bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial–Numerical Magnitude Estimation Mediates Early Sex Differences in the Use of Advanced Arithmetic Strategies
Authors: Vasilyeva Marina , Laski Elida V. , Casey Beth M. , Lu Linxi , Wang Muanjing , Cho Hyun Young
Published: May 2023

An accumulating body of literature points to a link between spatial reasoning and mathematics learning. The present study contributes to this line of research by investigating sex differences both in spatial representations of magnitude and in the use of arithmetic strategies, as well as the relation between the two. To test the hypothesis that sex differences in spatial–numerical magnitude knowledge mediate sex differences in the use of advanced strategies (retrieval and decomposition), two studies were conducted. Study 1 included 96 US first graders (53% girls); Study 2 included 210 Russian first graders (49% girls). All participants completed a number line estimation task (a spatially based measure of numerical magnitude knowledge) and an arithmetic strategy task (a measure of strategy choice). The studies showed parallel results: boys produced more accurate numerical magnitude estimates on the number line estimation task and used advanced strategies more frequently on the arithmetic task. Critically, both studies provide support for the mediation hypothesis (although there were some differences in the pattern obtained for the two strategies). The results are discussed in the context of broader research about the relation between spatial and mathematical skills.
Knowledge-Transfer-Based Bidirectional Vessel Monitoring System for Remote and Nearshore Images
Authors: Li Jiawen , Yang Yun , Li Xin , Sun Jiahua , Li Ronghui
Published: May 2023

Vessel monitoring technology involves the application of remote sensing technologies to detect and identify vessels in various environments, which is critical for monitoring vessel traffic, identifying potential threats, and facilitating maritime safety and security to achieve real-time maritime awareness in military and civilian domains. However, most existing vessel monitoring models tend to focus on a single remote sensing information source, leading to limited detection functionality and underutilization of available information. In light of these limitations, this paper proposes a comprehensive ship monitoring system that integrates remote satellite devices and nearshore detection equipment. The system employs ResNet, a deep learning model, along with data augmentation and transfer learning techniques to enable bidirectional detection of satellite cloud images and nearshore outboard profile images, thereby alleviating prevailing issues such as low detection accuracy, homogeneous functionality, and poor image recognition applicability. Empirical findings based on two real-world vessel monitoring datasets demonstrate that the proposed system consistently performs best in both nearshore identification and remote detection. Additionally, extensive supplementary experiments were conducted to evaluate the effectiveness of different modules and discuss the constraints of current deep learning-based vessel monitoring models.
Antifungal Susceptibility of Oral Candida Isolates from Mother-Infant Dyads to Nystatin, Fluconazole, and Caspofungin
Authors: Alkhars Naemah , Gaca Anthony , Zeng Yan , Al-Jallad Nisreen , Rustchenko Elena , Wu Tong , Eliav Eli , Xiao Jin
Published: May 2023

The carriage of Candida albicans in children’s oral cavities is associated with a higher risk for early childhood caries, so controlling this fungus in early life is essential for preventing caries. In a prospective cohort of 41 mothers and their children from 0 to 2 years of age, this study addressed four main objectives: (1) Evaluate in vitro the antifungal agent susceptibility of oral Candida isolates from the mother-child cohort; (2) compare Candida susceptibility between isolates from the mothers and children; (3) assess longitudinal changes in the susceptibility of the isolates collected between 0 and 2 years; and (4) detect mutations in C. albicans antifungal resistance genes. Susceptibility to antifungal medications was tested by in vitro broth microdilution and expressed as the minimal inhibitory concentration (MIC). C. albicans clinical isolates were sequenced by whole genome sequencing, and the genes related to antifungal resistance, ERG3, ERG11, CDR1, CDR2, MDR1, and FKS1, were assessed. Four Candida spp. (n = 126) were isolated: C. albicans, C. parapsilosis, C. dubliniensis, and C. lusitaniae. Caspofungin was the most active drug for oral Candida, followed by fluconazole and nystatin. Two missense mutations in the CDR2 gene were shared among C. albicans isolates resistant to nystatin. Most of the children’s C. albicans isolates had MIC values similar to those from their mothers, and 70% remained stable on antifungal medications from 0 to 2 years. For caspofungin, 29% of the children’s isolates showed an increase in MIC values from 0 to 2 years. Results of the longitudinal cohort indicated that clinically used oral nystatin was ineffective in reducing the carriage of C. albicans in children; novel antifungal regimens in infants are needed for better oral yeast control.
Social Media Publishing Strategies of German Newspapers: Content Analysis of Sports Reporting on Social Networks by German Newspapers—Results of the 2021 Social Media International Sports Press Survey
Authors: Seeger Christof , Horky Thomas , Nieland Jörg-Uwe , English Peter
Published: May 2023

Newspaper sports departments in Germany are reacting to changes in social media by expanding their offerings and employing a variety of publishing and engagement strategies. In this constantly evolving media environment, it is important to understand how newsrooms utilize social media to inform their audiences. This study examines the approaches German newspapers apply to publishing sports content on social media, and outlines how users interact with these posts. In analyzing these aspects, this paper applies theoretical elements of agenda setting and audience engagement, gender in media, and quality and diversity of published content. Social media posts were examined across eight German publications, totaling 3633 posts from Twitter and Facebook. Results in the study, which is part of the global 2021 Social Media International Sports Press Survey, highlighted how most of the content published by German newspapers on social media aimed to redirect users to the publications’ websites. The findings also reflect how social media is used less as an editorial space and more as part of a campaign to increase the audience. These results demonstrate challenges for the quality of sports coverage distributed via social networks in Germany.
The Role of Zoos and Aquariums in Contributing to the Kunming–Montreal Global Biodiversity Framework
Authors: Moss Andrew , Vukelic Matea , Walker Susan L. , Smith Charlotte , Spooner Sarah L.
Published: May 2023

It is now well established that human-induced species extinctions and habitat degradation are currently occurring at unprecedented rates. To halt and reverse this decline, the international community adopted the Kunming–Montreal Global Biodiversity Framework (GBF), as part of the Kunming–Montreal Biodiversity Package, in December 2022. We clarify what this new framework means for conservation zoos and aquariums in their mission to prevent species extinction by highlighting areas of focus. We explain why it is necessary that conservation zoos and aquariums establish the appropriate mechanisms for contributing towards such a framework to help validate their role in the 21st Century. Conservation zoos and aquariums should be reassured that much of their work already fits within the GBF. However, the current mechanisms for individual zoos and aquariums to directly contribute to the implementation of the GBF mostly rely on close collaboration with individual national governments and/or are only possible at a national level. It is therefore critical that national, regional, and global zoo membership organisations take a leading role in championing the work of their members. Equally, adequately linking the efforts of zoos and aquariums to the national implementation of international instruments, such as the GBF, is imperative to ensure that these organizations’ contributions feed into the understanding we have of global progress towards the implementation of international instruments.
Rural Transformation Development and Its Influencing Factors in China’s Poverty-Stricken Areas: A Case Study of Yanshan-Taihang Mountains
Authors: Guo Yuanzhi , Zhong Wenyue
Published: May 2023

Rural China has undergone a rapid transformation in the past few decades, especially the poverty-stricken areas, making a historic leap from inadequate subsistence to full well-off status. Based on rural regional system theory, this study analyzes the connotation of rural transformation development (RTD), explores the spatio-temporal patterns of RTD in the Yanshan-Taihang Mountainous, and diagnoses its influencing factors using a geographically and temporally weighted regression model. The results show that RTD is a dynamic process of qualitative changes in rural regional systems based on the accumulation of quantitative changes of elements, and the key to its measurement lies in analyzing the coupling coordination degree between quantitative changes of elements. From 2000 to 2020, the rapid development of urban population share, non-agricultural industry share, construction land share and NDVI in the Yanshan-Taihang Mountains contributed to a leap in RTD status, and the proportion of counties in a coupling coordination state increased from 24.24% to 96.97%. Spatially, the RTD level in the Taihang Mountains was significantly superior to that in the Yanshan Mountains. Average years of schooling, road density, per capita GDP and urban–rural dual structure were the main influencing factors of RTD, of which the first three were positive factors and the last one presented a negative correlation. To promote RTD to a higher level, it is an urgent matter to boost the high-quality development of county economy and rural education, improve public transportation infrastructure and innovate the policy system.
Translating Multilingualism in Mira Nair’s Monsoon Wedding
Authors: Corrius Montse , Espasa Eva , Santamaria Laura
Published: May 2023

Linguistic diversity is present in many audiovisual productions and has given rise to fruitful research on translation of multilingualism and language variation. Monsoon Wedding (Mira Nair, 2001) is a prototypical film for translation analysis, since multilingualism is a recurrent feature, as the film dialogue combines English (L1) with Hindi and Punjabi (L3), which creates an effect of code-switching. This article analyses how the multilingualism and the cultural elements present in the source text (ST) have been transferred to the Spanish translated text (TT) La boda del monzón. The results show that in the Spanish dubbed and subtitled versions, few Indian cultural elements are left, and little language variation is preserved. Thus, L3 does not play a central role as it does in the source text. In the translation, only a few loan words from Hindi or Punjabi are kept, mainly from the domains of food and cooking, as well as terms of address and greetings, or words related to the wedding ceremony. The results also show that when L3 is not fully rendered in translation, otherness is still conveyed through image and music, thus (re)creating a different atmosphere for Spanish audiences.
Chromosome Painting in Cercopithecus petaurista (Schreber, 1774) Compared to Other Monkeys of the Cercopithecini Tribe (Catarrhini, Primates)
Authors: Milioto Vanessa , Sineo Luca , Dumas Francesca
Published: May 2023

The Cercopithecini tribe includes terrestrial and arboreal clades whose relationships are controversial, with a high level of chromosome rearrangements. In order to provide new insights on the tribe’s phylogeny, chromosome painting, using the complete set of human syntenic probes, was performed in Cercopithecus petaurista, a representative species of the Cercopithecini tribe. The results show C. petaurista with a highly rearranged karyotype characterized by the fission of human chromosomes 1, 2, 3, 5, 6, 8, 11, and 12. These results compared with the literature data permit us to confirm the monophyly of the Cercopithecini tribe (fissions of chromosomes 5 and 6), as previously proposed by chromosomal and molecular data. Furthermore, we support the monophyly of the strictly arboreal Cercopithecus clade, previously proposed by the molecular approach, identifying chromosomal synapomorphies (fissions of chromosomes 1, 2, 3, 11, 12). We also add additional markers that can be useful for deciphering arboreal Cercopithecini phylogeny. For example, the fission of chromosome 8 is synapomorphy linking C. petaurista, C. erythrogaster, and C. nictitans among the arboreal species. Finally, a telomeric sequence probe was mapped on C. petaurista, showing only classic telomeric signals and giving no support to a previous hypothesis regarding a link between interspersed telomeric sequences in high rearranged genomes.
Study on the Interface Microstructure of TaC/GCr15 Steel Surface Reinforced Layer Formed by In-Situ Reaction
Authors: Li Jilin , Li Ruixue , Xu Yunhua , Liu Zhuolin , Chen Le , Zhu Yao
Published: May 2023

In this study, a micro–nano TaC ceramic steel matrix reinforced layer was prepared by an in situ reaction between a pure tantalum plate and GCr15 steel. The microstructure and phase structure of the in situ reaction reinforced layer of the sample at 1100 °C and reaction time 1 h were characterized with FIB micro-section, TEM transmission, SAED diffraction pattern, SEM and EBSD. The phase composition, phase distribution, grain size, grain orientation and grain boundary deflection, phase structure and lattice constant of the sample were characterized in detail. The results show that the phase composition of the Ta sample is Ta, TaC, Ta2C and α-Fe. TaC is formed after Ta and carbon atoms meet, and the orientation changes in the X and Z directions. The grain size of TaC is widely in the range of 0~0.4 μm, and the angular deflection of TaC grain is not obvious. The high-resolution transmission structure, diffraction pattern and interplanar spacing of the phase were characterized, and the crystal planes of different crystal belt axes were determined. The study provides technical and theoretical support for further research on the preparation technology and microstructure of the TaC ceramic steel matrix reinforcement layer.
Bending Stability of Ferroelectric Gated Graphene Field Effect Transistor for Flexible Electronics
Authors: Hu Guangliang , Shen Yinchang , Shen Lvkang , Ma Chunrui , Liu Ming
Published: May 2023

In this work, we explored the potential of the ferroelectric gate of (Pb0.92La0.08)(Zr0.30Ti0.70)O3 (PLZT(8/30/70)) for flexible graphene field effect transistor (GFET) devices. Based on the deep understanding of the VDirac of PLZT(8/30/70) gate GFET, which determines the application of the flexible GFET devices, the polarization mechanisms of PLZT(8/30/70) under bending deformation were analyzed. It was found that both flexoelectric polarization and piezoelectric polarization exist under bending deformation, and their polarization direction is opposite under the same bending deformation. Thus, a relatively stable of VDirac is obtained due to the combination of these two effects. In contrast to the relatively good linear movement of VDirac under bending deformation of relaxor ferroelectric (Pb0.92La0.08)(Zr0.52Ti0.48)O3 (PLZT(8/52/48)) gated GFET, these stable properties of the PLZT(8/30/70) gate GFETs make them have great potential for applications in flexible devices.
Different Crystallization Behavior of Amorphous ITO Film by Rapid Infrared Annealing and Conventional Furnace Annealing Technology
Authors: Li Jiaming , Jiang Liangbao , Li Xiaoyu , Luo Junjie , Liu Jiaxi , Wang Minbo , Yan Yue
Published: May 2023

An amorphous indium tin oxide (ITO) film (Ar/O2 = 80:0.5) was heated to 400 °C and maintained for 1–9 min using rapid infrared annealing (RIA) technology and conventional furnace annealing (CFA) technology. The effect of holding time on the structure, optical and electrical properties, and crystallization kinetics of ITO films, and on the mechanical properties of the chemically strengthened glass substrates, were revealed. The results show that the nucleation rate of ITO films produced by RIA is higher and the grain size is smaller than for CFA. When the RIA holding time exceeds 5 min, the sheet resistance of the ITO film is basically stable (8.75 Ω/sq). The effect of holding time on the mechanical properties of chemically strengthened glass substrates annealed using RIA technology is less than that of CFA technology. The percentage of compressive-stress decline of the strengthened glass after annealing using RIA technology is only 12–15% of that using CFA technology. For improving the optical and electrical properties of the amorphous ITO thin films, and the mechanical properties of the chemically strengthened glass substrates, RIA technology is more efficient than CFA technology.
Isothermal Experiments on Steam Oxidation of Zr−Sn−Nb Alloy at 1050 °C: Kinetics and Process
Authors: Jiang Rui , Tang Dewen , Yang Chen , Wang Yanli , Zhang Lin , Lei Ming
Published: May 2023

The isothermal steam oxidation behavior of the Zr−Sn−Nb alloy at 1050 °C was studied. In this study, the oxidation weight gain of Zr−Sn−Nb samples with oxidation durations ranging from 100 s to 5000 s was calculated. The oxidation kinetic properties of the Zr−Sn−Nb alloy were obtained. The macroscopic morphology of the alloy was directly observed and compared. The microscopic surface morphology, cross-section morphology, and element content of the Zr−Sn−Nb alloy were analyzed using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and energy disperse spectroscopy (EDS). According to the results, the cross-sectional structure of the Zr−Sn−Nb alloy consisted of ZrO2, α-Zr(O), and prior-β. During the oxidation process, its weight gain versus oxidation time curve followed a parabolic law. The thickness of the oxide layer increases. Micropores and cracks gradually appear on the oxide film. Similarly, the thicknesses of ZrO2 and α-Zr versus oxidation time were in accordance with the parabolic law.
Design and Verification of a Novel Energy Harvester for Tire Pressure Monitoring Systems
Authors: Liu Wenjia , Qin Zhen , Lyu Sung-Ki
Published: May 2023

With the development of intelligent tires, the tire pressure monitoring system (TPMS) has become a standard safety feature in cars. However, the existing TPMS has limited ability to monitor tire pressure in real time due to the passive power supply device’s low power output. This work presents a conceptual design for a novel energy harvester for TPMS (NEH-TPMS) based on a mechanical structure to recover energy. The motion of the mechanical structure is driven by the deformation of the tire in contact with the ground. The energy is recovered and released by a spiral spring to accomplish the functions of power generation and charging. Mathematical models are created based on the NEH-TPMS’s movements. The simulation results indicate that the NEH-TPMS’s power generation capacity is greater than that of existing energy harvesters and can satisfy the TPMS’s power supply requirements. This work uses finite element analysis and hierarchical analysis to optimize the shape of the NEH-TPMS. The parameters of the spiral spring are optimized using simulated annealing and genetic algorithms. NEH-TPMS has been enhanced to provide greater energy storage capacity. Finally, a prototype was built to verify the structure’s feasibility. The experimental results are consistent with the simulated results. This NEH-TPMS offers an efficient means of enhancing the power generation efficiency of the passive power supply device for TPMS.
DNN-MLVEM: A Data-Driven Macromodel for RC Shear Walls Based on Deep Neural Networks
Authors: Solorzano German , Plevris Vagelis
Published: May 2023

This study proposes the DNN-MVLEM, a novel macromodel for the non-linear analysis of RC shear walls based on deep neural networks (DNN); while most RC shear wall macromodeling techniques follow a deterministic approach to find the right configuration and properties of the system, in this study, an alternative data-driven strategy is proposed instead. The proposed DNN-MVLEM is composed of four vertical beam-column elements and one horizontal shear spring. The beam-column elements implement the fiber section formulation with standard non-linear uniaxial material models for concrete and steel, while the horizontal shear spring uses a multi-linear force–displacement relationship. Additionally, three calibration factors are introduced to improve the performance of the macromodel. The data-driven component of the proposed strategy consists of a large DNN that is trained to predict the force–displacement curve of the shear spring and the three calibration factors. The training data is created using a parametric microscopic FEM model based on the multi-layer shell element formulation and a genetic algorithm (GA) that optimizes the response of the macromodel to match the behavior of the microscopic FEM model. The DNN-MVLEM is tested in two types of examples, first as a stand-alone model and then as part of a two-bay multi-story frame structure. The results show that the DNN-MVLEM is capable of reproducing the results obtained with the microscopic FEM model up to 100 times faster and with an estimated error lower than 5%.
Prediction of ECOG Performance Status of Lung Cancer Patients Using LIME-Based Machine Learning
Authors: Nguyen Hung Viet , Byeon Haewon
Published: May 2023

The Eastern Cooperative Oncology Group (ECOG) performance status is a widely used method for evaluating the functional abilities of cancer patients and predicting their prognosis. It is essential for healthcare providers to frequently assess the ECOG performance status of lung cancer patients to ensure that it accurately reflects their current functional abilities and to modify their treatment plan accordingly. This study aimed to develop and evaluate an AdaBoost classification (ADB-C) model to predict a lung cancer patient’s performance status following treatment. According to the results, the ADB-C model has the highest “Area under the receiver operating characteristic curve” (ROC AUC) score at 0.7890 which outperformed other benchmark models including Logistic Regression, K-Nearest Neighbors, Decision Trees, Random Forest, XGBoost, and TabNet. In order to achieve model prediction explainability, we combined the ADB-C model with a LIME-based explainable model. This explainable ADB-C model may assist medical professionals in exploring effective cancer treatments that would not negatively impact the post-treatment performance status of a patient.
Data-Driven Optimized Artificial Neural Network Technique for Prediction of Flyrock Induced by Boulder Blasting
Authors: Wang Xianan , Hosseini Shahab , Jahed Armaghani Danial , Tonnizam Mohamad Edy
Published: May 2023

One of the most undesirable consequences induced by blasting in open-pit mines and civil activities is flyrock. Furthermore, the production of oversize boulders creates many problems for the continuation of the work and usually imposes additional costs on the project. In this way, the breakage of oversize boulders is associated with throwing small fragments particles at high speed, which can lead to serious risks to human resources and infrastructures. Hence, the accurate prediction of flyrock induced by boulder blasting is crucial to avoid possible consequences and its’ environmental side effects. This study attempts to develop an optimized artificial neural network (ANN) by particle swarm optimization (PSO) and jellyfish search algorithm (JSA) to construct the hybrid models for anticipating flyrock distance resulting in boulder blasting in a quarry mine. The PSO and JSA algorithms were used to determine the optimum values of neurons’ weight and biases connected to neurons. In this regard, a database involving 65 monitored boulders blasting for recording flyrock distance was collected that comprises six influential parameters on flyrock distance, i.e., hole depth, burden, hole angle, charge weight, stemming, and powder factor and one target parameter, i.e., flyrock distance. The ten various models of ANN, PSO–ANN, and JSA–ANN were established for estimating flyrock distance, and their results were investigated by applying three evaluation indices of coefficient of determination (R2), root mean square error (RMSE) and value accounted for (VAF). The results of the calculation of evaluation indicators revealed that R2, values of (0.957, 0.972 and 0.995) and (0.945, 0.954 and 0.989) were determined to train and test of proposed predictive models, respectively. The yielded results denoted that although ANN model is capable of anticipating flyrock distance, the hybrid PSO–ANN and JSA–ANN models can anticipate flyrock distance with more accuracy. Furthermore, the performance and accuracy level of the JSA–ANN predictive model can estimate better compared to ANN and PSO–ANN models. Therefore, the JSA–ANN model is identified as the superior predictive model in estimating flyrock distance induced from boulder blasting. In the final, a sensitivity analysis was conducted to determine the most influential parameters in flyrock distance, and the results showed that charge weight, powder factor, and hole angle have a high impact on flyrock changes.
Polyvinyl Alcohol-Chitosan Scaffold for Tissue Engineering and Regenerative Medicine Application: A Review
Authors: Nathan Kavitha Ganesan , Genasan Krishnamurithy , Kamarul Tunku
Published: May 2023

Tissue engineering and regenerative medicine (TERM) holds great promise for addressing the growing need for innovative therapies to treat disease conditions. To achieve this, TERM relies on various strategies and techniques. The most prominent strategy is the development of a scaffold. Polyvinyl alcohol-chitosan (PVA-CS) scaffold emerged as a promising material in this field due to its biocompatibility, versatility, and ability to support cell growth and tissue regeneration. Preclinical studies showed that the PVA-CS scaffold can be fabricated and tailored to fit the specific needs of different tissues and organs. Additionally, PVA-CS can be combined with other materials and technologies to enhance its regenerative capabilities. Furthermore, PVA-CS represents a promising therapeutic solution for developing new and innovative TERM therapies. Therefore, in this review, we summarized the potential role and functions of PVA-CS in TERM applications.
Effect of Deployment and Harvest Date on Growth and High-Value Compounds of Farmed Alaria esculenta
Authors: Blanco Silvia , Sapatinha Maria , Mackey Mick , Maguire Julie , Paolacci Simona , Gonçalves Susana , Lourenço Helena Maria , Mendes Rogério , Bandarra Narcisa Maria , Pires Carla
Published: May 2023

Alaria esculenta is a brown seaweed farmed in many European countries for its biomass rich in useful bio compounds. This study aimed to identify the optimal growing season to maximise biomass production and quality. The seeded longlines of the brown seaweed were deployed in the southwest of Ireland in October and November 2019 and samples of the biomass were harvested in different dates, between March and June 2020. Biomass gain and composition, phenolic and flavonoid content (TPC and TFC) and biological activities (antioxidant and anti-hypertensive activities) of seaweed extracts prepared with Alcalase were evaluated. The biomass production was significantly higher for the line deployed in October (>20 kg·m−1). In May and June, an increasing amount of epiphytes was observed on the surface of A. esculenta. The protein content of A. esculenta varied between 11.2 and 11.76% and fat content was relatively low (1.8–2.3%). Regarding the fatty acids profile, A. esculenta was rich in polyunsaturated fatty acids (PUFA), especially in eicosapentaenoic acid (EPA). The samples analysed were very rich in Na, K, Mg, Fe, Mn, Cr and Ni. The content of Cd, Pb Hg was relatively low and below the maximum levels allowed. The highest TPC and TFC were obtained in extracts prepared with A. esculenta collected in March and levels of these compounds decreased with time. In general, the highest radical scavenging activities (ABTS and DPPH), as well as chelating activities (Fe2+ and Cu2+) were observed in early spring. Extracts from A. esculenta collected in March and April presented higher ACE inhibitory activity. The extracts from seaweeds harvested in March exhibited higher biological activity. It was concluded that an earlier deployment allows for maximising growth and harvest of biomass earlier when its quality is at the highest levels. The study also confirms the high content of useful bio compounds that can be extracted from A. esculenta and used in the nutraceutical and pharmaceutical industry.
Camptodactyly: From Embryological Basis to Surgical Treatment
Authors: Kloc Jan , Dzula Boris , Varga Ivan , Klein Martin , Steno Boris
Published: May 2023

Camptodactyly is a relatively rare hand deformity presenting as the proximal interphalangeal joint’s nontraumatic and progressive flexion contracture. Most cases are limited to the fifth finger. The severity and type of camptodactyly should be considered to optimize treatment. Since many structures at the finger base can be involved in the pathogenesis of the deformity, surgical treatment for this particular type of deformity is challenging. This paper aims to bring insight into camptodactyly’s pathogenesis and treatment options. We discuss the indication and pitfalls of surgical treatment options for particular camptodactyly types and present a case of a fourteen-year-old boy who was admitted to our department with proximal interphalangeal joint flexion contracture of the left fifth digit.
Denture Adhesive Utilization and Associated Factors among Dental Practitioners in the Eastern Province, Saudi Arabia
Authors: Gad Mohammed M. , Almusallam Mayyasah O. , Almarar Fadak H. , Al khaldi Haya O. , Aldossary Alhanoof K. , Almutairi Wejdan M. , Alghamdi Nawaf A. , Alssaialiy Yasser S. , Alghamdi Nawaf I. , Nazir Muhammad A.
Published: May 2023

Background: Denture adhesives (DAs) enhance denture retention and stability, thus improving functions of removable prostheses. However, the adverse effects of DAs on denture foundation area were also reported. The clinical use of DAs among dentists has not been investigated in Saudi Arabia. Therefore, this study aimed to evaluate utilization of DAs and associated factors among dental practitioners in Saudi Arabia. Methods: This cross-sectional study included dental professionals practicing in both public and private sectors in the Eastern Province of Saudi Arabia. A self-administered pilot tested questionnaire was distributed among participants. The questionnaire has questions related to demographic information, knowledge and awareness, and the utilization of DAs. Bivariate and multiple logistic regression analyses were performed. Results: The study included 279 participants with a response rate of 79.03%. The majority of participants (61.6%) were below 35 years of age, males (56.6%), general dentists (57.3%), and worked in the private sector (59.9%). Less than half of the participants (39.4%) used DAs in their dental practice, and 64.5% recommended using DAs when needed. The most reported complications of DAs included inflammation (58.40%), ulcers (35.10%), and whitish color (31.20%) of denture foundation area. A vast majority (83.90%) reported that DAs improve retention of the dentures. About 55.2% of the participants were taught about DAs in their undergraduate programs, 12.5% attended continuing education, and 21.5% updated their knowledge about DAs. Multiple logistic regression showed that those who attended continuing education activities (adjusted OR = 2.41, p = 0.036) and updated their knowledge about DAs (adjusted OR = 4.43, p = < 0.001) were significantly more likely to use DAs in their dental practice. Conclusion: A minority of dental practitioners used DAs in their practices. Attending continuing education programs and updating knowledge of DAs were significantly associated with DAs utilization.
Friction Stir Welding/Processing of Various Metals with Working Tools of Different Materials and Its Peculiarities for Titanium Alloys: A Review
Authors: Chumaevskii Andrey , Amirov Alihan , Ivanov Aleksey , Rubtsov Valery , Kolubaev Evgeny
Published: May 2023

A review of the state of research in the field of friction stir welding and processing has been carried out. The features of plastic flow in friction stir welding and their connection with the processes of adhesion friction are shown. The main direction of research is related to the features of friction stir welding of titanium alloys. Special attention is paid to the selection of working tool materials from various alloys for friction stir welding and the processing of titanium alloys. The main advantages and disadvantages of applying different types of tools for friction stir welding of titanium alloys are shown. Different mechanisms of tool wear in friction stir welding associated with the interaction of processed material and tools are demonstrated. Information on the influence of tool and material interaction at welding on the mechanical properties and operational characteristics of obtained joints is given.
Dynamic Modeling and Stability Prediction of Robot Milling Considering the Influence of Force-Induced Deformation on Regenerative Effect and Process Damping
Authors: Du Yuchao , Liang Zhiqiang , Chen Sichen , Huang Hao , Zheng Haoran , Gao Zirui , Zhou Tianfeng , Liu Zhibing , Wang Xibin
Published: May 2023

Undesirable chatter is one of the key problems that restrict the improvement of robot milling quality and efficiency. The prediction of chatter stability, which is used to guide the selection of process parameters, is an effective method to avoid chatter in robot milling. Due to the weak stiffness of the robot, deformation caused by milling forces becomes an unavoidable problem, which will change the tool–workpiece contact area and affect the stability prediction. However, it is often simplified and neglected. In this paper, a multipoint contact dynamic model of robot milling is established, which considers the influence of force-induced deformation on the regenerative effect and process damping. The tool–workpiece contact area is discretized into a finite number of nodes along the axial direction so that the force and deformation at each node can be calculated separately. The different contact forms of the tool–workpiece under different process parameters are discussed in different cases, and the interaction process between cutting force and force-induced deformation is analyzed in detail. An iterative strategy is used to calculate the deformation of each node and the result of the tool–workpiece contact boundary. Finally, chatter stability of robot milling is predicted by a fully discrete method. Robot milling experiments were carried out to verify the predicted results. The results show that force-induced deformation is an important factor improving the stability prediction accuracy of robot milling, and a more accurate prediction result can be obtained by simultaneously considering force-induced deformation and process damping.
Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital
Authors: Papanikolopoulou Amalia , Gargalianos-Kakolyris Panagiotis , Stoupis Athina , Moussas Nikos , Pangalis Anastasia , Theodoridou Kalliopi , Chronopoulou Genovefa , Pantazis Nikos , Kantzanou Maria , Maltezou Helena C. , Tsakris Athanasios
Published: May 2023

Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a life-threatening healthcare-associated infection affecting especially patients with immunosuppression and comorbidities. We investigated the association between the incidence of CRPA bacteremia, antibiotic consumption, and infection control measures in a hospital during 2013–2018. Methods: We prospectively recorded the incidence of CRPA bacteremia, antibiotic consumption, use of hand-hygiene solutions, and isolation rates of multidrug-resistant (MDR) carrier patients. Findings: The consumption of colistin, aminoglycosides, and third-generation cephalosporins decreased significantly in the total hospital and its divisions (p-value < 0.001 for all comparisons) while the consumption of carbapenems decreased significantly in the adults ICU (p-value = 0.025). In addition, the incidence of CRPA significantly decreased in the total hospital clinics and departments (p-values = 0.027 and 0.042, respectively) and in adults clinics and departments (p-values = 0.031 and 0.051, respectively), while in the adults ICU, the incidence remained unchanged. Increased isolation rates of MDR carrier patients, even two months before, significantly correlated with decreased incidence of CRPA bacteremia (IRR: 0.20, 95% CI: 0.05–0.73, p-value = 0.015) in the adults ICU. Interestingly, when the use of hand-hygiene solutions (alcohol and/or scrub) increased, the consumption of advanced, nonadvanced, and all antibiotics decreased significantly. Conclusion: In our hospital, multimodal infection control interventions resulted in a significant reduction of CRPA bacteremia, mostly due to the reduction of all classes of antibiotics.
Amino Acid-Derived Bacterial Metabolites in the Colorectal Luminal Fluid: Effects on Microbial Communication, Metabolism, Physiology, and Growth
Authors: Blachier François
Published: May 2023

Undigested dietary and endogenous proteins, as well as unabsorbed amino acids, can move from the terminal part of the ileum into the large intestine, where they meet a dense microbial population. Exfoliated cells and mucus released from the large intestine epithelium also supply nitrogenous material to this microbial population. The bacteria in the large intestine luminal fluid release amino acids from the available proteins, and amino acids are then used for bacterial protein synthesis, energy production, and in other various catabolic pathways. The resulting metabolic intermediaries and end products can then accumulate in the colorectal fluid, and their concentrations appear to depend on different parameters, including microbiota composition and metabolic activity, substrate availability, and the capacity of absorptive colonocytes to absorb these metabolites. The aim of the present review is to present how amino acid-derived bacterial metabolites can affect microbial communication between both commensal and pathogenic microorganisms, as well as their metabolism, physiology, and growth.
Immunisation with Transgenic L. tarentolae Expressing Gamma Glutamyl Cysteine Synthetase from Pathogenic Leishmania Species Protected against L. major and L. donovani Infection in a Murine Model
Authors: Topuz Ata Derya , Hussain Muattaz , Jones Michael , Best Jonathan , Wiese Martin , Carter Katharine Christine
Published: May 2023

Leishmaniasis is a protozoan disease responsible for significant morbidity and mortality. There is no recommended vaccine to protect against infection. In this study, transgenic Leishmania tarentolae expressing gamma glutamyl cysteine synthetase (γGCS) from three pathogenic species were produced and their ability to protect against infection determined using models of cutaneous and visceral leishmaniasis. The ability of IL-2-producing PODS® to act as an adjuvant was also determined in L. donovani studies. Two doses of the live vaccine caused a significant reduction in L. major (p < 0.001) and L. donovani (p < 0.05) parasite burdens compared to their respective controls. In contrast, immunisation with wild type L. tarentolae, using the same immunisation protocol, had no effect on parasite burdens compared to infection controls. Joint treatment with IL-2-producing PODS® enhanced the protective effect of the live vaccine in L. donovani studies. Protection was associated with a Th1 response in L. major and a mixed Th1/Th2 response in L. donovani, based on specific IgG1 and IgG2a antibody and cytokine production from in vitro proliferation assays using antigen-stimulated splenocytes. The results of this study provide further proof that γGCS should be considered a candidate vaccine for leishmaniasis.
Unveiling the Emergence and Genetic Diversity of OXA-48-like Carbapenemase Variants in Shewanella xiamenensis
Authors: Jiang Xueqi , Miao Beibei , Zhao Xiaofei , Bai Xuemei , Yuan Min , Chen Xia , Gong Xinyi , Liu Zeliang , Li Jie , Meng Shuang , Han Xiao , Li Juan
Published: May 2023

An increase in the carbapenem-hydrolyzing capacity of class D β-lactamase has been observed in strains of multiple species, posing a significant challenge to the control of antibiotic resistance. In this study, we aimed to investigate the genetic diversity and phylogenetic characteristics of new blaOXA-48-like variants derived from Shewanella xiamenensis. Three ertapenem-non-susceptible S. xiamenensis strains were identified, one isolated from the blood sample of an inpatient, the other two isolated from the aquatic environment. Phenotypic characterization confirmed that the strains were carbapenemase producers and exhibited antimicrobial resistance patterns to ertapenem, with some showing lower susceptibility to imipenem, chloramphenicol, ciprofloxacin, and tetracycline. No significant resistance to cephalosporins was observed. Sequence analysis revealed that one strain harbored blaOXA-181 and the other two strains harbored blaOXA-48-like genes, with open reading frame (ORF) similarities with blaOXA-48 ranging from 98.49% to 99.62%. The two novel blaOXA-48-like genes, named blaOXA-1038 and blaOXA-1039, respectively, were cloned and expressed in E. coli. The three OXA-48-like enzymes demonstrated significant hydrolysis activity against meropenem, and the classical β-lactamase inhibitor had no significant inhibitory effect. In conclusion, this study demonstrated the diversity of the blaOXA gene and highlighted the emergence of novel OXA carbapenemases in S. xiamenensis. Further attention to S. xiamenensis and OXA carbapenemases is recommended for the effective prevention and control of antibiotic-resistant bacteria.
Plant-Derived Quorum Sensing Inhibitors (Quercetin, Vanillin and Umbelliferon) Modulate Cecal Microbiome, Reduces Inflammation and Affect Production Efficiency in Broiler Chickens
Authors: Deryabin Dmitry G. , Kosyan Dianna B. , Inchagova Ksenia S. , Duskaev Galimzhan K.
Published: May 2023

Quorum sensing inhibitors (QSIs) are an attractive alternative to antibiotic growth promoters in farmed animal nutrition. The goal of the study was the diet supplementation of Arbor Acres chickens with quercetin (QC), vanillin (VN), and umbelliferon (UF), which are plant-derived QSIs preliminarily showing cumulative bioactivity. Chick cecal microbiomes were analyzed by 16s rRNA sequencing, inflammation status was assessed by blood sample analyses, and zootechnical data were summarized in the European Production Efficiency Factor (EPEF). When compared to the basal diet control group, a significant increase in the Bacillota:Bacteroidota ratio in the cecal microbiome was found in all experimental subgroups, with the highest expression > 10 at VN + UV supplementation. Bacterial community structure in all experimental subgroups was enriched with Lactobacillaceae genera and also changed in the abundance of some clostridial genera. Indices of richness, alpha diversity, and evenness of the chick microbiomes tended to increase after dietary supplementation. The peripheral blood leukocyte content decreased by 27.9–45.1% in all experimental subgroups, likely due to inflammatory response reduction following beneficial changes in the cecal microbiome. The EPEF calculation showed increased values in VN, QC + UF, and, especially, VN + UF subgroups because of effective feed conversion, low mortality, and broiler weight daily gain.
Changes in the Incidence of Invasive Pneumococcal Disease in Calgary, Canada, during the SARS-CoV-2 Pandemic 2020–2022
Authors: Ricketson Leah J. , Kellner James D.
Published: May 2023

We describe the impact of non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic on invasive pneumococcal disease (IPD) in Calgary. IPD declined significantly worldwide during 2020 and 2021. This may be due to the reduced transmission of and decrease in circulating viruses that often co-infect with the opportunistic pneumococcus. Pneumococcus has not been shown to frequently co-infect or cause secondary infection with SARS-CoV-2. We examined and compared incidence rates in Calgary per quarter in the pre-vaccine, post-vaccine, 2020 and 2021 (pandemic) and 2022 (late pandemic) eras. We also conducted a time series analysis from 2000–2022 allowing for change in trend at introduction of vaccines and for initiation of NPIs during the COVID-19 pandemic. Incidence declined in 2020/2021 but by the end of 2022 had begun to rapidly recover to near pre-vaccine rates. This recovery may be related to the high rates of viral activity in the winter of 2022 along with childhood vaccines being delayed during the pandemic. However, a large proportion of the IPD caused in the last quarter of 2022 was serotype 4, which has caused outbreaks in the homeless population of Calgary in the past. Further surveillance will be important to understand IPD incidence trends in the post-pandemic landscape.
Green Synthesis of Aromatic Nitrogen-Containing Heterocycles by Catalytic and Non-Traditional Activation Methods
Authors: Vlocskó R. Bernadett , Xie Guoshu , Török Béla
Published: May 2023

Recent advances in the environmentally benign synthesis of aromatic N-heterocycles are reviewed, focusing primarily on the application of catalytic methods and non-traditional activation. This account features two main parts: the preparation of single ring N-heterocycles, and their condensed analogs. Both groups include compounds with one, two and more N-atoms. Due to the large number of protocols, this account focuses on providing representative examples to feature the available methods.
Do Seropositive Wild Boars Pose a Risk for the Spread of African Swine Fever? Analysis of Field Data from Latvia and Lithuania
Authors: Oļševskis Edvīns , Masiulis Marius , Seržants Mārtiņš , Lamberga Kristīne , Šteingolde Žanete , Krivko Laura , Cvetkova Svetlana , Buitkuvienė Jūratė , Pilevičienė Simona , Zani Laura , Denzin Nicolai , Depner Klaus
Published: May 2023

In 2020, ASF occurred in wild boars throughout Latvia and Lithuania, and more than 21,500 animals were hunted and tested for the presence of the virus genome and antibodies in the framework of routine disease surveillance. The aim of our study was to re-examine hunted wild boars that tested positive for the antibodies and negative for the virus genome in the blood (n = 244) and to see if the virus genome can still be found in the bone marrow, as an indicator of virus persistence in the animal. Via this approach, we intended to answer the question of whether seropositive animals play a role in the spread of the disease. In total, 2 seropositive animals out of 244 were found to be positive for the ASF virus genome in the bone marrow. The results indicate that seropositive animals, which theoretically could also be virus shedders, can hardly be found in the field and thus do not play an epidemiological role regarding virus perpetuation, at least not in the wild boar populations we studied.