bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of obsessive morbid jealousy with cognitive analytic therapy: An adjudicated hermeneutic single‐case efficacy design evaluation
Authors: Curling Louise , Kellett Stephen , Totterdell Peter , Parry Glenys , Hardy Gillian , Berry Katherine
Published: October 2017

Objective

The evidence base for the treatment of morbid jealousy with integrative therapies is thin. This study explored the efficacy of cognitive analytic therapy (CAT).

Design

An adjudicated hermeneutic single‐case efficacy design evaluated the cognitive analytic treatment of a patient meeting diagnostic criteria for obsessive morbid jealousy.

Method

A rich case record was developed using a matrix of nomothetic and ideographic quantitative and qualitative outcomes. This record was then debated by sceptic and affirmative research teams. Experienced psychotherapy researchers acted as judges, assessed the original case record, and heard the affirmative‐versus‐sceptic debate. Judges pronounced an opinion regarding the efficacy of the therapy.

Results

The efficacy of CAT was supported by all three judges. Each ruled that change had occurred due to the action of the therapy, beyond any level of reasonable doubt.

Conclusions

This research demonstrates the potential usefulness of CAT in treating morbid jealousy and suggests that CAT is conceptually well suited. Suggestions for future clinical and research directions are provided.

Practitioner points

The relational approach of CAT makes it a suitable therapy for morbid jealousy.

The narrative reformulation component of CAT appears to facilitate early change in chronic jealousy patterns.

It is helpful for therapists during sessions to use CAT theory to diagrammatically spell out the patterns maintaining jealousy.
The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival
Authors: Orlow Irene , Shi Yang , Kanetsky Peter A. , Thomas Nancy E. , Luo Li , Corrales‐Guerrero Sergio , Cust Anne E. , Sacchetto Lidia , Zanetti Roberto , Rosso Stefano , Armstrong Bruce K. , Dwyer Terence , Venn Alison , Gallagher Richard P. , Gruber Stephen B. , Marrett Loraine D. , Anton‐Culver Hoda , Busam Klaus , Begg Colin B. , Berwick Marianne ,   the GEM Study Group
Published: October 2017

Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3′‐end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma‐specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.
Effects of maternal separation and antidepressant drug on epigenetic regulation of the brain‐derived neurotrophic factor exon I promoter in the adult rat hippocampus
Authors: Park Sung Woo , Seo Mi Kyoung , Lee Jung Goo , Hien Le Thi , Kim Young Hoon
Published: October 2017

Aim

Early life stress can induce epigenetic changes through genetic and environmental interactions and is a risk factor for depression. Brain‐derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression and antidepressant drug action. We investigated epigenetic changes at the BDNF exon I promoter in the hippocampus of adult rats subjected to maternal separation (MS) during early life and treated with an antidepressant drug as adults.

Methods

Rat pups were subjected to MS from postnatal day 1 to 21 and received chronic escitalopram (ESC) as adults. We assessed the effects of MS and ESC on BDNF exon I and DNA methyltransferases (DNMT) mRNA levels (quantitative reverse‐transcription polymerase chain reaction), acetylated histone H3, and MeCP2 binding to the BDNF promoter I (chromatin immunoprecipitation followed by real‐time polymerase chain reaction), and BDNF protein levels (enzyme‐linked immunosorbent assay).

Results

The levels of BDNF protein, exon I mRNA, histone H3 acetylation, and DNMT1 and DNMT3a mRNA were altered in the MS group compared with the control group. Significant decreases were observed in the BDNF protein, exon I mRNA, and histone H3 acetylation levels and there were significant increases in DNMT1 and DNMT3a mRNA levels. The comparison between the MS + ESC and MS groups revealed significant increases in BDNF protein, exon I mRNA, and histone H3 acetylation levels and significant decreases in MeCP2 and DNMT1 and DNMT3a mRNA levels.

Conclusion

These findings indicate that MS induced epigenetic changes at the BDNF exon I promoter and these changes were prevented by antidepressant drug treatment during adulthood.
The complex relationship among arteriovenous access, heart, and circulation
Authors: Basile Carlo , Lomonte Carlo
Published: October 2017

There are currently near 400 000 patients on hemodialysis in the United States. More than 50% of those treated by chronic hemodialysis die because of a cardiovascular (CV) event. The majority of these patients have functional arteriovenous fistulas (AVFs). AVFs have an adverse effect on cardiac function, but their exact contribution to CV morbidity is not clear. It has long been known that a vascular access with an inappropriately high‐flow rate may cause high‐output heart failure. Paradoxically, there may be hemodynamic and cardiopulmonary benefits conferred by AVF particularly in severe chronic obstructive pulmonary disease. While Brescia‐Cimino`s basic idea of the AVF has saved millions of lives, we would like to stress that there are dangers from their often high blood flow rates, which unfortunately have proved difficult to evaluate.
What is preserved in the aeolian rock record? A Jurassic Entrada Sandstone case study at the Utah–Arizona border
Authors: Kocurek Gary , Day Mackenzie
Published: October 2017

Aeolian dune fields evolve from protodunes and small dunes into a pattern of progressively fewer, larger and more widely spaced dunes within limits defined by boundary conditions. However, the allogenic boundary conditions that promote aeolian dune‐field development, accumulation of strata and preservation of accumulated strata are not the same. Autogenic processes, such as dune interactions, scour‐depth variation along migrating dunes and substrate cannibalization by growing dunes, result in removal of the stratigraphic record. Moreover, dune‐field events may be collapsed into major erosional bounding surfaces. The question is what stages of evolving dune fields are represented in the rock record? This case study of ca 60 m of Jurassic Entrada Sandstone on the Utah/Arizona border (USA) defines stratigraphic intervals by gross architecture of bounding surfaces and sets of cross‐strata. The interpreted intervals in stratigraphic order consist of: (i) a lower sabkha bed that transitions upward into erosional remnants of small sets representing an initial wet aeolian system; (ii) large, compound cross‐strata representing a mature dune field; (iii) isolated scour‐fill representing negatively climbing dunes that produced ca 25 m of palaeo‐topographic relief; (iv) downlapping sets that fill the landscape‐scale relief; (v) four intervals of stacked climbing sets that each represent short periods of time; and (vi) an upper sabkha bed that again transitions into small sets representing a wet system. Accumulations appear to be associated with sediment pulses, a rising water table, and filling of scoured troughs and landscape‐scale depressions. Preservation of the accumulations is selective and associated with a rising water table, burial and subsidence. The preserved record appears remarkably incomplete. Speculation about missing strata gravitates towards cannibalization of the record of early dune‐field construction, and strata removed during the formation of bounding surfaces. This local Entrada record is thought to represent a point in the spectrum of preservation styles in the rock record.
Galectin‐3 is Persistently Increased in Early Rheumatoid Arthritis (RA) and Associates with Anti‐CCP Seropositivity and MRI Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity
Authors: Issa S. F. , Christensen A. F. , Lindegaard H. M. , Hetland M. L. , Hørslev‐Petersen K. , Stengaard‐Pedersen K. , Ejbjerg B. J. , Lottenburger T. , Ellingsen T. , Pedersen J. K. , Junker K. , Svendsen A. , Tarp U. , Østergaard M. , Junker P.
Published: October 2017

Galectin‐3 has been suggested as a pro‐inflammatory mediator in animal arthritis and rheumatoid arthritis (RA). We aimed to study the serum level of galectin‐3 in patients with newly diagnosed RA and associations with disease profile, Magnetic resonance imaging (MRI) findings and seromarkers of synovial matrix inflammation. One hundred and sixty DMARD naïve patients newly diagnosed with RA were included (CIMESTRA study). Clinical, serological and imaging data were recorded before treatment and at 6 weeks, 3 and 12 months. Galectin‐3 and hyaluronan (HYA) were measured by ELISA (R&D and Corgenix, USA), and the N‐terminal propeptide of type III collagen (PIIINP) by radioimmunoassay (Orion Diagnostica, Finland). One hundred and nineteen, 87 and 60 blood donors served as controls for galectin‐3, HYA and PIIINP, respectively. Baseline galectin‐3 was significantly elevated in anti‐CCP positive (4.2 μg/l IQR [3.6;6.1]) patients as compared with anti‐CCP negatives (4.0 μg/l [2.6;4.9], P = 0.05) and controls (3.8 μg/l [3.0;4.8], P < 0.01). During treatment, galectin‐3 remained elevated, but increased transiently with peak values at 6 weeks. Galectin‐3 correlated with baseline smoking, anti‐CCP, and with MRI erosion score after 1 year of follow‐up. HYA and PIIINP were elevated (P < 0.001) irrespective of anti‐CCP status and correlated positively with synovitis assessed clinically and by MRI. HYA and PIIINP did not correlate with galectin‐3. These observations indicate that HYA and PIIINP mainly reflect expansive synovitis proliferation while galectin‐3 is more closely linked to autoimmunity, smoking and joint destructive processes.
When the Going Gets Tough: Issue Environments and Gendered Negativity Strategies*
Authors: Nelson Kjersten
Published: October 2017

Objective

In theory, gender expectations may influence candidate's negativity strategies. However, these gender expectations interact with other factors, such as party expectations and the election's issue environment. This study seeks to determine if candidate gender, opponent gender, and issue environment affect negativity strategies.

Methods

The study analyzes the ads purchased by U.S. congressional candidates in the 2004 and 2008 election cycles.

Results

The analyses show that gender and party expectations, moderated by the issue environment of the election, affect levels of negativity. Democratic women and Republican men appear to be particularly sensitive to these contextual changes.

Conclusion

The results bolster other findings that gender expectations are moderated by party expectations, as well as context dependent. In addition, given that women report more reluctance to run for office based on the potential of being involved in a negative campaign, the results provide insight as to why more women are not running for office.
Comparative analyses of industrial‐scale human platelet lysate preparations
Authors: Pierce Jan , Benedetti Eric , Preslar Amber , Jacobson Pam , Jin Ping , Stroncek David F. , Reems Jo‐Anna
Published: October 2017

BACKGROUND

Efforts are underway to eliminate fetal bovine serum from mammalian cell cultures for clinical use. An emerging, viable replacement option for fetal bovine serum is human platelet lysate (PL) as either a plasma‐based or serum‐based product.

STUDY DESIGN AND METHODS

Nine industrial‐scale, serum‐based PL manufacturing runs (i.e., lots) were performed, consisting of an average ± standard deviation volume of 24.6 ± 2.2 liters of pooled, platelet‐rich plasma units that were obtained from apheresis donors. Manufactured lots were compared by evaluating various biochemical and functional test results. Comprehensive cytokine profiles of PL lots and product stability tests were performed. Global gene expression profiles of mesenchymal stromal cells (MSCs) cultured with plasma‐based or serum‐based PL were compared to MSCs cultured with fetal bovine serum.

RESULTS

Electrolyte and protein levels were relatively consistent among all serum‐based PL lots, with only slight variations in glucose and calcium levels. All nine lots were as good as or better than fetal bovine serum in expanding MSCs. Serum‐based PL stored at −80°C remained stable over 2 years. Quantitative cytokine arrays showed similarities as well as dissimilarities in the proteins present in serum‐based PL. Greater differences in MSC gene expression profiles were attributable to the starting cell source rather than with the use of either PL or fetal bovine serum as a culture supplement.

CONCLUSION

Using a large‐scale, standardized method, lot‐to‐lot variations were noted for industrial‐scale preparations of serum‐based PL products. However, all lots performed as well as or better than fetal bovine serum in supporting MSC growth. Together, these data indicate that off‐the‐shelf PL is a feasible substitute for fetal bovine serum in MSC cultures.
Evaluation of reticulocyte hemoglobin content (RET‐He) in the diagnosis of iron‐deficient erythropoiesis in dogs
Authors: Fuchs Jannika , Moritz Andreas , Grußendorf Esther , Lechner Jörg , Neuerer Felix , Nickel Rafael , Rieker Thomas , Schwedes Claudia , DeNicola Dennis B. , Russell James , Bauer Natali
Published: October 2017

Background

Reticulocyte hemoglobin content provided by the Siemens ADVIA (CHr) is an established marker of iron deficiency. TheIDEXXProCyte Dx hematology analyzer now provides a similar variable, reticulocyte hemoglobin equivalent (RET‐He).

Objectives

The objective was to evaluateRET‐Heand its diagnostic utility in dogs, and to calculate a cutoff value for diagnosing iron‐deficient erythropoiesis (IDE). Furthermore, the prevalence ofRET‐Hevalues below this cutoff value was established.

Methods

One hundred and seventy‐one CBCs of healthy dogs were used to establish aRI. Stability ofRET‐Hewas evaluated by repeated measurements over 48 hours (n= 10). The 25‐run coefficient of variation (CV) was calculated, and correlation and bias between measurements ofRET‐HeandCHr were assessed (n= 190). A cutoff value for diagnosingIDEwas calculated. The utility ofRET‐Hein the detection ofIDEwas evaluated in 123 dogs. The prevalence of lowRET‐Hevalues was assessed retrospectively in a multicenter study (2012–2014) under participation of 7 veterinary clinics.

Results

Reticulocyte hemoglobin equivalent with anRIof 22.2 to 28.6 pg was statistically stable over 48 hours (P= .10). TheCVwas 1.8%. A fair correlation (ρ = 0.74) betweenRET‐HeandCHr with a small bias of −0.6 pg was found. The cutoff value for diagnosingIDEwas 20.9 pg (sensitivity: 85%; specificity: 99%). The prevalence ofRET‐Hevalues below 20.9 pg was 10.3% (1084/10,553 dogs).

Conclusions

RET‐Heon the ProCyte Dx is a precise screening tool in dogs to detect iron‐deficient erythropoiesis.
Correlation between plasma fibrinogen and FIBTEM thromboelastometry during liver transplantation: a comprehensive assessment
Authors: Blasi A. , Sabate A. , Beltran J. , Costa M. , Reyes R. , Torres F.
Published: October 2017

Background

Thromboelastometry may reduce red blood cell (RBC) transfusion in liver transplantation (LT). Fibrinogen concentration is a primary determinant of FIBTEM maximum clot firmness (MCF), but several factors could affect the correlation between FIBTEM MCF and fibrinogen values. We aimed to investigate (1) the concordance between fibrinogen level and FIBTEM MCF and (2) the association of fibrinogen level and FIBTEM MCF with RBC transfusion during LT.

Methods

A post hoc analysis of data from a randomized, multicentre, double‐blind, saline/fibrinogen trial was used (NCT01539057). A total of 86 adult patients were included.

Results

The Lin concordance coefficient (LCC) between FIBTEM MCF and fibrinogen levels with the model formula 1·3679 + 0·05414* FIBTEM MCF was poor overall (LLC [95% CI]: 0·387 [0·340 to 0·432]) and moderate for the preperfusion period (LLC [95% CI]: 0·789 [0·747 to 0·824]), but very poor for the postreperfusion period (LLC [95% CI] 0·170 [0·105 to 0·233]). The model assessed for RBC transfusion for FIBTEM MCF showed an area under the curve of 0·788 [0·745‐0·832]. Patients with FIBTEM MCF values <8 mm had a significantly higher likelihood of receiving RBC than patients with higher values. (OR [95% CI]: 2·08 [1·30‐3·33], P = 0·002). FIBTEM MCF values over 10 mm do not appear to reduce the likelihood of RBC transfusion.

Conclusion

FIBTEM MCF is not a good indicator of plasma fibrinogen values after graft reperfusion. FIBTEM MCF >8 mm during the LT procedure is associated with less RBC transfusion. FIBTEM MCF values over 10 mm could lead to unnecessary fibrinogen administration.
Comparison of 2 training programs for basic laparoscopic skills and simulated surgery performance in veterinary students
Authors: Chen Chi‐Ya , Ragle Claude A. , Lencioni Rachael , Fransson Boel A.
Published: October 2017

Objective

To compare the effects of 2 training curricula on laparoscopic skills and performance of simulated surgery in veterinary students.

Study design

Prospective study.

Sample population

Veterinary students (n = 33) with no prior hands‐on experience in minimally invasive surgery.

Methods

Basic laparoscopic skills (BLS) were assessed based on 5 modified McGill inanimate system for training and evaluation of laparoscopic skills. Motion metrics and an objective structured assessment of technical skills (OSATS) were used to evaluate surgical skills during a simulated laparoscopic cholecystectomy performed in an augmented reality simulator. Students were randomly assigned to either skill‐based (group A) or procedural‐based (group B) training curriculum. Both tests were performed prior to and after a 10‐session training curriculum.

Results

Post‐training BLS results were improved in both training groups (P < .001). Seven participants completed both presimulated and postsimulated laparoscopic cholecystectomy, preventing paired analysis. Based on motion metrics analysis, participants completed tasks in a shorter time (P = .0187), and with better economy of movement (P = .0457) after training. No difference was detected in OSATS before and after training.

Conclusion

Both training curricula improved BLS, but significant differences were not detected between the procedural‐based training program and basic skills training alone in veterinary students. Motion metrics such as time, economy of movement, and instrument path were superior to an OSATS, when assessing surgical performance. Further studies are needed to compare the effects of different simulators on the training of veterinarians with diverse laparoscopic surgical experience.
Nearby cycles of automorphic étale sheaves
Authors: Lan Kai-Wen , Stroh Benoît
Published: October 2017

We show that the automorphic étale cohomology of a (possibly noncompact) PEL-type or Hodge-type Shimura variety in characteristic zero is canonically isomorphic to the cohomology of the associated nearby cycles over most of their mixed characteristics models constructed in the literature.
Tick infestation in bank voles from East Anglia
Authors: De MENDONCA Philippe Gil
Published: October 2017

Bank voles (Clethrionomys glareolus) are widespread and abundant in the western half of Eurasia, including Great Britain. These small rodents often come into contact with domestic animals and/or humans, either directly or indirectly, and thus are an interface between sylvatic and domestic cycles for zoonotic organisms. Bank voles were live-trapped and inspected for ticks in Cambridgeshire, Essex and Suffolk from June 1999 to April 2000. Infested voles hosted between 1 and 10 ticks. Larvae were the most frequent stage. Overall prevalence estimate of tick infestation was 14.5% (95% C.I. : 8.3% to 20.7%). Prevalence estimates fluctuated with seasons. Two tick species were identified : Ixodes ricinus (larvae only) and Ixodes trianguliceps (all three stages). The aggregated distribution of ticks on their hosts suggests that co-feeding transmission of tick-borne pathogens may happen in British bank voles. Further investigations are required to improve our knowledge and understanding of the epidemiology of tick-borne diseases in East Anglia.
Additional information on ticks (Ixodidae) infesting birds in Atlantic Forest fragments in State of Paraná, South Brazil
Authors: Luz Hermes Ribeiro , Morgana Honara , Martins Thiago F. , Pichorim Mauro , Labruna Marcelo B. , Faccini João L. Horacio
Published: October 2017

Wild birds have an important role in the epidemiology of tick-borne diseases, serving as reservoirs for some tick-borne diseases and in the maintenance and dispersion of ticks. During the years of 1999, 2000 and 2001, birds were captured in three Atlantic forest fragments of the state of Paraná. Overall, 1,122 bird specimens of 36 species were captured. Of these, 80 (7.1% prevalence) birds were parasitized by ticks, comprising females of Ixodes paranaensis Barros-Battesti, Arzua, Pichorim & Keirans, and immature stages of Amblyomma calcaratum Neumann, Amblyomma longirostre (Koch), Amblyomma aureolatum (Pallas), Amblyomma ovale Koch, and Amblyomma parkeri Fonseca & Aragão. Two nymphs were identified as Amblyomma sp., although their external morphology was very similar to the A. parkeri nymph. This study provides new tick-host records for the state of Paraná and for Brazil.
Revision of the family Carabodidae (Acari: Oribatida) XIII. Congocepheus camerunensis sp. nov. from Cameroon and Synkrotima zimbabwae gen. nov., sp. nov. from the Republic of Zimbabwe
Authors: Fernandez Nestor , Theron Pieter Daniel , Leiva Sergio , Tiedt Louwrens
Published: October 2017

Congocepheus camerunensis sp. nov. from Cameroon and Synkrotima zimbabwae gen. nov., sp. nov. from Zimbabwe are described using optical and Scanning Electron Microscopy (SEM). Congocepheus camerunensis is similar to C. heterotrichus, differentiated by: dissimilarity in shape and length of prodorsal, notogastral, epimeral, agenital, and adanal setae; placement, shape, and size of finger-like projection, bothridial ring and tutorium. Synkrotima zimbabwae gen. nov., sp. nov. is a distinctive species with a more or less flat elevated interlamellar process with longitudinal elevations and an anterior expansion; very complex ventral ornamentations with alternating depressed and elevated zones; genital neotrichy; absence of notogastral depression; the differences in shape and lengths of the prodorsal, notogastral, epimeral, genital, aggenital, adanal and anal setae in comparison to other species of the family Carabodidae.
Fabrication of nickel stamp using e-beam evaporation and electroforming for electroreduction of carbon dioxide
Authors: Lan Yangchun , Zhuge Wuyang , Cui Dehu , Cheng Xing
Published: October 2017

Electronic properties and electroanalytical behaviors are highly dependent on the morphologies of electrodes. Thus, many techniques are continuously developed to enhance carrier mobility by promoting the ordered packing of electrodes. In this work, the authors investigated the electroanalytical behavior of different prepared electrodes by controlling the morphologies of the electrodes through semiconductor-manufacturing techniques. A nickel stamp was fabricated by using photolithography, inductively coupled plasma etching, e-beam evaporation, and the electroforming technique. The stamp was used as an electrochemical electrode in a standard three-electrode cell in aqueous solution, thereby revealing the relationships among the microstructure, nickel stamp, and zinc oxide as a function of applied potential. The electrochemical reduction reaction was carried out in a conventional reactor in the presence of carbon dioxide. This reaction exhibited a higher faradaic efficiency for carbon monoxide and methane than that observed when flat nickel electrodes were used.
A noncommutative generalization of Thurston’s gluing equations
Authors: Morvan Xavier
Published: October 2017

In his famous Princeton Notes, Thurston introduced the so-called gluing equations defining the deformation variety. Later, Kashaev defined a noncommutative ring from H-triangulations of 3-manifolds and observed that for trefoil and figure-eight knot complements the abelianization of this ring is isomorphic to the ring of regular functions on the deformation variety, Kashaev, [Formula: see text]-groupoids in knot theory, Geom. Dedicata 150(1) (2010) 105–130; Kashaev, Noncommutative teichmüller spaces and deformation varieties of knot completeness; Kashaev, Delta-groupoids and ideal triangulation in Chern–Simons gauge theory: 20 Years After, AMS/IP Studies Advanced Mathematics, Vol. 50 (American Mathematical Society, RI, 2011). In this paper, we prove that this is true for any knot complement in a homology sphere. We also analyze some examples on other manifolds.
Gravitational-wave observations from ground-based detectors
Authors: Li Tjonnie G. F.
Published: October 2017

Recent detections of gravitational waves by the LIGO detectors herald a new era of observational astronomy. Previously invisible objects and phenomena may now be uncovered through their gravitational interaction. Observation of gravitational waves allows one to explore the extremes of the Universe and study astronomy and fundamental physics like never before. This article gives a brief overview of the detection process, from the production of the data to their physical implications.
Some non-local logistic population model with non-zero boundary condition
Authors: Cerda Patricio , Souto Marco , Ubilla Pedro
Published: October 2017

In this paper, we study some type of equations which may model the behavior of species inhabiting in some habitat. For our purpose, using a priori bounded techniques, we obtain a positive solution to a family of non-local partial differential equations with non-homogeneous boundary conditions.
Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems
Authors: Magdy Tarek , Schuldt Adam J.T. , Wu Joseph C. , Bernstein Daniel , Burridge Paul W.
Published: October 2017

Billions of US dollars are invested every year by the pharmaceutical industry in drug development, with the aim of introducing new drugs that are effective and have minimal side effects. Thirty percent of in-pipeline drugs are excluded in an early phase of preclinical and clinical screening owing to cardiovascular safety concerns, and several lead molecules that pass the early safety screening make it to market but are later withdrawn owing to severe cardiac side effects. Although the current drug safety screening methodologies can identify some cardiotoxic drug candidates, they cannot accurately represent the human heart in many aspects, including genomics, transcriptomics, and patient- or population-specific cardiotoxicity. Despite some limitations, human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) are a powerful and evolving technology that has been shown to recapitulate many attributes of human cardiomyocytes and their drug responses. In this review, we discuss the potential impact of the inclusion of the hiPSC-CM platform in premarket candidate drug screening
Joint Optimization of Interference and Cost in Cognitive Radio Heterogeneous Network Using Fuzzy Logic Powered Ants
Authors: Latif Shahzad , Akraam Suhail , Saleem Muhammad Aamer
Published: October 2017

The advent of emerging wireless technologies has increased the demand of spectrum resources. On the other hand, present spectrum assignment is fixed and underutilized. Cognitive radio (CR) provides good solution to spectrum scarcity problem to accommodate new wireless applications. The network selection is an important mechanism in cognitive radio heterogeneous network (CRHN) to provide optimal Quality of Service (QoS) to both Primary Users (PUs) and Secondary Users (SUs). The aim of this work is to provide optimal QoS to SUs by appropriate network selection and channel assignment. The proposed FLACSA selects the best network while maximizing the data rate and minimizing the interference and cost simultaneously. Simulation results show the attractive performance of our proposed algorithm.
Posttraumatic Psychiatric Disorders and Resilience in Healthcare Providers following a Disastrous Earthquake: An Interventional Study in Taiwan
Authors: Ke Ya-Ting , Chen Hsiu-Chin , Lin Chien-Ho , Kuo Wen-Fu , Peng An-Chi , Hsu Chien-Chin , Huang Chien-Cheng , Lin Hung-Jung
Published: October 2017

Background. Posttraumatic psychiatric disorders (PTPDs) are common in disaster workers; however, their incidence and resilience in healthcare providers (HCPs) following a disastrous earthquake are still unclear. Therefore, we conducted an interventional study to clarify this issue. Methods. After a medical response to the scene of a collapsed huge building, we conducted an assessment of the HCPs using an immediate self-administered questionnaire and a follow-up questionnaire 1 month later. Psychological support after the operation was implemented. We performed analysis of the risk for PTPDs and comparison between immediate and follow-up questionnaires. Results. The mean age (standard deviation) of the HCPs was 32.7 (5.2) years, with 33.5 (5.8) years for nurses and 32.4 (4.4) years for physicians. The proportion of females among the nurses and physicians was 94.3% and 12.5%, respectively. In total, 16.4% (11/67) of HCPs fit the criteria of PTPDs. Nurses had a trend of higher incidence than physicians. Female HCPs had a trend of higher incidence than male HCPs. After intervention, none of the HCPs reported PTPDs in the follow-up questionnaire (p<0.05). Conclusion. This study delineated that PTPDs were common in HCPs following medical response to an earthquake; however, the resilience was good after the early intervention.
A New Calculation Method for the Soil Slope Safety Factor
Authors: Zhu Fu , Zhang Wanxi , Sun Mingzhi
Published: October 2017

Based on the unified strength theory, a new method to calculate the plane soil slope safety factor was derived that considers the effect of intermediate principal stress σ2 and at‐rest lateral pressure coefficient K0. Calculation examples from the literature were used to compare the new calculation method and the current slice method; the results showed that both provided good consistency. The new method can provide a reference for slope stability evaluation. The new method was used to calculate the soil slope safety factors for different values of intermediate principal stress parameter b, double shear stress parameters , and static lateral pressure coefficient K0. The results showed that the safety factor Fs increased when b was increased; Fs first increased and then decreased when was increased; and Fs increased when K0 was increased. These results show that the intermediate principal stress as well as the stress state and its changes cannot be ignored during soil slope stability analysis. The slope soil characteristics and stress state should be considered to determine the unified strength theoretical parameters and static lateral pressure coefficient, maximize the potential of slope soil strength, and effectively reduce the costs of soil slope engineering.
Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft
Authors: Alharbi Abdullah , Al Turki Maram S. , Aloudah Noura , Alsaad Khaled O.
Published: October 2017

The incidence of renal cell carcinoma (RCC) in renal allograft in transplant recipients is 0.22–0.25%. De novo clear cell, papillary, and chromophobe RCCs and RCCs with sarcomatoid differentiation originating in renal allograft have been reported. Routine surveillance for graft tumours is not routinely practiced and these tumours are commonly asymptomatic and incidentally discovered. We describe a case of incidental, eosinophilic chromophobe RCC in a 31-year-old, long-term renal transplant male recipient, who presented with acute gastroenteritis 11 years after transplantation. The graft was nonfunctional at the time of presentation. Abdominal ultrasound and computed tomography scan demonstrated 1.8 cm well-defined, round enhancing lesion, confined to the renal allograft and suspicious for malignancy. Pathological examination of graft nephrectomy specimen showed gross, histopathological, and immunohistochemical features of eosinophilic chromophobe RCC. Fifty-five months after surgery, the patient was alive and free of malignancy. To the best of our knowledge, only five chromophobe RCCs originating in a renal allograft were previously described in English literature. We suggest that chromophobe RCC should be considered in the differential diagnosis of renal allograft mass, including eosinophilic tumours, and emphasise the importance of periodic screening of renal allograft in all renal transplant recipients.
Analgesic Effect of Moxibustion with Different Temperature on Inflammatory and Neuropathic Pain Mice: A Comparative Study
Authors: Zhou Wei , Lei Ruxue , Zuo Chuanyi , Yue Yunqing , Luo Qin , Zhang Chengshun , Lv Peng , Tang Yong , Yin Haiyan , Yu Shuguang
Published: October 2017

The aim of this study was to determine whether variation of temperature during moxibustion would generate division of analgesic effect. The moxibustion with different temperatures (37°C, 42°C, 47°C, and 52°C) was applied to ST36 acupoint for 30 minutes in chronic inflammatory or neuropathic pain mice. The analgesic effect was evaluated by thermal hyperalgesia test in chronic inflammatory pain and by mechanical allodynia in neuropathic pain, respectively. The results indicated that interventions of moxibustion with different temperature caused different analgesic effect on either chronic inflammatory induced by injection of complete Freund’s adjuvant (CFA) or neuropathic pain induced by spared nerve injury (SNI). In chronic inflammatory pain, different moxibustion temperature generated different intensity of analgesic effect: the higher the better. In chronic neuropathic pain, stronger analgesic effect was found in moxibustion with temperature 47°C or 52°C other than 37°C and 42°C. However, there is no significant difference displayed between moxibustion temperatures 47°C and 52°C or 37°C and 42°C. It implies that the temperature should be taken into account for moxibustion treatment to chronic inflammatory or neuropathic pain.
Singular Integral Equations of Convolution Type with Cosecant Kernels and Periodic Coefficients
Authors: Li Pingrun
Published: October 2017

We study singular integral equations of convolution type with cosecant kernels and periodic coefficients in class L2[−π, π]. Such equations are transformed into a discrete jump problem or a discrete system of linear algebraic equations by using discrete Fourier transform. The conditions of Noethericity and the explicit solutions are obtained by means of the theory of classical boundary value problem and of the Fourier analysis theory. This paper will be of great significance for the study of improving and developing complex analysis, integral equations, and boundary value problems.
Modulation Classification Based on Extensible Neural Networks
Authors: Qing Yang Guan
Published: October 2017

A deep learning architecture based on Extensible Neural Networks is proposed for modulation classification in multipath fading channel. Expanded Neural Networks (ENN) are established based on energy natural logarithm model. The model is set up using hidden layers. Modulation classification based on ENN is implemented through the amplitude, phase, and frequency hidden network, respectively. In order to improve Probability of Correct classification (PCC), one or more communication signal features are extracted using hidden networks. Through theoretical proof, ENN learning network is demonstrated to be effective in improving PCC using amplitude, phase, and the frequency weight subnetwork, respectively. Compared with the traditional algorithms, the simulation results show that the proposed ENN has higher PCC than traditional algorithm for modulation classification within the same training sequence and Signal to Noise Ratio (SNR).
Spontaneous Bilateral Sternoclavicular Joint Septic Arthritis and Lumbar Discitis: An Unusual Case in a Healthy Adult
Authors: Mamarelis Georgios , Sohail Mohammad Zain , Mamarelis Athanasios , Fawi Hassan , Mahaluxmivala Jehangir
Published: October 2017

Introduction. Septic arthritis of the sternoclavicular (SC) joint is a rare condition. Typically, it presents in patients with risk of infection and is usually unilateral. In this report, we describe a case of spontaneous bilateral sternoclavicular joint infection of an otherwise healthy adult. Case Presentation. A 67-year-old man presented in our hospital complaining of 2-week history of neck and chest pain which was radiating to his shoulders bilaterally. Clinical examination revealed erythema and swelling of the sternoclavicular area. Inflammatory markers were raised. Image investigation with CT and MRI was undertaken and verified the presence of bilateral sternoclavicular joint infection. The patient received prolonged course of intravenous antibiotics since his admission. The patient was discharged in a good condition and followed up in clinic. Conclusion. High index of clinical suspicion of SC joint infection is important for early diagnosis to avoid further complications.
The Effect of Pterygomasseteric Sling’s Area in the Postoperative Stability after Mandibular Setback Surgery
Authors: Chen Chun-Ming , Ting Chun-Chan , Cheng Jung-Hsuan , Hsu Kun-Jung , Tseng Yu-Chuan
Published: October 2017

Purpose. The purpose of the present study was to investigate the correlation between the postoperative stability and area of pterygomasseteric sling (PMS). Materials and Methods. Forty patients of mandibular prognathism were treated by isolated mandibular setback. Serial lateral cephalograms were collected (preoperatively [T1], immediately after surgery [T2], and more than 1 year postoperatively [T3]). The postoperative stability (T32) was divided into 3 groups (total, forward, and backward movements). The areas of PMS, immediate surgical changes (T21), postoperative stability (T32), and final surgical change (T31) were analyzed by Student’s t-test, Pearson’s correlation coefficient, and multiple linear regression analysis. Results. The amount of mean setback (T21) was 12.6 mm in total group, 13.8 mm in forward group, and 10.8 mm in backward group. In the total group, postoperative stability (T32) was 0.6 mm forward and reduction area of PMS (T31) was 291 mm2 (17.2%). The reduction area of PMS (T31) was 298.2 mm2 (18%) and 263.1 (15.3%) mm2 in the forward group (3 mm) and backward group (2.4 mm), respectively. However, reduction area of PMS (T31) showed weak correlation with postoperative stability (T32) in all groups. Conclusion. Total and forward groups presented significant correlations between postoperative stability (T32) and amount of setback (T21).
Impact of Scalar Leptoquarks on Heavy Baryonic Decays
Authors: Azizi K. , Olgun A. T. , Tavukoğlu Z.
Published: October 2017

We present a study on the impact of scalar leptoquarks on the semileptonic decays of Λb, Σb, and Ξb. To this end, we calculate the differential branching ratio and lepton forward-backward asymmetry defining the processes Λb→Λl+l-, Σb→Σl+l-, and Ξb→Ξl+l-, with l being μ or τ, using the form factors calculated via light cone QCD in full theory. In calculations, the errors of form factors are taken into account. We compare the results obtained in leptoquark model with those of the standard model as well as the existing lattice QCD predictions and experimental data.
Association of ABO Blood Types and Clinicopathological Features of Prostate Cancer
Authors: Wang Fang-Ming , Zhang Yan , Zhang Gui-Ming , Liu Ya-Nan , Sun Li-Jiang , Liu Yong
Published: October 2017

Purpose. To investigate the association between ABO blood types and clinicopathological characteristics in patients with prostate cancer (PC). Methods. A total of 237 pathologically diagnosed PC patients were enrolled. All patients were classified as low–middle or high-risk group. The correlation of ABO blood types with high-risk PC was determined by univariate and multivariate regression analysis. Results. Data indicated 144 (85.7%) patients were stratified as high risk in the non-O group, while 50 (72.5%) patients in the O group (p=0.025). However, there was no significant difference regarding PSA, Gleason score, stage, or metastasis between O and non-O group (p>0.05). Univariate logistic regression analyses revealed PSA, Gleason score, and blood type non-O were all correlated with high-risk PC (OR = 1.139, p<0.001; OR = 9.465, p<0.001; OR = 2.280, p=0.018, resp.). In the stepwise multivariate regression analysis, the association between blood type non-O and high-risk PC remained significant (OR = 33.066, 95% CI 2.391–457.323, and p=0.009) after adjusting for confounding factors as well as PSA and Gleason score. Conclusion. The present study firstly demonstrated that non-O blood type was at higher risk of aggressive PC compared with O type, suggesting that PC patients with non-O blood type should receive more attention in clinical practice.
Frequency-Hopping Transmitter Fingerprint Feature Classification Based on Kernel Collaborative Representation Classifier
Authors: Sui Ping , Guo Ying , Zhang Kun-feng , Li Honguang
Published: October 2017

Noncooperation frequency-hopping (FH) transmitter fingerprint feature classification is a significant but challenging issue for FH transmitter recognition, since not only is it sensitive to noise but also it has the nonlinear, non-Gaussian and nonstability characteristics, which make it difficult to guarantee the classification in the original signal space. To address these problems, a method of frequency-hopping transmitter fingerprint feature classification based on kernel collaborative representation classifier is proposed in this paper. First, the noise suppression pretreatment of the FH transmitter signal is carried out by using the wave atoms frame method. Then, the nuances of the FH transmitters in the feature space are characterized by the surrounding-line integral bispectra features. And finally, incorporating the kernel function, a classifier which can generalize a linear algorithm to nonlinear counterpart is constructed for the final transmitter fingerprint feature classification. Extensive experiments on real-world FH transmitter “turn-on” transient signals demonstrate the robust classification of our method.
Successful Pelvic Resection for Acetabular Hydatidosis
Authors: Daniel Canoville , Matthieu Hannebicque , Goulven Rochcongar , Jocelyn Michon , Valérie Dumaine , Christophe Hulet
Published: October 2017

Background. Hydatidosis of the bone is a rare occurrence (0.9 to 2.5% of all localization of the disease). In those occurrences, the pelvic bone is the second most frequent localization. Curative treatment of pelvic bone hydatidosis is difficult and a consensus is yet to be found. Clinical Case. We report a case of hydatidosis of the ischium, extended to the homolateral hip. The patient was treated through hip resection using patient-specific cutting guides, followed by total hip reconstruction. Albendazole was administered to the patient for two months before the surgery and for three months following the surgery. Conclusions. In a young patient, hydatidosis of the pelvic bone can be treated with satisfying results through wide resection of the hip coupled with an antiparasitic treatment administered before and after the surgery. Prosthetic reconstruction, similar to what is done in cancer surgery, restores good functions.
Перспективність надання гігієністом зубним профілактичної стоматологічної допомоги населенню м. Житомира
Authors: Kosenko V. M. , Chepiuk S. M.
Published: October 2017

Preventive medicine is the basis for the development of health care systems in the European Union, and investment in prevention is recognized as the most effective investment in the industry of preserving and improving health. Prophylactic direction – one of the most important in modern dentistry.The aim of the study – analysis of treatment and prevention performance indicators of Municipal Institution Zhytomyr City Dental Hospital No.1 and defi nition of methods for improving the primary prevention.Materials and Methods. We analyzed the annual reports of internal medicine and surgical departments of Zhytomyr City Dental Hospital No. 1 for the period from 2015 till 2016; we held a poll of 115 patients of the establishment regarding the methods for teeth cleaning and using the accessories and means necessary for oral cavity care. The following methods were used: bibliosemantic, system analysis and logical concluding,interview, and mathematical processing of the collected data. Results and Discussion. Numeric materials refl ecting the work of Zhytomyr City Dental Hospital No.1 indicate that doctors employed in the establishment conduct numerous maneuvers related to oral cavity sanitation using modern fi lling materials and diagnostic methods. However (and predominantly), all the work is directed at secondary prevention. As a result, annually a lot of teeth are removed due to complex caries (23.370–23.898), and there are a lot of patients with signs of periodontal diseases (3.521–3.766). Dispensary for diseases includes 94 patients with pre-tumor pathology. Considering that public hygienic teaching and education is one of the main components of primary treatment, we held a poll involving 115 patients of Zhytomyr City Dental Hospital No. 1. Study results indicate that the patients of the dental care entity have insuffi cient knowledge on using the accessories and means necessary for hygienic procedures. All the respondents are more ready to invest into prevention care than internal medicine and surgical dental treatment. It is possible to reach an upward trend in dental health indicators only with primary caries and periodontal diseases prevention. Adding hygienist in the staffi ng list of dental care entities would allow not only for comprehensive primary prevention, but would also unload the high-class dentists enabling them to conduct more complex oral cavity operations.Conclusions. Zhytomyr City Dental Hospital No. 1 employs no hygienists, that is why its work is aimed at secondary treatment of oral cavity diseases. Low sanitary culture level of Zhytomyr residents is tightly connected with dental health indicators. Further development and reforming of dental care demands training of the new generation of highly qualifi ed junior medical staff (hygienists). Involving of hygienists in treatment care allows improving the quality of preventive dental services and decreasing dental diseases incidence rate.