bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Evaluation of Rabies Virus Meningoencephalomyelitis in a Dog
Authors: Barnes Heidi L. , Chrisman Cheryl L. , Farina Lisa , Detrisac Carol J.
Published: September 2014

A 6-month-old, female, mixed-breed dog presented for acute, progressive, flaccid paraplegia and bilateral pelvic-limb hyperesthesia. A lymphocytic pleocytosis with 366 mg/dL protein was found on cerebral spinal fluid (CSF) evaluation. Electromyography (EMG) demonstrated positive sharp waves and fibrillations in the left pelvic limb; the M wave of the left sciatic nerve was not obtainable by nerve stimulation. Seizures and dementia began during recovery from anesthesia. Six days after onset of paralysis, the dog was euthanized. Direct fluorescent antibody testing of the brain was positive for raccoon rabies virus. This case demonstrates clinical evaluation, CSF analysis, and EMG in an animal with rabies meningoencephalomyelitis.
Serosurvey of AntiBabesia Antibodies in Stray Dogs and American Pit Bull Terriers and American Staffordshire Terriers From North Carolina
Authors: Birkenheuer Adam J. , Levy Michael G. , Stebbins Martha , Poore Matthew , Breitschwerdt Edward
Published: September 2014

Stray dogs (n=359) and kennel dogs (n=149) from North Carolina were tested for evidence of antiBabesia antibodies. AntiBabesia antibodies were detected in 21/359 and 22/149 of the stray and kennel dogs, respectively. A total of 57 dogs from both groups were tested for babesiasis by light microscopy and polymerase chain reaction (PCR). Babesia deoxyribonucleic acid (DNA) was detected in 3/28 of the stray dogs and 14/29 of the kennel dogs. When Babesia DNA was detected by PCR, the species-specific PCR results differed from the Babesia species antibody titer results in 6/17 of the PCR-positive dogs. There was no association between antiBabesia antibodies and the presence of ticks. There are currently Babesia gibsoni epizootics affecting American pit bull terrier kennels.
Clindamycin in the Treatment of Babesia gibsoni Infections in Dogs
Authors: Wulansari Retno , Wijaya Agus , Ano Hitoshi , Horii Yoichiro , Nasu Tetsuo , Yamane Shin-ichi , Makimura Susumu
Published: September 2014

This report examines the effectiveness of clindamycin for the treatment of babesiosis in dogs (n=10) experimentally infected with Babesia gibsoni (B. gibsoni). Clindamycin (25 mg/kg body weight, per os, q 12 hours for 14 days) gradually reduced parasitemia levels and induced morphological changes that indicated degeneration of parasites (e.g., segmentation; size reduction; localization in the cell limbic and/or torn state of the nucleus; and swelling, decrease, or disappearance of the cytoplasm) in the majority of dogs. Clindamycin treatment reduced the clinical symptoms characteristic of Babesia infection, including anemia, anorexia, and listlessness. Clindamycin might be useful as a medicine for treatment of B. gibsoni infection.
The Relationship of Resting S-T Segment Depression to the Severity of Subvalvular Aortic Stenosis and the Presence of Ventricular Premature Complexes in the Dog
Authors: Davainis Grace M. , Meurs Kathryn M. , Wright Nicola A.
Published: September 2014

Electrocardiograms (ECG) from 35 dogs with subvalvular aortic stenosis (SAS) with a left ventricular outflow tract pressure gradient (PG) of ≥50 mm Hg were retrospectively evaluated for S-T segment depression (STD, ≥0.2 mV in lead II). Pressure gradient, age, heart rate (HR), and number of ventricular premature complexes (VPCs) on a 24-hour ambulatory ECG for dogs with STD were not significantly different from those for dogs without STD. The S-T segment deviation did not correlate significantly with PG, age, HR, or VPCs. The significance of STD in the dog with SAS remains uncertain. Long-term prospective studies are needed to fully understand this observation.
Influence of Antiarrhythmia Therapy on Survival Times of 19 Clinically Healthy Doberman Pinschers With Dilated Cardiomyopathy That Experienced Syncope, Ventricular Tachycardia, and Sudden Death (1985–1998)
Authors: Calvert Clay A. , Brown John
Published: September 2014

Overtly healthy Doberman pinschers, having moderate to severe myocardial failure secondary to dilated cardiomyopathy, which experienced ventricular tachycardia, syncope or collapse, and sudden death were studied to determine the effect of antiarrhythmic medication on their clinical outcome. Antiarrhythmia drug therapy may have retarded sudden death in 13 treated dogs compared to the six dogs not administered antiarrhythmia drugs.
Chronic Diaphragmatic Hernia in 34 Dogs and 16 Cats
Authors: Minihan Anne C. , Berg John , Evans Krista L.
Published: September 2014

Medical records of 34 dogs and 16 cats undergoing surgical repair of diaphragmatic hernia of >2 weeks’ duration were reviewed, and long-term follow-up information was obtained. The most common clinical signs were dyspnea and vomiting; however, many of the animals were presented for nonspecific signs such as anorexia, lethargy, and weight loss. Thoracic radiographs revealed evidence of diaphragmatic hernia in only 66% of the animals, and additional imaging tests were often needed to confirm the diagnosis. Thirty-six hernias were repaired through a midline laparotomy; 14 required a median sternotomy combined with a laparotomy. In 14 animals, division of mature adhesions of the lungs or diaphragm to the herniated organs was necessary to permit reduction of the hernia. Fourteen animals required resection of portions of the lungs, liver, or intestine. All hernias were sutured primarily without the use of tissue flaps or mesh implants. Twenty-one of the animals developed transient complications in the postoperative period; the most common of these was pneumothorax. The mortality rate was 14%. Thirty-four (79%) of the animals that were discharged from the hospital had complete resolution of clinical signs, and none developed evidence of recurrent diaphragmatic hernia during the follow-up period. Nine were lost to follow-up.
Intravesical Instillation of Dilute Formalin for the Treatment of Severe Hemorrhagic Emphysematous Cystitis in a Diabetic Dog
Authors: Henrikson Todd D. , Moore Lisa , Biller David S. , Schermerhorn Thomas
Published: September 2014

Intravesical formalin is a known treatment for control of hemorrhagic cystitis caused by multiple etiologies in humans and dogs. This case report documents the successful use of intravesical formalin for the treatment of severe hemorrhagic cystitis that occurred secondary to emphysematous cystitis in a diabetic dog. In addition, a review of emphysematous cystitis and the use of intravesical formalin in human and veterinary medicine is discussed. Formalin instillation into the urinary bladder is an option for life-threatening, refractory cases of hemorrhagic cystitis; but clinicians must be familiar with the proper technique and be aware of potential complications prior to its use.
Pancreatolithiasis and Pancreatic Pseudobladder Associated With Pancreatitis in a Cat
Authors: Bailiff Nathan L. , Norris Carol R. , Seguin Bernard , Griffey Stephen M. , Ling Gerald V.
Published: September 2014

Pancreatolithiasis has been documented to occur naturally in humans and cattle. It has been associated with chronic pancreatitis in humans, and, when found, it may signify the presence of chronic pancreatic disease. This is the first report of a case involving a cat that had both an apparent obstruction with pancreatolithiasis as well as concurrent evidence of chronic pancreatic changes on histopathological evaluation. Additionally, this case documents the presence of a suspected congenital abnormality of a feline exocrine pancreas.
Ureteral Mast Cell Tumor in a Dog
Authors: Steffey Michele , Rassnick Kenneth M. , Porter Brian , Njaa Bradley L.
Published: September 2014

A 6-year-old, castrated male, mixed-breed dog was diagnosed with partial unilateral ureteral obstruction secondary to a ureteral mass. The ureteral mass was surgically resected, and an ureteroneocystostomy was performed. Histopathology of the ureteral mass was consistent with a poorly differentiated mast cell tumor (MCT). The patient recovered well but was euthanized 5 months postoperatively for central nervous system signs. A choroid plexus tumor was diagnosed during necropsy examination. There was no evidence of recurrence or dissemination of the ureteral MCT. Extracutaneous MCTs are rare in dogs, and primary MCT associated with the urinary tract has not previously been reported in the veterinary literature.
Normal and Abnormal Ultrasonographic Findings That Mimic Small Intestinal Intussusception in the Dog
Authors: Patsikas Michail N. , Papazoglou Lysimachos G. , Papaioannou Nickolaos G. , Dessiris Aggelos K.
Published: September 2014

On ultrasonographic examination of the abdomen, the appearance of healthy intestine, enteritis secondary to an intestinal foreign body, and postpartum involution of the uterus may be visualized in some imaging planes as a target-like structure that is subsequently misinterpreted as intestinal intussusception. To avoid misdiagnosis, the ultrasonographer should ensure multi-plane scanning of the lesion, paying particular attention to the completeness of the lesion’s peripheral ring structure and the overall width of the concentric rings of the target-like lesion. The presence of a semilunar or G-shaped hyperechoic center and the visualization of the inner intussusceptum (extending into the intussusception lumen) can be useful ultrasonographic findings that distinguish an intussusception from other lesions or from healthy tissues. These principles are illustrated through the following case presentations.
Outcomes and Complications Associated With Ventral Screws, Pins, and Polymethyl Methacrylate for Atlantoaxial Instability in 12 Dogs
Authors: Sanders Sean G. , Bagley Rodney S. , Silver Gena M. , Moore Michael , Tucker Russell L.
Published: September 2014

Clinical outcomes and complications of a technique used for atlantoaxial stabilization were evaluated in a group of 12 dogs. At surgery, the atlantoaxial joint was realigned and rigidly fixated using cortical bone screws, K-wire, and polymethyl methacrylate. Results in nine dogs were graded as excellent. Results in two dogs were judged as good. One dog was euthanized 17 months after surgery for recurrent cervical pain. Eight dogs had no postoperative complications. The surgical technique described provided an adaptable method for the correction of atlantoaxial instability.
Transnasal Laryngoscopy for the Diagnosis of Laryngeal Paralysis in Dogs
Authors: Radlinsky MaryAnn G. , Mason Diane E. , Hodgson David
Published: September 2014

Four dogs with clinical signs of laryngeal paralysis and three normal dogs were evaluated with transnasal laryngoscopy. Six of these dogs subsequently underwent standard laryngoscopy. For transnasal laryngoscopy, a video endoscope was passed through the left nasal passage after intramuscular sedation and topical anesthesia. The laryngeal opening was observed during spontaneous ventilation. Laryngeal paralysis was diagnosed in four dogs and was confirmed with traditional laryngoscopy in three dogs. Normal motion of the arytenoid cartilages was present in the other three dogs; however, two required mechanical stimulation of the laryngeal mucosa for full evaluation. Transnasal laryngoscopy provided a means for diagnosing laryngeal paralysis in dogs without general anesthesia.
Bone Marrow Hypoplasia Associated With Fenbendazole Administration in a Dog
Authors: Gary Anthony T. , Kerl Marie E. , Wiedmeyer Charles E. , Turnquist Susan E. , Cohn Leah A.
Published: September 2014

A 1.5-year-old Doberman pinscher was presented with sudden-onset of fever and malaise. Twelve days prior to presentation, fenbendazole therapy was initiated for a suspected lungworm infection. Results of a complete blood count on presentation showed pancytopenia, while histopathological evaluation of a bone marrow core sample revealed bone marrow hypoplasia of undetermined etiology. Bactericidal antibiotics and fluid therapy, as well as discontinuation of fenbendazole administration, led to a complete resolution of clinical and hematological abnormalities within 15 days. An idiosyncratic reaction to fenbendazole was suspected based on the absence of infectious, neoplastic, autoimmune, and toxic etiologies, as well as resolution of clinical signs and pancytopenia upon drug withdrawal.
Osteosarcoma of the Humeral Head Associated With Osteochondritis Dissecans in a Dog
Authors: Holmberg Bradford J. , Farese James P. , Taylor David , Uhl Elizabeth W.
Published: September 2014

A 6-year-old, male Labrador retriever was presented for lameness of the right forelimb. The lameness occurred 5 years after the dog was surgically treated for osteochondritis dissecans (OCD) of the caudal right humeral head. Radiographs revealed an expansile, osteolytic lesion occupying the entire caudal half of the right humeral head, and biopsy confirmed the diagnosis of osteosarcoma. Forelimb amputation was performed. Histopathology of the lesion and associated articular cartilage revealed neoplastic osteoblasts extensively infiltrating the marrow space adjacent to scar tissue associated with the previous OCD lesion. This is the first report of an epiphyseal osteosarcoma in the area of a previous OCD lesion in a dog.
A Retrospective Comparison of Cervical Intervertebral Disk Disease in Nonchondrodystrophic Large Dogs Versus Small Dogs
Authors: Cherrone Karen L. , Dewey Curtis W. , Coates Joan R. , Bergman Robert L.
Published: September 2014

Medical records of 144 small-breed dogs (≤15 kg) and 46 medium- to large-breed dogs (>15 kg) with surgically confirmed, Hansen type I, cervical intervertebral disk extrusions were reviewed. The most common clinical presentation was cervical hyperesthesia. The most common sites affected were the second (C2) to third (C3) cervical intervertebral disk space in small-breed dogs and the sixth (C6) to seventh (C7) cervical intervertebral disk space in the larger dogs. Following surgery, 99% of the dogs had resolution of cervical hyperesthesia and were able to ambulate unassisted. Seven (4%) dogs required a second surgery; four of these were large-breed dogs.
Asymmetrical, Transitional, Lumbosacral Vertebral Segments in Six Dogs: A Characteristic Spinal Syndrome
Authors: Steffen Frank , Berger Markus , Morgan Joe P.
Published: September 2014

Clinical findings in six dogs with asymmetrical, transitional, lumbosacral vertebral segments are reported. All dogs exhibited low back pain and varying degrees of asymmetrical cauda equina dysfunction. Results of myelography, epidurography, and magnetic resonance imaging (MRI) indicated a unilateral disk protrusion in all dogs. In the dogs with MRIs, focal degenerative alterations in the vertebral end plates and adjacent body of the vertebra were detected. All dogs were treated with a dorsal laminectomy or hemilaminectomy. Results following surgery were good or excellent in all six dogs.
Spectrum of M-Mode Echocardiographic Abnormalities in 75 Cats With Systemic Hypertension
Authors: Henik Rosemary A. , Stepien Rebecca L. , Bortnowski Hattie B.
Published: September 2014

A retrospective study was performed in 75 hypertensive cats to determine the spectrum and frequency of M-mode echocardiographic abnormalities. Results indicated that 21.3% of the cats had M-mode measurements within normal reference ranges. For cats with echocardiographic abnormalities, changes were variable. Thirty-nine percent of hypertensive cats had hypertrophy of the interventricular septum in diastole, and 41.3% had hypertrophy of the left ventricular (LV) posterior wall in diastole. One cat in five had a dilated left atrium, while fractional shortening and LV internal dimension in diastole were normal in 82.7% and 86.7% of the cats, respectively. The marked variability of echocardiographic findings in hypertensive cats made echocardiography an unreliable screening test for hypertension.
Lactate as a Diagnostic Test for Septic Peritoneal Effusions in Dogs and Cats
Authors: Levin Garrett M. , Bonczynski Jennifer J. , Ludwig Lori L. , Barton Linda J. , Loar Andrew S.
Published: September 2014

Lactate concentration in peritoneal fluid was evaluated and compared to blood lactate concentration in dogs and cats with septic and nonseptic abdominal effusions. All dogs with septic effusions had a peritoneal fluid lactate concentration >2.5 mmol/L and a peritoneal fluid lactate concentration higher than blood lactate, resulting in a negative blood to fluid lactate difference. In dogs, the diagnostic accuracy of the peritoneal fluid lactate concentration and the blood to fluid lactate difference in differentiating septic peritoneal effusion was 95% and 90%, respectively. Peritoneal fluid lactate concentration and blood to fluid lactate difference were not accurate tests for detecting septic peritoneal effusions in cats.
Anemia Associated With ’Candidatus Mycoplasma haemominutum’ in a Feline Leukemia Virus-Negative Cat With Lymphoma
Authors: de Lorimier Louis-Philippe , Messick Joanne B.
Published: September 2014

’Candidatus Mycoplasma haemominutum,’ previously known as the small form of Haemobartonella felis (California species), is a hemotrophic parasite found on erythrocytes of infected cats. Although fleas are potential vectors, confirmatory studies are lacking. Healthy cats infected with ’Candidatus Mycoplasma haemominutum’ generally do not have clinically significant anemia, but concurrent disease or immune suppression may predispose a cat to develop a life-threatening anemia, such as in the case reported here.
Clinical Assessment of Disease Activity for Canine Inflammatory Bowel Disease
Authors: Jergens Albert E.
Published: September 2014

Clinical indices, consisting of gastrointestinal signs and laboratory parameters, are widely used for assessing disease activity in human inflammatory bowel disease (IBD). The development of a standardized scoring index for use in dogs with IBD would be useful in the management of clinical cases, both at diagnosis and in response to medical therapy. This review provides a synopsis of current strategies used to assess IBD activity in humans and companion animals. The clinical application of a simple scoring index (e.g., canine IBD activity index [CIBDAI]) for measurement of canine IBD activity is also reviewed.
Effect of a Single Plasma Transfusion on Thromboembolism in 13 Dogs With Primary Immune-Mediated Hemolytic Anemia
Authors: Thompson Mary F. , Scott-Moncrieff J. Catharine , Brooks Marjory B.
Published: September 2014

Thirteen dogs with primary immune-mediated hemolytic anemia received fresh-frozen plasma within 12 hours of admission, in addition to unfractionated heparin and other therapies, such as prednisone, azathioprine, and packed red blood cell transfusion. Antithrombin activity was quantified prior to transfusion and at 30 minutes and 48 hours after transfusion. Plasma antithrombin activity did not change significantly after a single plasma transfusion. There were no deaths in the first 48 hours of treatment. Thromboembolism was identified at necropsy in six of 10 dogs that died within 12 months of admission. There was no significant difference in the incidence of thromboembolism between the current treatment group and a historical control group.
Proximal Radial and Distal Humeral Osteosarcoma in 12 Dogs
Authors: Liptak Julius M. , Dernell William S. , Straw Rodney C. , Rizzo Scott A. , Lafferty Mary H. , Withrow Stephen J.
Published: September 2014

Twelve dogs were diagnosed with osteosarcoma of the proximal radius or distal humerus from 1990 to 2002, representing 1.0% of all dogs diagnosed with appendicular osteosarcoma. The median body weight (29.8 kg) was significantly less than that of dogs with appendicular osteosarcoma at other sites. Ten dogs were treated with amputation and chemotherapy. These dogs had a metastatic rate of 60%, a median metastasis-free interval of 356 days, and a median survival time of 824 days. There were no significant differences in metastasis-free interval or survival time between dogs with osteosarcoma of the proximal radius or distal humerus and dogs with appendicular osteosarcoma at other sites.
Aplastic Articular Facets in a Dog With Intervertebral Disk Rupture of the 12th to 13th Thoracic Vertebral Space
Authors: Werner Thorsten , McNicholas W. Thomas , Kim Jongmin , Baird Debra K. , Breur Gert J.
Published: September 2014

A 6-year-old, female spayed Pomeranian was presented with acute hind-limb paraplegia with the presence of deep pain perception and urinary incontinence. Myelography showed a Hansen type I herniation of the12th to 13th thoracic intervertebral space (T12–13). Articular facets of the T12–13 and T13 to first lumbar vertebra (L1) were absent. The spinal cord was decompressed using a bilateral T12–13 modified lateral hemilaminectomy (pediculectomy). The aplastic sites were associated with minimal instability of the vertebral column, and stabilization of the vertebral column was not required. Familiarity with this condition is important, because articular facet aplasia may cause vertebral instability and may require an adjusted surgical approach or vertebral reduction and fusion following decompression.
Diagnosis of Rapid Eye Movement Sleep Disorder With Electroencephalography and Treatment With Tricyclic Antidepressants in a Dog
Authors: Bush William W. , Barr Christina S. , Stecker Mark M. , Overall Karen L. , Bernier Noemie M. , Darrin Edwin W. , Morrison Adrian R.
Published: September 2014

A 9-month-old, female Labrador retriever mix was presented for two types of seizure-like episodes, one of which occurred only during sleep. The two types of episodes were morphologically distinct. An electroencephalogram (EEG) demonstrated that the sleep-associated episodes occurred during rapid eye movement (REM) sleep, supporting a diagnosis of a REM behavior disorder. Based on their morphology and response to antiseizure medications, the waking episodes were diagnosed as seizures. The animal was also diagnosed with an obsessive-compulsive and generalized anxiety disorder. The REM behavior disorder and anxiety-related behaviors improved with tricyclic antidepressant therapy.
Heart Failure Caused by Toxoplasmosis in a Fennec Fox (Fennecus zerda)
Authors: Kottwitz Jack J. , Preziosi Diane E. , Miller Margaret A. , Ramos-Vara Jose A. , Maggs David J. , Bonagura John D.
Published: September 2014

A male fennec fox (Fennecus zerda) kit was examined for lethargy, inappetence, and weight loss. Clinical findings included respiratory distress, a gallop rhythm, and retinochoroiditis. Radiography indicated pleural effusion and cardiomegaly. Echocardiographic findings included left ventricular dilatation, low left ventricular ejection fraction, and atrioventricular valvular regurgitation. Necropsy findings were compatible with a diagnosis of congestive heart failure caused by myocarditis. Histopathology showed a disseminated infection with Toxoplasma gondii causing myocarditis, skeletal polymyositis, gastrointestinal myositis, and panuveitis. Toxoplasma-induced myocarditis should be included in the differential diagnosis of heart failure and retinochoroiditis in the fennec fox.
Eastern Diamondback Rattlesnake (Crotalus adamanteus) Envenomation of Dogs: 31 Cases (1982–2002)
Authors: Willey Jonathan R. , Schaer Michael
Published: September 2014

The medical records of 31 dogs treated for envenomation by the Eastern Diamondback Rattlesnake (Crotalus adamanteus) were reviewed. Twenty-four of 25 dogs that survived were hospitalized for an average of 4.3 days. The most common presenting signs were tachycardia, swelling/edema, depressed mentation, tachypnea, and bleeding puncture wounds. Thirteen (42%) of the 31 dogs were presented with or developed cardiac arrhythmias, predominantly ventricular premature contractions. Hematological disorders, including defibrination, elevated fibrin split products, hemolytic anemia, thrombocytopenia, and prolonged clotting times, were recorded in 81% of the dogs. Polyvalent crotalid antivenin was administered (mean of 4.0 vials per dog) to 88% of the surviving dogs and 50% of the nonsurviving dogs.
Percutaneous Drainage and Alcoholization of Hepatic Abscesses in Five Dogs and a Cat
Authors: Zatelli Andrea , Bonfanti Ugo , Zini Eric , D’Ippolito Paola , Bussadori Claudio
Published: September 2014

Hepatic abscesses are rare and difficult to diagnose in dogs and cats. Ultrasonographic examination is essential to thoroughly examine hepatic abnormalities, and it may also help in the localization of hepatic abscesses. In this retrospective study, five dogs and one cat with focal hepatic lesions compatible with a hepatic abscess were treated with percutaneous ultrasound-assisted drainage and alcoholization using 95% ethanol. The procedure was performed rapidly under injectable anesthesia and provided excellent results in all animals. No complications or relapses were noted for 120 days following the procedure. The technique of percutaneous ultrasound-assisted drainage and alcoholization of hepatic abscesses in the dog and cat is also described.
Trends in the Frequency of Calcium Oxalate Uroliths in the Upper Urinary Tract of Cats
Authors: Lekcharoensuk Chalermpol , Osborne Carl A. , Lulich Jody P. , Albasan Hasan , Ulrich Lisa K. , Koehler Lori A. , Carpenter Kathleen A. , Swanson Laurie L. , Pederson Laura A.
Published: September 2014

Medical records from cats diagnosed with uroliths at nine United States veterinary teaching hospitals from 1980 to 1999, and records of cats with uroliths submitted for analyses to the Minnesota Urolith Center from 1981 to 2000, were evaluated. A 10-fold increase in frequency of upper tract uroliths occurred in cats during the 20-year interval at the nine veterinary teaching hospitals. Calcium oxalate emerged as the predominant mineral type in upper tract uroliths, having increased more than 50-fold during the study period. These results emphasize the need for increased awareness of the occurrence of upper urinary tract uroliths in cats.
Partial Foot Amputation in 11 Dogs
Authors: Liptak Julius M. , Dernell William S. , Rizzo Scott A. , Withrow Stephen J.
Published: September 2014

Eleven dogs with malignant tumors of the digits and feet were treated with partial foot amputation. Partial foot amputation involved amputation of one or both central weight-bearing digits. Lameness occurred in all dogs but resolved in eight dogs at a median of 37 days postoperatively. In the remaining three dogs, lameness improved but did not resolve. Tumor control was excellent, with no evidence of local recurrence in 10 dogs. One dog underwent limb amputation. Based on these results, partial foot amputation may be recommended in the management of malignant tumors of the canine foot in which more than one digit must be amputated to achieve adequate surgical margins.
Comparison of Normograde and Retrograde Intramedullary Pinning of Feline Tibias
Authors: Payne Justin , McLaughlin Ron , Silverman Edward
Published: September 2014

This study evaluated the effects of normograde and retrograde intramedullary pinning of mid-diaphyseal fractures of the feline tibia on the anatomical structures of the stifle joint. Using the paired pelvic limbs from five mature feline cadavers, a transverse, mid-diaphyseal osteotomy was performed, and each tibia was pinned in a normograde or retrograde fashion. The stifle joints were examined to determine the pin exit site and measure the distance from the exit site to pertinent anatomical structures of the stifle joint. Neither normograde nor retrograde intramedullary pinning resulted in damage to the cruciate ligaments, menisci, intermeniscal ligament, femoral condyles, or joint capsule. The patellar tendon was penetrated in all five tibias during retrograde pin insertion.
The Effects of Heated and Room-Temperature Abdominal Lavage Solutions on Core Body Temperature in Dogs Undergoing Celiotomy
Authors: Nawrocki Michael A. , McLaughlin Ron , Hendrix P. K.
Published: September 2014

To document the magnitude of temperature elevation obtained with heated lavage solutions during abdominal lavage, 18 dogs were lavaged with sterile isotonic saline intraoperatively (i.e., during a celiotomy). In nine dogs, room-temperature saline was used. In the remaining nine dogs, saline heated to 43±2°C (110±4°F) was used. Esophageal, rectal, and tympanic temperatures were recorded every 60 seconds for 15 minutes after initiation of the lavage. Temperature levels decreased in dogs lavaged with room-temperature saline. Temperature levels increased significantly in dogs lavaged with heated saline after 2 to 6 minutes of lavage, and temperatures continued to increase throughout the 15-minute lavage period.
Heinz Body Hemolytic Anemia With Eccentrocytosis From Ingestion of Chinese Chive (Allium tuberosum) and Garlic (Allium sativum) in a Dog
Authors: Yamato Osamu , Kasai Ei , Katsura Taro , Takahashi Shinichi , Shiota Takuji , Tajima Motoshi , Yamasaki Masahiro , Maede Yoshimitsu
Published: September 2014

A 4-year-old, intact male miniature schnauzer was presented with anorexia. The dog had ingested some Chinese steamed dumplings 2 days before, which contained Chinese chive (Allium tuberosum) and garlic (Allium sativum). Hematological examinations revealed severe Heinz body hemolytic anemia with eccentrocytosis and an increased concentration of methemoglobin, which was thought to result from oxidative damage to erythrocytes by constituents in these Allium plants. In this case, eccentrocytosis was a hallmark finding and could be detected easily, suggesting that this hematological abnormality is useful in diagnosing Allium plant-induced hemolysis.
Bilateral Stifle Osteochondritis Dissecans in a Cat
Authors: Ralphs S. Christopher
Published: September 2014

A 9-month-old, castrated male, domestic shorthaired cat was presented for progressive right hind-limb lameness. A diagnosis of osteochondritis dissecans of the lateral femoral condyle was made based on radiographs and physical examination, and was confirmed by right lateral stifle arthrotomy. The cartilage flap was removed, and the underlying bone was curetted. Seven months later, the cat was sound on the right leg but developed a left hind-limb lameness. A similar lesion was found in the left leg and was treated identically. Fourteen months after presentation, the cat was sound on both hind limbs.
AAHA Senior Care Guidelines for Dogs and Cats
Authors:   Senior Care Guidelines Task Force, Epstein Mark , Kuehn Ned F. , Landsberg Gary , Lascelles B. Duncan X. , Marks Steven L. , Schaedler Jean M. , Tuzio Helen
Published: September 2014

This paper provides a working framework for enhancing the well-being of senior pet dogs and cats. Approaches to screening the medical status of senior pets are described in detail, with particular emphasis on establishing baseline data in healthy animals, the testing of clinically ill animals, and assessing senior pets prior to anesthesia and surgery. The management of pain and distress and the application of hospice and palliative care are addressed. Advice on ways to approach euthanasia and dealing with end-of-life issues is also provided.
Evaluation of Extended-Release Diltiazem Once Daily for Cats With Hypertrophic Cardiomyopathy
Authors: Wall Michelle , Calvert Clay A. , Sanderson Sherry L. , Leonhardt Andrea , Barker Corrie , Fallaw Tiffany K.
Published: September 2014

Serum diltiazem concentrations were evaluated following either 30 mg or 60 mg of an extended-release diltiazem administered orally once daily to 13 cats. Sequential blood samples were obtained over 24 hours. Both dosages usually resulted in elevated serum concentrations of >200 ng/mL at 6, 12, 18, and 24 hours. The 30-mg dosage was sometimes associated with low serum concentrations of <50 ng/mL at 18 and 24 hours. The 60-mg dosage (9.3 to 14.8 mg/kg) was associated with lethargy, gastrointestinal disturbances, and weight loss in nine (36%) of 25 client-owned cats. Gastrointestinal disturbances were recognized within 1 week, and weight loss was detected after 2 to 6 months of treatment.
Necrotizing Fasciitis: A Review
Authors: Naidoo Sarah L. , Campbell Debbie L. , Miller Lisa M. , Nicastro Andrea
Published: September 2014

Necrotizing fasciitis is a rapidly spreading, bacterial, soft-tissue infection reported in both humans and dogs. A review of the pathophysiology, clinical findings, diagnosis, and treatment of necrotizing fasciitis is presented, with the goal of familiarizing veterinarians with this uncommon but potentially fatal condition. A case report highlighting the fulminant course of this disease is also included.
Feline Cutaneous Hemangiosarcoma: A Retrospective Study of 18 Cases (1998–2003)
Authors: McAbee Kevin P. , Ludwig Lori L. , Bergman Philip J. , Newman Shelly J.
Published: September 2014

Cutaneous hemangiosarcoma (HSA) has been infrequently reported in dogs and cats. Medical records of 18 cats diagnosed with cutaneous HSA were reviewed. Age at the time of diagnosis, breed, sex, tumor location, tumor size, treatment type, survival time, disease-free interval, and cause of death were evaluated. Aggressive surgical excision of the tumor was attempted in 10 cats. A complete surgical excision was achieved in five of the 10 cats. Median survival times were statistically longer in cats that underwent surgery versus cats that did not. Cats with cutaneous HSA treated with aggressive surgical excision of their tumors may have a good long-term prognosis.
Relationship Between Age and Tibial Plateau Angle in Dogs With Cranial Cruciate Rupture
Authors: Zeltzman Philippe A. , Paré Bernard , Johnson Gretchen M. , Zeltzman Valérie , Robbins Mitchell A. , Gendreau Claude L.
Published: September 2014

The pathogenesis of cranial cruciate ligament (CCL) rupture remains controversial, and its relationship to tibial plateau angle is unknown. In this study, the tibial plateau angle was measured in 200 large-breed dogs diagnosed with CCL rupture. Correlation analyses were performed to determine whether the age at the time of CCL rupture and the tibial plateau angle were related. While these two values were inversely correlated, the relationship was not strong enough to explain the frequency of CCL rupture in young, large-breed dogs. There was no statistically significant correlation between age at the time of CCL rupture and tibial plateau angle.
Arthroscopic Biceps Tenodesis: Technique and Results in Six Dogs
Authors: Cook James L. , Kenter Keith , Fox Derek B.
Published: September 2014

Biceps tenodesis was performed using an arthroscopic-assisted technique on six dogs diagnosed with chronic bicipital tendon pathology. The technique was performed using two different fixation methods (i.e., cannulated interference screw, cannulated screw and tissue washer). All six dogs had successful outcomes in terms of return to full function at a mean follow-up time of 11.7 months after surgery. Arthroscopic biceps tenodesis is a feasible option for surgical management of biceps tendon pathology, and it may have advantages over open tenodesis and open or arthroscopic tenotomy. Further study is needed before definitive recommendations regarding indications, complications, and prognosis associated with arthroscopic biceps tenodesis can be made.
Use of the D-dimer Assay for Diagnosing Thromboembolic Disease in the Dog
Authors: Nelson O. Lynne
Published: September 2014

Although the exact incidence of pulmonary thromboembolism (PTE) in small animals is unknown, it is thought that PTE is a substantial, under-diagnosed complication. The difficulty in diagnosing PTE in small animals is confounded by its subtle symptomatic presentation and a lack of clinical suspicion, coexisting disease states, and lack of noninvasive tests that are sensitive and specific for the diagnosis of PTE. Although numerous laboratory markers of coagulation have been studied, only the D-dimer assay has shown clinical utility in detecting early embolism in humans. This paper examines the use of D-dimer assays and other clinical modalities in the diagnostic approach to thromboembolic disease in small animals.
Spontaneous Chronic Corneal Epithelial Defects in Dogs: A Review
Authors: Bentley Ellison
Published: September 2014

Spontaneous chronic corneal epithelial defects (SCCEDs) in dogs are typically found in middle-aged dogs of all breeds. These epithelial defects may be present for weeks to months, particularly if left untreated or if treated inappropriately. Typical histopathological findings include loss of the corneal epithelial basement membrane and formation of a superficial, acellular, hyalinized zone in the stroma. Together, these histological abnormalities lead to delayed wound healing and poor epithelial adhesion. Epithelial debridement, anterior stromal puncture, grid keratotomy, and superficial keratectomy are the most common treatment options applied to the defects. Procedures that address the stromal changes present generally have a higher success rate than epithelial debridement alone.
Clinical Features of Epistaxis in Dogs: A Retrospective Study of 35 Cases (1999–2002)
Authors: Strasser Jennifer L. , Hawkins Eleanor C.
Published: September 2014

Epistaxis was retrospectively evaluated in 35 dogs. Systemic disease was diagnosed in seven dogs and intranasal disease in 29. Nineteen dogs with intranasal disease had neoplasia. Dogs with neoplasia were older (mean 10.0 years) than dogs with nonneoplastic intranasal disease (mean 5.6 years). Signs persisting for >1 month occurred more often in dogs with intranasal than systemic disease. Unilateral epistaxis did not distinguish intranasal from systemic disease. Only dogs with intranasal disease had facial deformity, decreased airflow, or regional sub-mandibular lymphadenopathy. Dogs with systemic disease had a lower packed cell volume (mean 31.8%) than dogs with intranasal disease (mean 42.7%).
Use of a New Investigational Interlocking Nail Supplement in the Repair of Comminuted Diaphyseal Tibia Fractures in Two Dogs
Authors: Nanai Beatrix , Basinger Randy R.
Published: September 2014

Two dogs were diagnosed with highly comminuted diaphyseal tibial fractures following traumatic incidents. Investigational hybrid interlocking nail (ILN) bolt/external skeletal fixator (ESF) pins were used to repair both fractures. The surgery was successful, and fractures healed without complications by 6 weeks (case no. 1) and 17 weeks (case no. 2) after surgery. This article describes the application and the advantages of a new, investigational ILN supplement that was specifically designed to accomplish initial rigid stability and allow progressive destabilization to the fracture repair. The authors are continuing to study the biomechanical properties of this procedure in order to accurately establish clear recommendations for its use in certain fracture situations.
Cytotoxic Chemotherapy: New Players, New Tactics
Authors: Vail David M. , Thamm Douglas H.
Published: September 2014

Veterinary clients often seek the same new and innovative cancer treatment options for their companion animals that they read about in the press or on the Internet. It is, therefore, necessary for the practitioner to have an understanding of the development of new and innovative cytotoxic drugs and delivery techniques. This article describes the drug development process and how a new product eventually finds its way into clinical use. Some of the newer drugs and delivery techniques applied to small animals are reviewed.
The Use of Carbon Dioxide Laser for the Ablation of Meibomian Gland Adenomas in Dogs
Authors: Bussieres Martin , Krohne Sheryl G. , Stiles Jean , Townsend Wendy M.
Published: September 2014

Twelve eyelid meibomian gland adenomas in dogs were surgically ablated using the carbon dioxide (CO2) laser. The laser site was not sutured. All procedures resulted in complete removal of the adenoma with no recurrences at 6 months. In addition, no dogs developed corneal disease secondary to the procedure, and the cosmetic appearance of the eyelid margins was good at the end of the 6-month study. Based on results of this study, CO2 laser ablation of canine meibomian gland adenomas is an effective alternative to standard surgical removal.
Myasthenia Gravis and Hypothyroidism in a Dog With Meningomyelitis
Authors: Levine Jonathan M. , Bergman Robert L. , Coates Joan R. , Shelton G. Diane
Published: September 2014

A 12-year-old, spayed female miniature poodle was evaluated because of a 4-day history of paraparesis, dysuria, and tenesmus. Neurological assessment suggested peripheral nervous system dysfunction, predominantly pelvic limb weakness with a possible concurrent sixth lumbar (L6) to second sacral (S2) myelopathy. Further studies supported the diagnoses of myasthenia gravis, hypothyroidism, and meningomyelitis. To the authors’ knowledge, this is the first reported case of concurrent myasthenia gravis and meningomyelitis in the dog. It was unclear whether the identified conditions evolved from a shared etiopathogenesis or were merely coincidental.
Vascular Encephalopathy Associated With Bacterial Endocarditis in Four Dogs
Authors: Cook Laurie B. , Coates Joan R. , Dewey Curtis W. , Gordon Sonya , Miller Matthew W. , Bahr Anne
Published: September 2014

Vascular encephalopathy is a commonly encountered clinical complication of infectious endocarditis in humans, but it has been infrequently reported in dogs. A series of four dogs with bacterial endocarditis that subsequently developed acute onset of neurological deficits is described. Clinical signs, diagnostic test results, and outcomes for each case are presented and compared with the human clinical syndrome.
Central Nervous System Dysfunction Associated With Rocky Mountain Spotted Fever Infection in Five Dogs
Authors: Mikszewski Jessica S. , Vite Charles H.
Published: September 2014

Five dogs from the northeastern United States were presented with clinical signs of neurological disease associated with Rocky Mountain spotted fever (RMSF) infection. Four of the five dogs had vestibular system dysfunction. Other neurological signs included paresis, tremors, and changes in mentation. All of the dogs had an elevated indirect fluorescent antibody titer or a positive semiquantitative enzyme screening immunoassay titer for Rickettsia rickettsii at the time of presentation. Although a higher mortality rate has been reported for dogs with neurological symptoms and RMSF infection, all of the dogs in this study improved with appropriate medical therapy and supportive care.
Surgical Management of Combined Hydrocephalus, Syringohydromyelia, and Ventricular Cyst in a Dog
Authors: Hasegawa Takashi , Taura Yasuho , Kido Hiroshi , Shibazaki Akira , Katamoto Hiromu
Published: September 2014

Combined hydrocephalus, syringohydromyelia, and a ventricular cyst were found by magnetic resonance imaging in a 7-month-old, male miniature dachshund with gait abnormalities and altered mentation. Clinical signs did not improve with prednisone therapy. Ventriculoperitoneal shunting improved the clinical signs and anatomical abnormalities. Repeated operations were needed to replace the ventricular drainage tube at 3 and 31 months after the first surgery. The animal died suddenly with severe tonic-clonic, generalized seizures 3 weeks after the third operation. Ventriculoperitoneal shunting may be a viable treatment for syringohydromyelia associated with hydrocephalus.
Nutritional Myths
Authors: Wortinger Ann
Published: September 2014

Owners are sometimes confused or misinformed about nutritional facts pertaining to pet foods, and three common nutritional myths have been propagated in the popular press. The first myth is that meat by-products are of inferior quality compared to whole meat. The second myth is that feeding trials are unnecessary, and the third myth is that pet food preservatives are bad. This paper examines the known facts related to these three myths and discusses the importance of food trials and the different classes and forms of antioxidants used in pet foods.
Taurine-Deficient Dilated Cardiomyopathy in a Family of Golden Retrievers
Authors: Bélanger Marie C. , Ouellet Mathieu , Queney Guillaume , Moreau Maxim
Published: September 2014

A reversible taurine-deficient dilated cardiomyopathy occurred in five related golden retrievers. An apical systolic heart murmur was the most common physical abnormality. According to fractional shortening and end-systolic diameter on echocardiography, significant improvements (P<0.005) were recorded within 3 to 6 months of starting taurine supplementation. The dogs regained substantial systolic function, and four were weaned off all cardiac medications except taurine. This response to therapy was unusual, because canine dilated cardiomyopathy is generally progressive and fatal.
Feline Acromegaly: A Review of the Syndrome
Authors: Hurty Charles A. , Flatland Bente
Published: September 2014

Acromegaly is characterized by chronic excessive growth hormone (GH) secretion by the pituitary gland. Feline acromegaly is most commonly caused by a functional pituitary tumor. Definitive diagnosis can be difficult because of the gradual disease onset, subtle clinical signs, unavailability of relevant laboratory tests, and client financial investment. The most significant clinical finding of acromegaly is the presence of insulin-resistant diabetes mellitus. Diagnosis is currently based upon brain imaging and measurement of serum GH and/or insulin-like growth factor-1 concentrations. Definitive treatment in cats is not well described, but radiation therapy appears promising.
Laryngeal, Laryngotracheal, and Tracheal Masses in Cats: 27 Cases (1998–2003)
Authors: Jakubiak Martin J. , Siedlecki Cecile T. , Zenger Elisabeth , Matteucci Mark L. , Bruskiewicz Kristine A. , Rohn Douglas A. , Bergman Philip J.
Published: September 2014

Medical records of 27 cats with masses of the larynx and trachea were examined. Six cats had inflammatory masses, and 21 cats had neoplastic lesions. A definitive diagnosis was reached in 22 cats with a single biopsy. The median age of the cats was 12.0 years (range 6 to 20 years). Dyspnea was the most common clinical sign. Accurate diagnoses were best obtained through direct laryngeal or tracheal examination combined with histological examination of tissue biopsies. Kaplan-Meier survival data for all inflammatory and neoplastic lesions showed a median survival of 5 days, with 7.4% of cats alive at 1 year.
Acute Granulocytic Ehrlichiosis in a Rottweiler
Authors: Arsenault Wendy G. , Messick Joanne B.
Published: September 2014

Acute granulocytic ehrlichiosis was identified in a 6-year-old rottweiler that was presented for possible pancreatitis. Intracytoplasmic inclusion bodies were identified within neutrophils on a peripheral blood smear. Serology was ineffective in identifying the disease in the acute state. The diagnosis and identification of the organism were confirmed by polymerase chain reaction (PCR) and deoxyribonucleic acid (DNA) sequencing. Based on elevations in amylase and lipase and the presence of right cranial-quadrant abdominal pain, concurrent pancreatitis was diagnosed. It is unknown if there was any association between the acute granulocytic ehrlichiosis and the pancreatitis. The dog recovered well following doxycycline therapy.
Moving Toward Interdisciplinary Pain Management
Authors: Downing Robin
Published: September 2014

Pain is an unpleasant and emotional experience associated with actual or potential tissue damage. The current method of caring for a person with multiple issues and problems is a "multidisciplinary" approach; however, the disadvantages of a multidisciplinary approach are many. A more desirable alternative is an "interdisciplinary" approach. Interdisciplinary care is predicated on professionals communicating with one another about a single patient and designing care that is in the overall best interest of the patient. This paper describes the formation of the International Veterinary Academy of Pain Management, whose objective is to promote the interdisciplinary approach to animal pain management.