bluuebunny/crossref_metadata_2025 huggingface dataset:
Persistent Apoptotic Enteropathy in an Individual With Marginal Cell Lymphoma
Authors: Yuquimpo Kyle , Nathani Piyush , Patel Harsh , Decino Andrea , Unegbu Fortune , Hamza Ameer
Published: September 2023

Apoptotic enteropathy is a histological finding of increased crypt apoptosis that is commonly associated with diarrhea. Several etiologies for this disease state including immunodeficiency, autoimmune, infection, hereditary, checkpoint inhibitors, immunosuppressants, and immunomodulators have been previously described. We describe an extremely rare case of a patient with marginal cell lymphoma treated with bendamustine, rituximab, and obinutuzumab presenting with severe, relapsing, chronic diarrhea with persistent apoptotic enteropathy of unknown etiology, despite hematological remission and discontinuation of treatment for 1 year.
Gastric Myeloid Sarcoma
Authors: Shaikh Abdullah S. , Almanza Huante Emmanuel , Taherian Mehran , Quesada Andres E. , Jabbour Elias J. , Thirumurthi Selvi
Published: September 2023

Most gastric cancers are adenocarcinomas, but other malignancies can arise in the stomach. Patients with leukemia may develop myeloid sarcoma (MS) in the gastrointestinal tract. Our patient was a 68-year-old woman who was initially diagnosed with acute myeloid leukemia and underwent a matched unrelated stem cell transplantation. She was in remission for 10 years before developing a rare case of gastric MS without acute myeloid leukemia. She had partial response to chemotherapy but ultimately died because of infection. Gastric MS has an incidence of less than 1%. Gastrointestinal involvement usually involves the small intestine and rarely the stomach.
Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency
Authors: Elkin Baila , Allende Daniela S. , Sengupta Shreya
Published: September 2023

Liver transplant is a rare phenomenon for pyruvate kinase deficiency (PKD)-related liver disease and can be mediated by multiple mechanisms. In this report, we present a 55-year-old man with PKD who had acute-on-chronic liver failure with kidney failure and marked hyperbilirubinemia. His liver disease was from recurrent cholangitis, cholestasis from hemolysis, and iron deposition (likely from both repeated transfusions in youth and chronic hemolysis), all consequences of his PKD. He received a liver transplant and had a good outcome. Our case highlights the mechanisms of liver injury in PKD and successful transplantation for this rare complication.
Optimization of Enzyme-assisted Extraction of Bioactive Peptides from Whiteleg Shrimp (Litopenaeus vannamei) Head Waste Using Box-Behnken Design
Authors: Nguyen Duong Canh , Nguyen Vy Le , Hong Nguyen Ha Vu
Published: September 2023

Whiteleg shrimp (Litopeneaus vannamei) processing lines discard huge quantities of head wastes, which are the protein-rich source. Enzymatic hydrolysis has been studied for decades to salvage discarded whiteleg shrimp head waste to produce high-added value products applicable to animal industry. Alcalase 2.5 L, which is widely applied on marine materials, was used to hydrolyze whiteleg shrimp head waste protein and then purified by cold absolute ethanol. Hydrolysis conditions including enzyme/substrate (E/S) ratio, incubation temperature and duration were preliminarily screened (E/S ratio 0–2.5%, temperature 50–70 °C, duration 30–90 min) before conducting optimization using Box-Behnken design. After optimization, collected protein hydrolysate reached an experimental yield of 61.64% on dry basis under the optimal conditions as treated by Alcalase 2.5 L at 0.9% E/S ratio and incubated at 62 °C for 65 min. Protein hydrolysate performed bioactivity including DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity (3.88 ± 0.10 mg Trolox equivalents g dry matter–1), reducing power (19.20 ± 0.52 mg Trolox equivalents g dry matter–1) and α-amylase inhibitory activity (10.74 ± 0.65% inhibition at 50 mg mL–1).
Forty-Seven Years of Environmental Management Accounting Research: A Bibliometric Analysis
Authors: DB Chetanraj , JP Senthil Kumar
Published: September 2023

Environmental sustainability is considered as responsible engagement with the environment in order to prevent the depletion or degradation of natural resources and ensure long-term environmental quality. Environmental management accounting (EMA) is a tool that aids in enhancing environmental performance and environmental information management. EMA is a growing topic, but there hasn't been a complete analysis to pull everything together and make sense of it all. By adopting bibliometric review, through performance analysis, and science mapping, our research fills in this research gap. Biblioshiny in R and VOS viewer is used for conducting data analysis. Through an extensive study of 1,075 documents, this study discloses the publication and citation trend, top influential authors, journals, publications, and top productive institutions and countries. The study also identifies topic trends through temporal analysis. Different thematic clusters are identified through bibliographic coupling and Co-occurrence of the author’s keywords (i.e. Social and environmental accounting, Environmental management accounting, Environmental performance, Carbon accounting, Sustainability, and sustainable development, Eco-system services, Environmental disclosure, and corporate social responsibility). Centrality measures are presented to show the impact of the author and keywords. The study concludes with suggestions for future study, and ways forward focusing on Circular economy, green accounting, material flow cost accounting, carbon accounting, sustainability, etc. The study is wholly dependent on the Scopus database, further studies can explore other databases like Web of science, google scholar, and others.
Top Management Support, Green Intellectual Capital and Green HRM: A Proposed Framework for Sustainability
Authors: ALKAF Abdur Rachman , YUSLIZA Mohd Yusoff , EHIDO Amauche Justina , SAPUTRA Jumadil , MUHAMMAD Zikri
Published: September 2023

Sustainability has become a crucial aspect of organisational strategy, with many organisations implementing sustainable actions to mitigate environmental effects and reinforce social responsibility. However, sustainability adoption in organisations may be challenging due to some factors including the lack of resources, conflicting priorities, and resistance to change. Considering that sustainability is a long-term agenda that requires continuous commitment and investment in human resources, companies should understand the drivers of their sustainability adoption to develop strategies that foster company longevity. This study discussed the resource-based view (RBV) theory that emphasises the strategic resources that could be utilised by an organisation to gain sustainable competitive advantage. A framework was proposed to demonstrate the ability of leveraging organisational key resources such as top management support (TMS), green intellectual capital (IC), and Green Human Resource Management (HRM) in promoting the adoption of sustainable practices in organisations. This research has contributed to the sustainability literature by establishing a unified framework that could be applied to assess the impacts of TMS, GIC, and Green HRM on sustainability and determine the ability of Green HRM to strengthen the relationships between TMS, GIC, and sustainability through mediation. The study results would assist the top management and policymakers in understanding the importance of their support towards sustainable development. The results would also enhance the understanding of the importance of continuous investment in green knowledge creation among employees to reap the benefits from GIC and Green HRM practices. Finally, researchers could adopt the proposed framework in future studies for further empirical explorations of the drivers of sustainability.
Integrated Urban Solid Waste Management: Knowledge, Practices, and Implementation
Authors: ALFARAS Riza Stephanie A.
Published: September 2023

The current study sets out to ascertain the residents of Kabankalan City's degree of solid waste management knowledge, practices, and implementation. This further established the relationship between their knowledge, practices, and degree of solid waste management program implementation. The researcher-made questionnaire was used to assess solid waste management practices and program implementation, while a modified version of the questionnaire from the study by Trondillo, et al. (2018) was utilized to assess knowledge levels. For the study, 365 residents of Kabankalan City were chosen at random. The primary analysis employed in this inquiry was the Pearson r correlation. According to the findings, locals have a fundamental grasp of and a modest level of practice with solid waste management. The city's solid waste management program was only partially implemented. Last but not least, the amount of knowledge and implementation was substantially correlated with the residents' solid waste management practices.
Issues Concerning the Improving Organizational and Legal Support of Victimological Prevention for Environmental Crimes
Authors: MALIKOV Dauren , SIDOROVA Natalya , ATAKHANOVA Saltanat , RAKHIMGULOVA Manshuk , MALIKOVA Sholpan , KUSSAINOVA Larissa
Published: September 2023

Environmental crimes have become a pressing issue in today's world, with the degradation of ecosystems, pollution, and climate change threatening the very foundation of our planet. These crimes not only harm the environment but also have adverse effects on individuals and communities. Recognizing the need for effective prevention strategies, victimological approaches have gained prominence. Victimology focuses on understanding and addressing the needs of the victims, aiming to prevent victimization and promote justice. This essay explores the importance of legal support in victimological prevention of environmental crimes and highlights the key measures required to achieve this goal.
Analysis of the Environment Impact on the Inclusion of Children with Special Educational Needs
Authors: TURLUBEKOVA Marzhan , BIRYUKOV Valeriy , MAGRUPOVA Zulfiya , KISHIBEKOVA Galiya , BUGUBAYEVA Roza
Published: September 2023

This paper highlights the critical role of the environment in facilitating the inclusion of children with special education needs (SEN) in educational settings. The physical environment, social interactions, curriculum, instructional practices, and policy frameworks all contribute to creating an inclusive environment. Considering and addressing the impact of these environmental factors, educators, policymakers, and school leaders can promote the successful inclusion and participation of children with SEN, ultimately enhancing their educational experiences and outcomes. Further research is needed to delve deeper into specific environmental factors and their interrelationships to develop comprehensive strategies for promoting inclusive education.
Impact of War on the Natural Preserve Fund: Challenges for the Development of Ecological Tourism and Environmental Protection
Authors: KUCHER Anatolii , HONCHAROVA Anna , KUCHER Lesia , BIELOBORODOVA Mariia , BONDARENKO Liudmyla
Published: September 2023

The global deterioration of the quality of the natural environment causes an increase in the importance of ecological tourism, primarily at the sites of the nature reserve fund. This paper is one of the first attempts to fill the existing gaps in the question of the impact of war on protected natural areas. The article determines the development trends, current state, and problems of the objects of the nature reserve fund in Ukraine in the conditions of unjustified full-scale russian military aggression and makes an approximate calculation of the damages caused as a result of hostilities. It was established that during 2012–2020, the number of objects of the nature reserve fund in Ukraine increased by 605 units or by 7.5 %; the area of these objects increased by 562,460.6 hectares or by 14.3 %. Due to russian military aggression, danger threatens 900 protected areas, which is 1.2 million hectares or about 30 % of the area of all protected areas of Ukraine. The damage calculation was carried out on the example of the Feldman EcoPark regional landscape park in the Dergachy district of the Kharkiv region. It was established that the approximate estimate of damages from the loss of ecosystem services of this landscape park as of 20.05.2022 was 16,979.5 thousand USD, including in terms of ecosystem services: (i) recreation and ecotourism – 13,846.2 thousand USD; (ii) air purification from solid fine particles and harmful gases – 272.1 thousand USD; (iii) biodiversity habitat – 2,861.3 thousand USD. In addition, the amount of damage caused to the regional landscape park due to the loss of animals, calculated based on special fees for calculating the amount of damage to the nature reserve fund, amounts to 63,350 USD. The determined damage estimates are preliminary and need to be clarified after the end of the war.
Sustainable Development and Environmental Tourism. The Case of Lake Karla – Thessaly, Greece
Authors: TRAKALA Georgia , MARTINIS Aristotelis , KARRIS Georgios , MINOTOU Charicleia , TSIROUKIS Achilleas
Published: September 2023

Sustainable development is the common ground between the three components: environment, economy, and society, which are also known as sustainability pillars. In this work, an attempt was made to investigate whether Lake Karla - Mavrovouni, supporting agriculture, biodiversity and cultural activities and being part of the Natura 2000 protected area network, in combination with the diverse topics of environmental education, can contribute for the sustainable development of local societies, with the contribution of the collective bodies of local self-government. For the holistic management of the protected area of the "Karla" lake, the managers must consider on the one hand the protection of the natural and cultural heritage and on the other hand the sustainable development of the area through the promotion of the natural and cultural heritage and the promotion of environmental tourism. For this purpose, managers need to know socio-economic and demographic characteristics of visitors. Here, questionnaire responses were used to investigate the profile, environmental perception, knowledge, and behavior of visitors. In total, more than 300 questionnaires were sent, and finally 161 questionnaires were fully answered, which constitute the research sample. The analysis of the results showed that the natural and cultural environment contribute to the sustainable development of the wider area of Lake Karla-Mavrovouni, highlighting through them serious advantages and opportunities to exploit the area by the local bodies.
Cambio, isomorfismo, calidad, y políticas públicas de evaluación y acreditación en la educación superior: Un caso en Colombia
Authors: Suárez-Landazábal Nelcy
Published: September 2023

Este artículo presenta los procesos de cambio como efectos de la implementación de las políticas públicas de evaluación y acreditación que de manera “voluntaria” son asumidos por las instituciones de educación superior colombianas. La investigación se abordó bajo la mirada del nuevo institucionalismo y mediante una investigación cualitativa, con un estudio de caso único en una institución de educación superior pública. Los resultados muestran los cambios a nivel de estrategia, estructura y cultura que operan desde lo institucional hacia lo organizacional que conduce a un isomorfismo institucional y competitivo y la dirige hacia un nuevo modelo de universidad que genera asimetrías en sus funciones misionales y cuestiona su identidad.
PYROLYZER PRODUCTION SYSTEM FOR WASTE MANAGEMENT USING GROUP TECHNOLOGY APPROACH
Authors: Rifai Achmad Pratama , Wibisono Ragil Aditya , Sari Dwi Kumala , Sari Wangi Pandan
Published: September 2023

Waste management methods in Indonesia largely rely on unsustainable practices such as open dumping and landfills which urgently need transformation. Pyrolysis is one alternative solution for waste problems as it can process waste into other products. As the existing production system was not set up to manufacture this machine, we proposed a production system to produce a pyrolizer so that a more effective and efficient production process can be achieved. In this study, we employed Group Technology approach using Rank Order Clustering (ROC) method to create cell manufacturing groups. Based on our evaluation on the shortest material movement, we produced 2 different cells to manufacture the pyrolyzer. Cell, I contained plate cutting, drilling, pipe cutting, and bending machines (M2, M5, M3, M4), whilst Cell 2 contained rolling and lathe machines (M1, M6).  It also contained main reactor, pyrolyzer reactor burner, middle condenser, upper access door, bottom access door, upper condenser, bottom condenser components (A, F, H, B, C, G, I). Out of the sixteen components to be made, seven components were in Cell I whereas the other nine were in Cell II (N, P, J, E, D, K , L, M, O) comprising burner case, access ladders, separators, firewalls, reactor base frames, condenser frames, gas piping, water piping, and sprinklers components. By applying this group technology method to the pyrolyzer production system, the production process could be carried out in a more efficient and organized manner.
Efektifitas Perpres No 35/208 untuk Mepercepat Pembangun PLTSa di Indonesia
Authors: Sudrajat Adang , - Syafrudin , Kusdiyantini Endang
Published: September 2023

Progres pembangunan Pembangkit Listrik Tenaga Sampah (PLTSa) di Indonesia sampai saat ini tidak terlalu signikan, padahal sudah banyak peraturan yang diterbitkan untuk mendukung percepatannya termasuk Peraturan Presiden RI yang diterbitkan beruntun, termasuk yang terakhir nomor 35 tahun 2018 untuk percepatan pembangunan  PLTSa di 12 kota besar yang volume sampahnya rata-rata sudah melebihi 1000 MT/hari. Sampai saat ini, baru PLTSa Benowo di Surabaya yang sudah sukses dibangun dan beroperasi secara komersial, sementara yang lainnya masih dalam tahap konstruksi 2 lokasi dan sisanya masih dalam proses perencanaan pengadaan dan penysunsan studi kelayakan. Mengapa pembangunan PLTSa ini berjalan sangat lambat, padahal tariff listrik yang dijual kepada PLN sudah ditetapkan jauh diatas tariff listrik PLN yang dijual kepada pelanggannya? Sudah banyak dilakukan penelitian terkait kendala dalam pembangunan PLTSa ini namun sampai saat ini belum memberikan dampak signifikan terhadap pelaksanaan pembangunannya. Mungkin masih banyak risiko yang harus dihadapi oleh Pemerintah Daerah, Pengembang maupun PLN dan belum ada mitigasi yang dalam kendali mereka sehingga mereka ‘enggan’ untuk aktif dalam proses pembangunan PLTSa ini. Untuk itu dilakukan kajian risiko terhadap pasal-pasal dalam Peraturan Presiden nomor 35 tahun 2018 untuk mengalwali proses penelitian ini, kemudian dilakukan konfirmasi melalui pertanyaan  yang dituangkan dalam kuisioner kepada Pemerintah Daerah, Pengembang dan PLN. Setelah dilakukan Analisa data hasil penelitian yang sudah divalidasi, disimpulkan kendala terhambatnya pembangunan PLTSa dimaksud dan disiapkan saran untuk mengatasi kendalanya
Analisis Perkiraan Kebutuhan Energi Sektor Rumah Tangga dengan Skenario BAU (Business As Usual) Menggunakan Perangkat Lunak LEAP (Low Emission Analysis Platform) di Provinsi Sumatera Selatan
Authors: Alqurni Wais , Hadiyanto Hadiyanto
Published: September 2023

Berdasarkan kebutuhan energi final pertahun yang mengalami peningkatan pada sektor rumah tangga perlu dikaji lebih dalam. Pengkajian ini bertujuan untuk memastikan pasokan energi primer aman dalam jangka panjang selama periode 2022-2040, dengan laju pertumbuhan penduduk sebesar 1,32 %  per tahun. Dampak dari pertumbuhan penduduk mengakibatkan total kebutuhan energi final dan primer dalam skenario BAU meningkat. Total kebutuhan energi final sektor rumah tangga meningkat dari 3,8 Juta SBM pada tahun 2021 menjadi 4,9 Juta SBM pada tahun 2040 atau meningkat rata-rata sebesar 5% per tahun. Sedangkan total kebutuhan energi primer yang dibutuhkan di tahun 2022 sebesar 6,1 Juta SBM dan di tahun 2040 sebesar 7,7 Juta SBM atau meningkat rata-rata sebesar 8,42% per tahun. Dalam sektor rumah tangga, energi final meliputi energi listrik dan LPG sedangkan energi primer merupakan energi yang ditransformasikan menjadi energi final ialah berupa gas sumber untuk LPG dan diesel sumber untuk pembangkit listrik tenaga diesel. Dengan demikian, apabila tidak ada kebijakan energi maka sesuai dengan hasil modeling yang dilakukan menggunakan model LEAP untuk skenario BAU dibutuhkan energi final berupa energi listrik dan LPG berturut-turut sebesar 2,5 dan 2,3 juta SBM pada tahun 2040. Sedangkan untuk kebutuhan energi primer gas dan diesel pada tahun yang sama ialah berturut-turut sebesar 2,3 dan 5,4 juta SBM.
Decreased plasma cartilage acidic protein 1 in COVID‐19
Authors: Johansson Mats W. , Balnis Joseph , Muehlbauer Laura K. , Bukhman Yury V. , Stefely Matthew S. , Overmyer Katherine A. , Vancavage Rachel , Tiwari Anupama , Adhikari Anish Raj , Feustel Paul J. , Schwartz Bradford S. , Coon Joshua J. , Stewart Ron , Jaitovich Ariel , Mosher Deane F.
Published: September 2023

Cartilage acidic protein‐1 (CRTAC1) is produced by several cell types, including Type 2 alveolar epithelial (T2AE) cells that are targeted by SARS‐CoV2. Plasma CRTAC1 is known based on proteomic surveys to be low in patients with severe COVID‐19. Using an ELISA, we found that patients treated for COVID‐19 in an ICU almost uniformly had plasma concentrations of CRTAC1 below those of healthy controls. Magnitude of decrease in CRTAC1 distinguished COVID‐19 from other causes of acute respiratory decompensation and correlated with established metrics of COVID‐19 severity. CRTAC1 concentrations below those of controls were found in some patients a year after hospitalization with COVID‐19, long COVID after less severe COVID‐19, or chronic obstructive pulmonary disease. Decreases in CRTAC1 in severe COVID‐19 correlated (r = 0.37, p = 0.0001) with decreases in CFP (properdin), which interacts with CRTAC1. Thus, decreases of CRTAC1 associated with severe COVID‐19 may result from loss of production by T2AE cells or co‐depletion with CFP. Determination of significance of and reasons behind decreased CRTAC1 concentration in a subset of patients with long COVID will require analysis of roles of preexisting lung disease, impact of prior acute COVID‐19, age, and other confounding variables in a larger number of patients.
Eine andere Art der Bestandspräsentation: Ausstellungen in Bibliotheken
Authors: Lenz Klaudia Charlotte
Published: September 2023

Ausstellungen sind längst nicht mehr nur in Museen und Kunstgalerien ein diskutiertes und stets weiterzuentwickelndes Thema. Auch in Bibliotheken wird sich dieser Art der Bestandspräsentation und ihrem Nutzen für das Bibliothekspersonal selbst, aber auch für die interessierten Besuchenden angenommen. Ausstellen in Bibliotheken heißt Hürden zu überwinden, weil diese oft neben den eigentlichen Aufgaben im Arbeitsalltag zusätzlich konzipiert und organisiert werden müssen und Bibliothekar*innen per se zunächst keine Ausstellungsexpert*innen sind.
Roundness and slenderness effects on the dynamic characteristics of spar-type floating offshore wind turbine
Authors: Adiputra Ristiyanto , Fauzi Faiz Nur , Firdaus Nurman , Suyanto Eko Marta , Kasharjanto Afian , Puryantini Navik , Erwandi Erwandi , Rasgianti Rasgianti , Prabowo Aditya Rio
Published: September 2023

Spar-type floating offshore wind turbine has been massively developed considering its design simplicity and stability to withstand the wave-induced motion. However, the variation of the local sea level and the readiness of supporting production facilities demand the spar design to adapt in a viable way. Considering this, the present article investigated how the slenderness (length over diameter ratio) and the roundness of cross section influence the hydrodynamic characteristics, which are the crucial parameters of floater performances. The OC3-Hywind spar-type floating platform was adapted as the reference model. The length of the reference floater was then varied with a ratio of 1.5, 2, 2.5, and 3 and the diameter was proportionally scaled to obtain constant buoyancy. The number of the sides which indicated the roundness of the cross section was varied to be 4, 6, 8, 10, 12, 14, and infinity (cylindrical shape). The analysis was conducted using potential flow theory in a boundary element method solver through an open-source code NEMOH. Initially, panel convergence was conducted and compared with the experimental results of the reference model to obtain the appropriate simulation settings before being used for the case configuration analysis. Results stated that the roundness effect with sides greater than 16 had little effect on dynamic characteristics. Meanwhile, the spar with the largest diameter was more stable against the translational motion.
Diagnostic properties of natriuretic peptides and opportunities for personalized thresholds for detecting heart failure in primary care
Authors: Harskamp Ralf E. , De Clercq Lukas , Veelers Lieke , Schut Martijn C. , van Weert Henk C.P.M. , Handoko M. Louis , Moll van Charante Eric P. , Himmelreich Jelle C.L.
Published: September 2023

Objectives

Heart failure (HF) is a prevalent syndrome with considerable disease burden, healthcare utilization and costs. Timely diagnosis is essential to improve outcomes. This study aimed to compare the diagnostic performance of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in detecting HF in primary care. Our second aim was to explore if personalized thresholds (using age, sex, or other readily available parameters) would further improve diagnostic accuracy over universal thresholds.

Methods

A retrospective study was performed among patients without prior HF who underwent natriuretic peptide (NP) testing in the Amsterdam General Practice Network between January 2011 and December 2021. HF incidence was based on registration out to 90 days after NP testing. Diagnostic accuracy was evaluated with AUROC, sensitivity and specificity based on guideline-recommended thresholds (125 ng/L for NT-proBNP and 35 ng/L for BNP). We used inverse probability of treatment weighting to adjust for confounding.

Results

A total of 15,234 patients underwent NP testing, 6,870 with BNP (4.5 % had HF), and 8,364 with NT-proBNP (5.7 % had HF). NT-proBNP was more accurate than BNP, with an AUROC of 89.9 % (95 % CI: 88.4–91.2) vs. 85.9 % (95 % CI 83.5–88.2), with higher sensitivity (95.3 vs. 89.7 %) and specificity (59.1 vs. 58.0 %). Differentiating NP cut-off by clinical variables modestly improved diagnostic accuracy for BNP and NT-proBNP compared with a universal threshold.

Conclusions

NT-proBNP outperforms BNP for detecting HF in primary care. Personalized instead of universal diagnostic thresholds led to modest improvement.
Finite 𝑝-groups of class two with a small multiple holomorph
Authors: Caranti A. , Tsang Cindy (Sin Yi)
Published: September 2023

We consider the quotient group

T
⁢

(
G
)

T(G)

of the multiple holomorph by the holomorph of a finite 𝑝-group 𝐺 of class two for an odd prime 𝑝.
By work of the first-named author, we know that

T
⁢

(
G
)

T(G)

contains a cyclic subgroup of order

p

r
−
1

⁢

(

p
−
1

)

p^{r-1}(p-1)

, where

p
r

p^{r}

is the exponent of the quotient of 𝐺 by its center.
In this paper, we shall exhibit examples of 𝐺 (with

r
=
1

r=1

) such that

T
⁢

(
G
)

T(G)

has order exactly

p
−
1

p-1

, which is as small as possible.
On the discrete Sobolev inequalities
Authors: Ngwamou Sedrick K. , Ndjinga Michael
Published: September 2023

We prove a discrete version of the famous Sobolev inequalities in ℝ
d
for d ∈ ℕ*, p ∈ [1, +∞[ for general non orthogonal meshes with possibly non convex cells. We follow closely the proof of the continuous Sobolev inequality based on the embedding of BV(ℝ
d
) into L
d/(d–1) by introducing discrete analogs of the directional total variations. In the case p ⩽ d (Gagliardo–Nirenberg inequality), we adapt the proof of the continuous case and use techniques from prior works. In the case p > d (Morrey’s inequality), we simplify and extend the proof of Porreta to more general meshes.
Crystal structure of poly[(μ-benzoato)-(μ-cis-4–hydroxy-D-proline)lithium], C12H14LiNO5
Authors: Yin Dejing , Wang Lingling , Yuan Zhenbo
Published: September 2023

(C12H14LiNO5)n, orthorhombic, P212121 (no. 19), a = 5.1481(4) Å, b = 8.9342(7) Å, c = 25.733(2) Å, Z = 4, V = 1183.57(16) Å3, R
gt(F) = 0.0539, wR
ref(F
2) = 0.1478, T = 100 K.
Biopolymer conjugation with phytochemicals and applications
Authors: Rana Anchal , Bhardwaj Sonal , Sharma Nandita
Published: September 2023

Sustainable and intelligent solutions are required to address the issues brought about by anthropogenic activity and the restricted availability of resources. Every nation is attempting to use each product from a natural resource in a necessary way in light of the current rise in environmental awareness. The bio-based biopolymers can be made from bacteria, animals, or plants. Biopolymers are a diverse class of compounds that are either produced by biological systems or synthesized from biological resources. Biopolymers are categorized as biodegradable and nonbiodegradable. Based on origin, they are further classified as being either bio based or fossil fuel based. Recently, biopolymers have gained immense recognition in different areas of biomedical field such as wound healing, burn dressing, tissue engineering, and fungal infection. These biodegradable polymer composites are effective at containing and releasing bioactive medications, such as probiotics, enzymes, pharmaceuticals, and nutraceuticals. Moreover, medicinal plants, a rich source of phytochemicals have been extensively used for their various therapeutic activities since ancient times and are being steadily providing the basis in modern drug delivery systems. There has been a lot of interest in the detection, separation, and use of dietary phytochemicals that may enhance human health and act as natural pigments, antioxidants, or antimicrobials well-being by preventing chronic illnesses like cancer, diabetes, obesity, and cardiovascular disorders. However, the delivery of these compounds for enhanced efficacy requires a rational approach. Therefore, the present chapter discuss about various sources of biopolymer, challenges, their construction mechanism, and their conjugation with phytochemicals as well as their applications.
How Does Temporal Blurring Alter Movement Timing?
Authors: Drążyk Dominika , Missal Marcus
Published: September 2023

Subjective uncertainty arises because the estimation of the timing of an event into the future is error prone. This impact of stimulus-bound uncertainty on movement preparation has often been investigated using reaction time tasks where a warning stimulus (WS) predicts the occurrence of a “go” signal. The timing of the “go” signal can be chosen from a particular probability distribution with a given variance or uncertainty. It has been repeatedly shown that reaction times covary with the shape of the used “go” signal distribution. This is interpreted as evidence for temporal preparation. Moreover, the variance of the response time should always increase with the duration of the delay between the WS and the “go” signal. This increasing variance has been interpreted as a consequence of the temporal “blurring” of future events (scalar expectancy). The present paper tested the validity of the temporal “blurring” hypothesis in humans with a simple oculomotor reaction time task where subjective and stimulus-bound uncertainties were increased. Subjective uncertainty about the timing of a “go” signal was increased by lengthening the delay between the WS and the “go” signal. Objective uncertainty was altered by increasing the variance of “go” signal timing. Contrary to temporal blurring hypotheses, the study has shown that increasing the delay between events did not significantly increase movement timing variability. These results suggest that temporal blurring could not be a property of movement timing in an implicit timing context.
A Novel Head-Fixed Assay for Social Touch in Mice Uncovers Aversive Responses in Two Autism Models
Authors: Chari Trishala , Hernandez Ariana , Portera-Cailliau Carlos
Published: September 2023

Social touch, an important aspect of social interaction and communication, is essential to kinship across animal species. How animals experience and respond to social touch has not been thoroughly investigated, in part because of the lack of appropriate assays. Previous studies that examined social touch in freely moving rodents lacked the necessary temporal and spatial control over individual touch interactions. We designed a novel head-fixed assay for social touch in mice, in which the experimenter has complete control to elicit highly stereotyped bouts of social touch between two animals. The user determines the number, duration, context, and type of social touch interactions, while monitoring an array of complex behavioral responses with high resolution cameras. We focused on social touch to the face because of its high translational relevance to humans. We validated this assay in two different models of autism spectrum disorder (ASD), theFmr1knock-out (KO) model of Fragile X syndrome (FXS) and maternal immune activation (MIA) mice. We observed higher rates of avoidance running, hyperarousal, and aversive facial expressions (AFEs) to social touch than to object touch, in both ASD models compared with controls.Fmr1KO mice showed more AFEs to mice of the same sex but whether they were stranger or familiar mice mattered less. Because this new social touch assay for head-fixed mice can be used to record neural activity during repeated bouts of social touch it could be used to uncover underlying circuit differences.

SIGNIFICANCE STATEMENTSocial touch is important for communication in animals and humans. However, it has not been extensively studied and current assays to measure animals' responses to social touch have limitations. We present a novel head-fixed assay to quantify how mice respond to social facial touch with another mouse. We validated this assay in autism mouse models since autistic individuals exhibit differences in social interaction and touch sensitivity. We find that mouse models of autism exhibit more avoidance, hyperarousal, and aversive facial expressions (AFEs) to social touch compared with controls. Thus, this novel assay can be used to investigate behavioral responses to social touch and the underlying brain mechanisms in rodent models of neurodevelopmental conditions, and to evaluate therapeutic responses in preclinical studies.
Glial Sphingosine-Mediated Epigenetic Regulation Stabilizes Synaptic Function inDrosophilaModels of Alzheimer's Disease
Authors: Yin Pengqi , Cai Yimei , Cui Tao , Berg Andrew J. , Wang Ting , Morency Danielle T. , Paganelli Paxton M. , Lok Chloe , Xue Yang , Vicini Stefano , Wang Tingting
Published: September 2023

Destabilization of neural activity caused by failures of homeostatic regulation has been hypothesized to drive the progression of Alzheimer's Disease (AD). However, the underpinning mechanisms that connect synaptic homeostasis and the disease etiology are yet to be fully understood. Here, we demonstrated that neuronal overexpression of amyloid β (Aβ) causes abnormal histone acetylation in peripheral glia and completely blocks presynaptic homeostatic potentiation (PHP) at the neuromuscular junction inDrosophila. The synaptic deficits caused by Aβ overexpression in motoneurons are associated with motor function impairment at the adult stage. Moreover, we found that a sphingosine analog drug, Fingolimod, ameliorates synaptic homeostatic plasticity impairment, abnormal glial histone acetylation, and motor behavior defects in the Aβ models. We further demonstrated that perineurial glial sphingosine kinase 2 (Sk2) is not only required for PHP, but also plays a beneficial role in modulating PHP in the Aβ models. Glial overexpression ofSk2rescues PHP, glial histone acetylation, and motor function deficits that are associated with Aβ inDrosophila. Finally, we showed that glial overexpression ofSk2restores PHP and glial histone acetylation in a genetic loss-of-function mutant of the Spt-Ada-Gcn5 Acetyltransferase complex, strongly suggesting thatSk2modulates PHP through epigenetic regulation. Both male and female animals were used in the experiments and analyses in this study. Collectively, we provided genetic evidence demonstrating that abnormal glial epigenetic alterations in Aβ models inDrosophilaare associated with the impairment of PHP and that the sphingosine signaling pathway displays protective activities in stabilizing synaptic physiology.

SIGNIFICANCE STATEMENTFingolimod, an oral drug to treat multiple sclerosis, is phosphorylated by sphingosine kinases to generate its active form. It is known that Fingolimod enhances the cognitive function in mouse models of Alzheimer's disease (AD), but the role of sphingosine kinases in AD is not clear. We bridge this knowledge gap by demonstrating the relationship between impaired homeostatic plasticity and AD. We show that sphingosine kinase 2 (Sk2) in glial cells is necessary for homeostatic plasticity and that glialSk2-mediated epigenetic signaling has a protective role in synapse stabilization. Our findings demonstrate the potential of the glial sphingosine signaling as a key player in glia–neuron interactions during homeostatic plasticity, suggesting it could be a promising target for sustaining synaptic function in AD.
Salience of Frequency Micro-modulations in Popular Music
Authors: Bürgel Michel , Siedenburg Kai
Published: September 2023

Singing voices attract auditory attention in music unlike other sounds. In a previous study, we investigated the salience of instruments and vocals using a detection task in which cued target sounds were to be detected in musical mixtures. The presentation order of cue and mixture signals influenced the detection of all targets except the lead vocals, indicating that listeners focus on voices regardless of whether these are cued or not, highlighting a unique vocal salience in music mixtures. The aim of the present online study was to investigate the extent to which phonological cues, musical features of the main melody, or frequency micro-modulation (FMM) inherent in singing voices contribute to this vocal salience. FMM was either eliminated by using an autotune effect (Experiment 1) or transferred to other instruments (Experiment 2). Detection accuracy was influenced by presentation order for all instrumental targets and the autotuned vocals, but not for the unmodified vocals, suggesting that neither the phonological cues that could provide a facilitated processing of speech-like sounds nor the musical features of the main melody are sufficient to drive vocal salience. Transferring FMM from vocals to instruments or autotuned vocals reduced the magnitude of the order effect considerably. These findings suggest that FMM is an important acoustical feature contributing to vocal salience in musical mixtures.
Constructing the Live Experience at Pop Music Concerts
Authors: Mulder Martijn , Hitters Erik
Published: September 2023

The aim of this study is to better understand the individual construction of the experience of liveness at pop music concerts and to add knowledge to the field of measuring audience experience in performing arts. The study is based on a mixed-methods methodology, designed to overcome the common difficulties related to researching visitor experiences of live music, and consists of a three-phase interpretative phenomenological analysis (IPA), made up of a pre-experience questionnaire, ecological momentary assessment (EMA), and participant observation during the experience and a post-experience interview. Based on the outcomes of the study, three main conclusions can be drawn: (1) the construction of the concert experience consists mainly of the interplay between the artist, the individual visitor, and his/her social company; the elements of collectiveness and the physical setting play a less decisive role in the concertgoer’s construction of the experience by our participants; (2) participating concertgoers use three (interconnected) narratives through which they construct their experience; and (3) the concept of absolute liveness is key to the construction of the concert experience, implying that concerts in physical co-presence have a strong distinctive value compared to mediated concerts.
RISING STARS: Role of MED12 mutation in the pathogenesis of uterine fibroids
Authors: Ishikawa Hiroshi , Kobayashi Tatsuya , Kaneko Meika , Saito Yoshiko , Shozu Makio , Koga Kaori
Published: September 2023

Graphical abstract

Uterine fibroids (UFs) are benign tumors arising from the uterus, characterized by accumulation of abundant extracellular matrix (ECM) and sex steroid-dependent growth. Women with symptomatic UFs have reduced quality of life and decreased labor productivity. Among the driver gene mutations identified in UFs, mutations in MED12, a component of the cyclin-dependent kinase (CDK) Mediator module, are the most common and observed in 50–80% of UFs. They are gain-of-function mutations and are more frequently observed in Black women and commonly observed even in small UFs. MED12 mutation-positive UFs (MED12-UFs) often develop multiple rather than solitary and have distinct gene expression profiles, DNA methylomes, transcriptomes, and proteomes. Gene expressions related to ECM organization and collagen-rich ECM components are upregulated, and impaired Mediator kinase activity and dysregulation of Wnt/β-catenin signaling are identified in MED12-UFs. Clinically, the UF shrinking effect of gonadotropin-releasing hormone agonists and ulipristal acetate is dependent on the MED12 mutation status. Understanding of characteristics of MED12-UFs and functions of MED12 mutations for UF tumorigenesis may elucidate the pathophysiology of UFs, leading to the development of new therapeutic options in women with symptomatic UFs.
El currículo oficial en las dos últimas reformas educativas en Colombia
Authors: Medina Cobo Orlando
Published: September 2023

En este escrito se pretende precisar la noción de currículo prescrito en las dos últimas reformas educativas en Colombia. La primera se extiende desde 1970 hasta inicios de la década de 1990 y la segunda a partir de 1991 hasta la fecha actual, periodos en los que la educación en el país ha presentado cambios orientados por instituciones estatales. Se considera fundamental aclarar la idea y el significado que abarca este término desde la prescripción que hace el Estado, como punto de partida para que las instituciones educativas organicen su propuesta formativa y, por lo tanto, como base para la práctica del maestro. Para lograr esta precisión conceptual se realiza una revisión documental principalmente de orientaciones provenientes de la política educativa, así como aportes realizados por expertos en este tema específico.
Políticas en la transición de los materiales curriculares: El caso de XarxaLlibres
Authors: Vidal Esteve María Isabel , San Martín Alonso Ángel , Peirats Chacón José
Published: September 2023

Se analiza una actuación de la administración sobre cofinanciación de los libros de texto mediante la iniciativa XarxaLlibres de la Comunidad Valenciana. Es un estudio de caso sobre cómo los distintos agentes se apropian de esta iniciativa en tres centros. Utilizando metodología cualitativa se emplean técnicas etnográficas para captar de modo natural la realidad, como entrevistas individuales, grupales, análisis documental y el diario de investigación. Entre las conclusiones destaca la desestructuración del modo convencional de acceso al conocimiento, fomentando alternativas diversas. Al focalizar la atención sobre la cofinanciación se descuidan otros aspectos como la participación o la igualdad de oportunidades, principal rasgo ideológico del programa. En definitiva, lo material es importante, pero aún más lo cultural y epistemológico que es sobre lo que hay que seguir indagando.
“Ladrones de la infancia”. La educación física española entre 1909 y 1914
Authors: Torrebadella Flix Xavier
Published: September 2023

En España a raíz de los sucesos de la Semana Trágica de Barcelona de 1910, con el pretexto de la protección a la infancia y el de la educación física, los sectores más conservadores y reaccionarios articularon instituciones regeneracionistas y patrióticas que modelaron las mentalidades y los cuerpos de la infancia socialmente desprotegida con finalidades productivas y violentas. Sobre este contexto se emplaza el objetivo de este artículo que se propone argumentar cómo este nacionalismo español estableció unas medidas pro-infancia con el propósito de concebir unos dispositivos disciplinarios para hacer de los impúberes un blindaje ofensivo de la unidad católica-nacional. Una metodología histórica-documental centrada en las fuentes primarias de la prensa de Madrid y Barcelona sitúan los textos originales en una hermenéutica crítica que se apoya en otros estudios relativos a la época y vinculantes al objeto de estudio. Se concluye que al llegar el 18 de julio de 1936 muchos de estos niños, ya hombres viriles, habían asimilado el marco mental guardián de la unidad territorial del Estado-católico y, también, a condenar a los que no eran como ellos, los “malos españoles” que había que eliminar.
Políticas conservadoras no Brasil: ameaças ao direito à educação e ataques à autonomia docente
Authors: Andrade Oliveira Dalila
Published: September 2023

O artigo discute algumas manifestações de políticas conservadoras no contexto escolar brasileiro que têm tentado interferir no trabalho docente. Por meio de campanhas que incitam os estudantes a vigiar seus professores contra qualquer expressão político-ideológica assim como aquelas relacionadas à gênero e sexualidade, esses movimentos têm tentado impor censura na sala de aula. O artigo procura analisar como três iniciativas recentes: o movimento Escola sem Partido, a campanha contra a chamada Ideologia de gênero e o programa de Militarização das escolas públicas têm tentado restringir a autonomia docente e colocado em risco o direito à educação, ambos garantidos em lei. O objeto em análise é autonomia docente e os fundamentos para as análises estão suportados em estudos e pesquisas desenvolvidos sobre a natureza do trabalho docente no Brasil e em outras realidades nacionais.
Derecho a la universidad y políticas educativas de (des)igualdad. El caso del Programa de Respaldo a Estudiantes de Argentina entre 2014 y 2019
Authors: Gluz Nora Beatriz , Ochoa Marcelo David
Published: September 2023

En este artículo se analiza la trayectoria del Programa de Respaldo a Estudiantes de Argentina (PROGRESAR) entre 2014 y 2019. La investigación propone, por un lado, reconstruir el diseño y conceptualización del programa desde su creación durante el último gobierno progresista de Fernández de Kirchner y sus transformaciones con el gobierno de derecha de Macri, a través de un análisis documental y entrevistas a funcionarios/as. Por otro, pretende estudiar los modos de apropiación de la política y las perspectivas sobre los cambios por parte de las y los perceptores, a partir de entrevistas grupales con estudiantes bajo programa de dos universidades públicas del conurbano bonaerense. Como parte de los primeros resultados, se sostiene que las nuevas derechas reconfiguraron los fundamentos de las políticas públicas al desplazar las intervenciones asentadas en un enfoque integral de derechos y de cobertura universal, hacia un sistema de becas restringidas a la ayuda económica de los más necesitados. Sostenemos como tesis que la coalición de derecha fundamentó los cambios en el mérito individual como nuevo principio de justicia cuyos efectos impactan en la implementación de la política analizada y en la autopercepción como sujetos del derecho a la universidad por parte de las y los jóvenes becarios/as.