bluuebunny/crossref_metadata_2025 huggingface dataset:
Untargeted Phytochemical Profiling, Antioxidant, and Antimicrobial Activities of a Tunisian Capsicum annuum Cultivar
Authors: Grojja Yossri , Hajlaoui Hafedh , Luca Simon Vlad , Abidi Jouda , Skalicka-Woźniak Krystyna , Zouari Sami , Bouaziz Mohamed
Published: August 2023

Peppers are among the spices possessing a wide plethora of biological properties due to their excellent supply of health-related metabolites. Capsicum annuum L. (Solanaceae) is cultivated throughout Tunisia, and there is a shortage of information on the identification of the secondary metabolites in the seeds of this species as well as on their biological activities. In the present work, we intended to undertake a chemical characterization of the bioactive compounds from the hydro-methanolic seed extract of C. annuum as well as an evaluation of its broad spectrum of antimicrobial and antioxidant activities. The chemical profile was evaluated by RP-HPLC-DAD-QTOF-MS/MS, whereas the total phenol and flavonoid content, antioxidant, and antimicrobial activities were determined in in vitro assays. In this work, 45 compounds belonging to various phytochemical classes, such as organic acids (2), phenolic compounds (4 phenolic acids and 5 flavonoids), capsaicinoids (3), capsianosides (5), fatty acids (13), amino acids (1), sphingolipids (10), and steroids (2) were identified in the hydro-methanolic seed extract of C. annuum. The phenolic and flavonoid content (193.7 mg GAE/g DW and 25.1 mg QE/g DW, respectively) of the C. annuum extract correlated with the high antiradical activity (IC50 = 45.0 µg/mL), reducing power (EC50 = 61.3 µg/mL) and chelating power (IC50 = 79.0 µg/mL) activities. The hydro-methanolic seed extract showed an important antimicrobial activity against seven bacterial and four fungal strains. In fact, the inhibition zones (IZs) for bacteria ranged from 9.00 ± 1.00 mm to 12.00 ± 0.00 mm; for fungi, the IZs ranged from 12.66 ± 0.57 mm to 13.66 ± 0.57 mm. The minimal inhibition concentration and minimal bactericidal concentration values showed that the extract was more effective against fungi than bacteria.
2-Alkyl-Substituted-4-Amino-Thieno[2,3-d]Pyrimidines: Anti-Proliferative Properties to In Vitro Breast Cancer Models
Authors: Iliev Ivan , Mavrova Anelia , Yancheva Denitsa , Dimov Stefan , Staneva Galya , Nesheva Alexandrina , Tsoneva Iana , Nikolova Biliana
Published: August 2023

Thienopyrimidines are structural analogs of quinazolines, and the creation of new 2-alkyl derivatives of ethyl 4-aminothienopyrimidine-6-carboxylates for the study of their anti-proliferative properties is of great pharmacological interest. Some 2-alkyl-4-amino-thieno[2,3-d]pyrimidines 2–5 were synthesized, and their cyto- and phototoxicity against BALB 3T3 cells were established by an in vitro 3T3 NRU test. The obtained results indicate that the tested compounds are not cytotoxic or phototoxic, and that they are appropriate to be studied for their anti-proliferative and anti-tumor properties. The anti-proliferative potential of the compounds was investigated on MCF-7 and MDA-MB-231 cancer cells, as well as a MCF-10A cell line (normal human mammary epithelial cells). The most toxic to MCF-7 was thienopyrimidine 3 with IC50 13.42 μg/mL (IC50 0.045 μM), followed by compound 4 (IC50 28.89 μg/mL or IC50 0.11 μM). The thienopyrimidine 4 revealed higher selectivity to MCF-7 and lower activity (IC50 367 μg/mL i.e., 1.4 μM) than compound 3 with MCF-10A cells. With respect to MDA-MB-231 cells, ester 2 manifested the highest effect with IC50 52.56 μg/mL (IC50 0.16 μM), and 2-ethyl derivative 4 revealed IC50 62.86 μg/mL (IC50 0.24 μM). It was estimated that the effect of the substances on the cell cycle progression was due to cell cycle arrest in the G2 stage for MDA-MB-231, while arrest in G1 was detected for the estrogen (ER)-positive MCF-7 cell line. The tested compound’s effects on the change of the zeta potential in the tumorigenic cells utilized in this study were determined. The calculation which we performed of the physicochemical properties and pharmacokinetic parameters influencing the biological activity suggested high intestinal absorption, as well as drug-likeness.
Gas Chromatography–Mass Spectrometry-Based Cerebrospinal Fluid Metabolomics to Reveal the Protection of Coptisine against Transient Focal Cerebral Ischemia–Reperfusion Injury via Anti-Inflammation and Antioxidant
Authors: Zhang Junjie , Qi Ao , Liu Lulu , Cai Chun , Xu Hui
Published: August 2023

Coptisine (Cop) exerts a neuroprotective effect on central nervous system disease, particularly ischemic stroke. However, its protective mechanism is still unclear. This study aimed to investigate the protective effect of Cop on cerebral ischemia–reperfusion (IR) rats with a middle cerebral artery occlusion model by integrating a gas chromatography–mass spectrometry (GC–MS)-based metabolomics approach with biochemical assessment. Our results showed that Cop could improve neurobehavioral function and decrease the ischemia size in IR rats. In addition, Cop was found to decrease inflammatory mediators (e.g., prostaglandin D2 (PGD2) and tumor necrosis factor-α (TNF-α) and attenuate oxidative stress response (e.g., increase the superoxide dismutase (SOD) expression and decrease 8-iso-PGF2α level). Furthermore, the GC-MS-based cerebrospinal fluid (CSF) metabolomics analysis indicated that Cop influenced the level of glycine, 2,3,4-trihydroxybutyric acid, oleic acid, glycerol, and ribose during IR injury. Cop exhibited a good neuroprotective effect against cerebral IR injury and metabolic alterations, which might be mediated through its antioxidant and anti-inflammatory properties.
Synthesis of Bis-Chalcones and Evaluation of Its Effect on Peroxide-Induced Cell Death and Lipopolysaccharide-Induced Cytokine Production
Authors: Tom Alby , Jacob Jisha , Mathews Manoj , Rajagopal Rajakrishnan , Alfarhan Ahmed , Barcelo Damia , Narayanankutty Arunaksharan
Published: August 2023

Plant secondary metabolites are important sources of biologically active compounds with wide pharmacological potentials. Among the different classes, the chalcones form integral pharmacologically active agents. Natural chalcones and bis-chalcones exhibit high antioxidant and anti-inflammatory properties in various experiments. Studies are also underway to explore more biologically active bis-chalcones by chemical synthesis of these compounds. In this study, the effects of six synthetic bis-chalcones were evaluated in intestinal epithelial cells (IEC-6); further, the anti-inflammatory potentials were studied in lipopolysaccharide-induced cytokine production in macrophages. The synthesized bis-chalcones differ from each other first of all by the nature of the aromatic cores (functional group substitution, and their position) and by the size of a central alicycle. The exposure of IEC-6 cells to peroxide radicals reduced the cell viability; however, pre-treatment with the bis-chalcones improved the cell viability in these cells. The mechanism of action was observed to be the increased levels of glutathione and antioxidant enzyme activities. Further, these bis-chalcones also inhibited the LPS-stimulation-induced inflammatory cytokine production in RAW 264.7 macrophages. Overall, the present study indicated the cytoprotective and anti-inflammatory abilities of synthetic bis-chalcones.
Multicomponent Reactions between Heteroatom Compounds and Unsaturated Compounds in Radical Reactions
Authors: Ogawa Akiya , Yamamoto Yuki
Published: August 2023

In this mini-review, we present our concepts for designing multicomponent reactions with reference to a series of sequential radical reactions that we have developed. Radical reactions are well suited for the design of multicomponent reactions due to their high functional group tolerance and low solvent sensitivity. We have focused on the photolysis of interelement compounds with a heteroatom–heteroatom single bond, which readily generates heteroatom-centered radicals, and have studied the photoinduced radical addition of interelement compounds to unsaturated compounds. First, the background of multicomponent radical reactions is described, and basic concepts and methodology for the construction of multicomponent reactions are explained. Next, examples of multicomponent reactions involving two interelement compounds and one unsaturated compound are presented, as well as examples of multicomponent reactions involving one interelement compound and two unsaturated compounds. Furthermore, multicomponent reactions involving intramolecular cyclization processes are described.
Interface-Based Design of High-Affinity Affibody Ligands for the Purification of RBD from Spike Proteins
Authors: Song Siyuan , Shi Qinghong
Published: August 2023

The outbreak of coronavirus disease 2019 (COVID-19) has sparked an urgent demand for advanced diagnosis and vaccination worldwide. The discovery of high-affinity ligands is of great significance for vaccine and diagnostic reagent manufacturing. Targeting the receptor binding domain (RBD) from the spike protein of severe acute respiratory syndrome-coronavirus 2, an interface at the outer surface of helices on the Z domain from protein A was introduced to construct a virtual library for the screening of ZRBD affibody ligands. Molecular docking was performed using HADDOCK software, and three potential ZRBD affibodies, ZRBD-02, ZRBD-04, and ZRBD-07, were obtained. Molecular dynamics (MD) simulation verified that the binding of ZRBD affibodies to RBD was driven by electrostatic interactions. Per-residue free energy decomposition analysis further substantiated that four residues with negative-charge characteristics on helix α1 of the Z domain participated in this process. Binding affinity analysis by microscale thermophoresis showed that ZRBD affibodies had high affinity for RBD binding, and the lowest dissociation constant was 36.3 nmol/L for ZRBD-07 among the three potential ZRBD affibodies. Herein, ZRBD-02 and ZRBD-07 affibodies were selected for chromatographic verifications after being coupled to thiol-activated Sepharose 6 Fast Flow (SepFF) gel. Chromatographic experiments showed that RBD could bind on both ZRBD SepFF gels and was eluted by 0.1 mol/L NaOH. Moreover, the ZRBD-07 SepFF gel had a higher affinity for RBD. This research provided a new idea for the design of affibody ligands and validated the potential of affibody ligands in the application of RBD purification from complex feedstock.
Exploring the Interaction of Cosmic Rays with Water by Using an Old-Style Detector and Rossi’s Method
Authors: Arcani Marco , Liguori Domenico , Grana Andrea
Published: August 2023

Cosmic ray air showers are a phenomenon that can be observed on Earth when high-energy particles from outer space collide with the Earth’s atmosphere. These energetic particles in space are called primary cosmic rays and consist mainly of protons (about 89%), along with nuclei of helium (10%) and heavier nuclei (1%). Particles resulting from interactions in the atmosphere are called secondary cosmic rays. The composition of air showers in the atmosphere can include several high-energy particles such as mesons, electrons, muons, photons, and others, depending on the energy and type of the primary cosmic ray. Other than air, primary cosmic rays can also produce showers of particles when they interact with any type of matter; for instance, particle showers are also produced within the soil of planets without an atmosphere. In the same way, secondary cosmic particles can start showers of tertiary particles in any substance. In the 1930s, Bruno Rossi conducted an experiment to measure the energy loss of secondary cosmic rays passing through thin metal sheets. Surprisingly, he observed that as the thickness of the metal sheets increased, the number of particles emerging from the metal also increased. However, by adding more metal sheets, the number of particles eventually decreased. This was consistent with the expectation that cosmic rays were interacting with the atoms in the metals and losing energy to produce multiple secondary particles. In this paper, we describe a new–old approach for measuring particle showers in water using a cosmic ray telescope and Rossi’s method. Our instrument consists of four Geiger–Müller tubes (GMT) arranged to detect muons and particle showers. GMT sensors are highly sensitive devices capable of detecting electrons and gamma rays with energies ranging from a few tens of keV up to several tens of MeV. Since Rossi studied the effects caused by cosmic rays as they pass through metals, we wondered if the same process could also happen in water. We present results from a series of experiments conducted with this instrument, demonstrating its ability to detect and measure particle showers produced by the interaction of cosmic rays in water with good confidence. To the best of our knowledge, this experiment has never been conducted before. Our approach offers a low-cost and easy-to-use alternative to more sophisticated cosmic ray detectors, making it accessible to a wider range of researchers and students.
Depression Events Associated with Proton-Pump Inhibitors in Postmarketing Drug Surveillance Data
Authors: Makunts Tigran , Joulfayan Haroutyun , Ta Kenneth , Abagyan Ruben
Published: August 2023

Proton-pump inhibitors, PPIs, are widely prescribed and are available over the counter for prolonged reduction of stomach acid production and related disorders. PPIs irreversibly inhibit the hydrogen/potassium ATPase in gastric parietal cells. Recent retrospective studies have described an association between PPI use and depression. However, there is conflicting evidence that PPI therapy improves depressive symptoms. Considering the widespread use and over-the-counter availability of these drugs, further investigation into depression adverse event was warranted with a larger-scale postmarketing set of reports. Here we analyzed over 125,923 reports from the FDA Adverse Event Reporting System consisting of PPI and histamine-2 receptor antagonist monotherapy records and found a statistically significant association between use of PPIs and depression. Additionally, we analyzed each of the six currently marketed PPIs individually and observed the association with the depression adverse reaction for all of them.
The Impact of an Antimicrobial Stewardship Clinical Pharmacy Specialist on Antimicrobial Days of Therapy through Education Driven Policies, Procedures, and Interventions
Authors: Martinez Yolanda G. , Tran MaiCuc , Roduta Thomas , Lam Susan , Price Todd , Stramel Stefanie
Published: August 2023

The primary goal of antimicrobial stewardship is to improve patient outcomes and minimize the consequences of antibiotic use. Prospective audit and feedback cannot always be performed by an antimicrobial stewardship program member which is where policies, procedures and education can aid interventions. The purpose of this study was to evaluate the impact on antimicrobial days of therapy due to a dedicated clinical pharmacy specialist primarily responsible for developing policies and procedures and providing education. A pre-intervention and post-intervention retrospective analysis of antimicrobial days of therapy from September 2019–May 2020 and July 2020–March 2021 was performed. Inclusion criteria consisted of adults receiving IV vancomycin, azithromycin, meropenem, ciprofloxacin, and/or levofloxacin. Excluded criteria consisted of documented interventions that were not related to implemented policies and procedures or performed education and patients receiving antimicrobial surgical prophylaxis. The primary outcome was antimicrobial days of therapy. An average of 3.47 ± 2.46 days (pre-intervention, n = 203) and 3.21 ± 2.52 days (post-intervention, n = 203) were observed for the primary outcome (p < 0.04182). Pharmacists performed 75 interventions pre-intervention and 102 interventions post-intervention (p = 0.0092). The implementation of a dedicated antimicrobial stewardship clinical pharmacy specialist responsible for developing policies, procedures, and education successfully reduced antimicrobial days of therapy and documented interventions.
Enhancing the Steady-State Entanglement between a Laguerre–Gaussian-Cavity Mode and a Rotating Mirror via Cross-Kerr Nonlinearity
Authors: Lai Guilin , Huang Sumei , Deng Li , Chen Aixi
Published: August 2023

Quantum entanglement will play an important role in future quantum technologies. Here, we theoretically study the steady-state entanglement between a cavity field and a macroscopic rotating mirror in a Laguerre–Gaussian-(LG)-cavity optomechanical system with cross-Kerr nonlinearity. Logarithmic negativity is used to quantify the steady-state entanglement between the cavity and mechanical modes. We analyze the impacts of the cross-Kerr coupling strength, the cavity detuning, the input laser power, the topological charge of the LG-cavity mode, and the temperature of the environment on the steady-state optomechanical entanglement. We find that cross-Kerr nonlinearity can significantly enhance steady-state optomechanical entanglement and make steady-state optomechanical entanglement more robust against the temperature of the thermal environment.
Paradigm of Well-Orchestrated Pharmacokinetic Properties of Curcuminoids Relative to Conventional Drugs for the Inactivation of SARS-CoV-2 Receptors: An In Silico Approach
Authors: Srivastava Akhileshwar Kumar , Singh Divya , Yadav Priya , Singh Monika , Singh Sandeep Kumar , Kumar Ajay
Published: August 2023

To cure SARS-CoV-2 infection, the repurposing of conventional antiviral drugs is currently advocated by researchers, though their action is not very effective. The present study, based on in silico methods, was intended to increase the therapeutic potential of conventional drugs: hydroxychloroquine (HCQ), favipiravir (FAV), and remdesivir (REM) by using curcuminoids like curcumin (CUR), bisdemethoxycurcumin (BDMC), and demethoxycurcumin (DMC) as adjunct drugs against SARS-CoV-2 receptor proteins, namely main protease (Mpro) and the S1 receptor-binding domain (RBD). The curcuminoids exhibited similar pharmacokinetic properties to the conventional drugs. The webserver (ANCHOR) predicted greater protein stability for both receptors with a disordered score (<0.5). The molecular docking study showed that the binding energy was highest (−27.47 kcal/mol) for BDMC toward Mpro receptors, while the binding energy of CUR (−20.47 kcal/mol) and DMC (−20.58 kcal/mol) was lower than that of HCQ (−24.58 kcal/mol), FAV (−22.87 kcal/mol), and REM (−23.48 kcal/mol). In the case of S1-RBD, CUR had the highest binding energy (−38.84 kcal/mol) and the lowest was in FAV (−23.77 kcal/mol), whereas HCQ (−35.87 kcal/mol) and REM (−38.44 kcal/mol) had greater binding energy than BDMC (−28.07 kcal/mol) and DMC (−30.29 kcal/mol). Hence, this study envisages that these curcuminoids could be employed in combination therapy with conventional drugs to disrupt the stability of SARS-CoV-2 receptor proteins.
The Synthesis of BODIPY-TKI Conjugates and Investigation of Their Ability to Target the Epidermal Growth Factor Receptor
Authors: Dhingra Simran , Shrestha Prajesh , Chowdhury Arpan , Zhou Zehua , Jois Seetharama D. , Vicente Maria da Graça H.
Published: August 2023

A near-IR BODIPY was covalently conjugated via its isothiocyanate groups to one or two Erlotinib molecules, a known tyrosine kinase inhibitor (TKI), via triethylene glycol spacers, to produce two novel BODIPY-monoTKI and BODIPY-diTKI conjugates. The ability of these conjugates to target the intracellular domain of the epidermal growth factor receptor (EGFR) was investigated using molecular modeling, surface plasma resonance (SPR), EGFR kinase binding assay, time-dependent cellular uptake, and fluorescence microscopy. While both the BODIPY-monoTKI and the BODIPY-diTKI conjugates were shown to bind to the EGFR kinase by SPR and accumulated more efficiently within human HEp2 cells that over-express EGFR than BODIPY alone, only the BODIPY-monoTKI exhibited kinase inhibition activity. This is due to the high hydrophobic character and aggregation behavior of the BODIPY-diTKI in aqueous solutions, as shown by fluorescence quenching. Furthermore, the competition of the two Erlotinibs in the diTKI conjugate for the active site of the kinase, as suggested by computational modeling, might lead to a decrease in binding relative to the monoTKI conjugate. Nevertheless, the efficient cellular uptake and intracellular localization of both conjugates with no observed cytotoxicity suggest that both could be used as near-IR fluorescent markers for cells that over-express EGFR.
Electron Beams on the Brillouin Zone: A Cohomological Approach via Sheaves of Fourier Algebras
Authors: Zafiris Elias , Müller Albrecht von
Published: August 2023

Topological states of matter can be classified only in terms of global topological invariants. These global topological invariants are encoded in terms of global observable topological phase factors in the state vectors of electrons. In condensed matter, the energy spectrum of the Hamiltonian operator has a band structure, meaning that it is piecewise continuous. The energy in each continuous piece depends on the quasi-momentum which varies in the Brillouin zone. Thus, the Brillouin zone of quasi-momentum variables constitutes the base localization space of the energy eigenstates of electrons. This is a continuous topological parameter space bearing the homotopy of a torus. Since the base localization space has the homotopy of a torus, if we vary the quasi-momentum in a direction, when the edge of the zone is reached, we obtain a closed path. Then, if we lift this loop from the base space to the sections of the sheaf-theoretic fibration induced by the localization of the energy eigenfunctions, we obtain a global topological phase factor which encodes the topological structure of the Brillouin zone. Because it is homotopically equivalent to a torus, the global phase factor turns out to be quantized, taking integer values. The experimental significance of this model stems from the recent discovery that there are observable global topological phase factors in fairly ordinary materials. In this communication, we show that it is the unitary representation theory of the discrete Heisenberg group in terms of commutative modular symplectic variables, giving rise to a joint commutative representation space endowed with an integral and Z2-invariant symplectic form that articulates the specific form of the topological conditions characterizing both the quantum Hall effect and the spin quantum Hall effect under a unified sheaf-theoretic cohomological framework.
Anisotropy of Self-Correlation Level Contours in Three-Dimensional Magnetohydrodynamic Turbulence
Authors: Yang Liping , He Jiansen , Wang Xin , Wu Honghong , Zhang Lei , Feng Xueshang
Published: August 2023

MHD turbulence is considered to be anisotropic owing to the presence of a magnetic field, and its self-correlation anisotropy has been unveiled by solar wind observations. Here, based on numerical results of compressible MHD turbulence with a global mean magnetic field, we explore variations of the normalized self-correlation function’s (NCF) level contours with the scale as well as their evolution. The analyses reveal that the NCF’s level contours tend to elongate in the direction parallel to the mean magnetic field, and the elongation becomes weak with decreasing intervals. These results are consistent with slow solar wind observations. The less anisotropy of the NCF’s level contours with the shorter intervals can be produced by the fact that coherent structures stretch more along the parallel direction at the long intervals than at the short intervals. The analyses also disclose that as the simulation time builds up, the NCF’s level contours change thinner and thinner, and the anisotropy of the NCF’s level contours grows, which can be caused by the break of large coherent structures into small ones. The increased self-correlation anisotropy with time foretells that the self-correlation anisotropy of solar wind turbulence enlarges with the radial distance, which needs to be tested against observations by using Parker Solar Probe (PSP) measurements.
Hartree–Fock Calculations in Semi-Infinite Matter with Gogny Interactions
Authors: Davesne Dany , Pastore Alessandro , Navarro Jesus
Published: August 2023

Hartree–Fock equations in semi-infinite nuclear matter for finite range Gogny interactions are presented together with a detailed numerical scheme to solve them. The value of the surface energy is then extracted and given for standard Gogny interactions.
Les aménagements « bois-pierre » de la Marronède centrale (Fos-sur-Mer) : premières études archéologique et dendro-archéologique.
Authors: Fontaine Souen , Borel Laurent , El Amouri Mourad , Greck Sandra , Guibal Frédéric , Marty Frédéric , Ferreira Domínguez Alba
Published: August 2023

Les recherches sous-marines conduites au large de la digue de la Marronède, à Fos-sur-Mer, ont mis en évidence un aménagement composé d’alignements de pieux en chêne de grandes dimensions, régulièrement espacés, mis en place entre le milieu du Ier s. et le milieu du IIe s. La structure paraît avoir été implantée à proximité d’un rivage dont le sol, humide, est stabilisé par un enrochement de moellons et de grands blocs taillés. L’étude archéologique et dendrologique suggère qu’il s’agit d’un aménagement de qualité de grande ampleur dont la fonction, bien que non encore clairement établie, s’intègre dans le complexe portuaire de Fos.
Esclaves et affranchis à Mostyn Hall : le parcours de quatre inscriptions funéraires depuis Narbonne et Rome
Authors: Moisand Marie
Published: August 2023

Quatre inscriptions antiques appartiennent aux collections de Mostyn Hall (Mostyn, Pays de Galles). Deux d’entre elles proviennent de Narbonne où elles ont été vendues au XVIIIe s. Les deux autres proviennent de Rome. Les textes sont de nature funéraire et concernent un milieu servile ou affranchi. La confirmation du lieu de conservation actuel des inscriptions fournit l’occasion d’un commentaire des textes et de leur support. Le parcours de ces quatre plaques funéraires impose aussi de s’interroger sur les circonstances de leur vente pour s’assurer de leur origine. L’étude spécifique des blocs narbonnais présente enfin un double intérêt. Elle confirme tout d’abord une influence italienne marquée, bien connue par ailleurs. Elle augmente ensuite le nombre des épitaphes gravées sur un support de marbre de petites dimensions connues à Narbonne. Si on les y devine nombreuses, elles ont très souvent été perdues faute d’avoir été remployées lors de l’édification des remparts de la ville.
Le site de La Grangette à Vinassan (Aude). Évolution d’un établissement rural précoce près de Narbonne, du IIe s. av. au Ier s. ap. J.-C.
Authors: Le Roy Ludovic , Malignas Adrien , Galy Jessica , Carrato Charlotte , Gaillard Arnaud , Bénézet Jérôme , Sabrié Raymond
Published: August 2023

Le site de La Grangette à Vinassan est installé à environ 8 km au nord-est de Narbonne. Malgré un arasement prononcé, les vestiges mis au jour permettent de suivre son évolution entre le courant du IIe s. av. J.-C. et le Ier s. ap. J.-C. À la fin du IIe s. av. J.-C., une première occupation délimitée par un important fossé fait place à un établissement couvrant près de 1 800 m2. L’édifice richement doté sur le plan architectural apparait comme un cas unique en Gaule méridionale pour l’époque considérée. Il se compose de plusieurs corps de bâtiment répartis autour d’une cour centrale organisée comme un péristyle. Bordée de trois colonnades, elle livre plusieurs aménagements hydrauliques dont un vaste bassin. La distribution et la nature des pièces rappellent les villae et domus italiennes de la fin de la République et interrogent sur le statut et l’origine du commanditaire. Après son démantèlement, un nouvel établissement est construit à l’époque augustéenne. Beaucoup plus modeste, celui-ci semble tourné vers la viticulture.
La basilique de Saint-Ferréol et l’église paroissiale de Saint-Romain-en-Gal (Rhône).
Authors: Reynaud Jean-François , Blain Sophie , Delomier Chantal , Flammin Anne , Guibert Pierre , Helly Benoît , Lanos Philippe
Published: August 2023

L’actuelle église paroissiale de Saint-Romain-en-Gal est un des rares édifices de l’Antiquité tardive encore conservé en élévation. Son plan, sa technique de construction, les tombes et les inscriptions, les résultats des analyses en luminescence et archéomagnétisme donnent, pour sa construction, une datation entre le Ve et le VIIe s. Cette datation haute pose à nouveau la question des lieux de culte qui auraient abrité la sépulture du martyr viennois Ferréol. Après relecture des données archéologiques et des textes anciens, nous estimons que la grande basilique funéraire du bord du Rhône, fouillée de façon très partielle en 1977, pourrait avoir été construite au milieu du Ve s. et nous l’appellerons Saint-Ferréol 1, en excluant l’hypothèse du mausolée proche du musée. Si l’on en croit Grégoire de Tours (HF, II, 33‑34), cette basilique proche du fleuve fut détruite par une crue du Rhône. Peu avant 473, elle fut reconstruite par l’évêque de Vienne Mamert, soucieux de maintenir le culte martyrial. L’actuelle église paroissiale de Saint-Romain-en-Gal serait cette deuxième construction, installée par prudence sur une terrasse à l’abri des inondations (Saint-Ferréol 2).
L’aqueduc romain d’Aix-en-Provence / Traconnade.
Authors: Fino Bernard , Fuhry Marc
Published: August 2023

Cet article dresse le bilan de plusieurs missions de prospection/ inventaire sur l’aqueduc aixois dit de «Traconnade » à l’occasion desquelles ont été répertoriés plus de deux cent vestiges dont une cinquantaine de regards. Plus de 3 km du canal ont pu être visités de l’intérieur. Le tracé de l’aqueduc est ainsi précisé sur la majeure partie de son parcours d’environ 31,5 km, de Jouques à Aix, en passant par Peyrolles, Meyrargues et Venelles. Une attention particulière est portée aux techniques de construction des ouvrages, aux empreintes des planches de coffrage et aux regards. Le relevé DGPS du profil altimétrique de cet ouvrage présente une faible pente sur ses premiers 19 km en val de Durance, avant le grand tunnel de Venelles, ouvrage unique en Gaule par sa longueur d’environ 8,4 km et sa grande profondeur. Considérant les concrétions observées, le débit habituel de l’aqueduc est estimé de 150 à 175 l/ s.
Des péristyles corinthiens dans les domus de Vienna : note sur des fragments d’architecture découverts à Sainte-Colombe (69) .
Authors: Ribolet Mathieu , Clément Benjamin
Published: August 2023

In 2016 and 2017, two preventive archaeological excavations at Sainte-Colombe (69) revealed the remains of rich peristyle houses belonging to the suburbium of the Roman colony of Vienne. Numerous fragments of architectural decorations have been extracted, including pieces of corinthian capitals, which are rarely found in a context of Gallo-Roman housing. Reconstructing and stylistically analyzing these capitals result in dates between the Flavian period and the end of the 2nd century AD and thus confirm that Sainte-Colombe houses were decorated through several phases. From a broader point of view, these few pieces raise some interesting questions about using corinthian order into gallo-roman peristyles and the significance of such a choice of ornamentation for proprietaries.
La tête de « Jupiter capitolin » de Fréjus (Forum Iulii).
Authors: Lemoine Yvon , Blanchard Florian
Published: August 2023

The uncovering of part of the remains of the Porte Dorée thermal baths in 1821 is part of a pioneering period in Fréjus, which between 1803 and 1829 saw a first series of methodical archaeological excavations. The unearthing of the head of a middle-aged man in white marble in the filling levels of the natatio of these public baths opened a new chapter in the religious and civic history of the Roman city. Now considered a representation of Capitoline Jupiter, this first-rate sculpted work is studied here in a comprehensive way, two hundred years after its discovery.
Les bâtiments de stockage de denrées agricoles tardo-antiques de la Barrière 2 à Servian (Hérault)
Authors: Canillos Thibaud
Published: August 2023

En 2017, la fouille préventive du site de la Barrière 2 sur la commune de Servian a permis de mettre en évidence un bâtiment antique de grandes dimensions, comportant des bases maçonnées. Celui-ci est structuré par deux murs d’orientation nord-est/ sud-ouest, cinq massifs maçonnés et huit fosses de spoliations en lien avec d’autres massifs. Ceux-ci ont la même orientation que les murs et semblent faire partie intégrante d’un même ensemble. Ce plan est incomplet, se poursuivant au sud et au nord de l’emprise de fouille. Sa superficie minimale est de 375 m ² et il a dû subir au moins une extension et/ ou une réfection. En effet, on observe des recoupements entre plusieurs de ces massifs, puis des spoliations au moment de l’abandon du site. Au moins deux états ont été documentés, le premier prenant place dans un large IVe s., alors que le second semble être abandonné à partir du milieu du Ve s. Le plan de cet édifice pourrait le rapprocher des grands greniers à piliers internes, surtout connus dans le nord de la Gaule, qui ont la particularité de posséder une superficie importante et des murs à contreforts.
Models of formation of professional competence of future teachers
Authors: Marushko Larysa , Hura Antonina , Bryk Roman , Baboval Nadiia , Karabin Oksana
Published: August 2023

The aim of the work was to develop and determine the effectiveness of the model for building future teachers’ professional competence. The aim was achieved through the use of calculations of the efficiency coefficient, the coefficient of practical effectiveness, the Cohen’s kappa coefficient. It was established that the interactive approach, which was used before the beginning of studies among 15% of students, enabled obtaining a higher level of their knowledge. The traditional education system made it possible to achieve a high level of knowledge among 31% of students. The development of a model for building professional competence of future secondary school teachers provided for the use of non-standard approaches and digital technologies (Coursera, Prometheus). It was found that students showed a high quality of material presentation (3.41) and a lower level of organization of the educational process (0.91) during teaching practice. The results contributed to highly effective knowledge of ecology, informatics, pedagogy/educational methodology acquired by high school students. It was determined that 62% of students developed high professional competence skills. The practical significance of the work is the developed system of future teachers’ professional competence through the introduction of non-standard approaches. The prospects of the research may be related to the provision of options for increasing the level of professional competence for future teachers of secondary and higher educational institutions.
Development of time perspective in nenets, Sami and Russian adolescents: A comparative analysis
Authors: Flotskaya Natalia , Aryabkina Irina , Bulanova Svetlana , Ponomareva Maria , Flotskiy Nikolay
Published: August 2023

This paper is concerned with the issue of studying specific features of the development of time perspective in adolescents representing different ethnic groups living in the North of Russia. The study includes a comparative analysis of the development of time perspective in Nenets, Sami, and ethnic Russian male and female adolescents.
The current article presents the results of an empirical study conducted using the Zimbardo Time Perspective Inventory. The respondents in the empirical study were 99 Nenets adolescents aged 12-15 years (54 boys and 45 girls); 79 Sami adolescents aged 12-15 years (41 boys and 38 girls); 121 ethnic Russian adolescents aged 12-15 years (63 boys and 58 girls).
The comparative analysis of the development of time perspective in Nenets, Sami, and ethnic Russian adolescents has shown the presence of similar trends characteristic of the age group in general, and specific features at the same time. The results of the study enrich the scientific understanding of the phenomenon of time perspective, supplement and expand the understanding of the process of personality formation in representatives of different ethnic groups living in the North of Russia. The identified features of time perspective in adolescents will help to supplement the programs of psychological assistance and support for adolescents in the aspect of building life strategies, implementing capabilities of forecasting life prospects and managing time resources.
Entre la lengua, el método y la selección de modelos: la relación entre la escritura teológica y la búsqueda de la unidad en el pensamiento de Jean Gerson
Authors: Micali Luciano
Published: August 2023

La búsqueda de la unidad en el ámbito doctrinal, espejo e instrumento de la unidad de la Iglesia, es un elemento recurrente en la obra de Jean Gerson (1363 - 1429), renombrado teólogo y canciller de la Universidad de París entre el siglo XIV y el XV. La insistencia sobre el concepto de unidad es transmitida por una constante reflexión sobre el rol y sobre el modo de la escritura teológica. Gerson identifica métodos precisos y modelos a seguir con el fin de explicar algunas oscuridades de la Escritura con claridad y precisión, y sin riesgo para la integridad de la doctrina. Parte fundamental de la reflexión sobre la escritura teológica es la discusión sobre la posibilidad de usar la lengua vulgar, una posibilidad que el canciller parisino niega de forma lapidaria, estigmatizando la confusión lingüística que inevitablemente conduce no solo a la incomprensión recíproca, sino a la ruptura de una correspondencia entre términos y conceptos que hunde sus raíces en una consolidada y plurisecular tradición teológica en latín. El presente artículo se propone estudiar la reflexión de Gerson sobre la lengua, sobre los métodos y sobre la selección de los modelos en el ámbito de la escritura teológica académica, en el marco más amplio de la búsqueda de la unidad en el ámbito doctrinal, elemento necesario para perseguir la unidad de la Iglesia tout court.
Graphene-Supported Sc
2
O
3
/TiO
2
for Superior Catalysis on Hydrogen Sorption Kinetics of MgH
2
Authors: Huang Haixiang , Chen Jinting , Xu Tingting , Lv Yujie , Liu Bogu , Zhang Bao , Yuan Jianguang , Wu Ying
Published: August 2023

Complex metal oxide catalysts greatly accelerate the hydrogen sorption rates in the magnesium hydride system. In this study, the graphene-supported Sc
2
O
3
/TiO
2
catalyst is synthesized by means of a simple method, and a surprisingly synergetic effect of the Sc
2
O
3
-TiO
2
cocatalyst on the hydrogen storage performance of MgH
2
is observed. The MgH
2
-Sc
2
O
3
/TiO
2
@Gn composite starts to release hydrogen at 140 °C and reaches the peak dehydrogenation temperature at 239.9 °C. It absorbs 6.55 wt% of H
2
in 1 min and desorbs 5.71 wt% of H
2
in 10 min at 300 °C, showing excellent hydrogen absorption and desorption performance. Furthermore, with the decrease of the grain size and changes in the structure, the activity of the catalyst is greatly improved. The low-valent titanium and scandium and oxygen vacancies formed in the process of dehydrogenation facilitate hydrogen diffusion and electron transfer, and further improve the kinetic performance of the Mg/MgH
2
-Sc
2
O
3
/TiO
2
@Gn system. This study aims to provide insights into studying complex metal oxides as catalysts to improve hydrogen storage performance, and shed light on other catalysis-related research.
Peningkatan Kapasitas Guru Dalam Pengembangan Media Pembelajaran Unsynchronous Learning
Authors: Yuana Kumara Ari , Rahayu Dwi , Mulyatun Sri , Widowati Anik Sri
Published: August 2023

The pandemic period led to changes in learning methods. One of the learning methods that are effective now is the direct learning method (Synchronous Learning) and the indirect method (Unsynchronous Learning). Perambanan Social Vocational High School 1 has developed the learning system but has yet to maximize learning media development. Therefore, there is a need for training and workshops to increase teachers' knowledge to solve the problems encountered related to making learning media. The service is carried out through several stages: identifying activities, planning and implementing activities, follow-up and evaluation, and preparing reports. The results of the service show that participants not only have the ability to develop learning media but also have a deeper understanding of the benefits of technology in learning. The teachers involved are expected to strengthen their abilities in developing creative and relevant learning content according to the needs of students. This effort can potentially improve the quality of learning, expand accessibility for students to learn flexibly, and present a more interactive and exciting learning experience.
Pelatihan Penggunaan Mendeley Reference Dalam Penulisan Karya Ilmiah
Authors: Fajrianti Fajrianti , Kaif Sitti Hermayanti
Published: August 2023

Writing scientific papers is an essential foundation in the academic sphere, requiring researchers, students, and academics to manage, refer to, and cite various sources that support their arguments and findings. Emerging as a solution to this challenge, Mendeley Reference has the potential to change the way writers manage references in the context of higher education. This Community Service Activity (PKM) aims to provide a more comprehensive understanding to students, especially those in the 7th semester of the PGSD major at the Teaching and Education Faculty of Buton Muslim University, regarding the benefits of using the Mendeley application in writing scientific assignments. This PKM is carried out through three stages: preparation, implementation, and evaluation. The evaluation results showed that most participants had a good understanding, but some required further training. The positive impact of the training can be seen in the academic and professional development of the participants. Therefore, as a follow-up, practical exercises will be intensified, increased structured discussions between participants and presenters, and gathering input from participants for future improvements. Overall, this training significantly contributes to providing students with essential skills in scientific writing and better preparation for future academic and professional challenges.
Pendampingan Peternak Kelinci Dalam Strategi Pemasaran Melalui Media Sosial Guna Meningkatkan Ekonomi
Authors: Fahrudin Fahrudin , Adi Pranata Mohammad Sofyan
Published: August 2023

This activity is carried out based on problems obtained in the field, namely the lack of marketing strategies through social media as well as the low economic income of the community from rabbit livestock products. This activity aims to provide knowledge and experience in promoting rabbit livestock products through social media to improve the community's economy. Activities are carried out in stages, starting from the planning stage through implementation and evaluation. The results of this assistance provide experience to the team, which can work together with the community, especially the farmers. It is beneficial for the farmers themselves to increase their knowledge and ability to promote their livestock through social media. Making farmers able to promote and increase the scope of the target market through social media Increase the creativity of farmers in promoting their livestock products. Furthermore, farmers can independently promote and market their livestock products in their respective cages so that they can increase the sales of livestock products optimally.
Sosialisasi Budikdamber Guna Menjaga Kestabilan Ketahanan Pangan Keluarga
Authors: Lusianingrum Farah Putri Wenang , Alfian Iqbal , Maulana Iqbal , Zahwa ST , Wati Helmalia , Abhinaya Reswara Faza , Hanifah Ayu Nur’aliyah , Gantara Gerald Dewa , Akbar Muhibudin , Firdausiah Salsabila
Published: August 2023

The increase in the unemployment rate in Bojong Pandan Village after the Covid-19 pandemic has threatened the stability of family food security. This condition threatens to make families in Bojong Pandan Village experience difficulties in meeting their basic needs through food. Budikdamber innovation is a solution to maintain family food security stability. However, the community still needs to gain knowledge and skills regarding Budikdamber, so there is a need for synergy between the village government and universities through community service activities. This service aims to increase the participant's knowledge and skills regarding Budikdamber. Implementation methods to support the achievement of the goals of this service include surveys, preparation, implementation, and evaluation. The results obtained from this community service activity were an increase in the participants' knowledge of 47.47%, and all participants could practice the tutorial activities for making Budikdamber. Follow-up of this activity will be routine monitoring at least once a month and innovating variations on fish and plant species other than catfish and water spinach.
Edukasi Pengenalan Stunting Pada Remaja Putri
Authors: Muchtar Febriana , Rejeki Sri , Elvira Ilian , Hastian Hastian
Published: August 2023

Stunting is a chronic nutritional problem that prevention must be done earliest. Therefore, information about stunting must be given to adolescent girls to prepare them to become prospective mothers with good nutrition and health status. The purpose of the community service is to provide information, knowledge, and understanding to adolescent girls about stunting as one of the nutritional problems in Indonesia. Community service is carried out by counseling with lectures and discussion methods. The school highly appreciates the community service activity. Counseling can increase the knowledge of adolescent girls about stunting. The material about stunting can be understood by adolescent girls marked by appropriate answers to questions during the discussion. Teenage girls are expected to be able to implement behaviors that can improve their health to prevent stunting from an early stage and can disseminate information.
Doğal Dil İşleme Teknikleri Kullanarak E-Ticaret Kullanıcı İncelemelerinde Özellik Tabanlı Duygu Analizi
Authors: ASLAN Serpil
Published: August 2023

Son yıllarda her zaman için her yerden ürün satın alma kolaylığı sağladığı ve ürünleri satın alan diğer kullanıcıların incelemelerinden kolayca ürün karşılaştırması sağladığından dolayı E-ticaret sitelerinden yapılan satın alma işlemleri oldukça artmıştır. E-Ticaret sitelerinde satılan ürünlerdeki kullanıcı puanları ve yorumları ürünlerin satın alma sayısını büyük ölçüde etkilemektedir. Müşteri incelemeleri aynı zamanda E-ticaret platformları için büyük miktarda metinsel veri üretmektedir. Üretilen bu verilerin analiz edilmesi satıcıların müşteri beklentilerini anlamalarını sağlayacakları için satışlarını da arttıracaktır. Bazı durumlarda müşteri değerlendirmeleri ve puanlamaları sadece ürünle ilgili olmayıp ürünün teslimatı gibi farklı konularla ilgili de olabilir. Bu durum diğer müşteriler için alışveriş riski oluşmasına sebep olmaktadır. Doğal Dil İşleme (DDİ) teknikleri aracılığıyla yapılacak olan duygu analizi, müşteriler tarafından herhangi bir ürün ile ilgili yapılan herkese açık incelemelerin analiz edilmesine odaklanır. Özellik tabanlı duygu analizi alanı, belirleyici önerilerde bulunmak için müşteri yorumlarında bulunan çeşitli görüşleri kategorize eder. Bu çalışmada E-ticaret platformlarından elde edilmiş müşteri yorumları veri setinde TF-IDF ve Word2Vec teknolojileri aracılığıyla müşteri incelemelerindeki özellikler tespit edilir. Daha sonra, tespit edilen her bir özellikle ilgili duygu ifadeleri incelenir. Çalışma, hem E-ticaret platformlarına hem de satıcılara mal ve hizmetlerini iyileştirebilmeleri için ışık tutacaktır. Aynı zamanda müşterilere alışverişlerinde özellik düzeyinde detaylı inceleme olanağı sağlayacaktır.