bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential expression of sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1 in cancers of the breast.
Authors: Mamoor Shahan
Published: November 2021

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1, SVEP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SVEP1 was also differentially expressed in the brain metastases of patients with metastatic breast cancer. SVEP1 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SVEP1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. SVEP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Makalah Manajemen Sumber Daya Manusia
Authors: Istiqamah Nur Afwa
Published: November 2021

Makalah terkait Manajemen Sumber Daya Manusia
Questions on notice to Falinksi Inquiry
Authors: Murray Cameron
Published: November 2021

A response to questions on notice for Australia's 2021 Inquiry into housing affordability and supply in Australia. First, is a negative relationship between change in housing stock and real price from OECD data (1990-2015) solid evidence? Second, what do developers actually say about how they manage undeveloped land? Third, what questions should be asked to developers in this Inquiry.
Seeing what I did (not): Cerebral and behavioral effects of agency and perspective on episodic memory re-activation
Authors: Jainta Benjamin , Siestrup Sophie , El-Sourani Nadiya , Trempler Ima , Wurm Moritz , Werning Markus , Cheng Sen , Schubotz Ricarda
Published: November 2021

Intuitively, we assume that we remember episodes better when we actively participated in them and were not mere observers. Independently of this, we can recall episodes from either the first-person perspective (1pp) or the third-person perspective (3pp). In this functional magnetic resonance imaging (fMRI) study, we tested whether agency and perspective modulate neural activity during memory retrieval and subsequently enhance memory performance. Subjects encoded a set of different episodes by either imitating or only observing videos that showed short toy stories. A week later, we conducted fMRI and cued episodic retrieval by presenting the original videos, or slightly modified versions thereof, from 1pp or from 3pp. The hippocampal formation responded more strongly to episodic mismatches in previously self-performed vs. only observed actions. In a post-fMRI memory test a history of self-performance did not improve behavioral memory performance. However, modified videos were often (falsely) accepted as showing truly experienced episodes when: (i) they were already presented in this modified version during fMRI or (ii) they were presented in their original form during fMRI but from 3pp. Together, our findings demonstrate that self-performance and self-perspective modulate the strength of a memory trace in different ways. Even when memory performance remains the same for different agentive states, the brain is capable of detecting mismatching information. Re-experiencing the latter impairs memory performance as well as retrieving encoded episodes from 3pp.
RESUME BUKU "AGAMA DAN BAYANG - BAYANG ETIS SYAIKH YUSUF AL - MAKSSARI" BAB IV
Authors: Idris Musfira
Published: November 2021

catatan terkait dengan resume buku "Agama dan Bayang - bayang etis
Body Representation in Anorexia Nervosa
Authors: Keizer Anouk , Engel Manja
Published: November 2021

Anorexia nervosa (AN) is an eating disorder that mainly affects young women. One of the most striking symptoms of this disorder is the distorted experience of body size and shape. Patients are by definition underweight, but experience and perceive their body as bigger than it in reality is. This body representation disturbance has fascinated scientists for many decades, leading to a rich and diverse body of literature on this topic. Research shows that AN patients do not only think that their body is bigger than reality, and visually perceive it as such, but that other sensory modalities also play an important role in oversized body experiences. Patients for example have an altered (enlarged) size perception of tactile stimuli, and move their body as if it is larger than it actually is. Moreover, patients with AN appear to process and integrate multisensory information differently than healthy individuals, especially in relation to body size. This leads to the conclusion that the representation of the size of the body in the brain is enlarged. This conclusion has important implications for the treatment of body representation disturbances in AN. Traditionally treatment of AN is very cognitive in nature, it is possible however that changed cognitions with respect to body size experiences do not lead to actual changes in metric representations of body size stored in the brain. Recently a few studies have been published in which a multisensory approach in treatment of body representation disturbance in AN has been found to be effective in treating this symptom of AN.
Differential expression of talin 2 in cancers of the breast.
Authors: Mamoor Shahan
Published: November 2021

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding talin 2, TLN2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TLN2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TLN2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. TLN2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Cognitive Flexibility Moderates the Efficacy of a Visuospatial Intervention Following Exposure to Analog Trauma
Authors: Hemi Alla , Sopp Roxanne , Perel Ariel , Holmes Emily A , Levy-Gigi Einat
Published: November 2021

Objective: Intrusive memories are the hallmark feature of Post-Traumatic-Stress-Disorder (PTSD). Recent studies have found that a visuospatial intervention after viewing traumatic films reduces intrusive memories in healthy individuals. However, many individuals still exhibit high levels of symptoms following such an intervention, warranting continued investigation into specific characteristics moderating intervention effect. One such candidate is cognitive flexibility, defined as the ability to update behavior in accordance with contextual demands. The present study aimed at examining the interactive effect of cognitive flexibility and a visuospatial intervention on intrusive memories, predicting that higher flexibility would be linked to stronger intervention effects. Method: Sixty participants (Mage = 29.07, SD = 4.23) completed a performance-based paradigm evaluating cognitive flexibility, watched traumatic films, and were allocated to either an intervention or control group. Intrusions were assessed by means of laboratory and ambulatory assessment, and the Impact of Events Scale – Revised (IES-R). Results: Participants in the intervention group experienced fewer laboratory intrusions than the control group. However, this effect was moderated by cognitive flexibility: Whereas individuals with below-average cognitive flexibility did not benefit from the intervention, it was significantly beneficial for individuals with average and above-average cognitive flexibility. No group differences emerged in the number of ambulatory intrusions or IES-R scores. However, cognitive flexibility was negatively correlated with IES-R scores across both groups. Conclusions: These results highlight the significant role of cognitive flexibility in intrusion development, both in general and as a moderator of a visuospatial interventions. Future studies should investigate effects’ generalizability to clinical samples.
Black Protests in the US, 1994-2010
Authors: Oliver Pamela Elaine , Lim Chaeyoon , Matthews Morgan , Hanna Alex
Published: November 2021

Using novel data, we provide the first panoramic view of US Black movement protest events as reported in US newswires between 1994 and 2010 and put our quantitative data into dialog with qualitative accounts. Struggles during these years presaged the Black Lives protest waves of 2014-2016 and 2020. Protests increased after the 1995 Million Man March into 2001, but dropped abruptly after the 9/11 attacks. Collective action increased again at the end of the 2000s. Protests in response to police violence and other criminal legal issues were major arenas of struggle and news coverage. Also common were issues of national identity including celebrations of Black history and Black solidarity, protests about Confederate symbols, and protests about White hate groups and hate crimes. While Black people protested about a wide variety of issues, newswires focused disproportionately on incidents of police violence and perceived threats of Black violence. There is substantial continuity in issues, organizations, and activism between this earlier period and the Black Lives Movement of 2014-2020. Content warning: parts of this article describe incidents of police violence.This is a preprint of an article forthcoming in Sociological Science.
pplication of deep learning model in recognition of growth stages of Cucumis melo L. in greenhouse
Authors:   National Center for Technological Progress, Dang Hoang Anh Tuan , Nguyen Minh Thang ,   Vietnam - Korea Institute of Science and Technology
Published: November 2021

Despite the increasing application of deep learning (DL) models in various socioeconomics such as financial analysis and forecast, intelligent transport, self-driving, disease diagnosis, the effective use of this technology to support agricultural cultivation is still limited. This paper introduces the implementation of the lightest and state-of-the-art YOLOv5 architecture for automatic recognising of important growth stages of Cucumis meloL. from the camera images collected in the greenhouse. This image identification initiative achieved an average accuracy of 96% F1-score in the identification of the five growth stages of Cucumis melo L. using a limited set of training and testing data (total 2,818 images of Cucumis melo L.). These preliminary results lead to the conclusion that the YOLOv5 object detection and classification model is a truly lightweight and promising DL solution after the adoption of the transfer learning technique. Moreover, the YOLOv5 model can execute good performance on edge devices which may open up a new approach in different object detection and classification in real-time directly from a smartphone, Jetson Nano, IP camera...
Preliminary investigation of the presence of PFOS and PFOA in water and sediment in Cau river
Authors:   School of Environmental Science and Technology, Hanoi University of Science and Technology, Tran Hoai Le ,   Faculty of Environmental Engineering, National University of Civil Engineering, Vu Duc Thao ,   School of Environmental Science and Technology, Hanoi University of Science and Technology, Huynh Trung Hai ,   School of Environmental Science and Technology, Hanoi University of Science and Technology, Hoang Thi Lien ,   Analytical Laboratory for Environment, Dioxin and Toxics; Northern Center for Environmental Monitoring
Published: November 2021

Perfluoro-octane sulfonate (PFOS) and Perfluoro-octanoic acid (PFOA) are recognised as emerging environmental pollutants because of their high persistence in various environmental matrices and toxic effects on humans and animals. The objectives of this study were to preliminarily investigate the occurrence of PFOS and PFOA in the water and sediment of the Cau river in Thai Nguyen city. The concentration of PFOS and PFOA in water ranged from <LOQ-0.67 ng/l and 0.05-8.11 ng/l; 1.19-4.73 ng/g, and 0.17-1.78 ng/g in sediment, respectively. The highest total concentrations of PFOS and PFOAwere recorded in the areas that directly received wastewater from domestic and industrial activities. The water-sediment distribution coefficient (Kd) was relatively different for PFOS and PFOA, with Kd ranged from 20.51-72.83 l/g and 1.21-20.31 l/g for PFOS and PFOA, respectively. This result suggested the distribution of PFOS and PFOA between water and sediment, in which PFOS will preferentially deposit in the sediment, and PFOA will tend to distribute in the liquid phase of the aquatic environment.
Experimental study on essential anise star oil purification in vacuum batch distillation
Authors:   School of Chemical Engineering, Hanoi University of Science and Technology, Nguyen Thi Thao , Do Xuan Truong ,   School of Chemical Engineering, Hanoi University of Science and Technology
Published: November 2021

Vietnam is one of the world’s largest annual anise harvest countries. However, products from anise are mainly in the form of dried anise fruit and crude star anise essential oil with low economic value. The main component of the star anise essential oil is trans-anethole which needs to be purified to produce higher-value products. This study focused on building an experimental system for purifying star anise essential oil by a batch distillation column working at vacuum pressure. The products obtained during the purification process were analysed by gas chromatography-mass spectrometry (GC-MS). Analytical results were used to evaluate the ability to separate volatile impurities in the crude star anise essential oil. Results showed that the bottom temperature of the tower below 150oC, corresponding to a vacuum pressure of less than 0.1 bar, can reduce the thermal decomposition of essential oils. The volatile components, such as α-pinene, β-phellandrene, limonene, and linalool, were thoroughly separated at the top of the tower. The purified star anise essential oil was from the bottom of the distillation and had the anethole composition of over 88% of mass fraction (wt.%). Anethole recovery efficiency was 98.5 and 88.8% at a pressure of 0.1 and 0.08 bar, respectively. The bottom product can have a higher anethole composition if increasing the column height, the reflux ratio, and decreasing the pressure and the quality of impurities removed at the top is increased.The experimental results are helpful for the calculation, design, manufacture, and operation of an industrial-scale essential oil purification system.
„I nie tylko w powiastkach drzemie ta historia” – „Młyn Bałtaragisa” Kazysa Boruty: literatura jako medium pamięci
Authors: Niemojewski Marcin
Published: November 2021

“Whitehorn’s Windmill” is considered to be the most outstanding work of KazysBoruta and one of the most important Lithuanian novels of the 20th century. Thebook was written during World War II when the Lithuanian state became theobject of aggression of two totalitarian powers and lost independence for a longtime, and it has grown from the writer’s anxiety about the fate of his country and the persistence of Lithuanian identity. Hence, Boruta reached for the richresources of the native folklore, to evoke the mythologized image of theLithuanian village, which in Lithuanian literature has the rank of chronotope,and at the same time, it is an important component of Lithuanian imaginationabout the sources of national culture. The story, the meaning and functions of the“Whitehorn’s Windmill,” its genesis and post-war fate, its literary and non-literarycontexts, as well as the history of its reception, allow us to interpret the workfrom the perspective of reflection on literature as a medium of cultural memory.
Przeszłość i teraźniejszość staroprawosławia na Ukrainie
Authors: Pastuszewski Stefan
Published: November 2021

The small (6–7 thousand) diaspora of Old Orthodox Russians in Ukraine, rooted for over 350 years, after the events of 2014, began to be subject to processes of alienation. The amended religious law began to stigmatize Russians by imposing the obligation to specify in the statutes and names of their organizations and institutions that they are Russian, that is, related to the “aggressor state”. There were local attacks on religious buildings of Old Orthodox Russians. After a few years, the situation stabilized.
Intercultural Communication: Context and Meaning : учебное пособие / С.С. Грецкая. – М.: «КДУ», «Университетская книга», 2021. – 162 с.
Authors: Грецкая С.С.
Published: November 2021

«Intercultural Communication: Context and Meaning» – учебное пособие, адресованное студентам, обучающимся по программам бакалавриата, специалитета и магистратуры. Пособие разработано в соответствии с учебной программой дисциплины «Практикум по межкультурной коммуникации», соответствует актуальным требованиям ФГОС 3++ по направлению подго-товки «Лингвистика» (45.03.02), а также ОС МГУ для реализуемых основных профессиональных образовательных программ высшего образования по соответствующему направлению подготовки. Учебное пособие «Intercultural Communication: Context and Meaning» спроектировано в соответствии с принципами ориентированного на создание проблемной научно-образовательной среды компетентностного подхода к профессиональной подготовке студентов, обучающихся по направлению «Лингвистика», профиль «Теория и практика межкультурной коммуникации». Вместе с тем материалы могут быть использованы в процессе межкультурной подготовки широкого круга студентов-гуманитариев с целью изучения влияния контекста на внутри- и межкультурную коммуникацию и проблем оптимизации межкультурного взаимодействия в современном мире.
Review on Status of Organic Farming
Authors: Zewide Isreal
Published: November 2021

Organic agriculture started much more recently in thousands of years ago, Agriculture almost equal share of the farming systems of crop production and characterizes the key issues of Ethiopian economy. The quality of organic resources and their fertilizer equivalence are the main criteria to be judged for effective utilization of the organic resources for soil fertility improvement and promotion of agricultural products both in quantity and quality.Organic agriculture is production system that sustains the health of soils, ecosystems and people. The evaluation of organic matter in soils depends on type and nature of organic source. Organic agriculture in the extent to which African farmers certified yields (more than 50% higher than local yield averages). The export main products produced are cotton, sesame and coffee, followed by cocoa, dried fruits, frozen fruit/pulp, fresh mainly tropical fruit and spices. Ethiopia is famous as the origin of coffee and is the largest producer in Africa. Forest coffee has the advantage that it originates from an organic and shaded production area - a quality increasingly important for coffee drinkers worldwide coffee cultivation systems, superior quality and organic in nature. Certified-organic farmers will generally require a higher price to compensate for the costs of inspection, certification and the major source of foreign exchange and thus account more than half of the value of total export. Total number of 12 forest coffee cooperatives in remote areas of southwestern Ethiopia were certified according to Fairtrade, organic (EU standard) and Utz Certified standards. The common understanding of agricultural production in all types of organic agriculture is managing the production capacity of an agro-ecosystem. Pesticides and fertilizers are damaging human health and polluting the surrounding environment and thus violating the sustainability of ecosystem.
Dietary Therapy for Celiac Disease: Suggestions for the Practical Application of the Diet Offered by Gastronomy
Authors: Pal Mahendra , Molnár Judit
Published: November 2021

Celiac disease is an inherited disease. In this case, the protein found in the wheat, barley, rye, and oats (α-gliadin - the alcohol-soluble component of gluten) damages the small intestinal mucosa of the body. As a result of the damage, absorption is impaired. The only way to treat it is through diet, so it is imperative to completely avoid the gluten-containing products. These must be replaced by gluten-free products. The primary purpose of the manuscript is to formulate dietary recommendations for patients with celiac disease. In addition, dishes are prepared and presented that can be an active part of the diet (fried chicken with potato garnish; fruit smoothie with coconut drink; chicken with mixed vegetable salad; fried eggs with fried vegetables and extruded gluten-free cornbread). These foods can be used effectively as part of a gluten-free diet. We hope to provide useful information for the scientific community. In addition, we can contribute to the protection of their health.
A Few Words About a West Nile Virus
Authors: Franjić Siniša
Published: November 2021

West Nile Virus (WNV) can cause neurological disease and death in people. WNV is commonly found in Africa, Europe, the Middle East, North America and West Asia. WNV is maintained in nature in a cycle involving transmission between birds and mosquitoes. Humans, horses and other mammals can be infected. On web page of World Health Organisation [1], can be read how approximately 80% of people who are infected will not show any symptoms. West Nile virus is mainly transmitted to people through the bites of infected mosquitoes. The virus can cause severe disease and death in horses. Vaccines are available for use in horses but not yet available for people. Birds are the natural hosts of West Nile virus.
Prevalence of Hypertension and Associated Factors among Bank Workers in Harar Town, Eastern Ethiopia 2018
Authors: Teklehaymanot Zewde Gosaye
Published: November 2021

Background: Hypertension clinically defined as a blood pressure of 140/90 mmHg or more on at least two readings on separated time. It is one of the most prevalent non communicable diseases and the most important preventable risk factor for premature death worldwide, due to heart disease and stroke. It is the most important modifiable risk factor for coronary heart disease, stroke, congestive heart failure, end stage renal disease and peripheral vascular diseases Objective: To assess the prevalence of hypertension and its associated factors among bank workers in Harar town, Eastern Ethiopia 2018 Methods and material: Institutions based cross sectional study was conducted on 149 Bank workers in 6 governmental and 19 private banks which were found in Harar Town. Sample was allocated proportionately and study participant was selected by simple random sampling. Collected and checked data were entered in to Epi Data software version 3.02 and exported and analyzed using SPSS version 21. Descriptive statistics were used to determine prevalence such as frequency, percentage, mean and ratio. Both Bivariate and multiple logistic regressions were used to observe the association between the outcome variable and associated factors. P value less than 0.2 in Bivariate analysis was transferred to multivariate analysis and P value less than or equal to 0.05 was considered as level of statistically significance. Result: The prevalence of hypertension on this study was 27.5 %. Among study participant 6(4%) had diagnosed with hypertension and only 3 (2%) had on treatment and follow- up. 26(17.4%) bank workers BMI Was obsessed. In multivariable logistic regression analysis Age, Sedentary life style and BMI of bank workers had significant association with hypertension Conclusion and recommendation: The prevalence of Hypertension in the study was 27.5% Age, Sedentary life style and BMI (Obesity) in this study was positively associated with higher odds of having hypertension. Regular blood monitoring, conducting physical exercise and reduction of Alcohol consumption and street Treatment care and follow-up strategy need to be maintained.
The Biophysical Modeling of the Sleep Regulation in the Human Organism
Authors: Vincze Janos , Vincze-Tiszay Gabriella
Published: November 2021

A seventy-year-old human spends approx. twenty years, or one-third of their life, asleep. During sleep, their connection with the outside world is more or less lost, but in the meantime they experience exciting dreams that are difficult for rational thinking to grasp. Analysis of EEG recordings revealed that sleep can be divided into two sharply separated states: one is the so-called slow wave sleep; the other is the so-called paradoxical sleep (REM), e.g. characterized by strong eyeball movement. The slow sleep period can be divided into 4 periods based on the EEGs, and these follow each other in a well-defined order, then comes the paradoxical sleep and the whole thing is repeated; during a full sleep of approx. 4–6 times. The duration of paradox sleep depends on the individual, but it lasts for approx. 6–15 minutes. Compared to the literature, one of the significances of this article is also that we wrote a mathematical model of the sleep. This model also allows us to characterize different forms of particular sleep.
Estimation of CYP3A4*1B single nucleotide polymorphism using target-assembled in-situ detection by synthetic DNA-mounted excimers
Authors: M Gbaj Abdul , A Sadawe Inass , H Meiqal Nisreen , M Bensaber Salah , R Hamid Abdulhamid , Salem Maamar Massaud , Hermann Anton
Published: November 2021

CYP3A4*1B is a single nucleotide polymorphism of CYP3A4 and is associated with prostate cancer which exhibits higher nifedipine oxidase activity in liver. This research provides details of the effects of structural variation and medium effects for the recently reported split-oligonucleotide (tandem) probe system for excimers-based fluorescence detection of DNA. In this approach the detection system is split at a molecular level into signal-silent components, which must be assembled correctly into a specific 3-dimensional structure to ensure close proximity of the excimer partners and the consequent excimer fluorescence emission on excitation. The model system consists of two 11-mer oligonucleotides, complementary to adjacent sites of a 22-mer DNA target. Each oligonucleotide probeis equipped with functions able to form an excimer on correct, contiguous hybridization. The extremely rigorous structural demands for excimer formation and emission required careful structural design of partners for excimer formation, which are here described. This study demonstrates that the excimer formed emitted at ~480 nm with alarge Stokes shift (~130 - 140 nm).
Recalibration of the Antimicrobial MIC
Authors: Amsterdam Daniel
Published: November 2021

In 2009, the World health organization (WHO) referred to the problem of antibiotics and antibiotic resistance stating, “Antibiotic Resistance – one of the three greatest threats to human health.” In 2019 (i.e., just as the COVID-19 pandemic was evolving), more than 2.8 million antibiotic-resistant infections were identified in the United States, resulting in more than 35,000 deaths (CDC 2019). The initial laboratory assay which demonstrated the activity of an antibacterial compound was performed by Alexander Fleming. He showed that an extract from the mold, Penicillium rubens, could inhibit the growth of several species of Gram-positive bacteria – but not Gram-negative bacteria that were cross-streaked on agar against the diffused Penicillium compound.
Malnutrition: Already exist and is being overlooked?
Authors: Gökçe Şule , Aslan Aslı , Koç Feyza
Published: November 2021

Background: Malnutrition is defined as deficiency and or imbalance of nutrients and energy and may produce a negative effect on the growth, maintenance, and specific functions of the body. This study purposed to determine the nutritional situation, to define the presence of malnutrition, to detect the deficiencies of micronutrients of the children admitted to a pediatric tertiary hospital. Methods: A retrospective, cross‑sectional, single unit-based study in pediatric patients admitted to the pediatric wards for differential diagnosis or treatment was conducted between November 2017 and December 2019. The anthropometric measurements were figured out on hospital admission of all pediatric patients. The pediatric patients diagnosed with malnutrition were assessed to detect their nutritional status/feeding habits and to identify any associated factors. Results: A total of 1206 children were hospitalized with an acute illness diagnosis and/or treatment during the study period. One hundred fifteen patients were noted to have malnutrition; acute malnutrition (wasting) (weight for height z-score < - 2 SDS) (n=51/115, 44.3%) and chronic malnutrition (stunted) (height-for-age < −2 SDS) was detected in 64/115 (55.7%) patients; the prevalence of wasting, and stunting was 4.2% and 5.3%, respectively. Conclusions: Our study suggests that it should be performed an assessment of nutritional status/ history and anthropometric measurements every admission to the hospital in order to provide healthy growth development in childhood, particularly under 2 of age and interventions should be strengthened for general child health.
Correlation of Uric Acid with Oxidative Stress and Endothelial Dysfunction in Type 2 Diabetes Mellitus
Authors: Palem Siva Prasad
Published: November 2021

Objective: To evaluate the correlation of uric acid with oxidative stress and endothelial dysfunction in type 2 diabetic subjects.Material and Methods: The study included 120 subjects, among when 60 were type 2 diabetes subjects and the remaining 60 were age and gender matched healthy controls. The biochemical parameters, blood glucose, lipid profile, uric acid and homocysteine, were measured by standard kits in an autoanalyzer. Oxidative stress was evaluated by measuring malondialdehyde (MDA) and total antioxidant power by manual methods such as thio-barbituric acid reactive substances and ferric reducing ability of plasma (FRAP). Endothelial dysfunction was assessed by measuring nitric oxide (NO) by the kinetic cadmium method.Results: A significant elevation of triglycerides, low density lipoprotein (LDL), and MDA were observed in the type 2 diabetes mellitus patients while FRAP and NO were significantly reduced compared to the healthy controls. In addition, the uric acid levels had a highly significant correlation with FRAP (r=0.212, p-value=0.020), and moderately significant correlation with triglycerides (r=0.173, p-value=0.057) and homocysteine (r=0.178, p-value=0.051). Uric acid was negatively correlated with MDA and positively correlated with NO, but not statistically significant.Conclusion: Our findings suggest that uric acid may have antioxidant properties since it had a significant positive correlation with FRAP.
The effectiveness of moxifloxacin in the treatment of community-acquired pneumonia
Authors: Dmytriiev Dmytro , Nazarchuk Oleksandr , Babina Yuliana
Published: November 2021

The article presents the results of domestic and international studies of the use of the fourth-generation fluoroquinolone moxifloxacin in the treatment of commu-nity-acquired pneumonia and pneumonia caused by SARS-CoV-2. Analysis of the clinical use of moxifloxacin in the treatment of complications of the respiratory tract infec-tions indicates its high efficiency and bioavailability, a low risk of resistance, which makes it possible to recommend it for widespread use in the work of a practicing doctor. Ge-neric drug Maxicin (Yuria-Pharm), available as a 20 mg/ml concentrate in a 20 ml vial, can significantly reduce the cost of treatment and optimize infusion therapy by choosing both volume and solvent.
The effectiveness of Dekasan for prevention of postoperative complications after major bone surgeries
Authors: Kalashnikov A , Kalashnikov O , Stavinskiy Yu , Litun Yu , Khodakovsky Yu
Published: November 2021

Antiseptic drug “Decasan” due to its bactericidal, fungicidal, viricidal and sporicidal action is a highly effective medicine for the prevention of postoperative complications in an orthopedic and trauma hospital. Its use can significantly reduce the frequency of complications, and thus reduces the need for systemic antibiotics and slows down the develop-ment of antibiotic resistance.
Processing the results of space observation of the processed areas of Karaganda
Authors:   Karaganda Technical University, Karaganda, Kazakhstan. E-mail: halidok_09_95@mail.ru, Alimzhanova A. , Kadylbekova Kh. ,   Karaganda Technical University, Karaganda, Kazakhstan. E-mail: kadylbekova.halida@mail.ru
Published: November 2021

The article is devoted to the development of a method for tracking deformation in the underworked territories of Karaganda based on the data processed by radar images from the ENVISAT satellite. The article provides an overview of the use of modern radar satellite systems. The step-by-step search of archival data on the territory of Karaganda in the Eoli-sa program is described. The processing of radar images from the ENVISAT satellite for the period from 2003 to 2010 in the SARscape module of the ENVI software package is described in detail. Based on the processed data, graphs of dynamic processes were compiled. The analysis of the results of interferometric processing of radar data is performed. Traditional and modern methods of tracking the deformation of underworked territories are also analyzed.
How to Integrate STEM Education in The Indonesian Curriculum? A Systematic Review
Authors:   Universitas Muhammadiyah Kudus, Central Java, Indonesia. E-mail: janu@umkudus.ac.id, Arlinwibowo J. , Retnawati H. ,   Mathematics and Science Faculty, Universitas Negeri Yogyakarta, Indonesia. E-mail: heri_retnawati@uny.ac.id, Kartowagiran B. ,   Prost Graduate Program, Universitas Negeri Yogyakarta, Indonesia. E-mail: kartowagiran@uny.ac.id
Published: November 2021

STEM education has received a lot of attention, including in Indonesia, because it is considered capable of preparing competitive students in the 21st century. However, the implementation of STEM learning is constrained because there are no standard guidelines according to the curriculum 2013 (education curriculum in Indonesia). Therefore, the aim of this study is to find an integration formula for STEM learning and the curriculum 2013 based on the synthesis of various literature to find a formula for implementing STEM learning in accordance with the curriculum 2013. This study is a systematic review. The data sources in this research are 46 selected literatures and relevant to the research objectives published between 1996 and 2020. The data sources are literature published in ISBN books, government documents, and journals. The data collected from the literature were analyzed with a thematic model starting with data introduction, initial coding, compiling code within a theme, analyzing themes, naming themes, and relating findings to research questions. The research resulted in a learning step that combines EDP in STEM, the scientific approach in the 2013 curriculum, and project learning steps. The merger produces a guideline for implementing STEM learning in the 2013 curriculum starting from problem identification, making problem-solving designs, design realization, testing and studying product deficiencies, improving products, drawing conclusions, and communicating the findings of the learning process.
Processing and production of pellets from poor-grade manganese-containing raw materials
Authors:   Satbayev University, Institute of Metallurgy and Ore Beneficiation, Kazakhstan. E-mail: a.tastanova@stud.satbayev.university, Tastanova A. , Abdykirova G. ,   Satbayev University, Institute of Metallurgy and Ore Beneficiation, Kazakhstan. E-mail: g.abdykirova@satbayev.university, Temirova S. ,   Satbayev University, Institute of Metallurgy and Ore Beneficiation, Kazakhstan. E-mail: s.temirova@satbayev.university, Biryukova A. ,   Satbayev University, Institute of Metallurgy and Ore Beneficiation, Kazakhstan. E-mail: a.biryukova@satbayev.university
Published: November 2021

there is a review of current researches in the processing of poor-grade manganese raw materials. The variety of manganese minerals caused by the valent state of metal in compounds is demonstrated. Different processing methods for manganese-containing mineral and technogenic raw materials are considered. The process of extraction of manganese from ferruginous manganese ore using reduction roasting and magnetic separation, beneficiation technology of poor-grade manganese ore to improve the ratio of Mn/Fe; processes of beneficiation and sintering of fine ferruginous manganese ore with low manganese content; production of agglomerate from the concentrate of manganese poor-grade ore to produce ferrosilicon manganese are described. Results of the authors researches intended to obtain concentrate from manganese-containing sludge and to produce hardened pellets suitable for melting into ferromanganese on its basis using a new component of the binder are presented.
Beneficiation of fine chromite slurry at Donskoy Mining and Beneficiation Plant JSC on concentration tables to produce hard chromite pellets
Authors:   Institute of Metallurgy and Ore Beneficiation JSC, Satbayev University Almaty, Kazakhstan. Email: i/bondarenko@imio.kz, Bondarenko I.V. , Kuldeyev E.I. ,   Institute of Metallurgy and Ore Beneficiation JSC, Satbayev University Almaty, Kazakhstan. Email:kuldeev_erzhan@mail.ru
Published: November 2021

Processing industrial products and technogenic waste is an important task in the mining and metallurgical industry. In Kazakhstan, the processing of chrome ore from the Kempirsay group of deposits has produced more than 15 million tonnes of slurry tailings containing up to 30 wt% chrome oxide. The best results in the world for the processing of fine chromium raw materials are shown by Turkish enterprises with the use of the separation of slurries by size classes and beneficiation on concentration tables. The authors conducted researches for beneficiation of chrome slurry from Dubersay tailings pond (Kazakhstan) with the use of similar technological methods that enabled to obtain concentrates with chrome oxide content of 51 wt% and increasing the yield of beneficiated fine-graded chrome concentrates by 14% as compared with the existing beneficiation process. Strong chromium pellets with a crushing resistance of over 5000 N/pellet were produced from the rich chromium concentrates with the use of the ferrofluxing iron-calcium-silica binder technology by roasting the composition consisting of rich chromium concentrate, ferrous diatomite, and intermediate products and wastes of the chromium industry.
Organizational and managerial conditions for creating a health-saving environment of an educational organization
Authors:   Candidate of Pedagogical Sciences, Acting Associate Professor of Kh. Dosmukhamedov Atyrau University. Email: aigul_bekbol@mail.ru, Uteshkalieva A. , Kumarova Z. ,   2nd year Master's student OP 7M01301 -Management in Education Kh. Dosmukhamedov Atyrau university. Email address: kumarova94@inbox.ru
Published: November 2021

This article examines the organizational and managerial conditions for creating a health-preserving environment of an educational organization, presents a model of a health-preserving environment that contributes to increasing the levels of activity, positive cognitive motivation, interest, organization, independence of students of the educational space. Authors highlighted that it is necessary to properly organize students' individual educational and cognitive activities that correspond to individual capabilities and abilities, as well as the conditions of the educational environment.
Formation of teachers of the initial stage of education - readiness for innovation
Authors:   Candidate of Pedagogical Sciences, assoc. Professor Atyrau University named after Kh. Dosmukhamedov. Email: aigul_bekbol@mail.ru, Uteshkalieva A. , Saginova B. ,   Graduate student of Atyrau University named after Kh. Dosmukhamedov, specialty 7M01301 "Management in education". Email: batima1997@bk.ru
Published: November 2021

This article examines the readiness and formation of teachers of primary education - innovative activity. The relevance of this topic lies in the search and application of innovative technologies in primary schools, where the main task of teachers is to quickly adapt to modern innovations and the ongoing changes in updated education. The XXI century is called the century of high or digital technologies, and therefore creative, active, fast-learning and inquisitive people are in demand in any industry. The modern system of updated education develops children's research and cognitive structure of activity. In this regard, adjustments are made to the educational program in almost every country to develop students' abilities, based on research and cognitive activity, where one of the first steps is primary school.
Ways of organizing the educational process in elementary school based on the project-research form of educational activity
Authors:   Candidate of Pedagogical Sciences, Acting Associate Professor of Atyrau University named afterKh. Dosmukhamedov. E-mail: aigul_bekbol@mail.ru, Uteshkaliyeva А. , Galymova N. ,   Graduate student of Atyrau University named after Kh. Dosmukhamedova 7M01301 "Management in education". E-mail: nurii-94@list.ru
Published: November 2021

This article examines the ways of organizing the educational process in primary school on the basis of the project-research form of educational activity. The relevance of this topic lies in the search and application of the design and research form of educational activity in primary school, where the main task of teachers is to quickly adapt to modern projects and the ongoing changes in updated learning. The XXI century is called the century of high or digital technologies. Creative, active, fast-learning and inquisitive people are in demand in any industry. The modern system of updated education develops children's research and cognitive structure of activity. Therefore, in the educational program, in almost every country, adjustments are made for the development of students' abilities, based on research and cognitive activity, where one of the first steps is primary school.
On methods of modifying natural minerals
Authors:   Institute of Metallurgy and Ore Beneficiation, Satbayev University, Republic of Kazakhstan. E-mail: bagdaulet_k@satbayev.university, Kenzhaliyev B. , Surkova T. ,   Institute of Metallurgy and Ore Beneficiation, Satbayev University, Republic of Kazakhstan. E-mail: tu-surkova@mail.ru, Berkinbayeva A. ,   Institute of Metallurgy and Ore Beneficiation, Satbayev University, Republic of Kazakhstan. E-mail: ainur_kbk@mail.ru, Dossymbayeva Z. ,   Institute of Metallurgy and Ore Beneficiation, Satbayev University, Republic of Kazakhstan. E-mail: zdos@mail.ru, Yesimova D. ,   Institute of Metallurgy and Ore Beneficiation, Satbayev University, Republic of Kazakhstan. E-mail: dina-28@inbox.ru, Abdikerim B. ,   Institute of Metallurgy and Ore Beneficiation, Satbayev University, Republic of Kazakhstan. E-mail: abdikerim-2030@mail.ru
Published: November 2021

Recently, more and more attention is paid to the ecological safety of the republic due to the increased threat of environmental pollution by radionuclides, particularly by uranium, while the processing of uranium-containing raw materials generates a significant amount of liquid industrial waste. The main waste disposal method is a sorption, which requires the use of inexpensive sorbents. Such sorbents can be obtained on the basis of domestic natural raw materials. The significant disadvantages of natural sorbents are a low sorption capacity, which can be increased by developing effective and relatively cheap methods for their modification. The absence of the methods of modification is a limiting factor for the widespread using of natural sorbents for environmental purposes. Variants of modification of natural aluminosilicate and coal-mineral raw materials of Kazakhstan by physical and chemical methods are considered. The chemical methods include the modification with a mixture of tributylphostat and di-2-ethylhexylphosphoric acid in kerosene to obtain "solid-phase extractants", a mixture of phosphoric acid and polyacrylamide, and the synthesis of organominerals. The possibility of using technogenic raw materials as a modifying reagent has been studied. Zeolite of the previously unexplored Kosmurun deposit and shungite of the Koksu deposit were selected for research, and slags of phosphorus production were selected as a technogenic raw materials. Their physical and chemical properties have been studied.
Extraterritorial application of the right to life on the high sea . Commentary to the Views adopted by the Human Rights Committee of 27 January 2021, A.S., D.I., O.I. and G.D. against Italy, Communication No. 3042/2017
Authors: Pacholski Bartosz
Published: November 2021

The subject matter of this commentary, which instigates the Views of the Human Rights Committee of 27 January 2021, is the protection of one of the fundamental human rights – the right to life. The Committee, as an authority appointed to oversee compliance with the International Covenant on Civil and Political Rights, had to decide on the issue of Italy’s responsibility for failing to provide assistance to a boat in distress, even if the area in which the vessel was located was not within the territory of this state and other acts of international law attribute the responsibility for executing the rescue operation to a third country. According to the Committee’s views, which applied extraterritorial approach to the protection of the right to life, whenever states have the opportunity to take action for the protection of human rights they should do everything possible in a given situation to help people in need.
Vibration characteristics of rotating functionally graded porous beams reinforced by graphene platelets
Authors: Binh Chu Thanh , Quoc Tran Huu , Huan Duong Thanh , Hien Ho Thi
Published: November 2021

This work aims to study the vibration characteristics of the rotating functionally graded porous beam reinforced by graphene platelets. The beam is mounted and rotated around a hub with a constant velocity. The material properties vary along the thickness direction with two types of porosity distributions and two dispersion patterns of graphene platelet. The equations of motion based on the Timoshenko beam theory are obtained and solved using the Chebyshev-Ritz method. The effects of the parameters such as hub radius, rotating speed, weight fraction, porosity distribution, porosity coefficient, and dispersion model are presented. The present method results are also compared with numerical results available in the literature.
Rayleigh waves in compressible orthotropic half-space overlaid by a thin un-coaxial orthotropic layer
Authors: Hue Trinh Thi Thanh , Phuong Phan Thi Thu , Anh Pham Hong
Published: November 2021

The problem of Rayleigh waves in compressible orthotropic elastic half-space overlaid by a thin elastic layer of which principal material axes are coincident have been researched by many scientists. However, the problem with the conditions that the half-space and the layer have only one common principal material axis that perpendicular to the layer while the remains are not identical has not gotten enough attention. This paper presents a traditional approach to obtain an approximate secular equation by approximately replacing the thin layer by effective boundary conditions of third-order. The wave then is considered as a Rayleigh wave propagating in an orthotropic half-space, without coating, subjected to the effective boundary conditions. This explicit approximate secular equation is potentially useful in non-damage assessment studies.