bluuebunny/crossref_metadata_2025 huggingface dataset:
Building Clinical Simulations With ChatGPT in Nursing Education
Authors: Reid Jason A.
Published: July 2024

Background:

Competency-based nursing education necessitates effective instructional methods and assessment tools for evaluating students' knowledge, skills, and attitudes. Clinical simulation has emerged as a valuable approach, but creating well-crafted simulations traditionally requires substantial time and effort. The advent of artificial intelligence (AI), exemplified by ChatGPT (OpenAI), offers promising advancements in streamlining scenario creation.

Method:

This article explores the application of ChatGPT-3, version GPT-3, created by OpenAI in generating clinical simulation scenarios for nursing education. The focus is on the convenience, speed, and creativity provided by ChatGPT, enabling nurse educators to save time while developing intricate and thought-provoking scenarios.

Results:

ChatGPT generates intricate scenarios that stimulate critical thinking, significantly reducing the time required for nurse educators to create simulations. This AI tool's ability to produce clinical simulations quickly demonstrates its potential to enhance educational experiences in nursing.

Conclusion:

ChatGPT's convenience, speed, and innovative capabilities make it invaluable for constructing dynamic clinical simulations, opening new avenues for innovative instruction in nursing education. This article highlights the transformative role of AI in empowering educators and enhancing educational experiences, showcasing ChatGPT's potential to revolutionize nursing education despite ongoing discussions about its potential negative impacts.

[
J Nurs Educ
. 2024;63(X):XXX–XXX.]
Outcomes of Concept-Based Curricula: An Integrative Review
Authors: Buckner Martha , Camp Sara , Murabito Sandra
Published: July 2024

Background

Complexity and change in health care environments, the rapid pace of knowledge generation, and changing education policy have led to national calls for change in nursing education. Many nursing programs have adopted a concept-based curriculum (CBC) to address these challenges. Yet, much is still uncertain about the outcomes and effectiveness of CBC, which requires large scale, time-consuming, and resource-intensive change.

Method

This integrative review assesses the outcomes of CBC in nursing higher education with a focus on the comparison of CBC to traditional curricula.

Results

The four relevant themes that emerged after an extensive literature review were critical thinking/clinical judgment, NCLEX-RN
©
(National Council Licensure Examination for Registered Nurses) pass rates, graduation rates, and student satisfaction scores. Overall, the evidence base is not robust. A valid and reliable tool to measure clinical judgment is needed. The review specifically addresses CBC effects on student critical thinking and clinical judgment, traditional outcome metrics, (NCLEX-RN success, graduation rates, and student satisfaction), and other perceived benefits.

Conclusion

The authors found promising results on the effect CBC may have on critical thinking and clinical judgment and other perceived benefits. Findings were inconclusive on traditional outcome metrics.

[
J Nurs Educ
. 2024;63(11):725–729.]
A couple of BO equations as a normal form for the interface problem
Authors: Bambusi Dario , Paleari Simone
Published: July 2024

We consider two fluids in a 2-dimensional region: The lower fluid occupies an infinitely depth region, while the upper fluid occupies a region with a fixed upper boundary. We study the dynamics of the interface between the two fluids (interface problem) in the limit in which the interface has a space periodic profile, is close to horizontal, and has a "long wave profile". We use a Hamiltonian normal form approach to show that up to corrections of second order, the equations are approximated by two decoupled Benjamin-Ono equations.
Rumo à universalização da ética do cuidado:
Authors: Hort Evelaynne
Published: July 2024

Este artigo aborda a Ética do Cuidado com foco na perspectiva de Nel Noddings. O objetivo é apontar a possibilidade de uma Ética do Cuidado universalizável, visto que Noddings não oferece critérios sistemáticos para a Ética do Cuidado, pois deseja afastar-se dos conceitos das éticas principialistas e concentrar-se no fator emocional envolvido na moralidade, em especial na educação moral feminina tradicional, inserida no contexto da cultura ocidental patriarcal. Além de buscar uma análise feminista dos conceitos de Noddings. A pesquisa tem como caráter metodológico a revisão bibliográfica narrativa, fazendo uso de obras filosóficas como único material de pesquisa. Verificou-se que há possíveis alternativas para que a Ética do Cuidado se torne universalizável através da ética do cuidado responsável, para isso construiu-se uma diferenciação entre emoções naturais e emoções morais, além da proposta de expansão das esferas de cuidado através dos sentimentos de empatia, simpatia e responsabilidade.
Tradução do original "Note sur quand et comment Sartre a-t-il découvert Hegel?", de Vincent de Coorebyter
Authors: Pizelli Fabrício Rodrigues
Published: July 2024

Este texto, que integra os anais do Bulletin d’information du Groupe d’Études Sartriennes, de 1997, configura-se como uma imprescindível indicação bibliográfica e historiográfica sobre os primeiros contatos de Sartre com o pensamento hegeliano e quais foram suas leituras na recepção tardia do pensamento hegeliano na França. Desse modo, Coorebyter recorre não somente aos textos biográficos de Sartre, mas aos relatos biográficos de Simone de Beauvoir e às correspondências que se situam no período de desenvolvimento intelectual e redação da ontologia madura de 1943, L’être et le néant. Além disso, através das indicações bibliográficas realizadas por Coorebyter, é possível compreender melhor o teor da recepção francesa ao pensamento de Hegel, de modo a priorizar a Fenomenologia do Espírito em detrimento da Ciência da Lógica. Tal aspecto não escapa ao primeiro contato de Sartre com filosofia hegeliana, que por intermédio de Simone de Beauvoir, teve contato com a leitura de Kojève, pois não frequentou os cursos.
“Open It That You May Know Wonders”
Authors: López Martínez María Paz , López Olimpia Navarro
Published: July 2024

The reading of the series of die-cut stories Greek Stories on Papyri can help us to open us to express emotions and to better understand human nature. The collection comprises five volumes: The Adventures of Calligone and the Amazons; Ninus; The Adventures of the King of Nineveh; The Papyrus of the Sailor Sinuhe; and The Martyrdom of Saint Parthenope. Ninus is an Assyrian prince and the action begins in Mesopotamia. Calligone is the daughter of the king of Boristhenes and her ship is wrecked in the country of the Amazons. Sesoncosis is a Pharaoh who that travels to the Iberian Peninsula. Finally, Parthenope is the protagonist of a martyrdom. Both the texts and the illustrations on each page are based on data of a literary, historical, iconographic, and archaeological nature. By means of the corresponding adaptations, this documentation is made available to an audience from children to adults. It could be a tool for interactive, enjoyable and relaxed exchange of knowledge and experience between readers of different generations within the same family.
Simulation of urban sprawl and the analysis of the sustainability of developments using Cellular Automata and Remote-Sensing: Findings from Kurunegala, Sri Lanka
Authors: Hasan F. , Jayasinghe A. B.
Published: July 2024

Cellular Automata (CA) models are effective methods for simulating land use change. This research used CA to model the pattern of urban sprawl in the Kurunegala district in Sri Lanka, within the period from 2022 to 2027. The model was developed using land use land cover (LULC) data ranging from 2007 to 2022. Urban sprawl prediction models are extensively used in contemporary studies, with the majority of models emphasizing the technical components of modeling. However, most of these models do not assess their simulated results against the real development potential or any suggested development potential. The objective of this research is to simulate the urban sprawl in Kurunegala and compare the results with the assessment of development suitability, which will also be carried out using the zone factors assigned in the Urban Development Plans prepared by the UDA (Urban Development Authority) Kurunegala. According to the modeling findings, urban growth in Kurunegala will spread out during the next five years, covering an approximate area of 309.534 square kilometers by 2027. The simulation showed that the distribution of urban sprawl aligns with the suitability of the region for development, as established by the study done using the Arc Map model builder. Nevertheless, the forecast for the zone factor in 2030 does not completely align with the predicted outcomes.
Impact of Technology Readiness in Digital Banking Adoption and Role of Mediating Effect of Behavioral Intention: A Study of Commercial Banking Customers of Sri Lanka
Authors: Tennakoon Indika
Published: July 2024

The landscape of digital banking in Sri Lanka has rapidly changed in the last several years, with a wide range of financial institutions offering their clients online and mobile banking choices. Even though digital banking is becoming more popular, less is known about how it is used in underdeveloped nations like Sri Lanka. This study explores the influence of Tech-nology Readiness (TR) and the mediating effect of Behavioral Intention (BI) on Actual Us-age (AU) of digital banking services as it relates to Sri Lanka's adoption of digital banking. Online data collection from 172 users revealed that Sri Lankan commercial bank clients use digital banking at a medium level. Significantly, there is a positive relationship between Ac-tual Usage and Technology Readiness. When Behavioral Intention moderates the association between Technology Readiness and Actual Usage, Technology Readiness is no longer a reliable indicator of Actual Usage. Moreover, the results of the Sobel test indicate that Be-havioral Intention is not a substantial mediator of this association. Subsequent investigation, however, indicates that Behavioral Intention strongly moderates the link between Innova-tiveness (IN) and Actual Usage (AU) and Optimism (OP) and Actual Usage (AU) (i.e. Driv-ers). But Behavioral Intention is not a substantial mediator for Insecurity (IS) and Discom-fort (DI), i.e., Inhibitors. This study adds by offering evidence in a novel situation, and its findings broaden the body of knowledge by illuminating the factors that influence consum-ers' intentions to use digital banking.
Application of Industry 4.0 Technologies in Accounting Profession: Evidence from Sri Lanka
Authors: Dharmasena I. P. N. , Herath H. M. M. N. , Aruppla W. D. N.
Published: July 2024

The world of technology is rapidly changing and evolving. It has positive and negative consequences on every sector of the world, directly or indirectly. The aim of this paper is to examine the impact of Industry 4.0 technologies on accounting and auditing profession-als in Sri Lanka and the study examines the perception of professionals. The concept of Industry 4.0 can be identified as a synthesis of various technologies, including artificial intelligence, big data, cloud computing, and robotic process automation etc. This study fo-cuses on four major technological innovations and examines how the major technological changes in Industry 4.0 are affecting the accounting and auditing profession in Sri Lanka. These include artificial intelligence, big data, cloud computing, and robotics. Data was col-lected through a survey questionnaire which is shared among the professionals using an online survey method. A mean value analysis was conducted using SPSS analytical soft-ware. Findings of the study revealed that Industry 4.0 has a significant impact on the de-velopment of the accounting and auditing process and on the auditing and accounting pro-fession. In addition, the study reveals that accounting and auditing professionals need to develop their skills and competencies to work with new technologies. The researcher ex-pected that this will enable future accounting professionals to develop a keen interest in developing the skills and competencies they will need to successfully meet these chal-lenges.
Estimation of a Critical Gap/ Lag in Uncontrolled Intersections in Sri Lanka
Authors: Samarasekara G. N. , Perera K. S. S.
Published: July 2024

The critical gap/lag value for an uncontrolled intersection is an important parameter in estimating highway traffic capacity and developing micro stimulations of traffic movements. In manoeuvring an intersection, drivers decide to accept or reject the gap, based on several considerations. However, only a few studies have been carried out to estimate the critical gap on Sri Lankan roads; meanwhile, estimates of external factors are rare. This study found the influence of external factors on drivers’ gap acceptance decision and estimated the critical gap/ lag values using the Binary Logistic model. Analysis considered 4,233 gap acceptance decisions taken by drivers on minor roads. These were collected at three four-way and two three-way intersections and analysed across three vehicle categories: Motorcycle, Threewheeler, and Car/Van. Among the external factors studied, vehicle type, intersection type, size of the available gap, and type of traffic manoeuvre were found to have a significant influence on gap acceptance. Critical gap/lag values found in this study can be used for capacity estimation of three-way and four-way intersections in Sri Lanka.
Spontaneous rupture of a splenic artery pseudo-aneurysm post sleeve gastrectomy: case report
Authors: Taddei Filippo , Furlan Anna , Azzolini Valentina , Pitoni Federica , Paolillo Ciro
Published: July 2024

Pseudo-aneurysm of the splenic artery is a rare phenomenon in young males without risk factors and its rupture represents a true emergency. This condition is difficult to diagnose because the symptomatology is often blurred and not straight. Diagnosis should be as fast as possible to reduce patient mortality. With this case report we would like to report our experience of a successfully managed case of splenic artery pseudo-aneurysm rupture in a young man without risk factors and with a history of sleeve gastrectomy.
A dark and black esophagus
Authors: Scarilli Flavio , Tizzani Davide
Published: July 2024

A 70-year-old Italian man presented to our emergency department for dyspnea and confusion. He was affected by diabetes mellitus type 2, but he stopped his medication 10 years before. At admission, his vital signs were blood pressure of 60/50 mmHg, heart rate of 130 bpm, peripheral oxygen saturation of 94% in the Venturi Mask FiO2 40%, respiratory rate of 40/min, and body temperature of 36°C. Physical examination revealed hypoperfusion with a high Mottling Score and dark stools with a positive hydrogen peroxide reaction. He denied abdominal pain, nausea, and vomiting. Laboratory findings showed leucocytosis (White Blood Cells, WBC, 31,580/mm3; N 91.6%), Hemoglobin (Hb) 14.5 g/dL, Hematocrit Test (Hct) 49%, hyperglycaemia (>700 mg/L), and normal coagulation time. Arterial blood gas documented a metabolic acidosis with pH 6.95, Partial Pressure of Carbon Dioxide (pCO2) 27.5 mmHg, HCO3 7.1 mmol/L, lactate 8.14 mmol/L (normal value <2), and elevated anion gap metabolic. He was first treated with IV therapy as follows omeprazole 80 mg, tranexamic acid 1 g, Ringer acetate 1000 cc, sodium bicarbonate 8.4% 100 mg, and magnesium sulfate 2 g. Then, a continuous IV infusion of Ringer 150 mL/h and omeprazole 8 mg/h was started. An Esophagogastroduodenoscopy (EGD) was arranged and showed circumferential blackening of the distal half of the esophagus.
Holistic and Personalized Strategies for Managing in Elderly Type 2 Diabetes Patients
Authors: Yun Jae-Seung , Kim Kyuho , Ahn Yu-Bae , Han Kyungdo , Ko Seung-Hyun
Published: July 2024

Due to increased life expectancy and lifestyle changes, the prevalence of diabetes among the elderly in Korea is continuously rising, as is the associated public health burden. Diabetes management in elderly patients is complicated by age-related physiological changes, sarcopenia characterized by loss of muscle mass and function, comorbidities, and varying levels of functional, cognitive, and mobility abilities that lead to frailty. Moreover, elderly patients with diabetes frequently face multiple chronic conditions that elevate their risk of cardiovascular diseases, cancer, and mortality; they are also prone to complications such as hyperglycemic hyperosmolar state, diabetic ketoacidosis, and severe hypoglycemia. This review examines the characteristics of and management approaches for diabetes in the elderly, and advocates for a comprehensive yet personalized strategy.
Application of Support Vector Machine Classification Model to Identification of Vascular Endothelial Growth Factor Receptor Inhibitors
Authors: Arabi Nooshin , Torabi Mohammad Reza , Ghasemi Fahimeh
Published: July 2024

Background:

Nowadays, with the increasing prevalence of cancer mortality, finding the best cancer inhibitors is vital. Angiogenesis, which refers to the formation of new blood vessels from existing ones, undergoes abnormal changes in the physiological process of solid tumors. Vascular endothelial growth factor receptor (VEGFR) plays a crucial role in angiogenesis. Hence, one of the suggestions in cancer treatment has been inhibiting VEGFR signaling to prevent angiogenesis. The computational approach as an in vitro alternative method is crucial to reduce time and cost. This study aimed to use classification algorithm to separate potent inhibitors from inactive ones.

Materials and Methods:

In order to apply the machine learning model, biological compounds were extracted from the BindingDB database. Due to the large number of molecular features, the classification model was susceptible to overfitting. To address this issue, a correlation-based feature selection algorithm was proposed as a means of feature reduction. Subsequently, for the classification step, a support vector machine model that utilizes both linear and non-linear kernels was employed.

Results:

The implementation of the support vector machine model with the radial basis function kernel, along with the correlation-based feature selection method, resulted in a higher accuracy (81.8%, P value = 0.008) compared to other feature selection methods used in this study. Finally, two structures were introduced with the highest binding affinity to inhibit the second VEGFR.

Conclusion:

According to the results, the correlation-based feature selection method is more accurate than other methods.
Cytotoxic Effects of a Novel tagged Apoptin on Breast Cancer Cell Lines
Authors: Lakhshei Parisa , Ahangarzadeh Shahrzad , Yarian Fatemeh , Koochaki Ameneh , Kazemi Bahram , Kiamehr Zahra , Mohammadi Elmira , Alibakhshi Abbas
Published: July 2024

Backgrounds:

Apoptin can induce tumor cell-specific apoptosis in a broad range of human tumor cells and is a potential anticancer therapeutic candidate to kill tumor cells.

Materials and Methods:

We designed two structures of apoptin fusion protein, SUMO-PTD4-Apoptin, and PTD4-Apoptin. To express these fusion proteins, E. coli BL21(DE3) was employed. MTT assay, Flow cytometry, and cell cycle analysis were used to investigate the function of proteins on two breast cancer cell lines (MDA-MB-231 and MCF-7) and MCF 10A cell line (as normal cells).

Results:

Expression of the recombinant SUMO-PTD4-Apoptin and PTD4-Apoptin in E. coli BL21(DE3) was successful. MTT assay results showed that the IC50 was 6.4 µg/ml for SUMO-PTD4-Apoptin in MDA-MB-231 and was 9.3 after 24 h of treatment in MCF-7. The specific cytotoxicity in both cell lines is significant in comparison with MCF-10A, which is used as a normal cell line (IC50 = 29.4). The IC50 for PTD4-Apoptin was 11.07 µg/ml after 24 h of treatment in MDA-MB-231, while the IC50 of PTD4-Apoptin for MCF7 cells was not significantly different from normal cells. The flow cytometry analysis displayed a significant increment in the apoptosis and late apoptosis number in the MDA-MB-231 cells after treatment with SUMO-PTD4-Apoptin and PTD4-Apoptin protein. PTD4-Apoptin and SUMO-PTD4-Apoptin treatment of MDA-MB-231 cells caused a noteworthy increase in the G0-G1 phase and a reduction in the cell population of S and M/G2.

Conclusion:

This study demonstrates that the fusion of PTD4-Apoptin to SUMO-PTD4-Apoptin could provide an effective method to help enhance the expression and solubility of heterologous Apoptin in E. coli. BL21 (DE3).
A Survival Prediction Model of Self-Immolation Based on Machine Learning Techniques
Authors: Sadeghi Malihe , Bayati Baran , Kazemi Azar , Tajvidi Asr Rahime , Sayadi Mohammadjavad
Published: July 2024

Background:

Self-immolation is one of the violent methods of suicide in developing countries. Predicting the survival of self-immolation patients helps develop therapeutic strategies. Today, machine learning is widely used in diagnosing diseases and predicting the survival of patients. This study aims to provide a model to predict the survival of self-immolation patients using machine learning techniques.

Materials and Methods:

A retrospective cross-sectional study was conducted on 445 hospitalized self-immolated patients admitted to a burn hospital between March 2008 and 2019. Python programming language version 3.7 was used for this goal. All possible machine-learning algorithms were used. Gradient Boosting, support vector machine (SVM), random forest, multilayer perceptron (MLP), and k-nearest neighbors algorithm (KNN) were selected as the high-performance machine learning technique for survival prediction, and then they were compared by evaluation metrics such as F1 score, accuracy, sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC). Based on this comparison, the best model was reported.

Results:

SVM was the best algorithm. F1 score, accuracy, and AUC for this machine-learning model were 91.8%, 91.9%, and 0.96, respectively. The machine learning model results revealed that surgical procedures, score, length of stay, anatomical region, and gender obtained the most important and had more impact than other factors on patients’ survival prediction.

Conclusion:

In this paper, machine learning algorithms were used to create a model for survival of self-immolation patients. The results of this study can be used as a model for predicting self-immolation patients’ survival, better treatment management, and setting up policies and medical decision-making in burn centers.
Outcomes of Laparoscopic Approach to Cesarean Scar Pregnancy (CSP)
Authors: Rouholamin Safoura , Ghasemi Toudeshkchuei Nasrin , Hashemi Maryam , Allameh Zahra , Naghshineh Elham
Published: July 2024

Background:

Cesarean scar pregnancy (CSP) is a rare long-term complication after cesarean delivery. In clinical practice, its diagnosis and management is very important because it may be associated with serious consequences. Although a wide range of treatment options have been reported, the best treatment is unrecognized yet. This study aimed to evaluate the outcomes of laparoscopy in CSP.

Materials and Methods:

This non-randomized single-arm clinical trial was conducted on 43 CSP patients who were referred to the educational and medical centers of Isfahan University of Medical Science from 2021 to 2022. All the patients were treated by laparoscopy, and during follow-up, the pregnancy test was measured weekly until the test was negative, and an ultrasound was performed 6 months later. Myometrial thickness and occurrence of isthmocele were checked and recorded. Abnormal uterine bleeding or pelvic pain were also evaluated 6 months later.

Results:

Mean time of surgery was 55.12 ± 10.61 minutes, and the rate of intraoperative bleeding was 62.93 ± 24.00 cc. Four cases had excess intraoperative bleeding: two of them received packed cells, and two led to laparotomy. After surgery, the time to negative pregnancy test was 19.21 ± 5.50 days and 4 (10.3%) patients had isthmocele in follow-up sonography. Human chorionic gonadotropin hormone (BHCG) decreased significantly after surgery (percentage reduction: 97.71 ± 3.80; P value < 0.001) and myometrial thickness increased significantly (percentage increase: 46.94 ± 28.66; P value < 0.001).

Conclusion:

Laparoscopic excision of a CSP is an effective and feasible technique with the advantage of an immediate myometrial reconstruction.
Relative Frequency of Gastrointestinal Functional Disorders in Patients with Inflammatory Bowel Disease Based on Rome IV: A Case-Control Study
Authors: Soheilipour Maryam , Chermahini Tahereh Ghasemi , Tamizifar Babak , Kassaian Nazila , Khorasani Marzieh Rahim , Adibi Peyman
Published: July 2024

Background:

Inflammatory bowel disease (IBD) is a digestive system ailment that causes significant bodily disruption. This problem may coexist with other digestive system illnesses. One of the diseases that reduces the quality of life and other disorders is functional dyspepsia (FD), the diagnosis of which is associated with unique limitations. In this study, we aim to investigate the relative frequency of FD in IBD patients and compare it with a healthy control group.

Materials and Methods:

In a case-control study, we selected a group of IBD patients and healthy controls, and all participants were prepared for a diagnosis of FD symptoms using ROME IV criteria. Data were analyzed and compared using Chi-square and t-test, and P ≤ 0.05 was considered significant.

Results:

There were 100 IBD patients, including 91 with ulcerative colitis and 9 with Crohn’s disease (mean age, 41.37 ± 13; 39 males, 61 females). Furthermore, 100 healthy control subjects (mean age, 44.23 ± 14; 38 males, 62 females) were analyzed. 10% of IBD patients met the criteria of FD, which was comparable with the controls (5, 5%) (P > 0.05). Some of the symptoms of irritable bowel syndrome (IBS) including abdominal pain (P = 0.01) and bowel movement (P = 0.02) were significantly higher in IBD patients than in non-IBD subjects.

Conclusions:

The symptoms of FD were not significantly greater in IBD patients compared to the control group, while IBS symptoms were significantly higher in IBD individuals, indicating a possible overlap of Rome IV IBS and FD.
The Growth of A549 Cell Line is Inhibited by Pemetrexed Through Up-regulation of hsa-MiR-320a Expression
Authors: Ghorbani Alvanegh Akbar , Esmaeili Gouvarchin Ghaleh Hadi , Mohammad Ganji Shahla
Published: July 2024

Background:

Lung cancer deaths are increasing worldwide and the most common form of lung cancer treatment is chemotherapy. Pemetrexed (PMX) has been shown to be effective as a second-line treatment for advanced patients. Drugs can alter the expression of MicroRNAs, and MicroRNAs also can either enhance or reduce the drug’s effectiveness and this is a two-way relationship. Hsa-MiR-320a is known to play a crucial role in the lung cancer. This study aims to investigate the expression of hsa-MiR-320a in lung cancer cells after treatment with PMX.

Materials and Methods:

A549 cells were cultured and treated with varying concentrations of PMX. Various parameters were measured, including cell viability, reactive oxygen species (ROS) production, lactate dehydrogenase (LDH) release, apoptosis assay, caspase 3 and 7 enzyme activity, and scratch assay. Additionally, gene expression profiles of hsa-MiR-320a, VDAC1, STAT3, BAX, and BCL2 were evaluated.

Results:

PMX reduced the viability and increased apoptosis. After 48 h, ROS production was 3.366-fold higher than in control cells and the LDH release rate was increased by 39%. PMX also up-regulated the expression of hsa-MiR-320a by about 12-fold change.

Conclusion:

Changes in the expression of MicroRNAs occur after chemotherapy, and these changes play a crucial role in regulating the growth of cancer cells. Identifying these MicroRNAs can be helpful in predicting the efficacy of the chemotherapy or introducing it as combination therapy. Our research has been shown that hsa-MiR-320a can serve as a biomarker of PMX efficacy and also has the potential to be used in combination therapy.
Enhancing the Antioxidant Activity of Alginic Acid Extracted from Sargassum Angustifolium Brown Algae Based on Optimizing the Extraction
Authors: Kolahdoozan Melika , Mousavi Seyed Erfan , Hatamipour Mohammad Sadegh , Yegdaneh Afsaneh
Published: July 2024

Background:

Researchers are always searching for chemicals with antioxidant properties. The cell wall polysaccharide of Sargassum angustifolium consists of alginic acid. To use this polysaccharide and investigate on its various effects, it must first be isolated from brown algae and the operational parameters of extraction need to be optimized to reach the maximum antioxidant effect.

Materials and Methods:

The effects of changing the parameters (temperature, time, and power of ultrasonic waves) used in the extraction of alginic acid were discussed based on changes in the antioxidant effect. After that, M/G (β-D-mannuronic acid to α-L-guluronic acid ratio) was measured using 1H NMR spectra, and the antioxidant activity of the extracted alginic acid was examined using the DPPH method.

Results:

The highest antioxidant effect was observed in sample No. 4 with an extraction temperature of 65°C, extraction duration of 25 min, and 640 W of ultrasonication power, whereas the lowest antioxidant effect was observed in sample No. 7 at 45°C, 20 min, and 480 W.

Conclusion:

Structural changes due to increasing temperature may cause less activity, whereas the optimum temperature was 65°C. There was no direct relationship between M/G and IC50, and it should be examined along with molecular weight. Increasing the intensity of the waves increased the antioxidant activity. The extraction yield can be increased by increasing A/W (Gram of algal sample per mL of solvent). It appears that the extraction under optimum conditions enhances the MM block epimer, which may lead to an increase in the antioxidant activity.
Evaluation of the effect of atorvastatin on corneal endothelial cells during the initial 12-month period after acute coronary syndrome
Authors: Karapapak Murat , Demirtola İrem , Kelebek Merve , Ozal Ece , Ermis Serhat , Ozal Sadik
Published: July 2024

Purpose:

It was aimed to compare corneal endothelial changes during the initial 12-month period in which patients started using atorvastatin after a diagnosis of acute coronary syndrome (ACS).

Methods:

Forty-six participants (group 1) who underwent cardiac angioplasty and stenting for ACS and started using 80 mg atorvastatin in the early period were included in the study. In the study, a control group comprising 71 healthy adults (group 2) was included. These individuals did not use medication for any known systemic disease, had never taken statins, had no history of ocular surgery, and did not have any cornea-related eye diseases. Baseline and 12th month endothelial evaluations of group 1 and 2 participants were compared using specular microscopy.

Results:

There were 28 female and 18 male participants in group 1 and 48 female and 23 male participants in group 2 (P = 0.455). The mean baseline corneal endothelial cell density (CECD) was not significantly higher in group 1 compared to group 2 (2471.4 ± 200 cells/mm2 vs 2428.2 ± 539.8 cells/mm2, P = 0.230). When the change between baseline and 12th month CECD was examined, the decrease in group 2 was significantly different from that in group 1 (-15,2 ± 31,9 and -44,8 ± 49,6, P = 0,002). Although the percentage of hexagonal cells decreased significantly in group 2 participants, no significant change was observed in group 1 (respectively; P < 0.001, P = 0.073). The endothelial cell coefficient of variation did not differ significantly in group 1 participants over a 1-year period (P = 0.192), and a significant increase was observed in group 2 (P < 0.001).

Conclusion:

This study revealed that atorvastatin may have a positive effect on corneal endothelium cell density and morphology.
Evaluation of accuracy for prediction of soft tissue profile changes in non-growing patients undergoing orthodontic treatment using cephalometric android application.
Authors: Shah Rushabh , Durkar Sachin , Deshmukh Sonali , Rahalkar Jayesh
Published: July 2024

INTRODUCTION: An accurate prediction in soft tissue changes is of great importance for orthodontic treatment planning. Patients find it difficult to imagine how their facial appearance may change after orthodontic treatment without a visual reference. Predicting the postoperative facial appearance may thus be useful for managing expectations, easing communication, and researching different treatment choices. Computer-assisted programs are still relatively expensive and are not portable in comparison to smartphones, and the accuracy of soft tissue profile prediction of these android applications has not been thoroughly assessed. The purpose of the study is to assess how well the Webceph cephalometric Android application predicts changes in soft tissue profile following orthodontic treatment.MATERIALS AND METHOD: A total of 50 patients were screened for eligibility, and 24 young adult patients (8 males, 16 females; mean age 24.8 ±3.9 years) were finally included in the study based on the inclusion and exclusion criteria. The landmarks and parameters of the Legan and Burstone soft tissue analysis were used for the cephalometric analyses. The cephalometric tracings of the actual treatment result and the Webceph predicted treatment outcome was superimposed to calculate the prediction errors. Paired t-test used to compare the statistical differences between the predicted and actual treatment outcomes of the parameters used in the legan and burstone soft tissue analysis.RESULTS: There were significant differences between the predicted and actual values in parameters of legan and burstone soft tissue analysis (P\0.05). It was reported that the prediction in two parameters (i.e., Lower face throat (Sn-Gn-C angle) (Cm-sn-ls) Nasolabial angle) was a significant difference from the actual modifications in class I bimaxillary protrusion group and there were substantial changes in the prediction of two characteristics (facial convexity (G-Sn-Pg angle) and inter labial (Stms-Stmi) in the class II group.CONCLUSIONS: The Webceph VTO prediction in soft tissue changes after the orthodontic treatment in patients with bimaxillary protrusion and class II malocclusion is the most accurate for the nasolabial angle and the least accurate for the mandibular prognathism parameter.
Quasi-countable inverse semigroups as metric spaces, and the uniform Roe algebras of locally finite inverse semigroups
Authors: Chung Yeong Chyuan , Martínez Diego , Szakács Nóra
Published: July 2024

Given any quasi-countable, in particular, any countable inverse semigroup

S

, we introduce a way to equip

S

with a proper and right subinvariant extended metric. This generalizes the notion of proper, right invariant metrics for discrete countable groups. Such a metric is shown to be unique up to bijective coarse equivalence of the semigroup, and hence depends essentially only on 

S

. This allows us to unambiguously define the uniform Roe algebra of

S

, which we prove can be realized as a canonical crossed product of

\ell^{\infty}(S)

and

S

. We relate these metrics to the analogous metrics on Hausdorff étale groupoids. Using this setting, we study those inverse semigroups with asymptotic dimension

0

. Generalizing results known for groups, we show that these are precisely the locally finite inverse semigroups and are further characterized by having strongly quasi-diagonal uniform Roe algebras. We show that, unlike in the group case, having a finite uniform Roe algebra is strictly weaker and is characterized by

S

being locally

\mathcal{L}

-finite, and equivalently sparse as a metric space.
A Report on the International Conference Ethical Dilemmas in Ethnographic Field Research
Authors: Ivnik Tina , Hamer Petra
Published: July 2024

On 25 January 2024, Tina Ivnik and Petra Hamer organised an international conference entitled Ethical Dilemmas in Ethnographic Research as one of the events of the ERC project DEAGENCY (№ 101095729). The hybrid conference took place at the Department of Ethnology and Cultural Anthropology University of Ljubljana and was simultaneously transmitted on Zoom. Twelve presenters talked about the different aspects of ethical dilemmas they have personally faced while conducting fieldwork. The idea for the conference arose from the need to discuss ethical dilemmas more profoundly, exchange ideas and thoughts, provide support and share advice with colleagues and co-workers, who have all experienced different situations in the field.
Uvodnik
Authors: Račič Manca , Uhrin Michal
Published: July 2024

Religija je že desetletja v središču pozornosti antropologov, etnologov in verskih učenjakov. Teorije o religiji, obredih in magiji so med drugim zasnovali ugledni učenjaki, kot so Émile Durkheim, William James, Marcel Mauss, Bronislaw Kasper Malinowski, Clifford Geertz in Victor Witter Turner. Religija, magija in rituali skupaj s sorodstvenimi in družinskimi odnosi, odnosi med spoloma, političnimi sistemi, kmetijstvom in načini proizvodnje ter raznolikimi manifestacijami ljudske kulture sodijo med klasična raziskovalna področja etnologije in sociokulturne antropologije. Čeprav so minila desetletja od objave klasičnih del, religija ostaja ključno področje raziskovanja. Klasične teme, kot so obredi, magija in nadnaravno škodovanje, so še vedno privlačne za sodobne učenjake, tudi če jih gledamo z novih teoretičnih in metodoloških perspektiv. Zadnja desetletja pa so prinesla tudi nove raziskovalne teme v empiričnem smislu, kot sta religija v spletnem prostoru ali religija v postmodernem in globaliziranem svetu. Te spremembe odražajo tudi prispevki v dvojni številki Svetov 2024. Medtem ko prva številka prinaša prispevke, ki temeljijo na različnih vrstah empiričnih, etnografskih ali zgodovinskih podatkov, povezanih s srednjeevropskim kontekstom (Češka, Slovaška, Madžarska ) in Japonsko, je druga posvečena teoretskim, metodološkim in epistemološkim vidikom akademskega študija religije.
Ritual: How Seemingly Senseless Acts Make Life Worth Living, by Dimitris Xygalatas
Authors: Uhrin Michal
Published: July 2024

Dimitris Xygalatas is an anthropologist and cognitive scientist interested in religion, ritual, music, and sports fanship among other topics. Xygalatas’s book Ritual: How Seemingly Senseless Acts Make Life Worth Living (Profile Books, 2022; henceforth Ritual) results from years of rigorous ethnographic and experimental work. Ritual follows the perspective of the cognitive and evolutionary science of religion (hereafter referred to as CESR) and brings the reader up-to-date findings in the naturalistic study of religion and rituals. Xygalatas follows a neo-Darwinian and functionalistic approach to the study of religion, whose theoretical premises he describes in a way that is accessible even to the lay public throughout the book, but mainly in its second chapter.
Crónicas y reflexiones de un Epidemiólogo de campo. Luchando contra los brotes de Cólera para la Equidad en la Salud Global
Authors: Parisi Andrea , Estévez-Reboredo Rosa Maria
Published: July 2024

Las actividades de un epidemiólogo de campo siempre son enriquecedoras como muestra el trabajo llevado a cabo en el último año en dos países en vías de desarrollo del continente Africano afectados durante varios brotes de cólera; en los que se pudo experimentar de primera mano el efecto devastador de una enfermedad, que rara vez se observa en países industrializados en la actualidad.
Con esta reflexión se trata de visibilizar y poner en valor el trabajo de campo, proporcionar ideas sobre las actividades de un epidemiólogo ante brotes de cólera, mostrar los grandes desafíos para realizar un abordaje rápido y eficaz con los medios disponibles.
Ventilação mecânica invasiva em neonatos pós-termo com síndrome de aspiração de mecônio: uma revisão integrativa
Authors: Lobato Danielly Gomes , Soares Enathanael Ribeiro , Xavier Flávio Vinícius Fagundes , Assis Juvêncio César Lima de , Oliveira Rayane Sales de , Cardoso Glêbia Alexa , Feitosa Rafaela Macêdo , Arrais Joel Freires de Alencar
Published: July 2024

A Síndrome de Aspiração de Mecônio (SAM) é uma condição clínica que afeta neonatos expostos ao líquido amniótico contendo mecônio. Essa situação pode resultar em complicações respiratórias sérias, levando à insuficiência respiratória. O uso de oxigênio e/ou Ventilação Mecânica Invasiva (VMI) são tratamentos cruciais para neonatos com problemas respiratórios. O objetivo do estudo é identificar os impactos da VMI em neonatos nascidos a termo com SAM. Trata-se de uma revisão integrativa, realizada em cinco bases de dados eletrônicas: SciELO, ScienceDirect, LILACS, MEDLINE e PubMed. Foram considerados estudos publicados entre 2013 e 2023 em inglês e em português, com métodos de intervenção em neonatos nascidos a termo, de ambos os sexos, de qualquer etnia, que tenham sido submetidos à ventilação mecânica. Quatro estudos foram escolhidos, totalizando 204 participantes com idade gestacional média entre 37,4 e 40,16 semanas. Os profissionais empregaram métodos ventilatórios básicos e avançados no tratamento da disfunção respiratória, juntamente com a utilização de gás Hélio. Foi notada melhora na oxigenação e uma redução no tempo de ventilação mecânica. É evidente a eficácia positiva da VMI na melhoria da oxigenação, especialmente quando combinada com outras estratégias, como o uso de gás Hélio, o que pode resultar em menor tempo de ventilação. Isso destaca a importância das estratégias ventilatórias na proteção pulmonar desses neonatos.
Relationship between Urogenital Culture Positivity and Threatened Preterm Labor in Pregnant Women
Authors: Firat Aysun , Katlan Doruk Cevdi , Uzunay Nebahat
Published: July 2024

Purpose: Threatened preterm labor (TPL) resulting in preterm delivery is known to be one of the leading causes of adverse pregnancy outcomes and neonatal morbidity. In the current study, we evaluated patients with TPL to understand the probable association between positive urogenital culture and preterm labor.
Materials and Methods: Medical records of patients who were admitted for TPL between 2018 and 2022 were reviewed. Demographics, gestational history and culture results of both vaginal swabs and urine samples were recorded. Transvaginal ultrasonographic (TVUS) measurement of cervical lengths were performed during preterm or term delivery, and graded as
Serverless Computing en el campo de la Ciberseguridad. Una revisión sistemática de literatura
Authors: Pacheco Armijos Ximena del Carmen , Quevedo Sacoto Andrés Sebastián
Published: July 2024

En la última década, Serverless Computing ha emergido como una revolución en la forma en que se desarrollan y despliegan aplicaciones, permitiendo a los desarrolladores centrarse exclusivamente en la lógica de sus aplicaciones y delegando la gestión de la infraestructura a proveedores de servicios en la nube. Es por ello, que la adopción de Serverless Computing ha crecido rápidamente debido a sus ventajas en términos de escalabilidad, costo y simplicidad operativa. Sin embargo, como cualquier tecnología emergente, el modelo sin servidor introduce nuevas vulnerabilidades y amenazas de seguridad que deben ser abordadas para garantizar la protección de los datos y la integridad de las aplicaciones. En el presente documento, se lleva a cabo una revisión sistemática acerca de serveless computing en el ámbito de la ciberseguridad, para analizar e identificar los desafíos y amenazas a los que se enfrentan los entornos serverless, así como sus beneficios y las soluciones propuestas para abordar estos desafíos. Los resultados de la revisión ofrecen el estado actual de la ciberseguridad en entornos de computación sin servidor.
Climate Change and its Impacts across Pakistan
Authors: Sarfaraz Sardar , Faisal Nadeem
Published: July 2024

Climate change and variability is best manifested by persistent global temperature rise, changing precipitationpatterns, increasing frequency of extreme weather events, rapidly shrinking ice sheets & glacier melting and sea-levelrise. This study analyzed the rainfall (for three major seasons; monsoon, winter & spring), temperature (in three indices;annual mean, annual daytime and annual nighttime temperatures) and extreme events recorded at 56 data sites acrossPakistan over 63-years period (1961-2023) to investigate the climate change and diagnose the trends. We did time-seriesanalysis to assess the annual variability and applied the Mann-Kendall statistical trend test to determine the trend’ssignificance. Results showed a significant rise in annual-average temperature, annual maximum as well as annualminimum temperatures all over Pakistan and at 27 stations individually, annual maximum temperature at 28 and annualminimum at 25 stations across Pakistan. In rainfall, the annual and spring (AMJ) rains have shown significant rising trendthroughout Pakistan, while, the summer monsoon (JAS) rainfall showed a statistically significant increase at 8 stationsin the north with decrease at 2 sites in southwest, winter (DJFM) rainfall witnessed an increase at 3 sites and so was thespring (AMJ) at 7 sites mostly in the south, while a decrease at 3 sites in north of the country (all changes being significantat 95- 99% CI). Extreme events include an increase in annual high-temperature extreme (Tmax > 35 °C), decrease inannual cool nights (Tmin < 10 °C) and increase in wet days. The snowfall has decreased in both amount and frequency ofsnow days in KP, GB and Punjab hilly station, Murree. There is an increasing frequency of cyclone formation in theArabian Sea, particularly the intensity being significant. Sea-level data analysis depicted a 2.02 mm/year sea-level rise atKarachi coast. Increased cyclones frequency coupled with potentially heightened storm surges and sea-level rise mayprove fatal to coastal areas
MOTHER AND FATHER FIGURATIVE EXPRESSIONS IN ENGLISH, RUSSIAN, AND HEBREW
Authors: Kigel Tali
Published: July 2024

The paper conducts a lingua-cultural analysis of figurative speech, focusing on idioms, metaphors, proverbs, and sayings that include the words mother/mom and father/dad in English, Russian, and Hebrew. The aim is to explore the concepts of mother and father in these languages. The study resulted in the compilation of tables and statistical data, covering approximately 205 expressions—100 in English, 65 in Russian, and 40 in Hebrew. The research employs descriptive, interpretive, and conceptual methods, as well as an analysis of dictionary definitions. The article delves into several key areas. It examines the quantitative relationship between expressions related to mothers and fathers, highlighting the unique role of parents, particularly mothers, in an individual's life. The study also explores expressions of unconditional and sometimes uncritical maternal love, alongside criticisms of overprotective maternal care in adulthood. Furthermore, it investigates differences in the portrayal of the mother's primary role across the three linguistic cultures and the interchangeability of gender in expressions. In addition, the paper discusses the use of humor, emotional exclamations, and curses involving the word mother as an intensifier, as well as variations in profanity with this word. The sources of these expressions include folk wisdom, Latin sayings, the Tanakh, the Old Testament, and quotes from literary and public figures.
 

 Article visualizations: