bluuebunny/crossref_metadata_2025 huggingface dataset:
Action de l’acide 13-cis-rétinoïque et du rétinoïde aromatique sur divers paramètres cutanés, chez le rat rendu hyperséborrhéique
Authors: Garigue J. , Navarro Ch. , Roux G. , de Graeve Ph. , Lagorce Ch. , Bazex J.
Published: October 2009

Castrated rats submitted to androgenic stimulation present hyperseborrhea with an increase in foamy cells associated with an increase in cutaneous lipids and a change in the number of epidermal cell layers. 13-cis-retinoic acid and aromatic retinoid (Ro 10-9359) were given orally during 17 days (10 mg/kg) to castrated rats which had received a testosterone implant. Cyproterone acetate was chosen as the antiandrogenic drug; it was given at doses of 10 mg/kg i.m. once every other day. As opposed to cyproterone acetate, the two substances studied had no effect on the seminal vesicle and ventral prostate. 13-cis-retinoic acid and retinoic aromatic acid incressed the total number of epidermal layers: In the case of 13-cis-retinoic acid, the increase involves especially the nonnucleated cell layers, whereas with retinoid aromatic acid it involves the nucleated cell layer. The number of sebaceous glands is not changed by either products, on the other hand, the number of foamy cells is considerably decreased and the weight of cutaneous lipids is decreased as well.
Effect of Oral Retinoid Treatment on Human Natural Killer Cell Activity
Authors: Jansén Christer T. , Viander Markku , Koulu Leena
Published: October 2009

Peripheral blood natural killer (NK) cell activity was screened in patients with non-malignant disorders of the skin who took oral etretinate or 13-cis-retinoic acid for up to 11 months. Compared to pretreatment values, the basic NK activity rose during the first 2 months of treatment, but thereafter returned to starting values. Interferon reactivity (IFN-α, IFN-γ) was essentially unaltered by the treatment. It is concluded that moderate oral retinoid doses cause a mild, transient stimulation of this natural immune surveillance system in man.
Electron Microscopic Demonstration of Virus Particles in Hand, Foot and Mouth Disease
Authors: Haneke Eckart
Published: October 2009

Early skin and oral mucous membrane lesions of hand, foot and mouth disease (HFMD) were biopsied and investigated by light and electron microscopy. Histology showed spongiosis, intraepidermal splits indicating beginning vesicle formation, exocytosis of lymphoid cells and macrophages, and individual necrotic keratinocytes. Electron microscopy revealed naked viruses with a mean diameter of 24 nm which were arranged in sheets in the cytoplasm. Many keratinocyte nuclei contained tonofibrils. Cellular injury ranged from slight cytoplasmic edema to keratinocyte necrosis. Some nuclei showed dissolution of the nuclear membrane and dislocation of cytoplasm into the nucleus.
Metastatic Breast Carcinoma on the Lip: Case Report
Authors: Cotton D.W.K. , Fairris G.M.
Published: October 2009

A case of breast carcinoma metastatic to the lip is reported. The lesion presented clinically as a kerato-acanthoma and histologically as a sweat gland tumour. Immunoperoxidase studies revealed its breast origin.
Eczéma séborrhéique et psoriasis chez le nourrisson: étude comparative morphologique et cinétique
Authors: Heenen M. , Song M. , Achten G.
Published: October 2009

Seborrhoeic dermatitis, psoriasis and atopic dermatitis in infants were studied morphologically and autoradiographically on skin biopsies. A similar picture with an increased germinative cell population and accelerated cell turnover has been found in psoriasis and seborrhoeic dermatitis. These features may suggest a relationship between both diseases.
Influence of the Diet on the Plasma Kinetics of 8-Methoxypsoralen
Authors: Bonnot D. , Beani J.C. , Beriel H. , Boitard M. , Amblard P. , Reymond J.L.
Published: October 2009

The plasma kinetics of 8-methoxypsoralen (8-MOP) have been determined in 103 patients treated by PUVA in the routine conditions in which PUVA therapy is carried out in hospital. 8-MOP is taken with breakfast; four types of breakfast were available, which differed by their lipid content; this study showed that the diet has no influence on the bioavailability of 8-MOP.
Photoprotective Effect of Topical Indomethacin – An Experimental Study
Authors: Schwarz Thomas , Gschnait Fritz , Greiter Franz
Published: October 2009

Indomethacin applied after an erythematogenic dose of UVB light suppresses the development of erythema by inhibition of prostaglandin synthesis. In this study indomethacin was tested prior to UV exposure in humans in vivo and was shown to be a potent UVB and UVA filter. Indomethacin thus represents the first topical agent known to prevent and treat sunburn simultaneously. A 2.5% indomethacin solution was applied on test areas 1 h before UVB irradiation. Indomethacin-pretreated skin tolerated 4.3 times more UVB light and indomethacin-protected skin developed significantly less sunburn cells than untreated areas. In order to study its possible UVA screening capacity test areas were irradiated with 2, 4, 6, 8, 10 J/cm2 UVA light (PUVA) after ingestion of 8-methoxypsoralen. Indome-thacin-pretrated skin tolerated 2.2 times more UVA than untreated test areas. Immediate pigment darkening induced by UVA doses up to 25 J/cm2 was less pronounced in indomethacin-pretreated skin. To investigate the mode of action of the photoprotective effect observed skin was irradiated with erythematous doses of UVB light transmitted through a quartz glass layer coated with the indomethacin solution. The skin developed no erythema thus indicating that the effect of indomethacin when applied before irradiation is based upon photoabsorption and not upon inhibition of prostaglandin synthesis. This is also confirmed by the fact that the development of sunburn cells can be prevented only when indomethacin is applied before and not after irradiation.
Clonal Heterogeneity in a Case of Merkel Cell Carcinoma Demonstrated by Flow Cytometry
Authors: Deinlein Edgar , Gassenmaier Antoinette , Haneke Eckart , Grässel-Pietrusky Rolf
Published: October 2009

A 66-year-old female patient is presented in whom a rapidly growing tumour developed on the glabella. Light and electron microscopy confirmed Merkel cell carcinoma. Flow cytometry (FCM), performed of a tumour specimen, yielded multiple aneuploid stem lines. The FCM data are discussed with regard to the histological features and the biological behaviour of the tumour.
Sebum Suppression by Benzoylperoxide
Authors: Schmidt J.B. , Neumann R. , Knobler R. , Spona J.
Published: October 2009

Sebum excretion rate (SER) was determined by thin-layer chromatography and based on densitometric data in 9 male and 5 female patients suffering from acne during treatment with 10% benzoylperoxide (BPO). BPO was applied to the forehead (treatment area), whereas gel only was applied to the chest (control area) for 6 weeks. SER decreased in 10/14 subjects, no change was found in 1 subject and 3 patients exhibited an increase in SER. Suppression varied between 12 and 86%. Concomitant SER reduction in control and treatment areas was noted in 6 patients. When treatment and control areas of individual patients were considered for data evaluation, SER decrease was noted in only 4 out of 14 subjects. Similar results were obtained when free fatty acids, triglycerides and squalene data were analyzed. Combined, these data suggest that BPO may affect SER in some patients. The present experiments indicate the importance of adequate controls in such studies.
Paget’s Disease of the Nipple
Authors: Ascensão A.C. , Marques M.S.J. , Capitão-Mor M.
Published: October 2009

The most relevant literature concerning Paget’s disease of the breast is reviewed. A clinical and pathological study of female patients with Paget’s disease of the breast observed during 30 years at the Lisbon ‘Institute Português de Oncologia’ is carried out and its results are discussed. The low incidence of the disease in this series, when compared with those described in the available literature, is pointed out. The absence of a relation between the type of the cutaneous lesions and the histological type of the underlying tumor is emphasized. The similarity of the microscopical aspects, whichever the histological type of the underlying tumor, is considered. The differences in the clinical behavior of the tumors, related to their histological types, and the differences in respect to age, menarch, menopause, breast feeding, primary lesion and percentage of adenopathies observed between patients with and without a palpable mass, are enumerated. The authors conclude that the cure rate after 5 years is lower in patients with palpable tumors and adenopathies and in the cases with onset before menopause. The cure rate also decreases in relation to the histological type of the underlying tumor.
Domoprednate (Stermonid®), a Topical D-Homocorticosteroid, Skin Atrophy and Telangiectasia
Authors: Serup Jørgen , Holm Per
Published: October 2009

Five corticosteroid ointments and placebo were compared in 17 volunteers with regard to their influence on normal skin under occlusive conditions. Each volunteer had six simultaneous applications on the forearms and six on the back. The trial was double-blind and lasted 4 weeks. The ointments were placed in randomized order. The treatments were 0.1 and 0.03% domoprednate, 0.1% hydrocortisone butyrate, 0.1% betamethasone valerate, 0.05% clobetasole propionate and placebo. Skin thickness was measured on days 0, 7, 14, 21 and 28, transepidermal water loss on days 0, 14 and 28, while blood flow and telangiectasias were evaluated only on day 28 at termination of the trial. The skin thickness became significantly reduced on all corticosteroids, but not on placebo; 0.03% domoprednate, however, tended to have an intermediate position between placebo and the other ointments. The transepidermal water loss did not change. Rating of telangiectasia under stereomicroscope showed a significantly lower score after 0.03% domoprednate and placebo as compared to the other ointments. Assessment of telangiectasia by laser-Doppler flowmetry showed a similar tendency. It is concluded that 0.1% domoprednate is comparable to other topical corticosteroids with respect to atrophogeneity and formation of telangiectasia, but the 0.03% concentration seems to result in fewer side effects.
The Treatment of Psoriasis with 0.1% Domoprednate (a D-Homocorticosteroid) and 0.1% Betamethasone Valerate Ointment
Authors: Christiansen J.V. , Foged E. , Holm P. , Jørgensen A.S. , Reymann F.
Published: October 2009

In 85 patients with psoriasis vulgaris the efficacy and tolerance of domoprednate and betamethasone valerate were studied in a double-blind, randomized trial lasting 4 weeks. Complete or satisfactory remission was obtained in 36% in the domoprednate group and in 53% in the betamethasone group. This difference is not statistically significant (p > 0.10). 3 patients on each treatment experienced some local irritation. No laboratory abnormalities were found during the study.
Demonstration of HPV-16 Genomes in the Nuclei of Cervix Carcinoma Cells
Authors: Grussendorf-Conen Elke-Ingrid , Ikenberg Hans , Gissmann Lutz
Published: October 2009

Specimens of 4 different cervical cancers, 1 flat condyloma of the cervix, 1 condyloma acuminatum, 1 morbus Bowen of the skin and 1 skin wart were subjected to in situ hybridization using human papilloma virus type 16 (HPV-16) DNA nick translated with 3H-TTP as a probe. Within each cervical cancer biopsy we found a certain number of tumor cell clusters with clearly labelled nuclei, while sections of the other skin lesions did not reveal any accumulation of grains within their nuclei. Southern blot hybridization of the DNA extracted from the 4 cervical carcinomas with 32p-labelled HPV-16 DNA gave a positive reaction in 3 tumors. Non-reactivity in the 4th biopsy might be due to a low concentration of HPV-genomes within the total extracted DNA of this tissue part.
Porocarcinome eccrine
Authors: Ruffieux C. , Ramelet A.-A.
Published: October 2009

Eccrine porocarcinoma is a rare malignant skin tumor arising from the epidermal sweat duct unit (acrosyringium). The report of 4 cases illustrates the clinical and histological characteristics. The prognosis of this carcinoma remains difficult to assess because of the lack of a catamnestic study.
Keratoacanthoma centrifugum marginatum versus Low-Grade Squamous Cell Carcinoma
Authors: Peteiro M.C. , Caeiro J.L. , Toribio J.
Published: October 2009

A case of keratoacanthoma centrifugum marginatum is reported. The case is characterized by its size and its association with epidermolysis bullosa dystrophica.
Placebo-Controlled Study of the Efficacy of Topical Antihistaminics against Histamine-Induced Pruritus
Authors: Milsmann E. , Rohdewald P.
Published: October 2009

2 antipruritic ointments, when compared to placebo, were ineffective against histamine-induced itching applied in 2 volunteers after the intracutaneous injection of histamine. Testing of 11 topical antihistaminics after pretreatment for 30 and 60 min on 12 volunteers showed that some of the preparations reduced the histamine-induced itching significantly, while others were able to inhibit itching only slightly or were very close to placebo. Pain from pin pricks could not be attenuated significantly by pretreatment with the topical antihistaminics at any time.
Unusual Pigmentation on the Skin over Trunk Bones and Extremities
Authors: Tanigaki Takehiko , Hata Seiichiro , Kitano Yukio , Nomura Masao , Sano Shigeharu , Endo Hidehiko , Tsuda Michio , Hashimoto Seiichi
Published: October 2009

6 young people (19–31 years old) exhibited unusual light or dark brown, ill-circumscribed or reticular pigmentation distributed over protrudent bones. 5 of them have been using nylon towels and scrub brushes for over 3–10 years. Biopsy specimens showed that the amount of melanin granules in the basal layer was increased and melanophages were scattered in the upper dermis. Inflammatory infiltrates were minimal.
Subcorneal Pustular Dermatosis and IgA Myeloma
Authors: Tio Raul Dal , Vito Francesco Di , Salvi Flavia
Published: October 2009

The authors describe a new case of subcorneal pustular dermatosis associated with IgA myeloma. The significance of this association is unknown, but it seems to be more than a coincidence. The case described is particular, because the interval between skin eruption and first symptoms of myeloma is very long (27 years), and palms and soles are involved.
Generalized Pustular Psoriasis in a Child
Authors: van de Kerkhof P.C.M.
Published: October 2009

We present the first report of the management of generalized pustular psoriasis (Zumbusch pattern) in a young child with etretinate (Tigason). Striking features were the low dosage required to control the disease (as little as 10 mg per week) and the eventual transition of the clinical features to those of psoriasis vulgaris.
Rougeole atypique
Authors: Dereume J.L. , Zechi F. , de Sélys R. , Bourlond A.
Published: October 2009

Atypical measles with high fever, pneumonitis, erythemato-papular and pustular rash occurred in a 16-year-old girl who had been vaccinated with the inactivated (killed) virus 15 years ago.
Pemphigus superficiel apparu lors du traitement d’une polyarthrite rhumatoïde par D-pénicillamine et piroxicam (Feldène®)
Authors: Piette-Brion B. , de Bast C. , Chamoun E. , de Dobbeleer G. , André J. , Huybrechts A. , Ledoux M. , Achten G.
Published: October 2009

The authors report a new case of induced pemphigus: a 64-year-old man has had rheumatoid arthritis for 10 years. When he developed his pemphigus, he had been taking D-penicillamine and piroxicam for about 8 months. He needed high doses of prednisolone associated with azathioprine to clear his eruption. The case had a fatal outcome.
The Problem of the Sensitization to Dithiocarbamates in Thiuram-Allergic Patients
Authors: van Ketel W.G. , van den Berg W.H.H.W.
Published: October 2009

Because of the occurrence of hand dermatitis in members of a surgical staff due to allergy to thiuram-containing rubber gloves, an investigation was performed about cross-sensitization between thiuram compounds and dithiocarbamates. Positive reactions to dithiocarbamates were compared with reactions to 8 brands of hypo-allergenic or dithiocarbamate-containing surgical gloves. There appeared to be a marked difference in reactions to the dithiocarbamate-containing gloves. Some brands gave negative or nearly always negative reactions, while other brands caused many positive reactions. Thiuram-allergic patients were advised to wear nonreacting rubber gloves or PVC gloves.
Toxic Epidermal Necrolysis Probably Due to Klebsiella pneumoniae Sepsis
Authors: de Groot Ronald , Oranje Arnold P. , Vuzevski Vojislav D. , Mettau Jan W.
Published: October 2009

We describe a case of toxic epidermal necrolysis probably caused by Klebsiella pneumoniae septicaemia. The clinical and histological findings of this patient were typical for toxic epidermal necrolysis.
A Case of Hypothyroidism with Bulla Formation
Authors: Mochizuki T. , Tanaka S. , Watanabe S.
Published: October 2009

Intraepidermal blisters caused by slight abrasion appeared on the fingertips, toes and insteps of the feet of a 73-year-old Japanese female suffering from primary hypothyroidism. The tendency to form bullae decreased markedly with the administration of thyroid hormone. The discussion concerns the relation between bullae and thyroid hormone level.
Malignant Hidroacanthoma simplex
Authors: Moreno A. , Salvatella N. , Guix M. , Llistosella E. , de Moragas J.M.
Published: October 2009

2 cases of malignant hidroacanthoma simplex are reported. Prominent ultrastructural findings were sparse tonofilaments and villous-like, interdigitating cytoplasmic processes connected by small desmosomes. Positive intracytoplasmic stain for carcinoembryonic antigen was found in 1 case. Benign and malignant eccrine poromas and hidroacanthoma simplex appear to be related neoplasms on the basis of ultrastructural and immunohistochemical findings.
Erythema multiforme – Response to Corticosteroid
Authors: Ting H.C. , Adam B.A.
Published: October 2009

We studied the response to treatment in 25 patients with erythema multiforme minor, 13 of whom were given corticosteroid while 12 were not. Apart from a shorter duration of fever, the steroid-treated group did not respond better than the non-steroid treated group.
Patient Noncompliance in Dermatomycosis
Authors: Meinhof W. , Girardi R.M. , Stracke A.
Published: October 2009

Noncompliance among dermatomycosis patients exists in many forms and is widespread. Patients are noncompliant in two major areas: they reduce the number of necessary daily applications of the antifungal drug and they prematurely stop the therapy. A survey among 35 dermatologists and general practitioners as well as 230 dermatomycosis patients in Germany in 1982 showed that noncompliance is widespread: a total of 48% of patients neglected the proper daily dosage schedule, 44% reduced the number of daily applications, whereas 4% increased them. 25% of patients stopped treatment after the symptoms had disappeared. However, there is no such thing like the noncompliant patients personality. Depending on the kind of noncompliance, different personality structures appear. And based on the patient’s overall attitude towards noncompliance – one third confesses to be noncompliant – the psychological picture becomes even more complex and multifaceted. Improving patient compliance seems to be most promising by better, i.e. more thorough, doctor-patient communication and antifungal drugs that minimize the risks of noncompliant behavior by requiring less daily applications and a shorter time of treatment.
The Pros and Cons of an Oral Treatment of Dermatomycosis
Authors: Fredriksson T.
Published: October 2009

The advantages and disadvantages of oral treatment of dermatomycosis is discussed, particularly with regard to griseofulvin and ketoconazole as examples. The advantages versus topical treatment are better efficacy, better compliance, and oral treatment is possibly more economical. Disadvantages are toxicity, development of resistant strains, interaction with other drugs and time- and cost consuming regular supervision of the patients.
Bifonazole – A Synopsis of Clinical Trials Worldwide
Authors: Stettendorf S.
Published: October 2009

A synopsis is given on the results of 97 clinical trials of efficacy and tolerability involving a total of 3,443 patients in more than 20 countries all over the world. They were carried out with bifonazole cream 1%, solution 1%, gel 1% and powder 1%. 49% of the patients treated suffered from dermatophytosis, 30% from cutaneous candidosis and 21 % from pityriasis versicolor. The therapeutic efficacy and the tolerability proved good for the indications studied when administered once daily for a treatment period of 2 or 3 weeks.
Mycosis fongoïde et gammapathie monoclonale
Authors: Ruffieux C. , Stalder M. , Tran-Thang C.
Published: October 2009

We report the case of a patient suffering from mycosis fungoides and plasma cell myeloma. It is postulated that this is not a fortuitous association, but that the B cell neoplasm evolved under the sustained inducer stimulus of the malignant T lymphocytes. This hypothesis is suggested by the demonstration of the helper phenotype of the cutaneous lymphocytes associated with a predominance of helper lymphocytes in blood.
Pediculid
Authors: Brenner S. , Ophir J. , Krakowski A.
Published: October 2009

We describe a pruritic rash that appears to be associated with pediculosis capitis. We suggest calling it ‘pediculid’ since it appears to be an -id reaction to pediculosis capitis.
Pyoderma gangrenosum Associated with Selective Hereditary IgA Deficiency
Authors: Bundino Silvana , Zina Alberto Maria
Published: October 2009

A case of pyoderma gangrenosum is described in a girl aged 4. The condition was associated with selective IgA deficiency. The father and the 2 brothers suffered from the same deficiency (autosomal dominant transmission). Treatment with prednisolone and clofazimine produced an excellent clinical response.
Ongles grésés et «twenty-nail dystrophy of childhood»
Authors: Jeanmougin M. , Civatte J.
Published: October 2009

2 apparently idiopathic cases of twenty-nail dystrophy of childhood are reported with follow-ups of 4 and 16 years, respectively. The associated koilonychia appears to be only fortuitous and related to the fragility of the nail. Trachyonychia should be considered as a symptom often related to external traumatism or dermatoses, particularly alopecia areata or lichen planus, of which it could be a specific isolated location. Within the spectrum of apparently idiopathic trachyonychies, the twenty-nail dystrophy of childhood appears to be a real entity on the basis of its clinical features and course.
‘Onycholemmal’ Horn
Authors: Haneke E.
Published: October 2009

A lesion clinically and histologically mimicking trichilemmal horn was observed in the nail apparatus of a 62-year-old woman. The term ‘onycholemmal horn’ is proposed for this lesion.
Familial Continual Skin Peeling
Authors: Abdel-Hafez K. , Safer A.M. , Selim M.M. , Rehak A.
Published: October 2009

A clinical picture of familial continual peeling of the skin is described and discussed together with light and ultramicroscopic manifestations in one of the probands. The pattern of splitting distinguishes this condition from keratolysis exfoliativa. The ultramicroscopy exhibited mainly predominance of low-density keratocytes in the corneal layer, abnormalities in distribution of lamellar granules and disrupted coating of the cells in the intercellular spaces of the corneal layer.
Elastosis perforans serpiginosa
Authors: Ayala F. , Donofrio P.
Published: October 2009

Two brothers with typical, symmetrical lesions of elastosis perforans serpiginosa are presented. Familial occurrence has been reported only once. In neither family was the disease associated with heritable disorders of the connective tissue. The pedigree analysis suggests an autosomal-recessive pattern of inheritance.
Lupus tumidus Involving Facial Skin, Nasal Cavity, Throat and Eye
Authors: Ihm Chull Wan , Choi Chang Ki , Suh Jae Il
Published: October 2009

A case of tuberculosis involving facial skin, nasal cavity, throat and eyes was found in a young Korean girl. We report the case because of its unusual clinical picture and to recall the morbidity of cutaneous tuberculosis in the present dermatological field.
A Double-Blind Cross-Over Study of the Effect of Ketotifen in Urticaria pigmentosa
Authors: Czarnetzki Beate M.
Published: October 2009

10 adult patients with symptomatic urticaria pigmentosa were treated with ketotifen versus placebo in a double-blind cross-over study. A highly significant reduction of the daily symptom scores for pruritus and whealing was found with 2 mg ketotifen daily per os, and, compared to oral disodium cromoglycate, ketotifen was much more effective. Tiredness was the only side effect noted in 40% of the patients, and a transient worsening of symptoms was noted after discontinuation of the drug.
IgE and Immune Complexes in the Serum of Patients with Urticaria and Urticarial Vasculitis
Authors: Damseaux M. , Pierard-Franchimont C. , Pierard G.E.
Published: October 2009

IgE and immune complexes were searched in patients suffering from urticaria and urticarial vasculitis. Increased amounts of IgE and increased C1q binding activity in the serum were often found, but practically never in association. Type I and III immune reactions do not seem to coexist at the same time to induce urticarial lesions.
Age-Related Severity of Male-Pattern Alopecia
Authors: Cervia M. , Rebora A.
Published: October 2009

The severity of the male-pattern alopecia according to the age of the patient has been studied in 302 subjects, and conventionally scored. The scores revealed a linear regression with age. In 81 more subjects, all beyond 70 years of age, the disease does not seem to have developed any further.
A Case of Cellulitis generalisata
Authors: Langeland J.
Published: October 2009

A case of generalized cellulitis is described. It is suggested that it represents an extreme variation of a physiological phenomenon.
Serum Vitamin A Levels and Pruritus in Patients on Hemodialysis
Authors: de Kroes Saskia , Smeenk G.
Published: October 2009

35 patients attending a hospital dialysis unit were questioned for the presence and severity of pruritus. Attention was given to skin anomalies and loss of hair. In all patients the serum vitamin A level was determined. Although all of them showed an increased serum vitamin A level, no correlation could be found between the vitamin A content and the presence of pruritus.
Crateriform Depression – An Unusual Clinical Expression of Pitted Keratolysis
Authors: Sehgal V.N. , Ramesh V.
Published: October 2009

An unusual presentation of pitted keratolysis in the form of crateriform depressions is reported. The probable etiology of the condition is outlined.
Angiosarcoma of the Scalp-Face
Authors: Leoni A. , Cogo R. , Visonà A.
Published: October 2009

A case of scalp-face angiosarcoma with a fulminating 3 months shorter course is reported. The patient died of bilateral pleural bleeding secondary to hemorrhagic lesions of the visceral pleurae. Clinical findings and histopathology are reported and a brief review of the literature is made.
Tricho-Rhino-Phalangeal Syndrome
Authors: van Neste D. , Dumortier M.
Published: October 2009

A case of tricho-rhino-phalangeal syndrome is reported. Abnormally thin hairs were present on the scalp of this patient. Microscopic measurements of scalp hair bulbs disclosed a relative hypoplasia of the dermal papilla which was inserted into a well-developed hair matrix. These findings illustrate that a dermal defect may significantly modulate epithelial differentiation.
Numeration of T Cell Subsets in Sarcoidosis Using Monoclonal Antibodies: Decreased Levels of Peripheral Blood T Cells and Cells with Suppressor T Cell Phenotype
Authors: Faure Michel , Nicolas Jean-Francois , Gaucherand Martine , Czernielewski Janusz , Mauduit Gilles , Thivolet Jean
Published: October 2009

Peripheral blood lymphocytes from 16 patients with sarcoidosis (9 patients with skin sarcoids, 7 patients with erythema nodosum and bilateral hilar adenopathy) and cutaneous anergy and from 23 age-matched healthy controls were characterized by reactivity with monoclonal antibodies OK.T3, OKT4, OKT8 directed to surface antigens of T lymphocytes, helper-inducer and suppressor-cytotoxic Tcell subsets, respectively. In contrast to healthy controls, patients with sarcoidosis had reduced percentages of OKT3+, OKT4+ and OKT8 +cells and a major decrease in the OKT8 + (suppressor) subset. However, these changes were significant only in the group of patients with acute sarcoidosis (erythema nodosum). This abnormal T cell distribution correlates with the alterations in cell-mediated immunity previously observed and suggests the presence of a defective circulating suppressor T cell activity in acute sarcoidosis.
Effects of Etretinate (Ro 10-9359) on Darier’s Disease
Authors: Löwhagen Gun-Britt , Michaëlsson Gerd , Mobacken Håkan , Pettersson Ulf , Vahlquist Anders
Published: October 2009

The effect of the aromatic retinoid, etretinate, has been evaluated in 17 patients suffering from moderate to severe Darier’s disease (DD). The erythema, hyperkeratosis and number of papules as well as the extension of the lesions were scored before and at regular intervals during treatment. In the first treatment period a daily dose of 50 mg was given until healing but no longer than 10 weeks. In the majority of patients the effect was very good with almost complete clearing in 6 patients. In patients with severe DD a reduction of the initial score by more than 50% was seen in 7 out of 8 patients. Isomorphic reactions developed in 6 of 17 patients and was the most important side effect. In patients with moderate disease the remission periods without treatment exceeded 4 weeks. 8 patients were treated intermittently with a lower dose up to 4 treatment periods. Equally good results were obtained. The treatment of choice in DD seems to be etretinate at an intermittent regime with low doses (< 0.5 mg/kg).
Die Tumoren der Fusssohlen und Handinnenflächen
Authors: Rupec M. , Kint A. , Batzenschlager I. , Geerts M.L.
Published: October 2009

The tumors of the palms and soles removed between 1965 and 1979 in the Dermatology Departments in Ghent and Marburg are reported. These make up a total of 147 tumors. The attention is focussed on the nevuscell naevi (77), on one melanosis circumscripta precancerosa of the sole, on one pseudoangiosarcoma of the sole, on one benign synovialoma of the palm, on one epidermal cyst of the sole, on an acquired digital fibrokeratoma, on an acral arteriovenous tumor of the sole, on two Bowen diseases (of the palm and sole) and on two basal cell epitheliomas (of the palm and sole).
Preclinical Evaluation of Acid Products for Treatment of Solid Experimental Skin Tumors in Mice
Authors: Kreis W.
Published: October 2009

The effect of nitric acid preparations on five different solid experimental tumors in mice was studied. None of these highly malignant tumors was eradicated by any of the acid preparations studied, although differences in reactivity were noted between preparations in some models.
Histopathologic and Electron Microscopic Studies of the Effects of Solcoderm on Normal Epidermis and Superficial Cutaneous Tumors
Authors: Césarini Jean-Pierre
Published: October 2009

Histologic and electron microscopic studies of Solcoderm-treated normal skin and human lesions were performed to help elucidate the mode of action of this new agent. Its fixative properties were readily demonstrated and generally proved to be adequate for histological diagnosis from the post-treatment scab. The degree of preservation of fine intra-cellular structures was particularly remarkable, since similar treatment with equivalent strengths of nitric acid alone destroys these substructures. Dermal lipids and collagen were found to be natural barriers against the penetration of Solcoderm applied to the skin surface. Mild mechanical disruption and the disturbed cellular continuity of pathologic tissue allows the solution to penetrate treated lesions more freely and enhances the likelihood of their complete destruction when an appropriate quantity of solution is properly delivered by an experienced therapist.
Cumulative Experience with Solcoderm in the Treatment of Basal Cell Epithelioma
Authors: Schewach-Millet Miriam , Azizi Esther , Semah David
Published: October 2009

Over 300 patients with basal cell epithelioma have been treated with Solcoderm during the past 4 years. The treatment is simple and effective for small superficial lesions and particularly useful in patients with periocular or multiple lesions.
Solcoderm Treatment of Epidermal Growths Including Intradermal Nevi
Authors: Haim S. † , Cohen A.
Published: October 2009

Solcoderm was used in the management of various epidermal growths in 372 patients with 1,002 lesions, including condyloma acuminatum, verruca plana, basal cell epithelioma, intradermal nevus, seborrheic and solar keratosis. No antiseptic precautions or local anesthesia were used during the treatment. The results seem promising and suggest that Solcoderm is a simple, safe, and efficient method for the management of these tumors. Cosmetic results were excellent. It is especially recommended when the lesions are in difficult to manage locations for surgical or other known chemical or physical methods, when the patient is not fit for surgical procedures, and when local anesthesia is contraindicated.
Long-Term (5–8 Years) Follow-Up of Solcoderm-Treated Malignant Skin Tumors
Authors: Ravid M. , Sohar E. , Krispin M. , Mardi S. , Semah D.
Published: October 2009

Long-term follow-up shows a low recurrence rate for Solcoderm treated small superficial basal cell epithelioma, and a high recurrence rate for larger malignant skin lesions.
Capillary Microscopy of the Nail Fold in Patients with Psoriasis and Psoriatic Arthritis
Authors: Zaric Dusanka , Clemmensen Ole J. , Worm Anne-Marie , Stahl Dorrit
Published: October 2009

The Capillary characteristics of the nail fold area were examined and compared by capillary microscopy in 31 patients with psoriasis (PS) and 34 patients with psoriatic arthritis (PA). 70 healthy persons served as controls. Significantly shorter mean capillary loop lengths and characteristic morphological capillary changes were found both in patients with PS and in patients with PA as compared to the controls. The number of hemorrhages and sluggishness of blood flow was more pronounced in both groups of patients as compared to the control group, but only significantly so in patients with PA. The only significant difference between the PS and the PA groups was a higher subpapillary plexus visibility (SPV) index in the latter. It is concluded that most of the capillary changes demonstrable in patients with PA are clinical manifestations of PS. The difference in the SPV index, however, warrants a follow-up study to elucidate whether patients with PS and a high SPV index are likely to develop arthritis.
Larva migrans with Eosinophilic Papular Folliculitis
Authors: Czarnetzki Beate M. , Springorum Michael
Published: October 2009

A patient with typical larva migrans lesions associated with a highly pruritic papular folliculitis is presented. The time course of the evolution and the pathological picture – with local accumulation of lymphocytes, mast cells and eosinophils – mirror a typical thymus-dependent reaction to parasitic infestation. The papular and serpiginous lesions did not respond to the same type of therapy.
Verruciform Xanthoma of the Oral Mucosa
Authors: Sklavounou Alexandra , Laskaris George , Angelopoulos Angelos
Published: October 2009

An additional case of verruciform xanthoma in the oral cavity is presented. The clinical and light microscopic findings in this case are similar to those previously described. In addition, the clinical features of 47 cases that could be found in the literature are summarized and discussed.
Relapsing Polychondritis
Authors: Hedfors Eva , Hammar Hans , Theorell Henning
Published: October 2009

4 patients with relapsing polychondritis are described. In 3 of the cases a vasculitic syndrome was concomitantly present. The possible significance of this association is discussed.
Perforating Granuloma annulare and Vitamin D
Authors: Aliaga Adolfo , Serrano Gabriel , de la Cuadra Jesús , Fortea José M.
Published: October 2009

The case of a 10-year-old boy who developed lesions of perforating granuloma annulare on the dorsum of both hands which was related to oral administration of vitamin D is presented.
Treatment of Palmoplantar Pustulosis with Tigason®
Authors: Thune Per
Published: October 2009

In a double-blind, cross-over trial with Tigason® and placebo, the parameters of palmoplantar pustulosis underwent significant changes during the retinoid therapy. A hang-over effect was clearly indicated during the placebo period and several patients experienced long-lasting remissions.
Failure to Demonstrate Fibrotic Changes in the Skin of Mice Injected with Glycosaminoglycan Fractions from the Urine of Scleroderma Patients
Authors: Fox P.K. , White D.D. , Cavanagh M. , Davies M.G. , Wusterman F.
Published: October 2009

Glycosaminoglycan (GAG) fractions isolated from the urine of scleroderma patients were compared with GAGs from control subjects for their ability to induce fibrotic changes in the skin of mice after intraperitoneal injection. Contrary to previous reports, however, no fibrotic changes were detectable, either visibly or in terms of skin tissue thickness. The ability to obtain consistently authentic biologically active factors from this source is therefore questioned.
Intercellular Immune Complexes in a Case of Bullous Pemphigoid
Authors: Trost Thomas H. , Galosi Attila , Enderer Klaus
Published: October 2009

In vivo bound epidermal intercellular immune complexes arranged in a pemphigus-like pattern have been evidenced in a case of bullous pemphigoid by a new immunohistological and immunoelectron-microscopic technique for the detection of immunoglobulins. Immunoelectron microscopy with peroxidase-labeled protein A has been performed to demonstrate these immune complexes at an ultrastructural level and to compare them with ‘classical’ pemphigus antibodies revealed by the same technique. Morphological differences could not be demonstrated by this technique.
A Method for the Study of the Effect of Barrier Creams and Protective Gloves on the Percutaneous Absorption of Solvents
Authors: Boman Anders , Wahlberg Jan E. , Johansson Gun
Published: October 2009

Solvents were administered into closed skin depots on guinea pigs and the resulting blood concentrations were measured in samples repeatedly obtained via a catheter in the carotid artery. The exposure areas were protected with glove membranes or with barrier creams rubbed into the skin before administration of the solvents. Results from experiments with two solvents, various gloves and barrier creams with claimed protective effects are presented. It is concluded that this animal model seems suitable for screening purposes and capable of differentiating between various commercial products.
In vivo Porphyrin Fluorescence from Propionibacterium acnes. A Characterization of the Fluorescing Pigments
Authors: Melø T.B. , Johnsson M.
Published: October 2009

The natural fluorescence from Propionibacterium acnes has been investigated in vivo. The fluorescence spectrum can be decomposed into three distinct emission spectra due to the presence of metal-free coproporphyrin, protoporphyrin and uroporphyrin in the bacteria. The amounts of these substances can be estimated from the in vivo fluorescence measurements, which may serve as a nondestructive technique to study the porphyrin metabolism.
Prolidase Deficiency: An Inborn Error of Metabolism with Major Dermatological Manifestations
Authors: Der Kaloustian Vazken M. , Freij Bishara J. , Kurban Amal K.
Published: October 2009

Prolidase deficiency is a very rarely reported inborn error of metabolism. It has important and severe dermatological manifestations, especially ulcers of the lower extremities. It has been reported from seven different countries. It is suspected that the disease is more common than presently acknowledged. It is suggested that this disease should be included on the list of causes of skin ulcers in order to have a higher index of suspicion for diagnosis.
Irritancy of Low Concentrations of Soap and Synthetic Detergents as Measured by Skin Water Loss
Authors: Hassing J.H. , Nater J.P. , Bleumink E.
Published: October 2009

The irritancy of low concentrations of commercially available soaps and detergents (surfactants) in bar form was determined by means of measurements of water loss of the skin. The percentage of increase of vapor (water) loss after application of the soap solutions was taken as a measure of skin irritancy. The tests were performed in 19 human volunteers with 1% solutions of Sporex, Devela, Lux, Lactacyd and Aveenoderm. Devela and Lactacyd were found to provoke marked effects, Lux was less harmful whereas Sporex and Aveenoderm did not lead to a considerable increase of skin vapor loss. Longitudinal studies showed that the irritant properties of soap solutions are additive. The results suggest that the influences of the pH of a soap solution on the skin-damaging effort is less important than assumed thus far.
The Efficacy of a Topical Preparation Containing Erythromycin in the Treatment of Acne
Authors: Puschmann M. , Meyer-Rohn J.
Published: October 2009

In vitro experiments demonstrate good penetration of a topical erythromycin preparation into the culture medium and an inhibition of germs that are regularly found in acne. In vivo examinations were performed in unilateral trials. Prior to and after treatment with the local therapeutic agent or the placebo, the anaerobic bacteria were collected from the ducts of the sebaceous glands by means of the cyanoacrylate method and were identified and counted. The erythromycin-containing acne therapeutic agent caused a significant reduction of Propionibacterium acnes and micrococcaceae relative to the vehicle and the initial value. The results demonstrate release of the active substance, erythromycin, from the galenic base, penetration into the ducts of the sebaceous glands, and an antibacterial effect at the infrain-fundibulum on propioni bacteria and micrococcaceae.
Contact Dermatitis to Bufexamac
Authors: Reijfers J.
Published: October 2009

Description of 3 cases of contact dermatitis to bufexamac cream, which is largely used in dermatology as a nonsteroid anti-inflammatory agent. Moreover, since this substance shows a distinct fluorescent spectra, we must not forget that a photodynamic phenomenon may play a part in the skin sensitization.
Impetigo Herpetiformis with Lowered Serum Level of Vitamin D and Its Diminished Intestinal Absorption
Authors: Ott F. , Krakowski A. , Tur E. , Lipitz R. , Weisman Y. , Brenner S.
Published: October 2009

A patient who suffered from impetigo herpetiformis during three successive pregnancies is described. Serum calcium was 8.0–8.9 mg/dl, serum 25-hydroxyvitamin D (25-OHD) and 24,25-dihydroxyvitamin D were low, and 25-OHD3 intestinal absorption was decreased.
Eosinophilic Cellulitis: A New Case
Authors: Varotti C. , Tosti A. , Gobbi M. , Martinelli G. , Patrizi A.
Published: October 2009

A case of eosinophilic cellulitis (Wells’ syndrome) is reported. In addition to the normally occurring clinical and histological features of Wells’ syndrome, a hematological disorder suggesting a myeloproliferative disease is present. Relationships between these hematological features and eosinophilic cellulitis are discussed.
Photochimiothérapie orale du parapsoriasis en gouttes
Authors: Thivolet J. , Ortonne J.P. , Gianadda B. , Gianadda E.
Published: October 2009

8 patients with parapsoriasis guttata were treated by oral photochemotherapy. In 6 of them, complete clearing was obtained. Many suggestions concerning the mechanism of action of oral photochemotherapy in parapsoriasis guttata are discussed.
Multiple Agminated Juvenile Melanoma: a Case with a Sunburn History, and a Review
Authors: Krakowski A. , Tur E. , Brenner S.
Published: October 2009

Multiple agminated and two isolated juvenile melanomas in a 4½-year-old boy, which appeared on apparently normal skin after sunburn, are described. Cases in the literature are reviewed.
Inhibitory Effect of Plasma on Photohaemolysis in Erythropoietic Protoporphyria
Authors: Joenje H. , Woutersen R.A. , Baart de la Faille H.
Published: October 2009

The effect of plasma and serum on the photohaemolysis of red cells from erythropoietic protoporphyria patients was studied. Low concentrations (up to 50–100 ml/l) markedly inhibited the rate of photohaemolysis, this effect being partially reversed at higher plasma concentrations. Most of the lysis-inhibiting material co-eluted with serum albumin on gel filtration columns, although a considerable inhibiting effect was also associated with higher molecular weight material. A significant part of the albumin effect can be ascribed to its protoporphyrin-binding capacity. However, most of the effect seems due to an as yet unidentified property of this protein. Evidence is presented that the effect of albumin must be somehow specific to the human protein, as albumins from other sources were much less effective.
Epithelioma Cuniculatum, a Verrucous Carcinoma of the Foot
Authors: Melo Carlos R. , Melo Ivanir S. , Souza Lenita P.
Published: October 2009

Epithelioma cuniculatum, a rare form of squamous cell carcinoma affecting the sole of the foot, was observed in 2 male patients aged 62 and 69 years, respectively. In each case the lesion consisted of a fungating mass with sinuses draining foul-smelling fluid with keratin debris.
Metastatic Malignant Melanoma
Authors: Tillman Larry J.
Published: October 2009

The unusual ultrastructure of a metastatic malignant melanoma is discussed. Light microscopy revealed most tumor cells to be nonpigmented, multinucleated giant cells. Electron microscopy demonstrated bizarre, cytoplasmic filaments void of melanin deposition. The internal structure of these filaments exhibited distinct periodicity similar to that seen in normal melanosomes.
HLA and Psoriasis in the Chinese
Authors: Chan S.H. , Tan T. , Wee G.B. , Kamarudin Ali , Rajan V.S
Published: October 2009

The HLA locus A, B and C antigen frequency of 70 unrelated Chinese patients with psoriasis were compared to that of 330 normal subjects. The frequency of Al, Aw30 and B13 were significantly elevated among patients compared to normals, even after correction for the number of antigens typed for. The joint occurrence of Aw30, B13 was observed in 20/70 (37.1%) patients compared to 8/330 (2.4%) normals (χ2 = 60.7, RR = 16.1). Aw30 and B13 were found to be in significant linkage disequilibrium in patients as well as normals.
Evaluation of Various Antigenic Substrates for the Detection of Antinuclear Antibodies
Authors: Tosca A. , Hatzis J. , Haidas A. , Varelzidis A.
Published: October 2009

The present study deals with the evaluation of some substrates for the detection of nuclear antibodies by the indirect immunofluorescence method. We have examined white male mouse liver imprint, white female pregnant mouse liver imprint, compound substrate consisting of male mouse liver, kidney and gastric wall sections, skin sections from psoriatic patients, skin sections from squamous cell carcinomata, male rabbit spleen imprint, skin sections from healthy adult people, skin sections from basal cell epitheliomata, skin sections from patients with lichen planus, male mouse spleen imprint and male guinea pig spleen imprint. To evaluate the substrates, we have employed 4 selected sera from patients with collagen disease. It was observed that some types of antinuclear antibodies demonstrate greater affinity for certain substrates and the fluorescent nuclear pattern might change on serial dilutions. From all the substrates studied, the white male mouse liver imprint and the male rabbit spleen imprint were considered as the most efficient for routine purposes as they are both sensitive and easily obtainable.