bluuebunny/crossref_metadata_2025 huggingface dataset:
How Wood Quality Can Be Shaped: Results of 70 Years of Experience
Authors: Jelonek Tomasz , Kopaczyk Joanna , Neumann Mathias , Tomczak Arkadiusz , Pazdrowski Witold , Grzywiński Witold , Klimek Katarzyna , Naskrent Bartłomiej , Kuźmiński Robert , Szwed Tomasz
Published: December 2022

This experiment was conducted in the pine woods of central Europe at a research area established in 1951. The experimental area of 1.35 ha was set up in a 14-year-old pine tree stand, which was divided into lots, and the pruning procedure took place in different variants. Some lots constituted control lots without pruned trees. The trees were pruned in four variants, reducing the living tree crown by 1/4, 1/3, 1/2, and 2/3 of its length. The study’s main aim was to determine the influence of pruning forest trees on the tree tissue. Moreover, the study attempted to answer whether pruning was a significant procedure for wood valorisation, and if yes, then which variant was the optimal one for Scots pine growing on the European plain. The results indicated a significant impact of pruning young pine tree stands on the properties of wood tissue, which differed regarding the adopted pruning variant. Significant differences in the width of annual rings, the size of the particular areas of the annual rings (latewood or earlywood), and the wood density depending on the pruning variant were observed. Furthermore, the results indicated that pruning induced numerous processes, which optimised the physiological and mechanical functions of the tree trunks. The outcome of this optimisation was, among others, the diversification of the vascular and strengthening area of the annual ring as well as the wood density, which was a reaction to reducing a part of the assimilation apparatus. From the technical wood value viewpoint, the optimal pruning variant for pine was between 1/3 to 1/2 of the living crown.
Model-Based Identification of Larix sibirica Ledeb. Damage Caused by Erannis jacobsoni Djak. Based on UAV Multispectral Features and Machine Learning
Authors: Ma Lei , Huang Xiaojun , Hai Quansheng , Gang Bao , Tong Siqin , Bao Yuhai , Dashzebeg Ganbat , Nanzad Tsagaantsooj , Dorjsuren Altanchimeg , Enkhnasan Davaadorj , Ariunaa Mungunkhuyag
Published: December 2022

While unmanned aerial vehicle (UAV) remote sensing technology has been successfully used in crop vegetation pest monitoring, a new approach to forest pest monitoring that can be replicated still needs to be explored. The aim of this study was to develop a model for identifying the degree of damage to forest trees caused by Erannis jacobsoni Djak. (EJD). By calculating UAV multispectral vegetation indices (VIs) and texture features (TF), the features sensitive to the degree of tree damage were extracted using the successive projections algorithm (SPA) and analysis of variance (ANOVA), and a one-dimensional convolutional neural network (1D-CNN), random forest (RF), and support vector machine (SVM) were used to construct damage degree recognition models. The overall accuracy (OA), Kappa, Macro-Recall (Rmacro), and Macro-F1 score (F1macro) of all models exceeded 0.8, and the best results were obtained for the 1D-CNN based on the vegetation index sensitive feature set (OA: 0.8950, Kappa: 0.8666, Rmacro: 0.8859, F1macro: 0.8839), while the SVM results based on both vegetation indices and texture features exhibited the poorest performance (OA: 0.8450, Kappa: 0.8082, Rmacro: 0.8415, F1macro: 0.8335). The results for the stand damage level identified by the models were generally consistent with the field survey results, but the results of SVMVIs+TF were poor. Overall, the 1D-CNN showed the best recognition performance, followed by the RF and SVM. Therefore, the results of this study can serve as an important and practical reference for the accurate and efficient identification of the damage level of forest trees attacked by EJD and for the scientific management of forest pests.
Intra- and Interspecific Competition Altered the Competitive Strategies of Alternanthera philoxeroides and Trifolium regens under Cadmium Contamination
Authors: Cui Yuanyuan , Zhang Qiaoying , Tang Tianwen , Deng Xinxin , Zhang Lin , Liu Peng , He Chang , Zhang Yunchun
Published: December 2022

Heavy metal accumulation in soils has been one of the environmental and ecological issues, as it caused life and biodiversity problems. However, many invasive plants can survive in heavy metal polluted areas, but little is known about the invasiveness while under different densities either with native species or themselves. In this study, a greenhouse experiment was performed to examine how cadmium contamination with different concentrations (0, 100, and 200 mg/kg) may influence the interspecific competition between invasive plant Alternanthera philoxeroides and the landscape grass T. regens, as well as the intraspecific competition of A. philoxeroides with different densities. The results showed that stronger interspecific competition would alleviate cadmium damage to both A. philoxeroides and T. regens, but the two species adopted different allocation strategies. A. philoxeroides allocated more biomass to belowground and less to aboveground, while T. regens showed exactly the opposite allocation strategy. There was a significant density effect of intraspecific competition on A. philoxeroides. That is to say, with the increase of A. philoxeroides density, the cadmium stress on the growth of A. philoxeroides decreased. Our findings provide a theoretical basis and technical support for the effective control of A. philoxeroides invasion, as well as the restoration and reconstruction of green vegetation.
Analyzing Fire Severity and Post-Fire Vegetation Recovery in the Temperate Andes Using Earth Observation Data
Authors: Maxwald Melanie , Immitzer Markus , Rauch Hans Peter , Preti Federico
Published: December 2022

In wildfire areas, earth observation data is used for the development of fire-severity maps or vegetation recovery to select post-fire measures for erosion control and revegetation. Appropriate vegetation indices for post-fire monitoring vary with vegetation type and climate zone. This study aimed to select the best vegetation indices for post-fire vegetation monitoring using remote sensing and classification methods for the temperate zone in southern Ecuador, as well as to analyze the vegetation’s development in different fire severity classes after a wildfire in September 2019. Random forest classification models were calculated using the fire severity classes (from the Relativized Burn Ratio—RBR) as a dependent variable and 23 multitemporal vegetation indices from 10 Sentinel-2 scenes as descriptive variables. The best vegetation indices to monitor post-fire vegetation recovery in the temperate Andes were found to be the Leaf Chlorophyll Content Index (LCCI) and the Normalized Difference Red-Edge and SWIR2 (NDRESWIR). In the first post-fire year, the vegetation had already recovered to a great extent due to vegetation types with a short life cycle (seasonal grass-species). Increasing index values correlated strongly with increasing fire severity class (fire severity class vs. median LCCI: 0.9997; fire severity class vs. median NDRESWIR: 0.9874). After one year, the vegetations’ vitality in low severity and moderate high severity appeared to be at pre-fire level.
Physico-Chemical Properties and Storage Stability of an Emulsion as a Fat Replacer in Meat Analogs during the Freezing Storage
Authors: Jeong Hyeseung , Kim Haesanna , Lee Jiseon , Jo Yeon-Ji , Choi Mi-Jung , Ko Eun-Young
Published: December 2022

This study determined the effects of physicochemical and microbial properties of emulsion as a fat replacer in meat analogs during freezing storage. Meat analogs were prepared with different fat replacers: vegetable oil (O) for control, oil in water emulsion (E), and non-emulsified oil in water emulsion (EC) for emulsion control. After that, meat analogs were stored for 0.5, one, three, and six months at −18 °C and −60 °C. The results showed that the drip loss of all samples was not significantly different (p > 0.05). However, the liquid holding capacity of EC and E was significantly higher than that of O (p < 0.05). Additionally, the microstructures of meat analogs of E and EC were smaller with denser pore sizes than O. This explains the significantly lower hardness of E and EC compared to O (p < 0.05). Overall, E showed superior physiochemical and sensory quality. During the storage, the stability of chemical properties, such as volatile basic nitrogen and thiobarbituric acid reactive substances, showed no significant changes (p > 0.05). Moreover, the microbial studies (total viable counts and Escherichia coli count) suggested that meat analogs did not deteriorate during the preparation and storage. Thus, this study suggests that emulsion-type fat replacers influence meat analogs’ physicochemical and sensorial properties. However, these properties are not influenced by the storage temperature and duration.
Socioeconomic Characteristics, Purchasing Preferences and Willingness to Consume Organic Food: A Cross-Location Comparison of Nine Cities in Central Ecuador
Authors: Moreno-Miranda Carlos , Franco-Crespo Christian , Pachucho Isabel , Uño Karla , Gordillo Ana , Ortiz Jacqueline
Published: December 2022

Agriculture worldwide faces the need to reduce chemical pesticides and produce healthier food. In Latin America, research on the organic food sector primarily focuses on supply. Consumption analysis is crucial for providing information about customers’ needs. This paper aims to analyze the Ecuadorian organic food sector, which is an interesting case for investigating the relationship between willingness to consume organic food and socioeconomic factors. To this end, 382 consumers were surveyed. The study applied a logit regression analysis to assess the role of socioeconomic factors in the willingness to consume organic food. Radar diagrams depict the percentage of respondents who checked a particular reason for choosing or refusing organic food. A cross-location comparison analysis was applied to identify differences between locations within the Central Ecuador region. Results reveal that Ecuadorian consumers’ awareness rate of organic food is only 53.5%. Regarding organic food’s price, 24% of consumers perceive it to be overly expensive. Based on strengthening the supervision of organic food production, various channels should be used to promote organic food consumption and facilitate the recognition of available organic food.
Ancient Wheat Varieties and Sourdough Fermentation as a Tool to Increase Bioaccessibility of Phenolics and Antioxidant Capacity of Bread
Authors: Dapčević-Hadnađev Tamara , Stupar Alena , Stevanović Dušan , Škrobot Dubravka , Maravić Nikola , Tomić Jelena , Hadnađev Miroslav
Published: December 2022

This study aimed to determine the impact of ancient wheat varieties (emmer, spelt and khorasan) and spontaneous sourdough fermentation on the bioaccessibility of total phenolic content (TPC) and the DPPH antioxidant capacity evolution during breadmaking and in vitro digestion. Sourdough and yeast-fermented modern wheat breads were used as controls. After 6 h of fermentation, the total titrable acidity of the sourdough increased from 139 to 167%. The wheat variety, type of fermentation and processing affected TPC, antioxidant activity and bioaccessibility. Antioxidant activity and TPC were reduced by dough mixing, increased after sourdough fermentation and slightly decreased or remained the same after baking. Although wheat flour had the highest TPC, the modeling of TPC kinetic revealed that emmer and spelt sourdough exhibited a higher bound phenolics release rate due to the higher acidity, which contributed to increased phenolics solubility. Although wheat bread, both before and after digestion, had the lowest TPC, especially the one prepared with yeast, high TPC bioaccessibilities and antioxidant activities after the digestion suggested that, except phenolics, digestion process improved the release of additional compounds with different bioaccessibility and biological activity. The results of this study proved that the application of sourdough fermentation can increase the potential of ancient wheats in the developing of functional bakery products.
Novel Peptide Sequences with ACE-Inhibitory and Antioxidant Activities Derived from the Heads and Bones of Hybrid Groupers (Epinephelus lanceolatus × Epinephelus fuscoguttatus)
Authors: Chan Pei-Teng , Matanjun Patricia , Budiman Cahyo , Shapawi Rossita , Lee Jau-Shya
Published: December 2022

The heads and bones of hybrid groupers are potential precursors for angiotensin-converting enzyme (ACE)-inhibitory and antioxidant peptides. The aim of this study was to isolate the dual-action peptides from the Alcalase-treated head and bone hydrolysate of hybrid groupers followed by identification of the novel peptides. The stability of these peptides against stimulated in vitro gastrointestinal digestion (SGID) was also determined. Fraction HB-IV (less than 1 kDa) obtained from ultrafiltration showed the strongest ACE-inhibition ability (IC50: 0.28 mg/mL), which was comparable to the potency of the commercial supplement, PeptACE (IC50: 0.22 mg/mL). This fraction also demonstrated the highest hydroxyl radical scavenging and metal-chelating activities. However, further fractionation of HB-IV by a series of chromatography resulted in peptide fractions of reduced ACE-inhibitory and antioxidant activities. The hydroxyl radical scavenging and reduction potential of HB-IV were enhanced, whereas ACE-inhibitory and metal-chelating activities were reduced following SGID. A total of 145 peptide sequences were identified from HB-IV, of which 137 peptides were novel to the BIOPEP database. The results suggested that the bioactive peptides isolated from the heads and bones of hybrid groupers could be used as functional foods/ingredients with potential ACE-inhibitory and antioxidant effects.
Chasing Uterine Cancer with NK Cell-Based Immunotherapies
Authors: Kumar Vijay , Bauer Caitlin , Stewart John H.
Published: December 2022

Gynecological cancers, including endometrial adenocarcinoma, significantly contribute to cancer incidence and mortality worldwide. The immune system plays a significant role in endometrial cancer pathogenesis. NK cells, a component of innate immunity, are among the critical innate immune cells in the uterus crucial in menstruation, embryonic development, and fighting infections. NK cell number and function influence endometrial cancer development and progression. Hence, it becomes crucial to understand the role of local (uterine) NK cells in uterine cancer. Uterine NK (uNK) cells behave differently than their peripheral counterparts; for example, uNK cells are more regulated by sex hormones than peripheral NK cells. A deeper understanding of NK cells in uterine cancer may facilitate the development of NK cell-targeted therapies. This review synthesizes current knowledge on the uterine immune microenvironment and NK cell-targeted uterine cancer therapeutics.
Prenatal Diagnosis of Chromosome 16p11.2 Microdeletion
Authors: Wang You , Zhou Hang , Fu Fang , Cheng Ken , Yu Qiuxia , Huang Ruibin , Lei Tingying , Yang Xin , Li Dongzhi , Liao Can
Published: December 2022

(1) Objective: To investigate the prenatal diagnosis and genetic counseling for 16p11.2 microdeletion syndrome and to evaluate its pregnancy outcome. (2) Methods: This study included 4968 pregnant women who selected invasive prenatal diagnoses from 1 January 2017 to 1 August 2022. These 4698 pregnancies underwent chromosomal microarray analysis (CMA), data on 81 fetuses diagnosed with 16p11.2 microdeletion syndrome based on prenatal ultrasound features and genetic test results were recorded, and their pregnancy outcome was evaluated. (3) Results: 1.63% of fetuses (81/4968) were diagnosed with 16p11.2 microdeletion syndrome. Among these, there were skeletal malformations in 48.15% of the 81 fetuses, cardiovascular malformations in 30.86%, central nervous system malformations (CNS) in 11.11%, digestive system structural abnormalities in 6.17%, and isolated ultrasonography markers in 3.70%. (4) Conclusions: 16p11.2 microdeletion syndrome can display various systemic ultrasound abnormalities in the perinatal period but vertebral malformations are the most common. Our study is the first to report that TBX1 and CJA5 are associated with 16p11.2 microdeletion syndrome, expanding the disease spectrum of 16p11.2 microdeletion syndrome. In our study, the ventricular septal defect is the main feature of cardiac structural abnormalities caused by 16p11.2 microdeletion syndrome. In addition, our study highlights the use of CMA in 16p11.2 microdeletion syndrome, analyzed their genetic results, and evaluated the follow-up prognosis, which can be useful for prenatal diagnosis and genetic counseling.
Trustworthy Breast Ultrasound Image Semantic Segmentation Based on Fuzzy Uncertainty Reduction
Authors: Huang Kuan , Zhang Yingtao , Cheng Heng-Da , Xing Ping
Published: December 2022

Medical image semantic segmentation is essential in computer-aided diagnosis systems. It can separate tissues and lesions in the image and provide valuable information to radiologists and doctors. The breast ultrasound (BUS) images have advantages: no radiation, low cost, portable, etc. However, there are two unfavorable characteristics: (1) the dataset size is often small due to the difficulty in obtaining the ground truths, and (2) BUS images are usually in poor quality. Trustworthy BUS image segmentation is urgent in breast cancer computer-aided diagnosis systems, especially for fully understanding the BUS images and segmenting the breast anatomy, which supports breast cancer risk assessment. The main challenge for this task is uncertainty in both pixels and channels of the BUS images. In this paper, we propose a Spatial and Channel-wise Fuzzy Uncertainty Reduction Network (SCFURNet) for BUS image semantic segmentation. The proposed architecture can reduce the uncertainty in the original segmentation frameworks. We apply the proposed method to four datasets: (1) a five-category BUS image dataset with 325 images, and (2) three BUS image datasets with only tumor category (1830 images in total). The proposed approach compares state-of-the-art methods such as U-Net with VGG-16, ResNet-50/ResNet-101, Deeplab, FCN-8s, PSPNet, U-Net with information extension, attention U-Net, and U-Net with the self-attention mechanism. It achieves 2.03%, 1.84%, and 2.88% improvements in the Jaccard index on three public BUS datasets, and 6.72% improvement in the tumor category and 4.32% improvement in the overall performance on the five-category dataset compared with that of the original U-shape network with ResNet-101 since it can handle the uncertainty effectively and efficiently.
Florentine Normative Values for Physical Fitness in Adolescents Aged 14–15 Years
Authors: Mascherini Gabriele , Buglione Niccolò , Ciani Virginia , Tirinnanzi Franco , Bini Vittorio , Levi Micheli Matteo
Published: December 2022

Physical fitness during youth is linked to the health of today’s young people and future adults. Therefore, fitness evaluation can direct any physical exercise interventions and verify improvements. The study aims to provide normative values of the physical fitness of the Florentine adolescent population. This cross-sectional study enrolled 1915 subjects aged 14 and 15 from the first and second high school classes. Tests were performed to assess cardiovascular endurance, upper and lower limb strength, running speed and agility, and lower limb muscle flexibility. Sex and age-related percentiles were elaborated. The study included 1028 subjects in the first class (aged 14.3 ± 0.8 years; 54.5% females) and 887 in the second class (aged 15.3 ± 0.7 years; 53.4% females). Males showed higher values than females except for flexibility. Furthermore, both genders show increased results in transitioning from the first to the second class, except for muscle flexibility and running speed. The percentiles of the present study provide normative values of the physical fitness of the 14–15-year-old Florentine adolescent population. These results, characterized by a sociocultural specificity linked to the territory from which they were collected, can contribute to the assessment and improvement of the physical status of young people, promoting current and future health.
The Experiences and Views on Palliative Care of Older People with Multimorbidities, Their Family Caregivers and Professionals in a Spanish Hospital
Authors: Llop-Medina Laura , Ródenas-Rigla Francisco , Garcés-Ferrer Jorge , Doñate-Martínez Ascensión
Published: December 2022

The increasing prevalence of complex chronic diseases in the population over 65 years of age is causing a major impact on health systems. This study aims to explore the needs and preferences of the multimorbid patient and carers to improve the palliative care received. The perspective of professionals who work with this profile of patients was also taken into account. A qualitative study was conducted using semi-structured interviews with open-ended questions. Separate topic guides were developed for patients, careers and health professionals. We included 12 patients, 11 caregivers and 16 health professionals in Spain. The results showed multiple unmet needs of patients and families/caregivers, including feelings of uncertainty, a sense of fear, low awareness and knowledge about palliative care in non-malignant settings, and a desire to improve physical, psychosocial and financial status. A consistent lack of specialized psychosocial care for both patients and caregivers was expressed and professionals highlighted the need for holistic needs assessment and effective and early referral pathways to palliative care. There is a lack of institutional support for multimorbid older patients in need of palliative care and important barriers need to be addressed by health systems to face the significant increase in these patients.
Long-Term Effect of COVID-19 on Lung Imaging and Function, Cardiorespiratory Symptoms, Fatigue, Exercise Capacity, and Functional Capacity in Children and Adolescents: A Systematic Review and Meta-Analysis
Authors: Campos Catherine , Prokopich Samantha , Loewen Hal , Sanchez-Ramirez Diana C.
Published: December 2022

Background: The long-term sequela of COVID-19 on young people is still unknown. This systematic review explored the effect of COVID-19 on lung imaging and function, cardiorespiratory symptoms, fatigue, exercise capacity and functional capacity in children and adolescents ≥ 3 months after infection. Methods: A systemic search was completed in the electronic databases of PubMed, Web of Science and Ovid MEDLINE on 27 May 2022. Data on the proportion of participants who had long-term effects were collected, and one-group meta-analysis were used to estimate the pooled prevalence of the outcomes studied. Results: 17 articles met the inclusion criteria, presented data on 124,568 children and adolescents. The pooled prevalence of abnormalities in lung imaging was 10% (95% CI 1–19, I2 = 73%), abnormal pulmonary function was 24% (95% CI 4–43, I2 = 90%), chest pain/tightness was 6% (95% CI 3–8, I2 = 100%), heart rhythm disturbances/palpitations was 6% (95% CI 4–7, I2 = 98%), dyspnea/breathing problems was 16% (95% CI 14–19, I2 = 99%), and fatigue was 24% (95% CI 20–27, I2 = 100%). Decreased exercise capacity and functional limitations were found in 20% (95% CI 4–37, I2 = 88%) and 48% (95% CI 25–70, I2 = 91%) of the participants studied, respectively. Conclusion: Children and adolescents may have persistent abnormalities in lung imaging and function, cardiorespiratory symptoms, fatigue, and decreased functional capacity between 3 to 12 months after infection. More research is needed to understand the long-term effect of COVID-19 on young people, and to clarify its causes and effective management.
Economics of Artificial Intelligence in Healthcare: Diagnosis vs. Treatment
Authors: Khanna Narendra N. , Maindarkar Mahesh A. , Viswanathan Vijay , Fernandes Jose Fernandes E , Paul Sudip , Bhagawati Mrinalini , Ahluwalia Puneet , Ruzsa Zoltan , Sharma Aditya , Kolluri Raghu , Singh Inder M. , Laird John R. , Fatemi Mostafa , Alizad Azra , Saba Luca , Agarwal Vikas , Sharma Aman , Teji Jagjit S. , Al-Maini Mustafa , Rathore Vijay , Naidu Subbaram , Liblik Kiera , Johri Amer M. , Turk Monika , Mohanty Lopamudra , Sobel David W. , Miner Martin , Viskovic Klaudija , Tsoulfas George , Protogerou Athanasios D. , Kitas George D. , Fouda Mostafa M. , Chaturvedi Seemant , Kalra Mannudeep K. , Suri Jasjit S.
Published: December 2022

Motivation: The price of medical treatment continues to rise due to (i) an increasing population; (ii) an aging human growth; (iii) disease prevalence; (iv) a rise in the frequency of patients that utilize health care services; and (v) increase in the price. Objective: Artificial Intelligence (AI) is already well-known for its superiority in various healthcare applications, including the segmentation of lesions in images, speech recognition, smartphone personal assistants, navigation, ride-sharing apps, and many more. Our study is based on two hypotheses: (i) AI offers more economic solutions compared to conventional methods; (ii) AI treatment offers stronger economics compared to AI diagnosis. This novel study aims to evaluate AI technology in the context of healthcare costs, namely in the areas of diagnosis and treatment, and then compare it to the traditional or non-AI-based approaches. Methodology: PRISMA was used to select the best 200 studies for AI in healthcare with a primary focus on cost reduction, especially towards diagnosis and treatment. We defined the diagnosis and treatment architectures, investigated their characteristics, and categorized the roles that AI plays in the diagnostic and therapeutic paradigms. We experimented with various combinations of different assumptions by integrating AI and then comparing it against conventional costs. Lastly, we dwell on three powerful future concepts of AI, namely, pruning, bias, explainability, and regulatory approvals of AI systems. Conclusions: The model shows tremendous cost savings using AI tools in diagnosis and treatment. The economics of AI can be improved by incorporating pruning, reduction in AI bias, explainability, and regulatory approvals.
Educational Needs in Oncology Nursing: A Scoping Review
Authors: Solera-Gómez Silvia , Benedito-Monleón Amparo , LLinares-Insa Lucía Inmaculada , Sancho-Cantus David , Navarro-Illana Esther
Published: December 2022

Care in oncology requires both technical and psychosocial skills by nursing staff, so continuous learning is necessary. Evidence suggests there are some educational gaps in oncology nursing staff, and continuing educational interventions have been effective in overcoming these deficiencies. Aim: to determine the basic educational lines that a continuous training program should have for oncology nurses. A bibliographic review study was carried out in two phases from October 2020 to January 2021. In a first phase, the main databases were analyzed: PubMed, Web of Science, Dialnet and Medline, following the PRISMA methodology; and subsequently, an analysis of the most important thematic nuclei that a training program in cancer nursing should contain. The DAFO matrix and the Hanlon prioritization method were used. Four competencies that every oncology nurse should have were described: communication, coping, self-direction of learning and technical health. The thematic contents that a training program should contain were then determined, and aspects such as stress prevention and burnout, adequate communication with patient and family, and continuous educational and technical skills were considered. The results found suggest that there are deficiencies in the education of nursing staff. Continuing education programs are effective in supplementing them. They should develop the four skills described in the results section.
Failure in Medical Practice: Human Error, System Failure, or Case Severity?
Authors: Roman Mihai Dan , Fleacă Sorin Radu , Boicean Adrian Gheorghe , Mohor Cosmin Ioan , Morar Silviu , Dura Horatiu , Cristian Adrian Nicolae , Bratu Dan , Tanasescu Ciprian , Teodoru Adrian , Necula Radu , Russu Octav
Published: December 2022

The success rate in medical practice will probably never reach 100%. Success rates depend on many factors. Defining the success rate is both a technical and a philosophical issue. In opposition to the concept of success, medical failure should also be discussed. Its causality is multifactorial and extremely complex. Its actual rate and its real impact are unknown. In medical practice, failure depends not only on the human factor but also on the medical system and has at its center a very important variable—the patient. To combat errors, capturing, tracking, and analyzing them at an institutional level are important. Barriers such as the fear of consequences or a specific work climate or culture can affect this process. Although important data regarding medical errors and their consequences can be extracted by analyzing patient outcomes or using quality indicators, patient stories (clinical cases) seem to have the greatest impact on our subconscious as medical doctors and nurses and these may generate the corresponding and necessary reactions. Every clinical case has its own story. In this study, three different cases are presented to illustrate how human error, the limits of the system, and the particularities of the patient’s condition (severity of the disease), alone or in combination, may lead to tragic outcomes There is a need to talk openly and in a balanced way about failure, regardless of its cause, to look at things as they are, without hiding the inconvenient truth. The common goal is not to find culprits but to find solutions and create a culture of safety.
Hydrological and Hydraulic Modeling Applied to Flash Flood Events in a Small Urban Stream
Authors: Bruno Leonardo Souza , Mattos Tiago Souza , Oliveira Paulo Tarso Sanches , Almagro André , Rodrigues Dulce Buchala Bicca
Published: December 2022

In flood area mapping studies, hydrological-hydraulic modeling has been successfully applied around the world. However, the object of study of most of the research developed in Brazil is medium to large channels that use topographical and hydrometeorological data of coarse spatial and temporal resolution. Thus, the aim of this study is to investigate coupled modeling in a small urban channel, using high-resolution data, in the simulation of flood events in a small urban channel, located in Campo Grande, Mato Grosso do Sul. In this study, we used the HEC-HMS and HEC-RAS programs, where topographic information, land use, land cover, and observed data from rain gauges, water level, and flow sensors from 2015 to 2018 were used as input data. To calibrate and validate the hydrological model, four events were used that occurred during the monitoring period, while in the hydraulic model we chose a historical event that caused great disturbances. We then generated flood scenarios with representative synthetic rainfall for a basin, with return times of 5, 10, 50, and 100 years. We observed a good fit in the calibration and validation of the HEC-HMS, with values of R2 = 0.93, RMSE = 1.29, and NSE = 0.92. In HEC-RAS, we obtained values of R2 = 0.93, RMSE = 1.29, and NSE = 0.92 for the calibration, and in the validation, real images of the event prove the computed flood spot sources. We observed that rain with a return time of less than five years provides areas of flooding in several regions of the channel, and in critical channeled sections, the elevation and speed of the flow reach 5 m and 3 m·s−1, respectively. Our results indicate that the channel already has a natural tendency towards flooding in certain stretches, which become more compromised due to land use and coverage and local conditions. We conclude that the high-resolution coupled modeling generated information that represents local conditions as well, showing how potential failures of drainage in extreme scenarios are possible, thus enabling the planning of adaptations and protection measures against floods.
Effects of Digital Transformation on Environmental Governance of Mining Enterprises: Evidence from China
Authors: Xu Chaohui , Chen Xingtong , Dai Wei
Published: December 2022

Digitization offers fresh impetus to the transformation and upgrading of mining enterprises, while on the other hand, the rapid development and broad application of digital technologies make the environmental governance of mining enterprises the most important themes of theoretical research and practical exploration. In this paper, A-share companies listed between 2007 and 2020 are taken as samples to study the influence of digital transformation on the environmental governance of mining enterprises, and its relative acting paths. Our main research methods are multiple linear regression analysis, the panel fixed-effect model and the intermediary effect model. The results show that digital transformation significantly improves the environmental governance of mining enterprises, which is still tenable even after going through a series of endogeneity and robustness tests. It is found via the path test that, by strengthening the supervision of the media, the digital transformation performed in mining enterprises helps improve their environmental governance level, but the comparability of the accounting data shows no significant mediation effect between digital transformation and environmental governance. The heterogeneity test found that the promotion of digital transformation in environmental governance was significant only in non-state-owned enterprises, large-scale enterprises, and mature-growth enterprises. The findings enrich studies on the economic consequences and the environmental governance influences brought by mining enterprise’s transformation based on advanced technologies. This provides an important reference and is of great heuristic significance in promoting digital transformation and strengthening the environmental governance of mining enterprises.
Politics in Search of Evidence—The Role of Public Health in the COVID Pandemic in Germany: Protocol for a Situational Analysis
Authors: Piel Julia , von Köppen Marilena , Apfelbacher Christian
Published: December 2022

The protocol presents a research project that explores the relationship between science and politics in the COVID-19 pandemic from the perspective of public health (PH) scientists in Germany with situational analysis (SA). In context of this global crisis, we ask how PH scientists negotiate their roles as scientists and political citizens; how PH scientists perceive the relationship between their own and other scientific disciplines; and which normative assumptions PH scientists make in the production and dissemination of research findings. To conduct SA, we combine qualitative interviews with PH experts and published documents from scientific societies in PH and related disciplines (e.g., position and opinion papers) to analyze the complexity of integrating evidence-based knowledge into politics. Data are analyzed using different SA mapping tools, focusing on social worlds/arena maps and positional maps. The approach will reveal both explicit positions in the PH community and implicit or hidden voices and will reflect normative assumptions as well as internal structures of PH in Germany. The findings will be discussed with the philosophy sub-project and in a stakeholder workshop with politicians and the public. Further insights will be gained for politics and PH responses to future global crises.
Risk Factors Associated with Preventable Hospitalisation among Rural Community-Dwelling Patients: A Systematic Review
Authors: Ridge Andrew , Peterson Gregory M. , Nash Rosie
Published: December 2022

Potentially preventable hospitalisations (PPHs) are common and increase the burden on already stretched healthcare services. Increasingly, psychosocial factors have been recognised as contributing to PPHs and these may be mitigated through greater attention to social capital. This systematic review investigates the factors associated with PPHs within rural populations. The review was designed, conducted, and reported according to PRISMA guidelines and registered with Prospero (ID: CRD42020152194). Four databases were systematically searched, and all potentially relevant papers were screened at the title/abstract level, followed by full-text review by at least two reviewers. Papers published between 2000–2022 were included. Quality assessment was conducted using Newcastle–Ottawa Scale and CASP Qualitative checklist. Of the thirteen papers included, eight were quantitative/descriptive and five were qualitative studies. All were from either Australia or the USA. Access to primary healthcare was frequently identified as a determinant of PPH. Socioeconomic, psychosocial, and geographical factors were commonly identified in the qualitative studies. This systematic review highlights the inherent attributes of rural populations that predispose them to PPHs. Equal importance should be given to supply/system factors that restrict access and patient-level factors that influence the ability and capacity of rural communities to receive appropriate primary healthcare.
Potentiometric MIP-Modified Screen-Printed Cell for Phenoxy Herbicides Detection
Authors: Zanoni Camilla , Spina Stefano , Magnaghi Lisa Rita , Guembe-Garcia Marta , Biesuz Raffaela , Alberti Giancarla
Published: December 2022

In this study, a molecularly imprinted polymer (MIP)-based screen-printed cell is developed for detecting phenoxy herbicides using 2-methyl-4-chlorophenoxyacetic acid (MCPA) as the template. MCPA is a phenoxy herbicide widely used since 1945 to control broadleaf weeds via growth regulation, primarily in pasture and cereal crops. The potentiometric cell consists of a silver/silver chloride pseudo-reference electrode and a graphite working electrode coated with a MIP film. The polymeric layer is thermally formed after drop-coating of a pre-polymeric mixture composed of the reagents at the following molar ratio: 1 MCPA: 15 MAA (methacrylic acid): 7 EGDMA (ethylene glycol dimethacrylate). After template removal, the recognition cavities function as the ionophore of a classical ion selective electrode (ISE) membrane. The detected ion is the deprotonated MCPA specie, negatively charged, so the measurements were performed in phosphate buffer at pH 5.5. A linear decrease of the potential with MCPA concentration, ranging from 4 × 10−8 to 1 × 10−6 mol L−1, was obtained. The detection limit and the limit of quantification were, respectively, 10 nmol L−1 and 40 nmol L−1. A Nernstian slope of about −59 mV/dec was achieved. The method has precision and LOD required for MCPA determination in contaminated environmental samples.
Effect of a Cognitive Function and Social Skills-Based Digital Exercise Therapy Using IoT on Motor Coordination in Children with Intellectual and Developmental Disability
Authors: Park Seung-Bo , Ju Yumi , Kwon Hyunjin , Youm Heeok , Kim Min Joo , Chung Jinwook
Published: December 2022

This study aimed to determine the effects of a virtual reality exercise program based on cognitive function and social skills on motor coordination in children with intellectual and developmental disabilities (IDD). Thirty-five children with IDD were randomly assigned to either the cognitive function and social skills-based virtual reality exercise system (CS-VR) group or the conventional virtual reality exercise system (C-VR) group. Before and after the intervention, each participant was tested for motor coordination (extended horizontal jump, hop, stationary dribble, overarm throw) and exercise performance (standing long jump, YMCA step test). Compared with the C-VR group, the CS-VR group showed significant improvements in motor coordination in terms of extended horizontal jump, hop, and overarm throw (p < 0.01, p < 0.05, and p < 0.01, respectively). In addition, compared with the C-VR group, the CS-VR group showed a significant increase in standing long jump (p < 0.01), although no significant between-group variation was found in stationary dribble and recovery heart rate (RHR) as part of the YMCA step test (p > 0.05, and p > 0.05, respectively). These results suggest that for the development of motor skills in children with IDD, it is essential to develop an exercise program that reflects the levels of cognitive functions and social skills of these children.
Microbial Contamination of Bedding Material: One Health in Poultry Production
Authors: Gomes Bianca , Pena Pedro , Cervantes Renata , Dias Marta , Viegas Carla
Published: December 2022

In poultry farms, the mixture of bedding material, chicken excrement, and feathers seems to play an important role in pathogen development which may contribute to a potential risk of zoonosis, spreading the disease through the food chain. The purpose of this study was to analyze microbial contamination in bedding material and other matrices as well as potential antimicrobial resistances in chicken production facilities, and also to identify the sampling techniques and assays used. This study evidences the available data published, following the PRISMA methodology. Among the environmental samples, surface swabs were frequently used as a passive sampling technique. Morphological identification was performed in all studies. From all the matrices, the bedding material was the most contaminated. Most studies focused on bacterial contamination, with Salmonella sp. and Campylobacter sp. being commonly reported and three studies evidenced fungal contamination, being Penicillium sp.- and Aspergillus sp.-dominant. Mycotoxin assessment was only performed in one study, being identified in all bedding samples. The screening for bacteria resistance evidenced bacteria multidrug resistance; however, fungal susceptibility to azoles was not assessed in any of the analyzed studies. Briefly, this review evidences the microbial contamination in poultry facilities, emphasizing animals’ bedding as a potential source of contamination. Additionally, this study contributes to a sampling and analysis protocol proposal to assess the microbial contamination in this setting. Additionally, the knowledge gaps identified highlight the need of further research regarding microbial contamination and toxicological potential on animals’ bedding in order to mitigate the exposure in poultry pavilions.
Are Old Men Impotent? On a Sparse Discourse of Early Modern Medicine and Its Forensic Implications in Paolo Zacchia’s Quaestiones medico-legales
Authors: Schäfer Daniel
Published: December 2022

In early modern medical literature, there are increasing references to sterility and impotence in older men. This is especially true of the Quaestiones medico-legales by the Roman physician Paolo Zacchia (1584–1659). In several books of this systematically structured manual, its author discusses medical and legal arguments on the one hand. On the other hand, in the 10th, only posthumously published volume, a total of five cases of impotence in old men are described on the basis of court decisions of the Rota Romana and expert opinions of the author. The paper examines these cases with regard to central statements on male impotence in old age, which are placed in the medical as well as the social and legal-historical context of the time. It becomes clear that old-age impotence and sterility were less a medical than a legal problem in the 17th century. However, the physician Zacchia emphasises the concept of biological age instead of historically transmitted numerical age limits. In this respect, his expert opinions already show the first signs of medical empiricism.
Bariatric Surgery: Psychosocial Aspects and Quality of Life
Authors: Martinelli Valentina , Chiappedi Matteo
Published: December 2022

Obesity is a major worldwide health problem, causing an ongoing and decades-long pandemic, which the WHO has termed the “global obesity epidemic”, concurrent with the COVID-19 pandemic [...]
Changes in the Serum Concentration Levels of Serotonin, Tryptophan and Cortisol among Stress-Resilient and Stress-Susceptible Individuals after Experiencing Traumatic Stress
Authors: Ogłodek Ewa Alicja
Published: December 2022

Background: Stress is a common response to many environmental adversities. However, once dysregulated, this reaction can lead to psychiatric illnesses, such as post-traumatic stress disorder (PTSD). Individuals can develop PTSD after exposure to traumatic events, severely affecting their quality of life. Nevertheless, not all individuals exposed to stress will develop psychiatric disorders, provided they show enhanced stress-resilience mechanisms that enable them to successfully adapt to stressful situations and thus avoid developing a persistent psychopathology. Methods: The study involved 93 participants. Of them, 62 comprised a study group and 31 comprised a control group. The aim of the study was to assess serotonin, cortisol and tryptophan concentration levels in subjects with PTSD (stress-susceptible; PTSD-SS) and in healthy individuals (stress-resilient; PTSD-SR), who had experienced a traumatic event but fully recovered after the trauma. The subjects were between 18 and 50 years of age (mean 35.56 ± 8.26 years). The serum concentration levels of serotonin, cortisol and tryptophan were measured with an ELISA kit. Results: It was found that the serotonin, tryptophan and cortisol concentration levels were consistent with the features of both PTSD-SR and PTSD-SS patients. It was reported that the mean cortisol concentration levels increased more significantly in the PTSD-SS group than in the PTSD-SR group, versus those in the control group. Similarly, the PTSD-SS group was found to show a larger decrease in the mean serotonin concentration levels than the PTSD-SR group, versus those in the control group. No significant changes were found in the tryptophan concentration levels between the study groups, versus those in the control group. Conclusions: These findings can be useful when attempting to improve resilience in individuals using neuropharmacological methods. However, it is necessary to conduct more cross-sectional studies that would address different types of negative stress to find out whether they share common pathways.