bluuebunny/crossref_metadata_2025 huggingface dataset:
The Zilch-Zitter Electron
Authors: Fleury Marc J.J.
Published: August 2024

This paper contains a comparative review of existing Zitterbewegung models. It attempts to synthesize them by offering a toy model containing an extra hypothesis of electromagnetic self-oscillation at the Fermi scale (10−15m). Inspired by Bell violation experiments, Zitterbewegung models and hydrodynamic walker studies, we revisit standing waves in quantum mechanics, echoing de Broglie-Bohm pilot wave theories. Starting with the electromagnetic self-oscillation hypothesis at the Fermi scale we propose an emergent and deductive hierarchical electron structure across multiple scales. The model spans Fermi, Compton (10−13m), Bohr (10−11m) and finally de Broglie (>10−10m). At the Fermi scale, the hypothesis is one of "source-free chiral light", known as the "zilch", emerging as a self-oscillating electromagnetic field at the Schwinger limit. This self-interaction of retarded potentials due to real relativistic delays is a generic self-oscillation of Liénard-Wiechert potentials. This primary Fermi oscillation accounts for charge and mass at the Fermi scale. It generates secondary stable "auto-orbits" dynamics at the Compton scale, manifesting as observable spin and other quantum properties of the usual Dirac zitterbewegung models. These zitter models account for known electron characteristics, including mass, charge, spin and g/2 anomalous factors up to 9 digits precision. We explain the de Broglie wavelength through Doppler-shifted Compton-scale standing waves, in the tradition of de Broglie. The framework extends to electron-positron pair production at the Schwinger limit, described as a result of natural light focusing in non-homogeneous media, utilizing René Thom’s catastrophe theory. This offers a new perspective on baryogenesis and matter emergence from electromagnetic fields. We dub this toy model the "sub-standard" model of the electron.
In Vitro Antiviral Activity of Silydianin-Rich Extract from Silybum marianum Seeds Against Four Strains of Enteroviruses: EV71, Coxsackievirus B2, Coxsackievirus A10, and Poliovirus SL-1 and Its Impact on Improving Delayed Gastric Emptying in Mice
Authors: Zaher Houda , Lemrabet Sanae , Koutchala Neri , Bouchaib Bencharki
Published: August 2024

Background/Objectives Gastroparesis, a chronic digestive disorder characterized by delayed gastric emptying, often results from diabetes, post-surgical complications, autoimmune diseases, and neurological disorders. In approximately 50% of cases, the cause is idiopathic gastroparesis (IGD). Recent studies suggest a link between chronic enteroviral infections and persistent gas-trointestinal symptoms, including delayed gastric emptying. This study investigates the effects of a silydianin-rich extract from Silybum marianum seeds on enteroviral infections in vitro and the mitigation of delayed gastric emptying in mice. Silydianin, a key bioactive compound known for its liver-protective and antioxidant properties, has not been extensively studied for its impact on enteroviral infections and gastroparesis; Methods NMR spectroscopy (¹H, ¹³C, and DEPT) identi-fied silydianin as the primary compound, with minor flavonolignans and trace amounts of an oxidation product. The study assessed the cytotoxicity and antiviral activity of the extract at various stages of the viral life cycle, including virucidal activity, cell protection, and post-infection effects, using neutral red assays in RD cells, with results confirmed by real-time PCR. The viruses studied included Coxsackievirus B2, Coxsackievirus A10, Poliovirus SL-1, and Enterovirus EV71. The impact on delayed gastric emptying was evaluated in a mouse model of gastroparesis using doses of 100 and 200 mg/kg compared to a control; Results: The silydianin-rich extract exhibited con-sistent antiviral activity, with the highest selectivity index (SI) for EV71 (4.08) during virucidal activity. It provided moderate cell protection, with EC50 values ranging from 120.88 to 186.10 µg/mL and SI values from 2.20 to 3.39. Post-infection treatment showed varying efficacy, with Coxsackie A10 demonstrating the highest SI (3.90). In vivo, the extract at 200 mg/kg significantly improved gastric emptying to 96.47% and slightly increased gastrointestinal transit from 50.33% to 61.46%; Conclusions These results suggest that silydianin may be effective in treating enteroviral infections and enhancing intestinal function, making it a promising candidate for gastroparesis treatment and warranting further research.
Performance Evaluation of RTK-GNSS with Survey-Grade Receivers and Short Observation Times in Forested Areas
Authors: Cățeanu Mihnea , Moroianu Maria Alexandra
Published: August 2024

Real-Time Kinematic (RTK) is currently the most widely used method for positioning using Global Navigation Satellite Systems (GNSS) due to its accuracy, efficiency and ease of use. In forestry, position is a critical factor for numerous applications, with GNSS nowadays the preferred solution for obtaining such data. However, the decreased performance of GNSS observations in challenging environments, such as under the forest canopy, must be considered. This paper analyzes the performance of a survey-grade GNSS receiver under coniferous/deciduous tree cover, with short observation times of 30 seconds and corrections received in the field from a Continuously Operating Reference Station (CORS) of the national RTK network in Romania. 84 test points were determined, randomly distributed under the canopy, with reference data collected by topographical surveys using total station equipment. Relatively good accuracies were obtained, especially for horizontal position (RMSEs of 1.47 – 2.07 meters). The variation of GNSS performance under the different forest compositions was found to be statistically significant, while GNSS-specific factors such as DOP values only influenced the precision and not the accuracy of observations. We established that this methodology offers sufficient accuracy, application-dependent, even if the majority of GNSS solutions were code-based, rather than carrier phase-based, due to strong interference from the vegetation.
Analysis of Adipose Tissue Characteristics and Lipid Metabolism in Natural Grazing Mongolian Cattle
Authors: Yu Xueting , Chen Lu , He Xige , Han Yunfei , Huang Yajuan , Wu Jindi , Sha Rina , Borjigin Gerelt
Published: August 2024

The color of carcass fat is an important factor in meat quality. To investigate the characteristics and changes in lipid metabolism of SAT in Mongolian cattle at 34 M of age compared with the control group, we evaluated the color, relative expression of genes associated with browning, and profiles of lipid metabolites by using qPCR and non-targeted lipidomics techniques. Overall, the yellowness value and relative expression of mitochondrial biogenesis–specific markers, thermogenic, UCP2, and beige adipocyte marker genes in the SAT of 34 M cattle were higher than those control (p < 0.05). Using multivariate analysis, 172 significantly different lipids (SDLs) were identified. Triacylglycerols (TGs) and phosphatidylcholines (PCs) had high relative contents with abundant unsaturated fatty acids. The upregulation of TGs observed in the SAT of 34 M cattle mainly consisted of medium- and long-chain fatty acids. Pathway analysis demonstrated that 172 SDLs were primarily involved in glycerophospholipid, glycerolipid, ether lipid, and sphingolipid metabolism. In summary, yellow fat of naturally grazed cattle was impacted by many factors such as lipid metabolism, browning genes expression and age. These findings provide new insight into the characteristics and metabolic pathways of adipose tissue in natural grazing Mongolian cattle.
MFGFF-BiLSTM-EGP: A Chinese Nested Named Entity Recognition Model for Chicken Disease Based on Multiple Fine-Grained Feature Fusion and Efficient Global Pointer
Authors: Wang Xiajun , Peng Cheng , Li Qifeng , Yu Qinyang , Lin Liqun , Li Pingping , Gao Ronghua , Wu Wenbiao , Jiang Ruixiang , Yu Ligen , Ding Luyu , Zhu Lei
Published: August 2024

Extracting entities from large volumes of chicken epidemic texts is crucial for knowledge sharing, integration, and application. However, Named Entity Recognition (NER) encounters significant challenges in this domain, particularly due to the prevalence of nested entities and domain-specific named entities, coupled with a scarcity of labeled data. To address these challenges, we compiled a corpus from 50 books on chicken diseases, covering 28 different disease types. Utilizing this corpus, we developed a nested NER model, MFGFF-BiLSTM-EGP. This model integrates the Multiple Fine-Grained Feature Fusion (MFGFF) module with a BiLSTM neural network and employs an Efficient Global Pointer (EGP) for predicts the entity location encoding. In MFGFF module we designed three encoders, character encoder, word encoder and sentence encoder, this design effectively captures fine-grained features and improves the recognition accuracy of nested entities. Experimental results show that the model performs robustly, with F1 scores of 91.98%, 73.32%, and 82.54% on the CDNER, CMeEE V2, and CLUENER datasets, respectively, outperforming other commonly used NER models. Specifically, on the CDNER dataset, the model achieved an F1 score of 79.68% for nested entity recognition. This research not only advances the development of knowledge graph and intelligent question-answering system for chicken diseases but also provides a viable solution for extracting disease information that can be applied to other livestock species.
Long-Term Breast Morphological Analysis after Ergonomic FALD Flap Reconstruction
Authors: D'Orsi Gennaro , Farcomeni Alessio , Giacalone Martina , Gagliano Elettra , Vannucchi Lisa , Vanni Gianluca , Buonomo Oreste Claudio , Cervelli Valerio , Longo Benedetto
Published: August 2024

Background: The Fat-Augmented Latissimus Dorsi (FALD) flap is an autologous flap that combines Latissimus Dorsi (LD) flap with immediate autologous fat transfer (AFT) in order to improve breast reconstruction (BR) volume. In recent years, our team has described the ergonomic FALD flap, an evolution of this technique which helps to achieve a complete BR in a single surgical step. In this long-term study, we analyze morphological variations of the breast after ergonomic FALD flap reconstruction compared to the traditional transverse FALD flap technique. Methods: Between December 2020 and September 2022 we prospectively enroll patients undergoing BR using FALD flap into 2 groups: Group A included ergonomic FALD flap, while Group B included traditional FALD flap. The primary endpoint of the study was to compare the two groups in terms of breast projection (BP), breast width (BW) and breast height (BH), while the second endpoint concerned the analysis of the aesthetic outcomes. Results: 32 FALD flaps (23 patients) were performed for the Group-A and 31 FALD flaps (25 patients) for Group-B. There were no significant differences regarding demographic variables. After propensity score weighting analysis, Group-A showed a statistically significant better breast projection (p<0.0001) compared to Group-B. (6.05 vs 5.60). Final aesthetic analyses showed to be superior in Group-A concerning breast shape (p=0.001) and global score evaluation (p=0.004). Conclusion: The ergonomic FALD flap offers better long-term aesthetic outcomes for autologous BR with higher breast projection compared to the traditional transverse FALD flap.
Solving NP-Complete Problems Efficiently
Authors: Vega Frank
Published: August 2024

The P versus NP problem is a fundamental question in computer science. It asks whether problems whose solutions can be quickly verified can also be quickly solved. Here, "quickly" refers to computational time that grows proportionally to the size of the input (polynomial time). While the problem's roots trace back to a 1955 letter from John Nash, its formalization is attributed to Stephen Cook and Leonid Levin. Despite extensive research, a definitive answer remains elusive. Closely tied to this is the concept of NP-completeness. If a single NP-complete problem could be solved efficiently, it would imply that all problems in NP can be solved efficiently, proving that P equals NP. This work posits that ONE-IN-THREE 3SAT, a notoriously difficult NP-complete problem, can be solved efficiently, thereby establishing the equivalence of P and NP.
Potential of Wheat Straw for Biogas Production by Anaerobic Digestion in South Africa: A Review
Authors: Kamusoko Reckson , Mukumba Patrick
Published: August 2024

Wheat straw (WS) is a promising substrate for biogas production by anaerobic digestion (AD) due to its high carbohydrate content. An estimated 0.603 million t yr-1 of WS are generated from wheat production systems in South Africa. This is equivalent to an energy potential of 11 PJ. Despite, WS is still undervalued as a bioenergy resource in South Africa due to its structural complexity and low nitrogen content. WS disposal methods, such as use in livestock bedding, burning and burying into the soil, inter alia, are not sustainable and may contribute to global warming and climate change. Commercialization of the AD of WS needs to be further developed and promoted. Pre-treatment (i.e. physical, chemical, biological and hybrid methods) and anaerobic co-digestion (AcoD) are novel strategies that can support the conversion of WS into biogas and other value-added products. Current and future research should focus on optimizing pre-treatment and AcoD conditions towards industrialization of WS into valuable products. This paper focuses on the potential use of WS for biogas production by AD in South Africa. The aim is to create information that will promote research and development, and encourage policy makers and stakeholder participation and investment in WS biogas technology.
Impact of First- and Second-Generation Tyrosine Kinase Inhibitors on the Development of Graft-Versus-Host Disease in Individuals with Chronic Myeloid Leukemia: A Retrospective Analysis on behalf of the Polish Adult Leukaemia Group
Authors: Giordano Ugo , Piekarska Agnieszka , Prejzner Witold , Gil Lidia , Zaucha Jan Maciej , Kujawska Joanna , Dybko Zuzanna , Dudek Krzysztof , Giebel Sebastian , Dybko Jarosław
Published: August 2024

Background: The implementation of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) has brought a significant improvement in the prognosis for CML patients and a decrease in the number of patients requiring allogeneic hematopoietic stem cell transplantation (allo-HCT). Nevertheless, the impact of TKIs on allo-HCT outcomes have not been thoroughly explored. Objectives: The main endpoint of our research was to assess the impact of prior TKI treatment on acute graft-versus-host disease (aGvHD) and chronic graft-versus-host disease (cGvHD). Methods: In our retrospective analysis we included 240 patients treated between 1993 and 2013, and divided them into 3 groups according to the therapy administered prior to matched related or matched unrelated donor allo-HCT (imatinib group n=41, dasatinib/nilotinib group n=28, TKI naïve group n=171). Results: Both the cumulative incidence of aGvHD (p=0.044) and cGvHD (p<0.001) in individuals receiving second generation TKIs (2G-TKIs) prior to allo-HCT compared to patients receiving no TKIs or imatinib (IMA) (40.7% vs 61.4% vs 70.7%, p=0.044; 25.0% vs 76.4% vs 51.2%, p<0.001, respectively). In case of the 2G-TKI cohort, the number of low-grade aGvHD and cGvHD was significantly lower compared to the IMA and TKI-naïve groups (p=0.018, p=0.004; p<0.001 versus TKI-naïve, respectively). In terms of 3-year overall survival (OS) there were no important variations between TKI-naïve, IMA and 2G-TKI (55% vs 49.9% vs 69.6%, p=0.740). Conclusions: The results of our study suggest that TKI treatment prior to allo-HCT may have protective impact on immune-mediated outcomes.
ZNF671 Silencing Affects Signalling Pathways in Head and Neck Cancer via Activation of Oncogenic Non-Coding RNAs
Authors: Zubair Rufai Umar , Smith Kendra , Smith Richard V , Augustine Stelby , Schlecht Nicolas , Ow Thomas , Prystowsky Michael B , Belbin Thomas James
Published: August 2024

Novel ZNF proteins such as ZNF671 that are located on chromosome 19q13 are known to be hypermethylated at a high frequency in HNSCC as well as in other epithelial solid tumors. Their function is largely unknown. Here, we show that ZNF671 is epigenetically silenced in HNSCC primary tumors compared to matched adjacent normal tissue. Moreover, low expression of ZNF671 is significantly associated with decreased survival in HNSCC patients. Over-expression of ZNF671 in UM-SCC-1 oral cancer cells resulted in a significant reduction in tumor cell mobility and invasion compared to the empty-vector control cells. Transcriptomic analysis showed that ZNF671 re-expression resulted in a significant decrease in the expression of a major oncogenic long non-coding RNA LINC00665. Together, these results suggest that epigenetic silencing of ZNF671 may activate multiple oncogenic signaling pathways via the resulting up-regulation of LINC00665.
CREATION OF AN INNOVATIVE EDUCATIONAL ENVIRONMENT IN INSTITUTIONS OF HIGHER EDUCATION - A PEDAGOGICAL CONDITION FOR THE FORMATION OF THE PROFESSIONAL COMPETENCE OF FUTURE BACHELORS OF CHEMICAL AND TECHNOLOGICAL TRAINING
Authors: Kurbanova Halida
Published: August 2024

The article substantiates the opinion regarding the creation of an innovative educational environment in institutions of higher education as one of the pedagogical conditions for the formation of professional competence of future bachelors of chemical and technological training; the views of scientists on the training of specialists of new quality are revealed; definitions of such concepts as “innovative education”, “pedagogical innovations” are given; the technological component of the formation of an innovative educational environment at the ZVO, the main tasks of the scientific and innovative activity of the university are given; the application of innovative technologies in the educational process and the forms and methods of their implementation are considered; the application of modern technologies (“case technologies”, M-Learning - technologies, TV- technologies, Internet - technologies) and the introduction of training methods in professional training and increasing the professional competence of future bachelors of chemical and technological training, which contribute to the assimilation of knowledge, are proposed, development of skills and formation of professional competence (special software tools, web servers and innovative teaching methods (e-learning, use of Internet resources, problem-based learning, case method, interactive presentations, mind mapping); the effectiveness of the given pedagogical conditions has been proven.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 17.08.2024 г. по 23.08.2024 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: August 2024

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19 за неделю с 17.08.2024 г. по 23.08.2024 г.
Missed Medial Clavicular Physeal Fracture-Posterior Dislocation Complicated by Brachiocephalic Pseudoaneurysm
Authors: Walia Palak , Fredette Ryan , Mortimer Errol
Published: August 2024

Case:

We present a 17-year-old male patient with an initially missed posterior sternoclavicular fracture dislocation who presented with symptoms related to thrombotic emboli arising from a pseudoaneurysm. He was treated 6 weeks after injury with a figure-of-eight tendon allograft repair with good clinical outcomes.

Conclusion:

This is a unique presentation that highlights the significant risk of a missed diagnosis, life-threatening complications that may ensue, and biomechanically superior surgical intervention.
Environmental Study in Assessing the Water Quality of the Al-Gharraf River for Agricultural Purposes
Authors: Al-Kinani Hasanain Ali
Published: August 2024

General Background: The Al-Gharraf River in Thi Qar Governorate, Iraq, is crucial for agricultural irrigation and livestock sustenance. Specific Background: However, the river's water is suspected of being polluted with physical and chemical contaminants, which may adversely affect soil properties, crop growth, and the health of livestock and poultry in the region. Knowledge Gap: Limited research exists on the extent of pollution in the Al-Gharraf River and its impact on agricultural and livestock practices. Aims: This study aims to assess the pollution levels of the river's water by evaluating key physical and chemical parameters, determining its suitability for agricultural purposes, and understanding the implications for livestock and poultry consumption. Results: The water quality, assessed using the American Salinity Laboratory classification, placed the river in the C3-S2 category, indicating third-degree salinity (very salty) and second-degree sodium (medium). Most physical and chemical measurements exceeded permissible limits for irrigation water, except for pH and Sodium Adsorption Ratio (SAR), which remained within acceptable bounds. The water, while within the premium class for low salt levels, posed significant risks to livestock and poultry due to high salinity and other pollutants. Novelty: The study provides a comprehensive analysis of the river's water quality, highlighting the critical need for regular monitoring and the implementation of modern irrigation practices to prevent further soil salinization. Implications: These findings emphasize the urgency of adopting sustainable water management strategies and raising awareness to prevent harmful discharges into the river, ensuring the long-term viability of agriculture and livestock in the region
Peran Guru Pendidikan Agama Islam dalam Penanaman Nilai Toleransi pada Peserta Didik di SMP Negeri 38 Samarinda
Authors: Asriyanto Muhammad , Janah Fathul , Setiawan Agus
Published: August 2024

Sikap intoleran yang kerap di tunjukkan pada sebagian kelompok ataupu individu baik dilingkungan masyarakat, sekolah maupun media sosial, sudah sepatutnya menjadi perhatian bagi semua kalangan, khususnya guru pendidikan agama islam yang memiliki peran bukan hanya untuk meningkatkan ritual keagaaman peserta didiknya melainkan berperan dalam mengajarkan bagaiman mengharagai perbedaan yang ada dalam mewujudkan kerukunan antar umat beragama. Oleh karena itu penelitian ini bertujuan untuk mengetahui peran guru pendidikan agama islam dalam penanaman nilai toleransi pada peserta didik di SMP Negeri 38 Samarinda. Jenis penelitian yang digunakan dalam penelitian ini adalah jenis penelitian kualitatif dengan pendekatan fenomenologi. Pengumpulan data menggunakan teknik wawncara, observasi dan dokumentasi. Teknik analisis data dilakukan dengan menggunakan kondensasi data, penyajian data dan penarikan kesimpulan, uji keabsahan data menggunakan triangulasi teknik dan sumber. Hasil penelitaian yang didapatkan, peran guru PAI guru sebagai fasilitator menyediakan fsilitas pembelajaran, peran sebagai pembimbing mengarahkan siswa dalam kegiatan keagaman, peran sebagai motivator dengan memberikan dorongan dalam bersikap toleran dan peran sebagai evaluator melaukan penilaian dan perbaikan.
Implementasi Penanaman Karakter Nilai Pancasila dalam Mencegah Lost Generation di SMAN 14 Kota Samarinda
Authors: Gunawan Sandri , Ilyasin Mukhamad , Julaiha Siti
Published: August 2024

Implementasi Penanaman karakter penanaman karakter nilai pancasila yaitu, nilai religius, nilai nasionalisme, nilai integritas, nilai kemandirian dan nilai gotong royong. Oleh sebab itu penelitian itu bertujuan untuk mendeskripsikan Nilai-nilai karakter pancasila, implementasi penanaman karakter pancasila. Penelitian ini berjenis kualitatif dengan pendekatan study fenomologi. Subjek yang dipilih dalam penelitian ini dibatasi dalam lingkup Kepala Sekolah, Waka Kurikulum dan guru-guru SMA Negeri 14 Kota Samarinda. Untuk mendapatkan data secara menyeluruh penelitii menggunakan tekhnik observasi, dokumentasi dan wawancara. sedangkan tehnik analisis data peneliti mengggunakan dalam tiga tahapan yaitu kondensasi data, penyajian data, dan penarikan kesimpulan. Data yang didapatkan akan diuji melalui tehnik ketekunan pengamatan, triangulasi sumber dan triangulasi tehnik. Hasil dari penelitian ini mengungkapkan bahwa di SMAN 14 Samarinda Nilai- nilai Karakter Pancasila yang terlaksana hanya ada tiga yaitu Nilai karakter religius, nilai nasionalisme dan nilai integritas. Implementasi Penanaman Karakter mengamalkan ajaran agama islam, sikap gotong royong dan disiplin. Pengawasan dan Peberian sanksi memberikan sanksi seperti menghapal surah-surah, membersihkan toilet, dan membersihkan halaman sekolah.
Inovasi Pembelajaran Dalam Kurikulum Merdeka dimensi Kreatif
Authors: Wahyuni Tri , Darsinah Darsinah , Wafroturrahmah Wafroturrahmah
Published: August 2024

Pentingnya inovasi pembelajaran dalam Kurikulum Merdeka adalah untuk memastikan bahwa pendidikan dapat mengikuti perkembangan zaman dan kebutuhan siswa di era yang terus berubah. Penelitian ini bertujuan untuk mengetahui inovasi pembelajaran dalam kurikulum merdeka. Penelitian ini menggunakan metode kualitatif. pendekatan penelitian yang digunakan untuk memahami dan menjelaskan fenomena kompleks dalam konteks yang lebih luas. Metode ini berfokus pada interpretasi makna subjektif yang terkandung dalam data yang dikumpulkan, dengan tujuan untuk menggali pemahaman yang mendalam tentang pengalaman, persepsi, keyakinan, dan konteks sosial yang melatarbelakangi fenomena tersebut. Tempat penelitian ini dilakukan di SMK Al-Islam Surakarta. Inovasi pembelajaran yang diterapkan di SMK Al-Islam Surakarta dengan memanfaatkan powerpoint sebagai media pembelajaran. Penayangan video menjadi opsi lain dalam penyampian materi. Penyampaian materi melalui video memiliki keunggulan dalam membentuk kreativitas siswa. Pemnafaatan aplikasi Canva menjai salah satu inovasi dalam pembelajaran yang bisa diterapan dalam kelas. Penggunaan aplikasi Canva dapat menjadi alat yang efektif untuk membentuk kreativitas siswa
Efektivitas Kepemimpinan Kepala Bidang Pendidikan Madrasah Dalam Meningkatkan Kinerja Pegawai Di Kalimantan Timur
Authors: Ananiah Ananiah , Rufida Rina , Rahmatillah Rahmatillah
Published: August 2024

Artikel ini mengkaji tentang seberapa efektif kepemimpinan kepala bidang pendidikan madrasah dalam meningkatkan kinerja pegawai di Kantor Wilayah Kementerian Agama Provinsi Kalimantan Timur. Jenis penelitian ini adalah penelitian kuantitatif. Teknik pengumpulan data yang digunakan yaitu observasi, angket dan dokumentasi. Teknik analisis data menggunakan analisis regresi sederhana. Hasil penelitian menunjukkan terdapat Nilai thitung 5.890 dan ttabel 2.109, dengan demikian thitung > ttabel yang mengakibatkan ditolaknya Ho dan diterimanya Ha yang berati kepemimpinan kepala bidang pendidian madrasah berpengaruh secara signifikan terhadap kinerja pegawai di Kantor Wilayah Kementerian Agama Provinsi Kalimantan Timur. Berdasarkan hasil uji koefisien determinasi diperoleh nilai korelasi/hubungan (R) adalah 0,214. Sedangkan nilai R square sebesar 0,246. Hal ini menunjukan bahwa 24,6 % variabel kepemimpinan berpengaruh terhadap peningkatan kinerja pegawai.
The Effect Ease Of Use And Perceived Risk On Purchasing Decisions On Marketplace Shopee
Authors: Wicaksono Dimas Setiawan , Ruhamak Muhammad Dian , Yap Nonni
Published: August 2024

The purpose of this study is to determine the effect ease of use and Perceived risk on purchasing decisions on marketplace shopee in kediri city. This research is of the explanatory research type with a quantitative approach. The population of the study consists of Shopee marketplace users in Kediri city, and the exact population size is unknown. The sampling technique used in this study is non-probability sampling with purposive sampling technique. The sample size in this study is 100 respondents, determined using the Lemeshow formula. Data analysis is conducted using multiple linear regression or descriptive statistics. Data processing in this study is performed using SPSS version 23. The results of this study show that:  (1) Ease of use has a partial significant positive effect on purchasing decisionss with a significance value of 0.000 0.05. (2) Perceived risk also has a partial significant negative effect on purchasing decisionss with a significance value of 0.002 0.05. (3) Simultaneously, ease of use and Perceived risk have a significant influence on purchasing decisionss, with a calculated F count of 19.831 the F table value of 2.69, and the obtained significance value is 0.00 α 0.05.
PEMANFAATAN ROBOTIC PROCESS AUTOMATION DALAM PEMBUATAN LAPORAN PENINDAKAN KEJADIAN BENCANA SECARA OTOMATIS
Authors: Sujadi Harun , Susandi Dony , Martin Kurnia
Published: August 2024

Badan penanggulangan bencana daerah (BPBD) adalah lembaga non-departemen pemerintah yang bertanggung jawab atas pengendalian bencana di provinsi, kabupaten, dan kota. Salah satu tugasnya adalah melaksanakan dan membuat laporan kejadian bencana berdasarkan hasil kaji situasi dan persyaratan cepat di lokasi bencana selama tahap tanggap darurat. Karena semua proses dilakukan secara konvensional saat membuat laporan bencana, staf unit data informasi sering mengalami kesulitan dalam mengolah dan memeriksa laporan. Untuk mempercepat proses tersebut, aplikasi berbasis web dan robotic process automation (RPA) yang terintegrasi dapat membantu. robotic process automation (RPA) dapat mengotomasi proses yang dilakukan oleh operator komputer, seperti mengambil data, menginput data, memeriksa laporan, dan mengirim laporan. Berdasarkan hasil pengujian, proses yang dilakukan oleh robotic process automation (RPA) untuk menginput form surat pengantar laporan memiliki waktu eksekusi yang dua kali lebih cepat dari proses konvensional yang dilakukan oleh manusia. Sementara robotic process automation (RPA) untuk memeriksa dan mengirimkan laporan lebih difungsikan untuk melakukan proses pemeriksaan masuknya laporan secara berkala.
Differences in Active Ingredients of White Chicory Leaves (Brassica pekinensis L) as a Bio-Larvicidal Against Aedes aegypti larvae
Authors:   Poltekkes Kemenkes Surabaya, Marlik Marlik , Okta Dhea Stya , Ngadino Ngadino , Nurmayanti Demes , Sulistio Irwan
Published: August 2024

Continuous chemical dengue control can cause vector resistance and environmental pollution. Developing natural larvicides (bio-larvicides) from plant toxins like white chicory, which can poison Aedes aegypti larvae, is necessary for a sustainable alternative. This study aimed to analyze differences in active ingredients in white chicory leaves (Brassica pekinensis L) as bio-larvicide against Aedes aegypti larvae. This study was a pure experiment using a post-test-only control design using 1,225 Aedes aegypti instar III larvae with extracts of alkaloid active ingredients, flavonoids, and concentrations of 0%, 24%, 34%, and 40% with 3 times replication. Data were analyzed using a probit test, one-way ANOVA, and Post Hoc LSD. The results showed the potential of active ingredients in white chicory leaves against the death of Aedes aegypti larvae (p-value = 0.000). The average percentage of larval mortality concentration was 24%, 34%, 40%, in alkaloids was 41%, 60%, 66%, and in flavonoids was 45%, 64%, 68%. The active ingredient of white chicory leaves can kill Aedes aegypti larvae with LC50 in 29% alkaloids and 27% flavonoids.
Variation and Predictors of COVID-19 Mortality in Hospitalized Cases in West Sumatra Province, Indonesia: A Retrospective Observational Study
Authors:   Universitas Andalas, Padang, Djafri Defriman , Suzana Eka Putri Ade ,   Universitas Andalas, Padang, Pradipta Yudi ,   Universitas Andalas, Padang
Published: August 2024

During 2020, the year of the COVID-19 pandemic, different Indonesian provinces had different numbers of COVID-19 infections and fatalities, particularly in West Sumatra Province. This study aimed to investigate the variation of confirmed COVID-19 cases and determine predictors of mortality in hospitalized patients across districts in West Sumatra Province. A retrospective observational study was conducted during the COVID-19 pandemic. From March 2020 to June 2021, 46,005 confirmed cases were collected in the province, of which 42,308 were hospitalized and analyzed. Confirmed cases and deaths were compared by geographic location using spatial analysis. The risk predictors of death were estimated using logistic regression. COVID-19 incidence and mortality varied across cities/districts, with less than 1,000 confirmed cases appearing to be the lowest number. A distinct pattern was visible nonetheless when the incidence density of confirmed cases and deaths was higher. Acute respiratory distress syndrome during the COVID-19 treatment had a higher risk of death (OR = 75.2, 95% CI: 25.6–250). The most significant predictors of death in terms of comorbidity were pneumonia, followed by cancer, chronic obstructive pulmonary disease, diabetes, cardiac disease, and hypertension.
Prevención del embarazo en adolescentes
Authors: Hubert Celia , De la Vara-Salazar Elvia , Villalobos Aremis , Suárez-López Leticia , Muradás-Troitiño Maria de la Cruz , Mejía-Paillés Gabriela , Barrientos-Gutiérrez Tonatiuh
Published: August 2024

Objetivo. Analizar la evolución de los indicadores de salud sexual y reproductiva de la Estrategia Nacional para la Prevención del Embarazo en Adolescentes (Enapea) en 2018-19 y 2021-23, contrastando los avances con respecto a las metas a 2030. Material y métodos. Se utilizaron las Encuestas Nacionales de Salud y Nutrición (Ensanut) 2018-19 (n=14 117) y 2021-23 (n=7 505) para estimar 11 indicadores de la Enapea. Mediante pruebas de diferencias de proporciones, se analizaron los avances, retrocesos o estancamiento de los indicadores entre 2018-19 y 2021-23. Resultados. De los 11 indicadores examinados, mejoraron tres relacionados con embarazo y conocimiento del condón, y empeoraron dos sobre uso consistente de anticoncepción moderna y en la última relación sexual. Conclusiones. Considerando que el Covid-19 pudo haber frenado los avances de la Enapea, es relevante continuar fortaleciendo la educación integral en sexualidad, además de capacitar y sensibilizar al personal de salud e incrementar la cobertura y provisión de los servicios amigables para adolescentes.
Inseguridad alimentaria y del agua
Authors: Mundo-Rosas Verónica , Shamah-Levy Teresa , Muñoz-Espinosa Alicia , Hernández-Palafox Corin , Vizuet-Vega Norma Isela , Torres-Valencia María de los Ángeles , Figueroa-Oropeza José Luis , Gutiérrez-Atristain Alejandra , Bautista-Arredondo Sergio , Téllez-Rojo Martha M , Lewise-Young Sera , Melgar-Quiñonez Hugo , Pérez-Escamilla Rafael , Gaitán-Rossi Pablo , Unar-Munguía Mishel , García Olga P , Del Castillo-Matamoros Sara Eloísa , Dolores-Maldonado Gandy Kerlin , Gallardo-Medina Delmy del Carmen , Díaz-Trejo Lizbeth , Del Monte-Vega Marti Yareli , López-Ridaura Ruy
Published: August 2024

Objetivo. Analizar la inseguridad del agua (IAg), frecuencia del suministro de agua (FSA) e inseguridad alimentaria (IA) en hogares mexicanos, abordando sus determinantes sociales y aportar recomendaciones para las políticas públicas. Material y métodos. Se analizó la información de 28 500 hogares de la Encuesta Nacional de Salud y Nutrición (Ensanut Continua 2020-2023). Se aplicaron escalas de experiencias validadas como HWISE y ELCSA, para medir la IAg e IA, así como un indicador sobre FSA, de acuerdo con algunos determinantes. Resultados. 16% de los hogares mexicanos experimentan IAg y 22% padecen IA moderada y severa. Sólo 34.7% recibe agua las 24 horas todos los días. Los determinantes de los hogares más afectados por la IAg, IA y en FSA son las peores condiciones de bienestar, ser indígena y cuando la IA e IAg se encuentran juntas en los hogares. Conclusiones. Es imprescindible acelerar la aplicación y mejorar la cobertura de acciones que impacten positivamente en el acceso y disponibilidad de agua y alimentos de las personas vulnerables.
Lactancia materna
Authors: González-Castell Luz Dinorah , Unar-Munguía Mishel , Bonvecchio-Arenas Anabelle , Rivera-Pasquel Marta , Lozada-Tequeanes Ana Lilia , Ramírez-Silva Claudia Ivonne , Álvarez-Peña Ivonne Jasmín , Cobo-Armijo Fernanda , Rivera-Dommarco Juan
Published: August 2024

Objetivo. Estimar las brechas en lactancia materna (LM) en México para alcanzar las metas del objetivo global de nutrición sobre LM al 2030 (OGN 2030) y emitir recomendaciones de política pública. Material y métodos. Se utilizó información de mujeres (12-59 años) y sus hijos/as <24 meses de la Encuesta Nacional de Salud y Nutrición (Ensanut) 2021 a 2023 para la estimación de indicadores de LM de acuerdo con variables sociodemográficas. Se estimaron las brechas en LM para alcanzar las metas del OGN 2030 vs. las tendencias nacionales, considerando la efectividad de intervenciones en contextos similares a México. Resultados. La prevalencia de lactancia materna exclusiva (LME) en niños/as <6 meses es de 34.2%, mientras que la de LM continuada a los dos años es de 43%; éstas son más bajas entre mujeres con menor paridad y con empleo remunerado y más altas entre mujeres que recibieron información sobre LM en el embarazo o consulta. Se estima alcanzar 42.5% de LME para 2030 con la tendencia actual, no obstante, la meta OGN 2030 de 70% sólo se logrará si se capacita al personal de salud y comunitario en consejería en LM, se fortalece la Iniciativa Hospital Amigo del Niño y la Niña, hay cumplimiento del Código Internacional
de Comercialización de Sucedáneos de la Leche Materna y si se extiende la licencia de maternidad pagada en México. Conclusiones. Se requiere un fuerte compromiso para implementar políticas y acciones integrales en distintos sectores que permitan alcanzar las metas de LM del OGN 2030 en México.
Life History, Incidence and Damage symptoms of the Red Pierrot butterfly, Talicada nyseus (Guerin) (Lepidoptera: Lycaenidae) on Bryophyllum pinnatum (Lam.) Oken
Authors: Kallekkattil Soumya
Published: August 2024

Laboratory studies were conducted on the development of immature stages, life history and behavior of the Red Pierrot butterfly, Talicada nyseus (Guerin) (Lepidoptera: Lycaenidae) reared on Bryophyllum pinnatum (Lam.) Oken. Fabaceous and succulent plants in Brazil, China, India, Africa, and all tropical countries can be infested by larvae of T. nyseus. The pest had four larval instars and completed its life cycle in 36.95 ± 3.31 days. The mean incubation period of the egg was 3.75 days. The prepupal, pupal, and larval stages' respective mean development times were 1.51 ± 0.50, 8.56 ± 10.65, and 14.23 ± 1.82, days. The length of the larva in its first and last instars was 1.95 ± 0.13 and 15.85 ± 0.93, respectively. In larval stages, there was no apparent relationship between length and width. The sex ratio was 1.39:1 in favor of females. One day following eclosion, adults were prepared for mating. The ovaries of the adult female held 75.1 eggs. Male and female butterflies who were not fed lived only three to five days instead of eleven to fourteen days like those who had access to water. The findings of this study will be helpful in developing Integrated Pest Management tactics to combat this pest.
Computer-assisted chiral HPLC method development for ozanimod on polysaccharide- based chiral stationary phases: possibilities and limitations
Authors: Ferencz Elek , Szabó Zoltán-István , Zöldhegyi Arnold , Dombi Gergely , Molnár Gergely , Dobó Máté , Varga Erzsébet , Molnár Imre , Tóth Gergő
Published: August 2024

In this study, a direct high performance liquid chromatography method was developed to determine the enantiomeric purity of the immunomodulatory drug, ozanimod. A systematic method development process was followed, incorporating risk assessment, identification of critical analytical procedure parameters (APP), initial screening of stationary phases, and software-assisted optimization of method parameters. Eight different polysaccharide-based chiral columns (Lux i-Amylose-1, Lux Amylose-2, Chiralpak AD, Chiralcel OD, Lux Cellulose-1, Lux Cellulose-2, Lux Cellulose-3, and Lux Cellulose-4) were selected to assess chiral separation of enantiomers under polar organic elution mode. The most promising results were obtained using a methanol (MeOH)-2-propanol (IPA) mixture on the Chiralpak AD column. Following this, systematic modeling was conducted using DryLab software to optimize method conditions, including isocratic eluent composition (%IPA in MeOH), temperature, and flow rate. Baseline separation was achieved within fifteen minutes using the optimized parameters: Chiralpak AD column thermostated at 10°C, and a mobile phase of MeOH:IPA:diethylamine (DEA), 70:30:0.1 (v/v/v), delivered at a flow rate of 0.8 mL/min. The developed method was validated according to the International Council on Harmonization guideline Q2(R2) for chiral impurity determination in ozanimod samples. Additionally, in silico robustness testing was conducted to determine tolerance limits for critical separation parameters and their impact on enantioresolution. Our findings demonstrate the utility of DryLab, typically employed for reversed-phase achiral separations, in optimizing chiral methods even in polar organic mode. The software's limitations for this purpose are also discussed.
Quadruple-well ferroelectricity and moderate switching barrier in defective wurtzite α-Al2S3: a first-principles study
Authors: Akamatsu Hirofumi , Shimomura Yuto , Ohno Saneyuki , Hayashi Katsuro
Published: August 2024

Wurtzite-type ferroelectrics are highly promising for next-generation microelectronic devices due to their ferroelectric properties and integration with exiting semiconductors. However, their high coercive fields, which are close to breakdown electric fields, need to be lowered. To deal with this issue and secure device reliability, much effort has been devoted to exploring novel wurtzite compounds with lower polarization switching barriers and implementing doping strategies. Here, we report first-principles calculations on polarization switching in cation-vacancy ordered wurtzite α-Al2S3, unveiling its uniaxial quadruple-well ferroelectricity and moderate switching barrier, 51 meV/cation, which is much lower than that of conventional wurtzite ferroelectrics. There are three important features relevant to the Al vacancies leading to the uncommon quadruple-well ferroelectricity and the moderate switching barrier: mitigation of cation-cation repulsion, structural flexibility that alleviates an in-plane lattice expansion, and formation of s-like bonding states consisting of Al 3pz and S 3pz orbitals. Biaxial compressive strain and Ga doping lower the switching barriers by up to 40%. This study encourages experimental investigation of the ferroelectric properties for defective wurtzite α-Al2S3 as a new promising material with unconventional and intriguing ferroelectricity and suggests a potential strategy for reducing switching barriers in wurtzite ferroelectrics: introducing cation vacancies.
A Studies on PVA/MAA:EA polymer blend films modified by Fe3+ doping
Authors: Gopal N. O , Pravakar Ojha , Basha Md. Hussain , Kumar Y. Madhav
Published: August 2024

Pristine and Fe (1.0, 2.0, 3.0, 4.0 and 5.0 mol%) doped PVA/MAA:EA polymer blend films were prepared by solution casting method and characterized by various techniques. TGA analysis validates the occurrence of three distinct weight loss phases attributed to the removal of volatile substances from both the surface and interior of the material, as well as the decomposition of the polymer. X-ray diffraction (XRD) investigations validate a decrease in crystallinity as the dopant concentration increases. Scanning electron microscope (SEM) micrographs show uniform morphology. Fourier transform infrared (FTIR) spectrum exhibits bands characteristic of stretching and bending vibrations of O–H, C–H, C = C and C–O groups and the changes in the spectrum with dopant concentration show the miscibility of dopant with the polymer blend. The UV-visible spectra demonstrate. that there is A downturn of the optical band gap increases as the concentration of Fe rises and exhibit absorption bands corresponding to the transitions 6A1g→4A1g and 6A1g→4T2g of Fe3+ ions in distorted octahedral symmetry. Electron paramagnetic resonance (EPR) spectra exhibit resonance signal around g = 2.12, attributed to the Fe3+ ions in the distorted octahedral environment and signal around g = 6.8, attributed to the number of spins engaged in the resonance is determined through EPR analysis in an environment exhibiting proximity to rhombic symmetry. The measurement is conducted as a function of dopant concentration and the paramagnetic susceptibility. The conductivity of Fe3+ ions doped PVA/MAA:EA polymer blend films increases with an increase in Fe3+ concentration, which is explained in terms of an increase in the amorphic.
Accelerated Bidirectional Photoinduced Electron Transfer in A Photo-chromic Polyoxoniobate Enabled by Excited Bridge
Authors: Zheng Shou-Tian , Fan Jin-Ai , Yu Hao , Yu Xu-Ying , Yang Wei-Chao , Li Xin-Xiong , Sun Cai
Published: August 2024

The bridge connecting the electron donor and acceptor is crucial for electron transfer, however, the impact of the excited bridge on this process remains unclear. Here, we present a proof-of-concept model using an f-type bridge in an electron transfer photochromic poly-oxoniobate. We discovered that the excited bridge significantly accelerates electron transfer, resulting in a 3.3-fold increase in the col-oring rate. Colored samples exhibit accelerated bleaching when excited by light, marking the first instance of light-assisted acceleration of reverse electron transfer, which was previously constrained by thermal mode. The light-assisted bleaching rate is approximately 494 times faster than the traditional thermal mode at room temperature, leading to a significant reduction in the half-life from 91.58 min to 11.13 s. The study identifies that the primary cause of the increased electron transfer rate is the significant enhancement in electronic coupling between the initial and colored states by the excited bridge. This intriguing photochromic behavior not only opens up new applications for multi-factor anti-counterfeiting but also initiates research into the electron transfer chemistry of excited bridges.
Free and Bioavailable Vitamin D Moderately Predicts Total Vitamin D Status in Tuberculosis Patients and Household contacts
Authors: Acen Ester Lilian , Bwambale Kelvin , Biraro Irene Andia ,   David Patrick Kateete2, Joloba Moses L. , Olum Ronald , Bbuye Mudarshiru , Worodria William
Published: August 2024

Total vitamin D is considered a perfect index for assessment of vitamin D status, attributable to longer half-life. However the bioactive free and bioavailable vitamin D levels are available to the cell. This study aimed to compare and evaluate the accuracy of free and bioavailable vitamin D in defining total vitamin D status in Patients with Tuberculosis. This was a cross-sectional study among newly diagnosed active tuberculosis patients, latent tuberculosis individuals and individuals without TB infection. Total vitamin D was measured by electrochemiluminescence and free and bioavailable vitamin D was measured using ELISA. The diagnostic performance of free and bioavailable portion was 59.18% for sensitivity, 66.67% for specificity, and 63.0% for AUC. The kappa statistic was 1460 (P-value = 0.0759), in the deficient group. In insufficient, sensitivity was,56.9% specificity was 66.7%, and AUC was 61.8%. Kappa was 0.146, P = 0.07. Free and bioavailable vitamin D is a moderate indicator of vitamin D status. The study suggested that free and bioavailable vitamin D is not superior for defining total vitamin D status in TB, however it may be complementary. Further studies are needed to improve the definition of vitamin D status and its importance in immunity.