bluuebunny/crossref_metadata_2025 huggingface dataset:
Remote Sensing of Coral Reefs: Uncertainty in the Detection of Benthic Cover, Depth, and Water Constituents Imposed by Sensor Noise
Authors: Ackleson Steven G. , Moses Wesley J. , Montes Marcos J.
Published: December 2018

Coral reefs are biologically diverse and economically important ecosystems that are on the decline worldwide in response to direct human impacts and climate change. Ocean color remote sensing has proven to be an important tool in coral reef research and monitoring. Remote sensing data quality is driven by factors related to sensor design and environmental variability. This work explored the impact of sensor noise, defined as the signal to noise ratio (SNR), on the detection uncertainty of key coral reef ecological properties (bottom depth, benthic cover, and water quality) in the absence of environmental uncertainties. A radiative transfer model for a shallow reef environment was developed and Monte Carlo methods were employed to identify the range in environmental conditions that are spectrally indistinguishable from true conditions as a function of SNR. The spectrally averaged difference between remotely sensed radiance relative to sensor noise, ε, was used to quantify uncertainty in bottom depth, the fraction of benthic cover by coral, algae, and uncolonized sand, and the concentration of water constituents defined as chlorophyll, dissolved organic matter, and suspended calcite particles. Parameter uncertainty was found to increase with sensor noise (decreasing SNR) but the impact was non-linear. The rate of change in uncertainty per incremental change in SNR was greatest for SNR < 500 and increasing SNR further to 1000 resulted in only modest improvements. Parameter uncertainty was complicated by the bottom depth and benthic cover. Benthic cover uncertainty increased with bottom depth, but water constituent uncertainty changed inversely with bottom depth. Furthermore, water constituent uncertainty was impacted by the type of constituent material in relation to the type of benthic cover. Uncertainty associated with chlorophyll concentration and dissolved organic matter increased when the benthic cover was coral and/or benthic algae while uncertainty in the concentration of suspended calcite increased when the benthic cover was uncolonized sand. While the definition of an optimal SNR is subject to user needs, we propose that SNR of approximately 500 (relative to 5% Earth surface reflectance and a clear maritime atmosphere) is a reasonable engineering goal for a future satellite sensor to support research and management activities directed at coral reef ecology and, more generally, shallow aquatic ecosystems.
Performance Assessment of Dynamic Downscaling of WRF to Simulate Convective Conditions during Sagebrush Phase 1 Tracer Experiments
Authors: Bhimireddy Sudheer R. , Bhaganagar Kiran
Published: December 2018

Large-Eddy Simulations (LES) corresponding to four convective intensive observation periods of Sagebrush Phase 1 tracer experiment were conducted with realistic boundary conditions using Weather Research and Forecast model (WRF). Multiple nested domains were used to dynamically downscale the conditions from domain with grid size of 24 km to local scales with grid size of 150 m. Sensitivity analysis of mesoscale model was conducted using three boundary layer, three surface layer and two micro-physics schemes. Model performance was evaluated by comparing the surface meteorological variables and boundary layer height from the mesoscale runs and observed values during tracer experiment. Output from mesoscale simulations was used to drive the LES domains. Effect of vertical resolution and sub-grid scale parameterizations were studied by comparing the wind speed and direction profiles along with turbulent kinetic energy at two different heights. Atmospheric stability estimated using the Richardson number and shear exponent evaluated between 8- and 60-m levels was found to vary between weakly unstable to unstable. Comparing the wind direction standard deviations coupled with the wind speeds showed that the WRF-LES underestimated the wind direction fluctuations for wind speeds smaller than 3-ms − 1 . Based on the strengths of convection and shear, WRF-LES was able to simulate horizontal convection roll and convective cell type features.
A Homeostatic Model of Subjective Cognitive Decline
Authors: Mizuno Akiko , Ly Maria , Aizenstein Howard J.
Published: December 2018

Subjective Cognitive Decline (SCD) is possibly one of the earliest detectable signs of dementia, but we do not know which mental processes lead to elevated concern. In this narrative review, we will summarize the previous literature on the biomarkers and functional neuroanatomy of SCD. In order to extend upon the prevailing theory of SCD, compensatory hyperactivation, we will introduce a new model: the breakdown of homeostasis in the prediction error minimization system. A cognitive prediction error is a discrepancy between an implicit cognitive prediction and the corresponding outcome. Experiencing frequent prediction errors may be a primary source of elevated subjective concern. Our homeostasis breakdown model provides an explanation for the progression from both normal cognition to SCD and from SCD to advanced dementia stages.
BRCA Mutations and Breast Cancer Prevention
Authors: Kotsopoulos Joanne
Published: December 2018

Women who inherit a deleterious BRCA1 or BRCA2 mutation face substantially increased risks of developing breast cancer, which is estimated at 70%. Although annual screening with magnetic resonance imaging (MRI) and mammography promotes the earlier detection of the disease, the gold standard for the primary prevention of breast cancer remains bilateral mastectomy. In the current paper, I review the evidence regarding the management of healthy BRCA mutation carriers, including key risk factors and protective factors, and also discuss potential chemoprevention options. I also provide an overview of the key findings from the literature published to date, with a focus on data from studies that are well-powered, and preferably prospective in nature.
Ponatinib Inhibits Multiple Signaling Pathways Involved in STAT3 Signaling and Attenuates Colorectal Tumor Growth
Authors: Tan Fiona H. , Putoczki Tracy L. , Lou Jieqiong , Hinde Elizabeth , Hollande Frédéric , Giraud Julie , Stylli Stanley S. , Paradiso Lucia , Zhu Hong-Jian , Sieber Oliver M. , Luwor Rodney B.
Published: December 2018

Signal transducer and activator of transcription 3 (STAT3) signaling is a major driver of colorectal cancer (CRC) growth, however therapeutics, which can effectively target this pathway, have so far remained elusive. Here, we performed an extensive screen for STAT3 inhibitors among a library of 1167 FDA-approved agents, identifying Ponatinib as a lead candidate. We found that Ponatinib inhibits STAT3 activity driven by EGF/EGFR, IL-6/IL-6R and IL-11/IL-11R, three major ligand/receptor systems involved in CRC development and progression. Ponatinib was able to inhibit CRC migration and tumor growth in vivo. In addition, Ponatinib displayed a greater ability to inhibit STAT3 activity and mediated superior anti-proliferative efficacy compared to five FDA approved SRC and Janus Kinase (JAK) inhibitors. Finally, long-term exposure of CRC cells to Ponatinib, Dasatinib and Bosutinib resulted in acquired resistance to Dasatinib and Bosutinib occurring within six weeks. However, acquired resistance to Ponatinib was observed after long-term exposure of >4 months. Overall, our results identify a novel anti-STAT3 property of Ponatinib and thus, Ponatinib offers a potential therapeutic strategy for CRC.
Comparing the Efficiency of N-Doped TiO2 and N-Doped Bi2MoO6 Photo Catalysts for MB and Lignin Photodegradation
Authors: Rangel Ricardo , Cedeño Verónica Janneth , Espino Jaime , Bartolo-Pérez Pascual , Rodríguez-Gattorno Geonel , Alvarado-Gil Juan José
Published: December 2018

In this study, we tested the efficiency of nitrogen-doped titanium dioxide (N-TiO2) and nitrogen-doped bismuth molybdate (N-Bi2MoO6) compounds as photocatalysts capable of degrading methylene blue and lignin molecules under irradiation with ultraviolet (UV) and visible light (VIS). Moreover, we compared TiO2 and Bi2MoO6 catalysts with N-TiO2 and N-Bi2MoO6 compounds using chemical coprecipitation. The catalysts were prepared starting from Ti(OCH2CH2CH3)4, Bi(NO3)3·5H2O, and (NH4)6Mo7O24 reagents. N-doping was achieved in a continuous reflux system, using ethylene diamine as a nitrogen source. The resulting materials were characterized using Scanning Electron Microscopy (SEM), X-Ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). Additionally, we observed the decrease in particle size after processing the compounds in the reflux system. The results regarding photocatalytic degradation tests show a remarkable effect for nitrogen doped samples, achieving 90% of lignin degradation.
Application of Catalytic Wet Peroxide Oxidation for Industrial and Urban Wastewater Treatment: A Review
Authors: Rueda Márquez Juan José , Levchuk Irina , Sillanpää Mika
Published: December 2018

Catalytic wet peroxide oxidation (CWPO) is emerging as an advanced oxidation process (AOP) of significant promise, which is mainly due to its efficiency for the decomposition of recalcitrant organic compounds in industrial and urban wastewaters and relatively low operating costs. In current study, we have systemised and critically discussed the feasibility of CWPO for industrial and urban wastewater treatment. More specifically, types of catalysts the effect of pH, temperature, and hydrogen peroxide concentrations on the efficiency of CWPO were taken into consideration. The operating and maintenance costs of CWPO applied to wastewater treatment and toxicity assessment were also discussed. Knowledge gaps were identified and summarised. The main conclusions of this work are: (i) catalyst leaching and deactivation is one of the main problematic issues; (ii) majority of studies were performed in semi-batch and batch reactors, while continuous fixed bed reactors were not extensively studied for treatment of real wastewaters; (iii) toxicity of wastewaters treated by CWPO is of key importance for possible application, however it was not studied thoroughly; and, (iv) CWPO can be regarded as economically viable for wastewater treatment, especially when conducted at ambient temperature and natural pH of wastewater.
Determination of Optimum Concentration of Benzimidazole Improving the Cathodic Disbonding Resistance of Epoxy Coating
Authors: Nabavian Saghar , Naderi Reza , Asadi Najmeh
Published: December 2018

This study is aimed to evaluate the effect of concentrated benzimidazole (BIM) on the cathodic disbonding (CP) of an epoxy coating applied on steel substrate. For this purpose, the polymeric coatings, formulated with different concentrations of BIM (0 wt.%, 0.5 wt.%, 0.75 wt.%, and 1 wt.%, were subjected to the CP test at the potential of −1.2 V vs. Ag/AgCl during 24 h immersion in 3.5 wt.% NaCl solutions. The optimum formulation was found through taking advantage of the CP test results, FESEM/EDX, and EIS data. Moreover, a pull-off test was used to measure the wet adhesion strength. For insight into the inhibition function of the organic inhibitor, the behavior of steel in the sodium chloride solutions, with and without BIM, was compared using EIS and surface analysis.
CMCC: Misuse Resistant Authenticated Encryption with Minimal Ciphertext Expansion
Authors: Trostle Jonathan
Published: December 2018

In some wireless environments, minimizing the size of messages is paramount due to the resulting significant energy savings. We present CMCC (CBC-MAC-CTR-CBC), an authenticated encryption scheme with associated data (AEAD) that is also nonce misuse resistant. The main focus for this work is minimizing ciphertext expansion, especially for short messages including plaintext lengths less than the underlying block cipher length (e.g., 16 bytes). For many existing AEAD schemes, a successful forgery leads directly to a loss of confidentiality. For CMCC, changes to the ciphertext randomize the resulting plaintext, thus forgeries do not necessarily result in a loss of confidentiality which allows us to reduce the length of the authentication tag. For protocols that send short messages, our scheme is similar to Synthetic Initialization Vector (SIV) mode for computational overhead but has much smaller expansion. We prove both a misuse resistant authenticated encryption (MRAE) security bound and an authenticated encryption (AE) security bound for CMCC. We also present a variation of CMCC, CWM (CMCC With MAC), which provides a further strengthening of the security bounds.
Fault Classification of Axial and Radial Roller Bearings Using Transfer Learning through a Pretrained Convolutional Neural Network
Authors: Hemmer Martin , Van Khang Huynh , Robbersmyr Kjell , Waag Tor , Meyer Thomas
Published: December 2018

Detecting bearing faults is very important in preventing non-scheduled shutdowns, catastrophic failures, and production losses. Localized faults on bearings are normally detected based on characteristic frequencies associated with faults in time and frequency spectra. However, missing such characteristic frequency harmonics in a spectrum does not guarantee that a bearing is healthy, or noise might produce harmonics at characteristic frequencies in the healthy case. Further, some defects on roller bearings could not produce characteristic frequencies. To avoid misclassification, bearing defects can be detected via machine learning algorithms, namely convolutional neural network (CNN), support vector machine (SVM), and sparse autoencoder-based SVM (SAE-SVM). Within this framework, three fault classifiers based on CNN, SVM, and SAE-SVM utilizing transfer learning are proposed. Transfer of knowledge is achieved by extracting features from a CNN pretrained on data from the imageNet database to classify faults in roller bearings. The effectiveness of the proposed method is investigated based on vibration and acoustic emission signal datasets from roller bearings with artificial damage. Finally, the accuracy and robustness of the fault classifiers are evaluated at different amounts of noise and training data.
Values Education or Religious Education? An Alternative View of Religious Education in the Secular Age, the Case of Turkey
Authors: GENÇ Muhammet
Published: December 2018

Debates about the teaching of religion date back to the formation of the modern education system, when religion was first compartmentalized as a distinct subject within a broader curriculum. In many places, they continue to rage today. In Turkey, they are inextricably tied to the creation of the country’s system of secular public instruction in the 1920s and the transition to multi-party government in the 1940s. On 30 March 2012, Turkey passed a new law that revamped the country’s public educational system, mandating twelve years of instruction divided into three four-year periods (roughly corresponding to elementary, middle, and high school). This law led to the opening of many new religious schools—known as Imam-Hatip schools (i.e., schools for the training of imams and hatips, or preachers)—across the country, especially at the middle-school level. The number of students studying in these schools rose from 70,000 in 2002 to 1,300,000 after the new law. New elective courses on religion were also added to the curriculum, and curricular and extra-curricular religious-education activities offered by government-sponsored Islamic civil society organizations became more prevalent. All of this has reignited old debates about religious instruction in the country. This article begins with an overview of the history of secularism in Turkey. It then focuses on the history of religious education and the model of religious education in Turkey. It concludes with a discussion of how religious education centering on values education operates within the secular framework of public education in confessional and non-confessional formats.
Influences of Fracturing Fluid Injection on Mechanical Integrity of Cement Sheath under Four Failure Modes
Authors: Xu Honglin , Ma Tianshou , Peng Nian , Yang Bin
Published: December 2018

The significant decreased wellbore temperature and increased casing pressure during fracturing fluid injection present a big challenge for the mechanical integrity of cement sheath in fracturing wells. Based on the theories of elastic mechanics, thermodynamics, and a multi-layer composed thick-wall cylinder, this paper proposed a new mechanical model of cement sheath for fracturing wells, coupling pressure, and thermal loads, which consider the failure modes of de-bonding, radial cracking, disking, and shear failure. The radial nonuniform temperature change and the continuous radial stress and radial displacement at two interfaces have been considered. With the proposed model, the radial distributions of failure stress and the corresponding safety factor for cement sheath during fracturing fluid injection have been analyzed and compared under four failure modes. Results show that the decreased wellbore temperature will produce significant tri-axial tensile stress and induce cement failure of de-bonding, radial cracking, and disking. The increased casing pressure will significantly lower the risk of de-bonding but also aggravate radial cracking and shear failure. For integrity protection of cement sheath, increasing the injected fluid temperature, maintaining higher circulation pumping pressures, and adopting cement sheath with a low elasticity modulus have been suggested for fracturing wells.
Effects of Mooring Compliancy on the Mooring Forces, Power Production, and Dynamics of a Floating Wave Activated Body Energy Converter
Authors: Martinelli Luca , Zanuttigh Barbara
Published: December 2018

The paper aims at investigating the interactions between a floating wave energy device (WEC) and its mooring system under a variety of wave conditions (regular and irregular, perpendicular and oblique, ordinary and extreme). The analyzed WEC is the DEXA, a wave activated body point absorber, of the type that performs better when aligned to the incident wave direction. Two typologies of mooring systems were studied: for limited depths, the spread system, with a disposition of the lines that do not constrain the yaw movements; for large depths, the catenary anchor leg mooring (CALM) system. The spread system was experimentally investigated, including a realistic power take-off system, to capture non-linear behaviors and assess device motions, power production, and forces on mooring lines. The CALM system was numerically simulated, as mooring modelling is more reliable in deep waters and allows testing of a number of different configurations, by changing the number of the mooring lines and the mooring layout. The experiments showed that a reduction of the mooring compliancy increases the power production. The numerical simulations showed that a redundancy on the number of chains allows a better distribution of the loads, with advantages on reliability and costs.
Different Nitrate and Ammonium Ratios Affect Growth and Physiological Characteristics of Camellia oleifera Abel. Seedlings
Authors: Wang Rui , Chen Longsheng , Chen Jianjun , Chen Yongzhong , Zhang Zhen , Wang Xiangnan , Peng Yinghe , Peng Shaofeng , Li Anliang , Wei Xiangying
Published: December 2018

Camellia oleifera Abel., is an important woody plant, and its fruit contains high-quality edible oil. Production of C. oleifera has significantly expanded over the last 20 years in China. Due to the lack of appropriate information on nutrient management, its production has encountered low yield and low oil quality problems. As nitrogen (N) is an essential nutrient and the most abundant in C. oleifera tissues, the present study investigated effects of different ratios of nitrate (NO3−) and ammonium (NH4+) on the growth of a cultivar Xianglin 27 at the seedling stage. Uniform seedlings were grown in a soil-based substrate in containers and fertigated with solutions composed of six ratios of NO3− and NH4+, respectively for five months. Results showed that C. oleifera prefers both NO3− and NH4+ at a ratio of 1:1. Seedlings receiving this solution had the highest total N in leaves and total dry weight; elevated chrolophyll, soluble saccharide and protein contents as well as higher activities of peroxidase (POD), superoxide dismutase (SOD), nitrate reductase (NR), glutamine synthetase (GS), and glutamate synthase (GOGAT). Our study shows for the first time that N supply for producing C. oleifera should be an equal ratio of NO3− and NH4+.
Wildland Fire Science Literacy: Education, Creation, and Application
Authors: McGranahan Devan Allen , Wonkka Carissa L.
Published: December 2018

Wildland fire science literacy is the capacity for wildland fire professionals to understand and communicate three aspects of wildland fire: (1) the fundamentals of fuels and fire behavior, (2) the concept of fire as an ecological regime, and (3) multiple human dimensions of wildland fire and the socio-ecological elements of fire regimes. Critical to wildland fire science literacy is a robust body of research on wildland fire. Here, we describe how practitioners, researchers, and other professionals can study, create, and apply robust wildland fire science. We begin with learning and suggest that the conventional fire ecology canon include detail on fire fundamentals and human dimensions. Beyond the classroom, creating robust fire science can be enhanced by designing experiments that test environmental gradients and report standard data on fuels and fire behavior, or at least use the latter to inform models estimating the former. Finally, wildland fire science literacy comes full circle with the application of robust fire science as professionals in both the field and in the office communicate with a common understanding of fundamental concepts of fire behavior and fire regime.
Social, Environmental and Behavioral Determinants of Asthma Symptoms in Brazilian Middle School Students—A National School Health Survey (Pense 2012)
Authors: Ribeiro-Silva Rita C. , Malta Deborah C. , Rodrigues Laura C. , Ramos Dandara O. , Fiaccone Rosemeire L. , Machado Daiane B. , Barreto Maurício L.
Published: December 2018

Biological and psychosocial factors are recognized contributors to the worldwide burden of asthma. However, the relationship between psychosocial factors and asthma symptoms among students in low- and middle-income countries remains underexplored. We aimed to identify socioeconomic, environmental, psychosocial, family-related and lifestyle factors associated with the self-reporting of asthma symptoms in Brazilian adolescents. This is a cross-sectional study using data from the 2012 PeNSE survey (n = 109,104). We analyzed the following variables: socioeconomic conditions, demographic characteristics, lifestyle, family context and dynamics, psychosocial indicators, smoking, and exposure to violence. Our outcome variable was the self-report of asthma symptoms in the past 12 months. The prevalence of wheezing was 22.7% (21.5–23.9). After adjusting for sex, age and the variables from higher hierarchical levels, exposure to violence (feeling unsafe at school, being frequently bullied, being exposed to fights with firearms) and physical aggression by an adult in the family were the environmental factors that showed the strongest associations with self-reporting of asthma symptoms. For psychosocial indicators of mental health and social integration, feelings of loneliness and sleeping problems were the strongest factors, and among individual behavioral factors, the largest associations were found for tobacco consumption. Our findings were consistent with previous studies, showing an association between self-reported asthma symptoms and socio-economic status, family context and dynamics, psychosocial indicators of mental health, exposure to violence and social integration, as well as a sedentary lifestyle and tobacco use.
Changes in Smoking Behaviors following Exposure to Health Shocks in China
Authors: Wang Qing , Rizzo John A. , Fang Hai
Published: December 2018

Background: Evidence suggests that following major individual health shocks, smokers change their smoking behaviors. However, little is known about the association between spousal health shocks and smoking. This study examined the contemporaneous and long-term effects of individual and spousal health shocks on males’ smoking behaviors in China. Methods: This study employed a nation-wide data base from the 1991–2011 China Health and Nutrition Study. Random effects models were estimated to ascertain the impacts of health shocks on males’ smoking behavior. Smoking behaviors were measured by smoking status, smoking consumption and smoking cessation. Results: In the short term, respondents who incurred health shocks decreased their likelihood of smoking by 10%. In addition, health shocks decreased the likelihood of heavy smoking versus the combined moderate and light categories by 41.6%, and increased their likelihood of quitting by 85.3% for ever smokers. Spousal health shocks had no significant effects on individual smoking behaviors. The long-term effects were similar to the short term impacts. Conclusions: People changed their smoking behaviors in response to their own health experiences but not those of their spouses. Antismoking messages about the health effects on others are unlikely to influence individual smoking behaviors, unless individuals believed that they are personally vulnerable to smoking-related diseases.
Health-Promoting Food Pricing Policies and Decision-Making in Very Remote Aboriginal and Torres Strait Islander Community Stores in Australia
Authors: Ferguson Megan , O'Dea Kerin , Altman Jon , Moodie Marjory , Brimblecombe Julie
Published: December 2018

Aboriginal and Torres Strait Islander people living in remote communities in Australia experience a disproportionate burden of diet-related chronic disease. This occurs in an environment where the cost of store-purchased food is high and cash incomes are low, factors that affect both food insecurity and health outcomes. Aboriginal and Torres Strait Islander storeowners and the retailers who work with them implement local policies with the aim of improving food affordability and health outcomes. This paper describes health-promoting food pricing policies, their alignment with evidence, and the decision-making processes entailed in their development in community stores across very remote Australia. Semi-structured interviews were conducted with a purposive sample of retailers and health professionals identified through the snowball method, September 2015 to October 2016. Data were complemented through review of documents describing food pricing policies. A content analysis of the types and design of policies was undertaken, while the decision-making process was considered through a deductive, thematic analysis. Fifteen retailers and 32 health professionals providing services to stores participated. Subsidies and subsidy/price increase combinations dominated. Magnitude of price changes ranged from 5% to 25% on fruit, vegetables, bottled water, artificially sweetened and sugar sweetened carbonated beverages, and broadly used ‘healthy/essential’ and ‘unhealthy’ food classifications. Feasibility and sustainability were considered during policy development. Greater consideration of acceptability, importance, effectiveness and unintended consequences of policies guided by evidence were deemed important, as were increased involvement of Aboriginal and Torres Strait Islander storeowners and nutritionists in policy development. A range of locally developed health-promoting food pricing policies exist and partially align with research-evidence. The decision-making processes identified offer an opportunity to incorporate evidence, based on consideration of the local context.
Challenging Cognitive Demands at Work, Related Working Conditions, and Employee Well-Being
Authors: Meyer Sophie-Charlotte , Hünefeld Lena
Published: December 2018

In times of digitalized workplaces the extent of challenging cognitive demands at work is rising and employees increasingly have to manage new and unlearned tasks. Yet, these work characteristics have received little attention on how they relate to the worker’s well-being. Thus, we analyze associations between cognitive work demands—also in interaction with other job characteristics—and indicators of employee well-being. The analyses are based on the BIBB/BAuA Employment Survey 2018, a cross-section that is representative for the German working population and covers approximately 20,000 employed individuals. Ordinary least squares (OLS) regressions suggest that cognitive demands are associated with a higher probability of feeling fatigued. In contrast, the results with respect to the employees’ self-rated health status and job satisfaction are ambiguous, depending on which cognitive demand is considered. Overall, the findings indicate that cognitive demands might be related to both resource and demand, depending on the individual resources of employees.
Testing the Price of Healthy and Current Diets in Remote Aboriginal Communities to Improve Food Security: Development of the Aboriginal and Torres Strait Islander Healthy Diets ASAP (Australian Standardised Affordability and Pricing) Methods
Authors: Lee Amanda , Lewis Meron
Published: December 2018

Aboriginal and Torres Strait Islander peoples suffer higher rates of food insecurity and diet-related disease than other Australians. However, assessment of food insecurity in specific population groups is sub-optimal, as in many developed countries. This study tailors the Healthy Diets ASAP (Australian Standardised Affordability and Pricing) methods protocol to be more relevant to Indigenous groups in assessing one important component of food security. The resultant Aboriginal and Torres Strait Islander Healthy Diets ASAP methods were used to assess the price, price differential, and affordability of healthy (recommended) and current (unhealthy) diets in five remote Aboriginal communities. The results show that the tailored approach is more sensitive than the original protocol in revealing the high degree of food insecurity in these communities, where the current diet costs nearly 50% of disposable household income compared to the international benchmark of 30%. Sixty-two percent of the current food budget appears to be spent on discretionary foods and drinks. Aided by community store pricing policies, healthy (recommended) diets are around 20% more affordable than current diets in these communities, but at 38.7% of disposable household income still unaffordable for most households. Further studies in urban communities, and on other socioeconomic, political and commercial determinants of food security in Aboriginal and Torres Strait Islander communities appear warranted. The development of the tailored method provides an example of how national tools can be adapted to better inform policy actions to improve food security and help reduce rates of diet-related chronic disease more equitably in developed countries.
Hepatitis B Vaccination among 1999–2017 Birth Cohorts in Zhejiang Province: The Determinants Associated with Infant Coverage
Authors: Hu Yu , Chen Yaping , Wang Ying , Liang Hui
Published: December 2018

This study aimed to investigate the coverage of hepatitis B vaccine (Hep B) and its completeness and timeliness for birth cohorts from 1999 to 2017 in Zhejiang province, East China. Demographic characteristics and vaccination records of Hep B of children born from 1 January 1999 to 31 June 2017 were extracted from the Zhejiang provincial immunization information system. The timeliness of the first dose of Hep B (Hep B1) was defined as the proportion of children who received the Hep B1 within 24 h after birth among the target population. The completeness of Hep B was defined as the proportion of children who completed the three-dose series of Hep B before 7 years of age. The demographic characteristics of the target population were described. The coverage of each dose of Hep B, the timeliness of Hep B1, and the completeness of Hep B for each birth cohort were described. A logistic regression model was applied to detect the determinants of the timeliness of Hep B1 and the completeness of Hep B vaccination. The coverage of Hep B1 increased from 90.3% to 98.3%, the coverage of Hep B2 increased from 88.8% to 96.1%, and the coverage of Hep B3 increased from 86.4% to 94.2%. The timeliness of Hep B1 increased from 80.3% to 91.3%. The completeness of Hep B increased from 81.3% to 91.5%. The determinants of timeliness of Hep B1 included children’s delivery place, immigration status, maternal education level, and economic development level of resident area. The determinants of completeness of Hep B included children’s delivery place, immigration status, maternal education level, economic development level of resident area, maternal occupation, and frequency of vaccination service. Zhejiang province had achieved significant improvements in the timely administration of Hep B1 and the completeness of Hep B. To accelerate progress toward additional reductions in the transmission of hepatitis B virus, further efforts need to be focused on improving the timeliness of Hep B1 vaccination and reducing the drop-outs among disadvantaged children with the risk factors identified in this study.
Comparison of Independent Component Analysis, Principal Component Analysis, and Minimum Noise Fraction Transformation for Tree Species Classification Using APEX Hyperspectral Imagery
Authors: Dabiri Zahra , Lang Stefan
Published: December 2018

Hyperspectral imagery provides detailed spectral information that can be used for tree species discrimination. The aim of this study is to assess spectral–spatial complexity reduction techniques for tree species classification using an airborne prism experiment (APEX) hyperspectral image. The methodology comprised the following main steps: (1) preprocessing (removing noisy bands) and masking out non-forested areas; (2) applying dimensionality reduction techniques, namely, independent component analysis (ICA), principal component analysis (PCA), and minimum noise fraction transformation (MNF), and stacking the selected dimensionality-reduced (DR) components to create new data cubes; (3) super-pixel segmentation on the original image and on each of the dimensionality-reduced data cubes; (4) tree species classification using a random forest (RF) classifier; and (5) accuracy assessment. The results revealed that tree species classification using the APEX hyperspectral imagery and DR data cubes yielded good results (with an overall accuracy of 80% for the APEX imagery and an overall accuracy of more than 90% for the DR data cubes). Among the classification results of the DR data cubes, the ICA-transformed components performed best, followed by the MNF-transformed components and the PCA-transformed components. The best class performance (according to producer’s and user’s accuracy) belonged to Picea abies and Salix alba. The other classes (Populus x (hybrid), Alnus incana, Fraxinus excelsior, and Quercus robur) performed differently depending on the different DR data cubes used as the input to the RF classifier.
High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines
Authors: Wang Shixiong , Singh Sachin Kumar , Katika Madhumohan R. , Lopez-Aviles Sandra , Hurtado Antoni
Published: December 2018

Forkhead box A1 (FOXA1) belongs to the forkhead class transcription factor family, playing pioneering function for hormone receptors in breast and prostate cancers, and mediating activation of linage specific enhancers. Interplay between FOXA1 and breast cancer specific signaling pathways has been reported previously, indicating a regulation network on FOXA1 in breast cancer cells. Here in this study, we aimed to identify which are the proteins that could potentially control FOXA1 function in breast cancer cell lines expressing different molecular markers. We first established a luciferase reporter system reflecting FOXA1 binding to DNA. Then, we applied high throughput chemical screening of multiple protein targets and mass spectrometry in breast cancer cell lines expressing different molecular markers: ER positive/HER2 negative (MCF-7), ER positive/HER2 positive (BT474), and ER negative/HER2 positive (MDA-MB-453). Regardless of estrogen receptor status, HER2 (human epidermal growth factor receptor 2) enriched cell lines showed similar response to kinase inhibitors, indicating the control of FOXA1 by cell signaling kinases. Among these kinases, we identified additional receptor tyrosine kinases and cyclin-dependent kinases as regulators of FOXA1. Furthermore, we performed proteomics experiments from FOXA1 inmunoprecipitated protein complex to identify that FOXA1 interacts with several proteins. Among all the targets, we identified cyclin-dependent kinase 1 (CDK1) as a positive factor to interact with FOXA1 in BT474 cell line. In silico analyses confirmed that cyclin-dependent kinases might be the kinases responsible for FOXA1 phosphorylation at the Forkhead domain and the transactivation domain. These results reveal that FOXA1 is potentially regulated by multiple kinases. The cell cycle control kinase CDK1 might control directly FOXA1 by phosphorylation and other kinases indirectly by means of regulating other proteins.
Brain-Derived Neurotrophic Factor in Central Nervous System Myelination: A New Mechanism to Promote Myelin Plasticity and Repair
Authors: Fletcher Jessica L. , Murray Simon S. , Xiao Junhua
Published: December 2018

Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development and plasticity in both health and disease. Recent studies using mutant mice to selectively manipulate BDNF signalling in desired cell types, in combination with animal models of demyelinating disease, have demonstrated that BDNF not only potentiates normal central nervous system myelination in development but enhances recovery after myelin injury. However, the precise mechanisms by which BDNF enhances myelination in development and repair are unclear. Here, we review some of the recent progress made in understanding the influence BDNF exerts upon the myelinating process during development and after injury, and discuss the cellular and molecular mechanisms underlying its effects. In doing so, we raise new questions for future research.
Towards Porous Silicon Oxycarbide Materials: Effects of Solvents on Microstructural Features of Poly(methylhydrosiloxane)/Divynilbenzene Aerogels
Authors: Aguirre-Medel Susana , Jana Prasanta , Kroll Peter , Sorarù Gian Domenico
Published: December 2018

We investigate the impact of solvents on the microstructure of poly(methylhydrosiloxane)/divinylbenzene (PMHS/DVB) aerogels. The gels are obtained in highly diluted conditions via hydrosilylation reaction of PMHS bearing Si-H groups and cross-linking it with C=C groups of DVB. Polymer aerogels are obtained after solvent exchange with liquid CO2 and subsequent supercritical drying. Samples are characterized using microscopy and porosimetry. Common pore-formation concepts do not provide a solid rationale for the observed data. We postulate that solubility and swelling of the cross-linked polymer in various solvents are major factors governing pore formation of these PMHS/DVB polymer aerogels.
Effects of the Mg/Si Ratio on Microstructure, Mechanical Properties, and Precipitation Behavior of Al–Mg–Si–1.0 wt %-Zn Alloys
Authors: Li Yong , Gao Guanjun , Wang Zhaodong , Di Hongshuang , Li Jiadong , Xu Guangming
Published: December 2018

Aluminum alloys are widely used as first-choice materials for lightweight automotive applications. It is important that an alloy have a balance between strength and formability. In this study, the alloys were melted, cast, hot rolled, and cold rolled into 1 mm-thick sheets. The microstructure, mechanical properties, and precipitation behavior of Al–Mg–Si–1.0 wt %-Zn alloys with Mg/Si ratios of 0.5, 1, and 2 after solution treatment were studied using optical and electron microscopy, a tensile test, the Vickers hardness test, and differential scanning calorimetry. The results showed that a high density and number of Al–Fe–Si particles were observed in the matrix, thus causing the formation of more homogeneous and smaller recrystallized grains after treatment with the solution. In addition, a higher volume fraction of cubeND and P-types texture components formed during solution treatment. Also, a high r value and excellent deep drawability were achieved in the medium-Mg/Si-ratio alloy. The formation of denser strengthening precipitates led to a better paint-bake hardening effect in comparison with the other two alloys. Furthermore, the precipitation kinetics were enhanced by the addition of Si, and the addition of Zn did not alter the precipitation sequence of the Al–Mg–Si alloy. The dual-phase strengthening effect was not achieved in the studied alloys during paint-bake treatment at 175 °C.
Progress on the Synthesis and Application of CuSCN Inorganic Hole Transport Material in Perovskite Solar Cells
Authors: Matebese Funeka , Taziwa Raymond , Mutukwa Dorcas
Published: December 2018

P-type wide bandgap semiconductor materials such as CuI, NiO, Cu2O and CuSCN are currently undergoing intense research as viable alternative hole transport materials (HTMs) to the spiro-OMeTAD in perovskite solar cells (PSCs). Despite 23.3% efficiency of PSCs, there are still a number of issues in addition to the toxicology of Pb such as instability and high-cost of the current HTM that needs to be urgently addressed. To that end, copper thiocyanate (CuSCN) HTMs in addition to robustness have high stability, high hole mobility, and suitable energy levels as compared to spiro-OMeTAD HTM. CuSCN HTM layer use affordable materials, require short synthesis routes, require simple synthetic techniques such as spin-coating and doctor-blading, thus offer a viable way of developing cost-effective PSCs. HTMs play a vital role in PSCs as they can enhance the performance of a device by reducing charge recombination processes. In this review paper, we report on the current progress of CuSCN HTMs that have been reported to date in PSCs. CuSCN HTMs have shown enhanced stability when exposed to weather elements as the solar devices retained their initial efficiency by a greater percentage. The efficiency reported to date is greater than 20% and has a potential of increasing, as well as maintaining thermal stability.
Metal Oxide Thin-Film Heterojunctions for Photovoltaic Applications
Authors: Nordseth Ørnulf , Kumar Raj , Bergum Kristin , Fara Laurentiu , Dumitru Constantin , Craciunescu Dan , Dragan Florin , Chilibon Irinela , Monakhov Edouard , Foss Sean Erik , Svensson Bengt Gunnar
Published: December 2018

Silicon-based tandem solar cells incorporating low-cost, abundant, and non-toxic metal oxide materials can increase the conversion efficiency of silicon solar cells beyond their conventional limitations with obvious economic and environmental benefits. In this work, the electrical characteristics of a metal oxide thin-film heterojunction solar cell based on a cuprous oxide (Cu2O) absorber layer were investigated. Highly Al-doped n-type ZnO (AZO) and undoped p-type Cu2O thin films were prepared on quartz substrates by magnetron sputter deposition. The electrical and optical properties of these thin films were determined from Hall effect measurements and spectroscopic ellipsometry. After annealing the Cu2O film at 900 °C, the majority carrier (hole) mobility and the resistivity were measured at 50 cm2/V·s and 200 Ω·cm, respectively. Numerical modeling was carried out to investigate the effect of band alignment and interface defects on the electrical characteristics of the AZO/Cu2O heterojunction. The analysis suggests that the incorporation of a buffer layer can enhance the performance of the heterojunction solar cell as a result of reduced conduction band offset.
Field Induced Slow Magnetic Relaxation in a Non Kramers Tb(III) Based Single Chain Magnet
Authors: Kharwar Ajit Kumar , Mondal Arpan , Konar Sanjit
Published: December 2018

Herein, we report a novel Tb(III) single chain magnet with the chemical formulae [Tb(μ-OH2)(phen)(μ-OH)(nb)2]n by using 4-nitrobenzoic acid (Hnb) and 1,10-phenanthroline (phen) as ligand system. The single-crystal X-ray diffraction reveals that 4-nitrobenzoic acid acts as a monodentate ligand, water and hydroxyl ions are the bridging ligand and the phen serves as a bidentate chelating ligand. The static magnetic susceptibility measurement (from 2 K to 300 K) shows ferromagnetic interaction at very low temperature (below 6 K). The alternating current (AC) susceptibility data of the complex show temperature and frequency dependence under an applied 2000 Oe DC (direct current) field. The phen moiety behaves as an antenna and enables the complex to show the green light fluorescence emission by absorption-energy transfer-emission mechanism. To calculate the exchange interaction, broken symmetry density functional theory (BS-DFT) calculations have been performed on a model compound which also reveals weak ferromagnetic interaction. Ab initio calculations reveals the anisotropic nature (gz = 15.8, gy, gy = 0) of the metal centre and the quasi doublet nature of ground state with small energy gap and that is well separated from the next excited energy state.
Mean Values of Products of L-Functions and Bernoulli Polynomials
Authors: Bayad Abdelmejid , Kim Daeyeoul
Published: December 2018

Let m 1 , ⋯ , m r be nonnegative integers, and set: M r = m 1 + ⋯ + m r . In this paper, first we establish an explicit linear decomposition of: ∏ i = 1 r B m i ( x ) m i ! in terms of Bernoulli polynomials B k ( x ) with 0 ≤ k ≤ M r . Second, for any integer q ≥ 2 , we study the mean values of the Dirichlet L-functions at negative integers: ∑ χ 1 , ⋯ , χ r ( mod q ) ; χ 1 ⋯ χ r = 1 ∏ i = 1 r L ( − m i , χ i ) where the summation is over Dirichlet characters χ i modulo q. Incidentally, a part of our work recovers Nielsen’s theorem, Nörlund’s formula, and its generalization by Hu, Kim, and Kim.