bluuebunny/crossref_metadata_2025 huggingface dataset:
Holocene deglaciation and glacier readvances on the Fildes Peninsula and King George Island (Isla 25 de Mayo), South Shetland Islands, NW Antarctic Peninsula
Authors: Heredia Barión Pablo , Roberts Stephen J , Spiegel Cornelia , Binnie Steven A , Wacker Lukas , Davies Joanna , Gabriel Imogen , Jones Vivienne J , Blockley Simon , Pearson Emma J , Foster Louise , Davies Sarah J , Roland Thomas P , Hocking Emma P , Bentley Michael J , Hodgson Dominic A , Hayward Chris L , McCulloch Robert D , Strelin Jorge A , Kuhn Gerhard
Published: March 2023

To provide insights into glacier-climate dynamics of the South Shetland Islands (SSI), NW Antarctic Peninsula, we present a new deglaciation and readvance model for the Bellingshausen Ice Cap (BIC) on Fildes Peninsula and for King George Island/Isla 25 de Mayo (KGI) ~62°S. Deglaciation on KGI began after c. 15 cal. ka BP and had progressed to within present-day limits on the Fildes Peninsula, its largest ice-free peninsula, by c. 6.6–5.3 cal. ka BP. Probability density phase analysis of chronological data constraining Holocene glacier advances on KGI revealed up to eight 95% probability ‘gaps’ during which readvances could have occurred. These are grouped into four stages – Stage 1: a readvance and marine transgression, well-constrained by field data, between c. 7.4 and 6.6 cal. ka BP; Stage 2: four probability ‘gaps’, less well-constrained by field data, between c. 5.3 and 2.2 cal. ka BP; Stage 3: a well-constrained but restricted ‘readvance’ between c. 1.7 and 1.5 cal. ka BP; Stage 4: two further minor ‘readvances’, one less well-constrained by field data between c. 1.3 and 0.7 cal. ka BP (68% probability), and a ‘final’ well-constrained ‘readvance’ after <0.7 cal. ka BP. The Stage 1 readvance occurred as colder and more negative Southern Annular Mode (SAM)-like conditions developed, and marginally stronger/poleward shifted westerly winds led to more storms and precipitation on the SSI. Readvances after c. 5.3 cal. ka BP were possibly more frequent, driven by reducing spring/summer insolation at 62°S and negative SAM-like conditions, but weaker (equatorward shifted) Westerlies over the SSI led to reduced storminess, restricting readvances within or close to present day limits. Late Holocene readvances were anti-phased with subaquatic freshwater moss layers in lake records unaffected by glaciofluvial inputs. Retreat from ‘Neoglacial’ glacier limits and the recolonisation of lakes by subaquatic freshwater moss after 1950 CE is associated with recent warming/more positive SAM-like conditions.
Crucial but Overlooked: The Italian Naval Contribution to the Conquest of Sevastopol
Authors: Fiore Massimiliano
Published: March 2023

Axis land forces overran most of the Crimea in October 1941, but were unable to capture Sevastopol. Realizing that sea power was now necessary, Hitler ordered that light boats be transferred to the Black Sea. However, the Germans did not have a sufficient number of small boats at their disposal and asked the Italians to supply them. Based on a critique of archival sources, this article analyses this little-known aspect of the Black Sea campaign and argues that the Italian Flotilla made a crucial, although overlooked, contribution to Sevastopol's conquest, concluding that its activity prevented essential Soviet supply missions.
Childhood Sexual Abuse: A Longitudinal Study of Disclosures and Denials
Authors: Hartman Dana T. , Wang Yan , Wu Yuerui , Goldfarb Deborah , Vidales Daisy , Qin Jianjian , Eisen Mitchell L. , Goodman Gail S.
Published: March 2023

In legal cases regarding child sexual abuse (CSA), children have various options, such as to disclose or deny maltreatment. When interviewed in adulthood, their accounts may be consistent with their childhood responses. Alternatively, denial in childhood could be followed in adulthood by disclosure (“deferred disclosure”), confirming previous suspicions. Or the adults could possibly recant. We conducted a longitudinal study of CSA disclosures and denials ( N = 99; Time 1 [T1], 3- to 16-year-olds). T1 CSA disclosures and denials at a forensic unit were compared to the individuals’ responses 20 years later (Time 2 [T2]. 22- to 37-years-old). We found that consistent disclosure was associated with being older at T1 and female. Deferred disclosure was significantly associated with greater T2 trauma-related symptoms. Corroboration and higher CSA severity predicted T2 recantation. Consistent denial was related to less severe CSA. Our findings add to knowledge about CSA disclosures, which affect legal pathways available to child victims.
Psychological and Physical Lived Experiences of Journalists Covering Terrorism in Kenya
Authors: Muindi Benjamin
Published: March 2023

This research is based on 28 in-depth interviews with Kenya-based journalists who report terrorism. The objective of the research was to recount their lived experiences. The theme of safety of journalists comprised psychological and physical safety of the newspeople, and there were various ways in which the psychological and individual safety of the journalists covering terrorism and related events was at risk. The psychological safety included traumatic events leading to sleeplessness and nightmares, loss of memory, and some journalists resorting to alcohol abuse in a bid to cope with the traumatic experiences. These physical safety concerns for some journalists included threats of death by fanatical religious groups, while other participants said that they were threatened with death because of their coverage of terrorism and related activities in Kenya.
Combining multitask and transfer learning with deep Gaussian processes for autotuning-based performance engineering
Authors: Luszczek Piotr , Sid-Lakhdar Wissam M , Dongarra Jack
Published: March 2023

We combine deep Gaussian processes (DGPs) with multitask and transfer learning for the performance modeling and optimization of HPC applications. Deep Gaussian processes merge the uncertainty quantification advantage of Gaussian processes (GPs) with the predictive power of deep learning. Multitask and transfer learning allow for improved learning efficiency when several similar tasks are to be learned simultaneously and when previous learned models are sought to help in the learning of new tasks, respectively. A comparison with state-of-the-art autotuners shows the advantage of our approach on two application problems. In this article, we combine DGPs with multitask and transfer learning to allow for both an improved tuning of an application parameters on problems of interest but also the prediction of parameters on any potential problem the application might encounter.
Antibiotic Treatment in End Stage Cancer Patients; Advantages and Disadvantages
Authors: Mamak Tahmasebi , Hadiseh Hosamirudsari , Shirin Familrashtian , Masoud Parash , Mohammadreza Salehi , Mahsa Abbaszadeh
Published: March 2023

Aim:

In this study our aim was to elucidate whether advanced cancer patients benefit from antibiotic treatment in the last days of life in addition to reviewing the relevant costs and effects.

Materials And Methods:

We reviewed medical records from 100 end-stage cancer patients and their antibiotic use during the hospitalization in Imam Khomeini hospital. Patient’s medical records were analyzed retrospectively for cause and periodicity of infections, fever, increase in acute phase proteins, cultures, type and cost of antibiotic.

Results:

Microorganisms were found in only 29 patients (29%) and the most microorganism among the patients was E. coli (6%). About 78% of the patients had clinical symptoms. The highest dose of antibiotics was related to Ceftriaxone (40.2%) and in the second place was Metronidazole (34.7%) and the lowest dose was related to Levofloxacin, Gentamycin and Colistin (1.4%). Fifty-one patients (71%) did not have any side effects due to antibiotics. The most common side effect of antibiotics among patients was skin rash (12.5%). The average estimated cost for antibiotic use was 7 935 540 Rials (24.4 dollars).

Conclusion:

Prescription of antibiotics was not effective in symptom control in advanced cancer patients. The cost of using antibiotics during hospitalization is very high and also the risk of developing resistant pathogens during admission should be considered. Antibiotic side effects also occur in patients, causing more harm to the patient at the end of life. Therefore, the benefits of antibiotic advice in this time is less than its negative effects.
Prediction of Axillary Lymph Node Metastatic Load of Breast Cancer Based on Ultrasound Deep Learning Radiomics Nomogram
Authors: Zhang Heng , Zhao Tong , Zhang Sai , Sun Jiawei , Zhang Fan , Li Xiaoqin , Ni Xinye
Published: March 2023

Background: Axillary lymph node (ALN) metastatic load is very important in the diagnosis and treatment of breast cancer (BC). We aimed to construct a model for predicting ALN metastatic load using deep learning radiomics (DLR) techniques based on the preoperative ultrasound and clinicopathologic information of patients with stage T1-2 BC. Methods: Retrospective analysis was performed on 176 patients with pathologically confirmed BC in our hospital from February 2018 to April 2020. ALN metastases were divided into a low-load group (< 3 lymph node metastases) and a high-load group (≥ 3 lymph node metastases) according to pathological results. Pyradiomics and pre-trained ResNet50 were used to extract radiomics and deep learning features, respectively. Independent sample T-test, random forest recursive elimination, and Lasso were used to screen the features to construct the deep learning radiomics signature (DLRS). Based on single/multivariate logistic regression analysis results, a DLR nomogram (DLRN) model was constructed by combining valuable clinical features and DLRS. Results: The DLRS was composed of 3 radiomics features and 14 deep learning features and combined with the maximum diameter of lesions to construct the DLRN. The AUCs of the training and test sets were 0.900 (95% CI: 0.853-0.931) and 0.821 (95% CI: 0.769-0.868), respectively. The calibration curve and Hosmer–Lemeshow test confirmed that the DLRN model has a good consistency. The decision curve also confirmed its good clinical practicality. Conclusion: Ultrasound-based DLRN has an excellent performance in predicting ALN load in patients with BC.
Anti-Epileptogenesis: Some Roads Lead to Losartan
Authors: Sarkis Rani A.
Published: March 2023

[Box: see text]
The credibility of subgroup analyses reported in stroke trials is low: A systematic review
Authors: Ademola Ayoola , Thabane Lehana , Adekanye Joel , Okikiolu Ayooluwanimi , Babatunde Samuel , Almekhlafi Mohammed A , Menon Bijoy K , Hill Michael D , Hildebrand Kevin A , Sajobi Tolulope T
Published: March 2023

Background:

Subgroup analyses are widely used to evaluate the heterogeneity of treatment effects in randomized clinical trials. However, there is a limited investigation of the quality of prespecified and reported subgroup analyses in stroke trials. This study evaluated the credibility of subgroup analyses in stroke trials.

Methods and analysis:

We searched Medline/PubMed, Embase, the Cochrane Central Register of Controlled Trials, and the Web of Science from inception to 24 March 2021. Three reviewers screened, extracted, and analyzed the data from the publications. Primary publications of stroke trials that reported at least one subgroup effect and had published corresponding study protocols were included. The Instrument for Assessing the Credibility of Effect Modification Analyses (ICEMAN) was used to examine the quality of the subgroup effects reported, with each subgroup effect assigned a credibility rating ranging from very low to high. Subgroup effects with two or more “definitely no” responses received a low credibility rating. The risk of bias was assessed using the Cochrane Risk-of-Bias tool for randomized trials version 2.

Results:

Seventy-four articles met the inclusion criteria and reported a combined total of 647 subgroup effects. The median sample size was 1264 (interquartile range (IQR): 380–3876), and the median number of subgroups prespecified in the protocol was 6 (IQR: 2–10). Sixty-one (82%) studies used the univariate test of interaction. Of the total 647 subgroup effects reported in these studies, 319 (49%) were reported in acute stroke trials, while 423 (65%) had low credibility.

Conclusion:

The quality of subgroup analysis reporting in stroke trials remains poor. More effort is needed to train trialists on the best methods for designing and performing subgroup analyses, and how to report the results.

Trial registration number:

We prospectively registered the review with International Prospective Register for Systematic Reviews (registration number: CRD42020223133)
Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?
Authors: Hinton Jonathan , Augustine Maclyn , Gabara Lavinia , Mariathas Mark , Allan Rick , Borca Florina , Nicholas Zoe , Gillett Neil , Kwok Chun Shing , Cook Paul , Grocott Michael PW , Mamas Mamas , Curzen Nick
Published: March 2023

The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05–1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days.
Clinical Outcomes After ACL Reconstruction in Soccer (Football, Futbol) Players: A Systematic Review and Meta-Analysis
Authors: Hong Ian S. , Pierpoint Lauren A. , Hellwinkel Justin E. , Berk Alexander N. , Salandra Jonathan M. , Meade Joshua D. , Piasecki Dana P. , Fleischli James E. , Ahmad Christopher S. , Trofa David P. , Saltzman Bryan M.
Published: March 2023

Context:

The risk factors for anterior cruciate ligament (ACL) tear for athletes participating in pivoting sports includes young age and female sex. A previous meta-analysis has reported a reinjury rate of 15% after ACL reconstruction (ACLR) for athletes across all sports. To the best of the authors’ knowledge, this is the first systematic review and meta-analysis of available literature reporting outcomes after ACLR in soccer players.

Objective:

To review and aggregate soccer-specific outcomes data after ACLR found in current literature to help guide a more tailored discussion regarding expectations and prognosis for soccer players seeking operative management of ACL injuries.

Data Sources:

A comprehensive search of publications was performed using PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and SPORTDiscus databases.

Study Selection:

Inclusion criteria consisted of original studies, level of evidence 1 to 4, studies reporting clinical and patient-reported outcomes (PROs) after primary ACLR in soccer players at all follow-up length.

Study Design:

The primary outcomes of interest were graft failure/reoperation rates, ACL injury in contralateral knee, return to soccer time, and PROs.

Level of Evidence:

Level 4.

Data Extraction:

Search of literature yielded 32 studies for inclusion that involved 3112 soccer players after ACLR.

Results:

The overall graft failure/reoperation rate ranged between 3.0% and 24.8% (mean follow-up range, 2.3-10 years) and the combined ACL graft failure and contralateral ACL injury rate after initial ACLR was 1.0% to 16.7% (mean follow-up range, 3-10 years); a subgroup analysis for female and male players revealed a secondary ACL injury incidence rate of 27%, 95% CI (22%, 32%) and 10%, 95% CI (6%, 15%), respectively. Soccer players were able to return to play between 6.1 and 11.1 months and the majority of PROs showed favorable scores at medium-term follow-up.

Conclusion:

Soccer players experience high ACL injury rates after primary ACLR and demonstrated similar reinjury rates as found in previous literature of athletes who participate in high-demand pivoting sports.
Inflammatory bowel disease later diagnosed as strongyloides colitis in migrants to Canada: a case series
Authors: Raheel Hira , Kopalakrishnan Swana , Bhasker Shveta , Makhani Leila , Clarke Shareese , Nicholas Mathew N. , Mufti Asfandyar , Boggild Andrea K.
Published: March 2023

Strongyloides colitis is a gastrointestinal manifestation of the parasitic infection, Strongyloides stercoralis, which may be misdiagnosed and treated as ulcerative colitis (UC) in patients presenting in non-endemic regions. Treatment of Strongyloides colitis as UC can lead to a lethal hyperinfection syndrome. Therefore, prior to commencing immunosuppressive treatment of UC, it is essential to use diagnostic markers to differentiate the two etiologies. In this case series, we discuss two migrant patients who were previously diagnosed with UC and treated accordingly who presented to our clinic for further investigation of suspected parasitic infection.
Opportunities, associations, and impact of early intravenous to oral antimicrobial switch for hospitalized patients in Ethiopia
Authors: Tefera Gosaye Mekonen , Sileshi Tesemma , Mekete Mekonnen Derese , Umeta Gurmu Tesfaye
Published: March 2023

Objective:

Short intravenous antimicrobial therapy for 2–3 days followed by its per oral comparable antimicrobial course is a crucial part of the antimicrobial stewardship program. However, nothing is known about this practice in Ethiopian hospitals. Therefore, this study assessed the proportion, associations, and outcomes of early intravenous to per oral antimicrobial switch for patients who were admitted to the three wards of Ambo University Referral Hospital.

Method:

A hospital-based prospective cohort pilot study was conducted. During the 3-month period, 117 patients met initial inclusion criteria and were followed until Day 3 of intravenous antimicrobial. Of these, 92 (78.6%) subsequently met criteria for early intravenous to per oral switch and are the cohort investigated in this study. Written informed consent was sought from participants and/or parents or guardian for ages 15–17 years. Logistic regression models and independent t-tests were done with a significance of p ⩽ 0.05.

Results:

Out of 92 study participants, early intravenous to per oral antimicrobial switch was done only for 36 (39.1%). The only independent predictors for lack of early intravenous to per oral antimicrobials switch were poly-pharmacy (adjusted odds ratio = 3.4 at 95% confidence interval, 1.036–11.16; p = 0.044). There was a significant difference in terms of mean length of hospital stay (8.80 ± 3.57 versus 3.17 ± 0.74; p < 0.0001), in-hospital complication rate (95% versus 5%; p < 0.0001), and the mean cost of healthcare in Ethiopian Birrs (652.29 ± 403.29 versus 126.67 ± 29.47; p < 0.0001) between the comparator/early intravenous to per oral not switched and early switched group, respectively.

Conclusion:

The proportion of early intravenous to per oral antimicrobial switch was unsatisfactory. There was a significant difference between the intervention and comparator groups in terms of length of hospital stay, in-hospital complications, and extra cost. Therefore, implementation of interventions that improve the practice of early intravenous to per oral switch is needed urgently.
Plaque psoriasis and morphea in a patient on ustekinumab: A case report
Authors: Cirone Katrina , Vender Ronald
Published: March 2023

A large number of autoimmune and fibrosing conditions associated with psoriasis and morphea have been reported in the literature. Currently, the relationship between psoriasis and morphea is unknown, and the coexistence of these conditions is quite rare. Due to the few patients affected by both conditions, and the lack of knowledge concerning their pathogenic mechanisms, the cause behind this co-occurrence is poorly understood. Here, we present a case of morphea under a plaque of psoriasis in a patient managed on ustekinumab.
Thyroid dysfunction with atezolizumab plus bevacizumab after lenvatinib in hepatocellular carcinoma: A case series
Authors: Ichimura Takenori , Ichikura Daisuke , Hinata Miwa , Hida Noriko , Baba Toshiyuki
Published: March 2023

Atezolizumab plus bevacizumab is the recommended first-line treatment for unresectable hepatocellular carcinoma, based on guidelines from the Barcelona Clinic Liver Cancer prognosis and treatment strategy. However, atezolizumab plus bevacizumab may be used after administration of lenvatinib. Here, we present four patients who developed thyroid dysfunction after second-line treatment with atezolizumab plus bevacizumab, but not after lenvatinib alone. The patients were treated with lenvatinib and/or atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma at Showa University Northern Yokohama Hospital. Of patients treated with only lenvatinib or atezolizumab plus bevacizumab, 2/18 (11%) and 4/15 (27%) developed thyroid dysfunction, respectively. All four patients treated with atezolizumab plus bevacizumab after lenvatinib developed hypothyroidism after 2–14 doses of atezolizumab plus bevacizumab. Three patients developed Grade 2 symptoms and were treated with levothyroxine sodium. In patients with hepatocellular carcinoma, the incidence of thyroid dysfunction may be higher among patients treated with atezolizumab plus bevacizumab after lenvatinib than those treated with lenvatinib or atezolizumab plus bevacizumab alone.
Using shoe-mounted inertial sensors and stepping exergames to assess the motor-cognitive status of older adults: A correlational study
Authors: Guimarães Vânia , Sousa Inês , Bruin Eling D. de , Pais Joana , Correia Miguel Velhote
Published: March 2023

Objective

Stepping exergames designed to stimulate physical and cognitive skills can provide important information concerning individuals’ performance. In this study, we investigated the potential of stepping and gameplay metrics to assess the motor-cognitive status of older adults.

Methods

Stepping and gameplay metrics were recorded in a longitudinal study involving 13 older adults with mobility limitations. Game parameters included games’ scores and reaction times. Stepping parameters included length, height, speed, and duration, measured by inertial sensors placed on the shoes while interacting with the exergames. Parameters measured on the first gameplay were correlated against standard cognitive and mobility assessments, including the Montreal Cognitive Assessment (MoCA), gait speed, and the Short Physical Performance Battery. Based on MoCA scores, patients were then stratified into two groups: cognitively impaired and healthy controls. The differences between the two groups were visually inspected, considering their within-game progression over the training period.

Results

Stepping and gameplay metrics had moderate-to-strong correlations with cognitive and mobility performance indicators: faster, longer, and higher steps were associated with better mobility scores; better cognitive games’ scores and reaction times, and longer and faster steps were associated with better cognitive performance. The preliminary visual analysis revealed that the group with cognitive impairment required more time to advance to the next difficulty level, also presenting slower reaction times and stepping speeds when compared to the healthy control group.

Conclusion

Stepping exergames may be useful for assessing the cognitive and motor status of older adults, potentially allowing assessments to be more frequent, affordable, and enjoyable. Further research is required to confirm results in the long term using a larger and more diverse sample.
Combating Fake News and Digital Deception at the Workplace: An Integrative Review and Open Systems Theory-led Framework for Future Research
Authors: Vasist Pramukh Nanjundaswamy , Chatterjee Debashis
Published: March 2023

Research on fake news and related acts of deception in the domain of human resource management is growing but still in its infancy. This escalating crisis necessitates immediate attention, as fake news evolves into an all-pervasive phenomenon that surpasses domain boundaries and affects organizations at scale. This study analyzes the growing corpus of research on fake news and concomitant acts of deceit in the domain of human resource management through an integrative review of 64 scholarly papers published in peer-reviewed journals over the last 30 years. We identify key themes and draw attention to gaps that merit scrutiny. We then propose an open systems theory-led conceptual framework that elucidates the relationships between fake news, related acts of deceit and its effects on various facets of human resource management practice and serves as a guide to advance contributions in the field. Directions for future research and implications for practice are discussed.
Paper 03: Suprascapular Neuropathy: Two Distinct Presentations and Outcomes of Decompression
Authors: McCarthy Conor , Bishop Kristen , Kirby Hannah , Susmarski Adam , Dickens Jonathan , Kilcoyne Kelly , LeClere Lance
Published: March 2023

Objectives:

Suprascapular neuropathy due to nerve compression or tension at the suprascapular notch is an uncommon source of shoulder pain and rotator cuff weakness with recent increased recognition and treatment. Long considered an elusive diagnosis, work-up can be lengthy and patients may experience treatment delay. We aimed to review presentation patterns and outcomes of arthroscopic suprascapular nerve decompression in a predominantly young and active military population.

Methods:

The surgical databases of two surgeons were queried for patients treated with arthroscopic suprascapular nerve decompression at the suprascapular notch from 2013 to 2021. Patient data, presentation and workup findings, and outcome measures were collected through review of the electronic medical record. Primary outcome measures were rate of return to active-duty military service, shoulder abduction and external rotation strength, and VAS pain scores. Secondary outcome measures were American Shoulder and Elbow Surgeons (ASES) Shoulder Score, Visual Analogue Scale (VAS), and Single Assessment Numerical Evaluation (SANE) score.

Results:

Twenty-five patients were identified. Average age was 26.6 years and follow-up 17.9 months (4-62 months). There were two distinct primary presentation types in this cohort: the chief complaint was pain in 13 patients (52%) and weakness in 12 (48%). Supraspinatus and/or infraspinatus atrophy was present on MRI in 10/12 patients with weakness and 0/13 with pain. Electromyography was positive in 9/12 with weakness and negative when obtained in 5 patients with pain. Ultrasound-guided suprascapular nerve injection was performed in 10/13 with pain and provided mean 91% symptom relief. Patients with pain had longer duration of pre-operative symptoms (22.2 [±13.1] vs. 10.3 [±13.6] weeks). Postoperatively, the pain group had significant improvement in VAS scores (6.2 [±1.6] to 1.0 [±0.9]), while the weakness group had significant improvement in abduction and external rotation motor grading (3.7 [±0.7] to 4.7 [±0.4] and 3.3 [±0.8] to 4.4 [±0.6] respectively). Return to duty or sport was 92% at a mean of 14.6 (±9.3) weeks.

Conclusions:

In this young, active cohort, suprascapular neuropathy presented with one of two distinct primary presenting complaints: pain or weakness. Given different expected work-up findings, categorizing patients into one of these two groups may be beneficial in effectively diagnosing and treating suprascapular neuropathy. Outcomes after arthroscopic suprascapular nerve release at the suprascapular notch predictably led to successful pain relief and strength improvement in patients presenting with pain and weakness respectively. [Table: see text][Table: see text]
Paper 07: The True Learning Curve in Hip Arthroscopy According to Patient-Reported Outcomes
Authors: Westermann Robert
Published: March 2023

Objectives:

Arthroscopic correction of FAI is a powerful way to improve pain and function in athletes and patients. Surgeons learning hip arthroscopy experience a learning curve while gaining competence. The objective of the present study was to evaluate the learning curve in hip arthroscopy for FAI according to improvements in patient-reported outcome instruments.

Methods:

A retrospective review was performed of a single surgeon’s first 1000 hip arthroscopy cases during their first 4 years in practice. Arthroscopy cases that occurred concurrently with PAO or femoral osteotomy (n=360) were excluded. Convenience samples (n=50) were taken from each year in practice. Pre-operative and post-operative HOOS- Pain and HOOS-physical function scores were obtained. Linear trends were assessed, and cutoffs for MCID for HOOS (10 points) were surveyed across time. Students t tests were used for continuous variables and chi squared tests were used for categorical variables and significance was set to p<0.05.

Results:

During the first 250 cases, a sample of patients was obtained (n=50), and 11/50 did not meet MCID (22%) for HOOS Pain at 1-year follow-up. A convenience sample of cases subsequent to this from cases 251-1000 (n=100) 11/100 after that did not meet MCID (11.0%, p<0.05). The mean 1-year postop HOOS Pain score for year 1 was 82.77, year 2 was 90.56, year 3 was 89.34 and year 4 was 93.48 (P<0.05). Delta HOOS Pain of PS did not change over time, p>0.05). For both HOOS Pain and Physical Function subscales, 1-year postop scores continued to improve over the 4-year 1000-case study period (graph).

Conclusions:

According to the HOOS validated patient reported outcome instrument, the learning curve for significant benefits in hip arthroscopy is between 130-250 cases. Many patients (almost 80%) saw significant clinical benefit during the learning curve, however the quality of outcome was significantly improved after 250 cases. 1-year post-op PROs appear to continually improve even after cases 750-1000
Filling the Void: The Role of Adult Siblings Caring for a Brother or Sister With Severe Mental Illness
Authors: Kitzmüller Gabriele , Wiklund Gustin Lena , Kalhovde Anne Martha
Published: March 2023

Little is known about the role of adult siblings’ caregiver role within the context of mental illness. Therefore, our purpose was to explore how siblings narrate their experiences of being the main caregivers of a brother or sister with severe mental illness and how they cooperate with their ill sibling and their family of origin. We used a narrative hermeneutic approach and performed a secondary analysis of two interviews of siblings derived from a study of peoples’ experiences of hearing voices. The findings illuminate the participants’ multifaceted roles and how differently siblings might deal with the multiple challenges of caring for an ill sibling. The mediating role between their ill sibling and their family of origin to reestablish the broken family bonds was a significant aspect. Nurses’ awareness of the important and multidimensional role of caregiving siblings can improve the provision of family support and promote involvement of siblings in the treatment of an ill family member.
Agile Project Management and Emotional Exhaustion: A Moderated Mediation Process
Authors: Augner Tabea , Schermuly Carsten Christoph
Published: March 2023

This article tested a moderated mediation process to explain the relationship between agile project management and emotional exhaustion. By transferring traditional stress theories to the agile context, work-related stress was introduced as a mediator, and the moderating effects of social competence, perceived team support, and a culture for psychological empowerment were evaluated. The results of two complementary field studies with 307 project employees indicated that higher levels of agile project management lowered project employees’ emotional exhaustion by reducing their work-related stress levels. This negative indirect relationship is significantly stronger when the organization fosters a culture for psychological empowerment.
Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms
Authors: Nannya Yasuhito , Tobiasson Magnus , Sato Shinya , Bernard Elsa , Ohtake Shigeki , Takeda June , Creignou Maria , Zhao Lanying , Kusakabe Manabu , Shibata Yuhei , Nakamura Nobuhiko , Watanabe Mizuki , Hiramoto Nobuhiro , Shiozawa Yusuke , Shiraishi Yuichi , Tanaka Hiroko , Yoshida Kenichi , Kakiuchi Nobuyuki , Makishima Hideki , Nakagawa Masahiro , Usuki Kensuke , Watanabe Mitsumasa , Imada Kazunori , Handa Hiroshi , Taguchi Masataka , Kiguchi Toru , Ohyashiki Kazuma , Ishikawa Takayuki , Takaori-Kondo Akifumi , Tsurumi Hisashi , Kasahara Senji , Chiba Shigeru , Naoe Tomoki , Miyano Satoru , Papaemanuil Elli , Miyazaki Yasushi , Hellström-Lindberg Eva , Ogawa Seishi
Published: March 2023

Azacitidine is a mainstay of therapy for myelodysplastic syndrome (MDS)–related diseases. The purpose of our study is to elucidate the effect of gene mutations on hematological response and overall survival (OS), particularly focusing on their posttreatment clone size. We enrolled a total of 449 patients with MDS or related myeloid neoplasms. They were analyzed for gene mutations in pretreatment (n = 449) and posttreatment (n = 289) bone marrow samples using targeted-capture sequencing to assess the impact of gene mutations and their posttreatment clone size on treatment outcomes. In Cox proportional hazard modeling, multihit TP53 mutation (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.42-2.91; P < .001), EZH2 mutation (HR, 1.71; 95% CI, 1.14-2.54; P = .009), and DDX41 mutation (HR, 0.33; 95% CI, 0.17-0.62; P < .001), together with age, high-risk karyotypes, low platelets, and high blast counts, independently predicted OS. Posttreatment clone size accounting for all drivers significantly correlated with International Working Group (IWG) response (P < .001, using trend test), except for that of DDX41-mutated clones, which did not predict IWG response. Combined, IWG response and posttreatment clone size further improved the prediction of the original model and even that of a recently proposed molecular prediction model, the molecular International Prognostic Scoring System (IPSS-M; c-index, 0.653 vs 0.688; P < .001, using likelihood ratio test). In conclusion, evaluation of posttreatment clone size, together with the pretreatment mutational profile as well as the IWG response play a role in better prognostication of azacitidine-treated patients with myelodysplasia.
Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis
Authors: Suzuki Yuzo , Fukada Atsuki , Mori Kazutaka , Kono Masato , Hasegawa Hirotsugu , Hashimoto Dai , Yokomura Koshi , Imokawa Shiro , Inoue Yusuke , Yasui Hideki , Hozumi Hironao , Karayama Masato , Furuhashi Kazuki , Enomoto Noriyuki , Fujisawa Tomoyuki , Inui Naoki , Nakamura Hidenori , Suda Takafumi
Published: March 2023

Background

Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is characterised by upper lobe-dominant fibrosis involving the pleura and subpleural lung parenchyma, with advanced cases often complicated by progressive weight loss. Therefore, we hypothesised that nutritional status is associated with mortality in IPPFE.

Methods

This retrospective study assesses nutritional status at the time of diagnosis and 1 year after diagnosis in 131 patients with IPPFE. Malnutrition-related risk was evaluated using the Geriatric Nutritional Risk Index (GNRI).

Results

Of the 131 patients, 96 (73.8%) were at malnutrition-related risk at the time of diagnosis according to the GNRI. Of these, 21 patients (16.0%) were classified as at major malnutrition-related risk (GNRI <82). Patients at major malnutrition-related risk were significantly older and had worse pulmonary function than patients at low (GNRI 92– <98) and moderate (GNRI 82– <92) malnutrition-related risk. GNRI scores decreased significantly from the time of diagnosis to 1 year after diagnosis. Patients with a lower GNRI (<91.8) had significantly shorter survival than patients with a median GNRI or higher (≥91.8). Patients with declines in annual GNRI scores of ≥5 had significantly shorter survival than patients with declines in annual GNRI scores of <5. In multivariate analysis, major malnutrition-related risk was significantly associated with increased mortality after adjustment for age, sex and forced vital capacity (hazard ratio 1.957). A composite scoring model including age, sex and major malnutrition-related risk was able to separate mortality risk in IPPFE.

Conclusion

Assessment of nutritional status by the GNRI provides useful information for managing patients with IPPFE by predicting mortality risk.
Do not discount the diagnosis of VKH based on race: self-reported race and ethnicity of patients with Vogt-Koyanagi-Harada disease in a predominantly white population
Authors: Deák Gábor Gy. , Koreishi Anjum F. , Goldstein Debra A.
Published: March 2023

Background

We examined the racial and ethnic distribution of patients with Vogt-Koyanagi-Harada disease (VKH) in a Midwestern US population through a retrospective chart review of patients with VKH seen in a tertiary referral centre between 2012 and 2017. All patients were diagnosed by one uveitis specialist (DAG). We identified 32 patients with VKH seen during this time period. The mean age at diagnosis was 37.7 ± 15.7 years, 7 were male, 25 female. Mean follow-up was 36.7 ± 21.7 months. Nine patients reported themselves as White non-Hispanic, (28.1%), 9 as Black/African-American (28.1%), 2 as Asian (6.3%) and 9 as Hispanic or Latino (28.1%). Three patients (9.4%) were of Middle-Eastern origin. The 2010 census results for race and ethnicity in the state of Illinois were: 71.5% White, 14.5% Black/African-American, 4.6% Asian, and 6.7% as Some Other Race. From the total population 15.8% reported themselves as Hispanic or Latino (of any race).

Conclusions

VKH was much more frequent among white non-Hispanic patients (28.1%) and Black/African-American patients (28.1%) in our patient population than in previous reports from the US (3–14% and 4–23% respectively). While Hispanic patients in this series were over represented in the VKH population compared with the overall census data, the percentage of VKH patients in this series who were White non-Hispanic and Hispanic was the same. The diagnosis of VKH should be considered in any patient with the appropriate clinical features, regardless of race or ethnicity.
Characterization of host and escherichia coli strains causing recurrent urinary tract infections based on molecular typing
Authors: Kao Cheng-Yen , Zhang Yen-Zheng , Yang Deng-Chi , Chen Pek Kee , Teng Ching-Hao , Lin Wei-Hung , Wang Ming-Cheng
Published: March 2023

Background

Escherichia coli is the leading pathogen responsible for urinary tract infection (UTI) and recurrent UTI (RUTI). Few studies have dealt with the characterization of host and bacteria in RUTI caused by E. coli with genetically identical or different strains. This study aimed to investigate the host and bacterial characteristics of E. coli RUTI based on molecular typing.

Results

Patients aged 20 years or above who presented with symptoms of UTI in emergency department or outpatient clinics between August 2009 and December 2010 were enrolled. RUTI was defined as patients had 2 or more infections in 6 months or 3 or more in 12 months during the study period. Host factors (including age, gender, anatomical/functional defect, and immune dysfunction) and bacterial factors (including phylogenicity, virulence genes, and antimicrobial resistance) were included for analysis. There were 41 patients (41%) with 91 episodes of E. coli RUTI with highly related PFGE (HRPFGE) pattern (pattern similarity > 85%) and 58 (59%) patients with 137 episodes of E. coli RUTI with different molecular typing (DMT) pattern, respectively. There was a higher prevalence of phylogenetic group B2 and neuA and usp genes in HRPFGE group if the first episode of RUTI caused by HRPFGE E. coli strains and all episodes of RUTI caused by DMT E. coli strains were included for comparison. The uropathogenic E. coli (UPEC) strains in RUTI were more virulent in female gender, age < 20 years, neither anatomical/ functional defect nor immune dysfunction, and phylogenetic group B2. There were correlations among prior antibiotic therapy within 3 months and subsequent antimicrobial resistance in HRPFGE E. coli RUTI. The use of fluoroquinolones was more likely associated with subsequent antimicrobial resistance in most types of antibiotics.

Conclusions

This study demonstrated that the uropathogens in RUTI were more virulent in genetically highly-related E. coli strains. Higher bacterial virulence in young age group (< 20 years) and patients with neither anatomical/functional defect nor immune dysfunction suggests that virulent UPEC strains are needed for the development of RUTI in healthy populations. Prior antibiotic therapy, especially the fluoroquinolones, within 3 months could induce subsequent antimicrobial resistance in genetically highly-related E. coli RUTI.
HOTAIR regulates SIRT3-mediated cardiomyocyte survival after myocardial ischemia/reperfusion by interacting with FUS
Authors: Liu Jixuan , Sun Mingzhuang , Wang Jinda , Sun Zhijun , Wang Gang
Published: March 2023

Background

Myocardial ischemia/reperfusion (I/R) contributes to serious myocardial injury and even death. Therefore, prevention and mitigation of myocardial I/R is particularly important. LncRNA HOTAIR has been reported to be implicated in myocardial I/R progression. However, the detailed molecular mechanism of HOTAIR in cardiomyocyte was explored in myocardial I/R.

Methods

Firstly, cell model of myocardial I/R was established through hypoxia/reoxygenation (H/R). Apoptosis and cell cycle were evaluated utilizing flow cytometry. The corresponding test kits were conducted to monitor the levels of LDH, Caspase3 and Caspase9. The gene expression and protein levels were detected by qPCR and western blot, respectively. RNA pull-down and RIP were performed to verify the interaction between FUS and lncRNA HOTAIR.

Results

In AC16 cardiomyocytes treated with H/R, lncRNA HOTAIR and SIRT3 expression were obviously decreased. Overexpression of HOTAIR or SIRT3 could ameliorate H/R-induced cardiomyocyte injury by promoting cell viability, lowering LDH levels, and suppressing cell apoptosis. Further, lncRNA HOTAIR upregulated the expression of SIRT3 via interacting with FUS, thereby promoting the survival of H/R-injured cardiomyocytes.

Conclusion

LncRNA HOTAIR can improve myocardial I/R by affecting cardiomyocyte survival through regulation of SIRT3 by binding to the RNA binding protein FUS.
Experience in diagnosis and treatment of duodenal ulcer perforation in children
Authors: Shen Qiulong , Liu Tingting , Wang Siwei , Wang Li , Wang Dayong
Published: March 2023

Background

This study aims to summarize our experience in diagnosis and treatment of pediatric duodenal ulcer perforation in a National Center for Children’s Health.

Methods

Fifty-two children with duodenal perforation hospitalized in Beijing Children’s Hospital Affiliated to Capital Medical University from January 2007 to December 2021 were retrospectively collected. According to the inclusion and exclusion criteria, patients with duodenal ulcer perforation were included in the group. They were divided into the surgery group and the conservative group according to whether they received surgery.

Results

A total of 45 cases (35 males and 10 females) were included, with a median age of 13.0 (0.3–15.4) years. Forty cases (40/45, 88.9%) were over 6 years old, and 31 (31/45, 68.9%) were over 12 years old. Among the 45 cases, 32 cases (32/45, 71.1%) were examined for Helicobacter pylori (HP), and 25 (25/32, 78.1%) were positive. There were 13 cases in the surgery group and 32 cases in the conservative group, without a significant difference in age between the two groups (P = 0.625). All cases in the surgery group and the conservative group started with abdominal pain. The proportion of history time within 24 h in the two groups was 6/13 and 12/32 (P = 0.739), and the proportion of fever was 11/13 and 21/32 (P = 0.362). The proportion of pneumoperitoneum in the surgery group was higher than that in the conservative group (12/13 vs. 15/32, P = 0.013). The fasting days in the surgery group were shorter than those in the conservative group (7.7 ± 2.92 vs. 10.3 ± 2.78 days, P = 0.014). There was no significant difference in the total hospital stay (13.6 ± 5.60 vs14.8 ± 4.60 days, P = 0.531). The operation methods used in the surgery group were all simple sutures through laparotomy (9 cases) or laparoscopy (4 cases). All patients recovered smoothly after surgery.

Conclusion

Duodenal ulcer perforation in children is more common in adolescents, and HP infection is the main cause. Conservative treatment is safe and feasible, but the fasting time is longer than the surgery group. A simple suture is the main management for the surgery group.
Empathy level towards patients among thai dental students: a cross-sectional study
Authors: Detsomboonrat Palinee , Theppanich Sudthida , Banyen Suttida , Hongviphat Sansern , Khamnil Yutthana , Lapauthaya Komsun , Somboonsavatdee Anupap , Min Saw Nay
Published: March 2023

Background

This study aimed to develop the Jefferson scale of Empathy - Health Professions student version (JSE-HPS) for the dental student in the Thai version and assess the empathy level in students across gender, universities, and year of dental education.

Methods

JSE-HPS original version was translated to develop the draft Thai JSE-HPS version and was administered to 5 dental students for a pilot test. The final questionnaires (JSE-HPS) were completed by 439 dental students from five public universities and one private in Thailand in the 2021–2022 academic year. The internal consistency and reliability (test-retest) of the questionnaires were tested by using Cronbach’s alpha and intraclass correlation coefficient (ICC). Factor analysis was used to examine the underlying factors of the JSE-HPS (Thai language).

Results

The JSE-HPS represented good internal consistency (Cronbach’s α = 0.83). Factor analysis revealed, “Compassionate Care”, “Perspective Taking” and “Ability to stand in Patients’ Shoes” as the first, second, and third factors, respectively. The mean empathy score of dental students was 114.30 (SD = 13.06) from the total score of 140. There were no significant differences in the empathy levels among genders, study programs, grades, universities, regions, types of universities, and years of study.

Conclusion

The findings confirm the reliability and validity of the JSE-HPS (Thai version) to measure the empathy level among dental students. Integrating empathic elements into the dental curriculum will help student learning to be more effective and improve treatment outcomes.