bluuebunny/crossref_metadata_2025 huggingface dataset:
Essential Oils from the Leaves, Stem, and Roots of Blumea lanceolaria (Roxb.) Druce in Vietnam: Determination of Chemical Composition, and In Vitro, In Vivo, and In Silico Studies on Anti-Inflammatory Activity
Authors: Do Thi Thanh Huyen , Nguyen Thi Uyen , Nguyen Thi Thu Huyen , Ho Thi Yen , Pham Thi Luong Hang , Le Tho Son , Nguyen Thi Hong Van , Nguyen Phi-Hung , Nguyen Quang Huy , Nguyen Van Sang
Published: November 2022

Blumea lanceolaria (Roxb.) Druce, a flowering plant, is used for treating cancer and inflammatory diseases. In this study, we determined the chemical composition of the EOs extracted from the leaves (LBEO), stem (SBEO), and roots (RBEO) of B. lanceolaria and analyzed their anti-inflammation potential. Overall, 30 compounds representing 99.12%, 98.44%, and 96.89% of total EO constituents of the leaves, stem, and roots, respectively, were identified using GC-MS. ELISA, Western blotting, and qRT-PCR studies showed that LBEO, SBEO, and RBEO inhibited multiple steps in the inflammatory responses in the RAW 264.7 cell model, including NO production; TNF-α, IL-6, iNOS, and COX-2 transcription and translation; and phosphorylation of IκBα and p65 of the NF-κB pathway. In the carrageenan-induced paw edema model, all three EOs inhibited paw edema at both early and delayed phases. Molecular docking studies indicated that the main components of B. lanceolaria EOs (BEOs) targeted and inhibited major components of inflammation-related pathways, including the arachidonic acid metabolic pathway, NF-κB pathway, and MAPK pathway. We present the first study to characterize the chemical composition of BEOs and confirm their potent anti-inflammatory effects in in vitro, in vivo, and in silico analysis. These results can facilitate the development of effective anti-inflammatory drugs with limited side effects in the future.
Facile Synthesis of Aminated Graphene Quantum Dots for Promising and Selective Detection of Cobalt and Copper Ions in Aqueous Media
Authors: Li Weitao , Jiang Ningjia , Zhang Luoman , Chen Yongqian , Gao Jie , Zhang Jihang , Yang Baoshuo , He Jianxin
Published: November 2022

Due to the rapid development of industrialization, various environmental problems such as water resource pollution are gradually emerging, among which heavy metal pollution is harmful to both human beings and the environment. As a result, there are many metal ion detection methods, among which fluorescence detection stands out because of its rapid, sensitive, low cost and non-toxic characteristics. In recent years, graphene quantum dots have been widely used and studied due to their excellent properties such as high stability, low toxicity and water solubility, and have a broad prospect in the field of metal ion detection. A novel high fluorescence Cu2+, Co2+ sensing probe produced by graphene quantum hydrothermal treatment is reported. After heat treatment with hydrazine hydrate, the small-molecule precursor nitronaphthalene synthesized by self-nitrification was transformed from blue fluorescent GQDs to green fluorescent amino-functionalized N–GQDs. Compared with other metal ions, N–GQDs are more sensitive to Cu2+ and Co2+ on the surface, and N–GQDs have much higher selectivity to Cu2+ and Co2+ than GQDs. The strategy proposed here is simple and economical in design.
Treatment of Water Contaminated with Non-Steroidal Anti-Inflammatory Drugs Using Peroxymonosulfate Activated by Calcined Melamine@magnetite Nanoparticles Encapsulated into a Polymeric Matrix
Authors: Darvishi Cheshmeh Soltani Reza , Asgari Fatemeh , Hassani Negin , Yoon Yeojoon , Khataee Alireza
Published: November 2022

In the present study, calcined melamine (CM) and magnetite nanoparticles (MNPs) were encapsulated in a calcium alginate (CA) matrix to effectively activate peroxymonosulfate (PMS) and generate free radical species for the degradation of ibuprofen (IBP) drug. According to the Langmuir isotherm model, the adsorption capacities of the as-prepared microcapsules and their components were insignificant. The CM/MNPs/CA/PMS process caused the maximum degradation of IBP (62.4%) in 30 min, with a synergy factor of 5.24. Increasing the PMS concentration from 1 to 2 mM improved the degradation efficiency from 62.4 to 68.0%, respectively, while an increase to 3 mM caused a negligible effect on the reactor effectiveness. The process performance was enhanced by ultrasound (77.6% in 30 min), UV irradiation (91.6% in 30 min), and electrochemical process (100% in 20 min). The roles of O•H and SO4•− in the decomposition of IBP by the CM/MNPs/CA/PMS process were 28.0 and 25.4%, respectively. No more than 8% reduction in the degradation efficiency of IBP was observed after four experimental runs, accompanied by negligible leachate of microcapsule components. The bio-assessment results showed a notable reduction in the bio-toxicity during the treatment process based on the specific oxygen uptake rate (SOUR).
Variable Dimensionality of Europium(III) and Terbium(III) Coordination Compounds with a Flexible Hexacarboxylate Ligand
Authors: Yu Xiaolin , Pavlov Dmitry I. , Ryadun Alexey A. , Potapov Andrei S. , Fedin Vladimir P.
Published: November 2022

A reaction between 4,4′,4″-(benzene-1,3,5-triyltris(oxy))triphthalic acid (H6L) and lanthanide(III) nitrates (Ln = Eu3+, Tb3+) in water under the same conditions gave a molecular coordination compound [Tb(H4.5L)2(H2O)5]∙6H2O in the case of terbium(III) and a one-dimensional linear coordination polymer {[Eu2(H3L)2(H2O)6]∙8H2O}n in the case of europium(III). The crystal structures of both compounds were established by single-crystal X-ray diffraction, and they were further characterized by powder X-ray diffraction, thermogravimetric analysis and infrared spectroscopy. The compounds demonstrated characteristic lanthanide-centered photoluminescence. The lanthanide-dependent dimensionality of the synthesized compounds, which are the first examples of the coordination compounds of hexacarboxylic acid H6L demonstrates its potential as a linker for new coordination polymers.
Enhanced Performance of Camphorsulfonic Acid-Doped Perovskite Solar Cells
Authors: Wincukiewicz Adam , Wierzyńska Ewelina , Bohdan Aliaksei , Tokarczyk Mateusz , Korona Krzysztof P. , Skompska Magdalena , Kamińska Maria
Published: November 2022

High-quality perovskite film with large grains and therefore reduced grain boundaries plays a significant role in improving the power conversion efficiency (PCE) and ensuring good long-term stability of the perovskite solar cells. In this work, we found that adding camphorsulfonic acid (CSA), a Lewis base, to the perovskite solution results in the crystallization of larger perovskite grains. By varying the concentration of CSA, we found that the optimal concentration of the additive is 1 mg/mL, which leads to an 20% increase in PCE of the cells compared to the reference CSA-free cell. Interestingly, we observed that the PCE of cells with an excess of CSA was initially poor, but may increase significantly over time, possibly due to CSA migration to the hole-transporting layer, leading to an improvement in its conductivity.
Status Quo on Graphene Electrode Catalysts for Improved Oxygen Reduction and Evolution Reactions in Li-Air Batteries
Authors: Gollavelli Ganesh , Gedda Gangaraju , Mohan Raja , Ling Yong-Chien
Published: November 2022

Reduced global warming is the goal of carbon neutrality. Therefore, batteries are considered to be the best alternatives to current fossil fuels and an icon of the emerging energy industry. Voltaic cells are one of the power sources more frequently employed than photovoltaic cells in vehicles, consumer electronics, energy storage systems, and medical equipment. The most adaptable voltaic cells are lithium-ion batteries, which have the potential to meet the eagerly anticipated demands of the power sector. Working to increase their power generating and storage capability is therefore a challenging area of scientific focus. Apart from typical Li-ion batteries, Li-Air (Li-O2) batteries are expected to produce high theoretical power densities (3505 W h kg−1), which are ten times greater than that of Li-ion batteries (387 W h kg−1). On the other hand, there are many challenges to reaching their maximum power capacity. Due to the oxygen reduction reaction (ORR) and oxygen evolution reaction (OES), the cathode usually faces many problems. Designing robust structured catalytic electrode materials and optimizing the electrolytes to improve their ability is highly challenging. Graphene is a 2D material with a stable hexagonal carbon network with high surface area, electrical, thermal conductivity, and flexibility with excellent chemical stability that could be a robust electrode material for Li-O2 batteries. In this review, we covered graphene-based Li-O2 batteries along with their existing problems and updated advantages, with conclusions and future perspectives.
Bioactivities and Microbial Quality of Lycium Fruits (Goji) Extracts Derived by Various Solvents and Green Extraction Methods
Authors: Rajkowska Katarzyna , Simińska Dorota , Kunicka-Styczyńska Alina
Published: November 2022

Goji berries, known for their health-promoting properties, are increasingly consumed around the world, often in the form of naturally- or freeze-dried fruits, further unprocessed. The aim of the study was to obtain dried goji berries extracts, characterized by high bioactivity and safety in terms of microbial contamination for the consumer. In the study, various solvents (water, ethanol, acetone, ethyl lactate, sunflower oil) and green extraction methods (heating and ultrasound-assisted extraction (UAE)) were used. In goji extracts, antioxidant activity and carotenoids content as bioactivity indicators, as well as total number of microorganisms were determined. Boiling of powdered dried goji fruits in water resulted in extracts with the best features, i.e., with high antioxidant properties (2.75–4.06 μmol of Trolox equivalent (TE)/mL), moderate to high content of carotenoids (0.67–1.86 mg/mL), and a reduced number of microorganisms compared with fruits. Extracts in 50% ethanol and 50% acetone were characterized primarily by very high antioxidant activity (3.09–4.90 μmol TE/mL). The high content of carotenoids (0.98–3.79 mg/mL) and high microbial quality (<10 CFU/g) were obtained by extraction in ethyl lactate by the UAE method. The results could be useful in the development of functional food based on goji berry ingredients.
Therapeutic Potential of 2-Methylquinazolin-4(3H)-one as an Antiviral Agent against Influenza A Virus-Induced Acute Lung Injury in Mice
Authors: Tian Rong , Zhu Haiyan , Lu Yan , Shi Xunlong , Tu Peng , Li Hong , Huang Hai , Chen Daofeng
Published: November 2022

Qingdai-Mabo (QM), a traditional Chinese herbal formula composed of medicinal herb and fungus, has been used for treatment of cough and viral pneumonia. However, the underlying mechanism and bioactive components against anti-influenza A virus remain unclear. In the present study, ethyl acetate (EA) extract of QM decoctions was tested for its biological activity against acute lung injury (ALI) and its main components were identified using UPLC−MS/MS. In total, 18 bioactive components were identified, including 2-Methylquinaozlin-4(3H)-one (C1), which showed significant antiviral activity in vitro with an IC50 of 23.8 μg/mL. Furthermore, we validated the efficacy of C1 in ameliorating ALI lesions and inflammation in influenza A virus-infected mice. The results showed that C1 significantly reduced the lung index, downregulated neuraminidase (NA) and nucleoprotein (NP), and decreased the expression of pro-inflammatory molecules IFN-α, TNF-α, MCP-1, IL-6, and IL-8; however, they enhanced levels of IL-10 and IFN-γ in lung homogenate from mice infected by influenza A virus. In addition, C1 inhibited the recruitment of macrophages. These in vitro and in vivo studies suggested that the significant anti-influenza A virus activity contributed to its curative effect on lesions and inflammation of viral pneumonia in mice. Given its potential antiviral activity against influenza A virus, C1 is determined to be a main active component in the EA extract of QM. Taken together, the antiviral activity of C1 suggests its potential as an effective treatment against viral pneumonia via the inhibition of virus replication, but the mechanism C1 on antiviral research needs to be explored further.
The Influence of NH4NO3 and NH4ClO4 on Porous Structure Development of Activated Carbons Produced from Furfuryl Alcohol
Authors: Kałamaga Agnieszka , Román-Martínez Maria Carmen , Lillo-Ródenas Maria Angeles , Wróbel Rafał Jan
Published: November 2022

The influence of NH4NO3 and NH4ClO4 on the porous texture and structure development of activated carbons produced from a non-porous polymeric precursor synthesized from furfuryl alcohol has been studied. The non-doped counterparts were prepared and studied for comparison purposes. NH4NO3 and NH4ClO4-doped polymers were carbonized under N2 atmosphere at 600 °C, followed by CO2 activation at 1000 °C and the obtained carbon materials and activated carbons were thoroughly characterized. The porosity characterization data have shown that NH4NO3-derived ACs present the highest specific surface area (up to 1523 m2/g in the experimental conditions studied), and the resulting porosity distributions are strongly dependent on the activation conditions. Thus, 1 h activation is optimum for the microporosity development, whereas larger activation times lead to micropores enlargement and conversion into mesopores. The type of doping salts used also has a substantial impact on the surface chemical composition, i.e., C=O groups. Moreover, NH4NO3 and NH4ClO4 constitute good sources of nitrogen. The type and contribution of nitrogen species are dependent on the preparation conditions. Quaternary nitrogen only appears in doped samples prepared by carbonization and pyrrolic, pyrydinic, and nitrogen oxide groups appear in the NH4NO3 -series. NH4NO3 incorporation has led to optimized materials towards CO2 and C2H4 sorption with just 1 h activation time.
A Comprehensive Study of N-Butyl-1H-Benzimidazole
Authors: Kazachenko Aleksandr S. , Tanış Emine , Akman Feride , Medimagh Mouna , Issaoui Noureddine , Al-Dossary Omar , Bousiakou Leda G. , Kazachenko Anna S. , Zimonin Dmitry , Skripnikov Andrey M.
Published: November 2022

Imidazole derivatives have found wide application in organic and medicinal chemistry. In particular, benzimidazoles have proven biological activity as antiviral, antimicrobial, and antitumor agents. In this work, we experimentally and theoretically investigated N-Butyl-1H-benzimidazole. It has been shown that the presence of a butyl substituent in the N position does not significantly affect the conjugation and structural organization of benzimidazole. The optimized molecular parameters were performed by the DFT/B3LYP method with 6-311++G(d,p) basis set. This level of theory shows excellent concurrence with the experimental data. The non-covalent interactions that existed within our compound N-Butyl-1H-benzimidazole were also analyzed by the AIM, RDG, ELF, and LOL topological methods. The color shades of the ELF and LOL maps confirm the presence of bonding and non-bonding electrons in N-Butyl-1H-benzimidazole. From DFT calculations, various methods such as molecular electrostatic potential (MEP), Fukui functions, Mulliken atomic charges, and frontier molecular orbital (HOMO-LUMO) were characterized. Furthermore, UV-Vis absorption and natural bond orbital (NBO) analysis were calculated. It is shown that the experimental and theoretical spectra of N-Butyl-1H-benzimidazole have a peak at 248 nm; in addition, the experimental spectrum has a peak near 295 nm. The NBO method shows that the delocalization of the aσ-electron from σ (C1–C2) is distributed into antibonding σ* (C1–C6), σ* (C1–N26), and σ* (C6–H11), which leads to stabilization energies of 4.63, 0.86, and 2.42 KJ/mol, respectively. Spectroscopic investigations of N-Butyl-1H-benzimidazole were carried out experimentally and theoretically to find FTIR vibrational spectra.
Ginsenoside Rh2 Induces HeLa Apoptosis through Upregulating Endoplasmic Reticulum Stress-Related and Downstream Apoptotic Gene Expression
Authors: Liu Ying , Wang Xinran , Qiao Juhui , Wang Jiawen , Jiang Leilei , Wang Chenxi , Yu Shiting , Zhang Peiguang , Zhao Daqing , Fan Meiling , Liu Meichen
Published: November 2022

Cervical cancer is a common gynecological malignancy afflicting women all over the world. Ginsenoside Rh2 (GRh2), especially 20(S)-GRh2, is a biologically active component in the natural plant ginseng, which can exhibit anticancer effects. Here, we aimed to investigate the effect of 20(S)-GRh2 on cervical cancer and elucidate the underlying mechanism through RNA-seq. In this study, the CCK-8 assay showed that 20(S)-GRh2 inhibited HeLa cell viability in a time- and dose-dependent manner. Caspase 3 activity and Annexin V staining results showed that 20(S)-GRh2 induced apoptosis of HeLa cells. Gene function enrichment analysis revealed that the biological process gene ontology (GO) terms were associated with the apoptotic signaling pathway. Biological process GO terms’ similarity network indicated that apoptosis might be from endoplasmic reticulum stress (ERs). Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that 20(S)-GRh2 primarily modulates apoptosis pathway genes. Combined protein–protein interaction network, hub gene screening, and qPCR validation data showed that ERs-related genes (ATF4 and DDIT3) and the downstream apoptotic genes (JUN, FOS, BBC3, and PMAIP1) were potential novel targets of 20(S)-GRh2-inducing cervical cancer cell apoptosis. Differential transcript usage analysis indicated that DDIT3 is also a differential transcript and its usage of the isoform (ENST00000552740.5) was reduced by 20(S)-GRh2. Molecular docking suggested that 20(S)-GRh2 binds to the targets (ATF4, DDIT3, JUN, FOS, BBC3, and PMAIP1) with high affinity. In conclusion, our findings indicated that 20(S)-GRh2 might promote ERs-related apoptosis of cervical cancer cells by regulating the DDIT3-based targets’ signal pathway. The role of 20(S)-GRh2 at the transcriptome level provides novel targets and evidence for the treatment of cervical cancer.
Activation of a Sweet Taste Receptor by Oleanane-Type Glycosides from Wisteria sinensis
Authors: Hobloss Samir , Bruguière Antoine , Pertuit David , Miyamoto Tomofumi , Tanaka Chiaki , Belloir Christine , Lacaille-Dubois Marie-Aleth , Briand Loïc , Mitaine-Offer Anne-Claire
Published: November 2022

The phytochemical study of Wisteria sinensis (Sims) DC. (Fabaceae), commonly known as the Chinese Wisteria, led to the isolation of seven oleanane-type glycosides from an aqueous-ethanolic extract of the roots. Among the seven isolated saponins, two have never been reported before: 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl-22-O-acetylolean-12-ene-3β,16β,22β,30-tetrol, and 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucuronopyranosylwistariasapogenol A. Based on the close structures between the saponins from W. sinensis, and the glycyrrhizin from licorice, the stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated.
Research Progress of Polymers/Inorganic Nanocomposite Electrical Insulating Materials
Authors: Yu Guang , Cheng Yujia , Duan Zhuohua
Published: November 2022

With the rapid development of power, energy, electronic information, rail transit, and aerospace industries, nanocomposite electrical insulating materials have been begun to be widely used as new materials. Polymer/inorganic nanocomposite dielectric materials possess excellent physical and mechanical properties. In addition, numerous unique properties, such as electricity, thermal, sound, light, and magnetic properties are exhibited by these materials. First, the macroscopic quantum tunneling effect, small-size effect, surface effect, and quantum-size effect of nanoparticles are introduced. There are a few anomalous changes in the physical and chemical properties of the matrix, which are caused by these effects. Second, the interaction mechanism between the nanoparticles and polymer matrix is introduced. These include infiltration adsorption theory, chemical bonding, diffusion theory, electrostatic theory, mechanical connection theory, deformation layer theory, and physical adsorption theory. The mechanism of action of the interface on the dielectric properties of the composites is summarized. These are the interface trap effect, interface barrier effect, and homogenization field strength effect. In addition, different interfacial structure models were used to analyze the specific properties of nanocomposite dielectric materials. Finally, the research status of the dielectric properties of nanocomposite dielectric materials in the electrical insulation field is introduced.
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis
Authors: Zhou Wei , Fu Yang , Xu Jin-Song
Published: November 2022

One of the most common diseases affecting people and leading to high morbidity is kidney injury. The alleviation of inflammation and apoptosis is considered a potential therapeutic approach for kidney injury. Sophocarpine (SOP), a tetracyclic quinolizidine alkaloid, exhibits various beneficial biological properties. To investigate the effects of SOP on isoproterenol (ISO)-induced kidney injury, we randomly divided mice into four groups: Control, ISO, ISO+SOP (20 mg/kg) and ISO+SOP (40 mg/kg). SOP was administered intraperitoneally to the mice over two weeks, accompanied by intraperitoneal stimulation of ISO (10 mg/kg) for another four weeks. After the mice were sacrificed, several methods such as ELISA, staining (H&E, TUNEL, DHE and Masson) and Western blotting were applied to detect the corresponding indicators. The kidney injury serum biomarkers SCr and BUN increased after the ISO challenge, while this effect was reversed by treatment with SOP. Pathological changes induced by ISO were also reversed by treatment with SOP in the staining. The inflammatory cytokines IL-β, IL-6, TNF-α, MCP-1 and NLRP3 increased after the challenge with ISO, while they were decreased by treatment with SOP. The apoptotic proteins cleaved-caspase-3 and Bax increased, while Bcl-2 decreased, after the challenge with ISO, and these effects were reversed by treatment with SOP. The antioxidant proteins SOD-1 and SOD-2 decreased after being stimulated by ISO, while they increased after the treatment with SOP. The fibrotic proteins collagen I, collagen III, α-SMA, fibronectin, MMP-2 and MMP-9 increased after the challenge with ISO, while they decreased after the treatment with SOP. We further discovered that the TLR-4/NF-κB and TGF-β1/Smad3 signaling pathways were suppressed, while the Nrf2/HO-1 signaling pathway was activated. In summary, SOP could alleviate ISO-induced kidney injury by inhibiting inflammation, apoptosis, oxidative stress and fibrosis. The molecular mechanisms were suppression of the TLR-4/NF-κB and TGF-β1/Smad3 signaling pathways and activation of the Nrf2/HO-1 signaling pathway, indicating that SOP might serve as a novel therapeutic strategy for kidney injury.
Influence of Cocatalysts (Ni, Co, and Cu) and Synthesis Method on the Photocatalytic Activity of Exfoliated Graphitic Carbon Nitride for Hydrogen Production
Authors: Rana Adeem Ghaffar , Schwarze Michael , Tasbihi Minoo , Sala Xavier , García-Antón Jordi , Minceva Mirjana
Published: November 2022

Exfoliated graphitic carbon nitride (ex-g-CN) was synthesized and loaded with non-noble metals (Ni, Cu, and Co). The synthesized catalysts were tested for hydrogen production using a 300-W Xe lamp equipped with a 395 nm cutoff filter. A noncommercial double-walled quartz-glass reactor irradiated from the side was used with a 1 g/L catalyst in 20 mL of a 10 vol% triethanolamine aqueous solution. For preliminary screening, the metal-loaded ex-g-CN was synthesized using the incipient wetness impregnation method. The highest hydrogen production was observed on the Ni-loaded ex-g-CN, which was selected to assess the impact of the synthesis method on hydrogen production. Ni-loaded ex-g-CN was synthesized using different synthesis methods: incipient wetness impregnation, colloidal deposition, and precipitation deposition. The catalysts were characterized by X-ray powder diffraction, X-ray photoelectron spectroscopy, nitrogen adsorption using the Brunauer–Emmett–Teller method, and transmission electron microscopy. The Ni-loaded ex-g-CN synthesized using the colloidal method performed best with a hydrogen production rate of 43.6 µmol h−1 g−1. By contrast, the catalysts synthesized using the impregnation and precipitation methods were less active, with 28.2 and 10.1 µmol h−1 g−1, respectively. The hydrogen production performance of the suspended catalyst (440 µmol m−2 g−1) showed to be superior to that of the corresponding immobilized catalyst (236 µmol m−2 g−1).
Preparation and Adsorption Performance Study of Graphene Quantum Dots@ZIF-8 Composites for Highly Efficient Removal of Volatile Organic Compounds
Authors: Li Hao , Cheng Youliang , Li Jiaxian , Li Tiehu , Zhu Jia , Deng Weibin , Zhu Jiajia , He Delong
Published: November 2022

Based on the large specific surface area and excellent adsorption potential of graphene quantum dots (GQDs) and zeolitic imidazolate framework-8 (ZIF-8) materials, a GQDs@ZIF-8 composite was constructed to achieve optimal matching of the microstructure and to acquire efficient adsorption of volatile organic compounds (VOCs). GQDs and ZIF-8 were synthesized and then compounded by the solution co-deposition method to obtain GQDs@ZIF-8 composites. GQDs were uniformly decorated on the surface of the ZIF-8 metal-organic framework (MOF), effectively restraining the agglomeration, improving the thermal stability of ZIF-8 and forming abundant active sites. Thus, the VOC removal percentage and adsorption capacity of the GQDs@ZIF-8 composites were significantly improved. Toluene and ethyl acetate were chosen as simulated VOC pollutants to test the adsorption performance of the composites. The results showed that, after the addition of GQDs, the adsorption property of GQDs@ZIF-8 composites for toluene and ethyl acetate was obviously improved, with maximum adsorption capacities of 552.31 mg/g and 1408.59 mg/g, respectively, and maximum removal percentages of 80.25% and 93.78%, respectively, revealing extremely high adsorption performance. Compared with raw ZIF-8, the maximum adsorption capacities of the composites for toluene and ethyl acetate were increased by 53.82 mg/g and 104.56 mg/g, respectively. The kinetics and isotherm study revealed that the adsorption processes were in accordance with the pseudo-first-order kinetic model and the Freundlich isotherm model. The thermodynamic results indicated that the adsorption process of the GQDs@ZIF-8 composites was a spontaneous, endothermic and entropy increase process. This study provides a new way to explore MOF-based adsorption materials with high adsorption capacity which have broad application prospects in VOC removal fields.
Using Stable Isotope Analyses to Assess the Trophic Ecology of Scleractinian Corals
Authors: Lesser Michael P. , Slattery Marc , Macartney Keir J.
Published: November 2022

Studies on the trophic ecology of scleractinian corals often include stable isotope analyses of tissue and symbiont carbon and nitrogen. These approaches have provided critical insights into the trophic sources and sinks that are essential to understanding larger-scale carbon and nitrogen budgets on coral reefs. While stable isotopes have identified most shallow water (<30 m) corals as mixotrophic, with variable dependencies on autotrophic versus heterotrophic resources, corals in the mesophotic zone (~30–150 m) transition to heterotrophy with increasing depth because of decreased photosynthetic productivity. Recently, these interpretations of the stable isotope data to distinguish between autotrophy and heterotrophy have been criticized because they are confounded by increased nutrients, reverse translocation of photosynthate, and changes in irradiance that do not influence photosynthate translocation. Here we critically examine the studies that support these criticisms and show that they are contextually not relevant to interpreting the transition to heterotrophy in corals from shallow to mesophotic depths. Additionally, new data and a re-analysis of previously published data show that additional information (e.g., skeletal isotopic analysis) improves the interpretation of bulk stable isotope data in determining when a transition from primary dependence on autotrophy to heterotrophy occurs in scleractinian corals.
Preliminary Evaluation of the Application of Algae-Based Biostimulants on Almond
Authors: Oliveira Ivo , Afonso Sílvia , Pinto Luís , Vieira Sofia , Vilela Alice , Silva Ana Paula
Published: November 2022

To improve almond performance under water limitations, the use of algae-based biostimulants may become a useful tool to reduce drought stress. However, besides possible effects on plant behavior, changes in fruit characteristics must also be considered. In this work, a preliminary study on the effect of two levels of an Ascophyllum nodosum-based biostimulant in the chemical characteristics of fruits from rain-fed cv. Marinada almond trees was carried out. The use of the recommended manufacturer’s dosage resulted in a decreased content of soluble sugars and proteins when compared to the use of half the recommended dosage and the control assays (water only). Similarly, and although no significant differences were recorded, the content of bioactive compounds (ortho-diphenols, total phenolics, and flavonoids) tended to increase in non-treated trees. Finally, sensory analysis of treated and non-treated fruits did not record any changes in the perceived attributes, showing that no negative effects on consumers’ acceptance will be caused by the application of this product. Long-term studies are needed to further confirm these results, also aimed at the monitoring of leaf gas exchange and water status parameters of trees.
Incorporation of Organic Growth Additives to Enhance In Vitro Tissue Culture for Producing Genetically Stable Plants
Authors: Hamdeni Imtinene , Louhaichi Mounir , Slim Slim , Boulila Abdennacer , Bettaieb Taoufik
Published: November 2022

The growing demand for native planting material in ecological restoration and rehabilitation for agro-silvo-pastoral ecosystems has resulted in a major global industry in their sourcing, multiplication, and sale. Plant tissue culture is used for producing high-quality, disease-free, and true-to-type plants at a fast rate. Micropropagation can help to meet the increasing demand for planting material and afforestation programs. However, in vitro plant propagation is an expensive technique compared to conventional methods using suckers, seeds, and cuttings. Therefore, adopting measures to lower production costs without compromising plant quality is essential. This can be achieved by improving the culture media composition. Incorporating organic growth additives can stimulate tissue growth and increase the number of shoots, leaves, and roots in culture media. Organic growth supplementation speeds up the formation and development of cultures and yields vigorous plants. Plant regeneration from meristems (shoot tips and axillary buds) is a reliable way to produce true-to-type plants compared with callus and somatic embryogenesis regeneration, but in vitro culture environments can be mutagenic. Therefore, detecting somaclonal variations at an early stage of development is considered crucial in propagating plants. The genetic stability of in vitro regenerated plants needs to be ascertained by using DNA-based molecular markers. This review aims to provide up-to-date research progress on incorporating organic growth additives to enhance in vitro tissue culture protocols and to emphasize the importance of using PCR-based molecular markers such as RAPD, ISSR, SSR, and SCoT. The review was assessed based on the peer-reviewed works published in scientific databases including Science Direct, Scopus, Springer, JSTOR, onlinelibrary, and Google Scholar.
In Vitro Anti-Inflammatory Effects of Symplocos sumuntia Buch.-Ham. Ex D. Don Extract via Blockage of the NF-κB/JNK Signaling Pathways in LPS-Activated Microglial Cells
Authors: Lim Jae Sung , Bae Jaehoon , Lee Seoyoung , Lee Da Young , Yao Lulu , Cho Namki , Bach Tran The , Yun Narae , Park Su-Jin , Cho Young-Chang
Published: November 2022

Symplocos sumuntia Buch.-Ham. ex D. Don (S. sumuntia) is a traditional medicinal herb used in Asia to treat various pathologies, including cough, stomachache, tonsillitis, hypertension, and hyperlipidemia. Although the anti-inflammatory activity of S. sumuntia has been reported, little is known about its anti-inflammatory activity and molecular mechanisms in microglial cells. Therefore, we investigated the inhibitory effects of S. sumuntia methanol extract (SSME) on the inflammatory responses in lipopolysaccharide (LPS)-treated BV2 cells. The SSME significantly inhibited the LPS-stimulated inducible nitric oxide synthase and cyclooxygenase-2 expression, as well as the production of nitric oxide (NO), a proinflammatory mediator. The production of proinflammatory cytokines, including interleukin (IL)-6, tumor necrosis factor-α, and IL-1β, was suppressed by the SSME in the LPS-induced BV2 cells. The mechanism underlying the anti-inflammatory effects of SSME involves the suppression of the LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) such as JNK. Moreover, we showed that the LPS-stimulated nuclear translocation of the nuclear factor-κB (NF-κB)/p65 protein, followed by IκB degradation, was decreased by the SSME treatment. Collectively, these results showed that the SSME induced anti-inflammatory effects via the suppression of the MAPK signaling pathways, accompanied by changes in the NF-κB translocation into the nucleus. Therefore, SSME may be employed as a potential therapeutic candidate for various inflammatory diseases.
Impact of High Night Temperature on Yield and Pasting Properties of Flour in Early and Late-Maturing Wheat Genotypes
Authors: Parveen Shamima , Rudra Shalini Gaur , Singh Bhupinder , Anand Anjali
Published: November 2022

The inexorable process of climate change in terms of the rise in minimum (nighttime) temperature delineates its huge impact on crop plants. It can affect the yield and quality of various crops. We investigated the effect of high night temperature (HNT) (+2.3 °C over ambient) from booting to physiological maturity on the yield parameters, grain growth rate (GGR), starch content, composition, and flour rheological properties in early (HI 1544, HI 1563) and late-maturing (HD 2932) wheat genotypes. The change in yield under HNT was highly correlated with grain number per plant (r = 0.740 ***) and hundred-grain weight (r = 0.628 **), although the reduction in grain weight was not significantly different. This was also reflected as an insignificant change in starch content (except in HI 1544). Under HNT, late-sown genotypes (HI 1563 and HD 2932) maintained high GGR compared to the timely sown (HI 1544) genotype during the early period of grain growth (5 to 10 days after anthesis), which declined during the later phase of grain development. The increased rheological properties under HNT can be attributed to a significant reduction in the amylose to amylopectin (AMY/AMP) ratio in early-maturity genotypes (HI 1544 and HI 1563). The AMY/AMP ratio was positively correlated to flour rheological parameters (except setback from peak) under HNT. Our study reports the HNT-induced change in the amylose/amylopectin ratio in early maturing wheat genotypes, which determines the stability of flour starches for specific end-use products.
Effects of Basal Selenium Fertilizer Application on Agronomic Traits, Yield, Quality, and Se Content of Dryland Maize
Authors: Wang Le , Gao Fei , Zhang Liguang , Zhao Li , Deng Yan , Guo Hongxia , Qin Lixia , Wang Chuangyun
Published: November 2022

To explore the efficiency of selenium (Se) fertilizer application in dryland maize, we tested five Se fertilizer application treatments: 0 g ha−1 (Se0), 75 g ha−1 (Se1), 150 g ha−1 (Se2), 225 g ha−1 (Se3), and 300 g ha−1 (Se4). Compared with Se0, Se2 increased the leaf area, chlorophyll content, internode length, plant height, and ear height by 7.95%, 3.20%, 13.19%, 1.89%, and 7.98%, respectively. Se2 and Se3 significantly affected the stem internode diameter, cortex thickness, and cellulose content, which were positively correlated with lodging resistance. Compared with Se0, Se3 promoted the contents of soluble sugar, crude protein, crude fat, and starch in grains, which increased by 9.48%, 6.59%, 1.56%, and 4.82%, respectively. It implies that maize grain application of Se significantly improves their Se content. Se1 did not observably influence the growth of maize, and the promoting effect of Se4 on maize decreased. The lodging resistance of maize as analyzed by Pearson correlation analysis correlated with the application of Se fertilizer. It proved that higher yield, grain quality, grain Se content, and lodging resistance of stems were concerned with Se fertilizer application in the range of 150–225 g ha−1. The results provide useful information for Se fertilizer treatment in dryland maize.
Effects of Low-Level Organic Mercury Exposure on Oxidative Stress Profile
Authors: Tincu Radu Ciprian , Cobilinschi Cristian , Florea Iulia Alexandra , Cotae Ana-Maria , Băetu Alexandru Emil , Isac Sebastian , Ungureanu Raluca , Droc Gabriela , Grintescu Ioana Marina , Mirea Liliana
Published: November 2022

Background: The fish-based diet is known for its potential health benefits, but it is less known for its association with mercury (Hg) exposure, which, in turn, can lead to neurological and cardiovascular diseases through the exacerbation of oxidative stress. The aim of this study was to evaluate the correlations between Hg blood concentration and specific biomarkers for oxidative stress. Methods: We present a cross-sectional, analytical, observational study, including primary quantitative data obtained from 67 patients who presented with unspecific complaints and had high levels of blood Hg. Oxidative stress markers, such as superoxide dismutase (SOD), glutathione peroxidase (GPX), malondialdehyde (MLD), lymphocyte glutathione (GSH-Ly), selenium (Se), and vitamin D were determined. Results: We found positive, strong correlations between Hg levels and SOD (r = 0.88, p < 0.0001), GPx (r = 0.92, p < 0.0001), and MLD (r = 0.94, p < 0.0001). We also found inverted correlations between GSH-Ly and vitamin D and Hg blood levels (r = −0.86, r = −0.91, respectively, both with p < 0.0001). Se had a weak correlation with Hg plasma levels, but this did not reach statistical significance (r = −0.2, p > 0.05). Conclusions: Thus, we can conclude that low-level Hg exposure can be an inductor of oxidative stress.
A Reinforcement-Learning-Based Model for Resilient Load Balancing in Hyperledger Fabric
Authors: Alotaibi Reem , Alassafi Madini , Bhuiyan Md. Saiful Islam , Raju Rajan Saha , Ferdous Md Sadek
Published: November 2022

Blockchain with its numerous advantages is often considered a foundational technology with the potential to revolutionize a wide range of application domains, including enterprise applications. These enterprise applications must meet several important criteria, including scalability, performance, and privacy. Enterprise blockchain applications are frequently constructed on private blockchain platforms to satisfy these criteria. Hyperledger Fabric is one of the most popular platforms within this domain. In any privacy blockchain system, including Fabric, every organisation needs to utilise a peer node (or peer nodes) to connect to the blockchain platform. Due to the ever-increasing size of blockchain and the need to support a large user base, the monitoring and the management of different resources of such peer nodes can be crucial for a successful deployment of such blockchain platforms. Unfortunately, little attention has been paid to this issue. In this work, we propose the first-ever solution to this significant problem by proposing an intelligent control system based on reinforcement learning for distributing the resources of Hyperledger Fabric. We present the architecture, discuss the protocol flows, outline the data collection methods, analyse the results and consider the potential applications of the proposed approach.
Electrochemical Oxidation of Anastrozole over a BDD Electrode: Role of Operating Parameters and Water Matrix
Authors: Dhawle Rebecca , Frontistis Zacharias , Mantzavinos Dionissios
Published: November 2022

The electrochemical oxidation (EO) of the breast-cancer drug anastrozole (ANZ) is studied in this work. The role of various operating parameters, such as current density (6.25 and 12.5 mA cm−2), pH (3–10), ANZ concentration (0.5–2 mg L−1), nature of supporting electrolytes, water composition, and water matrix, have been evaluated. ANZ removal of 82.4% was achieved at 1 mg L−1 initial concentration after 90 min of reaction at 6.25 mA cm−2 and 0.1 M Na2SO4. The degradation follows pseudo-first-order kinetics with the apparent rate constant, kapp, equal to 0.022 min−1. The kapp increases with increasing current density and decreasing solution pH. The addition of chloride in the range 0–250 mg L−1 positively affects the removal of ANZ. However, chloride concentrations above 250 mg L−1 have a detrimental effect. The presence of bicarbonate or organic matter has a slightly negative but not significant effect on the process. The EO of ANZ is compared to its degradation by solar photo-Fenton, and a preliminary economic analysis is also performed.
Personal Jesus: Reflections on God’s Call
Authors: Wright J. Lenore , Arterbury Andrew E.
Published: November 2022

This essay argues that contemporary conceptions of “calling” do not properly reckon with the concept’s biblical and historical foundations. In popular culture, where celebrities and social media influencers wield power, religious language is often extracted from faith traditions without regard for the tradition’s identity or communal nature. Calling, in this manner, has become a cultural catch-phrase devoid of vocational meaning. For many young, American Christians, including those taught by the authors, calling primarily bears a psychosocial meaning: calling signifies personal or economic fulfillment. Even students who are zealous for their faith tend to read the concept of “calling” within cultural norms rather than the biblical narratives or the Christian tradition’s theological insights. The authors present the biblical examples of Moses and Saul (or Paul) to critique contemporary cultural assumptions about calling. They argue that calling is and ought to be a process that is thoroughly dialogical (with God and community), embraces challenges rather than seeking personal stability, and foregrounds the simple act of following Christ’s call and example in daily life.
The Scramble for Religion and Secularism in Pre-Colonial Africa
Authors: Igboin Benson Ohihon
Published: November 2022

The debate on the existence of religion in Africa is far from over; it reverberates in new dimensions but asking the same old questions in newer ways. The same argument is being extended to secularism. This article takes a critical look at the concepts, religion and secularism in sub-Saharan pre-colonial Africa, raising the recurring question still maintained by the West whether there was ‘religion’ in Africa at the turn of colonialism. It argues that where no religion exists, the notion of secularism as understood by the West, cannot also exist since the latter is not just the ‘opposite’ of the former, but in actual fact, streams from it. However, since the position of ‘non-religion’ in Africa could not be sustained by the West, the question of how and why ‘secularism’ was not also ‘discovered’ in pre-colonial Africa spontaneously arises. Not denying the widespread diversities of religious beliefs in pre-colonial Africa, this paper argues for the existence of religion, and presence and praxis of religio-secularity, which is non-atheistic in nature that also foregrounds the practice of ‘secularity’ in post-colonial Africa.
A Study of Chinese Commentaries on the Sutra of Perfect Enlightenment
Authors: Wang Kai
Published: November 2022

The Sutra of Perfect Enlightenment, also known as Yuanjuejing 圓覺經 or, in full, Dafang guangyuanjue xiuduoluo liaoyijing 大方廣圓覺修多羅了義經, is a mindfulness meditation sutra with a particularly high reputation that has been the subject of a great deal of annotations and commentaries throughout the history of East Asian Buddhism. However, hitherto, the literature has not systematically organized and studied these annotations and commentaries. The aim of this paper is to organize the Chinese commentaries on this sutra from the 8th to the 17th centuries systematically and tointroduce the different situations by the commentaries produced by different schools of Buddhism. Briefly, these works mainly include the commentaries by Weique 惟愨, Wushi 悟實, Jianzhi 堅志, Daoquan 道詮, and Tsung-mi 宗密 during the Tang Dynasty (618–907); the commentaries of the Huayan 華嚴宗, Tiantai 天臺宗, and Chan 禪宗 schools during the Song Dynasty (960–1279); and the literal interpretations and collected commentaries produced during the Ming and Qing Dynasties (1368–1912).
Spinoza’s Defense of Democracy and the Emergence of Secularism
Authors: Frankel Steven H.
Published: November 2022

Prof. Stephen Strehle’s recent study suggests that modern politics is informed by secularism, which tends to promote hostility toward religion and the desire to purge religion from the public sphere. This essay considers one of the founding documents of secularism and modern political thought, Spinoza’s Theologico-Political Treatise. Spinoza’s account is ambiguous: his theology raises doubts about the truth of revelation even as he argues that salvation, as taught by the Bible, requires the practice of caritas. Spinoza also attempts to separate religion and politics. He grounds political life on universal natural rights and directs it toward the pursuit of comfort and security rather than salvation. This teaching appears to neglect the extraordinary possibilities and peaks of human life, both intellectual and spiritual. Spinoza’s account appears to support Prof. Stehle’s concern that such a single-minded focus on material comfort will lead ultimately to a debasement of humanity, and a confusion or denial of the distinction between high and the low.
Siri 2.0—Conversational Commerce of Social Bots and the New Law of Obligations of Data: Explorations for the Benefit of Consumer Protection
Authors: Gesmann-Nuissl Dagmar , Meyer Stefanie
Published: November 2022

The possibilities and reach of social networks are increasing, designs are becoming more diverse, and ideas more visionary. Most recently, the former company “Facebook” announced the creation of a metaverse. With these technical possibilities, however, the danger of fraudsters is also growing. Using social bots, consumers are increasingly influenced on such platforms and business transactions are brought about through communication, i.e., conversational commerce. Minors or the elderly are particularly susceptible. This technical development is accompanied by a legal one: it is permitted by the Digital Services Directive and the Sale of Goods Directive to demand the provision of data as consideration for the sale of digital products. This raises legal problems at the level of the law of obligations and data protection law, whose regulations are intended to protect the aforementioned groups of individuals. This protection becomes even more important the more gullible consumers are influenced by communicative bots. We show that there is a lack of knowledge about what value objective data can have in business transactions. The sufficient transparency of objective data value can maintain legal protection, especially of vulnerable groups, and ensure the purpose of the laws.