bluuebunny/crossref_metadata_2025 huggingface dataset:
Ischemia reperfusion injury provokes adverse left ventricular remodeling in dysferlin-deficient hearts through a pathway that involves TIRAP dependent signaling
Authors: Evans Sarah , Weinheimer Carla J. , Kovacs Attila , Williams Jesse W. , Randolph Gwendalyn J. , Jiang Wenlong , Barger Philip M. , Mann Douglas L.
Published: August 2020

Cardiac myocytes have multiple cell autonomous mechanisms that facilitate stabilization and repair of damaged sarcolemmal membranes following myocardial injury. Dysferlin is a protein which facilitates membrane repair by promoting membrane resealing. Although prior studies have shown that dysferlin-deficient (Dysf−/−) mouse hearts have an impaired recovery from acute ischemia/reperfusion (I/R) injury ex vivo, the role of dysferlin in mediating the recovery from myocardial injury in vivo is unknown. Here we show that Dysf−/− mice develop adverse LV remodeling following I/R injury secondary to the collateral damage from sustained myocardial inflammation within the infarct zone. Backcrossing Dysf−/− mice with mice lacking signaling through the Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein (Tirap−/−), attenuated inflammation and abrogated adverse LV remodeling following I/R injury. Subsequent studies using Poloxamer 188 (P188), a membrane resealing reagent, demonstrated that P188 did not attenuate inflammation nor prevent adverse LV remodeling in Dysf−/− mice following I/R injury. Viewed together these studies reveal a previously unappreciated role for the importance of membrane sealing and the resolution of inflammation following myocardial injury.
Publisher Correction: Classification of aggressive and classic mantle cell lymphomas using synchrotron Fourier Transform Infrared microspectroscopy
Authors: Kolodziej Magdalena , Jesionek-Kupnicka Dorota , Braun Marcin , Atamaniuk Vitaliy , Sloniec Sylwia , Cebulski Jozef , Cholewa Marian , Kopczynski Janusz , Heraud Philip , Tobin Mark J. , Vongsvivut Jitraporn , Zawlik Izabela
Published: August 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Comparative analysis of racial differences in breast tumor microbiome
Authors: Thyagarajan Srikantha , Zhang Yan , Thapa Santosh , Allen Michael S. , Phillips Nicole , Chaudhary Pankaj , Kashyap Meghana V. , Vishwanatha Jamboor K.
Published: August 2020

Studies have demonstrated that environmental, host genetic, and socioeconomic factors influence the breast cancer prevalence landscape with a far-reaching influence on racial disparity to subtypes of breast cancer. To understand whether breast tissue harbors race-specific microbiota, we performed 16S rRNA gene-based sequencing of retrospective tumor and matched normal tissue adjacent to tumor (NAT) samples collected from Black non-Hispanic (BNH) and White non-Hispanic (WNH) women. Analysis of Triple Negative Breast cancer (TNBC) and Triple Positive Breast Cancer (TPBC) tissues for microbiota composition revealed significant differences in relative abundance of specific taxa at both phylum and genus levels between WNH and BNH women cohorts. Our main findings are that microbial diversity as measured by Shannon index was significantly lower in BNH TNBC tumor tissue as compared to matched NAT zone. In contrast, the WNH cohort had an inverse pattern for the Shannon index, when TNBC tumor tissue was compared to the matched NAT. Unweighted Principle Coordinates Analysis (PCoA) revealed a distinct clustering of tumor and NAT microbiota in both BNH and WNH cohorts.
Improvement of sleep quality after treatment in patients with lumbar spinal stenosis: a prospective comparative study between conservative versus surgical treatment
Authors: Kim Jihye , Lee Seung Hun , Kim Tae-Hwan
Published: August 2020

Despite the importance of sleep and the evidence on its relationship with various chronic diseases, quality of sleep is not considered in patients with lumbar spinal stenosis (LSS). This prospective comparative study aimed to investigate the changes in sleep disturbance after treatment in patients with LSS. Patients with LSS and sleep disturbance (n = 201; 147 conservatively treated and 54 patients with surgical treatment) were included. The Pittsburgh sleep quality index (PSQI) was used to evaluate sleep quality. Propensity score matching was used to attenuate the potential bias. Clinical outcome of surgery, as determined by the Oswestry disability index, and the PSQI was compared between the two groups at 6 weeks, 3 months, and 6 months after enrollment. Multivariate logistic analysis was performed to adjust for possible confounders within the matched cohorts. Among the 201 patients, 96 (47.7%) patients were finally matched (48 patients in each group). Sleep quality was initially improved after treatment, regardless of the treatment method. Sleep quality in the surgical group was improved by 6 weeks after surgery and consistently improved during the 6-month follow-up period, despite less use of pain killer. Conversely, the improvement in sleep quality at 6-weeks following conservative treatment was not maintained during the follow-up, although the treatment outcome for LSS measured by ODI was continuously improved. After multivariate logistic regression analysis within propensity score matched cohorts, surgical treatment had a significantly greater chance to improve sleep quality compared to conservative treatment. The failure of sleep improvement in conservative group was significantly associated with depression presented by worse score in Hamilton depression rating scale, and more severe degree of foraminal-type stenosis, which should be carefully considered for conservative treatment of LSS patients with sleep disturbance.
Development and validation of a nomogram to predict the prognosis of patients with gastric cardia cancer
Authors: Shi Xiuquan , Xu Lijun , Ma Bingwei , Wang Siben
Published: August 2020

Our goal was to develop a prognostic nomogram to predict overall survival (OS) and cancer-specific survival (CSS) in patients with gastric cardia cancer (GCC). Patients diagnosed with GCC from 2004 to 2015 were screened from the surveillance, epidemiology, and end results (SEER) database. A nomogram was developed based on the variables associated with OS and CSS using multivariate Cox analysis regression models, which predicted 3- and 5-year OS and CSS. The predictive performance of the nomogram was evaluated using the consistency index (C-index), calibration curve and decision curve analysis (DCA), and the nomogram was calibrated for 3- and 5-year OS and CSS. A total of 7,332 GCC patients were identified and randomized into a training cohort (5,231, 70%) and a validation cohort (2,200, 30%). Multivariate Cox regression analysis showed that marital status, race, SEER stage, grade, T stage, N stage, M stage, tumor size, and surgery were independent risk factors for OS and CSS in GCC patients. Based on the multivariate Cox regression results, we constructed prognostic nomograms of OS and CSS. In the training cohort, the C-index for the OS nomogram was 0.714 (95% CI = 0.705–0.723), and the C-index for the CSS nomogram was 0.759 (95% CI = 0.746–0.772). In the validation cohort, the C-index for the OS nomogram was 0.734 (95% CI = 0.721–0.747), while the C-index for the CSS nomogram was 0.780 (95% CI = 0.759–0.801). Our nomogram has better prediction than the nomogram based on TNM stage. In addition, in the training and external validation cohorts, the calibration curves of the nomogram showed good consistency between the predicted and actual 3- and 5-year OS and CSS rates. The nomogram can effectively predict OS and CSS in GCC patients, which may help clinicians personalize prognostic assessments and clinical decisions.
Lessons Learned from Recent Clinical Trials Targeting Diets to Treat and Prevent Obesity and Diabetes
Authors: Wright N. S.
Published: August 2020

Obesity and Type 2 diabetes (T2D) are globally significant health conditions that are projected to worsen. Obesity results from chronic positive energy balance, and T2D is strongly related to obesity. Results from meta-analyses comparing low- and high-fat dietary approaches show no clear differences in long-term outcomes for weight loss or diabetes, although there is better-quality long-term evidence for low-fat approaches. Across the range of dietary strategies presented weight loss ranges from 0 to 11 kg at 1 year. Discussed are relevant mechanistic signaling pathways for obesity and T2D for both low- and high-fat approaches. A convergence of evidence agrees nutrient-rich, low-energy density plant-based foods promote health for people diagnosed with obesity and/or T2D. All diets appear to have difficulties with long-term adherence. More high-quality research is needed.
Nutritional Regulation of Inflammation in Obesity and Diabetes
Authors: Wang Xin , Liu Jian
Published: August 2020

For decades, the prevalence of obesity and Type 2 diabetes has been rising, becoming significant threats to human health worldwide. Accumulating evidence indicates that excess energy nutrition causes chronic low-grade tissue inflammation and finally contributes to systemic metabolic dysfunction, while various natural products such as polyphenols, alkaloids, terpenoids, and n3-polyunsaturated fatty acids exert anti-inflammatory benefits. As an energy reservoir, adipose tissue depots play a vital role in energy storage and inflammatory regulation. In this chapter, we will focus on adipose tissues and talk about the molecular and cellular mechanisms that link nutrition to obesity and diabetes, since we outline the natural products as strategies to combat these metabolic syndromes.
Metabolomics in Nutritional Metabolism, Obesity, and Diabetes
Authors: Bervoets L. , Adriaensens P.
Published: August 2020

This chapter reviews a series of metabolomic studies carried out in previous years on the utility and application of nuclear magnetic resonance (NMR)-based metabolomics in an attempt to understand pathophysiological mechanisms in obesity and diabetes. The first part focuses on several methodological concerns that are critical to blood plasma 1H NMR experimental design in clinical, biobank and multicentre research settings. Variations in sample collection, preparation and storage within the field of clinical metabolomics might hamper the effective implementation of 1H NMR spectroscopy. We describe and comment on specific precautions or improvements that should be taken into account at each experimental stage when performing 1H NMR-based metabolomics research on plasma samples. Next, we discuss the application of 1H NMR-metabolite phenotyping in the context of childhood obesity and diabetes. NMR-based metabolomics offers a complementary tool to traditional screening in order to more accurately and comprehensively identify metabolic risk profiles. In the end, more targeted and effective screening and intervention strategies for obesity and early-onset diabetes can be developed.
Immunostimulatory biomaterials to boost tumor immunogenicity
Authors: Shofolawe-Bakare Oluwaseyi T. , Stokes Larry D. , Hossain Mehjabeen , Smith Adam E. , Werfel Thomas A.
Published: August 2020

This review highlights recent progress to develop biomaterials that boost tumor immunogenicity and improve the response rate to cancer immunotherapies.
Reversible spatial and temporal control of lipid signaling
Authors: Gaur Pankaj , Galkin Maksym , Hauke Sebastian , Redkin Ruslan , Barnes Carolyn , Shvadchak Volodymyr V. , Yushchenko Dmytro A.
Published: August 2020

Fluorescent cages for selective delivery of photoswitchable lipids to specific cell membranes for high-precision studies of lipid signaling.
Iron-catalysed 1,2-aryl migration of tertiary azides
Authors: Wei Kaijie , Yang Tonghao , Chen Qing , Liang Siyu , Yu Wei
Published: August 2020

1,2-Carbon to nitrogen aryl migration of α,α-diaryl tertiary azides was realized by using FeCl2 and N-heterocyclic carbene SIPr·HCl as a catalyst.
Light-enabled, AlCl3-catalyzed regioselective intramolecular nucleophilic addition of non-nucleophilic alkyls to alkynes
Authors: Zhang Yanbin , Jin Ruiwen , Pan Guangxing , Guo Hao
Published: August 2020

Light-enabled, AlCl3-catalyzed regioselective intramolecular nucleophilic cyclization of alkynes using non-nucleophilic alkyls as the nucleophile is reported.
Histidine-triggered turning-on of gold/copper nanocluster fluorescence for the sensitive and selective detection of histidine
Authors: Cai Yuanyuan , Wang Jin , Liu Chongyang , Yang Shuqing , Zhang Yujiao , Liu Aihua
Published: August 2020

Gold/copper nanoclusters with histidine-triggered turn-on fluorescence for sensing histidine sensitively and selectively.
Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors
Authors: Hosoya Yusuke , Nojo Wataru , Kii Isao , Suzuki Takanori , Imanishi Miki , Ohkanda Junko
Published: August 2020

Fluorescent-based library screening for the DNA-binding of disordered BMAL1 and CLOCK identified heterocyclic inhibitors which possess low micromolar activity.
A large kinetic isotope effect in the reaction of ascorbic acid with 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO˙) in aqueous buffer solutions
Authors: Nakanishi Ikuo , Shoji Yoshimi , Ohkubo Kei , Ozawa Toshihiko , Matsumoto Ken-ichiro , Fukuzumi Shunichi
Published: August 2020

A large kinetic isotope effect (kH/kD) was observed for the reaction of ascorbic acid (AscH2) with 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO˙).
Constructing a ternary H2SrTa2O7/g-C3N4/Ag3PO4 heterojunction based on cascade electron transfer with enhanced visible light photocatalytic activity
Authors: Ren Yi , Zhan Wenqi , Tang Lulu , Zheng Hui , Liu Huimin , Tang Kaibin
Published: August 2020

A ternary H2SrTa2O7/g-C3N4/Ag3PO4 heterojunction was fabricated for the first time and displayed excellent visible light photocatalytic activity.
Facile preparation of nanoparticle based SERS substrates for trace molecule detection
Authors: Demirtaş Özge , Doğanay Doğa , Öztürk İbrahim Murat , Ünalan Hüsnü Emrah , Bek Alpan
Published: August 2020

Strong plasmonic activity with EFs up to 108 at as low as 1% surface coverage is possible due to the distinct properties of polyol synthesized AgNPs such as atomically flat surfaces, sharp edges and corners.
Excited-state photophysical processes in a molecular system containing perylene bisimide and zinc porphyrin chromophores
Authors: Yang Fan , Wu Yanzhou , Zhao Juan , Guo Yiting , Guo Xudong , Li Weiwei , Wang Jianping
Published: August 2020

The photophysical behavior of PDI–ZnPor–PDI in both film- and solution-forms has been investigated using steady-state and transient absorption spectroscopy measurements.
Interplay between two radical species in the formation of periodic patterns during a polymerization reaction
Authors: Sato Daisuke , Itatani Masaki , Matsui Jun , Unoura Kei , Nabika Hideki
Published: August 2020

Interplay between initiator and monomer radicals forms periodic precipitation of polymers.
Borophosphene as a promising Dirac anode with large capacity and high-rate capability for sodium-ion batteries
Authors: Zhang Yang , Zhang Er-Hu , Xia Ming-Gang , Zhang Sheng-Li
Published: August 2020

Borophosphene can be used as a promising Dirac anode material for SIBs with excellent performance including a large specific capacity, a low diffusion energy barrier and favorable cyclability.
Temperature dependent molecular fluorescence of [Agm]n+ quantum clusters stabilized by phosphate glass networks
Authors: Ren Kai , Xu Xiuxia , Yao Zeyu , Chen Xiaotong , Hu Tian , Li Pengcheng , Fan Xianping , Du Jincheng , Qiao Xvsheng , Qian Guodong
Published: August 2020

Phosphate glass stabilized silver quantum clusters, [Agm]n+, exhibit temperature dependent molecular fluorescence with high quantum efficiencies.
The role of surface properties in CO2 methanation over carbon-supported Ni catalysts and their promotion by Fe
Authors: Gonçalves Liliana P. L. , Sousa Juliana P. S. , Soares O. Salomé G. P. , Bondarchuk Oleksandr , Lebedev Oleg I. , Kolen'ko Yury V. , Pereira M. Fernando R.
Published: August 2020

CO2 methanation over activated carbon-supported Ni catalysts with enhanced surface chemistry properties and their improved performance by Fe promotion.
Similarities and differences between Mn(ii) and Zn(ii) coordination polymers supported by porphyrin-based ligands: synthesis, structures and nonlinear optical properties
Authors: Xu Bo-Wei , Niu Ru-Jie , Liu Quan , Yang Jun-Yi , Zhang Wen-Hua , Young David J.
Published: August 2020

Pyridine- and pyridinemethanol-based coordination polymers of Mn(ii) and Zn(ii) with porphyrinic ligand skeleton demonstrate rich similarities and differences in terms of solution and solid-state properties.
New quaternary chalcogenide Ba4HgAs2S10originating from the combination of linear [HgS2]2−and tetrahedral [AsS4]3−modules
Authors: Xing Wenhao , Wang Naizheng , Li Zhuang , Liu Wenhao , Tang Jian , Yin Wenlong , Lin Zheshuai , Kang Bin , Yao Jiyong
Published: August 2020

A new quaternary chalcogenide Ba4HgAs2S10is constructed by combining linear HgS22−and tetrahedral AsS43−modules.
Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2
Authors: Song Shuang , Peng Haoran , Wang Qingling , Liu Zhengqi , Dong Xiuping , Wen Chengrong , Ai Chunqing , Zhang Yujiao , Wang Zhongfu , Zhu Beiwei
Published: August 2020

Sulfated polysaccharide from sea cucumber (SCSP), fucoidan from brown algae, and iota-carrageenan from red algae show inhibitory activities against SARS-CoV-2.
Open-shell donor–π–acceptor conjugated metal-free dyes for dye-sensitized solar cells
Authors: Sabuj Md Abdus , Rai Neeraj
Published: August 2020

Open-shell dyes with small diradical character (y < 0.10) lead to absorption in the near-infrared region.
Bottom-up synthesis of nitrogen-doped nanocarbons by a combination of metal catalysis and a solution plasma process
Authors: Zhou Yang , Nishina Yuta
Published: August 2020

We developed a bottom-up synthesis of nanocarbons with specific functions from molecules without leaving groups, by employing a metal catalyst under solution plasma irradiation. Using pyridine, the nitrogen-doped nanocarbon was synthesized by this method.
Simultaneous extraction of permethrin diastereomers and deltamethrin in environmental water samples based on aperture regulated magnetic mesoporous silica
Authors: Zhang Meixing , Mei Jie , Lv Siying , Lai Jiahao , Zheng Xiaoni , Yang Jing , Cui Shihai
Published: August 2020

The aperture of KIT-6 can influence the recoveries of magnetic solid phase extraction.
Hydrogen bonding interactions in fluorinated 1,2,3-triazole derivatives
Authors: Espitia Cogollo E. , Piro O. E. , Echeverría G. A. , Tuttolomondo M. E. , Pérez H. , Jios J. L. , Ulic S. E.
Published: August 2020

Comprehensive theoretical, structural and spectroscopic investigations on new substituted 1,2,3-triazoles in the solid state.
A supramolecular adduct of tegafur and syringic acid: the first tegafur-nutraceutical cocrystal with perfected in vitro and in vivo characteristics as well as synergized anticancer activities
Authors: Yu Yue-Ming , Yu Ming-Chao , Wang Ling-Yang , Li Yan-Tuan , Wu Zhi-Yong , Yan Cui-Wei
Published: August 2020

The in vitro and in vivo properties as well as synergistic antitumor activities of the first tegafur-nutraceutical cocrystal are reported.
Biosynthetically grown dendritic silver nanostructures for visible Surface Enhanced Resonance Raman Spectroscopy (v-SERRS)
Authors: Juneja Subhavna , Bhattacharya Jaydeep
Published: August 2020

A simple approach to achieve high SERS enhancement for bio-analyte detection at visible wavelength through a resonance Raman (RR) effect has been proposed in this study.
Trivalent metal ions promote the malic enzyme-catalyzed building of carbon–carbon bonds from CO2and pyruvate
Authors: Katagiri Takayuki , Amao Yutaka
Published: August 2020

ME is an attractive biocatalyst for building carbon–carbon bonds through carboxylation of pyruvate with CO2. The carboxylation of pyruvate with CO2was promoted by adding a trivalent metal ion. In particular, Al3+accelerates ME-catalyzed carboxylation of pyruvate with CO2.
Porphyrin-based metal–organic framework catalysts for photoreduction of CO2: understanding the effect of node connectivity and linker metalation on activity
Authors: Jin Jiarui
Published: August 2020

The synergistic effect of linker defects and metalation on the photocatalytic activities of porphyrin-based MOFs.
Theoretical investigation on catalytic mechanisms of oxygen reduction and carbon monoxide oxidation on the MnNx system
Authors: Luo Mingming , Liang Zhao , Chen Mingwei , Liu Chao , Qi Xiaopeng , Peera Shaik Gouse , Liu Juan , Liang Tongxiang
Published: August 2020

Integrating all structures of the MnNx system, MnN4 shows the best ORR and COOR catalytic performance.
Digital counting of nucleic acid targets using solid-state nanopores
Authors: Beamish Eric , Tabard-Cossa Vincent , Godin Michel
Published: August 2020

A nanostructure-based assay for miRNA detection and quantification using solid-state nanopores.
Fractionation of block copolymers for pore size control and reduced dispersity in mesoporous inorganic thin films
Authors: Alvarez-Fernandez Alberto , Reid Barry , Suthar Jugal , Choy Swan Yia , Jara Fornerod Maximiliano , Mac Fhionnlaoich Niamh , Yang Lixu , Schmidt-Hansberg Benjamin , Guldin Stefan
Published: August 2020

Inorganic mesoporous coatings find widespread application. In many cases, control over the pore dimensions is of paramount importance. To this end, we establish a powerful route to pore size and dispersity control.
Twisted 1T TaS2 bilayers by lithiation exfoliation
Authors: Li Hui , Liu Pan , Liu Qi , Luo Ruichun , Guo Chenguang , Wang Ziqian , Guan Pengfei , Florencio Aleman Christopher , Huang Fuqiang , Chen Mingwei
Published: August 2020

Atomic-scale observations reveal the existence of eight twist commensurate configurations in twisted 1T TaS2 bilayers synthesized by lithiation exfoliation.
Biselyngbyolides A & C: their total synthesis and anticancer activities
Authors: Paul Debobrata , Sahana Moinul Haque , Mandal Pratiti , Chakrabarti Partha , Goswami Rajib Kumar
Published: August 2020

Convergent strategies have been developed for the total synthesis of biselyngbyolides A & C, and their anticancer activities were described.
Photoinduced iodine-mediated tandem dehydrogenative Povarov cyclisation/C–H oxygenation reactions
Authors: Schendera Eva , Villinger Alexander , Brasholz Malte
Published: August 2020

Visible light and iodine mediate dehydrogenative imine [4+2]-cycloaddition/C–H oxygenation reactions to furnish highly functionalised 3-quinolones under metal-free conditions.
Chemoselective activation of ethyl vs. phenyl thioglycosides: one-pot synthesis of oligosaccharides
Authors: Mc Carthy Cian , Zhu Xiangming
Published: August 2020

Ethyl thioglycosides could be selectively activated in the presence of phenyl thioglycosides carrying the same or even more armed protecting group pattern.
Stimuli-responsive degrafting of polymer brushes via addressable catecholato-metal attachments
Authors: Agergaard Asger Holm , Pedersen Steen Uttrup , Birkedal Henrik , Daasbjerg Kim
Published: August 2020

Surface attached catecholato-metal complexes serve as polymer brush initiators with well-defined densities and enable stimuli-responsive degrafting of polymer brushes.
Copper-catalyzed 1,1-alkynylalkylation of alkynes: access toward conjugated enynes
Authors: Lv Y. , Wang Y. , Pu W. , Zhu X. , Wu N. , Zhao Y.
Published: August 2020

A copper-catalyzed 1,1-alkynylalkylation of alkynes with α-haloacetamides for the construction of conjugated enynes has been developed.
Objective quantification of surface roughness parameters affecting superhydrophobicity
Authors: Cho Yoonkyung , Park Chung Hee
Published: August 2020

This study proposes new optical roughness parameters that can be objectively quantified using image processing techniques, and presents an analysis of how these parameters are correlated with the degree of superhydrophobicity.
Side-by-side comparison of Notch- and C83 binding to γ-secretase in a complete membrane model at physiological temperature
Authors: Dehury Budheswar , Tang Ning , Mehra Rukmankesh , Blundell Tom L. , Kepp Kasper P.
Published: August 2020

Distinct membrane dynamics and conformations of C83- and Notch-bound γ-secretase may aid the development of Notch-sparing treatments of Alzheimer's disease.
Biofilm formation potential and chlorine resistance of typical bacteria isolated from drinking water distribution systems
Authors: Zhu Zebing , Shan Lili , Hu Fengping , Li Zehua , Zhong Dan , Yuan Yixing , Zhang Jie
Published: August 2020

Biofilms are the main carrier of microbial communities throughout drinking water distribution systems (DWDSs), and strongly affect the safety of drinking water.
Development of a portable lab-on-a-valve device for making primary diagnoses based on gold-nanoparticle aggregation induced by a switchable linker
Authors: Hahn Jungwoo , Kim Eunghee , Han Hyebin , Choi Young Jin
Published: August 2020

We have developed a low-cost, portable lab-on-a-valve (LOV) integrated microdevice for the detection of pathogens in primary-diagnosis settings.
Temperature-dependent changes in the molecular orientation and visible color of phthalocyanine films
Authors: Furuyama Taniyuki , Uchiyama Shiori , Chikamatsu Tatsuki , Horikawa Takafumi , Maeda Hajime , Segi Masahito , Takahashi Hiromi , Taima Tetsuya
Published: August 2020

A simple phthalocyanine zinc complex exhibits a visible color change in response to weak external stimuli, i.e., changes in solvent and temperature.
Correction: Rubia tinctorum root extracts: chemical profile and management of type II diabetes mellitus
Authors: Eltamany Enas E. , Nafie Mohamed S. , Khodeer Dina M. , El-Tanahy Aya H. H. , Abdel-Kader Maged S. , Badr Jihan M. , Abdelhameed Reda F. A.
Published: August 2020

Correction for ‘Rubia tinctorum root extracts: chemical profile and management of type II diabetes mellitus’ by Enas E. Eltamany et al., RSC Adv., 2020, 10, 24159–24168, DOI: 10.1039/D0RA03442H.
Exploring modular reengineering strategies to redesign the teicoplanin non-ribosomal peptide synthetase
Authors: Kaniusaite Milda , Goode Robert J. A. , Tailhades Julien , Schittenhelm Ralf B. , Cryle Max J.
Published: August 2020

Redesign of the non-ribosomal peptide synthetase (NRPS) from teicoplanin biosynthesis has been extensively investigated via domain exchange, interface reengineering and through engineering communication between isolated NRPS modules.
Spatial confinement alters the ultrafast photoisomerization dynamics of azobenzenes
Authors: Otolski Christopher J. , Raj A. Mohan , Ramamurthy Vaidhyanathan , Elles Christopher G.
Published: August 2020

Ultrafast transient absorption spectroscopy reveals new excited-state dynamics following excitation of trans-azobenzene (t-Az) and several alkyl-substituted t-Az derivatives encapsulated in a water-soluble supramolecular host–guest complex.
First-row transition metal oxide oxygen evolution electrocatalysts: regulation strategies and mechanistic understandings
Authors: Zhang Lihua , Fan Qun , Li Kai , Zhang Sheng , Ma Xinbin
Published: August 2020

Regulation strategies and mechanistic understandings of first-row transition metal oxide-based oxygen evolution electrocatalysts.
Integrative genomics analysis identifies five promising genes implicated in insomnia risk based on multiple omics datasets
Authors: Sun Haozhen , Zhang Jianhua , Ma Yunlong , Liu Jingjing
Published: August 2020

In recent decades, many genome-wide association studies on insomnia have reported numerous genes harboring multiple risk variants. Nevertheless, the molecular functions of these risk variants conveying risk to insomnia are still ill-studied. In the present study, we integrated GWAS summary statistics (N=386,533) with two independent brain expression quantitative trait loci (eQTL) datasets (N=329) to determine whether expression-associated SNPs convey risk to insomnia. Furthermore, we applied numerous bioinformatics analyses to highlight promising genes associated with insomnia risk. By using Sherlock integrative analysis, we detected 449 significant insomnia-associated genes in the discovery stage. These identified genes were significantly overrepresented in six biological pathways including Huntington’s disease (P=5.58 × 10−5), Alzheimer’s disease (P=5.58 × 10−5), Parkinson’s disease (P=6.34 × 10−5), spliceosome (P=1.17 × 10−4), oxidative phosphorylation (P=1.09 × 10−4), and wnt signaling pathways (P=2.07 × 10−4). Further, five of these identified genes were replicated in an independent brain eQTL dataset. Through a PPI network analysis, we found that there existed highly functional interactions among these five identified genes. Three genes of LDHA (P=0.044), DALRD3 (P=5.0 × 10−5), and HEBP2 (P=0.032) showed significantly lower expression level in brain tissues of insomnic patients than that in controls. In addition, the expression levels of these five genes showed prominently dynamic changes across different time points between behavioral states of sleep and sleep deprivation in mice brain cortex. Together, the evidence of the present study strongly suggested that these five identified genes may represent candidate genes and contributed risk to the etiology of insomnia.
Bioinformatics analysis of prognostic value of PITX1 gene in breast cancer
Authors: Wang Qiaoyun , Zhao Shuai , Gan Lei , Zhuang Zhixiang
Published: August 2020

Background: Paired-like homeodomain transcription factor 1 (PITX1) participates in miscellaneous biological processes including cell growth, development, progression and invasion in various malignant tumors. However, the analysis of the association between PITX1 expression and the survival in breast cancer remains unclear. Methods: Clinical prognostic parameters and survival data related to PITX1 in breast cancer patients were performed using the bioinformatic analysis including Oncomine, Bc-GenExMiner v4.3, PrognoScan and UCSC Xena. Results: We found that PITX1 gene expression was significantly higher in different histological classification of breast cancer. The Scarff–Bloom–Richardson (SBR) grade, Nottingham prognostic index (NPI), estrogen receptor (ER) negative, epidermal growth factor receptor-2 (HER2) positive, lymph node positive, triple-negative status and basal-like status were positively correlated with PITX1 level, except for patients’ age and the progesterone receptor (PR) status. We have found that the increased PITX1 expression correlated with worse relapse-free survival, disease specific survival and overall survival. PITX1 was positively correlated with metastatic relapse-free survival and distant metastasis-free survival. We also confirmed positive correlation between PITX1 and the nucleotide-binding oligomerization domain 2 (NOD2). Conclusion: The lower expression of PITX1 was associated with better clinical prognostic parameters and clinical survival in breast cancer according to the bioinformatic analysis.
A brief note on the properties of linear pathways
Authors: Sauro Herbert M.
Published: August 2020

Linear metabolic pathways are the simplest network architecture we find in metabolism and are a good starting point to gain insight into the operating principles of metabolic control. Linear pathways possess some well-known properties, such as a bias of flux control towards the first few steps of the pathway as well as the lack of flux control at reactions close to equilibrium. In both cases, a rationale for these behaviors is given in terms of how elasticities transmit changes through a pathway. A discussion is given on the fundamental role that two reaction step sections play in a linear pathway when transmitting changes. For a pathway with irreversible steps, the deconstruction is straight forward and includes a product of local response coefficients that cascade along the pathway. When reversibility is included, the picture became more complex but a relationship in terms of the local response coefficients if derived that includes the reverse response coefficients and highlights the interplay between the forward and backward transmission of changes during a perturbation.
Metabolism
Authors: Judge Ayesha , Dodd Michael S.
Published: August 2020

Metabolism consists of a series of reactions that occur within cells of living organisms to sustain life. The process of metabolism involves many interconnected cellular pathways to ultimately provide cells with the energy required to carry out their function. The importance and the evolutionary advantage of these pathways can be seen as many remain unchanged by animals, plants, fungi, and bacteria. In eukaryotes, the metabolic pathways occur within the cytosol and mitochondria of cells with the utilisation of glucose or fatty acids providing the majority of cellular energy in animals. Metabolism is organised into distinct metabolic pathways to either maximise the capture of energy or minimise its use. Metabolism can be split into a series of chemical reactions that comprise both the synthesis and degradation of complex macromolecules known as anabolism or catabolism, respectively. The basic principles of energy consumption and production are discussed, alongside the biochemical pathways that make up fundamental metabolic processes for life.
Fremanezumab: a disease-specific option for the preventive treatment of migraine, including difficult-to-treat migraine
Authors: Friedman Deborah I. , Cohen Joshua M.
Published: August 2020

Fremanezumab is a fully humanized monoclonal antibody (IgG2Δa) that targets calcitonin gene-related peptide (CGRP), a key neuropeptide involved in the pathophysiology of migraine. Fremanezumab is approved for quarterly and monthly subcutaneous dosing for the preventive treatment of migraine in adults. The phase 3 clinical development program for fremanezumab aimed to evaluate the efficacy of this preventive treatment across different patient populations, including those with difficult-to-treat migraine. Two pivotal 12-week, phase 3, placebo-controlled studies investigated quarterly and monthly dosing of fremanezumab in participants with chronic migraine (HALO CM) and episodic migraine (HALO EM). The efficacy of fremanezumab was further explored in individuals with difficult-to-treat chronic or episodic migraine in the 12-week FOCUS study, which enrolled participants who had previously experienced an inadequate response to 2–4 pharmacological classes of migraine preventive medications. The long-term efficacy of fremanezumab was assessed in a 12-month long-term study (HALO LTS), which enrolled participants completing the 12-week HALO studies and new participants. Across these studies, treatment with fremanezumab dosed quarterly or monthly provided significant reductions in the frequency of migraine days, headache days of at least moderate severity, and migraine- and headache-related disability compared with placebo. Sustained improvements were seen with long-term fremanezumab treatment. Subgroup analyses of participants with difficult-to-treat migraine (those with comorbid depression, overuse of acute headache medications, and concomitant use of other migraine preventive medications) demonstrated the effectiveness of quarterly or monthly fremanezumab in these populations. Ongoing studies are further exploring the potential benefits of fremanezumab in difficult-to-treat migraine and other headache and pain disorders.
Effects of environment on stellar metallicity profiles of late-type galaxies in the CALIFA survey
Authors: Coenda Valeria , Mast Damián , Muriel Hernán , Martínez Héctor J.
Published: August 2020

Aims. We explore the effects of environment in the evolution of late-type galaxies by studying the radial profiles of light- and mass-weighted metallicities of galaxies in two discrete environments: field and groups.

Methods. We used a sample of 167 late-type galaxies with stellar masses of 9 ≤ log(M⋆/M⊙) ≤ 12 drawn from the Calar Alto Legacy Integral Field Area (CALIFA) survey. Firstly, we obtained light- and mass-weighted stellar metallicity profiles and stellar mass density profiles of these galaxies using publicly available data. We then classified them according to their environment into field and group galaxies. Finally, we studied the metallicity of galaxies in these two environments, including a comparison of the metallicity as a function of radius, at a characteristic scale, and as a function of stellar mass surface density. As metallicity depends on galaxy mass, we took special care throughout the study to compare, in all cases, subsamples of galaxies in groups and in the field that have similar masses.

Results. We find significant differences between group and field late-type galaxies in terms of their metallicity: group galaxies are systematically higher in metallicity than their field counterparts. We find that field galaxies, in general, have metallicity profiles that show a negative gradient in their inner regions and a shallower profile at larger radii. This is in contrast to the metallicity profiles of galaxies in groups, which tend to be flat in the inner regions and to have a negative gradient in the outer parts. Regarding the metallicity at the characteristic radius of the luminosity profiles, we consistently find that it is higher for group galaxies irrespective of galaxy mass. At fixed local stellar surface mass density, group galaxies are again higher in metallicity, also the dependence of metallicity on surface density is less important for group galaxies.

Conclusions. The evidence of a clear difference in metallicity between group and field galaxies as a function of mass, spatial scale, and local stellar mass density is indicative of the different evolutionary paths followed by galaxies in groups and in the field. We discuss some possible implications of the observed differences.
The Use of Higher than the Normal Field-forcing Ratio of Synchronous Machines from Energy Storage Systems to Increase the Reliability of Power Supply to Consumers in Centralized and Decentralized Zones
Authors: Bakhteev Kamil , Fedotov Alexander , Misbakhov Rinat
Published: August 2020

The paper presents the results of scientific research, firstly, the effectiveness of the use of energy storage systems as stabilizers of alternating current frequency as a part of gas piston installations in decentralized and centralized (operating in parallel with the power system) and their simultaneous use for excitation forcing of generators during voltage dips is proved, secondly, The efficiency of using increased field-forcing ratio of the synchronous generator of the gas piston installations is proved to improve the power quality of industrial consumers.
Methodology for Evaluation of District Heating Network Efficiency
Authors: Howard Daniel Anthony , Filonenko Konstantin , Busk Frederik Stjernholm , Veje Christian
Published: August 2020

The definition of overall district heating network performance indicators is under-investigated in the literature. This study reviews existing methods of performance estimation and develops a convenient methodology for an array of district heating networks applied to a Danish case study. Performances of the networks with state-of-art pipe transmission coefficients are compared to older traditional pipes using an effective average approach. The reported efficiencies and analysis of contributing factors show, that a single parameter is not sufficient to compare large-scale district heating systems and a multiparametric analysis must be employed. The effective average total heat transmission coefficient is evaluated based on the Technical Evaluation Factor and a multivariate regression is performed on typical sets of network parameters: pipe type, pipe series, pipe age, and operational temperature. The developed methodology is applied to testing an array of geographically independent district heating networks, pointing to possible performance bottlenecks, and discussing potential remedies.
Study on the Microgrid Pluripotent Complementary and Comprehensive Economic Optimization Planning Based on Virtual Energy Theory
Authors: Zhang Peng , Liu Na , Qu Bo-yang , Xiao Jun-ming , Lin Man-man
Published: August 2020

In this paper, a comprehensive economic allocation method based on virtual energy theory for microgrid complementary power supply is proposed, which is successfully applied to the multi energy complementary planning and comprehensive economic planning of an island microgrid. In order to evaluate and optimize the microgrid in the planning stage more objectively based on the characteristics of various combinations of renewable micro generation and flexible operation modes, a new method of the micro-grid comprehensive economic configuration and optimization of the distributed generation is proposed based on virtual energy theory. Firstly, the Micro-grid model structure based on the virtual energy theory is given. Secondly, the virtual energy conversion model of different distributed power generations is also studied. The micro-grid pluripotent complementary and comprehensive economic optimization model (PCCEP) based on virtual energy theory are reached too. Combined with a practical example, a PCCEP method of the micro-grid based on the Homer software platform is discussed. The case study indicates that the method can avoid the uncertainty of the decision-making factors and the subjectivity of expert evaluation. It is shown that the new method is a practical solution for microgrid comprehensive economic optimization planning.
A Recent Development of Monitoring Devices on Smart Grid
Authors: Awalin Lilik J. , Rahmat M. Khairil
Published: August 2020

Reliability, safe and continuous electrical power supply are always bound to disruption and the urged of the advancement in technology has made developed countries to keep align with their current system especially in electrical power network. High demand in electrical technology has made researchers to find approach in inventing a smart meter measurement as to which technically has a big impact towards consumers. Considering the revolution of IoT sensing technology could aid the communication between the operator and the grid efficiently. Thus, the advancement of technology will boost the performance in wide area monitoring system.
Polymyalgische Beschwerden: Steckt ein Tumor dahinter?
Authors: Gall Sabina , Tsiami Stella , Braun Jürgen
Published: August 2020

Anamnese Ein 61-jähriger Patient stellte sich mit Muskelschmerzen in Armen und Oberschenkeln, Gewichtsverlust von 10 kg in den letzten 3 Monaten und subfebrilen Temperaturen vor. Des Weiteren gab er abdominelle Schmerzen sowie eine Bauchumfangsvermehrung an.

Untersuchungen und Diagnose Es stellte sich der klinische Verdacht auf eine Polymyalgia rheumatica, basierend auf den Beschwerden des Patienten und den elevierten Entzündungsparametern, in Abwesenheit von typischen Antikörpern oder peripherer Synovitis. Die Gabe von 20 mg Prednison ergab eine Reduktion der klinischen Beschwerden sowie eine Normalisierung der Entzündungsparameter. Im MRT wurde eine lipomatöse Raumforderung im Abdomen mit Verdrängung der abdominellen Organe und der Organe im kleinen Becken festgestellt, ohne Zeichen einer Polymyalgia rheumatica. Histologisch konnte ein hoch differenziertes retroperitoneales Liposarkom diagnostiziert werden.

Therapie und Verlauf Nach der Diagnosestellung wurde der Tumor operativ entfernt, ohne anschließende Chemotherapie oder Radiatio, da es sich histologisch um einen gut differenzierten Tumor handelte.

Folgerung Bei Patienten mit polymyalgischen Beschwerden muss differenzialdiagnostisch auch an eine paraneoplastische Genese gedacht werden.
Neuromuskuläre Erkrankungen bei der HIV-Infektion
Authors: Hahn Katrin
Published: August 2020

Das Spektrum neuromuskulärer Erkrankung in HIV-infizierten Patienten ist breit und wird durch das Virus, eine sekundär induzierte Inflammation teilweise aber auch durch die antiretrovirale Therapie verursacht. Im Vordergrund der peripheren Komplikationen steht die HIV-assoziierte distal symmetrische Polyneuropathie (HIV-DSP). Ziel des Beitrags ist es, sowohl einen Überblick über relevante periphere Manifestationen der HIV-Infektion im niedergelassenen Bereich zu geben, als auch Handlungsempfehlungen für die Diagnostik und das Management von Patienten mit HIV-DSP vorzuschlagen.
Kohlendioxid-Bäder (CO2-Bäder)
Authors: Ranker Alexander
Published: August 2020

Seit dem 19. Jahrhundert werden Kohlensäurebäder als
natürliche Quellen zu therapeutischen Zwecken in Europa angewendet 1. Durch die artifizielle Herstellung von
CO2 konnte Anfang des 20. Jahrhunderts auch fernab von Naturquellen
therapiert werden. Die CO2-Therapie ist ein vielfältig
einsetzbares physikalisches Therapieverfahren. Es wird als Nassbad oder als Gasbad
angewendet.Das Wissen über Indikationen, Kontraindikationen, Wirkmechanismen sowie
Verordnung und Therapieüberwachung ist eine Kernkompetenz des Facharztes
für Physikalische und Rehabilitative Medizin (PRM).
Tibial Slope Correction as an Infratuberosity Closing-Wedge Extension Osteotomy in ACL-Deficient Knees
Authors: Dickschas Jörg , Strobel Michael J. , Weiler Andreas , Lobenhoffer Philipp , Simon Michael
Published: August 2020

ACL insufficiency can be caused by different reasons. Elevated posterior tibial slope is a deformity which is discussed to have relevant influence on the outcome of ACL surgery. A increased posterior tibial slope of 12° or more leads to significant more ACL insufficiency. The surgical therapy of this pathology is a high tibial extension osteotomy. Publications ashowing a clinical follow up and results of this surgery are rare. In this video the technique of a closed wedge high tibial extension osteotomy is shown. Osteosynthesis is performed with two screws and an anklestable plate osteosynthesis. An arthroscopy with bone graft filling of the femoral ACL tunnel is performed first, followed by filling of the tibial tunnel in an open approach.
Aktueller Forschungsstand zum pflanzlichen Antidepressivum Johanniskrautextrakt
Authors: Dillenburger Barbara , Häberlein Hanns , Kolb Christiane
Published: August 2020

Aus dem Zusammenspiel von neurobiologischen und psychosozialen Faktoren kennt man 3 für die Pathologie der Depression wesentliche Mechanismen. Neben der gut bekannten gestörten Neurotransmission resultiert die chronische Aktivierung der HPA-Achse in einer deregulierten Stressantwort, oxidativer Stress im Rahmen der Depression bedingt zusätzlich Inflammation und neurodegenerative Prozesse. In diesem Review wird der aktuelle Wissensstand zum Wirkspektrum des pflanzlichen Antidepressivums Johanniskrautextrakt dargelegt und mit synthetischen Antidepressiva verglichen. Auf der Basis aktueller Forschung lässt sich so ein Modell aus 3 wesentlichen Wirkmechanismen von Johanniskrautextrakt ableiten, über die – häufig analog zu klassischen chemisch-synthetischen Antidepressiva – in die Pathologie und Entwicklung der Depression eingegriffen werden kann.