bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of obesity on outcomes of patients with acute respiratory distress syndrome: a retrospective analysis of a large clinical database
Authors: Lou Qiyan
Published: August 2023

Objective

To evaluate the link between obesity and mortality in patients with acute respiratory distress syndrome (ARDS).

Methods

We performed a retrospective cohort study of a large clinical database. A Cox proportional hazards regression model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the relationship between body mass index (BMI) and mortality. The primary endpoint was 30-day death rate and the secondary endpoints were 90-day and 1‑year mortality.

Results

Overall, 418 patients with ARDS were enrolled in the study, including 185 women and 233 men (age: 70.7 ± 44.1 years; BMI: 28.7 ± 8.1 kg/m2). Compared with patients with normal weight, obese patients were younger (60.1 ± 13.7, p = 0.003) and a higher percentage of these patients were women (51.3% vs. 49.0%, p = 0.001). The HRs (95% CI) of 30-day mortality in the underweight, overweight, and obese populations were 1.82 (0.85, 3.90), 0.59 (0.29, 1.20), and 3.85 (1.73, 8.57), respectively, after adjustment for other confounding factors. A similar pattern was also seen for death after 90 days and after 1 year. A U-shaped association between BMI and 30-day mortality was discovered by curve fitting.

Conclusion

Obesity had a significant impact on the short- and long-term mortality in patients with ARDS. There was a U-shaped relationship between BMI and mortality, while a higher BMI was associated with an increased risk of death in patients with ARDS.
Identification of KASP markers and candidate genes for drought tolerance in wheat using 90K SNP array genotyping of near-isogenic lines targeting a 4BS quantitative trait locus
Authors: Liu Guannan , Liu Dongcheng , Zhang Aimin , Liu Hui , Mia Md Sultan , Mullan Daniel , Yan Guijun
Published: August 2023

Key message

This study identified a novel SNP and developed a highly efficient KASP marker for drought tolerance in wheat by genotyping NILs targeting a major QTL for drought tolerance using an SNP array and validation with commercial varieties.

Common wheat (Triticum aestivum L.) is an important winter crop worldwide and a typical allopolyploid with a large and complex genome. With global warming, the environmental volatility and incidence of drought in wheat-producing areas will increase. Molecular markers for drought tolerance are urgently needed to enhance drought tolerance breeding. Here, we genotyped four near-isogenic line (NIL) pairs targeting a major QTL qDSI.4B.1 on wheat chromosome arm 4BS for drought tolerance using the 90K SNP Illumina iSelect array and discovered a single nucleotide polymorphism (SNP) (Excalibur_c100336_106) with consistent genotype–phenotype associations among all four NIL pairs and their parents. Then, we converted the SNP into a Kompetitive Allele-Specific PCR (KASP) marker, with an accuracy of 100% for the four NIL pairs and their parents and as high as 81.8% for the 44 tested wheat lines with known phenotypes collected from Australia and China. Two genes near this SNP were suggested as candidate genes for drought tolerance in wheat after checking the Chinese Spring reference genome annotation version 1.1. One gene, TraesCS4B02G085300, encodes an F-box protein reportedly related to the ABA network, a main pathway for drought tolerance, and another gene, TraesCS4B02G085400, encodes a calcineurin-like metallophos-phoesterase transmembrane protein, which participates in Ca2+-dependent phosphorylation regulatory system. Based on this work and previous research on pre-harvest sprouting, we established a quick and efficient general SQV-based approach for KASP marker development, integrating genotyping by SNP arrays (S) using NILs targeting major QTL for a specific trait (Q) and validating them with commercial varieties (V). The identified SNP and developed KASP marker could be applied to marker-assisted selection in drought breeding, and further study of the candidate genes may improve our understanding of drought tolerance in wheat.
The potential role of ChatGPT and artificial intelligence in anatomy education: a conversation with ChatGPT
Authors: Totlis Trifon , Natsis Konstantinos , Filos Dimitrios , Ediaroglou Vasilios , Mantzou Nikolaos , Duparc Fabrice , Piagkou Maria
Published: August 2023

Purpose

A recent study published in the JMIR Med Educ Journal explored the potential impact of the Generative Pre-Train (ChatGPT), a generative language model, on medical education, research, and practice. In the present study, an interview with ChatGPT was conducted to determine its capabilities and potential for use in anatomy education (AE) and anatomy research (AR).

Methods

The study involved 18 questions asked of ChatGPT after obtaining an online subscription to the 4th edition. The questions were randomly selected and evaluated based on accuracy, relevance, and comprehensiveness.

Results

The ChatGPT provided accurate and well-structured anatomical descriptions, including clinical relevance and relationships between structures. The chatbot also offered concise summaries of chapters and helpful advice on anatomical terminology, even with complex terms. However, when it came to anatomical variants and their clinical significance, the chatbot’s replies were inadequate unless variants were systematically classified into types. ChatGPT-4 generated multiple-choice quizzes and matching questions of varying difficulty levels, as well as summaries of articles when presented with text. However, the chatbot recognized its limitations in terms of accuracy, as did the authors of the current study.

Conclusion

ChatGPT-4 can be a valuable interactive educational tool for students in the field of anatomy, encouraging engagement and further questions. However, it cannot replace the critical role of educators and should be used as a complementary tool. Future research should establish guidelines for ChatGPT’s optimal use and application in medical education.
Inadvertent intraocular injection of methylprednisolone in a patient with prior superior oblique tuck surgery
Authors: Felcida Vinaya , Tyagi Ajai K. , Kalogeropoulos Dimitrios
Published: August 2023

Background

To report inadvertent intraocular methylprednisolone injection into an eye that had previously undergone superior oblique tuck surgery.

Material and methods

An observational case report.

Results

An inadvertent intraocular penetration occurred following periorbital methylprednisolone injection, which was performed via the superonasal quadrant to relieve trochlear pain in an eye that had undergone previous superior oblique tuck procedure. There was immediate loss of vision, afferent pupillary defect, and raised intraocular pressure. Fundoscopy revealed intravitreal and subretinal methylprednisolone with retinal detachment. Immediate removal of intravitreal and subretinal methylprednisolone was performed with a retinal reattachment procedure. Postoperatively, retinal necrosis was noted in the area that was in contact with methylprednisolone.

Conclusions

This case highlights the risk of inadvertent intraocular penetration while injecting through a limited periorbital space that has been previously operated on.
New progress of tuberculosis scar carcinoma
Authors: Sun Wenwen , Liu Yujin , Zhao Lishu , Wang Hao , Ye Li , Liu Xinyue , Xu Kandi , Chen Yu , Fan Lin
Published: August 2023

It has been demonstrated that scar tissue and fibrosis may increase the likelihood of developing malignancies. Specifically, scar tissue has been linked to the occurrence and progression of lung cancer (LC), though the precise mechanisms necessitate further research for explanation. Lung scarring can stem from various causes, with carcinogenesis on scarring lesions in pulmonary tuberculosis (PTB) being the most frequent (accounting for approximately 75% of cases). Notably, having previously cured, PTB is the second most common risk factor for LC after smoking, with approximately 3% of PTB patients experiencing LC as a secondary condition. This essay will delve into the mechanisms, treatment, and prognosis of tuberculosis scar carcinoma (TSC).
Burning Rate of Wood Cribs with Controlled Airflow
Authors: McAllister S. , Grumstrup T.
Published: August 2023

There is a dire need to improve our prediction capabilities of wildland fire behavior in a range of conditions from marginal burning to the most extreme. In order to develop a more physically-based operational wildland fire behavior model, we need to improve our understanding of the effect of ventilation on burning rate of fuel beds. In this work, wood cribs are used as a simplified fuel bed. A variety of crib designs were tested with stick sizes ranging from 0.32 cm to 1.27 cm and porosities ranging from densely packed to loosely packed. A pressurized box was built that allowed for a controlled flow rate of air through the cribs from 100 LPM to 1000 LPM. The mass loss rates with forced ventilation were compared to tests conducted outside of the box under unrestricted quiescent conditions. For the flow rates tested here, the burning rate was generally observed to increase with flow. The amount of air naturally induced into a crib while burning was deduced to be best related to the vent area and the square root of the stick spacing (Avs1/2). It was seen that the air-to-fuel ratio inside a fuel bed burning in quiescent conditions is approximately 1.11, indicating that over 75% of the air required to completely combust the pyrolysis gases is entrained in the plume. When the supplied air is less than the amount normally entrained in ambient burning, the crib is under-ventilated and the proportional reduction in the burning rate does not seem to depend on the crib characteristics. When the crib is over-ventilated, however, the relative increase in the burning rate does vary with crib design. Simple physical arguments were used to correlate the data. Future work will include testing at higher flow rates, different moisture contents, and with cribs built with multiple stick thicknesses.
Using Sequential Pattern Mining to Understand How Students Use Guidance While Doing Scientific Calculations
Authors: Verstege Sjors , Zhang Yingbin , Wierenga Peter , Paquette Luc , Diederen Julia
Published: August 2023

In natural science education, experiments often lead to the collection of raw data that need to be processed into results by doing calculations. Teaching students how to approach such calculations can be done using digital learning materials that provide guidance. The goal of this study was to investigate students’ behaviour regarding the use of guidance while doing scientific multi-step calculations, and to relate this behaviour to learning. Sequential pattern mining was used to i) identify students’ behaviour patterns while doing calculations in an online learning environment, ii) study the relation between use of guidance and success on first attempt at submitting a calculated value, iii) study the relation between students’ use of guidance and learning gain, and iv) study the relation between students’ use of guidance and prior knowledge. Data showed that all students frequently used the guidance provided in the learning task. Moreover, students who used the option to check their intermediate calculations and students who studied worked examples were more likely to successfully complete the calculation on their first attempt than students who did not use this guidance. Guidance in the form of hints was used frequently. However, using the hints did not result in more success at the first attempt. We did not find a relation between learning gain and use of guidance, but we did find a trend that students with a low prior knowledge used more guidance compared to students with a high prior knowledge. The results of this study imply that providing hints and intermediate calculations is of utmost importance for students to independently complete scientific multi-step calculations.
The Measurement of Soret and Thermodiffusion Coefficients in Binary and Ternary Liquid Mixtures
Authors: Köhler W. , Mialdun A. , Bou-Ali M. M. , Shevtsova V.
Published: August 2023

This review provides an overview of the major, currently used techniques for investigating the Soret effect and measuring thermodiffusion and Soret coefficients, and in most cases also isothermal Fickian diffusion coefficients, in liquid mixtures. The methods are introduced with a focus on binary mixtures. The optical methods comprise optical beam deflection (OBD), optical digital interferometry (ODI) both on the ground and under microgravity conditions in the SODI-IVIDIL experiment for the study of the influence of vibrations onboard the International Space Station, which are all based on Soret cells. The transient holographic grating technique of thermal diffusion-forced Rayleigh scattering (TDFRS) employs light not only for detection of the concentration changes but also for optical volume heating. Thermogravitational columns (TGC) utilize the coupling between convection and thermodiffusion to create concentration changes inside a vertical column with a horizontal temperature gradient. While samples are analyzed after extraction from the column in a classical setup, the recently developed transparent microcolumn allows for interferometric in situ monitoring of the concentration field. The most recent technique relies on the measurement of giant non-equilibrium fluctuations (NEFs) by small-angle light scattering techniques. Research on ternary mixtures, both on the ground and in microgravity, has gained momentum in the context of the DCMIX microgravity project of ESA. Most techniques employed for binaries can be extended to ternaries by introducing a second detection color or by analyzing both refractive index and density of extracted TGC samples. The accuracy is limited by the unavoidable inversion of the so-called contrast factor matrix.
From Paratexts to Print Machinery
Authors: Goh Benjamin
Published: August 2023

This article seeks to decentre the proprietary author in copyright law by attending to some peripheral matters of Immanuel Kant’s periodical essay, ‘On the Wrongfulness of Reprinting’ (1785), as indices of its medial-material conditions of possibility. We consider not only the epitextual background of the German Enlightenment in which the Berlinische Monatsschrift was produced, but also the peritextual specimens of catchwords, signature marks, and various front matter of Kant’s essay. This medial reading suggests the periodical to be deeply involved in the operations of a print machinery preceding the authorial figure, the existence of which perturbs copyright law’s attachment to original authorship.
Comparative evaluation of uncertainty estimation and decomposition methods on liver segmentation
Authors: Cangalovic Vanja Sophie , Thielke Felix , Meine Hans
Published: August 2023

Purpose

Deep neural networks need to be able to indicate error likelihood via reliable estimates of their predictive uncertainty when used in high-risk scenarios, such as medical decision support. This work contributes a systematic overview of state-of-the-art approaches for decomposing predictive uncertainty into aleatoric and epistemic components, and a comprehensive comparison for Bayesian neural networks (BNNs) between mutual information decomposition and the explicit modelling of both uncertainty types via an additional loss-attenuating neuron.

Methods

Experiments are performed in the context of liver segmentation in CT scans. The quality of the uncertainty decomposition in the resulting uncertainty maps is qualitatively evaluated, and quantitative behaviour of decomposed uncertainties is systematically compared for different experiment settings with varying training set sizes, label noise, and distribution shifts.

Results

Our results show the mutual information decomposition to robustly yield meaningful aleatoric and epistemic uncertainty estimates, while the activation of the loss-attenuating neuron appears noisier with non-trivial convergence properties. We found that the addition of a heteroscedastic neuron does not significantly improve segmentation performance or calibration, while slightly improving the quality of uncertainty estimates.

Conclusions

Mutual information decomposition is simple to implement, has mathematically pleasing properties, and yields meaningful uncertainty estimates that behave as expected under controlled changes to our data set. The additional extension of BNNs with loss-attenuating neurons provides no improvement in terms of segmentation performance or calibration in our setting, but marginal benefits regarding the quality of decomposed uncertainties.
The Role of Nanocrystallization for the Enhancement of Structural, Electrical, and Transport Properties of BaTiO3-V2O5-PbO Glasses
Authors: Morad Ibrahim , Harby Amany E. , Ayoub M. S. , Ali H. Elhosiny , El-Desoky M. M.
Published: August 2023

Glass-ceramic nanocrystals (GCNs) were created via annealing at crystallization temperature Tc for the parent BaTiO3-V2O5-PbO glasses prepared by the melt quenching technique. The amorphous character of the existing quenched glasses was confirmed by scanning electron microscopy. Furthermore, the general characteristics of x-ray diffraction support the amorphous nature of the glasses. In the related heat-treated samples, the typical nanostructure size is less than 60 nm. It was discovered that an increase in the density of the GCNs occurred with an increase in the BaTiO3 percentage. Also, with increasing BaTiO3 content, a slight increase was observed in the crystallization and glass transition temperature from 335°C to 365°C and 265°C to 320°C, respectively. It was revealed that suitable nanocrystallization at temperatures around the onset of Tc for 1 h was able to significantly increase the electronic conductivity of the initial glasses. The accumulation of V4+–V5+ pairs at the interlayer zones created between nanocrystallites and the glassy phase were accountable for electron hopping in the current approach, which was significantly higher than in the glass phase. The experimental findings were investigated in a model based on the “core–shell” idea. Appropriate values for the different small polaron hopping (SPH) variables were found from the best fits. Non-adiabatic hopping of small polarons was responsible for the conduction. As a result of the alteration of the nanostructure, conductivity was enhanced. Compared to the original glasses, the final materials have significantly better electrical conductivity. Such characteristics can be utilized in the design for industrial applications.
Long-term Follow-up 15 Years After Duodenal Switch or Gastric Bypass for Super Obesity: a Randomized Controlled Trial
Authors: Möller Filip , Hedberg Jakob , Skogar Martin , Sundbom Magnus
Published: August 2023

Background

In super obesity, Roux-en-Y gastric bypass (RYGB) may be insufficient why some surgeons advocate biliopancreatic diversion with duodenal switch (BPD/DS), a more malabsorptive procedure. There is a paucity of evidence regarding results beyond 10 years, especially after BPD/DS. The aim of this randomized controlled trial was to compare the long-term outcome of BPD/DS, and RYGB in patients with super obesity, i.e., body mass index (BMI) > 50 kg/m2.

Methods

This is a 13- to 17-year follow-up study of a single-center, single-blinded randomized trial in which 47 patients (BMI > 48 and eligible for bariatric surgery) were randomized 1:1 to BPD/DS and RYGB (25 men, 24 BPD/DS, 39.1 ± 9.9 years, BMI 54.5 ± 6.1 kg/m2). The primary outcome was weight loss. The study was financed by Swedish governmental funding of clinical research (ALF). Trial registration number: ISRCTN10940791.

Results

Thirty-four (18 BPD/DS) of the living 42 patients (81.0%) participated. BPD/DS resulted in higher BMI loss (20.4 ± 7.9 vs. 12.4 ± 8.6, p = .008) and higher percent of total body weight loss (37.5% ± 12.2 vs. 22.8% ± 14.8, p = .004). BPD/DS was associated with lower fasting glucose, glycated hemoglobin (HbA1c), and low-density lipoprotein (LDL) as well as lower hemoglobin. Adverse events were more common after BPD/DS (2.7 vs. 0.9 per patient, p = .004). The global assessment tool BAROS (Bariatric Analysis and Reporting Outcome System) demonstrated superior scores for BPD/DS (p = .047).

Conclusion

When compared to RYGB, BPD/DS results in superior weight loss and metabolic control as well as superior BAROS score, however, at the cost of more adverse events.

Graphical Abstract
Influence of news media use and political discussions on social self-efficacy through sense of unity: an analysis of mediation model invariance with Spanish and Portuguese adolescents
Authors: Salado Vanesa , Gaspar Tania , Moreno-Maldonado Concepción , de Matos Margarida Gaspar , Rivera Francisco
Published: August 2023

Discussing sociopolitical issues with family or friends during adolescence, as well as staying informed through media outlets, is key to developing active civic engagement for both youth and future adults. Likewise, these communicative exchanges promote a sense of belonging and social skills which foster adolescents’ wellbeing. This research aims to analyze the influence of participation in communication about political and social issues on adolescents’ social self-efficacy, both directly and as well as indirectly through sense of unity, in two Mediterranean countries (Portugal and Spain). The sample was selected through random multistage sampling by conglomerates. The 36,992 adolescents (50.6% girls and 49.4% boys) participated in the Health Behaviour in School-aged Children (HBSC) study in Portugal and Spain, and the age groups were distributed as following: 39.6% 13–14-years-old; 35.8% 15–16-years-old; and 25.6% 17–18-years-old. Analyses showed positive associations between the proposed indicator of civic engagement –news media use and political discussions– and social self-efficacy, both directly as well as through sense of unity, with similar results for adolescents in Portugal and Spain. Accordingly, educational programs promoting communication about sociopolitical issues could foster adolescents’ sense of unity and social skills, contributing to their positive development, wellbeing, and civic engagement. Curricular materials on current politics and social affairs could increase classroom dialogue based on respect, healthy peer relationships, and sense of belonging, fostering effective political socialization amongst youth and the development of democratic behaviors beneficial to society.
Moralisation of medicines: The case of hydroxychloroquine
Authors: Lalumera Elisabetta
Published: August 2023

The concept of moralisation of health behaviours was introduced in social psychology to describe the attribution of moral properties to habits and conditions like smoking or being a vegetarian. Moral properties are powerful motivators for people and institutions, as they may trigger blame, stigma, and appraisal, as well as the polarisation of interest and scientific hype. Here I extend the concept and illustrate how medicines and treatments can be seen as if they had moral properties, too, when they come to be regarded as good or bad in the moral sense, and not just in the instrumental sense of benefiting or harming health. I propose the hydroxychloroquine (HCQ) controversy of 2020 as an example of moralisation of a medicine. HCQ and chloroquine are anti-malarial drugs, whose off-label use for Covid-19 was hotly discussed in the early months of the pandemic, both in the media and within the scientific community, and eventually dismissed when robust evidence came out. The point of the paper is to show that moralisation of health products and treatments may influence individual and institutional decisions in significant ways, and also affect research. For these reasons, it should be carefully monitored and critically assessed.
Gravity field modelling in mountainous areas by solving the nonlinear satellite-fixed geodetic boundary value problem with the finite element method
Authors: Macák Marek , Minarechová Zuzana , Čunderlík Róbert , Mikula Karol
Published: August 2023

The paper concerns a novel concept based on the iterative approach applied for solving the nonlinear satellite-fixed geodetic boundary value problem (NSFGBVP) using the finite element method (FEM). We formulate the NSFGBVP that consists of the Laplace equation defined in the 3D bounded domain outside the Earth, the nonlinear boundary condition (BC) prescribed on the disretized Earth’s surface, and the Dirichlet BC given on a spherical boundary placed approximately at the altitude of GOCE satellite mission and additional four side boundaries. The iterative approach is based on determining the direction of actual gravity vector together with the value of the disturbing potential. Such a concept leads to the first iteration where the oblique derivative boundary value problem is solved, and the last iteration represents the approximation of the actual disturbing potential and the direction of gravity vector. As a numerical method for our approach, we implement the FEM with triangular prisms. High-resolution numerical experiments deal with the local gravity field modelling in the Andean, Himalayan and Alpine mountain range, where we focus on the contribution to the disturbing potential solution by solving the nonlinear geodetic boundary value problem in comparison with the solution to the oblique derivative geodetic boundary value problem. The obtained results showed the maximal contribution of the presented approach 0.0571 [$${\text{m}}^{{\text{2}}} {\text{s}}^{{{\text{ - 2}}}}$$

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Dialogic Reading Effect on Communicative Initiations and Responses for Children with Autism: a Systematic Review
Authors: Alharbi Hadeel , Terlektsi Emmanouela , Kossyvaki Lila
Published: August 2023

Dialogic reading (DR) is an evidence-based interactive shared reading intervention. This systematic review investigated the effect of DR interventions on the communicative initiations and responses of children with autism, an area of great difficulty for most individuals with autism. More precisely, the paper aimed to (a) describe the characteristics of DR interventions, (b) evaluate the outcomes and effectiveness of DR interventions, and (c) synthesize the quality of the studies. Nine experimental studies were included in the review in which the original DR intervention or adapted versions of it were examined. All studies provided strong to adequate research report strength. Although the review showed inconsistent effects of the interventions on the communicative initiations and responses of children with autism, it concluded that DR can be a promising and beneficial shared reading intervention.
Grossman–Hart–Moore Goes to Italy: Rethinking the Boundaries of the Firm
Authors: De Ponti Pietro , Gattai Valeria , Natale Piergiovanna
Published: August 2023

This paper provides new empirical evidence on the boundaries of the firm, as shaped by the ownership (make-or-buy) and location (domestic-or-foreign) decisions of sourcing. In particular, we draw on the Grossman–Hart–Moore framework to investigate the role of input characteristics, investment spillovers and firm productivity in ownership and location decisions. For the purpose of the empirical analysis, we rely on original survey data of a stratified sample of Italian manufacturing firms, headquartered in Lombardy. Our probit, multinomial probit and conditional mixed process estimations suggest a number of robust regularities. Some of them confirm so far unexplored theoretical predictions from the Grossman–Hart–Moore framework; others provide new insights on specific relationships on which the theory is silent. As for ownership, we find that reliance on specific inputs and intangible inputs fosters integration over non-integration; moreover, firms acknowledging cross spillover effects are more likely to opt for joint-venture than non-integration. As for location, domestic sourcing prevails over foreign sourcing in presence of investment spillovers, whereas input characteristics play no role. Lastly, productivity is a major driver of the boundaries of the firm in that productive firms are more likely to source abroad than domestically. Holding across different econometric models and a number of robustness checks, our results contribute to the property rights theory of the firm and its recent developments.
Trakls Tönen – Die systematische linguistische Rekonstruktion literaturwissenschaftlicher Interpretationen des Verses Der Flug der Vögel tönt von alten Sagen
Authors: Engelberg Stefan
Published: August 2023

Die Gedichte Georg Trakls gelten allgemein als semantisch schwer zugänglich und stellen Gedichtinterpretationen vor einige Herausforderungen. Im Zentrum dieses Aufsatzes steht ein einzelner satzwertiger Vers aus einem Gedicht Trakls. Ziel ist es zu zeigen, wie literaturwissenschaftliche Interpretationen dieses Verses linguistisch rekonstruiert werden können, und zwar auf der Basis von grundlegenden lexikalischen Eigenschaften, Prozessen der Bedeutungsverschiebung, pragmatisch basierten Anreicherungsprozessen, Welt- und literarischem Wissen und insbesondere detaillierten Annahmen zur Argumentstruktur. Die changierende Bedeutung des untersuchten Verses, so eine der Schlussfolgerungen dieses Aufsatzes, basiert dabei neben Uminterpretationen und Bedeutungsanreicherungen insbesondere auf der Amalgamierung verschiedener Argumentstrukturmuster.
T2T-YAO: A Telomere-to-Telomere Assembled Diploid Reference Genome for Han Chinese
Authors: He Yukun , Chu Yanan , Guo Shuming , Hu Jiang , Li Ran , Zheng Yali , Ma Xinqian , Du Zhenglin , Zhao Lili , Yu Wenyi , Xue Jianbo , Bian Wenjie , Yang Feifei , Chen Xi , Zhang Pingan , Wu Rihan , Ma Yifan , Shao Changjun , Chen Jing , Wang Jian , Li Jiwei , Wu Jing , Hu Xiaoyi , Long Qiuyue , Jiang Mingzheng , Ye Hongli , Song Shixu , Li Guangyao , Wei Yue , Xu Yu , Ma Yanliang , Chen Yanwen , Wang Keqiang , Bao Jing , Xi Wen , Wang Fang , Ni Wentao , Zhang Moqin , Yu Yan , Li Shengnan , Kang Yu , Gao Zhancheng
Published: August 2023

Since its initial release in 2001, the human reference genome has undergone continuous improvement in quality, and the recently released telomere-to-telomere (T2T) version — T2T-CHM13 — reaches its highest level of continuity and accuracy after 20 years of effort by working on a simplified, nearly homozygous genome of a hydatidiform mole cell line. Here, to provide an authentic complete diploid human genome reference for the Han Chinese, the largest population in the world, we assembled the genome of a male Han Chinese individual, T2T-YAO, which includes T2T assemblies of all the 22 + X + M and 22 + Y chromosomes in both haploids. The quality of T2T-YAO is much better than those of all currently available diploid assemblies, and its haploid version, T2T-YAO-hp, generated by selecting the better assembly for each autosome, reaches the top quality of fewer than one error per 29.5 Mb, even higher than that of T2T-CHM13. Derived from an individual living in the aboriginal region of the Han population, T2T-YAO shows clear ancestry and potential genetic continuity from the ancient ancestors. Each haplotype of T2T-YAO possesses ∼ 330-Mb exclusive sequences, ∼ 3100 unique genes, and tens of thousands of nucleotide and structural variations as compared with CHM13, highlighting the necessity of a population-stratified reference genome. The construction of T2T-YAO, an accurate and authentic representative of the Chinese population, would enable precise delineation of genomic variations and advance our understandings in the hereditability of diseases and phenotypes, especially within the context of the unique variations of the Chinese population.
Slingshot Prominences, Formation, Ejection and Cycle Frequency in Cool Stars
Authors: Daley-Yates S. , Jardine M. M.
Published: August 2023

Stars lose mass and angular momentum during their lifetimes. Observations of H-alpha absorption of a number of low mass stars, show prominences transiting the stellar disc and being ejected into the extended stellar wind. Analytic modelling have shown these M-dwarf coronal structures growing to be orders of magnitude larger than their solar counterparts. This makes prominences responsible for mass and angular momentum loss comparable to that due to the stellar wind. We present results from a numerical study which used magnetohydrodynamic simulations to model the balance between gravity, magnetic confinement, and rotational acceleration. This allows us to study the time dependent nature of prominence formation. We demonstrate that a prominence, formed beyond the co-rotation radius, is ejected into the extended stellar wind in the slingshot prominence paradigm. Mass, angular momentum flux and ejection frequency have been calculated for a representative cool star, in the so-called Thermal Non-Equilibrium (TNE) regime.
Physics of the atmospheric escape driven by EUV photoionization heating: Classification of the hydrodynamic escape in close-in planets
Authors: Mitani Hiroto , Nakatani Riouhei , Yoshida Naoki
Published: August 2023

The intense extreme ultraviolet radiation heats the upper atmosphere of close-in exoplanets and drives the atmospheric escape. The escaping process determines the planetary evolution of close-in planets. The mass loss rate depends on the UV flux at the planet. We introduce the relevant physical quantities which describe the dominant physics in the atmosphere. We find that the equilibrium temperature and the characteristic temperature determine whether the system becomes energy-limited or recombination-limited. We classify the observed close-in planets using the physical conditions. We also find that many of the Lyman-α absorptions detected planets receive intenser flux than the critical flux which can be determined from physical conditions. Our classification method can quantitatively reveal whether the EUV is not strong enough to drive the outflow or the Lyman- α absorption is not detected for some reason (e.g. stellar wind confinement). We also discuss the thermo-chemical structure of hydrodynamic simulations with the relevant physics.
Magnetic confinement in the wind of low mass stars
Authors: Waugh Rose F. P. , Jardine Moira M.
Published: August 2023

Magnetic confinement of material is observed on both high and low mass stars. On low mass stars, this confinement can be seen as slingshot prominences, in which condensations are supported several stellar radii above the surface by strong magnetic fields. We present a model for generating cooled field lines in equilibrium with the background corona, which we use to populate a model corona. We find prominence masses on the order of observationally derived values. We find two types of solutions: footpoint heavy “solar-like prominences” and summit heavy “slingshot prominences” which are centrifugally supported. These can form within the open field region i.e. embedded in the wind. We generate Hα spectra from different field structures and show that all display behaviour that is consistent with observations. This implies that the features seen in observations could be supported by a range of conditions, suggesting they would be common across rapidly rotating stars.
Planet migration in accretion discs in binary systems
Authors: Nekrasov A.D. , Popov S.B. , Zhuravlev V.V.
Published: August 2023

We model evolution of exoplanets of S-type in close binary systems at the stage when the companion starts to lose mass via a slow stellar wind. At this stage an accretion disc is formed around the planets’ host. Detailed structure of such discs is calculated in quasi-stationary and non-stationary approaches. We model migration of planets embedded in these discs.
Water and silicon-monoxide masers monitored towards the “water fountain” sources
Authors: Imai H. , Amada K. , Gómez J. F. , Uscanga L. , Tafoya D. , Nakashima K. , Shum K.-Y. , Hamae Y. , Burns R. , Orosz G.
Published: August 2023

We have investigated the evolution of 12 “water fountain” sources in real time in the accompanying H2O 2o and SiO masers through our FLASHING (Finest Legacy Acquisitions of SiO-/ H2O 2o-maser Ignitions by Nobeyama Generation) project. It has been confirmed that these masers are excellent probes of new jet blob ejections, acceleration of the material supplied from the parental circumstellar envelope and entrained by the stellar jets yielding its deceleration. Possible periodic variations of the maser emission, reflecting properties of the central dying stars or binary systems, will be further investigated.
Role of planetary winds in planet evolution and population
Authors: Modirrousta-Galian D.
Published: August 2023

The role of atmospheric evaporation in shaping exoplanet populations remains a major unsolved problem in the literature. Observational evidence, like the bimodal distribution of exoplanet radii, suggests a catastrophic past in which exoplanets with masses of approximately 1–10M⊕ often lose their primordial envelopes and experience a drastic reduction in their radii. Our knowledge of the mechanisms behind atmospheric evaporation remains nebulous, with new models regularly introduced in the literature. Understanding the principles behind these models and knowing when to apply them is essential for constraining how planets evolve. This communication reviews the mechanisms behind atmospheric evaporation by exploring observations and theory, as well as introducing some of the principles in the forthcoming paper Modirrousta-Galian & Korenaga (in press).
Interaction between massive star winds and the interstellar medium
Authors: Mackey Jonathan
Published: August 2023

Massive stars drive strong winds that impact the surrounding interstellar medium, producing parsec-scale bubbles for isolated stars and superbubbles around young clusters. These bubbles can be observed across the electromagnetic spectrum, both the wind itself and the swept up interstellar gas. Runaway massive stars produce bow shocks that strongly compresses interstellar gas, producing bright infrared, optical and radio nebulae. With the detection of non-thermal radio emission from bow shocks, particle acceleration can now also be investigated. I review research on wind bubbles and bow shocks around massive stars, highlighting recent advances in infrared, radio and X-ray observations, and progress in multidimensional simulations of these nebulae. These advances enable quantitative comparisons between theory and observations and allow to test the importance of some physical processes such as thermal conduction and Kelvin-Helmholtz instability in shaping nebulae and in constraining the energetics of stellar-wind feedback to the interstellar medium.
Hydrodynamic disk solutions for Be stars using HDUST
Authors: Arcos C. , Curé M. , Araya I. , Rubio A. , Carciofi A.
Published: August 2023

. In this work, we implemented a hydrodynamical solution for fast rotating stars, which leaves high values of mass-loss rates and low terminal velocities of the wind. This 1D density distribution adopts a viscosity mimicking parameter which simulates a quasi-Keplerian motion. Then, it is converted to a volumetric density considering vertical hydrostatic equilibrium using a power-law scale height, as usual in viscous decretion disk models. We calculate the theoretical hydrogen emission lines and the spectral energy distribution utilizing the radiative transfer code HDUST. Our disk-wind structures are in agreement with viscous decretions disk models.
The Driving of Hot Star Winds
Authors: Sander Andreas A.C.
Published: August 2023

In the regime of hot stars, winds were not seen as a common thing until the era of UV astronomy. Since we have access to the UV wavelength range, it has become clear that winds are not an exotic phenomenon limited to some special objects, but actually ubiquitous among hot and massive stars. The opacities due to spectral lines are the decisive ingredient that allows hot, massive stars to launch powerful winds. While the fundamental principles of these so-called line-driven winds have been realized decades ago, their proper quantitative prediction is still a major challenge today. Established theoretical and empirical descriptions have allowed us to make major progress on all astrophysical scales. However, we are now reaching their limitations as we still lack various fundamental insights on the nature of hot star winds, thereby hampering us from drawing deeper conclusions, not least when dealing with stellar or sub-stellar companions. This has spawned a new generation of researchers searching for answers with a yet unprecedented level of detail in observational and new theoretical approaches.

In these proceedings, the fundamental principles of driving hot star winds will be briefly reviewed. Starting from the classical CAK theory and its extensions, over Monte Carlo and recent comoving-frame-based simulations, the different methods to describe and model the acceleration of hot star winds will be introduced. The review continues with briefly discussing instabilities as well as qualitative and quantitative insights for OB- and Wolf-Rayet-star winds. Moreover, the challenges of companions and their impact on radiation-driven winds are outlined.
Weakening the wind with ULLYSES: Examining the Bi-Stability Jump
Authors: Verhamme Olivier , Sundqvist Jon Olof
Published: August 2023

Radiation-driven mass-loss is an important, but still highly debated, driver for the evolution of massive stars. Current massive star evolution models rely on the theoretical prediction that low luminosity massive stars experience a sudden increase in mass loss below a stellar effective temperature of about 20 000 K. However, novel radiation-driven mass-loss rate predictions show no such bi-stability jump, which effects the post main-sequence evolution of massive stars. The ULLYSES data set provides a unique opportunity to investigate the theoretical bi-stability jump dichotomy and may help to assess the existence of the bi-stability jump in massive star winds. By utilising UV spectra from ULLYSES combined with X-shooter optical data we obtain empirical mass-loss rate constraints, that are no longer degenerate to the effects of wind clumping, and derive novel empirical constraints on the mass-loss behavior across the temperature range of the bi-stability jump. Current preliminary results do not show a clear presence of a bi-stability jump.
The Evolution of Atmospheric Escape of Highly Irradiated Gassy Exoplanets
Authors: Allan Andrew P. , Vidotto Aline A. , Dos Santos Leonardo A.
Published: August 2023

Atmospheric escape has traditionally been observed using hydrogen Lyman-α transits, but more recent detections utilise the metastable helium triplet lines at 1083nm. Capable of being observed from the ground, this helium signature offers new possibilities for studying atmospheric escape. Such detections are dependent however on the specific high-energy flux received by the planet. Previous studies show that the extreme-UV band both drives atmospheric escape and populates the triplet state, whereas lower energy mid-UV radiation depopulates the state through photoionisations. This is supported observationally, with the majority of planets with 1083nm detections orbiting a K-type star, which emits a favourably high ratio of EUV to mid-UV flux. The goal of our work is understanding how the observability of escaping helium evolves. We couple our one-dimensional hydrodynamic non-isothermal model of atmospheric escape with a ray-tracing technique to achieve this. We consider the evolution of the stellar radiation and the planet’s gravitational potential.
Psychometric Properties of the Brazilian Portuguese Version of the Circumplex Scales of Interpersonal Problems (CSIP)
Authors: Koehler Vinícius Betzel , Boudreaux Michael J. , Tokumaru Rosana S.
Published: August 2023

Abstract. The Circumplex Scales of Interpersonal Problems (CSIP) was developed in American English to assess maladaptive variants of the interpersonal circumplex. In this article, we describe the psychometric properties and construct validity of a Brazilian Portuguese version of the CSIP using data from two samples of Brazilian adults. The results from exploratory and confirmatory structural analyses indicated strong support for a circumplex representation of the CSIP in both samples. Scores on the CSIP converged with the Brazilian Portuguese version of the Checklist of Interpersonal Transactions – Revised and demonstrated test–retest stability over 8 months. Taken as a whole, the results extend support for the circumplex structure, construct validity, and retest reliability of the CSIP and indicate that the Brazilian Portuguese translation is psychometrically adequate to investigate interpersonal problems in Brazilian populations.
Operando neutron diffraction reveals mechanisms for controlled strain evolution in 3D printing
Authors: Plotkowski A. , Saleeby K. , Fancher C. M. , Haley J. , Madireddy G. , An K. , Kannan R. , Feldhausen T. , Lee Y. , Yu D. , Leach C. , Vaughan J. , Babu S. S.
Published: August 2023

Residual stresses affect the performance and reliability of most manufactured goods and are prevalent in casting, welding, and additive manufacturing (AM, 3D printing). Residual stresses are associated with plastic strain gradients accrued due to transient thermal stress. Complex thermal conditions in AM produce similarly complex residual stress patterns. However, measuring real-time effects of processing on stress evolution is not possible with conventional techniques. Here we use operando neutron diffraction to characterize transient phase transformations and lattice strain evolution during AM of a low-temperature transformation steel. Combining diffraction, infrared and simulation data reveals that elastic and plastic strain distributions are controlled by motion of the face-centered cubic and body-centered cubic phase boundary. Our results provide a new pathway to design residual stress states and property distributions within additively manufactured components. These findings will enable control of residual stress distributions for advantages such as improved fatigue life or resistance to stress-corrosion cracking.
Ionic liquid gating induced self-intercalation of transition metal chalcogenides
Authors: Wang Fei , Zhang Yang , Wang Zhijie , Zhang Haoxiong , Wu Xi , Bao Changhua , Li Jia , Yu Pu , Zhou Shuyun
Published: August 2023

Ionic liquids provide versatile pathways for controlling the structures and properties of quantum materials. Previous studies have reported electrostatic gating of nanometer-thick flakes leading to emergent superconductivity, insertion or extraction of protons and oxygen ions in perovskite oxide films enabling the control of different phases and material properties, and intercalation of large-sized organic cations into layered crystals giving access to tailored superconductivity. Here, we report an ionic-liquid gating method to form three-dimensional transition metal monochalcogenides (TMMCs) by driving the metals dissolved from layered transition metal dichalcogenides (TMDCs) into the van der Waals gap. We demonstrate the successful self-intercalation of PdTe2 and NiTe2, turning them into high-quality PdTe and NiTe single crystals, respectively. Moreover, the monochalcogenides exhibit distinctive properties from dichalcogenides. For instance, the self-intercalation of PdTe2 leads to the emergence of superconductivity in PdTe. Our work provides a synthesis pathway for TMMCs by means of ionic liquid gating driven self-intercalation.