bluuebunny/crossref_metadata_2025 huggingface dataset:
IDENTIFICAÇÃO DE TENDÊNCIAS NO CONFORTO TÉRMICO NA REGIÃO NORTE DO BRASIL: ESTUDO DE CASO EM MANAUS-AM/ Identification of thermal comfort trends in the region north do brazil: case study in Manaus-AM
Authors: Mandú Tiago Bentes , Gomes Ana Carla Dos Santos
Published: July 2019

O conforto térmico é o parâmetro meteorológico que mensura o quão agradável é o ambiente levando em consideração fatores ambientais e biológicos. Alterações no ambiente ocasionados por ações antrópicas podem causar modificações nesse conforto e assim afetar a população. O objetivo deste trabalho foi identificar a ocorrência ou não de tendências no comportamento do conforto térmico em Manaus. Foram utilizados dados mensais de temperatura e umidade relativa do ar coletados pela estação Nº 82331 situada na área urbana do município, pertencente ao Instituto Nacional de Meteorologia (INMET) para o período de janeiro de 1986 a dezembro de 2017. Empregou-se o Índice de Calor, identificador biometeorológico que se baseia no balanço de energia para quantifica o conforto térmico; utilizou o teste de Mann-Kendall (MK) para detectar tendências e os métodos de Pettitt e Estimador de Tendência de Sen, para identificar o ponto de mudança e magnitude de possíveis tendências, respectivamente. O MK identificou tendências positivas significativas em todos os meses, o teste de Pettitt afere que as mesmas ocorreram no início desse século, com intensidade variando de 0,08°C a 0,14°C enfatizando os meses de junho, agosto e outubro com as maiores magnitudes encontradas. Conclui-se que a metodologia empregada identificou alterações com significância estatística o que indica que o desconforto térmico em Manaus vem aumento, o que pode ocasionar sérios prejuízos para os habitantes.
CARACTERIZAÇÃO MORFOMÉTRICA E USO E OCUPAÇÃO DA TERRA DA MICROBACIA HIDROGRÁFICA DO RIO ÁGUA BRANCA DE ITABUNA-BA/ Morphometric characterization and use and occupation of the earth of the hydrographic microbasin of the Rio Água Branca of Itabuna-BA
Authors: Macedo Samuel de Amaral , Moreau Mauricio Santana , Spanghero Pedro Enrico Salamim Fonseca
Published: July 2019

Este artigo tem como objetivo a caracterização a morfometrica e mapeamento do uso e ocupação da terra da Microbacia Hidrográfica do rio Água Branca (MBHRAB). Para atender o objetivo, utilizou-se o Banco de Dados Geomorfométricos do Brasil disponibilizado pelo Instituto Nacional de Pesquisas Espaciais (INPE) e imagens Google Earth Pro de 2018 para alimentar o ArcGIS 10.2.2, gerar, organizar e atualizar a base cartográfica da área estudada. As características geométricas apontam que a MBHRAB não é susceptível a inundação em condições normais de chuvas e apresenta média densidade hidrográfica (Dh). O estudo do relevo demonstrou que mais de 65% da bacia não favorece o balanço de radiação solar e nem o escoamento superficial. O mapeamento do uso e cobertura da terra evidenciou que a maior área da bacia é formada pela classe mata/cacau. Foram mapeados 6 km de áreas prioritárias para reflorestamento. Uma delas vem sendo utilizada para plantio de mudas auxiliando o cumprimento das ações de revitalização da Bacia do Rio Água Branca.
NOTA: EQUIPE EDITORIAL - REVISTA GEONORTE, V.10, N.34, JAN-JUN, 2019
Authors: Silva Neto João Cândido André da
Published: July 2019

NOTA: EQUIPE EDITORIAL - REVISTA GEONORTE, V.10, N.34, JAN-JUN, 2019
NOTA EDITORIAL: REVISTA GEONORTE, V.10, N.34, JAN-JUN, 2019
Authors: Silva Neto João Cândido André da
Published: July 2019

É com grande satisfação que publicamos o novo número da REVISTA GEONORTE, V.10, N.34, JAN-JUN, 2019. O atual número da REVISTA GEONORTE apresenta dez artigos científicos que tangem o temário da Geografia e áreas afins, apresentando contribuições científicas de diversas regiões do Brasil:
A percepção da paisagem  é abordada pelos autores Luiz Paulo Martins e Souza, Elisângela Lopes da Silva e André Weissheimer de Borba, apresentam a contribuição TRADIÇÃO E TRANSFORMAÇÃO DO PAMPA SERRANO DAS GURITAS DO CAMAQUÃ (CENTRO-SUL DO RIO GRANDE DO SUL, BRASIL: UM ESTUDO DE PERCEPÇÃO DA PAISAGEM.
No que tange a temática da Geografia Econômica a edição apresenta a DISTRIBUIÇÃO DE SHOPPING CENTERS NO ESTADO FLUMINENSE: OS SHOPPING CENTERS DO LESTE METROPOLITANO do autor Allex Serra Da Silva Ornellas.
A Geografia Urbana é representada pelo manuscrito intitulado REDE URBANA: UM TEMA DE ESTUDO RECORRENTE NA GEOGRAFIA BRASILEIRA da autora Franciele Miranda Ferreira Dias.
Sobre o Ensino de Geografia a edição atual da Revista Geonorte apresenta o trabalho de Juliano Tasca Bissotto e Roger Francisco Ferreira de Campos, intitulado: ANÁLISE DA PERCEPÇÃO AMBIENTAL DOS ALUNOS DO 8° ANO DA ESCOLA DE EDUCAÇÃO BÁSICA NAYA SAMPAIO GONZAGA NO MUNICÍPIO DE CAÇADOR, SANTA CATARINA.
Abarcado nas áreas a fins da Geografia, nas vertentes da meteorologia e hidrologia são apresentados os manuscritos IDENTIFICAÇÃO DE TENDÊNCIAS NO CONFORTO TÉRMICO NA REGIÃO NORTE DO BRASIL: ESTUDO DE CASO EM MANAUS-AM dos autores Tiago Bentes Mandú e Ana Carla Dos Santos Gomes; e o manuscrito O PROJETO HIDROGEOS-NEGRO NO ARQUIPÉLAGO DE ANAVILHANAS, NOVO AIRÃO (AM) dos autores Rogério Ribeiro Marinho, Naziano Pantoja Filizola, Wagner Picanço Moreira e Tereza Cristina Souza de Oliveira.
Contemplando as novas ferramentas tecnológicas para representação espacial os autores Fernanda Lampert Batista e Antoninho João Pegoraro, contribuem com o manuscrito intitulado: UTILIZAÇÃO DE SISTEMAS DE AERONAVES REMOTAMENTE PILOTADAS NA AGRICULTURA DE PRECISÃO.
Por fim são apresentados as diferentes tipos da utilização de Sistemas de Informação Geográfica (SIG) para mapeamento das variáveis geomorfológicas em bacia hidrográficas, apresentadas nos manuscritos: IDENTIFICAÇÃO DAS UNIDADES GEOMORFOMÉTRICAS A PARTIR DA DECLIVIDADE E PLANO DE CURVATURA NA BACIA HIDROGRÁFICA DO RIO HENRIQUE, RIO GRANDE DO SUL, BRASIL, de autoria de André Ricardo Furlan e Romário Trentin; CARACTERIZAÇÃO MORFOMÉTRICA E USO E OCUPAÇÃO DA TERRA DA MICROBACIA HIDROGRÁFICA DO RIO ÁGUA BRANCA DE ITABUNA-BA, de autoria de Samuel de Amaral Macedo, Mauricio Santana Moreau e Pedro Enrico Salamim Fonseca Spanghero; GEOPROCESSAMENTO COMO FERRAMENTA DE CARACTERIZAÇÃO MORFOMÉTRICA DA BACIA HIDROGRÁFICA DO RIO PARAUAPEBAS, PA, dos autores José Danilo Santana Pereira, Hilton Pereira Oliveira, Emanoelen Bitencourt e Bitencourt e Glauber Epifânio Loureiro.
 Boa leitura.
“It would be easier, you can do it anywhere, anytime”. Is the Philippines ready for HIV self-testing?
Authors: Gohil Jesal , Baja Emmanuel , SY Tyrone Reden , Guevara Ernest , Hemingway Charlotte , Medina Paul Mark , Coppens Leila , Dalmacion Godofreda V. , Taegtmeyer Miriam
Published: July 2019

Background: The Philippines is facing a rapidly rising HIV epidemic among young men who have sex with men (MSM). Testing rates among young populations is poor. HIV self-testing (HIVST) is a promising strategy to address this testing gap. Exploring the perceived acceptability, feasibility and programmatic challenges of HIVST among key informants and target users is an important first step.

Method: A qualitative study involving semi-structured interviews and focus group discussions (FGD). We interviewed 15 key informants involved with HIV testing programs or policies and 42 target users in six FGD in Metro Manila. We held separate discussions with high socio-economic MSM (n= 12), urban poor MSM (n=15) and transgender women (TGW) (n= 15). Results were analysed using a thematic framework approach.

Results: MSM and TGW welcomed the convenience and privacy HIVST could provide. They preferred an inexpensive accurate blood-based kit attained from reputable sites. Key informants at national and local level equally welcomed HIVST but identified a number of policy and regulatory issues. Both groups articulated the challenge of enrolling those who test reactive using HIVST to further testing and treatment in an environment characterised by acute stigma around HIV.

Conclusions: HIVST was found to be highly acceptable to target users and was welcomed as an additional testing approach at national level. Strategic alliances are now needed between stakeholders to proactively deliver a patient-centred HIVST program that could provide an effective, safe means of increasing testing coverage in this escalating context.
Total cholesterol affects the outcome in anterior cerebral artery-occluded acute ischemic stroke patients treated with thrombolysis
Authors: Niu Lei , Jiang Shaowei , Wang Yang , Peng Ya , Fei Aihua , Wang Hai-rong , Li Yi , Zhang Jingchen , Meaney Connor , Gao Chengjin , Pan Shuming
Published: July 2019

Object

In this study, we investigated whether certain types of lipid profiles are major contributors to disease outcomes.

Methods

At two stroke medical centers, among 13,285 hospitalized patients treated with thrombolysis, thrombectomy, or conventional care, two hundred and seventy-six anterior cerebral artery-occluded acute ischemic stroke (AIS) patients were screened. We examined the plasma lipid profiles by using the cutoff values from a receiver operating characteristic (ROC) curve. A multivariate logistic regression or Fisher’s exact test was used to compare the outcome and risk events. The modified Rankin scale (mRS) score was used to assess the major clinical outcome of the patients 3 months after disease onset. Mortality and symptomatic intracranial hemorrhage (sICH) were both evaluated as risk factors. The disease outcome was examined by analyzing symptom improvement at discharge.

Results

In the anterior cerebral artery-occluded AIS (NIHSS ≥ 10) patients treated by intravenous (IV) thrombolysis, a total cholesterol (TC) level greater than 5.07 mmol/L predicted a poor outcome (OR 3.55, 95% CI 1.21,10.46, p = 0.021).

Conclusion

In anterior cerebral artery-occluded AIS patients, the TC level is a highly promising screening factor for predicting the outcome of IV thrombolysis.
Canadian in-hospital mortality for patients with emergency-sensitive conditions: a retrospective cohort study
Authors: Berthelot Simon , Lang Eddy S. , Quan Hude , Stelfox Henry T.
Published: July 2019

BACKGROUND:
The emergency department sensitive hospital standardized mortality ratio (ED-HSMR) measures risk-adjusted mortality for patients admitted to hospital with conditions for which ED care may improve health outcomes. This study aimed to describe in-hospital mortality across Canadian provinces using the ED-HSMR.
METHODS:
Hospital discharge data were analyzed from April 2009 to March 2012. The ED-HSMR was calculated as the ratio of observed deaths among patients with emergency-sensitive conditions in a hospital during a year (2010-11 or 2011-12) to the expected deaths for the same patients during the reference year (2009-10), multiplied by 100. The expected deaths were estimated using predictive models fitted from the reference year. Aggregated provincial ED-HSMR values were calculated. A HSMR value above or below 100 respectively means that more or fewer deaths than expected occurred within a province.
RESULTS:
During the study period, 1,335,379 patients were admitted to hospital in Canada with an emergency-sensitive condition as the most responsible diagnosis. More in-hospital deaths (95% confidence interval) than expected were respectively observed for the years 2010-11 and 2011-12 in Newfoundland [124.3 (116.3-132.6); & 117.6 (110.1-125.5)] and Nova Scotia [116.4 (110.7-122.5) & 108.7 (103.0-114.5)], while mortality was as expected in Prince Edward Island [99.9 (86.5-114.8) & 100.7 (87.5-115.3)] and Manitoba [99.2 (94.5-104.1) & 98.3 (93.5-103.3)], and less than expected in all other provinces and territories.
CONCLUSIONS:
Our study revealed important variation in risk-adjusted mortality for patients admitted to hospital with emergency-sensitive conditions among Canadian provinces. The results should trigger in-depth evaluations to identify the causes for regional variations.
Dynamics of toxigenic Clostridium perfringens colonisation in a cohort of prematurely born neonatal infants
Authors: Shaw Alexander G , Cornwell Emma , Sim Kathleen , Thrower Hannah , Scott Hannah , Brown Joseph C S , Dixon Ronald A , Kroll J Simon
Published: July 2019

Background
Clostridium perfringens forms part of the human gut microbiota and has been associated with life-threatening necrotising enterocolitis (NEC) in premature infants. Whether specific toxigenic strains are responsible is unknown, as is the extent of diversity of strains in healthy premature babies. We investigated the C. perfringens carrier status of premature infants in the neonatal intensive care unit, factors influence this status, and the toxic potential of the strains.
Methods
C. perfringens was isolated by culture from faecal samples from 333 infants and their toxin gene profiles analysed by PCR. A survival analysis was used to identify factors affecting probability of carriage. Competitive growth experiments were used to explore the results of the survival analysis.
Results
29.4% of infants were colonized with C. perfringens before they left hospital. Three factors were inversely associated with probability of carriage: increased duration of maternal milk feeds, CPAP oxygen treatment and antibiotic treatment. C. perfringens grew poorly in breast milk and was significantly outperformed by Bifidobacterium infantis, when grown together or separately. Toxin gene screening revealed that infants carried isolates positive for collagenase, perfringolysin O, beta 2, beta, becA/B, netB and enterotoxin toxin genes, yet none were observed to be associated with the development of NEC.
Conclusions
Approximately a third of preterm infants are colonised three weeks after birth with toxin gene-carrying C. perfringens. We speculate that increased maternal breast milk, oxygen and antibiotic treatment creates an environment in the gut hostile to growth of C. perfringens. Whilst potentially toxigenic C. perfringens isolates were frequent, no toxin type was associated with NEC.
Trial Registration: clinicaltrials.gov NCT01102738, registered 13th April 2010
Establishing a Normative Database for Quantitative Pupillometry in the Pediatric Population
Authors: Shah Sanket S , Ranaivo Hantamalala Ralay , Mets-Halgrimson Rebecca B , Kurup Sudhi P
Published: July 2019

Purpose

Pupillary evaluation is a crucial element of physical exams. Noting size, reactivity, and consensual response is critical in assessing for optic nerve dysfunction. We aim to establish normative data for scotopic pupillary size and function in the pediatric population.

Methods

Pupillometry was obtained prospectively for consecutive, normal patients <18 years old being evaluated by Lurie Children’s Ophthalmology. Quantitative data included maximum (MAX) and minimum (MIN) diameters, constriction percentage (CON), latency (LAT), average (ACV) and maximum (MCV) constriction velocities, average dilation velocity (ADV), and 75% recovery time (T75). Iris color was noted as light, intermediate, or dark.

Results

196 eyes of 101 participants (42.6% male, ages 1–17 years, average age 10.3 years) were analyzed. Mean MAX was 6.6 mm (5.1–8.1 mm 95% CI); MIN was 4.7 mm (3.1–6.1 mm 95% CI); CON was 30% (17–42% 95% CI); LAT was 230 milliseconds (160–300 ms 95% CI); ACV was 3.70 mm/sec (2.21–5.18 mm/sec 95% CI); and ADV was 0.88 mm/sec (0.38–1.38 mm/sec 95% CI). Age had a positive correlation with MAX, MIN, and CON. 84.2% and 95.8% of participants showed resting pupil asymmetry of ≤0.5 mm and ≤1.0 mm, respectively.

Conclusions

Quantitative pupillometry can be a useful tool for screening pediatric patients. We sought to establish normative data in this group. We found males to have significantly greater MCV and CON than females (p < 0.05). Also, age had a positive correlation with MAX, MIN, and CON.

Keywords: Pupillometry; pupils; pediatric screening; normative
Titles: Facilitators and Barriers of Active Participation of caregivers of Children with Cerebral Palsy in their Rehabilitation: An Exploratory Study
Authors: Abdullahi Auwal , Isah Auwal
Published: July 2019

Background

Cerebral Palsy (CP) is a group of permanent disorders of movement and posture, attributed to non-progressive disturbance that occurred in the developing fetal or infant brain. The condition results in long term disability in carrying out activities of daily living (ADL). Thus, it most times required active participation of the caregivers of the children affected in their rehabilitation. The aim of the study is to explore the facilitators and barriers of active participation of caregivers in the rehabilitation of these children.

Materials and Methods

The study design used was qualitative interview. The participants consisted of caregivers of children with CP attending Hasiya Bayero Paediatric Specialists Hospital, Kano. The caregivers were sampled and interviewed by one of the researchers until theoretical saturation was attained. A note taker wrote down and recorded responses of the participants using a tape recorder. The data generated from the interview was then transcribed, coded and analyzed using matrix analysis using constant comparative analysis.

Results

Forty caregivers with mean age, 27 years participated in the study. The results of the study showed that, the facilitators are improvement in the child’s condition, family support, improvement in the conditions of other children with CP, encouragement from the therapist managing the child, empathy, and cooperation of the child during home programs. The barriers are number of children the caregiver has, caregiver’s occupation and financial resources.

Conclusion

Therapists need to help reinforce these facilitators, and devise strategies to help caregivers overcome barriers during rehabilitation of children with CP.
Maternal and partner’s level of satisfaction of the delivery room service in University of Gondar Referral Hospital, Northwest, Ethiopia: A comparative cross-sectional study
Authors: Taddese Asefa Adimasu , Gashaye Kiros Terefe , Dagne Henok , Andualem Zewudu
Published: July 2019

Background

Asking patients/clients what they perceive about the care and treatment they have received is an important step towards improving the quality of care, and ensure local health services are meeting patients’ needs. In the past globally, maternal satisfaction during the birthing process has been well documented, whereas little is known about the partners’ birth experiences. This study was conducted to evaluate and compare the birth satisfaction of mothers and partners who took intrapartum care in the study area.

Methods

Comparative cross-sectional study design was conducted from Dec 2018 to January 2019 in Gondar university referral hospital. The birth satisfaction scale is used for the mother, and it was adapted to the parents’ perspective. Paired-samples t tests were used for comparing mothers and partners for the birth satisfaction scales global and thematic scores. A binary logistic regression model was used to identify predicting factors for mothers’ and partners satisfaction.

Results

The overall satisfactions of mothers in this study were 47.6% whereas 41.2% of partners were satisfied by delivery room services. There were mean difference between mothers and partners’ birth satisfaction scale (p=0.020). Maternal satisfaction scale was affected by age [OR = 0.36, 95%CI (0.18, 0.73)], perception [OR =0.02, 95%CI (0.003,0.09)], waiting time [OR = 0.111, 95%CI (0.003, 0.091)],visiting mode [OR = 0.012, 95%CI (0.001,0.083)], pregnancy status [OR = 0.04, 95%CI (0.01, 0.33)], fatal outcome [OR=0.001, 95%CI (0.000,0.008)] .whereas, partners satisfaction was associated with age [OR=0.16,95%CI (0.05 0.49)], occupational status [OR = 0.02, 95%CI (0.00, 0.24), amount of money to pay for service [OR = 2.87, 95%CI (1.07, 7.71), visiting mode of his wife/client [OR = 0.08, 95%CI (0.019, 0.354)], waiting time [OR = 0.12, 95%CI (0.04, 0.33)], privacy [OR = 10.611, 95%CI (3.001, 37.52)], mode of delivery of his wife/client [OR = 7.69, 95%CI (3.00, 19.69)].

Conclusion

This finding would alert the health care system to design a client-friendly approach and provide insights to hospital administrators in formulating a policy that would enhance the support of first-time father give to their partner/wife during labor and delivery.
Ekonominių ciklų ypatumai ir analizė Lietuvoje
Authors: Barkauskaitė Aida , Eglinskaitė Vaida
Published: July 2019

Nuolatiniai svyravimai ir įvairūs ekonomikos pokyčiai lemia ekonominio augimo nepastovumą ir ekonominių ciklų susidarymą šalyse. Ekonominius ciklus ir jų ypatumus savo darbuose nagrinėjo daugybė mokslininkų: D. Štreimikienė ir J. Ramanauskienė (2012), R. Berthoud ir L. C. Sosa (2011), B. Rosier (2003), S. F. Fanning (2007), M. Bormotov (2009), J. Mackevičius (2012) ir daugelis kitų, tačiau mokslinės literatūros, kurioje būtų nagrinėjami ekonominių ciklų ypatumai ir dabartinis Lietuvos ekonominis ciklas, yra reta. Straipsnio tikslas – išnagrinėti ekonominių ciklų ypatumus ir nustatyti visos Lietuvos ir statybų sektoriaus ekonominių ciklų kitimo priežastis 1999–2013 m. laikotarpiu.Tyrimas atskleidė, jog ekonominio ciklo sąvoka apima bendrą visų pagrindinių ekonomikos rodiklių dinamiką; ciklas gali būti apibrėžiamas kaip periodiški verslo aktyvumo lygio svyravimai. Ekonominis ciklas gali būt suskirstytas į keturias fazes: pakilimo, nuosmukio, krizės ir pagyvėjimo. Šie etapai yra susiję su gamybos svyravimais, nedarbo lygiu, kapitalo ir darbo jėgos išteklių naudojimo lygiu, bendrųjų sąnaudų svyravimu ir kitais aspektais. Ekonominiai ciklai gali būti klasifikuojami atsižvelgiant į terminą, sunkumo mastą – recesijos fazės trukmę, sugebėjimą juos valdyti ir reguliuoti ir kt. Siekiant iš anksto prognozuoti ekonominio ciklo pokyčius, naudojamos rodiklių sekos, stebimi įvairių šalies sektorių rodiklių pokyčiai, kuriuos vertinant daromos prielaidos apie laukiamus ekonomikos svyravimus.

Ekonominio ciklo Lietuvoje analizė parodė, kad nuo 1999 m. iki 2007 m. Lietuvos ekonomika buvo augimo fazės. Nuo 2007 m. iki 2010 m. BVP augimas, vidaus vartojimas mažėjo, didėjo nedarbas, šalis išgyveno sunkų laikotarpį. Nuo 2010 m. iki 2013 m. nustatytas Lietuvos ekonomikos augimo laikotarpis, kas rodo ir tikėtiną tolesnį ekonomikos augimą Lietuvoje. Stebint statybų sektoriaus ekonominį ciklą 1999–2013 m., nustatyta, kad per analizuojamą laikotarpį žemiausią lygį ir didžiausius sunkumus sektorius patyrė 2009 metais. Didėjantis pasitikėjimo statybų sektoriumi lygis rodo tikėtiną statybos sektoriaus ir visos ekonomikos augimą. Ekonominių ciklų pokyčių numatymas padeda geriau pasirengti ir sumažinti neigiamų pasekmių lygį, todėl ekonominių ciklų analizė turėtų būti atliekama nuolatos.
Measurement of dynamic characteristics of coal during heating to assess its fire hazard
Authors:   Irkutsk National Research Technical University, Smirnov Grigoriy I.
Published: July 2019

Coal is the most valuable natural resource; however, during its extraction, storage and processing or burning, there is a risk of spontaneous combustion. Constant monitoring of its condition is required to prevent emergencies; however, currently applied methods for assessing fire danger of coal are complex and time-consuming. The purpose of the article ia to test and modify the method based on the equipment recommended by [10] in order to reduce the duration of the research and simplify the method for estimating the spontaneous combustion of coal. The study was conducted by thermal testing of spontaneous combustion of coal. When assessing the ability to self-ignition of coal samples extracted in Irkutsk oblast, coal samples having the same temperature of self-ignition but different dynamic characteristics of heating were identified. According to the dynamic characteristics, it is possible to identify the tendency of coal to spontaneous self-ignition. The results obtained are a basis for the database and a rapid analysis method for the spontaneous combustion of coal. A database of the dynamic characteristics of various coals and a detailed algorithm for conducting tests based on a software and hardware complex will reduce the time for evaluating fire-hazardous properties of coal and other combustible materials.
Performance Analysis of Hybrid ALOHA/CDMA RFID Systems with Quasi-decorrelating Detector in Noisy Channels
Authors: Hoang Tuyen Trung , Dao Hieu Van , Phan Vu Xuan , Nguyen Chuyen Thanh
Published: July 2019

In this paper we investigate the performance of a hybrid Aloha/CDMA radio frequency identification (RFID) system with quasi-decorrelating detector (QDD). Motivated by the fact that the QDD outperforms the conventional decorrelating detector (DD) in noisy network scenarios, we study and propose using QDD as one of the most promising candidates for the structure of RFID readers. Performance analysis in terms of bit error rate and the RFID system efficiency is considered considering CDMA code collision and detection error. Computer simulations are also performed, and the obtained results of QDD-based structure are compared with those of DD-based one to confirm the correctness of the design suggestion in different practical applications of tag identification and missing-tag detection.
Spectroscopic Studies of Asparaginyl-tRNA Synthetase from Entamoeba histolytica
Authors: Biswas Priyanka , Sahu Dillip K. , Sahu Kalyanasis , Banerjee Rajat
Published: July 2019

Background:

Aminoacyl-tRNA synthetases play an important role in catalyzing the first
step in protein synthesis by attaching the appropriate amino acid to its cognate tRNA which then
transported to the growing polypeptide chain. Asparaginyl-tRNA Synthetase (AsnRS) from Brugia
malayi, Leishmania major, Thermus thermophilus, Trypanosoma brucei have been shown to play
an important role in survival and pathogenesis. Entamoeba histolytica (Ehis) is an anaerobic eukaryotic
pathogen that infects the large intestines of humans. It is a major cause of dysentery and has
the potential to cause life-threatening abscesses in the liver and other organs making it the second
leading cause of parasitic death after malaria. Ehis-AsnRS has not been studied in detail, except the
crystal structure determined at 3 Å resolution showing that it is primarily α-helical and dimeric. It is
a homodimer, with each 52 kDa monomer consisting of 451 amino acids. It has a relatively short
N-terminal as compared to its human and yeast counterparts.

Objective:

Our study focusses to understand certain structural characteristics of Ehis-AsnRS using
biophysical tools to decipher the thermodynamics of unfolding and its binding properties.

Methods:

Ehis-AsnRS was cloned and expressed in E. coli BL21DE3 cells. Protein purification
was performed using Ni-NTA affinity chromatography, following which the protein was used for
biophysical studies. Various techniques such as steady-state fluorescence, quenching, circular dichroism,
differential scanning fluorimetry, isothermal calorimetry and fluorescence lifetime studies
were employed for the conformational characterization of Ehis-AsnRS. Protein concentration for
far-UV and near-UV circular dichroism experiments was 8 µM and 20 µM respectively, while 4
µM protein was used for the rest of the experiments.

Results:

The present study revealed that Ehis-AsnRS undergoes unfolding when subjected to increasing
concentration of GdnHCl and the process is reversible. With increasing temperature, it
retains its structural compactness up to 45ºC before it unfolds. Steady-state fluorescence, circular
dichroism and hydrophobic dye binding experiments cumulatively suggest that Ehis-AsnRS undergoes
a two-state transition during unfolding. Shifting of the transition mid-point with increasing
protein concentration further illustrate that dissociation and unfolding processes are coupled indicating
the absence of any detectable folded monomer.

Conclusion:

This article indicates that GdnHCl induced denaturation of Ehis-AsnRS is a two –
state process and does not involve any intermediate; unfolding occurs directly from native dimer to
unfolded monomer. The solvent exposure of the tryptophan residues is biphasic, indicating selective
quenching. Ehis-AsnRS also exhibits a structural as well as functional stability over a wide
range of pH.
Characteristics and Function of the Chitin Binding Protein from Xenorhabdus nematophila
Authors: Liu Jia , Song Ping , Zhang Jie , Nangong Ziyan , Liu Xiaobei , Gao Yue , Wang Qinying
Published: July 2019

Background:

Genome sequence analysis (GenBank access No.: FN667742.1) shows that
Xenorhabdus nematophila ATCC19061 contains one gene (Xn-cbp) encoding chitin binding protein
(Xn-CBP).

Objective:

The present work aims to clarify the characteristics and function of Xn-CBP from
X. nematophila HB310.

Methods:

In this study, the Xn-cbp gene was cloned and expressed in Escherichia coli BL21 (DE3).
Substrate binding assays were performed to explain the ability of Xn-CBP combined with the polysaccharide.
The insecticidal toxicity of Xn-CBP against the second-instar larvae of Helicoverpa
armigera was determined by feeding method. Besides, the antifungal activity of Xn-CBP against
Coniothyrium diplodiella, Verticillium dahlia, and Fusarium oxysporum was tested by spore germination
assay and hyphal extension assay.

Results:

Xn-CBP encoded 199 amino acids with a calculated mass of 28 kDa, which contained a
signal peptide and a chitin binding domain. The Bmax and Kd values of Xn-CBP to colloidal chitin
were 2.46 and 4.08, respectively. Xn-CBP had insecticidal activity against the H. armigera with a
growth inhibition rate of 84.08%. Xn-CBP had the highest spore germination inhibitory effect on C.
diplodiella with the inhibition rate of 83.11%. The hyphal growth inhibition rate of Xn-CBP to F.
oxysporum, 41.52%, was higher than the other two fungi.

Conclusion:

The Xn-CBP had the highest binding ability to colloidal chitin and it showed insecticidal
activity and antifungal activity. The present study laid a foundation for further exploitation
and utilization of X. nematophila.
Natural Products Derived from the Mediterranean Diet with Antidiabetic Activity: from Insulin Mimetic Hypoglycemic to Nutriepigenetic Modulator Compounds
Authors: Deligiannidou Georgia-Eirini , Philippou Elena , Vidakovic Melita , Berghe Wim V. , Heraclides Alexandros , Grdovic Nevena , Mihailovic Mirjana , Kontogiorgis Christos
Published: July 2019

Background:

The Mediterranean diet is a healthy eating pattern that protects against the development
of Type 2 diabetes mellitus (T2DM), a metabolic disease characterized by elevated blood sugar levels due to
pancreatic beta-cell functional impairment and insulin resistance in various tissues. Inspired by the ancient communities,
this diet emphasizes eating primarily plant-based foods, including vegetables, legumes, fruits, cereals,
and nuts. Importantly, virgin olive oil is used as the principal source of fat. Red meat is consumed in low amounts
while wine and fish are consumed moderately.

Objective:

Here, we review the most beneficial components of the Mediterranean Diet and tentative mechanisms
of action for prevention and/or management of T2DM, based on research conducted within the last decade.

Methods:

The references over the last five years have been reviewed and they have been selected properly according
to inclusion/ exclusion criteria.

Results:

Several bioactive diet components were evaluated to prevent inflammation and cytokine-induced oxidative
damage, reduce glucose concentration, carbohydrate absorption and increase insulin sensitivity and related
gene expression.

Conclusion:

The adherence to a healthy lifestyle, including diet, exercise and habits remains the best approach
for the prevention of diabetes as well as frequent check-ups and education. Though diabetes has a strong genetic
component, in recent years many reports strongly point to the critical role of lifestyle specific epigenetic modifications
in the development of T2DM. It remains to be established how different components of the Mediterranean
Diet interact and influence the epigenetic landscape to prevent or treat the disease.
Profile of Fatty Acids, Tocopherols, Phytosterols and Polyphenols in Mediterranean Oils (Argan Oils, Olive Oils, Milk Thistle Seed Oils and Nigella Seed Oil) and Evaluation of their Antioxidant and Cytoprotective Activities
Authors: Zarrouk Amira , Martine Lucy , Grégoire Stéphane , Nury Thomas , Meddeb Wiem , Camus Emmanuelle , Badreddine Asmaa , Durand Philippe , Namsi Amira , Yammine Aline , Nasser Boubker , Mejri Mondher , Bretillon Lionel , Mackrill John J. , Cherkaoui-Malki Mustapha , Hammami Mohamed , Lizard Gérard
Published: July 2019

Background:

The effects of vegetable oils on human health depend on their components. Therefore,
their profiles of lipid nutrients and polyphenols were determined.

Objective:

To establish and compare the fatty acid, tocopherol, phytosterol and polyphenol profiles of Mediterranean
oils: cosmetic and dietary argan oils (AO; Morocco: Agadir, Berkane); olive oils (OO; Morocco, Spain,
Tunisia); milk thistle seed oils (MTSO; Tunisia: Bizerte, Sousse, Zaghouane); nigella seed oil (NSO).

Methods:

The biochemical profiles were determined by gas chromatography-flame ionization, high performance
liquid chromatography and gas chromatography, coupled with mass spectrometry as required. The antioxidant
and cytoprotective activities were evaluated with the KRL (Kit Radicaux Libres) and the fluorescein diacetate
tests on nerve cells treated with 7-ketocholesterol (7KC).

Results:

The fatty acid profile revealed high linoleic acid (C18:2 n-6) content in AO, OO, MTSO and NSO. The
highest levels of oleic acid (C18:1 n-9) were found in AO and OO. The tocopherol profile showed that Agadir
AO contained the highest amount of α-tocopherol, also present at high level in MTSO and Tunisian OO; Berkane
AO was rich in γ-tocopherol. The phytosterol profile indicated that β-sitosterol was predominant in the oils, except
AO; spinasterol was only present in AO. Polyphenol profiles underlined that OO was the richest in polyphenols;
hydroxytyrosol was only found in OO; few polyphenols were detected in AO. The oils studied have antioxidant
activities, and all of them, except NSO, prevented 7KC-induced cell death. The antioxidant characteristics of
AO were positively correlated with procatechic acid and compestanol levels.

Conclusion:

Based on their biochemical profiles, antioxidant and cytoprotective characteristics, AO, OO, and
MTSO are potentially beneficial to human health.
Nanoemulsions Loaded with Amphotericin B: Development, Characterization and Leishmanicidal Activity
Authors: Araújo Gabriela Muniz Félix , Araújo Gabriela Muniz Félix , Barros Alana Rafaela Albuquerque , Barros Alana Rafaela Albuquerque , Oshiro-Junior João Augusto , Oshiro-Junior João Augusto , Soares Leonardo Ferreira , Soares Leonardo Ferreira , da Rocha Louisianny Guerra , da Rocha Louisianny Guerra , de Lima Ádley Antonini Neves , de Lima Ádley Antonini Neves , da Silva José Alexsandro , da Silva José Alexsandro , Converti Attilio , Converti Attilio , Damasceno Bolívar Ponciano Goulart de Lima , Damasceno Bolívar Ponciano Goulart de Lima
Published: July 2019

Leishmaniasis is one of the most neglected diseases in the world. Its most severe clinical form, called
visceral, if left untreated, can be fatal. Conventional therapy is based on the use of pentavalent antimonials and
includes amphotericin B (AmB) as a second-choice drug. The micellar formulation of AmB, although effective, is
associated with acute and chronic toxicity. Commercially-available lipid formulations emerged to overcome such
drawbacks, but their high cost limits their widespread use. Drug delivery systems such as nanoemulsions (NE)
have proven ability to solubilize hydrophobic compounds, improve absorption and bioavailability, increase efficacy
and reduce toxicity of encapsulated drugs. NE become even more attractive because they are inexpensive
and easy to prepare. The aim of this work was to incorporate AmB in NE prepared by sonicating a mixture of
surfactants, Kolliphor® HS15 (KHS15) and Brij® 52, and an oil, isopropyl myristate. NE exhibited neutral pH,
conductivity values consistent with oil in water systems, spherical structures with negative Zeta potential value,
monomodal size distribution and average diameter of drug-containing droplets ranging from 33 to 132 nm. AmB
did not modify the thermal behavior of the system, likely due to its dispersion in the internal phase. Statistically
similar antileishmanial activity of AmB-loaded NE to that of AmB micellar formulation suggests further exploring
them in terms of toxicity and effectiveness against amastigotes, with the aim of offering an alternative to treat
visceral leishmaniasis.
Evaluasi Pembelajaran Mata Kuliah Menejemen Usaha Busana Modiste
Authors: Sintawati Esin , Nurdiansyah Rudi , Purwaningsih Nur Endah
Published: July 2019

Menejemen Usaha Busana (MUB) Modiste merupakan mata kuliah yang diselenggarakan Program Studi Tata Busana D3 maupun S1.Tujuan penelitian  untuk   (1) mengetahui pelaksanaan model pembelajaran pada MUB Modiste berkaitan dengan komponen konteks, (2) mengetahui  efektivitas  model pembelajaran Teaching Factory- enam Model pada tahap input yang berhubungan dengan teknis pengelolaan, administrasi, alokasi waktu serta sarana dan prasarana. Penelitian ini merupakan penelitian evaluasi yang bertujuan untuk mengetahui tingkatketerlaksanaan suatu kebijakan secaracermat dengan cara mengetahui efektivitasmasing-masing komponen yang dievaluasidengan pendekatan model CIPP (Context, Input, Process, Product). Hasil penelitian menunjukkan bahwa (1) pembelajaran MUB Modiste terlaksana karena telah memiliki landasan yuridis berupa kurikulum, sesuai dengan visi misi program studi, (2) pembelajaran MUB Modiste didukung oleh aspek teknis pelaksanaan yang rinci dan konsisten, alokasi waktu pelaksanaan yang memadai untuk pelaksanaan pembelajaran usaha, administrasi yang standar sesuai yang berlaku serta sarana prasarana yang memadai, (3) aspek proses pelaksanaan pembelajaran MUB Modiste telah didukung oleh kompetensi dosen yang sesuai dan memadai, serta dalam prosesnya memiliki model yang sesuai dengan standar dan tujuan pembelajaran.
Penerapan Kesehatan dan Keselamatan Kerja (K3) pada Laboratorium Tata Rias dan Kecantikan
Authors: Tritanti Asi , Siregar Ika Pranita
Published: July 2019

Penelitian bertujuan: (1) mengetahui penerapan K3 di prodi tata rias untuk  diri sendiri, alat dan bahan praktik, serta area kerja, (2) membuat Standar Operasional Prosedur (SOP) yang sesuai K3 untuk kegiatan praktik (2) tata kecantikan kulit, (3) tata kecantikan rambut, dan (4) tata rias pengantin. Penelitian ini adalah penelitian deskriptif kualitatif model interaktif Miles dan Huberman. Subjek penelitian adalah mahasiswa prodi tata rias  semester genap 2015/2016 dan semester ganjil 2016/2017, dosen dan laboran Prodi Tata Rias. Data dikumpulkan dengan lembar observasi, kuisioner dan wawancara. Teknik analisis data yang digunakan adalah deskriptif  kualitatif. . Hasil penelitian menunjukkan: (1) Kesehatan dan Keselamatan Kerja (K3) di prodi tata rias pada diri sendiri, alat dan bahan praktik, serta area kerja praktik sudah diterapkan. Mahasiswa, laboran dan dosen pengampu memiliki komitmen melakukan K3, memiliki pengetahuan dasar K3, dan bersedia menerapkan K3 sesuai dengan SOP yang berlaku, Standar Operasional Prosedur yang sesuai prinsip K3 untuk (2) bidang keahlian tata kecantikan kulit dibuat dengan memperhatikan prinsip dasar dan kompetensi tata kecantikan kulit, (3) tata kecantikan rambut dibuat dengan memperhatikan prinsip dasar dan kompetensi tata kecantikan rambut, dan (4) praktik tata rias pengantin dibuat dengan memperhatikan konsep dasar dan jenis tata rias pengantin dengan kompetensi rias pengantin Indonesia, pengantin Barat, dan Pengantin Muslim
Pembuatan Tempe Bekatul Dan Kandungan Gizinya
Authors: Auliana Rizqie
Published: July 2019

Penelitian bertujuan: 1) mengetahui formula tempe bekatul yang tepat sesuai dengan karakteristik bekatul, 2) mengetahui daya terima konsumen terhadap tempe bekatul, dan 3) mengetahui kandungan gizi tempe bekatul berdasarkan analisis proksimat. Jenis penelitian adalah eksperimen di Laboratorium Program Studi Pendidikan Teknik Boga, Universitas Negeri Yogyakarta dan Chemix Pratama. Disain penelitian adalah rancangan blok lengkap 3 kali ulangan percobaan dan 2 kali sampel. Formula tempe bekatul 1 dan 2 menggunakan 7½ % , 10%, dan 12½ %. Hasil penelitian: 1) Formula tempe bekatul yang tepat baik tempe bekatul 1 maupun 2 adalah 10% bekatul, 90%  kedelai dan 8% ragi tempe. 2) Tempe bekatul  yang disukai adalah formula 2 dengan substitusi 10%. 3) Kandungan gizi tempe bekatul 1 dan 2 tidak berbeda jauh dengan tempe kedelai. Kadar air tempe bekatul 60-61%. Kadar abu  tertinggi adalah tempe bekatul 2 sebesar 1,5452%.  Kandungan protein tempe kedelai adalah 17,7712%, tempe bekatul 1 adalah 16,1638%, dan tempe bekatul 2 adalah 17,8622%. Kandungan lemak tertinggi dimiliki tempe bekatul 1 sebesar 10,3032% . Serat kasar tempe bekatul 2 lebih rendah 5,4824% dibandingkan tempe bekatul 1. Kandungan karbohidrat dan energi lebih tinggi pada tempe bekatul 1 sebesar 4,7637%
Peningkatan Self-Directed Learning Readiness Mahasiswa Dalam Mata Kuliah Fotografi Dasar Melalui Flipped Classroom Dan Ict
Authors: Satrio Putra Uji Deva , Utami Athika Dwi Wiji
Published: July 2019

Penelitian ini menggunakan pendekatan kualitatif dengan metode Lesson Study berbasis Classroom Action Research. Kegiatan Lesson Study mencakup 3 tahap kegiatan dalam satu siklus yaitu Plan, Do, dan See selama 3 siklus yang melibatkan dua dosen observer. Hasil Lesson Study menunjukkan bahwa pelaksanaan Lesson Study selama 3 siklus ini, antara lain : (1) Suasana perkuliahan menjadi “lebih hidup” ditunjukkan oleh meningkatnya keaktifan belajar mahasiswa selama 3 siklus tersebut; (2) Penerapan Flipped classroom meningkatkan kesiapan mahasiswa dalam mengikuti perkuliahan, yang dapat dilihat dari adanya peningkatan keaktifan dan kesiapan mahasiswa pada setiap siklusnya saat berada pada sesi tanya jawab dan diskusi kelompok; (3) Terjadi perubahan pola pembelajaran dosen berupa semakin mengurangi penggunaan ceramah dan menambah variasi metode serta penggunaan media; (4) Semua dosen yang terlibat baik dosen model maupun dosen observer ada kecenderungan semakin bisa bekerja sama dengan teman sejawat ,semakin terbuka dalam mengemukakan kekurangan, dan semakin berkeinginan untuk selalu meningkatkan kualitas pembelajarannya; dan (5) Tanggapan mahasiswa terhadap penerapan flipped classroom berbantu ICT terhadap kemandirian mahasiswa pada perkuliahan Fotografi Dasar adalah positif.
Rancangan Pembelajaran Teaching Factory Di Smk Tata Busana
Authors: Fitrihana Noor
Published: July 2019

Peraturan Pemerintah Republik Indonesia Nomor 41 Tahun 2015  tentang pembangunan sumber daya industri menyatakan bahwa  penyelenggaraan pendidikan vokasi industri berbasis kompetensi harus dilengkapi dengan Lembaga Sertifikasi Profesi (LSP), pabrik dalam sekolah (teaching factory), dan tempat uji kompetensi (TUK). Peraturan Menteri Pendidikan dan Kebudayaan Nomor 22 tahun 2016 tentang standar proses pendidikan dasar dan menengah menyatakan bahwa salah satu model pembelajaran yang perlu dikembangkan adalah  pembelajaran yang menghasilkan karya berbasis pemecahan masalah (project based learning) disesuaikan dengan karakteristik kompetensi dan jenjang pendidikan.  Kedua peraturan ini menjadi landasan implementasi teaching factory (TEFA) di sekolah menengah kejuruan (SMK). Makalah ini selanjutnya akan membahas tentang rancangan pembelajaran  TEFA di SMK kompetensi keahlian Tata Busana
Breaking Paradigms: Towards a Multi-, Inter- and Transdisciplinary Science” In commemoration of the 250th Anniversary of Alexander von Humboldt
Authors: Morera Cordova Vivian
Published: July 2019

To celebrate the 250th anniversary of Alexander von Humboldt, from February 22th to February 24th occurred in the city of Ibarra, Ecuador the Humboldt kolleg “Breaking Paradigms: Towards a Multi-, Inter- and Transdisciplinary Science”. The event was held at the facilities of the Hotel Ajaví. This Humboldt kolleg aimed to create a space for Humboldtians, young doctors in science and young researchers of Latin America for disseminating their results, as well as to create collaborative and cooperative relationships and strengthen the existing one, in order to take steps forward in scientific knowledge within Latin America. The event also had the purpose of creating the space for the dissemination of the programs offered by the Alexander von Humboldt Foundation to young doctors in science for conducting their research in leading laboratories in Germany.
Effect of six bis-THTT derivatives in the control of parasitaemia in two rodent malaria species
Authors: Loachamin Katherine S. , Rodríguez Hortensia M.
Published: July 2019

Malaria is a life-threatening disease caused by parasites of the genus Plasmodium and is transmitted to humans by the bite of female mosquitoes of the genus Anopheles. WHO has reported 219 million cases of malaria and 435,000 deaths were estimated in 2017. The anti-malarial treatment more frequently used is based on Chloroquine, which has been used for several decades. This prolonged application has caused the parasite to develop resistance to the use of the mentioned drug, so it becomes necessary to search for new treatments. In addition, some tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (THTT) derivatives have been previously studied as possible trypanosomicides, obtaining satisfactory results in the treatment to Trypanosoma cruzi; Trichomonas vaginalis and T. b. rhodesiense, although no studies against malaria have been reported. In the present work, six bis-THTT derivatives were evaluated as potential anti-malarial drugs (JH1, JH2, JH3, JH4, JH5, and JH6) with BALB/c mice, which were inoculated with Plasmodium berghei ANKA strain and Plasmodium yoelii 17XL strain. The percentages of parasitemia were determined for each tested compound, which was assessed daily on smears from tail blood, stained with Giemsa’s reagent and observed under light microscopy as evidence of cure. Our results showed that JH2 and JH4 presented effective parasitemia control similar to chloroquine in P. berghei. Besides, JH5 and JH6 exhibited better results than Chloroquine with P. yoelii infection. In summary, four of the six bis-THTT derivatives tested, could be considerate as potential new drugs to infection malaria rodent control. Immune response essays should be realized in order to confirm our preliminary results.
General Approach to Drug Delivery Systems (DDS)
Authors: Belén Castillo Danna , Rodriguez Hortensia M.
Published: July 2019

The field of drug discovery drives to find out efficient, selective, stable and biocompatible new drugs. The purpose of drug delivery systems (DDS) is to reduce the side effects that treatments usually cause to mitigate some diseases, especially cancer. Cancer treatments are usually so strong and invasive that they end up weakening the patient, so the cure became as dangerous as the disease. That is the reason that DDS try to maximize the effectiveness of the drugs administered by wanting them to reach specifically to the area affected by the disease (High specificity). In this regard, the fruitfully use of liposome-, erythrocytes-, nanoparticles- or antibodies-based therapies became a choice for the treatment of a huge range of diseases, due to the biocompatibility that these macromolecular systems present. In the last five years, a broad range of DDS have been developed, and some of them, specifically four ADC´s are approved by the FDA and commercializing. In this work, we summarized the most important approach to DDS obtained through chemical conjugation, highlighting ADC´s like the most promising controlled release systems.