bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients
Authors: Ambrożewicz Ewa , Wójcik Piotr , Wroński Adam , Łuczaj Wojciech , Jastrząb Anna , Žarković Neven , Skrzydlewska Elżbieta
Published: October 2018

Inflammatory granulocytes are characterized by an oxidative burst, which may promote oxidative stress and lipid modification both in affected tissues and on a systemic level. On the other hand, redox signaling involving lipid peroxidation products acting as second messengers of free radicals play important yet not fully understood roles in the pathophysiology of inflammation and various stress-associated disorders. Therefore, the aim of this study was to evaluate the onset of oxidative stress and alterations of enzyme-dependent lipid metabolism resulting from redox imbalance in granulocytes and plasma obtained from patients with psoriasis vulgaris or psoriatic arthritis in comparison to the healthy subjects. The results obtained revealed enhanced activity of pro-oxidant enzymes nicotinamide adenine dinucleotide phosphate (NADPH) and xanthine oxidases in granulocytes with a decrease of enzymatic and non-enzymatic antioxidants in the plasma of psoriatic patients. The nuclear factor erythroid 2–related factor 2 (Nrf2) and its regulators were increased in both forms of psoriasis while heme oxygenase 1 levels were increased only in psoriasis vulgaris. The redox imbalance was associated with decreased levels of phospholipids and of free polyunsaturated fatty acids but with enhanced activity of enzymes involved in lipid metabolism (phospholipase A2, acetylhydrolase PAF, cyclooxygenases 1 and 2) and increased lipid peroxidation products 4-hydroxynonenal, isoprostanes, and neuroprostanes. Increased endocannabinoids and G protein-coupled receptor 55 were observed in both forms of the disease while expression of the cannabinoid type 1 receptor (CB1) was increased only in patients with psoriatic arthritis, which is opposite to the cannabinoid type 2 receptor. This receptor was increased only in psoriasis vulgaris. Changes in protein expression promoted the apoptosis of granulocytes by increased caspases mainly in psoriasis vulgaris. This study indicates that inhibition of the Nrf2 pathway in psoriatic arthritis promotes a redox imbalance. In addition, increased expression of CB1 receptors leads to increased oxidative stress, lipid modifications, and inflammation, which, in turn, may promote the progression of psoriasis into the advanced, arthritic form of the disease.
Preparation of Nano-Hydroxyapatite Coated Carbon Nanotube Reinforced Hydroxyapatite Composites
Authors: Zhao Xueni , Chen Xueyan , Zhang Li , Liu Qingyao , Wang Yao , Zhang Weigang , Zheng Jiamei
Published: October 2018

Uniform and dense nano-hydroxyapatite (nHA) coating with nanorod-shaped structure was fabricated on carbon nanotubes (CNTs) by combining electrodeposition with biomineralization. The CNTs with nHA coating (nHA–CNTs) were used as reinforcement to improve the mechanical properties of HA. Firstly, a mixed acid solution of nitric acid and sulfuric acid was used to treat CNTs (NS–CNTs). The dispersion of NS–CNTs was obviously improved, and O-containing functional groups were grafted on the surfaces of NS–CNTs by treatment. Then, calcium phosphate (CaP) was deposited on NS–CNTs by electrodeposition, and NS–CNTs were provided with numerous active nucleation sites for the next coating preparation process. Then nanorod-shaped HA crystals were obtained on the surfaces of NS–CNTs by biomineralization. Using the CNTs with nHA coating (nHA–CNTs) as reinforcement, HA-based composites reinforced with CNTs and nHA–CNTs (nHA–CNTs/HA) were fabricated by pressure-less process. Bending strength and fracture toughness of 1.0 wt % nHA–CNTs reinforced HA composites (HAnC1) reaches a maximum (30.77 MPa and 2.59 MPa), which increased by 26.94% and 7.02% compared with 1.0 wt % CNTs reinforced HA composites, respectively. Importantly, the fracture toughness of HAnC1 is within the range of that to compact bone. This work provides theoretical and practical guidance for preparing nHA coating on nanomaterials. It also contributes to the potential application of nHA–CNTs/HA composites for artificial bone implants.
Restoring Large Defect of Posterior Tooth by Indirect Composite Technique: A Case Report
Authors: Lu Pei-Ying , Chiang Yu-Chih
Published: October 2018

Advances in adhesive dentistry have led to increased use of indirect restorations. In some situations, indirect composite techniques are more advantageous than direct composite filling techniques, such as establishing proper occlusal and interproximal anatomy, reducing polymerization shrinkage stress, and promoting the degree of conversion. This article presents a case about restoring the lower right first molar with extensive loss of tooth structure by the composite onlay to achieve a proper anatomic form and rehabilitate chewing function. This one-year clinical case encourages clinicians to manage large decay of posterior tooth conservatively. The given functional and esthetic outcomes demonstrate the promising applicability of the indirect composite technique.
Examining the Effect of Radiant Exposure on Commercial Photopolimerizable Dental Resin Composites
Authors: Cuevas-Suárez Carlos Enrique , Pimentel-García Belinda , Rivera-Gonzaga Alejandro , Álvarez-Gayosso Carlos , Ancona-Meza Adriana Leticia , Grazioli Guillermo , Zamarripa-Calderón Eliezer
Published: October 2018

The objective of this study was to evaluate the effect of radiant exposure on the chemical and physical properties of four commercial dental resin composites. The four dental resin composites used were Kalore, Admira, Tetric N-Ceram Bulk Fill, and Filtek Z350 XT. The composites were subjected to three curing protocols: 1000 mW/cm2 for 5 s, 1000 mW/cm2 for 10 s, and 400 mW/cm2 for 25 s. The flexural strength, elastic modulus, water sorption, water solubility, degree of conversion, and polymerization shrinkage were evaluated. The results were analyzed by means of ANOVA and Tukey tests. For Admira and Kalore, significant differences between light exposure protocols were observed for the elastic modulus (p < 0.001), which was higher when a higher amount of radiant exposure was used. For Filtek Z350, differences were only observed for the degree of conversion (p < 0.001), and a higher amount of radiant exposure allowed us to obtain higher values. The Tetric N-Ceram Bulk Fill analysis showed significant differences for the elastic modulus and water sorption (p < 0.001), and specimens that had been subject to a radiant exposure of 10 J/cm2 showed a higher elastic modulus. In most cases, the physical and mechanical properties analyzed were not affected by different radiant exposure values. Other resin-based composite (RBC) characteristics seem to have a greater influence on material properties.
Early Life Professional and Layperson Support Reduce Poor Oral Hygiene Habits in Toddlers—A Prospective Birth Cohort Study
Authors: Ha Diep Hong , Do Loc Giang
Published: October 2018

Oral health behaviours of children are formulated from a very young age. Formation of those behaviours among very young children is dependent on their mothers/caregivers who may themselves require support from the health profession or laypersons. The study aimed to investigate if early life visits for check-up and dental advice and perceived support improved oral health behaviours as practiced by mothers of toddlers aged 24–30 months old. Data from a population-base birth cohort study in South Australia was used. The study recruited and followed mothers of newborn children from birth to age 24–30 months. Parental questionnaires collected information about socioeconomic factors, dental visiting patterns, and oral health behaviours as practiced by the mothers for their child. Self-reported putting a child to bed with a bottle and brushing a child’s teeth were the outcome variables. The two main exposures of this study were (1) early visiting for a dental advice, and (2) layperson support that a mother received in the first two years of having the child. Data were analysed progressively from bivariate to multivariable regression models. A total of 1183 mother/child dyads had complete data. The retained sample was representative of the population. Approximately 36% of mothers put their child to bed with a bottle and 26% of mothers did not brush their child’s teeth the night before. Around 29% of children had a visit for dental check-up and 80% of mothers reported having lay support. There were gradients in the outcome variables by socioeconomic factors and the main exposures. Multivariable regression models reported that having no dental visit for advice and having no lay support were associated with 1.30 and 1.21 imes higher rates of putting a child to bed with a bottle, respectively. Having no dental visit for advice was associated with a 1.37-times higher rate of not brushing a child’s teeth, controlling for other factors. This population-based birth cohort study confirmed importance of early life dental visit for check-up and support for mothers of young children in establishing oral health behaviours of young children.
What Biological Visualizations Do Science Center Visitors Prefer in an Interactive Touch Table?
Authors: Höst Gunnar E. , Schönborn Konrad J. , Fröcklin Henry , Tibell Lena A. E.
Published: October 2018

Hands-on digital interactivity in science centers provides new communicative opportunities. The Microcosmos multi-touch table allows visitors to interact with 64 image “cards” of (sub)microscopic biological structures and processes embedded across seven theme categories. This study presents the integration of biological content, interactive features and logging capabilities into the table, and analyses visitors’ usage and preferences. Data logging recorded 2,070,350 events including activated category, selected card, and various finger-based gestures. Visitors interacted with all cards during 858 sessions (96 s on average). Finger movements covered an average accumulated distance of 4.6 m per session, and about 56% of card interactions involved two fingers. Visitors made 5.53 category switches per session on average, and the virus category was most activated (average 0.96 per session). An overall ranking score related to card attractive power and holding power revealed that six of the most highly used cards depicted viruses and four were colourful instrument output images. The large finger traversal distance and proportion of two-finger card interaction may indicate the intuitiveness of the gestures. Observed trends in visitor engagement with the biological visualizations are considered in terms of construal level theory. Future work will examine how interactions are related to potential learning of biological content.
SHIL and DHIL Simulations of Nonlinear Control Methods Applied for Power Converters Using Embedded Systems
Authors: Rosa Arthur H. R. , Silva Matheus B. E. , Campos Marcos F. C. , Santana Renato A. S. , Rodrigues Welbert A. , Morais Lenin M. F. , Jr. Seleme I. Seleme
Published: October 2018

In this work, a new real-time Simulation method is designed for nonlinear control techniques applied to power converters. We propose two different implementations: in the first one (Single Hardware in The Loop: SHIL), both model and control laws are inserted in the same Digital Signal Processor (DSP), and in the second approach (Double Hardware in The Loop: DHIL), the equations are loaded in different embedded systems. With this methodology, linear and nonlinear control techniques can be designed and compared in a quick and cheap real-time realization of the proposed systems, ideal for both students and engineers who are interested in learning and validating converters performance. The methodology can be applied to buck, boost, buck-boost, flyback, SEPIC and 3-phase AC-DC boost converters showing that the new and high performance embedded systems can evaluate distinct nonlinear controllers. The approach is done using matlab-simulink over commodity Texas Instruments Digital Signal Processors (TI-DSPs). The main purpose is to demonstrate the feasibility of proposed real-time implementations without using expensive HIL systems such as Opal-RT and Typhoon-HL.
Simple Torque Control Method for Hybrid Stepper Motors Implemented in FPGA
Authors: Ricci Stefano , Meacci Valentino
Published: October 2018

Stepper motors are employed in a wide range of consumer and industrial applications. Their use is simple: a digital device generates pulse-bursts and a direction bit towards a power driver that produces the 2-phase currents feeding the motor windings. Despite its simplicity, this open-loop approach fails if the torque load exceeds the motor capacity, so the motor and driver should be oversized at the expense of efficiency and cost. Field-Oriented closed-loop Control (FOC) solves the problem, and the recent availability of low cost electronics devices like Digital Signal Processors, Field Programmable Gate Arrays (FPGA), or even Microcontrollers with dedicated peripherals, fostered the investigation and implementation of several variants of the FOC method. In this paper, a simple and economic FOC torque control method for hybrid stepper motors is presented. The load angle is corrected accordingly to the actual shaft position through pulse-bursts and direction commands issued towards a commercial stepper driver, which manages the 2-phase winding currents. Thanks to the FPGA implementation, the control loop updates the electrical position every 50 μs only, thus allowing a load angle accuracy of −1/100 rad for a rotor velocity up to 750 rev/min, as shown in the reported experiments.
Exploring the Interplay between CAD and FreeFem++ as an Energy Decision-Making Tool for Architectural Design
Authors: Rojas-Fernández Juan , Galán-Marín Carmen , Rivera-Gómez Carlos , Fernández-Nieto Enrique D.
Published: October 2018

The energy modelling software tools commonly used for architectural purposes do not allow a straightforward real-time implementation within the architectural design programs. In addition, the surrounding exterior spaces of the building, including the inner courtyards, hardly present a specific treatment distinguishing these spaces from the general external temperature in the thermal simulations. This is a clear disadvantage when it comes to streamlining the design process in relation to the whole-building energy optimization. In this context, the present study aims to demonstrate the advantages of the FreeFem++ open source program for performing simulations in architectural environments. These simulations include microclimate tests that describe the interactions between a building architecture and its local exterior. The great potential of this mathematical tool can be realized through its complete system integration within CAD (Computer-Aided Design) software such as SketchUp or AutoCAD. In order to establish the suitability of FreeFem++ for the performance of simulations, the most widely employed energy simulation tools able to consider a proposed architectural geometry in a specific environment are compared. On the basis of this analysis, it can be concluded that FreeFem++ is the only program displaying the best features for the thermal performance simulation of these specific outdoor spaces, excluding the currently unavailable easy interaction with architectural drawing programs. The main contribution of this research is, in fact, the enhancement of FreeFem++ usability by proposing a simple intuitive method for the creation of building geometries and their respective meshing (pre-processing). FreeFem++ is also considered a tool for data analysis (post-processing) able to help engineers and architects with building energy-efficiency-related tasks.
Carbon Dioxide Emissions, Energy Consumption and Economic Growth: A Comparative Empirical Study of Selected Developed and Developing Countries. “The Role of Exergy”
Authors: Arango-Miranda Raúl , Hausler Robert , Romero-Lopez Rabindranarth , Glaus Mathias , Ibarra-Zavaleta Sara P.
Published: October 2018

Diverse factors may have an impact in carbon dioxide (CO2) emissions; thus, three main contributors, energy consumption, gross domestic product (GDP) and an exergy indicator are examined in this work. This study explores the relationship between economic growth and energy consumption by means of the hypothesis postulated for the Environmental Kuznets Curve (EKC). Panel data for ten countries, from 1971 to 2014 have been studied. Despite a wide gamma of research on the EKC, the role of an exergy variable has not been tested to find the EKC; for this reason, exergy analysis is proposed. Exergy analyses were performed to propose an exergetic indicator as a control variable and a comparative empirical study is developed to study a multivariable framework with the aim to detect correlations between them. High correlation between CO2, GDP, energy consumption, energy intensity and trade openness are observed, on the other hand not statistically significant values for trade openness and energy intensity. The results do not support the EKC hypothesis, however exergy intensity opens the door for future research once it proves to be a useful control variable. Exergy provides opportunities to analyze and implement energy and environmental policies in these countries, with the possibility to link exergy efficiencies and the use of renewables.
Numerical Investigation of the Chemical Effect and Inhibition Effect Improvement of C3H2F3Br (2-BTP) Using the Perfectly Stirred Reactor Model
Authors: Li Ping , Ke Bo , Zhang Jian , Chen Xianfeng
Published: October 2018

The overall chemical rate and chemical effect of CF3Br, 2-BTP and 2-BTP/CO2 with hydrocarbon flames are calculated using the perfectly stirred reactor (PSR) model. The chemical effects of CF3Br with CH4/air flames always inhibit combustion. The chemical saturation concentration of CF3Br in stoichiometric and lean (Φ = 0.6) CH4/air flames at 298 K and 1 bar is roughly 2.5% and 0.8%, respectively. The overall chemical rate of 2-BTP with moist C3H8/air flames is always less than the uninhibited condition and fluctuates with sub-inerting agent additions. The net chemical effect variation of 2-BTP is more complicated than experimented and calculated flame speeds with 2-BTP added to lean hydrocarbon flames. There are negative chemical effects (chemical combustion effects) with certain sub-inerting 2-BTP concentrations (0.015 ≤ Xa ≤ 0.034), which result in the experimented unwanted combustion enhancement in lean moist C3H8/air flames. CO2 can obviously improve the inhibition effect of 2-BTP in lean moist C3H8/air flames, driving negative chemical effects (enhance combustion) into positive chemical effects (inhibit combustion) with lean moist C3H8/air flames. No enhanced combustion would occur with the blends (2-BTP/CO2) when CO2 addition is larger than 4% in Φ = 0.6 moist C3H8/air flames at 298 K and 1 bar.
Ecotoxicity of In-Situ Produced Compost Intended for Landfill Restoration
Authors: Vaverková Magdalena Daria , Adamcová Dana , Radziemska Maja , Zloch Jan , Brtnický Martin , Šindelář Ondřej , Maxiánová Alžbeta , Mazur Zbigniew
Published: October 2018

Municipal solid waste (MSW) has become a matter of increasing global concern. Biological conversion is considered to be the most applicable disposal method, especially for the organic fraction of MSW. The aim of this study was to evaluate composting as a treatment method for the sustainable management and recycling of MSW and to test the ecotoxicity of the compost produced on the landfill surface. The ecotoxicity of the compost was investigated by means of a set of biological tests. The ecotoxicological impact of the compost was evaluated by plant growth tests with white mustard (Sinapis alba L.) and barley (Hordeum vulgare L.). Plants were grown under controlled conditions for 21 days, in earthen pots, treated with MSW compost (MSWC) to study the effect of MSWC on plant biomass production. Sprouts and the number of growing plants occurring in the earthen pots were counted. The values obtained from three simultaneously conducted experiments were averaged and presented. Plants growing in the earthen pots with the compost exhibited increasing plant biomass while no changes were observed in their appearance; retarded growth or necrotic changes were not recorded. The ecotoxicity tests performed show that the analyzed compost produced in the composting plant situated on the landfill surface achieved high percentages of the germinating capacity of white mustard (Sinapis alba L.) and barley (Hordeum vulgare L.) seeds and can be therefore used in the subsequent reclamation of the landfill concerned.
How to Bloom the Green Desert: Eucalyptus Plantations and Native Forests in Uruguay beyond Black and White Perspectives
Authors: Pozo Paola , Säumel Ina
Published: October 2018

The ongoing debate on the boon or bane of monocultural timber plantations demonstrates the need to develop alternative approaches that achieve forest productivity while conserving biodiversity. We assessed the diversity of tree species in native forests and in Eucalyptus plantations, and evaluated the potential use of native species to enhance plantation management. For this purpose, we established one-hectare permanent plots in nine native forests (riverine and park forests) and nine Eucalyptus plantations in the northwestern part of Uruguay. Forest inventories were carried out on 200 m2 plots and regeneration was assessed along transects in 9 m2 subplots. Riverine forests have the highest Shannon diversity index (2.5) followed by park forests (2.1) and Eucalyptus plantations (1.3). Tree density was high in riverine forests (1913/ha) and plantations (1315/ha), whereas park forests have lower tree density (796/ha). Regeneration density was high in riverine forests (39136/ha) and park forests (7500/ha); however, native species can regenerate in the understory of plantations (727/ha), and this underlines the possibility of developing a mixed species approach to reduce the negative impact of monocultures. Differences in the composition of plant communities were denoted between native forests and plantations, although native forests were similar in composition, even in the presence of exotic species. Native forests harbor specialist species that are absent from plantations, and therefore perform a decisive role in maintaining local biodiversity. Strategies to enhance species diversity and structural diversity within plantations or to establish mixed buffer strips containing native species at the edge of plantations are potential measures to enhance biodiversity and foster the integration of plantations into the local landscape.
Highly Thiolated Poly (Beta-Amino Ester) Nanoparticles for Acute Redox Applications
Authors: Lakes Andrew L. , Puleo David A. , Hilt J. Zach , Dziubla Thomas D.
Published: October 2018

Disulfides are used extensively in reversible cross-linking because of the ease of reduction into click-reactive thiols. However, the free-radical scavenging properties upon reduction are often under-considered. The free thiols produced upon reduction of this disulfide material mimic the cellular reducing chemistry (glutathione) that serves as a buffer against acute oxidative stress. A nanoparticle formulation producing biologically relevant concentrations of thiols may not only provide ample chemical conjugation sites, but potentially be useful against severe acute oxidative stress exposure, such as in targeted radioprotection. In this work, we describe the synthesis and characterization of highly thiolated poly (β-amino ester) (PBAE) nanoparticles formed from the reduction of bulk disulfide cross-linked PBAE hydrogels. Degradation-tunable PBAE hydrogels were initially synthesized containing up to 26 wt % cystamine, which were reduced into soluble thiolated oligomers and formulated into nanoparticles upon single emulsion. These thiolated nanoparticles were size-stable in phosphate buffered saline consisting of up to 11.0 ± 1.1 mM (3.7 ± 0.3 mmol thiol/g, n = 3 M ± SD), which is an antioxidant concentration within the order of magnitude of cellular glutathione (1–10 mM).
Cryostructuring of Polymeric Systems. 49. Unexpected “Kosmotropic-Like” Impact of Organic Chaotropes on Freeze–Thaw-Induced Gelation of PVA in DMSO
Authors: Lozinsky Vladimir I. , Kolosova Olga Yu. , Michurov Dmitrii A. , Dubovik Alexander S. , Vasil’ev Viktor G. , Grinberg Valerij Ya.
Published: October 2018

Urea (URE) and guanidine hydrochloride (GHC) possessing strong chaotropic properties in aqueous media were added to DMSO solutions of poly(vinyl alcohol) (PVA) to be gelled via freeze–thaw processing. Unexpectedly, it turned out that in the case of the PVA cryotropic gel formation in DMSO medium, the URE and GHC additives caused the opposite effects to those observed in water, i.e., the formation of the PVA cryogels (PVACGs) was strengthened rather than inhibited. Our studies of this phenomenon showed that such “kosmotropic-like” effects were more pronounced for the PVACGs that were formed in DMSO in the presence of URE additives, with the effects being concentration-dependent. The additives also caused significant changes in the macroporous morphology of the cryogels; the commonly observed trend was a decrease in the structural regularity of the additive-containing samples compared to the additive-free gel sample. The viscosity measurements revealed consistent changes in the intrinsic viscosity, Huggins constant, and the excess activation heat of the viscosity caused by the additives. The results obtained evidently point to the urea-induced decrease in the solvation ability of DMSO with respect to PVA. As a result, this effect can be the key factor that is responsible for strengthening the structure formation upon the freeze–thaw gelation of this polymer in DMSO additionally containing additives such as urea, which is capable of competing with PVA for the solvent.
Exploring the Emerging Evolution Trends of Urban Resilience Research by Scientometric Analysis
Authors: Wang Liang , Xue Xiaolong , Zhang Yuanxin , Luo Xiaowei
Published: October 2018

Numerous studies in urban resilience have been published in the past decade. However, only a few publications have tracked the evolution trends of urban resilience research, the findings of which can serve as a useful guide for scholars to foresee worth-effort research areas and make the best use of precious time and resources. In order to fill the research gap, this study performed a scientometric analysis on the evolution trends of urban resilience research using a versatile software package-CiteSpace. The scientomentric analysis focuses on distribution of lead authors and their institutions, high frequency categories and keywords, high influential journals, author contribution, and evolutionary trends based on co-author analysis, co-word analysis, co-citation analysis and cluster analysis of documents. This study discoveries that first, the U.S., England, Australia, Canada, China and Sweden are the countries that make the most significant contributions in the advancement of urban resilience research; second, the existing urban resilience research focuses primarily on environmental studies, geography and planning development; third, hot topics of the urban resilience research keep shifting from 1993 to 2016; fourth, the knowledge body of urban resilience research consists of five clusters: resilience exploratory analysis, disaster resilience, urban resilience, urban resilience practice, and social-ecological systems; last, the emerging trends in urban resilience research include defining urban resilience, adaptation model, case studies, analytical methods and urban social-ecological systems, resulting in cutting-edge research areas in urban resilience.
Protected Natural Areas: In Sickness and in Health
Authors: Romanillos Teresa , Maneja Roser , Varga Diego , Badiella Llorenç , Boada Martí
Published: October 2018

Numerous studies show the benefits that contact with the natural environment have for human health, but there are few studies on the role of Protected Natural Areas (PNAs), either from the preventive point of view or on their potential benefits, on individuals with health problems. A study was made of the relationship between the visitation of Montseny Natural Park and Biosphere Reserve and health, from the perspective of a population group with different diseases. A total of 250 patients resident in the areas near the park were surveyed, recording their beliefs about the benefits of nature, as well as the reasons for visiting and the activities associated with health that they carried out in the park. The pure air is the most valued benefit (27.2%), particularly for those with allergies. The majority (57%) visit the park for health reasons. High levels (82%) of exercise are recorded, especially by patients with heart diseases (85%), and 65% exercised in the park. More physical activity is mentioned among those that visit the park most often, particularly among those that carried it out for health reasons. Plants were collected for medicinal use by 39.6%. The study confirmed the significant role of the Montseny Natural Park and Biosphere Reserve as a health resource for individuals with diseases that live near it. It also corroborates the beneficial effects that the PNA provide in human health.
Misperception of Oral Health among Adults in Rural Areas: A Fundamental but Neglected Issue in Primary Healthcare
Authors: Chen Mei-Yen
Published: October 2018

Background: Poor oral hygiene is associated with metabolic syndrome, systemic diseases, mortality and many chronic diseases. Misperception means a wrong or incorrect understanding or interpretation. Few studies have examined the subjective perception and objective condition of oral health among community adults in rural areas. Methods: This was a cross-sectional, community-based study. Participants were recruited via convenience samples from December 2015 to July 2016. One thousand six (1006) community residents participated in the project, of which 973 fulfilled the inclusion criteria. The average age was 42.8 (SD = 12.3) years, range 20–64, selected from a collaboration local hospital. Results: Most of the participants reported brushing their teeth every day, however, 72% reported seldom brushing their teeth after meals, 54% seldom used dental floss, 64% seldom received dental scaling, 29.5% had experienced a toothache within 6 months, and 30.5% demonstrated significant tooth loss. However, most of them perceived their oral health as good. Misperception of oral health was common, 21.5% among whose number of remaining teeth <25 under-assess their actual oral health. The more number of remaining teeth (p < 0.001) and regular dental check-up (p < 0.01) were positively associated with feeling good about their oral health. After adjusting for potential confounders, clinically significant findings indicated that number of remaining teeth (OR = 3.03, p < 0.001), age (OR = 0.99, p < 0.001), regular dental check-ups/scaling (OR = 1.85, p < 0.001), education (OR = 1.45, p < 0.05), and water consumption (OR = 1.38, p < 0.05) were independently associated with good perceived oral health. Conclusions: The findings showed that subjective self-perception of oral health was not matched with their objective oral condition. Excluding the unmodifiable factors, the clinical implications indicated that oral health promotion programs, particularly for adopting regular dental check-up, healthy diet and oral hygiene habits are urgent in rural areas.
The Issue of Burnout and Work Satisfaction in Younger GPs—A Cluster Analysis Utilizing the HaMEdSi Study
Authors: Hirsch Oliver , Adarkwah Charles Christian
Published: October 2018

The shortage of general practitioners (GPs) in Germany has become a relevant problem. Therefore, it is important to find the determinants that make primary care more attractive, and which support GPs remaining in practice. Our aim in this exploratory study was to search for relevant GP subgroups and their characteristics in order to find starting points for improvements or interventions. We attempted a comprehensive survey of all GPs in the German region of Siegen-Wittgenstein with about 280,000 inhabitants. There were 158 GPs in the total population; 85 of these (53.8%) took part in the study. There were 64 male GPs (75.3%) in our sample. The mean age of the participants was 53.5 years (SD 8.93). The questionnaire was composed of demographic questions, questions regarding future perspectives, the Motivation for Medical Education Questionnaire (MoME-Q), the Maslach Burnout Inventory (MBI), and the Work Satisfaction Questionnaire. K-means cluster analyses were used for subgrouping. A 2-cluster solution had good statistical quality criteria. Cluster 1 was characterised by elderly GPs who more frequently had a resident physician in their practices. These GPs had low burnout scores and high work satisfaction scores. Cluster 2 consisted of younger GPs who less frequently had a resident in their practices. They had average burnout scores according to published norms and lower work satisfaction scores. There seems to be an age cohort effect regarding burnout and work satisfaction. Having a resident physician seems to be protective. Interventions should be designed for younger GPs, especially members of generation Y, to reduce burnout and improve work satisfaction.
A Comprehensive Review of Arsenic Exposure and Risk from Rice and a Risk Assessment among a Cohort of Adolescents in Kunming, China
Authors: Liao Noelle , Seto Edmund , Eskenazi Brenda , Wang May , Li Yan , Hua Jenna
Published: October 2018

Inorganic arsenic (iAs) is carcinogenic and highly concentrated in rice. Dietary exposure to iAs is concerning among adolescents due to their developmental stage and iAs’s long-latency effects. This paper aimed to assess iAs exposure from rice and related lifetime cancer risks (LCR) among adolescents in Kunming, China. A comprehensive literature review of iAs levels in rice and LCR in humans was also conducted. Average daily consumption of rice (ADC) was estimated from 267 adolescents (15–18 years). Rice samples obtained from 6 markets were analyzed for iAs concentration (AC). Estimated daily intake (EDI) of iAs was calculated using ADC, AC, and average body weight (BW). Lifetime Cancer Risk (LCR) was calculated using EDI and U.S. EPA derived iAs oral slope factor. The AC was 0.058 mg/kg and the average BW and ADC were 67.5 kg and 410 g/day for males and 55.5 kg and 337 g/day for females. The EDI and LCR were 3.52 × 10−4 mg/kg-BW/day and 5.28 × 10−4 for both males and females, with LCR 5 times above the U.S. LCR upper limit of 1.0 × 10−4. While the AC was below the Chinese maximum contaminant level of 0.2 mg/kg, study results indicated that Kunming adolescents may be at increased risk for iAs-related cancers.
An Evolutionary Game-Theoretic Approach for Assessing Privacy Protection in mHealth Systems
Authors: Zhu Guang , Liu Hu , Feng Mining
Published: October 2018

With the rapid deployment of mobile technologies and their applications in the healthcare domain, privacy concerns have emerged as one of the most critical issues. Traditional technical and organizational approaches used to address privacy issues ignore economic factors, which are increasingly important in the investment strategy of those responsible for ensuring privacy protection. Taking the mHealth system as the context, this article builds an evolutionary game to model three types of entities (including system providers, hospitals and governments) under the conditions of incomplete information and bounded rationality. Given that the various participating entities are often unable to accurately estimate their own profits or costs, we propose a quantified approach to analyzing the optimal strategy of privacy investment and regulation. Numerical examples are provided for illustration and simulation purpose. Based upon these examples, several countermeasures and suggestions for privacy protection are proposed. Our analytical results show that governmental regulation and auditing has a significant impact on the strategic choice of the other two entities involved. In addition, the strategic choices of system providers and hospitals are not only correlated with profits and investment costs, but they are also significantly affected by free riding. If the profit growth coefficients increase to a critical level, mHealth system providers and hospitals will invest in privacy protection even without the imposition of regulations. However, the critical level is dependent on the values of the parameters (variables) in each case of investment and profits.
High-Performance Geospatial Big Data Processing System Based on MapReduce
Authors: Jo Junghee , Lee Kang-Woo
Published: October 2018

With the rapid development of Internet of Things (IoT) technologies, the increasing volume and diversity of sources of geospatial big data have created challenges in storing, managing, and processing data. In addition to the general characteristics of big data, the unique properties of spatial data make the handling of geospatial big data even more complicated. To facilitate users implementing geospatial big data applications in a MapReduce framework, several big data processing systems have extended the original Hadoop to support spatial properties. Most of those platforms, however, have included spatial functionalities by embedding them as a form of plug-in. Although offering a convenient way to add new features to an existing system, the plug-in has several limitations. In particular, while executing spatial and nonspatial operations by alternating between the existing system and the plug-in, additional read and write overheads have to be added to the workflow, significantly reducing performance efficiency. To address this issue, we have developed Marmot, a high-performance, geospatial big data processing system based on MapReduce. Marmot extends Hadoop at a low level to support seamless integration between spatial and nonspatial operations of a solid framework, allowing improved performance of geoprocessing workflow. This paper explains the overall architecture and data model of Marmot as well as the main algorithm for automatic construction of MapReduce jobs from a given spatial analysis task. To illustrate how Marmot transforms a sequence of operators for spatial analysis to map and reduce functions in a way to achieve better performance, this paper presents an example of spatial analysis retrieving the number of subway stations per city in Korea. This paper also experimentally demonstrates that Marmot generally outperforms SpatialHadoop, one of the top plug-in based spatial big data frameworks, particularly in dealing with complex and time-intensive queries involving spatial index.
Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation
Authors: Saga Kunihiro , Iwashita Yukio , Hidano Shinya , Aso Yuiko , Isaka Kenji , Kido Yasutoshi , Tada Kazuhiro , Takayama Hiroomi , Masuda Takashi , Hirashita Teijiro , Endo Yuichi , Ohta Masayuki , Kobayashi Takashi , Inomata Masafumi
Published: October 2018

Hepatic stellate cells (HSCs) are key players in liver fibrosis, cellular senescence, and hepatic carcinogenesis. Bile acids (BAs) are involved in the activation of HSCs, but the detailed mechanism of this process remains unclear. We conducted a comprehensive DNA microarray study of the human HSC line LX-2 treated with deoxycholic acid (DCA), a secondary unconjugated BA. Additionally, LX-2 cells were exposed to nine BAs and studied using immunofluorescence staining, enzyme-linked immunosorbent assay, and flow cytometry to examine the mechanisms of HSC activation. We focused on the tumor necrosis factor (TNF) pathway and revealed upregulation of genes related to nuclear factor kappa B (NF-κB) signaling and senescence-associated secretory phenotype factors. α-Smooth muscle actin (α-SMA) was highly expressed in cells treated with secondary unconjugated BAs, including DCA, and a morphological change associated with radial extension of subendothelial protrusion was observed. Interleukin-6 level in culture supernatant was significantly higher in cells treated with secondary unconjugated BAs. Flow cytometry showed that the proportion of cells highly expressing α-SMA was significantly increased in HSCs cultured with secondary unconjugated BAs. We demonstrated that secondary unconjugated BAs induced the activation of human HSCs.
Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity
Authors: Terry Stéphane , Faouzi Zaarour Rania , Hassan Venkatesh Goutham , Francis Amirtharaj , El-Sayed Walid , Buart Stéphanie , Bravo Pamela , Thiery Jérome , Chouaib Salem
Published: October 2018

Hypoxia, or gradients of hypoxia, occurs in most growing solid tumors and may result in pleotropic effects contributing significantly to tumor aggressiveness and therapy resistance. Indeed, the generated hypoxic stress has a strong impact on tumor cell biology. For example, it may contribute to increasing tumor heterogeneity, help cells gain new functional properties and/or select certain cell subpopulations, facilitating the emergence of therapeutic resistant cancer clones, including cancer stem cells coincident with tumor relapse and progression. It controls tumor immunogenicity, immune plasticity, and promotes the differentiation and expansion of immune-suppressive stromal cells. In this context, manipulation of the hypoxic microenvironment may be considered for preventing or reverting the malignant transformation. Here, we review the current knowledge on how hypoxic stress in tumor microenvironments impacts on tumor heterogeneity, plasticity and resistance, with a special interest in the impact on immune resistance and tumor immunogenicity.
Elastic Properties of Magnetorheological Elastomers in a Heterogeneous Uniaxial Magnetic Field
Authors: Kikuchi Takehito , Kobayashi Yusuke , Kawai Mika , Mitsumata Tetsu
Published: October 2018

Magnetorheological elastomers (MREs) are stimulus-responsive soft materials that consist of polymeric matrices and magnetic particles. In this study, large-strain response of MREs with 5 vol % of carbonyl iron (CI) particles is experimentally characterized for two different conditions: (1) shear deformation in a uniform magnetic field; and (2), compression in a heterogeneous uniaxial magnetic field. For condition (1), dynamic viscoelastic measurements were performed using a rheometer with a rotor disc and an electric magnet that generated a uniform magnetic field on disc-like material samples. For condition (2), on the other hand, three permanent magnets with different surface flux densities were used to generate a heterogeneous uniaxial magnetic field under cylindrical material samples. The experimental results were mathematically modeled, and the relationship between them was investigated. We also used finite-element method (FEM) software to estimate the uniaxial distributions of the magnetic field in the analyzed MREs for condition (2), and developed mathematical models to describe these phenomena. By using these practicable techniques, we established a simple macroscale model of the elastic properties of MREs under simple compression. We estimated the elastic properties of MREs in the small-strain regime (neo–Hookean model) and in the large-strain regime (Mooney–Rivlin model). The small-strain model explains the experimental results for strains under 5%. On the other hand, the large-strain model explains the experimental results for strains above 10%.
Evaluation of Circulating MicroRNA Biomarkers in the Acute Pancreatic Injury Dog Model
Authors: Lee Han-Byul , Park Hyun-Kyu , Choi Hyun-Ji , Lee Sora , Lee Sang-Joon , Lee Ji-Young , Cho Eun-Ho , Han Hyo-Jeong , Seok Ju-Hyung , Son Woo-Chan
Published: October 2018

This study aimed to evaluate the usefulness of four microRNAs (miRNAs) in an acute pancreatic injury dog model. Acute pancreatitis was induced by infusion of cerulein for 2 h (7.5 μg/kg/h). The levels of well-known miRNAs, microRNA-216a (miR-216a) and microRNA-375 (miR-375), and new candidates microRNA-551b (miR-551b), and microRNA-7 (miR-7), were measured at 0, 0.5, 1, 2, 6, 12, and 24 h with serum amylase and lipase, and histopathological examination was performed. Among the four miRNAs, miR-216a and miR-375, and serum enzymes were significantly increased by cerulein treatment. The expression levels of miRNAs and serum enzymes peaked at 2–6 h with a similar pattern; however, the overall increases in miR-216a and miR-375 levels were much higher than those of the serum enzyme biomarkers. Increased levels of miR-216a and miR-375 were most highly correlated to the degree of individual histopathological injuries of the pancreas, and showed much greater dynamic response than serum enzyme biomarkers. Twenty-four-hour time-course analysis in this study revealed time-dependent changes of miRNA expression levels, from initial increase to decrease by predose level in acute pancreatitis. Our findings demonstrate that, in dogs, miR-216a and miR-375 have the potential to sensitively detect pancreatitis and reflect well the degree of pancreatic injury, whereas miR-551b and miR-7 do not.
Genomic Deletion of BAP1 and CDKN2A Are Useful Markers for Quality Control of Malignant Pleural Mesothelioma (MPM) Primary Cultures
Authors: Sarun Kadir Harun , Lee Kenneth , Williams Marissa , Wright Casey Maree , Clarke Candice Julie , Cheng Ngan Ching , Takahashi Ken , Cheng Yuen Yee
Published: October 2018

Malignant pleural mesothelioma (MPM) is a deadly cancer that is caused by asbestos exposure and that has limited treatment options. The current standard of MPM diagnosis requires the testing of multiple immunohistochemical (IHC) markers on formalin-fixed paraffin-embedded tissue to differentiate MPM from other lung malignancies. To date, no single biomarker exists for definitive diagnosis of MPM due to the lack of specificity and sensitivity; therefore, there is ongoing research and development in order to identify alternative biomarkers for this purpose. In this study, we utilized primary MPM cell lines and tested the expression of clinically used biomarker panels, including CK8/18, Calretinin, CK 5/6, CD141, HBME-1, WT-1, D2-40, EMA, CEA, TAG72, BG8, CD15, TTF-1, BAP1, and Ber-Ep4. The genomic alteration of CDNK2A and BAP1 is common in MPM and has potential diagnostic value. Changes in CDKN2A and BAP1 genomic expression were confirmed in MPM samples in the current study using Fluorescence In situ Hybridization (FISH) analysis or copy number variation (CNV) analysis with digital droplet PCR (ddPCR). To determine whether MPM tissue and cell lines were comparable in terms of molecular alterations, IHC marker expression was analyzed in both sample types. The percentage of MPM biomarker levels showed variation between original tissue and matched cells established in culture. Genomic deletions of BAP1 and CDKN2A, however, showed consistent levels between the two. The data from this study suggest that genomic deletion analysis may provide more accurate biomarker options for MPM diagnosis.