bluuebunny/crossref_metadata_2025 huggingface dataset:
Estudio aerobiológico en Lima, Perú. ¿Tipuana- Tipu, tal vez un nuevo alérgeno?
Authors: Calderón LLosa Oscar Manuel
Published: April 2024

Introduction:Knowledge about local airborne allergens in any geographical area is essential for effective diagnosis and treatment of allergic diseases. Tipuana tipu, tree of the Fabaceae family, native from South America, it is present in the main avenues of metropolitan Lima and in some parks (big gardens) of the city. The objective was to report the Tipuana tipu pollen how a new allergen capable of triggering allergic symptoms. Methods:The pollen counts were made according to standardized technique with a Burkard seven days following the European Aerobiology Society´s Network Group recommendations.1 The trap was installed on the roof of Clinica SANNA el GOLF, San Isidro, which is 20 m high, 12°5'54"S 77°3'6"W in the west-south of the Lima urban area. The sampling period was performed from September 2020 to October 2021. Collection of Tipuana tipu pollens and Preparation of Tipuana tipu pollen extracts 1:20 w/v was done using a previously described method.2We carried out systematic skin prick testing with Tipuana tipu pollen extract and other aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis), molds (Cladosporium herbarum, Alternaria alternata, Aspergillus fumigatus, Penicillium notatum), cat and dog danders, Periplaneta americana, grass 6 mix, weed mix (Inmunotek, Spain) on 80 patients (18 to 50 years) seen in our allergy center, they suffering from November to January rhinitis and/or conjunctivitis symptoms. The majority living near avenues and large green areas, where Tipuana trees grew. Results:We found a total of 952 grains/m3 of Tipuana tipu pollen between November 2020 to January 2021, with the maximum concentration of 37 grains/m3 on December 10th. We also found other airborne pollen Types: Poaceae, Myrtaceae, Compositae and Betulaceae.14/80 patients (17.5%) showed positive skin prick test only to Tipuana tipu extract. Most of the patients with positive tests to Tipuana extract presented symptoms of rhinoconjunctivitis during the Tipuana pollination period. Four patients showed positive skin prick test to Tipuana tipu and grass 6 mix extracts, most of the rest of our patients were sensitized to dust mites extracts (Dermatophagoides pteronyssinus).Conclusions:The west-south population of Lima urban city is exposed to Tipuana tipu pollen. We do not found previous publications about Tipuana tipu allergy. Almost 18% of the patients tested in our sample were mono-sensitized to this pollen. The results of this study should be compared with data from the forthcoming years, to identify seasonal and annual fluctuations, extend the traps to other locations in Lima, and of course try to standardize and improve the Tipuana tipu pollen extract.
Análisis de sentimientos acerca de la inmunoterapia con alérgenos en Twitter mediante un modelo de procesamiento natural de lenguaje
Authors: Tarango García Alejandro , Lugo-Reyes Saúl Oswaldo , Alvarez Cardona Aristóteles
Published: April 2024

Objetivo: Analizar los sentimientos acerca de la inmunoterapia alérgeno-específica en Twitter mediante el modelo VADER (Valence Aware Dictionary and sEntiment Reasoner).
Métodos: Se utilizaron tweets relacionados con la inmunoterapia alérgeno-específica obtenidos a través del API (Application Programming Interface) de Twitter. Se incorporaron las palabras clave “allergy shot” en el período comprendido entre el 1 de enero de 2012 y el 31 de diciembre de 2022. Los datos obtenidos fueron procesados, eliminando las URL, nombres de usuarios, hashtags, espacios múltiples y tweets duplicados. Posteriormente, se realizó un análisis de sentimientos utilizando el modelo VADER.
Resultados: Se recolectaron 34,711 tweets, de los que se eliminaron 1928. De los 32,783 tweets restantes, se encontró que el 32.41% de los usuarios expresó un sentimiento negativo, el 31.11% un sentimiento neutral y el 36.47% un sentimiento positivo, con una media de polaridad de 0.02751 (neutral) a lo largo de los 11 años.
Conclusiones: La polaridad media de los tweets acerca de la inmunoterapia alérgeno-específica es neutral a lo largo de los 11 años analizados. Existe un aumento anual en la polaridad media positiva a lo largo de los años, sobre todo entre 2017, 2018 y 2022. La cantidad de tweets disminuyó con el tiempo.
Si algo puede fallar, fallará: el virus Epstein-Barr y su contención inmunitaria
Authors: Gutierrez Guerrero Arturo , Espinosa-Padilla Sara Elva , Lugo-Reyes Saúl Oswaldo
Published: April 2024

El virus Epstein-Barr es un virus gamma herpes que afecta exclusivamente a humanos; fue el primer virus oncogénico descrito y se ha relacionado con más de siete diferentes tipos de cáncer. Curiosamente, el intercambio de genes debido a infecciones virales ha permitido la evolución de los organismos celulares, favoreciendo el desarrollo de nuevas funciones y supervivencia del hospedero. El virus Epstein-Barr  comparte cientos de millones de años de coevolución con la especie humana y más del 95% de la población adulta mundial se ha infectado en algún momento de su vida. La infección se adquiere principalmente durante la infancia, y en la mayoría de los casos aparece sin ninguna manifestación grave aparente. Sin embargo, en los adolescentes y la población joven-adulta, alrededor de un 10 a 30% evolucionan a mononucleosis infecciosa. Las células NK y T CD8+ son células citotóxicas cruciales durante las respuestas antivirales y se ha demostrado que controlan y eliminan la infección por el virus Epstein-Barr. No obstante, cuando se afecta su función efectora, el desenlace puede ser fatal. El objetivo de esta revisión es describir la infección por el virus Epstein-Barr y el papel decisivo de las células NK y T CD8+ durante el control y eliminación de la infección. Además, se discuten brevemente los principales defectos genéticos que afectan a estas células y conllevan a la incapacidad para eliminar el virus. Finalmente, se resalta la necesidad de elaborar una vacuna efectiva contra el virus Epstein-Barr y cómo podrían evitarse los procesos neoplásicos y enfermedades autoinmunes.
Estudio de microbiota fecal revela disbiosis específica en espondiloartritis, según subtipo, actividad de la enfermedad y tratamiento
Authors: Romero-Sánchez Consuelo , Ferrer-Santos Carlos , Abril Deisy , Acosta-Hernández Eduin , De Avila Juliette , Ramos-Casallas Alejandro , Escobar Javier , Bautista-Molano Wilson , Jaimes Diego , Beltrán-Ostos Adriana , Bello-Gualtero Juan Manuel , Flórez-Sarmiento Cristian , Parra-Izquierdo Viviana , Calixto Omar-Javier
Published: April 2024

Introduction: Variability in microbiome composition and metabolic competence affects clinical activity and inflammatory status in spondyloarthritis-SpA.
Aim: To compare the diversity and composition of the gastrointestinal microbiome of patients with SpA.
Methods: MiSeq sequencing of the V3-V4 region of the 16S ribosomal RNA gene was performed on DNA isolated from stool. Patients with concurrent SpA and IBD were excluded.  Differences were assessed for richness and diversity indices by QIIME 2™. Differences between means > 0.2% with a p-value < 0.05 were assumed significant. Institutional ethics committee endorsement.
Results: 69 individuals included, 49 with SpA (ankylosing spondylitis-AS 72.9%, psoriatic arthritis-PsA 18.8%, reactive arthritis-ReA 8.3%) 5 positive controls-dysbiosis and 15 controls-eubiosis. Conventional treatment in 42.9%, anti-IL-17 16.3% and anti-TNF 40.8%.
By subtype, statistically significant differences in favour of AS were found for the diversity indices.  AS vs PsA there was a difference in favour of AS for Clostridium clostridioforme (p=0.002), Gemmiger formicilis (p=0.009), Roseburia inulivorans (p=0.008) and Lachnospira pectinoschiza. AS vs ReA there was a difference in favour of AS for L. pectinoschiza (p=0.009), Ruminococcus callidus (p=0.006), Clostridium ruminantium (p=0.031); G. formicilis (p=0.034). Diversity and richness showed differences in patients with high activity for Simpson's and Pielou's indices. In high activity, lower enrichment of Bacteroides eggerthii (p= 0.0003), C. ruminantium (p= 0.026) and Alistipes putredinis (p= 0.035) was found. The number of ASV was higher in the anti-IL-17 vs conventional group (p=0.025) and a trend between anti-IL-17 vs anti-TNF (p=0.09). In anti-TNF there was a lower proportion for C. clostridioforme (p=0.023), G. formicilis (p=0.030) and R. callidus (p= 0.003). In anti IL-17, Alistipes indistinctus (p= 0.012) was decreased.
Conclusions: There are differences in microbial diversity for SpA subtypes. The level of disease activity is plausible to influence the composition of the faecal microbiota. Anti-TNFα treatment may influence the microbiome environment favouring restoration of the gut microbiota, while anti-IL-17 may maintain an inflammatory environment.
Caso clínico de anafilaxia por gotas oftálmicas
Authors: Tinoco Moran Ivàn , Calderón Llosa Oscar , Olivares Gómez Margarita , Farinango Salazar Víctor , Chérrez Ojeda Iván
Published: April 2024

Introduction:
Anaphylaxis is a severe systemic allergic reaction that can be life-threatening, timely diagnosis and treatment is required in these patients, one of the most frequent triggers is pharmacological.
Our objective is to report the case of a patient who presented anaphylaxis due to eye drops.
Material and methods:
 
A 7-year-old male with a history of rhinitis and asthma with good control. It started with itchy eyes, ophthalmic drops were administered, composition: Polyethylene glycol 400, 0.4%, Propylene glycol 3 mg, polyquad 0.001%, presenting at 15 minutes an episode of anaphylaxis initially characterized by pruritus and intense conjunctival erythema, later nausea, vomiting, sweating, weakness, urticaria/facial angioedema and dyspnea were added, this episode was controlled opportunely with Levocetirizine 5 mg sub lingual and Betametasona 4 mg intramuscular, progressively improving over the next 2 hours.
 
The patient was evaluated by the Allergist, written recommendations were given to the mother in case this reaction occurred again, the use of the drops was prohibited, and the performance of skin test and a probable conjunctival provocation protocolized with the ophthalmic drops were pending.
 
 
Accidentally 2 months later the patient was re-exposed with the same eye drops, presenting a similar reaction 15 minutes after the administration of the medication, they went to the emergency room where he received antihistamine and corticosteroid intravenous treatment, after this re-exposure is confirmed to the ophthalmic drops mentioned above as a trigger of anaphylaxis in this patient.
 
CONCLUSIONS:
We present a case of conjunctival anaphylaxis after application of eye drops, confirmed by re-exposure to the drug. It is essential to give diagnoses, recommendations with treatments and avoidance of the probable triggering agent of the reaction. The administration of immediate medication when the allergic episode begins in these patients can be vital, even more so when they live far from a health center, as was the case in this patient.
Caracterización clínica y demográfica de pacientes colombianos con rinosinusitis crónica con poliposis nasal
Authors: Londoño Sergio , Penagos Juan Carlos , Díaz Diana , Cadena Pedro , Rodríguez Ordóñez Paula
Published: April 2024

Introduction: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is associated with a high daily burden of symptoms and a significant impact on health-related quality of life (HRQoL) (HRQoL). To date, the clinical and demographic characteristics of Colombian patients with CRSwNP are unknown.
Objectives: The aim of this study is to present the baseline clinical and demographic characteristics of CRSwNP patients over the age of 18 enrolled in a Patient Support Program (PSP) prior to biologic treatment.
Methodology: Descriptive, cross-sectional study performed in a Colombian CRSwNP asthma PSP sponsored by Sanofi from Aug-2021 to Jul-2022. Data was collected from CRSwNP patients, prior to the start of Dupilumab treatment, who consented to the use of their data.  The following information was reported: Age, reporting city, treating medical specialty, comorbidities, and persistence of treatment.
Results: 339 patients were included, 171 (50.4%) were women and 168 (49.6%) were men (Figure 1). The mean age at Dupilumab treatment initiation was 52.4 years. 62.8% began treatment during adulthood (26-59y), while 34.1% started at elderly (+60y) and 3.1% were young adults (18-25y). Most cases (29.7%) were included in Bogotá, followed by Antioquia (19%), Valle del Cauca (7.3%) and the remaining 44% nationwide (Figure 2).
Comorbidities were present in 67.1% of the patients, with diagnosis of allergic rhinitis, atopic dermatitis, asthma, and other non-type 2 inflammatory diseases (Figure 3). Nasal surgical history was present in 89.6% of the patients, most of them with one to three previous surgeries (Figure 4).
Continuous treatment was observed in 70.3% of patients for 6 to 12 months, in 21.3% for more than 12 months and in 8.4% for less than 6 months. The most frequently treating medical specialty was otorhinolaryngology (79,6%), followed by allergology (16%) and other medical professionals (4.4%).
Conclusions:

There is concordance with the literature on a higher presentation of the disease in women than in men.
There is a large proportion of patients with nasal surgical history and type 2 inflammatory comorbidities by the moment of biologic treatment initiation.
The care and identification of CRSwNP colombian patients is mainly provided by otorhinolaryngologists, followed by allergologists.
Uso tópico de Cannabis para enfermedades inflamatorias, en pacientes de la IPS Salud Social de Barranquilla
Authors: Juan Calderón  , Parga Lozano Carlos Hernando , Nohemí Santodomingo  , Paola Gutiérrez  , Fanny Lambraño
Published: April 2024

Introduction: Cannabis has been the subject of research for the treatment of various diseases, including arthritis, epilepsy, and rotator cuff syndrome.
Objective: To relate the topical use of cannabis as an analgesic therapeutic alternative in patients with some inflammatory diseases in Salud Social I.P.S during May to July 2023.
Methodology: An analytical, retrospective study was carried out. The population from which the sample was obtained corresponds to patients diagnosed with Arthrosis, Unspecified, Non Toxic Multinodular Goiter, Epilepsy, Unspecified Type Venous Insufficiency (Chronic) (Peripheral), Unspecified Lumbago, Secondary Gonarthrosis, Rotator Cuff Syndrome, Carpal Tunnel Syndrome, in Salud Social I.P.S of Barranquilla, Atlántico. A sample of 23 patients diagnosed with these pathologies was obtained by non-probabilistic convenience sampling.
Results and discussion: All patients showed pain relief after two months of follow-up, two experienced adverse effects. Some studies suggest that cannabinoids present in cannabis, such as CBD and THC, may have analgesic and anti-inflammatory properties that could alleviate pain and inflammation associated with these conditions. This is consistent with the present study.
Conclusion: Topical cannabis is presented as a therapeutic alternative in inflammatory diseases, however, it is important to highlight that research on the use of cannabis in these diseases is limited and more studies are needed to fully understand its effects and potential benefits.
Inmunofenotipo por citometría espectral, revela un perfil de linfopenia asociado a desregulación con aumento de linfocitos de memoria efectora en paciente con mutación en el gen ITPR3
Authors: Muñoz Mejía Cesar Andrés , De Vivero Maria Mónica , Acevedo Nathalie
Published: April 2024

Antecedentes: Las variantes en genes del transporte de calcio intracelular han sido asociadas a inmunodeficiencias sindrómicas con un fenotipo IDCG.
Reporte de caso: Niña de siete años, de padres no consanguíneos, en Cartagena-Colombia. A los dos meses de vida, presenta hematoquecia y se diagnostica con proctolitis alimentaria sin mejoría con restricción a leche, trigo y huevo, desarrollando desnutrición. A los ocho meses, una biopsia de colon muestra hiperplasia linfoide crónica, cursa con anemia, eosinofilia, pero IgE total y específica a alimentos normales. A los cuatro años, el Servicio de Inmunología la encuentra asintomática, recuperada nutricionalmente y sin sensibilización alérgica, pero persiste eosinofilia y calprotectina elevada, sugiriendo una enfermedad inflamatoria intestinal de inicio temprano. Las inmunoglobulinas fueron normales, poblaciones linfocitarias con linfopenia CD3, CD4 y CD8. A los seis años, presenta dermatitis atópica, sigue con calprotectina elevada y linfopénica. El inmunofenotipo por citometría espectral mediante Cytek®cFluor®Immunoprofiling-Kit14, mostró linfopenia e inversión CD4/CD8. Los linfocitos T-vírgenes CD4+ y CD8+ estaban disminuidos, en cambio las poblaciones de memoria efectora T-CD8+CD45RA-CCR7- y T-CD8+CD45RA+CCR7– estaban expandidas. Los linfocitos T-CD4+ de memoria efectora y central, también estaban aumentados1 (Imagen 1). El exoma reveló una variante heterocigótica en el gen ITPR3 (padre portador), c.7571G>A, p.(Arg2524His); los predictores la clasifican como de potencial efecto deletéreo.
Conclusiones: La clínica y el inmunofenotipo de esta variante candidata difiere de otras relacionadas con el transporte del calcio intracelular. Son necesarios estudios funcionales para validar su causalidad. Una paciente con una variante potencialmente deletérea, presenta un inmunofenotipo con linfopenia CD3 y activación persistente de los linfocitos.
A COMUNIDADE LGBTQIA+ E O PRECONCEITO HISTÓRICO SOCIAL: A RELAÇÃO DE GÊNERO SOB O ASPECTO SOCIOLINGUÍSTICO VARIACIONISTA NO CONTEXTO EDUCACIONAL
Authors: FERNANDES PAULA TORRES , Araújo Karina de Jesus , Almeida Manoel Mourivaldo Santiago
Published: April 2024

O presente artigo tem por objetivo um reparo histórico social por meio de uma revisão bibliográfica e relatos pessoais sobre a homofobia e impulsionar os estudos de gêneros em salas de aula no ensino
Epidemiologia dos acidentes com escorpião no Brasil
Authors: Carvalho Mateus De Oliveira , Oliveira João Gabriel dos Santos , Costa Antonio Samuel Da Silva , Andrade Micássio Fernandes de
Published: April 2024

O escorpionismo, causado principalmente pelo Tityus serrulatus, apresenta riscos significativos à saúde, especialmente em áreas com falta de saneamento básico. Durante a pandemia de Covid-19, medidas
A ARGILA COMO RESQUICIO HISTÓRICO E ANCESTRALIDADE NA ARTE E ARQUITETURA VERNACULAR BRASILEIRA.
Authors: MARTINS MARIA JULIA AVELINO SILVA , FERNANDES FABRICIA DIAS DA CUNHA DE MORAES
Published: April 2024

Embora o Brasil tenha sido colonizado pelos portugueses, a cultura nacional existente está mergulhada na ancestralidade indígena e africana. Um elo notório de tais culturas tradicionais trata-se da ut
Possível representação rupestre do modelo de propriedade indígena no Sítio da Toca da Onça em Pedro Alexandre, Bahia, Nordeste do Brasil
Authors: Lima Ricardo Junio Feitosa
Published: April 2024

Os grafismos rupestres descobertos na Toca da Onça em Pedro Alexandre, Bahia, revelam insights sobre antigas
sociedades. Apesar da dificuldade na interpretação devido à possibilidade de serem símbolos imaginários, nesta
análise, sugerimos que os traços representam o cercamento da propriedade, contendo sua habitação centralizada.
Multi-Pronged Solutions Addressing Barriers to Breast Screening Access in Appalachia
Authors: Safon Cara Brooks , Batten George , Bonilla Gloribel , Robinson Brenna , Camacho Fabian , Harvey Jennifer , Anderson Roger , Hillemeier Marianne Messersmith , Louis Christopher
Published: April 2024

Annual mammography screening is recommended by the US Preventive Services Task Force (USPSTF) and American Cancer Society (ACS) to reduce mortality through early detection of breast cancer. In rural Appalachia, rates of later-stage breast cancer incidence and mortality are higher than national averages. We explored the ways that providers and staff at breast cancer screening facilities employed novel approaches to overcome patient- and facility-level barriers to access to breast cancer screening in the Appalachian region. We conducted 23 semi-structured interviews with 28 clinical providers and staff of breast health facilities in Appalachia. Themes reflect how limiting features of breast screening facilities influenced access to care; the way patient-level barriers presented challenges to access to breast screening; and that external and regulatory forces presented obstacles to access to care. In addition, the unique geographical and geographical attributes of the Appalachian region shaped access and adherence to mammography screening recommendations. Thematic findings highlight that facilities implemented patient-centered strategies to overcome access-related barriers. Results may inform the ways breast cancer screening facilities address suboptimal access to breast health screening. They may also inform future resource allocations to enable facilities to reach breast cancer screening performance goals.
A oferta do café de rua nas capitais São Paulo e Vitória
Authors: Bucciarelli Bruno Barreto , Melo Christiane Barbara Odoki , Souza Flavia Mayer dos Santos , Silva Simone Bueno da , Martyniuk Valdenise Leziér
Published: April 2024

A pandemia gerou impactos sociais e econômicos, como o trabalho informal dos que se ocupam do serviço de café de rua, ampliado na retomada pós isolamento. O artigo analisa as significações construídas pelas instalações do serviço nas ruas de São Paulo (SP) e Vitória (ES), enquanto manifestações do empreendedorismo por necessidade. O corpus foi coletado em dias úteis, no início das manhãs, em diversos pontos das capitais. A semiótica discursiva sustenta a análise e seu método permitiu traçar isotopias conectoras de figuras e temas. Os resultados apontam para a comunicação dos sentidos da informalidade, casualidade e familiaridade, marcados pela presença feminina, pela autonomia imposta aos sujeitos produtor/vendedor e consumidor e pela conexão entre a energia dada pela bebida e o trabalho. Esses significados vêm embebidos no risco vivido por esses sujeitos, aconchegados entre si e alijados da proteção de políticas públicas de trabalho, condições sanitárias, serviços de transporte e saúde.
Evaluating Health Risks of Volatile Organic Compounds in Various UK Environments: Insights from Health Indices
Authors: Holland Rayne , Guy Molly , Anwar. H. Khan M. , E. Shallcross Dudley
Published: April 2024

The health risks of twelve volatile organic compounds (VOCs) across three sites in the UK were analysed across an 11-year period (2013–2023) using US EPA proposed health indices; Inhalation Unit Risk (IUR) and Reference Concentration (RfC) for carcinogenic and non-carcinogenic risk, respectively. Significant decreases in carcinogenic risk were observed over the study period for 1, 3-butadiene, with reductions of 63%, 36%, and 45% at urban traffic, suburban background and rural background sites, respectively. Similar decreases in the carcinogenic risk associated with benzene (52%, 28% and 27%) and toluene (50%, 38% and 51%) are found for the three site types, respectively. However, the carcinogenic risk of these three pollutants still exceeds the acceptable threshold of 1 × 10-6 at the urban traffic and suburban background sites, necessitating further emission control strategies. Conversely, the carcinogenic risk associated with isoprene has increased at the urban traffic site over the study period. The study revealed a decrease of 51%, 39% and 37% of the total non-carcinogenic risk at all three sites over the study period. The seasonal variations in carcinogenic and non-carcinogenic health risks of pollutants with anthropogenic origin exhibit winter maxima and summer minima. Moreover, diurnal variations of pollutants with anthropogenic origin demonstrate a bimodal distribution reflecting that of traffic flow, e.g., peaks around 08:00 LT and 18:00 LT, corresponding with rush hours. This trend demonstrates the influence of traffic sources supported by the characteristic species ratio whereby Toluene/Benzene (T/B) ratios were less than two (0.72, and 0.42 at suburban and rural background sites, respectively), illustrating the influence of vehicular emissions. Despite following the same bimodal trend suggesting the dominance of vehicular emission sources, mean T/B ratios at urban traffic sites were consistently above 2 for all years considered (average 2.76) suggesting other VOC sources are becoming more dominant at this site.
Assessment of physicochemical, minerals and microbiological qualities of borehole and well water: A case study of Akure Metropolis, Nigeria
Authors: Emmanuel Orimisan Abata  , Daniel Ekwere
Published: April 2024

Groundwater constitutes a substantial reservoir of fresh water utilized for agricultural irrigation and drinking, emphasizing the critical importance of safeguarding its availability and quality. Contamination of groundwater can arise from chemical, physical, or microbiological sources, each contributing to various health-related issues. In the region of FUTA Southgate, Southwest Nigeria, an assessment was conducted on the physicochemical and microbiological characteristics of groundwater from hand-dug wells and boreholes to ascertain its suitability for human consumption. The analysis indicated that parameters such as BOD, DO TS, TH, and nitrate content were within the acceptable limits set by the World Health Organization (WHO) and the Nigerian Standard for Drinking Water Quality (NSDQ). However, the presence of heavy metals like Fe, Cu, Cr, Pb, Mn, Cd, and Zn was detected using an atomic absorption spectrometer, revealing a slight level of contamination in both water sources. Furthermore, microbiological examination identified Total Coliform Counts of 382 cfu and 159 cfu in hand-dug wells and boreholes, respectively, indicating fecal contamination. The findings suggest that inadequate sewage systems and improper waste disposal practices contribute to the compromised water quality and elevated nitrate levels in hand-dug wells, rendering the shallow aquifer groundwater unsafe for drinking purposes across all evaluated parameters. Consequently, appropriate treatment and disinfection measures are imperative before utilizing the contaminated borehole and groundwater wells for human consumption or industrial purposes.
Thoracal meningioma and neurological status recovery 6 months postoperative: A case report
Authors: Ilham Pratamanugroho  , Lukas Widhiyanto
Published: April 2024

Introduction: Meningioma is the most common intradural tumor of the spinal cord in adults. Spinal meningioma arises from slow-growing arachnoid cap cells, which are generally located intradural extramedullary and grow laterally into the subarachnoid space to stretch the surrounding arachnoid. Local pain is usually the first major symptom. However, the majority of cases are diagnosed after the onset of neurological deficits or impaired walking. Case Presentation: Woman, 46 years old, with back pain radiating to both legs in the last 2 years before surgery. At 16 months before surgery, she had paralysis of both legs with bowel and bladder incontinence. Preoperative physical examination shows no muscle contraction on both lower extremities, with hypoesthesia in the Thoracal 2 dermatome. MRI examination shows intradural extramedullary mass at the level of the 2nd thoracal that compresses the entire spinal canal. Laminectomy surgery on thoracal 2 and tumor resection in toto were performed. Surgical resection showed a tumor mass of 2x1,2x1cm with a thick, spongy, brownish-yellow consistency. Histopathological examination shows psammomatous type meningioma, WHO Grade 1. The patient was discharged postoperatively with palpable muscle contractions on both legs, accompanied by no sensory abnormalities. Evaluation 1 month postoperatively, the patient was able to voluntarily move the lower extremities accompanied by the return of ability to micturate and defecate. Examination at 6 months postoperatively, the patient was able to walk without assistance and no other neurological deficit was found. Conclusion: Tumor resection remains as treatment of choice for spinal meningioma regardless of neurological deficit onset and histological type of tumor.
Integrating accounting fintech innovations in the U. S. healthcare sector: opportunities, challenges, and impacts on financial management and patient care
Authors: Olubusola Odeyemi
Published: April 2024

Integrating accounting fintech innovations in the U.S. healthcare sector presents significant opportunities for enhancing financial management and patient care. This paper examines the current landscape of accounting fintech solutions in healthcare, highlighting key opportunities, challenges, and impacts on financial management and patient care. The healthcare industry is increasingly adopting fintech innovations to streamline financial processes, improve efficiency, and enhance patient care. Accounting fintech solutions such as automated billing and payment systems, blockchain technology for secure transactions, and predictive analytics for financial forecasting are revolutionizing financial management practices in healthcare organizations. However, integrating accounting fintech innovations in the healthcare sector also presents several challenges. These include concerns about data security and privacy, the need for regulatory compliance, and the potential for disruption to traditional financial management practices. Addressing these challenges will be crucial to realizing the full potential of accounting fintech in healthcare. The impact of integrating accounting fintech innovations in the U.S. healthcare sector is significant. Improved financial management practices can lead to cost savings, increased revenue, and better resource allocation, ultimately benefiting both healthcare organizations and patients. Additionally, enhanced financial transparency and efficiency can lead to improved patient care outcomes and experiences. In conclusion, integrating accounting fintech innovations in the U.S. healthcare sector offers numerous opportunities for improving financial management and patient care. However, this integration also presents challenges that must be addressed to realize these benefits fully. By overcoming these challenges and leveraging the potential of accounting fintech, healthcare organizations can enhance their financial management practices and provide better care to their patients.
Integrated public health and migration policy: Crafting effective responses to migrant crises
Authors: Ayo Amen Ediae  , Chidinma Favour Chikwe  , Kevin Namiiro Kuteesa
Published: April 2024

The intersection of public health and migration policy presents complex challenges in the context of migrant crises. This abstract provides an overview of the policy analysis on integrated public health and migration policy, focusing on the crafting of effective responses to migrant crises. By examining key findings and implications, it highlights the critical importance of addressing public health needs within migration policy frameworks. The analysis reveals that migrant crises often exacerbate existing public health vulnerabilities, including limited access to healthcare, inadequate sanitation facilities, and heightened risks of infectious diseases. Integrated approaches that prioritize the health needs of migrants are essential for mitigating these challenges and ensuring the well-being of both migrant populations and host communities. Key findings underscore the importance of adopting a comprehensive and rights-based approach to addressing public health in migration policy. This involves recognizing migrants' right to health and ensuring equitable access to healthcare services, regardless of legal status or nationality. Furthermore, it requires addressing the social determinants of health, such as poverty, discrimination, and social exclusion, which disproportionately affect migrant populations. Implications for future research and policy development include the need for greater collaboration and coordination among stakeholders, including government agencies, civil society organizations, and international partners. Research gaps identified underscore the importance of further investigation into the health needs of specific migrant groups, such as refugees, asylum seekers, and undocumented migrants, as well as the effectiveness of different policy interventions in meeting these needs. In conclusion, integrated public health and migration policy is essential for crafting effective responses to migrant crises. By prioritizing the health needs of migrants and adopting a rights-based approach, policymakers can mitigate the negative health impacts of migration and promote the well-being of all individuals affected by migrant crises. This abstract highlights the urgency of addressing public health within migration policy frameworks and calls for greater commitment to integrated approaches that prioritize health equity and human rights.
Empowering youth through sexuality and leadership education: Approaches and outcomes
Authors: Ayo Amen Ediae  , Chidinma Favour Chikwe  , Kevin Namiiro Kuteesa
Published: April 2024

Empowering youth through sexuality and leadership education is crucial for their holistic development and well-being. This paper provides an overview of approaches and outcomes related to empowering youth in these areas. Effective approaches to empowering youth through sexuality and leadership education include comprehensive sexuality education (CSE), youth-friendly services, peer education, and leadership training. CSE equips young people with accurate, age-appropriate information about sexuality, relationships, and reproductive health, enabling them to make informed decisions. Youth-friendly services provide confidential, nonjudgmental health services tailored to young people's needs. Peer education involves young people teaching their peers about sexual and reproductive health, encouraging open dialogue. Leadership training fosters skills such as communication, decision-making, and advocacy, empowering youth to become leaders in their communities. Empowering youth through sexuality and leadership education leads to various positive outcomes. It improves sexual and reproductive health outcomes, including reduced rates of unintended pregnancies, sexually transmitted infections (STIs), and HIV/AIDS. It also promotes gender equality and empowerment, as young people learn about their rights and how to challenge harmful gender norms. Additionally, sexuality and leadership education enhance young people's self-esteem, communication skills, and ability to make informed decisions, preparing them for future leadership roles. Empowering youth through sexuality and leadership education is essential for their development and well-being. By providing comprehensive education and support, we can help young people navigate challenges, make healthy choices, and become empowered leaders in their communities.
General circulation models cannot predict climate
Authors: Michael Jonas
Published: April 2024

This study draws on Chaos Theory to investigate the ability of a General Circulation Model to predict climate. The conclusion is that a General Circulation Model's grid-level physical processes and parameterisations cannot predict climate beyond maybe a few weeks. If a General Circulation Model is to be used at all, longer term climate features can be analysed externally and fed into the model but they cannot be represented by the model any better than by the external analysis. The external analysis, which is likely to be simpler, has the added advantage that the assumptions that are used, and the uncertainties in the results, are much more likely to be explicitly identified, quantified, and understood. Consequently it would be clear which aspects of the climate are being predicted, and how reliable those predictions are. The longer the timescale is, the less relevant the grid-level physical processes and parameterisations in a General Circulation Model become. Although a General Circulation Model can be made to represent climate over a longer time scale, its grid-level physical processes and parameterisations cannot predict the climate. A General Circulation Model calculates weather at each time step and this is then amalgamated into a final prediction of climate. This process is back to front. A realistic long term climate model would calculate climate and then weather would be deduced from the climate.
Comparative technical analysis of legal and ethical frameworks in AI-enhanced procurement processes
Authors: Amaka Justina Obinna  , Azeez Jason Kess-Momoh
Published: April 2024

This study presents a Comparative Technical Analysis of Legal and Ethical Frameworks in AI-Enhanced Procurement Processes. The research aims to evaluate the existing legal and ethical frameworks governing the use of artificial intelligence (AI) in procurement and to identify best practices for ensuring transparency, accountability, and ethical decision-making in AI-driven procurement processes. The study adopts a mixed-methods approach, combining quantitative surveys and qualitative interviews with procurement professionals and legal experts. The research design allows for a comprehensive analysis of the legal and ethical challenges associated with AI deployment in procurement and provides insights into practical strategies for addressing these challenges. Findings from the study indicate a growing recognition of the need for clear guidelines and regulations to govern the use of AI in procurement. While respondents acknowledge the potential benefits of AI, such as improved efficiency and cost savings, they also express concerns about algorithmic bias, data privacy, and the lack of transparency in AI-driven decision-making processes. Based on these findings, the study recommends several strategies for enhancing the legal and ethical frameworks in AI-enhanced procurement processes. These include developing clear guidelines for AI deployment, providing training and support for procurement professionals, and establishing mechanisms for monitoring and evaluating AI systems. Overall, the study highlights the importance of integrating legal and ethical considerations into AI deployment in procurement to ensure transparency, accountability, and ethical decision-making. The findings contribute to the growing body of literature on AI governance and provide practical insights for policymakers, procurement professionals, and other stakeholders involved in AI-driven procurement processes.
Kepraktisan Pengembangan Lembar Kerja Peserta Didik dengan Pendekatan Project Based Learning
Authors: Zusnia Arifah Era , Rahayu Puji
Published: April 2024

Penelitian ini dilatar belakangi dari masih banyak terdapat peserta didik yang kurang untuk berpartisipasi aktif pada proses belajar mengajar karena belum terdapatnya bahan belajar yang bisa mendorong minat dan keaktifan peserta didik. Salah satu cara dalam mendorong aktivitas, minat dan motivasi belajar bagi peserta didik yakni dengan penggunaan LKPD yang mampu menunjang peserta didik aktif serta mandiri selama pembelajaran. Tujuan dari penelitian ini yakni membentuk LKPD dengan pendekatan PJBL pada siswa MTs yang praktis. Research and Development (penelitian pengembangan) digunkan sebagai jenis penelitiannya, dengan model 4D yang memuat tahap Define, Design, Develop, dan Dessiminate. Akan tetapi, dipenelitian ini melakukan tahap Define, Design, serta Develop dengan uji kepratisan saja. Digunakannya lembar observasi keterlaksanaan pembelajaran dan angket respon siswasebagai instrumen penelitian. Hasil penilian kepraktisan LKPD dari presentase keterlaksaan pembelajaran dengan LKPD yakni 94% berkriteria sangat baik. Dan dari hasil angket respon siswa didapatkan rata-rata skor keseluruan yakni 4.38 berkriteria sangat baik. Sehingga bisa diketahui bahwa LKPD dengan pendekatan PJBL pada siswa Mts memenuhi kriteria praktis.
Pengaruh Metode Brainstorming terhadap Kemampuan Berpikir Kritis Siswa Kelas V di SD Inpres Bumi Sagu
Authors: Wahyunisa Sandra Putri , Mufidah Mufidah , Akina Akina , Sani Nurul Kami
Published: April 2024

The ability to think critically about students in Indonesia is relatively low, this is evidenced in the results of the 2018 PISA research survey. Selection of methods is needed to overcome these problems. This study aims to determine the effect of using the Brainstorming method on students' critical thinking skills in fifth grade mathematics at SD Inpres Bumi Sagu. The research design used the One-Group Pretest-Posttest Design with a sample of 18 students in class V B at SD Inpres Bumi Sagu. Data collection used multiple choice questions which included indicators of critical thinking with data analysis using the Paired Sample T-test assisted by the SPSS version 16 program. The results showed an increase in the indicators of knowing and solving problems 47.22; indicators analyze 33.33; indicators evaluate 30.55; and the indicators conclude 18.51. Based on the results of the t-test using the Paired Sample T-test, a sig. (2-tailed) value of 0.000 < 0.05 was obtained. Then the Ha hypothesis is accepted and Ho is rejected, meaning that the brainstorming method in mathematics subject matter of geometric shapes has an effect on the critical thinking skills of fifth grade students of SD Inpres Bumi Sagu.
Analisis Kemampuan Literasi Matematika Siswa Kelas XI Pada Pembelajaran Berbasis Masalah Materi Program Linear
Authors: Karomah Umulluha Hikmatut , Aminudin Mohamad , Kusmaryono Imam
Published: April 2024

Literasi matematika penting untuk siswa dalam meningkatkan cara berpikir logis dan memecahkan masalah dikehidupan sehari-hari. Penelitian ini bertujuan menjelaskan kemampuan literasi matematika siswa pada pembelajaran berbasis masalah materi program linear. Subjek penelitian ini merupakan siswa kelas XI. Metode penelitian yang digunakan yaitu pendekatan deskriptif kualitatif. Data yang didapatkan yaitu data tes tertulis dan wawancara. Teknik pengumpulan data yaitu menggunakan tes, wawancara, serta dokumentasi. Analisis data yaitu menggunakan tahap reduksi data, penyajian data, dan penarikan kesimpulan. Kemampuan literasi matematika siswa kategori tinggi memenuhi semua indikator, kemampuan literasi matematika siswa pada kategori sedang dalam menarik kesimpulan ada kesalahan karena terdapat kekeliruan pada tahap sebelumnya, kemampuan literasi matematika siswa kategori rendah tidak merencanakan penyelesaian masalah dan menerapkan langkah-langkah penyelesaian yang tepat serta tidak mengambil kesimpulan.
Kata Kunci: literasi matematika, pembelajaran berbasis masalah, program linear
Pengaruh Model Pembelajaran Contextual Teaching and Learning terhadap Hasil Belajar Siswa pada Matematika materi Bangun Ruang
Authors: Wahyuni Dian , Mufidah Mufidah , Akina Akina , Nuraini Nuraini
Published: April 2024

This study aims to determine the effect of using the Contextual Teaching and Learning (CTL) learning model on student learning outcomes in mathematics for class V SD Inpres Lawua 1. This research is an experimental study. The research design used was a Quasi Experimental Design with a control group pre-test post-test design. This study used two classes, namely the experimental class and the control class. The sample of this research was the fifth grade students of SD Inpres Lawua 1, which consisted of 25 students. The experimental class consisted of 13 people and the control class consisted of 12 people. Data collection was carried out using an instrument in the form of multiple choice questions, data analysis using the Paired Sample T-test and prerequisite tests, namely the normality test and homogeneity test with the help of the SPSS version 16 program. Based on the results of the t test using the Paire Sample T-test, the sig. (2-tailed) of 0.000 < 0.05. Then the hypothesis Ha is accepted and Ho is rejected, meaning that the CTL learning model on geometric material influences the learning outcomes of fifth grade students at SD Inpres Lawua 1.
Analisis Peran Guru dalam Mengembangkan Sikap Disiplin Siswa SD Islam Darul Huda Genuksari
Authors: Masrur Muhamad , Ismiyanti Yulina , Sari Yunita
Published: April 2024

Guru memiliki peran besar dalam pendidikan peserta didik karena guru dapat melatih kedisiplinan peserta didik disekolah sehingga terbentuklah karakter yang baik dalam diri anak. Guru mempunyai peran yang sangat strategis dalam membentuk pengetahuan, keterampilan, dan karakter peserta didik. Mewujudkan SDM yang mempunyai keterampilan, pengetahuan, dan karakter peserta didik diperlukan sikap disiplin yang baik. Untuk itu, artikel ini bertujuan untuk (1) mengetahui peran guru dalam mengembangkan sikap disiplin siswa, dan (2) Mengetahui sikap disiplin yang dikembangkan pada kelas 3D SD Islam Darul Huda Genuksari. Riset kualitatif ini menggunakan metode analisis dan studi kasus yang bersandar pada observasi, wawancara dan dokumentasi. Hasil penelitian menunjukan (a) peran guru dalam mengembangkan sikap disiplin sudah baik dalam mengajarkan dan membimbing kepada siswa dan terdapat guru mempunyai metode khusus dengan dibiasakan dan membiasakan dalam menerapkan sikap disiplin, (b) guru berperan sebagai suri tauladan dan panutan siswa dengan guru berangkat ke sekolah dengan tepat waktu, tertib dan berpakaian sesuai dengan jadwal, bersikap baik. disiplin dan guru menjaga lisanya dengan baik, (c) sikap disiplin yang dikembangkan yaitu patuh, taat, konsekuen dan tertib. Sikap disiplin yang dikembangkan oleh guru sudah baik dilakukan oleh guru kelas. Hal ini dibuktikan dengan wawancara, observasi dan dokumentasi.
Eskplorasi Etnomatematika dan Filosofi Nilai-Nilai Islam Pada Masjid Agung Kauman Semarang
Authors: Lail Ibnu Jamalul , Wijayanti Dyana , Kusmaryono Imam
Published: April 2024

Etnomatematika merupakan sebuah kajian untuk menjembatani antara budaya kehidupan sehari-hari dengan matematika. Tujuan dalam penelitian ini adalah untuk mengeksplorasi etnomatematika pada Masjid Agung Kauman Semarang.Penelitian ini merupakan penelitian kualitatif dengan pendekatan etnografi. Metode pengumpulan data pada penelitian ini menggunakan observasi, wawancara dan dokumentasi. Teknik analisis data dilakukan terhadap data kualitatif. Hasil penelitian menunjukkan bahwa Konsep-konsep matematika serta filosofi yang terdapat pada bangunan Masjid Agung Kauman Semarang adalah bangun ruang Limas Segiempat pada Atap Masjid Agung Kauman Semarang yang memiliki filosofi bahwa seorang Muslim harus memegang teguh tiga prinsip yaitu Iman, Islam, dan Ihsan serta mustaka yang memilki filosofi bahwa derjat tertinggi manusia adalah Maâ€™rifatullah, bangun ruang Tabung pada Bedug Ijo Mangunsari yang memiliki filosofi bahwa kata Mangunsari berasal dari kata Maâ€™un Syar yang artinya pertolongan dari Allah SWT, bangun datar Persegi panjang serta Konsep Refleksi, Dilatasi dan Translasi pada Pintu Masjid Agung Kauman yang memiliki filosofi sebagai seorang Muslim harus memiliki jiwa sosial yang tinggi dengan membantu sesama dan mempunyai sifat dermawan.Kata Kunci: Etnomatematika, Masjid Agung Kauman Semarang, GeometriÂ AbstractEthnomathematics is a study to bridge the culture of everyday life with mathematics. The purpose of this research is to explore ethnomathematics at the Mosque. This research is qualitative research with an ethnographic approach. Methods of data collection in this study using observation, interviews, and documentation. The data analysis technique was carried out on qualitative data. The results showed that the mathematical concepts and philosophies contained in the building of the Mosque are the building of the Quadrilateral on the roof of the Mosque which has a philosophy that a Muslim must uphold three principles, namely Iman, Islam, and Ihsan and mustaka which have a philosophy that the highest degree of a human being is Ma'rifatullah, build a tube room on the Ijo Mangunsari Bedug which has the philosophy that the word Mangunsari comes from the word Ma'un Syar which means help from Allah SWT, rectangular flat shape and the concept of reflection, dilation, and translation in The door of the Mosque which has a philosophy as a Muslim must have a high social spirit by helping others and have a generous nature.Keywords: Ethnomatehmatics, Masjid Agung Kauman Semarang, Geometry