bluuebunny/crossref_metadata_2025 huggingface dataset:
De la Commune à l’anarchie de Charles Malato : le destin de l’écrivain libertaire
Authors: Kaczmarek Tomasz
Published: December 2023

From the Commune to Anarchy by Charles Malato: the destiny of the libertarian writer

Charles Malato has gone down in posterity as the author of novels, memoirs and especially plays in which he castigates the excesses of power. Two events are at the origin of the birth of Malato’s vocation as an anarchist writer: the condemnation of his parents to banishment in New Caledonia and the meeting of the young Charles with Louise Michel. It is in this context that this article proposes to study the autobiographical text of the French author From the Commune to Anarchy which allows us to understand the inner evolution of the somewhat carefree adolescent towards destiny of a revolutionary able to use his pen as a formidable weapon. From then on, the analysis of the text accounts for Malato’s political awareness and his subsequent involvement in social issues, as well as highlighting the style of his language, as cruel as it is grotesque, which will upset the fragile minds of the bourgeois. In short, the exploration of the work constitutes a kind of propaedeutic to the subversive work of Malato whose universality attests to its undeniable topicality.
« Le moelleux, la chaleur, ce sont les femmes ! » : figures de femme dans Il pleut dans ma maison et Off et la lune de Paul Willems
Authors: Tymura Karolina
Published: December 2023

“The softness, the warmth, these are the women!”: female figures in Il pleut dans ma maison and Off et la lune by Paul Willems

Paul Willems, 20th-century Belgian playwright, did not shy away from showing many female figures in his plays, and he did so with great attention to detail. Through a thorough analysis, of the following plays : Il pleut dans ma maison and Off et la lune, it is possible to draw analogies between the heroines he created, which might allow to identify the topoi most often used by the Belgian playwright. We used the historical method, notably the selection, fusion, interpretation and ordering of facts. In addition, the method of literature analysis with particular emphasis on the analysis of source texts and the comparative method were used. Based on the analysis carried out, we established that the following topoi of women appear in the two Willems’ plays selected for analysis: a woman as an incomprehensible being, a romantic woman, a traditional woman and a liberated woman.
Đặc điểm lâm sàng, cận lâm sàng của sản phụ đẻ non tại Bệnh viện Trung ương Thái Nguyên và một số yếu tố liên quan
Authors: Nguyễn Thị Hồng , Nguyễn Tiến Tới , Nguyễn Thị Duyên , Nguyễn Phương Sinh , Cao Thị Quỳnh Anh , Hoàng Quốc Huy
Published: December 2023

Mục tiêu: Mô tả đặc điểm lâm sàng, cận lâm sàng và nhận xét một số yếu tố liên quan của sản phụ đẻ non tại Bệnh viện Trung ương Thái Nguyên năm 2021 - 2022.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang 155 sản phụ đẻ non tại Bệnh viện Trung ương Thái Nguyên từ tháng 1 năm 2021 đến tháng 12 năm 2022.

Kết quả và kết luận: Sản phụ có biểu hiện kết hợp nhiều triệu chứng: Đau bụng kèm ra máu hoặc ra nước hoặc ra dịch âm đạo khi vào viện chiếm tỷ lệ cao nhất (67,1%). Sản phụ có cổ tử cung mở 1 - < 3 cm khi vào viện chiếm tỷ lệ cao nhất (49,7%). Sản phụ có tình trạng thiểu ối chiếm 29%. Sản phụ có nhiễm khuẩn tiết niệu khi vào viện chiếm tỷ lệ cao là 63,2%. Một số yếu tố liên quan đến đẻ non là: tuổi thai mà sản phụ dừng làm việc và số lần khám thai, với mức ý nghĩa thống kê p < 0,05.
Bất thường di truyền ở bệnh nhân vô tinh đến khám tại Bệnh viện Phụ sản - Nhi Đà Nẵng
Authors: Phạm Chí Kông , Nguyễn Thị Phương Lê , Nguyễn Văn Hiền , Trần Đình Vinh
Published: December 2023

Mục tiêu: Khảo sát các bất thường di truyền ở bệnh nhân vô tinh đến khám và điều trị tại Bệnh viện Phụ sản - Nhi Đà Nẵng.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang gồm 62 bệnh nhân vô tinh đến khám tại Bệnh viện Phụ sản - Nhi Đà Nẵng từ tháng 12/2020 - 9/2023.

Kết quả: Tỉ lệ bất thường di truyền là 11,3% (07/62) bao gồm hội chứng Klinefelter chiếm 3,2% và vi mất đoạn nhiễm sắc thể (NST) Y chiếm 8,1%. Không ghi nhận trường hợp nào vi mất đoạn NST Y ở vùng AZFa và AZFb. Tỉ lệ vi mất đoạn NST Y vùng AZFc, AZFd và AZFc+d lần lượt là 60%, 20% và 20%. Tỉ lệ đa hình NST là 37,1%, trong đó, có 1 trường hợp tăng chiều dài vùng dị nhiễm sắc chất trên cánh dài NST Y (46, XY,Yqh+), chiếm 4,3% (1/23).

Kết luận: Vi mất đoạn NST chiếm tỉ lệ cao nhất trong số các bất thường di truyền. Trong nghiên cứu này, đa hình NST chiếm tỉ lệ tương đối cao .
Khảo sát tình trạng rối loạn niệu dục ở phụ nữ mãn kinh huyện Hòa Vang thành phố Đà Nẵng
Authors: Nguyễn Đình Phương Thảo , Hoàng Thị Minh Hòa , Dương Thị Kim Hoa
Published: December 2023

Mục tiêu: Khảo sát tỷ lệ rối loạn niệu dục ở phụ nữ mãn kinh huyện Hòa Vang thành phố Đà Nẵng năm 2023 và tìm hiểu một số yếu tố liên quan đến rối loạn niệu dục.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 196 phụ nữ đã mãn kinh tự nhiên được phỏng vấn và thăm khám tại 04 trạm Y tế của huyện Hòa Vang, thành phố Đà Nẵng trong tháng 8 năm 2023. Nghiên cứu được tiến hành thông qua khám phụ khoa và phỏng vấn các đối tượng nghiên cứu theo phiếu điều tra nhằm khảo sát tỷ lệ rối loạn niệu dục và tìm hiểu một số yếu tố liên quan.

Kết quả: Tỷ lệ rối loạn niệu dục ở phụ nữ mãn kinh: són tiểu gắng sức chiếm tỷ lệ cao nhất trong các triệu chứng rối loạn tiểu tiện ở phụ nữ mãn kinh (56,1%), tiếp đến là tiểu gấp (33,2%), tiểu đêm ≥ 3 lần chiếm 23%, tiểu rắt 23%, són tiểu thường xuyên và tiểu khó chiếm tỷ lệ 20,4% và thấp nhất là tiểu nhiều lần chiếm 8,7%. Sinh hoạt tình dục giảm chiếm tỷ lệ cao nhất trong các triệu chứng niệu dục ở phụ nữ mãn kinh (69,9%), âm đạo khô chiếm tỷ lệ cao trong các triệu chứng thiểu dưỡng âm đạo (54,1%), tiếp đến là âm đạo xung huyết dạng mảng/chấm chiếm 47,4%, cảm giác bỏng rát âm đạo 37,1%, không còn sinh hoạt tình dục 36,7%, giao hợp đau 28,2% và thấp nhất là âm đạo rỉ máu chiếm 10,7%. Có mối liên quan giữa thời gian mãn kinh với tiểu gấp, tiểu đêm, tiểu rắt, tiểu khó, són tiểu gắng sức, són tiểu thường xuyên và liên quan giữa pH âm đạo với tiểu rắt. Có mối liên quan giữa âm đạo xung huyết dạng mảng/chấm, không còn sinh hoạt tình dục, âm đạo khô, giao hợp đau và sinh hoạt tình dục giảm với thời gian mãn kinh.

Kết luận: Tình trạng rối loạn niệu dục ở phụ nữ mãn kinh chiếm tỷ lệ cao và có mối liên quan giữa pH âm đạo với tình trạng rối loạn niệu dục, giữa thời gian mãn kinh với rối loạn niệu dục.
Nghiên cứu sự thay đổi nội tiết sinh sản trong các thể bệnh lạc nội mạc tử cung ở phụ nữ vô sinh
Authors: Nguyễn Thị Khánh Quỳnh , Lô Hương Ly , Nguyễn Đắc Nguyên , Lê Minh Tâm
Published: December 2023

Mục tiêu: Khảo sát sự thay đổi nội tiết sinh sản trong các thể bệnh lạc nội mạc tử cung (LNMTC) ở phụ nữ vô sinh.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên những bệnh nhân có u LNMTC đến khám tại Trung tâm Nội tiết - Sinh sản và Vô sinh, Bệnh viện Trường Đại học Y - Dược Huế từ 1/2019 đến 9/2023.

Kết quả: Qua nghiên cứu 94 phụ nữ vô sinh có lạc nội mạc tử cung, ghi nhận 43,6% phụ nữ mắc LNMTC ở buồng trứng, 31,9% mắc lạc tuyến cơ tử cung và còn lại mắc đồng thời có cả hai thể. Có sự khác biệt có ý nghĩa thống kê giữa nồng độ LH và CA-125 giữa các thể LNMTC (p < 0,05) trong đó giá trị nồng độ LH và CA-125 cao hơn ở thể phối hợp cả hai thể LNMTC. Có sự khác biệt có ý nghĩa thống kê giữa các khoảng giá trị của FSH, LH trong từng thể LNMTC (p < 0,05) trong đó các thể bệnh LNMTC đa số có nồng độ FSH trong khoảng 5 - 12 UI/L (lần lượt là 83.3%, 87.8% và 52.2%), trong thể chỉ có LNMTC tại BT, 73.2% thuộc nhóm nồng độ LH cao (≥ 5 UI/l) trong khi 2 nhóm còn lại tỷ lệ giữa nhóm có nồng độ LH cao và thấp là tương đương.

Kết luận: Giá trị nồng độ LH, FSH, và CA-125 cao hơn ở thể phối hợp cả hai thể LNMTC. Không có sự khác biệt về các chỉ số thể hiện chức năng sinh sản khác như AMH ở các thể lạc nội mạc tử cung.
Barriers to access of hematopoietic stem cell transplantation
Authors: Feliciano João Victor Piccolo , Lopes José Carlos , Weiller José Alexandre Buso , Bulgareli Jaqueline Vilela
Published: December 2023

Introduction: Hematopoietic stem cell transplantation is a therapy for which even countries with universal health systems face challenges to ensure its access to the population. Barriers to access can be characterized as geographic, organizational, socioeconomic and of information. Objective: To conduct an integrative review of barriers to access of hematopoietic stem cell transplantation. Methods: Databases chosen were BVS, PubMed and Scopus. Population and phenomenon were established, respectively as “hematopoietic stem cell transplantation” and “barriers to access” with descriptors in Portuguese and English. 22 articles, published between 2012 and 2022, were selected. Results: Access was hampered by the distance to transplant center, in more populous regions, with high demand for services and transportation difficulties. There was better access in countries with higher GDP per capita, more installed transplant centers and for the population with higher income. Insurance coverage, support by public policies, assistance in academic centers, organized regulation and prioritization of emergencies facilitated access. The understanding of the diseases, the adherence to the treatments, the perception of survival by the patients and the skills of the professionals improved the access. Conclusion: All categories of access barriers were addressed, with multifactorial and interrelated origins, with the vulnerable population being the most affected.
Analysis of the Effectiveness of Drugs Interdiction Strategy in Indonesia: A Study on the National War on Drugs Policy
Authors: Akbar Hafiz Prasetia
Published: December 2023

This paper will evaluate the interdiction method that the Indonesian government employs in their ongoing war on drugs. The interdiction policy is divided into two components: first, reducing supply of drugs by intensifying crackdowns on illicit drug shipments from abroad and closing down hidden shipping lanes; and second, diminishing demand by enacting tough drug laws for users and traffickers alike in order to discourage the usage and labour for trafficking. The paper concludes that, like with any interdiction approach used globally, it is hampered by the balloon effect’s impact of route displacement and the hydra effect of the large incentive associated with trafficking, causing the inelastic nature of the drug trade. Although this study confirms that drug interdiction strategy is inefficient, interestingly it continues to be a popular policy among Indonesian politicians, law enforcers, and citizens, which could dissuade the desire for alternative approaches to addressing the illicit drugs issue.
MAMMOGRAPHICALLY DETERMINED ASYMMETRIES OF THE MAMMARY PARENCHYMA: CAUSES AND OPPORTUNITIES OF THEIR MAMMOGRAPHIC AND ULTRASOUND DIFFERENTIAL DIAGNOSIS
Authors: Pasynkov Dmitry V. , Merinov Sergei N. , Pavlikova Olga A. , Mukhamatgaleeva Luisa Kh. , Kokorina Serafima E. , Busygina Olga V. , Nasrullayev Magomed N. , Fedorov Alexey L.
Published: December 2023

The incidence of asymmetries is 1-2% of all mammographic studies performed. However, there is no data in the literature on the prevalence of individual causes for mammographically determined asymmetries, as well as information about the opportunities of mammography and ultrasound examination (U/S) in their differential diagnosis. The aim of the study is to assess the incidence of individual causes for mammographically determined asymmetries and the opportunities of mammography and ultrasound of the mammary glands in their differential diagnosis. Material and methods. The results of mammographic and ultrasound examination of 202 patients were analyzed, in whom zones of asymmetrically distributed breast tissue were detected during mammography. Results. Technical asymmetries were detected in 14 out of 202 cases (6.93%) and could not be adequately analyzed. The true ones were asymmetries without space-occupying lesions caused by asymmetric uneven distribution of glandular (as a rule) or fibrous tissue (161 out of 202; 79.70%), as well as asymmetric edema of the breast parenchyma not associated with edematous infiltrative form of breast cancer (1 out of 202; 0.50%). These cases have always required performing breast ultrasound. The causes of true asymmetries caused by the presence of a space-occupying lesion were malignant neoplasms (breast cancer; 7 out of 202; 3.47%), benign formations (cysts, fibroadenomas, granulomas, abscesses, hematomas, chronic mastitis and other focal benign processes; 11 out of 202; 5.45%). These cases also required to perform breast ultrasound. The cause of the true asymmetries were also postoperative scars (8 out of 202; 3.96%), the differential diagnosis of which did not require ultrasound, but it and/or magnetic resonance mammography were required to assess the condition of the scar for its possible malignant transformation. Conclusions. The largest proportion of mammographically determined asymmetries in the density of mammary parenchyma (79.70%) are physiological variants of asymmetrically distributed tissues of this organ; their differential diagnosis and that of asymmetries caused by space-occupying lesions, according to mammography findings, is difficult, which requires additional ultrasound of the mammary glands. At the same time, mammography makes it possible to confidently identify technical asymmetries of the breast requiring no use of ultrasound, however, the interpretation of such sets of mammograms does not seem correct.
THE MARKET FOR THE PRODUCTION OF WHITE CABBAGE AS AN ELEMENT OF FOOD SECURITY
Authors: Razin Oleg A. , Surikhina Tatyana N.
Published: December 2023

The article presents and analyzes the indicators of white cabbage production in Russia (by districts, subjects of the federation and categories of farms). The purpose of this study is to analyze the state of white cabbage production in the Russian Federation and in the world in terms of food security. Materials and methods. The information base of the research is information and scientific material, statistical data of the Food and Agriculture Organization of the United Nations (FAO), official periodicals of modern analytical centers. The study used general scientific methods of systematization, comparison and analysis of data. Study results. To increase the level of food security in Russia, it is necessary to ensure sustainable development of domestic production, physical and economic accessibility of high-quality food for the population. According to the new Food Security Doctrine, the strategic goal is to increase the export potential. The study revealed that about 70,150,406 tons of cabbage are produced. China is the largest cabbage producer in the world. In the Russian Federation, 14.3% of all cultivated areas of open ground crops are occupied for cabbage. The area under crop for cabbage in farms of all categories has decreased over the past six years. Many farmers and agricultural organizations refuse to grow cabbage due to its low profitability. The main cabbage production in 2022 is concentrated in the North Caucasus Federal District. In 2022, the volume of gross cabbage harvest amounted to 23,200.2 thousand tons. The current situation in the country makes it possible to implement import substitution of varieties and hybrids of white cabbage. Currently, the main task is to abandon the import of seeds of foreign breeding, and therefore it is important to focus on creating new hybrids that will be of high quality, good yield and shelf life, as well as resistance to diseases and pests. Conclusions. Today, the Russian Federation is under severe sanctions from the United States and European countries, so the issue of food security is acute. An important role in solving the problem of forming sufficient amounts of food resources belongs to the agro-industrial complex, which plays an important role in the country's economy. An important role belongs to the vegetable growing industry, which provides the population with a variety of vegetable products all year round. The country remains dependent on imported seeds, and for accelerated import substitution it is advisable to develop such forms of support as direct financing of seed production costs, provision of benefits, loans and guarantees. It is also necessary to develop a targeted state program for the transition of the industry to domestic seed material. According to analysts, Russia will be able to fully provide itself with seeds by 2025–2030.
THE PLACE OF LEGAL NORMS ON APPEALING AGAINST ACTIONS (INACTION) AND DECISIONS IN THE CRIMINAL PROCEDURE LAW OF RUSSIA: PROBLEM STATEMENT
Authors: Ibragimova Alisa M.
Published: December 2023

The article examines the criminal procedural norms governing criminal procedural appeal in the aspect of the main scientific directions on the topic under study. The purpose of the study is to determine the essence and the place of the legal norms of appeal in the criminal procedure law, the specifics of legal relations regulated by them. Materials and methods. To achieve the purpose of the study, the method of materialistic dialectics, logical, systemic and structural methods were used. The empirical basis of the study was made up of court decisions and the results of research performed by other authors. Study results. The nature of the emerging links between the legal norms of appeal in the Russian criminal procedure legislation is analyzed, the features of legal relations regulated by them are investigated, their place in the sectoral subject of criminal procedure regulation is determined. The main scientific directions on the subject under consideration, in conjunction with the author's conclusions, made it possible to identify a relatively independent area of the law on the topic under study. Conclusions. The author comes to the conclusion on heterogeneity of the legal norms of appeal, on different conditions for realizing the right to a complaint, depending on the stage of criminal proceedings and the subject of law. In connection therewith, a different legal regulation of legal relations in connection with the criminal procedure appeal is inevitable. The results of the study give the opportunity to conclude that the issues of appeal are not limited in their legal regulation by one universal legal institution of the industry and represent a more complex set of norms having relative independence within the branch of criminal procedure law.
CONSTITUTIONAL AND LEGAL CONSOLIDATION OF NATIONAL OBJECTIVES AND PRIORITIES IN THE SOCIAL POLICY OF THE RUSSIAN FEDERATION
Authors: Ivanova Olga A.
Published: December 2023

The purpose of the study is to identify the interdependency between the constitutional reform and changes in social institutions and to propose directions for the development of new constitutional provisions in the legislation of the Russian Federation. Materials and methods. The methodological instrumentarium is chosen taking into account the specific goals of the work. The dialectical-materialistic method of cognition made it possible to study the subject in development, in interrelation of all its individual manifestations and in interaction with related phenomena, to substantiate the advantages and disadvantages of various approaches to solving this issue. The methods of formal logic: description, comparison, analysis and synthesis made it possible to reveal and characterize in detail the legal, moral, ethical and other aspects of constitutional and legal transformations. The use of specific scientific methods of cognition: comparative legal, formal legal, statistical, structural and functional – made it possible to explore the problem under consideration in interrelations and interdependence, to identify certain trends, to make generalizations and conclusions. Study results. The relevance of the research topic is determined by the need to legally consolidate traditional Russian values and worldview guidelines, to preserve and pass the Russian civilizational code for future generations in conditions of a changing world order and defending the idea of a multipolar world. The Constitution of the Russian Federation, as amended in 2020, became the result of transformations in social institutions and the program for the development of the Russian society and the state for the future. The constitutional doctrine is evaluated in retrospect, the prerequisites for the 2020 constitutional reform are assessed, and its first results are analyzed. New constitutional and legal norms and their development in the legislation of the Russian Federation are analyzed, comparative legal characteristics of individual constitutional and legal novelties are given, and their importance in the system of constitutional and legal regulation of public relations is substantiated. Conclusions. The author comes to the conclusion about the public demand for the constitutional consolidation of institutional changes that have taken place and consolidated in the Russian society in the last three decades of constitutional development.
Evaluation of Eye Diseases Encountered in Cats: A Retrospective Study (2020-2023)
Authors: ÇATALKAYA Emine , ERSÖZ KANAY Berna , YAYLA Sadık , SAYLAK Nahit , BAYAT Ahmet
Published: December 2023

The eye is a sensory organ sensitive to external factors, infections, and metabolic disorders, and eye diseases have a very important place among surgical diseases. This study aimed to report the distribution of eye diseases encountered in cats brought to Dicle University Veterinary Faculty Hospital in the last 4 years (2020-2023) and to contribute to veterinary practice. The study material consisted of 291 cats of different ages, genders and breeds diagnosed with eye disease, brought to Dicle University Veterinary Faculty Animal Hospital between January 2020 and September 2023. Following the history of the cats, a detailed eye examination was performed and the diagnosed eye problem was recorded. In the cats included in the study, conjunctivitis (21.15%), keratitis (19.59%), corneal ulcer (14.09%), keratoconjunctivitis sicca (9.62%), glaucoma (3.44%), uveitis (4.12%), iris staphyloma (4.12%), symblepharon (3.78%), panophthalmitis (3.44%), corneal necrosis (3.09%), nictitans protrusion into the membrane (1.72%), chemosis (1.72%), entropion (1.37%), cataract (1.03%), hypopion (0.69%), proptosis (0.34%), local retinal detachment (0.34%) and dermoid cyst (0.34%) were seen. As a result, conjunctiva and corneal diseases were commonly encountered in cats. In order to prevent visual impairment, it is important not to neglect routine eye examinations and to diagnose and treat diseases early.
Cerebellar Perturbations of Combination Antiretroviral Therapy (CART): Can Bioflavonoids Help?
Authors:   Department of Anatomy, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria, Oremosu Ademola , Akang Edidiong ,   Department of Anatomy, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria, Dosumu Olufunke ,   Department of Anatomy, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria, Usman Isilamiyat ,   Department of Anatomy, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria, Akanmu Alani ,   Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria
Published: December 2023

Long term usage of combination anti-retroviral therapy (cART) has been associated with neurological disorders as a result of varying toxicities. This study was therefore designed to investigate the therapeutic potential of selected flavonoids (Naringenin and Quercetin) on cART-induced cerebellar disorders. Seventy Wistar rats were divided into seven groups as control, Naringenin (50 mg/kg), Quercetin (50 mg/kg), 24 mg/kg cART (Efavirenz + Lamivudine + Tenofovir regimen), 24 mg/kg cART + 50 mg/kg Naringenin, 24 mg/kg cART + 50 mg/kg Quercetin and 1% v/v dimethyl sulphoxide (DMSO) groups. The animals were euthanized on the 57th day, processed for oxidative stress markers, and basic histology. Results showed that the Purkinje cells were very distinct in groups that received cART with Naringenin, and cART with Quercetin, whereas the animals that received cART alone showed neurodegenerative changes in the Purkinje cells. Likewise, the malondialdehyde (MDA) levels increased significantly (p < 0.0001) in animals that received cART alone compared to control. There was also a concomitant significant decrease in the superoxide dismutase (p < 0.05), and catalase (p < 0.05) in cART treated group compared to control. Animals that received both cART and bioflavonoids had marked increase in antioxidant enzymes and decrease in MDA levels compared to cART treated group. Results of this study demonstrate that Naringenin and Quercetin have therapeutic benefits by potentiating the activities of antioxidant enzymes which prevents the onset/deleterious impact of reactive oxygen species on the cerebellum of the Wistar rat.
New ACR/EULAR 2022 classification criteria for ANCA-associated vasculitis
Authors: Beketova T. V.
Published: December 2023

The new 2022 classification criteria for antineutrophil cytoplasmic antibodies associated vasculitis (AAV), proposed by the American College of Rheumatology (ACR) and the European Alliance of Associations for Rheumatology (EULAR), was an important stage in the development of the doctrine of systemic vasculitis. Based on the analysis of large international cohorts, the criteria for granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis were revised, and classification criteria for microscopic polyangiitis were proposed for the first time. The creation’s history of the AAV classification criteria is discussed over the past three decades, and their limitations are considered. It should be noted, the ACR/EULAR 2022 criteria were developed for creating homogeneous groups of patients for scientific studies and cannot be widely used in clinical practice for the various AAV nosological forms diagnosis, primarily at early stage of the disease or mono organ damage (for example, kidneys). As before, decisive importance in AVV diagnostic belong to a detailed clinical analysis and a complete examination of patients to identify pathognomonic symptoms, including asymptomatic ones.
Rituximab in the treatment of Graves’ disease and endocrine ophthalmopathy. Opportunities and limitations
Authors: Panevin T. S. , Zotkin E. G. , Troshina E. A. , Lukina G. V.
Published: December 2023

Rituximab is a chimeric (mouse and human) monoclonal antibody against B-lymphocytes (CD20). This drug is widely used in rheumatology in the treatment of rheumatoid arthritis, Sjogren’s syndrome, some systemic connective tissue diseases and vasculitis, as well as in hematology in lymphoproliferative diseases. Administration of rituximab leads to depletion of B-lymphocytes through various mechanisms, including antibody-dependent and complementdependent cytotoxic effects, as well as the regulation of apoptosis. Considering the mechanism of autoimmune damage in Graves’ disease, an autoimmune thyroid disease accompanied by thyrotoxicosis and endocrine ophthalmopathy (an autoimmune lesion of the accessory apparatus of the eye), the use of rituximab may be effective in these diseases. The review considers the currently available results of studies on the use of various doses of rituximab in these diseases.
Frailty in rheumatoid arthritis: prevalence, fenotype signs and associated factors
Authors: Myasoedova S. E. , Amiri E. I. , Utkin I. V.
Published: December 2023

The aim – to establish the frequency of frailty and the ratio of its main phenotypic features in patients with rheumatoid arthritis (RA), as well as to identify associated factors. Material and methods. The study included 101 patients (86 women and 15 men) with RA at the age of 60 [52; 66] years; the average duration of the disease – 8 [3; 15] years. Frailty syndrome was diagnosed by the phenotypic model of L.P. Fried et al. In addition, the strength of the quadriceps femoris muscle was assessed using the test of getting up from a chair, functional status according to HAQ-DI (Health Assessment Questionnaire – Disability Index); Charlson comorbidity index, presence of cardiovascular disease (CVD); dementia severity and nutritional status. Factors associated with frailty were identified by the principal component method with the rotation of the correlation matrix using the Varimax raw method. Results. Frailty syndrome was detected in 40.6%, prefrailty in 55.4% of patients with RA, robust patients were 4.0%. The dominant signs of frailty in RA patients are reduced hand strength, fatigue, and weight loss. Four clusters of factors associated with frailty syndrome in RA have been identified: reduced hand strength, HAQ-DI impairment, and RA activity; reduced survival, comorbid cardiovascular disease and age; the total dose of glucocorticoids (GC) taken, an increase in walking time by 4 m and hypodynamia; eating disorders. Conclusion. Frailty and prefrailty dominate in patients with RA and have certain phenotypic features. Factors associated with frailty and it’s diagnostic features include impairment of vital activity, RA activity; premature mortality, CVD comorbidity, older age; taking GCS and malnutrition.
Course of uveitis in patients with ankylosing spondylitis during the interleukin 17 inhibitors therapy
Authors: Godzenko A. A. , Agafonova E. M. , Dimitreva A. E. , Razumova I. Yu. , Urumova M. M.
Published: December 2023

Background. Biological disease-modifying antirheumatic drugs (bDMARDs) can have different effects on various clinical manifestations of ankylosing spondylitis (AS). Data on the effects of interleukin 17 inhibitors (iIL17) on uveitis in AS continue to accumulate. Objective – to evaluate the effect of iIL17 therapy on the course of uveitis in AS. Material and methods. 73 patients (pts) with AS (New York criteria, 1984), who received iIL17 (57 – secukinumab (SEC), 22 – netakimab (NTK)) for at least 1 year were included in the study. The average age of pts at the time of inclusion in the study was 41.93±8.95 years, the average duration of AS was 10.75±6.22 years. There were 40 (56.7%) men and 33 (43.3%) women among the pts. HLA-B27 was detected in 62/73 (85%), coxitis in 58 (79%), enthesitis in 63 (86.3%), peripheral arthritis in 57 (78%), psoriasis in 7 (9.5%), inflammatory bowel disease (IBD) in 3 (4.1%); in 6 (8.2%) the disease started before the age of 16; 19 (26%) pts had at least 1 episode of uveitis during the course of the disease. The rates of uveitis was estimated by comparing the number of incidences per 100 patient-years before the start of bDMARDs therapy and during iIL17 using. Result. The incidence rate of uveitis before the start of bDMARDs therapy for all pts was 8.3 per 100 pt-years (95% CI: 0.065–0.107), during iIL17 therapy – 9.2 per 100 pt-years (95% CI: 0.06–0.15; p=0.72). The incidence rate of uveitis among pts used SEC was 10.1 per 100 patient-years (95% CI: 0.079–0.13) before the start of bDMARDs therapy, during SEC using – 9.4 per 100 pt-years (95% CI: 0.05–0.15; p=0.74). The incidence rate of uveitis among pts used NTK was 4.8 per 100 pt-years (95% CI: 0.028–0.08) before the start of bDMARDs therapy, during the NTK using – 7.1 per 100 pt-years (95% CI: 0.019–0,22; p=0.3). For patients with a history of uveitis, the incidence rate of uveitis before the start of therapy with bDMARDs was 22.5 per 100 pt-years (95% CI: 0.18–0.28), during iIL17 therapy – 29.1 per 100 pt-years (95% CI: 0.18–0.43; p=0.29). Occurrences of uveitis were observed in 4 of 57 pts (7%) during the using of SEC, and in 1 of 25 pts (4%) – during the NTK therapy. 1 case of new-onset uveitis was recorded during the using of SEC. Conclusion. There were no significant differences in the incidence rates of uveitis during iIL17 using compared with non-biological therapy. iIL17 have not demonstrated a significant effect on the course of uveitis in AS in the study group.
Trabecular bone score, bone mineral density and fracture risk in women with rheumatoid arthritis (pilot study)
Authors: Kozyreva M. V. , Dobrovolskaya O. V. , Demin N. V. , Nikitinskaya O. A. , Toroptsova N. V.
Published: December 2023

The aim – to assess bone mineral density (BMD) and microarchitecture, as well as the risk of fractures in postmenopausal women with rheumatoid arthritis (RA). Materials and methods: 95 postmenopausal women (mean age 62.3±8.1 years) with a confirmed RA were included. All patients underwent a questionnaire, clinical and laboratory examination, dual-energy X-ray absorptiometry (DXA) of the lumbar spine (L1–L4), proximal femur, and trabecular bone score (TBS) assessment. The 10-year probability of osteoporotic fracture was calculated using the FRAX tool without including femoral neck (FN) BMD (BMD–), with FN BMD (BMD +) and additionally adjustment for TBS (BMD + TBS). Results. Osteoporosis (OP) was found in 41 (43.2%) patients: in L1–L4 – in 26,3%, in FN – in 22.1%, and in the total hip (TH) – in 11.6% persons. Degraded microarchitecture according to TBS was found in 38.9% of patients, partially degraded – in 25.3%, and normal – in 35.8% of women with RA. A high risk of fracture according to FRAX BMD– was detected in 49.5% of patients. TBS correlated with age (r=–0.30; p=0.003), duration of postmenopausal period (r=–0.26; p=0.014), cumulative dose of glucocorticoids (GCs) (r=–0.34; p=0.045), FRAX BMD– (r=–0.24; p<0.05) and FRAX BMD+ (r=–0.21; p<0.05); L1–L4 BMD (r=0.43; p<0.001), FN BMD (r=0.21; p=0.038), TH BMD (r=0.23; p=0.02). Low TBS was significantly more often detected in people with a history of fractures compared to people without them (p<0.05). Among RA patients with normal L1–L4 BMD 9.5% of persons had degraded microarchitecture of bone tissue according to TBS. The inclusion of TBS in FRAX increased the risk of fractures to high in 9.5% of patients and reduced it to low in 7.4% of women, due to which the total number of people with RA who had a high risk of fractures became 54.7%. Conclusion. OP was diagnosed in 43.2%, and degraded microarchitecture of bone tissue according to TBS – in 38.9% of postmenopausal women with RA. A high risk of fractures according to FRAX was found in 49.5%. TBS negatively correlated with age, duration of postmenopause, cumulative GCs dose, FRAX fracture risk, and positively correlated with BMD in all measurement sites. The FRAX adjustment by TBS redistributed patients in risk groups, as a result of which 54.7% of RA patients needed anti-osteoporotic treatment.
Necrotic sarcoid granulomatosis – a late stage of nodular sarcoidosis or an independent disease? Analysis of a clinical case
Authors: Galushko E. A. , Pozhidaev E. V. , Radenska-Lopovok S. G. , Gordeev A. V. , Shaligina M. V. , Alekseeva A. V. , Sedelnikova M. A.
Published: December 2023

The aim of this article was an attempt to answer the question: is necrotizing sarcoid granulomatosis a late stage of nodular sarcoidosis or an independent disease? In order to better understand the designated topic, as part of the description of the clinical case, a differential diagnosis of a number of granulomatous diseases with vasculitis was carried out. The main emphasis was placed on the accurate interpretation of pathomorphological features in each individual case.
Entrevista a Eduardo Gudynas
Authors: Mantilla Salgado Jorge David
Published: December 2023

El presente diálogo se desarrolla en función del décimo quinto aniversario de la aprobación de la actual Constitución de la República del Ecuador. Los contenidos de esta carta magna se encuentran asociados con reflexiones, discusiones y cambios de paradigma en materia medioambiental y de desarrollo social. El actual monográfico de la revista Justicia(s) busca ampliar las reflexiones académicas sobre este momento histórico.
First-principles study of structural and electronic properties of ZnSe with wurtzite structure
Authors: Jafarova V.N , Musaev M.A
Published: December 2023

Using Density Functional Theory (DFT) and Local Spin Density Approximation (LSDA) the structural and electronic properties of pure ZnSe wurtzite compound were theoretically investigated. The Hubbard U semiempirical correction has also been used to improve the underestimated DFT calculated band gap. From the DFT+LSDA+U method obtained that the wide of band gap is 2.7 eV and this result is closer to the available experimental results. Current studies reveal that the maximum of valence band and the minimum of conduction band located at the Γ (0, 0, 0) symmetry point on the Brillouin zone. Accurate investigation of the electronic structure of studied material is helpful for the technical applications.
A Review Paper on Air Canvas Application and Text-to-Speech System using Deep Learning
Authors: Dumbre R. S  , Gawade S. G  , Dongare R. P.  , Dr. Khatri A. A  , Dr. Gunjal S. D.
Published: December 2023

Air Handwriting is one of the growing technologies in day by day life. Air handwriting enables user to write in air by using finger movements. The web camera detects the finger movements and converts it into readable format. This will be the natural way of communication with computer system. This will remove the need of physical input devices like keyboard, touchscreen and digital pen. This paper aims to provide an effective platform for both communication and practicing. The existing system has some disadvantages that are overcome in this paper. The existing system requires multiple fingers for writing. But using multiple fingers for different tasks like writing, changing color and erasing is complicated thing to remember. A strong, robust and efficient algorithm is proposed that will extract all the air writing trajectories or curves that are collected using a single web camera. The algorithm avoids restrictions on user’s writing without using a delimiter and an imaginary box. The deep learning CNN algorithms are also used for converting hand written text into user readable text. Additionally, Optimizing algorithms for efficiency can help ensure smooth and responsive performance
EFFECT OF APPLICATION OF STATIC MAGNETIC FIELDS USING THE DOUBLE MAGNET OF MEDICINAL BIOMAGNETISM IN DYSMENORRHEA
Authors: Aparecida Cintra Ana , Januaria Silva Delma , Maria Oliveira Lima Marcia , Viapiana Bossa Adriane , Mara Rambo Martini Angela
Published: December 2023

Introduction: Menstrual colic, or dysmenorrhea, is a common gynecological complaint characterized by pelvic cramp-like pain before or during menstruation. Medicinal Biomagnetism (BM) is a complementary and integrative method that may help in the treatment and prevention of dysmenorrhea symptoms. It aims to restore the energetic balance and ideal pH of the area impacted by medium-intensity therapeutic magnets. Objective: To investigate the effect of the Double BM Magnet on acute menstrual colic pain. Methodology: A case study involving two participants where the Double BM Magnet protocol was applied to address dysmenorrhea, assessed using the Visual Analog Scale. Results: It was observed that the Double BM Magnet tool generated an analgesic effect on menstrual colic pain, providing a significant result within 60 minutes of its application. Conclusion: This study suggests that the application of the Double BM Magnet in the pelvic region for the relief of menstrual pain can have a significant analgesic effect. It proves to be relevant due to its ease of application, non- invasiveness, low cost, and the possibility of self-application. Furthermore, it has minimal contraindications and rare side effects.
As mulheres também foram parte da guerra
Authors: Di Giorgio Florencia
Published: December 2023

presente trabalho busca desenvolver uma análise do processo de “invisibilização” vivenciado pelas mulheres que participaram da Guerra das Malvinas como parte do corpo sanitário argentina. Abordaremos o processo de invisibilização a partir de três níveis (militar, político e social) para entender se realmente foi ou não uma política sistemática de ocultamento. Por sua vez, esse processo é combinado com o silêncio auto atribuído por elas mesmas como uma forma de atravessar as dores da guerra; gerando assim a extensão por tantos anos de seu ocultamento, a dificuldade em abertamente contar suas histórias e de encontrar uma sociedade receptiva a elas. A análise enquadra-se dentro da perspectiva de gênero que há alguns anos tem penetrado cada vez mais na sociedade argentina, para explicar como a partir das mudanças nas percepções da mulher como ator sociopolítico de importância resultou em um impacto positivo no reconhecimento das mulheres que participaram da guerra pelo Estado e pela sociedade civil. Ainda incompleto, esse reconhecimento não penetrou adequadamente na sociedade nem foi abordado de forma abrangente a partir dos grupos decisórios.
Os conflitos ambientais na estação ecológica de Caetés-PE
Authors: Negreiros Emílio de Britto
Published: December 2023

Este trabalho discute os processos que permitiram a constituição de um campo ambiental pela atuação de um movimento em defesa da mata de Caetés, originalmente surgido de bases populares, para evidenciar seus aspectos mais importantes que marcaram a construção socioambiental da mata como uma área protegida, hoje denominada Estação Ecológica de Caetés. Ao mesmo tempo em que se vincula ao movimento ambientalista, é objeto de uma política ambiental de governo que em tese se estruturou para responder às demandas do referido movimento. As dificuldades geradas por pela “ausência” governamental não impediram, todavia, que fossem estabelecidas formas alternativas de gestão que permitissem garantir minimamente a participação comunitária como uma estratégia de defesa e pressão por uma política ambiental na área.
O ENEM e os direitos humanos: Entre os avanços e retrocessos de uma agenda
Authors: Oliveira Amurabi Pereira , Silveira Treicy Giovanella
Published: December 2023

O Exame Nacional do Ensino Médio (Enem) é atualmente a principal prova de acesso ao ensino superior no Brasil, contando desde 2013 com uma regra que estabelecia que redações de candidatos que desrespeitassem os direitos humanos receberiam nota zero. Por meio de decisão judicial, respondendo à ação movida pela associação escola sem partido, essa norma foi retirada em 2017. Neste artigo examino os avanços e retrocessos da questão dos direitos humanos no Enem, apontando que a retirada deste item avaliativo representa um esvaziamento do sentido sociopolítico da escola, que se relaciona a outros retrocessos nas políticas públicas.
O cinema como alegoria para a dinâmica que envolve a subcidadania brasileira
Authors: Piza Suze Oliveira , Pedrosa Tom Menezes
Published: December 2023

O presente artigo utiliza Bacurau, filme dirigido por Juliano Dornelles e Kléber Mendonça Filho, para ilustrar elementos das teorias do sociólogo Jessé Souza, expressos em sua obra Subcidadania brasileira. Neste sentido, pretendemos refletir sobre o pensamento tradicional que entroniza o brasileiro com o título de vira-lata da história, a fim de melhor compreender as assimetrias sociais do Brasil, bem como a relação entre os países modernos e aqueles considerados pré-modernos, que constituem a periferia do sistema capitalista. Ademais, fazendo uma aproximação entre as obras – e nos servindo de referenciais teóricos trazidos por Jessé Souza, como Charles Taylor e Pierre Bourdieu –, buscaremos problematizar questões concernentes ao essencialismo culturalista que edifica uma distinção ontológica entre os indivíduos.
Clássicas Contradições: Simmel e a questão da mulher
Authors: Queiroz João
Published: December 2023

A partir de uma revisão bibliográfica, este trabalho se propõe a ilustrar algumas contribuições e limitações da obra de Georg Simmel em vista de contribuir para o debate acerca da necessidade de se ler criticamente quaisquer autores/as, inclusive os clássicos sociológicos. Sendo assim, este trabalho ocupar-se-á de dois momentos: primeiro, de uma explanação sintética da teoria da cultura simmeliana, e, em seguida, da sua concepção acerca da natureza dos sexos feminino e masculino, evidenciando-se sua inconsistência sociológica e suas incoerências internas com a própria teoria da cultura supracitada.
Análise territorial do Nordeste brasileiro em Manuel Correia de Andrade: um estudo bibliométrico sobre a sua atualidade
Authors: Rocha Gerlane Gomes da , Machado Maria Rita Ivo de Melo , Gomes Rodrigo Dutra
Published: December 2023

O Geógrafo Manuel Correia de Andrade (MCA) desafiou a visão homogênea sobre o Nordeste, tornando-se um pioneiro na geografia crítica brasileira, abordando as relações de produção e de trabalho no espaço agrário nordestino, adotando uma perspectiva dialética, mas sem abandonar elementos marcantes do método regional. Diante desse contexto, o objetivo deste artigo é apresentar  as influências das percepções e temáticas de Manuel Correia de Andrade no debate territorial sobre a região Nordeste na atualidade (2013-2023). A metodologia adotada compreende uma pesquisa bibliométrica que subsidiou a coleta de artigos publicados entre 2013 e 2023 em periódicos nacionais de Geografia, classificados entre os estratos Qualis A1 a A4, sobre a formação territorial do Nordeste. Essa coleta foi realizada por meio de palavras-chave específicas. Dessa forma, buscou-se identificar as possíveis influências de Manuel Correia de Andrade nas discussões atuais sobre a região Nordeste, além de analisar as principais temáticas discutidas e suas correlações com a obra desse geógrafo. Os resultados destacam que os estudos de Andrade permanecem relevantes para a compreensão das questões socioeconômicas e territoriais do Nordeste, especialmente no atual contexto de dinamização das relações de poder nessa região.
University students’ awareness and attitudes regarding environmental responsibility - An ESP perspective
Authors: Rubić Ivana , Pavelić Lucija
Published: December 2023

Drawing on UNESCO's Education for Sustainable Development (ESD) for 2030 Framework, the importance of integrating environmental programs into different disciplines and subject areas at the tertiary education level is highlighted in the paper. The main aim was to investigate whether computer science students’ personal sense of responsibility and concern in regard to protecting the environment have grown over the years due to the availability of information on sustainability issues. Students’ attitudes toward taking a more active role in caring for the environment were examined and the results were compared with those from the previous study conducted in 2017. This earlier study was a part of an ecological approach to language teaching implemented in the professional English course at the University of Applied Sciences Velika Gorica. It is crucial to deepen the culture of ESD. Further, it appears that recent computer science students are better informed of sustainability practices as well as risks in the context of Green Information Technology (IT) area than the previous groups. With regard to that, by using a survey it was investigated if current computer science students’ attitudes toward more active pro-environmental behaviour and thinking were significantly more positive than of those students from the previous study.