bluuebunny/crossref_metadata_2025 huggingface dataset:
Physicochemical Characterization and Evaluation of the Binding Effect of Acacia etbaica Schweinf Gum in Granule and Tablet Formulations
Authors: Desta Kidan Haily , Tadese Ebisa , Molla Fantahun
Published: October 2021

This study is aimed at evaluating the binding effect of Acacia etbaica gum in granule and tablet formulations using paracetamol as a model drug. Some physicochemical properties of the purified gum such as pH, the presence of tannin and dextrin, solubility, viscosity, loss on drying, total ash value, water solubility index, swelling power, moisture sorption, and powder flow properties were investigated. Paracetamol granules were prepared using wet granulation method at 2%, 4%, 6%, and 8% w/w of the Acacia etbaica gum and compared with granules prepared with reference binders (PVP K‐30 and Acacia BP) in similar concentrations. The granules were characterized for bulk and tapped densities, compressibility index and Hausner ratio, angle of repose, flow rate, and friability. Finally, the prepared granules were compressed into tablets and evaluated for different tablet characteristics: weight uniformity, thickness, diameter, crushing strength, tensile strength, friability, disintegration time, and in vitro release profile. The physicochemical characterization revealed that tannins and dextrin are absent in the gum, and the gum has acidic pH. Both the moisture content and total ash values were within the official limits. Furthermore, the gum was found to be soluble in cold and hot water but insoluble in organic solvent and exhibited a shear thickening viscosity profile and excellent flow properties with excellent compressibility. The granules prepared with the gum of Acacia etbaica and reference binders showed good particle size distribution and excellent flow and compressibility properties. All the prepared tablets passed pharmacopeial specifications with respect to their uniformity of weight, thickness, and disintegration time. Tablets formulated with Acacia etbaica gum and acacia BP meet the compendial specification for friability at binder concentrations more than 2%. Drug release properties of all the batches formulated with Acacia etbaica, PVP, and acacia BP complied with the pharmacopeial specification. It can be concluded that the gum of Acacia etbaica could be explored as an alternative excipient for its binder effect in granule and tablet formulations.
Data Mining Method of Enterprise Human Resource Management Based on Simulated Annealing Algorithm
Authors: Xu Mingwei , Li Chuang
Published: October 2021

The human resources department of an enterprise relies on the “mining” of big data when carrying out human resource management and proposes a data mining method for enterprise human resource management based on the simulated annealing algorithm. Applying the simulated annealing algorithm, using the Metropolis algorithm to generate the sequence of solutions to the combinatorial optimization problem, finding the overall optimal solution of the combinatorial optimization problem, using big data directional mining and analysis to help companies establish and find a “radar” system suitable for talents, the maximum tree method is adopted; that is, a special graph is constructed to realize the effective application of data mining technology in enterprise human resource management. The optimization of nurse scheduling in a hospital was used for case analysis. The results show that the target value of the nurse scheduling model is 43.43% lower than the actual manual scheduling target value, the salary cost is reduced by 10.8%, and the nurse’s satisfaction with the shift is increased by 35.24%. After several iterations based on the simulated annealing algorithm, the optimal value of the solution of the simulated annealing algorithm remains unchanged at the 60th generation. Then, the search process is stopped when the 100th generation is reached, and the solution at this time is the optimal optimization value found by the algorithm.
A Novel Cancer Stemness-Related Signature for Predicting Prognosis in Patients with Colon Adenocarcinoma
Authors: Wang Wei , Xu Congrong , Ren Yan , Wang Shiwei , Liao Chunli , Fu Xiaoyan , Hu Haixia
Published: October 2021

Objective. To explore the cancer stemness features and develop a novel cancer stemness-related prognostic signature for colon adenocarcinoma (COAD). Methods. We downloaded the mRNA expression data and clinical data of COAD from TCGA database and GEO database. Stemness index, mRNAsi, was utilized to investigate cancer stemness features. Weighted gene coexpression network analysis (WGCNA) was used to identify cancer stemness-related genes. Univariate and multivariate Cox regression analyses were applied to construct a prognostic risk cancer stemness-related signature. We then performed internal and external validation. The relationship between cancer stemness and COAD immune microenvironment was investigated. Results. COAD patients with higher mRNAsi score or EREG-mRNAsi score have significant longer overall survival (OS). We identified 483 differently expressed genes (DEGs) between the high and low mRNAsi score groups. We developed a cancer stemness-related signature using fifteen genes (including RAB31, COL6A3, COL5A2, CCDC80, ADAM12, VGLL3, ECM2, POSTN, DPYSL3, PCDH7, CRISPLD2, COLEC12, NRP2, ISLR, and CCDC8) for prognosis prediction of COAD. Low-risk score was associated with significantly preferable OS in comparison with high-risk score, and the area under the ROC curve (AUC) for OS prediction was 0.705. The prognostic signature was an independent predictor for OS of COAD. Macrophages, mast cells, and T helper cells were the vital infiltration immune cells, and APC costimulation and type II IFN response were the vital immune pathways in COAD. Conclusions. We developed and validated a novel cancer stemness-related prognostic signature for COAD, which would contribute to understanding of molecular mechanism in COAD.
Impact of Permissive Hypoxia and Hyperoxia Avoidance on Clinical Outcomes in Septic Patients Receiving Mechanical Ventilation: A Retrospective Single‐Center Study
Authors: Nishimoto Kota , Umegaki Takeshi , Ohira Sayaka , Soeda Takehiro , Anada Natsuki , Uba Takeo , Shoji Tomohiro , Kusunoki Munenori , Nakajima Yasufumi , Kamibayashi Takahiko
Published: October 2021

Background. Septic patients often require mechanical ventilation due to respiratory dysfunction, and effective ventilatory strategies can improve survival. The effects of the combination of permissive hypoxia and hyperoxia avoidance for managing mechanically ventilated patients are unknown. This study examines these effects on outcomes in mechanically ventilated septic patients. Methods. In a retrospective before‐and‐after study, we examined adult septic patients (aged ≥18 years) requiring mechanical ventilation at a university hospital. On April 1, 2017, our mechanical ventilation policy changed from a conventional oxygenation target (SpO2: ≥96%) to more conservative targets with permissive hypoxia (SpO2: 88‐92% or PaO2: 60 mmHg) and hyperoxia avoidance (reduced oxygenation for PaO2 > 110 mmHg). Patients were divided into a prechange group (April 2015 to March 2017; n = 83) and a postchange group (April 2017 to March 2019; n = 130). Data were extracted from clinical records and insurance claims. Using a multiple logistic regression model, we examined the association of the postchange group (permissive hypoxia and hyperoxia avoidance) with intensive care unit (ICU) mortality after adjusting for variables such as Sequential Organ Failure Assessment (SOFA) score and PaO2/FiO2 ratios. Results. The postchange group did not have significantly lower adjusted ICU mortality (0.67, 0.33‐1.43; P = 0.31) relative to the prechange group. However, there were significant intergroup differences in mechanical ventilation duration (prechange: 11.0 days, postchange: 7.0 days; P = 0.01) and ICU stay (prechange: 11.0 days, postchange: 9.0 days; P = 0.02). Conclusions. Permissive hypoxia and hyperoxia avoidance had no significant association with reduced ICU mortality in mechanically ventilated septic patients. However, this approach was significantly associated with shorter mechanical ventilation duration and ICU stay, which can improve patient turnover and ventilator access.
Edaravone Combined with Clopidogrel Is Beneficial to Improve Efficacy, Neurological Impairment, and Life Function in Acute Cerebral Infarction Patients
Authors: Wu Liao , Sun Ying , Ni Guihua , Sun Bo , Ni Xiaoyu , Cai Shikun
Published: October 2021

Objective. This research aimed at investigating the efficacy of edaravone combined with clopidogrel on acute cerebral infarction (ACI) and its influence on the neurological deficit and life function. Methods. Totally, 154 ACI cases were included and then divided into the control group (CG) (n = 71) and research group (RG) (n = 83) according to the treatment methods. Patients in the CG were treated with clopidogrel alone, and those in the RG were under edaravone-clopidogrel combination therapy. The efficacy, adverse reactions, NIHSS score, cerebral hemodynamic indexes, and Fugl-Meyer scale (FMA) and Barthel index (BI) of activities of daily living (ADL) scores were observed. Results. Compared with before treatment, the symptoms of both groups were improved after treatment: the NIHSS scores decreased, FMA and ADL scores increased, and cerebral hemodynamic indexes were improved. Compared with the CG, the efficacy and cerebral hemodynamic indexes of the RG were better, the adverse reactions were equivalent, the NIHSS score was lower, and the ADL and FMA scores were higher. Conclusion. Edaravone combined with clopidogrel can effectively treat ACI and improve the neurological deficit and life function of patients.
Joint Inspection of HD Video and Robot in Substation Based on OCR Technology
Authors: Liao Xiao , Xie Ke , Qiu Zhen
Published: October 2021

The research on the joint inspection technology of HD video and robot in substation is of great significance in the operation and maintenance management of substation. The related research on multidimensional collaborative inspection technology of substation has attracted great attention. The substation monitoring system is designed to realize multidimensional collaborative inspection of HD video and inspection robot. OCR technology is used to improve the abnormal recognition system of inspection robot equipment. According to the collection of video information, DSP comprehensive information processing is carried out, and the detection information is analyzed by frequency domain filtering method through human-computer interaction interface. Meanwhile, the main component features of substation detection components are extracted by pattern recognition method, and the resolution model of similar features of video monitoring images is constructed. It plays an important role in the daily operation and maintenance of substation to construct the reliability visual tracking and identification model and optimize the multidimensional cooperative inspection system model.
Prediction of Regional Logistics Heat and Coupling Development between Regional Logistics and Economic Systems
Authors: Yin Guojun , Peng Jianhui
Published: October 2021

The research on logistics heat facilitates the understanding of the drivers of regional logistics development. However, many scholars ignore the difference between prediction methods in terms of attributes and focal points of data analysis during the selection of regional logistics heat prediction model. Regional logistics interacts with regional economy. However, the studies on the coupling development between the two systems fail to make a detailed analysis in the light of their actual situation. Therefore, the evaluation of the coordination degree is often biased. To solve the problem, this paper probes into the prediction of regional logistics heat and the coupling development between regional logistics and economic systems. Firstly, an index system was established to measure the level of coupling development between the two systems, and a grey relational analysis was performed on the indices, leading to the evaluation results on coordination degree. Next, a composite model of GM (1, 1) and backpropagation (BP) neural network was proposed, and the deviation interval of the composite predictions was predicted based on Markov chain prediction model. The proposed algorithm proved effective through experiments.
Safety or Efficiency? An ECSO Framework of Traffic Organization Optimization for LNG Carriers Entering and Leaving Port
Authors: Zhang Fan , Yu Hang , Li Haoran , Peng Liqun , Zhou Tuqiang
Published: October 2021

Liquefied Natural Gas (LNG) is a clean, efficient, and economic energy, which is mainly transported by LNG carriers in the marine industry. Massive storage of LNG has led to public concern about the possible hazards of LNG carriers for people and facilities. This paper aims to determine the appropriate level of a safety zone and to develop an optimized traffic organization scheme. An innovative ECSO framework is proposed to deal with these two tasks. The results of the comparative analysis show that the influence degree of the optimized scheme is 21%, which is distinctly lower than the previous scheme (33%). To some content, the proposed framework can provide meaningful enlightenments for stakeholders to improve port service level and ensure the safe operation of LNG carriers.
Performance Analysis of RIS-Assisted Mixed Dual-Hop FSO-RF Communication Systems over Exponentiated Weibull Channels
Authors: Liu Xinzhong , Zou Jian , Xie Wenwu , Peng Xin , Li Chunlai
Published: October 2021

Information security is the basis of economic development, information construction, and the protection of people’s and national interest. In this paper, the performance of reconfigurable intelligent surface (RIS)-assisted mixed dual-hop free-space optical-radio frequency (FSO-RF) communication systems is studied and analyzed to ensure the safe transmission of information. In this scheme, it is assumed that the atmospheric turbulence in the fading of the FSO channel follows the exponentiated Weibull distribution model and the fading of the RF channel follows the Rayleigh distribution model. Based on the mathematical function, the probability density function and cumulative distribution function of RIS-assisted mixed dual-hop FSO-RF communication systems are derived. Then, the expression of outage probability and the bit error rate of the system are derived from the channel statistics. Finally, the analysis results are verified by Monte Carlo simulation, and the effects of different parameters on the system performance are analyzed. The simulation results show that the atmospheric turbulence parameters, channel distance of FSO, intensity of atmospheric turbulence, and number of reflectors all affect the system performance.
Investigating the Effects of Dapagliflozin on Cardiac Function, Inflammatory Response, and Cardiovascular Outcome in Patients with STEMI Complicated with T2DM after PCI
Authors: Xue LiMing , Yuan Xian , Zhang Shuguang , Zhao Xia
Published: October 2021

Objective. To explore the effect of dapagliflozin on cardiac function, inflammation, and cardiovascular outcome in patients with ST-segment elevation myocardial infarction (STEMI) combined with type 2 diabetes (T2DM) after percutaneous coronary intervention (PCI). Methods. 70 patients with STEMI and T2DM were divided into the control group (n = 35) and the observation group (n = 35). Before surgery, patients in both groups were given conventional treatments such as coronary expansion, antiplatelet, anticoagulation, and thrombolysis, and PCI was performed. After the operation, both groups were given conventional antiplatelet, anticoagulation, lipid-lowering, and hypoglycemic treatments. On this basis, the observation group was treated with dapagliflozin tablets for 24 weeks. We observe and compare the left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (LVEF), myocardial enzyme spectrum, inflammatory reaction, and occurrence of adverse cardiovascular events (MACE) of the two groups of patients before and after treatment. Results. After treatment, the LVEDD and LVESD of the two groups were lower than those before treatment, and the observation group was lower than the control group (P < 0.05). The LVEF of both groups was higher than that before treatment, and the observation group was higher than the control group (P < 0.05). After treatment, the levels of two groups’ patients’ creatine kinase (CK), creatine kinase isoenzyme (CK-MB), and troponin I (cTnI) were all lower than those before treatment, and the observation group patients were all lower than the control group (P < 0.05). After treatment, the levels of serum myeloperoxidase (MPO), C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) in the two groups were all lower than those before treatment, and the observation group patients were all lower than the control group (P < 0.05). After treatment, there was no statistical difference between the two groups of patients in cardiogenic death, recurrent myocardial infarction, and other adverse cardiovascular events (P > 0.05). But, the incidence of severe arrhythmia and heart failure in the observation group were both lower than those in the control group (P < 0.05). Kaplan–Meier survival curve analysis showed that the median survival time without MACE in the observation group was higher than that in the control group (P < 0.05). Conclusion. Dapagliflozin treatment for patients with STEMI combined with T2DM after PCI can improve cardiac function to certain extent, reduce inflammation, and will reduce the incidence of adverse cardiovascular outcomes.
Unified Failure Strength Criterion for Terrace Slope Reinforcement Materials
Authors: Fang Xuan , Yang Jie , Na Jia-Ming , Gu Zhen-Yuan
Published: October 2021

This paper presents a study on the failure strength criterion of terrace slope reinforcement materials, such as lean cemented sand and gravel (LCSG) material, under a triaxial stress state. Cement content and confining pressure were selected as major factors to investigate their influence on the peak stress of terrace slope reinforcement materials based on experimental results and data from the literature. The mechanical properties of the LCSG samples, with cement contents of 60, 80, and 90 kg/m3, and noncemented sand and gravel materials were tested under four confining pressure levels (namely, 300, 600, 1000, and 1500 kPa). The results show that the strength of LCSG material improves as the confining pressure increases. When the confining pressure exceeds 1200 kPa, the rate of increase of the strength for LCSG material and other cemented grained materials declines generally. The material strength displays a linear increase with the growth of the cement content. When the axial load rises up to a certain value, damage will occur at the particle cemented site near the shear plane, and the resistance stress generated by the cementation shows a trend of growth first and then attenuation, and concurrently, the friction between particles increases by degrees. Based on the identified strength characteristics of LCSG material under different cement contents and confining pressures, a new strength criterion that incorporates the frictional strengths and the cementing strengths is proposed for LCSG and other similar materials. The results of this work can provide an important theoretical basis for the stability calculation of terrace slopes and LCSG dams.
The Association between COMT Val158Met Polymorphism and the Post-Traumatic Stress Disorder Risk: A Meta-Analysis
Authors: Su Mi , Song Yongyan
Published: October 2021

Background: Genetic factors were suggested to have influence on the development of post-traumatic stress disorder (PTSD). The possible association between catechol-O-methyltransferase (COMT) Val158Met polymorphism and PTSD has been evaluated in several studies. But the results were still controversial. Therefore, we conduct this meta-analysis to address these issues. Methods: The PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched for eligible studies. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to estimate the association between COMT Val158Met polymorphism and PTSD. Results: Five articles including 6 studies with 893 cases and 968 controls were finally included in the present meta-analysis. The pooled analyses did not demonstrate a significant association between the COMT Val158Met polymorphism and PTSD in any of the selected genetic models: allele model (OR = 1.13, 95% CI: 0.97–1.31), dominant model (OR = 1.17, 95% CI: 0.93–1.46), recessive model (OR = 1.44, 95% CI: 0.78–2.66), and additive model (OR = 1.54, 95% CI: 0.85–2.80). Subgroup analyses suggested that the Hardy-Weinberg equilibrium status of genotype distributions could influence the relationship of COMT Val158Met polymorphism and PTSD. Conclusions: The present meta-analysis suggested that the COMT Val158Met polymorphism may not be associated with the PTSD risk. Further large-scale and population-representative studies are warranted to evaluate the impact of the COMT Val158Met polymorphism on the risk of PTSD.
A Novel ATM Gene Mutation Affecting Splicing in an Ataxia-Telangiectasia Patient
Authors: Arslan Ateş Esra , Türkyılmaz Ayberk , Eltan Sevgi Bilgiç , Barış Safa , Güney Ahmet Ilter
Published: October 2021

Ataxia-telangiectasia (AT) is an autosomal recessive disorder characterized by progressive ataxia, choreoathetosis and immunodeficiency beginning in early childhood. An 8-year-old girl was referred with a diagnosis of AT. She had gait disturbance and dysarthria for 3years. Multiple cutaneous telangiectases were observed on her face, trunk and limbs. Sequence analysis of the ATM gene revealed a homozygous c.7308–15A>G mutation in IVS49. Human Splicing Finder predicted that the mutation could activate an intronic cryptic acceptor site. We designed primers for amplification of related exons (48–50) from cDNA for evaluating splicing pattern. Sequencing of ATM exons 48–50 revealed a 14-nucleotide insertion from intron 49, between exons 49 and 50, resulting in premature termination of translation at codon 2439. To conclude, we report a novel mutation in a classical AT case, which resulted in an alternatively spliced transcript and was predicted to form a truncated protein or null protein due to nonsense-mediated decay.
Intragenic Deletion of the ZMYND11 Gene in 10p15.3 is Associated with Developmental Delay Phenotype: A Case Report
Authors: Huynh Minh-Tuan , Tran Cong Toai , Joubert Madeleine , Bénéteau Claire
Published: October 2021

Submicroscopic 10p15.3 microdeletions were previously reported to be associated with developmental delay, and the smallest region of overlap of 10p15.3 deletion including DIP2C and ZMYND11 was defined. Moreover, pathogenic ZMYND11 truncating variants were subsequently identified in a cohort of patients with developmental delay. Of interest, patients harboring 10p15.3 microdeletions or pathogenic ZMYND11 truncating variants share similar clinical features including hypotonia, intellectual disability, facial dysmorphisms, speech and motor delays, seizures, and significant behavioral problems. Only 1 patient with whole ZMYND11 gene deletion was recorded, and no intragenic ZMYND11 deletion was reported up to date. Here, we describe a 7-year-old boy with developmental delay, carrying the smallest de novo 10p15.3 microdeletion, harboring the 5′UTR and the first 2 exons of ZMYND11. Taken together, our report contributes to expand the clinical and mutational spectrum of ZMYND11 and confirms haploinsufficiency as the underlying disease mechanism.
Unexpected Participation of Intercalated Cells in Renal Inflammation and Acute Kidney Injury
Authors: Breton Sylvie , Battistone Maria Agustina
Published: October 2021

Epithelial cells constitute the 1st line of defense against pathogens, and their participation in innate immunity is rapidly emerging. In this mini-review, we discuss the noncanonical role of renal intercalated cells (ICs) in pathogen defense and in the initiation of sterile inflammation. This last function has strong implications in the onset of acute kidney injury (AKI), a potentially fatal medical complication that is seen in hospitalized patients. AKI is associated with inflammation, and it is often diagnosed only after the kidneys have suffered significant and often irreversible damage. While examining the regulation of proton secretion by type A ICs (A-ICs), we unexpectedly found high expression of the pro-inflammatory purinergic receptor P2Y14 in these cells. This receptor is located on the apical surface of A-ICs and binds UDP-glucose (UDP-Glc), a danger-associated molecular pattern molecule released from injured cells that is filtered by the glomeruli and is concentrated in the collecting duct lumen. UDP-Glc activates P2Y14 in A-ICs and triggers the production of chemokines that attract pro-inflammatory immune cells into the kidney stroma and aggravate ischemia-induced proximal tubule injury. Inhibition of P2Y14 or deletion of its gene specifically in ICs in a murine model of ischemia-reperfusion injury attenuated these effects. Thus, together with their previously recognized role in pathogen defense, A-ICs are now recognized as sensors and mediators of renal sterile inflammation that participate in the onset of AKI. Blocking the UDP-Glc/P2Y14 pathway in A-ICs provides new insights into the development of novel AKI therapeutics.
Impact of Muscle Mass on Survival in Patients with Sepsis: A Systematic Review and Meta-Analysis
Authors: Zhang Jiajie , Huang Yicheng , Chen Yingsha , Shen Xiaomin , Pan Hongying , Yu Wei
Published: October 2021

Introduction: The aim of this study is to investigate the association between loss of muscle mass and prognosis of sepsis. Methods: Six databases, including PubMed, Embase, Cochrane Library, Web of Science, Scopus, and Ovid, were searched by the deadline of August 18, 2020. A meta-analysis was conducted on the collected data by means of a random-effects model. The quality of each included article was assessed according to the Newcastle-Ottawa Scale. Results: Out of 1,819 references, 6 articles and 1 conference abstract were included. Sepsis patients with a loss of muscle mass or sarcopenia had higher mortality (risk ratio [RR]: 1.94, 95% confidence intervals [CI]: 1.59–2.37; I-squared = 18.7%, p < 0.001). The RR of mortality within 30 days (RR: 2.31, 95% CI: 1.78–2.99, p < 0.001) was higher than that of mortality over 30 days. Loss of psoas muscle mass, as evaluated by CT, showed the highest RR of sepsis mortality. In addition, based on data on overall survival retrieved from 4 trials, the pooled hazard ratio (HR) for patients with a loss of muscle mass or sarcopenia was 3.04. Subgroup analysis showed that survival time was the main source of heterogeneity for the overall HR. Furthermore, the scanning areas of muscle mass in survival patients were 0.33 cm2/m2 higher than those measured in deceased patients. Conclusion: A loss of muscle mass, as evaluated by CT scan, was associated with a poor outcome in sepsis.
Does Participation in Sport Protect Former Saudi Arabian Athletes from High Blood Glucose after Retirement?
Authors: Altowerqi Zayed Mohammad , bin Zainuddin Zainal Abidin
Published: October 2021

Introduction: The prevalence of type 2 diabetes (T2D) has increased dramatically in the last decades in developed and developing countries. In this regard, the purpose of this study is to investigate the prevalence of prediabetes and diabetes in retired athletes in Saudi Arabia and compare it to nonathletes. This study hypothesizes that early participation in sport can prevent former athletes from abnormal blood glucose levels after retirement. Methods: : The leading methods of researching the issues of the study include the analysis of theoretical sources, analysis of statistics, and comparison. Seventy-three former athletes and 26 nonathletes aged between 20 and 60 years participated in this study. Height, weight, and blood glucose levels were collected by the researcher. The former athletes were divided into 3 groups according to their type of training: endurance, mixed sports, and power sports. Results: The study results showed that 40.59% of former athletes had prediabetes compared to 16.83% of nonathletes. Furthermore, 8.91% of the former athletes had T2D, while 3.96% of the nonathletes had T2D. The results of this study indicated that former athletes had lower average blood glucose than nonathletes. Also, the study results indicated that no statistically significant differences were found between former athletes and nonathletes after retirement. About fasting blood glucose, former power athletes had higher average blood glucose than endurance athletes and mixed sports athletes. Conclusion: It was concluded that no statistically significant differences were found between the former athlete groups.
Audiodescrição fílmica no contexto da formação de tradutores
Authors: Koglin Arlene , Tassara Vitória
Published: October 2021

Este artigo objetiva analisar os desafios encontrados na aplicação prática das diretrizes de audiodescrição brasileira (Minc, 2010) e norte-americanas (2007/2008) no contexto de formação de tradutores. A partir de um estudo de caso, refletimos acerca do processo didático de audiodescrição do curta-metragem “Mariza”. A partir do relato dos aprendizes, observamos como desafios centrais a seleção de informação prioritária, a impossibilidade de neutralidade nas escolhas e a subjetividade de algumas diretrizes.
Corpora de inglês aeronáutico: desafios para o estudo da área e proposta de trabalho conjunto
Authors: Tosqui-Lucks Patricia , Prado Malila Carvalho de Almeida
Published: October 2021

Inglês aeronáutico é o termo empregado para se referir às comunicações que ocorrem entre pilotos e controladores de tráfego aéreo durante os voos em espaço aéreo internacional. Neste artigo, apresentaremos dados de quatro corpora de inglês aeronáutico: dois de comunicações aeronáuticas reais e dois de atividades didáticas envolvendo aprendizes brasileiros, sendo um de pilotos e o outro de controladores. Será discutida a metodologia empregada para a compilação de cada um deles e realizada uma análise contrastiva de termos oriundos dos quatro corpora. Os resultados poderão ser aplicados tanto para informar o desenvolvimento de currículos quanto na elaboração de atividades didáticas voltadas a esses aprendizes, a fim de que desempenhem suas atividades com segurança.
Terminology of Aeronautical Meteorology Codes: a systematization by using corpus
Authors: Peixoto Rafaela Araújo Jordão Rigaud
Published: October 2021

Standardizing terminology is very important to maintain the accuracy of information being disseminated, mainly in specialized fields such as Aeronautical Meteorology. Based on terminology (Pavel; Nolet 2001; Cabré 1999 and 2003) and corpora (Santos 2008 and 2014; Tognini-Bonelli 2011) theoretical foundations, definitions and translation to Portuguese of expressions and terms contained in Table 4678, concerning the main meteorology codes, as prescribed by the World Meteorological Organization (2011), were discussed. As a result, a systematization for terminological procedures is proposed, by using corpora with set validation standards. In this way, this paper intends to contribute to avoid misunderstandings regarding the criticality level of meteorological situations being communicated during air traffic operations.
Metodologias baseadas em corpus para descrição de frames semânticos: desafios e possibilidades
Authors: Santos Aline Nardes dos , Chishman Rove
Published: October 2021

Este artigo discute alguns caminhos metodológicos que têm sido adotados para descrição de frames semânticos com base em corpora. Para isso, parte da noção multifacetada de frame como construto sociocognitivo e como ferramenta analítica, por meio da qual é possível descrever e problematizar as conceptualizações que emergem em contextos sociais. Tendo como base as diferentes perspectivas metodológicas encontradas na literatura, o artigo desemboca de uma proposta delineada para uma tese de doutorado, que realizou um estudo de caso baseado em um corpus de audiências públicas. Como resultados, o artigo aponta para a necessidade de se considerar a pergunta de pesquisa, o tipo de corpus em estudo e o formato dos dados coletados para definição das etapas metodológicas que possibilitam a descrição de frames semânticos em diferentes contextos sociais.
Expressões idiomáticas com a temática alimentação: tradução e glossário de "Pepinos e Abobrinhas", de Márcio Alemão
Authors: Silva Janaína Madeiro da , Teixeira Elisa Duarte
Published: October 2021

Expressões Idomáticas (EIs) são um desafio para aprendizes de língua estrangeiras e de tradução. O objetivo geral deste trabalho foi fazer um estudo contrastivo das EIs encontradas no texto “Pepinos e abobrinhas” (Alemão 2005) ao traduzi-lo para o inglês. Primeiramente buscamos definições e equivalentes em fontes de consulta online e fizemos uma primeira versão da tradução. Em seguida, compilamos um corpus paralelo multiversão com traduções do mesmo texto feitas por outros aprendizes, comparando suas propostas tradutórias com as nossas para produzir uma versão final do texto. As informações coletadas nesse percurso foram organizadas na forma de um glossário, disponível no site do Projeto TermiTraDiCo. Os resultados corroboram nossa hipótese de que estudantes de tradução enfrentam obstáculos ao trabalharem com EIs, particularmente quando são de uma temática específica, seja pela dificuldade de recuperarem seu significado na língua do texto de partida, seja pela ineficiência das fontes de consulta em citá-las e/ou oferecer equivalentes adequados na língua de chegada.
Semantics of ‘hard’ and ‘soft’ in relation to Brexit
Authors: Broz Vlatko
Published: October 2021

This paper analyses the semantics of ‘hardness’ and ‘softness’ in relation to the noun ‘Brexit’ in a news corpus. These concrete descriptions are frequently applied metaphorically to the complex political process of a nation exiting an economic union. First there is a discussion about what other kinds of things can be hard and soft in the NOW (‘News on the Web’) corpus, followed by an analysis of synonyms for hard Brexit and soft Brexit, evaluating their semantic prosody. Only four genuine collocations with the synonyms of hard Brexit have been found in the corpus, whereas seven have been found for soft Brexit. The paper shows how a corpus can be analysed to demonstrate the way in which the semantic prosody of a metaphorical description is negotiated in part through synonyms that exaggerate or mitigate its positive or negative associations.
Investigating the influence of culture on language patterns: a contrastive corpus-based study
Authors: Navarro Sandra
Published: October 2021

This paper aims to explore the intrinsic relationship between language and culture. It attempts to shed light on the underlying cultural associations embedded in collocational meaning across languages. The notion of culture adopted in this study is related to how individuals perceive the world and interpret reality around them. This paper brings together the principles of Corpus Linguistics and Intercultural Studies to investigate a corpus of travelers’ reviews (English/Portuguese) and interpret results within the framework of the model of cultural orientations in Walker et al. (2003). In a study of collocations with the word staff and their equivalents in Portuguese, we demonstrate how a language pattern can also represent a cultural pattern, thus showing that cultural orientations play a role in the identification of collocational meaning across languages.
Corpora e metodologias ativas nas aulas de Prática de Tradução: duas experiências didáticas
Authors: Teixeira Elisa Duarte , Oliveira Joacyr Tupinambás de
Published: October 2021

O uso de ferramentas computadorizadas na tradução vem promovendo uma verdadeira revolução no mercado de trabalho da área. Partindo da hipótese de que o ensino de tradução, pelo menos no Brasil, ainda está à procura de novas maneiras de incorporar essas tecnologias ao ensino e à prática da tradução no ambiente acadêmico, o presente trabalho apresenta duas experiências didáticas envolvendo metodologias ativas e o uso de corpora em disciplinas de Prática de Tradução. Em ambos os casos, os recursos tecnológicos e, em especial, os corpora eletrônicos compilados no decurso do semestre tiveram papel fundamental na dinâmica de trabalho do grupo. As ferramentas computadorizadas facilitaram o processo de aprendizagem e estimularam a aquisição de autoconfiança por parte dos aprendizes.
Responsibility as a factor in the development of family self-determination in adolescence
Authors: Merzlyakova Svetlana V. , Bibarsova Nadia V.
Published: October 2021

Background. National policies and laws determine the speci_cs of family relationship and marriage in di`erent countries. Traditional norms and values that determine the marital and family behavior of young people are weakening with the rapid change in political and economic situation and with the digitalization of society. In this regard it is urgent to study the socio-psychological factors that determine the process of family self-determination in the youth of digital generation. Objective. ae study aims to analyze structural and meaningful characteristics of family self-determination depending on the degree of responsibility among students in adolescence. Sample. ae study involved 326 students of Astrakhan State University aged from 17 to 19 years. aese included 47 (14.4%) male and 279 (85.6%) female students of humanities programmes. Methods. Empirical research was conducted with the use of psychodiagnostic techniques: a modi_ed version of the semantic di`erential methodology by I.L. Solomin, the “Test of life orientations” by D.A. Leontiev, the questionnaire “ae level of the ratio of “value” to “accessibility” in various spheres of life” by E.B. Fantalova, the projective technique “Incomplete sentences”, the questionnaire “Role expectations and claims in marriage” by A.N. Volkova, multidimensional functional diagnostics of responsibility by V.P. Pryadein. Regression analysis made it possible to assess the impact of responsibility on indicators of family self-determination. Results. It is shown that responsibility determines the development of cognitive, value-emotional, regulatory-behavioral, motivational and rebexive components of family self-determination in adolescence. Responsibility has been found to have the greatest impact on the meaningfulness of life (determination coeccient R2 = 0.203) as well as on role claims in the sphere of social activity (R2 = 0.179). Conclusion. Responsibility is a signi_cant micro-level factor determining the process of family self-determination in adolescence. ae development of responsibility among students will allow to form a holistic image “Me as a family person”, to cultivate the values of marriage and family relations and life orientations, to integrate ideas on the time perspective, to reduce the number of extramarital births as a result of the actualization of parenthood as an important marriage motive. Practical application of the results. ae materials of the conducted research can be used in the development and implementation of educational programmes at institutions of higher education. aey can also be used to promote psychological and pedagogical conditions for self-determination in the sphere of marital and family relations through the development of responsibility among modern students.
The role of family relationships in Internet addiction in adolescents
Authors: Kanashov Anton E. , Trusova Anna V.
Published: October 2021

Background. The significant expansion of the Internet over the past few decades has led to new public problems. A broad discussion of the development factors of Internet adduction helps to popularize the idea of the existence of an addictive risk, in particular in the adolescent’s population. The interpersonal characteristics of adolescents and family members can increase vulnerability to Internet addiction. Objective. To analyze the characteristics of the family relations of adolescents in groups with different levels of Internet addiction. Design. The study included 1,119 Internet users – 565 girls and 554 boys between 15 and 18 years of age studying in secondary school in Kopeysk, Chelyabinsk region. Results. The split of the CIAS scale by final score allowed the sample to be divided into 3 subgroups: minimum, moderate and high risk/availability of IA (Internet adduction). There are significant differences in the way adolescents perceive the pedagogical practices of parents: participants with moderate risk of IA more often reported hostility (p < 0.001) and inconsistency (p < 0.001) on the part of the father, also characterized their mother as directive (p = 0.001), hostile (p < 0.001), inconsistent (p < 0.001) and critical (p = 0.010). The minimum risk group noted a more emotional relationship with the father (p = 0.024) and the mother (p = 0.005). In comparisons 1 and 3 the results repeated the inter-group differences of the first two groups, but with the exception of criticism, which was not significant. Groups 2 and 3 were distinguished by inconsistency (p < 0.001) and hostility (p = 0.018) on the part of the mother. Similar results were obtained in the construction of the correlation model. Through step-by-step regression analysis, factors that contribute most to the development of Internet addiction were determined – “Inconsistency (mother)” (p < 0.001). Conclusion. The data show that there are some differences in the way in which parents perceive the pedagogical system in adolescents, with varying levels of Internet addiction.
THE PHENOMENON OF “COMPETENCE”: ASSESSMENT OF THE COMPETENCIES OF MANAGERS (FACTORS OF PREFERENCE)
Authors: Tolochek Vladimir A. , Mashkova Anna S.
Published: October 2021

Background. The study of the application of the competence-based approach in the professional training of specialists in the management sphere remains an urgent issue for many researchers, psychologists, educators and teachers. We began our consideration of this problem in a first approximation in a material published in the previous issue of the journal (Tolochek, 2020). The main issue is to identify the limitations of the competence-based approach as factors of its development and the conditions under which its implementation will be more constructive and effective. It is stated that, in line with the competence-based approach, there remains unresolved issues about the number and content of the qualities of subjects that affect the effectiveness of their activities; on the competencies of subjects performing different labor functions, working in organizations; about the place of competences in the structure of professionalism, about their role in career success. Design: expert surveys, a differentiated and level analysis of frequency matrices of assessments (choices) of competencies by experts. Results. The cycle of studies of competencies and the specifics of their assessment included 69 managers differing in gender, age, seniority, managerial experience, positions in different companies. It was shown that out of 29 competencies, 19 were identified in at least 40% of experts; 8 were identified in at least 66% of experts. Competencies assessed as in demand are associated with individual features, with the evolution of managers as subjects and the characteristics of their activities. Conclusions: 1. Only part of the competencies from the initial list of competencies described by foreign specialists were identified as relevant for managers by experts (employees of Russian companies). Among the competences, there is a “core” of basic, key qualities, and several “belts” (“shells”, “levels”) — less significant (universal) competencies associated with the effective activity of a manager in different areas. 2. Assessments of competencies relevant (important, significant and / or preferred) for managers differ depending on the individual characteristics of experts (gender, age, experience, position, career success, managerial potential) and the length of the list of assessed qualities. 3. Lists of competencies in the range of 15-20 qualities can be considered optimal for solving both scientific and applied problems. The basic list of 29 competencies can be considered “sufficient and redundant”; list of up to 19–20 competencies — “sufficient and necessary”; a list of 8–10 “nuclear” competencies — “essential basic”.
INTERCONNECTION OF METACOGNITION AND EXECUTIVE FUNCTIONS IN CHILDHOOD: CULTURAL-HISTORICAL CONTEXT
Authors: Veraksa A.N. , Veraksa N.E.
Published: October 2021

The review is devoted to the relationship between executive functions and metacognition in the context of a cultural-historical perspective. On the basis of the research carried out over the past 15 years, the commonality and differences of these constructs are shown. Special attention is paid to the development of executive functions and metacognition, their connection with the academic success of children, the role of the social aspect in their formation. The importance of an adult in the directed formation of metacognition and self-regulation is shown, which confirms the provisions of the cultural-historical theory. Within the framework of the cultural-historical paradigm, several mechanisms for the development of executive functions are considered: imitation based on understanding; sign mediation; as well as communication in a social developmental situation. L.S. Vygotsky noted that higher mental functions arise on the basis of real interactions of people, are interiorized, turning into psychological functions. The review showed that one of the most common models of the structure of executive functions is a model that includes such components as “working memory”, “inhibitory control” and “cognitive flexibility”. Based on the analysis, it is possible to assert the influence of J. Piaget’s concept on the development of executive functions. A certain difficulty is caused by the explanation of emotional regulation in the context of metacognitive problems. At the same time, L.S. Vygotsky spoke about the unity of affect and intellect, which suggests the existence behavioral control and, in particular, of emotional processes at the level of metacognitive processes.