bluuebunny/crossref_metadata_2025 huggingface dataset:
DETERMINANTS OF FORMATION OF TRUE RESISTANCE TO ANTIHYPERTENSIVE TREATMENT IN PATIENTS WITH ARTERIAL HYPERTENSION WITH CONCOMITANT OBESITY
Authors: Psarova Valentyna , Kochuieva Maryna , Kochuiev Gennadii , Tymchenko Tymchenko , Hrek Ivan , Kyrychenko Nataliia
Published: July 2021

The aim of the research: identify combinations of genetic and neurohumoral factors that influence the development of true resistance to antihypertensive therapy (AHT) in patients with concomitant obesity (OB).
The study included 200 patients aged 45–55 with uncontrolled hypertension and obesity. Treatment was prescribed in accordance with the European Guidelines 2018. Thiazide-like diuretics were additionally prescribed to those patients who did not reach the target blood pressure (BP) level after 3 months of dual therapy. Resistant hypertension was diagnosed in 48 patients who had an uncontrolled course of hypertension at the optimal doses of three antihypertensive drugs during the next month of their reception, while true resistance was found in 21 patients. The effectiveness of comprehensive treatment was evaluated after 6 months.
The application of the logistic regression method at the stage of initial examination of patients showed that the early predictors of the formation of truly resistant hypertension in obese patients are CIMT, HOMA index and genetic polymorphism IRS-1.
After treatment, the model of truly resistant hypertension in patients with obesity included indicators that influenced its formation at the pre-treatment stage, as well as the new ones: adiponectin, waist circumference and genetic polymorphism ADIPOQ.
Genetic markers, insulin resistance, and vascular wall status play a leading role in the development of true resistance to AHT in obese patients. It is established that the main determinants of the formation of true resistance to AHT in patients with this comorbidity are IRS-1 polymorphism, HOMA index and CIMT.
ENDOGENOUS INTOXICATION SYNDROME ACTIVITY IN BILIARY AUTONOMIC VISCERO-VISCERAL CARDIONEUROPATHY
Authors: Strilchuk Larysa M. , Kondratyuk Marta O.
Published: July 2021

Toxic excess of biologically active substances named middle molecules (MM), which include byproducts of normal and altered metabolism, products of inflammation and oxidation, bacterial remnants, antibodies and immunoactive substances, plays an important role in pathogenesis of gallbladder diseases and biliary autonomous viscero-visceral cardioneuropathy (BAVVCNP). In order to assess activity of the endogenous intoxication syndrome secondary to BAVVCNP, we examined 20 patients with coronary heart disease to determine the levels of MM in the blood (total and at 238, 254, 266, and 280 nm waves); the levels of MM in urine (at 238, 254, 266, 282, 288, and 310 nm waves) with calculation of aromaticity index (MM 238/280), peptide-nucleotide index (MM 238/266), distribution index (MM 280/254), and L-arginine, and nitrites of the urine. The results were statistically processed.
It was revealed that in case of BAVVCNP the severity of the endogenous intoxication syndrome was higher for all specific parameters of endotoxicosis, and especially for the total level of MM in blood (0.77 ± 0.13 units vs. 0.46 ± 0.13 units, p = 0.08), the MM level at 238 nm wave (1.53 ± 0.55 vs. 0.49 ± 0.06, p = 0.08) and hydrophilic MM level in the urine at 288 nm long waves (0.72 ± 0.12 vs. 0.40 ± 0.11, p = 0.05) and 310 nm (0.27 ± 0.08 vs. 0.10 ± 0.03, p <0.05). According to the literature, this may indicate an increase in levels of cholecystokinin, leptin, endothelin, proinflammatory interleukins and tumor necrosis factor α. According to the correlation analysis, activation of endogenous intoxication syndrome was associated with lipid distress syndrome, increased leptin content and accelerated renal filtration.
MATRIX METALLOPROTEINASES AS MARKERS OF RESPIRATORY TRACT REMODELING AND POTENTIAL THERAPEUTIC TARGET IN PATIENTS WITH BRONCHIAL ASTHMA
Authors: Kachkovska Vladyslava V.
Published: July 2021

It is evidently known that chronic inflammatory process in the bronchi of patients with bronchial asthma is associated with the emergence and progression of airway remodeling, resulting in irreversible obstruction. However, the exact mechanisms of connection between inflammation and airway remodeling are not very well understood and that is the reason for delay of development new specific targeted drugs aimed to inhibit the process of inflammation and remodeling. Therefore, our goal was aimed to analyze and systematize data on the role of matrix metalloproteinases in the occurrence of airway remodeling in patients with bronchial asthma and the possibility of therapeutic effects on this process.
Materials and methods: search for information on the role and mechanisms of influence of matrix metalloproteinases on airway remodeling processes in patients with bronchial asthma and the possibility of its pharmacological correction in electronic databases such as PubMed and Google Scholar over the past 25 years.
Matrix metalloproteinase-9 and tissue proteinase-1 inhibitor have been shown to play the most important role in airway remodeling in the presence of bronchial asthma, supported by numerous experimental and clinical studies. Much attention is paid to the comparison of these indicators in bronchoalveolar lavage, induced sputum and blood on the background of exacerbation and in the presence of a stable course of the disease. The analysis of their content depending on the severity of the course, dysfunction of external respiration and the degree of reversibility of bronchial obstruction. Studies of the possibility of drug effects on the content of remodeling markers have shown low clinical efficacy. The results are contradictory, but most of them prove the important role of matrix metalloproteinase-9, tissue protease inhibitor-1 and their relationship in the occurrence and progression of airway remodeling and, consequently, the severity of the disease, which dictates the need to develop new additional treatments.
PENGARUH JUMLAH KUNJUNGAN WISATAWAN, PENERIMAAN PAJAK HOTEL, PAJAK RESTORAN TERHADAP PAD KABUPATEN SIKKA
Authors: Rieshe Rieshe , Aji Andri Waskita
Published: July 2021

ABSTRACT The purpose of this research is to find out how much influence: (1) the number of tourist visits to the Sikka Regency's original income; (2) hotel tax revenue from the Sikka Regency's original regional income; and (3) restaurant tax receipts from Sikka Regency's original revenue to Sikka Regency's original revenue both partially and simultaneously at the Sikka Regional Financial Management and Asset Management Service (DPPKAD). The data analysis technique used in this study is multiple linear regression analysis. The F test, t test and R² test are processed using SPSS version 16.0. The results of data analysis with a significance of 0.05 indicate that the variable number of tourist visits and hotel tax revenue variables do not affect the original income of Sikka Regency 2016-2018. While the restaurant tax has a positive and significant effect on the original income of Sikka district 2016-2018. The results of the study simultaneously showed that the number of tourist visits, hotel tax receipts and restaurant tax receipts had a positive and significant effect on the genuine income of Sikka Regency. Independent and Dependent Variables affect 36% while 64% are explained independently by variables outside this research model.Keywords: tourist visits, hotel tax, and restaurant tax, first income of region ABSTRAK Tujuan penelitian ini adalah untuk mengetahui seberapa besar pengaruh: (1) jumlah kunjungan wisatawan terhadap pendapatan asli daerah Kabupaten Sikka; (2) penerimaan pajak hotel dari pendapatan asli daerah Kabupaten Sikka; dan (3) Penerimaan Pajak Restoran dari Pendapatan Asli Daerah Kabupaten Sikka terhadap Pendapatan Asli Daerah Kabupaten Sikka baik secara parsial maupun simultan di Dinas Pengelolaan Keuangan dan Aset Daerah (DPPKAD) Sikka. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis regresi linier berganda. Uji F, uji t dan uji R² diolah dengan menggunakan SPSS versi 16.0. Hasil analisis data dengan signifikansi 0,05 menunjukkan bahwa variabel jumlah kunjungan wisatawan dan variabel penerimaan pajak hotel tidak berpengaruh terhadap pendapatan asli daerah Kabupaten Sikka tahun 2016-2018. Sedangkan, pajak restoran berpengaruh positif dan signifikan terhadap pendapatan asli daerah kabupaten Sikka tahun 2016-2018. Hasil penelitian secara simultan menunjukkan bahwa jumlah kunjungan wisatawan, penerimaan pajak hotel dan penerimaan pajak restoran berpengaruh positif dan signifikan terhadap pendapatan asli Kabupaten Sikka. Variabel independen dan dependen mempengaruhi 36% sedangkan 64% dijelaskan secara independen oleh variabel di luar model penelitian ini.Kata kunci: kunjungan wisatawan, pajak hotel, dan pajak restoran, pendapatan pertama daerah
A NEAT quantum error decoder
Authors: Théveniaut Hugo , van Nieuwenburg Everard
Published: July 2021

We investigate the use of the evolutionary NEAT algorithm for the optimization of a policy network that performs quantum error decoding on the toric code, with bitflip and depolarizing noise, one qubit at a time.
We find that these NEAT-optimized network decoders have similar performance to previously reported machine-learning based decoders, but use roughly three to four orders of magnitude fewer parameters to do so.
Confronting the Past Abuses: Indonesia and Southeast Asia
Authors: Sulistiyanto Priyambudi
Published: July 2021

This article examines the politics of reconciliation in Indonesia and Southeast Asia. It focuses in particular on the case of Talangsari killings in Indonesia and makes a regional comparison with Thailand, Cambodia, the Philippines and Myanmar. The Indonesian experience illustrates some of the complex issues that arise when attempts are made to dealing with past abuses, especially in the context of the constraints and possibilities faced by new democracies. In a comparative perspective what is being experienced in Indonesia is not new in the sense that, as argued by scholars elsewhere, new democracies also have to face this kind of situation.1 This article argues that dealing with the past human rights abuses brings about real power struggles among the contending actors and power holders and it reflects the power structures within and outside the country. It is suggested that there is no “universal” model for dealing with past human rights abuses but some form of accountability which brings together the elements of prosecution, reconciliation and forgiveness could be considered.
Effect of magnetic iron-zirconium modified zeolite on the different phosphorus forms in river sediment under aerobic and anoxic conditions
Authors: Wang Chunlei , Gui Herong , Li Chen , Chen Jiayu , Chen Chen
Published: July 2021

In this study, a magnetic iron-zirconium modified zeolite (FeZrMZ) was synthesized. Through sediment culture experiments, the influence of the addition of modified materials on the migration and transformation of phosphorus in river sediments was investigated. The results showed that the modified zeolite could not only effectively reduce the phosphorus concentration in the overlying water, but also significantly reduce the phosphorus concentration in the pore water of sediments. The addition of modified zeolite makes the unstable weakly adsorbed phosphorus (NH4Cl-P) and redox phosphorus (BD-P) transform into the more stable metal oxide-bound phosphorus (NaOH-P) and very stable residual phosphorus (Res-P). The four types of bioavailable phosphorus (BAP), including water-soluble phosphorus (WSP), readily desorbable phosphorus (RDP), algae-available phosphorus (AAP), and NaHCO3 extractable phosphorus (Olsen-P). Under anoxic conditions, they were reduced by 53.5%, 14.1%, 23.8%, and 49.9% respectively. Under aerobic conditions, they were reduced by 23.2%, 16.6%, 32.1%, and 50.0%. The addition of magnetic iron-zirconium modified zeolite could clearly reduce the release potential of phosphorus in sediment, and it could be recovered through the action of an external magnetic field, so it could be used as an effective sediment modifier to control the sediment release of phosphorus.
Application of free software FreeFem++/Gmsh and FreeCAD/CalculiX for simulation of static elasticity problems
Authors: Nasibullayev I.Sh.
Published: July 2021

The paper discusses the stages of computer numerical simulation of engineering problems and ways to improve the accuracy of simulation; provides a brief overview of free software for simulation elasticity problems by the finite element method, as well as trends in the development of free CAD and CAE software. For a successful engineering study, it is necessary to choose a convenient tool that takes into account all the features of the problem being solved. Based on the solution of a test static problem of linear elasticity, two approaches to engineering modeling were demonstrated. The first approach requires programming skills - the full modeling cycle was written in the programming language of the FreeFem++ software. Additionally, the method mesh generating in the Gmsh program with subsequent use in the FreeFem++ program is shown. In the second approach, the full cycle of modeling is carried out through the interface of the FreeCAD program with the built-in CalculiX solver, which does not require programming skills. A way to parameterize the task using the Python interpreter built into FreeCAD is also proposed. The simulation results obtained using both approaches are compared for an object to which an external action is applied, determined by the Dirichlet or Neumann boundary conditions, and two types of object fastening are analyzed: rigid embedding and limitation by a plane with zero friction. The analysis of the use of computing resources by various direct and iterative methods is carried out. Within the framework of the considered test problem of static linear elasticity, the most optimal method in FreeFem++ is the iterative method of conjugate gradients CG both in terms of computation time and in terms of the memory used. The highest speed of calculations is provided by the Cholesky iterative method with conditioning by the incomplete Cholesky expansion in the CalculiX program.
Transformations of gas dynamics equations and basis operators of a admitted 11-dimensional Lie algebra
Authors: Siraeva D.T. , Yulmukhametova Y.V.
Published: July 2021

In this paper, the gas dynamics equations are considered. The system is closed by a general equation of state. This equations describe a model of an inviscid non-heat-conducting gas motion in the absence of external force fields and external energy sources. The system is invariant under the 11-parameter group with the corresponding 11-dimensional Lie algebra. The gas dynamics equations, equations of motion, and basis operators of the Lie algebra are written in Cartesian, Cylindrical, and Spherical coordinate systems. The steps involved when changing the coordinate system are illustrated in detail.
Jumping drops on the surface of the water
Authors: Terentiev A.G.
Published: July 2021

The paper proposes a theoretical model for the bouncing of a water drop on a free surface. The motion of a drop in air is described by the usual equations connecting the forces of inertia, gravity, and Stokes (viscosity resistance). The drop is considered spherical with a given surface tension. Numerical calculations were carried out using the same algorithm, but with different initial conditions. Some conditions are set for the droplet disintegration, others for the droplet reflection from the free surface. It is shown that the disintegration of a drop occurs periodically with a decrease in the drop size and an increase in the drop rise height. In the interval between droplet decays, periodic reflection from the free surface occurs with a decrease in the rise height.
Evaluación de la ansiedad en gestantes en tiempos del Covid-19, Hospital Luis Negreiros Vega, Callao-2020
Authors: Vara Tarazona Lourdes Amparo , Rimari Miranda Fanny
Published: July 2021

Objetivos: Determinar la evaluación de la ansiedad en gestantes en tiempos del COVID-19, hospital Luis Negreiros Vega, Callao- 2020. Materiales y métodos: El enfoque metodológico de este estudio fue de diseño descriptivo-transversal. La población estuvo conformada por 350 gestantes que fueron atendidas en el área de ginecología y obstetricia. La técnica utilizada fue la encuesta y el instrumento de medición fue State Trait Anxiety Inventory (STAI), el cual está constituido por 40 ítems y dos subescalas las cuales son mencionadas como ansiedad de estado (AE) y ansiedad de rasgo (AR). Resultados: En cuanto a los participantes, la edad mínima fue 14 años y máxima 42 años, siendo la edad media 30,95 años. En relación al nivel de la ansiedad, predomino el nivel moderado con 76,3% (n=267), seguido del nivel leve en un 14,3% (n=50) y alto con 9,4% (n=33). En cuanto a la ansiedad de estado, predomino el nivel moderado con 78,6% (n=275), seguido del nivel leve en un 16,9% (n=59) y alto con 4,6% (n=16). En relación a la ansiedad de rasgo, predomino el nivel moderado con 66% (n=231), seguido del nivel alto en un 20% (n=70) y leve con 14% (n=49). Conclusiones: De acuerdo a la ansiedad en gestantes, predomino el nivel moderado, seguido del nivel leve y alto. En cuanto a las dimensiones, en todas predomino el nivel moderado.
Conocimientos y actitudes hacia la donación voluntaria de sangre en estudiantes de una universidad pública de Lima-Perú
Authors: Cuba Sancho Juana Matilde , Paredes García Verónica Amparo , Merino Lozano Alicia Lourdes
Published: July 2021

Objetivo: Determinar los conocimientos y actitudes hacia la donación voluntaria de sangre que tienen los estudiantes de Enfermería y Medicina de una universidad pública, 2018. Material y Métodos: investigación aplicada, con enfoque cuantitativo, descriptivo-comparativo, transversal. La muestra estuvo conformada por 59 estudiantes de Enfermería y 64 estudiantes de Medicina.  Se empleó como técnica la encuesta y como instrumentos un cuestionario para conocimientos y una escala tipo Likert modificada para actitudes, previo consentimiento informado. Resultados: El 86% de los estudiantes de Enfermería y el 88% de Medicina tienen conocimientos acerca de la donación voluntaria de sangre; el 63% de estudiantes de Enfermería y el 59% de medicina no conocen los requisitos para donar sangre como la edad, el peso, intervalo de donación, entre otros; el 70-69% de estudiantes de ambas facultades conoce el procedimiento que se realiza como la cantidad de sangre que se debe donar, contraindicaciones, la importancia, lugares de donación; referente a la actitud que presentan hacia la donación de sangre el 65% de estudiantes de medicina y el 56% de enfermería manifiestan una actitud de aceptación mientras que el 27% y 42% de estudiantes de medicina y enfermería mostraron una actitud de indiferencia constituyéndose en un nudo crítico, que debe ser abordado por los profesionales de la salud diseñando estrategias que permitan generar una cultura de la donación en la población en general. Conclusiones: La mayoría de los estudiantes de enfermería y medicina tienen conocimientos sobre la donación de sangre y el procedimiento que se aplica, sin embargo, la mayoría desconoce los requisitos que se necesita para donar; respecto a la actitud la mayoría de los estudiantes muestran aceptación, y otro grupo minoritario indiferencia.
Análisis del Gasto del Bolsillo en el Servicio Dental de los Afiliados al SIS de Lima Metropolitana según Enaho, 2018
Authors: Diaz-Mujica Juana Yris , Panduro Tello Maycol Alan orlando
Published: July 2021

Objetivos: Estimar gasto de bolsillo en el servicio dental de los afiliados al SIS de Lima Metropolitana según Enaho 2018. Materiales y métodos: Estudio cuantitativo, descriptivo, de diseño no experimental, transversal y retrospectivo. La técnica fue la recolección de datos mediante la ficha de registro tomando datos secundarios de la “Encuesta Nacional de Hogares sobre Condiciones de Vivienda y Pobreza, Enaho, 2018”, la muestra fue de 14,874 personas que han sido atendidas en el servicio dental en el año 2018. Resultados: A intervalos de 9,705059 y 19,95492 como limites inferior y superior a una desviación estándar de 2,610325 el gasto de bolsilo fue de 14,82999; en relación al gasto por sexo en promedio, el de la mujer fue de 19,46143 y del varon  9,914876; el gasto segun edad indica que el grupo de 65 a 69 años gasta en promedio 40,03425 soles; el gasto por nivel educativo indica que los que tienen nivel inicial gastan 40,24546; y en cuanto a nivel de pobreza, los pobres extremos presentan gastos de 0,000 mientras que el pobre no extremo 2,850577. Conclusiones: Se concluyo que el gasto del bolsillo de afiliados al SIS por servicios dentales es de 14,80 soles en promedio, en Lima Metropolitana
Fatores possíveis de promover ou comprometer a motivação de estudantes de ciências contábeis: análise em uma instituição de ensino de Minas Gerais
Authors: Da Silva Costa Breno , Gonçalves de Faria Janaina , Camargos Avelino Bruna , Vianna Brugni Talles
Published: July 2021

Objetivo: O objetivo desta pesquisa é avaliar os fatores que influenciam a motivação de estudantes do curso de Ciências Contábeis de uma Instituição de Ensino Superior localizada em Minas Gerais, à luz da Teoria da Autodeterminação.

Metodologia: Para avaliar a motivação dos discentes, 70 estudantes do primeiro ano do curso de Ciências Contábeis e 100 alunos matriculados no 8º, 9° e 10° períodos da graduação em análise, ou seja, na fase final do curso, compuseram a amostra deste estudo mediante o preenchimento de um questionário contendo a versão brasileira da Escala de Motivação Acadêmica (EMA), composta por 29 questões.

Resultados: Foi possível inferir, por meio das médias encontradas para os fatores, que os discentes da fase inicial do curso estão mais autodeterminados e intrinsecamente motivados do que desmotivados com o percurso acadêmico. Em relação à motivação dos respondentes do final da graduação, se comparada à motivação de indivíduos matriculados na fase inicial do curso, constatou-se que a maioria deles encontra-se mais desmotivado no final da graduação.

Contribuições do Estudo: Tendo em vista os resultados encontrados, cabe à coordenação do curso, juntamente com os professores, refletirem quanto à adequação curricular, visando atender os anseios dos estudantes. Da mesma forma, compete aos professores o aperfeiçoamento da didática e metodologia de ensino, com vistas a suprir as necessidades dos discentes, assim como propiciar um ambiente favorável ao aprendizado. Acredita-se que essas são algumas medidas que irão contribuir para aumentar o nível de motivação dos alunos do curso de Ciências Contábeis e, consequentemente, melhorar o grau de satisfação destes indivíduos com relação à graduação oferecida pela IES em análise
Sentimentos de culpa vivenciados na pós-graduação
Authors: Biernaski Kachenski Ricardo , da Silva Sousa Rayane Camila , Zepeda Toro Pavel Elias , Costa Flaviano , Colauto Romualdo Douglas
Published: July 2021

Objetivo: A pesquisa consiste em verificar o nível de concordância dos estudantes quanto aos sentimentos de culpa vivenciados na pós-graduação stricto sensu.

Metodologia: O estudo é de caráter descritivo com abordagem quantitativa. A coleta dos dados foi realizada por meio de survey e o instrumento de coleta de dados foi a Escala Multidimensional da Culpabilidade de Aquino e Medeiros (2009). Para análise dos dados utiliza-se Análise Fatorial Exploratória e o teste Kruskal-Wallis (KW) para verificar as diferenças entre os grupos.

Resultados: Os resultados evidenciaram que há diferenças de distribuição do sentimento Culpa Temporal, Culpa Subjetiva e Culpa Objetiva. A maioria dos respondentes concordou totalmente com os sentimentos de culpa descritos no Fator Culpa Temporal. A pós-graduação stricto sensu tem uma alta demanda de estudos, pesquisas e atividades extras que ocupam boa parte do tempo dos estudantes, assim o aspecto temporal acaba sendo uma de suas principais preocupações, desencadeando o sentimento de culpa.

Contribuições do Estudo: O estudo ajuda a compreender se os estudantes se sentem culpados por diversas situações corriqueiras na vida das pessoas e, futuramente, pode-se analisar se o nível de sentimento de culpa interfere no desempenho acadêmico; se desenvolve atitudes tóxicas no relacionamento interpessoal entre outros fatores comportamentais.
Formação didático-pedagógica dos egressos da pós-graduação stricto sensu em ciências contábeis de uma instituição federal de ensino superior
Authors: Fernandes Thayná de Oliveira , Dos Santos Araújo Valdineide , Nóbrega Cavalcanti Paulo Roberto
Published: July 2021

Objetivo: O presente estudo objetivou investigar a formação didático-pedagógica no curso de pós-graduação em Ciências Contábeis de uma Instituição Federal de Ensino Superior.

Metodologia: Buscou-se os alunos egressos da pós-graduação (stricto sensu) atual na Instituição Federal de Ensino Superior (IES) em estudo e do Programa Multiinstitucional e Inter-Regional de Pós- Graduação em Ciências Contábeis que permaneceu antes da criação do atual programa de pós-graduação da IES, chegando ao número de 65 (Sessenta e cinco) egressos até março de 2018, dos quais 42 (quarenta e dois) retornaram o questionário respondido. Quanto aos objetivos, trata-se de uma pesquisa descritiva e quanto à abordagem do problema, tem caráter qualitativo. Ademais, no plano metodológico, a opção pela abordagem foi a pesquisa documental e de campo.

Resultados: Os resultados foram analisados através da análise de conteúdo conforme Bardin (2011) e estatística descritiva. Estes apresentam-se quanto ao perfil dos egressos, sua reflexão da atuação como docente, tendo sido observado uma lacuna em competências de metodologia de ensino e didático-pedagógicas na formação dos egressos. Quanto à análise documental, verificou-se que as disciplinas que objetivam assuntos de formação didático-pedagógica são tratadas como eletivas. Além disso, os egressos percebem que houve uma formação acadêmica de excelência, com um bom aprofundamento de conhecimentos específicos das diversas áreas não exploradas na graduação e com contribuição na construção de conhecimento na área de estudo. Ante esse cenário, a formação é contínua, sendo necessária durante toda a prática docente, pois o aprender é constante e essencial nessa profissão.

Contribuições do Estudo: A pesquisa contribui para analisar a formação acadêmica recebida pelos egressos da Pós-graduação stricto sensu em Ciências Contábeis e para refletir sobre a formação docente recebida pelos dos sujeitos da pesquisa.
The effect of the introduction of market makers on stock liquidity: evidence from the Brazilian stock market
Authors: Carvalho Gabriel Augusto de , Ribeiro João Eduardo , Correia Laíse Ferraz
Published: July 2021

Purpose: This study aimed to analyze whether the introduction of market makers as specialized intermediaries in the trading of stocks listed on the Brazilian stock exchange is a useful procedure for increasing the market liquidity of these assets.

Methodology: The Chow structural break test was performed in the time series of the liquidity proxies, average spread, turnover ratio, and financial volume on a sample of 55 stocks. We chose to consider data in the window of 260 days before and after the start of the market maker's activity, because it represents the approximate number of trading sessions in a year, and to avoid erroneous conclusions due to the volatility of the Brazilian stock market.

Results: The results showed with a 99% confidence level that after the introduction of market makers, (i) 67% of the stocks analyzed had abrupt and statistically significant changes in the average spread; (ii) 47% in the turnover ratio; and (iii) 60% had changes in the volume transactions. At the confidence level of 95%, (i) 76% of the stocks analyzed showed abrupt changes in the average spread; (ii) 65% had changes in turnover; (iii) and 69% had changes in the trading volume. Using a lower confidence level of 90%, the results revealed 85% of the stocks had abrupt and statistically significant changes in the average spread, 78% in the turnover ratio, and 73% in the trading volume.

Contributions of the Study: This paper provides strong evidence on the performance of market makers and the influence they have on the market liquidity of stocks traded on the Brazilian stock exchange. We found that contracting market makers increase market liquidity and contribute significantly to the assets’ transactions.
Salpingopharyngeus fistula by means of videosurgery to treat horse bilateral gutural pouch chronic empyema – a case study
Authors: Strugava Lucimara , Lorga Andressa Duarte , Gomes Anny Raissa Carolini , Rossa Ana Paula , Janiszewski Jéssica do Rocio , Dornbusch Peterson Triches
Published: July 2021

The aim of this paper is to report the Salpingopharyngeus fistula technique by means of videosurgery through a natural orifice (NOTES) in order to treat bilateral empyema. A mare was seen at the Large Animal Sector of UFPR, with a history of bilateral purulent nasal discharge associated with dysphagia lasting for ninety days. The animal was submitted to endoscopy, showing a moderate amount of purulent secretion in both guttural pouches. With no improvement on the clinical treatment, we opted for surgical treatment by endoscopy through Salpingopharyngeus fistula made with the aid of a device containing an electrical scalpel developed to perform this technique. It consisted of making an incision in the pharyngeal recess in order to access the guttural pouches and subsequently drain the purulent content. The patient was discharged at the same day and returned to work 30 days after the procedure. Surgical treatment for cases of guttural pouch empyema is indicated when the clinical resolution has not been effective, and the minimally invasive technique is indicated due to the reduction of risks and the easiness of postoperative management. Until this moment, there are no reports of the salpingopharyngeal fistula technique through video surgery for the treatment of guttural pouch empyema, which has proved to be efficient for the treatment of the disease.
Ultrasound and excretory urography findings in the diagnostic of congenital renal ectopy of a dog
Authors: Santos Letícia Maria de Almeida , Trindade Taysa , Bordignon Luiza , Kaiser Ana Letícia , Lunedo Jaqueline , Jojima Flávio Shigueru
Published: July 2021

Renal ectopy is a rare condition in small animals, characterized by abnormal positioning of one or both kidneys. It is classified as simple or crossed and, according to its localization, being diagnosed in an incidental way in pets because of its nonspecific and many times asymptomatic clinical presentation. Imaging exams such as ultrasound, radiography, and excretory urography may close the diagnosis. This paper reports a case of simple, unilateral, renal ectopy, in a three-year-old male Lhasa Apso dog, with no clinical or laboratory findings consistent with renal disease, in which the ectopic condition, together with shape, rotation, and vascular abnormalities, were incidental findings during abdominal ultrasound examination.
Antiprotozoal and Anthelmintic Activity of Zinc Oxide Nanoparticles
Authors: do Carmo Neto José Rodrigues , Guerra Rhanoica Oliveira , Machado Juliana Reis , Silva Anielle Christine Almeida , da Silva Marcos Vinicius
Published: July 2021

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Nanomaterials represent a wide alternative for the treatment of several diseases that
affect both human and animal health. The use of these materials consists, mainly, in trying to
solve the problem of resistance that pathogenic organisms acquire to conventional drugs. A
well-studied example that represents a potential component for biomedical applications is the
use of zinc oxide (ZnO) nanoparticles (NPs). Its antimicrobial function is related, especially to
the ability to generate/induce ROS that affects the homeostasis of the pathogen in question.
Protozoa and helminths that harm human health and the economic performance of animals
have already been exposed to this type of nanoparticle. Thus, through this review, our goal is
to discuss the state-of-the-art effect of ZnONPs on these parasites.
The Screening of Phytochemicals Against NS5 Polymerase to Treat Zika
Virus Infection: Integrated Computational Based Approach
Authors: Rehman Abdur , Ashfaq Usman Ali , Javed Muhammad Rizwan , Shahid Farah , Noor Fatima , Aslam Sidra
Published: July 2021

Background:

The recent Zika Virus (ZIKV) outbreak provides a spur for new, efficient,
and safe anti-Zika Virus agents. RNA-dependent RNA polymerase (RdRp) is critical amongst the
seven non-structural proteins for viral replication and considered an attractive drug target.

Methods:

In this study, molecular docking approach was used to rationally screen the library of
5000 phytochemicals to find inhibitors against NS5 RdRp. LigX tool was used to analyze the 2D
plots of receptor-ligand interactions. The top-ranked compounds were then subjected to in-silico
pharmacokinetic study.

Results:

The compounds namely Polydatin, Dihydrogenistin, Liquiritin, Rhapontin and Cichoriin
were successfully bound inside the pocket of NS5 RdRp. Polydatin was the leading phytochemical
that showed high docking score -18.71 (kcal/mol) and bonding interaction at the active-site of NS5
RdRp. They were subjected to analyze drug-like properties that further reinforced their validation
and showed that they have more capability to attach with the receptor as compared to
SOFOSBUVIR control drug. MD simulation of the top two complexes was performed and the
simulated complexes showed stability and ligands were kept within the bonding pocket.

Conclusion:

The study might facilitate the development of a natural and cost-effective drug
against ZIKV. Further validation, however, is necessary to confirm its effectiveness and its
biocompatibility.
Biocatalytic Synthesis of Terpene Esters and their Biological Activity in
Human Glioma Cells
Authors: Kutyła Mateusz , Maciejczyk Aleksandra , Trytek Mariusz , Jakubowicz-Gil Joanna
Published: July 2021

Background:

Gliomas are highly malignant brain tumours with high resistance to
chemotherapy. Therefore, investigations of new therapeutic molecules with high anti-glioma activity
are of great importance.

Objective:

In this work, biocatalytic esterification of terpene alcohols with proven anti-cancer activity
was performed to enhance their potency to induce cell death in human glioblastoma multiforme
T98G and anaplastic astrocytoma MOGGCCM cell lines in vitro.

Method and Results:

We used primary terpene alcohols and carboxylic acids with a length of
two to nine carbon atoms. The structure of the alcohols had an influence on the esterification efficiency,
which decreased in the following order: monocyclic > linear > bicyclic. Terpene alcohols
and their esters only induced apoptotic cell death, which is highly desirable from a therapeutic
point of view, but did not induce autophagy and necrosis. The esterification of perillyl alcohol
with butyric acid caused a 4-fold increase in cell death induction in the T98G line. Citronellol valerate,
caprylate, and pelargonate and myrtenol butyrate, caprylate and pelargonate also showed
higher activity than their alcohol precursors.

Conclusion:

We have herein shown that esterification of natural alcohols by biocatalysis can be used
for improving the activity of other compounds investigated for their anti-glioma activity.
Recent Patent-Based Perspective on Diagnostic and Therapeutic Interventions in Malignant Mesothelioma: Is Drug Repositioning Knocking on the Door?
Authors: Yadav Vikas , Safari Roghaiyeh
Published: July 2021

Background:

Malignant Mesothelioma (MM), an orphan but aggressive malignancy of
the mesothelial membrane, is a fatal tumour. Global epidemic related to malignant pleural mesothelioma
is on the rise, so there is a need to explore novel biomarkers and ingenious therapeutic approaches
to stalk this silent killer.

Objective:

The main aim of the present review is to provide a consolidated overview of the recent active patents related to diagnosis and therapy in MM that will affect its future management.

Methods:

A search of existing literature was conducted from a PubMed database search. Recent patent
information was fetched out from online free open-access databases. For related clinical trials,
www.clinicaltrial.gov was searched.

Results:

Patent search data showed 72 active patents related to diagnosis and therapy in the field of
MM, which we classified into eight broad categories. Of these, maximum 17 patents were attributed
to immunotherapy and 13 were attributed to “Drug Repositioning” and “Biological / synthetic”
based candidates. Relatively low number of patents accounts for gene signature (7), epigenetics (3)
and microRNA (2) based diagnosis and therapy. Remaining 17 patents were distributed amongst virotherapy
and various miscellaneous categories. Furthermore, our clinical trial based investigation
revealed the futuristic impact of listed patents in MM patient management.

Conclusion:

This review article has provided an overview of patent based advancement in the field
of MM, which might become apex in the clinical settings in future. Interestingly, immunotherapy
and “drug repositioning” based therapy seems to be the front-runners in the race to provide relief.
escolha de uma carreira no ensino em Portugal: Motivos e autoeficácia de estudantes de mestrado
Authors: Barros Sílvia , Peixoto Carla , Pessanha Manuela , Ferreira Tiago , Barros Ana , Kiel Ewald , Weiß Sabine , Keller-Schneider Manuela
Published: July 2021

Neste estudo analisaram-se os motivos de estudantes para escolherem a carreira docente e respetivas associações com variáveis ​​sociodemográficas, com características do curso de formação de professores e com crenças de autoeficácia. Participaram 183 estudantes (86% mulheres) de cursos de mestrado em ensino de instituições portuguesas, que preencheram um questionário on-line sobre características sociodemográficas, motivos da sua decisão de se tornarem professores (Kiel, Geider, & Junger, 2004) e crenças de autoeficácia (Schwarzer & Jerusalem, 1995; versão portuguesa de Araújo & Moura, 2011). Através da análise fatorial, foram derivados quatro fatores subjacentes aos motivos para ser professor: (a) Benefícios da profissão, (b) Influências sociais, (c) Interesse no curso ou nos conteúdos académicos, e (d) Promoção do desenvolvimento das crianças/adolescentes. Foram encontrados valores médios mais elevados nos motivos relacionados com a Promoção do desenvolvimento das crianças/adolescentes e com o Interesse no curso/nos conteúdos académicos. Foram encontradas diferenças estatisticamente significativas entre os motivos de estudantes que optaram por um curso que profissionaliza para a educação pré-escolar e/ou primeiro ciclo e os que optaram por um curso que profissionaliza para o ensino de disciplinas específicas, assim como em função da idade, do género e da autoeficácia. As implicações para a formação de professores são discutidas.
Ambiente percebido na formação inicial: investigação com estudantes universitários de educação física
Authors: Backes Ana Flávia , Lima Ahlan Benezar , Oliveira Vinícius Plentz , Arantes Luciane Cristina , Salles William das Neves , Moura Willian Alexander Marcheti , Nascimento Juarez Vieira
Published: July 2021

O objetivo do estudo foi investigar o ambiente de formação inicial percebido por estudantes universitários de Educação Física. Participaram 273 estudantes universitários (Bacharelado n=150; Licenciatura n=123) de uma universidade pública de Santa Catarina (Brasil). Aplicou-se a versão adaptada do Questionário de Avaliação do Ambiente Percebido da Formação Inicial em Educação Física. Realizou-se regressão logística binária para verificar a associação entre as variáveis. Os resultados revelaram que os licenciandos perceberam maior ocorrência de discussões em grupo (OR=2,07), seminários teóricos (OR=1,72), aprendizagem pela prática e desenvolvimento de atitudes reflexivas (OR=1,70) do que os bacharelandos. O ambiente de formação inicial percebido foi similar entre os cursos, mas os licenciandos perceberam mais oportunidades de participação e reflexão.
Influencing factors in elementary school teachers by proposing homework to students in the Región of Murcia (Spain)
Authors: Cascales-Martínez Antonia , Pamies-Berenguer Marcial , Carrillo-García María Encarnación
Published: July 2021

El objetivo de este artículo es definir los factores que influyen en los maestros de primaria al proponer tareas a los estudiantes. El estudio se realizó con una muestra de 93 docentes en servicio activo en la Región de Murcia (España), que respondieron un cuestionario validado, a través de un juicio experto por el método Angoff (Ricker, 2006), que consistió en 35 preguntas. El análisis de datos relacionados con los factores definidos, tales como: participación familiar, sentimientos personales, decisiones y suposiciones del personal; Tener en cuenta las variables definidas como: frecuencia de tareas, actividades por semana y tareas necesarias, nos ayuda a concluir que existen factores decisivos para el profesorado cuando propone tareas al alumnado y estos factores están condicionados por el número de días por semana que el profesorado propone tareas al alumnado, el número estimado de actividades por semana asignadas al alumnado y el tiempo necesario para completar la tarea.
Precisión y eficiencia del inventario de plantaciones de teca en Ecuador mediante escáner láser terrestre
Authors: Peñalver Romeo Alberto , Aguilar Torres Fernando J. , Nemmaoui Abderrahim , Rivas Barzola José Ricardo , Triana Tomalá Ángel Antonio , Aguilar Torres Manuel A. , Llanderal Alfonso
Published: July 2021

El objetivo de la investigación fue evaluar la precisión y eficiencia del método de inventario forestal usando el escáner láser terrestre para la determinación de variables dendrométricas en plantaciones de teca (Tectona grandis Linn. F.). Se establecieron sitios de muestreo circulares de 500 m2 en plantaciones de teca de tres predios de la región Costa de Ecuador donde se usaron las metodologías de inventario forestal tradicional y del escáner láser terrestre, registrando las variables dendrométricas (diámetro normal, altura total y radio de copa) y el tiempo de trabajo necesario para complementar el inventario de cada parcela. Las estimaciones de los índices dasométricos para cada método de inventario y la eficiencia relativa del método del escáner láser terrestre con respecto al inventario forestal tradicional fueron contrastadas mediante pruebas de inferencia estadística. La prueba de contrastes estadísticos aplicada no detectó diferencias significativas entre los dos métodos de inventario en relación tanto con las variables dasométricas medidas como con los tiempos de trabajo registrados en cada parcela. Los valores de eficiencia relativa evidenciaron cierta superioridad del inventario realizado con el escáner láser terrestre sobre el realizado con el inventario forestal tradicional. El presente estudio permite concluir que el método del escáner láser terrestre para la elaboración de inventarios forestales en plantaciones de teca es preciso para la estimación de variables dasométricas, siendo más eficiente que el de inventario tradicional.
Влияние облучения ионами аргона на фильтрационные свойства многостенных углеродных нанотрубок
Authors: Elsehly E.M. , Евсеев А.П. , Воробьева Е.А. , Балакшин Ю.В. , Чеченин Н.Г. , Шемухин А.А.
Published: July 2021

The wettability and filtration efficiency of multi-walled carbon nanotubes (MWCNT) under irradiation with Ar+ ions with an energy of 100 keV have been investigated. Energy dispersive X-ray spectroscopy, Raman spectroscopy, and scanning electron microscopy were used to study the residual manganese content in the filter, as well as to study the structure of irradiated MWCNTs. High fluence irradiated MWCNT (HR-MWCNT) filters showed an improvement in Mn removal of up to 99.6% at a Mn concentration of 10 ppm. HR-MWCNT based filters are extremely hydrophilic, with a 66° wetting angle and high absorption capacity. The efficiency of manganese removal from an aqueous medium has been studied as a function of pH, initial concentration, and mass of MWCNT.
Исследование диодов Шоттки на основе массива кремниевых волокон, полученных сухим криогенным травлением
Authors: Баранов А.И. , Кудряшов Д.А. , Уваров А.В. , Морозов И.А. , Шугуров К.Ю. , Максимова А.А. , Вячеславова Е.А. , Гудовских А.С.
Published: July 2021

We consider arrays of vertically aligned nanowires obtained by dry cryogenic etching of silicon wafers with n = 1016 cm-3 and 1017 cm-3, 6 µm in height and 1.7 µm and 1.2 µm in diameter, respectively. It has been demonstrated that the deposition of gold forms a Schottky diode with an ideality coefficient of 1.1-1.3 and a barrier height of 0.6-0.7 eV to these arrays. It is shown that the experimental curves of the capacitance-voltage characteristics of such structures can be analyzed using a model that takes into account the contribution to the capacitance from all surfaces of the nanowires. This made possible to numerically estimate the concentration profile of free charge carriers in the array of nanowires, which showed good numerical agreement with the doping level in the initial wafers.
Увеличение эффективности трехпереходных солнечных элементов за счет метаморфного InGaAs-субэлемента
Authors: Минтаиров М.А. , Евстропов В.В. , Минтаиров С.А. , Нахимович М.В. , Салий Р.А. , Шварц М.З. , Калюжный Н.А.
Published: July 2021

The efficiency of GaInP/GaAs/InxGa1-xAs triple-junction solar cells obtained by replacing (in the widely used "classical" GaInP / GaAs / Ge heterostructure) the lower germanium with InxGa1-xAs subcell formed using the metamorphic growth technology has been investigated. Based on an original approach, the optimal indium concentration in the narrow-gap subcell has been found. The main parameters of InxGa1-xAs subcells with an indium concentration from x = 0.11 to 0.36 were determined and were used to calculate the IV characteristics of GaInP/GaAs/InxGa1-xAs solar cells. It has been determined that at x=0.28 the efficiency of the triple-junction solar cell increases by 3.4% (abs) in comparison with the “classical” solar cell, reaching a value of 40.3% (AM1.5D). Also it has been shown that the efficiency of such solar cells can be increased up to 41%.