bluuebunny/crossref_metadata_2025 huggingface dataset:
VIDEO-ASSISTED THORACIC SURGERY USING LOCAL ANESTHESIA IN LUNG ABSCESSES AND PYOPNEUMOTHORAX
Authors: Akopov A. L. , Egorov V. I. , Deinega I. V. , Ionov P. M.
Published: July 2019

The article presents the results of 42 video-abscessoscopies (VAS) in acute and gangrenous lung abscess and 32 video-thoracoscopies (VTS) in pyopneumothorax, which were performed using local anesthesia and sedation. There were several indication to operation: sanation of cavities, removal of necrotic sequestration and fibrin, decollement, biopsy. Perioperative complications developed after 11 surgeries (13%): emphysema of soft tissues of pectoral cells (5), phlegmon of the thorax (3), bronchial hemorrhage (2), pneumothorax (1). One of the patients died, because of progressing of main disease. VAS and VTS were carried out in 5-8 days after cavity drainage of abscess or pleural cavity in 50 patients. In other 15 cases operations were performed directly before drainage. The bronchial hemorrhage and phlegmons of the thorax were noted in patients of second group. The patients had good tolerance of VAS and VTS operations fulfilled using local anesthesia and sedation. They are safe in case that operation follows drainage of abscess or pleural cavity after decrease of inflammatory processes.
APPLICATION OF INTRAGASTRIC BALLOON IN TREATMENT OF PATIENTS WITH OBESITY AND METABOLIC SYNDROME
Authors: Neimark A. Ye. , Popova V. F. , Anisimova K. A.
Published: July 2019

The bariatric surgery is the most effective way of obesity treatment. The article describes an experience of placement of intragastric balloon as an additional method of treatment to diet and medicamentous therapy in one group of patients. At the same time, there was the other group, where intragstric balloons were placed before bariatric surgery as measure of preoperative preparation.
FEATURES OF LYMPHADENECTOMY PERFORMANCE IN PATIENTS WITH STOMACH CANCER IN RADICAL SURGERY IN CASE OF VARIANT STRUCTURE OF CELIAC TRUNK
Authors: Sedov V. M. , Danilov I. N. , Yaitskiy A. N. , Zakharenko A. A. , Vovin K. N. , Bykova A. L.
Published: July 2019

The authors developed and described an algorithm and technical aspects of lymphadenectomy performance in radical surgery based on structural variations of visceral vessels in 91 patients with stomach cancer. Preoperative helical computer tomography in regimen of angiography was carried out on 91 patients. Variant anatomy of visceral vessels was detected in 31 patients and that required change of surgical technique inorder to minimize intraoperative risks of great vessel damage and allowed performing lymphadenectomy successfully.
PREVENTIVE COLOSTOMY IN PLANNED TREATMENT OF PATIENTS WITH RECTAL CANCER
Authors: Maistrenko N. A. , Khvatov A. A. , Sazonov A. A. , Petrov S. N.
Published: July 2019

The article described an original method of forming preventive colostomy, which reduced the rate of incompetence of interintestinal anastomosis in sphinctersaving resection concerning rectal cancer. This also facilitated patient’s rehabilitation in early postoperative period.
NEW METHOD OF PARTIAL NEPHRECTOMY WITH SELECTIVE PARENCHYMA CLAMPING
Authors: Al’-Shukri S. Kh. , Mosoyan M. S. , Semyonov D. Yu. , Esayan A. M. , Il’In D. M.
Published: July 2019

The authors suggested a new method of performance of open, laparoscopic and robot-assisted partial nephrectomy using specially developed instruments for selective parenchyma clamping in order to improve the functional results of renal cell carcinoma treatment. The operation with clamping of renal vessels was carried out in 86 cases and clamping of renal parenchyma was used in 24 cases. It was shown, that the open, laparoscopic and robot-assisted partial nephrectomy could be safely performed in conditions of selective ischemia of the renal parenchyma without clamping of renal vessels.
ULTRASONIC ASSESSMENT OF DIAPHRAGM CONDITION OF THE PATIENTS, WHO PASSED THE SELECTION FOR LUNG VOLUME REDUCTION SURGERY
Authors: Gorbunkov S. D. , Varlamov V. V. , Gichkin A. Yu. , Perley V. E. , Chernyi S. M. , Romanikhin A. I. , Syrovnev V. A. , Agishev A. S. , Akopov A. L.
Published: July 2019

The article showed the results of ultrasonic assessment of topographic and functional diaphragm indices in patients with severe diffuse emphysema. They passed the selection for lung volume reduction surgery. The comparison of diaphragm indices was presented in patients with diffuse emphysema and control group of healthy volunteers. Dynamics of diaphragm condition was studied after surgical treatment. There wasn’t noted any statistical difference of diaphragm topographic indices as compared with the control group. There wasn’t shown a correlation between respiratory function indices and functional diaphragm indices, but it was noted a positive tendency in characteristics during quiet breathing.
LONG-TERM RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH FOLLICULAR TUMORS OF THE THYROID
Authors: Zubarovskiy I. N. , Mikhailova M. V. , Osipenko S. K.
Published: July 2019

The article analyzed an experience of treatment of 51 patients with follicular tumors. It was proved, that there weren’t any complications and recurrences in case of typically performed operation and adequate replacement therapy in postoperative period. It was noted a good quality of life from 2 to 5 years.
PROGNOSIS OF DEEP INFECTIOUS COMPLICATIONS IN HIP ARTHROPLASTY
Authors: Dorofeev Yu. L. , Ptashnikov D. A. , Tkachenko A. N. , Bakhtin M. Yu. , Kalimullina A. F.
Published: July 2019

The retrospective research analyzed the data of 893 patients undergoing total hip arthroplasty. There were used the data about patients undergoing hip arthroplasty without complications (the first group - 808 cases) and patients with developed deep surgical site infection following total joint arthroplasty after 12 months (the second group - 85 patients). It was applied as the training matrix in creation of mathematical prognosis and algorithm of prophylaxis of deep infection in patients undergoing the primary total hip arthroplasty. There were revealed 21 prognostic significant criteria of deep infection development in surgical site. The program was tested in prospective investigation (293 clinical cases) with follow-up term of 12 months after operation. The rate of development of postoperative deep infection in surgical wound reduced as compared with the rate in group of retrospective research from 1,7% to 0,7%. The efficacy of proposed program was 80%.
ASSESSMENT OF EFFICACY OF TEMPORARY EPICARDIAL BIVENTRICULAR RESYNCHRONIZATION PACING AFTER CARDIAC SURGERY
Authors: Khubulava G. G. , Naumov A. B. , Marchenko S. P. , Suvorov V. V. , Averkin I. I. , Didenko M. V. , Pasenov G. S.
Published: July 2019

The temporary pacing is provided as a key principle of maintenance and correction of hemodynamics after weaning the patient from cardiopulmonary bypass. There are conventional algorithms of temporary pacing, but the substantiation of electrode fixation areas is variable. The authors experimentally investigated the efficacy of temporary epicardial pacing in DDD and DDDBV using 18 laboratory animals after cardiac surgery with application of cardiopulmonary bypass. The hemodynamic parameters were compared in given groups. It was noted that in case of temporary epicardial pacing in DDDBV conditions was the best hemodynamic effect. The authors recommended more optimal areas for electrode fixation in temporary pacing: bachmans bunble (closest to the artrial septum), proximal part of the crista terminalis for the right atrium electrodes; the front-side free wall of the right ventricle at the distance of 3-4 cm from the apex of the heart, diaphragmatic surface of the right ventricle proximal to artioventricular groove for the right ventricle electrodes; obtuse margin (side wall of the left ventricle), diaphragmatic surface of the left ventricle proximal to artioventricular groove for the left ventricle electrodes.
ORGANIZATIONAL AND TACTICAL FEATURES OF EMERGENCY SURGERY PERFORMANCE FOR PREGNANT WOMEN AND PUERPERAS
Authors: Izimbergenov N. I. , Karimova B. Zh. , Koishibaev A. S. , Izimbergenova G. N. , Imanbaev K. S. , Saduov M. A. , Mukhamedgalieva B. M.
Published: July 2019

The results of treatment of acute surgical diseases are worse in pregnant women, than in ordinary people, because of changes in patient’s organism. However, these patients would be treated the same way as ordinary patient according to conventional standards. The authors launched the special centre for treatment of acute surgical diseases of abdominal cavity for pregnant women and puerperas in order to provide the adequacy of treatment to the changes of patient’s organism. There was suggested a new standard of diagnostics, based on limited term (4-5 hours) with the following diagnostic laparoscopy or laparotomy in obscure cases. The experience of treatment of 171 patients with acute pancreatitis proved the high efficacy of the new strategy and developed standard of diagnostics. The main part of the patients were operated at the first 2-4 hours (105 patients - 61,4%) after hospitalization and 43 (25,1%) patients - within 4-6 hours. The cattaral form (92 patients - 53,8%) and phlegmonous (74 patients - 43,3%) form of the appendix changes were revealed in majority of patients. The gangrenous appendicitis was detected in 5 cases (2%). All the patients recovered. There wasn’t maternal or perinatal mortality.
ROLE OF KINETIC PERFORMANCE OF PSA IN SELECTION OF THE PATIENTS FOR CONDUCTION OF ¹¹C-CHOLINE PET/CT AIMED TO REVEAL LOCAL RECURRENCES OF PROSTATE CANCER
Authors: Rybalov M. A. , De Iong I. Ya. , Breusma A. I. , Al’-Shukri S. Kh. , Borovets S. Yu.
Published: July 2019

Given study was aimed to research a role of kinetic performance of PSA in selection of the patients for conduction ¹¹C-choline PET/CT in order to reveal local recurrences in patient with prostate cancer after radiation therapy (RT) and radical prostatectomy (RP). The study included 185 patients with histologically distinctive prostate cancer and biochemical signs of tumor recurrence after RP (61 patients) or RT (124 patients). All the patients were examined using ¹¹C-choline PET/ CT in order to detect local relapses. Calculation of growth rate of the PSA level and PSA doubling time were made. According to results of ¹¹C-choline PET/CT, recurrences of prostate cancer were detected in 124 out of 185 (65%). There were 22 patients out of 61 (36%) after RP and there were 102 patients out of 124 (82%) after RT. It was stated a correlation between PSA rates, growth rate of PSA level and presence or absence of relapse according to PET/CT results. PSA level and growth rate of PSA were indicated as the most significant predictive signs, which could influence on the selection of the patients for conduction of ¹¹C-choline PET/CT in relation to detection of local recurrence after RT and RP.
EXPERIENCE OF TREATMENT OF NEWBORN CHILDREN WITH GASTROSCHISIS
Authors: Bisaliev B. N. , Tsap N. A.
Published: July 2019

The article presents an analysis of 10-year treatment results of 62 children with gastroschisis. Children were divided into two groups and it depended on the applied surgical treatment. An elimination of congenital eventration using Bianchi method was performed for children of the main group. The operative methods such as siloplasty, Gross operation, alloplasty and primary radical abdominoplasty were performed for children of comparison group. Comparative assessment of efficacy of the treatment methods of gastroschisis showed, that Bianchi method had a number of advantages: an early transition to independent breath and enteral feeding, shortening of hospital stay, decrease of the rate of lethality from 66,6% to 14,2%.
FEATURES OF OTOGENIC INTRACRANIAL COMPLICATIONS AT THE PRESENT STAGE
Authors: Krivopalov A. A. , Yanov Yu. K. , Astashchenko S. V. , Shcherbuk A. Yu. , Artyushkin S. A. , Vakhrushev S. G. , Piskunov I. S. , Piskunov V. S. , Tuzikov N. A.
Published: July 2019

A retrospective analysis of treatment was made in 127 adult patients with acute and chronic otitis media complicated by suppurative-inflammatory pathology of the brain. Purulent meningitis was revealed in 52 (40,9%) of hospitalized patients. Meningoencephalitis was often diagnosed in the cases of acute otitis media (15,4%) and in cases of chronic otitis (22,7%). The otogenic brain abscess was detected in 13,5% of otitis media cases and it was noted to be twice frequent (33,3%) in cases of purulent otitis media. The patients 124 (97,6%) have been operated. An extended mastoidotomy and antromastoidotomy were performed in the acute purulent otitis media. An extended radical operation on the ear was applied in case of chronic otitis media. Performance of craniotomy and complete removal of the abscess using modern systems of neuronavigation showed a higher clinical efficacy as compared with transtemporal approach during sanitizing intervention on the ear including the opening and abscess drainage in surgery of otogenic abscesses of the brain.
ASSESSMENT OF EXPERIMENTAL AND CLINICAL EFFICACY OF IMMOBILIZED FORM OF CHLORHEXIDINE IN TREATMENT OF PURULENT WOUNDS
Authors: Sukovatykh B. S. , Bezhin A. I. , Pankrusheva T. A. , Grigor’Yan A. Yu. , Ivanov A. V. , Zhilyaeva L. V. , Kobzareva E. V. , Andryukhina E. G. , Dubonos A. A.
Published: July 2019

The authors made an analysis of the results of experimental course of wound process on 120 rats of Vistar line and clinical research of 58 patients with purulent wounds, which were treated by ointment of following composition: chlorhexidine bigluconate 0,5-30,0; methyluracil -2,0; polymethylsiloxane polyhydrate -70,0. The animals and people were divided into 2 statistically uniform groups. The control group had a local treatment of wound by the ointment «Levomekol’». The experimental group used the immobilized forms of chlorhexidine. Dynamics of wound process was studied by planimetric, bacteriological and cytological methods of research. Results of planimetric, bacteriological and cytological investigations proved the more expressed positive effect of purulent wound treatment using immobilized form of chlorhexidine bigluconate.
INFLUENCE OF PERMANENT PACING OF THE ATRIA FROM UPPER ANTERIOR AREA OF INTERCARDIAC SEPTA (AREA OF BAKHMAN’S FASCICLES) ON THE PART OF AMOTIVATIONAL VENTRICLE STIMULATION
Authors: Didenko M. V. , Pasenov G. S. , Khubulava G. G.
Published: July 2019

This research includes 74 patients with syndrome of the sinus node asthenia. The application of permanent bilocular pacing was indicated for these patients. An atrial electrode was located in the right atrial auricle in 37 patients and it was in the area of Bakhman’s fascicles in other 37 patients. All the patients had a stimulated atrio-ventricular delay on 250 ms, but sensing delay was shorter on 20 ms. Given data were analyzed after operation in the periods of 6 and 12 months. Cumulative percent of ventricular stimulation was significantly less in the group with electrode in the area of Bakhman’s fascicles (6%) as compared with the group where electrode installed in the right atrial auricle (41%) after 6 months. There were 4% in comparison with 43% after 12 months. The localization of atrial electrode in the area of Bakhman’s fascicles led to reduction of cumulative percent of ventricular stimulation on 35% after 6 months and on 39% after 12 months. Permanent pacing in the area of Bakhman’s fascicles could be an effective mode to decrease the part of amotivational stimulation of the right ventricle.
MR-IMAGING IN DIAGNOSTICS OF FOCAL LIVER LESIONS
Authors: Bagnenko S. S. , Trufanov G. E. , Zheleznyak I. S.
Published: July 2019

The authors determined the efficacy of main methods of MR-imaging and their part in differentiated diagnostics of focal liver lesions. There were examined 256 patients and 414 liver lesions were analyzed. It was shown that the efficacy of conventional research without application of contrast medium was very limited (efficacy of mathematical model 58%). The data obtained during dynamic contrast enchancement (efficacy of the model 67%) were the basis for differentiated diagnostics for majority of nosological forms. The investigation using hepatotropic contrast medium had the greatest possibilities (efficacy of the model 80%). MR-diffusion is the effective procedure for visualization of focal liver lesions, but its possibilities in differentiated diagnostics is limited.
APPLICATION OF LAPAROSCOPIC LIFTING SYSTEMS IN PATIENTS WITH HIGH CARDIORESPIRATORY RISK
Authors: Khitar’Yan A. G. , Miziev I. A. , Provotorov M. E. , Veliev K. S. , Glumov E. E. , Kovalev S. A. , Abramyants M. Kh. , Khubiev S. T.
Published: July 2019

Intra-abdominal hypertension during laparoscopic operations increased the risk of complications from cardiovascular and respiratory systems. An application of laparolifting systems allowed doctors to avoid changes of pneumoperitoneum, although it was associated with technical difficulties in operation performance. The authors used a test in order to determine cardiorespiratory reserve in preoperative period. The reserve was characterized by decrease of stroke volume of the heart against the background of intra-abdominal hypertension. There was noted a reliable increase of complication rate in these patients in case of application of standard laparoscopic operation compared with operation using lifting systems.
ENDOBRONCHIAL PHOTODYNAMIC THERAPY UNDER FLUORESCENCE CONTROL: PHOTODYNAMIC THERANOSTICS
Authors: Akopov A. L. , Rusanov A. A. , Papayan G. V. , Kazakov N. V. , Gerasin A. V.
Published: July 2019

One of the disadvantages of photodynamic therapy is impossibility to specify the method according to biological features of malignant tumor such as a degree of blood supply, accumulation of photosensibilizator in tumorous tissue, proliferative activity and etc. The authors aimed to develop a mode of individualization of endobronchial photodynamic therapy of central non-small cell carcinoma of lung and assessment of method efficacy. The suggested method is based on fluorescent diagnostics of degree of accumulation of photosensibilizator in timorous tissue and the rate of its expenditure in process of performing of photodynamic therapy. There was made a comparison of parameters of methods and results of photodynamic therapy in 2 randomized groups. Each group consisted of 45 patients. The research method was applied in the main group and the standard method was used in the comparison group. It was found that the research method allowed significant reduction of duration of irradiation compared with conventional method (at the average from 690±65sec to 470±45sec, p=0,02), though the treatment results were the same. The suggested method allowed separation of group of patients with absence of fluorescence of timorous tissue. Performance of photodynamic therapy is unreasonable for these patients.
MEDIASTINOSCOPY IN SURGERY OF BENIGN DISEASES OF ESOPHAGUS AND CARDIAC ORIFICE
Authors: Chikinev Yu. V. , Drobyazgin E. A.
Published: July 2019

An article presents the results of application of mediatinoscopy in extirpation of the esophagus and cardiac orifice. The comparative assessment was made in group of patients who underwent the standard surgery. An application of mediastinoscopy for excretion and extirpation of the esophagus allowed doctors to cut down the duration of intervention on 40,15%. The volume of intraoperative loss of blood was reduced on 45,52% and the rate of intraoperative complications decreased on more than 45% compared with standard surgery. There was noted the reduction of the rate of postoperative complications more than 30% and the course of postoperative period was smooth. These factors shortened hospital stay and time the patients should be in resuscitation department.
DIAGNOSTICS AND TREATMENT OF RECURRENT POSTOPERATIVE GOITER
Authors: Zarivchatskiy M. F. , Denisov S. A. , Blinov S. A. , Mugatarov I. N. , Teplykh N. S. , Kolyvanova M. V. , Kravtsova T. Yu.
Published: July 2019

The study developed the system of therapeutic and prophylactic methods in patients with recurrent postoperative goiter. These patients (103) have been accepted and registered in the medical records since 2007. Only 48 patients underwent recurrent operation. The subtotal resection of the thyroid gland was performed on 20 patients and thyroidectomy was carried out in 28 patients. The perioperative visualization of recurrent laryngeal nerves was made in 58,3% cases. Postoperative period was complicated by unilateral recurrent nerve trauma in one patient and transient hypoparathyroidism was noted in two patients. The recurrent operative interventions must be performed in specialized centers and it should be extremely radical operation with visualization of recurrent laryngeal nerves.
POSSIBILITIES OF ULTRASOUND METHOD OF RESEARCH IN EARLY DIAGNOSTICS OF THYROID CARCINOMA
Authors: Shulutko A. M. , Semikov V. I. , Patalova A. P. , Gorbacheva A. V. , Gryaznov S. E. , Mansurova G. T. , Boblak Yu. A.
Published: July 2019

OBJECTIVE. This study evaluated the possibilities of ultrasound in diagnostics of early thyroid carcinoma. MATERIALS AND METHODS. The authors have compared the ultrasound results with data of postoperative histological examination in 106 patients with differentiated thyroid carcinoma. There were 140 patients with nodular proliferating colloid goiter and 42 patients with follicular thyroid adenomas. RESULTS. The individual ultrasound signs of differentiated thyroid tumors with the size of 1cm in diameter were determined. The ultrasound symptom complex of papilliary carcinoma was defined. Ultrasound features of follicular carcinoma were nonspecific. Noncapsulation papillary carcinoma had pathognomonic ultrasound picture. The ultrasound image of follicular and papillary carcinoma would be similar in presence of capsule. CONCLUSIONS. The accurate analysis of ultrasound image gave the possibility of diagnostics of papilliary carcinoma at early stage with high degree of probability.
Endocrine predictors of testicular biopsy efficacy in patients with azoospermia
Authors: Toropov V. A. , Borovets S. Yu. , Al’-Shukri S. Kh. , Gzgzyan A. M. , Belousov V. Ya. , Fedorova I. D.
Published: July 2019

OBJECTIVE. The study identified predictors of endocrine detection of sperm in case of open testicular biopsy in patients with non-obstructive azoospermia. MATERIAL AND METHODS. The research was based on the results of examination and testicular biopsy of 76 patients with secretory azoospermia aged from 20 to 55 years old. The instrumental, laboratory, physical methods of research were carried out for all the patients before performing of the open biopsy for testicular sperm extraction. Hormone levels were determined in blood plasma such as luteinizing hormone, follicle stimulating hormone, prolactin, total and free testosterone, estradiol and sex steroid binding globulin. Patients were divided into two groups. The first group consisted of patients (n =43) whom sperms were found in testicular biopsies. The second group included patients (n = 33) whom sperms weren’t detected. RESULTS. Сonсentration of follicle stimulating hormone in blood plasma was the most significant hormone predictor. It was found that follicle stimulating hormone level between 12 and 16 IU/L indicated to the low probability of sperm presence in testicular biopsies and in case it was less than 17 IU/L the probability was extremely low. There was also established that elevated follicle stimulating hormone levels in patients older than 26 years pointed to the low probability of finding sperm using open testicular sperm extraction. CONCLUSIONS. Increase of luteinizing hormone, follicle stimulating hormone or their correlation in blood plasma indicates to a low probability of finding sperm by open testicular sperm extraction. The concentrations of testosterone, sex steroid binding globulin, prolactin and estradiol in the blood plasma weren’t reliable predictors of finding sperm in testicular biopsies.
Method of formation of pancreatoenteroanastomosis in pancreatoduodenal resection
Authors: Tarasenko S. V. , Natal’Skiy A. A. , Peskov O. D. , Kadykova O. A. , Rakhmaev T. S. , Bogomolov A. Yu.
Published: July 2019

OBJECTIVE. Тhе article considered the various modern techniques of panсreatoenteroanastomosis formation and their results from critical positions. MATERIAL AND METHODS. The authors suggested to apply a new method of panсreatoenteroanastomosis formation in order to decrease the rate of lethality, postoperative complications and traumatic conditions after operation. RESULTS. The developed method of panсreatoenteroanastomosis formation was used in 25 patients with chronic pancreatitis at the period from 2015 to 2016. CONCLUSIONS. The satisfactory results were obtained and that confirmed the efficacy and significance of the method.
Neoadjuvant chemoradiotherapy in combined treatment of patients with rectal cancer
Authors: Maistrenko N. A. , Galkin V. N. , Erygin D. V. , Sazonov A. A.
Published: July 2019

OBJECTIVE. The article analyzed an efficacy and safety of application of neoadjuvant chemoradiotherapy (CRT) in elderly and senile patients with rectal cancer. MATERIAL AND METHODS. An analysis of treatment results was made in 267 patients, who were divided into two groups. The first group (n = 142) underwent combined treatment that included prolonged course of neoadjuvant CRT followed by surgery. The second group of 125 patients underwent surgery without application of CRT. The patients of both groups were subdivided according their age. The subgroup “A” consisted of young and middle age patients. The subgroup “B” included geriatric patients. Comparative analysis was made between the same age subgroups. RESULTS. The age factor didn’t significantly influence on the risk of complications of neoadjuvant CRT and its adverse effects on subsequent outcome of surgery. The application of preoperative CRT in geriatric patients accompanied by less significant growth of recurrence-free survival compared with young patients. CONCLUSIONS. The age factor shouldn’t restrict the application of neoadjuvant CRT in patients with satisfactory general health status and absence of tumor complication process.
Development of management of emergency surgical care for patients with acute traumatic and nontraumatic spinal pathologies in conditions of megapolis
Authors: Dulaev A. K. , Manukovskiy V. A. , Kutyanov D. I. , Bulakhtin Yu. Yu. , Brizhan’ S. L. , Zhelnov P. V.
Published: July 2019

OBJECTIVE. The authors developed the management strategy of emergency care for patients with acute spinal surgical pathology in conditions of megapolis. MATERIAL AND METHODS. A comparative statistical analysis was made in 2627 patients. The patients (n =777) underwent treatment in multicenter hospitals of emergency care of the spine (decentralized system). The other patients (n = 1850) were treated in Municipal Center of Emergency Surgery of the Spine (centralized system). RESULTS. It is appropriate to establish departments of emergency surgery of the spine on the base of separate multicenter hospitals in megapolis. These hospitals should be properly equipped and they should have specially trained doctors and nurses, stable financing, effective management on admission to hospital. CONCLUSIONS. The efficacy of proposed measures allowed authors to recommend them to wide practical application.
Comparative analysis of transabdominal preperitoneal and total extraperitoneal plastic surgeries in inguinal hernia repair
Authors: Savin A. S. , Khokhlov A. V. , Dvoryankin D. V.
Published: July 2019

OBJECTIVE. Comparative analysis of transabdominal preperitoneal (TAPP) and total extraperitoneal (TEP) plastic surgeries was made in case of inguinal hernia repair. MATERIAL AND METHODS. Patients (n =236) underwent surgery at the period from 2012 till 2016. The TAPP was performed in 114 (48,3 %) patients and TEP was carried out in 122 (51,7 %). Clinical analysis of results was made in two groups. RESULTS. The research didn’t show any significant difference in the rate of intra- and postoperative complications and recurrences, but their structure varied. However, length of operation was less in case of one-sided hernia in TAPP group, although it was less in case of two-sided hernia in TEP group. An expression of pain syndrome was reliably lower in TEP group. CONCLUSIONS. Both methods demonstrated similar results and could be applied in treatment of inguinal hernias.
ZENKER-DIVERTICULUM: DIAGNOSTICS AND TREATMENT
Authors: Tulupov A. N. , Sinenchenko G. I. , Safoev M. I. , Nikitin A. V.
Published: July 2019

OBJECTIVE. The study determined an optimal method of surgical treatment of Zenker-diverticulum. MATERIALS AND METHODS. The patients (12 men) were examined using X-ray contrasting of the esophagus and fibroesophagoscopy. The planned diverticulectomy from cervical access was performed on all patients. RESULTS. The treatment was without complications and the patients had favorable outcomes and good long-term results. CONCLUSIONS. The open diverticulectomy using cervical access is the operation of choice.
Reduction of resection volume in patients with non-small cell lung cancer after neoadjuvant chemoand photodynamic therapy
Authors: Akopov A. L. , Chistaykov I. V. , Rusanov A. A. , Urtenova M. A. , Dvoretskiy S. Yu. , Kazakov N. V. , Gerasin A. V. , Gorbunkov S. D. , Agishev A. S. , Il’In A. A. , Romanikhin A. I.
Published: July 2019

OBJECTIVE. The research evaluated efficacy of combined treatment of initially nonresectable and inoperable cases of non-small cell lung cancer. The treatment consisted of preoperative endobronchial and intraoperave photodynamic therapies. MATERIAL AND METHODS. The prospective investigation included patients with central non-small cell lung cancer. These cases were initially considered as nonresectable (the trachea was involved in tumor) or inoperable (functional intolerance of pneumoectomy/ bilobectomy). Neoadjuvant chemotherapy (2-6 courses) and endobronchial photodynamic therapy (PDT) were conducted for these patients in preoperative period. PDT of resection edge was carried out during the operation and it was straight away after specimen removal and ipsilateral lymphodissection. RESULTS. The research was made on 38 patients. Lung resections underwent 30 (79 %) patients. Surgeries included 20 pneumoectomies and 10 lobectomies. Bronchial resection was performed by crossing an initially affected zone. It was noted that 5-year survival consisted of 68 %. CONCLUSIONS. Photodynamic therapy was important in combination with chemotherapy and surgical treatment of central non-small cell lung cancer. These measures allowed doctors to decrease the resection volume in part of inoperable patients or patients with initially nonresectable tumors.
Pre-biopsy modelling of condition of germinogenic epithelium in azoospermia using endocrine and genetic predictors
Authors: Borovets S. Yu. , Toropov V. A. , Al'-Shukri S. Kh.
Published: July 2019

OBJECTIVE. The study revealed clinical, endocrine and genetical predictors of safety of spermatogenic epithelium in patients with nonobstructive azoospermia. MATERIAL AND METHODS. The open testicular biopsy was performed in 38 patients with secretory azoospermia. The wide range of instrumental, laboratory studies were conducted before biopsy. RESULTS. Two prognostic models were developed by taking into account the revealed predictors of damage of germinogenic epithelium. CONCLUSIONS. The age, concentration of follicle-stimulating hormone, presence or absence of microdeletion AZFc are independent prognostic predictors of germinal epithelium condition.
Recurrent intussusception in children
Authors: Podkamenev V. V. , Pikalo I. A. , Sharapov I. S. , Petrov E. M. , Potemkin M. I. , Latypov V. Kh. , Mikhailov N. I. , Moroz S. V.
Published: July 2019

OBJECTIVE. The study considered the rate and clinical features of recurrent intussusception in children. MATERIAL AND METHODS. Retrospective analysis was made in all patients with intussusception at the period from 2006 to 2016. RESULTS. There were observed 45 cases of intussusception recurrence in 39 (14,5 %) children out of 268. Relapse of intussusception was three times more frequent in boys compared with girls (29 (74,4 %) vs 10 (25,5 %) and it was four times more frequent in children older than one year. The majority of patients (28 (71,8 %) have been admitted to hospital at the first 12 hours since onset of disease. Recurrence of intussusception was more frequent after conservative disinvagination compared with surgery (17,8 % vs 2,5 %; p = 0,026). Pathological formation of the intestine (Meckel’s diverticulum, doubling of the small intestine) were detected in 3 (7,7 %) out of 39 patients with relapse intussusception compared with 3 (1,3 %) out of 229 patients without recurrence (p = 0,05). Conservative treatment was conducted in 23 (59 %) patients and 16 (41,0 %) patients underwent surgery. There weren’t noted severe complications of lethal outcomes. CONCLUSIONS. The authors observed the tendency of frequent recurrence of intussusception in children, especially after conservative treatment.
Features of vertebral arteries pathology at trauma
Authors: Shchedrenok V. V. , Zakhmatova T. V. , Moguchaya O. V.
Published: July 2019

OBJECTIVE. The authors compared results of changes in clinical and radial studies of vertebral arteries in case of trauma of cervical spine. MATERIAL AND METHODS. An analysis of data of complex examination and treatment was made in 157 victims aged 38,5 ± 1,5 years old. RESULTS. Pathology of vertebral arteries was detected in 68,8 % cases. The main ultrasound syndromes were deformations of speed with local hemodynamic significance, compression with systemic deficiency of blood flow, irritative effects, extravasal changes on the level of V-3 segment, thrombosis and dissection. CONCLUSIONS. The development of hemodynamically significant local effects on the vertebral artery depended on degree of stenosis and cross-section area of its canal.
New method for predicting endogenous intoxication in patients with peritonitis
Authors: Vlasov A. P. , Zaitsev P. P. , Vlasov P. A. , Polozova E. I. , Bolotskikh V. A. , Vlasova T. I. , Vasil’Ev V. V.
Published: July 2019

OBJECTIVE. The authors developed the integral criterion of prediction of endogenous intoxication in acute peritonitis based on evaluation of homeostatic disorders in blood plasma. MATERIAL AND METHODS. The patients (42) with peritonitis of moderate severity aged from 20 to 59 years old were examined. Calculation of prediction index of endogeneous intoxication using the proposed formula was made. RESULTS. Given clinical and laboratory data showed that the severity of peritonitis was caused by endogeneous intoxication, which was associated with intensification of lipid peroxidation process. The proposed index of prediction of endogenous intoxication allowed doctors to perform an accurate and adequate prevention of the possibility of endogeneous intoxication progress in acute pancreatitis. CONCLUSIONS. There was demonstrated the high efficacy of new integral criterion of prediction of endogeneous intoxication in acute peritonitis.
A X-ray Excitable Vibrational AIE System Based on Platinum (II) Salts
Authors: zhao zheng , Wang Zaiyu , Tavakoli Javad , Peng Chen , Xiong Yu , Tang Youhong , Lam Jacky W. Y. , Tang Ben Zhong
Published: July 2019

The current work reported an inorganic salt based aggregation-induced emission system which can be excited by X-ray. The underlying mechanism has been systematically studied.
Cysteine-To-Lysine Transfer Antibody Fragment Conjugation
Authors: Forte Nafsika , Benni Irene , Karu Kersti , Chudasama Vijay , Baker James R.
Published: July 2019

The modification of lysine residues with acylating agents has represented a ubiquitous approach to the construction of antibody conjugates, with the resulting amide bonds being robustly stable and clinically validated. However, the conjugates are highly heterogeneous, due to the presence of numerous lysines on the surface of the protein, and greater control of the sites of conjugation are keenly sought. Here we present a novel approach to achieve the targeted modification of lysines distal to an antibody fragment’s binding site, using a disulfide bond as a temporary ‘hook’ to deliver the acylating agent. This cysteine-to-lysine transfer (CLT) methodology offers greatly improved homogeneity of lysine conjugates, whilst retaining the advantages offered by the formation of amide linkages.
Experimental Strategies for Avoiding Saturation Effects in ESI-MS
Authors: Wei Alan , Joshi Anuj , Chen Yuxuan , McIndoe J Scott
Published: July 2019

All instruments with detectors are prone to saturation effects at high concentration, and mass spectrometers are no exception. The very high sensitivity of mass spectrometry makes the onset of saturation occur at lower concentrations than other methods, and in cases where the analyte of interest is very reactive, concentrations at which saturation can be problematic may be necessary in order to ensure decomposition is mitigated. Indications that saturation is occurring are provided, and some data processing strategies are outlined, followed by a range of detuning strategies that may be employed to reduce saturation effects in the context of electrospray ionization mass spectrometry (ESI-MS), including lowering voltages on detector or capillary, increasing cone gas flow rates, or adjusting the probe position. A combination of strategies generally allows researchers to make the best possible compromises when studying compounds at relatively high concentration.
Proteome-Wide Survey Reveals Norbornene Is Complementary to Dimedone and Related Nucleophilic Probes for Cysteine Sulfenic Acid
Authors: Alcock Lisa , Langini Maike , Stühler Kai , Remke Marc , Perkins Michael , Bernardes Gonçalo , Chalker Justin
Published: July 2019

Detection of cysteine sulfenic acid in live cells is critical in advancing our understanding of cysteine redox chemistry and its biological function. Accordingly, there is a need to develop sulfenic acid-specific chemical probes with distinct reaction mechanisms to facilitate proteome-wide detection of this important posttranslational modification. Herein, we report the first whole-cell proteomics analysis using a norbornene probe to detect cysteine sulfenic acid in live HeLa cells. Comparison of the enriched proteins to those identified using dimedone and other C-nucleophilic probes revealed a complementary reactivity profile. Remarkably, 148 new members of the sulfenome were identified. These discoveries highlight how subtle differences in chemical reactivity of both the probes and cysteine residues influence detection. Overall, this study expands our understanding of protein oxidation at cysteine and reveals new proteins to consider for future studies of cysteine oxidation, redox regulation and signaling, and the biochemistry of oxidative stress.
PRDM9 forms a trimer by interactions within the zinc finger array
Authors: Schwarz Theresa , Striedner Yasmin , Horner Andreas , Haase Karin , Kemptner Jasmin , Zeppezauer Nicole , Hermann Philipp , Tiemann-Boege Irene
Published: July 2019

PRDM9 is a trans-acting factor directing meiotic recombination to specific DNA-binding sites by its zinc finger (ZnF) array. It was suggested that PRDM9 is a multimer; however, we do not know the stoichiometry or the components inducing PRDM9 multimerization. In this work, we used in vitro binding studies and characterized with electrophoretic mobility shift assays, mass spectrometry, and fluorescence correlation spectroscopy the stoichiometry of the PRDM9 multimer of two different murine PRDM9 alleles carrying different tags and domains produced with different expression systems. Based on the migration distance of the PRDM9–DNA complex, we show that PRDM9 forms a trimer. Moreover, this stoichiometry is adapted already by the free, soluble protein with little exchange between protein monomers. The variable ZnF array of PRDM9 is sufficient for multimerization, and at least five ZnFs form already a functional trimer. Finally, we also show that only one ZnF array within the PRDM9 oligomer binds to the DNA, whereas the remaining two ZnF arrays likely maintain the trimer by ZnF–ZnF interactions.
Digging into the Downward Trend in Consumer Inflation Expectations
Authors: Verbrugge Randal J. , Binder Carola Conces
Published: July 2019

Since mid-2014, the long-run inflation expectations of consumers have been declining. We analyze University of Michigan Surveys of Consumers microdata and find that a decline in uncertainty about future inflation is a modest part of the story over this period—but it represents the entire story when considering changes in expectations since 2012.
Biomarkers of Temporomandibular Disorders
Authors: Dominica Dian , Naliani Silvia , Lelyana Shelly , Sandra Ferry
Published: July 2019

Temporomandibular disorder is a disorder that includes masticatory muscles or temporomandibular joints, unbalanced joint function or both. The disorders can disturb daily activity, cause by pain. The therapy consuming time and cost. Early detection of temporomandibular disorder is needed, as a prevention of more severe disorders. Increased cortisol can be found in myofacial pain and is not found in internal dearagement or osteoarthritis. Biomarkers of interleukin and monocyte chemoattractant proteins are only found in osteoarthritis. The use of biomarkers can be useful in detecting temporomandibular disorders. Biomarkers can be measured from blood, serum and saliva. Cortisol, dopamine and TAC are potential biomarkers in the temporomandibular disorder.
Aligning resources and conditions to achieve an optimal business solution for operating in an Economic Development Zone
Authors: Bettendorf Hugh
Published: July 2019

Operating a business in an Economic Development Zone can offer benefits allowing a business owner to reduce its operating expenses and increasing the competitive advantage.
Locating a New Collegiate Entrepreneurship Program, a framework for a University Campus
Authors: H Carter Douglas
Published: July 2019

Entrepreneurship has emerged over the last three decades as arguable the most potent economic force the world has ever experienced. This economic expansion has paralleled rapid growth in the field of entrepreneurship education. Recent developments in curricula and programs devoted to entrepreneurship, new venture creation and corporate innovation have been remarkable. The number of colleges and universities that offer courses related to entrepreneurship has grown from a handful 35 years ago to over 3000 today. In the midst of this expansion lies the challenge of establishing and sustaining entrepreneurship programs in universities across the globe. (Morris, Kuratko & Cornwall, 2013) The literature review will help inform us of the current status of entrepreneurship programs on university campuses and provide us with some indication of any changes in the idea of where to place a new program.
The Equine Industry: Competing Beliefs, Change and Conflict
Authors: Lord Robyn
Published: July 2019

Fifty million years ago, the equine is chronicled in the early days of Eohippus, the earliest known horse to man. In the 1400s, Cortez and Christopher Columbus transported the first domestic horses to the Americas. Ancient times supported the use of horses in times of war where the industry began utilizing the horse as a vehicle. Today, the equine industry is strongly steeped in traditions and cultural beliefs that prove consistent to the early rituals. However, within the last few decades, the equine industry started to see a radical new change to the age-old tradition of horsemanship. This new sub-culture is called natural horsemanship. This movement, as it was called in the beginning, challenged tradition and millions of years of beliefs. Why did some adopt and others not? The focus on this study is to define the industry, creating a solid picture of how the change began, why the change was necessary in the eyes of some, and what is the current state of the industry as it stands. In this research, the equine industry will serve as an industry model revealing beliefs and cultural frameworks that can serve as a blueprint for other industries who may be experiencing changes to an embedded culture way of doing business.
With proposed change comes conflict. The human stress factor, conflict and personal dedication necessary to change decades of tradition is a daunting task. Long-standing belief systems are usually embedded in tradition and society’s acceptance of the status quo. As humans, we initially will resist as change is difficult and takes effort with responsibility. The literature review will provide solid data supporting this industry adaptation, and how it has affected aspects of the industry. Data will also provide the existence of opposing forces: natural versus traditional and what that means for those on each side. While this offers innovative opportunities for some, it has provided deeper traction in regulatory bodies, traditional organizations, and professional treatment of the equine. The equine industry analysis will demonstrate a unique glimpse into an industry at the forefront of possible change, whereas for centuries none had occurred.
Are U.S. Millennials Really Disengaged at Work? A Review of the Academic and Practitioner Literature
Authors: Clark Danielle
Published: July 2019

This is a generational workplace engagement article focused on millennials. The article introduces a variety of academic and practitioner information and research relating to millennial disengagement in the workplace. Concepts covered include employee engagement and disengagement, generational differences and specifically millennial engagement and disengagement. The goal of the article is to review the evidence thus far addressing the question, “Are U.S. millennials working in a corporate environment more disengaged than other generations?”
So You Want to be a Change Agent
Authors: Wyatt Susan
Published: July 2019

This paper analyzes a range of theories of change agency for the purpose of exploring possible ways for individuals to practice social change that are inspired by Jungian thought. The methodology for this paper is a narration of varioustheories of social and organizational change. The study uses variations of the story of the Rainmaker, told by C. G. Jung, to explore the connection between individual and social change. The conclusion considers the contribution thatJungian theory can make to the resolution of the tensions that are inevitably engendered by the thoughtful facilitation of social change
Hemingway’s Francis Macomber in “God’s Country”
Authors: Fike Matthew A.
Published: July 2019

In 1925−26, C. G. Jung’s Bugishu Psychological Expedition journeyed through Kenya, the setting of Ernest Hemingway’s “The Short Happy Life of Francis Macomber.” Although the two authors went to Africa for vastly different reasons,Jung’s insights into the personal and collective unconscious, along with the discoveries he made while there, provide a lens through which to complement previous Freudian and Lacanian studies of the story. Francis, a puer aeternus andintroverted thinker, overcomes his initial mother complex by doing shadow work with his hunting guide, Robert Wilson. As the story progresses, Francis makes the unconscious more conscious through dreaming and then connects with thearchaic/primordial man buried deeply below his modern civilized persona. The essay thus resolves two long-standing critical cruxes: the title character makes genuine psychological progress; and his wife, whether she shoots at the buffalo orat him, targets primordial masculine strength.
Generational Attention: Remembering How to Be a People
Authors: Dunlap Peter T.
Published: July 2019

In the aftermath of World War I C. G. Jung responded to the destruction wrought by humankind by imagining humanity as a single, semi-conscious being. Jung imagines a naturalistic God capable of helping us remember how to be a people by using an awareness of all of human history to guide the species’ decision-making. As a psychologist I use Jung’s image to cultivate this “generational attention” in progressive political groups, particularly helping them cultivate the “public emotional intelligence” necessary to bind themselves to one another as a human community. Today the Jungian community can contribute to the articulation of a uniquely Jungian political psychology by following this image and by integrating a more differentiated feeling function in our organizations as we go.