bluuebunny/crossref_metadata_2025 huggingface dataset:
Legal behavior as human self-identification in the postmodern era
Authors: Rohozianskyi Vitalii
Published: November 2023

The article clarifies the philosophical and legal features of legal behavior as a factor of human self-affirmation in the postmodern era. Within the limits of philosophical and legal understanding, postmodernism should be considered in two aspects: conceptual-idealistic (as a theoretical concept) and nihilistic (as a modern social reality). According to the natural law theory, any behavior will be lawful if a person, exercising his natural rights, does not violate similar rights of other persons. The philosophical basis of this approach is the doctrine of freedom as the natural state of man and his (man's) free will. Freedom consists in the ability to do everything that does not harm another. Human freedom, accordingly, cannot be absolute, because it is limited by the same condition of other people. This actually reflects the postmodern philosophical and legal understanding of human behavior in a conceptual and idealistic aspect. Regarding the understanding of lawful human behavior in the nihilistic plane of postmodernity, this is a conformist philosophical and legal concept. According to which a person's behavior is subject to new social standards and requirements, and can also be subjected to psychological pressure and manipulation by others who have stronger worldview and value beliefs. It is concluded that legal behavior is a factor of self-affirmation of a person in the postmodern era, self-identifies him as a person in social reality. Law has value, as it contributes to self-determination and self-realization of a person, provides new opportunities for individual and social development. The importance of the value of law for "postmodern man" and "postmodern society" is undeniable. In the conditions of a hyper-dynamic pace of life, conceptual chaos and radical pluralism, law remains a fundamental value for self-identification, self-creation, self-presentation and preservation of human self-worth.
The philosophy of a law that doesn`t work
Authors: Tokarska Antonina , Dobryanskyi Markiyan
Published: November 2023

Abstract. The relevance of the study lies in the study of negative trends of real reality in the life of Ukrainian society against the background of the international authority of our state. The problems of not fully effective operation of the law during the period of martial law and the inconsistency of the existing mechanisms for the protection of human rights and freedoms to the needs of citizens were considered. An overview of the restrictions that were introduced during the legal regime of martial law was made. Attention is focused on the unbalanced distribution of the role of the parliamentary-presidential model of interaction of all branches of government in society: the President, the National Security and Defense Council, as well as the Cabinet of Ministers of Ukraine for the purpose of legal regulation of public life in Ukraine. The research was carried out on the basis of a sociological survey conducted in order to determine the assessment of the legal ideology of martial law (128 people). Existing legislative conflicts in the sphere of restriction of the right to freedom of speech and security are highlighted.
Protection of computer software in the copyright system
Authors: Rymarchuk Rimma
Published: November 2023

Software development in recent decades has demonstrated a pace of change not seen since the Industrial Revolution. Software affects almost every aspect of human life in all parts of the world. From an intellectual property rights perspective, discourse and debate focus not only on how software should be protected, but also on a host of issues that reflect the many aspects that software plays in the digital distribution of creative content. A further issue concerning the concept of “computer program” is whether the images generated on screens as a result of the operation of a program (for example, in the case of video games) may or should be regarded as parts of a “computer program”. It is possible to find certain views according to which an affirmative answer should be given to this question, and such views have been accepted exceptionally even at the level of national legislation, but the dominant opinion, as well as the dominant position under national laws, is that the images generated by a computer program in the form of screen display go beyond the concept of computer programs proper. The concept of “computer program” under Article 4 of the WCT also does not extend to the images generated by computer programs on screens. Until recently, unauthorized copying of software required the physical exchange of floppy disks, CDs, or other hard media. But software piracy has become much easier with the spread of the Internet, becoming faster and cheaper. The Internet allows products to move from computer to computer without transactions on hard media and with little risk of detection. Some piracy schemes may even involve computers without the owner's knowledge. Piracy that once required understanding complex computer codes can now be done with the click of a mouse on peer-to-peer networks, through mail-order and auction sites, newsgroups, or even as simple email attachments. Strong action at the local, national and international levels is needed to counter these dangerous trends.
Ways to solve the problem of preventing criminal offenses in relation to individual participants in criminal proceedings in Ukraine
Authors: Huzela Mykhailo
Published: November 2023

The article is devoted to ways of solving the problem of prevention of criminal offenses in Ukraine regarding individual participants in criminal proceedings, in particular, witnesses and victims in the context of ensuring their safety in criminal proceedings. Based on the study of foreign experience in solving this problem in criminal proceedings, it was established that the key features of the procedural status of witnesses and victims, which distinguish them from other participants in criminal proceedings, in particular, the suspect, the accused, are the presence, respectively, of a statutory duty or right to provide independent impartial testimony on the merits of criminal proceedings, as well as the obligation to provide truthful testimony. However, such statutory obligations of the specified participants in criminal proceedings must be confirmed by appropriate guarantees of their safety from the legislator. Their essence as subjects of the criminal process, who are carriers of evidentiary information, emerges from a theoretical study of the scientific positions of individual scientists regarding the purpose and grounds of protection and ensuring their safety, as well as an analysis of the norms of criminal and criminal procedural legislation in force in Ukraine, which are designed to implement ways prevention of the possibility of committing criminal offenses against the witness and the victim in the context of ensuring their protection and safety in criminal proceedings. An analysis of the positive for Ukraine experience of some foreign states in building a system of protection and ensuring the safety of the mentioned participants in the process in order to prevent criminal offenses against them is also presented. The use of international experience is invaluable for the urgent need to improve the institution of prevention of criminal offenses against participants in criminal proceedings in Ukraine. After all, today in Ukraine there is an urgent need to develop an effective system of protection and protection of analyzed participants in criminal proceedings, given the lack of a mechanism for implementing the relevant legislation.
Differences in the criminal law regulations of liability for fraud in the legislation of some foreign countries
Authors: Humin Oleksii , Kozlov Vladyslav
Published: November 2023

Abstract. During the last decade, there has been an interest in comparative legal studies concerning the science of criminal law. A significant change in the conditions of social life and the desire to adhere to the principles accepted by the peoples of developed countries require the study of foreign experience and sometimes taking information from international law. Comparative research makes it possible to reveal and take into account other people's mistakes and achievements when solving questions about criminality and the punishment of specific acts, helps to understand the role and significance of criminal law as a tool of social regulation. Recently, comparative legal studies of norms concerning property criminal offenses have appeared in science, but they pay unjustifiably little attention to the investigation of fraud. In this article, without pretending to be an exhaustive analysis, we will focus attention on the most significant differences in the criminal law regulation of liability for fraud in the legislation of some foreign countries. No society can exist without property, which, being the economic basis, largely determines political, moral, legal, and other relations. According to the modern idea of the system of social values, the right to property is regarded as the greatest of the social benefits of an individual. Therefore, encroachments on these benefits are encroachments on personality. Fraud occupies a special place among criminal offenses against property. Even though in quantitative terms, fraudulent crimes are inferior to theft and robbery, in terms of the growth rate of the number of registered cases of fraud, this type of criminal offense is significantly ahead of other crimes against property. A feature of foreign legislation is the presence, along with the general regulation concerning liability for fraud, of an extensive system of special regulations concerning liability for fraud in financial markets, in insurance, lending, and circulation of actual objects, goods, and services.
Analysis of Problem Based Learning Models to Improve Creative Thinking Ability of Senior High School Students on Momentum and Impulse Topic
Authors:   Magister of Physics’ Universitas Negeri Malang, Indonesia, Permana I Putu yogi Setia , Parno Parno ,   Department of Physics’ Universitas Negeri Malang, Indonesia, Purwaningsih Endang ,   Department of Physics’ Universitas Negeri Malang, Indonesia, Ali Marlina ,   Magister of Physics’ Universitas Negeri Malang, Indonesia
Published: November 2023

Schools must have the 4C abilities, notably creative thinking, to keep up with the advancement of science and technology in the 21st century's educational institutions. The ability to think creatively strives to involve activities, analyze, synthesize, generate conjectures, create something new, and utilize the knowledge acquired in practical ways. Some studies show that students' creative thinking skills in momentum and impulse materials are not optimal. One of the factors that cause students' low creative thinking skills is the learning process. This study aims to provide an overview of students' creative aptitudes on momentum and impulse topics. This study used a mixed method with an embedded experimental design. At SMA 1 Menggala in Lampung, this study was carried out. 28 students of class X MIPA 2 involved in the study were taken as samples with a saturated sampling technique. For this study, the students participated in tests and interviews. Of the four essay questions on momentum and impulse that made up the creative thinking ability exam each validity value (0.686) and reliability (0.610) had a high category. A creative mind is characterized by fluency, flexibility, originality, and elaboration. Problem-based learning models can help students' creative thinking skills, according to the findings of research on the subject. According to the results of the investigation, most students have a high level of creativity on the indicator of fluency. The problem-based learning model is successful in enhancing the ability to think creatively and is expected to be applied in further research on different topics.
The Influence of Self-Assessment on Cognitive Learning Outcomes of High School Students in the Topic of Linear Motion Kinematics
Authors:   Universitas Negeri Malang Indonesia  Department Physics Education, Khusaini Khusaini , Sania Hilma Azza ,   Universitas Negeri Malang Indonesia  Department Physics Education, Munfaridah Nuril ,   Universitas Negeri Malang Indonesia  Department Physics Education
Published: November 2023

Linear motion kinematics is one of the fundamental prerequisites for further knowledge acquisition, but students often face difficulties in comprehending this topic, which consequently impacts their cognitive learning outcomes. This research aims to investigate the influence of self-assessment on the cognitive learning outcomes of high school students in the subject of linear motion kinematics. This study used a quantitative approach with a group post-test design. Sampling was conducted through random sampling, with 33 students from Class X IPA A assigned as the experimental group and 32 students from Class X IPA B as the control group. The research instruments include a multiple-choice test sheet consisting of 12 questions and a self-assessment sheet. Data analysis commenced with prerequisite testing, revealing non-normally distributed data, thus necessitating the application of the Mann-Whitney test for analysis. The research findings revealed a significant difference between the experimental and control groups regarding cognitive learning outcomes. The self-assessment conducted by some students is not entirely in line with their cognitive learning outcomes, as evidenced when students respond as very understanding in self-assessment but then, when working on confirmation questions with the same indicators, they provide less accurate answers. Therefore, it is important to enhance the implementation of self-assessment in schools. Furthermore, future researchers should consider developing self-assessment tools for other different physics topics.
Ethnic, National and Identity Demands in Iran on the Axis of Justice and Development: A Grounded Theory Method Study among Five Major Ethnic Groups
Authors: Ahmady Kameel
Published: November 2023

The identity/ethnic diversity in Contemporary Iran has co-occurred with the development of globalization processes and brought about interethnic conflict, Orientation of identity and seeking justice to eradicate discrimination and inequality in achieving social development. This is the issue that the present research has sought to investigate among the Persian (fars), Azeri, Kurd, Arab, and Baloch in Iran. The article has adopted a hybrid qualitative approach (GT), in thirteen provinces of Iran to extract and classify data in the following areas: religious identity and national identity, interethnic cultural borders, ethnic and national movement dead-end, and a peace-oriented approach to resolving the crisis.
Academic Search Engine Optimization: Improving visibility and accessibility of scientific publications
Authors: Tikhonova E. V.
Published: November 2023

A text of a scientific paper, adapted for academic search engine optimization (ASEO) tools, enables it to achieve a high ranking in the context of search queries in databases and other search systems. As a result, the article appears in more search queries, receiving more views, downloads, and citations. ASEO not only promotes the fundamental discoverability of the article but also optimizes its metadata. Carefully formulated titles, keywords, and abstracts increase the interest of all categories of potential readers in the paper content, facilitating a deeper understanding of the essence of the described research and the authors’ motivation for conducting it. The purpose of the presented paper is to describe the ASEO tools, enabling the author to optimize the manuscript text for its post-publication promotion. The paper presents basic information about ranking mechanisms, comments on the advantages and limitations of ASEO optimization. It will be useful not only to authors of scientific publications but also to editors of scientific journals who are interested in increasing their visibility.
The Contribution of Artificial Intelligence to Stimulating the Innovation of Educational Services and University Programs in Public Administration
Authors:   Professor, Department of Administration and Public Management, Faculty of Administration and Public Management, Bucharest University of Economic Studies, Bucharest, Romania, POPESCU Ruxandra-Irina , SABIE Oana Matilda ,   Associate Professor, Department of Administration and Public Management, Faculty of Administration and Public Management, Bucharest University of Economic Studies, Bucharest, Romania, TRUȘCĂ Marian Iulian ,   Student, Master’s Program in Human Resource Management in the Public Sector, Faculty of Administration and Public Management, Bucharest University of Economic Studies, Bucharest, Romania
Published: November 2023

In the new contemporary pandemic paradigm, higher education in public administration and beyond knows challenges, barriers, and opportunities for the academic process. Shocks, environmental changes and physical distancing in recent years have led to the implementation of efficient solutions in educational services, based on artificial intelligence (AI). Thus, in the global academic landscape, many international universities have adopted a ‘chatbot’, a digital interface designed to stimulate conversation with people. Modern algorithmic communications have effects, such as: increasing the number of enrollments in public administration programs, improving academic experience and active student participation, while reducing administrative tasks on university staff. This paper aims to provide a glimpse on the perceptions of the potential impact of conversational artificial intelligence on public administration (PA) programs from universities and to reflect on its implications for university leaders and staff work and also on students’ engagement. The paper will focus on how AI tools will help university programs to be more effective, and how technology will support the limited human resources in this sector. In order to gather the data for this research, the interview was used as well as case studies from international universities that have implemented a chatbot. The research findings capture technological and digital advances that will continue to shape the higher education landscape and its curricula, especially in PA programs. As a result, leaders will need to monitor how artificial intelligence, in particular conversational agents, influences universities’ images; attraction and retention for students in PA programs and other important partners; staff productivity, and how to be more proactive in initiating pilot projects. This is one of the few publications that looks at the expectations for conversational AI in higher education today. In this sense, implementing a chatbot can be a competitive advantage in a market where modern technologies weigh heavily and make a difference.
Who Runs Public Administration? A Longitudinal Study of Technocratic Ministerial Appointments in Post-Communist Romania (1991–2021)
Authors:   PhD, Lecturer, Department of Public Administration, Faculty of Business and Administration, University of Bucharest, Bucharest, Romania Board Member, National Council for Combating Discrimination, Romania, RAIU Cătălin , MINA-RAIU Laura ,   PhD, Associate Professor, Department of Administration and Public Management, Faculty of Administration and Public Management, Bucharest University of Economic Studies, Bucharest, Romania
Published: November 2023

Starting from the traditional public administration dichotomy ‘power versus knowledge’, concerned with the cleavage between politicians and bureaucrats, this paper’s main purpose is to reframe a classic theoretical model, by placing the spotlight on a new, under-conceptualized public sector actor: the technocrat. Second, the paper performs empirical research starting from an own-build comprehensive database that includes all the ministers appointed in the Romanian Government during a 30-year timeframe (October 1991-November 2021). In spite of being a rather young democracy with a communist public sector legacy, research findings indicate that in Romania we can clearly identify patterns similar to other European countries (primarily Italy), consisting of appointing technocrats to the cabinet. Such nominations are discussed in correlation with the advancements of new theories of democracy and public administration, imprinted with Neoliberalism, New Public Management, and Good Governance paradigms.
PERSUASIVE COMMUNICATION OF THE #BUBARKANMUI MOVEMENT
Authors: Tayibnapis Radita Gora , Muqsith Munadhil Abdul , Sembada Windhiadi Yoga
Published: November 2023

The campaign narrative for the dissolution of the Indonesian Ulema Council (MUI) invited many comments from netizens on social media to develop into a digital social movement to urge the Indonesian Ulema Council (MUI) to be dissolved because one of its members was arrested by the police regarding the issue of terrorism. This news had become a trending topic on Twitter and threatened the existence of MUI as a forum for Islamic community organizations in Indonesia. To analyze these problems, researchers used the Network Society theory with a quantitative approach and the Social Network Analysis (SNA) method to analyze it. This study aims to analyze actors’ conversations in voicing new social movements through the #BubaranMUI hashtag. Through the spread of a communication network on the hashtag #BubarkanMUI, it was found to be an effort of a digital social movement that was echoed by political actors through a single Twitter account as well as building fake accounts as alter egos for intermediaries and network close relations to spread negative comments about MUI and spread communication networks as a public call through media atwitter and gain support from Twitter users to disband the MUI.
Surgical treatment of thyroid orbitopathy
Authors: Zabochnicki Mateusz , Szaraniec Wojciech , Pojda-Wilczek Dorota
Published: November 2023

Thyroid Orbitopathy is manifestation of Grave’s Disease that affects eyes and orbital area. It occurs in the active and inactive phase, during which different signs are presented. When Thyroid Orbitopathy reaches its advanced phase it should be operated, to avoid complications like proptosis or optic nerve neuropathy. Usually, the first choice is orbital fat decompression. However, it is often not enough and bony decompression is necessary. Surgery of the strabismus is also crucial for patient’s quality of life. Its aim is to restore visual field as wide as it is possible. Last step in surgical interventions is eyelid correction to prevent keratopathy and improve esthetic aspects.
Influence of laser correction of presbyopia using the Presbyond® Laser Blended Vision (LBV) method on the stereopsis
Authors: Wierzbowska Joanna , Pniakowska Zofia
Published: November 2023

Presbyond® Laser Blended Vision (LBV) method involves the non-linear aspheric ablation of the cornea with controlled induction of spherical aberrations in both eyes and the induction of micromonovision of -0.75 to -1.50 D in the non-dominant eye. The article presents the results of published studies analyzing the effect of laser correction of presbyopia using the Presbyond® LBV method on the stereopsis. The studies published so far indicate that the Presbyond® LBV treatment allows for maintaining functional postoperative stereoscopy, achieving patient satisfaction and independence from glasses.
Keratopatia taśmowata – chelatacja czy fotokeratektomia terapeutyczna
Authors: Alsoubie Ismael , Pyza Aneta , Kaczmarek Julia , Czarnacka Kinga , Prokop Dominika , Kuźlik Bartosz , Chmura Alicja , Pandey Ada , Gawlak Małgorzata , Żaczek Bartłomiej , Sajak-Hydzik Katarzyna , Pawlicka Ilona , Piskorz Agnieszka , Kozak Maciej , Roszkowska Anna Maria
Published: November 2023

Zwyrodnienia rogówki powodują zmianę jej kształtu i utratę przezierności. Podział zwyrodnień rogówki jest dokonywany na podstawie rodzaju substancji odkładających się w jej warstwach. Do substancji powodujących keratopatię można zaliczyć: żelazo, kolagen, hemosyderyny oraz sole wapnia, przez które powstaje keratopatia taśmowata. Ta ostatnia charakteryzuje się odkładaniem zmętnień w powierzchownych warstwach rogówki. W pracy omówiono leczenie keratopatii taśmowatej metodami chelatacji kwasem etylenodiaminotetraoctowym i fototerapeutycznej keratektomii laserem ekscymerowym.
Energy Consumption of Battery- Electric Buses: Review of Influential Parameters and Modelling Approaches
Authors: Jahic Amra , Eskander Mina , Avdevicius Edvard , Schulz Detlef
Published: November 2023

The electrification of public transportation fleets worldwide can pose a challenge to multiple stakeholders, such as the fleet operator or the operator of the local electrical grid. One of the important prerequisites for the successful integration of these fleets into the existing system is the knowledge of the energy consumption of the buses during their trips. The energy consumption varies depending on multiple factors such as the vehicle or route-related parameters, operational, and environmental parameters. This paper gives an overview of the latest research regarding these influential factors. Another essential prerequisite for the implementation of intelligent management systems for electric bus fleets is the forecasting of energy consumption. Researchers take different approaches to tackle this issue. A review of the latest research considering empirical approaches, physical models, regression, and machine learning is also provided in this paper. The findings of this paper provide a quick overview of different aspects of the energy consumption of electric buses and can therefore support other researchers or decision-makers in their work.
Child Perspectives and Children’s Perspectives – a Concern for Teachers in Preschool
Authors: Thulin Susanne , Jonsson Agneta
Published: November 2023

The aim of this article is to study and problematize the importance of the communicative approach of teachers related to child perspectives and children’s perspectives as well as the meaning for children's learning. The article is based on empirical material from two observational studies of preschool teachers at two Swedish preschools, children aged between 1 and 6. One theoretical basis of this article is that teachers not only ought to observe the understanding children are carriers of. Teachers also have to make use of the understanding in the continuing learning process to be able to support children's learning. Children need to be given the opportunity to be aware of and experience how their own understanding can be linked to new experiences. The results reveal qualitatively distinct communicative approaches with regard to how teachers verbally engage in and make use of what children are occupied with. The discussion relates this to child perspectives combined with children’s perspectives as a didactic basis.
STUDI KOMPARATIF ABORSI DI INDONESIA DAN KOREA SELATAN DALAM PERSPEKTIF FEMINIST LEGAL THEORY
Authors: Utamie R. Aj. Nindya Rizky
Published: November 2023

Abortion in Indonesia is still considered taboo and criminalized, while abortion in South Korea is the opposite. Countries that use the same legal system do not mean their regulations are also the same. Abortion raises different opinions from Pro-Life and Pro-Choice people. Analysis of feminist legal theory, especially radical feminism, is used to see the response of Indonesia and South Korea to abortion. This research aims to: 1) determine abortion regulations in Indonesia and South Korea; and 2) analysis of feminist legal theory regarding abortion in Indonesia and South Korea. This research is normative legal research or doctrinal research, using a statutory-regulatory approach, contextual approach, and comparative study. The data sources used are primary legal materials, namely Law Number 17 of 2023 concerning Health, the Criminal Code, and Law Number 1 of 2023 concerning the Criminal Code. Secondary legal materials are in the form of literature reviews related to legal materials that are appropriate to the research topic. The research shows that abortion in Indonesia is not fully legalized, in contrast to South Korea which has lifted the ban on abortion after the decision of the South Korean Constitutional Court. Based on the analysis of Feminist Legal Theory, Indonesia still has not accepted and accommodated all forms of demands from feminism, while South Korea considers abortion to be a woman's right and what is within a woman is her full right.
Effects of Vitamin E Supplemented Feed on Growth Performance of Fish: A Review
Authors:   Bangladesh Fisheries Research Institute, Rahman Md. Hashibur
Published: November 2023

Vitamin E (VE), an important lipid-soluble antioxidant, has great influence on growth and maintenance in animal.
Automatic Fish Detection and Species Classification Using Optimal Archimedes Shooty Term Deep Network
Authors:   Department Of Electronics And Communication Engineering, Sharma Bhubneshwar
Published: November 2023

The Optimal Archimedes Shooty-Term Deep Network algorithm employs image resizing and normalisation as a pre-processing step to enhance the quality of images.
West syndrome associated with lissencephaly - case report
Authors: Santos Gabriella , Meireles Pedro , Freitas Beatriz , Oliveira Janaina , Sousa Heloisa , Godoy Luciana , Cansino Julieta
Published: November 2023

Lissencephaly is a rare condition with a poor prognosis. It is characterized by a cerebral malformation due to deficient neuronal migration, which occurs between the 12th and 16th weeks of gestation. This deficient migration can generate changes in the cerebral parenchyma like agyria, pachigyria or heterotopic band. Due to the difficulty of clinical suspicion, it is essential to perform diagnostic imaging tests. It is a pathology with a poor prognosis that requires strict monitoring with a multidisciplinary team. It may be associated with West Syndrome (SW), which is characterized as an epileptic encephalopathy based on a triad: epileptic spasms, hypsarrhythmia in electroencephalography (EEG) and developmental arrest or psychomotor delay. The highest incidence is in males and between 3 and 12 months, being more common in the first two years of life. This syndrome is epileptogenic and can be etiologically classified as cryptogenic and symptomatic, the latter has a structural cause in the central nervous system, such as lissencephaly. The diagnosis of SW is made by the union between clinical characteristics, electroencephalographic findings (EEG) and imaging tests. Treatment, due to the difficult control of seizures, is usually done with combination of multiple antiepileptics. The case described here reports the clinical evolution of a pediatric patient with lissencephaly associated with West syndrome, highlighting the main milestones of his clinical evolution until diagnosis.
Lysosomal Acid Lipase (LAL) Deficiency: Enzyme Assay on Dried Blood Spot as Diagnostic Tool in a Patient Misdiagnosed as Niemann-Pick type C disease
Authors: Borges Marcella , Araujo Luissa , Lima Bruno , Vagnini Laura , Salles Alberto , Magalhães Guerino , Cristofolo João , Freitas João , Aranas Pedro , Fonseca Jacqueline , Timm Fernanda , Lourenço Charles
Published: November 2023

INTRODUCTION: Lysosomal acid lipase deficiency (LAL-D) is a lysosomal storage disorder involved in cholesterol ester metabolism. It is a poorly understood genetic cause of cirrhosis, dyslipidemia and premature atherosclerotic disease in children and adults. As the manifestations of LAL-D may resemble those observed in other more common diseases, delayed diagnosis is not uncommon. Wolman disease is an early-onset LAL-D phenotype that is usually fatal in the first year of life, but the most common form of the disease may occur at all ages. Recently, enzyme replacement therapy (ERT) for LAL-D has become available. CASE REPORT: A 12-year-old male patient was referred for hepatomegaly. Initially diagnosed as having Niemann-Pick type C disease (NPC), it did not present confirmatory mutations of this disease. Later, with enzymatic dosage of lysosomal acid lipase on filter paper, the diagnosis was redirected to LAL-D (with confirmation in enzymatic dosage in leukocytes and fibroblasts). DISCUSSION: Although LAL-D is considered a rare and uncommon cause of liver disease, recent studies point to a higher prevalence of this disease. Early diagnosis is essential, since specific treatment for this disease is already available. About half of patients with LAL-D die before age 21 in the absence of adequate treatment.
Left atrial appendix aneurysm: an accidental radiographic finding - case report
Authors: Malnarcic Camila , Palmeira Roberta , Terribele Jessica , Mascarenhas Myka , Coelho Pedro , Takahashi Mylena , Terribele Natan , Brandalize Elisa
Published: November 2023

Left atrial appendage aneurysm is an extremely rare condition. It usually oc-curs together with changes in the mitral valve and manifests itself with cardiac arrhythmias or thromboembolisms, most commonly between the second and fourth decade of life. It can be asymptomatic, and the diagnosis is made by ob-serving radiographic changes, such as the prominence of the left cardiac bor-der. Due to the complications that can occur, surgery for resection is recommended. The present study reports a case of an infant who was seen in con-sultation for a cough complaint two months ago. An investigation was initiated which diagnosed an aneurysm of the left atrial appendage. Therefore, it is shown that although it is more common between the second and fourth decades of life, the left atrial appendage aneurysm may also be present in children.
Renal abscess in pediatrics - Diagnostic and management difficulties: case report
Authors: Santos Alexandre , Andrade Maria , Hatanaka Eduardo
Published: November 2023

OBJECTIVE: To discuss the diagnostic difficulties of renal abscess in the pediatric age and warn pediatrics about the possible complications of urinary tract infections. CASE DESCRIPTION: A 16-year-old boy with autism spectre disorder and Duchenne muscular dystrophy presented at the emergency care unit with persistent fever despite the use of antibiotics to treat an urinary tract infection. Although there was leukocyturia, the urine culture was negative. Ultrassound of the urinary tract showed no significant findings. Computed tomography showed multiple renal abscesses in the right kidney. A puncture guided by ultrasound was performed. The culture of the liquid resulted in growth of ESBL Klebsiella pneumoniae. A 21 day course of intravenous antibiotic after the procedure resulted in complete resolution of signs and symptoms. COMMENTS: Renal abscess is a rare condition in the pediatric population. However, it must be considered in the differential diagnosis of prolonged fever and when there is a non-favorable evolution of urinary tract infection, mainly in recurrent episodes. The early diagnosis of this condition is essential for the adequate treatment and reduction of complications.
Pasang Surut Partisipasi Masyarakat Sipil dalam Pembentukan Kebijakan Publik di Aceh
Authors: Tjoetra Afrizal , Husna Cut Asmaul , Samwil Samwil , Fajri Raihal
Published: November 2023

Acehnese Civil Society Organizations have formed policy products, laws, and derivative products, such as the formation of Law Number 11 of 2006 concerning the Government of Aceh. The government started this law after signing an agreement between the Indonesian government and the Free Aceh Movement. However, the public participation has decreased in forming several Qanuns. The study aims to discover why public participation in policy formation in Aceh has decreased the supporting and inhibiting factors. The research was conducted using qualitative methods. Data was collected through literature study and interviews. The research results show the ebb and flow of civil society participation in the formation of public policy: (1) changes in behavior and government institutions, but followed by community apathy due to the lack of feedback on input in the discussion of laws and regulations; (2) increasing the capacity of public institutions or organizations, but followed by a decrease in the number of NGOs that focus on public policy advocacy; (3) ease of public access to information, but no impact on open government management and community welfare; and (4) social changes that support participation of civil society in the formation of laws and regulations. Meanwhile, the results also show the supporting factors, such as the availability of resources and guarantees for fulfilling public rights. The inhibiting factors for ongoing public participation in policy formation consist of the availability of resources, socio-cultural factors, and the lack of feedback or follow-up on public input
Gen Z Muslims in Conducting Mate-Selection in West Sumatra
Authors: Rahmaini Indah Sari , Hanandini Dwiyanti , Jendrius Jendrius , Ayu Nitia
Published: November 2023

This study aims to discover the subjective meanings of Gen Z Minangkabaus in West Sumatra in finding a mate and what popular cultural narratives produce these subjective meanings in the digital era. The method used in this research is to use a qualitative  approach with a case study type. The data collection techniques used are observation and in-depth interviews. The data will be analyzed using the Miles and Huberman analysis techniques with codification, data presentation, and conclusion. The research will be analyzed using late-modernity studies from Ulrich Beck as a representation of society in the digital era and religion as a sacred canopy from Peter L Berger. Studies show that Gen Z Minangkabaus in West Sumatra still have an attachment to the family in finding a partner, such as paying attention to the origin of the partner's family
Cultural Identity in the Shackles of Modernization: The Case of Mentawai Indigenous Peoples
Authors: Irwandi Ade , Taufik Rifki
Published: November 2023

This paper examines the shackles of cultural identity in the new flow of the times. Mentawai people as a community group have a local identity as a characteristic of an ethnic group. However, the attraction between local culture and the pace of modernization is getting stronger, where the influence of development hegemony and policies conflict with the cultural identity of the Mentawai people. So, it raises the chaos that is still ongoing until now. Through literature study and critical anthropology view, it shows that human has the potential to create creativity and self-adjustment. However, Mentawai people are limited and suppressed by social factors and conditions, and exploited by the 'authorities'. This means that the reality of being Mentawai people is not created by nature but by humans, namely humans who have the power to 'manipulate conditions' and patent meanings that suit their minds that are full of conflict, illusion, and distortion. Mentawai people are in a 'false consciousness' that modernization helps them see the world better and have consciously stuttered (cultural backwardness) from that objective condition. Culture is deliberately clashed with the pace of modernization in various elements of life. However, Mentawai people are not rigid and make adjustments from the politically charged situation that makes them marginalized, exploited, and subordinated. Cultural tactics (cultural meaning) to follow the pace of modernization are used. Modernization and globalization are considered 'interaction spaces' in which there is a contestation arena of various elements of human life.
STUDY OF THE CELLULASE ACTIVITY OF BACTERIAL STRAINS, UNDERLYING THE BIOLOGICAL PLANT PROTECTION PRODUCT “CODE OF BALANCE F1”, WHICH ARE POTENTIALLY CAPABLE OF CELLULOSE DECOMPOSITION
Authors:   Southern Federal University, Rostov-on-Don, Mekhantseva K.V. , Vasilchenko N.G. , Chistyakov V.A. ,   Almetyevsk State Oil Institute
Published: November 2023

When decomposing stable residues, strains that are capable of decomposing cellulose with the help of enzymes from the cellulase group are used. Cellulase activity of bacterial strains isolated from the rhizosphere zone of plants in the Krasnodar Territory was assumed: 8 strains of the genus Bacillus and 2 strains of the genus Paenbacillus. It turned out that 4 strains have high cellulase activity and can be neglected as possible decomposers of crop residues.
CYTOTOXIC AND PROOXIDANT EFFECTS OF AN ANTITUMOR FORMULATION OF MENADIONE BASED ON SOLID LIPID NANOPARTICLES
Authors:   Kazan Federal University, Nikolaeva V.A. , Zoughaib M. , Kamalov M.I. , Nakhmetova F.M. , Khokhlachev M.V. , Pashirova T.N. , Abdullin T.I. , Salakhieva D.V. ,   Arbuzov Institute of Organic and Physical Chemistry, Kazan
Published: November 2023

Solid lipid nanoparticles (SLN) containing encapsulated menadione and modified with L-arginyl-glycyl-L-aspartic acid (RGD) peptide were obtained. The colloidal characteristics of the formulations were studied and their influence on the viability and oxidative status of tumor cells was assessed.
DIRECT REPROGRAMMING OF PATIENT FIBROBLAST INTO NEURON-LIKE CELLS AS A PROMISING MODEL OF HUNTINGTON’S DISEASE
Authors:   Institute of Cytology RAS, Saint Petersburg, Parfenova P.S. , Mikhailova N.A. , Khotin M.G. , Kraskovskaya N.A. ,   Saint Petersburg State University,   Peter the Great Saint Petersburg Polytechnic University
Published: November 2023

The existing research of molecular mechanisms of Huntington’s disease (HD) progression, is expanded here by providing a modified method of direct reprogramming fibroblasts into neuron-like cells that keeps epigenetic changes important for late-onset HD progression. The HD cause seen as an expansion of CAG repeats within the Huntingtin gene. We anticipate our assay to be a starting point for preclinical trials on human cells rather than on mouse models.
THE USE OF WASTE FROM PHARMACEUTICAL PRODUCTION FOR THE CREATION OF BIOTECHNOLOGICAL PRODUCTS
Authors:   Kazan National Research Technological University, Petrenko O.A. , Samylova O.V. , Kuznetsova A.A. , Shcherbakova Yu.V. , Akhmadullina F.Y.
Published: November 2023

The state of the environment, excessive consumption of synthetic medicines, food additives and preservatives have a significant impact on the biological production of free radicals underlying a number of diseases and pathological conditions, such as atherosclerosis, coronary heart disease, oncological diseases and others. To correct these conditions and for preventive purposes, vegetable raw materials containing a large set of antioxidants are increasingly used: vitamins, flavonoids and tannins with a mild effect on the body and relatively low toxicity. However, even after the production of such organically pure preparations, a large amount of organic waste remains that can be reused. Only the collection of Eleutherococcus prickly is 400 tons per year. In this regard, the purpose of this work is to study the eleutherococcus meal formed during the production of a liquid extract based on it and to consider the possibility of its further use for obtaining biotechnological products.
USE OF TRIAZINYLAMIDOPHOSPHATE FOR INTRACELLULAR DELIVERY OF ASO AND COMPLEX DNA CONSTRUCTS
Authors:   SCAMT Institute, ITMO University, Saint Petersburg, Rybalko D.S. , Drozd V.D. , Patra C. , Eldeeb A.A. , Zharkov T.D. , Kuprushkin M.S. , Kolpashchikov D.M. ,   Almetyevsk State Oil Institute,   Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk,   Chemistry Department, University of Central Florida, Orlando, USA,   Burnett School of Biomedical Sciences, University of Central Florida, Orlando, USA,   National Center for Forensic Science, University of Central Florida, Orlando, USA
Published: November 2023

Most gene therapy agents are oligonucleotides that cannot cross the cell membrane on their own, thus various delivery systems and modifications are used. We tested the ability of triazinylamidophosphate, a lipophilic modification, to facilitate the passage of DNA strands into the cytoplasm. It ensures high efficiency of delivery and shows lower cytotoxicity in comparison with liposomes. Next, we designed a modified ASO carrier to achieve self-delivery.
APPLICATION OF APTAMER COMPLEXES WITH COMPLEMENTARY OLIGONUCLEOTIDES FOR THE DETECTION OF MYCOTOXINS IN HOMOGENEOUS SYSTEMS WITH FLUORESCENT DETECTION
Authors:   Bach Institute of Biochemistry RAS, Moscow, Samokhvalov A.V. , Serebrennikova K.V. , Zherdev A.V. , Dzantiev B.B.
Published: November 2023

The work is dedicated to the use of complexes of aptamers with complementary oligonucleotides. In the presence of target the oligonucleotide is displaced from the complex, which is accompanied by a change in the registered fluorescent properties of the label. The obtained regularities were applied for the detection of mycotoxins: ochratoxin A (detection limit was 0.09 ng/mL) and aflatoxin B1 (detection limit was 0.05 ng/mL).
NEW METHOD OF PROTEIN FOOD AND FEED PRODUCTS GENERATION ON THE BASIS OF TERRESTRIAL INVERTEBRATES RAISED IN FARM
Authors:   Tomsk State University, Skriptcova K.E. , Tshernyshev S.E. , Babkina I.B. , Baghirov R. T-o. , Modyaeva V.P. , Morozova M.D. , Subbotina E.Yu. , Shcherbakov M.V. , Simakova A.V.
Published: November 2023

A method for producing biomass of terrestrial invertebrates of Siberia is proposed. Two species of xylosaprophages beetle species (green rose chafer Cetonia aurata viridiventris and the European rhinoceros beetle Oryctes nasicornis) were contained on cellulose-rich feed substrates enriched with precursor material. Biochemical analysis of the larvae showed a high content of protein, fat, carbohydrates, vitamins and minerals with the highest content of magnesium and phosphorus.
ABILITY OF BACTERIA TO FORM BIOFILMS ON THE AQUEOUS PHASE AFTER HYDROTHERMAL LIQUEFACTION OF ACTIVATED SLUDGE
Authors:   Kazan National Research Technological University, Klementev S.V. , Kulikova Yu.V. , Sirotkin A.S. ,   Immanuel Kant Baltic Federal University, Kaliningrad
Published: November 2023

The ability of bacterial isolates (S2, S7, S9 and S11) to form biofilms for 72 h on the aqueous phase obtained as a result of hydrothermal liquefaction of activated sludge was studied. Experimental results showed that isolates S7 and S11 formed a more massive biofilm compared to other isolates by an average of 43 %. It was noted that during the co-cultivation of isolates S7 and S11, an increase in the massiveness of the biofilm by 96 % was observed compared with separate isolates.
DEVELOPMENT OF A KIT OF REAGENTS FOR THE DETECTION OF YELLOW FEVER VIRUS RNA BY ISOTHERMAL AMPLIFICATION WITH REVERSE TRANSCRIPTION
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Krivosheina E. I. , Kartashov M. Yu. , Chub E. V.
Published: November 2023

In this study we developed an experimental kit of reagents for the detection of yellow fever virus (YFV) RNA by loop isothermal amplification from reverse transcription. A plasmid construct containing the NS1 fragment of the YFV gene, which serves as a positive control in the reaction, was obtained. The analytical sensitivity and specificity of the analysis were determined using the developed set of reagents.
DEVELOPMENT OF RECOMBINANT BACTERIOPHAGES FOR THE PRODUCTION OF REINFORCED RNA
Authors:   Altai State University, Barnaul, Kulikov V. V. , Shcherbakov D. N. , Volkova N. V. ,   State Research Center of Virology and Biotechnology VECTOR, Koltsovo
Published: November 2023

We have developed a system for the construction of recombinant bacteriophages MS2, this technology makes it possible to obtain bacteriophages with specified RNA sequences, which allows us to produce stably stored, RNAse-resistant RNA for further use in highly sensitive analytical methods, as control samples, or in other tasks requiring protected RNA.