bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS KINERJA PENGELOLAAN KEUANGAN DAERAH PROVINSI MALUKU
Authors: Marselina Dona , Soselia Kimberly Emma , Ningrum Cerafika Sri , Pangestu Novaldo Fardinan , Lero Agnes Febrina , Kristanti Putriana
Published: May 2023

ABSTRACT This study aims to analyze the regional financial performance of Maluku Province from 2019 to 2021. The research method uses descriptive statistical analysis. The analysis tool uses the measurement of independence ratio, effectiveness ratio, efficiency ratio, activity ratio, and growth ratio. This study analyzes the results of the data management obtained. The data used is historical data, namely secondary data in the form of published regional government financial reports. The findings show that the financial management performance of the Maluku Province in terms of the level of independence is very low with a pattern of instructive relationships with very effective and efficient management, an unbalanced activity ratio between operating expenditures and capital expenditures, and very low growth. Recommendations for the regional government of the Maluku Province to increase the budget and realization of their own regional income, so that the level of independence, effectiveness, efficiency, activity, and growth increases. Keywords:  Area, Finance, Maluku Province, Management, Performance.  ABSTRAK Penelitian ini bertujuan untuk menganalisis kinerja keuangan daerah Provinsi Maluku pada tahun 2019 sampai dengan tahun 2021. Metode penelitian menggunakan analisis statistik deskriptif. Alat analisis menggunakan pengukuran rasio kemandirian, rasio efektivitas, rasio efisiensi, rasio aktivitas, dan rasio pertumbuhan. Penelitian ini menganalisis hasil pengelolaan data yang diperoleh. Data yang digunakan merupakan data historis, yaitu data sekunder berupa laporan keuangan pemerintah daerah yang dipublikasikan. Temuan menunjukkan bahwa kinerja pengelolaan keuangan Provinsi Maluku dalam hal tingkat kemandirian rendah sekali dengan pola hubungan instruktif dengan pengelolaan yang sangat efektif, efisien, rasio aktivitas yang belum seimbang antara belanja operasi dengan belanja modal, dan pertumbuhan yang sangat rendah. Rekomndasi bagi pemerintah daerah Provinsi Maluku untuk meningkatkan anggaran dan realisasi pendapatan asli daerahnya, supaya tingkat kemandirian, efektifitas, efisiensi, aktivitas, dan pertumbuhan naik, membuat kebijakan dalam pengelolaan keuangan daerah yang dapat memberikan dampak positif kesejahteraan masyarakat. Kata kunci:  Daerah, Keuangan, Kinerja, Pengelolaan, Provinsi Maluku
Factors influencing employee performance and their impact on productivity: A study of commercial banks in Bangladesh
Authors: Atikur Rahaman Md. , Dilip Taru Rupali , Gupta Aman , Prajapat Vikash , Abdul Latif Mahmud Md.
Published: May 2023

Employees are the most valuable part of every organization in the world, and the success of the organization depends on how well its employees do their jobs. Nowadays, commercial banks in Bangladesh are growing overwhelmingly, so the competition is enhancing one bank to another. Employee performance at the firm level and workplace productivity has not been empirically studied in the context of Bangladesh. The purpose of this study is to find out the variables that affect how well employees at banking institutions in Bangladesh do their jobs. People who worked in private banks in Bangladesh were the focus of this study and the final sample size was 250. The sample size was suitable for quantitative regression analysis. The questionnaire was sent to the e-mail ids of employees, and the questionnaires were adopted from the previous studies. To test the model and hypothesis, SPSS is used to analyze collected data in this study. The regression analysis was duly run with using the SPSS 26.0 version. The study shows that competence, compensation, leadership, and motivation have a big and good effect on how well employees do their jobs in regard to private commercial banks in Bangladesh. So, bank authorities should identify the factors influencing the improvement of the performance of bank employees, and they need to focus on employee productivity-enhancing activities.
Non-invasive assessment of ulcerative colitis activity when choosing a treatment regimen
Authors: Pimanov S. I. , Dikareva E. A.
Published: May 2023

In recent decades, there has been a steady increase in the incidence of ulcerative colitis worldwide. The purpose of the work was to analyze the literature data on modern features of the treatment of ulcerative colitis, as well as to present our own results and cases from practice. Mesalazine remains the mainstay of remission and often its induction in patients with ulcerative colitis. Currently, the nature of the treatment of ulcerative colitis is determined by the target level of remission. The fact of the onset of endoscopic remission is known to occur much later than subjective clinical improvement. In recent years, this provision has been supplemented by evidence of a delay in histological, laboratory (fecal calprotectin) and transmural remission from endoscopic. There is increasing evidence that the duration and quality of remission depends on the depth of remission. When using ultrasound, it is not difficult to urgently assess the activity and prevalence of inflammation by the parameters of the intestinal wall. Together with the level of fecal calprotectin, this information may be key to the choice of induction, escalation, maintenance or de-escalation treatment options. Of course, endoscopic examination with colon biopsy remains a necessary planned component of the management of a patient with ulcerative colitis. There are 3 cases from practice in which the achievement of transmural remission was carried out during the treatment with mesalazine. The possibility of monitoring the activity of the inflammatory process and its prevalence in the colon with the help of ultrasound examination of the intestinal wall has been clearly demonstrated. According to the results of our study, it was found that with a high activity of the disease according to the scale of Doppler mapping of the colon wall (Limberg 4), an erosive-ulcerative process was recorded in all patients according to the results of endoscopic examination (Mayo 3). Detection of the normal intestinal wall on the echogram in all cases was accompanied by the absence of endoscopic activity (Mayo 0) or its minimal manifestations (Mayo 1).
Ursodeoxycholic acid: unique properties and clinical applications
Authors: Maevskay M. V.
Published: May 2023

Ursodeoxycholic acid (UDCA) is a natural hydrophilic bile acid, which is present in humans as a small fraction of the total amount of bile acids (5%). Its unique properties underlie its use in a number of liver diseases as a first-line therapy. The ability of UDCA to reduce the secretion of cholesterol into bile, form mixed micelles (liquid crystals) with cholesterol molecules and interact with multifunctional nuclear receptors, are actively used in the treatment and prevention of cholelithiasis. UDCA has the ability to stimulate hepatobiliary secretion, promotes the secretion of bicarbonate by cholangiocytes, which is relevant for patients with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). UDCA activates transporter proteins such as bile acid export pump (BSEP), multiresistance protein 2 (MRP2) – conjugates transporter, type 2 anion exchanger (AE2), and promotes their movement to the canalicular membrane of cells. UDCA acts as a pleiotropic agent that plays a unique role in modulating the classical mitochondrial pathway of apoptosis in various cell types. Double molecular bonds of UDCA serve as a trap for free radicals, which suppresses the processes of lipid peroxidation. The ability of UDCA to penetrate into mitochondrial membranes leads to suppression of the activity of mitochondrial oxidase enzymes responsible for the production of superoxide anion. UDCA activates autophagy and promotes the elimination of toxic fatty acids from hepatocytes, reducing liver steatosis, UDCA has anti-inflammatory, antifibrotic, immunomodulatory and anticarcinogenic effects. UDCA is included in international and Russian clinical guidelines for the treatment of patients with various liver diseases (PBC, PSC, intrahepatic cholestasis of pregnancy, drug-induced cholestasis, alcoholic liver disease with cholestatic component), cholelithiasis, cystic fibrosis. In the pharmacotherapy of non-alcoholic fatty liver disease, UDCA is the only drug that has a bi-directional effect on the liver and cardiovascular system.
Gastritis and dyspepsia: differentiation as the cornerstone of pharmacotherapy
Authors: Bordin D. S. , Livzan M. А. , Kucheryavyy Y. А. , Mozgovoi S. I.
Published: May 2023

Chronic gastritis is a complex, polyetiological pathology with no clear clinical presentation. The most significant etiological factor of gastritis to date is H. pylori infection. A common clinical manifestation is the dyspepsia syndrome, which is caused by impaired motility. Symptoms can significantly affect a patient’s quality of life, necessitating rapid and effective pharmacotherapy. This paper discusses the algorithm of the physician actions in the case of a patient with uninvestigated dyspepsia. PPI has significant negative impact on the accuracy of H. pylori diagnostic test results. In this regard, it is proposed to use empirical therapy with prokinetics before diagnostic test would be performed. Among the prokinetics available on the Russian market, itopride hydrochloride stands out due to its high safety profile and proven efficacy. Current evidence supports the use of the prokinetic Ganaton® (itopride hydrochloride) as empirical therapy for dyspepsia of undetermined etiology, including patients with a preliminary diagnosis of gastritis. Due to its dual mechanism of action, itopride hydrochloride alleviates dyspeptic symptoms by improving gastric evacuation and can be used for an extended period. Several studies have shown the superiority of itopride in treating functional dyspepsia compared to other prokinetics, including metoclopramide and domperidone. Thus, prescribing the prokinetic Ganaton® (itopride hydrochloride) as empirical therapy for dyspepsia of undetermined etiology, including patients with a preliminary diagnosis of gastritis, is a pathogenetically justified approach aimed at improving the patient’s condition in the short term before establishing a final clinical diagnosis.
Theoretical aspects of prescribing ustekinumab as first-line therapy for Crohn’s disease
Authors: Shapina M. V.
Published: May 2023

The treatment of Crohn’s disease is a complex process in which it is necessary to take into account not only the current condition of the patient and the risks of disease progression, but also the sequence of therapy. To date, only biological drugs can change the course of the disease, but their number is limited and they should be prescribed taking into account the choice of the optimal sequence for each patient, since the effectiveness of any biological drug is affected by previous treatment. Unfortunately, there are no common recommendations on the sequence of choosing biological drugs, and the issue of choosing a first-line drug is relevant. Ustekinumab is a biologic agent targeting interleukin-12 and 23 that has been shown to be effective and safe in the treatment of both patients after TNF-alpha inhibitors and bionaive patients. It has also been shown to be effective in the treatment of strictures and perianal manifestations of Crohn’s disease. Ustekinumab is also effective against articular extraintestinal manifestations such as arthralgia and psoriatic arthritis. A high response rate to ustekinumab was also found in patients with dermatological manifestations – psoriasis, pyoderma gangrenosum, and erythema nodosum. In addition, a good safety profile allows its use in elderly patients. Of particular interest is the direct comparison of biologics. To date, there is only one randomized head-to-head trial of ustekinumab and adalimumab showing comparable efficacy results. And there is also data from a post hoc analysis of randomized trials, where its effectiveness is comparable to infliximab. Thus, ustekinumab can be prescribed for the treatment of Crohn’s disease, including in the first line of therapy.
Subpopulation composition of blood T-killers in patients with hepatitis C with genotype 1 or 3
Authors: Cherepnin M. A. , Tsukanov V. V. , Savchenko A. A. , Vasyutin A. V. , Borisov A. G. , Belenyuk V. D. , Tonkikh J. L.
Published: May 2023

Introduction. Despite great attention to the pathogenesis of chronic viral hepatitis C (CVHC), many aspects of the immune response in this pathology remain unclear. Aim. To study the subpopulation composition of blood cytotoxic T cells by flow cytometry, depending on the severity of clinical and morphological manifestations of CVHC with genotype 1 or 3. Materials and methods. Clinical, laboratory examinations, determination of liver fibrosis by elastometry using the METAVIR scale and study of the subpopulation composition of cytotoxic T cells in the blood were carried out in 144 patients with CVHC, including 74 patients with genotype 1 and 70 individuals with genotype 3, and in 20 people of the control group. The study of the subpopulation composition of cytotoxic T cells in the blood was carried out on a flow cytometer Navios (Beckman Coulter, USA) with the determination of CD3, CD8, CD45R0 and CD62L markers. Results. Changes in the subpopulation composition of blood cytotoxic T cells were more associated with the severity of liver fibrosis in patients with 1 and 3 genotypes of CVHC, than with inflammatory activity and viral load. In patients with CVHC genotype 3, a marked decrease in the content of TEMRA T-cytotoxic cells (CD3+ CD8+ CD45R0–CD62L–) and effector memory T-cytotoxic cells (CD3+ CD8+ CD45R0+ CD62L–) was registered in patients with METAVIR liver fibrosis stage F3-F4 in comparison with persons with METAVIR liver fibrosis stage F0-F1 (Kruskal-Wallis test, respectively, p = 0.02 and p = 0.04 In persons with CVHC genotype 1, similar associations were expressed to a lesser extent.Conclusion. We obtained an association of deterioration in the indices of the blood cytotoxic T cells subpopulation in patients with CVHC with an increase in the severity of liver fibrosis, which had some differences in patients with genotypes 1 and 3.
Generic drugs of direct antiviral action for the treatment of hepatitis C: features of bioequivalence studies
Authors: Eremenko N. N. , Uvarova N. E. , Serebrova S. Yu. , Demchenkova E. Yu. , Shikh E. V.
Published: May 2023

Introduction. In the last decade, approaches to the treatment of chronic viral hepatitis C (HCV) have undergone significant changes. The new WHO strategy aims to eliminate HCV by 2030 by reducing the number of new infections and deaths by simplifying hepatitis C therapy. The development of drugs for the treatment of patients with chronic HCV has a number of features, which requires compliance with special recommendations for conducting clinical bioequivalence studies.Aim. The study was to analyze the guidelines and protocols of bioequivalence studies of drugs for HCV therapy. Materials and methods. An information and analytical method was used to evaluate recommendations for conducting bioequivalence studies of HCV drugs according to the US Food and Drug Administration, the European Medicines Agency, and WHO. Separately, an analysis of permitted clinical trials was carried out according to the data of the GRLS of the Ministry of Health of the Russian Federation. Results and discussions. According to the results of the study, it was noted that for the WHO guidelines on the bioequivalence of drugs for HCV therapy, it is common to develop common principles for planning and conducting research. Special attention is paid to the preferred design of the study. It is also necessary to analyze data on the variability of the pharmacokinetic parameters of the substance under study, which are used to calculate the required number of volunteers to be included in the study. Conclusions. Direct antiviral drugs under development for HCV therapy, for which clinical bioequivalence studies are currently being conducted in the Russian Federation, cover a large list of INN. The entry of new reproduced drugs into the pharmaceutical market will improve patients’ access to effective treatment of hepatitis C. In order to conduct a high-quality bioequivalence study, it is necessary to thoroughly familiarize yourself with nosology manuals, critical assessment and analysis of information, which will allow you to choose the appropriate design of the study and correctly plan its conduct.
Does knowledge and brand image affect the intention to save in Islamic banks?
Authors: Adiyati Alfi Khaerah , Arwiyanah Arwiyanah , Baharuddin Jukri , Affandy Fachrudin Fiqry , Firdaus Muhammad Anang
Published: May 2023

Purpose- This study aims to determine the effect of knowledge and brand image variables related to the interest of IAIN Fattahul Muluk Papua students in saving at Islamic banks. Method- This research is a quantitative research using multiple regression analysis method with two X variables and one Y variable and the data in this study were obtained from 62 students who were collected through questionnaires distributed. Result- The results of the study show that knowledge and brand image have a significant effect on students' interest in saving at Islamic banks. Implication- This research has implications for increasing students' knowledge of Islamic banks by providing courses that are directly integrated into the application of products and services in Islamic banks. Furthermore, to increase the brand image of Islamic banks among students, they can continue to collaborate between the two institutions. Originality- This study looks directly at the influence of knowledge and brand image by students which will be able to influence them to save at Islamic banks. Considering that there are not too many Islamic banks in the province of Papua and they are still very new.
Risk analysis of meteorological, agricultural, and hydrological drought events and study of drought propagation features: a case study in the upper Tapti River sub-basin, Central India
Authors: Kanthavel P. , Saxena C. K. , Singh R. K.
Published: May 2023

As a natural hazard, drought is a complex multivariate phenomenon that requires more comprehensive analysis. In this study, we studied meteorological, agricultural, and hydrological drought events with precipitation, soil moisture, and stream flow data for the study area. The risk analysis for drought duration and severity of three kinds of drought events were analyzed with univariate and three kinds of bivariate return periods based on the copula. Furthermore, the propagation of three kinds of drought was studied. From the investigation, it is observed that agricultural drought events are longer and more severe, besides the risk associated with agricultural drought is high compared to other kinds of drought. Moreover, the average time taken for meteorological drought to propagate into agricultural drought is 4.3 months and for the hydrological drought is 3.8 months for the river basin. The comprehensive study of three kinds of drought is helpful to adopt suitable drought management plans in the region.
Network Pharmacology and Intestinal Microbiota Analysis Revealing the
Mechanism of Punicalagin Improving Bacterial Enteritis
Authors: Huang Shuyun , Wang Ying , Zhu Qingsong , Guo Hongmin , Hong Zongyuan , Zhong Shuzhi
Published: May 2023

Background:

The Chinese medicine punicalagin (Pun), the most important active ingredient
in pomegranate peel, has significant bacteriostatic and anti-inflammatory properties. The
potential mechanisms of Pun for bacterial enteritis, however, are unknown.

Objective:

The goal of our research is to investigate the mechanism of Pun in the treatment of bacterial
enteritis using computer-aided drug technology, as well as to investigate the intervention
effect of Pun on mice with bacterial enteritis using intestinal flora sequencing.

Methods:

The targets of Pun and Bacterial enteritis were obtained by using the specific database,
and cross-targets were screened among these targets, followed by PPI and enrichment analysis of
the targets. Furthermore, the degree of binding between Pun and key targets was predicted through
molecular docking. After successfully establishing the bacterial enteritis model in vivo, mice were
randomly assigned to groups. They were treated for 7 days, the symptoms were observed daily,
and the daily DAI and body weight change rate were calculated. Following administration, the
intestinal tissue was removed, and the contents were separated. The tight junction protein expression
was detected in the small intestine by the immunohistochemical method; ELISA and Western
Blot (WB) were performed to detect the expressions of tumor necrosis factor-α (TNF-α) and interleukin-
6 (IL-6) in the serum and intestinal wall of mice. The 16S rRNA sequence was used to determine
the composition and diversity of the intestinal flora of mice.

Results:

In total, 130 intersection targets of Pun and disease were screened by network pharmacology.
The enrichment analysis showed cross genes were closely related and enriched in the cancer
regulation and the TNF signal pathway. The active components of Pun could specifically bind
to the core targets TNF, IL-6, etc., determined from molecular docking results. In vivo experiment
results showed that the symptoms in the PUN group mice were alleviated, and the expression levels
of TNF-α and IL-6 were significantly reduced. A Pun can cause substantial changes in the intestinal
flora of mice in terms of structure and function.

Conclusion:

Pun plays a multi-target role in alleviating bacterial enteritis by regulating intestinal flora.
Recent Advancements and Applications of Size Exclusion Chromatography
in Modern Analysis
Authors: Bhatia Rohit , Kumari Yogindra , Chopra Arshdeep
Published: May 2023

In recent years, size exclusion chromatography (SEC) has gained valuable and impactable
recognition among various chromatographic techniques. Also addressed as other names, viz. gel permeation
chromatography, steric-exclusion chromatography, etc., SEC is typically taken into consideration for
the fractionation and molecular weight determination of biomolecules and large macromolecules (proteins
and polymers) using porous particles. A homogenous mixture of molecules dispersed in the mobile phase
is introduced to the chromatographic column, which provides a solid support in the form of microscopic
beads (the stationary phase). The beads act as “sieves” and purify small molecules, which become temporarily
trapped inside the pores. Some of the advantages that SEC offers over other chromatographic techniques
are short analysis time, no sample loss, good sensitivity, and requirement for less amount of mobile
phase. In the proposed manuscript, we have deliberated various proteomic applications of size exclusion
chromatography, which include the isolation of extracellular vesicles in cancer, isolation of human
synovial fluid, separation of monoclonal antibodies, as well as several tandem techniques, such as deep
glycoproteomic analysis using SEC-LC-MS/MS, analysis of mammalian polysomes in cells and tissues
using tandem MS-SEC, SEC-SWATH-MS profiling of the proteome with a focus on complexity, etc.
Secrecy Performance Review for IoT-based Cognitive Farming System
Authors: Chopra Khyati , Alam M. Afshar
Published: May 2023

Smart farm management has complex challenges; therefore, there is a need to improve
the overall adaptability, profitability, and environmental soundness of the farming systems. Agricultural
production can be enhanced with the help of IoT-based cognitive tools. The rapid increase
in IoT-based smart systems has raised critical concerns about efficiently utilizing the wireless spectrum.
To drastically bring the improvement in the utilization of the wireless spectrum, cognitive radio
(CR) has emerged as an effective solution. The inherent openness and broadcast nature of the
wireless medium have given rise to many security issues in cooperative networks. Informationtheoretic
security or physical layer security (PLS) is evolved as an efficacious wireless prototype
for reliable transmissions to avert the eavesdropper from expropriating transmittal data on the wireless
connections. Security is the key factor in these networks as they are exposed and active in behavior,
thus, are susceptible to fraudulent activities. We investigated the performance of the CR
system in terms of secrecy and also examined the system in terms of diversity receipt and selection
of relay. The secrecy outcome of channel state information at the sender was also studied. The detrimental
effects of fading in cooperative networks were also extensively discussed. Cooperative diversity
was examined by deploying MRC and SC strategies at receptors. It has been deduced that CSI
knowledge at the sender also has an eloquent concussion on the secrecy of the cognitive system.
Preparation and Evaluation of Medicated Formulation for Dry Eye
Authors: Singh Nishita , Maurta Rahul , Mishra Sudhanshu , Jain Deepti
Published: May 2023

Introduction:

The current research involved the study of chondroitin sulfate polymer to prevent
moisture loss, which was formulated to treat dry eye.

Methods:

The ophthalmic formulation was prepared with 5% liquid paraffin wax, 10% carbowax, and 1%
glycerine. Furthermore, its usefulness in ophthalmology was analyzed by measuring parameters like pH,
isotonicity, turbidity, viscosity, % moisture loss, vapor pressure, and in-vitro and in-vivo corneal damage.

Results:

We successfully adjusted the pH and osmolality of the F2 formulation to the desired physiological
levels, providing the opportunity to reduce the harmful reaction as well as inflammation and dehydration.
In addition, viscosity plays an important role in ophthalmic preparation. Consequently, the stability
studies of optimized formulation indicated no remarkable changes in physical properties, including pH,
viscosity, phase separation, and turbidity. Furthermore, a vapor pressure manometer studied the percentage
of moisture loss. Interestingly, the HET-CAM test correlated properly with the findings of the Draize
eye inflammation test. Moreover, the in-vivo irritation test of the optimized system showed that it was
tolerable, with no signs of irritation in the rabbit eye compared to the marketed formulation. In addition,
the F2 formulation demonstrated better results than the marketed corneal preparation. Thereby, from the
results, it can be concluded that the simple manometer apparatus can be the best method for evaluating
moisture loss prevention for dry eyes. No study or investigation has been reported before for ophthalmic
preparation.

Conclusion:

Altogether, chondroitin sulfate with carbowax 1000 and liquid paraffin-based ophthalmic
preparation can be considered a promising approach for preventing dryness of the eye.
Efficient administrative management strategy for activities in international higher education institutions
Authors: Thang Pham Dinh , Tuyen Tran Quang
Published: May 2023

This research article examines the significance of efficient administrative management in international higher education institutions and addresses the specific challenges faced in managing activities effectively. The objective of this study is to propose an administrative management strategy tailored to the context of Vietnam's international higher education institutions. Drawing upon existing literature, theoretical frameworks related to organizational management, leadership, governance, and strategic planning are explored to inform the development of the strategy. The unique characteristics and challenges of the Vietnamese higher education system, particularly in relation to internationalization efforts, are described, highlighting the importance of aligning administrative management strategies with local context while incorporating international best practices. Essential components of an efficient administrative management strategy, including organizational structure, decision-making processes, resource allocation, staff development and training, technology integration, and quality assurance, are identified and discussed in detail. Successful case studies and best practices from international higher education institutions are analyzed, providing valuable lessons and insights that are relevant and applicable to the Vietnamese context. Specific recommendations and guidelines are provided for Vietnamese higher education institutions seeking to enhance their administrative management practices, considering cultural, institutional, and regulatory factors.
Vata - The Niyanta and Praneta of Manas
Authors: Madlur Amruta , J. R. Joshi
Published: May 2023

Ayurveda is the most ancient medical science of the world. It is practiced to attain Chaturvidha Purusharthas namely Dharma, Artha, Kama and Moksha. Shareera becomes main Sadhana for attaining these Purusharthas. Ayurveda gives importance to both Shareerika and Manasika Swasthya equally. Vata, Pitta, Kapha popularly known as Tridoshas are chief functional components of the body. Equilibrium of these Doshas is very essential for maintenance of all activities in the body. When these Doshas are balanced, all activities related to body, mind and senses occur smoothly. With this, one can enjoy a status of perfect health and immunity. On the other hand these Doshas are imbalanced, they cause various diseases. Shareera and Manas are inter-related. Always Shareera follows Manas and Manas follows Shareera. Vata Dosha is known to be related with Rajo Guna and thereby we can see effect of fluctuation of theses Doshas in Shareera, results in different conditions. So, in case of vitiation of Vata, there is also vitiation of Rajo Guna which ultimately vitiates Manas and its attributes. So, it can be said that, Vata acts as the root cause of different Manasa Roga.
Role of Sthanik Chikitsa in Stree Roga
Authors: Choudhary Malika , Rajpurohit Divya
Published: May 2023

Healthy status of women is very much needed for society. In today's fast and competitive world, there is change in the lifestyle of women which leads to their physical and mental stress, women mostly gets affected by this environment and are prone to gynaecological problems. Womens always face very common gynaecological problems like white discharge, itching at vulva, foul smelling vaginal discharge, burning micturition etc. In such problems Sthanika Chikitsa has given excellent results and these local therapies should be practiced for admirable results in the above-mentioned gynaecological problems.
Rasayan as a Public Health Tool at the time of Communicable Disease
Authors: Priyanka Dorage  , Ashish Thatere  , Ramraj Singh
Published: May 2023

Communicable diseases are illness caused by infectious agent or its toxins that spread from an infected person to normal person through the direct or indirect transmission. In Ayurved, communicable diseases are clearly mentioned under a broad term Janpadodhwansa and Aupasargik Roga according to Charak and Sushrut respectively. Most of the concepts of Janpadodhwansa are like etiology, mode of transmission and principles of prevention of outbreak etc. Are more likely corresponding to current theories about epidemic and pandemic. Immunity of an individual plays a major role in action of the infectious agent and development of further disease. “Rasayan Chikitsa” is therapy which produces the best quality of Rasaadi Sapta-Dhatus by increased Agni producing further the good quality of Ojas. Due to which the optimum Vyadhikshmatva is achieved, it further helps in controlling the disease condition. Rasayan also increases the longevity, mental, physical communicable diseases strength and improve quality of life. Activities of Rasayan botanicals on immune mechanisms and its antiviral activity provide a sound logic to use of these botanicals as a preventive major in the communicable diseases. Rasayan acts on both main manifestation of any diseases that is Manasika (psychosomatic) by Aachar Rasayan and Sharirik (body) by drug therapy. This review focuses on how communicable diseases can be prevent and control by Rasayan and how Rasayan help to improve public health. It also focuses on complications of communicable diseases which is major current challenge (in terms of Post COVID-19 syndrome) for Global Health system.
A critical review on concept of Niruha Basti formulation
Authors: Vijay Madhukarrao Maske  , Mayuri Narayanrao Manwatkar
Published: May 2023

Niruha Basti (decoction enema) has been given importance in classical texts of Ayurveda as well as is widely practiced by physicians as it can be given in patients of all ages and of all diseases. Basti formulation and administration greatly impact the therapeutic effects. The contents, their dosage, properties, order and method of mixing, characteristics of well-prepared Niruha Basti, rationality behind sequential mixing and need for Basti formulation should be studied thoroughly so as to understand the essence of science, to achieve desired therapeutic effects and to avoid complications. So, here is an attempt to understand the entire concept of Niruha Basti formulation with the help of references from classical texts, textbooks, previous articles on this topic from reputed journals.
A case study on the Ayurvedic management of Sixth (Abducens) Nerve Palsy
Authors: K.J. Najma Sultana  , Rathi S.
Published: May 2023

Abducens nerve (sixth cranial nerve) supplies the lateral rectus muscle of the eye. Abduction of the eye is carried out by the contraction of the lateral rectus muscle. The sixth cranial nerve palsy is a nonspecific sign of increased intracranial pressure and typically resolves following normalization of the intracranial pressure. Most of the patients with sixth nerve palsies experience diplopia. In the conventional practice, this phase is best managed by patching the paretic eye or by frosting a spectacle lens. As per Ayurveda, diplopia is told under Dwitiya Patalgata Timira by Acharya Vagbhata, whereas Acharya Sushruta has included diplopia under Tritiya Patalgata Timira. Case: A 32 year old female patient came to the Shalakya Tantra OPD of SJIIM, Bengaluru with complaints of difficulty in turning right eye away from nose i.e., crossing of eye inward towards nose; headache was constant over right frontal and retroorbital area since 3days with no history of diabetes mellitus and hypertension. She approached to an ophthalmologist and was advised for treatment modalities like occlusion of the eye or using prisms until the diplopia subsides, botulinum toxin injections. As the patient was uncomfortable for undertaking conventional method of treatment hence came to an Ayurvedic hospital to undergo treatment. Conclusion: Isolated 6th nerve palsy and its Ayurvedic management has provided satisfactory results and provided relief from the symptoms.
Nidanapanchakatmak study of Aamvata
Authors: Ashu  , Rakesh Sharma
Published: May 2023

In Ayurveda there are various approaches to diagnose a disease; the concept of Nidan Panchak is one such modality of Ayurveda. Nidan Panchak helps to diagnose diseases at various stages. Knowing the definite Nidana (etiological factors), Dosha vitiation, Samprapti (pathogenesis or progress of disease) and to check it at early stage is given prime importance. Nidan Panchaka plays vital role to identify types of disease. It consists of five subtypes which are Nidan (causes), Purvarupa (Prodromal Features), Rupa (Clinical features), Upashaya (Therapeutic methods), and Samprapti (Pathogenesis). These five elements collectively or selectively help in making an accurate diagnosis. Aamvata is a diseased caused by Dushti of Rasavaha Strotas in which there is formation of Ama due to Jatharagni Mandya. The Aamvata condition closely resembles with Rheumatoid arthritis, an autoimmune inflammatory condition characterised by symmetrical polyarthritis. Aamvata disease was first described in Laghutrayee by Acharya Madhava. Before the Acharya Madhava the concept of Aamvata was vague. Aamvata develops due to Dushti or Prakopa of Ama as well as Vata Dosha. As the disease Aamvata is very prevalent in society, it’s important to know the exact diagnosis along with treatment. In our current review we had tried to elaborate about the Nidanapanchaka of Aamvata.
PENGARUH TINGGI CELAH ALIRAN PADA SLUICE GATE TERHADAP KINERJA KINCIR AIR JENIS SUDU MELENGKUNG
Authors: Syahrial Ridho Dwi , Soenoko Rudy , Widodo Teguh Dwi , Sunarso Alfeus
Published: May 2023

This study aimed to determine the effect of adding the sluice gate and the optimal width of the sluice gate on the waterwheel performance. Tests have been carried out experimentally on a laboratory scale. In the test, this study used an open channel waterwheel with variations in the flow gap width gate width of 25mm, 35mm, and 40mm. Each variation of the flow gap width will be tested at a flow rate of 12 liters/second. Parameters such as mill power, turbine torque, and efficiency will be determined based on the measurement results of the rotational speed of the waterwheel wheel, water level, and braking load. The results showed that the width of the sluice gate flow gap affects the performance of the waterwheel. The highest performance was obtained at a flow gap of 25mm followed by a flow gap width of 35mm, and the lowest performance was obtained at a variation of the slit width of 40mm. The maximum performance of the waterwheel is obtained at variations in the width of the flow gap of 25mm at 50 rpm rotation conditions with a discharge of 12 liters/second where liters were generated 15.06 watts and the efficiency 29.82%.
RANCANG BANGUN GRIPPER ROBOT MANIPULATOR 2 DOF KAPASITAS 1,25 KGF
Authors: Sirojuddin Sirojuddin , Solikhah Siti , Sukarno Ragil , Tamami Muhammad Izaz
Published: May 2023

Manipulator robots practically help human to move objects vertically, horizontally, or rotationally. The robot is generally divided into three components, namely arm, base, and gripper with servo motor drive. The aim of this study is to improve the previous gripper robot manipulator design so that it can move 2 DOF (Degree of Freedom) by adding 1 DOF located on the robot gripper, which in previous studies, the robot manipulator gripper was only able to move 1 DOF. In addition, after calculating using Von Mises theory, then design 2D components and this assembly using AutoCAD software. Next design 3D components and assembly using Autodesk Inventor application based on FEM (Finite Element Method). Will also make a tool in the form of a robot gripper which will later be tested for feasibility. Based on the calculating result, the minimum thickness of the most significant link is 5.1 mm. To make it easier to find plates and save costs, the thickness of all plates in each link is rounded up to 6 mm. From the result of the movement simulation, it is found that the gripper can move open, clamp and rotate, and from the FEM software result the Safety factor value = 3.58 >3.0. Meanwhile, based on the result of the feasibility test, the gripper robot manipulator is feasible.
Analysis of Tensile Strength and Age of Gelatin-Based Polyamide Adhesive and Adipic Acid with Variation in the Amount of Borax as Anti-fungal.
Authors:   Departemen Teknik Kimia, Fakultas Teknik, Universitas Gadjah Mada, Zain Anisya Salsabila , Santosa Alvin Rizani Ardiansyah , Budhijanto Budhijanto , Pancasakti Bima Prasetya
Published: May 2023

Perekat yang banyak digunakan saat ini adalah perekat sintesis yang terbuat dari minyak bumi yang merupakan sumber daya alam tidak terbarukan yang saat ini cadangannya sudah mulai menipis. Oleh karena itu, pembuatan perekat berbasis bahan alami (bioadhesive) perlu untuk dilakukan. Salah satu perekat dari bahan alami adalah perekat poliamida yang merupakan hasil polimerisasi dari senyawa yang mempunyai gugus karboksilat dan amina. Pembuatan perekat dilakukan dengan mereaksikan asam adipat dan gelatin dengan bantuan katalis asam p-toluensulfonat. Selain itu, boraks sebagai anti jamur dan minyak sawit sebagai plasticizer juga ditambahkan. Reaksi polimerisasi dijalankan secara batch pada suhu 90℃ dan tekanan 1 atm dengan variasi rasio mol boraks:gelatin 0, 0,17, 0,2, 0,25, 0,33, 0,5, dan 1. Produk perekat diaplikasikan pada balok kayu dan diuji kuat tarik serta diamati pertumbuhan jamurnya. Hasil kuat tarik terbaik yaitu perekat dengan rasio mol boraks:gelatin 0,25 dengan nilai kuat tarik untuk curing time 1, 3, 7, dan 14 hari masing-masing adalah 1576, 2197, 3387, dan 3708 kPa. Sedangkan dari hasil pengamatan jamur, dapat diketahui bahwa penambahan mol boraks dapat menghambat pertumbuhan jamur pada perekat poliamida.
Study of the potency of citronella oil as an additive to fuels oil.
Authors:   Departemen Teknik Kimia, Fakultas Teknik, Universitas Brawijaya, Milenia Rohmah , Islam Livya Safira , Ihsan Muhammad , Sarosa Aji Hendra
Published: May 2023

Bahan bakar jenis pertalite merupakan salah satu bahan bakar produksi Pertamina dengan RON 90. Sedangkan, solar memiliki angka setana 48 dengan kualitas di bawah pertalite. Efektifitas bahan bakar dapat ditingkatkan dengan penggunaan aditif. Salah satu terobosan terbaru dalam penggunaan aditif ialah minyak sereh wangi. Minyak sereh wangi memiliki karakteristik yang menyerupai bahan bakar. Selain itu, minyak sereh wangi mengandung senyawa oksigenat yaitu sitronelal, sitronelol, geraniol yang berpotensi untuk menyempurnakan pembakaran bahan bakar dengan mengoksidasi karbon monoksida menjadi karbon dioksida. Jurnal ini meninjau keefektifan minyak sereh wangi sebagai aditif pada bahan bakar. Bahan bakar minyak akan ditinjau, diikuti peninjauan potensi minyak sereh wangi sebagai bahan aditif pada bahan bakar. Selain itu, pengaruh penambahan bahan aditif minyak sereh wangi terhadap nilai kalor, angka oktan, emisi karbon monoksida, serta efek pada mesin kendaraan juga ditinjau. Dari studi literatur ini, didapatkan bahwa penambahan minyak sereh wangi dalam konsentrasi yang tepat dapat meningkatkan nilai kalor dan angka oktan bahan bakar. Kenaikan ini bervariasi pada setiap konsentrasi zat aditif di dalam bahan bakar dan dipengaruhi pula oleh kombinasi zat aditif yang digunakan. Emisi karbonmonoksida dan kerak yang dihasilkan pada kendaraan bermotor berbahan bakar pertalite dengan penambahan minyak sereh wangi dalam volume yang tepat dapat berkurang.
Effect of Ozonation of Kapuk Seed Oil on Characteristics of the Esterification Product with the Assistance of Ultrasonication.
Authors:   Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Padjadjaran, Haryono Haryono
Published: May 2023

Minyak biji kapuk merupakan minyak non pangan sehingga sangat menguntungkan sebagai bahan baku pembuatan biodiesel. Namun minyak biji kapuk didominasi oleh asam lemak rantai panjang dan tak jenuh. Jenis asam lemak tersebut cenderung akan mengurangi kualitas biodiesel yang dihasilkan, yaitu rendahnya bilangan cetana dan dapat memicu reaksi polimerisasi selama pembakaran. Ozonasi dapat diterapkan untuk memperbendek rantai karbon dan jumlah ikatan rangkap pada asam lemak dari minyak biji kapuk. Penelitian ini bertujuan mempelajari pengaruh lama ozonasi pada tahap penyiapan minyak biji kapuk terhadap karakteristik produk dari tahap esterifikasi dengan bantuan ultrasonikasi. Waktu ozonasi divarisakan selama 60, 90, dan 120 menit. Esterifikasi dilakukan selama 30 menit pada suhu 60 oC dengan bantuan gelombang ultrasonik pada frekuensi 35 kHz. Hasil penelitian menunjukkan bahwa semakin lama waktu ozonasi dihasilkan minyak biji kapuk dengan bilangan asam semakin meningkat. Peningkatan bilangan asam dari minyak biji kapuk tersebut dan diverifikasi dengan komposisi asam lemak dari hasil analisis dengan Khromatografi Gas-Spektroskopi Massa, menunjukkan bahwa struktur asam lemak pada minyak biji kapuk menjadi lebih sederhana. Esterifikasi selama 120 menit terhadap minyak biji kapuk yang telah diozonasi dihasilkan fase minyak dengan bilangan asam 10,6 mg KOH/g, bilangan penyabunan 112 mg KOH/g, dan densitas 903 kg/m3.
Production Briquette from the Wood Powder and Dry Teak Leaf Using Molasses as Binder
Authors:   Program Studi Teknik Pengendalian Pencemaran Lingkungan, Politeknik Negeri Cilacap, Hidayat Rafi , Dwityaningsih Rosita , Haarjanto Taufan Ratri
Published: May 2023

Langkanya jumlah bahan bakar menyebabkan permasalahan terhadap pemenuhan sumber energi. Oleh karena itu, mendapatkan bahan alternatif penukar bahan bakar fosil yang..lebih..ramah lingkungan dilakukan. Serbuk kayu dan daun jati kering merupakan biomassa yang belum digunakan..secara optimal. Oleh karena itu dalam penelitian ini akan dilakukan pembuatan briket dari serbuk kayu dan daun jati kering. tujuan dari penilitan ini adalah untuk mengetahui kualitas briket serbuk kayu dan daun jati kering berdasarkan SNI 01-6235-2000. Pembutan briket dari serbuk kayu dan daun jati kering dengan menggunakan molase sebagai perekat dapat menjadi sumber enetgi alternatif. Penelitian ini menggunakan metode pirolisis pada suhu 300⁰C dengan variasi waktu 2 jam dan 3 jam pada serbuk kayu dan daun jati kering. briket yang telah jadi dilakukan pengujian nilai kalor, kadar abu, kadar air, nilai kerapatan, uji laju pembakaran, dan lama mulai terbakar sesuai dengan SNI 01-6235-2000. Dari hasil penelitian didapatkan briket dengan komposisi terbaik yaitu perbandingan serbuk kayu dan daun jati kering adalah sampel H dengan komposisi serbuk kayu 100%, perekat molase sebanyak 25 gram pada waktu pengarangan 3 jam, briket tersebut mempunyai nilai kalor 6197 kal/g, kadar abu 64%, kadar air 2,18%, kerapatan 0,77 g/cm3, laju pembakaran 4,85 g/menit, dan lama mulai terbakar 10 detik.
The Effect of Stevia rebaudiana Leaf Drying and Number of Soxhletation Cycles on Sugar Levels
Authors:   Departemen Teknik Kimia, Fakultas Teknik, Universitas Brawijaya, Zahro Haifatuz , Zaini Rifka Sabrina , Nurhadianty Vivi , Sarosa Aji Hendra
Published: May 2023

Stevia rebaudiana merupakan tanaman yang digunakan sebagai pengganti gula dengan tingkat kemanisan 200-300 kali lebih tinggi dan memiliki nol kalori sehingga aman untuk dikonsumsi. Stevioside dan rebaudioside A adalah salah satu komponen yang berperan memberikan rasa manis dalam daun Stevia. Penelitian ini bertujuan untuk mengetahui pengaruh pengeringan daun Stevia dan jumlah siklus soxhletasi terhadap kadar gula. Metode isolasi daun Stevia yang digunakan pada penelitian ini adalah soxhletasi dengan pelarut etanol 96%. Penentuan kadar gula menggunakan refraktometer dan identifikasi gugus fungsi menggunakan analisa Fourier Transform Infra Red (FTIR). Hasil penelitian menunjukkan pada siklus ke-3 didapatkan hasil terbaik untuk nilai kadar gula sebesar 44% untuk bahan segar dan 50% untuk bahan kering. Sehingga diketahui bahwa daun Stevia yang telah dikeringkan memiliki nilai kadar gula terbaik dibandingkan dengan bahan segar. Berdasarkan hasil spektra IR didapatkan gugus fungsi penyusun senyawa stevioside dan rebaudioside A.