bluuebunny/crossref_metadata_2025 huggingface dataset:
Emotion Classification Method of Financial News Based on Artificial Intelligence
Authors: Li JieYing , Zheng ChenXi
Published: August 2022

With the continuous development of economy, the economic development model is constantly changing. Especially since China’s entry into WTO, the scale of economic development has reached a new height. The continuous development of economy makes the financial news module evolve towards specialization. However, with the emergence of Internet of Things technology, a large number of data appear in the network, which brings some difficulties to the classification and analysis of data economy. Emotion classification refers to the complexity and diversity of people’s emotions. It can be classified from different observation angles. Because the core content of emotion is value, human emotion should be classified mainly according to the different characteristics of the movement and change of value relationship it reflects. This paper is aimed at studying the emotional classification method of financial news based on artificial intelligence and expecting to use artificial intelligence technology and classification method to classify financial news. It allows more people to know the implied information of financial information and promotes economic development. Artificial intelligence is a branch of computer science. It attempts to understand the essence of intelligence and produce a new intelligent machine that can respond in a similar way to human intelligence. This paper mainly summarizes the topic selection characteristics and subdivision topic selection characteristics of financial data news through quantitative and qualitative methods and explores the classification of financial news. In this paper, a simplified classification algorithm based on convolution function is proposed for the classification of traditional financial news networks. The experimental results show that the classification accuracy of artificial intelligence method is improved by 4% compared with the traditional emotion classification method, and the classification accuracy of positive emotion is lower than that of negative emotion by 2%.
The Restricted Six-Body Problem with Stable Equilibrium Points and a Rhomboidal Configuration
Authors: Siddique M. A. R. , Kashif A. R.
Published: August 2022

We explore the central configuration of the rhomboidal restricted six-body problem in Newtonian gravity, which has four primaries

m

i

(where

i
=
1
,
…
4

) at the vertices of the rhombus

a
,
0

,

−
a
,
0

,

0
,
b

, and

0
,
−
b

, respectively, and a fifth mass

m

0

is at the point of intersection of the diagonals of the rhombus, which is placed at the center of the coordinate system (i.e., at the origin

0,0

). The primaries at the rhombus’s opposite vertices are assumed to be equal, that is,

m

1

=

m

2

=
m

and

m

3

=

m

4

=

m
˜

. After writing equations of motion, we express

m

0

,
m

, and

m
˜

in terms of mass parameters

a

and

b

. Finally, we find the bounds on

a

and

b

for positive masses. In the second part of this article, we investigate the motion and different features of a test particle (sixth body

m

5

) with infinitesimal mass that moves under the gravitational effect of the five primaries in the rhomboidal configuration. All four cases have 16, 12, 20, and 12 equilibrium points, with case-I, case-II, and case-III having stable equilibrium points. A significant shift in the position and the number of equilibrium points was found in four cases with the variations of mass parameters

a

and

b

. The regions for the possible motion of test particles have been discovered. It has also been observed that as the Jacobian constant

C

increases, the permissible region of motion expands. We also have numerically verified the linear stability analysis for different cases, which shows the presence of stable equilibrium points.
Sex Differences in the Relation between Comorbidities and Prognosis in Hospitalized Patients with COVID-19
Authors: Mohammadifard Noushin , Haghighatdoost Fahimeh , Nasirian Maryam , Zakeri Parisa , Heidari Kamal , Haghjooy Javanmard Shaghayegh , Sarrafzadegan Nizal
Published: August 2022

Purpose. There is a lack of information of the difference in sex-aggregated prevalence of comorbid noncommunicable disease (NCD) in patients hospitalized with COVID-19 in Iran. This study aimed to evaluate sex differences in the relation between medical comorbidities and subsequent death in patients hospitalized with COVID-19. Methods. All subsequently hospitalized patients with a diagnosis of moderate to severe COVID-19 since February 19th to June 14th, 2020, in Isfahan, Iran, were recruited in the ongoing I-CORE Registry. Real-time reverse-transcription polymerase chain reaction (RT-PCR) testing was done upon admission. Data on preexisting comorbid NCDs including hypertension, coronary heart disease (CHD), diabetes mellitus (DM), cancers, chronic renal disease (CRD), and chronic respiratory disease were collected through self-reported questionnaires. Results. Overall, 12,620 individuals were enrolled in this registry of which 4,356 were positive for the COVID-19 RT-PCR test. In the whole population, in women, DM, hypertension, and CHD, and in men, DM, CHD, and hypertension were, respectively, the most frequent comorbidities. The frequency of at least one NCD did not differ between men and women, but a greater proportion of women had two or more NCDs. Increasing the number of comorbidities was associated with higher death frequency and mortality risk in the unadjusted model but remained no longer significant after adjustment for age. There was no statistically significant difference in this regard between men and women. Conclusion. Overall, we found that DM, hypertension, and CHD were the most frequent comorbidities. Although comorbidities were more frequent among women, mortality risk did not significantly differ between men and women.
Meta-Analysis of the Effects of Recombinant Human Brain Natriuretic Peptides on Left Ventricular Remodeling in Patients with Acute Myocardial Infarction
Authors: Zhu Ping
Published: August 2022

Objective. Systematic evaluation of the efficacy of natriuretic recombination in human brain on disease myocardial infarction, left ventricular heart failure, and the efficacy and safety of long-term left ventricular remodeling. Methods. Computerized search of CNKI, Wanfang database, Wipro Chinese Technology Publications (VIP) numerical database, Chinese Biomedical Literature Database (CBM), Medline Cochrane Library, clinical Trail.Gov clinical collection, and other documents. Randomized controlled trials (RCT) of recombinant human brain natriuretic peptide in the treatment of acute myocardial infarction from inception to December 2021 were searched. Based on the Jadad scale, inclusion-exclusion data for diseases were collected and elaborated by meta by RevMan 5.3 simulation software. In a total of 23 randomized controlled trials, 2 024 cases were used as the basic data, the control group was routinely treated for 1 012 cases, and 1 012 cases in the experimental group were also treated with natriuretic peptide in the recombinant human brain on the previous basis. Results. In terms of overall efficacy, the experimental group was better than the control group, statistically significant (

OR
=
4.30

, 95% CI (3.26, 5.67),

P
<
0.000
 
01

), left ventricular ejection fraction in the experimental group than the control group (

OR
=
1.58

, 95% CI (1.27, 1.90),

P
<
0.000
 
01

). In terms of a myocardial strain in the left ventricle, the experimental group was superior to the control group. The difference was significant (

OR
=
−
0.91

, 95% CI (-1.50, -0.33),

P
=
0.002

). In terms of the cardiac output volume, the experimental group was superior to the control group (

OR
=
1.24

, 95% CI (0.55, 1.94),

P
=
0.0005

). Regarding brain natriuretic peptide precursors, the experimental group was superior to the control group (

OR
=
−
4.37

, 95% CI (-6.21, -3.25),

P
<
0.00001

). In terms of the heart rate, the experimental group was superior to the control group. Measurement of differential significance is as follows:

OR
=
−
13.70

, 95% CI (-14.95, -12.46),

P
<
0.00001

. In terms of contraction, the experimental group was superior to the comparison group (

OR
=
−
12.38

, 95% CI (-17.98, -6.79),

P
<
0.00001

). The experimental group outperformed the control group (

OR
=
−
7.42

, 95% CI (-8.53, -6.30),

P
<
0.00001

). In terms of bad influence, the measurement is as follows:

OR
=
0.95

, 95% CI (0.29, 3.16),

P
=
0.94

. Conclusion. In patients with acute myocardial infarction and left ventricular remodeling, if treated with a heavy treatment of the group of cerebral natriuretic peptide mode, it can increase clinical treatment, improve the cardiac effect, inhibit ventricular remodeling, improve blood pressure and heart rhythm, and have greater clinical treatment and safety.
Early Warning of Infectious Diseases in Hospitals Based on Multi-Self-Regression Deep Neural Network
Authors: Wang Mengying , Lee Cuixia , Wang Wei , Yang Yingyun , Yang Cheng
Published: August 2022

Objective. Infectious diseases usually spread rapidly. This study aims to develop a model that can provide fine-grained early warnings of infectious diseases using real hospital data combined with disease transmission characteristics, weather, and other multi-source data. Methods. Based on daily data reported for infectious diseases collected from several large general hospitals in China between 2012 and 2020, seven common infectious diseases in medical institutions were screened and a multi self-regression deep (MSRD) neural network was constructed. Using a recurrent neural network as the basic structure, the model can effectively model the epidemiological trend of infectious diseases by considering the current influencing conditions while taking into account the historical development characteristics in time-series data. The fitting and prediction accuracy of the model were evaluated using mean absolute error (MAE) and root mean squared error. Results. The proposed approach is significantly better than the existing infectious disease dynamics model, susceptible-exposed-infected-removed (SEIR), as it addresses the concerns of difficult-to-obtain quantitative data such as latent population, overfitting of long time series, and considering only a single series of the number of sick people without considering the epidemiological characteristics of infectious diseases. We also compare certain machine learning methods in this study. Experimental results demonstrate that the proposed approach achieves an MAE of 0.6928 and 1.3782 for hand, foot, and mouth disease and influenza, respectively. Conclusion. The MRSD-based infectious disease prediction model proposed in this paper can provide daily and instantaneous updates and accurate predictions for epidemic trends.
Analysis of Sports Popular Trend Based on Public Opinion Mining of New Media
Authors: Xie Qingtuan , Han Qing , Chen Dong
Published: August 2022

As an important means of communication, sports public opinion has been paid more and more attention by the country. This article will focus on the emergency events of sports events as the main object and research and analysis of the communication function and law in the public opinion of sports events and analyzes the characteristics of public opinion communication. This paper holds that the media play the “should be” roles in different periods, such as network public opinion monitoring and early warning, public opinion information processing and interpretation, consensus builder highlighting the mainstream, and introspection of public opinion events, and there is a media role cycle in the secondary public opinion period. Spreading law of public opinion in sports events in China: trigger-conduction-outbreak mechanism. At present, the diversified interactive mode of sports events in China makes the communication environment of public opinion in sports events more and more three-dimensional and multidimensional, and it is also convenient for us to make better use of the current regulation means of public opinion in sports events. Sports network public opinion can easily go to “post-truth.” In order to strengthen the monitoring of sports public opinion and improve the ability to respond to network public opinion, using interdisciplinary thinking, this paper proposes a network public opinion guidance strategy for sports events. The experiment is aimed at the disadvantage that the trend of sports public opinion analysis and tracking is not clear. The optimization method is proposed, and the accuracy is improved by 87.5%.
Synthesized 18-Lead Electrocardiogram in Diagnosing Posterior Stemi-Equivalent Acute Coronary Syndrome in Patients with NSTEMI
Authors: Horie Tomoki , Hamaya Rikuta , Sugiyama Tomoyo , Hirano Hidenori , Hoshino Masahiro , Kanaji Yoshihisa , Lee Tetsumin , Yonetsu Taishi , Sasano Tetsuo , Kakuta Tsunekazu
Published: August 2022

Objective. To assess the clinical utility of synthesized V7–V9 ST-segment elevation (sV7-9 STE) in patients with 12-lead-electrocardiogram (ECG)-based non-STE myocardial infarction (NSTEMI) in diagnosing left circumflex artery (LCx) STEMI-equivalent acute coronary syndrome (ACS). Background. The 12-lead-ECG is insufficient for diagnosing patients with ACS, especially those with an LCx culprit. Methods. We retrospectively examined 219 patients with NSTEMI who underwent synthesized 18-lead ECG acquisition on admission and urgent catheterization. Associations between baseline variables, including sV7-9 STE and LCx STEMI-equivalent ACS, were analyzed using logistic regression models and receiver operating characteristics. LCx-culprit ACS was defined as thrombolysis in myocardial infarction (TIMI) 0–1 flow. The association between sV7-9 STE and myocardial damage was also assessed. Results. The mean (SD) age of the population was 68.8 (12.0) years, and 81.7% were men. LCx-culprit NSTEMI occurred in 58 (26.5%) patients and 15 (6.8%) were LCx STEMI-equivalent. SV7-9 STE was observed in 16 patients (7.9%). SV7-9 STE was the sole significant predictor of LCx STEMI-equivalent ACS with an odds ratio of 19.0 (95% CI: 5.6–63.9,

p
<
0.001

), area under the curve of 0.71 (95% CI: 0.58–0.84), sensitivity of 46.7%, and specificity of 95.6%. After adjustment for confounders, sV7-9 STE was significantly associated with a 308% (95% CI: 78–834%) increase in peak high-sensitivity cardiac troponin I (

p
=
0.001

). Conclusions. SV7-9 STE had sole preprocedural diagnostic utility in detecting LCx STEMI-equivalent ACS with greater myocardial damage among patients with 12 ECG-based NSTEMI. The use of synthesized extra leads on admission may help identify patients with NSTEMI requiring primary revascularization.
Neutrophil Transcriptional Deregulation by the Periodontal Pathogen Fusobacterium nucleatum in Gastric Cancer: A Bioinformatic Study
Authors: Zhou Ting , Meng Xianhong , Wang Daxiu , Fu Weiran , Li Xinrui
Published: August 2022

Background. Infection with the periodontal pathogen Fusobacterium nucleatum (F. nucleatum) has been associated with gastric cancer. The present study is aimed at uncovering the putative biological mechanisms underlying effects of F. nucleatum–mediated neutrophil transcriptional deregulation in gastric cancer. Materials and Methods. A gene expression dataset pertaining to F. nucleatum-infected human neutrophils was utilized to identify differentially expressed genes (DEGs) using the GEO2R tool. Candidate genes associated with gastric cancer were sourced from the “Candidate Cancer Gene Database” (CCGD). Overlapping genes among these were identified as link genes. Functional profiling of the link genes was performed using “g:Profiler” tool to identify enriched Gene Ontology (GO) terms, pathways, miRNAs, transcription factors, and human phenotype ontology terms. Protein-protein interaction (PPI) network was constructed for the link genes using the “STRING” tool, hub nodes were identified as key candidate genes, and functionally enriched terms were determined. Results. The gene expression dataset GEO20151 was downloaded, and 589 DEGs were identified through differential analysis. 886 candidate gastric cancer genes were identified in the CGGD database. Among these, 36 overlapping genes were identified as the link genes. Enriched GO terms included molecular function “enzyme building,” biological process “protein folding,’” cellular components related to membrane-bound organelles, transcription factors ER71 and Sp1, miRNAs miR580 and miR155, and several human phenotype ontology terms including squamous epithelium of esophagus. The PPI network contained 36 nodes and 53 edges, where the top nodes included PH4 and CANX, and functional terms related to intracellular membrane trafficking were enriched. Conclusion. F nucleatum-induced neutrophil transcriptional activation may be implicated in gastric cancer via several candidate genes including DNAJB1, EHD1, IER2, CANX, and PH4B. Functional analysis revealed membrane-bound organelle dysfunction, intracellular trafficking, transcription factors ER71 and Sp1, and miRNAs miR580 and miR155 as other candidate mechanisms, which should be investigated in experimental studies.
Kinodynamic Trajectory Optimization of Dual-Arm Space Robot for Stabilizing a Tumbling Target
Authors: Yan Lei , Yuan Han , Xu Wenfu , Hu Zhonghua , Liang Bin
Published: August 2022

Capturing and stabilizing tumbling targets using dual-arm space robots are very crucial to on-orbit servicing task. However, it is still very challenging due to the complex dynamics coupling and closed-chain constraints between the manipulators, the base, and the target. In this paper, a kinodynamic trajectory optimization method is proposed to generate the motion of a dual-arm space robot for stabilizing the captured tumbling target, which is formulated and solved as a nonlinear programming problem using direct collocation. Instead of optimizing the trajectory of each joint with the dynamics model of space robot, this method optimizes the trajectory of the tumbling target while considering the kinematics and dynamics constraints between the two arms and the target simultaneously. The objective function of the optimization is defined as weighted detumbling time, base disturbance, and manipulability, in order to avoid singularity and save the energy of space robot for further manipulation. Several physical simulations are carried out to validate the proposed method.
Research on Reconfiguration of Distribution Network considering Three-Phase Unbalance
Authors: Wang Xuejie , Ji Yanchao , Wang Jianze , Zhao Yi , Ye Peng , Qi Lei , Yang Shuo , Liu Siqi
Published: August 2022

In the distribution network, the addition of distributed power sources can improve the voltage part of the distribution system, provide uninterrupted power supply, and reduce network losses. The location of the power supply and its output will also directly affect the system voltage and power loss. Therefore, determining the optimal installation location and capacity of distributed power generation is of great significance to the distribution network. However, in the actual system, due to the unbalanced load distribution and the three-phase unbalance of the transmission line, the power distribution system presents the characteristics of unbalanced distribution. As the number of electric vehicles increasing, the imbalance of the distribution network has become more prominent.
Determinants and Effectiveness of Extending the Duration of Adjuvant Hormone Therapy beyond 5 Years in Patients with Breast Cancer
Authors: Zeng Erwei , He Wei , Sjölander Arvid , Bergqvist Jenny , Czene Kamila
Published: August 2022

Clinical guidelines have recommended patients with high-risk breast cancer to extend adjuvant hormone therapy beyond 5 years. However, the prevalence, predictors, and outcomes of extended adjuvant hormone therapy in the real world remain unknown. By linking six Swedish health registries, we prospectively followed 13,168 patients with breast cancer (2005–2020) from their first prescription of tamoxifen or aromatase inhibitors and categorized them as extending or not extending adjuvant hormone therapy. Cox regression analysis was used to investigate whether extended therapy was associated with breast cancer outcomes. Among patients with breast cancer who were recommended to extend adjuvant hormone therapy by the national guidelines, the proportion of women who extended therapy increased 5 folds during the past 10 years, reaching 80.9% during 2018 to 2020. Patients were more likely to extend therapy after completing 5-year adjuvant hormone therapy if they were young [40 vs. ≥65 years: OR, 1.71; 95% confidence interval (CI), 1.13–2.58], had positive lymph nodes (OR, 2.25; 95% CI, 1.85–2.73), had high tumor grade (grade 3 vs. 1: OR, 1.79; 95% CI, 1.34–2.39), received chemotherapy (OR, 5.22; 95% CI, 4.19–6.50), had first-degree relatives who died from breast cancer (OR, 1.84; 95% CI, 1.21–2.81), or had a high income (OR, 1.23; 95% CI, 1.01–1.49). Extended use of adjuvant hormone therapy was statistically significantly associated with improved disease-free survival (HR, 0.72; 95 CI%, 0.55–0.95). This study provides real-world evidence showing the use and improved breast cancer outcomes of extended adjuvant hormone therapy beyond 5 years.

Significance:

The proportion of patients with breast cancer extending adjuvant hormone therapy beyond 5 years has increased dramatically in recent years, which is associated with improved patient outcomes.
Protocol of a Multicenter Cohort Observational Study of Cerebral Venous Thrombosis in China Mainland
Authors: Li Min , Gao Xiaogang , Yang Qi , Zhang Xuxiang , Chen Jian , Meng Ran , Ji Xunming
Published: August 2022

Epidemiological data on cerebral venous thrombosis in China are still lacking at present on the aspects of incidence, recurrence, risk factors, and so on. Herein, we aimed to fill the gap, based on the result of this multicenter prospective cohort study. A total of 26 top tertiary hospitals distributed in China Mainland will take part in this study. For the first time, a dataset of cerebral venous thrombosis cohort (including multiethnic patients of all ages in almost all regions of Mainland China, regardless of gender) will be built. Inclusion criteria were as follows: (1) aged ≥14 years, (2) neuroimaging-confirmed cerebral venous thrombosis, (3) symptom onset was within 30 days prior to enrollment, (4) signed the informed consent form. Demographic data, risk factors, clinical and neuroimaging features, ophthalmologic and aural results, blood tests, cerebrospinal fluid examination, therapeutic strategies, and adverse events were analyzed. Two milliliters of fasting venous blood and 2 mL of cerebrospinal fluid will be collected and stored. Furthermore, patients will be followed up at months 1, 3, 6, and 12 after baseline assessment. Primary outcome will be all-cause mortality. Secondary outcomes: (1) cerebrospinal fluid pressure and Frisen grade; (2) recanalization rate on imaging; (3) rating scales such as GCS, NIHSS, mRS, Mini-Mental State Examination, Montreal Cognitive Assessment, Patient Health Questionnaire 9-item, HIT-6, and Tinnitus Handicap Index. This study will for the first time provide strong evidence on the incidence rate, recurrence rate, and demographic data, as well as special risk factors, clinical outcomes, symptomatic and imaging features of cerebral venous thrombosis in Chinese population. The results of this study will also provide an important reference on prevention, early diagnosis, and customized treatment of cerebral venous thrombosis in Chinese patients.
Caderno de memórias coloniais e a discussão étnico racial em tempos de pandemia
Authors: Oliveira Gabriela de Castro Maciel de
Published: August 2022

A desigualdade social brasileira foi evidenciada pela pandemia, quando as camadas mais pobres, compostas, em sua maioria, por pessoas negras, ficaram sem acesso ao ensino escolar. Esse grupo é herança de um passado colonial escravocrata, e sofre os impactos do racismo estrutural. Por isso é necessário empenho numa educação antirracista que combata as estruturas que favorecem as desigualdades. Esta pesquisa apresenta o livro Caderno de memórias coloniais (2018) como uma obra que pode contribuir para a discussão das relações étnico-raciais, salientando os efeitos da colonização portuguesa que ainda hoje sustentam injustiças sociais em nossa sociedade.
Tipologia de expressões cristalizadas verbais do espanhol peninsular: um estudo preliminar e comparado
Authors: Fonseca Maria Caroline dos Santos , Rodrigues Roana
Published: August 2022

Este trabalho apresenta os resultados de um estudo piloto do comportamento sintático-semântico de expressões cristalizadas verbais (ECV) do espanhol peninsular (ESP), como “perderse la cabeza”, tendo como base a tipologia proposta por Vale (2002) para as ECV do português brasileiro (PB). Além disso, estabelece-se uma comparação preliminar entre expressões cristalizadas do ESP e seus equivalentes semelhantes do PB. Para o desenvolvimento da pesquisa, foram analisadas e classificadas 20 ECV do ESP em 5 classes distintas, segundo suas propriedades sintático-semânticas. Com isso, ao final da análise, pôde-se concluir que: (i) as expressões selecionadas apresentam um comportamento léxico-sintático-semântico semelhante nos dois idiomas; e (ii) determinados comportamentos de construções verbais livres se conservam nas expressões cristalizadas constituídas pelo mesmo verbo: em língua espanhola, por exemplo, verificou-se a seleção da preposição a na introdução de complementos humanos ou humanizados, e a maior incidência de expressões com verbos reflexivos.
Saisir la figure du lecteur à travers l’analyse du discours contrastive
Authors: Ronci Martina
Published: August 2022

L’analyse du discours contrastive (ADC) constitue un cadre théorique permettant de comparer des genres discursifs au sein de communautés discursives différentes. Dans cet article, nous adoptons ce cadre théorique afin d’examiner un ensemble d’ouvrages d’anglais et français langues étrangères (EFL et FLE) utilisés par des lycéens japonais entre 2017 et 2018. Les premiers (EFL) étant rédigés principalement par des auteurs d’origine japonaise, alors que les seconds (FLE) sont conçus par des équipes beaucoup plus mixtes, une approche comme celle de l’ADC permet de relever des choix qui peuvent dépendre des pratiques discursives des auteurs, ayant ici des origines différentes. Plus précisément, nous proposons une étude ciblée de la manière dont les auteurs des manuels s’adressent à leurs lecteurs/apprenants, explorant notamment l’utilisation de déictiques sur le plan énonciatif (KERBRAT-ORECCHIONI, [1999]2014) et de syntagmes nominaux relevant de fonctionnalisations au niveau sociolinguistique (VAN LEEUWEN, 2008). Les résultats de l’analyse contrastive permettent de constater deux pratiques différentes: d’une part, une inclusion qui s’effectue entre les auteurs (majoritairement japonais) des manuels d’anglais et leurs lecteurs, de l’autre une sorte d’exclusion opérée à travers le rappel fréquent du cadre scolaire qui est mis en place par les auteurs (français et japonais) des manuels de français.
Treme de alegria: o cravo enquanto ruído no processo de uma criação colaborativa
Authors: Farias Austeclinio Lopes de , Ribeiro Cardoso Pedro
Published: August 2022

O presente artigo tem como tema central o processo criativo na produção da peça Dedicado a um Jovem que Vagueia em uma Paisagem Vulcânica enquanto Treme de Alegria de autoria de XXXX, composta para e em colaboração com o cravista XXXX, e sua exploração das potencialidades do cravo enquanto instrumento voltado à geração de ruídos, e os elos que tal concepção proporciona em relação à escrita barroca. Na primeira parte do texto aborda-se os conceitos de liminaridade e espacialização, a fim de entender como o barroco musical, segundo o compositor e filósofo Hugues Dufourt, se salienta enquanto um código que tensiona noções puramente lineares da estruturação musical, culminando no erguimento do conceito de continuum. Em um segundo momento, abordaremos os entendimentos de figural como utilizado pelo filósofo Gilles Deleuze, e o de reescritura, como compreendido pelo compositor Silvio Ferraz, para inteirar procedimentos utilizados na montagem da composição aqui discutida. Após a introdução dos conceitos que operam na formalização da peça, se desenvolverá, por um ponto de vista técnico, como de qual forma as particularidades do cravo articulam tais noções, como também será relatado como se deu a colaboração no processo composicional.
A new species of the Arthuri Complex of the Strodei Subgroup of Nyssorhynchus (Diptera: Culicidae)
Authors: SANT’ANA DENISE CRISTINA , SALLUM MARIA ANICE MUREB
Published: August 2022

Nyssorhynchus (Nyssorhynchus) rondoniensis, a new species of the Arthuri Complex of the Strodei Subgroup, is described and validated using morphological characters of the adult male and female, male genitalia, fourth-instar larva and pupa. The new species is recorded in the municipalities of Campo Novo de Rondônia and Monte Negro, Rondônia State, Brazil. Based on DNA sequence data, the new species (as Ny. arthuri species C) was found to belong to a separate lineage within the Arthuri Complex. Morphological characteristics of the male genitalia and fourth-instar larva confirmed that the new species shared morphological similarities with other species of the Arthuri Complex, but it can be distinguished by characteristics of the male genitalia, adult female and larva. Nyssorhynchus rondoniensis may be involved in malaria transmission because females can be easily misidentified as Ny. oswaldoi (Peryassú, 1922) s.l. or Ny. konderi (Galvão & Damasceno, 1942) s.l. Both species were previously hypothesized to be local vectors in Acre and Rondônia States.
Transcriptional Factor Forkhead Box D1 Upregulates Sirtuin3 by Activating the Wnt/β-Catenin Pathway to Alleviate HTR-8/Svneo Trophoblast Cell Dysfunction in Preeclampsia
Authors: Zhao Zhiqiang , Zhang Chong , Zhu Yunxia
Published: August 2022

The proliferation, invasion, migration and apoptosis of trophoblast cells in preeclampsia are closely related to the occurrence and development of preeclampsia. Transcription factors forkhead box D1 and Sirtuin3 are abnormally expressed in preeclampsia, and Sirtuin3 plays a regulatory role in cell proliferation, invasion and apoptosis in related diseases. However, the studies on forkhead box D1 and Sirtuin3 in preeclampsia and their specific mechanisms have not been reported so far. In this study, the expression of Sirtuin3 in Human chorionic trophoblast cells HTR-8/Svneo was inhibited by cell transfection, and then the effects of Sirtuin3 expression in interfering cells on cell invasion, migration and apoptosis were detected by MTT, TUNEL, Western blot, wound healing and Transwell techniques. Subsequently, the binding between forkhead box D1 and Sirtuin3 was predicted by JASPAR website and verified by luciferase assay and ChIP assay. Finally, cell invasion, migration and apoptosis were detected after overexpression of forkhead box D1 and interference with Sirtuin3, and the Wnt/β-catenin signaling pathway was detected to explore the mechanism. We found that interfering with Sirtuin3 induced apoptosis of HTR-8/Svneo cells and inhibited cell invasion and migration. Forkhead box D1 transcriptional activation of Sirtuin3 alleviated HTR-8/SVneo cell dysfunction through activation of the Wnt/β-catenin signaling pathway. Overall, transcriptional factor forkhead box D1 can upregulate Sirtuin3 by activating the Wnt/β-catenin pathway to alleviate HTR-8/Svneo trophoblast cell dysfunction in preeclampsia.
Mindfulness in Surgical Care, Training, and Practice
Authors: Diller Maggie L.
Published: August 2022

There exists a robust amount of evidence supporting the broad application of mindfulness in a clinical environment. The evolution of mindfulness research is germane to modern surgical practice and education given its impact on patient outcomes, cognitive function, surgical skill, and mental health and wellbeing. “Mindfulness in surgical care, training, and practice” includes a series of articles that highlight the theoretical rationale behind mindfulness-based interventions (MBIs) for optimization of patient care and define its role in surgical education and practice. Furthermore, each article offers implementation strategies and best practices such that mindfulness-based interventions and curricula can be adapted to meet the unique needs of patients and providers existing within a diverse surgical environment. This series brings attention to the evolving archetype of surgical culture - one in which the wellbeing of individuals and communities is emphasized as fundamental to optimum patient care and outcomes.
Prospective Assessment of the Diagnostic Accuracy of Multi-site Photoplethysmography Pulse Measurements for Diagnosis of Peripheral Artery Disease in Primary Care
Authors: Stansby Gerard , Sims Andrew J. , Wilson Lesley , Beale Tom A W , Wightman James , Guri Ina , Wilkes Scott , Haining Shona , Allen John ,   NOTEPAD Study Team
Published: August 2022

Peripheral arterial disease (PAD) is associated with cerebral and coronary artery disease. Symptomatic PAD affects about 5% of people over 55 years; many more have asymptomatic PAD. Early detection enables modification of arterial disease risk factors. Diagnostically, assessment of symptoms or signs can be unreliable; ankle brachial pressure index (ABPI) testing is time-consuming and few healthcare professionals are properly trained. This study assessed the diagnostic accuracy of multi-site photoplethysmography (MPPG), an alternative non-invasive test for PAD, in primary care. PAD patients identified from general practice registers were age- and sex-matched with controls. Participants were assessed using MPPG, ABPI and duplex ultrasound (DUS). Outcome measures were sensitivity and specificity of MPPG and ABPI (relative to DUS) and concordance. MPPG test results were available in 249 of 298 eligible participants from 16 practices between May 2015 and November 2016. DUS detected PAD in 101/249 (40.6%). MPPG sensitivity was 79.8% (95% confidence interval [CI] 69.9–87.6%), with specificity 71.9% (95% CI 63.7–79.2%). ABPI sensitivity was 80.2% (95% CI 70.8–87.6%), with specificity 88.6% (95% CI 82–93.5%). With comparable sensitivity to ABPI, MPPG is quick, automated and simpler to do than ABPI; it offers the potential for rapid and accessible PAD assessments in primary care.
Book review: Sangit Kumar Ragi, RSS and Gandhi: The Idea of India
Authors: Rai Nitesh
Published: August 2022

Sangit Kumar Ragi, RSS and Gandhi: The Idea of India. New Delhi: SAGE Publications India, 2022. 335 pp., ₹1,395.
Blockchain Technology in Real-Time Governance: An Indian Scenario
Authors: Pandey Surabhi , Sen Chandra
Published: August 2022

Blockchain, the latest distributed ledger technology, has brought paradigmatic shift to the mode of transaction and communication recently. None of the arenas/sectors/organisations is untouched of the technology globally. Recently, the appliance of the distributed ledger technology into digital currency astonished the global community. The applications, apprehension, risks and prospective of technology, thus, have been analysed periodically. In this article, the authors try to understand the potential scope, complexity and legal dynamics of blockchain in the Indian scenario, intermittently. The basic sources such as reports and documents of NITI Aayog, Working Paper of Ministry of Information and Technology as well as reports of Finance Ministry are taken to start with. Moreover, guidelines and press-releases of the Reserve Bank of India, various judgements of the Indian Supreme Court and Ministers’ statements in the Indian Parliament and various initiatives of states have also been taken as references to critically comprehend the convolution of blockchain in the Indian context.
The Relationship Between Market Culture, Clan Culture, Benevolent Leadership, Work Engagement, and Job Performance: Leader’s Dark Triad as a Moderator
Authors: Lee Michelle C. C. , Ding Alyssa Y. L.
Published: August 2022

Benevolent leadership is one of the leadership styles which provides a positive influence on employees. However, the current leadership literature has yet to investigate how benevolent leadership leads to job performance, the processes involved, the relationship between organizational culture and benevolent leadership, and the role of dark side of leaders in affecting this relationship. Using the leader-culture fit framework within an Eastern context, the current study first investigates the relationship between benevolent leadership and job performance through work engagement. The study then compares two contrasting organizational culture (i.e., market culture and clan culture) on benevolent leadership. Finally, the study investigates how leaders’ dark triad affects the relationship between organizational culture and benevolent leadership. 374 full-time white-collar employees (Males = 54.01%; Mean age: 32.7 years) from various private organizations within the service industry participated in this study. The results showed that work engagement mediated benevolent leadership and job performance. Market culture showed a negative relationship with benevolent leadership while clan culture showed a positive relationship with benevolent leadership. Benevolent leadership mediated clan culture (but not market culture) and work engagement. Under a high market culture with a high dark triad leader, benevolent leadership is at its lowest level. Under a high clan culture with a low dark triad leader, benevolent leadership is at its highest level. The findings suggest the importance of benevolent leadership within a clan culture (rather than market culture), in aligning with the leader-culture fit framework in increasing employees’ work engagement and job performance.
When donor T cells attack: The curious case of liver transplant-associated acute graft-versus-host-disease
Authors: Deschner Max , Bastin Donald J. , Solh Ziad , Bosma Karen , Haddara Wael , Yang Ping , Broadbent Robert , Haig Aaron , Keow Jonathan , Brahmania Mayur , Xenocostas Anargyros , Deotare Uday
Published: August 2022

Graft versus host disease is a rare but deadly complication of solid organ transplant. Clinical features of graft-versus-host-disease are non-specific, which may lead to delayed diagnosis as more common conditions including infections or drug reactions are considered. We describe a 54-year-old male patient who underwent liver transplantation for alcohol use disorder-related cirrhosis and developed acute graft-versus-host disease. Initial clinical presentation included dermatitis, bone marrow failure and enteritis. Results of skin biopsy and cytogenetic studies were consistent with liver transplant-associated acute graft-versus-host disease. The importance of this case is to highlight to transplant physicians and surgeons the challenges of diagnosing graft-versus-host-disease. In our case, pre-existing partnerships among the liver and hematopoietic stem cell transplant teams, transfusion medicine specialists, critical care specialists and facilitated timely communication relevant to confirming graft-versus-host disease. We propose an algorithm to assist in the workup of suspected graft-versus-host disease. Because this condition is characterized by high mortality, a high index of suspicion is imperative for prompt diagnosis and optimal management of the donor-recipient immune interaction when patients present with classic clinical features.
Making Space: Exploring the “Thirdspace” of Breaktime in Middle School
Authors: Hice-Fromille Theresa , London Rebecca A.
Published: August 2022

Although scholars are attuned to the particular transitional dilemmas faced by middle school students, inquiry into middle school breaktimes is largely limited to research on bullying and peer victimization. This study interrogates the geography of middle school breaktime to expand understanding of student safety and recognize the ways that the state’s intervention in school spaces creates particular challenges for young learners. By investigating breaktimes at three middle schools and employing a critical geography lens in data coding and analysis, we demonstrate how the organization of space shapes student experiences. Findings suggest that scholars should consider breaktime as a “thirdspace” within the middle school day—one that offers vast potential for positive student development, but is marginalized due to its status as “non-academic” time. Findings reveal that school leaders and staff may better support students by addressing the ways that breaktimes are differently navigated by students along ethnic, socioeconomic, age, and gender lines.
The Exception that Became the Rule: A History of First-Generation Rent Control in Italy (1915-1978)
Authors: Iannello Aurora
Published: August 2022

This paper retraces the history of Italy’s first-generation rent control—a strict system of nominal rent freezes—from its adoption in 1915 to its final dismantling in 1978. It investigates the political and economic reasons why this policy was adopted, removed, intensified, or lightened at different times. In addition, this paper reports data on the evolution of rents in various Italian cities over the period considered, drawing them partly from published statistical sources and partly from archival research. In particular, it presents original data on controlled and uncontrolled rents in nineteen Italian cities between 1953 and 1975 (with gaps), taken from the Istat historical archive.
Long Term Use of Transcutaneous Electrical Nerve Stimulation at Newcastle Pain Relief Clinic
Authors: Johnson M I , Ashton C H , Thompson J W
Published: August 2022

This retrospective study of long-term use of transcutaneous electrical nerve stimulation (TENS) at Newcastle Pain Relief Clinic indicates that TENS has been a successful analgesic treatment for 58.6% of 1582 patients attending the climic over a period of 10 years. A wide range of pain conditions were found to respond to TENS and many patients continued to use the treatment for several years Most patients not responding to TENS (during a home trial) returned stimulators at the first follow-up appointment. Thus TENS should be considered as a siitple, safe and reusable first line treatment for many pain conditions.
Critical Ischaemia of the Upper Limb
Authors: Quraishy M S , Cawthorn S J , Giddings A E B
Published: August 2022

Fifty-seven patients who presented to the Royal Surrey County Hospital, Guildford, with critical upper limb ischaemia between 1980 and 1989 were studied. Only 13 patients had emboli, while 23 presented with arteritis, seven involving large vessels and 16 with small vessel disease. Other causes included nine patients with trauma, six with atherosclerosis (of whom five were women), and four with vascular complications of thoracic outlet obstruction. Single examples of ischaemia due to radiation fibrosis and disseminated intravascular coagulation were also seen. Critical ischaemia of the upper limb remains an uncommon yet challenging problem. The review demonstrates that total limb arteriography should be performed in all patients, except the minority who present with direct arterial trauma or classical emboli.
Why 100 Patients Failed to Keep an Outpatient Appointment — Audit in a Dermatology Department
Authors: Verbov J
Published: August 2022

Failure to keep outpatient appointments is common at all clinics and various explanations may be offered. One hundred attending patients who had failed to keep their previous dermatology clinic appointment were asked the reason for their non-attendance. Many and varied reasons were given but illness (28%), and problems related to appointments (33%) were prominent. They were also asked how. they had obtained a further appointment.

Stricter follow-up of non-attenders by the hospital including informingthe GP, and subsequent GP action if necessary, may improve attendance figures.
General Practitioners' Use of Non-Steroidal Anti-Inflammatory Drugs in Tayside and Fife Regions
Authors: Keys J , Beardon P H G , Jau C , Lang C C , McDevitt D G
Published: August 2022

The objectives of this study were to assess the prescribing of non-steroidal anti-inflammatory drugs (NSAIDs) by general practitioners and to determine their attitudes to problems caused by this class of drugs. The study consisted of two parts. The first was a questionnaire survey among general practitioners in Fife and Tayside, and the second was an analysis of NSAID prescribing over 12 months among the doctors in the Carnoustie Health Centre, using duplicate prescriptions.

In the questionnaire survey 61% of the general practitioners responded. The three most preferred drugs were buprofen (56%), naproxen (20%) and mefenamic acid (7%); choice of drug was determined by efficacy and personal experience. Gastrointestinal side effects were most frequently encountered, although there was little consensus amongst respondents as to their management. The duplicate prescription study showed that 14% of patients (1607 individuals) received at least one NSAID prescription in the year of study Ibuprofen (31%), naproxen (20%) and piroxicam (15%) were most frequently prescribed and up to 16% of the patients were co-prescribed a gastroprotective agent; ranitidine (75%) was the most commonly prescribed.

Despite the introduction of newere NSAIDs, ibuprofen and naproxen are still the most commonly prescribed drugs. Furthermore, although gastrointestinal side effects are commonly encountered, there is some uncertainty about their management.
Cerebellar Ataxia in the Elderly
Authors: Safe A F , Cooper S , Windsor A C M
Published: August 2022

In a retrospective study of 624 elderly patients referred with falls and gait disorders, 45 patients were found to have ataxia. Cerebrovascular diseases were the most common underlying cause of ataxia (15 patients, 37%). Nine patients had hereditary/degenerative cerebellar ataxia. History suggesting alcohol as an underlying cause was established in two patients with cerebellar ataxia. Three patients had normal pressure hydrocephalus and their condition improved remarkably after surgery. No definite cause was found in five patients. Cranial computed tomography (CT) showed cerebral atrophy in 16 patients and in three patients there was evidence of atrophy of the cerebellar vermis. Four patients had femoral neck fractures and three patients had other fractures. In a 5-year follow-up five patients died with bronchopneumonia (11% mortality) and patients with dementia showed rapid deterioration. All patients were referred to the day hospital for rehabilitation. The best treatment outcome was achieved in patients who had a single cerebrovascular accident with no cognitive impairment and in those whose ataxia was secondary to medication. Fourteen patients (44%) moved to residential care while 27 (66%) continued to live in their homes with community support.

We concluded that there is no evidence of increased mortality in the elderly patients with cerebellar ataxia. CT scan is mainly helpful in diagnosing specific diseases such as tumours or hydrocephalus. A significant proportion of elderly patients with ataxia may have reversible or treatable conditions and can pursue an independent life.
Cardiopulmonary Resuscitation Training Revisited
Authors: Goodwin A P L
Published: August 2022

The cardiopulmonary resuscitation (CPR) skills of 50 junior hospital doctors (22 house officers and 28 senior house officers) were assessed. Theoretical knowledge was measured by a multiple choice questionnaire and practical ability with the Laerdal Skillmeter Resusci Anne. Only 40% of the study group passed both tests. Those doctors who had previously received regular CPR training performed better in the practical test (P<0.05) than those who had not. Theoretical knowledge was unrelated to previous CPR training. It is recommended that junior hospital doctors should undergo regular CPR training every 6 months, in order to maintain their practical CPR skills.