bluuebunny/crossref_metadata_2025 huggingface dataset:
A Machine Learning Language to Build a QSAR Model of Pyrazoline Derivative Inhibitors Targeting Mycobacterium tuberculosis Strain H37Rv
Authors: Thangavelu Prabha , Venkatesan Jayaprakash , Jubie Selvaraj , Jayapalan Sudeepan , Sivakumar Thangavel
Published: April 2022

Background:

Machine learning has become an essential tool for drug research to generate pertinent structural information to design drugs with higher biological activities. Quantitative structureactivity relationship (QSAR) is considered one technique. QSAR study involves two main steps: first is the generation of descriptors, and the second is building and validating the models.

Aim:

By using a Python program language for building the QSAR model of pyrazoline derivatives, the data were collected from diverse literature for the inhibition of Mycobacterium tuberculosis. Pyrazoline, a small molecule scaffold, could block the biosynthesis of mycolic acids, resulting in mycobacteria death and leading to anti-tubercular drug discovery.

Methods:

We have developed a new Python script that effectively uses CDK descriptor as the independent variable and anti-tubercular bioactivity as the dependent variable in building and validating the best QSAR model. The built QSAR model was further cross-validated by using the external test set compounds. Then, the three algorithms, viz. multiple linear regression, support vector machine, and partial least square classifiers, were used to differentiate and compare their r2 values.

Results:

Our generated QSAR model via an open-source python program predicted well with external test set compounds. The generated statistical model afforded the ordinary least squares (OLS) regression as R2 value of 0.514, F value of 5.083, the adjusted R2 value of 0.413, and std. error of 0.092. Moreover, the multiple linear regression showed the R2 value of 0.5143, reg.coef_ of, -0.07795 (PC1), 0.01619 (PC2), 0.03763 (PC3), 0.07849 (PC4), -0.09726 (PC5), and reg.intercept_ of 4.8324. The performance of the model was determined by the support vector machine classifier of sklearn, module and it provided a model score of 0.5901. Further, the model performance was supported by a partial least square regression, and it showed the R2 value of 0.5901. The model performance was validated, and the model predicted similar values when compared to that of the train set, and the plotted linear curve between the predicted and actual pMIC50 value showed all data to fall over the middle linear line.

Conclusion:

We have found that the model score obtained using this script via three diverse algorithms correlated well, and there was not much difference between them; the model may be useful in the design of a similar group of pyrazoline analogs as anti-tubercular agents.
An Insight into the Recent Synthetic Approaches of Benzimidazole Motifs
Based on Divergent Substrate Scope
Authors: Kavya G. , Nair Ajil R. , Sivan Akhil
Published: April 2022

Simple heterocyclic moieties are quite famous in synthetic organic chemistry due to their bioavailability, ease of laboratory synthesis, and variety of applications in multidisciplinary fields. Benzimidazole is an N-containing benzofused chemical compound with the formula C7H6N2 and belongs to the family of heterocyclic aromatic organic compounds. It is a potent bioactive molecule with prominent therapeutic activities and found to have prior importance in medicinal chemistry. Several advanced investigations in this area also proved that benzimidazole and its derivatives have significant antimicrobial, antiparasitic, antifungal, and anti-carcinogenic activities. It has also gained popularity in material science as well. Because of its versatile applications, numerous research groups paid considerable attention towards the synthesis of benzimidazoles. o-Phenylenediamine (OPD) is considered as the traditional substrate for benzimidazole synthesis. In this review, we discussed the synthetic approaches of benzimidazoles from OPD as a primary reactant with diverse substrates like aldehydes, alcohols, carboxylic acids/esters, etc. We have also briefed up reactions which uses the primary substrates such as o-nitroanilines and o-dinitro benzenes. This review report covers research findings which are published from 2016 till date and describes numerous practical and greener methods of synthesis. It also narrates innovative biocatalysts, photocatalysts and nano-catalysts, which are used for the synthesis of benzimidazoles.
Attenuation of Free Radicals and Exhibition of Antibacterial Activity by
Traditionally used Volatile Oils
Authors: Mishra Arun Kumar , Asif Mohd. , Sagar Anesh , Singh Harpreet , Mishra Amrita
Published: April 2022

Background:

This study aimed to isolate and analyse the essential oils of Eugenia caryophyllus
flower buds and Citrus reticulata peels for antioxidant and antibacterial properties.

Methods:

By using the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical method and
the ferric reducing antioxidant power (FRAP) method, the antioxidant activities of total volatile oil
components of both oils were assessed. Agar well diffusion and dilution were used to test antibacterial
activity.

Results:

Optical rotation (0.95 and 1.01), weight per mL (1.03 and 1.06), and refractive index
(1.52 and 1.53) were all tested for both oils. The existence of a total of 26 and 28 most important
volatile chemical components in oils produced from Eugenia caryophyllus and Citrus reticulata,
respectively, was determined by GC-MS chemical analysis of the total volatile component. Retention
time in a Gas Chromatography (GC) technique was used to identify the components. The mass
spectral database was used to identify the values of oil components. The predominant components
were eugenol (77.08%) in Eugenia caryophyllus oil and limonene (78.46%) in Citrus reticulate oil.
Eugenia caryophyllus oil has strong antibacterial action against microorganisms like S. pyrogenes,
with a ZOI of 15.90–26.84 mm, followed by oil from Citrus reticulata peels with a ZOI of 14.60-
22.82 mm.

Conclusion:

The presence of terpenes and phenolics in both essential oils resulted in substantial
antioxidant activity. Agar well diffusion and dilution were used to test antibacterial activity. In the
concentration range of 5–100 mg/mL, both essential oils demonstrated good bacteriostatic and
bactericidal activity against microbial strains.
Formulation Development and Optimization of Blonanserin Liquid
SMEDDS using D-Optimal Mixture Design
Authors: Vaghela Sohansinh , Chaudhary Sunita , Chaudhary Ankit
Published: April 2022

Background:

Blonanserin is an atypical antipsychotic potent antagonist of dopamine-D2
and D3 receptors with low aqueous solubility BCS class II drugs.

Objective:

The present research aims to develop and optimize the Blonanserin-loaded liquid selfmicro
emulsifying drug delivery system (SMEDDS) to improve its in vitro drug release by D-optimal
mixture design.

Methods:

Saturation solubility of Blonanserin was checked in various oils, surfactants, and cosurfactants.
The pseudo-ternary phase diagram was developed to identify the region of the microemulsion.
Trial batches were designed to determine dependent and independent variables in the formulation. DOptimal
Mixture design applies for optimization and minimized trials. The amount of oil(X1), surfactant(
X2), and co-surfactant(X3) were selected as independent variables, and solubility(Y1) and in vitro
percentage cumulative drug release(Y2) and size of globule(Y3) after 250 times dilution were selected
as the dependant variable. The level of the independent variables in the design will be selected based
on the drug's phase diagram, trial batches, and solubility. The developed SMEDDS was then evaluated
for globule size, transparency, self-emulsification time, in vitro dissolution, and relative dissolution of
the final formulation with marketed products and a pure drug.

Results:

BLN shows the highest solubility in (1:1) Captex 200P: Capmul MCM (oil), Tween 20 (surfactant),
and Ethanol (cosurfactant). Trial batches were shown at 1:9, 2:8, and 3:7 oil to surfactant and
cosurfactant ratios suitable for optimization. Optimization using a D-optimal mixture design gives 11
run batches and the resulting surface and contour plot suggest the best design space. The optimized
formula given by the mixture design of the target formulation had maximum drug solubility, maximum
drug release, and minimum globule size. Optimized formula containing Blonanserin, Captex
200P: Capmul MCM (1:1) Mixture (23% v/v), Tween 80 (57% v/v), and Ethanol (20% v/v) having
94.72% in vitro diffusion within 30 min with 21 nm globule size. Optimized liquid SMEDDS have a
higher in-vitro diffusion rate than marketed products and pure drugs.

Conclusion:

Blonanserin liquid SMEDDS was successfully developed with high solubility, nanoglobule
size, and improvement in in-vitro diffusion rate and vice versa for improvement in bioavailability
of the drug.
Splenic Gaucheroma Leading to Incidental Diagnosis of Gaucher Disease in
a 46-Year-Old Man with a Rare GBA Mutation: A Case Report
Authors: Erdal İzzet , Yıldız Yılmaz , Önal Gizem , Aktepe Oktay Halit , Düzgün Selin Ardalı , Sağlam Arzu , Emre Serap Dökmeci , Sivri Hatice Serap
Published: April 2022

Background:

Gaucher disease is a common lysosomal storage disease caused by the
deficiency of the β-glucosidase enzyme, leading to sphingolipid accumulation in the
reticuloendothelial system in Gaucher cells. Clinical findings are quite variable and some patients
may remain asymptomatic lifelong. However, even when patients have mild symptoms, there is
a significant increase in their quality of life with enzyme replacement therapy. We aimed to reveal
the relationship between a rare mutation in the Glucosylceramidase Beta (GBA) gene and clinical
signs and symptoms. Another aim of the study was to show the effect of enzyme replacement
therapy on the quality of life, even in patients with mild symptoms.

Case presentation:

Here, we report a 46-year-old male diagnosed with Gaucher disease based on
splenic Gaucheromas incidentally discovered in a cardiac computerized tomography scan. In
GBA gene analysis, the extremely rare R87W mutation was detected in a homozygous state. In
retrospect, the patient had nonspecific symptoms such as fatigue and bone pain for a long time,
which were substantially ameliorated by enzyme replacement therapy.

Conclusion:

In patients with adult-onset Gaucher disease, the symptoms may be mild, causing
significant diagnostic delay. Gaucher disease may be included in the differential diagnosis of
abdominal malignancies. Early diagnosis and treatment can improve quality of life and prevent
unnecessary procedures.
WITHDRAWN: Carbon-tunable p-type ZnO Nanoparticles for Enhanced
Photocatalytic Removal of Eriochrome Black T
Authors: Gaya Umar Ibrahim , Yusha’u Auwal
Published: April 2022

The article has been withdrawn at the request of the authors of the Journal of Photocatalysis.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
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authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Deaths Due to Cardiomyopathy of Unknown Etiology in Children and
Young Adults
Authors: Serinelli Serenella , White Steven M. , Arunkumar Ponni , Gitto Lorenzo
Published: April 2022

Background:

Cardiomyopathies are a group of diseases of the heart that can lead to
heart failure, cardiac arrhythmia, and sudden death. They typically manifest as an enlarged heart or
a normal heart with microscopic anomalies (fibrosis, inflammation, etc.). The aim of the study is to
investigate the prevalence of deaths due to cardiomyopathies of unknown etiology in young subjects
in a forensic pathology setting.

Materials and Methods:

Deaths due to cardiomyopathy in decedents less than 40 years old evaluated
at the Cook County Medical Examiner’s Office in Chicago from January 2013 to June 2018
were studied.

Results:

In total, 140 cases of cardiomyopathies were identified in the study period: among these,
in 20 cases (14%), no underlying etiology could be found through medical history and autopsy
investigation. The demographics and the macroscopic and microscopic findings of these cases are
described, highlighting the importance of medical history review and adequate histological sampling
of hearts in cases of sudden, unexpected death in children and young adults.

Conclusions:

This study highlights the importance of medical history review and adequate histological
sampling of hearts in cases of sudden, unexpected death in children and young adults to
identify possible cardiomyopathies of unknown etiology.
Development of Low Fat Mayonnaise Using Whey Protein as a Natural Emulsifier
Authors: Satriawan Tri Umar , Evanuarini Herly , Thohari Imam
Published: April 2022

Mayonnaise is an oil-in-water emulsion product that uses egg yolk as a stabilizer agent. Low-fat mayonnaise is made as a product modification to make it healthier by reducing fat. whey protein concentrate is given as a natural emulsifier. The objective of this study was to determine the effect of whey protein concentrate addition on low-fat mayonnaise based on carbohydrates, ash, fat content and emulsion droplets. The material used in this study was vegetable oil, and the addition of whey protein concentrate. This research used was a laboratory experimental method with a completely randomized design with 4 treatments and 5 replications. The treatments using control treatment without the addition of whey protein concentrate and treatment using whey protein concentrate as much as 5%, 10%, and 15% of the total use of oil. The variables measured were carbohydrate, ash, fat, antioxidants and emulsion droplets. The results showed that the use of whey protein concentrate in mayonnaise gave highly significant difference (p<0.01) in carbohydrate and fat content, gave a significantly different result (p<0.05) in the ash content, didn’t gave significant difference (p>0.05) in antioxidants and gave a highly significant difference (p<0.01) in the length of the emulsion droplet diameter so that it looked uniform in shape and size. The conclusion of this study is the use of whey protein concentrate as much as 15% produces the best low-fat mayonnaise
Application of Edible Coating of Durian Seed Starch Chitosan Composites With Kesum Leaves Extracts on Microbiological Quality And TVB-N of Beef Sausage
Authors: Lestari Retno Budi , Permadi Edy , Mulyadi Achmad
Published: April 2022

The edible coating is one alternative that has the potential to extend the shelf life of sausages. This study aimed to determine the effect of the type of packaging and the storage times of beef sausages at frozen storage. The study using the factorial completely randomized design (CRD) with two factors. The first factor is the type of packaging (K1: edible coating durian seeds starch-chitosan; K2: edible coating durian seeds starch-chitosan with kesum leave extract; K3: plastic LDPE). The second factor is storage time (L0: 0 months; L1: 1 month; L2: 2 months; L3: 3 months; L4: 4 months) with four replication. The research variable observed was the sausage quality like TPC (Total Plate Count) and TVB-N (Total Volatile Bases). The result showed that the treatment of type packaging, storage time, and the interaction had a very significant effect on TPC with the lowest value K3L0 (2.31 x 104 CFU/g) and the highest value K1L4 (11.79 x 104 CFU/g). And, it had a significant effect on TVB-N with the lowest K1L0 (9.19 mg/N/100 g) and the highest value K1L4 (50.93 mg/N/100 g). Edible coating of durian-chitosan seed starch with kesum leaf extract can extend the shelf life of beef sausage for four months at freezing temperature based on the TPC value of 9.65.104 cfu/g and TVB-N value 23.96 mg N/100 g.
FAMILIA LYCOPODIACEAE
Authors:   Universidad Nacional Autónoma de México, Tejero-Díez J. Daniel
Published: April 2022

Lycopodiaceae son un linaje monofilético, homospórico (Wikstrom y Kenrick, 2000, 2001; Judd et al., 2008), cuyos representantes actuales provienen de cladogénesis relativamente recientes (segunda mitad del Cretácico), mientras que la familia procede de eventos mucho más antiguos a partir de una división temprana de las plantas vasculares en el Carbonífero temprano (Wikstrom y Kenrick, 2001). La circunscripción taxonómica de los géneros de la familia ha tenido muchos cambios y actualmente se reconocen tres subfamilias (Huperzioideae, Lycopodielloideae y Lycopodioideae), 16 géneros y 388 especies (PPG I, 2016), de distribución global cosmopolita, pero con mayor diversidad en las zonas templadas y templado-frías de las montañas intertropicales. Aproximadamente la mitad de las especies se encuentra en América tropical (principalmente América del Sur). Para México se reconocen siete géneros con 21 especies (Mickel y Smith, 2004), de los cuales los siguientes taxones se encuentran, al menos probablemente, en el área de estudio.
Быстродействующий низкотемпературный газоанализатор импульсных выбросов сжиженного природного газа в атмосферу на основе иммерсионных диодных оптопар
Authors: Загнитько А.В. , Мацуков И.Д. , Пименов В.В. , Сальников C.Е. , Федин Д.Ю. , Алексеев В.И. , Вельмакин С.М.
Published: April 2022

A low-temperature infrared optical gas analyzer based on immersion diode optocouplers with a speed of less than 0.03 s has been developed to detect pulsed emissions into the atmosphere of explosive mixtures of liquefied natural gas and alkanes with air at a temperature of more than 150 K with the transfer of digitized data to a remote server. The design is described and its characteristics are given in the process of analyzing mixtures of air with pure methane, ethane, propane and LNG of various compositions. It is shown that the speed and operating temperature range of the gas analyzer exceed the parameters of foreign and domestic analogues for monitoring man-made LNG emissions into the atmosphere.
Магнетизм нанопористого углерода с кластерами марганца
Authors: Данишевский А.М. , Шанина Б.Д. , Шаренкова Н.В. , Гордеев С.К.
Published: April 2022

Theoretical calculations of the electron density (taking into account the spin) of a model 16-atom carbon cluster with a manganese atom in a micropore showed that it is energetically favorable for manganese atoms to localize inside the pore and form metal nanoclusters in the carbon micropore. The magnetic moment of an ensemble of atoms surrounding a micropore with one manganese atom in it turned out to be quite large.
An experimental method was proposed for introducing manganese clusters into bulk samples of nanoporous carbon with different porous structures, and the effect of these adsorbates on the magnetic properties of the samples was studied.
In parallel, X-ray diffraction studies of the samples were carried out. It has been shown that Mn clusters near the surface are rather rapidly oxidized in air, as a result of which peaks associated with oxides predominate in the X-ray diffraction patterns. However, small Mn clusters have also been found. Measurements of the dependence of the magnetization of the samples on the applied field at T=295K showed the presence of nonlinearity and hysteresis characteristic of superparamagnetism or ferromagnetism.
Треугольные кристаллы координационного полимера феназина: формирование, свойства
Authors: Компан М.Е. , Малышкин В.Г. , Бойко М.Е. , Шарков М.Д. , Сапурина И.Ю. , Шишов М.А.
Published: April 2022

Unusual quasi-two-dimensional crystals of a regular triangular shape, self-formed in the process of obtaining a coordination polymer based on phenazine and silver, are described and studied. X-ray diffraction studies were carried out, the interplanar distance was determined, and the spectra of Raman scattering were obtained. A mechanism is proposed that can cause the appearance of triangular crystals from nuclei of hexagonal symmetry.
Подобие ударно-волновых полиморфных переходов в системе кремнезема
Authors: Кинеловский С.А.
Published: April 2022

A set of experimental data on the thermodynamic parameters of polymorphic transitions in the silica system is considered. Analysis of these parameters in dimensionless form is performed. A fundamental result of the analysis is that the thermodynamic parameters of all silica polymorphs after transitions are described by a single universal Hugoniot of polymorphic transition. It is shown that the two-shock model of polymorphic transformations proposed earlier by the author describes all the results obtained in the analysis. A joint consideration of the experimental data and model calculations leads to the conclusion that during a polymorphic transformation, the density of the new phase is determined from the condition that the elastic pressure components after the first shock and after the polymorphic transition are equal.
Электроразрядный KrF-лазер с высокой удельной энергией излучения
Authors: Панченко Ю.Н. , Пучикин А.В. , Ямпольская С.А. , Андреев М.В. , Горлов Е.В. , Жарков В.И.
Published: April 2022

Results of experimental and numerical studies of an electric-discharge KrF laser with a specific pump power of 3.5 and 7 MW/cm3 are presented; in this case, lasing was obtained with a specific radiation pulse energy of ~ 6 and 9.5 J/l, with an internal energy efficiency of ~ 4%. Time dependences of the formation of charged and excited particles in a dense excimer plasma with an electron concentration of ne ~ 1016 cm-3 are shown. Conditions for the effective operation of the laser are proposed, which will make it possible to ensure a further increase in the specific radiation energy by more than two times while maintaining the high internal efficiency of the laser relative to the energy deposited into the discharge.
Video Game Addictive Symptom Level, Use Intensity, and Hedonic Experience: Cross-sectional Questionnaire Study
Authors: Walia Bhavneet , Kim Jeeyoon , Ijere Ignatius , Sanders Shane
Published: April 2022

Background

The effects of behavioral addiction to video games has received increasing attention in the literature, given increased use intensity among subgroups of video game players.

Objective

This study seeks to empirically determine the relationship between intensity of video gaming and hedonic experience of the player.

Methods

We conducted a survey of 835 individuals who regularly play video games to determine the relationship between intensity of use and hedonic experience. We divided the sample into quartiles by self-reported video game addictive symptom level (from the Internet Gaming Disorder Scale) and conducted polynomial regressions separately for each quartile.

Results

We found that the higher video game addictive symptom level groups experienced a U-shaped (curvilinear) relationship between hedonic experience and intensity of play, whereas groups with lower video game addictive symptom levels exhibited no such relationship. The coefficients for the highest addictive symptom level group (quartile 4) for marginal effects for hours played per week and hours played per week squared were significantly negative (P=.005) and significantly positive (P=.004), respectively.

Conclusions

Our results are consistent with sensitization and tolerance theories, which suggest that high-symptom groups experience frustration and disappointment until they achieve excessive dopamine release, at which point their hedonic experience is expected to improve with additional play. Conversely, low-symptom groups experience no such fall-and-rise pattern. This result is consistent with the outcome that members of the latter group play the game for the direct experience, such that their hedonic experience is more directly related to events occurring in the game than to the increasingly elusive pursuit of excessive dopamine release. We also find that high-symptom groups spend substantially more time and money to support video game use and are much more likely to engage in video game use at the expense of other important activities, such as working, sleeping, and eating.
Participants’ Perceptions of Essential Coaching for Every Mother—a Canadian Text Message–Based Postpartum Program: Process Evaluation of a Randomized Controlled Trial
Authors: Dol Justine , Aston Megan , McMillan Douglas , Tomblin Murphy Gail , Campbell-Yeo Marsha
Published: April 2022

Background

“Essential Coaching for Every Mother” is a Canadian text message–based program that sends daily messages to mothers for 6 weeks after they give birth. There is a need to explore the program’s effectiveness in terms of the participants’ experience to guide refinement and modification.

Objective

This study aimed to describe the process evaluation of the Essential Coaching for Every Mother randomized controlled trial through an evaluation of the research implementation extent and quality.

Methods

Participants were recruited from Nova Scotia, Canada, between January 5 and August 1, 2021. Enrolled participants were randomized into the intervention or control group. Participants randomized to the intervention group received standard care along with the Essential Coaching for Every Mother program’s text messages related to newborn and maternal care for the first 6 weeks after giving birth, while the control group received standard care. Usage data were collected from the SMS text message program used, and participants completed web-based questionnaires at 6 weeks after birth. ﻿Quantitative data and qualitative responses to open-ended questions were used to triangulate findings. Quantitative data were summarized using means, SDs, and percentages, as appropriate, while qualitative data were analyzed using thematic analysis.

Results

Of the 295 unique initial contacts, 150 mothers were eligible and completed the baseline survey to be enrolled in the study (intervention, n=78; control, n=72). Of those randomized into the intervention group, 75 (96%) completed the 6-week follow-up survey to provide feedback on the program. In total, 48 (62%) intervention participants received all messages as designed in the Essential Coaching for Every Mother program, with participants who enrolled late missing on average 4.7 (range 1-12) messages. Intervention participants reported an 89% satisfaction rate with the program, and 100% of participants would recommend the program to other new mothers. Participants liked how the program made them feel, the format, appropriate timing of messages, and content while disliking the frequency of messages and gaps in content. Participants also provided suggestions for future improvement.

Conclusions

Our process evaluation has provided a comprehensive understanding of interest in the program as well as identified preference for program components. The findings of this study will be used to update future iterations of the Essential Coaching for Every Mother program.

Trial Registration

ClincalTrials.gov NCT04730570; https://clinicaltrials.gov/ct2/show/NCT04730570
Conditions for the Successful Integration of an eHealth Tool "StopBlues" Into Community-Based Interventions in France: Results From a Multiple Correspondence Analysis (Preprint)
Authors: Turmaine Kathleen , Dumas Agnès , Chevreul Karine ,   PRINTEMPS Consortium
Published: April 2022

BACKGROUND

For over a decade, digital health has held promise for enabling broader access to health information, education, and services for the general population at a lower cost. However, recent studies have shown mixed results leading to a certain disappointment regarding the benefits of eHealth technologies. In this context, community-based health promotion represents an interesting and efficient conceptual framework that could help increase the adoption of digital health solutions and facilitate their evaluation.

OBJECTIVE

To understand how the local implementation of the promotion of an eHealth tool, StopBlues (SB), aimed at preventing psychological distress and suicide, varied according to local contexts and if the implementation was related to the use of the tool.

METHODS

The study was nested within a cluster-randomized controlled trial that was conducted to evaluate the effectiveness of the promotion, with before and after observation (NCT03565562). Data from questionnaires, observations, and institutional sources were collected in 27 localities where SB was implemented. A multiple correspondence analysis was performed to assess the relations between context, type of implementation and promotion, and use of the tool.

RESULTS

Three distinct promotion patterns emerged according to the profiles of the localities that were associated with specific SB utilization rates. From highest to lowest utilization rates, they are listed as follows: the privileged urban localities, investing in health that implemented a high-intensity and digital promotion, demonstrating a greater capacity to take ownership of the project; the urban, but less privileged localities that, in spite of having relatively little experience in health policy implementation, managed to implement a traditional and high-intensity promotion; and the rural localities, with little experience in addressing health issues, that implemented low-intensity promotion but could not overcome the challenges associated with their local context.

CONCLUSIONS

These findings indicate the substantial influence of local context on the reception of digital tools. The urban and socioeconomic status profiles of the localities, along with their investment and pre-existing experience in health, appear to be critical for shaping the promotion and implementation of eHealth tools in terms of intensity and use of digital communication. The more digital channels used, the higher the utilization rates, ultimately leading to the overall success of the intervention.

INTERNATIONAL REGISTERED REPORT

RR2-10.1186/s13063-020-04464-2
Reintroducing the Effortless Assessment Research System (EARS) (Preprint)
Authors: Lind Monika N , Kahn Lauren E , Crowley Ryann , Reed Wyatt , Wicks Geordie , Allen Nicholas B
Published: April 2022

UNSTRUCTURED

This paper reintroduces the Effortless Assessment Research System (EARS), 4 years and 10,000 participants after its initial launch. EARS is a mobile sensing tool that affords researchers the opportunity to collect naturalistic, behavioral data via participants’ naturalistic smartphone use. The first section of the paper highlights improvements made to EARS via a tour of EARS’s capabilities—the most important of which is the expansion of EARS to the iOS operating system. Other improvements include better keyboard integration for the collection of typed text; full control of survey design and administration for research teams; and the addition of a researcher-facing EARS dashboard, which facilitates survey design, the enrollment of participants, and the tracking of participants. The second section of the paper goes behind the scenes to describe 3 challenges faced by the EARS developers—remote participant enrollment and tracking, keeping EARS running in the background, and continuous attention and effort toward data protection—and how those challenges shaped the design of the app.
IBM Pengembangan Snack Cheese Stick Wirausaha Mahasiswa
Authors: Sari Novi Primita , Yuli Sri Budi Cantika
Published: April 2022

Mahasiswa lulusan perguruan tinggi saat ini tidak hanya dibekali ilmu akademik saja tetapi juga ketrampilan yang memadai. Salah satu ketrampilan yang diperkuat dalam proses pembelajaran adalah mengenai sikap entrepreneurship, dimana sikap ini adalah wujud dan harapan bahwa nantinya setelah lulus dari Perguruan Tinggi Ketika mahasiswa tidak segera terserap dalam pasar tenaga kerja setidaknya mereka mampu menjadi seorang yang handal dalam bisnis mereka.

Mahasiswa yang telah memulai dan memiliki usaha bisnis tentu sangat banyak kita jumpai, selain karena tugas mereka akhirnya menekuni dan menjadi sebuah passion yang mampu mendatangkan pasif income serta sarana bagi mereka untuk belajar. Geliat UKM yang dirintis oleh mahasiswa semakin nampak khususnya di Kota Malang, dari UKM kecil pinggiran hingga yang telah memiliki bisnis café elit. Tentu menjadi perhatian adalah bagaimana terus membekali mahasiswa dengan berbagai ketrampilan guna mengasah pengetahuan mereka dan inovasi yang lebih menarik mengikuti perkembangan jaman dan permintaan pasar agar tidak mudah terkikis oleh persaingan usahan bahkan produk sejenis
Daily work engagement and positive emotions in the workplace: Job crafting as a mediator
Authors: Wang DongYang
Published: April 2022

I combined the broaden-and-build and job demands–resources theories, and examined the effect of employees' daily positive emotions outside the workplace before work on work engagement, and the mediating roles of (a) seeking resources and challenges and (b) reducing demands, in
this daily job-crafting relationship. I collected data from 103 medical staff daily for 5 days, resulting in 515 data points, and used a multilevel model for data analysis. Results show that positive emotions directly and positively predicted work engagement, and also predicted work engagement
indirectly and positively through seeking resources and challenges. Further, the effect of positive emotions was mediated by job crafting during the day through seeking resources and challenges, but not through reducing demands. These results emphasize the importance in subsequent work engagement
of employees' emotions experienced in their personal life.
Socioaffective factors related to engagement in regular classes of academically gifted adolescent students in Taiwan
Authors: Wang Wen-Ling
Published: April 2022

Academically gifted adolescent students (N = 213) at 10 junior high schools in Taoyuan, Taiwan, completed a survey to examine the socioaffective factors associated with their engagement in regular classes. Structural equation modeling was performed for inferential statistical
analysis. The results show that the students' emotional intelligence was associated with their engagement in regular classes. In addition, teacher–student and peer relationships mediated the relationship between students' emotional intelligence and engagement. Therefore, emotional competencies
and interpersonal relationships may play a crucial role in promoting academically gifted adolescent students' engagement in regular classes.
Happy music and employee creativity in the workplace: Psychological safety as a mediator
Authors: Zhu Quan , Li Weicheng , Chen Yuxin
Published: April 2022

The importance of music is a key topic that has been studied in many disciplines. We examined the relationship between employees' perception of happy music and their creative performance, and explored the mediating effect of psychological safety in this link. Data were collected from 315 employees working in three large hotels located in Mainland China. We performed structural equation modeling to test the proposed research model. Results show that employees' perception of happy music was positively related to creative performance, and this relationship was mediated by perceived psychological safety. Therefore, employees produced creative outcomes while perceiving the happiness of music in the workplace, in part because they felt psychologically safe. Our findings offer organizations practical insight into how to promote employee creativity by using music as an effective tool for enhancing the quality of the work environment. Implications for future research are discussed.
PENGEMBANGAN PERANGKAT PEMBELAJARAN MATEMATIKA REALISTIK PADA MATERI OPERASI HITUNG BENTUK ALJABAR
Authors: Syahri Andi Alim , Halim St. Nur Humairah , Bahar Erni Ekafitria
Published: April 2022

Penelitian ini merupakan penelitian pengembangan (Research and Development) dengan ujicoba terbatas yang bertujuan untuk mengembangkan perangkat pembelajaran matematika dengan pendekatan realistik pada materi operasi hitung bentuk aljabar yang meliputi Rencana Pelaksanaan Pembelajaran (RPP), Lembar Kerja Siswa (LKS), dan Tes Hasil Belajar (THB). Subjek penelitian ini adalah siswa Kelas VII MTs. Al-Muhajirin Pallangga, dengan jumlah siswa sebanyak 32 orang. Prosedur pengembangan yang digunakan dalam penelitian ini adalah model Thiagarajan atau model 4-D yang dimodifikasi menjadi 3D meliputi tiga tahap, yaitu tahap pendefinisian (define), tahap perancangan (design), dan tahap pengembangan (development). Perangkat pembelajaran matematika dengan pendekatan realistik yang telah dikembangkan dan telah divalidasi serta mengalami revisi dan telah memenuhi kriteria kevalidan dan kepraktisan sehingga perangkat pembelajaran ini layak untuk digunakan. Hasil dari ujicoba terbatas menunjukkan bahwa (1) tingkat kemampuan guru mengelola proses pembelajaran matematika dengan pendekatan realistik termasuk dalam kategoti tinggi, artinya penampilan guru dapat dipertahankan; (2) dengan menggunakan perangkat pembelajaran matematika dengan pendekatan realistik, siswa jadi lebih aktif dalam proses pembelajaran; (3) pada umumnya siswa memberikan respons yang positif terhadap perangkat pembelajaran yang digunakan; (4) skor rata-rata yang diperoleh siswa pada tes hasil belajar adalah 77,83 dari skor ideal 100 dengan standar deviasi 7,420. Dimana 10 dari 12 siswa atau 83,33% memenuhi ketuntasan individu yang menunjukkan bahwa ketuntasan klasikal tercapai.
ANALISIS PEMAHAMAN KONSEPTUAL PECAHAN SISWA SMP KELAS VII BERGAYA KOGNITIF FI DAN FD
Authors: Rizal Muh , Awuy Evie , Linawati Linawati , Alfisyahra Alfisyahra
Published: April 2022

Tujuan penelitian ini untuk memperoleh deskripsi pemahaman konseptual pecahan siswa SMP kelas VII bergaya kognitif FI dan FD. Untuk mendapatkan data pemahaman konseptual pecahan siswa bergaya kognitif FI dan FD digunakan tes tertulis dan wawancara tidak terstruktur. Analisis data mengacu pada yang dikembangkan oleh Miles, Huberman dan Saladana (2014), yaitu condensation data, display data dan drawing and verifying conclusion. Hasil analisis menunjukkan bahwa siswa FI dan siswa FD melakukan penjumlahan pecahan biasa yang berpenyebut tidak sama dengan menyamakan penyebut menggunakan KPK, kemudian menyelesaikan menggunakan konsep penjumlahan pecahan berpenyebut sama. Dalam menyamakan penyebut, siswa FI langsung mengalikan penyebut kedua pecahan, sedangkan siswa FD terlebih dahulu mencari faktor dari masing-masing penyebut lalu mengalikan faktor-faktor tersebut.
Recombinant von Willebrand factor for perioperative bleeding management in pediatric patient with allergy to plasma-derived von Willebrand factor
Authors: Tran Thuy , Arnall Justin , Kleiboer Brendan , Hinson Ashley
Published: April 2022

Von Willebrand disease (VWD) is a hereditary bleeding disorder
characterized by a deficiency of von Willebrand factor (VWF). In
pediatrics, plasma-derived VWF (pdVWF) is the standard for factor
replacement when indicated. Alternatives are needed for kids who are
refractory or intolerant to pdVWF. There is limited data on the safety
and efficacy of recombinant VWF in the pediatric population, and none
regarding the switch from pdVWF to rVWF due to intolerance. Herein, we
describe the safe and effective use of rVWF in a pediatric patient with
history of anaphylaxis to pdVWF, who underwent elective orthopedic
surgery.
Reconstruction of molecular evolution of human influenza A H1N1/2009 virus in Iran and neighboring countries
Authors: Ghalekhani Nima , Bokaie Saied , Eybpoosh Sana , Akbarein Hesameddin , Sharifi Hamid
Published: April 2022

Background In this study, the time and path of transmission of H1N1
serotype influenza A viruses in Iran and neighboring countries have been
investigated by using Bayesian phylogeography analysis on the sequences
extracted from the gene bank. Methods We obtained all hemagglutinin (HA)
and neuraminidase (NA) nucleotide sequences of influenza H1N1 available
up to December 25, 2020, from Iran and its neighboring countries (i.e.,
Pakistan, Afghanistan, Turkmenistan, Armenia, Azerbaijan, Turkey, and
Iraq). We also performed a Bayesian Markov chain Monte Carlo method to
infer the evolutionary dynamic and the most recent common ancestor for
the HA and NA sequences. Results Based on the extracted sequences, the
age of emergence of H1N1 influenza virus serotype was older in Iran
compared to neighboring countries, and Tehran had a key role and
epicenter of transmission to other cities within Iran. The mean time of
the most recent common ancestor of H1N1 viruses was 1989 (95% HPD:
1980-1994) for HA and NA as well. Conclusions Along with ordinary
measures like resource management, diagnostic approaches, and
preparedness to fight against viruses that were in place, continuous
monitoring, and screening of H1N1 serotype influenza virus in the
country, especially by implementation of feasible, effective, and
innovative measures at border line should be initiated and identified
gaps and shortage that should be a priority for virus control. It is
also important for countries to have a regional monitoring program in
addition to internal monitoring programs, as well as to start a virus
molecular care program.
A pharyngeal foreign body resembling cervical emphysema
Authors: Nishiori Hironobu , Tohma Takayuki , Fujita Hisanori , Yamaguchi Seiichi
Published: April 2022

In the laryngeal foreign body caused by plate-shaped grilled liver,
computed tomography imaging showed the presence of air along the
pharyngeal wall between the wall and the meat, which can be mistaken as
pharyngeal emphysema.
The Butterfly Effect in Therapy: Not Every Flap of a Butterfly's Wing...
Authors: MEARA ALAN
Published: April 2022

This paper presents aspects of Complexity, particularly Chaos theory and self-organization, and explores their usefulness for the theory of Gestalt practice. Traditional systems theory is reviewed from Complexity's nonlinear systems perspective, and examples are given of how the theory may relate to practitioner experience in individual and group work. The self-organization process is described as a model of change where order emerges from the system itself, rather than being imposed externally. A way of researching self-organization dynamics in Gestalt personal development groups is outlined, and some early findings are presented.
Ecopsychology and Psychotherapy Within the Larger Context: Response to Jack Aylward's Article on Paul Goodman's Legacy
Authors: CONN SARAH A. , CONN LANE K.
Published: April 2022

Ecopsychology, which brings ecology and psychology together to develop new understandings of human health within the larger context of the earth as a living system, is a way of responding to Paul Goodman's invitation to psychotherapists to become "revolutionaries." In this response to Jack Aylward, we briefly define and describe ecopsychology as we have been working with it at The Ecopsychology Institute of The Center for Psychology and Social Change in Cambridge, MA. We elaborate on the contributions of this approach to the understanding of healthy selffunctioning and offer some examples of practices which grow out of the theory.
Risk and Control Considerations in Attestation Engagements: The Auditor’s Role in the Academy Awards
Authors: Bordeman Adam , Cussatt Marc , Westermann Kimberly D.
Published: April 2022

This case introduces students to engagement planning, risk management, independence, and execution in the setting of attestation engagements by examining the auditor’s role in the Academy Awards (also “the Oscars”). Specifically, this case focuses on an error made by PwC during the 89th Academy Awards ceremony in 2017, which resulted in the announcement of the wrong “Best Picture” winner (“the error”). Students are required to research attestation engagements and the AICPA Code of Professional Conduct, analyze the benefits and risks associated with the Oscars engagement, evaluate the controls that were in place, and think critically about what additional control considerations may have prevented the error. Finally, students are asked to assess the potential consequences of this error for the engagement partners, the firm, and its clients. The visibility of this error is a unique opportunity to evaluate the roles and responsibilities of accountants in practice.
Implanted Peroneal Nerve Stimulator Treatment for Drop Foot Caused by Central Nervous System Lesion: A Twelve-Month Follow-up of 21 Patients
Authors: Severinsen Kaare , Grey Kurt , Haase Juhl Anne , Soerensen Preben , Oppel Lorenz , Magnussen Ib , Tine Larsen Birgit
Published: April 2022

Objective: Drop foot is a common impairment following stroke or other causes of central pathology. We report data on patient self-perceived performance, satisfaction with performance, walking ability, and adverse effects after surgical implantation of the ActiGait® drop foot stimulator.Design: Prospective case study with a 12-month follow-up.Subjects: Twenty-one participants with drop foot caused by central nervous system lesion.Methods: The patients’ self-perceived performance and satisfaction with performance were evaluated using the Canadian Occupational Performance Measure (COPM). Walking ability was assessed using a 10-m walk test and a 6-min walk. Nerve conduction of the peroneal nerve was examined in 10 patients.Results: At follow-up, COPM self-percieved performance from 3.2 to 6.7 points, the median increase being 2.8 (interquartile range (IQR) 2.2–5.0), p < 0.001. Likewise, the COPM satisfaction with performance increased from 2.6 to 6.9 points, the median increase being 4.2 (IQR 2.8–5.8), p < 0.001. Walking velocity increased 0.1 m/s from a baseline measurement of 0.73 m/s (95% confidence interval (95% CI) 0.03–0.2), n = 21, p < 0.01, and walking distance increased by 33 m, from a baseline measurement of 236 m (95% CI 15–51), n = 21, p < 0.001.Conclusion: Stimulation of the peroneal nerve by an implantable stimulator increases self-perceived performance, satisfaction with performance, and ambulation in patients with long-lasting drop foot caused by a central nervous system lesion.
LAY ABSTRACTDrop foot is a common impairment following stroke or other causes of disease in the nervous system. This study of 21 patients with drop foot caused by various diseases in the central nervous system reports data on patient self-perceived performance, satisfaction with performance, walking ability, and adverse effects after surgical implantation of the ActiGait® peroneal nerve stimulator. The patients’ self-perceived performance and satisfaction with performance were evaluated using the Canadian Occupational Performance Measure. Walking ability was assessed using a 10-m walk test and a 6-min walk test before implantation and at follow-up. At follow-up, patient self-perceived performance, satisfaction with performance, walking velocity, and walking distance increased. No changes in nerve function were demonstrated. In conclusion, implantable peroneal nerve stimulation increases self-perceived performance, satisfaction with performance, and ambulation in patients with long-lasting drop foot caused by central nervous system lesion.