bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience of training and certification in pediatric disciplines of students majoring in 222 “medicine” specialty
Authors: Volosovets O.P. , Naumenko O.M. , Tsymbaliuk R.S. , Kryvopustov S.P. , Grischenko N.V. , Mozyrska O.V. , Loginova I.O. , Shevtsova T.I. , Chernii O.F. , Saltanova S.D. , Kovalchuk O.L. , Kryvopustova M.V.
Published: November 2023

Certification of graduates of the Faculty of Medicine 2 of the National Medical University (NMU) in pediatric disciplines was conducted by the Department of Pediatrics 2 at the objective structured practical (clinical) exam 2 (OSP(C)E-2) station “Initial and resuscitation care to a newborn child” on the basis of the Educational and Scientific Center of Medical Simulations of the NMU. The methodology that we introduced in 2022 in the Medical Education journal was presented and approved at the methodical meeting of the heads of departments of pediatrics of higher education institutions of Ukraine during the Sidelnikov readings. The data of an anonymous survey of graduates demonstrated that most respondents (93.4 % of domestic and 91.9 % of foreign ones) were satisfied with the volume of the station and its practical orientation. The students noted that during preparation to exam, this particular model of the station allows them to master, when using mannequins, manipulations according to the algorithm of initial and resuscitation care to a newborn child, which can be useful under various circumstances in wartime conditions. Out of 338 students of the Faculty of Medicine 2, 303 (89.6 %) passed the OSP(C)E-2 exam with an “excellent” grade, 32 (9.4 %) with a “good” grade, and 3 (0.9 %) with a “satisfactory” grade. The issue of optimality and adequacy of assessing only the skills in initial and resuscitation care to a newborn child at the OSP(C)E-2 exam remained deba­table among teachers. This corresponds to the opinion of 8.1 % of domestic and 6.6 % of foreign students who believe that for perfection and objectivity of pediatric skills assessment, it would be desirable to introduce one more pediatric station for the OSP(C)E-2 exam with the involvement of a virtual a patient of a different age. Experience of certification in pediatric disciplines of higher education graduates majoring in 222 “medicine” specialty at the Bogomolets National Medical University, both teachers and students, testified to its effectiveness and objectivity in assessing the special competencies of graduates in providing resuscitation care to a newborn child.
Biliary sludge syndrome induced by cephalosporins in children: clinical and diagnostic markers, management
Authors: Berezna T.G. , Synoverska O.B. , Fomenko N.M.
Published: November 2023

Biliary sludge can occur when taking medicines (oral contraceptives, cephalosporins, octreotide, furosemide, clofibrate, morphine, calcium preparations, etc.). In particular, 30–40 % of ceftriaxone, which is widely used in pediatric inpatient practice, is excreted with bile, 5–15 % of all side effects of the drug are due to biliary sludge. The mechanism of ceftriaxone-associated biliary sludge is due to the fact that ceftriaxone competes with bilirubin for albumin, which induces an increase in unconjugated bilirubin in the blood. The drug enters the bile in the form of a divalent anion, binds to calcium in ceftriaxone-calcium complexes with inclusions of cholesterol monohydrate crystals and bilirubinate granules. In patients taking cephalosporins, when complaints from the gastrointestinal tract appear, ultrasound screening is mandatory. Children with a family history of gallstone disease and risk factors should undergo ultrasound screening on the 10th day and 1 month after treatment with cephalosporins, even in the absence of complaints. The administration of ursodeoxycholic acid leads to a significant regression of clinical symptoms of biliary sludge and objective ultrasound signs in 2/3 of children after 2 months.
Clinical case of diagnosis of left ventricular non-compaction in a child
Authors: Kryuchko T.O. , Tanianska S.M.
Published: November 2023

Diseases of cardiovascular system in children present an extremely urgent problem nowadays. According to the latest epidemiological studies, there has been an increase by almost 3.2 % in congenital heart disease in Ukrainian children over the past 20–30 years. Left ventricular non-compaction belongs to a group of unclassified cardiomyopathies with undetermined prevalence. At the same time, based on literature, this pathology is characterized by a late diagnosis and very high mortality. In the pathogenesis of the disease, structural changes in the myocardium occur during the embryonic stage, leading to its abnormal development. Left ventricular non-compaction is considered a genetically heterogenous disease, which is inherited in an autosomal dominant pattern. The article deals with a clinical case of diagnosis and management of a child with left ventricular non-compaction, which demonstrates to ge­neral practitioners, pediatricians, and pediatric cardiologists the algorithm for diagnosing and managing patients with a rare disease in order to make earlier diagnosis, prevent complications, and preserve patient’s life. The patient who has been suffered from pneumonia, complained of breathlessness and rapid fatigue during minor physical exertion was timely referred by the family doctor for consultation with a pediatric cardiologist. Laboratory and instrumental studies allowed to suspect a rare congenital heart disease — left ventricular non-compaction. Subsequently, the patient was regularly examined by cardiologists and cardiac surgeons, received protocol therapy, was registered in a state transplant registry, which allowed to wait for a donor with subsequent successful heart transplant surgery.
An Investigation into the Environmental and Human Health Implications of Microplastic Toxicity
Authors: Liu Xijing , Zheng Han , Li Haixiao , Chen Yong
Published: November 2023

The pervasive distribution of microplastics in the environment has become a global concern, with potential repercussions for human health, ecosystems, and biological toxicity. This review synthesizes current research on the environmental distribution, potential pathways of human exposure, and health implications of microplastics. We highlight the methodologies employed in quantifying and characterizing microplastics, as well as the toxicological assessments conducted in various biological matrices. Our findings indicate a significant correlation between microplastic exposure and adverse health outcomes, necessitating urgent policy interventions and further research.
El sujeto del feminismo en cuestión: la disputa con el feminismo ilustrado
Authors: Gil Silvia L.
Published: November 2023

El sujeto del feminismo es aún objeto de un debate importante en el pensamiento contemporáneo. En este artículo discuto con amplitud los argumentos filosóficos de la postura transexcluyente; en concreto, los del feminismo ilustrado español, los cuales han tenido cierto impacto en países de Latinoamérica, como México. Considero que este debate no sólo concierne a las mujeres porque pone en juego las posibilidades de emancipación en un momento de profunda crisis. Además, el tipo de sujeto que presupone esta postura contribuye a una noción de lo humano que, a mi juicio, debe cuestionarse. Argumento que las diferencias no son un límite para la política feminista, sino la base para construir un nuevo pacto por la vida.
Dosier: Debates filosóficos sobre el cuerpo sexuado
Authors: Guerrero Mc Manus Siobhan F.
Published: November 2023

Introducción al dosier: Debates Filosóficos sobre el cuerpo sexuado: identidades trans, sujetos políticos e inclusión
Railway Locomotive Shed Management System
Authors: Bansode Mrs. U. M. , Patel Parth , Singh Animesh
Published: November 2023

Railway Locomotive Management Systems (RLMS) represent a pioneering innovation in the railway industry, providing a comprehensive approach to locomotive and operational management. This abstract provides a succinct overview of RLMS, emphasizing its importance and core functions. RLMS is a sophisticated amalgamation of software and hardware solutions aimed at modernizing locomotive management within contemporary railway networks. It addresses essential aspects such as locomotive tracking, maintenance scheduling, fuel management, crew management, inventory control, and performance monitoring. Furthermore, it enhances safety with advanced safety systems, efficient communication protocols, and real-time decision-making capabilities. The primary goal of RLMS is to elevate efficiency and safety in railway operations. This is achieved through the optimization of locomotive performance, predictive maintenance to minimize downtime, and reduction in fuel consumption. It also plays a pivotal role in crew management, ensuring well-trained staff and efficient scheduling
Design and Development of Low Cost Automated Ration System Using IOT
Authors: Kadu Prof. Anil , Nadaf Sumaiyya , Pajgade Medhavi , Narwane Mrunal , Nile Anjali
Published: November 2023

Abstract: The Automated Ration Distribution System (ARDS) is a state-of-the-art technological system designed to improve the efficiency, fairness, and accuracy of ration distribution. The ARDS combines artificial intelligence, machine learning, and data analytics to automate the distribution process, lower errors, and ensure equitable access toessential food supplies. Among the primary characteristics are user-friendly interface, data analysis, biometric verification, and intelligentinventory management. The technology facilitates data-driven decision-making, optimizes resource distribution, lowers shortages, detects andeliminates fraud. By fostering fair access to essential goods and promoting transparency in the allocation of rations, the ARDS has the potential to revolutionize rationing, particularly in crisis- affected areas.
The Impact of Artificial Intelligence on Employment and Workforce Trends in the Post-Pandemic Era
Authors: Pavashe Abhijit Sudam , Kadam Prathmesh Dashrath , Zirange Vinayak Bhairavanath , Katkar Rishikesh Dadaso
Published: November 2023

Abstract: The integration of artificial intelligence (AI) into the workforce has taken canter stage, accelerated by the COVID-19 pandemic and the imperative for remote and efficient work solutions. This research paper extensively examines the multifaceted impact of AI on employment and workforce trends in the post-pandemic era. Our study investigates the profound changes AI brings to the labour market, touching on issues such as job displacement, skills adaptation, and the evolving nature of work. Furthermore, we explore the ethical dimensions and socio-economic considerations of this transition. This paper offers a global perspective on how AI-driven workforce changes affect diverse regions and economies. Finally, it outlines strategies and recommendations for individuals and organizations to navigate this evolving landscape, ensuring a harmonious blend of AI technologies with human potential. The first dimension of this research is a prospective analysis of the current and future landscape. "Artificial Intelligence, Pandemic, and Employment: A Prospective Analysis" by John A. Smith provides a comprehensive exploration of the potential effects of AI and the pandemic on employment. Smith identifies the key challenges and opportunities emerging from this convergence, offering insights into the ever-changing world of work. He emphasizes the need for proactive adaptation to maximize the benefits of AI and navigate the challenges brought about by the pandemic. The impact of AI technologies is not limited to workforce trends; it extends to the broader labour market dynamics. In "AI and Labor Market Shifts: Implications for Post-Pandemic Recovery" by David R. Johnson, the research focuses on the implications of AI on labour market shifts. Johnson underlines the necessity of adopting forward-looking policies to ensure a harmonious transition into a post-pandemic world driven by AI. The study argues for a balanced approach that accounts for potential job displacement and highlights the importance of re-skilling and up-skilling initiatives.
Parental Perceptions during Paediatric Dentistry Treatments
Authors: S Dr. Gaurav Kumar
Published: November 2023

Background: Parental perceptions play a vital role in shaping the experiences of children during pediatric dentistry treatments. Understanding these perceptions is essential for improving the quality of care and reducing dental anxiety in both parents and children. Methods: A survey was conducted with 50 parents visiting Thai Moogambigai dental college for their children's dental treatments. The study explored parental perceptions, attitudes, and concerns regarding pediatric dentistry, as well as their trust in dental professionals.
Role of Microfinance on Women Empowerment in Siddharth District of U.P
Authors: Maurya Shiv Kumar , Babu Dr. Deepak
Published: November 2023

Abstract: A large portion of the population currently lives below the poverty line (BPL), which is a problem for emerging nations. Microfinance can aid developing nations in overcoming their poverty issues. Micro-finance offers a variety of financial resources (such as loans, insurance, savings, etc.) to the underprivileged so they can stabilize their businesses. Individuals can use these resources for a wide range of purposes, including pursuing business possibilities, raising their standard of living, paying off other sizable debts, responding to emergencies, etc. Microfinance is the arrangement of financial services including loans, savings, insurance, money transfers and remittances offered to the lower income groups or poor entrepreneurs, who otherwise cannot avail the standard banking services. The motive behind Microfinance is to give people in poverty a privilege to become self-sufficient by offering them crucial banking services at considerable smaller monetary amounts.
Orchard Mapping with Deep Learning Semantic Segmentation
Authors: Kumbhar Avadhut Shankar Salavi , Patil Prof. Mrs. S.S.
Published: November 2023

Abstract: The goal of orchard mapping with deep learning semantic segmentation is to automatic detection and localization of the orchard tree canopy under varied situations like multiple seasons, various tree ages, and varying levels of weed covering. The accuracy of segmentation depends on many factors like season, canopy size, and presence of weeds, background soil condition, and untreated soil. The proposed research have several combinations of training & test data based on orchard conditions The proposed research work contains deep learning convolutional neural network variant. The algorithm U- net network will be used. This helps to automatic detect and localize the tree canopy size using UAV images. Image segmentation will help all farmers by automatically segmenting tree canopies from aerial images for the development of integrated tools. After measurement of these parameters, tree canopy volume can be detected of targeted tree
Comparative Study of the Seismic Behaviour of G+20 Storey Building for Unsymmetrical Plan Area Using Light Weight Concrete and Normal Weight Concrete
Authors: Bhawsar Piyush , Pendharkar Dr. Umesh
Published: November 2023

Abstract: This research examines and compares the performance of structural lightweight concrete (SLWC) made with scoria and normal weight concrete (NWC), and normal and light weight concrete (NAL) in multi-storey buildings. A G+20 multi-storey unsymmetrical plan building is analysed using the response spectrum method with SLWC and NWC. Bending moment, shear force, storey shear, axial force, storey drift, and storey displacement are considered. The results show that SLWC can be used to reduce the weight of buildings without sacrificing strength or performance. This can lead to significant cost savings on construction and materials
CARGA IMEDIATA EM DENTES ANTERIORES
Authors: Branquinho Eric Dos Reis , Pereira Túlio Silva
Published: November 2023

Oral rehabilitation has advanced a lot in recent years aiming at the health, masticatory function and aesthetics of patients. This literature review summarizes current knowledge on immediate loading in healed and fresh sockets as their indications for clinical practice. From the interpretation of dental scientific data relevant to the topic, it can be said that there is evidence regarding the application and the time period that suggest that the protocols of immediate loading demonstrate high implant survival rates and can be recommended with caution for certain clinical situations. Immediate loading had similar clinical results compared to conventional loading and can be used as a successful treatment, as it has advantages such as reducing treatment time and providing early esthetics.
CONTRIBUIÇÃO DA ORTODONTIA CORRETIVA PREVIAMENTE AO TRATAMENTO REABILITADOR PROTÉTICO: revisão de literatura
Authors: Paula Ludmila Pires de , Silva Romes José da
Published: November 2023

Today's dentistry has increasingly sought treatments that involve a multidisciplinary approach to specialties. Therefore, orthodontics is the branch that deals with the prevention and correction of occlusal problems, acting in many cases in the pre-prosthetic treatment of patients. For this, the most used movements are, in general, extrusion, intrusion and verticalization. Thus, the justifications for this research consist of bringing updated information through a literature review, on the importance of multidisciplinary treatment in the rehabilitation of partially edentulous patients, with removable partial dentures, fixed prostheses or dental implants, correlating pre-prosthetic treatment with orthodontics. corrective. To this end, the general objective is to discuss the role of orthodontics in establishing a stable occlusion in patients who will undergo prosthetic rehabilitation. Specifically defining the advantages of orthodontics as an integral part of rehabilitative treatment, explaining the principles of malocclusion in partially edentulous patients. It is concluded, therefore, that there is a constant improvement in techniques and the possibility of success in the treatment of each patient. Intensive studies on mini implants are a factor of great importance in resolving cases requiring orthodontic adjustment. Therefore, orthodontic maneuvers, when planned before the prosthesis, can provide better hygiene, less plaque retention, elimination of unnecessary wear, correction of the occlusal relationship, distribution of occlusal forces, greater preservation of dental structures and better periodontal condition.
Understanding Sex Differences in Human Mortality Rates Through Tinbergen’s Four Questions
Authors: Kruger Daniel J. , Fitzgerald Carey J.
Published: November 2023

Sex differences in human mortality rates emerge from a complex interaction of genetic heritage and developmental environment. Although mortality is not in itself a behavior, it is an indirect product of behavior and physiology and thus responsive to life history variation in resource allocation, behavioral tendencies, and relevant environmental conditions. The explanatory framework of Tinbergenʹs Four Questions is sufficiently powerful in generalization to promote understanding of this phenomenon. Excess male mortality is a result of a trade‐off between competitiveness and longevity. Male life history gives greater emphasis to reproductive effort at the expense of somatic effort, and mating effort at the expense of longevity compared to female life history. Men exhibit riskier behavioral patterns and greater physiological susceptibility, dying at higher rates from behavioral and most non‐behavioral causes across the lifespan. The magnitude of the sex difference in mortality in developed nations peaks when males sexually mature and enter into mating competition. Social and environmental conditions intensifying male competition for resources, status, and mates lead to increased male mortality.
Síndrome hemofagocítico por mucormicosis en paciente pediátrico inmunocompetente. Reporte de caso
Authors: Samudio-Domínguez Gloria Celeste , Giménez Rolando , Ortega Natalia , Martínez Tamara , Aguilar Gustavo , Quintero Lorena , Celias Luis Fabián
Published: November 2023

El síndrome hemofagocítico secundario a mucormicosis en pacientes inmunocomptetentes es raro. La combinación de ambas entidades ocasiona alta mortalidad a pesar de esfuerzos médicos y quirúrgicos. La terapia antifúngica recomendada es la anfotericina B a altas dosis unida a un azol. Se recomienda medir sensibilidad del hongo para los diferentes anti fúngicos.
STRATEGI PEMBERDAYAAN MASYARAKAT MELALUI PROGRAM PENGELOLAAN SAMPAH DI BANK SAMPAH MAJU SELALU KELURAHAN MARUNDA JAKARTA UTARA
Authors: Stefany Indry , Rahmawati Isna
Published: November 2023

Abstract: Garbage is a problem that needs attention, there are people who do not understand the problem of waste and waste management. This problem is also found in the community of RW 05 Marunda Village. In waste management, most people rely on (PPSU) and paid waste officers. The existence of the Forward Always Garbage Bank is a solution in changing the community's lifestyle. This study aims to determine the strategy and results of community empowerment carried out by the Maju Selalu Waste Bank. In this study the methodology used was a qualitative approach with a descriptive. Data collection techniques were obtained by means of observation, interviews and documentation, the data sources of which were primary data and secondary data. Data analysis techniques through data reduction, data presentation and drawing conclusions. The empowerment strategy carried out by the Maju Selalu waste bank consists of forming groups, mentoring which is seen from the function of the Maju Selalu waste bank as a facilitator, communicator, and dynamicator. The results of the empowerment carried out can help the community meet their daily needs and increase community capacity in waste management. The results of empowerment can refer to the ability of people so that they have the ability to meet basic needs, increase income and participate in the empowerment process.Keywords: Empowerment Strategy; Garbage; Garbage Bank.Abstrak: Sampah merupakan masalah yang perlu diperhatikan, terdapat manusia kurang mengerti mengenai permasalahan sampah dan pengelolaan sampah. Permasalahan tersebut juga terdapat pada masyarakat RW 05 Kelurahan Marunda. Dalam pengelolaan sampah kebanyakan masyarakat mengandalkan (PPSU) dan petugas sampah berbayar. Adanya Bank Sampah Maju Selalu sebagai solusi dalam mengubah pola hidup masyarakat tersebut. Penelitian ini bertujuan untuk mengetahui strategi dan hasil pemberdayaan masyarakat yang dilakukan oleh Bank Sampah Maju Selalu. Pada penelitian ini metodologi yang digunakan yaitu pendekatan kualitatif dengan jenis deskriptif, teknik pengumpulan data diperoleh dengan cara observasi, wawancara dan dokumentasi yang sumber datanya berupa data primer dan data sekunder. Teknik analisis data melalui reduksi data, penyajian data dan penarikan kesimpulan. Strategi pemberdayaan yang dilakukan oleh Bank sampah Maju Selalu terdiri dari pembentukan kelompok, pendampingan yang dilihat dari fungsi Bank Sampah Maju Selalu sebagai fasilitator, komunikator, dinamisator. Serta strategi dalam perencanaan kegiatan. Hasil dari pemberdayaan yang dilakukan dapat membantu masyarakat dalam memenuhi kebutuhan sehari-hari dan meningkatkan kapasitas masyarakat dalam pengelolaan sampah. Adapun hasil dari pemberdayaan dapat merujuk pada kemampuan orang sehingga mereka memiliki kemampuan dalam memenuhi kebutuhan dasar, meningkatkan pendapatan dan berpartisipasi dalam proses pemberdayaan.Kata Kunci: Strategi Pemberdayaan; Sampah; Bank Sampah.
Novel Method for Identifying and Treating Erectile Dysfunction
Authors: Ajay Gupta Ram , Shiven Aditya
Published: November 2023

Sexual or erectile dysfunction (ED) is the ineptitude to get or keep a hard penile erection. ED can have a detrimentaleffect on physical and psychological health. This review helps in understanding the detailed etiology of ED and variousapproaches for the management of ED. The occurrence and incidence of erectile dysfunction are on the rise among men.Various other factors greatly impact the progression of ED, including individual general health and physiological conditions suchas psychiatric or psychological problems, diabetes mellitus, genitourinary disease, cardiovascular disease, and chronic diseases.Erectile dysfunction occurs when the release of nitric oxide (NO) triggers the activation of the guanylate cyclase enzyme in thespongiosum and corpora cavernosa, leading to relaxation of the vascular smooth muscle and an increase in cyclic guanosinemonophosphate (cGMP) levels. This physiological process is essential for achieving and maintaining a firm penile erection. Somecommon and advanced methods, such as the physical method, sexual history, laboratory testing, apomorphine test, NPTR test,and color duplex Doppler ultrasound test, are used to diagnose erectile dysfunction. This review also focuses on emergingtreatments that address the medical need for effective ED management. This comprehensive review bridges gaps in the currentliterature, offering superior insights into ED management and improving the quality of life for individuals with ED.
ANALISIS FUNGSI KORELASI KLASIK DAN KUANTUM UNTUK MODEL CINCIN: SEBUAH REVIEW
Authors: Ningsih P. A. Sunaryo Ayu , F. Lalus Herry , Yudhawardana Hartoyo
Published: November 2023

A review of the journal entitled 'Classical And Quantum Correlation Functions For A Ring Model' has been carried out which discusses the solutions of classical and quantum correlation functions for the ring model. Classical and quantum correlation functions are derived for systems of non-interacting particles moving in a circle. demonstrated that the decay behavior of the classical expression for the correlation function can be recovered from a strictly periodic quantum mechanical expression by taking the limit ℏ→0, after the appropriate transformation. The aim of this study is to present clearly and in detail how the position correlation function for a system of particles moving in a circle having a certain average energy and written in a form which shows the nature of the transformation. Next, we examine the use of Poisson addition to represent F(z), and how the correlation function becomes identical to the form given by classical statistical mechanics, which exhibits Gaussian decay. The results of this study indicate that the positional correlation function for a system of particles moving in a circle, and having a certain average energy, can be written in a form which shows the nature of the transformation. Then using the Poisson addition formula to represent F(z), the expression is rewritten to enable the limit ℏ→0 to be taken. It was finally found that the correlation function became identical to the form given by classical statistical mechanics, which exhibits a Gaussian decay.
Elevator pitch
Authors: Juan David Vélez Aristizábal
Published: November 2023

Prueba tarea
Measuring Working Memory in Aphasic Individuals with Electroencephalography and N-Back Tasks
Authors: Concatto Fernando , Freitas Maurício Pasetto de , Catecati Tiago , González-Dalmau Evelio , Ramirez Alejandro
Published: November 2023

Aphasia is a neurological condition that manifests itself through
deficiencies in linguistic functions, which are essential for social
interaction and activities of daily living. This deficiency is
associated with a loss of working memory capacity, which is responsible
for the temporary storage of information. This work sought to develop an
approach to aid professionals involved in aphasia treatment and
rehabilitation programs, aiming to improve the manner in which evidences
of rehabilitation are obtained. The methodology is based on an
electroencephalography device, which captures brain signals from
individuals while they execute a task that stimulates verbal working
memory. The signals are processed using an approach based on
event-related potentials, which are then used as input to a statistical
model trained with a scientifically validated measurement of working
memory. The results indicated that the error of the model was slightly
larger than expected, but diminished proportionally to the amount of
training samples. We conclude the study suggesting research paths to
reduce the error of the model and investigate the feasibility of this
approach in a clinical context.
Heterozygosity is low where rare colour variants in wild carnivores prevail.
Authors: Tensen Laura , Fischer Klaus
Published: November 2023

Coat colour and pattern are a distinguished feature in mammalian
carnivores, shaped by climatic cycles and habitat type. It can be
expressed in various ways, such as gradients, polymorphisms, and rare
colour variants. Although natural selection explains much of the
phenotypic variation found in the wild, genetic drift and heterozygote
deficiency, as prominent in small and fragmented populations, may also
affect phenotypic variability through the fixation of recessive alleles.
The aim of this study was to test whether rare colour variants in the
wild could relate to a deficiency of heterozygotes, resulting from
habitat fragmentation and small population size. We present an overview
of all rare colour variants in the order Carnivora, and compiled
demographic and genetic data of the populations where they did and did
not occur, to test for significant correlations. We also tested how
phylogeny and body weight influenced the presence of colour variants
with phylogenetic generalized linear mixed models (PGLMMs). We found 40
colour-variable species and 59 rare colour variants. In 17 variable
phenotypic populations for which genetic diversity was available, the
average AR was 4.18, HO = 0.59, and HE = 0.66, and FIS = 0.086. We found
that variable populations displayed a significant reduction in
heterozygosity and allelic richness compared to non-variable populations
across species. We also found a significant negative correlation between
population size and inbreeding coefficients. Therefore, it is possible
that small effective size had phenotypic consequences on the extant
populations. The high frequency of the rare colour variants (averaging
20%) also implies that genetic drift is locally overruling natural
selection in small effective populations. As such, rare colour variants
could be added to the list of phenotypic consequences of inbreeding in
the wild.
Correlation of inhaled long-acting bronchodilators with cardiovascular adverse events in COPD patients: A real-world analysis of post-marketing surveillance data
Authors: che erxi , Yi Li , Ding Ling-qing , Yan Zhiwen , Yang Jiayong
Published: November 2023

Background: The question of whether inhaled long-acting bronchodilators
(iLABs) increase the incidence of cardiovascular adverse events (CVAEs)
remains unresolved. The present study analyzed real world data using the
U.S. Food and Drug Administration Adverse Events Reporting System
(FAERS) database to evaluate iLABs-related CVAEs in patients with COPD.
Methods: Disproportionality analysis was used in data mining to screen
the suspected CVAEs after different iLABs based on the FAERS database
(0/12014-12/2022). The times to onset, outcomes of iLABs-associated
CVAEs were also investigated. Results: We identified 12152 reports of
adverse events related to three classes of drugs (LABAs, LAMAs, and
LABAs combined with LAMAs), of which 591(4.86%) were CVAEs specific to
cardiac failure, ischemic heart disease and cardiac arrhythmia. The
percentage of men who were affected was higher than that of women
(66.80% vs. 30.73%), and elderly patients were more vulnerable than
middle-aged patients (52.81% vs. 21.53%). Compared with the full
database, the use of iLABs was associated with a higher reporting rate
of major CVAEs (n=591, ROR=1.44, 95%CI, 1.30-1.60). LABAs may have a
stronger association, based on the highest ROR value (n=304, ROR=1.91,
95%CI, 1.67-2.18). The majority of cardiovascular events related to
iLABs occurred within the first 30 days after drug initiation.
iLABs-associated CVAEs generally led to mortality and hospitalization
rates of 46.19% and 62.61%, respectively. Conclusions: According to
the FAERS database, we profiled CVAEs related to various iLABs with more
details on occurrences, clinical characteristics, and prognosis.
Concerns should be placed on patients with new initiation of iLABs.
Predicted Dose-Response to Combination of Zibotentan with Fixed-Dose Dapagliflozin in the ZENITH Trial Population: A Mathematical Modeling Analysis
Authors: Yu Hongtao , Greasley Peter , Heerspink Hiddo Lambers , Ahlstrom Christine , Hamren Bengt , Ambery Philip , Khan Anis , Boulton David , Hallow Melissa
Published: November 2023

Background and Purpose: Selective endothelin A (ETA) antagonism has
shown promise as a potential treatment for chronic kidney disease (CKD),
but the adverse effect of fluid retention associated with ETA
antagonists has limited their clinical utility. Combination of low doses
of the selective ETA antagonist zibotentan with a fixed-dose
sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin is
currently being evaluated in the Zibotentan and Dapagliflozin for the
Treatment of CKD (ZENITH-CKD) clinical trial as an approach to maximize
kidney protection via ETA antagonism and SGLT2 inhibition in
combination. Approach: This study utilized a quantitative systems
pharmacology modeling approach to simulate the dose-response
relationship of zibotentan alone and in combination with dapagliflozin
in a virtual CKD patient population. Key Results: Simulations predict
that interstitial fluid volume (IFV) changes will remain below baseline
for zibotentan doses below 0.5 mg when combined with dapagliflozin,
while the combination therapy will provide substantial additional
improvements in urinary albumin-to-creatinine ratio (uACR), glomerular
hypertension, and proximal tubule energy demand, indicating enhanced
renoprotection. The simulation also indicate that patients with higher
baseline eGFR (>30 mL/min/1.73m2) and baseline uACR
(>800 mg/g) may experience greater kidney protective
response to the combination therapy with less potential for detrimental
fluid retention. Conclusions and impact: If the predicted results are
confirmed by the ZENITH-CKD trial, this analysis will enhance
mechanistic understanding of the balance between albuminuria reduction
and fluid retention with this combination treatment strategy, and will
provide a tool to inform optimal population selection for late phase
clinical studies and lifecycle management planning.
The emerging importance of cross-ploidy hybridisation and introgression
Authors: Brown Max , Abbott Richard J , Twyford Alex
Published: November 2023

Natural hybridisation is now recognised as pervasive in its occurrence
across the Tree of Life. Resurgent interest in natural hybridisation
fuelled by developments in genomics has led to an improved understanding
of the genetic factors that promote or prevent species cross-mating.
Despite this body of work overturning many widely held assumptions about
the genetic barriers to hybridisation, it is still widely thought that
ploidy differences between species will be an absolute barrier to
hybridisation and introgression. Here, we revisit this assumption,
reviewing findings from surveys of polyploidy and natural hybrids in the
wild. In a case study in the British flora, 203 hybrids representing
35% of hybrids with suitable data have formed via cross-ploidy matings,
while a wider literature search revealed 48 studies (45 in plants and 3
in animals), where cross-ploidy hybridisation has been confirmed with
genetic data. These results show cross-ploidy hybridisation is readily
overlooked, and potentially common in some groups. General findings from
these studies include strong directionality of hybridisation, with
introgression usually towards the higher ploidy parent, and cross-ploidy
hybridisation being more likely to involve allopolyploids than
autopolyploids. Evidence for adaptive introgression across a ploidy
barrier and cases of cross-ploidy hybrid speciation show the potential
for important evolutionary outcomes.
Dynamika wartości aktywów na polskim rynku funduszy inwestycyjnych
Authors: Satoła Łukasz
Published: November 2023

W artykule podjęto problematykę zmiany wartości aktywów zarządzanych przez towarzystwa funduszy inwestycyjnych. Analiza dotyczy okresu zmiennej koniunktury na rynkach kapitałowych. Na tym tle przedstawiono dynamikę wartości aktywów netto w poszczególnych grupach funduszy. Wskazano również na czynniki, które oddziaływały na decyzje inwestorów odnośnie wyboru określonych rodzajów funduszy. Badania dowiodły, że największy udział w wartości aktywów mają fundusze akcji oraz mieszane, natomiast najszybciej rozwijającą się grupą są fundusze nieruchomości i sekurytyzacyjne. Maleje znaczenie funduszy ochrony kapitału oraz stabilnego wzrostu.
Polityka opodatkowania nieruchomości w gminach województwa małopolskiego w latach 2007-2010
Authors: Satoła Łukasz
Published: November 2023

Polityka podatkowa gmin należy do najistotniejszych działań w zakresie pozyskiwania dochodów własnych umożliwiających finansowanie ustawowych zadań samorządu. W dobie kryzysu znaczenie właściwie prowadzonej polityki podatkowej wzrasta z uwagi na ograniczone możliwości kreowania innych źródeł dochodu. Celem artykułu jest ocena zróżnicowania polityki podatkowej gmin w zakresie stosowanych przez nie stawek podatku od nieruchomości. Wyniki badań wskazują na duże zróżnicowanie stosowanych przez gminy stawek podatku od nieruchomości. Nie widać natomiast istotnych różnic w prowadzonej polityce podatkowej w okresie dynamicznego wzrostu gospodarczego i kryzysu ekonomicznego.
Photocoagulation for retinal hemangioblastoma in Von Hippel-Lindau disease
Authors: Vasilijevic Jelena , Pantelic Jelica , Mirkovic Jelena , Al Barri , Kovacevic Igor
Published: November 2023

Introduction. Von Hippel?Lindau disease is a hereditary, autosomal dominant, tumor syndrome with a predisposition to developing various benign and malignant tumors. Retinal hemangioblastoma is often the presenting manifestation. We report a case of Von-Hippel?Lindau disease in a 13-year-old girl with bilateral eye involvement. Case outline. The patient was referred to the Eye Clinic, University Clinical Center of Serbia, with a diagnosis of Coats disease. Clinical examination revealed that best corrected visual acuity was 20/20 on her right eye, while her left eye showed counting fingers at 20 cm distance. Dilated fundoscopy of the right eye revealed multiple tortuous feeding vessels leading to orange-reddish, sharply demarcated multiple lesions on the far periphery of the upper retina, corresponding to retinal hemangioblastoma. the left eye showed edematous optic nerve head, tortuous retinal vessels, exudates, and retinal detachment including macula. Considering that the patient had multiple bilateral retinal hemangioblastomas and that her father had pathohistologically proven brain hemangioblastoma and numerous visceral tumors, Von Hippel?Lindau disease was assumed. Focal argon laser photocoagulation was performed in the region of all visible vascular tumors and feeding vessels in the right eye. The patient?s visual acuity remained unchanged five months after the disease detection. Conclusion. The importance of education about dominant inheritance pattern of Von Hippel?Lindau disease cannot be overemphasized. Role of an ophthalmologist is critical in early diagnosis of both retinal hemangioblastoma and Von Hippel?Lindau disease.
A dedicated amputee sports programme improves physical functioning and sports participation
Authors: Van Oorschot Wieneke , Keijsers Noël , Van Ee Ir. René F.
Published: November 2023

Objective: People with a lower-limb amputation often have a sedentary lifestyle and increasing physical activity is important to optimize their health and quality of life. To achieve this the Amputee Parateam programme was developed. Amputee Parateam is a sports programme that addresses important physical, environmental, and social barriers for sports participation. This programme was evaluated in terms of various aspects of physical functioning and health.
Design: Repeated measures design.
Patients: Thirteen participants with a lower-limb amputation, with a median age of 51 (interquartile range (IQR) 40–63).
Methods: Measurements were performed at T0 (baseline), T1 (after 6 weeks) and T2 (follow-up after 12 months). Outcome measures were walking ability, functional mobility, daily activity, health-related quality of life, and adherence to sports at follow-up.
Results: Walking ability and functional ability significantly improved between T0 and T1. Adherence to sports at follow-up was high, with 11/13 participants still practicing sports weekly. There were no significant changes in daily activity or health-related quality of life.
Conclusions: The Amputee Parateam programme successfully improved walking ability and functional mobility and resulted in a high adherence to sports among the participants. However, these improvements in physical capacity did not lead to less sedentary behaviour in daily life.
Study Protocol: Text Performers—Using Speech-to-Text Technology to Support Students With Dyslexia During Text Production
Authors: Mossige Margunn , Bundgaard Svendsen Helle , Almgren Bäck Gunilla , Svensson Idor , Dolmer Grete , Fälth Linda , Berg Gøttsche Nina , Rønneberg Vibeke , Selenius Heidi
Published: November 2023

This protocol article describes the background, theoretical framework, and methods for two intervention studies using assistive technology to produce text. The participants will be 15 10–12-year-old students with dyslexia from Denmark, Norway, and Sweden. The first study aims to examine how an intervention focusing on using speech-to-text technology influences texts written by students with dyslexia, and the second study aims to investigate the writing process when students with dyslexia use speech-to-text technology. Study 1 uses a multiple baseline design, whereas Study 2 uses verbal protocols.
Organic Mulching Effects on Water Productivity, Soil Temperature, Growth and Yield of Lentil Varieties
Authors: Shirisha Karupakula , Ray Lala I. P. , Parida Pradosh Kumar , Singh A. K. , Singh N. J.
Published: November 2023

The experiment was conducted at College of Post Graduate Studies in Agricultural Sciences, Umiam, Meghalaya during the rabi season (November–April, 2022) to study the effect of organic mulching on growth, yield and water productivity of lentil varieties in mid-hills of Meghalaya. The experiment was carried out in split plot design with four mulch treatment under main plot (M0: un-mulch/control, M1: paddy straw mulch, M2: maize stover mulch, M3: weed mulch) and four varietal treatments under sub plot (V1: HUL-57, V2: PL-4, V3: PDL-1 and V4: PSL-9) which were replicated thrice. Results indicated that, plant height, number of branches plant-1, water productivity were highest under paddy straw mulch. Paddy straw mulch (43.57) which was on par with weed mulch (41.29) has reported significantly highest number of pods plant-1 over maize stover mulch (38.18) and un-mulch (36.21) treatments. Different mulches have reported economic yield advantage of 21.01% to 10.55% over the control. Water productivity has found significantly higher under paddy straw mulch (3.25 kg ha-1 mm-1) over the control treatment (2.57 kg ha-1 mm-1). Mulches also modified soil thermal regimes and effected plant growth and development. Soil temperature has shown increasing trend towards the end of crop season, since, air temperatures are increasing towards the end of growing season. Paddy straw mulch, weed mulch and maize stover mulch increased 2.31oC, 1.88oC, 0.27oC temperature, respectively, over the control during morning hours.
Effect of Growth Regulators on Growth and Quality of Strawberry cv. Sweet Sensation Grown in Pot Culture
Authors: Panda D. , Mondal S.
Published: November 2023

A pot culture experiment was conducted at Institute of Agriculture, Visva-Bharati, Sriniketan, West Bengal, India during the rabi season (October, 2018–March, 2019) to study the effect of growth regulators such as 28-Homobrassinolide and Triacontanol on growth and yield of strawberry cv. Sweet Sensation. The treatments consisted of seven levels of growth regulators including control viz. control, 0.5 ppm, 1 ppm and 2 ppm of 28-Homobrassinolide and 2ppm, 5 ppm and 10 ppm of Triacontanol. The effect of growth regulators was studied on different morpho-physiological parameters and biochemical and quality parameters such as chlorophyll content of leaves, ascorbic acid, titratable acidity and TSS of fruit. The results revealed that the foliar application of 0.5 ppm of 28-Homobrassinolide produced the maximum plant height, number of leaves plant-1, petiole length, canopy spread, leaf area plant-1, crown diameter, shoot dry weight and root dry weight, RWC, number of flowers plant-1, number of fruits plant-1, percent fruit set, fruit length and fruit diameter, chlorophyll content of leaves, whereas the treatment of 1 ppm of 28-Homobrassinolide recorded maximum plant height, petiole length. However, the minimum value of the morphological, biochemical, yield and quality parameters were recorded in control (foliar spray of water). Hence form present study it may be confirmed that foliar application of 28-Homobrassinolide @ 0.5 ppm and 1 ppm significantly improved the growth, yield, and quality attributes of strawberry.
Optimization of Ready-to-Cook Chicken Cutlet Mix Using Different Levels of Antioxidant Dietary Fiber Enriched Dehydrated Vegetable Mix
Authors: Tomar Serlene , Chauhan Geeta , Das Annada , Meshram Somesh
Published: November 2023

A study was conducted during a period of six (6) months from June to December, 2019 at the Division of Livestock Products Technology, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India to develop a nutritious, convenience and shelf stable ready-to-cook chicken cutlet mix extended with dried vegetables as a source of antioxidant dietary fiber.  Dehydrated vegetable mix was added at three different levels (2.5, 5 and 7.5%) and compared with control having no added vegetables. The results revealed that the dehydrated vegetable mix proved to be an additional source of minerals and dietary fibre in the chicken cutlet mix. Extension of ready-to-cook cutlet mix improved the yield, and colour saturation of the mix. The chicken cutlets prepared using the extended mix offered improved juiciness and overall acceptability along with better textural profile.  Physico-chemical analysis revealed that the mix was shelf stable due to its low water activity and moisture content and hence could probably be stored for long periods of time. Extension of the mix with DVM enhanced the functionality of the product by improving its antioxidant potential.  However, as indicated by sensory evaluation higher levels of dehydrated vegetables (7.5%) altered the colour, texture and flavour of developed product.  Hence, 5% level of DVM was found to be the most suitable level for extension of the ready-to-cook mix. Therefore, extension with dehydrated vegetables could serve to meet technological and functional properties in the development of convenient, nutritious and tasty ready-to-cook dehydrated mix, which could serve an alternative to fresh meat cutlets.