bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of the genesis of the legislative initiative of the Supreme Court of the Russian Federation on the introduction of the concept of “criminal offense”
Authors: Железняк Игорь Николаевич
Published: April 2022

В статье рассматривается ситуация, представляющая правовую неопределенность в вопросе соответствия задач оперативно-розыскной деятельности правовой категории «уголовный проступок» по предлагаемой Верховным Судом Российской Федерации законодательной инициативе «О внесении изменений в Уголовный кодекс Российской Федерации и Уголовно-процессуальный кодекс Российской Федерации в связи с введением понятия уголовного проступка». Указанная инициатива, по мнению актора, направлена на гуманизацию уголовного законодательства. Верховным Судом Российской Федерации предлагается из числа преступлений небольшой тяжести выделить деяния, за совершение которых закон не предусматривает наказание в виде лишения свободы, и признать их уголовными проступками. Приводится характеристика уголовно-правовых категорий, при этом акцентируется внимание на отсутствии соответствующих инициатив корректировки оперативно-розыскного законодательства. На основе анализа теоретических источников, мнений ученых, норм уголовного и оперативно-розыскного права, ретроспективы вопроса излагается взгляд автора на совершенствование указанных мер.

The article deals with the situation representing legal uncertainty in the issue of compliance of the tasks of operational investigative activity with the legal category “criminal offense” under the legislative initiative proposed by the Supreme Court of the Russian Federation “On amendments to the Criminal Code of the Russian Federation and the Code of Criminal Procedure of the Russian Federation in connection with the introduction of the concept of criminal offense”. This initiative, according to the actor, is aimed at the humanization of criminal legislation. The Supreme Court of the Russian Federation proposes to single out from among the crimes of minor gravity acts for which the law does not provide for punishment in the form of imprisonment, and recognize them as criminal offenses. The characteristics of criminal-legal categories are given, while attention is focused on the lack of appropriate initiatives to adjust operational-investigative legislation. Based on the analysis of theoretical sources, opinions of scientists, norms of criminal and operational-investigative law, a retrospective of the issue, the author's view on the improvement of these measures is presented.
About the prerequisites for the appointment of deprivation of the right to hold certain positions or engage in certain activities as special types of punishment
Authors: Караваева Юлия Станиславовна
Published: April 2022

Лишение права занимать определенную должность или заниматься определенной деятельностью являются специальными видами наказаний, поскольку направлены на ограниченный круг субъектов, обладающих соответствующими статусно-ролевыми признаками. Данные признаки либо являются специальными признаками субъекта как элемента состава преступления, либо позволяют раскрыть механизм совершения конкретного деяния, не имея при этом значения для целей квалификации. И в том, и в другом случае назначение судом наказания, предусмотренного ст. 47 УК РФ, в качестве основного или дополнительного не вызывает возражений, поскольку налицо связь между совершенным деянием и спецификой субъекта. Вместе с тем, анализ теории и судебной практики показывает, что не во всех случаях применения указанной нормы суд устанавливает наличие подобной связи, руководствуясь, в частности, невысокой общественной опасностью совершенного деяния и (или) личности виновного. Связывая наличие такой практики с недостаточно четко выраженной позицией законодателя, автор указывает на необходимость внесения соответствующих изменений в ст. 47 УК РФ, направленных на обеспечение однозначного учета связи между совершенным преступлением и должностью или деятельностью виновного как предпосылке назначения лишения права.

Deprivation of the right to hold a certain position or engage in a certain activity are special types of punishment, since they are aimed at a limited number of subjects with appropriate status and role characteristics. These signs are either special signs of the subject as an element of the corpus delicti, or they allow to reveal the mechanism of committing a specific act, without having significance for the purposes of qualification. In both cases, the appointment by the court of the punishment provided for by art. 47 of the Criminal Code of the Russian Federation, as the main or additional one, does not raise objections, since there is a connection between the committed act and the specifics of the subject. At the same time, the analysis of theory and judicial practice shows that not in all cases of application of the specified norm, the court establishes the existence of such a connection, guided, in particular, by the low public danger of the committed act and (or) the identity of the perpetrator. Linking the existence of such a practice with the insufficiently clearly expressed position of the legislator, the author points out the need to make appropriate amendments to Article 47 of the Criminal Code, aimed at ensuring unambiguous consideration of the connection between the crime committed and the position or activity of the perpetrator as a prerequisite for the appointment of deprivation of the right.
Gastropods Diversity at Siklotok Waterfall and Silangit Waterfall, in Purworejo Regency, Central Java
Authors: Amelia Pergiwa  , Felicia Zahida  , A. Wibowo Nugroho Jati
Published: April 2022

Gastropods are a type of mollusk that can be found easily on mountain peaks up to the sea floors. Mollusk is considered the most successful invertebrates because it distributed a variety of habitats. Among the 80,000 species of Gastropods, about 1500 of which are found in Indonesia and its surroundings. This study aims to determine the level of gastropod diversity and the presence of gastropods at the Siklotok Waterfall and the Silangit Waterfalls at Purworejo, Central Java. Observations were carried out in triplicate between February to April 2018 using the observational research method, where the observation focused on 2 locations with different heights, 347 masl and 268 masl. The results show that the diversity of Gastropods found at Siklotok Waterfall from March to April 2018 found 193 individuals divided into 13 types of 9 orders and 9 families, while at Silangit Waterfall found 66 individuals divided into 4 types 3 orders and 3 families. The next fact is that the difference in environmental conditions such as altitude, temperature, pH and humidity affect the number of gastropods found, where the number of gastropods at Siklotok Waterfall is more than at Silangit Waterfall.
Diversity of Bivalvia in Estuarine of Suramadu Bridge of Surabaya
Authors: Atlanta Viola , Ambarwati Reni , Nova Mujiono
Published: April 2022

The coast of the Suramadu Bridge is one of the important areas that has function as a route for transportation, recreation, as well as a protected area. However, the data of aquatic biota is rarely studied. One of them is bivalves. This research was conducted in February 2021 with the aim to analyze the diversity of bivalves in the Suramadu Coast. Observations and sampling were carried out in 3 transects 5 x 5 m based on different habitats. Five species of bivalves (Mimachlamys sanguinea, Anadara rhomboidalis, Tegillarca granosa, Barbatia trapezina, and Atrina pectinata) from three families (Pectinidae, Arcidae, and Pinnidae) were identified. The results of the community index show the individual distribution pattern and community stability in the medium category, there is a dominant species (Anadara rhomboidalis) but without significant differences in the number of individuals. This shows that the bivalves community is in a state of stress. A. rhomboidalis has the greatest role in the stability of the community, which can be seen from the value of the Important Value Index and the total volume of the shell. Recently, there are only two species that can be used sustainably, namely T. granosa and A. rhomboidalis.
Study of Correlation and Diversity of Gastropods at Mangrove Ecosystem in Payum Beach, Merauke
Authors: Merly Sendy Lely , Sianturi Reny , Nini Alfonsia Lusi
Published: April 2022

This study had two aims, first was to determine the index of diversity, evenness, richness and dominance of gastropods species in the mangrove ecosystem, to assess the important value index of mangroves in the mangrove ecosystem, and the second one to understand the association of gastropods and mangrove in the mangrove ecosystem in Payum Beach, Merauke Regency. This research was conducted in September-October2021. This research using method of transect with a 100 m lenght of transect size. The research location devided into two station that are distinguished by the mangrove ecosystem to see the associated mollusc species. There were 8 species of gastropods that were analyzed including: Terebralia palustris, Terebralia semistriata, Telescopium telescopium, Cassidula angulifera, Cerithidea obstusa, Littorina intermedia, Littorina pallencens, and Littorina scabra. The diversity index (H’) of gastropods is 1,9370 so it is categorized as moderate, meanwhile the richness index (R) is 0,86 and the dominance (C) 0,16 both of these categorized as low, whilst inversely proportional to the evenness index (E) which shows the number 0,93 which means high evenness so that the community is stable. Furthermore, there are 3 types of mangroves namely Bruguirea cylindrica, Lumnitzera racemosa, dan Aegialitis annulata. Nonetheless, the relationship between the abundance of individuals of gastropods and the presence of mangroves at the research sites at station I and station II tended to be weak.
Back Matter
Authors: Pringgenies Delianis
Published: April 2022

Back Matter
6331 SAYILI İŞ SAĞLIĞI VE GÜVENLİĞİ KANUNU SONRASI LİSANSÜSTÜ TEZLERİN DEĞERLENDİRİLMESİ
Authors: KOÇALİ Kaan
Published: April 2022

Amaç: 6331 Sayılı İş Sağlığı ve Güvenliği Kanunu’nun yayınlandığı 2012 yılı ile 2021 yılları arasında Türkiye üniversitelerinde yapılmış olan lisansüstü tez çalışmalarının değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Yükseköğretim Kurulu Ulusal Tez Merkezi Veri Tabanı’nda (tez.yok.gov.tr) yer alan iş sağlığı ve iş güvenliği, iş güvenliği, iş sağlığı ve güvenliği programlarındaki yüksek lisans ve doktora tezlerinin; tez türleri, sayıları, üniversite dağılımları, faaliyet alanları, araştırma modelleri, yazım dilleri, araştırmacı cinsiyetleri, hangi illerde hazırlandığı ve sayfa aralıkları gibi parametreler analiz edilmiştir.Bulgular: İş sağlığı ve güvenliği alanında 1.254 adet (1.231 yüksek lisans ve 23 doktora) tez hazırlanmıştır. Tez çalışmaları; 21 şehirdeki 47 üniversitenin 3 farklı anabilim dalında, 4 çeşit araştırma modeli kullanılarak, 54 ayrı faaliyet alanı içerisinde özellikle inşaat ve sağlık sektöründe yapılmıştır.Sonuç: Türkiye’de İSG alanında yapılan lisansüstü tez çalışmalarının konu bakımından birbiri ile ciddi bir benzeşme içerisinde olduğu görülmekle birlikte, araştırmacıların ve lisansüstü tez danışmanlarının özgünlük, konu ve yöntem bakımından zenginleşme açısından daha fazla çaba göstermeleri gerekmektedir. Alana özgü bilimsel çalışmaların sayı ve niteliğini arttırmak adına doktora programlarının arttırılmasında yarar bulunmaktadır.
PENGARUH LUMPUR PADA PASIR TERHADAP KEKUATAN BETON
Authors: Romadhon Eri Setia
Published: April 2022

Pengaruh Lumpur dalam campuran beton secara fisis akan mengurangi angka slump, sehingga campuran beton sulit dikerjakan akibatnya kekuatan beton menurun. Sedangkan secara kimiawi kadar Lumpur dalam campuran beton akan mengakibatkan reaksi kimia yang terjadi antara air dan partikel semen terganggu, akibatnya kekuatan beton juga menurun. Pada penelitian ini mencoba untuk mengetahui pengaru Lumpur pada pasir terhadap kekuatan beton. Dari penelitian diperoleh hasil : Pengaruh kenaikan kadar Lumpur dalam pasir secara signifikan berpengaruh terhadap penurunan niliai slump, untuk kadar lumpur dalam pasir mencapai 25% prosentase penurunan nilai slump mencapai 72,7% dari 11 cm menjadi 3 cm, suatu angka yang sangat rendah untuk nilai slump. Untuk kuat tekan beton umur 7 hari kenaikan kadar Lumpur dalam pasir secara signifikan berpengaruh terhadap penurunan kuat tekan, untuk kadar Lumpur dalam pasir 5 % sampai 10% prosentase penurunan kuat tekan beton mencapai 63,08% dan 64,23% suatu penurunan yang sangat besar sekali, apalagi untuk kadar Lumpur mencapai 25% prosentase penurunan kuat tekan betonnya mencapai 71,54%. Untuk kuat tekan beton umur 28 hari kenaikan kadar Lumpur dalam pasir secara signifikan berpengaruh terhadap penurunan kuat tekan, untuk kadar Lumpur dalam pasir 5 % sampai 10% prosentase penurunan kuat tekan beton mencapai 36,13% dan 37,39% suatu penurunan yang sangat besar sekali, apalagi untuk kadar Lumpur mencapai 25% prosentase penurunan kuat tekan betonnya mencapai 58,97%
MODEL PERSAMAAN KUAT TARIK BELAH DAN KUAT TEKAN BETON GEOPOLIMER DENGAN BERBAGAI SUHU PERAWATAN
Authors: Isfahani Muhammad Nafhan , Jonbi Jonbi
Published: April 2022

Kualitas beton ditunjukkan dengan seberapa besar nilai kuat tekannya walaupun beton merupakan bahan yang tidak cukup kuat untuk menahan kuat tarik, untuk itu perlu dilakukan penelitian tentang model hubungan kuat tekan beton. dengan kekuatan tarik belah dengan berbagai perlakuan suhu yang belum pernah dilakukan oleh peneliti sebelumnya. Tujuan dari penelitian ini adalah untuk mendapatkan persentase kenaikan kuat tekan, kuat tarik belah dan model matematis (korelasi regresi) perilaku kuat tarik belah pada kuat tekan beton geopolimer dengan perlakuan temperatur ruang, 60°C, 90° C selama 24 jam. Penelitian ini dilakukan secara eksperimental di laboratorium. Hasil penelitian ini diperoleh bahwa rata-rata kenaikan kuat tekan beton dari suhu kamar ke perlakuan suhu 60 adalah: 32,7% dari suhu 60 ke suhu perlakuan 90 adalah 22,5%. Rata-rata kenaikan kuat tarik belah beton dari suhu kamar ke perlakuan suhu 60 adalah 34,4% dari suhu 60 ke suhu perlakuan 90 adalah 4,7%. Model Persamaan kuat tarik dengan kuat tekan beton geopolimer umur 28 hari yang dirawat pada suhu kamar ditunjukkan dengan persamaan fr = 0,708 fc0.5. Perlakuan pada suhu 60° ditunjukkan oleh persamaan fr = 0,808 fc0.5 . Temperatur perlakuan 90° ditunjukkan oleh persamaan.
EVALUASI BIAYA DAN WAKTU DENGAN EARNED VALUE PADA PROYEK GEDUNG SPORTAINMENT TELKOM CORPORATE UNIVERSITY GEGERKALONG BANDUNG
Authors: Sumanang Irvan Riva'i , Rivai Indartono
Published: April 2022

Pada pelaksanaan suatu proyek membutuhkan pengawasan dan pengendalian yang baik untuk dapat berjalan sesuai dengan kualitas yang telah disepakati dalam kontrak baik ketepatan aspek waktu maupun biaya meskipun jarang ditemui dalam suatu proyek yang dapat berjalan sesuai dengan jadwal ataupun biaya yang telah direncanakan.Pengawasan dan pengendalian ini mutlak diperlukan dalam rangka mencapai target keuntungan tanpa mengurangi kualitas yang telah disepakati dalam kontrak maka penelitian ini bertujuan untuk melakukan evaluasi terhadap Schedule Variance dan Cost Variance, evaluasi terhadap Cost Performance Index dan Schedule Performance Index, evaluasi terhadap besarnya Budgeted Estimate To Complete dan Budgeted Estimate At Complete dan evaluasi terhadap lamanya Schedule Estimate To Complete dan Schedule Estimate At Complete pada proyek pembangunan Gedung Sportainment Telkom Corporate University Bandung.Penelitian ini bersifat kualitatif dengan data atau informasi yang digunakan dalam penulisan tugas akhir ini adalah data primer diperoleh dari studi literatur dan data sekunder diantaranya Kurva S rencana dan realisasi, Harga Pekerjaan/ Anggaran dan Biaya yang telah dikeluarkan sebenarnya oleh kontraktor (Biaya Aktual/ ACWP). Metode pengolahan data menggunakan perhitungan sesuai dengan Earned Value Method atau Metode Konsep Nilai Hasil dengan menganalisa penyimpangan, produktifitas kinerja, prakiraan waktu dan biaya akhir penyelesaian proyek.Dari parameter tersebut dilakukan evaluasi terhadap aspek biaya dan waktu selanjutnya dianalisa biaya yang dikeluarkan untuk pembiayaan proyek dan waktu penyelesaian dengan  Metode Earned Value dilakukan menggunakan data pelaporan minggu ke-20 dengan nilai ACWP Rp. 19.314.546.194,00; nilai BCWS Rp.16.916.964.517,00 dan nilai BCWP Rp.19.071.846.495,00. Hasil analisis data diperoleh estimasi nilai akhir diketahui nilai CV negatif dan nilai CPI 0,99<1 dan nilai BEAC proyek sebesar Rp.41.097.395.211,00 maka disimpulkan bahwa biaya proyek lebih besar dari rencana semula senilai Rp.40.580.980.000,00, dan dapat diketahui pula nilai SV positif dan nilai Indeks SPI 1,13 > 1 dapat diketahui bahwa proyek ini dapat diselesaikan dengan waktu lebih cepat dengan SEAC selama 233,14 hari lebih cepat dari durasi rencana selama 245 hari.
PERENCANAAN GEDUNG PARKIR MOBIL TIGA LANTAI DENGAN MENGGUNAKAN STRUKTUR BETON DI AREA DEPO MRT JAKARTA
Authors: Oemar Fatmawati , Dani Feri Panca Rama
Published: April 2022

The Jakarta MRT depot is experiencing increasing development. Currently, the car park area at the Jakarta MRT Depot is not functioning properly due to the lack of available land, so that many four-wheeled vehicles are parked inappropriately. To overcome these problems, it is necessary to build a car parking area at the Jakarta MRT Depot. The plan is to build a parking building with an area of 6,656 m2, a parking angle design of 90°, a reinforced concrete structure consisting of two floors. The beam dimensions are 650 mm x 500 mm, the column dimensions are 500 mm x 500 mm and the plate thickness is 200 mm. The parking building can accommodate as many as 400 four-wheeled vehicles. In planning the car park building, data are used, including the results of ground sondir. Analysis of calculations using the SAP2000 Version20 design and structure application.
Revisiting the EU Legal System: Substantive & Procedural Loyalty for the Judicial Enforcement of the Rule of Law
Authors: Zinonos Panagiotis
Published: April 2022

Aiming to foster reflection on the role of the EU regarding the enforcement of the rule of law, this essay revisits, in a normative fashion, the Union’s legal system with references to recent and established case law and literature. It understands the judicial enforcement of the rule of law as a synonym of effective judicial protection and analyses the pluralistic system of the Union as being overarched by loyalty. It then introduces three specific components of the rule of law related to its judicial enforcement. The first concerns its material aspect: the standards of protection of rights and principles. The contribution opines that the systemic analysis of the Union excludes conflicts of standards. The second component refers to judicial control. It is argued that the related structural obligations of the Member States are enforceable by individual claims grounded on a self-standing right. The last component is organic and relates to the judge. The contribution posits that the national judge is empowered by her European mandate to enforcing the rule of law. While the technique of exceptional circumstances as part of the mechanism of the European arrest warrant confirms this position, cases of constitutional conflicts suggest the procedural deficiency.

EU legal system, rule of law, effective judicial protection, judicial enforcement of the rule of law, multidimensional legal system, substantive loyalty, standards of protection, procedural loyalty, duties of the Member States, individual claims, European mandate of the national judge, judicial cooperation, preliminary ruling, exceptional circumstances, constitutional conflicts
The Mercosur Socio-Labour Declaration: The Development of a Common Regional Framework in the Global South
Authors: Pucheta Mauro
Published: April 2022

The Socio-Labour Declaration is the legal instrument that protects fundamental labour rights within Mercosur and its Member States legal orders. Its 2015 revision enhanced quantitively and qualitatively the rights enshrined therein. Relying upon recent literature on Latin American regional integration, this article considers the complex institutional and legal framework in which the Declaration has been adopted and implemented. It examines how the intergovernmental character of Mercosur has shaped the legal content of the Socio-Labour Declaration. The institutional context of the Declaration requires the active cooperation and intervention of both regional and national actors. This article explores how Mercosur bodies have taken advantage of the flexible institutional framework to implement the Declaration through regional plans and policies. It also analyses the contrasting enforcement roles of the national executive and legislative powers, characterized by their timidity, and the judicial activism that is essential to consider the Declaration as a justiciable instrument. The article concludes that the Socio-Labour Declaration is a crucial instrument in protecting workers’ rights in this trade bloc, and that the 2015 revision introduced substantial improvements that may provide the legal basis for future judgments, and regional and national labour laws reforms.

Mercosur, Socio-Labour Declaration, Argentina, Brazil, Uruguay, Paraguay, Venezuela, Regional Integration, Labour Rights, Regional Trade Blocs, Latin America, Global South
Is Currency Undervaluation a Subsidy: US Law and Practice and the WTO Compatibility
Authors: Wu Chien-Huei , Lo Mao-Wei
Published: April 2022

On 4 February 2020, the Department of Commerce (Commerce) adopted revised Regulations Regarding Benefit and Specificity in Countervailing Duties Proceedings after reviewing solicited comments. Soon after, the Commerce initiated countervailing investigations against Vietnamese passenger vehicle tires and Chinese twist ties, and for the first time imposed preliminary countervailing duties (CVDs) against these two countries based on currency undervaluation. This article considers the revised regulations, two CVD investigations and their WTOcompatibility. We argue that views on whether or not currency undervaluation constitutes a subsidy reflect divergences between the US and other negotiating parties during the Uruguay Round on the definition of a subsidy. Whereas currency undervaluation does confer benefits to producers and exporters, it does not fulfill the criteria of ‘financial contribution’ and specificity as laid down in the Subsidies and Countervailing Measures (SCM) Agreement; thus the CVD decisions of the Commerce are WTO-incompatible.

Currency undervaluation, Countervailing duties, subsidy, specificity, financial contribution
Innovation Incentives in the Pharmaceutical Sector: Rethinking Competition and Public Policy?
Authors: P. Maier-Rigaud Frank , Lauer Robert , Robles Laura
Published: April 2022

The incentives of pharmaceutical companies to innovate and how competition affects these incentives has been topical in recent years: for the general public, as evidenced by a patent race at an unprecedented pace during the ongoing Coronavirus disease 2019 (COVID-19) pandemic; and more specifically for competition authorities, as demonstrated for example by the role innovation played in the assessment of the Bayer/Monsanto (2018), Dow/DuPont (2017), and the Novartis/GSK (2015) mergers. This article contributes to the innovation debate, notably in the pharmaceutical industry, by giving an overview on firm and market-level incentives to carry out research and development (R&D). Understanding these innovation incentives is relevant for a proper competition assessment where the effect of a particular conduct or structural change on these incentives is considered, but also more generally in the context of public policy or regulatory questions. We review the fundamental elements driving innovation incentives and tentatively relate these to the development of new drugs for neurodegenerative diseases (NDD), in particular Parkinson’s disease (PD) and Alzheimer’s disease (AD).

Health Economics, Pharmaceutical Products, Innovation, R&D, Information Asymmetry, Coase Conjecture, Replacement Effect, Patent Race, Neurodegenerative Diseases, Parkinson’s Disease, Alzheimer’s Disease
Prevalence and related potential risk factors of Toxoplasma gondii infection among slaughterhouse workers and animals in Makkah
Authors: Mohamed Khalil , Bukhari Ibrahem , Ansari Sultan , Khayat Abdulwahab , Shiku Ramzy , Brashi Mohammed , Degnah Narjes , Malki Ali , Gafar Mohand , Bakri Mohamed , Abdel-fattah Mohamed
Published: April 2022

Toxoplasma gondii is a protozoan parasite that causes a parasitic disease known as toxoplasmosis. The disease transmits from animals to humans via the eating raw or insufficient cook meat or by contact with raw meat. The main aim of the present study was to define the prevalence and the associated risk factors of the disease in workers and animals in slaughterhouses in Makkah. The study was based on a cross-sectional study in humans and animals including, sheep, goats, cattle, and camels. Data were collected using a short questionnaire. Approximately 108 blood samples were collected from workers included the butchers and the workers and 160 blood samples of the slaughterhouse animals. Serum samples were kept in -80o C till examined by using ELISA IgM and IgG tests. The data analyzed by using SPSS version 25. The result showed that the prevalence in workers was 0.9% and 25% using IgM and IgG, respectively. In animals, all the results were negative using ELISA IgM and IgG tests. The result showed that there was a correlation between chronic infection and contact with a cat (p<0.015). The study focussed on the T. gondii in slaughterhouse workers which found that both acute and chronic toxoplasmosis. The results also showed no infection was registered in different species of animals in both slaughterhouses.
The Role of CYP 450 Isozymes in Drug-Drug Interaction
Authors: Bakhdar Fatmah
Published: April 2022

The main focus of the pharmacokinetic process is hepatic metabolism, which is responsible for biotransformation and elimination of xenobiotics such as drugs. This step depends primarily on the CYP450 system, which plays a role in drug metabolism and changes their therapeutic responses. CYP450 enzyme system includes many notable points such as major families, their functions and also the factors that can alter their activity and cause significant interaction. According to previous studies, the most important factor affecting this enzyme system is the medications that can enhance or inhibit its activity. The aim of this article is to discuss the detailed mechanism of the interaction between CYP450 enzyme and other drugs. This mechanism is very important when prescribing various medications to avoid the problem of drug-drug interaction. We must remember that many drugs undergo metabolism through more than just isozyme interactions or may pass through dual metabolism pathways. Examples of such drugs are anticonvulsants, antidepressant, anti-infectives, immunosuppressant, and cardiovascular drugs.
Detection of Outliers in The Peruvian Fruit Production Time Series Using Arima Models
Authors: Chávez Manuel , Chavez Israel , Torres Eduardo , Atoche Sandro , Palacios Stefano , Ramón Trelles Pozo Luis , Saavedra Navarro Yesenia , Nicolas Aldana Yarleque Cristhian , Mendoza Gustavo , Chuquihuanca Yacsahuanca Nelson
Published: April 2022

The present applied, non-experimental, descriptive and prognostic research; was aimed at detecting outliers in the agricultural production of Mangifera indica (mango), Persea americana (avocado) and Citrus x aurantifolia (lemon) at the national level, was performed by applying an ARIMA Model. To fulfill it purposes, documentary analysis was used at the National Institute of Statistics and Informatics (In Spanish, INEI). The study sample consisted of the mango, avocado and lemon production indices 2000-2020. As a result, the models were obtained arima mango (1,0,0) (2,1,2) (AIC=5448.99, BIC=5473.35 and RMSE=19067.93), arima avocado (0,1,3) (2,1,0) (AIC=4687.05, BIC=4707.91 and RMSE=4114.35) and arima lemon (1,0,1) (0,1,1) (AIC=4484.36, BIC=4501.76 and RMSE=2551.96) with a 12 months period, the diagram of boxes and whiskers was also made with which it was identified that atypical data (Outliers) abound in the periods of greatest production.
A CAD toolset for modeling and synthesis of technosphere safety systems using blockchain technology
Authors: Kupriianov Georgii , Solnitsev Remir
Published: April 2022

How to solve the problem of timely prevention of technological disasters, in example?My solution: An integrated system of technosphere security with the registration of events in theblockchain.Data from vibration sensors, deformation sensors, position and displacement sensors relative to afixed reference point (as well as humidity, gas, fire and burglar alarm sensors, etc.) mustconstantly fall into the public blockchain. Society should always be aware of the status ofsignificant objects, that is, 24/7.The maximum permissible values of the readings of all systems must also be known and remainunchanged, so that it is possible to make decentralized conclusions about the condition ofstructures, the operation of which is associated with risks in the field of technosphere and othersafety.Accordingly, events should be recorded and short videos should also be recorded, the recordingof which is carried out by the operation of motion sensors that record any environmental changenear the protected object.Verification and certification data of measuring instruments should also be included in theblockchain as separate transactions.The information system based on the blockchain, where monitoring data will be delivered in atimely manner, will not only prevent technogenic disasters, it will determine the responsibilitiesof officials and prevent the implementation of corruption scenarios.Earlier in my publications I already suggested using blockchain to register events of anintegrated system of environmental safety and campaigning.The design of integrated technosphere security system with event logging based on the blockchain is a complex task. And then a special CAD/CAE will come to the rescue. Specifically, a suite of CAD tools for modeling and synthesizing a recycling infrastructure for waste management systems and solutions development in order to prevent the global waste catastrophe.Here I propose the concept of such a computer-aided design toolset.
Determinants of renewable and non-renewable energy demand and new trends in Peru
Authors: Gianella Valdiviezo Curipuma Angie , Elizabeth Leon Vera Sarai , Ebert Yanayaco Culquicondor Santos , Saavedra Navarro Yesenia , Nicolas Aldana Yarleque Cristhian , Ramón Trelles Pozo Luis , Chuquihuanca Yacsahuanca Nelson , Mendoza Gustavo
Published: April 2022

Today, sustainable economic development is essential for a country, so it is necessary to act in the planning and efficient use of our resources and to achieve clean and renewable energy. The determinants of renewable and non-renewable energy demand are mainly based on economic growth, financial development and trade. Likewise, the impact of economic growth on energy demand considers that higher energy consumption leads to economic growth. In Peru, promoting energy planning and efficiency actions, as well as the generation and use of renewable energies for economic and energy development to be sustainable in the country. Therefore, this research analyzes the effect of tariffs, GDP and population on the demand for renewable and non-renewable energy in the period 2013 to 2020.
The personal development of teachers and pupils within the context of health and safety in education
Authors: Serafin Cestmir , Depesova Jana
Published: April 2022

This article concerns itself with questions of health and safety within the context of primary education as a prerequisite for the development of pupil competencies in the given area for their future education in the secondary and tertiary systems and also as a prerequisite for their prospects in their future professional lives. The article presents the results of research conducted among primary school teachers in the Olomouc Region and proposes measures aimed at increasing the level and quality of the education in the area of health and safety based on the conclusions of the research.
Design of interfaces for Dyslexia and Dyscalculia Applications
Authors: Ripalda Daniel , Cobos Miguel , Gallar Perez Yamirlis , Piedra Mario
Published: April 2022

In the field of Human-Computer interaction, one of the decisive factors is the graphical interface; especially in applications in which the user has specific conditions that limit its operation and performance. This is the case of the Gabarato application, which facilitates the treatment of children diagnosed with dyslexia and dyscalculia who are cared for by Sinsoluka Center in Ecuador.During the development phase of the application, it was determined that there is a complexity to achieve specific usability interactions such as “ease of use”, “memorability” and “effectiveness”, especially with users who do not have the ability to operate peripherals of the application. computer and who present physical or cognitive difficulties to manipulate a conventional interface.Although in the preliminary studies the methodologies, standards, and protocols were met in the prototype tests; it was evident that the metrics used might not be effective; For this reason, the present work presents a proposal to measure usability interactions in children who present specific conditions; With these results, new versions of interfaces oriented to mobile devices were made.In this work, comparative data are analyzed that establish differences between the usability metrics with conventional users and users who present specific conditions or disabilities; Additionally, a discussion is offered regarding the elements that make up the interfaces and their relationship with usability heuristics and the fundamentals of human perception.
The use of smart glasses in the assembly industry can lead to an increase in the local maximum values of the forehead temperatures.
Authors: Laun Martin , Friemert Daniel , Czech Christian , Hartmann Ulrich
Published: April 2022

Smart glasses are an emerging digital technology designed to assist employees at a variety of industrial workplaces (1,2). This study applied facial thermography to examine the change of the forehead temperature after having worked on an assembly task with smart glasses for 30 min.METHODSTwelve adults (29.0±9.0 yrs) took part in this study. All participants had to complete a complex construction task realized by a toy model consisting of 75 parts. Two different smart glasses (Microsoft HoloLens and MagicLeapOne) and a tablet (Lenovo) were used to provide the subjects with visual instructions. The forehead temperature was measured before and after the assembly task using a thermal camera system (FLIR-ThermaCam-SC3000). The local maximum forehead temperature was determined using the ThermaCAM-RP software. A two-way rmANOVA (α= 0.05) with factors time (tpre and tpost) and medium (Tablet, HoloLens, MagicLeap) was carried out. RESULTSWorking with three media resulted in the following changes of forehead temperatures (mean and SD): Tablet: (34.95±0.52)°C to (34.41±0.81)°C, HoloLens: (34.95±0.45)°C to (34.67±0.58)°C and MagicLeap: (35.02±0.50)°C to (35.53±0.48)°C. The two-way rmANOVA revealed a statistically significant interaction between medium and time at temperature (p<0.01). The effect of medium was significant at tpost (p<0.001). The post-hoc tests showed significant differences at time tpost between MagicLeap and HoloLens (p<0.05) and between MagicLeap and tablet (p < 0.05). The effect of timing was significant for MagicLeap between tpre and tpost (p <0.05).CONCLUSIONOur findings revealed that assembling component models using smart glasses might increase the local maximum forehead temperature of the user. The differences between the smart glasses support the view that any type of smart glasses models must be thoroughly tested before using it for assembly tasks. The influence of data glasses on temperature during prolonged work should be clarified with future studies.REFERENCES(1)Glockner, Jannek, Mahn, Mahn, & Theis, 2014(2) Berkemeier, Werning, Zobel, Ickerott, & Thomas, 2017
The Differences between Eye Control and Touch Games in Children's Learning
Authors: Xiao Lang , Niu Yafeng , Zhou Tianyu , Yang Wenjun
Published: April 2022

This study comparatively analyzed the effects of eye control and touch on the learning outcomes of children's educational games. According to the task completion time and performance, the article analyzes the performance of eye control and touch control on children's educational games through the method of ergonomics experiment. It is found that the performance of girls is generally better than that of boys, and the completion time of girls is shorter than that of boys. There is no obvious difference in ergonomics between the performance of eye control and touch control. The article also compared the results of the ergonomics experiment with the results of the summative test, In the results of the summative test, the improvement of the eye control group is higher than that of the touch group, which shows that the use of eye control in children's educational games is more effective .
SiRobotics – an assistive experimental robot
Authors: Casiddu Niccolò , Burlando Francesco , Porfirione Claudia , Vacanti Annapaola
Published: April 2022

SiRobotics is a European-funded project that involves 17 partners among companies and universities, which worked together to design and develop novel solutions of collaborative assistive ICT robotics with advanced capabilities to support caregivers, users and families in healthcare services, while act-ing with a socially acceptable behavior. The aim of the project is to support weak users in their daily activities, whether they live in home environments or elder care facilities; assessing the progress of their physical and cognitive decline, i.e. cognitive frailty, dementia, mild cognitive impairment, etc., will enable early diagnosis, objective assessment, therapy control and rehabilitation. Si-Robotics system will be used within the context of elder care facilities or home environments, characterized by the presence of frail people requiring gentle and dedicated attention and interaction, assisted by professional and/or in-formal caregivers and medical operators, working with very scheduled and demanding tasks; a first prototype developed in all its physical and interac-tional features is being tested in a simulation with real end users. The paper will describe our design process and the following choices, involving the shape and aesthetics of the robot.
Art-technology: contributions to future intertwining of creative action
Authors: Laurentiz Silvia
Published: April 2022

The main interest of this paper is to present how art can contribute to the process and development of computational algorithms - in particular, for artificial intelligence. The rationale for this work is that we can no longer underestimate technology as a mere instrumental manifestation; much less believe in its supposed neutrality, since technology brings the dominant discourses embedded in it; and a critical posture is necessary to think about future creative actions with the use of technology. This makes the artist and the art fundamental pieces of this puzzle of representational systems, modeling, and creative cognitive procedures. The premise is that understanding these representational systems and their procedures opens a field of possibilities both for the artist's experiences and for the computer scientist in the development of their programs, in intertwining of creative actions.
Correlational Analysis Between Work Absenteeism and Aspects of Human Behavior
Authors: Gabriel Gutiérrez Luis , Alexandra Malagón Torrez María , Alonso Tobón Gaviria Jaime
Published: April 2022

This research aims to determine the relationship between medical absenteeism, sociodemographic characteristics and human behavior in the company Gran Colombia Gold Segovia. For this purpose, a study with a quantitative approach and correlational scope has been developed, based on the database of absenteeism provided by the company and made up of 832 records generated during 2020. A simple randomized sampling was used for the selection of the sample, considering a confidence level of 95% and a margin of error of 5%, resulting in a total of 264 records to be analyzed. To associate the study variables, bivariate tables are considered, making use of statistics according to the parametric behavior. According to the above, it is evidenced that trauma and poisoning correspond to more than 51% of the total causes of absences, which were analyzed in a predominantly male population (90%) aged between 40 and 50 years with low educational level, that is, incomplete primary or secondary school, population who have spent a large part of their working life in activities related to mining and inherited from their parents and siblings.On the other hand, it is considered that absenteeism is significantly related to lifestyle, such as smoking, alcohol consumption, excess body mass index, low physical activity and unhealthy eating habits, aspects that explain a substantial proportion of the absence from work of the personnel working in this company, and also obey to adaptive and self-organized human behaviors, which were learned from generation to generation, as well as the learned processes to the development of the technical skills of the mining labor.
Usability design of concrete grouting equipment
Authors: Xi Yuchen , Chen Xue
Published: April 2022

Concrete grouting equipment is often used in engineering construction in industries such as bridge construction and highway construction, and is an indispensable part of engineering equipment. The current research on concrete grouting equipment is mainly focused on technological breakthroughs and innovations, and there are deficiencies in the usability of equipment. This research aims to study the usability design of concrete grouting equipment. Through the overview of usability, The development status and future trends of concrete grouting equipment ，user interviews summarize the usability design elements of concrete grouting equipment, and optimize the design of concrete grouting equipment.
Smart healthcare service system for elderly based on AIoMT
Authors: Liang Shuang , Zhou Min , Yao Peian , Tosi Francesca
Published: April 2022

In the age of digitalization, digital technologies offer incredible opportunities to the healthcare sector. No matter where elderly people are, they have to interact with various digital devices in the real world. By using digital sensors, smart devices, Internet of Medical Things, big data, cloud/edge computing, Artificial Intelligence and other advanced technologies, the smart system can observe and analyze the lives of the elderly, dynamically access their information and data, connect people, materials and institutions, and then actively manages and responds to their demands in an intelligent manner. The system can promote interaction and cooperation among social institutions and all stakeholders, help organizations and individuals make informed decisions through information sharing, facilitate the rational allocation of resources, and finally ensure that elderly people can get the services they need. The smart system can integrate and coordinate social systems to realize the dynamic and refined management of the elderly.
Developing a software for the affective image tests using eye tracking technology
Authors: Uguña Juan , Pablo Zúñiga Juan , Barrera Andrea , Argudo Andrea , Bermeo Alexandra , Alvarado Cando Omar
Published: April 2022

The development and implementation of software that consists of digitizing a psychological test, in synchronization with the acquisition of eye biosignals is presented. The test uses 32 affective images from the IAPS and OASIS sets, implemented in the PsychoPy software, allowing the establishment of presentation times for visual stimuli, colors, texts, etc. For the calibration and acquisition of data, such as fixation times, first gaze, saccadic movements, and heat maps, the use of Gazepoint Control and Gazepoint Analysis is necessary. The software was validated by a group of psychologists with a population of 3 children, 3 adolescents, and 4 adults, with a duration of 8 minutes. From the pilot test, a survey was conducted among psychologists, obtaining a score of 9.22 out of 10, resulting in the validation of the software.
Layout of Direct Input Interface Based on Virtual Space
Authors: Li Helu , Zhou Xiaozhou
Published: April 2022

Immersive virtual environment has the potential to realize natural interaction in users' close interactive space. To explore the efficient layout of direct input interface suitable for hand-eye cooperation in virtual environment, through the freehand clicking experiment, the participants were required to quickly click the random targets in three different spatial depths. The results show that in the visual field of head mounted display (HMD), the depth has a significant impact on the arm movement time and clicking accuracy. It is suggested that the low-frequency and short-term interactive content can be placed in the left and upper right areas of the visual field, and the high-frequency and long-term content can be placed in the central and lower area with low consumption endurance. The down-right area is not suitable for quick click. This paper proposes an efficient direct input interactive layout in virtual space based on spatial dimensions and arm kinematics.
The interface design of Chinese input keyboard applied to eye movement control system
Authors: Tang Lei , Chen Yunfei , Huang Ziyue , Chen Qian
Published: April 2022

The typing system of eye movement control mainly adopts the layout of QWERTY keyboard, the design of which increases the bimanual alternate operation based on the frequency of letters to relieve fatigue and improve efficiency. Nevertheless, with regard to the eye control operation, such design significantly increases the movement path of the eyes, which in turn hinders the typing efficiency. In view of this, this research firstly makes statistics on the selected Chinese word set and the transition frequency between letters according to Pinyin input method. In an attempt to ensure that users can minimize eye movement while typing, a greedy algorithm is used to generate an irregular letter layout. On the basis of this layout, a new eye-controlled keyboard layout is designed in this research in combination with the principles of interface interaction design and the physiological characteristics of eye movement control. Finally, by virtue of setting the contrasted eye-controlled typing experiment, this research demonstrates that the new eye-controlled keyboard layout presents a certain degree of advantages in input efficiency and relieving user fatigue.
Optimal Design of Operating Interface in Slidform Paver’s Remote Controller
Authors: Huang Ziyue , Chen Yunfei , Tang Lei , Chen Qian
Published: April 2022

The slidform paver’s remote controller enables the operator to move around the machine at any time in a manual control mode, thus making the opera-tor acquire a more ideal paving operation vision. Taking GOMACO G+ re-mote as the research object, this research not only systematically analyzes the structure of human-machine interface in G+ remote from the perspective of ergonomics, but also puts forward the corresponding optimization design scheme based on the operation logic and human habits of HCI theory, so as to realize the optimization design concerning the human-computer interface of the slidform paver’s remote controller. Additionally, the subjective evaluation of experts represented by the evaluation of information readability and communication correctness is adopted to evaluate the efficiency of the operation panel before and after optimization. In accordance with the experimental results, it is indicated that the remote control interface have been optimized to a certain extent.