bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteomic analysis of the chemosensitizing effect of curcumin on CRC cells treated with 5-FU
Authors: Yang Jingbo , He Chengyan , Liu Ning
Published: November 2022

Background

5-Fluorouracil (5-FU) is one of the most common chemotherapy drugs used to treat colorectal cancer (CRC), which often develops resistance in more than 15% of patients. Curcumin, an active component of Curcuma longa, has been reported to show antitumor activity in CRC and, furthermore, enhance the effect of chemotherapy against colorectal cancer cells. However, the molecular mechanisms underlying the sensitizing effect of curcumin on 5-FU have not been largely elucidated. In this study, we aimed to systematically investigate the role of curcumin as a chemosensitizer for the treatment of CRC, along with the key events responsible for its pharmaceutical effect, which may lead to better clinical outcomes.

Methods

A high-resolution 2DE-based proteomics approach was used to characterize global protein expression patterns in CRC cells treated with 5-FU both in combination with curcumin or without. The differentially expressed proteins were obtained from the 2DE analysis and subsequently identified by MALDI-TOF MS or nano-ESI-MS/MS, some of which were validated by the Western blot. Intracellular reactive oxygen species (ROS) were measured to assess the change in the redox environment resulting from the drug treatment.

Results

A series of proteins with altered abundances were detected and identified by MALDI-TOF or nano-MS/MS. From a total of 512 isolated proteins, 22 proteins were found to be upregulated and 6 proteins were downregulated. Intracellular ROS was significantly elevated after curcumin treatment. Furthermore, mass spectrometry data revealed that some of the proteins appeared to have more oxidized forms upon curcumin treatment, suggesting a direct role for ROS in the chemosensitizing effect of curcumin.

Conclusion

The effect of curcumin in enhancing chemosensitivity to 5-FU is a complex phenomenon made up of several mechanisms, including enhancement of the intracellular level of ROS. Our findings presented here could provide clues for a further study aimed at elucidating the mechanisms underlying the chemosensitizing effect of curcumin.
Masked face is looking at me: Face mask increases the feeling of being looked at during the COVID-19 pandemic
Authors: Liu Jiakun , Yang Jiajia , Huang Lihui , Zhou Li , Xie Jinxi , Hu Zhonghua
Published: November 2022

Background

As the COVID-19 global pandemic unfolded, governments recommended wearing face masks as a protective measure. Recent studies have found that a face mask influences perception; but how it affects social perception, especially the judgment of being looked at, is still unknown. This study investigated how wearing a mask influences the judgment of gaze direction by conducting a cone of direct gaze (CoDG) task.

Methods

In Experiment 1, three types of masked faces were considered to investigate whether the effect of masks on CoDG is modulated by mask types. Experiment 2 was to further validate the results of Experiment 1 by adding a learning phase to help participants better distinguish N95 and surgical masks. Furthermore, to investigate whether the effect of masks derives from its social significance, a face with only the eye-region (a mouth-cut face) was used as the stimuli in Experiment 3.

Results

The results of Experiment 1 found that wearing masks widens the CoDG, irrespective of the mask type. Experiment 2 replicated the results of Experiment 1. Experiment 3 found that the CoDG of N95-masked faces was wider than the mouth-cut and non-masked faces, while no significant difference existed between the CoDG of mouth-cut and non-masked faces, illustrating that the influence of wearing masks on CoDG was due to high-level social significance rather than low-level facial feature information.

Conclusion

The results show that face mask increases the feeling of being looked at during the COVID-19 Pandemic. The present findings are of significance for understanding the impact of wearing masks on human social cognition in the context of COVID-19.
The effect of heating method on the gel structures and properties of surimi prepared from Bombay duck (Harpadon nehereus)
Authors: Li Mingao , Yang Jing , Bao Hongli , Chen Yi , Gao Yuanpei , Deng Shanggui
Published: November 2022

This study investigates the effects of heating method, setting time, and setting temperature on the gel properties, water holding capacity (WHC), molecular forces, protein composition, protein conformation, and water transition of Bombay duck (BD) surimi gel. The obtained results demonstrate that the best gel properties are obtained by two-step heating at 30°C for 120 min while the hardness was 10.418 N and the breaking force was 4.52 N. Gel softening occurs at setting temperatures greater than 40°C due to the effect of endogenous enzymes in destroying the protein structure and increasing the hydrophobic and disulfide interactions. Low-field nuclear magnetic resonance spectra confirm that high two-step setting temperatures induce gel softening and the destruction of the surimi gel structure, as evidenced by the increased water migration at these temperatures. Of all protein conformations in the gel, the β-sheet structure, decreases from 38.40% at 30°C to 11.75% at 60°C when the setting time is 60 min, is the most susceptible to gel softening. Overall, the data reported herein provide a scientific basis for the development of new BD surimi products on an industrial level.
Case Report: Differential diagnosis for tuberous sclerosis and neurofibromatosis type 1 diagnostic pitfall of aggressively enlarged right upper limb
Authors: Wei Cheng-Jiang , Peng Li-Ling , Chuang Man-Hon , Wang Zhi-Chao , Wang Bin
Published: November 2022

Tuberous sclerosis complex (TSC) is an inherited disorder that typically presents with seizures, developmental delay, cutaneous lesions, and facial angiomas. Clinical diagnosis of TSC based on symptoms is sometimes challenging due to its clinical similarities with neurofibromatosis type 1 (NF1), another type of neurogenetic tumor syndrome. Differential diagnosis should be carefully performed on the basis of clinical presentations, imaging, laboratory, and genetic testing. Here, we presented a case of a patient with an aggressively enlarged right upper limb in the NF1 clinic, who was initially suspected of a giant plexiform neurofibroma. However, differential diagnosis revealed TSC as the final diagnosis. The treatments for NF1 and TSC vary significantly, and misdiagnoses can lead to serious threat to the patients’ health. We also systematically reviewed all previous cases regarding differential diagnoses between NF1 and TSC. This case report can help clinicians make more accurate diagnoses and benefit the potential patient community.
Evaluation of diagnostic efficacy of multimode ultrasound in BI-RADS 4 breast neoplasms and establishment of a predictive model
Authors: Chen Yunhao , Lu Juerong , Li Jie , Liao Jingtang , Huang Xinyue , Zhang Bo
Published: November 2022

Objectives

To explore the diagnostic efficacy of ultrasound (US), two-dimensional and three-dimensional shear-wave elastography (2D-SWE and 3D-SWE), and contrast-enhanced ultrasound (CEUS) in breast neoplasms in category 4 based on the Breast Imaging Reporting and Data System (BI-RADS) from the American College of Radiology (ACR) and to develop a risk-prediction nomogram based on the optimal combination to provide a reference for the clinical management of BI-RADS 4 breast neoplasms.

Methods

From September 2021 to April 2022, a total of 104 breast neoplasms categorized as BI-RADS 4 by US were included in this prospective study. There were 78 breast neoplasms randomly assigned to the training cohort; the area under the receiver-operating characteristic curve (AUC), 95% confidence interval (95% CI), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 2D-SWE, 3D-SWE, CEUS, and their combination were analyzed and compared. The optimal combination was selected to develop a risk-prediction nomogram. The performance of the nomogram was assessed by a validation cohort of 26 neoplasms.

Results

Of the 78 neoplasms in the training cohort, 16 were malignant and 62 were benign. Among the 26 neoplasms in the validation cohort, 6 were malignant and 20 were benign. The AUC values of 2D-SWE, 3D-SWE, and CEUS were not significantly different. After a comparison of the different combinations, 2D-SWE+CEUS showed the optimal performance. Least absolute shrinkage and selection operator (LASSO) regression was used to filter the variables in this combination, and the variables included Emax, Eratio, enhancement mode, perfusion defect, and area ratio. Then, a risk-prediction nomogram with BI-RADS was built. The performance of the nomogram was better than that of the radiologists in the training cohort (AUC: 0.974 vs. 0.863). In the validation cohort, there was no significant difference in diagnostic accuracy between the nomogram and the experienced radiologists (AUC: 0.946 vs. 0.842).

Conclusions

US, 2D-SWE, 3D-SWE, CEUS, and their combination could improve the diagnostic efficiency of BI-RADS 4 breast neoplasms. The diagnostic efficacy of US+3D-SWE was not better than US+2D-SWE. US+2D-SWE+CEUS showed the optimal diagnostic performance. The nomogram based on US+2D-SWE+CEUS performs well.
Presence of cerebral microbleeds is associated with cognitive decline in acromegaly
Authors: Xie Zhengxing , Zhuang Yan , Zhang Zongqiang , Liu Jieping
Published: November 2022

Background

Cognitive decline in acromegaly has gained increasing attention. Cerebral microbleeds (CMBs) as radiographic markers for microvascular injury have been linked to various types of cognitive decline. However, the association between CMB formation and acromegaly has not yet been quantified. This study is designed to investigate the prevalence and the radiographic patterns of CMBs and the association between cognitive function and acromegaly-related CMBs in growth hormone (GH)-secreting pituitary adenoma, which is characterized by acromegaly.

Methods

In a cohort of 55 patients with GH-secreting pituitary adenoma (acromegaly) and 70 healthy control (HC) patients, we determined the presence of CMBs using a 3.0-T MRI scanner. The numbers, locations, and grades of CMBs were determined via susceptibility-weighted imaging (SWI) and the Microbleed Anatomical Rating Scale. Obstructive sleep apnea (OSA) was assessed using the criteria of the American Academy of Sleep Medicine (AASM) Scoring Manual Version 2.2. The Montreal Cognitive Assessment (MoCA) was used to assess cognitive performance within 3 days of admission. The association between CMBs and cognitive function as well as clinical characteristics was explored.

Results

The incidence of CMBs was 29.1%, whereas that of OSA was 65.5% in acromegaly. There was a statistically significant difference in the prevalence of CMBs between subjects with and without acromegaly (29.1% and 5.3%, respectively) (p < 0.01). The age of acromegaly patients with CMBs was much younger compared with HCs with CMBs. Compared with HCs, a significant cognitive decline and the occurrence of OSA were demonstrated in patients with acromegaly (p < 0.01). Binary logistic regression analysis adjusted for age, education, and body mass index (BMI) revealed that CMB was an independent risk factor for cognitive impairment in patients with acromegaly (OR = 3.19, 95% CI 1.51–6.76, p = 0.002). Furthermore, in the logistic regression models adjusted for age, BMI, diabetes, and hypertension, OSA was independently associated with the occurrence of CMBs in patients with acromegaly (OR = 13.34, 95% CI 3.09–57.51, p = 0.001).

Conclusions

A significant increase of CMBs was demonstrated in patients with acromegaly, which may be a result of OSA in acromegaly. The present study indicated that increasing CMBs are responsible for cognitive decline in patients with acromegaly.
Reconstruction of the coronoid process with the olecranon tip for chronic elbow dislocation in children: A rare case report and literature review
Authors: Jiang Yikun , Qi Le , Peng Chuangang , Li Qiwei , Zhang Peng , Wang Yanbing , Wu Dankai
Published: November 2022

The coronoid process of the ulna, as a key part of the elbow joint, plays an important role in maintaining elbow joint stability. Reconstruction of the coronoid process is necessary in both acute and chronic coronoid defects to restore elbow stability and avoid early joint degeneration. The olecranon tip may be a useful autologous osteochondral graft for reconstructing the same shape of the ulna coronoid process. The purpose of this report was to verify if reconstruction of the coronoid process with the olecranon tip can restore elbow stability and kinematics. Here, we report a 13-year-old boy who had undergone Kirschner-wire fixation for a left supracondylar fracture of the left humerus 9 years previously. After that, the right elbow dislocation and varus deformity gradually appeared. Imaging revealed posterolateral dislocation of the left elbow due to the absence of the coronoid process of the ulna. We reconstructed the ulnar coronoid process by intercepting the ipsilateral olecranon tip. After 22 months of follow-up, the range of motion of the left elbow joint was normal, and the cubitus varus deformity disappeared. The results of this report suggest that olecranon tip autografts are suitable to replace transverse coronoid defects. Given the patient's satisfactory clinical results, this reconstruction technique is safe and effective for the treatment of chronic elbow instability due to coronoid process defects of the ulna.
Hepatoprotective effect of botanical drug formula on high-fat diet-induced non-alcoholic fatty liver disease by inhibiting lipogenesis and promoting anti-oxidation
Authors: Ning De-Shan , Chen Yu-Ju , Lin Chien-Ju , Wang Ching-Chiung , Zhao Hong-Wei , Wang Kun-Teng , Lee Ming-Chung , Tayo Lemmuel L. , Chiu Wan-Chun , Yeh Chiu-Li , Lee Chia-Jung
Published: November 2022

With the prevalence of obesity and other components of metabolic syndrome, Non-alcoholic fatty liver disease (NAFLD) has become increasingly common. In recent years, much attention has been paid to various plant sources, hoping to find a treatment for NAFLD in plants. The Livsooth authentic herbal formula (LAH, 樂悠本草), a botanical drug formula combined with Puerariae lobatae radix, Lonicerae japonicae flos, Hoveniae semen, and Siraitiae fructus. This study used a network pharmacology approach to predict the potential mechanisms of LAH against NAFLD. Gene Ontology (GO) and KEGG pathway enrichment analyses have identified potential biochemical and signaling pathways. Subsequently, the potential mechanism of action of LAH on NAFLD predicted by network pharmacology analysis was validated in a high-fat diet (HFD)-induced NAFLD model in C57BL/6 mice. Our results demonstrated that LAH ameliorated hepatocyte steatosis in liver tissue by activating the AMPK pathway and decreasing serum triglycerides, low-density lipoprotein, glucose, and cholesterol. Besides, LAH increased the hepatic antioxidant enzymes activities, suggested that LAH improved oxidative stress markers in HFD induced NAFLD mice. In vitro experiments confirmed that the active component of LAH, puerarin, regulates lipid accumulation through the AMPK pathway. In conclusion, our study shows that network pharmacology predictions are consistent with experimental validation. LAH can be a candidate supplement for the prevention of NAFLD.
European national health plans and the monitoring of online searches for information on diabetes mellitus in different European healthcare systems
Authors: Bosch-Frigola Irene , Coca-Villalba Fernando , Pérez-Lacasta María José , Carles-Lavila Misericòrdia
Published: November 2022

Diabetes mellitus (DM) is a serious non-communicable disease (NCD) and relies on the patient being aware of their condition, proactive, and having adequate medical care. European countries healthcare models are aware of the impact of these variables. This study evaluates the impact of online health information seeking behavior (OHISB) during World Diabetes Mellitus Day (WDMD) in European countries from 2014 to 2019 by grouping countries according to the changes in citizens' search behavior, diabetes mellitus prevalence, the existence of National Health Plans (NHP), and their respective healthcare systems. We extracted data from Global Burden of Disease, Google Trends (GT), Public Health European Commission, European Coalition for Diabetes, and the Spanish Ministry of Health. First, we used the broken-line models to analyze significant changes in search trends (GT) in European Union member countries in the 30-day intervals before and after the WDMD (November 14) from 2014 to 2019. Then the results obtained were used in the second phase to group these countries by factor analysis of mixed data (FAMD) using the prevalence of DM, the existence of NHP, and health models in each country. The calculations were processed using R software (gtrendsR, segmented, Factoextra, and FactoMineR). We established changes in search trends before and after WDMD, highlighting unevenness among European countries. However, significant changes were mostly observed among countries with NHP. These changes in search trends, in addition to being significant, were reiterated over time and occurred especially in countries belonging to the Beveridge Model (Portugal, Spain, and Sweden) and with NHPs in place. Greater awareness of diabetes mellitus among the population and continuous improvements in NHP can improve the patients' quality of life, thus impacting in disease management and healthcare expenditure.
Racism in public health services: A research agenda
Authors: Namer Yudit , Wandschneider Lisa , Stieglitz Sigsten , Starke Dagmar , Razum Oliver
Published: November 2022

Despite racism and its impact on health inequities being increasingly studied in health care settings, racism in public health services has so far been neglected in public health research. Studying racism in public health services provides many opportunities to explore the relationship between racism and health protection. We identify several research themes to be explored on (1) non-stigmatizing and community-driven risk communication, (2) surveillance by public health authorities of racialized minority groups, (3) racism experiences in everyday interactions with public health authorities, (4) legal consequences of encounters with public health authorities and (5) public health infrastructure, structural racism and the intersectionality of marginalization. Tackling these research themes will help to start building an evidence base on how racism interferes with equitable health protection and how to dismantle it.
Comparison of clinical characteristics between COVID-19 and H7N9 fatal cases: An observational study
Authors: Jiang Hui , Liu Fangchao , Chan Ta-Chien , Yin Jinfeng , Huang Ruowen , Shen Li , Tu Shengjin , Kang Liang , Liu Wen , Zhao Na , Zhang Di , Xu Wangli , Li Weimin , Liu Shelan , Huang Chaolin
Published: November 2022

Objective

The outbreak of COVID-19 in 2020 is reminiscent of the H7N9 outbreak in 2013, which poses a huge threat to human health. We aim to compare clinical features and survival factors in fatal cases of COVID-19 and H7N9.

Methods

Data on confirmed COVID-19 and H7N9 fatal cases identified in mainland China were analyzed to compare demographic characteristics and clinical severity. Survival curves were estimated by the Kaplan–Meier method and compared using log-rank tests and a restricted mean survival time model. A Cox regression model was used to identify survival factors in fatal cases of COVID-19 and H7N9.

Results

Similar demographic characteristics were observed in fatal cases of COVID-19 and H7N9. The proportion of fatal cases of H7N9 receiving antibiotics, antiviral drugs, and oxygen treatment was higher than that of COVID-19. The potential protective factors for fatal COVID-19 cases were receiving antibiotics (HR: 0.37, 95% CI: 0.22–0.61), oxygen treatment (HR: 0.66, 95% CI: 0.44–0.99), and corticosteroids (HR: 0.46, 95% CI: 0.35–0.62). In contrast, antiviral drugs (HR: 0.21, 95% CI: 0.08–0.56) and corticosteroids (HR: 0.45, 95% CI: 0.29–0.69) were the protective factors for H7N9 fatal cases.

Conclusion

The proportion of males, those having one or more underlying medical condition, and older age was high in COVID-19 and H7N9 fatal cases. Offering antibiotics, oxygen treatment, and corticosteroids to COVID-19 cases extended the survival time. Continued global surveillance remains an essential component of pandemic preparedness.
Morphological characteristics and biological cycle of the hoverfly Eristalinus arvorum (Fabricius, 1787) (Diptera, Syrphidae)
Authors: Cao Liang , Zeng Qing , Ren Qiuxia , Zeng Aiping , Zhang Yongsheng
Published: November 2022

The hoverfly Eristalinus arvorum (Fabricius, 1787) (Diptera: Syrphidae), which belongs to the tribe Eristalini, is well known as a pollinating agent for crops and flowering plants in agricultural and natural ecosystems. Large quantity, wide distribution and their ecological function of the hoverfly E. arvorum make them an appropriate candidate for use as pollinators and environmental indicator species. However, little information has been known on the morphology and the biological cycle of the hoverfly. In this study, feeding experiments under artificial climate chamber and morphological qualitative and quantitative observations were carried out to study the morphology and the biological cycle of the hoverfly E. arvorum. The morphology of eggs, larvae, pupae, and adults of E. arvorum were described in detail for the first time. A complete generation of E. arvorum lasts about 30.12 ± 0.14 days, and there is no significant difference in body length between males (10.27 ± 0.29 mm) and females (11.16 ± 0.45 mm). The most noteworthy morphological features of E. arvorum are the stripes on the compound eyes, the mesonotum, and the abdomen of adults, the chorionic structure consisting of fusiform units on the egg's surface, and the anterior spiracles and pupal spiracles of the pupae. Thus, the detailed description based on morphology and life history will provide the basis for the identification, biodiversity conservation and artificial breeding of the hoverfly E. arvorum.
Epistemologia e política em Helvétius
Authors:   , Nascimento José Cláudio do
Published: November 2022

A presente dissertação tem como objetivo apresentar e analisar as teses do filósofo ClaudeAdrien Helvétius (1715-1775), sob um enfoque epistemológico. Sua teoria filosófica se insere no contexto do movimento iluminista francês do século XVIII. Insere-se também na tradição da teoria do conhecimento do empirismo inglês do século anterior. De acordo com essa escola filosófica, os conhecimentos humanos têm sua origem nas sensações ou experiências dos cinco sentidos, não existindo ideias inatas – que de acordo com a escola racionalista fundamentam todo conhecimento humano. A teoria de Helvétius se insere também no movimento denominado materialismo, embora o filósofo não se assuma explicitamente como tal. Com argumentos e desenvolvimentos próprios, ela adere àquele pressuposto colocado em evidência pelo filósofo Julien Offray de la Mettrie (1709-1751), segundo o qual os conteúdos mentais, como as ideias e sentimentos, são um efeito da matéria. A teoria de Helvétius demonstra o modo como a vida mental do homem se origina das sensações e de como a organização peculiar do homem, que ele denomina de sensibilidade física, determina as capacidades e faculdades humanas. Essa sensibilidade é inteiramente material, pois se distingue unicamente por sua peculiar organização, que no homem adquire uma complexidade que está fora do escopo da filosofia investigar, sendo, pois, atinente às ciências empíricas. O filósofo se utiliza do método da redução para demonstrar que as ideias e sentimentos podem ser reduzidos às sensações físicas e que o prazer e a dor fundamentam todo o comportamento. A ética e epistemologia, nesse sentido, podem ser explicadas a partir dos princípios que determinam a conduta humana.
Propriedades ópticas dos vidros BBZP dopados com Nd e Ag
Authors:   , Silva Anna Luisa Aguiar
Published: November 2022

O estudo de vidros de óxidos dopados com o terra-rara Nd3+ e com nanopartículas de Ag possui grande interesse tecnológico por conta da sua utilização em lasers no infravermelho, dispositivos de armazenamento óptico de alta densidade, etc. O impacto das nanopartículas de prata nos atributos de emissão de Nd3+ quando elas estão presentes na co-dopagem da matriz de vidro borato cuja estrutura é B2O3-Bi2O3-ZnO-P2O5 (BBZP) é o foco do presente trabalho. A tentativa de nucleação e crescimento de nanopartículas de prata em decorrência de tratamento térmico realizado nas amostras a 500°C foi estudada e discutida. Observou-se a diminuição na absorção e na emissão das amostras dopadas com Nd e Ag em comparação com as amostras que foram dopadas somente com Ag, através das medidas de absorção feitas no ultravioleta-visível, no infravermelho próximo (NIR) e das medidas de fotoluminescência. Estudou-se também as alterações estruturais da matriz vítrea por meio das técnicas de espectroscopia Raman e absorção no infravermelho médio (MIR) e de comparações com resultados previamente obtidos na literatura. Foram feitas análises de tempo de vida de decaimento radiativo das amostras através da técnica de fotoluminescência resolvida no tempo que nos forneceu resultados de 0,16 ms para a transição do neodímio em 1060 nm. Em termos gerais a matriz de BBZP co-dopada com Nd e Ag não aumentou a emissão do neodímio que era o resultado esperado. No entanto, observamos uma emissão intensa em 1040 e 1084 nm quando a matriz dopada com prata foi bombeada com laser de 325 nm. Este aumento de emissão também foi verificado nas amostras co-dopadas com neodímio no que se refere a emissão de 1084 nm.
Estudo duplo cego randomizado com suplementação com isolado de proteínas do soro para profilaxia da mucosite oral no transplante de células tronco hematopoéticas
Authors:   , Perrone Ana Carolina Amaral de São José
Published: November 2022

Os pacientes em regime de condicionamento para o transplante de células tronco hematopoéticas (TCTH) apresentam elevada incidência das formas mais graves da mucosite oral. O isolado de proteínas do soro (IPS) é composto por uma série de fatores de crescimento celular, dentre eles os fatores de crescimento transformador beta que compreende uma família de peptídeos e contribuem para o reparo tecidual. A partir da hipótese de que a suplementação alimentar com IPS teria o potencial de reduzir a mucosite oral, desenvolvemos um estudo clínico randomizado com pacientes submetidos ao TCTH autólogo e alogênico no Hospital Universitário da Universidade Federal de Juiz de Fora, com diferentes protocolos de condicionamento. Os pacientes foram suplementados com uma dose diária de IPS contendo 50% das necessidades diárias de proteína conforme Dietary Reference Intakes e classificados, posteriormente, quanto a quantidade de suplemento ingerida. Os critérios do National Cancer Institute, versão 4.0, foram utilizados para a classificação dos eventos adversos ocorridos e para avaliação da mucosite oral, a partir da escala de toxicidade oral da Organização Mundial da Saúde. Um total de 40 pacientes submetidos ao transplante de células tronco hematopoéticas foram avaliados. Destes, 20 fizeram parte do grupo controle e 20 do grupo intervenção, os quais receberam IPS. A mucosite oral (MO) teve duração média de 7,52 dias (DP: 2,73), variando entre 4 a 14 dias. A média de início variou entre o 2º dia antes da infusão de células tronco até o 7º dia após infusão e mediana no 5º dia após infusão. A incidência de MO no grupo intervenção foi 40% e no grupo controle 65% (OR= 2,7857, IC= 2,3638 – 3,1962). A mucosite grave esteve presente em 10% dos pacientes do grupo intervenção e 30% dos pacientes do grupo controle (OR= 3,8571, IC= 3,4409 – 4,2734). Observou-se uma menor queda do fator de crescimento transformador beta (TGF-β) plasmático no grupo intervenção, a média foi de 452,81ng/mL (DP: 391,25) no início da neutropenia, enquanto no grupo controle foi de 172,90ng/mL (DP:110,68) (p=0,022). Estudos adicionais são necessários para contribuir com os atuais achados e ampliar as possibilidades de prevenção desta toxicidade.
Platform for integrated monitoring data management applied to an instrumented slope in southern Brazil
Authors: Salah Isabel Cristina , Silva Milena Arruda , Acevedo Andres Miguel Gonzalez , Sestrem Liamara Paglia , Faro Vitor Pereira
Published: November 2022

The monitoring of slopes and geotechnical structures is fundamental for guaranteeing safety and improving the knowledge of soil behavior. This study evaluated the use of a platform for integrated monitoring data management applied to an instrumented slope. The slope, known as “Morro do Boi”, is located in BR-101 highway, in Santa Catarina state, Brazil. The instrumentation was installed in 2012 during the execution of a stabilization system designed to contain an unstable soil mass, and allows the verification of positive and negative pore pressure, deformations of the soil mass and the precipitation. In addition, the structure, composed by passive anchors and flexible metal mesh, is monitored with crackmeters, strain gages and load cells. Until May 2018, the historical data comprising 6 years of monitoring was automatically registered by a datalogger hourly, with manual download. On June 2018, the remote dispatch of the data was implemented and the management of this information is done through a web-based platform. This tool has been extremely useful for the ease of visualization, data management and logistical efficiency, allowing the creation of a rapid alert system in cases of variation of some parameters that could trigger landslide.
Fratura de colo de fêmur na infância: um relato de caso
Authors: Reckers Leandro José , Araújo Rafael Leandro , Dias Sandro de Mattos , Ribeiro Cristina Dutra , Godinho Gabriella Mangucci , Echeverria Murilo Silveira , Borges Olívia Abrantes
Published: November 2022

Fraturas de colo de fêmur em crianças são traumas raros geralmente decorrentes de impactos de alta energia associados a situações de politrauma, demandando intervenção cirúrgica de forma urgente. Traumas nesta região podem comprometer a vascularização da cabeça do fêmur, podendo culminar na necrose da mesma. O presente relato de caso traz a história detalhada, exame e tratamento de um menino de 9 anos de idade, com uma fratura de colo de fêmur desencadeada por um mecanismo de valgo da coxa, ao praticar futebol. O paciente foi intervido em menos de 12 horas após o trauma.
Métodos de previsão de demanda de materiais: aplicação em uma empresa de administração pública
Authors: Almeida Rafael Ferreira , Amaral Tatiana Gondim do , Silva Paulo Afonso Lopes da
Published: November 2022

O objetivo deste artigo é identificar qual método de análise de séries temporais tem menor erro de previsão, para gerar estimativas futuras mais assertivas. Na empresa em foco, as atividades relacionadas ao planejamento da demanda são realizadas na gestão de materiais, e a importância do estudo da previsão de demanda nesse contexto é melhorar o nível de suprimento de insumos aos reparos navais. A metodologia empregada foi, primeiro, analisar a eficiência do método de previsão utilizado, por meio do indicador de nível de serviço dos pedidos atendidos em relação aos solicitados. Após se realizou uma classificação abc para priorização dos materiais que terão maior atenção no planejamento da demanda, porque os recursos são limitados. Identificaram-se 34 itens (10,93% do total) que representava 79,90% do valor de consumo dos últimos 12 períodos e, ao analisar o comportamento da série histórica de consumo do principal item classe a, através do sistema de informações gerenciais, propôs-se a aplicação de métodos de análise de séries temporais de modelo fixo, como a média simples (método atual aplicado pela empresa), média móvel simples, média móvel ponderada e amortecimento exponencial. Como resultados, reduziu-se o capital imobilizado, evitou-se a ruptura do estoque e garantiu-se a operacionalidade da organização.
As histórias em quadrinhos e sua articulação com os projetos integradores no ensino de ciências
Authors: Cardoso Hellen Luyza Fernandes , Oliveira Irlane Maia de
Published: November 2022

Este trabalho apresenta uma análise bibliográfica e documental a respeito do potencial das histórias em quadrinhos (HQ’s) como ferramenta articulada aos projetos integradores no Ensino de Ciências. Destaca-se como objetivo analisar 3 trabalhos que favorecem a aplicação dessa ferramenta, em sua maioria no Ensino de Ciências, e os documentos norteadores, principalmente dos projetos integradores ligados ao Programa Nacional do Livro didático (PNLD). Os projetos integradores são livros de apoio ao livro didático. Trata-se de projetos prontos alinhados à BNCC, com temáticas para a sociedade e que buscam uma abordagem com a pedagogia de projetos centrada no estudante. Com isso, estimula-se a atitude ativa em relação ao contexto social, à criatividade, propõe-se a solução de problemáticas, o desenvolvimento de conhecimento e habilidades. É notório que, no contexto escolar, em especial nos anos finais, há dificuldades específicas por parte dos estudantes, no que diz respeito à leitura, à interpretação e até à solução de problemáticas. Esse cenário torna-se mais evidente no componente curricular “Ciências e Língua Portuguesa”. De acordo com os dados do PISA 2019, o Brasil encontra-se, no componente curricular ciências, entre o 72ºe o 74º lugar, e entre o 66º e o 68º na leitura, resultados divulgados pelo Ministério da Educação, o que demonstra dificuldades específicas no processo de ensino-aprendizagem. Nesse sentido, vemos a relevância de analisar o potencial das Histórias em Quadrinhos articuladas aos projetos integradores no componente curricular “Ciências”. A metodologia iniciou-se com a busca na “Biblioteca de Teses e Dissertações” e elementos de análise documental em especial do projeto integrador “Da escola para o Mundo 8ºe 9º anos”. Como resultado, a partir da análise bibliográfica, nota-se a variação de assuntos por meio das HQ’s. Não foram encontrados trabalhos voltados para projetos integradores. Ao analisar o projeto integrador, nota-se que, ao se propor trabalhos com esse viés é possível ensinar de maneira inter e transdisciplinar com ênfase no tratamento de conteúdos, saberes e habilidades.
Endometriose: fisiopatologia e manejo terapêutico
Authors: Moreira Mariana Luiza , Vitório Luize Lucas Miranda Ribeiro , Mazzarollo Ana Vitória Scherner , Schiezari Beatriz Angarani , Souza Júlia Rosa de , Santos Carla Rodrigues dos , Carvalho Natalha Cristina de , Vilaça Rafael Saldanha
Published: November 2022

A endometriose é definida como a presença anormal de tecido endometrial fora da cavidade uterina, manifestando-se como uma condição inflamatória crônica, benigna, estrogênio-dependente e grande causadora de dor e infertilidade. Essa afecção atinge cerca de 10% das mulheres em idade reprodutiva e afeta mais de 170 milhões de mulheres no mundo, apresentando seu pico de incidência entre 25 e 45 anos de idade e a sua prevalência aumenta em mulheres com dismenorreia, infertilidade e/ou dor pélvica. Os mecanismos dessa condição não são completamente conhecidos, mas entre eles, coexistem fatores etiológicos, congênitos, ambientais, genéticos, autoimunes, imunológicos e endócrinos. A sintomatologia da endometriose é diversa, porém, destaca-se dor pélvica crônica, dismenorreia e infertilidade. A anamnese e o exame físico dessa patologia revelam queixa principal de dor, em suas mais variadas durações, formas e localidades, sendo primariamente citadas dor pélvica cíclica, dismenorreia, dor periovulatória, dor pélvica crônica não cíclica, dispareunia posicional ou permanente, disquezia e disúria. Os fatores genéticos mais comuns relacionados ao risco de endometriose estão localizados em sequências reguladoras de DNA, que acabam por alterar a regulação da transcrição gênica. A ultrassonografia transvaginal é um exame básico no diagnóstico da endometriose, sendo uma ferramenta investigativa e técnica de imagem de primeira linha em pacientes com suspeita de tal afecção. A tomografia computadorizada não detém papel na avaliação de rotina da endometriose, exceto em poucos e particulares cenários. A laparoscopia com confirmação simultânea no exame histopatológico é o padrão ouro para o diagnóstico. As terapêuticas possíveis são o controle de sintomas, melhora da qualidade de vida das pacientes, manutenção da fertilidade, redução da recorrência e das abordagens cirúrgicas. A abordagem cirúrgica, ainda que não seja a indicação primária, tem extrema valia e o método usado varia conforme a clínica do paciente, sendo a videolaparoscopia o método preferencial de tratamento.
Líquen escleroso atrófico vaginal e a importância do exame físico: um relato de caso
Authors: Parrode Natalia Fukuciro , Mendes Thays de Oliveira Rocha , Sousa Iasmine Saad , De Assis Caroline Borges , Cardoso Mariana Cabral de Oliveira , Ferreira Rafaela Martins , Pereira Milena Batistela , Ribeiro Júnior Nelson Camilo
Published: November 2022

O líquen escleroso e atrófico (LEA) é uma dermatose inflamatória de caráter benigno, que acomete principalmente mulheres e acontece nos extremos de faixa etária, isto é, na pré-menarca e na pós-menopausa. É uma doença relativamente incomum e, por isso, de aparecimento raro na atenção primária à saúde (APS). Por seus sinais e sintomas, é frequentemente confundida com dermatoses infecciosas, principalmente a candidíase vulvovaginal. Uma propedêutica adequada, com anamnese e exame físico completos, e, principalmente, um exame ginecológico feito com atenção e cuidado, podem ser determinantes do diagnóstico precoce da doença e da instituição de um tratamento adequado. O exame ginecológico, no entanto, é muitas vezes negligenciado, sobretudo quando há fortes indícios epidemiológicos em favor de doenças mais comuns, ou quando o médico da APS, por vários motivos, não se sente seguro na sua realização, o que pode levar à demora diagnóstica, à tratamentos incorretos e ineficazes e ao descrédito da paciente em relação à atuação médica. O presente trabalho é o relato de caso de uma paciente de 72 anos que buscou atendimento na APS para renovação de receitas, mas, durante a entrevista clínica, apresentou queixa de um “caroço” na região vulvar de longa data - pelo menos dois anos - associado a intenso prurido e disúria, sem melhora ao uso de cremes vaginais tópicos com metronidazol e nistatina prescritos anteriormente, com diagnóstico prévio de “candidíase vulvovaginal”. Apresentou, no exame ginecológico - que disse nunca ter sido realizado desde o início da queixa, aspecto compatível com LEA e, após exclusão de malignidade, respondeu bem ao uso de corticosteroide tópico prolongado, com resolução do quadro.
Pengaruh Return on Invesment (ROI), Earning Per Share (EPS), dan Price Earning Ratio (PER) Terhadap Harga Saham pada Perusahaan Sektor Infrastruktur
Authors: Alex Muhd , Elfiswandi  , Zefriyenni
Published: November 2022

Penelitian ini dilatar belakangi oleh adanya perkembangan harga saham pada perusahaan Sektor Infrastruktur, Utilitas Dan Transportasi. Penelitian ini bertujuan untuk mengetahui pergerakan Harga Saham dari tahun ketahun dengan Kebijakan Dividen sebagai variabel intervening pada perusahaan Sektor Infrastruktur, Utilitas Dan Transportasi yang terdaftar di bursa efek indonesia 2017-2021. Sampel pada penelitian ini diambil dengan menggunakan teknik purposive sampling dengan jumlah sampel sebanyak 37 perusahaan Sektor Infrastruktur, Utilitas Dan Transportasi yang terdaftar di BEI sejak 2017-2021. Metode analisis dari penelitian ini menggunakan metode analisis regresi linier berganda. Pada penelitian ini, bertujuan untuk mengetahui pengaruh Return On Invesment (ROI), Earning Per Share (EPS) dan Price Earning Ratio (PER) terhadap pergerakan harga saham dengan Kebijakan Dividen sebagai variabel intervening pada Perusahaan Sektor Infrastruktur, Utilitas Dan Transportasi yang terdaftar di bursa efek indonesia 2017-2021. Hasil penelitian ini menunjukkan bahwa secara parsial Return On Infesment (ROI) berpengaruh signifikan terhadap kebijakan Dividen, sedangkan Earning per Share (EPS) dan Price Earning Ratio (PER) tidak berpengaruh signifikan terhadap kebijakan Dividen, Return On Infesment (ROI) tidak berpengaruh signifikan terhadap Harga Saham, sedangkan Earning per Share (EPS) dan Price Earning Ratio (PER)  berpengaruh signifikan  terhadap  Terhadap Harga Saham, Kebiajakan Dividen berpengaruh signifikan  terhadap  Terhadap Harga Saham, Return On Infesment (ROI) dan Price Earning Ratio (PER)  tidak berpengaruh signifikan  terhadap  Terhadap Harga Saham melalui Kebijakan Dividen sebagai variabel intervening, sedangkan Earning per Share (EPS) berpengaruh signifikan  terhadap  Terhadap Harga Saham melalui Kebijakan Dividen sebagai variabel intervening pada Perusahaan Sektor Infrastruktur, Utilitas Dan Transportasi yang terdaftar di bursa efek indonesia 2017-2021
ANALISIS PENGARUH MANAJEMEN KUALITAS TOTAL TERHADAP KINERJA UKM DENGAN MEDIASI BUDAYA ORGANISASI PADA SEKTOR PAKAIAN MUSLIM DI TANAH ABANG, JAKARTA PUSAT
Authors: Saidah Saidah , Santosa Wahyuningsih , Haryanto Jennifer Victoria Astari
Published: November 2022

This study aims to examine and analyze of the effect of Total Quality Management on SME’s Performance by mediating of Organizational Culture in Muslim clothing sector in Tanah Abang, Central Jakarta. Data collection methods obtained by distributing questionnaire with a simple random sampling to 125 respondents. The analysis method is Partial Least Square- Structural Equation Modelling (PLS-SEM) using application SmartPLS 3.0. The result of this study showed that in first hypothesis there was a effect of Total Quality Management on SME’s Performance, then in second hypothesis there was a effect of Total Quality Management on Organizational Culture, then in third hypothesis there was a effect of Organizational Culture on SME’s Performance, and next in fourth hypothesis there was a effect of Total Quality Management on SME’s performance by mediating of Organizational Culture.

Keywords: Organization Culture, SME’s Performance, Total Quality Management
ANALISIS PENERAPAN CORPORATE SOCIAL RESPOSIBILITY (CSR) TERHADAP LABA BERSIH PERUSAHAAN PADA PT. SEMEN BATURAJA (PERSERO) Tbk PALEMBANG
Authors: Swari Riyani Tridina , Putra Andri Eko , Oktariansyah Oktariansyah
Published: November 2022

The purpose of this study is to determine the application of Corporate Social Responsibility (CSR) towards the company's net profit at PT. Semen Baturaja (Persero) Tbk Palembang. This research method is a qualitative method. The results of the analysis showed that PT. Semen Baturaja (Persero) Tbk Palembang had implemented the Corporate Social Resposibilty program from 2016 to 2020 that was quite good and in accordance with the direction of the Ministry of SOEs, the Corporate Social Resposibility (CSR) program at PT. Semen Baturaja (Persero) Tbk has been divided into several assistance sectors, namely natural disasters, education & training, health improvement, infrastructure, worship facilities and preservation. However, the company's net profit experienced a decline from 2016 to 2020.

Keywords : Corporate Social Resposibility (CSR), Net profit, Semen Baturaja
Sebuah Model Deteksi Fraud Berbasis Karakteristik Individu dan Lingkungan
Authors: Amal Muhammad Ihlashul , Asrori Asrori , Fachrurrozie Fachrurrozie , Wahyuningrum Indah Fajarini Sri , Afita Dea
Published: November 2022

Kecurangan dalam dunia bisnis pada akhirnya dapat berakibat pada penyusunan dan penyajian laporan keuangan yang menyesatkan. Kecurangan seharusnya dapat terdeteksi sebelum dikeluarkannya laporan auditor independen. Namun, tidak sedikit laporan keuangan yang memeroleh opini audit tanpa modifikasian terindikasi menyajikan pelaporan under-/ overstatement yang disengaja (fraud). Nampak bahwa auditor sebagai filter terakhir tidak mampu mendeteksi kecurangan sehingga perlu dilakukan audit khusus oleh Auditor lain. Melalui pengujian hipotesis, penelitian ini akan menganalisis hubungan antara “karakteristik individu” yang meliputi kompetensi dan independensi, “karakteristik lingkungan kerja auditor” yang meliputi beban kerja dan etika, dengan kemampuan auditor dalam mendeteksi kecurangan. Penelitian ini mengumpulkan data primer dengan menyebar kuesioner pada Kantor Akuntan Publik (KAP) di Kota Semarang. Jumlah responden dalam penelitian ini sebanyak 82. Demografi Responden didominasi oleh tingkat pendidikan S1. Hal ini yang menyebabkan tidak didukungnya hipotesis yang menyatakan variabel kompetensi berpengaruh positif terhadap kemampuan auditor dalam mendeteksi kecurangan, karena karakteristik responden yang homogen dilihat dari tingkat pendidikannya. Variabel independensi tidak berpengaruh terhadap kemampuan auditor dalam mendeteksi kecurangan dan variabel etika kerja bukan merupakan variabel moderasi karena tingkat signifikansi probabilitas dari koefisien interaksi variabel independen dengan variabel moderator tidak signfikan (>0.05). Hal yang menarik dalam penelitian ini adalah beban kerja berpengaruh positif terhadap variabel kompetensi terhadap variabel kompetensi auditor dalam mendeteksi kecurangan. Meskipun hipotesis tidak didukung, fenomena ini dapat dijelaskan dalam literatur perilaku organisasi bahwa hubungan beban kerja dengan kinerja tidak sepenuhnya berupa hubungan yang linear melainkan hubungan non linear. Pada titik nol sampai dengan titik tertentu (puncak) beban kerja dapat meningkatkan kinerja. Namun mulai pada titik tertentu/puncak tersebut beban kerja dapat menurunkan kinerja karyawan.
Villámárvíz elleni műszaki védekezés támogatása térinformatikai módszerekkel
Authors: Dobai András , Dobos Endre
Published: November 2022

A napjainkban megfigyelhető szélsőséges időjárási események közül az egyik legmarkánsabb a konvektív zónákban keletkező viharok által kiváltott villámárvizek jelensége, amely Magyarországon a hegy és dombvidéki területeket érinti. Jelen tanulmány a Borsod-Abaúj-Zemplén megyében található Harica-patak részvízgyűjtőit elemzi villámárvíz veszélyeztetettségi szempontból, továbbá alternatív védekezési módot kíván bemutatni a völgyekben levonuló árhullámokkal szemben. A módszertan egy 5m-es felbontású domborzatmodellt és az abból származtatott lejtőmeredekség és tájhasználati állományokat, valamint a Magyar Államkincstár által kárfelvételi jegyzőkönyvekben (ún. Vis maior jegyzőkönyvek) rögzített adatok adatbázisát dolgozza fel. A kutatás célja, hogy támogassa a védekezést irányítók szakmai tudását és segítse a vízügyben dolgozó építőmérnökök munkáját.