bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 4 from Long-term Sculpting of the B-cell Repertoire following Cancer Immunotherapy in Patients Treated with Sipuleucel-T
Authors: Zhang Li , Kandadi Harini , Yang Hai , Cham Jason , He Tao , Oh David Y. , Sheikh Nadeem A. , Fong Lawrence
Published: April 2023

Supplementary Fig. 4: (A-D) BCR convergent groups converge to shared amino acid sequences. (A-B) Phylogenetic trees across all repertories of a representative naive patient (A) and of a representative treated patient (B). For each patient, social network analysis was performed using R packages: Ape (24) and igraph (25). A convergent group was defined as a cluster that includes the clones with the distance less than or equal to 1 (allowing maximum of 1 basepair mutation among clone sequences sharing the same V-gene, J-gene and CDR3 length). The phylogenetic tree was plotted by R package: ggtree (26) with the edge color was coded by amino acid sequences. (C) Social network of a selected V family (V01) across all repertories from the 6 time points of the representative treated patient. Each node represents a single full-length of BCR clonotype sequence colored by its corresponding CDR3 amino acid sequences; node size was characterized based on the corresponding abundance. The nodes connected by lines were within the same convergent group. (D) Social network figures of top 6 largest groups in the V01 family across all repertories from the 6 time points of the representative treated patient in (C). One convergent group was selected for illustration purpose with presenting the actual converged two CDR3 amino acid sequences. (E) Public clusters shared by treated patients at baseline and naïve patients post baseline. Across all repertories from treated patients at baseline and naïve patients post baseline, 5 public clones were identified first. Then social network analysis was performed to find the clones which were at most 1 basepair mismatch with those 5 public clones.
Supplementary Figure 3 from Long-term Sculpting of the B-cell Repertoire following Cancer Immunotherapy in Patients Treated with Sipuleucel-T
Authors: Zhang Li , Kandadi Harini , Yang Hai , Cham Jason , He Tao , Oh David Y. , Sheikh Nadeem A. , Fong Lawrence
Published: April 2023

Selected convergent groups. (A) Illustration of the groups that are persistently present across all time points for the treated patient. (B) Illustration of the groups induced in the treated patient. (C) Illustration of the induced groups in the naive patient. Each figure includes the actual nucleotide sequences corresponding to Fig 3E-3G. The colors were coded by ACTG (only first 60 base-pairs were retained due to space limitations). The yellow highlighting shows the hypermutation in the nucleotide sequence, while the bottom row shows the motif analysis. The tables present the clonal abundance for corresponding clones each time point.
Figure S3 from Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development
Authors: Gui Xun , Deng Mi , Song Hao , Chen Yuanzhi , Xie Jingjing , Li Zunling , He Licai , Huang Fangfang , Xu Yixiang , Anami Yasuaki , Yu Hai , Yu Chenyi , Li Leike , Yuan Zihao , Xu Xiaoying , Wang Qihui , Chai Yan , Huang Tao , Shi Yi , Tsuchikama Kyoji , Liao X. Charlene , Xia Ningshao , Gao George F. , Zhang Ningyan , Zhang Cheng Cheng , An Zhiqiang
Published: April 2023

Schematic diagram of the LILRB4 chimeric receptor reporter system.
Supplementary Figure 1 from Long-term Sculpting of the B-cell Repertoire following Cancer Immunotherapy in Patients Treated with Sipuleucel-T
Authors: Zhang Li , Kandadi Harini , Yang Hai , Cham Jason , He Tao , Oh David Y. , Sheikh Nadeem A. , Fong Lawrence
Published: April 2023

Study Schema. The top panel is the study schema for P101 study (treated patients) and the bottom panel is for the STRIDE study schema (naïve patients). As shown in the figure, the treated patients had received sipuleucel-T treatment on average of 8.9 years ago before joined P10-1 study. For both studies, the patients had 3 infusions every 2 weeks (week 0, week 2 and week 4). The baseline was indicated as in the figure, which was right before the 1st infusion. The blood samples were collected at week 0, week 2 and week 4 right before each infusion, as well as at week 6, week 26 and week 52. Both studies have long term follow-up after one year.
Supplementary Figures from Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype
Authors: Jaiswal Ashvin R. , Liu Arthur J. , Pudakalakatti Shivanand , Dutta Prasanta , Jayaprakash Priyamvada , Bartkowiak Todd , Ager Casey R. , Wang Zhi-Qiang , Reuben Alexandre , Cooper Zachary A. , Ivan Cristina , Ju Zhenlin , Nwajei Felix , Wang Jing , Davies Michael A. , Davis R. Eric , Wargo Jennifer A. , Bhattacharya Pratip K. , Hong David S. , Curran Michael A.
Published: April 2023

Supplementary Figures 1-9
Supplementary Figure Legends from DGKA Mediates Resistance to PD-1 Blockade
Authors: Fu Lingyi , Li Sen , Xiao WeiWei , Yu Kuai , Li Shuo , Yuan Sujing , Shen Jianfei , Dong Xingjun , Fang Ziqian , Zhang Jianeng , Chen Siyu , Li Wende , You Hua , Xia Xiaojun , Kang Tiebang , Tan Jing , Chen Gong , Yang An-Kui , Gao YuanHong , Zhou Penghui
Published: April 2023

Supplementary Figure Legends S1-S6
Supplementary Figure 6 from DGKA Mediates Resistance to PD-1 Blockade
Authors: Fu Lingyi , Li Sen , Xiao WeiWei , Yu Kuai , Li Shuo , Yuan Sujing , Shen Jianfei , Dong Xingjun , Fang Ziqian , Zhang Jianeng , Chen Siyu , Li Wende , You Hua , Xia Xiaojun , Kang Tiebang , Tan Jing , Chen Gong , Yang An-Kui , Gao YuanHong , Zhou Penghui
Published: April 2023

Supplementary Figure 6
Supplementary Figure 3 from DGKA Mediates Resistance to PD-1 Blockade
Authors: Fu Lingyi , Li Sen , Xiao WeiWei , Yu Kuai , Li Shuo , Yuan Sujing , Shen Jianfei , Dong Xingjun , Fang Ziqian , Zhang Jianeng , Chen Siyu , Li Wende , You Hua , Xia Xiaojun , Kang Tiebang , Tan Jing , Chen Gong , Yang An-Kui , Gao YuanHong , Zhou Penghui
Published: April 2023

Supplementary Figure 3
Supplementary Figure 2 from DGKA Mediates Resistance to PD-1 Blockade
Authors: Fu Lingyi , Li Sen , Xiao WeiWei , Yu Kuai , Li Shuo , Yuan Sujing , Shen Jianfei , Dong Xingjun , Fang Ziqian , Zhang Jianeng , Chen Siyu , Li Wende , You Hua , Xia Xiaojun , Kang Tiebang , Tan Jing , Chen Gong , Yang An-Kui , Gao YuanHong , Zhou Penghui
Published: April 2023

Supplementary Figure 2
Supplementary Figures 1-7 from A PSMA-Targeting CD3 Bispecific Antibody Induces Antitumor Responses that Are Enhanced by 4-1BB Costimulation
Authors: Chiu Danica , Tavaré Richard , Haber Lauric , Aina Olulanu H. , Vazzana Kristin , Ram Priyanka , Danton Makenzie , Finney Jennifer , Jalal Sumreen , Krueger Pamela , Giurleo Jason T. , Ma Dangshe , Smith Eric , Thurston Gavin , Kirshner Jessica R. , Crawford Alison
Published: April 2023

Supplementary figures
Supplementary Figure 6 from The Expression of Adenosine A2B Receptor on Antigen-Presenting Cells Suppresses CD8+ T-cell Responses and Promotes Tumor Growth
Authors: Chen Siqi , Akdemir Imran , Fan Jie , Linden Joel , Zhang Bin , Cekic Caglar
Published: April 2023

Supplementary Figure 6
Supplementary Figure 4 from The Expression of Adenosine A2B Receptor on Antigen-Presenting Cells Suppresses CD8+ T-cell Responses and Promotes Tumor Growth
Authors: Chen Siqi , Akdemir Imran , Fan Jie , Linden Joel , Zhang Bin , Cekic Caglar
Published: April 2023

Supplementary Figure 4
Supplementary Tables and Figures from Hijacking TYRO3 from Tumor Cells via Trogocytosis Enhances NK-cell Effector Functions and Proliferation
Authors: Lu Ting , Ma Rui , Li Zhenlong , Mansour Anthony G. , Teng Kun-Yu , Chen Li , Zhang Jianying , Barr Tasha , Caligiuri Michael A. , Yu Jianhua
Published: April 2023

Supplementary Tables S1-S2 and Supplementary Figures S1-S5
Supplementary Table S1 from Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity
Authors: Sakemura Reona , Bansal Aditya , Siegler Elizabeth L. , Hefazi Mehrdad , Yang Nan , Khadka Roman H. , Newsom Alysha N. , Hansen Michael J. , Cox Michelle J. , Manriquez Roman Claudia , Schick Kendall J. , Can Ismail , Tapper Erin E. , Nevala Wendy K. , Adada Mohamad M. , Bezerra Evandro D. , Kankeu Fonkoua Lionel Aurelien , Horvei Paulina , Ruff Michael W. , Parikh Sameer A. , Pandey Mukesh K. , DeGrado Timothy R. , Suksanpaisan Lukkana , Kay Neil E. , Peng Kah-Whye , Russell Stephen J. , Kenderian Saad S.
Published: April 2023

Supplementary Table S1
Supplementary Figures from Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity
Authors: Sakemura Reona , Bansal Aditya , Siegler Elizabeth L. , Hefazi Mehrdad , Yang Nan , Khadka Roman H. , Newsom Alysha N. , Hansen Michael J. , Cox Michelle J. , Manriquez Roman Claudia , Schick Kendall J. , Can Ismail , Tapper Erin E. , Nevala Wendy K. , Adada Mohamad M. , Bezerra Evandro D. , Kankeu Fonkoua Lionel Aurelien , Horvei Paulina , Ruff Michael W. , Parikh Sameer A. , Pandey Mukesh K. , DeGrado Timothy R. , Suksanpaisan Lukkana , Kay Neil E. , Peng Kah-Whye , Russell Stephen J. , Kenderian Saad S.
Published: April 2023

Supplementary Figures and Legends
Supplementary Figures and Legends from Histone Deacetylase Inhibitors and IL21 Cooperate to Reprogram Human Effector CD8+ T Cells to Memory T Cells
Authors: Wang Junmei , Hasan Farah , Frey Amanda C. , Li Haiyan S. , Park Jungsun , Pan Ke , Haymaker Cara , Bernatchez Chantale , Lee Dean A. , Watowich Stephanie S. , Yee Cassian
Published: April 2023

Supplementary Figures and Legends
Supplementary Figure from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor Microenvironment
Authors: Sidiropoulos Dimitrios N. , Rafie Christine I. , Jang Julie K. , Castanon Sofi , Baugh Aaron G. , Gonzalez Edgar , Christmas Brian J. , Narumi Valerie H. , Davis-Marcisak Emily F. , Sharma Gaurav , Bigelow Emma , Vaghasia Ajay , Gupta Anuj , Skaist Alyza , Considine Michael , Wheelan Sarah J. , Ganesan Sathish Kumar , Yu Min , Yegnasubramanian Srinivasan , Stearns Vered , Connolly Roisin M. , Gaykalova Daria A. , Kagohara Luciane T. , Jaffee Elizabeth M. , Fertig Elana J. , Roussos Torres Evanthia T.
Published: April 2023

Supplementary Figure from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor Microenvironment
Figure S2 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity
Authors: Zhang Youhua , Xie Ruting , Zhang Hailong , Zheng Yajuan , Lin Changdong , Yang Lei , Huang Mengwen , Li Man , Song Feifei , Lu Ling , Yang Muqing , Liu Ying , Wei Qing , Li Jiyu , Chen Jianfeng
Published: April 2023

The association between ITGB7 expression and survival, CMS types, and stages of CRC.
Figure S1 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity
Authors: Zhang Youhua , Xie Ruting , Zhang Hailong , Zheng Yajuan , Lin Changdong , Yang Lei , Huang Mengwen , Li Man , Song Feifei , Lu Ling , Yang Muqing , Liu Ying , Wei Qing , Li Jiyu , Chen Jianfeng
Published: April 2023

Immune cell infiltration in tumor and adjacent normal tissues from CRC patients.
Data from Optimization of Peptide Vaccines to Induce Robust Antitumor CD4 T-cell Responses
Authors: Kumai Takumi , Lee Sujin , Cho Hyun-Il , Sultan Hussein , Kobayashi Hiroya , Harabuchi Yasuaki , Celis Esteban
Published: April 2023

Abstract
Substantial evidence indicates that immunotherapy is a feasible and effective approach for the treatment of numerous types of cancer. Among various immunotherapy options, peptide vaccines to generate antitumor T cells appear as promising candidates, because of their cost effectiveness and ease of implementation. Nevertheless, most peptide vaccines are notorious for being weekly immunogenic and, thus, optimization of the vaccination strategy is essential to achieve therapeutic effectiveness. In addition, effective peptide vaccines must stimulate both CD8 cytotoxic and CD4 helper T lymphocytes. Our group has been successful in designing effective peptide vaccination strategies for inducing CD8 T-cell responses in mouse tumor models. Here, we describe a somewhat similar, but distinct, peptide vaccination strategy capable of generating vast CD4 T-cell responses by combining synthetic peptides with toll-like receptor (TLR) agonists and OX40/CD40 costimulation. This vaccination strategy was efficient in overcoming immune tolerance to a self-tumor–associated antigen and generated significant antitumor effects in a mouse model of malignant melanoma. The optimized peptide vaccine also allowed the expansion of adoptively transferred CD4 T cells without the need for lymphodepletion and IL2 administration, generating effective antimelanoma responses through the enhancement of proliferative and antiapoptotic activities of CD4 T cells. These results have practical implications in the design of more effective T-cell–based immunotherapies. Cancer Immunol Res; 5(1); 72–83. ©2016 AACR.
Supplementary figures merged from Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
Authors: Xie Stephanie Z. , Kaufmann Kerstin B. , Wang Weijia , Chan-Seng-Yue Michelle , Gan Olga I. , Laurenti Elisa , Garcia-Prat Laura , Takayanagi Shin-ichiro , Ng Stanley W.K. , Xu ChangJiang , Zeng Andy G.X. , Jin Liqing , McLeod Jessica , Wagenblast Elvin , Mitchell Amanda , Kennedy James A. , Liu Qiang , Boutzen Héléna , Kleinau Melissa , Jargstorf Joseph , Holmes Gareth , Zhang Yang , Voisin Veronique , Bader Gary D. , Wang Jean C.Y. , Hannun Yusuf A. , Luberto Chiara , Schroeder Timm , Minden Mark D. , Dick John E.
Published: April 2023

Figure S1 to S10
Figure S6 from Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy
Authors: Kretzmer Helene , Biran Anat , Purroy Noelia , Lemvigh Camilla K. , Clement Kendell , Gruber Michaela , Gu Hongcang , Rassenti Laura , Mohammad Arman W. , Lesnick Connie , Slager Susan L. , Braggio Esteban , Shanafelt Tait D. , Kay Neil E. , Fernandes Stacey M. , Brown Jennifer R. , Wang Lili , Li Shuqiang , Livak Kenneth J. , Neuberg Donna S. , Klages Sven , Timmermann Bernd , Kipps Thomas J. , Campo Elias , Gnirke Andreas , Wu Catherine J. , Meissner Alexander
Published: April 2023

DMR methylation in MBL and CLL sampl
Figure S11 from Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G1–S Cell-Cycle Transition
Authors: Zhang Jingwei , Pearson Adam J. , Sabherwal Nitin , Telfer Brian A. , Ali Nisha , Kan Karmern , Xu Qiuping , Zhang Wei , Chen Fuhui , Li Shiyang , Wang Jinhua , Gray Nathanael S. , Risa-Ebrí Blanca , Finegan Katherine G. , Cross Michael J. , Giurisato Emanuele , Whitmarsh Alan J. , Tournier Cathy
Published: April 2023

Combined ERK5 silencing plus lapatinib treatment caused a greater reduction in the percentage of breast cancer cells in S phase compared with lapatinib alone.
Figure S1 from Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G1–S Cell-Cycle Transition
Authors: Zhang Jingwei , Pearson Adam J. , Sabherwal Nitin , Telfer Brian A. , Ali Nisha , Kan Karmern , Xu Qiuping , Zhang Wei , Chen Fuhui , Li Shiyang , Wang Jinhua , Gray Nathanael S. , Risa-Ebrí Blanca , Finegan Katherine G. , Cross Michael J. , Giurisato Emanuele , Whitmarsh Alan J. , Tournier Cathy
Published: April 2023

Kaplan-Meier analyses of human HER2+ breast cancer samples show that no predictive outcome can be established from ERK1 or ERK2 expression levels.
Data from The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models
Authors: Brinch Shoshy A. , Amundsen-Isaksen Enya , Espada Sandra , Hammarström Clara , Aizenshtadt Aleksandra , Olsen Petter A. , Holmen Lone , Høyem Merete , Scholz Hanne , Grødeland Gunnveig , Sowa Sven T. , Galera-Prat Albert , Lehtiö Lari , Meerts Ilonka A.T.M. , Leenders Ruben G.G. , Wegert Anita , Krauss Stefan , Waaler Jo
Published: April 2023

The catalytic enzymes tankyrase 1 and 2 (TNKS1/2) alter protein turnover by poly-ADP-ribosylating target proteins, which earmark them for degradation by the ubiquitin–proteasomal system. Prominent targets of the catalytic activity of TNKS1/2 include AXIN proteins, resulting in TNKS1/2 being attractive biotargets for addressing of oncogenic WNT/β-catenin signaling. Although several potent small molecules have been developed to inhibit TNKS1/2, there are currently no TNKS1/2 inhibitors available in clinical practice. The development of tankyrase inhibitors has mainly been disadvantaged by concerns over biotarget-dependent intestinal toxicity and a deficient therapeutic window. Here we show that the novel, potent, and selective 1,2,4-triazole–based TNKS1/2 inhibitor OM-153 reduces WNT/β-catenin signaling and tumor progression in COLO 320DM colon carcinoma xenografts upon oral administration of 0.33–10 mg/kg twice daily. In addition, OM-153 potentiates anti–programmed cell death protein 1 (anti–PD-1) immune checkpoint inhibition and antitumor effect in a B16-F10 mouse melanoma model. A 28-day repeated dose mouse toxicity study documents body weight loss, intestinal damage, and tubular damage in the kidney after oral–twice daily administration of 100 mg/kg. In contrast, mice treated oral–twice daily with 10 mg/kg show an intact intestinal architecture and no atypical histopathologic changes in other organs. In addition, clinical biochemistry and hematologic analyses do not identify changes indicating substantial toxicity. The results demonstrate OM-153–mediated antitumor effects and a therapeutic window in a colon carcinoma mouse model ranging from 0.33 to at least 10 mg/kg, and provide a framework for using OM-153 for further preclinical evaluations.
Significance:
This study uncovers the effectiveness and therapeutic window for a novel tankyrase inhibitor in mouse tumor models.
Data from Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy–induced Metastasis
Authors: Hoskin Victoria , Ghaffari Abdi , Laight Brian J. , SenGupta Sandip , Madarnas Yolanda , Nicol Christopher J.B. , Elliott Bruce E. , Varma Sonal , Greer Peter A.
Published: April 2023

The main cause of cancer-associated deaths is the spread of cancer cells to distant organs. Despite its success in the primary tumor setting, modern chemotherapeutic strategies are rendered ineffective at treating metastatic disease, largely due to the development of resistance. The adaptor protein ezrin has been shown to promote cancer metastasis in multiple preclinical models and is associated with poor prognosis in several cancer types, including breast cancer. Ezrin promotes pro-survival signaling, particularly in disseminated cancer cells, to facilitate metastatic outgrowth. However, the role of ezrin in breast cancer chemoresistance is not fully known. In this study, we show that upregulating or downregulating ezrin expression modifies the sensitivity of breast cancer cells to doxorubicin and docetaxel treatment in vitro and is associated with changes in PI3K/Akt and NFκB pathway activation. In addition, we tested the effects of systemic treatment with a small-molecule ezrin inhibitor, NSC668394, on lung metastatic burden in vivo as a monotherapy, or in combination with anthracycline- or taxane-based chemotherapy treatment. We show that anti-ezrin treatment alone reduces metastatic burden and markedly sensitizes metastases to doxorubicin or docetaxel in neoadjuvant as well as neoadjuvant plus adjuvant treatment models. Taken together, our findings demonstrate the impact of anti-ezrin treatment in modulating response to chemotherapy in breast cancer cells as well as the efficacy of anti-ezrin treatment in combination with chemotherapy at reducing metastatic burden.
Significance:
This work provides preclinical evidence for combining anti-ezrin treatment with chemotherapy as a novel strategy for effectively targeting metastasis, particularly in a neoadjuvant treatment setting.
Weekly Growth Hormone (Lonapegsomatropin) Causes Severe Transient Hyperglycemia in a Child with Obesity
Authors: Alkhatib Einas H. , Dauber Andrew , Estrada Doris Elizabeth , Majidi Shideh
Published: April 2023

Introduction: A 12-year-and-9-month-old non-Hispanic black male with a history of growth hormone deficiency, pituitary hypoplasia, prediabetes, obesity, hypertension, and hyperlipidemia was initiated on weekly growth hormone (lonapegsomatropin-tcgd) and then transiently developed symptomatic hyperglycemia to 500 mg/dL. We aimed to describe this medication’s effect. Case Presentation: He was born full term and appropriate for gestational age. He was referred to endocrinology at 3.5 years of age for short stature with a height SDS of −2.48. IGF-1 51.1 ng/mL and IGFBP-3 1.2 ng/mL were low. GH stimulation test noted baseline and peak GH of 0.1 ng/mL. MRI brain showed hypoplastic adenohypophysis, aplastic pituitary stalk, and ectopic neurohypophysis. There had been difficulty with adherence to daily GH over the following 9 years. BMI trajectory rose above 180% of the 95th percentile. By age 12, A1c was 6.6%. Metformin was started and increased to 1,000 mg twice daily. Subsequent A1c was 6.0%. Due to poor compliance with daily GH, at 12 years and 9 months, he was initiated on 22 mg (0.25 mg/kg/week) of weekly lonapegsomatropin-tcgd to improve compliance. The day after his first injection, he developed non-bloody, non-bilious emesis. He denied headaches and endorsed polyuria. Due to concern for increased intracranial pressure, he was sent to the emergency department; however, ophthalmologic exam was negative. Initial serum glucose was 500 mg/dL, then 336 mg/dL after 1-L normal saline. Hemoglobin A1c was 5.7%, urine glucose 3+ mg/dL, and urine ketones 2+ mg/dL. Venous pH of 7.379 and bicarbonate of 20.6 mmol/L ruled out diabetic ketoacidosis. Metformin was held during the hospitalization. Hyperglycemia rapidly improved with transient insulin administration. He received one dose of glargine 20 units. He was initiated on lispro carb ratio of 1:8 and correction factor 1:15 for target glucose 150 mg/dL. By day four, glucoses were below 100 mg/dL; lispro was discontinued, and he was discharged home. Weekly GH was discontinued with plans to resume daily GH therapy in several months. Conclusion: Lonapegsomatropin-tcgd offers the convenience of weekly rather than daily GH treatment; however, this patient developed a rapid increase in insulin resistance and hyperglycemia requiring insulin. The discrepancy between the glucose of 500 mg/dL and A1c of 5.7%, along with the rapid resolution of hyperglycemia, is further consistent with a medication side effect. Close glucose monitoring of patients initiated on weekly growth hormone is crucial, particularly in those with a history of prediabetes.
What do Science Teachers Notice in the K12 Learner’s Material Produced by State Education Department?
Authors: Alagadan Marc Engelbert R. , Rogayan Jr Danilo V. , Dacayo Jonalyn C.
Published: April 2023

Learning materials aid conceptual retention, stir learning motivation, increase academic engagement, and enhance student achievement. This study is a descriptive-evaluative research that described the science teachers’ assessment of the Grade 8 Science K12 learner’s material produced by the state education department. The study was conducted in three government-owned secondary schools in Zambales, Philippines. The science teachers used a modified Learning Resource Assessment Tool developed by Prince Edward Island (2008) in evaluating the K12 material. Results revealed that the learner’s material is satisfactory in terms of content, instructional design, and technical design. However, the teachers cited some problems encountered, such as inadequacy of the materials for the learners, the incongruence of the topics to the learning competencies, and lack of instructional time to cover all the topics. The teachers also laid some recommendations that can be forwarded to the Department of Education to review, refine, revise and re-align the learner’s material to make it research-based, relevant, and responsive to the learners' needs.
Purchase and Collection Motivations of Co-Branded Limited-Edition Collectibles: The case of the Jollibee Funko Pop
Authors: Santos Joseph Emil , Vergara Raymond Allan G.
Published: April 2023

This exploratory case study seeks to understand the purchase and collection motivations of an international co-branded limited-edition collectible. It also explores consumers’ perceptions of the brand collaboration between Philippine-based Jollibee and United States-based Funko. This study finds that consumers are motivated to purchase and collect products based on their willingness to identify with the brand, which stems from personal values, self-concept, and nostalgia. While most studies on co-branding use simulated alliances, this study provides a real example of an international branding collaboration, thereby providing a nuanced understanding of co-branding spillover effects and how a consumer’s willingness to identify with a brand motivates their purchase and collection decisions.
EFL Learners in Thailand: Content Analysis of Research Articles
Authors: Maravilla Wes Harven G. , Maming Jimmy Bernabe
Published: April 2023

Due to recent shifts in the laws regulating Thailand's educational system, more study has been done on teaching English to EFL Thai pupils. Finding the frequent distribution of these studies in terms of their topics, publication years, writers, groups, and research methods is the main objective of this study. 56 articles were selected as the sample because it was discovered that they were content-specific in the context of English Language Acquisition in Thailand. Data was collected using the Article Information Rubric, and it was processed using Microsoft Excel. The following are the study's major conclusions:

"Methods and Strategies" is the subject of most articles written by ELT scholars.

The frequent distribution of publication years has changed significantly.

The majority of college students were chosen as the group using the random selection technique.

Mixed study techniques were used in the majority of the investigations.

Questionnaires and conversations were used by researchers to gather data.

The most frequently used form of data analysis in these studies is frequency and proportion charts.
Basic Education Learning Continuity Plan (BE-LCP) Implementation: Challenges and Opportunities
Authors: Sabacajan Bazil T. , Moradods Alexander N.
Published: April 2023

The Basic Education Learning Continuity Plan (BE-LCP) was developed collaboratively by the Philippines through the Department of Education) in response to the need to continue education despite the restrictions imposed by the COVID-19 crisis. This is to ensure that education is delivered without jeopardizing the health and safety of its learners and employees. Therefore, this current study aims to determine the level of awareness and the extent of challenges and opportunities in implementing the Basic Education Learning Continuity Plan. The study was mainly quantitative by design and used the survey questionnaire and interview method to gather the necessary information. The survey questionnaire served as primary data from respondents' responses on the awareness, challenges, and opportunities of BE- LCP implementation.   The result of the study indicates that the overall level of BE-LCP awareness was placed at a moderate extent, the overall extent of challenges among the respondents was penned moderate, and the overall extent of opportunities on the implementation of the BE-LCP was also moderate. Furthermore, there was a significant difference in the level of awareness on the BE-LCP implementation among the teachers, stakeholders, and students, meanwhile, the study reveals that there was no significant relationship among the variables of the study. As a result, the Division of Camiguin intends to ensure BE-LCP implementation and deliver quality education in the new normal.
“Project TUBIG PARA SA LAHAT (Water for All)”: A Community Based Action Research
Authors: Asio John Mark R. , Gadia Ediric D. , Cura Carlmaulen J. , Soriano Imelda DP.
Published: April 2023

This paper aims to present the community extension project of local higher education in Olongapo City, Philippines. The project entitled “Project Tubig Para sa Lahat (Water for All).” is a collaborative effort of the Gordon College – Community Extension Service Unit (GC –CESU) and different Non-Government Organizations (NGOs). The project's main objective is to provide a clean water storage for every household in a far-flung community in Olongapo City. This project is an initial step towards the United Nations Sustainable Development Goals (UN SDGs) mandate, in particular SDG 6. After a series of meetings, a strategic planning, and months of preparation, the project commenced. However, there were some challenges in the logistics due to the distance and terrain of the place. Nevertheless, the project was successful and turned over to the community as a sign of community engagement to all parties involved. The whole community has full access to the water tank project, and many households benefitted from the said project.
Lack of refuge as a bottleneck for reptiles in intensive woody crops
Authors: Canós-Burguete Marta , Torrijo-Salesa Mizar , Tortosa Francisco S. , Guerrero-Casado José
Published: April 2023

The lack of refuge has been suggested as one of the main factors affecting reptiles in intensive crops, but this theory has not been explored to any great extent. The aim of this work is to compare the reptile abundance and species richness between traditional and intensive vineyards and olive groves, and to test the acceptance of artificial shelter due to its scarcity in the new intensive woody crop. A total of 288 transects were carried out (144 in olive groves and 144 in vineyards) in six different types of plots: traditional olive groves, traditional vineyards, intensive olive groves with and without artificial refuge, and trellis vineyards with and without artificial refuge. The results showed a greater species richness and abundance of reptiles in the traditional plots than in the intensive plots (independently of the experimental refuges added). An important number of animals were observed using the artificial refuges in olive groves. Furthermore, most of the individuals were located on or escaped to old trees in traditional systems, including an important proportion of reptiles hidden in olive trunk cavities, whereas more individuals were observed on the ground in intensive systems. Our finding suggests the importance for reptile communities of the traditional agricultural systems due to the high availability of the refuge provided by old olive tree trunks and free-standing gobelet vineyards. Our results show that providing refuge may mitigate the negative effects of woody crops intensification on reptile communities.
The Scaling Down of SAGCOT Public Private Partnerships
Authors: Pauline Noah M. , Mbande Victor , Börjeson Lowe
Published: April 2023

This study analyses SAGCOT’s public-private partnership policy, which anticipated attracting external investors in large-scale nucleus farms to commercialise smallholder farmers. Data were collected from a review of SAGCOT policy documents, a compilation of SAGCOT registered partners and qualitative interview data collected from private companies, government officials, farmers and outgrower associations. The majority of SAGCOT registered commercial partners are small- to medium-scale and most of them were already operating in the area before SAGCOT was established. We conclude that the SAGCOT investment strategy, in practice, has been linked to small- to medium-scale operations and also mainly to already existing enterprises, which stand in contrast to the initially envisioned model of attracting new large-scale farming enterprises to the region. We argue that there is a need for SAGCOT and policy makers to learn from this dissonance between initial policy ambition and actual outcomes of SAGCOT public-private partnerships.
On the possible functions of helical thickenings in conductive cells in wood
Authors: Costa Adriana , Wiedenhoeft Alex C.
Published: April 2023

The career of Sherwin J. Carlquist was marked by numerous pioneering contributions to botany and especially to ecological and evolutionary wood anatomy. He developed some of the most important modern functional hypotheses for wood, including postulating a biomechanical and fluid dynamic role for helical thickenings (HT) in seasonally dry environments. Here we endeavor to honor Carlquist’s legacy by summarizing existing observations, explicitly acknowledging that HT represent a range of non-homologous and likely functionally disparate features, and exploring HT functional hypotheses in light of data from a pantropical genus, Croton, in which HT are associated with mesic rather than xeric conditions. This is noteworthy in part because HT are commonly associated with the flora of temperate mesic areas and seasonally dry areas, particularly in non-tropical regions. Based on observations in Croton, the distribution of HT around the world, and interesting advances in fluid dynamics, we propose that diversity in this feature may serve two related functions in addition to the potential mechanical role previously articulated, namely, vessel refilling after cavitation and increased hydraulic efficiency.
Ophiopogon muongnhensis (Asparagaceae, Convallarioideae), a new species from northwest Vietnam
Authors: PHAM VAN THE , TANAKA NORIYUKI , AVERYANOV LEONID V. , MAISAK TATIANA V. , TRAN HUY THAI , NGUYEN HUU CUONG , NGUYEN KHANG SINH
Published: April 2023

Ophiopogon muongnhensis, a new species from Dien Bien Province, NW Vietnam, is described and illustrated. In having slenderly petioled clavate leaves it is most similar to O. griffithii originally described from NE India, but clearly distinguishable mainly by its wider (1.8–2.9 vs. 0.3–1.9 cm) leaf blades, wider (3.5–7.5 vs. 2–2.8 mm), obliquely (vs. explanately) expanded perianth lobes, and free narrowly deltoid (vs. laterally connate, linear-lanceolate) anthers. Notes on the habitat, conservation status, phenology, and taxonomic relationships with congeners were also provided.
Time Series Optimal Capacity Determination Model of Regional Comprehensive Energy Considering Multi Energy Complementarity and Load Flexibility
Authors: Huang Guangzheng
Published: April 2023

In order to improve the voltage stability margin and convergence speed of the power grid, a regional comprehensive energy time series optimization capacity model is established under the condition of fully considering the multi energy complementarity and load flexibility. The multi energy complementary optimal operation model of regional comprehensive energy system is established, the load flexibility and multi energy complementary characteristics are analyzed, and the robust optimal capacity target of regional comprehensive energy system is set on the basis of considering the load flexibility. From the perspective of time series, an optimized capacity model is constructed, and genetic algorithm is improved to solve the multi-objective optimization model of regional comprehensive energy time series capacity. The experimental results show that this method has good optimization effect, improves the stability margin and convergence speed of power grid voltage, and can find the optimal solution for the established objective function, which effectively improves the effect of capacity determination.
Deciphering the Trend and Interannual Variability of Temperature and Precipitation Extremes over Greenland during 1958–2019
Authors: Wei Ting , Zhao Shoudong , Noël Brice , Yan Qing , Qi Wei
Published: April 2023

Greenland experienced multiple extreme weather/climate events in recent decades that led to significant melting of the ice sheet. However, how the intensity of extreme climate events over Greenland varied under recent warming has not been fully examined. Here, we collect 176 in situ observations over Greenland and demonstrate that the observed extreme temperature/precipitation events over Greenland are well captured by the RACMO2.3p2 model, in terms of climatological distribution, interannual variability, and long-term trend. Thus, we then investigate the spatiotemporal features of extreme events over Greenland during 1958–2019, using the daily model outputs at 5.5-km resolution. The simulated annual maximum temperature exhibits a significant increasing trend (∼0.13°C decade−1) during 1958–2019, whereas there is a weakening trend (−0.24°C decade−1) in annual minimum temperature over Greenland, especially after the 1990s (−1.24°C decade−1). For the interannual variability, changes in temperature extremes between warm and cold temperature years share large similarities with the distributions of long-term trends. The extreme precipitation events measured by annual maximum daily precipitation amount show a profound increasing trend (0.52 mm day−1 decade−1) over northeastern Greenland during 1958–2019, with large interannual variability in the ice-free coastal region and southern Greenland. Additionally, the changes in extreme warm and cold events are generally linked with the variation of Greenland blocking in summer and Arctic polar vortex in winter, respectively, in terms of favorable circulation background, and the extreme precipitation events are often associated with the position of the polar jet stream.
Using the U.S. Climate Reference Network to Identify Biases in Near- and Subsurface Meteorological Fields in the High-Resolution Rapid Refresh (HRRR) Weather Prediction Model
Authors: Lee Temple R. , Leeper Ronald D. , Wilson Tim , Diamond Howard J. , Meyers Tilden P. , Turner David D.
Published: April 2023

The ability of high-resolution mesoscale models to simulate near-surface and subsurface meteorological processes is critical for representing land–atmosphere feedback processes. The High-Resolution Rapid Refresh (HRRR) model is a 3-km numerical weather prediction model that has been used operationally since 2014. In this study, we evaluated the HRRR over the contiguous United States from 1 January 2021 to 31 December 2021. We compared the 1-, 3-, 6-, 12-, 18-, 24-, 30-, and 48-h forecasts against observations of air and surface temperature, shortwave radiation, and soil temperature and moisture from the 114 stations of the U.S. Climate Reference Network (USCRN) and evaluated the HRRR’s performance for different geographic regions and land cover types. We found that the HRRR well simulated air and surface temperatures, but underestimated soil temperatures when temperatures were subfreezing. The HRRR had the largest overestimates in shortwave radiation under cloudy skies, and there was a positive relationship between the shortwave radiation mean bias error (MBE) and air temperature MBE that was stronger in summer than winter. Additionally, the HRRR underestimated soil moisture when the values exceeded about 0.2 m3 m−3, but overestimated soil moisture when measurements were below this value. Consequently, the HRRR exhibited a positive soil moisture MBE over the drier areas of the western United States and a negative MBE over the eastern United States. Although caution is needed when applying conclusions regarding HRRR’s biases to locations with subgrid-scale land cover variations, general knowledge of HRRR’s biases will help guide improvements to land surface models used in high-resolution weather forecasting models.

Significance Statement

Weather forecasters rely upon output from many different models. However, the models’ ability to represent processes happening near the land surface over short time scales is critical for producing accurate weather forecasts. In this study, we evaluated the High-Resolution Rapid Refresh (HRRR) model using observations from the U.S. Climate Reference Network, which currently includes 114 reference climate observing stations in the contiguous United States. These stations provide highly accurate measurements of air temperature, precipitation, soil temperature, and soil moisture. Our findings helped illustrate conditions when the HRRR performs well, but also conditions in which the HRRR can be improved, which we expect will motivate ongoing improvements to the HRRR and other weather forecasting models.
Effect of 2 Teams and Operative Time on Complications After Oral Cavity Free Flap Reconstruction
Authors: Shaikh Noah , Noor Kinza , Jafary Haseeb , Chung Jeffson , Fancy Tanya , Stokes William
Published: April 2023

Objective:

Evaluate the effects of operative time and 2 team approach on complications after soft tissue free flap reconstruction for oral tongue cancer.

Methods:

Patients with oncologic glossectomy with myocutaneous or fasciocutaneous free flap reconstruction were included from the 2015 to 2018 American College of Surgery National Surgical Quality Improvement Program. The primary predictive variables assessed were operative time and 2 team approach; control variables included age, sex, body mass index (BMI), 5-question-modified frailty index (mFI-5), American Society of Anesthesiologists (ASA) class, and total work relative value units (wRVU). Outcomes assessed included 30-day mortality, 30-day reoperation, hospital length of stay beyond 30 days, readmission, medical and surgical complications, and non-home discharge. Multivariable logistic/linear regression models were used to predict surgical outcomes.

Results:

Microvascular soft tissue free flap reconstruction of the oral cavity after glossectomy was performed on 839 patients. Operative time was independently associated with readmission, prolonged length of stay, surgical complications, medical complications, and non-home discharge. A 2-team approach was independently associated with prolonged length of stay and medical complications. The mean operative time of the 1-team and 2-team approach was 8.73 and 9.13 hours. The 1-team approach did not significantly increase operative time ( P = .16).

Conclusions:

In the largest study to date of operative time on post-surgical outcomes after glossectomy and soft tissue free flap reconstruction, we found longer operative times increased rates of postoperative complications and non-home discharge. The 1-team approach is non-inferior to the 2-team approach with respect to operating time and complications.
Intensive and Extensive Margins of Export Diversification as Strategies for Sustainable Economic Growth: Evidence from the Nigerian Economy
Authors: Young Ademola Obafemi
Published: April 2023

Two opposite strands of literature analysing export diversification’s role in promoting sustainable growth have evolved in international economics and development, namely, the intensive and extensive margins of exports. This study empirically investigates which of the margin is more useful towards promoting sustainable growth using annual time series data of Nigeria for the period 1960–2021. Autoregressive distributed lag (ARDL) and innovative accounting procedure were employed. The ARDL results reveal that both margins significantly enhance growth in short and long run. However, importance of the extensive margin, in aggregate, dominates that of the intensive margin. Likewise, the results from innovative accounting procedures reveal that although both margins contribute positively to growth, the contribution to growth of extensive margin dominates over that of the intensive margin. These results, thus, lend credence to the extensive-margin exposition, which postulates that the export of extant commodities to new market destinations or export of new commodities to new and/or old market destinations plays a relatively more important role in export growth/diversification and, ultimately, sustainable growth. The study recommends that governments should develop and implement economic policies aimed at enhancing exports of value-added commodities—due to their relatively high income and price elasticities over primary commodities—to maximise the benefits in the extensive margin.

JEL Codes: F10, F14, O10, O12, O50, O55
The double-edged sword of negative supervisor gossip: When and why negative supervisor gossip promotes versus inhibits feedback seeking behavior among gossip targets
Authors: Zhu Qianlin , Martinescu Elena , Beersma Bianca , Wei Feng
Published: April 2023

How does being the target of negative supervisor gossip influence the functioning of targeted employees? We draw on feedback intervention theory to examine the beneficial and detrimental effects of negative supervisor gossip on targets’ feedback seeking behavior (FSB). Results from an online scenario study ( N = 731) and a multi-wave field study ( N = 249) showed that being the target of negative supervisor gossip led to high task reflexivity, which promoted FSB, but also led to high negative affect, which inhibited FSB. Furthermore, targets’ implicit theory of ability moderated the indirect relationships between negative supervisor gossip and FSB. Specifically, negative supervisor gossip stimulated task reflexivity and FSB especially when targets had a strong incremental theory. In contrast, negative supervisor gossip increased negative affect and stifled FSB especially when targets had a strong entity theory. Our findings indicate that negative supervisor gossip is a double-edged sword for targets’ engagement in FSB, thus providing a balanced view of its effects. We provide guidance for supervisors to better deliver and for employees to better receive different forms of feedback.
Multilevel power structure and local compliance with government transparency mandates: evidence from China's environmental transparency reform
Authors: Li Jin , Chen Shaowei
Published: April 2023

Despite the ample literature on government transparency, our knowledge about how the vertical power structure of governments shapes local compliance with government transparency mandates is still limited. This study sets out to address this gap. Specifically, we investigate how the central government's environmental information disclosure (EID) signal and provincial governments’ conflicting signal of economic growth affect, independently and interactively, city governments’ compliance with central EID mandates in the center-province-city hierarchical structure in China. We argue that the central EID signal positively affects city compliance, while the provincial signal of economic growth reduces it. Moreover, the provincial signal of economic growth negatively moderates the impact of the central EID signal. Empirically, with a panel dataset for city-level governments from 2008 to 2018, we found robust evidence strongly supporting our theoretical hypotheses.

Points for practitioners

This research reveals the influences of the complex dynamics among governments at different levels on local compliance with government transparency mandates. The findings suggest that the maneuvers of middle-level governments in a multilevel power structure and the interactions among multiple conflicting policy goals should be taken seriously by practitioners when designing policies to promote government transparency reforms.
Reprint: Problems, Process, and Promise: Reflections on a Collaborative Approach to the Solution of the Minority Teacher Shortage
Authors: Goodwin A. Lin
Published: April 2023

This paper describes the work of a nine-college consortium that aimed to address the minority teacher shortage. First, the consortium's beginnings, aims, and activities are presented. Then the collaborative process is analyzed in terms of nine factors that have been identified in the literature as contributors to effective collaboration: (a) commitment of institutional officials, (b) mutual needs and interests, (c) clarity about goals, roles, and control, (d) sufficient time, (e) energy, (f) effective communication, (g) resources, (h) leadership, and (i) ongoing evaluation. The analysis resulted in the identification of three additional factors that support successful collaboration: (a) levels of collaboration, (b) continual redefinition, and (c) avoidance of interinstitutional conflicts.