bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review of the Justifications for Mandatory Vaccination Policies in Response to the COVID-19 Public Health Crisis
Authors: YOU Kihoon , KIM Ock-Joo
Published: July 2023

In response to the ongoing COVID-19 pandemic, several countries introduced mandatory vaccination policies to increase vaccination rates. These policies were controversial because they were seen, at least by some, as coercive measures that violated individual rights and freedoms. This article examines some of the arguments that were given, both for and against, the mandatory vaccination policies that certain countries implemented in response to the COVID-19 pandemic. The four arguments for vaccine mandates that are examined concern (1) the prevention of harm to others, (2) acceptable levels of risk, (3) collective obligations, and (4) fairness in achieving essential public goods. The three arguments against vaccine mandates that are addressed concern (1) remote harms, (2) the absence of additional benefits, (3) and individual autonomy and bodily integrity. On the basis of this analysis, the article attempts to determine which specific vaccine policies, among the many that were implemented or considered, are ethically justifiable.
USING COLLABORATIVE LEARNING TECHNIQUES STRATEGIES TO IMPROVE STUDENT’S COLLABORATIVE SKILLS IN SECONDARY SCHOOL
Authors: Basari Jupri
Published: July 2023

This study was conducted to identify the effectiveness of collaborative learning technique strategies to improve students' collaborative skills in terms of academic benefits, social benefits, generic skills and negative aspects of students. The study was conducted using a quasi-experimental method in two secondary schools in the district of Lahad Datu, Sabah and involved a total of 180 fourth form students taking the subject of Additional Mathematics. In each school, students were divided into two groups consisting of a control group that was taught using an unstructured group learning strategy and a treatment group that was taught using a collaborative learning technique strategy for three weeks. The instrument used is a questionnaire adapted from Brown (2008). The pre and post scores of the student groups were then analyzed using the Statistical Package for Social Science for Windows Version 26.0 (SPSS) software. SPSS software was used to obtain the mean of the overall score of the control and treatment groups in the pre-post score, the t-test value of the students' perception of the effectiveness of the collaborative learning technique strategy. The results of the data analysis done on the pre-post scores of the treatment and control groups found that there was an increase in collaborative skills in terms of academic benefits, social benefits, generic skills and negative aspects of students in the treatment group compared to the control group. This situation shows that the use of collaborative learning technique strategies in teaching and learning can help improve students' collaborative skills. The process of interaction that occurs through the strategy of collaborative learning techniques helps improve students' collaborative skills. This study provides important implications for identifying alternatives that teachers can use to improve students' collaborative skills.
Transformações espaciais e novos sistemas de engenharia no corredor de exportações rodofluvial BR-163 e rio Tapajós/Amazonas
Authors: Oliveira Neto Thiago
Published: July 2023

Este texto aborda as principais transformações espaciais no corredor de exportação constituído pela rodovia BR-163 e pelas novas rotas fluviais de transporte de grãos que foram organizadas pelo capital privado, a partir de 2013, nos rios Tapajós e Amazonas. As transformações espaciais aqui relatadas foram identificadas em três trabalhos de campo realizados em 2018, 2022 e em 2023.Esses trabalhos permitiram analisar o complexo arranjo espacial existente e a presença de grandes infraestruturas de transportes construídas na Amazônia, principalmente no município de Itaituba. Fazendo o uso de diversas figuras e mapas para fins de representar as grandes infraestruturas construídas na Amazônia, o texto privilegiou abordar o arranjo espacial do transporte de grãos, com enfoque no percurso rodofluvial composto pela rodovia BR-163, rio Tapajós e Amazonas, estes compõem um dos mais contraditórios corredores de transportes, que foi organizado e produzido para fins de atender as dinâmicas de circulação de grãos do estado do Mato Grosso ao mercado internacional. No decorrer do texto, destaca-se que vários lugares da calha do rio Amazonas estão articulados às dinâmicas de circulação da Santarém-Cuiabá, principalmente os portos fluviais de Itaituba-PA, Santarém-PA, Barcarena-PA e de Santana-AP.
A group of researchers are testing pseudopartitives in Italian: Notional number is not the key to the facts
Authors: Foppolo Francesca , Mazzaggio Greta , Franco Ludovico , Manzini Maria Rita
Published: July 2023

The present paper focuses on pseudopartitive constructions headed by quantifier, collective, or container nouns (like a lot of senators, a group of students, a bottle of pills) followed by a singular or a plural verb. We compared these structures with superficially similar adnominal structures of the form NP1[−PL] prep NP2[PL] (e.g., the level of the lakes is/are) in Italian in an acceptability judgment study (Experiment 1), a forced-choice task (Experiment 2), and an eye tracking reading study (Experiment 3). Two major findings were consistent across all studies. First, verb agreement in pseudopartitives always patterned differently from controls. Second, albeit an overall preference for singular verbs was observed, a gradient difference emerged between adnominal controls and pseudopartitives, and among pseudopartitives headed by different nouns. We explain such variability in terms of the availability of a measure interpretation (e.g., pills in the measure of a bottle vs. a bottle containing pills) which is linked to the type of the pseudopartitive’s head noun. While in non-pseudopartitive adnominal structures only one parse is allowed by the grammar, in pseudopartitives a given head noun may admit or block a structural configuration in which the plural feature of the embedded constituent (e.g., of students, modifying a group) can determine the plurality of the subsequent verb. We conclude that verb agreement in pseudopartitives is a grammatical phenomenon and, as such, it refers to speakers’ grammatical competence and cannot be reduced to agreement attraction of the plural intervener.
The MVA-CoV2-S vaccine developed at the CNB-CSIC is highly immunogenic and completely effective against SARS-CoV-2/COVID-19: future and opportunities
Authors: García-Arriaza Juan , Esteban Rodríguez Mariano
Published: July 2023

The appearance of a new emerging virus at the end of 2019, later identified as SARS-CoV-2, which rapidly spread to the human population causing the COVID-19 pandemic (with more than 639 million people infected and more than 6.6 million deaths by November 2022), was a great challenge for science, with serious consequences for the human health system and global economy. In record time, different types of vaccines were produced that demonstrated their safety and efficacy in clinical trials and whose administration to the population has been essential for curbing the pandemic, avoiding infections, hospitalizations and deaths. Our laboratory at the CNB-CSIC has been very active in this race, generating a vaccine candidate based on the poxvirus vector termed modified vaccinia virus Ankara (MVA), which demonstrated in three animal models (mouse, hamster and rhesus macaque) its high safety, robust immunogenicity and full efficacy against SARS-CoV-2 infection. This article describes the steps that we follow it up from the beginning of the pandemic to culminate in the industrial development of a very promising vaccine candidate. The next phase is clinical trials in humans. We also discuss about other vaccines, future and opportunities in the medium-long term.

Keywords: MVA; SARS-CoV-2/COVID-19: vaccine; immunogenicity; efficacy; animal models
Introduction to humanism and transhumanism
Authors: Sentandreu Ramón Rafael
Published: July 2023

This essay shows the differences between the philosophy of humanists and transhumanism. The first aims to give a comprehensive view of man seen from a rational and ethical point of view, highlighting his central position in the universe and its impact on other living beings and climate change.
Transhumanism focuses specifically on the optimization of Homo sapiens, and aims to perfect it through a technical-scientific program (development of cyborgs and genetic changes) leading to the birth of a new biological species more capable of adapting to the environment in which it finds itself.

Keywords: humanism; transhumanism; robot; bioethics
The availability of medicines in Spain
Authors: Esteve Salà Emili
Published: July 2023

In the European Union (EU) procedures for the authorization of medicinal products are applied to incorporate new medicinal products and their successive amendments under the same conditions in all Member States. However, the effective marketing of medicinal products differs, and the intended harmonization based on a single authorization valid for the whole EU is fragmented by the subsequent intervention of the Member States responsible for price and reimbursement.
The difference in the availability of medicines affects patients when the product is not effectively marketed. Spain was in an intermediate position in the EU, however, the latest published data indicate a clear deterioration in the availability of new medicines, moving it away from countries such as Germany, France or Italy.
On the other hand, apart from innovations, there is another group of medicines with availability problems. They are medicines considered essential in therapeutics and that have been marketed for years with a continuous erosion of their prices, reducing their marketing viability. The AEMPS has qualified in May 2022 as strategic medicines some of these medicines, essential from a therapeutic point of view and, at the same time, vulnerable in relation to their supply.
The intention of this paper is to revise the causes that most influence the availability of medicines in Spain and the changes that could favor their better access, both with respect to new medicines and strategic medicines.

Keywords: availability of medicine; access to medicines; strategic medicine; critical medicines
The Impact of Digital Marketing on Generation Z’s Decision to be Vaccinated Against COVID-19
Authors: PRODROMIADOU Ioanna , TZORTZI Athanasia , KATHARAKI Maria
Published: July 2023

Generation Z is the first generation that grew up exclusively with the use of the internet and digital media in their daily life, at a time when information sharing and reproduction happens at an unimaginable speed, from any- one to anyone. The purpose of this study is to investigate the role of digital marketing in informing Generation Z about COVID-19 vaccination and how this information affects their decision to be vaccinated. A quantitative cross-sectional study with a structured questionnaire was used. The questionnaire was distributed to 18-25 years old people. The sample consisted of 103 individuals belonging to Generation Z. The Cronbach’s alpha was found 0.85. Chi- square test of Independence and Cross-tabulation analysis were performed for the examination of statistical hypotheses. Multiple linear regression analysis was applied to examine the effect of demographics and the use of digital media on the vaccination decision. Statistical significance was set at 0.05. 69 women (67%), 33 men (32%), and 1 per- son (1%) who had not identified the sex participated in the study. The internet and social media were the most widespread sources of information for Generation Z regarding the COVID-19 pandemic and vaccination. The level of edu- cation (p=0.001) and professional activity (p=0.011) were statistically significant to Generation Z’s vaccination against COVID-19. Information from medical staff (p=0.002) and not from other sources, such as family/friends or the internet, was found statistically sig- nificant to vaccination. Regarding social media, Twitter was positively statistically significant (p=0.010) to the vaccination decision, as well as the presence of competent health Authorities on social media (p=0.044), which had a statistically significant positive effect on Generation Z vac- cination. The findings clearly indicate that the advantages of digital marketing, such as immediacy and low cost com- bined with the extensive use of the internet and social media by individuals belonging to Generation Z, can con- tribute to increasing COVID-19 vaccination coverage.
Empirical evaluation of the impact of throughput costing on the financial metrics of manufacturing firms in Nigeria
Authors: Monday Osirim , George Wadike Chile , Diepiriye Davies Stanley
Published: July 2023

The main purpose of the study was to empirically examine the relationship between throughput costing and financial metrics of manufacturing firms in Nigeria. Secondary data sourced from audited annual reports of Guinness Nigeria plc and International Breweries Plc for the period 2008-2019 was utilized for the study. The data collected was analysed using ordinary least regression analysis with the aid of SPSS. The result of the study reveal an insignificant relationship between throughput costing (INV, INSALEs) and financial metrics (NPM, ROI) of manufacturing firms in Nigeria. Based on this outcome, it was recommended that manufacturing firms in Nigeria should in addition to implementing the system of throughput costing in the management of resources, should carry out other managerial accounting techniques such as Just-in Time system, Activity Based Costing, Target costing and Kaizen costing system so as to increase their financial performance.
Estrategias del Servicio Geológico Colombiano en la búsqueda de la apropiación social del conocimiento geocientífico y la gestión del riesgo volcánico del Nevado del Ruiz
Authors: Cortés Jiménez Gloria Patricia , Castaño Vasco Leidy Johana
Published: July 2023

La Apropiación Social del Conocimiento Geocientífico (ASCG) es clave para una exitosa gestión del riesgo de desastres (GRD) en un territorio. En el caso de la vulcanología, el conocimiento científico debe ser conocido y utilizado por las comunidades en riesgo volcánico. Este artículo presenta las estrategias implementadas por el Servicio Geológico Colombiano (SGC) y su Observatorio Vulcanológico y Sismológico de Manizales (OVSMA) para promover la ASCG y la Gestión del Riesgo Volcánico (GRV) del volcán Nevado del Ruiz (VNR). Las estrategias se basan en las lecciones de la erupción del VNR en 1985, el segundo mayor desastre volcánico del siglo XX con 25,000 víctimas. Es fundamental que las personas en riesgo conozcan su territorio. La gestión del riesgo de este volcán, el más activo en Colombia, es un gran desafío. Hemos encontrado que estas estrategias fortalecen la institución, fomentan el diálogo con las comunidades, diversifican los espacios de encuentro, promueven la comunicación y educación, favorecen la coproducción de conocimiento y sensibilizan sobre la participación comunitaria y corresponsabilidad en la GRD. El artículo contextualiza la ASCG, la GRV en Colombia y el legado de la erupción, mientras reflexiona sobre las estrategias implementadas y sus aportes a la GRD.
Un Sol Interior: Vulcanología Lickanantay en el Salar de Atacama
Authors: Ramos Chocobar Sonia , Tironi Manuel
Published: July 2023

Habiendo vivido junto al dinamismo geológico de la cuenca del Salar de Atacama (Chile) por milenios, el pueblo Lickanantay ha acumulado abundantes datos observacionales y ceremoniales acerca de la naturaleza volcánica que les rodea y la participación de volcanes en procesos más amplios de formación cosmoecológica. Sin embargo, la vulcanológica formal no ha establecido un diálogo sustantivo con estos conocimientos. A través de una colaboración intercultural, este artículo expone lo que llamamos ‘vulcanología Lickanantay’ —o el sistema Lickanantay de conocimiento sobre volcanes, relaciones volcanes-humanos e interdependencia geocósmica— con el objetivo de hacerla disponible para la comunidad vulcanológica general. Primero, describimos las características básicas de la vulcanología Lickanantay. Luego nos enfocamos en el campo geotérmico de El Tatio para ofrecer una aproximación situada. Finalmente, delineamos algunos elementos para la gestión del riesgo volcánico desde una perspectiva Lickanantay. En nuestras conclusiones sugerimos que la vulcanología Lickanantay invita a pensar lo ‘indígena’ no como un conjunto finito de conocimientos y prácticas sino como una demanda por autonomía territorial y epistemológica, y que es sólo reconociendo esa demanda que la vulcanología podrá responder al llamado de la descolonización de la ciencia.
Análise das publicações científicas
Authors: Coutinho Gisele , Paes Irani Aparecida Dalla Costa
Published: July 2023

A Unidade de Terapia Intensiva Neonatal (UTIN) foi criada a partir de 1960 e, depois dessa nova perspectiva, houve um crescimento tecnológico e domínio do saber, favorecendo ao aumento da sobrevida de recém-nascido cada vez mais prematuro e de baixo peso; porém, cresceu também, a necessidade de formação de profissionais cada vez mais especializados para atuar nessa área. O curso de Especialização em Enfermagem em UTIN, do Centro Universitário Hermínio Ometto (CUHO) existe desde 2002, mas somente a partir de 2005 as publicações passaram a ser realizadas em forma de Anais. O objetivo desse estudo foi analisar as produções científicas da Especialização em Enfermagem em Terapia Intensiva Neonatal, publicada nos Anais dos Fóruns de Pós Graduação em Enfermagem, do CUHO. Foi realizada uma pesquisa retrospectiva documental, a qual foi investigada os seis anais publicados dos Fóruns de Pós Graduação em Enfermagem, do Curso de Especialização em Enfermagem em Terapia Intensiva Neonatal, do CUHO. Esse estudo foi aprovado pelo Comitê de Ética do CUHO, respeitando os princípios éticos e bioéticos da pesquisa em seres humanos conforme resolução n. 196/96, sob o parecer n. 562/2011. Após o levantamento dos dados, foram obtidos os seguintes resultados, emergindo os temas: assistência de enfermagem; humanização; administração em enfermagem; assistência de enfermagem e humanização; assistência e administração em enfermagem. Apesar de esse estudo ser limitado à publicação existente em uma instituição de ensino, foi possível identificar as afinidades pelas temáticas assistência e humanização. Ressalta-se a necessidade de incentivos aos enfermeiros sobre a importância em se pesquisar e divulgar sobre as ações de enfermagem, seja de cunho assistencial, administrativo, de pesquisa e de educação; já que, acredita-se ser a melhor maneira de fortalecer, aprimorar e fundamentar o profissional enfermeiro para uma atuação ética, humanística e científica.
Aplicação do laser e led na alopecia androgenética feminina (AAG)
Authors: Ferreira Ana Flávia , Moreira Juliana Aparecida Ramiro , Silva Ana Claudia Calazans da
Published: July 2023

Introdução: A fotobiomodulação vem sendo amplamente aplicada na área da saúde, principalmente na área da estética, utilizada em tratamentos de diversas disfunções, dentre elas, a alopecia androgenética feminina. O folículo piloso quando estimulado através da fototerapia promove nutrição desse bulbo e, por consequência, ocorre a melhora no quadro de alopecia. Objetivo: O objetivo deste estudo é verificar o efeito do laser e led na alopecia androgenética feminina. Metodologia: O estudo contará com uma voluntária do gênero feminino, com idade de 57 anos, apresentando alopecia androgenética, diagnosticada e avaliada por meio da anamnese capilar, dermatoscópio e fotografia. Logo após foi realizado as sessões de fototerapia, com o aparelho da marca MMO, uma vez na semana, com total de 10 sessões. As aplicações foram realizadas no Laboratório de Estética Corporal da Instituição de Ensino Fundação Hermínio Ometto-FHO. Diante do exposto pela literatura dos benefícios do Laser e LED e do Minoxidil, este estudo associou as duas técnicas para potencializar o tratamento. Após observarmos os resultados e á-los com estudos já publicados, concluise que a aplicação do Laser e Led e a aplicação do Minoxidil home care na alopecia androgenética feminina (AAG) neste estudo de caso foi eficiente para o tratamento da disfunção, uma vez que os resultados obtidos foram satisfatórios e não houve nenhum efeito indesejado para o indivíduo que se submeteu às aplicações. Porém, propõe-se novas pesquisas práticasespecíficas sobre o tema para obter maiores evidências científicas.
Imbibition behaviour and germination response in conventional and quality of Indian mustard (Brassica juncea) seeds
Authors: SWAMI SUNIL , YADAV SANGITA , YADAV SHIV K , DAHUJA ANIL , YADAV DEVENDRA KUMAR
Published: July 2023

Indian mustard [Brassica juncea (L.) Czern and Coss] seeds are well known for their multipurpose uses, such as oilseeds, spices etc. Being extensively cultivated in northern and western part of the country it constitutes major share in country's oilseeds production. Developing cultivars having low erucic acid and glucosinolates (single zero and double zero) is a major objective of worldwide Brassica breeding. Such cultivars are also known as Quality Indian mustard. Seed; being vital input in agriculture, its quality determines the performance of a given genotype and efficiency of all other inputs too. Color variation among the seed coat is known to affect the rate of water uptake and thereby the vigor of seeds and these color variation is mainly because of pigments such as melanin and phenolics compounds. No such studies are reported in Indian mustard, though there is variability with respect to seed coat colour in both conventional and quality type of Indian mustard seeds. Thus the present investigation was carried out with a view to evaluate the imbibitional behaviour in black and yellow seeds of Indian mustard. The material had eight varieties of Indian mustard of which four genotypes each were of conventional and quality types. The seed of these genotypesvaried for seed coat color, i.e. four black seeded and four yellow seeded genotypes. Thus, the material has two genotypes each with black and yellow seed coat from conventional and quality groups. We studied the rate of imbibition in black and yellow seeds and correlated them with the melanin and phenol content. We found that the black seeds were having higher amounts of melanin and phenol content and thus imbibing slowly than yellow seeds. On the other hand, faster imbibition in yellow seeds leads to imbibitional injury which is known to reduce the vigor in Brassica. Use of controlled deterioration revealed the proneness of yellow seeds to ageing and thus reduction in vigor of such seeds. Few yellow seeded cultivars showed resistance to such deterioration and thus could be used in improvement programme in Brassica.
An Exploration of the ‘Gendered’ Dimensions of Women’s Success in Ghana’s Media/Communication Industry
Authors: Abena Animwaa Yeboah  , Esi Eduwaa Thompson
Published: July 2023

Ghana’s return to democracy and a liberalised business environment in 1992 ushered the country into a period characterised by an ever-growing media/communication industry. From journalism, through public relations to advertising, there has been an upsurge in activity and, consequently, in competition. In the midst of this competitive environment, some women have made visible gains, having attained different levels of success evidenced by various awards they and the organisations they lead have won. This is in spite of the numerous challenges that women have been known to face in media-related industries (see for instance Okpara 2006; Steiner 2002). This paper reports findings from interviews with three such women that delved into their career journeys to explore whether there are gender implications for their success.
Représentations de la féminité et de la masculinité dans la presse togolaise : étude de la caricature dans Sika’a, Viva et Pipo magazine
Authors: Kouméalo Anate
Published: July 2023

This article sheds light on the stereotypes and the physical, moral and psychological traits of the femininity and the masculinity as caricatured, in three Togolese humoristic magazines. Thus, the article aims to study the recurrent representations charged with meanings that can be associated with men and women. In the meantime, the article focuses on the perceptive mutations that permeate each genre: the deviations and the stereotypical inversions in male-female relationships. It points, not only, through interviews, to the journalists’ appraisal of their society but also, to the objective of the magazines, created and managed mainly by men and the imaginary produced by the media discourse.
Stock risk and return before and during the covid-19 pandemic
Authors: Liwe Alther Gabriel
Published: July 2023

Based on the type of data used, this research uses a quantitative approach, which places an emphasis on testing theory through measuring research variables with numbers and conducting data analysis with statistical procedures. One of the models used to estimate the rate of return is the Capital Asset Pricing Model (CAPM). The purpose of this study is to examine the level of risk and stock returns during the covid-19 pandemic using the Capital Asset Pricing Model (CAPM) method in companies listed on the Indonesia Stock Exchange (IDX) and to examine differences in the level of risk and stock returns before and during the covid-19 pandemic in companies listed on the Indonesia Stock Exchange. Determination of the sample using the purposive sampling method. There are 488 companies on the Indonesia Stock Exchange (IDX) that meet the criteria, with 98 companies classified as high-risk companies and 390 companies classified as low risk. The results showed that there were no significant differences in risk and stock returns in high-risk companies before and during the pandemic in 2020, 2021, and 2022. There is a significant difference in risk and stock returns in low-risk companies before and during the pandemic in 2021, while there is no significant difference before and during the pandemic in 2020 and 2022. There is a significant difference in risk and stock returns in high- and low-risk companies before and during the 2021 pandemic, while there is no significant difference before and during the 2020 and 2022 pandemics.
Peningkatan Hasil Belajar Tolak Peluru Melalui Penggunaan Media Bola Karet Siswa Kelas VIIA SMP Negeri 3 Teluk Keramat
Authors: Anton Anton
Published: July 2023

Tujuan penelitian ini untuk mengetahui peningkatan hasil belajar melalui penggunaan media bola karet dalam pembelajaran tolak peluru pada siswa kelas VIIA SMP Negeri 3 Teluk Keramat Kabupaten Sambas. Penelitian dilaksanakan di SMP Negeri 3 Teluk Keramat, dengan jumlah subjek siswa di kelas VIIA dengan jumlah 29 orang siswa. Hasil penelitian menunjukan pada prasiklus adalah 29,09. Nilai rata-rata yang diperoleh di prasiklus termasuk dalam kategori kurang, siswa belum sama sekali mengetahui teknik tolak peluru dengan tepat. pada siklus 1 adalah 63,58 dan rentang nilai prosentase pada siklus 1 adalah siswa yang mendapat nilai kurang dari 73 yaitu 68,97%, siswa yang mendapatkan nilai 73-79 yaitu 31,03%. hasil belajar tolak peluru siswa pada siklus 2 adalah 86,42. Ini menunjukkan bahwa sebagian besar kemampuan tolak peluru siswa memiliki peningkatan dari siklus 1 ke siklus 2, hal ini dikarenakan siswa mulai memahami materi yang peneliti berikan serta siswa sudah memiliki keberanian, kesenangan dan percaya diri dalam materi tolak peluru.
From the history of the development of methods of teaching foreign languages
Authors: Sucman Anna
Published: July 2023

This article provides a brief review of the history of methods of Foreign Language Teaching (FLT). The comparative analysis of the FLT methods has been carried out, the advantages and disadvantages of popular methods are discussed. The following methods of FLT are presented: the grammar-translation, the textual-translation, the direct method, audiolingual method, audiovisual method, the comparative method, old humanistic methods, communicative language teaching. Today we have a variety of methods of FLT at our disposal and we can choose methods according to the needs of our modern society. When the method becomes unfashionable, some of its techniques or ideas are often borrowed by another new method. This work is an attempt to identify the most effective and popular FLT method of the present time.
Factores asociados al abandono del control prenatal en gestantes atendidas en el centro de salud Chosica categoría I-3 en el período del 2016 al 2018
Authors:   , Palomino Vargas Celina
Published: July 2023

OBJETIVO GENERAL: Determinar los factores asociados al abandono del control prenatal en gestantes atendidas en el Centro de Salud Chosica categoría I-3 en el período del 2016 al 2018. MÉTODOS Y MATERIALES: Se ejecutó un estudio de tipo analítico, de caso y control, retrospectivo, observacional y transversal con una muestra de 214 gestantes atendidas en el Centro de Salud Chosica en el período del 2016 al 2018. RESULTADOS: Los factores asociados al abandono del control prenatal en el presente trabajo son: los factores sociodemográficos como la edad (p=0.028, OR=1.832, IC=1.064-3.154), estado civil (p=0.006, OR=2.138, IC=1.237-3.695), ocupación (p=0.000, OR=3.439, IC=1.960-6.032), y lugar de procedencia (p=0.000, OR=3.456, IC=1.967-6.072); los antecedentes patológicos (p=0.014, OR=1.983, IC=1.149-3.422); la paridad (p=0.000, OR=6.594, IC=3.630-11.977); y la violencia basada en género (p=0.019, OR=1.921, IC=1.110-3.323). Dentro de la variable factores sociodemográficos, el indicador grado de instrucción fue el que no evidenció significancia para el abandono del control prenatal. CONCLUSIONES: Los factores asociados al abandono del control prenatal en el Centro de Salud Chosica en el período del 2016 al 2018 fueron los factores sociodemográficos como: edad, estado civil, ocupación y lugar de procedencia, los antecedentes patológicos, la paridad y la violencia basada en género
Spatial Variability of Infiltration Rate in Inceptisol and Entisol Soils of Sahyadri Foothills of Western India
Authors: Krishnapriya M. K. , Patil G. D. , Leno N. , Yadav G. K.
Published: July 2023

Aim: To characterize the spatial variability of infiltration in both Inceptisol and Entisol soils of irrigated farms of College of Agriculture, Pune.

Study Design: Ten GPS based locations each from Inceptisol and Entisol were selected randomly and infiltration rates were computed using double ring infiltrometer.

Place and Duration of Study: The research was conducted at irrigated farms of College of Agriculture, Pune, between January 2019- May 2019.

Methods: Soil samples collected from these spots were analysed in lab for its physical and chemical properties and thus to arrives a correlation between infiltration rates and soil physico-chemical properties.

Results: Porosity (r =0.44*), per cent silt (0.58 **), per cent sand (0.57**) and hydraulic conductivity (0.53**) showed positive correlation with the cumulative infiltration rate, while the bulk density (r = -0.44*) and electrical conductivity (-0.84**) gave a negative correlation with the cumulative infiltration rate. Infiltration rates of soil varies with the spatial variability.
Ultraefficient Non‐Doped Deep Blue Fluorescent OLED: Achieving a High EQE of 10.17% at 1000 cd m−2 with CIEy<0.08
Authors: Du Chunya , Liu Hui , Cheng Zhuang , Zhang Shaoqin , Qu Zexing , Yang Dezhi , Qiao Xianfeng , Zhao Zujin , Lu Ping
Published: July 2023

The pursuit for efficient deep blue material is an ever‐increasing issue in organic optoelectronics field. It is a long‐standing challenge to achieve high external quantum efficiency (EQE) exceed 10% at brightness of 1000 cd m−2 with a Commission International de L'Eclairage (CIEy) <0.08 in non‐doped organic light‐emitting diodes (OLEDs). Herein, this study reports a deep blue luminogen, PPITPh, by bonding phenanthro[9,10‐d]imidazole moiety with m‐terphenyl group via benzene bridge. The non‐doped OLED based on PPITPh exhibits an exceptionally high EQE of 11.83% with a CIE coordinate of (0.15, 0.07). The EQE still maintains 10.17% at the brightness of 1000 cd m−2, and even at a brightness as high as 10000 cd m−2, an EQE of 7.5% is still remained, representing the record‐high result among non‐doped deep‐blue OLEDs at 1000 cd m−2. The unprecedented device performance is attributed to the reversed intersystem crossing process through hot exciton mechanism. Besides, the maximum EQE of orange phosphorescent OLED with PPITPh as host is 32.02%, and remains 31.17% at the brightness of 1000 cd m−2. Such minimal efficiency roll‐off demonstrates that PPITPh is also an excellent phosphorescent host material. The result offers a new design strategy for the enrichment of high‐efficiency deep blue luminogen.
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency
Authors: Valenzuela Rodrigo , Metherel Adam H. , Cisbani Giulia , Smith Mackenzie E. , Chouinard‐Watkins Raphaël , Klievik Brinley J. , Videla Luis A. , Bazinet Richard P.
Published: July 2023

The synthesis rates of n‐3 and n‐6 polyunsaturated fatty acids (PUFAs) in rodents and humans are not agreed upon and depend on substrate availability independently of the capacity for synthesis. Therefore, we aimed to assess the activities of the enzymes for n‐3 and n‐6 PUFA synthesis pathways in liver, brain, testicle, kidney, heart, and lung, in relation to their protein concentration levels. Eight‐week‐old Balb/c mice (n = 8) were fed a standard chow diet (6.2% fat, 18.6% protein, and 44.2% carbohydrates) until 14 weeks of age, anesthetized with isoflurane and tissue samples were collected (previously perfused) and stored at −80°C. The protein concentration of the enzymes (Δ‐6D, Δ‐5D, Elovl2, and Elovl5) were assessed by ELISA kits; their activities were assayed using specific PUFA precursors and measuring the respective PUFA products as fatty acid methyl esters by gas chromatographic analysis. The liver had the highest capacity for PUFA biosynthesis, with limited activity in the brain, testicles, and kidney, while we failed to detect activity in the heart and lung. The protein concentration and activity of the enzymes were significantly correlated. Furthermore, Δ‐6D, Δ‐5D, and Elovl2 have a higher affinity for n‐3 PUFA precursors compared to n‐6 PUFA. The capacity for PUFA synthesis in mice mainly resides in the liver, with enzymes having preference for n‐3 PUFAs.
A resilience‐based framework for assessing the evolution of open source software projects
Authors: Kritikos Apostolos , Stamelos Ioannis
Published: July 2023

Open source software (OSS) has been developing for more than two decades. It originated as a movement with the introduction of the first free/libre OSS operating system, became a popular trend among the developer community, led to enterprise solutions widely embraced by the global market, and began garnering attention from significant players in the software industry (such as IBM's acquisition of RedHat). Throughout the years, numerous software assessment models have been suggested, some of which were created specifically for OSS projects. Most of these assessment models focus on software quality and maintainability. Some models are taking under consideration health aspects of OSS projects. Despite the multitude of these models, there is yet to be a universally accepted model for assessing OSS projects. In this work, we aim to adapt the City Resilience Framework (CRF) for use in OSS projects to establish a strong theoretical foundation for OSS evaluation focusing on the project's resilience as it evolves over time. We would like to highlight that our goal with the proposed assessment model is not to compare two OSS solutions with each other, in terms of resilience, or even do a resilience ranking between the available OSS tools. We are aiming to investigate resilience of an OSS project as it evolves and identify possible opportunities of improvements in the four dimensions we are defining. These dimensions are as follows: source code, business and legal, integration and reuse, and social (community). The CRF is a framework that was introduced to measure urban resilience and most specifically how cities' resilience is changing as they evolve. We believe that a software evaluation model that focuses on resilience can complement the pre‐existing models based on software quality and software health. Although concepts that are related to resilience, like sustainability or viability, already appear in literature, to our best knowledge, there is no OSS assessment model that evaluates the resilience of an OSS project. We argue that cities and OSS projects are both dynamically evolving systems with similar characteristics. The proposed framework utilizes both quantitative and qualitative indicators, which is viewed as an advantage. Lastly, we would like to emphasize that the framework has been tested on the enterprise software domain as part of this study, evaluating five major versions of six OSS projects, Laravel, Composer, PHPMyAdmin, OKApi, PatternalPHP, and PHPExcel, the first three of which are intuitively considered resilient and the three latter nonresilient, to provide a preliminary validation of the models' ability to distinguish between resilient and not resilient projects.
The Prognostic Nutritional Index is a Predictive Marker for Postoperative Complications in Patients with Late‐Onset Ulcerative Colitis
Authors: Kato Hirochika , Seishima Ryo , Nakamura Kimihiko , Matsui Shimpei , Shigeta Kohei , Okabayashi Koji , Kitagawa Yuko
Published: July 2023

Purpose

The number of patients with late‐onset ulcerative colitis (UC) requiring surgery has increased in recent years. The risk of postoperative complications is higher in the elderly, so preoperative assessment is important. We aimed to explore the performance of preoperative assessment of nutritional markers for predicting postoperative complications in patients with late‐onset UC.

Methods

We retrospectively analysed 140 medically refractory UC patients who underwent surgery. The association between age at UC onset and risk of postoperative complications was explored using a fractional polynomial model. Uni‐ and multi‐variate logistic regression analyses were performed to identify nutritional markers associated with postoperative complications.

Results

The polynomial model showed patients with UC onset after 50 years of age had an increased risk of postoperative complications. Late‐onset (LO) UC, an onset occurring after 50 years old, was associated with a higher risk of incisional surgical site infection (SSI) and intra‐abdominal abscess than early‐onset (EO) UC. Compared with the EO group, the LO group had fewer nutritional markers that were significantly associated with postoperative complications. The prognostic nutritional index (PNI) was calculated using the albumin level and the total lymphocyte count, and it was the only index that was significant in the LO group (odds ratio 0.872 95% CI 0.77–0.99, P = 0.03).

Conclusions

It was more difficult to use nutritional status to predict the risk of postoperative complications in patients with late‐onset UC than in patients with early‐onset ulcerative colitis. PNI may be a useful nutritional marker for patients with both late‐ and early‐onset UC.
The Impact of COVID-19 on Breast Reconstruction: A Nationwide Analysis Utilizing NSQIP
Authors: Pires Giovanna R. , Moss Whitney D. , Sudduth Jack D. , Marquez Jessica L. , Mills Andrew , Samlowski Erika , Clinker Christopher , Eddington Devin , Hobson Greg
Published: July 2023

Background The coronavirus disease 2019 (COVID-19) global pandemic prompted an unprecedented contraction in surgical volume. This utilizes the American College of Surgeons' National Surgical Quality Improvement Program (NSQIP) database to assess the impact of COVID-19 on breast reconstruction surgery volume and quality throughout 2020.

Methods The NSQIP database was utilized to gather data from 2015 to 2020. We provide descriptive statistics in the form of mean (standard deviation), median (interquartile range), and range for continuous variables and counts (%) for categorical variables. A Kruskal–Wallis test was used to compare average age and a chi-squared test was used to compare other demographic categorical variables from 2019 to 2020.

Results Breast reconstruction procedures decreased by 27% in Q2 2020 compared to Q2 of 2019. Immediate tissue-expander-based reconstruction was the only type of reconstruction that increased in comparison to Q2 2019 values (53.5 vs. 41.1%, p < 0.001). Rates of delayed direct to implant reconstruction was decreased (12.8 vs. 17.5%, p < 0.001) and free flap-based breast reconstruction decreased, including immediate free flap reconstruction (5.3 vs. 9%, p < 0.001) and delayed free flap reconstruction (5.7 vs. 9.1%, p < 0.001). Immediate direct to implant reconstruction rates were unchanged. In terms of surgical quality, there were no statistically significant increases in postoperative complications, readmissions, or reoperations.

Conclusion Breast reconstruction surgery was heavily impacted in Q2 of 2020 with a 27% decrease in total surgical volume. There was an increase in immediate tissue-expander-based reconstruction and decrease in rates of both direct to implant and free-flap based reconstruction. Surgical quality and outcomes remained unchanged through the pandemic.
Enacting the tween news viewer
Authors: Lorgen Linn C. , Sørenssen Ingvild Kvale
Published: July 2023

Norway’s public service provider, NRK, delivers daily news for tweens through Supernytt. Employing the concepts of mutual enactment, assemblages, and multiplicity, this chapter explores the elusive interdependencies of children’s news and its viewers. Through textual analysis of Supernytt and interviews with tweens, the text and children’s utterances are pushed and pulled in and out of focus to explore enactments of “the tween news viewer”. The authors find that both the text and children themselves take part in multiple enactments of the tween news viewer and argue that the conceptual framework used aids in exploring the constantly unfolding interdependencies of children and media.
“Going standard” on a blank page
Authors: Raimondi Gianmario , Angster Marco , Bellante Marco , Mas Paolo Benedetto , Cioffi Raffaele , Gaeta Livio , Pons Aline , Rivoira Matteo
Published: July 2023

This chapter investigates non-standard languages,
i.e., those which are dialectal, non-standardised – or standardised
to a very limited extent, represented by the local linguistic
varieties that populate the Italian Western Alps. Despite the fact
that these have almost exclusively existed as spoken languages
throughout their history, our particular aim is to discuss methods
and problems raised by the investigation of written corpora of these
varieties from a corpus linguistics perspective. This is especially
challenging because corpus linguistics usually employs methods and
standards elaborated for standard(ised) written varieties. Focusing
the Occitan and Francoprovençal varieties, it is shown that the
different historical backgrounds of the two languages also have an
impact on their speakers’ attitude towards standardisation and on
how texts are produced and accordingly made accessible for corpus
linguistics methods.
Dialectology as a matter of gradience
Authors: Pascua Borja Alonso
Published: July 2023

This article demonstrates how corpus linguistics
may help to unveil the gradience of dialectal phenomena through a
study of the remote present perfect (PP) in European Spanish. I will
address how the fulfilment of certain conditions may account for the
use of Spanish aoristic PP, and whether this is reflected in a
geographical pattern mirroring its degree of grammaticalization. To
this end, a sample taken from the Audible Corpus of Spoken
Rural Spanish is analysed and mapped. The evidence
supports the proposal that Spanish remote PP exhibits traits of a
geographically influenced gradient phenomenon, as strongly
grammaticalized PPs concentrate in focal areas, while those whose
presence is more easily explained from context are spread out around
the periphery.
Theorizing a postmodern translator education
Authors: Washbourne Kelly
Published: July 2023

The goal of this article is to unite the different strands of postpositivist thinking about translator education, including both axiological and epistemological, as well as the often-neglected political dimensions. Accordingly, the study considers evidence-based versus values-based education, performativity, dialogue, deconstruction, reflexivity, emergentism, border pedagogy, complexity, pluralism, and the enactment of “multiple voices” (González-Davies 2004). Thirteen postmodern notions and their implications for translation pedagogics are surveyed, including ethics, intersubjectivity, shifting classroom power structures, and the dilemma of canon. How are uncertainty and fragmentariness reconciled with the inherent progress-orientedness of the educational project? And significantly, how is postmodern consciousness enacted in classroom practice? In seeking what Torres del Rey (2002, 271) calls a more participatory and reflexive educational context, I entertain postmodern teaching and learning in the discipline as a possible approach to active, flexible, creative, collaborative, and inclusive roles and identities for both facilitators and learners.
Non‐medical formula use in newborn infants still common at two Swedish hospitals after a breastfeeding support program
Authors: Andresen Erika , Oras Paola , Norrman Gunilla , Målqvist Mats , Funkquist Eva‐Lotta
Published: July 2023

Aim

To evaluate the effectiveness of a breastfeeding support programme on reducing infant formula use and to investigate indications for formula in newborn infants in Sweden.

Methods

A quasi‐experimental study design was carried out. It included 255 mother‐infant pairs in a control group, who received standard care and 254 pairs in an intervention group, who took part in a breastfeeding support programme. Data were collected by reviewing patient records from two regional hospitals in Uppsala and Gotland and recruitment took place between 2017 and 2019.

Results

Median age of mothers were 31 years (range 20–49) and median gestational age of infants were 39 + 6 weeks/days (range 37 + 0 to 42 + 4). The intervention did not reduce infant formula use. In total, 87/507 (17%) of the infants received formula. Among children receiving formula 30/87 (34%) had a medical indication, whereas 57/87 (66%) had no medical indication. Main reasons for medically indicated formula use were hypoglycaemia, 13/30 (43%), and weight loss, 13/30 (43%). Main reasons for non‐medical use were mothers'/parents' wishes, 25/57 (44%) and infants' dissatisfaction, 11/57 (19%).

Conclusion

Continued efforts are needed to develop effective breastfeeding interventions with increased focus on infant formula reduction.
Histone demethylase PHF8 facilitates the development of chronic myeloid leukaemia by directly targeting BCR::ABL1
Authors: Feng Huimin , Fu Yue , Cui Zelong , Zhou Minran , Zhang Lu , Gao Zhenxing , Ma Sai , Chen Chunyan
Published: July 2023

Although tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukaemia (CML), TKI resistance remains a major challenge. Here, we demonstrated that plant homeodomain finger protein 8 (PHF8), a histone demethylase was aberrantly enriched in CML samples compared to healthy controls. PHF8 inhibited CML cell differentiation and promoted CML cell proliferation. Furthermore, the proliferation‐inhibited function of PHF8‐knockdown have stronger effect on imatinib mesylate (IM)‐resistant CML cells. Mechanistically, we identified that PHF8 as a transcriptional modulator interacted with the promoter of the BCR::ABL1 fusion gene and alters the methylation levels of H3K9me1, H3K9me2 and H3K27me1, thereby promoting BCR::ABL1 transcription. Overall, our study suggests that targeting PHF8, which directly regulates BCR::ABL1 expression, is a useful therapeutic approach for CML.