bluuebunny/crossref_metadata_2025 huggingface dataset:
Verbbunddecken bei Hochhäusern aus Stahlbeton.
Authors: König G. , Maurer R. , Milbrecht G.
Published: March 2013

Es wird über Versuche und ausgeführte Beispiele mit dem Cofrastra‐Verbunddeckensystem berichtet. Hierbei wirkt das verzinkte Trapezblech nicht nur als verlorene Schalung, sondern in das Blech eingewalzte Noppen dienen zur Verbundsicherung zwischen Blech und Beton. Für den speziellen Einsatz im Hochhausbau, wo die Wandkletterschalung dem Deckenbau weit vorauseilt, wird ein speziell entwickeltes Auflagerungsdetail zur Erteilung der baurechtlichen Zulassung im Versuch beurteilt.
Verstärken von Betonbauteilen ‐ Ziele, Verfahren und Techniken.
Authors: Iványi G.
Published: March 2013

Ziele, Verfahren und Techniken des Verstärkens von Betonbauteilen werden formuliert und Hinweise für die Anwendung gegeben. Als typische Verfahren gelten die Verstärkung durch Spritzbeton, das Ankleben von Stahllaschen und die Bewehrung in Ritzen und Nuten, die durch Hochdruckwasserstrahl erzeugt wurden.
Die "kurze" Zylinderschale.
Authors: Schaller G.
Published: March 2013

Auf Grundlage der klassischen Berechnung, d.h. der Integration von Differentialgleichungen werden die Schnittkräfte in der kurzen Zylinderschale (Schalenlänge <= 3 x elastische Länge) bestimmt und tabellarisch aufbereitet.
Plattenbrücken ‐ teilweise ohne Verbund vorgespannt.
Authors: Iványi G. , Buschmeyer W.
Published: March 2013

Es wird über das Auslegungskonzept teilweise ohne Verbund vorgespannter Plattenbrücken berichtet. Anhand einer Parameterstudie werden Hilfsmittel zum Vorentwurf und Anregungen zur Wahl eines sinnvollen Vorspanngrads zur Erfüllung hoher Dauerfestigkeitsansprüche gegeben.
Computer‐unterstütztes Bemessen mit Stabwerkmodellen.
Authors: Rückert K. J.
Published: March 2013

Es wird über Entwicklung und Anwendung eines graphik‐gestützten Computerprogramms zur Bemessung im Stahlbetonbau mit Stabwerksmodellen berichtet.
Zur Optimierung der Vorspannung von Flachdecken.
Authors: Küttner D.
Published: March 2013

Es werden die dimensionslosen Momentenbeiwerte einer flächigen Vorspannung denen einer in den Gurtstreifen konzentrierten Vorspannung gegenübergestellt. Die in den Gurtstreifen konzentrierte Vorspannung ist wirksamer.
Zur Untersuchung des Traglastverhaltens vorgespannter Linientragwerke.
Authors: Rosemeier G.‐E.
Published: March 2013

Nach der Einführung von Eurocode 2 sind in Zukunft Traglastverfahren auch für vorgespannte Konstruktionen zulässig. Unter Benutzung des FEM‐Standardprogramms SAP wird nachgewiesen, daß der statisch unbestimmte Momentenanteil aus Vorspannung nur gering durch die Rißbildung beeinflußt wird, so daß dieser Anteil genügend genau durch den Rechenwert des Zustands I angenähert werden kann.
Firstrisse in der Innenschale großer Tunnel ‐ Ursachen und Wege zur Vermeidung (Teil 1).
Authors: Springenschmid R. , Plannerer M.
Published: March 2013

In den letzten 15 Jahren konnte mit konstruktiven, betontechnologischen und baupraktischen Maßnahmen die Rißbildung bei Tunneln der DB‐Neubaustrecken sehr stark verringert werden. Nur in seltenen Fällen traten nach Monaten oder Jahren Längsrisse in der Firste auf. Wie statische Berechnungen, die auf Messungen am Beton von Tunneln beruhen, zeigen, entstehn Firstrisse durch Biege‐Zwangspannungen vor allem infolge rascher Abkühlung (Temperaturgradient) und stärkerem Trocknungsschwinden (Schwindgradient) an der Luftseite. Die beim Ausschalen auftretenden Spannungen aus Eigenlast sind so klein, daß Druckfestigkeiten von 3 N/mm� ausreichen. Durch die konsequente Anwendung konstruktiver, betontechnologischer und baupraktischer Maßnahmen bleibt das Risiko einer späteren Rißbildung klein.
Klebeverbund‐Versagen unter statischer und dynamischer Beanspruchung.
Authors: Hankers Ch. , Rostásy F.S.
Published: March 2013

Versuche an mit Stahllaschen verstärkten Betonbauteilen zeigten den Bruch innerhalb der Klebeschicht. Diese Versagensart tritt unter dynamischer Beanspruchung als Folge eines progressiven Rißwachstums auf. Es wurden Bruchkriterien für dieses Klebstoffversagen entwickelt und Ansätze zur Modellierung des Schädigungsfortschritts gezeigt. Das Verbundversagen im Betonuntergrund ist bereits in [1] erläutert worden.
Verstärken von Betontragwerken mit geklebter äußerer Bewehrung aus kohlenstoffaserverstärkten Kunststoffen.
Authors: Rostásy F. S. , Neubauer U. , Hankers Ch.
Published: March 2013

Lamellen aus kohlenstoffaserverstärktem Kunststoff (CFK‐Lamellen) oder Kohlenstoffaserfolien (CF‐Folien) als geklebte äußere Bewehrung für die Bauwerksverstärkung haben gegenüber Stahllaschen wesentliche Vorteile. Diese ergeben sich aus ihrer sehr hohen Kurzzeit‐ und Ermüdungsfestigkeit bei geringstem Gewicht und dem hervorragenden Widerstand gegen chemische Angriffe. Es wird ein Überblick über die Werkstoffe, ihre Eigenschaften, das Tragverhalten CFK‐verstärkter Biegebauteile sowie deren Bemessung gegeben. Probleme des Verbundversagens werden angesprochen und abschließend einige der bisherigen Anwendungen beschrieben.
Alternative Ausbildung der Randelemente von Stahlbeton‐Wandscheiben für Erdbebenbeanspruchung.
Authors: Keintzel E.
Published: March 2013

Es wird eine von der Anwendungsregel in Eurocode 8 abweichende, alternative Ausbildung der Randelemente von Stahlbeton‐Wandscheiben für Erdbebenbeanspruchung vorgeschlagen. Zu ihrer Herleitung werden die bei der Bestimmung der Umschnürungsbewehrung in den kritischen Bereichen von Stützen angewandten Überlegungen auf den Wandscheibenquerschnitt als Ganzes übertragen. Die Anwendung des vorgeschlagenen Konzepts kann insbesondere bei Wandscheiben mit niedriger bezogener Längskraft zu einer bedeutenden Abminderung der nach der EC‐8‐Regel erforderlichen Umschnürungsbewehrung führen.
100 Jahre Forschung in der Betontechnologie ‐ Von der Empirie zur Werkstoffwissenschaft
Authors: Hilsdorf H. K.
Published: March 2013

Einführend werden der Stand der Betontechnologie um die Jahrhunderwende sowie die ersten experimentellen Untersuchungen geschildert. Dann wird auf die frühen Arbeiten eingegangen, welche die Grundlagen für einen gezielten Mischungsentwurf von Beton bildeten. Die Entwicklung der zur Betonherstellung erforderlichen Ausgangsstoffe wird kurz dargestellt. Dann werden einige der wesentlichsten wissenschaftlichen Arbeiten in der Betontechnologie, die während der zweiten Hälfte dieses Jahrhunderts entstanden sind, erläutert. Dazu gehören Untersuchungen über die Mikrostruktur von Zementstein und Beton, über das Bruchverhalten bei Druck‐ oder Zugbeanspruchung sowie über die mechanischen Eigenschaften von Beton und die dazugehörigen Stoffgesetze. Schließlich werden Untersuchungen zu Problemen der Dauerhaftigkeit von Beton sowie des Transports von Flüssigkeiten und Gasen in Beton geschildert. Der abschließende Abschnitt enthält einen kurzen Ausblick auf zukünftige Forschungsaufgaben.
Tragfähigkeit dreiseitig eingespannter Rechteckplatten mit einem freien Rand nach der Fließgelenklinientheorie
Authors: Herzog M.
Published: March 2013

Es wird die Berechnung der Tragfähigkeit dreiseitig eingespannter Rechteckplatten mit einem freien Rand unter gleichmäßig verteilter und unter hydrostatischer Last mit dem Fließgelenklinienverfahren gezeigt und an Hand von zwei Zahlenbeispielen mit der bisher üblichen "elastischen" Berechnung verglichen.
Möglichkeiten zur Verstärkung von Stahlbetonbauteilen
Authors: Hankers C.
Published: March 2013

Belastung, Veränderungen am statischen System, Korrosion der Bewehrung, Fehler in der Bemessung führen zur Notwendigkeit des Verstärkens von Betonbauteilen. Der Beitrag stellt die verschiedenen Verfahren dar, wobei auf die Verstärkung mit Spritzbeton und Bewehrung sowie auf die Methode der geklebten Bewehrung näher eingegangen wird. Beide Verfahren werden in technischer und wirtschaftlicher Hinsicht verglichen. Alle Verstärkungsmaßnahmen stellen einen gravierenden Eingriff in die bestehende Bausubstanz dar. Eine statische Berechnung ist daher immer erforderlich. Bei älteren Bauwerken muß zudem geprüft werden, ob die ursprünglichen Nachweisverfahren noch ausreichende Sicherheit bieten können, oder ob eine Neudimensionierung erforderlich ist. Für die verstärkten Bauteile sind die Anforderungen an den Brandschutz nachzuweisen.
Lebensdauerbemessung‐ Zuverlässigkeitsberechnungen zur wirksamen Vermeidung von verschiedenartig induzierter Bewehrungskorrosion
Authors: Gehlen Ch.
Published: March 2013

Im Rahmen eines europäisch finanzierten Brite‐Euram Projektes ist ein neues Lebensdauerbemessungskonzept für bewehrte Betonbauteile erarbeitet worden. Es ist nun möglich, eingebettet in ein Sicherheitskonzept, prüfbar und rechnerisch verarbeitbar eine grenzzustandsbezogene Bauteildauerhaftigkeit (Lebensdauer) unter Angabe von Versagenswahrscheinlichkeiten vorherzusagen. Das Bemessungsverfahren wurde bereits zur Dauerhaftigkeitsbemessung eines Bohrtunnels in den Niederlanden und zur Lebensdauerabschätzung eines Brückenbauwerks in Süddeutschland eingesetzt.
Tragverhalten von vorgespannten Bauteilen aus Hochleistungsbeton
Authors: Hegger J. , Görtz St. , Kommer B. , Will N.
Published: March 2013

Hochleistungsbetone ermöglichen die Erfüllung der Forderung nach großen Stützweiten, geringen Rohbaukosten bei einer gleichzeitig hohen Ausführungsqualität. Der Beitrag stellt das für die Anwendung notwendige Wissen zur Biege‐ und Querkrafttragfähigkeit vorgespannter Träger aus Hochleistungsbeton dar.
ChemInform Abstract: Crystal Structures of the High Temperature Forms of V8O15 and V9O17 and Structural Trends in the VnO2n‐1 Magneli Series.
Authors: Allred J. M. , Cava R. J.
Published: March 2013

The structures of the metallic high‐temperature forms of the title compounds are determined by single crystal XRD.
ChemInform Abstract: High‐Pressure Syntheses and Characterization of the Rare Earth Borates Ln5(BO3)2F9 (Ln: Dy, Ho).
Authors: Hinteregger Ernst , Boehler Gerhard , Hofer Thomas S. , Huppertz Hubert
Published: March 2013

The new title compounds are synthesized in a Walker‐type multianvil apparatus from mixtures of Ln2O3 (Ln: Dy, Ho), LnF3, and B2O3 at 1.5 GPa and 1250 °C for the Dy compound, and at 2.5 GPa and 1200 °C for the Ho compound.
ChemInform Abstract: Novel Alkaline Earth Copper Germanates with Ferro and Antiferromagnetic S = 1/2 Chains.
Authors: Brandao Paula , Reis Mario S. , Gai Zheng , dos Santos Antonio M.
Published: March 2013

Two new compounds, CaCuGeO4·H2O (I) and BaCu2Ge3O9·H2O (II), are hydrothermally synthesized from aqueous mixtures of CuSO4, Ca(OH)2 or Ba(OH)2, and GeO2 (autoclave, 230 °C, 7 d).
ChemInform Abstract: Activation of Molecular Oxygen by a Metal—Organic Framework with Open 2,2′‐Bipyridine for Selective Oxidation of Saturated Hydrocarbons.
Authors: Long Jilan , Wang Liming , Gao Xingfa , Bai Cuihua , Jiang Huanfeng , Li Yingwei
Published: March 2013

A metal—organic framework (MOF 253) can efficiently activate molecular oxygen for selective oxidation of a variety of saturated hydrocarbons with unprecedented activities and selectivities.
ChemInform Abstract: A Simple and Straightforward Approach Toward Selective C=C Bond Reduction by Hydrazine.
Authors: Chen Hao , Wang Jianmin , Hong Xuechuan , Zhou Hai‐Bing , Dong Chune
Published: March 2013

18 representative examples of the title reaction with C=C bonds in various steric and electronic environments are reported.
ChemInform Abstract: Formylation of Amines Catalyzed by Protic Ionic Liquids under Solvent‐Free Condition.
Authors: Majumdar Swapan , De Jhinuk , Hossain Jewel , Basak Ajoy
Published: March 2013

A convenient protocol employing an ionic liquid as catalyst under solvent free conditions allows the N‐formylation of a variety of amines.
ChemInform Abstract: Copper‐Catalyzed Enantioselective Synthesis of Axially Chiral Allenes.
Authors: Li Hailing , Mueller Daniel , Guenee Laure , Alexakis Alexandre
Published: March 2013

This method yields axially chiral chloroallenes with good enantioselectivity, which can be further transformed to trisubstituted allenes or terminal alkynes with propargylic quarternary stereocenters.
ChemInform Abstract: CuSO4·5H2O‐Catalyzed Alkynylphosphonates Formation — An Efficient Coupling Reaction of Terminal Alkynes with H‐Phosphonates.
Authors: Qu Zhibo , Chen Xiaolan , Yuan Jinwei , Qu Lingbo , Li Xu , Wang Fujun , Ding Xiling , Zhao Yufen
Published: March 2013

The title reactions shows a wide functional group tolerance affording alkynylphosphonates (22 examples) in good yields under mild conditions.
ChemInform Abstract: PhI(OAc)2‐Mediated Oxidative Trifluoromethylation of Arenes with CF3SiMe3 under Metal‐Free Conditions.
Authors: Wu Xinyue , Chu Lingling , Qing Feng‐Ling
Published: March 2013

The title reaction provides a direct method for the preparation of trifluoromethylated arenes without the need of prefunctionalization.
ChemInform Abstract: Base Promoted Highly Efficient Copper Fluorapatite Catalyzed Coupling of Phenols with Arylboronic Acids under Mild and Ligand‐Free Conditions.
Authors: Mulla Shafeek A. R. , Inamdar Suleman M. , Pathan Mohsinkhan Y. , Chavan Santosh S.
Published: March 2013

The first report of a recyclable, heterogeneous, ecofriendly, inexpensive copper fluoroapatite catalyzed coupling reaction of phenols with arylboronic acids is described.
ChemInform Abstract: Lewis Acid‐Catalyzed Oxidation of Benzylamines to Benzamides.
Authors: Wu Xiao‐Feng , Bheeter Charles Beromeo , Neumann Helfried , Dixneuf Pierre H. , Beller Matthias
Published: March 2013

A novel Lewis acid‐catalyzed oxidation of primary and secondary benzylamines to the corresponding amides using tBuOOH as the terminal oxidant is described.
ChemInform Abstract: A Highly Efficient Friedel—Crafts Reaction of Tertiary α‐Hydroxyesters or α‐Hydroxyketones to α‐Quaternary Esters or Ketones.
Authors: Chen Long , Zhou Jian
Published: March 2013

43 examples of a catalytic Friedel‐Crafts arylation of α‐hydroxyesters or α‐hydroxyketones with electron‐rich aromatic compounds are reported.
ChemInform Abstract: Application of Zirconacyclopentadienes (Metalla‐Heterocycles) and Cross‐Coupling for the Convenient Preparative Method of 6,13‐Disubstituted Pentacene.
Authors: Jia Zhiying , Li Shi , Nakajima Kiyohiko , Kanno Ken‐ichiro , Song Zhiyi , Takahashi Tamotsu
Published: March 2013

Diiododihydropentacene (II) is used for the introduction of substituents at position 6 and 13 via standard C—C cross‐coupling reactions.
ChemInform Abstract: Calcium Iodide Catalyzed Photooxidative Oxylactonization of Oxocarboxylic Acids Using Molecular Oxygen as Terminal Oxidant.
Authors: Tada Norihiro , Ishigami Takafumi , Cui Lei , Ban Kazunori , Miura Tsuyoshi , Itoh Akichika
Published: March 2013

The title reaction allows the conversion of 4‐benzoylbutyric acids into the corresponding five‐membered lactones.
ChemInform Abstract: Synthesis of cis‐Octahydroindoles via Intramolecular 1,3‐Dipolar Cycloaddition of 2‐Acyl‐5‐aminooxazolium Salts.
Authors: Basch Corey H. , Brinck Jameson A. , Ramos Joaquin E. , Habay Stephen A. , Yap Glenn P. A.
Published: March 2013

An efficient two‐step method for the synthesis of the title compounds is presented with excellent diastereoselectivity.
ChemInform Abstract: Synthesis of Substituted Amines and Isoindolinones: Catalytic Reductive Amination Using Abundantly Available AlCl3/PMHS.
Authors: Kumar Vishal , Sharma Sushila , Sharma Upendra , Singh Bikram , Kumar Neeraj
Published: March 2013

A wide range of aldehydes and ketones as well as primary and secondary amines are applied in the reaction.
ChemInform Abstract: Copper‐Catalyzed Synthesis of Benzocarbazoles via α‐C‐Arylation of Ketones.
Authors: Xie Ruilong , Ling Yun , Fu Hua
Published: March 2013

The title reaction uses readily available 2‐(2‐bromophenyl)‐indoles (I) and ketones (II) and (IV) as starting materials.
ChemInform Abstract: β‐Lactam Synthon‐Interceded Diastereoselective Synthesis of Functionalized Octahydroindole‐Based Molecular Scaffolds and Their in vitro Cytotoxic Evaluation.
Authors: Singh Pardeep , Raj Raghu , Bhargava Gaurav , Hendricks Denver T. , Handa Sachin , Slaughter LeGrande M. , Kumar Vipan
Published: March 2013

Various C‐3 functionalized β‐lactam derivatives of type (I) are used as starting materials for diastereoselective title reactions.
ChemInform Abstract: Synthesis of Oxazoles from Enamides via Phenyliodine Diacetate‐Mediated Intramolecular Oxidative Cyclization.
Authors: Zheng Yunhui , Li Xuming , Ren Chengfeng , Zhang‐Negrerie Daisy , Du Yunfei , Zhao Kang
Published: March 2013

This method yields highly functionalized oxazoles from readily available enamides.
ChemInform Abstract: Sulfamic Acid: An Efficient, Cost‐Effective and Recyclable Catalyst for the Synthesis of Triazole[1,2‐a]indazole‐trione Derivatives.
Authors: Kidwai Mazaahir , Chauhan Ritika
Published: March 2013

This three‐component one‐pot condensation in water affords the title compounds in high yields under mild conditions.
ChemInform Abstract: Synthesis of Some Series of 1,3‐Thiazolidin‐4‐ones and Indoles Incorporating Furoxan Moiety Starting with Anethole Isolated from Star Anise Oil.
Authors: Nguyen Huu Dinh , Nguyen Quang Trung , Nguyen Dang Dat , Nguyen Hien
Published: March 2013

Some of the synthesized compounds show low in vitro antimicrobial activities.
ChemInform Abstract: Chiral Primary Amine Tagged to Ionic Group as Reusable Organocatalyst for Asymmetric Michael Reactions of C‐Nucleophiles with α,β‐Unsaturated Ketones.
Authors: Kucherenko Alexander S. , Siyutkin Dmitry E. , Nigmatov Albert G. , Chizhov Alexander O. , Zlotin Sergei G.
Published: March 2013

For the first time a simple recoverable immobilized organocatalyst for the title reaction is synthesized.
ChemInform Abstract: Double Nucleophilic Attack on Isocyanide Carbon: A Synthetic Strategy for 7‐Aza‐tetrahydroindoles.
Authors: Li Yifei , Xu Xianxiu , Xia Chunyu , Zhang Lingjuan , Pan Ling , Liu Qun
Published: March 2013

A novel strategy for the synthesis of title compounds (III)/(IV) and (VI)/(VII) from alkenoylacetamides (I) and (V) and isonitrile (II) is described.
ChemInform Abstract: Synthesis of Novel Pyrazolo[3,4‐d]pyrimidine Derivatives as Potential anti‐Breast Cancer Agents.
Authors: Abd El Hamid Mohammed K. , Mihovilovic Marko D. , El‐Nassan Hala B.
Published: March 2013

Novel pyrazolo[3,4‐d]pyrimidine derivatives (IV) are synthesized and screened for their cytotoxic activity against the human breast cancer cell line MCF7.
ChemInform Abstract: Synthesis of Indeno[2′,1′:5,6]pyrido[2,3‐d]pyrimidine Derivatives and Their Recognition Properties as New Type Anion Receptors.
Authors: Shi Da‐Qing , Li Yan , Wang Hai‐Ying
Published: March 2013

The new type anion receptors (IV) are obtained via three‐component reaction of aldehydes, 6‐aminopyrimidine‐2,4‐dione, and 1,3‐indanedione in aqueous media.
ChemInform Abstract: Tandem Imino‐Pinacol Coupling‐Aza‐Michael Reaction Promoted by Zn/InCl3: A Novel Multicomponent Strategy for Diastereoselective Synthesis of Monocyclic 1,4‐Diazepine in Water.
Authors: Siddiqui I. R. , Shamim Shayna , Kumar Devesh , Shireen Shireen , Waseem Malik A.
Published: March 2013

An efficient one‐pot protocol for the synthesis of 1,4‐diazepines in excellent yields and with high diastereoselectivities is presented.
ChemInform Abstract: Antimalarial Spiro‐Bridged 1,2‐Dioxolanes via Intramolecular Addition of Peroxycarbenium Ions to C—C Double Bonds.
Authors: Li Yun , Wittlin Sergio , Wu Yikang
Published: March 2013

Title compounds [(II), (III), and (V)] are synthesized from geminal dihydroperoxide (I) with intramolecular [3 + 2] cycloaddition of in situ generated peroxycarbenium ions to the C—C double bond as the key step.
ChemInform Abstract: Mechanochemical Synthesis of Hydrogen Storage Materials
Authors: Huot J. , Ravnsbaek D. B. , Zhang J. , Cuevas F. , Latroche M. , Jensen T. R.
Published: March 2013

Review: 282 refs.
ChemInform Abstract: Spin Transport in Ferromagnet/III‐V Semiconductor Heterostructures
Authors: Crowell Paul A. , Crooker Scott A.
Published: March 2013

Review: 104 refs.
ChemInform Abstract: Electronic Spectroscopy: Ultra Violet‐Visible and Near IR Spectroscopies
Authors: Jentoft Friederike C.
Published: March 2013

Review: 144 refs.
ChemInform Abstract: Fundamentals, Properties and Applications of Solid Catalysts Prepared by Solution Combustion Synthesis (SCS)
Authors: Gonzalez‐Cortes Sergio L. , Imbert Freddy E.
Published: March 2013

Review: 128 refs.
ChemInform Abstract: Synthesis of Two Neurokinin NK1 Receptor Antagonists: (+)‐L‐733,060 and (—)‐L‐733,061.
Authors: Cochi Anne , Gomez Pardo Domingo , Cossy Janine
Published: March 2013

Review: 73 refs.
ChemInform Abstract: Metal‐Catalyzed Amide Bond Forming Reactions in an Environmentally Friendly Aqueous Medium: Nitrile Hydrations and Beyond
Authors: Garcia‐Alvarez Rocio , Crochet Pascale , Cadierno Victorio
Published: March 2013

Review: 305 refs.
ChemInform Abstract: The 125th Anniversary of the Troeger′s Base Molecule: Synthesis and Applications of Troeger′s Base Analogues
Authors: Runarsson Oegmundur Vidar , Artacho Josep , Waernmark Kenneth
Published: March 2013

Review: 124 refs.
ChemInform Abstract: Carbon Nanomaterials in Catalysis: Proton Affinity, Chemical and Electronic Properties, and Their Catalytic Consequences
Authors: Zhu Jun , Holmen Anders , Chen De
Published: March 2013

Review: about 200 refs.
ChemInform Abstract: Transition‐Metal Catalyzed C—C Bond Formation Using Organobismuth Compounds
Authors: Shimada Shigeru , Rao Maddali L. N.
Published: March 2013

Review: 73 refs.
ChemInform Abstract: Bismuth‐Catalyzed Addition of Silyl Nucleophiles to Carbonyl Compounds and Imines
Authors: Ollevier Thierry
Published: March 2013

Review: 159 refs.
ChemInform Abstract: Development and Application of Isocyanide‐Based Multicomponent Reactions
Authors: Zhu Jieping , Wang Qian , Wang Mei‐Xiang
Published: March 2013

Review: 171 refs.
ChemInform Abstract: Synthetic Methods. Part 2. Oxidation and Reduction Methods
Authors: Howard James K. , Hyland Christopher J. T.
Published: March 2013

Review: 136 refs.
ChemInform Abstract: Supramolecular Bidentate Phosphorus Ligands
Authors: van der Vlugt Jarl Ivar , Reek Joost N. H.
Published: March 2013

Review: 80 refs.
ChemInform Abstract: Single Molecule Sensing with Solid‐State Nanopores: Novel Materials, Methods, and Applications
Authors: Miles Benjamin N. , Ivanov Aleksandar P. , Wilson Kerry A. , Dogan Fatma , Japrung Deanpen , Edel Joshua B.
Published: March 2013

Review: 68 refs.
Investigation of Evaporative Emissions Restraint Systems for Bioethanol‐Fuel Blends
Authors: Schieferstein Eva , Schlüter Stefan , Hennig Torsten , Meller Karl , Lange Marcus , Möller Andreas
Published: March 2013

Kraftstoffdampfrückhaltesysteme (KDRS) werden in Fahrzeugen eingesetzt, um die Emissionen leichtflüchtiger Kohlenwasserstoffe in die Atmosphäre zu verhindern. Bis 2020 sollen 10 % der Kraftstoffe durch Biokraftstoffe ersetzt werden, wobei Bioethanol eine entscheidende Rolle spielt. In dieser Arbeit wird die Funktionstüchtigkeit von KDRS bei Verwendung von Bioethanol/Kraftstoff‐Gemischen untersucht. Hierzu werden Aktivkohlen, die bereits in KDRS eingesetzt werden, getestet. Erhaltene Ergebnisse und Messdaten fließen in ein mathematisches Modell ein, das die Funktionsweise von KDRS in Abhängigkeit der Bioethanol/Kraftstoff‐Zusammensetzung simuliert.
A multichannel relay MAC protocol for IEEE 802.11 wireless LANs
Authors: Kim Dong‐Wook , Lim Wan‐Seon , Suh Young‐Joo
Published: March 2013

One of the challenging issues in wireless LANs (WLANs) is improving the network throughput. One of the possible solutions for the issue is maximizing the number of concurrent transmissions. Although some protocols have been proposed to exploit transmission concurrency in WLANs, their performance depends on the degree of the interference among links. Also, it is hard to obtain interference information because of their dynamics. In this paper, we propose an enhanced medium access control (MAC) protocol for WLANs, named multichannel relay MAC (MRMAC), which is able to transmit multiple frames simultaneously without considering interference. To enable concurrent transmissions, MRMAC adopts the concept of frame relaying. Furthermore, MRMAC utilizes several nonoverlapping channels to eliminate interferences. Through extensive simulations, we found that MRMAC shows better performance than existing well‐known MAC protocols. Copyright © 2013 John Wiley & Sons, Ltd.
Nanoaggregates of Simple Mn Porphyrin Complexes as Catalysts for the Selective Oxidation of Hydrocarbons
Authors: Rezaeifard Abdolreza , Soltani Vahideh , Jafarpour Maasoumeh
Published: March 2013

A stable suspension of simple manganese(III) meso‐tetraphenylporphyrin nanoaggregates was prepared by a host–guest procedure, in which ethanol and water are used as “green” solvents. The organic nanoparticles were studied by dynamic light scattering (DLS), AFM, and UV/Vis and fluorescence spectroscopy. The results indicate that the nanoaggregates have a spherical morphology with sizes between 15–40 nm. The epoxidation of olefins and oxygenation of saturated hydrocarbons by PhI(OAc)2 were efficiently enhanced with excellent selectivity under the influence of simple Mn(TPP)OAc (TPP = meso‐tetraphenylporphyrin) nanoparticles. Enhanced stabilities and activities were achieved with nanostructured Mn catalysts compared to those of the individual counterparts in solution according to turnover numbers and UV/Vis studies. The title nanocatalyst facilitates a greener reaction because the reaction solvent is a water/ethanol mixture and PhI(OAc)2 is safe to use. The efficiency of the oxidation system depends critically upon the steric hindrances and electronic structures of both nitrogen donor ligands and porphyrin nanoparticles.
Integration of Spin‐Coated Nanoparticulate‐Based La0.6Sr0.4CoO3–δ Cathodes into Micro‐Solid Oxide Fuel Cell Membranes
Authors: Evans A. , Benel C. , Darbandi A. J. , Hahn H. , Martynczuk J. , Gauckler L. J. , Prestat M.
Published: March 2013

Thin cathodes for micro‐solid oxide fuel cells (micro‐SOFCs) are fabricated by spin‐coating a suspension of La0.6Sr0.4CoO3–δ (LSC) nanoparticulates obtained by salt‐assisted spray pyrolysis. The resulting 250 nm thin LSC layers exhibit a three‐dimensional porous microstructure with a grain size of around 45 nm and can be integrated onto free‐standing 3 mol.% yttria‐stabilized‐zirconia (3YSZ) electrolyte membranes with high survival rates. Weakly buckled micro‐SOFC membranes enable a homogeneous distribution of the LSC dispersion on the electrolyte, whereas the steep slopes of strongly buckled membranes do not allow for a perfect LSC coverage. A micro‐SOFC membrane consisting of an LSC cathode on a weakly buckled 3YSZ electrolyte and a sputtered Pt anode has an open‐circuit voltage of 1.05 V and delivers a maximum power density of 12 mW cm–2 at 500 °C.
Next‐generation‐sequencing‐based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia
Authors: Chen Cai , Bartenhagen Christoph , Gombert Michael , Okpanyi Vera , Binder Vera , Röttgers Silja , Bradtke Jutta , Teigler‐Schlegel Andrea , Harbott Jochen , Ginzel Sebastian , Thiele Ralf , Fischer Ute , Dugas Martin , Hu Jianda , Borkhardt Arndt
Published: March 2013

Near haploidy (23–29 chromosomes) is a numerical cytogenetic aberration in childhood acute lymphoblastic leukemia (ALL) associated with particularly poor outcome. In contrast, high hyperdiploidy (51–67 chromosomes) has a favorable prognosis. Correct classification and appropriate risk stratification of near haploidy is frequently hampered by the presence of apparently high hyperdiploid clones that arise by endoreduplication of the original near haploid clone. We evaluated next‐generation‐sequencing (NGS) to distinguish between “high hyperdiploid” leukemic clones of near haploid and true high hyperdiploid origin. Five high hyperdiploid ALL cases and the “high hyperdiploid” cell line MHH‐CALL‐2, derived from a near haploid clone, were tested for uniparental isodisomy. NGS showed that all disomic chromosomes of MHH‐CALL‐2, but none of the patients, were of uniparental origin, thus reliably discriminating these subtypes. Whole‐exome‐ and whole‐genome‐sequencing of MHH‐CALL‐2 revealed homozygous non‐synonymous coding mutations predicted to be deleterious for the protein function of 63 genes, among them known cancer‐associated genes, such as FANCA, NF1, TCF7L2, CARD11, EP400, histone demethylases, and transferases (KDM6B, KDM1A, PRDM11). Only eight of these were also, but heterozygously, mutated in the high hyperdiploid patients. Structural variations in MHH‐CALL‐2 include a homozygous deletion (MTAP/CDKN2A/CDKN2B/ANRIL), a homozygous inversion (NCKAP5), and an unbalanced translocation (FAM189A1). Together, the sequence variations provide MHH‐CALL‐2 with capabilities typically acquired during cancer development, e.g., loss of cell cycle control, enhanced proliferation, lack of DNA repair, cell death evasion, and disturbance of epigenetic gene regulation. Poorer prognosis of near haploid ALL most likely results from full penetrance of a large array of detrimental homozygous mutations. © 2013 Wiley Periodicals, Inc.
Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas
Authors: Bianchini Laurence , Birtwisle Loïc , Saâda Esma , Bazin Audrey , Long Elodie , Roussel Jean‐François , Michiels Jean‐François , Forest Fabien , Dani Christian , Myklebost Ola , Birtwisle‐Peyrottes Isabelle , Pedeutour Florence
Published: March 2013

Most lipomas are characterized by translocations involving the HMGA2 gene in 12q14.3. These rearrangements lead to the fusion of HMGA2 with an ectopic sequence from the translocation chromosome partner. Only five fusion partners of HMGA2 have been identified in lipomas so far. The identification of novel fusion partners of HMGA2 is important not only for diagnosis in soft tissue tumors but also because these genes might have an oncogenic role in other tumors. We observed that t(1;12)(p32;q14) was the second most frequent translocation in our series of lipomas after t(3;12)(q28;q14.3). We detected overexpression of HMGA2 mRNA and protein in all t(1;12)(p32;q14) lipomas. We used a fluorescence in situ hybridization‐based positional cloning strategy to characterize the 1p32 breakpoint. In 11 cases, we identified PPAP2B, a member of the lipid phosphate phosphatases family as the 1p32 target gene. Reverse transcription‐polymerase chain reaction analysis followed by nucleotide sequencing of the fusion transcript indicated that HMGA2 3′ untranslated region (3′UTR) fused with exon 6 of PPAP2B in one case. In other t(1;12) cases, the breakpoint was extragenic, located in the 3′region flanking PPAP2B 3′UTR. Moreover, in one case showing a t(1;6)(p32;p21) we observed a rearrangement of PPAP2B and HMGA1, which suggests that HMGA1 might also be a fusion partner for PPAP2B. Our results also revealed that adipocytic differentiation of human mesenchymal stem cells derived from adipose tissue was associated with a significant decrease in PPAP2B mRNA expression suggesting that PPAP2B might play a role in adipogenesis. © 2013 Wiley Periodicals, Inc.
Seawater recharge into oceanic crust: IODP Exp 327 Site U1363 Grizzly Bare outcrop
Authors: Wheat C. Geoffrey , Hulme Samuel M. , Fisher Andrew T. , Orcutt Beth N. , Becker Keir
Published: March 2013

Systematic differences in sediment thermal and pore water chemical profiles from Integrated Ocean Drilling Program Site U1363 document mixing and reaction within the basaltic crust adjacent to Grizzly Bare outcrop, a site of hydrothermal recharge into 3.6 My‐old basaltic crust. A transect of seven holes was drilled ~50 m to ~750 m away from the base of the outcrop. Temperatures at the sediment‐basement interface increase from ~6°C to >30°C with increasing distance from the outcrop, and heat flow is suppressed within several hundred meters from the outcrop. Calculated fluid compositions at the sediment‐basement interface are generally explained by mixing between bottom seawater and altered crustal basement fluids, with a composition similar but not identical to fluids from seeps at Baby Bare outcrop, located ~45 km to the northeast. Reactions within upper basement and overlying sediment affect a variety of ions (Mn, Fe, Mo, Si, PO43‐, V, and U) and δ13DIC, indicating a diagenetic influence and diffusive exchange with overlying sediment pore waters. The apparent 14C age of basal pore fluids is much older than bottom seawater. Collectively, these results are consistent with seawater recharge at Grizzly Bare outcrop; however, there are strong gradients in fluid composition within 50 m of the outcrop, providing evidence for complex flow paths and vigorous mixing of young, recently recharged seawater with much older, more reacted basement fluid. The proximity of these altered fluids to the edge of the outcrop raises the possibility for fluid seepage from the outcrop in addition to seawater recharge.
Randomized controlled study of the T‐type calcium channel antagonist MK‐8998 for the treatment of acute psychosis in patients with schizophrenia
Authors: Egan Michael F. , Zhao Xin , Smith Andrew , Troyer Matthew D. , Uebele Victor N. , Pidkorytov Valerii , Cox Kevin , Murphy Michael , Snavely Duane , Lines Christopher , Michelson David
Published: March 2013

Objective

This study aimed to evaluate whether the T‐type calcium channel antagonist MK‐8998 was effective in treating acute psychosis in patients with schizophrenia.

Methods

This was a randomized, double‐blind, parallel‐group study. After a placebo lead‐in, acutely psychotic inpatients with schizophrenia were randomized to 4 weeks of MK‐8998 12/16 mg daily (N = 86), olanzapine 10/15 mg daily (N = 47), or placebo (N = 83). The primary efficacy measure was score on the Positive and Negative Syndrome Scale (PANSS).

Results

Out of 216 randomized patients, 158 completed the 4‐week study: MK‐8998 = 58 (67.4%), olanzapine = 38 (80.9%), and placebo = 62 (74.7%). The mean changes from baseline in PANSS score at week 4 for MK‐8998 and olanzapine were not significantly different from placebo: MK‐8998–placebo difference = −0.6 [95% confidence interval (CI): −7.0, 5.8], p = 0.9; olanzapine–placebo difference = −4.3 [95% CI: −11.7, 3.1), p = 0.3. A responder rate analysis (≥20% improvement from baseline in PANSS score) suggested an advantage of olanzapine over placebo (odds ratio = 2.20 [95% CI: 0.95, 5.09], p = 0.07) but no effect of MK‐8998 over placebo (odds ratio = 1.28 [95% CI: 0.62, 2.64], p = 0.5). Treatments were generally well tolerated, but more patients reported adverse events for MK‐8998 (47.7%) and olanzapine (48.9%) than placebo (37.3%).

Conclusions

MK‐8998 was not effective in treating acutely psychotic inpatients with schizophrenia, as measured by PANSS score at week 4. Because of the limited efficacy of the active comparator, we cannot exclude the possibility that T‐type calcium channel antagonists could prove to be effective in schizophrenia. Copyright © 2013 John Wiley & Sons, Ltd.
Movement disorders in patients with schizophrenia and a history of substance abuse
Authors: Hansen Lars K. , Nausheen Bina , Hart Deborah , Kingdon David
Published: March 2013

Objective

The movement disorders acute dystonia, akathisia, Parkinsonian symptoms and tardive dyskinesia [extrapyramidal side effects (EPSs)] are recognized adverse effects of antipsychotic medication. Previous studies have indicated that substance abuse in patients with schizophrenia can worsen EPS. This study therefore investigated the relationship between drug and alcohol use and EPS in a group of patients with schizophrenia.

Methods

Seventy patients with schizophrenia assessed for drug and alcohol use, global functioning, EPS and suicidality. Chlorpromazine equivalents were correlated to levels of EPS and substance abuse.

Results

Current EPS were found in 65% of the sample despite three‐quarters of the patients receiving second‐generation antipsychotics. An even higher level of patients, 87%, was found to have a history of EPS. A long history of schizophrenia independently predicted presence of any EPS, particularly akathisia, controlling for history of substance abuse which was a non‐significant predictor.

Conclusions

History or current use of alcohol or drug abuse did not predict EPS, except for alcohol abuse at the time of diagnosis which was associated with current akathisia. Length of illness was correlated with EPS, whereas suicidality was not linked to akathisia. Neither chlorpromazine equivalent antipsychotic dose nor whether the patient received first‐generation or second‐generation antipsychotic medication was significantly associated with EPS or substance abuse. Copyright © 2013 John Wiley & Sons, Ltd.
Preparation, characterization, and biological properties of organic–inorganic nanocomposite coatings on titanium substrates prepared by sol–gel
Authors: Catauro Michelina , Bollino Flavia , Papale Ferdinando
Published: March 2013

When surface‐reactive (bioactive) coatings are applied to medical implants by means of the sol–gel dip‐coating technique, the biological proprieties of the surface of the implant can be locally modified to match the properties of the surrounding tissues to provide a firm fixation of the implant. The aim of this study has been to synthesize, via sol–gel, organoinorganic nanoporous materials and to dip‐coat a substrate to use in dental applications. Different systems have been prepared consisting of an inorganic zirconium‐based matrix, in which a biodegradable polymer, the poly‐ε‐caprolactone was incorporated in different percentages. The materials synthesized by the sol–gel process, before gelation, when they were still in sol phase, have been used to coat a titanium grade 4 (Ti‐4) substrate to change its surface biological properties. Thin films have been obtained by means of the dip‐coating technique. A microstructural analysis of the obtained coatings was performed using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy. The biological proprieties have been investigated by means of tests in vitro. The bone‐bonding capability of the nanocomposite films has been evaluated by examining the appearance of apatite on their surface when plunged in a simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma. The examination of apatite formation on the nanocomposites, after immersion in SBF, has been carried out by SEM equipped with energy‐dispersive X‐ray spectroscopy. To evaluate cells–materials interaction, human osteosarcoma cell line (Saos‐2) has been seeded on specimens and cell vitality evaluated by WST‐8 assay. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 392–399, 2014.
RECRUITMENT OF COMMUNITY‐RESIDING YOUTH INTO STUDIES ON AGGRESSION
Authors: Richmond Therese S. , Cheney Rose , Soyfer Liana , Kimmel Rebecca , Raine Adrian
Published: March 2013

Recruitment of community‐based youth into studies is challenging. We examined access issues, minority status, and personal costs of participation for a study of children with aggressive behaviors, designed to identify which ones are at risk for future violent behaviors, to identify protective factors, and to test interventions to reduce aggression. Of 1,038 contacts, 112 declined, 239 could not be re‐contacted, and 124 were ineligible. Three hundred and fifty of 563 scheduled child‐parent dyads completed intake assessment. Most were recruited through targeted mailings (33%) and community flyers (22%), 12% through regional news advertisement, 8% by Craigslist, and 5% through healthcare providers/clinics. Factors contributing to enrollment rates by zip code showed the percentage of Black residents per zip code and targeted mailings positively contributed (Beta = .200 & .419, respectively) and estimated transit travel time negatively contributed (Beta =.299) to enrollment rates (R2 = 0.562). Targeted mailings proved to be the most efficient strategy in successful recruitment.
CONNECTING FOR HEALTH: PLAYING WITH HORSES AS A THERAPEUTIC TOOL
Authors: Maujean Annick , Kendall Elizabeth , Lillan Roquet , Sharp Tony , Pringle Graham
Published: March 2013

This pilot study examined a brief psychological intervention using horses as a therapeutic tool to improve levels of self‐esteem, self‐efficacy, and facilitate the development of life skills in a group of disengaged youths (n = 16). Participants and their case managers were interviewed after completion of the program to explore their responses to the intervention. Interview transcripts were coded to identify participants’ experiences and outcomes. Five themes emerged from these interviews, namely, (a) enjoyment, (b) psychological and social benefits, (c) engagement, (d) transferrable skills, and (e) mechanisms of change. The findings of this study indicate that this type of intervention may provide a viable option for youths who are disengaged from school and/or the community and who have not responded to traditional interventions.
Quantitative zonal differentiation of articular cartilage by microscopic magnetic resonance imaging, polarized light microscopy, and Fourier‐transform infrared imaging
Authors: Lee JI Hyun , Xia Yang
Published: March 2013

This study aimed to synchronize the zonal differentiation of the full‐thickness articular cartilage by three micro‐imaging techniques, namely microscopic magnetic resonance imaging (µMRI), polarized light microscopy (PLM), and Fourier‐transform infrared imaging (FTIRI). Eighteen cartilage‐bone blocks from three canine humeral joints were imaged by: (a) µMRI T2 relaxation at 0° and 55° orientations in a 7 T magnetic field, (b) PLM optical retardation and azimuthal angle, and (c) FTIRI amide I and amide II anisotropies at 0° and 90° polarizations relative to the articular surface. In addition, µMRI T1 relaxation was imaged before and after the tissue being immersed in gadolinium (contrast agent) solution, to calculate the proteoglycan concentration. A set of previously established criteria in cartilage imaging was revised. The new criteria could simultaneously correlate the thicknesses of the three consecutive subtissue zones in articular cartilage among these imaging techniques. Microsc. Res. Tech. 76:625–632, 2013. © 2013 Wiley Periodicals, Inc.
Effect of torrefaction for the pretreatment of rice straw for ethanol production
Authors: Sheikh Md Mominul Islam , Kim Chul‐Hwan , Park Hyeon‐Jin , Kim Sung‐Ho , Kim Gyeong‐Chul , Lee Ji‐Young , Sim Sung‐Woong , Kim Jae Won
Published: March 2013

BACKGROUND

Rice straw is an attractive lignocellulosic material for ethanol production, since it is one of the most abundant renewable resources. It generally has high cellulose and hemicellulose contents that can be readily hydrolysed into sugars for subsequent ethanol fermentation. The pretreatment method plays an important role in increasing the efficiency of enzymatic saccharification, thereby making the whole process economically viable. Torrefaction is an appropriate pretreatment technique for enhancing the enzymatic reaction and subsequent ethanol production.

RESULTS

The effects of two important parameters, i.e. residence time (20, 40 and 60 min) and temperature (160, 180, 200, 220, 240 and 260 °C), were studied under an inert atmosphere. The highest yield of 351 ± 5.49 mg g−1 total sugars was obtained after torrefaction treatment at 220 °C for 40 min, representing a 60.68% increase compared with the untreated sample. Based on ethanol studies conducted on rice straw, this estimated quantity of sugars could produce 150 ± 2.40 mg g−1 ethanol, a 50.67% increase compared with the untreated sample under anaerobic conditions. The fermentation rate was enhanced by adding 0.4 mmol L−1 benzoic acid.

CONCLUSION

The use of this waste material could reduce competition with food materials for ethanol production. It can be considered as an alternative sustainable waste management option. © 2013 Society of Chemical Industry
Carbon Depletion by Plowing and its Restoration by No‐Till Cropping Systems in Oxisols of Subtropical and Tropical Agro‐Ecoregions in Brazil
Authors: de Moraes Sá João Carlos , Séguy Lucien , Tivet Florent , Lal Rattan , Bouzinac Serge , Borszowskei Paulo Rogério , Briedis Clever , dos Santos Josiane Burkner , da Cruz Hartman Daiani , Bertoloni Clayton Giani , Rosa Jadir , Friedrich Theodor
Published: March 2013

The continuous use of plowing for grain production has been the principal cause of soil degradation. This project was formulated on the hypothesis that the intensification of cropping systems by increasing biomass‐C input and its biodiversity under no‐till (NT) drives soil restoration of degraded agro‐ecosystem. The present study conducted at subtropical [Ponta Grossa (PG) site] and tropical regions [Lucas do Rio Verde, MT (LRV) site] in Brazil aimed to (i) assess the impact of the continuous plow‐based conventional tillage (CT) on soil organic carbon (SOC) stock vis‐à‐vis native vegetation (NV) as baseline; (ii) compare SOC balance among CT, NT cropping systems, and NV; and (iii) evaluate the redistribution of SOC stock in soil profile in relation to soil resilience. The continuous CT decreased the SOC stock by 0·58 and 0·67 Mg C ha−1 y−1 in the 0‐ to 20‐cm depth at the PG and LRV sites, respectively, and the rate of SOC sequestration was 0·59 for the PG site and ranged from 0·48 to 1·30 Mg C ha−1 y−1 for the LRV site. The fraction of C input by crop residues converted into SOC stock was ~14·2% at the PG site and ~20·5% at the LRV site. The SOC resilience index ranged from 0·29 to 0·79, and it increased with the increase in the C input among the NT systems and the SOC sequestration rates at the LRV site. These data support the hypothesis that NT cropping systems with high C input have a large potential to reverse the process of soil degradation and SOC decline. Copyright © 2013 John Wiley & Sons, Ltd.
Ethnic‐specific WRN mutations in South Asian Werner syndrome patients: potential founder effect in patients with Indian or Pakistani ancestry
Authors: Saha Bidisha , Lessel Davor , Nampoothiri Sheela , Rao Anuradha S. , Hisama Fuki M. , Peter Dincy , Bennett Chris , Nürnberg Gudrun , Nürnberg Peter , Martin George M. , Kubisch Christian , Oshima Junko
Published: March 2013

Werner syndrome (WS) is a rare autosomal recessive disorder characterized by multiple features consistent with accelerated aging. It is caused by mutations in the WRN gene, which encodes a RecQ type helicase. To date, more than 70 disease‐causing mutations have been reported. While founder mutations and a corresponding relatively high incidence of WS have been reported in Japan and Sardinia, such mutations have not been previously described among patients of South Asian descent. Here, we report two novel WRN mutations in three pedigrees. A homozygous c.561A>G mutation in exon 6 was identified both in a pedigree from Kerala, India and in a British patient of Pakistani ancestry. Although c.561A>G does not alter the corresponding amino acid (p.Lys187), it creates a cryptic splice site resulting in a 98 bp deletion at the mRNA level (r.557_654del98) followed by a frameshift (p.Lys187Trpfs*13). These two cases shared the same haplotype across the WRN gene, and were distinct from another Indian Werner patient with a homozygous stop codon mutation, c.2855 C > A (p.Ser952*), in exon 24. As the Indian population increases and the awareness of WS grows, we anticipate that more cases will be identified with these founder mutations among South Asian WS patients.