bluuebunny/crossref_metadata_2025 huggingface dataset:
Phát triển tư duy phản biện trong dạy học bậc đại học
Authors: Trịnh Chí Thâm , Hồ Thị Thu Hồ
Published: June 2023

Trong nghiên cứu này, một số lí luận cơ bản về việc phát triển tư duy phản biện trong dạy học bậc Đại học được phân tích. Thông qua việc nghiên cứu tư liệu, dựa trên kết quả nghiên cứu, phản biện là một năng lực tư duy bậc cao chủ yếu dựa vào những phân tích và đánh giá thông tin một cách khách quan, có bằng chứng. Năng lực tư duy phản biện có những vai trò quan trọng gồm phát triển khả năng đưa ra quyết định, cải thiện năng lực giải quyết các vấn đề thực tiễn, tự đánh giá và chiêm nghiệm bản thân, làm nền tảng cho tư duy sáng tạo, nâng cao khả năng đương đầu và vượt qua thách thức, phát triển khả năng học tập suốt đời và hỗ trợ hoàn thiện các kĩ năng khác. Để phản biện hiệu quả, tư duy người học cần trải qua tiến trình bảy bước gồm: 1/ Tiếp nhận thông tin, 2/ Đưa ra lập luận, 3/ Tìm dẫn chứng, lí lẽ, 4/ Khẳng định lập luận, 5/ Thừa nhận, 6/ Hành động và 7/ Kiểm chứng, chiêm nghiệm.
Xây dựng chương trình đào tạo ngành sư phạm khoa học tự nhiên trình độ đại học tại Trường Đại học Cần Thơ
Authors: Huỳnh Thị Thúy Diễm , Đinh Minh Quang , Huỳnh Anh Huy
Published: June 2023

Nghiên cứu này được thực hiện nhằm mục tiêu xây dựng chương trình đào tạo (CTĐT) giáo viên thuộc chuyên ngành Sư phạm Khoa học tự nhiên (SPKHTN) trình độ đại học phù hợp với Chương trình giáo dục phổ thông môn Khoa học tự nhiên của Bộ Giáo dục và Đào tạo ban hành năm 2018 và tình hình thực tế tại các trường trung học cơ sở. Kết quả khảo sát cho thấy việc xây dựng CTĐT ngành SPKHTN là cần thiết. CTĐT đã được xây dựng với 141 tín chỉ trong đó có 108 TC bắt buộc và 33 TC tự chọn. CTĐT dự kiến này đã được các bên liên quan đánh giá phù hợp với thực tiễn. Kết quả nghiên cứu này là dẫn liệu cung cấp nhiều thông tin liên quan đến xây dựng và thực hiện chương trình đào tạo ngành SPKHTN trình độ đại học cho vùng Đồng bằng sông Cửu Long.
Một số yếu tố ảnh hưởng đến việc dạy học ngữ văn 6 theo định hướng phát triển năng lực
Authors: Phạm Văn Tính , Huỳnh Thanh Hải
Published: June 2023

Giáo dục nước ta đang trong giai đoạn chuyển mình tích cực, hướng đến việc khắc phục tình trạng dạy học truyền thụ một chiều và ghi nhớ máy móc sang chú trọng, tập trung hướng dẫn các hoạt động học, tăng cường tối đa khả năng vận dụng kiến thức đã học của học sinh vào hoạt động thực hành. Từ đó, người học phát triển năng lực và phẩm chất, đáp ứng được yêu cầu giáo dục hiện đại. Song, việc dạy học theo định hướng phát triển năng lực đối với môn Ngữ văn 6 còn gặp nhiều trở ngại, khó khăn và chưa thực sự đồng bộ. Điều này xuất phát từ nhiều yếu tố khác nhau. Qua kết quả của 106 giáo viên Trung học cơ sở đã tham gia khảo sát , nhiều yếu tố được đưa ra có ảnh hưởng đến việc dạy học theo định hướng phát triển năng lực môn Ngữ văn 6, bao gồm các yếu tố liên quan tới phương pháp dạy học, cơ sở vật chất, tâm lí người học,.. Trong bài viết này, một số yếu tố ảnh hưởng đến việc dạy học Ngữ văn 6 theo định hướng phát triển năng lực được trình bày, trên cơ sở đó, các giải pháp nhằm khắc phục những tồn tại, bất cập trong quá trình dạy và học, góp phần nâng cao chất lượng giáo dục cũng được đề xuất.
Xây dựng kế hoạch bài dạy chủ đề Ngữ văn lớp 10
Authors: Châu Kim Vàng
Published: June 2023

Xây dựng kế hoạch bài dạy chủ đề Ngữ văn lớp 10 theo định hướng hình thành, phát triển phẩm chất, năng lực học sinh là yêu cầu cần thiết đối với giáo viên. Do đó, các nội dung được trình bày trong bài viết này gồm: quan niệm về chủ đề, xây dựng chủ đề Ngữ văn; đặc điểm chủ đề; các loại chủ đề và việc xây dựng kế hoạch bài dạy chủ đề Ngữ văn lớp 10.
O agronegócio brasileiro de horticultura ornamental: um comparativo entre os censos agropecuários (2006 e 2017)
Authors: Yano Renato Rodrigues , Amorim Domingos Isaias Maia
Published: June 2023

Os valores de vendas da horticultura ornamental evidenciam a variaçãodesse importante setor do agronegócio brasileiro. O objetivo deste artigo foi avaliar o desempenho dos valores de vendas arrecadados pelos produtores brasileiros, entre 2006 e 2017, no Brasil e nas dez maiores unidades federativas em valor de venda de 2017, adentrando em cada um dos sete grupos de produtos da horticultura ornamental. Os dados foram coletados dos censos agropecuários desses dois anos, tabelados, filtrados e processados com o uso do programa “Microsoft Excel”. Os resultados mostraram que os valores de vendas da horticultura ornamental arrecadados pelos produtores têm, como um todo, crescido, porém em alguns de seus sete grupos de produtos têm ocorrido retrações. Em relação às unidades federativas, houve variação nos valores arrecadados pela horticultura ornamental e em cada um de seus produtos. Concluiu-se, portanto, que os horticultores ornamentais demonstram potencial de crescimento, que a compreensão da dinâmica desse setor do agronegócio e o fortalecimento de pontos-chave foram essenciais para sua alavancagem, para o crescimento da horticultura ornamental e dos incrementos à economia brasileira.
Fenomenología sobre la neuroeducación en el subnivel de preparatoria: concepciones del profesorado
Authors: Loor-Llanos Lilian , Torrealba Peña Mairelys
Published: June 2023

El objetivo de este estudio fue identificar las concepciones sobre la aplicabilidad de la neuroeducación en las prácticas pedagógicas de los docentes del subnivel preparatorio de educación general básica adscritos a un centro educativo fiscal de Ecuador. Su importancia radica en la potencialidad de la neuroeducación en redireccionar el trabajo pedagógico en provecho de una formación humanista. La investigación se abordó bajo un paradigma interpretativo, manteniendo un enfoque cualitativo y el método fenomenológico. Se utilizó la entrevista semiestructurada, basada en un guion. Se aplicó el proceso de categorización a los testimonios de las doce docentes informantes clave, de donde emergieron las siguientes categorías: “Neuroeducación como paradigma nuevo de enseñanza”, “Personalización de la educación” y “Estrategias didácticas centradas en el estudiante”, esta última con las subcategorías: “Impulso de la gestión emocional” y “Fomento de actividades artísticas”. La triangulación teórica (Martínez, 2007) evidenció que la neuroeducación, desde la óptica de los entrevistados, alude a metodologías didácticas que estimulan la participación creativa, espontánea y amena de los estudiantes, apoyándose en la creación de experiencias educativas basadas en la inteligencia emocional, el juego, el arte y la reducción de cualquier estado emocional que interfiera con el desarrollo holístico de los estudiantes.
Experiencias de aprendizaje y expectativas académicas en universitarios mexicanos durante la COVID-19
Authors: Gaeta Laura , Rodríguez Guardado María del Socorro , Gaeta Martha Leticia , Malpica Olga
Published: June 2023

En este estudio se analizaron las experiencias de aprendizaje y las expectativas académicas de estudiantes universitarios mexicanos durante la educación remota de emergencia, aplicada en el segundo año de distanciamiento social por la COVID-19. Se realizó un estudio cualitativo basado en entrevistas semiestructuradas a 21 estudiantes, 10 mujeres y 11 hombres, de licenciatura (57.1 %) y de posgrado (41.9 %) de tres universidades. Los resultados indican que el aprendizaje en línea fue una experiencia agotadora y desafiante para el estudiantado, que implicó procesos de gestión personal, del ambiente y de los recursos. Las y los estudiantes valoraron los ajustes instruccionales y de evaluación del profesorado, pero destacaron la falta de socialización como un aspecto sustancial en sus experiencias de aprendizaje. Además, manifestaron optimismo para continuar sus estudios a la luz de sus expectativas. Sin embargo, consideraron que su preparación académica se  vio mermada, lo cual puede tener implicaciones para su futuro desempeño académico y profesional.
Dark Web and Law Enforcement the Never-Ending Battle
Authors: Bagle Shobha
Published: June 2023

Abstract: What is the Web? Is it Google? Or, Facebook? Emails, messenger, Yahoo? Well, these and all other forms that we are aware of barely constitute 4% of the whole world wide web! So, are we just looking at the tip of the iceberg? What constitutes the remaining 96% of the web? Let’s understand what 96% of our web consists of, there are 3 layers of the web 1) Surface Web 2) Deep, Web and 3) Dark Web .4% of the web that we use on a daily basis consists of the Surface Web which includes our Google, Facebook, WhatsApp, etc. The remaining 96% consist of Deep Web and Dark Web. Deep Web. As the name Dark Web the word Dark actually refers to secrets stored in dark, crime, illegal activities, and creepy things. Dark Web ca n be accessed through TOR (Onion Router). According to the statistics, the US citizen accounted for 34.81% of the Dark Web daily user count. It translates to 831,911 users. Russia took second place with 11.46%, and Germany ranked third with 7.16% of total active users. These are the statistics calculated for the year 2020
A Comprehensive Review on Association Rule Mining and its Algorithms: Apriori, FP Growth, and SS-FIM
Authors: Vashi Priyankaben
Published: June 2023

Abstract: The technique of extracting usable information from databases is known as data mining. It is employed to manage massive amounts of data. In order to forecast future trends and behaviours, data mining is performed. Today, data mining is a technique that is growing helpful since it has many uses. Massive amounts of data are produced daily in many different fields. Data mining is utilised since it is challenging to analyse such a big volume of data. It is often referred to as database knowledge discovery (KDD). Data mining technologies are used to forecast the behaviour and pattern of the data, assisting organisations in decision-making [1]. Association Rule Mining is one of the data mining techniques discussed in the present article. It has three algorithms. 1. Apriori, 2. FP-Growth, and 3. SS-FIM. In the current work, all three algorithms are discussed. After examining each algorithm, it was determined that the SS-FIM algorithm had the best combination of features
Performance of Regenerative Air Preheater of Pulverized Coal Fired Boilers
Authors: Kumar M. Ravi
Published: June 2023

Abstract: The air preheater (APH) is the final heat trap in the boiler's flue gas path. Effective pre-combustion coal drying and efficient combustion in the boiler are required for APH to operate efficiently. The effectiveness of heat transfer in APH is significantly influenced by the characteristics of relative humidity and ambient air temperature (AAT). Relative humidity (RH) and air density are also impacted by variations in AAT, which in turn alters the heat capacity of the air. If there is insufficient reserve heat exchange capacity in APH, an increase in AAT will diminish the possibility of waste heat recovery. Additionally, a change in AAT will affect the power consumption of the fans and the leakage through various seals.
A Survey on Smart Switches used in Home Automation
Authors: Mirikar Sakshi
Published: June 2023

Abstract: IOT is playing in very important role in the current digital world. Everyone wants to live a digital life, in which digitalisation and internet of things is the main concept which can be used and implemented to live a digital life. In this paper we will be studying about the smart city concept which includes home automation concepts in which smart switches are used. Everyone wants a smart home, but as home being smart also comes with a great cost being implemented for the smartness. Speaking of the sensors actuators devices, which will be including for building a smart home.
Study on Bio-remediation of Oil Contaminated Sand
Authors: Vignesh K. S.
Published: June 2023

Abstract: The consumption of oil is getting raised day to day in our country. Its availability is limited to only a few countries. So, it has to be transported from such countries to other parts of the world. Leakage of oil occurs during drilling process and transportation through pipe lines. Due to this leakage the surrounding sand or water gets contaminated. Because of this, contamination sand is getting polluted and its engineering properties are altered. This study is carried out to determine the effects of crude oil contamination on the engineering properties of sea sand and to improve the properties of oil contaminated sea sand by the process Bioremediation. The soil samples are collected from Ganagalla Peta Beach, Andhra Pradesh. The samples are then artificially contaminated using crude oil in varying percentages of 2%, 4%, 6%, 8%, 10% and 12% for 2, 7 and 14 days. Sea sand is considered for this study. The laboratory tests such as direct shear, Standard proctor and chemical analysis was carried for both contaminated and bioremediated sand. As the bioremediation improves the shear strength of the soil, it is carried out for contaminated sand by using bacteria Bacillus amyloliquefaciens as it removing hydrocarbons from the contaminated sand. The Engineering properties of bioremediated sand are compared with contaminated sand
Soil Stabilization by Using Lime and Fly Ash at Ahirwadi
Authors: Bhosale Harshad
Published: June 2023

Abstract: Soil stabilization is a crucial aspect of civil engineering, particularly in the construction of infrastructure projects. This study investigates the effectiveness of lime and fly ash as soil stabilizers and their combined application for enhancing soil properties. The objective of this research is to evaluate the changes in the geotechnical properties of soil treated with lime and fly ash, including compressive strength, shear strength, and durability. In this experimental study, different proportions of lime and fly ash were mixed with the soil samples to determine the optimal combination that yields the highest improvement in soil characteristics. The laboratory tests conducted on the stabilized soil samples included compaction tests and unconfined compressive strength tests. The samples were cured for different periods to assess the long-term performance and durability of the stabilization technique. The results indicate that the addition of lime and fly ash significantly improves the soil's engineering properties. The lime effectively increases the soil's pH, reducing plasticity and improving workability. The fly ash, on the other hand, enhances the pozzolanic reactivity and improves the soil's strength and durability. The combination of lime and fly ash demonstrates synergistic effects, leading to further improvements in the stabilized soil's properties.
Green Audit in Nanasaheb Mahadik College of Engineering, Peth
Authors: Bhosale Harshad
Published: June 2023

Abstract: A clean and healthy environment aids effective learning and provides a conducive learning environment. There are various efforts around the world to address environmental education issues. Environmental Management Systems (EMS) is very popular in the industrial sector, but the general belief is that EMS is something pertaining to industries only. Other parts of the world have started adopting compatible environmental management systems either voluntarily or by promoting standards by external certification. International environmental standards do not suit the existing Indian educational system. A very simple indigenized system has been devised to monitor the environmental performance of educational institutions. Reduction in resource uses Financial savings through a reduction in resource use Curriculum enrichment through practical experience Development of ownership, personal and social responsibility for the college and its environment Enhancement of college profile Developing an environmental ethic and value systems in young people.
Seismic Analysis and Design of Elevated Circular Water Tank for Variation of H/D Ratio and Bracing Patterns
Authors: Ugemuge Manali
Published: June 2023

Abstract: Seismic analysis and design of elevated circular water tanks play a crucial role in ensuring the structural integrity and safety of these essential infrastructure components. This study focuses on investigating the effects of varying the height-todiameter (H/D) ratio and different bracing patterns on the seismic performance of such tanks. The analysis procedure includes a comprehensive numerical investigation using finite element analysis (FEA) software. The elevated circular water tank models are subjected to various seismic loading conditions to evaluate their dynamic response. Different H/D ratios are considered to assess their influence on the tank's behavior under seismic excitation. Additionally, the study explores the impact of different bracing patterns on the tank's seismic resistance. Various bracing configurations, such as radial, circumferential, and combined patterns, are investigated to identify the most effective design approach for mitigating seismic forces.
Trait Self-Control Memoderasi Pengaruh Fear of Missing Out terhadap Prokrastinasi Akademik
Authors: Balqis Audita Izza , Citra Andina Putri
Published: June 2023

Social media has grown rapidly giving an impact on academic activities. Fear of missing out (FoMO) is a phenomenon that develops due to the use of social media, which is thought to be a contributor to academics. This study aims to determinethe effect of FoMO on academic procrastination by considering the role of the trait of self-control. 116 participants ﬁlledout online questionnaires to measure the Academic Procrastination Scale (APS), Brief Self-control Scale (SCS), and Fear of Missing Out Scales (FoMOS). Data analysis was carried out using the moderating regression method, showing that the trait of self-control signiﬁcantly moderated the effect of FoMO on academic procrastination. This study implies that the self-control trait can be used as a reference in reducing the level of academic procrastination.
Factors Hindering Elimination of Mother to Child Transmission of HIV Service Uptake among HIV Positive Women at Comboni Hospital Kyamuhunga Bushenyi District
Authors: Viola Nankya , Kimono Esther , Nuruh Ndagire , Obeagu Emmanuel Ifeanyi
Published: June 2023

In the absence of preventive measures HIV infected mothers transmit the infection to their babies during pregnancy delivery and breastfeeding. However, improving eMTCT service uptake and continuum of care still remains a significant impediment in the western region of Uganda. The study was to explore factors hindering eMTCT service uptake among HIV positive women at Comboni Hospital Kyamuhunga. A descriptive cross-section design was used and majorly simple random sampling was employed with a number of 36 respondents and interviewed response were analysed using SPSS version to determine the association between the independent and dependent variable.
 The findings of the study revealed that there are a range of factors that hinder HIV positive women on eMTCT service uptake, disclosure of HIV status with 77.7%, lack of partner and family support with 75%, dependence on partners with 80.6%, long waiting times at facility and no linkage to support groups with 33.3%and 47.2% respectively.  In conclusion Strengthening community awareness on the importance of eMTCT service uptake, improving on time management by health workers, engaging male involvement in eMTCT care, improve youth friendly services, empowering women, putting emphasis on disclosure of status and supporting young mothers is so crucial.
Keywords: elimination, mother to child transmission, HIV service uptake, HIV positive women
Histopathological and Biochemical Effect of Vitamin C and D on Phosphine-Induced Hepatotoxicity in Wistar Rats
Authors: Akinpelu Moronkeji , Gamade Solomon Matthias , Akinbo Frederick , Adeniyi Temidayo Daniel , Elizebeth Adebowale Funmilola , Obeagu Emmanuel Ifeanyi
Published: June 2023

Background: Aluminum phosphide is becoming a very common agent for self-poisoning. The lack of specific antidote for phosphide poisoning has aroused the current interest of research.
Objectives: This study aimed to investigate the possible protective effect of Vitamin C and D in phosphine-induced hepatotoxicity in Wistar rats.
Methods: In this experimental study, 20 Wistar rats were randomly divided into five groups ( n = 12). Group I was apparently normal Control Group. Groups II-V were induced with 2.5 mg/kg ALP. Groups II was without further treatment while Groups III-IV received vitamin C at 100mg/kg/bw and vitamin D at 10mg/kg/bw. Group V was co-administered with vitamin C at 100mg/kg/bw and vitamin at 10mg/kg/bw. The treatments lasted for 28 days.
 Results: The results showed that Vitamin C and D (P<0.05) increased antioxidant capacity. Combined active constituents of the Vitamin C and Vitamin D raised the GPX antioxidant activities when compared to the phosphine poisoned group treated individually with Vitamin C and D. The combined activities of Vitamin C and Vitamin D showed the highest antioxidant effect as compared with the control  
Conclusion: The combined activities of Vitamin C and D supplementation improved the antioxidant defense system and histology of the liver in phosphine poisoning.
Keywords: Metal phosphide, Carotene, Liver cell damage, Poison
Chewing yam fruit (Pachyrhizus erosus) as an effort to reduce index debris in elementary school children
Authors: Fadjeri Indrayati , Dzulfaqor Afna , Purnama Tedi
Published: June 2023

Oral health is an integral component of general health. The prevalence of dental caries in Indonesia is around 90% of the 238 million Indonesian population and the number of children aged 15 years and under who suffer from dental caries reaches 76.5%. Eating fibrous foods such as fruits can help clean teeth, one of which is yam fruit. The purpose of this study was to determine the debris index score before and after eating yam in elementary school children. This research method is quasi experimental. This research was conducted with a population of 61 students obtained by using a total sampling technique. The instrument used in this study was a debris index examination sheet. Results: before eating yam fruit, 3 students (4.9%) had good index debris criteria, 28 students (45.9%) moderate index debris criteria, 30 students (49, 9%) had bad index debris criteria (49, 2%) and after chewing yam fruit, 47 students (77%) had good debris index criteria, 14 students (23%) had moderate debris index criteria and there were no students with bad index debris criteria. The results of the paired sample test analysis obtained a p-value of 0.001. Conclusion: Chewing yam fruit can reduce index debris in elementary school children.
Keywords: Chewing yam fruit, index debris, children
Relationship between family history, diet and sedentary behavior with the incidence of diabetes mellitus
Authors: Sudrajat Ace , Romadhona Maharani , Manurung Santa , Suratun Suratun , Yardes Nelly , Lusiani Dewi , Hartini Tin
Published: June 2023

Diabetes Mellitus (DM) is a degenerative disease that is a public health problem throughout the world. Diabetes mellitus has become one of four non-communicable diseases that will cause around 6.7 million people to die in 2021. Currently, the number of cases and prevalence of diabetes mellitus continues to increase. There are several risk factors that can cause diabetes mellitus, including family history, food patterns and sedentary behavior. This study aims to determine the relationship between family history, diet and sedentary behavior on the incidence of diabetes mellitus. The population in this study were all patients aged 45- 75 years who were treated at the Chronic Disease Management Program (Prolanis), Public Health Rebo District Market Center. Samples were taken as many as 68 respondents with a purposive sampling technique. The data was collected using a questionnaire and then analyzed using the chi square test. The results showed that there is a relationship between family history (p-values = 0.003 with OR = 5.061), diet (p-values = 0.002 with OR = 5.667) and sedentary behavior (p-values = 0.011). with OR value = 3829) with the incidence of diabetes mellitus
Keywords: Family History, Food Patterns, Sedentary Behavior, Diabetes Mellitus, Incidence
Doxorubicin layer-by-layer nanoparticles for controlled delivery and effective treatment of pancreatic cancer
Authors: Rawal Vinni , Joshi Hricha , Gangwar Poonam , Dixit Anjali , Tiwari Neha , Nigam Parul , Kumar Pramod
Published: June 2023

Introduction: Layer-by-layer (LbL) nanoparticles consist of a versatile drug delivery technique, for targeted and controlled delivery. The Doxorubicin (DRC) is being widely used for treatment of pancreatic cancer (PCR). The present study was performed to develop and evaluation LbL nanoparticles (NP’s) of DRC to provide controlled and targeted delivery for effective treatment of PCR.

Materials and Method: A liposomal based polymeric pH sensitive NP’s were prepared by utilizing LbL techniques. The NP’s were composed lipids, poly (b-amino ester) (PAE) and hyaluronic acid (HAC). The physiochemical properties of DRC-LbL NPs was evaluated such as particle size, zeta potential, percent entrapment efficiency (%EE), loading of drug and In-vitro drug release behavior. The surface morphology of LbL NP’s was evaluated by scanning electronic microscopy (SEM).  The in vitro release of DRC-LbL-NP’s was determined by using Dialysis technique at pH 5 and 7.

Results: Results showed that developed DRC-LbL NP’s  having average particle size of 182.94 + 4.11 nm, zeta potential (ZP) of -42.78± 3.2mV, higher drug entrapment efficiency (EE) of 74.94±3.45. The in-vitro drug release from DRC-LbL NP’s exhibited sustained release pattern and it was triggered by lower pH. The surface morphology of developed DRC-LbL NP’s exhibited smooth and uniform particle size in nano range. The results from in-vitro drug release showed that there was significant difference in amount of DRC release in both pH media. In phosphate buffer pH 7.4 the total amount of DRC release was found to be 44.82 % after 48 hour of study whereas in pH 5.0 it was recorded 98.24% after 48 hours.

Conclusion: The results from present study conclude that DRC-LbL NPs might be a promising candidate for the effective treatment of pancreatic cancer.

Keywords: Layer-by-layer, Nanoparticles, Doxorubicin, Controlled delivery, Targeted Delivery
Acemetacin in Acute and Chronic Pain Management
Authors: Berk Barkin
Published: June 2023

Acemetacin is the carboxymethyl ester of indomethacin and is a pro-drug precursor compound, in other words, a prodrug. The pharmacologically active metabolite of acemetacin is also indomethacin. Acemetacin exerts its potent non-steroidal anti-inflammatory effects in the body as indomethacin. It is known that acemetacin is not only a prodrug of indomethacin, but also an agent with gastric protective mechanisms, possibly involving a reduction in leukocyte adhesion, and that acemetacin exerts gastric protective effects by exhibiting less efficacy on the COX-1 enzyme in the gastric mucosa compared to direct indomethacin use. It is clear that acemetacin is a valuable NSAID for acute and chronic pain.

Keywords: Acemetacin, indomethacin, non-steroidal anti-inflammatory drugs.
Comprehensive Assessment of Transcorneal Permeation, Antimicrobial, and Antifungal Activities of Andrographolide-Loaded Nanosuspension: In vitro and In vivo Studies
Authors: Mansuk Avinash G. , Pachpute Tejas S.
Published: June 2023

This study aimed to comprehensively assess the transcorneal permeation, antimicrobial, and antifungal activities of a nanosuspension loaded with Andrographolide, a promising herbal compound. Through a combination of in vitro and in vivo studies, the efficacy, and potential applications of the nanosuspension in ocular drug delivery were investigated. In the in vitro phase, transcorneal permeation studies were conducted using Franz diffusion cells with excised rabbit corneas. The nanosuspension demonstrated significantly enhanced permeation compared to a control formulation, indicating its ability to effectively deliver Andrographolide through the cornea and into the ocular tissues. Additionally, the nanosuspension exhibited potent antimicrobial and antifungal activities against various ocular pathogens, as determined by agar diffusion and broth microdilution assays. Building upon the promising in vitro results, in vivo studies were performed using a rabbit model. Ocular tolerability of the nanosuspension was assessed through eye observations, with no observed signs of irritation or adverse effects. Furthermore, the nanosuspension's in vivo antimicrobial and antifungal activities were evaluated by instilling the formulation into the rabbits' eyes and monitoring conjunctival congestion and inflammation. The results demonstrated a significant reduction in conjunctival congestion, highlighting the nanosuspension's potential for combating ocular infections and inflammation. The comprehensive assessment presented in this study establishes the transcorneal permeation capability of the Andrographolide-loaded nanosuspension and its remarkable antimicrobial and antifungal activities. These findings underscore the potential of the nanosuspension as an effective ocular drug delivery system for various ocular infections and inflammatory conditions. The study contributes to the development of novel therapeutic approaches in ophthalmology, aiming to improve patient outcomes and provide alternative treatment options for ocular diseases.

Keywords: Transcorneal permeation; Nanosuspension; Andrographolide; Antimicrobial activity; Antifungal activity; Ocular drug delivery
Formulation and Evaluation of New Sustained Release Floating Microspheres of Cilnidipine by Solvent-Diffusion Evaporation Technique
Authors: Sharma Kritika , Thakur Priya , Agarwal Shweta
Published: June 2023

The purpose of the present investigation was to develop a gastro-retentive cilnidipine loaded floating microspheres. The floating microspheres of cilnidipine were prepared by the solvent evaporation method for oral drug delivery using HPMCK4M and ethyl cellulose as polymers. The drug loaded microspheres were evaluated for particle size, drug content, entrapment efficiency and floating time. The in-vitro study was performed in pH 1.2 to determine the amount of drug released. Field emission scanning electron microscopy (SEM) was performed to check the surface morphology of microspheres. The mean particle size of the microspheres was in the range of 226.85 – 339.42µm. The drug content of the floating microspheres was more than 70% and drug entrapment efficiency of microspheres obtained between 64.64 – 83.0%. The in-vitro buoyancy was more than70%. Cumulative % of drug release obtained between 73.12 – 89.68%. Field emission scanning microscopy results showed that the prepared microspheres were smooth and spherical.The study reveals that more the particle size extended the floating time, this methods reveals that the drug content  of the microspheres enhanced as the amount of polymer increased or increased in ethyl cellulose concentration also leads to increase in entrapment efficiency and particle size. Cumulative % drug release decreased as ethyl cellulose concentration increased.

Keywords: cilnidipine, microspheres, floating drug delivery system, entrapment efficiency, cumulative drug release, ethyl cellulose, Field emission scanning electron microscopy, polymer, concentration
Dental health education: Maintenance of dental health using flipchart media
Authors: Emini Emini
Published: June 2023

Background: Dental and oral health maintenance is an effort to improve health. One of the reasons a person ignores dental and oral health problems is the lack of knowledge about dental and oral hygiene. Provision of dental and oral health knowledge should be given to school-age children. Efforts to increase knowledge are dental health counseling using flipchart media. Purpose: to analyze knowledge of dental and oral health maintenance before and after being given counseling using flipchart media for fifth grade students at SDN Tidung Island, 2022. Method: Pre-experimental research with pretest-posttest one group design. This research was conducted on 69 students of class V SDN on Tidung Island, who were obtained using a total sampling technique. The research instrument used a questionnaire and data analysis used the descriptive analysis. Results: The correct answers to the pre-test questions in the good category were 32 students with a percentage of 46.4%, in the sufficient category were 26 students with a percentage of 37.7%, and in the poor category were 11 students with a percentage of 15.9%. While the results of the correct answers to the post-test questions in the good category were 64 students with a percentage of 92.2%, the sufficient category was 5 students with a percentage of 7.2%, and the poor category was 0 with a percentage of 0%. Conclusion: there is a change in students' knowledge after being given dental health education using flipchart media.

Keywords: flipchart media, knowledge, dental health education.
Development and Validation of Stability Indicating Assay Method of Doxycycline Hyclate by using UV-Spectrophotometer
Authors: Sahoo Pradyumna Kumar , Sahoo Padmabhusana , Mohapatra Jagannath , Panigrahi Debadash , Patra Anup Kumar , Mishra Amiyakanta
Published: June 2023

In the present study a simple, rapid, sensitive, and cost-effective stability indicating UV- spectrophotometric method was developed of doxycycline hyclate in bulk form and validated as per ICH guidelines. The stability-indicating study of doxycycline hyclate was based on the forced degradation reactions of the drug under different ICH-prescribed stress conditions like acid, alkali, neutral, oxidation, thermal, and photolysis.  The absorption maximum of the drug was shown at 270nm and methanol was selected as solvent on the basis of the solubility of the drug. A linear relation with a regression coefficient value (R2) of 0.999 indicates that the method follows Beer’s- Lambert’s law within the concentrations range of 5 - 50µg/ml.  The detection limit and quantitation limit were found to be 0.53 µg/ml and 1.55 µg/ml respectively. The % of recoveries was found to be within the range of 98.87 -99.88 with a low % of RSD indicating the accuracy of the method for estimation of the drug. Under stressed conditions, significant degradation was found in alkali, neutral and oxidation conditions and found to be sensitive under thermal and photolytic conditions but stable to acidic hydrolytic conditions. The developed method was validated according to ICH guidelines and found accurate, precise, and specific, suggesting that the developed stability-indicating spectroscopic method could be successfully adopted to estimate doxycycline hyclate.

Keywords: Doxycycline Hyclate; Stability Indicating method; UV spectrophotometer; Validation; Stress degradation.
Phytochemistry, Pharmacology and Unani traditional uses of Kasni (Cichorium intybus Linn.): A Review
Authors: Khatoon Shamshiya
Published: June 2023

Kasni (Cichorium intybus Linn.) is highly praised in many traditional systems of medicine for medicinal properties of its leaves, seeds and roots. It is grown in Punjab, Kashmir, Andhra Pradesh, Karnataka and Maharashtra. In traditional medicine, all parts of the plant are used as diuretic, laxative, antibilious, antipyretic, blood purification, appetizer and strengthen of the stomach. It is also used in the treatment of hepatic failure, jaundice, intermittent fever and mild states of chronic skin diseases. It contains glycosides, flavonoids, saponins, caffeic acid derivatives, inulin, lactucin, sonchuside A, cichoriolide. The scientific analysis of kasni demonstrates many of the activities mentioned in Unani literature. Nevertheless, further research is needed to identify the mechanism, active constituent, and usefulness of kasni in clinical practice. Given the encouraging results against neurological disorders in the prefaces, this aspect should be thoroughly investigated to make it a standard medicine.

Keyword: Kasni; Hepatoprotective; Unani medicine; esculatin
Formulation and Evaluation of Oral Soft Jelly Containing Salbutamol Sulphate for the Treatment of Asthma
Authors: Honale Vaishnavi Sanjay , Muneshwar Shraddha Dilip , Sawale Amol V
Published: June 2023

Salbutamol sulphate oral soft jelly in asthma has been formulated and evaluated as the goal of the current investigation. A person with asthma has inflamed, narrowed, swollen, and excess mucus-producing airways, which makes breathing difficult. Salbutamol is used to treat asthma and chronic obstructive pulmonary disease (COPD.It works by relaxing the muscle of the airways into the lungs, which makes it easier to breathe . It functions by loosening the muscles in the lungs' airways, which facilitates breathing. Salbutamol is available as an inhaler, tablets, and certain liquid oral dose forms, but due to patient noncompliance issues, oral jellies containing salbutamol sulphate were developed. This study's aim is to create oral jelly, which by avoiding first pass effect, promotes patient compliance and bioavailability while avoiding many negative effects of conventional dosage forms Salbutamol sulphate oral jelly is simple to swallow and improves patient compliance in paediatric patients. Many paediatric patients find it difficult to swallow tablets and capsules, as well as to use the salbutamol inhalation in cases of asthma. The best In vitro medication release was demonstrated by the salbutamol sulphate oral jelly (F2) batch at 85% in 60 minutes. The drug concentration was discovered to be between 98.23% and 99.25%, which was within the pharmacopoeial range of 98% to 101%. Salbutamol sulphate's UV spectra were examined, and it was discovered that its greatest absorption occurs at 217.50 nm. The cost-effective salbutamol sulphate oral soft jelly also demonstrated improved compliance and an increase in bioavailability.

Keywords: Oral Jelly, Asthma, Patient Compliance, Salbutamol Sulphate, Paediatric Patients
Evaluation of Anti-Diabetic Activity of Silver Nanoparticles Synthesized from Ethanolic Extract of Phyllanthus niruri on Wistar Rats
Authors: Kotaru Manvitha , Korimelli Sridevi
Published: June 2023

Diabetes is a metabolic disorder characterized by hyperglycemia resulting from either the deficiency in insulin secretion or the action of insulin Diabetes can affect numerous different organ systems in the body and, over time, can lead to serious complications. Complications are microvascular or macrovascular. To evaluate the anti-diabetic effect of Phyllanthus niruri silver nano-particles. Streptozotocin (STZ) of 50mg/kg is used to induce diabetes in wistar rats. The wistar rats were distributed to six different groups. Group-I represented as Control; Group-II represented as diabetic control (STZ ); Group-III represented as 5 mg/kg body weight of glibenclamide + diabetes; Group-IV represented as  phyllanthus niruri extract + diabetes; Group-V represented as 100 µg Phyllanthus niruri silver nanoparticles + diabetes; group-6- Phyllanthus niruri silver nanoparticles150µg + diabetes. The silver nanoparticles were inspected for the morphological and optical properties investigated using UV spectrophotometer, SEM and FT-IR techniques.  The AgNPs has shown characteristic peak at 428nm.The study revealed that the AgNPs treatment reduced serum blood glucose concentrations remarkable improvement in the body weight, Abnormal high serum levels in diabetes treatment with AgNp’s they reached to normal in STZ-challenged diabetic rats. The histo-pathological alterations were also studied in all the experimental animals.  The pathology results revealed that the AgNPs treatment induces the regeneration of islets cells of pancreas in the experimental rats. The research study proved that the Phyllanthus niruri AgNPs exerts anti-diabetic properties.

Keywords: Diabetes, STZ, Phyllanthus niruri, silver nanoparticles
Glucose adsorption capacity and inhibitory potential of Pseudocedrela kotschyi (Schweinf.) Harms (Meliaceae) leaf extracts against α-amylase: a comparative study over three months
Authors: SANOU Yacouba , OUATTARA Lassina , KABRE Pawendé , OUEDRAOGO Relwendé Justin , OUOBA Paulin , ZANTE Abdoul Aziz , ZOUNGO Daouda , SOMDA Martin Bienvenu , OUEDRAOGO Anicet Georges
Published: June 2023

Objective(s): The aim of this study was to evaluate the antidiabetic potential of Pseudocedrela kotschyi leaf decoction by making a comparison between extracts harvested over three months.

Design: This study is done through a few experiences. After the quantification of total polyphenols by folin-Ciocalteu reagent method, the antioxidant activities were tested with ABTS, DPPH and FRAP essays. Then, the glucose oxidase kit was used to determine the glucose adsorption capacity of the extracts. At last, dinitrosalicylic acid method served to evaluate the α-amylase inhibitory activity of the extracts.

Results: As results the leaves extracts of Pseudocedrela kotschyi  showed a polyphenol content of 39,97 ± 3,63 mg EAG/g DE for October, 74,2 ± 11,64 for November and 59,45 ± 7,024 for December. For total flavonoids, the content was 4,86 ± 0,29 mg QE/g DE (October) 5,68 ± 0,39 mg QE/g DE (November) and 5,548 ± 0,19 mg QE/g DE (December). In addition, the antioxidant activity was correlated with the phenolic content (r = -0.65 for DPPH IC50, r = -0.84 for ABTS IC50 and r = 0.97 for FRAP). Besides, the extracts exhibited a strong α-amylase inhibitory activity (IC50 = 0,272 mg DE/mL for October, 0,097 mg DE/mL for November and 0,101 mg DE/mL for December) and had a high capacity to adsorb glucose (over 219,98 ±2,54mmol/g DE for a 30mM glucose solution for November).

Conclusion: Pseudocedrela kotschyi leaf decoction has the ability to inhibit α-amylase activity and adsorb glucose in glucose concentrated solution. So it possess a high antidiabetic potential.

Keywords: Glucose adsorption, α-amylase, Pseudocedrela kotschyi, antioxidant activity.
Investigation of the Effect of Quercetin in Experimental Ischemia-Reperfusion Injury Model in Rat Testicle
Authors: Gezer Rabia , TUNCER Mehmet Cudi , KASIRGA Zeynettin , DEVECİ Engin , Aşır Fırat
Published: June 2023

Testicular torsion (TT) is the most important cause of acute scrotum in childhood. It is an emergency surgical problem that can lead to loss of organ if left untreated. The aim of treatment is to reduce or eliminate the torsion/detorsion damage. The affect of antioxidants is one of the methods to be used for this reason. In this study, a special bioflavonoid and quercetin, an antioxidant known to protect against oxidative damage, were used to avoid experimentally caused torsion/detorsion damage in rats.

32 male Sprague Dawley rats, 12 weeks old, weighing 250–300 g, were used in the study.Rats were randomized into 4 groups. No surgical procedure was performed in the control group. 5-hour ischemia was achived by applying torsion to the left testicle in the torsion group. After 5 hours of ischemia, a 2-hour reperfusion was applied in the torsion/detorsion group. In the torsion/detorsion+quercetin group, 2 hours of reperfusion was applied after 5 hours of ischemia and i.p. quercetin was injected.

 A significant decrease was observed in the quercetin-administered group in terms of spermatocyte degeneration and inflamation. There was a decrease in dilatation data in the quercetin group, but it was not statistically significant.

Quercetin, which has a strong antioxidant effect, has been shown to have positive effects on experimentally induced torsion/detorsion damage.

Keywords: Testicular torsion, ischemia-reperfusion, antioxidan, quercetin, Inflammation
Investigation of The Hamstrıng/Quadriceps Ratio, Time to Peak Torque and Joint Angle at Peak Torque Characteristics of Female Soccer Players
Authors: APAYDIN Necdet , İNCE Alparslan
Published: June 2023

It is thought that time to peak torque and joint angle at peak torque parameters provide important data for the functional evaluation of quadriceps and hamstring muscles. It is known that studies with these parameters are rare in the literature. The aim of this study is to investigate the relationship between hamstring/quadriceps (H/Q) ratio, time to peak torque and joint angle at peak torque parameters of female football players. The sample group of the study consisted of 20 female footballers performing in the national women's league (3rd Division). Measurements of the footballers’ knee joints, as 60°/sec. and 180°/sec. angular velocities were performed with the concentric/concentric protocol. The conformity of the data obtained from the footballers to the normal distribution was analized with the Shapiro-Wilk Test and it was determined that they showed a normal distribution. Relationships between parameters were analyzed with Pearson correlation coefficient. According to the results of the analysis, it was determined that there is a statistically significant relationship between the non-dominant 180°/sec H/Q ratio and the time to peak torque of the flexor muscle at 180º/sec angular velocity, and between the dominant 180°/sec H/Q ratio and the joint angle at peak torque 180°/sec flexion. (p0.05). As a result, it can be said that the H/Q ratios of female football players are not related to functional strength parameters (time to peak torque and joint angle at peak torque) and functional performance should be evaluated with different approaches.
Princípios psicanalíticos: de entradas e variedades casuais
Authors: Alves da Silva Filho Estanislau , Ramos Estevão Ivan
Published: June 2023

Quis-se, no presente livro, realçar considerações sobre variados começos de tratamentos, mais ou menos analíticos, isto é, importava menos se o fossem. Importava mais como horizonte ou como conversa, o tal analítico – ainda que pudesse emergir como eixo pivô também. Mas, daí o convite às autorias, para que nos falassem das suas diversidades práticas, de princípios e encaminhamentos reversos, cada um a seu modo e a seu contexto. Por vinheta e só vinheta, mais denso em teoria, se dedicado ao além-consultório, certamente para mais que a dita ‘prática comum’ – se é que haveria isso (há prática, agora, “comum” é outra história) –, tudo isso fora convocado. Começos de relações terapêuticas, é disso que se trata, se faz o tratamento. Ou mais bem, é isso que se traz. Por ensaio, reflexão, contação e teorização. Então, assim, aqui: ensaiam: Talita Minervino e Luiz Eduardo; clinicam: Victória Kniest, Luiza Azem, Carina Cruvinel e Karina Destro; densificam em extensão: Cirlana Rodrigues, Gabriel Binkowski, Clarice Paulon, Julia Bartsch, Aline Accioly, Augusto Coaracy e Mayara Pinho; em teoria e tese, Estanislau Alves, Enzo Pizzimenti e Andressa Dumarde. Mas a separação é mentira: tudo se mistura, em forma e conteúdo. Um conjugado interessantíssimo e instigante, capaz de efeito caleidoscópico, de impressionar: entrelinhas, entrelaços, interpenetrações e cruzamentos. É mesmo como se uma coisa se transformasse em outra e isso levasse a mais transformações. Em suma, enfim, dedica-se tal empreendimento ao leitor que agora, esperamos, possa ser transformado desigualmente.
Modeling of pipeline transportation facilities based on remote sensing data
Authors: Dolgopolov D.V.
Published: June 2023

The author considers the results of geospatial modeling of a production facility based on data from various types of surveys obtained during monitoring. The essence is to combine it in a single coordinate space for subsequent modeling with remote methods. The technological solutions are described; they enable performing geospatial modeling of pipeline transport objects on the basis of a single coordinate space due to the data from various types of remote studies. The site of the oil refinery, where reconstruction must have been carried out, was chosen as the object of the research. The remote sensing data were obtained through ground-based laser scanning and digital aerial photography using a drone. A scheme for remote sensing, information preprocessing and geospatial modeling of pipeline transportation facilities is provided. As a methodological basis for geospatial modeling, constructive methods are used, assuming the finiteness of the elements and the use of its basic components as an information unit.