bluuebunny/crossref_metadata_2025 huggingface dataset:
Meta-Analysis of the Effects of Straw Incorporation on Maize Yield and Water Use Efficiency in China under Different Production Conditions
Authors: Zhang Xuegui , Zhao Zhengxin , Li Yao , Li Fuyang , Sun Yanan , Cai Huanjie
Published: August 2024

Maize plays a crucial role in China’s grain production, with a cultivation area reaching 44.22 million hectares and an annual yield of 289 million tons in 2023. However, the challenge remains on how to further increase maize yield and water use efficiency (WUE) without adding to the environmental burden. To systematically evaluate the impact of straw incorporation under varying production conditions on maize yield and WUE, this study collected experimental data from multiple locations across China. A meta-analysis was conducted to compare the effects of straw incorporation versus no incorporation, and the main influencing factors were identified using correlation analysis and a random forest model. The results indicate that straw incorporation significantly enhances both maize yield and WUE, with the most pronounced improvements observed under conditions of an average growing season temperature of 19–23 °C, soil pH of 6.5–7.5, low initial soil organic matter content, and deep plowing for straw incorporation. Additionally, moderate nitrogen application rates and straw incorporation amounts (9000–15,000 kg·ha−2) also significantly boost maize yield and WUE. Field management practices and meteorological conditions are identified as the primary factors affecting maize yield and WUE under straw incorporation conditions. Therefore, straw incorporation stands out as an effective agricultural practice for achieving high maize yields and efficient resource utilization. The findings of this study provide valuable insights for global food security and the sustainable development of agriculture.
Research Progress on the Physiological Mechanism by Which Selenium Alleviates Heavy Metal Stress in Plants: A Review
Authors: Yuan Zhigang , Cai Shiqi , Yan Chang , Rao Shen , Cheng Shuiyuan , Xu Feng , Liu Xiaomeng
Published: August 2024

Human activities, such as mining, industrialization, industrial waste emissions, and agricultural practices, have caused heavy metals to become widespread and excessively accumulated in soil. The high concentrations of heavy metals in soil can be toxic to plants, severely affecting crop yield and quality. Moreover, these heavy metals can also enter the food chain, affecting animals and humans and leading to various serious illnesses. Selenium (Se) is not only an essential element for animals and humans but is also beneficial for plants, as it promotes their ability to respond actively to biotic and abiotic stresses. The global issue of Se deficiency in diets has made plants the primary source for human Se supplementation. This paper comprehensively reviews the effects of heavy metal stress on plant growth and development, physiological responses of plants to such stress, and the intracellular transport processes of heavy metals within plants. It particularly focuses on the mechanisms by which Se alleviates heavy metal stress in plants. Additionally, the study delves into how Se significantly enhances plant tolerance mechanisms against typical heavy metals, such as cadmium (Cd), lead (Pb), and mercury (Hg). This integrative research not only expands the boundaries of research in the field of plant heavy metal stress and Se application but also provides new perspectives and solutions for understanding and addressing complex environmental heavy metal pollution issues. By integrating these aspects, this paper not only fills existing gaps in the literature but also offers comprehensive scientific basis and strategic recommendations for environmental protection and sustainable agriculture development.
How Long Should Grasses of South American Campos Grasslands Rest for Stockpiling Forage?
Authors: Risso Barbosa Marlon , Durante Martín , Marin Luciana , Cazzuli Fiorella , Ferreira de Quadros Fernando Luiz , Dixon Rob M. , Riet Correa Franklin , Jaurena Martin
Published: August 2024

Stockpiling forage (i.e., deferring grazing) is one way to provide forage for livestock during intervals of low pasture growth, but there are trade-offs as nutrient content declines with increasing forage maturity. Phosphorous (P) concentration, crude protein (CP) content and organic matter digestibility (OMD) were evaluated in two C3 and four C4 grasses native to the South American Campos grasslands. These were: Bromus auleticus (BROAUL) and Nasella neessiana (NASNEE) as C3 grasses and Andropogon lateralis (ANDLAT), Mnesithea selloana (MNESEL), Paspalum dilatatum (PASDIL), and Paspalum notatum (PASNOT) as C4 grasses. The grasses were grown in pots during five stockpiling periods (450, 900, 1350, 1800 and 2250 degree days, approximately 20, 40, 60, 80 and 100 days). As the forage deferment increased, the nutritional value decreased more in C4 than in C3 grasses. Short rest periods (approximately 40 days) are recommended for PASDIL and MNESEL, and medium rest periods (approximately 80 days) for ANDLAT and PASNOT. However, the C3 grasses BROAU and NASNEE maintained high P and CP concentrations and may be the most appropriate option for long rest periods (≥100 days). This information is important to manage different Campos grassland communities for the optimal rest period according to the dominant species.
Study of the Effects of Condensed Tannin Additives on the Health and Growth Performance of Early-Weaned Piglets
Authors: Ma Min , Enomoto Yuriko , Takahashi Tomotsugu , Uchida Kazuyuki , Chambers James K. , Goda Yuki , Yamanaka Daisuke , Takahashi Shin-Ichiro , Kuwahara Masayoshi , Li Junyou
Published: August 2024

Using 0.5% and 1.0% MGM-P, the objective of the present study was to determine a more appropriate additive level for early-weaned piglets as an alternative to the use of antibiotics. Thirty-six weaned piglets were allotted to one of four groups and given a basal diet (NC), with the basal diet containing either 0.5% (LT) or 1.0% (HT) MGM-P or antibiotics (PC). Diarrhea incidence, growth performance, hematology, blood biochemistry, and blood amino acid concentrations were monitored during the experimental period. Three piglets per group with a body weight nearest to the average level were slaughtered after the experiment to assess their organ index. The results showed that no diarrhea was observed either in the treatment groups or in the control group. The 0.5% group showed an upward trend in body weight and average daily gain at all stages. The WBC counts at 21 days of age were higher (p > 0.05) both in the MGM-P addition groups and the LT and HT groups. For some of the plasma amino acids, such as arginine, phenylalanine concentrations were significantly lower (p < 0.05) in the HT group at the end of the trial. The pathological examination of all organs confirmed no differences. Consequently, the 0.5% MGM-P addition level may be suggested as a potential alternative to the use of antibiotic additives. Even with additives as high as 1%, there is no negative effect on ADG and FCR.
The Activity Patterns and Grouping Characteristics of the Remaining Goitered Gazelle (Gazella subgutturosa) in an Isolated Habitat of Western China
Authors: Peng Dezhi , Zhang Zhirong , Chen Junda , Meng Dehuai , Liang Yongliang , Hu Tianhua , Teng Liwei , Liu Zhensheng
Published: August 2024

Wildlife activity patterns, which reveal the daily allocation of time and energy, are crucial for understanding survival pressures, adaptive strategies, and behavioral characteristics in different environments. Among ungulates, grouping behavior is a prevalent adaptive trait that reflects the population structure, mating systems, and life history strategies formed over long-term evolutionary processes. This study aimed to elucidate the daily activity patterns and grouping characteristics of the rare goitered gazelle (Gazella subgutturosa) in the Helan Mountains of western China from 2022 to 2023 using camera trap monitoring. With a total of 3869 camera days of effective trapping, we recorded 442 independent detections of goitered gazelles. The results revealed the following: (1) Goitered gazelle is primarily active during the day, showing an activity pattern similar to crepuscular animals, with two activity peaks occurring after dawn and before dusk. (2) Daily activity patterns showed both seasonal and sex differences. In the warm season, morning activity peaks occurred earlier, and afternoon peaks occurred later compared to the cold season. The overlap in daily activity patterns between females and males in the warm season was lower than that in the cold season, and this trend persisted throughout the year. (3) The number of times different types of groups were observed varied significantly, with single males and single females accounting for a larger proportion of all observed groups. There was no significant difference in group size across seasons, with groups typically consisting of 1–2 individuals. Our study provides detailed insights into the temporal ecology and population structure of goitered gazelles in arid and semi-arid ecosystems. This information will guide the identification of future conservation priorities and the development of management plans for the reserve.
Whole-Genome Resequencing Reveals Signatures of Adaptive Evolution in Acanthopagrus latus and Rhabdosargus sarba
Authors: Yang Jingyu , Cai Zizi , Fang Yan , Shan Binbin , Zhang Ran , Lin Longshan , Li Yuan , Zhang Jing
Published: August 2024

Acanthopagrus latus and Rhabdosargus sarba are economically important marine species along the coast of China, with similar external morphological characteristics and living habits, with wide distribution and strong adaptability. To investigate the molecular mechanisms underlying the adaptive evolution of these two species, we conducted whole-genome resequencing of 10 individuals of both species from the coastal waters of Wuyu Island, Fujian, China, using high-throughput sequencing technology. We obtained SNP, InDel, CNV, and SV variation information and annotated these variations, constructing a genomic variation database for both species. By comparing the resequencing data with reference genomes, we identified 9,829,511 SNP loci in the population of A. latus and 34,051,056 SNP loci in the population of R. sarba. Using whole-genome SNP data, we employed Fst and ROD methods to identify candidate genomic regions under selection. Functional annotation and enrichment analysis using GO and KEGG databases revealed potential adaptive evolution in R. sarba associated with immune response, feeding, growth and development, and locomotion, while A. latus showed potential adaptive evolution associated with immune response, nervous system, growth and development, and metabolism.
From Traditionally Extensive to Sustainably Intensive: A Review on the Path to a Sustainable and Inclusive Beef Farming in Brazil
Authors: Pereira Mariana de A. , Bungenstab Davi J. , Euclides Valeria P. B. , Malafaia Guilherme C. , Biscola Paulo H. N. , Menezes Gilberto R. O. , Abreu Urbano G. P. de , Laura Valdemir A. , Nogueira Ériklis , Mauro Rodiney de A. , da Silva Marta P. , Nicacio Alessandra C. , Almeida Roberto G. de , Gomes Rodrigo da C. , Silva Juliana C. B. , de Souza Vanessa F.
Published: August 2024

Brazil is the second largest beef producer and a leading exporter, contributing to some 3000 t CWE in global markets (27.7% of market share). The sector has experienced substantial development, but yields remain far below potential, and there are growing concerns regarding land use change and greenhouse gas emissions. The need for sustainable technologies, such as sound pasture management and integrated farming systems, is evident, but adoption may be low amongst farmers unable to keep up with technological advances. This article describes the historical developments of Brazilian beef farming towards sustainability and discusses possible socioenvironmental outcomes. We combined an extensive literature review, public data, and our own insights as senior researchers to achieve that. The trajectory shown here evidenced the technological intensification of Brazilian beef farming, with strong support of public policies for decarbonizing agriculture. Nonetheless, the pace of this transition may affect small to medium farmers with limited access to information, technologies, and credit. Our recommendations involve a broad program of technical assistance and training on sustainable technologies, including financial and digital literacy. A novel approach to financing farmers is suggested to support a sustainable and inclusive transition in beef farming in Brazil.
Enzymic Activity, Metabolites, and Hematological Responses in High-Risk Newly Received Calves for “Clinical Health” Reference Intervals
Authors: Carrillo-Muro Octavio , Rodríguez-Cordero Daniel , Hernández-Briano Pedro , Correa-Aguado Paola Isaira , Medina-Flores Carlos Aurelio , Huerta-López Luis Arturo , Rodríguez-Valdez Francisco Javier , Rivera-Villegas Alejandro , Plascencia Alejandro
Published: August 2024

Enzymic activity, metabolites, and hematological responses for reference intervals (RIs) establish ranges of physiological normality, which are useful for diagnosing diseases and physiological alterations. Within the same species, RIs vary according to age, gender, productive and physiological states, and environmental factors including health management and nutrition. RIs have been extensively studied in dairy calves during a critical stage of life (from birth up to first 90 days of age). A critical stage for feedlot calves is their arrival at the feedlot, but no reports determine RIs for different enzymic activity, metabolites, and hematological responses during their initial period at the feedlot. Consequently, a total of 461 high-risk crossbreed beef calves, received on three different dates, were examined upon arrival at the feedlot. Of these, 320 calves (148.3 ± 1.3 kg body weight) whose “clinical health” was evaluated were included in the study. Blood samples were taken upon arrival and on days 14, 28, 42, and 56 to determine the following parameters: enzymic activity, metabolites, electrolytes, white blood cells, platelets, and red blood cells. Enzymic activity, metabolites, and complete blood count were determined by automated analyzers. The freeware Reference Value Advisor Software was used to calculate the non-parametric values of RIs. This study is the first to establish RIs for different enzymic activity, metabolites, and hematological responses in high-risk newly received calves during their initial period at the feedlot. This information will be useful for veterinary clinical practice and research related to the health and welfare of high-risk newly received calves during their initial period at the feedlot.
Dynamic Changes in the Nutrient Digestibility, Rumen Fermentation, Serum Parameters of Perinatal Ewes and Their Relationship with Rumen Microbiota
Authors: Chen Jiaxin , Wang Siwei , Yin Xuejiao , Duan Chunhui , Li Jinhui , Liu Yueqin , Zhang Yingjie
Published: August 2024

Changes in physiological and biochemical parameters are crucial for the reproductive performance and health of perinatal ewes. This study investigated the temporal variations in feed intake, nutrient digestibility, serum parameters, and ruminal fermentation on days 21, 14, and 7 before lambing (Q21, Q14, and Q7) and days 3, 7, and 14 after lambing (H3, H7, and H14). The results showed that dry matter intake (DMI) and glucose (Glu) gradually decreased (p < 0.05) before lambing and increased (p < 0.05) after lambing. The digestibility of dry matter (DMD), crude protein (CPD), and acid detergent fiber (ADFD) increased (p < 0.05) before lambing, then decreased (p < 0.05) on day H3, and then increased (p < 0.05) on day H14. The rumen pH, NH3-N, and triglycerides (TG) gradually increased (p < 0.05) before lambing and were higher (p < 0.05) on day Q7 than after lambing. The concentrations of acetate, butyrate, and total volatile fatty acids (T-VFA) were lower (p < 0.05) on day Q7 than those on days Q21 and Q14, then increased (p < 0.05) after lambing. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) concentrations gradually decreased (p < 0.05) in perinatal ewes. BHBA and NEFA concentrations were lower (p < 0.05) on day Q21 than those from days Q14 to H14. The rumen microbiota compositions were different (p < 0.05) in perinatal ewes, and g_Anaerovibrio, g_Lachnobacterium, and g_Schwartzia were positively correlated (p < 0.05) with DMI, Glu, acetate, propionate, and T-VFA, and negatively correlated (p < 0.05) with LDL-C. g_Bacillus was negatively correlated (p < 0.05) with DMI, Glu, acetate, propionate, butyrate, and T-VFA, but positively correlated (p < 0.05) with rumen pH and LDL-C. In summary, the DMI, nutrient digestibility, rumen fermentation, and serum parameters changed during the perinatal period of ewes, and the changes in DMI, serum glucose, acetate, propionate, and T-VFA were related to the rumen bacteria.
Screening for Genes Related to Meat Production Traits in Duroc × Bama Xiang Crossbred Pigs by Whole Transcriptome Sequencing
Authors: Xu Yupei , Wang Hui , Cheng Feng , Chen Kuirong , Lei Guofeng , Deng Zhongrong , Wu Xiaoxiao , Liu Cong , Si Jinglei , Liang Jing
Published: August 2024

The meat production traits of pigs are influenced by the expression regulation of multiple gene types, including mRNAs, miRNAs, and lncRNAs. To study the differences in meat production traits at the transcriptional level among individuals with different growth rates, the longissimus dorsi samples from eight Duroc × Bama Xiang F2 crossbred pigs with a fast growth rate (high gTroup) or a slow growth rate (low group) were selected to perform whole transcriptome sequencing and ceRNA regulatory network construction. This study first analyzed the differences in physiological and biochemical indicators, muscle histological characteristics, and muscle fiber types. A total of 248 mRNAs, 25 miRNAs, and 432 lncRNAs were identified as differentially expressed by whole transcriptome sequencing. Key genes that may influence meat production traits include MTMR14, PPP1R3A, PYGM, PGAM2, MYH1, and MYH7. The ceRNA regulatory network map showed that ENSSSCG00000042061-ssc-mir-208b-MYH7, ENSSSCG00000042223-ssc-mir-146a-MTMR14, ENSSSCG00000045539-ssc-mir-9-3-MYH1, and ENSSSCG00000047852-ssc-mir-103-1-PPP1R3A may be the key factors affecting meat production traits through their regulatory relationships. This study provides valuable insights into the molecular mechanisms underlying porcine muscle development and can aid in improving meat production traits.
Cooperative but Dependent–Functional Breed Selection in Dogs Influences Human-Directed Gazing in a Difficult Object-Manipulation Task
Authors: Pongrácz Péter , Lugosi Csenge Anna
Published: August 2024

It is still largely unknown to what extent domestication, ancestry, or recent functional selection are responsible for the behavioral differences in whether dogs look back to a human when presented with a difficult task. Here, we tested whether this ubiquitous human-related response of companion dogs would appear differently in subjects that were selected for either cooperative or independent work tasks. We tested N = 71 dogs from 18 cooperative and 18 independent breeds. Subjects learned in a five-trial warming-up phase that they could easily obtain the reward from a container. In trial six, the reward became impossible to take out from the locked container. When the task was easy, both breed groups behaved similarly, and their readiness to approach the container did not differ between the last ‘solvable’ and the subsequent ‘unsolvable’ trial. Task focus, looking at the container, touching the container for the first time, or interacting with the container with a paw or nose did not differ between the breed groups, indicating that their persistence in problem solving was similar. However, in the ‘unsolvable’ trial, cooperative dogs alternated their gaze more often between the container and the humans than the independent dogs did. The frequency of looking back was also higher in cooperative dogs than in the independent breeds. These are the first empirical results that suggest, in a balanced, representative sample of breeds, that the selection for different levels of cooperativity in working dogs could also affect their human-dependent behavior in a generic problem-solving situation.
Genome-Wide Association Analysis Identifies Important Haplotypes and Candidate Gene XKR4 for Body Size Traits in Pekin Ducks
Authors: Yu Jiang-Zhou , Zhou Jun , Yang Fang-Xi , Hao Jin-Ping , Hou Zhuo-Cheng , Zhu Feng
Published: August 2024

Body size is an important growth indicator in ducks and is a primary selection criterion for physical improvement. An excessively rapid growth rate in meat ducks can result in excessive body size, which may hinder subsequent processing and slaughter operations. However, only a few molecular markers related to body size have been studied in meat ducks. In this study, we performed a genome-wide association study (GWAS) to identify candidate genes and QTLs affecting body length (BL), keel bone length (KBL), neck length (NL), and breast width (BrW) in Pekin ducks (Anas platyrhynchos domestica). Our results indicate the significant SNP for NL is located within a pseudogene, whereas the significant SNP for BrW is located in an intergenic region. More importantly, our analysis identified a haplotype that was significantly associated with both BL and KBL. This haplotype, containing 48 single-nucleotide polymorphisms (SNPs), is localized within the XKR4 gene. The identification of this haplotype suggests that XKR4 may be a key candidate gene influencing BL and KBL in Pekin ducks. These findings have important implications for the breeding and genetic improvement of Pekin ducks, and provide valuable insights into the genetic architecture of body size traits in this species.
Limited Emergence of Salmonella enterica Serovar Infantis Variants with Reduced Phage Susceptibility in PhagoVet-Treated Broilers
Authors: Sevilla-Navarro Sandra , Otero Jennifer , López-Pérez Júlia , Torres-Boncompte Jan , Prucha Tiago , De Gussem Maarten , Silva Daniela , Burgan Julia , Catalá-Gregori Pablo , Cortés Pilar , Llagostera Montserrat
Published: August 2024

Salmonella enterica serovar Infantis (S. Infantis) poses a growing issue in the poultry sector, with phage-based products emerging as a safe and effective control measure. This study investigated the emergence of reduced-phage-susceptibility variants (RPSV) of S. Infantis in PhagoVet-treated broilers, given that RPSV could undermine phage treatment efficacy. The bacteriophages in the PhagoVet product were characterized using transmission electron microscopy (TEM), genome sequencing, and infection profiling. Furthermore, two broiler trials were conducted: a challenge group (T1) and a challenge-and-treated group (T2). The S. Infantis infective dose was set at 104 and 106 colony-forming units (CFUs) per animal, with PhagoVet administration at 106 and 108 plaque-forming units (PFUs) per animal, in Trials 1 and 2, respectively. The results revealed that the four PhagoVet bacteriophages belonged to different genera. PhagoVet evidenced broad-spectrum efficacy against 271 strains representing 18 Salmonella serovars. In Trial 1, PhagoVet reduced bacterial counts in feces to nearly undetectable levels by day 42, with no RPSV detected. However, in Trial 2, three and five RPSVs were detected in feces and ceca, respectively. Consequently, PhagoVet demonstrated efficacy against S. Infantis in broilers, and the potential impact of RPSV is deemed unlikely to compromise its efficacy.
The Effect of an Exercise Paddock on Dairy Cow Behavior, Health, and Nutrient Digestion during the Transition from Pregnancy to Lactation
Authors: Cai Amin , Wang Shiwei , Li Pengtao , Descovich Kris , Fu Tong , Lian Hongxia , Gao Tengyun , Phillips Clive J. C.
Published: August 2024

Providing an exercise paddock may improve the behavior and health of cows in their dry period. We compared a control group of cows in a shed with no exercise paddock and an experimental group in the same shed but with access to an exercise paddock. Both groups had ad libitum total mixed ration (TMR) indoors combined with access to a paddock (Group EX). The other group was just offered TMR indoors (Group IN). Total lying time was longer for cows without the exercise paddock (859 min/d) than for those with the paddock (733 min/d) (p = 0.012). Lying bouts were shorter, there were more allogrooming bouts, and drinking time was longer if an exercise paddock was provided. Cows with the paddock spent on average 76 min/d in paddock activity. Non-esterified fatty acids in the blood were increased by providing the exercise paddock. No significant differences in postpartum milk yield and calf weight of dry cows with or without access to exercise paddock were observed. However, crude protein and neutral detergent fiber digestibility were increased by providing the exercise paddock. The results suggest that providing an exercise paddock for cows in their dry period increased activity, including allogrooming, reduced lying, and improved digestibility of some major nutrients in the feed.
Sucuk, Turkish-Style Fermented Sausage: Evaluation of the Effect of Bioprotective Starter Cultures on Its Microbiological, Physicochemical, and Chemical Properties
Authors: Yilmaz Topcam Mahide Muge , Arslan Betul , Soyer Ayla
Published: August 2024

Bio-protection is one of the most popular natural protection methods to control food safety and shelf life. Lactic acid bacteria, especially Lactobacilli strains, are used in the food industry for this purpose due to their probiotic properties and, accordingly, bioprotective properties. We aimed to investigate the role of the bacteriocin-producing lactic acid bacteria Lactobacillus sakei and Pediococcus acidilactici in inducing microbiological, physicochemical, and chemical changes in the Turkish-style fermented sausage sucuk. The effects of protective cultures were compared with those of commercial starter cultures consisting of Pediococcus pentosaceus + Staphylococcus carnosus; a non-cultured group was used as a control. L. sakei inoculation and, to a lower extent, P. acidilactici inoculation resulted in the rapid domination of lactic acid bacteria (LAB) in the environment, whereas commercially used starter cultures and the non-cultured group showed lower counts of LAB. Moreover, L. sakei and P. acidilactici succeeded in inhibiting pathogens including S. aureus, E. coli, and Enterobacteriaceae. The number of enterococci decreased notably in the L. sakei-inoculated sucuk samples; however, an increase was determined in the samples inoculated with P. acidilactici. On the other side, the effect of commercial starter cultures was not sufficient for the inhibition of food-borne pathogens in the sucuk samples. Consequently, the inoculation of protective cultures, particularly of L. sakei, can provide a considerable contribution to improving microbial quality and food safety, retarding lipid oxidation, and increasing proteolytic activities in sucuk without important changes in its sensory properties.
Progress on Numerical Simulation of Gas-Liquid Two-Phase Flow in Self-Priming Pump
Authors: Qian Heng , Zhao Hongbo , Xiang Chun , Duan Zhenhua , Zhang Sanxia , Zhou Peijian
Published: August 2024

The fundamentals of the design and operation of self-priming pumps, as indispensable equipment in industry, have been the focus of research in the field of fluid mechanics. This paper begins with a comprehensive background on self-priming pumps and gas-liquid two-phase flow, and it outlines recent advances in the field. Self-priming pumps within the gas-liquid two-phase flow state and the spatial and temporal evolution of the transient characteristics of self-priming pumps determine the self-priming pump self-absorption performance. Through mastery of the self-absorption mechanism, high-performance self-absorption pump products can be formed to provide theoretical support for the development of products. In current research, numerical simulation has become an important tool for analyzing and predicting the behavior of gas-liquid two-phase flow in self-priming pumps. This paper reviews existing numerical models of gas-liquid two-phase flow and categorizes them. Reviewing these models not only provides us with a comprehensive understanding of the existing research but also offers possible directions for future research. The complexity of gas–liquid interactions and their impact on pump performance is analyzed. Through these detailed discussions, we are able to identify the challenges in the simulation process and summarize what has been achieved. In order to further improve the accuracy and reliability of simulations, this paper introduces the latest simulation techniques and research methodologies, which provide new perspectives for a deeper understanding of gas-liquid two-phase flow. In addition, this paper investigates a variety of factors which affect the operating efficiency of self-priming pumps, including the design parameters, fluid properties, and operating conditions. Comprehensive consideration of these factors is crucial for optimizing pump performance. Finally, this paper summarizes the current research results and identifies the main findings and deficiencies. Based on this, the need to improve the accuracy of numerical simulations and to study the design parameters in depth to improve pump performance is emphasized.
Real-World Emission Characteristics of Diesel Pallet Trucks under Varying Loads: Using the Example of China
Authors: Zhang Ye , Song Yating , Feng Tianshi
Published: August 2024

Diesel pallet trucks, a type of heavy-duty diesel trucks (HDDTs), have historically been a vital component in logistics and transport due to their high payload capacity. However, they also present significant challenges, particularly in terms of emissions which contribute substantially to urban air pollution. Traditional HDDTs emission measurement methods, such as engine bench tests and those used in laboratory settings, often fail to capture real-world emission behaviors accurately. This study specifically examines the real-world emission characteristics of diesel pallet trucks exceeding 30 t under varying loads (unloaded, half loaded, and fully loaded) and different road conditions (urban, suburban, and high-speed). Considering that data quality is the key to the accuracy of the scheme, this research utilized a portable emission measurement system (PEMS) to capture real-time emissions data of carbon dioxide (CO2), carbon monoxide (CO), nitrogen oxides (NOX), and total hydrocarbons (THC). Key findings demonstrate a direct correlation between vehicle load and emission factors, with the emission factors for CO2, CO, and NOX increasing by 39.5%, 105.4%, and 22.7%, respectively, from unloaded to fully loaded states under comprehensive operating conditions. Regression analyses further provide an emission factor prediction model for HDDPTs, underscoring the continuous relationship between speed, load, and emission rates. These findings provide a scientific basis for pollution control strategies for diesel trucks.
Relative Homogenization of Climatic Time Series
Authors: Domonkos Peter
Published: August 2024

Homogenization of the time series of observed climatic data aims to remove non-climatic biases caused by technical changes during the history of the climate observations. The spatial redundancy of climate information helps to recognize station-specific inhomogeneities with statistical methods, but the correct detection and removal of inhomogeneity biases is generally not easy for the combined effects of individual inhomogeneities. In a homogenization procedure, several time series of a given climatic variable observed in one climatic region are usually homogenized together via a large number of spatial comparisons between them. Such procedures are called relative homogenization. A relative homogenization procedure may include one or more homogenization cycles where a cycle includes the steps of time series comparison, inhomogeneity detection and corrections for inhomogeneities, and they may include other steps like the filtering of outlier values or spatial interpolations for infilling data gaps. Relative homogenization methods differ according to the number and content of the individual homogenization cycles, the procedure for the time series comparisons, the statistical inhomogeneity detection method, the way of the inhomogeneity bias removal, among other specifics. Efficient homogenization needs the use of tested statistical methods to be included in partly or fully automated homogenization procedures. Due to the large number and high variety of homogenization experiments fulfilled in the Spanish MULTITEST project (2015–2017), its method comparison test results are still the most informative about the efficiencies of homogenization methods in use. This study presents a brief review of the advances in relative homogenization, recalls some key results of the MULTITEST project, and analyzes some theoretical aspects of successful homogenization.
Evaluation of GNSS-TEC Data-Driven IRI-2016 Model for Electron Density
Authors: Peng Jing , Yuan Yunbin , Liu Yanwen , Zhang Hongxing , Zhang Ting , Wang Yifan , Dai Zelin
Published: August 2024

The ionosphere is one of the important error sources that affect the communication of radio signals. The international reference ionosphere (IRI) model is a commonly used model to describe ionospheric parameters. The driving parameter IG12 of the IRI-2016 model was optimally updated based on GNSS-TEC data from 2015 and 2019. The electron density profiles and NmF2 calculated by the IRI-2016 model (upda-IRI-2016) driven by the updated IG12 value (IG-up) were evaluated for their accuracy using ionosonde observations and COSMIC inversion data. The experiments show that both the electron density profiles and NmF2 calculated by upda-IRI-2016 driven by IG-up show significant optimization effects, compared to the IRI-2016 model driven by IG12. For electron density, the precision improvement (PI) for both MAE and RMSE at the Beijing station exceed 31.2% in January 2015 and 16.0% in January 2019. While the PI of MAE and RMSE at the Wuhan station, which is located at a lower latitude, both exceed 32.5% in January 2015, both exceed 42.1% in January 2019, which is significantly higher than that of the Beijing station. In 2015, the PI of MAE and RMSE compared with COSMIC are both higher than 20%. For NmF2, the PI is greater for low solar activity years and low latitude stations, with the Wuhan station showing a PI of more than 11.7% in January 2019 compared to January 2015. The PI compared to COSMIC was higher than 17.2% in 2015.
Diurnal Variation in Summer Precipitation and the Characteristics of Precipitation Events in the Western Tarim Basin, China
Authors: Li Man , Zhang Zaiyong , Ju Chenxiang , Yao Junqiang
Published: August 2024

The Tarim Basin in the western part of Northwest China (NWC) is the largest inland basin in the world and one of the most arid regions in the middle latitudes. In recent years, heavy precipitation events have occurred frequently in this region, especially in the western Tarim Basin (WTB), due to the climate change. Based on the hourly precipitation data from 2010 to 2022, the diurnal variation in summer precipitation and the characteristics of precipitation events with different durations in WTB have been analyzed. The results mainly show that (1) the diurnal variations in the precipitation amount (PA), precipitation frequency (PF) and precipitation intensity (PI) mainly present a unimodal pattern, but the times of maximum value do not coincide. The peak value of PA and PF appears between 01:00 and 03:00 BJT (Beijing Time), while the valley value appears around 18:00 BJT, yet the peak value of PI appears between 20:00 and 23:00 BJT with no obvious valley value. (2) There are some differences in the diurnal variation characteristics of precipitation among different summer months and different regions. (3) During the past decade, the precipitation structure in WTB has been continuously adjusted, and short-duration- and long-duration-precipitation-dominant periods appear alternately. On the whole, short-duration precipitation has been more frequent in summer, accounting for 70% of the total precipitation events and 40% of the total accumulated precipitation amount. These results can help us to better understand the refined physical characteristics of precipitation events and enhance our understanding of the local climate in the WTB under the background of climate change.
The Efficacy of Body-Weight Supported Treadmill Training and Neurotrophin-Releasing Scaffold in Minimizing Bone Loss Following Spinal Cord Injury
Authors: Weiser Michael , Stoy Lindsay , Lallo Valerie , Balasubramanian Sriram , Singh Anita
Published: August 2024

Spinal cord injury (SCI) can lead to significant bone loss below the level of the lesion increasing the risk of fracture and increased morbidity. Body-weight-supported treadmill training (BWSTT) and transplantation strategies using neurotrophins have been shown to improve motor function after SCI. While rehabilitation training including BWSTT has also been effective in reducing bone loss post-SCI, the effects of transplantation therapies in bone restoration are not fully understood. Furthermore, the effects of a combinational treatment strategy on bone post-SCI also remain unknown. The aim of this study was to determine the effect of a combination therapy including transplantation of scaffold-releasing neurotrophins and BWSTT on the forelimb and hindlimb bones of a T9-T10 contused SCI animals. Humerus and tibia bones were harvested for Micro-CT scanning and a three-point bending test from four animal groups, namely injury, BWSTT (injury with BWSTT), scaffold (injury with scaffold-releasing neurotrophins), and combinational (injury treated with scaffold-releasing neurotrophins and BWSTT). BWSTT and combinational groups reported higher biomechanical properties in the tibial bone (below injury level) and lower biomechanical properties in the humerus bone (above injury level) when compared to the injury and scaffold groups. Studied structural parameters, including the cortical thickness and bone volume/tissue volume (BV/TV) were also higher in the tibia and lower in the humerus bones of BWSTT and combinational groups when compared to the injury and scaffold groups. While no significant differences were observed, this study is the first to report the effects of a combinational treatment strategy on bone loss in contused SCI animals and can help guide future interventions.
Behavioral and Neural Mechanisms Underlying Sensory–Motor Integration
Authors: Bianco Valentina , Borgatti Renato , Berchicci Marika
Published: August 2024

Sensory–motor integration represents a complex process requiring proper orchestration among multiple sources of sensory information to ensure the best task-related motor output [...]
The Relationships of Specific Cognitive Control Abilities with Objective and Subjective Sleep Parameters in Mild Cognitive Impairment: Revealing the Association between Cognitive Planning and Sleep Duration
Authors: Batzikosta Areti , Moraitou Despina , Steiropoulos Paschalis , Papantoniou Georgia , Kougioumtzis Georgios A. , Katsouri Ioanna-Giannoula , Sofologi Maria , Tsolaki Magda
Published: August 2024

This study aimed to examine the associations between specific sleep parameters and specific aspects of cognitive functioning in individuals diagnosed with mild cognitive impairment (MCI), compared with healthy controls (HCs) by using cognitive, subjective, and objective sleep measures. A total of 179 participants were enrolled, all aged ≥ 65 years (mean age = 70.23; SD = 4.74) and with a minimum of six years of education (mean = 12.35; SD = 3.22). The sample included 46 HCs (36 females), 75 individuals with amnestic MCI (aMCI) (51 females), and 58 individuals with non-amnestic MCI (naMCI) (39 females). Inhibition, cognitive flexibility as a combined application of inhibitory control and set shifting or task/rule switching, and planning were examined. The following D-KEFS subtests were administered for their evaluation: Verbal Fluency Test, Color–Word Interference Test, and Tower Test. Self-reported sleep questionnaires (Athens Insomnia Scale, Stop-Bang questionnaire, and Pittsburg Sleep Quality Index) were used for subjective sleep assessments. Actigraphy was used for objective sleep measurements. Mixed-measures ANOVA, MANOVA, and one-way ANOVA, as well as the Scheffe post hoc test, were applied to the data. The results showed that the three groups exhibited statistically significant differences in the Tower Test (total achievement score, total number of administered problems, and total rule violations). As regards objective sleep measurements, the total sleep time (TST) was measured using actigraphy, and indicated that there are significant differences, with the HC group having a significantly higher mean TST compared to the naMCI group. The relationships evaluated in the TST Tower Test were found to be statistically significant. The findings are discussed in the context of potential parameters that can support the connection between sleep duration, measured as TST, and cognitive planning, as measured using the Tower Test.
Study on Vibration and Noise of Railway Steel–Concrete Composite Box Girder Bridge Considering Vehicle–Bridge Coupling Effect
Authors: Si Jinyan , Zhu Li , Ma Weitao , Meng Bowen , Dong Huifeng , Ning Hongyang , Zhao Guanyuan
Published: August 2024

A steel–concrete composite beam bridge fully exploits the mechanical advantages of the concrete structure and steel structure, and has the advantages of a fast construction speed and large stiffness. It is of certain research value to explore the application of this bridge type in the field of railway bridges. However, with the rapid development of domestic high-speed railway construction, the problem of vibration and noise radiation of high-speed railway bridges caused by train loads is becoming more and more serious. A steel–concrete composite beam bridge combines the tensile characteristics of steel and the compressive characteristics of concrete perfectly. At the same time, it also has the characteristics of a steel bridge and concrete bridge in terms of vibration and noise radiation. This feature makes the study of the vibration and noise of the bridge type more complicated. Therefore, in this paper, the characteristics of vibration and noise radiation of a high-speed railway steel–concrete composite box girder bridge are studied in detail from two aspects: the theoretical basis and a numerical simulation. The main results obtained are as follows: Relying on the idea of vehicle–rail–bridge coupling dynamics, a structural dynamics analysis model of a steel–concrete combined girder bridge for a high-speed railroad was established, and numerical program simulation of the vibration of the vehicle–rail–bridge coupling system was carried out based on the parametric design language of ANSYS 18.0 and the language of MATLAB R2021a, and the structural vibration results were analyzed in both the time domain and frequency domain. By using different time-step loading for the vehicle–rail–bridge coupling vibration analysis, the computational efficiency can be effectively improved under the condition of guaranteeing the accuracy of the result analysis within 100 Hz. Based on the power flow equilibrium equation, a statistical energy method of calculating the high-frequency noise radiation is theoretically derived. Based on the theoretical basis of the statistical energy method, the high-frequency noise in the structure is numerically simulated in the VAONE 2021 software, and the average contribution of the concrete roof plate to the three acoustic field points constructed in this paper is as high as 50%, which is of great significance in the study of noise reduction in steel–concrete composite girders.
Ascites and Serum Interleukin-10 Levels as a Prognostic Tool for Ovarian Cancer Outcomes
Authors: Guigue Paul Adrien , Brezinov Yoav , Yasmeen Amber , Mbarik Maroua , Salvador Shannon , Lau Susie , Gotlieb Walter Henri , Brodeur Melica Nourmoussavi
Published: August 2024

Interleukin-10 (IL-10) has been shown to be present at high levels in the ascites of ovarian cancer (OC) patients; however, little is known about its prognostic value. We sought to correlate IL-10 levels in ascites and sera of OC patients with clinicopathologic characteristics and oncologic outcomes. IL-10 levels and clinical data from biobanked ascites and serum samples of OC patients were evaluated. Receiver operating characteristic curves were used to quantify marker performance and identify IL-10-high and IL-10-low groups. Correlations between IL-10 levels and clinicopathologic data were performed. Survival outcomes were calculated, while the factors affecting them were also investigated. A total of 106 patients had ascites samples, of which 44 serum samples were also available. Mean ascites IL-10 levels were significantly higher in patients with serous histology compared to endometrioid histology (p = 0.024). Fold-change in ascites IL-10 during treatment positively correlated with clinical response, as determined by a change in serum cancer antigen (CA)-125 levels (p = 0.0126). Median progression-free survival (PFS) and overall survival (OS) were shorter in patients with high compared with low ascites IL-10 levels (PFS: 18 versus 60 months; p = 0.007, OS: 42 versus 85 months; p = 0.029). A significant positive correlation was seen between ascites and sera IL-10 levels (p = 0.019). In multivariable analyses, a high ascites IL-10 level was associated with a significantly worse prognosis (PFS hazard ratio (HR) = 1.93; p = 0.02). Patients with high ascites levels of IL-10 have worse outcomes, which are likely reflective of the immunosuppressive effect of IL-10. This highlights its potential role as an immunomodulator in the tumor microenvironment, leading to OC immune evasion.
Revamping Non-Small Cell Lung Cancer Treatments in Stages II and III: Preparing Healthcare for Cutting-Edge Immuno-Oncology Regimens
Authors: Bertolaccini Luca , Casiraghi Monica , Bardoni Claudia , Diotti Cristina , Chiari Matteo , Mazzella Antonio , de Marinis Filippo , Spaggiari Lorenzo
Published: August 2024

Non-small cell lung cancer (NSCLC) poses a significant challenge in clinical oncology, necessitating continual refinement of treatment approaches in stages II and III. Recent advancements have highlighted the potential of neoadjuvant therapy in optimising patient outcomes. Biomarker testing guides neoadjuvant therapy decisions, including epidermal growth factor receptor (EGFR) mutation and programmed death-ligand 1 (PD-L1) expression testing. Neoadjuvant therapy aims to improve oncological outcomes by treating micrometastatic disease and assessing tumour response before surgery. Disease-free survival is a surrogate endpoint for overall survival in both neoadjuvant and adjuvant settings. Multidisciplinary collaboration is crucial for individualised treatment planning and optimising patient care. The management of NSCLC requires a comprehensive approach, integrating expertise across disciplines and tailoring treatment strategies to individual patient needs. Neoadjuvant therapy shows promise in improving long-term outcomes, with biomarker testing guiding treatment decisions. Challenges such as defining borderline resectability and differentiating pseudoprogression highlight the need for ongoing research and collaboration.