bluuebunny/crossref_metadata_2025 huggingface dataset:
The Glasgow prognostic score predicts survival in patients with advanced non-small cell lung cancer harboring sensitive EGFR mutations who are treated with tyrosine kinase inhibitors
Authors: Akazawa Yuki , Igawa Satoshi , Yamada Kaori , Yamamoto Hiroki , Yagami Yuri , Kaizuka Nobuki , Manaka Hiroya , Kasajima Masashi , Nakahara Yoshiro , Sato Takashi , Mitsufuji Hisashi , Yokoba Masanori , Kubota Masaru , Sasaki Jiichiro , Naoki Katsuhiko
Published: November 2022

Background: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) with sensitive EGFR mutations. The Glasgow prognostic score (GPS) is an inflammation-assessing score based on C-reactive protein and albumin concentrations. Information regarding the association between the GPS and EGFR-TKI treatment effectiveness is limited; hence, we investigated whether the GPS can predict the response of NSCLC to EGFR-TKIs.
Methods: We evaluated 340 patients with NSCLC harboring sensitive EGFRmutations who received EGFR-TKI monotherapy between March 2009 and July 2021. The Kaplan–Meier method and Cox proportional hazards models were used to assess progression-free survival (PFS) and overall survival (OS).
Results: After a median follow-up of 26.6 months, patients with a GPS of 0, 1, and 2 had PFS of 15.7, 10.0, and 6.3 months, respectively, and OS of 40.1, 25.8, and 14.4 months, respectively; patients with a GPS of 0 had significantly better PFS and OS than those with a GPS of 1 (P=0.03, P=0.001, respectively) or 2 (P<0.001, P<0.001, respectively). Multivariate analysis identified poor performance status, stage IV at diagnosis, type of EGFR-TKI (gefitinib/erlotinib vs. afatinib), and GPS=2 as predictors of a short PFS. Meanwhile, poor performance status, gefitinib/erlotinib administration, and GPS=2 were predictive of a short OS.
Conclusions: The GPS predicted the survival of NSCLC patients harboring sensitive EGFRmutations who were undergoing EGFR-TKI treatment. The GPS might be ideal for routine use in clinical practice, given that it is an easily calculated parameter.
Efficient removal of safranin from aqueous solution using a new type of metalated highly self-doped polyaniline nanocomposite
Authors: Hassan Hammed H. A. M. , Fattah Marwa Abdel
Published: November 2022

We report the chemical synthesis of poly(aniline-co-aniline-2,5-disulfonic acid)) in a composite containing L-hexuronic acid and metallic Ag/SiO2 nanoparticles as a new anionic polyelectrolyte for removing safranin dye. The composite was characterized by IR, UV, cyclic voltammetry, SEM, TEM, TGA, DSC, EDXS and elemental analyses. Microscopic images of the metallic nanospheres exhibited well-separated spherical particles, while the targeted nanocomposite displayed intensified spherical particles that were dispersed over almost the entire surface. The XRD exhibited peaks of amorphous silica and crystalline silver at many 2q values, and their interatomic spacing values (d) and crystallite (grain) sizes were calculated. The thermal degradation curves exhibited interesting models of stability of copolymers and their weight losses left more than 50% as a residue. The cyclic voltammograms exhibited characteristic redox peaks relative to the quinoid ring transition states. Experimental parameters such as pH, adsorbent dose, contact time, and dye concentration were studied to evaluate the efficiency of copolymers as safranin adsorbents. The uptake rates up to 82.5% adsorption were completed within 75 min and the equilibrium time was 45 min. The adsorption maximum removal values were 73.6% and 59.3% at pH 9, while the maximum removal percentages were 55% and 68.3% attributed to overcrowding of adsorbent molecules that prohibit dye/adsorbent binding. From the Langmuir and Freundlich isotherm models used to interpret the dye/adsorbent interaction, the former isotherm was the optimum to represent the dye uptake. Different kinetic models to study adsorbent capacity through chemisorption and physisorption were also investigated.
Blastocystis in raw vegetables from street markets in northern Thailand
Authors: Jinatham Vasana , Wandee Thanawat , Nonebudsri Chadsiri , Popluechai Siam , Tsaousis Anastasios D. , Gentekaki Eleni
Published: November 2022

Blastocystis is a stramenopile protist of controversial pathogenicity. The organism colonizes a broad range of vertebrate and invertebrate hosts. Blastocystis has also been found in the environment both in water and soil. Several routes of transmission have been proposed including human-to-human, animal-to-human and via contaminated food and water. In recent years, the presence of Blastocystis in vegetables has started to be explored. However, most studies have focused on microscopic detection. Moreover, works of this type from Asia are barely available. Hence, the aim of this preliminary study was to examine the occurrence of Blastocystis in raw vegetables sold in markets in northern Thailand. Fresh produce (n=20) commonly used in Thai cuisine (Lanna) was purchased from two street markets and screened for Blastocystisusing qPCR. Blastocystis was detected in 45% of the samples with the dominant subtype being ST3. Produce growing underground, such as galangal, carrot and beetroot were positive for the organism suggesting soil or inadequately composted manure as the source of contamination. To our knowledge, our study is the first to perform subtyping of Blastocystis in vegetables. Our results hint towards fresh produce being an, as yet, not widely explored, transmission route of Blastocystis in the studied community. Looking forward, large-scale investigations should on the prevalence of this and other organisms under the One Health umbrella should be undertaken.
Intraoperative pleth variability index-based fluid management therapy and gastrointestinal surgical outcomes in elderly patients: A randomised controlled trial
Authors: Wang Yu , Zhang Yue , Zheng Jin , Dong Xue , Wu Caineng , Guo Zhijia , Wu Xinhai
Published: November 2022

BACKGROUND
Intraoperative goal-directed fluid therapy (GDFT) has been reported to reduce postoperative complications of patients undergoing major abdominal surgery. The clinical benefits of pleth variability index (PVI)-directed fluid management for gastrointestinal (GI) surgical patients remain unclear. Therefore, this study aimed to evaluate the impact of PVI-directed GDFT on GI surgical outcomes in elderly patients.
METHODS
This randomised controlled trial was conducted in two university teaching hospitals from November 2017 to December 2020. In total, 220 older adults undergoing GI surgery were randomised to the GDFT or conventional fluid therapy (CFT) group (n = 110 each). The primary outcome was a composite of complications within 30 postoperative days. The secondary outcomes were cardiopulmonary complications, time to first flatus, postoperative nausea and vomiting, and postoperative length of stay.
RESULTS
The total volumes of fluid administered were less in the GDFT group than in the CFT group (2.075 L versus [vs.] 2.5 L, P = 0.008). In intention-to-treat analysis, there was no difference in overall complications between the CFT group (41.3%) and GDFT group (43.0%) (odds ratio [OR] = 0.935; 95% confidence interval [CI], 0.541–1.615; P = 0.809). The proportion of cardiopulmonary complications was higher in the CFT group than in the GDFT group (19.2% vs. 8.4%; OR = 2.593, 95% CI, 1.120–5.999; P = 0.022). No other differences were identified between the two groups.
CONCLUSIONS
Among elderly patients undergoing GI surgery, intraoperative GDFT based on the simple and non-invasive PVI did not reduce the occurrence of composite postoperative complications but was associated with a lower cardiopulmonary complication rate than usual fluid management.
Trial Registration:
This trial was registered with the Chinese Clinical Trial Registry (ChiCTR-TRC-17012220) on 1 August 2017.
Chemical composition and effect of essential oils of Thymus vulgaris and Origanum vulgare on adults and ovigerous masses of Pseudosuccinea columella
Authors: Ito Mitsue , Sperandio Natânia do Carmo , Silva Ygor Henrique da , Boeloni Jankerle Neves , Ignacchiti Mariana Drummond Costa , Avelar Barbara Rauta , Queiroz Vagner Tebaldi , Costa Adilson Vidal , Martins Isabella Vilhena Freire
Published: November 2022

Fasciolosis is a worldwide distribution zoonosis that causes great damage in ruminant breeding and has the aquatic mollusk Pseudosuccinea columella as an intermediate host. Synthetic molluscicides are the most used for control; however, they are harmful to fauna and flora. Therefore, this study aimed to evaluate the effect of essential oils from Thymus vulgaris, Origanum vulgare, and terpenecarvacrol, on adult mollusks and eggs of P. columella. Analysis of EO volatile components was carried out on a gas chromatograph equipment coupled with mass spectrometry selective detector. The studied components were diluted in concentrations of 10, 20, 40, 60, 80 and 100 ppm, and it was observed that O. vulgare at concentrations of 60, 80 and 100 ppm, carvacrol at the concentrations of 80 and 100 ppm, and T. vulgaris at a concentration of 80 ppm led to 100% mortality of mollusks. All concentrations the substances tested showed 100% ovicidal activity.
Econometric Analyses of Linear and Nonlinear Price Convergence of Products in 72 Indian cities and its Impact on national Economy
Authors: Ka Khnd Md Mostafa
Published: November 2022

In exploring the inflation dynamics in India, the study employs different econometric techniques of price convergence test. Using a panel data of 72 cities covering the period of January 2003 to December 2016 across 17 product categories, the study finds that prices do tend to converge to the law of one price (LOP) in India. The study also estimates the half- lives for price convergence and finds a reasonable speed of convergence varying from two to twenty months with a median estimate of nine months. Moreover, the study divulges that transportation cost and rail networks throughout India appear to be significant determinants of price dispersion. The Exponential Smooth Transition Autoregressive (ESTAR) model reveals that 86% of the Indian city exhibit price convergence towards one price either in linear or nonlinear fashion. In summary, this empirical study provides strong evidence in favour of the view that regional markets have been increasingly integrating in India over time. JEL: C10, C50, E31, E60
Numerical investigation of a novel bidirectional composite vibratory finishing
Authors: Yang Yingbo , Li Wenhui , Wang Xiuzhi , Hao Yupeng , Yang Shengqiang , Li Xiuhong
Published: November 2022

Given the poor accessibility of the current finishing process for parts with complicated geometries, a novel bidirectional composite vibratory finishing (BCVF) approach is presented, which combines the power actions on abrasive particles and processed workpieces. The discrete element method (DEM) was used to obtain a fundamental understanding of the BCVF process. By comparing different processes, it has been demonstrated that the BCVF promotes the mobility of abrasive particles to improve the finishing results and efficiency further. The characteristics of normal and tangential contact on the surface of the workpiece involved in the BCVF process were analyzed. Meanwhile, the effects of container size (or wall effects), media amount, workpiece position, and vibration parameters (including vibration amplitude and frequency) on the media-component interactions were systematically studied. The results show that the distance between the workpiece and the container wall in the y-direction can be reduced to 4d (d is the abrasive particle diameter) without affecting the finishing effect. In addition, with the enhancing vibration in the x-direction, particle impact and shear effects are subsequently strengthened. In contrast, the media amount above the workpiece and the z-directional vibration is mainly effective for the shear effect. Overall, the process can enhance the impact and shear effects simultaneously through composite vibration.
Cobalt-doped double-layer α-Fe2O3 nanorod arraysfor enhanced photoelectrochemical reduction of Cr(Ⅵ)
Authors: Bai Long , Wang Jueyu , Cui Daizong , Zhao Min
Published: November 2022

Element doping is one of the most important methods for improving the performance of photoelectrochemical (PEC) cells. It can change the electronic structure of the catalyst and the separation of the photogenerated charges and increase the carrier density, and thus energy density of the electrode materials. In this study, a Co-doped α-Fe2O3 double-layer electrode was prepared using a two-step hydrothermal method. Scanning electron microscope (SEM) showed that double-layer nanostructures were successfully deposited on a fluorine-doped tin oxide (FTO) substrate using this approach. X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) showed that the doping did not materially change the morphology of the nanostructures, while diffuse reflectance spectrum (UV-vis DRS) showed that there were only slight changes to the flat bandgap. Electrochemical tests showed that doping greatly improved the current density irrespective of whether the cobalt was doped in the upper or the lower layer. The best performing configuration was that of the FTO/α-Fe2O3:Co/α-Fe2O3 electrode, which achieved a current density of 1.37 mA/cm2. The Co-doped double-layer α-Fe2O3 nanorod arrays proved to possess a high photoelectric synergistic ability for the reduction of Cr (VI) in an aqueous solution, with 84.85% reduction in 180 min. Under the influence of the electric field inside the double-layer electrode, the photoexcited electrons and holes are transferred to the surface of the FTO substrate and the photoanode, increasing the current density. This study offers an alternative approach for designing novel photoanodes with improved PEC performance by engineering the electron density distribution and band structure for efficient carrier separation.
Dynamic detection of water in a working face floor using cross-inclined borehole Electrical Resistivity Tomography (ERT)
Authors: Gao Weifu , Wu Pengzheng , Wang Lidong , Wang Kewei
Published: November 2022

A dynamic detection system was established by cross-inclined borehole electrical resistivity tomography (ERT), in order to monitor the water flow in Ordivician limestone (0LS) during development process of working face. The following approaches were adopted by the detection system. First, two inclined boreholes were constructed in the transportation roadway, and the metal joints of the cables were coupled to the surrounding rock of the boreholes by attaching the cables to metal sheets and grouting. Second, with a self-designed cable protection device, the cables were led out of the borehole to prevent the cables from being damaged by high-pressure grouting. Finally, supporting trenches were established in the transportation tunnel to prevent the cables from breaking down due to the falling of rock from the roof. During the development process of working face, data were acquired in five times. Combined with the distribution of the mine pressure and hydrogeological conditions, the abnormal areas with a low resistivity were accurately interpreted from the detection results, providing an early warning for the water inrush events from the floor.
Exploring potential soybean bradyrhizobia from high trehalose-accumulating soybean genotypes for improved symbiotic effectiveness in soybean
Authors: Bharti Abhishek , Maheshwari Hemant S. , Garg Shivani , Anwar Khalid , Pareek Ashwani , Satpute Gyanesh , Prakash Anil , Sharma Mahaveer P.
Published: November 2022

Drought is the most important factor limiting the activity of rhizobia during N-fixation and plant growth. In the present study, we isolated Bradyrhizobium spp. from root nodules of higher trehalose accumulating soybean genotypes and examined for moisture stress tolerance on a gradient of polyethylene glycol (PEG 6000) amended in yeast extract mannitol (YEM) broth. In addition, the bradyrhizobial strains were also evaluated for symbiotic effectiveness on soybean. Based on 16S rDNA gene sequences, four bradyrhizobial species were recovered from high trehalose accumulating genotypes, i.e., two Bradyrhizobium liaoningense strains (accession number KX230053, KX230054) from EC 538828, PK-472 respectively, one Bradyrhizobium daqingense (accession number KX230052) from PK-472, and one Bradyrhizobium kavangense (accession number MN197775) from Valder genotype having low trehalose. These strains, along with two native strains viz., (Bradyrhizobium japonicum (JF 792425), Bradyrhizobium liaoningense (JF 792426), and one commercial rhizobium, were studied for nodulation, leghaemoglobin, and N-fixation abilities on soybean under sterilized sand microcosms conditions in a completely randomized design. Among all the strains, D-4A (B. daqingense) followed by D-4B (B. liaoningense) were found to have significantly higher nodulation traits, acetylene reduction assay (ARA), when compared to other strains and commercial rhizobia. The bradyrhizobia isolated showed plant-growth promotion traits such as Indole acetic acid (IAA) production, exopolysaccharide production (EPS), phosphate solubilizing potential, siderophore, and proline. The novel species B. daqingense was reported for the first time from Indian soil and observed to be a potential candidate strain and should be evaluated for conferring drought tolerance in soybean under simulated stress conditions.
Studies on Re-188 labeling and in vivo distribution of magnetic nanoparticles with different morphologies and sizes
Authors: Huang Xiaocui , Zhao Bo , Yang Yuxiang , Yuan Hongming , Yao Pingping , Carlini Riccardo , Huang Yan
Published: November 2022

There has been few research on the affect and distribution of different shapes of nanoparticles inside an organism during extraction and drug targeting. In order to obtain the distribution of magnetic nanoparticles with different morphology and size in vivo, a general method of Re-188 labeled Magnetic Core-Shell Nanoparticles (MNPs) Materials was developed. Based on the prepared magnetic particles with three different morphologies and sizes, including 230 nm spherical Fe3O4@SiO2 particles (S-230), 100 nm spherical Fe3O4@SiO2 particles (S-100) and peanut shaped Fe3O4@SiO2 particles (P-180,the length of the short axis is about 100 nm and the length of the long axis is about 180 nm),the aminated MNPs were labeled with radionuclide Re-188 through the coupling of diethylenetriamine pentaacetic anhydride (DTPAA). The nuclide Re-188 was labeled to investigate their distribution behavior in mice. Most of the small-size particles S-100 can be separated from the capture of the endothelial reticular system and removed by renal metabolism. Most of the larger particles, S-230 and P-180, will be captured by the endothelial reticular system, and the nanoparticles P-180 with large aspect ratio are easier to be captured by the tissue in the spleen and enter the cells through endocytosis.
Cost and Efficiency Analysis in Iranian Primary Health Centers: A Micro Costing and Data Envelopment Analysis
Authors: Mahboub-Ahari Alireza , Khanlari Somayeh , Yusefzadeh Hasan , Ghorbani Alireza
Published: November 2022

Background: As the first experience in Public-Private Partnerships, the Health Complex Model was implemented to provide primary health care services in urban, especially in slum areas. As a pilot at a provincial level, Chamran Health Complex offers healthcare for more than 57000 residents of Tabriz, the capital city of East Azerbaijan province. Despite the necessity of cost information in healthcare decision-making, there was limited knowledge about the unit cost of services. This study aims to analyze the cost and efficiency of Health Centers affiliated with Chamran Health Complex.
Methods: Activity-Based Costing method with direct and step-down allocation methods was adopted. Service throughput was gathered from the Iranian Integrated Health Record Portal and cost information from organization accounting records. We estimated unit costs in a hypothetical scenario according to national standards to quantify the gap between current and standard practice. Input-oriented Data Envelopment Analysis was administered to measure the efficiency of health centers.
Results:The total cost of the complex was $2841897, of which 67% ($1910373) and 33% ($931523) were accounted for direct and indirect costs, respectively. Among 80 service types, the vaccination center had the lowest ($9), and the occupational health center had the highest average unit cost ($76). The average technical efficiency of the health centers was 0.519, where the HC1 and HC3 showed the best performance compared to their counterparts.
Conclusions: There is remarkable variability in service costs across health centers, which must be addressed in performance management and contracting practices. Although we found a gap between current and standard practice in terms of staff and facilities according to national standards, Chamran Health Complex has an untouched capacity that can be utilized with better planning and without incurring additional costs. It raises the need for revising national standards by the Iran Ministry of Health.
Workload Analysis and Prediction of Multi-type GPU in Heterogeneous GPU Clusters
Authors: Wang Sheng , Chen Shiping , Shi Yumei
Published: November 2022

Heterogeneous GPU clusters play an important role in processing parallel applications and massive data sets in the cloud platform. However, due to the diversity of GPU types, how to effectively allocate various GPU types is a challenge. This paper first analyzes the characteristics of request and allocation for various GPU types based on Alibaba cluster data. Then we propose a method to adaptively select the best model to predict demand of various GPU types, and feature extraction from the best model. Further, we design a model based on Long Short Term Memory (LSTM) to forecast allocation of each GPU type. Finally, the extensive experimental results demonstrate the promising performance compared with multiple baseline methods by using real-world trace data from Alibaba cloud data centers. The trial illustrates that the demand prediction accuracy of the adaptive selection method reaches 87%, while the proposed prediction allocation model yields better performances with root mean square error and mean absolute error of 1.78 and 0.85, respectively.
LuGre or not LuGre
Authors: Rill Georg , Schaeffer Thomas , Schuderer Matthias
Published: November 2022

The LuGre model is widely used in the analysis and control of systems with friction. Recently, it has even been made available in the commercial multibody dynamics simulation software system Adams. However, the LuGre model exhibits well-known drawbacks like, too low and force rate dependent break-away forces, drift problems during sticking periods, and significant differences in non-stationary situations between the pre-defined friction law and the one produced by the LuGre model. In the present literature, these problems are supposed to come from the model dynamics or its nonlinear nature. However, most of these drawbacks are not simple side effects of a dynamic friction model but are caused in the LuGre approach, as shown here, by a too simple and inconsistent model of the bristle dynamics. Standard examples and a more practical application demonstrate, that the LuGre model is not a “what you see is what you get” approach. A dynamic friction model with accurate bristle dynamics and consistent friction force is set up here. It provides insight into the physical basis of the LuGre model dynamics. However, it results in a nonlinear and implicit differential equation, whose solution will not be easy because of the ambiguity of the friction characteristics. The standard workaround, a static model based on a simple regularized characteristics, produces reliable and generally satisfactory results, but definitely cannot maintain stick. The paper presents a second order dynamic friction model, which may serve as an alternative. It can maintain stick and produces realistic and reliable results.
Les droits de visite en détention et la santé mentale
Authors: Trajkovska Monika , Schmid Evelyne
Published: November 2022

Les personnes privées de liberté et affectées par des troubles de santé mentale sont singulièrement vulnérables. Selon de nombreuses études, les visites par les proches sont d'une importance particulière pour ces personnes. Dans cette contribution, nous évaluons les exigences de la Convention européenne des droits de l'homme (CEDH) sous l'angle de ces études empiriques quand les autorités sont amenées à déterminer la fréquence, la durée et les conditions des visites des proches d'une personne détenue et atteinte par un trouble de santé mentale. En pratique, deux phénomènes peuvent rendre difficile l'exercice de ces visites : D'une part, les autorités des centres de détention limitent les droits de visite p.ex. pour des raisons de sécurité. Dans d'autres cas, une personne privée de liberté exprime un souhait de ne pas recevoir des visites, mais ce souhait peut être influencé par un trouble mental qui affecte la communication ou parfois même la capacité de discernement. Nous examinons la jurisprudence de la Cour européenne des droits de l'homme (CourEDH) à la lumière de la littérature empirique pour suggérer des considérations dont doivent tenir compte les acteurs et actrices clés.

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Zahlreiche empirische Studien aus der Medizin, der Psychologie und der Kriminalistik betonen die Verletzlichkeit psychisch kranker Personen im Freiheitsentzug und die Bedeutung von Besuchen durch ihre Angehörigen. In der Praxis können zwei Phänomene die Durchführung solcher Besuche erschweren: Zum einen schränken die Behörden der Haftanstalten das Besuchsrecht z.B. aus Sicherheitsgründen ein. In anderen Fällen äussert eine Person im Freiheitsentzug manchmal den Wunsch, keine Besuche zu empfangen. Dieser Wunsch kann durch eine psychische Störung beeinflusst werden, welche die Kommunikations- und allenfalls die Urteilsfähigkeit der Person beeinträchtigt. In diesem Beitrag werden die rechtlichen Auswirkungen empirischer Studien in diesen beiden Arten von Situationen bewertet. Wir untersuchen die Rechtsprechung des Europäischen Gerichtshofs für Menschenrechte im Lichte dieser empirischen Literatur und schlagen Überlegungen vor, welche die wichtigsten Akteure bei der Festlegung der Häufigkeit, Dauer und Bedingungen von Besuchen berücksichtigen sollten.
Diagnóstico de Ateroma de Carótidas por Meio de Radiografia Panorâmica: Série de Casos
Authors: Silva Gabriel Araujo da , Diniz Maria Eduarda Santos , Almeida Híttalo Carlos Rodrigues de , Sobral Ana Paula Veras , Da Silveira Márcia Maria Fonseca
Published: November 2022

Na rotina odontológica, a radiografia panorâmica é utilizada com objetivo de observar a dentição e diagnosticar patologias maxilares. O ateroma caracteriza-se por uma calcificação na parede interna arterial sendo observada radiograficamente por uma massa radiopaca localizada no espaço intervertebral entre as vértebras C3 e C4. O presente estudo teve como objetivo relatar uma série de casos de diagnósticos por meio da radiografia panorâmica. Foram utilizados 4 casos de pacientes com imagens sugestivas de ateroma na radiografia panorâmica e com idade de 69 a 75 anos. No presente estudo, foi observado que a ocorrência bilateral foi mais frequente que a unilateral e maior incidência em pacientes acima dos 60 anos. Conclui-se que o exame radiográfico panorâmico estabelece uma relevante contribuição ao cirurgião-dentista no diagnóstico precoce e que o ateroma é um grande fator de risco para o acidente vascular cerebral.
Viscossuplementação com Ácido Hialurônico para o Tratamento de Rizartrose
Authors: Leite Ítalo Aurélio Fernandes , Gonçalves Vitor Araújo , Nocera Tiago Spessotto Bittar , Moreno Pedro Francisco de Mattos , Rezende Luis Guilherme Rosifini Alves , Shimaoka Filipe Jun , Mazzer Nilton
Published: November 2022

A rizartrose é uma afecção comum na prática diária do ortopedista e cirurgião de mão. É uma afecção comum em mulheres de meia-idade pós-menopausa. O tratamento conservador é a primeira linha terapêutica e o tratamento cirúrgico é indicado na sua falha. Contudo, alguns pacientes não desejam procedimentos cirúrgicos, sendo uma alternativa a infiltração com ácido hialurônico. O objetivo deste estudo é avaliar o resultado do tratamento com infiltração de ácido hialurônico em pacientes com rizartrose. Métodos: 38 pacientes submetidos ao tratamento com infiltração de ácido hialurônico para rizartrose foram avaliados retrospectivamente, tendo suas variáveis analisadas. Resultados: Houve melhora com diferença estatística para Pinça (Polpa: p=0,001; Lateral: p=0,001 e Tripode p=0,001), Força de preensão (média p=0,002), EVA (p=0,001), quick-DASH (p=0,01) e abdução palmar (p=0,001). O PRWE apresentou tendência de melhora (p=0,067). Conclusão: o tratamento com infiltração de ácido hialurônico é seguro em pacientes na falha do tratamento conservador que não desejam tratamento cirúrgico.
Learning through teaching: Teaching the nature of scientific inquiry in online outdoor learning environments
Authors: ERDAŞ KARTAL Eda , MESCİ Günkut
Published: November 2022

This study aims to examine the developments of 50 pre-service teachers' NOSI views during a 14-week implementation in the online outdoor learning environment. This is an experimental study that examines each participant's views and changes about NOSI using an open-ended questionnaire (VASI), and follow-up interviews. The data were analyzed by using content analysis. Almost all participants positively improved their views through the explicit/reflective approach and teachers' own experiences by practicing. In this study, the views of pre-service teachers developed more clearly after preparing lesson plans and their teaching practices. This is an indication that NOSI teaching, which does not provide the experience of conveying their learning outcomes to their practices to the participants is limited on its own and that the importance of “learning through teaching” in teachers' in-service and pre-service training on this subject should not be overlooked. Online teacher education in outdoor learning environments might be used in the development of NOSI views of pre-service teachers. We think that it is important to investigate the effect of this training on teacher education. These types of training might create a more economical and sustainable alternative for the development of NOSI views of wider groups of pre-service and in-service teachers.
Changes to the trading calendar and the day of the week effect in returns and volatility of the Saudi Stock Exchange
Authors: Alsayari Abdulelah , Wickremasinghe Guneratne
Published: November 2022

Until June 29, 2013, the trading days of the Saudi Stock Exchange (TADAWUL) were from Sunday to Wednesday. From June 29, 2013, TADAWUL changed trading days and started trading from Sunday to Thursday. This paper investigates whether this change has impacted the day-of-the-week effect on returns and volatility of the Saudi Stock Exchange. After estimating several GARCH-type models, the EGARCH (2,2) model was selected for the analysis. The study found that the stock return on the week’s first trading day (Saturday) was positive during the previous trading calendar.In contrast, the current trading calendar observed a positive stock return on the last trading day of the week (Thursday). Further, a negative volatility exists at the end of the week during the previous trading calendar. At the beginning of the week, there is a high degree of positive volatility during the current trading calendar. These results indicate that the behavior of stock returns is different between the two trading calendar regimes. In addition, the behavioral patterns on other trading days suggest that the Saudi stock market does not conform to the weak form of the efficient market hypothesis. The above findings indicate that investors in the Saudi stock market could devise trading rules to predict the market index and earn abnormal returns consistently.
Comparison of the blood gas analyser Edan i15 Vet with the blood gas analyser Gem Premier 3000 for the analysis of blood gases, electrolytes, hemoglobin and hematocrit in lactating Holstein
Authors: METIN MERT , AKSOY KEMAL , PEKMEZCI AYTAÇ , DENIZ ABDÜLKERIM
Published: November 2022

A point-of-care blood gas analyser, Edan i15 Vet (EDAN), was compared with a benchtop blood gas analyser, GEM Premier 3000 (GEM). GEM and EDAN were used to analyse whole blood from 123 lactating Holsteins within one month of calving for blood gases, electrolytes, hematocrit and hemoglobin. EDAN and GEM showed significant linear correlations for blood gases, electrolytes, Hct and Hb. The 95% confidence intervals (CI) of intercept in Passing-Bablok regressions included zero in pCO2, bicarbonate, TCO2, BE ecf, BE B, hematocrit, and pH, but not for Na+, K+, pO2 and sO2. The CI of the slope included 1.0 for Na+, K+, pCO2, bicarbonate, TCO2, BE ecf, BE B, hematocrit, and pH, but not for pO2, sO2, and hemoglobin. The Bland-Altman plots between EDAN and GEM showed a bias of 1.4% for Na+, 2.4% for K+, –1.6% for pCO2, 3.0% for pO2, –5.3% for bicarbonate, 2.8% for SO2, –7.3% for TCO2, 10.4% for Hct, 21.2% for Hb, –25.1% for BE B and –38.5% for BE ecf. The biases in the analysis of certain estimated parameters were much higher (> 5%) than for measured parameters except for Hct. Parity did not correlate with blood gas parameters but blood pH correlated negatively with K+, pCO2 and positively with pO2, TCO2, sO2, bicarbonate, BE ecf and BE B. The postpartum time correlated positively with pCO2, TCO2, BE and bicarbonate and negatively with Hct and Hb values. Reference values (2.5-97.5% quartiles) were determined for each parameter. Conclusively, EDAN can be used interchangeably with GEM for the analysis of blood pH, K+, pCO2 and HCO3 – as they show acceptable moderate agreement. However, they did not agree for other parameters such as TCO2, BE ecf, BE B, Hb, Hct, sO2, Na+, and pO2, therefore, reference values for each parameter were set for GEM and EDAN.
White pitahaya as a natural additive: potential usage in cosmetic industry
Authors: Asan-Ozusaglam Meltem , Celik Irem
Published: November 2022

The awareness of some harmful side effects of the chemicals contained in synthetic cosmetics has increased the demand for herbal-based cosmetic products today.

White pitahaya fruit and peel methanol extracts were prepared to determine their usage potential in the cosmetic industry. Firstly, we investigated their antimicrobial activity against some test microorganisms using the disc diffusion assay. We also determined their minimal inhibition and minimal bactericidal or fungicidal concentrations. Then, we assayed the antimicrobial activity of a commercial cream containing white pitahaya extracts and the probiotic Lactobacillus fermentum MA-7 strain against the test microorganisms. Finally, we measured the sun protection factors of the white pitahaya fruit and peel extracts and the cream with the extracts.

The white pitahaya fruit and peel extracts exhibited antimicrobial activity against the test microorganisms. The cream formulation containing a pitahaya fruit extract had the highest inhibition zone diameter of 11.25 mm against Escherichia coli O157:H7. The highest sun protection value among the extracts and cream with extracts was determined for peel extract as 6.66 and 23.34, respectively.

The results indicate that pitahaya fruit and peel extracts have effective antibacterial and antifungal properties, as well as high sun protection factors, and therefore they could be used as natural preservatives in the cosmetic industry.
Applying optimization methods for automatic calibration of 3D morphodynamic numerical models of shallow reservoirs: comparison between lozenge- and hexagon-shaped reservoirs
Authors: Shoarinezhad Vahid , Wieprecht Silke , Kantoush Sameh Ahmed , Haun Stefan
Published: November 2022

Understanding the complexity of the siltation process and sediment resuspension in shallow reservoirs is vital for maintaining the reservoir functionality and implementing sustainable sediment management strategies. The geometry of reservoirs plays an indispensable role in the appearance of various flow structures inside the basin and, consequently, the pattern of the morphological evolution. In this study, a three-dimensional numerical model, coupled with optimization algorithms, is used to investigate the morphological bed changes in two symmetric shallow reservoirs having hexagon and lozenge shapes. This work aims to evaluate the applicability, efficiency, and accuracy of the automatic calibration routine, which can be a suitable replacement for the time-consuming and subjective method of manual model calibration. In this regard, two sensitive parameters (i.e., roughness height and sediment active layer thickness) are assessed. The goodness-of-fit between the calculated bed levels and the measured topography from physical models are presented by different statistical metrics. From the results, it can be concluded that the automatically calibrated models are in reasonable agreement with the observations. Employing a suitable optimization algorithm, which finds the best possible combination of investigated parameters, can considerably reduce the model calibration time and user intervention.
Socioeconomic determinants of water delivery satisfaction in a medium sub-Saharan Africa city: A case of Kisumu, Kenya
Authors: Ocholla Gordon , Letema Sammy , Mireri Caleb
Published: November 2022

The African Commission on Human and Peoples' Rights (Resolution 300) recognizes accessibility to water services as a legal entitlement rather than commodities provided on a charitable basis. However, in Kenya, only 60% of the urban population use safely managed drinking water. This low accessibility of potable water can be linked to socioeconomic disparities among urban dwellers. This article examines how household socioeconomic factors influence water delivery satisfaction in Kisumu city, Kenya. The article is based on a descriptive research design where 384 households were surveyed and ordinal regression was used in data analysis. Water delivery in Kisumu city is characterized by duality where the formal city is supplied by conventional delivery, while the informal settlements are through a pro-poor model. The results of ordinal logistic regression show that significantly (p < 0.01) water affordability is determined by household income (β = 2.10 ∗ 10−5), water accessibility is determined by tenancy (β = 0.483) and household income (β = 2.90 ∗ 10−5), while water reliability is influenced by household income (β = 1.35 ∗ 10−5). Water quality is significantly (p < 0.05) influenced by the level of education (β = 0.260). Gender does not have significant influence on water delivery satisfaction, but the socioeconomic variables are significant predictors of water service delivery in Kisumu city. Therefore, socioeconomic factors should be considered by water utility agencies during water service delivery in the city.
Smart water campus – a testbed for smart water applications
Authors: Oberascher Martin , Kinzel Carolina , Kastlunger Ulrich , Schöpf Martin , Grimm Karl , Plaiasu Daniel , Rauch Wolfgang , Sitzenfrei Robert
Published: November 2022

The Internet of Things concept includes low-cost sensors in combination with innovative wireless communication technology, supporting a large-scale implementation of measurement equipment in the field of urban water infrastructure (UWI). At present, the potentials of such smart solutions are often unclear, making it difficult for decision-makers to justify investments. To address this shortcoming, the Smart Campus is represented as an innovative testbed for smart and data-driven applications in the field of network-based UWI. During the last few years, the campus area of the University of Innsbruck has been comprehensively equipped with a variety of low-cost sensors for monitoring and controlling the UWI in high resolution (1–15 min). The experiences showed that the quality of service is influenced by the choice of communication technology and the installation location, thereby affecting the desired applications. Additionally, water distribution and urban drainage network including nature-based solutions have been integrated into an overall monitored system extended by measures to involve the urban population. This integrative approach allows the usage of synergies for the implementation and supports cross-system improvements (e.g., smart rainwater harvesting). However, an integration of different participants also implies new requirements for the project team (e.g., including social science).
Impact of Dialectical Behavior Therapy on Depression and Anxiety in Patients Following COVID-19 Discharge
Authors: Torbati Abbas Ghodrati , Imeni Maryam , Abbaspour Seddigheh
Published: November 2022

Introduction:

COVID-19 pandemic has a significant impact on mental health including anxiety and depression and can weaken the immune system and make a person more vulnerable to the disease. Psychotherapy techniques have been effective in reducing these disorders. Therefore, this study aimed to investigate the effect of dialectical behavior therapy on depression and anxiety in patients discharged from COVID-19.

Methods:

It was a randomized controlled trial (RCT). The statistical population consisted of 30 men who underwent COVID -19 disease quarantine. Convenience sampling was used and the patients were randomly assigned to experimental and control groups. In the experimental group, dialectical behavior therapy was performed in 10 sessions of 90 minutes. The Beck Depression Inventory (BDI) and the Beck Anxiety Inventory (BAI) were used. Data were analyzed using SPSS 21 software and multivariate analysis of variance.

Results:

There was a significant difference between the mean scores of depression and anxiety in the experimental and control groups (p<0.001). The effect of this treatment on reducing the score of depression was 68% and on reducing the score of anxiety was 54%.

Conclusion:

Dialectical behavior therapy can reduce anxiety and depression in patients with COVID-19 disease. It is suggested that this intervention can be used in psychological treatment programs.
Understanding the basics of content-based marketing and promotion on social media in the technological innovation
Authors: Herdiansyah Dedi , Fahrizal Meizi , Diah Januardi M.
Published: November 2022

Understanding content-based promotion and marketing on various social media is fascinating for academic business people, policymakers, and other business communities. So for that, we discussed it to get that resilience. Our data was obtained electronically by searching on Google Scholar and Google Search for several documents and scientific evidence relevant to answering this study's question. The procedures that we carry out include the following; reviewing data with a data coding system, analyzing data evaluation, and they conclude through interpretation. So that the data we present meets high validity and reality principles. After a series of studies and discussions, the understanding of content-based promotion and marketing on social media in the technological era is a fascinating discussion. This is because the various content published on social media for business promotion has helped business people increase sales and enable their businesses to continue sustainability. Thus, these findings will be helpful in studies and discussions in the academic environment.
Building technology training and student work readiness
Authors:   Department of Building Technology, Covenant University Ota, Ota, Nigeria, Obaju Biodun N. ,   Department of Building Technology, Federal Polytechnic Ede, Ede, Nigeria, Fagbenle Olaposibo I. ,   Department of Building Technology, Covenant University Ota, Ota, Nigeria, Amusan Lekan M. ,   Department of Building Technology, Covenant University Ota, Ota, Nigeria, Musa Shamsudeen ,   Faculty of Built Environment, University of Malaya, Kuala Lumpur 50603, Malaysia,   Department of Building Technology, Federal Polytechnic Ado-Ekiti, Ado-Ekiti, Nigeria
Published: November 2022

The purpose of this study is to examine the readiness of Building technology graduates for the construction industry from four selected Polytechnics in Southwestern Nigeria. With a random sampling technique, a sample of 170 Higher National Diploma Building technology graduates was collected to assess their competence areas in readiness for a future in the construction industry. Results were analyzed using descriptive and inferential statistics (Kruskal-Willis H test). The findings of the study revealed that the level of preparedness of Building graduates for the construction industry is encouraging but shows a declining trend in practical capabilities in carrying out building surveys, preparation of site reports and preparation of reliable estimates for materials, labor and cost of construction works. The study results also presented no significant difference (r>0.05) in the competency of Building technology graduates based on their institutional training in three competency areas (capability to carry setting out of all kinds of buildings, understanding and interpreting structural drawings, understanding, and interpreting architectural drawings). However, the study also presented a significant difference (r<0.005) in seven competency areas of Building technology graduates based on their institutional training. The study recommends curricula restructuring to focus more on practical training and professional collaboration with the industry.
Using inert hot-spots to induce ignition within industrial stockpiles
Authors: Berry Matthew , Nelson Mark , Moores Matthew , Monaghan Brian , Longbottom Raymond
Published: November 2022

The potential for materials undergoing oxidation reactions to spontaneously combust when they are stored in large stockpiles is well known. We consider an application in which such self-heating is desirable and investigate the use of inert hotspots as a means to promote thermal runaway. The size and location of the hotspot are found to have the largest effects on self-heating. Less pronounced are effects due a periodic ambient temperature. The advection velocity through the stockpile can have large effects.