bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Approach to Polymer Flooding: Impact of the Early Polymer Injection and Wettability on Final Oil Recovery
Authors: Juarez-Morejon J. L. , Bertin H. , Omari A. , Hamon G. , Cottin C. , Morel D. , Romero C. , Bourdarot G.
Published: April 2018

An experimental study of polymer flooding is here presented focusing on the influence of initial core wettability and flood maturity (volume of water injected before polymer injection) on final oil recovery. Experiments were carried out using homogeneous Bentheimer sandstones of similar properties. The cores were oil flooded using mineral oil for water wet conditions, and with crude oil (after an ageing period) for intermediate wet conditions keeping constant in all experiments the viscosity ratio between oil and polymer solution. Polymer, which is a partially hydrolysed polyacrylamide (HPAM) was used at a concentration of 2500ppm in a moderate salinity brine. The polymer solution was injected in the core at different maturity times (0PV, Breakthrough, 1PV, 1.75PV, 2.5PV, 4PV and 6.5PV).

Coreflood results show that the maturity of polymer injection plays an important role on final oil recovery regardless wettability. The 0PV maturity (secondary polymer flooding) leads to the best sweep efficiency while final oil production decreases when the polymer flood maturity is high (late polymer injection after waterflooding). A difference of 15% in recovery is observed between secondary polymer flooding and late maturity (6.5 PV). Concerning the effect of wettability, the recovery factor obtained with water wet cores is always lower (from 10% to 20% depending on maturity) than the values obtained with intermediate wet cores, raising the importance of correctly restoring core wettability to obtain representative values of polymer incremental recovery. The influence of wettability can be explained by the oil phase distribution at the pore scale. Considering that the waterflooding period leads to different values of the oil saturation at which polymer flooding starts, we measured the core dispersivity using a tracer method at different states. The two-phase dispersivity decreases when water saturation increases which is favourable for polymer sweep.

This study shows that in addition to wettability, maturity of polymer flooding plays a dominant role in oil displacement efficiency. Final recovery is correlated to the dispersion value at which polymer flooding starts. The highest oil recovery is obtained when the polymer is injected early.
Economic Appraisal of Shale Gas Reservoirs
Authors: Kenomore Michael , Hassan Mohamed , Dhakal Hom , Shah Amjad
Published: April 2018

Natural gas produced from shale formations has increased rapidly in the past decade altering the oil and gas industry markets remarkably. The use of horizontal drilling and hydraulic fracturing has allowed previously unrecoverable shale gas to be extracted. Shale gas development is more expensive compared to conventional developments and as such, understanding the economic feasibility is of greater importance in successfully developing the resource. Using the estimated ultimate recoverable expressed in terms of P10, P50, and P90 from 2751 horizontal well production data (all starting production from 2008) from the Barnett shale, a discounted cash flow economic model (MS- Excel based) was used to quantify the effect of finding and development costs (F&DC) and gas prices on the economic viability of horizontal wells within four out of five basins (Strawn Basin, Ouachita Folded Belt, Forth-worth Syncline and Bendarch Basin) in the Barnett shale. The investment hurdle in the economic model was a rate of return of 20% and a payback period of 5 years or less. This paper helps determine the percentage of wells within basins in the Barnett shale that would be economically viable at various F&DC and gas prices subject to satisfying the prescribed investment hurdle.
Propagation to Reservoir Simulation of Uncertainty Associated with Three-Phase Relative Permeability Models with Hysteresis
Authors: Ranaee Ehsan , Inzoli Fabio , Riva Monica , Cominelli Alberto , Guadagnini Alberto
Published: April 2018

We study the way uncertainty associated with estimates of parameters of three-phase relative permeability models, including hysteresis, propagates to responses of reservoir simulations under Water Alternating Gas (WAG) conditions. We model three-phase relative permeabilities by: (i) joint calibration (on three-phase data) of a recent oil relative permeability model (Ranaee et al., 2015) and of the Larsen and Skauge (1998) gas relative permeability hysteretic model; and (ii) the common practice of relying on three-phase oil relative permeability models that are characterized solely on the basis of two-phase information (e.g., Stone, 1970 and Baker, 1988) in conjunction with the formulation of Larsen and Skauge (1998) for three-phase gas relative permeability. While model parameters associated with the former approach are linked to an estimation uncertainty, those of the models relying only on two-phase data are not. A numerical Monte Carlo (MC) framework is employed to estimate propagation to reservoir simulation outputs of uncertainty of parameters estimated through model calibration on three-phase data. Our findings suggest that evaluation of oil relative permeability through a saturation- weighted interpolation Baker model, even in combination with a three-phase gas relative permeability hysteresis model, yields the lowest values of field oil recovery. These are seen to lie outside uncertainty bounds evaluated via the above mentioned MC-based analysis. Relying on the Stone formulations together with the Larsen and Skauge (1998) gas relative permeability model yields (a) values of ultimate field oil recovery comprised within MC uncertainty bound and (b) values of field gas-oil ratio (GOR) which are smaller than those obtained through the Baker model in conjunction with the Larsen and Skauge (1998) formulation, both results falling markedly outside the MC-based confidence interval. Our results document the effect that propagation of uncertainties from calibrating three-phase relative permeability model parameters can have on field-scale simulation outputs, such as ultimate oil recovery and field GOR. They also serve as a baseline against which simulation results based on typical procedures to model three-phase relative permeabilities can be assessed.
The Modeling of the Viscous Drive in Oil-wet Naturally Fractured Reservoirs
Authors: Romero Rene , Behr Aron
Published: April 2018

Recent experiments have shown that gels can promulgate the viscous drive recovery mechanism in fractured oil-wet matrix cores. The large viscosity of gels can increase the pressure gradient in the fractured network, generating higher local pressures in the fractures that can overcome the capillary entrance pressure of the oil-wet matrix. When that occurs, the water leaking-off from the gel invades the matrix and displaces the oil to the fractures, promoting the viscous drive as the dominant recovery mechanism. The goal of this research is to comprehend whether the viscous drive recovery mechanism could enhance the oil recovery in oil-wet NFR under realistic conditions and furthermore to determine the range of applicability. The laboratory tests executed by Brattekås et al. (2013), where the gel was injected at high velocity in the fracture provoking matrix invasion, allowed generating a conceptual model of the process that was adapted in a numerical reservoir simulator to reproduce the experiments. As a step forward, the lab-scale simulations are scaled up to field conditions to analyze the phenomenon in real reservoirs. Multiple simulations were performed to evaluate the influence of different parameters such as the gel viscosity, the velocity of injection and the matrix block size on the recovery rate and the ultimate recovery factor. The simulation results demonstrated on the one hand that in smaller matrix blocks higher values of velocity-viscosity are needed to initiate the process, and additionally the capillary end-effect significantly affects oil production. On the other hand, in the larger matrix blocks the recovery time is considerably longer and could be unrealistic for practical applications. The dimensionless criterion controlling this process is derived as the viscous-capillary ratio relating the differential pressure along the fracture to the capillary pressure of the oil-wet matrix. To provoke the matrix invasion by the viscous drive, this dimensionless number should overcome a critical value which was estimated for this study. The novelty of this work has a significant contribution for the EOR implementation in oil-wet NFR. It is demonstrated that the viscous drive recovery mechanism can have a strong contribution on oil recovery.
Comprehensive Evaluation of the Dynamic Sealing Capacity of Clayey Caprocks in a Large Underground Gas Storage
Authors: Sun Junchang , Zheng Dewen , Wang Jieming , Liu Jiandong , Shi Lei , Xu Hongcheng , Li Chun , Zhong Rong , Zhao Kunshan
Published: April 2018

An effective caprock is crucial for safe operation of an underground gas storage (UGS). However, the caprock's initial seal capacity can be changed due to many factors such as micro-deformation of the caprock's pore structure and fatigue damage under cyclic loading caused by UGS annual storage which may all lead to gas leakage. Consequently, the caprock's dynamic sealing capacity including capillary sealing effciency and mechanical integrity under alternating stress must be comprehensively evaluated.

A total of 21 clayey caprock plugs drilled from the HB large UGS in western China were prepared to perform laboratory tests. Nitrogen breakthrough (BT) pressure was both measured before and after 50 cycles’ loading-unloading on the fully kerosene-saturated plugs. Specially, the cyclic amplitude was designed based on the UGS planned operational pressure bounds and local dynamic in-situ stresses. Triaxial compression fatigue and subsequent failure tests were conducted to investigate the strain dynamic evolution and its effect on the mechanical behaviors of clayey caprocks. Seventeen sandstone reservoir plugs were also selected to carry out mechanical tests as a comparison.

Experimental results indicate that the BT pressure of the HB caprock ranges from 3.88 to 8.79MPa which is much higher than the critical value (~2MPa) for the HB trap seal. Average reduction of the BT pressure is 14.8% after 50 cycles’ loading demonstrating that the alternating in-situ stresses may have a relatively minor effect on the capillary sealing capacity of the HB UGS caprock. This finding is also supported by the mechanical tests that the maximum cyclic loading is always below the yield point of the HB caprock. Compaction is the main deformation behavior and shear expansion has not occurred within the disturbed in-situ stresses variation during the HB UGS operations according to the dynamic evolution of the axial and lateral strain. However, the stress-strain curves exhibit significant hysteresis especially within the first several cycles and the plastic strain continuously develops. The average cumulative plastic strain is around 0.14% after 50 cycles’ loading which is much lower than the 1% benchmark of caprock failure suggested by Schlumberger. However, the cyclic loading has a more severe weakening effect on the caprock mechanical strength parameters and it cannot be neglected in geomechanical simulation compared with the sandstone reservoir plugs.

This study gives an in-depth understanding of the dynamic capillary sealing capacity and mechanical properties of the clayer caprocks under cyclic loading-unloading. Based on the above experimental finds, the more accurate evaluation will be obtained through 3D geomechanical model simulation.
Open Source Toolkit for Micro-Model Generation Using 3D Printing
Authors: Seers Thomas D. , Alyafei Nayef
Published: April 2018

Here, we present an open source toolkit for the generation of micro-fabricated transparent models of porous media (micro-models) from image datasets using optically transparent 3D polymer additive manufacturing (3D printing or sintering). These micro-models serve as both a research and pedagogical tool, facilitating the direct visualization of drainage and imbibition within quasi-2D porous media, generated from a range of image modalities (e.g. thin section micrographs, μCT orthoslices, and conventional digital photography).

Written in the MATLAB™ language and readily extendible, this open source toolkit is intended to act as enabler for community research for the study of transport in a porous media. In this work, we demonstrate the toolkit's capabilities using X-ray micro-tomographic image data. Orthoslices of scanned rocks (Berea sandstone) are cropped and segmented (binarized), then used to generate watertight 3D meshes of micro-models, which are exported as stereolithography (.stl) files: a native format to most commercially available 3D printers. The generated models are self-contained, with the inlet-outlet ports, synthetic rock matrix and transparent viewing panels printed as a single integrated unit.

The open source toolkit presented here offers a more accessible and adaptive approach to micromodel fabrication, when compared to conventional etched/molded equivalents, which require highly specialized manufacturing facilities. We suggest that the availability of such a toolset will act as a major enabler for community research in porous media transport phenomena, allowing experimental quasi-2D pore networks to be generated rapidly and cost effectively using readily available additive manufacturing technologies.
Reservoir and Economic Uncertainties Assessment for Recovery Strategy Selection: Use of Stochastic Decision Trees
Authors: Vincent Philippe , Schaaf Thomas
Published: April 2018

The field development phase prior to investment sanction is characterized by relatively large uncertainties at the time important decisions have to be made. It is, for instance, crucial to select an appropriate recovery strategy (depletion or injection) to obtain optimal hydrocarbon cumulative production whilst ensuring good profitability of the project. Evaluation of reservoir as well as economic uncertainties and quantification of their impact are needed before the field development concept selection.

This paper describes how to stochastically assess reservoir and economic uncertainties and the screening process used to select the best recovery strategy. The chosen methodology is the combination of uncertainty studies, including both continuous, discrete and controllable parameters. The different screened scenarios are combined in a stochastic decision tree, built-up through decision and chance nodes, to establish a distribution of recoverable volumes and rank the recovery strategies given a chosen criterion. A second uncertainty study is performed by adding economic uncertainties to the initial set of reservoir uncertain parameters. Eventually a new decision tree is established and scenarios ranked using economic criteria.

The application of this methodology to an oil field from the Norwegian continental shelf and how recovery strategies are ranked are presented in this paper. The described methodology has exhibited the risks and uncertainties carried by the project, as it was possible to rank the different solutions based on the dispersion of the recoverable volumes distribution and/or on the net present value (NPV). In the context of a marginal or large capex project, a robust P90 case is required and this may therefore influence the choice of the recovery strategy. For instance, a scenario yielding the largest hydrocarbon volume may not be selected because it requires too many wells and/or too large investment if one of these criteria is defined as the most important. In addition, the combination of uncertainty studies enabled a full economic evaluation covering the entire recoverable volumes distribution whereas in many projects economic evaluation is focused on the P90, Mean and P10 scenarios.

The two-step integrated approach allows a decision to be made whilst taking into account both reservoir and economic aspects. Having a combined stochastic approach to the reservoir and economic uncertainties avoids a biased decision. All cases are stochastically covered and screened using a systematic and unified methodology that gives the same weight to each scenario.
A New Method for Economic Prediction of Carbonate Reservoirs Based on Expert Library and Small Database
Authors: Chen Wenbin , Jiang Hanqiao , Li Junjian , Jiang Shan , Yang Hanxu , Qiao Yan
Published: April 2018

The karst caves and fractures are widely developed in carbonate reservoirs, which results in strong spatial heterogeneity. So the parameters obtained from its cores and numerical simulation are limited to reflect its production situation of the entire reservoir, which causes that the traditional economic prediction method for carbonate reservoirs has a high risk. To solve these problems, this paper proposes a new method to accomplish the economic prediction based on expert library and oilfield database, named Delphi-AHP-TOPSIS-MLS-FNPV complex algorithm (DATMF). DATMF method can take account of geological factors, such as sedimentary facies, reservoir types, the characteristics and heterogeneity of caves and fractures. It also considered the impact of production factors on the economic prediction, such as oil production, annual decline rate of production, well spacing density. The process of the DATMF method is as follows: First, establishing a set of hierarchical structure to describe the carbonate reservoirs in the database; Secondly, optimizing the database and analyzing the data based on the expert library; Thirdly, predicting the key development parameters of the new reservoir according to its geological data; Finally, substituting these parameters into the future net present value (FNPV) method to complete the economic prediction of the new carbonate reservoir. Through the calculation example of T7-444CH reservoir, it is found that DATMF method can predict oil production, investment recovery period, and the future net present value, etc. quickly and accurately. On the one hand, it greatly reduces the time and money cost of using traditional economic prediction methods. On the other hand, comparing with the popular big data analysis method, it improves the data's quality and increases the result's professionalism and practicality by using experts’ experience to constraint data, which makes the DATMF method can work on the smaller database. It is very suitable for the DATMF method to be applied in the early or middle stage of oilfield information construction.
A Composite Transient Model for Multi-Fractured Horizontal Well in Tight Gas Reservoirs Based on Multi-Factor Effect
Authors: Cao Lina , Lu Lize , Li Xiaoping , Wang Hehua , He Wei , Deng Yong , Xu Bing , Jiang Liping
Published: April 2018

In low-permeability tight reservoirs, the natural gas transient flow is affected by multi-factor including stress-sensitivity, threshold pressure gradient, or both. This paper aims to synthetically study transient pressure response as well as transient rate behavior of a multi-fractured horizontal well in tight gas reservoirs. With the new mathematics model, the flow characteristics coupled with such multi-factor can be described.

The new composite seepage model of a line-sink incorporating both stress-sensitive permeability and threshold pressure gradient was established. Employing fractures discretization and superposition principle yielded the final model of a multi-fractured horizontal well. The model was semi-analytically solved by Pedrosa's transformation, perturbation theory, and integration transformation method. Not only pressure transient analysis, but also rate transient analysis are separately performed with relevant parameters.

A total of six flow periods can be divided according to the same standard of time stages for pressure type curves and rate type curves. It is found that stress-sensitivity results in upward tendencies in both of pressure and rate derivative curves reflecting larger pressure drop during intermediate and late flow regimes; threshold pressure gradient leads to more difficult fluid flow acting a steeper upwarping on pressure curve and downwarping on production rate curve. Finally the variation trend of the corresponding curve will be more apparent under the combined impact of stress-sensitivity and threshold pressure gradient. The research of this paper can provide some insights into well dynamic forecasting during exploiting such reservoirs, and contribute to establish the theoretical basic for transient analysis efficiently.
Pressure Detrending for Harmonic Pulse Test Data Preprocessing
Authors: Viberti Dario , Salina Borello Eloisa , Verga Francesca
Published: April 2018

Harmonic Pulse testing was developed as a form of well testing that can be applied during ongoing production or injection operations. A pulsed signal is superimposed to the background pressure trend thus no interruption of well and reservoir production is required before and during the test. The pulsed pressure and rate signal analysis is performed in the frequency domain; to this end, the pressure and the rate signals need to be decomposed into harmonic components. The derivative of the harmonic components in the frequency domain can then be analyzed similarly to a conventional well test. In practice the interpretability of the derivative of the harmonic components can be significantly improved if the pressure trend to which the pressure pulses are superimposed is removed, i.e. a detrending of the pressure data is performed prior to well test interpretation.

In the present paper, the results obtained after applying different detrending methodologies to pressure data recorded during pulse tests in different reservoir conditions are presented and discussed.

Analyses on synthetic test data proved that polynomial detrending is effective in removing the pressure trend induced by field depletion and constant well interference but cannot deal with transient effect related to preexisting rate history or ongoing production changes. Conversely, some of the detrending algorithms based on a heuristic approach are very effective to remove both. Moreover, detrended data can be further regularized by excluding anomalous cycles from the analysis, i.e. cycles that do not respect the designed test periodicity, such as in the case of well interference and/or temporary interruption of the pressure pulses during the execution of the test.

The adoption of an effective detrending strategy can considerably improve the quality of the pressure data obtained from harmonic pulse tests and thus the test interpretability. Therefore, it offers the possibility of overcoming the limitation of applicability due to the difficulty of imposing a regularly pulsing rate for the whole test duration (typically lasting several days). This makes harmonic pulse tests very attractive for well performance monitoring, as in gas storage fields.
A novel hybrid MCDM model for financial performance evaluation in Iran's food industry
Authors: Alimohammadlou Moslem , Bonyani Abbas
Published: April 2018

The use of financial ratios as the necessary information is considered as one of the noticeable issues for researchers to apply quantitative models for evaluating the performance of institutions. The reason for introducing these new approaches is that the financial ratios cannot individually provide a correct and adequate understanding of an institution’s performance. This study sought to propose a model for evaluating and ranking 14 companies which are considered as the largest companies in Iran’s food industry according to the recent report of Industrial Management institute (IMI). To accomplish this, an integrated model composed of Best-Worst method and PROMETHEE II was used. Results of data analysis revealed that in final evaluation, some companies such as NOOSH MAZAN Co., PYAZR AI Co. and PEGAH ESF Co had higher positions compared to the others.
AVALIAÇÃO DA CAPACIDADE DOS PROCESSOS DE GOVERNANÇA CORPORATIVA DE TI BASEADA NO COBIT 5
Authors: Santos Diana Leite Nunes dos , Souza Neto João
Published: April 2018

O COBIT 5 traz a separação dos processos de governança e gerenciamento e uma nova abordagem de avaliação com foco na capacidade dos processos.  Esse artigo descreve a aplicação deste tipo de avaliação em uma instituição governamental brasileira, que resultou em 40% dos processos de governança no nível 0 – processo incompleto, e 60% no nível 1 - processo executado.  Dado o papel da governança, fragilidades em seus processos podem refletir negativamente no gerenciamento da TI da instituição e pesquisas adicionais devem incluir um aprofundamento neste relacionamento. Para esta instituição, em particular, é esperado que todos os processos de governança passem a ser executados (nível 1) nos próximos dois anos, que é um objetivo no rumo de um sistema de governança eficiente e eficaz.  As seguintes barreiras na aplicação desta auto-avaliação foram encontradas: falta de conhecimento dos processos do COBIT 5 por parte da instituição avaliada e extensão do questionário, que chegou a 33 perguntas em sua versão final. Quando comparado com o modelo de avaliação do COBIT 4.1, os resultados foram inferiores, com a mesma organização sendo classificada no nível 2 – repetível mas intuitivo, . O modelo anterior é também mais rápido e fácil de aplicar. Essa comparação deve ser feita com cuidado já que os modelos são muito diferentes em seu desenho e uso. Finalmente, os objetivos propostos foram alcançados: o mecanismo é repetível e pode ser usado futuramente para criar uma base histórica; ele pode ser aplicado como uma auto-avaliação e é esperado que seja completado, numa instituição com uma área de TI de médio porte, em até quatro horas.
Enhanced nitrogen removal and energy saving in a microalgal–bacterial consortium treating real municipal wastewater
Authors: Foladori P. , Petrini S. , Nessenzia M. , Andreottola G.
Published: April 2018

The optimization of total nitrogen removal from municipal wastewater was investigated in a laboratory-scale photo-sequencing batch reactor (PSBR) operated with a mixed microalgal–bacterial consortium spontaneously acclimatized to real wastewater. No external aeration was provided in the PSBR to reduce energy consumption: oxygen was only supplied by the microalgal photosynthesis. The enhancement of total nitrogen removal was achieved through: (1) feeding of wastewater in the dark phase to provide readily biodegradable COD when oxygen was not produced, promoting denitrification; (2) intermittent use of the mixer to favor simultaneous nitrification–denitrification inside the dense flocs and to achieve 41% energy saving with respect to continuous mixing. Efficient COD removal (86 ± 2%) was observed, obtaining average effluent concentrations of 37 mg/L and 22 mg/L of total COD and soluble COD, respectively. TKN removal was 97 ± 3%, with an average effluent concentration of 0.5 ± 0.7 mg NH4+-N/L. Assimilation of nitrogen by heterotrophic bacteria accounted only for 20% of TKN removal, whilst the major part of TKN was nitrified. In particular, the nitrification rate was 1.9 mgN L−1 h−1 (specific rate 2.4 mgN gTSS−1 h−1), measured with dissolved oxygen near zero, when the oxygen demand was higher than the oxygen produced by photosynthesis. Total nitrogen of 6.3 ± 4.4 mgN/L was measured in the effluent after PSBR optimization.
99mTc-labeled Small Molecules for Diagnosis of Alzheimer’s Disease: Past, Recent and Future Perspectives
Authors: Molavipordanjani Sajjad , Emami Saeed , Hosseinimehr Seyed Jalal
Published: April 2018

Background:

Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disease.
Its prominent hallmarks are extracellular deposition of β-amyloids (amyloid plaques), intracellular
neurofibrillary tangles (NTFs), neurodegeneration and finally loss of cognitive function. Hence, AD diagnosis
in the early stage and monitoring of the disease are of great importance.

Methods:

In this review article, we have reviewed recent efforts for design, synthesis and evaluation of
99mTc labeled small molecule for AD imaging purposes.

Results:

These small molecules include derivatives of Congo red, benzothiazole, benzofuran, benzoxazole,
naphthalene, biphenyl, chalcone, flavone, aurone, stilbene, curcumin, dibenzylideneacetone,
quinoxaline, etc. The different aspects of 99mTc-labeled small molecules including chemical structure,
their affinity toward amyloid plaques, BBB permeation and in vivo/vitro stability will be discussed.

Conclusion:

The findings of this review confirm the importance of 99mTc-labeled small molecules for AD
imaging. Future studies based on the pharmacophore of these designed compounds are needed for improvement
of these molecules for clinical application.
NAChR α4β2 Subtype and their Relation with Nicotine Addiction, Cognition, Depression and Hyperactivity Disorder
Authors: Laikowski Manuela M. , Reisdorfer Fávero , Moura Sidnei
Published: April 2018

Background:

Neuronal α4β2 nAChRs are receptors involved in the role of neurotransmitters regulation and release, and this ionic channel participates in biological process of memory, learning and attention. This work aims to review the structure and functioning of the α4β2 nAChR emphasizing its role in the treatment of associated diseases like nicotine addiction and underlying pathologies such as cognition, depression and attention-deficit hyperactivity disorder.

Methods:

The authors realized extensive bibliographic research using the descriptors “Nicotine Receptor α4β2” and “cognition”, “depression”, “attention-deficit hyperactivity disorder”, besides cross-references of the selected articles and after analysis of references in the specific literature.

Results:

As results, it was that found 179 relevant articles presenting the main molecules with affinity to nAChR α4β2 related to the cited diseases. The α4β2 nAChR subtype is a remarkable therapeutic target since this is the most abundant receptor in the central nervous system.

Conclusion:

In summary, this review presents perspectives on the pharmacology and therapeutic targeting of α4β2 nAChRs for the treatment of cognition and diseases like nicotine dependence, depression and attention-deficit hyperactivity disorder.
Immunometabolism in the Pathogenesis of Depressive Disorders - Therapeutic Considerations
Authors: Geisler Simon , Sperner-Unterweger Barbara , Fuchs Dietmar , Gostner Johanna M.
Published: April 2018

There exists a critical link between immunological processes and metabolic changes. Furthermore,
it becomes more and more evident that changes in immunometabolic pathways are highly interconnected
with psychological processes and the nervous system. Depressive disorders are a major
contributor to the overall burden of disease worldwide. Despite extensive research, therapeutic interventions
are often not satisfying. This may be due to the yet only partially elucidated pathobiochemistry
underlying the development of depression which may be influenced by multiple factors including genetics,
environment, lifestyle, and importantly by the immunological status. In this review article, the roles
and consequences of the interferon gamma-dependent pathways of tryptophan breakdown and neopterin
formation are discussed, as well as phenylalanine metabolism, trying to provide a rational link between
immunology, metabolism and mental status. Besides underlining the complexity of the mechanism involved
in the development of depression, the knowledge on relevant biomarkers may be useful in orchestrating
personalized therapy regimes.
ACP5: Its Structure, Distribution, Regulation and Novel Functions
Authors: Ren Xin , Shan Wen-Hua , Wei Lu-Lu , Gong Chan-Chan , Pei Dong-Sheng
Published: April 2018

Background:

Tartrate-resistant acid phosphatase 5 (ACP5) is an evolutionarily conserved and multifunctional
protein that is involved in generations of reactive oxygen species, normal bone development, osteoblast
regulation and macrophage function, affecting a series of pathways, as well as reflecting bone resorption
and osteoclast activity.

Methods:

Literature searches, systematic reviews and assessments about the structure, distribution, regulation
and novel functions of ACP5 were performed in this review from PubMed and Medline databases.

Results:

Studies demonstrate that RANKL can increase the expression of ACP5 through NFATc1 and c-Fos to
accelerate osteoclastogenesis, which also can be regulated by many regulators. Based on the aforementioned
information, it is shown that ACP5, together with the phosphatase activity, can medicate the progression and
development of human genetic diseases and cancer.

Conclusion:

As a novel target, ACP5 plays a critical role in preventing, monitoring and treating various kinds of
tumors, as well as accelerating the development of a promising therapeutic strategy for human genetic diseases.
However, the explicit mechanism between ACP5 and cancer is not so clear. It is necessary and significant for us
to pay more in-depth attention.
CoCrMo alloy vs. UHMWPE Particulate Implant Debris Induces Sex Dependent Aseptic Osteolysis Responses In Vivo using a Murine Model
Authors: Landgraeber Stefan , Samelko Lauryn , McAllister Kyron , Putz Sebastian , Jacobs Joshua.J. , Hallab Nadim James
Published: April 2018

Background:

The rate of revision for some designs of total hip replacements due to idiopathic aseptic loosening has been reported as higher for women. However, whether this is environmental or inherently sex-related is not clear.

Objective:

Can particle induced osteolysis be sex dependent? And if so, is this dependent on the type of implant debris (e.g. metalvspolymer)? The objective of this study was to test for material dependent inflammatory osteolysis that may be linked to sex using CoCrMo and implant grade conventional polyethylene (UHMWPE), using anin vivomurine calvaria model.

Methods:

Healthy 12 week old female and male C57BL/6J mice were treated with UHMWPE (1.0um ECD) or CoCrMo particles (0.9um ECD) or received sham surgery. Bone resorption was assessed by micro-computed tomography, histology and histomorphometry on day 12 post challenge.

Results:

Female mice that received CoCrMo particles showed significantly more inflammatory osteolysis and bone destruction compared to the females who received UHMWPE implant debris. Moreover, females challenged with CoCrMo particles exhibited 120% more inflammatory bone loss compared to males (p<0.01) challenged with CoCrMo implant debris (but this was not the case for UHMWPE particles).

Conclusion:

We demonstrated sex-specific differences in the amount of osteolysis resulting from CoCrMo particle challenge. This suggests osteo-immune responses to metal debris are preferentially higher in female compared to male mice, and supports the contention that there may be inherent sex related susceptibility to some types of implant debris.
Progressive Assessment of Ischemic Injury to White Matter Using Diffusion Tensor Imaging: A Preliminary Study of a Macaque Model of Stroke
Authors: Zhang Xiaodong , Yan Yumei , Tong Frank , Li Chun-Xia , Jones Benjamin , Wang Silun , Meng Yuguang , Muly E. Chris , Kempf Doty , Howell Leonard
Published: April 2018

Background:

Previous Diffusion Tensor Imaging (DTI) studies have demonstrated the temporal evolution of stroke injury in grey matter and white matter can be characterized by DTI indices. However, it still remains not fully understood how the DTI indices of white matter are altered progressively during the hyperacute (first 6 hours) and acute stage of stroke (≤ 1 week). In the present study, DTI was employed to characterize the temporal evolution of infarction and white matter injury after stroke insult using a macaque model with permanent ischemic occlusion.

Methods and materials:

Permanent middle cerebral artery (MCA) occlusion was induced in rhesus monkeys (n=4, 10-21 years old). The brain lesion was examined longitudinally with DTI during the hyperacute phase (2-6 hours, n=4), 48 hours (n=4) and 96 hours (n=3) post-occlusion.

Results:

Cortical infarction was seen in all animals. The Mean Diffusivity (MD) in lesion regions decreased substantially at the first time point (2 hours post stroke) (35%, p <0.05, compared to the contralateral side) and became pseudo-normalized at 96 hours. In contrast, evident FA reduction was seen at 48 hours (39%, p <0.10) post-stroke. MD reduction in white matter bundles of the lesion area was much less than that in the grey matter during the hyper-acute phase but significant change was observed 4 hours (4.2%, p < 0.05) post stroke . Also, MD pseudonormalisation was seen at 96 hours post stroke. There was a significant correlation between the temporal changes of MD in white matter bundles and those in whole lesion areas during the entire study period. Meanwhile, no obvious fractional anisotropy (FA) changes were seen during the hyper-acute phase in either the entire infarct region or white matter bundles. Significant FA alteration was observed in entire lesion areas and injured white matter bundles 48 and 96 hours post stroke. The stroke lesion in grey matter and white matter was validated by pathological findings.

Conclusion:

The temporal evolution of ischemic injury to the grey matter and white matter from 2 to 96 hours after stroke onset was characterized using a macaque model and DTI. Progressive MD changes in white matter bundles are seen from hyperacute phase to acute phase after permanent MCA occlusion and temporally correlated with the MD changes in entire infarction regions. MD reduction in white matter bundles is mild in comparison with that in the grey matter but significant and progressive, indicating it may be useful to detect early white matter degeneration after stroke.
46. zjazd Studiorum Novi Testamenti Societatis (1991)
Authors: Pisarek Stanisław
Published: April 2018

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175 lat Brytyjskiego i Zagranicznego Towarzystwa Biblijnego w Polsce
Authors: Chmiel Jerzy
Published: April 2018

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KS. BOGDAN PONIŻY, Reinterpretacja Wyjścia Izraelitów z Egiptu w ujęciu Księgi Mądrości, Poznań 1991
Authors: Dąbek Tomasz Maria
Published: April 2018

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Sesja poświęcona ks. J. Wujkowi w Wągrowcu (1991)
Authors: Bajko Stanisław
Published: April 2018

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Śp. ks. Konrad Marklowski (1912–1990)
Authors: Dreja Antoni
Published: April 2018

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Powrót do Boga i wspólnoty. Zadośćuczynienie za grzechy według Deutero-Izajasza i Księgi Psalmów
Authors: Witczyk Henryk
Published: April 2018

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Międzynarodowa sesja naukowa wykładowców liturgiki w Brixen (1992)
Authors: Boguniowski Józef Wacław
Published: April 2018

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Zadania Diecezjalnej Komisji do spraw Liturgii w świetle dokumentów Kościoła
Authors: Michałek Roman
Published: April 2018

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Świadek naszych czasów i wiary współczesnego Kościoła
Authors: Jaworski Marian
Published: April 2018

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Stary Testament a Boże dzieło zbawcze w Chrystusie (zagadnienie techniki hermeneutycznej w teologii św. Pawła)
Authors: Langkammer Hugolin
Published: April 2018

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RAYMOND E. BROWN, The Community of the Beloved Disciple. The Life, Loves, and Hates of an Individual Church in New Testament Times, New York–Ramsey–Toronto 1979
Authors: Mędala Stanisław
Published: April 2018

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KS. ZENON KALINOWSKI, Rozważania o św. Józefie, Warszawa 1979
Authors: Rumiński Stanisław
Published: April 2018

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Rodzaje literackie Sdz 6–8
Authors: Długosz Antoni
Published: April 2018

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Pontyfikał płocki z XII wieku
Authors: Podles Antoni
Published: April 2018

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Adoracja cudotwórcy – Mateuszowa interpretacja cudów Jezusa
Authors: Hergesel Tomasz
Published: April 2018

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Grzech, który sprowadza śmierć (1 J 5, 16)
Authors: Herrmann Teofil
Published: April 2018

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Krąg biblijny
Authors: Tomczyk Dominik
Published: April 2018

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KS. ADOLF ZIMMERMANN, Radujcie się. Kazania niedzielne i świąteczne na rok A, B i C, Poznań 1978
Authors: Rumiński Stanisław
Published: April 2018

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Sympozjum na temat inkulturacji na Uniwersytecie Salezjańskim w Rzymie (1983)
Authors: Strus Andrzej
Published: April 2018

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O. AUGUSTYN JANKOWSKI OSB, Zarys pneumatologii Nowego Testamentu, Kraków 1982
Authors: Chmiel Jerzy
Published: April 2018

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Ojciec Święty w Nowym Targu
Authors: Knabit Leon
Published: April 2018

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Tekst mszy i liturgii godzin na wspomnienie obowiązkowe błogosławionej Jadwigi królowej
Authors: Pro Sacramentis et Cultu Divino Sacra Congregatio
Published: April 2018

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Współczesna architektura sakralna w Irlandii
Authors: Stępień Piotr
Published: April 2018

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J. G. PLÖGER, H. J. WEBER (i inni), Der Diakon. Wiederentdeckung und Erneuerung seines Dienstes, Freiburg 1981
Authors: Stefański Jerzy
Published: April 2018

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Zmartwychwstanie Chrystusa przyczyną nadrzędną naszego odrodzenia wg 1 P 1, 3. 23
Authors: Hałas Stanisław
Published: April 2018

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Panorama współczesnej egzegezy Starego Testamentu. XI kongres IOSOT w Salamance 1983
Authors: Chmiel Jerzy
Published: April 2018

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Duchowość odkupienia środkiem odnowy Kościoła według encykliki „Redemptor hominis”
Authors: Nowak Stanisław
Published: April 2018

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K. H. SCHELKLE, Die Kraft des Wortes. Beiträge zu einer biblischen Theologie, Stuttgart 1983
Authors: Tomczyk Dominik
Published: April 2018

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Sprawozdanie z międzyseminaryjnego konkursu biblijnego
Authors: Herrmann Teofil
Published: April 2018

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KAZIMIERZ BUKOWSKI, Biblia a literatura polska. Antologia, Warszawa 1984
Authors: Biela Emil
Published: April 2018

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Biblistyka katolicka po Soborze Watykańskim II. W dwudziestolecie konst. dogm. „Dei Verbum” (1965–1985)
Authors: Chmiel Jerzy
Published: April 2018

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PIERRE MIREVAL, Lieux saints et pèlerinages d’Orient, Paris 1985
Authors: Nadolski Bogusław
Published: April 2018

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M. SQUARNEC, Vivere, credere, celebrare, Torino 1984
Authors: Stefański Jerzy
Published: April 2018

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La nuova proposta di iniziazione alla vita cristiana. Rito dell’iniziazione cristiana degli adulti. Teologia, liturgia, pastorale, Torino 1983
Authors: Stefański Jerzy
Published: April 2018

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ROBERT LE GALL, La liturgie, celebration de l’alliance, Chambray 1981
Authors: Nadolski Bogusław
Published: April 2018

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Napis w tunelu Siloe
Authors: Mendecki Norbert
Published: April 2018

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Święci Cyryl i Metody – twórcy Biblii słowiańskiej. Na kanwie encykliki Jana Pawła II „Slavorum Apostoli”
Authors: Chmiel Jerzy
Published: April 2018

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Historia oddziaływania tekstu (Wirkungsgeschichte) jako nowa metoda w badaniu Nowego Testamentu
Authors: Grzybek Stanisław
Published: April 2018

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List of Old Testament Peshitta Manuscripts edited by the Peshitta Institute, Leiden 1961
Authors: Woźniak Jerzy
Published: April 2018

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XXII sympozjum biblistów polskich – Tarnów 1985
Authors: Matras Tadeusz
Published: April 2018

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Konferencja syriologiczna w Lejdzie (1985)
Authors: Woźniak Jerzy
Published: April 2018

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Błogosławieństwa dziś i jutro
Authors: Mikołajczyk Marian
Published: April 2018

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Nowe tłumaczenia Biblii a teoria przekładu
Authors: Zaborski Andrzej
Published: April 2018

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LORENZO ALVAREZ VERDES CSSR, Caminar en el Espiritu. El pensamiento etico de S. Pablo, Roma 2000
Authors: Dziuba Andrzej F.
Published: April 2018

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Słowo Towarzystwa Biblijnego w Polsce na Święto Biblii 2002
Authors: Biblijne w Polsce Towarzystwo
Published: April 2018

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T. Witulski, Die Adressaten des Galaterbriefes. Untersuchungen zur Gemeinde von Antiochia ad Pisidiam, Göttingen 2000
Authors: Pindel Roman
Published: April 2018

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„Skąd zna on Pisma, skoro się nie uczył?” (J 7, 15)
Authors: Włodarczyk Stanisław
Published: April 2018

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Komputerowy program Bible Works – użyteczne narzędzie do badań biblijnych!
Authors: Hałas Stanisław
Published: April 2018

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Dar synostwa Bożego Jezusa (Łk 1, 32. 35)
Authors: Mikołajczak Mieczysław
Published: April 2018

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Komunikat Towarzystwa Biblijnego w Polsce
Authors: Biblijne w Polsce Towarzystwo
Published: April 2018

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Telegram Ojca Świętego
Authors: II Jan Paweł
Published: April 2018

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Proegzystencja chrześcijanina w ujęciu 2 Kor 5, 15
Authors: Jezierska Ewa Józefa
Published: April 2018

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XXV sympozjum biblistów polskich
Authors: Matras Tadeusz
Published: April 2018

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Teologia liturgii w ujęciu konstytucji „Sacrosanctum Concilium” i w całokształcie dzieła Soboru Watykańskiego II
Authors: Czerwik Stanisław
Published: April 2018

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Biblia i chrystologia
Authors: Biblijna Papieska Komisja
Published: April 2018

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Wymiar pneumatologiczny chrystologii
Authors: Jankowski Augustyn
Published: April 2018

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„Pan zaś jest Duchem” (2 Kor 3, 17)
Authors: Rubinkiewicz Ryszard
Published: April 2018

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Źródła polskich pieśni nabożnych
Authors: Wit Zbigniew
Published: April 2018

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O czytelności znaków. Refleksje z pogranicza semiotyki, sztuki kościelnej i liturgii
Authors: Chmiel Jerzy
Published: April 2018

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Vivre l’Eucharistie avec Marie,Paris 1981
Authors: Koperek Stefan
Published: April 2018

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Przekłady słowa „mysterion” w łacińskich tłumaczeniach biblijnych
Authors: Hoła Kazimierz
Published: April 2018

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KS. TADEUSZ LOSKA SJ, Bóg dla człowieka, Kraków 1981
Authors: Grzybek Stanisław
Published: April 2018

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„Ojcze nasz" Starego Testamentu. Analiza egzegetyczno-teologiczna tekstu Iz 63, 7–64, 11
Authors: Terlecka Barbara
Published: April 2018

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IV sesja plenarna Katolickiej Federacji Biblijnej (Bogota 1990)
Authors: Keler Konrad
Published: April 2018

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Pismo Święte w encyklice Jana Pawła II „Redemptoris Mater”
Authors: Langkammer Hugolin
Published: April 2018

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Biblijne pojęcie wolności
Authors: Jelonek Tomasz
Published: April 2018

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Książki nadesłane do redakcji
Authors: Matras Tadeusz
Published: April 2018

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Teologiczno-liturgiczne aspekty szabatu
Authors: Strycharz Edward
Published: April 2018

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Pieczęć królewskiego sługi
Authors: Dąbrowski Bogusław
Published: April 2018

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Egzegeza biblijna a filozofia
Authors: Chmiel Jerzy
Published: April 2018

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„Pięćdziesiątnica” i nazwy podobne
Authors: Breza Edward
Published: April 2018

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Symbolika ognia w Piśmie św.
Authors: Pytel Jan Kanty
Published: April 2018

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Problematyka życia rodzinnego w księdze Tobiasza
Authors: Grzybek Stanisław
Published: April 2018

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Prezbiter przewodniczący sprawowaniu liturgii – sakramentem Chrystusa w Duchu Świętym i w Kościele
Authors: Czerwik Stanisław
Published: April 2018

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Nowe aspekty biblijnej wizji małżeństwa i rodziny w adhortacji apostolskiej „Familiaris consortio”
Authors: Chmiel Jerzy
Published: April 2018

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Przegląd nowych atlasów biblijnych
Authors: Pisarek Stanisław
Published: April 2018

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Le Testament grec d’Abraham. Introduction, édition critique des deux recensions grecques, traduction par Francis Schmidt, Tübingen 1986
Authors: Wittlieb Marian
Published: April 2018

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O. Karol Van Oost i czasopismo „Misterium Christi”
Authors: Sczaniecki Paweł
Published: April 2018

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Człowiek Ośmiu Błogosławieństw: błogosławiony Piotr Jerzy Frassati (1901–1925)
Authors: Chmiel Jerzy
Published: April 2018

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Jak odbieramy nasze cierpienie? Próba aktualizacji tekstów biblijnych
Authors: Pilch John J.
Published: April 2018

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Uwagi o liturgicznej formacji seminarzystów i kapłanów
Authors: Fedorowicz Szymon
Published: April 2018

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A. JANKOWSKI, Przy stole słowa, 1: Adwent, Boże Narodzenie, Kraków 1998
Authors: Wronka Stanisław
Published: April 2018

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XXXV spotkanie naukowe wykładowców liturgiki w Polsce
Authors: Szczepaniec Stanisław
Published: April 2018

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O. Cyprian Vagaggini OSB i jego udział w dziele odnowy liturgii
Authors: Małaczyński Franciszek
Published: April 2018

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SIMON PHILIP DE VRIES, Obrzędy i symbole Żydów, przekł. z niderl. i oprac. A. Borowski, Kraków 1999
Authors: Chmiel Jerzy
Published: April 2018

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Ruch biblijny w Polsce
Authors: Smereka Władysław
Published: April 2018

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Ważny dokument
Authors: Jakubiec Czesław
Published: April 2018

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Nowy ewangeliarz polski z XVI wieku (ewangeliarz puławski)
Authors: Janów Jan
Published: April 2018

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O historiografii biblijnej i starowschodniej
Authors: Jelito Józef
Published: April 2018

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Uniwersytet Hebrajski w Jerozolimie
Authors: Jakubiec Czesław
Published: April 2018

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De profundis
Authors: Klawek Aleksy
Published: April 2018

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Słynny mariolog polski: o. Justyn Zapartowicz (Miechowita) O. P.
Authors: Węgrzyniak Tomasz
Published: April 2018

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Jak udostępnić ludowi udział w liturgii sakramentów świętych
Authors: Pielatowski Kazimierz
Published: April 2018

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Tradycje biblijne w Iranie
Authors: Machalski Franciszek
Published: April 2018

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Sprawy liturgiczne w XVI w. w diecezji krakowskiej
Authors: Długosz Teofil
Published: April 2018

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