bluuebunny/crossref_metadata_2025 huggingface dataset:
A RARE CASE OF GIANT CELL TUMOUR (OSTEOCLASTOMA) OF THE TALUS: A CASE REPORT
Authors: Bahar Mazarbhuiya Imran , Chandra Paul Gautam , Das Trinayan , Das Purkayastha Souvik
Published: May 2024

Aim and Objective:This study aims to describe a rare case of giant cell tumor (GCT) of the talus. Background:Giant cell tumors rarely present around bones of the foot and involvement of the talus is infrequent. In comparison to long bones,diagnosis and management of talus GCT is challenging and is sparsely reported in the literature. Case Description: We report a case of GCT arising from the talus in a 23-year-old male, presenting as non-specific ankle pain and instability for the past 2 years.The diagnosis was established by CT and MRI and was treated with excisional curettage and antibiotic impregnated bone cement application. At 6 months of follow-up, the symptoms of the patient had resolved clinically and no sign of recurrence at last clinico-radiological examination. Conclusion: Diagnosis and management of GCT talus is challenging and can be treated with excisional curettage and antibiotic impregnated bone cement application. Clinical Significance: Presentation of GCT talus may be missed at early stages. A high index of suspicion can help in diagnosis and appropriate management.
CHALLENGES IN ENGLISH LANGUAGE EDUCATION FOR TRIBALS WITH SPECIFIC REFERENCE TO CHHATTISGARH STATE
Authors:   Research Scholar (English), (Kalinga University, Raipur)., T.M Jessy , Vijayanand A. ,   Professor, (Kalinga University, Raipur) Department of English.
Published: May 2024

The state of Chhattisgarh, which was formed in 2000, is home to a significant tribal population, particularly in regions like Bastar. Despite being rich in tribal culture and heritage, these communities face numerous challenges in English language education. This paper highlights the obstacles that hinder English language acquisition among tribal students in Chhattisgarh. These challenges include social circumstances, political indifference, poor school infrastructure, illiteracy, poverty, and the impact of Naxal violence. Understanding the importance of English as a global language, the paper aims to analyze these issues and shed light on the difficulties faced by tribal students in acquiring English language skills in the state.
Terminological support for the systematicity of tax regulation as a basis for achieving a balance of interests of participants in tax relations in Ukraine
Authors: Savvi Oleksandr
Published: May 2024

The relevance of the research topic is backed by the fact that the current tax legislation and other industrylegislation bordering on tax regulation cannot be defined as a systemic, coordinated framework. There arefundamental differences both between certain legislative acts and between certain legislative norms withinone act. The relevance is further forced by the fact that the respective influence on achieving systematic taxlegislation is yet to be taken into account considering the provisions of the Law of Ukraine "On Policy-Making Activities". The purpose of the article is to analyze the terminological aspects that express thecontent of tax regulation, which is carried out in view of the systemic criteria for composition of tax law. Theresearch applies methods of scientific knowledge that specify the problematic nature of the consideration ofissues, namely the systematic method (through which the systematicity of tax law and the systematicity of taxlegislation is investigated), comparative (through which a comparative analysis of the development dynamicsand changes in legislative norms is carried out), prognostic (through which the conclusions regarding theprospects for changing the tax legislation system are made). The comparative nature of the system of both taxlaw and tax legislation is researched. The tax glossary is characterized through the possibilities andconsequences of formulating a stable construction of definitions that expressly ensure tax regulation. Theanalysis of the raised issues is carried out through determining a number of aspects based on the assessmentof the norms of the Law of Ukraine "On Policy-Making Activities". The classification of laws in the context oftax regulation is provided. The system of legislative impact is based on the consistency of the relevant rulesfrom a constitutional norm to a norm of a bylaw . Emphasis is placed on two original constitutionalconstructs (Articles 67, 92 of the Constitution of Ukraine), which are further specified in the relevant taxlegislation. On the basis of the conducted research, conclusions and recommendations were developed that aclear consideration of a particular balance of norms contributes to the elimination of gaps and conflicts intax regulation. Achieving a balance of interests of the participants in tax relations cannot occur in case ofsystematic ignoring and violation of policy-making procedures. Article 4 of the Tax Code of Ukraineestablishes unanimous requirements regarding the stability of tax legislation, the objective necessity of acertain period of delay between the moment of adoption of a legislative norm and its entry into force.
AI for clean water: efficient water quality prediction leveraging machine learning
Authors: Ansari Ahmad Talha , Nigar Natasha , Faisal Hafiz Muhammad , Shahzad Muhammad Kashif
Published: May 2024

Water is one of the most critical resources for maintaining life. Although it makes upto 70% of the Earth’s surface but only a small amount of it is usable. Since water is used for a variety of functions, its quality must be determined before usage. The rapid increase of the world’s population has also had a significant influence on the environment, particularly on water quality. The quality of water has been deteriorating in recent years due to various pollutants. To control the water pollution, modeling and predicting the water quality has become a crucial need. In this work, we propose a machine learning (ML)-based model to predict and classify the water quality. The results from six different ML models are analyzed for accuracy, precision, recall, and F1 score as performance measures. The proposed approach is validated using benchmark dataset. The results show that Decision Tree ML model has a distinct superiority on other classifiers in terms of performance indicators like accuracy of 97.53%, precision of 87.66%, recall of 74.59%, and F1-score of 80.60%. This will help the aquatic system for better water quality analysis.
Comprehensive Analysis of Omicron Subvariants: EG.5 Rise, Vaccination
Strategies, and Global Impact
Authors: Sil Debayan , Gautam Shreastha , Saxena Shubhi , Joshi Sachin , Kumar Dinesh , Mehta Astha , Jindal Priya , Sharma Subhi , Pandey Prachi , Diksha  , Singh Amandeep
Published: May 2024

:

The emergence of new variants of the SARS-CoV-2 virus during the COVID-19 pandemic
has prompted significant developments in the understanding, monitoring, and response to
these strains. This comprehensive review focuses on two prominent variants of interest (VoI), XBB.
1.5 (Kraken) and XBB.1.16 (“Arcturus”), along with seven variants under observation (VuM),
including EG.5. The World Health Organization (WHO) identified these variants in July 2023,
highlighting EG.5's noteworthy rise in prevalence. EG.5, also known as “Eris,” has exhibited an increased
effective reproductive rate, prompting concerns about its contagiousness and immune evasion
capabilities. With an altered spike protein in the Receptor-Binding Domain (RBD), EG.5
shares similarities with XBB.1.5 but surpasses it in prevalence, constituting 20% of COVID-19
cases in the United States by late August. EG.5's subvariant, EG.5.1, poses challenges with mutations
like Q52H and F456L, contributing to its ability to bypass neutralizing antibodies. The global
distribution of SARS-CoV-2 variants presents a dynamic landscape, with XBB.1.16 and other
strains gaining prominence. The advent of the BA.2.86 variant further complicates the scenario,
with its notable spread in regions lacking robust viral surveillance. A thorough analysis of mutations
reveals the evolving nature of the Omicron variant, with distinct amino acid changes characterizing
XBB.1.5, XBB.1.16, and EG.5. The WHO designates EG.5 as a “variant of interest” due
to its increased contagiousness and potential immune evasion, emphasizing the need for vigilant
monitoring. The risk assessment of EG.5 underscores its rapid development and growing prevalence
globally. While booster vaccines targeting XBB.1.5 are in development, antiviral medications
like nirmatrelvir/ritonavir (Paxlovid) continue to exhibit efficacy. In the context of the evolving
variants, the FDA has granted emergency use authorization for updated COVID-19 vaccines
targeting circulating strains, reflecting the adaptability of vaccination strategies to address emerging
challenges. This comprehensive overview provides a nuanced understanding of the diverse
Omicron subvariants, their global impact, and the ongoing efforts to combat their spread through
vaccination and therapeutic interventions.
Prevention of Anaemia in Pregnancy: A Five-year Scoping Review
Authors: Abiodun-Ojo Olubukola E. , Ogundipe Laofe O. , Bello Cecilia B.
Published: May 2024

:

Approximately 50% of pregnant women globally suffer from pregnancy-related
anaemia, which is a serious issue for reproductive health and can lead to a number of complications, including low birth weights, premature deliveries, foetal deformities, and feto-maternal
mortality.

Aim:

This study aimed to evaluate the suggested strategies to prevent anaemia in pregnancy
through a 5-year scoping review (November, 2017 to November, 2022).

Methods:

A comprehensive list of keyword combinations linked to anemia prevention in pregnancy and pertinent approaches to inform the search strategy were evaluated. Significant
events, including pregnancy and anemia, were cross-referenced with the frequency and variability of terms across time. Literature from Pubmed (MEDLINE), Google Scholar, PLOS One,
and Cochrane database were reviewed.

Results:

Evidence-based preventative therapy options for iron deficiency anaemia in pregnancy
include prophylactic iron supplementation, food fortification with iron and folate, and health
education. There is a wealth of research on the effects of these therapies on the occurrence of
anaemia during pregnancy. However, these prospects are endangered by several variables, such
as inadequate health facilities, low maternal health literacy, low utilisation of maternal health
care in developing countries, a dearth of resources for health education, and lack of a government policy that prevents anaemia during pregnancy.

Conclusion:

If the highlighted challenges are appropriately addressed through the provision of
health education material, the effectiveness of anaemia prevention in pregnancy could be sustained.
Synthesis and Antibacterial Evaluation of Novel Small-Molecule Antibacterials of a Reduced Acridine Structure in S. aureus Strains Including MRSA
Authors: Werner Peter , Kreutzer David , Szemeredi Nikoletta , Spengler Gabriella , Hilgeroth Andreas
Published: May 2024

Background:

The increasing antibacterial drug resistance remains a threat to global
health with increasing mortality and morbidity. There is an urgent need to find novel antibacterials
and develop alternative strategies to combat the increasing antibacterial drug resistance.

Objective:

We aimed to synthesize novel small-molecule antibacterials to evaluate the structuredependent
antibacterial compound activities against S. aureus and MRSA.

Methods:

Compounds were synthesized by primary N-alkylation to form alkyl acridinium salts that
were further functionalized with substituted phenyl residues and finally purified by column chromatography.
The antibacterial growth inhibition activity was determined as MIC value.

Results:

The substituent effects on the determined antibacterial growth inhibitory properties have
been discussed.

Conclusion:

The best activities have been found for compounds with methoxy functions, exceeding
the activities of reported novel antibacterial peptides. The compounds have also shown antibacterial
drug-enhancing effects, which have been manifested as a reduction in the MIC values of the used
antibiotics.
Development of a Prognostic Risk Model Based on Oxidative Stress-related Genes for Platinum-resistant Ovarian Cancer Patients
Authors: Su Huishan , Hou Yaxin , Zhu Difan , Pang Rongqing , Tian Shiyun , Ding Ran , Chen Ying , Zhang Sihe
Published: May 2024

Introduction:

Ovarian Cancer (OC) is a heterogeneous malignancy with poor outcomes.
Oxidative stress plays a crucial role in developing drug resistance. However, the relationships
between Oxidative Stress-related Genes (OSRGs) and the prognosis of platinum-resistant
OC remain unclear. This study aimed to develop an OSRGs-based prognostic risk model for platinum-
resistant OC patients.

Methods:

Gene Set Enrichment Analysis (GSEA) was performed to determine the expression difference
of OSRGs between platinum-resistant and -sensitive OC patients. Cox regression analyses
were used to identify the prognostic OSRGs and establish a risk score model. The model was validated
by using an external dataset. Machine learning was used to determine the prognostic OSRGs
associated with platinum resistance. Finally, the biological functions of selected OSRG were determined
via in vitro cellular experiments.

Results:

Three gene sets associated with oxidative stress-related pathways were enriched (p <
0.05), and 105 OSRGs were found to be differentially expressed between platinum-resistant and -
sensitive OC (p < 0.05). Twenty prognosis-associated OSRGs were identified (HR: 0:562-5.437;
95% CI: 0.319-20.148; p < 0.005), and seven independent OSRGs were used to construct a prognostic
risk score model, which accurately predicted the survival of OC patients (1-, 3-, and 5-year
AUC=0.69, 0.75, and 0.67, respectively). The prognostic potential of this model was confirmed in
the validation cohort. Machine learning showed five prognostic OSRGs (SPHK1, PXDNL,
C1QA, WRN, and SETX) to be strongly correlated with platinum resistance in OC patients. Cellular
experiments showed that WRN significantly promoted the malignancy and platinum resistance
of OC cells.

Conclusion:

The OSRGs-based risk score model can efficiently predict the prognosis and platinum
resistance of OC patients. This model may improve the risk stratification of OC patients in
the clinic.
Analysis of Soil Health Parameters to Identify Important Soil Nutrients and Weights using Feature Engineering for Multiple Agri-Advices
Authors: Vispute Sushma , Goyal Dinesh , Sankhla Kriti
Published: May 2024

Introduction:

Identification of important soil nutrients is a very important task for precision
farming and developing efficient machine learning models.

Method:

The existing work shows that the patent is filed and published on a method and device for
assessment of soil health parameters and recommendation of fertilizers. The existing work is done
for one advice at a time not for several advices. Multiple advices that are taken into account for the
task are appropriate crops, organic fertilizer, and combination 1 and combination 2 of fertilizers.

Result:

This paper presented results of feature selection techniques based on Chi-Square, ANOVA
and Mutual Information Gain scoring functions such as Select K Best and Select Percentile for multiple
agri-advice datasets of Pune District regions to identify important soil health features.

Conclusion:

As per Chi-Square, ANOVA and Mutual Information scoring functions with Select K
Best and Select Percentile techniques ‘Mn’ was the most important parameter and Cu’ and ‘B’ were
the least important parameters among all 11 parameters common in 4 agriculture advices. Whereas
Ph, K, Fe, 'OC', 'N', 'S', 'Mn', and 'P' will be used for future research work on the development of an
efficient classification algorithm for multi-advice generators.
Recent Developments of Nanostructured Photocatalysts Based on
Semiconducting Chalcogenides for Organic Reactions
Authors: Hazarika Ramani , Roy Deepshikha , Das Deepshikha , Deori Kalyanjyoti
Published: May 2024

:

The earth-abundant metal chalcogenide is a highly versatile semiconductor with unique electronic and optical properties that seem to outperform
the photocatalytic properties of metal oxides and metal nanoparticles. For ages, researchers are reaping the benefits of its photocatalytic properties
in numerous reactions. However, the high charge recombination rates, poor compositional stability, and a smaller number of catalytically active
sites restrict its application. The development of different kinds of heterojunctions by the combination of metal-chalcogenides with other
conducting and semiconducting materials like metal oxides, metal nanoparticles, g-C3N4, single-atom catalysts, and MOF results in superior
photocatalytic activity. This review provides insight into the various classes of metal-chalcogenide-based heterostructures and their application in
various organic transformations. A brief overview of the synergistic properties arising from the development of such heterostructures helps to
understand the surface interactions so that highly stable, efficient, and selective metal-chalcogenide-based heterostructures can be developed for
industrially important photocatalytic organic transformations. This review also describes the role of mediators in boosting the stability and catalytic
efficiency of the metal chalcogenides. Moreover, a thorough emphasis on the morphological impact of photocatalysts in various reactions will help
with the development of metal chalcogenide heterostructures with tunable morphology and bandgap.
Prevalence and Disparities in Telehealth Use Among US Adults Following the COVID-19 Pandemic: National Cross-Sectional Survey (Preprint)
Authors: Spaulding Erin M , Fang Michael , Commodore-Mensah Yvonne , Himmelfarb Cheryl R , Martin Seth S , Coresh Josef
Published: May 2024

BACKGROUND

Telemedicine expanded during the COVID-19 pandemic, though use differed by age, sex, race or ethnicity, educational attainment, income, and location. It is unclear if high telehealth use or inequities persisted late into the pandemic.

OBJECTIVE

This study aims to evaluate the prevalence of, inequities in, and primary reasons for telehealth visits a year after telemedicine expansion.

METHODS

We used cross-sectional data from the 2022 Health Information National Trends Survey (HINTS 6), the first cycle with data on telemedicine. In total, 4830 English- and Spanish-speaking US adults (aged ≥18 years) were included in this study. The primary outcomes were telehealth visit attendance in the 12 months before March 7, 2022, to November 8, 2022, and the primary reason for the most recent telehealth visit. We evaluated sociodemographic and clinical predictors of telehealth visit attendance and the primary reason for the most recent telehealth visit through Poisson regression. Analyses were weighted according to HINTS 6 standards.

RESULTS

We included 4830 participants (mean age 48.3, SD 17.5 years; 50.28% women; 65.21% White). Among US adults, 38.78% reported having a telehealth visit in the previous year. Telehealth visit attendance rates were similar across age, race or ethnicity, income, and urban versus rural location. However, individuals with a telehealth visit were less likely to live in the Midwest (adjusted prevalence ratio [aPR] 0.65, 95% CI 0.54-0.77), and more likely to be women (aPR 1.21, 95% CI 1.06-1.38), college graduates or postgraduates (aPR 1.24, 95% CI 1.05-1.46), covered by health insurance (aPR 1.56, 95% CI 1.08-2.26), and married or cohabitating (aPR 1.17, 95% CI 1.03-1.32), adjusting for sociodemographic characteristics, frequency of health care visits, and comorbidities. Among participants with a telehealth visit in the past year, the primary reasons for their most recent visit were minor or acute illness (32.15%), chronic disease management (21%), mental health or substance abuse (16.94%), and an annual exam (16.22%). Older adults were more likely to report that the primary reason for their most recent telehealth visit was for chronic disease management (aPR 2.08, 95% CI 1.33-3.23), but less likely to report that it was for a mental health or substance abuse issue (aPR 0.19, 95% CI 0.10-0.35), adjusting for sociodemographic characteristics and frequency of health care visits.

CONCLUSIONS

Among US adults, telehealth visit attendance was high more than a year after telemedicine expansion and did not differ by age, race or ethnicity, income, or urban versus rural location. Telehealth could continue to be leveraged following COVID-19 to improve access to care and health equity.
Empowering patients with heart failure and their caregivers: Development and usability of the “My Voice” advance care planning website (Preprint)
Authors: Malhotra Chetna , Yee Alethea , Ramakrishnan Chandrika , Kaurani Sanam Naraindas , Chua Ivy , Lakin Joshua R , Sim David , Balakrishnan Iswaree , Liang Vera Goh Jin , Weiliang Huang , Fong Ling Lee , Pollak Kathryn I
Published: May 2024

BACKGROUND

Web-based advance care (ACP) interventions offer a promising solution to improve ACP engagement. However, there is lack of web-based ACP decision aids tailored for patients with heart failure, incorporating mechanisms to revisit patients’ care goals, and rarely involve caregivers.

OBJECTIVE

To develop and assess the usability and acceptability of a web-based advance care planning (ACP) decision aid named “My Voice”, tailored for patients with heart failure and their caregivers.

METHODS

The study team and advisory board co-developed the content for both patient and caregiver modules in “My Voice”. Employing a mixed methods approach, we iteratively tested usability and acceptability, incorporating feedback from patients, caregivers, and healthcare providers.

RESULTS

We interviewed 30 participants (11 patients, 9 caregivers, and 10 healthcare providers). Participants found the website easy to navigate, with simple and clear content facilitating communication of patients’ values and goals. They also appreciated that it allowed them to revisit their care goals periodically. Feedback prompted revisions to enhance user-friendliness for older patients, reduce wordiness, and increase empathy. The website met usability thresholds for all participant groups. Patients and caregivers’ ratings met acceptability thresholds for all items; healthcare providers’ ratings met acceptability thresholds for 11 of the 15 items.

CONCLUSIONS

“My Voice” shows promise as a tool for patients with heart failure to initiate and revisit ACP conversations with providers and caregivers. We will evaluate its efficacy in improving patient and caregiver outcomes in a randomized controlled trial.

CLINICALTRIAL

Not applicable
A qualitative approach to caregiver experience testing of an online adaptation of REACH II: GamePlan4Care (Preprint)
Authors: Cho Jinmyoung , Birchfield Thomas , Ory Marcia G , Stevens Alan B
Published: May 2024

BACKGROUND

GamePlan4Care (GP4C) is an online adaptation of the Resources for Enhancing Alzheimer’s Caregiver Health II (REACH II) intervention, redesigned and reformatted for online delivery.

OBJECTIVE

The goal of GP4C is to create an online family caregiver support platform that facilitates self-directed exposure to evidence-based skills-training and support for caregivers of persons living with dementia (PLWD). This multi-dimensional approach of utilizing technology enhanced with live support has the potential for improved scalability and sustainability.

METHODS

In preparation for a randomized clinical trial of the new intervention, the GP4C platform underwent user interface/user experience (UI/UX) testing with caregivers as part of an iterative design process. Testing of caregivers’ reactions to technical and content-related aspects of the platform was conducted with 31 caregivers recruited through partner organizations in central Texas.

RESULTS

The thematic analysis revealed three themes: supportive resources as a common theme, a comprehensive approach for technical aspects of the platform, and active engagement for content aspects of the platform. Participants also suggested changes in navigation and content.

CONCLUSIONS

Findings from the usability testing sessions indicate that the features of the platform would be beneficial to meet the needs and provide resources for caregivers of PLWD.

CLINICALTRIAL
Interest in the Use of Herbal Supplements to Close the Treatment Gap for Hazardous Alcohol Use Among Men Who Have Sex With Men: Secondary Analysis of a Cross-Sectional Study (Preprint)
Authors: Hernandez Christopher , Rowe Christopher , Ikeda Janet , Arenander Justine , Santos Glenn-Milo
Published: May 2024

BACKGROUND

Hazardous alcohol consumption is highly prevalent for men who have sex with men (MSM). The 4 treatments currently approved by the Food and Drug Administration for alcohol use are reaching an alarmingly low percentage of people who would benefit from a reduction in their alcohol use. There is increasing interest in alternative methods of treatment, such as herbal supplements, to address hazardous drinking. However, research on the acceptability of alternative pharmacotherapies among MSM remains limited.

OBJECTIVE

We examined the prevalence and correlates of expressing interest in using herbal supplements for alcohol treatment among MSM with hazardous alcohol consumption.

METHODS

We conducted a secondary data analysis from a cross-sectional study of MSM who use alcohol, conducted from March 2015 to July 2017 in San Francisco, California, to assess the overall prevalence of interest in using herbal supplements to help reduce alcohol consumption. Associations between expressing interest in herbal supplements and demographic, social, and clinical characteristics were examined using bivariate and multivariable logistic regression models.

RESULTS

One-third (66/200, 33%) of the participants expressed interest in an herbal supplement for reducing alcohol consumption. In the multivariable analyses, weekly binge drinking (adjusted odds ratio [aOR] 2.85, 95% CI 1.17-6.93), interest in abstaining from alcohol use (aOR 5.04, 95% CI 1.46-17.40), higher severity of alcohol dependence score (aOR 1.22, 95% CI 1.04-1.41), and interest in naltrexone (aOR 3.22, 95% CI 2.12-4.91) were independently associated with higher odds of being interested in using an herbal supplement to reduce alcohol consumption, adjusting for age, race or ethnicity, and education.

CONCLUSIONS

We found that MSM who have hazardous drinking habits, more severe alcohol dependence, and interest in pharmacotherapy were more likely to express interest in using an herbal supplement for reducing alcohol consumption. To our knowledge, this is the first study that has evaluated correlates of interest in herbal supplements for alcohol use among MSM. As researchers implement novel alcohol treatment studies, they should focus on recruitment efforts among MSM with a motivation to reduce their alcohol use patterns.
The Impact of Long-chain Omega-3 polyunsaturated fatty acids (LCPUFA) Supplementation in Pregnant Women Towards the Intelligence Status of Early Childhood: Protocol for Systematic Review and Meta-Analysis (Preprint)
Authors: Lim Han Yin , Mohammad Fadzil Mohammad Adi , Mustar Suraiami , Abdul Shukor Imanul Hassan , Mohamed Wan Ahmad Syazani
Published: May 2024

BACKGROUND

Long-chain omega-3 polyunsaturated fatty acids (LCPUFA) is an essential fatty acid that serves to protect cellular structures and provide energy, particularly for the fetal growth and development. As maternal supplementations of omega-3 LCPUFA may affect the rate of intelligence in early childhood development.

OBJECTIVE

The current systematic review is intended to synthesize available evidence on the impact of omega-3 LCPUFA supplementation during pregnancy towards intelligence in early childhood development.

METHODS

We will only include randomized controlled trials on pregnant women supplemented with omega-3 LCPUFA interventions and the outcome measured is the children’s intelligence. Based on the World Health Organization's definition of early childhood, we will include children who are eight years old or younger. Children's intelligence can be indicated using several tools measuring their intelligence index, such as cognition, attention, motor, language, behaviour, vision or neurodevelopment. Irrelevant and unavailable articles will be excluded. A systematic search will be conducted in three electronic databases, namely PubMed, Scopus and Cochrane using relevant and synonymous terms. Study screening and selection will be conducted by the authors based on eligibility criteria. Upon encountering conflicting decisions, a discussion will be held to reach a consensus. The screening and selection process will be recorded using a PRISMA flowchart. The included studies will be subjected to bias and quality assessment in accordance with the Critical Appraisal Skills Programme (CASP) Risk of Bias assessment inventory for randomized controlled trials.

RESULTS

An initial search was conducted on November 1st, 2023, which returned 1998 articles for screening. The extracted data will be classified into groups and subgroups according to the indicator of intelligence measured in the study. Next, the extracted data will be summarised using tables of evidence. Whenever possible, meta-analysis of homogeneous groups of articles will be conducted using statistical software such as SPSS and STATA. Studies with significant heterogeneity will be discussed narratively. The systematic review is estimated to be published at the year end of 2024.

CONCLUSIONS

This study will systematically pool the evidence on the potential use of omega-3 LCPUFA supplementation to improve children’s intelligence status. This review is also important in addressing any existing knowledge gaps on this topic. Finally, a deeper understanding on the association between consumption of omega-3 LCPUFA supplementation during pregnancy and children’s intelligence will aid policymakers, healthcare practitioners and mothers with more informed evidence-based decisions.

CLINICALTRIAL

PROSPERO CRD42023463910
MOLECULAR DOCKING DYNAMICS OF SELECTED BENZYLIDENE AMINO PHENYL ACETAMIDES AS TMK INHIBITORS USING HIGH THROUGHPUT VIRTUAL SCREENING (HTVS)
Authors: JAYANTHI KOPPULA , AHMED SYED SUHAIB , BAQI MOHD ABDUL , AFZAL AZAM MOHAMMED
Published: May 2024

Objective: Thymidylate kinase (TMK) plays a crucial role in bacterial DNA synthesis by catalyzing the phosphorylation of deoxythymidine monophosphate (dTMP) to form deoxythymidine diphosphate (dTDP). Consequently, this enzyme emerges as a promising target for developing novel antibacterial drugs. However, no antibiotics were reported for this target, especially active against Staphylococcus aureus thymidylate kinase.
Methods: Benzylidene acetamide-based ligands were examined for their potency using the in silico method. These novel ligand structures were built using ChemDraw software. The protein was retrieved from the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) website. The molecular docking and binding free energy calculation by prime Molecular Mechanics in Generalized Bond Surface Area (MM-GBSA) was performed for selected ligands. A 100 ns molecular dynamic simulation was also performed to assess the stability of the potential ligand as TMK inhibitors.
Results: All ten molecules have shown good glide scores and hydrophobic and hydrogen hydrophobic hydrogen bonding interactions with Arg48, Arg36, and π-π stacking Phe66 in the TMK enzyme (PDB: 4HLC). Among them, N-(2-ethylphenyl)-2-(4-((4-nitrobenzylidene) amino) phenoxy) acetamide molecule had high XP-docking scores of-3.27 kcal/mol based on extra-precision data. Prime Molecular Mechanics in Generalized Bond Surface Area study (MM-GBSA) studies also showed promising binding affinities that are ΔBind (-65.80), ΔLipo (-28.55), and ΔVdW (-55.10). Phe66 amino acid residue maintained continuous connections with the ligand during MD simulation. This ligand showed promising binding affinity with the SaTMK target.
Conclusion: The N-(2-ethylphenyl)-2-(4-((4-nitrobenzylidene) amino) phenoxy) acetamide ligand at the position of the benzene ring displayed nitrogen and oxygen group, thus indicating good potential activity as the inhibitor of TMK to treat antibacterial agents.
DEVELOPMENT AND VALIDATION OF A SIMPLE AND COST-EFFECTIVE UV SPECTROPHOTOMETRIC METHOD FOR QUANTIFYING LINEZOLID
Authors: CHAUHAN ITI , SINGH LUBHAN
Published: May 2024

Objective: This study focuses on the development and validation of a sensitive, simple, accurate, precise and cost-effective Ultraviolet-Visible (UV) spectrophotometric method for the quantification of Linezolid, a widely used antibiotic in pharmaceutical formulations.
Methods: The analysis utilized a solvent system comprising 80% water and 20% methanol (v/v). The absorbance of standard solutions was measured and a calibration curve was constructed. Various analytical performance parameters, including linearity, range, precision, accuracy, Limit of Detection (LOD), Limit of Quantification (LOQ) and ruggedness, were determined following the International Conference on Harmonization (ICH) Q2 (R1) guidelines.
Results: The maximum absorption peak (λmax) of Linezolid was determined to be 251 nm in the selected medium. Beer-Lambert’s law was valid in the concentration range of 0.5–9 μg/ml, with a high correlation coefficient (R2) of 0.9955. The proposed method exhibited a recovery ranging from 99.08 to 100.37% with % Relative Standard Deviation (RSD) value consistently below 2%.
Conclusion: The study findings confirm the accuracy, precision and reproducibility of the developed method. Additionally, it is characterized by its simplicity, affordability, and time efficiency. Thus, this method can be effectively employed for the quantification of Linezolid in lipid nanoparticles.
A Study on the Learning Process and Evaluation Characteristics with High and Low Learning Effects: Focusing on the Experience of Prospective Instructors
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, YUN Ga-young
Published: May 2024

Objectives The purpose of this study is to explore the characteristics of instructions recognized as having a high learning effect and as having a low learning effect.
Methods For this purpose, we conducted written interviews using online platform with 18 prospective instructors who are experiencing the pre-instructor course at the graduate school of education. It was designed to focus on instructions experienced before, not on instructions currently being taken, and through this, the process and effect of learning could be reported more objectively. The collected qualitative data were analyzed using a thematic anal-ysis method, and the learning process of instructions with high learning effects and instructions with low learning effects were derived and presented in a diagram.
Results As a result of the study, 3 main categories, 9 themes, and 19 subcategories were derived as character-istics of the learning process included in instruction with high learning effect, and the amount of learning load, dif-ficulty, and responsibility perceived by learners were also confirmed along with the learning burden factors. As for the instruction with low learning effect, 3 main categories, 9 themes, and 18 subcategories were derived, and these included ‘no task’ and ‘no burden’. In the instruction with high learning effect, the focus of assignments and evaluations was on the learning process and performance, and improvement and feedback were made through the feedback of the instructor. In the instruction with low learning effect, the focus of assignments and evaluations was on organizing, summarizing, and general evaluation, and it was difficult to confirm improvement and feedback through instructor's feedback. Moreover, the difficulty and amount of learning load in the class were burden factors that appeared in both classes with high and low learning effects. Considering these results, instructors need to consider ways to have explanatory power to effectively deliver class content by analyzing learners' levels rather than reducing the difficulty and amount of learning.
Conclusions Based on these findings, recommendations were provided to guide professors in aiming for and de-signing effective instructions.
Development of character education program linked to elementary school curriculum using PDC
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim SeungSook , Kim Dugyu
Published: May 2024

Objectives The purpose of this study is to develop a character education program linked to the elementary school curriculum using positive classroom discipline.
Methods The research method used to conduct this study was the ADDIE model, a representative ISD model. A design strategy was derived through requirements analysis such as literature analysis, case analysis, and expert interviews, and a draft of the program based on the design strategy was developed. An expert formative evaluation was conducted using FGI. Based on the results of the expert formative evaluation the program was modified and supplemented to produce the final version of the program. The final version of the program was verified for validity in five categories.
Results The results of this study are as follows. First, a program design strategy was derived through literature analysis, case analysis, and needs analysis. Second, based on the program design strategy, a draft character edu-cation program using PDC was designed. Third, the final version of the program was derived through expert for-mative evaluation of the draft program. Fourth, as a result of verifying the program with a feasibility test tool, it was overall evaluated positively that the character education program using PDC had explanatory power, usefulness, validity, understanding, and universality.
Conclusions As a result of the above research, it is expected that the character education program linked to the elementary curriculum using PDC developed in this study will be a useful program that can be used immediately by teachers in elementary schools. However, since this program consists of content suitable for use in upper grades, it is necessary to develop a program for lower grades of elementary school with easier questions and activities.
A Study on Multicultural Learning Using Movies for College Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Hye Jeong
Published: May 2024

Objectives This study emphasizes the usefulness of various films for multicultural learning and analyzes learners' perceptions of multicultural education through movies.
Methods For this purpose, the research’s video media centered on Paddington, which helps pupils understand the process of adapting to other cultures, and Serial Bad Weddings, which highlights cultural differences between countries. The teaching procedure consisted of four stages: The cultural preparation stage, the cultural under-standing stage, the cultural organization stage, and the self-evaluation stage. Learners used a self-evaluation journal and responded to an open-ended questionnaire to determine their awareness and satisfaction with how cultural classes utilized films.
Results The result revealed that learners were delighted with cultural classes employing multicultural media (83.7%). Specifically, the students cited the usefulness of cultural learning, media use, fun, and participation ac-tivities for their high satisfaction levels.
Conclusions Task-oriented participatory activities using video media should be actively utilized during multi-cultural learning. Instructors should design participatory activities for multicultural education to engage learners.
Working Moms' Evaluative Concern Perfectionism and Job Burnout: The Mediating Role of Mindfulness
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim NA-RAE , Woo Young Jee
Published: May 2024

Objectives This study aimed to examine whether mindfulness mediates the relationship between evaluative con-cern perfectionism and job burnout among working moms
Methods For the research, an online survey was conducted with full-time working mothers with children under elementary school age, addressing evaluative concern perfectionism, job burnout, and mindfulness. A total of 250 responses were analyzed using SPSS 27.0 and AMOS 27.0.
Results The analysis revealed significant correlations among the key variables. Additionally, mindfulness was found to partially mediate the relationship between evaluative concern perfectionism and job burnout among working moms. The individual trait of evaluative concern perfectionism corresponds to job demands leading to burnout, and in such cases, mindfulness appears to play a role in mitigating maladaptive influences as a job resource.
Conclusions This implies that mindfulness, serving as a personality factor and a cognitive-behavioral intervention focus, plays a crucial role in addressing job burnout among working moms who exhibit perfectionistic tendencies. Finally, the implications and limitations of this study were discussed.
The Mediating Effect of Emotion Regulation and Worry on the Relationship between Mindfulness and Anxiety in Elementary School Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yang Gon Sung
Published: May 2024

Objectives This study aim to explore the relationship between mindfulness and anxiety and the mediating effects of emotion regulation and worry on the relationship between mindfulness and anxiety.
Methods The data were analyzed from 289 elementary school children in Seoul. Reliability analysis, technical sta-tistics, correlation analysis, and mediating effect analysis of each scale were conducted using the SPSS 18.0 and PROCESS Macro Model 4.2.
Results Research results were as follows. First, the correlation between mindfulness and anxiety were significant, and regression analysis showed that mindfulness significantly predicted anxiety. Second, the mediating effect of emotion regulation and worry were significant in the relationship between mindfulness and anxiety.
Conclusions This study was verified that children's mindfulness is a useful variable that directly affects anxiety re-duction and indirectly through emotional control and worry. It also provides useful information for making mindful-ness-based interventions. Considering the results that the indirect effect through worry was greater than the di-rect effect of mindfulness on anxiety, it suggests the need to include mindfulness activities on children's worry.
A Qualitative Study of the Impact of Dormitory Experiences on the College Life
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, YOO Hyeonjeong , CHO Mihye
Published: May 2024

Objectives This study examines the relationship between the formation of home experience in the dormitory and college life, based on qualitative interviews with college students about their living experiences in the dormitory.
Methods Ten college students who currently live or have lived in college dormitories were recruited as research participants, and the data collected through in-depth semi-structured interviews were analyzed from May 8, 2023 to August 15, 2023.
Results College students living in dormitories were found to view the dormitory as a public space for school rather than a private space for living and relaxing, and lacked ‘a sense of place/sense of IBASHO’. They reported that they were always aware of being watched and that this prevented them from relaxing fully. Residents tried to minimize the amount of time they spent in the dormitory, streamline their daily routines to avoid leaving their dorm rooms, or go home to relax when they were not in class, in an attempt to gain the time and space they felt they lacked. Instead, however, they failed to form an emotional connection to the dorm and viewed their time in the dorm as a time to endure. As a result, the students had difficulty adjusting to college life because they perceived their entire college experience as something to endure, and although they participated in the regular academic curriculum, they participated less in networking, socializing, and club activities.
Conclusions Based on the findings, this study recommends viewing the residential experience as part of a college education and expanding programs that build a sense of place in dormitories.
A narrative inquiry of the experience of a mother with adolescents participating in parental education based on emotional intelligence
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Choi Young-Jae , Kim Jeong-sook , Song Bo-young , Lee Myung-Woo
Published: May 2024

Objectives This study was conducted to explore in-depth the actual participation experience of a mother with adolescents participating in emotional intelligence-based parent education and the meaning of the experiences.
Methods To this end, emotional intelligence-based parent education was conducted from September to November 2023, and data were collected through face-to-face interviews three times by selecting one parent participant with adolescents. It was analyzed in the three-dimensional narrative inquiry’s space proposed by Clandinin & Connelly(2000) to interpret vivid experiences and their meanings in the context of the participant's life stories naturally and spontaneously.
Results There were 3 experience domains and 1 semantic domains and 15 lower categories. The first domain were ‘desperate desire to become an expert and be comfortable from a empty heart’ as the motivation. The sec-ond domain were ‘I'm afraid I'm going to be hurt’, ‘I'm desperate to fill my childhood parent position’, ‘the moment when a spark bursts while doing my best to play the role of a parent’, ‘mother constantly cracking down on me for fear of being told that I raised my child wrong’, ‘I'm living a hard life without a break and collapsing because of my emotions,’ and ‘I pretend to be okay outside and I'm acting like a comedian.’ The third domain were ‘the joy of warm support and care toward me’, ‘the courage to experience deep inner fears’, and ‘the person who grows into true self-understanding’.
Conclusions In the process of recognizing and understanding oneself, who unilaterally controlled and demanded change in relationships with children, it led to inner growth. The meaning of the participation experience in emo-tional intelligence parental education became an inflection point not only for the relationship with the children but also for the change in one's own growth through true meeting with oneself.
An Analysis of the Relationship between Technology Utilization Ability and Artificial Intelligence Education, Coding Education Perception of Pre-service Early Childhood Teachers
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, GO JEONGLEE
Published: May 2024

Objectives The purpose of this study is to empirically verify the relationship between technology utilization ability and awareness of artificial intelligence and coding education for pre-service early childhood teachers.
Methods For this purpose, a survey was conducted on 180 pre-service early childhood teachers majoring in child studies and early childhood education at a university located in J city, Gyeongsangnam-do, and the collected data were analyzed using SPSS program to verify reliability, mean comparison, and correlation analysis.
Results As for the difference in perception of research variables according to the demographic characteristics of pre-service early childhood teachers, pre-service early childhood teachers who completed information literacy education and had experience in artificial intelligence and coding education showed high level of perception of technology utilization ability and artificial intelligence and coding education. In addition, there was a significant positive correlation between technology utilization ability and the perception of artificial intelligence and coding education.
Conclusions In the era of the Fourth Industrial Revolution, early childhood teachers should cultivate information- related skills. Therefore, educational institutions that train early childhood teachers should actively review ways to strengthen education related to technology utilization education, artificial intelligence education, and coding education.