bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Context on EEG Motor Imagery Neurofeedback and Related Motor Domains
Authors: Daeglau Mareike , Zich Catharina , Kranczioch Cornelia
Published: August 2021

Neurofeedback (NF) is a versatile non-invasive neuromodulation technique. In combination with motor imagery (MI), NF has considerable potential for enhancing motor performance or supplementing motor rehabilitation. However, not all users achieve reliable NF control. While research has focused on various brain signal properties and the optimisation of signal processing to solve this issue, the impact of context, i.e. the conditions in which NF motor tasks occur, is comparatively unknown. We review current research on the impact of context on MI NF and related motor domains. We identify long-term factors that act at the level of the individual or of the intervention, and short-term factors, with levels before/after and during a session. The reviewed literature indicates that context plays a significant role. We propose considering context factors as well as within-level and across-level interactions when studying MI NF.
Consultation Phases in Mathematics Learning and Support Centres
Authors: Schürmann Mirko , Panse Anja , Shaikh Zain , Biehler Rolf , Schaper Niclas , Liebendörfer Michael , Hilgert Joachim
Published: August 2021

Mathematics Learning Support Centres are becoming more and more common in higher education both internationally and in Germany. Whereas it is clear that their quality largely depends on a functioning interaction in consultations, little is known about how such consultations proceed in detail. On the basis of models from the literature and recorded support sessions (N = 36), we constructed a process model that divides consultations into four ideal–typical phases. In the individual consultations, forward or backward leaps occur, but overall the model seems to describe the data well. A high intercoder reliability shows that it can be applied consistently on real data by different researchers. An analysis of the consultations between students and tutors shows that both mainly work on past attempts or thoughts of the students to solve the exercise or problems and on concrete strategies to solve a problem within the session. In contrast, very little time is dedicated to summarizing and reflecting the solution. The data allows for a more in-depth discussion of what constitutes quality in advising processes and how it might be further explored. Practically, the model may structure support sessions and help in focussing on different goals in different phases.
Recovery of Iron and Aluminum from Bauxite Residue by Carbothermic Reduction and Slag Leaching
Authors: Ekstroem K. E. , Bugten A. Voll , van der Eijk C. , Lazou A. , Balomenos E. , Tranell G.
Published: August 2021

The recovery of major components of bauxite residue by carbothermic reduction at 1550–1750 °C and subsequent slag leaching in a Na3CO3(aq) solution is studied. Iron recovers primarily to pig-iron and lime is added to tune the calcium aluminate slags towards the highly leachable mayenite phase. The concentration of aluminum in the leachate correlates well with the occurrence of mayenite and aluminum recoveries up to 50–60% are observed. However, slags with low CaO additions are vulnerable to gehlenite formation and display reduced leachabilities. Formation of an inhibiting layer of CaCO3(s) on the reaction surface of calcium-aluminate particles during leaching and immobilization of aluminum in CaTiO3(s) are also suggested to play important roles in limiting the aluminum leachability. Costs related to post-processing may be reduced by achieving disintegrating slags, a behavior which is observed for slags holding high γ- to β-Ca2SiO4 ratios. The disintegration is caused by the large volume expansion associated with the β-to-γ transformation and as such, various factors that are known to stabilize the β-polymorph are discussed.

Graphical Abstract
Lab-in-the-field experiments: perspectives from research on gender
Authors: Gangadharan Lata , Jain Tarun , Maitra Pushkar , Vecci Joe
Published: August 2021

This paper highlights the contributions made by lab-in-the-field experiments, which are also known as artefactual, framed and extra-lab experiments. We present a curated sample of lab-in-the-field experiments and discuss how they can be conducted on their own or combined with conventional laboratory experiments, natural experiments, randomised control trials and surveys to provide unique insights into the behaviour of a diverse population. Using our recent research on gender and leadership, we demonstrate how lab-in-the-field experiments have offered new perspectives about gender differences in decision-making. Finally, we outline the ethical and implementational challenges researchers may face while conducting these experiments and share some of the strategies we employed to address them.
Sustainability of renewable energy investment motivations during a feed-in-tariff scheme transition: evidence from a laboratory experiment
Authors: Maekawa Jun , Shimada Koji , Takeuchi Ai
Published: August 2021

This study analyzes the effects of a feed-in-tariff (FIT) scheme’s transition on renewable energy investments. We model an individual’s investment decisions as a public goods game where the FIT scheme’s purchasing price acts as a subsidy that lowers the individual’s investment cost. Using a laboratory experiment, we study the effects of a decreasing purchasing price by comparing it to a counterfactual situation where the FIT scheme is not introduced. Although a high purchasing price induces higher investments, this external incentive seems to crowd out an individual’s intrinsic motivation: when the purchasing price decreases to zero, an individual’s investments are lower than they are in the counterfactual situation. Considering the possibility that motivation crowding out has occurred during the FIT phase-out process, it is important to introduce a new policy instrument without a break to stimulate renewable energy investments.
How Sensitive Is the Neophallus? Postphalloplasty Experienced and Objective Sensitivity in Transmasculine Persons
Authors: Elfering Lian , van de Grift Tim C. , Al-Tamimi Muhammed , Timmermans Floyd W. , de Haseth Kristin B. , Pigot Garry L.S. , Lissenberg-Witte Birgit I. , Bouman Mark-Bram , Mullender Margriet G.
Published: August 2021

Introduction

Tactile and erogenous sensitivity of the neophallus after phalloplasty is assumed to affect the sexual well-being of transmasculine persons and, ultimately, their quality of life. The experienced and objective sensation of the neophallus and their association are largely unknown.

Aim

This study evaluated experienced tactile and erotic sensation of the neophallus in transmasculine persons and investigated how this was related to objective tactile sensitivity.

Methods

Between August 2017 and January 2020, 59 transmasculine persons who underwent phalloplasty were recruited to participate in a prospective follow-up study. Tactile sensitivity of the neophallus and donor-site was measured (Semmes-Weinstein Monofilament test) and compared, and participants were asked to fill out a questionnaire about experienced sensation of the neophallus and sexual wellbeing.

Main outcome measures

Experienced and objective sensation of the neophallus were measured by using a questionnaire and Semmes-Weinstein Monofilament scores.

Results

Neophallic tactile sensitivity was significantly reduced compared to the donor-site (n = 44), with the proximal part being more sensitive than the distal part (median follow-up of 1.8 years, range 1.0–7.2)). Sensitivity of the neophallus was not significantly associated with the surgical flap used, yet increased significantly with follow-up time. The questionnaire was completed by 26 participants of which 24 (92.3%) experienced (some degree of) tactile sensitivity in their neophallus. Erogenous sensation was experienced by 23 (88.5%). Experienced and objectified tactile sensitivity were not significantly correlated (Spearmans's rho = 0.23, P = .26). Answers to open-ended questions showed that results often do not match expectations.

Conclusion

Tactile sensation of the neophallus was reduced in most transmasculine persons and improved slowly over time. A significant association between subjective and objective measures could not be detected. Although experienced sensitivity varied between individuals, the vast majority reported to have tactile and erotic sensitivity in the neophallus.Transmasculine persons should be informed that sensitivity of the neophallus will likely be reduced.
Natural Law Theory
Authors: Angier Tom
Published: August 2021

In Section 1, I outline the history of natural law theory, covering Plato, Aristotle, the Stoics and Aquinas. In Section 2, I explore two alternative traditions of natural law, and explain why these constitute rivals to the Aristotelian tradition. In Section 3, I go on to elaborate a via negativa along which natural law norms can be discovered. On this basis, I unpack what I call three 'experiments in being', each of which illustrates the cogency of this method. In Section 4, I investigate and rebut two seminal challenges to natural law methodology, namely, the fact/value distinction in metaethics and Darwinian evolutionary biology. In Section 5, I then outline and criticise the 'new' natural law theory, which is an attempt to revise natural law thought in light of the two challenges above. I conclude, in Section 6, with a summary and some reflections on the prospects for natural law theory.
Inflammatory Biomarkers and Intracranial Hemorrhage after Endovascular Thrombectomy
Authors: Diestro Jose Danilo Bengzon , Parra-Farinas Carmen , Balas Michael , Zador Zsolt , Almusalam Noora , Dmytriw Adam A. , Rajendram Phavalan , Phillips Rebecca , Alqabbani Abdullah , Qazi Emmad , Li Yangmei , Montanera Walter , Sarma Dipanka , Marotta Thomas R. , Bharatha Aditya , Spears Julian
Published: August 2021

Background:

Intracranial hemorrhage after endovascular thrombectomy is associated with poorer prognosis compared with those who do not develop the complication. Our study aims to determine predictors of post-EVT hemorrhage – more specifically, inflammatory biomarkers present in baseline serology.

Methods:

We performed a retrospective review of consecutive patients treated with EVT for acute large vessel ischemic stroke. The primary outcome of the study is the presence of ICH on the post-EVT scan. We used four definitions: the SITS-MOST criteria, the NINDS criteria, asymptomatic hemorrhage, and overall hemorrhage. We identified nonredundant predictors of outcome using backward elimination based on Akaike Information Criteria. We then assessed prediction accuracy using area under the receiver operating curve. Then we implemented variable importance ranking from logistic regression models using the drop in Naegelkerke R2 with the exclusion of each predictor.

Results:

Our study demonstrates a 6.3% SITS (16/252) and 10.0% NINDS (25/252) sICH rate, as well as a 19.4% asymptomatic (49/252) and 29.4% (74/252) overall hemorrhage rate. Serologic markers that demonstrated association with post-EVT hemorrhage were: low lymphocyte count (SITS), high neutrophil count (NINDS, overall hemorrhage), low platelet to lymphocyte ratio (NINDS), and low total WBC (NINDS, asymptomatic hemorrhage).

Conclusion:

Higher neutrophil counts, low WBC counts, low lymphocyte counts, and low platelet to lymphoycyte ratio were baseline serology biomarkers that were associated with post-EVT hemorrhage. Our findings, particularly the association of diabetes mellitus and high neutrophil, support experimental data on the role of thromboinflammation in hemorrhagic transformation of large vessel occlusions.
Five-Year Psychosocial Impact of Living in Postdisaster Prefabricated Temporary Housing
Authors: Akaishi Tetsuya , Suzuki Tomomi , Nemoto Harumi , Utsumi Yusuke , Seto Moe , Usukura Hitomi , Kunii Yasuto , Sugawara Yumi , Nakaya Naoki , Nakamura Tomohiro , Tsuchiya Naho , Narita Akira , Kogure Mana , Hozawa Atsushi , Tsuji Ichiro , Ishii Tadashi , Tomita Hiroaki
Published: August 2021

Objective:

This study aims to evaluate the long-term impact of living in postdisaster prefabricated temporary housing on social interaction activities and mental health status.

Methods:

A total of 917 adult residents in a coastal town, whose residences were destroyed by the tsunami caused by the Great East Japan Earthquake (GEJE), were enrolled for the assessment held 5 y after the disaster. They answered questions about their experience and consequence of living in prefabricated temporary housing after the disaster. Their present scores on 5 types of self-reported measures regarding the psychosocial or psychiatric status and their present and recalled social interaction activities were cross-sectionally collected.

Results:

A total of 587 (64.0%) participants had a history of living in prefabricated temporary housing, while the other 330 (36.0%) had not. The prevalence of social interaction activities significantly decreased after the GEJE. However, the experience of living in prefabricated temporary housing did not adversely affect the subsequent social interaction activities or mental conditions of the participants 5 y after the disaster.

Conclusions:

Living in postdisaster prefabricated temporary housing may not negatively impact subsequent psychosocial conditions or social interaction activities 5 y later.
Unexpected details regarding nosocomial transmission revealed by whole-genome sequencing of severe acute respiratory coronavirus virus 2 (SARS-CoV-2)
Authors: Myhrman Sofia , Olausson Josefin , Ringlander Johan , Gustavsson Linéa , Jakobsson Hedvig E. , Sansone Martina , Westin Johan
Published: August 2021

Objective:

Effective infection prevention and control (IPC) measures are key for protecting patients from nosocomial infections and require knowledge of transmission mechanisms in different settings. We performed a detailed outbreak analysis of the transmission and outcome of coronavirus disease 2019 (COVID-19) in a geriatric ward by combining whole-genome sequencing (WGS) with epidemiological data.

Design:

Retrospective cohort study.

Setting:

Tertiary-care hospital.

Participants:

Patients and healthcare workers (HCWs) from the ward with a nasopharyngeal sample (NPS) positive for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) RNA during the outbreak period.

Methods:

Patient data regarding clinical characteristics, exposure and outcome were collected retrospectively from medical records. Stored NPSs from 32 patients and 15 HCWs were selected for WGS and phylogenetic analysis.

Results:

The median patient age was 84 years and 17 (53%) of 32 were male. Also, 14 patients (44%) died within 30 days of sampling. Viral loads were significantly higher among the deceased. WGS was successful in 28 (88%) of 32 patient samples and 14 (93%) of 15 HCW samples. Moreover, 3 separate viral clades were identified: 1 clade and 2 subclades among both patient and HCW samples. Integrated epidemiological and genetic analyses revealed 6 probable transmission events between patients and supported hospital-acquired COVID-19 among 25 of 32 patients.

Conclusions:

WGS provided an insight into the outbreak dynamics and true extent of nosocomial COVID-19. The extensive transmission between patients and HCWs indicated that current IPC measures were insufficient. We recommend increased use of WGS in outbreak investigations to identify otherwise unknown transmission links and to evaluate IPC measures.
Respiratory protection for health professions students must be addressed in light of lessons from the coronavirus disease 2019 (COVID-19) pandemic
Authors: Beam Elizabeth L.
Published: August 2021

One of the challenges the COVID-19 pandemic put before health professions programs in the United States was how to keep students clinically in patient care. With years of impact from coronavirus and growing numbers of variants, a long-term solution to respiratory protection for health professions students is needed.
Estimates of fluid intake, urine output and hydration-levels in women from Somaliland: a cross-sectional study
Authors: Heen Espen , Yassin Amal A. , Madar Ahmed A. , Romøren Maria
Published: August 2021

The study objective was to measure fluid intake and associations with background characteristics and hydration biomarkers in healthy, free-living, non-pregnant women aged 15–69 years from Hargeisa city. We also wanted to estimate the proportion of euhydrated participants and corresponding biomarker cut-off values. Data from 136 women, collected through diaries and questionnaires, 24h urine samples and anthropometric measurements, were obtained with a cross-sectional, purposeful sampling from fifty-two school and health clusters, representing approximately 2250 women. The mean (95 % CI) 24 h total fluid intake (TFI) for all women was 2⋅04 (1⋅88, 2⋅20) litres. In multivariate regression with weight, age, parity and a chronic health problem, only weight remained a predictor (P 0.034, B 0.0156 (l/kg)). Pure water, Somali tea and juice from powder and syrup represented 49⋅3, 24⋅6 and 11⋅7 % of TFI throughout the year, respectively. Mean (95 % CI) 24 h urine volume (Uvol) was 1⋅28 (1⋅17, 1⋅39) litres. TFI correlated strongly with 24 h urine units (r 0.67) and Uvol (r 0.59). Approximately 40 % of the women showed inadequate hydration, using a threshold of urine specific gravity (Usg) of 1⋅013 and urine colour (Ucol) of 4. Five percent had Usg > 1⋅020 and concomitant Ucol > 6, indicating dehydration. TFI lower cut-offs for euhydrated, non-breast-feeding women were 1⋅77 litres and for breast-feeding, 2⋅13 litres. Euhydration cut-off for Uvol was 0⋅95 litre, equalling 9⋅2 urine units. With the knowledge of adverse health effects of habitual hypohydration, Somaliland women should be encouraged to a higher fluid intake.
Mechanisms of meaning making in the co-occurrence of pragmatic markers with silent pauses
Authors: Schleef Erik
Published: August 2021

This study explores the social meanings of unfilled pauses, you know, like, and combinations thereof by comparing the evaluation of speech with these features to speech without them. The comparison is based on a set of perception surveys in which participants listened to manipulated audio stimuli and rated them on a series of scales. Unfilled pauses are evaluated differently from all other features: they are rated high on Status and low on Dynamism. Where significant differences emerge, the pragmatic markers you know, like, and combinations of pauses with these are always rated lower than the guises without. They are most sensitive to personal characteristics in the Dynamism dimension, followed by Conversational Skills, Likeability, and Status. The mechanism that adapts the potential social meanings of linguistic features when they are combined hinges on the social salience of the features in question. Various outcomes are possible ranging from additive to non-additive effects. (Like, you know, attitudes, social meanings, prestige, solidarity, dynamism)
Allostasis and metastasis: The yin and yang of childhood self-regulation
Authors: Wass Samuel V.
Published: August 2021

Most research has studied self-regulation by presenting experimenter-controlled test stimuli and measuring change between baseline and stimulus. In the real world, however, stressors do not flash on and off in a predetermined sequence, and there is no experimenter controlling things. Rather, the real world is continuous and stressful events can occur through self-sustaining interactive chain reactions. Self-regulation is an active process through which we adaptively select which aspects of the social environment we attend to from one moment to the next. Here, we describe this dynamic interactive process by contrasting two mechanisms that underpin it: the “yin” and “yang” of self-regulation. The first mechanism is allostasis, the dynamical principle underlying self-regulation, through which we compensate for change to maintain homeostasis. This involves upregulating in some situations and downregulating in others. The second mechanism is metastasis, the dynamical principle underling dysregulation. Through metastasis, small initial perturbations can become progressively amplified over time. We contrast these processes at the individual level (i.e., examining moment-to-moment change in one child, considered independently) and also at the inter-personal level (i.e., examining change across a dyad, such as a parent–child dyad). Finally, we discuss practical implications of this approach in improving the self-regulation of emotion and cognition, in typical development and psychopathology.
The Socialist Countries, North Africa and the Middle East in the Cold War: The Educational Connection
Authors: Katsakioris Constantin
Published: August 2021

This article revisits the Eastern Bloc's educational assistance provided to North Africa and the Middle East during the Cold War. It highlights the political and economic premises, interests and policies at play, and investigates the role of the Council for Mutual Economic Assistance. It examines the creation of schools in North Africa and the Middle East and the training of students in the socialist countries. The article argues for the centrality of education in the international policy of the Eastern Bloc, further demonstrating its importance in the political economy of the relations with the countries of North Africa and the Middle East.
State-led Development: The Privileged Linkage between East Germany and Ba'athist Syria, 1965–1972
Authors: Trentin Massimiliano
Published: August 2021

Upon request from the newly established Ba'athist leadership in Syria, the German Democratic Republic sent dozens of special advisors to Damascus between 1965 and 1972 to help set up the state institutions that would move Syria from being a predominantly agricultural country to an agro-industrial one: reforming the decision-making process of national government in Damascus, setting up central planning over production and distribution and enforcing land reform were some of the key issues dealt with by East German and Syrian officials. The encounter proved highly important because the two regimes came close enough to assess their mutual assets and limits upon which they would establish a long-lasting partnership, whose institutional legacy featured in Syrian formal politics as late as the 2000s. State institutions, mass organisations and public enterprises thus became the main avenues for these two ‘Easts’ to interact during the Cold War.
Resistance, Mastery, Agency: Improvising with the feedback-actuated augmented bass
Authors: Melbye Adam Pultz
Published: August 2021

In this article I describe the development of a performance practice with a new electroacoustic instrument – the FAAB (feedback-actuated augmented bass). Drawing on a background in improvisation, I discuss how the feedback-induced behaviour of the instrument sets it apart from an acoustic bass and how the implementation of operationally closed digital signal processing algorithms facilitates greater systemic autonomy. In identifying resistance as a key feature of improvisation, I propose the term ‘diachronic mastery’ as a way of addressing the equilibration of sensorimotor schemes in the context of developing a performance practice with a complex hybrid system such as the FAAB. Through a discussion of the term ‘agency’ as it appears in recent literature, I develop a preliminary framework for addressing both the immediate experience of agency emerging in performance ecosystems and the biologically informed definition of the term that may be useful in the design of increasingly autonomous instruments and performance systems.
Flows of Inhomogeneous Matter: Improvising an augmented violin
Authors: Thorn Seth Dominicus
Published: August 2021

This article reflects on how personal digital musical instruments evolve and presents an augmented violin developed and performed by the author in improvised performance as an example. Informed by the materialism of Gilles Deleuze and Felix Guattari, an image of ‘flows of inhomogeneous matter’ provokes reflection on a mode of production common to artisanal craftmanship and digital lutherie alike, namely the pre-reflective skilfulness negotiating the singularities of inhomogeneous matter with the demands of the production – a process which itself may be thought of asim-pro-visation(‘un-fore-seen’). According to Gilbert Simondon, all technical objects develop in this way: functional interdependency emerges when abstractly ideated elements begin to enter into unanticipated synergistic relationships, suggesting a material logic dependent on unforeseen potentialities. The historical development of the acoustic violin exemplifies such an evolution, with, like all technical objects, additional latent potential. Digital artists can work like artisanal craftsmen in tinkering with technical elements, teasing out their synergies through abductive, trial-and-error experimentation. In the context of developing digital musical instruments, model-free design of real-time digital signal processing symmetrising action and perception yields highly refined results. Like musical improvisation – constrained by time – improvised development of these instruments turns the material obstacles into their very means of realisation.
Soil Fertility Transitions in the Context of Industrialization, 1750–2000
Authors: Güldner Dino , Larsen Laura , Cunfer Geoff
Published: August 2021

Fertile soils are essential for human health and nutrition and formed the foundation of human economies for millennia. Soils deserve close attention from environmental and economic historians and sustainability scientists. Most soil history literature addresses failure: misuse of soil, uncontrolled erosion, and the resulting collapse of past civilizations. More important, however, and of urgent interest for our present and future prosperity, are the mundane ways that historical farm communities sustained soil health, even while cultivating the same land for centuries. This article explains five strategies by which European and North American farmers accessed, recycled, replenished, and sustained soil fertility over 250 years. By evaluating inputs, extractions, transfers, and annual balances of potassium, phosphorus, and, especially, nitrogen, it models historical soil management in a variety of agroecosystems in various geographical settings and through time. This biophysical environmental history, based on socioecological metabolism methods borrowed from sustainability science, reveals ongoing adaptation to shifting social and environmental contexts. As industrialization, global trade, and population accelerated, farmers adjusted their soil fertility strategies to keep up with new pressures and opportunities. Each solution to existing soil fertility constraints created new obstacles and bottlenecks. Through the past quarter millennium, farm sustainability meant constant readjustment to new circumstances. As farmers innovated crop choices and rotations, corralled livestock, adopted new technologies, deployed novel energy sources, and expanded into new lands, they increased food productivity to feed growing world population and supply expanding markets, while maintaining the supply of soil nutrients necessary to fertilize next year’s crop.
On the Emergence of Human Influence on Surface Air Temperature Changes Over India
Authors: Dileepkumar R. , AchutaRao Krishna , J. W. Bonfils Céline , Arulalan T.
Published: August 2021

Human activities in terms of greenhouse gas (GHG) emissions and aerosols resulting from the combustion of fossil fuels have been shown to have affected the temperature of the Earth on global and continental scales. The surface air temperature (TAS) over India has also been observed to be increasing over the last 100 years. Understanding the underlying causes of regional climate change over India can help in developing appropriate mitigation and adaptation strategies. Differentiating signals of externally forced climate changes from the noise of natural internal variability generally becomes more difficult as spatial scale reduces. Therefore detecting and attributing the influence of external forcings such as GHGs and aerosols is harder at local and regional scales. In this study, we applied a detection and attribution (D&A) method to study annual and seasonal mean TAS over the Indian region. We found that the observed warming over India from 1906 to 2005 cannot be explained by natural climate variability alone. We found that the warming is largely driven by the increase in GHGs, and partially offset by regional anthropogenic emissions of aerosols. These results were confirmed for the shorter 1956–2005 period, but results were sensitive to the choice of observational data set. The changes cannot be explained by internal climate variability or natural external forcings alone, but are compatible with the responses to combined anthropogenic GHG and aerosol forcings.
Negligible Quantities of Particulate Low‐Temperature Pyrogenic Carbon Reach the Atlantic Ocean via the Amazon River
Authors: Häggi C. , Hopmans E. C. , Schefuß E. , Sawakuchi A. O. , Schreuder L. T. , Bertassoli D. J. , Chiessi C. M. , Mulitza S. , Sawakuchi H. O. , Baker P. A. , Schouten S.
Published: August 2021

Particulate pyrogenic carbon (PyC) transported by rivers and aerosols, and deposited in marine sediments, is an important part of the carbon cycle. The chemical composition of PyC is temperature dependent and levoglucosan is a source‐specific burning marker used to trace low‐temperature PyC. Levoglucosan associated to particulate material has been shown to be preserved during riverine transport and marine deposition in high‐ and mid‐latitudes, but it is yet unknown if this is also the case for (sub)tropical areas, where 90% of global PyC is produced. Here, we investigate transport and deposition of levoglucosan in suspended and riverbed sediments from the Amazon River system and adjacent marine deposition areas. We show that the Amazon River exports negligible amounts of levoglucosan and that concentrations in sediments from the main Amazon tributaries are not related to long‐term mean catchment‐wide fire activity. Levoglucosan concentrations in marine sediments offshore the Amazon Estuary are positively correlated to total organic content regardless of terrestrial or marine origin, supporting the notion that association of suspended or dissolved PyC to biogenic particles is critical in the preservation of PyC. We estimate that 0.5–10 × 106 g yr−1 of levoglucosan is exported by the Amazon River. This represents only 0.5–10 ppm of the total exported PyC and thereby an insignificant fraction, indicating that riverine derived levoglucosan and low‐temperature PyC in the tropics are almost completely degraded before deposition. Hence, we suggest caution in using levoglucosan as tracer for past fire activity in tropical settings near rivers.
Long‐Term Nitrate Trajectories Vary by Season in Western European Catchments
Authors: Ebeling Pia , Dupas Rémi , Abbott Benjamin , Kumar Rohini , Ehrhardt Sophie , Fleckenstein Jan H. , Musolff Andreas
Published: August 2021

Human alteration of nutrient cycles has caused persistent and widespread degradation of water quality around the globe. In many regions, including Western Europe, elevated nitrate (NO3−) concentration in surface waters contributes to eutrophication and noncompliance with environmental legislation. Discharge, NO3− concentrations and the vulnerability of the aquatic ecosystems to eutrophication often exhibit a distinct seasonality. Understanding spatial patterns and long‐term trends in this seasonality is crucial to improve water quality management. Here, we hypothesized that NO3− concentrations during high‐flow periods would respond faster to changes in nutrient inputs than low‐flow concentrations because of greater connectivity of shallow diffuse NO3− sources with the river network. To test this hypothesis, we compiled long‐term NO3− and discharge time series from 290 Western European catchments. To characterize the long‐term trajectories of seasonal NO3− concentration, we propose a novel hysteresis approach comparing low‐ and high‐flow NO3− concentration in the context of multi‐decadal N input changes. We found synchronous winter maxima of NO3− and discharge in 84% of the study catchments. However, contrary to our hypothesis, there were surprisingly diverse long‐term trajectories of seasonal NO3− concentration. Both clockwise (faster high‐flow NO3− response) and counterclockwise hysteresis (faster low‐flow NO3− response) occurred in similar proportions, potentially due to a high complexity in the underlying processes. Spatial variability of seasonality in NO3− concentration across the catchments was more pronounced and better predictable than its long‐term variability. This work demonstrates the value of seasonal and inter‐annual hydrochemical analysis and provides new tools for water quality monitoring and management.
Thermal Conductivity of Silicate Liquid Determined by Machine Learning Potentials
Authors: Deng Jie , Stixrude Lars
Published: August 2021

Silicate liquids are important agents of thermal evolution, yet their thermal conductivity is largely unknown. Here, we determine the thermal conductivity of a silicate liquid by combining the Green‐Kubo method with a machine learning potential of ab initio quality over the entire pressure regime of the mantle. We find that the thermal conductivity of MgSiO3 liquid is 1.1 W m−1 K−1 at the 1 bar melting point, and 4.0 W m−1 K−1 at core‐mantle boundary conditions. The thermal conductivity increases with compression, while remaining nearly constant on isochoric heating. The pressure dependence arises from the increasing bulk modulus on compression, and the weak temperature dependence arises from the saturation of the phonon mean free path due to structural disorder. The thermal conductivity of silicate liquids is less than that of ambient mantle, a contrast that may be important for understanding melt generation, and heat flux from the core.
Shallow Rupture Propagation of Pleistocene Earthquakes Along the Hurricane Fault, UT, Revealed by Hematite (U‐Th)/He Thermochronometry and Textures
Authors: Taylor Madison P. , Ault Alexis K. , Odlum Margaret L. , Newell Dennis L.
Published: August 2021

The material properties and distribution of faults above the seismogenic zone promote or inhibit earthquake rupture propagation. We document the depths and mechanics of fault slip along the seismically active Hurricane fault, UT, with scanning and transmission electron microscopy and hematite (U‐Th)/He thermochronometry. Hematite occurs as mm‐scale, striated patches on a >10 m2 thin, mirror‐like silica fault surface. Hematite textures include bulbous aggregates and cataclasite, overlain by crystalline Fe‐oxide nanorods and an amorphous silica layer at the slip interface. Textures reflect mechanical, fluid, and heat‐assisted amorphization of hematite and silica‐rich host rock that weaken the fault and promote rupture propagation. Hematite (U‐Th)/He dates document episodes of mineralization and fault slip between 0.65 and 0.36 Ma at ∼300 m depth. Data illustrate that some earthquake ruptures repeatedly propagate along localized slip surfaces in the shallow crust and provide structural and material property constraints for in models of fault slip.
Emotional adaptation during a crisis: decline in anxiety and depression after the initial weeks of COVID-19 in the United States
Authors: Shuster Anastasia , O’Brien Madeline , Luo Yi , Berner Laura A. , Perl Ofer , Heflin Matthew , Kulkarni Kaustubh , Chung Dongil , Na Soojung , Fiore Vincenzo G. , Gu Xiaosi
Published: August 2021

Crises such as the COVID-19 pandemic are known to exacerbate depression and anxiety, though their temporal trajectories remain under-investigated. The present study aims to investigate fluctuations in depression and anxiety using the COVID-19 pandemic as a model crisis. A total of 1512 adults living in the United States enrolled in this online study beginning April 2, 2020 and were assessed weekly for 10 weeks (until June 4, 2020). We measured depression and anxiety using the Zung Self-Rating Depression scale and State-Trait Anxiety Inventory (state subscale), respectively, along with demographic and COVID-related surveys. Linear mixed-effects models were used to examine factors contributing to longitudinal changes in depression and anxiety. We found that depression and anxiety levels were high in early April, but declined over time. Being female, younger age, lower-income, and previous psychiatric diagnosis correlated with higher overall levels of anxiety and depression; being married additionally correlated with lower overall levels of depression, but not anxiety. Importantly, worsening of COVID-related economic impact and increase in projected pandemic duration exacerbated both depression and anxiety over time. Finally, increasing levels of informedness correlated with decreasing levels of depression, while increased COVID-19 severity (i.e., 7-day change in cases) and social media use were positively associated with anxiety over time. These findings not only provide evidence for overall emotional adaptation during the initial weeks of the pandemic, but also provide insight into overlapping, yet distinct, factors contributing to depression and anxiety throughout the first wave of the pandemic.
Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia
Authors: Zahova Simona K. , Humby Trevor , Davies Jennifer R. , Morgan Joanne E. , Isles Anthony R.
Published: August 2021

Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder caused by mutations affecting paternal chromosome 15q11-q13, and characterized by hypotonia, hyperphagia, impaired cognition, and behavioural problems. Psychotic illness is a challenging problem for individuals with PWS and has different rates of prevalence in distinct PWS genotypes. Previously, we demonstrated behavioural and cognitive endophenotypes of relevance to psychiatric illness in a mouse model for one of the associated PWS genotypes, namely PWS-IC, in which deletion of the imprinting centre leads to loss of paternally imprinted gene expression and over-expression of Ube3a. Here we examine the broader gene expression changes that are specific to the psychiatric endophenotypes seen in this model. To do this we compared the brain transcriptomic profile of the PWS-IC mouse to the PWS-cr model that carries a deletion of the PWS minimal critical interval spanning the snoRNA Snord116 and Ipw. Firstly, we examined the same behavioural and cognitive endophenotypes of relevance to psychiatric illness in the PWS-cr mice. Unlike the PWS-IC mice, PWS-cr exhibit no differences in locomotor activity, sensory-motor gating, and attention. RNA-seq analysis of neonatal whole brain tissue revealed a greater number of transcriptional changes between PWS-IC and wild-type littermates than between PWS-cr and wild-type littermates. Moreover, the differentially expressed genes in the PWS-IC brain were enriched for GWAS variants of episodes of psychotic illness but, interestingly, not schizophrenia. These data illustrate the molecular pathways that may underpin psychotic illness in PWS and have implications for potential therapeutic interventions.
Obinutuzumab-atezolizumab-lenalidomide for the treatment of patients with relapsed/refractory follicular lymphoma: final analysis of a Phase Ib/II trial
Authors: Morschhauser Franck , Ghosh Nilanjan , Lossos Izidore S. , Palomba M. Lia , Mehta Amitkumar , Casasnovas Olivier , Stevens Don , Katakam Sudhakar , Knapp Andrea , Nielsen Tina , McCord Ron , Salles Gilles
Published: August 2021

We evaluated the triplet regimen obinutuzumab-atezolizumab-lenalidomide (G-atezo-len) for patients with relapsed/refractory (R/R) follicular lymphoma (FL) in an open-label, multicenter phase Ib/II study (BO29562; NCT02631577). An initial 3 + 3 dose‐escalation phase to define the recommended phase II dose of lenalidomide was followed by an expansion phase with G-atezo-len induction and maintenance. At final analysis, 38 patients (lenalidomide 15 mg, n = 4; 20 mg, n = 34) had completed the trial. Complete response rate for the efficacy population (lenalidomide 20 mg, n = 32) at end-of-induction was 71.9% (66.7% in double‐refractory patients [refractory to rituximab and alkylator] [n = 12]; 50.0% in patients with progressive disease within 24 months of first-line therapy [n = 12]). The 36-month progression-free survival rate was 68.4%. All treated patients had ≥1 adverse event (AE; grade 3–5 AE, 32 patients [84%]; serious AE, 18 patients [47%]; AEs leading to discontinuation of any study drug, 11 patients [29%]). There were 2 fatal AEs (1 merkel carcinoma, 1 sarcomatoid carcinoma; both unrelated to any study drug). The G‐atezo-len regimen is effective and tolerable in patients with R/R FL. AEs were consistent with the known safety profile of the individual drugs.
Spin–orbit torque engineering in β-W/CoFeB heterostructures with W–Ta or W–V alloy layers between β-W and CoFeB
Authors: Kim Gyu Won , Cuong Do Duc , Kim Yong Jin , Cha In Ho , Kim Taehyun , Lee Min Hyeok , Lee OukJae , Baik Hionsuck , Hong Soon Cheol , Rhim Sonny H. , Kim Young Keun
Published: August 2021

The spin–orbit torque (SOT) resulting from a spin current generated in a nonmagnetic transition metal layer offers a promising magnetization switching mechanism for spintronic devices. To fully exploit this mechanism, in practice, materials with high SOT efficiencies are indispensable. Moreover, new materials need to be compatible with semiconductor processing. This study introduces W–Ta and W–V alloy layers between nonmagnetic β-W and ferromagnetic CoFeB layers in β-W/CoFeB/MgO/Ta heterostructures. We carry out first-principles band structure calculations for W–Ta and W–V alloy structures to estimate the spin Hall conductivity. While the predicted spin Hall conductivity values of W–Ta alloys decrease monotonically from −0.82 × 103 S/cm for W100 at% as the Ta concentration increases, those of W–V alloys increase to −1.98 × 103 S/cm for W75V25 at% and then gradually decrease. Subsequently, we measure the spin Hall conductivities of both alloys. Experimentally, when β-W is alloyed with 20 at% V, the absolute value of the spin Hall conductivity considerably increases by 36% compared to that of the pristine β-W. We confirm that the W–V alloy also improves the SOT switching efficiency by approximately 40% compared to that of pristine β-W. This study demonstrates a new material that can act as a spin current-generating layer, leading to energy-efficient spintronic devices.
UbiD domain dynamics underpins aromatic decarboxylation
Authors: Marshall Stephen A. , Payne Karl A. P. , Fisher Karl , Titchiner Gabriel R. , Levy Colin , Hay Sam , Leys David
Published: August 2021

The widespread UbiD enzyme family utilises the prFMN cofactor to achieve reversible decarboxylation of acrylic and (hetero)aromatic compounds. The reaction with acrylic compounds based on reversible 1,3-dipolar cycloaddition between substrate and prFMN occurs within the confines of the active site. In contrast, during aromatic acid decarboxylation, substantial rearrangement of the substrate aromatic moiety associated with covalent catalysis presents a molecular dynamic challenge. Here we determine the crystal structures of the multi-subunit vanillic acid decarboxylase VdcCD. We demonstrate that the small VdcD subunit acts as an allosteric activator of the UbiD-like VdcC. Comparison of distinct VdcCD structures reveals domain motion of the prFMN-binding domain directly affects active site architecture. Docking of substrate and prFMN-adduct species reveals active site reorganisation coupled to domain motion supports rearrangement of the substrate aromatic moiety. Together with kinetic solvent viscosity effects, this establishes prFMN covalent catalysis of aromatic (de)carboxylation is afforded by UbiD dynamics.
Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
Authors: Diener Johanna , Baggiolini Arianna , Pernebrink Mattias , Dalcher Damian , Lerra Luigi , Cheng Phil F. , Varum Sandra , Häusel Jessica , Stierli Salome , Treier Mathias , Studer Lorenz , Basler Konrad , Levesque Mitchell P. , Dummer Reinhard , Santoro Raffaella , Cantù Claudio , Sommer Lukas
Published: August 2021

Melanoma cells rely on developmental programs during tumor initiation and progression. Here we show that the embryonic stem cell (ESC) factor Sall4 is re-expressed in the Tyr::NrasQ61K; Cdkn2a−/− melanoma model and that its expression is necessary for primary melanoma formation. Surprisingly, while Sall4 loss prevents tumor formation, it promotes micrometastases to distant organs in this melanoma-prone mouse model. Transcriptional profiling and in vitro assays using human melanoma cells demonstrate that SALL4 loss induces a phenotype switch and the acquisition of an invasive phenotype. We show that SALL4 negatively regulates invasiveness through interaction with the histone deacetylase (HDAC) 2 and direct co-binding to a set of invasiveness genes. Consequently, SALL4 knock down, as well as HDAC inhibition, promote the expression of an invasive signature, while inhibition of histone acetylation partially reverts the invasiveness program induced by SALL4 loss. Thus, SALL4 appears to regulate phenotype switching in melanoma through an HDAC2-mediated mechanism.
Ferromagnetic soft catheter robots for minimally invasive bioprinting
Authors: Zhou Cheng , Yang Youzhou , Wang Jiaxin , Wu Qingyang , Gu Zhuozhi , Zhou Yuting , Liu Xurui , Yang Yueying , Tang Hanchuan , Ling Qing , Wang Liu , Zang Jianfeng
Published: August 2021

In vivo bioprinting has recently emerged as a direct fabrication technique to create artificial tissues and medical devices on target sites within the body, enabling advanced clinical strategies. However, existing in vivo bioprinting methods are often limited to applications near the skin or require open surgery for printing on internal organs. Here, we report a ferromagnetic soft catheter robot (FSCR) system capable of in situ computer-controlled bioprinting in a minimally invasive manner based on magnetic actuation. The FSCR is designed by dispersing ferromagnetic particles in a fiber-reinforced polymer matrix. This design results in stable ink extrusion and allows for printing various materials with different rheological properties and functionalities. A superimposed magnetic field drives the FSCR to achieve digitally controlled printing with high accuracy. We demonstrate printing multiple patterns on planar surfaces, and considering the non-planar surface of natural organs, we then develop an in situ printing strategy for curved surfaces and demonstrate minimally invasive in vivo bioprinting of hydrogels in a rat model. Our catheter robot will permit intelligent and minimally invasive bio-fabrication.
Description of larval morphology and phylogenetic relationships of Heterotemna tenuicornis (Silphidae)
Authors: Mahlerová Karolina , Jakubec Pavel , Novák Martin , Růžička Jan
Published: August 2021

Providing clear and detailed morphological descriptions of endemic species in limited areas enables new knowledge of their biology and ecology to be obtained through citizen science. This information can be further used for their protection. Our study presents the first morphological description of the larvae of all three instars of Heterotemna tenuicornis (Brullé, 1836), an endemic species of the Canary Islands that, together with H. britoi García & Pérez, 1996 and H. figurata (Brullé, 1839), belongs to the peculiar genus Heterotemna Wollaston, 1864. Furthermore, we present the first sequences of two mitochondrial genes (COI, 16S) obtained from larval specimens, and cross reference them with sequences from an adult specimen. Phylogenetic analysis of molecular data placed the genus Heterotemna within the genus Silpha Linnaeus, 1758, suggesting paraphyly of Silpha. In our study, we underline the importance of using a combination of morphological description and molecular data, that can be used for barcoding developmental stages which could not otherwise be definitely associated.