bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and synthesis of Diphenyl-1H-imidazole analogs towards SARS CoV-2 3CLpro inhibition for the treatment of COVID-19
Authors: Kanhed Ashish M. , Vora Amisha , Thakkar Ami , Rudramurthy Gudepalya Renukaiah , Shandil Radha Krishan , Yogi Maddipatla , Harisha Rajappa , Singh Mayas , Narayanan Shridhar
Published: February 2023

COVID-19 caused by novel corona virus (SARS-CoV-2) is the major pandemic of the decade claiming millions of lives causing severe disruptions to society. Despite rapid development of COVID-19 vaccines, condition is still not under control and newer antiviral drugs are required. In the present work, we describe the design and synthesis of Diphenyl-1H-imidazole derivatives as a potential lead series for SARS-CoV-2 3CLpro enzyme inhibition. The synthesized molecules were screened for SARS-CoV-2 3CLpro enzyme inhibition at 20µM concentration. All the synthesized compounds (6-14) showed inhibition in the range of 88 to 99%. They were further tested for anti-SARS-CoV-2 activity against ancestral Wuhan and the Delta variants in virus infected cells. The compounds 4-(4-hlorophenyl)-2-(3,4-dimethoxyphenyl)-1H-imidazole (9), 4-(2,4-dichlorophenyl)-2-(3,4-dimethoxyphenyl)-1H-imidazole (10), 4-(4-(2,4-dichlorophenyl)-1H-imidazol-2-yl)benzene-1,2-diol (14) showed promising activity against both Wuhan (IC50: 7.7 µM, 12.6 µM and 11.8 µM, respectively) and Delta (IC50: 7.4 µM, 13.8 µM and 12.1 µM, respectively) variant of COVID-19. Our results demonstrate efficacy of diphenyl-1H-imidazole derivatives as promising ligands for further development and optimization against COVID-19.
The tourist patterns in European countries. Application of a protocol for dynamic clustering of geographic spaces
Authors: Landaluce-Calvo M Isabel
Published: February 2023

The methodological proposal presented in this paper enables a comprehensive multivariate exploratory analysis of time series taken in different geographical contexts. More specifically, it is a four-stage protocol for the identification of different dynamic patterns and the subsequent formation of geographic clusters. The clustering strategy compares the shapes of the trajectories using a natural, unsupervised approach based on learning from data. The exploratory techniques used in this method, which are readily applicable in any area of study, begin by reducing the dimensionality of a three-way data array. The potential of the strategy design is illustrated through a study of tourism dynamics in 27 European countries over the period 2007-2019. The profiles found for the trend and seasonal components reveal five distinct tourism patterns with some singularities. The choice of this sector for empirical research is not accidental. Tourism is connected to areas related to both economic and social activity. That is why their correct measurement and analysis are so interesting and necessary.
Identification of hsa-miR-4770 as characteristic microRNA of gallbladder carcinoma and exploration on the ceRNA regulation mechanism via integrated bioinformatics analysis
Authors: Shao Hanrui , Zhu Jiahai , Zhu Ya , Liu Lixin , Zhao Songling , Kang Qiang , Liu Yunxia , Zou Hao
Published: February 2023

Background and Aims:
Gallbladder carcinoma (GBC) is a highly malignant tumor with a poor overall prognosis. This study aimed to identify the characteristic microRNAs (miRNAs) of GBC and the competing endogenous RNA (ceRNA) regulatory mechanisms.
Methods
GBC-related differentially expressed miRNAs (DE-miRNAs) were authenticated by differential expression analysis and weighted gene co-expression network analysis (WGCNA). The characteristic miRNA was extracted by least absolute shrinkage and selection operator (LASSO) and Support vector machine-recursive feature elimination (SVM-RFE). Targeting genes (mRNAs), upstream circularRNAs (circRNAs), and long noncoding RNAs (lncRNAs) prediction for the characteristic miRNAs was conducted by using the Starbase database. The lncRNA(circRNA)-miRNA-mRNA network was created by Cytoscape software. Gene Ontology (GO) and KEGG enrichment analysis was implemented by clusterProfiler R package. The varElect was applied to analyse the target genes, and search for functions and interactions by GeneMANIA. The expression of characteristic miRNA in clinical samples was verified by quantitative real-time polymerase chain reaction (RT-qPCR).
Results
A total of 131 GBC-related DE-miRNAs were obtained. The hsa-miR-4770 was defined as characteristic miRNA for GBC. The ceRNA network containing 211 mRNAs, 1 miRNA, 2 lncRNAs, and 48 circRNAs was created. The downstream genes were mainly involved in actin filament organization, cell-substrate adhesion, cell-matrix adhesion, reactive oxygen species metabolic process, glutamine metabolic process and extracellular matrix (ECM)-receptor interaction pathway. 10 key genes in the network, namely BRCA1, CHEK2, RB1, CASP8, PTGS2, CD44, KRT19, CDK1, PVT1, and MXRA5 were found to be most correlated with disease. Multiple genes involved in cell cycle-related processes, p53 related pathway, and extrinsic apoptotic signaling pathway. RT-qPCR result demonstrated that the expression trends of hsa-miR-4770 was consistent with the public database.
Conclusion
We identified hsa-miR-4770 as the characteristic miRNA for GBC. The ceRNA network of hsa-miR-4770 may play key roles in GBC. This study provided a little basis for potential pathogenesis of GBC.
Apatinib with first-generation EGFR-TKIs as second-line treatment for patients with advanced non-small cell lung cancer with acquired resistance: a retrospective case series analysis
Authors: Yimin Wu , Zhouyu Zhu , Jie Min , Chai Ying
Published: February 2023

Background: Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) develops in most patients with non-small cell lung cancer (NSCLC) and negates the effects of the drug. Herein we try to explore a feasible method for patients with acquired resistance to first-generation EGFR-TKIs.
Methods: This study primary assessed the efficacy of first-generation EGFR-TKIs combined with low-dose apatinib (a vascular endothelial growth factorreceptor-2 (VEGFR-2) TKI) in NSCLC patients with acquired resistance to EGFR-TKIs. We retrospect the clinical date of 50 NSCLC patientssuffering from gradual disease progression following efficacious targeted therapy using first-generation EGFR-TKIs. Patients received apatinib(250 mg, p.o.) once-daily with a first-generation EGFR-TKI (gefitinib or icotinib) until disease progression or unacceptable toxicity.The primary outcome measures the proportion of patients with a disease control assessed by the investigators according to RECIST 1.1.
Results: The median duration of observation was 7.5 (range, 1–20) months. The disease control rate was 90.0%, overall response rate was 32.0%. Hypertension, hand-foot syndrome, proteinuria and rash were the most common adverse events. Significant adverse events included hypertension and hemorrhage, only 2 patient quit the treatment because of adverse events. When disease progressed again after experiencing effective combined targeted therapy, patients could receive efficacious treatment with osimertinib or chemotherapy.
Conclusions: Our findings suggest that adding extra apatinib to first-generation EGFR-TKIs may prolong the effective duration of efficacy of first-generation EGFR-TKI. Besides, convenience and potential therapeutic safety advantages is also the advantages of our regimen.
Immersives Lernen in der Berufsschule
Authors: Tangocci Elena , Hartmann Christian , Bannert Maria
Published: February 2023

In der beruflichen Bildung ist das Arbeiten mit Virtual Reality (VR) und Augmented Reality (AR) von Vorteil, um gefahrlos Arbeitsvorgänge zu erlernen. Ein ausschlaggebendes Potenzial von VR- und AR-Applikationen ist die Möglichkeit, komplexe Lerninhalte realistisch bzw. dreidimensional zu repräsentieren sowie Interaktionsmöglichkeiten mit virtuellen Objekten darzustellen. VR- und AR-Applikationen können insbesondere Menschen mit Lernbeeinträchtigungen unterstützen, da diese Lerninhalte schlecht imaginieren können. Jedoch wurde bisher kaum erforscht, ob VR- und AR-Applikationen die Lernleistung kognitiv Beeinträchtigter tatsächlich fördern. Deswegen wurde an Berufsschulen mit sonderpädagogischen Klassen eine quasi-experimentelle Feldstudie im Prä-Posttest-Design durchgeführt um zu untersuchen, ob Auszubildende mit immersiven VR- und AR-Applikationen effektiver lernten als mit einem nicht-immersiven Tablet-PC und wer die höhere Motivation und Technologieakzeptanz aufwies. Die Ergebnisse zeigen, dass sich die Lernleistung der immersiven Lernbedingungen nur bei kognitiv anspruchsvolleren, prozeduralen und den Lerntransfer fördernden Lerninhalten signifikant von der Tablet-Bedingung unterschieden. Motivation und Technologieakzeptanz waren generell beim Lernen hoch. Insbesondere unterschieden sich die Lernbedingungen bei Interesse, der empfundenen Kompetenz und der Einstellung gegenüber dem Lernmedium. Diese Befunde zeigen, dass Menschen mit Lernbeeinträchtigung durch das Lernen mit VR- und AR-Technologie gefördert werden konnten. Basierend auf den Ergebnissen wird diskutiert, wie immersive Lernmedien effektiv für das Erlernen prozeduraler Inhalte im Unterricht eingesetzt werden können.
Probing extreme configurations in binary compact object mergers
Authors:   , Tootle Samuel
Published: February 2023

In this work the initial value problem for extremal binary compact objects is analyzed with application to the study of remnant stability in binary neutron star mergers. In limited respects this analysis is extended to the study of binary neutron stars using an equation of state with quark matter.
Analyses under the curve, identifying how invisible gold is held in pyrite
Authors: Gregory Daniel D.
Published: February 2023

When laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) analyses of pyrite plot below the gold solubility line on a gold vs. arsenic plot and have relatively flat counts on laser ablation time-resolved output graphs, it is often interpreted that the gold is held within the pyrite structure. The study by Ehrig et al. (2023, this issue) shows, using a combination of LA-ICP-MS spot analyses of gold in pyrite, transmission electron microscopy, and electron backscatter diffraction that this is not necessarily the case. Furthermore, they use these same techniques to identify how trace elements, including gold, are remobilized in pyrite during deformation and metamorphism.
Implementation of Character Education in Religious Culture: Multi-case study in Public and Islamic Junior High Schools
Authors: Noor Azizah Yunita
Published: February 2023

In an effort to internalize religious values in children’s character, a religious culture is needed in the school. This is because the portion of time given to Islamic subjects in schools is only relatively less on a weekly level, so the opportunities for teachers to provide guidance and direction are also relatively small. In addition, the religious values that exist in children are often defeated by the negative cultures around it. Therefore, character education in religious culture is considered to be able to shape the character of the students. This research aims to describe: (1) Character education planning on religious culture at State Junior High School 4 & Madina Islamic Junior High School (2) Implementation of character education on religious culture in State Junior High School 4 & Madina Islamic Junior High School. This research uses a qualitative approach using a multi-case study design. Data collection is conducted using in-depth interviews, observations & documentation. Research informants are principals of school, Islamic education teachers. The data obtained by the informant & the subjects studied were interpreted and analyzed using cross-case data analysis.  The findings of the study proved that: (1) Character education planning on religious culture at State and Islamic Junior High School is carried out using the standard set of character of students, forming religious culture, and providing supporting facilities, setting the standard competencies of graduates, and dividing the responsibility of mentor for each student. (2) The implementation of character education in religious culture in State Junior High School 4 is carried out using integrating the standard characters contained into the daily, weekly, monthly religious culture. And the application of character education in religious culture at Madina Islamic Junior High School is done using integrating the raw characters contained into the religious culture.
Topological quantum computation using analog gravitational holonomy and time dilation
Authors: Génetay Johansen Emil , Simula Tapio
Published: February 2023

Non-universal topological quantum computation models, such as the
Majorana fermion-based Ising anyon model, have to be supplemented with
an additional non-topological noisy gate in order to achieve
universality. Here we endeavour to remedy this using an Einstein­—Cartan
analog gravity picture of scalar fields. Specifically, we show that the
analog gravity picture enables unitary transformations to be realized in
two distinct ways: (i) via space-time holonomy and (ii) as gravitational
time dilation. The non-abelian geometric phases are enabled by
gravitational interactions, which are mediated by the spin-connection.
We analytically compute its matrix elements as a function of the scalar
field density distribution. This density can be regarded as the
gravitating distribution of matter in an analog universe. We show via
explicit calculations that there exists an infinite set of
asymptotically flat analog gravitational fields, each of which
implements a unique unitary transformation, that render the interactions
topological. We emphasise the generality of this result by asserting
that such gravitational gates could potentially be implemented in a
broad range of real systems modeled by scalar field with an acoustic
metric.
Role of NOS3 894G>T Gene Polymorphism in Traumatic Cerebral Hemorrhagic Contusion Khartoum, Sudan, 2020-2021
Authors: Hassan Ibrahim Samah Abdelrahman
Published: February 2023

The nitric oxide produced by the endothelial nitric synthase (NOS3) gene helps to maintain cerebral blood flow (CBF) after traumatic brain injuries (TBI). The aim is to determine the prognostic role of NOS3 894 G>T gene in traumatic hemorrhagic contusion and outcome. A cross-sectional study was conducted for 90 patients who attended the National Centre for Neurological Sciences, Khartoum, Sudan. Non-Sudanese patients, hemorrhagic contusions associated with other types of brain bleeding, and patients with chronic disease were excluded. An initial CT scan was used upon admission to detect brain edema, anatomical site, and the number of contusions. The Glasgow coma scale (GCS) was used upon admission to assess the trauma severity. The Glasgow outcomes scale (GOS) was used upon discharge to assess the outcome. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for NOS3 genotyping. The result shows that 93.3% of patients were male, while 32.2% of them were female. It further indicates that 58.9 % had a mild injury; 60% of the patients were presented with frontal lobe injury, 14.4% had multiple sites injury, and 22.2% had brain edema. The number of deaths was 8 (8.9%). The genotyping of NOS3 revealed that 94.4% of patients had homozygous GG and 5.6% heterozygous GT. G allele represented 97.2% of NOS3 alleles. NOS3 894 G>T genotypes were not significantly associated with patients, linguistic afflation’ and outcome. The study concluded that NOS3 894G>T gene has no prognostic role in traumatic hemorrhagic contusion and outcome. Keywords: Nitric oxide synthase gene, Traumatic brain injury, Glasgow coma scale, Glasgow outcomes scale.
Linguistic terminology in lexicography: the experience of the gizaurus description
Authors: Mayorov Aleksandr P.
Published: February 2023

The review of S. V. Lesnikov’s “The Metalanguage of Linguistics” (2021) seems relevant due to the demand for such a genre of lexicographic representation of linguistic terminology today. The genre of the hysaurus itself in contemporary reference literature is distinguished by scientific novelty, therefore, the review pays special attention to the characteristics of the formal and substantive features of the hysaurus. Lesnikov’s work, created specifically to be used digitally, contains the following features of a dictionary: hypertext, expanded dictionary descriptions, multimedia, interactivity, and updatability. All the while, a significant achievement of S. V. Lesnikov’s work is the preparation of a printed version, which serves as an additional format for a digital ideographic dictionary on linguistic terminology, which involves the analysis and refinement of lexicographic information in an interactive format. The review notes other advantages of this type of lexicographical work. The reaction of the hysaurus to the expansionism and interdisciplinarity of modern linguistics is manifested in the coverage of three groups of terms: 1) special terms used only in linguistics; 2) terms of related branches of knowledge denoting the concepts necessary for a given subject area; 3) general scientific terms that exist in any branch of knowledge. The infographics used in the hysaurus is methodologically effective as it shows the reader the results of the lexicographical research. The depth of S. V. Lesnikov’s systematization of the terminological system of the metalanguage of linguistics shows the current development of linguistics as a science of the language. This review contains several remarks that are inevitable for this kind of research. Namely, the reviewer notes the problem of the principle of selection of vocabulary in the dictionary, the violation of the system in the presentation of material, the discrepancy between the electronic and paper versions of the hyasaurus on the example of narrative.
Indirect speech acts of modern communication: speech genre of hidden request
Authors: Bagirova Elena P. , Gavrikova Elina O.
Published: February 2023

This article analyzes the phenomena that have developed in the field of expressing will in contemporary speech communication. Namely, the illocutionary goals of imperative indirect speech and ways of implementing indirect imperativeness at the lexical and grammatical levels. Additionally, the authors describe markers of hidden forms of motivation and factors, which determine the degree of motivation, and reveal non-imperative forms of motivation. The theoretical basis of the work includes the works by N. I. Formanovskaya, A. Vezhbitskaya, J. Searle, M. Ya. Blokh , G. G. Yarmarkina and other researchers of the phenomenon of directive speech acts. The article analyzes request forms in indirect speech presented as declarative and interrogative sentences. The authors establish that communicative acts expressing will are implemented by a variety of linguistic means and models aimed at softening the expression of a request. For example, among declarative sentences, there are constructions with the lexeme хочу (“I want”), predicative adverbs надо (“need”), нужно (“necessary”), etc.; among interrogative sentences — interrogatives with the modal part правда (“truth”), modal constructions with хотеть (“want”) and мочь (“to be able”), indirect directives containing the interrogative indicative of the verb of the causal action with the negative particle не (“not”). A speaker’s choice of a specific means and form of request affects its assessment as categorical, neutral, polite and over-polite.
TRUTHFUL DREAMS OF ANDREY ARZHILOVSKIY: FROM A 1936-1937 DIARY OF A MAN SENTENCED TO DEATH
Authors: Nikulina Nadezhda A.
Published: February 2023

The paper is based on the description of dreams laid down in a 1936-1937 diary of a Siberian village dweller Andrey S. Arzhilovskiy. Andrey S. Arzhilovskiy (1885-1937) was a prominent representative of peasants’ intelligentsia of the late empire period, whose interests extended beyond breadwinning: being engaged in volost paperwork, he composed articles and satire for local newspapers, recounted folk customs and rites, and occasionally kept a thoughts’ journal. For being involved in the work of a uyezd administration, he was first convicted in 1920 before being granted amnesty in 1922 and convicted for the second time in 1929, the latter sentence having led to over seven years of camp imprisonment. During this period, Arzhilovskiy has kept a diary, noting all his mundane observations, parenting turmoil, and doubts concerning a newly-established pattern of life and thought. The description of night dreams constitutes an important part of this egodocument which brought its author into scandalous limelight when it was partially published in the U.S. in 1995 and, at the same time, gave rise to the interpretation of key signs and symbols of individual and public history. Remarkably, this diary came to arise as grounds for its owner’s guilty verdict pursuant to his life ended in the NKVD confines in 1937.
A VIRTUAL IMAGE OF AN ARCTIC TOWN (THE CASE STUDY OF SALEKHARD)
Authors: Dolgikh Anastasia I.
Published: February 2023

The paper is concerned with a virtual image of an Arctic town as exemplified by Salekhard. Arctic discourse is extensively researched in contemporary humanities and social studies. The Arctic is being conceptualized as a unique region of circumpolar civilization, and its sustainability is considered a national issue of strategic importance, particularly in terms of the prosperity of Arctic towns, which have received a significant investment to shape their brands and identities. The above-mentioned trends are key to understanding the relevance of the study. However, few Russian researchers have previously dealt with the issues of shaping, preserving, and developing Russian Arctic towns’ unique identity and representation in a virtual space. This paper seeks to contribute to this area of research. Hence, the paper is aimed at identifying key characteristics of an Arctic town’s virtual image as represented by Salekhard, the administrative centre of the Yamalo-Nenets Autonomous Okrug located in the Arctic zone of the Russian Federation. To explore Salekhard’s virtual image, the author has adopted a contextual analysis of data retrieved from January to June 2022 through parcing the official community of Salekhard’s municipality administration on the social networking service VK (VKontakte) facilitated by VK API. In terms of the study’s findings, the specific components shaping the image of Arctic towns are presented; the notion of ‘a town’s virtual image’ is defined; key topics, most popular hashtags and most frequent lexemes are revealed by means of contextual analysis; evaluative and functional dominants of VK posts that affect Salekhard’s image are identified; building upon this, authentic features of Salekhard as an Arctic town are outlined. In conclusion, emphasis is placed on peculiar features of the representation of Arctic discourse in a virtual space based on the explored data, contextual conditions of shaping, developing and promoting the town’s virtual image, and major components that constitute this image.
THEODORUS THE GREEK, THE POPE’S MITROPOLICH’ OF ROME. REVISITING THE RELATIONS BETWEEN RUS AND THE PAPACY IN THE LATE 11TH CENTURY
Authors: Khrustalev Denis G.
Published: February 2023

The paper gives grounds for the viewpoint that historians can treat as probably valid the record in the Nikon Chronicle dated 6599 Creation Era (1091 CE) reporting the arrival of Theodorus the Greek’s papal mission from Rome in Kyiv with numerous saints’ relics. Arguments are put forward in favour of Theodorus’ identification with Pope Urban’s legate Teuzo, cardinal of San Giorgio in Velabro, who could have been set off to Rome, accompanied by Prince Yaroslav Sviatopolchich, whom the former could have met at the consecration of St. Egid Basilica in Somogyvár. This mission could be juxtaposed with the translation of the relics of Saint Nicholas from Myra to Bari and its commemoration being established as a Church holiday (May 9 Julian Calendar).
Urban Green Spaces in Brazil: challenges and opportunities in the context of the COVID-19 pandemic
Authors: Da Silva Romero Gomes Pereira , Lima Cláudia Lins , Quinn Sterling D. , Afelt Aneta , Laques Anne-Elisabeth , Saito Carlos Hiroo
Published: February 2023

During the COVID-19 pandemic, urban green spaces were considered less prone to contagion, and thus people adopted them as alternative sites for improving mental health. The One Health concept advocated by health organizations worldwide supports the idea that the well-being of urban residents is strongly linked with physical activity in green areas. As the world grapples with the physical and mental health consequences of the COVID-19 pandemic, it becomes clearer that access to urban green spaces is a human rights issue. This study compared previously-mapped urban green spaces in five metropolitan regions in Brazil with the results of an extensive survey of municipal managers concerning possible increase in demand of population for green spaces. Urban green spaces of over 625 m2 were mapped in 117 municipalities, the total area of 4170 km2 representing 37.4% of the urban spaces analyzed in the five  metropolitan regions. Out of these 117 municipalities, 49 had data available concerning demands of green spaces in the pandemic context. Overall, 20 municipalities (representing all five metropolitan regions) stated that there was an increase in visitation in urban green spaces, and 13 more indirectly suggested possible demands. When sustainability transitions are understood as geographical processes that happen in concrete places, urban green spaces then represent real locations where sustainable transitions can begin. The unequal distribution of these spaces also brings into consideration a social justice perspective, as well as aspects of public health that involve climate change resilience and epidemiological risk (SDG 11).
Особенности жизнестойкости современного человека в эпоху пандемии
Authors: Ельникова Оксана Е. , Пронина Анжелика Н. , Фаустова Ирина В. , Комлик Любовь Ю.
Published: February 2023

Введение. В статье поднимается актуальная проблема нестабильности и неопределенности современного мира, связанная с возникновением пандемии и последовавшими вслед за ней социальными ограничениями, в частности – влияние уровней компонентов жизнестойкости на эффективность поведения представителей помогающих профессий в эпоху VUCA, что не было изучено ранее. Целью экспериментального исследования стало изучение особенностей жизнестойкости различных групп населения в ситуации пандемии. Методы. В исследовании использовался оригинальный вариант теста жизнестойкости (Hardiness Survey) С. Мадди в адаптации Д. А. Леонтьева, Е. И. Рассказовой. Экспериментальное исследование проводилось в г. Елец Липецкой области, в нем приняли участие 360 человек (девушки и женщины). Выборку составили представители разных социальных групп: студенты, педагоги общеобразовательных организаций, работники социальной сферы и здравоохранения (равное количество от каждой группы). Статистический анализ результатов проводился с использованием однофакторного дисперсионного анализа, t-критерия Стьюдента с помощью пакета программы SPSS-21. Результаты. Результаты исследования показали, что большинство студентов и педагогов, принявших участие в эксперименте, имеют высокий уровень жизнестойкости, при этом у трети представителей этих групп зафиксирован низкий уровень; медицинским работникам в равной степени присущи высокий и средний уровни, а работники социальной сферы продемонстрировали практически одинаковые показатели как высокого, так и низкого уровней. Полученные данные позволяют сделать вывод о более развитых показателях жизнестойкости у медицинских работников. Однако статистический анализ результатов свидетельствует о том, что уровень жизнестойкости не зависит от типа занятости респондентов. Обсуждение результатов. Анализ степени выраженности того или иного компонента жизнестойкости у участников эксперимента показал, что доминирующим является «контроль». Это указывает на то, что подавляющее большинство респондентов убеждены – мобилизация внутренних сил позволит им адаптироваться в ситуации неопределенности и справиться со стрессовыми обстоятельствами жизни.
Динамика супружеских и родительских отношений в семьях, зачавших ребенка посредством экстракорпорального оплодотворения
Authors: Лещинская Светлана Б. , Стоянова Ирина Я. , Бохан Татьяна Г. , Терехина Ольга В. , Силаева Анна В.
Published: February 2023

Введение. Увеличение распространенности вспомогательных репродуктивных технологий повышает исследовательский интерес к психологическим особенностям семей, зачавших ребенка с помощью экстракорпорального оплодотворения (ЭКО), как значимому фактору, определяющему его здоровье и благополучие. Однако имеющиеся данные разрозненны и противоречивы. Исследование направлено на выявление специфики и динамики супружеских, родительских отношений и психологического благополучия супругов, зачавших ребенка посредством ЭКО, в период ожидания ребенка и в его младенчестве. Методы. Выборку составили 250 семейных пар: 160 семей с естественным зачатием и 90 семей с индуцированной беременностью. Использован комплекс методик, направленный на диагностику супружеских, родительских отношений и аффективного компонента отношений родителей в период беременности и в младенческом возрасте ребенка. Результаты. На обоих этапах исследования выраженные значимые различия супружеских отношений между типами семей отсутствовали, тогда как родительские отношения в семьях с ЭКО характеризовались значимо более выраженным благополучием и свидетельствовали о высокой ценности родительства. В период беременности в каждой из групп выявлено 2 типа семей: в основной группе – «благополучие супружеских и родительских отношений» (58 %) и «супружеское неблагополучие при высокой ценности родительства» (42 %), в контрольной группе – «благополучие супружеских и родительских отношений» (67 %) и «супружеское и родительское неблагополучие» (33 %). Специфика типов семей сохранялась на протяжении младенческого возраста ребенка. Обсуждение результатов. Результаты свидетельствуют об отсутствии выраженной связи супружеских отношений с типом зачатия ребенка, обусловленности их динамики прохождением кризисного этапа жизненного цикла семьи, а не методом достижения беременности. Напротив, родительские отношения в семьях с ЭКО обладают спецификой, проявляющейся в их ценности и относительной независимости от других аспектов семейного функционирования. Полученные новые данные могут быть использованы в процессе психологического сопровождения семей, воспользовавшихся ЭКО.
Проектирование образовательной среды вуза для развития предпринимательских компетенций студентов
Authors: Махмутова Елена Н. , Воронина Раиса Н.
Published: February 2023

Введение. Одним из приоритетов образовательной среды вуза становится формирование компетенций студентов, связанных со способностью профессионального развития в условиях социально-экономической неопределенности. Предпринимательские компетенции могут значительно повышать ценность студентов всех специальностей на рынке труда и результативность их профессиональной деятельности. Целью проведенного исследования является проектирование образовательной среды вуза для развития предпринимательских компетенций студентов на примере Севастопольского государственного университета (СевГУ). Методы. На основе методов систематизации и классификации отечественного и зарубежного опыта предпринимательского образования в вузах для проектирования образовательной среды применялись принципы дизайн-мышления (с использованием фокус-групп), визуализации. Оценка предпринимательских предпочтений студентов проведена методом опроса 821 студента СевГУ различных специализаций с последующим частотным семантическим анализом ответов. Результаты. Разработана модель образовательной среды для развития предпринимательских компетенций студентов с обозначением целевых результатов и рекомендуемого состава необходимых организационно-педагогических условий. Предпринимательские предпочтения выявлены у 29,4 % студентов независимо от их профессиональной специализации. Обсуждение результатов. Новизна проведенного исследования в теоретическом аспекте заключается в конкретизации фактора личностно-средового профессионального взаимодействия вузовской молодежи в виде предпринимательских компетенций студентов. В прикладном аспекте разработана авторская модель образовательной среды для развития предпринимательских компетенций студентов, которая может быть адаптирована и использована вузами для проектирования организационно-педагогической инфраструктуры при обучении студентов независимо от их профессиональной специализации. Основные этапы проектирования образовательной среды: выявление ключевых переживаний студентов с использованием принципов дизайн-мышления; определение целевых результатов освоения предпринимательского трека с моделированием состава необходимых организационно-педагогических условий образовательной среды; идентификация и исследование контингента студентов различных специальностей, заинтересованных в развитии предпринимательских компетенций.
Macrolinguistics: texts and discourses, conversation interactions and conversation components
Authors: Zulvany Valentine
Published: February 2023

This study aims to explore macrolinguistics based on the realm of text with lexical and grammatical means. Also to analyze contrastive texts with textual characteristics, text typology, and translated texts. Some of the other things discussed are ways to analyze discourse, interactions in conversations, and know the components of conversation. Language studies continue to develop from time to time. One of the studies that cannot be separated from language is linguistic studies. The study of linguistics in a language not only covers linguistics from an internal point of view but can also be related to linguistics in general. Macro linguistics in this case is not associated with other disciplines outside of linguistics, but a linguistic study that examines speech based on situations.
History and field linguistics
Authors: Zun Xin Zang
Published: February 2023

This study aims to understand the history and fields of science in linguistics. Until the Renaissance, the languages studied were Greek and Latin. Latin had an important role at that time because it was used as a tool in the world of education, administration, and international diplomacy in Western Europe. During the Renaissance, language research began to develop into Romance languages (French, Spanish, and Italian) which were considered to have Latin roots, as well as non-Roman languages such as English, German, Dutch, Swedish, and Danish.
COMPUTER SIMULATION INVESTIGATION OF CRASH BOX DESIGN AS SAFETY-PROTECTION TECHNOLOGY FOR INDONESIA HIGH SPEED TRAIN
Authors: Musyaffa Dzikri Amali , Choiron Moch. Agus , Irawan Yudy Surya , Hidayati Nafisah Arina , Taryono Taryono , Gorbatyuk Sergey
Published: February 2023

The crashworthiness of a railway vehicle has been developed to provide energy absorption capacity and efficiency of energy absorption. This study presents a computer simulation to determine the energy-absorbing structure of the new addition of a crash box design on the Indonesian high-speed train in a collision scenario. The crashworthiness analysis in the crash box is done with software based on finite element methods. The crash box is modeled as a thin-walled structure located in coupler housing, between the draft gear and the car frame. The test model was carried out according to the 2019 SNI 8826 standard using a frontal impact test with an impactor mass of 38.807 kg and a speed of 10 m/s. The pattern of deformation and energy absorption is obtained by calculating the area under the graphical curve of the relationship between the force reaction and the displacement obtained from the simulation. The deceleration of the train is obtained from the graph of acceleration against time on the impactor. The simulation results show that the addition of a crash box design as an energy absorption module on a safety protection technology for railway vehicles can reduce the severity of the impact and improve passenger safety. The application of the initial crash box model also shows an unacceptable train deceleration in the SNI 8826 test standard.
INCREASING PROFITABILITY OF A MANUFACTURING COMPANY BY USING THE TOTAL PRODUCTIVE MAINTENANCE APPROACH: A REVIEW
Authors: Risonarta Victor Yuardi , Wardhani Angelia Kusuma
Published: February 2023

In the modern world, a company pays serious attention to productivity and efficiency. Several sectors in the manufacturing world are starting to carry out business transformation, particularly those leading to industry 4.0. This circumstance is driven by efforts to achieve higher productivity and an efficient process, mainly after being economically hit by the Covid-19 pandemic. To maintain efficiency, a manufacturing company should maintain its machine and equipment. Total productive maintenance is a system based on the concept of preventive and predictive maintenance. It is designed to prevent loss resulting from many factors, e.g. production interruption due to failures and adjustments, speed loss due to minor stops and speed reductions, and loss due to defects. Total productive maintenance also provides a tool to measure the level of effectiveness of a machine, i.e., overall equipment effectiveness. This review article focusses on the application of total productive maintenance and overall equipment effectiveness to determine the effectiveness of equipment and eliminate the factors that affect the effectiveness of the equipment.
COMPARISON OF CHATTER CONTROL OF VARIABLE AND REGULAR HELIX TOOLS IN THE ALUMINUM END-MILLING PROCESS
Authors: Sonief Achmad As’ad , Ma'arif Moch. Syamsul , Pratikto Pratikto , Juliano Hans
Published: February 2023

In the chatter, machining operations are undesirable because of the phenomena that affect product results, machining accuracy, tool life, and high operating value. Chatter is a vibration phenomenon that occurs in cutting tools due to the self-excitation of the influence of cutting parameters during the operation process of the machine. Types of chatter in machinery are regenerative and resonant. Because the pitch angles of variable helix tools vary, the helix angles of variable tools produce different tooth passing frequencies on each tool eye next to each other and can be used to prevent and control resonance. This study aimed to compare chatter control from the variable helix and regular-angle tools in the aluminum end milling process. The method is carried out through the end milling process experiment to determine the chatter control of the variable helix and regular-angle tools through the stability loop diagram. The results from this study were obtained by comparing control chatters in the milling process through controlling variable and standard helix angles as a guideline to produce the best surface roughness in the end milling process made from aluminum. The comparison of estimated control charts from variable helix tools is more comprehensive than regular helix tools.
STRESS DISTRIBUTION ANALYSIS ON LIGAMENT AUGMENTATION AND RECONSTRUCTION SYSTEM (LARS) USING FINITE ELEMENT METHOD (FEM)
Authors: Aulia Fauzan , Sonief Achmad As’ad , Hidayati Nafisah Arina , R Sanjay M
Published: February 2023

The Ligament Augmentation and Reconstruction System (LARS) is a prosthetic device used to support knee ligaments severed due to injury. The role of LARS in supporting the knee ligaments is to take over the position of the natural ligaments that have been severed, binding the thigh bone and shin bone. LARS is made from polyethylene terephthalate (PET) material, commonly used in industry. LARS is a prosthetic product widely used to heal ligament injuries. However, despite its everyday use, no one has confirmed whether LARS can support a severed ligament. There has never been a study analyzing this tool, even from the company that makes LARS. They only state that LARS is safe and suitable for healing ligament injuries. Therefore, a LARS analysis is needed to convince the public that the tool is safe. This study analyzed the stress distribution in LARS during the standing-to-squatting condition. The results show an uneven stress distribution between the LARS inside the femur and other parts of the LARS. However, the stress distribution is still in a safe condition that does not directly reduce the strength of the LARS.
Conciliation procedures in procedural law and legislation (on the example of judicial mediation and judicial reconciliation)
Authors:   Natalia Vl. Tyumeneva Saratov National Research State University named after N.G. Chernyshevsky, Tyumeneva Natalia Vl.
Published: February 2023

The article examines the role of conciliation procedures in civil, arbitration and administrative processes, as well as the specifics of judicial mediation and a new conciliation procedure – judicial reconciliation with the participation of a judicial conciliator. It is noted that the institutionalization of conciliation procedures and the expansion of their types are necessary to optimize the judicial process and strengthen its dispositive principles. A comparative analysis of judicial mediation and judicial reconciliation is carried out. The article considers the unity of their principles, consensuality, partial integration into the judicial process, non-jurisdictional nature; the active role of the mediator and the judicial conciliator during the mediation and judicial reconciliation procedure; a high degree of self-regulation by the parties. The differences between judicial mediation and judicial reconciliation in the order of conduct are substantiated, as well as the differences in the legal status of the mediator and the judicial mediator are explained. The necessity of fixing the measures of responsibility for the judicial conciliator in the implementation of the judicial reconciliation of the parties is substantiated. The conclusion is made about the prospects of mediation and judicial reconciliation in the legal system of Russia.
Ensuring the security of assistance to the investigation as an independent condition for the conclusion of a pre-trial cooperation agreement with the suspect, accused
Authors:   Veronika V. Kolesnik Rostov Branch of the Russian State University of Justice, Kolesnik Veronika V.
Published: February 2023

The stimulation of the criminal procedure conduct of persons against whom criminal prosecution is carried out has various forms. Assistance to the criminal prosecution authorities, especially in pre-trial proceedings, is essential for a high-quality, effective investigation of the circumstances of the criminal case. The conclusion of a pre-trial cooperation agreement (DSoS) between the prosecutor and the suspect or accused creates conditions as an increase in evidentiary activity, but also a threat to the person who concluded it. In this regard, it seems that an important circumstance of the content of the agreement is the condition for safe assistance to criminal justice. Safe and active assistance to the investigation creates threat to life, health, other legitimate interests of the suspect or accused. These threats can be of different nature (forms, types). It is assumed that the specified security provision should be a mandatory and necessary condition for the content of the agreement.
Information security as an integral part of the national security of the Russian Federation constitutional and legal aspect
Authors:   Zulfiya I. Alieva Dagestan State University, Alieva Zulfiya I. , Hasbulatova Zarema M. ,   Zarema M. Hasbulatova Dagestan State University
Published: February 2023

The article studies modern constitutional and legal aspects of information security in the structure of the national security of the Russian Federation. The main interrelations are revealed, and a general assessment of the current situation in the information security of Russia is given. The problems and trends in improving the regulatory legal acts regulating the information security of the Russian Federation and our enterprises from the standpoint of strengthening national security in the medium term have been studied. Recommendations are proposed for improving the existing tools of the constitutional and legal aspect of information security as an integral part of the national security of the Russian Federation
Features of the financial and legal status of the subjects of the Russian Federation
Authors:   Naida M. Ataeva Dagestan State University, Ataeva Naida M.
Published: February 2023

In the article, the author analyzed the features of the financial and legal status of various subjects of the Russian Federation. When writing the article, the following research methods were used: logical, formallegal, method of legal modeling and analysis. In conclusion, it is concluded that Russia as a federal state consists of subjects, each of which has its own financial and legal status, which is established by both federal and regional legislation. Such a situation has an objective necessity due to the heterogeneous, multinational composition of the Russian Federation, historical-geographical, spiritual-confessional, ethno-cultural and socio-economic reasons and conditions of each region, which led to the formation, construction and development of the Federation on the principles of asymmetry. This principle makes it possible to take into account all the specific and essential features of each subject of the Federation when they carry out financial activities.
Dagestan State University – Center of Legal Science and Education: History and Modernity
Authors:   Tazhutdin B. Ramazanov Dagestan State University, Ramazanov Tazhutdin B.
Published: February 2023

The scientific article is devoted to the study of the long-term scientific and educational activities of the scientific and pedagogical staff of the Faculty of Law (Institute) Dagestan State University. For 50 years, the team has prepared hundreds of monographs, textbooks and scientific articles devoted to the problems of the rule of law, the protection of human rights and freedoms, the protection of natural resources, the improvement of statehood, the development of civil law and process, countering extremism and terrorism, the protection of families and minors, the development of problems of criminal responsibility and punishment, the study of crime and measures to combat with her, the study of financial and tax relations, the development of the information society and digital economy, etc. The article focuses on the history of the formation of the institute and the memory of scientists and teachers who stood at its origins.