bluuebunny/crossref_metadata_2025 huggingface dataset:
Kemampuan Berpikir Kreatif Siswa dalam Pemecahan Masalah dengan Konteks Covid-19
Authors: Wulandari Julia Ayu , Siswono Tatag Yuli Eko
Published: September 2021

This study aims to describe the creative thinking abilities of students based on their level of creative thinking in solving math problems in the context of covid 19. Data collection was carried out by providing a test for solving mathematics problems in the context of Covid 19. Data analysis techniques were data reduction, data presentation, and conclusion drawing. Data analysis is to see how the student is solving problems with what ideas can be given. The research subjects were four students with different levels of creative thinking, then interviewed how the students completed these problems. The results showed that the subject at level 0 (not creative) only gave one answer and one way of solving the problem. Subjects with creative thinking level 1 (less creative), able to produce two different answers, and able to present data in two ways of presenting data, but only one is correct. Then the subject with level 2 (creative enough), can give one answer correctly and two ways of presenting the data correctly. While the subject with level 3 (creative) thinking can produce two different answers correctly and two ways of presenting data correctly.
THE IMPACT OF THE COVID-19 PANDEMIC ON THE DEVELOPMENT OF GLOBAL AND RUSSIAN E-COMMERCE
Authors: Diana Iskakova , Li Yang , Mongo Providence Alimasi
Published: September 2021

The intensive development of digital technologies and access to the Internet has transformed the principles of organizing economic relations in the sphere of trade in goods and services. E-Commerce has become one of the most dynamically developing areas in the economy of many countries, but unforeseen circumstances, such as the Covid-2019 pandemic, can probably significantly change the situation with the development of the e-Commerce sector, give the necessary impetus to increase Internet activity and turn the e-Commerce sector into a driver of economic growth in Russia.The article demonstrates the changes that have occurred in the dynamics and structure of international online commerce, describes how the customs preferences have changed under the influence of the pandemic. An adjustment of the estimates of the prospects for the development of global and Russian e-commerce is given.
A INFLUÊNCIA DA ESPIRITUALIDADE NA ASSISTÊNCIA DE ENFERMAGEM EM AMBIENTE HOSPITALAR
Authors: Pires Rosirene Alves , Magalhães Maria Helena Lustosa Rios , Silva Leidiany Souza , Figueredo Rogério Carvalho de , Silva Rafael Souza
Published: September 2021

RESUMO A espiritualidade é um novo caminho para se promover uma assistência de qualidade a pacientes internados nas unidades de saúde e está em ascensão, uma vez que, há uma tendência moderna de se unir a ciência com a espiritualidade na busca de melhorar o processo de cura e reabilitação de pacientes. O objetivo do artigo é compreender a influência da espiritualidade na assistência de enfermagem no âmbito hospitalar. Realizou-se uma pesquisa descritiva exploratória, de natureza qualitativa, com base numa revisão narrativa da literatura, onde foram selecionados trabalhos científicos em língua portuguesa publicadas entre o período de 2012 a 2017, de fontes digitais como: LILACS, BDENF, SCIELO, BIREME, PUBMED e Google Acadêmico. Diante à magnitude da dimensão espiritual reconhecida no presente estudo, foi possível evidenciar o conforto, força e o apoio psicológico que a espiritualidade dá a indivíduos que se deparam hospitalizadas. Visto que estes necessitam de cuidados especiais e principalmente um olhar integral por parte dos profissionais que os assistem. Grande parte dos profissionais da saúde que já o aceitam sem reservas, veem a espiritualidade como uma forma coadjuvante, mas muito importante e significativa ao tratamento e busca na recuperação da saúde. Em outras palavras, nunca se deve abandonar as outras formas de tratamento em prol unicamente da espiritualidade. Ainda são necessários estudos semelhantes direcionados à pacientes com diferentes patologias e em fases distintas do adoecimento, procurando também compreender a importância do significado da espiritualidade para familiares, profissionais envolvidos no cuidado e cuidadores. Palavras-chaves: Espiritualidade na Saúde. Espiritualidade e Enfermagem. Espiritualidade Hospitalar.
MOLECULAR NETWORKING-BASED DEREPLICATION OF AMBUIC ACID DERIVATIVES FROM THE MARINE FUNGUS PESTALOTIOPSIS SP. 4A11
Authors: Kellner Luis , Assis Rhenner , Santos Aline , Targanski Sabrina , Siqueira Kátia , Medeiros Livia , Angolini Célio , Silva Felipe , Soares Marcos , Dias Gustavo , Silva Marcio , Cunha Wilson , Pauletti Patricia , Koolen Hector , Januario Ana
Published: September 2021

Ambuic acid (AA) is a highly-modified cyclohexenone and known as a promising inhibitor of quorum sensing in methicillinresistant Staphylococcus aureus, and is thus a candidate as an antivirulence drug. This molecule is mainly produced by the species of Pestalotiopsis and, since its discovery twenty years ago, only a restricted amount of AA-derivatives have been described. Despite being a promising subject, methods for the analysis of modified AA-analogues via mass spectrometry remain unexplored. In order to adress this question, the marine fungus Pestalotiopsis sp. 4A11 associated with the ascidian Didemnum perlucidum was grown in a solid rice medium and its crude extract was chemically studied. From this extract, AA and 10-hydroxy ambuic acid (10-HAA) were isolated and identified using NMR spectroscopy with the aim of obtaining model compounds for the MS analysis. These served as reference compounds (seeds) to guide the dereplication of other AA-analogues via LC-MS/MS-based molecular networking. Based on the manual interpretation of the fragmentation pathways of the seeds and related compounds observed in the networks, six AA-derivatives were dereplicated in the extract. Furthermore, three analogues with unprecedented chemical formulas were proposed as putative unprecedented AA-derivatives. The fragmentation annotation proposed represents a fast and feasible method for characterizing AA-derivatives.
UMA BREVE REVISÃO SOBRE A CATÁLISE POR ÁTOMOS ISOLADOS: CONCEITOS E APLICAÇÕES
Authors: Ferreira Luanne , Ribeiro Ruan , Madriaga Vinicius , Vasconcelos Sancler , Shimabukuro Eric , Rossa Vinicius , Vieira Sara , Passos Fabio , Lima Thiago
Published: September 2021

A BRIEF OVERVIEW ON SINGLE-ATOM CATALYSIS: CONCEPTS AND APPLICATIONS. Catalytic processes became extremely important for the development of our society, especially after the second industrial revolution. Thus, the research for more efficient catalysts is an obstacle to overcome to achieve cheaper processes, higher yields, and selectivity of desired products. In this context, single-atom catalysis emerges as a promising alternative to unite the advantages of traditional homogeneous and heterogeneous catalysis. Catalysis by single-atoms is a bridge that unites in a single catalyst the ease of recovery and reuse (from heterogeneous catalysis) with the high exposure and uniformity of sites (from homogeneous catalysis). Thus, single-atom catalysts (SACs) and single-atom alloys (SAAs) have already found several applications in the literature, such as in hydrogenation, oxidation, conversion of biomass derivatives, electrocatalysis, and photocatalysis. However, it is essential to emphasize that it is still a field that is expanding and relatively new, with several opportunities and many barriers to surpass. In this review, concepts of homogeneous, enzymatic, and heterogeneous catalysis will be addressed, as well as fundamental aspects of single-atom catalysis, preparation methods, characterization, and current challenges.
Pennisetum glaucum (L.) R. Br. vs. Mucuna pruriens (L.) DC.: efeito do cultivo de espécies de plantas não leguminosas e leguminosas sobre a comunidade de fungos micorrízicos nativos de solos arenosos
Authors: Inara Da Silva Araujo  , Tancredo Augusto Feitosa de Souza  , Karla Selene Forstall-Sosa  , Edjane de Oliveira Lucena  , Samuel Inocêncio Alves da Silva  , Djail Santos
Published: September 2021

Plantas pertencentes a distintas famílias botânicas apresentam efeitos diferentes na composição da comunidade de fungos micorrízicos arbusculares (FMAs) nativos. Realizou-se um estudo para determinar a influência de duas espécies de plantas de cobertura – Pennisetum glaucum (L.) R. Br. e Mucuna pruriens (L.) DC. – sobre a composição da comunidade de FMAs nativos de solos arenosos da zona do brejo paraibano. Para tanto, os tratamentos foram dispostos em delineamento em blocos inteiramente casualizados, com dois tratamentos, três blocos e dez repetições. Observaram-se diferenças significativas entre as plantas de cobertura para o número de glomerosporos (t = 5,79, p < 0,05) e o índice de diversidade de Shannon (t = 5,31, p < 0,05). De forma geral, verificou-se que a comunidade micorrízica presente na rizosfera de P. glaucum apresentou índice de diversidade superior em 4,06% quando comparada com a comunidade micorrízica presente em M. pruriens. Por outro lado, encontrou-se maior número de glomerosporos (> 38,28%) no solo rizosférico de M. pruriens quando comparado com P. glaucum. Conclui-se que M. pruriens, pertencente à família Fabaceae, apresentou efeitos positivos nos processos de esporulação, enquanto P. glaucum, Poaceae, promoveu um ambiente mais propício para o desenvolvimento de uma comunidade de FMA mais diversificada.
Beliefs in relation to elderly between Dentistry undergraduates of private university of Parana
Authors: Herbert Rubens Koch-Filho  , Luis Fernando Beiger  , Matheus Augusto Mendes
Published: September 2021

Aging is a sociocultural concept characterized by the opposite to the youth. Generalization and the lack of knowledge about this stage of life can lead to false assessments that tend to oscillate between positive and negative. Objective: a) To characterize the beliefs about aging of Dentistry undergraduates from a private higher education institution; b) to verify if the belief of the undergraduates had about aging may interfere in the choice of future dental care given to older people, and; c) to assess the profile of the respondents by gender, age and graduation period. Material and methods: This cross-sectional descriptive study was conducted with students properly enrolled in the Dentistry course of a private institution, in 2016 (N = 90). The profile of the population was defined by gender, age and graduation period. It was verified the preference and predilection in future working or not working with a certain age group. Also, the beliefs about aging were investigated through a semantic scale. Distributions of absolute and relative frequencies were made. Statistical analysis was given by using SPSS version 20.0. Results: Most respondents were female (78.9%); with a mean age of 23.34 years; enrolled in the 8th period; 51.1% said they had no preference in future work with particular age range; and, there was a predominance of positive view, with tendencies towards neutrality. There were no statistically significant differences between the beliefs toward aging and the variables: gender, age and period. Statistically significant dependencies were found between the beliefs about old age and preference in working or not working in future treat a certain age range of the population. Conclusion: The respondents have a more positive view of old age; no predilection to provide dental care to a certain age group, highlighting a general and humanist profile in relation to chronological age.
Deciduous molar hypomineralization (DMH) – a rare entity and its clinical management approach
Authors: Priyanka Avisa  , Sreekanth Kumar Mallinen  , Rekhalakshmi Kamatham  , Sivakumar Nuvvula
Published: September 2021

An idiopathic qualitative defect of enamel, affecting one or more of the permanent molars with/without permanent incisors is known as Molar Incisor Hypomineralization (MIH). Similar defect on primary second molars is termed as deciduous molar hypomineralization (DMH). Case report and Conclusion: The prevalence rate of MIH and DMH worldwide is between 2.4%-40.2% and 4.9%-9.0% respectively. Clinically, these defects appear as white, yellow or brown spots, and surface is smooth with normal thickness of the enamel. Lack of quality in the enamel causes porosity that fractures easily under mastication, exposing the dentin, and further allows progression of caries. Hence, this condition should be diagnosed as early as possible for providing a preventive management against caries and avoid post eruptive breakdown. In addition, intervention with full coverage restoration is needful in the management of the affected teeth. Preformed metal crowns (PMCs) are recommended as the best full coverage restoration for managing primary molar teeth. The Hall Technique embraces changing concepts of managing, without local anesthesia, caries removal or tooth preparation. Management of teeth with DMH is challenging as it is quite difficult to achieve anesthesia and due to hypersensitivity, the co-operation of the child is questionable.
In vitro evaluation of gutta-percha dissolution ability of different solvents
Authors: Kelly Cristina Santana de Oliveira  , Flávia Sens Fagundes Tomazinho  , Monique Marchiori  , Marilisa Carneiro Leão Gabardo  , Sérgio Herrero Moraes  , Maria Isabel Anastácio Faria
Published: September 2021

The removal of the filling material during the Endodontic retreatment is essential, so a better action of solvents on the gutta-percha is desired. Objective: To evaluate in vitro the gutta-percha dissolution ability of different solvents. Material and methods: Four solvents (xylol, eucalyptol, citrol, and orange oil) were applied on gutta-percha points, which had been later submitted to the weight loss analysis at 2, 5, and 10 minutes. For each solvent, 30 size #60 main cones were used, divided into three groups. Distilled water was used as control group. The statistical test applied was Kruskal-Wallis. Results: No statistically significant difference occurred among the solvents at 2 minutes (p > 0.05); however, during this period, citrol had the best performance. In longer time intervals, the xylol showed differences compared to eucalyptol at 5 minutes and to eucalyptol and citrol at 10 minutes (p < 0.05). The worst results were found for eucalyptol. Conclusion: This xylol was the solvent with improved ability to dissolve the gutta-percha points, with better results at longer time periods.
Comparative analysis of reflection photoelasticity in mandible’s segment with or without base
Authors: Humberto Gennari Filho  , José Vitor Quineli Mazaro  , Marcelo Coelho Goiato  , Karina Helga Leal Turcio  , Andressa Paschoal Amoroso  , Rosse Mary Falcón Antenucci
Published: September 2021

To analyze if axial loads of 50 N and 100 N, applied on an implant of 3.75 X 10 mm (Conexão-Jaú, SP, Brazil) fixed on the central portion of a prototype of the mandible with and without support base, generate isochromatic fringes of different intensity and ways. Material and methods: The sample was a segment of the mandible with 115 mm in length, 30 mm height, and 12 mm in thickness, from a block of #7 rose wax. This matrix was adapted to a modified articulator in such way that its base could or not keep contact with the lower arm of the articulator, simply by modifying the support axis. An implant was put perpendicular to the segment of the mandible’s body and then the photoelastic model obtained. The healing abutment was screwed to the implant to receive loads from 50 N to 100 N, with the model with or without contact of its base with the inferior arm of the articulator. Results: Alterations in the reflections of the colors was observed when the implants had been submitted to loads of 50 N and 100 N with or without supported base. Conclusion: Based on the results, it can be concluded that during the photoelasticity analyses alterations in the color standards occurred depending on the support of the sample and the applied load.
CVDentus bur for epithelial abrasion in the treatment of melanin pigmentation: case report
Authors: Katiane Vieira Menezes Leite  , Patrícia Oliveira de Souza  , Jussania Fonseca da Paz  , Ana Beatriz Franco Fernandes  , Leonardo Fernandes da Cunha  , Gisele Maria Correr
Published: September 2021

The gingival melanin hyperpigmentation (GMH) is resulted from an abnormal deposition of melanin, but it is not a pathology. However, GMH is an esthetic problem for some people. Some alternatives of treatment for this situation exist. The epithelial abrasion has been an interesting alternative because it has a satisfactory esthetic outcome, is a fast procedure, of easy execution, and low cost. Recently, tips adapted in ultrasound (CVDentus) can be an alternative approach. Objective: To report a clinical case of GMH treated by the technique of the epithelial abrasion with association of instrument adapted in ultrasound. Case report: Patient aged 28 years, melanoderm, sought treatment due to esthetic dissatisfaction because of intense dark color in the maxillary gingiva. The GMH removal was proposed through the technique of the epithelial abrasion CVD bur. Conclusion: The technique of epithelial abrasion using CVD bur was effective in removing GMH at one-year follow-up showing to be easy and safe technique.
Prevalence of oropharynx cancer caused by HPV compared with genital cancer
Authors: Rafaela Guimarães Resende  , Fernanda Garcia Krinski  , Allan Fernando Giovanini
Published: September 2021

For a long time, the literature has established that HPV may be associated to pharynx cancer. Objective: To verify the number of publications in three different databases on the prevalence of oral, esophageal, penile, and cervical-vaginal cancer associated with HPV. Material and methods: The publications were verified in Pubmed, Lilacs, and Bireme databases; the keywords “mouth cancer”, “esophageal cancer”, “penile cancer”, and “cervical vaginal cancer” were associated with HPV. Data were tabulated in absolute numbers. Results: In all databases, the number of cervical carcinoma was much larger than that of other cancers. Conclusion: The number of cervical cancer was the most found associated with HPV because of the histological and specific functional conditions of this site.
Epidemiological survey in oral health of the residents of the Teixeira Island, Paraná, Brazil
Authors: Tiago Rodrigues Suizani  , Bruna Leal de Mello  , Luiza Foltran de Azevedo Koch  , Carolina Dea Bruzamolin  , Marilisa Carneiro Leão Gabardo
Published: September 2021

The epidemiological surveys aim to evaluate the distribution and state determinants or events in health in given populations. Objective: To conduct an epidemiological survey on the socioeconomic condition, use of dental services, referred oral morbidity, self-perception, and oral health of inhabitants of the Teixeira Island, Paraná, Brazil. Material and methods: The study followed the statements of the World Health Organization and the Brazilian National Epidemiological Survey (SB Brazil 2010). Questionnaires were applied, and in the clinical examination the following data were collected: dental trauma, edentulism, fluorosis, caries in deciduous teeth (dmft), caries in permanent teeth (DMFT), Community Periodontal Index (CPI) and Loss of Periodontal Insertion Index (LPII). The data were analyzed with Statistical Package for Social Sciences software, version 21.0, and expresses in frequency tables. Results: Of the 108 inhabitants, 90 participated in the study. The socioeconomics conditions unfavorable were: low income and low schooling. The water supplying was not fluoridated. The perception of oral problems was reported by 82.2%; 48.9% declared to have had toothache in last the six months; the reason of search for care was predominantly for curative treatments. Almost 30% of the participants declared to be unsatisfied with their oral health. The values of DMFT and dmtf indexes were 13.9 and 1.2, respectively. The greater demand for maxillary prosthesis occurred in 39.7% of the sample, while 34.2% needed mandibular prosthesis. Conclusion: The oral diseases illnesses and need of treatment were evidenced in the sample, as well as risk factors that deserve attention of the public power.
Maus-tratos na infância e adolescência: percepção e conduta de profissionais de nível superior que atuam na Estratégia Saúde da Família
Authors: Priscilla Lesly Perlas Condori  , Stephanie Camila Lopes do Nascimento  , Aline Both Dubal Mitie  , Eduardo Pizzatto  , Verônica de Azevedo Mazza  , Marilene da Cruz Magalhães Buffon
Published: September 2021

Os maus-tratos infantis são um problema mundial com graves consequências que podem perdurar por toda a vida. Objetivo: Analisar o processo de notificações de maus-tratos contra crianças e adolescentes por profissionais de saúde com nível superior que atuam na Estratégia Saúde da Família (ESF) em dois municípios da região metropolitana de Curitiba/PR. Material e métodos: Trata-se de um estudo observacional, transversal, descritivo, com abordagem quantitativa. Participaram 97 profissionais que atuam na ESF nos municípios de Colombo/PR e Piraquara/PR. Foi utilizado um questionário autoaplicável sobre dados sociodemográficos, formação profissional, conhecimento sobre o tema e notificação de casos de maus-tratos infantojuvenis. Resultados: Observou-se que a maioria dos profissionais conhecia a ficha de notificação (64,9%), sabia conduzir o caso suspeito, optando pela notificação (69,5%), e que se sente capaz de identificar casos de maus-tratos (75,2%). Conclusão: Apesar de grande parte desses profissionais demonstrar conhecimento sobre o tema, é necessário que seja abordado de forma contínua no processo de educação permanente do Sistema Único de Saúde (SUS).
Tratamento de trauma oclusal anterior com pino de fibra de vidro associado à coroa de dissilicato de lítio
Authors: Raisa Carolina Hintz  , Rafaela Caramori Saab  , Eugenio Garcia  , Sergio Paulo Hilgenberg  , Leonardo Fernandes da Cunha  , Tatiana Miranda Deliberador  , Carla Castiglia Gonzaga
Published: September 2021

A aparência estética é uma das preocupações do ser humano, o que leva a uma busca constante por uma estética que expresse harmonia, naturalidade e expressividade. Sendo assim, os procedimentos restauradores têm contribuído positivamente para a resolução dos desafios odontológicos estéticos. Objetivo e relato de caso: Relatar um caso clínico com associação de clareamento dental, confecção de pino intrarradicular e coroa indireta em dissilicato de lítio em que foi devolvida ao paciente a estética desejada. Paciente de 23 anos de idade fraturou o incisivo central superior direito na infância; insatisfeito com a instabilidade de cor do dente, buscou novas alternativas de tratamento. Conclusão: A associação de diferentes tratamentos na Odontologia estética pode apresentar resultados satisfatórios para o restabelecimento estético e funcional de dentes anteriores.
Conhecimento do cirurgião-dentista sobre o manejo e tratamento de fratura radicular horizontal em Curitiba, Brasil
Authors: Jhony Ross Alves Martins  , Alessandra Soares Ditzel  , Aaron Bensaul Trujillo Lopez  , Adriane Antoniw  , Luiza Giacomet Cassol  , Marcos Felipe Iparraguirre Nuñovero  , Thomaz Jefferson de Lemos Pessoa  , Vânia Portela Ditzel Westphalen
Published: September 2021

A fratura radicular ocorre em uma frequência que varia de 2,5 a 8,7% dos traumas dentários. Objetivo: Avaliar o conhecimento do cirurgião-dentista clínico geral da rede municipal de saúde de Curitiba (PR) a respeito de fratura radicular horizontal e comparar os resultados obtidos nesta investigação (grupo 2) com um estudo desenvolvido em 2009 (grupo 1). Material e métodos: Para a realização deste trabalho, um questionário (utilizado no estudo de 2009) sobre conduta e manejo da fratura radicular horizontal foi aplicado aos cirurgiões-dentistas. Os dados foram analisados por meio do teste χ2 e teste Z de diferença entre duas proporções. A amostra foi composta de 81 cirurgiões-dentistas (grupo 2) e 59 cirurgiões-dentistas (grupo 1). Resultados: Houve maior porcentagem de acerto para o grupo 1 quando comparado ao grupo 2, em relação à conduta na fratura radicular horizontal com ou sem deslocamento do terço coronário e quanto ao prognóstico do dente no que tange à posição da fratura. Não houve diferença estatisticamente significante entre grupos a respeito do tecido pulpar, com ou sem deslocamento dos terços. Sobre a permanência da contenção, houve maior acerto entre o grupo 2.
Fratura bilateral de mandíbula atrófica
Authors: Luciana SIGNORINI  , Paula MARINHO  , Cléber Machado de SOUZA  , Antônio Carlos Domingues de SÁ  , Ramon César GONÇALVES
Published: September 2021

O aumento da população de idosos no Brasil trouxe um maior número depacientes nessa faixa etária para o atendimento em diversas áreas daOdontologia. Os pacientes idosos estão expostos a vários tipos de agentesagressores, como quedas e acidentes que geram fraturas maxilofaciais,necessitando então do atendimento especializado do cirurgiãobucomaxilofacial. Os idosos apresentam uma condição diferenciada, comalterações sistêmicas e utilização de vários fármacos, que precisam serlevados em conta no planejamento terapêutico de cada caso. O tratamentodos traumatismos faciais deve objetivar a rápida recuperação do pacientecom a mínima morbidade. Os autores apresentam um caso de fraturabilateral de mandíbula em paciente geriátrico edêntulo, com atrofia severa,tratado com osteossíntese com placa e parafusos de titânio. A recuperaçãodo paciente foi satisfatória, sem complicações pós-operatórias em 18 mesesde controle.
Associação entre a duração do aleitamento materno e sua influência sobre o desenvolvimento de hábitos orais deletérios
Authors: Fabiana Vargas FERREIRA  , Ana Maria MARCHIONATTI  , Marta Dutra Machado OLIVEIRA  , Juliana Rodrigues PRAETZEL
Published: September 2021

Introdução e objetivo: O objetivo deste estudo foi identificar a presença de hábitos bucais deletérios e relacioná-la com a duração de aleitamento materno. Material e métodos: Foi realizado um estudo retrospectivo, utilizando-se dados secundários contidos em 143 prontuários de crianças entre 0 e 59 meses, assistidas em clínica pública de Odontopediatria. Nos prontuários, constavam perguntas sobre a presença de hábitos bucais e sua frequência, bem como o período de duração do aleitamento materno. Os dados foram analisados pelo emprego do teste do qui-quadrado, com nível de significância de 5%. Resultados: Verificou-se a presença de sucção de chupeta em 94 crianças (76,4%), respiração bucal em 28 (22,7%), bruxismo em 18 (14,7%) e sucção digital em 15 (12,2%). Dos 143 prontuários analisados, em 94 (65,7%) a duração relatada do aleitamento materno foi inferior a seis meses. Houve associação estatisticamente significante entre tempo de aleitamento materno e presença de hábito bucal deletério. Conclusão: O tempo insuficiente de aleitamento no peito está associado à presença de hábitos bucais deletérios.
Pyridine/Pyrimidine Substituted Imidazol-5-one Analogs as HIV-1 RT Inhibitors: Design, Synthesis, Docking and Molecular Dynamic Simulation Studies
Authors: Mokale Santosh , Lokwani Deepak , Mujaheed Abdul
Published: September 2021

Background:

This paper reports the synthesis, Non-nucleoside reverse transcriptase inhibitory
(NNRTIs) activity and computational studies of 2-((4-chloro-2-subtitutedphenoxy)
methyl)-4-(furan-2-ylmethylene)-1-substituted Pyridine/-pyrimidine-1H-imidazol-5(4H)-ones.

Methods:

The imidazol-5-one analogs were synthesized by conventional method and characterized
by FT-IR, NMR and mass spectral data. All compounds were evaluated for in-vitro NNRTI activity
by using reverse transcriptase (RT) assay kit (Roche). The in-silico docking studies were conducted
on RT enzyme to investigate binding site interactions of synthesized compounds. The MMGBSA
method was also used to calculate the binding free energy between the inhibitors and RT enzyme.
The MD simulation was further performed for the apo form of the RT enzyme and docked
complex of compound A6-RT enzyme to better understand the stability of the protein-ligand complex.

Results:

The bioactivity analysis revealed that most of the synthesized compounds showed significant
inhibitory activity against RT enzyme and the IC50 value was found to be in the range of
1.76-3.88 μM. The computational studies suggest that the docked compounds form the H-bonding
with amino acid residue Lys101 and hydrophobic interactions with amino acid residues Tyr188,
Tyr181, Trp229, and Tyr318, which act as the primary driving forces for protein-ligand interaction.

Conclusion:

The reported imidazol-5-one analogs can act as lead for further development of
prospective RT inhibitors.
Bridging Oral and Systemic Health in Children with Prader-Willi Syndrome: Case Reports and Dental Treatment Recommendations
Authors: Ritwik Priyanshi , Vu Jaclyn
Published: September 2021

Background:

Prader-Willi Syndrome (PWS) is a complex neurodevelopmental disorder caused by gene alterations on chromosome 15q11-q13, resulting in hyperphagia and neuroendocrine deficits. A comprehensive guide for dental treatment for PWS is lacking despite numerous case reports. The objective of this report was to develop a problem-focused list of the interrelationship between oral and systemic parameters of PWS and enable dentists in anticipating the unique treatment needs of children and individuals with PWS.

Methods:

Four pediatric patients with PWS presenting to an academic dental clinic were evaluated. A literature review spanning the last twenty years was performed to identify the pathophysiological impact of systemic problems on dental health and treatment.

Results:

The four cases along with cases from the literature were used to enumerate salient oro-dental and systemic features influencing treatment decisions in dentistry. They formed the basis for collective recommendations and precautions for rendering dental treatment in patients with PWS.

Conclusion:

Sedation for dental treatment is contraindicated due to obesity (BMI over 95th percentile), hypotonia, obstructive sleep apnea (OSA), and respiratory limitations (restricted ventilation due to weight on thoracic cage). Prolonged recovery from general anesthesia, OSA, and temperature dysregulation necessitate extended monitoring after dental rehabilitation under general anesthesia. Orthopedic problems and respiratory limitations exclude protective stabilization. Xerostomia and acidic saliva necessitate recommendations for oral rehydrating products. Periodontal assessment is necessary due to poor oral hygiene and diabetes mellitus. Early establishment of a dental home and risk-based frequency of dental care should address caries prevention and restorative needs.
A Review of Diagnostic Reference Levels in Computed Tomography
Authors: Ozsahin Ilker , Dawd Jemal Edris , Ozsahin Dilber Uzun
Published: September 2021

:

Computed Tomography (CT) scanning generates 3-D images of the inside structures of
the body by delivering a comparative radiation dose to the patient. This requires great concern of
optimization via establishing Diagnostic Reference Level (DRL). DRL values can be estimated
based on reference patient percentiles (such as 90th, 75th, and 50th) dose distribution. DRL has significant
uses in professional judgments by generating harmonized evidence about the radiation dose
received by the patient. The primary goal of this review is to assess the practical application of
DRL in CT procedures internationally. The main objective of establishing DRLs is to optimize the
patient dose without compromising the image quality in order to obtain adequate diagnostic information.
That means the inescapability of DRL for a country in medical diagnosis is to reduce the
limitation of dose dispersion, to harmonize and expand the good practice, to narrow large dispersion
of doses, and to create systematic supervision for unwanted radiological doses. The review presents
that international records have a wide range of mean dose distributions due to the variation of
exam protocols and technical parameters in use. Hence, this review recommends that each CT
health facility are required to exercise careful dose reduction strategies by accounting for adequate
image quality with sufficient diagnostic information via follow-up of concerned bodies.
Microcytic Anaemia as Susceptibility Factors in Bipolar Spectrum Disorders: Review of the Literature, Replication Survey, and Co-Segregation within Families
Authors: Bocchetta Alberto , Chillotti Caterina , Ardau Raffaella , Sollaino Maria Carla
Published: September 2021

Background:

Potential interactions between mood disorders and microcytic anaemias have been suggested by case reports, surveys of haematological parameters in psychiatric populations, and surveys of psychiatric morbidity in thalassaemic carriers.

Objectives:

a) To review published studies.

b) To study the prevalence of microcytic anaemia in a sample of Sardinian outpatients with recurrent mood disorders.

c) To check whether mood disorders and microcytic anaemia co-segregate within families.

Methods:

We extracted data on blood count and serum iron concentrations from the records of patients admitted between January 1st, 2001 and December 31st, 2016, to our clinic for mood disorders. Moreover, we studied siblings of subjects with both major mood disorders (according to Research Diagnostic Criteria) and heterozygous thalassaemia (according to Mean Corpuscular Volume, serum iron, and haemoglobin A2 concentrations). Siblings affected with a major mood disorder were examined for haematological concordance with the proband (reduced MCV and/or increased HbA2 in case of heterozygous β-thalassaemia, or presence of gene deletions in case of α-thalassaemia).

Results:

Microcytic anaemia was highly prevalent (81/337 = 24.0%) among outpatients with mood disorders. Starting from 30 probands with heterozygous ß-thalassaemia, concordance for reduced MCV and/or increased HbA2 was found in 78% (35/45) of affected siblings. Starting from 3 probands with heterozygous α-thalassaemia, only one of the 5 affected siblings carried four α-globin functional genes.

Conclusion:

Based on the review of the literature, the high prevalence of microcytic anaemia in outpatients, and the concordance between affected siblings, we can conclude that a role of heterozygous thalassaemias is highly probable. Future studies are required to establish the relevance of heterozygous thalassaemias and evaluate the magnitude of the effect, possibly using a molecular diagnosis also in the case of heterozygous β-thalassaemia.
Factors Influencing Younger Users’ Continued Adoption of e-Health: A Study on Hospital Public Platform in a Large Public Hospital in China (Preprint)
Authors: Yuan Ruan , Qian Xie , Caibo Wu
Published: September 2021

BACKGROUND

With the rapid development of the internet, hospital public platform (HPP) has been designed for the use in top state-owned public hospitals since 2009 to provide patients with appointment registrations, test result inquiry, online payment, online consultation and other services. This study was conducted to measure continued adoption and to identify factors that influence patients’ continued adoption of HPP.

OBJECTIVE

This study was conducted to measure continued adoption and to identify factors that influence patients’ continued adoption of HPP.

METHODS

Expectancy Confirmation Theory (ECM-ISC) and Theory of Planned Behavior (TPB) was used to assess the users’ continued adoption of HPP. A questionnaire was distributed to patients in Beijing Friendship Hospital, which measured constructs, including perceived usefulness, expectation confirmation, satisfaction, continuance intention, subject norm, perceived behavior control and adoption behavior. Structural equation modeling (SEM) was performed to test the theoretical model.

RESULTS

The expectation confirmation significantly affected perceived usefulness, and satisfaction significantly affected continuance intention, while perceived usefulness had no significant effect on satisfaction and continuance intention. The subjective norm and perceived behavior control had significant influence on continuance intention. Perceived trust significantly affected satisfaction and continuance intention. The expectation confirmation had no significant impact on satisfaction, but it could affect satisfaction indirectly through perceived trust. Habit had a significant influence on adoption behavior and had a significant moderate effect between continuance intention and adoption behavior.

CONCLUSIONS

The findings of this study provide an applied guideline for the successful application of e-health systems in public hospitals in cities. It also creates an opportunity for e-health service providers to have a better understanding of their patients, which may have far-reaching and positive implications for China’s ongoing reforms.
What Twitter Can Tell Us About User Experiences of Crisis Text Lines: A Qualitative Study (Preprint)
Authors: Coady Alanna , Lainchbury Keeley , Godard Rebecca , Holtzman Susan
Published: September 2021

BACKGROUND

Mental health problems are the leading cause of disability worldwide. Despite the prevalence and cost of mental illness, there are insufficient health services to meet this demand. Crisis hotlines have a number of advantages for addressing mental health challenges and reducing barriers to support. Further, mental health crisis services have recently expanded beyond telephone hotlines to include other communication modalities such as crisis chat and text messaging services, largely in response to the increased use of mobile phones and text messaging for social communication.

OBJECTIVE

Despite the high uptake of crisis text line services (CTLs) and rising mental health problems worldwide, CTLs remain understudied. Thus the current study aimed to address an urgent need to evaluate user experiences with text-based crisis services.

METHODS

The current study explored user experiences of CTLs by accessing users’ publicly available Twitter posts that describe personal use and experience with CTLs. Data were qualitatively analysed using inductive thematic analysis.

RESULTS

Six main themes were identified from 776 tweets: (1) approval of CTLs, (2) helpful counselling, (3) invalidating or unhelpful counselling, (4) problems with how the service is delivered, (5) features of the service that facilitate accessibility, and (6) indication that the service suits multiple needs.

CONCLUSIONS

Overall, there was strong evidence to support the value of text-based crisis support, as many users reported positive experiences of effective counselling that provided helpful coping skills, de-escalation, and reduction of harm. Results also identified areas in need of improvement, particularly ensuring more timely service delivery and effective communication of empathy and support. Text-based services may require targeted training to apply methods that effectively convey empathy in this medium. Moving forward, CTL services will require systematic attention in the clinical research literature to ensure their continued success and popularity among users.
Colonialism and Its Effect on African Conflict
Authors: Achudume PhD Tobi
Published: September 2021

Colonialism is a major part of Africa’s history and therefore plays a major role in the types of conflict present in the continent. While in the international community, there seems to be more inter-state and economic conflicts, African conflicts are characterised by internal differences, hence intra-state conflicts. Though there were five major colonial powers present in Africa, this study explores the two major ones- Anglophone and Francophone. Both forms of colonialism share some similarities which are explored in this paper. As with the different policies practiced by both France and Britain, there are differences in the form of colonialism and how it was administered. These differences are explored in this paper. Finally, this paper analyses the effect of colonialism on the type of conflict most common in Africa. This paper answers the question of post-colonial experiences in Africa and its effects on the types of conflict present in the continent.
Can Tumbling without Brine Improve Tenderness and Proteolysis of Beef Loin Muscles?
Authors: Tuell Jacob R. , Qianqian Yu , Kim Brad
Published: September 2021

Tumbling of intact muscle foods has been widely applied toprocessed meats using brine solution. However, the use of tumbling withoutbrine on fresh beef muscles has not been fully examined. Therefore, this studyaimed to evaluate fresh beef tumbling on meat quality and proteolytic featuresof loin (longissimus lumborum)muscles. Moreover, interactions with the duration of postmortem aging wereinvestigated. Loins (n=9) at 7d postmortem were sectioned and allocated among twotumbling (T) treatment groups at 60 (T60) or 90 (T90) minutes, as well as a non-tumbledcontrol (T0) group. After treatment, sub-sections were made and divided among0d, 7d, or 14d of further aging. Meat quality was assessed by shear forcevalues, water-holding ability, and color attributes. The extent of proteolysiswas determined by quantification of desmin and troponin-T, myofibrilfragmentation index (MFI), and transmission electron microscopy. An interactionbetween fresh beef tumbling and aging duration was observed in shear forcevalues (P=0.032). At 0d, muscles fromT90 exhibited lower shear force (21.6 N) compared to T0 (34.8 N) and T60 (24.7N) groups. Muscles from T60 and T90 groups maintained lower shear force than T0controls at each respective aging duration.Higher cooking loss (P=0.011) but notpurge loss (P=0.412) was observed in theT60 and T90 groups compared to T0. Shear force results were supported by higherMFI in T60 and T90 groups than T0 controls (P<0.001), as well as the disappearance of intact troponin-T withfurther aging (P=0.009). Transmissionelectron microscopy supported increased initial tenderness would owe primarily tophysical disruptions to myofibrillar structure, though fresh beef tumbling may facilitateproteolysis with further aging.
Быстродействующие болометрические матричные детекторы
Authors: Хафизов Р.З. , Старцев В.В. , Москвичев В.Ю.
Published: September 2021

В статье представлены результаты исследования возможностей уменьшения времени отклика (постоянной времени тепловой релаксации) на тепловое воздействие болометрического сенсора. Анализ проведен в рамках общепринятой теории поглощения ИК-излучения и теплофизических процессов, протекающих в мембранных МЭМС-структурах. Представлены результаты аналитических оценок, оптимизирующие конструкцию микроболометрического элемента матричного детектора для улучшения его характеристик быстродействия с учетом требований конкретных применений. Выявленные закономерности будут применены в производстве микроболометров семейства «Астрон».
Перестраиваемый одночастотный полупроводниковый лазерный модуль на базе двухпроходного усилителя на длину волны 1 550 нм
Authors: Дураев В.П. , Вороненко С.А. , Молодцов И.С.
Published: September 2021

Представлены результаты работ по созданию перестраиваемых одночастотных полупроводниковых лазерных модулей на длину волны 1550 нм с внешним резонатором на основе волоконных брэгговских решеток (ВБР), сформированных в одномодовом волоконном. Рассмотрены способы дискретной и плавной перестройки длины волны излучения. Представленные лазерные модули способны генерировать динамически стабильное одночастотное излучение с подавлением боковой моды более 40 дБ, шириной линии генерации 100–500 кГц и выходной оптической мощностью более 35 мВт. Перестройка длины волны спектра излучения лазерного модуля составила 1,5 нм.
Backlash contra o sistema interamericano de direitos humanos. Uma análise sobre o caso Venezuela
Authors: Oliveira Magalhães da Silva Loureiro Claudia Regina de
Published: September 2021

O objetivo do artigo é analisar o movimento de ataque às instituições internacionais a partir do caso da Venezuela na visão da teoria denominada backlash e os prejuízos à cláusula democrática no sistema interamericano de direitos humanos. O trabalho abordará a situação da Venezuela perante o ordenamento jurídico doméstico e diante dos sistemas internacionais de proteção aos direitos humanos para contextualizar os efeitos do backlash no sistema interamericano, bem como as consequências da denúncia dos tratados internacionais e a retirada da Organização Internacional para a cláusula democrática e para a prevalência dos direitos humanos. O desenvolvimento do trabalho seguirá o método dedutivo, com a análise jurisprudencial e doutrinária relativa ao tema, no sentido de afirmar que não pode um Estado exonerar-se do dever de cumprir com os direitos humanos em razão da universalidade desses direitos, do direito transnacional e da globalização.
Estándares convencionales en procedimientos de personas migrantes
Authors: Beltrán Orjuela Natalia , Palacios Segura Leydi Marcela
Published: September 2021

El artículo aborda el estudio del control de convencionalidad directo realizado por la Corte Interamericana de Derechos Humanos, en relación con los derechos humanos a las garantías judiciales y protección judicial de las personas en calidad de migrantes. El resultado se obtiene a partir de una investigación básica jurídica, descriptiva y deductiva, que permite identificar los espacios convencionales generados a partir de espacios citacionales, los cuales se desarrollan en la función consultiva y contenciosa de la Corte Interamericana de Derechos Humanos.
Impact of Privatization on Airlines
Authors: Shah Vidhi
Published: September 2021

Abstract: The purpose of this paper is to study and identify the factors such Boarding and clearance time, Ease of E-ticketing and luggage capacity and their effect on Customer Preference in the airline. This study examines the underlying forces of service quality influences on passenger’s satisfaction in aircraft transport. The study examines which dimensions have a positive influence on service quality and which dimensions have the most and least important impact on service quality in international air travel, as perceived by airline passengers, thereby ultimately targeting maximum monetary benefits. It is a qualitative research based on subjective examination of behavior, attitude & impressions. The simplification of research support is mainly based on group discussion of respondents. The data was collected through a Focused Group Discussion. Two FGD’s each consisting of 10 participants were recorded. The findings show that how the customers preferred one airline to others because of its quality, pricing and technology and frequency of flights. The participants talked much in depth about the quality and the treatment by staff inside the airplane. They also mentioned the details about the slowdown and fallout of the airline sector in India. The limitations are that it is constraint only to Mumbai. The participants lacked knowledge of the working of the airline industry as they did not travel frequently through airplanes. Keywords: Quality, Preference, Technology, Pricing, and Punctuality
Consumer Perception’s Towards Organic Products in Bangalore City
Authors: Sheshadri Dr. Y.V.
Published: September 2021

Abstract: A natural product is made from materials produced by using natural agriculture. There are one-of-a-kind types of natural merchandise. However natural product is more acknowledged for food gadgets like organic grocery, natural vegetables, and natural certified meals and so on. The study focuses on the consumer perceptions regarding organic product and the changing trend of the consumers towards organic products. Conveyance sampling technique is used to collect the data and the data is analysed by using chi square and ANOVA. Key words: Organic products, perception, environment and forming.
Texto de Silvia Soler. Los trapitos al sol.
Authors: Soler Silvia
Published: September 2021

Un profesor de historia me dijo una vez que la ropa tendida era uno de los temas más portentosos de la literatura moderna. No sé de dónde sacó la frase, ni le exigí argumentos que la avalaran porque en ese entonces yo escuchaba sus palabras con devoción, y lo tomé por cierto.