bluuebunny/crossref_metadata_2025 huggingface dataset:
La prospectiva de los clubes universitarios de ciencia, como estrategia de Responsabilidad Social Universitaria en Tabasco
Authors: Arias Herrera Josúe , Medina Morales Gladys del Carmen
Published: January 2022

Los Clubes Universitarios de Ciencia (CUC) son un conjunto multidisplinario de estudiantes integradospara impartir talleres de ciencia experimentales o demostrativos con el objetivo de acercar al quehacercientífico a jóvenes y niños y fomentar su interés por la ciencia. Una estrategia de responsabilidad social,que realiza la Universidad Juárez Autónoma de Tabasco (UJAT) a través de los CUC a partir del 2014.La estrategia consistió en impartición de talleres de divulgación científica a estudiantes de educaciónmedia superior del estado de Tabasco. Se presentan datos descriptivos de un caso de estudio sobre sulabor de divulgación científica con el propósito de describir la prospectiva de los clubes de ciencia comoestrategia de responsabilidad social de la UJAT. El estudio tuvo el objetivo de describir las actividades dela conformación y de desarrollo de los CUC, comprende un periodo de cuatro años en el que se impartieron140 talleres, en 30 planteles de tres diferentes subsistemas de los 17 municipios del Estado, a 3,400estudiantes con una participación activa de 344 estudiantes como talleristas (M:210, H:134). Con ellola UJAT sensibiliza a un sector importante de la sociedad a interesarse por la actividad científica, enuna etapa crucial para decidir su futuro profesional. Este impulso a las vocaciones científicas es un actoprimordial de Responsabilidad Social frente a los retos que encara el país.Palabras clave: Responsabilidad Social; Divulgación Científica; Formación de científicos; Clubes de Ciencia
Ética, Desarrollo Sostenible y Responsabilidad Social desde la docencia en instituciones de educación superior latinoamericanas
Authors: García Rangel Fabiola , Vega Cano Rosa , Vallaeys François
Published: January 2022

El presente documento muestra los resultados de un análisis de las reflexiones vertidas por docentes y funcionarios universitarios de ocho países de América Latina, quienes participaron en las dos ediciones de un diplomado internacional, producto de la colaboración entre la Unión de Responsabilidad Social Universitaria Latinoamericana (URSULA) y la Universidad Michoacana de San Nicolás de Hidalgo, cuyo eje de trabajo fue el análisis del impacto que tiene la labor docente sobre el desarrollo sostenible.
El estudio se desarrolló desde un enfoque mixto. Mediante un análisis de contenido se analizaron cualitativamente 410 contribuciones realizadas por quienes participaron en el diplomado y, posteriormente, se llevó a cabo un análisis de frecuencias para cuantificarlas en torno a los ámbitos y metas del Modelo de Responsabilidad Social Universitaria propuesto por URSULA.
El trabajo concluye señalando que la docencia universitaria debe ser revalorada, en términos de su contribución al desarrollo sostenible, pues a través de su ejercicio se materializa la pertinencia social de la formación profesional mediante el desarrollo de prácticas y contenidos que acerquen al estudiantado a la realidad económica, social y ambiental en que viven.
Palabras clave: Ethics, Sustainable Development and Social Responsability from university teaching in Latin American higher education institutions
La Responsabilidad Social Universitaria y su implementación: una revisión panorámica
Authors: Palacios Rodríguez Oscar Alejandro , Olvera León Guadalupe del Carmen , Sánchez-Armáss Cappello Omar , Medina Orta Sayra Yesenia , Armendáriz Zarazua Roxana Elizabeth
Published: January 2022

El presente tuvo como objetivo explorar las investigaciones empíricas recientes sobre la Responsabilidad Social Universitaria (RSU). Se realizó una revisión de literatura basada en el diseño de scoping review de Arksey y O´Malley. Los resultados muestran que la mayoría de los estudios han sido publicados en Latinoamérica, en español y abordan temas principalmente relacionados al concepto, la enseñanza y los problemas de la RSU. La literatura muestra que el concepto de RSU ha incorporado diversas dimensiones que integran, particularmente, el cuidado del medio ambiente. Si bien la mayoría de los estudios se realizaron desde una aproximación cualitativa, las alternativas metodológicas utilizadas han sido diversas, de manera que no hay consenso sobre aquella que se defina como la más pertinente. La evaluación de la RSU al interior de las universidades, debe tener como base datos empíricos que permitan tomar decisiones respecto a sus funciones principales: la docencia, la investigación y la extensión; pues las problemáticas sociales actuales demandan soluciones que tengan como base los principios de la RSU en el trabajo conjunto de las universidades con la comunidad y otros sectores.
Palabras clave: responsabilidad social; universidad; literatura; revisión
Atitudes de enfermeiros de um hospital de ensino no cuidado de fam��lias
Authors: Schultz Vania Greice da Paz , Schwartz Eda , Spagnolo L��lian Moura de Lima , Sampaio AurǸlia Danda , Lise Fernanda
Published: January 2022

Objetivo: Descrever as atitudes de enfermeiros perante o cuidado de fam��lias, utilizando a Escala Importǽncia das Fam��lias nos Cuidados de Enfermagem �_" Atitudes dos Enfermeiros. MǸtodo: Estudo quantitativo, descritivo de recorte transversal, realizado com 126 enfermeiros em um Hospital Escola. Utilizou-se um formulǭrio estruturado para se obter a caracteriza��ǜo dos participantes e a escala Importǽncia das Fam��lias nos Cuidados de Enfermagem �_" Atitudes dos Enfermeiros, para analisar a atitude de apoio dos enfermeiros em rela��ǜo ��s fam��lias. Aplicou-se anǭlise estat��stica descritiva estratificando os escores obtidos na escala e subescalas pelas caracter��sticas dos Enfermeiros. Resultados: O escore mǸdio total obtido, na escala, foi de 84,4 (DP=8,6), demonstrando uma atitude de apoio ��s fam��lias. Entretanto, ao estratificar-se pelas caracter��sticas dos Enfermeiros, observou-se escores de baixo apoio dentre aqueles que nǜo tiveram experiǦncia prǸvia de ter um familiar gravemente enfermo e dos que nǜo tiveram algum contato prǸvio com o conteǧdo de enfermagem da fam��lia. Conclus��es e implica����es para a prǭtica: os enfermeiros apresentaram atitudes de apoio perante ��s fam��lias. O que na prǭtica assistencial aproxima a fam��lia e a enfermagem, potencializando a troca de informa����es e a corresponsabiliza��ǜo da fam��lia pelo tratamento.
Prǭticas pedag��gicas adotadas por docentes na forma��ǜo de enfermeiros-l��deres
Authors: Varanda Patr��cia Alves Galhardo , Amestoy Simone Coelho , Silva Gilberto Tadeu Reis da , Backes Vǽnia Marli Schubert , Trindade Let��cia De Lima , Bǭo Ana Cristina Pretto
Published: January 2022

Objetivo: Conhecer as prǭticas pedag��gicas adotadas por docentes de enfermagem, para a forma��ǜo de enfermeiros-l��deres. MǸtodo: Estudo de caso, de abordagem qualitativa, realizado com 36 docentes de enfermagem de uma universidade pǧblica no estado da Bahia. Foram realizadas entrevistas semiestruturadas e os dados tratados conforme o referencial te��rico de Paulo Freire, com aux��lio da Anǭlise Temǭtica e do software Nvivo��11. Resultados: Os docentes reconhecem o ensino da lideran��a inserido nas discuss��es te��rico-prǭticas, buscam atuar como facilitadores no ensino da lideran��a e valorizam a inser��ǜo desta, na matriz curricular, bem como o est��mulo �� autonomia e cr��tica reflexiva dos discentes. Conclusǜo: Faz-se importante a inser��ǜo do ensino da lideran��a na matriz curricular, conhecendo as prǭticas pedag��gicas adotadas pelos docentes, no sentido de fortalecer a autonomia e o racioc��nio cr��tico dos discentes, durante o processo de ensino e aprendizagem.
Investigation of the logistics chain of cargo delivery in the context of choosing a freight forwarding company
Authors:   Emperor Alexander I Petersburg State Transport University, NIKIFOROVA Guzel I.
Published: January 2022

Objective: The choice of a logistics and freight-forwarding company by the cargo owner at the initial stage of planning the logistics chain of cargo delivery. Methods: The analysis of the logistics chain of cargo delivery, methods of deploying quality functions when choosing a transport company and expert assessment are applied. Results: A system of traditional and logistic models of forwarding, a scheme for differentiating the requirements of a cargo owner is presented, a matrix for the deployment of quality functions is built, an example of expert assessment of the parameter of a transport and logistics company is developed. Practical importance: Using the quality function deployment method makes it possible to translate the cargo owner’s requests into specifi cations and requirements. The competitiveness of the given transport and logistics company is assessed.
The principles of the theory of fuzzy sets in the formalization of infrastructural and technological interaction of the port railway transport system
Authors:   Scientifi c and Technological University (NTU) “Sirius”, CHISLOV Oleg N. , BESUSOV Danil S. ,   Rostov State Transport University
Published: January 2022

Objective: Formulating proposals for improving the indicators of infrastructural and technological interaction when assessing multivariate management decisions in the regional railway system on the example of the “port station – port” system. Methods: Drawing on the analysis of publications in the given research area, a modifi cation of the methods of the theory of fuzzy sets and the theory of probability was applied to select and formalize the most important transport and technological processes of port stations, taking into account possible stochastic phenomena in the management of the interaction between the station and the port. Results: The theoretical substantiation of the degree of belonging of the axiom of station transport and technological processes to certain conditions of interaction between the station and the port, the relationship of their association and inclusion is obtained. A matrix of links between the main technological operations and infrastructural elements for a specifi c port station has been developed. An example is presented and the axioms of transport processes of options for servicing port berths are described. Approaches to the assessment of logical situations and fuzziness of subsets of parameters of transport processes in the control of the interaction between the station and the port are formulated. In the environment of the analytical computing system, the time parameters of the options for organizing transport processes are determined. Practical importance: The visualization of the fuzzy organization of transport sub-processes was performed, the degree of logical correspondence between the axiom of station transport and technological processes and their entropy were assessed, a diagram of the membership of a set of times of transport process variants was constructed, which allows taking into account poorly formalized processes in managing the operation of the “port station – port” system and, in the future, reduce local cars inactivity in the system.
Export of Services by Kazakhstan: Trends, Structure, Growth Potential
Authors: Dodonov V.
Published: January 2022

The article examines the situation with the export of services from Kazakhstan. The dynamics of the volume and relative parameters of export of services, its structure by main types and geographical areas are analyzed. Long-term tendencies of foreign trade in services are revealed, the role of export of services in the total volume of exports of Kazakhstan is compared with other countries and their groups. The features of the export of the two largest types of Kazakhstani export of services – transport and travel are considered in detail. The directions of stimulating export of certain types of services that can make a significant contribution to increasing exports and ensure the advanced development of non-resource foreign trade are substantiated.
Labor Migration in CIS and Russian Labor Market
Authors: Khokhlova M.
Published: January 2022

The technological revolution alongside with the coronavirus pandemic have changed the composition of immigrants to Russia from the CIS countries: there are more job applications coming from programmers and IT developers. The lack of such specialists in Russia forces employers to raise their salaries and offer better working conditions. Relationships between Russia and the CIS in the labor market (center–periphery) are often mutually beneficial to both parties. The article addresses the need of changing professional affiliations as well as retraining domestic specialists in order to reduce their deficit. The article presents the ILO data about insufficiently elaborated legal framework to counter informal employment for distant “immigrants”.
An Exploration of Pathologies of Multilevel Principal Components Analysis in Statistical Models of Shape
Authors: Farnell Damian JJ
Published: January 2022

3D facial surface imaging is a useful tool in dentistry and in terms of diagnostics and treatment planning. Between-groups PCA (bgPCA) is a method that has been used to analyse shapes in biological morphometrics, although various “pathologies” of bgPCA have recently been proposed. Monte Carlo (MC) simulated datasets were created here in order to explore “pathologies” of multilevel PCA (mPCA), where mPCA with two levels is equivalent to bgPCA. The first set of MC experiments involved 300 uncorrelated normally distributed variables, whereas the second set of MC experiments used correlated multivariate MC data describing 3D facial shape. We confirmed previous results of other researchers that indicated that bgPCA (and so also mPCA) can give a false impression of strong differences in component scores between groups when there is none in reality. These spurious differences in component scores via mPCA reduced strongly as the sample sizes per group were increased. Eigenvalues via mPCA were also found to be strongly effected by imbalances in sample sizes per group, although this problem was removed by using weighted forms of covariance matrices suggested by the maximum likelihood solution of the two-level model. However, this did not solve problems of spurious differences between groups in these simulations, which was driven by very small sample sizes in one group here. As a “rule of thumb” only, all of our experiments indicate that reasonable results are obtained when sample sizes per group in all groups are at least equal to the number of variables. Interestingly, the sum of all eigenvalues over both levels via mPCA scaled approximately linearly with the inverse of the sample size per group in all experiments. Finally, between-group variation was added explicitly to the MC data generation model in two experiments considered here. Results for the sum of all eigenvalues via mPCA predicted the asymptotic amount for the total amount of variance correctly in this case, whereas standard “single-level” PCA underestimated this quantity.
Light Absorption Enhancement and Laser-Induced Damage Ability Improvement of AA 6061 with Non-porous Alumina /CdSe@Al2O3/SiO2 Functional Gradient Films
Authors: Yin Jiaheng , Lu Lihua , Cui Yaowen , Cao Yongzhi , Du Yunlong
Published: January 2022

Numerical calculations of ultraviolet to near-infrared absorption spectra by cadmium selenide quantum dots (CdSe QDs) doped in anodic aluminum oxide pores were performed using a finite-difference time-domain model. The height, diameter, and periodic spacing of the pores were optimized. Light absorption by the dots was enhanced by increasing the height and decreasing the diameter of the pores. When the height was less than 1 μm, visible light absorption was enhanced as the spacing was reduced from 400 nm to 100 nm. No enhancement was observed for heights greater than 6 μm. Finally, the optical mode coupling of the aluminum oxide and the quantum dots was enhanced by decreasing the pore diameter and periodic spacing, and increasing the height. Laser ablation verified light absorption enhancement by the CdSe QDs. The experiment verified the improvement of the laser-induced damage ability with wavelength of 355-nm after aluminum alloy 6061 coated with functional films, which was fabricated based on numerical calculations.
Up-And-Down γ-Synuclein Transcription in Dopamine Neurons Translates Into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice
Authors: Pavia-Collado Rubén , Rodríguez-Aller Raquel , Alarcón-Arís Diana , Miquel-Rio Lluís , Ruiz-Bronchal Esther , Paz Verónica , Campa Leticia , Galofré Mireia , Sgambato Véronique , Bortolozzi Analia
Published: January 2022

The synuclein family consists of α-, β-, and γ-Synuclein (α-Syn, β-Syn, and γ-Syn), expressed in the neurons and concentrated in synaptic terminals. While α-Syn is at the center of interest due to its implication in the pathogenesis of Parkinson’s disease (PD) and other synucleinopathies, limited information exists on the other members. The current study aimed at investigating the biological role of γ-Syn controlling the midbrain dopamine (DA) function. We generated two different mouse models with i) γ-Syn overexpression induced by an adeno-associated viral vector and ii) γ-Syn knockdown induced by a ligand-conjugated antisense oligonucleotide, to modify the endogenous γ-Syn transcription levels in midbrain DA neurons. The progressive overexpression of γ-Syn decreased DA neurotransmission in the nigrostriatal and mesocortical pathways. In parallel, mice evoked motor deficits in the rotarod and impaired cognitive performance as assessed by novel object recognition, passive avoidance, and Morris water maze tests. Conversely, acute γ-Syn knockdown selectively in DA neurons facilitated forebrain DA neurotransmission. Importantly, modifications in γ-Syn expression did not induce the loss of DA neurons or changes in α-Syn expression. Collectively, our data strongly suggest that DA re-lease/re-uptake processes in the nigrostriatal and mesocortical pathways are partially dependent on SNc/VTA γ-Syn transcription levels, and are linked to modulation of DA transporter function, similar to α-Syn.
Disabled Children in Disaster Management
Authors: Narayan Sumit
Published: January 2022

Disabled children have a wide range of impairments, talents, and capacities, which collide with a wide range of circumstances and societal attitudes. The following article discusses disaster management in the context of disabled children. Disaster, disability and its management is discussed in the context of international practices in general and suited to India in particular. The research follows a review of the United States National Commission on Children and Disaster and its extrapolations to India. In addition to this Disaster Medicine as one approach to Disaster Management concerning disabled children has been explored. The research concludes that the understanding of particular issues of Children with disabilities as one stakeholder and their capacity to engage, as well as a shift in mindset and power relations in which children with disabilities contribute to DRR projects, are fundamental to disability-inclusive DRR.
Proactive Variant Effect Mapping to Accelerate Genetic Diagnosis for Pediatric Cardiac Arrest
Authors: Floyd Brendan , Weile Jochen , Kannankeril Prince , Glazer Andrew , Reuter Chloe , MacRae Calum , Ashley Euan , Roden Dan , Roth Frederick , Parikh Victoria
Published: January 2022

While genetic testing is becoming standard of care for patients with potentially inherited cardiovascular disease, the prevalence of uncertain results severely limits its utility. One promising approach is to generate variant effect maps that report the function of all possible variants in a gene prospectively. The proactive clinical application of these maps is nascent, and requires careful integration with current American College of Medical Genetics guidelines for variant interpretation. Here, we describe three pediatric cases of cardiac arrest or sudden cardiac death with variants of uncertain significance in calmodulin genes. We demonstrate the prospective clinical utility of a calmodulin variant effect map to inform variant interpretation, and therefore diagnosis and family care, in each case. This study was approved by the Stanford University and Vanderbilt University Medical Center IRBs. Consent was waived based on low risk of de-identified retrospective data collection per the IRB.
Wind Farm Noise Management Based on Determinants of Annoyance
Authors: van den Berg Frits
Published: January 2022

Wind energy in Europe is aimed to grow at a steady, high pace. Wind turbine noise is an important issue for residents. Environmental noise management aims to reduce the exposure of the population, usually based on acoustics and restricted to a limited number of sources (such as transportation or industry) and sound descriptors (such as Lden). Individual perceptions are taken into account only at an aggregate, statistical level (such as percentage of exposed, annoyed or sleep-disturbed persons in the population). Individual perceptions and reactions to sound vary in intensity and over different dimensions (such as pleasure/fear or distraction). Sound level is in fact a weak predictor of the perceived health effects of sound. The positive or negative perception of the sound (source) is a better predictor of its effects. This article aims to show how the two perspectives (based on acoustics and on perception) can lead to a combined approach in the management of environmental sound. In this approach the reduction of annoyance, not primarily of level, is the main aim. An important aspect in this approach is what a sound means to people: does it lead to anxiety or worry, is it appropriate? The available knowledge will be applied to wind farm management: planning as well as operation.
Changes in Prescribing Antithrombotic Therapy in Patients with Atrial Fibrillation in the Multidisciplinary Hospital in Volgograd from 2012 to 2020
Authors: Gerasimenko A. S. , Shatalova O. V. , Gorbatenko V. S. , Petrov V. I.
Published: January 2022

Aim. To study the frequency of prescribing antithrombotic agents in patients with non-valvular atrial fibrillation (AF) in real clinical practice, to evaluate changes of prescriptions from 2012 till 2020.

Material and methods. The medical records of inpatients (Form 003/y) with the diagnosis AF, hospitalized in the cardiological department were analyzed. According to the inclusion criteria, the patients were over 18 years of age, established diagnosis of non-valvular AF. There were two exclusion criteria: congenital and acquired valvular heart disease and prosthetic heart valves. In retrospective analysis we have included 263 case histories in 2012, 502 ones in 2016 and 524 in 2020. CHA2DS2-VASc score was used for individual stroke risk assessment in AF. The rational use of the antithrombotic therapy was evaluated according with current clinical practice guidelines at analyzing moment.

Results. During period of observation the frequency of antiplatelet therapy significantly decreased from 25,5% to 5,5% (р<0.001), decreased the frequency of administration of warfarin from 71,9% to 18,3% (р<0.001). The frequency of use of direct oral anticoagulants increased in 2020 compared to 2016 (р<0.001). For patients with a high risk of stroke anticoagulant therapy was administered in 71.8% of cases in 2012, 88.5% in 2016 and 92.5% in 2020. Before discharge from hospital majority of patients (72%) achieved a desired minimum international normalized ratio (INR) from 2.0 to 3.0 in 2012. In 2016 and 2020 an only 33% and 40.6% of patients achieved INR (2.0-3.0).

Conclusion. Doctors have become more committed to following clinical guidelines during the period of the investigation. In 2020 antithrombotic therapy for atrial fibrillation was suitable according to current clinical guidelines.
Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial Fibrillation
Authors: Pavlova T. V.
Published: January 2022

The increase in the life expectancy of the population  is accompanied by an increase in the prevalence of diseases for which old and senile age are risk factors. Atrial fibrillation (AF) and chronic kidney disease (CKD) are two diseases that can coexist in a patient. The risk of ac thromboembolic and hemorrhagic events in this case increases due to the mutual aggravating influence of these diseases. In addition,  these patients have a high incidence of coronary  events, and cardiovascular complications are the main cause of death in patients with AF and CKD. Consequently, such patients require an integrated  approach  to treatment,  and their management is a complex  clinical task. The direct oral anticoagulant rivaroxaban has been most studied in a population  of comorbid  AF and CKD  patients and has proven a high efficacy and safety profile in these patients in randomized controlled trials. In addition,  rivaroxaban has shown  a significant  reduction in the risk of myocardial  infarction  in various patients,  as well as the possibility of preserving renal function to a greater extent compared  with warfarin therapy, and a possible positive effect on reducing  the risk of cognitive impairment.  A single dosing  regimen  can improve adherence  to treatment,  which is one of the key conditions  for achieving  the above effects. Thus, these factors make it possible to achieve comprehensive protection of comorbid  patients with AF and CKD.
VOLLEY BALL PASSING LEARNING MODEL FOR STUDENTS AGE 11-12 YEARS
Authors: Fitriani Aida , Widiastuti  , Hernawan
Published: January 2022

The purpose of this study was to produce a product of Learning Passing Learning Model Age 11-12 Years in Elementary School. The learning model is expected to help teachers during the physical education learning process, especially in volleyball. This study uses the ADDIE method. The results of the study resulted in a product in the form of a Passing Learning Model for the Age of 11-12 Years which had been validated and revised by 22 experts. Data were collected through documentation, interviews, and observations. Data analysis was done descriptively. The results of the study were in the form of a Passing Learning Model book for 11-12 Years Old. Based on the results of the study, it was proven that the Passing Learning Model for the Age of 11-12 Years could be developed and applied in volleyball learning in elementary schools. The Passing Learning Model of 11-12 years old can make a positive contribution in supporting the achievement of goals in physical education learning in elementary schools, because besides being able to improve volleyball under-passing skills, students can be motivated to do a variety of learning
The Effect Of Jigsaw Cooperative Learning Model Aided With Interactive Multimedia Upon Learning Outcome Of On-Guard Position On Pencak Silat Course
Authors: Sudiana I Ketut , Suwiwa I Gede
Published: January 2022

This study aimed at analyzing the effect of Jigsaw Cooperative Learning Model aided with interactive multimedia upon learning outcome of on-guard position on the theory and practice of Pencak Silat course. This is a pre-experimental study using one group pretest-posttest design. This study was conducted Sport Hall of Sport and Health Faculty in Jinengdalem Campus. The amount of the sample was 25 students. The variables consisted of independent variable that was the jigsaw cooperative learning model aided with interactive multimedia and the dependent variable was the learning outcome. The data collection technique was performance test of the basic on-guard position of Pencak Silat. Data were analyzed by using nonparametric inferential statistic in form of Wilcoxon Sign Rank Test which was used to analyse the differences of pre-test and post-test scores. The research finding showed that there were significant differences of on-guard position learning outcome on the course theory and practice of Pencak Silat course before and after the implementation of jigsaw cooperative learning model aided with interactive multimedia (Z = 4.378; p = 0.000). Based on the result of Wilcoxon Sign Rank Test/Wilcoxon Match Pair Test, it was found that there was difference of on-guard position on Pencak Silat course before and after the implementation of Jigsaw cooperative learning model assisted with interactive multimedia. The after implementation/posttest mean score was (96.86) higher than before implementation/pre-test mean score (43.93) of Jigsaw cooperative learning model assisted with interactive multimedia.
GROUNDSTROKE TRAINING MODEL BASED ON SITUATION GAME FOR FIELD TENNIS ATHLETES AGED 12-14 YEARS
Authors: Zuhra Divya , Junaidi  , Nofi Marlina Siregar
Published: January 2022

This study aims to create a game situation-based groundstroke forehand and groundstroke backhand training model for tennis athletes aged 12-14 years and improve forehand and backhand skills using a game situation-based groundstroke training model for athletes aged 12-14 years. The research method used is the Research & Development Research & Development (R&D) Borg and Gall method. Subjects studied were 15 people and were athletes aged 12-14 years. The results of the pre-test test obtained an average of 31.73. Then, the post-test obtained an average of 40.00. The exercise correlation coefficient before and after the exercise model was given was 0.946 with a p-value of 0.00 < 0.05, so the conclusion was significant. In the mean difference test with SPSS, the mean = 8.26667 shows the difference between the pre-test and post-test, the result of t-count = 26,183, df = 19 and p-value = 0.00<0.05, which means there is a significant difference between before and after being given game situation based groundstroke training model treatment. Based on these results, it can be concluded that the game situation-based groundstroke training model for tennis athletes at the age of 12-14 years is effective and can improve the forehand groundstroke.
LA CONTINUIDAD DEL REVISOR FISCAL VULNERA LA INDEPENDENCIA FRENTE A LAS EMPRESAS
Authors:   Corporación Universitaria Republicana, CAPERA LEIDY , CARDENAS JEIMY , MANCIPE PAULA
Published: January 2022

The figure of the tax auditor of the public accountant is designated by the state to give public faith and generate confidence in the market about the transparency of the company’s operations before the users of the information. However, in recent years its image and importance has been weakened due to the strong growth of those of professionals who have been involved in fraud and corruption either by their participation or by omission of their duties and obligations established in the standards National and international. This article seeks to support with figures the impact that continuity has on the mental independence of the fiscal reviewer in the exercise of his profession.
EMPODERAMIENTO Y RUTAS DE ATENCIÓN EN CASOS DE VIOLENCIA INTRAFAMILIAR EN LA LOCALIDAD DE ENGATIVA
Authors:   Corporación Universitaria Republicana, GALINDO MARIA , MAYORGA MARIA , PARRADO WENDY
Published: January 2022

This article aims to learn about the different problems faced by people victims of domestic violence, specifically the multiple attacks that in most cases are the product of their spouses or permanent partners. The reason why interest arises to address this issue that has been one of the main causes of dysfunction of family dynamics. Institutions and support networks can play a key role in separating women, children, and adolescents from the cycle of violence as long as the service network and service flows are organized. Propose to empower victims of domestic violence against the need to know the routes and measures of care.
MECANISMOS DE REPARACIÓN A LAS VÍCTIMAS DEL CONFLICTO ARMADO EN EL MARCO JURÍDICO DE LA JUSTICIA TRANSICIONAL Y LOS DESAFÍOS FRENTE A SU IMPLEMENTACIÓN
Authors:   Corporación Universitaria Republicana, MONTES DEISI , PEREZ ESPERALDA , TAVERA RUTH
Published: January 2022

Colombia is a country that has been characterized for living in an internal armed conflict by decades, the conflict has been left an untold balance of victims who has been exposed to every possible kind of cruelty, setting up a violation to theirs humans rights. It is therefore that the government has been adopted mechanics to make disappear the effects of the violations and make the victims get back to the point where there is no violation, nonetheless the measure that has been adopted, are inefficient and a lot of times ineffective, because there is converging factors like the unwillingness of the government and their institutions.
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
Authors: Hansen Justine , Shafiei Golia , Markello Ross , Smart Kelly , Cox Sylvia , Wu Yanjun , Gallezot Jean-Dominique , Aumont Etienne , Servaes Stijn , Scala Stephanie , DuBois Jonathan , Wainstein Gabriel , Bezgin Gleb , Funck Thomas , Schmitz Taylor , Spreng R. Nathan , Soucy Jean-Paul , Baillet Sylvain , Guimond Synthia , Hietala Jarmo , Bedard Marc-Andre , Leyton Marco , Kobayashi Eliane , Rosa-Neto Pedro , Palomero-Gallagher Nicola , Shine James , Carson Richard , Tuominen Lauri , Dagher Alain , Misic Bratislav
Published: January 2022

Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography scans in >1,200 healthy individuals to construct a whole-brain 3-D normative atlas of 18 receptors and transporters across 9 different neurotransmitter systems. We find that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncover a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we find both expected and novel associations between receptor distributions and cortical thinning patterns across 13 disorders. We replicate all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.
Myopathy mutations in DNAJB6 slow conformer specific substrate processing that is corrected by NEF modulation
Authors: Bhadra Ankan , Rau Michael , Daw Jil , Fitzpatrick James , Weihl Conrad C. , True Heather
Published: January 2022

Molecular chaperones, or heat shock proteins (HSPs), protect against the toxic misfolding and aggregation of proteins. As such, mutations or deficiencies within the chaperone network can lead to disease. In fact, dominant mutations in DNAJB6 (Hsp40/Sis1), an Hsp70 co-chaperone, leads to a protein aggregate myopathy termed Limb-Girdle Muscular Dystrophy Type D1 (LGMDD1). DNAJB6 client proteins and co-chaperone interactions in skeletal muscle are not known. Here, we used the yeast prion model client in conjunction with in vitro chaperone activity assays to gain mechanistic insights, and found that LGMDD1 mutants affect Hsp40 functions. Strikingly, the mutants changed the structure of client protein aggregates, as determined by altered distribution of prion strains. They also impair the Hsp70 ATPase cycle, dimerization, and substrate processing and consequently poison the function of wild-type protein. These results define the mechanisms by which LGMDD1 mutations alter chaperone activity and provide avenues for therapeutic intervention.
A Novel Normalization Algorithm to Facilitate Pre-Assessment of Covid-19 Disease from Chest X-ray Image and its FPGA implementation
Authors: Yaman Sertaç , Karakaya Barış , erol yavuz
Published: January 2022

COVID-19 is still a fatal disease, which has threatened all people by affecting the human lungs. Chest X-Ray or computed tomography (CT) imaging is commonly used to make a fast and reliable medical investigation to detect the COVID-19 virus from these medical images is remarkably challenging because it is a full-time job and prone to human errors. In this paper, a new normalization algorithm that consists of Mean-Variance-Softmax-Rescale (MVSR) processes respectively is proposed to provide facilitation pre-assessment and diagnosis Covid-19 disease. In order to show the effect of MVSR normalization technique on image processing, the algorithm is applied to chest X-ray images. Therefore, the normalized X-ray images with MVSR are used to recognize via one of the neural network models as known Convolutional Neural Networks (CNNs). At the implementation stage, the MVSR algorithm is executed on MATLAB environment, then it is implemented on FPGA platform. All the arithmetic operations of the MVSR normalization are coded in VHDL with the help of fixed-point fractional number representation format. The experimental platform consists of Zynq-7000 Development Board and VGA monitor to display the both original X-ray and MVSR normalized image. The CNN model is constructed and executed using Anaconda Navigator interface with python language. Based on the results of this study, infections of Covid-19 disease can be easily diagnosed for MVSR normalized image. The proposed MVSR normalization makes the accuracy of CNN model increase from 83.01%, to 96.16% for binary class of chest X-ray images.
Effects of mixtures containing chlordecone and a dechlorinated by-product on hydra regeneration capacity: use of experimental design to evaluate the toxicity risk associated with remediation programs in long-lasting polluted areas
Authors: Moreau Xavier , Claeys-Bruno Magalie , Andraud Jean-Pascal , Macarie Hervé , Martínez Daniel E , Robin Maxime , Sergent Michelle , De Jong Laetitia
Published: January 2022

Chlordecone (CLD), an obsolete insecticide, used in the French West Indies between 1972 and 1993, is persistent in the environment but can be dechlorinated either chemically or under the action of microorganisms. Therefore, if soil remediation programs based on these processes are implemented in areas still contaminated today, those will see their concentrations of dechlorinated derivatives increase and these compounds will be also found in freshwater by streaming, leaching and erosion processes. The purpose of the present study was to evaluate, at environmental concentrations, the toxic effects of mixtures of chlordecone and a three-chlorine substituted byproduct. A hydra clone, which has been confirmed to be Hydra vulgaris Pallas, 1766 has been retained for bioassays where the toxicity has been evaluated by regeneration capacity during exposure. Exposure to mixtures is complex to investigate by classical methods, therefore, an experimental design associated to a mathematical model has been used to predict the effects of all the mixtures and to detect the toxic influence of each compound. The predictive model is discussed regarding the stochastic “endocrine disruptor effect” of CLD. At probable environmental concentrations of the compounds in the mixture, results show that impairment of regeneration capacity is explained mostly by the presence of CLD in the mixtures and support the implementation of remediation programs aimed at dechlorination of this persistent organochlorine pesticide.
Polynomial Mendelian Radomization reveals widespread
non-linear causal effects in the UK Biobank
Authors: Sulc Jonathan , Sjaarda Jennifer , Kutalik Zoltan
Published: January 2022

Causal inference is a critical step in improving our understanding of biological processes and Mendelian randomisation (MR) has emerged as one of the foremost methods to efficiently interrogate diverse hypotheses using large-scale, observational data from biobanks. Although many extensions have been developed to address the three core assumptions of MR-based causal inference (relevance, exclusion restriction, and exchangeability), most approaches implicitly assume that any putative causal effect is linear. Here we propose PolyMR, an MR-based method which provides a polynomial approximation of an (arbitrary) causal function between an exposure and an outcome. We show that this method provides accurate inference of the shape and magnitude of causal functions with greater accuracy than existing methods. We applied this method to data from the UK Biobank, testing for effects between anthropometric traits and continuous health-related phenotypes and found most of these
(84%) to have causal effects which deviate significantly from linear. These deviations ranged from slight attenuation at the extremes of the exposure distribution, to large changes in the
magnitude of the effect across the range of the exposure (e.g. a 1 kg/m2 change in BMI having stronger effects on glucose levels if the initial BMI was higher), to non-monotonic causal relationships (e.g. the effects of BMI on cholesterol forming an inverted U shape). Finally, we show that the linearity assumption of the causal effect may lead to the misinterpretation of health risks at the individual level or heterogeneous effect estimates when using cohorts
with differing average exposure levels.
Distribution characteristics of microplastics in the soil of mangrove restoration wetland and the effects of microplastics on soil characteristics
Authors: Hu Bo , Guo Peiyong , Han Siyu , Jin Yifan , Nan Yiting , Deng Jun , He Junming , Wu Yaqing , Chen Sijia
Published: January 2022

Microplastics that enter the soil environment are transformed by migration and can affect soil properties, which in turn have an impact on soil function and biodiversity. In this study, we investigated the distribution of soil microplastics at different planting densities and their effects on soil properties in a mangrove restoration wetland. The results showed that the average abundance of soil microplastics in the study area was 2177.5 n/500g, with the largest proportion of 0.038-0.05 mm diameter microplastics accounting for 70.9% and the rest of the diameter microplastics accounting for less than 20%, indicating that the smaller the diameter microplastics are easy to accumulate in the wetland soil. The abundance of microplastics in the restored area by planting density was ranked as 0.5×0.5m > 1.0×0.5m > 1.0×1.0m > control area. Three microplastics, polyethylene terephthalate (PET, accounted for 52%), polyethylene (PE, accounted for 24%), and polypropylene (PP, accounted for 15%), were the most prevalent and dominant microplastics in the soils of the area. SEM images showed that fractures, tears, EDS spectroscopy showed that a large number of metals were detected on the surface of microplastics. PET can influence the distribution of soil particle size due to its adsorptive viscosity, which may affect soil structure. Apart from soil pH, all other physicochemical factors changed significantly in response to PET. Besides, the results of the CV analysis reflect that soils in vegetated areas are more susceptible to the effects of PET than bare ground soils resulting in greater variability in the properties.
Integrated Simulation Modeling Approach for Investigating Pore Water Pressure Induced Landslides
Authors: Beegum Sahila , Jainet P J , Emil Dawn , Sudheer K P , Das Saurav
Published: January 2022

Soil pore water pressure analysis is crucial for understanding landslide initiation and prediction. However, field-scale transient pore water pressure measurements are complex. This study investigates the integrated application of simulation models (HYDRUS-2D/3D and GeoStudio–Slope/W) to analyze pore water pressure-induced landslides. The proposed methodology is illustrated and validated using a case study (landslide in India, 2018). Model simulated pore water pressure was correlated with the stability of hillslope, and simulation results were found to be co-aligned with the actual landslide that occurred in 2018. Simulations were carried out for natural and modified hill slope geometry in the study area. The volume of water in the hill slope, temporal and spatial evolution of pore water pressure, and factor of safety were analysed. Results indicated higher stability in natural hillslope (factor of safety of 1.243) compared to modified hill slope (factor of safety of 0.946) despite a higher pore water pressure in the natural hillslope. The study demonstrates the integrated applicability of the physics-based models in analyzing the stability of hill slopes under varying pore water pressure and hill slope geometry and its accuracy in predicting future landslides.
The interactive effects of pre-pregnancy body mass index, thyroid function, and blood lipid levels on the risk of gestational diabetes mellitus: a crossover analysis
Authors: Wang Ying , Lu Sha , Xu Xianrong , Zhang Lijun , Yang Jun , Hu Wensheng
Published: January 2022

Background

Studies have demonstrated the associations between pre-pregnancy obesity, thyroid dysfunction, dyslipidemia, and increased risk of gestational diabetes mellitus (GDM) in pregnant women. This study was designed to investigate whether and to what extent, the interactions between these factors contribute to the risk of GDM.
Methods

A case-control study of 232 GDM cases and 696 controls was conducted among pregnant women from Hangzhou, China. Multiple logistic regression analysis was applied to identify independent risk factors of GDM. Crossover analysis was performed to assess the interactive effects of pre-pregnancy body mass index (pBMI), thyroid hormones, blood lipid profiles on the risk of GDM. The indexes including attributable proportion (AP) to the interaction and the relative excess risk due to interaction (RERI) were calculated.
Results

Chinese pregnant women with pBMI > 23 kg/m2 (adjusted: OR=4.162, P<0.001), high triglyceride levels (> 2.30 mmol/L) (adjusted: OR=1.735, P<0.001) and the free triiodothyronine/free thyroxine (FT3/FT4) ratio ≥0.502 (OR=4.162, P<0.001) have significantly increased risk of GDM. Crossover analysis indicated that there were significant interactions between pre-pregnancy overweight/obesity and FT3/FT4 ≥0.502(AP=0.550, P<0.001; RERI=7.586, P=0.009), high TG levels and FT3/FT4≥0.502 (AP=0.348, 95%CI=0.081~0.614, P=0.010; RERI =2.021, 95%CI=0.064~3.978, P=0.043) on the risk of GDM.
Conclusion

The interactions between pBMI and FT3/FT4 ratio, TG level, and FT3/FT4 ratio may have significant impacts on the risk of GDM in pregnant women. Such findings may help improve our understanding of the pathogenesis of GDM as well as develop comprehensive strategies for the management of GDM.