bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor necrosis factor‐α polymorphism and risk of primary nephrotic syndrome: A case–control study and meta‐analysis
Authors: Zhao Rongfen , Wang Yufeng , Zhou Yihua , Fan Wu , Yin Haiyan
Published: June 2024

Background

The current study aims to explore the relationship between tumor necrosis factor‐α (TNF‐α) polymorphism and the risk of primary nephrotic syndrome (PNS).

Methods

A total of 250 PNS patients were selected for this study, as well as 300 volunteers serving as the control group. TNF‐α polymorphism were assessed using the polymerase chain reaction‐restriction fragment length polymorphism method. In addition, a meta‐analysis was conducted to analyze previously published literature on this topic.

Results

No significant differences were observed in the genotypes frequency or alleles frequency among the study populations. Meta‐analysis results revealed a positive association between TNF‐α rs1800629 polymorphism and allele contrast in African populations (p = 0), homozygote comparison (p = .007), heterozygote comparison (p = .026), recessive genetic model (p = .011), and dominant genetic model (p = .000).

Conclusions

TNF‐α rs1800629 polymorphism does not appear to confer any increased risk for PNS.
Genetic counselors' professional identity in North America: A scoping review
Authors: Stenberg Kaye , Mills Rachel , Kalia Isha , Schwartz Lisa
Published: June 2024

Professional identity (PI) comprises attributes, beliefs, values, motives, and experiences by which people define themselves in a professional role and evolves through socialization with others in the workplace. While there have been several studies exploring the expanding roles of genetic counselors, few have specifically addressed PI. This scoping review aimed to describe the contexts in which PI has been discussed or examined in the genetic counseling literature. Articles were searched using PubMed, Scopus, and CINAHL with a priori terms including and related to PI. Articles based in the United States or Canada and of all study designs, commentaries, and speeches were included. Date of publication was not restricted. Using social identity theory (SIT) to formulate a definition of PI, multiple reviewers applied inclusion and exclusion criteria to all titles, abstracts, and full‐text articles with conflicts addressed through consensus among all reviewers. A total of 5523 titles and/or abstracts were screened, and 467 full‐text articles were evaluated and categorized as (1) focusing on PI specifically, (2) containing elements of PI although focused on another topic, or (3) not related to PI. Eighty‐seven (87) articles were reviewed during the extraction phase. Ultimately, 41 articles were deemed to meet the agreed upon characteristics of PI. While empirical studies of PI among genetic counselors were limited, PI is being addressed in research focused on related areas, including professional development and diversity, equity, and inclusion, as well as in personal accounts, addresses, and commentaries. Sentiments regarding PI voiced by genetic counselors align with those reported among other health professionals. Given the lack of diversity in the field and rapidly expanding opportunities for genetic counselors, there is risk of some members of the profession feeling excluded, which in turn could negatively impact the collective identity of the profession and translate into impacts on patient care. Additional research regarding the PI of genetic counselors is needed.
HIV self‐testing in India: implementation and qualitative evaluation of a web‐based programme with virtual counsellor support
Authors: Kaptchuk Rose Pollard , Thakker Jalpa , Bell Jade , Okram Saya , Gopinath Usha , Mehta Shruti H. , Reddy Ajay Kumar , Loeb Talia A. , Arumugam Visvanathan , Tandon Samit , Parthasarathy Mugundu Ramien , Ghosh Subash Chandra , Singh Aditya , Joshi Deepika Srivastava , Kaur Sukhvinder , Solomon Sunil Suhas , McFall Allison M.
Published: June 2024

Introduction

To achieve epidemic control of infectious diseases, engaging higher‐burden populations with accessible diagnostic services is critical. HIV self‐testing (HIVST) is a promising option.

Methods

We implemented an online HIVST programme for key populations across India. Eligible clients were 18 years or older, self‐reported a negative or unknown HIV status and reported not taking antiretroviral therapy. Clients who reported a prior HIV diagnosis were not eligible to receive an HIVST kit. HIVST clients received kits via courier or in person at pre‐determined pick‐up points supported by trained counselling staff. Virtual counsellors engaged clients online and by phone and offered support to register, access, and complete HIVST free of cost. Virtual counsellors supported clients to report results and engage with follow‐up services. Follow‐up included linking clients with a positive result to confirmatory testing and HIV care services. We assessed programmatic data across HIV continuum outcomes and conducted a qualitative evaluation through interviews with purposively sampled clients.

Results

Between 30 June 2021 and 30 September 2022, 5324 clients ordered an HIVST kit (76% men, 13% women, 7% transgender people, 4% unknown gender). Of the 4282 clients reporting results (94% of those who received a kit), 6% screened positive, among whom 72% (n = 184) completed confirmatory testing. Themes from 41 client interviews included satisfaction about the convenience and privacy of services and the discreet nature of kit delivery. Respondents were drawn to the convenience of HIVST and appreciated gaining courage and comfort throughout the process from virtual counsellor support. For respondents who screened positive, challenges to care linkage included fearing judgemental questions from public providers and wanting more time before starting treatment. Clients shared concerns about kit accuracy and suggested that instructional materials be provided with more diverse language options.

Conclusions

Web‐based HIVST services with tailored support appeared to facilitate HIV service access and engagement of harder‐to‐reach populations across India. Assistance from a community‐oriented counsellor proved important to overcome literacy barriers and mistrust  in order to support the HIVST process and service linkage. Learnings can inform global efforts to improve the critical step of diagnosis in achieving epidemic control for HIV and other infectious diseases.
Alone together: Post‐traumatic growth during the COVID‐19 pandemic shelter‐in‐place phase
Authors: Metz Anne L. , Daniels Judy
Published: June 2024

The primary objective of this study was to explore posttraumatic growth in adults who lived alone during the shelter‐in‐place (SIP) phase of the pandemic. Semistructured interviews were conducted with nine adults between the ages of 33 and 56 several weeks into SIP. Transcripts were analyzed using thematic analysis. Five themes emerged from participant interviews: connection, prior recent hardship, gratitude, spiritual practice, and relationship with self. By exploring the experiences of those who thrived while living alone during the SIP phase, this study aimed to provide a nuanced understanding of the psychological processes underlying positive adaptation amidst crisis. Our findings highlight the importance of fostering connections, both interpersonal and intrapersonal, as a means of promoting resilience and growth during times of crisis. The themes of gratitude, spiritual practice, and a positive relationship with self underscore the significance of existential and humanistic concepts, such as meaning‐making, self‐reflection, and personal growth.
Four theories to empower black men's existence: Meaning making in dehumanizing contexts
Authors: Shannon Jordan , Shell E Mackenzie , Loury Jacoby , Bayne Hannah B.
Published: June 2024

Most theories used to explore existential realities of clients were developed and informed by White Eurocentric philosophers, who overlooked the impact of race and racism on identity. At a time when Black men continue to experience threats to their survival, such as through the epidemics of racial violence and health disparities of COVID‐19, it is critical for professional counselors to appropriately incorporate racial and gendered perspectives into existential conceptualizations of client experience. In this paper, we identify four theoretical frameworks for clinicians to adopt in working with Black men's existential realities: Black existentialism, Black liberation narrative therapy, critical race theory, and radical healing psychotherapy. We locate these theories within the context of impacts from the dual pandemics of racial trauma and COVID‐19, applying mini‐vignettes to demonstrate how each theory can be responsive to the existential needs of Black men.
The minimal important change is not a universal fixed value across diagnoses when using the FAOS and FAAM in patients undergoing elective foot and ankle surgery
Authors: Sierevelt Inger N. , van Kampen Paulien M. , Terwee Caroline B. , Nolte Peter A. , Kerkhoffs Gino M. M. J. , Haverkamp Daniel ,   Dutch Foot and Ankle Outcome Study Group
Published: June 2024

Purpose

This study aimed to calculate region and diagnosis‐specific minimal important changes (MICs) of the Foot and Ankle Outcome Score (FAOS) and the Foot and Ankle Ability Measure (FAAM) in patients requiring foot and ankle surgery and to assess their variability across different foot and ankle diagnoses.

Methods

The study used routinely collected data from patients undergoing elective foot and ankle surgery. Patients had been invited to complete the FAOS and FAAM preoperatively and at 3–6 months after surgery, along with two anchor questions encompassing change in pain and daily function. Patients were categorised according to region of pathology and subsequent diagnoses. MICs were calculated using predictive modelling (MICPRED) and receiver operating characteristic curve (MICROC) method and evaluated according to strict credibility criteria.

Results

Substantial variability of the MICs between forefoot and ankle/hindfoot region was observed, as well as among specific foot and ankle diagnoses, with MICPRED and MICROC values ranging from 7.8 to 25.5 points and 9.4 to 27.8, respectively. Despite differences between MICROC and MICPRED estimates, both calculation methods exhibited largely consistent patterns of variation across subgroups, with forefoot conditions systematically showing smaller MICs than ankle/hindfoot conditions. Most MICs demonstrated high credibility; however, the majority of the MICs for the FAOS symptoms subscale and forefoot conditions exhibited insufficient or low credibility.

Conclusion

The MICs of the FAOS and FAAM vary across foot and ankle diagnoses in patients undergoing elective foot and ankle surgery and should not be used as a universal fixed value, but recognised as contextual parameters. This can help clinicians and researchers in more accurate interpretation of the FAOS and FAAM change scores.

Level of Evidence

Level IV.
Warning signals for mental health problems in at‐risk young adults may be informed by momentary emotions reported by the general population: A novel application of the principles of statistical process control
Authors: Schreuder Marieke J. , Kuppens Peter , Schat Evelien , de Jonge Peter , Hartman Catharina A. , Ceulemans Eva
Published: June 2024

Statistical process control (SPC) was recently introduced as a method for detecting person‐specific warning signals for mental ill‐health. Such warning signals occur when a person's repeatedly assessed emotions exceed a control limit. This control limit should in principle be based on the same person's emotions in a healthy period. As such data are often unavailable, this preregistered study investigated whether general population data can be used instead to estimate control limits. We used data from the HowNutsAreTheDutch study, in which adults from the general population (N = 746) rated their emotions three times a day for 1 month. Based on these data, we computed control limits according to the exponentially weighted moving average (EWMA) and Shewhart SPC methods. Next, we investigated how often young adults with versus without persistent mental health problems from the TRAILS TRANS‐ID study (N = 100)–who rated their emotions daily for 6 months–reported scores beyond these general population‐based control limits. Generally, warning signals occurred more often in young adults with persistent mental health problems compared to healthy young adults (p < 0.05). The predictive performance of SPC did not consistently improve when control limits were conditioned on individuals' age, sex, and depressive symptoms, nor differ between methods (EWMA vs. Shewhart). The different emotions that were monitored, however, affected SPC performance, so that for most settings, warning signs in feeling tired and upset were worse for detecting mental‐ill health compared to warning signs in other emotions (e.g., feeling nervous, relaxed, etc.).  It follows that warning signs in individual's emotions can perhaps be monitored using relatively generic norms, derived from the general population, opening up new avenues for research and low‐threshold clinical application.
Palate Shape, Drug‐Induced Sleep Endoscopy Findings, and Obstructive Sleep Apnea Pharyngeal Surgery Outcomes
Authors: Commesso Emily A. , Kedarisetty Suraj , Kita Ashley E. , Sharma Abhay , Woodson B. Tucker , Green Katherine K. , Kent David T. , D'Agostino Mark A. , Kezirian Eric J.
Published: June 2024

Objective

Pharyngeal surgery is a treatment option for patients with obstructive sleep apnea (OSA) unable to tolerate positive pressure therapy. This study aims to determine the association between palate shape as described by Woodson and pharyngeal surgical outcomes.

Study Design

Exploratory analysis of retrospective cohort.

Setting

Multicenter.

Methods

Three blinded reviewers assessed palate shape using drug‐induced sleep endoscopy (DISE) videos from a previously‐assembled cohort of adults undergoing pharyngeal surgery. Palate shape scores were examined for association with surgical outcomes with univariate and multivariate analyses. Multivariate analyses included adjustment for consensus DISE findings determined previously.

Results

Two hundred nine study subjects were included from 13 centers. Age was 53.7 ± 11.5 years, body mass index (BMI) was 30.3 ± 5.0 kg/m2, and 21% were female. In isolated soft palate surgery, greater GenuAP narrowing was associated with lesser odds of surgical response, whereas greater GenuLW narrowing was associated with greater odds of surgical response. These findings largely persisted after adjustment for key DISE findings, age, gender, OSA severity, BMI, and tonsil size. Other palate‐shape findings were not clearly associated with surgical outcomes, although some palate‐shape findings demonstrated trends toward an association with outcomes (P < .10).

Conclusion

Greater GenuAP narrowing and GenuLW narrowing were associated with lesser and greater, respectively, odds of surgical response after isolated soft palate surgery. Palate shape and other palate shape level scores were not clearly associated with surgical outcomes. Larger studies may determine more precisely the association between palate shape and pharyngeal surgery outcomes.
Laryngeal microsurgery under Transnasal Humidified Rapid Insufflation Ventilatory Exchange
Authors: Rigal Tiffany , Baudouin Robin , Circiu Marta , Couineau Florent , Lechien Jérôme , Crevier‐Buchman Lise , Le Guen Morgan , Hans Stéphane
Published: June 2024

Objective

Since 2015, Transnasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) has been used in general anesthesia for preoxygenation or difficult exposure airway management. Its use offers new opportunities in laryngology. THRIVE increases apnea time and frees the access to the upper airway. However, its use may be less stable than orotracheal intubation. The main objective of this work was to evaluate the feasibility of laryngeal microsurgery under THRIVE including using Laser.

Study Design

Retrospective.

Setting

A total of N = 99 patients with laryngeal microsurgery (with or without CO2 laser) under THRIVE were included successively from January 1, 2020 to January 30, 2022.

Method

Medical history, comorbidities, clinical and surgical data were extracted and analyzed. Two groups were constituted regarding the “success” (use of THRIVE along all the procedure) or the “failure” (need for an endotracheal tube) of the use of THRIVE during the procedure.

Results

A failure occurred in N = 15/99 patients (15.2%) mainly due to refractory hypoxia. The odd ratios (OR) for THRIVE failure were: OR = 6.6 [2.9‐35] for overweight (BMI >25 kg/m2); OR = 3.8 [1.7‐18.7] for ASA score >2; OR = 4.7 [2.3‐24.7] for the use of CO2 laser. Elderly patients and patients with pulmonary pathology were not statistically at greater risk of THRIVE failure. No adverse event was described.

Conclusion

This work confirms the feasibility of laryngeal microsurgery under THRIVE, including with CO2 laser. Overweight, ASA >2 and lower fraction of inspired oxygen during CO2 laser use increased the risk for orotracheal intubation.
UAV data and deep learning: efficient tools to map ant mounds and their ecological impact
Authors: Monsimet Jérémy , Sjögersten Sofie , Sanders Nathan J. , Jonsson Micael , Olofsson Johan , Siewert Matthias
Published: June 2024

High‐resolution unoccupied aerial vehicle (UAVs) data have alleviated the mismatch between the scale of ecological processes and the scale of remotely sensed data, while machine learning and deep learning methods allow new avenues for quantification in ecology. Ant nests play key roles in ecosystem functioning, yet their distribution and effects on entire landscapes remain poorly understood, in part because they and their mounds are too small for satellite remote sensing. This research maps the distribution and impact of ant mounds in a 20 ha treeline ecotone. We evaluate the detectability from UAV imagery using a deep learning model for object detection and different combinations of RGB, thermal and multispectral sensor data. We were able to detect ant mounds in all imagery using manual detection and deep learning. However, the highest precision rates were achieved by deep learning using RGB data which has the highest spatial resolution (1.9 cm) at comparable UAV flight height. While multispectral data were outperformed for detection, it allows for novel insights into the ecology of ants and their spatial impact on vegetation productivity using the normalized difference vegetation index. Scaling up, this suggests that ant mounds quantifiably impact vegetation productivity for up to 4% of our study area and up to 8% of the Betula nana vegetation communities, the vegetation type with the highest abundance of ant mounds. Therefore, they could have an overlooked role in nutrient‐limited tundra vegetation, and on the shrubification of this habitat. Further, we show the powerful combination UAV multi‐sensor data and deep learning for efficient ecological tracking and monitoring of mound‐building ants and their spatial impact.
Odontogenesis‐Empowered Extracellular Vesicles Safeguard Donor‐Recipient Stem Cell Interplay to Support Tooth Regeneration
Authors: Huang Xiaoyao , Sui Bingdong , Liu Anqi , Guo Hao , Zheng Chenxi , Liu Peisheng , Cai Xinyue , Fu Fei , Bai Shengfeng , Jin Fang , Chen Ji , Wei Changze , Jin Yan , Xuan Kun
Published: June 2024

Harnessing the developmental events of mesenchymal condensation to direct postnatal dental stem cell aggregation represents a cutting‐edge and promising approach to tooth regeneration. Tooth avulsion is among the most prevalent and serious dental injuries, and odontogenic aggregates assembled by stem cells from human exfoliated deciduous teeth (SHED) have proven effective in revitalizing avulsed teeth after replantation in the clinical trial. However, whether and how SHED aggregates (SA) communicate with recipient components and promote synergistic tissue regeneration to support replanted teeth remains elusive. Here, it is shown that SA‐mediated avulsed tooth regeneration involves periodontal restoration and recovery of recipient Gli1+ stem cells, which are mobilized and necessarily contribute to the reestablishment of the tooth‐periodontal ligament‐bone interface. Mechanistically, the release of extracellular vesicles (EVs) is revealed indispensable for the implanted SA to mobilize recipient Gli1+ cells and regenerate avulsed teeth. Furthermore, SHED aggregates‐released EVs (SA‐EVs) are featured with odontogenic properties linked to tissue regeneration, which enhance migration, proliferation, and differentiation of Gli1+ cells. Importantly, local application of SA‐EVs per se empowers recipient Gli1+ cells and safeguards regeneration of avulsed teeth. Collectively, the findings establish a paradigm in which odontogenesis‐featured EVs govern donor‐recipient stem cell interplay to achieve tooth regeneration, inspiring cell‐free translational regenerative strategies.
Molten Salt‐Assisted Synthesis of Titanium Nitride
Authors: Parvizian Mahsa , Reichholf Nico , Riaz Aysha A. , Bhatt Prajna , Regoutz Anna , De Roo Jonathan
Published: June 2024

Titanium nitride is an exciting plasmonic material, with optical properties similar to gold. However, synthesizing TiN nanocrystals is highly challenging and typically requires solid‐state reactions at very high temperatures (800–1000°C). Here, the synthesis of TiN nanocrystals is achieved at temperatures as low as 350°C, in just 1 h. The strategy comprises molten salt, Mg as reductant and Ca3N2 as nitride source. This brings TiN from the realm of solid‐state chemistry into the field of solution‐based synthesis in regular, borosilicate glassware.
Qualitative analysis of online discussion boards for male urinary incontinence after prostate treatment
Authors: Fernandez Adrian , Abbasi Behzad , Sudhakar Architha , Shieh Christine , Hampson Lindsay A. , Lui Jason L. , Ghaffar Umar , Patel Hiren , Shaw Nathan M. , Breyer Benjamin N.
Published: June 2024

Introduction

Though urinary incontinence (UI) after prostate treatment often contributes to emotional distress and significantly impacts quality of life, many patients do not discuss this condition with their physicians. We analyzed the patient perspective by examining online support group posts to gain insight into specific challenges associated with different UI management methods.

Methods

We examined discussion board threads from multiple patient‐focused forums on experiences of UI due to prostate treatment (threads from January 2016 to January 2022). Principles of grounded theory in thematic analysis were used to analyze the threads.

Results

Three hundred and eighteen posts from 84 unique users were analyzed. Among users, 47 (56%) reported UI following radical prostatectomy (RP), 5 (6%) secondary to radiation therapy (RT), 12 (14%) after a combination of RP and RT, and 20 (24%) were ambiguous. UI management methods included pads/diapers/liners, condom catheters/external clamps, Kegels/pelvic floor physiotherapy, and surgical treatment (artificial urinary sphincter or sling placement). We identified challenges common to all management methods: “requires trial and error,” “physical discomfort,” and “difficult to be in public.” Factors influencing management choices included the ability to “feel normal” and the development of a management routine.

Conclusion

The current study identifies opportunities for improved expectation‐setting and education regarding post‐procedural UI and its management. These findings can serve as a guide for providers to counsel patients on the advantages and disadvantages of UI management devices.
Enabling Coherence Between Energy Policies and SDGs Through Open Energy Models: The TEMOA-Italy Example
Authors: Nicoli Matteo , Alfano Maria Elena , Amir Kavei Farzaneh , Balbo Alessandro , Colucci Gianvito , Lerede Daniele , Mosso Daniele , Savoldi Laura
Published: June 2024

This chapter highlights the significance of open-source energy system optimization models in enhancing the transparency and accessibility of energy system studies for policymakers. It provides a detailed example of the creation of a robust modeling framework. This includes guidance on selecting appropriate inputs, interpreting results, and connecting them to policy-relevant objectives such as the Sustainable Development Goals (SDGs), particularly SDGs 6 (water), 7 (energy), 8 (work and economic growth), 9 (industry), 13 (climate) and 15 (land). The focus is on the energy system optimization model TEMOA-Italy, a case study for Italy developed within the open-source framework TEMOA. The presented results explore the impact of possible future scenarios and energy policies on the power sector’s sustainability, showing that low emissions scenarios perform better than a base scenario concerning environmental aspects, but worse in terms of land use and social aspects like the quality of labor. Import dependence is also affected by the renewables’ penetration, due to the criticality of renewable technologies imports. The exclusion of carbon capture from the set of available new technologies improves geopolitical stability and reduces volume shortage risk.
Primordial black holes from slow phase transitions: a model-building perspective
Authors: Kanemura Shinya , Tanaka Masanori , Xie Ke-Pan
Published: June 2024

Abstract

We investigate the formation of primordial black holes (PBHs) through delayed vacuum decay during slow cosmic first-order phase transitions. Two specific models, the polynomial potential and the real singlet extension of the Standard Model, are used as illustrative examples. Our findings reveal that models with zero-temperature scalar potential barriers are conducive to the realization of this mechanism, as the phase transition duration is extended by the U-shaped Euclidean action. We find that the resulting PBH density is highly sensitive to the barrier height, with abundant PBH formation observed for sufficiently high barriers. Notably, the phase transition needs not to be ultra-supercooled (i.e. the parameter α ≫ 1), and the commonly used exponential nucleation approximation Γ(t) ~ eβt fails to capture the PBH formation dynamics in such models.
Incorporating DDπ effects and left-hand cuts in lattice QCD studies of the Tcc(3875)+
Authors: Hansen Maxwell T. , Romero-López Fernando , Sharpe Stephen R.
Published: June 2024

Abstract

We generalize the relativistic field-theoretic three-particle finite-volume scattering formalism to describe generic DDπ systems in the charm C = 2 sector. This includes the isospin-0 channel, in which the recently discovered doubly-charmed tetraquark Tcc(3875)+ is expected to manifest as a pole in the DDπ → DDπ scattering amplitude. The formalism presented here can also be applied to lattice QCD settings in which the D* is bound and, in particular, remains valid below the left-hand cut in DD* scattering, thus resolving an issue in previous analyses of lattice-determined finite-volume energies.
Six-dimensional correlators from a five-dimensional operator product expansion
Authors: Lambert N. , Lipstein A. , Mouland R.
Published: June 2024

Abstract

In this letter we discuss the operator product expansion of scalar operators in five-dimensional field theories with an SU(1, 3) × U(1) spacetime symmetry. Such theories arise by a novel conformal null reduction of six-dimensional Lorentzian conformal field theories. Unlike Lorentzian conformal field theories, three-point functions of generic operators in such theories are not completely fixed by SU(1, 3) × U(1) symmetry. However, we show that in a special case the functional form of the OPE coefficients can be fully determined, and we use them to fix the form of the three-point function. The result is shown to agree with correlation functions obtained by reduction of six-dimensional conformal field theories.
Psychische Belastungen bei Erwerbstätigen: Leistungsinanspruchnahme und Kosten für das deutsche Gesundheitssystem
Authors: Mulfinger Nadine , Angerer Peter , Erim Yesim , Hander Nicole , Hansmann Marieke , Herold Regina , Kilian Reinhold , Kröger Christoph , Rothermund Eva , Weber Jeannette ,   friaa-Studiengruppe, Brezinski Jolanda , Feisst Manuel , Kohl Fiona , Heming Meike , Gündel Harald , Herrmann Kristin , Seega Rike , Hondong Sinja , Brenner Lorena , Chrysanthou Sophia , Köllner Volker , Stegmann Ralf , Schröder Ute B. , Wegewitz Uta , Waldmann Tamara
Published: June 2024

Einleitung

Die Inanspruchnahme von Leistungen durch Arbeitnehmer:innen mit psychischen Belastungen sowie die damit verbundenen Kosten im Gesundheits- und Sozialsystem wurden bisher nicht systematisch in Studien erhoben bzw. nur indirekt erfasst. Diese Publikation hat zum Ziel, die Inanspruchnahme in dieser Zielgruppe zu dokumentieren, die Kosten im Gesundheits- und Sozialsystem erstmalig abzuschätzen und mögliche Einflussfaktoren der Kostenvarianz zu untersuchen.

Methodik

Als Teil einer Multicenter-Studie wurden Häufigkeiten der Inanspruchnahme sowie Kosten im Gesundheits- und Sozialsystem von 550 Arbeitnehmer:innen mit psychischen Belastungen erhoben. Die Inanspruchnahme von Leistungen wurde mit der deutschen Version des Client Sociodemographic Service Receipt Inventory (CSSRI) erhoben. Kosten wurden für 6 Monate berechnet. Mithilfe eines Regressionsmodells wurden Einflussfaktoren auf die Kosten überprüft.

Ergebnisse

Zu Studienbeginn betrugen die durchschnittlichen Gesamtkosten der vergangenen 6 Monate in der Stichprobe € 5227,12 (Standardabweichung € 7704,21). Das Regressionsmodell weist auf einen signifikanten Anstieg der Kosten mit zunehmendem Alter sowie bei Personen mit Depressionen, Verhaltensauffälligkeiten mit körperlichen Symptomen und anderen Diagnosen hin.

Diskussion

Die berechneten Kosten sind im Vergleich zu klinischen Stichproben ähnlich hoch. Des Weiteren sollte zukünftig untersucht werden, ob sich dieses Ergebnis durch die Analyse der Längsschnittdaten verändert und ob die Intervention einen Kosteneinfluss aufweist.
Genetic control of rhizosphere microbiome of the cotton plants under field conditions
Authors: Wei Feng , Feng Zili , Yang Chuanzhen , Zhao Lihong , Zhang Yalin , Zhou Jinglong , Feng Hongjie , Zhu Heqin , Xu Xiangming
Published: June 2024

Understanding the extent of heritability of a plant-associated microbiome (phytobiome) is critically important for exploitation of phytobiomes in agriculture. Two crosses were made between pairs of cotton cultivars (Z2 and J11, L1 and Z49) with differential resistance to Verticillium wilt. F2 plants were grown in a field, together with the four parents to study the heritability of cotton rhizosphere microbiome. Amplicon sequencing was used to profile bacterial and fungal communities in the rhizosphere. F2 offspring plants of both crosses had higher average alpha diversity indices than the two parents; parents differed significantly from F2 offspring in Bray–Curtis beta diversity indices as well. Two types of data were used to study the heritability of rhizosphere microbiome: principal components (PCs) and individual top microbial operational taxonomic units (OTUs). For the L1 × Z49 cross, the variance among the F2 progeny genotypes (namely, genetic variance, VT) was significantly greater than the random variability (VE) for 12 and 34 out of top 100 fungal and bacterial PCs, respectively. For the Z2 × J11 cross, the corresponding values were 10 and 20 PCs. For 29 fungal OTUs and 10 bacterial OTUs out of the most abundant 100 OTUs, genetic variance (VT) was significantly greater than VE for the L1 × Z49 cross; the corresponding values for the Z2 × J11 cross were 24 and one. The estimated heritability was mostly in the range of 40% to 60%. These results suggested the existence of genetic control of polygenic nature for specific components of rhizosphere microbiome in cotton.

Key points

• F2offspring cotton plants differed significantly from parents in rhizosphere microbial diversity.

• Specific rhizosphere components are likely to be genetically controlled by plants.

• Common PCs and specific microbial groups are significant genetic components between the two crosses.
Comparative genomics reveals insights into the potential of Lysinibacillus irui as a plant growth promoter
Authors: Hilário Sandra , Gonçalves Micael F. M. , Matos Inês , Rangel Luis F. , Sousa José A. , Santos Maria J. , Ayra-Pardo Camilo
Published: June 2024

Members of the genus Lysinibacillus attract attention for their mosquitocidal, bioremediation, and plant growth-promoting abilities. Despite this interest, comprehensive studies focusing on genomic traits governing plant growth and stress resilience in this genus using whole-genome sequencing are still scarce. Therefore, we sequenced and compared the genomes of three endophytic Lysinibacillus irui strains isolated from Canary Island date palms with the ex-type strain IRB4-01. Overall, the genomes of these strains consist of a circular chromosome with an average size of 4.6 Mb and a GC content of 37.2%. Comparative analysis identified conserved gene clusters within the core genome involved in iron acquisition, phosphate solubilization, indole-3-acetic acid biosynthesis, and volatile compounds. In addition, genome analysis revealed the presence of genes encoding carbohydrate-active enzymes, and proteins that confer resistance to oxidative, osmotic, and salinity stresses. Furthermore, pathways of putative novel bacteriocins were identified in all genomes. This illustrates possible common plant growth-promoting traits shared among all strains of L. irui. Our findings highlight a rich repertoire of genes associated with plant lifestyles, suggesting significant potential for developing inoculants to enhance plant growth and resilience. This study is the first to provide insights into the overall genomic signatures and mechanisms of plant growth promotion and biocontrol in the genus Lysinibacillus.

Key points

• Pioneer study in elucidating plant growth promoting in L. irui through comparative genomics.

• Genome mining identified biosynthetic pathways of putative novel bacteriocins.

• Future research directions to develop L. irui-based biofertilizers for sustainable agriculture.
Early and selective localization of tau filaments to glutamatergic subcellular domains within the human anterodorsal thalamus
Authors: Sárkány Barbara , Dávid Csaba , Hortobágyi Tibor , Gombás Péter , Somogyi Peter , Acsády László , Viney Tim J.
Published: June 2024

Widespread cortical accumulation of misfolded pathological tau proteins (ptau) in the form of paired helical filaments is a major hallmark of Alzheimer’s disease. Subcellular localization of ptau at various stages of disease progression is likely to be informative of the cellular mechanisms involving its spread. Here, we found that the density of ptau within several distinct rostral thalamic nuclei in post-mortem human tissue (n = 25 cases) increased with the disease stage, with the anterodorsal nucleus (ADn) consistently being the most affected. In the ADn, ptau-positive elements were present already in the pre-cortical (Braak 0) stage. Tau pathology preferentially affected the calretinin-expressing subpopulation of glutamatergic neurons in the ADn. At the subcellular level, we detected ptau immunoreactivity in ADn cell bodies, dendrites, and in a specialized type of presynaptic terminal that expresses vesicular glutamate transporter 2 (vGLUT2) and likely originates from the mammillary body. The ptau-containing terminals displayed signs of degeneration, including endosomal/lysosomal organelles. In contrast, corticothalamic axon terminals lacked ptau. The data demonstrate the involvement of a specific cell population in ADn at the onset of the disease. The presence of ptau in subcortical glutamatergic presynaptic terminals supports hypotheses about the transsynaptic spread of tau selectively affecting specialized axonal pathways.
Multisensory Extended Reality Applications Offer Benefits for Volumetric Biomedical Image Analysis in Research and Medicine
Authors: Krieger Kathrin , Egger Jan , Kleesiek Jens , Gunzer Matthias , Chen Jianxu
Published: June 2024

3D data from high-resolution volumetric imaging is a central resource for diagnosis and treatment in modern medicine. While the fast development of AI enhances imaging and analysis, commonly used visualization methods lag far behind. Recent research used extended reality (XR) for perceiving 3D images with visual depth perception and touch but used restrictive haptic devices. While unrestricted touch benefits volumetric data examination, implementing natural haptic interaction with XR is challenging. The research question is whether a multisensory XR application with intuitive haptic interaction adds value and should be pursued. In a study, 24 experts for biomedical images in research and medicine explored 3D medical shapes with 3 applications: a multisensory virtual reality (VR) prototype using haptic gloves, a simple VR prototype using controllers, and a standard PC application. Results of standardized questionnaires showed no significant differences between all application types regarding usability and no significant difference between both VR applications regarding presence. Participants agreed to statements that VR visualizations provide better depth information, using the hands instead of controllers simplifies data exploration, the multisensory VR prototype allows intuitive data exploration, and it is beneficial over traditional data examination methods. While most participants mentioned manual interaction as the best aspect, they also found it the most improvable. We conclude that a multisensory XR application with improved manual interaction adds value for volumetric biomedical data examination. We will proceed with our open-source research project ISH3DE (Intuitive Stereoptic Haptic 3D Data Exploration) to serve medical education, therapeutic decisions, surgery preparations, or research data analysis.
Simultaneous hydrogen production and photocatalytic pollutant removal: a review
Authors: Kumar Amit , Sharma Pankaj , Sharma Gaurav , Dhiman Pooja , Mola Genene Tessema , Farghali Mohamed , Rashwan Ahmed K. , Nasr Mahmoud , Osman Ahmed I. , Wang Tongtong
Published: June 2024

Pollution and the rising energy demand are two major society issues, requiring urgent solutions. Here, we review the simultaneous production of hydrogen and removal of pollutants, with a focus on mechanisms, synthesis of photocatalysts, and applications. Remarkably, this method utilizes organic pollutants as sacrificial agents for photocatalytic hydrogen production, thus both reducing pollution and producing energy. Metal-doped, cocatalyst-loaded, organic and inorganic composite, heterostructure and heterojunction photocatalysts are described. We present applications to the removal of antibiotics and organic dyes. Pollutant degradation rates range from 5.3 to 100%, with hydrogen evolution of 13.7–2724.89 μmol·g–1h–1.
Exposure to Violence and Mental Health Outcomes Among Pre-schoolers in a South African Birth Cohort
Authors: Tsunga Lucinda , Heron Jon , Lake Marilyn T. , Halligan Sarah L. , Malcolm-Smith Susan , Hoffman Nadia , Zar Heather J. , Fraser Abigail , Stein Dan J. , Donald Kirsten A.
Published: June 2024

Little is known about the relationship between violence exposure and mental health in preschoolers living in low- and middle-income countries (LMICs). Multiple regression analyses investigated associations between violence exposure and mental health in the Drakenstein Child Health Study (N = 978), a South African birth cohort. Lifetime violence exposure was assessed at age 4.5 years using the parent-report Child Exposure to Community Violence Checklist (CECV). Mental health was assessed at age 5 years using the Child Behaviour Checklist (CBCL 1.5–5). Eighty-three percent of the children were exposed to some form of violence. Internalising and externalising behaviours were positively associated with overall violence exposure (β per one unit change in the overall score = 0.55 [0.16, 0.94] and β = 0.53 [0.23, 0.84], respectively), domestic victimisation (β per one unit change in the subscore = 1.28 [0.28, 2.27]; β = 1.14 [0.37, 1.90]) and witnessing community violence (β = 0.77 [0.15, 1.39]; β = 0.68 [0.19, 1.18]). There was a positive association between polyvictimisation and externalising (β = 1.02 [0.30, 1.73]) but not internalising (β = 0.87 [-0.06, 1.80]) behaviour problems. Evidence for an association of witnessing domestic violence with internalising (β = 0.63 [-0.97, 2.24]) or externalising (β = 1.23 [-0.04, 2.50]) behaviours was less robust. There was no association between community victimisation and internalising or externalising behaviours (β = 0.72 [-1.52, 2.97; β = 0.68 [ -1.06, 2.41]). Observations highlight the risk for mental health problems among preschoolers living in high-violence contexts and emphasize the need for early interventions.
Prevalence, Indications, and Complications of Conversional Surgery After Vertical Banded Gastroplasty: A MBSAQIP Analysis
Authors: Barajas-Gamboa Juan S. , Duran Valentina , Romero-Velez Gustavo , Mocanu Valentin , Lee Yung , Corcelles Ricard , Allemang Matthew , Strong Andrew T. , Navarrete Salvador , Rodriguez John , Kroh Matthew , Dang Jerry T.
Published: June 2024

Purpose

Vertical banded gastroplasty (VBG) was once the most popular bariatric procedure in the 1980’s, with many patients subsequently requiring conversional surgery. However, knowledge regarding the prevalence and outcomes of these procedures remains limited. This study aims to determine the prevalence, indications, rate of 30-day serious complications, and mortality of conversional surgery after VBG.

Materials and Methods

A retrospective analysis of the MBSAQIP database from 2020 to 2022 was conducted. Individuals undergoing conversional or revisional surgery after VBG were included. The primary outcomes were 30-day serious complications and mortality.

Results

Of 716 VBG conversions, the common procedures included 660 (92.1%) Roux-en-Y gastric bypass (RYGB) and 56 (7.9%) sleeve gastrectomy (SG). The main indication for conversion was weight gain for RYGB (31.0%) and for SG (41.0%). RYGB had longer operative times than SG (223.7 vs 130.5 min, p < 0.001). Although not statistically significant, serious complications were higher after RYGB (14.7% vs 8.9%, p = 0.2). Leak rates were higher after SG (5.4 vs 3.5%) but this was not statistically significant (p = 0.4). Mortality was similar between RYGB and SG (1.2 vs 1.8%, p = 0.7). Multivariable regression showed higher body mass index, longer operative time, previous cardiac surgery and black race were independently associated with serious complications. Conversion to RYGB was not predictive of serious complications compared to SG (OR 0.96, 95%CI 0.34–2.67, p = 0.9).

Conclusions

Conversional surgery after VBG is uncommon, and the rate of complications and mortality remains high. Patients should be thoroughly evaluated and informed about these risks before undergoing conversion from VBG.
The Pathophysiology, Prognosis and Treatment of Hypertension in Females from Pregnancy to Post-menopause: A Review
Authors: Li Simeng , Tan Isabella , Atkins Emily , Schutte Aletta E , Gnanenthiran Sonali R
Published: June 2024

Purpose of Review

We summarise the physiological changes and risk factors for hypertension in females, potential sex-specific management approaches, and long-term prognosis.

Key Findings

Pregnancy and menopause are two key phases of the life cycle where females undergo significant biological and physical changes, making them more prone to developing hypertension. Gestational hypertension occurs from changes in maternal cardiac output, kidney function, metabolism, or placental vasculature, with one in ten experiencing pregnancy complications such as intrauterine growth restriction and delivery complications such as premature birth. Post-menopausal hypertension occurs as the protective effects of oestrogen are reduced and the sympathetic nervous system becomes over-activated with ageing. Increasing evidence suggests that post-menopausal females with high blood pressure (BP) experience greater risk of cardiovascular events at lower BP thresholds, and greater vulnerability to treatment-related adverse effects.

Hypertension is a key risk factor for cardiovascular disease in females. Current BP treatment guidelines and recommendations are similar for both sexes, without addressing sex-specific factors. Future investigations into ideal diagnostic thresholds, BP control targets and treatment regimens in females are needed.
Highly dispersive optical solitons with differential group delay and multiplicative white noise for Fokas–Lenells equation
Authors: Zayed Elsayed M. E. , Arnous Ahmed H. , Biswas Anjan , Yildirim Yakup , Rawal Bharat S. , Moraru Luminita , Alshomrani Ali Saleh
Published: June 2024

The current article addresses highly dispersive optical solitons with polarization mode dispersion, modeled by the Fokas–Lenells equation in presence of white noise. The corresponding soliton solutions are retrieved with the usage of two integration algorithms. They are the enhanced Kudryashov’s method and the enhanced direct algebraic method. The intermediary solutions are in terms of Jacobi’s elliptic functions and Weierstrass’ elliptic functions. The existence criteria of soliton solutions, by virtue of parameter constraints, are also presented.
Schools as inclusive workplaces: understanding the needs of a diverse teaching workforce in Australian schools
Authors: Dwyer Rachael , Jacobs Rachael , Tuxworth Jiao , Qi Jing , Harris Daniel X. , Manathunga Catherine
Published: June 2024

This paper draws together academic and policy literature around the value of a culturally, linguistically and racially diverse (CLRD) teacher workforce in Australia. While Australia’s population is becoming more diverse, the teaching population is significantly less so, with far fewer teachers born overseas and/or speaking a language other than English at home. This paper seeks to address some reasons for this lack of diversity, and the lived experiences of teachers from diverse backgrounds, including the unique contributions CLRD teachers make to their school communities and the challenges they face. We begin by describing how CLRD experiences are understood within the Australian education context, and the contributions made by CLRD teachers to their school communities, the barriers to entry, and the experiences of exclusion and discrimination faced by many CLRD teachers in Australian schools. We conclude by highlighting the critical need to support CLRD teachers, by ensuring that schools are culturally safe and inclusive workplaces for teachers, as a necessary precursor to ensuring the same for students.
The development of a loop-mediated isothermal amplification (LAMP) assay to detect American foulbrood in managed honey bee populations
Authors: Ackerly Danielle , Tran Lily , Beddoe Travis
Published: June 2024

Paenibacilluslarvae (American foulbrood) is a lethal and arguably the most destructive and economically important notifiable bacterial disease that severely impacts brood and colonies of the Apis mellifera (Western honey bee) worldwide. Detection in apiaries requires visual inspection of clinically symptomatic hives, which is unreliable, with laboratory confirmation required for definitive diagnosis. These methods can be costly, time-consuming, and require access to specialised equipment operated by experienced personnel. Disease confirmation is essential for notifiable diseases to mitigate spread and economic damages; therefore, rapid, sensitive, and specific point of care diagnostics are critical to prevent misdiagnosis and further outbreaks. To improve diagnostic turnaround, we developed a highly sensitive and specific novel loop-mediated isothermal amplification (LAMP) assay for the detection of P. larvae (AFB-LAMP), designed to amplify a small region of the DNA gyrase subunit B gene (GyrB) with 100% specificity demonstrated against non-target bacterial species of the honey bee gut microbiome and analytical sensitivity of 5 × 10−7 ng P. larvae with detection times within 20 min. To further reduce diagnostic resources and times, a bead-beating DNA extraction method suitable for field use was optimised which resulted in an AFB-LAMP diagnostic sensitivity and specificity of 97 and 98%, respectively. Thus, this AFB-LAMP is applicable for use in the field allowing for improved disease management of an agriculturally important species.