bluuebunny/crossref_metadata_2025 huggingface dataset:
How can digital building information modelling (BIM) facilitate climate transition in cities?
Authors: Andersson Réka , Eidenskog Maria
Published: December 2020

Digitalization of the construction industry is considered important in combating climate change through more efficient use of resources and better control of energy calculations. Digital modelling of buildings is argued to make building’s energy use more efficient through better energy management. However, research regarding the use of the promising digital tool Building Information Modelling (BIM) has shown that BIM creates unclear roles, division of responsibilities and that cultural barriers between professional groups can be a problem. This paper focuses on how the work with BIM is organized and what conditions are needed to create effective workflows with BIM. The methodology consists of a literature study of digitalization processes in the construction industry and workshops with different professionals. Workshops as a research method provides an exploratory way to understand complex issues, as well as knowledge processes, in relation to digital tools. The co-productive format of the workshops facilitates conversations where different professional groups meet and share experiences of working with BIM. The study shows that several requirements needs to be met to fully make use of the BIM potential. Communication between different professions, knowledge transfer over project boarders, different standards and competence, both within and in relation to the clients, are important components when working with BIM. There is a need for interdisciplinary work practices which are complicated by the project organizational form most used in construction industry. For BIM to be utilized as a tool to combat climate change in cities through effective resource planning, the organizational settings and workflows needs to be interdisciplinary and communication between departments, clients and professions must be standardized while still flexible.
Multi-user network paves the way towards a quantum internet
Authors: Wogan Tim
Published: December 2020

Researchers in the UK and Austria have demonstrated secure information exchange between multiple users spaced around a city.
CERN’s emissions equal to a large cruise liner, says report
Authors: Ravilious Kate
Published: December 2020

Greenhouse-gas emissions emitted by the CERN particle-physics lab near Geneva in 2018 were 223,800 tonnes of carbon-dioxide equivalent – similar to the emissions from a large cruise liner.
Cash boost for Giant Magellan Telescope
Authors: Kruesi Liz
Published: December 2020

Construction of the Giant Magellan Telescope (GMT) is to speed up after the National Science Foundation (NSF) awarded the GMTO Corporation – the organization overseeing construction and management of the 25 m-wide telescope – a grant of $17.5m over the next three years.
Monumental mistake
Authors: P Crease Robert
Published: December 2020

Robert P Crease laments the disappearance of a landmark in US science history
Intrepid interstellar adventurers
Authors: Randall Ian
Published: December 2020

Science journalist Christopher Wanjek’s enchanting new book, Spacefarers: How Humans Will Settle the Moon, Mars, and Beyond explores the challenges and motivations of recreating the Earth-like conditions necessary for our survival, out in space and on neighbouring worlds.
Investigating the Efficacy of Genetic, Environmental, and Multifactorial Risk Information When Communicating Obesity Risk to Parents of Young Children
Authors: Persky Susan , Yaremych Haley E , Goldring Megan R , Ferrer Rebecca A , Rose Margaret K , Hollister Brittany M
Published: December 2020

Background

Effectively communicating with parents about children’s obesity risk is of critical importance for preventive medicine and public health.

Purpose

The current study investigates the efficacy of communications focused on two primary causes of obesity: genes and environment.

Methods

We compared parental feeding responses to messages focused on (i) genetics alone, (ii) family environment alone, (iii) genetics–family environment interaction (G × FE), and (iv) no causal message. We also examined whether parental guilt mediates the effect of message type on feeding. Our sample consisted of 190 parents, half mothers and half fathers, of children 3–7 years old. After receiving one of the four types of messages, parents chose foods for their child using the Virtual Reality Buffet measure. Parents responded to questionnaires in the lab and at 1-week follow-up.

Results

In the VR Buffet, parents did not feed their children differently in message provision conditions versus control. There were, however, differences among message provision conditions wherein mothers who received any genetic information chose higher-calorie meals in the VR Buffet. At 1-week follow-up, parents who received information about genetics alone reported feeding their child more junk food and fatty meat on self-report food frequency assessments; there were no such differences for sugary beverages, sugary foods, or fast foods. Parental guilt was typically higher for participants who received family environment information alone but did not mediate the relation between information provision and feeding outcomes.

Conclusions

While none of the messages improved feeding above the control condition, GxFE messages were associated with a better overall profile of outcomes. As such, it may be beneficial for messaging for parents about children’s obesity risk to include content that reflects the complexity of genetic and environmental contributions to obesity risk.
Targeting the Opioid Receptors: A Promising Therapeutic Avenue for Treatment in “Heavy Drinking Smokers”
Authors: Domi Ana , Barbier Estelle , Adermark Louise , Domi Esi
Published: December 2020

Aims

Despite a general decline in tobacco use in the last decades, the prevalence of tobacco smoking in individuals with alcohol use disorder (AUD) remains substantial (45–50%). Importantly, the co-use of both substances potentiates the adverse effects, making it a significant public health problem. Substantial evidence suggests that AUD and Tobacco use disorder (TUD) may share common mechanisms. Targeting these mechanisms may therefore provide more effective therapy. Numerous studies describe a potential role of the endogenous opioid system in both AUD and TUD. Reviewing this literature, we aim to evaluate the efficacy of molecules that target the opioid system as promising therapeutic interventions for treating alcohol and tobacco co-use disorders.

Methods

We provide a synthesis of the current epidemiological knowledge of alcohol and tobacco co-use disorders. We evaluate clinical and preclinical research that focuses on the regulation of the endogenous opioid system in alcohol, nicotine, and their interactions.

Results

The epidemiological data confirm that smoking stimulates heavy drinking and facilitates alcohol craving. Pharmacological findings suggest that treatments that are efficacious in the dual addiction provide a beneficial treatment outcome in comorbid AUD and TUD. In this regard, MOP, DOP and NOP-receptor antagonists show promising results, while the findings prompt caution when considering KOP-receptor antagonists as a treatment option in alcohol and tobacco co-use disorders.

Conclusions

Existing literature suggests a role of the opioid system in sustaining the high comorbidity rates of AUD and TUD. Molecules targeting opioid receptors may therefore represent promising therapeutic interventions in ‘heavy drinking smokers.’
Integration of gene interaction information into a reweighted Lasso-Cox model for accurate survival prediction
Authors: Wang Wei , Liu Wei
Published: December 2020

Motivation

Accurately predicting the risk of cancer patients is a central challenge for clinical cancer research. For high-dimensional gene expression data, Cox proportional hazard model with the least absolute shrinkage and selection operator for variable selection (Lasso-Cox) is one of the most popular feature selection and risk prediction algorithms. However, the Lasso-Cox model treats all genes equally, ignoring the biological characteristics of the genes themselves. This often encounters the problem of poor prognostic performance on independent datasets.

Results

Here, we propose a Reweighted Lasso-Cox (RLasso-Cox) model to ameliorate this problem by integrating gene interaction information. It is based on the hypothesis that topologically important genes in the gene interaction network tend to have stable expression changes. We used random walk to evaluate the topological weight of genes, and then highlighted topologically important genes to improve the generalization ability of the RLasso-Cox model. Experiments on datasets of three cancer types showed that the RLasso-Cox model improves the prognostic accuracy and robustness compared with the Lasso-Cox model and several existing network-based methods. More importantly, the RLasso-Cox model has the advantage of identifying small gene sets with high prognostic performance on independent datasets, which may play an important role in identifying robust survival biomarkers for various cancer types.

Availability and implementation

http://bioconductor.org/packages/devel/bioc/html/RLassoCox.html

Supplementary information

Supplementary data are available at Bioinformatics online.
From matte banded to glossy black: structures underlying colour change in the caudal lures of southern death adders (Acanthophis antarcticus,Reptilia: Elapidae)
Authors: Crowe-Riddell Jenna M , Dix Stacey , Pieterman Ludo , Nankivell James H , Ford Matthew , Ludington Alastair J , Simões Bruno F , Dunstan Nathan , Partridge Julian C , Sanders Kate L , Allen Luke
Published: December 2020

Many ambush-foraging snakes move their tails to entice prey within striking range (‘caudal luring’). During ontogeny, the conspicuous hues of caudal lures change to match the cryptic patterning of the body/head. This coincides with decreased luring behaviour and reflects the trade-off between prey acquisition and camouflage as the snake grows. Australo-Papuan death adders (Acanthophis, Elapidae) are unique in that both juveniles and adults use caudal luring, but ontogenetic colour change has not been investigated. We examined the spectral reflectance, microstructure and pigmentation of caudal skin in wild-sourced and captive bred Acanthophis antarcticus ranging in body size (snout-vent length 116–674 mm; mass 3–832 g; N = 33) to test whether colour properties change as snakes grow. We found that lure colour is distinct from the cryptic body skin across the life history, and changes from a matte banding pattern (grey/black) in neonates/juveniles, to uniform and glossy black with a yellow ventral stripe in larger snakes. These colour changes are caused by increases in dermal pigmentation and a transition to a smooth, interlocking epidermal microstructure. To understand the selection pressures that might be driving ontogenetic colour change in this species, further studies should test how different prey types respond to distinct lure morphologies.
Impact of COVID-19 outbreak on esophageal cancer surgery in Northern Italy: lessons learned from a multicentric snapshot
Authors: Rebecchi Fabrizio , Arolfo Simone , Ugliono Elettra , Morino Mario , Asti Emanuele , Bonavina Luigi , Borghi Felice , Coratti Andrea , Cossu Andrea , De Manzoni Giovanni , De Pascale Stefano , Ferrari Giovanni Carlo , Fumagalli Romario Uberto , Giacopuzzi Simone , Gualtierotti Monica , Guglielmetti Massimo , Merigliano Stefano , Pallabazzer Giovanni , Parise Paolo , Peri Andrea , Pietrabissa Andrea , Rosati Riccardo , Santi Stefano , Tribuzi Angela , Valmasoni Michele , Viganò Jacopo , Weindelmayer Jacopo
Published: December 2020

Coronavirus Disease-19 (COVID-19) outbreak has significantly burdened healthcare systems worldwide, leading to reorganization of healthcare services and reallocation of resources. The Italian Society for Study of Esophageal Diseases (SISME) conducted a national survey to evaluate changes in esophageal cancer management in a region severely struck by COVID-19 pandemic. A web-based questionnaire (26 items) was sent to 12 SISME units. Short-term outcomes of esophageal resections performed during the lockdown were compared with those achieved in the same period of 2019. Six (50%) centers had significant restrictions in their activity. However, overall number of resections did not decrease compared to 2019, while a higher rate of open esophageal resections was observed (40 vs. 21.7%; P = 0.034). Surgery was delayed in 24 (36.9%) patients in 6 (50%) centers, mostly due to shortage of anesthesiologists, and occupation of intensive care unit beds from intubated COVID-19 patients. Indications for neoadjuvant chemo (radio) therapy were extended in 14% of patients. Separate COVID-19 hospital pathways were active in 11 (91.7%) units. COVID-19 screening protocols included nasopharyngeal swab in 91.7%, chest computed tomography scan in 8.3% and selective use of lung ultrasound in 75% of units. Postoperative interstitial pneumonia occurred in 1 (1.5%) patient. Recovery from COVID-19 pandemic was characterized by screening of patients in all units, and follow-up outpatient visits in only 33% of units. This survey shows that clinical strategies differed considerably among the 12 SISME centers. Evidence-based guidelines are needed to support the surgical esophageal community and to standardize clinical practice in case of further pandemics.
Similar outcomes with manual contact force ablation catheters and traditional catheters in the treatment of outflow tract premature ventricular complexes
Authors: Ábrahám Pál , Ambrus Mercédesz , Herczeg Szilvia , Szegedi Nándor , Nagy Klaudia Vivien , Salló Zoltán , Osztheimer István , Széplaki Gábor , Tahin Tamás , Merkely Béla , Gellér László
Published: December 2020

Aims

Unlike in atrial fibrillation ablation, there is a lack of appropriately sized and properly designed studies regarding outflow tract (OT) premature ventricular complex (PVC) ablation outcomes with contact force sensing (CFS) catheters. We aimed to compare the acute success-, complication-, and long-term recurrence rates of manual CFS catheters with traditional irrigated catheters (T) in OT PVC ablation.

Methods and results

Single-centre, propensity-matched data of 75–75 patients ablated for right-sided OT (RVOT) or left-sided OT (LVOT) PVCs in 2015–17 with CFS or T catheters were compared. Acute success rate, peri-procedural complications, post-procedural daily PVC burden, and long-term recurrence rates were compared on intention-to-treat basis. Acute success rate equalled 80% in both groups, with no difference in force values in the CFS group comparing successful or failed cases [12.0 (8.75–17.0) vs. 16.0 (10.25–22.25) g, P = 0.21]. There were three cases of pseudo-aneurysm and one cardiac tamponade. PVC burden fell significantly from baseline 22 (15–30)% to 2 (0–10)% (P < 0.0001), with no difference between catheter types [CFS: 1 (0–7)% vs. T: 4 (1–12) %; P = 0.21]. There was no significant difference in recurrence-free survival of CFS and T catheters (58 vs. 59%, P = 0.29) during 12 months of follow-up, respectively. Recurrence in the CFS group did not differ either by the force exerted below or above the median value of 12 g (P = 0.66).

Conclusion

Both types of catheters can effectively reduce OT PVC burden with minimal serious complication rates. Ablation with CFS or T catheters gives similar acute- and long-term results.
Economic Depreciation of In-Woods Forestry Equipment in the US South
Authors: McConnell T Eric
Published: December 2020

Forestry machines sold at auctions across the southern United States covering the years 2005 to 2019 (n = 640) were compiled into three equipment categories—rubber-tired feller bunchers, grapple skidders, and trailer-mounted loaders—with inflationary effects removed. The data were discounted by a reliability function derived from a two-parameter Weibull distribution, which defined the probability of future operability at machine hours h and a wrecking value based on each machine’s specified worth as scrap. These adjusted salvage values were then transformed using the Box-Cox normal method. Age affected all fellers and certain manufacturers of skidders and loaders. A significant annual use effect was revealed for fellers and skidders. Interactions of age and use with horsepower revealed that machine size influenced buyers’ feller and skidder purchasing decisions. Manufacturer intercept and slope shifters pointed to potential brand recognition by buyers. Perceived quality differences between manufacturers, however, were not revealed. Depreciation occurred at ever-increasing rates over machine lifetime.
The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study
Authors: Jain Purva , Bellettiere John , Glass Nicole , LaMonte Michael J , Di Chongzhi , Wild Robert A , Evenson Kelly R , LaCroix Andrea Z
Published: December 2020

Background

Self-reported time spent standing has been associated with lower risk of mortality. No previous studies have examined this association using device-measured standing.

Method

This was a prospective cohort study of 5878 older (median age = 80 years), racial/ethnically diverse, community-dwelling women in the WHI Objective Physical Activity and Cardiovascular Health Study (OPACH). Women wore accelerometers for 1 week and were followed for mortality. The study applied previously validated machine learning algorithms to ActiGraph GT3X+ accelerometer data to separately measure time spent standing with and without ambulation. Cox proportional hazards models were used to estimate mortality risk adjusting for potential confounders. Effect modification by age, body mass index, moderate-to-vigorous physical activity, sedentary time, physical functioning, and race/ethnicity was evaluated.

Results

There were 691 deaths during 26 649 person-years of follow-up through March 31, 2018 (mean follow-up = 4.8 years). In fully adjusted models, all-cause mortality risk was lower among those with more standing without ambulation (quartile [Q] 4 vs Q1 HR = 0.63; 95% CI = 0.49–0.81, p-trend = .003) and more standing with ambulation (Q4 vs Q1 HR = 0.50; 95% CI = 0.35–0.71, p-trend < .001). Associations of standing with ambulation and mortality were stronger among women with above-median sedentary time (HR = 0.51; 95% CI = 0.38–0.68) compared to women with below-median sedentary time (HR = 0.80; 95% CI = 0.59–1.07; p-interaction = .02).

Conclusions

In this prospective study among older women, higher levels of accelerometer-measured standing were associated with lower risks of all-cause mortality. Standing is an achievable approach to interrupting prolonged sedentary time, and if not contraindicated, is a safe and feasible behavior that appears to benefit health in older ages.
Unifying package managers, workflow engines, and containers: Computational reproducibility with BioNix
Authors: Bedő Justin , Di Stefano Leon , Papenfuss Anthony T
Published: December 2020

Motivation

A challenge for computational biologists is to make our analyses reproducible—i.e. to rerun, combine, and share, with the assurance that equivalent runs will generate identical results. Current best practice aims at this using a combination of package managers, workflow engines, and containers.

Results

We present BioNix, a lightweight library built on the Nix deployment system. BioNix manages software dependencies, computational environments, and workflow stages together using a single abstraction: pure functions. This lets users specify workflows in a clean, uniform way, with strong reproducibility guarantees.

Availability and Implementation

BioNix is implemented in the Nix expression language and is released on GitHub under the 3-clause BSD license: https://github.com/PapenfussLab/bionix (biotools:BioNix) (BioNix, RRID:SCR_017662).
The Patterns of Use of Medications for Inflammatory Bowel Disease During Pregnancy in the US and Sweden Are Changing
Authors: Bröms Gabriella , Friedman Sonia , Kim Seoyoung C , Wood Mollie E , Hernandez-Diaz Sonia , Brill Gregory , Bateman Brian T , Huybrechts Krista F , Desai Rishi J
Published: December 2020

Background

Population-level data spanning different countries describing oral and parenteral treatment in pregnant women with inflammatory bowel disease (IBD) are scarce. We studied treatment with sulfasalazine/5-aminosalicylates, corticosteroids, thiopurines/immunomodulators, and tumor necrosis factor (TNF)-inhibitors in the United States (Optum Clinformatics Data Mart and the Medicaid Analytics Extract [MAX]) and in the Swedish national health registers.

Methods

We identified 2975 pregnant women in Optum (2004–2013), 3219 women in MAX (2001–2013), and 1713 women in Sweden (2006–2015) with a recorded diagnosis of IBD. We assessed patterns of use for each drug class according to filled prescriptions, assessing frequency of treatment continuation in those that were treated in the prepregnancy period.

Results

The proportion of women with Crohn’s disease and ulcerative colitis on any treatment during pregnancy was 56.1% and 56.3% in Optum, 47.5% and 49.3% in MAX, and 61.3% and 64.7% in Sweden, respectively, and remained stable over time. Sulfasalazine/5-aminosalicylates was the most commonly used treatment in Crohn’s disease, ranging from 25.1% in MAX to 31.8% in Optum, and in ulcerative colitis, ranging from 34.9% in MAX to 53.6% in Sweden. From 2006 to 2012, the TNF-inhibitor use increased from 5.0% to 15.5% in Optum, from 3.6% to 8.5% in MAX, and from 0.7% to 8.3% in Sweden. Continuing TNF-inhibitor treatment throughout pregnancy was more common in Optum (55.8%) and in MAX (43.0%) than in Sweden (11.8%).

Conclusions

In this population-based study from 2 countries, the proportion of women with IBD treatment in pregnancy remained relatively constant. TNF-inhibitor use increased substantially in both countries.
Early Changes in Serum Albumin Predict Clinical and Endoscopic Outcomes in Patients With Ulcerative Colitis Starting Anti-TNF Treatment
Authors: Lee Sun-Ho , Walshe Margaret , Oh Eun Hye , Hwang Sung Wook , Park Sang Hyoung , Yang Dong-Hoon , Byeon Jeong-Sik , Myung Seung-Jae , Yang Suk-Kyun , Greener Tomer , Weizman Adam V , Silverberg Mark S , Ye Byong Duk
Published: December 2020

Background

Up to 60% of patients with ulcerative colitis (UC) ultimately fail anti-tumor necrosis factor (TNF) treatment. We aimed to investigate early predictive markers of clinical and endoscopic outcomes in patients with UC who were anti-TNF-naïve commencing anti-TNF treatment, with particular focus on changes in albumin and C-reactive protein levels in the first 2 weeks of treatment.

Methods

We retrospectively investigated 210 patients with UC who started infliximab or adalimumab between 2009 and 2016 (male, 62.4%; median age at diagnosis, 37.9 years [interquartile range, 25.5–48.9 years]; median follow-up duration, 3.3 years [1.9–5.0 years]). Logistic and Cox proportional-hazards regressions were performed to identify variables associated with primary nonresponse (PNR), endoscopic outcomes, time-to-colectomy, and anti-TNF failure.

Results

Forty-one patients (19.5%) experienced PNR; week 0/week 2 ratio serum albumin was associated with PNR (adjusted odds ratio [aOR], 1.8; 95% confidence interval [CI], 1.1–2.9, per interquartile range increase). Week 0/week 2 ratio albumin was also associated with endoscopic response (aOR, 0.28; 95% CI, 0.31–0.82) and endoscopic remission (aOR, 0.61; 95% CI, 0.39–0.96) at weeks 8 to 14, time-to-colectomy (adjusted hazard ratio, 2.12; 95% CI, 1.29–3.49) and time-to-anti-TNF failure (adjusted hazard ratio, 1.54; 95% CI, 1.22–1.96), regardless of age, disease severity, or in-patient status. Association with time-to-colectomy and anti-TNF failure was externally validated in an independent cohort of inpatients with UC starting infliximab.

Conclusions

Change in serum albumin within the first 2 weeks of anti-TNF treatment is predictive of PNR, endoscopic outcomes, time-to-colectomy, and anti-TNF failure in patients with UC. Timely access to this biomarker enables early identification of patients with UC at risk of anti-TNF failure and may guide early optimization of anti-TNF treatment to improve disease outcomes.
Immunogenicity of Tumor Necrosis Factor Antagonists and Effect of Dose Escalation on Anti-Drug Antibodies and Serum Drug Concentrations in Inflammatory Bowel Disease
Authors: Battat Robert , Lukin Dana , Scherl Ellen J , Pola Suresh , Kumar Anand , Okada Lauren , Yang Lei , Jain Anjali , Siegel Corey A
Published: December 2020

Background

Infliximab and adalimumab concentrations are associated with important outcomes in inflammatory bowel disease (IBD). Antibodies to infliximab (ATI) and adalimumab (ATA) are associated with reduced drug concentrations and worse outcomes. Because the efficacy of dose escalation to overcome antibodies is unclear, we assessed the impact of this strategy to overcome immunogenicity in IBD.

Methods

Infliximab and adalimumab dosing, drug, and antibody concentrations were extracted from a database of patients with IBD having specimens collected for therapeutic drug monitoring. The primary outcome compared proportions with either infliximab ≥5 μg/mL or adalimumab ≥7.5 μg/mL and undetectable antibodies between dose-escalated and non-escalated patients. Area under the receiver operating characteristic curve analyses determined antibody concentrations below which dose escalation was associated with the primary outcome.

Results

The study included 63,176 patients treated with infliximab and 46,429 patients treated with adalimumab. We detected ATI and ATA in 23.6% (n = 14,900) of patients treated with infliximab and 19.6% (n = 9101) of patients treated with adalimumab. In patients with ATI, infliximab dose escalation (n = 453) yielded higher proportions achieving the primary outcome (47.5% vs 30.9%; P < 0.001), greater drug concentration increases (5.9 μg/mL vs 0.2 μg/mL; P < 0.001), and ATI reductions (4.3 U/mL vs 1.9 U/mL; P = 0.002) compared to no escalation (n = 204). An ATI threshold of 8.55 U/mL was associated with achieving the primary outcome with dose escalation (area under the curve = 0.66). For patients with ATI ≤8.55 U/mL (n = 274), higher proportions (59.1% vs 29.6%; P < 0.001) achieved the primary outcome compared with those with ATI >8.55 U/mL (n = 179). No patients treated with adalimumab achieved the primary outcome (0/390), regardless of dose escalation (n = 87).

Conclusion

Dose escalation increased drug concentrations and eliminated antibodies with infliximab but not adalimumab. Initial ATI ≤8.55 U/mL was associated with increased efficacy of dose escalation using this assay.
The information complexity of learning tasks, their structure and their distance
Authors: Achille Alessandro , Paolini Giovanni , Mbeng Glen , Soatto Stefano
Published: December 2020

We introduce an asymmetric distance in the space of learning tasks and a framework to compute their complexity. These concepts are foundational for the practice of transfer learning, whereby a parametric model is pre-trained for a task, and then fine tuned for another. The framework we develop is non-asymptotic, captures the finite nature of the training dataset and allows distinguishing learning from memorization. It encompasses, as special cases, classical notions from Kolmogorov complexity and Shannon and Fisher information. However, unlike some of those frameworks, it can be applied to large-scale models and real-world datasets. Our framework is the first to measure complexity in a way that accounts for the effect of the optimization scheme, which is critical in deep learning.
The generalized orthogonal Procrustes problem in the high noise regime
Authors: Pumir Thomas , Singer Amit , Boumal Nicolas
Published: December 2020

We consider the problem of estimating a cloud of points from numerous noisy observations of that cloud after unknown rotations and possibly reflections. This is an instance of the general problem of estimation under group action, originally inspired by applications in three-dimensional imaging and computer vision. We focus on a regime where the noise level is larger than the magnitude of the signal, so much so that the rotations cannot be estimated reliably. We propose a simple and efficient procedure based on invariant polynomials (effectively: the Gram matrices) to recover the signal, and we assess it against fundamental limits of the problem that we derive. We show our approach adapts to the noise level and is statistically optimal (up to constants) for both the low and high noise regimes. In studying the variance of our estimator, we encounter the question of the sensivity of a type of thin Cholesky factorization, for which we provide an improved bound which may be of independent interest.
Making Geoeconomics an IR Research Program
Authors: Kim Dong Jung
Published: December 2020

In contrast to growing public attention to geoeconomics as the new mode of conducting great power competition, the IR discipline has not actively engaged in conceptual and theoretical analysis from the geoeconomic viewpoint. This article examines issues that geoeconomics needs to solve to become a new theoretical framework in the positivist “American” IR scholarship that dominates research on great power competition. On the one hand, the concept of geoeconomics needs to be redefined and account for a phenomenon that is not already covered in extant IR scholarship. Thus, geoeconomics should be considered as a form of grand strategy and defined as the use of economic instruments to advance mid- to long-term strategic interests in a geographical region of the world. On the other hand, geoeconomics in positivist IR should take into account international economic structure and domestic politics in developing a parsimonious explanation for the conditions to employ geoeconomic grand strategy. In this process, the theorist needs to make an analytical choice to concentrate on certain factors and mechanisms to assure theoretical parsimony. This article concludes that addressing the issues of conceptual clarity and parsimonious theorization would potentially allow geoeconomics to become a new research program in positivist IR.
The Financial Consequences of Rating International Institutions: Competition, Collaboration, and the Politics of Assessment
Authors: Lall Ranjit
Published: December 2020

The past 15 years have witnessed a striking trend in global governance: the creation of comparative indicators of the performance of international institutions by donor states seeking to allocate their resources more efficiently. Interestingly, however, not all highly rated institutions have been “rewarded” with increased contributions, while not all poorly rated institutions have been “punished” with funding cuts or freezes. I argue that the financial impact of performance indicators is contingent upon the relationship between institutions and other actors within their environment, with stronger effects occurring when institutions (1) are subject to a higher degree of resource competition and (2) possess deeper and more extensive operational alliances with actors above and below the state. I test the argument using a mixed-methods strategy that draws on a variety of original sources, including key informant interviews and a new dataset covering fifty-three institutions over the period 2000–2016. The findings enhance our understanding of when and why comparative performance indicators influence resource flows to assessed entities.
Rethinking Authoritarian Power: The Logistics Space and Authoritarian Practices in and between Secondary Port Cities of the Global South
Authors: Jenss Alke , Schuetze Benjamin
Published: December 2020

How to rethink authoritarian power in ways that better account for authoritarian connections beyond nation-state boundaries? By reconceptualizing the context in which to analyze authoritarian power, we bring to light transregional authoritarian connections between the secondary port cities Aqaba/Jordan and Buenaventura/Colombia. We demonstrate that processes of privatization and a continuum of pre-emptive, technocratizing, and repressive authoritarian practices with the overall purpose of enabling capital accumulation occur in a remarkably entangled manner in both locales, even if located at seemingly unconnected geographical sites. By thinking of Aqaba and Buenaventura as occupying the same “transregional authoritarian logistics space” (TALS), we understand Buenaventura through Aqaba, and vice versa. This crisscrossing of established notions of context has important implications for our understanding of authoritarianism and future transregional research designs. As a unit of analysis, the TALS allows us to highlight the role of global logistics players and “developmental aid” agencies—actors rarely discussed in literature on authoritarianism—in rearticulating boundaries within and beyond the nation-state based on class and race. Our contribution calls for an understanding of authoritarian power as transregionally entangled, rather than separate and limited to the nation-state and builds on literatures on authoritarian practices, authoritarian neoliberalism, critical logistics, and transregional connections.
Engaging the “Animal Question” in International Relations
Authors: Fougner Tore
Published: December 2020

By raising the “animal question” in International Relations (IR), this essay seeks to contribute not only to put animals and human–animal relations on the IR agenda, but also to move the field in a less anthropocentric and non-speciesist direction. More specifically, the essay does three things: First, it makes animals visible within some of the main empirical realms conventionally treated as the subject matter of IR. Second, it reflects on IR's neglect of animals and human–animal relations in relation to both how IR has been constituted as a field and the broader socio-cultural context in which it is embedded. Third, it explores various ways in which IR scholars can start incorporating and take animals and human–animal relations seriously in studies on international relations.
Higher West Nile Virus Infection in Aedes albopictus (Diptera: Culicidae) and Culex (Diptera: Culicidae) Mosquitoes From Lower Income Neighborhoods in Urban Baltimore, MD
Authors: Rothman Sarah E , Jones Jennifer A , LaDeau Shannon L , Leisnham Paul T
Published: December 2020

The temperate United States has experienced increasing incidence of mosquito-borne diseases. Recent studies conducted in Baltimore, MD have demonstrated a negative relationship between abundances of Aedes albopictus (Skuse) and Culex mosquitoes and mean neighborhood income level, but have not looked at the presence of pathogens. Mosquitoes collected from five socioeconomically variable neighborhoods were tested for infection by West Nile, chikungunya, and Zika viruses in 2015 and 2016, and again from four of the neighborhoods in 2017. Minimum infection rates of pooled samples were compared among neighborhoods for each year, as well as among individual blocks in 2017. West Nile virus was detected in both Ae. albopictus and Culex pools from all neighborhoods sampled in 2015 and 2017. No infected pools were detected in any year for chikungunya or Zika viruses, and none of the target viruses were detected in 2016. Infection rates were consistently higher for Culex than for Ae. albopictus. Minimum infection rate was negatively associated with mean neighborhood income for both species in 2015. Although earlier work has shown a positive association between block-level abandonment and mosquito abundance, no association was detected in this study. Still, we demonstrate that viral infection in mosquito pools can differ substantially across adjacent urban neighborhoods that vary by income. Though trap security and accessibility often inform city sampling locations, detecting and managing arboviral risk requires surveillance across neighborhoods that vary in socioeconomics, including lower income areas that may be less accessible and secure but have higher infection rates.
Social Skills Instruments for Children with Autism Spectrum Disorder: A Critical Interpretive Synthesis
Authors: West Rebecca , Silverman Michael J
Published: December 2020

Identifying and critically analyzing the most frequently used social skills psychometric instruments (SSPI) for children with autism spectrum disorder (ASD) can inform future music therapy research and clinical practice. Therefore, the initial purpose of this critical interpretive synthesis was to identify the SSPI most frequently used as dependent measures in the Journal of Autism and Developmental Disorders (JADD) for children with ASD from 2012 to 2018. Results indicated that the Social Responsiveness Scale (n = 35), Autism Diagnostic Observation Schedule (n = 19), and Vineland Adaptive Behavior Scales (n = 15) were the most frequently used instruments. Congruent with critical interpretive synthesis methodology, we then identified the psychometric properties and advantages and disadvantages of the 9 most commonly used instruments. To compare these results with the existing music therapy literature, we also identified nonmusical SSPI used as dependent measures in music therapy research for children with ASD in studies published between 2012 and 2018. In comparing the data sets, music therapy researchers used 5 of the 9 SSPI we identified from our JADD review. Understanding frequently used SSPI has applications for consultation and communication with other professionals as well as how future music therapy research is conducted. Implications for clinical practice, limitations of the study, and suggestions for future research are provided.
Economic Significance of Continued Improvement of Loblolly Pine Genetics and Its Efficient Deployment to Landowners in the Southern United States
Authors: McKeand Steven E , Payn Kitt G , Heine Austin J , Abt Robert C
Published: December 2020

The economic consequence of continuing or increasing the tree improvement efforts for loblolly pine (Pinus taeda L.) in the southern United States is immense. For the more than one million acres planted each year with germplasm from the North Carolina State University Cooperative Tree Improvement Program, the present value of continuing current tree breeding efforts and deploying the genetic gains to landowners is estimated to be more than $1.7 billion at current prices. The present value of increasing the rate of genetic gain from 1% per year to 1.1% per year is $211 million. These analyses can be used to justify maintaining and even increasing efforts in tree improvement. With the aggressive fourth-cycle breeding program underway and plans for fifth-cycle breeding and deployment strategies being developed, we have every reason to believe that this trend for at least 1% gain per year will continue for decades, provided the resources to continue tree improvement efforts remain available. Even a modest increase in genetic gain per year would be justification for stakeholders to invest more than $12 million per year to realize this gain.
Spectrum of Cardiovascular Diseases in Children During High Peak Coronavirus Disease 2019 Period Infection in Northern Italy: Is There a Link?
Authors: Fabi Marianna , Filice Emanuele , Andreozzi Laura , Conti Francesca , Gabrielli Liliana , Balducci Anna , Vergine Gianluca , Cicero Cristina , Iughetti Lorenzo , Guerzoni Maria Elena , Corinaldesi Elena , Lazzarotto Tiziana , Pession Andrea , Lanari Marcello
Published: December 2020

Background

Children with coronavirus disease-2019 (COVID-19) have a milder clinical course than adults. We describe the spectrum of cardiovascular manifestations during a COVID-19 outbreak in Emilia-Romagna, Italy.

Methods

A cross-sectional multicenter study was performed, including all patients diagnosed with Kawasaki disease (KD), myocarditis, and multisystem inflammatory syndrome in children (MIS-C) from February to April 2020. KD patients were compared with those diagnosed before the epidemic.

Results

KD: 8 patients (6/8 boys, all negative for severe acute respiratory syndrome coronavirus-2 [SARS-CoV-2]): complete presentation in 5/8, 7/8 immunoglobulin (IVIG) responders, and 3/8 showed transient coronary lesions (CALs). Myocarditis: one 5-year-old girl negative for SARS-CoV-2 and positive for parvovirus B19. She responded to IVIG. MIS-C: 4 SARS-CoV-2-positive boys (3 patients with positive swab and serology and 1 patient with negative swab and positive serology): 3 presented myocardial dysfunction and pericardial effusion, and 1 developed multicoronary aneurysms and hyperinflammation; all responded to treatment. The fourth boy had mitral and aortic regurgitation that rapidly regressed after steroids.

Conclusions

KD, myocarditis, and MIS-C were distinguishable cardiovascular manifestations. KD did not show a more aggressive form compared with previous years: coronary involvement was frequent but always transient. MIS-C and myocarditis rapidly responded to treatment without cardiac sequelae despite high markers of myocardial injury at the onset, suggesting a myocardial depression due to systemic inflammation rather than focal necrosis. Evidence of actual or previous SARS-CoV-2 infection was documented only in patients with MIS-C.
On computable aspects of algebraic and definable closure
Authors: Ackerman Nathanael , Freer Cameron , Patel Rehana
Published: December 2020

We investigate the computability of algebraic closure and definable closure with respect to a collection of formulas. We show that for a computable collection of formulas of quantifier rank at most $n$, in any given computable structure, both algebraic and definable closure with respect to that collection are $\varSigma ^0_{n+2}$ sets. We further show that these bounds are tight.
Analysis of U.S. Pacific Command Area of Operations Military Medical Transportations of Adult Patients, 2008 to 2018
Authors: Pawlukiewicz Alec J , Bridwell Rachel E , Carius Brandon M , Schauer Steven G , Maddry Joseph K , Davis William T
Published: December 2020

Introduction

With more than 370,000 military and civilian personnel stationed across Pacific Command (PACOM), medical evacuation in this largest command presents unique challenges. The authors describe medical evacuations analyzed from the U.S. Air Force Transportation Command Regulating and Command & Control Evacuation System (TRAC2ES) in PACOM.

Materials and Methods

We performed a retrospective review of all TRAC2ES medical records for medical evacuations of adult patients from the PACOM theater of operations conducted between January 1, 2008 and December 31, 2018. We abstracted free text data entry in TRAC2ES to characterize the diagnoses requiring patient movement. Data are presented using descriptive statistics.

Results

During this 11-year period, 3,328 PACOM TRAC2ES encounters met inclusion criteria. Of these evacuations, 65.8% were male and were comprised mostly of active duty military (1,600, 48.1%) and U.S. civilians (1,706, 51.3%). Most transports originated in Japan (1,210 transports, 36.4%) or Guam (924 transports, 27.8%) with Hawaii (1,278 transports, 38.4%) as the most frequent destination. The majority of evacuations were routine (72.5%) with only 4.9% urgent evacuations. Medical conditions (2,905 transports, 87%) accounted for the largest proportion of transports, surpassing injuries (442 transports, 13%). The most common reasons for medical transports were behavioral health (671 transports, 20.2%) and cardiovascular disease (505 transports, 15.1%).

Conclusions

The majority of medical evacuations in PACOM were because of medical illness with routine precedence category, mirroring the largely noncombat operations occurring across this large area.
Geographic Variation in Initiation of Evidence-based Psychotherapy Among Veterans With PTSD
Authors: Dufort Vincent M , Bernardy Nancy , Maguen Shira , Hoyt Jessica E , Litt Eric R , Patterson Olga V , Leonard Christine E , Shiner Brian
Published: December 2020

Introduction

The United States Department of Veterans Affairs (VA) has invested in implementation of evidence-based psychotherapy (EBP) for post-traumatic stress disorder (PTSD) for over a decade, resulting in slow but steady uptake of these treatments nationally. However, no prior research has investigated the geographic variation in initiation of EBP. Our objectives were to determine whether there is geographic variation in the initiation of EBP for PTSD in the VA and to identify patient and clinic factors associated with EBP initiation.

Materials and Methods

We identified VA patients with PTSD who had not received EBP as of January 2016 (N = 946,667) using retrospective electronic medical records data and determined whether they initiated EBP by December 2017. We illustrated geographic variation in EBP initiation using national and regional maps. Using multivariate logistic regression, we determined patient, regional, and nearest VA facility predictors of initiating treatment. This study was approved by the Veterans Institutional Review Board of Northern New England.

Results

Nationally, 4.8% (n = 45,895) initiated EBP from 2016 to 2017, and there was geographic variation, ranging from none to almost 30% at the 3-digit ZIP code level. The strongest patient predictors of EBP initiation were the negative predictor of being older than 65 years (OR = 0.47; 95% CI, 0.45-0.49) and the positive predictor of reporting military-related sexual trauma (OR = 1.96; 95% CI, 1.90-2.03). The strongest regional predictors of EBP initiation were the negative predictor of living in the Northeast (OR = 0.89; 95% CI, 0.86-0.92) and the positive predictor of living in the Midwest (OR = 1.47; 95% CI, 1.44-1.51). The only nearest VA facility predictor of EBP initiation was the positive predictor of whether the facility was a VA Medical Center with a specialized PTSD clinic (OR = 1.23; 95% CI, 1.20-1.26).

Conclusion

Although less than 5% of VA patients with PTSD initiated EBP, there was regional variation. Patient factors, region of residence, and nearest VA facility characteristics were all associated with whether patients initiated EBP. Strengths of this study include the use of national longitudinal data, while weaknesses include the potential for misclassification of PTSD diagnoses as well as the potential for misidentification of EBP. Our work indicates geographic areas where access to EBP for PTSD may be poor and can help target work improving access. Future studies should also assess completion of EBP for PTSD and related symptomatic and functional outcomes across geographic areas.