bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of cardiac remodeling in patients with hypertension of different ethnic groups
Authors: Abramov E A , Nevzorova V A , Repina N I
Published: February 2021

Objective. To study the features of different types of left ventricles (LV) geometry in patients with essential hypertension (EH) of different ethnic groups. Materials and methods. We examined 180 patients, residents of the Sakhalin Region, with 1-3 degree arterial hypertension, including 88 patients of Korean ethnicity aged from 45 to 63 years (mean age - 59.2±0.86 years) and 92 patients of Slavic ethnicity in age from 43 to 64 years (mean age - 58.2±0.93 years). LV structural and functional characteristics were studied by means of echocardiography with Doppler analysis on the ultrasonic system Acuson X300 (HP, USA). Results. The results of assessment of different types of LV geometry revealed the following differences: prevalence of the LV concentric remodeling was higher in patients with EH of Korean ethnicity (21.5% versus 13% among the Slavs, p=0.04). Conclusion. The study of the structural characteristics of left ventricular in patients with hypertension, residents of the Sakhalin Region, revealed that concentric remodeling and concentric left ventricular hypertrophy are the main types of LV geometry in hypertensive patients of both ethnic groups. However, concentric LV remodeling was more often detected in patients with hypertension of Korean ethnicity.
Pharmacological therapy, slows the heart rate, in patientswith hypertension and chronic heart failure: theory and application in clinical practice
Authors: Ponomareva A I , Kompaniets O G , Linchak R M , Ivanchura G S
Published: February 2021

The purpose of the study is to determine the spectrum used drugsslows the heart rate in patients with arterial hypertension and chronic heart failure in clinical practice and compliance of prescribing with clinical guidelines.Materials and methods. Consistently formed a retrospective sample of medical records of patients with arterial hypertension and chronic heart failure. Used sources of primary medical documentation for 2012-2015 (320 patients). Estimated the amount and quality therapyslows the heart ratein patients with arterial hypertension and chronic heart failure.Results and discussion. b-blockers prescribed for 72.5% of patients. Calcium antagonists range recommended by 13.1%. On the background of optimal doses of b-blockers in patients with arterial hypertension and chronic heart failure with the exile faction of less than 40 and heart rate more than 70 BPM, ivabradine is not assigned in 81.3% of patients, although it is in these situations of particular urgency is the drug given its bright positive effect on hard end points, proved in international multicenter trials.
Coagulation markers in patients with obstructive sleep apnea syndrome and effects of continuous positive airway pressure
Authors: Bugaev T D , Elfimova E M , Ageeva N V , Dobrovolskiy A B , Litvin A Yu
Published: February 2021

The aim of our study is to determine association between obstructive sleep apnea (OSA) syndrome and levels of blood coagulation markers and evaluate possible effects of continuous positive airway pressure (CPAP) therapy. Materials and methods. We included 74 middle-aged (mean age 48 [40; 55] years) male patients with arterial hypertension (AH) of average duration 8 [5; 10] years without antiplatelet, anticoagulant therapy and diabetes mellitus. All patients underwent sleep breathing study. According to the severity of OSA, patients were divided into 2 groups: 40 patients with severe OSA - apnea/hypopnea index - AHI 50.2 (37.8; 75.2) and control group with 34 patients with mild or no OSA - AHI 4.8 (2.6; 7.8). In all patients were analyzed markers of hemostasis system and parameters of whole blood viscosity; 34 patients with severe OSA underwent 3-4 nights of effective CPAP therapy (with achievement AHI
Clinical efficacy of sympathetic denervation of renal arteries in patients with resistant arterial hypertension as part of annual prospective follow-up
Authors: Gapon L I , Mikova E V , Savelyeva N Yu , Kolunin G V , Zherzhova A Yu
Published: February 2021

Objective. To study the clinical efficacy of sympathetic denervation of the renal arteries (RDN RA) in patients with resistant arterial hypertension (AH). Materials and methods. The study included 34 patients with resistant AH aged 27 to 70 years. Criteria for inclusion in the research: a resistant course of AH with a level of arterial pressure (BP) >160/100 mm Hg. Art. (With a diuretic) at optimal doses, the preserved renal function (glomerular filtration rate >45 ml/min) and the absence of a secondary form of AH, written informed consent. Results. RDN PA contributed to statistically significant A decrease in both office and average daily SBP and DBP, a clinical hypotensive effect was observed in men and women, however, in the night hours there was a more significant decrease in SBP in women. Conclusions. A prospective one-year observation confirmed a long-term Efficiency RDN RA in the treatment of patients with refractory hypertension.
A new fixed combination of perindopril, indapamide and amlodipine. "Three in one" is the way to improve the results of arterial hypertension treatment
Authors: Temnikova E A
Published: February 2021

The management of patients with arterial hypertension is a difficult problem even if use the modern antihypertensive drugs. The reasons of the inadequate control to arterial pressure level during the treatment are different. The application fixed combinations of antihypertensive drugs improves the results of therapy, weigh with separate pathogenetic mechanisms of blood pressure increasing and the counterregulatory effects of the treatment each components of the combination. The use of fixed combinations significantly increases patient adherence to treatment. A new fixed triple combination of perindopril, indapamide, amlodipine expands therapeutic options for the treatment arterial hypertension. The effectiveness of the use of each of the components and their combination is proved in large international studies.
Clinical Manual for Diagnosis, Prevention and Treatment of Cardiovascular Complications of Cancer Therapy. Part I
Authors: Chazova I Ye , Tyulyandin S A , Vitsenia M V , Ovchinnikov A G , Poltavskaya M G , Gilyarov M Yu , Martynyuk T V , Panchenko E P , Fedotkina Yu A , Stenina M B , Trophimova O P , Ageev F T
Published: February 2021

Advances in treatment have led to improved survival of patients with cancer but have also resulted in untoward side effects associated with treatment. Cardiovascular diseases are one of the most frequent of these side effects. Myocardial dysfunction and heart failure, myocardial ischaemia, arrhythmias, arterial hypertension, thromboembolic disease and other cardiovascular complications can interfere with the efficacy of treatment, decrease quality of life, or impact the actual survival of the patient with cancer. This manual discusses concepts for timely diagnosis, intervention, and surveillance of patients treated with cardiotoxic cancer therapies. In this first part оf manual we discuss the diagnostic, prevention and treatment aspects of cancer therapy-related cardiac dysfunction and heart failure.
The new angiotensin II receptor blocker Edarbi® as part of the pathogenetic treatment of arterial hypertension in patients with metabolic disorders
Authors: Chazova I Ye , Zhernakova Yu V , Blinova N V , Rogoza A N
Published: February 2021

Relevance. Recently, the proportion of angiotensin receptor blockers has significantly increased among prescribed antihypertensive drugs. High organoprotective properties, additional metabolic effects and tolerability comparable to placebo make them the drugs of choice, especially in patients with stage 1 and stage 2 hypertension having low adherence to antihypertensive therapy, but already burdened by additional metabolic risk factors. Purpose of the study - study of the antihypertensive efficacy of the angiotensin receptor blocker azilsartan medoxomil (Edarbi®), its effect on cardiometabolic risk factors and damage of target organs in patients with stage 2 hypertension. Materials and methods. The study included 32 patients (mean age 47.32±8.4 years), 19 men and 13 women with stage 2 hypertension. All patients were evaluated for clinical blood pressure (BP), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, creatinine, glucose level in a carbohydrate tolerance test, 24-hour blood pressure monitoring, central aortic systolic pressure, сarotid-femoral pulse wave velocity and intima-media thickness was determined initially and after 6 months of therapy. Results. During taking Edarbi® 82% of patients with stage 1 and stage 2 hypertension and metabolic syndrome reached the target level of BP, which was accompanied by a significant improvement in diastolic function of the left ventricle in 56% of patients. Already in the first 6 months the treatment reduced arterial stiffness and improved metabolic control
The efficacy and safety of torasemid in the treatment of arterial hypertension in different clinical situations
Authors: Ostroumova O D , Piksina G F , Smolyarchuk E A , Pavleeva E E , Bondarets O V
Published: February 2021

The article considers issues of efficiency and safety of the use of torasemid, a loop diuretic, with the additional property of antagonist of the mineralocorticoid receptor in the treatment of arterial hypertension in different groups of patients.
Calcineurin inhibitors and arterial hypertension in recipients of solid organs
Authors: Kosmacheva E D , Martirosyan S M , Lepshokova M Kh , Babich A E
Published: February 2021

Arterial hypertension is an established risk factor for cardiovascular complications. Since the introduction of calcineurin inhibitors (CNI), аrterial hypertension is observed in 50-80% of transplanted patients. Arterial hypertension and transplantation are closely linked, and its association may promote impaired graft and overall survival. We summarize the main mechanisms involved in the genesis of CNI-induced hypertension as follows: impaired renal function with the sodium retaining, endothelial dysfunction, renin-angiotensin-aldosterone system and sympathetic activation, production of vasoconstrictor substances, activation the renal Na+/Cl--cotransporter. Attention is focused on the dose-dependent increase in arterial pressure and the need for further study of the intensity of the pro-hypertensive effect of various calcineurin inhibitors.
Prevalence, awareness and adherence to treatment of arterial hypertension: myths and reality
Authors: Krivoshapova K E , Tsygankova D P , Barbarash O L
Published: February 2021

This review analyzes and summarizes the results of major epidemiological studies aimed at assessing the prevalence of arterial hypertension, one of the most significant cardiovascular risk factors according to the socioeconomic factors (the ESSE study, the PURE study). Comparative characteristics of both the prevalence of arterial hypertension and the level of awareness among the population about the presence of arterial hypertension, adherence to treatment and control of blood pressure among residents of countries with different socio-economic levels are given. We concluded that despite the implementation of preventive measures, the gap between the diagnosis of arterial hypertension, the subsequent control of blood pressure and adherence to treatment in most countries remains rather large. This indicates the need for a more thorough analysis of possible causes and the development of new preventive measures.
Atherosclerotic stenos of renal arteries at patients with diabetes mellitus and arterial hypertension.
Authors: Fomin Viktor Viktorovich , Moiseev Sergey Valentinovich , Shvetsov Mikhail Yur'evich , Mukhin Nikolay Alekseevich
Published: February 2021

Problems of diagnostics and treatment of ischemic renal disease (atherosclerotic stenosis of renal arteries) at patients with diabetes mellitus
are discussed.
The use of angiotensin receptor blocker losartan in the combinational therapy of arterial hypertension
Authors: Zagidullin N Sh , Zagidullin Sh Z
Published: February 2021

Blockade of renin-angiotensin systems is one problem in the treatment of arterial hypertension. Resistant hypertension and patients with high cardiovascular
risk demand frequently use of combination therapy. The efficiency of combined therapy losartan plus hydrochlorothiazide at patients
with arterial hypertension was studied in several large clinical multicentre randomized studies. It is proved high efficiency and safety of this combination
therapy.
Contraindications and adverse events of drugs in cardioneurological patients.
Authors: Kompaniets Ol'ga Gennadievna
Published: February 2021

In our days big attention is drawn to safe drug therapy. It importance is associated with great prevalence of medical products side
effects and consequences, high economic expenses for their correction. Knowing specific features of adverse drug reactions in different
groups of patients it could be possible to decrease their prevalence and magnitude.
Arterial hypertension in the elderly and higher mental functions. Possibilities of an-tihypertensive therapy withArifon retard in the prevention of dementia.
Authors: Ostroumova Ol'ga Dmitrievna , Korsakova Natal'ya Konstantinovna , Varako Natal'ya Aleksandrovna
Published: February 2021

Low-dose thiazide and thiazide-like diuretics (indapamide retard) are the drugs of choice in the treatment of elderly patients with arterial hypertension (AH), including isolated systolic AH (ISAH). The problem of treatment of AH in elderly patients is associated with that of vascular dementia. Despite the fact that AH is a major risk factor in the development and progression of dementia, its impact on higher mental functions in patients, including geriatric ones, has been little studied to the present day. The paper also gives the results of Syst-Eur and HYVET clinical trials. The results of the authors\' investigation are also presented. Twenty-six elderly patients (aged 60-74 years; mean age 65.2+5.9 years) with untreated or ineffectively treated grades 1-2 essential AH (mean disease duration 17.3+5.6 years) were examined; women were 84.6%; patients with ISAH and those with grade 1 AH were 70,8 and 84.6%, respectively. The patients were given the diuretic indapamide retard (Arifon retard, (Servier, France) in a dose of 1.5 once daily in the morning; the follow-up was 24 weeks. Physical examination, routine blood pressure (BP), 24-hour BP monitoring, and neuropsychological study, as described by A.R. Lu-ria, were conducted. Following 24-week treatment, there was a significant reduction in both di-urnal and nocturnal systolic and diastolic BP. After the performed treatment, there was a signifi-cant visual-logistic improvement (p
OVERCOMING STRATEGIES AND TOLERANCE TO UNCERTAINTY OF STUDENTS OF SENIOR CLASSES
Authors: Джабарова Оксана Эриковна
Published: February 2021

Представлены результаты проведенного эмпирического исследования по проблеме стратегий преодоления и толерантность к неопределенности учащихся старших классов. С помощью полученных данных в исследовании выявлена взаимосвязь стратегий преодоления и толерантность к неопределенности учащихся старших классов. Выявлены значимые положительные связи толерантности к неопределенности и стратегий преодоления - например, прямая связь с конструктивной стратегией преодоления «поиск социальной поддержки».

Presents the results of empirical a study on coping strategies and tolerance for uncertainty in high school students. Using the data obtained, the study revealed the relationship between coping strategies and tolerance for uncertainty in high school students. Significant positive relationships of tolerance to uncertainty and coping strategies have been identified, for example, a direct relationship with the constructive coping strategy «search for social support».
TRENDS IN SCHOOL GEOGRAPHICAL EDUCATION IN THE CONTEXT OF ECOCENTRIC CONSCIOUSNESS AMONG STUDENTS
Authors: Чернятин Максим Сергеевич
Published: February 2021

Представлен структурно-содержательный анализ Концепции школьного географического образования в Российской Федерации; рассматриваются тенденции развития школьной географии в контексте формирования у учащихся экоцентрического сознания; отражены ключевые идеи, способствующие формированию вышеуказанного типа сознания в процессе изучения географии в школе на личностном, метапредметном и предметном уровнях.

In article presents a structural and meaningful analysis of the Concept of School Geographical Education in the Russian Federation; consideration is given to trends in the development of school geography in the context of the formation of ecocentric consciousness among pupils; key ideas contributing to the formation of the above-mentioned type of consciousness in the process of studying geography in school at the personal, metasubject and subject levels are reflected.
REALIZATION OF A PROFESSIONAL ORIENTATION OF MATHEMATICAL TEACHING AT TECHNICAL UNIVERSITY
Authors: Филатов Владимир Викторович , Гобыш Альбина Владимировна
Published: February 2021

Рассмотрены вопросы профессиональной направленности преподавания математических дисциплин в техническом вузе, актуальность которых обусловлена внедрением новых образовательных стандартов. Проведён анализ научных публикаций по данной тематике и обобщён педагогический опыт авторов. Обоснованы преимущества использования профессионально-ориентированных математических задач в сочетании с электронными образовательными ресурсами в учебном процессе. Приведены примеры задач профессионального характера по математическим дисциплинам и установлены межпредметные связи для ряда образовательных программ, реализуемых в Новосибирском государственном техническом университете.

The issues of the applied orientation of teaching mathematical disciplines at university are considered, the relevance of which is due to the introduction of new educational standards. The analysis of scientific publications on this topic is carried out and the pedagogical experience of the authors is generalized. The advantages of using professionally oriented mathematical problems in combination with electronic educational resources in the educational process are substantiated. Examples of applied problems on mathematical subjects are given and interdisciplinary connections are established for a number of educational programs implemented at Novosibirsk State Technical University.
SYNTACTIC ERROR IN THE PRACTICE OF TEACHING RUSSIAN AS A FOREIGN LANGUAGE
Authors: Цховребов Алан Солтанович
Published: February 2021

Рассматриваются тенденции развития лингводидактической теории синтаксической ошибки в практике преподавания русского языка как иностранного в современной педагогической практике. Изучены проблемы лингводидактической теории синтаксических ошибок в речи иностранных обучающихся, анализируется проблема квалификации и классификации синтаксических ошибок в методике преподавания РКИ, выявляются причины возникновения ошибок и предлагаются пути устранения указанных речевых нарушений. Анализ литературы по исследуемой проблеме показал, что исследователи используют термины «типичные и нетипичные ошибки», «коммуникативно значимые и коммуникативно незначимые ошибки» и квалифицируют их как нарушения, связанные с неправильным употреблением падежа, словоформы, а также ошибки на уровне синтаксической структуры предложения. Установлено, что в результате влияния родного языка на иностранный появляются как типичные (отклонения от нормы, которые проявляются в результате взаимодействия разных языков), так и нетипичные ошибки. Таким образом, при разработке методики педагогического воздействия следует принять за основу принцип учета особенностей родного языка обучающихся, позволяющий при дифференциальных языковых явлениях опираться на родной язык с целью прогнозирования интерферирующих ошибок.

The article considers the trends of development of the linguodidactic theory of syntactic error in the practice of teaching Russian as a foreign language in modern pedagogical practice. The problems of the linguo-didactic theory of syntactic errors in the speech of foreign students are studied, the problem of qualification and classification of syntactic errors in the teaching methodology of RCI is analyzed, the causes of errors are identified and ways to eliminate these speech disorders are proposed. Analysis of the literature on the problem under study has shown that researchers use the terms "typical and atypical errors", "communicatively significant and communicatively insignificant errors" and classify them as violations associated with the incorrect use of case, word form, and errors at the level of the syntactic structure of the sentence. It is established that as a result of the influence of the native language on the foreign language, both typical (deviations from the norm that are manifested as a result of the interaction of different languages) and atypical errors appear. Thus, when developing a method of pedagogical influence, it is necessary to take as a basis the principle of taking into account the peculiarities of the native language of students, which allows for differential language phenomena to rely on the native language in order to predict interfering errors.
La relación espiritual del pueblo warao con Dani jobai
Authors: Vallejo Infante Henry Rafael
Published: February 2021

En este artículo se establece una narración que hilvana diversos estudios sobre el pueblo warao a fin de avanzar en el entendimiento del imaginario que sustenta las formas de vivir, pensar y proyectar la relación espiritual de la mujer indígena con la Madre Tierra. El interés principal del estudio es identificar las milenarias prácticas migratorias del grupo étnico, como resultado de su cosmovisión, para así superar la mirada colonialista y punitiva con la que se pretende juzgar los desplazamientos poblacionales de los aborígenes por las extensiones orinoquenses, amazónicas y caribeñas. Se desarrolla un eje temático decolonialista desde los postulados de Palermo (s/f), Bigott (2011) y Lepe-Carrión (2014), centrado en la denuncia de los abusos del sistema capitalista y la dignificación de los saberes orales para reconstruir la historia de la milenaria población, fundamentados desde los planteamientos de Betancourt (1999), Ayala y Wilbert (2012), y Dieter (2008). Por ser una investigación de carácter etnográfico; se asumen las orientaciones metodológicas de LeComte & Goetz (1982), en coherencia con el paradigma socioconstruccionista planteado por Wiesenfeld (2001); para desarrollar la interpretación de los testimonios orales recogidos mediante la entrevista cualitativa se toma como referente a Márquez (2006 y 2009). En cuanto a los aportes finales para la construcción epistémica, se logró evidenciar el tejido multidimensional que fundamenta los vínculos espirituales de compensación, amor y honra por sus ancestros, Dani Jobai, el Gran Kanabo y los seres cósmicos y selváticos del territorio.
Peak External Intensity Decreases across Quarters during Basketball Games
Authors: Fox Jordan L. , Salazar Hugo , Garcia Franc , Scanlan Aaron T.
Published: February 2021

The purpose of this study was to compare peak external intensities across game quarters in basketball. Eight semi-professional male players were monitored using accelerometers. For all quarters, peak intensities were determined via moving averages for PlayerLoad/minute (PL·min-1) using sample durations of 15 s, 30 s, 1 min, 2 min, 3 min, 4 min, and 5 min. Linear mixed models and effect sizes (ES) were used to compare peak intensities between quarters for each sample duration. Small decreases in peak PL·min-1 occurred between Quarters 1 and 4 for all sample durations (ES = 0.21-0.49). Small decreases in peak PL·min-1 were apparent between quarters 1 and 2 for 30-s, 1-min, and 3-min sample durations (ES = 0.24-0.33), and between quarters 3 and 4 for 2-5-min sample durations (ES = 0.20-0.24). Peak intensities decline across quarters with game progression in basketball, providing useful insight for practitioners to develop game-specific training and tactical strategies.
Accuracy in Archery Shooting is linked to the Amplitude of the ERP N1 to the Snap of Clicker
Authors:   Eskisehir Technical University, Faculty of Sport Sciences, Department of Coaching Education, Eskisehir, Turkey, Ertan Hayri , Yagcioglu Suha ,   Hacettepe University, Medical School, Biophysics Department, Ankara, Turkey, Yılmaz Alpaslan ,   Erciyes University, Faculty of Sport Sciences, Department of Coaching Education, Kayseri, Turkey, Ungan Pekcan ,   Koc University, Medical School, Istanbul, Turkey, Korkusuz Feza ,   Hacettepe University, Medical School, Department of Sports Medicine, Ankara, Turkey
Published: February 2021

An archer requires a well-balanced and highly reproducible release of the bowstring to attain high scores in competition. Recurve archers use a mechanical device called the “clicker” to check the draw length. The fall of the clicker that generates an auditory stimulus should evoke a response in the brain. The purpose of this study is to evaluate the event-related potentials during archery shooting as a response to the fall of the clicker. Fifteen high-level archers participated. An electro cap was placed on the archers’ scalps, and continuous EEG activity was recorded (digitized at 1000 Hz) and stored for off-line analysis. The EEG data were epoched beginning 200 ms before and lasting 800 ms after stimulus marker signals. An operational definition has been developed for classifying hits corresponding to hit and/or miss areas. The hit area enlarged gradually starting from the centre of the target (yellow: 10) to blue (6 score) by creating ten hit area indexes. It is found that the snap of the clicker during archery shooting evokes N1–P2 components of long-latency evoked brain potentials. N1 amplitudes are significantly higher in hit area than that of miss areas for the 2nd and 4th indexes with 95% confidence intervals and 90% confidence intervals for the 1st and 3rd indexes with 90% confidence intervals. We conclude that the fall of the clicker in archery shooting elicits an N1 response with higher amplitude. Although evoked potential amplitudes were higher in successful shots, their latencies were not significantly different from the unsuccessful ones.
Seis especies nuevas de los géneros Drosophila e Hirtodrosophila (Diptera: Drosophilidae) en el Parque Nacional Podocarpus
Authors: Peñafiel-Vinueza Ana Danitza , Rafael Violeta
Published: February 2021

Seis especies nuevas de los géneros Drosophila e Hirtodrosophila provenientes de losbosques tropicales y nublados del Parque Nacional Podocarpus, Provincia de Loja y Zamora Chinchipe,Ecuador, son descritas e ilustradas. Estas especies son: Drosophila cajanuma sp. nov., D. kasha sp. nov.,D. podocarpus sp. nov., D. wachi sp. nov., Hirtodrosophila lojana sp. nov. e Hirtodrosophila villonacu sp.nov. Para las capturas de los drosophilideos se utilizaron trampas con cebo de banano y levadura.
Antiagregantes y anticoagulantes en el manejo de ectasia coronaria con flujo lento, una revisión de reportes de caso
Authors: Barreno Arcos Anthony
Published: February 2021

La ectasia coronaria es una dilatación profusa de todo el segmento arterial. Aún no se ha determinado la terapia más adecuada para el proceso trombogénico que acompaña a la ectasia coronaria, por lo que el objetivo de este estudio es establecer si las terapias: antitrombótica doble (TAPS+ACO), triple (TAPD+ACO) o solo con anticoagulante oral (ACO) son útiles para prevenir la recidiva de los síntomas. Se realizó una búsqueda de reportes de casos sobre ectasia coronaria y manejo con anticoagulantes y/o antiagregantes para la prevención de recidivas, publicados desde 1997 hasta mayo de 2020. Se incluyeron 11 reportes. Cinco pacientes recibieron terapia antitrombótica triple (TAPD+ACO), tres pacientes recibieron terapia antitrombótica doble (TAPS+ACO) y tres pacientes recibieron terapia solo con anticoagulante oral (ACO). Ninguno tuvo recurrencias en el periodo de seguimiento. Tanto la terapia solo con ACO, como la terapia antitrombótica doble (ACO + TAP) y triple (ACO + TAPD) mostraron beneficio al prevenir las recurrencias de síndrome coronario agudo (SCA) tras el seguimiento como mínimo de 3 meses. La terapia antitrombótica triple parece ser más eficaz que el uso de TAPD de manera aislada. El uso de nuevos anticoagulantes orales (NACO) podría tener mayor beneficio sobre el uso de los tradicionales. Sin embargo, se requieren más estudios al respecto.
Effect of Health Education with Flip Chart and Video on Knowledge about Early Detection of Cervical Cancer in Women of Reproductive Age in Nganjuk District, East Java
Authors:   School of Health Sciences Satria Bhakti Nganjuk, Nurrochmawati Ike , Retnoningrum Ambar Dwi ,   School of Health Sciences Satria Bhakti Nganjuk, Kusumaningrum Remita Yuli ,   School of Health Sciences Satria Bhakti Nganjuk
Published: February 2021

Background: Cervical cancer is the fourth most prevalent cancer in women. Pap smear and visual inspection acetic acid (VIA) are essential screening tests to early detect cervical cancer. However, the use of screening tests remained low among women of reproductive age in Nganjuk district, East Java. This study aimed to determine the effectiveness of health education using flip chart and video on knowledge about early detection of cervical cancer among women of reproductive age in Nganjuk district, East Java. Subjects and Method: A randomized control trial conducted in Rejoso, Nganjuk, East Java, from October to November 2019. A sample of 120 women of reproductive age was randomized into two groups: (1) Experiment group that received health education using a flip chart and video, and (2) Control group that received no intervention. The dependent variable was knowledge of early detection of cervical cancer. The independent variable was health education using a flip chart and video. The data were collected using questionnaire. The data were analyzed by independent t-test. Results: After the intervention, knowledge about early detection of cervical cancer in the experimental group (Mean= 80.40; SD= 10.54) was higher than the control group (Mean= 70.53; SD= 9.68), and it was statistically significant (p <0.001). Conclusion: Health education using a flip chart and video is effective in improving knowledge about early detection of cervical cancer among women of reproductive age. Keywords: early detection, cervical cancer, health education, women of reproductive age Correspondence: Ike Nurrochmawati. School of Health Sciences Satria Bhakti, Nganjuk. Jl. Panglima Sudirman VI, Nganjuk, East Java. Email: ike.nurrochma@gmail.com. Mobile: +6282141578108. DOI: https://doi.org/10.26911/the7thicph.02.36
Effect of Peer-Based Intervention on Unwanted Pregnancy Prevention Behavior in Adolescents: A Meta-Analysis
Authors:   Masters Program in Public Health, Universitas Sebelas Maret, Safitri Denanda Agnes , Rahardjo Setyo Sri ,   Faculty of Medicine, Universitas Sebelas Maret, Murti Bhisma ,   Masters Program in Public Health, Universitas Sebelas Maret
Published: February 2021

Background: Prevalence of adolescents’ unwanted pregnancy is relatively high in Asia (43%), Africa (45%), and both Latin America and Caribbean (74%). Unwanted pregnancy at an early age is correlated with social consequences as well as increased health risks for both mother and infants. Peer-based intervention is a program to promote sexual and reproductive health, including the prevention of unwanted pregnancy. This study aimed to assess the influence of peer-based intervention on unwanted pregnancy prevention behaviors in adolescents. Subject dan Method: Meta-analysis was conducted based on PRISMA guidelines. Articles with randomized controlled trial design published in 2000-2020 were included for meta-analysis. These articles were searched from PubMed, Science Direct, Research Gate, and Google Scholar databases. Keyword used “peer education” OR “peer led” OR “peer counseling” OR “peer approach” OR “peer teaching” OR “peer mentoring” AND “unwanted pregnancy” AND adolescent AND “randomized controlled trial”. Articles that met eligibility criteria were analyzed using Revman 5.4. Results: Ten articles met the criteria for a meta-analysis with sample size 15,439. This study showed that peer-based intervention (RR=1.12; 95% CI=0.95 to 1.32; p=0.160) improved unwanted pregnancy prevention behavior in adolescents, but it was statistically non-significant. Conclusion: Peer-based intervention improves unwanted pregnancy prevention behavior in adolescents, but it is statistically non-significant. Keywords: peer-based intervention, unwanted pregnancy, adolescents Correspondence: Denanda Agnes Safitri. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indosesia. Email: denandagnesafitri@gmail.com. DOI: https://doi.org/10.26911/the7thicph.02.43
Effectiveness of Cocoa (Theobroma Cacao L.) Seed Extract on the Growth of in Vitro Malassezia Furfur
Authors:   Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta, Montana Fajar Daniswara , Setyaningsih Yuni ,   Department of Parasitology, Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta, Zulfa Fajriati ,   Department of Parasitology, Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta
Published: February 2021

ABSTRACT Background: Pityriasis versicolor or Tinea versicolor is a skin disease caused by the Malassezia furfur which is often found in Indonesia. People can use anti-fungal drugs to treat this disease. However, long-term use of anti-fungal drugs is relatively more expensive and can have side effects for its users. Cocoa bean husk contains flavonoids, saponins, and alkaloids which have anti-fungal effects. This study aimed to determine the antifungal effectiveness of the cocoa bean husk extract on the growth of M. furfur. Subjects and Methods: This was an experimental study using cocoa bean husk extract with a concentration variance of 25%, 50%, 75%, 100%, with a positive control for ketoconazole 2% and a negative control using distilled water. The test was carried out by the well diffusion method using Sabouraud Dextrose Agar media. The inhibition of fungal growth was calculated by looking at the clear zone formed after 48 hours. Data were analyzed using Kruskal-Wallis and Post hoc Mann Whitney statistical tests. Results: The mean diameter of the inhibition zone at a concentration of 25%, 50%, 75% and 100% was 3.42 mm, 4.07 mm, 4.9 mm, and 7.3 mm, respectively, and it was statistically significant (p = 0.001). Conclusion: Cocoa bean husk extract has weak anti-fungal effectiveness at concentrations of 25%, 50%, and 75%, while at 100% it has moderate effectiveness. Keywords: antifungal, Pityriasis versicolor, cocoa bean shell, well diffusion, Malassezia furfur Correspondence: Yuni Setyaningsih. Department of Parasitology, Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta. DOI: https://doi.org/10.26911/the7thicph.05.01
Effectiveness of Soursop Leaf Extract to Decrease Malondialdehyde Level
Authors:   Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta, Caverina Sarah Lorenza , Yulianti Retno ,   Department of Anatomical Pathology, Faculty of Medicine Universitas Pembangunan Nasional “Veteran” Jakarta, Pramesyanti Andri ,   Department of Microbiology, Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta
Published: February 2021

ABSTRACT Background: In diabetes mellitus, hyperglycemia causes oxidative stress that enhances the production of free radicals. The presence of higher levels of malondialdehyde (MDA) indicates the rise of free radicals. On the basis of its role as an antioxidant that binds free radicals and reduces the level of malondialdehyde (MDA). Soursop leaf can act as an antidiabetic agent. This study aimed to examine the efficacy of soursop leaf extract (Annona muricata L.) to decrease the level of MDA level in alloxan-induced diabetic rats (Rattus norvegicus). Subjects and Method: This was an experiment study using pre- and pro-test with control group design. Total of 30 rats were selected for this study and divided into five groups of treatment i.e. group I was given distilled water and standard feed (Negative Control/KI), group II was given vitamin E 150 IU/kgBW/day (Positive Control/KII), group III was given soursop leaf extract 75 mg/kgBW/day (KIII), group IV was given soursop leaf extract 150 mg/kgBW/day (KIV), and group V was given soursop leaf extract 300 mg/kgBW/day (KV). Each group consisted of 5 rats and was given soursop leaf extract for 21 days after being induced by alloxan and high-fat diet. The data were analyzed using Mann-Whitney test. Results: There was a significant difference in KI group compared to KII, KIII, KIV, and KV groups. Soursop leaf extract of 150 mg/kgBW/day was the most effective dose to reduce MDA level in pancreatic rat. Conclusion: Soursop leaf extract of 150 mg/kgBW/day is the most effective dose on pancreatic MDA level reduction. Keywords: diabetes mellitus, soursop leaf extract, MDA, free radical Correspondence: Retno Yulianti. Department of Anatomical Pathology, Faculty of Medicine Universitas Pembangunan Nasional “Veteran” Jakarta. Jl. Fatmawati Hospital, Pondok Labu, South Jakarta. Email: retno.yulianti@upnvj.ac.id DOI: https://doi.org/10.26911/the7thicph.05.07
Relation Between Tiroid Status with Glycemic Control of Type 2 DM Patients at RSPAD Gatot Soebroto
Authors:   Faculty of Medicine, UPN Veteran, Jakarta, Yulianti Kartika , Wibudi Aris ,   Department of Internal Medicine, Faculty of Medicine, UPN Veteran, Jakarta, Citrawati Mila ,   Department of Faal, Faculty of Medicine, UPN Veteran, Jakarta
Published: February 2021

ABSTRACT Background: Diabetes Mellitus (DM) is a group of symptoms that arise due to increased blood sugar levels. Diabetes Mellitus type 2 has a higher risk of developing thyroid dysfunction. Thyroid dysfunction can affect various body metabolism and result in insulin resistance, significantly affecting glycemic control in DM patients. This study aimed to determine the relation between thyroid status as assessed by the level of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and glycemic control (HbA1c). Subjects and Method: A cross-sectional study. A sample of 38 DM patients was selected by purposive sampling. The dependent variable was glycemic control. The independent variables were TSH and FT4. Patients were classified into 4 quartiles (Q) based on their TSH and FT4 levels. Statistic test used was non parametric for category group of variables, which was Chi square test. Results: Mean of fasting blood glucose was 200,56 mg/dL (modus 137 mg/dL), mean of 2 hours post prandial blood glucose was 247 mg/dL (modus 305 mg/dL). Subjetcs with poor glycemic control dominated as much as 76%. Most subjects had TSH level at Q4 (36%), while most of the subjects had FT4 level at Q1 (34%). The results showed that 38 samples with poor glycemic control were 72% in the 4th quartile (Q4) (> 3.1750 mU / L) TSH, and 64.7% were in Q1 (≤ 11.8400) FT4. The analysis showed that there was a significant relation between TSH (p = 0.047) and FT4 (p = 0.041) with glycemic control in type 2 DM patients. Conclusion: FT4 and TSH levels relate to glycemic control in type 2 DM patients Keywords: TSH, FT4, HbA1c, Diabetes Mellitus Correspondence: Mila Citrawati. Department of Faal, Faculty of Medicine, UPN Veteran, Jakarta. Jl. RS Fatmawati, Pondok Labu, South Jakarta 12450, Telp. (021) 7656971. E-mail: milacitrawati@upnvj.ac.id. Mobile: 081282990515 DOI: https://doi.org/10.26911/the7thicph.05.12
Effect of Consuming Tomato (Solanu Mlycopersicum L) Juice and Red Spinach (Amaranthus Tricolor L) on Haemoglobin Levels of Reproductive Age Women in Payung Sekaki Public Health Center, Pekanbaru
Authors:   School of health sciences Al-Insyirah Pekanbaru, Pebriani Resda , Yanti Rifa ,   School of health sciences Al-Insyirah Pekanbaru
Published: February 2021

ABSTRACT Background: Anemia is a nutritional problem that affects millions of people in developing countries and remains a significant challenge for human health. This study aimed to determine the effect of giving a combination of tomato juice and red spinach on haemoglobin levels of reproductive age women in Payung Sekaki Community Health Center, Pekanbaru. Subjects and Method: This study was a experimental study with pretest and posttest one group design conducted in the working area of the Umbrella Sekaki Community Health Center Pekanbaru.A sample of 27 people was selected by purposive sampling. The dependent variable was an increase in hemoglobin levels in women of childbearing age. The independent variable was tomato and spinach juice. The data were collected by digital Hb set, a scale, a measuring cup. Results: Hemoglobin of women of reproductive age before being given intervention (Mean= 10.97; SD= 0.563) was higher after giving intervention (Mean = 11.68; SD 0.536) and statistically significant with (p > 0.05). Conclusion: There is an effect of giving a combination of tomato juice (Solanu Mlycopersicum L) and red spinach (Amaranthus Tricolor L) on Haemoglobin levels in WUS in the working area of in Payung Sekaki Community Health Center, Pekanbaru. Keywords: Combination of Tomato Juice and Spinach, Haemoglobin level. Correspondence: Resda Pebriani, School of health sciences Al-Insyirah Pekanbaru. Mustafa Sari No.5, Tengkerang Sel, Kec. Bukit Raya, Kota Pekanbaru, Riau. Email: pebrianiresda24@gmail.com. Mobile: 081231304336. DOI: https://doi.org/10.26911/the7thicph.05.14
The Effect of Brain Gym on Depression Levels in Elderly, Nogosari District, Boyolali, Central Java
Authors:   School of Health Polytechnic, Surakarta, Untari Rita
Published: February 2021

ABSTRACT Background: Elderly interpreted as a period of decline in physical and psychological functioning. This will have a negative effect on stressful situation and result in depression. This depressive state has an impact on the implementation of daily activities. One cognitive therapy method that can be applied to treat depressive disorders is to do a brain gym. Brain gym strives to activate the left and right brain optimally with simple movements and accompanied by music. This study aimed to determine the effect of the brain gym on depression levels in the elderly. Subjects and Method: This was an experimental one group pre-test and post-test design conducted at Tegalgiri Village, Nogosari, Boyolali, Central Java, from October to November, 2017. A total sample of 27 elderlies was selected by quota sampling. The dependent variable was depression. The independent variables (intervention) were brain gym with eight times and each session lasting 10-15 minutes. The data were collected by Geriatric Depression Scale (GDS) version 15. The depression score uses a numerical scale. The data were analyzed by pairwise comparison test. Result: Depression before intervention (Mean= 7.96) after the intervention (Mean= 6.45). The results of the comparison test obtained (r= 0.89; 95% CI= 1.23 to 1.74; t= 11,98, p< 0.001, df= 26). Conclusion: There are different levels of depression before and after the intervention. Brain gym has an influence on the level of depression in the elderly in Tegalgiri Village, Nogosari Boyolali. Encourage local health cadres to further activate integrated healthcare center for the elderly, one of the activities is gymnastics, including a brain gym. Keywords: Elderly, Brain Gym, Depression Correspondence: Rita Untari. School of Health Polytechnic, Surakarta, Jl. Letjen Soetoyo Mojosongo, Surakarta. Email: ritauntari@gmail.com. Mobile: 08164278544 DOI: https://doi.org/10.26911/the7thicph.05.19
Effectiveness of Sembung Tree Honey on Decreasing Cholesterol Level in Hypercolesterolemia
Authors:   Faculty of Nursing and Midwifery, Universitas Nahdatul Ulama, Surabaya, Purwanti Nunik , Putri Rahmadiar Aditya ,   Faculty of Nursing and Midwifery, Universitas Nahdatul Ulama, Surabaya, Nurjanah Siti ,   Faculty of Nursing and Midwifery, Universitas Nahdatul Ulama, Surabaya
Published: February 2021

ABSTRACT Background: Lifestyle changes, causing an increase in cholesterol. Honey has done a lot of research. The content of flavonoids can lower cholesterol. Many people consume Sembung tree honey, but not much research has been done, including its effectiveness in reducing cholesterol. This study aimed to analyze the effectiveness of sembung tree honey to reduce cholesterol levels in hypercholesterolemia. Subjects and Method: This was a quasi-experiment with pretest and posttest control group. A sample of 20 hypercholesterolemia sufferers in Kedensari Village was selected by purposive sampling. The dependent variable was hypercholesterolemia. The independent variable was sembung tree honey. The data was analyzed by Wilcoxon. Results: Cholesterol level after intervention (<240 mg / dL), lower before intervention (> 240 mg / dl), significant value p = 0.000. The mean coverage of cholesterol levels after the intervention (Mean = 185.50; SD = 6.05) was lower than that before the intervention (Mean = 247.20; SD = 6.96), it was statistically significant (p <0.001). Conclusion: Sembung tree honey is effective in reducing cholesterol levels. Keywords: Sembung tree honey, Hypercholesterolemia Correspondence: Nunik Purwanti. Faculty of Nursing and Midwifery, Universitas Nahdatul Ulama, Surabaya. Jl SMEA No 57 Surabaya. Email: noniek@unusa.ac.id. Mobile: 082141511655 DOI: https://doi.org/10.26911/the7thicph.05.22
Effectiveness of Material Using CT Scan and MRI After Use of Picture Archiving and Commucating System and Radiology Information System at Radiological Installation of Bukit Tinggi National Hospital, West Sumatra
Authors:   Postgraduate Administrative Studies, Faculty of Public Health, Universitas Indonesia, Bachtiar Adang ,   Faculty of Public Health, Universitas Indonesia
Published: February 2021

ABSTRACT Background: Efficiency while paying attention to service quality is the top priority of the hospital. The efficiency in radiology installations has also not gone unnoticed. The implementation of Picture Archiving and Commucating System (PACS) and Radiology Information System (RIS) is one of the efforts to control costs in radiology installations, especially in consumables’ efficiency (BHP). Bukittinggi National Stroke Hospital (RSSN), as one of the vertical hospitals located in the City of Bukittinggi, West Sumatra, has become a precursor to the implementation of PACS and RIS in this province. This study aimed to determine effect of material using ct scan and mri after use of picture archiving and communicating system and radiology information system at radiological installation of Bukittinggi national hospital, West Sumatra. Subjects and Method: This was a descriptive study conducted at Radiological Installation Of Bukittinggi National Hospital, West Sumatra from July 2020. The data were collected by observation and monthly report data. Results: The results of the analysis of the use of PACS and RIS had a significant impact on the cost efficiency of BHP CT scans and MRIs in the RSSN radiology installation reaching 97.9%. Conclusion: Transfer of CT scan and MRI results from film to DVD-R for internal RSSN patients with considerable efficiency. Keyword: PACS, RIS, cost control, BHP Correspondence: Widya. Postgraduate Administrative Studies, Faculty of Public Health, Universitas Indonesia. Pondok Cina, Kecamatan Beji, Kota Depok, Jawa Barat 12345. Email: mnwidya@gmail.com. Mobile: (021) 7864975 DOI: https://doi.org/10.26911/the7thicph.05.23