bluuebunny/crossref_metadata_2025 huggingface dataset:
Review on Intelligent Governance of Physical Fitness of College Students under the Background of Big Data
Authors: Liu Qing , Li Zhenzhi , Liu Shangli
Published: July 2022

The advent of the era of big data has promoted the reform of sports governance, and intelligent governance is becoming a strategic choice and a new trend to promote the physical fitness development of college students. Based on the profound analysis of the current situation of college students’ physical fitness, this study examines the great value of big data for the intelligent governance of physical fitness, and further constructs the model to achieve intelligent governance of college students’ physical fitness. The study also provides specific strategies to promote this process. According to the study, although the current situation of college students’ physical fitness is still not optimistic, data‐driven intelligent governance of physical fitness provides a new solution to a personalized, refined, and diversified way of governance. By creating an intelligent governance concept with data thinking, building an intelligent governance platform supported by data, and by such measures as improving the data literacy of physical education teachers in colleges and universities and upgrading stadiums with intelligent techniques, the study seeks to break through the bottleneck of college students’ physical fitness governance and open up a new path to realize the effective governance of college students’ physical fitness.
Disturbed Pitch Perception during Antidepressant Therapy of a Combination of Lithium, Nortriptyline, and Oxazepam: A Rare Unexpected and Undesirable Side Effect for a Violinist
Authors: de Groot Siwert
Published: July 2022

Disturbed pitch perception is a rare but well-known side effect of the antiepileptic drug carbamazepine and its derivates. A patient is presented who used three antidepressants because of depression. After recovering, the medication was continued, but as a violinist, the patient was told that his intonation was too low with the consequence that he was not allowed to participate in the orchestra where he had been for years. After phasing out the medications, his pitch perception returned to normal. This observation is unique as no other examples of this side effect are found in the literature in relation to antidepressants.
Experiment and Simulation on the Anticollision Performance of a New Corrugated Steel Protection System for Bridge Piers
Authors: Chen Guicheng , Huang Haidong , Xiang Zhongfu
Published: July 2022

To ensure the safety of ships and bridges at the same time during collisions, a new type of bridge pier protection system is proposed, in which one is composed of corrugated steel plates, bolts, and corrugated steel pipes (CSP), and the other is composed of ordinary steel plates, bolts, and corrugated steel pipes (OSP). To study their anticollision performance, a pendulum impact test and numerical simulation were carried out. Comparing the test results with the simulation results, it was shown that the simulation results are basically consistent with the test results. Then, the influence curves of the impact velocity, specimen thickness, weight, and frequency are analysed to evaluate the anticollision performance of CSP/OSP and optimize their structure. When the impact energy is low, the peak values of the lateral impact force and lateral displacement of the column equipped with OSP are all smaller than those of the column equipped with CSP. When the impact energy is high, the peak values of the lateral impact force and lateral displacement of the column equipped with OSP are larger than those of the column equipped with CSP. However, under the same impact energy, the total energy peak value of the CSP specimen is larger than that of the OSP specimen. Results can provide a certain numerical analysis basis for the structural design and research of new types of corrugated steel protection system for bridge pier.
Contemporary Advertising Text Art Design and Effect Evaluation by IoT Deep Learning under the Smart City
Authors: Zhang Likun , Li Xiaoyan , Tang Yi , Song Fangbin , Xia Tian , Wang Wei
Published: July 2022

This work intends to solve the problem that the current artistic typeface generation methods rely too much on manual intervention, lack novelty, and the single font local feature and the global feature extraction method cannot fully describe the font features. Firstly, it proposes a handwritten word recognition model based on generalized search trees (GIST) and the pyramid histogram of oriented gradient (PHOG). The local features and global features of the font are fused. Secondly, a model of automatic artistic typeface generation based on generative adversarial networks (GAN) is constructed, which can use hand-drawn fonts to automatically generate artistic typefaces in the desired style through training as needed. Finally, the generation of the huaniao typeface is used as an example. By constructing the dataset, the effectiveness of the two models is verified. The experimental results show the following: (1) The proposed handwritten character recognition model based on GIST and PHOG has a higher recognition rate of different fonts than the single GIST and PHOG features by more than 5.8%. The total recognition time is reduced by more than 49.4%, and the performance is improved significantly. (2) Compared with other popular algorithms, the constructed GAN-based automatic artistic typeface generation model has the best quality of the generation of huaniao on both the pencil sketch and the calligraphy character image dataset. Models have broad application prospects in contemporary advertising text art design. This study aims to provide important technical support for the automation of contemporary advertising text art design and the improvement of overall efficiency.
Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway
Authors: Ding Jiameng , WenjuanYang  , Jiang Yuhui , Ji Jie , Zhang Jie , Wu Liwei , Feng Jiao , Zheng Yuanyuan , Li Yan , Cheng Ziqi , Yu Qiang , Wu Jianye , Li Jingjing , Chen Kan , Guo Chuanyong
Published: July 2022

Hepatic ischemia/reperfusion injury (HIRI) is a common complication of liver surgery requiring hepatic disconnection, such as hepatectomy and liver transplantation. The aim of this study was to investigate the effects of cordycepin on HIRI and to elucidate the underlying mechanisms. Balb/c mice were randomly divided into six groups: a normal control group, sham group, H-cordycepin group, HIRI group, L-cordycepin (25 mg/kg) + HIRI group, and H-cordycepin (50 mg/kg) + HIRI group. Mice were subjected to I/R, and cordycepin was intragastrically administered for seven consecutive days before surgery. Orbital blood and liver specimens were collected at 6 and 24 h after HIRI. Serum levels of ALT and AST were decreased in the cordycepin pretreatment groups. Notably, cordycepin attenuated the inflammatory response and the production of proapoptosis proteins, while increasing expression of antiapoptosis proteins and decreasing expression of autophagy-linked proteins. Furthermore, cordycepin inhibited activation of the MAPK/NF-κB signaling pathway. Collectively, these results indicate that cordycepin pretreatment ameliorated hepatocyte injury caused by HIRI. As compared with the HIRI group, cordycepin pretreatment mitigated the inflammatory response and inhibited apoptosis and autophagy via regulation of the MAPK/NF-κB signaling pathway.
The Efficacy and Safety of Mizoribine versus Mycophenolate Mofetil for the Treatment of Renal Transplantation: A Systematic Review and Meta-Analysis
Authors: Chen Jie , Liu Hua , Yin Wenjun , Xu Zhengguang , Chen Zekai , Yiu Wingkeung
Published: July 2022

Background. Mizoribine (MZR) is widely used in Asia due to its high safety and low cost, and comparative studies of its safety and efficacy with the first-line drug mycophenolate mofetil (MMF) have been carried out. This paper aimed to compare the efficacy and safety of MZR and MMF in immunosuppressive therapy of renal transplantation by meta-analysis. Methods. We searched randomized controlled trials (RCTs) comparing MZR versus MMF for renal transplantation in PubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, WanFang Database, China National Knowledge Infrastructure (CNKI), and Chinese Biomedical Database (CBM). Articles were assessed for their risk of bias using the Cochrane Collaboration. Forest plots and funnel plots were also performed on the included articles. Results. A total of twelve studies with 1103 patients were selected in the analysis. No significant difference were observed between the MZR group and the MMF group for the rate of acute rejection (RR = 1.50, 95% CI 1.11 to 2.01, P = 0.008), patient survival (RR = 1.01, 95% CI 0.99 to 1.03, P = 0.56), graft survival (RR = 1.02, 95% CI 1.00 to 1.04, P = 0.12), leucopenia (RR = 0.69, 95% CI 0.44 to 1.10, P = 0.12), and liver damage (RR = 0.72, 95% CI 0.46 to 1.13, P = 0.15). The MZR group was associated with a lower risk of gastrointestinal disorder (RR = 0.28, 95% CI 0.13 to 0.62, P = 0.002) and cytomegalovirus infection (RR = 0.59, 95% CI 0.42 to 0.84, P = 0.003) but had a higher risk of hyperuricemia (RR 1.79, 95% CI 1.17 to 2.75, P = 0.007). No significant publication bias was observed among included studies. Discussion. MZR is similar to MMF in efficacy, and in terms of safety, MZR has a lower risk of gastrointestinal disorder and cytomegalovirus infection but a higher risk of hyperuricemia.
Serum TGF-β1 and VEGF Levels Reflect the Liver Hardness and Function in Children with Biliary Atresia
Authors: Chang Dongzhe , Geng Xianjie , Zhou Liang , Hou Guangjun
Published: July 2022

Objective. This study further explored the wind direction correlation analysis between serum levels of TGF-β1 and VEGF and liver function assessment in children with biliary atresia. Methods. A total of 62 children with biliary atresia (BA) who received surgical treatment in our hospital from October 2020 to October 2021 were selected as the research objects (BA group), and 50 normal healthy children who received routine physical examination in our hospital during the same period were selected as blank control group. Outcome measures included postoperative total bilirubin levels and conjugality of enrolled patients. Bilirubin level, unbound bilirubin level, serum transforming growth factor-beta-1 (TGF-β1), vascular endothelial growth factor (VEGF), liver function indicators albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and other observation indicators were included. All data in this study were collected and analyzed by SPSS 23.0 software, and

t

-test was performed. Results. The serum levels of TGF-β1, VEGF, ALT, AST, GGT, and liver hardness were significantly higher in children with jaundice than those without jaundice, and the serum ALB level was significantly lower than that in children without jaundice (

P
<
0.05

). The levels of TGF-β1 and VEGF in BA group were positively correlated with the levels of ALT, AST, GGT, and liver hardness (

P
<
0.05

) but negatively correlated with the level of ALB (

P
<
0.05

). Conclusion. The levels of serum TGF-β1 and VEGF in children with biliary atresia have a certain risk correlation with liver function damage, which will become a research focus on the mechanism of liver fibrosis in the diagnosis and treatment of biliary atresia in children.
[Retracted] Cyclic GAN Model to Classify Breast Cancer Data for Pathological Healthcare Task
Authors: Chopra Pooja , Junath N. , Singh Sitesh Kumar , Khan Shakir , Sugumar R. , Bhowmick Mithun
Published: July 2022

An algorithm framework based on CycleGAN and an upgraded dual‐path network (DPN) is suggested to address the difficulties of uneven staining in pathological pictures and difficulty of discriminating benign from malignant cells. CycleGAN is used for color normalization in pathological pictures to tackle the problem of uneven staining. However, the resultant detection model is ineffective. By overlapping the images, the DPN uses the addition of small convolution, deconvolution, and attention mechanisms to enhance the model’s ability to classify the texture features of pathological images on the BreaKHis dataset. The parameters that are taken into consideration for measuring the accuracy of the proposed model are false‐positive rate, false‐negative rate, recall, precision, and F1 score. Several experiments are carried out over the selected parameters, such as making comparisons between benign and malignant classification accuracy under different normalization methods, comparison of accuracy of image level and patient level using different CNN models, correlating the correctness of DPN68‐A network with different deep learning models and other classification algorithms at all magnifications. The results thus obtained have proved that the proposed model DPN68‐A network can effectively classify the benign and malignant breast cancer pathological images at various magnifications. The proposed model also is able to better assist the pathologists in diagnosing the patients by synthesizing the images of different magnifications in the clinical stage.
Therapeutic Potential of Different Natural Products for the Treatment of Alzheimer’s Disease
Authors: Chakraborty Biswajit , Mukerjee Nobendu , Maitra Swastika , Zehravi Mehrukh , Mukherjee Dattatreya , Ghosh Arabinda , Massoud Ehab El Sayed , Rahman Md. Habibur
Published: July 2022

A high incidence of dementia (60–80%) and a high rate of memory loss are two of the most common symptoms of Alzheimer’s disease (AD), which affects the elderly. Researchers have recommended that traditional Chinese medicine (TCM) and Indian medicines can be used to prevent and cure AD. Several studies have linked neuroinflammation linked to amyloid-β (Aβ) deposition in the brain to the pathophysiology of neurodegenerative disorders. As a result, more research is needed to determine the role of inflammation in neurodegeneration. Increased microglial activation, cytokine production, reactive oxygen species (ROS), and nuclear factor kappa B (NF-κB) all play a role in the inflammatory process of AD. This review focuses on the role of neuroinflammation in neuroprotection and the molecular processes used by diverse natural substances, phytochemicals, and herbal formulations in distinct signaling pathways. Currently, researchers are focusing on pharmacologically active natural compounds with the anti-neuroinflammatory potential, making them a possible contender for treating AD. Furthermore, the researchers investigated the limits of past studies on TCM, Indian Ayurveda, and AD. Numerous studies have been carried out to examine the effects of medicinal whole-plant extracts on AD. Clinical investigations have shown that lignans, flavonoids, tannins, polyphenols, triterpenoids, sterols, and alkaloids have anti-inflammatory, antiamyloidogenic, anticholinesterase, and antioxidant properties. This review summarizes information about numerous medicinal plants and isolated compounds used in the treatment of AD and a list of further references.
Blasting for Fracturing and Improving the Permeability of Deep, Soft, Outburst Prone Coal Seams Using Blasthole and Relief Hole Drilled into the Underlying Stratum: Optimal Hole Distance
Authors: Zhang Jianyu , Zhao Xingguo , Fu Shigui , Qiao Guodong , Zhang Xin , Yang Shuai
Published: July 2022

To address the problems with deep-hole presplit blasting intended to fracture and improve the permeability of deeply buried, soft, high-gas-content coal seams, a method using a blasthole and a relief hole drilled into the underlying rock stratum was proposed. By establishing a theoretical model for this purpose, the stress wave propagation characteristics during the blasting process were analyzed, and the working mechanisms of the relief hole and the stress transmission characteristics were investigated. The blasting of the C13-1 coal seam in the Huainan mining area under different in situ stress conditions using different blasthole–relief hole distances was simulated using an implicit–explicit coupled method and the ANSYS/LS-DYNA software. The results showed that the blasting-induced stress wave was reflected from the coal–rock interface and transformed into a tensile wave owing to the different wave impedances of coal and rock, thereby fracturing the rock and coal masses better and achieving the intended permeability improvement effect. A free surface effect was produced near the relief hole during the blasting process, which directed the stress wave to propagate in the direction of the relief hole, thereby promoting fracturing in that direction. The in situ stress inhibited the blasting-induced fracturing in the coal mass. Thus, for blasting intended to improve the permeability of deeply buried coal masses, the blasthole–relief hole distance should be reduced to achieve better fracturing. Our results have a certain reference value for directional blasting intended to fracture and improve the permeability of deeply buried, soft, high-gas-content coal seams.
Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks
Authors: Xu Tong
Published: July 2022

The process of tumor growth and deterioration is accompanied by increased oxygen free radicals, high glutathione concentration, hypoxia, and poor drug targeting during treatment, limiting the treatment of tumors. Metal-organic framework (MOF) preparations are continuously being developed and applied in tumor therapy. In this paper, the design and application of reactive oxygen species (ROS) and redox drug-loaded MOF preparations are reviewed. Moreover, the research challenges and application prospects of MOFs in tumor therapy are also discussed.
The Effects of Phellodendron Decoction on Wound Healing of Anal Fistula after Anal Fistulotomy
Authors: Deng Heng , Zhang Jun , Yuan Xiancang
Published: July 2022

Objective. To analyze the therapeutic effect of Compound Phellodendron decoction on wounds after anal fistulotomy. Methods. 100 patients with anal fistula who underwent anal fistulotomy from April 2019 to April 2021 were included in the study group and control group according to the random number table method. 50 patients in the study group were treated with Compound Phellodendron decoction by fumigation and sitting bath, while warm water replaced Compound Phellodendron decoction in the control group. Perianal pain, wound edema, and exudation were scored on postoperative days 3 and 7, and wound healing time was recorded. Interleukin-2(IL-2), IL-5, IL-6, and IL-12 were measured via a double-antibody sandwich enzyme-linked immunosorbent assay. Hematoxylin-eosin (HE) staining and immunofluorescence were used to quantitatively analyze the capillary number and CD4+ and CD8+ lymphocytes in granulation tissue on postoperative days 7. Results. The scores of pain, edema, and exudation in 2 groups on postoperative day 7 were lower than those on the 3rd postoperative day. Compared with the control group, the pain, edema, and exudation scores in the study group were decreased, and the wound healing time was shortened; the expressions of IL-2 and IL-12 in the study group were significantly increased, while the expressions of IL-5 and IL-6 were decreased; the number of capillaries and CD4+ lymphocytes in the study group was increased, while the number of CD8+ lymphocytes was decreased. Conclusion. Compound Phellodendron decoction had efficacy in promoting wound healing, reducing complications, and changing lymphocyte aggregation and alleviating local inflammatory response.
Highly Efficient MIMO-OFDM with Index Modulation
Authors: Hu Zeng , Wan Dehuan , Chen Yankun , Yan Jinpei , Liu Yun , Guo Pengfei , Chen Liming , Zhou Wen
Published: July 2022

Index modulation (IM) is a novel digital modulation technique, which inactivates some subcarriers in orthogonal frequency division multiplexing (OFDM) to exploit the indices of the subcarriers to transmit bits implicitly, and has potential to further improve the energy efficiency and error performance. For the multiple-input multiple-output- (MIMO-) aided IoT devices, a highly efficient and low-complexity IM-aided scheme is needed to reduce the computational complexity at the receiver sides. In this paper, we propose a novel highly efficient MIMO-OFDM with IM scheme by performing IM on each transmit antenna subgroup, which contains two transmit antennas, to achieve two transmit diversity order and significant reduction in computational complexity at the cost of a minor spectral efficiency. To reduce the demodulation complexity, a low-complexity sequential Monte Carlo (SMC) theory-based detector is proposed, which exploits the null space submatrix of the preprocessed channel response matrix by using QR decomposition, to calculate the most likely transmitted IM patterns before the detection of the modulated symbols. Computer simulation results and complexity analysis show that the proposed IM-aided scheme achieves better error performance with extremely low computational complexity under the same constellation and the proposed SMC detector has potential to achieve near optimal bit error rate performance with considerably low demodulation complexity.
Systems Theory and Evidence‐Based Decision‐Making as Keys for Arbitrating between Optimal Production and Efficient Maintenance: A Case Study
Authors: Hallioui Anouar , Herrou Brahim , Santos Ricardo , Katina Polinpapilinho , Khadiri Hassan , Egbue Ona
Published: July 2022

Organizations in the 21st century operate in evolving and highly competitive environments—such environments are catalysts for deviation in organization‐planned operations, including production and maintenance. The differences between maintenance and production, in general, are well known, given the several studies found in the literature regarding industrial engineering. However, the differences between maintenance and production are becoming less significant as a result of increased understanding of the systemic approach to organizations where the whole matters more than the sum of the parts. The aim of this study was to maximize the productivity of a manufacturing factory by applying mathematical programming methods while simultaneously considering the requirements of efficient maintenance. A case study is used to show how systems theory can be used as the basis for evidence‐based decision‐making in a factory manufacturing line in Morocco. Despite the potential for conflict between optimal production objectives and efficient maintenance in high‐performance factories, the four‐month case application suggests that systems theory is a key for arbitration. Research implications are presented along with future research directions.
LncRNA NEAT1 Targets miR-342-3p/CUL4B to Inhibit the Proliferation of Cutaneous Squamous Cell Carcinoma Cells
Authors: Gong Zhenhua , Zhang Yi , Jiang Yasu , Chen Peng , Ji Jianfeng
Published: July 2022

Objective. This study investigated whether lncRNA NEAT1 could inhibit the proliferation of cutaneous squamous cell carcinoma (CSCC) cells by targeting miR-342-3p/CUL4B, thereby affecting the occurrence and development of CSCC. Methods. Fluorescence quantitative PCR was used to detect the expression of lncRNA NEAT1 and miR-42-3p in skin squamous cell carcinoma and adjacent tissues. Bioinformatics software and luciferase reporter gene assay were used to analyze the association of lncRNA NEAT1 and miR-342-3p. The effect of overexpression or knockdown of miR-342-3p on the proliferation of CSCC cells was examined by MTT and colony formation assays. Western blotting was used to detect the proteins of the miR-342-3p/CUL4B signaling axis. Results. The lncRNA NEAT1 is abnormally overexpressed in CSCC tissues and cell lines. The expression of lncRNA NEAT1 and miR-342-3p in CSCC was negatively correlated. Bioinformatics prediction analysis revealed that lncRNA NEAT1 regulates the expression of miR-342-3p. The results of MTT and plate colony formation experiments showed that the transfection of miR-342-3p mimics significantly inhibited the proliferation and plate colony formation of CSCC cells, while the transfection of miR-342-3p inhibitor significantly promoted the proliferation and plate colony-forming ability of CSCC cells. Western blot results showed that lncRNA NEAT1 affected CSCC cell proliferation through miR-342-3p/CUL4B/PI3K-Akt signaling pathway. Conclusion. The expression of lncRNA NEAT1 and miR-342-3p in CSCC tissues was negatively correlated. This study is the first to demonstrate that the lncRNA NEAT1, as a ceRNA, affects the proliferation of skin squamous cell carcinoma cells through the miR-342-3p/CUL4B/PI3K-Akt signaling pathway. Therefore, lncRNA NEAT1 could be a biological marker or target for CSCC diagnosis or treatment.
The Choice of Anticoagulant Influences the Characteristics of Bone Marrow Aspirate Concentrate and Mesenchymal Stem Cell Bioactivity In Vitro
Authors: Dregalla Ryan C. , Herrera Jessica Ann , Koldewyn Lucanus Steven , Donner Edward Jeffery
Published: July 2022

Bone marrow aspirate concentrate (BMC) is commonly used as a therapeutic agent to resolve orthopedic injuries, using its unique cellularity to reduce inflammation and prime the region for repair. The aspiration of the bone marrow is performed using either sodium citrate (SC) or heparin sodium (HS) as an anticoagulant and processed via centrifugation to concentrate the cellular constituents. To date, the consideration of the impact of the two commonly used anticoagulants on the mesenchymal stem/stromal cell (MSC) population has been overlooked. The current study assesses the differences in the BMCs produced using 15% SC and HS at 1,000 U/mL or 100 U/mL finalv./v.as an anticoagulant using in vitro metrics including total nucleated cell counts (TNC) and viability, the ability for mesenchymal stromal/stem cells (MSCs) to establish colony-forming units with fibroblast morphology (CFU-f), and cytokine expression profile of the MSC cultures. Our findings demonstrate that HS-derived BMC cultures result in higher CFU-f formation and CFU-f frequency at both concentrations assessed compared to SC-derived BMC cultures. In addition, there were significant differences in 27% (7 of 26) of the cytokines quantified in HS-derived BMC cultures compared to SC-derived BMC cultures with implications for MSC plasticity and self-renewal.
Application of Data Image Encryption Technology in Computer Network Information Security
Authors: Li Li
Published: July 2022

In order to solve the practical problem that the security of computer network information cannot be guaranteed, which seriously affects the network performance, the author proposes a public key data encryption system based on PKI. The system proposed by the author is based on the public key cryptographic algorithm RSA, including implementation of data encryption and digital signature and key distribution, an improved RSA algorithm is proposed for the slow speed of RSA. The result obtained is as follows: after reasonable selection of parameters and the use of optimized algorithms (also known as combined algorithms), the RSA algorithm is about 1.0% to 2% more efficient than the traditional algorithm, to a certain extent, the operation efficiency of the RSA algorithm is improved, and the purpose of improving the RSA algorithm is achieved. It is proved that the public key data encryption system is of great significance for modern computer network information encryption and maintaining a green and secure network environment.
Intelligent Three-Dimensional Reconstruction Algorithm-Based Ultrasound-Guided Nerve Block in Intraoperative Anesthesia and Postoperative Analgesia of Orthopedic Surgery
Authors: Liu Cuijie , Li Lin , Zhou Xuan , Wang Xiuyan
Published: July 2022

This research was aimed at analyzing the role of ultrasound-guided nerve block based on intelligent three-dimensional (3D) reconstruction algorithm in intraoperative anesthesia and postoperative analgesia of orthopedic surgery. 68 elderly patients were undergoing orthopedic surgery on the lower extremities, and they were randomly rolled into two groups with 34 patients in each group. The patients in control group received sciatic nerve block anesthesia (SNBA), and the patients in the experimental group received ultrasound-guided SNBA (UG-SNBA) under 3D reconstruction algorithm to analyze and compare the anesthesia effect and the postoperative analgesia effect. The results showed that compared with other algorithms, the evaluation index of ultrasound images processed by the 3D reconstruction algorithm was better. In terms of anesthesia effect, there was no significant difference in systolic blood pressure, diastolic blood pressure, and heart rate between the two groups before surgery (

P
>
0.05

). Intraoperative and postoperative indicators of the experimental group were significantly better than those of the control group; the drug dosage (61 mg) was less than that of the control group (78 mg). In addition, the onset time of anesthesia, the time of pain blockade, and the postoperative awake time (5 minutes, 8 minutes, and 8 minutes, respectively) were shorter than those in the control group (13 minutes, 15 minutes, and 15 minutes, respectively). The visual analogue scale (VAS) scores of the experimental group were better than those of the control group on the day after surgery, one day after surgery, two days after surgery, and three days after surgery, with significant differences (

P
<
0.05

). In summary, 3D reconstruction algorithm-based ultrasound image effect was clearer, the effect of UG-SNBA was more stable, and the postoperative analgesic effect was better. This work provided a higher reference for the selection of safe and effective anesthesia options in orthopedic surgery.
The Development of Privacy Protection Standards for Smart Home
Authors: Liu Donghang , Wu Chensi , Yang Lulin , Zhao Xiaoying , Sun Qifeng
Published: July 2022

With the rapid development of network technology, society has entered the Internet of Things (IoT) era. Enriching IoT devices enable smart home privacy information to be easily obtained through data mining. Smart home privacy protection (SHPP) has a far­reaching impact on the development of all aspects of society. Industrial and academic circles pay great attention to the privacy protection of the smart home, and the ability to protect the privacy needs to be improved. SHPP standards are one way to evaluate privacy protection capabilities at this stage. Based on our research on privacy protection standards, this paper summarizes the development of privacy protection standards for the first time. It divides them into three phases: creation, exploration, and expansion. According to the characteristics of the privacy data rotation, the SHPP standard system is proposed, including basic commonality, critical technology, auxiliary management, test and certification, and device application. Finally, we focus on the opportunity and challenges of smart home privacy security standards brought by the current big data and prospect the trend of privacy protection technologies and standard study. They provide a connection for subsequent standard investigations.
Inmunoterapia con alérgenos para enfermedades alérgicas de las vías respiratorias: Aprovechar las lecciones del pasado para diseñar un futuro mejor
Authors: Hesse Laura , Elberink J.N.G. Oude , van Oosterhout Antoon J.M. , Nawijn Martijn C.
Published: July 2022

Las enfermedades respiratorias de origen alérgico, como la dermatitis alérgica, la alergia alimentaria, la rinoconjuntivitis y el asma alérgicas, son padecimientos inflamatorios crónicos con prevalencia creciente. Los síntomas incluyen prurito ocular y lagrimeo, escozor en la boca o la piel, hinchazón en la cara o la garganta, estornudos, congestión o vómitos, sibilancias, dificultad respiratoria y tos. En el asma alérgica puede presentarse opresión en el pecho, tos, sibilancias y limitación reversible del flujo de aire. Estos síntomas pueden desencadenarse por la inhalación de alérgenos, sean de origen alimentario o transportados por el aire, como los procedentes del polen de los árboles o de la hierba y los ácaros del polvo doméstico. La intervención farmacológica en las enfermedades alérgicas incluye el uso de antihistamínicos, fármacos inmunosupresores y, en el caso del asma, beta-agonistas (de acción prolongada) para relajar las vías respiratorias constreñidas. Estas opciones de tratamiento sólo suprimen los síntomas, no curan la enfermedad. La inmunoterapia con alérgenos (ITA), en cambio, es capaz de inducir tolerancia a largo plazo, con un alivio de los síntomas que persiste décadas después de la interrupción del tratamiento a pesar de la reexposición recurrente al alérgeno. Sin embargo, la ITA no es eficaz para todos los trastornos alérgicos, y se requieren varios años de tratamiento para obtener una protección a largo plazo. Además, algunas formas de ITA presentan problemas de seguridad, con riesgo de reacciones alérgicas de leves a graves. Para mejorar la seguridad y la eficacia de la ITA, se han estudiado ampliamente los mecanismos subyacentes en la clínica y en modelos experimentales de inflamación alérgica de las vías respiratorias. Aunque se cuenta con más de un siglo de experiencia clínica y un amplio conjunto de estudios experimentales y traslacionales sobre los mecanismos inmunológicos y celulares que sustentan su potencial terapéutico, la ITA aún no se emplea en la atención clínica habitual del asma alérgica. Esta revisión ofrece una visión general de los avances sustanciales que amplían nuestro conocimiento de la patogénesis de las enfermedades alérgicas de las vías respiratorias, el mecanismo de acción de la ITA, sus vías y regímenes de tratamiento, la estandarización de los extractos y el uso de adyuvantes. Además, se resumen las principales conclusiones derivadas de los modelos experimentales de la ITA sobre la seguridad y la eficacia del tratamiento, y se esbozan las direcciones futuras para nuevos avances. La ITA requiere urgentemente nuevas mejoras para aumentar su eficacia y abreviar el tratamiento, sin dejar de ser segura y asequible.
Ferritin and Neurotoxicity: A Contributor to Deleterious Outcomes for Subarachnoid Hemorrhage
Authors: Panther Eric James , Zelmanovich Rebecca , Hernandez Jairo , Dioso Emma Rose , Foster Devon , Lucke-Wold Brandon
Published: July 2022

Background: Ferritin is a protein that is critical for storing iron. Ferritin has recently been shown to play a role in iron homeostasis, immunomodulation, inflammation, and antioxidation. Previously, it was believed that ferritin was exclusively an intracellular peptide. However, there is significant evidence that ferritin is also in the serum, cerebral spinal fluid, and synovial fluid. Summary: Within the brain, ferritin can bind to oligodendrocytes adjacent to the blood-brain barrier to allow a docking point for ferritin to be engulfed by microglia in the brain parenchyma. When iron supplies in the brain are low, the lysosomal-autophagy pathway is activated to degrade ferritin and mobilize iron. Iron is critical in the brain for the formation of myelin and used during cellular respiration. If this sequestration and degradation of iron are impaired, the oxidative effects of iron may leave the brain vulnerable to neurotoxic effects. Subarachnoid hemorrhage (SAH) causes hemolysis of erythrocytes leading to the release of iron. Subsequently, a rise in ferritin is observed which promotes the neurologic insult following SAH. The degree to which ferritin is elevated post-SAH may correlate with the downstream neurotoxicity. Key Messages: The literature seems to point to a critical balance in ferritin levels. Ferritin is protective against further oxidative effects of iron, but ferritin also contributes to neurotoxic outcomes. In this review, we will discuss the role of ferritin in the brain. Specifically, we will address cerebral ferritin iron uptake and ferritin clearance. This homeostatic process influences the development and progression of SAH.
Circ_0068087 Promotes High Glucose-Induced Human Renal Tubular Cell Injury through Regulating miR-106a-5p/ROCK2 Pathway
Authors: Feng Fen , Yang Jie , Wang Gang , Huang Ping , Li Yongjie , Zhou Bin
Published: July 2022

Background: Many studies have confirmed that circular RNA (circRNA) is an important target for regulating human disease progression. This study aimed to explore the role of circ_0068087 in diabetic nephropathy (DN) progression. Methods: High glucose (HG)-induced renal tubular cells (HK2) were used to mimic DN cell models in vitro. The expression levels of circ_0068087, microRNA (miR)-106a-5p, and Rho-associated coiled-coil-containing kinase 2 (ROCK2) were detected by quantitative real-time PCR. Cell proliferation and apoptosis were examined by cell counting kit-8 assay, 5-ethynyl-2′-deoxyuridine assay, colony formation assay, and flow cytometry. The protein levels were examined by Western blot analysis. Cell oxidative stress was assessed by measuring MDA level and SOD activity, and cell inflammation was evaluated by detecting the concentrations of inflammatory factors. RNA interaction was verified by dual-luciferase reporter assay and RNA pull-down assay. Results: The present study showed that circ_0068087 was highly expressed in the serum of DN patients and HG-induced HK2 cells. Interference of circ_0068087 alleviated HG-induced apoptosis, oxidative stress, inflammation, and fibrosis in HK2 cells, while accelerated cell proliferation. miR-106a-5p could be sponged by circ_0068087, and its inhibitor eliminated the regulation of circ_0068087 knockdown on HG-induced HK2 cell injury. ROCK2 was a target of miR-106a-5p, and its expression was suppressed by circ_0068087 knockdown. miR-106a-5p overexpression suppressed HG-induced HK2 cell injury, and this effect was reversed by ROCK2 upregulation. Conclusion: Our data indicated that circ_0068087 downregulation mitigated HG-induced HK2 cell injury through the miR-106a-5p/ROCK2 axis, providing a potential circRNA-targeted therapy for DN.
Mesenchymal Stromal Cell Secretome for Therapeutic Application in Skin Wound Healing: A Systematic Review of Preclinical Studies
Authors: Marques da Silva Maiara , Olsson Débora Cristina , Teixeira Bianca Luise , Jeremias Talita da Silva , Trentin Andrea Gonçalves
Published: July 2022

Non-healing skin wounds remain a challenge in the healthcare system. In this sense, it is suggested that the secretome of mesenchymal stromal cells (MSCs) can be effective as a therapeutic strategy for regenerative medicine. Therefore, this systematic review aimed to determine the effects of treatment with a secretome derived from MSCs on the healing of skin wounds in a preclinical model of rodents (mice and rats). Studies were systematically retrieved from 6 databases and gray literature that provided 1,172 records, of which 25 met the inclusion criteria for qualitative analysis. Results revealed substantial heterogeneity among studies concerning experimental designs and methodologies, resulting in a high risk of bias. Together, the selected studies reported that treatment improved wound healing by (1) accelerating wound closure and improving skin repair quality; (2) reducing inflammation by decreasing the number of cells and inflammatory cytokines, accompanied by polarization of the M2 macrophage; (3) complete re-epithelialization and epidermal reorganization; (4) neovascularization promoted by proliferation of endothelial cells (CD34+) and increased levels of pro-angiogenic mediators; (5) better scar quality promoted by increased expression of collagen types I and III, as well as improved deposition and remodeling of collagen fibers. In conclusion, despite the need for alignment of methodological protocols and transparent reports in future studies, results show that the secretome of MSCs from different tissue sources corresponds to a promising tool of regenerative medicine for the treatment of skin wounds.
The combination of user experience evaluation method in asessing the application of suicide risk idea identification
Authors: Wahyuningrum Tenia , Fadila Fitriana Gita , Wahyuningsih Dyah
Published: July 2022

The global pandemic COVID-19 has led to extreme loss of human life worldwide. The pandemic has made a profound impact on the psyche of some people, and it has led to suicide. The need for confident handling of specific risk factors for suicide is needed. Therefore, to support Indonesian governments to control the increment of suicidal ideas for adolescents using a combination of unmoderated remote usability testing (URUT) and usability metric for user experience (UMUX)-Lite. Then we adopted the school-based mental health program to make a prototype mobile application using the risk factor for suicidal ideation (RFSI) instrument to identify suicidal ideas in adolescents. Participants’ characteristics included late adolescents aged 19-22 years, male and female. The results show that the time-based efficiency on the registered task obtained from the calculation is 0.025 goals/sec. In one second, participants could complete a 0.025 of the job; although all participants could complete all tasks well and quickly, they provided good satisfaction scores. Some design improvements are needed on the prototype by considering user input.
Staff scheduling for a courier distribution centre using evolutionary algorithm
Authors: Si Ying Pua , Mohd Yusoh Zeratul Izzah
Published: July 2022

Staff scheduling is a combinatorics optimization problem and companies face this complex task on daily basis in constructing a schedule fitting all conditions. In a courier distribution center, staffs are assigned to work in processes of a continuous workflow. Staffs have varying work ability for each process. Instead of generating staff schedule instinctively, it is an advantage to optimize staff’s schedule by measuring the performance of each staff. An optimized schedule improves the operation’s efficiency and fully utilize staffs’ work ability, hence, minimizing the cost. This paper proposed evolutionary algorithm, namely genetic algorithm as the solution to courier center staff scheduling. Based on the result, the produced schedule can reduce up to 30% of the staff in schedule while not affecting operation workflow. The cut down on number of working staffs could amount to a substantial reduction of operation cost every month. The generated schedule is significantly customized and take less time to complete an operation. Although the proposed solution is specific to the use case of a courier distribution center, it is however, potentially a generalize model for the logistics industry, introducing a more effective staff scheduling system to cope with the industry’s ever-rising demands.
Hindi to English transliteration using multilayer gated recurrent units
Authors: Zeeshan Ansari Mohd , Ahmad Tanvir , Sufyan Beg Mirza Mohd , Ahmad Faiyaz
Published: July 2022

Transliteration is the task of translating text from source script to target script provided that the language of the text remains the same. In this work, we perform transliteration on less explored Devanagari to Roman Hindi transliteration and its back transliteration. The neural transliteration model in this work is based on a sequence-to-sequence neural network that is composed of two major components, an encoder that transforms source language words into a meaningful representation and the decoder that is responsible for decoding the target language words. We utilize gated recurrent units (GRU) to design the multilayer encoder and decoder network. Among the several models, the multilayer model shows the best performance in terms of coupon equivalent rate (CER) and word error rate (WER). The method generates quite satisfactory predictions in Hindi-English bilingual machine transliteration with WER of 64.8% and CER of 20.1% which is a significant improvement over existing methods.
Comparative study of net energy metering and feed-in tariff for the 496kWp UiTM segamat solar photovoltaic system
Authors: Zambri Muhamad Firdaus , Othman Muhammad Murtadha , Hasan Kamrul , Hidayat Muhamad Nabil , Ismail Abdul Kadir , Musirin Ismail
Published: July 2022

The Energy and natural resources ministry (KeTSA) of Malaysia has introduced the net energy metering (NEM) 3.0, which provides an opportunity for consumers to install solar photovoltaic (PV) systems to reduce electricity bills. The NEM 3.0 introduces three new initiatives that offer 500 MW quota from 2021 till 2023. NEM has been implemented since 2016, replacing the feed-in tariff (FiT) strategy by promoting the users to utilize the generated energy in the first place before selling any surplus to the utility. As in the FiT strategy, users can only sell the generated energy at a fixed rate without utilizing it. This paper presents the comparative study between NEM and FiT for 496 kWp solar photovoltaic system in UiTM Segamat, Johor in the perspective of economy and energy practice based on the simulation result of MATLAB/Simulink software.
Utilizing the right phosphor in near-ultraviolet and blue light-emitting diode devices to generate white illumination
Authors: Nguyen Thi Dieu An , Quoc Anh Nguyen Doan , Xuan Le Phan
Published: July 2022

In the scenario of solid-state lighting (SSL) gradually replacing old standard techniques; the pc-LEDs (or diodes based on conversion phosphor) becomes a common method for creating white illumination, based on SSL. As of now, both of the UV-LEDs and the blue LEDs have been still being considered for the task of creating white illumination through phosphor excitation as it hasn’t been known which LED type is truly superior. It is common that when it comes to phosphor, people will overlook the performance in LED devices with a wavelength range of 365 nm to 470 nm. Our research demonstrates the information concerning extrinsic quantum efficacy in the InxGa1-xN LED devices with the mentioned range as well as combines the information and the effectiveness of phosphor for the task of examining the performance of near-UV and blue LEDs and creating white illumination. In addition, the research demonstrates recreations for the task of assessing the white illumination mixtures under the correlated color temperature of 3000 K and 4000 K in the two LED structures.
High-efficiency green and red phosphors enable a broader hue-gamut light-emitting diode backlight for brighter displays
Authors: Nguyen Thi Dieu An , Xuan Le Phan
Published: July 2022

In this article, we suggest combining a blue InGaN chip with strait-band green (β-sialon:Eu2+), red (K2SiF6:Mn4+) phosphors to create WLED devices with a wide hue range and high effectiveness that may be utilized in LCD backlighting. The highest radiation wavelength of a gas-pressure sinted
β-sialon:Eu2+ is 535 nm, the full width at half maximum (FWHM) is 54 nm, and the outside quantum performance is 54.0% lower than the 450 nm stimulation. We created K2SiF6:Mn4+ in two steps. The phosphor possesses a sharp line radiation spectrum accompanied by the most intense maximum point under 631 nm, an FWHM reaching roughly 3 nm, as well as an exterior quantum effectiveness of 54.5%. When computed at 120 mA, the manufactured three-range wLEDs had an illuminating performance of 91–96 lm/W and a large color temperature of 11,184–13,769 K (i.e., 7,828–8,611 K in LCD screens). The hue range represented by the CIE 1931 and CIE 1976 hue gaps is 85.5-85.9% and 94.3-96.2% of the NTSC requirement, respectively.  The optic characteristics outperform those of phosphor-transformed wLED backlights utilizing broad-range green or red phosphors, indicating the two strait-range phosphors studied are the best luminous substances for producing brighter and livelier screens.