bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-Term Monitoring of Liver Fibrosis and Steatosis in Patients with Chronic Hepatitis C after Achieving a Sustained Virologic Response to Antiviral Therapy
Authors: Dudina K. R. , Belyy P. A. , Maev I. V. , Safiullina N. Kh. , Klimova E. A. , Shutko S. A. , Znoyko O. O. , Yushchuk N.  D.
Published: March 2023

Aim: to analyze the dynamics of fibrosis and steatosis of the liver according to fibroelastometry in patients with chronic hep-atitis C (CHC) after ≥ 6 months from transient elastometry (TE) achieving a sustained virologic response (SVR) to antiviral therapy.

Materials and methods. At baseline, a prospective observational study included 628 CHC patients with known stage of liver fibrosis (F) before AVT, some of whom were phased out due to non-compliance with the inclusion criteria. The final analysis included 297 patients who had transient elastometry (TE) data with CAP™ technology on the severity of liver fibrosis (± steatosis) before treatment and after ≥ 6 months after reaching SVR (67 % – interferonfree regimens of therapy). Median follow-up from the moment SVR was confirmed was 3 years [2; 6].

Results. At the end of the study, the average age of patients was 49 ± 12 years, of which 53 % were men. In the long-term period after reaching SVR, regression of liver fibrosis was diagnosed in 80 % of cases (including in patients with cirrhosis), and the progression of fibrosis was in 3 % of patient. At the same time, regression of liver steatosis was detected only in 31 % of the patient, worsening of the results was in 23 % (26 % of them had the appearance of steatosis (S) of the liver of 1–3 degrees in persons with no fatty liver before the start of AVT). In the group of patients with liver steatosis, the proportion of men was significantly higher (p = 0.004). Clinically significant stages of fibrosis F3–F4 were significantly more often recorded in patients with hepatic steatosis, both before treatment (46 % S1–S3 and 22 % S0, p < 0.001) and after ≥ 6 months after reaching SVR (19 % S1–S3 and 9 % S0, p = 0.023).

Conclusion. In patients with chronic hepatitis C with SVR achieved in the long term, despite a significant regression of liver fibrosis, a high prevalence of hepatic steatosis remains. The data obtained indicate the feasibility of routine diagnosis of both fibrosis and steatosis of the liver in the management of patients with chronic HCV infection before and after successful antiviral therapy.
Prognostic Models of Primary Sclerosing Cholangitis
Authors: Dolgushina A. I. , Selyanina A. A. , Dubrovina V. V. , Isyangildina G. A. , Olevskaya E. R.
Published: March 2023

Aim:to study the significance of prognostic scales in a target group of patients with primary sclerosing cholangitis (PSC) living in the Chelyabinsk region.

Materials and methods.The study included 21 patients with a confirmed diagnosis of primary sclerosing cholangitis (PSC) and a disease duration of at least two years. The primary endpoint studied was death. The MELD, Mayo Risk Score, Amsterdam-Oxford PSC Score, PREsTo score, and UK-PSC Score scales were calculated based on the medical records. Statistical processing was carried out using the SPSS Statistics v.22 application.

Results.A retrospective assessment of the risk of mortality using the MELD, Mayo Risk Score and Amsterdam-

Oxford PSC Score did not reveal a statistically significant difference between deceased and surviving patients. The UK-PSC Score scale showed the highest predictive value (p= 0.046).

Conclusion.The new predictive model UK-PSC Score showed advantages in predicting death in PSC patients compared to other scales.
Management of a Female Patient with Irritable Bowel Syndrome and Somatoform Disorder
Authors: Trush E. A. , Poluektova E. A. , Beniashvili A. G. , Shifrin O. S.
Published: March 2023

Aim: to demonstrate the management of a patient with somatization disorder and irritable bowel syndrome.

Key points. A 41-yo female patient was admitted with complains of spastic lower abdomen pain, hard stool once every 1–2 days under laxative treatment (macrogol), bloating, anxiety, waiting for confirmation of a life threatening illness, internal stress, difficulty in falling asleep, shallow sleep. Has a long history of disease, characterized by the appearance of a variety of somatic symptoms (headache, tachycardia, joint pain, stool disorders, abdominal pain, etc.) during periods of emotional tension, lack of data suggesting organic disease. No abnormal changes were detected in examination at the clinic (complete blood count, serum chemistry tests, urinalysis or fecal tests, hydrogen and methane breath tests with lactulose, abdominal ultrasound, esophagogastroduodenoscopy, colonoscopy). With the prior agreement of patient, she was consulted by a psychiatrist and diagnosed with somatization disorder and mild anxiety disorder. On discharge from hospital recommended cognitive-behavioral therapy, continue taking macrogol, as well as treatment with Kolofort. After 3 months of complex treatment, there was a significant decrease in the severity of both the symptoms of irritable bowel syndrome and anxiety disorder.

Conclusion. For patients whose complaints meet the diagnostic criteria for IBS, a two-stage differential diagnosis may be justified: at the first stage, differentiation of IBS and organic diseases of the gastrointestinal tract is carried out; at the second stage - IBS and somatization disorder. Kolofort can be the drug of choice both in patients with IBS and the pharmacological part of therapy in patients with somatization disorder.
Clasificación socio-agronómica de fincas productoras de plátano en la región Caribe de Costa Rica
Authors: Mora Calvo Vesalio , Rojas Sanabria Patricio , Chaves Méndez Nancy
Published: March 2023

RESUMEN. Introducción: El plátano es un alimento para millones de personas en países en desarrollo, y en Costa Rica la producción se localiza principalmente en la región Caribe, con 3 354 fincas de baja productividad y poca adopción tecnológica. A pesar de ser un cultivo presente en el 55,8% de las fincas pequeñas en la provincia de Limón, son escasos los estudios sobre condiciones de fincas y las personas que cultivan plátano. Objetivo: Elaborar una tipología de las fincas productoras de plátano de la región Caribe de Costa Rica según productividad Métodos: Se realizaron 342 encuestas a finqueros en seis cantones, que corresponden al 28% de las fincas plataneras afectadas por la inundación del 2015. Resultados: Se clasificaron tres tipos de fincas, la tipo 1 son las más eficientes en el uso de insumos, en rentabilidad y en productividad con 49 TM/ha/año, pero solo representan el 10% del total de fincas. Estas fincas tienen 0,8 ha de cultivo de plátano, con densidades de siembra mayores a 2 000plantas/ha, usan cormos de 500 a 800g, aplican sulfato de amonio, apuntalan las plantas, embolsan los racimos, renuevan las plantaciones cada 1 a 2 años y las personas que atienden estas plantaciones son menores de 50 años. Por otro lado, el 66% de las fincas productoras se ubican en el tipo 3 cuya producción es de 18TM/ha/año. Conclusión: Las fincas de los seis cantones presentan significativas diferencias, en especial en área cultivada y productividad, siendo las fincas menores a 1ha los más eficientes y de mayor rentabilidad, y las de Alta Talamanca las más biodiversas con el 79% de las fincas manejadas como Sistemas agroforestales. El cultivo del plátano es un sistema de producción vulnerable, principalmente por el manejo agronómico, los escasos controles fitosanitarios y la débil capacitación que reciben las personas agricultoras.
Treatment of Partial-Thickness Burn Wounds with Combined Advanced Therapies: Cultured Allogenic Keratinocyte and Epidermal Growth Factor
Authors: Lee Key Day , Cha Eun Choang , Lee Jimin , Kang Sang Yoon , Burm Jin Sik , Cho Jaeyoung
Published: March 2023

Background: Cultured allogenic keratinocyte (CAK) and epidermal growth factor (EGF) are commonly used biological treatments for partial-thickness burn wounds. A comparative study was conducted on whether the combination therapy of CAK and EGF promotes partial-thickness burn wound healing.Methods: From January 2020 to March 2021, 73 patients who visited the hospital with partial-thickness burns were enrolled in the study. Patients were treated with CAK (Kaloderm) (n=20), EGF (Easyef) (n=17), and CAK+EGF (n=24). Wound healing rate, time to heal, factors affecting wound healing (age, sex, underlying disease, mode of injury, location of injury, initial wound size), and scarring were comparatively analyzed.Results: The wound healing rate for 20 days was 85% (17/20) in the CAK group, 88% (15/17) in the EGF group, and 92% (22/24) in the CAK+EGF group. The average healing time was 11.0±6.0 days, with the CAK group taking 12.6±5.5 days, EGF group taking 11.5±6.0 days, and CAK+EGF group taking 9.0±6.3 days. The patients who received CAK+EGF treatment had higher hazard than the patients without CAK+EGF treatment (hazard ratio, 2.078; 95% confidence interval, 1.021–4.228). Smaller wound size <5 cm2 (hazard ratio, 2.869; 95% confidence interval, 1.426–5.773) was associated with complete wound healing. Though statistically insignificant (P=0.218), less scars occurred in the CAK+EGF group.Conclusion: Combination therapy of CAK and EGF promotes wound healing in partial-thickness burn wounds.
Reconstruction of Upper Extremity Using Pedicled Latissimus Dorsi Myocutaneous Island Flap and Skin Graft after Necrotizing Fasciitis: A Case Report
Authors: Na Youngsu , Shin Donghyeok , Choi Hyungon , Kim Jeenam , Lee Myungchul
Published: March 2023

Necrotizing fasciitis of the upper extremities is a severe, life-threatening condition, potentially resulting in amputation or death in the absence of prompt and aggressive surgical treatment. Reconstruction is eventually required after adequate surgical debridement, and patients are often referred to a plastic surgeon for this purpose. Herein, we present the case of a patient with extensive soft tissue defects on the upper extremity after fasciotomy for necrotizing fasciitis. We successfully performed a pedicled latissimus dorsi myocutaneous island flap, full-thickness skin graft, and split-thickness skin graft for this patient. After 2 months, the patient did not have any wound problems and could carry out adequate upper extremity motion.
The Effect of Topical Normobaric Oxygen Therapy on Composite Graft Survival in Fingertip Amputation
Authors: Lee Key Day , Cha Eun Choang , Lee Jimin , Yoon Sihyun , Choi Youngwoong , Cho Jaeyoung
Published: March 2023

Background: Though composite grafting is an easy, simple treatment for fingertip amputation, it is known to have a low survival rate. To increase the likelihood of composite graft survival, various adjuvant therapies such as hyperbaric oxygen therapy, ice-cooling, or vasodilator agents have been used. In this study, we attempted to validate the hypothesis that topical normobaric oxygen therapy (tNBO) could improve composite graft survival in fingertip amputation.Methods: Patients who sustained fingertip amputations and who were treated with composite grafting between January 2015 and July 2020 were included. The patients (n=154) were divided into two groups: those who received tNBO (n=102) and those who had not (n=52). The effect of tNBO on graft survival, survival rate by level of amputation, and risk factors of graft survival (age, smoking, time to surgery, diabetes mellitus, and crush-avulsion injury type) were examined.Results: tNBO significantly increased composite graft survival (75.3% vs. 50%, P<0.001) in amputations distal to the nail base area. Among risk factors, time to surgery >5 hours (odds ratio, 48.6; P=0.001) and crush-avulsion injury type (odds ratio, 10.1; P<0.001) significantly decreased graft survival in both groups. Smoking decreased graft survival only in the non-tNBO group (odds ratio, 28; P=0.015), not in the tNBO-treated group.Conclusion: tNBO increased composite graft survival in fingertip amputation distal to the nail base area. It can be helpful for composite graft survival in smokers.
Complete Bony Segment Flap Failure without Skin Paddle Compromise in Fibular Free Flap: A Case Report of a Rare Early Complication
Authors: Singh Hardeep , Jain Ankit , Jain Rahul , Mahendru Sanjay , Khazanchi Rakesh Kumar
Published: March 2023

The free fibula flap is sometimes associated with partial flap loss. A 62-year-old man with squamous carcinoma of the lower alveolus underwent anterior arch resection and reconstruction with a fibula osteocutaneous flap containing three bony segments. There were two perforators in the skin flap; the first perforator was proximal to the bony segments and the other perforator was at the level of the middle segment. Atherosclerosis was observed in the anastomotic vessels. During surgery, thrombosis occurred in the arterial anastomosis, but was revised before the operation was over. The patient’s early postoperative course was uneventful. In the second week, purulent discharge was observed from the drains. Flap exploration showed devascularization of bony segments and periosteum, but the skin paddle was viable. The peroneal vessel had thrombosed distal to the takeoff of the proximal perforator and the viable skin paddle perfused by proximal perforators falsely indicated the well-being of underlying bones. The de-vascularized bones and sloughed periosteum were removed at the time of exploration, after which the skin paddle was reoriented for coverage of the defect. The patient completed chemoradiation without any bony reconstruction afterwards. This is the only reported case of early total bony flap portion loss with a viable skin paddle in free fibula flap transfer.
Influence of Drain Characteristics and Other Known Risk Factors on Surgical Site Infection Occurrence in Plastic Surgery Patients
Authors: Lee Hye Mi , Park Jin Woo , Na Young Cheon
Published: March 2023

Background: Drains are hypothesized to cause surgical site infections (SSIs). However, research is scarce on how to reduce SSIs after drain placement. We analyzed the association between specific drain characteristics and the occurrence of SSI. We also evaluated the effects of other known risk factors in patients undergoing plastic surgery to reduce SSIs.Methods: We retrospectively reviewed the medical charts of 531 patients who underwent plastic surgery with drain placement between January 2017 and January 2022. Data were analyzed using the chi-square test or Fisher exact test for categorical variables and the Mann-Whitney U test or t-test for numerical variables.Results: SSI incidence was higher in closed drains (15.4%) than in open drains (8.0%). SSIs also occurred more often after delayed drain removal. For open drains, early removal did not decrease SSI incidence. For closed drains, SSI incidence was markedly high when the drain was removed after 6 days. Furthermore, bacterial culture results tended to differ before and after SSI occurrence more frequently in the open drain group. Among the known risk factors for SSIs, smoking, albumin concentration, and wound status were confirmed as significant.Conclusion: Drain removal time was a significant risk factor for SSIs. With open drains, it is important to assess whether SSI occurs at the beginning of drain placement. A higher probability of retrograde infection was confirmed with open drains. Closed drains should be removed within 6 days after placement. Furthermore, smoking, albumin concentration, and wound status should be considered to reduce the incidence of SSIs.
Therapeutic effect of glucose monohydrate on nicotine sulfate- induced toxicity and teratogenicity in Xenopus embryos: an experimental study
Authors: Pekmezekmek Ayper Boga , EMRE Mustafa , TUNC Erdal , SERTDEMIR Yasar
Published: March 2023

Although there is evidence that low doses of nicotine can affect glucose
metabolism, questioning whether glucose can reduce the harmful effects
of nicotine on embryo development may constitute an interesting research
area. This study planned to investigate how concomitant administration
of Glucose monohydrate modulates the effects of exposure to Nicotine
sulfate on embryos of Xenopus leavis by using a 96-h FETAX test. To this
purpose, in-vitro fertilized embryos were treated with nicotine and
glucose, alone or in combination, and then examined in order to
determine likely teratogenic consequences of those treatments. At the
end of FETAX procedure, the ratios of normal, abnormal and dead embyos
were determined and length of embryos were measured in all treatment
groups. Nicotine alone treatment significantly increased the ratios of
abnormal and dead embryos compared to controls. Concomitant treatment of
glucose and nicotine slightly decreased the ratio of abnormals but
increased the ratio of normal embryos in comparison with the results of
nicotine alone treatment group. According to our results, the addition
of Glucose to nicotine showed a protective effect on embryos embryos in
concomitant treatment groups. Confirmation of these results needs
similarly designed, more advanced studies.
Primary prevention of cardiotoxicity in paediatric cancer patients receiving anthracyclines: systematic review and meta-analysis of efficacy and safety profiles
Authors: Li Jiaqi , Lee Ainsley Ryan Yan Bin , Chen Ching Kit , Koo Chieh-Yang , Lee Matilda Xinwei , Sia Ching-Hui
Published: March 2023

Aims: This review aims to evaluate prospective controlled
trials of primary prevention of anthracycline cardiotoxicity in
paediatric cancer patients. Methods and Results: Prospective
controlled trials in which any cardioprotective agent was compared to no
additional therapy or placebo in paediatric cancer patients receiving
anthracyclines (PROSPERO: CRD42022367791). Outcomes were assessed using
random and fixed-effects meta-analysis models as well as a synthesis
without meta-analysis approach. A total of 24 reports of 19 trials were
included in our review, 11 trials administered dexrazoxane, two trials
administered the angiotensin converting enzyme inhibitor enalapril, one
trial administered the beta-blocker carvedilol, one omega-3 fatty acids,
one coenzyme Q10, one amifostine, one silymarin and one black seed oil.
A total of 1333 paediatric patients receiving anthracyclines were
included in meta-analysis of the cardio-protective effect of dexrazoxane
in reducing the risk of developing significant systolic dysfunction. A
risk ratio of 0.44 (95% CI: 0.33 to 0.61; I2 = 0%) was found, showing
that the administration of dexrazoxane was highly effective. Overall,
enalapril, carvedilol and dexrazoxane resulted in less left ventricular
dysfunction and fewer cardiac biomarker abnormalities compared to
placebo. Omega-3 fatty acids, silymarin and black seed oil each
demonstrated benefit through less reduction of systolic function and
fewer cardiac biomarker abnormalities. Conclusion: Enalapril
and dexrazoxane are highly effective in preventing the
anthracycline-induced cardiotoxicity in paediatric cancer patients with
a highly acceptable safety profile. More randomised-controlled trials
are required to reach a conclusion on the efficacy of omega-3 fatty
acids, co-enzyme Q10 and amifostine.
Content-only attention network for social recommendation
Authors: Wu Bin , Zhang Tao , Chen Yeh-Cheng
Published: March 2023

With the rapid growth of social Internet technology, social recommender has emerged as a major research hotspot in the recommendation systems. However, traditional graph neural networks does not consider the impact of noise generated by long-distance social relations on recommendation performance. In this work, a content-only multi-relational attention network (CMAN) is proposed for social recommendation. The proposed model owns the following advantages: (i) the comprehensive trust based on the historical interaction records of users and items are integrated into the recursive social dynamic modeling to obtain the comprehensive trust of different users; (ii) social trust information is captured based on the attention network mechanism, so as to solve the problem of weight distribution in the same level domain; (iii) two levels of attention mechanisms are merged into a unified framework to enhance each other. Experiments conducted on two representative datasets demonstrate that the proposed algorithm outperforms previous methods substantially.
Confining pressure effect on the permeability and mechanical behavior of sandstone under a certain pore water pressure condition
Authors: Ling Wei-Qiang , Xie He-Ping , Li Yi-Hang , Zhang Ze-Tian , Ren Li
Published: March 2023

In geotechnical engineering, the mechanical behavior of rocks under various
In-situ conditions (stress state including axial stress, confining pressure,
pore water pressure) have always been an important topic. Therefore, the
confining pressure effect on the permeability and mechanical behavior of
different size sandstone samples under a certain pore water pressure
condition was studied. The permeability of different sizes samples shows
roughly the same exponential de-creasing law with the increase of confining
pressure. In the mechanical behavior test, both the loading Young?s modulus
E+ and the unloading Young?s modulus E- increased continuously with
increasing confining pressure, while the unloading Poisson's ratio m -
decreased to a certain value and then remained almost constant.
TRADISI NGEJALANG DI PEKON PENGGAWA V TENGAH KECAMATAN KARYA PENGGAWA KABUPATEN PESISIR BARAT
Authors: Marshelia Hakim Ratu
Published: March 2023

Ngejalang merupakan tradisi yang dilakukan secara turun temurun oleh masyarakat Lampung Saibatin di Kabupaten Pesisir barat pada saat lebaran Idul Fitri. Tradisi ngejalang juga diikuti oleh masyarakat Lampung pesisir yang tinggal diluar kabupaten Pesisir Barat” (Setiawan, 2019: 21). Secara etimologi Ngejalang berasal dari kata Jalang atau Jaring yang berarti menjaring harapan. Menjaring harapan yang dimaksudkan disini ialah Berdoa atau kirim doa melalui prosesi ziarah kubur yang dilakukan saat pelaksanaan prosesi Ngejalang. Tradisi Ngejalang dalam perspektif budaya dapat dimaknai sebagai wujud dari sistem sosial karena mengandung aktivitas dan tindakan berpola pada masyarakat setempat. Dari pengertian tersebut dapat dikatakan bahwa Ngejalang merupakan suatu tradisi yang ada dalam masyarakat, karena dalam waktu pelaksanaannya, Ngejalang dilakukan setiap tahun pada bulan Syawal dan dilakukan dari generasi kegenerasi sebagai bentuk kebiasaan yang diwariskan secara turun-temurun
BLANDED LEARNING DI ERA NEW NORMAL
Authors: Mahrunnisya Dyanti
Published: March 2023

Blended Learning is a learning innovation that combines technological advances in accordance with the demands of learning in the 21st century and is relevant to the learning transition period of offline to online learning, online to offline due to the covid-19 pandemic. This study aims to describe the implementation of blended learning learning. The method used in this research is the Systematic Literature Review (SLR), with a qualitative descriptive approach to the results of several studies with secondary data. Based on the results of the discussion, the application of blended learning is one solution that can be used in learning today by using various kinds of online applications, web, streaming, video, and so on.
Translator of Indonesian Sign Language Video using Convolutional Neural Network with Transfer Learning
Authors: Shania Sesilia , Farid Naufal Mohammad , Riandaru Prasetyo Vincentius , Bin Azmi Mohd Sanusi
Published: March 2023

Sign language is a language used to communicate by utilizing gestures and facial expressions. This study focuses on classification of Bahasa Isyarat Indonesia (BISINDO). There are still many people who have difficulty communicating with the deaf people. This study builds video-based translator system using Convolutional Neural Network (CNN) with transfer learning which is commonly used in computer vision especially in image classification. Transfer learning used in this study are a MobileNetV2, ResNet50V2, and Xception. This study uses 11 different commonly used vocabularies in BISINDO. Predictions will be made in real-time scenario using a webcam. In addition, the system given good results in the experiment with an interaction approach between one pair of deaf and normal people. From all the experiments, it was found that the Xception architectures has the best F1 Score of 98.5%.
Meranti Island E-Government Master Plan: A Root Cause and SWOT Analysis
Authors: Wahyuningrum Tenia , Fitriana Gita Fadila , Bahtiar Arief Rais , Ardani Aina Azalea , Imelda Imelda , Soares Teotino Gomes
Published: March 2023

The government has established a development program for the development of Information and Communication Technology with the term e-government. The implementation of e-government in government governance and public services certainly requires the use of information and communication technology (ICT) along with reliable human resources to manage it. There is still a reasonably high gap between the EBGS maturity level of the central agency and the index, and the local government is a challenge for the Meranti Islands Regency. To realize its vision and mission, the Meranti Islands Regency has made various efforts for transparency, accountability, good governance, and efficiency of government administration supported through ICT. The purpose of this research is the mapping of ICT utilization data in Meranti Islands Regency and the results of the identification of the obstacles that occur using GAP Analysis. GAP analysis uses Root Cause Analysis (RCA) and SWOT analysis for its analysis. The GAP analysis results show that based on the SWOT analysis, 18 strengths, 19 weaknesses, 12 opportunities, and 12 thread ats in the application of ICT are obtained, which are divided into 6 components. Based on the Root Cause Analysis, it was found that the main problem was caused by the low capacity of human resources in the application of ICT, as well as insufficient hardware/software requirements. For the study results study, it can be concluded that a SWOT analysis equipped with Root Cause Analysis can be used for strategic planning for implementing EBGS in the next fiveyears.
An Investigation of Nurses' Perceptions of the Usefulness and Easiness of Using Electronic Medical Records in Saudi Arabia: A Technology Acceptance Model
Authors: Alhur Anas
Published: March 2023

Abstract. EMRs play an essential role in documenting clinical information. Nurses are integral to the success of an EMR implementation, as they are the largest group of employees in a hospital and provide patient care. A major factor in the success of EMR implementation is nurses' acceptance of the system. This study is designed to measure nurses' willingness to use EMRs in clinical practice, determine factors influencing nurses' acceptance of EMR documentation in clinical practice, and gain an understanding of the nurses' perspective on EMRs to encourage the adoption and implementation of EMRs in other health facilities in Saudi Arabia. This study included nurses from Hail General Hospital, Maternity and Children Hospital, King Khalid Hospital, and Hail General Hospital. Study results indicate that perceived usefulness and ease of use are strongly correlated, resulting in nurses' greater acceptance of EMRs. According to the study results, nurses are willing to use EMRs. Our result shows that overall, nurses find the EMR useful in their jobs, with 40.9% agreeing and 24.4% strongly agreeing. Whereas the overall easiness was 9.4% agreed and 24 strongly agreed. Nurses need to be prepared for a demanding workplace through their nursing curriculum. Nursing students and professionals should understand the importance of EMRs in ensuring high-quality, effective, and efficient patient care. It is imperative that nurses continuously improve their computer skills to keep up with technological advancements.
Analisis pengaruh kecepatan udara masuk PAWG terhadap volume kondensat, kinerja sistem, Psys dan COP
Authors: Tarigan Ben V. , Gere Yohanes V. , Jafri Muhamad , Riwu Defmit B.N. , Adoe Dominggus G. H.
Published: March 2023

Water is one of the natural resources that is needed for the life of living things. Almost all activities require clean water, both for the metabolism of living things, agriculture and industry and is a major need. So that the availability of clean water sources needs to be maintained and looking for new sources. One source of clean water is atmospheric air which is very abundant. By using a water generator from stable atmospheric air, where the air enters the PAWG system in which there is a thermoelectric which can form a temperature difference in order to convert water into water vapor which then becomes condensate. The PAWG performance tested here is the inlet air velocity with variations of 0.27 m/s, 0.52 m/s and 0.97 m/s. The results show that the inlet air velocity affects the volume of condensate water and the performance of the Psys and COP systems. The higher the air velocity, the greater the volume of condensate water generated and the higher the Psys. But the results are different for COP, where the highest COP occurs at an inlet air speed of 0.52 m/s followed by a speed of 0.27 m/s and the smallest is 0.97 m/s.
KEANEKARAGAMAN IKAN AIR TAWAR DI SUNGAI SAKTI BUANA, KABUPATEN LAMPUNG TENGAH
Authors: Efendi *Niko , Carolina Hifni Septina
Published: March 2023

Sungai Sakti Buana memiliki potensi keanekaragaman ikan air tawar yang belum pernah diidentifikasi spesiesnya. Penelitian ini bertujuan untuk mengidentifikasi jenis ikan air tawar, mengukur indeks keanekaragaman, indeks keseragaman, dan indeks dominansi yang ada di Sungai Sakti Buana. Metode penelitian yang digunakan yakni eksploratif, jenis ikan diidentifikasi menggunakan berbagai referensi yang bersifat valid, dan data dianalisis menggunakan rumus Shannon Wiener. Hasil dari penelitian ini mendapatkan 20 spesies ikan yang berhasil teridentifikasi dengan nilai indeks keanekaragaman sebesar 2,48, indeks keseragaman mencapai 0,83, dan indeks dominasi sebesar 0,12. Penting adanya penelitian lanjutan dengan melakukan pengulangan dalam pengambilan sampel dan menambah titik lokasi penangkapan ikan.

Kata Kunci: ikan air tawar, keanekaragaman, Sungai Sakti Buana
Mathematical Modeling of the Solubility of Carbon Dioxide in Deep Eutectic Solvents
Authors: Shahla Z. Ahmad  , Arkan J. Hadi  , Shagull M. Ali
Published: March 2023

The increase in energy consumption, along with an increase in human population and industrial activities after the industrial revolution, has caused to increase in the consumption of fossil fuels. Carbon dioxide from fossil fuels has the most significant effect on the production of greenhouse gases and global warming. The absorption of CO2 emitted into the atmosphere is the most crucial method to reduce carbon dioxide in the air. Recently, a new solvent has been developed to absorb greenhouse gases under the name of deep eutectic solvents (DES). These solvents are biodegradable, non-toxic, or low-toxic compounds that are easily obtained. A mathematical model based on the Peng–Robinson (PR) equation of state (EOS) with three different mixing rules Modified van der Waal's (M1), Quadratic (M2) and Wong Sandler (M3) was developed to correlate the CO2 solubility in six types of DESs. The model was validated and compare with the obtained experimental data reported in the literature at temperatures (293.15 – 333.15) K and pressure (0.405 – 30.408) bar. The experimental and calculated data of PR EOS with three mixing rules were generally in a good agreement by obtaining % AARD a round (0.08 – 8.08), (0.05 – 7.58) and (0.09 – 6.56) for M1, M2 and M3 respectively, and the best results with less %AARD was obtained from Wong-Sandler mixing rule in the most of cases.
Pengaruh Edukasi Gizi Terhadap Pengetahuan Dan Self Management Pada Penderita Diabetes Melitus Tipe 2
Authors: Syarfaini  , Anwar Ibrahim Irviani , Syahrir Sukfitrianty , Edar Ika Wahyuni , Rini Jusriani  , Adha A. Syamsiah , Yusriyanto
Published: March 2023

Menurut International Diabetes Federation (IDF) tahun 2019 ditemukan sebanyak 463 juta orang menderita diabetes. Tujuan penelitian ini untuk mengetahui pengaruh edukasi gizi terhadap tingkat pengetahuan dan self management pada penderita diabetes melitus tipe 2 di Puskesmas Somba Opu tahun 2020. Jenis penelitian yang digunakan yaitu kuantitatif dengan penelitian pre post one group design, dan pendekatan quasy experiment. Teknik pengambilan sampel accidental sampling dengan jumlah sampel 45 orang penderita diabetes melitus tipe 2. Pengumpulan data yang digunakan menggunakan kuesioner, media video dan leaflet. Analisis data yang digunakan terdiri dari 2 tahapan yaitu univariat dan bivariat (uji Anova dan uji Friedman). Hasil penelitian ini menunjukkan bahwa Tidak ada pengaruh edukasi gizi terhadap tingkat pengetahuan pre test di setiap kelompok intervensi (p ꞊ 0.155), Ada pengaruh edukasi gizi terhadap tingkat pengetahuan post test nilai p = 0.001, tingkat self management pre test (p = 0.001) dan tingkat self management post tes  (p = 0.000) pada setiap kelompok intervensi pada penderita diabetes mellitus tipe 2. dengan kejadian diabetes melitus diharapkan bagi petugas kesehatan agar dapat lebih meningkatkan program dalam bidang penyuluhan dan diberikan edukasi terkait cara terapi diet pemilihan makanan.
X-linked agammaglobulinemia: a review of literature and a case report
Authors: Mgdsyan E. K. , Yukhacheva D. V. , Malakhova E. A. , Pershin D. E. , Kieva A. M. , Raikina E. V. , Kondratieva N. M. , Alekseeva E. I. , Rodina Yu. A. , Shcherbina A. Y.
Published: March 2023

X-linked agammaglobulinemia (XLA), or Bruton’s agammaglobulinemia, – is a primary immunodeficiency, caused by defects in the BTK gene encoding Bruton’s tyrosine kinase. The BTK defects lead to the arrest of B-lymphocyte development and, as a result, agammaglobulinemia. The disease manifests with recurrent infections starting in infancy. The gold standard of XLA treatment – intravenous or subcutaneous immunoglobulin substitution – proved effective in various multicenter studies and increases the quality of life of XLA patients. However, there are cases of delayed disease verification, and untimely delayed treatment, which leads to severe, recurrent infections and life-threatening conditions. We present a review of the literature and case report of an XLA patient with ecthyma gangrenosum. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.
Heart failure as a manifestation of acute lymphoblastic leukemia
Authors: Anderzhanova L. Kh. , Rybalko N. A. , Shatsky M. A. , Tikhomirova E. A. , Myakova N. V.
Published: March 2023

Clinically significant myocardial infiltration by blast cells is a rare occurrence in acute leukemia. Heart failure rate in children with hemato-oncological diseases is unknown. Here we report a clinical case of an 8-year-old female patient with B-cell acute lymphoblastic leukemia as well as heart failure that resolved during specific therapy for the cancer. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.
Progressive transformation of germinal centers or nodular lymphocyte-predominant Hodgkin lymphoma? Issues of differential diagnosis: a clinical case
Authors: Senchenko M. A. , Abramov D. S. , Myakova N. V. , Konovalov D. M.
Published: March 2023

Progressive transformation of germinal centers (PTGC) is a benign reactive lymphadenopathy, which can be an independent disease or occur in association with other lymphomas, the most common variant of which is nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). To date, it has not been definitively clarified how PTGC and NLPHL are interconnected, despite the abundance of works presented on this topic. PTGC may precede NLPHL, occur synchronously with it, or develop after a course of therapy in patients with NLPHL. Despite similar clinical and morphological features, the approach to the treatment and management of patients is different. In the case of NLPHL, one of the therapeutic options is chemotherapy, which is not used in patients with PTGC. This article presents a clinical case of partial lymph node lesion of NLPHL associated with PTGC, on the example of which the main issues of differential diagnosis of PTGC and NLHLP will be considered. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.
The role of blinatumomab in the treatment of B-cell relapses of acute lymphoblastic leukemia in children: own experience
Authors: Vavilova L. A. , Dyakonova Yu. Yu. , Bydanov O. I. , Myakova N. V. , Abugova Yu. G. , Anderzhanova L. Kh. , Evstratov D. A. , Kurnikova E. E. , Popov A. M. , Olshanskaya Yu. V. , Maschan M. A. , Shelikhova L. N. , Litvinov D. V. , Popa A. V. , Karachunskiy A. I.
Published: March 2023

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Despite remarkable improvements in the treatment of pediatric acute lymphoblastic leukemia over last years, relapse still carries a poor prognosis with considerable morbidity and mortality. New immunotherapeutic approaches will change the way we treated our patients and the results we had. Blinatumomab is a bispecific T-cell-engaging antibody indicated for the treatment of relapsed/refractory B-cell lymphoblastic leukemia. The use of Blinatumomab in relapsed B-cell ALL has shown promising effects, especially as a bridging tool to hematopoietic stem cell transplantation. The therapy results for patients in the high risk group remain far from optimal due to refractoriness to chemotherapy, death from infectious complications, as well as acute chemotherapy toxicity. This article demonstrates the results of our experience of using Blinatumomab in children with the high-risk group relapsed B-cell ALL treated according to the ALL-REZ 2016 protocol. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. The efficacy and toxicity of innovational blocks with the use of fludarabine and clofarabine with subsequent Blinatumomab infusion are shown. And we present the efficacy of autologous CD3+ lymphocytes infusion once a week during the continuous blinatumomab therapy. Also we demonstrate the results of using Blinatumomab for the treatment of patients with refractory to the first line therapy relapsed B-lymphoblastic leukemia and patients with a second relapse of B-cell ALL. The first line therapy in these patients was carried out according to the ALL-REZ 2014 protocol. Our results show an improved reduction in minimal residual disease in patients with refractory relapsed B-cell ALL as well as an increased event free survival in children with the high-risk group relapsed B-cell ALL.
Bone marrow cellularity assessment using magnetic resonance imaging in children with aplastic anemia
Authors: Kriventsova N. A. , Tereshchenko G. V.
Published: March 2023

Aplastic anemia is a life-threatening condition characterized by the suppression of all hematopoietic lineages in the bone marrow. Empty intertrabecular spaces are replaced by adipose tissue. With modern MR techniques for assessing fat fraction, it has become possible to capture these changes. The fat fraction is estimated as the ratio of the signal intensity from fat to the sum of the fat and water signals. Aim of the study: to assess the diagnostic value of bone marrow fat fraction quantification in patients aged < 18 years with aplastic anemia. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Healthcare of the Russian Federation. The study included 66 participants aged under 18 years. A control group consisted of 33 healthy subjects with a mean age of 13.03 ± 2.83 years. A group of interest included 33 children with a confirmed diagnosis of aplastic anemia, with a mean age of 12.31 ± 4.39 years. The study was carried out at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Healthcare of the Russian Federation; all scanning was performed on a Philips Achieva 3.0T MRI scanner using the mDixon-quant sequence in the iliac bones and lumbar vertebrae. Our results showed that bone marrow fat fraction was significantly higher in the aplastic anemia group than in the controls. In the patients with aplastic anemia, the mean fat fraction values in the iliac bones and in the L4, L5 vertebrae were 82.62 ± 10.92% and 73.52 ± 17.52%, respectively. In the control group, the mean fat fraction values for these sites were 51.04 ± 11.41% and 31.43 ± 10.61%, respectively. We found a significant difference in fat fraction values for the same sites between the groups (p < 0.01). Bone marrow fat fraction quantification by MRI allows for the detection of decreased cellularity of the marrow in patients under 18 years of age with aplastic anemia compared to healthy children.
The prevalence of rare bleeding disorders among children in the Russian Federation
Authors: Zharkov P. A. , Florinskiy D. B. , Aleynikova O. V. , Novichkovа G. A.
Published: March 2023

Rare bleeding disorders account for about 3–5% of all inherited bleeding disorders. Due to the rarity and complexity of diagnosing these disorders, their prevalence estimates vary greatly. There is currently no national registry of rare inherited bleeding disorders and their prevalence across the country has not been studied yet. Aim: to estimate the prevalence of rare coagulation disorders among Russian children. For this multicenter study, we used retrospective anonymous patient data collected during clinical practice, so the approval of the ethics committee was not required. We analyzed completed questionnaires containing the number of patients with rare bleeding disorders aged from 0 to 18 years from 72 subjects of the Russian Federation. The survey had been conducted from April to June 2022. Our analysis included patients with deficiencies of factor I, II, V, VII, X, XI or XIII, as well as with combined factor deficiencies and unspecified hemorrhagic conditions. According to the reported data, the total number of children with rare bleeding disorders is 398. The most common disorder is deficiency of factor VII (52%, n = 210); it is followed by fibrinogen deficiency (16%, n = 63) and deficiency of factor X (12%, n = 48). Deficiencies of factors XI, V and XIII account for 9% (n = 35), 5% (n = 20), and 4.5% (n = 18) of all cases, respectively. Combined factor deficiency was diagnosed in 1.7% of patients (n = 7) and factor II deficiency was detected in only 1% of patients (n = 4). In order to determine the actual prevalence and incidence of rare coagulation disorders and their clinical manifestations and to identify the need for factor concentrates, it is necessary to establish a national registry of rare bleeding disorders, following the example of the national hemophilia registry.
The assessment of the efficacy and safety of the personalized rehabilitation of the second stage using modern methods and technologies in children with primary immunodeficiencies
Authors: Mgdsyan E. K. , Rodina Yu. A. , Abrosimov A. B. , Zhukovskaya E. V. , Karelin A. F. , Shcherbina A. Y. , Novichkova G. A.
Published: March 2023

Primary immunodeficiencies (PID) are genetically determined defects of the immune system. Despite significant advances in diagnosis and treatment of this group of disorders, personalized rehabilitation therapy aimed at improving the quality of a patient’s life (QOL) is not standardized. Our study of the rehabilitation effectiveness in a group of PID patients (n= 78; 59 boys and 19 girls), treated at the Russkoe Pole Rehabilitation Center, demonstrated significant improvement of the QOL in all aspects. The total QOL scale score increased from 66.13 to 74.89 points according to a child form and from 65.37 to 70.86 points according to a parent form. The greatest improvement in the QOL was achieved in children under 12 years of age, with an increase in the total scale score from 63.22 to 74.95 points (child form), and from 63.24 to 71.34 points (parent form). Therefore, personalized rehabilitation therapy can improve the QOL of patients with PID and can be applied in various rehabilitation centers. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation.
Rosai–Dorfman disease (sinus histiocytosis with massive lymphadenopathy): personal observations and literature review
Authors: Rudneva A. E. , Abramov D. S. , Sharlay A. S. , Likar Yu. N. , Vorozhtsov I. N. , Myakova N. V.
Published: March 2023

Rosai–Dorfman disease (RDD) is a rare histiocytic disorder, which occurs at any age, can affect almost any organs and tissues, does not have pathognomonic symptoms and could be confirmed only by histological examination of the affected tissue. The article describes the successful treatment of a child with RDD with lymph nodes, nasopharynx, subcutaneous tissue, spleen and bones involvement, by multistep surgical treatment and chemotherapy. A review of the literature is provided, including recommendations for the examination and treatment of patients with RDD. The patient's parents agreed to use the information, including the child's photo, in scientific research and publications.
UN Treaty on Business and Human Rights or Investor-State Arbitration? A Sober Answer for the Better Protection of Human Rights
Authors: Suppa Alessandro
Published: March 2023

The concept of legal personality has been and is currently the object of studies. The doctrine is vast and made of many convincing interpretations. For this reason, an excursus of the main theories will be outlined in the light of recent events which support a specific theoretical orientation. The study will give a clear understanding of how international legal personality applies to Non-State Actors. After removing minor doctrines from the equation, those that remain will be highlighted, and compared with how the same matter is de facto faced in international investment law. The relationship between international investment law and international human rights law with regards to the role played by investors will be scrutinised. In investment arbitration, the position of the State and the investor is equal. This leads to the impression that international investment law is the realm in which to ensure more protection for the victims of human rights violations by business enterprises. So, if respect for international human rights is incorporated into the investment arbitral dispute procedures it could protect and or prevent human rights abuses. The opposite approach is to view business activities as objects. In this case, the role to regulate companies and protect stakeholders will be only on the state, and companies will be indirectly obliged to respect human rights. Therefore, the current draft of the binding treaty on business and human rights will be taken into consideration. The analysis of the two approaches will highlight which represents the more stable option for preventing, protecting and remedying human rights abuses by business enterprises. Specifically, the main questions to be answered are: is the international investment law’s field the future for more effective protection of human rights violations coming from business activities? Or is it a states’ prerogative to set and impose rules to prevent and protect such violations?