bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on the Application of Blackboard Writing Images in College English Writing Teaching Aided by “POA” Theory
Authors: Du Haixia
Published: August 2022

English is the most widely used language in the world as an official language and the most widely used language in the world as a second language. Writing ability is one of the five basic skills of English learners. Writing a beautiful English article has high requirements on the learners’ thinking, vocabulary, grammar, organization, and appropriateness. Research shows that for most English learners, English writing is the most difficult, and learners generally have problems in writing, such as incoherent expression, poor logic, single structure, and lack of interest. In addition, the domestic English writing teaching mode still has the problem of “ignoring the output and focusing on the input”, which leads to poor teaching effect and the students’ writing level cannot be effectively improved. In response to the above problems, this paper proposes to design a college English writing teaching plan based on the output-oriented approach (POA), focusing on the three core teaching links of driving, facilitating, and evaluating. Analytical research is conducted. Experiments show that the effectiveness of blackboard writing image teaching and English writing teaching under the theory of “production-oriented approach” has been significantly improved.
A Diversified Integration Method of IPE Teaching Resources Based on Ant Colony Algorithm
Authors: Shan Song , Li Shuxiang
Published: August 2022

In the era of big data, cloud computing, and machine learning, this has become essential to promote the better development of ideological and political education (IPE) in institutions and universities. In fact, we must pay close devotion to the integration and utilization of online teaching resources, take full benefits of the assistances of big data, machine learning, and continuously collect and sort resources that are conducive to IPE in higher vocational academies, so as to optimize the educational process. In fact, the resource allocation within the context of the IPE is not well-addressed in the existing literature; and the allocation of resources is quite unreasonable. In higher vocational education, the form and content of the IPE will enhance its effectiveness. In this paper, we use the ant colony algorithm to efficiently obtain the solution set for resource allocation, thereby addressing the issues of unreasonable allocation of IPE resources and inefficient testing. In addition, the local search method is incorporated into the ant colony optimization technique to perform a local search on the solution set of the obtained resource allocation in order to increase the algorithm’s performance. On the standard test set, algorithm comparison experimentations are carried out to validate the efficacy and efficiency of the suggested algorithm.
Application of Art Activities in Colleges and Universities Based on BP Neural Network Algorithm
Authors: Liang Zhihui , Assembaiuly Yerlan , Akbayeva Sholpan
Published: August 2022

College education has also widely adopted new media technology, which has changed the previous single teaching method and enriched the teaching content. Art education plays an important role in higher education and is an indispensable part of our country’s quality education. The content, methods, and concepts of art education in colleges and universities are also changing with the advent of the new media era. New courses such as multimedia technology, network animation technology, and network advertising design have been added to the teaching curriculum system of colleges and universities for stimulating students’ interest in learning. The online network platform represented by WeChat has had a profound impact in the field of art education. Based on the technical characteristics of art works, this paper briefly classifies the characteristics of art works; the works perform the extraction of local data (picture elements); secondly, the texture feature parameters of each picture element are extracted by using the image histogram processing technology and the gray level co-occurrence matrix statistical analysis method; finally, a relatively mature machine learning model, BP, is introduced. The neural network algorithm learns the technical style characteristics of each part of the ink and wash work, so that on the whole, it can initially achieve the artistic style learning of the entire ink and wash painting.
Prognostic Signature and Therapeutic Value Based on Membrane Lipid Biosynthesis-Related Genes in Breast Cancer
Authors: Xu Yingkun , Jin Yudi , Gao Shun , Wang Yuan , Qu Chi , Wu Yinan , Ding Nan , Dai Yuran , Jiang Linshan , Liu Shengchun
Published: August 2022

There is a need to improve diagnostic and therapeutic approaches to enhance the prognosis of breast cancer, the most common malignancy worldwide. Membrane lipid biosynthesis is a hot biological pathway in current cancer research. It is unclear whether membrane lipid biosynthesis is involved in the prognosis of BRCA. With LASSO regression, a 14-gene prediction model was constructed using data from the TCGA-BRCA cohort. The prediction model includes GPAA1, PIGF, ST3GAL1, ST6GALNAC4, PLPP2, ELOVL1, HACD1, SGPP1, PRKD2, VAPB, CERS2, SGMS2, ALDH3B2, and HACD3. BRCA patients from the TCGA-BRCA cohort were divided into two risk subgroups based on the model. Kaplan–Meier survival curves showed that patients with lower risk scores had significantly improved overall survival (

P
=
2.49
e
−
09

). In addition, risk score, age, stage, and TNM classification were used to predict mortality in BRCA patients. In addition, the 14 genes in the risk model were analyzed for gene variation, methylation level, drug sensitivity, and immune cell infiltration, and the miRNA-mRNA network was constructed. Afterward, the THPA website then analyzed the protein expression of 14 of these risk model genes in normal and pathological BRCA tissues. In conclusion, the membrane lipid biosynthesis-related risk model and nomogram can be used to predict BRCA clinical prognosis.
TILRR Aggravates Sepsis-Induced Acute Lung Injury by Suppressing the PI3K/Akt Pathway
Authors: Wang Xiaoyu , Lin Feixue , Guo Lisha
Published: August 2022

Acute lung injury (ALI) is a life-threatening lung change, and 40% of ALI cases result from sepsis. However, the effective treatment for sepsis-induced ALI is limited. It is urgent to explore novel therapeutic targets for ALI caused by sepsis. Anti-inflammatory therapy is a potential effective treatment for sepsis-induced ALI. Toll-like/Interleukin-1 receptor regulator (TILRR) could trigger aberrant inflammatory responses. Nevertheless, the role of TILRR in sepsis-induced ALI remains unknown. Besides, the phosphatidylinositol 3′kinase/protein kinase B (PI3K/Akt) pathway exerts protective effect on sepsis-induced ALI. Thus, the primary aim of the current study was to investigate whether TILRR contributed to sepsis-induced ALI by the PI3K/Akt pathway. To construct the sepsis-induced ALI model, human pulmonary microvascular endothelial cells (HPMVECs) were treated with lipopolysaccharide (LPS). Besides, the mRNA levels and protein levels were determined by quantitative reverse transcription-PCR (qPCR) and Western blot (WB), respectively. Moreover, cell proliferation was identified by the Cell Counting Kit-8 (CCK-8) assay and Annexin V was utilized to detect apoptosis. Furthermore, levels of proinflammatory cytokines and oxidative stress were tested by the enzyme-linked immunosorbent assay (ELISA) while reactive oxygen species (ROS) was determined by the flow cytometer. Results indicated that TILRR was upregulated to suppress the proliferation and induce apoptosis of HPMVECs under LPS treatment. Besides, TILRR induced aberrant inflammatory responses and oxidative stress in HPMVECs under LPS treatment. Mechanistically, TILRR regulated proliferation, apoptosis, inflammatory responses, and oxidative stress in LPS-treated HPMVECs through inactivating the PI3K/Akt pathway. In summary, TILRR aggravated sepsis-induced ALI by suppressing the PI3K/Akt pathway. These results could provide novel therapy targets for sepsis-induced ALI.
A Case Report of Severe Coagulopathy in Antenatal COVID-19
Authors: Sand Anna , Chaireti Roza , Sennström Maria , Pettersson Karin , Magnusson Maria
Published: August 2022

Pregnancy is a naturally occurring hypercoagulable state, and COVID-19 can cause profound changes in the coagulation system associated with thromboinflammation. We report a case of a pregnant woman with moderate symptoms of COVID-19 and a severe coagulopathy with unexpected low levels of fibrinogen and factor VIII as well as atypical thrombelastometry results. She developed a severe placental dysfunction with intrauterine fetal distress and perinatal death. The case did not fulfil the criteria for preeclampsia or sepsis, and the adverse outcome was assessed as a direct effect of the COVID-19 infection with placental insufficiency, despite absence of serious maternal pulmonary symptoms. Atypical persistent coagulopathy may serve as an important marker of a serious obstetrical situation in COVID-19.
Evaluation of Psychological Distress, Self-Care, and Medication Adherence in Association with Hypertension Control
Authors: Eghbali Maryam , Akbari Maedeh , Seify Kimiya , Fakhrolmobasheri Mohammad , Heidarpour Maryam , Roohafza Hamidreza , Afzali Maryam , Mostafavi-esfahani Fateme-sadat , Karimian Parisa , Sepehr Anis , Shafie Davood , Khosravi Alireza
Published: August 2022

Background. Most of the patients with hypertension (HTN) who undergo medical therapy unaccompanied by psychological and behavioral interventions may not achieve their goal in HTN treatment. Self-care is a key factor in controlling HTN. Given that depression, stress, and anxiety are the most psychological disorders in chronic illnesses. Their impact on self-care, quality of life, and HTN control must be studied more. Methods. We analyzed the difference in medication adherence in 252 patients with low vs. high psychological distress. Also, patients with controlled and uncontrolled HTN were compared according to their psychological distress scores. We further assessed the relation of psychological distress, self-care, and medication adherence with patients’ demographic characteristics. Results. 61.3% of our participants were female with a mean age of 60.6 ± 11.35 and male participants had a mean age of 60.5 ± 11.55. The psychological distress score was significantly higher in women with uncontrolled HTN (pvalue = 0.044). Also, individuals with controlled HTN tend to have a higher medication adherence score (pvalue = 0.01) and higher self-care score (pvalue = 0.033). Hypertensive females had a higher psychological distress score (3.35 ± 2.05) and a lower self-care score (64.05 ± 8.16). There was a positive relationship between age and drug adherence. The self-care score was higher (65.95 ± 7.88) in patients having lower psychological distress levels. Conclusion. A lower psychological distress score can result in better self-care, enhancing the probability of better HTN control; thus, psychological interventions may be necessary for the treatment of HTN. However, more studies are needed to assess the effectiveness of this intervention.
Analysis of College Course Scheduling Problem Based on Ant Colony Algorithm
Authors: Ge Ruqun , Chen Jingyi
Published: August 2022

Ant colony algorithm is a new evolutionary algorithm, which is gradually applied due to its easy robustness with other methods and excellent distributed computing mechanism. Currently, the application field of ant colony algorithm has been infiltrated by a single TSP problem. Ant colony algorithm moves the algorithm toward the optimal solution through the combination of positive feedback and negative feedback. This paper briefly analyzes the basic characteristics of the basic idea and principle of the ant colony algorithm to apply it to the ant colony problem. Abstract the course scheduling problem, transform the course arrangement problem into the maximum matching problem of solving the bipartite diagram, and discharge the high-quality curriculum that basically meet the needs.
Pertinence of Textile‐Based Energy Harvesting System for Biomedical Applications
Authors: Iyer Shriya V. , George Jyothis , Sathiyamoorthy Suhasini , Palanisamy Rohini , Majumdar Abhijit , Veluswamy Pandiyarasan
Published: August 2022

In the era of technological advancements in healthcare and medicine, monitoring of health status and treatment conditions has been made convenient by the development of various categories and forms of biomedical sensors. They have been incorporated within watches and mobile phones and can be worn as stand‐alone based on user preference. However, the longevity, cost, and sustainable functionality have impeded its adoption within the population. In this review article, we have introduced a concept of bridging the textile industry and biomedical sensors to yield a self‐powered biomedical system that operates on textile‐based energy harvesters. Textile‐based wearable systems have been compared to E‐skin‐based systems. The energy released by different actions in human motion has been quantified along with insights on its effective utilization in the form of energy harvesters in the subsequent sections. Information on designing such a textile‐based system with schematics has been done. This review focuses on the development and connection of textile‐based energy harvesters to existing models of biomedical sensors.
Determination of an Energy Source Term for Fractional Diffusion Equation
Authors: Ould Ahmed Mahmoud Sid Ahmed , Ould Sidi Hamed , Ould Sidi Maawiya
Published: August 2022

In this article, we will determine the source term of the fractional diffusion equation (FDE). Our contribution to this work is the generalization of the common inverse diffusion equation issues and the inverse diffusion equation problems for fractional diffusion equations with energy source and using Caputo fractional derivatives in time and space. The problem is reformulated in a least-squares framework, which leads to a nonconvex minimization problem, which is solved using a Tikhonov regularization. By considering the direct problem with an implicit finite difference scheme (IFDS), the numerical inversions are performed for the source term in several approximate spaces. The inversion algorithm (IA) uniqueness is obtained. Furthermore, the effect of fractional order and regularization parameter on the inversion algorithm is carried out and shows that the inversion algorithm is effective. The order of fractional derivatives expresses the global property of the direct problem and also shows the badly posed nature of the inverted problem in question.
Contribution of Superabsorbent Polymers to Growth and Yield of African Leafy Vegetables
Authors: Ndunge Benard Dorcas , Obiero J. P. O. , Mbuge D. O.
Published: August 2022

Superabsorbent polymers (SAPs) have been used as water-saving materials for limited irrigation water resources in arid and semi-arid areas. The purpose of this study was to optimize SAP application dosage and irrigation intervals on the growth of African leafy vegetables (ALVs) under greenhouse conditions. A factorial experiment was conducted under greenhouse conditions to determine the optimal SAP application, dosage, and irrigation intervals for the growth and production of African leafy vegetables. Two species of African leafy vegetables were studied: cowpea (Vigna unguiculata) and African nightshade (Solanum scabrum). The experiment was performed in a randomized complete block design comprising 25 treatments: a factorial combination of five superabsorbent polymer application doses (0 g, 0.5 g, 1 g, 1.5 g, and 2 g) SAP/Kg of soil substrate and five irrigation intervals (3 days, 4 days, 5 days, 6 days, and 7 days) with three replications. Statistical analysis of the results showed that the use of SAP in irrigation can significantly promote the growth and yield of African leafy vegetables. SAP, irrigation, and their interactions significantly affected (

P
<
0.005

) the plant height, stem diameter, leaf area, number of mature leaves/plant, and dry weight of leafy vegetables. Treatment with SAP showed higher growth parameters and yield of vegetables compared to the treatments. Treatment with 1 g SAP/kg of soil substrate and 5-day irrigation interval recorded the highest plant growth and yield, with 24%, 11.7%, 11.1%, and 85.9% increase in cowpea plant height, leaf area, number of mature leaves, and dry weight/plant, respectively. The treatment with 1 g SAP/kg of soil substrate and 5-day irrigation interval was observed as the best for the optimal production of African leafy vegetables under greenhouse conditions. Hence, SAP could be a good strategy for food production within arid and semi-arid lands where water resources are scarce.
Quantitative Analysis of Berberidis Cortex via Quantitative Analysis of Multicomponents by Single Marker (QAMS) Combined with Fingerprint and Chemometrics Methods
Authors: Su Yuting , Peng Yao , Ren Jie , Wu Shangjie , Lei Si , Peng Fei , Sun Zhina , He Xiuqing , Li Juan , Li Shunxiang
Published: August 2022

Berberidis Cortex is rich in alkaloids, and many of them have antibacterial, anti-inflammatory, and hypoglycemic activities. However, few research studies have focused on the quantitative analysis of multiple components from Berberidis Cortex. In this study, a new quality evaluation strategy for Berberidis Cortex was developed and validated by high-performance liquid chromatography (HPLC), which involved single marker, fingerprint, and stoichiometric methods. Using berberine hydrochloride as an internal reference, the relative correction factors of palmatine hydrochloride, magnoline, and jatrorrhizine hydrochloride were 2.4537, 0.9783, and 1.0035, respectively, and their durabilities were also well performed. In addition, both methods mentioned above were used to compare the mass fractions of four isoquinoline alkaloids in ten batches of Berberidis Cortex from different origins. These results indicated that the approach applied in this study was accurate and feasible. The fingerprints of these ten batches of Berberidis Cortex were established, and eleven components were identified with the similarity greater than 0.993. Both cluster and principal component analysis were carried out based on the peak area of these components, the results demonstrated that these ten batches of Berberidis Cortex were divided into two groups and the distribution of the medicinal material was basically consistent. Therefore, quantitative analysis of multicomponents by single marker (QAMS) can be widely used in the quality control of Berberidis Cortex as theoretical basis.
Analysis of the Relationship between Nutritional Status and Bone Age and Sexual Development in Children and Adolescents
Authors: Sun Hong , Wang Weiqun , Zhang Shouyuan , Lin Chenglei
Published: August 2022

Purpose. To observe the correlation between nutritional status, bone age, and sexual development in children and adolescents. Methods. 895 children and adolescents who underwent physical examination in the growth and development clinic and height clinic of our hospital from 2019 to 2021 were selected as the research objects. The subjects were divided into emaciation group, normal group, overweight group, and obesity group. The bone age level, bone age assessment, sexual development, and early maturity rate of each group were compared. Results. The bone age difference (BAD) of the overweight and obesity groups was higher than that of the normal group, and the BAD of the obesity group was higher than that of the emaciation group (

P
<
0.05

). Compared with the normal group, the risk of advancement of bone age in the overweight group increased by 2.674 times (male) and 1.908 times (female), the risk of advancement of bone age in the obesity group increased by 6.376 times (male) and 14.687 times (female), the risk of retardation of bone age in the emaciation group increased by 2.150 times (male) and 3.092 times (female). Whether it was male or female, the sexual development of overweight and obese was higher than that of the normal weight group in the same age group. Among female children, the sexual precocious puberty rate of the overweight + obesity group is higher. Conclusion. The nutritional status of children and adolescents is closely related to their bone age and sexual development.
Mechanical Vibration Test Based on the Wireless Vibration Monitoring System
Authors: Niu Ruibin
Published: August 2022

In order to apply wireless sensor networks to mechanical vibration monitoring, the author proposes a wireless network topology with multiple data collection points for mechanical vibration monitoring. This structure reduces the transmission load of the data collection point, increases the data transmission rate of the network, balances the energy dissipation in the network, and utilizes the general wireless sensor network hardware platform. The network transmission protocol and related auxiliary mechanisms are designed and implemented, and a wireless vibration monitoring test platform is constructed. The transmission performance of the network structure with multiple data collection points is evaluated through the actual test. The experimental results show that by using the wireless sensor network topology with multiple data collection points, it can meet the requirements of continuous transmission of vibration data obtained by 1 kHz sampling. Conclusion. The system performance of the wireless sensor network based on this network structure has been improved under the condition of general hardware, and the network structure of multiple data collection points shows good performance in the process of high-speed data transmission.
Emergency Management System for Coal Mine Safety Based on IoT Technology
Authors: Fang Bo
Published: August 2022

The Internet of Things (IoT) has brought technological innovation to various industries, and it has also brought great impact to coal industry. It is important to study the safety supervision system of coal in the IoT mode to improve effectiveness of safety supervision and make suggestions to improve safety production in coal. In this paper, based on analysis of influence factors and emergency supervision system in the IoT mode, system dynamics modeling theory and method are used to construct a system dynamics model of influence factors and emergency supervision in the IoT mode. The validity and reliability of the model are verified by the system dynamics software to reach more than 98.6%, and the support for the development of coal Internet of things is appropriately increased to support the development of coal Internet of things, ensure the healthy and long-term development of coal Internet of things, improve the level of supervision, and ensure the safe production of coal
Deep Learning-Based Nonstationary Channel Prediction in Tactical Vehicle-to-Vehicle Communication Environments
Authors: Lin Xin , Liu Aijun , Han Chen , Liang Xiaohu , Wang Wenyu , Li Enyu
Published: August 2022

In this paper, we focus on the vehicle-to-vehicle dynamic channel in tactical communication environments, which shows time-varying and nonstationary characteristics due to the fast mobility, directional antennas, and harsh terrain. These situations present great challenges for the channel state information (CSI) acquisition. To obtain an accurate CSI and reduce pilot overhead, we propose a CSI predictor based on the long short-term memory (LSTM) network. As an improved recurrent neural network (RNN), LSTM units have an excellent learning result on both long- and short-term inputs by adding the gating mechanism. Using the outdated sampling CSI sequence as input data of LSTM units enables the predictor to extract complex data characteristics and capture the temporal law of the nonstationary channel. Simulation results are demonstrated to verify that the LSTM-based predictor has better performance than conventional algorithms in IEEE 802.11p standard. Additionally, the key factors that affect the performance of the proposed predictor are further analyzed.
Alpha-Ketoglutarate Alleviates Neuronal Apoptosis Induced by Central Insulin Resistance through Inhibiting S6K1 Phosphorylation after Subarachnoid Hemorrhage
Authors: Ding Peng-Fei , Zhu Qi , Sheng Bin , Yang Heng , Xu Hua-Jie , Tao Tao , Peng Zheng , Chen Xiang-Xin , Li Xiao-Jian , Zhou Yan , Zhang Hua-Sheng , Gao Yong-Yue , Zhuang Zong , Hang Chun-Hua , Li Wei
Published: August 2022

Neuronal apoptosis after subarachnoid hemorrhage (SAH) is believed to play an important role in early brain injury after SAH. The energy metabolism of neuron is closely related to its survival. The transient hyperglycemia caused by insulin resistance (IR) after SAH seriously affects the prognosis of patients. However, the specific mechanisms of IR after SAH are still not clear. Studies have shown that α-KG takes part in the regulation of IR and cell apoptosis. In this study, we aim to investigate whether α-KG can reduce IR after SAH, improve the disorder of neuronal glucose metabolism, alleviate neuronal apoptosis, and ultimately play a neuroprotective role in SAH-induced EBI. We first measured α-KG levels in the cerebrospinal fluid (CSF) of patients with SAH. Then, we established a SAH model through hemoglobin (Hb) stimulation with HT22 cells for further mechanism research. Furthermore, an in vivo SAH model in mice was established by endovascular perforation. Our results showed that α-KG levels in CSF significantly increased in SAH patients and could be used as a potential prognostic biomarker. In in vitro model of SAH, we found that α-KG not only inhibited IR-induced reduction of glucose uptake in neurons after SAH but also alleviated SAH-induced neuronal apoptosis. Mechanistically, we found that α-KG inhibits neuronal IR by inhibiting S6K1 activation after SAH. Moreover, neuronal apoptosis significantly increased when glucose uptake was reduced. Furthermore, our results demonstrated that α-KG could also alleviate neuronal apoptosis in vivo SAH model. In conclusion, our study suggests that α-KG alleviates apoptosis by inhibiting IR induced by S6K1 activation after SAH.
Capacity Optimization of MISO System in Intercell Interference of Visible Light Communication System
Authors: Ali Agha Yasir , Abdelgader Abdeldime M. S. , Farhi Lubna , Laila Umm E. , Wang Shujun
Published: August 2022

The capacity of multiple input and single out (MISO) system is investigated in intercell interference environment of a visible light communication (VLC) system. The interference is dominating in cell edges and the center of the room due to overlapping of light signals from neighbor cell. The footprint of one cell extends at high SNR, and consequently, this increases the intercell interference regions. Therefore, the channel capacity is greatly deteriorated due to interference power. In this paper, the channel capacity can be improved using diversity gain of MISO-based VLC system. The light-emitting diode (LEDs) of MISO system in a cell can use the same data to improve the diversity gain of the system. The MISO array is derived as per SNR requirements in interference region of the room. The capacity of the MISO system is examined and compared with that of the single input and single output (SISO). A trade-off of the MISO array is obtained at different SNRs to achieve the interference free capacity system. Theoretical and simulation capacity response show that the interference is considerably minimized by using diversity gain of MISO system. The interference free capacity is achieved at 44 dB, 49.5 dB, and 51.7 dB SNR using 4X1, 9X1 and 16X MISO system, respectively.
Interval Pythagorean Fuzzy Decision Based on GWOWA Operator
∗
Authors: Jun Hu , Junmin Wu , Mengzhe Wang
Published: August 2022

For the multiattribute group decision-making problem in an interval Pythagorean fuzzy environment, the existing experts and scholars have extended the weighted average (WA), ordered weighted average (OWA), generalized ordered weighted average (GOWA), weighted ordered weighted average (WOWA), and other operators to interval fuzzy environment, while the research on the application and promotion of interval Pythagorean fuzzy with generalized weighted ordered weighted average (GWOWA) operator has not been carried out, GWOWA operator not only retains the advantages of WOWA operator but also introduces artificial variables, which increases the ability of decision-makers to control the aggregation of fuzzy information. Therefore, the GWOWA operator model based on interval Pythagorean fuzzy sets is constructed. First, it is proved that interval Pythagorean fuzzy generalized weighted average operator (IVPFGWA) and interval Pythagorean fuzzy generalized ordered weighted average operator (IVPFGOWA) are special cases of IVPFGWOWA operator, and their idempotence, monotonicity, and boundedness are proved; second, a group decision-making method based on interval Pythagorean fuzzy GWOWA operator is presented. Finally, an example is given to illustrate the effectiveness and scientificity of this method. It is found that the interval Pythagorean fuzzy decision-making method of the GWOWA operator alleviates the loss of information in the decision-making process to a great extent. At the same time, with the increase in the value of artificial variables, the gap between the best scheme and other schemes continues to increase, making the decision-making results more obvious, scientific, and accurate.
Association Study between the Sentinel Lymph Node Biopsy and the Clinicopathological Features of Patients with Cervical Cancer
Authors: Niu Gaoli , Ren Yajuan , Zhai Yanhong
Published: August 2022

Objective. The incidence of cervical cancer is increasing year by year, which seriously threatens the health of female patients. This study is aimed at investigating the association of sentinel lymph node biopsy (SLNB) with clinicopathological features in cervical cancer patients. Methods. Patients diagnosed with cervical cancer in our hospital from February 1, 2019, to June 30, 2021, were selected as the research subjects. Statistical analysis was performed on the SLN examination of patients with cervical cancer with different pathological characteristics and the correlation between the positive rate of SLN detection and the pathological characteristics of cervical cancer. Results. A total of 59 patients with cervical cancer were included in this study, the SLNB detection rate was 94.92%, 15 patients had lymph node metastasis, and the metastasis rate was 25.42% confirmed by histopathology. Thirteen of them had SLN metastases, and the other 2 had non-SLN metastases. The sensitivity of SLNB was 86.67%, and the false negative rate was 13.33%. Statistical analysis results showed that there was no significant difference in the positive rate of SLN among cervical cancer patients with different FIGO stages, pathological types, degree of differentiation, depth of invasion, and tumor size. In addition, the results of Pearson’s correlation analysis showed that the positive rate of SLN was not significantly correlated with the FIGO stage, pathological type, degree of differentiation, depth of invasion, and tumor size of cervical cancer. Conclusion. SLNB has a high sensitivity, safety, and feasibility in the diagnosis and evaluation of lymph node metastasis in cervical cancer. There is no significant correlation between SLNB and the clinicopathological features of cervical cancer.
CAR T Cells Contend with Myeloma in the Bone Marrow Microenvironment
Authors: Graham Charlotte E. , Maus Marcela V.
Published: August 2022

In this issue of Blood Cancer Discovery, Dhodapkar and colleagues find that myeloid, dendritic, and endogenous T-cell populations in the bone marrow microenvironment are associated with progression-free survival (PFS) in multiple myeloma patients responding to B-cell maturation antigen–targeted CAR T cells. Immunosuppressive myeloid cells are associated with short PFS, but a diverse T-cell receptor repertoire and more dendritic cells are associated with a longer PFS, suggesting a potential role for epitope spreading.

See related article by Dhodapkar et al., p. 490 (6).
Getting the Most out of Spirometry: A Tool to Guide Dry Powder Inhaler Use
Authors: Hanon Shane , Vanderhelst Eef , Buls Nico , Verbanck Sylvia
Published: August 2022

Background: Dry powder inhaler (DPI) use requires sufficient peak inspiratory flow over the DPI internal resistance (PIFR). Objectives: We examined whether spirometric peak inspiratory flow (PIFspiro) could serve to predict PIFR in patients with obstructive lung disease. Method: Thirty healthy nonsmokers and 140 stable outpatients (70 COPD, 70 asthma) performed spirometry according to the 2019 ERS/ATS spirometry update, yielding PIFspiro. Using a PIFR measurement device with varying orifices, all subjects’ PIFR values were recorded for 5 predefined resistance levels, characterized by 5 orifice cross sections (SR). A test group including all healthy subjects, 30 of the asthma, and 30 of the COPD patients was used to establish the relationship between PIFR and both PIFspiro and SR by multiple regression. A validation group including the remaining 40 asthma and 40 COPD patients, served to verify whether their predicted PIFR value corresponded to the measured PIFR for each resistance level. Results: The asthma (FEV1 = 78 ± 17 [SD] %pred) and COPD (FEV1 = 46 ± 17 [SD] %pred) patients under study had varying airway obstruction. In the test group, PIFR could be predicted by ln[PIFspiro] (p < 0.0001), SR (p < 0.0001), and SR2 (p = 0.006), with an adjusted R2 = 0.71. In the validation group, estimated PIFR did not significantly differ from measured PIFR (p > 0.05 for the 5 resistance levels). Conclusions: We propose a simple method to predict PIFR for a range of common DPI resistances, based on the device characteristics and on the patient’s characteristics reflected in PIFspiro. As such, routine spirometry can serve to estimate a patient’s specific PIFR without the need for additional testing.
DRAGONFLIES DIVERSITY AND LAND COVER CHANGES IN THE BATUBOLONG RIVER, WEST LOMBOK DISTRICT
Authors: Zulhariadi Muhammad , Irawan Raden Dedi , Zulfaeda Aulia , Hidayani Nurul
Published: August 2022

West Lombok District is the second largest district in Lombok Islands. The diversity of dragonflies (Order Odonata) as a bioindicator of environmental quality has not been widely studied in the West Lombok region. This study aimed to determine the species diversity of dragonflies (Order Odonata) found in Batubolong River, West Lombok District and its relation to the occurring land cover changes. This study was carried out by using a descriptive explorative method, where the sampling technique was done by means of line transects. Maps of study and sampling locations as well as land cover changes were made using ArcGIS 10.4.1 software based on primary and secondary data. The results showed that there were 11 species of dragonflies with a Shannon-Wiener diversity index value (H') of 2.212 (medium diversity), a population density index (C) of 0.126 (low dominance), and a species evenness index (E) of 0.923 (high uniformity). Our study also found two rare species of dragonfly in Lombok Island i.e., 3 individuals of Nososticta emphyla (Lieftinck, 1936) with 9% relative abundance and 1 individual of Drepanosticta berlandi (Lieftinck, 1939) with 3% relative abundance. The discovery of D. berlandi in Lombok is the third time after the findings in 1896 and the 19th century. Analysis of satellite data around the sampling area within the period 2013-2020 showed that there has been an increase in land cover of 6,149.29 m2. The increase in land cover changes may have caused the disappearance of several Odonata species in the sampling location.
DEVELOPMENTAL MORPHO-ANATOMY AND GERMINATION OF THE SEEDS OF Pterocarpus indicus f. echinatus Willd. VARIANTS
Authors: Capiltan Kate , Maldia Lerma , Quimado Marilyn , Tinio Crusty , Combalicer Marilyn
Published: August 2022

Previous studies on the embryo structure of legumes species had resulted in the division of the Fabaceae family into two great subfamilies based on embryo axis curvature. Research on seed morphology and anatomy adds to the knowledge of taxonomy, evolution and ecology. This study determined the seed developmental anatomy, pod and seed morphology as well as germination characteristics of the observed variants (T1 - small prickles; T2 - medium prickles; T3 - long prickles) of Pterocarpus indicus Willd. f. echinatus locally known as prickly narra in the Mount Makiling Forest Reserve (MMFR). Based on the anatomy of the root (radicle) and shoot apex, the formation of the leaf primordium in T2 seeds after radicle protrusion was more progressive. It was observed that the germination rate and the percentage were the highest in T2, where the apical dome was welldeveloped. The germination, pod and seed morphological characters as well as seed anatomical characters were proven to be systematically informative by showing significant differences among the variants.
New state records of longhorn beetles (Insecta: Coleoptera: Cerambycidae) from Meghalaya, India
Authors: Vishwanath Duttatray Hegde  , Sarita Yadav  , Prerna Burathoki  , Bhaskar Saikia
Published: August 2022

We report the range extension of 11 species of Cerambycidae fauna into Meghalaya, northeastern India, based on our studies on the unidentified specimens of longhorn beetles deposited in the National Zoological Collection of the Zoological Survey of India, Shillong. These 11 species under 11 genera, nine tribes, and three subfamilies increases the known Cerambycidae diversity in Meghalaya from 81 species to 92 species.
Morphological assessment and partial genome sequencing inferred from matK and rbcL genes of the plant Tacca chantrieri
Authors: P.C. Lalbiaknii  , F. Lalnunmawia  , Vanlalhruaii Ralte  , P.C. Vanlalnunpuia  , Elizabeth Vanlalruati Ngamlai  , Joney Lalnunpuii Pachuau
Published: August 2022

Tacca chantrieri is a monotypic perennial plant belonging to the family Taccaceae. It is listed as an endangered species by different authors. The plant was found in Thorangtlang Wildlife Sanctuary, a protected area in Lunglei District, Mizoram. Although there is a record of its existence from the forests of Mizoram, there are no detailed studies based on morphology, partial or whole genome sequencing. Plant samples collected from Thorangtlang Wildlife Sanctuary were used for morphological assessment and partial genome sequencing of matK and rbcL genes. This study provides information useful in making conservation decisions.
Range extension of lesser-known orchids to the Nilgiris of Tamil Nadu, India
Authors: M. Sulaiman  , K. Kiruthika  , P.B. Harathi
Published: August 2022

The present paper records the extended distribution of orchids, viz., Oberonia chandrasekharanii V.J.Nair, V.S.Ramach. & R.Ansari, Peristylus plantagineus (Lindl.) Lindl., Porpax exilis (Hook.f.) Schuit., Y.P.Ng & H.A.Pedersen, and P. jerdoniana (Wight) Rolfe, to the Nilgiris of Tamil Nadu.
Can the Sri Lankan endemic-endangered fish Labeo fisheri (Teleostei: Cyprinidae) adapt to a new habitat?
Authors: Dinelka Thilakarathne  , Gayan Hirimuthugoda
Published: August 2022

Labeo fisheri is an endemic and endangered freshwater fish of Sri Lanka. Mainly restricted to the upper reaches of the Mahaweli River basin, it has been previously reported living in deep rapids and among large rocks and boulders. An accidental record of a Labeo fisheri specimen from Victoria Reservoir led us to further study this habitat during the period from January to August 2017. This study was carried out to confirm the presence of a population of Labeo fisheri within the Victoria Reservoir and report its new habitat type in deep stagnant waters. We further investigated the food habits by analyzing the gut contents of L. fisheri in the Victoria Reservoir. Seven individuals were recorded from fishermen’s gill net catch in three fish landing sites along Victoria Reservoir, with an average total length of 24.80 ± 4.30 cm, average standard length of 19.70 ± 3.86 cm and average body weight of 197.69 ± 107.12 g. Based on gut content analysis, only phytoplankton, especially diatoms and cyanobacteria, were found in the gut of L. fisheri. This new population is facing the direct threat of fishing. Effective conservation measures are doubtful, since a fishery is well established in the Victoria Reservoir and the fishing gear used is not species-specific. More research is necessary to understand the population dynamics of L. fisheri in the Victoria Reservoir. In order to conserve it at this locality, community-based conservation measures are recommended.
A new population record of the Critically Endangered Dipterocarpus bourdillonii Brandis from the Anamalai Tiger Reserve, India
Authors: Page Navendu , Kasinathan Srinivasan , Bhat Kshama , G. Moorthi  , T. Sundarraj  , Mudappa Divya , T.R. Shankar Raman
Published: August 2022

Dipterocarpus bourdillonii, a Critically Endangered tree species endemic to the Western Ghats, India, has hitherto been reported mainly from the states of Kerala and Karnataka on the western slopes of the mountain range. In Tamil Nadu, this species has been reported to occur in two locations, but no population details have been documented and the species has neither been listed in state floras nor in a recent compendium of plant species. The present study documents the occurrence of a population of the species, with at least 40 individuals, in the Anamalai Tiger Reserve, Tamil Nadu, extends the known upper limit of its altitudinal range to 733 m, and suggests further surveys and in situ conservation efforts.
An unusual morph of Naja naja (Linnaeus, 1758) (Squamata: Serpentes) from Goa, India
Authors: Nitin Sawant  , Singh Amrut , Rane Shubham , Naik Sagar , Gawas Mayur
Published: August 2022

We report first case of melanism in Naja naja from Goa. Identification of snake is done based on meristic data collected from the specimen. Appropriate documentation of these types of individuals will farther our understanding of this phenomenon.
Natural history notes on three bat species
Authors: Dharmendra Khandal  , Ishan Dhar  , Dau Lal Bohra  , Shyamkant S. Talmale
Published: August 2022

Three bat species have long been considered to occur within the state of Rajasthan—the Lesser Mouse-Eared bat Myotis blythii Tomes, 1857, the Large Barbastelle Barbastella darjelingensis Hodgson, in Horsfield, 1855 and the Serotine Bat Eptesicus serotinus pachyomus Tomes, 1857. Rajasthan is considered the type locality for two of these species—Myotis blythii and Eptesicus serotinus pachyomus. Despite targeted surveys, these bats have not been observed in Rajasthan for more than a century and a half. A chronological review of published literature reveals that the bats were never originally claimed to occur in Rajasthan and their inclusion among bats occurring in Rajasthan was a consequence of assumptions perpetuated as facts.
Understanding and Applying Deep Learning
Authors: Lippmann Richard
Published: August 2022

The past 10 years have witnessed an explosion in deep learning neural network model development. The most common perceptual models with vision, speech, and text inputs are not general-purpose AI systems but tools. They automatically extract clues from inputs and compute probabilities of class labels. Successful applications require representative training data, an understanding of the limitations and capabilities of deep learning, and careful attention to a complex development process. The goal of this view is to foster an intuitive understanding of convolutional network deep learning models and how to use them with the goal of engaging a wider creative community. A focus is to make it possible for experts in areas such as health, education, poverty, and agriculture to understand the process of deep learning model development so they can help transition effective solutions to practice.
A Bestseller Among Artillery Handbooks of the 16th Century
Authors: Andresová Klára
Published: August 2022

One of the important artillery manuals of the 15th century is the Feuerwerkbuch. The treatise was one of the first European didactic technical texts, intended for both artillerymen and their employers. After circulating in manuscript copies for over a hundred years, the text was first printed in 1529. By 1619 it had been published thirteen times in total, making it exceptional among military manuals published in Central Europe at that time. The content of the work has been studied by various medievalists and codicologists to date, but they were not usually concerned with later transformations of the publication. The aim of this paper is to characterise the changes in this work between the late Middle Ages and the beginning of the Thirty Years’ War and to trace its publication history and its publication relationship to other educational texts.
Review of the Iranian Parholaspidid mites (Acari: Mesostigmata) with a key to the species
Authors: HAJIZADEH JALIL
Published: August 2022

Six species of Parholaspidid mites were collected from Guilan province in Northern Iran. Gamasholaspis browningi (Bregetova & Koroleva, 1960) is a new record for the Iranian Parholaspidid mite fauna. This paper provides a checklist for Parholaspidid mites species recorded from Iran, with a key for identification of the species.
Two new species and additional records of the genus Geostiba Thomson, 1858 (Coleoptera: Staphylinidae: Aleocharinae) from Turkey
Authors: ÖRGEL SEMİH
Published: August 2022

In this study, two new species are described from Anatolia, Turkey and illustrated: Geostiba (Tropogastrosipalia) yamani sp. n. (Tokat province) and G. (T.) sinananlasi sp. n. (Sivas province). These two new species are compared to closely related species, G. priva Assing and G. solodovnikovi Assing. The distribution of these species is mapped, and an identification key of these species is provided. Additional records for six species are presented.
Correcting What’s True: Testing Competing Claims About Health Misinformation on Social Media
Authors: Vraga Emily K. , Bode Leticia
Published: August 2022

This study expands on existing research about correcting misinformation on social media. Using an experimental design, we explore the effects of three truth signals related to stories shared on social media: whether the person posting the story says it is true, whether the replies to the story say it is true, or whether the story itself is actually true. Our results suggest that individuals should not share misinformation in order to debunk it, as audiences assume sharing is an endorsement. Additionally, while two responses debunking the post do reduce belief in the post’s veracity and argument, this process occurs equally when the story is false (thereby reducing misperceptions) as when it is true (thus reinforcing misperceptions). Our results have implications for individuals interested in correcting health misinformation on social media and for the organizations that support their efforts.
The Experience of Parenting Gifted Children: A Thematic Analysis of Interviews With Parents of Elementary-Age Children
Authors: Peebles Jodi L. , Mendaglio Sal , McCowan Michelle
Published: August 2022

There is a paucity of research on the day-to-day experiences of raising gifted children from the perspective of parents. This qualitative study aimed to delve deeply into the phenomenon by interviewing parents of elementary-age gifted children. We conducted 12 interviews with parents whose children attended gifted schools. The interview transcripts were analyzed using thematic analysis to identify key themes related to the experience of parenting gifted children. Themes identified included the parents’ description of a “child-driven” approach to parenting, experiencing social isolation due to a lack of understanding, and physical and emotional feelings of exhaustion. The findings are particularly important for parents of gifted children, and other professionals who would benefit from a better understanding of the day-to-day experience of raising gifted children.