bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of survival rates and evaluation of prognostic factors in patients with lung metastases from renal cell carcinoma
Authors: Semyonov D. V. , Orlova R. V. , Shirokorad V. I. , Kostritsky S. V. , Karlova N. A.
Published: May 2024

In patients with lung metastases from renal cell cancer (RCC), it is necessary to search for new prognostic factors influencing survival rates. Aim: To analyze survival rates and identify prognostic factors in patients with lung metastases from RCC. Material and methods. We retrospectively analyzed the data from 655 patients with lung metastases from RCC, who were treated at Moscow city oncology Hospital No. 62 (Moscow) and city clinical oncology center (Saint Petersburg) from 2006 to 2022. Of these patients, 241 (36.8 %) were classified into the intermediate prognosis group, and 278 (42.2 %) into the unfavorable prognosis group. The study investigated clinical and morphologic prognostic factors influencing survival rates in patients with lung metastases from RCC. Statistical analysis was performed using Statistica 10.0 software packages (StatSoft, USA) by constructing Kaplan-Meier curves and survival tables, building a mathematical model of survival. Results. The 3- and 5-year OS rates in patients with lung metastases from RCC (N=655) were 48 % [95 % ci 45–53 %] and 27 % [95 % ci 23–31 %], respectively, with a median OS of 34.9 months [95 % ci 30.4–37.4]. in univariate analysis, ECOG status (p<0.001), histological subtype (p<0.001), Fuhrman grade of tumor differentiation (p<0.001), type and number of metastases (p<0.001), metastases to the bones and liver (p<0.001), lymph nodes (p=0.001), prognosis according to IMDC(p<0.001), nephrectomy and metastasectomy (p<0.001) had a negative impact on OS in patients with lung metastases from RCC. In multivariate analysis, ECOG status 3.66 (2.10–6.39, p<0.001), histological subtype 1.49 (1.10–2.01, p=0.009), grade of tumor differentiation according to Fuhrman 1.54 (1.13–2.09, p=0.006), number of metastases 3.63 (1.44–9.16, p=0.006), prognosis according to IMDC2.27 (1.63–3.17, p<0.001), and nephrectomy 1.87 (1.29–2.70, p=0.001) and metastasectomy 0.69 (0.53–0.88, p=0.003) were additional factors influencing OS rates in patients with lung metastases from RCC. Conclusion. In our study, ECOG status, histologic subtype of RCC, Fuhrman grade of tumor differentiation, number of metastases, IMDC prognosis, and nephrectomy and metastasectomy were additional independent prognostic factors affecting OS in patients with lung metastases from RCC. Further studies are needed to investigate prognostic factors in patients with RCC lung metastases to improve the effectiveness of personalized treatment and survival rates.
Bioimpedance and upper limb lymphedema index in the diagnosis of lymphedema in post-mastectomy syndrome
Authors: Baytinger V. F. , Samoilova Yu. G. , Kurochkina O. S. , Magay Yu. V. , Oleinik O. A. , Altukhova A. V. , Damdinova Ia. O.
Published: May 2024

Methods for assessing post-mastectomy edema: bioimpedance and upper extremity lymphedema index (UEL index) are non-invasive, highly sensitive and easily feasible diagnostic methods, suitable for predicting the prospects of surgical treatment and analyzing the dynamics of edema. The purpose of the study was to study UEL index indicators and bioimpedance data at different stages of upper extremity lymphedema. Material and methods. The study included 64 patients with post-mastectomy edema who underwent bioimpedance, measurement of the circumference of the upper extremity and calculation of the UEL index. Results. The upper extremity lymphedema index and bioimpedance parameters (fluid volume in the limb and the ratio of extracellular fluid to total fluid volume) characterizing the liquid component significantly increased at stages II and III of lymphedema in comparison with the control group. a statistically significant correlation was revealed between the upper limb lymphedema index and bioimpedance parameters (R=0.41) and (R=0.49), respectively. Conclusion. Bioimpedance parameters and values of the upper extremity lymphedema index can be interchangeable. The reliability and high sensitivity of these methods for assessing post-mastectomy edema allows us to obtain quantitative criteria for evaluating the liquid component at different stages of lymphedema.
Proton therapy in pediatric neuro-oncology. Potential advantages and the relationship between cost and results
Authors: Regentova O. S. , Shcherbenko O. I. , Kumirova E. V. , Antonenko F. F. , Solodkiy V. A.
Published: May 2024

The aim of study: to analyze the accumulated experience and try to identify those clinical situations in which the use of protons will be economically and clinically more effective than photon radiation therapy. Material and methods. The articles devoted to the study of the evaluation and comparison of the effectiveness of proton and photon radiation beams in the treatment of tumors of the central nervous system and published over the past 25 years were searched in the Medline, Embase and the Cochrane Library databases. Results. the analysis of available publications has shown that accelerated protons do not improve survival rates and disease-free rates in all forms of brain tumors compared with photon therapy. However, protons can significantly increase the level of dose distribution conformity and reduce the dose to critical structures (pituitary gland, cochlea, eye lenses, hypothalamus), thus reducing the risk of hearing and visual impairment as well as hormonal and cognitive disorders. All this is critically important for potentially curable malignant tumors, such as medulloblastoma and germinoma, for low malignant potential tumors (grade 1–2 glioma) or tumors with decreased metastatic potential, since proton therapy compared to photon therapy reduces the risk of late side effects that worsen the quality of life of cured children. Conclusion. central nervous system tumors are one of the most common solid malignant neoplasms in children. Radiation therapy (RT) is recognized as an important therapeutic component of treatment and is often used in strategies for multimodal therapy of tumors of the central nervous system in children. Proton radiation therapy is one of the attractive methods of radiotherapy with minimal dose distribution to normal tissues and a decrease in the absorbed dose. The precision of protons reduces the risk of long-term side effects associated with this type of treatment and the induction of secondary malignancies, which is of particular importance for the quality of life.
Pengarah Citra Kota Malang sebagai Kota Kolonial melalui Metode Serial Vision
Authors: Rondonuwu Yesaya Moses , Wahjutami Erlina Laksmiani
Published: May 2024

Title: Directing the Image of Malang City as a Colonial City using the Serial Vision Method
Malang City has the potential for buildings representing it as a colonial city. Thomas Karsten was appointed as the planner and designer of Malang City. Urban planning and design results can be felt in the Bouwplan phase from 1917 to 1935. In contrast, Malang City already has elements of images of the city that form an urban image. The research aims to see whether the image of Malang City as a colonial city in the past is still visible today. The research seeks to rediscover traces of the colonial city through serial vision techniques with a synchronic view of the present. The method applied in the research is descriptive qualitative with synchronic data analysis. The data collection technique uses the serial vision method. The research was conducted in 2022 before the current traffic lane changes. From today's perspective, the traces of the colonial city are still quite strong, and the presence of the urban component is still visible through continuous vision. The results of serial vision observations show the elements that form the city's image. Even though the city image theory was put forward by Kevin Lynch in 1960, based on serial vision method tracking data obtained from observations in 2023, Thomas Kasten seems to have been able to think about this for a long time so that the results of his design formed the image of a colonial city.
Born again
Authors: Russo Jorge G. , Townsend Paul K.
Published: May 2024

Born’s original 1933 theory of nonlinear electrodynamics (in contrast to the later Born-Infeld theory) is acausal for strong fields. We explore the issue of strong-field causality violation in families of theories containing Born and/or Born-Infeld, and many variants that have been previously proposed in contexts that include cosmology and black hole physics. Many of these variants are acausal and hence unphysical. A notable exception is the modified Born-Infeld theory with ModMax as its conformal weak-field limit.
Multi-entropy at low Renyi index in 2d CFTs
Authors: Harper Jonathan , Takayanagi Tadashi , Tsuda Takashi
Published: May 2024

For a static time slice of AdS_33 we describe a particular class of minimal surfaces which form trivalent networks of geodesics. Through geometric arguments we provide evidence that these surfaces describe a measure of multipartite entanglement. By relating these surfaces to Ryu-Takayanagi surfaces it can be shown that this multipartite contribution is related to the angles of intersection of the bulk geodesics. A proposed boundary dual [Phys. Rev. D 106, 126001 (2022), J. High Energy Phys. 08, 202 (2023), J. High Energy Phys. 05, 008 (2023)], the multi-entropy, generalizes replica trick calculations involving twist operators by considering monodromies with finite group symmetry beyond the cyclic group used for the computation of entanglement entropy. We make progress by providing explicit calculations of Renyi multi-entropy in two dimensional CFTs and geometric descriptions of the replica surfaces for several cases with low genus. We also explore aspects of the free fermion and free scalar CFTs. For the free fermion CFT we examine subtleties in the definition of the twist operators used for the calculation of Renyi multi-entropy. In particular the standard bosonization procedure used for the calculation of the usual entanglement entropy fails and a different treatment is required.
Factors affecting the performance of independently practicing midwives
Authors: Yuniyati Eny , Eko Soetjipto Budi , Sudarmiatin  , Sopiah
Published: May 2024

The performance of midwives needs to be measured to provide guaranteed health services to mothers and children. Therefore, the aim of this study is to measure the performance of midwives using several variables, including internal branding, meaningfulness of work, work engagement, and innovative behavior, both directly and indirectly. The analysis was conducted in 29 districts and nine cities in East Java, Indonesia, with a sample of 330 midwives. Primary data were obtained by distributing questionnaires and analyzed using PLS-SEM. The research results show that all the variables tested have a positive and significant influence on midwifes’ performance. Innovative behavior has the strongest direct influence (73%), and meaningfulness of work has the weakest direct influence on midwifes’ performance (6%). Meanwhile, indirect relationships through work engagement provide a positive and significant influence, but are not as strong as the direct influence. These results offer practical insight for midwives to maintain and improve their individual performance, considering that more and more new midwives are ready to compete in providing health services for mothers and children.
Three-way interaction effect of entrepreneurial orientation, CEO power, and organizational slack on Indonesian firms’ performance
Authors: Ayu Kartika Maharani Ida , Alfina Alfina , Destari Fajar , Mujahidin Ali , Hiqmah Faizatul , Usman Indrianawati
Published: May 2024

This study aims to explore the complex interplay between entrepreneurial orientation, CEO power, and organizational slack, and their collective impact on firm performance within Indonesia’s manufacturing sector, providing actionable insights to optimize operations in a dynamic, resource-constrained environment. The paper employs a longitudinal approach, utilizing dynamic panel data from 127 publicly-traded manufacturing companies listed on the Indonesia Stock Exchange from 2014 to 2022, focusing on this sector due to its significant role in Indonesia’s economy and the unique challenges these firms face in adapting to market changes and competitive pressures. The study initially found that entrepreneurial orientation did not significantly influence firm performance. However, when CEO power was introduced into the analysis, it significantly, albeit negatively, moderated the effect of entrepreneurial orientation, suggesting that higher CEO power may actually diminish beneficial impacts of entrepreneurial orientation on performance (β = –48.041, p < 0.05). Importantly, the analysis revealed that organizational slack can positively interact with both entrepreneurial orientation and CEO power, mitigating this negative influence and enhancing firm performance (β = 15.261, p < 0.05). These findings illuminate the complex interdependencies within strategic management, underscoring the necessity of aligning upper echelon power dynamics with organizational resources. This alignment is crucial for leveraging the full potential of entrepreneurial orientation to enhance firm performance.
AcknowledgmentsThis study received sponsorship from Beasiswa Pendidikan Indonesia and Lembaga Pengelola Dana Pendidikan (Indonesia Endowment Fund for Education). The support from these organizations has been invaluable in the completion of this work, enabling comprehensive data collection and analysis crucial to complete the study.
Post-treatment of anaerobically digested sewage for nutrient removal
Authors: Haandel A. V. , Santos S. L. , Allegue T. , Garrido J. M.
Published: May 2024

Although modern anaerobic sewage treatment systems and in particular the upflow anaerobic sludge blanket reactor (UASB) have demonstrated remarkable performance in tropical and subtropical regions, the effluent quality is generally not compatible with discharge standards in many countries, so post-treatment becomes necessary. In practice, the most widely applied post-treatment options are polishing ponds (PPs) and other aerobic treatment bioreactors. PPs are treatment units treating anaerobically pre-treated wastewater, which distinguishes them from conventional waste treatment ponds, wherein normally raw wastewater is treated. Anaerobic pre-treatment has a very profound influence on the configuration and operation of PPs, as will be shown in this chapter. Other aerobic post-treatments can be realized with conventional activated sludge systems, or more complex technological solutions including membrane bioreactors (MBRs) or trickling filters. The anaerobic–aerobic treatment has important advantages compared to the purely aerobic treatment: the volume and sludge production is much smaller, there is a possibility that the anaerobic–aerobic system operates with energetic self-sufficiency and the concentration of excess sludge is much higher facilitating its processing. An important problem of anaerobic–aerobic treatment is the difficulty of producing a final effluent with low nutrient concentration. Anaerobic sewage treatment reduces the content of biodegradable organic matter in the effluent, limiting in practice the removal of phosphorus to the use of chemical precipitation systems. For the case of nitrogen, the alternatives only go through new processes, which complement the poor capacity of conventional denitrification due to the limited concentration of biodegradable organic matter. This limits in practice, the nitrogen elimination capacity of activated sludge systems or trickling filters treating effluents from UASB reactors. A notable breakthrough could occur if reliable partial nitrification anammox processes for the water line were developed, as these are still under development, or systems in which the dissolved methane present in the anaerobic effluents was used to denitrify, as it has already been observed in some MBRs.
Maximizing sustainability by energy recovery in anaerobic treatment systems
Authors: Haandel A. V. , Santos S. L. , Allegue T. , Garrido J. M.
Published: May 2024

Traditionally, wastewater treatment systems require considerable energy input, but this has changed since modern anaerobic treatment systems were developed in the second half of the last century. The production of biogas opens the possibility to produce electric power, which may make these systems independent of external energy and may even become net energy producers. A second source of energy production in wastewater treatment systems is sludge production. After drying the sludge its combustion can generate energy, though less than the energy potential from biogas, not only due to the reduced sludge mass, but also because solid fuel has a lower conversion efficiency than gaseous fuel. It has been demonstrated that in an efficient anaerobic treatment system operating under favourable conditions (warm climate, low-sulphate concentration in the influent) ∼1/6 of the influent organic material is converted into sludge whereas 4/6 is converted into biogas and 1/6 leaves the anaerobic treatment system with the treated effluent. Normally, the production of electric power from the biogas is more than sufficient to run the treatment system and an external source energy is not required. However, this does not mean that energy production is always a sound economic solution. Economic feasibility depends on the price of electric power and generally requires the operation of a large treatment system. In this chapter, equations are derived to estimate the composition of biogas and sludge in anaerobic wastewater treatment systems and specifically the influence of sulphate in the influent is discussed. Moreover, the processes for collection and treatment of biogas and sludge are presented. The potential for useful energy generation from anaerobic treatment systems is analysed and several examples are presented in order to highlight the feasibility of the energy recovery under different operating conditions.
Pengaruh pupuk kandang dan pupuk kalium pada pertumbuhan dan hasil jagunganis (zea mays saccharata sturt.) Varietas Talenta
Authors: Setyaji Kurniawan , Sumarni Titin , Baskara Medha
Published: May 2024

Penggunaan pupuk anorganik secara berlebihan meninggalkan residu di dalam tanah sehingga dapat menurunkan kualitas tanah. Kombinasi pupuk anorganik dan pupuk organik dapat mengurangi dampak negatif akibat penggunaan pupuk anorganik serta dapat memperbaiki kualitas tanah. Penelitian ini dilaksanakan pada bulan Desember 2022 hingga Februari 2023 di Agrotechnopark Jatikerto, Kabupaten Malang. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) yang terdiri dari 10 perlakuan dan 3 ulangan sehingga terdapat 30 satuan percobaan. Hasil penelitian menunjukkan bahwa perlakuan KCl 75% + 15 ton ha-1 pupuk kandang ayam meningkatkan panjang tanaman, luas daun, berat kering tanaman, diameter tongkol, total padatan terlarut, bobot segar tongkol dengan kelobot, bobot segar tongkol tanpa kelobot dan bobot tongkol per hektar. Perlakuan KCl 75% + 15 ton ha-1 pupuk kandang ayam menunjukkan hasil yang tidak berbeda nyata dengan perlakuan KCl 250 kg ha-1 sehingga penambahan pupuk kandang dapat mengurangi penggunakan pupuk KCl. Hasil analisis R/C ratio menunjukkan bahwa perlakuan KCl 75% + 15 ton ha-1 menunjukkan nilai R/C ratio 1,40 sehingga usahatani jagung manis menggunakan perlakuan tersebut menguntungkan.
Kata kunci: jagung manis, pupuk kandang ayam, pupuk kalium
Uji Efektifitas Air Kelapa Sebagai ZPT Alami Untuk Meningkatkan Pertumbuhan Bibit Tanaman (Amorphophallus Oncphyllus)
Authors: Andam Sari Deliana , Karmaita Yummama , Kurniasih Dedeh , Illahi Ayu Kurnia
Published: May 2024

Umbi porang yang saat ini diekspor masih berasal dari usaha masyarakat tani dengan mengumpulkan umbi yang tumbuh liar. TanamanporangdapatdiperbanyaksecaravegetatifdenganumbiKatak/Bulbil. Upayauntukmemperolehbenihdalamjumlahbanyakharusdilakukansecarageneratif,kendaladalamperbanyakanbenihporangsecara Generatifyaitubenihporangmengalamimasaistirahat/ Dormansi.  Mempercepatperkecambahanbenih porang yang berasal dari bulbil  dapat dilakukan  denganmerendambenihdalamlarutanzatpengaturtumbuhalami. Tujuan dari penelitian ini adalah sebagai berikut:1. Melihat pengaruh pemberian ZPT  Air Kelapa  terhadap perkecambahan tanaman porang. 2. Menentukan waktu perendaman ZPT  Air Kelapa  terhadap perkecambahan tanaman porang. Penelitian ini dilaksanakan pada bulan Mei sampai dengan September 2021 di Lahan Percobaan Politeknik Pertanian Negeri Payakumbuh. Bahan yang digunakan dalam penelitian ini adalah porang katak (Bulbil), Air Kelapa, sekam, tanah, pupuk kandang dan air. Sedangkan alat yang digunakan adalah ember, nampan, labu ukur, gelas piala, meteran, kamera, dan alat tulis. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL). Perlakuan yang digunakan adalah A= Perendaman air kelapa selama  1 jam, B = Perendaman air kelapa selama  2 jam, C = Perendaman air kelapa selama  3 jam, dan D = Perendaman air kelapa selama  3 jam. Hasil Penelitian diperoleh hasil waktu
Pengaruh Pemberian Air Kelapa terhadap Pertumbuhan dan Hasil Tanaman Selada Romaine (Lactuca Sativa L. Var. Longifolia) pada Sistem Hidroponik
Authors: Helmiawan Yusron , Aini Nurul
Published: May 2024

Selada romaine (Lactuca sativa L. var. longifolia) merupakan tanaman yang memiliki kandungan nutrisi dan nilai ekonomi yang tinggi. Teknik budibaya hiroponik merupakan teknik budidaya yang tepat untuk membudidayakannya karena memiliki waktu tanam yang singkat. Teknik budidaya hidroponik memerlukan tambah-an nutrisi agar dapat menunjang per-tumbuhan dan perkembangan tanaman agar lebih cepat yaitu dengan cara me-manfaatkan beberapa sumber hara dengan harga lebih murah seperti pemanfaatan air kelapa sebagai tambahan nutrisi. Air kelapa mengandung hormon yang dapat memacu pertumbuan tanaman. Penelitian ini bertujuan untuk memahami dan mem-pelajari pengaruh pemberian air kelapa sebagai nutrisi tambahan terhadap pertumbuhan dan hasil tanaman. Penelitian dilakukan pada greenhouse Agroteknopark, Jatikerto, Kec. Kromengan, Kab. Malang. Rancangan yang dilakukan menggunakan rancangan acak lengkap (RAL) dan menggunkan uji DMRT (Duncan Multiple range test) taraf 5%, dengan perlakuan yaitu: P0 (pelakuan kontrol), perlakuan air kelapa muda, M100 (100ml), M200 (200ml), M300 (300ml), perlakuan air kelapa tua, T100 (100ml), T200 (200ml), T300 (300ml). Berdasarkan hasil pengamatan perlakuan T100 (air kelapa tua 100ml) berpengaruh nyata terhadap pertumbuhan dan hasil tanaman selada. Hal tersebut dapat dilihat dari beberapa parameter seperti panjang tanaman, volume akar, dan berat segar tanaman yang menunjukkan nilai yang nyata lebih tinggi dari perlakuan kontrol (P0).
Pengaruh Pemberian Konsentrasi Eco-Enzyme dan Dosis Pupuk NPK Terhadap Pertumbuhan Rumput Bermuda (Cynodon dactylon (L.) Pers.) Var. Tifway
Authors: Safitri Syanel Zalza , Baskara Medha
Published: May 2024

Rumput bermuda (Cynodon dactylon (L.) Pers.) Var. Tifway. Merupakan salah satu jenis rumput lanskap yang paling sering digunakan sebagai sebagai penutup lahan. Hal ini menyebabkan permintaan rumput bermuda semakin meningkat. Untuk itu perlu mengoptimalkan kualitas maupun kuantitas rumput bermuda melalui pemupukan. Penggunaan pupuk anorganik NPK Mutiara lokal dan pupuk organik eco-enzyme dapat diterapkan dalam budidaya rumput bermuda. Tujuan dari penelitian yang akan dicapai dalam penelitian ini adalah untuk mendapatkan konsentrasi eco-enzyme dan dosis pupuk NPK yang sesuai untuk pertumbuhan tanaman rumput bermuda. Penelitian dilaksanakan di Kecamatan Kepanjen, Kabupaten Malang. Penelitian dilakukan menggunakan Rancangan Acak Kelompok Faktorial (RAKF). Faktor pertama adalah konsentrasi eco-enzyme yang terdiri dari taraf perlakuan 0 ml L-1 (E0), 20 ml L-1 (E1), dan 40 ml L-1 (E2). Faktor kedua yaitu dosis pemupukan NPK yang terdiri dari taraf perlakuan 0 kg ha-1 (N0), 320 kg ha-1 (N1), dan 630 kg ha-1 (N2). Pengamatan yang dilakukan meliputi jumlah anakan, panjang akar, bobot segar tanaman, bobot kering tanaman, dan persentase penutupan rumput. Data yang telah didapatkan kemudian dianalisis menggunakan Analisis Ragam dengan taraf koreksi 5%. Apabila pengaruh yang didapatkan nyata maka dilanjutkan Uji Beda Nyata Jujur (BNJ) pada taraf 5%. Hasil penelitian menunjukan bahwa rumput bermuda dengan konsentrasi eco-enzyme 40 ml L-1 (E2) dan pupuk NPK 630 kg ha-1 (N2) mampu menghasilkan jumlah anakan, bobot segar tanaman, bobot kering tanaman, dan persentase penutupan rumput. Pada perlakuan konsentrasi eco-enzyme 40 ml L-1 (E2) mampu menghasilkan panjang akar.
The Personality Inventory for DSM-5-Brief Form (PID-5-BF): Psychometric indicators in a Brazilian community sample
Authors: Barchi-Ferreira Ana Maria , L. Osório Flávia
Published: May 2024

Objective: To investigate psychometric properties (internal structure, convergent/discriminant validity, internal consistency, and test-retest) of the Personality Inventory for DSM-5-Brief Form (PID-5-BF) in a Brazilian community sample. Method: This is a study with a psychometric design. A sample of 527 adults from the general population (69.9% women; 33.5 ± 14.0 years; 74.0% ≥ 12 years education) responded to the instrument online after the study was disseminated on social networks and to the researchers’ contacts. The NEO-PI-R and sociodemographic questionnaire were applied besides the PID-5-BF, and a retest was applied 15-30 days after the initial assessment for reliability assessment. Data were analyzed using statistical techniques (IBM SPSS19 and Factor20); the significance level was set at p ≤ 0.05 for all the analyses. Results: Internal consistency was verified using Cronbach’s alpha and was adequate (domains α ≥ 0.69; total α = 0.87), in addition to test-retest reliability (domains ICC ≥ 0.82; total ICC = 0.95). Divergences were found between the PID-5-BF different domains despite them being significantly correlated with each other. Convergent validity with the NEO-PI-R was adequate, with moderate/strong correlations between the domains theoretically associated (r > 0.38). The internal structure (Exploratory Factor Analysis) indicated that the original five-factor model (CFI = 0.991; TLI = 0.986; RMSEA = 0.033) and one-factor model were adequate (CFI = 0.908; TLI = 0.899; RMSEA = 0.089. Conclusions: The findings support using the PID-5-BF Brazilian version, which presented adequate psychometric properties comparable to the original version. This instrument can be helpful in the clinical and research fields to screen general and specific traits of personality pathology. Future studies are suggested to expand the psychometric findings among clinical samples, confirming the instrument’s scope of reach.
Electrical Energy Audit in Pratama Tapan Hospital
Authors: Putra Nanda Okta , Aini Zulfatri , Putri Dila Marta
Published: May 2024

Hospitals, as large energy consumers, must adopt efficient energy-saving measures due to cost increases, regulations, and climate change concerns. In this study, an electrical energy audit was conducted at Pratama Tapan Hospital to identify energy-saving opportunities and recommend equipment replacements or technology upgrades. The primary objective was to determine the Energy Consumption Intensity (ECI) and analyze the potential for energy savings. The audit re-vealed an ECI value of 10.33 kWh/m²/year, highly efficient by ASEAN-USAID standards. However, 100% of rooms didn't meet the SNI 03-6197-2000 light intensity standard, causing discomfort. The study recommends installing specific light fixtures and adjusting lamp power to comply with the standard. These findings offer valuable insights for healthcare institutions striv-ing to achieve sustainability goals.
Development of Teaching Factory Learning Model in Industrial Automation in Vocational High Schools
Authors: Hatmojo Yuwono Indro , Ikhsannudin Wahyu
Published: May 2024

Vocational High Schools, as schools that aim to prepare students for work in a particular field, need effectiveness in the learning process. Its effectiveness must follow the real conditions required by the industry. With the rapid devel-opment of industry, industry-based learning, often called "Teaching Factory," is one of the right role models of learning. The type of research to be carried out is development research. The purpose of this study is to determine (1) the devel-opment of the teaching factory learning model, (2) the application of the teach-ing factory learning model, (3) user response to the product, and (4) the effec-tiveness of using the developed product. The development model used in this study is the Plomp development model. The Plomp development model includes (1) the initial investigation phase, (2) the design phase, (3) the realiza-tion/construction phase, (4) the testing, evaluation, and revision phase, and (5) the field test/implementation phase. Validity by model experts about the teach-ing factory learning model gets an average score of 95.45 and is included in the very decent category. The material expert gave it a score of 93.41, and it be-longs to the very decent category. The media expert gave it a score of 95.84, which belongs to the decent category. The effectiveness test result shows a sig-nificant difference between the learning outcomes in the Industrial Automation Engineering Expertise Concentration subjects before and after applying the Teaching Factory learning model. This shows the positive influence and effectiveness of using the Teaching Factory learning model on the learning out-comes of the Industrial Automation Engineering Expertise Concentration in In-dustrial Automation Engineering Vocational School students.
Influence of Field Work Practices, Work Motivation, and Communication Skills on Vocational School Students' Work Readiness
Authors: Deanda Galeri Garnisha , Darmawan Ilham Akbar , Irwanto Irwanto
Published: May 2024

Based on the latest data from the Serang Regency Central Statistics Agency in 2022, the Open Unemployment Rate (TPT) of Vocational High School (SMK) graduates is still relatively high compared to graduates of other levels of education, namely 12.87%. Apart from that, from the results of observations, there are still many vocational school students who still need to be ready for work. This is because the industrial internship program has not been able to optimize students' work readiness, students' work motivation still needs to be visible, and students' communication skills still need to be improved for their readiness to enter the world of work. This research seeks to determine the influence of industrial internship, work motivation, and communication skills on vocational school students' work readiness. This research uses a quantitative approach to answer the research hypothesis, which asks whether industrial internship, work motivation, and communication skills are positively correlated with vocational school students' work readiness. This research used a questionnaire distributed to 180 students in seven vocational schools in Serang Regency. This research proved that industrial internship, work motivation, and communication skills significantly influence work readiness (7%). For the conclusions and limitations of existing research, this research provides several suggestions for improving vocational school students' work readiness by paying more attention to the variables of industrial internship, work motivation, and communication skills.
An empirical study on the behavioral intentions of medical centers and regional hospitals in holistic medicine education (Preprint)
Authors: Kung Liang-Hsi , Kung Chih-Ming , Hsing Shu-Chen , Yan Yu-Hua
Published: May 2024

BACKGROUND

Holistic medicine education is gaining importance in medical training and practice, yet implementation varies across medical centers and regional hospitals. This study examines the attitudes and perceptions of clinical supervisors and postgraduate trainees toward holistic medicine education in Taiwan.

OBJECTIVE

To compare attitudes and perceptions between clinical supervisors and postgraduate trainees in medical centers and regional hospitals, and to identify factors influencing holistic medicine education implementation.

METHODS

A cross-sectional survey from July to December 2022 sampled clinical supervisors and postgraduate trainees from two medical centers and two regional hospitals in Taiwan. A structured anonymous questionnaire, grounded in the theory of planned behavior, gathered data. Descriptive statistics and independent t-tests analyzed responses from 703 participants.

RESULTS

Clinical supervisors showed more positive attitudes toward holistic medicine education than postgraduate trainees. Medical centers exhibited higher perceived behavioral control and medical education behavioral intention compared to regional hospitals. Influencing factors identified included institutional norms, perceived behavioral control, and subjective norms, all pivotal for enhancing holistic medicine education implementation.

CONCLUSIONS

Hospitals should consider identified influencing factors and establish institutional norms to bolster holistic medicine education. These insights aid in crafting effective strategies for promoting holistic medicine education in medical training and clinical practice.

CLINICALTRIAL

No
Oppression framework informed equity cost-effectiveness analysis of diabetic retinopathy screening – protocol paper (Preprint)
Authors: Stanimirovic Aleksandra , Francis Troy , Meerai Sonia , Mathew Suja , Ibrahim Sarah , PIkula Aleksandra , Rac Valeria E.
Published: May 2024

BACKGROUND

Diabetic retinopathy remains primary vision complication of diabetes and leading cause of blindness among adults, with up to 30% prevalence among low-income population. Tele-retina is cost-effective screening alternative to vision loss prevention, yet there is adverse association between screening and income. Intersectionality theory notes barriers to achieving health equity result from intersection of personal social characteristics (i.e., race and income). Experiences at intersections are influenced by interpersonal and structural systems of oppression (i.e., racism). Studies found Tele-retina is dominant strategy to standard of care screening for at risk populations. No study has assessed economic equity impact of DR screening using theoretical foundation. Economic evaluations should consider social inferences of technologies on patient health and health care system.

OBJECTIVE

To address shortcomings related to the utilization of intersectionality theory in economic evaluations of DR screening, we propose oppression framework informed equity CEA of DR screening program.

METHODS

A deductive theoretical drive sequential multimethod approach, consisting of 1) modified delphi  2) CASE STUDY OF OPPRESSION FRAMEWORK INFORMED EQUITY CEA. Through Delphi (Panel (N=35-50) - Patient Partners, Field experts, Decision makers) we will select the social constructs to, alongside intersectionality theory, guide modification of equity informed CEA to understand impact of social constructs on economic outcomes. Social constructs will be integrated into validated Tele-retina CEA model.

RESULTS

The Delphi study will provide an understanding on which social factors are deemed important by the stakeholders for guiding the inequity in care access. We may input some/all social factors into the DCEA model or create distinctive context dependent scenarios.

CONCLUSIONS

This is first Canadian study to: 1) mainstream how health equity framework and social constructs are utilized in economic assessment, 2) improve Tele-retina screening programs by using health equity lens, and 3) scale and adopt “de-novo” integration of social constructs in economic models for evaluation of other programs.

CLINICALTRIAL

Not applcable.
Improvement of Awareness of Diabetes Mellitus Disease Risks and Self-Monitoring Motivation Through Blood Sugar Screening and Counseling for Dian Darat Village Community, Southeast Maluku
Authors: Meturan Dessy Marselina , Ethica Stalis Norma , Sukeksi Andri
Published: May 2024

Diabetes Mellitus (DM) disease is among the top 10 causes of death in the world. It is a metabolic disease causing unusual high blood sugar level in the body. Fortunately, controlling risk factors through early detection can prevent the abnormality. Dian Darat is among villages in Southeast Maluku Regency, where DM screening is rarely carried due to its relatively remote location. This community activity aimed to provide DM disease education through blood sugar screening and counselling for village’s community. Methods included early detection of DM and counselling based on blood sugar level screening results supported by poster media. Screening test results showed that 9 out of 26 respondents (35%) had blood sugar level higher than normal. Based on results of pre- and post-test scores before and after the education, there was an increase in participants’ knowledge regarding DM disease by 62 %. (from average score of 56,15 ± 13,88 to 90,77 ± 9,77, n=26, p ≤ 0.01). Future community services are recommended on similar and more sustainable community service activities by cooperation with other relevant stakeholders to optimize results.
Rehabilitation of Toothless Conditions with Dental Implants to Improve the Nutritional Status and General Health of the Terban Village Community
Authors: Rosanto Yosaphat Bayu , Listyarifah Dyah , Budi Nagari Hanni Handayani
Published: May 2024

Terban Village is a village that has a significant number of residents who suffer from toothless conditions. This condition directly affects the village population’s nutritional status and general health. This community service aimed to rehabilitate the condition of toothlessness with dental implants to improve the nutritional status and general health of the people of Terban Village. The methods used in this community service were counseling, general health, mental and dental examinations, health utility levels, radiological examinations, and dental implant treatment for the residents. The output of this community service was a counseling session that involved 70 Terban Village residents. The DMFT index of Terban Village residents was 7.47 and was still above the WHO baseline. Five respondents were selected to undergo rehabilitation procedures with dental implants. Rehabilitation of edentulous conditions with dental implants will have a positive impact on improving the nutritional status and general health of the people of Terban Village. In addition, the general health of the population has also experienced improvements, such as reducing the number of cases of nutrition-related diseases and improving the overall quality of life.
BIODEGRADATION OF GLYPHOSATE CONTAINING HERBICIDE BY SOIL FUNGI
Authors: Omorinola Alake A , Ogunbiyi Oluwagbenga J , Jegede Rotimi J , Adeleke Maryam A , Fakolade Benjamin A
Published: May 2024

Ten fungal isolates were isolated from two herbicide-contaminated soil farms obtained from Amoyo and the University of Ilorin environment in Kwara State after enrichment with mineral salt medium (MSM) supplemented with glyphosate-containing herbicide. The growth of fungal isolates was efficiently stimulated by the organophosphorus herbicide. Fungi isolated were subjected to screening by varying the herbicide concentrations from 0.1 to 3%, which is prepared with MSM. This screening showed that all the fungal isolates had the ability to act in the biodegradation process. However, varying degradative potentials were observed, as some had heavy growth while others had only slight or no growth as the concentrations of the herbicide increased. The ten fungal isolates were characterized and identified as Aspergillus niger, Penicillum spinulosum, Aspergillus terrus, Aspergillus flavus, Fusarium oxysporum, Mucor spp., Aspergillus oryzae, Aspergillus tamari, Rhizopus stolonifer, and Trichoderma koningii, and these were reduced to six after screening with 3% concentration of the herbicide. Four isolates (A. niger, F. oxysporum, Mucor spp., and A. flavus) were selected based on their growth ability on the medium during screening and were used in the biodegradation study. However, there is an increase in fungal dry weights ranging from 8.60 to 18% for 12 days. This shows that these fungi can be employed in the biodegradation of herbicides since they are potentially effective species and are environmentally safer alternative to protect the soil from the contamination of glyphosate-containing herbicide residues.
AN EXAMINATION OF TECHNIQUE OF CULTURAL FISH FARMING IN LAKE CHAD BASIN AREA OF NIGERIA
Authors: Zanna Babagana
Published: May 2024

The study was conducted in Lake Chad Basin area of Nigeria where Fishing has been the occupation of the inhabitants in the study area. The study focused on the cultural technique of fish farming in the study area. Data for the study was obtained from both primary and secondary sources through a public participation and stakeholders’ interview with the application of focus group discussion. The data collection for the research work was carried out within the period of 1st to 31st March 2023. Primarily, conservative qualitative method with snow-ball technique was applied and information was elicited from the respondents on technique of fish farming culture. The study revealed that technique of fish farming culture involves the use culturally believed norms of unsustainable age long intrinsic practice. Recommendation were made for the formulation of policy framework in connection to the cultural technique of fish farming and other related issues for the transformation and sustainability of the culture of fish farming in the study area.
IDENTIFICATION AND PHARMACOLOGICAL PROFILING OF PLANT PEPTIDES AS INHIBITORS OF CLOSTRIDIUM BOTULINUM NEUROTOXINS A AND B
Authors: BJ LOHITH
Published: May 2024

Objective: Clostridium botulinum causes botulism which is a neuroparalytic disease caused by neurotoxins that are caused all over the world. This disease is perceived as a food born disease caused by a potent neurotoxin. Plant peptides are those referred to as proteins at a length of small than 100 amino acids. Plants have antimicrobial properties present in almost all plant species. These plant peptides are classified based on their primary structures.
Methods: Molecular docking was implemented to evaluate the efficacy of nine phytocompounds from C. botulinum against the target proteins (3nf3, 2npo). PyRx, a Virtual Screening software was utilized for molecular docking which allowed the inspection of three-dimensional protein structures and the identification of potential binding sites.
Result: On analyzing the molecular docking result of puroindoline, impatiens exhibited the best binding affinity toward the two target proteins.
Conclusion: The safe and efficient treatment for some facial pleats and lines is botulinum toxin. High levels of patient and physician satisfaction are linked to its use. This paper has extensively revised three aspects the binding activity, models, and their phytochemical properties. The most significant results involve solvent interactions, van der Waals interactions, electrostatic interactions, and hydrogen bonding were analyzed and concluded in this research paper.
IN SILICO AND MOLECULAR DOCKING STUDIES: AIMING AMYLOID PRECURSOR-LIKE PROTEIN 2 USING ACTIVE PHYTOCHEMICALS FROM WITHANIA SOMNIFERA
Authors: KULSHRESTHA MIMANSA , WANARASE SHUBHAM
Published: May 2024

Objectives: Due to effective healing properties found in natural chemical compounds obtained from medicinal plants that are employed in curing several diseases, this study aims to exhibit the role of Indian ayurvedic plant Withania somnifera in the management of the Alzheimer’s disease (AD) utilizing the molecular docking, drug-likeness and absorption, distribution, metabolism, and excretion (ADME) analysis.
Methods: Alzheimer’s main protein was collected from the PDB database. Molecular docking is achieved using PyRx tool with the removal of the ligands possessing improper binding showing a significant effect on docking. Drug likeness and ADME analysis were evaluated using Swiss-ADME web server and ADMETlab 2.0 web tool. Ramachandran plot analysis for the target protein was achieved using SWISS-MODEL web server.
Results: In the protein structure, the distribution of torsion angles ϕ and ψ in a protein is visible. On the basis binding affinity ADME analysis, 27-Deoxywithaferin A is a safe medication and one of the most effective inhibitors of the amyloid precursor protein. It also has drug-like qualities.
Conclusion: According to the current research, 27-Deoxywithaferin A has a high affinity for binding, which makes it possible to suppress the major amyloid precursor protein while also managing therapeutic approaches for treating AD.
PERSPECTIVES OF CLINICAL EXPERTS ON THE CURRENT USAGE PATTERNS AND THE PREFERENCE OF VILDAGLIPTIN IN THE TREATMENT OF TYPE 2 DIABETES
Authors: S Manjula , KUMAR M KRISHNA
Published: May 2024

Objective: Although the efficacy and safety of vildagliptin have been proven in randomized clinical trials, data regarding the improved and up-to-date understanding on the management of Type 2 diabetes mellitus from the context of Indian diabetic patients, are scarce. This study was conducted to assess the opinions of clinical experts on the current usage patterns of vildagliptin in the management of Type 2 diabetes among Indian patients.
Methods: A cross-sectional, questionnaire-based study was conducted to collect opinion among physicians in endocrinology across India between June 2022 and December 2022. Convenient sampling method was used. Descriptive statistics were used to summarize the characteristics of the study by employing frequencies and percentages.
Results: It was observed that 95 out of 188 clinicians preferred dipeptidyl peptidase-4 (DPP4) inhibitors (DPP4i) and only 35 out of 188 clinicians (18.6%) opted a combination of Metformin and DPP4 inhibitors as the first hypoglycemic agent for newly detected diabetes. In addition, 141 out of 188 (75%) prescribed vildagliptin only as their preferred drug in the class of DPP4 inhibitors. Further, the reason behind such a high-yielding response for vildagliptin among clinicians and their patients, was its weight-neutral property primarily and posing a low risk of adverse effects. Nearly, half of the clinicians reported a 0.6–1% drop in glycosylated hemoglobin (HbA1c) levels in patients within 3 months of vildagliptin use.
Conclusion: This study concluded that the majority of the specialists preferred using vildagliptin among other DPP4 inhibitors and pointed out that vildagliptin lowered HbA1c within 3 months of use.