bluuebunny/crossref_metadata_2025 huggingface dataset:
Valorização pessoal e a qualidade de vida dos servidores na coordenadoria pedagógica de um Instituto Federal de Educação, Ciência e Tecnologia
Authors: Gomes Fábio Alexandre Pereira Lima da Silva , Raymundo Gislene Miotto Catolino
Published: September 2023

A Coordenadoria Pedagógica nos Institutos Federais desempenha um papel crucial na promoção e integração de alunos, professores e familiares, estabelecendo relações interpessoais saudáveis para aprimorar o processo de ensino e aprendizagem. Este artigo visa identificar as causas das dificuldades de atendimento na Coordenadoria Pedagógica do Instituto Federal de Santa Catarina, campus Joinville, com foco na valorização humana e qualidade de vida dos servidores. A pesquisa, qualitativa e de estudo de caso, coletou dados através de questionários respondidos por doze servidores da Coordenadoria. A análise dos resultados e revisão bibliográfica revelaram: a) o papel da coordenação pedagógica nos Institutos Federais; b) valorização dos servidores; c) perfil dos participantes da pesquisa; d) percepção dos servidores sobre qualidade de vida no trabalho. Os resultados indicaram que reconhecer os perfis dos servidores melhora as condições de trabalho e bem-estar. Os atuais fluxos de resolução de demandas afetam o bem-estar durante o expediente. Conclui-se que incentivar a valorização pessoal dos servidores da Coordenadoria Pedagógica aprimora a produtividade, reduzindo dificuldades de atendimento e melhorando a qualidade de vida no trabalho.
MANAJEMEN IMPLEMENTASI KURIKULUM BAHASA ARAB MODERN DI PONDOK SALAF: FAKTOR PENDUKUNG DAN PENGHAMBAT
Authors: Ahmad Nuruddin
Published: September 2023

The success of the curriculum is influenced by how management is carried out. This study aims to collect data and all information regarding the management of the implementation of the modern Arabic learning curriculum at Pondok Salaf and its supporting and inhibiting factors. The curriculum used in several Islamic boarding schools began to develop, especially in Pondok Tahfidh Manba'ul Qur'an where this research was conducted by combining the two curricula with advantages and disadvantages, giving rise to a new curriculum concept. This study uses a qualitative method. Sources of research data are observation, interviews, and documentation. The results of this study indicate that the management of the implementation of the Modern Arabic learning curriculum at Pondok Salaf still has many deficiencies that must be completed. Some of the supporting factors that can be found are 1) the activeness of the teacher, 2) management control, 3) consequences, and 4) other programs. Some inhibiting factors that can be found are 1) lack of teachers, 2) Ability of administrators, 3) Consequences, and 4) Other programs.
PREPARATION AND IN VITRO CHARACTERIZATION OF LIDOCAINE LOADED ALOE VERA GEL FORMULATION FOR THE TREATMENT OF BURN WOUNDS
Authors: GÜVEN Umay Merve , ÇEVİKELLİ Tilbe , SONGÜLOĞLU Sanem , DEMİRCİ KAYIRAN Serpil
Published: September 2023

Objective: In this study, topically applied in situ gel formulations were aimed to design for the modulation of burns, with the active ingredient lidocaine and the gel gained from the Aloe vera plant. The prepared in situ gels were in the liquid form at the room temperature and gelled at the body temperature and adhered to the wound surface, resulting in higher drug residence time. By improving the characteristic properties of the in situ gels, it is aimed to improve patient compliance by obtaining higher local lidocaine concentration.
Material and Method: In situ gel formulations separated by giving different gel codes were examined with characteristic analyses. Within the scope of these examinations, measurement of gelation temperature, pH measurement, in vitro lidocaine release, viscosity and rheological properties and the texture profile of the formulations were determined.
Result and Discussion: Poloxamer 407 based in situ gels designed for topical treatment containing Aloe vera gel and lidocaine have been shown to increase skin residence time. Among the formulations prepared with different content ratios of the polymers Poloxamer 407, Poloxamer 188, HPMC and CMC, the gels coded F5 and A21 showed acceptable gelation temperature for topical use and sustained lidocaine release for 24 hours. According to these findings, it can be revealed that Poloxamer 407-HPMC based in situ gel formulation may be an effective alternative for topical burn treatment.
How Should Patients with Dementia and Food Refusal Be Managed?
Authors: Ong Lynn , Foong Deborah , Jiang Jeffrey
Published: September 2023

Anorexia of ageing is contributed by physiological changes, comorbidities, medications, and social factors. Food refusal in older adults with dementia is one of the behavioural and psychological symptoms of dementia. Modifying diet texture, fluid consistency, feeding techniques, and environmental factors can assist in overcoming food refusal. This case illustrates the challenges encountered in patients with dementia demonstrating food refusal behaviour, measures that can be taken to optimise their nutrition, and how these challenges may impact their long-term care.
Performance of 420 kV Instrument Transformers under Earthquake
Authors: Gupta Yamini , Babu D. Nagesh , Selvam R. Panneer
Published: September 2023

Seismic performance of substation equipment during past earthquakes is poor. In addition, requirement of electric power during post-earthquake led to an increased focus on the earthquake survivability of substation equipment. Equipment installed in the substation is vulnerable to earthquakes by virtue of its geometry and configuration. Interconnection between equipment further aggravates the problem. Failure of substation equipment results in financial loss and considerable time is required to repair/replace the equipment to restore power supply. Earthquake vibration level can be evaluated based on site/location but predicting time of occurrence of earthquake is not possible. High voltage substation equipment shall be designed for seismic loading. Foundation, anchoring, installation and interconnection between equipment also need to be engineered according to the seismic load based on location of installation of equipment. Seismic qualification of various substation equipment as per National and International standard is performed using tri-axial shake table facility of Earthquake Engineering and Vibration Research Centre. Performance of 420kV instrument transformers under earthquake environment is presented in this paper.
Lifesaving Maneuver In Full Airway Obstruction Caused By Foreign Body Aspiration: Pushing The Foreign Body To The Right Main Bronchus
Authors: Çelenk Merve , Akyüz Oktay Selin , Oktay Mehmet Ali
Published: September 2023

Foreign body aspiration (FBA) is one of the leading causes of accidental death in children. Patients with severe respiratory failure and upper airway obstruction who need resuscitation due to FBA apply to emergency services. In this case report, we present a 22-month-old male patient who applied to the pediatric emergency department due to foreign body aspiration, and whose saturation value increased by providing unilateral lung ventilation by pushing the foreign body from the trachea into the bronchi during intubation for advanced airway
Evaluation of in vitro Antioxidant, Antimicrobial and Cytotoxic Activities of Crude Ethanol Extract and Fractions of Achillea sintenisii Hub. Mor.
Authors: ERUYGUR Nuraniye , ATAŞ Mehmet , TEKİN Mehmet , CEVİK Ozge
Published: September 2023

Objective: The Achillea species have been used to treat various ailments due to its anti-inflammatory, hemostatic, spasmolytic and cholagogue effects in the Turkish traditional medicine. However, there is no biological activity studies on some Achillea species except for the well-knowns. This work aimed to determine the antioxidant, antimicrobial and cytotoxic activities of the crude ethanolic extracts and fractions of Achillea sintenisii using in vitro methods.
Methods: The antioxidant activity was investigated by DPPH (1,1´-diphenyl- 2-picrylhydrazyl), ABTS (2,2´-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging, total phenol and total flavonoid content, and iron chelating methods. Antimicrobial activity evaluated by micro-plate dilution method against five test organisms. Cytotoxicity was determined by MTT method using MCF-7 breast cancer cell line and PC-3 prostate cancer cell line. Apoptosis was also measured by AO/EB staining.
Results: The n-Hexane fractions showed the highest antimicrobial and cytotoxic activities, respectively. Administration of the extracts on the cancer cells showed a concentration dependent inhibition on cell proliferation. The anti-proliferation effect could be via apoptosis and associated with the cell death.
Conclusion: The results showed that the extracts demonstrated antioxidant, antimicrobial, and cytotoxic activity, also supports the claims of traditional usage.
The Relationship Between Academic Performance and Physical Activity, Smart Phone Use and Sleep Quality in University Students
Authors: CEYLAN Ali , DEMİRDEL Ertuğrul
Published: September 2023

Objective: Our study was planned to examine the academic achievement, physical activity, smart phone use and sleep quality of university students.

Methods: Young individuals between the ages of 18-25 studying at a vocational school were included in the study. While recording the demographic information of the participants, individuals were classified as "heavy users" and "light users", taking into account the duration of smartphone use during the day. In addition, the physical activity levels of the individuals were evaluated with the International Physical Activity Questionnaire-Short Form (IPAQ-SF), the smartphone usage level with the Smartphone Addiction Scale-Short Form (SAS-SF), and the sleep quality with the Pittsburg Sleep Quality Index (PSQI).

Results: A total of 424 people, 326 of whom were women, with a mean age of 20.30±1.34 years, participated in the study. It was determined that 70.3% of the participants used smartphones for more than 4 hours a day. It was determined that there was a weak negative correlation between the academic success of the students and their physical activity levels, and that their academic success was not affected by smart phone use and sleep quality. However, it was determined that there was a weak positive correlation between the sleep quality of the students and their smartphone use. It was observed that the physical activity levels of male students were higher, while the academic success and sleep quality of normal education students were better.

Conclusion: We think that active life, adequate and conscious smartphone use and quality sleep habits can affect academic success in university students.
Obesity Awareness Among Elementary School Students: A Controlled Before - After Study
Authors: AKTAŞ Eda , ÇÖVENER ÖZÇELİK Çağrı
Published: September 2023

Objective: Obesity is a metabolic disorder that occurs due to excessive body fat accumulation and can lead to physical and emotional problems. Preventing and treating obesity in childhood and adolescence is crucial. The aim of this study was to evaluate the effectiveness of obesity awareness education provided to fourth-grade elementary school students.

Methods: An experimental study with pretest-posttest control group design was conducted. The study sample consisted of a total of 663 students, 344 students in the experimental group and 319 students in the control group, who attended the fourth grade of two elementary schools in Istanbul and met the inclusion criteria.

Results: The sample included 326 girls (49.2%) and 337 boys (50.8%). The mean (SD) BMI was 18.45 (3.49) in the experimental group and 18.04 (3.00) in the control group. 73% (n = 251) of the students in the experimental group and 77.7% (n = 248) of the students in the control group stated that obesity only made walking/running difficult. There was no difference in obesity awareness scores between the experimental and control groups before the education (p=0.92). However, at 1 week and 1 month after the education, the experimental group had significantly higher scores compared to the control group (p
Development of Floss Made From Local Food In Mamboro Village
Authors: Ansar Ansar , Maudu Rusli , Febriyanti Nuning Sri
Published: September 2023

Food diversification connotes the selection of alternative food ingredients to reduce dependence on one dominant type of food. So far, the dominant type of food in Indonesia is rice. Therefore, food diversification is one of the strategies to achieve food security.

Floss is a food that is generally made from beef. beef floss is often found, but combining products from one food ingredient with other foodstuffs is still rarely found. Combining several food ingredients will increase the nutritional value of a food product.

Organoleptic test design for storability and acceptability of Shredded-Based Local Food with a panel of 25 students.  The data is presented in tabular form accompanied by an explanation of the table in the form of narration. Abon made from local food is acceptable in terms of taste, color, texture and aroma.
Workshop On Making Biscuits Made From Banana Peel Flour (Musa Paradisiaca L)
Authors: Nurjaya Nurjaya , Faisal Elvyrah , Indri Selfiani
Published: September 2023

Indonesia is rich in abundant and diverse local food sources that have the potential to be developed. Various ways to support the national food security program are carried out to maximize the production and consumption of local food sources of non-rice and non-wheat carbohydrates, which are the government's priorities, especially in the field of diversification. The utilization of banana peels can be used as flour which can be made in various processed cakes such as biscuits. The nutritional content of kepok banana peel flour per 100 grams of material is 69.8 g of water, 18.50 g of carbohydrates, 0.32 g of protein, 2.11 g of fat, 715 g of calcium, 117 mg of phosphorus, 1.6 mg of iron, vitamins B 0.12 mg, vitamin C 17.5 mg. This of course can help meet the fiber needs needed by humans. The purpose of this activity is the utilization of banana peel waste to support food security programs. The activity was carried out by providing counseling on food security and demonstrations of making biscuits made from banana peels. This community service increases knowledge in utilizing banana peel waste by being able to make snacks that have nutritional value and can reduce organic waste. It is hoped that biscuits made from banana peel flour can become a favorite snack that is not less competitive and can open up insights for household-scale food production with banana peel raw materials.
Balanced Nutrition Counseling During the Covid 19 Pandemic and Assessment Teenage Nutrition Status
Authors: Kusumawati Dwi Erma , Adhyanti  , Ansar
Published: September 2023

Fase remaja merupakan fase kritis kehidupan dimana pertumbuhan terjadi sangat cepat (tercepat kedua setelah fase bayi) sehingga pemenuhan kebutuhan asupan gizi sangat penting untuk mendukung pertumbuhan. Promosi kesehatan pada remaja menjadi salah satu alternatif solusi untuk meningkatkan derajat kesehatan masyarakat. Program posyandu remaja merupakan suatu wadah yang diharapkan dapat memfasilitasi remaja dalam memahami permasalahan Kesehatan remaja serta memperluas peluang jangkauan akses pelayanan kesehatan remaja. Kondisi pandemi covid 19 berdampak pada kesehatan remaja. Masalah gizi pada remaja yang belum teratasi dengan baik tentu akan berkontribusi pada tingginya angka kejadian penularan virus covid 19 pada remaja. Meningkatkan daya tahan tubuh adalah salah satu kunci agar tidak tertular virus covid 19 yang dilakukan dengan cara makanan makanan bergizi seimbang, cuci tangan dengan air mengalir dan sabun serta rutin berolahraga. Pengabdian masyarakat ini bertujuan mengedukasi gizi seimbang pada remaja di masa pandemi dan penentuan status gizi. Kegiatan dilaksanakan pada hari Selasa tanggal 28 Juni 2022 bertempat mamboro barat dengan peserta sebanyak 27 remaja. Masih terdapat masalah gizi obesitas, berat badan lebih (Overwight), dan kurus pada remaja. Ada peningkatan pengetahuan sebelum dan sesudah penyuluhan. Saran keberlajutan, perlu adanya kegiatan penyuluhan sinergis pada kegiatan Posyandu Remaja.
Utilization Of Gravestone (Pilsbryoconcha Exilis) A Local Food Ingredients Source Of Protein
Authors: Faisal Elvyrah , Bahja  , Stevi Indriastuti Maharadi
Published: September 2023

Food is one of the most important things in human survival and in terms of fulfilling a person's nutrients needed to grow and develop. In accordance with the diversity of resources, culture and local wisdom. Indonesia has a variety of local food sources that produce animal protein in the form of fish, shrimp, shellfish, and others. One source of animal protein that is still rarely known is freshwater clams or Gravestone (Pilsbryoconcha Exilis). People in the North Morowali or Morowali areas usually call the mussel (Pilsbryoconcha Exilis) as meti. One example of the use of this shellfish is making Chips. This Gravestone Chips (Pilsbryoconcha Exilis is made as an alternative to get protein intake. The purpose of this community service is to find out the development of Gravestone chips (Pilsbryoconcha Exilis). The results of community service showed that the results of the assessment before the counseling (pretest) were 27.3% of participants with good knowledge and there was an increase after attending the counseling (posttest) to 91.7%. The conclusion of this community service is that this activity has a good impact on participants in terms of knowledge about protein sources from local food and examples of their processing.
АНТРОПОЛОГИЧЕСКАЯ РЕКОНСТРУКЦИЯ ЛИЦА ПО ЧЕРЕПУ
И ПРОБЛЕМЫ ИДЕНТИФИКАЦИИ
Authors: Рашковская Юлия , Просикова Екатерина , Веселовская Елизавета , Рассказова Анна , Лошак Игорь
Published: September 2023

Описан эксперимент по выявлению наиболее «узнаваемого»
стиля графической реконструкции лица по черепу. Авторы выполнили
восстановление внешности по черепу в трех разных стилях и предложили
респондентам сопоставить каждый из вариантов реконструкции с
фотографиями индивидов, чтобы выбрать, на какой фотографии изображен
тот же человек, что и на реконструкции. В эксперименте принял участие
271 респондент.
ТВЕРСКИЕ КАРЕЛЫ (TVERIN KARIELAZET) КАК ОБЪЕКТ АНТРОПОЛОГИЧЕСКОГО ИЗУЧЕНИЯ: ИСТОРИЯ И ПЕРСПЕКТИВЫ
Authors: Крыков Егор
Published: September 2023

Данная работа посвящена историческому обзору антропологиче-
ских исследований тверских карел. Тверские карелы (самоназвание tverin
karielazet), удаленная от основного этнического массива субэтническая
группа финно-угорского народа, сформировались в XVII в. Планомерное
изучение физического типа карел на территории компактного проживания
в России впервые проведено в 1921–1929 гг. экспедициями ГАИМК и этно-
графического отдела Русского музея п/р Д. А. Золотарёва. Тверские каре-
лы обследованы Верхневолжской этнологической экспедицией 1921–1923
гг. в разных уездах Тверской губернии. Показано, что карелы Карелии и
Верхнего Поволжья антропологически близки к русским тех же регионов
по ряду признаков больше, чем между собой. Книга Д.А. Золотарева «Ка-
релы СССР» 1930 года, анализирующая антропологический состав карел
начала XX в., долгое время оставалась единственной подробной работой
по данной теме. Следующее исследование карел и северных русских уже
по современной расово-морфологической программе проведено в 1950-е
годы экспедициями кафедры этнографии Исторического факультета МГУ
п/р М. В. Витова. Тогда обследовано восемь карельских групп, в том числе
тверские карелы Лихославльского р-на в 1955 г. Цифровые данные опубли-
кованы в книге М. В. Витова «Антропологические данные как источник по
истории колонизации Русского Севера» (1997). Они уточнили сведения о
физическом типе карельского населения как варианта восточнобалтийского
типа. В 2023 г. мы планируем продолжить диахронное изучение тверских
карел, применив современные методические приемы физической антропологии для сбора и обработки материала. В рамках подготовки антрополо-
гической экспедиции на территории Лихославльского р-на Тверской обл.
предлагаем обзор литературных данных по соматологической программе.
Implementation of the International Classification of Functioning, Disability and Health model in cochlear implant recipients: a multi-center prospective follow-up cohort study
Authors: Andries Ellen , Lorens Artur , Skarżyński Piotr Henryk , Skarżyński Henryk , Calvino Miryam , Gavilán Javier , Lassaletta Luis , Tavora-Vieira Dayse , Acharya Aanand , Kurz Anja , Hagen Rudolf , Anderson Ilona , Amann Edda , Van de Heyning Paul , Van Rompaey Vincent , Mertens Griet
Published: September 2023

Introduction

No standard protocol based on a multidisciplinary framework currently exists for the evaluation, follow-up and interpretation of Cochlear Implant (CI) outcomes in clinical routine. Therefore, this study aimed to develop and clinically implement a multidimensional Cochlear Implant (CI) outcome assessment protocol for adult CI users based on the International Classification of Functioning, Disability and Health (ICF).

Methods

An international multidisciplinary core group of CI experts selected the most relevant ICF categories and codes for adult CI users out of the existing ICF core set for hearing loss. A well-known, commonly used instrument or method was identified and assigned to each ICF category along with quantified ICF qualifiers. These qualifiers facilitate the interpretation of CI outcomes by categorizing the outcome on a rating scale between 0 and 4, based on the severity of participants' impairment/restriction/limitation/barrier. The ICF-based CI outcome assessment protocol was applied in clinical routine in a prospective longitudinal multicenter study assessing a consecutive sample of 72 adult CI candidates before and 6 months after implantation. For each relevant ICF category, the participants' improvement, stability or deterioration was specified in a descriptive approach using ICF qualifiers.

Results

Participants either showed improved or stable ICF qualifiers after cochlear implantation across all ICF domains (e.g., Body Functions and Structures, Activities, and Participation and Environmental factors). The ICF qualifiers for environmental sound tolerance (n = 30 [45%]) and vestibular functions (n = 21 [33%]) deteriorated most frequently after implantation. ICF qualifiers for falling (n = 53 [83%]) and dizziness (n = 40 [62%]) remained stable in most participants. Auditory perception-related and communication-related categories generally improved in most participants after cochlear implantation, with 46 to 73% (n = 34 to n = 48) of CI users perceiving an improvement postoperatively.

Conclusion

This study is the first to propose and apply a ready-to-use CI outcome assessment protocol based on the ICF model, which provides a common language and comprehensive assessment protocol for the description and measurement of CI outcomes worldwide. Its straightforward outcome description and rating enables CI outcome interpretation by non-experts, enhancing multidisciplinary communication and knowledge on individual healthcare needs in CI users.
Human endometrium-derived mesenchymal stem/stromal cells application in endometrial-factor induced infertility
Authors: Bausyte Raminta , Vaigauskaite - Mazeikiene Brigita , Borutinskaite Veronika , Valatkaite Elvina , Besusparis Justinas , Valkiuniene Ruta Barbora , Kazenaite Edita , Ramasauskaite Diana , Navakauskiene Ruta
Published: September 2023

Endometrial-factor induced infertility remains one of the most significant pathology among all fertility disorders. Stem cell-based therapy is considered to be the next-generation approach. However, there are still issues about successfully retrieving human endometrium-derived mesenchymal stem/stromal cells (hEnMSCs). Moreover, we need to establish a better understanding of the effect of hEnMSCs on the endometrial recovery and the clinical outcome. According to these challenges we created a multi-step study. Endometrium samples were collected from females undergoing assisted reproductive technology (ART) procedure due to couple infertility. These samples were obtained using an endometrium scratching. The hEnMSCs were isolated from endometrium samples and characterized with flow cytometry analysis. Groups of endometrium injured female mice were established by the mechanical injury to uterine horns and the intraperitoneal chemotherapy. The hEnMSCs suspension was injected to some of the studied female mice at approved time intervals. Histological changes of mice uterine horns were evaluated after Masson’s trichrome original staining, hematoxylin and eosin (H&E) staining. The fertility assessment of mice was performed by counting formed embryo implantation sites (ISs). The expression of fibrosis related genes (Col1a1, Col3a1, Acta2, and CD44) was evaluated by the reverse transcription—quantitative polymerase chain reaction (RT-qPCR). Results showed that endometrium scratching is an effective procedure for mesenchymal stem/stromal cells (MSCs) collection from human endometrium. Isolated hEnMSCs met the criteria for defining MSCs. Moreover, hEnMSCs-based therapy had a demonstrably positive effect on the repair of damaged uterine horns, including a reduction of fibrosis, intensity of inflammatory cells such as lymphocytes and polymorphonuclear cells (PMNs) and the number of apoptotic bodies. The injured mice which recieved hEnMSCs had higher fertility in comparison to the untreated mice. Gene expression was reflected in histology changes and outcomes of conception. In conclusion, hEnMSCs demonstrated a positive impact on endometrium restoration and outcomes of endometrial-factor induced infertility. Further exploration is required in order to continue exploring the multifactorial associations between stem cell therapy, gene expression, endometrial changes and reproductive health, so we can identify individually effective and safe treatment strategies for endometrial-factor induced infertility, which is caused by mechanical effect or chemotherapy, in daily clinical practise.
Green synthesis of Piper nigrum copper-based nanoparticles: in silico study and ADMET analysis to assess their antioxidant, antibacterial, and cytotoxic effects
Authors: Kiranmayee Modumudi , Rajesh Nambi , Vidya Vani M. , Khadri Habeeb , Mohammed Arifullah , Chinni Suresh V. , Ramachawolran Gobinath , Riazunnisa Khateef , Moussa Ashaimaa Y.
Published: September 2023

Nanobiotechnology is a popular branch of science that is gaining interest among scientists and researchers as it allows for the green manufacturing of nanoparticles by employing plants as reducing agents. This method is safe, cheap, reproducible, and eco-friendly. In this study, the therapeutic property of Piper nigrum fruit was mixed with the antibacterial activity of metallic copper to produce copper nanoparticles. The synthesis of copper nanoparticles was indicated by a color change from brown to blue. Physical characterization of Piper nigrum copper nanoparticles (PN-CuNPs) was performed using UV-vis spectroscopy, FT-IR, SEM, EDX, XRD, and Zeta analyzer. PN-CuNPs exhibited potential antioxidant, antibacterial, and cytotoxic activities. PN-CuNPs have shown concentration-dependent, enhanced free radical scavenging activity, reaching maximum values of 92%, 90%, and 86% with DPPH, H2O2, and PMA tests, respectively. The antibacterial zone of inhibition of PN-CuNPs was the highest against Staphylococcus aureus (23 mm) and the lowest against Escherichia coli (10 mm). PN-CuNPs showed 80% in vitro cytotoxicity against MCF-7 breast cancer cell lines. Furthermore, more than 50 components of Piper nigrum extract were selected and subjected to in silico molecular docking using the C-Docker protocol in the binding pockets of glutathione reductase, E. coli DNA gyrase topoisomerase II, and epidermal growth factor receptor (EGFR) tyrosine to discover their druggability. Pipercyclobutanamide A (26), pipernigramide F (32), and pipernigramide G (33) scored the highest Gibbs free energy at 50.489, 51.9306, and 58.615 kcal/mol, respectively. The ADMET/TOPKAT analysis confirmed the favorable pharmacokinetics, pharmacodynamics, and toxicity profiles of the three promising compounds. The present in silico analysis helps us to understand the possible mechanisms behind the antioxidant, antibacterial, and cytotoxic activities of CuNPs and recommends them as implicit inhibitors of selected proteins.
Distinct selectivity inside self-assembled coordination cages
Authors: Liang Yang , Zhou Xiaojuan , Gopi Sreeraj , Wang Rui
Published: September 2023

Supramolecular containers have long been applied to regulate organic reactions with distinct selectivity, owing to their diverse functions such as the ability to pose a guest molecule(s) with a certain orientation and conformation. In this review, we try to illustrate how self-assembled coordination cages could achieve this goal. Two representative cage hosts, namely, self-assembled Pd(II)-ligand octahedral coordination cages ([Pd6L4]12+) and self-assembled Ga(III)-ligand tetrahedral coordination cages ([Ga4L6]12−) are selected as the pilot hosts that this mini review covers. Representative works in this area are presented here in brief.
Giant cells: multiple cells unite to survive
Authors: Hazra Shreyasee , Kalyan Dinda Suman , Kumar Mondal Naba , Hossain Sk Rajjack , Datta Pratyay , Yasmin Mondal Afsana , Malakar Pushkar , Manna Dipak
Published: September 2023

Multinucleated Giant Cells (MGCs) are specialized cells that develop from the fusion of multiple cells, and their presence is commonly observed in human cells during various infections. However, MGC formation is not restricted to infections alone but can also occur through different mechanisms, such as endoreplication and abortive cell cycle. These processes lead to the formation of polyploid cells, eventually resulting in the formation of MGCs. In Entamoeba, a protozoan parasite that causes amoebic dysentery and liver abscesses in humans, the formation of MGCs is a unique phenomenon and not been reported in any other protozoa. This organism is exposed to various hostile environmental conditions, including changes in temperature, pH, and nutrient availability, which can lead to stress and damage to its cells. The formation of MGCs in Entamoeba is thought to be a survival strategy to cope with these adverse conditions. This organism forms MGCs through cell aggregation and fusion in response to osmotic and heat stress. The MGCs in Entamoeba are thought to have increased resistance to various stresses and can survive longer than normal cells under adverse conditions. This increased survival could be due to the presence of multiple nuclei, which could provide redundancy in case of DNA damage or mutations. Additionally, MGCs may play a role in the virulence of Entamoeba as they are found in the inflammatory foci of amoebic liver abscesses and other infections caused by Entamoeba. The presence of MGCs in these infections suggests that they may contribute to the pathogenesis of the disease. Overall, this article offers valuable insights into the intriguing phenomenon of MGC formation in Entamoeba. By unraveling the mechanisms behind this process and examining its implications, researchers can gain a deeper understanding of the complex biology of Entamoeba and potentially identify new targets for therapeutic interventions. The study of MGCs in Entamoeba serves as a gateway to exploring the broader field of cell fusion in various organisms, providing a foundation for future investigations into related cellular processes and their significance in health and disease.
The impact of SARS-Cov-2 infection on the periocular injection pain and hypersensitive reaction to botulinum toxin type A: results from clinical questionnaires
Authors: Liu Xiangyu , Tian Yanli , Jiang Chanyuan , Dong Miao , Li Ming , Sun Hefeng , Han Xuefeng , Li Facheng
Published: September 2023

Background

The COVID-19 pandemic has brought about significant changes in the medical field, yet the use of botulinum toxin type A has remained uninterrupted. Plastic surgeons must carefully consider the timing of administering botulinum toxin type A to patients who have recovered from COVID-19.

Methods

A questionnaire survey was conducted among patients who had contracted and recovered from SARS-CoV-2 within a month. The survey aimed to investigate various indicators in patients who had received botulinum toxin A injections at the same site before and after their infection, including pain scores and allergic reactions and the occurrence of complications.

Results

The pain scores of patients who contracted SARS-CoV-2 infection between 14-21 days post-infection exhibited significant variation from previous injections. However, patients who contracted the infection between 22-28 days post-infection did not exhibit significant variation from previous injections. Furthermore, the incidence of allergic reactions and complications following botulinum toxin injection within one month after contracting the infection did not significantly differ from that observed prior to infection.

Conclusion

Administering botulinum toxin type A three weeks after COVID-19 recovery is a justifiable and comparatively secure approach.
“Heading for Extinction”: the representation of scientific knowledge in Extinction Rebellion's recruitment talks
Authors: Thierry Aaron
Published: September 2023

This study examines how the climate action group Extinction Rebellion represents scientific knowledge in the public presentations used to recruit new members. Using a combination of semi-structured interviews and recordings of the talks and comparing them across four versions, we examine how the talk developed and identify four distinct modes of science communication. This analysis also highlights that many factors shape the mode of science communication employed, with the outcome particularly influenced by the editors' concept of how to best motivate action, as well as changes in the wider communication environment and the evolution of the movement's strategic aims. We note the way in which the modes are expressions of “boundary work” seeking to either include or exclude scientific views the group perceives as either aligning with, or running counter to, their political goals.
Embracing the uncertainty in human–machine collaboration to support clinical decision-making for mental health conditions
Authors: Popat Ram , Ive Julia
Published: September 2023

Two significant obstacles exist preventing the widespread usage of Deep Learning (DL) models for predicting healthcare outcomes in general and mental health conditions in particular. Firstly, DL models do not quantify the uncertainty in their predictions, so clinicians are unsure of which predictions they can trust. Secondly, DL models do not triage, i.e., separate which cases could be best handled by the human or the model. This paper attempts to address these obstacles using Bayesian Deep Learning (BDL), which extends DL probabilistically and allows us to quantify the model’s uncertainty, which we use to improve human–model collaboration. We implement a range of state-of-the-art DL models for Natural Language Processing and apply a range of BDL methods to these models. Taking a step closer to the real-life scenarios of human–AI collaboration, we propose a Referral Learning methodology for the models that make predictions for certain instances while referring the rest of the instances to a human expert for further assessment. The study demonstrates that models can significantly enhance their performance by seeking human assistance in cases where the model exhibits high uncertainty, which is closely linked to misclassifications. Referral Learning offers two options: (1) supporting humans in cases where the model predicts with certainty, and (2) triaging cases where the model evaluated when it had a better chance of being right than the human by evaluating human disagreement. The latter method combines model uncertainty from BDL and human disagreement from multiple annotations, resulting in improved triaging capabilities.
The influence of coal mining subsidence on the movement and deformation of loess slope in the loess gully area of Northern Shaanxi
Authors: Zheng Beibei , Song Shijie , Cheng Xia , Niu Ruilin , Cheng Xing , Ruan Hao , Li Guodong
Published: September 2023

Introduction: How to solve the contradiction between coal mining and soil and water conservation is a key scientific problem to realize ecological environment protection and high-quality development in the middle reaches of the Yellow River.

Methods: Using FLAC3D numerical simulation experiment method, the influence of loess slope surface shape and coal seam overburden structure coupling on slope movement and deformation is studied.

Results: Under any surface slope shape, the average slope subsidence coefficient (q slope average) increases with the increase of sand layer coefficient after coal mining subsidence. When the sand layer coefficient is less than 0.71, the q slope average increases rapidly, with an increase of more than 2.86%, and when the sand layer coefficient is greater than 0.71, the q slope average tends to be stable. Under any surface slope shape, the q slope average decreases with the increase of sand-mud ratio. When the overburden structure characteristics of any coal seam and the natural slope of the surface slope are less than or equal to 5°, the q slope average of the convex slope is the largest, and the q slope average of the four slope types is ranked as follows: convex slope > straight slope ≈ composite slope > concave slope; When the structural characteristics of overlying strata in any coal seam and the natural slope of surface slope are more than 5°, the q slope average of concave slope is the largest, and the q slope average of four slope types is in the order of concave slope > straight slope ≈ composite slope > convex slope. With the increase of the natural slope of the surface slope, the q slope average first decreases and then increases, and the inflection point is 15°. The influence law of loess slope surface morphology and coal seam overburden structure on the average horizontal movement of slope surface is similar to that of average subsidence of slope surface.

Discussion: The results can provide scientific basis for surface movement and deformation and soil and water conservation in the mining subsidence area of northern Shaanxi in the middle reaches of the Yellow River Basin in China.
Economic impact and risk analysis of integrating sustainable aviation fuels into refineries
Authors: Carlson Nicholas A. , Talmadge Michael S. , Singh Avantika , Tao Ling , Davis Ryan
Published: September 2023

The growth of the aviation industry coupled with its dependence on energy dense, liquid fuels has brought sustainable aviation fuel (SAF) research to the forefront of the biofuels community. Petroleum refineries will need to decide how to satisfy the projected increase in jet fuel demand with either capital investments to debottleneck current operations or by integrating bio-blendstocks. This work seeks to compare jet production strategies on a risk-adjusted, economic performance basis using Monte-Carlo simulation and refinery optimization models. Additionally, incentive structures aiming to de-risk initial SAF production from the refiner’s perspective are explored. Results show that market sensitive incentives can reduce the financial risks associated with producing SAFs and deliver marginal abatement costs ranging between 136-182 $/Ton-CO2e.
Technology-driven energy revolution: the impact of digital technology on energy efficiency and its mechanism
Authors: Wu Hui , Han Mengyu , Shen Yang
Published: September 2023

Introduction: Improving energy efficiency is significant for achieving carbon emission reduction and promoting the transformation of green economic development. In the sustainable development framework set out in the 2030 Agenda for Sustainable Development, Goal 7.3 explicitly aims to double the global rate of energy efficiency improvement by 2030. The rapid development of digital technology, along with its universality and penetrative characteristics, has provide a feasible solution for improving energy efficiency and environmental conditions. However, the theoretical understanding of the impact and underlying logic of digital technology on energy efficiency remains unclear.

Methods: Based on the panel data of 30 provinces in China from 2006 to 2021, this paper adopts econometric methods, including two-way fixed effect, instrumental variable method, and Driscoll-Kraay standard error. It investigates the influence of digital technology on energy efficiency and its internal mechanism from single factor and all factor levels.

Result: The results show that Digital technology, represented by industrial robots, significantly improves energy efficiency, whether measured by the energy consumption intensity of GDP or the total-factor energy efficiency estimated using the SBM-GML model. The results still hold even after conducting endogeneity tests and robustness tests. Digital technology can improve energy efficiency by increasing virtual industrial agglomeration and promoting outward foreign direct investment.

Discussion: In addition to promoting the theoretical understanding of the impact of digital technology on energy efficiency and exploring its mechanism, this paper also provides empirical evidence for policy makers and enterprises to formulate effective measures and strategies to improve energy efficiency under the background of digital economy.
Master–slave game-based optimal scheduling of community-integrated energy system by considering incentives for peak-shaving and ladder-type carbon trading
Authors: Dai Fengzhe , Jiang Fei , Chen Lei , Wu Yongfei , Xiao Changlin
Published: September 2023

To alleviate the challenges posed by high energy consumption, significant carbon emissions, and conflicting interests among multiple parties in a community-level microgrid, the authors of this study propose a master–slave game-based optimal scheduling strategy for a community-integrated energy system (CIES). First, we analyze the decision variables and revenue-related objectives of each stakeholder in the CIES, and use the results to construct a framework of implementation. Second, we develop a model to incentivize peak regulation and a ladder-type carbon trading model that consider the correlation between the load owing to residential consumers, the load on the regional grid, and the sources of carbon emissions. Third, we propose a master–slave game-based mechanism of interaction and a decision-making model for each party to the game, and show that it has a Stackelberg equilibrium solution by combining genetic algorithms and quadratic programming. The results of evaluations showed that compared with an optimization strategy that considers only the master–slave game, the proposed strategy increased the consumption surplus of the user aggregator by 13.65%, the revenue of the community energy operator by 7.95%, increased the revenue of the energy storage operator, reduced CO2 emissions by 6.10%, and adequately responded to peak-cutting and valley-filling by the power grid company.
Enhancing the resilience of the power system to accommodate the construction of the new power system: key technologies and challenges
Authors: Zhou Shichao , Li Yifan , Jiang Chuanwen , Xiong Zhan , Zhang Jihang , Wang Lingling
Published: September 2023

The increasingly frequent extreme events pose a serious threat to the resilience of the power system. At the same time, the power grid is transforming into a new type of clean and low-carbon power system due to severe environmental issues. The system shows strong randomness with a high proportion of renewable energy, which has increased the difficulty of maintaining the safe and stable operation of the power system. Therefore, it is urgent to improve the resilience of the new power system. This paper first elaborates on the concept of power system resilience, listing the characteristics of new power systems and their impact on grid resilience. Secondly, the evaluation methods for resilient power grids are classified into two categories, and measures to improve the resilience of the new power system are reviewed from various stages of disasters. Then, the critical technologies for improving the resilience of the new power system are summarized. Finally, the prospective research directions for new power system resilience enhancement are expounded.
Variations of soil properties and soil surface loss after fire in rotational shifting cultivation in Northern Thailand
Authors: Arunrat Noppol , Sereenonchai Sukanya , Kongsurakan Praeploy , Yuttitham Monthira , Hatano Ryusuke
Published: September 2023

Since fire is still necessary for rotational shifting cultivation (RSC), the vertical distribution and slope effect on soil properties and soil surface loss after a fire remain unclear. To address these research gaps, the study aims to achieve the following objectives: 1) investigating post-fire soil properties and soil surface loss in RSC, and 2) assessing the vertical distribution and slope effect on soil properties and soil surface loss in RSC. Soil samples were collected from two stages of RSC: 6 years (RSC-6Y) and 12 years (RSC-12Y), located in Chiang Mai Province, Northern Thailand. A continuous 15-year left fallow field (CF-15Y) was used as the reference site. Soil samples were collected from the upper, middle, and lower slopes at depths of 0–5, 5–10, 10–20, and 20–30 cm at five different time points: before burning, 5 min, 3 months, 6 months, and 9 months post-fire. The results indicated that older fallow fields had a tendency to accumulate more soil organic carbon (SOC) and soil organic nitrogen (STN). The color of the ash was altered by the fire, resulting in dark reddish-brown ash with higher levels of pH, organic matter (OM), electrical conductivity, total nitrogen, and soil nutrients when compared to gray and white ashes. The combustion of OM during the fire was found to release soil nutrients, which could explain the increase after burning. SOC stock increased at deeper layers (5–10 cm) with higher values than pre-burning levels, especially at lower slope positions, while STN stock decreased at the surface soil post-fire but increased in deeper layers at all slope positions. The average soil surface loss ranged from 1.6 to 3.1 cm, with the highest loss observed 9 months after the fire (during the rainy season) at the upper slope. In terms of the impact of slope on soil properties following the fire event, our study indicated a significant correlation between lower slopes and variables including SOC, STN, electrical conductivity, nitrate–nitrogen (NO3-N), ammonium nitrogen (NH4-N), exchangeable calcium, and exchangeable magnesium. Further study is required to investigate and develop appropriate post-fire management strategies to effectively reduce nutrient loss and minimize soil surface erosion.