bluuebunny/crossref_metadata_2025 huggingface dataset:
Allosteric mechanisms underlying the adaptive increase in hemoglobin-oxygen affinity of the bar-headed goose
Authors: Jendroszek Agnieszka , Malte Hans , Overgaard Cathrine B. , Beedholm Kristian , Natarajan Chandrasekhar , Weber Roy E. , Storz Jay F. , Fago Angela
Published: July 2018

The high blood-O2 affinity of the bar-headed goose (Anser indicus) is an integral component of the biochemical and physiological adaptations that allow this hypoxia-tolerant species to undertake migratory flights over the Himalayas. The high blood-O2 affinity of this species was originally attributed to a single amino acid substitution of the major hemoglobin (Hb) isoform, HbA, which was thought to destabilize the low-affinity T-state, thereby shifting the T-R allosteric equilibrium towards the high-affinity R-state. Surprisingly, this mechanistic hypothesis has never been addressed using native proteins purified from blood. Here, we report a detailed analysis of O2 equilibria and kinetics of native major HbA and minor HbD isoforms from bar-headed goose and greylag goose (Anser anser), a strictly lowland species, to identify and characterize the mechanistic basis for the adaptive change in Hb function. We find that HbA and HbD of bar-headed goose have consistently higher O2 affinities than those of the greylag goose. The corresponding Hb isoforms of the two species are equally responsive to physiological allosteric cofactors and have similar Bohr effects. Thermodynamic analyses of O2 equilibrium curves according to the two-state MWC model revealed higher R-state O2 affinities in the bar-headed goose Hbs, associated with lower O2 dissociation rates, compared to the greylag goose. Conversely, the T-state was not destabilized and the T-R allosteric equilibrium was unaltered in bar-headed goose Hbs. The physiological implication of these results is that increased R-state affinity allows for enhanced O2 saturation in the lungs during hypoxia, but without impairing O2 delivery to tissues.
ИЗУЧЕНИЕ СЕЛЕКЦИОННЫХ ЛИНИЙ САХАРНОГО СОРГО ПО КОМПЛЕКСУ ПРИЗНАКОВ В УСЛОВИЯХ НИЖНЕГО ПОВОЛЖЬЯ
Authors: Vertikova Elena Aleksandrovna , Kuznetsova Anastasia Nikolaevna
Published: July 2018

Расширение площадей под посев сахарного сорго в Нижнем Поволжье сдерживается отсутствием сортов и гибридов, хорошо адаптированных к условиям региона. С целью изучения исходного материала для создания высокопродуктивных конкурентоспособных сортов в течение трёх лет проводили комплексную оценку 85 селекционных линий сахарного сорго. В качестве стандарта использовали районированный сорт Волжское 51.В результате проведенных исследований установили, что селекционные линии сахарного сорго Л-16, Л-25 и Л-42 можно выделить как скороспелые. Линии Л-84 и Л-115 имели высоту растения в среднем на 12,5% выше, чем сорт Волжское 51. По содержанию жира в зеленой массе селекционные линии достоверно не отличались от сорта-стандарта, за исключением линии Л-8 и Л-115, которые уступили сорту Волжское 51. Линии Л-3, Л-5, Л-8, Л-84 достоверно превысили сорт-стандарт Волжское 51 по процентному содержанию сахара в соке в фазу выметывания.По урожайности зеленой массы линии сахарного сорго Л-3, Л-13, Л-26, Л-60, Л-84, Л-109, Л-115, Л-1106 превысили сорт-стандарт на 16,5-36,4%. По урожайности сухого вещества только линии Л-23 и Л-109 значимо превысили сорт Волжское 51 в среднем на 26,6%. Селекционная линия Л-1898/2 имела значение признака «масса 1000 зерен» на 13,4% выше, чем сорт-стандарт. Все изучаемые линии по урожайности зерна превысили сорт-стандарт в среднем на 50,7%, за исключением линии Л-25, которая не отличалась от стандарта.Таким образом, по результатам научных исследований выявили перспективные линии, которые существенно превысили сорт-стандарт Волжское 51 по комплексу хозяйственно-ценных признаков и свойств. Селекционные линии сахарного сорго: Л-109, Л-1106, Л-1327, Л-1898/2 и Л-84 рекомендованы для дальнейшего испытания. Лучшие селекционные линии целесообразно включить в скрещивания для получения гибридов зернового и кормового сорго.
Important Adjustments to the Law on Countering the Legalization of Criminal Proceeds
Authors: Смирнов Е. , Smirnov E.
Published: July 2018

Amendments to the current Federal Law of August 7, 2001, No. 115-FZ "On combating the legalization (laundering) of proceeds from crime and financing of terrorism" by the laws of April 23, 2018, No. 90-FZ and No. 112-FZ, will allow Russia to significantly improve the effectiveness of measures aimed at financing terrorism and the proliferation of weapons of mass destruction.
Economic and Social Factors of the Economic Subjects Development on the Meso-Level
Authors: Аврашков Лев , Avrashkov Lyev , Графов Андрей , Grafov Andrey , Графова Галина , Grafova Galina , Шахватова С. , Shakhvatova S.
Published: July 2018

In article the economic and social factors of development of regions on an example of Lipetsk Region are considered.
Prospective Directions of Development of Social Policy in the Armed Forces of the Russian Federation
Authors: Шепилов С. , Shepilov S. , Маличенко И. , Malichenko I.
Published: July 2018

The implementation of full-scale social programs for national companies is their voluntary expression of will, while the availability of military social work is a compulsory activity in the armed forces of the Russian Federation. In the most general form, military social work is an activity to implement the socioeconomic rights and privileges of servicemen established by the legislation and to ensure, on this basis, their social protection. In connection with the continuous reform of the military system, there is an increasing number of issues of social guarantees and compensations that are not regulated in the legal, organizational and economic aspects, which reduces the attractiveness of the soldier’s profession and increases staff turnover, and, in strategic terms, may aff ect the defense capacity of the country as a whole. In this regard, the issues of improving military social work, the implementation of benefi ts and compensation, social activities aimed at retaining servicemen and their development, are very important and relevant.
The Elitarian Strategy of Professional Formation of Engineers with Hearing impairments
Authors: Авдеева А. , Avdeeva Anna , Емельянов В. , Emel'yanov V. , Новиков П. , Novikov P.
Published: July 2018

The article is about the actual problem of professional development of persons with hearing impairments. Based on the qualitative research method — biographical interview, the research revealed the characteristics of elite strategies of engineer professional development with hearing impairments. The elite strategy is presented as a dynamic system of professional orientation of the personality, who is aimed at deliberate change and design of his/her live in the context of its professionalization and development of a professional future. The paper identifi es and examines the main personal factors that infl uence on the process of forming the competence of an elite specialist with hearing impairments and the versatility of his/her professional activities. Due to the formation of operational and tactical psychological characteristics that the elite scenario of personal and professional development for hearing impaired engineers is realized. The research has the conclusion about the impact of labor market requirements, educational and professional environment on the formation and implementation of the elite strategies of professional formation of specialists with hearing impairments.
Research Project as an Innovative Method of Forming the Professional Competencies of Future HR-Managers (15-Years Experience of the Personnel Management Department of the Siberian Institute of Management)
Authors: Черняк Т. , Chernyak T. , Бадашкова А. , Badashkova A. , Штоп А. , Shtop A.
Published: July 2018

The article presents the results of the 15-years experience of the project activity of the Personnel Management Department of the Siberian Institute of Management on the implementation of numerous research projects on the solution of topical problems for the university and society. This activity is carriedout by teams, which include teachers and students of the department. The author and the head of all the projects described briefly presented approaches, principles, technologies that allow to harmoniously include project activities in the process of training future HR managers. The author highlights the peculiarities of the project activity as a method of training HR managers and cites the results of teaching students and graduates how to use it successfully. The article also presents the results of the latest research project aimed at conducting vocational guidance work with 1st year students of the Faculty of State and Municipal Administration of the University.
The carer-related knowledge exchange network (CAREN): enhancing the relationship between research and evidence and policy and practice
Authors: Larkin Mary , Milne Alisoun
Published: July 2018

Background:

Although there is now an extensive international body of research and evidence about care and carers it is fragmented and disparate. Without synthesis, organisation and accessibility it cannot effectively inform and improve policy and practice with carers.

Key points for discussion:

This paper makes the case for an accessible carer-related research and evidence resource for stakeholders in carer-related domains across policy, practice, research to address this systemic deficit in the carers field. The Carer-related Knowledge Exchange Network (CAREN) has recently been established in recognition of this case. This timely resource is a freely accessible knowledge exchange network that provides relevant stakeholders (for example, carers, commissioners, policymakers, practitioners, employers, third sector organisations, researchers and research funders) with access to a regularly updated and coherent database of carer-related research and evidence; offers interactive opportunities to exchange and generate knowledge; facilitates links and information sharing; and disseminates innovative practice, interventions and services. CAREN’s development, dimensions and functionality are outlined. In addition, the paper identifies and explores the challenges of sustaining CAREN and its further development – namely long-term funding and ensuring that it meets the needs of its many and diverse users.

Conclusions and implications:

It is anticipated that CAREN will make a significant contribution to research, policy development and service and practice improvement with carers, and will enhance the effectiveness of its stakeholders’ activities. The realisation of CAREN’s potential will ensure that it can, and continues to, make a significant, sustained and cost-effective contribution to addressing a critical global issue of the 21st century.
Brokering research in science education policy implementation: the case of a professional association
Authors: Hopkins Megan , Wiley Kathryn E , Penuel William R , Farrell Caitlin C
Published: July 2018

Recent scholarship suggests that research use is an interactive, social phenomenon, and that brokers play important roles in facilitating the exchange of research evidence. We add to this body of literature by exploring the role of brokers in the exchange of research evidence among state education agency leaders involved in K–12 science education policy implementation in the United States. We focus our study on the lead professional association for state science policymakers, the Council of State Science Supervisors (CSSS), because professional associations are the most prominent source of research for state and local education leaders, and are important for supporting the use of research evidence and policy implementation. Our findings, based on analysis of social network survey data, highlight the complex brokering roles CSSS members, and especially leaders in the association, played. These brokers not only enabled association members’ access to diverse sources of research, but also facilitated between-state research exchanges. Our findings have implications for research and theory on brokering, and they point to the importance of professional associations for facilitating access to research to support education policy implementation.
ANALYSIS OF REMEDIAL ACTIONS DESIGNED TO STABILIZE A HIGHWAY CUT IN A LANDSLIDE AREA
Authors: Turček Peter , Šúl'ovská Monika , Kopecký Miloslav , Panuška Jakub
Published: July 2018

The Carpathian flysch is widely recognized as a geological environment prone to slope movements. This fragility in such an environment is due to its complicated geological and hydrogeological conditions. Weakened slip surfaces (developed in clay like material), in combination with present or past tectonic activity and difficult hydrogeological conditions with aquifers under pressure, are the main causes of slope movements. The article proposes to analyze the design of remedial action in a landslide area near Žilina. Slip surfaces and water conditions are assumed regarding present geotechnical monitoring. Deep cut with two rows of pile walls is analyzed by the limit equilibrium method and finite element analysis. Interaction between two walls and the effect of an amount of volume of sliding mass on resultant earth pressures and anchor forces were studied. The results from finite element analysis are compared with analytical calculations and the differences are discussed.
CALIBRATION OF INPUT PARAMETER VALUES FOR AN ADVANCED MATERIAL MODEL OF SPRAYED CONCRETE
Authors: Závacký Martin , Chalmovský Juraj , Miča Lumír , Bílek Petr
Published: July 2018

The paper briefly presents an advanced material model for shotcrete involving many aspects of the actual behavior of concrete. However, the contribution is focused on determination and calibration of selected input parameter values for practical use of the model in structural analysis. Two cross sections of different geological conditions were chosen from a utility tunnel in Brno in order to obtain sprayed concrete samples. The laboratory tests conducted are described and then compared with results from numerical approximations.
Discriminación laboral en la industria azucarera dominicana
Authors: Revuelta Guerrero Laura
Published: July 2018

Los dueños de los bateyes azucareros en República Dominicana muestran poco interés a la hora de proteger laboralmente a los haitianos que trabajan en sus plantaciones, cuyas familias apenas tienen cubiertas las necesidades básicas de alimentación, salud y vivienda. Mediante una mayor difusión de los instrumentos jurídicos disponibles según el sistema laboral, es posible mejorar la situación e incrementar las demandas judiciales contra las violaciones de derechos cometidas por los consorcios azucareros. Para ello, es necesario realizar un análisis de las violaciones laborales contra los trabajadores haitianos en los bateyes y buscar medidas jurídicas adecuadas para proteger sus derechos y eliminar una discriminación histórica basada en las diferencias étnicas y culturales entre dominicanos y haitianos.
Comparación de cuatro métodos de evaluación visual del riesgo de árboles urbanos
Authors: Ponce-Donoso Mauricio , Vallejos-Barra Óscar , Reyes de la Barra Jorge , Daniluk-Mosquera Gustavo , Coelho Duarte Ana Paula
Published: July 2018

Cuatro métodos de evaluación visual del riesgo se aplicaron en 30 árboles urbanos con niveles de riesgo en la ciudad de Talca (Chile). Los métodos utilizados fueron: “Avaliação de árvores de risco na arborização de vias públicas de Nova Olímpia” (método Sampaio), “Internation Society of Arboriculture (ISA) Matheny y Clark” (método ISA[A]), “Best Management Practice BMP/ISA” (método ISA[B]) y “Urban tree risk management USDA Forest Service” (método USF). Los resultados fueron estandarizados para su análisis estadístico, se encontraron diferencias significativas y variaciones en los métodos al aplicar el test no paramétrico de Kruskal-Wallis y de Duncan. Se conformaron tres grupos: los métodos Sampaio y USF, que presentaron evaluaciones con riesgo muy alto y alto, respectivamente; el segundo, conformado por USF e ISA(A), presentó evaluaciones de alto a medio riesgo; mientras que un tercer grupo lo conformó ISA(B), con evaluaciones de riesgo bajo. Ya que la ciudad de Talca no cuenta con una metodología propia, se sugiere usar en el área mediterránea de Chile el método ISA(A) o USF, ya que fueron los métodos que presentaron una mejor adecuación a las condiciones locales.
Evaluación del densificado de la madera de Gyrocarpus americanus Jacq. en su densidad y módulo de elasticidad
Authors: Sotomayor-Castellanos Javier-Ramón
Published: July 2018

El objetivo de la investigación fue densificar madera de G. americanus y evaluar el efecto del tratamiento en la densidad y en el módulo de elasticidad. Inicialmente, la madera se hidrató en agua, durante 72 h y con temperatura de 20 °C. Posteriormente, las probetas se suavizaron durante 4 h en agua caliente con temperatura de 93,5 °C. A continuación, se prensaron las probetas con un dispositivo fabricado especialmente para la investigación. La estrategia de investigación consistió en determinar la densidad y realizar pruebas de flexión estática antes y después del tratamiento. Los coeficientes de compresión y de densificado fueron evaluados después del tratamiento. Se prepararon 32 probetas normalizadas y se realizaron pruebas de flexión estática antes y después del densificado. Para los resultados antes y después del densificado se realizaron pruebas de diferencias de medias para muestras independientes. Se calcularon las regresiones entre los valores del módulo de elasticidad como variable dependiente en función de la variable independiente densidad. El coeficiente de compresión fue de 56,3% y el coeficiente de densificado fue de 50,3%. Después del tratamiento la densidad de G. americanus aumentó 102% y su módulo de elasticidad se incrementó en 113%. Los índices de densificado, elástico y de calidad confirmaron que el tratamiento de densificado higro-termo-mecánico produjo buenos resultados para madera de baja densidad.
Peran Kota Kecil Dalam Perkembangan Wilayah Pada Koridor Jalan Regional Semarang - Yogyakarta
Authors: Hidayati Solikhah Retno
Published: July 2018

The small towns development are becoming an important issue in regional development. They should be able to hold their role as a service center for their upper region and hinterland. It is no exception in Joglosemar corridor.Yogyakarta, Solo, and Semarang, has now been developing as economic center in Java. The role of small towns among them has been decreased because of the big city primacy. This study aim to identify how the small towns hold their role in Semarang-Yogyakarta corridor. The role are viewed from spatial and economic aspect. The indicator of spatial aspect are urban primacy (Zipf’s rank-size rule), polarization (population growth), and service center (centrality index). The economic indicators are regional disparity (Williamson index), economic base (LQ), and economic performance (shift and share). The regional area will be studied from two point of view, they are micro (among small towns and to the hinterland) and macro (to the kabupaten and province).
Penerapan Kebijakan Pembangunan Berkelanjutan di Lingkungan Kampus (Studi Perbandingan Antara Kampus Tembalang Universitas Diponegoro dan Kampus Tertre Universitas Nantes)
Authors: Fatmawati Safrida , Syahbana Joesron Alie
Published: July 2018

City is highly vulnerable to the impacts of climate change because of the large population, the intensive usage of infrastructure and a lot of economic activities. In addition, lifestyle and activity of urban communities, which neglect the impact of energy consumption, tend to increase the concentration of greenhouse gas involved in global warming. Improving the environment and the quality of life become the responsibility of all stakeholders, including the higher education institutions. They are the ones who have the contribution to conserve the environment. Sustainable Campus is a concept that began to develop in the world as a response to the environmental degradation which is integrated into the campus policy. This study proposes to compare the sustainable development policy within the Tertre campus, University of Nantes-France and Tembalang campus, Diponegoro University-Semarang, Indonesia. The material of this study was constituted through the interviews with the main stakeholders, as the key personnel in the field of sustainable development. In summary, we can conclude that the best sustainable development policy in the campus must be integrated into the environmental management, the improvement of the quality of life of the university community, and the strengthening of the economy, as well as engage in partnerships with all the stakeholders.
Pengaruh Kualitas Ruang Terbuka Publik Terhadap Ekspektasi Pengguna di Taman Alun-alun Kapuas, Kota Pontianak
Authors: Awtayuda Adly
Published: July 2018

The open space area is a place of social interaction, such as Taman Alun-alun Kapuas in Pontianak. The objective of this study is to asses the effect of the quality of public open space in Pontianak against the usesrs’ expectations. The study using quantitative method by observation, interview, and distributing the questionnaire. The respondents are the users in the location that determined based on probability sampling techniques. The analysis of qualitative descriptive is used to assess the quality based on the facts in the location. The users’ expectation is analyzed by multiple regression analysis with 5 (five) variables: comfort variable (climatology and facilities); relaxation variable (separator ways, ornament, safety); involvement of passive variable (observation, landscape and natural elements); active involvement variable (ease of doing activities, space of communication, event, and playground); as well as variable discovery (characteristic of the area). The result of this research shows that: the name of Taman Alun-alun Kapuas doesn’t have any relevance with the Alun-alun concept in Java. The high temperature of Pontianak causing many users visit Taman Alun-alun Kapuas in the evening which tends to be a passive activities; there are six indicators which has met the expectations of users: the separator ways, landscape of garden, the observation, freedom of movement, space of communication, and characteristic of areas.; the street vendors in Alun-alun Kapuas has the positive and negative impacts for the users.
Pembangunan Jalan Lingkar Utara dan Perubahan Bentuk dan Struktur Ruang Kota Magetan
Authors: Setiono Dwi Cahyo
Published: July 2018

Magetan Regency Government built north-ring-road in order to alleviate traffic congestion in urban center area. However, the ring-road attracted people to utilize the surrounding area. The area utilization was estimated influencing the form and the structure of Magetan Urban Area. In this respect, this research is aimed to explain the relationship between north-ring road development and the change of form and spatial structure of Magetan Urban Area by using a quantitative approach and a descriptive method in its practice. As the result, the form of Magetan Urban area is compact-square with linear form in the several parts of the urban area. The structure of Magetan Urban Area is sectoral which characterized by the main activity in urban center and swept away following the main road. The development in the periphery area was caused by the increase of activities in urban center. However, the development did not change the urban form, but it contributed to the larger size of the urban form. The development of north-ring road only impacted to the development in the several villages surrounded the road, so it did not change the form and the structure of Magetan Urban Area directly.
Diversifikasi Produk Wisata Sebagai Strategi Pengembangan Daya Saing Wisata Kota Batu
Authors: Sukmaratri Myrna , Damayanti Maya
Published: July 2018

Although it is a new city, the economic growth of Batu City quite rapidly, especially in the tourism sector. The variety of tourism potential bring tourism sector of Batu City become competitive in provincial even national level. However, along the friction of tour base, there are indication relate of tourist saturation in Batu City. It was shown from decrease in number of tourists in the year 2009-2012 with an average of 13% annually. In addition, the rapid development of tourism in Batu City suspected caused some negative impact on the environment. Therefore, efforts to build the tourism sector in Batu City forward has been duly implementing the concept of sustainable tourism, which one of them is by diversification of tourism products. Diversification of tourism products divided into two, namely destinations and attractions. To diversify destinations Batu City is directed to build the tourist market in corridor Diponegoro and Gajah Mada street around Alun-alun Batu City. Meanwhile, the diversification of tourism products for the natural attractions is directed into the development of alternative tourism with travel packages. In artificial attractions, besides the addition of themed rides, managers can diversify tourist attraction by adding a cultural event such as dances at certain hours. Besides that, diversification of tourism products can be done with the addition and improvement of tourism facilities as well as increased accessibility. It can be directed by a central parking and tour transportation as well as the construction of new access by railway from Abdurrahman Saleh Airport to Batu City passing through Malang City.
Pola Perkembangan Penggunaan Lahan Dan Struktur Ruang Di Sekitar Wilayah Eskploitasi Minyak Bumi Di Kota Duri
Authors: Sandri Dian , Rudiarto Iwan
Published: July 2018

City’s development influenced by its natural resource, petroleum is one of them. Petroleum exploration and production activities become the trigger of city’s development which is accompanied by infrastructure and facilities provision, such as transportation access toward petroleum field location. It also provokes the migration activity where people come to gain new opportunity and better life, so it creates new population concentration in those areas. Petroleum industry started with land clearing which is usually by reusing land function. Land use in particular area related with population growth and the activity, the more population figures and their activities increase, it will affect the portion of land use development. In order to response this issue, a research which aim to identify the urban structure and land use development in the petroleum exploitation area is needed, with the research location in Duri, Bengkalis, Riau Province, by considering the periods from 1995 to 2015. This research is using a quantitative method, and supported by identification, comparative, descriptive analysis. While to describe the development of existing condition in the research location, it use GIS software. Comprehensive analysis is done to acknowledge the urban structure and land use development in the exploitation area in Duri. The result of this research are land use development in periods from 1995 to 2015 are affected petroleum field location to urban structure growth in Duri, built up area growth 913.74 Ha in 1995 to 1,583.42 Ha in 2005, and 1,962.02 Ha in 2015. Firstly, built up area growth in along the main transport lines. But over time, towards the development of the spatial structure leads to the east near the Duri oil field and to the north close to oil fields Sebangar in 2005. In 2015 the development of the urban structure began to turn towards the west and south, where the area close to petroleum field location Petani, Pematang and Rangau.
Kajian Siklus Urbanisasi Pada Wilayah Pinggiran Kota Semarang (Studi Kasus: Kecamatan Mijen)
Authors: Nuzullia Laella , Setyono Jawoto Sih
Published: July 2018

Mijen District as a peripheral area of Semarang has been urbanizing based on population growth and land development in the period 1993 – 2015. One of urbanization problems in Mijen district as peripheral area is land use change and increasing population, which caused by BSB new town development. Identification of urbanization stages in the peripheral area is expected as consideration for government to manage regional development effectively and efficiently. This research uses an urbanization cycle approach by Van Den Berg as a conceptual theory to identify the urbanization stages. In addition, the land development and its linkage with the population growth are also used to identify emerging problems, so that the government reduces its impact. The research shows Mijen District runs into the stage of urbanization, suburbanization, desurbanization/ counterurbanization and the absolute phase of decentralization in the period 1993 – 2015. Most of sub-districts in Mijen have sprawl characteristics which the land development of each sub-district is greater than population growth, so it indicates that the land usage is less. Otherwise,  Polaman, Jatisari, Mijen and Wonolopo have densification characters which each population growth is greater than the land development and  indicates that the lands are used effectively and efficiently.
Perilaku Sadar Lingkungan Pemukim Bantaran Sungai Jelai, Kabupaten Sukamara
Authors: Purwanto Nova
Published: July 2018

Terbentuknya wilayah pertumbuhan baru sebagai hasil perkembangan desa telah memicu pertumbuhan penduduk yang dapat membawa ekses negatif terhadap lingkungan dan keberlanjutannya. Untuk menciptakan kondisi lingkungan yang berkesinambungan harus menyelaraskan tiga komponen pokok yaitu lingkungan, ekonomi, dan sosial. Peran masyarakat menjadi penting, mengingat melalui perilaku sehari-hari dengan persepsi lingkungan yang dimiliki secara langsung atau tidak langsung dapat membuat lingkungan menjadi lebih baik atau lebih buruk. Tujuan penelitian ini adalah untuk mengetahui pengetahuan konseptual tentang indikator perilaku masyarakat terhadap kesadaran dan keberlanjutan lingkungan. Metode penelitian yang dipakai adalah survey eksplanatori. Pengambilan sampel dengan teknik simple random sampling. Teknik analisis menggunakan statistik deskriptif, dan analisis part least square. Hasil penelitian menunjukkan bahwa faktor yang berpengaruh terhadap persepsi dan perilaku sadar lingkungan adalah pendidikan dan pendapatan. Sedangkan indikator umur dan lama waktu kerja tidak berpengaruh terhadap persepsi dan perilaku sadar lingkungan. Keterbatasan biaya, ketersediaan sarana dan tempat menjadi kendala utama dalam mewujudkan perilaku sadar lingkungan. perilaku sadar lingkungan masyarakat dipengaruhi oleh cara pandangnya terhadap lingkungan, sehingga untuk keberlanjutan lingkungan, masyarakat perlu menerapkan prinsip-prinsip etika lingkungan dalam kehidupan sehari-hari.
Refugees in the news: Comparing Belgian and Swedish newspaper coverage of the European refugee situation during summer 2015
Authors: Cock Rozane De , Mertens Stefan , Sundin Ebba , Lams Lutgard , Mistiaen Valeriane , Joris Willem , d’Haenens Leen
Published: July 2018

This comparative content analysis of Belgian and Swedish newspaper coverage of the ‘refugee situation’ in 2015 (N=898) revolves around responsibility indicators, news actor characteristics, and thematic emphasis. As they are a potential influential factor in the public-opinion formation process, the studying of media portrayals is an essential first step in investigating the dynamic interplay between media discourse and societal reactions. Belgium and Sweden differ with respect to migration policy, integration indicators, and the number of incoming refugees. They also differ in terms of journalistic cultural values. As a result, they make for an excellent case study of intercultural differences and similarities in how refugees are reported on. Our analysis made clear that Belgian news coverage shows regional diversity, with Francophone Belgian journalists showing more tolerance towards migrants and thus tending to be more in line with their Swedish counterparts. Still, refugees are seldom allowed to speak for themselves. This warrants attention and action by news professionals.
The Syrian refugee crisis in Scandinavian newspapers
Authors: Hovden Jan Fredrik , Mjelde Hilmar , Gripsrud Jostein
Published: July 2018

This article maps and analyzes quantitatively how the Scandinavian news press covered the 2015 Syrian refugee crisis. Our analysis shows that in the coverage of the migration events, Denmark and Sweden occupy polar positions in terms of their newspapers’ emphasis, with the former appearing more negative towards the refugees, and the latter more positive. The Norwegian case is found in between these. Danish print media more often mention the negative economic consequences of the arrivals, and Swedish the positive moral ones, while Norway appears to occupy a middle ground in the Scandinavian discourse. We also find that the Scandinavian press writes less often about the negative consequences of refugees coming than the European press in general. However, the humanitarian aspects of the crisis became less prominent in the Scandinavian press over time, as in the rest of Europe.
Welfare restrictions and ‘benefit tourists’: Representations and evaluations of EU migrants in the UK
Authors: Demetriou Deanna
Published: July 2018

This article investigates online representations and evaluations of EU migrants, focusing on the notion of ‘benefit tourism’ and discursive strategies used in the (de)legitimization of new welfare restrictions in the UK. Through the examination of online newspapers and corresponding public comment threads, this article adopts theoretical and methodological premises from Critical Discourse Studies (CDS), drawing upon the Discourse-Historical Approach (DHA) to provide both a politically motivated as well as reflexive account. Although new participatory structures allow for resistance to emerge, the openness, scalability and anonymity of the internet also allows for the spread of discrimination through the construction of EU migrants (in particular Bulgarians and Romanians) as the ‘Other’.
A Rare Case of Primary Histiocytic Sarcoma of the Stomach
Authors: Petkova Nina Y. , Hristoskova Radka G. , Guenova Margarita L. , Raynov Julian I.
Published: July 2018

Histiocytic sarcoma is a rare lymphohematopoietic malignancy with aggressive clinical course and poor therapy response. The diagnosis relies on the confirmation of its histiocytic lineage and exclusion of other poorly differentiated tumors. Most of the cases present in extranodal sites, but primary gastric involvement is exceptional. We report a case of a 69-year-old woman with epigastric pain and systemic symptoms. Gastroscopy findings and biopsy report suggested a malignant neoplasm. The patient underwent distal subtotal gastrectomy with a 6-cm tumor in the body and antrum of the stomach and ten associated enlarged perigastric lymph nodes. Microscopically they were infiltrated with atypical tumor cells and immunohistochemical staining was positive for CD68, lysozyme, CD45, and CD4; 45% of the cells stained for Ki-67. The pathologic diagnosis was histiocytic sarcoma. CT body scans showed only enlarged retroperitoneal and abdominal lymph nodes. The patient received six cycles of CHOEP chemotherapy with complete therapeutic response, but three months later she experienced an aggressive systemic sarcoma recurrence and although salvage chemotherapy was initiated she died of progressive disease. The presented case widens the differential diagnosis of gastric malignancies, and emphasizes the significance of immunohistochemical examination for histiocytic sarcoma diagnosis. The collection and evaluation of cases of gastric histiocytic sarcoma are important to obtain further progress in prognosis and treatment.
Treatment of Childhood Acute Myeloid Leukemia in Bulgaria
Authors: Burnusuzov Hasan A. , Yordanova Maya N. , Avramova Boryana E. , Yurukova Nadezhda N. , Bachvarov Konstantin N. , Muchinova Albena B. , Vlahova Irena H. , Stoyanova Angelina A. , Mumdzhiev Ivan N. , Ivanova Liliya R. , Spasov Neofit Y. , Peteva Elina Ts. , Belcheva Milena I. , Hristozova Hristina , Spasova Mariya I. , Kaleva Valeriya I. , Bobev Dragan , Konstantinov Dobrin N.
Published: July 2018

Background: During the last four decades the prognosis of childhood acute myeloid leukemia (AML) has been substantially improved due to an increase in complete remission (CR) rates, event-free survival (EFS) and reduced early mortality. The relapsed AML still remains a therapeutic challenge.

Aim: To report the AML treatment results of the Bulgarian pediatric oncohematological centers.

Materials and methods: Retrospective analysis of the treatment results of children and adolescents (age from 0 to 20 years) with primary AML. Unified AML BFM- backbone type treatment protocol is used.

Results: This study included 97 newly diagnosed patients (44 girls and 53 boys) with AML in Bulgaria between 2003 and 2016. The median age at diagnosis was 10.2 years. The most frequent FAB-morphologic subtype was M2 followed by M4. First complete remission (CR1) was achieved in 83 patients (85.6%). The 13-year EFS was 49%, while the overall survival (OS) was 54.6%. Twenty seven (27.8%) patients relapsed, with only 5 of them being still alive towards the end of the study period.

Conclusion: The EFS and OS for the children with AML in Bulgaria are comparable with those reported by other European groups. The prognosis of relapsed AML remains still unfavorable for the past 13 years.
Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes
Authors: Boyanov Krasimir O. , Maneva Ana I.
Published: July 2018

Background: Cyclic AMP is a powerful inhibitor of platelet aggregation. In the present study we examined the effect of platelet aggregation modulators on cyclic AMP content in human thrombocytes. Of the agents we tested, lactoferrin, wortmannin, quercetin and amiloride are platelet aggregation inhibitors, whereas ouabain is a platelet activator.

Aim: To investigate the effect of lactoferrin, wortmannin, quercetin, ouabain and amiloride applied alone and in combination with lactoferrin on cyclic AMP production in human platelets.

Materials and methods: ‘Direct cAMP ELISA kit’ was used for cyclic AMP determination.

Results: The studied modulators, individually or in combination, stimulate cyclic AMP production in platelets.

Conclusions: Wortmannin, quercetin, ouabain and amiloride increase cyclic AMP level in human platelets. Lactoferrin also increases cyclic AMP level, but the effect is statistically insignificant, which shows that lactoferrin does not participate directly in the cyclic AMP signaling. Lactoferrin additionally augments the stimulating action of wortmannin, quercetin, ouabain and amiloride on the cyclic AMP production. This probably shows a synergetic interference of lactoferrin in signal pathways along with phosphatidylinositol 3-kinase (wortmannin), quercetin (control over protein kinases, the redox state of the cell and ion transport), ouabain and amiloride (mechanisms of ion transport and phosphorylation).
In Vivo Evaluation of Anti-inflammatory Activity of 2-[3-Acetyl- 5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanylbutyric Acid
Authors: Zlatanova Hristina , Vladimirova Stanislava , Kostadinov Ilia , Bijev Atanas T.
Published: July 2018

Background: Persisting inflammatory stimuli cause chronic inflammation recognized as the major factor contributing to the development of a number of diseases. One group of drugs used in the treatment of chronic inflammation is the group of non-steroidal anti-inflammatory drugs and, more specifically, the selective COX-2 inhibitors (coxibs). However, most of the coxibs were withdrawn from the market in view of their safety profile. In the present study, 2-[3-Acetyl-5-(4-chlorophenyl)- 2-methyl-pyrrol-1-yl]-4-methylsulfanyl-butyric acid (compound 3e), an Npyrrolylcarboxylic acid derivative structurally related to celecoxib, is evaluated for anti-inflammatory activity after single and multiple (14 days) administration using an animal inflammation model.

Aim: To evaluate the anti-inflammatory properties of 2-[3-Acetyl-5-(4-chlorophenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanyl-butyric acid (compound 3e) after single and multiple (14 days) administration using an animal inflammation model.

Materials and methods: Forty Wistar rats were allocated into 5 groups (n=8) treated with saline (controls), diclofenac (25 mg/kg b.w.), compound 3e (10, 20 and 40 mg/kg b.w.) intraperitoneally. The volume of the right hind paw of the animals of all groups is measured prior to treatment and two, three and four hours after administration of carrageenan using a plethysmometer (Ugo Basile, Italy). The percentage of paw edema is calculated using the Trinus formula.

Results: In a single administration, compound 3e in doses of 10 and 20 mg/kg b.w. did not inhibit paw edema, while a dose of 40 mg/kg b.w. significantly inhibited carrageenan-induced paw edema at 2 hours in comparison with the control group. After continuous administration, compound 3e in doses of 10, 20 and 40 mg/kg b.w. significantly reduced paw edema at 2, 3, and 4 hours compared to animals treated with saline.

Conclusions: Compound 3e shows anti-inflammatory properties similar to those of diclofenac after continuous administration.
A New Class of Robust Two-Sample Wald-Type Tests
Authors: Ghosh Abhik , Martin Nirian , Basu Ayanendranath , Pardo Leandro
Published: July 2018

Parametric hypothesis testing associated with two independent samples arises frequently in several applications in biology, medical sciences, epidemiology, reliability and many more. In this paper, we propose robust Wald-type tests for testing such two sample problems using the minimum density power divergence estimators of the underlying parameters. In particular, we consider the simple two-sample hypothesis concerning the full parametric homogeneity as well as the general two-sample (composite) hypotheses involving some nuisance parameters. The asymptotic and theoretical robustness properties of the proposed Wald-type tests have been developed for both the simple and general composite hypotheses. Some particular cases of testing against one-sided alternatives are discussed with specific attention to testing the effectiveness of a treatment in clinical trials. Performances of the proposed tests have also been illustrated numerically through appropriate real data examples.
Association between a guided meditation practice, sleep and psychological well-being in type 2 diabetes mellitus patients
Authors: Varghese Mathew P , Balakrishnan Ragavendrasamy , Pailoor Subramanya
Published: July 2018

Background

Type 2 diabetes mellitus [T2DM] is one of the leading causes for mortality. This study examined the role of an self-awareness based guided meditation practice, Cyclic Meditation [CM] on perceived stress, anxiety, depression, sleep and quality of life in T2DM patients.

Design

A single arm pre-post design was used for the study.

Setting

The study was conducted in an auditorium for general public diagnosed with T2DM in Ernakulam, Kerala, India.

Subjects

Subjects were 30 T2DM patients, both male and female of age 50.12 ± 11.15 years and BMI 25.14 ± 4.37 Kg/m2 and not having a history of hospitalisation were randomly recruited for the study following advertisements in national dailies.

Intervention

Participants completed a supervised CM programs in the evenings, 5 days a week for 4 weeks, in addition to their regular medication.

Measures

Perceived stress, anxiety and depression were assessed with Perceived Stress Scale, State Anxiety Inventory and Beck’s depression inventory, respectively. Sleep and quality of life were assessed with Pittsburgh Sleep Quality Index and WHO-Quality of Life – BREF respectively.

Analysis

Changes in the outcome measures from baseline to 4 weeks were compared using paired “t” test.

Results

After 4 weeks, the quality of life and sleep scores increased 7.1% [p = 0.001] and 32.7% [p = 0.001], respectively. The perceived stress, anxiety and depression reduced 26.1% [p = 0.001], 16.01% [p = 0.003] and 37.63% [p = 0.006] as compared to their baseline reports. The CM practice also reduced daytime dysfunction.

Conclusions

A guided self-awareness based meditation program was safe and effective in improving depression, anxiety, perceived stress and enhance sleep and quality of life in T2DM patients, which could be helpful in reducing the future complications of T2DM. Mind management is essential along with medical management to achieve better clinical results.
Statilius Taurus, the Minotaur, and the Conspiracy of Catiline
Authors: Larsen Mik
Published: July 2018

This paper investigates the ties of the Statilius family to the Caesarian party and to Roman politics more generally during the last decades of the Roman Republic. After establishing thegens Statilia's origin and potential political position in Lucania, it contests earlier suppositions about what started the family's prominence in Rome proper. The paper argues that, instead of the Statilii catapulting into prominence at Rome during the time of the Augustannovus homoTitus Statilius Taurus (cos. 36, 27 BCE), their involvement began earlier, as part of the equestrian branch of the conspiratorial followers of Catiline, a datum which might provide enlightenment about the „missing clients“ of Julius Caesar's early career.
Nanotechnology for the oil and gas industry – an overview of recent progress
Authors: Zhe Zhang , Yuxiu An
Published: July 2018

Nanotechnology has brought about revolutionary innovations in many aspects of the oil and gas industry. Nanotechnology generates nanomaterials, which are natural or synthetic materials with at least one dimension at the nanoscale (1–100 nm). Among them, nanoparticles (NPs), in particular, have large surface areas and high volume concentrations. Given these dimensional effects, nanomaterials acquire unique mechanical, chemical, thermal, and magnetic properties and, therefore, have a superior performance than conventional micro and macro materials in a range of oil and gas field applications. Nanomaterials can also be custom functionalized by chemical modifications to meet specific technical requirements. In this review, the developments in the recent years concerning the research on nanotechnology in drilling, completion, reservoir protection, enhance-oil-recovery (EOR), sensing and imaging techniques, stimulation techniques in oil and gas migration and accumulation have been summarized. The aim of this paper was to provide a comprehensive overview of the scientific progress of nanotechnology in the oil and gas research areas, identifying the existing barriers and challenges, and evaluating the technical and economic prospects in this field.
The Verisimilitudinarian approach to ‘the Truth’
Authors: Roselli Andrea
Published: July 2018

The Verisimilitudinarian approach to scientific progress (VS, for short) is traditionally considered a realist-correspondist model to explain the proximity of our best scientific theories to the way things really are in the world out there (ʻthe Truthʻ, with the capital ʻtʻ). However, VS is based on notions, such as ʻestimated verisimilitudeʻ or ʻapproximate truthʻ, that dilute the model in a functionalist-like theory. My thesis, then, is that VS tries to incorporate notions, such as ʻprogressʻ, in a pre-constituted metaphysical conception of the world, but fails in providing a fitting framework. The main argument that I will develop to support this claim is that the notions that they use to explain scientific progress (ʻestimated verisimilitudeʻ or ʻapproximate truthʻ) have nothing to do with ʻthe Truthʻ. After presenting Cevolani and Tamboloʻs answer (2013) to Birdʻs arguments (2007), I will claim that VS sacrifices the realist-correspondist truth in favor of an epistemic notion of truth, which can obviously be compatible with certain kinds of realism but not with the one the authors have in mind (the correspondence between our theories and the way things really are).