bluuebunny/crossref_metadata_2025 huggingface dataset:
Query Evaluation under Differential Privacy
Authors: Dong Wei , Yi Ke
Published: November 2023

Differential privacy has garnered significant attention in recent years due to its potential in offering robust privacy protection for individual data during analysis. With the increasing volume of sensitive information being collected by organizations and analyzed through SQL queries, the development of a general-purpose query engine that is capable of supporting a broad range of queries while maintaining differential privacy has become the holy grail in privacypreserving query release. Towards this goal, this article surveys recent advances in query evaluation under differential privacy.
Anticipating Challenges in Optical Nanobiosensors for Global Detection of Respiratory Viruses and Emerging Threats
Authors: Martínez Tolibia Shirlley E. , Galdámez-Martínez Andrés , Salinas Rafael A. , Dutt Ateet
Published: November 2023

The unprecedented SARS-CoV-2 pandemic has opened huge opportunities for nanomaterial-based biosensors focused on timely detection of emerging respiratory viruses, where challenges must address actions for fast response and massive application. Accordingly, we provide a comprehensive perspective on critical aspects, including nanomaterials, biofunctionalization strategies, and bioreceptors engineering to increase accuracy, emphasizing optical nanobiosensors. The first biosensing prototype performance reveals the need to consider crucial factors for improvement, such as handling detection in complex matrices, standardization for commercial purposes, portability, integration with artificial intelligence, sustainability, and economic feasibility. By achieving these goals, biosensors would foster a prepared global healthcare landscape.
Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease
Authors: Mathew Anna V. , Kayampilly Pradeep , Byun Jaeman , Nair Viji , Afshinnia Farsad , Chai Biaoxin , Brosius Frank C. , Kretzler Matthias , Pennathur Subramaniam
Published: November 2023

Tubular dysfunction explains the association between the nucleosides pseudouridine and N2 N2-dimethyl guanosine and diabetic kidney disease.
β2-Adrenergic receptor agonists as a treatment for diabetic kidney disease
Authors: Arif Ehtesham , Medunjanin Danira , Solanki Ashish , Zuo Xiaofeng , Su Yanhui , Dang Yujing , Winkler Brennan , Lerner Kasey , Kamal Ahmed I. , Palygin Oleg , Cornier Marc-Andre , Wolf Bethany J. , Hunt Kelly J. , Lipschutz Joshua H.
Published: November 2023

Diabetic nephropathy is the most common cause of ESKD. Formoterol, a long-acting β2-adrenergic receptor (β2-AR) agonist, reversed diabetic nephropathy in murine models of type 1 and 2 diabetes. In humans, there was an association with protection from progression of CKD in patients with COPD, by means of β2-AR agonist intake, compared with those without COPD. These data indicate that β2-AR agonists, especially formoterol, could be a new treatment for diabetic nephropathy and other forms of CKD.
Impaired cardiorespiratory fitness and endothelial function after SARS-CoV-2 infection in a sample of mainly immunocompromised youth
Authors: Astley Camilla , Prado Danilo Marcelo Leite do , Sieczkowska Sofia Mendes , Esteves Gabriel P. , Suguita Priscila , Fink Thais , Lindoso Livia , Matsuo Olivia , Martins Fernanda , Bain Vera , Badue Pereira Maria Fernanda , Marques Heloisa Helena , Malluf Adriana , Leal Gabriela Nunes , Silva Clovis Artur , Roschel Hamilton , Gualano Bruno
Published: November 2023

COVID-19 appeared to impair recovery of exercise capacity and endothelial function in a sample mainly comprising immunocompromised patients, but the mechanisms are unknown. These findings support the need for preventive measures against COVID-19 in this vulnerable population and suggest the necessity of proper monitoring and treatment for these patients.
Stem Cell-Based Therapy and Cell-Free Therapy as an Alternative Approach for Cardiac Regeneration
Authors: Deszcz Iwona
Published: November 2023

The World Health Organization reports that cardiovascular diseases (CVDs) represent 32% of all global deaths. The ineffectiveness of conventional therapies in CVDs encourages the development of novel, minimally invasive therapeutic strategies for the healing and regeneration of damaged tissue. The self-renewal capacity, multilineage differentiation, lack of immunogenicity, and immunosuppressive properties of mesenchymal stem cells (MSCs) make them a promising option for CVDs. However, growing evidence suggests that myocardial regeneration occurs through paracrine factors and extracellular vesicle (EV) secretion, rather than through differentiation into cardiomyocytes. Research shows that stem cells secrete or surface-shed into their culture media various cytokines, chemokines, growth factors, anti-inflammatory factors, and EVs, which constitute an MSC-conditioned medium (MSC-CM) or the secretome. The use of MSC-CM enhances cardiac repair through resident heart cell differentiation, proliferation, scar mass reduction, a decrease in infarct wall thickness, and cardiac function improvement comparable to MSCs without their side effects. This review highlights the limitations and benefits of therapies based on stem cells and their secretome as an innovative treatment of CVDs.
Investigation for Factors Affecting Body Perception Disturbance in Patients with Low Back Pain by Mechanism-Based Classification of Pain: A Cross-Sectional Study
Authors: Kurashima Yoshito , Nakamura Takumi , Mukaiyama Taishi , Hasegawa Kenji , Kuruma Hironobu
Published: November 2023

Background. Central sensitization is a pathophysiological cause of chronic low back pain and is linked with psychosocial factors. The association between central sensitization (CS) and body perception disturbance is currently unclear, and no prior studies have investigated this relationship in patients with acute or subacute low back pain. The objective of this study was to investigate potential factors that influence body perception disturbance using a mechanistic classification of low back pain. Methods. This cross-sectional study was conducted at the time of initial physical therapy in patients with low back pain. During the study period, 169 patients were recruited. Pain intensity, disease duration, disability, CS, and body perception disturbance were evaluated. Patients were divided into three groups according to the pathology of low back pain, and multivariate analysis was used to examine factors affecting body perception disturbance. The dependent variable was Fremantle Back Awareness Questionnaire (FreBAQ); the independent variables were age, gender, BMI, VAS, disease duration, RDQ, and CS Inventory-9 (CSI-9). Results. A total of 117 patients were included in our analysis. According to the mechanistic classification of pain, 66 (56.4%), 36 (30.8%), and 15 (12.8%) patients were categorized as having nociceptive pain (NP), peripheral neuropathic pain (PNP), and CS pain (CSP), respectively. Patients with PNP or CSP were significantly older than those with NP

p
 
<
 
0.01

. FreBAQ and RDQ scores were significantly higher in patients with CSP than those with NP

p
 
<
 
0.05

. The results of multiple regression analyses indicated that CSI-9 scores were significantly associated with FreBAQ

p
 
<
 
0.01

. Conclusion. Patients with CS syndrome and low back pain tend to have higher CSI-9 scores and be older. Body perception disturbance is influenced by CS or CS syndrome, regardless of the stage of low back pain, suggesting that patients with chronic low back pain tend to have low body image.
A Real-World Safety Analysis of Upadacitinib Based on FDA Adverse Event Reporting System (FAERS)
Authors: Zhao Yazheng , Cheng Qian , Zou Shupeng , Shi Xuan , Ouyang Mengling , Sun Minghui
Published: November 2023

Objectives. To investigate adverse events (AEs) associated with upadacitinib in the real world using data mining from the FDA Adverse Event Reporting System (FAERS). Methods. Disproportionality analysis, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the multiitem gamma Poisson shrinker (MGPS) algorithms, was used to quantify the signals of upadacitinib-associated AEs. Results. The study found 23683 reports of AEs associated with upadacitinib. A total of 149 substantial disproportionality preferred terms (PTs) that complied with all algorithms were identified. The infections discovered matched those mentioned in the specification and clinical trials, including pneumonia, upper respiratory tract infection, herpes zoster, and acne. Malignant and thrombotic AEs were also noted. Diverticulitis, myocardial infarction, transient ischaemic attack, and dysstasia were among the new AEs found. Upadacitinib-related AEs had a median onset time of 237 days and an interquartile range (IQR) of 78–509 days. Conclusions. The findings of our study were in line with clinical observations, and we also identified potential novel and unexpected AEs signals for upadacitinib, indicating the necessity for prospective clinical trials to corroborate these findings and demonstrate their link. Our results offered significant support for additional upadacitinib safety research.
A Fully Automated Deep-Learning Model for Predicting the Molecular Subtypes of Posterior Fossa Ependymomas Using T2-Weighted Images
Authors: Cheng Dan , Zhuo Zhizheng , Du Jiang , Weng Jinyuan , Zhang Chengzhou , Duan Yunyun , Sun Ting , Wu Minghao , Guo Min , Hua Tiantian , Jin Ying , Peng Boyang , Li Zhaohui , Zhu Mingwang , Imami Maliha , Bettegowda Chetan , Sair Haris , Bai Harrison X. , Barkhof Frederik , Liu Xing , Liu Yaou
Published: November 2023

Purpose:

We aimed to develop and validate a deep learning (DL) model to automatically segment posterior fossa ependymoma (PF-EPN) and predict its molecular subtypes [Group A (PFA) and Group B (PFB)] from preoperative MR images.

Experimental Design:

We retrospectively identified 227 PF-EPNs (development and internal test sets) with available preoperative T2-weighted (T2w) MR images and molecular status to develop and test a 3D nnU-Net (referred to as T2-nnU-Net) for tumor segmentation and molecular subtype prediction. The network was externally tested using an external independent set [n = 40; subset-1 (n = 31) and subset-2 (n =9)] and prospectively enrolled cases [prospective validation set (n = 27)]. The Dice similarity coefficient was used to evaluate the segmentation performance. Receiver operating characteristic analysis for molecular subtype prediction was performed.

Results:

For tumor segmentation, the T2-nnU-Net achieved a Dice score of 0.94 ± 0.02 in the internal test set. For molecular subtype prediction, the T2-nnU-Net achieved an AUC of 0.93 and accuracy of 0.89 in the internal test set, an AUC of 0.99 and accuracy of 0.93 in the external test set. In the prospective validation set, the model achieved an AUC of 0.93 and an accuracy of 0.89. The predictive performance of T2-nnU-Net was superior or comparable to that of demographic and multiple radiologic features (AUCs ranging from 0.87 to 0.95).

Conclusions:

A fully automated DL model was developed and validated to accurately segment PF-EPNs and predict molecular subtypes using only T2w MR images, which could help in clinical decision-making.
Experiences of Family Communication and Cascade Genetic Testing for Hereditary Cancer in Medically Underserved Populations—A Qualitative Study
Authors: Bednar Erica M. , Rauh-Hain J. Alejandro , Garcia Jose J. , de Aguinaga Norma , Powell Mary Anne , Peral Sylvia L. , Nitecki Roni , Jorgensen Kirsten , Rudy Natasha L. , Lu Karen H. , Leath Charles A. , Scarinci Isabel C.
Published: November 2023

We sought to explore the intrafamilial communication and cascade genetic testing (CGT) experiences of patients with hereditary cancer from diverse, medically underserved populations and their relatives. Participants included patients receiving oncology care at an urban, safety net hospital in Texas or comprehensive cancer center in Alabama and their first-degree relatives. In-depth semi-structured qualitative interviews were completed wherein patients shared their experiences with genetic counseling (GC), genetic testing (GT), and communicating their results to relatives. Relatives shared their experiences receiving information from the patient and considering CGT. Interviews were transcribed, coded, and themes were identified. Of 25 participating patients, most recalled key aspects of GC and their GT results. Most (80%) patients shared their results with relatives, but only some relatives underwent CGT; patients reported low perceived susceptibility to hereditary cancer as a common barrier to CGT for their relatives. Of 16 participating relatives, most reported feeling distress upon learning the patient's GT results. Relatives were fearful of learning their own CGT results but identified prevention and early detection as CGT benefits. Interviews identified opportunities during family communication to improve relatives’ perceived susceptibility to hereditary cancer. Tailored resources may support patients and relatives experiencing distress and fear during GT.

Prevention Relevance:

This study of intrafamilial communication and cascade genetic testing experiences of patients with hereditary cancer and their relatives from diverse, medically underserved populations identified relatives’ perceived susceptibility to hereditary cancer risks, distress, and fear as frequent reactions and barriers to testing. These results may inform future hereditary cancer prevention efforts.
Criteria for Diagnosis and Molecular Monitoring of NPM1-Mutated AML
Authors: Falini Brunangelo , Dillon Richard
Published: November 2023

NPM1-mutated acute myeloid leukemia (AML) represents the largest molecular subgroup of adult AML. NPM1-mutated AML is recognizable by molecular techniques and immunohistochemistry, which, when combined, can solve difficult diagnostic problems (including identification of myeloid sarcoma and NPM1 mutations outside exon 12). According to updated 2022 European LeukemiaNet (ELN) guidelines, determining the mutational status of NPM1 (and FLT3) is a mandatory step for the genetic-based risk stratification of AML. Monitoring of measurable residual disease (MRD) by qRT-PCR, combined with ELN risk stratification, can guide therapeutic decisions at the post-remission stage. Here, we review the criteria for appropriate diagnosis and molecular monitoring of NPM1-mutated AML.

Significance:

NPM1-mutated AML represents a distinct entity in the 2022 International Consensus Classification and 5th edition of World Health Organization classifications of myeloid neoplasms. The correct diagnosis of NPM1-mutated AML and its distinction from other AML entities is extremely important because it has clinical implications for the management of AML patients, such as genetic-based risk stratification according to 2022 ELN. Monitoring of MRD by qRT-PCR, combined with ELN risk stratification, can guide therapeutic decisions at the post-remission stage, e.g., whether or not to perform allogeneic hematopoietic stem cell transplantation.
Timing of Cognitive Test Score Decline Prior to Incident Dementia Diagnosis in Blacks and Whites: The Atherosclerosis Risk in Communities Neurocognitive Study
Authors: Wang Yunzhi , Sharrett A. Richey , Schneider Andrea L.C. , Knopman David , Hu Jiaqi , Gottesman Rebecca , Sullivan Kevin J. , Coresh Josef
Published: November 2023

Introduction: Commonly occurring dementias include those of Alzheimer’s, vascular, and mixtures of these and other pathologies. They are believed to evolve over many years, but that time interval has been difficult to establish. Our objective was to determine how many years in advance of a dementia diagnosis cognitive scores begin to change. Methods: 14,086 dementia-free ARIC participants underwent a cognitive exam at baseline visit 2 (1990–1992, mean age 57 ± 5.72), and 11,244 at visit 4 (1996–1998), 5,640 at visit 5 (2011–2013), and 3,574 at visit 6 (2016–2017) with surveillance for dementias of all-causes combined. Within 5-year intervals after each visit, we compared performance on the Delayed Word Recall Test (DWRT), the Digit Symbol Substitution Test (DSST), the Word Fluency Test (WFT), and the combined mean of three cognitive tests at baseline in participants who were diagnosed with dementia within each interval versus those who survived the interval without a dementia diagnosis. Z-scores were adjusted for demographics and education in separate regression models for each visit. We plotted adjusted z-score means by time interval following each visit. Results: During follow-up 3,334, 2,821, 1,218, and 329 dementia cases were ascertained after visits 2, 4, 5, and 6, respectively. Adjusted DWRT z-scores were significantly lower 20–25 years before dementia than those who did not experience dementia within 25 years. DSST z-scores were significantly lower at 25–30 years and 3-test combination z-scores were significantly lower as early as 30–31 years before onset. The difference between dementia and non-dementia group in the visit 2 3-test combination z-score was −0.20 at 30–31 years prior to dementia diagnosis. As expected, differences between the dementia and non-dementia groups increased closer to the time of dementia occurrence, up to their widest point at 0–5 years prior to dementia diagnosis. The difference between dementia and non-dementia groups in the visit 2 3-test combination z-score at 0–5 years was −0.90. WFT z-score differences were smaller than for the DSST or DWRT and began later. Patterns were similar in Black and White participants. Conclusion: DWRT, DSST, and combined 3-test z-scores were significantly lower more than 20 years prior to diagnosis in the dementia group versus the non-dementia group. Findings contribute to our knowledge of the long prodromal period in Blacks and Whites.
Rare Case of Advanced Gastric Cancer Complicated with Fibrinogen Storage Disease Treated with Chemotherapy plus Immune Checkpoint Inhibitor: A Case Report
Authors: Kawaguchi Daiki , Kawakami Takeshi , Kakuda Yuko , Yamazaki Kentaro
Published: November 2023

The administration of chemotherapy to cancer patients with organ dysfunction raises concerns regarding its safety. The safety profile of patients with organ dysfunction due to rare diseases treated with chemotherapy plus immune checkpoint inhibitor is limited. Fibrinogen storage disease (FSD) is a rare disease that causes liver dysfunction through endoplasmic reticulum stress response due to abnormal accumulation of fibrinogen in the endoplasmic reticulum of hepatocytes. Although chemotherapy plus nivolumab is recommended as a standard first-line treatment for patients with advanced gastric cancer (AGC), its safety profile for patients with FSD is rarely available. In this study, an 80-year-old male with gastric cancer with positive lavage cytology was scheduled to receive palliative chemotherapy. This case had liver dysfunction of unknown cause, and a liver biopsy was performed. Histopathological findings revealed a diagnosis of type II/III fibrinogen inclusion based on morphology and immunohistochemistry. Liver function was recovered by administering ursodeoxycholic acid. Therefore, the combination chemotherapy of S-1, oxaliplatin, with nivolumab as palliative chemotherapy was initiated. The case responded well to chemotherapy and achieved conversion surgery without worsening of liver function. We report a case of AGC with fibrinogen inclusion complication where chemotherapy was safely administered with a good outcome. The combination therapy of cytotoxic drugs and immune checkpoint inhibitors may be safely and effectively administered to such patients.
Validation of the Norwegian Version of the Speech, Spatial and Qualities of Hearing Scale (SSQ)
Authors: Myhrum Marte , Heldahl Mariann Gjervik , Rødvik Arne Kirkhorn , Tvete Ole Edvard , Jablonski Greg Eigner
Published: November 2023

Introduction: The main objective of the study was to validate the Norwegian translation of the Speech, Spatial and Qualities of Hearing Scale (SSQ) and investigate the SSQ disability profiles in a cochlear implant (CI) user population. Methods: The study involved 152 adult CI users. The mean age at implantation was 55 (standard deviation [SD] = 16), and the mean CI experience was 5 years (SD = 4.8). The cohort was split into three groups depending on the hearing modality: bilateral CIs (BCIs), a unilateral CI (UCI), and bimodal (CI plus contralateral hearing aid; HCI). The SSQ disability profiles of each group were compared with those observed in similar studies using the English version and other translations of the SSQ. Standard values, internal consistency, sensitivity, and floor and ceiling effects were investigated, and the missing-response rates to specific questions were calculated. Relationships to speech perception were measured using monosyllabic word scores and the Norwegian Hearing in Noise Test scores. Results: In the BCI group, the average scores were around 5.0 for the speech and spatial sections and 7.0 for the qualities section (SD ∼2). The average scores of the UCI and HCI groups were about one point lower than those of the BCI group. The SSQ disability profiles were comparable to the profiles in similar studies. The slopes of the linear regression lines measuring the relationships between the SSQ speech and monosyllabic word scores were 0.8 per 10% increase in the monosyllabic word score for the BCI group (explaining 35% of the variation) and 0.4 for the UCI and HCI groups (explaining 22–23% of the variation). Conclusion: The Norwegian version of the SSQ measures hearing disability similar to the original English version, and the internal consistency is good. Differences in the recipients’ pre-implantation variables could explain some variations we observed in the SSQ responses, and such predictors should be investigated. Data aggregation will be possible using the SSQ as a routine clinical assessment in global CI populations. Moreover, pre-implantation variables should be systematically registered so that they can be used in mixed-effects models.
Comparison of Different Prediction Models for Unplanned Interruption of Continuous Renal Replacement Treatment: A Systematic Review of Qualitative Analyses
Authors: Zhang Yanting , Li Zhaoyang , Li Jin , Ding Xinbo , Ma Jing
Published: November 2023

Introduction: This study will systematically search and evaluate the prediction models for unplanned interruption of continuous renal replacement treatment (CRRT) and to provide a reference for building a higher quality prediction model for unplanned interruption of CRRT. Methods: PubMed, Embase, Cochrane Library, CINAHL, China National Knowledge Infrastructure (CNKI), SinoMed, and Wanfang Database were systematically searched for studies on prediction models for unexpected interruption of CRRT. The languages were limited to Chinese and English. The search time limit was from the establishment of the database to June 30, 2023. Two researchers screened the literature and extracted the data independently, and the risk of bias and applicability of the included literature were analyzed using the risk of bias assessment tool for predictive model studies. Results: A total of nine studies were included, and the area under the receiver operating characteristic curve ranged from 0.679 to 0.997. The applicability of the prediction model in seven studies was good and in two studies was poor. Conclusion: More attention should be paid to the effectiveness of different risk assessment methods in future construction, so as to obtain better risk prediction models with high accuracy and provide certain reference and basis for formulating relevant prevention strategies.
Efficacy of the Cytokine Adsorption Therapy in Patients with Severe COVID-19-Associated Pneumonia: Lesson Learned from a Prospective Observational Study
Authors: Kusirisin Prit , Noppakun Kajohnsak , Trongtrakul Konlawij , Vongsanim Surachet , Suteeka Yuttitham , Ophascharoensuk Vuddhidej , Pongsuwan Karn , Narongkiatikhun Phoom , Theerakittikul Theerakorn , Apaijai Nattayaporn , Chattipakorn Siriporn C. , Chattipakorn Nipon , Srisawat Nattachai
Published: November 2023

Introduction: Severe COVID-19 pneumonia can activate a cytokine storm. Hemoperfusion can reduce pro-inflammatory cytokines in sepsis but is still debated in the COVID-19 setting. Thus, we sought to investigate the benefits of HA-330 cytokine adsorption through clinical and laboratory outcomes. Methods: We conducted a single-center prospective observational study in adults with severe COVID-19 pneumonia admitted to the intensive care unit at Chiang Mai University Hospital (Chiang Mai, Thailand). Those with cytokine storms indicated by organ injury, including acute respiratory distress syndrome (ARDS), and high inflammatory markers were included. Patients treated with the HA-330 device were classified as a hemoperfusion group, while those without cytokine adsorption were classified as a control group. We compared the outcomes on day 7 after treatment and evaluated the factors associated with 60-day mortality. Results: A total of 112 patients were enrolled. Thirty-eight patients received hemoperfusion, while 74 patients did not. Baseline cytokine storm parameters were comparable. In univariate analysis, there was an improvement in clinical and laboratory effects from hemoperfusion therapy. In multivariate analysis, APACHE II score, SOFA score, PaO2/FiO2, the number of hemoperfusion sessions, the amount of blood purified, high-sensitivity C-reactive protein, and IL-6 were associated with mortality. Using at least 3 sessions of hemoperfusion could mitigate, the 60-day mortality (adjusted odds ratio 0.25, 95% confidence interval: 0.03–0.33, p = 0.001). By categorizing the amount of blood treated into 3 groups of <1 L/kg, 1–2 L/kg, and ≥2 L/kg, there was a linear dose-response association with survival, which was better in the higher volume purified (mortality 60% vs. 33.3% vs. 0%, respectively, p = 0.015). Conclusions: The early initiation of HA-330 hemoperfusion could improve the severity score and laboratory outcomes of COVID-19 ARDS. The optimal dose of at least three sessions or the amount of blood purified greater than 1 L/kg was associated with a reduction in 60-day mortality.
Os três mosqueteiros daqui
Authors: Cervo Amado Luiz
Published: November 2023

.
Nova ordem mundial: oportunidades e desafios para a Lusofonia
Authors: Xavier Aurobindo
Published: November 2023

Neste trabalho é abordada primeiro a nova ordem mundial emergente sob perspetiva histórica, levando em consideração as duas Grandes Guerras, o consequente multilateralismo, o surgimento do mundo bipolar pós segunda Grande guerra e a Ascensão e declínio do Mundo Unipolar sob a Hegemonia dos EUA. Seguidamente é descrita a força política e económica da China e da Rússia, os novos global players que dominarão a estruturação da nova ordem mundial juntamente com os EUA. Neste contexto é focada a possível influência da China e da Rússia nos países lusófonos, especialmente os situados na África e no Brasil. No final discute-se até que ponto a lusofonia pode e deve tornar-se um poder global, e a CPLP (Comunidade dos Países de Língua Portuguesa) como expressão desse poder, deve enquadrar-se na nova ordem mundial. Os pressupostos desse enquadramento são discutidos e exigem, para além de uma unidade muito forte dos países lusófonos, uma estratégia de política externa para articular e traduzir a força lusófona numa abordagem integrada e fazer fluir sua força econômica e institucional em uma nova política mundial.
State-of-the-Art Imaging of Infiltrative Cardiomyopathies: A Scientific Statement From the American Heart Association
Authors: Kottam Anupama , Hanneman Kate , Schenone Aldo , Daubert Melissa A. , Sidhu Gursukhman Deep , Gropler Robert J. , Garcia Mario J. ,   on behalf of the American Heart Association Council on Cardiovascular Radiology and Intervention
Published: November 2023

Infiltrative cardiomyopathies comprise a broad spectrum of inherited or acquired conditions caused by deposition of abnormal substances within the myocardium. Increased wall thickness, inflammation, microvascular dysfunction, and fibrosis are the common pathological processes that lead to abnormal myocardial filling, chamber dilation, and disruption of conduction system. Advanced disease presents as heart failure and cardiac arrhythmias conferring poor prognosis. Infiltrative cardiomyopathies are often diagnosed late or misclassified as other more common conditions, such as hypertrophic cardiomyopathy, hypertensive heart disease, ischemic or other forms of nonischemic cardiomyopathies. Accurate diagnosis is also critical because clinical features, testing methodologies, and approach to treatment vary significantly even within the different types of infiltrative cardiomyopathies on the basis of the type of substance deposited. Substantial advances in noninvasive cardiac imaging have enabled accurate and early diagnosis. thereby eliminating the need for endomyocardial biopsy in most cases. This scientific statement discusses the role of contemporary multimodality imaging of infiltrative cardiomyopathies, including echocardiography, nuclear and cardiac magnetic resonance imaging in the diagnosis, prognostication, and assessment of response to treatment.
Antiplatelet Agent Use After Stroke due to Intracerebral Hemorrhage
Authors: Al-Shahi Salman Rustam , Greenberg Steven M.
Published: November 2023

This focused update about antiplatelet agents to reduce the high risk of major adverse cardiovascular events after stroke due to spontaneous (nontraumatic) intracerebral hemorrhage (ICH) complements earlier updates about blood pressure-lowering, lipid-lowering, and oral anticoagulation or left atrial appendage occlusion for atrial fibrillation after ICH. When used for secondary prevention in people without ICH, antiplatelet agents reduce the risk of major adverse cardiovascular event (rate ratio, 0.81 [95% CI, 0.75–0.87]) and might increase the risk of ICH (rate ratio, 1.67 [95% CI, 0.97–2.90]). Before 2019, guidance for clinical decisions about antiplatelet agent use after ICH has focused on estimating patients’ predicted absolute risks and severities of ischemic and hemorrhagic major adverse cardiovascular event and applying the known effects of these drugs in people without ICH to estimate whether individual ICH survivors in clinical practice might be helped or harmed by antiplatelet agents. In 2019, the main results of the RESTART (Restart or Stop Antithrombotics Randomized Trial) randomized controlled trial including 537 survivors of ICH associated with antithrombotic drug use showed, counterintuitively, that antiplatelet agents might not increase the risk of recurrent ICH compared to antiplatelet agent avoidance over 2 years of follow-up (12/268 [4%] versus 23/268 [9%]; adjusted hazard ratio, 0.51 [95% CI, 0.25–1.03];
P
=0.060). Guidelines in the United States, Canada, China, and the United Kingdom and Ireland have classified the level of evidence as B and indicated that antiplatelet agents may be considered/reasonable after ICH associated with antithrombotic agent use. Three subsequent clinical trials have recruited another 174 participants with ICH, but they will not be sufficient to determine the effects of antiplatelet therapy on all major adverse cardiovascular events reliably when pooled with RESTART. Therefore, ASPIRING (Antiplatelet Secondary Prevention International Randomized Study After Intracerebral Hemorrhage) aims to recruit 4148 ICH survivors to determine the effects of antiplatelet agents after ICH definitively overall and in subgroups.
The Media and the Islands Crisis
Authors: Abdelrahim Amr
Published: November 2023

Attracting large audiences during the late Mubarak era and the revolutionary period that followed, Egyptian political talk show hosts played an important role in supporting the authoritarian rollback initiated during the summer of 2013 before seemingly losing much of their hard-won influence. To understand their marginalization better, this article claims that the habits and practices these secular preachers acquired, through a relatively autonomous configuration of their field, did not match the post-2013 regime’s media vision. This observation is supported by discourse analysis of the hosts covering the 2016 Islands crisis, highlighting how their discursive strategies, namely the pluralistic ‘in-betweenness’ of most pundits, were rooted in their career trajectories and how they failed to contain the dislocation of the hegemonic discourse, thereby pushing securocrats to strip the media field of its remaining autonomy.
Quantification of Long-Range Dependence in Hydroclimatic Time Series: A Method-Comparison Study
Authors: Niu Jingyi , Xie Ping , Sang Yan-Fang , Zhang Liping , Wu Linqian , Zhu Yanxin , Sivakumar Bellie , Huo Jingqun , Chen Deliang
Published: November 2023

Accurate evaluation of the long-range dependence in hydroclimatic time series is important for understanding its inherent characteristics. However, the reliability of its evaluation may be questioned, since different methods may yield various outcomes. In this study, we evaluate the performances of seven widely used methods for estimating long-range dependence: absolute moment estimation, difference variance estimation, residuals variance estimation, rescaled range estimation, periodogram estimation, wavelet estimation (WLE), and discrete second derivative estimation (DSDE). We examine the influences of six major factors: data length, mean value, three nonstationary components (trend, jump, and periodicity), and one stationary component (short-range dependence). Results from the Monte Carlo experiments show that WLE and DSDE have greater credibility than the other five methods. They also reveal that data length, as well as stationary and nonstationary components, have notable influences on the evaluation of long-range dependence. Following it, we use the WLE and DSDE methods to evaluate the long-range dependence of precipitation during 1961–2015 on the Tibetan Plateau. The results indicate that the precipitation variability mirrors the long-range dependence of the Indian summer monsoon but with obvious spatial difference. This result is consistent with the observations made by previous studies, further confirming the superiority of the WLE and DSDE methods. The outcomes from this study have important implications for modeling and prediction of hydroclimatic time series.
Improving Simulations of Warm Rain in a Bulk Microphysics Scheme
Authors: Conrick Robert , Mass Clifford F. , McMurdie Lynn
Published: November 2023

Current bulk microphysical parameterization schemes underpredict precipitation intensities and drop size distributions (DSDs) during warm rain periods, particularly upwind of coastal terrain. To help address this deficiency, this study introduces a set of modifications, called RCON, to the liquid-phase (warm rain) parameterization currently used in the Thompson–Eidhammer microphysical parameterization scheme. RCON introduces several model modifications, motivated by evaluating simulations from a bin scheme, which together result in more accurate precipitation simulations during periods of warm rain. Among the most significant changes are 1) the use of a wider cloud water DSD of lognormal shape instead of the gamma DSD used by the Thompson–Eidhammer parameterization and 2) enhancement of the cloud-to-rain autoconversion parameterization. Evaluation of RCON is performed for two warm rain events and an extended period during the Olympic Mountains Experiment (OLYMPEX) field campaign of winter 2015/16. We show that RCON modifications produce more realistic precipitation distributions and rain DSDs than the default Thompson–Eidhammer configuration. For the multimonth OLYMPEX period, we show that rain rates, rainwater mixing ratios, and raindrop number concentrations were increased relative to the Thompson–Eidhammer microphysical parameterization, while concurrently decreasing raindrop diameters in liquid-phase clouds. These changes are consistent with an increase in simulated warm rain. Finally, real-time evaluation of the scheme from August 2021 to August 2022 demonstrated improved precipitation prediction over coastal areas of the Pacific Northwest.

Significance Statement

Although the accurate simulation of warm rain is critical to forecasting the hydrology of coastal areas and windward slopes, many warm rain parameterizations underpredict precipitation in these locations. This study introduces and evaluates modifications to the Thompson–Eidhammer microphysics parameterization scheme that significantly improve the accuracy of rainfall prediction in those regions.
Intravenous Iron for Heart Failure: Updated Systematic Review and Meta-Analysis
Authors: Techasatian Witina , Nishimura Yoshito , Tanariyakul Manasawee , Morihara Clarke , Arayangkool Chinnawat , Settle Alexander , Aiumtrakul Noppawit , Kewcharoen Jakrin
Published: November 2023

While the administration of intravenous (IV) iron to those with heart failure has been implicated to be associated with a possible reduction in hospitalizations and improvement in symptoms, a recent large multicenter trial only showed modest benefits in reducing hospitalization, necessitating the updated systematic review. We conducted a systematic review and meta-analysis, searching the MEDLINE and EMBASE database until January 9, 2023. Outcomes included total heart failure hospitalizations, first heart failure hospitalization, six-minute walk test (6MWT) distance, and incidence of infection. There were 13 studies with 3410 participants (1,790 with IV iron). Pooled analysis that reported the incidence of cardiovascular death showed that patients with IV iron did not have significantly lower odds of cardiovascular death or first heart failure hospitalization. In contrast, those who received IV iron had significantly lower total heart failure hospitalization (pooled odds ratio (OR) 0.63, 95% confidence interval (CI) 0.44-0.90, I2 59.0%, P = .017) and a composite of cardiovascular death and first heart failure hospitalization (pooled OR 0.55, 95% CI 0.47-0.64, I2 0%, P = .656). While the efficacy is modest, IV iron therapy could be associated with reduced hospitalization for heart failure without significant adverse events.
A Meta-Analysis of the Effects of Taekwondo on Physical Self-Concept
Authors: Ju Hanyu , Han Zhengfa , Gao Yujie
Published: November 2023

In this meta-analysis we explored whether Taekwondo practice has improved its participants’ physical self-concepts. We also tested the mediating influence of factors in past research such as country, participant age, and measurement properties in their associations with these taekwondo effects. We reviewed extensive data collected from Chinese, English and Korean participants in articles listed in Cnki, Wanfang, PubMed, Web of Science, KISS, RISS, and DBPIA databases. First, we evaluated the methodological quality of these published articles with Review Manager 5.4 software according to the Cochrane System Evaluation Manual. Then, we used Comprehensive Meta-Analysis 3.7 software for statistical analysis. We based these analyses on nine research studies containing a total of 1154 participants. We found a significant association between taekwondo activity and an improved body self-concept (ES = .688, p < .001). Subgroup analyses showed a stronger association between these variables in Korea (ES = .90, p < .001) than in China (ES = .34, p < .001), a stronger association for children (ES = 1.04, p < .001) compared to adults (ES = .46, p < .001), and a stronger association with the modified version of the Physical Self-Description Questionnaire (PSDQ) (ES = .99, p < .001) than with the original PSDQ (ES = .57, p < .001). We concluded that practicing Taekwondo led to improved physical self-concept, especially in a younger population. In addition, the experimental design and measurement methods may influence the apparent link between these variables.
Evolving in the Shadows: A Media Ecology Study of Dark Web Social Networks
Authors: Madouh Mohammed , Kwon K. Hazel
Published: November 2023

This study conceptualizes dark web social networks (DWSNs) through the lens of media ecology theory. We synthesize existing literature to problematize a lack of understanding of DWSNs as a communicatively organizing system. The discussion then focuses on how DWSNs complement, compete, and hybridize with surface web social networks (SWSNs). This Interaction shapes DWSNs as communities of practice that both serve and evolve with the communicative and informational needs of their users. We introduce and elaborate two media-ecological concepts of DWSNs: (1) a medium that has become a message of antithesis to Web 2.0 and (2) an organism that has coevolved with SWSNs. An empirical indicator to explicate these two concepts is The Hub, one of the long-lasting DWSNs. The Hub serves as an example to juxtapose DWSNs with SWSNs, with a focus on their intermedia relationship, and characterize the symbiosis between DWSNs as hosts and their users as living organisms.
Advanced renal pelvis carcinoma patient with an ERBB2 insertion mutation: a case report
Authors: Shang Peipei , Lou Cheng , Yin Lei , Tao Chenjie , Dong Yulong , Yang Guang , Yuan Zhengang
Published: November 2023

The prognosis of renal pelvis cancer is poor and therapeutic options are limited, especially for patients with advanced disease. In this report, we present a case of advanced renal pelvis carcinoma in a male patient in his 60s, characterized by an activating mutation in ERBB2. Clinical evaluation resulted in a pathological diagnosis of renal pelvis carcinoma with liver metastasis. Immunohistochemistry staining results suggested that CK, P63, and PAX8 were positively expressed, while Sy, CK7, CK20, S100, PAX8, and HEP1 were negatively expressed. Furthermore, next-generation sequencing results showed an activating mutation in the ERBB2 gene. The patient initially received a trastuzumab-based combination therapy, which led to a significant reduction in ERBB2 mutation frequency and a stable condition after three treatment cycles. However, following continuous treatment for 4 months, the patient developed drug resistance that resulted in disease relapse. Subsequently, the patient received apatinib treatment, but the therapeutic response was not satisfactory. The patient’s condition underwent rapid deterioration and he ultimately succumbed to the disease. This case underscores the potential benefit of trastuzumab for treating ERBB2-mutated advanced renal pelvis cancer, but further highlights that overcoming drug resistance remains a crucial challenge for long-term efficacy.
Safety Risk of Nonmotorized Vehicles from the Perspective of Motorized Vehicle Drivers
Authors: Ahmed Niaz , Chowdhury Shoumic Shahid , Tanim Md Fardeen , Ahammed Dewan Tanvir , Raihan Md Asif , Hossain Moinul
Published: November 2023

Collisions with motorized vehicles (MVs) are one of the leading causes of nonmotorized vehicle (NMV) crashes in a heterogeneous traffic stream. As well as NMVs’ inherent vulnerability, MV drivers’ risk perceptions of NMVs may also influence MV–NMV crashes. However, until now, this subjective perception has been little explored in the literature. This study examines the potential impact of numerous factors associated with motorized road users’ perception of risk and the operational aspects of NMVs on MV–NMV crashes. An ordered probit model was developed using self-reported data from 1,560 Dhaka city motorists (motorcyclists, and car and bus drivers). Findings revealed that motorists have a higher probability of becoming aggressive, deem NMV drivers’ behavior to be risky, and have low positive attitudes toward such vehicles when they have a stronger MV–NMV crash history. The results also suggest that bus drivers have fewer crashes with NMVs, although they feel these vehicles are structurally unsafe. In addition, age, education, and perceptions of lane separation, movement, stops, and users’ trip frequency were significant in predicting crash frequency. Further, older and illiterate drivers were more likely to be involved in collisions with NMVs. Because of the bias of self-reported data, analysis of variance tests were conducted, and the results demonstrated a significant difference in risk perceptions between motorcyclists, car drivers, and bus drivers. Risk perceptions of NMVs were the highest among motorcyclists. The findings of this study are expected to aid policymakers in improving motorists’ perceptions of NMVs and in increasing the latter’s safety in developing nations with heterogenous traffic systems.
Metro–Nonmetro Differences in Adverse Events in Residential Care Communities: Results From the National Post-Acute and Long-Term Care Study
Authors: Sengupta Manisha , Agree Emily M.
Published: November 2023

More than 1 in 5 older Americans live in rural areas (10.6 million of the 46.2 million aged 65 and older). Long-term care for aging rural populations is a growing challenge in the United States. Research on long-term care services in nonmetro areas has focused almost exclusively on nursing home care, despite growth of residential care alternatives. This paper uses unique facility-level data from the 2020 National Post-acute and Long-term Care Study (NPALS) to examine the relationship of residential care community (RCC) features in metro and nonmetro settings with adverse outcomes (emergency department visits, overnight hospital stays, and falls). Nationally, in 2020, about 13.5% of RCC residents made visits to the emergency department, 8.6% had overnight hospital stays, and 21.3% had falls. Controlling for facility characteristics, RCCs in metro areas had higher risks of overnight hospital stays ( p < .001) but lower risks of falls ( p = .06).
Classification of convertible car roofs and basics of their operation
Authors: Skowronek Hubert
Published: November 2023

This paper deals with cabrio type cars. The most interesting currently used solutions and groundbreaking designs from the last decades are presented. This paper contains collected knowledge on kinds of convertible roofs found in mass produced cabriolets. With the development of the automotive technology such constructions have evolved from simple mechanisms operated using the force of human muscles to highly complex mechatronic systems. The author introduces his own classification of car roofs with regard to their mechanical structure and the medium used to change the body status from closed to open and vice versa. In the second part of this publication the basics of the operation of car roof mechanisms are provided.
Effectiveness of Simulation Versus Video Instruction on Neonatal Resuscitation: A Randomized Control Trial
Authors: Bala Indu , Deol Rupinder , S Malar Kodi
Published: November 2023

Birth asphyxia is a major global burden in newborn health care. The high neonatal mortality rate (25.4 deaths per 1000 live births) in India necessitates the need for concrete efforts to be taken to reduce these preventable deaths. Developing competence among nurses for conducting neonatal resuscitation can improve neonatal outcomes. To flourish as skilled personnel, nursing students must be taught effectively. Video and simulation-based instruction have been reported to be effective over a chalk board for inculcating knowledge and skills among students. The primary objective of the study was to compare simulation-based teaching on neonatal resuscitation vs. video instruction among undergraduate nursing students.