bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Curcuma longa maceration treatment on ovarian follicular development, serum oestradiol, uterine growth and vascularisation in female albino rats
Authors: Andriyanto Andriyanto , Putra Hamdika Yendri , Subangkit Mawar , Tarigan Elpita , Nugrahaning Widi Leliana , Irarang Yusa , Manalu Wasmen , Fadholly Amaq
Published: April 2024

Introduction

Curcuma longa is a well-known medicinal plant with various health benefits. This study was designed to evaluate the administration of Indonesian C. longa maceration for its effect on promoting growth and development of the ovary and uterus before mating in female albino rats.

Material and Methods

A total of 15 female Sprague Dawley rats in their dioestrous phase were assigned into three different groups: the Control group (mineral water); the Cur-Low group (mineral water with 1% C. longa maceration) and the Cur-High group (mineral water with 5% C. longa maceration). The treatments were given for 20 days. Serum concentrations of follicle-stimulating hormone, oestradiol and progesterone were determined. After the sacrifice of the rats, ovary and uterine relative weight, uterine cornua diameter and length, uterine gland diameter (by histology), the number of primary, secondary, tertiary, and Graafian follicles, the number of corpora lutea and vascular endothelial growth factor (VEGF) expression in the ovary were measured. Uterine vascularisation was also evaluated.

Results

Administration of C. longa maceration significantly improved the relative weights of the uterus and ovary; uterine cornua diameter, length and vascularisation; uterine gland diameter; and expression of VEGF in the ovary. It also increased the number of tertiary follicles and corpora lutea, albeit not significantly. Follicle-stimulating hormone serum concentrations were lower in the administered rats.

Conclusion

Oestradiol and progesterone levels rose with C. longa maceration treatment. The maceration improved the reproductive organs of unmated rats and had potential to optimise the uterine environment for supporting pregnancy in order to produce high-quality offspring.
Structure, diversity, and genetic delimitation of two Magnolia species endemic to eastern Mexico
Authors: López-Ramírez Liliana , Hernández-Vera Gerardo , Galván-Hernández Dulce María , Aguilar Pablo Octavio , Carranza-Aranda Ahtziri Socorro , Vázquez-García José Antonio , Sánchez-González Arturo
Published: April 2024

In Mexico, Magnolia species of the section Macrophylla have been segregated based on phenotypic characteristics. However, the wide environmental variation throughout their distribution area in the eastern region of the country could be the main cause of the high degree of morphological variation among the taxa of this section. Therefore, it is necessary to carry out studies at the genetic level to confirm the taxonomic identity of these species. In the present study, the diversity and genetic structure of the populations of Magnolia rzedowskiana and M. zotictla were estimated using simple sequence repeat markers. We evaluated whether the taxonomic delimitation as independent species is consistent with their degree of genetic differentiation, comparing three regions of chloroplast DNA: trnH-psbA, ORF350, and rpl32-trnL. The DNA was obtained from four populations of the two species, which are distributed in the states of Hidalgo, Querétaro and San Luis Potosí. The populations presented intermediate–high genetic diversity (He = 0.52–0.60), limited gene flow (Nm = 0.62) and high genetic differentiation (Fst = 0.288), which may be related to their low density and strong geographic isolation, caused by the high degree of fragmentation of their habitat. The phylogenetic analysis and the genetic differentiation values indicate that each of the populations of the two Magnolia species analyzed behaves as an independent evolutionary unit, so the taxonomic delimitation of the three M. rzedowskiana populations must be reconsidered. The results obtained could be very useful for implementing management and conservation strategies for these populations in the short term.
Postmodernism Paradigm and its View on the Existence of Language
Authors: Sudartini Siti
Published: April 2024

Objective: The emergence of postmodernism as a continuation and correction of the shortcomings of modernism is expected to provide new alternatives and complement the repertoire of human thinking, especially about the existence of language and culture. Although, in principle, all paradigms of thinking have their own advantages and disadvantages. This paper aims to examine the issues surrounding the postmodernism paradigm, which is focused on two main things, namely: the concept and basic principles of the paradigm and the view of the postmodern paradigm in relation to the existence of language phenomena.
 
Method: Methodologically, this article is based on a literature study, which is conducted by identifying various theories related to postmodernism, to answer the problems that have been raised.
 
Results and Discussion: From the results of this study, the following conclusions can be drawn. Firstly, the postmodernism paradigm is an approach to philosophy, art and culture that emerged as a response to the ideas and values of modernism that were dominant in the 19th and early 20th centuries. Postmodernism rejects the idea that there is a single narrative or truth that can explain the world, and instead, emphasizes the diversity, complexity and relative nature of everything. Second, in the context of its view on language, postmodernism offers several perspectives, among which the key ones are openness to the plurality of languages, the destruction of the concept of binaries and oppositions, the importance of meta-narrative, and intertextuality. Postmodernism is present to provide an alternative to new ways of thinking in knowledge, especially by prioritizing the principle of respecting differences in plural particularities, as a counter to the thesis of modernism which believes in the importance of the principle of uniformity and universality.
 
Research Implications: Studying the postmodernist paradigm and its views on language can open insight into the complexity and dynamics of language in various contexts. This influences how we understand the world, interact with others, and organize our knowledge.
 
Originality/Value: The value and originality of the study of postmodernism and language paradigms lies in its ability to raise new questions, provoke critical thinking, and open space for new developments in various disciplines and cultural practices.
The Influence of Discipline, Work Environment, and Organizational Commitment on Employee Performance through Motivation in PT. Bank People Indonesia Tbk Makassar City Region
Authors: Jelly Yunita Lessar , Mus Abdul Rahman , Ramlawati  , Serang Serlin
Published: April 2024

Purpose: The objectives of this research are: (1) to partially analyze the influence of discipline, work environment, and organizational commitment on motivation at PT. Bank Rakyat Indonesia Tbk Makassar City Region. (2) to partially analyze the influence of discipline, work environment, and organizational commitment on employee performance at PT. Bank Rakyat Indonesia Tbk Makassar City Region. (3) to analyze the influence of motivation on employee performance at PT. Bank Rakyat Indonesia Tbk Makassar City Region. (4) to partially analyze the influence of discipline, work environment, and organizational commitment on employee performance through motivation at PT. Bank Rakyat Indonesia Tbk Makassar City Region.   Methods: The sampling method uses proportionate stratified random sampling and purposive sampling. The data collection method uses a questionnaire. The analysis method uses the Structural Equation Model (SEM).   Results and discussion: The research results prove that: (1) Discipline, work environment, and organizational commitment partially have a positive and significant effect on motivation at PT. Bank Rakyat Indonesia Tbk Makassar City Region. (2) Discipline and organizational commitment partially have a positive and significant effect on employee performance at PT. Bank Rakyat Indonesia Tbk Makassar City Region. (3) The work environment has a positive and insignificant effect on employee performance at PT. Bank Rakyat Indonesia Tbk Makassar City Region. (3) Motivation has a positive and significant effect on employee performance at PT. Bank Rakyat Indonesia Tbk Makassar City Region. (4) Discipline and organizational commitment partially have a positive and significant effect on employee performance through motivation at PT. Bank Rakyat Indonesia Tbk Makassar City Region. (5) (4) The work environment has a positive and insignificant effect on employee performance through motivation at PT. Bank Rakyat Indonesia Tbk Makassar City Region.
Impact of Simulation Manikins to Train Pharmacy Students in Nasal, Throat, and Oral Fluid Swab Collection
Authors: Bryant Ginelle , Bottenberg Michelle , Smith Hayden , Challoner MacKenzie , Fisher Tarah
Published: April 2024

Introduction:
A point-of-care testing (POCT) certificate was implemented in a required pharmacy skills-based course. The purpose of this study was to evaluate the impact of manikins on student confidence in performing POCT for infectious diseases.
Innovation:
Manikins were used to train second-year pharmacy students on nasal swabs, throat swabs, and oral fluid swabs. Student skills were assessed on manikins first, then on a peer. Proficiency was defined as a score of 90% or higher. Students completed a pre- and post-training survey regarding their confidence performing swabs. Student confidence was based on Likert style responses (i.e., ‘Strongly Disagree’ [score: 1], to ‘Strongly Agree’ [score: 5]) performing the swabs. Median change in confidence was calculated using quantile regression.   
Findings:
All students (n=63) demonstrated proficiency in performing swabs. Median confidence for nasal, throat, and oral fluid swabs changed by 2.0 (95% CI: 1.5, 2.5), 2.0 (95% CI: 1.5, 2.5), and 2.0 (95%CI: 1.3, 2.7), respectively. The majority of students reported time spent practicing was adequate for the nasal (n=51, 81%), throat (n=51, 81%), and oral fluid swab (n=59, 94%). All participating students reported manikins to be moderately (n=17, 27%) or extremely (n=46, 73%) valuable, and all students rated their overall experience with manikins as positive (n=63, 100%). Student comments revealed manikins helped to visualize anatomy, practice skills without peer discomfort, and minimize risk during the COVID-19 pandemic.  
Conclusion:
This study demonstrated that inclusion of practice on manikins increased student confidence in performing POCT for infectious diseases.  In addition, the majority of students indicated that the use of manikins was valuable to their learning and reported feeling prepared to perform POCT in practice after using the manikins.
“My UC Story”: A Qualitative Descriptive Study Describing the Patient Journey for Ulcerative Colitis
Authors: Jradi Amy , Xai Jane , Seet Tony , Albon Simon
Published: April 2024

Background: Personal perspectives of patients are seldomly reported in the literature, most notably their journey to diagnosis. Literature is heavily focused on the patient journey from a healthcare professional’s point of view during the treatment process. The objective of this study is to conduct a qualitative study on a video sharing site, YouTube, to determine if the patient journey from a subjective perspective is truly linear for those who suffer from ulcerative colitis.

Methods: Phrases searched on YouTube included “ulcerative colitis story” and “ulcerative colitis diagnosis story”. Video monologues chronicling the patient journey before diagnoses were transcribed using the YouTube transcription function to identify patterns amongst users’ experiences. Thematic analysis was used to identify whether certain themes were present in the monologues. Analysis was performed using NVivo 12 QRS International and used line-by-line coding to create an initial codebook that represented the concepts covered in the monologues.

Results: We viewed a total of 48 videos and included 29 videos from 2010 to 2020 for qualitative analysis. Overall, three major themes were identified in the patient journey prior to ulcerative colitis diagnosis:1) initial symptoms 2) initial encounter with the healthcare system 3) gastroenterologist referral.

Conclusions: The literature depicts the patient journey as a linear path. This qualitative study discovers that the reality of the patient journey is in fact non-linear. Pharmacists are the most accessible health care professionals and can help guide patients in prioritizing signs and symptoms to streamline the non-linear path that patients experience.
Changing the World One Story at a Time
Authors: Pruitt Cherri Jacobs
Published: April 2024

What if there is a way to transform society and create a more caring, equitable, and connected world? The Power of Partnership (POP) podcast brings you the people who are working to do just that: people who are helping to build a world that values caring, nature, and shared prosperity. They are applying the Partnership ethos, the ground-breaking alternative to Domination systems that are at the root of our most pressing challenges. In this article, POP podcast producer and host Cherri Jacobs Pruitt provides an overview of how the podcast started and what listeners can expect from each episode.
Analysis of software products and the study of automation of processes in the field of monitoring purchases and goods.
Authors: Perelygin Ivan
Published: April 2024

The subject of this report is a comparative analysis of software products and a study of business processes in the field of optimization of purchases and monitoring of goods. Within the framework of this study, the following tasks were set: the study of existing software solutions for optimizing procurement processes, the analysis of their functionality and effectiveness, as well as the study of business processes of companies in the field of monitoring goods. As a result of this research, an analysis of various software products was carried out, their advantages and disadvantages were identified, as well as current business processes were analyzed and opportunities and potential for optimization were identified. The obtained results and conclusions can be used to develop recommendations for improving procurement processes and monitoring of goods in organizations. In this study, a comparative analysis of software solutions for automating procurement processes is carried out. The research methodology included an analysis of the functionality, effectiveness and cost of the programs, as well as the study of user feedback and industry experts. The results made it possible to identify the main advantages and disadvantages of each software considered. The study of the main characteristics and functionality of procurement management systems represents a significant contribution to the field of information technology and business process management. An analysis of the comparative characteristics of ERM systems, their integration capabilities and compliance with business needs allows us to identify key factors for successful automation of procurement processes. This study not only expands scientific understanding in the field of procurement automation, but also provides practical recommendations for choosing the optimal procurement management system. The conclusions of the work emphasize the importance of customizing the software to the unique needs of the organization in order to achieve optimal efficiency and effectiveness in procurement management. The comparison table of the disadvantages of ERM systems presented in the final part by key parameters allows you to highlight the main advantages and disadvantages of each software product, which is an important step in choosing the most appropriate solution for a particular business. Thus, this study not only contributes to the development of scientific knowledge in the field of procurement management, but also provides valuable practical recommendations for the business community, helping to increase the efficiency and effectiveness of procurement processes in a modern business environment.
PENGARUH RAZIA LAPANGAN TERHADAP KEPATUHAN WAJIB PAJAK KENDARAAN BERMOTOR DALAM MENUNJANG PENCAPAIAN TARGET PADA UPTP SAMSAT WILAYAH GOWA
Authors: Burhan Imron , Sari Den Ka Veronika , Ilham Ilham , Nirmala Sari Sri , Arifin Rukhminih , Nur’Aeni Nur’Aeni
Published: April 2024

Taxpayer compliance are inspections carried out jointly on the highway by members of the police for efficiency and effectiveness in order to avoid repeated inspections and harm the community (Wulandari, M., & Sulistyowatie, S, 2017), by conduction inspections against taxpayers, besides that field raids are carried out in order to narrow the movement of vehicle tax arrears. This study aims to determine the effect of inspection raids on vehicle tax on taxpayer compliance in paying vehicle taxes as a support for achieving targets at UPTP SAMSAT Gowa Region. In this study using quantitative methods. The data used in this study are primary and secondary data with data collection techniques by using a questionnaire. Samples in this study is 183 community populations who were caught by inspection in Gowa Regency. The data analysis technique used simple linear regression analysis using SPSS 20. Result of the study showing that inspection had a significant effect on taxpayer compliance. Taxpayer compliance will continue to increase when enforced inspection regulary.
Efektivitas Beberapa Jenis Pupuk Hayati Terhadap Produksi Kacang Merah Varietas Inerie
Authors: Lewar Yosefina , Hasan Ali , Vertygo Stormy
Published: April 2024

Tujuan penelitian adalah mengkaji jenis pupuk hayati terbaik dalam meningkatkan pertumbuhan dan hasil  kacang merah Varietas Inerie di dataran rendah. Penelitian dilaksanakan pada Juli - November 2022 berlokasi di lahan  milik petani. Penelitian menggunakan Rancangan Acak Kelompok dengan faktor yang diteliti beberapa jenis pupuk hayati, yaitu : H0 : Tanpa Pupuk Hayati, H1 : Liquid Organic Biofertilizer, H2 : Bion-Up, H3 : M-Bio, H4 : Bio-Konversi, H5 : Bio HYT, H6 : Bioboost, dan H7 : Bio CBA Grow. Hasil penelitian menginformasikan bahwa pupuk hayati bioboost lebih efektif  terhadap pertumbuhan dan hasil  tanaman kacang merah Varietas Inerie di dataran rendah, yakni laju asimilasi bersih 0,00559 g/cm2/minggu, total klorofil daun 17,632 mg/g, jumlah polong berisi 13,344 polong, jumlah benih 43,281 butir, dan berat benih 14,713 g.

 

Kata kunci : kacang merah, pupuk hayati, varietas Inerie
Kinerja Rantai Pasok Industri Kopi Bubuk di Kecamatan Kemiling Kota Bandar Lampung
Authors: Riantini Maya , Affandi Muhammad Irfan , Nur’aini Lestari Gita , Kusnandi Savira Adelia
Published: April 2024

Penelitian ini bertujuan untuk menganalisis pola aliran rantai pasok dan kinerja rantai pasok agroindustri kopi bubuk di Kecamatan Kemiling Kota Bandar Lampung. Metode sensus digunakan dalam penelitian ini, dengan mengambil semua agroindustri kopi bubuk di Kecamatan Kemiling Kota Bandar Lampung yang berjumlah lima. Responden pada penelitian ini yaitu pemilik agroindustri, petani kopi, pedagang pengumpul,  pedagang besar, pedagang pengecer, dan konsumen kopi bubuk.  Teknik pengambilan sampel untuk responden rantai pasok menggunakan metode  snowball sampling. Pengumpulan data penelitian dilakukan pada Bulan Januari sampai dengan Februari 2022.  Analisis data yang digunakan yaitu metode deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa secara keseluruhan, aliran produk, aliran uang, dan aliran informasi yang terjadi pada rantai pasok sudah berjalan dengan baik. Beberapa indikator kinerja rantai pasok petani  berada di bawah nilai  parity, sedangkan kinerja rantai pasok pedagang pengumpul dan agroindustri seluruhnya berada pada kriteria superior dan advantage.
Characteristics of Redestilled Dried Banana Leaves Liquid Smoke
Authors: Suroso Erdi , Pratondo Utomo Tanto , Al Rasyid Harun , Fauzi Aqshal
Published: April 2024

Banana leaves belong to the waste products of the banana plant and are a potential source of liquid smoke due to their abundance, containing 10.85% cellulose, 19.95% hemicellulose and 18.21% lignin. Liquid smoke has many uses, including as an antibacterial agent and food preservative. The purpose of this study was to identify the characteristics of the liquid smoke from redistilled dried banana leaves. The process of making liquid smoke by pyrolysis, precipitation, distillation, and adsorption with activated zeolites. Liquid smoke is then physically observed for color and flavor, tested for compound content using GC-MS tests, and analyzed descriptively. The results showed that the liquid smoke from redistilled dried banana leaves had a mild taste and pale yellow color. was found to contain 13.09% area, carbonyls in 1.42% area, and no HPA compounds..
Effect of Preoperative Oral Carbohydrate Loading on Perioperative Hemodynamic in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Study
Authors: Kausar Sana , Mohammad Hashim , Patel Nupur B. , Shamim Rafat , Priya Vansh
Published: April 2024

Background:

Conventional preoperative fasting is associated with intravascular volume contraction, increased stress, hyperglycaemia in the perioperative period. Recently, the concept of preoperative carbohydrate loading is introduced. This study was conducted to reveal the relation between use of carbohydrate-rich fluid and perioperative hemodynamic, perfusion index, and glucose control of the patients, who were undergoing elective laparoscopic cholecystectomy under general anesthesia.

Methods:

This study is a double-blinded prospective randomized control study. The patients, who met the inclusion criteria were randomly divided into 2 groups of 43 each with the help of computer-generated randomization method. Patients who received preoperative carbohydrate loading and patients who follow conventional preoperative fasting for surgery were labelled as Group E and Group S respectively. Incidence of hypotension was the primary outcome; variation in blood pressure, heart rate, perfusion index, and blood glucose level were the secondary outcomes.

Results:

Intraoperative hypotensive episodes were significantly lower in the carbohydrate loading group in comparison to the conventional fasting group, p=0.023. The systolic, diastolic blood pressure and perfusion index were significantly lower in the conventional fasting group. Also, the heart rate was significantly higher in the conventional fasting group. Numeric rating scale, the score for pain taken at 1 hour postoperatively was significantly lower in the carbohydrate loading group. Blood glucose level postoperatively after 24 hours was significantly more in the conventional fasting group.

Conclusion:

The carbohydrate loading group has better hemodynamic stability and optimal intravascular volume after induction and intraoperatively. Also, the carbohydrate loading group had better glycaemic control and better pain relief postoperatively.
Analysis of genetic diversity of banana cultivars using RAPD and ISSR markers
Authors: Duhan J.S. , Choudhary D. , Poonia A.K. , Sadh P.K. , Kajla S.
Published: April 2024

In the present study, the genetic diversity of 23 banana genotypes was analyzed using 40 decamer RAPD primers and thirty-six ISSR primers. A total of 438 amplicons were generated by RAPD primers of 100 to 1500 bp size and 472 amplicons were generated using ISSR markers with 150 to 1500 bp size. The polymorphism ratio was reported as 94.98% for RAPD primers and 98.50% for ISSR primers. The marker system data was combined for cluster analysis and a dendrogram was generated in which two different clusters of banana genotypes were separated. Based on cluster data analysis, the similarity coefficient reported between different banana genotypes was 0.61 to 0.88 for RAPD markers and 0.117 to 0.683 for ISSR markers. In contrast, the combined data analysis resulted in a similarity coefficient of 0.61 to 0.87. This analysis will provide the relationship between the existing germplasm of bananas and the genetic variability in the existing germplasm that can be used to improve the present banana cultivar by providing options for the breeders to develop new varieties.
Review Focusing on Molecular Mechanisms of Induction of Apoptosis in Different Cancers by a Flavone: Luteolin
Authors: Murti Yogesh , Singhal Manas , Agrawal Krishn Kumar
Published: April 2024

Luteolin (3’,4’,5,7-tetrahydroxyflavone), an emerging anticancer flavone, has been reported to have other activities like antioxidant, antidiabetic, antimicrobial, anti-inflammatory, neuroprotective, cardioprotective and anti-allergic activities. In recent times, more attention has been paid to search the mechanism of apoptogenic effects of luteolin. Reports about the anticancer mechanism of luteolin published in Google Scholar, Scopus, Web of Science and PubMed are summarized in this study. Luteolin has shown potential against different cancers like breast, gastric, lung, hepatocellular, prostate etc. Mechanism of apoptosis in breast cancer cells is reported as inhibition of epidermal growth factor receptor-mediated pathway in MDA-MB 231 ER negative breast cancer cells by luteolin. Induction of apoptosis was linked with the inactivation of the critical kinases ERK and AKT in addition to P70S6K and mTOR in prostate cancer cells. Our literature survey shows that luteolin is a lead compound for anticancer chemotherapy. Further molecular mechanisms of induction of apoptosis should be explored in respect to luteolin in different cancer treatments.
A global view of T cell metabolism in Systemic Lupus Erythematosus
Authors: Goetz Andrew , Cagmat Joy , Brusko Maigan , Brusko Todd , Rushin Anna , Meritt Matthew , Garrett Timothy , Morel Laurence , Dixit Purushottam
Published: April 2024

Impaired metabolism is recognized as an important contributor to pathogenicity of T cells in Systemic Lupus Erythematosus (SLE). Over the last two decades, we have acquired significant knowledge about the signaling and transcriptomic programs related to metabolic rewiring in healthy and SLE T cells. However, our understanding of metabolic network activity derives largely from studying metabolic pathways in isolation. Here, we argue that enzymatic activities are necessarily coupled through mass and energy balance constraints with in-built network-wide dependencies and compensation mechanisms. Therefore, metabolic rewiring of T cells in SLE must be understood in the context of the entire network, including changes in metabolic demands such as shifts in biomass composition and cytokine secretion rates as well as changes in uptake/excretion rates of multiple nutrients and waste products. As a way forward, we suggest cell physiology experiments and integration of orthogonal metabolic measurements through computational modeling towards a comprehensive understanding of T cell metabolism in lupus.
“Naked Nickel”-Catalyzed Amination of Heteroaryl Bromides
Authors: Saeb Rakan , Boulenger Bryan , Cornella Josep
Published: April 2024

In this article we report that the air-stable “naked nickel” [Ni(4-tBustb)3] is a competent catalyst in thermal C–N bond formation between (hetero)aryl bromides and N-based nucleophiles. The catalytic system is characterized by a “naked nickel” complex and Zn, the absence of external light sources, photocatalysts, exogeneous ligands, as well as electrical setups. By applying this method, various heteroaryls bearing Lewis-basic heteroatoms can be accommodated and directly aminated with a set of primary and secondary amines.
Acetylation of Rec8 cohesin complexes regulates reductional chromosome segregation in meiosis
Authors: Li Ziqiang , Liu Yu , Jones Andrew W , Watanabe Yoshinori
Published: April 2024

For establishing sister chromatid cohesion and proper chromosome segregation in mitosis in fission yeast, the acetyltransferase Eso1 plays a key role. Eso1 acetylates cohesin complexes, at two conserved lysine residues K105 and K106 of the cohesin subunit Psm3. Although Eso1 also contributes to reductional chromosome segregation in meiosis, the underlying molecular mechanisms have remained elusive. Here, we purified meiosis-specific Rec8 cohesin complexes localized at centromeres and identified a new acetylation at Psm3-K1013, which largely depends on the meiotic kinetochore factor meikin (Moa1). Our molecular genetic analyses indicate that Psm3-K1013 acetylation cooperates with canonical acetylation at Psm3-K105 and K106, and plays a crucial role in establishing reductional chromosome segregation in meiosis.
Trends in tracheal, bronchial and lung cancer attributed to smoking in South America: Global Burden of Disease analysis 1990-2019
Authors: Salerno Pedro Rafael Vieira de Oliveira , Palma Dallan Luis Augusto , Rodrigues Pereira Gabriel Tensol , Pego Fernandes Paulo Manuel , Mingarini Terra Ricardo , Rajagopalan Sanjay , Al-Kindi Sadeer G , Oliveira Salerno Juliana Vieira de
Published: April 2024

Objective.

To investigate the burden of tracheal, bronchus, and lung (TBL) cancer due to tobacco exposure in the last 30 years in 12 South American countries.

Methods.

We used the Global Burden of Disease (GBD) 2019 exposure-response function to analyze the total tobacco, smoking, and secondhand smoke exposure-related TBL cancer deaths and disability-adjusted life years (DALYs), for 12 South American countries, between 1990 and 2019. Metrics were described as absolute numbers or rates per 100 000 individuals. The relative change in burden was assessed by comparing the 1990-1994 to 2015-2019 periods.

Results.

In 2019, the all-ages number of TBL cancer deaths and DALYs associated with tobacco exposure in South America was 29 348 and 658 204 in males and 14 106 and 318 277 in females, respectively. Age-adjusted death and DALYs rates for the region in 2019 were 182.8 and 4035 in males and 50.8 and 1162 in females, respectively. In males, 10/12 countries observed relative declines in TBL death rates attributed to tobacco exposure while only 4 countries reduced their mortality in females.

Conclusion.

While significant efforts on tobacco control are under place in South America, substantial burden of TBL cancer persists in the region with significant sex-specific disparities. Increased country-specific primary data on TBL cancer and tobacco exposure is needed to optimize healthcare strategies and improve comprehension of regional trends.
Herbaceous plants as heavy metals accumulators in conditions of ash and slag dumps
Authors: Семак У. Й. , Миленька M. M.
Published: April 2024

Storage of ash and slag waste causes a number of environmental problems, including the transformation of natural geochemical cycles and the change of the natural radioactive background due to the increased concentration of heavy metals and radioactive isotopes in coal combustion products. Plants can provide an effective approach for the analysis and monitoring of heavy metals contamination. Additionally, vegetation plays a significant role in the restoration and remediation of heavy metal-contaminated soils. The application of plants in phytoremediation is a green and sustainable solution for decontaminating polluted sites. Moreover, the key role in the restoration of contaminated sites belongs to native species. Within the presented research, the abilities of native dominant species to accumulate and tolerate heavy metals in conditions of ash and slag dumps were investigated on a limited number of samples. Primary analysis of the bioaccumulation of heavy metals through the bioaccumulation coefficient showed that zinc has the highest accumulation capacity in the studied species. The ability to bioaccumulate the analyzed heavy metals decreases in the following order: Zn > Fe > Cu > Mn > Cd > Ni > Pb. Indexing the biogeochemical activity of the tested species showed higher levels of biochemical activity for Anthemis arvensis L. than for Achillea millefolium L., however, these data need to be confirmed by statistical analysis. Determination of the translocation index of elements reflected the high mobility of zinc and cadmium with a high rate of transferring to above-ground biomass, but the potential for accumulation requires scaling up the experiment with the involvement of a larger number of samples and performing statistical data processing. Due to their ability to accumulate heavy metals in roots, plant species could be used for phytostabilization. Establishing methods of biomonitoring and the development of green reclamation technologies with native species application need further research with both selected species and other local species. The presented research showed primary results of bioindication and references for phytoremediation of heavy metal contamination of the ash and slag dumps, which is relevant for other similar environmental conditions.
How Do Indonesian Student-Teachers Experience Wellbeing during Research Supervision? A Qualitative Interview Study
Authors: Nimasari Elok Putri , Setiawan Slamet , Munir Ahmad
Published: April 2024

Research supervision is a collaborative and interactive process that plays a significant role in shaping the successful outcome of a student's learning in higher education. Crucial, but often neglected, we believe that the role of students’ wellbeing during dialogic and sociocultural interaction such as communication styles and expectations during thesis supervision raises issues concerning best practice in students' success. This qualitative interview study investigated thirteen student-teachers’ wellbeing at one private and one public English school in an additional language university context. Drawing on Seligman's positive psychology and Longo’s wellbeing thematic coding analysis, we reported how professional dialogue from dialogic and sociocultural perspectives in the supervisory interaction shape student-teachers’ five wellbeing dimensions: positive emotion, positive relationship, engagement, meaning and accomplishment. Micro elements of wellbeing were identified and analysed inductively. The findings illuminated how institutional and environmental cultures intricately shape students' wellbeing, highlighting that wellbeing is not only constructed through supervisory advice but also dynamically challenged and nurtured through ongoing dialogic interactions among students. The policy and practical implications arising from this research were discussed.
The Mediate Effect Of Sharia Compliance on The Performance of Islamic Banking in Indonesia
Authors: Usdeldi Usdeldi , Nasir M. Ridlwan , Ahsan Muhamad
Published: April 2024

This study aimed to prove whether Sharia Compliance (SC) mediates the influence of Good Corporate Governance (GCG), Sharia Supervisory Board (SSB), and Corporate Social Responsibility (CSR) on financial performance and maqashid sharia performance in Islamic Commercial Banks (ICBs) in Indonesia. A regression analytical method was employed based on Structural Equation Modeling with panel data in the annual report published by ICBs in Indonesia for the period 2014-2019. The results proved that SC mediated GCG and CSR on maqashid sharia performance positively while negatively mediated them on financial performance. At the same time, it did not mediate SSB on both financial performance and maqashid sharia performance. Based on these findings, policymakers should launch regulations on the disclosure of the dimensions GCG, SSB, CSR, and SC in the annual reports of ICBs. In practical implementation, ICBs should improve GCG, CSR, and SC as the performance of Islamic banking-supporting dimensions, and, evaluate SSB as the non-supporting one
The Role of Financial Literacy, Access of Finance, Financial Risk Attitude on Financial Performance. Study on SMEs Jogjakarta
Authors: Kristanto HC R. Heru -
Published: April 2024

Micro, small and medium enterprises (SMEs) contribute significantly to economic development. Financial literacy, access to finance, and attitudes toward financial risk play a key role in improving the performance of SME participants. The primary aim of this study is to examine the impact of financial literacy on access to finance, attitudes to financial risk, and financial performance. The impact of financial literacy on home improvement financial performance examines the mediators of access to finance and attitudes to financial risk. Statistical analysis model used mediated regression. The research sample is the Actors' SMEs in Yogyakarta. The sampling technique was purposive sampling. Respondents were SMEs as many as 276 entrepreneurs. The mediation regression analysis tool uses PLS. The results of the research show: 1) Financial literacy has a positive effect on financial performance. 2) Financial literacy has a positive impact on access to finance. 3) Access to finance mediates the impact of financial literacy on financial performance. 4) Financial literacy has a positive impact on attitudes toward financial risk. 5) Attitudes to financial risk mediate the impact of financial literacy on financial performance. Survey results recommend the importance of improving financial literacy, easy access to finance, and attitudes toward financial risks. You need the ability to analyze small business risks to improve your company's financial performance and sustainability. Providing financial education to entrepreneurs requires the will of state agencies, the entrepreneurs themselves, and educational institutions.
Could Size Moderate Managerial Ownership, Institutional Ownership, and Audit Quality of Tax Avoidance Occurs in Southeast Asia’s Banking?
Authors: Melyaningrum Dinda Rahmatur , Supriyati Supriyati - , Murdiawati Dewi - , Prananjaya Kadek Pranetha
Published: April 2024

This study aims to determine the effect of managerial ownership, institutional ownership, and audit quality on tax avoidance and to determine the role of firm size as a moderator in strengthening or weakening the influence of the three independent variables on tax avoidance. The population used in this study is the financial statements and annual reports of banking companies in Southeast Asia which are available on the stock exchange sites of each country and the official websites of related companies in the 2015-2019 period. The sampling technique is used a purposive sampling method with the final result of as many as 144 units of analysis. Analysis of the data used is Multiple Linear Regression Analysis to determine the independent influence variables on dependence and Moderation Regression Analysis to determine the role of moderating variables. The result shows that managerial ownership and audit quality do not affect tax avoidance, while institutional ownership can negatively affect tax avoidance. Moderation analysis shows that firm size can affect independent institutional ownership variables and audit quality on tax avoidance. However, managerial ownership does not affect tax avoidance.
EXPLORING THE BENEFITS OF CROSS-IMPLEMENTING CYBERSECURITY STANDARDS TO COMBAT RANSOMWARE CYBER CRIMES
Authors: Dudykevych Valeriy , Harasymchuk Oleh , Partyka Andrii , Sovyn Yaroslav , Nyemkova Elena
Published: April 2024

This article is devoted to research and analysis of recent cyberattacks on critical infrastructure of Ukraine using ransomware. In the article, the authors emphasize the growing importance of cyber security in today's digital environment due to the increase in the number of cybercrimes, in particular, attacks using ransomware. As a result, it is important to apply cybersecurity standards to effectively combat these threats. The article emphasizes the importance of implementing comprehensive measures that cover technical, organizational, and legal aspects to combat ransomware cybercrimes. The article also provides the main methods and tools for successfully countering ransomware, both for ordinary users and representatives of businesses and critical infrastructure facilities. Also, this paper offers an exploration of the benefits of cross-implementation of cybersecurity standards in the context of combating ransomware attacks and cybercrimes. The authors consider the methods and approaches to cyber security auditing, determine the advantages of the method of cross-implementation of standards, and offer recommendations for its effective use to ensure the security of information systems. This approach contributes to the creation of a comprehensive defense system that reduces the probability of success of attacks using ransomware and provides greater resilience of the organization to incidents and cybercrimes. The results of the study can be useful for organizations seeking to improve their cyber security and protect themselves from ransomware attacks and cybercrimes.
Local Epistemic Consciousness as A Basis for Attaching Responsibility for Marine Conservation in the Indonesian Coastal Region
Authors: Putra Andri Azis , Chamidah Nurul , Rosyidi Moch. Imron , Suwarno Panji
Published: April 2024

The sea is the primary resource that needs to be maintained by all people based on its benefits. However, marine conservation efforts are only carried out by individuals related to them, especially local coastal communities. This condition implies that conservation efforts are never carried out optimally due to a lack of consciousness. This research aims to utilize the structure of epistemic consciousness as a means to convey social responsibility for protecting the marine environment. This research will employ a philosophical hermeneutics approach involving epistemology, ethics, human philosophy, and psychotherapy. The results of this research demonstrate that epistemic consciousness in an individual can enhance their abilities and understanding in adapting their knowledge framework to environmental conservation efforts. This consciousness is also capable of guiding an individual's responsibility in processing information and making decisions in specific contexts, especially in the local sense. Instilling a sense of responsibility can be achieved through the use of taglines and the symbolization of religious beliefs and traditional customs.
GAS SUPPLY EFFICIENCY BASED ON DIGITAL TRANSFORMATION
Authors: Romanova T. , Beloglazova T.
Published: April 2024

Abstract. The relevance of the research is based to the need for effective implementation of digital technologies in the field of gas supply. The study of energy supply from natural gas was carried out in accordance with the functional patterns of technological processes and gas consumption factors in conjunction with the directions of digital transformation.

Subject: The main aim of the research to define and propose criteria for digital transformation, based on features of the gas supply industry for the gradual progressive development of the regional economy.

Materials and methods: The functional relationship with gas supply was determined based on the analysis and generalization of the main directions and criteria for the digital transformation. The method of comparing the results of digital transformation with a technological approach and with a relative assessment of investments was used.

Results: Groups of indicators that are technologically interconnected in gas supply are presented as criteria for digital transformation. An additional function to expand the boundaries of evaluating the economic efficiency of digital technologies is to provide a mechanism for creating added value in Russia. The increasing capitalization through investments in digital technologies is not a factor in increasing efficiency without a reasonable practical effect.

Conclusions: The implementation of digital transformation should not lead to an excessive increase in tariffs for gas supply to Russian regions, since energy supply is a necessary condition for the development of the economy.
Changing Pesantren Program through Turats Police Innovation: Building the Comprehensive and Quality Students
Authors: Habibi Riki , Wahyuni Anisa , Saepurrohman Aep , Zaqiah Qiqi Yuliati , Supiana Supiana
Published: April 2024

This article aims to describe research on Islamic Boarding School Curriculum Transformation Through Turats Pole Innovation: Building a Holistic and Qualified Generation of Santri. The transformation of the pesantren curriculum through the Turats Pole innovation is an approach to building a holistic and quality generation of students. The traditional pesantren curriculum has played an important role in maintaining and developing religious and cultural values in society. Turats Pole is a concept that combines traditional and contemporary approaches in Islamic boarding school education. This study uses a qualitative method with a descriptive approach. Data collection techniques used are observation, interviews, and documentation studies. Based on the research results, this transformation aims to integrate religious values and modern science so that students not only become religious experts but also have a good understanding of science and technology. It is hoped that the transformation of the pesantren curriculum through the Turats Pole innovation will produce a generation of students who are not only spiritually and morally strong but also have knowledge and skills that are relevant to the demands of the times. Thus, pesantren can play an active role in the development of society and the nation as a whole.
Development of Environmentally Inspected Boarding School Curriculum at Integrated Salafi Boarding School
Authors: Irawan Nandang , Handritin Cici , Susilawati Eli , Zaqiah Qiqi Yuliati , Supiana Supiana
Published: April 2024

This article aims to describe research on Darussyifa Al-Fithroh YASPIDA Sukabumi Integrated Salafi Islamic Boarding School, an Islamic educational institution that is committed to developing an environmentally sound Islamic boarding school curriculum. This curriculum aims to provide students with an understanding of the importance of protecting and preserving the environment in the context of Islamic religious teachings. The development of an environmentally friendly pesantren curriculum at Darussyifa Al-Fithroh YASPIDA Sukabumi Integrated Salafi Islamic Boarding School was carried out through several stages. First, identify the needs and potential of the environment around the pesantren. This is done by conducting environmental studies which include analysis of natural conditions, natural resources, and existing environmental problems. After identifying environmental needs and potential, the next step is to formulate learning objectives that are oriented toward developing students' awareness and responsibility for the environment. The objectives of this lesson include understanding the importance of preserving nature, using natural resources wisely, and efforts to reduce negative impacts on the environment.
Pengaruh Net Profit Margin, Return On Equity, Return On Asset, dan Current Ratio terhadap Harga Saham Pada Perusahaan Manufaktur Sektor Industri Barang dan Konsumsi Yang Listing di Bursa Efek Indonesia Pada Tahun 2018 - 2021
Authors: Rusmana Haris , Yuliani Rahma
Published: April 2024

This research was conducted to prove and analyze (1) the effect of Net Profit Margin on stock prices, (2) The effect of Return On Equity on Stock Prices (3) the effect of Return On Assets on stock prices (4) and the effect of Current Ratio on stock prices. The population in this study are manufacturing companies in the goods and consumption sector which are listed on the Indonesia Stock Exchange from 2018-2021, totaling 111 companies. The sample in this study consisted of 25 companies. The type of data in this study is secondary data obtained by collecting document/copy archival data through the Indonesian Stock Exchange website. This type of research is quantitative research. The analysis technique used in this study was multiple regression analysis using the IBM SPSS Statistics application version 25. The results of this study indicate that the Net Profit Margin, Return On Equity, Return On Assets, Current Ratio has no significant effect on stock prices. The coefficient of determination is 0.127, which means 12.7%, which means that the stock price is affected by 12.7% by Net Profit Margin, Return On Equity, Return On Assets, Current Ratio, while the rest is explained by other variables. This shows that there are variables outside the research that can affect stock prices.