bluuebunny/crossref_metadata_2025 huggingface dataset:
The right to truthful information and the freedom of research in the face of new advances in biotechnology: the CRISPR-Cas case of genome editing
Authors: Bernardo-Álvarez Mª Ángela
Published: June 2023

Biotechnology is witnessing a new revolution thanks to CRISPR-Cas, a tool to edit the genome accurately, quickly, easily and economically. This system, which works as a mechanism of adaptive immunity in prokaryotic cells against the attack of viruses, has made it possible to identify pharmacological targets, study the origin of certain conditions or develop animal models of diseases. CRISPR-Cas also has potential health applications, such as its possible use as gene therapy in somatic cells and in the germline. However, genome editing can also involve some risks. The debate about the balance between the benefits and problems of this technology, which can limit the development of certain research activities, should involve society in an inclusive, anticipatory and informed manner. For this it is important to analyse the legal, ethical and social implications of the CRISPR-Cas system from the constitutional perspective of the right to freedom of research and freedom of information, two key elements of democratic countries. La biotecnología asiste a una nueva revolución gracias a CRISPR-Cas, una herramienta para editar el genoma de forma precisa, rápida, sencilla y económica. Este sistema, que sirve como mecanismo de inmunidad adaptativa en células procariotas contra el ataque de virus, ha permitido identificar dianas farmacológicas, estudiar el origen de determinadas afecciones o crear modelos animales de enfermedades. CRISPR-Cas cuenta además con potenciales aplicaciones sanitarias, como su posible uso como terapia génica en células somáticas y en la línea germinal. Sin embargo, la edición genómica también puede entrañar algunos riesgos.El debate sobre el balance entre los beneficios y los problemas de la tecnología, que puede limitar el desarrollo de ciertas investigaciones, debe involucrar a la sociedad de forma inclusiva, anticipatoria e informada. Para ello es importante analizar las implicaciones jurídicas, éticas y sociales del sistema CRISPR-Cas desde la perspectiva constitucional del derecho a la libertad de investigación y a la libertad de información, dos elementos clave de los países democráticos.
Textural properties of ordered nanoporous silica synthesized on mesogenic template
Authors: Kouznetsova T. F. , Kopysh E. A. , Kulbitskaya L. V. , Jumaeva D. J. , Ivanets A. I.
Published: June 2023

Several synthesis routes have been developed and correlations between the variables of the synthesis procedure and the physicochemical properties of nanoporous silica materials of the MCM-48 type deposited by the template method in the presence of a low-valent iron (II) cation have been investigated. Changes in the structure of silica mesoporous framework, its textural properties and the degree of energy inhomogeneity of the surface were studied depending on the Fe/Si molar ratio, pH values (4 and 9 units), stepwise calcination (673 and 923 K) and extraction of cetylpyridinium template with ethanol from xerogels.
Extraction of amitraz and its metabolites with organic solvents
Authors: Polonevich A. G , Leschev S. M. , Bulhakava V. A. , Belysheva L. L.
Published: June 2023

The distribution constants of amitraz and its three main metabolites (DMFF, DMF, DMA) for water–organic solvent (n-hexane, toluene, dichloromethane, chloroform) extraction systems were estimated. Based on the analysis of the substances distribution in the studied systems, it was established that dichloromethane is the optimal choice for amitraz and its metabolites liquid-liquid extraction for method development for their simultaneous determination in honey. Amitraz stability study in water-acetonitrile solutions with various additives demonstrated that 50 mM ammonia solution in water– acetonitrile mixture (1 : 1, vol.) should be used as solvent for the samples final solutions.
Theoretical aspects of the formation of a sustainable fodder base agricultural organizations
Authors: Loban A. G.
Published: June 2023

The formation of a sustainable fodder base of agricultural organizations is one of the key directions of the agrarian policy in the Republic of Belarus. The article considers the essence of theoretical approaches to the study of fodder supply on the basis of their systematization. The structural model of its formation in agricultural organizations is presented and the concept of a stable fodder base with singling out the main problems, problems and factors of its formation is clarified.
Front Matter
Authors: Bengen Dietriech Geoffrey
Published: June 2023

Front Matter
POTENSI DAN MANFAAT EKOSISTEM MANGROVE UNTUK PENGEMBANGAN MATA PENCAHARIAN ALTERNATIF DESA KARANGSONG
Authors: Setyawati Novitria , Imran Zulhamsyah , Yulianto Gatot
Published: June 2023

Pengembangan Mata Pencaharian Alternatif yang berkelanjutan diperlukan untuk melestarikan ekosistem mangrove. Oleh karena itu, penelitian ini bertujuan untuk menentukan jenis mata pencaharian alternatif yang layak untuk dikembangkan. Metode pengumpulan data dilakukan dengan studi pustaka, observasi dan survei serta Participatory Rural Appraisal (PRA). Analisis data menggunakan metode Total Economic Valuation (TEV), analisis tingkat kesejahteraan, analisis kelayakan usaha, analisis SWOT, analisis pola hubungan pemangku kepentingan dan analisis skala penilaian. Hasil penelitian merekomendasikan delapan MPA yang layak untuk dikembangkan di wilayah pesisir Desa Karangsong. Mereka adalah sirup bakau, penyok bakau, kecap, kopi, wedang pantai, dodol, cokelat, dan minuman segar. Kedelapan MPA tersebut menunjukkan adanya kesamaan dalam hal penyediaan bahan baku dan ketersediaan tenaga kerja berdasarkan analisis Rating Scale. Nilai ekonomi total (TEV) menunjukkan bahwa manfaat langsung memiliki nilai ekonomi terbesar dibandingkan dengan manfaat tidak langsung. Hal ini dapat diartikan bahwa manfaat ekonomi dari ekosistem mangrove akan semakin besar jika ekosistem tersebut dapat dipelihara dengan baik, sehingga memberikan manfaat yang berkelanjutan. Hasil penelitian dapat disimpulkan bahwa peningkatan kesejahteraan penduduk Desa Karangsong tidak dapat mengandalkan mata pencaharian mereka saat ini, tetapi perlu mengembangkan delapan MPA secara berkelanjutan untuk meningkatkan kesejahteraan setiap rumah tangga masyarakat pesisir.
COASTAL MANAGEMENT STRATEGIES TO FACE CLIMATE CHANGE AND ANTROPHOGENIC ACTIVITY: A CASE STUDY OF TAMBAN BEACH, MALANG REGENCY, EAST JAVA
Authors: Rudianto Rudianto , Bintoro Gatut , Guntur  , Swatama Deny , Paizar Ariq Rahman , Jeremy Laurentius Klemens , Oktasyah Lutfi , Purba Calvin Arauna
Published: June 2023

This research was set against the backdrop of low levels of coastal ecosystem services at the global, regional, national, and local levels. Changes in land use in coastal areas are mainly caused by an increasing intensity of climate change and irrational land use. The aim of this research was to develop coastal management strategies to deal with intensified climate change and anthropogenic processes. The methods used included using the drone approach to perform a spatial analysis, measuring the parameters of Tamban coastal waters, and applying the Partial Least Squares (PLS) method to determine community assessments and opinions about tsunami. The results of the study indicate that Tamban Beach is highly vulnerable to tsunami hazards even though the water parameters are still on the verge of pollution and that the coastal ecosystem services are not excellent. The results of this study require that the people affected by the tsunami, especially residents on Tamban beach, need to be moved to an area that is safer from the brunt of the tsunami. The area is approximately 10 kilometers from the shoreline. Besides that, this area also needs to be designated as a marine ecotourism area, but free from the tsunami disaster.
Modeling of land use and cover changes (LUCC) in Deli Serdang Regency, North Sumatra Province
Authors: Verawaty Ivong , Widiatmaka  , Firmansyah Irman
Published: June 2023

Land use/cover (LUC) is a substantial factor in land management and can influence policy in an area. LUC has the potential to change due to physical, economic, and social aspects. This study aims to analyze the spatialland use and cover changes (LUCC) in Deli Serdang Regency for the 2010 to 2020 period and predict LUC in 2030. The analysis was run by applying the Cellular Automata-Markov Chain method. The driving factors used in this modeling are the distance to the road, the distance to the river, population density, the distance to the district capital, and the distance to Medan city. The results showed that Kappa for image classification was 0.86. The dominant type of LUC in Deli Serdang Regency is a plantation, with a total area of more than 45%, followed by paddy fields, dryland agriculture, forests, and settlements/built-up areas. LUCC model validation obtained a kappa value of 0.89 (very good category) and can be applicated for predicting land use change models in 2030. By 2030, the settlements/built-up area and dryland agriculture will increase significantly, which 21,060 ha and 4,587 ha, respectively, while forests, plantations, and paddy fields will decrease significantly by around 9,266 ha, respectively, respectively 8,306 ha and 7,806 ha.
The Concept of a Zero Runoff System (ZROS) in reducing the volume of rainwater runoff using infiltration wells at the Syiah Kuala University
Authors: Ramli Ichwana , Mutia Suci , Fachruddin
Published: June 2023

High rainfall with a very high intensity can cause inundation. The purpose of this study was to determine the magnitude of the designed flood discharge that occurred, and the number of infiltration wells needed to reduce rainwater runoff. This research uses data of maximum 10 years of daily rainfall for observation. The results showed that the rainfall intensity for the 5 years return period was 47.24 mm/hr resulting in a design flood discharge of 2.27 m3/second. The average well water level is 5.08 cm with an average soil permeability value of 5.03 cm/hour. Infiltration wells are designed with a depth of 1.5 m with a diameter of 1.4 m. The use of wells is calculated based on 2 types, type 1 (lined well walls) and type 2 (non-lined walls) in each roof class. The total area of roof covering 15.38 ha requires ± 2.678 type 1 wells, or ±2.440 type 2 wells which can reduce rainwater runoff by 17% (type 1) or 30% (type 2) of the total flood discharge of the Syiah Kuala University.
PEMANFAATAN LAHAN KOSONG SEBAGAI PENERAPAN TEKNOLOGI MELALUI KEGIATAN KKN TEMATIK
Authors: Kurniawan Hazen Arrazie , Risnawati Risnawati , Nurhajijah Nurhajijah , Lubis Lubis , Seva Tasya
Published: June 2023

Desa Pemata Johar merupakan salah satu desa tujuan dari kegiatan KKN tematik. Desa ini menjadi tujuan dikarenakan pemerintah desa pematang johar sangat berkonsentrasi dalam pengembangan potensi desa, salah satu potensi desa Pematang Johar yang perlu dikembangkan adalah pemanfaatan lahan kosong milik warga dlaam rangka produksi bahan pangan berupa sayur-sayuran.  Tujuan kegiatan ini adalahuntuk mengoptimalkan lahan sempit yang terbengkalai sebagai lokasi produksi pangan berupa sayuran. Pada kegiatan ini, masyarakat diperkenalkan tentang metode penanaman yang tidak memerlukan lahan luas tapi hasil maksimal dan mudah dimudah dibuat.  Kegiatan dilaksanka dengan pendekatan Partisipatory Rural Appraisal, metode ceramah, demplot dan pendampingan.  Hasil yang dicapai dalam program pembuatan vertikultur ini yaitu, yang awalnya banyak sampah botol bekas berserak tak terpakai sekarang jadi bermanfaat dan berguna dan juga sekarang lahan pekarangan warga jadi lebih bermanfaat guna menambah nilai keindahan desa serta pendapatan ekonomi. Hasil yang dicapai adalah teknologi tepat guna termanfaatkan lahan kosong serta limbah bekas sebagai media penanaman tanaman sayuran. Sayur yang dipanen dapat dijual oleh warga setempat dapat juga dimasak untuk sendiri. Selain itu, waktu panen dari tanaman sayur lebih pendek sehingga warga tidak lama menunggu dari hasil penanam secara vertikultur yang dilakukan dalam kegiatan KKN Tematik.   Berdasarkan kegiatan yang telah dilakukan dapat disimpulkan bahwa ibu PKK dan warga di desa Pematang johar sangat antusias dan ingin memanfaatkan lahan yang kosong untuk budidaya secara vertikultur.  Dengan Kegiatan ini dapat meningkatkan pengetahuan dan keterampilan kepada masyarakat melalui program kegiatan KKN Tematik.
Desperdícios de materiais e tempo: implicações na produtividade
Authors:   , Gois Juraci de
Published: June 2023

Este artigo aborda a questão do desperdício nas empresas. Focando nos desperdícios de tempo e
materiais, analisa suas consequências na produtividade e a importância das tratativas de solução da
questão dentro dos processos produtivos. Tomando como referência o setor de montagem elétrica
de uma empresa fabricante de maquinaria destinada à indústria de produção de latas de conservas e
bebidas, levanta suas dificuldades, ineficiências e prováveis potencialidades latentes. Identificando
as causas dos problemas do setor procura meios de mitigar ou eliminar os seus efeitos. Utilizando
ferramentas da qualidade, propões a implantação de um método largamente utilizado em empresas
do setor de máquinas ou não. Por fim demonstra os resultados, procurando evidenciar os sucessos e
fracassos decorrentes da implantação.
Monitoramento ambiental: metodologias e estudos de casos
Authors: Castro Jonatas da Silva , Sousa Débora Batista Pinheiro , Batista Wanda dos Santos , Costa Jaqueline Custódio da , Souza Samara Silva de , Silva Jhonatan Mota da , Caldas Waldir Heinrichs , Pereira Luiz André Lima , Amanajás Renan Diego , Carvalho Ana Paula Costa , Silva Hallana Cristina Menezes da , Gomes Ana Lúcia Silva , Artoni Roberto Ferreira , Matoso Daniele Aparecida , Lima Ingrid Caroline Moreira , Oliveira Itallo Cristian da Silva de , Sousa Denise da Silva , Rosas Rayane Serra , Couto Natália Jovita Pereira , Pinto Marianne D'Marco Araújo Laranja , Lins Cauã Farias Trindade , Miranda Clidilene Nogueira de Alencar , Santos Débora Martins Silva , Martins Marcos Vinicius Elias , Mendes Girllany Moreira , Luz Carlos Henrique Silva da , Guterres Camila Everton , Eschrique Samara Aranha , Silva Marcelo Henrique Lopes , Lopes Yuri Vinicius de Andrade , Castro Antônio Carlos Leal de , Soares Leonardo Silva , Bandeira Arkley Marques , Azevedo James Werllen de Jesus , Cantanhêde Sildiane Martins , Castro Geane da Silva , Sousa Denise da Silva , Tchaicka Lígia , Bezerra Isabela Cristina Silva , Ribeiro Eliane Braga , Lima Ione Marly Arouche , Sodré Lysandra Caldas , Carvalho Neto Francisco das Chagas Miranda de , Neta Raimunda Nonata Fortes Carvalho , Macedo Gustavo Henrique Rodrigues Vale de , Costa Ana Laíssa Pereira , Ribeiro Rafael do Carmo Silva , Pires Samanda de Jesus Roland , Neulls Talita Fernandes , Toledo Carlos Augusto Barboza , Fontenelle Pedro Henrique Cunha , Cutrim Andrea Christina Gomes de Azevedo , Cutrim Marco Valério Jansen , Sá Ana Karoline Duarte dos Santos , Alves Jálisson de Sousa , Oliveira Ana Virgínia Gomes de , Pinheiro Thiago Ferreira , Batista Raissa Nyra da Silva , Bastos Roberth dos Santos , Matos Lisandra Maria Barroso , Brito Daniel Richard Lemos , Correa Jacyara Nascimento , Torres Thamires Alexandra , Santos Ricardo Luvizotto , Castro Muryllo Santos , Fortes Camilla Victória Coelho , Reis Itala de Cássia Sousa , Carvalho Jonatas Alan Rocha , Jorge Marianna Basso , Costa Taiane Silva , Santos Nágela Gardênia Rodrigues Dos , Privado Débora Carolina Costa , Mota Sarah Afonso
Published: June 2023

O livro “Monitoramento ambiental: Metodologias e Estudos de casos” volume II apresenta novos trabalhos que abordam práticas de monitoramento ambiental em diferentes ecossistemas e utilizando diferentes organismos. Este ebook tem como objetivo alcançar pesquisadores e professores nos diferentes níveis de ensino, auxiliando na discussão da temática em sala de aula.
TECNOLOCIAS SOCIAIS VIRANDO O JOGO DA DESIGUALDADE NO BRASILTECNOLOCIAS SOCIAIS VIRANDO O JOGO DA DESIGUALDADE NO BRASIL
Authors: Gois Juraci de
Published: June 2023

Tendo como objetivo norteador as premissas da tecnologia social, este artigo faz uma abordagem sobre a importância da criação de núcleos de produção artesanal destinados ao consumo turístico, interno e externo, próximos aos centros produtores e em regiões carentes do Brasil. A proposta é unir o conhecimento tradicional e popular acerca do cultivo de pimenta e a produção de derivados à produção de embalagens obtidas através do manuseio de produtos naturais ou reutilizados, que sejam comuns nestes locais. Investigar a possibilidade de criação de núcleos de produção artesanal regional, possibilitando a geração de renda e o resgate cultural das comunidades que serão assistidas pela iniciativa.
METODOLOGIAS ATIVAS DE ENSINO - Aprendizagem Baseada em Problemas no ensino de logística portuária
Authors: Góis Juraci de
Published: June 2023

O ensino tradicional que ora forma os profissionais logísticos, já não atende às necessidades
de conhecimento para gerir as demandas de gerenciamento e controle dos processos logísticos
em portos, notadamente os marítimos. A complexidade dos processos e serviços dos portos
exige uma formação multifacetada e interdisciplinar, onde o profissional deve atuar em
situações que demandam respostas rápidas as mais acertadas possível, a situações nem sempre
conhecidas e gerenciáveis sem um conhecimento especializado multifacetado como assinala
Cruz (2007) em seu trabalho. Objetivando colocar o aluno no centro de aprendizagem
pesquisando a aplicação de metodologias ativas, este trabalho propõe a utilização da
metodologia Aprendizagem Baseada em Problemas como elemento dinamizador de
aprendizagem na disciplina Logística Portuária Marítima utilizando problemas reais e
desafios simulados se apoiando em Freire (1996) quando escreve sobre a educação de adultos.
Propondo um Plano docente voltado à qualidade nos processos logísticos portuários, objetiva
um aprendizado baseado em problemas reais utilizando um método que coloca os alunos
como agentes do aprender, método que pode formar profissionais logísticos com preparo
suficiente para enfrentar os desafios da área portuária marítima, uma vez que esta área de
atuação da logística nacional tem se tornado um dos pontos que mais demandam mão-de-obra
com conhecimentos que mesclam múltiplas especializações profissionais e este método de
ensino tem potencial para auxiliar na formação de profissionais com conhecimentos
interdisciplinares e aptos a lidar com situações adversas e de difícil controle.
Percepciones del paciente oncológico terminal ante intervenciones de enfermería no farmacológicas para el dolor en un hospital público, Bogotá 2021
Authors: Armijos-Pintado Andrés Francisco , García-García Mercedes Adriana , Gómez-Salas Yohana Judith
Published: June 2023

Introducción. El dolor es un síntoma frecuente en el paciente oncológico en fase terminal e impacta todos los aspectos de su vida; en su control el personal de enfermería implementa cuidados farmacológicos y no farmacológicos (masaje, relajación, musicoterapia, entre otros). El objetivo de este estudio fue identificar las percepciones del paciente oncológico en fase terminal frente a las intervenciones de enfermería no farmacológicas para el manejo del dolor en un hospital público de Bogotá en el 2021. Metodología. Estudio cualitativo-fenomenológico; participaron con muestra teórica y muestreo a conveniencia 12 personas, a quienes se les aplicó entrevista semiestructurada, las cuales fueron grabadas, transcritas y analizadas con codificación abierta, axial y selectiva por medio del programa NVivo versión 12. Resultados. Los participantes tuvieron una edad promedio de 67 años y la mayoría fueron hombres (n:8; 67%); las categorías principales de análisis fueron 1) percepción de dolor; 2) conoce técnicas no farmacológicas para el manejo del dolor; 3) conocimiento de las enfermeras frente a las intervenciones no farmacológicas; y 4) experiencias de las técnicas no farmacológicas. Discusión. El paciente oncológico valora y percibe las intervenciones de enfermería no farmacológicas como procedimientos que mejoran su parte física y emocional, permiten que la calidad de vida se mantenga; las prácticas alivian el dolor y lo hace sentir mejor. Conclusiones. Los participantes perciben que, aunque el dolor es fuerte e insoportable, las intervenciones no farmacológicas hacen parte de su proceso en la lucha contra su patología y ayudan a aliviar las molestias.
¿Cómo innovar en cirugía en América Latina? Una propuesta para la evolución del marco IDEAL
Authors: Villarreal-Restrepo Isabella , Cabrera-Vargas Luis Felipe , Villarreal-Viana Ricardo Adolfo , Forero-Ramírez Nicolas
Published: June 2023

Introducción. La innovación ha marcado el progreso de la cirugía por medio del desarrollo y aplicación de procedimientos seguros y rentables enfocados en solucionar los problemas del profesional. Además, ofrece a los usuarios nuevas técnicas y alternativas accesibles y seguras para elegir. División de temas tratados. La innovación en cirugía se basa en: 1) técnicas; 2) mejora en la logística de la práctica; 3) e introducción, diseño de dispositivos y herramientas. El Innovar debe estructurarse basado en marcos propuestos como el Idea, Development, Exploration, Assessment, Long term study (IDEAL). Hay que comprender la necesidad de innovar en cirugía y proponer puntos clave para tener en cuenta durante la implementación del marco IDEAL, herramienta valiosa como propuesta innovadora de cirugía en Latinoamérica. Conclusiones. La innovación es un camino al progreso y avance de la medicina en general. Se propone que para lograr un impacto innovador se centre en la aplicación del algoritmo propuesto, relacionándolo con la realidad que afronta nuestra sociedad Latinoamericana.
Redefiniendo la era de la cirugía digital: el rol de la inteligencia artificial, la realidad aumentada y el aprendizaje automático en el campo quirúrgico
Authors: Barajas-Gamboa Juan Sebastian
Published: June 2023

La era de la cirugía digital se caracteriza por la implementación de nuevas tecnologías que tienen el potencial para el mejoramiento de la planeación prequirúrgica, de incrementar la disponibilidad de alternativas terapéuticas, de mejorar el entrenamiento quirúrgico en aprendices, de optimizar los resultados postoperatorios de los pacientes y a su vez, de reducir posibles eventos adversos. (1) A pesar de que la incorporación de estas tecnologías tiene como premisa principal mejorar los resultados clínicos de los pacientes, el uso de estos avances se ha visto acelerado por intereses comerciales y por las oportunidades que tienen las grandes compañías de generar ganancias a nivel mundial. (2) Entre las tecnologías que en la actualidad están teniendo un impacto directo en al campo quirúrgico se resaltan la inteligencia artificial (IA), la realidad augmentada (RA) y el aprendizaje automatizado (AA) sin dejar a un lado la disponibilidad de dispositivos robóticos de uso cotidiano. (3) A pesar de que la cirugía digital cada vez gana más popularidad en la práctica clínica, en la actualidad aún existe una falta de conocimiento de la misma, de sus beneficios y sus potenciales barreras para su adopción.
Transcendência-Imanência, a difícil dialética da hora presente
Authors: Baraúna Guilherme
Published: June 2023

O cristão de hoje pisa indiscutivelmente em um campo carregado de alta tensão. Convergem para êle, em fluxo e refluxo contínuo, as ondas e os ventos de esperança, de ânsia, de angústia, de inquietação e de dúvida que invadem e sacodem de ponta a ponta esta realidade polivalente que chamamos «mundo». Ondas e ventos que em outros tempos eram inócuos, porquanto não atingiam os moradores de uma cidadela cuidadosamente protegida contra as intempéries e a maré da História ou os membros de uma Igreja que coincidia geográfica, política e sociologicamente com a cidade terrestre...
Immunohistochemical assessment of Cox-2, and ki- 67 expression in gastric cancer
Authors: Bakir Wasan A.
Published: June 2023

Cell proliferation characteristics may reflect the aggressiveness of gastric cancer and their eventual prognosis. The aim of this study was to evaluate whether the proliferative activities determined by Ki-67 labeling index (LI) could be used as a predictor in patients with gastric cancer, and examine the relation between COX-2 and Ki-67 expression and gastric cancer. The expression of COX-2 and Ki-67 were detected in 40 patients with gastric cancer and 30 healthy individuals were assessed by immunohistochemistry. The biopsies were fixed in 10% buffered formaldehyde solution, embedded in paraffin and stained immunohistochemically with anti-human COX-2 and Ki-67 antibodies. Expression of Ki-67 andCOX-2was significantly higher in tumor compared with control samples.A significant correlation was found between COX-2 and Ki-67 protein expression. In conclusion,the expression of COX-2 and Ki-67 proteins was closely connected with gastric cancer.
Optimization of Arginine deiminase production from a local higher productive isolate Enterococcus faecium M1
Authors: Mahdy Nada Z.
Published: June 2023

Arginine deiminase (ADI) is an important enzyme in many biological applications and a cancer treatment agent, recently increasing attention is focused to choose a higher productive strain from different bacterial sources. Eighty nine Enterococcus isolates were obtained from 215 samples (20 clinical UTI specimens, 52 human stool specimens, 6 soil and 11 from sewage water), fifty seven isolates were ADI producer. Twenty five isolates were more active in enzyme production, fourteen of them were identified as E. faecium and 11 isolates were E. faecalis. E. faecium isolate M1 obtained from UTI was the most efficient in ADI production, the specific activity of ADI produced from this isolate was 2.64U/mg protein. The effect of culture medium (Mineral salt broth) components on ADI production and other cultural conditions were determined to find the optimum conditions for enzyme production. The maximum ADI production was achieved when the medium was supplemented with 20mM arginine, 1% sucrose, 1% casein, pH 7.5 and incubated at 37ºC for 18 hours. Under these conditions, the specific activity of ADI was 5.1U/mg protein. By concluding, the present study was designed to select ADI higher productive isolate and optimum culture conditions for increasing the production of this enzyme in order to use it as a potent cancer treatment agent after purifying and characterizing it in the future.
Contribution of parental chromosomal abnormalities to recurrent spontaneous abortion: A cytogenetic study on Iraqi couples
Authors: Jawad Rana S.
Published: June 2023

The main objective of this research study the parental chromosomal abnormalities to recurrent spontaneous abortion Parental chromosomal rearrangements are account for more than 50% of RSA. So, it became necessary in this study to determine whether chromosomal factor is involved in RSA in Iraqi population. Related to that reason, blood samples from couples were collected and chromosomal abnormalities (structural or numerical) were detected by cytogenetic studies. Results from this examination indicated that increased chromosomal abnormalities in couples with advanced age and these abnormalities include translocation and deletion as follows: 46 XY,9qh+ ; 46 XX,21pss ; 46 XY, t(14,15) ; 46XY,14 pstk ; 46 XY ,15 pstk ; 45 XY, 3del. One can expect that, when these abnormalities are transferred to the fetus it can cause disturbance of the chromosomal structure of the fetus which resulted in abortion
Polymorphism of Glutathione-S -Transferase P1 gene in Breast Cancer patients in Baghdad /Iraq
Authors: Muftin Najlaa Qassim
Published: June 2023

Glutathion S-transferase enzymes are detoxifying enzymes – phase II enzymes, which play an important role in protecting cells from damage caused by endogenous and exogenous compounds and subsequently, are crucial in protecting the DNA. The aim of this study is to evaluate polymorphism of Glutathion S-transferase P1 (GSTP1) in Iraqi women breast cancer. Blood samples were collected from 65 Iraqi women diagnosed as breast cancer patients who attended to Oncology Teaching Hospital and Al-Yarmouk Teaching Hospital. In addition to 59 healthy women as control group. Genomic DNA was extracted then genotyping was performed by restriction fragment length polymorphism- polymerase chain reaction (RFLPPCR) for GSTP1 gene. The frequencies of GSTP1 polymorphism (Ile105Val) in the breast cancer group were: 41.54% for wild type (Ile/Ile), 49.23% for heterozygote (Ile/Val) and 9.23% for homozygote mutant (Val/Val), while in control group was 57.63 for wild (Ile/Ile), 42.37(Ile/Val) heterozygote and 0.00 %(Val/Val) homozygote. The results show there were statistically significant differences in the distribution of (Val/Val) genotype and Val allele between patients and controls groups (p<0.05), (OR= 16.3091; 95% CI= 0.8798 to 302.3326) and (OR= 1.9380; 95% CI= 1.0274 to 3.6556) respectively . This study showed that GSTP1 (Val/ Val) genotype may be associated with an increased risk for breast cancer among Iraqi women.
Effect of motor relearning programme on neurological functions and level of disability on upper limb activity in post-stroke patients
Authors: Anmol Narang  , Reena Arora  , Lalit Arora
Published: June 2023

Objective: To compare the effects of Motor Relearning Programme and Mirror Therapy on upper extremity functions in Post-Stroke patients. Design: Parallel group, randomized controlled trial Settings: The present study was conducted at OPD of University College of Physiotherapy, Faridkot, IPD and OPD of Department of Neurology and Neurosurgery of Guru Gobind Singh Medical College and Hospital, Faridkot,Punjab. Participants: A total of 45 post-stroke patients with upper limb impairent were randomly allocated into three equal groups comprises 15 patients each.Group A received Motor Relearning Programme (MRP) along with Conventional Physiotherapy (CPT), whereas Group B received Mirror Therapy (MT) along with CPT and Group C receivedCPT only. The total duration of intervention was 1 hour per session and frequency of 8 weeks, with 5 sessions per week. Main Outcome Measures: The outcome measures included were National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (MRS). Results: The present study revealed that both parameters within the groups had significantly improved in the pre-intervention analysis. However, post-intervention scores of all the parameters of Group A revealed considerable high improvement at a significant level of (p<0.0001) when compared to the other two groups i.e. Group B and Group C. Conclusion: In light of the study's findings, it is concluded that the MRP along with CPT is more effective than MT along with CPT and CPT alone.
Development of novel real-time intranet-based food ordering system
Authors: S. V. Viraktamath  , Raghavendra Kowtal  , Akash Patilkulkarni  , Rachit Alagundagi  , Afreen Baddurkhan
Published: June 2023

In today's fast-paced modern world, individuals often face time constraints that prevent them from spending ample time in the canteen, waiting for their food. To address this issue, an innovative approach is proposed i.e. Intranet-based food ordering system that offers convenience to both students and faculty. This system effectively tackles the drawbacks of the traditional queueing systems. Our proposed solution acts as a user-friendly medium for ordering food effortlessly from the cafeteria it uses technologies like HTML5, CSS3, JavaScript, Node.JS, Maria DB. It revolutionizes the process of taking customer orders. Through the Intranet food ordering system, a comprehensive online menu is made available, enabling customers to conveniently place their desired orders. Furthermore, customers can easily track the status of their orders. Since this system is implemented within a specific area such as campus, the order volume remains moderate, allowing for efficient service. Payments can be made online or through a pay-on-pickup (self-service) approach. To ensure enhanced security during the ordering process, individual user accounts are maintained, with each user being assigned a unique ID and password.
PELATIHAN MANAJEMEN WAKTU PROYEK KONSTRUKSI BERBASIS APLIKASI MICROSOFT PROJECT PADA SISWA SMA/SMK
Authors: Prafitasiwi Avisha Gita , Ayunaning Kholidia , Sutrisno Rahmat Dwi , Alfianidah Rizki , Leowanda Dewa
Published: June 2023

The era of digitalization forces us to create a well-integrated system, thus the use of applications  can facilitate the process of implementing and controlling work. In large-scale construction projects with a lot of project activities in it, it is impossible to control manually, so it will be easier if we use assistive applications such as Microsoft Project. The problem underlying the implementation of this training for SMA/SMK students is the lack of skills of the younger generation in using the application, especially in construction project time management. Application that are usually used in SMA/SMK are usually limited to Microsoft Excel. This service aims to increase the knowledge of students, especially SMK PGRI 1 Gresik students, so they can quickly adapt to the professional world. The presentation method, question and answer, pre-test, post-test and continued with practice are used in this cummunity service. The result of this training is an increase in the target of student knowladge from 55% to 86%.
Probing of Hardships and Their Factors of EFL Students in Constructing Text
Authors: Hasan Jhems Richard , Habibie Alvons , Helingo Adimawati
Published: June 2023

The objective of this study was to investigate students' hardships and their factors in creating descriptive texts. The subject of this study was the fourth semester of IAIN Sultan Amai Gorontalo's English Education Program. 39 students were involved in this study. Three types of instruments were employed to gather the data: documentation, questionnaires, and interviews. The document was used to evaluate students' proficiency in five writing-related areas. The questionnaire was designed to identify specific challenges with descriptive text composition. The purpose of the interview was to identify factors contributing to students' difficulty in writing descriptive texts. This study employed mix method. This study revealed that students had difficulty with content, organization, and mechanics. In terms of content, students struggled with constructing subject sentences (30.76%), supporting sentences (59.97%), and closing sentences (38.46%). Students had trouble repeating essential terms (28.20%), utilizing linking words (28.20%), and explaining the topic (43.58%). In technical, students experienced difficulty with punctuation (12.82%) and capitalization (20.51%). The factors of hardship were self-motivation, self-confidence, lack of reading, and lack of practice were internal issues. External influences included the chance to write, learning materials and media, and the absence of feedback in the teaching and learning process.
POLA PENDIDIKAN PESANTREN PONDOK IT YOGYAKARTA
Authors: Iwan Sopwandin  , Ahmad Hinayatulohi  , Dani Syaripudin
Published: June 2023

Pesatnya perkembangan zaman mengharuskan setiap lembaga pendidikan tak terkecuali pesantren dituntut untuk mampu bersaing dan kompetitif selain dalam hal pengembangan keagamaan tetapi juga sektor tehnologi, untuk mencapai hal tersebut tentunya dibutuhkan pola pendidikan pesantren yang adaptif dan dapat dirasakan oleh semua kalangan masyarakat. Tulisan ini bertujuan untuk menganalisis pola pendidikan yang diterapkan pesantren pondok IT Yogyakarta. Metode penelitian yang digunakan ialah kualitatif. Teknik pengumpulan data melalui observasi, wawancara dan studi dokumentasi. Sedangkan untuk pemilihan informan menggunakan teknik sampling purposive dengan tahapan analisis data meliputi reduksi data, penyajian data dan kesimpulan. Hasil penelitian ini menunjukan bahwa ada tiga pola pendidikan yang diterapkan pesantren Pondok IT Yogyakarta, yaitu: 1) integrasi kemampuan digital dan pemahaman agama; 2) Kakak Asuh Pesantren Pondok IT Yogyakarta dalam pengembangan pesantren; dan 3) Berorientasi pada Santri tidak mampu.
KEPEMIMPINAN TRANSFORMASIONAL KEPALA SEKOLAH DAN EFIKASI DIRI DENGAN KOMPETENSI PROFESIONAL GURU SEKOLAH DASAR DI GUGUS 013 KABUPATEN TANGERANG
Authors: Sulaeman Mohammad , Sudadio Sudadio , Asmawati Luluk
Published: June 2023

ABSTRAK

Penelitian ini bertujuan untuk menganalisis hubungan kepemimpinan transformasional kepala sekolah dan efikasi diri dengan kompetensi profesional guru sekolah dasar di Gugus 013 Kabupaten Tangerang. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan korelasional. Populasi guru dalam penelitian ini berjumlah 146 orang dari 14 sekolah di gugus 013 kecamatan Cisoka Kabupaten Tangerang dan sebanyak 107 orang dijadikan sampel penelitian dengan menggunakan teknik proportionate stratified random sampling. Selanjutnya pengumpulan data penulis menggunakan angket dan analisis yang digunakan adalah korelasi product moment dan korelasi ganda. Hasil penelitian menunjukkan (1) Terdapat hubungan yang positif dan signifikan kepemimpinan transformasional kepala sekolah dengan kompetensi profesional guru dengan nilai koefisien korelasi sebesar 0,597 berada pada tingkat hubungan cukup kuat (2) Terdapat hubungan yang positif dan signifikan efikasi diri dengan kompetensi profesional guru dengan nilai koefisien korelasi sebesar 0,572 berada pada tingkat hubungan cukup kuat (3) Terdapat hubungan yang positif dan signifikan kepemimpinan transformasional kepala sekolah dan efikasi diri secara bersama sama dengan kompetensi profesional dengan nilai koefisien korelasi ganda sebesar 0,604 berada pada tingkat hubungan kuat dan nilai koefisien determinasi sebesar 36,48%.
PERENCANAAN PENGADAAN BAHAN PUSTAKA DI SMA NEGERI 4 KARAWANG
Authors: Sayan Suryana  , Ferianto
Published: June 2023

This study aims to describe the planning for procurement of library materials in the Karawang 4 Public High School library and what are the factors that influence it. Researchers used descriptive qualitative research. In this study, the information in this study was the head of the library, librarians and users. The data collection techniques in this study were through observation, interviews and documentation. The data analysis technique of this research uses Miles and Huberman analysis which divides the analysis into data collection, data reduction, data display and conclusion drawing, verification. The results of this study indicate that the planning process for procuring library materials begins with determining the budget, then selecting library materials up to the purchasing process, the methods used in procuring library materials at SMA Negeri 4 Karawang are, 1) Purchases, 2) Gifts, and 3) donations . The supporting factors for planning the procurement of library materials in the SMA Negeri 4 Karawang library are, 1) There is assistance from outside parties, both agencies or individuals who contribute in the form of books to add to the collection of library materials, and 2) The planning system for procuring library materials is already going well . While the inhibiting factors are 1) Lack of competence of managers in properly managing the procurement of library materials.

Keywords: Planning, Procurement, Library Materials
PENINGKATAN KASUS PERCERAIAN APARATUR SIPIL NEGARA DI LINGKUNGAN PEMERINTAH KOTA SOLOK
Authors: Mulanda Dana , Frinaldi Aldri
Published: June 2023

Peraturan Pemerintah Nomor 45 Tahun 1990, yang mengubah Peraturan Pemerintah Nomor 10 Tahun 1983 tentang Izin Perkawinan dan Perceraian bagi Aparatur Sipil Negara, mengatur perkawinan dan perceraian bagi Aparatur Sipil Negara (ASN). Syarat, tahapan, dan akibat perceraian bagi ASN diatur secara ketat oleh peraturan tersebut. Pemotongan tunjangan berbasis gaji adalah salah satu akibat dari perceraian terencana. Angka perceraian ASN Pemkot Solok naik pada 2022 dibanding tahun sebelumnya, sebanyak enam kasus. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana Pemerintah Kota Solok telah mengimplementasikan Peraturan Tata Usaha Negara Nomor 45 Tahun 1990 dan Peraturan Pemerintah Nomor 10 Tahun 1983 tentang izin nikah dan cerai bagi pegawai negeri sipil negara. Penelitian ini mengkaji masalah dan cara pandang terhadap gagasan dan perilaku dalam kehidupan sosial dengan menggunakan desain penelitian deskriptif dengan metodologi kualitatif. Dalam penelitian ini terdapat berbagai tahapan dalam proses pengolahan data, antara lain pengumpulan data, reduksi data, penyimpanan data, dan verifikasi data. Temuan penelitian ini menunjukkan bahwa proses perceraian ASN di Kota Solok telah sesuai dengan semua undang-undang yang relevan. Setiap tahun terjadi perceraian ASN di lingkungan Kota Solok, tahun 2019 menjadi tahun yang paling banyak terjadi. Pasalnya, ASN bercerai di Kota Solok.
Faktor yang MempengaruhiPerkembangan Nilai Agama Moral pada Anak Usia Dini
Authors: Susetya Pratitis Dyah , Zulkarnaen Zulkarnaen
Published: June 2023

Tujuan artikel ini adalah menganalisis faktor apa saja yang mempengaruhi perkembangan nilai agama dan moral anak usia dini. Penelitian ini merupakan penelitian kualitatifdengan desain literatur review, sumber data  yang digunakan merupakan sumber dari literatur yang berkaitan dengan perkembangan moral anak usia dini, yakni berupa artikel-artikel jurnal ilmiah serta buku-buku. Analisis datanya adalah analisis deskriptif, dari hasil analisis disimpulkan bahwa tiga factor utama yang mempengaruhi perkembangan nilai moral dan agama anak usia dini yaitu orang tua dengan penerapan pola asuh yang baik, guru dengan penggunaan metode dan media pembelajaran yang sesuai dengan perkembangan anak dan lingkungan termasuk lingkungan sekolah dan keadaan situasi lingkungan, konteks individu atau kepribadian, dan konteks sosial atau cara berintraksi dengan lingkungan sekitar dalam bermasyarakat.
Keterlibatan Pendidik dan Tenaga Kependidikan Laki-laki dalam Sistem dan Layanan Pendidikan Bagi Anak Usia Dini di Kota Salatiga dan Sekitarnya
Authors: Andika Dian Maya , Widiastuti Ajeng Ayu
Published: June 2023

Penelitian ini bertujuan untuk mengetahui hal-hal yang berkaitan dengan keterlibatan pendidik dan/atautenaga kependidikan laki-laki dalam memberikan layanan pendidikan bagi Anak Usia Dini di lembagaPAUD yang ada di Kota Salatiga dan sekitranya. Hadirnya sosok pendidik laki-laki dalam sistempendidikan anak usia dini akan berpengaruh terhadap pola dan sistem pendidikan itu sendiri serta fungsipengasuhan yang melibatkan sosok ayah. Meski masih diselimuti tantangan, namum hadirnya sosokpendidik laki-laki dapat merefleksikan bagaimana hierarki masyarakat sosial harus mendekonstruksiulang tatanan sosial masyarakat sosial yang adil gender. Lokasi dalam penelitian ini adalah lembagaPendidikan Anak Usia Dini di Kota Salatiga dan sekitarnya. Penelitian menggunakan pendekatankualitatif dengan metode studi kasus. Pengumpulan data dilakukan dengan teknik observasi, wawancaramendalam dan dokumentasi. Analisis data menggunakan Miles Huberman melalui tahapan reduksi data,penyajian data, verifikasi dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa para pendidikdan/atau tenaga kependidikan laki-laki di lembaga PAUD memiliki peran dalam proses penyelenggaraanpendidikan seperti pada kegiatan pembelajaran, administrasi dan juga majaerial lembaga. Hadirnya parapendidik dan/atau tenaga kependidikan di PAUD yang terdapat di Kota Salatiga dan sekitarnya diterimasecara positif oleh rekan pendidik dan/atau tenaga kependidikan lain , orang tua peserta didik dan jugamasyarakat secara luas.
Performance of Asphalt Wearing Course Against The Immersion Effect Of Tide Water (Rob) With Added Materials Polyethylene And Fine Aggregate Slag
Authors: Sulistyo Juny Andry , Pratikso P , Mudiyono Rachmat
Published: June 2023

Rob or tide water is a flood of seawater or rising sea level caused by high tide inundating land. Heavy traffic and tidal immersion on main roads result in permanent deformation require quality asphalt that is resistant to tidal immersion and traffic loads. The use of a combination of LDPE and aggregate slag is an unprecedented update. Polyethylene (PE) plastic waste provides water resistance therefore the combination can be a new Job Mix Formula that is able to withstand tidal immersion (rob) allowing it to be used in the construction of road structures (Flexible Pavement). The duration of immersion is 7 days, 14 days and 21 days and the soaking method consists of immerse with a continuous pattern and soaking with a periodic / cyclic pattern (intermittent). Job Mix Formula that can be used on asphalt concrete wearing course modification is a combination of 50% Slag aggregate and 6% LDPE while asphalt concrete wearing course modification of 0% and 100% Slag Aggregate grades with LDPE 0%, 2%, 4%, 8%, 10% and 18% cannot be used as road pavement because it does not meet the requirements of Bina Marga technical specifications.
Paikallisia ruokajärjestelmiä kehitetään nyt vahvemman talouden ja turvallisuuden toivossa
Authors: Puupponen Antti
Published: June 2023

Paikallisen toiminnan merkitystä on perusteltu vuosien saatossa monin eri tavoin. Tunnetulla sanonnalla ”Think global, act local” on pitkät juuret paitsi ympäristöajattelussa niin myös liiketaloudessa ja yritysviestinnässä. Sanonta liittyy myös ruokaan. Sillä on voitu perustella esimerkiksi reilun kaupan tuotteiden ostamista. Toisaalta paikallisen toiminnan korostaminen sopii myös lähiruokaan.
Kirjoitin Alue ja Ympäristö -lehteen vuonna 2008 artikkelin Elintarviketuotannon paikallinen kehittäminen Keski-Suomessa. Artikkelissa tarkastelin juuri ruoan paikallisuutta, lähiruokaa ja sitä, minkälaista kehittämistyötä suomalaisilla maatiloilla tehdään erilaisten projektien kautta lähiruoan edistämiseksi. Artikkeli perustui 15 keskisuomalaisen maaseudun kehittäjän teemahaastatteluihin. Maatiloilla näytti olevan kehitystarvetta juuri pieninä paikallisina toimijoina, sillä ruokajärjestelmää tuntuivat hallitsevan suuret kauppaketjut ja globaalin talouden toimintalogiikka. Artikkelissa päädyin kahteen keskeiseen johtopäätökseen siitä, mitä tiloilla tulisi tehdä, jotta paikallinen tuotanto voisi vallinneessa tilanteessa kehittyä. Nämä olivat verkostojen rakentaminen ja tuotannossa erikoistuminen...
PENINGKATAN LITERASI SAINS MELALUI PENGEMBANGAN MEDIA BIG BOOK
Authors: Ikbal Ikbal
Published: June 2023

This research is a level 3 research and development (RD) which aims to develop existing products. The product developed is the big book learning media which is then used as a means to improve the literacy science of students at MIN Bone. This research adopts Borg and Gall development research steps which include research and information gathering, planning, initial product development, conducting initial testing by media/design experts, material/content experts and learning practitioners, product revisions, conducting field trials, revisions the final product. There are three data collection techniques used in this study, namely validation carried out by the validator, effectiveness obtained through increasing literacy science and student responses to learning media. The results of the big book media validity test conducted by media/design experts are 85% with good qualifications, material/content experts are 91% with very good qualifications and learning practitioners are 91% with very good qualifications. The effectiveness of the big book media in improving literacy science. through the N-Gain 32 test which got a score of (g) 0.7 as many as 2  students, a value of 0.7 (g) 0.3 as many as 31 students, a value of (g) 0 ,3 as many as 2  students. The student response to the attractiveness of the big book media is 91% with very good qualifications.