bluuebunny/crossref_metadata_2025 huggingface dataset:
192 Health Equity Starts with Us: Recommendations from the Indiana Clinical and Translational Sciences Institute Racial Justice and Health Equity Task Force
Authors: Sotto-Santiago Sylk , Edmonds Brownsyne Tucker , Wiehe Sarah , Moe Sharon
Published: April 2022

OBJECTIVES/GOALS: The Indiana CTSI Strategy Committee charged the Racial Justice and Health Equity Taskforce to identify priorities with short-term and long-term goals consistent with the I-CTSI mission. In addition, I-CTSI leadership asked for a general description of current state and the resources necessary to achieve the proposed goals. METHODS/STUDY POPULATION: The Taskforce applied an inclusive excellence model to the way we look at the I-CTSI structure, policies, and programs while performing an environmental scan within and across I-CTSI partner institutions. In order to reach equitable solutions and consensus, listening tours were held with partner stakeholders guided by the SOAR framework for strategic planning. This approach allowed us to assess current resources, needs, and gaps across the system, along with a baseline of measures currently monitored. Taskforce members openly discussed strengths and opportunities for enhancement of current programs and services. In addition, these conversations offered an opportunity to disrupt existing practices and through collective agency we identified priority areas that promote equity, diversity and inclusion. RESULTS/ANTICIPATED RESULTS: The Taskforce identified recurring themes in conversations with all partners, which led to the formation of three working groups that examined recruitment broadly: workforce, staffing, and research participation; professional development across all stakeholders from community members to I-CTSI staff; and data-centered metrics informing current state, decision-making, and accountability. Recommendations included these priorities, content, and implementation strategies. The Taskforce delivered a report to the I-CTSI leadership fostering the promotion of diversity, equity and inclusion along with a systematic collection of gender, race, and ethnicity data for individuals utilizing I-CTSI services and resources requiring additional metrics and tracking. DISCUSSION/SIGNIFICANCE: The pandemic shed light on the manner in which marginalized groups are rendered particularly vulnerable to death and disease by systemic and structural racism. The I-CTSI recognized that we cannot advance population health without attending to root causes of inequity and that includes our internal structure. We offer a potential model for other CTSAs.
195 Older adults show biomarker evidence of PICS after sepsis
Authors: Mankowski Robert , Anton Stephen , Ghita Gabriela , Leeuwenburgh Christiaan , Moldawer Lyle , Efron Philip , Brakenridge Scott , Moore Frederick
Published: April 2022

OBJECTIVES/GOALS: Many older sepsis survivors develop chronic critical illness (CCI) with poor outcomes. Sepsis is caused by a dysregulated immune response and biomarkers reflecting PICS. The purpose was to compare serial PICS biomarkers in a) older (versus young) adults and b) older CCI (versus older RAP) patients to gain insight into underlying pathobiology of CCI. METHODS/STUDY POPULATION: Prospective longitudinal study with young (â‰¤ 45 years) and older (â‰¥ 65 years) septic adults who were characterized by a) baseline predisposition, b) hospital outcomes, c) serial SOFA organ dysfunction scores over 14 days, d) Zubrod Performance status at three, six and 12-month follow-up and e) mortality over 12 months. Serial blood samples over 14 days were analyzed for selected biomarkers reflecting PICS. RESULTS/ANTICIPATED RESULTS: Compared to the young, more older adults developed CCI (20% vs 42%) and had markedly worse serial SOFA scores, performance status and mortality over 12 months. Additionally, older (versus young) and older CCI (versus older RAP) patients had more persistent aberrations in biomarkers reflecting inflammation, immunosuppression, stress metabolism, lack of anabolism and anti-angiogenesis over 14 days after sepsis. DISCUSSION/SIGNIFICANCE: Older (versus young) and older CCI (versus older RAP) patient subgroups demonstrate early biomarker evidence of the underlying pathobiology of PICS. The population of older sepsis survivors is need of interventions to lower systemic inflammation and stimulate anabolism to prevent skeletal muscle wasting and disability.
Exact coherent structures in pipe flow in the presence of wall transpiration
Authors: Ozcakir O. , Hall P. , Blackburn H.M.
Published: April 2022

The linear instability of the flow in a pipe subjected to a wavelike transpiration velocity at the walls is considered. The fully nonlinear problem is formulated at high Reynolds numbers and small transpiration velocities. Solutions of the nonlinear system describing the bifurcation of disturbances caused by the transpiration are calculated and a complex bifurcation structure is uncovered with several nonlinear states possible at some transpiration amplitudes. The symmetries and structure of the nonlinear solutions are discussed.
Patrones de poblamiento del noroeste y centro-oeste de la Patagonia a partir del registro funerario y no funerario de cazadores-recolectores: Un modelo regional para los últimos 12.500 años
Authors: Rizzo Florencia
Published: April 2022

Se presenta un modelo teórico para abordar el poblamiento humano del noroeste y centro-oeste de la Patagonia (incluyendo ambas vertientes cordilleranas, en Argentina y Chile), a partir del análisis del registro funerario y no funerario de poblaciones cazadoras-recolectoras cuyas cronologías se extienden desde los últimos 12.500 años aP hasta el presente. Para su elaboración se consideró el modelo de poblamiento de la Patagonia planteado por Luis Borrero y los desarrollados por John Walthall y Gustavo Barrientos para el tratamiento y disposición de los muertos, y se tuvo en cuenta la ubicación de los contextos arqueológicos en los tipos de ambientes presentes (bosque/ecotono y estepa). Se definieron variables para caracterizar el registro funerario y no funerario, a partir de las que se identificaron las etapas del poblamiento humano. Los resultados sugieren que hay sectores dentro del área de investigación que presentan continuidad de ocupaciones humanas durante todo el período considerado, mientras que otros son ocupados de manera discontinua. En concordancia con esto, se manifiestan las distintas etapas de poblamiento. Este trabajo propone, en definitiva, un abordaje novedoso para el registro funerario y no funerario del área de investigación y la inserta dentro de la discusión regional del poblamiento humano de la Patagonia.
The 19th-century Slovak National Movement: Ethos of Plebeian Resistance
Authors: Gluchman Vasil
Published: April 2022

The author studies the 19th-century Slovak National Movement as a manifestation of the ethos of plebeian resistance against the “laws of progress” of the century in question, according to which small ethnic groups and nations were to be assimilated for the sake of the further development of more advanced nations and their cultures. A significant role in the formation of the ethos of plebeian resistance was played by Slovak folk culture, the historical context of Great Moravia, the solidarity and support of other Slavic nations living in the Habsburg monarchy, and, above all, the moral qualities of Slovak patriots. Among the most significant manifestations of this ethos was the codification of Slovak, which contributed to the formation of Slovak national identity and national ideology, the 1848–1849 Slovak Uprising, and the development of the Slovak national movement in the 1860s continuing into the mid-1870s. The aim of the 19th-century Slovak national movement was to achieve an equal position of the Slovak ethnic group among the other nations and ethnic groups living in the Habsburg monarchy, which would give rise to the free development of its creative powers and abilities as well as to the pursuit of ethical, humanistic ideals in the lives of its members.
Does Receiving Government Assistance Shape Political Attitudes? Evidence from Agricultural Producers
Authors: ANZIA SARAH F. , JARES JAKE ALTON , MALHOTRA NEIL
Published: April 2022

When individuals receive benefits from government programs, does it affect their attitudes toward those programs or toward government generally? A growing literature blends policy feedback theory and political behavior research to explore these questions, but so far it has focused almost exclusively on social policies such as the Affordable Care Act. In this article, we focus on a very different set of government programs that reach a more conservative, rural population: agricultural assistance. Our study ties administrative records on participation in USDA farm aid programs to an original, first-of-its-kind survey measuring agricultural producers’ political attitudes. We find that receiving agricultural assistance is sometimes related to producers’ views of the program delivering the benefits, but it depends on the divisiveness of the program and—for highly partisan programs—recipients’ ideology. However, receiving federal agricultural assistance is not associated with more positive views of government.
Einsteinian language: Max Talmey, Benjamin Lee Whorf and linguistic relativity
Authors: Gordin Michael D.
Published: April 2022

This paper explores the significant – albeit little-known – impact that physicist Albert Einstein's theory of relativity had on the development of the science of linguistics. Both Max Talmey, a physician who played a key role in the development of early twentieth-century constructed-language movements, and Benjamin Lee Whorf, who is closely associated with the notion of ‘linguistic relativity’, drew on their understanding of relativity to develop their ideas (and, in Talmey's case, also on his personal relationship with Einstein). Linguistic relativity, which posits that humans’ linguistic categories shape their perceptions of nature, has often been tied to ‘relativism’ in the social sciences and humanities. In contrast, Talmey's commitment to reformulating the language of Einsteinian relativity – especially through a constructed language he built in the 1920s and 1930s – emphasized the significance of ‘invariance’ simultaneously in the scientific doctrine and in the language in which it was discussed. The semiotic flexibility of Einstein's ‘relativity theory’ as it was widely (and wildly) appropriated outside the small community of theoretical physicists enabled the two opposing moves, while obscuring the historical linkage between physics and linguistics for both.
Role of fluids on deformation in mid-crustal shear zones, Raft River Mountains, Utah
Authors: Gottardi Raphaël , Hughes Brendan
Published: April 2022

Fluids are commonly invoked as the primary cause for weakening of detachment shear zones. However, fluid-related mechanisms such as pressure-solution, reaction-enhanced ductility, reaction softening and precipitation of phyllosilicates are not fully understood. Fluid-facilitated reaction and mass transport cause rheological weakening and strain localization, eventually leading to departure from failure laws derived in laboratory experiments. This study focuses on the Miocene Raft River detachment shear zone in northwestern Utah. The shear zone is localized in the Proterozoic Elba Quartzite, which unconformably overlies the Archaean basement, and consists of an alternating sequence of quartzite and muscovite-quartzite schist. In this study, we characterize fluid-related microstructures to constrain conditions that promoted brittle failure in a plastically deforming shear zone. Thin-section analyses reveal the presence of healed microcracks, transgranular fluid inclusion planes and grain boundary fluid inclusion clusters. Healed microcracks occur in three sets, one sub-perpendicular to the mylonitic foliation, and a set of two conjugate microcracks oriented at ∼40–60° to the mylonitic foliation. Healed microfractures are filled with quartz, which has a distinct fabric, suggesting that microcracks healed while the shear zone was still at conditions favourable for quartz crystal plasticity. Transgranular fluid inclusion planes also occur in three sets, similar in orientation to the healed microfractures. Fluid inclusions commonly decorate grain and subgrain boundaries as inter- and intragranular clusters. Our results document ductile overprint of brittle microstructures, suggesting that, during exhumation, the Raft River detachment shear zone crossed the brittle–ductile transition repeatedly, providing pathways for fluids to permeate through this shear zone.
Collateral Constraints, Financial Constraints, and Risk Management: Evidence From Anti-Recharacterization Laws
Authors: Fairhurst Douglas (DJ) , Nam Yoonsoo
Published: April 2022

We use the staggered enactment of anti-recharacterization laws as a plausibly exogenous shock to the value of securitizing collateral through special purpose vehicles (SPVs) and test how collateral values impact corporate risk management. Following the laws’ enactment, we find increases in commodity, foreign exchange, and interest rate hedging, especially for firms with exposure to these risks and that rely on SPVs. Supporting the collateral constraints literature, the effect is weaker for firms that likely need the collateral for external financing, such as financially constrained firms. Our findings highlight fluctuations in collateral values as an important consideration in risk management decisions.
European collaboration on health technology assessment: looking backward and forward
Authors: Ruether Alric , Imaz-Iglesia Iñaki , Bélorgey Chantal , Lo Scalzo Alessandra , Garrett Zoe , Guardian Marcus
Published: April 2022

The establishment of health technology assessment (HTA) has been an important topic in Europe for many years. There have been a series of activities starting with first projects in 1994 leading to joint actions from the European Network of HTA (EUnetHTA) ending in 2021. This long interval of engagement with HTA structures, methodology, and processes by all member states led to a reliable basis for European collaboration in HTA. This article shows milestones and developments from EUR-ASSESS in 1994 through the progress of EUnetHTA and the accompanying EU-HTA-Network up to the recent elaboration of the EU-HTA-Regulation. With the EU-HTA-Regulation HTA collaboration is taken out of the trial phase of more than 15 years. Through the previous EU HTA collaboration, the appreciation and understanding of the differences and complexities behind the HTA processes in the EU healthcare systems have improved. It is now necessary to make the final steps toward a sustainable European Network for HTA.
Mental disorder symptoms during the COVID-19 pandemic in Latin America – a systematic review and meta-analysis
Authors: Zhang Stephen X. , Batra Kavita , Xu Wen , Liu Tao , Dong Rebecca Kechen , Yin Allen , Delios Andrew Yilong , Chen Bryan Z. , Chen Richard Z. , Miller Saylor , Wan Xue , Ye Wenping , Chen Jiyao
Published: April 2022

Aims

There is a lack of evidence related to the prevalence of mental health symptoms as well as their heterogeneities during the coronavirus disease 2019 (COVID-19) pandemic in Latin America, a large area spanning the equator. The current study aims to provide meta-analytical evidence on mental health symptoms during COVID-19 among frontline healthcare workers, general healthcare workers, the general population and university students in Latin America.

Methods

Bibliographical databases, such asPubMed, Embase, Web of Science, PsycINFOandmedRxiv, were systematically searched to identify pertinent studies up to August 13, 2021. Two coders performed the screening using predefined eligibility criteria. Studies were assigned quality scores using the Mixed Methods Appraisal Tool. The double data extraction method was used to minimise data entry errors.

Results

A total of 62 studies with 196 950 participants in Latin America were identified. The pooled prevalence of anxiety, depression, distress and insomnia was 35%, 35%, 32% and 35%, respectively. There was a higher prevalence of mental health symptoms in South America compared to Central America (36%v. 28%,p< 0.001), in countries speaking Portuguese (40%)v.Spanish (30%). The pooled prevalence of mental health symptoms in the general population, general healthcare workers, frontline healthcare workers and students in Latin America was 37%, 34%, 33% and 45%, respectively.

Conclusions

The high yet heterogenous level of prevalence of mental health symptoms emphasises the need for appropriate identification of psychological interventions in Latin America.
Late Quaternary Slip Rate of the Zihong Shan Branch and Its Implications for Strain Partitioning Along the Haiyuan Fault, Northeastern Tibetan Plateau
Authors: Yao Wenqian , Liu‐Zeng Jing , Klinger Yann , Wang Zijun , Shao Yanxiu , Han Longfei , Wang Wei , Zhang Jinyu , Liu Zhijun
Published: April 2022

Geometrical complexities such as bends and branches are ubiquitous along strike‐slip faults. Understanding strain partitioning between the different fault strands along such sections is key to assessing kinematics and evolution through time of a fault system and related seismic hazards. The Haiyuan fault, one of the longest strike‐slip faults of the Tibetan Plateau, has developed a multi‐stranded complex fault geometry along the Hasi Shan restraining bend. In this study, we quantified the slip rate of the ∼50‐km‐long Zihong Shan fault, which is the poorly‐known southernmost fault strand of the Hasi Shan restraining bend. We computed high‐resolution DEMs and orthophotos to document the offset landforms along this fault using drone surveys. At selected sites with well‐preserved offset geomorphic markers, we quantified displaced terraces and channels using microtopography analysis. We dated the abandonment age of these terraces using 10Be cosmogenic depth profiles and OSL dating techniques. It yields a left‐lateral slip rate of 1.9 ± 0.6 mm/yr since ∼13 ka, which is similar to the rate of the main Hasi Shan branch that ruptured during the 1920 Haiyuan earthquake. The minimum total horizontal slip rate system summed over the multiple strands of the Haiyuan fault at the Hasi Shan restraining bend is 4.1 ± 0.6 mm/yr, without considering the vertical deformation rate of these fault strands. The rate is thus slightly smaller than, but comparable to, slip‐rates determined along the rest of the Haiyuan fault, east and west of the Hasi Shan restraining bend.
Three‐Dimensional Thermal Structure of East Asian Continental Lithosphere
Authors: Sun Yujun , Dong Shuwen , Wang Xueqiu , Liu Mian , Zhang Huai , Shi Yaolin
Published: April 2022

The thermal structure of East Asian continental lithosphere is critical for understanding its diffuse and variable intracontinental deformation in the Cenozoic. Here, we present a three‐dimensional model of the lithospheric thermal structure of East Asia, using the latest thermal conductivity and radiogenic heat production measurements in mainland China. The results show great lateral heterogeneity of lithospheric temperature. The crust of orogenic belts such as the Tibetan Plateau, the Mongolia Plateau, the Tian Shan orogen, and Northeast China, is generally characterized by high temperatures. Other regions of high crustal temperatures include the southeast coast of China and Lake Baikal. The heat sources for the crust also vary. In the Tibetan Plateau, high crustal temperatures result mainly from radiogenic heat production within the thick crust, indicating the influence of continental collision. However, high heat flow from the upper mantle is the main cause of high surface heat flow in the eastern part of East Asia, where the relatively thin lithosphere and hot asthenosphere is related to the subduction of the Pacific Plate. This subduction is also responsible for Cenozoic continental volcanoes in East Asia.
Saccharibacteria harness light energy using type-1 rhodopsins that may rely on retinal sourced from microbial hosts
Authors: Jaffe Alexander L , Konno Masae , Kawasaki Yuma , Kataoka Chihiro , Béjà Oded , Kandori Hideki , Inoue Keiichi , Banfield Jillian F
Published: April 2022

Microbial rhodopsins are a family of photoreceptive membrane proteins with a wide distribution across the Tree of Life. Within the candidate phyla radiation (CPR), a diverse group of putatively episymbiotic bacteria, the genetic potential to produce rhodopsins appears to be confined to a small clade of organisms from sunlit environments. Here, we characterize the metabolic context and biophysical features of Saccharibacteria Type-1 rhodopsin sequences derived from metagenomic surveys and show that these proteins function as outward proton pumps. This provides one of the only known mechanisms by which CPR can generate a proton gradient for ATP synthesis. These Saccharibacteria do not encode the genetic machinery to produce all-trans-retinal, the chromophore essential for rhodopsin function, but their rhodopsins are able to rapidly uptake this cofactor when provided in experimental assays. We found consistent evidence for the capacity to produce retinal from β-carotene in microorganisms co-occurring with Saccharibacteria, and this genetic potential was dominated by members of the Actinobacteria, which are known hosts of Saccharibacteria in other habitats. If Actinobacteria serve as hosts for Saccharibacteria in freshwater environments, exchange of retinal for use by rhodopsin may be a feature of their associations.
A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
Authors: Encinas Cristina , Hernandez-Rivas José-Ángel , Oriol Albert , Rosiñol Laura , Blanchard María-Jesús , Bellón José-María , García-Sanz Ramón , de la Rubia Javier , de la Guía Ana López , Jímenez-Ubieto Ana , Jarque Isidro , Iñigo Belén , Dourdil Victoria , de Arriba Felipe , Pérez-Ávila Clara Cuéllar , Gonzalez Yolanda , Hernández Miguel-Teodoro , Bargay Joan , Granell Miguel , Rodríguez-Otero Paula , Silvent Maialen , Cabrera Carmen , Rios Rafael , Alegre Adrián , Gironella Mercedes , Gonzalez Marta-Sonia , Sureda Anna , Sampol Antonia , Ocio Enrique M. , Krsnik Isabel , García Antonio , García-Mateo Aránzazu , Soler Joan-Alfons , Martín Jesús , Arguiñano José-María , Mateos María-Victoria , Bladé Joan , San-Miguel Jesús F. , Lahuerta Juan-José , Martínez-López Joaquín ,   GEM/PETHEMA (Grupo Español de Mieloma/Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study group
Published: April 2022

Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin ≤30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0–2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies.
Exploring racial disparities in treatment patterns and outcomes for patients with multiple myeloma using real world data
Authors: Maignan Kathleen , Fashoyin-Aje Lola A. , Torres Aracelis Z. , Fernandes Laura L. , Gwise Thomas , Baxi Shrujal B. , Roose James P. , Rivera Donna R. , Shen Yuan Li , Kluetz Paul G. , Gormley Nicole J.
Published: April 2022

This retrospective observational study evaluated racial disparities among Black and White patients with multiple myeloma (MM). We included patients from a longitudinal de-identified EHR-derived database who had ≥2 visits recorded on or after 1/1/2011, documented treatment, and race listed as White or Black. Black patients (n = 1172) were more likely female (54.8%/42.9%) and younger (<65 years, 40.8%/30.8%) than White patients (n = 4637). Unadjusted median real-world overall survival (rwOS) indexed to first-line of therapy (LOT) was 64.6 months (95% CI: 57.8–74.0) for Blacks and 54.5 months (95% CI: 50.9–56.2) for Whites. Adjusted rwOS estimates (for sex, age at index date, and practice type) to either first- (aHR = 0.94; 95% CI: 0.84–1.06) or second-LOT (aHR = 0.90; 95% CI: 0.77–1.05) were similar. Unadjusted derived response rate (dRR) during first-LOT was 84.8% (95% CI: 80.7–88.1) for Blacks and 86.9% (95% CI: 85.0–88.5) for Whites (odds ratio [OR] = 0.78 [95% CI: 0.57–1.10]); in second-LOT, 67.2% (95% CI: 58.4–75.0) for Blacks and 72.4% (95% CI: 68.1–76.3) for Whites (OR = 0.72 [95% CI: 0.46–1.13]). High representation of Black patients enabled this robust analysis, albeit with limitations inherent to the observational data source, the retrospective design, and the analytic use of newly derived endpoints requiring further validation.
Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/− trastuzumab in patients with breast cancer brain metastases
Authors: Page David B. , Beal Kathryn , Linch Stefanie N. , Spinelli Kateri J. , Rodine Micaela , Halpenny Darragh , Modi Shanu , Patil Sujata , Young Robert J. , Kaley Thomas , Merghoub Taha , Redmond David , Wong Phillip , Barker Christopher A. , Diab Adi , Norton Larry , McArthur Heather L.
Published: April 2022

Breast cancer brain metastases (BCBM) are a common and devastating complication of metastatic breast cancer with conventional systemic therapies demonstrating limited effectiveness. Consequently, radiotherapy (RT) ± surgery remains the cornerstone of BCBM management. Because preclinical and clinical evidence indicate that immune checkpoint blockade (ICB) may synergize with RT to promote systemic tumor regression, we explored the safety and efficacy of RT and concurrent tremelimumab-mediated cytotoxic T-lymphocyte associated protein 4 (CTLA-4) ICB with tremelimumab ± HER2-directed therapy with trastuzumab for BCBM. Eligible patients had BCBM indicated for brain RT. A Simon two-stage design was adopted to evaluate the efficacy of tremelimumab and RT in 20 patients with human epidermal growth factor receptor normal (HER2−) BCBM. The safety of concurrent RT, tremelimumab, and trastuzumab was evaluated in a cohort of 6 HER2+ patients. The primary endpoint was 12-week non-central nervous system (CNS) disease control rate (DCR). Secondary endpoints included safety, survival, and CNS response. Exploratory correlatives included characterization of peripheral blood immune responses among exceptional responders. Tremelimumab plus RT ± trastuzumab was tolerated with no treatment-related grade 4 adverse events reported. The 12-week non-CNS DCR was 10% (2/20) in the HER2− cohort and 33% (2/6) in the HER2+ cohort. One patient with HER2+ disease experienced a durable partial response with evidence of peripheral T-cell activation. Thus, tremelimumab and RT ± trastuzumab was tolerated. Although modest clinical activity was observed in the HER2- efficacy cohort, encouraging responses were observed in the HER2+ safety cohort. Consequently, a trial to determine efficacy in HER2+ BCBM is planned.

Clinical Trial Registration Number: NCT02563925.
Corrosion-induced hydrogen evolution, absorption, and cracking behaviors of ultra-high-strength galvanized and galvannealed steel sheets
Authors: Kim Sung Jin , Park Jin Sung , Jung Seung-Pill
Published: April 2022

Various experimental analyses on hydrogen evolution, absorption, and cracking behaviors were conducted to gain a fundamental understanding of the hydrogen embrittlement of ultrastrong steel sheets with galvanized (GI) and galvannealed (GA) coatings. The hydrogen evolution and absorption behaviors are controlled primarily by the potential differences between the coating and exposed steel substrate, and the corrosion-induced damage pattern of the coating. The higher absorption rate of hydrogen was more pronounced in corroded GI-coated steel caused by the larger cathodic polarization applied to the exposed substrate, and a more severe form of coating dissolution by aqueous corrosion in a 3.5% NaCl + 0.3% NH4SN solution. In contrast, the corrosive species can only penetrate through the pre-existing cracks in the brittle Fe-Zn intermetallic phases composed of the GA coating, and the driving force for hydrogen evolution becomes smaller. These result in significant differences in hydrogen penetration and cracking behaviors between the two coated ultrastrong steels.
Redefining the hypotheses driving Parkinson’s diseases research
Authors: Farrow Sophie L. , Cooper Antony A. , O’Sullivan Justin M.
Published: April 2022

Parkinson’s disease (PD) research has largely focused on the disease as a single entity centred on the development of neuronal pathology within the central nervous system. However, there is growing recognition that PD is not a single entity but instead reflects multiple diseases, in which different combinations of environmental, genetic and potential comorbid factors interact to direct individual disease trajectories. Moreover, an increasing body of recent research implicates peripheral tissues and non-neuronal cell types in the development of PD. These observations are consistent with the hypothesis that the initial causative changes for PD development need not occur in the central nervous system. Here, we discuss how the use of neuronal pathology as a shared, qualitative phenotype minimises insights into the possibility of multiple origins and aetiologies of PD. Furthermore, we discuss how considering PD as a single entity potentially impairs our understanding of the causative molecular mechanisms, approaches for patient stratification, identification of biomarkers, and the development of therapeutic approaches to PD. The clear consequence of there being distinct diseases that collectively form PD, is that there is no single biomarker or treatment for PD development or progression. We propose that diagnosis should shift away from the clinical definitions, towards biologically defined diseases that collectively form PD, to enable informative patient stratification. N-of-one type, clinical designs offer an unbiased, and agnostic approach to re-defining PD in terms of a group of many individual diseases.
Disorder-robust phase crystal in high-temperature superconductors stabilized by strong correlations
Authors: Chakraborty Debmalya , Löfwander Tomas , Fogelström Mikael , Black-Schaffer Annica M.
Published: April 2022

The simultaneous interplay of strong electron–electron correlations, topological zero-energy states, and disorder is yet an unexplored territory but of immense interest due to their inevitable presence in many materials. Copper oxide high-temperature superconductors (cuprates) with pair breaking edges host a flat band of topological zero-energy states, making them an ideal playground where strong correlations, topology, and disorder are strongly intertwined. Here we show that this interplay in cuprates generates a fully gapped ‘phase crystal’ state that breaks both translational and time-reversal invariance, characterized by a modulation of the d-wave superconducting phase co-existing with a modulating extended s-wave superconducting order. In contrast to conventional wisdom, we find that this phase crystal state is remarkably robust to omnipresent disorder, but only in the presence of strong correlations, thus giving a clear route to its experimental realization.
Quantum phase transition in a clean superconductor with repulsive dynamical interaction
Authors: Pimenov Dimitri , Chubukov Andrey V.
Published: April 2022

We consider a model of electrons at zero temperature, with a repulsive interaction which is a function of the energy transfer. Such an interaction can arise from the combination of electron–electron repulsion at high energies and the weaker electron–phonon attraction at low energies. As shown in previous works, superconductivity can develop despite the overall repulsion due to the energy dependence of the interaction, but the gap Δ(ω) must change sign at some (imaginary) frequency ω0 to counteract the repulsion. However, when the constant repulsive part of the interaction is increased, a quantum phase transition towards the normal state occurs. We show that, as the phase transition is approached, Δ and ω0 must vanish in a correlated way such that $$1/| \log [{{\Delta }}(0)]| \sim {\omega }_{0}^{2}$$

1
/
∣
log

[

Δ

(

0

)

]

∣
~

ω

0

2

. We discuss the behavior of phase fluctuations near this transition and show that the correlation between Δ(0) and ω0 locks the phase stiffness to a non-zero value.
A multi-modal open dataset for mental-disorder analysis
Authors: Cai Hanshu , Yuan Zhenqin , Gao Yiwen , Sun Shuting , Li Na , Tian Fuze , Xiao Han , Li Jianxiu , Yang Zhengwu , Li Xiaowei , Zhao Qinglin , Liu Zhenyu , Yao Zhijun , Yang Minqiang , Peng Hong , Zhu Jing , Zhang Xiaowei , Gao Guoping , Zheng Fang , Li Rui , Guo Zhihua , Ma Rong , Yang Jing , Zhang Lan , Hu Xiping , Li Yumin , Hu Bin
Published: April 2022

According to the WHO, the number of mental disorder patients, especially depression patients, has overgrown and become a leading contributor to the global burden of disease. With the rising of tools such as artificial intelligence, using physiological data to explore new possible physiological indicators of mental disorder and creating new applications for mental disorder diagnosis has become a new research hot topic. We present a multi-modal open dataset for mental-disorder analysis. The dataset includes EEG and recordings of spoken language data from clinically depressed patients and matching normal controls, who were carefully diagnosed and selected by professional psychiatrists in hospitals. The EEG dataset includes data collected using a traditional 128-electrodes mounted elastic cap and a wearable 3-electrode EEG collector for pervasive computing applications. The 128-electrodes EEG signals of 53 participants were recorded as both in resting state and while doing the Dot probe tasks; the 3-electrode EEG signals of 55 participants were recorded in resting-state; the audio data of 52 participants were recorded during interviewing, reading, and picture description.
Curation of a list of chemicals in biosolids from EPA National Sewage Sludge Surveys & Biennial Review Reports
Authors: Richman Tess , Arnold Elyssa , Williams Antony J.
Published: April 2022

Section 405(d) of the Clean Water Act requires the US Environmental Protection Agency to review sewage sludge regulations every two years to identify any additional pollutants that may occur in biosolids and to set regulations for pollutants identified in biosolids if sufficient scientific evidence shows they may harm human health or the environment. To date, EPA has conducted eight biennial reviews to identify chemical and microbial pollutants and three national sewage sludge surveys to identify pollutants and obtain concentration data for chemicals found in biosolids. Prior to 2021, there was inconsistent reporting of chemicals identified and EPA did not cumulatively track chemicals in biosolids. Through the efforts presented here, EPA produced a list of 726 chemicals and structure-based classes found in biosolids based on biennial reviews and national sewage sludge surveys. Summary statistics of concentration data are also reported for the 484 chemicals found in the three national sewage sludge surveys. The creation of the Biosolids List supports EPA in assessing the potential risk of chemical pollutants found in biosolids.
DOPAMAP, high-resolution images of dopamine 1 and 2 receptor expression in developing and adult mouse brains
Authors: Bjerke I. E. , Cullity E. R. , Kjelsberg K. , Charan K. M. , Leergaard T. B. , Kim J. H.
Published: April 2022

The dopaminergic system undergoes major reorganization during development, a period especially vulnerable to mental disorders. Forebrain neurons expressing dopamine 1 and 2 receptors (D1R and D2R, respectively) play a key role in this system. However, neuroanatomical information about the typical development of these neurons is sparse and scattered across publications investigating one or a few brain regions. We here present a public online collection of microscopic images of immunohistochemically stained serial sections from male and female mice at five stages of development (postnatal day 17 (P17), P25, P35, P49, and adult), showing the distribution of D1R and D2R expressing neurons across the forebrain. All images from adult brains are registered to the Allen Mouse brain Common Coordinate Framework, while images from P17-P35 age groups are registered to spatially modified atlas versions matching the morphology of young brains. This online resource provides microscopic visualization of the developing dopaminergic system in mice, which is suitable as a benchmark reference for performing new experiments and building computational models of the brain.
The ProkaBioDen database, a global database of benthic prokaryotic biomasses and densities in the marine realm
Authors: Stratmann Tanja
Published: April 2022

Benthic prokaryotes include Bacteria and Archaea and dominate densities of marine benthos. They play major roles in element cycles and heterotrophic, chemoautotrophic, and phototrophic carbon production. To understand how anthropogenic disturbances and climate change might affect these processes, better estimates of prokaryotic biomasses and densities are required. Hence, I developed the ProkaBioDen database, the largest open-access database of benthic prokaryotic biomasses and densities in marine surface sediments. In total, the database comprises 1,089 georeferenced benthic prokaryotic biomass and 1,875 density records extracted from 85 and 112 studies, respectively. I identified all references applying the procedures for systematic reviews and meta analyses and report prokaryotic biomasses as g C cm−3 sediment, g C g−1 sediment, and g C m−2. Density records are presented as cell cm−3 sediment, cell g−1 sediment/ sulfide/ vent precipitate, and cell m−2. This database should serve as reference to close sampling gaps in the future.
Long-term artificial selection of Hanwoo (Korean) cattle left genetic signatures for the breeding traits and has altered the genomic structure
Authors: Seo Dongwon , Lee Doo Ho , Jin Shil , Won Jung Il , Lim Dajeong , Park Mina , Kim Tae Hun , Lee Hak Kyo , Kim Sidong , Choi Inchul , Lee Jun Heon , Gondro Cedric , Lee Seung Hwan
Published: April 2022

Indigenous Korean breeds such as Hanwoo (Korean) cattle have adapted to their local environment during the past 5000 years. In the 1980s, the National Genetic Improvement Program was established to develop a modern economic breed for beef production in Korea through artificial selection. This process is thought to have altered the genomic structure of breeding traits over time. The detection of genetic variants under selection could help to elucidate the genetic mechanism of artificial selection in modern cattle breeds. Indigenous Hanwoo cattle have adapted in response to local natural and artificial selection during a 40-year breeding program. We analyzed genomic changes in the selection signatures of an unselected population (USP; n = 362) and a selected population (KPN; n = 667) of Hanwoo cattle. Genomic changes due to long-term artificial selection were identified using a genome-wide integrated haplotype score (iHS) and a genome-wide association study (GWAS). Signatures of recent selection were detected as positive (piHS > 6) or negative (piHS < –6) iHS scores spanning more than 46 related genes in KPN cattle, but none in USP cattle. A region adjacent to the PLAG1 gene was found to be under strong selection for carcass weight. The GWAS results also showed a selection signature on BTA14, but none on BTA13. Pathway and quantitative trait locus analysis results identified candidate genes related to energy metabolism, feed efficiency, and reproductive traits in Hanwoo cattle. Strong selection significantly altered Hanwoo cattle genome structural properties such as linkage disequilibrium (LD) and haplotypes through causal mutation for target traits. Haplotype changes of genome structure which are changes of ancestral allele to derived alleles due to selection were clearly identified on BTA13 and BTA14; however, the structure of the LD block was not clearly observed except BTA14. Thus, selection based on EBVs would be working very well in Hanwoo cattle breeding program appears to have been highly successful.
Identification of ubiquitin-specific protease 32 as an oncogene in glioblastoma and the underlying mechanisms
Authors: Chen Sifang , Chen Xi , Li Zhangyu , Mao Jianyao , Jiang Weichao , Zhu Zhi , Li Yukui , Jiang Zhengye , Zhao Wenpeng , Tan Guowei , Wang Zhanxiang
Published: April 2022

Glioblastoma (GBM) patients present poor prognosis. Deubiquitination by deubiquitinating enzymes (DUBs) is a critical process in cancer progression. Ubiquitin-specific proteases (USPs) constitute the largest sub-family of DUBs. Evaluate the role of USP32 in GBM progression and provide a potential target for GBM treatment. Clinical significance of USP32 was investigated using Gene Expression Omnibus databases. Effects of USP32 on cell growth and metastasis were studied in vitro and in vivo. Differentially expressive genes between USP32-knockdown U-87 MG cells and negative control cells were detected using RNA sequencing and used for Gene Ontology and Kyoto Encyclopedia of Genes and Genomic pathway enrichment analyses. Finally, RT-qPCR was used to validate the divergent expression of genes involved in the enriched pathways. USP32 was upregulated in GBM patients, being correlated to poor prognosis. USP32 downregulation inhibited cell growth and metastasis in vitro. Furthermore, USP32 knockdown inhibited tumorigenesis in vivo. In addition, UPS32 was identified as a crucial regulator in different pathways including cell cycle, cellular senescence, DNA replication, base excision repair, and mismatch repair pathways. USP32 acts as an oncogene in GBM through regulating several biological processes/pathways. It could be a potential target for GBM treatment.
A novel approach for audible acoustic quick response codes
Authors: Zhu Weijun , Gao Ziang , Wang Yiran
Published: April 2022

Compared to image-based quick response (QR) codes, acoustic QR codes have some advantages. However, an acoustic QR scanner cannot recognize an acoustic QR code at a distance of more than two meters from an acoustic QR announcer. To this end, we propose a new sort of acoustic QR code, called an audible acoustic QR code (AAQRC), which employs humanly audible sound to carry users’ information directly. First, a user’s string of characters is translated into a string of pitches. Then, the related algorithms convert the string of pitches into a playable audio file. As a result, an AAQRC is generated, consisting of the audio itself. AAQRC recognition is the opposite process of AAQRC generation. Compared with the existing approach for acoustic QR codes, the new method can recognize acoustic QR codes at a longer distance, even if there are obstacles between the AAQRC announcer and AAQRC scanner.
Development of an electrospun poly(ε-caprolactone)/collagen-based human amniotic membrane powder scaffold for culturing retinal pigment epithelial cells
Authors: Majidnia Elahe , Ahmadian Mehdi , Salehi Hossein , Amirpour Noushin
Published: April 2022

The common retinal diseases are age-related macular degeneration (AMD) and retinitis pigmentosa (RP). They are usually associated with the dysfunction of retinal pigment epithelial (RPE) cells and degeneration of underlying Bruch’s membrane. The RPE cell transplantation is the most promising therapeutic option to restore lost vision. This study aimed to construct an ultrathin porous fibrous film with properties similar to that of native Bruch’s membrane as carriers for the RPE cells. Human amniotic membrane powder (HAMP)/Polycaprolactone (PCL) scaffolds containing different concentrations of HAMP were fabricated by electrospinning technique. The results showed that with increasing the concentration of HAMP, the diameter of fibers increased. Moreover, hydrophilicity and degradation rate were improved from 119° to 92° and 14 to 56% after 28 days immersion in phosphate-buffered saline (PBS) solution, respectively. All scaffolds had a porosity above 85%. Proper cell adhesion was obtained one day after culture and no toxicity was observed. However, after seven days, the rate of growth and proliferation of ARPE-19 cells, a culture model of RPE, on the PCL-30HAMP scaffold (HAMP concentration in PCL 7.2% by weight) was higher compared to other scaffolds. These results indicated that PCL-30HAMP fibrous scaffold has a great potential to be used in retinal tissue engineering applications.
Unexpected content of kynurenine in mother’s milk and infant formulas
Authors: Marszalek-Grabska Marta , Stachniuk Anna , Iwaniak Paulina , Gawel Kinga , Sumara Agata , Kocki Tomasz , Fornal Emilia , Milart Paweł , Paluszkiewicz Piotr , Turski Waldemar
Published: April 2022

Mother’s milk is widely recommended as complete food for the offspring in earliest postnatal time. However, the knowledge about detailed composition and the physiological role of bioactive components of breast milk is incomplete. Therefore, the aim of our study was to determine the content of kynurenine (KYN) in human breast milk during lactation and to explore the effects exerted by intragastric KYN administration from birth to weaning on physical and psychomotor development of adult rats. We found that KYN is consistently present in human milk and its content gradually increased from day 4 to 28 after delivery and that it is present in commercial baby formulas in amounts noticeably exceeding its physiological range. Animal studies showed that KYN supplementation resulted in a marked elevation of absorptive surface of rat intestine and in enhanced expression of both, aryl hydrocarbon receptor and G protein-coupled receptor 35 in the intestinal tissue in rats. Moreover, we discovered that KYN administration from birth to weaning resulted in neurobehavioral changes in adult rats. Therefore, we postulate that further research is required to thoroughly understand the function of KYN in early developmental stages of mammals and to ensure the safety of its presence in baby food products.
Biodegradable cellulose nanocrystals hydrogels for removal of acid red 8 dye from aqueous solutions
Authors: Abdelaziz Radwa Mohamed , El-Maghraby Azza , Sadik Wagih Abdel-Alim , El-Demerdash Abdel-Ghaffar Maghraby , Fadl Eman Aly
Published: April 2022

Biodegradable cellulose nanocrystals hydrogels (CNCsH) were synthesized from cellulose nanocrystals (CNCs) which were prepared from office wastepaper (OWP) by a chemical crosslinking method using epicholorohydrin (ECH) as a cross-linker. CNCsH were tested for their swelling behavior and biodegradability and the point of zero charge had been determined. The ability of CNCsH for removing the Acid Red 8 (AR8) anionic dye from its aqueous solution was evaluated. The different parameters affecting removal of the dye, such as pH, initial concentration of dye, content of CNCs, temperature and adsorbent dosage were investigated. The optimum conditions for 68% removal efficiency were pH = 1, initial concentration of dye = 10 ppm, contact time = 105 min, CNCs content = 5% and CNCsH dosage = 0.5 g at 30 °C. The adsorption isotherms, kinetics, and thermodynamic parameters have been studied. The results showed an appropriate fit for Langmuir adsorption isotherm and pseudo-second order kinetics model with an adsorption capacity of 17.12 mg/g. According to the obtained values of thermodynamic parameters, the removal of Acid red 8 by CNCs hydrogels was exothermic spontaneous process.