bluuebunny/crossref_metadata_2025 huggingface dataset:
THE IMPACT OF LARGE-SCALE SPORTS EVENTS ON THE SOCIO-ECONOMIC SITUATION IN THE SUBJECT OF THE RUSSIAN FEDERATION (ON THE EXAMPLE OF THE REPUBLIC OF TATARSTAN)
Authors: Farrakhova Rimma Rakipovna
Published: April 2023

Large-scale sports events attract a huge number of visitors, spectators, tourists, have a great impact on the economic situation of the host city, republic, region and the country as a whole. Thus, there is a need to build new sports facilities and create transport and social infrastructure. Public funds invested in their development pay off and are a cost-effective investment in maintaining the health and quality of life of the population. Large-scale sports events in the city of Kazan led to the development and popularization of sports among the population, improved the standard of living of the population and provided residents of the Republic of Tatarstan with modern sports infrastructure.
Peptidomic Analysis and Antimicrobial Activity of Serum Peptide from
Hevea brasiliensis Clone BPM24
Authors: Havanapan Phattara-orn , Ieamkheng Supaporn , Phungthanom Nuanwan , Bourchookarn Walairat , Bourchookarn Apichai , Krittanai Chartchai
Published: April 2023

Background::

Hevea brasiliensis is severely affected by the fungal disease caused by
Phytophthora spp. Significant loss of rubber yield is widespread and extensive use of chemical
fungicides has resulted in health and environmental problems.

Objective::

This work aims to extract and identify the latex serum peptides from a disease tolerant
clone of H. brasiliensis, and study the inhibitory efficacy against pathogenic bacteria and fungi.

Methods::

Serum peptides were extracted from H. brasiliensis BPM24 using mixed lysis solution.
Low molecular weight peptides were screened and fractionated by solid-phase extraction and then
identified by tandem mass spectrometry. Total and fractionated serum peptides were assayed for
bacterial and fungal inhibition using broth microdilution and poisoned food methods. An inhibitory
control study in the greenhouse was also performed using susceptible clones for pre and postinfection
with Phytophthora spp.

Results::

Forty-three serum peptide sequences were successfully identified. Thirty-four peptides
matched with the proteins associated with plant defense response signaling, host resistance, and
adverse environmental factors. The inhibitory study of total serum peptides demonstrated antibacterial
and anti-fungal properties. The greenhouse study exhibited disease inhibitory efficacy of
60% for the treatment of Phytophthora spp. in post-infected plants and 80% for pre-treated samples.

Conclusion::

Latex serum peptides from disease tolerant H. brasiliensis revealed several proteins and
peptides associated with plant defense and disease resistance. The peptides play a vital role for
defense against bacteria and fungi pathogens, including Phytophthora spp. Enhanced disease
protection can be obtained when the extracted peptides were applied to the susceptible plants before
exposure to the fungi. These findings provided an insight and may pave the way for the development
of biocontrol peptides from natural resources.
Isopeptide Bond Bundling Superhelix for Designing Antivirals against
Enveloped Viruses with Class I Fusion Proteins: A Review
Authors: Na Heiya , Liang Guodong , Lai Wenqing
Published: April 2023

Viral infection has become one of the worst human lethal diseases. In recent years,
major gains have been made in the research of peptide-based antiviral agents on account of the
mechanism of viral membrane fusion, among which the peptide Enfuvirtide has been listed for the
treatment of AIDS. This paper reviewed a new way to design peptide-based antiviral agents by
"bundling" superhelix with isopeptide bonds to construct the active advanced structure. It can
solve the problem that peptide precursor compounds derived from the natural sequence of viral
envelope protein tend to aggregate and precipitate under physiological conditions and low activity
and endow the peptide agents with the feature of thermal stability, protease stability and in vitro
metabolic stability. This approach is also providing a new way of thinking for the research and
development of broad-spectrum peptide-based antiviral agents.
Exploring the Effects of Chirality of 5-methyl-5-[4-(4-oxo-3H-quinazolin-2- yl)phenyl]imidazolidine-2,4-dione and its Derivatives on the Oncological Target Tankyrase 2. Atomistic Insights
Authors: Peters Xylia Q. , Poonan Preantha , Salifu Elliasu. Y. , Alahmdi Mohamed I. , Abo-Dya Nader E. , Soliman Mahmoud E. S.
Published: April 2023

Background:

Tankyrases (TNKS) are homomultimers existing in two forms, viz.
TNKS1 and TNKS2. TNKS2 plays a pivotal role in carcinogenesis by activating the Wnt//β-
catenin pathway. TNKS2 has been identified as a suitable target in oncology due to its crucial role
in mediating tumour progression. The discovery of 5-methyl-5-[4-(4-oxo-3H-quinazolin-2-yl)
phenyl]imidazolidine-2,4-dione, a hydantoin phenylquinazolinone derivative which exists as a
racemic mixture and in its pure enantiomer forms, has reportedly exhibited inhibitory potency
towards TNKS2. However, the molecular events surrounding its chirality towards TNKS2 remain
unresolved.

Methods:

Herein, we employed in silico methods such as molecular dynamics simulation coupled
with binding free energy estimations to explore the mechanistic activity of the racemic inhibitor
and its enantiomer forms on TNKS2 at a molecular level.

Results:

Favourable binding free energies were noted for all three ligands propelled by electrostatic
and van der Waals forces. The positive enantiomer demonstrated the highest total binding free
energy (-38.15 kcal/mol), exhibiting a more potent binding affinity to TNKS2. Amino acids
PHE1035, ALA1038, and HIS1048; PHE1035, HIS1048 and ILE1039; and TYR1060, SER1033
and ILE1059 were identified as key drivers of TNKS2 inhibition for all three inhibitors, characterized
by the contribution of highest residual energies and the formation of crucial high-affinity
interactions with the bound inhibitors. Further assessment of chirality by the inhibitors revealed a
stabilizing effect of the complex systems of all three inhibitors on the TNKS2 structure. Concerning
flexibility and mobility, the racemic inhibitor and negative enantiomer revealed a more rigid
structure when bound to TNKS2, which could potentiate biological activity interference. The positive
enantiomer, however, displayed much more elasticity and flexibility when bound to TNKS2.

Conclusion:

Overall, 5-methyl-5-[4-(4-oxo-3H-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione
and its derivatives showed their inhibitory prowess when bound to the TNKS2 target via in silico
assessment. Thus, results from this study offer insight into chirality and the possibility of adjustments
of the enantiomer ratio to promote greater inhibitory results. These results could also offer
insight into lead optimization to enhance inhibitory effects.
Plants of the Genus Mahonia as a Potential Traditional Chinese Medicine for the Prevention and Treatment of Alzheimer's Disease
Authors: Huang Shengfeng , Huang Yang , Yang Shuo , Shao Huikai , Chen Xiyu , Liu Qiwen
Published: April 2023

Alzheimer’s disease (AD), a prevalent multiple neurodegenerative disease, has gained attention, particularly in the aging population. However, presently available therapies merely focus on alleviating the symptoms of AD and fail to slow disease progression significantly. Traditional Chinese medicine (TCM) has been used to ameliorate symptoms or interfere with the pathogenesis of aging-associated diseases for many years based on disease-modifying in multiple pathological roles with multi-targets, multi-systems and multi-aspects. Mahonia species as a TCM present potential for anti-inflammatory activity, antioxidant activity, anti-acetylcholinesterase activity, and anti-amyloid-beta activity that was briefly discussed in this review. They are regarded as promising drug candidates for AD therapy. The findings in this review support the use of Mahonia species as an alternative therapy source for treating AD.
A Comprehensive Review on the Benzimidazole Scaffold as a Potential
Nucleus for Anticancer Activity
Authors: Pathak Shilpi , Sharma Richa
Published: April 2023

It is common knowledge that cancer is the world's biggest cause of mortality. This has led
to the ongoing introduction and validation of new cancer therapy outcomes. Benzimidazole derivatives
control DNA stability and cell cycle advancement. A heterocyclic nucleus is structurally more
favourable for a direct DNA connection and, thus, for the management of the DNA replication process.
This review seeks to explore the usefulness of such drugs in the future facets of cancer prognosis
and treatment in addition to discussing the role of benzimidazole in cancer therapy. Benzimidazole derivatives
have been reported as a pertinent therapeutic strategy to modify cancer progression and malignancy
in the data from 2013 to 2022. Here, we emphasize these features in several cancer types and
cell lines using in vitro and in vivo methods.
Isocyanide-based Multicomponent Reactions (IMCRs) in Water or
Aqueous Biphasic Systems
Authors: Divyavani Chitteti , Padmaja Pannala , Reddy Pedavenkatagari Narayana
Published: April 2023

Background:

Isocyanide is an intriguing one-carbon synthon that is frequently employed in a variety of carbon-carbon and carbon-heteroatom bond-forming reactions. Isocyanide-based multicomponent reactions (IMCRs) are effective synthetic tools in organic synthesis for the prepa-ration of complex heterocyclic molecules. The IMCRs in water have become an attractive research direction, enabling simultaneous growth of both IMCRs and green solvents towards ideal organic synthesis.

Objective:

The goal of this review is to provide a general overview of IMCRs in water or biphasic aqueous systems for accessing various organic molecules, as well as an examination of their bene-fits and mechanistic insights.

Conclusion:

High atom economies, mild reaction conditions, high yields, and catalyst-free process-es are crucial features of these IMCRs in water or biphasic aqueous systems.
Miscellaneous Naturally Derived Anticancer Agents
Authors: Punniyakotti Saranya , Saxena Pal Rashmi , Khera Kanav , Katiyar Deepti
Published: April 2023

Secondary metabolites of natural origin exhibit numerous pharmacological activities, like
anti-inflammatory and anti-oxidant effects. Lipid peroxidation has been observed to be prevented by
terminating free radical chains and chelating redox active metal ions. These properties of the secondary
products can also aid in preventing carcinoma. Many traditional and emerging plants are blessed
with plenty of unexplored phytometabolites, which contain the probability to carry huge antineoplastic
potential. Acetogenins are anticancer compounds that kill tumor cells through a variety and
series of developmental methods. They are very powerful apoptosis inducers that can regulate the exclusion
of chemotherapy medicines from cancer cells. Chalcone is a pharmacologically active molecule
that can be found in both natural and manufactured products. Marine species, which are also examples
of naturally derived drug sources, such as algae, sponges, tunicates, and bryozoans, have
emerged as important components of choice for the separation of novel anticancer drugs obtained
from marine sources. Bacteria of marine origin are the source of new drug discoveries and therapeutic
targets, which are being explored to unprecedented heights, and they have proven to be sources of various
medicinal agents, such as antibiotics, etc. Numerous secondary metabolites have been isolated
from marine fungi that were active biologically, structurally unique, and also therapeutically beneficial.
So far, almost 1000 secondary metabolites have been found, the majority of which are exclusive
to lichens. This mini-review discusses different aspects related to the natural derivatives obtained from
various sources, which play a pivotal role as anti-neoplastic agents.
Endocrine, Metabolic, and Immune Pathogenesis of Postmenopausal
Osteoporosis. Is there a Therapeutic Role in Natural Products?
Authors: Lisco Giuseppe , Triggiani Domenico , Giagulli Vito Angelo , De Pergola Giovanni , Guastamacchia Edoardo , Piazzolla Giuseppina , Jirillo Emilio , Triggiani Vincenzo
Published: April 2023

Background:

Bone health relies on the equilibrium between resorption and new bone generation. Postmenopausal osteoporosis depends on estrogen deficiency which favorite bone re-sorption and elevated risk of fractures. Moreover, osteoporosis is characterized by a high release of proinflammatory cytokines suggesting the role of the immune system in the pathogenesis of this complex disease (immunoporosis).

Aims:

To review the pathophysiology of osteoporosis from an endocrinological and immunological viewpoint and treatments with a specific focus on nutraceuticals.

Methods:

PubMed/MEDLINE, Scopus, Google Scholar, and institutional web site were searched. Original articles and reviews were screened and selected by September 2022.

Results:

The activation of the Gut Microbiota-Bone Axis contributes to bone health by releasing several metabolites, including short-chain fatty acids (SCFAs), that facilitate bone mineralization directly and indirectly by the induction of T regulatory cells, triggering anti-inflammatory path-ways.

Conclusion:

Treatments of postmenopausal osteoporosis are based on lifestyle changes, calcium and vitamin D supplementation, and anti-resorptive and anabolic agents, such as bisphosphonates, Denosumab, Teriparatide, Romosozumab. However, phytoestrogens, polyphenols, probiotics, and polyunsaturated fatty acids may improve bone health by several mechanisms, including anti-in-flammatory properties. Specific clinical trials are needed to assess the efficacy/effectiveness of the possible anti-osteoporotic activity of natural products as add on to background treatment.
Insight on Vernonia Plant for its Pharmacological Properties: A Review
Authors: Mishra Neha , Gupta Ena , Singh Priyanka , Soni Shashi , Noor Uroosa
Published: April 2023

Vernonia is a woody shrub of the family Asteraceae. Over 1500 species are distributed
in tropical and subtropical regions of Africa and Asia. There are more than 54 species known
to possess similar morphological features with the characteristic bitter taste. The pharmacological
properties of different parts like seeds, leaves, and roots are well documented in folk medicine.
They are rich in biologically active constituents such as alkaloids, phenolics, flavonoids,
terpenoids, steroid tannins, and carotenoids having broad therapeutic activities like antiinflammatory,
hypoglycemic, hyperlipidemia, antimicrobial, antitumor, antioxidative, antiproliferative,
antihypertensive, hepatoprotective, etc. The present study summarizes and discusses the
phytochemical profile, pharmacological properties, and toxicological effects of the Vernonia
plant.
The antibacterial activity of LL-37 peptide against multidrug-resistant Pseudomonas aeruginosa isolated from burn infections
Authors: AL-Sabagh Fadi S. H. , Ghaima Kais K. , Sh.AL-Dabbagh Alhan H.
Published: April 2023

Multidrug-resistant Pseudomonas aeruginosa has emerged as a significant problem worldwide, posing a severe hazard to burn-infected patients. Antimicrobial peptides produced from humans or animals and synthetic peptides have received interest as antibiotic options for treating resistant bacteria, particularly those obtained from burn patients. The current work evaluated the role of antimicrobial peptide LL-37 as an antibacterial agent against multidrug P. aeruginosa isolates from burn infections. The study samples were collected between November 2021 and the end of February 2022 and included 157 clinical specimens as burn swabs from patients with burn infections admitted to four Baghdad hospitals in Baghdad, Iraq. The results of selective media, biochemical tests, and the ITEK2 system identified 39 isolates (24.8%) as p. aeruginosa from all collected bacterial cultures. The findings of the antimicrobial susceptibility test by disc diffusion method for the isolates under investigation revealed that P. aeruginosa clinical isolates were moderately resistant to antibiotics tested. Most P. aeruginosa isolates were highly resistant to Tetracycline (89.7%), Azithromycin (71.7%), and Amikacin, Cefepime, and Gentamycin. Also, the highest sensitivity was recorded for Ciprofloxacin, Piperacillin/tazobactam, C ceftazidime and Levofloxacin. The results of minimum inhibitory concentrations (MICs) of LL-37 against (8) multidrug-resistant P. aeruginosa isolates revealed that the concentration range of LL-37 was (15.6-1000 µg/ml), indicating that LL-37 has a significant effect on P. aeruginosa growth at low concentrations. In conclusion, t using the antimicrobial peptides LL-37 in treating life-threaded infections could lead to developing a new generation of antimicrobials that can overcome bacterial resistance mechanisms.

Keywords: Antibacterial, Burns, LL-37, Pseudomonas aeruginosa
Video Counseling and a Safety Planning App to Support Pregnant Women Exposed to Intimate Partner Violence in Denmark and Spain During COVID-19 (Preprint)
Authors: Andreasen Karen , Linde Ditte S , Zapata-Calvente Antonella Ludmilla , Martín-de-las-Heras Stella , Megías Jesús López , Rasch Vibeke
Published: April 2023

BACKGROUND

Isolation was a consequence of the COVID-19 lockdowns, which led to increased incidence of intimate partner violence (IPV). During antenatal care, it is possible to screen pregnant women for IPV; this offers a unique opportunity for early intervention. During the pandemic, we designed and implemented a digital IPV intervention tailored to pregnant women in Denmark and Spain.

OBJECTIVE

This study aimed to identify pregnant women exposed to IPV through digital screening and offer video counseling as well as a safety planning app to those who screened positive.

METHODS

Pregnant women attending antenatal care were screened for IPV through a digital questionnaire. Women who screened positive were offered 6 video consultations with an IPV counselor and provided with access to a dedicated safety planning app. In-depth interviews inspired by the Model for Assessment of Telemedicine Applications were conducted with counselors and participants. The intervention was cocreated with women who have been exposed to IPV, nongovernmental organizations, and health care providers.

RESULTS

Despite the COVID-19 shutdowns, more than 15,000 pregnant women have been screened for IPV since January 2021. Qualitative interviews with women who completed the intervention as well as IPV counselors show broad acceptance of the video counseling, particularly the ability to participate from a safe environment and talk to a stranger about sensitive and stigmatizing issues. Preliminary findings show that both women and counselors find the video counseling highly supportive, empowering, and aligned with the needs for safety. The majority indicate improved well-being after the intervention, and neither counselors nor participants see video counseling as a barrier toward talking about sensitive topics such as IPV. The safety app was not perceived as effective.

CONCLUSIONS

The preliminary results show that video counseling conducted during the COVID-19 pandemic supports pregnant women exposed to IPV and is highly feasible and accepted in both Denmark and Spain.
Behind the Eyes of Adolescents from Broken Families
Authors: O. Digon Keisha Charisse
Published: April 2023

This qualitative phenomenological study explored the lived experiences of adolescents from broken families. This utilized an in – depth interview to gather responses from six (6) participants who were within the range of 13 – 19 years old, enrolled in Junior or Senior High School, have parents who were formerly married but separated in a period of 5 - 10 years (during the child’s early childhood to adolescence period based on Erik Erikson’s Psychosocial Stages of Development), and live in a province in the Philippines. The following themes, family as an emotional system, emotional setbacks, changes in their interpersonal relationship, acts of rebellion, went through the stages of grief, friends as support system, faithfulness in God, and hopeful and moving forward were derived from the study. Children from broken families displayed emotional distress that affected different aspects of their lives, but despite this challenging reality of being part of broken families, the participants of this study remained hopeful about their future. Indeed, the love and support of their loved ones served as a motivating force for them to be optimistic in life.
Concentraciones de nutrientes, digestibilidad in vitro y fermentación ruminal de residuos agroindustriales de Cannabis sativa L. como fuente potencial de forraje para rumiantes
Authors: Araiza-Rosales Elia Esther , Herrera-Torres Esperanza , Carrete-Carreón Francisco Óscar , Jiménez-Ocampo Rafael , Gómez-Sánchez Daniel , Pámanes-Carrasco Gerardo Antonio
Published: April 2023

This study aimed to determine the concentration of CP, EE, NSC, fibers, TPC, CT, CBD, THC, in vitro digestibility of dry matter and rumen fermentation parameters of agroindustrial residues of Cannabis sativa L. from two extractive processes of cannabinoids, as a potential source of forage in ruminants feeding. The flower of Cannabis sativa was exposed to cold-press extraction (CPC) and alcoholic extraction (AEC) process; vegetative residues obtained after extractions were compared to raw flower as a control (RFC) using a completely randomized design and Tukey’s test for means comparison. Extractive processes decreased EE, TPC and cannabinoids (CBD and THC). Otherwise, fibers, NSC and digestibility, increased after the extractive processes in CPC and AEC. Similarly, in vitro degradability increased after both extractive processes above 120 % as well as latency period. Additionally, protozoa increased with CPC but no changes were observed in AEC. Likewise, no changes were observed in cellulolytic bacteria in CPC and AEC. However, total bacteria were reduced after both extractions. Moreover, N-ammonia in ruminal fermentations decreased with CPC and AEC whereas total volatile fatty acids increased. In addition, gas production increased above 75 % in CPC and AEC; however, no changes were observed in latency period. Furthermore, methane and CO2 production increased above 80 and 60 %, respectively for CPC and AEC; these augmentations are positively associated with improvements in the ruminal fermentations. In conclusions, the agroindustrial residue of Cannabis sativa L. obtained after the analyzed extractive processes may arise as a potential forage source in ruminants feeding.
Relación entre rasgos de mediciones corporales, rasgos de mediciones de la ubre y producción de leche de cabras Saanen en el distrito de Capricorn de Sudáfrica
Authors: Makamu Thlarihani Cynthia , Madikadike Molabe Kagisho , Mokoena Kwena , Tyasi Thobela Louis
Published: April 2023

The association between body measurements and udder measurements can be used towards the improvement of milk yield. The objective of the study was to investigate the correlation between udder measurement traits and milk yield. The study was conducted at Sikline village in Mankweng, Capricorn district of Limpopo province, South Africa where a total number of 30 lactating Saanen goats were used. Pearson’s correlation technique was used for data analysis. The results showed a significant (P<0.05) correlation between distance between teats and milk yield (r= 0.45) and a highly negative significant (P˂0.01) correlation between teat diameter and milk yield (r= -0.57). Body weight and milk yield (r= 0.54) had a highly positive significant correlation (P˂0.01).  The finding of the current study implies that body weight and distance between teats can be used to improve the milk yield in Saanen goats. The finding of the study might be used to predict the milk yield of Saanen goats. However, further studies need to be conducted on relation of body and udder measurements and milk yield using higher sample size.
Kinship terms variation among speakers of Bahmaie dialect in Khuzestan Province of Iran
Authors: Tazik Khalil , Aliakbari Mohammad
Published: April 2023

Language indicates the social and cultural identity of the nations, and literature is of great value in reflecting ideas, beliefs and visions in language. Considering the fact that the local dialects that lack written literature are more subject to convergence and death, extensive research is required for further documentation and investigating the factors leading to their infrequency of use. Bahmaie, a variant of Luri dialect spoken in the southwest of Iran, is an example in which the stylistic variation of kinship terms represents dialect endangerment and necessitates in-depth analysis of the factors affecting this variation. The present study aims at examining the variation of Bahmaie kinship terms and their Persian equivalents across different contexts, with respect to age, gender, educational level, and third person presence. To this aim, a 32item questionnaire was designed and distributed among 275 Bahmaie speakers divided into four age groups: 15-19, 20-29, 30-39, and 40 - above. The findings of the study indicated that the 15-19 age group speakers favored the Persian terms while those aged 40 - above were more likely to use Bahmaie terms. They also showed the impact of other contextual characteristics on variation of kinship terms (interlocutors’ status, gender, educational level, and third person presence). Results further demonstrated that Bahmaie speakers have a tendency towards being persified, and this trend is more pronounced among young speakers. This tendency is attributed to the dominance of Persian as the only high-status language, language contact, and migration causing a generation gap. The implication of the research is that documenting Bahmaie dialect, encouraging educated speakers to use it and fostering intra-cultural communication, are the strategies that can be helpful in keeping this dialect alive.
Transgressive Russianness: Claiming authenticity in the Russian woman assemblage
Authors: Gritsenko Elena S. , Laletina Alexandra O.
Published: April 2023

The question of sociolinguistic authenticity has been widely researched with reference to authentic linguistic production and authentic language users. Globalization and intense language contacts have brought increased attention to the question of authenticity as it applies to what linguistic and cultural production is considered authentic and what facets of linguistic and cultural production are most salient to authenticity. The study examines the notion of authenticity in relation to the linguistic presentation of Russian womanhood by the Tajik-Russian singer Manizha in her song Russian woman . We aim to show how linguistic and cultural transgression underlying her performance prompted contestable interpretations and opened up the evaluative divide among the audience. Using Pennycook’s semiotics of transignification (Pennycook 2007), we analyze the performance at different levels (pretextual history, contextual relations, subtextual and intertextual meanings, and post-textual interpretations). We juxtapose the song, the singer’s post-performance interviews, and the viewers’ online comments in order to reveal the authenticating and deauthenticating discourses of gender and ethnicity. We have identified the opposing conceptions of Russian womanhood in the performance, both of which can be deemed authentic or inauthentic. We argue that authentication and deauthentication of this textual assemblage are driven by different ideologies and often depend on a single textual level or element. Moreover, authenticity may be recontextualized and renegotiated through discourse. The study highlights the co-existence of multiple and competing authenticies within a single multimodal performance and demonstrates how semiotics of transignification may be used to un-cover these competing ideological orientations.
Translingualism and intercultural narratives in Kiana Davenport’s “House of Many Gods”
Authors: Galaktionov Semyon Sergeevich , Proshina Zoya Grigor'evna
Published: April 2023

Language and culture contacts resulting from the migration of population, as well as current geopolitical and technological processes, enhance the increase of translingual works that reveal symbiotic phenomena of languages and cultures in contact. However, there are still many unsolved problems in defining the translingual discourse and linguistic devices for creating it. The article discusses intercultural narratives in a novel by Kiana Davenport, an American author of Hawaiian descent, whose literary creative translingual work is enhanced by intercultural phenomena related to the contacts of American English, Hawaiian, and Russian languages. The article aims to describe linguistic devices for creating translingualism and to characterize the processes that take place in assimilation and language alteration in contact situations. The research has revealed that translinguality characterizes not only texts that are written in a second language, as is a traditional point of view, but also writings of a bilingual with two native languages enhanced by a third one. Translinguality can be reached by various linguistic tools comprising lexical borrowings, including endonymic toponyms and culture-specific concepts, loan translations, allusions, as well as pidginization of speech and some others. The findings showed that pidginization of speech of different characters results in stylized dialogues with deviated articulation of English words, intentional grammatical deviations, set expressions from Hawaiian Pidgin and wordplay. The results of the paper expand the idea of translingualism and intercultural communication and can be used for further research into linguistic and cultural contacts.
Humidity - The Overlooked Variable in Thermal Biology of Mosquito-Borne Disease
Authors: Brown Joel , Pascual Mercedes , Wimberly Michael , Johnson Leah , Murdock Courtney
Published: April 2023

Vector-borne diseases cause significant financial and human loss, with
billions of dollars spent on control. Arthropod vectors experience a
complex suite of environmental factors that affect fitness, population
growth, and species interactions across multiple spatial and temporal
scales. Temperature and water availability are two of the most important
abiotic variables influencing their distributions and abundances. While
extensive research on temperature exists, the influence of humidity on
vector and pathogen parameters affecting disease dynamics are less
understood. Humidity is often underemphasized, and when considered, is
often treated as independent of temperature even though desiccation
likely contributes to declines in trait performance at warmer
temperatures. This Perspectives explores how humidity shapes the thermal
performance of mosquito-borne pathogen transmission. We summarize what
is known about its effects and propose a conceptual model for how
temperature and humidity interact to shape the range of temperatures
across which mosquitoes persist and achieve high transmission potential.
We discuss how failing to account for these interactions hinders efforts
to forecast transmission dynamics and respond to epidemics of
mosquito-borne infections. We outline future research areas that will
ground the effects of humidity on the thermal biology of pathogen
transmission in a theoretical and empirical framework to improve spatial
and temporal prediction of vector-borne pathogen transmission.
Intrusion detection using decision tree classifier with feature reduction technique
Authors: Shirazi Syed Atir Raza , Shamim Sania , Khan Abdul Hannan , Anwar Aqsa
Published: April 2023

The number of internet users and network services is increasing rapidly in the recent decade gradually. A Large volume of data is produced and transmitted over the network. Number of security threats to the network has also been increased. Although there are many machine learning approaches and methods are used in intrusion detection systems to detect the attacks, but generally they are not efficient for large datasets and real time detection. Machine learning classifiers using all features of datasets minimized the accuracy of detection for classifier. A reduced feature selection technique that selects the most relevant features to detect the attack with ML approach has been used to obtain higher accuracy. In this paper, we used recursive feature elimination technique and selected more relevant features with machine learning approaches for big data to meet the challenge of detecting the attack. We applied this technique and classifier to NSL KDD dataset. Results showed that selecting all features for detection can maximize the complexity in the context of large data and performance of classifier can be increased by feature selection best in terms of efficiency and accuracy.
Examining the Necessary Conditions for Successful Digital Transformation: A Case Study of Moroccan Companies
Authors: Bentaher Chaimaa
Published: April 2023

Internet spread and digital technology reshapes the landscape of whole industries and revolutionizes the traditional flows of goods. This technological development, which affects the world economy, is not without consequences for Moroccan firms, as they have to initiate and achieve a competitive digital transformation. This digitization is a matter of companies having a clear and coherent digital strategy, integrating new technology tools, questioning their business models and how value is built and delivered. This paper aims, particularly for companies at national level, to address and analysis the challenges and opportunities that are presented by digital transformation. In terms of methodology, with Moroccan companies we have adopted an exploratory qualitative-quantitative approach. The results of this study highlight the fact that human capital, funding and methodological support are the major challenges facing Moroccan companies.
Multiple solutions for eigenvalue problems involving the (p,q)-Laplacian
Authors:   ", Pucci Patrizia ,   Universita degli Studi di Perugia, Dipartimento di Matematica e Informatica, Via L. Vanvitelli, 1, 06123 Perugia, Italy e-mail: patrizia.pucci@unipg.it"
Published: April 2023

"This paper is devoted to a subject that Professor Csaba Varga suggested during his frequent visits to the University of Perugia and in my regular stays at the ""Babe s-Bolyai"" University. More speci cally, continuing the work started in [7] jointly with Professor Varga, here we establish the existence of two nontrivial (weak) solutions of some one parameter eigenvalue (p,q)-Laplacian problems under homogeneous Dirichlet boundary conditions in bounded domains of R^N."
Local existence and blow up of solutions to a logarithmic nonlinear wave equation with time-varying delay
Authors:   ", Choucha Abdelbaki ,   Department of Mathematics, Faculty of Exact Sciences, University of El Oued, B.P. 789, El Oued 39000, Algeria e-mail: abdelbaki.choucha@gmail.com", Ouchenane Djamel ,   "Laboratory of Pure and Applied Mathematics, Amar Teledji Laghouat University, Algeria e-mail: ouchenanedjamel@gmail.com or d.ouchenane@lagh-univ.dz"
Published: April 2023

"In this work, we are concerned with a problem of a logarithmic nonlinear wave equation with time-varying delay term. We established the local existence result and we proved a blow up result for the solution with negative initial energy under suitable conditions. This improves earlier results in the literature [11] for time-varying delay."
Nonlinear two conformable fractional differential equation with integral boundary condition
Authors:   ", Djiab Somia ,   Laboratory of Pure and Applied Mathematics, Mohamed Boudiaf University, Box 166, Ichbilia, 28000, M'sila, Algeria e-mail: somia.djiab@univ-msila.dz", Nouiri Brahim ,   "Laboratory of Pure and Applied Mathematics, Mohamed Boudiaf University, Box 166, Ichbilia, 28000, M'sila, Algeria e-mail: brahim.nouiri@univ-msila.dz"
Published: April 2023

"This paper deals with a boundary value problem for a nonlinear differential equation with two conformable fractional derivatives and integral boundary conditions. The results of existence, uniqueness and stability of positive solutions are proved by using the Banach contraction principle, Guo-Krasnoselskii's fixed point theorem and Hyers-Ulam type stability. Two concrete examples are given to illustrate the main results."
La investigacion sobre gobernanza global. Explorando patrones de crecimiento, diversidad e inclusión
Authors: Charles Roger  , Jordana Jacint , Holesch Adam , Schmitt Lewin
Published: April 2023

La gobernanza global se ha aceptado ampliamente como objeto de estudio y como forma de “ver” la política mundial. Sin embargo, todavía sabemos poco acerca de cómo ha evolucionado la publicación en lo que concierne a tal materia. Este artículo ofrece la primera exploración sistemática de estos patrones. Utiliza un conjunto de datos original de investigación sobre gobernanza global para responder tres preguntas de primer orden: ¿cómo ha variado la publicación a lo largo del tiempo?; ¿en qué temas se han centrado los estudiosos?; ¿y quiénes han estado publicando en este ámbito de estudios? Los autores descubrieron que la investigación ha aumentado y se ha vuelto cada vez más diversa, pero de manera selectiva. Algunos temas marginados ocupan un lugar más destacado que en el resto de las relaciones internacionales, pero también hay omisiones importantes. Por lo demás, si bien la investigación ya no procede tanto de la región estadounidense, y las mujeres han sido comparativamente más activas en relación con otras áreas, la diversidad geográfica sigue siendo por demás limitada. Los académicos con sede en el Sur Global se perfilan como los primeros artífices de menos del 14 por ciento de todas las publicaciones. Para concluir, el artículo promueve la reflexión sobre las implicaciones que todo ello tiene para el campo de estudio referido.
Trust evaluation in virtual software development teams using BERT-based language models
Authors: Zapata Sergio , Gallardo Facundo , Sevilla Gustavo , Torres Estela , Forradellas Raymundo
Published: April 2023

Nowadays, people from different geographical areas can be closely related thanks to advances in information and  communication technologies. This has a greater impact in software development organizations where their members form  virtual work teams. In these new co-located work scenarios, the construction of interpersonal trust is more complex and its  impact is very relevant in the performance of software development teams. This paper presents the results of the performanceevaluation of four pre-trained language models based on BERT applied to trust analysis tasks. For this work, a small dataset of 1453 comments obtained from software projects stored on Github was created. The evaluated language models achieved  moderately good values, in the order of 0.84 for the F1-score metric, which augurs that with further research they could be significantly improved.
Capabilities of Thomson parabola spectrometer in various laser-plasma- and laser-fusion-related experiments
Authors: Tchórz Przemysław , Szymański Maciej , Rosiński Marcin , Chodukowski Tomasz , Borodziuk Stefan
Published: April 2023

The Thomson parabola spectrometer (TPS) [1] is a well-known, universal diagnostic tool that is widely used in laser plasma experiments to measure the parameters of accelerated ions. In contrast to other popular ion diagnostics, such as semiconductor detectors or ion collectors, the TPS is not greatly affected by electromagnetic pulses generated during high-power laser interaction with matter and can be tuned to acquire data in various energy ranges of accelerated ions, depending on the goal of the experiment. Despite the many advantages of this diagnostic device, processing the collected data is a difficult task and requires a lot of caution during interpretation of gathered results. In this work, we introduce the basic principles of operation and data analysis based on the numerical tool created specifically for the TPS designed at the Institute of Plasma Physics and Laser Microfusion, present a range of data obtained during various recent experiments in which our TPS was used, and highlight the difficulties in data analysis depending on the purpose of the experiment and the experimental setup.
Hubungan Risiko Saham Dengan COVID-19
Authors: Anggara I Gde Wahyu Purna
Published: April 2023

COVID-19 has affected all aspects of life, including capital markets around the world, including Indonesia. This study aims to look at the impact of COVID-19 on changes in risk in stocks. Stock risks that are the object of research are overall risk (variance return) and market-based risk (stock beta). The research method used is a quantitative approach with a population of all company shares listed on the Indonesia Stock Exchange (IDX) with purposive sampling, where a sample of 67 companies was obtained. There is a significant difference between the total stock risk before the COVID-19 pandemic and during the COVID-19 pandemic. There is an increase in total stock risk during the COVID-19 pandemic. Furthermore, there is a significant difference between market risk before the COVID-19 pandemic and during the COVID-19 pandemic.

Keywords: Stock; COVID-19; Return; Stock Risk
Enriquecimiento de bacterias anammox a temperatura ambiente con inóculos de lodos activados
Authors:   Empresa Mixta “Aguas de La Habana”, La Habana, Cuba, Fernández Dorador Iván , Vega Aguilar Aylet ,   Universidad Tecnológica de La Habana “José Antonio Echeverría”, Facultad de Ingeniería Química, La Habana, Cuba
Published: April 2023

El descubrimiento del proceso de oxidación anaeróbica del amonio (anammox) abre nuevas alternativas para la eliminación de nitrógeno, más económicas que los tradicionales sistemas de nitrificación-desnitrificación. El enriquecimiento de estas bacterias se ve favorecido a temperaturas cálidas (superiores a 30 °C), similares a las que se logran en ambientes naturales cubanos. En este trabajo se evalúa el enriquecimiento de bacterias anammox a temperatura ambiente, con inóculos que provienen de diferentes sistemas de lodos activados para el tratamiento de aguas residuales municipales en Cuba. Los reactores son operados en batch y se alimentan con medio sintético con suficiente amonio, nitrito y carbonatos. La actividad anammox comienza a detectarse, bajo condiciones controladas, después de los 40 días. Los valores promedios obtenidos para las relaciones estequiométricas, N-NO2-/N-NH4+ y N-NO3-/N-NH4+, fueron de 1.16 y 0.22 respectivamente. El mayor valor de la actividad máxima específica que se logra en los enriquecimientos es de 0.160 gNT·gSSV-1·d-1, operando con velocidades de remoción de nitrógeno entre 150–350 mgNT·L-1·d-1 y alcanzando una eficiencia media de remoción de nitrito del 93.8 %. La actividad anammox en la fase estacionaria del crecimiento se afecta reversiblemente por la presencia de OD, lo cual es comprobado con ensayos en sistemas manométricos.
Formulasi Spray Gel Ekstrak Etanol Batang Etlingera rubroloba Menggunakan HPMC sebagai Gelling Agent
Authors: Indalifiany Astrid , Zubaydah Waode Sitti , Kasim Elvira Riskiyani
Published: April 2023

Herbal plants are one source of discovering secondary metabolites for active ingredients in medicine and one of them is Etlingera rubroloba from the Zingiberaceae group. The stems of these plants contain polyphenols as natural antioxidants. Application of natural antioxidants can be given topically through spray gel preparations. Spray preparations in gel form using HPMC can produce clear visuals, stable viscosity and do not irritate the skin. This study aims to obtain the optimal concentration of HPMC in the manufacture of E.rubroloba ethanol extract spray gel in terms of the resulting evaluation and physical stability. Formulation of spray gel based on the experimental method of optimizing gel base by adding E.rubroloba ethanol extract in various concentrations of HPMC 0.1% (F1); 0.2% (F2); 0.3% (F3) ; 0.4% (F4); and 0.5% (F5). The results showed that F1 with 0.1% HPMC had the best physical properties and stability of the preparation with a clear organoleptic, characteristic odor, and slightly viscous, producing a homogeneous spray gel, having a pH of 6, viscosity of 60 cps, spray weight of 0.13 gram, dry time 1.14 minutes, pattern and diameter of spraying spread well, and physically stable through centrifugation method stability test and cycling test.
The Impact of Covid-19 Pandemic on the Livestock Subsector
Authors: Mayulu Hamdi , Sawitri Endang , Tricahyadinata Irsan
Published: April 2023

The Covid-19 pandemic had an impact on human activities and all sectors globally. This study aims to review the impact of the pandemic on livestock products. Furthermore, data were collected from several literature, websites, national, and international news, relevant to current policies and conditions. The impact on the livestock sub-sector is not measured and includes a decrease in purchasing power and demand for livestock products such as meat, milk, and eggs, decreased profitability, hampered distribution of production inputs such as feed and medicine affect the increasing production costs, veterinary services limitation, hinder the livestock animal and product distribution, disruption on marketing and business downturn. Meanwhile, the positive impact is that farmers created an online-based digital innovation, known as e-commerce, involving product marketing, business, and product diversification. The Government also plays a vital role in demand and price stabilization, which ensures the supply chain sustainability of the products. Therefore, the livestock business can keep running sustainably, especially during the pandemic.
Autonomous Spacecraft Rendezvous Using Tube-Based Model Predictive Control: Design and Application
Authors: Specht Caroline , Bishnoi Abhiraj , Lampariello Roberto
Published: April 2023

As the concentration of large space debris increases, how rendezvous maneuvers involving these typically non-cooperative, freely tumbling bodies are planned and executed is evolving. The rendezvous must be carefully planned, employing up-to-date in situ data to identify the inertial and motion parameters of the target body, and executed in a manner that accounts for the remaining uncertainty in these parameters. This paper presents an extension of the Tumbling Rendezvous via Autonomous Characterization and Execution (TRACE) pipeline used in the ROAM/TumbleDock Astrobee experiment campaign, which sequences the target state estimation, motion planning, controller design, and maneuver execution tasks while additionally providing logical loop-back avenues to previous tasks, increasing the chances of a successful maneuver. The pipeline’s performance is analyzed in simulation, utilizing target state estimates generated in a previous activity on a dedicated on-ground test bed; online motion planning, based on nonlinear programming and warm-started using a trajectory library generated offline with a novel graphics-processing-unit-based method; and tube-based model predictive control to robustly track the planned trajectory. Tube-based model predictive control is an actively evolving subject, distributed over multiple publications and various research interests. The necessary theory and considerations for practical implementation of the method are consolidated; its use, features, and limitations in the proposed task are demonstrated.