bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations Between Air Temperature and Daily Suicide Counts in Astana, Kazakhstan
Authors: Grjibovski Andrej , Kozhakhmetova Gulmira , Kosbayeva Aliya , Menne Bettina
Published: April 2018

Background and Objective. Seasonal variations in suicide mortality and its association with ambient air temperature have been observed in many countries. However, the evidence from Central Asia is scarce. The aim of the study was to assess the relationship between 4 indicators of air temperature and daily suicide counts in Astana, Kazakhstan. Material and Methods. The daily counts of suicides (ICD-10 codes, X60–X84) for the population of Astana in 2005–2010 were collected using death certificates and medical records at the Municipal Bureau of Forensic Medicine. Associations between the number of cases and mean, maximum, mean apparent, and maximum apparent temperatures were studied using negative binomial regression models controlling for the effects of month, year, weekends, holidays, wind velocity, barometric pressure, and relative humidity. Results. Altogether, there were 685 suicides in Astana in 2005–2010. A clear seasonal pattern with the peak in summer was observed. In crude analyses, significant associations between suicide counts and all 4 temperatures were found. After adjustment for other variables, only apparent temperatures remained significantly associated with the outcome. An increase in the mean apparent temperature by 1°C was associated with an increase in suicide counts by 2.1% (95% CI, 0.4–3.8). Similar results were obtained for the maximum apparent temperature (1.2%, 95% CI, 0.1–2.3). Conclusions. The results suggest a linear relationship between apparent temperatures and daily suicide counts across the whole spectrum of temperatures. Factors behind this association need further research with a further going aim to develop mitigation strategies in the period of climate change.
Inhibition of Dendritic L-Type Calcium Current by Memantine in Frog Tectum
Authors: Baginskas Armantas , Kuras Antanas , Grigaliūnas Artūras
Published: April 2018

The aim of the study was to explore the effects of memantine on responses elicited in the frog tectum by the bursts of spikes of moderate strength of a single retina ganglion cell and to gain an insight about the effect of memantine on the L-type Ca2+ current. Material and Methods. The experiments were performed in vivo on adult frogs (Rana temporaria). An individual retina ganglion cell (or its retinotectal fiber) was stimulated by current pulses delivered through a multichannel stimulating electrode positioned on the retina. Responses to the discharge of a single retinal ganglion cell were recorded in the tectum by an extracellular carbonfiber microelectrode positioned in the terminal arborization of the retinotectal fiber in the tectum layer F. The solution of memantine (1-amino-3,5-dimethyladamantane) hydrochloride (30 or 45 μM) was applied onto the surface of the tectum by perfusion at a rate of 0.4 mL/min. Results. Memantine (30–45 μM) largely inhibited the L-type Ca2+ channel-mediated slow negative wave and late discharges seen in the tectum responses without any effect on fast synaptic retinotectal transmission. Conclusions. Our results suggest that the neuroprotective effect of memantine could arise not only through the inhibition of the NMDA receptor current but also through the suppression of the L-type Ca2+ current.
In Situ Formation of TiB2/Al2O3-Reinforced Fe3Al by Combustion Synthesis with Thermite Reduction
Authors: Yeh Chun-Liang , Ke Chih-Yao
Published: April 2018

Fabrication of Fe3Al–TiB2–Al2O3 composites with a broad range of phase compositions was studied by combustion synthesis involving aluminothermic reduction of oxide precursors. Two reaction systems composed of elemental Fe, amorphous boron, and a thermite mixture of Fe2O3/TiO2/Al were conducted in the mode of self-propagating high-temperature synthesis (SHS). One was to produce the composites of 1.25Fe3Al + xTiB2 + Al2O3 with x = 0.3–1.0. The other was to fabricate the products of yFe3Al + 0.6TiB2 + Al2O3 with y = 1.0–1.6. Reduction of Fe2O3 by Al acted as an initiation step to activate the SHS process. Complete phase conversion from the reactants to Fe3Al–TiB2–Al2O3 composites was achieved. The variation of combustion front velocity with sample stoichiometry was consistent with that of the reaction exothermicity. Based on combustion wave kinetics, the activation energy of Ea = 86.8 kJ/mol was determined for formation of the Fe3Al–TiB2–Al2O3 composite through the thermite-based SHS reaction. In addition, with an increase in TiB2, the fracture toughness of the 1.25Fe3Al + xTiB2 + Al2O3 composite was found to increase from 5.32 to 7.92 MPa·m1/2.
Archaean Gold Mineralization in an Extensional Setting: The Structural History of the Kukuluma and Matandani Deposits, Geita Greenstone Belt, Tanzania
Authors: Kwelwa Shimba , Dirks Paulus , Sanislav Ioan , Blenkinsop Thomas , Kolling Sergio
Published: April 2018

Three major gold deposits, Matandani, Kukuluma, and Area 3, host several million ouncez (Moz) of gold, along a ~5 km long, WNW trend in the E part of the Geita Greenstone Belt, NW Tanzania. The deposits are hosted in Archaean volcanoclastic sediment and intrusive diorite. The geological evolution of the deposits involved three separate stages: (1) an early stage of syn-sedimentary extensional deformation (D1) around 2715 Ma; (2) a second stage involving overprinting ductile folding (D2–4) and shearing (D5–6) events during N-S compression between 2700 and 2665 Ma, coeval with the emplacement of the Kukuluma Intrusive Complex; and (3) a final stage of extensional deformation (D7) accommodated by minor, broadly east-trending normal faults, preceded by the intrusion of felsic porphyritic dykes at ~2650 Ma. The geometry of the ore bodies at Kukuluma and Matandani is controlled by the distribution of magnetite-rich meta-ironstone, near the margins of monzonite-diorite bodies of the Kukuluma Intrusive Complex. The lithological contacts acted as redox boundaries, where high-grade mineralization was enhanced in damage zones with higher permeability, including syn-D3 hydrothermal breccia, D2–D3 fold hinges, and D6 shears. The actual mineralizing event was syn-D7, and occurred in an extensional setting that facilitated the infiltration of mineralizing fluids. Thus, whilst gold mineralization is late-tectonic, ore zone geometries are linked to older structures and lithological boundaries that formed before gold was introduced. The deformation-intrusive history of the Kukuluma and Matandani deposits is near identical to the geological history of the world-class Nyankanga and Geita Hill deposits in the central part of the Geita Greenstone Belt. This similarity suggests that the geological history of much of the greenstone belt is similar. All major gold deposits in the Geita Greenstone Belt lack close proximity to crustal-scale shear zones; they are associated with intrusive complexes and volcanics that formed in an oceanic plateau rather than subduction setting, and formed late-tectonically during an extensional phase. They are not characteristic of typical orogenic gold deposits.
Insights into the Surface Transformation and Electrochemical Dissolution Process of Bornite in Bioleaching
Authors: Zhao Hongbo , Huang Xiaotao , Hu Minghao , Zhang Chenyang , Zhang Yisheng , Wang Jun , Qin Wenqing , Qiu Guanzhou
Published: April 2018

In this work, density functional theory (DFT) calculations, X-ray photoelectron spectroscopy (XPS) and electrochemistry analysis were combined to analyze the electrochemical dissolution process of bornite during bioleaching. DFT calculations showed that bornite was a conductor with metallic conductivity. The formula of bornite may be (Cu+)5Fe3+(S2−)4 and the surface reconstruction of (111)-S surface was discussed. Electrochemistry and XPS analysis showed that bornite tended to be directly oxidized with high conductivity when the potential was higher than 0.3 V vs. Ag/AgCl. Elemental sulfur (S0), FeOOH and CuS were the main intermediate species on the bornite surface during the oxidation process. The production of S0 and FeOOH on bornite surface can be significantly accelerated with increased redox potential, but no insoluble sulfate (SO42−) formed on bornite surface in 0.3–0.65 V vs. Ag/AgCl. The oxidative dissolution of bornite was significantly accelerated with increasing redox potential, which was one important reason why mixed culture was more effective than single strains of A. caldus and L. ferriphilum in bornite bioleaching. The insoluble SO42− was formed mainly through the chemical reactions in solution and then covered the bornite surface in bioleaching. Based on the obtained results, a model for interpreting the dissolution process of bornite in bioleaching was proposed.
Investigation on Species Authenticity for Herbal Products of Celastrus Orbiculatus and Tripterygum Wilfordii from Markets Using ITS2 Barcoding
Authors: Zhang Jingjing , Hu Xin , Wang Ping , Huang Bisheng , Sun Wei , Xiong Chao , Hu Zhigang , Chen Shilin
Published: April 2018

Herbal material is both a medicine and a commodity. Accurate identification of herbal materials is necessary to ensure the safety and effectiveness of medication. With this work, we initiated an identification method to investigate the species authenticity for herbal products of Celastrus orbiculatus and Tripterygum wilfordii utilizing DNA barcoding technology. An ITS2 (internal transcribed spacer two) barcode database including 59 sequences was successfully established to estimate the reliability of species-level identification for Celastrus and Tripterygium. Our findings showed that ITS2 can effectively and clearly distinguish C. orbiculatus, T. wilfordii and its congeners. Then, we investigated the proportions and varieties of adulterant species in the herbal markets. The data from ITS2 region indicated that 13 (62%) of the 21 samples labeled as “Nan-she-teng” and eight (31%) of the 26 samples labeled as “Lei-gong-teng” were authentic; the remaining were adulterants. Of the 47 herbal products, approximately 55% of the product identity were not in accordance with the label. In summary, we support the efficacy of the ITS2 barcode for the traceability of C. orbiculatus and T. wilfordii, and the present study provides one method and reference for the identification of the herbal materials and adulterants in the medicinal markets.
Self-Assembly Behavior of Amphiphilic Janus Dendrimers in Water: A Combined Experimental and Coarse-Grained Molecular Dynamics Simulation Approach
Authors: Elizondo-García Mariana E. , Márquez-Miranda Valeria , Araya-Durán Ingrid , Valencia-Gallegos Jesús A. , González-Nilo Fernando D.
Published: April 2018

Amphiphilic Janus dendrimers (JDs) are repetitively branched molecules with hydrophilic and hydrophobic components that self-assemble in water to form a variety of morphologies, including vesicles analogous to liposomes with potential pharmaceutical and medical application. To date, the self-assembly of JDs has not been fully investigated thus it is important to gain insight into its mechanism and dependence on JDs’ molecular structure. In this study, the aggregation behavior in water of a second-generation bis-MPA JD was evaluated using experimental and computational methods. Dispersions of JDs in water were carried out using the thin-film hydration and ethanol injection methods. Resulting assemblies were characterized by dynamic light scattering, confocal microscopy, and atomic force microscopy. Furthermore, a coarse-grained molecular dynamics (CG-MD) simulation was performed to study the mechanism of JDs aggregation. The obtaining of assemblies in water with no interdigitated bilayers was confirmed by the experimental characterization and CG-MD simulation. Assemblies with dendrimersome characteristics were obtained using the ethanol injection method. The results of this study establish a relationship between the molecular structure of the JD and the properties of its aggregates in water. Thus, our findings could be relevant for the design of novel JDs with tailored assemblies suitable for drug delivery systems.
Microbial Oxidation of the Fusidic Acid Side Chain by Cunninghamella echinulata
Authors: Ibrahim Abdel-Rahim S. , Elokely Khaled M. , Ferreira Daneel , Ragab Amany E.
Published: April 2018

Biotransformation of fusidic acid (1) was accomplished using a battery of microorganisms including Cunninghamella echinulata NRRL 1382, which converted fusidic acid (1) into three new metabolites 2–4 and the known metabolite 5. These metabolites were identified using 1D and 2D NMR and HRESI-FTMS data. Structural assignment of the compounds was supported via computation of 1H- and 13C-NMR chemical shifts. Compounds 2 and 3 were assigned as the 27-hydroxy and 26-hydroxy derivatives of fusidic acid, respectively. Subsequent oxidation of 3 afforded aldehyde 4 and the dicarboxylic acid 5. Compounds 2, 4 and 5 were screened for antimicrobial activity against different Gram positive and negative bacteria, Mycobacterium smegmatis, M. intercellulare and Candida albicans. The compounds showed lower activity compared to fusidic acid against the tested strains. Molecular docking studies were carried out to assist the structural assignments and predict the binding modes of the metabolites.
Antioxidant and Cytoprotective Effects of Kukoamines A and B: Comparison and Positional Isomeric Effect
Authors: Li Xican , Lin Jian , Chen Ban , Xie Hong , Chen Dongfeng
Published: April 2018

In this study, two natural phenolic polyamines, kukoamine A and B, were comparatively investigated for their antioxidant and cytoprotective effects in Fenton-damaged bone marrow-derived mesenchymal stem cells (bmMSCs). When compared with kukoamine B, kukoamine A consistently demonstrated higher IC50 values in PTIO•-scavenging (pH 7.4), Cu2+-reducing, DPPH•-scavenging, •O2−-scavenging, and •OH-scavenging assays. However, in the PTIO•-scavenging assay, the IC50 values of each kukoamine varied with pH value. In the Fe2+-chelating assay, kukoamine B presented greater UV-Vis absorption and darker color than kukoamine A. In the HPLC–ESI–MS/MS analysis, kukoamine A with DPPH• produced radical-adduct-formation (RAF) peaks (m/z 922 and 713). The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay suggested that both kukoamines concentration-dependently increased the viabilities of Fenton-damaged bmMSCs at 56.5–188.4 μM. However, kukoamine A showed lower viability percentages than kukoamine B. In conclusion, the two isomers kukoamine A and B can protect bmMSCs from Fenton-induced damage, possibly through direct or indirect antioxidant pathways, including electron-transfer, proton-transfer, hydrogen atom transfer, RAF, and Fe2+-chelating. Since kukoamine B possesses higher potentials than kukoamine A in these pathways, kukoamine B is thus superior to kukoamine A in terms of cytoprotection. These differences can ultimately be attributed to positional isomeric effects.
Novel Inhibitor Discovery of Staphylococcus aureus Sortase B and the Mechanism Confirmation via Molecular Modeling
Authors: Wang Guizhen , Wang Xiyan , Sun Lin , Gao Yawen , Niu Xiaodi , Wang Hongsu
Published: April 2018

SortaseB (SrtB) plays a critical role in Staphylococcus aureus (S. aureus) infections. According to the reports in the literature, SrtB can anchor the IsdC to the cell wall to capture iron from the host to achieve a successful invasion. On the other hand, SrtB could also affect the adhesion of S. aureus to host cells based on previous studies. Here, we report about a novel SrtB inhibitor, coptisine, a natural compound that does not exhibit antibacterial activity but can inhibit the SrtB activity in vitro. A cytotoxicity test indicated that coptisine protects human lung epithelial cells from S. aureus. In addition, coptisine can reduce the adhesion of S. aureus to human lung epithelial cells based on the result of plate colony counting assay. Molecular dynamics simulation revealed that coptisine can bind to the active pocket of SrtB, leading to its activity loss. Through the calculation of binding free energy between ligand and protein, site-directed mutagenesis and fluorescence spectroscopy quenching methods, it was confirmed that residues of Arg115, Asn116, and Ile182 played a vital role in the interaction of SrtB with coptisine. These data provide the theoretical basis for the therapy option to the infections caused by S. aureus.
Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus
Authors: Alahdal Abdulrahman , Asfour Hani , Ahmed Safwat , Noor Ahmad , Al-Abd Ahmed , Elfaky Mahmoud , Elhady Sameh
Published: April 2018

The Red Sea specimen of the marine sponge Hyrtios erectus (order Dictyoceratida) was found to contain scalarane-type sesterterpenes. 12-O-deacetyl-12,19-di-epi-scalarin (14), a new scalarane sesterterpenoid, along with fourteen previously-reported scalarane-type sesterterpenes (1–13 and 15) have been isolated. The chemical structures of the isolated compounds were elucidated on the basis of detailed 1D and 2D NMR spectral data and mass spectroscopy, as well as by comparison with reported data. The anti-Helicobacter pylori, antitubercular and cytotoxic activities of all fifteen compounds were evaluated to reveal the potency of Compounds 1, 2, 3, 4, 6, 7 and 10. Amongst these, Compounds 1, 3, 4, 6 and 10 displayed a promising bioactivity profile, possessing potent activities in the antitubercular and anti-H. pylori bioassay. Compounds 2 and 7 showed the most promising cytotoxic profile, while Compounds 1 and 10 showed a moderate cytotoxic profile against MCF-7, HCT-116 and HepG2 cell lines.
Synthesis of a 1,2-Dithienylethene-Containing Donor-Acceptor Polymer via Palladium-Catalyzed Direct Arylation Polymerization (DArP)
Authors: Wakioka Masayuki , Yamashita Natsumi , Mori Hiroki , Nishihara Yasushi , Ozawa Fumiyuki
Published: April 2018

This paper reports the synthesis of D-A polymers containing 1,2-dithienylethene (DTE) units via palladium-catalyzed direct arylation polymerization (DArP). The reaction of dibromoisoindigo (1-Br) and DTE (2-H), in the presence of Pd2(dba)3·CHCl3 (0.5 mol%), P(2-MeOC6H4)3 (L1) (2 mol%), pivalic acid (1 equiv) as catalyst precursors, and Cs2CO3 (3 equiv) as a base affords poly(1-alt-2) with a high molecular weight (Mn up to 44,900). Although, it has been known that monomers, with plural C–H bonds, tend to form insoluble materials via direct arylation at undesirable C–H positions; the reaction of 1-Br and 2-H cleanly proceeds without insolubilization. The resulting polymer has a well-controlled structure and exhibits good charge transfer characteristics in an organic field-effect transistor (OFET), compared to the polymer produced by Migita–Kosugi–Stille cross-coupling polymerization. The DArP product displays an ideal linear relationship in the current–voltage curve, whereas the Migita–Kosugi–Stille product shows a VG-dependent change in the charge mobility.
Plasma and Salivary Non-Urate Total Antioxidant Capacity Does Not Depend on Dietary Vitamin C, E, or β-Carotene Intake in Older Subjects
Authors: Gawron-Skarbek Anna , Guligowska Agnieszka , Prymont-Przymińska Anna , Nowak Dariusz , Kostka Tomasz
Published: April 2018

The native Total Antioxidant Capacity (TAC) of plasma and saliva is generally determined by uric acid (UA). Several studies have assessed the impact of habitual dietary antioxidative vitamin intake on TAC, but it remains unknown whether it influences Non-Urate Total Antioxidant Capacity (Nu-TAC), i.e., TAC after enzymatic UA elimination. The purpose of this study was to assess whether the intake of antioxidative vitamins C, E, and β-carotene, provided with usual daily food rations, affects plasma and salivary Nu-TAC. The study involved 56 older subjects (aged 66.9 ± 4.3 years), divided into two age- and sex-matched groups: group 1 (n = 28), with lower combined vitamin C, E, and β-carotene intake, and group 2 (n = 28), with higher intake. A 24 h dietary recall was obtained from each individual. Nu-TAC was assessed simultaneously with two methods in plasma (Ferric Reducing Ability of Plasma—Nu-FRAP, 2.2-diphenyl-1-picryl-hydrazyl—Nu-DPPH) and in saliva (Nu-FRAS and Nu-DPPHS test). No differences were found in the Nu-TAC parameters between the groups, either in plasma (Nu-FRAP, Nu-DPPH) or in saliva (Nu-FRAS, Nu-DPPHS) (p > 0.05). No plasma or salivary Nu-TAC indices correlated with dietary vitamin C, E, or β-carotene intake or with other nutrients. Habitual, not extra-supplemented dietary intake does not significantly affect plasma or salivary Nu-TAC.
Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds from Three Myrcia Species
Authors: Dos Santos Catarina , Galaverna Renan S. , Angolini Celio F. F. , Nunes Vania V. A. , De Almeida Luiz F. R. , Ruiz Ana L. T. G. , De Carvalho João E. , Duarte Regina M. T. , Duarte Marta C. T. , Eberlin Marcos N.
Published: April 2018

Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(−)Q-TOF-MS. The main constituents found were ellagic acid (M. bella), galloyl glucose isomers (M. guianensis) and hexahydroxydiphenic (HHDP) acid derivatives (M. fallax). In addition, quercetin and myricetin derivatives were also found in all Myrcia spp. extracts. The most promising antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, was found for M. fallax extracts (EC50 8.61 ± 0.22 µg·mL−1), being slightly less active than quercetin and gallic acid (EC50 2.96 ± 0.17 and 2.03 ± 0.02 µg·mL−1, respectively). For in vitro antiproliferative activity, M. guianensis showed good activity against leukemia (K562 TGI = 7.45 µg·mL−1). The best antimicrobial activity was observed for M. bella and M. fallax to Escherichia coli (300 and 250 µg·mL−1, respectively). In conclusion, the activities found are closely related to the phenolic composition of these plants.
A Facile Method for the Preparation of Colored Bi4Ti3O12−x Nanosheets with Enhanced Visible-Light Photocatalytic Hydrogen Evolution Activity
Authors: Zhang Yizeng , Chen Zhiwu , Lu Zhenya
Published: April 2018

Bi4Ti3O12−x nanosheet photocatalysts with abundant oxygen vacancies are fabricated by a facile solid-state chemical reduction method for the first time. This method is simple in operation, has short reaction time, and can be conducted at mild temperatures (300~400 °C). The electron paramagnetic resonance, thermogravimetric analysis, X-ray photoelectron spectrometer, and positron annihilation lifetime spectra results indicate that oxygen vacancies are produced in Bi4Ti3O12−x, and they can be adjusted by tuning the reduction reaction conditions. Control experiments show that the reduction time and temperature have great influences on the photocatalytic activities of Bi4Ti3O12−x. The optimal Bi4Ti3O12−x is the sample undergoing the reduction treatment at 350 °C for 60 min and it affords a hydrogen evolution rate of 129 μmol·g−1·h−1 under visible-light irradiation, which is about 3.4 times that of the pristine Bi4Ti3O12. The Bi4Ti3O12−x photocatalysts have good reusability and storage stability and can be used to decompose formaldehyde and formic acid for hydrogen production. The surface oxygen vacancies states result in the broadening of the valence band and the narrowing of the band gap. Such energy level structure variation helps promote the separation of photo-generated electron-hole pairs thus leading to enhancement in the visible-light photocatalytic hydrogen evolution. Meanwhile, the narrowing of the band gap leads to a broader visible light absorption of Bi4Ti3O12−x.
Effect of Organic Substrates on the Photocatalytic Reduction of Cr(VI) by Porous Hollow Ga2O3 Nanoparticles
Authors: Liu Jin , Gan Huihui , Wu Hongzhang , Zhang Xinlei , Zhang Jun , Li Lili , Wang Zhenling
Published: April 2018

Porous hollow Ga2O3 nanoparticles were successfully synthesized by a hydrolysis method followed by calcination. The prepared samples were characterized by field emission scanning electron microscope, transmission electron microscope, thermogravimetry and differential scanning calorimetry, UV-vis diffuse reflectance spectra and Raman spectrum. The porous structure of Ga2O3 nanoparticles can enhance the light harvesting efficiency, and provide lots of channels for the diffusion of Cr(VI) and Cr(III). Photocatalytic reduction of Cr(VI), with different initial pH and degradation of several organic substrates by porous hollow Ga2O3 nanoparticles in single system and binary system, were investigated in detail. The reduction rate of Cr(VI) in the binary pollutant system is markedly faster than that in the single Cr(VI) system, because Cr(VI) mainly acts as photogenerated electron acceptor. In addition, the type and concentration of organic substrates have an important role in the photocatalytic reduction of Cr(VI).
Electrically and Thermally Conductive Low Density Polyethylene-Based Nanocomposites Reinforced by MWCNT or Hybrid MWCNT/Graphene Nanoplatelets with Improved Thermo-Oxidative Stability
Authors: Paszkiewicz Sandra , Szymczyk Anna , Pawlikowska Daria , Subocz Jan , Zenker Marek , Masztak Roman
Published: April 2018

In this paper, the electrical and thermal conductivity and morphological behavior of low density polyethylene (LDPE)/multi-walled carbon nanotubes (MWCNTs) + graphene nanoplatelets (GNPs) hybrid nanocomposites (HNCs) have been studied. The distribution of MWCNTs and the hybrid of MWCNTs/GNPs within the polymer matrix has been investigated with scanning electron microscopy (SEM). The results showed that the thermal and electrical conductivity of the LDPE-based nanocomposites increased along with the increasing content of carbon nanofillers. However, one could observe greater improvement in the thermal and electrical conductivity when only MWCNTs have been incorporated. Moreover, the improvement in tensile properties and thermal stability has been observed when carbon nanofillers have been mixed with LDPE. At the same time, the increasing content of MWCNTs and MWCNTs/GNPs caused an increase in the melt viscosity with only little effect on phase transition temperatures.
Photoinduced Glycerol Oxidation over Plasmonic Au and AuM (M = Pt, Pd and Bi) Nanoparticle-Decorated TiO2 Photocatalysts
Authors: Jedsukontorn Trin , Saito Nagahiro , Hunsom Mali
Published: April 2018

In this study, sol-immobilization was used to prepare gold nanoparticle (Au NP)-decorated titanium dioxide (TiO2) photocatalysts at different Au weight % (wt. %) loading (Aux/TiO2, where x is the Au wt. %) and Au–M NP-decorated TiO2 photocatalysts (Au3M3/TiO2), where M is bismuth (Bi), platinum (Pt) or palladium (Pd) at 3 wt. %. The Aux/TiO2 photocatalysts exhibited a stronger visible light absorption than the parent TiO2 due to the localized surface plasmon resonance effect. Increasing the Au content from 1 wt. % to 7 wt. % led to increased visible light absorption due to the increasing presence of defective structures that were capable of enhancing the photocatalytic activity of the as-prepared catalyst. The addition of Pt and Pd coupled with the Au3/TiO2 to form Au3M3/TiO2 improved the photocatalytic activity of the Au3/TiO2 photocatalyst by maximizing their light-absorption property. The Au3/TiO2, Au3Pt3/TiO2 and Au3Pd3/TiO2 photocatalysts promoted the formation of glyceraldehyde from glycerol as the principle product, while Au3Bi3/TiO2 facilitated glycolaldehyde formation as the major product. Among all the prepared photocatalysts, Au3Pd3/TiO2 exhibited the highest photocatalytic activity with a 98.75% glycerol conversion at 24 h of reaction time.
On a Molecular Basis, Investigate Association of Molecular Structure with Bioactive Compounds, Anti-Nutritional Factors and Chemical and Nutrient Profiles of Canola Seeds and Co-Products from Canola Processing: Comparison Crusher Plants within Canada and within China as well as between Canada and China
Authors: Gomaa Walaa M. S. , Mosaad Gamal M. , Yu Peiqiang
Published: April 2018

The objectives of this study were to: (1) Use molecular spectroscopy as a novel technique to quantify protein molecular structures in relation to its chemical profiles and bioenergy values in oil-seeds and co-products from bio-oil processing. (2) Determine and compare: (a) protein molecular structure using Fourier transform infrared (FT/IR-ATR) molecular spectroscopy technique; (b) bioactive compounds, anti-nutritional factors, and chemical composition; and (c) bioenergy values in oil seeds (canola seeds), co-products (meal or pellets) from bio-oil processing plants in Canada in comparison with China. (3) Determine the relationship between protein molecular structural features and nutrient profiles in oil-seeds and co-products from bio-oil processing. Our results showed the possibility to characterize protein molecular structure using FT/IR molecular spectroscopy. Processing induced changes between oil seeds and co-products were found in the chemical, bioenergy profiles and protein molecular structure. However, no strong correlation was found between the chemical and nutrient profiles of oil seeds (canola seeds) and their protein molecular structure. On the other hand, co-products were strongly correlated with protein molecular structure in the chemical profile and bioenergy values. Generally, comparisons of oil seeds (canola seeds) and co-products (meal or pellets) in Canada, in China, and between Canada and China indicated the presence of variations among different crusher plants and bio-oil processing products.
Design and Reproducibility of a Mini-Survey to Evaluate the Quality of Food Intake (Mini-ECCA) in a Mexican Population
Authors: Bernal-Orozco María Fernanda , Badillo-Camacho Nayeli , Macedo-Ojeda Gabriela , González-Gómez Montserrat , Orozco-Gutiérrez Jaime Fernando , Prado-Arriaga Ruth Jackelyne , Márquez-Sandoval Fabiola , Altamirano-Martínez Martha Betzaida , Vizmanos Barbara
Published: April 2018

Evaluating food intake quality may contribute to the development of nutrition programs. In Mexico, there are no screening tools that can be administered quickly for the evaluation of this variable. The aim was to determine the reproducibility of a mini-survey designed to evaluate the quality of food intake (Mini-ECCA) in a Mexican population. Mini-ECCA consists of 12 questions that are based on Mexican and international recommendations for food and non-alcoholic beverage intake, with the support of photographs for food quantity estimation. Each question scores as 0 (unhealthy) or 1 (healthy), and the final score undergoes a classification procedure. Through the framework of a nutritional study, 152 employees of the municipal water company in Guadalajara, Mexico (April–August 2016), were invited to participate. The survey was administered in two rounds (test and retest) with a 15-day interval between them. We calculated the Spearman correlation coefficient, the intra-class correlation coefficient (ICC), and weighted kappa for score classification agreement (SPSS versus 14 p < 0.05 was considered statistically significant). The survey obtained a “good” reproducibility (ρ = 0.713, p < 0.001), and an excellent concordance (ICC = 0.841 Confidence Interval 95% 0.779, 0.885). It can thus be said that the Mini-ECCA displayed acceptable reproducibility and is suitable for the purpose of dietary assessment and guidance.
Effects of Chlorogenic Acid-Enriched and Hydroxyhydroquinone-Reduced Coffee on Postprandial Fat Oxidation and Antioxidative Capacity in Healthy Men: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial
Authors: Katada Shun , Watanabe Takuya , Mizuno Tomohito , Kobayashi Shinichi , Takeshita Masao , Osaki Noriko , Kobayashi Shigeru , Katsuragi Yoshihisa
Published: April 2018

Chlorogenic acids (CGAs) reduce blood pressure and body fat, and enhance fat metabolism. In roasted coffee, CGAs exist together with the oxidant component hydroxyhydroquinone (HHQ). HHQ counteracts the antihypertensive effects of CGA, but its effects on CGA-induced fat oxidation (FOX) are unknown. Here we assessed the effects of CGA-enriched and HHQ-reduced coffee on FOX. Fifteen healthy male volunteers (age: 38 ± 8 years (mean ± SD); BMI: 22.4 ± 1.5 kg/m2) participated in this crossover study. Subjects consumed the test beverage (coffee) containing the same amount of CGA with HHQ (CGA-HHQ(+)) or without HHQ (CGA-HHQ(−)) for four weeks. Postprandial FOX and the ratio of the biological antioxidant potential (BAP) to the derivatives of reactive oxygen metabolites (d-ROMs) as an indicator of oxidative stress were assessed. After the four-week intervention, postprandial FOX and the postprandial BAP/d-ROMs ratio were significantly higher in the CGA-HHQ(−) group compared with the CGA-HHQ(+) group (4 ± 23 mg/min, group effect: p = 0.040; 0.27 ± 0.74, group effect: p = 0.007, respectively). In conclusion, reducing the amount of HHQ facilitated the postprandial FOX effects of CGA in coffee. Our findings also suggest that the mechanism underlying the inhibition of FOX by HHQ is related to postprandial oxidative stress.
Library-Mediated Deposit: A Gift to Researchers or a Curse on Open Access? Reflections from the Case of Surrey
Authors: Daoutis Christine Antiope , Rodriguez-Marquez Maria de Montserrat
Published: April 2018

The University of Surrey was one of the first universities to set up an open access repository. The Library was the natural stakeholder to lead this project. Over the years, the service has been influenced by external and internal factors, and consequently the Library’s role in developing the OA agenda has changed. Here, we present the development and implementation of a fully mediated open access service at Surrey. The mediated workflow was introduced following an operational review, to ensure higher compliance and engagement from researchers. The size and responsibilities of the open access team in the Library increased to comply with internal and external policies and to implement the fully mediated workflow. As a result, there has been a growth in deposit rates and overall compliance. We discuss the benefits and shortcomings of Library mediation; its effects on the relationship between the Library, senior management and researchers, and the increasing necessity for the Library to lead towards a culture of openness beyond policy compliance.
Active Management of Operational Risk in the Regimes of the “Unknown”: What Can Machine Learning or Heuristics Deliver?
Authors: Milkau Udo , Bott Jürgen
Published: April 2018

Advanced machine learning has achieved extraordinary success in recent years. “Active” operational risk beyond ex post analysis of measured-data machine learning could provide help beyond the regime of traditional statistical analysis when it comes to the “known unknown” or even the “unknown unknown.” While machine learning has been tested successfully in the regime of the “known,” heuristics typically provide better results for an active operational risk management (in the sense of forecasting). However, precursors in existing data can open a chance for machine learning to provide early warnings even for the regime of the “unknown unknown.”
Spatial Downscaling of Gross Primary Productivity Using Topographic and Vegetation Heterogeneity Information: A Case Study in the Gongga Mountain Region of China
Authors: Xie Xinyao , Li Ainong , Jin Huaan , Yin Gaofei , Bian Jinhu
Published: April 2018

Due to the spatial heterogeneity of land surfaces, downscaling is an important issue in the development of carbon cycle models when evaluating the role of ecosystems in the global carbon cycle. In this study, a downscaling algorithm was developed to model gross primary productivity (GPP) at 500 m in a time series over rugged terrain, which considered the effects of spatial heterogeneity on carbon flux simulations. This work was carried out for a mountainous area with an altitude ranging from 2606 to 4744 m over the Gongga Mountain (Sichuan Province, China). In addition, the Moderate Resolution Imaging Spectroradiometer (MODIS) GPP product at 1 km served as the primary dataset for the downscaling algorithm, and the 500 m MODIS GPP product was used as the reference dataset to evaluate the downscaled GPP results. Moreover, in order to illustrate the advantages and benefits of the proposed downscaling method, the downscaled results in this work, along with ordinary kriging downscaled results, spline downscaled results and inverse distance weighted (IDW) downscaled results, were compared to the MODIS GPP at 500 m. The results showed that (1) the GPP difference between the 500 m MODIS GPP and the proposed downscaled GPP results was primarily in the range of [−1, 1], showing that both vegetation heterogeneity factors (i.e., LAI) and topographic factors (i.e., altitude, slope and aspect) were useful for GPP downscaling; (2) the proposed downscaled results (R2 = 0.89, RMSE = 1.03) had a stronger consistency with the 500 m MODIS GPP than those of the ordinary kriging downscaled results (R2 = 0.43, RMSE = 1.36), the spline downscaled results (R2 = 0.40, RMSE = 1.50) and the IDW downscaled results (R2 = 0.42, RMSE = 1.10) for all Julian days; and (3) the inconsistency between MODIS GPP at 500 m and 1 km increased with the increase in altitude and slope. The proposed downscaling algorithm could provide a reference when considering the effects of spatial heterogeneity on carbon flux simulations and retrieving other fine resolution ecological-physiology parameters (e.g., net primary productivity and evaporation) over topographically complex terrains.
Salient Object Detection via Recursive Sparse Representation
Authors: Zhang Yongjun , Wang Xiang , Xie Xunwei , Li Yansheng
Published: April 2018

Object-level saliency detection is an attractive research field which is useful for many content-based computer vision and remote-sensing tasks. This paper introduces an efficient unsupervised approach to salient object detection from the perspective of recursive sparse representation. The reconstruction error determined by foreground and background dictionaries other than common local and global contrasts is used as the saliency indication, by which the shortcomings of the object integrity can be effectively improved. The proposed method consists of the following four steps: (1) regional feature extraction; (2) background and foreground dictionaries extraction according to the initial saliency map and image boundary constraints; (3) sparse representation and saliency measurement; and (4) recursive processing with a current saliency map updating the initial saliency map in step 2 and repeating step 3. This paper also presents the experimental results of the proposed method compared with seven state-of-the-art saliency detection methods using three benchmark datasets, as well as some satellite and unmanned aerial vehicle remote-sensing images, which confirmed that the proposed method was more effective than current methods and could achieve more favorable performance in the detection of multiple objects as well as maintaining the integrity of the object area.
Measurements on the Absolute 2-D and 3-D Localization Accuracy of TerraSAR-X
Authors: Balss Ulrich , Gisinger Christoph , Eineder Michael
Published: April 2018

The German TerraSAR-X radar satellites TSX-1 and TDX-1 are well-regarded for their unprecedented geolocation accuracy. However, to access their full potential, Synthetic Aperture Radar (SAR)-based location measurements have to be carefully corrected for effects that are well-known in the area of geodesy but were previously often neglected in the area of SAR, such as wave propagation and Earth dynamics. Our measurements indicate that in this way, when SAR is handled as a geodetic measurement instrument, absolute localization accuracy at better than centimeter level with respect to a given geodetic reference frame is obtained in 2-D and, when using stereo SAR techniques, also in 3-D. The TerraSAR-X measurement results presented in this study are based on a network of three globally distributed geodetic observatories. Each is equipped with one or two trihedral corner reflectors with accurately (<5 mm) known reference coordinates, used as a reference for the verification of the SAR measured coordinates. Because these observatories are located in distant parts of the world, they give us evidence on the worldwide reproducibility of the obtained results. In this paper we report the achieved results of measurements performed over 6 1/2 years (from July 2011 to January 2018) and refer to some first new application areas for geodetic SAR.
Estimation of Above Ground Biomass in a Tropical Mountain Forest in Southern Ecuador Using Airborne LiDAR Data
Authors: González-Jaramillo Víctor , Fries Andreas , Zeilinger Jörg , Homeier Jürgen , Paladines-Benitez Jhoana , Bendix Jörg
Published: April 2018

A reliable estimation of Above Ground Biomass (AGB) in Tropical Mountain Forest (TMF) is still complicated, due to fast-changing climate and topographic conditions, which modifies the forest structure within fine scales. The variations in vertical and horizontal forest structure are hardly detectable by small field plots, especially in natural TMF due to the high tree diversity and the inaccessibility of remote areas. Therefore, the present approach used remotely sensed data from a Light Detection and Ranging (LiDAR) sensor in combination with field measurements to estimate AGB accurately for a catchment in the Andes of south-eastern Ecuador. From the LiDAR data, information about horizontal and vertical structure of the TMF could be derived and the vegetation at tree level classified, differentiated between the prevailing forest types (ravine forest, ridge forest and Elfin Forest). Furthermore, topographical variables (Topographic Position Index, TPI; Morphometric Protection Index, MPI) were calculated by means of the high-resolution LiDAR data to analyse the AGB distribution within the catchment. The field measurements included different tree parameters of the species present in the plots, which were used to determine the local mean Wood Density (WD) as well as the specific height-diameter relationship to calculate AGB, applying regional scale modelling at tree level. The results confirmed that field plot measurements alone cannot capture completely the forest structure in TMF but in combination with high resolution LiDAR data, applying a classification at tree level, the AGB amount (Mg ha−1) and its distribution in the entire catchment could be estimated adequately (model accuracy at tree level: R2 > 0.91). It was found that the AGB distribution is strongly related to ridges and depressions (TPI) and to the protection of the site (MPI), because high AGB was also detected at higher elevations (up to 196.6 Mg ha−1, above 2700 m), if the site is situated in depressions (ravine forest) and protected by the surrounding terrain. In general, highest AGB is stored in the protected ravine TMF parts, also at higher elevations, which could only be detected by means of the remote sensed data in high resolution, because most of these areas are inaccessible. Other vegetation units, present in the study catchment (pasture and subpáramo) do not contain large AGB stocks, which underlines the importance of intact natural forest stands.
Dual-Task Elderly Gait of Prospective Fallers and Non-Fallers: A Wearable-Sensor Based Analysis
Authors: Howcroft Jennifer , Lemaire Edward , Kofman Jonathan , McIlroy William
Published: April 2018

Wearable sensors could facilitate point of care, clinically feasible assessments of dynamic stability and associated fall risk through an assessment of single-task (ST) and dual-task (DT) walking. This study investigated gait changes between ST and DT walking and between older adult prospective fallers and non-fallers. The results were compared to a study based on retrospective fall occurrence. Seventy-five individuals (75.2 ± 6.6 years; 47 non-fallers, 28 fallers; 6 month prospective fall occurrence) walked 7.62 m under ST and DT conditions while wearing pressure-sensing insoles and accelerometers at the head, pelvis, and on both shanks. DT-induced gait changes included changes in temporal measures, centre of pressure (CoP) path stance deviations and coefficient of variation, acceleration descriptive statistics, Fast Fourier Transform (FFT) first quartile, ratio of even to odd harmonics, and maximum Lyapunov exponent. Compared to non-fallers, prospective fallers had significantly lower DT anterior–posterior CoP path stance coefficient of variation, DT head anterior–posterior FFT first quartile, ST left shank medial–lateral FFT first quartile, and ST right shank superior maximum acceleration. DT-induced gait changes were consistent regardless of faller status or when the fall occurred (retrospective or prospective). Gait differences between fallers and non-fallers were dependent on retrospective or prospective faller identification.
Sigma Routing Metric for RPL Protocol
Authors: Sanmartin Paul , Rojas Aldo , Fernandez Luis , Avila Karen , Jabba Daladier , Valle Sebastian
Published: April 2018

This paper presents the adaptation of a specific metric for the RPL protocol in the objective function MRHOF. Among the functions standardized by IETF, we find OF0, which is based on the minimum hop count, as well as MRHOF, which is based on the Expected Transmission Count (ETX). However, when the network becomes denser or the number of nodes increases, both OF0 and MRHOF introduce long hops, which can generate a bottleneck that restricts the network. The adaptation is proposed to optimize both OFs through a new routing metric. To solve the above problem, the metrics of the minimum number of hops and the ETX are combined by designing a new routing metric called SIGMA-ETX, in which the best route is calculated using the standard deviation of ETX values between each node, as opposed to working with the ETX average along the route. This method ensures a better routing performance in dense sensor networks. The simulations are done through the Cooja simulator, based on the Contiki operating system. The simulations showed that the proposed optimization outperforms at a high margin in both OF0 and MRHOF, in terms of network latency, packet delivery ratio, lifetime, and power consumption.
OFDM with Index Modulation for Asynchronous mMTC Networks
Authors: Doğan Seda , Tusha Armed , Arslan Hüseyin
Published: April 2018

One of the critical missions for next-generation wireless communication systems is to fulfill the high demand for massive Machine-Type Communications (mMTC). In mMTC systems, a sporadic transmission is performed between machine users and base station (BS). Lack of coordination between the users and BS in time destroys orthogonality between the subcarriers, and causes inter-carrier interference (ICI). Therefore, providing services to asynchronous massive machine users is a major challenge for Orthogonal Frequency Division Multiplexing (OFDM). In this study, OFDM with index modulation (OFDM-IM) is proposed as an eligible solution to alleviate ICI caused by asynchronous transmission in uncoordinated mMTC networks. In OFDM-IM, data transmission is performed not only by modulated subcarriers but also by the indices of active subcarriers. Unlike classical OFDM, fractional subcarrier activation leads to less ICI in OFDM-IM technology. A novel subcarrier mapping scheme (SMS) named as Inner Subcarrier Activation is proposed to further alleviate adjacent user interference in asynchronous OFDM-IM-based systems. ISA reduces inter-user interference since it gives more activation priority to inner subcarriers compared with the existing SMS-s. The superiority of the proposed SMS is shown through both theoretical analysis and computer-based simulations in comparison to existing mapping schemes for asynchronous systems.