bluuebunny/crossref_metadata_2025 huggingface dataset:
Transformative Politics in Russia: social actors and political institutions in the space of power and domination : [monograph]
Authors:   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation, Aivazova S.G. , Zhavoronkov A.V. ,   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation, Patrushev Sergey V. ,   Institute of Sociology of FCTAS RAS, Moscow, Russian Federation
Published: January 2025

Монография завершает цикл исследований политико-институциональных проблем России периода становления чиновничье-олигархического капитализма. Рассмотрены возможности, ограничения и сценарии трансформативной политики в условиях незавершенной институционализации государства.
Выявлены институциональные основания перспективных стратегий политических изменений. Работа выполнена в рамках политической социологии, институциональной и гендерной политологии. В монографии обобщены и дополнены результаты многолетней работы авторов по исследованию характера власти и политики современной России. В приложении представлены результаты обследований 2020–2022 гг., позволяющие читателю дать собственные оценки.
Для научных сотрудников и преподавателей вузов, аспирантов, магистрантов и студентов старших курсов политологов, социологов, философов, специалистов в области государственного и муниципального управления.
Arriería, vínculos comerciales y una alianza: el matrimonio Navarro-Frías, su ascendencia y descendencia (Tucumán, 1818-1961)
Authors: Navarro Ibarra Liliana
Published: January 2025

En el presente trabajo se exploran distintos aspectos asociados a la ascendencia y descendencia del matrimonio conformado por don Manuel José Braulio Navarro (San Juan, 1818 - Tucumán, 1877) y doña Gregoria Eladia Exaltación de la Cruz Frías (Tucumán, circa 1839 - Tucumán, 1901), en pos de dilucidar el conjunto de motivos que habrían llevado a este arriero no sólo a desplazarse sino también a asentarse en territorio tucumano. También, los mecanismos y estrategias de reproducción social del grupo familiar. Para ello se ha recabado información en diferentes libros sacramentales y expedientes judiciales –tanto de San Juan como de Tucumán–, los dos primeros censos nacionales de la República Argentina (1869 y 1895), actas provenientes de juzgados de paz y documentos editados, como el Archivo del Brigadier General José Nazario Benavides (2007).
El primer carlismo en la provincia de Córdoba (1833 - 1840): una propuesta de interpretación socioeconómica
Authors: Rueda Calle Juan Jesús
Published: January 2025

Aunque Andalucía fue una región en la que la primera guerra carlista tuvo un impacto muy moderado, la provincia de Córdoba fue uno de los focos calientes del conflicto. Este estudio persigue la síntesis, combinando fuentes secundarias y primarias (a destacar el Boletín Oficial de la Provincia de Córdoba) de los principales hechos de relevancia acaecidos en la región, así como las formas de apoyo que recibió el carlismo, como paso previo para el estudio de su distribución geográfica, sus bases socioeconómicas y las posibles motivaciones que sirvieron como acicate para la movilización política de dichas bases. Para ello, se ha hecho un estudio prosopográfico de la extracción socioprofesional de 41 carlistas encontrados en las fuentes así como de las características, contrastadas para su evolución en un período amplio gracias al Censo de Floridablanca y al Diccionario de Pascual Madoz, de aquellas regiones de  la provincia con mayor efervescencia carlista que puedan contribuir al estudio de la adscripción al carlismo.
Marimon, superintendentes de las Reales Atarazanas de Barcelona: un linaje catalán al servicio de la monarquía (siglos XVII-XVIII)
Authors: Chamorro Esteban Alfredo
Published: January 2025

Desde la década de 1620 la familia Marimon siempre dio muestras de su fidelidad a la monarquía y de estar al servicio de los reyes, tanto de la Casa de Austria como de los Borbones. Durante los siglos XVII y XVIII los miembros de este linaje ocuparon importantes cargos en Cataluña, siendo uno de los pilares que sostuvieron el poder real en el Principado y que les valió la concesión del título de marqueses de Cerdanyola.
Fold-Related Faults Track Progressive Fold Development from Layer-Parallel Shortening to Subsequent Orthogonal Extension within an Appalachian Buckle Fold System: Bear Valley Mine, Shamokin, PA, USA
Authors: Weil Arlo Brandon , Gray Mary Beth , Cush Kylie G. , Needle Mattathias D. , Crider Juliet G.
Published: January 2025

Outstanding three-dimensional exposures of adjacent folds in an abandoned coal mine within the Appalachian Valley-and-Ridge tectonic province permit a detailed analysis of macroscopic strain accommodation by minor faulting in the lead up to and during buckle folding. A kinematic analysis of more than 900 outcrop-scale faults coupled with clearly established relative age relationships allows delineation of distinctive fault sets and their roles in accommodating strain within a quartz-dominated sandstone and an overlying silty shale. Conjugate contractional faults are interpreted as evidence of layer-parallel shortening (LPS) prior to and during fold initiation, based on geometric relationships to primary bedding. A clearly overprinting population of younger conjugate faults accommodate layer-parallel extension (LPE) that is both parallel and perpendicular to the fold axes; they are interpreted to have developed during fold limb rotation and fold tightening. Curving and overprinting slip lineations on some strike-slip faults track the transition from LPS to LPE during fold growth. Although the fault-related extensional linear strain magnitudes are relatively small, LPE faults are present in all fold dip domains, in two contrasting lithologies, and on adjacent open and tight folds, highlighting the importance of minor faulting and LPE strains in the formation of contractional buckle folds in the shallow crust. Our findings do not strictly conform with those predicted by classical conceptual models of buckle folds, such as orthogonal flexure or flexural slip. The work further suggests that bed-parallel extension, both axis-parallel and perpendicular, is an underappreciated component of three-dimensional, buckle folding–induced strain and that models for minor fault sets that accommodate three-dimensional strain during fold formation are currently incomplete.
Research on Physical Simulation Model Production and Remaining Oil Distribution Based on Fluvial Compound Sand Body Architecture
Authors: Cao Weijia , Qi Yukun , Xie Kun , Yan Kun , Lu Xiangguo , Bai Mengyu , Wang Yongjiang , Wei Wei
Published: January 2025

Bohai offshore oil fields have reached the stages of high and ultrahigh water content, resulting in a significant amount of remaining oil within reservoirs after long-term waterflooding. For typical offshore oil fields characterized by wide well spacing and sparse well networks, the river facies composite sand bodies pose a challenge. It remains unclear how the configuration of these composite sand bodies affects the spatial sweep characteristics of injection agents, as well as the formation and distribution of residual oil. This study employs a seismic-guided method, integrating well logging and seismic data, to examine the stacking patterns of fluvial compound sand bodies in a typical offshore oil field. A 3D physical model of composite sand bodies with varying stacking relationships was established to carry out physical simulation experiments involving waterflooding and chemical flooding. This study aims to investigate how the interface and differences in the physical properties of composite sand body configurations affect the distribution of remaining oil. Results reveal that the stacking characteristics of fluvial compound sand bodies in the Bohai oil field are represented by three main configuration patterns—the abandoned river channel type, the side edge contact type, and the main body cutting and stacking type. Unlike the laterally structured compound sand body, the vertically superimposed compound sand body configuration in the target reservoir minimizes flow resistance and enhances the effectiveness of swept volume expansion. This ultimately results in improved recovery rates during both waterflooding processes. Furthermore, in a configuration featuring one horizontal injection well paired with two vertical production wells, the injection point benefits from a larger filtration area and a broader sweeping range. Nonetheless, there are difficult-to-sweep areas resulting in higher residual oil saturation. Utilizing a horizontal well arrangement allows for a larger permeable zone, which in turn minimizes the water-fingering effects. Following the waterflooding process, the water ridge at the injection side appears relatively gentle, while the wings at the production side are considerably steeper. Following waterflooding in the 3D physical models, the application of gel plugging combined with microsphere and surfactant profile control and flooding can effectively use the remaining oil. Polymer gel shows a good plugging effect on the high-permeability layer, significantly increasing injection pressure after plugging. This prompts the subsequent polymer microsphere and high-efficiency oil displacement agent to move into the residual oil enrichment area, improving oil recovery by 22.78–26.26% compared with waterflooding alone.
Intelligent Robots, Cyborgs, Genetically Enhanced Individuals, Chimeras: the Future and the Challenges of Law
Authors: Filipova I. A.
Published: January 2025

Objective: to identify theoretical and legal problems associated with the steadily increasing spread of digital and biotechnologies’ development products; to assess the risks associated with this process that can change the position of a human in the society of the future; to develop and substantiate proposals to minimize risks and eliminate the identified problems through legal regulation.

Methods: the research is based on the methods of generalization of scientific and technical information and theoretical analysis used while studying the source materials; axiological and systematic approaches; the formal legal method and, in addition, methods of legal forecasting, primarily extrapolation, which made it possible to highlight the prospects for reforming law due to technological expansion.

Results: include a description of the dynamics of digital and bio-technologies’ development; a description of the changing social landscape with the emerging new types of entities that can affect the actual status of a human; a classification of risks threatening people due to the digital and biotechnologies development; a list of tasks whose solution based on law will help to eliminate, postpone or, at least, significantly reduce the severity of problems by increasing the time limit allotted to humanity to comprehend a number of conceptual points. The author presents arguments substantiating the need to develop special legal regulation in relation to new types of entities, the appearance of which becomes an inevitable result of the mentioned technologies’ development.

Scientific novelty: consists, first, in a comprehensive study of the development of interconnected groups of digital and biotechnologies, taking into account their increasing convergence; and, second, in the formulation of legal problems that need to be resolved due to the potential emergence of new types of entities with cognitive functions and capable of having a targeted intellectual impact on the environment and legal entities.

Practical significance: it is present in the answers given to the formulated legal questions, which contain suggestions and recommendations on the necessary adjustment of legal regulation and focus the attention of legal scholars on the problems arising from the pace and vectors of scienceconsuming technologies’ development.
Legal Aspects of Granting Subjectivity to Artificial Intelligence: Prospects of Using Robots in Legal Practice in Nigeria
Authors: Ikubanni O. O. , Oyebanji O. A. , Оyebade A. A.
Published: January 2025

Objective: to determine the potential and acceptability of using artificial intelligence in legal activities according to the Nigerian law.

Methods: the research is based on scientific analysis, as well as formallegal, comparative-legal, historical-legal and systemic-functional methods. The scope of the research is represented by the norms of legislation, including expired normative legal acts, as well as scientific monographic and periodical literature.

Results: It was found that artificial intelligence and robot lawyers are inevitable innovations in the legal practice of many countries, including Nigeria. The use of these digital technologies has proven to be highly effective in activities related to the administration of justice, providing assistance in four areas of legal services: consulting and guidance, searching for materials, data analysis and forecasting the trial results. Technology greatly facilitates the work of lawyers, given the amount of legal services. In addition, the author show that while the use of artificial intelligence may generally be considered justified, the involvement of robot lawyers in legal practice in Nigeria facesboth legal and ethical barriers. The laws on legal education and legal practice in force in this country do not recognize robot lawyers as persons licensed to practice law in Nigeria. Robot lawyers must be given the status of a person before they can fully implement their potential in the legal practice of Nigeria.

Scientific novelty: this is primarily due to the formulation of a research task to determine the possibility of a robot acting as a practicing lawyer within the legal framework in Nigeria.

Practical significance: the conclusions formulated in the paper, namely, the inevitability of using artificial intelligence and robot lawyers in legal practice and the current legislation governing legal practice in Nigeria, will be useful when considering amendments to legislation in order to adapt it to the current level of digital technology development.
Countering Cyberattacks: Gaps in International Law and Prospects for Overcoming them
Authors: Rahman M. M. , Das T. K.
Published: January 2025

Objective: to categorize cyber attacks in the national and international legal sytems and to define legal measures to counter them at the international level.

Methods: include doctrinal legal analysis, formal legal, comparative legal methods, synthesis, induction, deduction, as well as methods of legal forecasting and modeling. International legal documents and acts of national legislation, judicial precedents, and doctrinal sources were studied.

Results: the article defines the legal consequences of cyberattacks, identifies difficulties in determining and holding individuals and organizations accountable for their commission, identifies national measures to counter cyberattacks based on the principle of proportionality, and systematizes the international legal framework for responding to cyberattacks. The main focus is on the urgent problems of identifying and verifying cyber weapons, establishing international standards for their use, developing methods of disarmament or limiting offensive cyber capabilities. The authors raise the issue of ensuring humanitarian activities, protecting critical infrastructure and the population through cybersecurity measures in wartime. The legal framework is analyzed; gaps and other defects are identified in the current regulation of exercising jurisdiction in such areas of cyber activity as international transactions, data localization and extraterritorial enforcement of national legislation. The parameters were developed and described within which states may conduct proactive cyber operations to prevent or deter cyberattacks (cyber countermeasures). The main parameters are due diligence, legal decisions on using cyber countermeasures, proportionality of protection measures to the consequences of illegal actions.

Scientific novelty: this is due to the progressive solutions in the field of international legal regulation of cyber countermeasures by states responding to cybercrime. The solutions are formulated taking into account the impact of the countermeasures on human and civil rights and freedoms, including the right to privacy and freedom of speech.

Practical significance: the research results can be used to develop and improve international legal instruments in the field of combating cyberattacks and ensuring cybersecurity, and can serve as a model for national legislators when designing law-making solutions to counter cybercrime.
Methods for randomized, blinded, controlled evaluation of putative disease interventions in multi-laboratory, preclinical assessment networks
Authors: Nagarkatti Karisma , Diniz Marcio , Cabeen Ryan , Estrada Monica , Crawford Karen , Rogatko Andre , Kim Sungjin , Ayata Cenk , Chauhan Anil , Hess David , Khan Mohammad , Kumskova Mariia , Leira Enrique , Patel Rakeshkumar , Lyden Patrick , Lamb Jessica
Published: January 2025

Science faces a reproducibility crisis, and public trust in science suffers when large clinical trials—qualified by promising preclinical studies—fail. While some clinical trial designs may have been inadequate, preclinical assessments of disease interventions have lacked key elements of rigor: treatment concealment, randomization, blinded outcomes, pre-specified and adequate sample sizes, and models including co-morbidities. To demonstrate feasibility and practicality of enhanced rigor in preclinical assessment, a six-laboratory network was designed that implemented rigorous study elements, using acute ischemic stroke for demonstration. This network enrolled 2615 animals in five different models and implemented a multi-stage, multi-arm statistical design that sequentially eliminated candidate interventions during interim analyses. The methods included centralized intervention packaging, randomization, data quality assessment, and data archiving. Blinded analysis of 9,274 video-recorded behavior tasks and 3,652 magnetic resonance images were evaluated. All tools and protocols are presented and could be adapted to preclinical assessment in other disease areas.
WITHDRAWN: Neutralization and immunoperoxidase to estimate the immunogenicity of recombinant human rotavirus VP6 structural protein in vitro after insertion of the antibodies into cells using electroporation
Authors: Kamel Marwa A. , Shokeer Abeer , Hegazy Usama M. , El-Hakim Amr E. , Elsayed Omar EL-Farouk Rabia , Barakat Ahmed , Mohamed Aly F. , Hamza Ibrahim Ahmed , Fuentes Cristina , Pinto Rosa M. , Bosch Albert , El-Senousy Waled Morsy
Published: January 2025

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Analysis and automatic detection of lava flows using SAR backscatter applied to the 2017 eruption of Erta 'Ale Volcano, Ethiopia
Authors: Gosling Jemima , Dualeh Edna Warsame , Biggs Juliet
Published: January 2025

Mapping lava flows from a range of conditions and environments is critical for understanding flow behaviour and hazard assessment, but ground-based observations can be challenging especially in remote regions. Here, we use 39 SAR backscatter images from the COSMO-SkyMed satellite to measure the extent and surface properties of lava flows from the 2017-2019 eruption of Erta ‘Ale volcano, Ethiopia. Using pairs of images, we map the flow outlines and observe both increases and decreases in backscatter which we attribute to differences in surface roughness. We apply a sequential analysis technique, CUSUM, and find that it can automatically identify flows from the background with 0.88 efficiency. However, simple lava flow simulations (Q-LavHA) could not reproduce flow extents with reasonable input parameters, highlighting the lack of appropriate calibrations. This stresses the importance of thorough volcanic observations and measurements to correctly determine lava flow parameters for use in volcanic modelling and hazard assessments.
Role of CXCL12/CXCR4 pathway and miRNA expression profiles on polymorphonuclear mobilization in COVID-19 patients
Authors: Daniel Matthieu , Bernardin Faustine , Sennsfelder Laetitia , Payet Melissa , Vagner Damien , Kantor Elie , Weisse Flore , Verhille Juliette , Fernandes Elisabeth , Guihard Bertrand , Doray Bérénice , Bedoui Yosra , Raffray Loïc , Gasque Philippe
Published: January 2025

Introduction:
Polymorphonuclear neutrophils (PMN) are actively recruited during COVID-19 and yet dysfunctions are associated with its prognosis. The PMN receptor CXCR4 and its ligand SDF-1/CXCL12 are known to play a role in the recruitment of PMN. The primary objective was to evaluate the modulation of this pathway in COVID-19 patients and after treatment with dexamethasone (DXM). Secondary objectives were to evaluate miRNA expression profiles.
Material and Methods
We conducted a prospective study comparing patients admitted to the emergency department from December 2022 to April 2023 for SARS-CoV-2 infection with a control population. We studied the PMN surface expression of the CXCR4 receptor, circulating levels of SDF-1 and miR levels. Patients treated with dexamethasone (DXM) were sampled again at H48.
Results
Forty-four infected patients and 20 controls were analyzed. SDF-1 levels were significantly increased in COVID-19 patients and significantly decreased after treatment by DXM and CXCR4 + PMN percentages increased significantly. SDF-1 levels on admission were associated with the risk of mechanical ventilation. Levels of miR 15b-5p, miR 146a-5p, miR 155-5p and miR 30d-5p were significantly increased in COVID-19 patients. Levels of miR-hsa-122 on admission were found significantly associated with mortality and its variation with the need for mechanical ventilation.
Conclusions
Our study suggests a possible involvement of the SDF-1/CXCR4 axis in the physiopathogenesis of COVID-19.
Heart Failure Detection in Electrocardiograms Using Artificial Intelligence
Authors: Ranjbar Arian , Stenhede Elias , Ravn Jesper , Schirmer Henrik
Published: January 2025

The diagnosis of heart failure (HF) is resource-intensive, requiring specialized personnel and equipment, which often leads to severe underdiagnosis. This study proposes the use of a machine learning model to detect HF in Electrocardiograms (ECGs), a commonly used tool in most healthcare settings. HF is known to have limited validity in diagnosis codes, limiting the viability of direct application of supervised learning. However, we hypothesize that validating diagnosis with measured levels of circulating N-terminal proB-type natriuretic peptide (NT-proBNP), ameliorates the impact of label noise in a large dataset. We demonstrate the success of the labelling strategy by developing a neural network and prospectively validating it in a cohort comprising 43109 patients. The model significantly outperformed NT-proBNP in diagnostic accuracy (p = 7.5e-7), and is capable of detecting both HF with reduced ejection fraction (AUC=0.91) and preserved ejection fraction (AUC=0.68-0.89 depending on definition). To highlight the impact of underdiagnosis in evaluating the model, we conducted a small-scale retrospective clinical evaluation of the test set, including patients with ejection fraction >50% with no HF diagnosis and normal levels of NT-proBNP. In this subgroup, 24 out of the 30 patients with the highest model-predicted risk satisfied the diagnostic criteria for HFpEF. These combined findings demonstrate the model’s capability in finding HF independent of ejection fraction, and a potential for accessible diagnostics through AI-enhanced ECG analysis.
Nanoscale size effects in α-FAPbI3 evinced by large-scale ab initio simulations
Authors: Rothlisberger Ursula , Carnevali Virginia , Agosta Lorenzo , Slama Vladislav , Lempesis Nikolaos , Vezzosi Andrea
Published: January 2025

Formamidinium-lead-iodide (FAPbI3) has established itself as the state of the art for high solar-energy conversion efficiency in perovskite-based solar cells. FAPbI3 has a rich phase diagram, and it has been noted that long-range correlation between organic and lattice dipoles can influence phase transitions and, consequently, optoelectronic properties. In this regard, system size effects can play a crucial role for an appropriate theoretical description of FAPbI3. In this context, we perform a systematic study on the structural and electronic properties of the photoactive phase of FAPbI3 (α-FAPbI3) as a function of system size. Utilizing ab initio molecular dynamics at 300 K and first-principles calculations, we demonstrate that the selection of the computational system/setup must satisfy three criteria concurrently to ensure an accurate theoretical description: the (correct) value of the band gap, the extent (or the absence of) structural distortions, and the zeroing out of the total dipole moment. We demonstrate that the net dipole moment vanishes as the system size increases due to PbI6 octahedra distortions rather than due to FA+ rotations. Additionally, we show that thermal band gap fluctuations are predominantly correlated with octahedral tilting. The optimal agreement between simulation results and experimental properties for FAPbI3 is only achieved by system sizes approaching the nanoscale.
Association of XPD Genetic Variations with Prostate Cancer Risk: Consolidated Results from 31 case-control studies
Authors: Narimani Nima , Atarod Mohammad Mehdi , Khosravi-Mashizi Mehdi , Maleki Hadi , Farshid Saman , Dastgheib Seyed Alireza , Alijanpour Abolhasan , Barahman Maedeh , Rahmani Amirhossein , Aghasipour Maryam , Aghili Kazem , Neamatzadeh Hossein
Published: January 2025

Background
This study aims to perform a comprehensive meta-analysis of existing literature to elucidate the associations between genetic variations in the XPD gene and the risk of prostate cancer development.
Methods
A systematic search of multiple databases, including PubMed, Scopus, EMBASE, and CNKI, was executed up until January 1, 2025, to collect pertinent information. The search utilized relevant keywords and MeSH terms pertaining to prostate cancer and genetic factors. Inclusion criteria were established for original case-control, longitudinal, or cohort studies. Associations were assessed as odds ratios (ORs) with 95% confidence intervals (CIs) employing Comprehensive Meta-Analysis software.
Results
This review included 31 case-control studies featuring 11,632 prostate cancer cases and 14,661 healthy controls. The polymorphism rs13181 (Lys751Gln) was studied in 16 studies with 5,295 cases and 7,199 controls, rs1799793 (Asp312Asn) in 10 studies with 3,316 cases and 4,310 controls, and rs238406 (Arg156Arg) in five studies with 3,021 cases and 3,152 controls. Pooled analyses indicated a significant association between the XPD rs13181 polymorphism and prostate cancer risk across all genetic models assessed. However, both rs238406 and rs1799793 polymorphisms showed no overall association with prostate cancer risk. Subgroup analyses revealed a significant link between rs13181 and rs238406 polymorphisms and prostate cancer risk in Asian populations, with no such association found in Caucasian or African groups. Furthermore, rs1799793 did not show a significant association with prostate cancer when examined by ethnicity.
Conclusions
The analysis of polymorphisms XPD rs13181 and rs238406 shows that the rs13181 G allele is significantly associated with increased prostate cancer risk, particularly in the Asian population. The rs238406 polymorphism displays a marginal association in the overall population but significant risk among Asians. Conversely, the rs1799793 polymorphism does not show meaningful associations in any group. These findings indicate that genetic factors may influence prostate cancer risk, with varying associations across ethnicities.
A Rare Presentation of Intramedullary Spinal Neurosarcoidosis without Systemic Manifestations: A Case Report and Literature Review
Authors: Assi Anas , Awwad Habeeb , Khaled Zaina , Sultan Riman , Owienah Haneen , Abulihya Mohand , Sweileh Thaer , Fayad Safwan , Karim Khalil , Kharousha Abdalwahab , Hussein Sami
Published: January 2025

Background
Sarcoidosis is a systemic inflammatory disease of uncertain etiology characterized by the formation of noncaseating granulomas affecting multiple organ systems. While pulmonary and lymphatic involvement commonly occur and aid in diagnosis, central nervous system (CNS) involvement is rare, occurring in only 3–10% of cases. Intramedullary spinal neurosarcoidosis (NS) is extremely rare, accounting for less than 1% of all cases, and presents substantial diagnostic challenges due to its nonspecific clinical and radiological features, which can mimic a range of other spinal cord disorders. Unlike systemic sarcoidosis, NS may manifest mainly as a neurological condition without systemic symptoms, complicating its identification and management.
Case Presentation:
A 35-year-old male presented with progressive lower limb weakness and neuropathic pain. Initial imaging suggested a diagnosis of transverse myelitis, but further investigation and evaluation revealed an intramedullary lesion at the T6–T8 level. Surgical removal of the lesion was performed, and a biopsy was performed, confirming the diagnosis of intramedullary spinal NS. The patient subsequently started receiving corticosteroid therapy and long-term immunosuppression, which resulted in partial recovery.
Conclusion
This case demonstrates the challenges in detecting patients with intramedullary spinal NS, particularly in the absence of systemic symptoms. Advanced imaging, histopathological evaluation, and a multidisciplinary approach are essential for precise diagnosis and effective treatment. These findings emphasize the need for personalized therapeutic strategies when addressing such uncommon presentations and challenges, contributing to the expanding body of literature on intramedullary spinal NS.
Efficient Cell-centered Nodal Integral Method for Multi-dimensional Burgers’ Equations
Authors: Ahmed Nadeem , Bharti Ram Prakash , Singh Suneet
Published: January 2025

An efficient coarse-mesh nodal integral method (NIM), based on cell-centered variables and referred to as cell-centered NIM (CCNIM), is developed and applied for solving multi-dimensional, time-dependent, Burgers’ equations. Unlike traditional NIM, which utilizes surface-averaged variables as discrete unknowns, this innovative approach formulates the final expression of the numerical scheme using discrete unknowns represented by cell-centered or node-averaged variables. By relying on these cell centroids, the proposed CCNIM approach presents several advantages compared to traditional NIM. These include a simplified implementation process in terms of local coordinate systems, enhanced flexibility regarding the higher order of accuracy in time, straightforward formulation for higher-degree temporal derivatives, and offering a viable option for coupling with other physics. The multidimensional time-dependent Burgers’ problems with known analytical solutions are solved in order to validate the developed scheme. Furthermore, a detailed comparison between the proposed CCNIM approach and other traditional NIM schemes is conducted to showcase its effectiveness. The simplicity and robustness of the approach provide a strong foundation for its seamless extension to more complex fluid flow problems.
Genetic Analysis of Factor VIII Gene Polymorphisms in Indian Populations for Hemophilia A Carrier Screening
Authors: Hemaliya Chanda , Meena Lalit Prashant , Kumar Ajeet , Ali Akhtar , Singh Arun Kumar
Published: January 2025

Background
A deficiency of factor VIII (FVIII) and factor IX (FIX) causes hemophilia A (HA) and hemophilia B (HB), respectively. This X-linked recessive disorder involves mutations in the F8 gene at Xq28 for HA and at Xq27 for HB on the X chromosome. These disorders, which cause complications with coagulation and prolonged bleeding, primarily affect men. Hemophilia A is responsible for around 80% of all cases. The allele frequencies of three FVIII gene-linked markers—IVS7 nt 27 G/A SNP, Bcl-I/intron 18, and Hind-III/intron 19—were assessed using ARMS (amplification refractory mutation system) primers in 276 Indian women from unrelated families.
Objective
The most feasible way to find carriers in underdeveloped nations is to use indirect linkage analysis to discover a defective X chromosome.
Method
Using restriction fragment length polymorphism and polymerase chain reaction, 276 individuals from 203 families with male hemophilia A patients and 276 normal participants were enrolled in Sir Sunderlal Hospital Varanasi. The participants were evaluated for the intron 18 Bcl-I, intron 19 Hind-III, and IVS7 nt 27 SNP markers.
Results
The Bcl-I, Hind-III, and IVS7 genes were heterozygous in 54%, 39%, and 13% of the women under study, respectively. The IVS7 nt 27 "G"/"A" allele, Bcl-I "T"/"A" allele, and Hind-III "C"/"T" allele had corresponding allele frequencies of 0.87/0.13, 0.47/0.53, and 0.62/0.38 in healthy women. By utilizing the Bcl-I, Hind-III, and IVS7 markers, the informativeness of the families was 57%, 45%, and 16%, respectively. The combined informativeness of these polymorphic sites is 67%.
Conclusion
The present research shows that the IVS7-SNP, Bcl-I, and Hind-III markers can diagnose HA carriers in the Indian population.
Enhancing Practical Design Skills Using AI-Powered Graphic Design Platforms: A Pedagogical Framework for Beginner Learners.
Authors: Osei-Wusu Franco , Asante George , Yeboah Donald , Muntaka Siddique Abubakr , Sarfo Elvis Antwi , Azameti Charles Yao , Adotey Alexandra
Published: January 2025

The integration of artificial intelligence (AI) tools into graphic design education has gained attention as a means to simplify skill acquisition for beginners. Traditional graphic design tools often present steep learning curves, making it difficult for novice learners to acquire practical skills without extensive technical expertise. This paper proposes the IIH-AILP Model, a structured pedagogical framework designed to leverage AI-powered platforms such as Canva and Adobe Firefly to improve accessibility, inclusivity, and efficiency in graphic design education. The methodology employs a 12-week intervention with a mix of sequential and integrated components, including pre- and post-assessments, modular learning, skill progression, gamified engagement, and comparative evaluations. Participants’ design abilities were assessed across creativity, task completion time, and learning curve improvements using carefully designed evaluation metrics. The results demonstrate that the IIH-AILP model significantly reduces the learning curve, enhances creativity, and improves task efficiency, confirming the potential of AI-powered graphic design platforms to streamline education for beginners with little to no technical expertise.
Clareamento Dental Caseiro com Peróxido de Hidrogênio Eficácia, Efeitos Colaterais e Marcas Comerciais mais utilizadas: Revisão Integrativa de Literatura
Authors: Souza Gustavo Frederico Alves de , Silva Gabriela Cristina Melo , Vasconcelos Marcelo Gadelha , Vasconcelos Rodrigo Gadelha
Published: January 2025

Introdução: A busca pelo sorriso ideal, alinhados, brilhantes e cada vez mais brancos tem aumentado de maneira significativa, fazendo com que a procura por procedimentos estéticos, como o clareamento dental, seja bastante almejado para melhora no aspecto do sorriso nas últimas décadas. Objetivo: Apresentar, por meio de uma revisão integrativa da literatura, os principais resultados sobre a eficácia, os efeitos colaterais e limitações do clareamento dental caseiro, após o tratamento a base do peróxido de hidrogênio, além de fazer uma análise comparativa dos protocolos com as diferentes concentrações, bem como verificar quais são as marcas comerciais mais utilizadas. Metodologia: Para a realização deste estudo em questão, a coleta de dados e informações foram realizadas nas bases de dados eletrônicos: PubMED, LILACS e SciELO. Além disso, os estudos selecionados foram publicados a partir de 2017 até 2023. Para a revisão bibliográfica em questão, foram incluídos estudos experimentais, ensaios clínicos e revisões de literatura e não houve restrição quanto ao idioma. Resultados: O estudo analisado e revisado, de acordo com a literatura, apresentou resultados satisfatórios com o clareamento dental caseiro a base de peróxido de hidrogênio, independente das suas concentrações que são 6%, 7,5% e 10%, esses géis clareadores por ter menores concentrações apresentaram um tratamento mais longo, em detrimento PH 35%. Além disso, os géis de menores concentrações apresentaram menor sensibilidade. Conclusão: O clareamento dental caseiro, por ser um procedimento menos invasivo e apresentar resultados estéticos eficazes mesmo que não imediato devido às suas concentrações mais baixas em relação ao clareamento de consultório, o clareamento dental caseiro, a base do peróxido de hidrogênio, tem sido muito utilizado, devido à sua facilidade em seguir os protocolos recomendados em casa e o nível de sensibilidade e dor do paciente aparentemente ser menor. No entanto, o procedimento ainda requer estudos mais detalhados visando à diminuição da sensibilidade a qual acontece após o clareamento, seja ele o caseiro ou de consultório, para que o paciente consiga seguir os protocolos recomendados da melhor maneira possível sem recorrência da sensibilidade durante e após o procedimento.
HIGHLIGHTING QUALITY TOOLS FOR EFFICIENT SOLID WASTE MANAGEMENT IN CONAKRY
Authors:   Higher Institute of Educational Sciences of Guinea, Department of Training of Middle and High School Teachers in Human and Social Sciences (PCL/SHS), Geography-Economics Section., Kaba Traore Maningbe , Konate Daouda ,   Higher Institute of Veterinary Sciences and Medicine of Dalaba, Department of Fisheries and Aquaculture.
Published: January 2025

This study addresses the problem of the management of urban services in charge of solid waste management in African cities and particularly focuses on the role of quality management in solving the problems of solid waste management in Conakry. The hypothesis is that the absence of a quality management system contributes to unsanitary problems. The objective of this study aims to propose an adapted solid waste management model for Conakry. The results obtained following the empirical research method (observation, documentary exploitation and semi-structured interview), are aligned with other research on an African and global scale suggest solutions for better urban environmental governance. Indeed, a new management model, the MKT-LIMSO (Maningbe Kaba TRAORE-Integrated Strategic and Operational Management Logigram), has been proposed, integrating various tools for more effective management. The recommendations include continued research on waste flows, strengthening environmental education, integrating new public management, training actors in the solid waste sector, and promoting innovation towards an economic circular. The establishment of taxes, standards and the sharing of management between municipalities are also proposed to improve the situation.
Estado liberal y Estado totalitario
Authors: Muriel Alexander
Published: January 2025

La idea marcuseana de que en el seno de la sociedad liberal se va preparando lenta y paulatinamente la concepción totalitaria y, por consiguiente, el estado totalitario sirve de pretexto para unas reflexiones sobre la responsabilidad de dicha sociedad en la complejidad de la guerra. Efectivamente, si de algo decía estar seguro Marcuse había sido que el estado fascista era la sociedad fascista (cf. 1967, 7), y este orden de cosas se había gestado en el seno mismo de la sociedad liberal. Yendo un poco más allá, sostengo que el totalitarismo es fase superior del estado liberal como recurso extremo para defender la propiedad y la explotación intensiva de los recursos dónde estén, ya sea en la proximidad del espacio vital (lebensraum) o más allá. De ahí que el estado liberal sea la guerra, aunque exporte la idea de defender de ella a la sociedad misma, pero a la que recurre necesariamente, soterradamente, inexorablemente.Realizaré inicialmente, una excursión por aquello que expone Marcuse en un texto de cierta consideración, titulado La lucha contra el liberalismo en la concepción totalitaria del Estado; expondré, a renglón seguido algunas reflexiones combinadas, fruto de esta lectura de Marcuse y mis ideas expuestas en la tesis doctoral, a propósito de la guerra y el estado y el desarrollo de la racionalidad bélica en la modernidad.
Latin American Critical Social Sciences and Situated Thinking
Authors: Pachón Soto Damián
Published: January 2025

The article highlights the dangers of conducting research without being aware of the place of enunciation. It reviews the deformation of the American reality by European science in the 17th and 18th centuries. Subsequently, it illustrates with examples the attempts to overcome this problem in the American eighteenth century, a period that gave rise to a marked interest in investigating the American reality, an endeavor that reached its climax with the emergence of the so-called Social Sciences in the mid-twentieth century. Finally, we reflect on some of the implications of situated and localized thinking. René Zavaleta’s concept of variegation is used for this purpose. It is found that thinking and researching situationally, by attending to specific contexts, avoids losing sight of the heterogeneity and complexity of situated realities. It is something that can also contribute to create emancipatory possibilities.
Sistema electoral y de partidos: un análisis de la Constitución de 1991 y sus reformas
Authors: Buriticá Arango Esteban David
Published: January 2025

Este artículo analiza los principales rasgos del sistema electoral creado por la Constitución Política de Colombia (1991) y las reformas de 2003, 2009 y 2015. Inicialmente, describe los efectos del régimen electoral previsto en la Constitución Política y sus reformas en la dispersión de los partidos en el Congreso de la República durante las elecciones legislativas de 1994 a 2022. Luego, se analiza la evolución de la normativa constitucional y legal sobre los fenómenos del transfuguismo y la doble militancia desde 1991, así como los efectos de ambos fenómenos en el sistema electoral y de partidos políticos. Y finalmente, analiza los problemas que afrontan las autoridades electorales para ejercer las funciones de control y vigilancia de las elecciones y los partidos políticos. El artículo cierra con un balance de los retos más importantes que debería afrontar una futura reforma.
Brains are Probabilistic, Electrophysiologically Intricate and Triune: A BiasedRandom Walk Perspective on Computational Neuroscience
Authors: Gomez-Molina Juan Fernando
Published: January 2025

The pursuit of a unified theory that captures the intricacies of the brain and mind continues to be a significant challenge in theoretical neuroscience. This paper presents a novel, triune framework that utilizes the concept of collective biased random walk (cBRW). Our approach strives to transcend biological specifics, offering a high-level abstraction that remains general and applicable across various neural phenomena. Despite the solid traditional foundation of computational neuroscience, the intricate delicacy of neural processes calls for a renewed probabilistic approach. We aim to utilize the intuitive nature of probability concepts —such as the probability of localization and state, and uniform probability distribution— to study the stochastic organization of electric charges and signals in the brain. This electrophysiological intricacy emerges from the seemingly paradoxical reality that tiny electric events, while random, collectively give rise to predictable, long-range oscillations. These oscillations manifest in three groups of activation states. Our framework categorizes the brain as a triune system, accommodating classical, semiclassical, and non-classical interpretations of both probabilistic phenomena and cBRW models, alongside three groups of states. We conclude that by appreciating, rather than overlooking, the tiny random walks of electric charges and signals in the brain, we can gain a triune mathematical foundation for theoretical brain science, the powerful capabilities of this organ, and the electromagnetic interfaces we can develop.
Inteligencia artificial generativa: análisis bibliométrico de su impacto en la sociedad y sus consideraciones para el mundo empresarial
Authors: Osorio Andrade Carlos Fernando , Arango Espinal Edwin , Loaiza Gallego Johanna Andrea
Published: January 2025

Se evaluó el estado de la investigación científica que relaciona al campo de la inteligencia artificial generativa con el área del management. Mediante un análisis bibliométrico, se revisaron 133 artículos científicos indexados en Scopus entre 2020 y 2023. Indicadores descriptivos, análisis cualitativo de textos y un diagrama de red social, permitieron resumir la literatura científica para el campo de estudio. Se identificaron nueve corrientes de investigación: inteligencia artificial en educación; ChatGPT como tecnología disruptiva; impactos generales de ChatGPT; ChatGPT auto concepto y bienestar; ChatGPT e investigación académica; ChatGPT en gestión de organizaciones; ChatGPT en gestión de la cadena de suministro; ChatGPT en turismo y hospitalidad y aspectos éticos de ChatGPT.
Encrucijada en la agenda global 2020-2024: entre cooperación para el desarrollo mundial y la ayuda militar a Ucrania
Authors: Prado Lallende Juan Pablo
Published: January 2025

De enero del 2020 a diciembre de 2024, la pandemia generada por el COVID-19, la intervención rusa en Ucrania, la guerra israelí en Gaza a causa de los atentados de Hamás y los ataques a Líbano en contra de Hezbolá, junto con un ramillete de adversos sucesos, afectaron de manera determinante la agenda global del desarrollo y, en consecuencia, a los Objetivos de Desarrollo Sostenible (ODS). Durante este cuatrienio, como ha ocurrido en épocas pasadas, y conforme lo establecen las premisas realistas de las Relaciones Internacionales, los criterios geopolíticos y militares predominan en la conducción de asuntos mundiales. Frente a ello, cabe preguntar cuál es el estado de la agenda global del desarrollo del 2020 al 2024 y, en este sentido, cuáles son las directrices generales de la cooperación internacional frente al presente convulso estado mundial, en particular de cara a la pandemia a causa del COVID-19 y a la securitización del entorno internacional y los efectos más significativos de estos y otros sucesos respecto a los ODS. Para responder a esta pregunta de investigación, este artículo tiene el objetivo de analizar los elementos más significativos de los cuales depende la agenda global del desarrollo durante el cuatrienio 2020-2024, en donde sobresalen los ODS, cuyo estado actual, conforme lo señala Naciones Unidas, no es alentador.
La hipótesis que guía la investigación argumenta que, si bien la pandemia se extinguió, y con ello se avizoró un contexto propenso a favor de causas mundiales, la agenda global del desarrollo del año 2020 al 2024 se encuentra inmersa en una encrucijada, debido a los efectos del COVID-19, a la guerra en Ucrania y la ingente ayuda militar a Kiev y, de forma más actual, la Crispación en Oriente Próximo a causa de los enfrentamientos en Gaza y Líbano. Estos factores debilitan a la cooperación internacional necesaria para promover propósitos globales, donde el estado actual de los ODS es preocupantes e, incluso, en algunos casos registra regresiones.
Lugar de enunciación de Djamila Ribeiro
Authors: Romero López Laura
Published: January 2025

La obra de Djamila Ribeiro debe ser entendida como una obra esencial para el estudio de los feminismos otros. La filósofa, escritora y activista, logra con este primer número de su Colección, esencialmente, explicar en lenguaje asequible y con gran rigor académico una de las herramientas más interesantes para la creación de debates más sanos.