bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment and fitting of high/ultra resolution global geopotential models using GNSS/levelling over Egypt
Authors: Zayed Abdelaty Mohammed , Saber Ahmed , Hamama Mostafa , Rabah Mostafa , Zaki Ahmed
Published: November 2024

This study conducts an evaluation of the performance of seven ultra-high-degree Global Geopotential Models (GGMs) across Egypt, utilizing GNSS/leveling data as a basis for assessment. The models under investigation include SGG-UGM-2, XGM2019e_2159, SGG-UGM-1, GECO, EIGEN-6C4, EGM2008, and GGMplus. The evaluation procedure comprises three principal steps: an absolute assessment, the implementation of Residual Terrain Modelling (RTM), and the fitting of GGMs to GNSS/leveling data. Among the models assessed, GECO exhibited the highest performance in the absolute assessment, achieving a standard deviation (STD) of 0.310 m, while SGG-UGM-1 recorded the largest STD at 0.353 m. Given Egypt’s predominantly flat topography, the application of RTM yielded only modest benefits. Nonetheless, all models demonstrated significant enhancements in accuracy through the fitting process, with EIGEN-6C4 emerging as the most successful model, attaining an STD of 0.116 m in external assessment. The accuracy improvements following the fitting procedure ranged from 49 % to 63 % across all models assessed.
Black-oriented EdTech and public interest technology: a framework for accessible and ethically designed technology for K-12 students
Authors: Campbell Symone E.
Published: November 2024

This study explores the intersection of public interest technology (PIT) and K-12 Black-oriented educational technology (EdTech) platforms in addressing educational inequities and racial biases. Despite the increased adoption of EdTech in K-12 settings, it often perpetuates racial biases, marginalizing Black students. Conversely, Black-oriented educational technology has been established to counter the marginalization of Black students by centering Black culture and realities in educational content (Young, P.A. 1999. Roads to travel: a historical look at African American contributions to instructional technology. University of California, Berkeley), emphasizing principles of ethical, accessible, and impactful technology use aligned with PIT. However, research on these digital platforms is limited. This study employs multimodal critical discourse analysis to examine three K-12 Black-oriented platforms – KaiXR, Reconstruction, and TunTimo – developed by Black women, to understand how they address technology inclusion and counteract racial biases in mainstream EdTech.
Can public interest technology serve people who have disabilities?
Authors: Gran Brian , Bryden Anne M.
Published: November 2024

Public Interest Technology is an emerging paradigm, scholarly domain, and potential contributor to reducing barriers, mitigating discrimination, and promoting human rights of people who have disabilities. Employing data from individual interviews of people who have experienced spinal cord injury and their support persons, this project identifies obstacles and barriers these people experience when seeking technologies needed for rehabilitation and reintegration. This article discusses these individuals’ experiences in light of how public interest technology may be a game changer for people who have experienced spinal cord injuries.
Re-framing and enacting diversity in science education: the case of college chemistry classrooms
Authors: Picón Raúl Orduña
Published: November 2024

Scholarship about the effectiveness of programs related to promoting diversity, equity, and inclusion in college suggests that increasing the presence of marginalized students does not necessarily result in producing inclusion and a sense of belonging in science. Recruiting and retaining marginalized students in science-related fields and comparing them with students from dominant groups is assimilationist because the presence of different people does not inherently create a diverse school setting. The central goal of this viewpoint paper is to propose a holistic view of diversity at the university level. Particularly, I discuss a conceptual framework that frames diversity as a process that entails inducing, orchestrating, utilizing, valuing, and honoring the heterogeneity of ways of thinking, doing, and being of individuals to learn. To translate commitments to enact diversity in daily teaching practices, specifically in the chemistry classroom, I analyze culturally relevant pedagogy as a productive tool to encourage students and instructors to develop and leverage a robust repertoire of thoughts, practices, and identities to learn disciplinary concepts and solve problems that matter to students. To support the operationalization of diversity in science classrooms in higher education, researchers and practitioners should identify and value the coexistence of different thoughts, practices, and identities in the school to create a safe and intellectually challenging learning setting where thinking, doing, and being different is an asset toward learning.
Diagnostic challenges in pediatric Cushing’s disease associated with chronic renal failure: a report of three patients
Authors: Martínez Castillo Iratxe , Aziz Mariana , Di Palma Isabel , López Laura , Chaparro Alicia , González Ramos Javier , Mansilla Celeste , Lubienecki Fabiana , Lamas Gabriela , Rugilo Carlos Adrián , Lazzatti Juan Manuel , Ciaccio Marta , Gil Silvia
Published: November 2024

Objectives

Cushing’s disease (CD) in the context of chronic kidney disease (CKD) is very rare. CKD causes physiological hypercortisolism making the diagnosis of CD extremely difficult. To report 3 females with CKD and CD and to outline the principles that may guide the diagnosis of CD in this context.

Case presentation

P1. A 12.3-year-old patient with CKD secondary to steroid-resistant nephrotic syndrome on hemodialysis (HD) and a medical history of aseptic meningitis. She was referred due to the incidental finding of pituitary macroadenoma. P2. A patient with CKD secondary to bilateral renal hypodysplasia in conservative treatment. At age 16.4 years, she had significant weight gain, purple-red stretch marks, galactorrhea, and menstrual irregularities. P3. A 15.3-year-old patient with CKD secondary to steroid resistant nephrotic syndrome in conservative treatment was referred for weight gain, secondary amenorrhea, and hypertension. In all patients, diagnosis of CD was confirmed by clinical and biochemical findings. P1 and P3 underwent transsphenoidal surgery, and in P2, transcranial surgery resection was performed. Histopathological examination revealed a corticotroph adenoma in P1 and P2, and in P3, immunohistochemistry demonstrated ACTH predominance. All patients achieved remission. P1 and P2 developed pituitary deficiencies.

Conclusions

To the best of our knowledge, these are the first three reported cases of the diagnostic association of CD and CKD in children. In all cases, CS was clinically suspected and CD was confirmed through complementary exams. Given the current lack of clear diagnostic criteria for CD in CKD patients, a thorough clinical evaluation remains essential for guiding the diagnosis.
Was Kant a Cosmopolitan Racist?
Authors: Corradetti Claudio
Published: November 2024

Contemporary debate on Kant’s practical philosophy has focused on racial claims appearing primarily in transcripts of students’ notes taken during his lectures. But was Kant – the champion of world citizenship – really a racist? It is certainly hard to defend him from the charge of racial prejudices. However, a universally exclusivist standard of rationality such as the one he promoted leads at worst to cultural imperialism. It is more doubtful whether this amounted also to a full racist theory, as this would have implied seeing some races as inherently incapable of full rationality. Kant’s biological theory of races – the investigation of race being a theoretical rather than practical task – did not serve such a racist purpose. This article argues that Kant was ultimately interested in scientific distinctions, assuming the point of view of a naturalist researcher (Naturforscher). Accordingly, he cannot be said to be a biological racist.
Like-simile and metaphor in cooperation: from expressing similarities to expressing contrasts
Authors: Reda Ghsoon
Published: November 2024

Cognitive-oriented work on simile has developed out of attempts to pinpoint features distinguishing simile and metaphor. This development has had such consequences as 1) focusing on simile as an analogy-based process and 2) giving very little attention to the way simile and metaphor work together, treating them as independent rather than cooperating phenomena. Addressing these shortcomings, this study examines the ability of non-ironic like-simile to imply contrasts between the asserted source-target similarity and a thought or belief evoked by this similarity, giving rise to context-bound attitudinal and illocutionary implications. In cases of like-simile scaffolded by metaphors, the contrast-based process arises from the cooperation of the two phenomena in the sense that the scenario created by the like-simile rests on manipulating the conceptual metaphor(s) supporting the comparison. The analysis of these cases is placed in the Extended Conceptual Metaphor Theory (ECMT) – a contextual, multilevel theory of figurative language conceptualisation. The contrast-based process, drawn from the model of irony developed within the Lexical Constructional Model (LCM), is added to this theory as a mental-space level activity. Raykowski’s sensory schema (a generalized notion of accumulation intuitions) is also added above the image-schema level metaphors, presenting the manipulation of the scaffolding metaphors as based on the expression of this schema.
Despite Current Challenges: Lexicography has a bright future
Authors: Gouws Rufus H. , Tarp Sven
Published: November 2024

This paper responds to some of the fears regarding the future of lexicography. By referring to a number of paradigm shifts in the history of lexicography, some of the innovative endeavours currently occurring in lexicography and a number of exciting future possibilities, the paper tries to show that there is hope for a bright lexicographical future. This paper maintains the division of lexicography into two components, namely dictionography and glossography, and places special emphasis on glossography and the role of glosses. It is shown that glosses played a significant role in the early phases of lexicography and have re-emerged in the digital era where their use leads to innovative lexicographical procedures. It is argued that new challenges demand new ways of thinking about lexicography.
Oligonucleotide therapeutics for neurodegenerative diseases
Authors: Li Victor , Huang Yunlong
Published: November 2024

Recently there has been a surge in interest involving the application of oligonucleotides, including small interfering RNA (siRNA) and antisense oligonucleotides (ASOs), for the treatment of chronic diseases that have few available therapeutic options. This emerging class of drugs primarily operates by selectively suppressing target genes through antisense and/or RNA interference mechanisms. While various commercial medications exist for delivering oligonucleotides to the hepatic tissue, achieving effective delivery to extra hepatic tissues remains a formidable challenge. Here, we review recent advances in oligonucleotide technologies, including nanoparticle delivery, local administration, and 2′-O-hexadecyl (C16)-conjugation that work to extend the applicability of siRNAs and ASOs to nerve tissues. We discuss critical factors pivotal for the successful clinical translations of these modified or engineered oligonucleotides in the context of treating neurodegenerative diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis.
Exosomal microRNA-21-5p from gastric cancer cells promotes angiogenesis by targeting LEMD3 in human endothelial cells
Authors: Zhou Tianbao , Lu Ping
Published: November 2024

Objectives

The effect of exosome-derived miR-21-5p from gastric cancer (GC) on angiogenesis remains unclear. This study aims to examine the angiogenic impact of GC exosome-derived miR-21-5p.

Methods

Exosomes were isolated from GC cells and co-cultured with human umbilical vein endothelial cells (HUVECs). miR-21-5p levels in HUVECs were measured by qPCR. Flow cytometry was used to assess apoptosis, and the Cell Counting Kit-8 was used to assess cell growth. Bioinformatics analysis was used to identify the miR-21-5p target genes, which were then verified by dual-luciferase gene reporter experiments. qPCR and western blotting were employed to assess the expression of genes and proteins, respectively. Functional rescue assays were conducted to verify that miR-21-5p regulates endothelial cell function by targeting the LEM domain containing 3 (LEMD3). Additionally, cell migration was assessed using a scratch assay.

Results

Co-cultivation with GC-derived exosomes improved cell survival, decreased apoptosis, and raised miR-21-5p levels in HUVECs. Increases in vascular endothelial growth factor A (VEGFA) and the TGF-β/Smad signaling pathway were seen. It was shown that miR-21-5p targets LEMD3. The biological effects of miR-21-5p were lessened when miR-21-5p was inhibited, or LEMD3 was overexpressed.

Conclusions

By targeting LEMD3, miR-21-5p in GC cell exosomes stimulates angiogenesis by triggering the TGF-β/Smad signaling cascade and upregulating VEGFA expression. This leads to increased proliferation, survival, and migration of HUVECs, underscoring the potential of targeting this pathway in cancer therapy.
Excitation functions of proton-induced nuclear reactions on titanium
Authors: Kholil Sinthia Binte , Uddin M. Shuza , Hasan M. Mehedi , Chakraborty A. Kumer , Shariff M. Asad , Voyles Andrew S. , Spahn Ingo
Published: November 2024

Excitation functions of the natTi(p,x)43,44m,44g,46,47,48Sc and natTi(p,x)48V reactions were measured using stacked target activation from reaction thresholds up to 44.28 MeV. A wide energy range was achieved by irradiating several stacks with proton beams of energies 16.7 MeV, 27 MeV, and 44.5 MeV. Cross-section data were obtained from 15 to 25 MeV at the Lawrence Berkeley National Laboratory (LBNL) and from 14 to 44.28 MeV and 8–17 MeV at the Forschungszentrum Jülich (FZJ). Each set of measured data agrees well with each other in the overlapping energy regions. The cross sections were also calculated theoretically using the TALYS code, and the model calculations reproduced the experimental values well. Generally, the results obtained for proton-induced reactions using the global set of parameters, as expressed in the TENDL-2021 data library, are not satisfactory. Our measurements are valuable for resolving discrepancies in the existing data and providing insights into reaction mechanisms.
Advanced techniques and innovations in peripheral nerve repair: a comprehensive review for clinical and experimental reference
Authors: Zou Yuchun , Zhang Gonghang , Yang Yuchen , Huang Hankai , Li Zongxu , Chen Xiaohang , Zheng Dali , Lu You-guang , Niu Gang
Published: November 2024

Peripheral nerve injury, resulting from various physical and chemical causes, has a high incidence and significant functional impact. This injury, affecting both sensory and motor functions, can severely diminish quality of life and cause mental health issues. Consequently, it is a major focus of current research. Recent advancements in peripheral nerve repair technology, including the application of new techniques and materials, have expanded the options for nerve repair methods. A comprehensive article that combines the pathological process of peripheral nerve repair with these methods is needed to advance research in this field. This review aims to provide a comprehensive overview of various techniques for repairing peripheral nerve injuries. Beginning with the histopathology of nerve injury, it evaluates these techniques in detail to offer clinical guidance. This review summarizes the advantages and disadvantages of various peripheral nerve repair methods, including photobiological modulation therapy, suture repair, nerve graft repair, vein graft catheter repair, muscle graft repair, laser welding repair, nerve catheter repair, nerve sliding repair technology, growth factor-assisted repair, stem cell therapy, and exosome therapy. Additionally, it explores future directions in the treatment of peripheral nerve injuries, providing valuable references for experimental research and clinical treatment.
Review of structural neuroimaging and genetic findings in autism spectrum disorder – a clinical perspective
Authors: Budisteanu Magdalena , Papuc Sorina Mihaela , Erbescu Alina , Glangher Adelina , Andrei Emanuela , Rad Florina , Hinescu Mihail Eugen , Arghir Aurora
Published: November 2024

Autism spectrum disorders (ASDs) are neurodevelopmental conditions characterized by deficits in social relationships and communication and restrictive, repetitive behaviors and interests. ASDs form a heterogeneous group from a clinical and genetic perspective. Currently, ASDs diagnosis is based on the clinical observation of the individual’s behavior. The subjective nature of behavioral diagnoses, in the context of ASDs heterogeneity, contributes to significant variation in the age at ASD diagnosis. Early detection has been proved to be critical in ASDs, as early start of appropriate therapeutic interventions greatly improve the outcome for some children. Structural magnetic resonance imaging (MRI) is widely used in the diagnostic work-up of neurodevelopmental conditions, including ASDs, mostly for brain malformations detection. Recently, the focus of brain imaging shifted towards quantitative MRI parameters, aiming to identify subtle changes that may establish early detection biomarkers. ASDs have a strong genetic component; deletions and duplications of several genomic loci have been strongly associated with ASDs risk. Consequently, a multitude of neuroimaging and genetic findings emerged in ASDs in the recent years. The association of gross or subtle changes in brain morphometry and volumes with different genetic defects has the potential to bring new insights regarding normal development and pathomechanisms of various disorders affecting the brain. Still, the clinical implications of these discoveries and the impact of genetic abnormalities on brain structure and function are unclear. Here we review the literature on brain imaging correlated with the most prevalent genomic imbalances in ASD, and discuss the potential clinical impact.
Exploring the Relationship Between ESG Performance and Dividend Policy in MENAT Region: The Role of Audit Quality
Authors: Abdel Hameed Yasmin Mamdouh
Published: November 2024

Exploring the significance of ESG performance is especially crucial in the Middle East, North Africa, and Turkey (MENAT) area, where economic and cultural environments differ. The study aims to empirically assess the relationship between firms’ dividend policy and ESG performance in MENAT, along with the moderating effect of audit quality. The research is novel in exploring this link in the MENAT region. The study uses dividend yield (DY) as the dependent variable and yearly ESG combined score from the Eikon Refinitiv database, which range from 0 to 100 as the primary independent variable, with control variables as retained earnings, profitability, firm size, and financial leverage. The results indicate a significant negative relationship between ESG scores and dividend yields, suggesting a trade-off between prioritizing ESG factors and short-term returns. The moderating effect of audit quality on the ESG-dividend policy connection is insignificant. Additionally, retained earnings and corporate size have positive effects on dividend policy, while financial leverage has a negative impact. Profitability shows an insignificant effect on dividend yield.
A genealogy of poetry
Authors: Young Jake
Published: November 2024

Poetry does not have a history; it has many histories. By tracing the history of poetry in the West, in conjunction with genre studies and research on concept formation, it is evident that the genre “poetry” is contingent on the various rhetorical situations of its production. Such an approach reveals that the concept “poetry,” like all concepts, is always in flux. Yet, despite the fact that “poetry” means different things to different people in different times and places, studies of oral poetry have yielded insights into traits that might be considered universal to poetry, such as its performativity and categorization as ritual language. Other common aspects include the use of parallelism, analogy and metaphor, musicality, and how poems function as metapragmatic symbols that reflect the values of their cultural production. This functionalist approach to poetry reveals that the evolution of poetry is at once historically contingent and culturally universal, and recognizes that poetry’s multiplicity and continual becoming operate with the primary goals of generating and sharing culturally relative meaning.
A semiotic lifeworld. Semiotics and phenomenology: Peirce, Husserl, Heidegger, Deleuze, and Merleau-Ponty
Authors: Paolucci Claudio
Published: November 2024

If we think of cognition and experience from the enactivist idea of a structural coupling between organism and environment, we see that this environment is first and foremost a semiotic environment, crowded with objects, norms, habits, institutions, and artefacts that shape our minds and represent the background of our perception of the world. This semiotic environment, which goes far beyond the opposition between nature and culture, (See Paolucci 2021. Cognitive semiotics: Integrating signs, minds, meaning, and cognition. Berlin: Springer: ch. 1.) is a semiotic lifeworld that is important to compare with the classic idea of lifeworld coming from phenomenology. In this paper, (i) we will first start with a comparison of the semiotic Lebenswelt and the phenomenological Lebenswelt; (ii) we will follow the construction of the semiotic lifeworld coming from Peirce’s Anti-Cartesian essays; (iii) we will make a deep comparison between the phenomenology coming from Peirce (phaneroscopy) and the phenomenology coming from Husserl, Heidegger, and Merleau-Ponty; (iv) we will show how these very same principles also ground structuralism; (v) we will show how this new semiotic lifeworld grounded on phaneroscopy is neither pre-logical nor pre-categorial. Rather, it is founded on the primacy of “telling” over “showing,” and on the primacy of discourse over perception.
A footless stroll through Italian stress
Authors: Faust Noam , Ulfsbjorninn Shanti
Published: November 2024

Despite the fact that Italian has been studied intensely for many years, the intricate relationship between its syllable structure and its metrical facts (weight and stress assignment) still poses a very significant formal challenge to previously published theoretical accounts. In this paper, we provide a novel account of Italian stress within the framework of Strict CV Metrics. We show that this approach most accurately captures the empirical data of the language, while providing a formally simple analysis which does not require feet, binary or ternary. The analysis is computationally simple and derives the ‘three syllable’ window effect without arbitrarily stipulating the foot-size of the language or overgenerating forms.
Blending Borders and Sparking Change
Authors: Macuglia Daniele
Published: November 2024

Between the mid-1970s and mid-1980s, molecular simulations emerged as a transformative force within materials science. Sidney Yip’s early contributions at the Massachusetts Institute of Technology, alongside his involvement in the 1985 International School of Physics “Enrico Fermi” in Varenna, Italy, catalyzed the convergence of traditional methods with computational techniques and helped drive a redefinition of the discipline’s epistemic and methodological boundaries. This article argues that Yip’s biography and professional trajectory as a Chinese-born engineer and scientist in the United States during the Cold War facilitated the acceptance and advancement of molecular simulations within materials research. His work also attracted the interest of leaders from established fields, such as condensed matter physics and chemical physics, to explore the potential applications of these techniques in materials science. In examining his journey, this study illuminates the dual processes of cultural assimilation and hybridity, and highlights Yip’s boundary work that promoted the integration of diverse epistemic traditions and heterogeneous communities. The analysis traces the epistemological transformations, methodological shifts, and the institutional and disciplinary dynamics that fostered the incorporation of molecular simulations into materials science. This examination foregrounds the co-construction of scientific knowledge and technological practice through Yip’s boundary work, and offers an assessment of his contributions within the broader sociotechnical networks that shaped the field. Recognizing the paucity of existing historiography on the subject, this article aims to establish a framework based on primary sources that can serve as a foundation for future scholarly inquiry.
Accuracy of Screening Tests for the Diagnosis of Urinary Tract Infections in Young Children
Authors: Shaikh Nader , Campbell Elizabeth A. , Curry Calise , Mickles Caitlin , Cole Elisabeth B. , Liu Hui , Lee Matthew C. , Conway Isabella O. , Mueller Grace D. , Gibeau Asumi , Brady Patrick W. , Rasmussen Jayne , Kohlhepp Mark , Qureini Heba , Moxey-Mims Marva , Williams Whitney , Davis-Rodriguez Stephanie
Published: November 2024

BACKGROUND

The objective of this study was to compare the accuracy of available tests for pyuria, including newer automated tests, and to examine the implications of requiring them for the diagnosis of urinary tract infections (UTIs).

METHODS

We included children between 1 and 36 months of age undergoing bladder catheterization for suspected UTIs who presented to 1 of 3 pediatric centers. Using a positive urine culture result as the reference standard, we compared the sensitivity of 5 modalities for assessing pyuria at the cutoffs most often used clinically for detecting children with a positive culture result: leukocyte esterase on a dipstick, white blood cell (WBC) count on manual microscopy with and without using a hemocytometer, automated WBC enumeration using flow cytometry, and automated WBC enumeration using digital imaging with particle recognition.

RESULTS

A total of 4188 children were included. Among febrile children, the sensitivity of the 2 most widely available modalities, the leukocyte esterase test and WBC enumeration using digital imaging, had sensitivity values of 84% (95% confidence interval, 0.80–0.87) and 75% (95% confidence interval, 0.66–0.83), respectively.

CONCLUSIONS

Our findings suggest that for febrile children <36 months of age undergoing bladder catheterization for suspected UTI, pyuria will be absent in ∼20% of children who are eventually shown to have pure growth of a pathogen on a culture. This raises questions about the appropriateness of requiring pyuria for the diagnosis of UTIs.
Therapeutic potential of simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation
Authors: Luo Song , Wang Xiaorui , Ma Bo , Liu Dongliang , Li Li , Wang Lijin , Ding Ning , Zou Liangyu , Wang Jie , Pan Jialin , Sang Daoqian , Zhou Huadong , Qu Hongdang , Lu Yi , Yang Lijuan
Published: November 2024

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective death of motor neurons in the spinal cord, brainstem, and motor cortex. This study investigates the effects of simvastatin on the G93A-copper/zinc superoxide dismutase (G93ASOD1) transgenic mouse model of ALS. The experiment included three groups: C57BL/6 wild-type mice, C57BL/6J SOD1G93A mice treated with PBS (SOD1G93A + PBS), and C57BL/6J SOD1G93A mice treated with simvastatin (SOD1G93A + simvastatin). The primary endpoints were survival rates, body weight changes, performance in pole climbing and suspension tests, and neurological deficit scores. Pathological changes were assessed using hematoxylin and eosin staining, transmission electron microscopy, Nissl staining, and Masson staining. Proteomic and metabolomic analyses were performed to identify differentially expressed proteins (DEPs) and metabolites. Quantitative real-time polymerase chain reaction and western blotting were used to measure gene expression. Although there were no significant differences in survival rates, body weight, pole climbing, and suspension test performance, or neurological deficit scores between the SOD1G93A + simvastatin and SOD1G93A + PBS groups, simvastatin treatment improved axonal organization within the spinal cord, increased the number of neurons, and reduced cytoplasmic swelling and gastrocnemius fibrosis. A total of 47 DEPs and 13 differential metabolites were identified between the SOD1G93A + PBS and SOD1G93A + simvastatin groups. Notably, the expression levels of Apoa4 and Alb were elevated in the SOD1G93A + simvastatin group compared to the SOD1G93A + PBS group. Our results suggest that simvastatin may have potential therapeutic effects in ALS, likely involving the modulation of Apoa4 and Alb expression.
Data Security and Privacy Protection in Health Information Management: Challenges and Solutions
Authors: Mu Tiantian , Xu Yang
Published: November 2024

This study provides a comprehensive review of the current trends and future challenges in the field of Health Information Management (HIM). With advancements in technologies such as big data, cloud computing, and artificial intelligence, the global health information management market is projected to experience rapid growth. Research indicates that HIM not only enhances the efficiency and quality of healthcare services but also contributes to improvements in public health and medical services worldwide. However, despite these significant advancements, the field continues to face numerous challenges, including patient data privacy and security, optimization of user interface design, and the demand for personalized information services. Therefore, this study focuses on these core issues and reviews related research in the field of health information management. It analyzes the advantages and limitations of various methods and technologies and predicts future development trends. Consequently, interdisciplinary collaboration, technological innovation, and personalized services are expected to be key directions for future development. This study not only reviews current trends and challenges in health information management but also provides strategic insights and innovative approaches that contribute to advancing the field, setting the stage for future research and practical improvements in data security and privacy.
Whole-cell Patch-Clamp Recordings from Striatal Cholinergic Interneurons in ex vivoMouse Brain Slices v2
Authors: Stedehouder Jeff , J Cragg Stephanie
Published: November 2024

This protocol describes the steps to perform whole-cell patch-clamp recordings of striatal cholinergic interneurons (ChIs) previously labelled with the fluorophore mCherry from acute, ex vivo mouse brain slices.
SHARE-seq protocol v2.2 v3
Authors: Hall Amelia , Torrecampo Gwyneth , Ham Alexandra , White Cassandra , Barreto Corona Guillermo , Mattei Eugenio , B Epstein Charles
Published: November 2024

An updated version of the protocol SHARE-seq, as used by the Epigenomics Platform and Gene Regulation Observatory at the Broad Institute in the service of data production for the IGVF project. Link to the original paper and protocol here: https://www.sciencedirect.com/science/article/pii/S0092867420312538
TIREseq -Turbocapture Integrated RNA Expression Sequencing v1
Authors: V Brown Daniel
Published: November 2024

To streamline sample processing we developed a novel protocol integrating RNA purification with library preparation, Turbocapture Integrated RNA Expression Sequencing (TIREseq) This new protocol exhibits a significantly accelerated workflow, higher sequencing efficiency and lower molecular contamination.
Industrial Control as a Service
Authors: Vogt Lucas , Honold Fabian , Schmid Tobias , Punzenberger Lukas , Greising Samuel , Waltl Josef , Beckhoff Laurids , Auer Marcel , Jilg Michael , Maurer Frank , Barth Mike , Urbas Leon , Blumer Wolfgang
Published: November 2024

Industrial Control as a Service (ICaaS) hat das Potenzial, die IT- und die OT-Welt näher zusammenzubringen. Es verspricht eine kürzere Time-to-Market, weniger Komplexität für Anlagenbesitzer/-betreiber sowie die einfache Integration fortschrittlicher Technologien wie KI. Um diese Behauptungen zu überprüfen, werden in diesem Artikel mehrere Proof-of-Concept-Anwendungsfälle für verschiedene ICaaS-Aspekte vorgestellt und diskutiert. Darüber hinaus werden Möglichkeiten zur   Weiterentwicklung des Konzepts skizziert.
Desafios e perspectivas na pesquisa biomédica com dados na União Europeia na Era Digital
Authors: Sarrión-Esteve Joaquín
Published: November 2024

The Digital Age in which we live requires the rethinking of current legal paradigms, both from the point of view of regulation and governance, and this particularly affects data, and scientific research with data. This work attempts to provide an overview of the challenges and opportunities that arise in this area, seeking a multidisciplinary legal research methodology adapted to the emerging (European) law of science and technology. It concludes the need to work so that in its development, both regulation and governance follow a series of ethical and legal principles that allow the guarantee of the rights and freedoms of people.
Submission: 10/01/24| Review: 10/23/24| Approval: 10/23/24
A formação em Direito Sanitário: experiências acadêmicas no Brasil e Espanha
Authors: Alves Sandra Mara Campos , Delduque Maria Célia , Bombillar Sáenz Francisco Miguel , Sarrión Esteve Joaquín
Published: November 2024

Objective: To understand the training experiences in Health Law adopted in Brazil and Spain and reflect on their challenges, successes, and/or limitations, especially because it is a topic that has been little explored in academic-scientific literature. Methodology: The experience report method was adopted, using the storytelling technique, which allowed for the narrative of the course experiences in Brazil and Spain from the perspective and experience of their respective coordinators, without the inclusion of students or faculty in the narratives. Results: The study presented reports of experiences of a lato sensu course already consolidated in Brazil in the face-to-face modality and, to fill the educational gaps in the field of Health Law, it is also offered in the distance learning modality. The Spanish experiences, on the other hand, presented a traditional model of a stricto sensu course, with an academic and professional focus, offered to professionals in Law and Health, along with a modular distance learning option that allowed the acquisition of corresponding titles based on obtained credits. Conclusion: The consolidation of health as a right must assume a commitment to expanding the capacity of professionals in Law and Health to defend health interests. There is no doubt that training in Health Law is imperative for any professional working, directly or indirectly, with health-related issues.
Submission: 10/23/24 | Approval: 10/23/24
Electrophysical characteristics of hafnium oxide and barium strontium titanate ferroelectric films
Authors:   Kotel'nikov Institute of Radioengineering and Electronics of RAS, Fryazino branch, Afanasyev Mikhail S. , Belorusov Dmitry A. ,   Kotel'nikov Institute of Radioengineering and Electronics of RAS, Fryazino branch, Kiselev Dmitry A. ,   Kotel'nikov Institute of Radioengineering and Electronics of RAS, Fryazino branch, Luzanov Valery A. ,   Kotel'nikov Institute of Radioengineering and Electronics of RAS, Fryazino branch, Chucheva Galina V. ,   Kotel'nikov Institute of Radioengineering and Electronics of RAS, Fryazino branch
Published: November 2024

Electrophysical properties of hafnium oxide (HfO2) and barium strontium titanate of the composition (BST) thin films of various thicknesses from 20 nm to 250 nm are studied. Capacitance-voltage characteristics of Ni/HfO2/Si and Ni/BST/Si structures have been measured. The hysteresis loops width values are obtained depending on the films thickness. It is shown, that as the films thickness increases, the surface roughness and grain size increase. Calculated the exponential growth index values were β = 1.4 for HfO2, and β = 0.5 for BST films. Based on the local hysteresis loops results obtained in the polarization switching spectroscopy mode, coercive field values for studied films of various thicknesses were calculated, and «scaling» effect was found. It has been found that BST films are more ferroelectric «soft» material compared to HfO2 films at the same thicknesses.
Metaverse and virtual worlds of science
Authors:   RUDN University, Sheka Elena F.
Published: November 2024

Information is presented on the emergence of a new meaning for the existence of human communities, which could be characterized by the word "hyperrealization". Virtual worlds of digital twins, digital ecosystems, quasi-metaverses, and, finally, the metaverse – this is the path that everything existing in the world, including science, must take.
In Memory of Sergey P. Gubin
Authors:   Kotel’nikov Institut of Radioengineering and Electronics of RAS, Grachev Vladimir I.
Published: November 2024

Information is presented about the deceased Sergey Pavlovich Gubin, Doctor of Chemical Sciences, Professor, head of the Laboratory of Nanomaterial Chemistry at the N.S. Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, laureat of the USSR State Prize, Honored Scientist of Russia, full member of the Russian Academy of Natural Sciences, a well-known specialist in the fields of solid state chemistry, nanosystems and nanotechnology. The main biographical data are given: studies at the M.V. Lomonosov Moscow State University (Faculty of Chemistry), postgraduate studies and work at INEOS AN USSR, defense of PhD and doctoral (chemical sciences) dissertations, authorship of more than 600 scientific papers in scientific journals, 5 books and about 40 patents, graduation of 6 doctors and more than 30 candidates of sciences, participation in Russian and international conferences and seminars, editorship in scientific journals. Founding and directorship at the Krasnoyarsk Institute of Chemistry and Chemical Technology of the USSR Academy of Sciences, directorship at the Novosibirsk Institute of Chemistry and Chemical Technology of the USSR Academy of Sciences (Siberian Branch). Work at the N.S. Kurnakov IGIC of RAS, creation and management of the country's first laboratory of nanomaterials chemistry, creation and development of graphenics in the country, professorship at M.V. Lomonosov Moscow State University and at the Faculty of Physics of M.V. Lomonosov Moscow State University, membership in various Russian and international scientific societies and expert councils.
Magnetic resonance imaging in diagnosis of serous adenocarcinoma of fallopian tubes: a case report
Authors: Mynko Oleg I. , Gonchar Anna P. , Nechaev Valentin A. , Kulikova Evgeniya A. , Yudin Andrey L. , Yumatova Elena A.
Published: November 2024

Serous adenocarcinoma of fallopian tubes is an extremely rare and difficult-to-diagnose type of cancer of the female reproductive system. This condition is often asymptomatic or has a non-specific clinical presentation including serosanguineous vaginal discharge and colic-like pain in the lower abdomen and pelvis. These symptoms are reported in the literature as the Latzko’s triad and are considered pathognomonic for tubal cancer, but their combination is observed in less than 15% of patients. The low incidence and lack of the pathognomonic clinical presentation lead to many diagnostic errors or detection of advanced disease, which significantly worsens the patient’s prognosis. An accurate surgical diagnosis is made in only 4% of cases. This case report describes serous adenocarcinoma of fallopian tubes with all signs of the Latzko’s triad and MRI suggestive of serous adenocarcinoma of fallopian tubes at a preoperative stage.
Dynamics of markers of oxidative stress during the complex use of therapeutic physical factors in patients with true eczema associated with metabolic syndrome
Authors: Arutyunyan Emma E. , Mikhailova Anna A. , Nagornev Sergey N.
Published: November 2024

BACKGROUND: Among various pathological conditions associated with true eczema, metabolic syndrome occupies a special place, the high social significance of which is determined by its dominant influence on the main demographic indicators — life expectancy and mortality of the population.
AIM: Assessment of the dynamics of parameters of pro- and antioxidant systems in patients with true eczema in combination with metabolic syndrome during the course application of broadband medium-wave phototherapy, mesodiencephalic modulation and their combination.
MATERIALS AND METHODS: A prospective, controlled, comparative, randomized study was performed involving 115 patients with true eczema combined with metabolic syndrome, who were divided into 4 groups using simple randomization. The first group (control) received only basic drug therapy. In the second (comparison 1), third (comparison 2), and fourth (main) groups, patients additionally underwent courses of broadband medium-wave phototherapy, mesodiencephalic modulation, and their combination, respectively. The results of the course application of physiofactors were assessed by the dynamics of pro- and antioxidant system indices before and after the end of therapy.
RESULTS: When comparing the main markers of oxidative stress between the group of healthy people and patients with true eczema in combination with metabolic syndrome, a pronounced imbalance in the "prooxidants-antioxidants" system was established, which indicates the development of oxidative stress. Conducting complex therapy had a corrective effect on the parameters of the lipid peroxidation process. More pronounced shifts in lipid peroxide metabolism indicators were revealed in the groups with the additional use of physiotherapeutic factors. The maximum corrective effect in relation to oxidative stress was established in the group with the complex use of physiofactors. An integrative assessment of the dynamics of oxidative stress markers using the antioxidant protection coefficient confirmed the results obtained.
CONCLUSION: The use of therapeutic physical factors in the therapy of true eczema and metabolic syndrome is largely based on their ability to act as redox regulators of intracellular processes, exhibiting a stress-limiting effect and restoring oxidation-reduction homeostasis. The most promising in this regard are broadband medium-wave phototherapy and mesodiencephalic modulation.
A Preliminary Evaluation of Biogas Generation from Cattle Manure at Caño Fistola Farm of the Colombian Caribbean
Authors: Moreno Rios Andrea liliana , Yepes Maldonado Régulo Antonio
Published: November 2024

This research addresses the evaluation of the potential for biogas production from bovine manure on a rural property located in Ponedera, Atlántico, Colombia. Initially, the materials necessary for constructing the biodigester and the amounts of substrate necessary to experiment were defined. The biodigester was built and the experiment was implemented. Biogas measurements were carried out for 10 days after 20 days of filling the biodigester. The estimation of biogas's theoretical and experimental production was carried out, considering different parameters and methodologies. The results showed that the biogas production potential of the Caño Fistola farm (150 head of empty cattle) was 3,685 m³ per year, equivalent to 17,319.5 kWh of energy per year and 1,695.1 kg of LPG. To provide the minimum consumption of the farm (approximately 200 kWh per month, 2,400 kWh per year) only implementing 3 biodigesters and 23 heads of empty cattle would be sufficient. These results highlight the potential of the application of low-cost batch anaerobic biodigesters in obtaining biogas to achieve energy self-sufficiency in rural properties. In addition, they contribute to the Sustainable Development Goals (SDG 7) Affordable and Clean Energy, and (SDG 13) Climate Action
Investigating the influence of monetary policy on the balance sheet performance of commercial banks
Authors: Kalua Denis , Lipunga Andrew Munthopa , Banda Fredrick
Published: November 2024

Research aims: The study investigates the influence of monetary policy on the balance sheet performance of commercial banks in Malawi.Design/Methodology/Approach: The study employed an explanatory research design using time series data obtained from financial reports of commercial banks and economic reports published by the Reserve Bank of Malawi from 2012 to 2022. Regression analyses were conducted to establish the influence of monetary policy on balance sheet performance (loan and overdraft growth).Research findings: The results suggest that the monetary policy instruments, namely, the liquidity reserve requirement (LRR), Lombard rate, policy rate, and open market operations, have insignificant influence on the loan and overdraft growth in commercial banks in Malawi.Theoretical contribution/Originality: This implies that these monetary policy tools are not the exterior determinants of the balance sheet performance of commercial banks in Malawi.Research limitation: The study used a single measure of the balance sheet performance of commercial banks.
Carbon emissions disclosure: an overview of research in Indonesia
Authors: Nilasakti Afifah Oki , Aryani Y Anni , Setiawan Doddy
Published: November 2024

Research aims: This research aims to find out the research’s development of carbon emissions disclosure topic in the Indonesia context.Design/Methodology/Approach: The method employed was charting the fields by Hesford et al. (2006) on some articles indexed by Sinta 2 and 3, as well as Scopus with research based in Indonesia. The articles were selected by criteria, obtaining 60 articles for further analysis.Research findings: The literature study’s results showcase that the carbon emission disclosure research trend in Indonesia has increased in the last five years. This trend was reviewed deeply through further discussions in terms of its factors influencing and consequences, theories and samples used. The major factors influencing carbon emission disclosure are profitability, firm size, and leverage. Moreover, carbon emission disclosure also affects firm value. Theoretical contribution/Originality: This study provides knowledge regarding existing carbon emission disclosures and opportunities for further research agenda, especially on empirical research.