bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of In-situ Rainwater Conservations and Sowing Date on Barley Yield and Weed Infestation: A Case study at Maychew and Mekelle, Northern Ethiopia
Authors: Gessesse Abrham Tezera , Berhe Araya Alemie
Published: April 2020

One season experiment conducted at two sites in northern Ethiopia (Maychew and Mekelle). The objective of the research was to evaluate the effect of in-situ rainwater conservation and sowing-date on soil-water status, barley yield and infestation of weeds. The treatments include three alternative sowing-dates (ESD; NSD; and LSD) and two in-situ rainwater conservation measures (tie-ridge and soil-bund, replicated three times. Analysis of variance (ANOVA) was applied to evaluate the effect of the treatments on total biomass and rainwater use efficiency (RWUE) of the local barley. The average soil-water content in the upper 0.6 m root zone in the soil-bund and tie-ridge improved over the control treatment by 14% and 24%, respectively. The grain yield on tie-ridge was increased significantly compared to the control at Maychew site. Tie-ridge improved grain yield by 4% and 18% over the control at Mekelle and Maychew, respectively. NSD significantly improved the grain yield over LSD at both experimental sites. Neither of the sowing-dates nor the in-situ rainwater conservation measures had significantly increased the dry-matter of a barley crop. However, when NSD combined with tie-ridge, the grain yield was significantly improved compared to the LSD. There was no significant difference in weed infestation in both experimental sites due to applying in-situ rainwater conservation. But, numbers of weeds were significantly higher in ESD compared to NSD and LSD on both experimental sites. For this reason, NSD with tie-ridging technique can be used as an option to obtain higher barley grain yield.
Tuberculosis Endemic in Bangladesh
Authors: Nayeem Jannatun , Salek Md. Abu
Published: April 2020

Tuberculosis (TB) has been a major public concern of Bangladesh for decades. According to the World Health Organization (WHO), Bangladesh ranks sixth among the 22 high TB-burden countries. Thus in order to improve the TB status, BRAC introduced the tuberculosis control program in 1984 in collaboration with the government. In this paper is carried out on the number of reported cases and deaths from endemic of tuberculosis. Time series analysis performed on this data reveals that tuberculosis infection has been on the rise over the years. The situation is also the same as the number of deaths. Reported cases and death cases are forecasted to carry out using appropriate and reliable method that also indicates in the two related population in this research work.
Deferred anastomosis in severe secondary peritonitis using a temporary intestinal shunt – case report
Authors: Rey-Simó Ignacio , García-Novoa Alejandra , Correa-Marín Jessica , Gómez-Alférez Alden Pool
Published: April 2020

Introduction: As part of the damage control surgery concept applied to the treatment of sepsis due to severe secondary peritonitis following intestinal perforation and/or in high-risk patients we describe the novel "temporary intestinal shunt" (TIS) technique with delayed intestinal anastomosis, as an alternative to primary anastomosis or enterostomy.

Material and Methods: We present three patients in whom urgent laparotomy was performed due to intestinal perforation, with intestinal resection and TIS.

Case reports:Case 1: A 39-year-old male presented with acute myeloid leukemia M3 and generalized peritonitis, sigmoid colon perforation and secondary jejunal loop involvement. In view of these findings, we performed 10 cm jejunal resection with TIS placement, sigmoid colon resection, and negative pressure therapy (NPT). Reoperation after 48 hours showed no evidence of peritonitis, so a manual jejuno-jejunal anastomosis and terminal colostomy were performed. Case 2: A 65-year-old woman treated with corticosteroids presented with a pneumoperitoneum secondary to a road traffic accident. Urgent laparotomy revealed a 2 cm jejunal perforation. Resection of the jejunal segment and TIS with NPT was performed. Exploration of the peritoneal cavity 96 hours later showed clinical improvement and a jejuno-ileal anastomosis was performed. Case 3: A 73-year-old male was admitted due to intestinal subocclusion. Clinical deterioration occurred rapidly and we performed an urgent laparotomy diagnosing jejunal perforation secondary to torsion and ischemia of the affected loop, and generalized peritonitis. Intestinal resection and TIS with NPT placement were thus decided. Anastomosis and closure of the abdominal appendage were deferred until 96 hours after the first surgery.

Conclusion: Although the evidence we present is limited, we believe TIS to be an additional tool in damage control surgery. This staged management strategy allows definitive reconstruction with the patient in a more favorable physiological condition.
Seasonal variations affect the physical and chemical parameters of inland waters: a case study of Warri River in Nigeria
Authors: Idomeh Joyce E. , Isokpehi Nnenna  A. , Shittu Olufunke B. , Fasina Kolapo A.
Published: April 2020

The Niger-Delta area in Nigeria is rich with rivers, swamps and creeks that are often subject to various forms of pollution. The effect of seasonal variations on the physical and chemical conditions of Warri River was studied in 2015. Temperature and pH values across all seasons fell within the optimum range formost aquatic organisms. Meanwhile, total dissolved solids exceeded the World Health Organization (WHO) permissible limit, especially during the dry season; indicating possible pollution from inorganic salts, organic matter and other dissolved materials in the water. The low dissolved oxygen value recorded was expected due to the high levels of dissolved solids recorded in the river. Lastly, phosphate, nitrate and sulphate concentrations recorded were below the WHO permissible limits. The chemical and biological parameters recorded indicate that the Warri River poses minimal threat to human and animal life.
Preliminary screening of pesticides used by farmers in North West Cameroon
Authors: Nguemo Charlie C. , Tita Margaret , Abdel-Wahhab Mosaad A.
Published: April 2020

This study aimed to evaluate pesticide use in farmers in Tubah, North West of Cameroon. The data collected would be valuable for pesticide policies to reduce the effects of pesticides on human health and the environment. This survey was carried out in November and December 2016 in Tubah Sub-Division, located in Mezam Division region of North West Cameroon. A survey was conducted on 120 homesteads of the area of the study. The results revealed that 80% of farmers were female. 59.2% had completed primary education whereas no tertiary education was reported among respondents. Insects were the major pests (67.5%) followed by fungi (19.2%), and finally rodents (11.7%). The commonly used pesticides were insecticides; however, herbicides were also used before planting. 19.2% of the farmers fed their livestock and poultry pesticide-treated crops. This study found that farmers in Bambili lacked knowledge in safe handling and use of pesticides. Training programs should be applied to minimize the adverse hazards of pesticides on human health and the environment.
¿Un Gardel venezolano? El día que me quieras de José Ignacio Cabrujas
Authors: Artesi Catalina Julia
Published: April 2020

En este artículo se aborda la idea del mito y la forma en la que un Carlos Gardel se transforma en un mito que trasciende las fronteras de la Argentina para ser un ser mítico latinoamericano. A lo largo del trabajo la autora aborda en primer lugar el mito gardeliniano enmarcándolo entro de una realidad mayor, la de los mitos populares de América Latina en el contexto de una supuesta pérdida de la identidad, sus alcances y cómo su figura fe tomada por dramaturgos de distintas épocas y de distintos países, entre ellos Chile, Venezuela y Uruguay. Luego se detiene en el estudio de José Ignacio Cabrunas y la obra El día que me quieras para intentar, por último, reflexionar acerca de esta obra y su vigencia, cuando en los comienzos del tercer milenio las utopías en Latinoamérica pugnan por resurgir, a pesar de la globalización.
Ricardo Carpani: arte, gráfica y militancia política
Authors: Maddoni Alejandra Viviana
Published: April 2020

La idea central de este ensayo es realizar un recorrido histórico y reflexivo en torno a la obra compuesta por afiches, ilustraciones y volantes del artista plástico argentino Ricardo Carpani que produjo esencialmente a partir de 1960. Como señala su autora, este recorte posee límites frecuentemente caprichosos e imprecisos sobre una producción muy vasta que está signada por una profunda convicción ideológica. En la búsqueda de la identidad latinoamericana, su autora propone que acercarse y recorrer su obra artística puede significar una apropiación - al menos por un momento - de las utopías de entonces, a fin de sostener, dar sentido y actualizar las propias.
La identidad como proceso de construcción. Reapropiaciones de textualidades isabelinas a la luz de la farsa porteña
Authors: Pontoriero Andrea
Published: April 2020

La identidad como un proceso de construcción, tal como se titula este ensayo es su tema central. Pero desde su inicio la autora señala que esa construcción es sumamente compleja pues en ella pugnan dos aspectos diferentes que se integran, el de la identidad propia y al mismo tiempo en relación al campo cultural de los países centrales. Hace su análisis desde las textualidades las isabelinas que si bien no tuvieron origen en América han resultado muy productivas en estas culturas, generando múltiples relecturas que ponen en crisis modelos hegemónicos de cómo se conciben el poder, los lazos sociales y familiares. La intención del artículo es re-elaborar algunas apropiaciones de las textualidades shakesperianas y su re-elaboración para metaforizar momentos coyunturales y traumáticos de la historia latinoamericana.
Latinoamérica en la trama del Diseño. Entre la utopía y la realidad
Authors: Cichello Ariel , Valdés de León Gustavo
Published: April 2020

En el ensayo de Gustavo Valdés de León se realiza un profundo análisis de las interrelaciones teóricas y pragmáticas del Diseño como disciplina emblemática de la Modernidad con la realidad -histórica, económica, cultural y política- de Latinoamérica. Para armar esta idea su autor realiza la operación de desarmar metafóricamente una gran caja llena de conceptos que es necesario comprender en profundidad para llegar a pensar en el diseño latinoamericano. Por este motivo, e intentando presentar en todo momento un recorrido por el diseño de América latina, hace referencia al diseño en sí, a Latinoamérica, su nombre y su historia, la relación entre resistencia e hibridación, como se pasa de una etapa de resistencia a otra caracterizada por la imitación.
La consagración de la Catedral de Lima a través de una rara medalla conmemorativa, 1625
Authors: Álvarez-Carrasco Ricardo
Published: April 2020

El objeto de la presente investigación es la descripción del devenir histórico de la Basílica Catedral Metropolitana de Lima durante sus primeros noventa años de existencia, entre 1535 y 1625, es decir desde su primera fundación hasta el acto de consagración, a propósito del hallazgo de una rara medalla que conmemoraba este último acto.
La hipoxia y los aportes peruanos a los estudios en las grandes alturas - Premio Nobel de Fisiología y Medicina 2019
Authors: Gonzales Gustavo F. , Guerra-García Roger
Published: April 2020

El Premio Nobel de Fisiología y Medicina del 2019 ha sido otorgado a tres investigadores por el descubrimiento de cómo las células de los metazoarios perciben los cambios de la disponibilidad de oxígeno y responden a estos cambios. El trabajo de los tres galardonados William Kaelin, Gregg Semenza y Peter Ratcliffe sobre la manera en que las células se regulan frente a la disponibilidad de oxígeno permite avizorar estrategias terapéuticas para el tratamiento de diferentes tipos de cáncer, así como de la anemia. Este premio también permite relucir la contribución que la escuela peruana ha dado a la ciencia por sus estudios de cómo los organismos pueden nacer, crecer y desarrollarse bajo las condiciones de hipoxia que les impone el vivir a grandes alturas.
Development of Artificial Skin Using Keratin Film for Evaluation of Puncture Performance of Microneedle
Authors: Nishino Ryo , Aoyagi Seiji , Suzuki Masato , Ueda Atsushi , Okumura Yuki , Takahashi Tomokazu , Hosomi Ryota , Fukunaga Kenji , Uta Daisuke , Takazawa Tomonori , Fujii Toshihiro ,   Kansai University 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan,   University of Toyama 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan,   Gunma University 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan,   Shinsyu University 3-15-1 Tokida, Ueda, Nagano 386-8567, Japan
Published: April 2020

Humans do not feel pain when bitten by mosquitos; therefore, we have attempted to develop a microneedle that mimics the puncturing mechanism of mosquitos. We have quantitatively evaluated the puncturing performance of the developed microneedle by puncturing an artificial skin made from polydimethylsiloxane (PDMS), a kind of silicon rubber. Unlike the mono-layered PDMS, however, animal skin including human skin is structured to have a hard stratum corneum, epidermis and dermis over soft subcutaneous tissue. In this paper, we propose an artificial skin having a two-layered hard/soft structure, constructed from PDMS with a human-hair-derived keratin film adhered onto the top surface. We evaluated the hardness of the keratin film (Young’s modulus) and found that it could qualitatively simulate the hard layers of the skin including the stratum corneum. The artificial skin we developed reproduced the following phenomena: the decrease in resistance force of animal skin at the point when the needle penetrates the surface followed by variation in resistance due to the stick-slip phenomenon as the needle penetrates more deeply.
Effect of Inner Diameter and Anticoagulation Coating in a Microneedle on its Blood Suction Performance
Authors: Aoyagi Seiji , Nomura Ryosuke , Takahashi Tomokazu , Suzuki Masato ,   Kansai University 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan,   Murata Machinery, Ltd. 136 Takeda-Mukaishiro-cho, Fushimi-ku, Kyoto 612-8686, Japan
Published: April 2020

As a part of the development of a minimally invasive hollow microneedle designed to mimic a mosquito proboscis, we evaluated the relationship between the needle inner diameter (ID) and blood sucking performance. If the ID is thinned to reduce pain upon piercing skin, blood could clog the tube owing to coagulation, and a sufficient volume of blood might not be obtained. In this study, laser stereo-lithography is used to easily fabricate microtubes of several sizes, at 20–50 μm ID and a fixed length of 500 μm, through which human whole blood is sucked by a vacuum pump. The results indicate that the ID of the tube must be at least 20 μm to prevent hemolysis and at least 50 μm to enable extraction of 200 μL of blood, which is necessary for general blood tests. Moreover, anticoagulant coating applied on the inner wall prevents the clogging of blood and increases the volume of extracted blood.
Human Mimetic Forearm and Hand Design with a Radioulnar Joint and Flexible Machined Spring Finger for Human Skillful Motions
Authors: Kawaharazuka Kento ,   Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Makino Shogo , Kawamura Masaya , Nakashima Shinsuke , Asano Yuki , Okada Kei , Inaba Masayuki
Published: April 2020

Humans have characteristic forearm and hand structures, and most of the previously developed humanoids are not equipped with them. The human forearm has a radioulnar structure composed of two long thin bones, and the human hand has flexibility to move to fit the object and strength to support the human body. Therefore, we develop a novel miniature bone-muscle module integrating bone and muscle structures, and realize the human radioulnar structure. In addition, we develop a novel finger, which is flexible and robust, by using machined springs. We integrate them and construct a forearm and hand system which imitates human joint structures, muscle arrangements, proportion, and weight. Using this forearm and hand system, we realize several human skillful motions.
Estudo da relação entre precipitação e deslizamentos no município de Petrópolis – RJ
Authors: Petrungaro Torres Giselle , Rodrigues do Carmo Luiz Felipe , Pinto de Almeida Palmeira Ana Cristina
Published: April 2020

O município de Petrópolis, na Região Serrana do estado do Rio de Janeiro, por muitas vezes é atingido por desastres naturais, como deslizamentos de terras. Na maioria das vezes são desencadeados por eventos meteorológicos. Devido a essa problemática, foi realizado este estudo que tem como base a relação entre atmosfera e solo, para evidenciar esta relação citada e possibilitar traçar estratégias de prevenção e mitigação dos impactos de tais eventos. Foram utilizados dados de ocorrência de deslizamentos, classificados de acordo com o tipo, em conjunto com os registros de precipitação no município de Petrópolis em determinada série temporal e através de ferramentas gráficas computacionais, foram geradas correlações, análises temporais e espaciais. Os resultados preliminares mostraram a maior relação entre acumulados de chuva e determinadas classificações de deslizamentos. Um exemplo foi no caso das corridas de lama, no qual mostrou a relação destes eventos com as características do local da ocorrência.
Defining Internationalization Strategies of Indonesian Universities through Educational Investment Preferences
Authors: Melati Inaya Sari , Yulhendri Yulhendri , Purasani Hana Netti
Published: April 2020

The internationalization program for higher education is a promising investment with a valuable return. However, it needs a huge budget. This research aims to analyze investment preferences of 13 internationalization program dimensions in Indonesian universities which aggressively encourage themselves to be a world-class university in the future. The novelty in this research is the usage of investment preference index in determining investment priorities in universities instead of common business entities. The quantitative approach was used by calculating the investment preference index. The research instrument used questionnaire with Likert Scale. Respondents were 190 people including students and lecturers. Based on the investment preference index, the number of international students in undergraduate program had to be the first focus in allocating the money for educational investment, followed by the number of international students in postgraduate program and student exchange program. Meanwhile, international links became the least aspect in educational investment preferences.
The Relationship Between Medicaid Coverage and Outcomes Following Total Knee Arthroplasty
Authors: Lakomkin Nikita , Hutzler Lorraine , Bosco Joseph A.
Published: April 2020

Background:

Access to elective total knee arthroplasty is important in the treatment of end-stage arthritis, and numerous initiatives, including Medicaid expansion, have sought to improve patients’ ability to undergo this procedure. However, despite this, the role of Medicaid insurance in patient outcomes remains unclear. The purpose of this study was to perform a systematic review of the literature to explore the relationship between preoperative Medicaid insurance status and outcomes following primary total knee arthroplasty.

Methods:

A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify studies examining outcomes in patients who had Medicaid and were undergoing total knee arthroplasty. Studies including complex revision operations or less common indications for total knee arthroplasty were excluded. Data on insurance status, postoperative complications, length of stay, readmissions, and subsequent revision surgical procedures were collected for each article.

Results:

A total of 13 studies showing 6.18 million patients undergoing total knee arthroplasty were included in the qualitative synthesis. Seven analyses described an important association between Medicaid coverage and short-term readmissions, and 2 analyses showed a relationship between Medicaid and prolonged length of stay. However, the included studies did not describe a significant association between Medicaid and postoperative mortality or revision rates.

Conclusions:

Patients with Medicaid undergoing total knee arthroplasty may be more likely to experience an increased length of stay and to be readmitted postoperatively. The unique factors associated with these patients may help to inform customized perioperative surveillance and optimization to improve outcomes in this group.

Level of Evidence:

Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Acetabular Component Migration Measured Using Radiostereometric Analysis Following Revision Total Hip Arthroplasty
Authors: Abrahams John M. , Callary Stuart A. , Munn Zachary , Jang Sung Won , Huang Qiang , Howie Donald W. , Solomon Lucian Bogdan
Published: April 2020

» Radiostereometric analysis (RSA) studies of acetabular component migration following revision total hip arthroplasty (THA) have a large variation in their methodology and reporting of results, and, therefore, they may not be directly comparable. Standardization of RSA reporting is recommended.

» In our review of RSA studies, there was a trend for cemented acetabular components to have larger amounts of early proximal migration than uncemented acetabular components. Results regarding cemented and uncemented components should be reported separately.

» Cohorts that addressed larger acetabular defects were associated with a larger amount of early migration.

» Reporting the migration result at 1 and 2 years postoperatively may enable earlier identification of poorly performing implants.
Alfabetización en salud pública ante la emergencia de la pandemia por Covid-19
Authors: Lazcano-Ponce Eduardo , Alpuche-Aranda Celia
Published: April 2020

La alfabetización en salud es el proceso centrado en la obtención del conocimiento, la motivación y las competencias individuales para entender y acceder a información, expresar opiniones y tomar decisiones relacionadas con la promoción y el mantenimiento de la salud, lo que es aplicable en diferentes contextos, entornos y a lo largo de toda la vida. Esta perspectiva conceptual es muy necesaria ante la emergencia del virus SARS-CoV-2 que produce la enfermedad Covid-19, la cual ha producido una pandemia con efectos devastadores, no sólo desde el punto de vista de la salud, sino también, de manera muy importante, desde el económico, político y social. En este ensayo se tratan de establecer los elementos basados en la evidencia científica que orientan las políticas públicas de prevención y control, entre los que destacan: a) la inteligencia epidemiológica, la cual incluye no sólo la estrategia de vigilancia poblacional sino, ante la imposibilidad real de identificación de todos los casos positivos, la puesta en práctica de estrategias de vigilancia centinela y la vigilancia basada en eventos; b) las medidas de mitigación de la propagación de la epidemia, tales como distanciamiento social e higiene, lavado de manos, cuarentena, restricción de movimiento y utilización de cubrebocas, entre otras; c) medidas de supresión de la transmisión cuando el número de casos es muy elevado, como el endurecimiento de medidas drásticas de encierro en casa; d) fortalecimiento de la capacidad de atención médica en los sistemas de salud e incremento de la capacidad de prevención de la transmisión en los servicios de salud, incluyendo la utilidad de las pruebas diagnósticas; y e) el desarrollo de vacunas profilácticas contra Covid-19, así como la generación de agentes terapéuticos. Todas estas acciones no sólo deben implementarse rápidamente desde la perspectiva multidisciplinaria y multisectorial de la salud pública para contener, prevenir y controlar la epidemia, sino que necesitan obligatoriamente del concurso de la comunidad como responsabilidad compartida. Debido a todo esto, es necesaria la alfabetización en salud pública.
Effect of Cellgevity® Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity and Pharmacokinetic Parameters of Carbamazepine
Authors: Amponsah Seth Kwabena , Nguessan Benoit Banga , Akandawen Martin , Aning Abigail , Agboli Sedem Yawa , Danso Eunice Ampem , Opuni Kwabena Frimpong-Manso , Asiedu-Gyekye Isaac Julius , Appiah-Opong Regina
Published: April 2020

Background: There is considerable evidence that many patients concurrently administer dietary supplements with conventional drugs, creating a risk for potential drug-supplement interaction. The aim of this study was to determine the effect of Cellgevity® supplement on selected rat liver cytochrome P450 (CYP) enzymes. Also, we sought to deternine the effect of Cellgevity® on the pharmacokinetics of carbamazepine, a CYP3A4 substrate. Methods: Male Sprague-Dawley (SD) rats were randomly put into 5 groups and administered (per os) either distilled water (negative control), Cellgevity® (3 separate doses) or phenobarbital (positive control). Modulation of liver CYP enzyme activity was evaluated after 30 days of treatment, using probe substrates, spectroscopic and high-performance liquid chromatographic methods. In the pharmacokinetic study, 12 SD rats were divided into 2 groups administered (per os) carbamazepine plus Cellgevity®, or carbamazepine plus normal saline, both over a period of 14 days. Blood samples from rats in the same group were collected after treatment. Serum samples were prepared and pooled together at each specific sampling time point. Levels of carbamazepine were determined using a fluorescence polarization immunoassay. Results: Activities of rat liver CYP1A1/2, CYP2C9 and CYP2D6 were significantly increased by Cellgevity® after 30-day treament. Pharmacokinetic parameters for rats administered carbamazepine with Cellgevity® vis-a-vis carbamazepine with normal saline were as follows: Cmax; 20 μmol/L vs 11 μmol/L, AUC0→24; 347 μmol.h/L vs 170 μmol.h/L, Ke; 0.28 h-1 vs 0.41 h-1, and t1/2; 2.3 h vs 1.7 h, respectively.Conclusions: Cellgevity® increased the activity of rat CYP1A1/2, CYP2C9 and CYP2D6 enzymes, and altered the pharmacokinetics of carbamazepine in rats.
The impact of having a baby with cleft lip and palate on parents and on parent-baby relationship: the first French prospective multicentre study
Authors: GROLLEMUND BRUNO , Dissaux Caroline , Gavelle Pascale , Martinez Carla Perez , Mullaert Jimmy , Alfaiate Toni , Guedeney Antoine
Published: April 2020

Background : The objective of this prospective, multidisciplinary and multicenter study was to explore the effect of a cleft lip, associated or not with a cleft palate, on parents, on parent-infant relationship, and on the baby’s relational development. It also highlighted how the type of cleft and the timing of the surgery could impact this effect. Method : 158 infants, with Cleft lip with or without Palate, and their parents participated in this multicenter prospective cohort. Clinical evaluations were performed at 4 and 12 months postpartum. The impact on the parents and on the parent-infant relationship was evaluated by the Parenting Stress Index (PSI), the Edinburgh Post-partum Depression Scale (EPDS) and the Impact-on-Family Scale (IOFS). The relational development of the infant was assessed using the Alarm Distress Baby Scale (ADBB). The main criteria used to compare the infants were the severity of cleft and the time of surgery. Results The timing of surgery, the type of malformation or the care structure had no effect on social withdrawal behaviors of the child at 4 and 12 months postpartum (ADBB). Furthermore, early intervention significantly decreased maternal stress assessed with the PSI at 4 months. Parents for whom it had been possible to give a prenatal diagnosis were much better prepared to accept the waiting time between birth and the first surgical intervention (IOFS). Higher postpartum depression scores (EPDS) were found for both parents compared to the general population. Conclusion : A joint assessment of the mental health of both infants and parents is required in the follow-up of cleft lip and palate. Even if most families are remarkably resilient faced with this major cause of stress, a significant proportion of them could require help to deal with the situation, especially during this first year of follow-up. An assessment of the child’s social withdrawal behaviour and of the parental stress and depression appears useful, in order to adapt care to infant and parent’s needs. Trial Registration: ClinicalTrials.gov Identifier: NCT00993993. Registered 10/14/2009 < https://clinicaltrials.gov/ct2/show/NCT00993993?term=grollemund&draw=2&rank=1.
Safety and Efficacy of Hemispherical with Flattened Pole Dual-Mobility Acetabular Cup in Primary Hip Arthroplasty: The SYMCOR-1 study
Authors: Bonin Nicolas , Estour Gilles , Gedouin Jean-Emmanuel , Guyen Olivier , Daoud Frederic Christopher
Published: April 2020

Background: This study estimated the short-term clinical safety and efficacy of hemispherical with flattened pole cobalt-chromium metal-back with porous outer hydroxyapatite coating dual-mobility acetabular cup (HFPC-DM-HA) in primary total hip arthroplasty.Methods: Single-center retrospective observational cohort study of consecutive patients undergoing total hip arthroplasty with a HFPC-DM-HA 2 years prior to study start. Prospective 2-year follow-up with letter and phone questionnaires.Results: Sampling frame: 361 patients including 59 patients (16.3%) in the cohort. 6 patients (10%) lost to follow-up. Median age 77.5 years (range: 67 ; 92), 32% female, median BMI 25.2 kg.m-2 (18.4 to 56.8). Clinical indications: Primary THA in all patients, resulting from primary osteoarthritis in 80% of them. Median follow-up 3.0 years (2.7 to 4.1). Primary endpoint: 2-year implant survival rate: 97% [87, 99]. Prosthetic dislocation: 0%. Secondary endpoint: Modified HHS (pain & functional subscore) improved from baseline 39.7 [34.6, 44.7] to 75.8 [72.1, 79.6] at 1-year and to 86.7 [83.7, 89.7] at 2-year follow-up (p<0.0001).Conclusions: The authors deemed the short-term outcomes of this acetabular cup in primary total hip arthroplasty to be satisfactory.Study registration: clinicaltrials.gov NCT04209374.
H.Pylori Infection Induces CXCL8 Expression and Promotes Gastric Cancer Progress Through Downregulating KLF4
Authors: liu zhengxia , Wu Xiao , Tian Yuanyuan , zhang wanchun , qiao siyuan , xu wenting , liu yakun , Wang Siying
Published: April 2020

Background Tumour-derived CXCL8 facilitates the movement of myeloid-derived suppressor cells (MDSCs), which have the capacity to restrain antitumour immune responses, into the tumour microenvironment. Kruppel-like factor 4 (KLF4) is a potential tumour suppressor in gastric cancer (GC). However, little is known about the correlation between KLF4 and CXCL8 in gastric carcinoma.Methods In this study, we used cellular and molecular biological methods to assess whether these two factors interact in GC.Results We found that the expression levels of CXCL8 and KLF4 were altered in human GC tissues compared to normal gastric tissues in opposite ways. In addition, we found that CagA gene transduction or Helicobacter pylori infection resulted in the upregulation of CXCL8 expression. Knockdown of KLF4 expression increased CXCL8 expression at the protein and RNA levels, whereas overexpression of KLF4 had the opposite effect. Further mechanistic research revealed that KLF4 binds the CXCL8 promoter and negatively regulates CXCL8 at the transcriptional level. Moreover, CXCL8 factor stimulation reduced KLF4 expression, and the CXCL8-mediated increase in GC cell migration and proliferation was reversed by the upregulation of KLF4 expression, eventually promoting neoplasm growth in vivo.Conclusions Taken together, our findings demonstrate that CXCL8 is a decisive downstream target gene of KLF4 in gastric carcinoma. Targeted KLF4 activation could improve the immunosuppressive microenvironment through direct, negative regulation of CXCL8, providing a new potential target to strengthen the efficacy of immunotherapy in patients with GC.
An Inter-Method Reliability Study Comparing Interview Information on Sunlight, Tanning Beds, Food, and Supplement Exposures with Serum 25-Hydroxy Vitamin D Levels
Authors: Cook Linda S. , Li Xichen , Grevers Xin , Pestak Claire R. , Brockton Nigel , Le Nhu , Luo Li
Published: April 2020

Background: We developed a questionnaire designed to capture the vitamin D related exposures of sunlight, tanning bed use, dietary intake, and supplement use, and used an inter-method reliability approach to compare the study method (self-reported information on vitamin D related exposures nearest the blood draw) with serum 25-hydroxy vitamin D (25(OH)D) levels. Methods: This inter-method reliability study included 512 control women from a population-based, case-control study in Alberta, Canada. All women self-reported data on food/supplement intake (average µg/day), sun exposure (cumulative hours/year), and tanning bed exposure (cumulative hours/year) and provided fasting serum samples, measured in duplicate with a DiaSorin immunoassay for 25(OH)D levels. The correlation between participant characteristics and 25(OH)D are described. We used multivariable robust regression to estimate the percent of variation in 25(OH)D explained by our variables of interest. Results: Food intake, sun exposure, and tanning bed exposure had positive and significant correlations with 25(OH)D levels of a similar magnitude (Spearman r= 0.17 to 0.19). Supplement intake (average µg/day, Spearman r= 0.44) had the strongest positive correlation. In both crude and adjusted models (adjusted for age, body mass index, race, smoking, oral contraceptive use, and menopausal status/hormone therapy), we consistently found that food explained 3.1%, supplements 18.9%, sunlight 2.2%, and tanning bed use 3.0% of the variation in 25(OH)D levels, and all variables combined explained 27.5% - 36.0% of the total variation. Conclusions: These results suggest that our comprehensive dietary and light exposure questionnaire may be a reasonable proxy measure of vitamin D status in the recent past when either 25(OH)D measurements or serum samples are not available for study participants.
Hyper-sphere support vector machine based on collaborative knowledge mining and SMO optimization in power load forecasting
Authors: PAN Resheng , Li Hui , WANG Zhidong , PENG Dong , ZHAO Lang , Wang Yongli , Li Fang
Published: April 2020

Background

Due to the influence of power market reform policies, the conversion of power loads has become more and more complicated. The current load forecasting methods have long calculation times and inaccurate volatility load forecasting. The difficulty of forecasting is becoming greater and more accurate. It becomes very important to predict the electrical load. Under this background, this paper proposes the application methods of collaborative knowledge mining and SMO in solving prediction models based on hyperball support vector machine (CKM / SMO-SVM).
Methods

This study first analyzes the impact of historical data on samples and different parameters. The prediction of power load, sample data and various parameters have a significant impact on the prediction results. Secondly, applying weak entropy theory for collaborative knowledge mining, preprocessing sample data and historical information. Third, a short-term power load forecasting system based on the hypersphere support vector machine model is established and the problem is solved by SMO. Finally, the SVM model and BP model are selected for prediction to verify the new model.
Results

Our research proves that the rms relative error of the CKM / SMO-SVM model is only 2.32%, which is 0.67% and 1.56% lower than the SVM and BP models, respectively, and the optimization speed is faster.
Conclusions

The model proposed in this paper utilizes Hyper-sphere SVM which is suitable for Gaussian kernel function to achieve faster and more accurate load forecasting, which can provide more accurate services for energy spot transactions and energy scheduling plans.
Transcriptome-wide isolation and expression profiles of NF-Y gene family in male cone development and hormone treatment of Chinese pine (Pinus tabuliformis)
Authors: Guo Yingtian , Niu Shihui , Li Wei
Published: April 2020

Background

Conifers and angiosperms have difference in reproductive development, especially for flowering. It is known that NUCLEAR FACTOR Y (NF-Y) transcription factor play an important role in flowering, drought stress and GA, ABA signaling, but, little known in auxin, salicylic acid, jasmonic acid, etc. Moreover, the NF-Y genes family has been mainly analyzed in angiosperms, but it has not been comprehensively reported in conifers.
Results

In this study, we identified 9 NF-YA, 9 NF-YB, and 10 NF-YC genes in Pinus tabuliformis using Arabidopsis NF-Y protein sequences as queries. Besides, by comparing conserved regions and phylogenetic relationships of the PtNF-Ys, we found that the NF-Ys were both conserved and altered during evolution. PtTFL2, PtCO, PtNF-YC1 and PtNF-YC4 were exploited by expression profile in male cone development and the correlation analysis. In addition, NF-YC1/4 can interact with DPL by yeast two-hybrid assays and BiFC. The multiple types of phytohormones-responsive cis-elements (ABA, JA, IAA, SA) were present and many NF-Y genes responded positively to SA and as opposed to IAA and JA.
Conclusions

Twenty-eight PtNF-Ys were identified and bioinformatic characterization of NF-Y genes including conserved regions, phylogenetic relationships, gene-motifs, was carried out. Two candidate genes (NF-YC1 and NF-YC4) were found to be involved in the regulation of conifer flowering and gibberellin signalling. The cis-elements and hormone transcriptome analysis revealed that the potential role of NF-Ys in conifers resistance. This study provides the basis for improved understanding of NF-Y genes function in conifers.
Evaluation of the Scale-up and Implementation of Mind, Exercise, Nutrition…Do It! (MEND) in British Columbia: A Hybrid Trial Type 3 Evaluation
Authors: Liu Sam , Weismiller Joy , Strange Karen , Forster-Coull Lisa , Bradbury Jennifer , Warshawski Tom , Naylor Patti-Jean
Published: April 2020

Background The Mind, Exercise, Nutrition…Do it! (MEND) childhood obesity intervention was implemented in British Columbia (B.C.), Canada from April 2013 to June 2017. The study objective was: a) to describe and explore program reach, attendance, satisfaction, acceptability, fidelity, and facilitators and challenges to implementation during scale-up and implementation of MEND in B.C. while b) monitoring program effectiveness in improving children’s body mass index (BMI) z-score, waist circumference, dietary and physical activity behaviours, and psychological well-being.Methods This prospective, pragmatic implementation evaluation (Hybrid Type 3 design) recruited families with children aged 7-13 with a BMI ≥ 85th percentile for age and sex. The 10-week MEND B.C. program was delivered in 27 sites, throughout all five B.C. health regions (Northern, Interior, Island, Fraser, and Vancouver Coastal) over four years. A mixed-method approach was used to collect and analyze the data. Evaluation measures included: program reach, attendance, fidelity, acceptability, satisfaction, facilitators and challenges to implementation, and effectiveness (change in children’s BMI z-score, physical activity, screen-time, eating behaviours, self-esteem and emotional distress).Results 136 MEND B.C. programs were delivered over four years. The program reached 987 eligible children. 755 (76.5%) children completed the program. The average program attendance was 81.5%. Parents reported the program content was easy to understand, culturally suitable for their family, respectful of their family's financial situation and provided adequate information to build a healthy lifestyle. Children achieved significant positive changes across all four evaluation years in BMI z-score, nutrition behaviours, physical activity levels, hours of screen time per week and emotional distress (p<0.05). Challenges to continued program implementation included: recruitment, resource requirement for implementation and the need to tailor the program locally to be more flexible and culturally relevant.Conclusions Scaling up efficacious childhood obesity interventions into real-world settings is critical to combat the obesity epidemic. Future family-based childhood obesity management interventions need to explore strategies to enhance program delivery flexibility while optimizing the use of health care resources.
The Role of Pruriceptors in Enhanced Sensitivities to Pruritogens in a Murine Model of Chronic Compression of Dorsal Root Ganglion
Authors: Wang Tao , Tao Jin , Fang Yehong , Ma Chao
Published: April 2020

Background: Chronic pruritus is a symptom that commonly observed in neurological diseases. It has been hypothesized that the chronic pruritus may result from sensitization of itch-signaling pathways but the mechanisms remain obscure.Methods: In this study, we established a mouse model of chronic compression of dorsal root ganglion (CCD) and injected various pruritogenic and algogenic agents intradermally to the calf skin ipsilateral to the compressed DRG. We additionally investigated if pruritogen-evoked activities of dorsal root ganglion (DRG) neurons is enhanced in this model. The expression of TRPV1, CGRP and H1R was detected with immunoflorescent staining. DRG neurons response to four agents using in vivo calcium imaging.Results: Compared to the naïve mice, a significant increase in itch-related behaviors was observed in the CCD mice after the injection of pruritogens including histamine and BAM8-22, but not after the injection of algogenic agents including capsaicine and 5-HT, although all the above agents evoked enhanced pain-related behaviors toward the injected site. In vivo calcium imaging revealed that compressed DRG neurons exhibited significantly enhanced responses to histamine and BAM8-22. Immunoflorescent staining also showed that the histamine receptor H1 and the capsaicin receptor TRPV1 were significantly upregulated in DRG neurons.Conclusions: Our findings indicated that sensitization of primary pruriceptive neurons may underlie the enhanced itch sensation after chronic compression of DRG neurons in mice, and may play a role in chronic pruritus in neurological diseases.
Diet Quality and Mental Health Amongst Acute Inpatient Psychiatric Patients
Authors: Gill Raveena , Tyndall Sean F , Vora Darshini , Hasan Rashedul , Megna James , Leontieva Luba
Published: April 2020

BackgroundPoor diet quality has been found to be prevalent in people with mental illness [71] and even contribute to mental illness [71]. The purpose of this exploratory study is to examine the relationship between diet quality, mental health problems, socioeconomic variables, physical activity level, and body mass index amongst acute psychiatric inpatients.MethodThe study sample were 100 adult inpatients. Tools administered were Eating Habit Questionnaires (Dana Farber Institute) and the KIDMed index to assess food compliance in accordance with a Mediterranean diet. The Index marks all individuals as either having an “unhealthy score” or “healthy score”. The study utilized a descriptive correlation research design.ResultsThe results showed that 75% of the patients displayed an unhealthy score as per the KIDMed index. The findings displayed an inverse relationship of BMI and the KIDMed score. There was a significant positive correlation between the level of education and the KIDMed score. There is a positive correlation towards increased consumption of sugar in schizophrenic patients. There was no statistical significance between age, gender, income and physical activity with regards to the KIDMed score.Conclusionpsychiatric inpatients display unhealthy eating habits which is likely both an effect of and a contributing factor to the various mental illnesses. Prospective interventional randomized controlled studies are necessary for clarification of cause-effect relationships.
The tunnel approach versus medial approach in laparoscopic radical right hemicolectomy for colon cancer: A retrospective cohort study
Authors: Zhao Yuzhou , zhang xijie , Zhang Junli , Ma Pengfei , Cao Yanghui , Liu Chenyu , Li Sen , Han Guangsen
Published: April 2020

Background: Although Multiple studies showed that the median approach is nowadays the most widely accepted approach according to the “no-touch” principle and safety. However, this approach is a demanding procedure with a steep learning curve and has a high rate of conversion to laparotomy. This aim is to explore the feasibility and safety of tunnel approach in laparoscopic radical right hemicolectomy for colon cancer.Methods：From July 2016 to October 2018, a total of 106 consecutive patients with colon cancer who were subjected to the laparoscopic radical right hemicolectomy in the affiliated cancer hospital of zhengzhou university were enrolled. The patients underwent either tunnel approach (TA) (n=56) or traditional medial approach (MA) (n=50) according to the surgical maneuver performed. The patients' baseline demographics and perioperative results were compared between the two groups.Results: The baseline characteristics did not differ between groups. The blood loss was significantly less [20.0(5.0-40.0) vs. 100(50.0-150.0) , p < 0.001] and operation time was significantly shorter [128.4±16.7 vs. 145.6±20.3min, p < 0.001]in the TA group than those in MA group. Time to first flatus and postoperative hospital stay were similar [3.0(2.0-4.0) vs. 3.0(3-4.0)d，p=0.329; 10.4±2.6 vs. 10.7±3.0d，p=0.506] in both groups. The conversion to laparotomy and complication rates were similar between the groups(0 vs. 6.0%, p = 0.203; 14.3% vs. 18.0%, p =0.603,respectively). There was no treatment-related death in both groups.Conclusions: The tunnel approach in laparoscopic radical right hemicolectomy for colon cancer is a technically feasible and safe procedure as a preferable approach at present compared to those of medial approach, meanwhile this method is easier for beginners to master. Hence this tunnel approach right hemicolectomy is worth recommended.
CT differentiation of gastric ectopic pancreas from gastric stromal tumors
Authors: Wang Jian , LIU Chang , Yang Fang , Zhang Wenming , Ao Weiqun , An Yongyu , Zhang Cui , Dai Bailing , Pu Cailing
Published: April 2020

BackgroundGastric ectopic pancreas (GEPs) is a rare developmental anomaly which is difficult to differentiate it from submucosal tumor such as gastrointestinal stromal tumor (GIST) by imaging methods. So we retrospectively investigated the CT features of them to help us make the correct diagnosis.Materials and MethodsThis study enrolled 17 GEPs and 119 GSTs, which were proven pathologically. We assessed clinical and CT features to identify significant differential features of GEPs from GSTs using univariate and multivariate analyses.ResultsIn univariate analysis, among all clinicoradiologic features, features of age, symptom, tumor marker, location, contour, blurred serosa or fat-line of peritumor, necrosis, calcification, CT attenuation value of unenhancement phase/arterial phase/portal venous phase (CTu/CTa/CTp), the CT attenuation value of arterial phase/portal venous phase minus that of unenhanced phase (DEAP/DEPP), long diameter (LD), short diameter (SD) were considered statistically significant for the differentiation of them. And the multivariate analysis revealed that location, blurred serosa or fat-line of peritumor, necrosis and DEPP were independent factors affecting the identification of them.What's more, ROC analysis showed that the test efficiency of CTp was perfect(AUC= 0.900).ConclusionLocation, blurred serosa or fat-line of peritumor, necrosis and DEPP are useful CT differentiators of GEPs from GSTs. In addition, the test efficiency of CTp in differentiating them was perfect (AUC=0.900).