bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review: Risk Management of Cloud Computing Projects in Healthcare
Authors: Fathullah Muhammad Afif , Subbarao Anusuyah , Muthaiyah Saravanan
Published: September 2023

Cloud computing has become a major driver for innovation in this technological age. All sectors around the world have increasingly moved towards cloud adoption including the healthcare sector. However, cloud computing projects with other IT projects come with their own set of risks that could be costly for organizations if they materialized. This study aims to provide an understanding of the risks of cloud computing projects in healthcare by using a systematic literature review augmented by the constant comparison method.63 articles from five major databases written from the year 2010 to 2022 were reviewed as they are related to cloud computing projects. More specifically, this study shows 198 unique indicators that were categorized into risks, threats, vulnerabilities, probabilities, consequences, and control procedure categories which then were classified into 13 distinct risk classes that can be found in such projects.
Macroeconomic Determinants of Non-Performing Loans in Malaysia
Authors: Tan Hui Ying , Tang Tuck Cheong
Published: September 2023

This study re-examines the macroeconomic variables those explaining the outstanding balance of non-performing loans (NPL) in Malaysia, namely interest rate, unemployment rate, output, and price level. It covers 11 financing sectors between commercial and Islamic banks, for examples, primary agriculture, electricity, gas and water supply, manufacturing, household sectors, and so on. The data covers monthly observations for the period 2019-2021. Given non-stationarity property in nature for the variables, the ordinary least square (OLS) estimator applies for the first-differenced variables. The empirical results show that higher output reduces overall NPL including of Islamic banks but is inelastic. The past NPL explains the recent outstanding balance. The macroeconomic variables explain the most for primary agriculture, construction, mining & quarrying, transport, storage & communication, and other sector. This study also provides some relevant policy implications.
Organizational Fear: Barriers to Effective Performance among Malaysian Fresh Graduates’ Employee
Authors: Leong Ling Ling , Chong Chin Wei , Rahman Muhammad Sabbir , Gan Geok Chew
Published: September 2023

The aim of this research study is to determine the factors, i.e., childhood socialization, institutional socialization, cultural socialization, fear of workplace penalty and afraid of getting terminated from work of organizational fear that influence the effective performance among the Malaysian fresh graduate employees. Data were collected from 119 fresh graduate employees who have their jobs in their first year in organization and data was analysed by using statistical analyses. The findings show that all the factors (childhood socialization, institutional socialization, cultural socialization, fear of workplace penalty and afraid of getting terminated from work) have significant relationships with effective performance. Among these, cultural socialization has the strongest relationship with effective performance. The empirical findings highlight factors of organizational fears that might affect the effectiveness of organizational performance. It also provides recommendations for organizations to reduce employee fear for better performance in achieving individual and company goals. This study provides insight into the important factors for organisational fear which ultimately lead to a better understanding to improve performance among fresh graduates’ employees in Malaysia.
The Necessity of Financial Literacy for Women Business Triumph: A Qualitative Study
Authors: Abdul Malik Nur Iylia Syafiqah Abdul Malik
Published: September 2023

Women entrepreneurs continue to be the torchbearers of society and nations in their pursuit of economic growth and social development through employment creation, innovation and poverty reduction. Nonetheless, financial literacy is an intangible resource that is required for growth, success, and long-term competitive advantage. However, a notable hindrance to the progress of women entrepreneurs is the absence of adequate financial literacy. The objective of this research was to ascertain the importance of financial literacy concerning the achievement of women entrepreneurs. In order to achieve the research objectives, a qualitative investigation was conducted, wherein interview data was gathered according to the OECD core competencies framework on financial literacy for entrepreneurs from a sample of twenty-three women entrepreneurs. The participants were selected based on the criteria of having a business that has been operational for at least five years. The results indicate that financial literacy considering the three dimensions assessed: financial knowledge, skills and attitude significantly influences the efficacy of women entrepreneurship. Consequently, it is recommended that women entrepreneurs engage in group-based and targeted training programmes to acquire the necessary skills to enhance their financial literacy.
Managing the Nigerian Economy through Fiscal Deficit
Authors: Bala Umar , Uba Badamasi Salihu , Haruna Adamu Yahuza
Published: September 2023

This study examined how fiscal deficit, exchange rate, and inflation rate impacted the economic growth of the Nigerian economy from 1980 to 2019. The cointegration connection in the study was discovered using the autoregressive distributed lag (ARDL) bound test. The analysis found that, while inflation and the exchange rate have a positive and significant relationship with the Nigerian economy, the fiscal deficit has a negative but relatively insignificant effect on the country's GDP. The Nigerian government should stabilise the currency's external value and prevent it from falling in value in the short term. Such policies should be developed to encourage people to pay taxes while providing incentives to those who abide. The government should lower lender interest rates to boost small domestic investors to make investments and create jobs while increasing government revenue. Government agencies should reduce luxuries and wasteful spending to avoid a fiscal deficit.
PENINGKATAN KEMAMPUAN PERSONEL BADAN INTELIJEN STRATEGIS (BAIS) TENTARA NASIONAL INDONESIA (TNI)
Authors: Hasmoro Boma , Bastari Bastari , Kustiawan Bambang
Published: September 2023

Operasi intelijen yang dilaksanakan pada dasarnya memerlukan sumber daya yang kompeten sehingga mampu menjalankan tugas-tugasnya dengan baik.  Badan Intelijen Strategis (BAIS) Tentara Nasional Indonesia (TNI) sebagai salah satu lembaga yang ditunjuk dalam tugas intelijen dituntut memiliki kesiapan di tengah kompleksitas persoalan yang dapat menimbulkan terganggunya stabilitas nasional. Namun demikian dalam pelaksanaannya BAIS TNI masih menghadapi berbagai persoalan, sehingga perlu penanganan yang serius agar pelaksanaan tugas dapat dilakukan secara optimal dan pada akhirnya mampu memperkuat pertahanan dan keamanan NKRI. Tujuan penelitian ini yaitu menganalisis peningkatan kemampuan personel BAIS TNI dalam memperkuat pertahanan negara.  Personel merupakan faktor penting dalam pencapaian tujuan suatu lembaga atau organisasi. Penelitian ini menggunakan penelitian kualitatif yakni data dikumpulkan melalui wawancara dengan para informan yang berasal dari berbagai instansi terkait. Selain itu, data yang digunakan juga berasal observasi dan dokumentasi. Hasil penelitian menunjukkan: 1) Kemampuan BAIS TNI dalam memperkuat pertahanan negara saat ini belum optimal, hal ini dapat dilihat dari belum optimalnya profesionalisme personel intelijen, terbatasnya jumlah personel, material khusus intelijen yang belum terintegrasi dengan baik dan peranti lunak yang belum optimal; dan 2) BAIS TNI dalam pelaksanaan tugas masih menghadapi berbagai hambatan dan tantangan seperti terkait kesiapan personel, penyediaan personel masih tergantung dari Angkatan baik TNI AD, TNI AL, TNI AU, dan sistem yang terbangun belum mencukupi dalam  upaya  peningkatan kemampuan personel BAIS TNI
Test Results of the Harvester Mounted “Don Mar ZhN-16”
Authors:   Kostanay Affiliate of LLP “SPC Agroengineering”, Kazakhstan, P.G. Ivanchenko
Published: September 2023

The test results of the mounted harvester “Don Mar ZhN-16” are given. The testing laboratory of KF LLP “SPC Agroengineering” recommended the mounted harvester “Don Mar ZhN-16” for use in direct combining with high-performance combines of the 5th and 6th class in the zone of Northern Kazakhstan.
Renewal of the Park of Agricultural Machinery With the Framework of the Departmental Project ‘‘Technical Modernization of the Agro-industrial complex’’
Authors:   Ministry of Agriculture of Russia, P.I. Burak , I.G. Golubev ,   Rosinformagrotech
Published: September 2023

Information is provided on the number of cars registered by state technical supervision authorities in 2021 and 2022. The share of equipment, from the year of production of which more than 10 years have passed, has been established. The dynamics of the acquisition of tractors, grain and forage harvesters by agricultural producers, as well as the energy supply of agricultural organizations is shown.
Assessment of Bangladeshi rice landraces for drought tolerance under controlled environment
Authors: Khalequzzaman M , Haq N
Published: September 2023

Drought is one of the major challenging abiotic stresses for rice production in Bangladesh. This study investigated 48 rice landraces obtained from different Eco-zones of Bangladesh for their drought tolerance characteristics. Significant variation was observed in morpho-physiological traits such as length of root and shoot, dry weight of root and shoot, leaf stomatal resistance and stomata number. Stomatal conductance, root length, root dry weight showed significant correlation with visual drought score. A cluster analysis based on morpho-physiological characteristics identified six cluster groups and most of the promising drought tolerance landraces were found in cluster VI. Five landraces - Dhapa, Dud Kalam, Dular, Hogla Pata and Keora showed key desired characteristics for dry weight, stomatal conductance, evapotranspiration, water use efficiency and root parameters for drought tolerance. These landraces could be potential sources in breeding program for the development of drought tolerant rice varieties.
Bangladesh Rice J. 26 (1): 1-16, 2022
Fabrication and Field Performance of Power Weeder for Mechanized Rice Cultivation in Bangladesh
Authors: Paul S , Rahman M A , Paul H , Rahman M M , Nath B C , Huda M D , Bhuiyan M G K
Published: September 2023

A study was aimed at modifying and manufacturing a power weeder at the local workshop using locally available material and evaluating its performance in the condition of Bangladesh.  The Bangladesh Rice Research Institute's Farm Machinery and Post-harvest Technology (FMPHT) division (BRRI) took the initiative to fabricate a power weeder using locally available materials. In the wetland of the BRRI research field and farmer's field at Jogitola of Gazipur district, the developed power weeder was tested during the boro season of 2017-2018. The average weeding efficiency of the power weeder was 80.38% and 81.43% at the research and farmers' field respectively. The percent of tiller damage was observed 2.78% and 2.81% respectively. 910 m2 h-1 (0.091 ha h-1) was the average effective field capacity of the power weeder. After 5 days, the percentage of weeds revived for power weeder was observed at 32.26% and 34.90% at the BRRI research and farmers' fields, respectively. Weed biomass was found 35.43 gm m-2 in a farmer’s field and 30.88 gm m-2 in the BRRI research field, Gazipur. This machine can be run by one man/woman easily. The weight of the complete weeder is 18.3 kg. The benefit-cost ratio of the weeder is 1.85. Farmers can use this weeder in wetland conditions. In the line transplanted wetland field conditions, the power weeder was found suitable for controlling weeds with minimum standing water.
Bangladesh Rice J.26 (1): 47-57, 2022
Variability and genetic gain prediction for maintainer line improvement of hybrid rice in Bangladesh
Authors: Quddus M R , Qayum M A , Lipi L F , Akter A , Kulsum M U , Islam M S , Hasan M J
Published: September 2023

Assessment of genetic variability in the nursery of the breeding population is essential for crop improvement successfully. Thirteen (13) maintainer lines of hybrid rice were evaluated to estimate the level of their genetic diversity and heritability of grain yield influencing parameters in the transplanted Aman, 2020 season. The studied traits were days to 50% flowering, total effective tillers plant-1, plant tallness (cm), length of flag leaf (cm), breadth of flag leaf (cm), panicle size (cm), filled grains panicle-1, unfilled grains panicle-1, growth duration (days) and grain yield (tha-1). Coefficient of variation (genotypic and phenotypic) was noticed high for most traits that revealed high variability among the studied genotypes. Broad-sense heritability ( ) was high in all traits except flag leaf breadth. Analysis of the cluster and its mean comparison showed that cluster 2 (i.e. BRRI 11B, BRRI 99B, IR 79125B and IR 79156B) represented the best agronomic traits and yield potentials. Therefore, selection of genotypes with valuable attributes from cluster 2 will be considered for maintainer line improvement programs. The use and estimation of predicted genetic gain will provide a visionary insight of the future genotypes produced after the crossing of the genotypes under study.  
Bangladesh Rice J. 26 (1): 69-78, 2022
The leisure practice of the youth in the “Gigante Crocodilo Prime” in Brazil
Authors: Rodrigues Mauro Costa , Couto Ana Cláudia Porfírio , Campos Emerson Araújo de , Rezende Fábio Henrique França , Ricardo Namuetcha Silva
Published: September 2023

The sound systems are mega-structures of electronic equipment used to liven up the parties held mainly on the outskirts of Belém, in the state of Pará, Brazil, being recognized as a cultural element, typical of this region and are mostly attended by young who are in the age group of 15 to 29 years old. The aim was to investigate the relationships established by young people during their leisure practices with the “Gigante Crocodilo Prime” sound system of Belém do Pará. The methodology has based on the qualitative approach and consisted of observing the leisure experience of young people in the context of sound system parties, and the data were analyzed by means of the content analysis technique, with the support of the NVivo software. It has been concluded that young people attend the sound system parties to develop a lifestyle taken by technology. Thus, the success and the effervescence of the sound system parties within the context of the outskirts of the city occur due to the development process of the parties themselves, which make their regulars being taken by a sort of sound frenzy that make them feel as if their bodies were being summoned to such venues.
Mecanisms of the chemical crosslinking to obtain the hydrogels: Synthesis, conditions of crosslinking and biopharmaceutical applications
Authors: Siqueira Edmilson Clarindo de , França José Adonias Alves de , Souza Ronny Francisco Marques de , Leoterio Dilmo Marques da Silva , Cordeiro José Nunes , Doboszewski Bogdan
Published: September 2023

Hydrogels are three-dimensional polymer matrices with recognized biomedical applications. Chemically crosslinked hydrogels offer greater mechanical stability than physically crosslinked hydrogels due to the covalent bonds between their polymeric chains. The preparation of hydrogels by chemical crosslinking involves three basic components: monomer, initiator and crosslinking agent, which must be present in proportions that do not alter the integrity of the hydrogel. The chemical crosslinking mechanism can be designed from reactions between complementary functional groups, ultraviolet light reactions, radical polymerization, high energy irradiation, among others. In this review, we revisit the chemical crosslinking mechanisms involving synthetic or natural polymers. Finally, biomedical applications of hydrogels are discussed, such as drug delivery, cell culture, tissue engineering, cancer therapy, among others.
Exodontia de terceiro molar: Caso clínico
Authors: Silva Oreste Maurilio da , Silva Larissa Carvalho
Published: September 2023

O estudo aborda a descrição de um de caso clínico de um paciente do gênero masculino, 26 anos, que apresentava um terceiro molar superior direito erupcionado. O paciente procurou tratamento na clínica da Faculdade Integrada Carajás, devido ao desconforto e a dor que sentia. Após exames clínicos e de imagem, incluindo radiografia panorâmica, foi indicada a exodontia do dente 18 devido à presença de lesão cariosa e inflamação gengival. Dentro do procedimento pela exodontia por via alveolar, utilizando extratores de Seldin reto e laterais, bem como o fórceps 18 R. Essa abordagem menos traumática proporcionou resultados satisfatórios, ressaltando a importância da realização adequada de exames clínicos e auxiliares pelo cirurgião dentista.
PENGEMBANGAN MEDIA POP UP BOOK DALAM PENGUASAAN KOSAKATA BAHASA ARAB DI MTS AL-MUSLIMUN NW TEGAL
Authors: Diniyati Auni Islahatun , Suparmanto Suparmanto , Rahmatul Wipqi Iska , Hadi Anggara Wiryan
Published: September 2023

ABSTRAK
Media Pop-Up Book merupakan sebuah alat peraga tiga dimensi yang dapat menstimulasi imajinasi anak serta menambah pengetahuan sehingga dapat mempermudah anak dalam mengetahui penggambaran bentuk suatu benda. Penelitian ini bertujuan untuk mengetahui adanya pengaruh dari penggunaan media pop up book dalam proses penguasaan kosakata bahasa Arab siswa kelas IX Khusus MTs Al-Muslimun NW Tegal. Jenis pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif. Penelitian ini berlokasi di MTs Al-Muslimun NW Tegal, beralamat di Jalan Pariwisata Desa Meninting, Kec. Batulayar Kabupaten Lombok Barat. Objek penelitian ini adalah siswa kelas IX Khusus MTs Al-Muslimun NW Tegal. Peneliti memperoleh data penelitian melalui wawancara, observasi, dan dokumentasi. Hasil penelitian ini menunjukkan bahwa media pop up book  telah memberi pengaruh yang positif dalam penguasaan kosakata bahasa Arab siswa kelas IX Khusus MTs Al-Muslimun NW Tegal. Pengaruh tersebut berupa penguasaan kosakata dalam bahasa Arab. Antusias, semangat, keaktifan, serta hasil penilaian tugas yang meningkat membuktikan bahwa media pop up book berpengaruh baik dalam penguasaan kosakata bahasa Arab siswa di kelas IX Khusus MTs Al-Muslimun NW Tegal.
Analisis Ilmu Arudh pada Syair "Qod Kafani" Karya Abdullah bin Alawi al-haddad
Authors: Abdul
Published: September 2023

Syair adalah ucapan atau tulisan dengan wazan atau bahr ber qafiyah dan elemen ekspresi rasa. Peneliti menggunakan metode deskriptif kualitatif dan melakukan studi kepustakaan. Tujuan dari penelitian ini adalah untuk mendeskripsikan jenis bahr dan zihaf yang ditemukan dalam Syair Qod Kafani, yang ditulis oleh Imam Abdullah bin Alawi bin Muhammad al-Haddad saat dia memiliki hajat kepada Allah SWT. Pendekatan yang digunakan untuk mengkaji beberapa pola yang ditemukan dalam syair ini adalah Ilmu Arudh. Dalam penelitian ini, studi pustaka digunakan sebagai metode pengumpulan data untuk mendapatkan informasi dari buku, artikel, makalah, atau sumber terpercaya lainnya yang relevan dengan topik penelitian. Peneliti menggunakan Divan al-ʼImam al-Haddad al-Durr al-Manzûm Lidzawi al-Uqûl wa al-Fuhûm, yang berisi kumpulan Syair sebagai sumber data pokok. Hasil penelitian menunjukkan bahwa Bahr Raml adalah jenis bahr yang digunakan dalam syair Qod Kafani oleh Imam Abdullah bin Alawi bin Muhammad al-Haddad. Disisi lain, terdapat dua jenis zihaf yang masuk ke dalam syair "Qod Kafani": Zehaf Khan dan Zehaf Kaff Thawil.

Kata kunci: Syair Qod Kafani, Ilmu Arudh, Bahr, Zihaf
PENERAPAN METODE MUROJA’AH BERSAMA DALAM PENINGKATAN KUALITAS HAFALAN ALQURAN PADA SANTRIWATI PPTQ DARUL FURQON MALANG
Authors: Mustaufir
Published: September 2023

Dalam mempertahankan dan meningkatkan kualitas hafalan Al-Quran yaitu dengan cara melakukan pengulangan secara teratur. Namun pada realitanya menjaga dan meningkatakan kualitas hafalan Al-Quran tidak semudah membalikkan telapat tangan. Seperti yang terjadi pada santriwati PPTQ Darul Furqon Malang dimana para santriwati melakukan pengulangan secara mandiri sehingga waktu yang tersedia kurang efektif dan kurang maksimal. Maka peneliti bersama para pengurus mencoba menggunakan metode murojaah bersama untuk memfasilitasi santriwati dalam memanajemen waktu dan efektifitas murojaah. Adapun tujuan penelitian ini adalah : 1). Mengetahui bagaimana penerapan metode murojaah bersama dalam peningkatan kualitas hafalan Al-Quran, 2). Mengetahui bagaiamana kualitas hafalan santriwati dengan penerapan metode murojaah bersama. Metode kualitas digunakan untuk mendeskripsikan situasi dengan data observasi, wawancar dan dokumentasi. Hasil penelitian dengan penerapan kualitas hafalan santriwati PPTQ Malang yaitu : 1). metode murojaah bersama dilaksanakan setiap pagi dan sore hari dengan dipandu 1 santriwati secara bergiliring sampai hatam 30 juz, 2). Dengan penerapan metode murojaah bersama ini tampa perkembangan, antara lain : 1). para santriwati lebih tertib dalam mengatur waktu, 2). Para santriwati dengan mudah dapat mengoreksi kesalahan pada aspek bacaan dan urutan hafalan.
تطبيق أسلوب التدريبات (Drill) لتحسين مهارة الكلام لدى طلاب الصف الثامن ه بمدرسة منبع الصالحين المتوسطة سوجي منيار غرسيك
Authors: Ridwan Muhammad Farih
Published: September 2023

ABSTRAK

Terdapat kebutuhan akan Bahasa Arab, akan tetapi kualitas peserta didik rendah, dan ini terjadi pada siswa kelas 8 MTs Mamba’us Sholihin. Oleh karena itu peningkatan harus dilakukan dalam pembelajaran bahasa Arab dengan menggunakan teknik Drill agar proses pembelajaran berjalan dengan baik dan memberikan hasil yang lebih baik. Berdasarkan latar belakang tersebut, dalam proses pembelajaran harus ada teknik yang digunakan agar siswa dapat memahami segala sesuatu yang diajarkan dan mencapai tujuan pembelajaran. Penelitian ini merupakan penelitian kualitatif dengan jenis penelitian tindakan kelas. Penelitian tindakan kelas merupakan kegiatan mengamati objek dengan menggunakan kaidah metodologi tertentu untuk memperoleh data dan informasi yang berguna. Teknik analisis data menggunakan reduksi, penyajian data dan penarikan kesimpulan.

            Hasil dari penelitian ini adalah bahwa prosentase rata-rata peningkatan kemampuan berbicara siswa terus meningkat pada setiap pertemuan. Namun pada siklus I prosentase skor rata-rata tidak mencapai target yang ditetapkan yaitu sebesar 25%. Kemudian pada siklus II prosentase hasil rata-rata mencapai 62,5%. Dalam hal ini dapat dikatakan tidak ada lagi kendala dalam proses pembelajaran dan penggunaan media pembelajaran pada penerapan teknik drill terbukti dapat meningkatkan keterampilan berbicara siswa kelas 8 MTs Mamba’us Sholihin. Kemudian rata-rata kenaikan antara prosentase dari siklus pertama ke siklus kedua adalah 81,25%.

Kata kunci: Metode drill, keterampilan berbicara.
High incidence of partial colony mortality constrains realized growth for three coral species in southeast Florida
Authors: Jones NP , Pratchett MS , Milligan RJ , Gilliam DS
Published: September 2023

Coral colony growth rates are a key demographic trait which can reveal fundamental changes in population health and resilience. With changing environmental conditions, assessing spatial, temporal and taxonomic variation in net coral growth is fundamental to understanding the changing structure of coral assemblages, particularly in high-latitude reefs which may provide refugia against climate change impacts. The high-latitude Southeast Florida Coral Reef Ecosystem Conservation Area (ECA) recently experienced mass coral mortality from heat stress and disease, and most remaining coral colonies are small. It is unclear whether the preponderance of small colonies is due to slow growth rates, high partial colony mortality or high colony turnover. To assess this, the net growth rates of 3 abundant species were quantified interannually between 2000 and 2020. Of 136 tracked colonies, 33% died and a further 61% had partial mortality. Small Montastraea cavernosa and Porites astreoides colonies generally grew faster than large colonies and had less partial mortality, but Siderastrea siderea consistently had high partial mortality. M. cavernosa and S. siderea net growth rates generally declined following excess heat stress or disease outbreaks, which caused partial and whole colony mortality, but growth rates in all species were negligible even during inter-disturbance periods. Maximum annual growth rates of each species aligned with those found in the Caribbean, but mean growth rates were low and confidence intervals included zero (linear extension, mean ± SD: M. cavernosa = 0.03 ± 0.6 cm yr-1; P. astreoides = 0.2 ± 0.6 cm yr-1; S. siderea = 0.1 ± 0.3 cm yr-1). As a result, coral growth and colony size is significantly constrained, preventing reef growth. Without profound changes in the environmental conditions, recovery capacity will continue to be severely limited.
Treatment optimization for breast cancer patients according to age and tumor subtype
Authors:   , Dackus Gwen Maria Hubertina Elisabeth
Published: September 2023

In this thesis entitled 'Treatment optimization for breast cancer patients according to age and tumor subtype', we show that optimizing breast cancer treatment is possible in various ways and different settings.
The investigation of prognosis and prognostic biomarkers enables us to identify which women need adjuvant systemic treatment. In part I of this thesis we describe the design of a study on young adjuvant treatment naïve breast cancer patients (chapter 1) which allows us to study the unbiased prognosis of these women (chapter 2). In addition, we explore and validate promising prognostic biomarkers (chapter 2 and chapter 3), all with the goal of treatment optimization.
When adjuvant systemic treatment is deemed necessary there are often several treatment options. Based on tumor characteristics, predictive biomarkers or a combination thereof, the best treatment for an individual patient is selected. In Part II of this thesis, we describe three studies (chapter 4 – chapter 6) which investigated the effectiveness of already existing treatments in patients who were usually excluded from the large randomized controlled trials.
Lastly, improvements can also be made in the metastatic setting, for instance by combining already existing treatment modalities. In part III we describe the study design of the REVIVAL study (chapter 7), a phase-Ib study on the safety of the olaparib-carboplatin treatment combination following a change in olaparib formulation (chapter 8).
THE FEATURES OF FORMING THE ECOLOGICAL CONSCIOUSNESS OF A PERSON
Authors: HNATYUK VITALIY , PSHENYCHNA NATALIA , OTYCH DARIIA , KARA SVITLANA , POTAPCHUK HANNA
Published: September 2023

In recent decades, people have faced a severe threat of an ecological catastrophe, primarily due to the conflict between culture and the laws of nature. Society has exceeded the capabilities of the biosphere. In this context, there is a need to make all aspects of social life more environmentally friendly, including developing and implementing resource-saving and waste-free technologies, which requires the active participation of ecologically conscious persons. The environment must be provided with the necessary resources for carrying out socially significant work. Knowledge of the interactions between society and the environment, understanding the immediate and long-term consequences of natural changes, appreciation, conservation of natural resources, and love for nature are essential. Technological progress has improved people's financial lives, but unfortunately, it has caused significant damage to the entire biosphere. In these conditions, the understanding of contradictions arising in the "nature-conscious society" sphere lags behind the constant growth of conflicts. Resolving the ecological problems of the current stage of social development requires a new worldview and the formation of people's thinking and attitudes toward the major issues of human life. The formation of this ideology allows people to recognize their honesty and naturalness and transform consumer relations into sustainable consumption. Despite society's attempts to reflect its actions against nature, people's perceptions of the world are still distorted, their natural behavior is ecologically abnormal, and people are not yet ready to actively work in harmony with nature. Therefore, the relevance of the research topic is determined by the need for a deep and comprehensive analysis of information on the formation of ecological consciousness in the context of natural social development. Theoretical research enables the creation of a broad concept of environmental consciousness and the revelation of its nature, functions, and role in the development of the environment. The article hypothesizes that the formation of ecological consciousness depends on the person's age. Based on a sociological study conducted by the Ilko Kucheriv Democratic Initiatives Foundation on behalf of the Environmental Law Association, problems of forming ecological consciousness and age-specific features of ecological perception were identified. As a result, forms and methods of creating ecological consciousness for different age groups were developed: children (preschoolers), adolescents (schoolchildren and students), and adults. The article emphasizes the necessity of educational and awareness-raising activities among the people of each age group to form ecological consciousness effectively.
Assessing the Relationship Between Vitiligo and Cardiovascular Disease Risk Factors
Authors: Rahman Syed Minhaj , Wang Matthew , Ahmed Fahad , Jafferany Mohammad
Published: September 2023

Advancements in novel combination immunotherapies as well as innovative downstream management courses offer great optimism for the applicability of emerging cancer immunotherapy to prospective treatment of cold tumours. This review comprehensively analyses and discusses notable current research directions in the field and underscores future directions for continued scientific progress alongside relevant clinical applications. Vitiligo is an autoimmune disorder characterised by white depigmented cutaneous macules. Although vitiligo may generally be considered a cosmetic disease, literature has associated broader systemic comorbidities, including a higher risk for atherosclerotic events, dyslipidaemia, and cardiovascular risk. To the authors’ knowledge, this is the first systematic review that assesses the association between vitiligo and cardiovascular disease (CVD)/CVD-associated factors. Utilising the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the authors searched PubMed and Scopus databases to identify studies available as of 30th June 2022, examining CVD and CVD-associated risk factors in patients with vitiligo. Of 2,553 articles, seven studies (four cross-sectional and three case-control), totalling 611 patients diagnosed with vitiligo (56.3% female), met the inclusion criteria for the authors’ review. Six studies suggested a significant association between patients with vitiligo and an increased risk for CVD via increased atherosclerotic events, constraint-induced movement therapy, plaque presence, dyslipidaemia, high-sensitivity C-reactive protein, oxidative stress, as well as decreased levels of vitamin D, calcium, zinc, and antioxidants. However, one study found that patients with vitiligo presented with fewer cardiovascular risk factors and increased levels of high-density lipoprotein. Although few studies indicated an increase in atherosclerotic risk due to elevated low-density lipoprotein-cholesterol and total cholesterol, contradictory high-density lipoprotein and total cholesterol levels in additional studies indicate the need for further investigation. Lastly, the association between vitiligo severity and CVD risk also indicated conflicting results. The authors’ small sample size restrained their ability to compare populations and incorporate racial and ethnic diversity to generalise their conclusions. Additional studies are required to comprehensively understand the association between vitiligo and the risk of CVD.
Overcoming Communication Barriers to Facilitate Healthcare Access for People with Intellectual Disability
Authors: Teo Joy
Published: September 2023

Communication barriers are one of the many reasons why People with Intellectual Disability (PWID) are prevented from accessing appropriate healthcare services. As a result, the health of this population is poorer than the general population in many countries around the world. Understanding the nature of the limitations faced by PWID in language learning and communication forms the basis of creatively developing strategies to overcome them. Building bridges of understanding between the clinician and the PWID increases the chances of accurate diagnoses of health conditions, effective treatment, and an overall improved quality of life for the patient.
Security Implementation Testing of Remote Terminal Unit for Power Utility
Authors: Kapoor Shailesh , Priyanka R. , Agarwal Shyam , Pradish M.
Published: September 2023

The Indian power sector is undergoing a transformation by implementing digital technologies to deal with the major challenges of higher AT&C losses. Implementation of digital technologies requires the use of various communicable devices as a part of the Operational Technology (OT) system that enables real-time monitoring and control of the power sector. In order to access information from external networks, these technologies connect the OT systems with Information Technology (IT) systems, which exposes the OT systems to potential cyber-attacks. Therefore, it is essential to validate the security implementation of OT devices to mitigate the risk of cyber-attacks on OT systems. Electricity distribution utilities are implementing a substation automation system, and one of the major components of a substation automation system is Remote Terminal Unit (RTU). This paper explains the importance of cyber security requirements, OT system security challenges and security implementation testing of Remote Terminal Unit (RTU) as per IEC 62351 standards.
Artificial Intelligence's Role in Enhancing Conflict Resolution within the Online Dispute Resolution (ODR) System
Authors: Candeias Teresa De Jesus
Published: September 2023

This essay discusses the paradigm of the Online Dispute Resolution (ODR) system within the judicial context, highlighting the relevance of digital platforms for the efficient resolution of legal disputes. The influence of arbitration rules as the foundation for ODR is analyzed in detail, emphasizing how the effectiveness of these platforms is intrinsically linked to the strategic integration of a diverse range of functionalities. Special attention is given to the revolutionary power of Artificial Intelligence (AI) in this scenario, examining how advances in AI have the potential to enhance decision-making and virtual mediation. By skillfully intertwining the principles of arbitration with technological possibilities and the capacity of AI, this study not only sheds light on the future of conflict resolution but also piques the interest of a broad audience interested in the intersection of law, technology, and innovation.
Platelet Activating Factor Acetylhydrolase (PAF-AH) activity : could it have a role on coagulation in covid-19 patients?
Authors: BAYRAK Tülin , ŞENER Gülsen , SAĞLAM GÖKMEN Emel , BAYRAK Ahmet
Published: September 2023

Objective: Abnormal immune inflammatory response and cytokine storm play an important role on the aspect of increasing mortality in Covid-19. We aimed to investigate whether the Platelet Activating Factor Acetylhydrolase activity (PAF-AH) and hematological parameters have prognostic and predictive value in determining the disease severity.

Methods: A total of 84 Covid-19 patients, 52 of whom were hospitalized in the ward and 32 in the intensive care unit (ICU), and 38 control patients were included in this study.

Results: Lymphocyte and serum albumin levels were significantly lower (p < .001) and age, neutrophils, CRP, procalcitonin, LDH, INR, D-dimer levels were significantly higher (p < .001) in Covid-19 patients compared to the control group. ICU patients had significantly lower (p < .001) lymphocyte, albumin values and significantly higher (p < .001) age, leukocyte, neutrophils, CRP, INR, aPTT, D-dimer levels compared to ward patients. PAF-AH activity was significantly increased in ICU patients compared to the control group (p < .05). A positive correlation was found between PAF-AH and D-Dimer in the ICU group.

Conclusion: We found increased PAF-AH activity in patients with Covid-19. It’s important to spot the PAF-AH activity in cardiovascular events that develop due to coagulation problems, which are likely to be seen on these patients in the future.
Reliability, Concurrent Validity, and Minimal Detectable Change of a Smartphone Application for Measuring Thoracic Kyphosis
Authors: ŞAHİNOĞLU Ertan , ERGİN Gülbin , BAKIRHAN Serkan , ÜNVER Bayram
Published: September 2023

Objective: To assess the intra- and inter-rater reliability and concurrent validity, and to estimate minimal detectable change of a smartphone application for measuring thoracic kyphosis angle.

Methods: A total of 80 healthy university students were evaluated. Two raters measured the thoracic kyphosis angle using a digital inclinometer and the smartphone application. Intra- and inter-rater reliability were assessed using the intraclass correlation coefficient (ICC) with 95% confidence interval. The standard error of measurement (SEM) and the minimal detectable change at the 95% confidence level (MDC95) were also calculated. The concurrent validity between the digital inclinometer and the smartphone application was assessed by the linear regression analysis and Bland and Altman's 95% limits of agreement method.

Results: The intra- and inter-rater reliability were excellent for the digital inclinometer and the smartphone application (ICC > 0.75). The SEM values for the digital inclinometer and the smartphone application were close together. The MDC95 values for the smartphone application were 5.11 and 6.30 degrees, and 9.02 degrees for intra- and inter-rater, respectively. The digital inclinometer and the smartphone application showed a positive correlation (R2 = 0.85). The Bland-Altman plot showed a good agreement between the instruments.

Conclusion: The smartphone application used in this study is a cost-effective, practical, reliable, and valid instrument for measuring the thoracic kyphosis angle. More than 9 degrees in the value of the thoracic kyphosis angle measured by the smartphone application can be considered as a true change.
Nasal Sprays Containing Mometasone Furoate Can Be Used Prophylactically in COVID-19 Infection and Related Smell Disorders
Authors: ENÖZ Murat , ÖZDEMİR Mücahit , YALCİN Bahattin
Published: September 2023

Objective: We aimed to emphasize the possible beneficial effects of intranasal sprays containing mometasone furoate, especially for preventive treatment or supportive treatment in patients with olfactory disorders due to damage to the olfactory area, or for regular use in healthcare workers with a high risk of close contact.

Methods: Preventive and therapeutic scientific studies are continuing around the world for viral spread and viral damage associated with the Coronavirus disease 2019 (COVID-19) pandemic. We investigated the attachment of the COVID-19 virus in the nose and entry into the body with the crystal structure of the spike and Angiotensin-Converting Enzyme 2 (ACE-2) proteins, a molecular docking study. This scientific study is the first in-silico study to investigate the possible antiviral effects of Mometasone furoate molecules on spike protein and to show the antiviral effect of mometasone furoate on COVID-19.

Results: We think that nasal sprays containing mometasone furoate can be used prophylactically in patients with COVID-19 infection due to its antiviral effect, and it may be beneficial to use sprays containing mometasone furoate before the symptoms of upper respiratory tract infection begin in patients.

Conclusions: The role of these molecules in the treatment of acute smell disorders associated with COVID-19 infection and their antiviral effects on coronavirus should be investigated by conducting extensive scientific studies on the subject.
Effect of Reboxetine Treatment on BDNF, Synaptophysin, and PSD-95 Levels in the Spinal Dorsal Horn of Rats with Diabetic Neuropathy
Authors: TURAN YÜCEL Nazlı , ÜÇEL Umut İrfan , DEMİR ÖZKAY Ümide , ULUPINAR Emel , CAN Özgür Devrim
Published: September 2023

Objective: It is known that neuropathic pain is accompanied by alterations in the levels of neurotrophic factors and synaptic proteins in the microenvironment of the spinal dorsal horn. Such changes contribute to hyperalgesia and allodynia processes; thus, analgesic drugs can exert their pharmacological effects by affecting the expressions, levels, or functions of these endogenous substances. In this study, based on the knowledge that reboxetine (a selective noradrenaline reuptake inhibitor) has the potential for antihyperalgesic efficacy in diabetic neuropathy, we aimed to examine the probable effects of this drug on diabetes-induced changes in brain-derived neurotrophic factor (BDNF), synaptophysin (the pre-synaptic marker of synaptic integration), and postsynaptic density-95 (PSD-95) (the postsynaptic marker of synaptic integration) levels in the superficial laminae of the dorsal horn.

Methods: Experimental diabetes was induced by a single-dose injection of streptozotocin (STZ) (50 mg/kg) in rats. After four week-long induction period of painful diabetic neuropathy, rats were treated orally with 8 mg/kg reboxetine for two weeks. Hyperalgesia responses were evaluated by using the Randall–Selitto and Hargreave's tests. Following the pain tests, immunohistochemical studies were performed.

Results: Two weeks of reboxetine administration increased the reduced paw withdrawal thresholds and shortened the paw withdrawal latencies of diabetic rats in neuropathic pain tests, indicating the antihyperalgesic efficacy of this drug. Moreover, augmented BDNF and synaptophysin levels in diabetic rats reversed by reboxetine treatment. However, there was no alteration in the densities of PSD-95, in both STZ-diabetic and reboxetine-treated STZ-diabetic rats.

Conclusion: The obtained results suggested that inhibition of central sensitization and modulation of spinal plasticity seem to be pharmacological mechanisms underlying reboxetine's antihyperalgesic effects on diabetic rats. However, further studies are still needed to clarify the exact mechanism of action.
Initiation and Training of Adolescent Health Cadres of Poskestren in Mantikulore District City of Palu
Authors: Kusumawati Dwi Erma , Ansar Ansar , Adhyanti Adhyanti
Published: September 2023

Health promotion in adolescents is one of the alternative solutions to improve the health status of the community. Efforts that can be made in Islamic boarding schools are through the revitalization of Poskestren and adolescent health cadres . This activity aims to initiate and train youth health cadres in Islamic boarding schools. The activity was carried out in September 2021 at the Hidayatullah Tondo Islamic Boarding School and the Liwa'ul Haq Islamic Boarding School in Palu City. The method of activity is through surveys, brain storming and discussion,  simulations and demonstrations. The results show that pesantren health posts (Poskestren) have been successfully established in 2 activity locations. There is an increase in the knowledge of Poskestren cadres from before being given training compared to after being given training. It is recommended that this activity can be continued and the need for further training activities with other contents such as basic health, environmental health, reproductive health and others.
Workshop On The Implementation Of Balanced Nutrition Messages To Prevent Anemia In Female Adolescent
Authors: Aslinda Wery , Faisal Elvyrah , Asriani  , Bahja
Published: September 2023

Adolescents are the nation's assets for the creation of a better future generation. Adolescence is a time of rapid changes in terms of physical, cognitive, psychosocial or behavioral growth. Female adolescent often experience problems, one of which is anemia. Anemia is a deficiency (deficiency) of red blood cells due to low hemoglobin levels in the body. Anemia that occurs in female adolescent can interfere with the process of growth and development. The purpose of this community service is to increase the knowledge and awareness of female adolescent regarding balanced nutrition messages and anemia. The method used is public education by utilizing the media (food model). The results of this activity showed that 30.5% of female adolescent had anemia, 41,7% of female adolescent with good knowledge, and increased to 93,3% after training. The conclusion of this community service activity is that there is an increase in knowledge and awareness of female adolescent related to anemia by implementing a balanced nutrition messages. Through this activity, participants are expected to maintain a healthy lifestyle with balanced nutrition guidelines and make efforts to prevent anemia.
Design and Accuracy Test of Digital Body Circumference Measurement
Authors: Adhyanti  , Faisal Elvyrah , Irfan Niralda Widya Santika , Lewa Abd. Farid
Published: September 2023

Assessment of nutritional status is an important thing related to a person's level of health in order to prevent malnutrition and the risk of becoming undernourished. The tool that is often and commonly used to measure body circumference is a manual meter. This measuring tool is useful for measuring body circumferences such as upper arm circumference measurements for pregnant women, women of childbearing age (WUS) and adolescent girls, head circumference in infants, and abdominal circumference measurements for adult women and men. Measurement using a manual meter still takes a lot of time and is less practical. the purpose of this community service is to design and test the accuracy of digital body circumference measuring instruments. The method of this activity is the diffusion of science and technology to produce a digital body circumference measurement tool. The results of this activity indicate that the use of a digital body circumference measuring instrument has been successfully carried out and is used with a correlation coefficient value of > 0.6 so that the digital body circumference measuring instrument has good accuracy for measuring body circumference. The conclusion of this activity is that the digital measuring instrument has been successfully used and is declared accurate and can simplify and make it more practical when used in measurements.
ОБ ОДНОМ ЗАГАДОЧНОМ АНТРОПОЛОГИЧЕСКОМ ФЕНОМЕНЕ
Authors: Пестряков Александр
Published: September 2023

В статье рассматривается предположение о возможной связи между
количеством гласных звуков в языке и строением черепа носителей языка.
По данным автора показатель высоты свода черепа коррелирует с вокализа-
цией языка, однако о надежности и достоверности этой кореляции не позво-
ляет сделать вывод величина выборки. Дальнейшие исследования смогут
подтвердить или опровергнуть существование замеченной тенденции.