bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Senam Prolanis terhadap Perubahan Kadar Hemoglobin Sebelum dan Sesudah Senam di Klinik Cempaka Pulogebang Jakarta Timur
Authors: Nusantara Bangun Cholifa , Farhan Fanny Septiani
Published: May 2020

Latar belakang: hemoglobin memiliki fungsi yaitu mentranspor oksigen. Latihan aerobik menyebabkan jaringan kekurangan oksigen. Hipoksia jaringan akan merangsang ginjal mengeluarkan hormon eritropoetin. Eritropoetin merangsang pematangan eritrosit dalam sumsum tulang.  Sehingga akan menyebabkan peningkatan hemoglobin. senam Prolanis (Program Pengelolaan Penyakit Kronis) merupakan latihan jasmani aerobik yang merupakan salah satu program pemerintah. Penelitian ini ingin mengetahui pengaruh senam prolanis terhadap kadar hemoglobin sebelum dan sesudah senam. Metode: metode yang digunakan adalah kuasi eksperimen yang pembuktiannya diperoleh melalui perbandingan kondisi subjek sebelum perlakuan dengan sesudah diberi pelakuan dengan jumlah 16 responden. Dalam penelitian ini, jumlah sampel didapatkan dengan cara total sampling. Kadar Hemoglobin diukur dengan Point of Care Test (POCT). Hasil: pada penelitian ini hasil uji statistik telah didapatkan nilai p 0.276 yang berarti p>0.05 di mana didapatkan hasil yang tidak bemakna antara senam prolanis dengan perubahan kadar hemoglobin. Kesimpulan: didapatkan hasil bahwa tidak terdapat pengaruh antara senam prolanis dengan kadar hemoglobin. Karena dapat disebabkan beberapa faktor seperti ketidak efektifan senam, yang disebabkan waktu senam tidak mencapai nilai zona latihan pada penelitian ini.
Pengaruh Kepuasan Pelatihan, dan Keterlibatan Kerja Terhadap Niat Berpindah Karyawan (Studi Kasus : PT. XYZ Perusahaan Jasa Konstruksi Swasta)
Authors: Daiva Yonathan Fernando , Rahardjo Mukti
Published: May 2020

Human resources are an important role in the company's success in achieving its goals. without human resources, the company's goals will certainly not be achieved. employee turnover problems that will certainly be faced by every company. if the number of employee turnovers is high, of course this should be concern to the company so as not to hinder the achievement of company goals.The purpose of this study was to determine the effect of training satisfaction, work involvement and turnover intention at PT. XYZ Private Construction Company. This research was conducted to employees at PT. XYZ. The sampling method uses Purposive Sampling. Data collection was carried out by distributing questionnaires to 59 respondents. And this type of research is quantitative and uses analytical methods with the SmartPLS 3.0 program.The results showed that training satisfaction did not have a negative effect on turnover intention. Training satisfaction has a positive effect on work involvement. Work involvement has a negative influence on turnover intention. and there is a negative influence on job involvement mediating between training satisfaction and turnover intention.
Pengaruh Corporate Social Responsibility Terhadap Willingness To Purchase dengan Brand Image Sebagai Variabel Mediasi (Studi pada Kampung Dongeng Teh Sisri)
Authors: Helen Helen , Tunjungsari Hetty Karunia
Published: May 2020

The purpose of this study is to obtain an analysis of marketing initiatives through corporate social responsibility to increase willingness to purchase that gives effect through brand image. Especially for brands that are experiencing a brand image crisis, through this research, one of the steps that can be taken is through corporate social responsibility. The research sample uses a questionnaire method consisting of 230 respondents in two elementary schools that were held in the Kampung Dongeng Teh Sisri Village. Hypothesis testing uses multiple linear regression statistical methods. The results showed that corporate social responsibility had a positive effect on willingness to purchase both directly and through brand image, corporate social responsibility had a positive effect on brand image, then brand image also had a positive effect on willingness to purchase.
Pengaruh Pelatihan, Pengembangan dan Kepuasan Karyawan Terhadap Kinerja Karyawan Di PT XYZ
Authors: Laurensia Violeta
Published: May 2020

Human resource is one of the most important aspects of an organization. There are several indicators that can influence human resources which include but not limited to training, development, performance, and satisfaction. The goal from this research is to analyze the effect of training on employees’ performance, to analyze the effect of development on employees’ performance, to analyze the effect of employees’ satisfaction on their performance, and to analyze the effect of training and development on employees’ performance in PT XYZ. The sample size in this study is 70 people. The method used in this study is quantitative and the instrument used is questionnaire which is then analyzed using SPSS 22. The results are: (1) Training have a significant influence on employees’ performance (p-value < 0.05, 0.004), (2) Development do not have a significant influence on employees’ performance (p value > 0.05, 0.473), (3) Employees’ satisfaction have a significant influence on employees’ performance (p-value < 0.05, 0.00), (4) Training and development have a significant influence on employees’ performance (sig. value < 0.05 in the Anova test, 0.00).
Pengaruh Brand Awareness, Brand Image dan Customer Perceived Value Terhadap Purchase Intention
Authors: Hakim Luki Lukmanul , Keni Keni
Published: May 2020

This study aims to determine the effect of brand awareness, brand image, and customer perceived value on purchase intentions. The sampling technique used in this study is nonprobability sampling by purposive sampling using a quantitative approach by distributing questionnaires to 146 which valid respondents 142 respondents. Data analysis method used in this study is multiple regression analysis. For operational variables using the Likert scale method of validity used a computer measuring instrument that is SPSS 25.0. The results showed that the brand awareness variable have a significant and positif effect, brand image have a significant and positif effect, customer perceived value have a significant and positif effect on purchase intention. In this case the brand image is the most influences of purchase intention.
Jurnal Manajemen Bisnis dan Kewirausahaan
Authors: Magister Manajemen Admin
Published: May 2020

Jurnal Manajemen Bisnis dan Kewirausahaan Vol. 4 No. 3 - Edisi Mei 2020
Integrating Information and Communication Technologies Into Second and Foreign Language Teaching: Pedagogical Benefits and Considerations
Authors: Mai Nguyen Thanh
Published: May 2020

The article aims to review existing literature on the pedagogical benefits as well as considerations regarding the integration of Information and Communication Technologies (ICTs) into second and foreign language teaching. Greater collaboration and interaction, enhanced motivation and access to a huge repository of web-based materials are among the most popular advantages of ICTs. At the same time, ICT-integration into language teaching can be challenging due to the emergence of “multiliteracies” and the not-so-ICT-competent students in the language classroom. Besides, there are language teachers who fear that their professional identity could be disrupted as they try to adopt new technologies in their teaching. However, the review also points out that technologies do not automatically result in any remarkable pedagogical benefits without teachers’ selective use. It is the teachers who enlarge the potentials of ICTs in promoting meaningful interactions and real intercultural reflections beyond the conventional language classrooms.
Bonde universitário: ações de prevenção das infecções sexualmente transmissíveis: um relato de experiência
Authors: De Almeida Lilian Conceição Guimarães , Santos Jamile Mendes da Silva , Da Silva Yone Cardeal , Mascarenhas Rebeca Nascimento dos Santos , Dos Santos Maiara Oliveira , Do Nascimento Daine Ferreira Brazil , Brasil Bruna Prates Lopes
Published: May 2020

Objetivo: Relatar a experiência de graduandas de enfermagem em ações extensionistas de prevenção das Infecções Sexualmente Transmissíveis (IST). Relato de experiência: O projeto é composto por graduandas de enfermagem da Universidade Federal da Bahia. Para subsidiar as ações realizadas houve a formação teórico/prática, na qual eram realizadas discussões semanais fomentando uma maior aproximação da equipe executora com a temática. As ações extensionistas foram fundamentadas a partir de metodologias ativas e realizadas nos mais distintos espaços entre ruas, escolas e campi da universidade. Durante as abordagens foram disponibilizados materiais educativos sobre IST, insumos de prevenção como preservativos e gel lubrificante, além da realização de testagem para HIV. As capacitações que antecederam as atividades oportunizaram a ampliação dos conhecimentos e trocas de experiências significativas. Foi possível identificar que muitas pessoas adotam comportamentos de invulnerabilidade. Em contrapartida, também houve devolutivas positivas como expressões de interesse, curiosidade e relatos de vivências sobre o assunto.  As ações de prevenção extramuros implementadas foram percebidas como um importante mecanismo de enfrentamento das IST. Considerações finais: Falar sobre IST ainda é um tabu na sociedade. Atividades extensionistas, são fundamentais para o fortalecimento do vínculo entre academia e comunidade.
Uso de psicoestimulante por acadêmicos de medicina em instituição de ensino superior na Amazônia Ocidental
Authors: Zandoná Ingrid , Silva Anitha de Cassia Ribeiro da , Cavatti Mariana Moraes , Aguiar Jorge Victor Moreira , Andrade Kemilly Teixeira , Soares Camylla Felix , Tavares Mayara Gonçalves , Sousa Camila Maciel de
Published: May 2020

Objetivo: Avaliar o uso de psicoestimulantes entre acadêmicos de medicina em uma instituição de ensino superior na Amazônia Ocidental. Métodos: Trata-se de um estudo de caráter descritivo, exploratório, transversal e de abordagem quantitativa, realizado com 265 estudantes do primeiro ao sexto ano, maiores de 18 anos, por meio do preenchimento de questionários abrangendo questões relacionadas ao uso de psicoestimulantes. Os dados obtidos foram analisados com o auxílio do programa Microsoft Office Excel. Resultados: Segundo a amostra, 66,4% eram do sexo feminino e 33,5% do masculino. A idade média foi de 19 a 23 anos. No que tange ao uso de psicoativo, 65,2% afirmaram fazer uso de algum psicoestimulante, sendo que, 45,6% relataram regular ingestão e 19,6% informaram utilizar apenas no período avaliativo. Entre os principais motivos citados para o consumo foram: 57,7% devido a rotina e 24,1% pelo aumento da capacidade cognitiva. Mais de 57% consideram o uso de psicoestimulantes com melhora na rotina acadêmica, além de ajudar no aumento da capacidade cognitiva e compensar a privação do sono. Conclusão: Conclui-se que o uso de psicoativos se apresenta frequente na rotina dos acadêmicos de medicina, principalmente no período de provas.
Capturing the Flexibility of a Protein-Ligand Complex: Binding Free Energies from Different Enhanced Sampling Techniques
Authors: Wingbermühle Sebastian , Schäfer Lars V.
Published: May 2020

Enhanced sampling techniques are a promising approach to obtain reliable binding free energy profiles for flexible protein-ligand complexes from molecular dynamics (MD) simulations. To put four popular enhanced sampling techniques to a biologically relevant and challenging test, we studied the partial dissociation of an antigenic peptide from the Major Histocompatibility Complex I (MHC I) HLA-B*35:01 to systematically investigate the performance of Umbrella Sampling (US), Replica Exchange with Solute Tempering 2 (REST2), Bias Exchange Umbrella Sampling (BEUS, or replica-exchange umbrella sampling), and well-tempered Metadynamics (MTD). With regard to the speed of sampling and convergence, the peptide-MHC I complex (pMHC I) under study showcases intrinsic strengths and weaknesses of the four enhanced sampling techniques used. We found that BEUS can handle best the sampling challenges that arise from the coexistence of an enthalpically and an entropically stabilized free energy minimum in the pMHC I under study. These findings might be relevant also for other flexible biomolecular systems with competing enthalpically and entropically stabilized minima.
Gymnema Sylvestre A- Potential Inhibitor of COVID-19 Main Protease by MD Simulation Study
Authors: Subramani Senthil Kumar , Gupta Yash , Manish Manish , Prasad GBKS
Published: May 2020

Gymnema sylvestre (GS) is one of the herbal plant used since in ancient times. The present study aimed to assess bioactive compounds GS mainly gymnemic acids as potential inhibitors for COVID-19 against Mpro enzyme using a molecular docking study. The docking score observed between -53.4 to - 42.4 of all gymnemic acids and its derivatives. Molecular Dynamics (MD) simulation studies carried out at 100ns supported the stability of GS molecules within the binding pocket. RMSD score of less than 3.6. mainly, our results supported that these GS molecules bind to the domain I & II, and domain II-III linker of 3CLpro enzyme, suggesting its suitability as strong candidate for therapeutic against COVID-19.
Bacterial vaginosis in pregnancy: a current view on diagnosis and therapy (literature review)
Authors: Karapetyan Tamara E , Lomova Natalya A , Yusubova Valeria R , Gvenetadze Shota G
Published: May 2020

Bacterial vaginosis (BV) is the most prevalent lower genital tract disease in women of reproductive age (both pregnant and non-pregnant) and the most common cause of vaginal discharge and foul odor from the genital tract. To date, there is a lot of literature describing many different approaches to the diagnosis and treatment of BV during pregnancy. BV is common, and its precise prevalence varies widely depending on the patient population. Studies confirm that the prevalence of BV among pregnant women is the same as in the population of non-pregnant women, and ranges from 6 to 32%. The link between BV and a patient’s ethnicity, smoking, sexual behavior and douching was established. BV is more prevalent among African American women, smokers, sexually active women compared to virgins and those who use douching. Diagnosis of BV is based on clinical symptoms and the results of microbiological examination. Diagnostic criteria are the same for pregnant and non-pregnant women. If BV is confirmed, treat-ment is indicated. In most international guidelines on sexually transmitted infections, the use of either metronidazole 500 mg orally 2 times a day for 7 days, or clindamycin 300 mg orally 2 times a day for 7 days are recommended for the prevention of adverse obstetric outcomes. BV is considered as the risk factor for adverse obstetric outcomes, such as premature birth, premature rupture of membranes, spontaneous abortion, chorioamnionitis and postpartum infections, such as endometritis and infectious compli-cations in the area of the postoperative wound after cesarean section. Pregnant women with symptoms of BV are advised to be screened and treated to eliminate the symptoms. Treatment with oral or local antibiotics is acceptable to achieve recovery (cure) in pregnant women with a symptomatic course of BV and a low risk of adverse obstetric outcomes. Women without symptoms of BV and women without identified risk factors for preterm birth should not be routinely screened and treated for BV, while patients with an increased risk for premature birth may benefit from routine screening and treatment for BV.
Evaluation of implant-associated complications after mesh-implants setting in pelvic floor reconstruction
Authors: Yashchuk Alfiya G , Musin Ilnur I , Naftulovich Raisa A , Popova Elena M , Fatkullina Irina B , Absalyamova Dina F , Kamalova Kseniya A , Molokanova Anzhella R , Yashchuk Kseniya N
Published: May 2020

Relevance. According to world data, nowadays prevalence of pelvic floor dysfunction and pelvic organ prolapsed reaches 28%. Most specialists relate pregnancy and delivery to main factors of pelvic prolapse development. Due to lifespan growth frequency of pelvic organ prolapse development increases. According to FDA data annually in the world is made more than 100 000 surgeries with synthetic implants, herewith heavy complications occur in 3.4% and mild complications occur in 14.8% of all cases. About 58% of surgeries are made to women under the age of 60, 13% of patients needs re-intervention during next 5 years. It should be noted that in cases of relapse more than 30% of women need re-intervention. Aim. Evaluate implant-associated complications after mesh-implants setting. Materials and methods. We have made retrospective analysis of mesh-implant use in 458 patients with pelvic organ prolapse in 2018-2018 yy. on the base of Bashkir State Medical University clinic. In order to assess quality of life after mesh-implant setting, we used the following questionnaires: Incontinence Questionnaire Short Form (ICIQ-SF), and also Female Sexual Function Index (FSFI). In order to assess blood microcirculation indices after surgery, we used laser Doppler flowmetry evaluation from anterior vaginal wall. Results. All in all, there were revealed 13 (2.84%) implant-associated complications. In 4 patients ICIQ-SF points were from 3 to 15, which indicates manifestation of urgent urine incontinence signs. According to FSFI questionnaire, sexually active women have 31.5 points. Basic factor, which provokes pelvic floor muscles dysfunction is delivery. Besides, in group of women of reproductive age, pelvic floor muscles dysfunction (PFMD) is associated with the presence of concomitant gynecologic diseases (uterine myoma, endometriosis, ovarian tumors). In the group of women older than 45 years with the presence of somatic pathology - obesity and impaired blood circulation. According to LDF data from anterior vaginal wall women with PFMD have low blood circulation indices, herewith the lowest indices are registered in the group of women older than 45 years.
Management of menopausal women with a history of endometriosis
Authors: Ermakova Elena I. , Yureneva Svetlana V.
Published: May 2020

Aim. To formulate a position statement on the management of the menopause in women with a past history of endometriosis from the point of view of evidence-based medicine.
Materials and methods. Review of domestic and foreign literature, position of IMS and EMAS.
Results. The article describes the main modes snd ways of introducing MHT and their advantages. The expert position on the management of patients with a history of endometriosis during surgical and natural menopause is highlighted. Information on the prevalence and methods of treatment of postmenopausal endometriosis is given.
Follicular fluid and assisted reproductive technology programs outcomes (literature review)
Authors: Burduli Anna G. , Kitsilovskaya Natalia A. , Sukhova Yuliya V. , Vedikhina Irina A. , Ivanets Tatiana Y. , Chagovets Vitaliy V. , Starodubtseva Nataliia L. , Frankevich Vladimir E.
Published: May 2020

The review presents data on metabolites in the follicular fluid (FF) from the perspective of reproductive medicine and their use in order to predict outcomes of assisted reproductive technology (ART) programs. It considers various components of this biological medium (hormones, lipids, melatonin, etc.) with an assessment of their predictive value in prognosis of the effectiveness of in vitro fertilization (IVF) programs. The data on experimental directions in this field and the prospects for their use in clinical practice are presented. The article emphasizes that the growing clinical need and the unsolved problem of increasing the effectiveness of ART programs determine the need for further studies of the FF composition.
Materials and methods. The review includes data related to this topic from foreign and Russian articles found in PubMed which were published in recent years.
Results. Given the established fact of a direct effect of FF composition on growth and maturation of oocytes, and further, on the fertilization process, various FF metabolites are actively investigated as non-invasive markers of quality of oocytes/embryos. The article provides data on the experimental directions in this field and the prospects for their use in clinical practice. However, clinical studies of a relation between various FF metabolites levels and outcomes of IVF programs are contradictory.
Conclusion. Owing large economic cost for treatment of infertility with IVF, there is need for expansion and intensification of studies to identify and use reliable predictors in prognosis of ART programs outcomes.
The use of progesterone during pregnancy in women with epilepsy as an alternative to the correction of doses of anticonvulsants
Authors: Tsallagova Elena V. , Generalov Vasily O. , Sadykov Timur R.
Published: May 2020

Pregnancy is the most dangerous period in terms of interruption of even persistent and long-term remission. At the same time increasing the dose of anticonvulsant increases the risk of teratogenic effects.

Aim. to assess the possibility of using progesterone to prevent relapse of epileptic seizures during pregnancy.

Materials and methods. 38 pregnant patients with epilepsy with clinical remission before pregnancy, with relapse of epileptic seizures in I trimester of pregnancy, age 31.81.4 years. Dydrogesterone in a dose of 10 to 60 mg/day was prescribed after the relapse of remission. Anticonvulsant dosage was not changed. The blood progesterone concentration and EEG control was carried out.

Results. During pregnancy, the level of progesterone in the blood gradually increased from 77.8 nmol/l at 78 weeks of pregnancy to 521.1 nmol/l at 3637 weeks of pregnancy, without exceeding the limits. EEG results did not deteriorate. None of the patients had seizures during pregnancy.

Conclusion. Progesterone therapy is an adequate and safe alternative to increasing the dose of anticonvulsants in case of recurrent seizures during pregnancy.
Pregravid preparation and pregnancy management of women with endometriosis in the in vitro fertilization program: a clinical case
Authors: Tetelyutina Faina K. , Shestakova Olga V. , Dolgova Olga N. , Shirobokova Liudmila M.
Published: May 2020

The presented clinical case of a patient with infertility and a combination of various forms of endometriosis was the basis for discussing the optimal choice of tactics for managing these patients.
Androstenedione as a potential predictor of ovarian response in assisted reproductive technology programs
Authors: Burduli Anna G. , Kitsilovskaya Natalia A. , Sukhova Yuliya V. , Vedikhina Irina A. , Ivanets Tatiana Yu. , Chagovets Vitaliy V. , Starodubtseva Nataliia L. , Frankevich Vladimir E.
Published: May 2020

Aim. To assess the possibility of using androstenedione levels in blood serum and follicular fluid to predict ovarian response in assisted reproductive technology programs and to conduct a comparative analysis of the results obtained by 2 methods chemiluminescent immunoassay (CLIA) and high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS).
Materials and methods. A prospective study included 55 couples who received in vitro fertilization/intracytoplasmic sperm injection and embryo transfer program therapy. The patients were divided into 3 groups depending on the ovarian response to stimulation: 1st (13 oocytes, n=4), 2nd (49 oocytes, n=27), 3rd (over 10 oocytes, n=24). Androstenedione levels were measured in blood serum obtained on the day of transvaginal ovarian puncture and in follicular fluid samples with CLIA and HPLC-MS/ MS methods at the laboratories of Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology.
Results. On the day of transvaginal ovarian puncture, the serum androstenedione levels, which were measured by HPLC-MS/MS, were increasing with an increase of the number of oocytes obtained. The CLIA method revealed a difference in the androstenedione levels between the groups with the number of oocytes obtained of less than 3 and more than 10. Moreover, the androstenedione levels measured by CLIA were significantly different between the patient groups (p0.05).
Comparison of serum androstenedione levels measured by CLIA and HPLC-MS/MS, showed high correlations between the values [=0.73 (p0.001)], which makes it possible to use both methods equally, given the existing equipment of the clinical base.
Conclusion. Prediction of ovarian response to stimulation is an important step in assisted reproductive technology programs. Measuring androstenedione concentration in blood serum on the day of transvaginal ovarian puncture with highly specific methods (CLIA and HPLC-MS/MS) can be used to predict the degree of ovarian response along with the traditional assessment of the ovarian reserve based on determining anti-Mullerian hormone levels in the early follicular phase of the menstrual cycle.
The occurrence of human papillomavirus types in the formation of neoplastic transformation of the epithelium of the cervix in “lesser abnormalies”
Authors: Sycheva Elena G. , Nazarova Niso M. , Burmenskaya Olga V. , Prilepskaya Vera N. , Trofimov Dmitry Yu.
Published: May 2020

Aim. To assess the frequency of human papillomavirus (HPV) occurrence according to the IARC classification in patients with lesser abnormalie of cervical epithelial lesions and analyze their role in the formation of SIL.
Materials and methods. The study included 129 HPV-positive women aged 1845 years (average age 34 to 11 years) with cytological conclusion NILM, ASCUS or LSIL. Patients are divided into 3 groups depending on the results of the cytological smear: 1 group (NILM/HPV) 66 (51.2%), 2 group (ASCUS/HPV) 28 (21.7%), 3 group (LSIL/HPV) 35 (27.1%). During dynamic observation for 24 months. A comprehensive clinical-laboratory examination was carried out, including HPV-typing, cytological examination, extended colposcopy every 6 months, sighting biopsy of the cervix (according to the indications).
Results. According to the results of the pathomorphological study, squamous intraepithelial lesions neoplasia (cervical intraepithelial neoplasia CIN+) was verified in 59 (71.9%) of the results of the study: LSIL (CIN I) 53 (64.6%), HSIL (CIN IIIII) 6 (4.6%). The morphological diagnosis of LSIL (CIN I) was established in 1 group (NILM/HPV+) in 20 (55.6%), 2 groups (ASCUS/HPV+) 9 (32%), 3 group (LSIL/HPV) 24 (68.6%); HSIL (CIN IIIII) in group 1 2 (5.6%), in 2 group 3 (10.7%) and in the 3 group 1 (2.9%).
Conclusions. In patients with lesser abnormalies of cervical lesions in the formation of CIN+ participated HPV group 1 in 79.1%, groups 2A in 5.5%, groups 2B in 15.4% of cases. The HPV high carcinogenic risk (group 1) was involved in the formation of HSIL (CIN IIIII). The neoplastic transformation of the cervical epithelium of the studied patients was caused by the persistence of HPV 16, 58, 39, 18, 51, 68, 56, 82, 35, 52, 53, 35 types.
Role of immunocorrection therapy in comprehensive treatment of patients with inflammatory diseases of female genital organs
Authors: Shchukina Natalia A. , Vinitskiy Aleksandr A.
Published: May 2020

Aim. Analysis of gynecological diseases structure in which immunocorrection with Polyoxidonium was prescribed, determination of a preferential drug form (suppositories 12 mg/lyophilisate 6 mg), assessment of its clinical effectiveness.
Outcomes and methods. Observational program of clinical efficacy of Polyoxidonium (12 mg suppositories or 6 mg lyophilisate) used along with standard treatment in 8975 women with inflammatory diseases of female genital tract in 20 regions of the Russian Federation in accordance with international standards of good epidemiological practice (GEP).
Results. The overall assessment of Polyoxidonium used along with the standard treatment in patients with inflammatory diseases of female genitals was 4.170.75 points (4 marked improvement; 5 full recovery). The drug was significantly more effective in vaginitis (4.360.68 points) and cervicitis (4.400.74 points) compared with standard therapy. In PID the most effective drug form was lyophilisate.
Conclusion. The drug is well tolerated, practically free of side effects and addiction, convenient in use and is compatible with any treatment regimen. In the treatment of lower genital tract inflammatory diseases, it is optimal to use the drug in the form of suppositories while in the treatment of PID in the form of a lyophilisate.
Analysis of efficiency of application of media with hyaluronic acid in cryoprotocols
Authors: Protopopova Natalia V. , Druzhinina Elena B. , Krylova Kseniia V. , Mylnikova Iuliia V. , Dvoryanov Jan A. , Labygina Albina V. , Kovalenko Inna I.
Published: May 2020

According to the World Health Organization, about 2 million new couples experience infertility annually, and their number is growing. An effective way to overcome infertility is assisted reproductive technology (ART). Cryopreservation will rationally solve the issue of preservation and further use of embryos: to delay pregnancy for some time considering womans desire and to prevent ovarian hyperstimulation syndrome. Embryo freezing allows to reduce the rate of repeated ovarian stimulation and perform preimplantation genetic diagnosis. Over the past decades, various cryotransfer options have been proposed to increase ART treatment efficacy, including the use of a culture medium with a high concentration of hyaluronic acid, but there are conflicting data on the use of such a medium in ART programs.

Aim. Evaluation of thawed embryo transfers efficacy using the hyaluronic acid-containing culture medium. To achieve the goal, the following tasks were set: to evaluate clinical and medical history data of patients with tubal infertility in cryoprotocols, to analyze the previous cycle of in vitro fertilization and embryological stage, to evaluate the effectiveness of the culture medium with a high content of hyaluronic acid.

Materials and methods. A detailed description of the patient sample, inclusion and exclusion criteria, embryological stage, embryo grading, devitrified embryo transfer technique. The article includes 3 tables which present the groups general clinical characteristics, the embryological stage, the rate of pregnancy, depending on the cultivation day.

Results. The authors established that in patients with a history of pelvic surgery and sexually transmitted infections, it is advisable to use the culture medium with a high content of hyaluronic acid to transfer the thawed embryo. It was shown that pregnancy rate is 1.5 times higher when transferring devitrified embryos on the 5th day of development with the use of hyaluronic acid-containing culture medium.

The conclusion about the pregnancy rate in obese patients is not indisputable, which requires further study. The authors also provide practical recommendations on the use of the culture medium with hyaluronic acid in cryoprotocols.

Conclusion. The study allows to optimize the devitrified embryo transfer in patients with tubal infertility using a culture medium with a high content of hyaluronan. This work has undoubted scientific and practical significance.
Case study: urethral diverticulum with calcifications in a premenopausal woman
Authors: Chuprinin Vladimir D. , Gorpenko Anton A. , Zaitsev Nikon V. , Asaturova Aleksandra V. , Buralkina Natalia A.
Published: May 2020

Female urethral diverticulum is a fairly rare pathology, the frequency of which ranges from 0.02 to 6.00% of women worldwide. The stones inside urethra diverticulum even more rare. The most common reasons of urethral diverticula are frequent bladder catheterizations, labour trauma, infections. Clinically is may present with the dysuria, dyspareunia, dribble, urinary incontinence, vaginal discomfort. Voiding cystourethrography and cystourethroscopy are the most accurate methods of diagnosis for urethral diverticula. The presented article describes the clinical case in women with urethral diverticulum who complained on the vaginal discomfort, dyspareunia and presentation of the brown stones in vagina and underwent surgical excision of diverticulum with urethral reconstruction.
New coronoviral infection and other respiratory-viral diseases in pregnant women: clinical lecture
Authors: Sinchikhin Sergey P. , Stepanyan Lusine V. , Mamiev Oleg B.
Published: May 2020

Relevance. On February 11, 2020, the World Health Organization (WHO) gave the official name for the disease caused by the SARS-CoV-2 coronavirus COVID-19 (Coronavirus disease 2019), and on March 11, 2020, the Director-General (WHO) stated that the world the community is facing a new pandemic. The rapid spread of this disease requires new knowledge on its diagnosis and treatment. At the same time, it must be remembered that 3040% of the entire world population is sick with other acute respiratory viral diseases every year. In our country, annually from 27 to 41 million cases of acute respiratory viral infection (ARVI), acute respiratory disease (ARI) and flu are recorded. Based on the foregoing, the authors set a goal on the basis of modern data to form the theoretical basis for obstetrician-gynecologists for practical work with pregnant patients with new coronavirus infection and respiratory viral diseases.

Materials and methods. The information material includes data from foreign and domestic scientific articles available in Pubmed and Internet resources on this topic, published over the past 5 years.

Results. A systematic analysis of the data contained in the modern literature on various infectious and inflammatory diseases of the respiratory system and COVID-19 has been carried out. Historical information on pandemics associated with respiratory diseases is presented. Clinical features of the course of acute respiratory viral diseases, flu and coronavirus infection, as well as various types of pneumonia, were noted. Attention is drawn to the importance of carrying out preventive measures to prevent the spread of infections. Introduced obstetric management of pregnant women with a new coronavirus disease. Part of the information is presented in the form of tables and figures summarizing the analyzed material, which makes the information presented especially memorable.

Conclusion. It is hoped that the prepared lecture will not only enhance information and educational knowledge, but will also be useful for the work of an obstetrician-gynecologist, including in the epidemiological period that is unfavorable for respiratory viral diseases.
Teknolojik Yeniliklerin Bankacılık Hizmetlerine Etkisi: Türk Bankaları Üzerinde Bir Değerlendirme
Authors: TEPE KÜÇÜKOĞLU Mübeyyen , AKCA Meltem
Published: May 2020

Teknolojinin getirdiği yenilikler çeşitli sektörlerle birlikte bankacılık sektörünü de etkilemiştir. Sektörde rekabetin artmasıyla birlikte teknolojik yenilikler bankaların stratejilerinin önemli bir parçası olmuştur. Mevcut bankacılık işlemlerinin kolaylaşmasını sağlayan çeşitli uygulamalar müşteri açısından işlem kolaylığı ve zaman tasarrufunun yanı sıra, bankalar açısından mevcut şube ve personele olan ihtiyacın azalması gibi birtakım avantajları da beraberinde getirmektedir. Bu noktadan hareketle, teknolojik yeniliklerin ve bu yenilikler sonucu ortaya çıkan elektronik dağıtım kanallarının bankacılık hizmetlerine olan etkilerini incelemeyi amaçlayan bu çalışma ortaya çıkmıştır. Bankacılık sektöründe çalışan 246 personelin katılımıyla gerçekleştirilen anket çalışmasının bulguları değerlendirilmiştir.
The Relationship between the 21st Century Maritime Silk Road Initiative and Chinese Naval Strategy
Authors: TÜYSÜZOĞLU Göktürk , ÖZGEN Cenk
Published: May 2020

China, who has put its economic might right at the center of its global influence, wants to consolidate its efforts in this regard with the 21st Century Maritime Silk Road Initiative. As this initiative shall increase the strength of China within the context, specific to South China Sea-Indian Ocean, it has also potential to make the states in the region economically dependent to Beijing. For an endeavor like this to succeed, China will need to prioritize the security of the 21st Century Maritime Silk Road. Right at this point, the new Chinese Naval Strategy that is predicated upon the expansion towards the high seas comes to the forefront. The investments and changing naval strategy that commence in parallel to the base and port facilities that would be obtained from various countries within the 21st Century Maritime Silk Road Initiative prove that China’s trade oriented leaps and its military and political planning have a striking parallelism. This study, based on literature review, aims to analyze the relationship between the 21st Century Maritime Silk Road Initiative and Chinese Naval Strategy.
Otel Çalışanlarının Kurumsal Sosyal Sorumluluk Algısının İşveren Çekiciliği ve Duygusal Bağlılık Üzerine Etkisi: Kurumsal İtibarın Aracılık Rolü
Authors: BOĞAN Erhan
Published: May 2020

Bu çalışmanın amacı, otel çalışanlarının kurumsal sosyal sorumluluk (KSS) algısının duygusal bağlılık ve işveren çekiciliği üzerine etkisinde algılanan kurumsal itibarın aracılık rolünü incelemektir. Veriler, Türkiye’nin en önemli destinasyonlarından biri olan İstanbul bölgesinde sosyal sorumluluk faaliyetlerinde bulunan beş yıldızlı üç otel işletmesinde çalışan 280 kişiden toplanmıştır. Araştırma modeli yapısal eşitlik modellemesinin kısmi en küçük kareler yöntemi kullanılarak test edilmiştir. Yapılan analizler sonucunda, çalışanların KSS algısının kurumsal itibar üzerine pozitif bir etki oluşturduğu belirlenmiştir. Çalışanların kurumsal itibar algısının hem duygusal bağlılık hem de işveren çekiciliği üzerine pozitif bir etki oluşturduğu belirlenmiştir. Son olarak kurumsal itibar algısı, algılanan KSS işveren çekiciliğinde kısmi aracılık rolüne sahipken; algılanan KSS ve duygusal bağlılık ilişkisinde aracılık rolü desteklenmemiştir. Elde edilen bulgular doğrultusunda uygulamacılara yönelik öneriler geliştirilmiştir.
KARAKTERISTIK TALI AGEL BERKITOSAN SEBAGAI BAHAN ALAT PENANGKAPAN IKAN
Authors: Komarudin Didin , Baskoro Mulyono , Diniah Diniah , Murdiyanto Bambang , Suptijah Pipih
Published: May 2020

Agel ropes have lower mechanical properties (breaking strength and elongation) than synthetic fiber ropes. Chitosan coating is expected to improve the mechanical properties of agel ropes. The aims of this study are to investigate the effect of immersion in chitosan on the physical and mechanical properties of agel ropes, and to examine the breaking strength and elongation of coated agel ropes after being soaked in both freshwater and seawater. This experimental study was conducted at the Laboratory of Fishing Gear Technology, Department of Fisheries Resources Utilization IPB University, and Laboratory of Forest Product Engineering, Department of Forest Products IPB University. The experiment involved 3 mm in diameter of two agel ropes incorporating control rope and agel rope soaked in 1% chitosan for 24 hours. The control rope was light brown, stiff, and rough, while the treated rope was darker, less stiff, and smoother. The breaking strength of control and treated rope was significantly different (P<0.05), which in respect constitute 15.06 kgf and 24.54 kgf. The elongation of both ropes were also significantly different (P<0.05), making 10,56% for control and 18,04% for treated rope. Breaking strength of the agel rope decreased by 50% after being immersed for 28 days.

Keywords: agel rope, chitosan, breaking strength, elongation
KEANEKARAGAMAN JENIS IKAN HASIL TANGKAPAN SAMPINGAN (BYCATCH) PERIKANAN RAJUNGAN DI TELUK LASONGKO DAN KENDARI SULAWESI TENGGARA
Authors: Hamid Abdul , Kamri Syamsul
Published: May 2020

Information regarding the diversity of bycatch from blue swimming crab fishing operations is important in ecosystem-based management and assessment for Marine Stewardship Council (MSC) certification of crab fisheries in Southeast Sulawesi and Indonesia. However, data limitation becomes major challenges. This study aims to specify the types of bycatch caught from blue swimming crab fishing in Lasongko and Kendari Bay Southeast Sulawesi. This research was conducted in March to September 2019. Data was collected from trap and bottom gillnet fishing by using a purposive sampling method on a monthly basis. Bycatch was categorized into two groups, namely economically valuable and discarded, according to the local fishers’ perception. Information was presented both spatially and temporally. The results show that bycatch consists of 66 species including 41 economically valuable and 26 discarded species. Indices of diversity, evenness and dominance of fish were also discussed to describe the ecological conditions. Accordingly, this bycatch composition is able to support the management and assessment of MSC certification of crab fisheries in Southeast Sulawesi.

Keywords: bycatch, fish diversity, blue swimming crab fisheries, Southeast Sulawesi.
Por que não ponderar ou subsumir?
Authors: Dytz Marin Jeferson , Ramos Neto Nelson Gularte
Published: May 2020

O objetivo do presente artigo é analisar a compatibilidade da subsunção e da ponderação, utilizadas para aplicação das regras e princípios, com as necessidades do Constitucionalismo Contemporâneo. Investigar-se-á se propostas de técnicas decisórias, amplamente adotadas pela literatura jurídica pátria, são adequadas ao que se espera de um novo paradigma jurídico denominado pós-positivismo, (re)pensado a partir do Estado Democrático de Direito, antecipando-se que a hipótese aponta no sentido de uma resposta negativa, tendo em vista a identidade que se estabelece entre as técnicas supracitadas e o paradigma positivista.
Effects of Lacosamide in Rats with Lipopolysaccharide Induced Hepatic Pathology
Authors: ÖZMEN Özlem , İPEK Volkan
Published: May 2020

Bacterial lipopolysaccharides (LPS) generally increase the pathogenicity of the agent. This study aimed to examine the hepatic pathology and possible prophylactic effects of lacosamide (LCM) in a LPS-induced sepsis rat model. Overall, 24 1-year-old female Wistar Albino rats were divided into three groups: Group I (control), Group II (LPS group: 5 mg/kg LPS intraperitoneally, single dose), and Group III (LCM group: 40 mg/kg LCM intraperitoneally once daily for 3 days plus 5 mg/kg LPS 30 min after the last LCM treatment). Animals were euthanized 6 hours after LPS administration. Blood and liver samples collected during necropsy were analyzed biochemically, pathologically, and immunohistochemically. LPS caused a significant increase in serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, direct bilirubin, indirect bilirubin, and alkaline phosphatase levels. Histopathological analysis revealed numerous neutrophil leucocyte infiltrations, slight hemorrhages in the liver, and degenerative or necrotic changes in hepatocytes. Increased expressions of malondialdehyde, C-reactive protein, heat shock protein-70, interleukin-1β, and tumor necrosis factor-α were observed in the LPS administered group. LCM ameliorated the biochemical, histopathological, and immunohistochemical findings. The present study results revealed that LCM ameliorated the LPS-induced liver damage in the rat models as evidenced by the biochemical and pathological findings.
VALUABLE DONORS OF DIPLOID GAMETES FOR TRIPLOID APPLE TREE VARIETIES CREATION
Authors: Седов Е. N. , Yanchuk T. V. , Korneeva S. А.
Published: May 2020

As a result of the long-term research, several of the most promising donors of diploid gametes were selected among apple cultivars and elite seedlings. Among the cultivars, these are Antonovka Ploskaya (2-4-4-4x), Melba tetraploid (4x), Papirovka tetraploid (2-4-4-4x) and Wealthy tetraploid (2-4-4-4x), while among the seedlings these are 13-6-106 (Suvorovetz seedling) (4x) and 30-47-88 (Liberty × 13-6-106) (4x + Vf). New apple cultivars of summer maturation Avgusta, Dariona, Maslovskoye and Osipovskoye have already been released with the participation of Papirovka tetraploid (2-4-4-4x) and included in the State register of breeding achievements admitted for use. New zoned cultivars Alerksandr Boyko, Bezhin Lug, Vavilovskoye and Ministr Kisilev have been released with the participation of Wealthy tetraploid (2-4-4-4x). Triploid apple cultivars Orlovsky Partizan, Patriot and Mars have been released with the participation of 13-6-106 (Suvorovetz seedling) as a donor of diploid gametes. Orlovsky Partizan and Patriot are zoned, while Mars is passing the state testing. 30-47-88 (Liberty × 13-6-106) (4x + Vf) is of particular value as both a donor of diploid gametes and a donor of scab immunity (Vf). Priorities in apple breeding at VNIISPK are the development of the immune to scab (24 scab immune cultivars are zoned) and columnar cultivars (5 cultivars are zoned: Vostorg, Girlianda, Poezia, Priokskoye and Orlovskaya Yesenia). We have already developed triploid apple cultivars that have immunity to scab. It is tempting to create triploid cultivars that are immune to scab and columnar ("three in one"). The creation of such cultivars will allow to provide more regular fruiting in the orchard and fruits of high commodity and consumer qualities (due to triploidy), improve the environmental situation in the orchard and its surroundings (due to immunity to scab), and significantly increase the yield (due to column-shaped varieties). We hope that in the coming years such cultivars will be created, since there are already selected apple seedlings with such a combination of valuable features.
IDENTIFICATION OF BLACKCURRANT VARIETIES (RIBES NIGRUM L.) BASED ON MICROSATELLITE LOCUS POLYMORPHISM
Authors: Dolzhikova М. А. , Pikunova А. V. , Tolpekina А. А. , Knyazev S. D. , Bakhotskaya А. Yu.
Published: May 2020

Currently, the State Register of breeding achievements approved for use includes 198 blackcurrant varieties. The urgent task is their identification, given the large number of varieties. This paper presents the genotypes of 28 blackcurrant varieties at 11 microsatellite locus obtained by using the most advanced detection method is fragment analysis by capillary electrophoresis. For all varieties unique profiles are obtained. We propose to use, as controls, varieties of different originators and various origins Ben Conan (originator SCRI, UK), Iskushenie (originator VNIISPK, RF), Charodey (Kokinsky base, Russia) that are quite popular in production. The research results can be used to identify the variety samples involved in the analysis.