bluuebunny/crossref_metadata_2025 huggingface dataset:
Salicornia emerici Duval-Jouve and Sarcocornia alpini (Lag.) Rivas Mart. from Southern Tunisia: Potential Sources of Functional Ingredients with Nutritional and Health Promoting Benefits
Authors: Harboub Nesrine , Mighri Hedi , Bennour Naima , Dbara Mohamed , Pereira Catarina , Chouikhi Naima , Custódio Luísa , Abdellaoui Raoudha , Akrout Ahmed
Published: May 2024

Aerial biomass of the edible halophyte species Salicornia emerici Duval-Jouve and Sarcocornia alpini (Lag.) Rivas Mart. (Amaranthaceae), collected from southern Tunisia, were investigated as potential sources of functional ingredients. For that purpose, dried biomass was profiled for proximate and mineral composition, and its hydroethanolic extracts were analyzed for phenolics contents by spectrophotometric and chromatographic (HPLC-ESI-MS) methods. The extracts were then profiled for in vitro antioxidant properties (radical scavenging activity (RSA) of DPPH and ABTS radicals, and ferric reducing power (FRAP)), cytotoxicity, and enzymatic inhibition toward enzymes related with human diseases, namely acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) (Alzheimer´s disease: AD), α-amylase and α-glucosidase (type 2 Diabetes Mellitus: T2DM), and tyrosinase (skin hyperpigmentation disorders). Biomass had relevant levels of minerals, especially sodium, potassium and iron. The extracts were not toxic, contained various bioactive phenolic compounds, such as naringin and quinic acid and exhibited relevant FRAP and inhibition properties against α-glucosidase and tyrosinase. Our findings suggest that there is potential to further explore the biomass from S. alpini and S. emerici as safe and sustainable sources of nutrients and of natural products with antioxidant, anti-diabetic and anti-tyrosinase properties, which might yield significant economic benefits for the southeastern region of Tunisia.
A method to qualify image post-processing for thin wall thickness prediction from NIR camera image of aluminum WAAM process
Authors: Béraud Nicolas , Lombard Axel , Dellarre Anthony , Vignat Frédéric , Villeneuve François
Published: May 2024

Wire Arc Additive Manufacturing (WAAM) is a metal arc welding additive process that allows the production of large parts. Managing the quality of produced parts is a key challenge to the adoption of this technology in the industry. A particular case of this is the production of aluminum thin walls and the management of their thicknesses. Literature supports that the use of a near-infrared camera is a good way to monitor the meltpool shape to predict the manufactured thickness. Nevertheless, the post-processing applied to the image has a big influence on the accuracy of the measure. That is why, this article proposes a method to qualify image post-processing for thin wall thickness prediction from near-infrared camera images of aluminum WAAM process. A dataset from the literature is used to evaluate the accuracy of different post-processes. First, a method is proposed to evaluate the accuracy of a given post-process. Secondly, two types of post-processing are presented: post-processing based on conventional image processing and post-processing based on neural networks. Their accuracy is evaluated with the proposed method. The article concludes that the proposed method is adapted to qualify post-processes and that the proposed post-processing based on neural networks gives significant results in terms of accuracy.
Manganese with Salicylic Acid Optimize the Growth Dynamics and Quality Potential in Indian Mustard (Brassica juncea L.)
Authors: Guin Aritra , Korav Santosh , A Rajanna G. , Elansary Hosam O.
Published: May 2024

As an oilseed crop, mustard—a plant in the family Brassicaceae—is essential in India and worldwide. Crucial to plant metabolism are manganese and salicylic acid. We performed a field experiment to determine how they affected Indian mustard (Brassica juncea). Using a Randomized Block Design with three replications, the experiment included ten treatment combinations. These included control groups, different doses of sole salicylic acid (75, 150, 300 ppm), sole manganese (0.25, 0.5, 0.75 mM MnSO4), and combinations of the two. According to the experimental results, increasing dosages of both manganese and salicylic acid reversed the effects of sole foliar application by increasing the mustard growth and biochemical properties. It is worth mentioning that the addition of 0.5 mM manganese and 150 ppm salicylic acid externally increased stem dry weight by 1.24-fold, total chlorophyll content by 2.35-fold, relative water content by 1.25-fold, grain protein content by 1.11-fold, and oil content by 1.19-fold. To top it all off, the leaf membrane injury index went down by 36.2–53.2% after the combined application. The combination of salicylic acid and manganese yielded superior outcomes in optimizing growth dynamics and quality potential compared to individual applications of either compound.
Trends in the burden of pancreatic cancer due to high fasting plasma glucose in China, 1990-2019, and projections until 2029
Authors: Zhao Li-jun , Fan Hua , Yu Qing-wen , Tang Ting , Zhang Sheng-hui , You Yao , Wang Mingwei , Cheng Yong-ran , Lu Kang
Published: May 2024

Aim: This study aimed to analyze the burden of high fasting plasma glucose (HFPG)-induced pancreatic cancer deaths in China, to compare the long-term trend of mortality from this condition in China during 1990–2019, and to predict the trend for the next 10 years.
Methods: Data from the Global Burden of Disease Study 2019 were used for this research. The burden of pancreatic cancer in China between 1990 and 2019 due to HFPG was investigated, and the burden was stratified by sex and age. The age–period–cohort analysis was used to determine the contributions of age, period, and cohort effects of HFPG on pancreatic cancer. The mortality from the disease during 2020–2039 was projected using the Bayesian age–period–cohort (BAPC) model.
Results: From 1990 to 2019, HFPG led to a significant increase in the number of deaths from pancreatic cancer and the mortality rate in China. The age-standardized mortality rate of pancreatic cancer attributable to high fasting plasma glucose per 100,000 individuals in China increased from 0.199 in 1990 to 0.413 in 2019 (average annual percentage change of 2.53 [95% confidence interval, 2.19–2.86]).The number of deaths and mortality rates were consistently higher in men than in women. Mortality rates varied with age, with the highest number of deaths occurring in people aged 70–74 years and the highest mortality rate at 85 years of age. The BAPC method was used to predict the mortality rate of pancreatic cancer up to 2029, which revealed that both demonstrated a trend of slow growth, with women showing a decreasing trend and men showing an increasing trend.
Conclusion: The results of this study provide strong evidence that the number of deaths and mortality rate from pancreatic cancer due to HFPG have shown a clear upward trend in China over the past 30 years. This observation highlights the need to urgently solve the issues in the treatment of pancreatic cancer. Furthermore, lifestyle intervention policies should be implemented in China to effectively control pancreatic cancer mortality.
We cannot keep doing what we have always done and expect that things will be different: A scoping review of the lifestyle drift concept
Authors: Halsall Tanya , Orpana Heather , Jan Misha
Published: May 2024

Background
Lifestyle drift is a phenomenon wherein the focus of interventions aimed at improving health and decreasing health inequities that start with the intention of acting on upstream social determinants of health inadvertently drift downstream towards interventions targeting individual health behaviours. While lifestyle drift has been referred to in a growing body of literature, as far as we are aware, there is not currently any scoping or systematic reviews that examines the concept of lifestyle drift. The objective of this scoping review is to summarize the existing literature on lifestyle drift, describe how it is defined in the literature, the causes or mechanisms of influence that lead to lifestyle drift and ways to address it.
Methods
A comprehensive search strategy was developed with guidance from a librarian and seven databases were searched. Title and abstract and full text screening was conducted in Covidence according to inclusion and exclusion criteria. Included documents were imported into NVivo, and data from articles were analysed using a thematic analysis approach.
Results
We identified 318 articles through the initial search strategy. After title, abstract and full text screening, we charted data from 32 articles which included lifestyle drift as either a focus or a major theme. Definitions of lifestyle drift included some common elements as well as some variability of concepts. Neoliberalism and the biomedical model were frequently identified as drivers of lifestyle drift across articles. While many strategies to counteract lifestyle drift were proposed, applying a health in all policies approach, and participation from priority populations were the most common strategies suggested.
Conclusion
This scoping review identified that while lifestyle drift is a concept increasingly referred to in public health, health promotion and chronic disease prevention, there remains a need for more empirical research on lifestyle drift, including research that elucidates the mechanisms that contribute to it. If public health initiatives indeed want to focus on upstream interventions that intend to have broad impact and reduce health inequities, perhaps most importantly, research regarding how to identify, prevent and address the phenomenon of lifestyle drift may support these goals.
Prevalence and molecular characteristics of carbapenem-, fosfomycin- and colistin-nonsusceptible ST11 hypervirulent Klebsiella pneumoniae in a teaching hospital
Authors: Yang Yuqi , Ma Kai , Li Xue , Liu Xin , Cheng Ping , Li Lailai , Chai Yihui , Cao Mingle
Published: May 2024

Background: Infections caused by carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HVKP) are a great challenge for physicians in the administration of clinical therapy, and clarification of virulence factors and resistance mechanisms can aid in the selection of appropriate antimicrobial agents.
Methods: We analysed the clinical characteristics of patients with CRKP infection, CRKP susceptibility to clinical first-line antimicrobial agents and resistance genotypes. The lethality and associated virulence factors of CR-HVKP are described. The possibility of the transfer of virulence and resistance genes was also explored. The susceptibility of CRKP and CR-HVKP to last-resort antimicrobial agents was also tested.
Results: CRKP strains were predominantly derived from sputum specimens, urine specimens and blood specimens. Patients with CRKP infections predominantly had pulmonary infections and were predominantly elderly males in the intensive care unit (ICU). CRKP exhibited high resistance to other β-lactam antibiotics, mainly due to the presence of blaKPC, high resistance to quinolones mediated by the carriage of aac (6''-Ib-cr), QnrS and QnrB, and high resistance to aminoglycosides mediated by the carriage of rmtB, ant(3'')-I and armA, respectively. CR-HVKP is mainly composed of ST11 and capsule K1. Aerobactin (iucA, iutA), Ent siderophore (fepA, entB), Salmochelin (iroN), Yersiniabactin (ybtS), Type 3 fimbriae (mrkD), Type I fimbriae (fimH), and Regulation (prmpA) were detected in the CR-HVKP isolates. The CR-HVKP strains had a median lethal dose (LD50) of 2 × 103 to 5 × 103 CFU in the mice, which was similar to that of the positive control NTUH-K2044. Conjugation assays revealed that the genes iucA, iutA, iroN, prmpA, blaKPC, blaNDM, blaVIM, blaSHV, blaTEM, QnrA, QnrB, QnrS, and rmtB can be transferred to E. coli J53. Compared with those of the recipient E. coli J53, the MICs of meropenem, imipenem, levofloxacin and amikacin in the transconjugants increased by 4-128 times.
Conclusions: These findings suggest that virulence and resistance genes may spread rapidly in Enterobacteriaceae, posing a public health risk and a significant threat to clinical care. Therefore, it is necessary to further strengthen hospital infection monitoring, prevention and control measures and to provide strict management and training on the rational use of antimicrobial agents in intensive care units.
Adaptive potential and genomic vulnerability of keystone forest tree species to climate change: a case study in Scots pine
Authors: Łabiszak Bartosz , Wachowiak Witold
Published: May 2024

A better understanding of the possible adaptive response and genomic vulnerability of forest trees is needed to properly assist future forest management and develop adequate resilience strategies to changing environments. Scots pine (Pinus sylvestris L.), a keystone species with extensive distribution and a broad ecological niche, is expected to be directly impacted by climate change due to fitness loss and genetic maladaptation on a large spatial scale. Despite extensive studies that have clarified the broad-scale history and genetic structure of the species, understanding the genetic basis for the local adaptation and genomic vulnerability of Scots pine remains incomplete. Here, we used thousands of genotyped SNP markers in 39 natural populations (440 trees) along a broad latitudinal gradient of species distribution to examine molecular signatures of local adaptation. Specifically, this landscape genomics approach aimed to assess fine-scale patterns of SNPs associated with environmental gradients, predict vulnerability to climate change using genomic offset, and evaluate the adaptive response of populations to projected climate shifts. The variation of outlier SNPs, which exhibits selection signatures between genetically very similar populations in the distribution range, was highly correlated with mean temperature, a key limiting factor for the growth and survival of tree species. Furthermore, our simulation results indicated a high genomic vulnerability on a large spatial scale in P. sylvestris, with the time frame required to close the offset gap by natural selection estimated to be in the range of hundreds of years. The results improve our understanding of Scots pine's adaptive capacity and provide insights for management approaches to mitigate the impacts of climate change on temperate forest ecosystems. By evaluating adaptive responses, the study adds to the discussion on the long-term sustainability of forest ecosystems in the face of ongoing environmental change.
The effect of Corporate Social Responsibility disclosure on Corporate Performance with respect to Mining Companies in Zambia
Authors: Ndemena Peter
Published: May 2024

One of the most important factors in the long-term success of businesses is their ability to fulfil their social responsibilities in an efficient manner. The relationship between corporate social responsibility disclosure and corporate performance will be affected, as a result of the influence of institutions, by the level of social responsibility that the other firm maintains as well as by the level of government subsidies that it receives. The relationship between corporate social responsibility disclosure (also known as CSRD) and corporate performance in the area of reputation, employee and finance is the topic of discussion in this paper, which is based on institutional stakeholder theory. By using relevant data from the mining companies, such as annual reports and interviews, the study aims to examine corporate social responsibility reporting by the mining companies in Zambia in relation to their performance and its overall effects. The study utilized the descriptive research design by employing structured questionnaires and guided interviews that were either physical, virtual or online administered. The population sample was 100 coming from the top 10 mines in Zambia with a calculated sample size of 52 respondents. This study was a qualitative investigation based on interviews. Financial performance, employee commitment, and corporate reputation were measured.
Design and Development of Medical Prescription Writing Robot
Authors: R.Iniyavan  , AFROZ SHAIK , ABID SHAIK , SHUMEEL SUFI MOHAMMAD
Published: May 2024

According In light of the pressing need to address the challenges faced by differently-abled individuals, particularly those with hand impairments, in accessing education and writing examinations, this paper presents the design and development of an innovative Automatic Writing Pen. The project stems from the recognition that conventional methods of writing examinations pose significant hurdles for individuals lacking the use of their hands, limiting their educational opportunities and overall inclusion in society. The Automatic Writing Pen system leverages advanced technologies such as voice recognition and motorized pen movement to enable individuals to write effortlessly without manual intervention. Utilizing a Bluetooth module and a dedicated mobile application, users can input voice commands to the system, which translates these commands into precise movements of the writing pen. The system's design incorporates servo and stepper motors to ensure accurate and flawless writing, mirroring the spoken words with high fidelity.
Boosting the Excellence of Cocoon Production through Silkworm Excreta
Authors: R Shanmugam , A Murugesh K , M Tilak , K Senguttuvan , K Sivakumar , P Radha , P Jothimani
Published: May 2024

Field experiments were conducted for two years to determine the effect of silkworm-rearing waste on the growth and yield of mulberry plants and silkworm growth and economic traits. Methodology: This study consisted of 11 treatments, including an absolute control with 3 replications. The results of this study were as follows: silkworm excreta alone (400 gm/plant yielded the longest shoot, greatest number of branches, greatest number of leaves, highest 100 leaf weight, and highest leaf yield. The silkworm excreta alone at 400 gm/plant had a significant and positive influence on larval and cocoon parameters, which recorded the highest values of larval weight, single cocoon weight, shell ratio, single cocoon filament length, and denier.
Understanding the Causes of Inflation in Madagascar using an ARDL model
Authors: Josué ANDRIANADY Ravahiny
Published: May 2024

This study examines the determinants of inflation in Madagascar using an ARDL model and World Bank data. The results highlight several key factors, including economic growth, fluctuations in oil prices, import dependency, and exchange rate variations, which contribute to inflation in the country. To mitigate inflation, consistent economic policies focusing on promoting balanced growth, economic diversification, and prudent management of external factors are recommended.
Adaptability, stability, and productivity of potato breeding clones and cultivars at high latitudes in Europe
Authors: Ortiz Rodomiro , Reslow Fredrik , Huicho José , Vetukuri Ramesh , Crossa José
Published: May 2024

The aim of potato breeding is to release cultivars showing high and stable performance across the target population of environments. The objective of this research was therefore to investigate the use of various methods (site-regression [SREG], coefficient of variation and the regression’s deviations [σ2δ]) for determining adaptability and stability for productive and quality traits in the Nordic Region of Europe. The multi-environment trials included 256 breeding clones and released cultivars grown by EU farmers at three distinct testing sites over two years in Sweden. There was significant (P < 0.001) variation for tuber yield, starch percentage and reducing sugars in the tuber flesh among breeding clones and cultivars, testing environments and their GEI. The environments were very diverse as revealed by SREG biplots and particularly for the GEI patterns noted in productive and quality characteristics. The percentage of stable high-tuber yielding germplasm was larger for breeding clones (23%) than for the European released cultivars (2%), thus showing the advantage of potato breeding in the target population of environments. SLU 1415001 and SLU 1314015 were the most promising breeding clones due to their stable high tuber yield. The starch potato cultivars were the best for this characteristic, although none of them had a non-significant σ2δ. ‘Talent’ shows an almost stable good performance among low reducing sugar cultivars and breeding clones, which were often unstable in their scoring across environments. Neither a breeding clone nor a cultivar was at the top ranking for stable tuber yield, tuber flesh starch and reducing sugars in the tuber flesh, which shows the challenge faced by potato breeding while addressing the need of different markets.
Fatwa Institutions in Handling Religious Blasphemy Crimes in Indonesia and Malaysia
Authors: Ilahi M. Ridho , Irfan M. Nurul , Kamarusdiana Kamarusdiana , Hidayatulloh Hidayatulloh , Zulfa Eva Achjani
Published: May 2024

The position of fatwa institutions in cases of blasphemy by cult groups is often seen as representing only the majority Muslims and blaming minority Muslims, as in Indonesia, or seen as a tool to suppress anti-government groups, as in Malaysia. This study aims to explain the position of the Indonesian Ulema Council (MUI) and Jawatankuasa Fatwa in handling heresy, including the reasons behind the differences in the positions and roles of the two institutions. Researchers use qualitative methods with a comparative legal approach. This study found that MUI's heretical fatwas had no legal force, the central MUI has the authority to enact heretical fatwas within MUI institutions, but not absolutely to respond to national laws, and not play a role in the criminal justice system. Meanwhile, Jawatankuasa Fatwa Kebangsaan (JFK) has the force of law with certain conditions, however, the federal state Jawatankuasa Fatwa has the authority to determine heretical fatwas to respond and strengthen state regulations (blasphemy laws). This research can be used as a reference for law enforcement in handling blasphemy cases by considering the views of MUI and Jawatankuasa Fatwa, which are regulated adequately by laws and regulations.
The Critique toward Uṣūl al-Fiqh Literacy of 1890–2023: An Offer for Development
Authors: Khoir Tholkhatul , Munawaroh Lathifah , Bin Hassan Zainudin
Published: May 2024

Critique of uṣūl al-fiqh literacy is very crucial. The scarcity of critique can lead to the risk of intellectual stagnation and an inability to address the legal needs of a constantly changing society, simultaneously causing a lack of resonance with reconstructive ideas. The study aims: 1) to explore evidence of the scarcity of studies criticizing uṣūl al-fiqh from 1890 to 2023; 2) to explain the factors influencing the scarcity of critical works, and 3) to propose steps for the reconstruction of uṣūl al-fiqh. The data sources for this article are works collected from web publishers, digital libraries, and search engines. The data obtained was mapped and analyzed, and its trends were recorded. This study finds that during the period 1890-2023, criticism was the rarest aspect in uṣūl al-fiqh literature. The factors causing the scarcity of critique vary and complement each other, involving scholarly elements, uṣūl al-fiqh factors, and surrounding policies. Although criticism of uṣūl al-fiqh is relatively rare, it does not mean there is no space for reconstruction. Through this study, readers can understand the recent developments in uṣūl al-fiqh and assess the extent to which criticism has been undertaken while reflecting on how reconstruction can be initiated once again.
National Security in the Conditions of the Russia-Ukraine War: Legal Regulation and Islamic Law Perspectives
Authors: Shkuta Oleh , Leheza Yevhen , Telelym Iryna , Anosienkov Anatolii , Yaroshak Oleh
Published: May 2024

National security is an important condition for the functioning and development of individuals, societies, and the states, however, this security is threatened by war, and global military conflicts. This article aims to describe the national security threatened by the Russia-Ukraine war and all its effects from the context of legal regulation and Islamic law. This article is qualitative research with a historical and comparative approach. The study results concluded that Russia's full-scale invasion of Ukrainian territory, the formation of a new international military alliance, and the establishment of international cooperation to strengthen the security of the world community, were identified as innovative ways to develop international and global security. This is important to ensure national security in wartime conditions is maintained because security is a basic need that must be guaranteed in the context of national law, human rights, and Islamic law.
In the Name Religion and Defending Women; Experiences of Three Pesantren Women in Indonesia Local Elections
Authors: Chalik Abdul
Published: May 2024

The leadership of Indonesian Muslim women experienced a development, marked by the ever extensive political roles. Some previous researches state that the factor of familial closeness (political dynasty), gender, collusion, sexiness and piety marketing stimulate women’s election in political contestations. But these reasons are not enough to explain the reason for women’s roles in the public, especially women of pesantren (Islamic boarding schools). We suggest that women’s courage in the struggle for the political position is due to their desires to strive for women's rights that are ignored and not comprehensively understood by male leaders. The existence of the thought that women can (only) ‘understand women’ becomes the reason why regional leaderships are also seized by women. The article also shows the ability to integrate spirituality towards public roles by utilizing their social capitals. This paper also counters some arguments that women always lose in public sectors in political sector fights as they are under the shadow of their husbands or men.
Analisis Gaya Kepemimpinan Otoriter Pemerintah Serta Kaitannya dengan Teori Demokrasi
Authors: Salsabilla Salsabilla , Assakhawi Ananda Zhafir , Fathullah Muhammad Adib , Rahmawati Nurlaili
Published: May 2024

Penelitian ini bertujuan untuk membahas Konsekuensi Kepemimpinan Otoriter Terhadap Prinsip-Prinsip Demokrasi; Perbandingan Kebijakan dan Praktik Pemerintahan antara Gaya Pemerintahan Otoriter dan Demokratis; serta implikasi gaya kepemimpinan otoriter di berbagai negara. Menggunakan metode penelitian deskriptif dengan literatur review. Hasil dari penelitian ini adalah Melihat kasus-kasus di negara dengan gaya kepemimpinan otoriter seperti Rusia, Venezuela, Tiongkok, dan Arab Saudi, kita dapat melihat bahwa pemerintahan otoriter seringkali menghasilkan situasi di mana hak asasi manusia menjadi rentan. kepemimpinan otoriter seringkali menciptakan situasi di mana hak-hak individu diabaikan atau bahkan diperlakukan dengan semena-mena. Sehingga perlu adanya kesadaran global tentang isu-isu pelanggaran HAM karena gaya kepemimpinan otoriter, agar semakin besar peluang untuk mendorong perubahan positif dalam perlindungan hak asasi manusia dan pemerintahan yang lebih demokratis di seluruh dunia.
Análise multitemporal da linha costeira na Costa do Cacau, Bahia
Authors: De Araújo Limoeiro Milena , Souza dos Santos Wemerson
Published: May 2024

A Costa do Cacau, localizada no litoral sul do estado da Bahia, é uma região muito importante do ponto de vista ambiental por abrigar uma das maiores biodiversidades do planeta. Além disto atrai bastante atividade turística devido às belezas de suas praias distribuídas ao longo de cerca de 180 km de faixa litorânea. No entanto, assim como acontece em toda zona costeira, vem sofrendo com o avanço e o recuo da linha de costa, que muda constantemente de posição em várias escalas temporais, intensificando a necessidade da realização de estudos, que visem entender a dinâmica da linha de costa na região, como subsídio para a manutenção e proteção deste ambiente. Neste sentido, este trabalho tem sua relevância destacada, pois tem o objetivo de caracterizar as variações espaço-temporais da linha costeira na região da Costa do Cacau no intervalo de tempo decadal, entre o período de 1990 a 2020. Realizou-se análise histórica da linha de costa através de imagens orbitais multiespectrais com baixa cobertura de nuvens para a região de estudo, provenientes da série dos satélites Land Remote Sensing Satellite (LANDSAT). Para o período de análise, de médio prazo, 30 anos, utilizou-se quatro linhas de costa, dos anos de 1990, 2000, 2010 e 2020. Concluiu-se que, o estudo forneceu de forma quantitativa e qualitativa, a análise da dinâmica da linha de costa na região da Costa do Cacau. A área total modificada pelos processos de acreção e erosão aumentou significativamente entre o primeiro (1990-2000) e o último (2010-2020) período de intervalo decadal investigado. Ressalta-se que, considerando a importância social, econômica e ambiental da Costa do Cacau, há a necessidade de um monitoramento contínuo com a finalidade de melhor compreender a dinâmica costeira desta região.
Análise da Implantação de Reservatórios de Detenção em Lotes Urbanos
Authors: De Sousa Lima Neto Vicente , Roberto Lacerda Tavares Paulo , Holanda de Castro Marco Aurélio , Joaquim da Silva Pereira Cabral Jaime
Published: May 2024

A impermeabilização das bacias hidrográficas aumenta o escoamento superficial e diminui a infiltração de água no solo. Nesse contexto, as inundações ocorrem com maiores frequências e magnitudes, provocando perdas econômicas, poluição, problemas de saúde, interrupções de tráfego e perdas humanas. Este trabalho teve por objetivo analisar o amortecimento de cheias por meio de reservatórios de detenção nos lotes urbanos instalados na cidade do Crato, Ceará, Brasil. Um sistema de drenagem urbana foi dimensionado e simulações foram realizadas no SWMM. A partir de cenários sem a presença da estrutura LID e com reservatórios de detenção, a vazão de pico de sub-bacias, vazão de pico e lâminas d’água nas galerias, vazão de pico e volume escoado nos exutórios do sistema foram avaliados. Os resultados mostraram que os reservatórios de detenção foram capazes de reduzir a vazão de pico nas sub-bacias e nas galerias em média com valores máximos de 83% e 71%, respectivamente, e 52% da lâmina d’água relativa máxima nas galerias. O volume escoado e vazão de pico nos exutórios tiveram reduções máximas de 68% e 69%, respectivamente. Logo, a instalação dessas estruturas possibilitou um melhor gerenciamento do balanço hídrico da bacia hidrográfica, com previsão de diminuição de ocorrências de inundações.
Assessment of the Dynamics of Structural Changes in the Socio-Economic Environment and Their Typology in the Context of a Statistical Approach
Authors: Kremlev N. D.
Published: May 2024

The purpose of the study is to substantiate the documentation for assessing the dynamics of structural changes in the socio-economic environment and their typology. The relevance of the study is related to the problems of reflecting the socio-economic environment, which affect the efficiency of economic activity. To address these issues, many regions of the country have adopted regional development strategies for the period up to 2030, which correspond to the national development goals of the Russian Federation. Various approaches of scientists to determining the essence and significance of the socio-economic environment, which is defined as a set of conditions and factors that influence all sectors of the economy, are studied.Methods: structural, index, comparative estimates and methodology of the system of national accounts.Results: the article uses a digital meter as a reproduction of the population and gross regional product (GRP), which objectively reflect the structural changes and typologies of the regions. GRP is calculated by types of economic activity, at the stages of: production, income generation and final consumption of households 2012-2021. Typologies of the Ural regions have been developed according to the following criteria: specialization of the economy, the position of the region in production, by types of primary income and final consumption of households per capita.Conclusion: the advantage of the statistical approach of studying the assessment of the dynamics of structural changes in the socio-economic environment and their typology allows us to get a more objective idea of the prevailing trends and the state of the regional economy. The results obtained made it possible to formulate a methodological basis for future scientific research in the field of structural changes in the meso-environment and socio-economic behavior of the population. They can also be used as a methodological basis for the development of public policy measures and strategies for sustainable development of territories in the future.
Maximizing ISRIB Potential Requires Addressing Specificity, Long-Term Safety, and Disease-Specific Considerations
Authors: Boretti Alberto , Banik Bimal
Published: May 2024

Background:

Integrated Stress Response Inhibitor (ISRIB) works by inhibiting
the integrated stress response, a cellular pathway involved in the regulation of protein
synthesis during stress conditions. Conditions that have been studied or suggested
as potential candidates for treatment with ISRIB include neurological and metabolic disorders,
cognitive impairment, viral infections, and cancer.

Objective:

The study aimed to discuss the challenges related to specificity, long-term
safety, and disease-specific considerations crucial for realizing the full potential of ISRIB.

Method:

A narrative review of the literature has been conducted to delve into ISRIB's
chemistry, mechanisms of action, disease-specific considerations, and long-term safety
implications.

Results:

While ISRIB has shown promising results in preclinical studies, more research
is needed to determine its safety and effectiveness in human patients. Clinical trials are
required to validate its therapeutic potential for various conditions. Despite having been
proposed a decade ago, news of its clinical trials has been circulated only recently, without
any published information yet and with rumors that its efficacy vs. safety profile
may be compromised by side effects.

Conclusion:

While ISRIB offers exciting prospects for a range of biomedical applications,
addressing challenges related to specificity, disease-specific considerations, and
importantly long-term safety, is crucial for realizing its full potential.
Clinical Significance of a Novel Vasculogenic Mimicry-Based Prognostic Model in Hepatocellular Carcinoma
Authors: Zeng Yifan , Jiang Shuwen , Lou Zhuoqi , Chen Lin , Zhang Yongtao , Pan Liya , Shi Qingmiao , Ruan Bing
Published: May 2024

Background:

Vasculogenic mimicry, a novel neovascularization pattern of
aggressive tumors, is associated with poor clinical outcomes.

Objective:

The aim of this research was to establish a new model, termed VC score, to
predict the prognosis, Tumor Microenvironment (TME) components, and immunotherapeutic
response in Hepatocellular Carcinoma (HCC).

Methods:

The expression data of the public databases were used to develop the prognostic
model. Consensus clustering was performed to confirm the molecular subtypes with
ideal clustering efficacy. The high- and low-risk groups were stratified utilizing the VC
score. Various methodologies, including survival analysis, single-sample Gene Set Enrichment
Analysis (ssGSEA), Tumor Immune Dysfunction and Exclusion scores
(TIDE), Immunophenoscore (IPS), and nomogram, were utilized for verification of the
model performance and to characterize the immune status of HCC tissues. GSEA was
performed to mine functional pathway information.

Results:

The survival and immune characteristics varied between the three molecular
subtypes. A five-gene signature (TPX2, CDC20, CFHR4, SPP1, and NQO1) was verified
to function as an independent predictive factor for the prognosis of patients with
HCC. The high-risk group exhibited lower Overall Survival (OS) rates and higher mortality
rates in comparison to the low-risk group. Patients in the low-risk group were predicted
to benefit from immune checkpoint inhibitor therapy and exhibit increased sensitivity
to immunotherapy. Enrichment analysis revealed that signaling pathways linked to
the cell cycle and DNA replication processes exhibited enrichment in the high-risk
group.

Conclusions:

The VC score holds the potential to establish individualized treatment
plans and clinical management strategies for patients with HCC.
Curcumin Mitigates Streptozotocin-Induced Genotoxicity In Vivo by Activating P53 Protein and Inhibiting Oxidative Stress and Chromosomal
Aberration
Authors: Saha Alik , Chakrovorty Arnob , Bhattacharjee Banani , Nandi Sisir , Samadder Asmita
Published: May 2024

Background:

Genotoxins are chemical constituents that damage DNA or chromosomal
architecture, leading to alterations in the genetic level. Streptozotocin, a monofunctional nitrosourea
derivative, is often utilized to induce diabetes mellitus in laboratory animals because
of its detrimental effects on pancreatic cells. The purpose of this work was to investigate possible
protective efficacy against the genotoxic effects of Streptozotocin.

Objective:

This study examines the potentiality of curcumin, a phytoproduct with anti-genotoxic
and anti-diabetic qualities, against streptozotocin-induced chromosomal abnormalities and DNA
damage. The study evaluates the possible protective efficacy of curcumin, exploring a variety of
biochemical and molecular biology techniques in murine models.

objective:

This study investigates the potential of curcumin, a phytoproduct having anti-genotoxic and anti-diabetic qualities, against streptozotocin-induced chromosomal abnormalities and DNA damage. The study evaluates the possible protective effects of curcumin using a variety of biochemical and molecular biology techniques in murine model.

Methods:

The experiment involves a control group, the administration of Streptozotocin (Group
S), and a curcumin-pretreated STZ group (Group SC) in mice. The effects of curcumin on DNA
damage and chromosomal aberrations were investigated by histopathology, immunofluorescence,
evaluation of chromosomal aberrations, detection of Reactive oxygen species, cell viability
analysis, and DNA laddering assay.

Results:

The results demonstrated a significant reduction in DNA damage, chromosomal anomalies,
and a decrease in the expression of the p53 protein in the curcumin-treated animals compared
to that of STZ-treated mice.

Conclusion:

The overall results show that curcumin can reduce chromosomal aberrations and
DNA damage by altering the expression of p53 repair proteins. This suggests that curcumin has
a promising future as a therapeutic agent, especially when it comes to drug-induced toxicity and
the development of novel therapeutics.

other:

NA
Current Developments in the Prevention and Improvement of Intestinal
Disorders: A Mini-Review
Authors: Santa Kazuki , Ohsawa Tomonori
Published: May 2024

Background:

Recently, the number of patients who manifest intestinal disorders has
increased. Particularly, Irritable Bowel Syndrome (IBS) patients and Inflammatory Bowel Disease
(IBD) patients, which include Ulcerative Colitis (UC) and Crohn’s Disease (CD), are on
the rise, especially in the young generation. Behcet’s disease (an autoimmune disease) and bowel
obstruction are also common intestinal disorders. Furthermore, colorectal cancer, including
colon and rectum cancer and small intestinal cancer, are the typical disorders in the intestine.
Other disorders in the digestive tract are infectious diseases like Helicobacter pylori infection.
Even though symptomatic treatments have been increasing for the treatment of intestinal disorders,
the ways of improving and preventing these diseases are still controversial.

Objective:

The progress of medicine and treatment is rapid. However, recent approaches to the
prevention and improvement of these intestinal disorders are suppressing dysbiosis and preventing
chronic inflammation. This mini-review discusses the hypothesis of whether the improvement
of the diet is a preferable choice for the prevention of these intestinal disorders. Dietary
interventions are beneficial for the prevention and improvement of intestinal disorders since the
first approach to intestinal disorders is dietary intervention. The Mediterranean diet, the diet
from the 5-a-day campaign, and the Japanese diet are well-known healthy dietary strategies. A
healthy diet regimen is not only beneficial for the prevention of intestinal disorders but also a
useful strategy to reduce stress and ameliorate mental illness. In addition, the intake of phytochemicals
is good for keeping healthy gut microbiota and preventing intestinal disorders. Furthermore,
vitamin D3 intake with these phytochemicals works as an adjuvant to improve gut
microbiota and upregulate immune responses. As a result, the decreasing production of TNF-α
ameliorates chronic inflammation and intestinal disorders at an early stage.

Conclusion:

In recent years, prevention of the non-disease condition “ME-BYO” has been a
popular approach for healthy and long living in Japan. This idea prevents the manifestation of
diseases before the onset and is also applicable to intestinal disorders. This mini-review discusses
ways of preventing and ameliorating intestinal disorders.
Research Status and Development Trend of Multi-arm Collaborative
Robots
Authors: Han Lu , Yan Farui , Xie Xuedong , Yang Yongqi , Xie Baocheng
Published: May 2024

Industrial robots are mainly used in metal forming, automotive, and electrical and electronics
industries. After decades of unremitting efforts, industrial robots have achieved great success.
However, problems such as low safety, weak environmental adaptability, and insufficient humancomputer
interaction ability of industrial robots have greatly limited the application of industrial
robots, and multi-arm collaborative robots came into being in this case. Multi-arm collaborative robots
offer high flexibility and precision. Over the years, the application and development of multiarm
collaborative robots have been paid more and more attention. This paper aims to summarize the
patents related to multi-arm cooperative robots, including their principles, classification, latest progress
and future development, in order to meet the needs of the real world. According to the structural
characteristics of multi-arm collaborative robots and the requirements of multi-arm collaborative
robots application field, the most typical mobile collaborative robots and stationary dual-arm collaborative
robots in multi-arm collaborative robots are summarized. By investigating various patents of
multi-arm collaborative robots the main problems of multi-arm collaborative robots are summarized
and analyzed, such as collisions or conflicts between robotic arms, low power-to-weight ratio, loose
structures, and heavy weight of the robot body. In addition, the development trend of multi-arm collaborative
robots is also discussed. Multi-arm robots have broad prospects and potential in future
applications and development. With the advancement of new technologies, multi-arm collaborative
robots will become more efficient, intelligent, safe, and flexible. More relevant patents are expected
to be invented in the future.
Herbal Medicine Use among Adult Lebanese Patients with Chronic Diseases: A Descriptive Cross-sectional Study
Authors: Assi Mohammad , Fahs Iqbal , Lteif Rebecca , Hallal Zahraa , Hdaib Fadi
Published: May 2024

Introduction

Herbal products are used for the management of various chronic diseases. This study sought to determine the frequency of herbal medicines use among Lebanese patients diagnosed with chronic diseases, their patterns, underlying causes and perceived efficacy.

Methods

This is a descriptive cross-sectional study that enrolled Lebanese adult patients from the six governorates of Lebanon between February and December 2020. Those who had hypertension, diabetes mellitus, dyslipidemia, chronic constipation, or rheumatoid arthritis were eligible for enrollment.

Results

A total of 300 patients participated in this study. Around 123 participants (41%) reported using herbs. The majority purchased the herbs based on a suggestion (47.2%) from a friend or a family member. The most commonly used herbs were Pimpinella anisum, and Garlic (15.8%) for hypertension, Sage (26.9%) and Stevia (23.1%) for diabetes mellitus, Red Yeast Rice (27%) and Hawthorn (23%) for dyslipidemia, and Senna (43.6%) and Artichoke (25.8%) for chronic constipation, and Curcumin (46.2%) and Allium sativum (30.8%) for rheumatoid arthritis. The majority did not have an idea about the side effects (87.8%), drug-herbal interactions (95.1%), or drug-disease interactions (96.8%) of herbs. Most of the patients (65%) were satisfied with the herbal product use.

Conclusion

The use of herbal medicines is common among adult Lebanese patients diagnosed with hypertension, diabetes, dyslipidemia, arthritis, and constipation. However, herbal products are not risk-free. Hence, further research in this area is warranted.
Analysis of Associated Factors Contributing to Type 2 Diabetes Mellitus in the Coastal Community of Bahari Village, Southeast Sulawesi, Indonesia: A Cross-Sectional Study
Authors: Muhammadong Jumadi , Yuyun Wa , Muriman Laode Yusman , Azis Waode Azfari , Subhan Muhamad
Published: May 2024

Background

Type 2 diabetes mellitus (T2DM) has become a major lifestyle disease that threatens communities in the world. The lifestyles of undiagnosed T2DM are a major issue in Indonesia.

Objective

This study aims to analyze the contribution of associated factors to T2DM in Bahari Village.

Methods

The study was conducted by cross-sectional study. Respondents included 113 men and 157 women were established through simple randomized sampling from March to May 2023. Data analysis using chi-square and logistic regression at p<0.05 using SPSS 25.

Results

The prevalence of T2DM for women (74.2%), 45-65 years (90.9%), no education (58.7%), overweight (38.2%), heavy drinking sweet tea/coffee (77.5%), never physical activity (87.1%), diabetic father and mother (40.3%), and father’s OR 1.42 (CI 95%:0.73-2.75), significantly associated with T2DM. Gender, age, education, BMI, and occupation simultaneously influence (72.7%), and age partially affects T2DM.

Discussion

Decreased insulin sensitivity and increased risk of developing diabetes can be influenced by various factors, such as genetics, lifestyle, physical activity, and the environment, either partially or simultaneously.

Conclusion

The respondents' advanced age, obesity, lack of education, preference for sweet foods, and inactivity all contributed to their type 2 diabetes. These coastal communities need to make lifestyle changes to reduce the burden of diabetes.

Classification

Epidemiology; Environmental Health; Science of Nutrition MeSH.