bluuebunny/crossref_metadata_2025 huggingface dataset:
Capítulo 5: Alineación entre prácticas pedagógicas y estilos de aprendizaje en la enseñanza universitaria: un análisis en la Licenciatura de Mercadotecnia de la UACyA –UAN - México
Authors:   Universidad Autónoma de Nayarit, Valle Escobedo Rocío Mabeline , García Gómez Laura Esther ,   Universidad Autónoma de Nayarit, Castañeda Ibarra Raquel ,   Universidad Autónoma de Nayarit, Sifuentes Ocegueda Ana Teresa ,   Universidad Autónoma de Nayarit
Published: January 2025

El presente estudio analiza la importancia de promover programas de formación docente y recursos institucionales que permitan implementar metodologías inclusivas; por lo que se tiene el objetivo de investigar las prácticas pedagógicas utilizadas por los docentes y su alineación con los estilos de aprendizaje predominantes entre los estudiantes de la Licenciatura de Mercadotecnia. Se utilizó una metodología de enfoque mixto, ya que se realizó tanto búsqueda de información documental como información cuantitativa a través de un formulario de Google con 13 ítems a 13 docentes de la Licenciatura de Mercadotecnia de la Unidad Académica de Contaduría y Administración (UACyA) de la Universidad Autónoma de Nayarit (UAN). Los hallazgos sugieren que los docentes perciben la importancia de adaptar sus métodos a los diferentes estilos de aprendizaje y reconocen el impacto positivo en el rendimiento académico. El estudio concluye que existe una necesidad crítica de promover programas de formación docente y recursos institucionales que permitan implementar metodologías inclusivas, facilitando una enseñanza alineada con los diversos estilos de aprendizaje. Se destaca la importancia de una enseñanza integral que potencialice el aprendizaje efectivo y el éxito académico para todos los estudiantes.
Capítulo 6: Diagnóstico y propuesta de mejora para la optimización de los procesos de recepción de mercancías para reducir los niveles de insatisfacción de los clientes
Authors:   Fundación Universitaria Tecnológico Comfenalco, Molina Guerrero Camilo , García Alexander Gary ,   Universidad del Sinú, Buitrago Ibañez Daniel ,   Instituto Universitario de la Paz, Plata Delgado Ervin Alfonso ,   Fundación Universitaria Antonio de Arévalo
Published: January 2025

El proyecto de investigación se centra en la empresa ACERMETAL S.A. dedicada a la transformación y fabricación de piezas de acero para todo tipo de sectores industriales. Para la empresa ACERMETAL S.A. tener el control de su cadena de suministro es crucial, para ello la recepción y registro de materias primas para la fabricación de piezas es fundamental para el desarrollo de su proceso productivo. Sin embargo, es común encontrar inconsistencias en algunos de los procedimientos que afectan la eficiencia y el tiempo establecido en cada actividad. Por tal motivo, este proyecto busca realizar una propuesta de mejora en los puntos claves del proceso de recepción basado en herramientas tecnológicas que soportan su principal software de control empresarial que está enfocado únicamente a la gestión de almacenes e inventarios, con este soporte tecnológico se busca reducir el tiempo y recursos utilizados para cada actividad del proceso. Esta búsqueda de eficiencia cobra aún más relevancia en un entorno empresarial altamente competitivo, donde los márgenes de tiempo y costos son factores determinantes para el éxito, es importante señalar que la reducción del tiempo utilizado no debe comprometer la calidad de las materias primas ni la precisión de los registros. Por ello, las propuestas de mejora a presentar se basarán en el equilibrio entre eficiencia y calidad, buscando asegurar la excelencia en cada etapa del proceso de recepción.
Capítulo 7: Conciencia metapragmática y texto narrativo bilingüe (anécdota) en sujetos en formación bilingüe español-inglés de una universidad pública colombiana
Authors:   Universidad del Quindío, Silva García Yuri Marcela , Valencia Castrillón Martha Luz ,   Universidad del Quindío
Published: January 2025

El acercamiento a las nuevas dinámicas de la globalización, le ha configurado al ser humano desenvolverse como un ciudadano del Siglo XXI, caracterizado por el avance en competencias emergentes como el dominio de una lengua adicional a su lengua materna. En el contexto colombiano, los programas de formación enfrentan desafíos en cuanto al desarrollo adecuado del bilingüismo escolar y del abordaje de habilidades de producción como la escritura de diferentes tipologías textuales a nivel universitario. El presente estudio tiene como objetivo analizar la relación entre la conciencia metapragmática y el texto narrativo (anécdota) en sujetos en formación bilingüe (español-inglés) de una licenciatura en Lenguas Modernas de una universidad pública colombiana. Se planea implementar un enfoque cuantitativo con diseño no experimental y alcance correlacional. La muestra poblacional corresponde a 32 estudiantes de segundo semestre de dicho programa académico. Los instrumentos de recolección de datos son: test para caracterizar la conciencia metapragmática y corpus de escritura de un texto narrativo (anécdota) en español y otro en inglés. Para el análisis de los datos se hará uso de la triangulación hermenéutica. Se espera encontrar que, existe una relación significativa entre las habilidades metapragmáticas de los sujetos y su nivel de producción narrativa escrita bilingüe, la necesidad de desarrollar e implementar currículos con variedad de actividades que promuevan un mejor desempeño escrito por medio del desarrollo de las habilidades metapragmáticas, al igual que, la conciencia de los docentes en todos los niveles educativos, acerca del compromiso de fomentar la escritura bilingüe para promover procesos comunicativos de aprendizaje, comprensión y uso de las lenguas en contacto. El presente documento propone presentar un avance en el desarrollo de la investigación en relación al planteamiento del problema, los antecedentes, el marco teórico, metodológico y algunos resultados esperados.
Transgender: The Equal Human and Gender Identity
Authors: Faujdar Dr. Rishikesh Singh , Dhar Dr. Rumi
Published: January 2025

The right to live is given to every citizen by birth but not all are privileged to live by it. Our society is divided based on gender, sex, race etc. despite of several efforts made to make it one. Transgender is one most such section in the society which had been excluded from society from ancient times up to an extent that their existence is felt like no one else. Laws were made to give them equal human rights, to accept them equally as part of society. Legislations were passed by different countries but ironically it can never be enough to subside the years of neglection and disgrace, but they have implemented for the improvement of transgender. Prevention still exists in the hearts and mindset of people at a large level; they still question their dignity and identity. Collaborative efforts by state authorities, citizens and opening opportunities will lead to fresh path of no discrimination, gender equality, liberty, and expression. This paper aims to explore the notion of transgender individuals as equal participants in society, emphasizing.
Streamlining Democracy: Exploring Constitutional Adjustments for Synchronized National Elections
Authors: Jamtani Dr. Pankaj
Published: January 2025

The concept of “One Nation, One Election” (ONOE) has emerged as a significant electoral reform proposal in India, aiming to synchronize the schedules of elections to the Lok Sabha (Lower House of Parliament) and State Legislative Assemblies. This research undertakes a comprehensive legal inquiry into the constitutional amendments required to implement ONOE, evaluating its feasibility, implications, and potential challenges within the Indian constitutional framework. The research begins by examining the historical context and rationale behind the ONOE proposal, tracing its evolution and the diverse perspectives it has garnered among policymakers, legal experts, and political stakeholders. It analyzes the constitutional provisions governing the electoral process in India, particularly focusing on the distribution of legislative powers between the Union and the States, the tenure of elected bodies, and the process of dissolution and reconstitution of legislative assemblies. Central to the legal inquiry is an examination of the constitutional amendments necessary to facilitate ONOE. This entails a detailed scrutiny of Articles 83, 85, 172, and related provisions of the Constitution, which prescribe the duration and timing of parliamentary and state legislative assemblies’ terms. The paper evaluates the feasibility of amending these provisions to align the election schedules, considering the procedural requirements for constitutional amendments and the potential implications on federalism, electoral integrity, and political accountability. Furthermore, the research explores the interplay between ONOE and constitutional principles such as federalism, separation of powers, and the basic structure doctrine. It delves into the delicate balance between ensuring uniformity and preserving the autonomy of State governments in the electoral process, critically analyzing the legal and political ramifications of centralizing election schedules.
Development of a Digital Accounting Framework for Financial Reporting of Marine Conservation Projects
Authors: Renaldo Nicholas
Published: January 2025

This research aims to develop a digital accounting framework tailored for the financial reporting needs of marine conservation projects, emphasizing the integration of cutting-edge technologies to meet the demands of accountability, transparency, and efficiency in the sector. This study employs a qualitative research methodology to develop a digital accounting framework tailored for the financial reporting of marine conservation projects. The collected data will be analyzed using thematic analysis to identify patterns, themes, and insights related to the development of the digital accounting framework. By integrating stakeholder needs, institutional compliance, and advanced technological tools, the framework addresses key challenges such as transparency, regulatory adherence, and financial efficiency. The adoption of this framework can enhance accountability and operational effectiveness while supporting marine conservation goals.
Pregătiri politico-diplomatice pentru misiunea spaţială a primului cosmonaut român, Dumitru Prunariu, 1980-1981
Authors:   INSTITUTUL NAȚIONAL PENTRU STUDIUL TOTALITARISMULUI, Șandru Florin
Published: January 2025

Dumitru-Dorin Prunariu is the first and, so far, only Romanian astronaut. His mission was part of the “Intercosmos” program, which also included Soviet missions with astronauts from Bulgaria, Hungary, Vietnam, and Mongolia—countries from the former Soviet bloc. Later, under the same “Intercosmos” program, French, British, and Japanese astronauts also participated in space missions. This article presents the details of the preparations for the “Soyuz 40” mission, as described in the telegraphic communications between the Romanian Embassy in Moscow and the Romanian Ministry of Foreign Affairs, led by Ștefan Andrei.
Iuliu Maniu, de la Carol al II-lea la Ion Antonescu
(Din textele lui Corneliu Coposu: jurnal, confesiuni, conferințe)
Authors: Mâță Cezar
Published: January 2025

In his memoirs and other writings, Corneliu Coposu presents the actions and achievements of one of the key figures in interwar Romanian politics, particularly during the 1930s and the period of the Second World War, in which Romania was involved. This figure is Iuliu Maniu, the leader of the National Peasant Party. Since 1930, Corneliu Coposu had been a close associate of Maniu, supporting him in all political endeavors. Through his accounts and various written reports, Coposu reveals insights into private discussions he had with Maniu—some of which were little known at the time and remain so even today.
Additionally, Coposu sheds light on the impact of Maniu's relationships with the most important political figures of the era, including his opponents, King Carol II and General Ion Antonescu. These relationships, along with the hopes and disillusionments following the events of August 23, 1944, had a significant influence on Maniu’s political journey.
Revoluţia Română din Decembrie 1989 în documente diplomatice italiene, II
Authors:   Facultatea de Teologie Ortodoxă „Justinian Patriarhul”, Iancu Dorin Demostene , Jianu Octaviana ,   INSTITUTUL NAȚIONAL PENTRU STUDIUL TOTALITARISMULUI
Published: January 2025

The Romanian Revolution of December 1989, during and after this historical moment, is documented in the Archivio Storico della Presidenza della Repubblica, Ufficio Per Gli Affari Diplomatici. These documents concern several aspects: the authorities and events in Romania; interventions by the Italian authorities in Romania; telegrams congratulating President Francesco Cossiga for his stance on the bloody repression of demonstrators; telegrams and declarations of solidarity with the Romanian people, issued either by Italian politicians or by Romanian refugees in Italy; telegrams urging international adoption procedures, sent by Italian adoptive families and addressed to President Cossiga; and telegrams concerning international aid to Romania.
„A fi la înălțimea misiunii”. Ghizii interpreți: mediatori lingvistici, culturali și politici
Authors:   INSTITUTUL NAȚIONAL PENTRU STUDIUL TOTALITARISMULUI, Stratone Carmen
Published: January 2025

This is a review of the book Les complices d’une utopie en construction. Les guides-interprètes roumanins dans la première décennie communiste by Lucia Dragomir, Pro Universitaria Publishing House, București, 2023, 234 p
ACECLOFENAC AND DICLOFENAC: A REVIEW ON LIQUID CHROMATOGRAPHY TECHNIQUES
Authors: Harshith Kumar R  , Abhishek K  , Rakesh Kumar Jat
Published: January 2025

The literature entitles the various analytical techniques like, High Performance Liquid Chromatography, Liquid Chromatography-Mass spectrometry. In this literature we reviewed the various analytical, stability studies, impurity profiling and bio-analytical methods used for the estimation of selected drugs. This review gives the concise and collective information about the analytical validative parameters like Limit of detection (LOD), Limit of Quantification (LOQ), Standard Curve, Accuracy & Precision for the analysis of Aceclofenac and diclofenac alone or combination with other drugs. This review helps to carry out further analytical and Bioanalytical studies on the mentioned drugs.
FORMULATION AND OPTIMIZATION OF GASTRO-RETENTIVE FLOATING TABLETS OF ENALAPRIL MALEATE AND LOSARTAN FOR ENHANCED BIOAVAILABILITY AND THERAPEUTIC EFFICACY
Authors: Rohit Jaimini  , Dr. Manish Jaimini
Published: January 2025

The objective of this study was to formulate and optimize gastro-retentive floating tablets of Enalapril Maleate and Losartan to enhance their bioavailability and therapeutic efficacy. These drugs, commonly used in the management of hypertension and heart failure, suffer from limited solubility and rapid gastric emptying, which reduce their effectiveness. Gastro-retentive floating tablets were developed using hydroxypropyl methylcellulose (HPMC K4M) and guar gum as release-controlling agents, with sodium bicarbonate and citric acid as effervescent agents to ensure buoyancy. Twenty formulations were prepared using the direct compression method and evaluated for critical parameters, including hardness, friability, swelling index, floating lag time, total floating time, and in-vitro drug release.Preformulation studies confirmed the compatibility of the drugs with excipients, with no chemical interactions detected using FTIR spectroscopy. The micrometric properties of the powder blends demonstrated excellent flowability and compressibility, ensuring suitability for tablet manufacturing. All formulations showed acceptable weight variation, hardness, and friability. The floating lag time ranged from 4.3 to 5.1 minutes, and total floating times exceeded 8 hours for all batches. Drug content ranged from 96.79% to 99.57%, reflecting uniformity and accuracy in dosing.In-vitro dissolution studies revealed sustained release profiles, with optimized formulations achieving over 90% cumulative drug release within 12 hours. Batch F7 demonstrated the best overall performance, with a high swelling index, minimal floating lag time, prolonged floating duration, and consistent drug release. These findings indicate that gastro-retentive floating tablets of Enalapril Maleate and Losartan can effectively address challenges associated with poor bioavailability and rapid gastric emptying, offering a promising approach for improved therapeutic outcomes and patient compliance.
Análisis Comparativo de los Coeficientes Alfa de Cronbach, Omega de McDonald y Alfa Ordinal en la Validación de Cuestionarios
Authors: Colorado Romero Jesús Raúl , Romero Montoya Mauricio , Salazar Medina Marcos , Cabrera Zepeda Gabriela , Castillo Intriago Víctor Ricardo
Published: January 2025

Este artículo examina los coeficientes Alfa de Cronbach, Omega de McDonald y Alfa Ordinal como herramientas para evaluar la fiabilidad de cuestionarios en el contexto de una investigación. Se describe cada coeficiente, destacando sus fundamentos, ventajas y limitaciones. Además, se realiza una comparativa detallada considerando su adecuación a diferentes tipos de datos y escalas, especialmente en aplicaciones con escalas tipo Likert y datos ordinales. Los resultados muestran que cada coeficiente tiene su utilidad dependiendo del contexto, con el Alfa Ordinal sobresaliendo en datos ordinales, mientras que el Omega de McDonald destaca por su precisión al no requerir tau-equivalencia.
When Anticancer Agents Are Applied to Adenocarcinoma Cells, Platelets Improve Their Survival Rate Medications: Mechanisms and Chemoresistance Implications
Authors:   Apollo College of Pharmacy, Anjora Durg C.G 491001, India., Sonwani Hari Prasad
Published: January 2025

Overview and Goals: Cancer cells are more likely to survive when they are not constrained by feedback control mechanisms. Chemosis and persistent side effects from chemotherapy might make cancer treatment more difficult to manage tumor cells' ability to survive. In this study, we looked at how platelets affect the survival and death of cancer cells treated with chemotherapy AN EXPERIMENTAL METHOD: Human adenocarcinoma cells, namely colonic (Caco-2) and ovarian (59 M) cells, were cultured for 1, 24, or 72 hours with or without platelets (1.5 · 108 mL-1). The drugs used were 5-fluorouracil (1–300 mg·mL–1) or paclitaxel (1–200 mg·mL–1). After incubation, cancer cells were isolated and used flow cytometry, Western blotting, real-time PCR, TaqMan® Gene Expression Assays, and proteomics to determine if the cells had survived or died ESSENTIAL OUTCOMES: Human platelets multiplied the ability of colonic and ovarian adenocarcinoma cells treated with 5-fluorouracil and paclitaxel, two common anticancer medications, to survive. Cancer cells expressed more cyclins, DNA repair proteins, and MAPKs when platelets were present. They also down- and up-regulated pro- and anti-apoptotic genes, increased the number of cells synthesizing DNA, and decreased the number in the quiescent phase. The thrombospondin-1, TGF-b, clustering, and chemokine RANTES were released, according to an investigation of the platelet-Caco-2 secretum. Lastly, thrombospondin-1 and human recombinant RANTES increased the ability of Caco-2 cells exposed to paclitaxel to survive SUMMARY AND IMPLICATIONS These findings show that platelets boost the survival, growth, and chemoresistance of adenocarcinoma cells to conventional anticancer medications. Changing the connections between cancer cells and platelets may be a fresh approach to raising the effectiveness of chemotherapy.
Implementasi Pohon Literasi Pada Program Kampus Mengajar di SD 81 Bukamata
Authors: Ashar Ashar , Idamayanti Reski
Published: January 2025

Program Kampus Mengajar bertujuan untuk meningkatkan mutu pendidikan di sekolah-sekolah daerah dengan melalui keterlibatan mahasiswa dalam kegiatan pengabdian masyarakat. Pengabdian ini membahas implementasi Pohon Literasi sebagai inovasi dalam membangun budaya literasi di SD 81 Bukamata. Pengabdian bertujuan untuk meningkatkan minat baca siswa di SD 81 Bukamata melalui pendekatan kreatif dan inovatif, mengembangkan budaya literasi di lingkungan sekolah, memberikan pengalaman belajar yang menyenangkan dan bermakna bagi siswa, mendorong keterlibatan guru, orang tua, dan masyarakat dalam mendukung program literasi. Metode yang digunakan meliputi observasi awal, pembuatan media Pohon Literasi, pelaksanaan kegiatan membaca harian, dan evaluasi perkembangan siswa. Hasil menunjukkan peningkatan signifikan dalam partisipasi siswa terhadap kegiatan literasi, penguatan budaya membaca di sekolah, serta kolaborasi yang erat antara guru, siswa, dan orang tua. Program ini juga berhasil menciptakan suasana belajar yang interaktif dan menyenangkan. Dengan adanya Pohon Literasi, siswa tidak hanya terdorong untuk membaca tetapi juga untuk menulis dan berbicara dengan lebih percaya diri. Program ini diharapkan dapat menjadi model untuk diterapkan di sekolah lain guna membangun ekosistem literasi yang lebih luas dan berkelanjutan
"Grammar Talks: Pelatihan Peningkatan Pemahaman Tata Bahasa melalui Diskusi Interaktif"
Authors: Badruddin Dahniar , Suhrah Suhrah , Juspaningsih Juspaningsih
Published: January 2025

Kegiatan pengabdian ini Masyarakat ini bertujuan untuk meningkatkan pemahaman tata bahasa Inggris member New Generation Club (NGC) melalui metode interaktif. Program ini terdiri dari beberapa tahap, termasuk rapat perencanaan, pelatihan terpandu, diskusi kelompok, simulasi praktik, serta pemberian buku referensi yang relevan seperti buku “The Art of English” dan “Grammar is Easy”. Hasil pelatihan ini menunjukkan adanya peningkatan yang signifikan dalam kemampuan tata bahasa peserta, serta peningkatan kepercayaan diri mereka dalam berkomunikasi menggunakan bahasa Inggris. Metode diskusi interaktif yang diterapkan terbukti efektif dalam memperdalam pemahaman peserta terhadap struktur tata bahasa, sementara pemggunaan buku referensi memberikan landasan yang kuat untuk pembelajaran yang berkelanjutan. Para peserta menunjukkan kemajuan tidak hanya dalam aspek pemahaman tata bahasa, tetapi juga dalam kemampuan berbicara dan berinteraksi dalam bahasa Inggris. Pelatihan ini memberikan konstribusi yang positif terhadap pengembangan keterampilan berbahasa Inggris member New Generation Club, dan dengan pendekatan yang menyenangkan dan relevan terhadap kebutuhan para peserta, pelatihan ini mendorong peserta untuk terus belajar dan mengasah keterampilan bahasa mereka secara mandiri
The imperial character of modern superpowers and the new geopolitical formula of world order
Authors: Dergachev Vladimir
Published: January 2025

The Great Hour of geopolitics has arrived, when in the process of geopolitical transformation a new formula of world order is born: “Whoever has the largest volume of digital information and the speed of its processing, owns the world.” At this Hour, it is time to think about the image of the near future and to do this, remember the imperial past. In the revolutionary era of IT technologies, robotization of all types of activity, time is accelerating and, along with geographical space, cyberspace is being intensively developed. New outposts for the development of the Earth's multidimensional space will be formed cyberports with quasi-state functions similar to the East India Companies of the past. The struggle between the neoliberal model of the West and the global majority for traditional values will intensify.
International legal regulation of integration of migrants children into the educational environment. Overview of national practices
Authors: Reshetnikova Viktoriia
Published: January 2025

As a result of the present migration situation, an increasing number of foreign-born youngsters struggle to integrate into the host nation's educational system. Although the universal international legal level has established the fundamentals of foreign residents' legal status, including their right to education, the process of integrating into the educational system is still outside its purview complicating the regulation of the process. Language problems and educational institutions' reluctance to modify the curriculum to accommodate this group of children's demands are additional challenges that are emphasized. The worldwide legal framework for integrating migrants’ children into the educational system is analyzed in this study, along with state policies that assist educational institutions and children.
Digital diplomacy for peace: a new frontier in international relations
Authors: Lisenco Vladlena
Published: January 2025

The rise of digital technologies has changed how countries interact, offering new ways to promote peace and solve global conflicts. Digital diplomacy is a modern approach that uses information and communication technologies to improve dialogue, cooperation, and understanding between nations, organizations, and citizens. This article looks at how digital tools and platforms support peacebuilding, especially by connecting different groups, fighting misinformation, and resolving conflicts. Digital diplomacy allows governments and non-governmental actors to communicate in real time, giving marginalized communities a voice and encouraging inclusive participation in peace efforts. By increasing transparency and accountability, it modernizes traditional diplomacy and provides tools to address conflicts early. Digital platforms also play an important role in encouraging cultural exchange and aiding humanitarian initiatives in conflict zones. Despite its potential, digital diplomacy faces serious challenges. Cybersecurity risks, unequal access to digital resources, and the misuse of technology to spread disinformation threaten its success. This paper highlights the need for global agreements, ethical guidelines, and programs to strengthen digital capacity to minimize these risks and ensure that digital diplomacy supports peace rather than creating new tensions. Using real-world examples and theoretical perspectives, this research explains how digital transformation is changing diplomacy in the 21st century. It argues that integrating technology into diplomatic practices is crucial for building long-lasting peace and ensuring global stability. This approach opens new opportunities for innovation and cooperation in international relations.
Sorption-based Spectrophotometric Assay for Lead(II) with Immobilized Azo Ligand
Authors: Ashirov Mansur Allanazarovich , Yusupova Mavluda Rajabboyevna , Takhirov Yuldash Rajabovich , Smanova Zulaykho Asanaliyevna , Avazyazov Mukhammad Akbarovich
Published: January 2025

This study introduces a novel sorption-spectrophotometric method for the determination of lead(II) ions in water, addressing the critical need for sensitive and selective environmental monitoring. The method utilizes Amido Black (AB), a diazo dye, immobilized on a hexamethylenediamine-modified polyacrylonitrile fibrous support (PPD-1). The resulting immobilized reagent system (Pb(II)-AB/PPD-1) exhibits a significant bathochromic shift upon complexation with Pb(II), enabling spectrophotometric determination at 490 nm.
Optimal conditions for immobilization and complexation were established, including a pH range of 6-7 and an AB concentration of 8.2·10⁻⁵ M on the support. The method demonstrates a linear response to Pb(II) concentrations between 5 - 50 µg/ml (R² = 0.9938), with a low limit of detection (0.141) and quantification (0.47). Interference from common metal ions was minimal or mitigated with citric acid. Application to natural water samples showed excellent accuracy and precision (RSD ≤ 2.9).
The immobilized system offers a simplified procedure by eliminating elution steps, enhancing throughput, and achieving a ten-fold improvement in the limit of detection compared to solution-based methods. This rapid, sensitive, and selective method presents a promising alternative for lead(II) determination, offering comparable or superior performance with added benefits of simplicity and enhanced sensitivity.
Lavado con HCG previo a transferencia embrionaria en una clínica de reproducción humana asistida, ubicada sobre 2800 msnm, en Ecuador
Authors: Sanchez-Apaza Carmen Maribel , Vargas-Carrera Dayana Monserrath , Durán Chavéz José Augusto
Published: January 2025

This study analyzed the effect of intrauterine hCG washout prior to embryo transfer in 17 patients in an assisted reproduction clinic in Latacunga, Ecuador, located at 2800 masl. A dose of 500 IU of hCG administered 15 minutes before transfer was used. The primary outcomes evaluated were the clinical pregnancy rate (positive quantitative B-hCG and positive embryonic heartbeat), obtaining a rate of 18%. Among the secondary outcomes, it was noted that most patients used their own eggs and sperm (41%), and a single embryo was transferred in 53% of the cases. The main cause of infertility was idiopathic (41%). Although the use of intrauterine hCG showed potential benefits in previous studies for cases with recurrent implantation failure, no significant improvement in reproductive outcomes was evident in this context. This highlights the complexity of the molecular and cellular processes involved in embryo implantation. It is suggested that the technique may be useful in specific cases of previous implantation failure, but further studies are required to evaluate its effectiveness under heterogeneous conditions.
Os Limites Materiais da Justiça Penal Negociada, à Luz dos Direitos Fundamentais e Humanos
Authors: Seródio Rogério Luiz
Published: January 2025

Um dos ramos do direito penal e processual penal brasileiro que ainda se encontra em formação é a justiça penal negociada, tema de grande relevância no campo do direito penal, despertando debates acalorados e levantando questões éticas e jurídicas. O presente trabalho tem como objetivo analisar os institutos da justiça penal negociada, seus limites éticos e jurídicos, além de fazer uma comparação entre a justiça negociada nos Estados Unidos da América e no Brasil.

A justiça penal negociada, também conhecida como plea bargaining, é um mecanismo que permite a resolução de casos criminais por meio de acordos entre a acusação e a defesa, com o objetivo de evitar um julgamento formal. Esse processo envolve a negociação de uma pena reduzida em troca de uma confissão ou declaração de culpa por parte do acusado.

Palavras-Chave: acordo de não persecução penal, delação premiada, justiça negociada, plea bargaining.
TUTORIAL MENGGUNAKAN MEDIA FACEBOOK : MENYUSUN LAPORAN KEUANGAN SEDERHANA UNTUK USAHA MIKRO KECIL
Authors: Kasman Kasman , Wahyudi Dedy , Hamdanur Peris , Yusuf Andi Muhammad
Published: January 2025

Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan kemampuan para peserta pelatihan untuk dapat menyususun Laporan Keuangan Sederhana untuk usaha kecil. Metode pelaksanaan adalah dengan menggunakan media Facebook yang jangkauannya lebih luas untuk mengadakan tutorial.Peserta sangat antusias dengan tutorial melalui media facebook ini dibuktikan dengan jumlah peserta untuk satu seri tutorial ada yang sampai 10 kali lipat dari target. Dengan tutorial  ini  peserta dapat berulang-ulang menonton video tutorial sehingga mereka dapat menyusun laporan keuangan sederhana untuk usaha kecil yang mereka miliki. Masih diperluksan kegiatan pendampingan agar laporan keuangan sederhana yang disusun oleh para peserta dapat sesuai dengan standar akuntansi yang berlaku sehingga peserta yang usahanya semakin berkembang dapat memperoleh kredit modal kerja dari perbankan.
Methodological Accountability in Systematic Case Law Analysis: Insights from an Empirical Analysis in the Netherlands
Authors: Verbruggen Paul , Wijntjens Lianne
Published: January 2025

As systematic case law analysis becomes more extensive and intricate as an approach to doing legal research, the need to justify the methods and techniques used for data collection, selection, and analysis grows correspondingly. Without such methodological accountability, the reliability and replicability of this type of legal (empirical) research are compromised, undermining their contribution to legal scholarship and practice. This article investigates the methodological accountability in systematic case law analysis. We conducted an empirical study to evaluate how researchers in the Netherlands account for their processes of collecting, selecting, and analyzing legal decisions and opinions of dispute resolution bodies. Our meta-analysis of systematic case law analysis encompasses 105 academic studies that utilize systematic case law analysis, providing an overview of the current state-of-the-art in the Netherlands. Based on the findings of our case study, we offer best practice guidelines for ensuring methodological accountability in systematic case law analysis.
Green microextraction techniques in therapeutic drug monitoring
Authors: Kousi Maria , Samanidou Victoria
Published: January 2025

Therapeutic drug monitoring (TDM) is crucial for optimizing drug therapy, particularly for medications with narrow therapeutic windows. By measuring drug concentrations in biological fluids, TDM aids in dose individualization, adherence assessment, and the prevention of adverse effects. Recent advancements focus on miniaturized and eco-friendly sample preparation techniques, such as microextraction methods, which are efficient and low-cost. These include liquid- and solid-phase microextraction, offering benefits such as automation and high-throughput performance which have significantly improved TDM efficiency. Additionally, the emergence of microsampling offers a less invasive alternative to traditional blood collection for TDM and pharmacokinetic studies. Coupling these innovations with sensitive analytical techniques, like liquid chromatography-tandem mass spectrometry, enables accurate and reliable drug quantification from minimal sample volumes. These developments collectively enhance the clinical utility of TDM and contribute to improved patient outcomes. This paper provides a comprehensive review of recent advancements in green microextraction techniques as applied to therapeutic drug monitoring.
Comparing the Effectiveness of Expansionary Monetary vs. Fiscal Policies in Boosting GDP in Cambodia
Authors: Mong Mara
Published: January 2025

Four indicators were incorporated into a system of equations using a structural vector autoregressive (SVAR) model, specifically gross domestic product (GDP), consumer price index (CPI), money supply (M2), and government expenditure (G), to assess the effectiveness of macroeconomic policies, including both monetary and fiscal policies, in Cambodia. The empirical results indicated that the growth of the money supply produced a positive impact on economic growth, peaking in the second quarter before gradually converging to equilibrium by the fourth quarter. Conversely, government expenditure and the inflation rate initially exerted a negative impact on economic growth during the first and second quarters, followed by a positive effect starting in the second quarter, ultimately converging to equilibrium by the fourth quarter.
Unlocking Potential: Addressing Societal and Economic Barriers for Qatari Youth in the Tourism and Hospitality Sector
Authors: Al-Mohannadi Noora
Published: January 2025

This quantitative research examines the factors discouraging Qatari youth from pursuing careers in the tourism and hospitality sector. It explores socio-cultural and industry-specific barriers, evaluates the effectiveness of government and private initiatives supporting local employment in the field, and proposes strategies to enhance the sector's appeal to Qatari youth. The findings reveal that societal attitudes play a significant role in shaping career choices, with 31% of respondents perceived a lack of community acceptance and 30.3% expressing uncertainty about societal openness to such roles. Many participants also have associated hospitality jobs with a negative impact on self-esteem. Additionally, 17% cited religious concerns, believing that Islam does not endorse such professions. Beyond societal influences, financial and occupational factors contribute to the reluctance of Qatari youth to enter the hospitality industry. Low financial incentives and demanding working conditions—such as long hours and high-pressure environments—were key deterrents. Compared to lucrative sectors like oil, gas, and banking, hospitality careers offer fewer financial benefits and limited opportunities for professional advancement, making alternative industries more attractive to Qatari job seekers.
An Analysis of the Regulation and Use of Data Protection Measures in the Context of the Fourth Industrial Revolution in South Africa
Authors:   Research Director, Research Professor and Professor of Securities and Financial Markets Law, Faculty of Law, North-West University, South Africa, Chitimira Howard , Motlogeloa Keamogetse ,   Lecturer, Faculty of Law, University of Cape Town, South Africa
Published: January 2025

The proliferation of new technologies during the fourth industrial revolution (4IR) has given rise to the misuse of data and the commission of cybercrimes in many countries, including South Africa. Accordingly, measures that are aimed at regulating and/or safeguarding data should be carefully employed to protect individuals from the misuse of data by unscrupulous persons. This article discusses the basic tenets of data governance and data regulation during the fourth industrial revolution under the relevant South African data laws. Furthermore, the risks associated with the use of data in various organisations and the information and communication technology (ICT) sector are examined. This is done to highlight the need for robust data governance through adequate data laws that provide sufficient regulatory measures and guidelines to curb the misuse and unlawful use of data in South Africa. The provision and regulation of data governance measures under the Electronic Communications and Transactions Act 25 of 2002, the Promotion of Access to Information Act 2 of 2000, the Consumer Protection Act 68 of 2008, the Protection of Personal Information Act 4 of 2013 and the Cybercrime Act 19 of 2020 are analysed to determine their adequacy.
From Bureaucracy to Innovation: How Civil Servants Can Modernize Administration
Authors:   - Faculty of Legal Sciences, Hyperion University, Bucharest, Romania, Dumitrescu Cristian
Published: January 2025

Civil servants can play an important role in identifying the needs and challenges facing public administration and citizens. Through feedback and interaction with citizens and other stakeholders, they can identify existing problems and offer innovative solutions. This study provides a comprehensive framework for understanding and applying innovation in public administration, focusing on the transformation of bureaucracy into a flexible and citizen-centered system. The objectives of the study are: identifying the principles of innovation in public administration, studying the role
of civil servants in the modernization process, analyzing the obstacles in the transformation process, assessing the impact of technology and digitalization on the efficiency of the administration. Research will begin with a literature review and an analysis of academic articles and government reports on innovation in public administration. This will include previous studies, successful models of administrative reform and theoretical frameworks on bureaucratic transformation. The results and implications of the study lead to: identifying effective strategies for modernizing the administration, increasing awareness of the role of public servants as agents of change, and highlighting the role of technology in reducing bureaucracy. By promoting innovation strategies, public administration will be able to respond more quickly and effectively to the needs of citizens, reducing bureaucracy and improving the quality of public services.
Gamification and Social Media: Transforming English Grammar Learning in EFL Classrooms
Authors: Noori Abdullah
Published: January 2025

This study investigated the impact of gamification and social media on enhancing English grammar learning in EFL classrooms. A quasi-experimental research design was employed, involving 65 male students from a private higher education institution. Participants were divided into experimental and control groups. The experimental group engaged in gamified activities and utilized social media platforms, while the control group followed traditional learning methods. After the experiment, a survey questionnaire was administered to the experimental group to gather their perceptions of the interventions. Pre- and post-test scores were analyzed using descriptive and inferential statistics. The results demonstrated that gamification and social media significantly improved student engagement and grammar retention. A statistically significant improvement was observed in the grammar scores of the experimental group compared to the control group. Gamified activities, such as points, leaderboards, and rewards, enhanced motivation and created a more interactive learning environment. Similarly, social media platforms, particularly WhatsApp and Facebook groups, facilitated peer feedback, collaborative learning, and the practical application of grammar rules in authentic contexts. Participants in the experimental group reported greater confidence in using grammar structures correctly, with many highlighting reduced language learning anxiety and increased motivation due to gamification and social media use. This study contributes to the growing body of literature on technology-enhanced language learning, providing practical implications for EFL educators seeking to integrate these tools to improve language proficiency.
Una mirada al interior animal a través de la osteología
Authors: Pastor Vázquez Juan Francisco , de Paz Fernández Félix Jesús , Barbosa Cachorro Mercedes
Published: January 2025

Además de las representaciones artísticas conservadas en pintura, escultura u otras formas, los yacimientos arqueológicos conservan las únicas partes del cuerpo animal que perduran a través del tiempo: los huesos.
Manifestações populares figurativas na cerâmica tradicional do entre Douro e Minho
Authors: Milhazes Maria Cláudia
Published: January 2025

En un principio, el trabajo de los alfareros se dedicó a la producción de vajilla y distintas piezas utilitarias o decorativas, pero, de forma simultánea y en la zona comprendida entre los ríos Miño y Duero, se desarrolló otro tipo de trabajo en arcilla, conocido como "figurado". "Figurado" es el producto del trabajo de alfareros artesanos que modelaban piezas que, en esencia, representaban la realidad o el imaginario de su vida cotidiana.
A Rákóczi-szabadságharc kezdetének eseményei az angol sajtóban
Authors: Hegedüs Gergő
Published: January 2025

The present study is intended to examine the early English reports of the Rákóczi’s War of Independence by evaluating the witnesses of The Daily Courant, The London Gazette and the edition of Daniel Defoe’s A Weekly Review of the Affairs of France, particularly the issues published between 1703 and 1704. Exceptional attention shall be paid to the specificities of early eighteenth century English press culture as well as to the functioning of the information network of the various newspapers and the active role played by the English ambassadors in Vienna. The analysis of the veracity of the information contained in such journals and the study of the various names given to Rákóczi’s followers shall be of special importance, which could also reflect firm political positions. The Daily Courant and The London Gazette sought to report on the rapid growth of the number of insurgents and their quick expansion as well as the accession of those with considerable combat experience. They also reported on the reasons they believed to be behind the outbreak of the freedom struggle and whether or not such intentions were justified.
A Holle anyó meseelemzése Jung archetípusai mentén
Authors: Pálffy Patrik
Published: January 2025

Ebben a rövid értekezésben a Holle anyó klasszikus meséjének elemzése kerül bemutatásra Carl Gustav Jung archetípusai mentén. Megvizsgáltam, milyen normatív élethelyzeti krízist mutat be a mese, és melyek azok a főbb, kollektív tudattalanra utaló archetípusok, amelyek megjelennek a műben.
BLOQUEIO SUPRACLAVICULAR DO PLEXO BRAQUIAL GUIADO POR ULTRASSOM: CONTROVÉRSIAS E PERSPECTIVAS FUTURAS
Authors: Bruno Bernardo Nascentes , Castro Pedro Henrique Machado de , Weber Andressa de Azambuja Pias
Published: January 2025

O uso do Ultrassom permitiu o renascimento da técnica de Bloqueio do Plexo Braquial por via Supraclavicular (US-BSC) ao reduzir radicalmente o risco de complicações como pneumotórax e hematoma. Entretanto, nota-se grande variabilidade técnica na realização do US-BSC, o que dificulta uma padronização dessa importante ferramenta. A presente revisão narrativa da literatura ilustra as principais variações e controvérsias do US-BSC ao longo dos últimos 30 anos, sugerindo que futuros projetos de pesquisa busquem confirmar as seguintes hipóteses: o volume de 20 mL apresenta sucesso técnico (ST) similar a bloqueios com 30 mL, com possível menor incidência de paralisia diafragmática. Concentrações menores de ropivacaína (0,375%) podem ter ST e duração do bloqueio sensitivo (DBS) similar a concentrações maiores como 0,75% ou 0,5%. A injeção dupla ou múltipla pode contribuir para aumentar o ST em 30 minutos ou diminuir o tempo de latência (TL) quando comparadas com a injeção única. Bloqueios realizados para cotovelo e braço podem ter resultados inferiores aos observados em antebraço e mão. Por fim, bloqueios em populações pediátricas apresentam alto sucesso técnico, porém estudos randomizados e controlados são necessários para melhor definir doses ideais de AL nesta população.
DESAFIOS DA ASSISTÊNCIA FARMACÊUTICA NO SISTEMA ÚNICO DE SAÚDE (SUS) SOB O OLHAR DA ATENÇÃO PRIMÁRIA À SAÚDE
Authors: Silva Francisco Andesson Bezerra da , Araújo Diego Igor Alves Fernandes de , Lins Francisca Sabrina Vieira , Galvão José Guilherme Ferreira Marques
Published: January 2025

Pharmaceutical assistance within the Unified Health System (SUS) plays a central role in ensuring access to essential medicines and the effectiveness of public health actions, particularly in Primary Health Care (PHC), which serves as the main gateway to the system. This study aimed to investigate the challenges faced by pharmaceutical assistance in the SUS, with a focus on PHC, analyzing issues such as failures in distribution logistics, insufficient technical training of professionals, and poor integration between levels of care and information systems. Additionally, it addressed problems related to low patient adherence to treatment and the irrational use of medicines, factors that undermine the effectiveness of comprehensive care. The research was based on an in-depth literature review and employed qualitative methods to explore the complexity of pharmaceutical assistance management and the obstacles encountered in daily practice. Based on the identification of these challenges, recommendations were proposed for the formulation of more effective public policies, improvements in medication management, and enhanced training for health professionals. The study also highlights strategies to promote the rational use of medicines and optimize the quality of pharmaceutical care in PHC. It is expected that the findings will contribute to the improvement of pharmaceutical assistance within the SUS, ultimately strengthening the healthcare system as a whole.