bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship and Predictive Value of Netrin-1 Expression and Ultrasonic Blood Flow Parameters with the Severity of Cervical Intraepithelial Neoplasia
Authors: Liu Bo , Wei Ling , Wu Lirui , Wang Huiying , Wang Hongli , Yu Qian
Published: October 2024

Objective: To analyze the relationship and predictive value of Netrin-1 expression and ultrasonic blood flow parameters with the severity of cervical intraepithelial neoplasia (CIN). Methods: The receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of Netrin-1 expression and ultrasonic blood flow parameters for the severity of cervical intraepithelial neoplasia. Results: FI, VI, and VFI levels increased sequentially, and the differences in levels between grade II, III patients, and the control group were statistically significant (P < 0.05). Netrin-1 was negatively correlated with ultrasonic blood flow parameters FI, VI, and VFI (r = -0.287, -0.309, -0.298, P < 0.05). The results of multifactorial logistic regression analysis showed that Netrin-1 positivity was a protective factor for CIN III lesions, while FI, VI, and VFI were risk factors for CIN III lesions. The AUC area of Netrin-1 was 0.712, with a sensitivity and specificity of 76.4% and 79.5%, respectively, which were higher than those of other indicators (P < 0.05). Conclusion: Netrin-1 is under-expressed in CIN patients, while ultrasonic blood flow parameters FI, VI, and VFI are over-expressed, and both are closely related to the severity of the patient's lesions. Netrin-1 is negatively correlated with ultrasonic blood flow parameters FI, VI, and VFI. Netrin-1 positivity is a protective factor for CIN III lesions, while FI, VI, and VFI are risk factors for CIN III lesions. The expression levels of both have a certain predictive guiding role in the early screening, diagnosis, and prevention of cervical cancer.
Modeling of Electric Field and Dielectrophoretic Force in a Parallel-plate Cell-separation Device with an Electrode Lid and Analytical Formulation Using Fourier Series
Authors: Nishikawa Daiki , Seki Yoshinori , Tada Shigeru
Published: October 2024

Dielectrophoresis (DEP) cell-separation technology is an effective means of separating rare cells. To develop highly efficient cell-separation devices, detailed analysis of the nonuniform electric field’s intensity distribution within the device is needed, as it affects separation performance. Here we analytically expressed the distributions of the electric field and DEP force in a parallel-plate cell-separation DEP device by employing electrostatic analysis through the Fourier series method. The solution was approximated by extrapolating a novel approximate equation as a boundary condition for the potential between adjacent fingers of interdigitated electrodes and changed the underlying differential equation into a solvable form. The distributions of the potential and electric fields obtained by the analytical solution were compared with those from numerical simulations using finite element method software to verify their accuracy. The results showed excellent agreement. Three-dimensional fluorescence imaging analysis used live non-tumorigenic human mammary (MCF10A) cells. The distribution of cell clusters adsorbed on the interdigitated electrodes was compared with the analytically obtained distribution of the DEP force, and the mechanism underlying cell adsorption on the electrode surface was discussed. Furthermore, parametric analysis using the width and spacing of these electrodes as variables revealed that spacing is crucial for determining DEP force. The results showed that, by optimizing cell-separation devices using interdigitated electrodes, adjusting electrode spacing significantly enhances device performance.
Oxidative Stress and Placental Pathogenesis: A Contemporary Overview on Potential Biomarkers and Emerging Therapeutics
Authors: Vornic Ioana , Buciu Victor , Furau Cristian George , Gaje Pusa Nela , Ceausu Raluca Amalia , Dumitru Cristina-Stefania , Barb Alina Cristina , Novacescu Dorin , Cumpanas Alin Adrian , Latcu Silviu Constantin , Cut Talida Georgiana , Zara Flavia
Published: October 2024

Oxidative stress (OS) plays a crucial role in placental pathogenesis and pregnancy-related complications. This review explores OS's impact on placental development and function, focusing on novel biomarkers for early detection of at-risk pregnancies and emerging therapeutic strategies. We analyzed recent research on OS in placental pathophysiology, examining its sources, mechanisms, and effects. While trophoblast invasion under low-oxygen conditions and hypoxia-induced OS regulate physiological placental development, excessive OS can lead to complications like miscarriage, preeclampsia, and intrauterine growth restriction. Promising OS biomarkers, including malondialdehyde, 8-isoprostane, and the sFlt-1/PlGF ratio, show potential for early detection of pregnancy complications. Therapeutic strategies targeting OS, such as mitochondria-targeted antioxidants, Nrf2 activators, and gasotransmitter therapies, demonstrate encouraging preclinical results. However, clinical translation remains challenging. Future research should focus on validating these biomarkers in large-scale studies and developing personalized therapies to modulate placental OS. Emerging approaches like extracellular vesicle-based therapies and nanomedicine warrant further investigation for both diagnostic and therapeutic applications in pregnancy-related complications. Integrating OS biomarkers with other molecular and cellular markers offers improved potential for early identification of at-risk pregnancies.
Identification of Three Novel O-Linked Glycans in the Envelope Protein of Tick-Borne Encephalitis Virus
Authors: Könighofer Ebba , Mirgorodskaya Ekaterina , Nyström Kristina , Stiasny Karin , Kärmander Ambjörn , Bergström Tomas , Nordén Rickard
Published: October 2024

Tick-borne encephalitis virus is a pathogen endemic to northern Europe and Asia, transmitted through bites from infected ticks. It is a member of the Flaviviridae family, possesses a positive-sense, single-stranded RNA genome encoding a polypeptide that is processed into seven non-structural and three structural proteins, including the envelope (E) protein. The glycosylation of the E protein, a single N-linked glycan at position N154, plays a critical role in viral infectivity and pathogenesis. Here, we dissected the entire glycosylation profile of the E protein using liquid chromatography tandem mass spectrometry and identified three novel O-linked glycans which were found at relatively low frequency. One of the O-linked glycans was positioned close to the highly conserved N-linked glycan site and structural analysis indicated that it may be of relevance for viral maturation. The N154 site was found to be glycosylated with a high frequency, containing oligomannose or complex-type structures, some of which are fucosylated. An unusually high portion of oligomannose N-linked glycan structures exhibited compositions that are normally observed on proteins while they are translocated from the endoplasmic reticulum to the trans golgi network, suggesting disruption of the glycan processing pathway in the infected cells from which the E protein was obtained.
Detection and Quantification of SARS-CoV-2 and Influenza Viruses in Wastewater Treatment Plants Located in Ticino Region (Switzerland)
Authors: Mauri Federica , Caminada AnnaPaola , Pianta Elisa , Zezza Giulia , Tonolla Mauro , Guidi Valeria
Published: October 2024

Wastewater-based epidemiology (WBE) is a promising approach that has been used to monitoring the exposure to pathogens and understanding the status of disease outbreaks in defined population groups. Viral RNAs of SARS-Cov-2 and influenza A and B were detected and quantified by two commercial kits in three wastewater treatment plants (WWTP) selected in different regions of Canton Ticino (Switzerland). We have monitored the presence of SARS-CoV-2 during two big waves of pandemic, from March 2021 until June 2023, when number of confirmed cases and tests decreased. The presence of influenza A and B viruses was investigated from October 2022 to June 2023. We confirmed the presence of SARS-CoV-2 and influenza A and B in all the WWTP monitored; RNA concentration in wastewater could be correlated with clinical cases confirming that WBE is a powerful tool to monitor diseases dissemination supporting the management of an epidemic.
Optimizing Euclidean Distance Computation
Authors: Mussabayev Rustam
Published: October 2024

In this paper, we present a comparative analysis of seventeen different approaches to optimizing Euclidean distance computations, a core mathematical operation that plays a critical role in a wide range of algorithms, particularly in machine learning and data analysis. The Euclidean distance, being a computational bottleneck in large-scale optimization problems, requires efficient computation techniques to improve the performance of various distance-dependent algorithms. To address this, several optimization strategies can be employed to accelerate distance computations. From spatial data structures and approximate nearest neighbor algorithms to dimensionality reduction, vectorization, and parallel computing, various approaches exist to accelerate Euclidean distance computation in different contexts. Such approaches are particularly important for speeding up key machine learning algorithms like K-means and K-nearest neighbors (KNN). By understanding the trade-offs and assessing the effectiveness, complexity, and scalability of various optimization techniques, our findings help practitioners choose the most appropriate methods for improving Euclidean distance computations in specific contexts. These optimizations enable scalable and efficient processing for modern data-driven tasks, directly leading to reduced energy consumption and a minimized environmental impact.
The Use of Artificial Intelligence (AI) in the Management of Medical Rehabilitation Programs
Authors: Luca Catalina , Onu Ilie , Sardaru Dragos Petrica , Matei Daniela Viorelia , Robert Fuior , Corciova Calin-Petru
Published: October 2024

The revolution of physiotherapy is achieved by the application of artificial intelligence (AI) in medical rehabilitation programs. While the integration of virtual reality (VR) and robotics has already marked significant strides in the industry, AI is taking patient rehabilitation to new heights. The integration of AI, VR and robotics in physiotherapy linked to a significant leap forward in patient rehabilitation. These technologies not only increase the effectiveness of the treatment, but also make it more accessible and attractive. In this article, we propose to study the use of AI in the management of medical rehabilitation programs, and we present a comprehensive survey of the latest empirical studies, highlighting AI-based technologies that facilitate the rehabilitation process, trying to demonstrate that the integration of AI in medical rehabilitation programs offers a transformative approach to patient care.
CD2K: An Accessible Framework for Leveraging Public Omics Data in Biomedical Research Training
Authors: Rinchai Darawan , Garand Mathieu , Toufiq Mohammed , Kabeer Basirudeen Syed Ahamed , Marr Nico , Chaussabel Damien
Published: October 2024

The exponential growth of publicly available omics data presents both an opportunity and a challenge for biomedical researchers, particularly those in low- and middle-income countries (LMICs). The Collective Omics Data to Knowledge (CD2K) initiative aims to address this challenge by providing an accessible framework for biomedical research training. This review describes the development and implementation of the CD2K program, which comprises three core modules: COD1 (reductionist interpretation of collective omics data), COD2 (creation of curated dataset collections), and COD3 (re-analysis of omics data on a global scale). The CD2K approach emphasizes the reuse and reinterpretation of public data, integrating literature mining and emerging technologies like Large Language Models (LLMs). A key feature of the program is its focus on accessibility, designed to make the exploitation of large-scale datasets amenable to researchers without extensive data science skills. The curriculum aims to equip trainees with a range of skills, from basic data interpretation to more advanced bioinformatics analysis, with an emphasis on producing tangible outputs such as peer-reviewed publications, which directly address career development needs. The CD2K initiative has involved researchers from multiple institutions across several countries, resulting in several publications and publicly available dataset collections. While still in its early stages, the program shows promise in providing a structured framework for leveraging public omics data in biomedical research. This review also discusses the current limitations of the CD2K approach and ongoing efforts to expand its reach. By offering an accessible model for building research capacity, the CD2K initiative represents a step towards fostering data-driven discovery in global biomedical research, particularly in resource-limited settings.
Individual Effects of Polymorphisms Linked to PCOS in Colombian Women: A Case-Control Exploratory Study
Authors: Alarcón-Granados Maria Camila , Moreno-Ortíz Harold , Ferrebuz-Cardozo Atilio Junior , Camargo-Villalba Gloria Eugenia , Forero-Castro Maribel
Published: October 2024

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in premenopausal women. Although the etiology of PCOS remains uncertain, the role of single nucleotide polymor-phisms (SNPs) in its pathogenesis has been extensively described. The second large genome-wide association study (GWAS) conducted in a Chinese population identified that variants in the INSR (rs2059807), TOX3 (rs4784165), YAP1 (rs1894116), HMGA2 (rs2272046), and ERBB3 (rs2292239) genes are associated with PCOS. In this exploratory study, we evaluated the genetic contribution of five polymorphisms in these genes in a sample of Colombian women. Forty-nine control women and forty-nine women with PCOS were included. Genotypic and allelic frequencies were calcu-lated under different inheritance models, and genotype/phenotype analysis was performed. We found that rs4784165-TOX3 was negatively associated with PCOS risk. Additionally, the GG+AA genotypes at rs2059807-INSR were linked to higher fasting blood glucose levels, while the GA genotype was associated with a greater number of total antral follicles. The AC genotype at rs2272046-HMGA2 was associated with older age and larger total ovarian volume. This is the first pilot study in Colombia to explore the relationship between these gene polymorphisms and PCOS, providing the first insights for the country.
PAC-1 Agonist Maxadilan Reduces Atherosclerotic Lesions in Hypercholesterolemic ApoE Deficient Mice
Authors: Mey Lilli , Bonaterra Gabriel A , Hoffmann Joy , Schwarzbach Hans , Schwarz Anja , Eiden Lee E , Weihe Eberhard , Kinscherf Ralf
Published: October 2024

Recent studies with ApoE knockout (ApoE-/-) mice deficient for PACAP (pituitary adenylate cyclase-activating polypeptide) or its receptor PAC1 provide evidence for a possible involve-ment of immune- and vasoregulatoy PACAP signaling at the PAC1 receptor in atherogenesis and plaque associated vascular inflammation. Therefore, we tested the PAC1 receptor agonist Maxadilan and the PAC1 selective antagonist M65 on plaque development and lumen stenosis in the ApoE-/- atherosclerosis model for possible anti-atherogenic effects. Adult male ApoE-/- mice were fed a cholesterol-enriched diet (CED) or standard chow (SC) treat-ed with Maxadilan, M65 or Sham. Effects of treatment on atherosclerotic plaques, lumen stenosis, apoptosis and pro-inflammatory signatures were analyzed in the brachiocephalic trunk (BT). The percentage of Maxadilan treated mice exhibiting plaques under SC and CED was lower than that of Sham or M65 treatment indicating opposite effects of Maxadilan and M65. Maxadilan ap-plication inhibited lumen stenosis under SC and CED compared to Sham. In spite of significantly increased cholesterol levels, lumen stenosis of Maxadilan-treated mice was similar under CED and SC. In contrast, M65 under SC or CED did not reveal a significant influence on lumen steno-sis. Maxadilan significantly reduced the TNF-α+ area in the plaques under CED, but not under SC. In contrast, the IL-1β+ area was reduced after Maxadilan treatment under SC, but remained unchanged under CED compared to Sham. Maxadilan reduced the caspase-3+ area in the media under both SC and CED without affecting lipid content in plaques. Despite persisting hypercholesterolemia, Maxadilan reduces lumen stenosis, apoptosis and TNF-α driven inflammation. Our data suggest that Maxadilan provides atheroprotection by act-ing downstream of cholesterol-induced vascular inflammation. This implicates the potential of PAC1-specific agonist drugs against atherosclerosis even beyond statins and PCSK-9.
Interaction of Silicon-Phosphorus: The Unexplored Connection in the Soil Ecosystem
Authors: Barão Lúcia , Teixeira Ricardo F.M.
Published: October 2024

Phosphorus (P) is an essential element in food production, but it is often largely unavailable for plants as it persists in soils in immobilized forms. Farmers have been using P fertilizers extensively to overcome this unavailability, leading to the exhaustion of non-renewable deposits of phosphorite, rising fertilizers prices and causing several environmental impacts such as eutrophication. Its large-scale utilization is also inefficient since most of the added P becomes quickly unavailable for the plants. Therefore, farming solutions that improve P uptake, P use efficiency of plants and P mobilization in soils are highly important. In this narrative review, we summarized and explored the link between the Silicon (Si) and P cycles in soils. Silicon is quasi-essential for plants, and it has been established that its presence in soil and uptake by plants has several benefits, especially in toxic and nutrient-deficient conditions. Here, we established that Si in soils can affect crop production in P-deficient conditions through: 1) the pH effect – Si improves organic matter decomposition and decreases Al3+ availability; the Si uptake effect – the deposited Si in the plant improves its photosynthetic performance, improves the root ability to uptake P, improves organic matter decomposition and increases P/Mn ration in plant, improving P use; and 3) the Si soil effect – Si stimulates phosphorite rocks weathering and competes with P for the binding places at the surface of Ak and Fe hydroxides, releasing P into soil solution. This positive effect of Si on P mobilization in soils and consequent use by crops should be further disseminated to farmers and other relevant stakeholders.
No más normalidad
Authors: Gallarzo Medina Manuel
Published: October 2024

Para nadie ha sido fácil renunciar a la normalidad, porque la normalidad no sorprende, es la falta de esta lo que nos toma por desconcierta. O dicho en palabras de Vincent Van Gogh, la normalidad es un camino pavimentado por el que es fácil caminar, pero nunca habrá flores en él.
Esperanza
Authors: Frómeta Rodríguez Omar
Published: October 2024

Han cambiado las dinámicas habituales, la cotidianidad, las rutinas de sociabilidad ahora son diferentes. El mundo nos impone la búsqueda de nuevas alternativas de adaptabilidad, en los tiempos actuales, los cuales se tornan convulsos, ante la llegada de un enemigo común: un virus pandémico que intenta alejar la sonrisa de los rostros.
¡Quiero ver a mis abuelos!
Authors: Montoya Ravelo Eiran
Published: October 2024

Hay que hacer un cohete para que se lleve al Coronavirus.
¡Somos ATSE, somos UACJ!
Authors: Jácome Santos Miguel Ángel
Published: October 2024

El siguiente texto, es una breve descripción de la Asociación de Trabajadoras(es) Sociales Egresados de la UACJ, la cual tiene sus orígenes desde 1994 y desde entonces ha realizado diversas acciones para promover el formalecimiento gremial de las y los egresados en Trabajo Social a nivel local, es decir, en Ciudad Juárez, Chihuahua. En este texto solo se habla de manera muy sintetizada sobre lo que la ATSE-UACJ ha realizado a lo largo de estos 25 años como una asociación derivada de la Universidad Autónoma de Ciudad Juárez.
Ideas sobre la buena vida entre los rarámuri de Aboreachi
Authors: Loera González Juan Jaime
Published: October 2024

Este breve texto expone algunas ideas reunidas en diversos encuentros etnográficos vividos durante temporadas de campo antropológico en la Sierra Tarahumara en un periodo de varios años. En concreto, rescato reflexiones y argumentos surgidos en el contexto de mi investigación doctoral, uno de cuyos objetivos fue documentar y analizar las diversas nociones de bienestar dentro de dos localidades rarámuri: Aboreachi y Laguna de Aboreachi, ambas ubicadas en el municipio de Guachochi, en la región tarahumara del estado de Chihuahua, al norte de México.
Biomechanical Optimization and Reinforcement Learning Provide Insights into Ankle-to-Hip Strategy Transitions in Human Postural Control
Authors: Hong Seongwoong , Park Sukyung
Published: October 2024

Human postural control strategies, categorized as ankle or hip strategies, adapt to varying perturbation magnitudes and support surface sizes. While numerous studies have characterized these strategies, few have explored the underlying mechanisms driving the transition from ankle to hip strategy. This study investigated whether postural strategy transitions can be explained through an optimization mechanism incorporating biomechanical constraints. We analyzed postural strategy changes in human responses to backward perturbations and developed a reinforcement learning (RL)-based optimization model. The biomechanical constraint was defined as the center of pressure (CoP) range limitation to the metatarsal joint. The control objective function featured a novel CoP constraint penalty, complemented by terms for upright posture recovery and control effort minimization. The RL-based optimization model successfully reproduced the ankle-to-hip strategy transition observed in human postural responses. With increasing perturbation magnitude, the model demonstrated a pattern of limited ankle torque coupled with increased hip joint kinematics, closely aligning with observed human postural adaptations. These results suggest that the adaptive nature of human postural strategy transitions can be understood within an optimization framework incorporating biomechanical constraints. Additionally, this study supports the use of RL models, capable of implementing nonlinear optimization, as a valuable tool for comprehensively analyzing diverse adaptive characteristics in human movement.
A novel approach to compute discrete nonlinear single unit activity features
Authors: Zakharov Nikita , Belova Elena , Gamaleya Anna , Tomskiy Alexey , Sedov Alexey
Published: October 2024

Purpose
Nonlinear single unit activity (SUA) characteristics are the useful measures to reveal the in-formation processing and transfer features associated with Parkinson’s disease (PD) in the basal ganglia. Most of the state-of-the-art approaches to compute such parameters in continuous and discrete forms are strongly dependent on SUA recording length, noise level and input parameters. Due to the specificity of SUA data collection (mainly short recordings with relatively low signal-to-noise ratio) new techniques to evaluate neuronal nonlinear properties are needed.
Methods
We have developed an encoding technique based on a mean interspike interval (ISI) value to calculate spike train discrete nonlinear features. The approach to compute mutual information (MI) of isolated neurons with its unstructured activity was also proposed.
Results
The proposed technique of SUA nonlinear features evaluation slightly depends on spike train length, independent on input parameters and has low correlations with other SUA characteristics (firing rate, coefficient of ISI variance and asymmetry index). The derived entropy measure in the subthalamic nucleus has significant positive correlation with PD severity. Also, the developed mean ISI based measures reflect the more complex nature of oscillatory activity in the basal ganglia, than it was thought previously. Moreover, MI, unlike entropy, takes into account the position of the spike train elements, which allows us to investigate the amount of information retained after the occurrence of temporary failures.
Conclusion
The developed approach may be useful in describing nonlinear features of basal ganglia ac-tivity contributing to PD pathophysiology probably associated with impaired information transfer in movement disorders.
Exploring the Impacts of Help-seekers’ Knowledge, Belief, and Attitude on the Choice of Treatment for Substance Use Disorder
Authors: Nwaoru Chiamaka R , Iloma David O. , Ijere Ignatius N
Published: October 2024

Background: Recently, Abia State, like other states in Nigeria, has been experiencinga growing number of deaths due to substance use, leading to substance use disorders and comorbidities. Family members and relatives usually seek treatment for those who, in some cases, do not have insight. However, their knowledge of how the substance affects, erroneous beliefs, and attitudes can reasonably impact theirchoice of treatment when a family member is affected.
Aim: Thisstudy investigated people's knowledge, beliefs, and attitudes and how they affect their treatment choices.
Method: A purposive sampling technique was employed to recruit 1,200 participants from a cross-sectional survey of three LGAs in Abia State. The35-item Knowledge, Beliefs, and Attitude Toward Treatment Questionnaire (KBATQ) was utilized to measure the study variables. Three hypotheses were advanced, and the data were analyzedvia IBM SPSS-23.
Results: Descriptive results revealeda high proportion of patients with poor knowledge of drug use disorders (up to 53.7%) as an issue that requiresmedical and therapeutic intervention. Multiple regression analyses indicated that having good knowledge, belief, and attitude toward drug use as a disorder predicted a high level of evidence-based treatment options for relatives of drug users (F (3, 1199) = 177.23, p<0.05). The study also revealed poor availability of rehabilitation centers.
Conclusion: In line with these findings, we concluded that the Abia State government should, as a matter of urgency, intensify drug use sensitization programs andlook into building more rehabilitation centers and that professionals, such as psychiatrists, clinical psychologists, and those who have completed universal treatment curriculum (UTC) courses,should be employed to provide evidence-based treatments for substance users. Relevant policies and interventions should target underlying socioculturalissues, such as stigma, lack of awareness, and cultural acceptance of substance use, to ensure greater effectiveness of interventions. Healthcare professionals, policymakers, and researchers have a crucial role in implementing these recommendations and improving the situation in Abia State.
Diagnóstico de la problemática de los pasivos ambientales mineros (PAM) producto de la extracción de materiales de construcción en el municipio de Mondoñedo, departamento de Cundinamarca.
Authors: Cespedes Guevara Nelly Yolanda
Published: October 2024

Los pasivos ambientales mineros (PAMs) hacen referencia a zonas en las que se necesita implementar una restauración, mitigación o compensación a un daño producido por actividades mineras inactivas. Para [8] “la minería abandonada tiene un amplio rango de impactos ambientales y socioeconómicos” ; siendo los impactos ambientales más frecuentes los paisajes físicamente alterados, pilas de desechos, subsidencia, pérdida de fauna y flora. El impacto socioeconómico puede ser evidenciado por la pérdida de suelo con potencial productivo, alterando un factor importante para el sustento de las poblaciones aledañas a la zona abandonada. Según [7], los pasivos ambientales mineros (PAMs), son todas aquellas afectaciones al medio ambiente que no han sido, o no fueron compensadas por los titulares mineros. Actualmente se busca remediar casos en los que las empresas mineras en ninguna de sus etapas realizaron un debido proceso de remediación, siendo esto una gran problemática, ya que nos da una visión de que, en Colombia antes de las leyes vigentes que toman como principal foco de atención la gestión ambiental.
Los instrumentos de gestión ambiental: pasivos sociales desde Peñol-Guatapé hasta Hidroituango
Authors: Araujo medina Luis carlos , Diaz Muegue Luis Carlos , Gallo Carvajal Diego Humberto
Published: October 2024

Los instrumentos de la gestión ambiental buscan ser las herramientas que calculan, regulan y dimensionan las consecuencias de las acciones y actividades que han sido puestas en marcha por el raciocinio instrumental humano. Es en este sentido que los proyectos de generación de energía demandan la puesta en común de varios saberes en medio de la interacción hombre-naturaleza, por lo cual y como parte de la propuesta de análisis, se toman dos proyectos energéticos: uno de ellos desarrollado hace poco más de 40 años y otro que se encuentra en su etapa de construcción y próximo a entrar en operación. Estos proyectos con notables diferencias temporales, espaciales y contextuales pero que, en la revisión de las afectaciones al entorno y las poblaciones, presentan un patrón en los impactos generados como en la forma en que fueron y son gestionados. Se muestra así, como esta forma de análisis e inventario de las consecuencias e impactos de los proyectos revisados, aporta elementos de análisis que robustecen las herramientas en la gestión ambiental en un sentido amplio y vinculante con elementos prospectivos.
Editorial
Authors:   UNSW Sydney, Jung Jae Yup
Published: October 2024

Welcome to the second issue of the Australasian Journal of Gifted Education for 2024. First of all, I am delighted to announce that the journal is continuing to rise in international standing and influence. Specifically, in the recently released international journal rankings, the Australasian Journal of Gifted Education achieved a: • SCImago Journal Rank (SJR) of 0.393, which is its highest ever, and places it in the second quartile of international journals in Education for the very first time. According to the SJR quartile, the journal is now the equal number three ranked international journal in gifted education (only behind Gifted Child Quarterly and Roeper Review). • Source Normalised Impact Per Paper (SNIP) of 1.282 for the journal is the highest ever, and places it as the outright fourth ranked international journal in gifted education. • The CiteScore of the journal is the highest ever at 2.90, which represents a 32% increase from the CiteScore for 2022. This is an outstanding achievement for the journal, considering its small, regional base. I wish to take this opportunity to thank the many contributors to the journal, the editorial team, and of course, the readers of the journal, for making all this possible.
Exploring Citation Patterns of Australian Research into Teachers of Gifted Students through a Focused Study of Articles Published in the Australasian Journal of Gifted Education 1992- 2024
Authors:   Federation University, Plunkett Margaret
Published: October 2024

This document analysis sought to examine the nature and scope of articles relating to teaching and giftedness published in Australia’s only gifted education journal – the Australasian Journal of Gifted Education (AJGE) from 1992 to 2024. Utilising the Publish or Perish software program to identify a corpus of related literature published in the AJGE since its inception, 43 articles were chosen as fitting the search criteria. For each article, basic descriptors are provided including the frequency of citing other research from within the AJGE. Previous research has identified limitations in Australian gifted education research but also acknowledged the small and relatively young field’s promising achievement of a level of recognition through a developing citation profile (Jolly et al., 2024). Yet this could be enhanced through a more dedicated commitment on the part of Australian researchers to cite relevant Australian research wherever possible, to ensure the continued progression of our citation profile. This study provides insight into citing patterns by AJGE authors in one topic area, in the hope that it will encourage future contributors to more frequently examine and cite local research in the field.
The Aristotelian Conception of δύναμις in Arendt’s Understanding of Power
Authors:   Russian Christian Academy for the Humanities named after Fyodor Dostoevsky, Iurina Ekaterina S.
Published: October 2024

Hannah Arendt, one of the most significant political and philosophical intellectuals of the 20th century, frequently brought up the issue of power. In The Human Condition, to distinguish power from force, strength, and, particularly, violence, she pointed out that the word ‘power’ had been derived from the Aristotelian conception of δύναμις. Since Arendt had written about power as the capacity to act together in the political realm, her understanding of the term δύναμις was credited to Aristotle. In order to make the distinction between power and its extremity, that is, violence, in Arendt’s theory more comprehendible, it is crucial to examine the Aristotelian conception of the term δύναμις and its original definitions, which are mostly found in Metaphysics. This paper aims to provide a philosophical analysis of δύναμις in Aristotle to clarify Arendt’s notion of power as well as her theory of action. In the first part of the article, the author discusses the word δύναμις which had a variety of meanings in antiquity including power, potentiality, potency, capacity, possibility, and force. Unlike common meanings, Aristotle used the word δύναμις in its relation to the term ἐνέργεια, which were usually translated as ‘potentiality’ and ‘actuality’. Aristotle defined δύναμις as the principle of change, that is, the power or capacity to act and be affected, which reveals itself when it achieves its fulfilment, or ἐνέργεια. In the second part, the author demonstrates that Arendt’s concept of power is based on the Aristotelian δύναμις as the power to act together, which cannot be stored up and exists only in its actualization. The author concludes by saying that power in the Aristotelian sense cannot be substituted for violence but instead manifests itself in the ability to be a political human being.
Automatic generation of physics items with Large Language Models (LLMs)
Authors: Omopekunola Moses Oluoke , Kardanova Elena Yu
Published: October 2024

High-quality items are essential for producing reliable and valid assessments, offering valuable insights for decision-making processes. As the demand for items with strong psychometric properties increases for both summative and formative assessments, automatic item generation (AIG) has gained prominence. Research highlights the potential of large language models (LLMs) in the AIG process, noting the positive impact of generative AI tools like ChatGPT on educational assessments, recognized for their ability to generate various item types across different languages and subjects. This study fills a research gap by exploring how AI-generated items in secondary/high school physics aligned with educational taxonomy. It utilizes Bloom's taxonomy, a well-known framework for designing and categorizing assessment items across various cognitive levels, from low to high. It focuses on a preliminary assessment of LLMs ability to generate physics items that match the Bloom’s taxonomy application level. Two leading LLMs, ChatGPT (GPT-4) and Gemini, were chosen for their strong performance in creating high-quality educational content. The research utilized various prompts to generate items at different cognitive levels based on Bloom's taxonomy. These items were assessed using multiple criteria: clarity, accuracy, absence of misleading content, appropriate complexity, correct language use, alignment with the intended level of Bloom's taxonomy, solvability, and assurance of a single correct answer. The findings indicated that both ChatGPT and Gemini were skilled at generating physics assessment items, though their effectiveness varied based on the prompting methods used. Instructional prompts, particularly, resulted in excellent outputs from both models, producing items that were clear, precise, and consistently aligned with the Application level of Bloom's taxonomy.
Manufacturing natural soap-base (Multiclean) with the addition of wuluh starfruit extraction (Averrhoa)
Authors:   Department of Chemical Engineering, Universitas Bosowa, Makassar City, Indonesia, Hamsina Hamsina , Safira Ifa ,   Department of Natural Science Education, Universitas Bosowa, Makassar City, Indonesia, Ekowatiningsih Dyah ,   Department of Nursing, Makassar Ministry of Health Polytechnic, Makassar City, Indonesia, Hasani Ruslan ,   Department of Nursing, Makassar Ministry of Health Polytechnic, Makassar City, Indonesia, Tang M. ,   Department of Chemical Engineering, Universitas Bosowa, Makassar City, Indonesia, Hermawati Hermawati ,   Department of Chemical Engineering, Universitas Bosowa, Makassar City, Indonesia, Granita Granita ,   Department of Chemical Engineering, Universitas Bosowa, Makassar City, Indonesia
Published: October 2024

Starfruit extract is used as a base for making natural soap that is more environmentally friendly and beneficial for health. The aim of this study is to identify the optimal conditions for adding starfruit extract to natural soap production, which involves citric acid and surfactant components. The method involves maceration and extraction of starfruit to obtain citric acid by immersing it in 80% ethanol. The soap is produced using a hot process at temperatures between 70-80°C with three formulas: F1 (200:200:10), F2 (225:175:15), and F3 (250:150:20), representing different ratios of virgin coconut oil (VCO), olive oil, and starfruit extract, respectively. Potassium hydroxide (KOH) is used as an alkali at a concentration of 30%. After the soap is made, MES (a plant-based surfactant), sodium citrate (Na3C6H5O7) as a preservative, and sodium bicarbonate (NaHCO3) as a cleanser are added. Testing of the three soap formulas showed they all meet Indonesian National Standards (SNI). Among 20 respondents, F1 was rated the highest in terms of color, scent, and softness. It had 83% foam stability, 0.85% moisture content, a pH of 8, and 0.001% free alkali content. These results suggest that consumer preference is influenced by the starfruit extract content.
Methods for assessing the innovative potential of a region: a comparative approach
Authors: Losev E. A.
Published: October 2024

Relevance. The development of the innovative potential of a region has important theoretical, methodological and practical significance. Of particular importance is the methodology for assessing the innovative potential of a region. To form the author's position on this issue, it is necessary to apply a comparative approach to the analysis of existing approaches to assessing the innovative potential of a region. This circumstance allowed us to choose and prove the relevance of the topic of the conducted scientific research.

The purpose of the study is to apply a comparative approach to the analysis of methods for assessing the innovative potential of a region.

The objectives of the study are formulated in accordance with the stated goal and involve the study of various well-known methodological approaches to assessing the innovative potential of a region, such as the European Innovation Scoreboard, Regional Innovation Scoreboard, Innovation Index, Rating of Innovative Development of Subjects of the Russian Federation of the Institute for Statistical Studies and Economics of Knowledge of the National Research University Higher School of Economics.

Methodology. The research methodology is based on a comparative approach to the analysis of methods for assessing the innovative potential of a region. Comparative analysis, statistical research, and the cause-and-effect approach form the basis of the study.

Results. The results of the study include a comparative analysis of various approaches to the analysis of methods for assessing the innovative potential of a region.

Conclusions. Based on the obtained research results, the author's approach to constructing a methodology for assessing the innovative potential of a region will be proposed in the future, taking into account the elements of the studied methods. This study is the initial stage for substantiating the author's vision of assessing the innovative potential of a region.
The regional features of digitalization in public administration: experience of the Orel region
Authors: Samorodova E. M. , Samorodova E. M.
Published: October 2024

Relevance. Russian regions are characterized by varying degrees of readiness for the introduction of digital technologies into the management system, this process often takes place formally and does not imply a significant change in the format of interaction between the population and business, on the one hand, and regional executive authorities, on the other. The study of the specifics of digitalization of public administration will allow to identify "bottlenecks" for improving measures to support digital transformation at the level of the subject of the Russian Federation, to identify and replicate successful experience.

The purpose of the article is predetermined by its topic and is to determine the regional features of the digitalization of public administration in the Orel region.

Objectives. To achieve this goal, the theoretical, methodological, organizational and regulatory foundations of digitalization of public administration are considered, a comparative analysis of key indicators of digitalization in this area is carried out, the opportunities and threats of digitalization are determined, taking into account the specifics of the socio-economic development of the region under study.

Methodology. The materials for the study were official statistics presented on the official websites of the Federal State Statistics Service of Russia, compiled by constituent entities of the Russian Federation in the “Information Society” section. The main research methods are statistical analysis of data series, comparative analysis, SWOT analysis.

Results. Based on the results of the study, it was revealed that the basic conditions for the digital transformation of management in the Oryol region have been formed: relevant regional strategies and programs have been developed and are being implemented, benchmarks for their implementation have been established, the system of authorities is functioning and the infrastructure necessary for successful digitalization is being developed. At the same time, there is no list of specific measures necessary for the integration of state regional information systems into federal super services, measures for personnel and financial support for digitalization processes, increasing the level of digital literacy of the population, and intensifying outreach work among the population. Solving these problems will improve the efficiency of the digital transformation of public administration in the Orel region.

Conclusions. Regional specifics determine the effectiveness of the digital transformation of public administration in the constituent entities of the Russian Federation, and therefore regional programs should not only repeat federal initiatives, but also adapt them taking into account the territorial characteristics of socio-economic development.
Synchronous and asynchronous tele-exercise for older adults: study protocol for a randomized clinical trial
Authors: Fernanda Nelli Gomes Giuiani  , Natália Ramalho Jacobino  , Karla Helena Coelho Vilaça e Silva
Published: October 2024

Objective: Multicomponent physical training, carried out via tele-exercise, can contribute to a healthier lifestyle in the elderly. The objective is to present the intervention protocol of the “Idoso Ativo” (Active Older Adult) program via tele-exercise, synchronously and asynchronously. Method: This is a randomized clinical trial with two groups performing tele-exercise. Participant recruitment will be done via digital platforms, social media pages and printed leaflets distributed in the different regions of Distrito Federal. Both groups will perform exercises three times a week, lasting 50 min, and the intervention period will be 12 weeks. Discussion: The hypothesis is that the multicomponent exercise program offered online will provide improvements in muscular strength, balance and mobility in both groups. A higher adherence rate is expected in relation to the asynchronous group, and it is believed that the positive effects on physical health, minimizing the negative outcomes caused by inactivity, are present in participants in both groups.
Stuart Stress Adaptation and Nola Pender's Model on Mental Nursing Care of Patients Schizophrenia: Case Study
Authors: Hikmat Rohman , Yosep Iyus , Widianti Efri , Suryani Suryani , Sriati Aat , Susanti Icih
Published: October 2024

To describe the application of the Stuart Stress Adaptation and Nola Pender Models in mental nursing care for a patient with schizophrenia and risk of violent behavior. This research method used case studies. The sample is one patient with schizophrenia. Data collection is done through direct observation, interviews, and patient medical records. The results showed that the client showed a major nursing problem in the form of risk of violent behavior. Predisposing factors included passive childhood experiences and socio-cultural issues, while precipitation included feeling disrespected by the husband's family. Nursing interventions provided to the patient included logotherapy, forgiveness therapy, and psychoeducation to the family. Family psychoeducation forms a supportive system in the client's recovery process. The results of this study indicate that there is a reduction in symptoms of violent behavior in schizophrenia patients. The importance of integrating the Stuart Stress Adaptation and Nola Pender Model in the psychiatric nursing care of patients with paranoid schizophrenia.