bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells
Authors: Yao Yanhua , Zhang Nannan , Liu Xiao , Dai Qiaofeng , Liu Haiying , Wei Zhongchao , Tie Shaolong , Li Yinyin , Fan Haihua , Lan Sheng
Published: October 2018

In this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelles of A375 cells. After analyzing the angle and space between the nanorods in clusters, a series of numerical simulations were performed and the results show that the plasmon resonance coupling between the gold nanorods can lead to a field enhancement of up to 60 times. Such high energy localization causes the temperature around the nanorods to rise rapidly and induce cell death. In this treatment, a laser as low as 9.3 mW was used to irradiate a single cell for 20 s and the cell died two h later. The cell death time can also be controlled by changing the power of laser which is focused on the cells. The advantage of this therapy is low laser treatment power, short treatment time, and small treatment range. As a result, the damage of the normal tissue by the photothermal effect can be greatly avoided.
Exploring the Role of Nanoparticles in Enhancing Mechanical Properties of Hydrogel Nanocomposites
Authors: Zaragoza Josergio , Fukuoka Scott , Kraus Marcus , Thomin James , Asuri Prashanth
Published: October 2018

Over the past few decades, research studies have established that the mechanical properties of hydrogels can be largely impacted by the addition of nanoparticles. However, the exact mechanisms behind such enhancements are not yet fully understood. To further explore the role of nanoparticles on the enhanced mechanical properties of hydrogel nanocomposites, we used chemically crosslinked polyacrylamide hydrogels incorporating silica nanoparticles as the model system. Rheological measurements indicate that nanoparticle-mediated increases in hydrogel elastic modulus can exceed the maximum modulus that can be obtained through purely chemical crosslinking. Moreover, the data reveal that nanoparticle, monomer, and chemical crosslinker concentrations can all play an important role on the nanoparticle mediated-enhancements in mechanical properties. These results also demonstrate a strong role for pseudo crosslinking facilitated by polymer–particle interactions on the observed enhancements in elastic moduli. Taken together, our work delves into the role of nanoparticles on enhancing hydrogel properties, which is vital to the development of hydrogel nanocomposites with a wide range of specific mechanical properties.
Micronutrient Status in Sri Lanka: A Review
Authors: Abeywickrama Hansani Madushika , Koyama Yu , Uchiyama Mieko , Shimizu Utako , Iwasa Yuka , Yamada Etsuko , Ohashi Kazuki , Mitobe Yuta
Published: October 2018

Micronutrients include vitamins, minerals and, trace elements that are required in minute quantities but play a vital role in normal human growth, development and physiological functioning. Micronutrient deficiencies, also known as hidden hunger, are a global issue, with particularly high prevalence rates in developing countries. Currently, Sri Lanka is experiencing the double burden of over- and undernutrition. This review describes the micronutrient status of Sri Lanka based on results of national surveys and related articles published from 2000. The available data suggest a higher prevalence of iron, zinc, calcium, folate, and vitamin A deficiencies. The prevalence of iodine deficiency has declined gradually following the implementation of a universal salt iodization program. Iron deficiency is the most common cause of anemia and low red blood cell indices. Females are more vulnerable to micronutrient deficiencies than males. The coexistence of multiple micronutrient deficiencies and concurrent macro- and micronutrient deficiencies is common. Studies have shown an association between micronutrient deficiencies and different demographic, socioeconomic, and dietary factors. Therefore, there is a need for comprehensive studies, nutritional policies, and nationwide intervention programs in Sri Lanka to improve the micronutrient status of the population.
Adherence of Malaysian Adults’ Energy and Macronutrient Intakes to National Recommendations: A Review and Meta-Analysis
Authors: Shahar Suzana , Jan Bin Jan Mohamed Hamid , De los Reyes Francisco , Amarra Maria Sofia
Published: October 2018

The present study examined the best available evidence regarding energy and macronutrient intake during adulthood (age 19 to 59 years) in Malaysia and assessed whether intakes adhere to national recommendations, in order to develop recommendations for dietary improvement based on population consumption patterns. A literature review and meta-analysis evaluated intake based on the following characteristics, using information from food balance sheets, national surveys, and individual studies: (1) levels of intake, (2) proportion of the population whose diets adhere to/exceed/fail to meet Malaysian Recommended Nutrient Intake (RNI) levels, and (3) sources of macronutrients observed in these studies. Food balance data suggested high levels of available energy, animal source protein, vegetable fat, and refined carbohydrates. Twenty studies (five nationwide, 15 individual) indicated that Malaysian adults generally met or exceeded recommendations for fat and protein, but were inconsistent with respect to energy and carbohydrates. Information on dietary sources was limited. Due to methodological limitations, insufficient evidence exists regarding energy and macronutrient intakes of Malaysian adults. Improved dietary assessment methods (including use of biomarkers), better data analysis, and updated food composition data, will provide more reliable information on which to base policy decisions and recommendations for improvement.
Prospective Association between Total and Specific Dietary Polyphenol Intakes and Cardiovascular Disease Risk in the Nutrinet-Santé French Cohort
Authors: Adriouch Solia , Lampuré Aurélie , Nechba Anouar , Baudry Julia , Assmann Karen , Kesse-Guyot Emmanuelle , Hercberg Serge , Scalbert Augustin , Touvier Mathilde , Fezeu Léopold K.
Published: October 2018

Background: Epidemiological and experimental evidence support a protective effect of dietary polyphenols on chronic diseases, but high quality longitudinal data are needed, including details on categories of polyphenols. Our objective was to investigate the prospective association between total and individual classes and subclasses of dietary polyphenols and the risk of major cardiovascular disease in the NutriNet-Santé cohort. Methods: A total of 84,158 participants, who completed at least three 24 h dietary records, were included between May 2009 and June 2017. Individual polyphenols intakes were obtained by matching food consumption data from the 24 h dietary records with the Phenol-Explorer polyphenol composition database. Multivariable Cox proportional hazards models were used to characterize the associations between dietary polyphenols and the incidence of cardiovascular diseases, comparing tertile T3 vs. T1 of classes and subclasses of polyphenols. Results: Over a median of 4.9 years of follow-up, 602 major cardiovascular events were diagnosed. Intakes of anthocyanins, catechins, and flavonols were strongly inversely associated with cardiovascular disease risk (anthocyanins: Hazard Ratio (HR)for a 1-point increment of 10 mg/day = 0.98 (0.96–0.99, p = 0.03, HRT3vs.T1 = 0.66 (0.52–0.83), ptrend = 0.0003; catechins: HRfor a 1-point increment of 10 mg/day = 0.98 (0.96–0.99), p = 0.02, HRT3vs.T1 = 0.74 (0.60–0.91), ptrend = 0.004; flavonols: HRfor a 1-point increment of 10 mg/day = 0.94 (0.90–0.99), p = 0.02, HRT3vs.T1 = 0.75 (0.61–0.94), ptrend = 0.006). Intakes of dihydrochalcones, proanthocyaninidins, dihydroflavonols, hydroxybenzoic acids, and stilbenes were also associated with a decrease (13%, 19%, 24%, 24%, and 27%, respectively) in cardiovascular disease risk, when comparing tertile T3 to T1. Conclusions: Higher intakes of polyphenols, especially of anthocyanins, catechins, and flavonols, were associated with a statistically significant decreased cardiovascular disease risk.
Chungkookjang with High Contents of Poly-γ-Glutamic Acid Improves Insulin Sensitizing Activity in Adipocytes and Neuronal Cells
Authors: Jeong Seong-Yeop , Jeong Do Yeon , Kim Da Sol , Park Sunmin
Published: October 2018

We hypothesized that soybeans fermented with Bacillus spp. for 48 h (chungkookjang) would be rich in poly-γ-glutamate (γ-PGA) and would have greater efficacy for improving insulin sensitivity and insulin secretion in 3T3-L1 adipocytes, min6 cells, and PC12 neuronal cells. We screened 20 different strains of B. subtillus and B. amyloliquefaciens spp. for γ-polyglutamate (PGA) production and their anti-diabetic and anti-dementia activities in cell-based studies. Chungkookjang made with two B. amyloliquefaciens spp. (BA730 and BA731) were selected to increase the isoflavonoid and γ-PGA. Insulin-stimulated glucose uptake was higher in 3T3-L1 adipocytes given both chungkookjang extracts than in the cells given vehicle (control). The ethanol extract of BA731 (BA731-E) increased the uptake the most. Triglyceride accumulation decreased in BA731-E and BA731-W and the accumulation increased in BA730-W and BA730-E. The mRNA expression of fatty acid synthetase and acetyl CoA carboxylase was much lower in BA731-E and BA731-W and it was higher in BA730-W than the control. BA730-E and BA730-W also increased peroxisome proliferator-activated receptor (PPAR)-γ activity. Glucose-stimulated insulin secretion increased with the high dosage of BA730-W and BA730-E in insulinoma cells, compared to the control. Insulin contents and cell survival in high glucose media were higher in cells with both BA731-E and BA730-E. Triglyceride deposition and TNF-α mRNA expression were lower in BA731 than the control. The high-dosage treatment of BA730-E and BA731-E increased differentiated neuronal cell survival after treating amyloid-β(25-35) compared to the control. Brain-derived neurotrophic factor and ciliary neurotrophic factor, indices of neuronal cell proliferation, were higher in BA730 and BA731 than in the control. Tau expression was also reduced in BA731 more than the control and it was a similar level of the normal-control. In conclusion, BA730 increased PPAR-γ activity and BA731 enhanced insulin sensitivity in the brain and periphery. BA730 and BA731 prevented and alleviated the symptoms of type 2 diabetes and Alzheimer’s disease with different pathways.
Development and Evaluation of a Water Soluble Fluorometholone Eye Drop Formulation Employing Polymeric Micelle
Authors: Noh Gyubin , Keum Taekwang , Seo Jo-Eun , Choi Jaewoong , Rakesh Bastola , Shrawani Lamichhane , Park Byoungduck , Choi Young Wook , Lee Sangkil
Published: October 2018

Low aqueous solubility of drug causes difficulties in preparation and inconvenience of administration. Polymeric micelles of fluorometholone (FML) using solid dispersion technique were prepared to develop an eye drop formulation with enhanced water solubility. Solid dispersions of FML were prepared at various FML:Soluplus® w/w ratios using solvent evaporation method. A physical mixture was also prepared. Physicochemical characterization was performed with various methods. Ex vivo porcine corneal permeation of polymeric micelle, physical mixture, and commercial product were compared. FML solid dispersion (1:15) showed the highest solubility, which was c.a. 169.6- and 15.3-fold higher than that of pure FML and physical mixture. Characterization showed that the crystalline form of FML changed to amorphous state and polymeric micelles were formed in round micelle. Flucon®, a commercial product of FML, showed significantly large particle size and high poly dispersity index. In contrast, FML polymeric micelle showed submicron size with uniform size distribution. Ex vivo porcine corneal permeation study showed that permeation by polymeric micelles was significantly higher than that by the commercial product and physical mixture. In addition, confocal laser scanning microscopic analysis supported the enhanced porcine corneal tissue permeation property of polymeric micelle. In conclusion, polymeric micelle prepared with solid dispersion using Soluplus® can be a potential nanomedicine for ocular delivery of poorly water-soluble FML.
Cationic Moieties in Polystyrene Gels Swollen with d-Limonene Improved Transdermal Delivery System
Authors: Charoensumran Preeyarad , Ajiro Hiroharu
Published: October 2018

d-limonene, a terpene and natural compound, has been found to be an excellent penetration enhancer for transdermal drug delivery (TDD). It hence has been incorporated within various transdermal formulations. Herein, we report the application of polystyrene gel swollen with d-limonene and its derivatives for TDD. Poly(styrene-co-divinylbenzene) (PS gel), poly(styrene-co-divinylbenzene-co-4-vinylpyridine) (PS-4VP) gel and poly(styrene-co-divinylbenzene-co-(vinylbenzyl) trimethylammonium chloride) (PS-VBAC gel) were employed as chemical gels to improve the stability of the TDD substrates. The drug permeation properties from the PS gels swollen in limonene were examined, regarding the effect of its network density as well as their rheological properties. The lowest density of the network showed the highest steady flux of the permeation at 43.7 ± 0.3 μg/cm2. FT-IR spectra were confirmed for PS-4VP and PS-VBAC, bearing cationic moieties and they could control the release of ibuprofen by the electrostatic interaction at the interface of organogel and skin. The steady state flux of skin permeation got low values from 55.2 ± 0.8 to 11.6 ± 2.0 μg/cm2, when the cationic moieties were increased. Moreover, the chemical network of PS gel swollen in limonene showed high mechanical stability illustrated by elastic modulus (G’) of about 98 kPa for 10% cross-linked PS gel. The developed PS gels swollen in limonene show highly promising results, suggesting their possible application in TDD.
Graphene-Based Thermal Interface Materials: An Application-Oriented Perspective on Architecture Design
Authors: Lv Le , Dai Wen , Li Aijun , Lin Cheng-Te
Published: October 2018

With the increasing power density of electrical and electronic devices, there has been an urgent demand for the development of thermal interface materials (TIMs) with high through-plane thermal conductivity for handling the issue of thermal management. Graphene exhibited significant potential for the development of TIMs, due to its ultra-high intrinsic thermal conductivity. In this perspective, we introduce three state-of-the-art graphene-based TIMs, including dispersed graphene/polymers, graphene framework/polymers and inorganic graphene-based monoliths. The advantages and limitations of them were discussed from an application point of view. In addition, possible strategies and future research directions in the development of high-performance graphene-based TIMs are also discussed.
Injectable and Gellable Chitosan Formulations Filled with Cellulose Nanofibers for Intervertebral Disc Tissue Engineering
Authors: Doench Ingo , Torres-Ramos Maria , Montembault Alexandra , Nunes de Oliveira Paula , Halimi Celia , Viguier Eric , Heux Laurent , Siadous Robin , Thiré Rossana , Osorio-Madrazo Anayancy
Published: October 2018

The development of non-cellularized injectable suspensions of viscous chitosan (CHI) solutions (1.7–3.3% (w/w)), filled with cellulose nanofibers (CNF) (0.02–0.6% (w/w)) of the type nanofibrillated cellulose, was proposed for viscosupplementation of the intervertebral disc nucleus pulposus tissue. The achievement of CNF/CHI formulations which can gel in situ at the disc injection site constitutes a minimally-invasive approach to restore damaged/degenerated discs. We studied physico-chemical aspects of the sol and gel states of the CNF/CHI formulations, including the rheological behavior in relation to injectability (sol state) and fiber mechanical reinforcement (gel state). CNF-CHI interactions could be evidenced by a double flow behavior due to the relaxation of the CHI polymer chains and those interacting with the CNFs. At high shear rates resembling the injection conditions with needles commonly used in surgical treatments, both the reference CHI viscous solutions and those filled with CNFs exhibited similar rheological behavior. The neutralization of the flowing and weakly acidic CNF/CHI suspensions yielded composite hydrogels in which the nanofibers reinforced the CHI matrix. We performed evaluations in relation to the biomedical application, such as the effect of the intradiscal injection of the CNF/CHI formulation in pig and rabbit spine models on disc biomechanics. We showed that the injectable formulations became hydrogels in situ after intradiscal gelation, due to CHI neutralization occurring in contact with the body fluids. No leakage of the injectate through the injection canal was observed and the gelled formulation restored the disc height and loss of mechanical properties, which is commonly related to disc degeneration.
Polyhydroxyalkanoate (PHA) Polymer Accumulation and pha Gene Expression in Phenazine (phz-) and Pyrrolnitrin (prn-) Defective Mutants of Pseudomonas chlororaphis PA23
Authors: Sharma Parveen K. , Munir Riffat I. , Plouffe Jocelyn , Shah Nidhi , De Kievit Teresa , Levin David B.
Published: October 2018

Pseudomonas chlororaphis PA23 was isolated from the rhizosphere of soybeans and identified as a biocontrol bacterium against Sclerotinia sclerotiorum, a fungal plant pathogen. This bacterium produces a number of secondary metabolites, including phenazine-1-carboxylic acid, 2-hydroxyphenazine, pyrrolnitrin (PRN), hydrogen cyanide, proteases, lipases and siderophores. It also synthesizes and accumulates polyhydroxyalkanoate (PHA) polymers as carbon and energy storage compounds under nutrient-limited conditions. Pseudomonads like P. chlororaphis metabolize glucose via the Entner-Doudoroff and Pentose Phosphate pathways, which provide precursors for phenazine production. Mutants defective in phenazine (PHZ; PA23-63), PRN (PA23-8), or both (PA23-63-1) accumulated higher concentrations of PHAs than the wild-type strain (PA23) when cultured in Ramsay’s Minimal Medium with glucose or octanoic acid as the carbon source. Expression levels of six pha genes, phaC1, phaZ, phaC2, phaD, phaF, and phaI, were compared with wild type PA23 by quantitative real time polymerase chain reaction (qPCR). The qPCR studies indicated that there was no change in levels of transcription of the PHA synthase genes phaC1 and phaC2 in the phz- (PA23-63) and phz- prn- (PA23-63-1) mutants in glucose medium. There was a significant increase in expression of phaC2 in octanoate medium. Transcription of phaD, phaF and phaI increased significantly in the phz- prn- (PA23-63-1) mutant. Mutations in regulatory genes like gacS, rpoS, and relA/spoT, which affect PHZ and PRN production, also resulted in altered gene expression. The expression of phaC1, phaC2, phaF, and phaI genes was down-regulated significantly in gacS and rpoS mutants. Thus, it appears that PHZ, PRN, and PHA production is regulated by common mechanisms. Higher PHA production in the phz- (PA23-63), prn- (PA23-8), and phz- prn- (PA23-63-1) mutants in octanoic medium could be correlated with higher expression of phaC2. Further, the greater PHA production observed in the phz- and prn- mutants was not due to increased transcription of PHA synthase genes in glucose medium, but due to more accessibility of carbon substrates and reducing power, which were otherwise used for the synthesis of PHZ and PRN.
Candlelight for Our Country’s Right Name: A Confucian Interpretation of South Korea’s Candlelight Revolution
Authors: Kim Sungmoon
Published: October 2018

The candlelight protest that took place in South Korea from October 2016 to March 2017 was a landmark political event, not least because it ultimately led to the impeachment of President Park Geun-hye. Arguably, its more historically important meaning lies in the fact that it marks the first nation-wide political struggle since the June Uprising of 1987, where civil society won an unequivocal victory over a regime that was found to be corrupt, unjust, and undemocratic, making it the most orderly, civil, and peaceful political revolution in modern Korean history. Despite a plethora of literature investigating the cause of what is now called “the Candlelight Revolution” and its implications for Korean democracy, less attention has been paid to the cultural motivation and moral discourse that galvanized Korean civil society. This paper captures the Korean civil society which resulted in the Candlelight Revolution in terms of Confucian democratic civil society, distinct from both liberal pluralist civil society and Confucian meritocratic civil society, and argues that Confucian democratic civil society can provide a useful conceptual tool by which to not only philosophically construct a vision of civil society that is culturally relevant and politically practicable but also to critically evaluate the politics of civil society in the East Asian context.
Whence Orthodox Jewish Feminism? Cognitive Dissonance and Religious Change in the United States
Authors: Shain Michelle
Published: October 2018

A large literature on feminist theology and philosophy of religion has explored the various ways in which feminism has reshaped religious thought and practice within different faith traditions. This study uses Festinger’s (1965) cognitive dissonance theory and the 2017 Nishma Research Survey of American Modern Orthodox Jews to examine the effect of tension between feminism and Orthodox Judaism on lay men and women. For 14% of Modern Orthodox Jews, issues related to women or women’s roles are what cause them “the most pain or unhappiness” as Orthodox Jews. The paper examines the sociodemographic characteristics associated with this response and tests whether those who experience this cognitive dissonance are more likely to (1) advocate for changes in the role of women within Orthodox Judaism and/or (2) experience religious doubt. The analysis reveals that these individuals overwhelmingly take a feminist stance on issues related to women’s roles in Orthodox Judaism, and they also manifest more religious doubt. The paper discusses the dual potential of cognitive dissonance to either spur changes in women’s religious roles in traditional religious communities and/or threaten the demographic vitality of those communities.
Alpha Beta Risk and Stock Returns—A Decomposition Analysis of Idiosyncratic Volatility with Conditional Models
Authors: Fu Chengbo
Published: October 2018

The variance of stock returns is decomposed based on a conditional Fama–French three-factor model instead of its unconditional counterpart. Using time-varying alpha and betas in this model, it is evident that four additional risk terms must be considered. They include the variance of alpha, the variance of the interaction between the time-varying component of beta and factors, and two covariance terms. These additional risk terms are components that are included in the idiosyncratic risk estimate using an unconditional model. By investigating the relation between the risk terms and stock returns, we find that only the variance of the time-varying alpha is negatively associated with stock returns. Further tests show that stock returns are not affected by the variance of time-varying beta. These results are consistent with the findings in the literature identifying return predictability from time-varying alpha rather than betas.
Quantitative Assessment for Detection and Monitoring of Coastline Dynamics with Temporal RADARSAT Images
Authors: Pradhan Biswajeet , Rizeei Hossein Mojaddadi , Abdulle Abdinur
Published: October 2018

This study aims to detect coastline changes using temporal synthetic aperture radar (SAR) images for the state of Kelantan, Malaysia. Two active images, namely, RADARSAT-1 captured in 2003 and RADARSAT-2 captured in 2014, were used to monitor such changes. We applied noise removal and edge detection filtering on RADARSAT images for preprocessing to remove salt and pepper distortion. Different segmentation analyses were also applied to the filtered images. Firstly, multiresolution segmentation, maximum spectral difference and chessboard segmentation were performed to separate land pixels from ocean ones. Next, the Taguchi method was used to optimise segmentation parameters. Subsequently, a support vector machine algorithm was applied on the optimised segments to classify shorelines with an accuracy of 98% for both temporal images. Results were validated using a thematic map from the Department of Survey and Mapping of Malaysia. The change detection showed an average difference in the shoreline of 12.5 m between 2003 and 2014. The methods developed in this study demonstrate the ability of active SAR sensors to map and detect shoreline changes, especially during low or high tides in tropical regions where passive sensor imagery is often masked by clouds.
Erratum: Hu, P.B., et al. toward Reconstructing 3D Buildings from ALS Data Based on Gestalt Laws. Remote Sens. 2018, 10, 1127
Authors: Hu Pingbo , Yang Bisheng , Dong Zhen , Yuan Pengfei , Huang Ronggang , Fan Hongchao , Sun Xuan
Published: October 2018

The authors wish to make a correction to their paper [...]
A 250 m Direct Time-of-Flight Ranging System Based on a Synthesis of Sub-Ranging Images and a Vertical Avalanche Photo-Diodes (VAPD) CMOS Image Sensor
Authors: Hirose Yutaka , Koyama Shinzo , Ishii Motonori , Saitou Shigeru , Takemoto Masato , Nose Yugo , Inoue Akito , Sakata Yusuke , Sugiura Yuki , Kabe Tatsuya , Usuda Manabu , Kasuga Shigetaka , Mori Mitsuyoshi , Odagawa Akihiro , Tanaka Tsuyoshi
Published: October 2018

We have developed a direct time-of-flight (TOF) 250 m ranging Complementary Metal Oxide Semiconductor (CMOS) image sensor (CIS) based on a 688 × 384 pixels array of vertical avalanche photodiodes (VAPD). Each pixel of the CIS comprises VAPD with a standard four transistor pixel circuit equipped with an analogue capacitor to accumulate or count avalanche pulses. High power near infrared (NIR) short (<50 ns) and repetitive (6 kHz) laser pulses are illuminated through a diffusing optics. By globally gating the VAPD, each pulse is counted in the in-pixel counter enabling extraction of sub-photon level signal. Depth map imaging with a 10 cm lateral resolution is realized from 1 m to 250 m range by synthesizing subranges images of photon counts. Advantages and limitation of an in-pixel circuit are described. The developed CIS is expected to supersede insufficient resolution of the conventional light detection and ranging (LiDAR) systems and the short range of indirect CIS TOF.
Speckle Noise Suppression in SAR Images Using a Three-Step Algorithm
Authors: Yu Ze , Wang Wenqi , Li Chunsheng , Liu Wei , Yang Jian
Published: October 2018

Speckle noise can reduce the image quality of synthetic aperture radar (SAR) and complicate image interpretation. This study proposes a novel three-step approach based on the conventional probabilistic patch-based (PPB) algorithm to minimize the impact of bright structures on speckle suppression. The first step improves the calculation accuracy of the weight by pre-processing speckle noise with a linear minimum mean-square error filter and reassessing similarity between pixels. In the second step, an iterative method is developed to avoid interfering with bright structures and acquires a more accurate homogeneous factor by adaptively changing the size of the search window. In the final step, the spreading and blurring of bright structures is corrected using a modified bias-reduction technique. Experimental results demonstrate the proposed algorithm has improved performance for both speckle suppression and preservation of edges and textures, evaluated by indicators including the equivalent number of looks, the edge preservation index, the mean, and standard deviation of ratio images.
Remote Welfare Monitoring of Rodents Using Thermal Imaging
Authors: Barbosa Pereira Carina , Kunczik Janosch , Zieglowski Leonie , Tolba René , Abdelrahman Ahmed , Zechner Dietmar , Vollmar Brigitte , Janssen Heike , Thum Thomas , Czaplik Michael
Published: October 2018

Animal research has always played a crucial role in various medical and scientific breakthroughs. They offer, inter alia, insights into diseases mechanisms, genetic predisposition to a disease, and drug therapy. However, the use of animals for medical research is a cause of major controversies and debates in modern science. To warrant high bioethical standards, new directives have been being adopted to replace animal research whenever possible, to reduce the number of animals, and to refine the procedures to minimize stress and pain. Here, we present two new approaches, based on thermal imaging (a remote and passive technology), to assess respiratory rate (RR) as well as exploratory behavior and general activity in rodents. In animal research, these parameters are gold standards for welfare assessment. The approaches were validated in a study conducted with both rats and mice. To test the feasibility of our algorithm to estimate RR, thermal videos from anesthetized rodents were acquired. The capability of the second approach to monitor activity was tested with videos of Open Field tests. Regarding RR, a high agreement between thermal imaging and gold standard (electrocardiography-derived RR) was achieved. The mean relative error averaged 0.50 ± 0.15 breaths/min and 4.55 ± 2.94 breaths/min for rats and mice, respectively. The second approach was capable of monitoring and tracking the activity of the rodents very well. This paper demonstrates that thermal imaging is a promising and relevant alternative for monitoring of RR and activity in rodents, thus contributing to the remote assessment of animal welfare.
Video-Based Person Re-Identification by an End-To-End Learning Architecture with Hybrid Deep Appearance-Temporal Feature
Authors: Sun Rui , Huang Qiheng , Xia Miaomiao , Zhang Jun
Published: October 2018

Video-based person re-identification is an important task with the challenges of lighting variation, low-resolution images, background clutter, occlusion, and human appearance similarity in the multi-camera visual sensor networks. In this paper, we propose a video-based person re-identification method called the end-to-end learning architecture with hybrid deep appearance-temporal feature. It can learn the appearance features of pivotal frames, the temporal features, and the independent distance metric of different features. This architecture consists of two-stream deep feature structure and two Siamese networks. For the first-stream structure, we propose the Two-branch Appearance Feature (TAF) sub-structure to obtain the appearance information of persons, and used one of the two Siamese networks to learn the similarity of appearance features of a pairwise person. To utilize the temporal information, we designed the second-stream structure that consisting of the Optical flow Temporal Feature (OTF) sub-structure and another Siamese network, to learn the person’s temporal features and the distances of pairwise features. In addition, we select the pivotal frames of video as inputs to the Inception-V3 network on the Two-branch Appearance Feature sub-structure, and employ the salience-learning fusion layer to fuse the learned global and local appearance features. Extensive experimental results on the PRID2011, iLIDS-VID, and Motion Analysis and Re-identification Set (MARS) datasets showed that the respective proposed architectures reached 79%, 59% and 72% at Rank-1 and had advantages over state-of-the-art algorithms. Meanwhile, it also improved the feature representation ability of persons.
Volatilities of Book Income and Taxable Income and Their Risk Relevance
Authors: Kim Joonhyun
Published: October 2018

This study investigates the volatility of book income and taxable income, and their relevance to stock returns variability. Book income is recognized under the financial accounting principle whereas taxable income is determined on the basis of legal right. Thus, the two types of earnings can provide different sets of information to investors. Particularly related to the role of earnings as a risk measure, this study shows that book income is more volatile than taxable income, which indicates that taxable income is relatively more consistent and predictable. Further, the volatility of book income is strongly positively related to stock return variability while the taxable income volatility is insignificantly associated with the stock returns volatility. Additional analysis shows that the earnings volatility is more closely linked to the systematic risk of stock prices than the idiosyncratic risk. In conclusion, this study suggests that book income and taxable income is mutually different in terms of earnings variability and its relevance to firm risk. The findings also indicate that those two sets of earnings information are complementary to each other and provides investors with useful information to assess underlying firm risk.
Preliminary Scale of Reference Values for Evaluating Reactive Strength Index-Modified in Male and Female NCAA Division I Athletes
Authors: Sole Christopher J. , Suchomel Timothy J. , Stone Michael H.
Published: October 2018

The purpose of this analysis was to construct a preliminary scale of reference values for reactive strength index-modified (RSImod). Countermovement jump data from 151 National Collegiate Athletic Association (NCAA) Division I collegiate athletes (male n = 76; female n = 75) were analyzed. Using percentiles, scales for both male and female samples were constructed. For further analysis, athletes were separated into four performance groups based on RSImod and comparisons of jump height (JH), and time to takeoff (TTT) were performed. RSImod values ranged from 0.208 to 0.704 and 0.135 to 0.553 in males and females, respectively. Males had greater RSImod (p < 0.001, d = 1.15) and JH (p < 0.001, d = 1.41) as compared to females. No statistically significant difference was observed for TTT between males and females (p = 0.909, d = 0.02). Only JH was found to be statistically different between all performance groups. For TTT no statistical differences were observed when comparing the top two and middle two groups for males and top two, bottom two, and middle two groups for females. Similarities in TTT between sexes and across performance groups suggests JH is a primary factor contributing to differences in RSImod. The results of this analysis provide practitioners with additional insight as well as a scale of reference values for evaluating RSImod scores in collegiate athletes.
Sustainable Management and Successful Application of Constructed Wetlands: A Critical Review
Authors: Gorgoglione Angela , Torretta Vincenzo
Published: October 2018

Constructed wetlands (CWs) are affordable and reliable green technologies for the treatment of various types of wastewater. Compared to conventional treatment systems, CWs offer an environmental-friendly approach, are low cost, have fewer operational and maintenance requirements, and have a high potential for being applied in developing countries; particularly in small rural communities. However, the sustainable management and successful application of these systems remain a challenge. Therefore, after briefly giving basic information on wetlands and summarizing the classification and use of current CWs, this study aims to provide sustainable solutions for the performance and applications of CWs. To accomplish this objective, design and management parameters of CWs, including macrophyte species, media types, water level, hydraulic retention time (HRT), and hydraulic loading rate (HLR), are discussed. The current study collects and presents results of more than 120 case studies from around the world. This work provides a tool for researchers and decision-makers for using CWs to treat wastewater in a particular area. This study presents an aid for informed analysis, decision-making, and communication.
Roadway Lighting Retrofit: Environmental and Economic Impact of Greenhouse Gases Footprint Reduction
Authors: Sȩdziwy Adam , Basiura Artur , Wojnicki Igor
Published: October 2018

Roadway lighting retrofit is a process continuously developed in urban environments due to both installation aging and technical upgrades. The spectacular example is replacing the high intensity discharge (HID) lamps, usually high pressure sodium (HPS) ones, with the sources based on light-emitting diodes (LED). The main focus in the related research was put on energy efficiency of installations and corresponding financial benefits. In this work, we extend those considerations analyzing how lighting optimization impacts greenhouse gas (GHG) emission reduction and what are the resultant financial benefits expressed in terms of emission allowances prices. Our goal is twofold: (i) obtaining a quantitative assessment of how a GHG footprint depends on a technological scope of modernization of a city HPS-based lighting system; and (ii) showing that the costs of such a modernization can be decreased by up to 10% thanks to a lowered CO 2 emission volume. Moreover, we identify retrofit patterns yielding the most substantial environmental impact.
Development of the Financial Sector and Growth of Microfinance Institutions: The Moderating Effect of Economic Growth
Authors: Sainz-Fernandez Isabel , Torre-Olmo Begoña , López-Gutiérrez Carlos , Sanfilippo-Azofra Sergio
Published: October 2018

This article analyzes the moderating effect the degree of economic growth has on the relationship between the development of the financial system and the microfinance industry activity. The hypotheses proposed establish that the influence of the development of the financial system on the activity of the microfinance sector will be different depending on the level of economic growth. The estimates were made using the System-GMM methodology for panel data, which allows controlling the unobservable heterogeneity and the problems of endogeneity. We find that the degree of economic growth affects the relationship between the financial sector development and microfinance activity. Under negative economic growth conditions, the development of the financial sector has a negative impact on the activity of the microfinance sector, but when economic growth is high, the development of the financial sector positively influences the activity of the microfinance sector.
Carbon Quantum Dots Encapsulated Molecularly Imprinted Fluorescence Quenching Particles for Sensitive Detection of Zearalenone in Corn Sample
Authors: Shao Manyu , Yao Ming , Saeger Sarah De , Yan Liping , Song Suquan
Published: October 2018

An eco-friendly and efficient one-step approach for the synthesis of carbon quantum dots (CDs) that encapsulated molecularly imprinted fluorescence quenching particles (MIFQP) and their application for the determination of zearalenone (ZEA) in a cereal sample are described in this study. CDs with high luminescence were first synthesized, and then encapsulated in the silica-based matrix through a non-hydrolytic sol-gel process. The resulting ZEA-imprinted particles exhibited not only an excellent specific molecular recognition of ZEA, but also good photostability and obvious template binding-induced fluorescence quenching. Under the optimized conditions, the fluorescence intensity of MIFQP was inversely proportional to the concentration of ZEA. By validation, the detection range of these fluorescence quenching materials for ZEA was between 0.02 and 1.0 mg L−1, and the detection limit was 0.02 mg L−1 (S/N = 3). Finally, the MIFQP sensor was successfully applied for ZEA determination in corn with recoveries from 78% to 105% and the relative standard deviation (RSD %) was lower than 20%, which suggests its potential in actual applications.
Heterologous Replicase from Cucumoviruses can Replicate Viral RNAs, but is Defective in Transcribing Subgenomic RNA4A or Facilitating Viral Movement
Authors: Gao Shuangyu , Lu Jinda , Cheng Xiaodong , Gu Zhouhang , Liao Qiansheng , Du Zhiyou
Published: October 2018

Interspecific exchange of RNA1 or RNA2 between the cucumoviruses cucumber mosaic virus (CMV) and tomato aspermy virus (TAV) was reported to be non-viable in plants previously. Here we investigated viability of the reassortants between CMV and TAV in Nicotiana benthamiana plants by Agrobacterium-mediated viral inoculation. The reassortants were composed of CMV RNA1 and TAV RNA2 plus RNA3 replicated in the inoculated leaves, while they were defective in viral systemic movement at the early stage of infection. Interestingly, the reassortant containing TAV RNA1 and CMV RNA2 and RNA3 infected plants systemically, but produced RNA4A (the RNA2 subgenome) at an undetectable level. The defect in production of RNA4A was due to the 1a protein encoded by TAV RNA1, and partially restored by replacing the C-terminus (helicase domain) in TAV 1a with that of CMV 1a. Collectively, exchange of the replicase components between CMV and TAV was acceptable for viral replication, but was defective in either directing transcription of subgenomic RNA4A or facilitating viral long-distance movement. Our finding may shed some light on evolution of subgenomic RNA4A in the family Bromoviridae.
An Integrated Modeling Approach to Study the Surface Water-Groundwater Interactions and Influence of Temporal Damping Effects on the Hydrological Cycle in the Miho Catchment in South Korea
Authors: Joo Jaewon , Tian Yong , Zheng Chunmiao , Zheng Yi , Sun Zan , Zhang Aijing , Chang Hyungjoon
Published: October 2018

Integrated surface water–groundwater (SW–GW) models could be used to assess the impacts of climate change or variability on the hydrological cycle. However, the damping effects of the hydrological system have rarely been explored via integrated SW–GW modeling. This paper presents an integrated modeling study in a typical humid area, the Miho catchment in Korea, using an integrated model called Groundwater and Surface-water FLOW (GSFLOW). The major findings of this study are as follows: (1) The simulated results from 2005 to 2014 indicate that the temporal variability in the streamflow, stream-groundwater interactions and groundwater recharge are dominated by the precipitation, while the temporal variability in the evapotranspiration (ET) is controlled by the energy conditions; (2) Damping effects can affect the hydrological cycle across different temporal and spatial scales. At the catchment scale, the soil zone and aquifer play a dominant role in damping the precipitation on monthly and annual time scales, respectively; (3) Variability in the capacity to buffer earlier precipitation is found at small spatial scales, such as streams, and larger spatial scales, such as the whole catchment. This variability could affect the water balance at larger spatial scales and affect the hydrography recession at smaller spatial scales.
Effect of Aeration Modes and COD/N Ratios on Organic Matter and Nitrogen Removal in Horizontal Subsurface Flow Constructed Wetland Mesocosms
Authors: Chen Xin , Zhu Hui , Xu Yingying , Shutes Brian , Yan Baixing , Zhou Qingwei
Published: October 2018

A series of mesocosm-scale horizontal subsurface flow constructed wetlands (HSSF-CWs) were established. In Experiment 1, four artificial aeration (AA) modes, including pre-aeration at 24 h before the input of influent water (PA), aeration at 6 h (6AA) and 12 h (12AA) after the input of influent water and non-aeration (NA), were tested to obtain an optimal aeration mode for chemical oxygen demand (CODCr) and nitrogen removal. The results showed that aeration after the input of influent water could improve the removal efficiencies of CODCr and ammonia-nitrogen (NH4⁺-N), but lead to an accumulation of nitrate-nitrogen (NO3−-N). The above observation demonstrated that a single aeration cannot create an ideal alternation of aerobic and anaerobic conditions for simultaneous nitrification and denitrification. Therefore, HSSF-CWs with intermittent aeration (IA), after the input of influent water and NA were established to evaluate the combined effects of IA and influent COD/N ratios on pollutant removal in Experiment 2. The HSSF-CW with IA exhibited a better performance in CODCr and nitrogen removal compared to HSSF-CW with NA. The highest removal percentages of CODCr (90.1%), NH4+-N (99.8%) and total nitrogen (TN, 99.5%) were achieved at a COD/N ratio of 9.3 in HSSF-CW with IA.
Assessment of SWAT Model Performance in Simulating Daily Streamflow under Rainfall Data Scarcity in Pacific Island Watersheds
Authors: Leta Olkeba Tolessa , El-Kadi Aly I. , Dulai Henrietta , Ghazal Kariem A.
Published: October 2018

Evaluating the performance of watershed models is essential for a reliable assessment of water resources, particularly in Pacific island watersheds, where modeling efforts are challenging due to their unique features. Such watersheds are characterized by low water residence time, highly permeable volcanic rock outcrops, high topographic and rainfall spatial variability, and lack of hydrological data. The Soil and Water Assessment Tool (SWAT) model was used for hydrological modeling of the Nuuanu area watershed (NAW) and Heeia watershed on the Island of Oahu (Hawaii). The NAW, which had well-distributed rainfall gauging stations within the watershed, was used for comparison with the Heeia watershed that lacked recoded rainfall data within the watershed. For the latter watershed, daily rain gauge data from the neighboring watersheds and spatially interpolated 250 m resolution rainfall data were used. The objectives were to critically evaluate the performance of SWAT under rain gauge data scarce conditions for small-scale watersheds that experience high rainfall spatial variability over short distances and to determine if spatially interpolated gridded rainfall data can be used as a remedy in such conditions. The model performance was evaluated by using the Nash–Sutcliffe efficiency (NSE), the percent bias (PBIAS), and the coefficient of determination (R2), including model prediction uncertainty at 95% confidence interval (95PCI). Overall, the daily observed streamflow hydrographs were well-represented by SWAT when well-distributed rain gauge data were used for NAW, yielding NSE and R2 values of > 0.5 and bracketing > 70% of observed streamflows at 95PCI. However, the model showed an overall low performance (NSE and R2 ≤ 0.5) for the Heeia watershed compared to the NAW’s results. Although the model showed low performance for Heeia, the gridded rainfall data generally outperformed the rain gauge data that were used from outside of the watershed. Thus, it was concluded that finer resolution gridded rainfall data can be used as a surrogate for watersheds that lack recorded rainfall data in small-scale Pacific island watersheds.