bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemberdayaan Petani Melalui Inovasi Biochar sebagai Solusi Pengganti Pupuk Kimia di Desa Grenden Kecamatan Puger Kabupaten Jember
Authors: Putri Ditta Kharisma Yolanda , Mumtazah Zuhriah , Jannah Diana Permata Nur Mifdatun , Abdullah Lailatul Krisna
Published: August 2023

Indonesia merupakan negara agraris yang memiliki potensi besar dalam menghasilkan pangan karena lahan tanah pertanian yang luas. Lahan pertanian di Indonesia mengalami degradasi lahan sebagai akibat kurang tepatnya dalam pengelolaan. Biochar merupakan salah satu solusi yang berupa padatan kaya akan karbon terbuat dari bahan organik diproses melalui pembakaran dengan sedikit oksigen. Salah satu bahan baku pembuatan biochar adalah sekam padi. Desa Grenden merupakan desa terbesar di Kecamatan Puger dengan luas wilayah yakni 1.111.690 m2, dimana sebagian wilayahnya masih tergolong tanah sawah aktif. Permasalahan petani di Desa Grenden ini adalah kurangnya ketersediaan subsidi pupuk dan kurangnya sosialisasi dari pihak terkait penggunaan atau pemanfaatan bahan-bahan limbah pasca panen sebagai alternatif pupuk organik. Hal ini yang mendasari untuk melakukan sosialisasi dan pelatihan serta pendampingan tentang bagaimana mengolah limbah sekam padi menjadi biochar. Metode pengabdian yang dilakukan berupa sosialisasi dan pelatihan pengolahan limbah sekam padi menjadi biochar. Sosialisasi dan pelatihan diikuti oleh 20 orang dari kelompok tani. Hasil sosialisasi dan pelatihan biochar dapat diaplikasikan serta dapat memunculkan ide UMKM berupa penjualan biochar bagi warga Desa Grenden.
Pelatihan Peningkatan Kompetensi Guru-Guru SMK Jurusan Keteknik Kimiaan se-Jawa Timur dalam Bidang Unit Operasi Ektraksi
Authors: Qomariyah Lailatul , Zuchrillah Daril Ridho , Altway Saidah , Prajitno Danawati Hari , Surono Agus , Rachmaniah Orchidea , Ramadhitya Irfan , Dhiaulhaq Ahmad Nezard
Published: August 2023

Guru sebagai tenaga pendidik memiliki kompetensi pedagogi dan profesional dalam menjalankan tugasnya, Guru Sekolah Menengah Kejuruan (SMK) jurusan keteknik kimiaan diharapkan dapat mengembangakn strategi pembelajaran untuk meningkatkan kompetensi profesionalnya. Namun banyak guru SMK jurusan keteknik kimiaan memiliki latar belakang pendidikan keguruan atau sains murni, sehingga kompetensi yang dimiliki belum paripurna. Oleh karena itu, tim pengabdian kepada masyarakat yang terdiri dari dosen Departemen Teknik Kimia Industri dan Teknik Kimia, serta tenaga praktisi dari Industri melaksanakan kegiatan berupa pelatihan peningkatan kompetensi guru-guru SMK jurusan Keteknik Kimiaan se-Jawa Timur bidang unit operasi ekstraksi. Kegiatan pelatihan tersebut telah dilaksanakan secara daring pada tanggal 8 September hingga 24 November 2021 menggunakan aplikasi Zoom. Peserta pelatihan mencapai 120 peserta dengan 35 SMK yang terdaftar. Peserta mengalami kenaikan kompetensi setelah mengikuti pelatihan daring dengan pemateri dari tim dosen Departemen Teknik Kimia Industri dan juga membuat laporan praktikum yang telah disedikan. Metode yang digunakan salah satunya adalah tugas aktualisasi berupa membuat video best practice praktikum ekstraksi sederhana dengan bahan yang ada di sekitar lingkungan sekolah masing-masing, terdapat 24 video yang dapat ditonton di Youtube channel Departemen Teknik Kimia Industri ITS.
Desain Fasilitas Parkir Gedung Fakultas Teknik Universitas Katolik Widya Mandira Kupang
Authors: Pedo Krisantus Satrio Wibowo , Mooy Merzy , Usboko Gregorius Paus
Published: August 2023

Masalah perparkiran pada Gedung Fakultas Teknik (FT) Universitas Katolik Widiya Mandira Kupang (UNWIRA) dikarenakan tingginya volume parkir yang tidak sebanding dengan fasilitas parkir yang memadai. Penyelesaian masalah ini adalah dengan melakukan desain fasilitas parkir yang sesuai dengan karateristik parkir pengguna gedung. Data diperoleh dari pengamatan lokasi serta pembagian kuesioner kepada pengguna gedung. Hasil pengamatan pada lokasi menunjukkan bahwa lahan parkir yang tersedia belum dimanfaatkan dengan baik serta fasilitas parkir yang sangat tidak memadai. Hasil pemilihan moda penggunda gedung, sebanyak 73,4% mahasiswa dan 43% dosen/ pegawai menggunakan motor dan sebanyak 1% mahasiswa dan 57% dosen/ pegawai menggunakan mobil. Karateristik parkir pengguna adalah kecenderungan parkir pada tempat teduh dan sedekat mungkin dengan pintu masuk. Rekomendasi yang diberikan adalah adanya penambahan lahan parkir pada sisi kiri dan kanan gedung dan dilengkapi dengan kanopi parkir, jalur sirkulasi serta jalur pedestrian berkanopi. Kapasitas ruang parkir setelah dilakukan desain ulang dapat memenuhi volume parkir yang ada, dengan jumlah SRP motor sebanyak 340 dan SRP mobil sebanyak 40. Penyuluhan hasil desain fasilitas parkir ini direspon dengan baik oleh perwakilan Fakultas Teknik dan Program Studi.
Sosialisasi Instore Drying Sebagai Upaya Penyimpanan Bawang Merah Terkontrol Berbasis Panel Surya di Sukomoro, Nganjuk, Jawa Timur
Authors: Suyatno Suyatno , Indarto Bachtera , Fatimah Iim , Prajitno Gontjang
Published: August 2023

Bawang merah merupakan salah satu komoditas yang keberadaannya selalu menjadi perhatian pemerintah selain padi dan juga cabai. Ironisnya, selain harga pupuk dan benih yang cukup mahal, petani masih harus berhadapan dengan harga jual yang rendah ketika panen raya tiba. Hal ini diakibatkan oleh resiko yang harus dihadapi jika harus disimpan dalam jangka waktu yang lama dan menunggu harga stabil (tinggi). Produk bawang merah bisa menjadi menyusut bahkan busuk. Berdasarkan alasan ini maka langkah yang diambil petani adalah segera menjual meskipun dengan harga rendah. Pengabdian kepada masyarakat ini bertujuan untuk membuat alat penyimpan hasil panen bawang merah yang disebut dengan instore drying. Alat yang didesain dilengkapi dengan sirkulasi udara yang baik sehingga ruang penyimpanan memiliki tempertur dan kelembaban yang cukup agar bawang tidak mudah busuk. Untuk menjaga kondisi tersebut, ruang ini dilengkapi dengan sensor suhu, sensor kelembaban, serta actuator berupa pemanas dan kipas penyedot. Semua sensor dan actuator tersebut dioperasikan menggunakan sumber tegangan dari panel surya serta dapat diatur sesuai dengan kebutuhan. Pelaksanaan pengabdian masyarakat ini dilakukan di Desa Kajang, Kecamatan Sukomoro, Kabupaten Nganjuk. Dari kegiatan ini dihasilkan sebuah alat (ruang) penyimpanan bawanag merah hasil panen baik untuk bibit maupun yang akan dijual dengan kapasitas 500 kg. Melalui alat ini, petani tidak dirugikan karena bawang yang rusak. Sehingga petani tidak mengalami kerugian akibat kerusakan bawang karena proses penyimpanan.
Desain Pengembangan Thermometer dengan Output Audio untuk Siswa Tunanetra SMPLB-A YPAB Surabaya untuk Menunjang Pembelajaran Ilmu Pengetahuan Alam
Authors: Pramata Azzah Dyah , Ardhyananta Hosta , Widyastuti Widyastuti , Felicia Dian Mughni
Published: August 2023

Thermometer merupakan alat praktikum yang fundamental. Namun bagi siswa tunantera di SMPLB-A YPAB, praktikum Bab Kalor pada pelajaran Fisika dilakukan dengan cara yang sangat sederhana tanpa menggunakan Thermometer. Berdasarkan pernyataan dari guru SMA di SMPLB-A YPAB Surabaya, siswa hanya dijemur dibawah terik matahari untuk memperkenalkan kalor atau panas. Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk pengembangan alat peraga Thermometer dengan output audio yang dapat diakses oleh siswa tunanetra guna mendukung pembelajaran konsep fisika dasar bagi siswa tunanetra. Hal ini disebabkan karena keterbatasan fasilitas yang dapat diakses oleh siswa penyandang tunanetra di sekolah tersebut. Kegiatan dimulai dengan penyiapan kegiatan melalui komunikasi awal internal terhadap tim ITS untuk persiapan peralatan, bahan, personel dan jadwal kegiatan. Kegiatan selanjutnya ialah konsolidasi dengan pihak SMPLB-A YPAB untuk melakukan studi mengenai kondisi real di lapangan dan pengumpulan materi dasar terkait sekolah tersebut sebagai tempat dilaksanakannya pengabdian masyarakat. Kegiatan ini diharapkan memberikan masukan mengenai kebutuhan materi dan pengetahuan praktis dari masyarakat. Dengan demikian, pengembangan alat Thermometer dengan output suara diharapkan dapat membuka akses siswa tunanetra untuk menggunakan Thermometer sebagai alat penunjang pemahaman mata pelajaran IPA. Sehingga, kesenjangan pendidikan bagi anak berkebutuhan khusus dapat dikurangi.
Pembangunan Bendungan pada Sistem Pengairan berbasiskan Teknologi Hydram bagi Petani Sayur dan Tambak Ikan di Batu Bersurat Kabupaten Kampar
Authors: Huda Feblil , Rosma Iswadi Hasyim , Jamaan Ahmad , Nazaruddin N , Ginting Yogie Rinaldy
Published: August 2023

Artikel ini menggambarkan kegiatan pembangunan bendungan dalam rangka mewujudkan sistem irigasi berbasiskan pompa hydraulic ram (hydram) untuk petani sayur dan tambak ikan di Kelurahan Batu Bersurat, Kecamatan XIII Koto Kampar, Kabupaten Kampar, Provinsi Riau. Pembangunan bendungan dapat dilaksanakan dengan baik setelah melewati 4 tahap utama, yaitu: pembersihan aliran sungai sebagai sumber air utama pada sistem irigasi berbasis hydram, pembuatan cekungan pada sungai yang berbibir batu cadas, membangun bendungan, dan pemasangan instalasi pipa buangan. Keberhasilan pelaksanaan seluruh tahap tersebut tidak terlepas dari kerjasama yang baik antara Tim Pengabdian Masyarakat Universitas Riau dengan masyarakat selaku mitra petani sayur dan tambak ikan. Akhirnya, berhasilnya pembangunan bendungan ini dalam rangka pembangunan irigasi berbasis hydram perlu disempurnakan dengan mentransfer pengelolaan irigasi tersebut sehingga dapat beroperasi secara berkesinambungan.
Drug Breakdown: Isotretinoin
Authors: Rees Sharon
Published: August 2023

In this column, Sharon Rees aims to refresh knowledge and interest in some of the commonly used drugs in a series of tweets. This month she is talking about #isotretinoin
Rheumatology and prescribing
Authors: Robertson Deborah
Published: August 2023

Deborah Robertson provides an overview of recently published articles that may be of interest to non-medical prescribers. Should you wish to look at any of the papers in more detail, a full reference is provided
Managing side effects of contraception
Authors: Kelsey Sally
Published: August 2023

All contraceptive methods can cause side effects, some of which may be beneficial. Women often discontinue or change their contraception due to recognised or perceived side effects of the method. Good contraceptive counselling should include discussion of side effects, and prepare women for what to expect. Many initial side effects may with lessen with time. Explanation and understanding of this can discourage early discontinuation of methods. The Faculty of Sexual and Reproductive Healthcare offers practical and evidence-based options for management of method side effects. Using proven management strategies, in a partnership with the woman, may increase acceptability of the method and reduce early discontinuation.
Ultrasound's New Depths
Authors: Ford Jason
Published: August 2023

Device scans pregnant manta ray
Microrobots Key to Medical Sensing
Authors: Knight Helen
Published: August 2023

Shape memory alloys can be deformed in response to temperature change
Indian Test Bed for Battery Research
Authors: Nathan Stuart
Published: August 2023

Project will combat heat degredation
High Time for Hydrogennews
Authors: Ford Jason
Published: August 2023

With the cost of renewable energy falling and emissions regulations tightening, the time has never been better for hydrogen to fuel heavy duty trucks
On the Future, a Challenge for Engineers
Authors: Rees Lord
Published: August 2023

Professor Lord Rees Kt OM HonFREng HonFMedSci FRS, Astronomer Royal at the Institute of Astronomy, University of Cambridge
On Track or Off the Rails?
Authors: Wade Andrew
Published: August 2023

Too big to fail or destined for the scrapheap? The UK government’s eventual decision on HS2 will cast a long shadow for years to come
Top Deck
Authors: Ford Jason
Published: August 2023

The Engineer took an in-depth look at the USS Forrestal, a pioneering warship hailed as the world’s first supercarrier
Stairway to Heaven
Authors: Powell Gareth L.
Published: August 2023

From sub-surface freight delivery tubes, to space elevators for ferrying workers to off-planet manufacturing facilities, resident science fiction writer Gareth L. Powell ponders some of the ingenious transit technologies of the future.
Neil Armstrong: Reluctant American Hero
Authors: Smith Nick
Published: August 2023

Destined to be remembered as the first human to walk on the Moon, Apollo 11 commander Neil Armstrong was also an aeronautical engineer, test pilot and college professor.
Recent progress in understanding mitokines as diagnostic and therapeutic targets in hepatocellular carcinoma
Authors: Wang Jiang , Luo Lan-Zhu , Liang Dao-Miao , Guo Chao , Huang Zhi-Hong , Jian Xiao-Hong , Wen Jie
Published: August 2023

Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.
Application effect of phloroglucinol injection in elderly patients with spastic abdominal pain in emergency department
Authors: Liu Yu-Fei , Chen Jian
Published: August 2023

Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.
Identification of key genes and biological pathways in lung adenocarcinoma by integrated bioinformatics analysis
Authors: Zhang Lin , Liu Yuan , Zhuang Jian-Guo , Guo Jie , Li Yan-Tao , Dong Yan , Song Gang
Published: August 2023

Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.
Clinical outcomes of robotic-assisted and manual total hip arthroplasty in the same patient: A case report
Authors: Hu Tian-Ye , Lin Dao-Chao , Zhou Yi-Jun , Zhang Zhi-Wu , Yuan Jia-Jun
Published: August 2023

Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.
Critical respiratory failure due to pregnancy complicated by COVID-19 and bacterial coinfection: A case report
Authors: Zhou Shuang , Liu Mei-Hong , Deng Xiao-Peng
Published: August 2023

Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.
Townes–Brocks syndrome with adult renal impairment in a Chinese family: A case report
Authors: Wu Jing , Zhang Jun , Xiao Tang-Li , He Ting
Published: August 2023

Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.
Anti-melanoma differentiation-associated gene 5 and anti-Ro52 antibody-dual positive dermatomyositis accompanied by rapidly lung disease: Three case reports
Authors: Ye Wen-Zheng , Peng Shan-Shan , Hu You-Hong , Fang Mu-Ping , Xiao Yu
Published: August 2023

Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.
Complex inferior vena cava reconstruction during ex vivo liver resection and autotransplantation: A case report
Authors: Humaerhan Jiayidaer , Jiang Tie-Min , Aji Tuerganaili , Shao Ying-Mei , Wen Hao
Published: August 2023

Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.
Supplemental tables for "Effects of Irrigation Methods and Scheduling on Water and Onion Productivity in Semi-arid Areas of Ethiopia"
Authors: Gebremicael Tesfay Gebretsadkan , Gebremeskel Gebremedhin , Kifle Mulubrhan , Gebremedhin Teferi , Deitch Matthew J. , Reda Kidane Welde , Reda Abbadi Girmay
Published: August 2023

Two tables as supplementary files for the manuscript "Effects of Irrigation Methods and Scheduling on Water and Onion Productivity in Semi-arid Areas of Ethiopia"
Invasive Non-Arthroplasty Treatment Options for Knee Osteoarthritis: Review
Authors: Reddy Rohan G , Wang YuChia , Scully Ryan , Thakkar Savyasachi C
Published: August 2023

Introduction: Knee osteoarthritis (KOA) is one of the most common joint diseases in the world, such that there exists a variety of treatment methods, ranging from conservative treatments such as physical therapy and weight loss to total replacement of the diseased joint. Invasive non-arthroplasty treatment methods are growing in popularity and this review aims to explore the current literature. Better understanding of these alternatives could allow orthopedic surgeons and primary care providers to offer poor arthroplasty candidates meaningful symptomatic relief. Materials and Methods: A literature review using PubMed, Google Scholar, and SCOPUS was performed to examine the following invasive non-arthroplasty treatment options: Corticosteroid injections (CS), viscosupplementation, platelet-rich plasma injections, stem cell injections, ozone therapy, prolotherapy, radiofrequency nerve ablation (RFA), arthroscopy, and osteotomy. Articles with complete data on the outcomes following these treatment methods were included in the study. Results: CSs showed strong efficacy in providing short-term pain relief, while viscosupplementation and platelet-rich plasma have shown to be effective in long-term management as well. Aside from the more common injectable treatment options, newer options such as stem cell injection and ozone therapy have shown clinical efficacy while prolotherapy and RFA are still early-stage treatment options. Still, further studies are required to better assess these emerging therapies. Operatively, arthroscopic surgery has shown to be minimally effective while osteotomy demonstrated effective pain and functional improvement. Conclusion: Multiple therapeutic options exist for invasive management of KOA to a different degree of effectiveness and efficacy. We have analyzed the outcomes of multiple invasive non-arthroplasty treatment options for KOA. This review can better inform patients and surgeons of the pros and cons of different KOA treatment methods. Newer conservative options may have positive clinical implications but will require further investigation. Operative alternatives to arthroplasty can provide symptomatic relief but may increase the associated risk and complexity should the need for arthroplasty ever arises. Keywords: Total knee arthroplasty, injections, radiofrequency nerve ablation, arthroscopy, osteotomy.
Reconfigurable intelligent surface-assisted free-space optical communication link for the Satellite-Internet of Things
Authors: Naik Ramavath Prasad , Simha G. D. Goutham , Kumar L. Bhargava , Krishnan Prabu
Published: August 2023

The Satellite-Internet of Things (S-IoT) is envisaged as one of the promising technological enhancements in this decade due to its outright connectivity, especially in the areas of terrestrial communication and weather forecasting. Invariably, turbulent atmospheric conditions and varied terrain profiles are hindrances for satellite based free-space optical (FSO) communication, and immensely disrupt signal levels. Recently, a new technological invention called a reconfigurable intelligent surface (RIS) empowered radio transmission environments for next generation wireless/optical technology has emerged. Elements of RIS are used to intelligently tune the striking beam towards desired locations. In this paper, we propose an RIS based FSO link to manueuver S-IoT. The challenges of pointing errors and turbulent atmospheric connectivity from a satellite to ground station and vice versa with the cooperation of RIS have been derived and substantiated with closed form solutions. The proposed system’s performance has been analyzed using packet and bit error rates, and outage probability over atmospheric turbulence, pointing errors, and signal blockage scenarios. Results are evaluated for different RIS elements as a function of average signal to noise ratio. The proposed system is extremely productive, since this scheme has the capability to provide dependable connectivity in rural, urban, and suburban environments where reliable connectivity is difficult in spite of traditional infrastructures.
Seasonal patterns of Schistosoma mansoni infection within Biomphalaria snails at the Ugandan shorelines of Lake Albert and Lake Victoria
Authors: Andrus Peter S. , Stothard J. Russell , Wade Christopher M.
Published: August 2023

Intestinal schistosomiasis is hyperendemic in many sub-Saharan African countries. In Uganda, it is endemic at both Lake Albert (LA) and Lake Victoria (LV) and caused by S. mansoni that uses Biomphalaria snails as obligatory intermediate snail hosts. To shed light on local patterns of infection, we utilised two PCR-based methods to detect S. mansoni within Biomphalaria spp. as collected at the Ugandan shorelines of Lake Albert and Lake Victoria from 2009–2010. Overall, at our Lake Albert sites, the mean infection prevalence was 12.5% (15 of 120 snails), while at our Lake Victoria sites the prevalence was 5% (3 of 60 snails). At our Lake Albert sites, the highest infection prevalence of 13.3% (8 of 60 snails) was at Walukuba, while at our Lake Victoria sites, the highest infection prevalence of 10% (2 of 20 snails) was at Lwanika. Three species of Biomphalaria, B. pfeifferi, B. stanleyi and B. sudanica, were identified at our Lake Albert collection sites, while only a single species, B. choanomphala, was identified at our Lake Victoria collection sites. Biomphalaria stanleyi (2 of 20 snails; 15%) had the highest infection prevalence, followed by B. sudanica (5 of 60 snails; 13.3%), B. pfeifferi (4 of 40 snails; 10%) and B. choanomphala (3 of 60 snails; 5%). Of the Biomphalaria species identified, B. choanomphala had the highest haplotype (gene) diversity score, followed by B. stanleyi, B. sudanica and B. pfeifferi. Sites with a higher mean prevalence of S. mansoni infection had higher intra-species haplotype diversity scores than sites with a lower mean prevalence. The wet seasons (LA: 13.3%; LV: 8.7%) had a consistently higher mean infection prevalence of S. mansoni than the dry seasons (LA: 9.5%; LV: 5%) for all species and all sites tested at both Lake Albert (n = 480) and Lake Victoria (n = 320), though the difference was not statistically significant.
Identification of high-risk factors for recurrence of colon cancer following complete mesocolic excision: An 8-year retrospective study
Authors: Liu Yuan , Du Wenyi , Guo Yi , Tian Zhiqiang , Shen Wei
Published: August 2023

Background

Colon cancer recurrence is a common adverse outcome for patients after complete mesocolic excision (CME) and greatly affects the near-term and long-term prognosis of patients. This study aimed to develop a machine learning model that can identify high-risk factors before, during, and after surgery, and predict the occurrence of postoperative colon cancer recurrence.

Methods

The study included 1187 patients with colon cancer, including 110 patients who had recurrent colon cancer. The researchers collected 44 characteristic variables, including patient demographic characteristics, basic medical history, preoperative examination information, type of surgery, and intraoperative information. Four machine learning algorithms, namely extreme gradient boosting (XGBoost), random forest (RF), support vector machine (SVM), and k-nearest neighbor algorithm (KNN), were used to construct the model. The researchers evaluated the model using the k-fold cross-validation method, ROC curve, calibration curve, decision curve analysis (DCA), and external validation.

Results

Among the four prediction models, the XGBoost algorithm performed the best. The ROC curve results showed that the AUC value of XGBoost was 0.962 in the training set and 0.952 in the validation set, indicating high prediction accuracy. The XGBoost model was stable during internal validation using the k-fold cross-validation method. The calibration curve demonstrated high predictive ability of the XGBoost model. The DCA curve showed that patients who received interventional treatment had a higher benefit rate under the XGBoost model. The external validation set’s AUC value was 0.91, indicating good extrapolation of the XGBoost prediction model.

Conclusion

The XGBoost machine learning algorithm-based prediction model for colon cancer recurrence has high prediction accuracy and clinical utility.
Genome size, genetic diversity, and phenotypic variability imply the effect of genetic variation instead of ploidy on trait plasticity in the cross-pollinated tree species of mulberry
Authors: Gnanesh Belaghihalli N. , Mondal Raju , G. S. Arunakumar , H. B. Manojkumar , Singh Pradeep , M. R. Bhavya , P Sowbhagya , Burji Shreyas M. , T. Mogili , V. Sivaprasad
Published: August 2023

Elucidation of genome size (GS), genetic and phenotypic variation is the fundamental aspect of crop improvement programs. Mulberry is a cross-pollinated, highly heterozygous tree eudicot, and comprised of huge ploidy variation with great adaptability across the world. However, because of inadequate information on GS, ploidy-associated traits, as well as the correlation between genetic and phenotypic variation hinder the further improvement of mulberry. In this present research, a core set of 157 germplasm accessions belonging to eight accepted species of Morus including promising functional varieties were chosen to represent the genetic spectrum from the whole germplasm collection. To estimate the GS, accessions were subjected to flow cytometry (FCM) analysis and the result suggested that four different ploidies (2n = 2x, 3x, 4x, and 6x) with GS ranging from 0.72±0.005pg (S-30) to 2.89±0.015pg (M. serrata), accounting~4.01 fold difference. The predicted polyploidy was further confirmed with metaphase chromosome count. In addition, the genetic variation was estimated by selecting a representative morphologically, diverse population of 82 accessions comprised of all ploidy variations using simple sequence repeats (SSR). The estimated average Polymorphism Information Content (PIC) and expected heterozygosity showed high levels of genetic diversity. Additionally, three populations were identified by the model-based population structure (k = 3) with a moderate level of correlation between the populations and different species of mulberry, which imply the effect of genetic variation instead of ploidy on trait plasticity that could be a consequence of the high level of heterozygosity imposed by natural cross-pollination. Further, the correlation between ploidies, especially diploid and triploid with selected phenotypic traits was identified, however, consistency could not be defined with higher ploidy levels (>3x). Moreover, incite gained here can serve as a platform for future omics approaches to the improvement of mulberry traits.
Response of soil microbial community diversity to continuous cucumber cropping in facilities along the Yellow River irrigation area
Authors: Huang Shuchao , Yu Jihua , Hou Dong , Yue Hongzhong , Zhang Dongqin , Li Yali , Lyu Jian , Jin Li , Jin Ning
Published: August 2023

Cucumber is an important cash crop; however, continuous cropping obstacles readily occur within the intensive production processes of facility horticulture. This study aimed to determine the effects of continuous cropping on soil quality and the microbial community in the rhizosphere soil of cucumbers. Rhizosphere soil of cucumber planted continuously for 4, 8, and 12 years was investigated, and soil that was not continuously planted was used as the control. Soil physicochemical properties, enzyme activity, microbial diversity, and richness were determined. The results showed that with the increase in continuous cropping years (0, 4, 8, and 12 years), soil total salt content continuously increased, while the pH value significantly decreased. Compared with the control, soil organic matter, alkali-hydrolyzed nitrogen, available phosphorus, available potassium, and nitrate nitrogen contents increased significantly after 4 and 8 years of continuous cropping. Spearman correlation analysis showed that pH was negatively correlated with sucrase or sucrose and available phosphorus was positively correlated with alkaline phosphatase. Compared with the control, the diversity and abundance of bacterial and fungal communities in cucumber rhizosphere soil decreased after 4 and 12 years of continuous cropping. Continuous cropping led to a significant increase in the richness of the dominant phylum of cucumber rhizosphere soil. Principal coordinates analysis showed that, compared with the control, the soil microbial community structure was significantly separated after 4, 8, and 12 years of continuous cropping, and the microbial community structure was most similar after 4 and 8 years of continuous cropping. In addition, redundancy analysis showed that pH was the main driver of soil microbial dominance. In conclusion, continuous cropping of cucumber along the Yellow River irrigation area has led to the deterioration of soil nutrients and microbial communities in that region. This experiment provides a theoretical foundation for addressing the challenges associated with continuous cropping in cucumber cultivation.
Youths’ perceptions and behaviors on COVID-19 testing
Authors: Arthur Caleb , Abenes Kathleen , Waselewski Marika , Chuisano Samantha A. , Chang Tammy
Published: August 2023

Background

Social gatherings are frequent sources of COVID-19 infections, especially among youth. However, little is known about youth testing behaviors before and after gatherings. Our aim was to assess behaviors and perceptions of youth related to testing for COVID-19 before or after social gatherings in order to inform efforts to reduce disease spread.

Methods

Five open-ended questions were texted to participants aged 14–24 throughout the United States via MyVoice. Using a content analysis approach, two investigators reviewed responses by question, developed a codebook, and independently applied codes. Discrepancies were resolved via discussion. Code frequency and demographic data were summarized using descriptive statistics.

Results

Of 1204 participants, 989 responded to at least one question (RR = 94.1%). The mean age was 20.2 years (SD: 2.4 years). Most participants (80.7%) reported testing for COVID-19 at least once. Most (70.6%) were likely to test following an event, especially “[i]f someone at the gathering tested positive,” while a smaller number (50.9%) endorsed testing prior to a gathering. Of youth who would not get tested, being vaccinated was the highest reported.

Conclusion

Youth in our nationwide sample are likely to test for COVID-19 after an event, though less likely if they are vaccinated. Their desire to test is primarily driven by symptoms, exposures, and requirements. Youth are interested in increased access to home testing. Youth-centered communications regarding testing recommendations and increased test availability for youth may reduce COVID-19 spread among young people and inform future pandemic recommendations.
Bayesian clustering of 109 worldwide countries according to the trend of prostate cancer mortality rates from 1990 to 2019
Authors: Mobaderi Tofigh , Kazemnejad Anoshirvan , Salehi Masoud
Published: August 2023

Neglecting possible growth heterogeneity and focusing only on the overall pattern of prostate cancer mortality rates can result in misunderstandings and incorrect conclusions about the growth process of the outcome. The main goal of this study was to capture the heterogeneity of prostate cancer mortality rates among countries from 1990 to 2019. To accomplish this aim, we performed the Bayesian latent Growth Mixture Model (GMM). In this longitudinal study, Prostate cancer mortality rates data from 1990 to 2019, as well as the Human Development Index (HDI), the Gross National Income (GNI), and the Life Expectancy at Birth (LEB), were obtained from WHO and UNDP platforms. The Bayesian GMM was used to discover homogeneous subgroups and estimate the pattern of prostate cancer mortality rates in each subgroup. The HDI, GNI and life expectancy effects were estimated using a Bayesian conditional Latent Growth Model (LGM). Globally, the intercept and the slope of the Bayesian LGM were equal to 8.77 and 0.19, respectively. The Bayesian GMM classified the 109 countries into four groups, which had significant positive growth patterns with different slopes except for the first class. The effect of HDI was not significant on the overall prostate cancer death rates, but GNI and LEB had a significantly positive effect on the model’s intercepts and a significantly negative effect on the slope. Although the prostate cancer mortality rate increased globally, it has four distinct latent subgroups with various patterns. Additionally, the effects of HDI, GNI, and LEB on prostate cancer mortality rates varied significantly among the four subgroups, indicating a need for further investigation to identify causal factors.
Ernest Lehman: The Sweet Smell of Success, Jon Krampner (2022)
Authors: Weisz Craig
Published: August 2023

Review of: Ernest Lehman: The Sweet Smell of Success, Jon Krampner (2022)

Lexington, KY: The University Press of Kentucky, 396 pp.,

ISBN 978-0-81319-595-7, h/bk, $27.73
Circularly Polarized Single-Layer Microstrip Reflectarray Fed With a 2x2 Microstrip Patch Array
Authors:   Instituto de Soldadura e Qualidade, Farias Roger , Peixeiro Custódio ,   Instituto Superior Técnico, Heckler Marcos ,   Universidade Federal do Pampa, Schlosser Edson ,   Universidade Federal do Pampa
Published: August 2023

The design of a single-band singly-layered reflectarray fed by a circularly polarized 2x2 microstrip patch antenna array with corporate feeding to be used in K-band (18.7–19.2 GHz) is proposed in this paper. It is demonstrated by simulations and measurements that the axial ratio bandwidth performance of the reflectarray depends strongly on the circularly polarization purity of the feeder. Simulated and measured results revealed that the complete reflectarray exhibits good performance in terms of input impedance with -10 dB input reflection coefficient bandwidth of 19.0 %, radiation pattern with 3 dB axial ratio bandwidth of 10.55 % and 3 dB gain bandwidth of 2.64 %.
Liquid Biopsies and Treatment Response
Authors:   Sunvalley Communication, LLC, Hofland Peter
Published: August 2023

Understanding the mechanisms of acquired resistance to targeted therapies in the treatment of cancer may help guide treatment strategies and improve clinical outcomes. [A new study, presented at the 19th World Congress on Gastrointestinal Cancer of the European Society of Medical Oncology (ESMO) shows that so-called liquid biopsies, blood tests that detect circulating tumor DNA (ctDNA), may not only sound an early alert that a treatment?s effect is diminishing, but may also help explain why – sometimes offering clues about what to do next.
Modelling of laminated glass interlayer by fractional viscoelasticity
Authors: Hálková Barbora , Schmidt Jaroslav
Published: August 2023

Fractional calculus, i.e. the theory of derivatives and integrals of non-integer order, can be efficiently used for the theoretical modelling of viscoelastic materials. Our research is focused on the polyvinyl butyral which is used as an interlayer for the laminated glass. Polyvinyl butyral can be classified as a viscoelastic material and the introduction of the fractional viscoelasticity seems to be appropriate tool for its description. This paper briefly introduces the springpot element and its connection into more complex theoretical models. We mainly consider the generalized Maxwell model in its standard and fractional form and show their application by fitting the data obtained by experimental analysis.
Comparison of behaviour of burnt beams models with effective and actual residual cross-sections in three point bending test
Authors: Keřková Kucíková Lucie , Šejnoha Michal , Janda Tomáš , Padevět Pavel
Published: August 2023

Glued laminated timber beams exposed to fire of a variable duration were tested in three point bending. Three types of model geometries taking into account the effect of burning were created. Each model was examined for five material data sets. The maximum deflection obtained from FEM simulations was compared with the corresponding deflection wel derived from a three point bending test of burnt beams. The analysis was performed with the help of Ansys® software limiting attention to a liner elasticity with the maximum applied force Fel selected at the proportionality limit observed experimentally. Majority of FEM models provided smaller deflections compared to measurements except for the material set adopting Young’s moduli from the compression test. The best fit was observed for the material data set obtained from homogenization. No predominant preference among individual geometries was found promoting the computational model based on reduced cross-section as sufficiently accurate.
The influence of lithium water glass on the durability of concrete
Authors: Vašířová Klára , Fládr Josef
Published: August 2023

The aim of the research is to verify the effect of lithium water glass on the durability and reduction of concrete absorption. For this purpose, the absorption test was made and the influence of the impregnation agent on durability when the test specimens are exposed to cyclic freezing and thawing was verified. Finally, the permeability of the test specimens was measured before and after impregnation. On the basis of the tests carried out, the effect of the impregnation agent was determined by comparing impregnated test specimens with reference specimens.