bluuebunny/crossref_metadata_2025 huggingface dataset:
SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN DARI AIR REBUSAN SEGAR, SARI SEGAR, DAN EKSTRAK SEGAR BUAH PEPINO (Solanum muricatum Ait.) DENGAN METODE DPPH
Authors: Harianja Putri Theresia , Daulay Anny Sartika , Ridwanto  , Yuniarti Rafita
Published: May 2023

Radikal bebas adalah suatu molekul atau senyawa yang mampu berdiri sendiri yang mengandung satu atau lebih elektron yang tidak berpasangan pada orbit paling luar. Antioksidan adalah zat yang berfungsi menjaga tubuh dari serangan radikal bebas. Salah satu tanaman yang berpotensi sebagai antioksidan adalah tanaman pepino (Solanum muricatum Ait.) Pada buah pepino terdapat senyawa fitokimia seperti alkaloid, flavonoid, tanin, dan glikosida. Penelitian ini bertujuan untuk mengetahui kekuatan aktivitas antioksidan dari air rebusan segar, sari segar, ekstrak segar buah pepino. Penelitian ini dilakukan dengan metode eksperimental. Sampel yang digunakan adalah buah pepino. Tahapan penelitian meliputi pengumpulan bahan,  pengolahan bahan, identifikasi tumbuhan, pembuatan air rebusan segar, sari segar, dan ekstrak segar buah pepino, skrining fitokimia serta uji  aktivitas antioksidan dengan metode DPPH (1,1-diphenyl-2-picrylhydrazyi). Hasil dari skrining fitokimia air rebusan segar, sari segar, ekstrak segar buah pepino menunjukkan adanya senyawa flavonoid, alkaloid, tanin, dan glikosida dan hasil pemeriksaan uji aktivitas antioksidan air rebusan segar yaitu sebesar 3739,34 µg/mL, sari segar yaitu sebesar 2915,25 μg/mL, dan ekstrak segar buah pepino yaitu sebesar 867,20 μg/mL. Kesimpulan dari penelitian ini bahwa aktivitas antioksidan sampel lebih lemah dari Vitamin C yaitu sebesar 33,67 μg/mL.
PROFIL DISOLUSI TERBANDING TEOFILIN TABLET GENERIK, NAMA DAGANG, DAN SEDIAAN LEPAS LAMBAT
Authors: Muhammad Tegar Tri Rizky  , Gabena Indrayani Dalimunthe  , Minda Sari Lubis  , Rafita Yuniarti
Published: May 2023

Saat ini industri farmasi memproduksi berbagai bentuk sediaan obat. Hal ini membuat kebanyakan masyarakat bingung dalam memilih obat untuk dikonsumsi sesuai kebutuhannya. Padahal berbagai bentuk sediaan obat mempunyai tujuannya masing-masing dalam penggunaannya, diantaranya dengan laju pelepasan berbeda. Dalam hal ini profil laju pelepasan obat sangat penting diperhatikan, mulai dari konsentrasi waktu awal mula obat masuk ke dalam darah sampai habisnya terabsopsi oleh tubuh.

Tujuan  penelitian ini adalah untuk melihat profil disolusi dari teofilin tablet generik, nama dagang, dan sustained release. Uji disolusi untuk melihat laju pelepasan teofilin dari tablet generik, nama dagang, dan lepas lambat dilakukan berbagai waktu dalam medium lambung buatan pH 1,2, dan untuk tablet sustained release juga dilakukan dalam medium berganti, lambung buatan pH 1,2 sampai menit ke 180, dilanjutkan dalam medium usus buatan pH 7,4 sampai menit ke 450.

Laju pelepasan teofilin hasil disolusi pada menit ke 240 dalam medium lambung buatan pH 1,2 menunjukkan pada tablet generik (98,29 ± 0,60)%, nama dagang (99,85 ± 0,80)%, dan sustaind release (50,10 ± 0,69)%. Laju pelepasan teofilin tablet sustained release dalam medium  berganti, medium lambung buatan pH 1,2 pada 180 menit (46,09 ± 0,69)%, dilanjutkan dalam medium usus buatan pH 7,4 sampai 450 menit (99,71 ± 0,79)%. Kesimpulannya tablet teofilin nama dagang lebih cepat terlepas sempurna waktunya dibanding dengan tablet teofilin generik pada rentan waktu 75 menit sedangkan untuk teofilin sediaan lepas lambat membutuhkan waktu 4 jam untuk sediaan tersebut lepas sempurna.
PENENTUAN SPF( Sun Protection Factor ) EKSTRAK ETANOL DAUN ASAM JAWA (Tamarindus indica L.)
Authors: Fitri Febriani  , Rafita Yuniarti  , Gabena Indrayani Dalimunthe  , Minda Sari Lubis
Published: May 2023

Ultraviolet merupakan radikal bebas yang jika berlebihan masuk kedalam kulit dapat menyebabkan kerusakan kulit. Senyawa kimia yang mengandung antioksidan tabir surya dapat melindungi kulit dari pengaruh buruk radikal bebas. Salah satu tumbuhan yang mengandung antioksidan yang tinggi adalah daun asam jawa (Tamarindus indica L). Tujuan penelitian ini adalah untuk mengetahui karakteristik serbuk simplisia daun asam jawa, mengetahui senyawa kimia metabolit sekunder ekstrak etanol daun jawa dan melihat aktivitas tabir surya ekstrak etanol daun asam jawa melalui nilai SPF.

Tahapan penelitian ini meliputi karakteristik simplisia, pembuatan ekstrak, skrining fitokimia, pengujian SPF (Sun Protection Factor) ekstrak etanol daun asam jawa pada konsentrasi 100, 300, 500, 700 dan 1000 ppm.

Hasil karakteristik serbuk daun asam jawa dengan bentuk daun bertangkai pendek, panjang daun 1-2 cm, lebar daun 4-8 mm, tepi daun rata, ujung daun membundar, aroma khas, warna hijau. Kadar air 4,6 %, Kadar sari larut air 37,84 %, Kadar sari larut etanol 25,33 %, Kadar abu 4,51 %, Kadar abu tidak larut asam 1,765 %. Hasil skrining fitokimia ekstrak etanol daun asam jawa mengandung alkaloid, flavonoid, saponin, tanin, dan steroid. Uji SPF memberikan hasil secara berturut 3,470; 8,7; 14,74; 20,89; dan 29,995.
FORMULASI, UJI MUTU FISIK DAN PENENTUAN KADAR VITAMIN C PADA PERMEN BUAH PEPAYA (Carica papaya L.)
Authors: Sagita Marina Simatupang  , Rafita Yuniarti  , Minda Sari Lubis  , Anny Sartika Daulay
Published: May 2023

Buah pepaya memiliki kandungan vitamin A, C, Kalsium dan Serat, selain itu pepaya memiliki sifat yang mudah rusak (perisable) karena tergolong buah klimatrik (buah yang setelah masa panen masih melakukan proses metabolisme). Tujuan penelitian ini adalah untuk memformulasikan sari Buah Pepaya kedalam permen keras dan mengetahui karakteristik mutu fisik permen keras sari Buah Pepaya, dan untuk mengetahui kandungan vitamin C yang terdapat didalam permen keras sari Buah Pepaya. Penelitian ini dilakukan dengan cara membuat permen keras menggunakan sari Buah Pepaya dengan konsentrasi 0%, 20%, 30%, kemudian diuji mutu fisiknya berdasarkan Standar Nasional Indonesia tahun 2008 dan di tentukan kadar vitamin Cnya menggunakan metode Spektrofotometri Ultraviolet. Hasil pembuatan sari Buah Pepaya persyaratan Standar Nasional Indonesia tahun 2008 dengan  hasil uji organoleptis setiap sediaan permen sari buah pepaya didapat hasil yang normal untuk bau, rasa, dan warna serta memiliki tekstur yang keras. Untuk kadar air F0, F1, F2 secara berturut diperoleh sebesar 0, 43%; 1, 37%; 1,21%; dan untuk kadar abu F0, F1, F2 secara berturut diperoleh sebesar 1,2%; 1,3%; 1,6%; Hasil kadar Vitamin C pada formula F0, F1, F2 sebesar 82,3046 ± 9,3451mcg/g; (20%) 105,0739 ± 8,8395  mcg/g; dan (30%) 148,1975 ± 6,3466 mcg/g.
ANALISIS AKTIVITAS ANTIOKSIDAN TEH DAUN JAMBLANG (Syzygium Cumini (L.) Skeels) DENGAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl)
Authors: Cut Erika Maulydya  , Rafita Yuniarti  , Gabena Indrayani Dalimunthe  , Haris Munandar Nasution
Published: May 2023

Jamblang (Syzygium cumini (L.) Skeels) merupakan salah satu tumbuhan famili Myrtaceae yang telah dikenal dan dimanfaatkan sebagai obat tradisional. Kandungan senyawa aktif  tanaman ini adalah   golongan polifenol yang merupakan salah satu sumber antioksidan alami. Radikal bebas didefinisikan sebagai suatu atom atau molekul yang mempunyai satu atau lebih elektron tidak berpasangan pada orbital terluarnya, bersifat sangat reaktif dan tidak stabil. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan teh daun jamblang. Penelitian ini dilakukan dengan metode deskriptif. Sampel yang digunakan adalah daun jamblang. Tahapan penelitian meliputi penyiapan sampel, identifikasi tumbuhan, pembuatan simplisia, pengemasan teh, uji aktivitas antioksidan, pembuatan larutan induk baku DPPH, pembuatan larutan blanko, pembuatan larutan seduhan teh daun jamblang, skrining fitokimia serta menguji aktivitas antioksidan berdasarkan IC50 dengan pembanding vitamin C. Hasil karakterisasi serbuk simplisia diperoleh kadar air 9,164%, kadar abu total 6,60%, kadar abu larut dalam air 3,74%, kadar abu tak larut dalam asam 0,74% dan ekstrak dalam air 34,48%. Hasil skrining fitokimia menunjukan bahwa daun jamblang mengandung senyawa kimia golongan flavonoida, glikosida, tanin, saponin dan triterpenoid/steroida. Hasil analisis aktivitas antioksidan pada daun jamblang memiliki nilai IC50 5,84ppm dan nilai IC50  vitamin C sebesar 34,19 ppm, dimana dari hasil tersebut teh daun jamblang memiliki aktivitas antioksidan sama vitamin C dengan kategori sangat kuat.
Nutzung eines Programms zur Erstellung einer Bewerbung als Bildungsprodukt im Rahmen des Postgraduate Program in Professional and Technological Education (PROFEPT)
Authors: Viana Valderi Nascimento , Fecury Amanda Alves , Oliveira Euzébio de , Dendasck Carla Viana , Dias Claudio Alberto Gellis de Mattos
Published: May 2023

Ziel des Fachmasters ist es, dass der Masterstudierende während des Studiums bis zum Abschluss Probleme lokalisieren, erkennen, identifizieren und lösen kann. Um das ProfEPT abzuschließen, ist es notwendig, am Ende des Kurses ein Lehrprodukt zu erstellen und zu liefern, das im Unterrichtsbereich sofort anwendbar ist. Kodular ist eine Website, die es ermöglicht, Anwendungen auf Basis des Android-Systems mit Blöcken als Programmiersprache zu erstellen. Das Ziel dieses Artikels war es, die Verwendung eines Programms zur Erstellung einer Anwendung als Bildungsprodukt im Rahmen des Graduate Program in Professional and Technological Education (PROFEPT)[6] zu demonstrieren.
METHODS OF PHYSICAL REHABILITATION OF PATIENTS WITH ISCHEMIC STROKE
Authors: Mykhalchuk Nataliia Oleksandrivna , Kharchenko Yevhen Mykolaiovych , Ivashkevych Eduard Zenonovych , Ivashkevych Ernest Eduardovych , Khupavtseva Nataliia Oleksandrivna
Published: May 2023

The purpose of our research is to develop and justify the functional method of using physical rehabilitation tools in restoring the motor functions of patients with ischemic stroke in the area of the internal carotid artery, taking into account the psychological state of the patient, the ontogenetic features of the restoration of his/her postural and dynamic functions, and the biomechanical laws of the formation of compensatory changes in the motor system of the individual. Research methods. In the system of measures for physical rehabilitation of patients with ischemic stroke, one of the most important points it is control of the patient’s level of adaptation capabilities. Risk factors from the side of the cardiovascular system are: the degree of atherosclerosis, arterial hypertension, especially the increase in blood pressure over 200 mm Hg. art and diastolic is – more, than 110 mm Hg. art, increased blood viscosity, blood pressure fluctuations, for example, with heart rhythm disorders. Patients, having been included into the research, were selected by the method of randomization using a Table of random numbers (Paired Design Technology was used by us). Patients of the control group received a complex of rehabilitation measures using physical exercises (according to the classical method, proposed by us. To assess the psychological status of the patient, the eight-color test of M. Lüscher was used. The results of the research. According to all patients of the experimental and control groups, during the entire period of inpatient treatment, the following data were analyzed daily: well-being, frequency and nature of pain sensations, other complaints (shortness of breath, palpitations, sleep and mood disorders, tolerability of restorative treatment procedures). A clinical, functional and psychological examination was conducted for all patients before and after the complex rehabilitation course. Conclusions. The study of the initial state of voluntary motility of ischemic stroke patients at the beginning of the physical rehabilitation course showed the presence of disorders of static and dynamic motor function of the arm, leg, coordinated action of the arms and legs, head, trunk, but quite different in their explanation in the studied groups of patients. The state of motor functions of patients with ischemic stroke is characterized in such a way: on the affected side, the maximum values of the volume of active and passive movements of strength and muscle tone are diagnosed in the “hemiparesis” subgroup, the smallest one – is in the “hemiplesia” subgroup. On the side of the lesion lacuna, the most pronounced muscle strength and tone are diagnosed in the subgroup “hemiparesis”, the largest amount of active and passive movements, in turn, there are in the subgroup “plesia + paresis”, “hemiparesis”.
BLOOD SUPPLING THE TESTICLES IN FERTILE PERIOD OF HUMAN’S LIFE
Authors: Sharapova Olena Mikolaivna
Published: May 2023

In work, the sources of blood supply to the testicle on the way to its moving from the abdominal cavity to the scrotum during the fertile period of a person were investigated. A comparative anatomical assessment of the blood supply to the testicles of some mammals in different periods of their sexual development is also provided. The functional disorders in the human endocrine system at the stages of puberty after the determination of blood hormones were described. On the basis of morphological studies carried out on fetus, variants of the departure of the testicular artery and percentage variants of branching of this artery on the trunk were established. As a result of the study, the largest increase in the diameter of the testicular artery up to 0.7 mm was determined from the 5th to the 7th month of the fertile period of a human’s life, as the variability of the angle of departure of the testicular arteria from the main vessel. Options for branching the testicular artery into distributive and mixed groups are also proposed. The detailed morphological study of the intra-organ bed of the testicle, as a tubular organ, as well as the vessels that blood to the organs surrounding the testicles: epididymes, vas deferens, provides results of the work. In the work, the effect of ligation vessels of the testicle, epididimes and vas deferens on the structure and function of the organs that provide blood supply, the author also investigated. In the course of the experiment, it was proven that cutting the testicular arteries in not sexually immature animals lends to greater destruction of the seminiferous tubules than their ligation in sexually mature animals. As a result of the experiment, the author proposed practical recommendations for operations on the testicles. In particular, to determine of the sectional level of the main feeding vessel responsibility to variants and groups of branching testicular arteries.
ГРУПА ОСОБИСТІСНОГО ЗРОСТАННЯ МЕДИЧНИХ СЕСТЕР ДОШКІЛЬНИХ НАВЧАЛЬНИХ ЗАКЛАДІВ ЯК ІННОВАЦІЙНА ФОРМА РОБОТИ
Authors: Вронська Вікторія Миколаївна
Published: May 2023

У статті висвітлено особливості організації та зміст роботи Групи особистісного зростання на прикладі учасниць – медичних сестер дошкільних навчальних закладів. Враховуючи те, що медичні сестри працюють в дошкільних навчальних закладах, вони повинні знати психологічні особливості дітей дошкільного віку, вміти налагоджувати комунікативну взаємодію з вихованцями, їхніми батьками, фахівцями дошкільного навчального закладу та мати сформовану психологічну компетентність. Висвітлено ситуації, які виникали останнім часом і пов’язані з наданням психологічного супроводу та підтримки (в умовах COVID-19 та в даний час). Проаналізовано результати сучасних експериментальних досліджень, які демонструють психологічні проблеми у фахівців медичних спеціальностей: невпевненість в собі, емоційне ставлення, фрустрованість та ін. Ми обирали доцільні форми роботи, які сприяли б вирішенню означених завдань. Проаналізували груповий підхід спеціаліста з внутрішніх хвороб Масачусетского госпіталю в Бостоні Джозефа Пратта, який першим визнав взаємозв’язок між психологічним станом і фізичним протіканням хвороби і проводив групову психотерапію для людей, які не мають соматичних захворювань. Пізніше в Якоб Леві Морено створив специфічну і достатньо структуровану форму групової терапії – психодраму, елементи якої використовуються в Групі особистісного зростання, яку ми проводили з медичними сестрами дошкільних навчальних закладів. Хоча історично тренінги особистісного зростання започаткував О. Еверетт, зокрема тренінг «Динаміка розуму» (Mind Dynamics), невдовзі з цього тренінгового напряму сформувався процес Лайфспрінг (Lifespring). Зі свого боку, ми брали до уваги і відгуки К. Рудестама, Л. Виготського про особливості тренінгової роботи. В статті висвітлили сутність та етапи роботи Групи особистісного зростання. Подали теоретичний опис та практичні форми проведення тренінгів. Продемонстрували результати інноваційної форми роботи – об’єднання медичних сестер дошкільних навчальних закладів у Групу особистісного зростання.
КОМПЕТЕНТНІСНИЙ ПІДХІД У НАВЧАННІ ІНОЗЕМНОЇ МОВИ СТУДЕНТІВ МЕДИЧНИХ СПЕЦІАЛЬНОСТЕЙ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ
Authors: Чорноус Віра Петрівна
Published: May 2023

У статті досліджено основні теоретичні аспекти компетентнісного підходу навчанні іноземної мови студентів медичних спеціальностей закладів вищої освіти. Проаналізовано різні підходи до трактування понять «компетентність», «комунікативна компетентність», «іншомовна комунікативна компетентність», «компетентнісний підхід». Компетентність визначається як цілісна якість особистості, яка, базуючись на знаннях, уміннях, навичках, особистісних якостях, відображає прагнення, готовність і здатність вирішувати проблеми реальної практичної діяльності. Охарактеризовано основні компоненти іншомовної компетенції: граматичний (словниковий запас, правила правопису, побудова речень); соціолінгвістичний (опису, повідомлення, переконання); дискурсивний (здатність до висловлювання); стратегічний (здатність використовувати вербальні і невербальні засоби). Проаналізовано принципи впровадження компетентнісного підходу у навчанні іноземної мови: принцип раціонального використання словникового мінімуму; принцип спорідненості мовних явищ латинської та англійської мов; принцип спрямованого пред’явлення лексичних одиниць у навчальному процесі; принцип урахування мовних властивостей лексичних одиниць; принцип комплексного вирішення дидактико-методичних задач у галузі навчання лексики. Визначено, що найбільш ефективними технологіями формування іншомовної професійної комунікативної компетентності в навчанні англійської мови є інтерактивні види діяльності. А отже, і діяльність викладача іноземної мови у медичних закладах вищої освіти має супроводжуватись повноцінно підібраними сучасними методами та технологіями навчання, новітніми методиками викладання іноземної мови.
ЦЕНТРАЛЬНИЙ АНТИХОЛІНЕРГІЧНИЙ СИНДРОМ
Authors: Вахновська Христина Іванівна , Шмігач Микола Миколайович
Published: May 2023

У статті розкрита проблема порушення пробудження пацієнта після анестезії, яка зустрічається у практиці кожного анестезіолога. У вигляді психомоторного збудження, м’язового тремору, заторможеного пробудження. Тільки в німецькомовних країнах вищевказані стани об’єднані в один патологічний синдром під назвою Центральний антихолінергічний синдром (ЦАС). Частота ЦАС складає близько 10% при загальній анестезії, а при регіонарній з седацією 3,3%. У відділенні інтенсивної терапії у пацієнтів, які знаходяться на ШВЛ, синдром спостерігається близько 5% від всіх випадків. В іспанській медичній літературі теж періодично згадується ЦАС. В той час як англійські анестезіологи стверджують, що стикають з цим явищем вкрай рідко. З чим же пов’язана така кореляція? Можна стверджувати, що справа не в існуванні чи відсутності ЦАС, а в аналізі симптоматики при пробудженні пацієнта та підході для її купірування.
Improvement of the technology of marshmallow with the addition of plant raw materials
Authors: Artamonova Maiia , Piliugina Inna , Aksonova Olena
Published: May 2023

Every year, the interest in functional nutrition is growing in the world. Consumers are increasingly rejecting products containing sugar, artificial preservatives, dyes, flavorings, flavor enhancers, etc. There is a growing public interest in healthy food products and the ingredients used in these products. Despite the increase in the price of such products, marketing research confirms the demand for them and the willingness of the population to "overpay for naturalness". The article is devoted to the development of the formulation and technology of a pastila-type product with a functional purpose using non-traditional raw materials (coconut sugar, fructose and blueberry powder) instead of sugar. The organoleptic and physicochemical indicators of the quality of new products were determined. The pastila-type products are enriched with protein, dietary fibers, minerals (potassium, calcium, magnesium, zinc) and vitamins (C, PP, groups B, A).
Investigación acción en grupos vulnerables
Authors: Vega Villarreal Sandra
Published: May 2023

El presente documento expone de manera sintética los resultados finales de una investigación – acción que se desarrolló con la participación de interventores educativos y grupos vulnerables procedentes de algunas comunidades del municipio de Satevó Chihuahua. Esta investigación se realizó con la finalidad de que estos grupos, específicamente de mujeres en situación de violencia y comunidades de adultos mayores, pudieran identificar su condición de vulnerabilidad económica, cultural y social, para que, a través de un proceso educativo jerarquicen y delimiten sus problemáticas, y sus condiciones para actuar sobre ellas y desarrollen verdaderamente un proceso educativo liberador. El documento expone los resultados obtenidos en cada una de las etapas vividas en el transcurso de dos años, periodo en que se desarrolló la investigación. La primera etapa que expone brevemente es la etapa previa o de formación del equipo de trabajo, la cual aporta elementos que sirven de pauta para futuras realizaciones de investigación – acción. Posteriormente, se muestran los resultados obtenidos en la etapa de tematización, donde se delimitan participativamente las problemáticas a enfrentar en el siguiente momento de programación – acción que da cuenta de las estrategias planeadas, cuya ejecución se narra en la etapa de acción pedagógica y se valoran en la etapa final, de balance o evaluación. Este documento contiene en su conjunto una serie de elementos teóricos y metodológicos para el desarrollo de proyectos de investigación educativa que conlleven al empoderamiento de los grupos sociales en condiciones de vulnerabilidad para que puedan transformar su realidad.
Sistem Informasi Surat Perintah Perjalanan Dinas pada Dinas Pengendalian Penduduk, Keluarga Berencana, Pemberdayaan Perempuan, Perlindungan Anak dan Pemberdayaan Masyarakat Kota Palangka Raya Berbasis Web
Authors: Pangestu Prayogo , Nugroho Bayu Pratama , Yedithia Fenroy
Published: May 2023

Dengan kemajuan teknologi sekarang ini, sekarang sebagian orang berusaha untuk mengolah suatu sistem komputerisasi yang baik dan mudah dipakai untuk membantu pekerjaan manusia. Berkaitan dengan kemajuan teknologi informasi yang sangat berkembang dimana peneliti membuat Sistem Informasi Surat Perintah Perjalan Dinas Pada Instansi Pemerintah Daerah Berbasis Web, yang dapat membantu pegawai untuk tanpa harus mengetik ulang. Sistem Informasi ini dibangun dengan Metode pengumpulan data yaitu observasi, wawancara, studi pustaka, dokumentasi, dan kuesioner. Metode pengembangan sistem menggunakan pendekatan SDLC. Terdapat berbagai macam model pengembangan SDLC, salah satunya adalah dengan Waterfall Mode. Untuk metode analisis penulis menggunakan metode PIECES. Hasil akhir adalah sebuah Sistem Informasi ini, telah diuji dengan skala likert. Penulis membagikan kuesioner kepada 15 responden dengan 5 pernyataan dan diperoleh perhitungan dengan nilai 93% atau 375 point nilai, termasuk dalam kategori sangat setuju. Sehingga dapat dikatakan bahwa perancangan yang penulis buat telah memenuhi nilai yang baik.
Analisis dan Desain Jaringan Wireless pada SMAN 1 Tanah Siang Selatan Menggunakan Wireshark dan Cisco Packet Tracer
Authors: Pristiandi Lewis , Sam'ani Sam'ani , Rosmiati Rosmiati
Published: May 2023

SMAN 1 Tanah Siang Selatan memiliki jaringan internet WLAN yang digunakan pada area sekolah kapasitas kecepatan 20 Mbps. Berdasarkan hasil wawancara yang telah penulis lakukan dapat diketahui bahwa koneksi internet tidak stabil dikarenakan banyaknya pengguna yang terhubung ke jaringan wireless disaat bersamaan, serta SMAN 1 Tanah Siang Selatan belum pernah melakukan pengukuran parameter QoS untuk mengetahui kualitas kinerja jaringan apakah jaringan wireless dalam kondisi bagus atau sebaliknya. Penelitian ini bertujuan untuk mengetahui kualitas kinerja jaringan apakah jaringan wireless dalam kondisi bagus atau sebaliknya dengan menggunakan metode analisis QoS dengan parameter (throughput, delay, packet loss) dan menggunakan software analisis jaringan yaitu Wireshark. Jenis penelitian yang akan digunakan penulis dalam penelitian ini adalah penelitan tindakan (action research). Metode pengumpulan data yaitu observasi, wawancara, dan kepustakaan. Penulis memberikan rekomendasi desain topologi jaringan yang nantinya dapat dijadikan sebagai referensi atau acuan untuk membangun dan pengembangan jaringan LAN pada SMAN 1 Tanah Siang Selatan nantinya.
Perancangan Panduan Wisata Kalimantan Tengah dengan Permodelan Air Terjun Berbasis Android
Authors: Haris Qamaruzzaman Muhammad , Sam'ani Sam'ani
Published: May 2023

Tahapan perancangan merupakan bagian terpenting sebelum sebuah aplikasi dibangun. Untuk membantu masyarakat dapat mengetahui informasi pariwisata yang ada di Kalimantan Tengah terlebih bagi yang berasal dari luar provinsi, maka dibutuhkan  suatu media informasi berupa panduan wisata yang dapat digunakan dimana dan kapan saja yang dapat menyajikan informasi mengenai berbagai macam keterangan seperti objek wisata, sarana wisata, dan sebagainya. Perancangan penelitian ini menggunakan metode pengembangan perangkat lunak System Development Life Cycle (SDLC) dengan pendekatan pengembangan model air terjun (waterfall). Hasil penelitian ini berupa perancangan sistem yang akan menyajikan informasi panduan wisata Kalimantan Tengah dengan permodelan air terjun berbasis android secara visual yang akan dijadikan dasar untuk membangun aplikasi sistem informasi panduan wisata.
Editorial: O Trabalho e as Violências
Authors: Muradas Daniela , Romero Rodenas Maria Jose , Barreto Ghione Hugo
Published: May 2023

Editorial de apresentação do Dossiê Trabalho e Violências.
PERSELISIHAN PEMUTUSAN HUBUNGAN KERJA DALAM HUBUNGAN INDUSTRIAL DI KOTA TANGERANG
Authors: Yusuf Yusmedi , Myranika Annie
Published: May 2023

Employment developments in Indonesia, influenced by the Industrial Relations between Government and Employers. Industrial relations are needed in the protection of workers in each company. Employment law in legislation, contracts, and cooperative agreements are continuing to experience the dynamics change in industrial relations. Employment issues in Indonesia often arise in industrial relations disputes in particular the case of termination of employment (FLE) unilaterally by the company. Industrial disputes due to layoffs, require the law enforcement aspect through the regulation of Law No.13 of 2003 on Manpower, and Law No.2 of 2004 on Industrial Relations Dispute Settlement. In its implementation, these laws and regulations have not reached the disputing parties, so that problem solving often results in disputes between workers and employers, and the government. This research method use a normative juridical. Primary data and csecondary data were analyzed qualitatively. The bipartite layoff settlement between the company and the workers, in its implementation, has met with many failures in the bargaining process. Department of Labor has attempted to implement Law No.13 of 2003 and Law No.2 of 2004 on Mayor Regulation No.64 of 2016 as an implementation of the mediation settlement. However, the data in the field shows the implementation has not been effective, because industrial dispute settlement case takes approximately 6 months (180 days), exceeds the provisions in Law No.2 of 2004.Keywords: Labor; Industrial Relation; Dispute
KONSEP KEADILAN DAN HUKUM DALAM PERSPEKTIF FILSAFAT HUKUM
Authors: Ramadhani Prista Alisa , . Rasji
Published: May 2023

Law and justice are basically abstract, but not only based on the scope of philosophical study. Legal science always fights for justice. In reality, there is often a clash between legal certainty and expediency, or between justice and legal certainty, between justice and expediency. Talking about law and justice has to do with how justice can be implemented in the law itself. The law as the embodiment of the developed value referred to in this case is justice. The legal research method used is doctrinal. The embodiment of the value of justice is the existence of rights and obligations that can be fulfilled by the community itself. Where there is a rule of law, there are rights and obligations that govern it to create order and justice in society. The relationship between law and justice can be realized if the people themselves feel it. Laws and statutory regulations are basically symbols that are intrinsically and ideally containing truth and justice. Paradigm of legal positivism, justice is seen as a goal rather than law. Justice is seen as a goal rather than law, it's just that relativity often ignores another element, namely the element of legal certainty.

Keywords: Philosophy Law, Justice, law
Agroecological assessment of short crop rotation on sod-podzolic soil
Authors: Savchuk O. , Prуіmachuk T. , Drebot O. , Tsuman N. , Ilyinsky Yu.
Published: May 2023

In the conditions of drained lands with unsatisfactory work of reclamation systems, in the Polissia zone it became possible to grow commercially attractive crops, in particular, such as winter rapeseed and corn for grain. A short-rotation crop rotation was analyzed: lupine — winter rapeseed — winter rye — corn, on the basis of which various variants of the fertilization system were studied, including by replacing litter manure with siderate and by-products of all crops in combination with the recommended for the zone and increased (intensive) mineral norms fertilizers. The goal of the task was to determine the optimal agrochemical support for grain crop rotation to obtain stable crop productivity and preserve soil fertility. It was noted that during the 2016–2020 research, during the growing season of agricultural crops, the reserves of productive moisture in the meter-long layer of drained sod-podzolic sandy soil decreased to 60–80 mm, that is, to a critical level. It was established that the overall productivity of the crop rotation depended on its saturation with corn, the grain yield of which was 6.01–7.13 t/ha on average over 5 years at different levels of organic and mineral nutrition. The highest yield of grain and fodder units from 1 ha of crop rotation area (4.23 and 4.52 tons, respectively) was obtained when by-products were applied together with an increased rate of mineral fertilizers (N67P84K91). It was established that the replacement of litter manure with the by-products of grain, leguminous and oilseed crops as an organic fertilizer, together with the use of the recommended (N45P56K61) and increased (N67P84K91) mineral fertilizer rates, does not reduce the productivity of crop rotation, ensures a deficit-free nitrogen balance and the annual accumulation of humus in the amount of 320 and 440 kg, respectively, which guarantees extended reproduction and increased soil fertility.
The association between higher FFAs and high residual platelet reactivity among CAD patients receiving clopidogrel therapy
Authors: Zhao Zehao , Dong Shutong , Sun Tienan , Han Kangning , Huang Xin , Ma Meishi , Yang Shiwei , Zhou Yujie
Published: May 2023

Background

Metabolic abnormalities are associated with the occurrence, severity, and poor prognosis of coronary artery disease (CAD), some of which affect the antiplatelet efficacy of clopidogrel. Free fatty acids (FFAs) is a biomarker for metabolic abnormalities, and elevated FFAs is observed among CAD patients. Whether FFAs enhances residual platelet reactivity induced by adenosine diphosphate (ADP) while using clopidogrel was unknown. The purpose of our study is exploring the issue.

Method

Current study included 1,277 CAD patients using clopidogrel and used logistic regression to detect whether the higher level of FFAs is associated with high residual platelet reactivity (HRPR). We additionally performed subgroup and sensitivity analyses to evaluate the stability of the results. We defined HRPR as ADP-induced platelet inhibition rate (ADPi) < 50% plus ADP-induced maximum amplitude (MAADP) > 47 mm.

Results

486 patients (38.1%) showed HRPR. The proportion of HRPR among patients with higher FFAs (>0.445 mmol/L) is greater than among patients with lower FFAs (46.4% vs. 32.6%, P < 0.001). Multivariate logistic regression demonstrated that higher FFAs (>0.445 mmol/L) is independently associated with HRPR (adjusted OR = 1.745, 95% CI, 1.352–2.254). After subgroup and sensitivity analyses, the results remained robust.

Conclusion

The higher level of FFAs enhances residual platelet reactivity induced by ADP and is independently associated with clopidogrel HRPR.
Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia
Authors: Abohamr Samah I. , Abazid Rami M. , Alhumaid Mohammed K. , Abdulrahim Abubaker E. , Aldossari Mubarak A. , Khedr Lamiaa , Werida Rehab H. , Alkheledan Haifa S. , Aleid Yazeed S. , Abdelhamid Sara W. , Al Mefarrej Abdulmohsen , Abdelhamid Ahmed W. , Alaboud Mohammad Hasan , Alhasan Omar T. , Gomaa Hanem M. , Elsheikh Eman
Published: May 2023

Background

Respiratory infections are one of the most common comorbidities identified in hospitalized patients. The coronavirus disease 2019 (COVID-19) pandemic greatly impacted healthcare systems, including acute cardiac services.

Aim

This study aimed to describe the echocardiographic findings of patients with COVID-19 infections and their correlations with inflammatory biomarkers, disease severity, and clinical outcomes.

Methods

This observational study was conducted between June 2021 and July 2022. The analysis included all patients diagnosed with COVID-19 who had transthoracic echocardiographic (TTE) scans within 72 h of admission.

Results

The enrolled patients had a mean age of 55.6 ± 14.7 years, and 66.1% were male. Of the 490 enrolled patients, 203 (41.4%) were admitted to the intensive care unit (ICU). Pre-ICU TTE findings showed significantly higher incidence right ventricular dysfunction (28 [13.8%] vs. 23 [8.0%]; P = 0.04) and left ventricular (LV) regional wall motion abnormalities (55 [27.1%] vs. 29 [10.1%]; p < 0.001) in ICU patients compared to non-ICU patients. In-hospital mortality was 11 (2.2%), all deaths of ICU patients. The most sensitive predictors of ICU admission (p < 0.05): cardiac troponin I level (area under the curve [AUC] = 0.733), followed by hs-CRP (AUC = 0.620), creatine kinase-MB (AUC = 0.617), D-dimer (AUC = 0.599), and lactate dehydrogenase (AUC = 0.567). Binary logistic regression showed that reduced LV ejection fraction (LVEF), elevated pulmonary artery systolic pressure, and dilated right ventricle were echocardiographic predictors of poor outcomes (p < 0.05).

Conclusion

Echocardiography is a valuable tool in assessing admitted patients with COVID-19. Lower LVEF, pulmonary hypertension, higher D-dimer, C-reactive protein, and B-type natriuretic peptide levels were predictors of poor outcomes.
Mid-term safe and effective profile of the Magmaris scaffold in percutaneous coronary intervention: a prospective, single-center study
Authors: Truong Binh Quang , Tran Hoa , Nguyen Vinh Xuan , Nguyen Chinh Duc , Nguyen Khang Duong , Vu Vu Hoang
Published: May 2023

Introduction

Significant advances have been made in the diagnosis and treatment of coronary artery disease over the years. New generations of scaffolds containing novel material and eluting drug have produced one of the most significant advancements in coronary intervention. The newest generation would be Magmaris with a magnesium frame and a sirolimus cover.

Methods

From July 2018 to August 2020, 58 patients treated with Magmaris at the University Medical Center Ho Chi Minh City were enrolled in this study.

Results

A total of 60 lesions were stented, 60.3% of which were left anterior descending (LAD) lesions. There was no in-hospital event. Within 1 year after discharge, we noted one myocardial infarction event that required target-lesion revascularization, one stroke event, one non-target-lesion revascularization patient, two target-vessel revascularization patients, and one in-stent thrombosis. Among them, one myocardial infarction occurrence, one non-target-lesion revascularization, and one in-stent thrombosis event were recorded within the first 30 days after discharge.

Conclusion

In conclusion, the Magmaris scaffold is a safe and effective option for structural procedures performed with imaging device support, particularly intravascular ultrasound.
Can prebiotics help tackle the childhood obesity epidemic?
Authors: Wang Yaqin , Salonen Anne , Jian Ching
Published: May 2023

Globally, excess weight during childhood and adolescence has become a public health crisis with limited treatment options. Emerging evidence suggesting the involvement of gut microbial dysbiosis in obesity instills hope that targeting the gut microbiota could help prevent or treat obesity. In pre-clinical models and adults, prebiotic consumption has been shown to reduce adiposity partially via restoring symbiosis. However, there is a dearth of clinical research into its potential metabolic benefits in the pediatric population. Here, we provide a succinct overview of the common characteristics of the gut microbiota in childhood obesity and mechanisms of action of prebiotics conferring metabolic benefits. We then summarize available clinical trials in children with overweight or obesity investigating the effects of prebiotics on weight management. This review highlights several controversial aspects in the microbiota-dependent mechanisms by which prebiotics are thought to affect host metabolism that warrant future investigation in order to design efficacious interventions for pediatric obesity.
Case report: A combination of mirror therapy and magnetic stimulation to the sacral plexus relieved phantom limb pain in a patient
Authors: Deng Chunchu , Li Qian
Published: May 2023

Phantom limb pain (PLP) is a common sequela of amputation, experienced by 50-80% of amputees. Oral analgesics as the first-line therapy have limited effects. Since PLP usually affects activities of daily living and the psychological conditions of patients, effective treatments are imperatively needed. In this case study, a 49-year-old man was admitted to our hospital because of uncontrollable paroxysmal pain in his missing and residual leg. Due to severe injuries in a truck accident, the right lower limb of the patient was surgically amputated ~5 years ago. Around 1 month after amputation, he felt pain in his lost leg and PLP was diagnosed. Then, he started taking oral analgesics, but the pain still occurred. After admission on July 9, 2022, the patient received treatments of mirror therapy and magnetic stimulation to the sacral plexus. 1-month treatments reduced the frequency and intensity of pain in the phantom limb and the stump, without any adverse events. Analysis of high-resolution three-dimensional T1-weighted brain volume images at the end of 2-month treatments showed alterations in the thickness of cortex regions related to pain processing, compared to that before treatment. This case study gives us hints that one or both interventions of mirror therapy and sacral plexus magnetic stimulation effectively relieved PLP and stump limb pain. These non-invasive, low-cost and easily conducted treatments could be good options for PLP. But randomized controlled trials with a large number of cases are required to confirm their efficacy and safety.
Matrix disequilibrium in Alzheimer’s disease and conditions that increase Alzheimer’s disease risk
Authors: Amontree Matthew , Deasy Samantha , Turner R. Scott , Conant Katherine
Published: May 2023

Alzheimer’s Disease (AD) and related dementias are a leading cause of death globally and are predicted to increase in prevalence. Despite this expected increase in the prevalence of AD, we have yet to elucidate the causality of the neurodegeneration observed in AD and we lack effective therapeutics to combat the progressive neuronal loss. Throughout the past 30 years, several non-mutually exclusive hypotheses have arisen to explain the causative pathologies in AD: amyloid cascade, hyper-phosphorylated tau accumulation, cholinergic loss, chronic neuroinflammation, oxidative stress, and mitochondrial and cerebrovascular dysfunction. Published studies in this field have also focused on changes in neuronal extracellular matrix (ECM), which is critical to synaptic formation, function, and stability. Two of the greatest non-modifiable risk factors for development of AD (aside from autosomal dominant familial AD gene mutations) are aging and APOE status, and two of the greatest modifiable risk factors for AD and related dementias are untreated major depressive disorder (MDD) and obesity. Indeed, the risk of developing AD doubles for every 5 years after ≥ 65, and the APOE4 allele increases AD risk with the greatest risk in homozygous APOE4 carriers. In this review, we will describe mechanisms by which excess ECM accumulation may contribute to AD pathology and discuss pathological ECM alterations that occur in AD as well as conditions that increase the AD risk. We will discuss the relationship of AD risk factors to chronic central nervous system and peripheral inflammation and detail ECM changes that may follow. In addition, we will discuss recent data our lab has obtained on ECM components and effectors in APOE4/4 and APOE3/3 expressing murine brain lysates, as well as human cerebrospinal fluid (CSF) samples from APOE3 and APOE4 expressing AD individuals. We will describe the principal molecules that function in ECM turnover as well as abnormalities in these molecular systems that have been observed in AD. Finally, we will communicate therapeutic interventions that have the potential to modulate ECM deposition and turnover in vivo.
An anesthesia protocol for robust and repeatable measurement of behavioral visceromotor responses to colorectal distension in mice
Authors: Zhang Shaopeng , Chen Longtu , Feng Bin
Published: May 2023

Introduction

Visceral motor responses (VMR) to graded colorectal distension (CRD) have been extensively implemented to assess the level of visceral pain in awake rodents, which are inevitably confounded by movement artifacts and cannot be conveniently implemented to assess invasive neuromodulation protocols for treating visceral pain. In this report, we present an optimized protocol with prolonged urethane infusion that enables robust and repeatable recordings of VMR to CRD in mice under deep anesthesia, providing a two-hour window to objectively assess the efficacy of visceral pain management strategies.

Methods

During all surgical procedures, C57BL/6 mice of both sexes (8–12 weeks, 25–35 g) were anesthetized with 2% isoflurane inhalation. An abdominal incision was made to allow Teflon-coated stainless steel wire electrodes to be sutured to the oblique abdominal musculature. A thin polyethylene catheter (Φ 0.2 mm) was placed intraperitoneally and externalized from the abdominal incision for delivering the prolonged urethane infusion. A cylindric plastic-film balloon (Φ 8 mm x 15 mm when distended) was inserted intra-anally, and its depth into the colorectum was precisely controlled by measuring the distance between the end of the balloon and the anus. Subsequently, the mouse was switched from isoflurane anesthesia to the new urethane anesthesia protocol, which consisted of a bout of infusion (0.6 g urethane per kg weight, g/kg) administered intraperitoneally via the catheter and continuous low-dose infusion throughout the experiment at 0.15–0.23 g per kg weight per hour (g/kg/h).

Results

Using this new anesthesia protocol, we systematically investigated the significant impact of balloon depth into the colorectum on evoked VMR, which showed a progressive reduction with increased balloon insertion depth from the rectal region into the distal colonic region. Intracolonic TNBS treatment induced enhanced VMR to CRD of the colonic region (>10 mm from the anus) only in male mice, whereas colonic VMR was not significantly altered by TNBS in female mice.

Discussion

Conducting VMR to CRD in anesthetized mice using the current protocol will enable future objective assessments of various invasive neuromodulatory strategies for alleviating visceral pain.
Risk and promise: an 11-year, single-center retrospective study of severe acute GVHD in pediatric patients undergoing allogeneic HSCT for nonmalignant diseases
Authors: Zaidman Irina , Even-Or Ehud , Aharoni Elroee , Averbuch Dina , Dinur-Schejter Yael , NaserEddin Adeeb , Slae Mordechai , Shadur Bella , Stepensky Polina
Published: May 2023

Background

Hematopoietic stem cell transplantation (HSCT) is the only curative option for many nonmalignant hematopoietic-derived diseases in pediatric patients. Survival after HSCT has improved in recent years and resulted in a 90% survival rate and cure in some nonmalignant diseases. Graft-vs.-host disease (GVHD) remains a frequent and major complication of HSCT, and a leading cause of morbidity and mortality. Prognosis of patients with high-grade GVHD is dismal, with survival rates varying from 25% in the adult population to 55% in pediatric patients.

Methods

The main aim of this study is to evaluate the incidence, risk factors, and outcome of severe acute GVHD (AGVHD) in pediatric patients with nonmalignant diseases, following allogeneic HSCT. Clinical and transplant data were retrospectively collected for all pediatric patients who underwent allogeneic HSCT for nonmalignant diseases at the Hadassah Medical Center between 2008 and 2019. Patients who developed severe AGVHD were compared with those who did not.

Results

A total of 247 children with nonmalignant diseases underwent 266 allogeneic HSCTs at Hadassah University Hospital over an 11-year period. Seventy-two patients (29.1%) developed AGVHD, 35 of them (14.1%) severe AGVHD (grade 3–4). Significant risk factors for developing severe AGVHD were unrelated donor (p < 0.001), mismatch donor (p < 0.001), and the use of peripheral blood stem cells (PBSCs) (p < 0.001). Survival rates of pediatric patients with severe AGVHD was 71.4%, compared with 91.9% among those with mild (grade 1–2) AGVHD and 83.4% among patients without AGVHD (p = 0.067).

Conclusions

These results demonstrate a high survival rate in pediatric patients with nonmalignant diseases despite severe GVHD. Significant mortality risk factors found in these patients were the source of donor PBSC (p = 0.016) and poor response to steroid treatment (p = 0.007).