bluuebunny/crossref_metadata_2025 huggingface dataset:
Originalidad en la 1ra de las 6 Propuestas Obtenidas para Rediseñar Una Vivienda de Interés Social
Authors: Álvarez Martínez José Erick , Rendón Hidalgo Vicente , Elizalde Domínguez Continente
Published: July 2024

En este documento se hace la descripción de la originalidad contenida en la 1ra de las 6 propuestas que fueron previstas para rediseñar académicamente una vivienda de interés social. Siendo el resultado del análisis documental efectuado al anteproyecto ejecutivo de esta propuesta, que permitió identificar las singularidades de la clientela. Observando su trascendencia en ciertas etapas del proceso proyectual, detallando cualitativamente sus alcances y cuantitativamente determinado sus valores. Factores que sientan el precedente para hacer aprecio de todo el trabajo que hay detrás de los planos arquitectónicos.
Raytracing en la Palma de tu Mano: Desafíos y Oportunidades en el Desarrollo de Videojuegos Móviles
Authors: Cabello-Carranza Alejandro Yael , Domínguez Jiménez Ismael
Published: July 2024

En la última década las aplicaciones y videojuegos del ámbito móvil han tenido una evolución significativa en su visualización y manejo de elementos gráficos, destacándose el raytracing como una técnica revolucionaria para representar luz y sombras en entornos 3D, ofreciendo un alto realismo ahora en dispositivos móviles. Este artículo examina cómo la evolución de motores gráficos como Unity y Unreal, junto con API's gráficas como Vulkan y OpenGL, ha facilitado la implementación del raytracing. Estas tecnologías permiten a los desarrolladores manipular gráficos 3D de manera más precisa, integrando el raytracing para experiencias visuales inmersivas. No obstante, la adopción del raytracing en la visualización móvil enfrenta varios desafíos, especialmente en la optimización y consumo de energía de los dispositivos móviles. En este sentido, se exploran estos desafíos y analizan estrategias implementadas por la industria para superarlos, se abordan ejemplos de implementaciones exitosas, herramientas de optimización y posibles avances futuros para mejorar las capacidades del raytracing en dispositivos móviles.
Desafíos y Oportunidades en la Integración de Sistemas de Información Médico – Administrativo: Un estudio Cualitativo en el Hospital de la Región Soconusco
Authors: López Escobar Carlos Alberto , Hernández Castillo Jehiely Belem , Cabrera Gómez Teresa del Carmen , Matuz Cruz Manuel de Jesús
Published: July 2024

En el contexto de mejorar continuamente los servicios de salud, el hospital de la Región Soconusco, emprendió un estudio para evaluar la eficiencia operativa de sus sistemas independientes en áreas claves como Urgencias, Quirófano y Consulta Externa, entre otros. El estudio cualitativo, realizado en el pasado, implicó la recopilación y análisis de datos a través de entrevistas semiestructuradas y grupos focales como médicos, enfermeras y personal administrativo. Los módulos individuales del hospital incluyen Trabajo Social, Archivo Clínico, Estadística, Almacén, Farmacia y más, fueron examinados para identificar errores operativos y oportunidades de mejora, con el fin de preparar la integración de estos en un único sistema de información médica administrativa. El análisis de las entrevistas reveló tanto la aceptación de los sistemas existentes como los desafíos técnicos enfrentados por los usuarios, destacando la necesidad de una plataforma integrada que pueda mejorar la coordinación y el acceso a la información médica. Los hallazgos subrayaron que, aunque los módulos funcionan a niveles satisfactorios de manera independiente, su integración podría potenciar significativamente la eficiencia operativa y la calidad del cuidado al paciente.La finalidad de este estudio fue proporcionar una base empírica para el desarrollo de un sistema integral que unifique las operaciones administrativas y clínicas del hospital, asegurando que la tecnología responda adecuadamente a las necesidades del personal médico y administrativo. Este enfoque proyecta la integración de sistemas buscando facilitar una práctica médica más segura y eficiente, alineada con los estándares modernos de la gestión de salud
Uso de Redes Neuronales en el Análisis de Frotis de Células Sanguíneas Periféricas: una Revisión Sistemática de la Literatura
Authors: Perez Guillen Luis Francisco , Matuz Cruz Manuel de Jesús , Arana Llanes Julia Yazmín , Guzmán Albores Jorge Martín , Peralta González María Soledad , González Cárdenas Noé
Published: July 2024

La automatización del reconocimiento y clasificación de las células sanguíneas facilita a los médicos el diagnóstico de diversas enfermedades de la sangre al analizar sus características. Diversas investigaciones han desarrollado diversos algoritmos que emplean métodos de aprendizaje profundo, específicamente Redes Neuronales, para clasificar los diversos tipos de glóbulos sanguíneos. Es por ello, que este trabajo de investigación, se presenta una revisión sistemática sobre el tema de Uso de Redes Neuronales en el Análisis de Frotis de Células Sanguíneas Periféricas.
Análisis de la reprobación en época de pandemia en el primer semestre de la carrera de Ingeniería en Gestión empresarial del Instituto Tecnológico de Zacatepec
Authors: Contreras Rojas Maria del Socorro , Palacios Contreras María Lidia , Velázquez Vázquez Rogaciano , López Medina Brenda Selene
Published: July 2024

Este análisis surge como una necesidad de conocer la causa raíz de la reprobación del ITZ para cumplir con uno de los criterios del CACECA (Consejo de Acreditación de Ciencias Administrativas, Contables y Afines) y continuar con la acreditación del programa educativo de Ingeniería en Gestión Empresarial, ya que en promedio por generación a nivel institucional tiene en enero-junio 2019 un promedio de reprobación del 29.3%. Y se pide tener un promedio menor al 10% de reprobación
Carotid paraglioma: a modern approach to diagnosis and treatment
Authors: Yarikov A. , Makeeva O. , Kalinkin А. , Dalibaldyan V. , Lukyanchikov V. , Fraerman A. , Mukhin A. , Aivaziyan S. , Tsybusov S.
Published: July 2024

The scientific paper presents a literature update on carotid paraganglioma, a rare tumor. The initial manifestation of a carotid body tumor is a painless lump in the neck. The paper gives data on its prevalence, classification, clinical presentations, the applicability of various diagnostic methods, as well аs on the efficiency of treatment for this disease and emerging complications. Ultrasound, multispiral computed tomography, magnetic resonance imaging, and direct angiography are usually used for the diagnosis of the disease. Complete surgical excision of the carotid body tumor is the method of choice, as the results of radiation and chemotherapy are unsatisfactory.
An integrated approach to cervical cancer prevention
Authors: Klinyshkova Т. , Frolova N.
Published: July 2024

Cervical cancer (CC) is the fourth most common cancer among women in the world. In the Russian Federation, the incidence of cervical cancer is in second position in the structure of genital cancers. The WHO Global Strategy to Accelerate the Elimination of CC as a Public Health Problem recommends an integrated approach to prevention and control of CC that combines vaccination, screening and treatment. A review and analysis of modern data on this problem over the past decade is presented. Scaling up HPV vaccination, increasing the level of cervical screening and coverage of the female population, developed post-screening management and timely treatment of precancer will reduce the incidence and mortality associated with cervical cancer.
ASSOCIATIONS OF DEPRESSION WITH PARAMETERS OF ATTITUDE TO MEDICAL CARE IN OPEN URBAN POPULATION, GENDER ASPECT
Authors: Kayumova M. , Bessonova M. , Gafarov V. , Gakova E. , Akimov A. , Lebedev E. , Novoselov A. , Petelina T. , Akimova E.
Published: July 2024

Objective. To establish associations of a high level of depression with certain parameters of attitudes towards medical care in women in an open urban population. Subjects and methods. A cross-sectional epidemiological study was conducted on a representative sample of women aged 25–64, formed from the electoral lists of citizens of the city of Tyumen in the amount of 1000 people, the response was 70.3%. The levels of depression and the attitude of the population to medical care were determined using the standard WHO MONICA-MOPSY questionnaire. Results. About a third of women in the open urban population showed the presence of depression, over four age decades of life, a tendency was established for a decrease in the prevalence of D from its low level to an average and further to a high level, a tendency to an increase in the prevalence of D from the fourth to the sixth decade of life was noted. Half of the women in the open population, regardless of age, only with severe pain in the region of the heart would go to the doctor and trust specialized studies more, and only a third part would go to the doctor if there was any pain in the region of the heart and trust the examination of the doctor. One-fifth of the population was more guided by their well-being, and not by the doctor's opinion. In the presence of a high level of depression in women of the open population, associations with the parameters of attitude to medical care were established and the minimum activity in the prevention and treatment of CVD was determined. Conclusion. Thus, the results of the study obtained on an open urban population, which identified the most vulnerable categories of women with a high level of depression, can serve as a scientific basis for the formation of comprehensive preventive programs to reduce the risks of developing CVD in female populations of medium urbanized cities of Western Siberia.
A clinical case of an individual approach in the treatment of a patient with tuberculosis of the lungs and bronchus in combination with mycobacteriosis and Crohn's disease
Authors: Chumovatov N. , Polushkina E. , Chernyh N. , Sivokozov I. , Komissarova O.
Published: July 2024

In the Russian Federation, there is an increase in patients with pulmonary tuberculosis in combination with comorbid pathologies, including Crohn's disease. There is also a tendency to increase the combination of pulmonary tuberculosis and non-tuberculosis mycobacteriosis, which makes it difficult to select adequate therapy and reduces the effectiveness of treatment. Bronchial tuberculosis is one of the complications of the tuberculosis process and often masks the onset of this disease. In this connection, the diagnosis of the tuberculosis process in the bronchi is difficult. A young patient with a history of Crohn's disease was diagnosed with pulmonary and bronchial tuberculosis in combination with non-tuberculosis mycobacteriosis. Upon admission, the presence of intoxication syndrome and bacterial excretion in sputum was noted. Taking into account the presence of comorbid pathology, anti-tuberculosis therapy was carried out according to an individual chemotherapy regimen with predominant parenteral administration of drugs. Against the background of the ongoing treatment, the patient noted the addition of a coronavirus infection with the development of viral pneumonia. Thanks to an individual approach in the treatment of the tuberculosis process in combination with non-tuberculosis mycobacteriosis and the presence of Crohn's disease, it was possible to achieve the relief of intoxication syndrome, the cessation of bacterial excretion in sputum and positive X-ray and endoscopic dynamics. This clinical example demonstrates the high effectiveness of an integrated approach in the treatment of tuberculosis in the presence of concomitant diseases. Due to the early endoscopic diagnosis, the patient revealed a tuberculous process in the bronchi. Given the presence of these diseases, complex chemotherapy was aimed at treating tuberculosis and mycobacteriosis simultaneously. Taking into account mainly parenteral administration of chemotherapy drugs, there was no exacerbation of Crohn's disease. The addition of coronavirus infection with the development of viral pneumonia did not affect the course of the tuberculosis process and non-tuberculosis mycobacteriosis.
EDUCAÇÃO FÍSICA E PRÁTICAS CORPORAIS: Discussões Emergentes
Authors: Almeida Junior Admir Soares de , Scaglia Alcides José , Pereira Álex Sousa , Silva Alysson dos Anjos , Silva Angélica de Souza , Fuentes Antonio Rodríguez , Mendes Ariana Marjory , Magalhães Júnior Carlos Augusto , Ramos Danilo da Silva , Santos Diego Ramires Silva , Prodócimo Elaine , Pinto Evelyn Garci , Arruda Gabriel Augusto Vianna , Sousa Galdino Rodrigues de , Figueiredo Juliana de Paula , Leonardo Lucas , Almeida Felipe Quintão de , Godoy Luís Bruno de , Silva Luís Felipe Nogueira , Souza Marcos Junio Graciano de , Silva Matheus Marques da , Mesquita Pâmela do Nascimento , Fernandes Poliana Barreto , Miguel Rebeca Signorelli , Colpas Ricardo Ducatti , Costa Roberto Rocha , Vieira Rubens Antonio Gurgel , Andrade Rubian Diego , Krahenbuhl Tathyane , Duek Viviane Preichardt , Correia Walter Roberto
Published: July 2024

"Educação Física e Práticas Corporais: Discussões Emergentes" explora a Educação Física crítica, propondo práticas inovadoras e inclusivas. Com capítulos que abordam desde jogos, TICs, didática, questões étnico-raciais e outros, o livro desafia educadores(as) a repensar suas metodologias. Celebrando a diversidade e a transformação social, esta obra coletiva inspira uma pedagogia dinâmica e reflexiva. É um convite para mergulhar em novas perspectivas, promovendo uma educação que vai além do convencional, comprometida com a equidade e justiça social.
The Memetic Form of Bret Harte's Ah Sin: From the American West to The Way We Live Now
Authors: Valdez Jessica R.
Published: July 2024

Abstract: This essay argues that Ah Sin—a character in American poet Bret Harte's satirical poem, "Plain Language from Truthful James"—became a meme used in racialized thinking across the nineteenth-century Anglophone world. Variations of the Ah Sin character appeared in forms ranging from newspapers and the burlesque to Anthony Trollope's novel, The Way We Live Now . Trollope's The Way We Live Now deploys the meme to critique the workings of a media landscape prone to oversimplification and exclusion. By contrast, the novel renarrativizes Ah Sin by invoking the poem's contexts of the American West. However, instead of Harte's Chinese gold miner, Trollope creates an imaginary Chinese emperor, thereby reflecting the complicated geopolitics of British and American attitudes toward Chinese migration and the Qing empire.
Remifentanil as an anesthetic agent in children
Authors: Maria I Dalamagka
Published: July 2024

Remifentanil hydrochloride is an ultra-short-acting opioid that undergoes rapid metabolism by tissue and plasma esterases. Remifentanil is increasingly used as an adjuvant to general anaesthesia in neonates undergoing surgery because of its favourable haemodynamic and respiratory effects compared with other agents. The pharmacokinetic profile of remifentanil appears well suited for use in the sedation of children for short, day case procedures and remifentanil has been demonstrated to be an attractive drug for this purpose. Owing to higher clearances, younger children will require higher infusion rates of remifentanil than older children and adults to achieve equivalent plasma concentrations. Propofol and remifentanil appear to be gaining popularity for short procedures in children. Together they provide sedation, anxiolysis and analgesia, possibly best provided by separate continuous infusions. They also promote haemodynamic stability, minimal respiratory depression, with a rapid recovery profile. The use of remifentanil in neonates and young infants is increasing despite the difficulties in obtaining high standard objective evidence in this age group. Remifentanil’s pharmacokinetic and pharmacodynamic profile in this age group is similar to that of older children, which may have several theoretical advantages. Reports of a rapid development of µ-receptor tolerance with remifentanil are in conflict; activity at δ-opioid receptors may contribute. Remifentanil produce a fall in blood pressure and cardiac index, mainly as a result of a fall in heart rate. Although atropine is able to reduce the fall in heart rate, is not able to prevent completely the reduction in cardiac index. Remifentanil has been described as a titratable opioid. It has been reported to be ideally suited to the sedation of selected neurosurgical patients who require frequent neurological examinations. It may also provide suitable analgesia based sedation in mechanically ventilated children postoperatively.
Cybersecurity strategies in fintech: safeguarding financial data and assets
Authors: Omolara Patricia Olaiya  , Temitayo Oluwadamilola Adesoga  , Adefisayo Ojo  , Oluwabusola Dorcas Olagunju  , Olajumoke Oluwagbemisola Ajayi  , Yusuf Olalekan Adebayo
Published: July 2024

The financial technology (fintech) sector has witnessed remarkable expansion in recent years, fundamentally reshaping the landscape of financial services delivery and consumption. This growth is driven by new technologies such as mobile banking, digital wallets, blockchain and artificial intelligence Keenan the risk for fintech has increased. As pioneers in the use of technology to enhance financial transactions, Fintech has become an attractive target for cybercriminals looking to exploit weaknesses in digital infrastructure. The evolving nature and sophistication of cyber threats, including phishing attacks, ransomware, data breaches, and insider threats, pose significant risks to the integrity and security of financial data and assets. This paper aims to provide a comprehensive review of cybersecurity strategies implemented within the fintech industry to safeguard against these threats. It examines the current landscape of cyber risks facing fintech firms, highlighting the multifaceted challenges posed by malicious actors and technological vulnerabilities. Moreover, the paper evaluates the effectiveness of various cybersecurity measures adopted by fintech companies, such as encryption protocols, multi-factor authentication, AI-driven threat detection, and blockchain technology. Furthermore, the review discusses emerging trends and technologies poised to bolster cybersecurity in the fintech sector. These include advancements in quantum-resistant encryption, zero-trust architecture, regulatory compliance frameworks (e.g., GDPR, PCI DSS), and proactive incident response strategies. By exploring these innovative approaches, the paper seeks to illuminate proactive measures that can mitigate cyber risks and enhance resilience in fintech operations.
An Examination of Copyrightability and Creativity in AI-generated Works: Focusing on the Instrumentality of Generative AI
Authors: Kang Hyeonho , Han Euitae , Jeong Jaeseok ,   Korea Copyright Commission
Published: July 2024

With burgeoning interest in generative artificial intelligence (AI), the legal status of outputs generated by such technologies, henceforth referred to as AI-generated works, has become a pivotal issue. This manuscript examines the characteristics of prevalent generative AI systems and the intricate process behind AI-generated works. It underscores the imperative for a copyright discourse surrounding AI-generated works, in light of the aims and perspectives of extant copyright laws, and the policy objectives that underpin industrial advancement. The discourse posits the necessity to view generative AI as an innovative instrument for human creativity, substantiating the ‘instrumentality’ of generative AI with a multitude of evidences. Additionally, considering the uniqueness of AI-generated works compared to traditional creative works, the manuscript proposes criteria for acknowledging the copyrightability of AI-generated works, focusing on ‘Predictability of Generative Works’ to demonstrate the instrumentality of generative AI and ‘Specificity of Prompts’ to assess the creativity of AI-generated works. By presenting these new perspectives on AI-generated works, the paper aims to promote the development of culture, related industries, and the generative AI industry.
Pengabdian Donor Darah di Klinik dan Apotek Ali Maksum “Satukan Kepedulian Menuju Keberkahan dengan Berbagi Kebahagiaan”
Authors: Yogananda Amrina Amalia , Fa'izah Nurul , Hasanudin Muhammad Nurul
Published: July 2024

Darah merupakan salah satu komponen utama tubuh. Peran sebagai alat transportasi dalam tubuh menjadikan darah sebagai salah satu faktor penting dalam kehidupan. Ketidakseimbangan antara jumlah pasokan darah dengan permintaan darah di beberapa Unit Transfusi Darah (UTD) sering terjadi sehingga menyebabkan kelangkaan darah di UTD. Berdasarkan situasi tersebut, dosen dan mahasiswa program studi Farmasi Universitas Nahdlatul Ulama Yogyakarta bersama dengan Klinik Pratama BKM Ali Maksum dan Apotek Ali Maksum tergerak untuk mengadakan pengabdian donor darah di lingkungan klinik dan apotek Ali Maksum. Kegiatan donor darah bekerjasama dengan Palang Merah Indonesia (PMI) Kabupaten Sleman. Tujuan pengabdian donor darah untuk menumbuhkan rasa kepedulian sosial terhadap sesama manusia dan untuk memenuhi kebutuhan stok kantong darah di PMI Kabupaten Sleman. Tahap pelaksanaan pengabdian dibagi 4, yaitu (1) tahap koordinasi dan persiapan, (2) sosialisasi, (3) pendaftaran peserta, (4) pelaksanaan donor darah dan edukasi masyarakat. Pengabdian donor darah dilaksanakan pada 2 Desember 2022 dengan jumlah peserta sebanyak 57 orang dan mendapatkan 33 kantong darah. Karakteristik peserta donor yang memenuhi syarat adalah sebanyak 52% peserta berjenis kelamin laki-laki, sebanyak 42% peserta memiliki golongan darah O, sebanyak 21% peserta berusia 17 – 25 tahun, dan seluruh peserta (100%) memiliki rhesus positif. Secara keseluruhan, acara berjalan lancar dengan terkumpulnya 33 kantong darah dan masyarakat mendapatkan pengetahuan mengenai manfaat donor darah.
Pendampingan Praktikum IPA Sederhana Bagi Guru-Guru SMP di Kecamatan Amanatun Selatan Kabupaten Timor Tengah Selatan
Authors: Nau Getrudis Wilhelmina , Missa Hildegardis , Ndukang Sardina
Published: July 2024

Paradigma pembelajaran abad 21 mengharuskan guru harus lebih kreatif dan inovatif dalam merancang pembelajaran yang membuat peserta didik melek sains. Salah satu cara adalah melalui pembelajaran berbasis praktikum. Kenyataannya keterbatasan sarana dan prasarana praktikum di beberapa SMP di Kecamatan Amanatun Selatan  menuntut guru harus lebih kreatif merancang praktikum-praktikum sederhana, namun guru-guru belum sepenuhnya memahami dengan baik hakikat praktikum dalam pembelajaran serta kurang terampil merancang praktikum IPA berbahan sederhana yang mudah ditemukan. Kegiatan ini bertujuan memberikan pemahaman serta memberikan pendampingan agar guru menjadi terampil merancang praktikum IPA berbahan sederhan. Metode yang digunakan adalah sosialisasi, demonstrasi dan bimbingan teknis/pendampingan kepada mitra. Hasil kegiatan ini adalah pemahaman guru-guru SMP di Kecamatan Amanatun Selatan menjadi terbuka dan lebih berinovasi mengembangkan macam-macam praktikum dengan alat dan bahan sederhana yang mudah ditemukan.
Edukasi Pemeriksaan Golongan Darah Bagi Siswa Sekolah Menengah EBC Fatuquero Gleno Distrito Ermera Timor Leste
Authors: Pogo Fransiskus Jordin , Laka Religius Karo , Nau Getrudis Wilhelmina , Missa Hildegardis , Santos Americo Dos
Published: July 2024

Transfusi darah merupakan suatu tindakan pemberian darah dari donor ke resipien. Dalam kondisi tertentu transfusi darah dapat sangat bermanfaat menyelamatkan nyawa manusia. Oleh karena itu penting bagi seseorang mengetahui golongan darahnya. Namun permasalahan yang dialami masyarakat khususnya siswa sekolah menengah EBC Fatuquero Gleno Timor Leste adalah belum adanya pemahaman mengenai golongan darah manusia dan pentingnya pemeriksaan golongan darah. Hal ini menjadi dasar kegiatan ini dilakukan dengan tujuan memberikan edukasi menyeluruh kepada siswa sekolah menengah EBC Fatuquero mengenai golongan darah dan pentingnya mengetahui golongan darah masing-masing. Metode yang digunakan adalah sosialisasi, demonstrasi dan uji golongan darah secara langsung dengan metode slide. Hasilnya adalah seluruh siswa memahami tentang tipa-tipe golongan darah manusia dan cara melakukan pemeriksaaan golongan darah seseorang serta mengetahui golongan darah mereka masing-masing.
Pelatihan Pembuatan Curriculum Vitae yang Kreatif untuk Alumni Mahasiswa Program Studi Pendidikan Bahasa Indonesia, FKIP Universitas Malikussaleh
Authors: Emilda Emilda , Maulidawati Maulidawati , Rahayu Ririn , Safriandi Safriandi , Nuraiza Nuraiza
Published: July 2024

Alumni sebagai lulusan perguruan tinggi banyak hal yang harus dipersiapkan untuk mendapatkan pekerjaan salah satunya adalah Curriculum Vitae (CV). Curriculum Vitae yang menarik dapat meningkatkan kesempatan seorang pelamar kerja untuk mendapatkan pekerjaan impiannya. Permasalahan mitra adalah belum mampu menyusun Curriculum Vitae dengan benar dan menarik. Tujuan dari kegiatan pengabdian ini adalah peserta mampu membuat Curriculum Vitae ketika melamar pekerjaan. Metode yang digunakan dalam pengabdiaan ini berbentuk pelatihan, agar peserta dapat praktik secara langsung setelah mendapatkan materi. Pelatihan penulisan CV yang kreatif dan menarik ini dilaksanakan Gedung FKIP Universitas malikussaleh yang diikuti sebanyak 6 orang alumni program studi Pendidikan Bahasa Indonesia, FKIP Universitas Malikussaleh. Kegiatan dilaksanakan selama 1 hari dengan metode ceramah, diskusi dan kerja mandiri berupa pengisian pada format CV yang kreatif. tingkat kehadiran peserta adalah 100% dimana semua peserta hadir pada saat pelatihan dan rata-rata peserta sudah menguasai aplikasi Microsoft word sebagai media untuk pengisian format CV yang telah di tentukan. Peserta antusias dalam mengikuti pelatihan dimana banyak diskusi oleh peserta terhadap materi yang belum mereka kuasai. Manfaat dan dampak perubahan dari kegiatan pengabdian ini adalah peserta mampu membuat Curriculum Vitae sebagai bekal dalam melamar pekerjaan untuk dapat mempromosikan diri dan memberikan informasi mengenai kemampuan yang dimiliki sehingga memberi kesan yang kuat pada lembaga yang dituju. Peran dan kontribusi dari anggota tim pelaksana adalah mendampingi para peserta dalam mengikuti pelatihan
Pendampingan Olimpiade Sains Nasional Bidang Fisika Tingkat Kabupaten/Kota untuk Siswa SMAN Modal Bangsa Arun Lhokseumawe
Authors: Absa Munzir , Idris Syafrizal , Setiawan Tulus , Qausar Haves
Published: July 2024

Kompetisi Olimpiade Sains Nasional (OSN) adalah salah satu kompetisi bergengsi yang diminati oleh banyak siswa di seluruh penjuru negeri. Diharapkan dengan adanya kompetisi OSN ini, siswa dapat belajar dan berlatih dengan lebih keras untuk menguasai berbagai bidang sains dan teknologi yang bermanfaat untuk kemajuan bangsa dan negara. Kompetisi OSN dilakukan secara bertingkat mulai dari tingkat kabupaten/kota, tingkat provinsi, hingga tingkat nasional, untuk memberikan kesempatan yang sama dan adil bagi seluruh peserta didik di seluruh Indonesia. Nyatanya, tidak semua sekolah memiliki sumber daya yang sama untuk dapat mempersiapkan siswa-siswa nya berkompetisi dengan siswa-siswa dari sekolah lain. Salah satu sekolah yang memiliki masalah ini adalah SMAN Modal Bangsa Arun. Oleh karena itu, penulis melaksanakan pendampingan OSN bidang Fisika, sesuai bidang keahlian penulis, untuk siswa SMA tersebut. Pembimbingan ini dilakukan melalui beberapa tahapan, diantaranya diskusi dan observasi awal, pemberian tes awal (pretest), pemberian materi dan pembahasan soal, serta pemberian tes akhir (posttest). Setelah pelaksanaan pendampingan, didapati bahwa kemampuan siswa dalam menjawab soal-soal setingkat olimpiade meningkat, dimana nilai pretest rata-rata siswa adalah 30, dan nilai posttest rata-rata siswa adalah 70. Selain itu, satu dari lima orang siswa peserta pendampingan olimpiade berhasil lolos ke OSN tingkat provinsi. Ini menunjukkan bahwa kompetensi dan penguasaan siswa setelah pendampingan telah meningkat dibanding sebelum pendampingan. Diharapkan pula bahwa prestasi yang diraih dengan lolosnya seorang siswa ke OSN Fisika tingkat provinsi dapat menjadi motivasi bagi angkatan-angkatan yang datang kemudian untuk terus meningkatkan prestasi pribadi dan prestasi sekolah
Pemanfaatan Lahan Perkarangan Sebagai Peluang Usaha Di Gampong Meucat Kecamatan Nisam dengan Aplikasi Pupuk Hayati pada Budidaya Tanaman Hortikltura
Authors: Nazimah Nazimah , Nilahayati Nilahayati , Safrizal Safrizal , Mahdaliana Mahdaliana , Fachrurrazi Sayed
Published: July 2024

Aceh merupakan salah satu Provinsi di Indonesia yang menjadikan sektor pertanian sebagai tulang punggung perekonomian daerah.  Kota Lhokseumawe sebagai daerah penghasil minyak dan tempat beberapa pabrik pupuk berada, tak menampik bahwa sektor agraris banyak menghasilkan produk pertanian seperti tanaman perkebunan, tanaman pangan, dan tanaman hortikultura. Gampong (desa) Meucat Kecamatan Nisam merupakan salah satu gampong yang terletak tidak terlalu jauh dari kampus Universitas Malikussaleh,  Reulet  Aceh Utara. Kendala yang dihadapi oleh masyarakat Gampong Meucat yaitu belum bisa memanfaatkan  lahan perkarangan  secara maksimal,  sehingga tim pengabdian kepada masyarakat berkeinginan untuk memberdayakan masyarakat setempat  supaya dapat mengelola lahan perkarangan menjadi lahan yang produktif mulai dari pengolahan tanah sampai produksi. Tujuan dari kegiatan ini adalah untuk meningkatkan ketrampilan dan pengetahuan masyarakat  Gampong Meucat  dalam memanfaatkan lahan perkarangan yang tidak menghasilkan menjadi lahan produktif sehingga dapat menghasilkan produk pertanian khususnya tanaman hortikultura (Sayur – sayuran), yang nantinya akan menjadi salah satu sumber peluang usaha yang bisa meninggkatkan perekonomian dan kesejahteraan masyarakat.Metode yang dilakukan pada kegiatan ini antara lain yaitu melakukan kunjungan awal ke lokasi pengabdian, menyusun program kerja untuk tahapan kegiatan pengabdian , melaksanakan penyuluhan secara langsung dilapang tentang cara pegolahan tanah, teknik budidaya tanaman, serta teknik pembuatan pupuk hayati  dan cara aplikasi pada tanaman. Pelaksanaan pengabdian kepada masyarakatyang dilaksanakan  di Gampong Meucat Kecamatan Nisam memperlihatkan keseriusan masyarakat  dalam setiap sesi kegiatan , sehingga terjadi interaksi untuk mengadopsi ilmu pengetahuan yang kita sampaikan, masyarakat akan mengimplementasikan di lahan perkarangannya masing – masing yang selama ini tidak produkti akan menjadi lahan produktif sehingga menghasilkan sayuran organik yang berkualitas dan bernilai ekonomis, ini merupakan salah satu peluang usaha dalam bidang pertanian
Role of Pharmacogenetic Testing in the Risk and Safety Assessment of Valproates: The Ethnic Aspect (Review)
Authors: Shnayder N. A. , Grechkina V. V. , Arkhipov V. V. , Nasyrova R. F.
Published: July 2024

INTRODUCTION. Pharmacogenetic (PGx) testing plays a significant role in predicting the risk of adverse drug reactions (ADRs) associated with valproic acid (VPA) products, which are among the most prescribed medicinal products in neurology and psychiatry. However, the sensitivity and specificity of PGx screening panels may be insufficient as individual valproate metabolism varies across ethnically/racially diverse patient populations.

AIM. The study aimed to identify implementation areas for a personalised approach to the development of PGx panels for assessing the safety and risk of valproate therapy in various ethnic and racial groups residing in the Russian Federation.

DISCUSSION. The authors reviewed the results of population studies concerning the frequency of non-functional and low-function alleles of genes encoding isoenzymes that play key roles in VPA P-oxidation in the liver. This review focused on studies published in eLIBRARY.RU, PubMed, Scopus, and Google Scholar in 2012–2022. The inclusion criteria were full-text original articles, systematic reviews, meta-analyses, Cochrane reviews, and clinical cases in Russian or English. The analysis revealed that the need for personalised assessment of the risk and safety of VPA may depend on the frequency of risk alleles for slowing down VPA P-oxidation in the liver across racial and ethnic groups worldwide, and particularly in Russia. The authors identified new areas to implement the personalised approach to the development of PGx panels for assessing the safety and risk of valproate therapy with consideration of the rates of hepatic VPA P-oxidation in patients of different ethnic and racial backgrounds. However, the review of population-based associative genetic research from around the world demonstrated the current lack of clarity in the prospects of translating international findings directly into Russian clinical practice through the development of PGx panels due to Russia’s ethnic/racial diversity and vast territory.

CONCLUSIONS. To increase the sensitivity and specificity of Russian PGx panels, bridging studies are required to extrapolate the associations established between the most common risk alleles and VPA P-oxidation disorders in other ethnic groups to a specific population of a specific Russian region.
Modern terminology in the definition of alcoholic liver damage: new approaches to interaction with patients
Authors: Kharchenko N. V. , Shcherbynina M. B.
Published: July 2024

Recently, alcoholic damage has become one of the main causes of death from the liver diseases. The most important risk factors for the development of alcoholic liver disease (ALD) include the duration and amount of alcohol consumed. However, concomitant liver disease, obesity, metabolic syndrome, cigarette smoking, and female gender also increase the overall risk of ALD developing. Conditions related to alcohol consumption have various manifestations: from hepatosteatosis to severe acute hepatitis or its chronic course, cirrhosis and liver cancer. Historically, terms with an emphasis on the association with alcohol were used to describe these disorders, which are now considered stigmatizing. Stigma seriously affects such patients, leading to discrimination, reduced health care visits, and limited resource allocation, ultimately impairing clinical outcomes.In this regard, the medical community promotes modern terminology with an individual‑oriented approach. It is recommended that instead of terms that can be viewed as condemning, to use more neutral ones using sensitive wordings, such as «related to alcohol» or «associated with alcohol». The article provides modern terminology, which is recommended for the use in determining alcoholic liver damage.At the same time, it must be recognized that in addition to using the «right terms» it is important to create the «right environment» for people with alcohol consumption‑associated disorders and liver disease so that they can get the help they need. It is important that doctors, medical staff, and research coordinators interact with such patients in an impartial and non‑stigmatizing manner. Creating a supportive clinical and research environment is critical for the effective aids to the patients with ALD.
Efecto del uso de boquillas de aire inducido y adyuvante sobre la calidad de aplicación de fitosanitarios
Authors: Platz Juan Pedro , Bedmar Francisco , Manetti Pablo Luis , Echarte María Mercedes , Cendoya María Gabriela
Published: July 2024

Spraying of phytosanitary products must ensure efficient pest control while avoiding losses that could damage human health and environment. The objective of the study was to evaluate the effect of conventional hollow cone and air-induced hydraulic nozzles, and the addition of an adjuvant (Methylated Seed Oil [MSO]) upon the application quality of a fungicide (penetration, distribution, and uniformity) and losses due to endodrift on wheat and soybean canopies. In each crop, the experimental design was completely randomized,with four replications and a factorial arrangement of nozzles x adjuvant. Droplet spectrum was evaluated by using water-sensitive cards, and brilliant blue as a tracer in the application mixture. According to the results, the MSO did not homogenize the distribution of droplets generated by air-induced nozzles in the wheat canopy, as it depended on the crop height evaluated. In addition, the MSO reduced endodrift independently of the type of nozzle used. Thedistribution of droplets on the soybean canopy depended on the height and not on the type of nozzle nor the addition of MSO. The MSO and its combination with the nozzle type did not reduce endodrift in this crop.
Theoretical Perspectives on the Financialization of the Economy
Authors: Vernikov A. V. ,   Institute of Economics of the Russian Academy of Sciences, Kurysheva A. A. ,   Southern Federal University
Published: July 2024

This paper examines key research approaches that contribute to a critical reevaluation of financialization and its impacts. Financialization is understood as the expansion of the financial sector, its intrusion into social and private life, and the shift of non-financial companies toward financial transactions. This ideology priori­tizes financial metrics, often benefiting predominantly financial organizations. Several heterodox approaches challenge the mainstream view that an exaggerated financial sector is favorable for society. These approaches aim to create frameworks for alternative social orders and include institutional, macroeconomic, structural, spatial, socio­logical, and ethical perspectives addressing the risks of an excessively large financial sector. We particularly emphasize the financialization of households and its negative socio-economic consequences. Our findings indicate that, contrary to expectations, concerns about rampant financialization are more prevalent among sociologists, anthropologists, and psychologists than among economists. Russian researchers still predominantly view the role of finance in economic development as inherently positive. Few, if any, articles address the need for de-financialization, which involves reducing the absolute and relative weight of the financial and banking sectors in the eco­nomy and society. De-financialization could contribute to a broader framework to implement independent monetary poli­cy and a strategy for economic sovereignty, including reindustrialization efforts.
State and Development of the National Economy as a Complex System: Revising Paradigmatic Foundations
Authors: Biryukov V. V. ,   Omsk Humanitarian Academy
Published: July 2024

Radical economic changes highlight the importance of studying the fundamental aspects of national economic development, emphasizing the special role of the state. This article aims to clarify different strategies used to examine the economic role of the state and establish foundational paradigms for an alternative approach. It demonstrates that both mainstream and heterodox strategies are based on a common paradigm where economic entities are driven solely by private interests, positioning the state as an external entity that intervenes in the economy. This approach leads to the “tragedy of the commons,” where the state lacks a basis for regulating economic activity for the common good. The proposed paradigm rejects the traditional “homo economicus” model in favor of “homo economicus dualis,” recognizing the dual nature of economic actors. Within this approach, the focus is made on complex economic processes across three primary levels, assuming that people are the ultimate source and key actors of economic power. The state’s management of power relations is aimed at fostering sustainable economic development by balancing national and private interests. The article posits that the state, as the supreme authority on behalf of society, forms a system of property relations by establishing ownership and resource use rules. Consequently, the people, as the ultimate authority, also act as the supreme owners, making various institutional ownership forms manifestations of national ownership, of which all economic actors are co-owners. This understanding of the economic roles of the people and the state fosters realistic ideas about designing endogenous mechanisms for national economic development.
Interregional Migration Flows in Russia: A Network Approach
Authors: Smirnov A. V. ,   Institute of Socio-Economic and Energy Problems of the North of the Komi Science Centre of the Ural Branch of the RAS
Published: July 2024

Interregional migration in Russia surpasses both intraregional and international migration in vo­lume, playing a pivotal role in redistributing human capital across the country. To capture migration patterns between regions comprehensively, it is crucial to analyze all migration flows rather than just final migration indicators. This study integrates two research fields: network science, which examines various network structures, and the analysis of migration intensity coefficients, which helps account for differences in the sizes of regions of origin and destination. The article aims to use network science tools to study interregional migration flows in Russia from 2015 to 2023. It employs a methodology that combines network science techniques with migration intensity indicators. The study identifies five migration clusters with stable compositions throughout the review period, with transitions occurring only between Kaliningrad and Volgograd regions. Major migration hubs within each cluster and key migration flows are also identified. By calculating migration intensity coefficients and excluding flows between neighboring regions, the study identifies unusually large migration flows between remote northern and Arctic regions and labor resource donor regions. Conversely, unusually low migration flows between neighboring regions highlight limitations in the current transport infrastructure. Visualizations of Russia’s interregional migration network and migration intensity connections enhance the understanding of the country’s spatial mobility patterns.
Application of Labour Growth Theory to the Analysis of Soviet Stagnation
Authors: Zolotukhin A. A. ,   Independent researcher
Published: July 2024

The causes of stagnation and crisis in the Soviet economic system remain a topic of ongoing debate. Mainstream economists often attribute its downfall to fundamental flaws in its economic model. Conversely, heterodox economists argue that management errors, rather than planning itself, led to the crisis. Between these extremes lie numerous intermediate perspectives, underscoring the urgency of further study on this issue. This paper examines the dynamics of the Soviet economy through the lens of Labor Growth Theory (LGT), which offers a stochastic interpretation of the Labor Theory of Value (LTV). It explores several models of economic growth derived from endogenous LGT, applied to analyze the post-war Soviet GDP dynamics. The study aims to uncover the causes of Soviet stagnation through the lens of Labor Growth Theory (LGT). It includes a review of relevant literature on Soviet economic stagnation. The models developed within LGT accurately predicted the stagnation of the Soviet GDP in the 1970s and 1980s, based on trends observed in the 1950s and 1960s. Demographic factors and the monopoly of foreign trade are considered as primary causes of the stagnation. The paper also discusses potential alternative reforms that could have been pursued and evaluates the applicability of LGT for macroeconomic forecasting and its compatibility with LTV.
Legitimacy of Multinational Enterprises: Systematic Review and Research Agenda
Authors:   Graduate School of Management, St. Petersburg State University, Starshov E. D. , Fefelov D. L. ,   Graduate School of Management, St. Petersburg State University
Published: July 2024

Despite the growing academic interest in organizational legitimacy in the field of international business, the application of this concept varies widely. Our systematic literature review covers studies on legitimacy from the perspective of multinational enterprises (MNEs) over the past thirty years since the concept was introduced in the field. Our review comprises 72 articles from high-rated journals, which allows us to categorize the extant literature into various strands of research, discuss the evolutionary waves of research on MNE legitimacy, and provide directions for future inquiry. Additionally, we contribute by developing an integrative framework that offers a comprehensive understanding of the state-of-the-art theory on MNE legitimacy. We conclude that since the emergence of the concept, interest in it has grown across various management areas. Furthermore, while early research predominantly relied on institutional theory, the second wave saw a significant expansion of theoretical frameworks. In recent years, there has been an increase in articles addressing themes of ESG reporting and corporate social responsibility. Geographically, there is a noticeable increase in studies dedicated to emerging markets and MNEs from these countries. Besides systematizing knowledge, we contribute to the theory of international business by developing a comprehensive theoretical framework that reviews the antecedents for MNEs and their subsidiaries to acquire legitimacy, as well as the complexities and consequences of this process.
Antiretroviral Drugs Impact Autophagy: Opportunities for Drug Repurposing
Authors: Cheney Laura , Barbaro John M. , McDermott Grace , Berman Joan W.
Published: July 2024

Autophagy is an evolutionarily conserved process in which intracellular macromolecules are degraded in a lysosomal-dependent manner. It is central to cellular energy homeostasis and to quality control of intracellular components. A decline in autophagic activity is associated with aging, and contributes to the development of various age-associated pathologies, including cancer. There is an ongoing need to develop chemotherapeutic agents to improve morbidity and mortality for those diagnosed with cancer, as well as to decrease the cost of cancer care. Autophagic programs are altered in cancer cells to support survival in genetically and metabolically unstable environments, making autophagy an attractive target for new chemotherapy. Antiretroviral drugs, which have dramatically increased the life- and health spans of people with human immunodeficiency virus (HIV) (PWH), have offered promise in the treatment of cancer. One mechanism underlying the antineoplastic effects of antiretroviral drugs is the alteration of cancer cell autophagy that can potentiate cell death. Antiretroviral drugs could be repurposed into the cancer chemotherapy arsenal. A more complete understanding of the impact of antiretroviral drugs on autophagy is essential for effective repurposing. This review summarizes our knowledge of the effects of antiretroviral drugs on autophagy as potential adjunctive chemotherapeutic agents, and highlights gaps to be addressed to reposition antiretroviral drugs into the antineoplastic arsenal successfully.