bluuebunny/crossref_metadata_2025 huggingface dataset:
A Direct Negative Feedback Loop of miR-4721/FOXA1/Nanog Promotes Nasopharyngeal Cell Stem Cell Enrichment and Metastasis 
Authors: Zhao Mengyang , Tang Zibo , Wang Yijun , Ding Jiaojiao , Guo Ying , Gao Tianhui
Published: March 2021

Objective: The recurrence and metastasis of nasopharyngeal cancer (NPC) may be mainly attributed to the persistence of cancer stem cells (CSCs); however, the linkage mechanism has yet to be fully elucidated. Methods: The levels of miR-4721, FOXA1, and Nanog expression in NPC were detected by in situ hybridization and immunohistochemistry. In vivo and in vitro metastasis assays confirmed miR-4721 promotes cell migration and invasion. Tumor spheroid formation assay, side population (SP) assay, and ALDEFLUOR assay verified miR-4721 regulates cancer stem cell-like properties. Luciferase reporter assay showed that miR-4721 directly regulates FOXA1 and FOXA1 effects the promoter activity of miR-4721 and Nanog. Chromatin immunoprecipitation (ChIP) analysis and electrophoresis mobility shift assay (EMSA) revealed that FOXA1 combined the promoter region of human miR-4721 and Nanog and the possible mechanism was also analyzed.Results: In this study, a new mechanism of NPC tumorigenesis related to miR-4721 was verified. We found that miR-4721, FOXA1 and Nanog control their expressions through a negative feedback loop and then activate the downstream regulator of stem cell signaling to promote the enrichment and metastasis of NPC stem cells. Conclusion: These ﬁndings elucidate that the feedback loop of miR-4721/FOXA1/Nanog can regulate stemness and metastasis in NPC and may provide an experimental theoretical basis for metastasis and treatment resistance in NPC.
No association between proton pump inhibitor use and dementia risk: data mining of US Food and Drug Administration adverse event reporting system
Authors: Wu Bin , Hu Qiaozhi , Tian Fangyuan , Wu Fengbo , Li Yuwen , Xu Ting
Published: March 2021

Proton pump inhibitors (PPIs) were widely used around the world. Studies suggested conflicting results between PPIs treatment and the risk of dementia. This study examined the association between six PPIs and dementia risk by mining the US FDA Adverse Event Reporting System (FAERS) database from 2004 to 2019. We employed reporting odds ratio (ROR) and proportional reporting ratio (PRR) to detect the signals of dementia relevant to PPIs. We also analyzed characteristics of PPI reports, compared dementia events between short- and long- duration PPIs treatment. Finally, we identified 2104 dementia cases with PPIs treatment. We did not detect significant signals between PPIs and dementia, ROR = 0.99, 95%CI 0.94–1.03, PRR = 0.99, 95%CI 0.95–1.03, even in gastroesophageal reflux disease cases ROR = 0.65, 95%CI 0.58–0.73, PRR = 0.67, 95%CI 0.60–0.74. No significant differences of dementia events were detected between short- and long- duration groups, the OR (95%CI) of the 6 months, 1 year, 3 years and 5 years comparison were 0.85 (0.68–1.06), 0.92 (0.71–1.18), 0.81 (0.57–1.15) and 0.79 (0.52–1.22), respectively. Based on the current FAERS data mining, we discovered no association between PPIs use and the risk of dementia.
Real Exchange Rate and Services Export Diversification
Authors: Gnangnon Sèna Kimm
Published: March 2021

The relationship between real exchange rate and services export diversification is at the heart of this study. The analysis is performed using a sample of 125 countries over the period 1985-2014, and the two-step system Generalized Methods of Moments (GMM) approach. It shows that for both high income countries and developing countries, real exchange rate depreciations promote services export diversification and increase the total number of services export lines. These findings highlight the strong importance of real exchange policies in promoting services export diversification in high-income countries and developing countries alike.
Sarcasm Detection Engine for Twitter Sentiment Analysis using Textual and Emoji Feature
Authors: Wiguna Bagus Satria , Hudiyanti Cinthia Vairra , Alqis Rausanfita Alqis , Arifin Agus Zainal
Published: March 2021

Twitter is a social media platform that is used to express sentiments about events, topics, individuals, and groups. Sentiments in Tweets can be classified as positive or negative expressions. However, in sentiment, there is an expression that is actually the opposite of what is mean to be, and this is called sarcasm. The existence of sarcasm in a Tweet is difficult to detect automatically by a system even by humans. In this research, we propose a weighting scheme based on inconsistency between sentimen of tweet contain in Indonesian and the usage of emoji. With the weighting scheme for the detection of sarcasm, it can be used to find out a sentiment about a event, topic, individual, group, or product's review. The proposed method is by calculating the distance between the textual feature polarity score obtained from the Convolutional Neural Network and the emoji polarity score in a Tweet. This method is used to find the boundary value between Tweets that contain sarcasm or not. The experimental results of the model developed, obtained f1-score 87.5%, precision 90.5% and recall 84.8%. By using the textual features and emoji models, it can detect sarcasm in a Tweet.
Automatic Image Self-Enhancement for Multi-Scale Spectral on Low Resolution Video
Authors: Halim Arwin , Winardi Sunaryo , Halim Erlina
Published: March 2021

MSR technique is a process used to reduce the search area in an image. MSR relies heavily on image salience from image capture devices. The purpose of this study is to improve the detection of people's objects on video by increasing the quality of the image frames on video and MSR. This research uses artificial video taken in a room installed by CCTV. Object detection is evaluated using precision, recall, and fscore values. The results showed an increase in the quality of the performance of object detection that was properly detected as a person. The average detection performance is indicated by an fscore of 14.47%. Increasing the quantity of detection of objects of people reached 168.8% compared to the detection of only using MSR
A Bonferroni Mean Based Fuzzy K Nearest Centroid Neighbor Classifier
Authors: Widyadhana Arya , Putra Cornelius Bagus Purnama , Indraswari Rarasmaya , Arifin Agus Zainal
Published: March 2021

K-nearest neighbor (KNN) is an effective nonparametric classifier that determines the neighbors of a point based only on distance proximity. The classification performance of KNN is disadvantaged by the presence of outliers in small sample size datasets and its performance deteriorates on datasets with class imbalance. We propose a local Bonferroni Mean based Fuzzy K-Nearest Centroid Neighbor (BM-FKNCN) classifier that assigns class label of a query sample dependent on the nearest local centroid mean vector to better represent the underlying statistic of the dataset. The proposed classifier is robust towards outliers because the Nearest Centroid Neighborhood (NCN) concept also considers spatial distribution and symmetrical placement of the neighbors. Also, the proposed classifier can overcome class domination of its neighbors in datasets with class imbalance because it averages all the centroid vectors from each class to adequately interpret the distribution of the classes. The BM-FKNCN classifier is tested on datasets from the Knowledge Extraction based on Evolutionary Learning (KEEL) repository and benchmarked with classification results from the KNN, Fuzzy-KNN (FKNN), BM-FKNN and FKNCN classifiers. The experimental results show that the BM-FKNCN achieves the highest overall average classification accuracy of 89.86% compared to the other four classifiers.
Revisión taxonómica del género Sapium Jacq. (Euphorbiaceae) en Honduras
Authors: Díaz Rina Fabiola
Published: March 2021

Se presenta una revisión taxonómica del género Sapium Jacq. (Euphorbiaceae) en Honduras basada en caracteres morfológicos obtenidos a través de material de herbario, así como una clave dicotómica para la identificación de las especies del país. Se registran tres especies que crecen de forma silvestre: Sapium glandulosum, S. laurifolium y S. macrocarpum (esta última presenta el mayor rango de distribución). Este género tiene una amplia historia de cambios nomenclaturales y de circunscripción de especies por sus características morfoanatómicas, por lo que en el futuro será necesaria una revisión dentro de un marco filogenético.
Lymphocyte Proliferation and Nitric Oxide-Producing Activities of Lupeol Isolated From Red Dragon Fruit (Hylocereus polyrhizus) Extract
Authors: Wahdaningsih Sri , Wahyuono Subagus , Riyanto Sugeng , Murwanti Retno
Published: March 2021

Background: Hylocereus polyrhizus has activities as antimicrobial agent, anti-hypercholesterolemia, anti-diabetic (diabetes mellitus), cardiovascular risk reduction, health supplement, and melanoma cell suppression. The extracts from the peels of H. polyrhizus were able to increase phagocytic ability, cell numbers and leukocytes and to influence relative spleen weights in the formation of body immune system in male rats. The fruit peels contained phenolics, flavonoids, carotenoids, and anthocyanins. This study investigated the active compounds of H. polyrhizus peels, which are able to increase immune system of human body.Materials and method: In vitro assay was applied to examine the active compounds, identified as lupeol, obtained from isolated extract of red dragon fruit for their lymphocyte proliferation and nitric oxide (NO)-producing activities. Lymphocyte proliferation assay was performed with 3-4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) method. The cell control was lymphocyte cell suspension in RPMI medium added with phytohaemaglutinine (PHA). The NO measurement was conducted with nitric solvent and Greiss reagent.Results: The ANOVA analysis of the average optical density (OD) of lymphocyte proliferation showed that the addition of isolated lupeol at the concentrations of 6.25, 12.5, 25, 50 and 100 µg/mL were able to improve lymphocyte proliferation and activate the NO production in the rats with treatment of positive control. Conclusion: Isolated lupeol at concentrations of 6.25, 12.5, 25, 50 and 100 µg/mL revealed significant difference with medium control and cell control. It was able to increase effects on lymphocyte proliferation and NO production. Therefore, the lupeol which was isolated might have high potential to be an immunostimulant.Keywords: Hylocereus polyrhizus, lupeol, lymphocyte proliferation, nitric oxide production
Elevated Serum Reactive Oxygen Species Level Predicts Early Abortion
Authors: Serudji Joserizal , Irawati Nuzulia , Mose Johanes Cornelius , Ali Hirowati , Yusrawati Yusrawati
Published: March 2021

Background: Impaired trophoblast invasion is associated with early abortion. The calorie needed for the trophoblast cell (TC) invasion is mainly met by adenosine triphosphate (ATP) produced in the mitochondria. Reactive oxygen species (ROS), byproduct of ATP synthesis, plays an important role in cellular physiology, but a high level of ROS may result in deoxyribonucleic acid (DNA) damage or cell dysfunction, thereby impaired TC invasion leading to early abortion. The study aims to determine elevated serum ROS level to predicts early abortion.Materials and method: This was an observational study with a cross-sectional design. Fifty subjects with gestational age less than 12 weeks, consist of 25 early abortions and 25 normal pregnancies subjects, were included in this study. Clinical examination and diagnosis are carried out in 2 Hospitals and 5 Public Health Centers in Padang. Examination of ROS levels was carried out by enzyme-linked immunosorbent assay (ELISA) in the Biomedical Laboratory, Faculty of Medicine, Universitas Andalas. The Mann-Whitney test was used to analyze the difference of serum ROS levels, with a significance level of 0.05.Results: The subjects of the two study groups were equivalent in terms of age, gestational age, and gravidity (p=0.051, p=0.453, and p=1.000). The median ROS levels were found to be 1.36 (1.02-26.30) ng/mL in the early abortion and 1.20 (0.43-2.75) ng/mL in the normal pregnancy (p=0.003).Conclusion: There is a significant difference between ROS levels in early abortion and normal pregnancy.Keywords: ROS, early abortion, normal pregnancy
Predicted SARS-CoV-2 miRNAs Associated with Epigenetic Viral Pathogenesis and the Detection of New Possible Drugs for Covid-19
Authors: Çetin Zafer , Bayrak Tuncay , Oğul Hasan , Saygılı Eyüp İlker , Akkol Esra Küpeli
Published: March 2021

Objective:

The outbreak of COVID-19 caused by SARS-CoV-2 has promptly spread
worldwide. This study aimed to predict mature miRNA sequences in the SARS-CoV-2 genome,
their effects on protein-protein interactions in the affected cells, and gene-drug relationships to detect
possible drug candidates.

Methods:

Viral hairpin structure prediction, classification of hairpins, mutational examination of
precursor miRNA candidate sequences, Minimum Free Energy (MFE) and regional entropy analysis,
mature miRNA sequences, target gene prediction, gene ontology enrichment, and Protein-Protein
Interaction (PPI) analysis, and gene-drug interactions were performed.

Results:

A total of 62 candidate hairpins were detected by VMir analysis. Three hairpin structures
were classified as true precursor miRNAs by miRBoost. Five different mutations were detected in
precursor miRNA sequences in 100 SARS-CoV-2 viral genomes. Mutations slightly elevated MFE
values and entropy in precursor miRNAs. Gene ontology terms associated with fibrotic pathways
and immune system were found to be enriched in PANTHER, KEGG and Wiki pathway analysis.
PPI analysis showed a network between 60 genes. CytoHubba analysis showed SMAD1 as a hub
gene in the network. The targets of the predicted miRNAs, FAM214A, PPM1E, NUFIP2 and
FAT4, were downregulated in SARS-CoV-2 infected A549 cells.

Conclusion:

miRNAs in the SARS-CoV-2 virus genome may contribute to the emergence of the
Covid-19 infection by activating pathways associated with fibrosis in the cells infected by the virus
and modulating the innate immune system. The hub protein between these pathways may be the
SMAD1, which has an effective role in TGF signal transduction.
An in silico Approach Towards Crop Improvement by ACC Synthase Inhibition Declining Ethylene Production
Authors: Ali Jasarat , Mishra Rupesh K. , Gupta Chhedi L. , Sharma Dinesh C. , Bajpai Preeti , Pathak Neelam
Published: March 2021

Introduction:

The increased level of ethylene inhibits root elongation and
causes physiological damage, thereby reduces ethylene level imparts a positive support
against various biotic and abiotic stresses viz. phytopathogens, extreme temperatures,
hyper salinity, flooding, drought, metal/organic contaminants and insect
predation. The metabolic pathways showed the involvement of ACC synthase inhibition
for ethylene suppression in plants.

Objective:

The primary objective of this study focused towards the use of In-silico
approach to assess the inhibitory effect of S-adenosyl methionine (SAM) analogue
on ACC synthase activity.

Methods:

The 3D structure of ACC synthase of Pisum sativum was constructed using modeler 9v11
software. The reliability of developed model was evaluated by PROCHECK, ERRAT and ProSA web
servers. Furthermore the molecular interactions between substrate SAM and inhibitors were performed.

Result:

The docking study demonstrated that the binding energy of the substrate SAM is -5.37
Kcal/mol. The SAM analogue (Inhibitors) considered in this study were 3-dzSAHC, SAHC, sinefungin,
SIBA, 7-dz-SIBA, 1-dz-SIBA,3-dz-SIBA and S-n-Butyladenosine. Among these analogues, 7-dz-SIBA
was found to be most effective on ACC synthase as inhibitor due to lowest binding energy (-
5.51Kcal/mol) and strong Ki value (91.74M). The LYS276 amino acid residue of ACC synthase was
observed in the interaction with both substrates SAM and 7-dz-SIBA (S-isobutyl-7-deazaadenosine)
demonstrates as most crucial catalytic residue for molecular interaction.

Conclusion:

This study successfully screened most potent inhibitor for ACC synthase which have
indicated the compounds 7-dz- SIBA as effective inhibitor with lowest binding energy, better hydrogen
bond interaction and strong inhibition constant compared to others compounds studied. Thus 7-dz-SIBA
can be projected to use as a growth enhancer for overall crop improvement. It may help in plant growth
promotion, prevents the plants from various environmental stress and phytopathogenic infections etc.
Photothermal Therapy: A New Approach to Eradicate Cancer
Authors: Dash Somya Ranjan , Kundu Chanakya Nath
Published: March 2021

:

The use of hyperthermal temperature to treat solid cancers is known as oncological thermal
ablation. Thermal ablation is studied as a therapeutic strategy for most cancers and can be used
in the control of local and metastatic diseases in addition to traditional anticancer therapies. PTT
(photothermal therapy) is a minimally invasive therapeutic approach with a promising diagnostic and
cancer prevention potential. The excitation of photosensitizer materials like inorganic and organic
nanomaterials with NIR (near-infrared radiation) showed significantly better results than the traditional
mode of cancer treatment. The penetration depth of NIR is significantly higher as compared to
the U.V. (ultraviolet) and visible light. Photo-excitation of the nanomaterials with NIR efficiently
converts light energy into heat energy and eventually enables the cancer cells to die due to heat
shock. The addition of a multimodal approach to the treatment and the prevention of cancer cells
thermo-resistant properties in localized and distal tumors involves the combination of photothermal
agents and chemotherapy. Cancer cell hyperthermic activation prevents DNA repair, cell survival
signaling and eventually induces apoptosis. Simultaneously, the release of antigenic peptides from
the dead cancer cells activates the immune cells which kill the localized and metastatic cancer cells,
hence enabling long-term immunological memory retention. The present review summarizes PTT's
functional properties, NIR penetration ability, DNA repair, cellular signaling, and immune system
modulation effect of hyperthermia. The benefits of using different types of nanomaterials in PTT
applications are further explored. In addition, the problems associated with the use of nanomaterials
in PTT applications are also addressed in this article.
Economic Fluctuations: The Aftermath of COVID 19 Pandemic
Authors: Adithya Saishiv , Girigoswami Koyeli
Published: March 2021

:

The COVID-19 pandemic has necessitated focusing on the economic stressors for the
welfare of the population worldwide. This pandemic, which has affected individuals globally since
January 2020, has caused barriers in the business involving different sectors. The primary sector,
i.e., agriculture and food supplies, and the secondary sectors like the manufacturing units, oil and
petrol sector, transport sector, travel and tourism as well as the finance industries, have all faced
the adverse effect of this pandemic and subsequent lockdown. The different restrictions implemented
by the government in most of the countries like quarantine, self-isolation, sealing of national
and international borders, a complete shutdown of transport and travel, etc., have disrupted the
equilibrium of demand and supply. As an aftermath of such misbalance, the economic conditions
in all the sectors have been negatively impacted. In this review, we shall discuss the impact of
COVID-19 on the economic condition of different sectors like agriculture, logistics, petroleumbased
fuels, commodity market, hospitality and tourism, pharmaceutical industry, and finance industry.
IMAGE-TEXT RELATION INTERPRETATION: TEACHERS’ VISUAL-VERBAL COMPETENCE IN TEACHING TEXTS
Authors: Fajriah Yustika Nur , Hamied Fuad Abdul , Gunawan Wawan
Published: March 2021

Multimodal literacy instruction is such a new shift of the literacy in which the construction of knowledge is led to be more socially and contextually bounded. Due to the urgency that teachers have to own multimodal competencies, this study aimed to investigate EFL teachers’ competence in interpreting visual-verbal relations to teach multimodal texts. To collect the data, an online test through the Google form platform was distributed. As many as 43 responses were collected from junior and senior high school teachers in one of the cities in Indonesia. A semi-structured interview was also conducted with six purposive participants. The data in this research were then analysed based on Royce’s criteria of image-text relation. The analysis found that the teachers only partially possessed multimodal competencies. It means that that they had used images to help them teach the texts but had insufficient knowledge on how to utilize the images as meaning-making sources. Then, based on the finding, it is suggested that the teachers should improve their competences in interpreting multimodal meanings in texts, so images are used not only for making learning materials interesting but also for making more meanings from the texts.
DOES ELEMENTARY SCHOOL TEACHER’S PERFORMANCE MATTER?
Authors: Afandi Muhamad , Wahyuningsih Sri , Mayasari Linda Ika
Published: March 2021

The performance of teachers in realizing holistic education can be observed from how the teachers prepare, implement, and evaluate the learning process or their pedagogic knowledge. This study aims to examine the teachers’ ability to plan, implement and evaluate to assess their performance in the elementary school learning process based on tenure and gender. This research is a quantitative study with direct observation, which was conducted on 162 elementary school teachers from 30 public elementary schools in Semarang, Indonesia. Data were collected using assessment sheets. The observer was the principal which belonged to the same school as the respondent. The data were then validated using Pearson's correlation based on group tenure and gender. The instrument was analyzed using structural equation modelling (SEM) and showed that the imposition of the confirmatory factor analysis (CFA) was achieved more than a critical value of .50 which meant that the construct was valid and reliable. The understanding on teachers’ performance was indicated by teachers’ activities in preparing their class. This study found that there was no significant correlation between teachers’ performance and teaching experience or that and gender.
THE EFFECT OF INSTRUCTIONAL, TRANSFORMATIONAL AND SPIRITUAL LEADERSHIP ON ELEMENTARY SCHOOL TEACHERS’ PERFORMANCE AND STUDENTS’ ACHIEVEMENTS
Authors: Nurabadi Ahmad , Irianto Jusuf , Bafadal Ibrahim , Juharyanto Juharyanto , Gunawan Imam , Adha Maulana Amirul
Published: March 2021

Persistence for achievement reflected from the willingness and determination of principal to implement quality leadership will facilitate the improvement of teachers’ performance, and the two will be the determinant factors for the students’ ultimate achievement. This study aims at analyzing empirical data on the effect of instructional, transformational and spiritual leadership as independent variables, with school quality as the dependent variable. In addition, the intervening variable is teachers’ performance. This study employed the quantitative approach in which samples of 181 teachers were re taken using the proportional random sampling technique. All data were then analysed using the SEM technique with the AMOS 24 application. The findings show that: (1) there is a direct effect of instructional leadership on teachers’ performance, transformational leadership on teachers’ performance, spiritual leadership on teachers’ performance, instructional leadership on students’ achievement, transformational leadership on students’ achievement, spiritual leadership on students’ achievement, and teachers’ performance on students’ achievement. In addition, (2) there is an indirect effect of instructional leadership on students’ achievement through teachers’ performance, transformational leadership on students’ achievement through teachers’ performance and spiritual leadership on students’ achievement through teachers’ performance.
LEVELS OF STUDENTS’ MATHEMATICS ANXIETIES AND THE IMPACTS ON ONLINE MATHEMATICS LEARNING
Authors: Lailiyah Siti , Hayat Sihhatul , Urifah Siti , Setyawati Maunah
Published: March 2021

It is widely assumed that anxieties tend to lead to low mathematics performance. The purpose of this study was to describe the levels of students’ mathematics anxieties and the impacts on mathematics learning achievement in online mathematics learning. The study was a quantitative survey. The research instrument was questionnaire consisting of four elements of physiological, cognitive, affective, and behavioral aspects. The subjects were 109 mathematics education students who were willing to be the research participants. The data were collected using mathematics anxiety questionnaires and documentation of students’ mathematics learning achievement. The data analyses used descriptive statistics and confirmatory factor analysis with structural equation modeling of the Lisrel program. The findings show that the levels of all aspects of students’ mathematics anxieties in online mathematics learning were at the moderate level. The anxiety aspects that affect students’ mathematics learning achievement in online mathematics learning were of the affective and cognitive categories, while the physiological and behavioral aspects do not affect mathematics learning achievement. A research implication is for the teacher to pay attention to the cognitive and affective aspects of the students’ mathematics anxieties.
Geosocial networking app use is correlated with increased high-risk sexual behaviors and prevalence of HIV among Chinese men who have sex with men university students: A mixed offline and online cross-sectional survey (Preprint)
Authors: Li Hang , Leuba Sequoia I , Tang Weiming , Gao Yangyang , Peng Erlei , Lu Tianyi , Li Shangcao , Wang Hongyi , Chu Zhenxing , Zhang Jing , Hu Qinghai , Huang Xiaojie , Jiang Yongjun , Geng Wenqing , Shang Hong , Xu Junjie
Published: March 2021

BACKGROUND

The HIV infection prevalence is increasing rapidly among Chinese men who have sex with men (MSM) university students, and there is limited research on the association of mobile geosocial networking (GSN) apps use and HIV-related high-risk sexual behaviour and HIV prevalence among MSM university students.

OBJECTIVE

To provide evidence for tailored HIV intervention programs we conducted this study to examine the association between use of GSN apps and HIV-related behaviors and HIV prevalence among Chinese MSM attending university.

METHODS

Chinese MSM university students were recruited using mixed recruitment methods from 2017 to 2019. Data on sociodemographic, sexual behaviours, use of GSN apps, and eligibility for pre-exposure prophylaxis (PrEP) was collected. Participants were tested for HIV and syphilis, and positive cases were confirmed by laboratory testing.

RESULTS

We recruited 771 MSM university students: 76.3% (n=588) online and 23.7% (n=183) offline. Among all participants, the HIV prevalence was 3.5% (n=27), and 67.4% (n=520) were eligible for PrEP. GSN app users (81.2%, n=626) vs. GSN app nonusers (18.8%, n=145) were more likely to have used recreational drugs, have multiple male sexual partners, have casual sex, and have been tested for HIV in the past six months (all P < 0.05). After adjusting for age, residence, education, and recruitment method, GSN app users had an increased odds of HIV infection compared to GSN app nonusers (aOR=8.1 [95% CI: 1.05, 62.33]).

CONCLUSIONS

MSM university students who used GSN apps more frequently engaged in HIV-related high-risk sexual behaviours and had a higher prevalence of HIV infection compared to GSN app nonusers. GSN app platforms can reach Chinese MSM university students and should be used to promote HIV testing and implement sexual behavioural risk reduction interventions or PrEP.
Validasi Metode Analisa Amonia pada Air Tanah Menggunakan Metode Spectrofotometri
Authors: Muryanto Muryanto
Published: March 2021

Amonia dilepas kedalam air oleh adanya penguraian organik dan juga sebagai buangan metabolik organisme perairan. Amonia (NH4) merupakan senyawa nitrogen, Pada bentuk cairan, amonia terdapat dalam 2 bentuk yaitu amonia bebas atau tidak terionisasi (NH3) dan dalam bentuk ion amonia (NH4+).Penelitian ini menggunakan spertrofotometer. Tujuan dari penelitian ini adalah mendapatkan metode yang valid untuk penetapan kadar ammonia . Validitas metode ditunjukkan melalui parameter selektivitas, linearitas, LLOD, LLOQ, presisi, dan akurasi (% recovery). Panjang gelombang yang digunakan yaitu 425 nm,. Lineritas kurva baku unsur amonia  r = 0,996 dan KV = 1.99. Nilai LOD dan LOQ yang dihasilkan parameter Amonia  adalah  0,0032 ppm dan 0,0107 ppm. % Recovery parameter Amonia sebesar 98.929%, Presisi yang ditunjukkan dengan nilai KV memenuhi persyaratan validasi. Dengan hasil tersebut, maka dapat disimpulkan bahwa metode analisis parameter ammonia pada air tanah di Kecamatan Gondokusuman, Yogyakarta memenuhi persyaratan validasi.
Insider Perspectives of Mate Selection in Modern Chinese Society
Authors: Lin Szu-Yu , B Miller Richard , Su Li Ping , Whiting Jason , Bean Roy , Hsieh Chih-Han , Li Tsui-Shan
Published: March 2021

With the increased exposure to Western cultures and the transition towards modernization, Chinese society has experienced substantial social change, which has influenced marital relationships. Although recent research has documented contemporary patterns of marital interaction, less is known about what Chinese adults consider to be an ideal marital partner. The values of contemporary Chinese adults about mate selection preferences were addressed by conducting six focus groups in Taipei, Taiwan. The focus groups included a total of 51 participants (male=25; female=26) and included separate groups for middle-aged married men, middle-aged married women, younger married men, younger married women, never-married young adult men, and never-married young adult women. The results from qualitative analysis indicated three major themes in an ideal partner: family-of-origin, which included similar family background and good relationship with in-laws, personal qualities, which included financially stability and being responsible, and relationship qualities, which included getting along, communicating well, mutual respect, and gender equality. These results indicate that contemporary Chinese adults value a combination of traditional Chinese (e.g., similar family background) and Western (e.g., good communication) values. Overall, the young Chinese participants showed greater incorporation of Western values than the older participants. These findings suggest that modern Chinese society is being increasingly influenced by individualistic Western values.
МЕДНЫE КАБЕЛИ СВЯЗИ ДОЛЖНЫ СЛУЖИТЬ ЕЩЕ ДОЛГО
Authors: Лиманский Г. , Попов Б.
Published: March 2021

Рассматриваются проблемы подготовки специалистов рабочих профессий по телекоммуникационным направлениям для строительства, монтажа и технической эксплуатации линейно-кабельных сооружений связи на основе кабелей связи с медными проводниками.
ЗАМЕТКИ ОБ (ИНЖЕКТОРАХ) POWER OVER ETHERNET. ЧАСТЬ 2
Authors: Терентьев Д.
Published: March 2021

Статья посвящена вопросам технологии Power over Ethernet – разработке инжекторов, их совместимости с другим оборудованием, проблемам эксплуатации. В течение многих лет периодически возникали проблемы, которые автору приходилось решать, и вопросы, которые требовали ответа. Некоторые из них коротко описаны в этих заметках, в заголовке которых слово "инжекторы" помещено в скобки, так как все описанное относится, в значительной степени, к технологии PoE в целом.
Design of a Fractional Order PID Controller for Electric Hydraulic Actuator
Authors: Dyah Atsari Erinna , Halim Abdul
Published: March 2021

Electric hydraulic actuators are more used especially in industries that demand high levels of accuracy. A common problem with this type of actuator is consistency in fluid flow control. PID controllers can accelerate the achievement of defined output values, eliminate offsets, and reduce maximum overshoots but result in considerable errors. Therefore, it is necessary to design controllers that can reduce errors significantly. In this research, a Fractional Order PID controller is developed to reduce maximum overshoots and steady state. Unlike conventional PID controllers that have three  parameters, in the Fractional Order PID controller, there are extra two parameters of the λ and μ. The   parameters were selected using the Ziegler Nichols method with a 1st order approach with a delay time. Meanwhile, the λ and μ parameters were selected the best value to make the system response better. The results of the design of the Fractional Order PID controller were evaluated using matlab simulation. The simulation results showed that the Fractional Order PID controller was able to reduce the steady state error response by 0.5 %, and the maximum overshoots by 17.4 %. From this result, it can be noted that the Fractional Order PID controller is better than conventional PID.
Pengelolaan Sampah Plastik Rumah Tangga dalam Rangka Pencegahan Pencemaran Lingkungan (Study di Lingkungan Kelurahan Pedungan Kecamatan Denpasar Selatan Kota Denpasar)
Authors: DWIYANA PUTRA I MADE ODE , Sugiartha I Nyoman Gede , Suryani Luh Putu
Published: March 2021

Plastic waste is a garbage that cannot be degradable and very harmful to environmental health conditions because the garbage is included in non-organic waste. In "household plastic waste management in order to prevent environmental pollution, there is  a  problem in  the waste management of household-generated. The problem is 1) how is the policy of setting the plastic waste management household as an effort to prevent environmental pollution in the village of Pedungan district of Denpasar? 2) What are the factors affecting household plastic waste management in Pedungan village? The method in this study is a type of empirical legal research. The approach to the problem used is a fact approach, a case approach, and a sociological approach. In this research, it aims to be able to know the problem solving and to assess the problem in the management of plastic waste in Pedungan village area about the types of garbage, how to manage plastic waste, and the result of plastic waste. Data collection techniques by observation, interviews, and questionnaires, read books and other literature. Analysis of legal data is analyzed and compiled systematically by using qualitative analysis, by analyzing the data obtained from primary and secondary data sources. The waste management is regulated in Decree No. 660/04/I/2019 on the management structure of Pedungan Asri's garbage Bank as household waste management effort, especially in Pedungan village environment.
Efektivitas Aparatur Sipil Negara dalam Pelayanan Publik Disdukcapil Kota Denpasar
Authors: BALADEVA VIDYASAGARA I PUTU , Putu Widiati Ida Ayu , Putu Suryani Luh
Published: March 2021

When providing government agency services, the most important thing to consider is in what ways  government agencies can  help  the  community to  the  maximum. In  providing community services, efforts need to be made by all employees of government agencies, not only in the "Front Line Office", but also in the "Back Line Office". Making a Family Card (KK) is very important and only the state civil apparatus (ASN) can process the KK, so effectiveness and transparency to the public at 
the Denpasar City Civil Registry Office (Capil) is very important in the process of public service. The formulation of this problem is how is the Disdukcapil public service arrangement in Denpasar? And how is the effectiveness of the Disdukcapil ASN service in Denpasar? The research method uses empirical descriptive. The data is processed by quality method. Data sources in the form of primary data through interviews and  field  observations. The  results showed that  the  Disdukcapil Public Service Arrangement of Denpasar City was civil registration documents such as CoW, Identity Card (KTP), Population Certificate (Suket) of Population including Moving Suket, Birth Suket and Death Suket. The KK is the document that is the most handled in the Disdukcapil City of Denpasar. The effectiveness of the Disdukcapil ASN service in Denpasar City is theoretically good but needs to be improved by the application of a digital system in the procedure of making population documents. Barriers that were found were less responsive at the level of service officers (front line) up to the level of responsible agency. The response to various complaints, aspirations, and expectations of the community was not heard. In addition, the main obstacle is lack of coordination from various service units related to one another. As a result, overlapping or policy conflicts often occur between one service agency and other related service agencies.
Pengendalian Alih Fungsi Lahan Pertanian Pangan Berkelanjutan
Authors: Ayunita Komang Triana , Putu Widiati Ida Ayu , Sutama I Nyoman
Published: March 2021

Indonesia is  a  country consisting of  various islands with an incomparable natural beauty. One of natural charm in Indonesia is green area is rice field. A place where tourists capture photos of those who are amazed by the charm of the rice fields but the more days are increasingly ennoed by the era where the rice field now switches the function of green area into a factory area, housing to the convenience store. The desire of every individual who increasingly wants the day to be more successful but forget how important green sans make the government set a regulation of the restriction of land of rice field and sanctions for someone who intentionally violate Government rules. The rule of government can be realized evenly without any awareness of the community itself, together- just apply an attitude of order of law that makes the government can reorganize the green area that until now still many are switching function . Paddy field beside green area also become place of farmers to try fortune by selling their crops in the form of sweet potatoes, vegetables to rice that become a food staple daily, imagine if one day the country no longer has rice field and continue to buy basic material from the outside make the debt of the country increasingly swollen and green area is one of Indonesia's tourism objects if slow the year is increasingly reduced, also the interest of tourists visit here. The Government also makes regulations that contain protection and empowerment of farmers in the processing of green areas.
Tradisi Manak Salah di Desa Adat Padangbulia Kecamatan Sukasada Kabupaten Buleleng
Authors: ASTARI DEWI NI LUH GEDE , Sukadana I Ketut , Sudibya Diah Gayatri
Published: March 2021

Manak salah is one of the traditions carried out by the indigenous peoples of Padangbulia who assume that the birth of twins (male and female) is a mistake that obliges parents and  babies of  twins to  do  Temporary exile for  three months. It  is  considered contrary to humanity so that the government issued a regional Regulation No. 10 year 1951
about the elimination of indigenous manak salah or buncing. Then the problem that is studied  is  how  the  manak  salah  traditions  are  wrong  in  the  village  of  Padangbulia Indigenous  and  what  are  the  factors  causing  the  implementation of  the  manak  salah tradition in Padangbulia traditional village. The method used is empirical legal research with a legal and sociological approach to the case approach by noting that real legal events occur in the village of Padangbulia as well as the source of legal materials used are primary legal materials and with  the  techniques of  collecting legal  materials through interviews and logging that are analyzed qualitatively in the form of descriptive analysis. Based on the results of the research and analysis can be drawn a conclusion that manak salah in accordance with the belief of the people of Padangbulia with the Lontar Dewa Tatwa and Brahma Sapa used as the basis for the implementation of this tradition since First time. Although it has been abolished the manak salah tradition is still being held to date because of Padangbulia's indigenous peoples belief in the disaster that will occur when this tradition is not implemented.
Tanggung Jawab Pihak Asuransi Terhadap Perjanjian Kredit Bank Dalam Hal Debitur Meninggal Dunia
Authors: Purnama Wati Ni Putu , Ni Luh Made Mahendrawati  , Desak Gde Dwi Arini
Published: March 2021

Credit agreements are usually accompanied by a collateral agreement and an insurance agreement. This insurance agreement is a means of transferring risk for the bank, especially life insurance in the event of a debtor's death, besides credit can also fall to the heirs if the debtor dies before paying off the remaining credit. This study aims to analyze the legal consequences of the Bank's Credit Agreement in the event that the Debtor dies and to find out the responsibility of the Insurance Party for the Bank's Credit Agreement in the event the Debtor dies. This study uses a normative research method with a statutory approach and a conceptual approach. The results show that the legal consequence of the credit agreement in the event that the debtor dies, there are two possibilities, namely that the credit goes to the heirs as regulated in article 833 of the Civil Code (Burgerlijk Wetboek) or the guarantee is executed by the bank, and the second possibility is that the credit is written off due to a life insurance clause or a life insurance agreement with a banker's clause, which means that the insurance company must be responsible for paying off the remaining debts of the debtor who died according to the terms and conditions of the policy, otherwise the interested party can file a summons to sue the insurance company. From this, the conclusion is that the parties must fully understand the contents of the credit agreement made, so that later if this risk occurs, there will be clarity on the payment of the debtor's remaining debt.
Perlindungan Hukum Para Pihak dalam Perjanjian Jual Beli Melalui Media Elektronik
Authors: Pratama Putra Pande Bagus Yoga , I Nyoman Putu Budiartha  , Desak Gde Dwi Arini
Published: March 2021

Electronic commerce (E-commerce is basically an act in which contact online transactions using the internet media, and also the existence of E-Commerce is a promising business alternative to be implemented today. This study aims to analyze the validity of the sale-purchase agreement through the media. electronic or internet according to Law No. 11 of 2008 and knowing the form of legal protection for parties in sale and purchase agreements through electronic media in the event of a failure. The research method used is normative legal research with a bullying approach. wan achievement, the party who is responsible for all legal consequences in the implementation of electronic transactions is if it is done alone, all legal consequences in the execution of the transaction are the responsibility of the transacting parties if it is done by granting power of attorney all legal consequences in the implementation of t Electronic transactions are the responsibility of the attorney if done through an electronic agent. All legal consequences in the implementation of electronic transactions are the responsibility of the electronic agent operators. It's simple if in this case an honest character is needed in good faith, where the seller and the buyer must be honest with each other, there are no parties and are harmed for their benefit only so that a valid agreement occurs, and also the goods being traded do not violate the law in Indonesia, such as sharp weapons, protected animals, human trafficking, and drugs.
Avaliação dos testes rápidos para diagnóstico da dengue no Brasil
Authors:   Departamento de Imunologia, Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil, Cristina Balthazar Guedes Borges Helena , Coelho Adati Marisa ,   Departamento de Imunologia, Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil, Copello Vigo Danielle ,   Departamento de Imunologia, Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil, Furtado de Mendonça Valeria ,   Departamento de Imunologia, Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil, Akio Issobe Marlon ,   Departamento de Imunologia, Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil, Barreto dos Santos Flavia ,   Laboratório de Imunologia Viral, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil, Pereira da Silva Zamith Helena ,   Programa de Pós-Graduação em Vigilância Sanitária, Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brasil
Published: March 2021

Introdução: O aumento do número de casos de dengue no mundo estimulou o desenvolvimento e a disponibilização no mercado nacional e internacional de testes de execução rápida e simples para o diagnóstico da doença. Objetivo: Avaliar a sensibilidade e especificidade diagnóstica de Testes Rápidos (TR) imunocromatográficos para detecção de antígeno (Ag) NS1 e de anticorpos (Ac) das classes G (IgG) e M (IgM) e detecção combinada de Ag e Ac (NS1/ IgG/IgM) do vírus da dengue (DENV), encaminhados para análise prévia no INCQS/Fiocruz, no período de maio de 2016 a dezembro de 2018 para obtenção de registro junto à Anvisa do Brasil. Método: A sensibilidade e a especificidade foram avaliadas frente a painéis de amostras verdadeiramente positivas e verdadeiramente negativas para Ag NS1, Ac IgM e IgG do DENV, painéis de desempenho e padrão internacional do National Institute for Biological Standards and Control/Organização Mundial da Saúde (NIBSC/OMS). Os TR que apresentaram valores de sensibilidade e especificidade superiores ou iguais aos declarados pelos fabricantes foram considerados satisfatórios e os com valores inferiores, insatisfatórios. Resultados: Do total de 32 TR avaliados, 23 (71,9%) foram satisfatórios para sensibilidade e especificidade, destes, nove (39,1%), para NS1, 11 (47,8%) para IgG/IgM e três (13,0%), para os testes combinados NS1/IgG/IgM. Dos nove TR insatisfatórios, quatro (44,4%) foram para detecção de NS1; dois (22,2%), para IgG/IgM e três (33,3%), para NS1/IgG/IgM. Os TR considerados insatisfatórios não foram registrados no Brasil. Conclusões: A análise prévia como prevista na legislação brasileira é de grande importância para a manutenção da qualidade dos TR ofertados ao mercado nacional.