bluuebunny/crossref_metadata_2025 huggingface dataset:
BLOCKCHAIN Y COOPERACIÓN PROCESAL INTERNACIONAL: NUEVAS POSIBILIDADES PARA EL ASEGURAMIENTO Y CONSERVACIÓN DE PRUEBAS ELECTRÓNICAS
Authors: Bueno De Mata Federico
Published: June 2024

El uso de las TICs en la cooperación jurídica penal internacional: construyendo la Sociedad digital de futuro es una obra colectiva fruto de la investigación en el marco del Proyecto de Excelencia «El uso de las TICs en la cooperación jurídica penal internacional: construyendo la sociedad digital andaluza del futuro (PAIDI-PY18-1059)», coordinado por la Dra. Leticia Fontestad Portalés. Partiendo de la idea de que los instrumentos de cooperación judicial penal internacional no pueden quedarse rezagados en el proceso de digitalización de la Justicia, se estudia en esta obra la transformación digital de la Justicia española, así como el intercambio electrónico transfronterizo de datos a través del sistema e-CODEX, consecuencia de la cooperación judicial internacional en red. Datos que, también deben ser objeto de protección a la luz de la Directiva UE 680/2016 y la Ley 7/2021. Se ofrece, igualmente, el examen de cuestiones de indudable actualidad como son la prueba electrónica en los procesos penales transfronterizos, el uso del blockchain para el aseguramiento y conservación de las pruebas electrónicas, el análisis de la «cooperación» penal internacional entre fiscales europeos delegados en el ámbito de la prueba transfronteriza a través de las nuevas tecnologías, las medidas tecnológicas de investigación en relación con las órdenes europeas de investigación o el análisis de los instrumentos y las posibilidades de la inteligencia artificial en el ámbito de la cooperación judicial penal internacional.
SIYOSIY INSTITUTLAR VA JARAYONLARNI ILMIY TADQIQ ETISHGA BO‘LGAN YONDASHUVLAR
Authors: Miralisher XASANOV
Published: June 2024

Mazkur maqolada siyosiy institutlarning mamlakat taraqqiyoti uchun ahamiyati, davlat hokimiyatining mavjudligi hamda davlat o‘z faoliyati bilan jamiyatning barcha a’zolarini qamrab olishi, barcha tabaqalar va ijtimoiy guruhlar manfaatlarini to‘la ifodalashi, hayotning turli sohalarini tartibga soluvchi keng boshqaruv apparatini shakllantirishi kabi tadqiqot yo‘nalishlari, boshqaruv tizimida aynan davlatga “Institutsionallashgan hokimiyat” sifatidagi ilmiy-nazariy tadqiqotlar borasidagi izlanishlar asoslandi.
TALABALARANING IJTIMOIY FAOLLIK KO‘NIKMALARINI TAKOMILLASHTIRISHDA TARIXIY BILIMNING AHAMIYATI
Authors: Maftunaxon ERGASHEVA
Published: June 2024

Mazkur maqolada ta’lim muassasalar va talaba yoshlardagi ijtimoiy faoligni takomillashtirishda tarixiy bilimlarning o‘rni va tarbiya jarayonlarini tashkil etish ahamiyatini oshirish va yoshlardagi ijtimoiy faollik ko‘nikmalarini oshirish to’g’risida fikr yuritiladi.
THE USE OF PARTICLES IN LINGUISTICS, THEIR EXPRESSION AS LINGUISTIC UNITS
Authors: Saule ISHANOVA
Published: June 2024

This article reveals the grammatical features of particles as part of speech and their application in a linguistic unit, a detailed examination of subjects in a wide application on semantic dependence, and also reflects the differences and similarities between the views of scientists about particles.
RESTORONIMLAR VA ULARNING MILLIY – MADANIY XUSUSIYATLARI (TOSHKENT SHAHRI OVQATLANISH SHAHOBCHALARI MISOLIDA)
Authors: Navruza MAMAJONOVA
Published: June 2024

Ushbu maqolada joy nomlarinin bir tarmog‘i hisoblangan restoronimlarning milliy-madaniy xususiyatlari Toshkent shahridagi restoran nomlari misolida tahlil qilingan. Bunda restoran nomlarining kelib chiqish tarixi ham yoritilgan.
Pengaruh Pengajaran Pendidikan Agama Kristen dan Spiritualitas Guru Agama Kristen Berdasarkan Titus 2:6-8 Terhadap Pertumbuhan Karakter Kristiani Siswa SMAN 1 Wamena
Authors: Barasa Chrisna Mikhayani , Minggus Minggus
Published: June 2024

The research is based on the results of observations of the behavior of high school students, Wamena, who easily imitate what they see from;  including religious teachers.  Many students do things that are inappropriate for children their age. Researchers suspect that student behavior is related to a less serious attitude when participating in learning.  Research was conducted to prove the truth of the hypothesis, it is suspected that there is an influence of teaching Christian religious education based on Titus 2:6-8 and the spirituality of Christian religious teachers on the growth of Christian character of students at SMAN I Wamena.  This type of research is quantitative research with a descriptive analysis approach. The sample in this study amounted to 64 respondents with a sampling technique based on Simple Random Sampling. The research results show that the influence of religious education teaching based on Titus 2:6-8 on the growth of students' Christian character is o.792 or 79.2%, which shows an influence in the high category. The influence of Christian religious teacher spirituality based on Titus 2:6-8 on the growth of students' Christian character at Wamena 1 State High School is 0.975 or 97.5% which is included in the high category. Then, the influence of teaching Christian religious education and the spirituality of Christian religious teachers based on Titus 2:6-8 on the growth of students' Christian character at SMA Negeri 1 Wamena is 0.941 or 94.1% which is included in the high category.
Strategi Pengembangan Kawasan dengan Konsep Jenama Tematik Berkelanjutan
Authors: Garudea  , Ardina Putri Pakiding Hana , Antony Febrian R. , Rifka Nonny
Published: June 2024

Keberlanjutan perkotaan umumnya diartikan sebagai upaya menyeimbangkan berbagai aspek seperti meningkatnya kepadatan pemukiman, semakin intensnya percampuran kelompok sosial dan aktivitas fungsional, serta berkurangnya mobilitas spasial. Oleh karena itu pengembangan kawasan menjadi sangat perlu dilakukan. Sebuah strategi yang menggabungkan nilai keberlanjutan dan eksplorasi identitas tempat merupakan salah satu cara untuk menjawab persoalan tersebut. Jenama kota/kawasan tematik dapat menjadi dasar untuk menemukan ide pokok sebelum diturunkan menjadi berbagai wujud pengembangan kawasan agar citra kawasan yang khas dapat terbentuk. Analisis kondisi dan potensi akan menjadi langkah awal sebelum melakukan analisis pemilihan jenama tematik dan analisis wujud keberlanjutan. Dengan studi kasus Kampung Celaket di Malang sebagai Kampung Kuno, penelitian ini akan mencoba mengidentifikasi langkah-langkah dan menyusun strategi agar jenama tematik kawasan kampung kuno dapat tercapai. Simpulan langkah-langkah dari penelitian ini dapat digeneralisir menjadi strategi pengembangan kawasan  dengan konsep jenama tematik berkelanjutan.
Konsep Eco-Settlements Pada Kawasan Permukiman Nelayan Bulak
Authors: Sahbani Evita Andriani , Prakasa Darmansjah Tjahja , Faisal Muhammad
Published: June 2024

Permukiman nelayan merupakan lingkungan tempat tinggal dengan sarana dan prasarana dasar yang sebagian besar penduduknya merupakan masyarakat yang memiliki pekerjaan sebagai nelayan dan memiliki akses dan keterikatan erat antara penduduk permukiman nelayan dengan kawasan perairan sebagai tempat mereka mencari nafkah, meskipun demikian sebagian dari mereka masih terikat dengan daratan. terlihat konsep eco-settlements mengarah pada pencapaian nilai ekologis. Dalam penerapannya konsep ini harus mengharmonisasikan tiga pilar berkelanjutan yaitu sosial, ekonomi, dan ekologi. Dimana pada Kawasan Bulak ini memiliki potensi yang besar, terutama dalam sektor wisata. Kawasan yang berada di area wisata kota Surabaya menjadikan kawasan permukiman nelayan Bulak ini dapat menjadi wisata baru dan pendukung bagi wisata di sekitarnya. Dengan berbagai kearifan lokal dan kehidupan nelayan sehari-hari yang dapat menjadi daya tarik tersendiri bagi kawasan ini. Pendekatan eco-settlement berfungsi sebagai pijakan dalam mencapai permukiman yang ekologis melalui 3 pilar ekologi, sosial dan ekonomi dengan dukungan dan kerja sama dengan institusi. Eco-settlement memiliki kriteria yang mengacu pada prinsip arsitektur ekologis, yang diharapkan dapat menciptakan permukiman nelayan yang berkelanjutan. Dengan menggunakan metode penelitian deskriptif kualitatif serta pengumpulan data. Maka didapatkan hasil dimana lingkungan peermukiman nelayan Bulak masih memiliki permasalahan pada elemen ekologi yaitu : ekologi, ekonomi dan sosial. Selain itu permasalahan penggunaan lahan yang maish belum sesuai dengan peraturan daerah yang ada.
Kajian Tentang Pendekatan Ekologi Arsitektur Pada Rancangan Rumah Susun
Authors: Andarwati Ratna Armelia , Rolalisasi Andarita , Murti Farida
Published: June 2024

Dalam mendesain atau merancang sebuah bangunan terdapat beberapa aspek yang harus diperhatikan dan dipertimbangkan, seperti pengoptimalan pencahayaan, pengoptimalan penghawaan, vegetasi, efisiensi energi, meminimalkan radiasi matahari yang masuk ke dalam bangunan, dan penataan area hijau. Pada saat semua elemen ini menjadi satu dalam sebuah rancangan akan menghasilkan kenyamanan dan berdampak pada kesehatan fisik maupun mental, tentunya itu semua merupakan dampak positif dari penerapan terhadap bangunan. Dengan memanfaatkan semua aspek tersebut, bangunan juga dapat menghemat energi dan ramah terhdap lingkungan. Permasalahan utama yang dihadapi disetiap perkotaan adalah lahan yang semakin sedikit. Solusi untuk masalah ini adalah membuat perumahan vertikal di perkotaan. Penelitian ini bertujuan membahas penerapan konsep arsitektur ekologis terhadap hunian vertical. Dengan adanya penelitian ini, diharapkan dapat merancang sebuah bangunan dengan prinsip arsitektur ekologis sebagai acuan dalam merancangan sebuah bangunan hunian vertikal.
Analysis of Patients Receiving Treatment for Inflammatory Breast Disease at Surgery Department of Tertiary Care Units
Authors: Rashid Muhammad , Shahbaz Muhammad Nasir , Akram AMNA , Anwar Awais , Umar Muhammad , Ali Muhammad Shazib , Mujahid Asfand Yar
Published: June 2024

Abstract: Background: In the Surgery Department of Tertiary Care Units, an analysis of patients receiving treatment for inflammatory breast disease presents a critical assessment of disease patterns and therapeutic outcomes. This evaluation is pivotal in understanding the prevalence and efficacy of treatment modalities in addressing complex breast conditions within specialized care settings. Aims and Objectives: To assess the effectiveness of the care given to mastitis and breast abscess patients admitted to the surgical department of the Sir Gangaram Ram Hospital Lahore. Study Design: Prospective Analytical Cross-sectional Study. Place & duration of study: Current study was conducted in surgical department of the Sir Gangaram Ram Hospital Lahore from March 2023 to December 2023. Methodology: The patients those visited and admitted with a diagnosis of breast abscess were included regardless of age, size of the abscess and co-morbidities. The patient was informed of the available treatment options, and their priority was taken into account for the chosen course of action. Total 100 female patients were divided in two different groups. In group-A 60 patients were operated with local anesthesia and their abscess size was larger than 2.5 cm in diameter. While in group-B, 40 patients were conservatively managed and either ultrasound guided aspiration or no intervention is used. Either the size of the abscess was less than 2.5 centimeters in these patients, or there were signs of inflammation without any fluctuation. Whereas in case of conservative treatment hot fomentation and antibiotics were recommended, some patients who received surgery or minimally invasive treatment also received prescriptions for antibiotics.  The antibiotics used were a combination of a beta-lactamase inhibitor, clavulanic acid, and a broad spectrum penicillin, namely amoxicillin, which could be used as an adjuvant or sole therapy. If there was no need for surgery to treat the abscess, the treatment was considered successful. Bio- statistical program (SPSS) version 2022 were used for the raw data description. Results: Total 100 female patients were considered and their aged from 20-40 years, lactating women were 42 while 58 women non-lactating. Group A consisted of 48 surgical patients who underwent incision and drainage, while Group B consisted of 52 patients who were treated conservatively. Ischemia, skin excoriation, wound sepsis, and postoperative septicemia were among the complications that were encountered during the postoperative period. Breast deformity, sinus formation, non-healing or closure, and organized abscess were diagnosed during the follow-up. There was no any mortality. Conclusion: Surgical drainage is the only option for treating breast abscesses, both large and small, as it significantly reduces morbidity.
Comparative Effectiveness and Complications of Surgical and Conservative Management in Breast Abscess Patients: A Prospective Analytical Study
Authors: Ayub Maria , Saqib Fajar , Iram Sadia , Shafique Amber , Tariq Farazia , Tariq Ribqa
Published: June 2024

Background: Mammary abscesses are infections that are enclosed without involving the surrounding tissues they are common with breast cancer patients through uncontrolled or poorly controlled mastitis. Hence, this work seeks to assess the management of surgical and conservative approaches for treating breast abscesses. Objective: The objective of the study was to ascertain the treatment methods used in management of breast abscesses and to determine the results and adverse outcomes of those that are applied. Methodology: A prospective analytical study was conducted in the Department of Surgery at Ghurki Trust & Teaching Hospital, Lahore, Pakistan, from February 2023 to March 2024. A total of 270 patients were initially enrolled, with 200 completing the 3-month follow-up. Patients were divided into two groups based on the treatment modality. Group I (Surgical Treatment) and Group II (Conservative/Minimally Invasive Treatment). SPSS version-20 was used to analyse results Patient groups were compared using the chi-squared test for categorical variables, for continuous variables, such as age, an independent samples t-test was utilized to compare the means between the two groups (p≤0.05) was considered. Results: Surgical treatment (Group I) demonstrated a significant reduction in reoperations and respiration compared to conservative treatments (Group II), where a notable percentage of patients (41.7%) needed further intervention. Notably, the rate of deformity due to scarring and contracture was higher in the conservative/minimally invasive group, affecting 30% of these patients, compared to 14.3% in the surgical group. Moreover, there was no carcinoma reported in group II in contrast with group I of the surgically operated patients 5% of them were found to have carcinoma. Conclusion: Surgical treatment for breast abscesses, particularly larger ones, offers more definitive resolution with fewer long-term complications compared to conservative management. Personalized treatment planning is essential to optimize patient outcomes and reduce morbidity.
TEACHERS’ STRATEGY USED IN TEACHING READING COMPREHENSION IN THE CLASSROOM
Authors: Christian Neni Purba  , Harpen Silitonga  , Karolina Sinulingga  , Nona Sony Manihuruk
Published: June 2024

Reading is one of the language skills which is very important to be learned by students. Through this activity, students can improve their own language and experience. The objectives of this research to find out the English teacher’s strategies in teaching reading comprehension and the advantages of using strategy. The research designed this study with qualitative method with the data from observation teaching learning process at SD HKBP Sidorame. The findings show that: the strategies commonly used by the English teacher in teaching reading comprehension at ten grade students of SMA HKBP Sidorame are question-answer relationship and discussion. The former eases the teacher in recognizing the students’ comprehension about the text, and helps the students develop an awareness of the multiple source of information in their reading. The later makes the students learn not only from the teacher but also from their fellow, and this strategy creates the active classroom atmosphere. In short, the mentioned strategies provide good contribution for both parties in the classroom: teacher and students.
AN ANALYSIS OF THE USE POSITIVE AND NEGATIVE POLITENESS BY NETIZENS ON ANIES BASWEDAN’S TWITTER ACCOUNT
Authors: Bertaria Sohnata Hutauruk  , Carolina Pakpahan  , Galina Sitinjak  , Tinadya Sinaga
Published: June 2024

Politeness is one of the phenomena found in daily communication. One of the studies of linguistics whose theory is pragmatic is called politeness. The objectives of this research to find out the politeness strategy and the percentage of the dominant type used by Indonesian netizents on Anies Baswedan Twitter. The research designed this study with qualitative method with the data from transcript of Indonesian netizents comment on Twitter. The findings show that: There are Bald on Record, Positive Politeness, Negativ Politeness, and Off Record. In twitter account there were 35 (33,65%) comments. In total, there are 2 (100%) Bald on Records, 13 (37,14%) Positive Politeness, and 9 (25,71%) Negative Politeness. The dominant type of Politeness Strategy used in Twitter accounts is Positive politeness. It takes 13 from 35 comments.
STRATEGI PENINGKATAN PENDIDIKAN KARAKTER DI LINGKUNGAN MADRASAH ALIYAH NEGERI PULAU TALIABU
Authors: Pardin
Published: June 2024

Thepurpose of this researh is to describ the managemeent of charactter formation programs at the State Islamic Senior High School of Pulau Taliabu. A qualiltative approch with a case study design was employed, conducted at MANi Pulau Taliabu. Data collection methods included observations, interviews, and document examinations, with data analysis involving summarization, presentation, and drawing conclusions. This study found that there are several distinct steps taken to strengthen character, such as observing and learning, cooperating, planning, executing the plan, reviewing it, and assessing how it can be improved. The school principal receives assistance from the team and coordinators. There are four aspects to implementing this plan: applying it in all aspects of the school, ensuring everyone believes in it, setting a real example, and communicating with parents. The school principal also oversees how the plan is implemented. Finally, they assess how well the plan is working, make changes if necessary, and discuss it with others..
ANALISIS KATEGORI, FUNGSI, DAN PERAN DALAM KALIMAT TUNGGAL BAHASA ACEH DIALEK PEUSANGAN
Authors: Rahil Helmi
Published: June 2024

Penelitian mengenai bahasa Aceh di berbagai bidang telah dilakukan, termasuk sastra dan struktur linguistik. Namun, belum ada penelitian yang secara khusus memeriksa Fungsi, Kategori, dan Peran dalam kalimat tunggal bahasa Aceh. Penelitian ini merupakan analisis sintaksis yang mempelajari unsur-unsur yang terdapat dalam sebuah kalimat, kata-kata kategori yang menduduki setiap fungsi dalam kalimat, dan makna semantisnya. Penelitian ini mengadopsi pendekatan deskriptif kualitatif dengan menggunakan berbagai sumber data, seperti data lisan, data tulisan, dan data buatan. Pengumpulan data lisan dilakukan melalui penerapan metode simak libat cakap. Sementara itu, data tulisan diperoleh dari beberapa buku dalam bahasa Aceh. Hasil analisis data disajikan dengan menggunakan metode distribusional. Dalam penelitian ini, ditemukan jenis-jenis peran dalam kalimat tunggal bahasa Aceh, antara lain peran agen, alat, asal, peruntung, lokatif, sasaran, tujuan, penanggap, penyerta, dan pengalam. Setiap peran memiliki kategori yang berbeda. Sebagai contoh, peran pelaku selalu diisi oleh kategori nomina, frasa nomina, pronomina, dan frasa pronomina. Kategori lain tidak dapat mengisi peran tersebut.
EDUKASI PENCEGAHAN STUNTING DI PEKON PAMPANGAN, LAMPUNG BARAT
Authors: Afriyani  , Damayanti Ervina , Islami Suryadi , Efendi M. Rifqi , Rusdi Mesa Sukmadani
Published: June 2024

Stunting adalah kondisi gagal tumbuh pada anak-anak yang ditandai dengan pertumbuhan dan perkembangan fisik yang terhambat. Walaupun hasil Studi Status Gizi Indonesia (SSGI) 2021 telah menunjukkan penurunan angka stunting nasional dari 27,7% pada tahun 2019 menjadi 24,4% pada tahun 2021. Namun, angka tersebut masih dikategorikan  tinggi menurut WHO (>20%). Penyuluhan ini bertujuan untuk memberikan edukasi kepada masyarakat khususnya kader Posyandu, ibu hamil, ibu menyusui dan ibu yang memiliki balita di Pekon Pampangan, Kecamtan Sekincau, Kabupaten Lampung Barat terhadap pencegahan stunting.
Metode pengabdian ini adalah metode pemberdayaan masyarakat partisipatif, yaitu metode yang menekankan keterlibatan masyarakat pada rangkaian kegiatan. Kegiatan penyuluhan pencegahan stunting berjalan dengan lancar dan sukses. Evaluasi menunjukkan adanya peningkatan pengetahuan peserta. Diharapkan bahwa penyuluhan ini akan meningkatkan kesadaran masyarakat mengenai tumbuh kembang anak, sehingga dapat mencegah terjadinya stunting dan menurunkan persentase stunting di Indonesia, terutama di Pekon Pampangan, Kecamatan Sekincau, Kabupaten Lampung Barat.
Addictive behavior of the younger generation: problems, solutions
Authors: Glebova Lyubov' Nikolaevna , Guseva Natal'ya Valer'evna
Published: June 2024

The article deals with the problem of the lack of a system of preparing subjects for the organization of psychological and pedagogical prevention of the younger generation in a general education institution, which will ensure the formation and development of a professionally competent personality of an employee of the modern field of education. The concept of addictive behavior of adolescents and the prevention of dependent behavior as a complex system and process, a unified concept and integration of efforts of the psychological and pedagogical community of educational institutions in modern socio-cultural conditions is considered. The problem of education and upbringing of the younger generation is very relevant today. This is due to the physical and psychological insecurity of a person due to the political, economic, and cultural realities of modern society. From these positions, it is the sphere of education, from our point of view, that should become a kind of foundation that guarantees respect for the rights of an individual in the field of his physical and psychological health. The authors studied the attitude of participants in the educational process of the Nizhny Novgorod region (Volga Federal District, Russia): teachers, administrative workers in the field of education, students and their legal representatives to the organization of psychological and pedagogical prevention of dependent behavior of adolescents in a general education institution, and the system of work of specialists in the prevention of dependent behavior of adolescents in a general education institution has been tested. The analysis showed that the key problem areas are: the creation of a system of value orientations of adolescents, the inculcation of generally accepted social norms; the creation of conditions for the prevention of coping strategies of adolescents, the formation of skills of responsible behavior, self-control and problem-solving planning skills; as well as the promotion of a healthy lifestyle among adolescents, which indicated the general need to increase the competence of employees in the indicated aspect. Based on the results of research and analysis of the experience of educational institutions, a system of prevention of dependent behavior of adolescents in a general education institution has been developed and described.
Sound as idea and matter: the problem of the nature of sound in the context of subject-object relations
Authors: Novikova Valeriya Sergeevna
Published: June 2024

The subject of the research is the conceptualization of sound as the embodiment of subject-object interaction, prioritizing one of the sides of the cultural and natural world. The article attempts, based on the analysis of two opposing discourses about sound – subject-oriented and object-oriented – to present the field of sound research as a space of continuous questioning, the image of which reflects any changes in ontological paradigms. The subject-oriented approach to sound is considered as a conceptual successor to the "linguistic turn" in the humanities. In this context, sound is understood as a noumenon, which is fundamentally inaccessible to direct comprehension and appears to us only in the form of a model of the sound already symbolically ordered and marked by a linguistic subject. The object-oriented approach is rooted in the "ontological turn", which received wide resonance in the 20th century, and, on the contrary, interprets sound as a force regardless of the subject's being, preceding any cultural and linguistic unfolding as a virtual sub-base.  Comparative analysis and contextual analysis are used as research methods. Comparative analysis is necessary to compare opposite approaches to the nature of sound, to identify similarities and differences that are not explicitly fixed. Contextual analysis clarifies key concepts and ideas within specific texts and the cultural and social conditions in which these texts were created. Having explicated the essence of both approaches and identified problematic aspects in each of them, the author suggests turning to the middle way, synthesizing materialistic and constructivist tendencies. This "materially symbolic" approach points to the illegality of the traditional explication of the concepts of subject and object, taken in a universalized and abstract way, and states the need to revise these terms through the prism of cultural and political determinants that unite knowledge and being, in particular from the standpoint of feminist and racial epistemologies. This approach focuses our attention on the bodily practices of producing knowledge and suggests taking into account cultural associations arising from the material life of sound. The main conclusion of the article is that we must critically rethink the concepts of the subject and object of sound research from the point of view of situational, historically conditioned material and social practices in order to get closer to understanding sound as such.
"Kantaje" ‒ translinguisme et transmédialité dans l’œuvre de Katalin Molnár
Authors: Györgyi Földes
Published: June 2024

Katalin Molnár is one of the most remarkable and interesting female artists of the Hungarian (neo-)avant-garde. She took an active part in the life of the neo-avant-garde émigré circles in Paris (and was an important contributor to the Magyar Műhely magazine), where her hybrid or transmedia genre, and sometimes hybrid language books, were published in the 1980s and 1990s. Her work, apart from one or two publications, has been rarely studied. In the present study, I will emphasize “transculturality” and related phenomena (translingualism and partly transmediality) in her work, as being extremely important for an understanding of the poetics she employs; in addition to other aspects not discussed in this paper, such as gender issues, career and network studies or her rich performance activity.
REGIONÁLIS TRANSZFORMÁCIÓ MINT POÉTIKA – TÖBBNYELVŰ EMLÉKEZET FORDÍTÁSBAN (BODOR ÁDÁM: VERHOVINA MADARAI)
Authors: Dánél Mónika
Published: June 2024

The article analyzes Ádám Bodor’s novel, The Birds of Verhovina, in the context of its translations. Utilizing “the aesthetic of ruins” (Hartmut Böhme), the novel encapsulates the cultural, social, ethnic, and linguistic diversity of a border region in their transformed (dis)appearance. As a result, the primary characteristic of the crafted multiethnic and multilingual narrative is one of metamorphosis. Furthermore, the historical evolution of a region transitions into an open, dynamic transnational poetics, where the Jewish and Hungarian cultural heritage and memory are compositionally present in their absence. The literary translations create a rich backdrop for the historical and multilingual layers within the novel. Through these translations, the mediated multilingual memory of a region circulates as an audible polyphonic “born translated memory” (Eneken Laanes).
Noval carrier accumulation reverse-conducting lateral insulated gate bipolar transistor
Authors: Duan Bao-Xing , Wang Jia-Sen , Tang Chun-Ping , Yang Yin-Tang ,   Key Laboratory of the Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi’an 710071, China
Published: June 2024

Reverse-conducting lateral insulated gate bipolar transistor (RC-LIGBT) with freewheeling diode integrated in the body by introducing n+ anode can realize the reverse conduction and optimize the turn-off characteristics of the device, which is a promising device in a power integrated circuit. In this work, a novel RC-LIGBT with electron-controlled gate (EG) and separated short-anode (SSA) is proposed and investigated by TCAD simulation, which can achieve low on-state voltage drop (Von) and low turn-off loss (Eoff) at the same time. The EG structure of p-n-n+-p (p+ region/n-type silicon region/n-type barrier layer/p+ region) is adopted, the gate electrode and anode electrode are connected by the EG structure. In the forward conduction state, a high-density electron accumulation layer is formed on the surface of the drift region by EG structure, which greatly reduces the Von of the device. At the same time, the use of the SSA structure can also optimize the Eoff of the device by forming an additional electron extraction channel. In addition, based on the EG structure, a low-doping p-drift can be combined with the SSA structure to simply achieve reverse-conduction and snapback-free characteristics. Furthermore, the EG structure and the SSA structure can complement each other. On the one hand, the high-density electron accumulation layer formed by EG structure compensates for the weakened conductance modulation effect caused by the SSA structure. On the other hand, the electron extraction channel of the SSA structure enables a large number of accumulated electrons to be removed quickly. The simulation results show that the proposed device has an excellent trade-off relationship between Von and Eoff, specifically, Von is 1.16V, which is 55% lower than that of SSA LIGBT, and Eoff is 0.099 mJ/cm2, which is 38.5% and 94.7% lower than that of SSA LIGBT and conventional LIGBT, respectively.
Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species
Authors: Li Xueyou , Bleisch William V. , Hu Wenqiang , Li Quan , Wang Hongjiao , Chen Zhongzheng , Bai Ru , Jiang Xuelong
Published: June 2024

Spatial and temporal associations between sympatric species underpin biotic interactions, structure ecological assemblages, and sustain ecosystem functioning and stability. However, the resilience of interspecific spatiotemporal associations to human activity remains poorly understood, particularly in mountain forests where anthropogenic impacts are often pervasive. Here we applied context-dependent Joint Species Distribution Models to a systematic camera-trap survey dataset from a global biodiversity hotspot in eastern Himalaya to understand how prominent human activities in mountain forests influence species associations within terrestrial mammal communities. We obtained 10,388 independent detections of 17 focal species (12 carnivores and five ungulates) from 322 stations over 43,163 camera days of effort. We identified a higher incidence of positive associations in habitats with higher levels of human modification (87 %) and human presence (83 %) compared to those located in habitats with lower human modification (64 %) and human presence (65 %) levels. We also detected a significant reduction of pairwise encounter time at increasing levels of human disturbance, corresponding to more frequent encounters between pairs of species. Our findings indicate that human activities can push mammals together into more frequent encounters and associations, which likely influences the coexistence and persistence of wildlife, with potential far-ranging ecological consequences.
The breath shape controls intonation of mouse vocalizations
Authors: MacDonald Alastair , Hebling Alina , Wei Xin Paul , Yackle Kevin
Published: June 2024

Intonation in speech is the control of vocal pitch to layer expressive meaning to communication, like increasing pitch to indicate a question. Also, stereotyped patterns of pitch are used to create distinct sounds with different denotations, like in tonal languages and, perhaps, the ten sounds in the murine lexicon. A basic tone is created by exhalation through a constricted laryngeal voice box, and it is thought that more complex utterances are produced solely by dynamic changes in laryngeal tension. But perhaps, the shifting pitch also results from altering the swiftness of exhalation. Consistent with the latter model, we describe that intonation in most vocalization types follows deviations in exhalation that appear to be generated by the re-activation of the cardinal breathing muscle for inspiration. We also show that the brainstem vocalization central pattern generator, the iRO, can create this breath pattern. Consequently, ectopic activation of the iRO not only induces phonation, but also the pitch patterns that compose most of the vocalizations in the murine lexicon. These results reveal a novel brainstem mechanism for intonation.
OVO Positively Regulates Essential Maternal Pathways by Binding Near the Transcriptional Start Sites in the Drosophila Female Germline
Authors: Benner Leif , Muron Savannah , Gomez Jillian G. , Oliver Brian
Published: June 2024

Differentiation of female germline stem cells into a mature oocyte includes the expression of RNAs and proteins that drive early embryonic development in
Drosophila
. We have little insight into what activates the expression of these maternal factors. One candidate is the zinc-finger protein OVO. OVO is required for female germline viability and has been shown to positively regulate its own expression, as well as a downstream target,
ovarian tumor
, by binding to the transcriptional start site (TSS). To find additional OVO targets in the female germline and further elucidate OVO’s role in oocyte development, we performed ChIP-seq to determine genome-wide OVO occupancy, as well as RNA-seq comparing hypomorphic and wild type rescue
ovo
alleles. OVO preferentially binds in close proximity to target TSSs genome-wide, is associated with open chromatin, transcriptionally active histone marks, and OVO-dependent expression. Motif enrichment analysis on OVO ChIP peaks identified a 5′-TAACNGT-3′ OVO DNA binding motif spatially enriched near TSSs. However, the OVO DNA binding motif does not exhibit precise motif spacing relative to the TSS characteristic of RNA Polymerase II complex binding core promoter elements. Integrated genomics analysis showed that 525 genes that are bound and increase in expression downstream of OVO are known to be essential maternally expressed genes. These include genes involved in anterior/posterior/germ plasm specification (
bcd, exu, swa, osk, nos, aub, pgc, gcl
), egg activation (
png, plu, gnu, wisp, C(3)g, mtrm
), translational regulation (
cup
,
orb
,
bru1, me31B
), and vitelline membrane formation (
fs(1)N
,
fs(1)M3
,
clos
). This suggests that OVO is a master transcriptional regulator of oocyte development and is responsible for the expression of structural components of the egg as well as maternally provided RNAs that are required for early embryonic development.
Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy
Authors: Zambo Boglarka , Edelweiss Evelina , Morlet Bastien , Negroni Luc , Pajkos Mátyás , Dosztányi Zsuzsanna , Ostergaard Soren , Trave Gilles , Laporte Jocelyn , Gogl Gergo
Published: June 2024

Truncation of the protein-protein interaction SH3 domain of the membrane remodeling Bridging Integrator 1 (BIN1, Amphiphysin 2) protein leads to centronuclear myopathy. Here, we assessed the impact of a set of naturally observed, previously uncharacterized BIN1 SH3 domain variants using conventional
in vitro
and cell-based assays monitoring the BIN1 interaction with dynamin 2 (DNM2) and identified potentially harmful ones that can be also tentatively connected to neuromuscular disorders. However, SH3 domains are typically promiscuous and it is expected that other, so-far unknown partners of BIN1 exist besides DNM2, that also participate in the development of centronuclear myopathy. In order to shed light on these other relevant interaction partners and to get a holistic picture of the pathomechanism behind BIN1 SH3 domain variants, we used affinity interactomics. We identified hundreds of new BIN1 interaction partners proteome-wide, among which many appear to participate in cell division, suggesting a critical role of BIN1 in the regulation of mitosis. Finally, we show that the identified BIN1 mutations indeed cause proteome-wide affinity perturbation, signifying the importance of employing unbiased affinity interactomic approaches.
Automating clinical assessments of memory deficits: Deep Learning based scoring of the Rey-Osterrieth Complex Figure
Authors: Langer Nicolas , Weber Maurice , Vieira Bruno Hebling , Strzelczyk Dawid , Wolf Lukas , Pedroni Andreas , Heitz Jonathan , Müller Stephan , Schultheiss Christoph , Tröndle Marius , Arango Lasprilla Juan Carlos , Rivera Diego , Scarpina Federica , Zhao Qianhua , Leuthold Rico , Wehrle Flavia , Jenni Oskar G. , Brugger Peter , Zaehle Tino , Lorenz Romy , Zhang Ce
Published: June 2024

Memory deficits are a hallmark of many different neurological and psychiatric conditions. The Rey-Osterrieth complex figure (ROCF) is the state–of-the-art assessment tool for neuropsychologists across the globe to assess the degree of non-verbal visual memory deterioration. To obtain a score, a trained clinician inspects a patient’s ROCF drawing and quantifies deviations from the original figure. This manual procedure is time-consuming, slow and scores vary depending on the clinician’s experience, motivation and tiredness.Here, we leverage novel deep learning architectures to automatize the rating of memory deficits. For this, we collected more than 20k hand-drawn ROCF drawings from patients with various neurological and psychiatric disorders as well as healthy participants. Unbiased ground truth ROCF scores were obtained from crowdsourced human intelligence. This dataset was used to train and evaluate a multi-head convolutional neural network.The model performs highly unbiased as it yielded predictions very close to the ground truth and the error was similarly distributed around zero. The neural network outperforms both online raters and clinicians. The scoring system can reliably identify and accurately score individual figure elements in previously unseen ROCF drawings, which facilitates explainability of the AI-scoring system. To ensure generalizability and clinical utility, the model performance was successfully replicated in a large independent prospective validation study that was pre-registered prior to data collection.Our AI-powered scoring system provides healthcare institutions worldwide with a digital tool to assess objectively, reliably and time-efficiently the performance in the ROCF test from hand-drawn images.
Balancing reaction-diffusion network for cell polarization pattern with stability and asymmetry
Authors: Chen Yixuan , Guan Guoye , Tang Lei-Han , Tang Chao
Published: June 2024

Cell polarization is a critical process that separates molecules into two distinct regions in prokaryotic and eukaryotic cells, guiding biological processes such as cell division and cell differentiation. Although several underlying antagonistic reaction-diffusion networks capable of setting up cell polarization have been identified experimentally and theoretically, our understanding of how to manipulate pattern stability and asymmetry remains incomplete, especially when only a subset of network components are known. Here we present numerical results to show that the polarized pattern of an antagonistic 2-node network collapses into a homogeneous state when subjected to single-sided self-regulation, single-sided additional regulation, or unequal system parameters. However, polarity can be restored through a combination of two modifications that have opposing effects. Additionally, spatially inhomogeneous parameters favoring respective domains stabilize their interface at designated locations. To connect our findings to cell polarity studies of the nematode
Caenorhabditis elegans
zygote, we reconstituted a 5-node network where a 4-node circuit with full mutual inhibitions between anterior and posterior is modified by a mutual activation in the anterior and an additional mutual inhibition between the anterior and the posterior. Once again, a generic set of kinetic parameters moves the interface towards either the anterior or posterior end, yet a polarized pattern can be stabilized through spatial tuning of one or more parameters coupled to intracellular or extracellular cues. A user-friendly software,
PolarSim
, is introduced to facilitate the exploration of networks with alternative node numbers, parameter values, and regulatory pathways.
Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism
Authors: Lin Susan , Gade Aravind R , Wang Hong-Gang , Niemeyer James E , Galante Allison , DiStefano Isabella , Towers Patrick , Nunez Jorge , Matsui Maiko , Schwartz Theodore H , Rajadhyaksha Anjali , Pitt Geoffrey S
Published: June 2024

Developmental and epileptic encephalopathies (DEEs), a class of devastating neurological disorders characterized by recurrent seizures and exacerbated by disruptions to excitatory/inhibitory balance in the brain, are commonly caused by mutations in ion channels. Disruption of, or variants in, FGF13 were implicated as causal for a set of DEEs, but the underlying mechanisms were clouded because FGF13 is expressed in both excitatory and inhibitory neurons, FGF13 undergoes extensive alternative splicing producing multiple isoforms with distinct functions, and the overall roles of FGF13 in neurons are incompletely cataloged. To overcome these challenges, we generated a set of novel cell-type-specific conditional knockout mice. Interneuron-targeted deletion of Fgf13 led to perinatal mortality associated with extensive seizures and impaired the hippocampal inhibitory/excitatory balance while excitatory neuron-targeted deletion of Fgf13 caused no detectable seizures and no survival deficits. While best studied as a voltage-gated sodium channel (Nav) regulator, we observed no effect of Fgf13 ablation in interneurons on Navs but rather a marked reduction in K+ channel currents. Re-expressing different Fgf13 splice isoforms could partially rescue deficits in interneuron excitability and restore K+ channel current amplitude. These results enhance our understanding of the molecular mechanisms that drive the pathogenesis of Fgf13-related seizures and expand our understanding of FGF13 functions in different neuron subsets.
Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism
Authors: Lin Susan , Gade Aravind R. , Wang Hong-Gang , Niemeyer James E. , Galante Allison , DiStefano Isabella , Towers Patrick , Nunez Jorge , Schwartz Theodore H. , Rajadhyaksha Anjali M. , Pitt Geoffrey S.
Published: June 2024

Developmental and Epileptic Encephalopathies (DEEs), a class of devastating neurological disorders characterized by recurrent seizures and exacerbated by disruptions to excitatory/inhibitory balance in the brain, are commonly caused by mutations in ion channels. Disruption of, or variants in,
FGF13
were implicated as causal for a set of DEEs, but the underlying mechanisms were clouded because
FGF13
is expressed in both excitatory and inhibitory neurons,
FGF13
undergoes extensive alternative splicing producing multiple isoforms with distinct functions, and the overall roles of FGF13 in neurons are incompletely cataloged. To overcome these challenges, we generated a set of novel cell type-specific conditional knockout mice. Interneuron-targeted deletion of
Fgf13
led to perinatal mortality associated with extensive seizures and impaired the hippocampal inhibitory/excitatory balance while excitatory neuron-targeted deletion of
Fgf13
caused no detectable seizures and no survival deficits. While best studied as a voltage-gated sodium channel (Na
v
) regulator, we observed no effect of
Fgf13
ablation in interneurons on Na
v
s but rather a marked reduction in K
+
channel currents. Re-expressing different
Fgf13
splice isoforms could partially rescue deficits in interneuron excitability and restore K
+
channel current amplitude. These results enhance our understanding of the molecular mechanisms that drive the pathogenesis of
Fgf13-
related seizures and expand our understanding of FGF13 functions in different neuron subsets.
Path for recovery: an ecological overview of the Jambato Harlequin Toad (Bufonidae: Atelopus ignescens) in its last known locality, Angamarca Valley, Ecuador
Authors: Vega-Yánez Mateo A. , Quezada-Riera Amanda B. , Rios-Touma Blanca , Vizcaíno-Barba María del Carmen , Millingalli William , Ganzino Orlando , Coloma Luis A. , Tapia Elicio E. , Dupérré Nadine , Páez-Vacas Mónica , Parra-Puente David , Franco-Mena Daniela , Gavilanes Gabriela , Salazar-Valenzuela David , Valle Carlos A. , Guayasamin Juan M.
Published: June 2024

The Jambato Harlequin toad (Atelopus ignescens), a formerly abundant species in the Andes of Ecuador, faced a dramatic population decline in the 1980s, with its last recorded sighting in 1988. The species was considered Extinct by the IUCN until 2016, when a fortuitous discovery of one Jambato by a local boy reignited hope. In this study, we present findings from an investigation conducted in the Angamarca parish, focusing on distribution, abundance, habitat preferences, ecology, disease susceptibility, and dietary habits of the species. In one year we identified 71 individuals at different stages of development in various habitats, with a significant presence in agricultural mosaic areas and locations near water sources used for crop irrigation, demonstrating the persistence of the species in a complex landscape, with considerable human intervention. The dietary analysis based on fecal samples indicated a diverse prey selection, primarily comprising arthropods such as Acari, Coleoptera, and ants. Amphibian declines have been associated with diseases and climate change; notably, our study confirmed the presence of the pathogen Batrachochytrium dendrobatidis (Bd), but, surprisingly, none of the infected Jambatos displayed visible signs of illness. When analyzing climatic patterns, we found that there are climatic differences between historical localities and Angamarca; the temporal analysis also exposes a generalized warming trend. Finally, in collaboration with the local community, we developed a series of management recommendations for terrestrial and aquatic environments occupied by the Jambato.