bluuebunny/crossref_metadata_2025 huggingface dataset:
Sunitinib in the treatment of renal cell carcinoma: an update on recent evidence
Authors: Rizzo Mimma , Porta Camillo
Published: June 2017

Sunitinib is a multitarget tyrosine kinase inhibitor endowed mainly by antiangiogenic effects, although an indirect inhibitory effect on tumor growth and, more recently, a complex activity on antitumor immune response has been described. From approval by the US Food and Drug Administration (FDA) in January 2006, sunitinib represents a key molecule in the treatment of metastatic renal cell carcinoma (mRCC) due to the peculiar molecular pathogenesis of this neoplasm. Over the past 10 years, clinical trials and real-world experiences helped clinicians to understand how, when and for how long to use sunitinib. Although a huge amount of data evidenced the relationship existing between sunitinib dose intensity and improved clinical outcome, the management of sunitinib-induced adverse events is often complex; thus, alternative schedules have been proposed over time which allow increased tolerability, without decreased daily sunitinib exposure, leading to improved clinical outcomes. To date, combinations of sunitinib with other approved targeted agents did not demonstrate any significant benefit over its single-agent use, mainly due to tolerability issues. Sunitinib has also been tested in the adjuvant setting, within the ASSURE and S-TRAC trials, with opposite results; indeed, equivocal risk-stratification criteria, as well as immature overall survival (OS) data prevent any definitive conclusion on this important issue. Despite being on the market for a long time, sunitinib still plays a role as the ‘comparator arm’ of a number of trials in the field of mRCC. Combinations with immune checkpoint inhibitors and vaccines look promising; once again, sunitinib can help us to optimize mRCC management.
The philosophy of ‘unity of knowledge and action’ in interventional neuroradiology teaching
Authors: Lv Xianli , Wu Zhongxue
Published: June 2017

Despite the continuing emphasis on the importance of clinical skills, these skills do not appear to be improving and may actually be declining. The ‘unity of knowledge and action’ is a medicine directed precisely at this disease. The ‘unity of knowledge and action’ helps to learn from failure and successes, learn from mistakes of predecessors and institute a behaviour that prevents repetition of these mistakes.
The relationship between infant peer interactions and cognitive development: Evidence from rural China
Authors: Yue Ai , Wang Xiaohong , Yang Sha , Shi Yaojiang , Luo Renfu , Zhang Qi , Kenny Kaleigh , Rozelle Scott
Published: June 2017

Social interactions in infancy have implications for long-term outcomes. This study uses data from a sample of 1412 rural Chinese infants aged 6–12 and 24–30 months to examine the relationship between peer interactions and cognitive development. Over 75% of the infants in this sample had less than three peers and around 20% had no peers in both periods. The prevalence of cognitive delays is high within this sample and increases as infants age. Multivariate analysis reveals that peer interaction is significantly associated with cognitive development. Heterogeneous analysis suggests that peer interactions and mental development may be related to the child’s primary caregiver and the distance from the child’s household to the center of their village.
The Emergence and Management of Role Ambiguity in a Collegiate Basketball Team
Authors: Kang Paul , Seibold David R.
Published: June 2017

Role ambiguity—the lack of clear, consistent information regarding one’s role, responsibilities, or position—is a critical factor in team sports in which alignment of roles is vital to collective performance and team success. However, how role ambiguity evolves over time and is managed is understudied. This qualitative longitudinal investigation examined how role ambiguities emerged and impacted the members of a National Collegiate Athletic Association Division I collegiate men’s basketball team. Working within the organizational tensions theoretical framework, data on role ambiguity were collected through participant observation and ethnographic interviews and thematically coded and analyzed. Findings indicated that role ambiguities, such as with player leadership, were influenced by numerous contextual factors and recursively influenced the meanings of some of those factors. These complexities also produced tensions, and members’ attempts to manage these tensions produced dualities that further increased role ambiguity. When members realized they could not resolve ambiguities related to their roles, they concocted unorthodox role management strategies to accomplish their responsibilities amidst the ambiguity.
Posterior hip approach yields better functional results vis-à-vis anterolateral approach in total hip arthroplasty for patients with severe hip dysplasia: A prospective randomized controlled clinical study
Authors: Çatma Faruk Mehmet , Öztürk Alper , Ünlü Serhan , Ersan Önder , Altay Murat
Published: June 2017

Objectives:

We aimed to compare functional outcomes of two common hip approaches for patients with severe hip dysplasia in total hip replacement (THR) surgery.

Materials and methods:

Seventy hips of 68 patients randomized into two groups with regard to hip approach as posterior (group I) and anterolateral (group II). All patients underwent THR surgery with femoral shortening osteotomy. The groups were compared for operation time, preoperative and 6 months after abductor muscle strengths (AMSs), gait disorders, union time of the osteotomied site and dislocation rates.

Results:

There were two early dislocations in group I, and two early and one late dislocations in group II. No significant difference was observed regarding hip dislocations. Mean union time of the osteotomied site was 113.9 ± 51 days in group I while 111.1 ± 29.3 days in group II ( p = 0.774). Six months after surgery, group I had higher AMS than group II ( p < 0.0001). More patients in group II had Trendelenburg gait pattern ( p = 0.043), while no difference was observed regarding antalgic and deviated gait patterns between groups.

Conclusion:

THR surgery for patients with severe developmental dysplasia of hip is a challenging procedure, and posterior approach provides better functional outcomes regarding gait and AMSs.
Testing the Performance of Graham’s Net Current Asset Value Strategy in Indian Stock Market
Authors: Singh Jaspal , Kaur Kiranpreet
Published: June 2017

Using the data on stocks listed on Bombay Stock Exchange (BSE) for the period spanning from 1996 to 2010, the present study intends to examine the relevance of stock selection based on net current asset value rule of Benjamin Graham in Indian capital market. This valuation metric is aimed at buying the securities whose prices are lesser than the net current assets of the company. The returns derived from the stocks meeting the criterion are analysed using one sample t-test, capital asset pricing model (CAPM). The results revealed that the portfolio selected on the basis of this criterion provided significantly positive mean market adjusted returns in maximum number of years when the holding period of the portfolio is extended from 12 months to 24 months. The significant abnormal returns derived through CAPM model, however, cannot be considered conclusive due to lesser explanatory power of the model. Nevertheless, the portfolio showed lesser volatility than the market portfolio, thereby implying that the fund managers can also use it as an investment tool for risk management due to lesser risk and positive market adjusted returns.
Application of Taguchi Method of Experimental Design for Chemical Process Optimisation: A Case Study
Authors: Patyal Vishal Singh , Modgil Sachin , Maddulety K.
Published: June 2017

This case study is one of the distinctive researches which highlight the factor ratings and process optimisation through Taguchi design. This research has been conducted with a special reference to chemical plants in India. The objective of the present study was to establish optimal setting of four factors, viz., ( i) temperature (°C), ( ii) percentage of chemical (Borex), ( iii) pH and ( iv) time (Hrs). The present study was conducted to ensure optimisation of two response variables which were ( i) Loss-on-Ignition (LoI) (lower the better) and ( ii) chemical Borate content (higher the better). The unique 10 step methodology was adopted for arriving at optimal setting of four factors. Validation of optimal settings has been done by comparing actual values (means and signal to noise [S/N] ratios) for optimal setting with predicted values (means and S/N ratios). The results show that the Taguchi parameter design improves the response variables ( i) LoI (lower is better) and ( ii) chemical Borate content (higher is better), as the Taguchi L9 experiment resulted in lower LoI (less than 15 per cent) and high Borate percentage of chemical (greater than 45 per cent). The optimisation of response variables has ensured breakthrough improvement in the manufacturing process of Zinc Borate. The result underlines effectiveness of Taguchi optimisation technique.
Relationship between Indian Spot and Future Crude Oil Prices: A Phasewise Empirical Analysis
Authors: Chhatwal Haritika , Puri Himanshu
Published: June 2017

The present article explores the dynamic relationship between the spot and future prices of crude oil commodity in Indian context. The prime objective of the study is to check the long-term and cause and effect relationship between the variables selected, that is, spot prices and future prices of crude oil. The objectives of the study are examined by employing Augmented Dickey–Fuller (ADF) test to check the stationarity, Johansen’s co-integration test for examining the long-term relationship and Granger causality test to know the cause and effect relationship between spot and the future prices of crude oil. The daily closing data is taken from 1 May 2005 to 31 December 2012 for the analysis. Since the period of financial crisis is considered, the entire period (May 2005–December 2012) is divided into three sub-periods, namely before crisis period (May 2005–August 2008), during crisis (September 2008–December 2010) and after crisis period (January 2011–December 2012). The findings of the study proved that the series derived from the future prices and cash market prices for crude oil were not stationary in the level form, but there is an evidence of stationarity in the first difference form. Empirical results found that there is unidirectional causality from spot return to futures return for before crisis period. For the during crisis period, there is bi-directional feedback from futures return to spot return and from spot return to futures return. A unidirectional relationship between spot returns and futures return for the period after crisis is also observed.
The E-Waste Legislation and Contemporary Sustainability Issues in India: A Critical Analysis
Authors: Yadav Shiv Shankar Kumar , Bandyopadhayay Asit
Published: June 2017

Sustainability or more precisely sustainable development is the term which has been defined by the World Commission on Environment and Development (WECD) as a way or style of development of fulfilling today’s requirements without compromising tomorrow’s fulfilment of requirements. Sustainability nowadays is very crucial whether it is about development in infrastructure or environment related or about sustainability of a business processes in a corporate. This article represents a critical review on the various legal rules and regulations available in India to address the problem of environmental protection with special reference to electronic waste (e-waste). The article also focuses on the pros, cons and unattended issues available in the real-time environment due to comparatively feeble e-waste legislation in the available regulatory framework. The basic objective of this article is to explore and assess the amount and type of change in the overall sustainable development in the post-implementation era of the e-waste legislation.
Interaction of Institutional Investment Activity and Stock Market Volatility: Evidence from India
Authors: Naik Pramod Kumar , Padhi Puja
Published: June 2017

This study examines the dynamic interaction of institutional fund flows and stock returns volatility using daily data. Foreign institutional investors (FIIs) and mutual funds’ net equity investment have been considered simultaneously using the vector auto-regression (VAR) model. The findings show that both mutual funds’ as well as FIIs’ net investment on equity jointly influences the stock market. While the mutual funds’ net investments positively influence stock market volatility, the FIIs’ net investments negatively impact volatility. However, in the presence of market fundamentals, it is found that FII’s net flow does not show significant influence on market volatility, but mutual funds net flow has a significant impact on market volatility at least at the second lags. It has also been observed that the investment activities of FIIs and mutual funds are interrelated. Causality test indicates that there exists a bidirectional causation between FII’s net flow and market volatility, whereas mutual funds flows do not cause volatility.
Literacy Geography and Pedagogy
Authors: Comber Barbara
Published: June 2017

This article explores the possible relationships between geography, literacy, pedagogy, and poverty. It characterizes poverty as a wicked problem, which sees economic inequality escalating in a number of neoliberal democracies. Key insights from theorists of economic inequality are summarized. The enduring nature of poverty in particular places is noted, and the associated risks of “fickle literacies” are considered. A case study of one child growing up and attending school in a location with intergenerational unemployment is discussed as an example of the risks associated with literacy policy and pedagogy in an era of global educational reform. Drawing on the work of Foucault and Massey, it is argued that despite the discourses of standardization, teachers can continue to educate culturally diverse young people in ways that help them to negotiate and imagine positive and productive ways of learning together. The possibilities for working against deficit views of people in poverty are explored through three classroom examples of place-conscious pedagogies which position young people as critically literate cosmopolitan citizens. The article concludes by advocating the need for translocal research alliances to work explicitly for social justice through place-conscious pedagogies and critical literacy education.
Paper-reinforced sodium alginate/carboxyl methyl cellulose-based bio-composite films
Authors: Kale Ravindra D , Maurya Yashlok , Potdar Tejasvi
Published: June 2017

Waste paper-reinforced sodium alginate/carboxymethyl cellulose (NaCMC)-based bio-composite films were prepared by solution casting method by optimum combination of 1.5% sodium alginate and 1.5% NaCMC. The optimum combination was selected on the basis of good tensile strength and low moisture sensitivity. This film was further subjected to aqueous solution of potassium aluminium sulphate (potassium alum) to reduce water vapour permeability and moisture content. This potassium alum solution treatment further enhanced the mechanical and thermal properties, and the film biodegradability was not affected either due to the cross linking or colour addition, which has potential as a substitute for the currently used polyethylene-based films. Molecular interactions between polymers and potassium alum affected mechanical, thermal, and other properties and was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, energy dispersive X-ray, and thermo gravimetric analysis of the films. This bio-composite film may be suitable to replace non-biodegradable and costly biodegradable packaging materials.
KLF1 drives the expression of fetal hemoglobin in British HPFH
Authors: Wienert Beeke , Martyn Gabriella E. , Kurita Ryo , Nakamura Yukio , Quinlan Kate G. R. , Crossley Merlin
Published: June 2017

Key Points

Introduction of the British HPFH mutation into the fetal globin promoter in a human cell model causes elevated fetal globin expression. The British HPFH mutation creates a de novo binding site both in vitro and in vivo for the potent erythroid activator KLF1.
DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions
Authors: Buscarlet Manuel , Provost Sylvie , Zada Yassamin Feroz , Barhdadi Amina , Bourgoin Vincent , Lépine Guylaine , Mollica Luigina , Szuber Natasha , Dubé Marie-Pierre , Busque Lambert
Published: June 2017

Key Points

Somatic mutations driving clonal hematopoiesis occur mainly in DNMT3A and TET2 and have no significant impact on hematological phenotypes. There is a familial predisposition to acquire TET2 mutation.
A framework for quantification and physical modeling of cell mixing applied to oscillator synchronization in vertebrate somitogenesis
Authors: Uriu Koichiro , Bhavna Rajasekaran , Oates Andrew C. , Morelli Luis G.
Published: June 2017

In development and disease, cells move as they exchange signals. One example is found in vertebrate development, where the timing of segment formation is set by a “segmentation clock” in which oscillating gene expression is synchronized across a population of cells by Delta-Notch signaling. Delta-Notch signaling requires local cell-cell contact, but in the zebrafish embryonic tailbud oscillating cells move rapidly, exchanging neighbors. Previous theoretical studies proposed that this relative movement or cell mixing might alter signaling and thereby enhance synchronization. However, it remains unclear whether the mixing timescale in the tissue is in the right range for this effect, because a framework to reliably measure the mixing timescale and compare it with signaling timescale is lacking. Here, we develop such a framework using a quantitative description of cell mixing without the need for an external reference frame, and constructing a physical model of cell movement based on the data. Numerical simulations show that mixing with experimentally observed statistics enhances synchronization of coupled phase oscillators, suggesting that mixing in the tailbud is fast enough to affect the coherence of rhythmic gene expression. Our approach will find general application to analyzing the relative movements of communicating cells during development and disease.
Towards a complete generic‐level plastid phylogeny of the paleotropical woody bamboos (Poaceae: Bambusoideae)
Authors: Zhou Meng-Yuan , Zhang Yu-Xiao , Haevermans Thomas , Li De-Zhu
Published: June 2017

Paleotropical woody bamboos (PWB) are phylogenetically and taxonomically intractable. Because previous studies included deficient samples or lacked informative characters for tree construction, phylogenetic relationships within the PWB remain incompletely resolved. This study presents the most extensively sampled phylogeny of the PWB with 18 plastid regions and a sample of 144 (35%) ingroup species representing 40 (85%) genera and 8 outgroup species. Results confirmed Melocanninae as the earliest diverging lineage from the rest of the group, and Hickeliinae (including Nastus s.str.) and Racemobambosinae are separately placed within the PWB. Bambusinae is phylogenetically heterogeneous and consists of the Dinochloa-Greslania-Mullerochloa-Neololeba-Sphaeroambos (DGMNS) assemblage, Temburongia simplex, and the core Bambusinae. The core Bambusinae may be redefined to include a basal grade, which contains Kinabaluchloa, Holttumochloa, Bonia, Neomicrocalamus, Temochloa, Soejatmia and an unidentified taxon, and the Bambusa-Dendrocalamus-Gigantochloa (BDG) complex. The BDG complex is extremely diverse in morphology and is subdivided into six subclades. Within the Melocanninae, Davidsea, Neohouzeaua and Ochlandra are closely related to Schizostachyum. Phylogenetic relationships are mostly supported by morphological and geographical evidence. In addition, novel interpretations are provided in the redelimitation of some taxa.
Em busca da emancipação na gestão do conhecimento
Authors: Ferraz Janaynna De Moura , Sales Jefferson
Published: June 2017

A gestão do conhecimento tem se consolidado nos discursos acadêmicos e nas práticas das organizações particulares e públicas especialmente nas três últimas décadas. Discursivamente a gestão do conhecimento se apresenta como meio eficiente e eficaz para conduzir organizações modernas, por meio da promoção de um ambiente de autonomia e valorização humana. Diante do paradoxo sob o qual tal pretensão se edifica a proposta deste ensaio consiste em perscrutar a gestão do conhecimento à luz da teoria crítica para investigar se há alguma possibilidade de emancipação nas organizações. Dentre as principais inflexões, defende-se que a criação de conhecimento corporativo, que poderia ser um caminho para melhoria da vida da população, tem sido direcionada, em maior medida, para atender aos interesses do capital, em detrimento dos interesses da humanidade. Não obstante, frente às contradições da teoria de criação do conhecimento como instrumento de controle do capital, desconfia-se que o conhecimento tácito poderia ter uma lacuna pela qual a luz da emancipação poderia penetrar.
РАЗЛИЧИЯ МОРАЛИ, ГРУППОВОЙ ИДЕНТИЧНОСТИ И ИЗМЕНЯЕМОСТИ ЛИЧНОСТИ В ЗАВИСИМОСТИ ОТ ОБРАЗОВАНИЯ
Authors: Kolinichenko Irina Aleksandrobna
Published: June 2017

Цель. Статья посвящена изучению различий морального развития и категорий идентичности у молодых людей, различающихся по уровню завершенности образования.Метод. Изучение моральных различий проводилось нами с использованием метода дилемм, предложенных Л. Колбергом в модификации, а категорий идентичности при помощи методики М. Кун «Тест двадцати утверждений» также в модификации. Статистический анализ значимых различий между средними значениями проводился с помощью U-критерия Манна-Уитни пакета Statistica for Windows 8.Результаты. Результаты исследования выявили доминирование всех выделенных параметров оценки в группе испытуемых с незаконченным высшим образованием: более высокий уровень морального развития по всем дилеммам (противопоставлении ценностей жизни (сострадания) и следования закону, личной выгоды – интересов города (закона), бизнеса (выгоды) и закона, личных интересов (карьеры) и свободы другого человека) кроме дилеммы о противопоставлении интересов большинства и одного человека. Также выявились различия между двумя группами испытуемых по групповой идентичности, групповой изменяемости, желательности общих категорий идентичности.
Accounting in Public Institutions (state, budgetary, independent)
Authors: Василенко Марина , Vasilenko Marina , Полещук Татьяна , Poleschuk Tat'yana
Published: June 2017

This tutorial presents the procedure of accounting in public institutions; peculiarities of functioning of the state-owned, budgetary and Autonomous institutions, the legal regulation of budget activities; in detail the sections of nonfinancial and financial assets, liabilities. For each section of the accounting documents is defined and given a system of accounting entries. Attention is paid to the practice of accounting in the medical and educational institutions. Designed for students, undergraduates, postgraduates and teachers of economic specialties. It will be useful to specialists in economic Affairs in the public sector.
Comparing temperature of subauroral mesopause over Yakutia with SABER radiometer data for 2002–2014
Authors: Аммосова Анастасия , Ammosova Anastasiya , Гаврильева Галина , Gavrilyeva Galina , Аммосов Петр , Ammosov Petr , Колтовской Игорь , Koltovskoi Igor
Published: June 2017

We present the temperature database for the mesopause region, which was collected from spectral measurements of bands O2(0-1) and OH(6-2) with the infrared spectrograph SP-50 at the Maimaga station (63° N; 129.5° E) in 2002–2014. The temperature time series covers 11-year solar cycle. It is compared with the temperature obtained with the Sounding of the At-mosphere using Broadband Emission Radiometry in-strument (SABER, v.1.07 and v.2.0), installed onboard the TIMED satellite. We compare temperatures meas-ured during satellite passes at distances under 500 km from the intersection of the spectrograph sighting line with the hydroxyl emitting layer (~87 km) and oxygen emitting layer (~95 km). The time criterion is 30 min. We observe that there is a seasonal dependence of the difference between the ground-based and satellite measurements. The data obtained using SABER v2.0 show good agreement with the temperatures measured with the infrared digital spectrograph. The analysis we carried out allows us to conclude that a series of rotational temperatures obtained at the Maimaga station can be used to study temperature variations on different time scales including long-term trends at the mesopause height
Monitoring and investigating space weather effects with meridional chain of instruments in Yakutia: a brief overview
Authors: Баишев Дмитрий , Baishev Dmitry , Самсонов Сергей , Samsonov Sergey , Моисеев Алексей , Moiseev Aleksey , Бороев Роман , Boroev Roman , Степанов Александр , Stepanov Aleksandr , Козлов Владимир , Kozlov Vladimir , Корсаков Алексей , Korsakov Aleksey , Торопов Анатолий , Toropov Anatoliy , Йошикава Акимаса , Yoshikawa Akimasa , Юмото Киёхуми , Yumoto Kiyohumi
Published: June 2017

The Yakutsk Meridional Chain (YMC) of IKFIA SB RAS, located along the 190° magnetic meridian, is equipped with geophysical and radiophysical instruments for monitoring space weather in northeast-ern Russia. YMC includes four basic stations in Yakutsk, Tixie, Zhigansk, and Maymaga, and six additional observation sites in Neryungri, Zyryanka, Kystatyam, Dzhardzhan, Chokurdakh, and Kotelny Island. It provides continuous monitoring of near-Earth space in order to obtain data on magnetic field variations, cosmic radio noise, VLF radiation, and ionospheric parameters in the complex upper atmosphere – ionosphere –magnetosphere system. In addition, long-term experimental research into space weather effects on human health is conducted at Tixie and Yakutsk. The report describes the meridional chain of instruments at subauroral and auroral latitudes and gives a brief overview of scientific results of monitoring and investigation into space weather effects in Yakutia. It also observes participation of IKFIA SB RAS in international projects (Intermagnet, MAGDAS, GIRO).
Construction of a century solar chromosphere data set for solar activity related research
Authors: Ганхуа Линь , Ganghua Lin , Сяо-Фань Ван , Xiao Fan Wang , Сяо Ян , Xiao Yang , Со Лю , Suo Liu , Мэй Чжан , Mei Zhang , Хайминь Ван , Haimin Wang , Чан Лю , Chang Liu , Янь Сюй , Yan Xu , Тлатов Андрей , Tlatov Andrey , Демидов Михаил , Demidov Mikhail , Боровик Александр , Borovik Aleksandr , Головко Алексей , Golovko Aleksey
Published: June 2017

This article introduces our ongoing project “Construction of a Century Solar Chromosphere Data Set for Solar Activity Related Research”. Solar activities are the major sources of space weather that affects human lives. Some of the serious space weather consequences, for instance, include interruption of space communication and navigation, compromising the safety of astronauts and satellites, and damaging power grids. Therefore, the solar activity research has both scientific and social impacts. The major database is built up from digitized and standardized film data obtained by several observatories around the world and covers a timespan more than 100 years. After careful calibration, we will develop feature extraction and data mining tools and provide them together with the comprehensive database for the astronomical community. Our final goal is to address several physical issues: filament behavior in solar cycles, abnormal behavior of solar cycle 24, large-scale solar eruptions, and sympathetic remote brightenings. Significant progresses are expected in data mining algorithms and software development, which will benefit the scientific analysis and eventually advance our understanding of solar cycles.
The parameters of cardio-vascular system in conditions of external influences
Authors: Белощенко  , Beloshchenko D. , Башкатова  , Bashkatova Yuliya , Филатова  , Filatova D. , Мороз  , Moroz O.
Published: June 2017

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CONCEPTUAL FRAMEWORK OF “TURQUOISE ORGANIZATIONS” AND REALIZATION PROSPECTS IN PERSONNEL MANAGEMENT
Authors: Чуланова  , Chulanova Oksana
Published: June 2017

The experience of using turquoise organizations has long been used abroad. Turquoise organizations are the so-called “living” organizations, working on the principle of a single organism, a living system: flexibly reacting to the changes taking place, making decisions on an intuitive level and subtly feeling its internal and external processes. In working with the personnel of Russian organizations it is a new technology that is of interest from the point of view of theorists and practitioners. The article attempts to define the conceptual basis of this technology taking into account the principles, mechanisms and expected results of the functioning of turquoise organizations. The article presents the essence, basic principles of turquoise organizations. The advantages and disadvantages of this form of management interaction are indicated. The article presents the foreign experience of turquoise organizations and the pilot project of the Russian organization. The prospects of using this innovative technology in working with the staff of modern domestic organizations are indicated.
The Nonlinear Forms in Engineering Geometry
Authors: Иванов  , Ivanov Gennadiy , Дмитриева  , Dmitrieva I.
Published: June 2017

The introduction of the methodology of a competence approach in teaching the courses of departments of engineering graphics, as shows the experience of a number of technical universities of Russia, occurs according to some template. If in 70–80 years the last century the Departments was the routing of the teaching subject with the indication providing, and provide discipline then currently are talking about interdisciplinary competences. In this case, interdisciplinary competence on engineering and computer graphics define the departments. The wording of the intrasubject competencies reduced to define the topics of descriptive geometry necessary for the study of the fundamentals of engineering graphics (geometrical and projection drawing, the cutting line and the intersection of simple surfaces). In the end, the important topics of descriptive geometry (basic concepts of the theory of curves and surfaces, sweep, tangent planes, axonometric etc.) that have practical value, are excluded from the syllabus. This greatly affects the quality overall geometric training of students of technical universities with based on the level of teaching geometry in high school. In our opinion, the way out of the situation is in consistent, purposeful transformation the descriptive geometry in the engineering geometry without radical distortions. In this regard, the present article is devoted to the presentation some issues in the theory of nonlinear forms in engineering geometry. The proposed approach will enhance the practical value of our discipline due to the expansion of cross-curricular competencies with related sections of higher mathematics, CAD, etc.
Sexual dysfunction among women with type 2 diabetes and its relationship with well-being, anxiety and depression
Authors: Klocek Joanna , Ostasz- Ważny Joanna , Krzyczkowska-Bokwa Ewa , Freeman Clevenger Sharon , Kokoszka Andrzej
Published: June 2017

Aim of the study

To examine whether Polish women with type 2 diabetes suffer from sexual dysfunction/dissatisfaction, and if so, to investigate the connection between the severity of sexual problems and well-being, anxiety and depression in this group of women.

Subject or material and methods

We surveyed 60 women aged 42-72 years old, M = 59.25 (SD = 9.14). The study was based on the following questionnaires: the Arizona Sexual Experience Scale (ASEX), Sexological Questionnaire Part B, the WHO-5 Well-Being Index, the Brief Self-Rating Scale of Depression and Anxiety.

Results

A total of 75% (N = 45) of the respondents complained of the absence of orgasm (anorgasmia), 63.3% (N = 38) showed a lack or loss of sexual desire, and 50% (N = 30) had no genital response to sexual stimuli and/or experienced sexual aversion. There was also no significant relationship between wellbeing, the presence of anxiety and depressive symptoms, and the severity of sexual dysfunction.

Discussion

The current study has significant limitations due to the small number of participants and the lack of a pair matched control group. Our findings indicate higher frequency of SD than other studies. The differences should be interpreted with caution and it would be important to confirm these results in future studies, with a larger group of participants.

Conclusions

Polish women with type 2 diabetes commonly have symptoms of sexual dysfunction. Well-being, depressive and anxiety symptoms appear to co-occur with symptoms of sexual dysfunctions.
Optimal Allocation of Students to Naval Nuclear-Power Training Units
Authors: Miller Michael R. , Alexander Robert J. , Arbige Vincent A. , Dell Robert F. , Kremer Steven R. , McClune Brian P. , Oppenlander Jane E. , Tomlin Joshua P.
Published: June 2017

The U.S. Navy operates an impressive fleet of nuclear-powered submarines and aircraft carriers and has safely operated its nuclear fleet for more than 60 years, while steaming over 154 million miles. Rigorous training has been key to maintaining such an impressive record. The U.S. Naval Nuclear Propulsion Training Program develops, certifies, and delivers the nuclear-operator qualification training for enlisted and officer personnel operating its nuclear fleet. This training finishes at one of four nuclear-power training units (NPTUs), operates under a complex set of hard and soft constraints, varies depending on the type of student, and requires significant personnel and equipment resources. We developed and implemented a mixed-integer linear program (MILP) that prescribes how many students of each type to allocate to each NPTU at the start of each class (a group of students who train together) and how allocated students complete NPTU training. The use of MILP has improved student allocation by an estimated eight percent and led to significantly improved use of both NPTU personnel and equipment resources. In this paper, we describe this unique optimization application, the MILP formulation, its path to adoption, its user interface, and impacts from its development and use over the past three years.
Closing the Productivity Gap: Improving Worker Productivity Through Public Relative Performance Feedback and Validation of Best Practices
Authors: Song Hummy , Tucker Anita L. , Murrell Karen L. , Vinson David R.
Published: June 2017

Public relative performance feedback (RPF) on an individual worker’s productivity metrics is used in various organizations with the hopes of improving worker productivity, but its effects are not well understood. We examine whether public RPF could be leveraged to facilitate adoption of best practices in an organization by enabling the validation of best practices shared by identifiable top performers. We use data from two emergency departments, both of which shared best practices for improving productivity and one of which changed from privately to publicly disclosing RPF to physicians. The public disclosure of RPF allowed workers to identify their top-performing coworkers, which in turn enabled the identification and validation of best practices within the work group. We find that the intervention is associated with a 10.9% improvement in physician productivity. We also find evidence for a significant reduction in variation in productivity across providers, which stems from bottom-ranked workers exhibiting differentially large improvements in productivity. These effects hold without sacrificing system-level performance, service quality, or worker attrition. Our results suggest that public disclosure of RPF, along with the validation of the best practices being shared, can improve worker productivity.

The online supplement is available at https://doi.org/10.1287/mnsc.2017.2745 .

This paper was accepted by Serguei Netessine, operations management.
When More Is Less: Field Evidence on Unintended Consequences of Multitasking
Authors: Goes Paulo B. , Ilk Noyan , Lin Mingfeng , Zhao J. Leon
Published: June 2017

Online customer service chats provide new opportunities for firms to interact with their customers and have become increasingly popular in recent years for firms of all sizes. One reason for their popularity is the ability for customer service agents to multitask (i.e., interact with multiple customers at a time) thereby increasing the system “throughput” and agent productivity. Yet little is known about how multitasking impacts customer satisfaction—the ultimate goal of customer engagements. We address this question using a proprietary data set from an S&P 500 service firm that documents agent multitasking activities (unobservable to customers) in the form of server logs, customer service chat transcripts, and postservice customer surveys. We find that agent multitasking leads to longer in-service delays for customers and lower problem resolution rates. Both lead to lower customer satisfaction, although the impact varies for different customers. Our study is among the first to document the link between multitasking and customer satisfaction, and it has implications for the design of agent time allocation in contact centers and more broadly for how firms can best manage customer relations in new service channels enabled by information technology.

The online appendix is available at https://doi.org/10.1287/mnsc.2017.2763 .

This paper was accepted by Lorin Hitt, information systems.
Corporate Cash Hoarding: The Role of Just-in-Time Adoption
Authors: Gao Xiaodan
Published: June 2017

I explore the role of the just-in-time (JIT) inventory system in the increase in cash holdings by U.S. manufacturing firms. I develop a model to illustrate the mechanism through which JIT affects cash and quantify its impact. In the model, both cash and inventory can serve as working capital. As firms switch from the traditional system to JIT, they shift resources from inventory to cash to facilitate transactions with suppliers. On average, this switchover accounts for a 4.1-percentage-point increase in the cash-to-assets ratio, which is approximately 28% of the change observed in the data.

Data are available at https://doi.org/10.1287/mnsc.2017.2775 .

This paper was accepted by Neng Wang, finance.
Fears that Ofsted's 15-day plan will add to inspection burden
Authors: Henshaw Pete
Published: June 2017

Planned changes to short inspections of ‘good’ schools could see a wait of up to 15 days if conversion to full inspection is needed
Radiation reduction of minimally invasive transforaminal lumbar interbody fusion with localisation system in overweight patients
Authors: Fan G. , Fu Q. , Zhang J. , Zhang H. , Gu X. , Wang C. , Gu G. , Guan X. , Fan Y. , He S.
Published: June 2017

Aims

Minimally invasive transforaminal lumbar interbody fusion (MITLIF) has been well validated in overweight and obese patients who are consequently subject to a higher radiation exposure. This prospective multicentre study aimed to investigate the efficacy of a novel lumbar localisation system for MITLIF in overweight patients.

Patients and Methods

The initial study group consisted of 175 patients. After excluding 49 patients for various reasons, 126 patients were divided into two groups. Those in Group A were treated using the localisation system while those in Group B were treated by conventional means. The primary outcomes were the effective radiation dosage to the surgeon and the exposure time.

Results

There were 62 patients in Group A and 64 in Group B. The mean effective dosage was 0.0217 mSv (standard deviation (sd) 0.0079) in Group A and 0.0383 mSv (sd 0.0104) in Group B (p <  0.001). The mean fluoroscopy exposure time was 26.42 seconds (sd 5.91) in Group A and 40.67 seconds (sd 8.18) in Group B (p < 0.001). The operating time was 175.56 minutes (sd 32.23) and 206.08 minutes (sd 30.15) (p < 0.001), respectively. The mean pre-operative localisation time was 4.73 minutes (sd 0.84) in Group A and 7.03 minutes (sd 1.51) in Group B (p < 0.001). The mean screw placement time was 47.37 minutes (sd 10.43) in Group A and 67.86 minutes (sd 14.15) in Group B (p < 0.001). The pedicle screw violation rate was 0.35% (one out of 283) in Group A and 2.79% (eight out of 287) in Group B (p = 0.020).

Conclusion

The study shows that the localisation system can effectively reduce radiation exposure, exposure time, operating time, pre-operative localisation time, and screw placement time in overweight patients undergoing MITLIF. Cite this article: Bone Joint J 2017;99-B:944–50.
Outcomes after early return to theatre following hip hemiarthroplasty for intracapsular fracture of the femoral neck
Authors: Mamarelis G. , Key S. , Snook J. , Aldam C.
Published: June 2017

Aims

Hip hemiarthroplasty is a standard treatment for intracapsular proximal femoral fractures in the frail elderly. In this study we have explored the implications of early return to theatre, within 30 days, on patient outcome following hip hemiarthroplasty.

Patients and Methods

We retrospectively reviewed the hospital records of all hip hemiarthroplasties performed in our unit between January 2010 and January 2015. Demographic details, medical backround, details of the primary procedure, complications, subsequent procedures requiring return to theatre, re-admissions, discharge destination and death were collected.

Results

A total of 705 procedures were included; 428 Austin Moore and 277 Exeter Trauma Stems were used. A total of 34 fractures (in 33 patients) required early return to theatre within 30 days. Age, gender, laterality, time from admission to primary procedure, American Society of Anesthesiologists grade, and implant type were similar for those requiring early return to theatre and those who did not. Early return to theatre was associated with a significantly higher length of stay (mean 33.6 days (7 to 107) versus 18.6 days (0 to 152), p < 0.001), re-admission rate (38.2% versus 8.6%, p < 0.001), and subsequent revision rate (17.6% versus 1.3%, p < 0.001). We found no difference in level of care required on discharge or mortality.

Conclusion

Proximal femoral fractures are common in the elderly population, with far-reaching medical and economic implications. Factors such as infection or dislocation may require early return to theatre, and this is associated with outcomes which may be both medically and economically detrimental. This illustrates the importance of avoiding early complications to improve longer term outcome. Return to theatre within 30 days is associated with longer length of stay, higher re-admission rate, and higher subsequent revision rate. It may be a useful short-term quality indicator for longer term outcome measures following hip hemiarthroplasty for intracapsular fractures of the proximal femur. Cite this article: Bone Joint J 2017;99-B:958–63.
Risk factors for wear-related failures after hip resurfacing in patients with a low contact patch to rim distance
Authors: Amstutz H. C. , Le Duff M. J. , Bhaurla S. K.
Published: June 2017

Aims

A contact patch to rim (CPR) distance of < 10 mm has been associated with edge-loading and excessive wear. However, not all arthroplasties with a low CPR distance show problems with wear. Therefore, CPR distance may not be the only variable affecting the post-operative metal ion concentrations.

Patients and Methods

We used multiple logistic regression to determine what variables differed between the patients who had high and low cobalt (CoS) and chromium (CrS) serum ion concentrations within a cohort of patients with low (< 10 mm) CPR distances. A total of 56 patients treated with unilateral hip resurfacing arthroplasty (HRA) had CoS and CrS ion studies performed more than one year after surgery. The mean age of the patients at the time of surgery was 51.7 years (29 to 70), with 38 women (68%) and 18 men (32%).

Results

It was seen that 47 patients had low ion levels (< 7µg/L) and nine had high ion levels (≥ 7µg/L). We found increased risks of high wear with decreasing CPR distance.

Conclusion

The use of CPR distance measurements to predict hips at risk for elevated wear is needed for all patients with HRA. We recommend that patients with low CPR distances have at least one serum ion study performed while patients with CPR distance > 10 mm do not need routine ion studies. We believe that patients with low CPR distance and low ions do not need repeat ion studies unless the patient becomes symptomatic or has substantial radiographic changes. Cite this article: Bone Joint J 2017;99-B:865–71.
Incarcerated Bochdalek hernia causing bowel obstruction in an adult male patient
Authors: Ekanayake EMNP , Fernando SA , Durairajah PL , Jayasundara JASB
Published: June 2017

Bochdalek hernias occur as a result of congenital fusion failure of the posterolateral muscular portion of the diaphragm derived from the embryonic pleuroperitoneal membrane. The vast majority of symptomatic Bochdalek hernias are diagnosed during the neonatal period. Congenital diaphragmatic hernias showing symptoms in adulthood are rare. We report the case of a 28-year-old man who presented with subacute bowel obstruction, later diagnosed to have a left-sided incarcerated Bochdalek hernia containing an ischaemic splenic flexure and the distal transverse colon. During laparotomy, he underwent primary repair of the diaphragmatic defect and an extended right hemicolectomy with ileocolic anastomosis. The patient made a good recovery and is well at three months following surgery. This case highlights the need for surgeons to be vigilant about rare types of congenital internal hernias as they may become symptomatic later in life.
An unexpected diagnosis of breast malignancy
Authors: Richardson T , Cottier F
Published: June 2017

Inflammatory breast cancer constitutes 5% of all breast cancer diagnoses. Diagnosis is based on clinical signs including skin changes, erythema and oedema, together with rapid progression and involvement of more than one-third of the affected breast. It is an aggressive tumour with great metastatic potential, metastases being present in 30% of patients at first presentation.

Primary non-Hodgkin’s lymphoma of the breast is rare but is well reported. It accounts for 0.5% of all breast malignancies and 1% of all non-Hodgkin’s diagnoses. Prognosis of primary breast lymphoma varies depending on the stage of disease with stage IE having a 5-year survival rate of 78–83% and stage IIE having a 5-year survival rate of 20–57%.

We present a rare case of non-Hodgkin’s lymphoma mimicking an inflammatory breast cancer. The aim of this case report is to highlight an unusual presentation of non-Hodgkin’s lymphoma and the diagnostic difficulties that arise.
The role of two-sided splinting for recalcitrant paediatric post-burn hand flexion contracture: a case report
Authors: Prasetyono TOH , Caroline I
Published: June 2017

A 2-year-old boy presented to the plastic and reconstructive surgery outpatient clinic with bilateral post-burn hand flexion contracture. The contracture had been released twice elsewhere. The third surgical repair on one hand at a time was conducted by the author (TOHP). However, inadeq.uate compliance to the postoperative splinting and exercise led to the recurrence of the contracture in the following year. A customised two-sided splint was therefore created to ensure proper placement and compliance. Reinforcement to the parents to encourage the boy to practise active exercise on demand was also an integral part of the management. Good functional and cosmetic outcome were presented at 1-year follow-up. This case highlights the value of a two-sided splint for the management of post-burn hand flexion contracture in children whose compliance is inevitably cannot be guaranteed.