bluuebunny/crossref_metadata_2025 huggingface dataset:
Conversion of gravitational and electromagnetic waves without any external background field
Authors: Mishima Takashi , Tomizawa Shinya
Published: February 2023

Applying a simple harmonic map method to the cylindrically symmetric Einstein-Maxwell system, we obtain exact solutions representing strong nonlinear interaction between gravitational waves and electromagnetic waves in the case without any background field. As an interesting fact, we can show that with adjusted parameters the solution represents occurrences of large conversion phenomena in the intense region of fields near the cylindrically symmetric axis.
PACS numbers: 04.20.Jb, 04.30.-w
Immune-related transcripts, microbiota and vector competence differ in dengue-infected geographically distinct Aedes aegypti populations
Authors: Chen Tse-Yu , Bozic Jovana , Mathias Derrick , Smartt Chelsea
Published: February 2023

Background
Vector competence in Aedes aegypti is influenced by various factors and, by recognizing what affects virus and mosquito interactions, crucial new control methods can be developed.
Methods
Here we used three geographically distinct Ae. aegypti populations and compared their susceptibility to infection by dengue virus (DENV). To identify the population differences, we screened immune-related genes and microbiota which might contribute to the uniqueness in competency.
Results
Based on the results from the DENV competence study, we assigned a refractory population (Vilas do Atlântico), a susceptible population (Vero), and a susceptible but low transmission population (California). The immune-related transcripts were highly expressed in the California population but not in the refractory population. However, the Rel-1 gene upregulated after blood-feeding in the Vilas do Atlântico population suggesting involvement in non-viral responses, such as response to microbiota. The bacteria, fungi, and flaviviruses screening showed differences between populations and could be one of the factors that interfere with the vector competence.
Conclusions
All in all, we revealed the potential factors that might impact the virus and mosquito interaction, moreover, influencing the Aedes aegypti refractory phenotype.
Prediction of the Demand Response Behavior of Residential Consumers through a Bayesian Forecasting Method
Authors: Kaheh Zohreh , Arasteh Hamidreza
Published: February 2023

Demand-side resources have been recognized as a cost-effective approach for providing the required flexibility in power systems with high penetrations of renewable resources. Almost all existing demand response (DR) models are established based on the assumption that end-users are always rational and predictable agents with well-defined preferences. This assumption has resulted in apparently unaccountable divergence between modelled and observed results for DR approaches. However, due to the nature of the prompt responses of DR providers to DR signals, it is of paramount importance to consider the effect of impulsive decisions on providing the flexibility. This paper investigates the effects of impulsive decisions on the frequency of being unresponsive to DR signals and the collaboration rate in 5-minutes ahead DRX through a Bayesian Forecasting Method. The analyses have demonstrated considering the provided flexibility in similar days of week as explanatory variable in Bayesian structural time series can be helpful for the detection of impulsive behavior to attain more accurate DR behavior forecasting.
Organizações e disputas por territórios no comércio ambulante do metrô de Recife
Authors: Soares Ribeiro Rafael , Augusto Souto Maior Fontes Breno
Published: February 2023

O presente artigo objetiva discutir a organização e disputas por território no comércio ambulante praticado no sistema metroviário do Recife (METROREC). Estes atores organizam uma configuração peculiar na ocupação deste território. Os dados obtidos para a análise são resultados de uma pesquisa de campo realizada durante 7 meses no ano de 2019 com os ambulantes que atuam no sistema metroviário do Recife. Nesta pesquisa foram usados os métodos de coleta de dados através de observação total, observação participante, entrevistas individuais e grupo focal com comerciantes. Os locais escolhidos para a pesquisa foram as estações de metrô que possuem os maiores fluxos de passageiros e de ambulantes em todos os horários do dia. Daremos destaque neste artigo ao conceito de território, bastante discutido e de considerável importância para diversos campos do conhecimento. Com o destaque na abordagem sócio simbólica deste conceito, tendo por pano de fundo a ideia de sociabilidades e práticas de construção de identidades, em um recorte simmeliano. Consideramos que a ideia de território seja bastante útil à compreensão político-existencial das trajetórias das pessoas, na medida em que fornecem às pessoas as referências para a construção de suas identidades.
Posłanie Syna w ujęciu św. Tomasza z Akwinu
Authors: Ćwik Karolina
Published: February 2023

Św. Tomasz z Akwinu pisząc o posłaniu Syna wpisuje je w szerszy kontekst nauki o wcieleniu. Posłanie rozumie on dwojako: jako posłanie niewidzialne oraz to widzialne.

O posłaniu niewidzialnym mówimy wtedy, gdy w duszy osoby będącej w łasce uświęcającej przebywa Bóg. Oddziałuje On na nasz intelekt – możemy poznać Boga oraz na naszą wolę – jesteśmy w stanie Go miłować. Akwinata podkreśla, że w Trójcy mówimy o jedności istoty, ale o odrębności Osób, dlatego też posłanie Syna różni się od posłania Ducha Świętego. Posłannictwo niewidzialne związane jest z życiem sakramentalnym, które prowadzi do pełnego umiłowania Boga i wzrastania człowieka w doskonałości.

Posłanie widzialne w ujęciu Akwinaty jest związane z wcieleniem Boga. Druga Osoba Trójcy Świętej została posłana, aby zbawić ludzi od grzechu, ukazując swoją nieograniczoną miłość do człowieka. Wcielenie ukazało, że świętość oraz życie wieczne powinno być celem człowieka, a wszystkie nasze myśli powinny być kierowane do Boga.
Ograniczenie własności nieruchomości naruszeniem godności właściciela
Authors: Karpacka Katarzyna
Published: February 2023

Wychodząc z założenia, że godność człowieka stanowi aksjologiczną podstawę wszelkich praw i jest naczelną wartością konstytucyjnego katalogu praw i wolności, bytem niezaprzeczalnym,

niezbywalnym, opracowanie dowodzi, że w rzeczywistości, w świetle aktualnych przepisów, ustawodawca w różny sposób rozumie i chroni godność podmiotów prawa. Jest to szczególnie widoczne w relacjach lokatora i właściciela nieruchomości. Dysproporcja w tym zakresie powoduje, że prawo nie zawsze wyraża takie wartości jak sprawiedliwość, dobro i równość. Przepisy, zawężając granice prawa własności, wpływają na możliwość pełnego korzystania z rzeczy przez właściciela lokalu. Jednocześnie chronią lokatora tylko w określonych sytuacjach, przy użyciu minimalnych środków ochrony, bez realizacji kompleksowej polityki mieszkaniowej, która spełniłaby potrzeby mieszkaniowe osób, które nie są w stanie zaspokoić ich samodzielnie. Ten konflikt praw i godności utrzymuje się od wielu lat, dodatkowo pogłębiany kolejnymi nowelizacjami przepisów. W konsekwencji prowadzi to wielu bezprawnych sytuacji, które bezpośrednio naruszają godność obu stron.
Preliminary Study of the Distinctive Mechanism of Shenqi Compound in
Treating Rats with Type 2 Diabetes Mellitus by Comparing with Metformin
Authors: Fu Xiaoxu , Zhou Xiujuan , Liu Ya , Lei Yuanhong , Xie Hongyan , Leng Yulin , Gao Hong , Xie Chunguang
Published: February 2023

Background:

In China, traditional Chinese medicine (TCM) has been used to treat type 2
diabetes mellitus (T2DM) for centuries.

Methods:

To investigate how the TCM ShenQi (SQC) formulation differs from metformin, four rat
groups, including control, model, T2DM rats treated using SQC (SQC group), and T2DM rats treated
using metformin (Met group), were constructed. The differentially expressed genes (DEGs) between
SQC and metformin groups were screened, and the co-expression modules of the DEGs were constructed
based on the weighted correlation network analysis (WGCNA) method. The correlation between
modules and metabolic pathways was also calculated. The potential gene targets of SQC were obtained
via the TCM systems pharmacology analysis.

Results:

A total of 962 DEGs between SQC and Met groups were screened, and these DEGs were significantly
enriched in various functions, such as sensory perception of the chemical stimulus, NADH
dehydrogenase (ubiquinone) activity, and positive regulation of the fatty acid metabolic process. In
addition, seven co-expression modules were constructed after the redundancy-reduced process. Four of
these modules involved specific activated or inhibited metabolic pathways. Moreover, 334 effective
ingredients of SQC herbs were collected, and four genes (RNASE1 (ribonuclease A family member 1,
pancreatic), ADRB1 (adrenoceptor beta 1), PPIF (peptidylprolyl isomerase F), and ALDH1B1 (aldehyde
dehydrogenase 1 family member B1)) were identified as potential targets of SQC.

Conclusion:

Comparing SQC with metformin to treat T2DM rats revealed several potential gene targets.
These genes provide clues for elucidating the therapeutic mechanisms of SQC.
Evolution of Probiotic Usage in the Global Food Industry: A Comprehensive
Review
Authors: Jayasekara Gammadde Hewa Hishara , Jayasinghe Madhura , Jayasinghe Jagath
Published: February 2023

Food fermentation is one of the oldest food preservation and processing methods that
uses live microorganisms and dates back thousands of years in human civilization. From those
days, human society has used them without knowing the true value of these live microorganisms.
But later, they understood the beneficial health effects of some organisms used in fermentation.
Later they were named probiotics. With the advancement of science, the taxonomic and morphological
details of probiotic bacteria and fungi were identified. In the early stage of human civilization,
probiotics were used only for the preservation of excess food stuff, but now they have
been used for many other aspects. Encapsulated probiotics and dried probiotics enhance the benefits
of probiotics while reducing the major drawback of survivability in harsh conditions. Genetically
engineered probiotics organisms open new avenues in the nutraceutical industry, having
maximum benefits to the host. In modern medicine, probiotic functional foods have been used as
nutraceuticals for multi-drug resisting organisms and as transport vectors. In the near future, Super
probiotic organisms will be the new step in human civilization in terms of food and therapeutic
medicine.
Anthropomorphic Carotid Artery Phantom for Ultrasound Flow and
Vessel Wall Elastography Imaging
Authors: Almutairi Fahad F. , Alyami Jaber H.
Published: February 2023

Objective:

Shear wave elastography imaging (SWE) is a non-invasive US technique that has
been developed to provide quantitative information about tissue elasticity. This technique might be
useful in the identification of vascular risk factors. Arterial wall thickness and inner diameter vary with
age and disease, which may impact shear wave propagation. The effect of arterial geometry on SWE
has not yet been thoroughly investigated. Therefore, this study aimed to investigate the impact of different
wall thickness, pulsation and imaging planes on YM estimates, to gain more information about
the source of variability associated with SWE.

Methods:

Poly(vinyl alcohol) cryogel (PVA-c) fabrication has been used for phantom design and construction.
The agar-based TMM was used to surround the tubes. The inlet and outlet of the phantom
were connected to a programmable gear pump using c-flex tubing to form a closed loop. Image J profiling
was used to clarify the anomalies further detected using SWE.

Results:

The 4 F/T cycle vessel phantom has shown less YM variability than in the 6 F/T cycle. YM
ranged from 8 kPa for a 1 mm thickness tube to 53 kPa for the thickest 6 mm wall thickness for the
softer 4 F/T cycle tube. Vessel phantoms embedded in TMM show higher variability than vessel phantoms
submerged in water. YM ranged from 32 kPa for a 1 mm thickness tube to 117 kPa for the thickest
6 mm wall thickness for the softer 4 F/T cycle tube.

Conclusion:

SWE variability in measurements was higher in phantoms embedded in TMM compared
to those submerged in water. It is recommended that combine the transverse and longitudinal imaging
planes to provide a better understanding of disease over the full vessel circumference.
Development and Implementation of the Hdc.DrApp.la and SIMDA Programs to Reduce Polypharmacy and Drug-drug Interactions in Patients Hospitalized in Internal Medicine
Authors: Barcia Ricardo Enrique , Keller Guillermo Alberto , Azzato Francisco , Diez Roberto Alejandro , Sielecki Mathias , Kleine Ricardo Samson , Lescano Juan Alberto , Giunti Guido
Published: February 2023

Objectives:

We evaluated polypharmacy and possible drug-drug interactions (p-DDIs) in hospitalized patients before and after using the SIMDA Computerized Medical Decision Support System (CMDSS).

Materials and Methods:

We included the prescriptions of ≥ 18 years hospitalized patients in the internal medicine department. We developed and implemented the Hdc.DrApp Physician Order Entry System and the CMDSS SIMDA, which detects p-DDIs and signals dosage adjustment based on renal function. To evaluate the impact of the CMDSS, we made a comparison Before (Survey) / After (Intervention): Survey between Oct/22/2019, and Mar/21/2020, and Intervention between Apr/4/2020 and Sep/3/2020. We analyze prescriptions from the first day and after the first day. We compared the number of drugs, polypharmacy (≥ 5 drugs), excessive polypharmacy (≥ 10 drugs), and p-DDIs. We evaluated differences with the X2 test, Yates correction, Fisher's exact test, ANOVA, and post hoc tests according to their characteristics.

Results:

We evaluated 2,834 admissions: Survey 1,211 and Intervention 1,623. The number of drugs per patient was 6.02 (± 3.20) in Survey and 5.17 (± 3.22) in Intervention (p < 0.001) on the first day and 9.68 (± 5.60) in Survey and 7.22 (± 4.93) in Intervention (p < 0.001) throughout the hospitalization. Polypharmacy was present in 64% of the Survey and 53% of Interventions (RR: 0.83 (0.78-0.88); and excessive polypharmacy in 14% of the Survey and 10% of Intervention (RR: 0.73, 0.60-0.90). The frequency of total p-DDIs was 1.91/patient (± 4.11) in Survey and 0.35 (± 0.81) in the Intervention (p < 0.001).

Conclusion:

We developed and implemented the Hdc.DrApp and SIMDA systems that were easy to use and allowed us to quantify and reduce polypharmacy and p-DDIs.
Strengthening the One Health Approach in the Eastern Mediterranean Region
Authors: Hailat Ekhlas , Amiri Mirwais , Debnath Nitish , Rahman Mahmudur , Nurul Islam Md , Fatima Zahida , Khader Yousef , Al Nsour Mohannad
Published: February 2023

One Health aims to use a multidisciplinary approach to combat health threats at animal, human, and environmental health interfaces. Among its broad focus areas are issues related to food safety, the control of zoonoses, laboratory services, neglected tropical diseases, environmental health, biosafety and biosecurity, and combatting antimicrobial resistance. A roundtable session was conducted on November 18, 2021, as part of the Eastern Mediterranean Public Health Network's (EMPHNET) seventh regional conference to highlight what role Global Health Development (GHD)|EMPHNET can play to strengthen the One Health approach. This viewpoint summarizes the findings of the roundtable discussion to highlight the experts’ viewpoints on strengthening the One Health approach, including the extent of zoonotic diseases and the dynamics of pathogens and emerging diseases; the occurrence of antimicrobial-resistant pathogens as a silent pandemic; issues surrounding the globalization of trade and food safety; the importance of integrated solutions as a new norm; issues around the institutionalization and governance toward effective operationalization of the One Health approach in the region; and how the One Health approach can be operationalized at global, regional, and local levels. The panel concluded that One Health is an integrated unifying approach that aims to sustainably balance and optimize the health of people, animals, and ecosystems, and provided recommendations to strengthen the One Health approach. It also discussed how GHD|EMPHNET can play its role in transferring the concept of One Health from theory to practice via a solid operationalization road map guide at the Eastern Mediterranean region level. The five broad priority areas of this operational guide include (1) establishing and strengthening a governance architecture, legal framework, and policy and advocacy structure for One Health operationalization in the region; (2) fostering coordination, communication, and collaboration for One Health actions across the region and beyond; (3) building the workforce capacity for effective One Health operationalization in the region; (4) supporting regional platforms for timely, effective, and efficient data sharing and exchange on all One Health–related issues; and (5) supporting risk communication, behavior change communication, and community engagement efforts in the region.
Adherence to Patient-Reported Symptom Monitoring and Subsequent Clinical Interventions for Patients With Multiple Myeloma in Outpatient Care: Longitudinal Observational Study (Preprint)
Authors: Lehmann Jens , de Ligt Kelly M , Tipelius Stefanie , Giesinger Johannes M , Sztankay Monika , Voigt Sandra , van de Poll-Franse Lonneke V , Rumpold Gerhard , Weger Roman , Willenbacher Ella , Willenbacher Wolfgang , Holzner Bernhard
Published: February 2023

BACKGROUND

The use of software to monitor patient-reported outcome measures (PROMs) can improve outcomes for patients with cancer receiving anticancer therapy; however, evidence from applications used in routine clinical practice is lacking.

OBJECTIVE

We aimed to investigate adherence to and patient perceptions of a weekly, web-based PROM symptom monitoring program in routine clinical practice for patients with Multiple Myeloma. Moreover, we aimed to capture how clinical alerts prompted by the system influenced clinical care.

METHODS

We conducted a single-center longitudinal observational study to evaluate patient adherence to and perceptions of the PROM monitoring software in routine practice. Patients with Multiple Myeloma remotely completed weekly treatment-specific PROMs to monitor key symptoms via a dedicated web-based platform. Alarming symptoms triggered clinical alerts in the application for the treatment team, which could initiate clinical interventions. The primary outcomes were the web-based assessment completion rate and patients’ perceptions of the monitoring program, as assessed by an evaluation questionnaire. Moreover, clinical alerts prompted by the system and consequential clinical interventions were analyzed.

RESULTS

Between July 2021 and June 2022, a total of 55 patients were approached for participation; 39 patients participated (24, 61% male, mean age 63.2, SD 9.2 years). The median assessment completion rate out of all weekly scheduled assessments was 70.3% (IQR 41.2%-89.6%). Most patients (77%) felt that the health care team was better informed about their health status due to the web-based assessments. Clinical alerts were triggered for 1758 of 14,639 (12%) reported symptoms. For 548 of 1758 (31.2%) alerts, the symptom had been registered before and no further action was required; for 348 of 1758 (19.9%) alerts, telephone consultation and self-management advice sufficed. Higher-level interventions were seldom needed in response to alerts: referral to a doctor or specialist (88/1758, 5% alerts), medication changes (22/1758, 1.3%), scheduling additional diagnostics (9/1758, 0.5%), or unplanned emergency visits (7/1758, 0.4%). Most patients (55%) reported the calls in response to alerts gave them “quite a bit” or “very much” of an added feeling of security during therapy.

CONCLUSIONS

Our study shows that high adherence to regular and tailored PROM monitoring can be achieved in routine clinical care. The findings provide valuable insight into how the PROM monitoring program and the clinical alerts and resulting interventions shaped clinical practice.

CLINICALTRIAL

ClinicalTrials.gov NCT05036863; https://clinicaltrials.gov/study/NCT05036863
Determining Factors of Peer-to-Peer (P2P) Lending Avoidance: Empirical Evidence from Indonesia
Authors: Ali Syaiful , Simboh Billy , Rahmawati Ulfa
Published: February 2023

P2P lending offers loans to the public with easy processes and terms. However, the level of P2P lending disbursements is still lower than that of the banks. In addition, a comparison of the number of users of P2P lenders and the productive age population of Indonesia shows that there are still many people who do not use P2P lending. This paper examines the factors that make Indonesians avoid P2P lending. This study used an online survey approach for its data collection and structural equation modeling (SEM) to analyze the data from 499 responses. The study found that the perceived threat from P2P lending is influenced by its perceived severity, perceived susceptibility, and risk tolerance. This perceived threat and social influences cause people’s avoidance motivation. This study contributes to the fintech literature by providing empirical evidence on the avoidance of P2P lending from the borrowers’ perspectives using the TTAT model. Other implications are an input for regulators/governments to enforce the rules for user protection and input for the P2P lending service providers to provide educational programs regarding the use of P2P lending.
Blue Economy, Blue Growth, Social Equity and Small-scale Fisheries: A Global and National Level Review
Authors: Das Jewel
Published: February 2023

One of the most promising economic arenas in the coming decades is the ocean and there are currently numerous initiatives to the ‘blue economy’ discourse that revolves around the argument that small-scale fishers’ livelihoods require greater attention. To synthesize current scientific knowledge and address prevailing research gaps surrounding this discourse, I conduct a scoping review of global literature on the blue economy, blue growth, social equity, and Small-Scale Fisheries (SSF) analyse different international policy papers and national-level blue economy plans. To explore the need for further research, this review focuses on how different aspects of the blue economy risks lead to inequity in the pursuit of ocean sustainability. Based on the initial content analysis, I identify evidence for undermining social equity and justice related to the ocean and find that social equity is often overlooked in national-level blue economy and blue growth initiatives. This overlooking leads to or accelerates processes of coastal and ocean grabbing, displacement, dispossession, and exclusion which strongly impact the livelihoods of marginalized coastal communities, particularly, small-scale fishers in various parts of the world. The collected evidence suggests that there is a missing link between international policy deliberations and national-level implementation plans in the blue economy context. Numerous studies claim that critical re-thinking of policies is required to ensure the sustainability of blue economy trajectories. Unchecked economic growth in the ocean as in other realms can reinforce inequities and unjust and inequitable resource distribution patterns. To pre-empt, mitigate, and resolve likely conflicts, deeper insights are needed to address the impacts of the blue economy and blue growth on coastal livelihoods. I suggest investigating the causes of conflict and further research on how governance responds to sustain small-scale fisheries while embracing the blue economy and blue growth agendas.
Los cuidados de larga duración en la Unión Europea
Authors: Martínez Martínez Verónica Lidia
Published: February 2023

Los cuidados de larga duración o cuidados a largo plazo en la Unión Europea es el objeto de estudio de este trabajo; por ello, con el auxilio de los métodos analítico y comparado, se parte de su conceptualización y de establecer las principales características de este tipo de prestaciones, para posteriormente abordar el tema referente a su falta de inclusión en el Reglamento 883/2004 y las propuestas de modificación de este ordenamiento, y del Reglamento 987/2009, para que sea posible que se reconozca a los cuidados de largo plazo como prestaciones de seguridad social.
La precarización de la vivienda y su relación con las finanzas públicas municipales en México (caso Culiacán, estado de Sinaloa)
Authors: Sosa Arellano Dasaev
Published: February 2023

Garantizar el acceso a la vivienda se ha convertido en uno de los mayores retos del Estado mexicano, ya que la protección y estímulo al acaparamiento inmobiliario ha provocado que las ciudades se desarrollen periféricamente, generando infraestructura de baja calidad, altos costos tanto para la población como para el gobierno, precarización de la vivienda y un crecimiento en el déficit presupuestal derivado de las claves catastrales de bajo costo.
Análise dos efeitos tóxicos relacionados aos resíduos farmacológicos na água tratada
Authors: Dick Victor , Rodrigues Gabriel , Thauan Victoria , Gonzalez Fabiana
Published: February 2023

Atualmente é notável a presença crescente de metabólitos medicamentosos e até mesmo de fármacos em sua forma inalterada na água tratada. Parte deste problema se dá com relação ao sistema de saneamento básico, que não acompanhou as exigências do avanço do setor farmacêutico e o crescente uso de drogas pela população. À longo prazo, podem ocorrer complicações, variando desde resistência de microorganismos até desregulação hormonal e afecção da fauna e flora em decorrência da dispersão destes resíduos no meio hídrico. Portanto é necessária uma revisão detalhada sobre possíveis efeitos tóxicos que podem trazer à sociedade, além de propostas, dispondo novas possibilidades para alterar tal situação.
Efeitos indesejáveis e respostas farmacológicas dos antidepressivos
Authors: Tibiriçá Leonardo , Veiga Marisa Regina de Fátima , Lopes Esther , Aparecida Maria , Weckx Juliana , Fukushima André Rinaldi
Published: February 2023

Os antidepressivos surgiram empiricamente através de observações em pacientes esquizofrênicos e com tuberculose. No caso dos pacientes esquizofrênicos, a imipramina surgira como sendo uma nova proposta da classe dos neurolépticos devido a semelhança estrutural à clorpormazina, entretanto não houve êxito algum, exceto a melhora no humor em pacientes deprimidos. Já no caso da tuberculose, a iproniazida era usada no tratamento da tuberculose e que também pôde ser observada elevação de humor em pacientes deprimidos. Em 1960, surge a primeira hipótese que tenta esclarecer a causa da depressão: a hipótese monoaminérgica, que dizia que a depressão era uma condição patológica onde o indivíduo apresentava depleção de serotonina, dopamina e noradrenalina e que os antidepressivos deveriam reestabelecer seus níveis em homeostase. Desde o surgimento da psicoterapia até os avanços atuais, ainda não é esclarecido totalmente as vias de neurotransmissores, receptores onde atuam ou mecanismo de ação de fármacos de ação central e isso pode estar relacionado com a sua estrutura, ao qual se denomina relação estrutura-atividade ou com seus receptores. Principalmente através do entendimento farmacodinâmico dos fármacos, é possível evitar interações medicamentosas ou justificar e evitar alguns efeitos colaterais. Com isso, o objetivo deste trabalho é apresentar através da análise das moléculas e padronizar com seus efeitos ou afinidades por determinados receptores, quando for possível estabelecer relação estrutura-atividade e justificar os efeitos colaterais através das interações com receptores para que se possa evitar interações ou potencializações de efeito, uma vez que este pode ser fatal.
POLÍTICA PÚBLICA NO COMBATE A DOENÇAS CRÔNICAS NÃO TRANSMISSÍVEIS: A PRESENCA DO EDUCADOR FÍSICO NA SAÚDE
Authors: Roah Rodrigues Rodrigo , Rafael de Brito  , Hirota Vinicius Barroso , Ricci Esther Lopes , Peña Muñoz Juliana Weckx , Fukushima André Rinaldi , Caperuto Erico Chagas
Published: February 2023

Introdução: O número de brasileiros com Doenças Crônicas Não Transmissíveis (DCNTs) tem subido exponencialmente. Dados do Ministério da Saúde apontam que a atividade física se caracteriza como procedimento não medicamentoso para prevenção e tratamento de diversas doenças, principalmente em relação às DCNTs, que são responsáveis por uma carga de 66% dos custos para a saúde pública. Objetivo: O objetivo da pesquisa é analisar as políticas públicas de saúde na implementação de programas destinados às práticas desportivas, sob supervisão de educadores físicos, oportunizados ao público idoso (60-69 anos), na cidade de São Bernardo do Campo. Método: Para tanto, fez-se uso da pesquisa descritiva. A coleta de dados utilizou da consulta dos dados públicos do município pela lei de acesso à informação entre os anos de 2015 a 2019. Resultados: Os resultados apontam um aumento de 8,78% no número total de óbitos por DCNTs no município, se compararmos o ano de 2015 com o de 2019. Dentre esses óbitos, as mortes por doenças cardiovasculares (1504 óbitos) é maior, em números absolutos, em relação aos óbitos por neoplasias (1361 óbitos); doenças respiratórias crônicas (273 óbitos); diabetes mellitus (125 óbitos) (2015-2019). Na média, as doenças cardiovasculares (300,8µ) são 10,5% maior do que a média de óbitos por neoplasias (272,2µ), segunda maior causa de óbitos (2015-2019). A cidade possui 35 bairros, com população idosa (60-69 anos) e 8 Unidades Básicas de Saúde (UBS’s) que possuem atividades físicos-desportivas, de responsabilidade dos educadores físicos do NASF. A distância mais longa entre o bairro e o polo NASF é de 5,3km. Conclusão: A Secretaria da Saúde de São Bernardo oportuniza vivências e atividades esportivas para idosos na faixa etária foco da pesquisa. Entretanto, dados preliminares indicam um número insuficiente de NASF para o atendimento de todos os bairros com população idosa, na faixa etária de 60 e 69 anos.
Prevalência e análise clínica-epidemiológica de casos de intoxicação nas unidades de terapia intensiva de um Hospital Universitário no Paraná.
Authors: Cerri Ana Cecília , Bortoli Stella
Published: February 2023

Intoxicação é o processo de desequilíbrio de um organismo devido à exposição a agentes tóxicos, geralmente exógenos, podendo ser aguda ou crônica e que tem diversas etiologias. Um exemplo de consequência aguda em decorrência de uma exposição crônica é a hemorragia digestiva alta (HDA) que pode se manifestar em casos de exposição crônica ao álcool. O presente trabalho investigou nos registros físicos das quatro Unidades de Terapia Intensiva (UTIs) do Hospital Universitário Regional dos Campos Gerais (HURCG) no período entre janeiro de 2019 a abril de 2022 os casos relacionados à intoxicação exógena, hematêmese, melena e HDA. Os prontuários selecionados cuja causa da intoxicação foi em consequência do abuso de substâncias foram estudados quanto as variáveis: sexo, idade, agente causador e desfecho. Foram encontrados 112 casos de HDA, sendo 94 (83,9%) causados por etilismo, 15 (13,4%) por uso de medicamentos apenas e três (2,7%) por etilismo e uso de medicamentos concomitantemente. A maioria dos casos de HDA ocorreu em homens em decorrência do etilismo, sendo a faixa etária mais atingida de 55-64 anos e do total de casos estudados, 49,1% tiveram alta e 43,8% foram a óbito. Já para intoxicação exógena foram encontrados 26 casos, a maioria ocorreu em mulheres em circunstância autoinfligida, a idade variou entre 15-86 anos, e do total de casos de intoxicação, 80,8% tiveram alta e 15,4% foram a óbito. Baseado nessas observações, é possível apontar a necessidade de melhorias na atenção à saúde mental da sociedade, em especial ao abuso de substâncias e suas consequências, reforçando a necessidade dos gestores do sistema de saúde e dos governantes implementarem e fortificarem políticas públicas de prevenção de suicídio e combate ao uso de álcool e outras drogas.
The Current Status of Arabic Language Teaching in Nigeria: Challenges and Developments
Authors: Gbodofu Khalil Mohammad Usman
Published: February 2023

We discuss in this paper the teaching of the Arabic Language in Nigeria in the 21st century, considering the challenges that face this language and the developments it gains from its lovers and scholars in this country. Therefore, we started by narrating the history of Nigeria and emergence of Arabic Language therein, as we mentioned the means through which it arose in the country. We discussed the role of the colonialists in the weakness of the standard of Arabic Language and the contribution of some Arabic scholars in translating many English texts into Arabic. We also investigated the conditions of Arabic education in Nigerian universities and into the benefits for some students of Arabic Language with modern technological education.
A Critical Review of Nanomaterials and Their Industrial Applications
Authors: Shankar Dr Vijayalakshmi , Ranjitha Dr
Published: February 2023

The innovative and universal nature of nanotechnology has extensively driven the interest of scientists for the past few decades. Besides its utilization in several sectors such as pharmaceuticals & drug development, with highly funded government projects to develop a wide range of nanotech-based products, its commercialism is still comparatively poor. Although these technologies enable to resolve the issues with drugs in the pharmaceutical industry, especially reformulating the drugs to improvise their physicochemical properties & the level of toxicity (including the rate of dissolution, bioaccumulation & its toxicological nature compared to the standards recorded in scientific reports. Depending on the experience gained from decades of nanotechnology-derived drug delivery systems and an extensive literature review, it was determined that the main reason for commercialization failure was listed as follows a) insufficient regulative framework system; b) poorly accepted & supported by the consumers (the public), doctors in practice & industries; c) manufacturing criteria including the capability for large-scale production, characterization, quality control, and suitable translation; 4) issues with toxicity, ecological hazardous & safety profiles; 5) inadequate interdisciplinary platforms; and, 6) Lack of IPR (Intellectual property rights) protection. This present review elaborates on the key issues & the trends followed in the industries, the Regulatory role of the USFDA with implications, and the challenges set forth for the successful translation of nanotech-based products from the laboratory to the market.
Incidência de tuberculose pulmonar ativa diagnosticada através do método de cultura a partir de amostras respiratórias de pacientes atendidos em um laboratório público do interior da Bahia.
Authors: Silva Vanessa dos Santos
Published: February 2023

A tuberculose (TB) é uma doença infecciosa grave. Tem como agente etiológico a bactéria da espécie Mycobacterium tuberculosis (MTB), também denominado bacilo de Koch. O presente estudo teve por objetivo avaliar a incidência da tuberculose pulmonar ativa diagnosticada através do método de cultura para micobactérias, com o intuito de verificar sua sensibilidade de detecção, fazendo uma análise comparativa com resultados do teste rápido molécula (TRMTB). Trata-se de um corte transversal, de base populacional, de abordagem quantitativa, com caráter descritivo e retrospectivo documental. Foram analisadas 1431 amostras de pacientes provenientes de 33 municípios, entre o período de fevereiro de 2018 a fevereiro de 2019. Foram obtidos resultados de cultura positivos para Micobactérias tuberculosas (MTB) em 107 amostras (35,0%) e para micobactérias não tuberculosas (MNTs) totalizando 6 amostras (2,0%). E 24 amostras (18,3%) apresentaram resultados negativos na cultura e positivas no teste molecular e 4 amostras (3,8%) apresentaram resistência à rifampicina no TSA. Portanto, o TRMTB, mostrou ter elevada sensibilidade quando comparado ao meio de cultura. Em contrapartida, a cultura, é capaz de detectar MNTs, diferente do TRMTB. E quando comparado os métodos para detecção de resistência a Rifampicina, o Teste de Sensibilidade aos Antimicrobianos (TSA) apresentou maior sensibilidade.
A pós-graduação brasileira à mercê de governos neoliberais
Authors: Alves Vilela Alba Benemérita
Published: February 2023

Vivenciamos nesses quatro anos os enfrentamentos que os cursos de pós-graduação lato senso e stricto sensu, e a pesquisa brasileira vem sofrendo, a despeito da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES e Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPQ, nas Fundações de Amparo à Pesquisa (FAPs), Universidades, Institutos de Pesquisa, Centros de Pesquisas, dentre outros protagonistas, tanto da pesquisa brasileira, quanto na formação de pesquisadores. Estamos nos referindo aos cortes e contingenciamentos de recursos do Governo Federal, através do Ministério da Educação, que não só retardaram, como, em alguns casos, impossibilitaram a execução de despesas previstas pelas Instituições referidas...
Mastite Granulomatosa Idiopática: desafios a serem superados
Authors: Martins Quartel Maria Luiza , Ferreira Flávia Aparecida , Cunha Costa Leonardo
Published: February 2023

O presente estudo teve como objetivo apresentar a mastite granulomatosa idiopática (MGI), uma doença da mama que possui achados de ampla variabilidade clínica. A MGI é uma doença inflamatória crônica da mama que acomete majoritariamente mulheres na faixa etária dos 30 aos 44 anos de idade em países em desenvolvimento. Não há nenhum fator causal identificado, mas sabe-se que costuma ocorrer nos 5 primeiros anos após a lactação. Trata-se de uma enfermidade que mimetiza sinais clínicos e radiológicos de condições como o câncer de mama. A doença se manifesta geralmente como uma massa unilateral mal definida, acometendo mais o quadrante superior externo da mama, apresentando consistência endurecida. O diagnóstico é feito pela constatação, ao exame histológico, de granulomas não caseosos e microabscessos confinados ao lóbulo mamário, após a exclusão de causas infecciosas e autoimunes. Até o momento, identificar os melhores meios diagnósticos, bem como as opções de tratamento para a MGI ainda é um desafio médico a ser superado. Os dados foram obtidos por meio de revisão de literatura nas bases de dados da Biblioteca Virtual de Saúde (bvs), Biblioteca Eletrônica Científica Online (SciELO, sigla em inglês) e PubMed. Foi possível constatar a dificuldade em estabelecer um esquema terapêutico padrão, visto que a conduta depende de critérios individuais. Diante de inúmeras possibilidades de manifestações clínicas, espera-se despertar o diagnóstico diferencial dessa doença com as patologias malignas da mama, de modo a evitar procedimentos desnecessários e fisicamente invasivos.
A contribuição da nutrição hospitalar no prognóstico da covid-19
Authors: Santos Lima Sibele
Published: February 2023

Resenha.
A eficácia do laser terapêutico em pacientes portadores de osteoartrite de joelho
Authors: Araújo de Medeiros Welleson , Quariguasi Ferreira Johnathan Allysson
Published: February 2023

A osteoartrite é uma doença osteocartilaginosa degenerativa com variados fatores de risco. Trata-se de um processo inflamatório crônico que provoca degeneração da cartilagem articular e outros tecidos a ela envolvidos. Com a evolução do desgaste da cartilagem, pode resultar no aparecimento de dor, edema, fraqueza muscular, instabilidade, perda de amplitude de movimento e redução da propriocepção. O objetivo do trabalho foi analisar qual a eficácia do laser terapêutico sendo utilizado como alternativa de tratamento em pacientes portadores de osteoartrite de joelho. O presente trabalho trata-se de uma revisão bibliográfica, foram realizadas pesquisas nas bases de dados científicas: SciELO, PubMed e PEDro. Os descritores foram utilizados conforme os Descritores em Ciências da Saúde - DeCS/MeSH. Dentre os artigos encontrados, foram inclusos artigos dos anos 2016 a 2021 nos idiomas inglês e português que abordassem o tema proposto. Pôde-se observar que a aplicação do laser terapêutico de baixa intensidade tem eficácia em pacientes portadores de osteoartrite de joelho, podendo ser constatada uma melhora importante da dor e funcionalidade. Pode-se concluir que o laser terapêutico apresenta-se como um recurso efetivo e fidedigno no tratamento de osteortrite de joelho, pois proporciona alterações fisiológicas que minimizam as respostas inflamatórias, amenizando o dano articular, o quadro álgico, e como consequência, uma melhora da funcionalidade e qualidade de vida.
A DE AÚ B DE BERIMBAU C DE CAPOEIRA: TRAJETÓRIA ESCOLAR DE UMA MULHER NEGRA
Authors: Ferreira Nunes Míghian Danae , Da Silva Ariana Lais
Published: February 2023

O presente artigo versa sobre a trajetória escolar de uma professora de capoeira, moradora de um município localizado no Recôncavo Baiano. Em março de 2020, ouvimos a trajetória escolar de Fortaleza, uma mulher negra.  Este texto está dividido em três seções: na primeira, tratamos dos percursos metodológicos, que contou com a utilização de abordagem qualitativa e entrevista semiestruturada; na segunda, tratamos dos referenciais teóricos apresentando os conceitos fundamentais para a análise; na terceira, temos duas subseções em que analisamos a trajetória de vida da entrevistada lançando mão dos aportes teóricos. Ao longo do texto surgiram aspectos que relacionam sua trajetória escolar com as fases de sua trajetória na capoeira, fazendo-nos perceber que sua vivência em ambiente escolar foi diferenciada, simultaneamente, por sua inserção e empenho na prática desde a década de 1990, bem como, pelos impactos da Constituição do Estado da Bahia de 1989, na história da educação da população negra baiana.
Pandemia
Authors: Paes Sarmento Albertina
Published: February 2023

Este e-book é o resultado do trabalho coletivo de professores e alunos vinculados ao Programa Residência Pedagógica, instituído pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), no período de 2020 a 2022. O Programa, de acordo com o Edital CAPES nº 01/2020, tem como objetivos: incentivar a formação de docentes em nível superior para a educação básica, conduzindo o licenciando a exercitar de forma ativa a relação entre teoria e prática profissional docente; promover a adequação dos currículos e propostas pedagógicas dos cursos de licenciatura às orientações da Base Nacional Comum Curricular (BNCC); fortalecer e ampliar a relação entre as Instituições de Ensino Superior (IES) e as SEI/CAPES, escolas públicas de educação básica para a formação inicial de professores da educação básica; e fortalecer o papel das redes de ensino na formação de futuros professores.
Evaluating 3D printed bioseparation structures using multi-length scale tomography
Authors: Johnson Thomas , Conti Mariachiara , Iacoviello Francesco , Shearing Paul , Pullen James , Dimartino Simone , Bracewell Daniel
Published: February 2023

X-ray computed tomography was applied in imaging 3D printed gyroids used
for bioseparation in order to visualize and characterize structures from
the entire geometry down to individual nanopores. Methacrylate prints
were fabricated with feature sizes of 500 µm, 300 µm and 200 µm, with
the material phase exhibiting a porous substructure in all cases. Two
X-ray scanners achieved pixel sizes from 5 µm to 16 nm to produce
digital representations of samples across multiple length scales as the
basis for geometric analysis and flow simulation. At the gyroid scale,
imaged samples were visually compared to the original computed aided
designs to analyze printing fidelity across all feature sizes. An
individual 500 µm feature, part of the overall gyroid structure, was
compared and overlaid between the design and imaged volumes where
individual printed layers could be identified. Internal subvolumes of
all feature sizes were segmented into material and void phases for
permeable flow analysis. Small pieces of 3D printed material were
optimized for nanotomographic imaging at a pixel size of 63 nm, with all
three gyroid samples exhibiting similar geometric characteristics when
measured. An average porosity of 45% was obtained that was within the
expected design range and a tortuosity factor of 2.52 was measured.
Applying a voidage network map enabled the size, location and
connectivity of individual pores to be identified, obtaining an average
internal pore size of 793 nm. Using the Avizo XLAB plugin at a bulk
diffusivity of 7.00 x10 m s
resulted in a simulated material diffusivity of
2.17 x10 m s
± 0.16 x10 m
s .
Analysis of genotype by environmental interaction of common wheat (Triticum Aestivum L.) by non-parametric stability methods
Authors:   Department of Wheat Breeding and Technology, Agronom Breeding Company, Dobrich, Bulgaria, Tsenov Nikolay , Gubatov Todor ,   Department of Wheat Breeding and Technology, Agronom Breeding Company, Dobrich, Bulgaria, Yanchev Ivan ,   Agricultural University – Plovdiv, Bulgaria
Published: February 2023

Data from the Multi Environmental Field Trail (MET), which examined 24 varieties of common wheat, were divided into three "datasets" related to three of the five study locations. Using meta-analysis, these three data sets were compared with those from the whole experiment. The aim of the study is to determine whether a 4-year growing period in three country-specific locations, it is possible to establish a significant impact of the environment on the stability of a group of varieties. The analysis of the genotype x environment interaction (GEI) was performed in parallel in the three groups of data, which were compared with the entire MET database. A direct comparison was made on them regarding the possibilities of non-parametric methods to assess the stability of the variety. The analysis of the results of the four "datasets" is done through a number of statistical approaches, allowing them to be correctly compared at different levels. Genotype x environment interaction was found in each of the studied locations. The variation in yield in them is a result of the direct effect of the "year" and the combined effect of the genotype x year. At all three locations, the GEI is broken down into four main components, which is evidence of the strong linear and non-linear nature of the dispersion of grain yield. These results are a prerequisite for an objective assessment of genotype stability. All applied parameters give completely similar stability information for each of them, regardless of the test location. Data from one location are sufficient to assess the stability of each variety in a group. This may be the case if significant differences between the seasons of the trial, are found. The applied non-parametric methods for stability assessment give correct information about the varieties, in the presence of GEI, regardless of the conditions from which the data for analysis are selected.
Effect of additionally BCAA supply on imazamox-treated sunflower and antioxidative defense system
Authors:   Agricultural University-Plovdiv, Bulgaria, Balabanova Dobrinka
Published: February 2023

Sunflower is an economically important oilseed crop worldwide and weeds have a negative effect on its yields. The herbicide imazamox, combined with imazamox-resistant (IMI-R) sunflower hybrids, is a technology known as the Clearfield production system and successfully controls weeds. The mechanism of action of the herbicide imazamox is related to blocking the AHAS enzyme, which catalyzes the first step in the biosynthetic pathway of the branched-chain amino acids (BCAA). In the present study, we investigated the effect of the supplementary addition of BCAA to imazamox-treated IMI-R sunflower plants and antioxidative metabolism. Our results showed that the additional application of BCAA has a beneficial effect on both the total protein content and the activity of the antioxidant defense system of plants. This amelioration is probably a secondary effect of the enhanced protein metabolism and the supposed direct involvement of the three amino acids in the overall protein turnover.