bluuebunny/crossref_metadata_2025 huggingface dataset:
Fuzzy modeling of biometric variables development of tomato crop under irrigation and water salinity effects
Authors: Gabriel Filho Luís Roberto Almeida , Viais Neto Daniel dos Santos , Putti Fernando Ferrari , Bordin Deyver , Silva Junior Josué Ferreira , Cremasco Camila Pires
Published: February 2024

Tomato is a demanding crop in terms of handling, mainly because irrigation has a strong influence on fruit production and quality. Salinity changes the absorption, transport, assimilation, and distribution of nutrients in the plant. In general, such effects are analyzed using statistical tests. However, fuzzy models allow simulations between points that are not verified in agricultural experimentation. Currently, systems with artificial intelligence have excelled in the field of applied sciences, particularly fuzzy systems applied to mathematical modeling. The objective of this research was to use fuzzy modeling to analyze the biometric variables during the development of hybrid tomatoes under two different conditions: the first concerning different water tensions in the soil and the second concerning different salinity doses in irrigation. To this end, two models were developed based on an experiment carried out at São Paulo State University (UNESP), School of Agriculture, Botucatu, São Paulo State, Brazil. Both models sought to estimate the values of biometric variables of the tomato crop. Thus, two models were developed: Model 1 regarded water tensions and days after sowing (DAS), while Model 2 featured salinity and DAS. Fuzzy models provided results that verified the effects of irrigation and salinity layers. Two Fuzzy Rule-Based Systems (FRBS), an input processor with two variables, a set of linguistic rules defined from statistical procedures with percentiles, the Mamdani fuzzy inference method, and the center of gravity method to defuzzification were elaborated for this purpose. The range between −25 and −10 kPa (for Model 1) and between 0.08 and 3 dS m−1 (for Model 2) provided the development within the ideal parameters for the complete development of the plant cycle. The use of fuzzy logic has shown effectiveness in evaluating the development of tomato crops, thus showing potential for use in agricultural sciences. Moreover, the created fuzzy models showed the same characteristics of the experiment, allowing their use as an automatic technique to estimate ideal parameters for the complete development of the plant cycle. The development of applications (software) that provide the results generated by the artificial intelligence models of the present study is the aim of future research.
Substrates and containers influence the growth of Campomanesia phaea (O. Berg. Landrum) seedlings, an endangered Atlantic Rainforest species
Authors: Santoro Marcelo Brossi , Gomes Juliana Aparecida Souza , Brogio Bruna do Amaral , Jacomino Angelo Pedro , Silva Simone Rodrigues da
Published: February 2024

Native to the Brazilian Atlantic Rainforest, cambuci fruits can be consumed either in natura or in the processed form, and cambuci trees can be used to recover degraded areas. However, studies regarding cambuci germination and seedling development are scarce. The main aim of this study was to understand how different substrates and containers influence the growth of cambuci seedlings. To this end, two experiments were conducted: five different substrates were tested in the first experiment, and based on the multivariate analysis of the first experiment, the effect of combination of the best-performing substrates and three commonly employed plant growth containers on seedling development was investigated. Overall, good quality cambuci seedlings were obtained when they were grown in the commercial pine bark substrate and peat and perlite mixture in a 260 cm3 container.
Ingles Performance and physiological response of juvenile tambaqui (Colossoma Macropomum, Curvier 1818) feeding with pequi oil (Caryocar Brasiliense, Camb)
Authors: Rocha Alysson Soares da , Navarro Rodrigo Diana
Published: February 2024

The aim of the study was to evaluate the performance and physiological responses of juvenile tambaqui (Colossoma macropomum) fed diets containing pequi oil (Caryocar brasiliense, Camb). A total of 240 juveniles were observed, with an average weight of 17.91±4.87g, distributed in 20 boxes with a capacity of 500 liters each, in a completely randomized design with five treatments and four replications, containing 12 fish per replication. Five isoprotein diets (41% of crude protein) containing increasing levels of pequi oil (0.5, 1.5, 2.0, 3.8 and 5.5%) were assessed. The animals were kept in a water recirculation system, equipped with a filter, forced aeration, and a 12-hour photoperiod. To evaluate the performance, survival rate, weight gain, feed conversion, specific growth rate, protein efficiency rate, hepatosomatic index, and digestive-somatic index were analyzed. For physiological responses, hematological parameters and indexes, and differential leukocyte counts were determined. The concentration of serum protein, albumin, and globulin was also determined at the end of a 60-day period. There was no effect of the inclusion of pequi oil on weight gain, feed conversion, and protein efficiency rate (p ˃ 0.05). The specific growth rate was significantly different (p ˂ 0.05) with the reduction of treatments. An increase in the hepatosomatic index was observed in the treatments, with significant differences (p ˂ 0.05) and a linear increase, resulting in evidence of a lack of essential fatty acids. Hematocrit values showed no differences, but discrepancies were observed (p ˂ 0.05) for the number of erythrocytes, which, however, remained within the reference values for the species. The hematometric ratios also showed differences between treatments (p ˂ 0.05), remaining within the reference values, not characterizing an anemic condition in the animals. The increase in serum protein levels suggests that pequi oil starts to act as an immunostimulant. However, the use of pequi oil in juvenile tambaqui was not able to guarantee an efficient growth rate.
Ingestive behavior, volatile fatty acids, blood biochemical and hormonal variables of dairy goats supplemented with glycerin
Authors: Freire Luís Flávio da Silva , Cruz George Rodrigo Beltrão da , Ribeiro Neila Lidiany , Costa Roberto Germano , Silva Gislaine Ferreira , Salviano Giullyann de Oliveira , Chiodi John Edson , Leite José Aparecido de Oliveira , Matos Júnior Joab Jorge Leite de , Leite Jackson Rômulo de Sousa
Published: February 2024

The objective of this research was to determine the ingestive behavior, volatile fatty acids, and blood biochemical and hormonal variables of goats consuming a diet with 15% glycerin. Feed efficiency (FE) and rumination (ER) of dry matter intake (DMI) and neutral detergent fiber (NDFI) of dairy goats supplemented with glycerin (0 and 15%) were not influenced by treatments (p > 0.05). The specific activities of defecation, urination and drinking had a significant effect (p < 0.05) in relation to the treatments with glycerin in the diet of dairy goats. The occasional activities (defecation, urinating and drinking water) decreased with the addition of 15% of glycerin in the goats’ diet. Lactic acid had a significant effect (p < 0.001) with the addition of 15% glycerin. Diets for dairy goats with 15% glycerin did not change the consumption of dry material, neutral detergent fiber, nor did they change the ingestive behavior of these animals. The levels of globulin, protein, albumin/globulin, glucose, cholesterol, urea, triglycerides, cortisol, and T4 variables were significantly influenced (p < 0.05) by the addition of glycerin in the diet.
Fermentation quality and nutritional value of marandu grass silage with dehydrated banana peel
Authors: Marques Orlando Filipe Costa , Sales Eleuza Clarete Junqueira de , Monção Flávio Pinto , Silva Ariadne Freitas , Rigueira João Paulo Sampaio , Pires Daniel Ananias de Assis , Rufino Leidy Darmony de Almeida , Valentim Jean Kaique
Published: February 2024

The objective of this study was to evaluate the fermentation profile and nutritional value of Marandu grass silage (Urochloa brizantha (Hoschst.Ex. A. Rich) R. D. Webster cv. Marandu Syn. Brachiaria brizantha (Hochst. Ex A. Rich) Stapf cv. Marandu} with different levels of inclusion of dehydrated banana peel. The experiment was conducted in a completely randomized design with marandu grass with five levels of dehydrated banana peel (0, 10, 20, 30 and 40% of natural matter) with eight replicates. The data collected were submitted to analysis of variance and, when the "F" test was significant, the inclusion levels of the pre-dried banana peel were analyzed utilizing orthogonal polynomials and linear and quadratic regression models. The mean values of N-NH3 were adjusted to the linear regression model (p < 0.01), while the pH values had the lowest value of 4.3 with the inclusion of 15% of banana peel. The mean values of the gas loss (PG, P = 0.01) and the dry matter recovery (RMS; P = 0.01) were adjusted to the quadratic regression model, with a minimum point of 16.15% for losses and 21% as the maximum point for dry matter recovery. The rate of degradation potential degradability of the dry matter (SD; P = 0.74) did not vary with the inclusion of the banana peel. The potential degradability standardized at 2, 5 and 8% was adjusted to the regressive linear regression model (p < 0.01), and for each percentage point of inclusion of the banana peel, there was a reduction of 0.23, 0.14 and 0.10%, respectively. The inclusion of 10 to 20% dehydrated banana peel in the marandu grass silage improves the fermentation profile and the nutritional value of the silage
Bone regeneration in critical size calvarial defects using synthetic hydroxyapatite and mineralized bovine tendon base materials: a micro-computed tomography analysis
Authors: Amaral Maurício Bordini do , Viana Rommel Bezerra , Viana Katúcia Bezerra , Diagone Cristina Aparecida , Denis Aline Bassi , Plepis Ana Maria de Guzzi
Published: February 2024

This investigation used materials based on synthetic hydroxyapatite and mineralized bovine tendon as a framework for bone regeneration and evaluated the osteoconductivity of these materials in the calvaria of Wistar rats in comparison to Bio-Oss/Geistlich. Micro-computed tomography (µ-CT) analyses were performed non-invasively using three-dimensional image reconstruction to evaluate new bone formation; in addition, conventional histological analysis was used. The µ-CT results showed that Bio-Oss resulted in higher volume, density and bone percentage than the other materials. Based on the three-dimensional reconstructed images, the lowest resorption rates were observed in the Bio-Oss group, and the materials remained in larger quantities inside the defect at thirty days. In the synthetic hydroxyapatite group, intense resorption of the material and slight bone formation on the defect margins were noted, yielding an irregular edge. The mineralized bovine tendon group showed discrete new bone formation, and the material was fully resorbed. The Bio-Oss and synthetic hydroxyapatite groups yielded similar amounts of blood vessels and osteoblastic cells, and these were higher than the amounts found in the mineralized bovine tendon group. Synthetic hydroxyapatite was present within the defect and exhibited osteoconductive properties that were similar to the commercial brand, Bio-Oss. Mineralized bovine tendon did not exhibit good osteoconductivity and is contraindicated for maintaining bone space. Moreover, µ-CT yielded lower specificity; that is, µ-CT was not able to distinguish bone tissue from Bio-Oss, although it exhibited high sensitivity. Based on these results, it appears that synthetic hydroxyapatite has great potential for use in filling bone defects, unlike mineralized bovine tendon
Study on Adsorption of Diesel Molecules on MoS2 and NiMoS Catalysts
Authors: Qu Ya Kun , Zhao Xiao Guang , Wang Li Xin , Li Hui Feng
Published: February 2024

For deep insight into complex reaction system of diesel hydrotreating, the monolayer adsorption and competitive adsorption of typical reactant molecules (phenanthrene, naphthalene, acridine, quinoline, dibenzothiophene, 4,6-dimethyldibenzothiophene and H2) on MoS2 and NiMoS catalyst models with different structures were investigated. The basal plane is discovered to be the best physical adsorption position for all molecules in MoS2 series catalysts. Following saturation of the basal plane, reactant molecules will be adsorbed at Mo edge first, and Mo edge is more prone to bimolecular or multimolecular adsorption than S-edge, implying that Mo edge active sites play an important role in diesel hydrotreating. Naphthalene has a higher adsorption capacity in the partial pressure system that simulates the actual reaction atmosphere, and it is the most likely reactant molecule to predominately occupy active sites, but 4,6-dimethyl dibenzothiophene still exhibits good competition adsorption performance due to its high adsorption capacity and heat release. Interestingly, after phenanthrene adsorption, the secondary adsorption of hydrogen decreases in all of the catalyst models studied, indicating that phenanthrene is one of the most important molecules influencing hydrogen adsorption. Furthermore, the secondary adsorption of hydrogen after phenanthrene adsorption decreased the most on Tri-S50 catalyst. It shed light on that the activity and stability of Tri-S50 catalyst was most likely to decrease during diesel hydrotreating because of the notable inhibition on adsorption of hydrogen molecules brought by phenanthrene adsorption. It presents a theoretical basis for the design and development of highly efficient diesel hydrotreating catalysts.
The Effect of Three Factors Interaction on the Size Distribution of White Sugar Crystals in the Batch Vacuum Pan
Authors: Halomoan Halomoan , Nurkhamidah Siti , Altway Ali
Published: February 2024

Crystal size disribution is a parameter used to indicate the quality of sugar crystals obtained from the crystallization process. The better the crystal size distribution, the better the quality of the sugar crystals produced. The good quality of sugar crystals has an impact on the easier separation process that will occur in the centrifugal machine and can reduce sugar loss both in the centrifugal machine and in the sugar grader. The purpose of this study is to determine the effect of the number of sugar seeds, the quality of the mother liquor and the length of time used in the crystallization process on the quality of white sugar crystals produced in the Batch Vacuum Pan and to obtain the best interaction from several levels used for each factor, which can be used as a reference for producing sugar products that have crystal size distribution values according to the desired standard. Each treatment was carried out twice. Observations were made on material characteristics (brix, pol, and purity) and product sugar characteristics (average crystal size and coefficient of variation of crystal size). Measurement of the characteristics of sugar using a sieving (granulometer) which is then calculated using the ICUMSA GS2-37 method. The influence of factor’s main effect and interaction were analyzed using analysis of variance at the level of p value ≤ 0.05. Further tests for each factor’s main effect and interaction with p values ≤ 0.05 were carried out using the Duncan Multiple Range Test (DMRT). The best distribution of sugar crystal size was obtained from the interaction of sugar seed factors with levels of 3 m3, 5 m3, or 10 m3 which interacted with the quality factor of mother liquor (fine liquor + 0 m3 molasses), and 2 hours of cooking time, Where the results of the interaction of this factor produce a percentage of sugar with a size larger than 0.8 mm as much as 80%.
Investigation on Environmentally Polluted Water Hyacinth with Banana Fibre Reinforced Composite Absorption Properties
Authors: Ajithram Arivendhan , Winowlin Jappes J.T. , Perumal Sudalai , Kumar S. Dinesh , Manoharan Madhanagopal
Published: February 2024

A study of hyacinth plant fibres derived from aquatic wastewater aimed at developing lightweight, durable synthetic materials reinforced with banana fibres. The availability and sustainability of banana fibre make it one of the best choices for natural fibres. Traditional materials are extremely heavy, heavy, and expensive when compared to banana fiber materials. Their strength, lightness, and affordability make them ideal for this purpose. Recently, natural fibres have gained attention from scientists as reinforcement materials for polymeric composites and technical applications. There are many advantages to using natural fibres, including continuous supply, easier handling, and biodegradability. Particle boards on the market have a lower hardness strength than banana fibre composite boards. ASTM standards determine parameters such as hardness strength and absorption. According to their hardness strength, banana composites have hardness values of 95 shore D. The absorption levels of banana composites can be increased by 15 to 30%, depending on reinforcement. Compared to the other samples, 30% of the composite samples were able to achieve the high performance. The use of metal as a wood alternative for automobile bodies has been found to be promising in a number of applications.
Linear IgA bullous dermatosis induced by atezolizumab: a case report
Authors: Almutairi Seba , Alessa Dana
Published: February 2024

Linear IgA Bullous Dermatosis (LABD) is a rare immune-mediated vesiculobullous disease that was reported to be induced by infections or medications. Atezolizumab is a monoclonal antibody targeting programmed cell death ligand-1 (PD-L1), it has been used to treat multiple cancers. Here, we report a case of drug induced LABD following the administration of Atezolizumab.
The self-management model can increase the immunity of people with HIV and AIDS during the COVID-19 pandemic
Authors: Mobalen Oktovina , Raka I Made , Fabanyo Rizqi Alvian
Published: February 2024

Cases of people living with HIV and AIDS continue to increase from year to year, necessitating a focus on maintaining their health. To ensure their well-being, individuals with HIV/AIDS must be vigilant in preserving their immunity, especially during COVID-19 pandemic. This research aimed to enhance the immunity of people with HIV and AIDS during the COVID-19 pandemic utilizing a self-management model approach. The research employed a quasi-experimental design with pretest and posttest measurements, involving a sample of 30 HIV and AIDS patients in Sorong City, selected through purposive sampling technique. Independent variable in this research was the self-management model, which measured using Self-Management Model Guidebook and dependent variable was increasing the immunity of people with HIV and AIDS, which was measured using Self Reporting Questionnaire (SRQ) and CD4 cell observation. Data were analyzed using Wilcoxon test with significance level for these tests was set at 95%, with α ≤ 0.05. Analyzing the SRQ results of HIV/AIDS patients before and after the intervention, indicated a significant difference with a Sig. (2-tailed) of 0.044 < 0.05. This suggests a notable change in the SRQ results of HIV/AIDS patients. Additionally, the analysis of CD4 cell values before and after the intervention, yielded a Sig. (2-tailed) of 0.000 < 0.05, signifying a difference in the CD4 cell results of HIV/AIDS patients. In conclusion, implementing the self-management model with the four management functions from Planning, Organizing, Actuating, and Controlling (POAC) over a period of 30 days for HIV and AIDS patients during the COVID-19 pandemic can enhance both mental and psychosocial immunity, as well as physical immunity. The findings of this research provide valuable information to health workers, recommending the adoption of the Self-Management Model Guide intervention to enhance the immunity of individuals with HIV and AIDS.
Reliability and Mean Time to System Failure of a Parallel System' by Using One or Two Decimal Random Data Points
Authors: Kaur H , Sharma S K
Published: February 2024

Focusing on Weibull failure rules, which govern the stopping of components, this work evaluates reliability metrics such as stability and the mean time to system failure (MTSF) of a structure that is parallel. These metrics' behaviour has been seen for one or two decimal random values of component failure rates, operation times, form parameters, and the total quantity of components used in the parallel structure. In order to analyze the variation in the ethics of reliability as well as MTSF, the particular case of the Weibull distribution has also been taken up.
Nut, Self-Locking, 0.7500 thru 1.5000 Thread Sizes, UNS S66286, 160,000 psi, 800 °F, UNJ Thread – Procurement Specification
Authors:   E-25 General Standards for Aerospace and Propulsion Systems
Published: February 2024

This specification establishes the requirements for self-locking wrenchable nuts with thread sizes 0.7500 thru 1.5000 inches.

The nuts are made of corrosion and heat resistant precipitation hardenable iron base alloy of the type identified under the Unified Numbering System as UNS S66286 and of 160,000 psi axial tensile strength at room temperature, with maximum conditioning temperature of parts at 800 °F.
Findings from a national evaluation of social work field education programs in Liberia, West Africa
Authors: Tuggle Felicia , Banks Sevaughn , Gbessage Sylvestine
Published: February 2024

Program evaluation is an integral component of social work field education and continuous social work programmatic improvement. To conduct an inaugural national survey of social work field education programs in Liberia, West Africa, Made in Africa Evaluation (MAE) was used to design and implement a national evaluation of social work field education programs. The evaluation was led by and implemented with Liberian social work faculty and staff. Thirty-six field supervisors completed a quantitative survey. Results were used to assist programs identify strengths and areas for improvement. The MAE approach guided analysis and discussion of evaluation results. Findings revealed an emerging credentialed and experienced pool of field supervisors with high exposure and endorsement of human rights concepts, which was a strength. Field agencies were clustered in the city center of Montserrado County, the county seat for Monrovia-Liberia’s capital. Field agencies’ missions and services aligned with health, education, and gender equality sustainable development goals. Field agency supervisors provided few opportunities for students to practice macro based developmental social work activities such as advocacy and community work, an area identified as needing improvement. Challenges included Liberian social work faculty’s lack of experience in conducting evaluation research, insufficient access to scholarly databases to obtain research articles, and expensive data management platforms. Collaboration was recommended as a strategy to build evaluation capacity. 
How to reference using ASWNet style:
Tuggle, F., Banks, S. and Gbessage, S. (2023). Findings from a national evaluation of social work field education programs in Liberia, West Africa.  African Journal of Social Work, 13(6), 273-284. https://dx.doi.org/10.4314/ajsw.v13i6.1
Visit journal website: https://ajsw.africasocialwork.net
Microbial evaluation of borehole water used by selected bakeries in Ijebu-North, Ogun State, Nigeria
Authors: Egberongbe H.O. , Adekola H.A. , Adewale A.O. , Popoola D.O. , Wahab K.A. , Osipitan G.O.
Published: February 2024

Water is one of the most important components of dough systems used to produce bread and other bakery products. Water could serve as a direct or indirect source of microbial contamination during baking, handling, or packaging, thereby affecting the quality and safety of bakery products. This study investigated the presence of faecal coliforms in water sources of selected bakeries in Ijebu North Local Government Area. Water samples were collected from the main sources of three bakeries located in the Ijebu North Area. Physical and microbiological parameters were then investigated and compared to the WHO guidelines. The average temperature and pH ranged between 24.30 and 25.27oC and between 6.40 and 6.73, respectively. The average total bacterial and coliform counts of the water samples collected from the three bakeries were in the ranges of 1.80-3.60 x 104 CFU ml−1 and 1.60-2.70 x 104 CFU ml–1, respectively (p < 0.0001). Twenty-nine isolates comprising four species (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella spp.) were observed in this study. The study showed that all water samples under analysis were tainted with faecal coliform, which makes the water unsafe for use in bakeries.
Time to treat the climate and nature crisis as one indivisible global health emergency
Authors: Abbasi K. , Ali P. , Barbour V. , Benfield T. , Bibbins-Domingo K. , Hancocks S. , Horton R , Laybourn-Langton L. , Mash R. , Sahni P. , Sharief W.M. , Shehab A. , Yonga P. , Zielinski C.
Published: February 2024

This editorial is being published simultaneously in multiple journals. It highlights now as the time to treat the climate and nature crisis as one indivisible global health emergency.
Screening of meat sold for human consumption in Benue State, Nigeria for antibiotic residues
Authors: Onminyi N.O. , Agada C.A. , Luga I.I. , Ofukwu R.A. , Onyeyeli P.A.
Published: February 2024

The problem of veterinary drug residues in food of animal origin is of great importance in developing countries. The concerns are mostly  related to food safety and the development of antibiotic-resistant pathogens. This study was carried out during the hot dry season  (March) between 2016 – 2018 to detect antibiotic presence in beef, chevon and pork sold for human consumption in abattoirs in Benue  state. Thirty-nine samples each of 100-150g of kidney, liver and muscle were collected from cattle, goats and pigs making a total of 351  samples from abattoirs across the three geopolitical zones of Benue state. The samples were screened for multidrug residues using the  modified agar gel diffusion method. A total of 144 were positive out of which 40.3% (58/144) were beef, while 29.2% (42/144) and 30.5%  (44/144) were chevon and pork respectively. From the results of this study, it could be inferred that the meat consumed within Benue  State contains residues of antibiotics possibly because of non-adherence to the withdrawal period by farmers and lack of knowledge of its  consequences on the consumers.
Efficacy of the combination of cyclosporine and sodium hyaluronate eye drops on dry eye syndrome
Authors: Shen Lei , Zhao Nana , Wang Xue , Qing Shuyan
Published: February 2024

Purpose: To investigate the efficacy and adverse effect of cyclosporine combined with sodiumhyaluronate (SH) eye drops on dry eye syndrome (DES).Methods: 148 patients with DES treated in Nanjing Drum Tower Hospital Group Suqian Hospital,Jiangsu Province, China between January 2022 and February 2023 were randomly assigned to control(70 cases) and study groups (78 cases). Control group was treated with SH eye drop (1 drop each onboth eyes 5 - 6 times a day, for 2 months), while study group was treated with both SH (the samedosage and use with control group) and cyclosporine eye drop (1 - 2 drops each for both eyes, 4 - 6times a day, for two months). Tear film stability indices such as schirmer I test (SIT), tear break-up time(BUT) and corneal fluorescein stain (FL) of both groups were analyzed before and after therapy.Results: There was no significant difference in BUT, SIT and FL score between the two groups beforetreatment. Compared with before treatment, BUT and SIT increased significantly (p < 0.05), while FLscore dropped significantly in both groups after treatment (p < 0.05). After treatment, study groupshowed significantly higher BUT and SIT levels, and significantly lower FL score than control group (p <0.05).Conclusion: The combination of cyclosporine eye drops with SH eye drops is effective in treating DES.This combination regimen protects tear film stability, effectively alleviates DES symptoms, improvesocular surface and meibomian gland function, and also increases lacrimal river height, withoutincreasing adverse reactions. Further studies will be required, to provide more evidence for clinicalapplication of this combination regimen.
Venetoclax in combination with azacitidine or decitabine in relapsed/refractory acute myeloid leukemia
Authors: Che Yue , Tan Wanqing , Liu Ying , Liu Haitao , Li Lanlan , Qin Fangmei
Published: February 2024

Purpose: To investigate the clinical effects of venetoclax combined with azacitidine or decitabine in relapsed/refractory acute myeloid  leukemia.

Methods: 208 eligible first-line participants, who were diagnosed and treated for relapsed/refractory acute myeloid leukemia  between January 2022 and December 2022, were recruited from the Department of Hematology of Loudi Central Hospital, China. The  patients were randomly divided into study and control groups at the point of recruitment. Patients in the control group received  venetoclax combined with decitabine, while those in the study group received venetoclax in combination with azacitidine. Clinical data for  the two groups were recorded. The primary endpoints of this study included efficacy, routine blood indices, and adverse reactions.  

Results: There was no statistically significant difference in baseline characteristics between the two groups (p > 0.05), indicating  comparability. The total effectiveness of the treatment (i.e., efficacy) in the study group was higher than in the control group (p < 0.05),  while the control group had a higher risk of platelet, red blood cell, and neutrophil absolute count reduction than the study group (p <  0.05). The platelet count and hemoglobin level were lower in the control group after treatment compared to the study group (p < 0.05).  

Conclusion: The combination of venetoclax with azacitidine improves the efficacy and blood routine indices of patients with relapsed/ refractory acute myeloid leukemia, while reducing adverse reactions.
Effect, main targets and molecular mechanisms of glycyrrhiza-derived flavonoids on malignant tumor in comprehensive cancer treatment
Authors: Hu Wei , Ma Wenzhe , Li Bo , Hou Yu , Dai Rongyang
Published: February 2024

Glycyrrhiza flavonoids (GF) are essential antitumor components of Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata roots and  tubers, with antioxidant, anti-inflammatory, antibacterial, immune-enhancing amongst other properties. In recent years, significant  progress has been made in understanding the mechanisms and targets of GF in various pharmacological settings. This review summarizes the clinical value, targets and research progress of the molecular mechanisms underlying GF in the treatment of malignant  tumors. This will provide as a theoretical foundation for further studies into GF as a therapeutic option in the management of cancerous  tumors.
MiR-128-3p inhibits the proliferation, migration and invasion of human nasopharyngeal carcinoma cells via EMT
Authors: Li Jingli , Wang Hui
Published: February 2024

Purpose: To investigate the effect of overexpressing miR-128-3p on the migration, invasion, and proliferation of human nasopharyngeal  cancer cells, and associated pathways.Methods: Cell counting kit-8 (CCK-8) and clone creation tests were used to investigate the effect of miR-128-3p inhibitor on the growth of  C666-1 cells. The inhibitor control and miR-128-3p inhibitor were transfected into human nasopharyngeal cancer cells (C666-1) and  allowed to incubate for 48 h. Cell migration and invasion assays were conducted using Transwell and Scratch assays. Cell cycle was assessed using propidium iodide (PI) single-staining method, while expression of miR-128-3p was evaluated by quantitative reverse  transcription-polymerase chain reaction (qRT-PCR). Expression levels of vimentin, E-cadherin, and N-cadherin were determined by  Western blot.Results: MiR-128-3p inhibitor transfection in C666-1 cells significantly increased cell proliferation, cell viability, and clonal proliferation,  and also significantly reduced miR-128-3p expression levels, and enhanced cell migration and invasion. In C666-1 cells, inhibition of  miR-128-3p induced epithelial mesenchymal transition (EMT).Conclusion: MiR-128-3p inhibits nasopharyngeal cancer cells from proliferating, migrating, and invading by regulating epithelial   mesenchymal transition. MiR-128-3p may therefore be a viable therapeutic target for nasopharyngeal cancer. Future studies are  required  to yield pertinent data in support of this hypothesis.
Small molecule inhibitor azd1480 reverses radiotherapy resistance in NSCLC by targeting JAK2/STAT3 pathway
Authors: Mao Ying , Yao Yang , Liu Li
Published: February 2024

Purpose: To investigate the effect of small molecule inhibitor AZD1480 on radiotherapy resistance in non-small cell lung cancer (NSCLC),  and the involvement of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway in the process.

Methods: Radiation-resistant cell lines A549-20F, A549-30F, A549-40F and H460, H46040F, H460- 40F, and H460-40F were established, and  expressions of proteins related to JAK/STAT pathway, mitogen-activated protein (MAPK) pathway and transforming growth factor-β (TGF- β) were assayed. The JAK2V617FH460 overexpression cell line and JAK2H460 cell line were established, and expressions of ATGL and  CPT1A were compared. The H460 cells and H460-40F cells were treated with JAK2 small molecule inhibitor AZD1480, and the expressions  of ATGL, CPT1A and JAK2/STAT3 pathway-related proteins were compared. The survival and proliferation of cell lines were also compared. 

Results: The JAK/STAT pathway was significantly enriched, and MAPK and TGF-β were up-regulated. In H460 cells, JAK2/STAT3  route was obvious, suggesting that radiotherapy activated JAK2/STAT3 pathway in NSCLC cells. Significant down-regulations of p- JAK2Y1007, JAK2, p-STAT3s727, STAT3, ATGL and CPT1A proteins expressions were seen in H460 + AZD1480 group, relative to H460 group, but protein levels of p-JAK2Y1007, JAK2, p-STAT3s727, STAT3, ATGL and CPT1A were significantly lower in H460-40F + AZD1480 group than  in H460-40F group (p < 0.05). The survival and proliferation rates were significantly lower in A549 + AZD1480 group than in A549 and  A549-40F groups (p < 0.05).

Conclusion: Radiotherapy up-regulates the expressions of ATGL and CPT1A in NSCLC cells by activating the  JAK2/STAT3 pathway, while AZD1480, a small molecule inhibitor, reverses the radiation resistance of NSCLC by targeting JAK2/STAT3  pathway and key enzymes of lipid metabolism. Therefore, azd1480 may enhance clinical treatment efficacy in NSCLC patients by reducing  radiation resistance.
Anti-parkinsonian, anti-inflammatory, anti-microbial, analgesic, anti-hyperglycemic and anticancer activities of poly-fused ring pyrimidine derivatives
Authors: Bafail Rawan S.M. , Samman Waad A.
Published: February 2024

Purpose: To investigate the anti-inflammatory, anti-cancer, anti-parkinsonian, anti-microbial, analgesic,  and anti-hyperglycemic  properties of a variety of poly-fused pyrimidine derivatives.

Methods: A novel series of fused pyrimidine derivatives 1-6 were synthesized by reacting amino  pyrazole derivatives with active  methylene derivatives to give the corresponding compounds 1-6. Anti-parkinsonian activity was investigated with benzotropene as a  reference drug, anti-inflammatory effect  in mice was evaluated using carrageenan in paw edema with indomethacin as reference drug,  anti-microbial activity was assessed using nutritional agar with ciprofloxacin and ketoconazole as reference  drugs, analgesic activity  was evaluated using valdecoxib as reference drug, anti-hyperglycemic activity  was investigated using alloxan and sucrose models (SLM)  with pioglitazone as reference drug and  anticancer activity was investigated using the MTT micro-cultured tetrazolium assay method  with  doxorubicin as reference drug.

Results: Pyrimidine derivatives 1-6 possess significant active anti-parkinsonian, anti-inflammatory,  anti-microbial, analgesic, anti-hyperglycemic and anticancer activities in comparison to the reference drugs  used for each model.  Compared to Benzotropene®, compounds 1 and 3 showed a significantly stronger  anti-parkinsonian activity (p < 0.03). Compound 3  showed a significantly stronger anti-inflammatory  effect than Indomethacin® (p < 0.05). Compounds 5 and 6 exhibited significant anti- microbial activity  compared to ciprofloxacin® (p < 0.05). Compounds 4 and 6 exhibited significantly improved analgesic  activity as  compared to Valdecoxib® (p < 0.01). Compounds 1 and 3 exhibited significantly higher anti-hyperglycemic effects in SLM model when  compared to pioglitazone® (p < 0.02). Compound 5  demonstrated the highest activity against human colon cancer cell line (HT-29) and  human prostate  cancer cell line (DU145), and also, significantly improved level of efficacy against human lung cancer  cell line (A549)  compared to Doxorubicin® (p < 0.02). 

Conclusion: Using the six pyrimidine derivatives 1 - 6 as a lead molecule, a novel class of clinically  beneficial anti-cancer, anti-inflammatory, anti-microbial, analgesic, and anti-hyperglycemic drugs may  be produced.
Editorial Note
Authors: Chief Editor
Published: February 2024

This is my final editorial note to our esteemed readers before I turn the editorship helm over to a new Chief Editor who will take the Journal to the next level. Having an opportunity to serve as the Chief Editor has been a privilege and honour, however, it is the right time to quit well.
Examining Digital Divide in Secondary and Primary Education Online Content Users Based in Tanzania
Authors: Wazoel Lubua Edison
Published: February 2024

This paper determined the digital divide among secondary and primary education online platforms in Tanzania. The study addressed three key aspects: first, it determined the contribution of facilitating conditions in the digital divide among secondary and primary school learners. Secondly, it determined how the quality of existing secondary and primary education digital platforms defines the current status of the digital divide. Lastly, the study provides steps to be taken by stakeholders of education in addressing the digital divide in the context of secondary and primary education. The study used the qualitative approach. First, it used government reports and other organisational publications to obtain statistical information on facilitating conditions for educational digital services. Secondly, it studied 302 online reviews by users of seven (7) digital platforms for secondary and primary education contents in Tanzania. In the first set of results facilitating conditions such as ownership of smartphones, computers, Televisions, and access to the Internet still contribute to the digital divide among users of secondary and primary education platforms. In the second set of reviews, the study observed the following nature of reviews submitted by users to studied online platforms. The first category had a positive view of digital platforms. This is a positive view submitted to the platform on its usefulness. In all platforms, users were of the view that the platforms were useful. Another category was that of poor technical quality. This view reflects the perception of viewers that the quality of the accessed platform was poor.  In this category, users were more uncomfortable with the inability of the platform to launch appropriately. The third category was about the quality of the contents. In all platforms, users suggested that the contents were inadequate. With the guidance of policies, all stakeholders need to engage together in addressing observed issues of the digital divide.
„Każdy zna się na AI”. Przegląd badań polskiej opinii publicznej na temat sztucznej inteligencji
Authors: Nowina Konopka Maria
Published: February 2024

„Everyone Knows AI”. A Review of Polish Public Opinion Polls on Artificial Intelligence

A study on the perception of artificial intelligence in Poland indicates a growing awareness of this concept. However, many people still have false ideas about this, often confusing AI with automation or robotisation. The survey results suggest that Polish people are confused and do not fully understand what artificial intelligence is. The article presents the results of research based on a systematic review of available internet sources regarding public opinion on artificial intelligence in Poland. A total of 12 different studies, conducted in the six years to 2023, were analysed. The analysis of the research material allowed for drawing five main conclusions regarding: 1) understanding the concept, 2) experiencing the presence of technological artifacts, 3) the scope of acceptance for intelligent machines, 4) the issue of substitutability and 5) confusion. The conclusions from the analysis suggest that Polish people are beginning to understand the role of artificial intelligence, but they still have many questions and concerns about it, and as AI becomes more popular in everyday life, further changes in the way it is perceived can be expected.
A Review Article on Analysis and Design of Water Distribution Network for Jabalpur Cantonment Board Area
Authors: Aniket Soge, Tarun Ghorse and Rajesh Ingole
Published: February 2024

The Jal Jeevan Mission (JJM) stands as a transformative initiative aimed at ensuring accessible and potable water supply to
every rural household across India. This review article delves into assessing the comprehensive impact of the JJM on rural water
supply systems, with a primary focus on evaluating its assessment methodologies, distribution network designs, and analytical
aspects.The assessment section scrutinizes the strategies employed under the JJM for gauging the water needs of rural
communities. It examines the mission's effectiveness in identifying and addressing the diverse and dynamic requirements of
different regions, considering factors such as population density, topography, and water quality.Furthermore, the design of the
distribution network within the JJM framework is critically analyzed. This includes an exploration of the planning, engineering,
and implementation methodologies used to establish robust and efficient water supply networks in rural areas. The article delves
into the technological innovations, if any, adopted for optimizing water distribution, storage, and management.
Benefício do exercício físico em pacientes com fibromialgia. Uma revisão integrativa
Authors: Del Borgo Gabriel Martins , Kravchychyn Claudio , Arantes Luciane Cristina , Silva Luiz Augusto da , Brasil Marcos Roberto
Published: February 2024

A fibromialgia (FM) é caracterizada por dor difusa e sensibilidade das articulações, músculos e tendões que não possui cura. Dessa forma intervenções são necessárias para auxiliar na melhora dos sintomas que afetam esses pacientes e possibilitar uma melhor qualidade de vida. Dentre as intervenções, encontram-se as terapias alternativas, enquadrando-se entre essas os exercícios físicos. Com isso, este trabalho teve por objetivo apresentar as formas pelas quais o exercício físico pode ser útil ao paciente fibromiálgico, sobretudo no que tange a melhora na qualidade de vida e, consequentemente, dos seus sintomas, por meio de uma revisão da literatura. Para tal objetivo, uma revisão de literatura integrativa, que contou com a busca nas bases de dados SciElo, Web of Science e Medline em um recorte tempo de 2018 até 2022, com o auxílio dos descritores Fibromyalgia e Physical activity. Após leitura de título, resumo e texto completo, 46 trabalhos foram incluídos. Desses, 29 trabalhos apontaram as intervenções com atividades aeróbicas como método indicado para melhora de sintomas e 16 trataram das atividades anaeróbicas como intervenção, além de uma produção que abordou as duas vias metabólicas. Diante disso, pode-se concluir que o exercício físico bem orientado e planejado, buscando associar o treinamento aeróbico com o treinamento anaeróbico, levando em consideração as individualidades do paciente em relação a FM, apresentam-se como ótimas aliadas na redução de sintomas relacionados a fibromialgia.
Relación entre práctica de musculación y fuerza de prensión manual de atletas de jiu-jitsu brasileño
Authors: Salinas Johan Andrés Robalino , Azevedo Ana Paula da Silva , Calvo Adriano Percival Calderaro , Ferreira Jacielle Carolina
Published: February 2024

Este estudio tiene como objetivo comparar la fuerza de prensión manual entre atletas de jiu-jitsu brasileño (JJB) que practican musculación y aquellos que no lo practican, explorando índices de fuerza que evalúen la máxima fuerza y la resistencia, así como sus respectivas asimetrías. La muestra incluyó 22 atletas masculinos de JJB, separados en dos grupos según su entrenamiento: practicantes de musculación (PM) y no practicantes (NPM). Ambos grupos se sometieron a una prueba isométrica de presión manual, aplicando 30 segundos de máxima fuerza con un dinamómetro (EMG System do Brasil®). Los datos se procesaron en Matlab® para obtener índices de fuerza: fuerza máxima (Fmáx), media (Fmed) e índice de fatiga (IF). Se utilizó la prueba t de Student para el análisis. No hubo diferencias significativas en la Fmáx de mano derecha (35,08 ± 5,30 y 32,75 ± 7,33; p=0,14), mano izquierda (30,77 ± 6,31 y 29,57 ± 7,32; p=0,35) y asimetría (13,11±10,67 y 11,98 ± 9,85; p=0,78) entre PM y NPM. Los valores de IF tampoco difirieron (derecha: 30,48 ± 18,89 y 36,48 ± 11,62, p=0,36; izquierda: 35,72 ± 12,99 y 35,13 ± 13,17, p=0,95); excepto para asimetría (22,67 ± 13,29 y 44,69 ± 28,45; p=0,02). El entrenamiento con pesas en practicantes de JJB no aumenta significativamente la fuerza máxima de prensión manual, pero reduce la asimetría en miembros contralaterales para el índice de fatiga.
Caracterización de la composición corporal por posición de juego de un equipo de fútbol
Authors: Villeda Morales Diane Elizabeth
Published: February 2024

La composición corporal de vital importancia para deportes complejos como el fútbol, para poder identificar el talento deportivo, evitar lesiones y establecer objetivos de entrenamiento, mejorando el rendimiento del deportista. De esta manera, la siguiente investigación tiene el objetivo de evaluar la composición corporal de 25 futbolistas masculinos, según la posición de juego que ocupan en el partido. El estudio fue de tipo descriptivo transversal; se utilizó equipo de bioimpedancia, para evaluar a cada jugador, presentando los resultados como parámetros que pueden tomarse para este tipo de deportes en este mismo ámbito de entrenamiento y ambiente. Se obtuvieron escasas diferencias entre los jugadores por posición de juego, aunque los porteros presentaron las tallas mayores y porcentajes de grasa más altos, en relación con otras posiciones, además de presentar más masa muscular. Los mediocampistas presentaron una correlación negativa de -0,5655, entre porcentaje de grasa y masa muscular. Los defensas presentaron una correlación de 0,5725 entre el porcentaje de grasa contra masa muscular, lo que indica una relación directa. Como conclusiones, los mediocampistas presentan correlación positiva en masa muscular e hidratación, esto debido a su masa muscular.