bluuebunny/crossref_metadata_2025 huggingface dataset:
Initial Benchmarking of the Quality of Medical Care in Childhood‐Onset Systemic Lupus Erythematosus
Authors: Mina Rina , Harris Julia G. , Klein‐Gitelman Marisa S. , Appenzeller Simone , Centeville Maraisa , Eskra Diane , Huggins Jennifer L. , Johnson Anne L. , Khubchandani Raju , Khandekar Prachi , Lee Jiha , Liu Hai Mei , Pendl Joshua D. , Silva Clovis A. , Silva Marco F. , Zaal Ahmad I. , DeWitt Esi Morgan , Ardoin Stacy P. , Brunner Hermine I.
Published: July 2015

Objective

To assess the quality of medical care in childhood‐onset systemic lupus erythematosus (SLE) at tertiary pediatric rheumatology centers as measured by observance of SLE quality indicators (SLE‐QIs).

Methods

International consensus has been achieved for childhood‐onset SLE‐QIs capturing medical care provision in 9 domains: diagnostic testing, education of cardiovascular (CV) risk and lifestyles, lupus nephritis (LN), medication management, bone health, ophthalmologic surveillance, transition, pregnancy, and vaccination. Using medical record information, the level of performance of these childhood‐onset SLE‐QIs was assessed in childhood‐onset SLE populations treated at 4 tertiary pediatric rheumatology centers in the US, 2 in Brazil, and 1 center in India.

Results

A total of 483 childhood‐onset SLE patients were assessed. Care for the 310 US patients differed markedly for childhood‐onset SLE‐QIs addressing LN, bone health, vaccinations, education on CV risk, and transition planning. Performance of safety blood testing for medications was high at all centers. Despite often similar performance on the childhood‐onset SLE‐QI, access to kidney biopsies was lower in Brazil than in the US. Irrespective of the country of practice, larger centers tended to meet the childhood‐onset SLE‐QIs more often than smaller centers.

Conclusion

The childhood‐onset SLE‐QIs, evidence‐based minimum standards of medical care, are not consistently met in the US or some other countries outside the US. This has the potential to contribute to suboptimal childhood‐onset SLE outcomes.
Canaries in the coal mine: Personal and professional impact of undergoing whole genome sequencing on medical professionals
Authors: Zierhut Heather , McCarthy Veach Patricia , LeRoy Bonnie
Published: July 2015

Public interest in personal whole genome sequencing is increasing. The technology is publicly available and is being used as an educational tool in higher education. Empirical evidence regarding its utility is vital. The goals of this study were to characterize the process of whole genome sequencing in a population of medical and basic science professionals undergoing whole genome sequencing as a part of an educational symposium. Thirty‐eight individuals completed one or more surveys from the time of informed consent for whole genome sequencing to 3 months post‐symposium. The four surveys assessed demographics, decision‐making, communication, decision regret, and personal and professional impact. The most prevalent motivation to participate was professional enhancement, followed by curiosity about the technology, and personal health benefits. The most important initial impact concerned medical implications. Over time, however, impact on professional development was greater than on personal health. Anticipated reactions to receiving whole genome sequencing results generally matched participants' actual reactions and decision regret remained low over time. Benefits and risks of whole genome sequencing included medically actionable results and misunderstanding by healthcare providers. Whole genome sequencing generally had a positive impact professionally and personally on participants. Further education of providers and the public about whole genome sequencing and psychosocial support is warranted. © 2015 Wiley Periodicals, Inc.
Hydroxoiridium/Chiral Diene Complexes as Effective Catalysts for Asymmetric Annulation of α‐Oxo‐ and Iminocarboxamides with 1,3‐Dienes
Authors: Hatano Miyuki , Nishimura Takahiro
Published: July 2015

The asymmetric [3+2] annulation of α‐oxo‐ and α‐iminocarboxamides with 1,3‐dienes catalyzed by hydroxoiridium/chiral diene complexes was realized, giving high yields of the corresponding γ‐lactams with high enantioselectivity.
Synthesis, characterization, metal sorption, and biological activity of poly(N‐heterocylic acrylamide)
Authors: Al‐Fulaij Othman A. , Elassar Abdel‐Zaher A. , El‐asmy Ahmed F.
Published: July 2015

N‐heterocyclic acrylamide monomers were prepared and then transferred to the corresponding polymers to be used as an efficient chelating agent. Polymers reacted with metal nitrate salts (Cu2+, Pb2+,Mg2+, Cd2+, Ni2+, Co2+,Fe2+) at 150°C to give metal‐polymer complexes. The selectivity of the metal ions using prepared polymers from an aqueous mixture containing different metal ion sreflected that the polymer having thiazolyl moiety more selective than that containing imidazolyl or pyridinyl moieties. Ion selectivity of poly[N‐(benzo[d]thiazol‐2‐yl)acrylamide] showed higher selectivity to many ions e.g. Fe3+, Pb2+, Cd2+, Ni2+, and Cu2+. While, that of poly[N‐(pyridin‐4‐yl)acrylamide] is found to be high selective to Fe3+and Cu2+only. Energy dispersive spectroscopy measurements, morphology of the polymers and their metallopolymer complexes, thermal analysis and antimicrobial activity were studied. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2015,132, 42712.
A 1,1‐Carboboration Route to Bora‐Nazarov Systems
Authors: Ge Fang , Türkyilmaz Fatma , Daniliuc Constantin G. , Siedow Melanie , Eckert Hellmut , Kehr Gerald , Erker Gerhard
Published: July 2015

Hydroboration of the conjugated enynes 1 a and 1 b with Piers’ borane [HB(C6F5)2] gave the respective dienylboranes trans‐2 c and trans‐2 d. Their photolysis resulted in the formation of the dihydroborole products 3 c and 3 d. Both were converted to their pyridine adducts 5 c and 5 d, respectively. Compounds 3 c and 5 c,d were characterized by X‐ray diffraction. The reaction of the bis(enynyl)boranes 6 a and 6 b with B(C6F5)3 resulted in the formation of the dihydroboroles 7 a and 7 b, respectively. This reaction is thought to proceed by 1,1‐carboboration of one of the enynyl substituents at boron to generate the dienylborane intermediates 8 a/8 b, followed by thermally induced bora‐Nazarov ring‐closure and subsequent stabilizing 1,2‐pentafluorophenyl group migration from boron to carbon. Compound 7 a was characterized by X‐ray diffraction and solid‐state 11B NMR spectroscopy.
Discovery of a new blue quasar: SDSS J022218.03–062511.1
Authors: Fix M. B. , Smith J. A. , Tucker D. L. , Wester W. , Annis J.
Published: July 2015

We report the discovery of a bright blue quasar: SDSS J022218.03–062511.1. This object was discovered spectroscopically while searching for hot white dwarfs that may be used as calibration sources for large sky surveys such as the Dark Energy Survey or the Large Synoptic Survey Telescope project. We present the calibrated spectrum, spectral line shifts and report a redshift of z = 0.521±0.0015 and a rest‐frame g‐band luminosity of 8.71×1011 L⊙. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The Gaia spectrophotometric standard stars survey: II. Instrumental effects of six ground‐based observing campaigns
Authors: Altavilla G. , Marinoni S. , Pancino E. , Galleti S. , Ragaini S. , Bellazzini M. , Cocozza G. , Bragaglia A. , Carrasco J. M. , Castro A. , Di Fabrizio L. , Federici L. , Figueras F. , Gebran M. , Jordi C. , Masana E. , Schuster W. , Valentini G. , Voss H.
Published: July 2015

The Gaia SpectroPhotometric Standard Stars (SPSS) survey started in 2006, was awarded almost 450 observing nights and accumulated almost 100000 raw data frames with both photometric and spectroscopic observations. Such large observational effort requires careful, homogeneous, and automatic data reduction and quality control procedures. In this paper, we quantitatively evaluate instrumental effects that might have a significant (i.e., ≥1 %) impact on the Gaia SPSS flux calibration. The measurements involve six different instruments, monitored over the eight years of observations dedicated to the Gaia flux standards campaigns: DOLORES@TNG in La Palma, EFOSC2@NTT and ROSS@REM in La Silla, CAFOS@2.2m in Calar Alto, BFOSC@Cassini in Loiano, and LaRuca@1.5m in San Pedro Mártir. We examine and quantitatively evaluate the following effects: CCD linearity and shutter times, calibration frames stability, lamp flexures, second order contamination, light polarization, and fringing. We present methods to correct for the relevant effects which can be applied to a wide range of observational projects at similar instruments. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A review of East Asian reports of aurorae and comets circa AD 775
Authors: Chapman J. , Neuhäuser D.L. , Neuhäuser R. , Csikszentmihalyi M.
Published: July 2015

Given that a strong 14C variation in AD 775 has recently been suggested to be due to the largest solar flare ever recorded in history, it is relevant to investigate whether celestial events observed around that time may have been aurorae, possibly even very strong aurorae, or otherwise related to the 14C variation (e.g. a suggested comet impact with Earth's atmosphere). We critically review several celestial observations from AD 757 to the end of the 770s, most of which were previously considered to be true, and in some cases, strong aurorae; we discuss in detail the East Asian records and their wording. We conclude that probably none among the events after AD 770 was actually an aurora, including the event in AD 776 Jan, which was misdated for AD 774 or 775; the observed white qi phenomenon that happened above the moon in the south‐east was most probably a halo effect near the full Moon – too late in any case to be related to the 14C variation in AD 774/5. There is another report of a similar (or identical) white qi phenomenon above the moon, reported just before a comet observation and dated to AD 776 Jan; the reported comet observed by the Chinese was misdated to AD 776, but actually sighted in AD 767. Our critical review of East Asian reports of aurorae circa AD 775 shows some very likely true Chinese auroral displays observed and reported for AD 762; there were also several events prior to AD 771 that may have been aurorae but are questionable. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Engineering a novel biosynthetic pathway in Escherichia coli for production of renewable ethylene glycol
Authors: Pereira Brian , Zhang Haoran , De Mey Marjan , Lim Chin Giaw , Li Zheng‐Jun , Stephanopoulos Gregory
Published: July 2015

Ethylene glycol (EG) is an important commodity chemical with broad industrial applications. It is presently produced from petroleum or natural gas feedstocks in processes requiring consumption of significant quantities of non‐renewable resources. Here, we report a novel pathway for biosynthesis of EG from the renewable sugar glucose in metabolically engineered Escherichia coli. Serine‐to‐EG conversion was first achieved through a pathway comprising serine decarboxylase, ethanolamine oxidase, and glycolaldehyde reductase. Serine provision in E. coli was then enhanced by overexpression of the serine‐biosynthesis pathway. The integration of these two parts into the complete EG‐biosynthesis pathway in E. coli allowed for production of 4.1 g/L EG at a cumulative yield of 0.14 g‐EG/g‐glucose, establishing a foundation for a promising biotechnology. Biotechnol. Bioeng. 2016;113: 376–383. © 2015 Wiley Periodicals, Inc.
Discriminative Measurement and Pharmacokinetic Evaluation of Choline Alphoscerate against Endogenous Choline in Human
Authors: Park Suck‐Yong , Choi Sung‐Up , Lee Kyoung‐Hae , Yang Jong‐Beom , Cho Seong‐Wan , Ro Jieun , Kim Hyeongmin , Khadka Prakash , Lee Jaehwi , Cho Cheong‐Weon
Published: July 2015

This study aimed at the evaluation of plasma level profiles of choline produced after the oral administration of choline alphoscerate (CA). For this purpose, a high‐performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) analytical method was developed and validated. Baseline correction technique was employed to monitor the CA‐related choline in plasma by subtracting background levels of choline from total choline levels measured after the drug administration. Choline was well separated in the plasma matrix under the analytical conditions employed for HPLC/MS/MS and the analytical method developed for the monitoring of choline in plasma was well validated. The endogenous choline levels in plasma under fasting condition were measured to be 7.78 ± 1.74 µmol/L for test period 1 and 7.88 ± 1.78 µmol/L for test period 2, respectively, and were considerably increased after consumption of meals. The corrected choline levels in plasma produced only by the oral administration of CA could be evaluated by subtracting the background levels of choline monitored before the drug was administered. The pharmacokinetic parameters estimated for test and control formulations were quite similar based on the comparison of C
max, AUC12h
, and T
max, indicating that these are biologically equivalent dosage forms. The results of our study consequently suggest that the baseline correction method in evaluating plasma concentration profiles of endogenous substances is useful.
Clinical evaluation of the shape of the suprascapular notch—an ultrasonographic and computed tomography comparative study: Application to shoulder pain syndromes
Authors: Polguj Michał , Synder Marek , Kwapisz Adam , Stefańczyk Katarzyna , Grzelak Piotr , Podgórski Michał , Topol Mirosław
Published: July 2015

The most common site of suprascapular nerve compression and injury is the suprascapular notch. The aim of this study was to assess the sensitivity and specificity of sonography in determining the type of suprascapular notch (SSN). Thirty randomized patients (60 upper extremities) underwent USG examination of the shoulder area. The results were further compared with three‐dimensional reconstructions of the scapulae obtained through CT examination to place the SSNs within a fivefold classification. For identification of type I, the sensitivity was 73.3% and the specificity 97.8%. For identification of type III, the values was 96.9% and 85.7%, respectively. Type II was not found in USG examination. Discrimination between type IV and V was not possible. The mean distance between the line connecting the edges of the SSN and the skin was 38 mm in right‐handed patients and 34 mm in ambidextrous subjects. Ultrasonographic examination of the SSN is characterized by high specificity for type I, and high sensitivity for type III SSN. Discrimination between type IV and V of the SSN is not recommended based on sonographic evaluation. Clin. Anat. 28:774–779, 2015. © 2015 Wiley Periodicals, Inc.
Improved Performance of VOx‐Coated Li‐Rich NMC Electrodes
Authors: Laszczynski Nina , von Zamory Jan , Kalhoff Julian , Loeffler Nicholas , Chakravadhanula Venkata Sai Kiran , Passerini Stefano
Published: July 2015

A VOx coating of Li1.2Mn0.56Ni0.16Co0.08O2, made through a low‐temperature annealing process (350 °C), results in the formation of a protecting layer, which enables electrodes to be prepared with an aqueous binder, offering a significantly improved electrochemical performance. The comparison with uncoated electrodes demonstrates the significantly improved performance of VOx‐coated Li1.2Mn0.56Ni0.16Co0.08O2, which substantially outperforms the uncoated material by 30 mAh g−1 at moderate rates. The VOx coating is found to prevent the contact of Li1.2Mn0.56Ni0.16Co0.08O2 with water from the aqueous‐binder processing, preventing leaching of metal cations. Upon cell operation, the coating delays the transformation of the active layer material into the spinel phase, occurring at low voltages, thus delaying its typical capacity fade upon cycling. Finally, the coating contributes to the overall material capacity, while ensuring the lithium deintercalation and intercalation processes.
Single‐Walled Carbon Nanotubes/Au–Mesoporous Silica Janus Nanoparticles as Building Blocks for the Preparation of a Bienzyme Biosensor
Authors: Boujakhrout Abderrahmane , Sánchez Enrique , Díez Paula , Sánchez Alfredo , Martínez‐Ruiz Paloma , Parrado Concepción , Pingarrón José M. , Villalonga Reynaldo
Published: July 2015

Gold–mesoporous silica Janus nanoparticles were prepared through a masking strategy and further employed as building blocks for the preparation of bienzyme biosensors through toposelective immobilization of the corresponding enzymes. The system was evaluated by immobilizing glucose oxidase and horseradish peroxidase on the Au and mesoporous silica faces, respectively. The anisotropic nanoparticles were deposited on glassy carbon electrodes coated with single‐walled carbon nanotubes in order to construct an amperometric biosensor for glucose detection. The enzymatic electrode showed excellent electroanalytical performance with a fast response in about 6 s, a linear range of 490 nm–600 μm, a high sensitivity of 4.3 mA M−1 , and a low detection limit of 360 nm for glucose. This biosensor was successfully employed to determine the content of this monosaccharide in commercial soft drink samples.
Intramolecular Redox‐Mannich Reactions: Facile Access to the Tetrahydroprotoberberine Core
Authors: Ma Longle , Seidel Daniel
Published: July 2015

Cyclic amines such as pyrrolidine undergo redox‐annulations with 2‐formylaryl malonates. Concurrent oxidative amine α‐CH bond functionalization and reductive N‐alkylation render this transformation redox‐neutral. This redox‐Mannich process provides regioisomers of classic Reinhoudt reaction products as an entry to the tetrahydroprotoberberine core, enabling the synthesis of (±)‐thalictricavine and its epimer. An unusually mild amine‐promoted dealkoxycarbonylation was discovered in the course of these studies.
ChemInform Abstract: Single‐Crystal Structure Determination of NO2SbF6, XeF5SbF6 and XeF5Sb2F11.
Authors: Mazej Zoran , Goreshnik Evgeny A.
Published: July 2015

The title compounds are prepared according to the literature and used for single crystal growth in a T‐shaped fluoroethylene‐hexafluoropropylene crystallization apparatus.
ChemInform Abstract: High‐Pressure Synthesis and Crystal Structures of the Strontium Oxogallates Sr2Ga2O5 and Sr5Ga6O14.
Authors: Kahlenberg Volker , Goettgens Valerie , Mair Philipp , Schmidmair Daniela
Published: July 2015

Single‐crystals of Sr2Ga2O5 (I) and Sr5Ga6O14 (II) are prepared by reaction of a 2:1 molar mixture of SrCO3 and Ga2O3 in air (Pt crucible, 1100 °C, 1 d) and subsequent hot‐press annealing (piston‐cylinder apparatus, 1.5 GPa/3.0 GPa, 1000 °C, 72 h).
ChemInform Abstract: On the Ambient Pressure Polymorph of K2Ca3Si3O10 — An Unusual Mixed‐Anion Silicate and Its Structural and Spectroscopic Characterization.
Authors: Schmidmair Daniela , Kahlenberg Volker , Perfler Lukas , Tribus Martina , Hildebrandt Johannes , Toebbens Daniel M.
Published: July 2015

An ambient pressure polymorph of K2Ca3Si3O10 is prepared by firing and annealing a 1:3:3 molar mixture of K2CO3, CaCO3, and amorphous SiO2 (corundum boat, 900 °C, 24 h).
ChemInform Abstract: Crystal Structure of Barium Perchlorate Anhydrate, Ba(ClO4)2, from Laboratory X‐Ray Powder Data.
Authors: Lee Jeonghoo H. , Kang Ji Hoon , Lim Sung‐Chul , Hong Seung‐Tae
Published: July 2015

The title compound is obtained by heating Ba(ClO4)2·xH2O at 423 K in vacuum for 6 h.
ChemInform Abstract: Crystal Structure of the Fe‐Member of Usovite.
Authors: Weil Matthias
Published: July 2015

Crystals of Ba2CaFeAl2F14 (idealized composition) are obtained by solid state reaction of a stoichiometric mixture of BaF2, CaF2, and AlF3 (Mo foil covered C tool steel reactor, 1173 K, 1 d; cooling to 973 K with a rate of 10 K/h).
ChemInform Abstract: Effects of Te(IV) Oxo‐Anion Incorporation into Thorium Molybdates and Tungstates.
Authors: Xiao Bin , Klinkenberg Martina , Bosbach Dirk , Suleimanov Evgeny V. , Alekseev Evgeny V.
Published: July 2015

Compounds (IV), (V), (VII), and (VIII) are characterized by powder and single crystal XRD, SEM/EDS, and Raman spectroscopy.
ChemInform Abstract: Highly Regio‐ and Stereoselective Hydrosilylation of β‐Fluoroalkylated α,β‐Unsaturated Ketones.
Authors: Ikeda Natsumi , Konno Tsutomu
Published: July 2015

Co‐catalyzed hydrosilylation of β‐fluoroalkylated unsaturated ketones (I) affords the hydrosilylated adducts (III) in a highly regio‐ and stereoselective fashion.
ChemInform Abstract: Investigation on the Asymmetric Addition Reactions Between Varied Nonaromatic Aldehydes and Diethylzinc Catalyzed by Chiral Phosphoramide and Thiophosphorodiamide Ligands.
Authors: Li Fangling , Huang Huayin , Zong Hua , Bian Guangling , Song Ling
Published: July 2015

Both ligands QUI and TPA show high efficiency in the title reaction.
ChemInform Abstract: Pyrimidine‐Derived Prolinamides as Recoverable Bifunctional Organocatalysts for Enantioselective Inter‐ and Intramolecular Aldol Reactions under Solvent‐Free Conditions.
Authors: Vizcaino‐Milla Pascuala , Sansano Jose M. , Najera Carmen , Fiser Bela , Gomez‐Bengoa Enrique
Published: July 2015

Chiral prolinamide and 1,2‐aminocyclohexane derived pyrimidines are developed and applied as recyclable catalyst for the cross‐aldol reaction of ketones and aldehydes.
ChemInform Abstract: Photocatalytic Secondary Amine Synthesis from Azobenzenes and Alcohols on TiO2 Loaded with Pd Nanoparticles.
Authors: Selvam Kaliyamoorthy , Sakamoto Hirokatsu , Shiraishi Yasuhiro , Hirai Takayuki
Published: July 2015

An easily recoverable and recyclable heterogeneous catalyst renders possible the synthesis of secondary amines from azobenzenes (I) and alcohols (II) or (IV) under mild reaction conditions.
ChemInform Abstract: Efficient Synthesis of 2,3‐Dimethoxy‐5‐methyl‐6‐morpholinomethyl‐1,4‐benzoquinone Hydrochloride.
Authors: Wang Jin , Liao Teng‐huo‐sheng , Yang Jian
Published: July 2015

The title compound (VII) is prepared by a reaction sequence starting from 2,3,4,5‐tetramethoxytoluene (I) via Blanc reaction, oxidation and alkylation with 63% overall yield.
ChemInform Abstract: Copper‐Catalyzed Direct Transformation of Secondary Allylic and Benzylic Alcohols into Azides and Amides: An Efficient Utility of Azide as a Nitrogen Source.
Authors: Rokade Balaji V. , Gadde Karthik , Prabhu Kandikere Ramaiah
Published: July 2015

A one‐pot formation of azides from allylic alcohols (I) and (III) followed by Cu(II)‐perchlorate and DDQ mediated azide decomposition results in the direct synthesis of diarylamides.
ChemInform Abstract: Tandem Synthesis of Bicyclic ortho‐Aminocarbonitrile Derivatives in Ionic Liquids.
Authors: Wan Y. , Zhang X.‐X. , Zhao L.‐L. , Wang C. , Chen L.‐F. , Liu G.‐X. , Huang S.‐Y. , Yue S.‐N. , Zhang W.‐l. , Wu H.
Published: July 2015

An efficient synthesis of 2‐aminonaphthalenetricarbonitriles (IV) (15 examples) via multicomponent condensation of cyclohexanone with aromatic aldehydes and two equivalents of malononitrile is given.
ChemInform Abstract: The Asymmetric Synthesis of CF3‐Containing Spiro[pyrrolidin‐3,2′‐oxindole] Through the Organocatalytic 1,3‐Dipolar Cycloaddition Reaction.
Authors: Yan Wenjin , et al.
Published: July 2015

A series of unprecedented ketimines, obtained by condensation of isatins with trifluoroethylamine, is used in an asymmetric, organocatalyzed 1,3‐dipolar cycloaddition reaction providing trifluoromethylated spirooxindoles bearing four contiguous stereocenters.
ChemInform Abstract: Nitrative Spirocyclization Mediated by TEMPO: Synthesis of Nitrated Spirocycles from N‐Arylpropiolamides, tert‐Butyl Nitrite and Water.
Authors: Yang Xu‐Heng , Ouyang Xuan‐Hui , Wei Wen‐Ting , Song Ren‐Jie , Li Jin‐Heng
Published: July 2015

A new protocol for nitrative spirocyclization of alkynes is described.
ChemInform Abstract: Unusual 1,2‐Aryl Migration in Pd(II)‐Catalyzed Aza‐Wacker‐Type Cyclization of 2‐Alkenylanilines.
Authors: Youn So Won , Lee So Ra
Published: July 2015

The unprecedented title transformation affords C3‐substituted indole derivatives (III) and (VI) and is found to be operative across a variety of substrates with predictable migratory aptitude.
ChemInform Abstract: Rhodium‐Catalyzed Direct C7 Alkynylation of Indolines.
Authors: Jin Ning , Pan Changduo , Zhang Honglin , Xu Pan , Cheng Yixiang , Zhu Chengjian
Published: July 2015

An efficient rhodium(III)‐catalyzed direct C‐7 alkynylation of indoline C—H bonds with the alkynylated hypervalent iodine reagents is developed.
ChemInform Abstract: Metal‐Free [3 + 2] Cycloaddition of Azides with Tf2C=CH2 for the Regioselective Preparation of Elusive 4‐(Trifluoromethylsulfonyl)‐1,2,3‐triazoles.
Authors: Alcaide Benito , Almendros Pedro , Lazaro‐Milla Carlos
Published: July 2015

Starting material (I) forms in situ the reactive Tf2C=CH2.
ChemInform Abstract: Al(OTf)3‐Catalyzed Preparation of 4‐Hydroxy‐3‐propargylic Coumarins and Subsequent Regioselective Cyclization Towards Furo‐ or Pyrano[3,2‐c]coumarins.
Authors: Ponra Sudipta , Gohain Mukut , van Tonder Johannes H. , Bezuidenhoudt Barend C. B.
Published: July 2015

The potentially bioactive furo[3,2‐c]coumarin or pyrano[3,2‐c]coumarin derivatives (IV) and (V), resp., are obtained by organocatalytic (DBU) or metallo‐organocatalytic (CuBr/NMM) cyclization of readily accessible 4‐hydroxy‐3‐(prop‐2‐ynyl)coumarins (III).
ChemInform Abstract: Gold(I)‐Catalyzed Oriented Assembly of Dihydropyridines.
Authors: Li Yufeng , Wu Zhengguang , Pan Yi , Huang Hao , Shi Jie , Bu Hongzhong , Ma Hongfei , Liang Yingying , Huang Binbin
Published: July 2015

Multisubstituted dihydropyridines (III) are efficiently obtained from methyl propiolate (II) and propargylamines (I) with high regioselectivity.
ChemInform Abstract: Stereo‐ and Regioselective [2 + 2] Photocycloaddition in a Bis(styrylquinoline) Dyad.
Authors: Budyka Mikhail F. , Gavrishova Tatiana N. , Potashova Natalia I. , Chernyak Alexander V.
Published: July 2015

The newly synthesized dyad (III) connecting two styrylquinoline chromophores by an o‐xylylene bridge undergoes [2 + 2] photocycloaddition with quantitative formation of a single rctt cyclobutane derivative (IV).
ChemInform Abstract: Clerodane Type Diterpene as a Novel Antifungal Agent from Polyalthia longifolia var. Pendula.
Authors: Bhattacharya Asish K. , Chand Hemender R. , John Jyothis , Deshpande Mukund V.
Published: July 2015

Diterpene (I) is isolated from the methanolic extract of the leaves of Polyalthia longifolia var.
ChemInform Abstract: Gold and Silver Catalysis: From Organic Transformation to Bioconjugation
Authors: Lo Vanessa Kar‐Yan , Chan Anna On‐Yee , Che Chi‐Ming
Published: July 2015

Review: [64 refs.
ChemInform Abstract: Arylsulfonylmethyl Isocyanides: A Novel Paradigm in Organic Synthesis
Authors: Kaur Tanpreet , Wadhwa Preeti , Sharma Anuj
Published: July 2015

Review: [advancements in the application of p‐tosylmethyl isocyanide (TosMIC), as a privileged reagent to access biologically relevant fused heterocycles and some natural products; 84 refs.
ChemInform Abstract: Recent Advances in the Synthesis of 2‐Pyrones
Authors: Lee Jong Seok
Published: July 2015

Review: and application to the synthesis of marine natural products; 96 refs.
ChemInform Abstract: Prominent Ligand Types in Modern Cross‐Coupling Reactions
Authors: Deangelis Andrew , Colacot Thomas J.
Published: July 2015

Review: 454 refs.
ChemInform Abstract: Recent Advances in Polyoxometalate‐Catalyzed Reactions
Authors: Wang Sa‐Sa , Yang Guo‐Yu
Published: July 2015

Review: 657 refs.
ChemInform Abstract: DNA‐Protein Crosslinks: Formation, Structural Identities, and Biological Outcomes
Authors: Tretyakova Natalia Y. , Groehler Arnold IV , Ji Shaofei
Published: July 2015

Review: 68 refs.
ChemInform Abstract: Effects of Morphology on the Electrochemical Performances of Li3V2(PO4)3 Cathode Material for Lithium Ion Batteries
Authors: Wei Chuanliang , He Wen , Zhang Xudong , Xu Fengxiu , Liu Qinze , Sun Caiyun , Song Xin
Published: July 2015

Review: effects of morphology modifications such as porous structure, spherical structure, core—shell structure, rod‐like structure, plate‐like structure, nanofiber structure and flower‐like structures; 125 refs.
ChemInform Abstract: Blue Light: A Fascinating Journey (Nobel Lecture)
Authors: Akasaki Isamu
Published: July 2015

Review: description of the historical progress that led to the invention of the first blue LED and related optical devices; 67 refs.
ChemInform Abstract: Synthesis and Applications of Porous Organic Cages
Authors: Evans Jack D. , Sumby Christopher J. , Doonan Christian J.
Published: July 2015

Review: 55 refs.
The NEWT platform: an extensible plugin framework for creating ReSTful HPC APIs
Authors: Cholia Shreyas , Sun Terence
Published: July 2015

This work describes the NEWT platform, a framework for creating ReSTful web APIs for high‐performance scientific computing. The NEWT platform is designed to be a customizable framework that can be deployed at a high‐performance computing center and enables access to various backend resources and services through a common web API. The goal of this effort is to create a service that can be plugged into multiple backend resources and can easily be extended while presenting a standard interface to the consumer with common semantics. This effort also updates the NEWT API that has been deployed at the National Energy Research Scientific Computing Center since 2010 and provides additional structure and consistency across the API. Copyright © 2015 John Wiley & Sons, Ltd.
Nanostructured Double Perovskite Cathode With Low Sintering Temperature For Intermediate Temperature Solid Oxide Fuel Cells
Authors: Kim Seona , Jun Areum , Kwon Ohhun , Kim Junyoung , Yoo Seonyoung , Jeong Hu Young , Shin Jeeyoung , Kim Guntae
Published: July 2015

This study focuses on reducing the cathode polarization resistance through the use of mixed ionic electronic conductors and the optimization of cathode microstructure to increase the number of electrochemically active sites. Among the available mixed ionic electronic conductors (MIECs), the layered perovskite GdBa0.5Sr0.5CoFeO5+δ (GBSCF) was chosen as a cathode material for intermediate temperature solid oxide fuel cells owing to its excellent electrochemical performance and structural stability. The optimized microstructure of a GBSCF–yttria‐stabilized zirconia (YSZ) composite cathode was prepared through an infiltration method with careful control of the sintering temperature to achieve high surface area, adequate porosity, and well‐organized connection between nanosized particles to transfer electrons. A symmetric cell shows outstanding results, with the cathode exhibiting an area‐specific resistance of 0.006 Ω cm2 at 700 °C. The maximum power density of a single cell using Ce–Pd anode with a thickness of ∼80 μm electrolyte was ∼0.6 W cm−2 at 700 °C.
Age‐related changes in emotional face processing across childhood and into young adulthood: Evidence from event‐related potentials
Authors: MacNamara Annmarie , Vergés Alvaro , Kujawa Autumn , Fitzgerald Kate D. , Monk Christopher S. , Phan K. Luan
Published: July 2015

Socio‐emotional processing is an essential part of development, and age‐related changes in its neural correlates can be observed. The late positive potential (LPP) is a measure of motivated attention that can be used to assess emotional processing; however, changes in the LPP elicited by emotional faces have not been assessed across a wide age range in childhood and young adulthood. We used an emotional face matching task to examine behavior and event‐related potentials (ERPs) in 33 youth aged 7–19 years old. Younger children were slower when performing the matching task. The LPP elicited by emotional faces but not control stimuli (geometric shapes) decreased with age; by contrast, an earlier ERP (the P1) decreased with age for both faces and shapes, suggesting increased efficiency of early visual processing. Results indicate age‐related attenuation in emotional processing that may stem from greater efficiency and regulatory control when performing a socio‐emotional task. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 58:27–38, 2016.
NK cells modulate the lung dendritic cell‐mediated Th1/Th17 immunity during intracellular bacterial infection
Authors: Shekhar Sudhanshu , Peng Ying , Gao Xiaoling , Joyee Antony G , Wang Shuhe , Bai Hong , Zhao Lei , Yang Jie , Yang Xi
Published: July 2015

The impact of the interaction between NK cells and lung dendritic cells (LDCs) on the outcome of respiratory infections is poorly understood. In this study, we investigated the effect and mechanism of NK cells on the function of LDCs during intracellular bacterial lung infection of Chlamydia muridarum in mice. We found that the naive mice receiving LDCs from C. muridarum‐infected NK‐cell‐depleted mice (NK‐LDCs) showed more serious body weight loss, bacterial burden, and pathology upon chlamydial challenge when compared with the recipients of LDCs from infected sham‐treated mice (NK+LDCs). Cytokine analysis of the local tissues of the former compared with the latter exhibited lower levels of Th1 (IFN‐γ) and Th17 (IL‐17), but higher levels of Th2 (IL‐4), cytokines. Consistently, NK‐LDCs were less efficient in directing C. muridarum‐specific Th1 and Th17 responses than NK+LDCs when cocultured with CD4+ T cells. In NK cell/LDC coculture experiments, the blockade of NKG2D receptor reduced the production of IL‐12p70, IL‐6, and IL‐23 by LDCs. The neutralization of IFN‐γ in the culture decreased the production of IL‐12p70 by LDCs, whereas the blockade of TNF‐α resulted in diminished IL‐6 production. Our findings demonstrate that NK cells modulate LDC function to elicit Th1/Th17 immunity during intracellular bacterial infection.
Extreme rainfall and its impact on cultivated landscapes with particular reference to Britain
Authors: Boardman John
Published: July 2015

Extreme rainfall events (>50 mm day−1) falling on cultivated land which is relatively bare of vegetation cover, typically give rise to networks of rills and gullies with ephemeral gullies in depressions and valley bottoms. Farming practices such as the removal of field boundaries, the presence of wheelings and rolled surfaces encourage runoff. The coincidence of vulnerable crops such as maize, potatoes and sugar beet with erodible soils and sloping sites may lead to high rates of erosion associated with single events or wet seasons. Not all extreme rainfall events lead to runoff and erosion, this depends on timing with respect to the growing crop. Rates of erosion associated with extreme events may be high but when placed in a long‐term temporal context, they tend to be quite low. Extreme events frequently lead to off‐site impacts most notably muddy flooding of properties and the pollution of watercourses. Landscapes may be protected from extreme events by standard soil conservation techniques; off‐site impacts may similarly be alleviated by flood‐protection measures. In both cases, the challenge is to put in place adequate economic incentives, social pressures and governmental policy frameworks to incentivise effective action. Predicted rainfall changes in the future include wetter winters and increases in rain per rain‐day. In this case, the risk of erosion on cultivated land will increase. However, erosion mitigation strategies should still address the issue of the incidence of high‐risk crops on vulnerable sites. Copyright © 2015 John Wiley & Sons, Ltd.
Effect of ammonia stress on nitrogen metabolism of Ceratophyllum demersum
Authors: Gao Jingqing , Li Linshuai , Hu Zhiyuan , Yue Hui , Zhang Ruiqin , Xiong Zhiting
Published: July 2015

The objective of the present study was to determine the effect of total ammonia N concentration and pH on N metabolism of Ceratophyllum demersum and to evaluate stress as a result of inorganic N enrichment in the water column on submerged macrophytes. Carefully controlled pH values distinguished between the effects of un-ionized NH3 and ionized NH4+. The results showed that the most obvious consequence of ammonia addition was an overall increase in ammonia content and decrease in nitrate content in all tissues of fertilized plants. The activities of nitrate reductase and glutamine synthetase were inhibited by long-term ammonia addition. At the same time, ammonia addition significantly decreased soluble protein content and increased free amino acid content in all treatments. Another clear effect of ammonia addition was a decrease in carbon reserves. Therefore, the authors concluded that increased ammonia availability could affect plant survival and lead to a decline in C. demersum proliferation through a decrease in their carbon reserves. This interaction between N and C metabolism helps to explain changes in benthic vegetation as a result of steadily increasing coastal water eutrophication. Environ Toxicol Chem 2016;35:205–211. © 2015 SETAC
Hedge Ratio Prediction with Noisy and Asynchronous High‐Frequency Data
Authors: Lai Yu‐Sheng
Published: July 2015

A growing body of literature has focused on the design of covariance estimators for identifying when high‐frequency asset prices are asynchronous and contaminated by microstructure noise. This paper presents a comparison of the prediction ability of covariance estimators within a high‐frequency‐based multivariate volatility model for hedge ratio prediction. Empirical results show that the noise‐free predictions are superior to those contaminated by the noise, with the utility gains being particularly substantial for hedgers with pronounced risk aversion. The results demonstrate the importance of removing microstructure noise and asynchronous trading from covariance estimation to achieve accurate hedge ratio prediction. © 2015 Wiley Periodicals, Inc. Jrl Fut Mark 36:295–314, 2016
Prediction of supercritical CO2/brine relative permeability in sedimentary basins during carbon dioxide sequestration
Authors: Tatar Afshin , Shokrollahi Amin , Lee Moonyong , Kashiwao Tomoaki , Bahadori Alireza
Published: July 2015

This study aims to accurately determine supercritical CO2/brine relative permeability, using a hybrid Genetic Algorithm‐Radial Basis Function (GA‐RBF) neural network. CO2 sequestration, along with some enhanced oil recovery (EOR) processes, demands an exact knowledge of relative permeability in order to ensure the viability of the operation. Previous studies have shown that errors in CO2/brine relative permeability data might result in a four‐fold error in injectivity estimation. This, as well as several recent studies regarding the relative permeability of CO2/brine systems, has indicated the importance of this parameter. The developed GA‐RBF model was determined to be in excellent accordance with experimental data, yielding average absolute relative deviations (AARD) of 4.66% and 2.11% for CO2 and brine relative permeability, respectively. In addition, comprehensive comparisons between classic models and the proposed GA‐RBF model have been carried out. Based on these comparisons, it may be concluded that the proposed model is superior to the classic method (simple correlation) in terms of its accuracy in determining the viability of CO2 sequestration operations. © 2015 Society of Chemical Industry and John Wiley & Sons, Ltd
A simple water balance model adapted for soil water repellency: application on Portuguese burned and unburned eucalypt stands
Authors: Nunes João Pedro , Malvar Maruxa , Benali Akli Ait , Rial Rivas María Ermitas , Keizer Jan Jacob
Published: July 2015

Soil water repellency can impact soil hydrology, overland flow generation and associated soil losses. However, current hydrological models do not take it into account, which creates a challenge in repellency‐prone regions. This work focused on the adaptation for soil water repellency of a daily water balance model. Repellency is estimated from soil moisture content using site‐specific empirical relations and used to limit maximum soil moisture. This model was developed and tested using approximately 2 years of data from one long‐unburned and two recently burned eucalypt plantations in northern Portugal, all of which showed strong seasonal soil water repellency cycles. Results indicated important improvements for the burned plantations, with the Nash–Sutcliffe efficiency increasing from −0.55 and −0.49 to 0.55 and 0.65. For the unburned site, model performance was already good without the modification and efficiency only improved slightly from 0.71 to 0.74, mostly due to the better simulation of delayed soil wetting after dry periods. Results suggested that even a simple approach to simulate soil water repellency can markedly improve the performance of hydrological models in eucalypt forests, especially after fire. Copyright © 2015 John Wiley & Sons, Ltd.
Rice consumption and cancer incidence in US men and women
Authors: Zhang Ran , Zhang Xuehong , Wu Kana , Wu Hongyu , Sun Qi , Hu Frank B. , Han Jiali , Willett Walter C. , Giovannucci Edward L.
Published: July 2015

While both the 2012 and 2014 Consumer Reports concerned arsenic levels in US rice, no previous study has evaluated long‐term consumption of total rice, white rice and brown rice in relation to risk of developing cancers. We investigated this in the female Nurses' Health Study (1984–2010), and Nurses' Health Study II (1989–2009), and the male Health Professionals Follow‐up Study (1986–2008), which included a total of 45,231 men and 160,408 women, free of cancer at baseline. Validated food frequency questionnaires were used to measure rice consumption at baseline and repeated almost every 4 years thereafter. We employed Cox proportional hazards regression model to estimate multivariable relative risks (RRs) and 95% confidence intervals (95% CIs). During up to 26 years of follow‐up, we documented 31,655 incident cancer cases (10,833 in men and 20,822 in women). Age‐adjusted results were similar to multivariable‐adjusted results. Compared to participants with less than one serving per week, the multivariable RRs of overall cancer for individuals who ate at least five servings per week were 0.97 for total rice (95% CI: 0.85–1.07), 0.87 for white rice (95% CI: 0.75–1.01), and 1.17 for brown rice (95% CI: 0.90–1.26). Similar non‐significant associations were observed for specific sites of cancers including prostate, breast, colon and rectum, melanoma, bladder, kidney, and lung. Additionally, the null associations were observed among European Americans and non‐smokers, and were not modified by BMI. Long‐term consumption of total rice, white rice or brown rice was not associated with risk of developing cancer in US men and women.
Monitoring the laccase reaction of vanillin and poplar hydrolysate
Authors: Sóti Valentin , Jacquet Nicolas , Apers Sandra , Richel Aurore , Lenaerts Silvia , Cornet Iris
Published: July 2015

BACKGROUND

Laccase is an intensively researched enzyme for industrial use. Except for decolorization measurements, high performance liquid chromatography (HPLC) analysis is the conventional method for monitoring the phenolic removal during laccase enzyme reaction. This paper reports an investigation of the continuous UV absorbance follow‐up of the laccase reaction with steam pretreated poplar hydrolysate.

RESULTS

Vanillin was used as a model substrate and lignocellulose xylose rich fraction (XRF) as a biologically complex substrate for laccase detoxification. The reaction was followed by HPLC‐UV as well as by UV spectrometric measurements. Results suggest that the reaction can be successfully monitored by measuring the change of UV absorbance at 280 nm, without previous compound separation. In the case of XRF experiments the spectrophotometric follow‐up is especially useful, as HPLC analysis takes a long time and provides less information than in the case of single substrates. The method seems to be suitable for optimization and process control.

CONCLUSION

The results obtained can help to construct a fast, easy and straightforward monitoring system for laccase–phenolic substrate reactions. © 2015 Society of Chemical Industry
Elevated serum creatinine and low albumin are associated with poor outcomes in patients with liposarcoma
Authors: Panotopoulos Joannis , Posch Florian , Funovics Philipp T. , Willegger Madeleine , Scharrer Anke , Lamm Wolfgang , Brodowicz Thomas , Windhager Reinhard , Ay Cihan
Published: July 2015

Low serum albumin levels and impaired kidney function have been associated with decreased survival in patients with a variety of cancer types. In a retrospective cohort study, we analyzed 84 patients with liposarcoma treated at from May 1994 to October 2011. Uni‐ and multivariable Cox proportional hazard models and competing risk analyses were performed to evaluate the association between putative biomarkers with disease‐specific and overall survival. The median age of the study population was 51.7 (range 19.6–83.8) years. In multivariable analysis adjusted for AJCC tumor stage, serum creatinine was highly associated with disease‐specific survival (Subdistribution Hazard ratio (SHR) per 1 mg/dl increase = 2.94; 95%CI 1.39–6.23; p = 0.005). High albumin was associated with improved overall and disease‐specific survival (Hazard Ratio (HR) per 10 units increase = 0.50; 95%CI 0.26–0.95; p = 0.033 and SHR = 0.64; 95%CI 0.42–1.00; p = 0.049). The serum albumin‐creatinine‐ratio emerged to be associated with both overall and disease‐specific survival after adjusting for AJCC tumor stage (HR = 0.95; 95%CI 0.92–0.99; p = 0.011 and SHR = 0.96; 95%CI 0.93–0.99; p = 0.08). Our study provides evidence for a tumor‐stage‐independent association between higher creatinine and lower albumin with worse disease‐specific survival. Low albumin and a high albumin‐creatinine‐ratio independently predict poor overall survival. Our work identified novel prognostic biomarkers for prognosis of patients with liposarcoma. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:533–538, 2016.
Robotic surgery of the pancreas: The current state of the art
Authors: Stafford Anthony T. , Walsh R. Matthew
Published: July 2015

Pancreatic surgery is one of the most technically challenging and complex types of surgery. Most pancreatic surgery is performed with the open technique, yet minimally invasive surgery has become the standard of care for many other intra‐abdominal operations. The unique qualities of the robotic platform have made this approach to pancreatic surgery safe and feasible with at least equivalent if not better results than the open platform in terms of surgical and oncological outcomes. J. Surg. Oncol. 2015; 112:289–294. © 2015 Wiley Periodicals, Inc.
Epidural analgesia does not influence anastomotic leakage incidence after open colorectal surgery for cancer: A retrospective study on 1,474 patients
Authors: Piccioni Federico , Mariani Luigi , Negri Marta , Casiraghi Claudia , Belli Filiberto , Leo Ermanno , Langer Martin
Published: July 2015

Background

Anastomotic leakage is a major cause of morbidity after colorectal surgery. Epidural analgesia is the most effective method for postoperative pain relief after major abdominal surgery. Anyhow, its effect on anastomotic leakage rate is still controversial. This study aimed to compare epidural versus intravenous analgesia as risk factor for anastomotic leakage requiring reoperation in patients undergoing open colorectal surgery for cancer.

Methods

A retrospective study on 1,474 patients was performed. The Cox proportional hazards model was used to study the relation between primary and secondary factors of risk and anastomotic leakage occurrence within 30 days after elective operation.

Results

Overall 30‐day anastomotic leakage requiring reoperation was 4.9% (95%CI: 3.8–6.0%). No difference in anastomotic leakage occurrence was observed between the epidural analgesia group and the intravenous analgesia group (Hazard ratio: 0.94; 95%CI: 0.53–1.67%; P = 0.8338). Females had a rate of anastomotic leakage 43% lower than males (P = 0.0301). The diverting stoma resulted to be protective for anastomotic leakage occurrence (P = 0.0052). AL significantly increased postoperative median length of stay but not in‐hospital mortality.

Conclusions

Epidural analgesia does not influence the AL risk after open colorectal surgery for cancer. J. Surg. Oncol. 2015 111:225–230. © 2015 Wiley Periodicals, Inc.