bluuebunny/crossref_metadata_2025 huggingface dataset:
MERCOSUL E UNIÃO EUROPEIA: UMA ANÁLISE DA INTEGRAÇÃO COMERCIAL ENTRE OS BLOCOS ECONÔMICOS DE 2000 A 2018
Authors: Rosa Leonardo Gerhardt da , Franke Luciane , Sindelar Fernanda Cristina Wiebusch
Published: April 2023

O Mercosul e a União Europeia são importantes parceiros comerciais, no entanto, o uso de políticas protecionistas, por vezes, restringe suas relações. Buscando ampliar e facilitar essas transações, em meados de 2019, estes blocos decidiram por encaminhar sua união comercial. Apesar disso, ainda restam dúvidas sobre a queda das barreiras não tarifárias e os potenciais ganhos. Nesse sentido, este trabalho buscou identificar as principais características da integração comercial entre os blocos, analisando seu fluxo comercial de 2000 a 2018, a partir do índice de comércio intraindústria. Para a realização do trabalho utilizou-se dados secundários sobre importação, exportação e produtos comercializados, além da análise de barreiras aplicadas. Os resultados evidenciam que, apesar do aumento do fluxo comercial dos blocos no período, não houve crescimento no número de setores com integração intraindustrial, devido a diferença na pauta exportadora de ambos. Além disso, observa-se que as tarifas não são o maior empecilho para a ampliação das trocas, mas sim, o elevado número de normas regulamentares de acesso aos mercados, tanto no Mercosul como União Europeia.
Acquisition of the property right: An overview of prescription method analysis.
Authors: Gojani Skender , Hoti Lirie
Published: April 2023

Ownership acquisition has been one of the biggest problems to deal with within Kosovan society since the early times, especially in the post-war period. Not to mention that people were killed by each other on this topic. Laws and canons in years have tried to bring solutions to these cases. Some of the manias considered in these canons and laws were possible through exchanges, usurpation, and inheritances by which the ownership (Merriam-Webster, n.d.) was gained in generations. Therefore, knowing all of this, this paper aims to bring information on how the property was and continues to be acquired in Kosovo and the problems people have to deal with during this process. To reach our aims we used these methods: research method, historical and descriptive methods. The main findings of this paper identified and explained the challenges of ownership acquisition by good faith and clarified when one can be the owner of an immovable property. The relevance of this paper stands on the information given about this topic to the readers and also on the new research studies that will be done in the future.
Regulation of monocyte activation by PPARα through interaction with
the cGAS-STING pathway
Authors: Dong Lijie , Cheng Rui , Ma Xiang , Liang Wentao , Hong Yaru , Li Hui , Zhou Kelu , Du Yanhong , Takahashi Yusuke , Zhang Xiaomin , Li Xiaorong , Ma Jian-xing
Published: April 2023

  

Monocyte activation plays an important role in diabetic complications such as diabetic retinopathy (DR). However, the regulation of monocyte activation in diabetes remains elusive. Fenofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPARα), has shown robust therapeutic effects on DR in type 2 diabetic patients. Here we found that PPARα levels were significantly down-regulated in monocytes from diabetic patients and animal models, correlating with monocyte activation. Fenofibrate attenuated monocyte activation in diabetes, while PPARα knock-out alone induced monocyte activation. Furthermore, monocyte-specific PPARα overexpression ameliorated, while monocyte-specific PPARα knock-out aggravated, monocyte activation in diabetes. PPARα knock-out impaired mitochondrial function, while increasing glycolysis in monocytes. PPARα knock-out increased cytosolic mitochondrial DNA release and activation of the cGAS-STING pathway in monocytes under diabetic conditions. STING knock-out or STING inhibitor attenuated monocyte activation induced by diabetes or by PPARα knock-out. These observations suggest that PPARα negatively regulates monocyte activation through metabolic reprogramming and interaction with the cGAS-STING pathway.
Die große Furcht
Authors: Auge Oliver , Kollex Knut-Hinrik
Published: April 2023

Ganz Europa sei vom »Geist der Revolution« erfüllt, fürchtete der britische Premierminister David Lloyd George im März 1919 angesichts des Übergreifens politischer Umsturzbewegungen auf große Teile des Kontinents. Der gewaltigen Unzufriedenheit und dem Wunsch nach politischer Veränderung stand allerdings rasch die Angst vor deren unabsehbaren Folgen gegenüber. Russland war nach den Revolutionen des Jahres 1917 in einen brutalen Bürgerkrieg abgeglitten, Deutschland im Jahr darauf von der Novemberrevolution erfasst worden. Die teils von erheblicher Gewalt gekennzeichneten antirevolutionären Maßnahmen betrafen allerdings nicht nur die unmittelbare Nachkriegszeit. Nahezu das gesamte 20. Jahrhundert war vom Phänomen der Revolutionsangst beeinflusst. Expertinnen und Experten verschiedener historischer Fachbereiche analysieren anhand von Beispielen aus den vergangenen 100 Jahren die Furcht vor revolutionären Umbrüchen, deren Bedeutung und Auswirkungen.
Technologies Applied to Diagnosis and Treatment of Bruxism and Sleep Bruxism: Literature Review
Authors: Peixoto Lemos Freitas Luciana Cristina , Galvão Cecilia Santos , Chagas Freitas Júnior Amilcar , Almeida De Melo Laércio , Guedes de Souza Tasiana , Oliveira de Almeida Erika
Published: April 2023

Bruxism is considered an involuntary parafunctional habit. Sleep bruxism (SB) is characterized as an activity of the chewing muscles during sleep in healthy individuals, while bruxism in wakefulness (BV) is defined as an activity of the chewing muscles generating repetitive or sustained tooth contact and/or static and/or dynamic muscle contraction. This article is intended to carry out a literature review comparing current devices that help in the diagnosis and treatment of BS and BV, emphasizing scientific evidence. A literature review was carried out in the period from 2018 to 2020. In order to optimize diagnosis and treatment, new technologies have been proposed, acting directly to assess muscle contraction. Among them, the Brux off and Bite Strip have been used for the diagnosis of sleep bruxism, for the treatment of sleep bruxism the Grindcare, and for the treatment of bruxism during wakefulness, the Neuro up and the Unstrike your teeth. The technologies presented show promising results due to their practicality and ease, helping patients to diagnose and treat bruxism. However, more studies need to be carried out, presenting larger samples and with longer periods that will prove the real effectiveness of these new technologies.
A Methodology for Selection Starting Line-Up of Football Players in Qatar World Cup 2022
Authors: Hatem Belhouchet , Ikram Khatrouch
Published: April 2023

The process of player selection in multi-player sports is a complex multi-criteria problem. In Football, the role of a coach is selecting players as the starting line-up that is formed subjectively without regard to various criteria. The decision of the coach can impact team performance. This paper proposes a new model for selection starting line-up integrating criteria in FIFA World Cup 2022.The aim is to use MOORA method in football player selection process. We test the efficiency of the model using France National football team and we demonstrate how the methodology can facilitate decision making by selecting players.
The influence of the judge's gender competence on ensuring the equal access to justice
Authors: Fuley T.
Published: April 2023

Access to justice which is the necessary elements of the Rule of Law as well as Rechtsstaat enables individuals to effectively protect themselves against infringements of their rights. Since the modern international standards which the national judicial system must meet include not only independence, impartiality, competence and efficiency, but also gender sensitivity, therefore the gender competence of judges is not just the demands of the times or a fashionable trend, but primarily a guarantee of the equal access to justice.

Based on the specifics of the functions performed by a judge the article reveals the types of the judge’s gender competence such as expert, method and social competence. Also the author identified five core gender competencies for judges, which are: 1) interacting and communicating with the parties/participants of the process in an appropriate manner (without gender bias); 2) applying procedural legislation to the specific needs of participants in the process, taking into account the circumstances of the case (including the principle of gender equality); 3) searching for and interpreting the rules of substantive law through the use of national and international case law and legal instruments relating to gender equality and prevention of sex- and gender-based discrimination; 4) taking action to effectively protect the rights and legitimate interests of the individual, considering gender aspect; 5) drafting a judgement (judicial opinion writing) in compliance with the principles of gender equality and non-discrimination. Accordingly, in each of the competencies, the necessary knowledge, skills and qualities (values, attitude) of a judge have been identified, corresponding to the three components of the structure of gender competence – cognitive, activities-related and encompassing values and attitudes.

On the basis of analysis of the ECtHR case law some examples of violations by national courts of the requirements of the rule of law regarding access to justice are shown, and it is concluded that quite a few violations of the Convention on the Protection of Human Rights and Fundamental Freedoms could be avoided in a wide range of cases if judges possessed a sufficient level of gender competence, in particular, if they were able to recognize gender-sensitive situations when considering different categories of cases and react appropriately to them. Therefore, the acquisition of gender competences by judges, in particular through training, will contribute to ensuring the equal access to justice, which is one of the strategic objectives of the Council of Europe.
To the issue of the labor legal status of an employee of a state executive service body
Authors: Manzhak B.
Published: April 2023

The task of this article is to study the labor legal status of employees of the state executive service, in particular civil servants. Since the study of the legal status allows to determine all the subjective legal rights, freedoms and obligations belonging to the citizen, which determine his legal position in society, enshrined in the current legislation, as well as the system of guarantees for ensuring such rights and freedoms. It is noted that when characterizing the legal status of a civil servant of a state executive service body, it is necessary to pay attention to the organizational and legal aspect of power. In this sense, it is defined as a way to impose one's will on other subjects and direct their behavior and actions in the direction determined in accordance with legal norms. Summarizing what was stated in the article, it was concluded that the state executor is an official who is endowed with state-authority powers and is authorized to represent the interests of the state in the sphere of execution of decisions of courts and other bodies (officials). The legislator grants employees of the state executive service a special legal status, which determines the peculiarities of their legal position among other persons, and is endowed with a special legal personality, specific additional rights and obligations, and responsibility. It was concluded that a civil servant of a state executive service body as a subject of labor law is the bearer of labor law status, i.e. a set of rights, obligations, guarantees, restrictions, as well as other legally significant properties that characterize the level of possible and necessary behavior of a civil servant as an employee, reflect the benefits and privileges due to him, necessary to ensure the normal performance by him of his job functions and duties due to his position.
Phoretic mite assemblage of the pinyon pine beetle, Ips confusus (Curculionidae: Scolytinae), in Arizona
Authors: Hofstetter Evan M. , Knee Wayne H. , Khaustov Alexander A.
Published: April 2023

Mites are among the most common associates of bark beetles and they can influence the ecology and microbial composition within bark beetle-colonized trees. The pinyon pine engraver, Ips confusus is a common beetle in pinyon trees in the southwestern United States, but the mite composition associated with this beetle has been little studied. In this study, we quantify the abundance, diversity, and attachment locations of phoretic mites on Ips confusus that emerge from naturally infested trees. In total, we observed 342 beetles for mites, 95% of which had at least one mite. We collected a total of 5842 mites, representing seven families and seven species: Cercoleipus coelonotus (Cercomegistidae) Dendrolaelaps quadrisetosimilis (Digamasellidae), Ereynetes propescutulis (Ereynetidae), Iponemus confusus confusus (Tarsonemidae), Mexecheles cf. virginiensis (Cheyletidae), Proctolaelaps subcorticalis (Melicharidae), and Trichouropoda californica (Trematuridae). We calculated the average number of mites per beetle to be 18, with a maximum of 147 mites on a single beetle. The vast majority of mites (98% of total abundance) was represented by three species (I. c. confusus, D. quadrisetosimilis, and T. californica). Attachment locations on the beetle varied across mite species, with mite species exhibiting a preference for specific locations. Mite abundances on emerging host beetles varied over time, with some species occurring mostly on early-emerging beetles, while others occurred on later emerging beetles.
Erosive and ulcerative stomatitis in dogs and cats: which immune-mediated diseases to consider?
Authors: Bizikova Petra , Linder Keith E. , Anderson Jamie G.
Published: April 2023

Immune-mediated and autoimmune diseases of the skin often present with oral cavity involvement. Autoimmune subepidermal blistering diseases and pemphigus vulgaris are classic examples. While the primary lesions (vesicles and bullae) are relatively specific, these fragile lesions evolve rapidly into erosions and ulcers, which are lesion types that overlap with many diseases. Furthermore, some immune-mediated diseases such as severe adverse drug reactions, lupus diseases, canine uveodermatological syndrome, and vasculitis, may or may not involve the oral cavity, and often nonoral clinical manifestations are more diagnostic. In these situations, disease knowledge combined with signalment, lesion distribution, and history help to narrow the differentials. Surgical biopsy is required for confirmation in most diseases, while immunosuppressive treatments most typically involve glucocorticoids with or without nonsteroidal immunosuppressants.
Low-dose epidural anesthesia decreases the use of intraoperative systemic analgesics in goats undergoing lower urinary tract surgery
Authors: Martin-Flores Manuel , Nugen Sarah A. , Boesch Jordyn M. , McOnie Rebecca C. , Araos Joaquin , Campoy Luis , Gleed Robin D.
Published: April 2023

OBJECTIVE

To test whether the use of low-dose epidural anesthesia (EA) in goats undergoing lower urinary tract surgery reduces the requirements of perioperative analgesics, contributes to intraoperative hypotension, and improves postoperative comfort during the first 24 hours after surgery.

ANIMALS

Retrospective analysis of 38 goats between January 2019 and July 2022.

PROCEDURES

Goats were divided into 2 groups (EA or no EA). Demographic characteristics, surgical procedure, time of anesthesia, and anesthetic agents used were compared between treatment groups. Outcome variables potentially related to the use of EA included dose of inhalational anesthetics, incidence of hypotension (mean arterial pressure < 60 mm Hg), intraoperative and postoperative administration of morphine, and time to first meal after surgery.

RESULTS

EA (n = 21) consisted of bupivacaine or ropivacaine 0.1% to 0.2% with an opioid. There were no differences between groups except for age (EA group was younger). Less inhalational anesthetic (P = .03) and less intraoperative morphine (P = .008) were used in the EA group. The incidence of hypotension was 52% for EA and 58% for no EA (P = .691). Administration of postoperative morphine was not different between groups (EA, 67%, and no EA, 53%; P = .686). Time to first meal was 7.5 hours (3 to 18 hours) for EA and 11 hours (2 to 24 hours) for no EA (P = .057).

CLINICAL RELEVANCE

Low-dose EA reduced the use of intraoperative anesthetics/analgesics in goats undergoing lower urinary tract surgery without an increased incidence of hypotension. Postoperative morphine administration was not reduced.
The effect of adding a heated humidified breathing circuit on body temperature in healthy anesthetized dogs
Authors: Jones Susan M. , Burns Charlotte C. , Reed Rachel A. , Quandt Jane E. , Barletta Michele , Sakai Daniel M.
Published: April 2023

OBJECTIVE

To compare the effect of a circulating warm water blanket (WWB) in combination with a heated humidified breathing circuit (HHBC) heated to 45 °C on rectal temperature (RT) in dogs undergoing general anesthesia for elective ovariohysterectomies.

ANIMALS

29 healthy dogs.

PROCEDURES

Dogs in the experimental group (n = 8) and dogs in the control group (21) were connected to an HHBC and a conventional rebreathing circuit, respectively. All dogs were placed on a WWB in the operating room (OR). The RT was recorded at baseline, premedication, induction, transfer to OR, every 15 minutes during maintenance of anesthesia, and extubation. Incidence of hypothermia (RT < 37 °C) at extubation was recorded. Data were analyzed using unpaired t tests, the Fisher exact test, and mixed-effect ANOVA. Statistical significance was defined as P < .05.

RESULTS

There was no difference in RT during baseline, premedication, induction, and transfer to OR. The overall RT was higher for the HHBC group during anesthesia (P = .005) and at extubation (37.7 ± 0.6 °C) compared with the control group (36.6 ± 1.0 °C; P = .006). The incidence of hypothermia at extubation was 12.5% for the HHBC group and 66.7% for the control group (P = .014).

CLINICAL RELEVANCE

The combination of HHBC and WWB can reduce the incidence of postanesthetic hypothermia in dogs. Use of an HHBC should be considered in veterinary patients.
Small and medium enterprises shooting for the stars: what matters, besides size, in outer space economy?
Authors: Jora Octavian-Dragomir , Roşca Vlad I. , Iacob Mihaela , Murea Maria-Mirona , Nedef Matei-Ștefan
Published: April 2023

The popular mindset and widespread narrative, at least until not so long ago, was that in outer space affairs the fiefdom belongs, politically and economically, to governments and big businesses. An array of alliances between few states and their privileged partners from the corporate world constituted the highly exclusivist space ecosystem. Little room was supposed to be available to non-full-fledged spacefaring nations and enterprises originated from them, a configuration furthermore jammed by the fact that international agreements – i.e., the “Outer Space Treaty” (1967) an the “Moon Treaty” (1979) – seem to be rather dismissive of extensive exploitation of celestial bodies, adding to the already prohibitive costs of such endeavours if legitimized. Devoted mainly to scientific exploration paired with exploitation only of planetary proximities – viz., the large satellite population orbiting the Earth, with their support and serviced industries, all estimated at half a trillion dollars –, the space economy, in its high-tech dimension, steadily democratized itself, becoming more competitive, and collaborative too, opening up to small and medium enterprises (SMEs), many coming from emerging spacefaring nations. The literature covering SMEs contribution to the development of the space economy is on track of consolidation, as the process itself is unfolding, with data covering only the most powerful space players (e.g., US, EU). Valuable insights are added starting from the common wisdom that institutions (channelling economic information and incentives) are the main drivers in space development, rather than business size, even more in a competitive- collaborative global economy. A case study is dedicated to the Romanian experience (that of a relatively new and little player in European/global space affairs). A conclusion is that in an economy of unbounded creativity and borderless capital, visionary enterprises, big or small, fit even into the space industry value chains, if a pro-market, pro-business climate is secured.
Phosphor conversion for WLEDs: YBO3: Ce3+, Tb3+ and its effects on the luminous intensity and chromatic properties of dual-layer WLED model
Authors: My Le Thi Thuy , Thai Nguyen Le , Bui Thuc Minh , Lee Hsiao-Yi , Anh Nguyen Doan Quoc
Published: April 2023

Yttrium borate phosphor co-doping Ce3+, Tb3+ ions (YBO3: Ce3+, Tb3+) is fabricated using solid state reaction, and then its luminescence is investigated through the computational energy transfer process. Under excited near-UV light, this YBO3: Ce3+, Tb3+ phosphor exhibits strong absorption with broad and sharp emission bands due to the 4f – 5d and 5d – 4f transitions of Ce3+ ions and the 4f – 4f transition of Tb3+ ions, respectively. The phosphor's emission chromaticity could be tunable by adjusting the concentration of doping ions. With 15% Tb3+ and 3% Ce3+ in the composition, the phosphor can gain maximum 76.7% external quantum efficacy. The phosphor is proposed for utilization in the phosphor package of white light-emitting diodes (WLEDs) to enhance their lighting performances. The findings point out that by modifying YBO3: Ce3+, Tb3+ concentration (5% – 10%), improvements in luminous intensities, color consistency, and color rendering indices can be observed. The higher concentration (10%) of YBO3: Ce3+, Tb3+ is more advantageous to the luminous flux and chromatic uniformity in cases of 4000 K and 5000 K WLEDs, while lower (5%) concentration greatly benefits those properties in the case of 3000 K WLED. Regardless of CCTs, the WLEDs show a reduction in chromatic reproduction efficiency with the increasing concentration of YBO3: Ce3+, Tb3+. Hence, this green phosphor could be a good material for high-luminescence WLED, yet the modification of phosphor concentration is advisable if the simultaneous good chromaticity is desired.
A case report of cardiac tamponade as a result of pericardial damage from chest compression
Authors: Alhamdan Qais , Alshahrani Hezam , Alamri Ayman , Alsaadi Saud , Khushayl Abdullah , Alzahrani Fahad
Published: April 2023

Background: It is well-recognized that manual chest compression could cause a number of internal injuries, many of which are fatal. Similar to this, many type A acute aortic dissection (AAD) patients who develop cardiac tamponade die before reaching the hospital. This study presented a case in which pericardial laceration brought on by chest compressions has unintentionally caused cardiac tamponade by AAD.
Case Presentation: A 65-year-old woman with a history of systemic hypertension was presented who fainted shortly after complaining of terrible epigastric discomfort. Paramedics started manual chest compressions on the patient, as soon as they realized they were dealing with a cardiopulmonary arrest. The pericardial laceration brought on by chest compressions might have unintentionally freed cardiac tamponade caused by AAD, perhaps sparing the patient's life. During surgery, a hemothorax and pericardial laceration connected to the left pleural space were found, but no heart injury was seen. There were no indications of the ruptured aortic aneurysm or any intra-thoracic injuries that would have caused the hemothorax. Hemiarch replacement was successfully accomplished, but the patient died from multi-organ failure 31 days after the operation.
Conclusion: An instance of non-fractured pericardial injury caused by chest compression was presented. The pericardial laceration, which also afforded the patient enough time for surgery, have accidentally eased the hemothorax brought on by the AAD.
An Assessment of Community Pharmacists’ Competence and Involvement in Adolescent Sexuality Education and Reproductive Health Services
Authors: Adje David , Chinenye Umeokwoaka Vivian
Published: April 2023

Background: Provision of sexuality education and reproductive health (SERH) services for the adolescent population has been inadequate. Increasing access to adolescent SERH through the community pharmacy is a viable option in bridging this gap.
Objective: The study objectives were to assess community pharmacists’ involvement, self –reported competence, confidence and comfort level regarding provision of adolescent SERH services and explore barriers to service delivery.
Method: A pre-tested questionnaire was distributed to 200 community pharmacists by simple random sampling. Self-reported competency and confidence were measured on a Likert scale ranging from 1-5, midpoint 3. Continuous data was expressed as mean and standard deviation while categorical data was expressed as frequencies and percentages.
Results: Community pharmacist’ self- reported competence, confidence and comfort levels were high, 4.09 ± 0.14; 3.2±0.75; 4.17± 0.18 respectively on a Scale of 1-5. Majority of the pharmacists, 130 (81.3%) claimed to have had formal training in sexuality education and nearly three quarters, 105 (65.6%) had recently updated their knowledge. Although product availability was adequate, 118 (73.6%), availability of educational materials was low, 37 (23%). Schools were the most frequent place where pharmacists had distributed sexuality education materials 96 (60%). Lack of time and religious objection were the major barriers to service delivery 99(61.9%); 63(39.4%) respectively.
Conclusion: Pharmacist’ self-reported comfort, competency and confidence levels in delivering adolescent SERH services were high. The major barriers to service delivery were lack of time and religious objection. These findings suggest that community pharmacists have a potentially major impact on improving access to adolescent SERH service. Therefore, the option of delivering SERH services through pharmacies is worth exploring in order to improve access and service delivery to the adolescent population.
FAKTOR-FAKTOR YANG MEMPENGARUHI KETEPATAN WAKTU PELAPORAN KEUANGAN
Authors: Purnama Sari Mutia , Y. Agus Bagus Budi N
Published: April 2023

Penelitian ini bertujuan untuk menguji pengaruh Opini Auditor, Profitabilitas, Hutang, Ukuran Perusahaan terhadap Ketepatan Waktu terhadap Pelaporan Keuangan. Populasi yang digunakan dalam penelitian ini adalah 32 Perusahaan sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia periode 2016-2021. Penelitian ini dilakukan dengan menggunakan metode kuantitatif. Data yang digunakan dalam penelitian ini adalah data Sekunder, yaitu data berasal dari laporan keuangan yang diungkapkan dalam mata uang Rupiah. Mtode purposive sampling yag dilakukan dalam penelitian ini memperoleh 12 sampel Perusahaan. Teknik analisis dalam penelitian ini adalah analisis regresi logistic menggunakan SPSS versi 23. Hasil dari pengujian hipotesis dalam penelitian ini bahwa Profitabilitas dan Ukuran Perusahaan terhadap ketepatan waktu dalam pelaporan keuangan menunjukkan berpengaruh signifikan positif, sedangkan Opini Auditor, dan Hutang tidak berpengaruh signifikan terhadap ketepatan waktu pelaporan.
PENGARUH BRAND EXPERIENCE TERHADAP BRAND LOYALTY DENGAN CUSTOMER ENGAGEMENT SEBAGAI VARIABEL MEDIATOR PADA PRODUK FASHION DI INDONESIA
Authors: Iman Aljenadryn Adzani , Kurniawati
Published: April 2023

Tujuan dalam penelitian yaitu untuk menganalisis pengaruh dimensi brand experience, customer engagement yang mempengaruhi brand loyalty konsumen produk fashion di Indonesia. Dengan melakukan penyebaran kuesioner kepada 132 responden, pegambilan sampel pada penelitian ini menggunakan non-probabilitas sampling dan purposive sampling. Metode analisis data menggunakan structural equation modeling (SEM) dan software AMOS22. Hasil menampilkan variabel sensory brand experience berpengaruh positif terhadap brand engagement. Kemudian affective brand experience, behavioral brand experience, intellectual brand experience mempengaruhi positif juga signifikan terhadap customer engagement dan customer engagement mempengaruhi positif juga signifikan terhadap customer loyalty. Adapun saran bagi perusahaan fashion di Indonesia adalah meningkatkan sensory brand experience, affective brand experience, behavioral brand experience, intellectual brand experience untuk konsumen agar konsumen dapat terlibat dan loyal terhadap merek.
PENGARUH RASIO KECUKUPAN MODAL TERHADAP PROFITABILITAS PERBANKAN KONVENSIONAL YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Nuroktaviani Dea , Susy Muchtar
Published: April 2023

Penelitian ini bertujuan untuk menguji pengaruh Capital Adequacy Ratio (CAR), Assets Size, Assets Quality, dan  Liquidity terhadap Profitabilitas. Metode penelitian ini menggunakan teknik purposive sampling. Populasi dalam penelitian ini adalah perusahaan perbankan konvensional yang terdaftar pada Bursa Efek Indonesia (BEI) dengan total sampel sejumlah 38 perusahaan perbankan konvensional dari 47 perusahaan yang terdaftar dalam kurun waktu 5 tahun periode 2017-2021. Data diperoleh dari website Bursa Efek Indonesia berupa Laporan Keuangan dan Laporan Tahunan. Penelitian ini menggunakan Teknik analisis berganda dengan software E-Views 12.0. berdasarkan pada data yang dikumpulkan pengujian ini dilakukan pada 190 sampel perusahaan dengan model regresi berganda dapat disimpulkan bahwa Aseet Size berpengaruh negatif signifikan terhadap Profitabilitas, serta Liquidity berpengaruh positif signifikan terhadap Profitabilitas. Sedangkan Capital Adequacy Ratio dan Asset Quality tidak berpengaruh terhadap Profitabilitas.
Legal recognition of artificial intelligence technologies in the context of the constitutional values of the Russian state
Authors: Volkov Vladislav Eduardovich
Published: April 2023

The purpose of the article is to form approaches to the public legal regulation of artificial intelligence technologies. The subject of the work is the social relations that have developed in the field of legal registration of modern digital technologies of "weak" artificial intelligence - computer vision, natural language processing, speech recognition and synthesis, as well as intellectual decision support. The relevance of the research is determined by the need to bring the content of legal acts in line with the current level of information technology development. The work is based on a combination of general philosophical, general scientific and special methods of cognition – concrete historical analysis, formal legal (dogmatic) method, as well as the method of comparative jurisprudence. The author criticizes the anthropomorphic approach to understanding artificial intelligence, based on the analogy of technology with the human mind, implemented in the terminological apparatus of existing legal acts. It is proposed to limit the legal interpretation of artificial intelligence to a set of specific information technologies that can be used by a person in solving applied problems. The analysis of possible directions of constitutional and legal recognition of artificial intelligence technologies and the legal consequences of their influence on the implementation of the constitutional values of equality and privacy is carried out. The argumentation in favor of a combination of social and technical regulation of relations in the field of application of artificial intelligence technologies is proposed.
SOURCES OF FINANCING ACTIVITIES IN THE REPORTING OF ECONOMIC ENTITIES OF VARIOUS GROUPS
Authors:   Orenburg State University, Orenburg, Russia, Sviridova L. A. , Terentyeva T. A. ,   Orenburg State University, Orenburg, Russia
Published: April 2023

Abstract. The paper studies the issues of compiling accounting forms for groups of economic entities (commercial organizations of the real sector, non-profit organizations of the real and public sector, organizations of the public sector), taking into account the peculiarities of disclosing information about the sources of financing of their activities for the purpose of external and internal control of the reliability of information. An assessment is made of the content of the current state of the regulatory framework for the preparation of financial statements by various groups of economic entities in terms of reflecting sources of financing in it, in order to control the reliability of information. The methodological basis of the work was the general scientific principles and methods of research: analysis and synthesis, logical linking, systematization. The author’s systematization of regulatory regulation in relation to the requirements for information on sources of financing disclosed in the balance sheet is presented, taking into account the characteristics of subjects of the commercial, public and public sectors of the economy, and a classification of their reporting forms is carried out. The shortcomings of the normative regulation of reporting were identified and proposals were developed for their elimination. The grouping of forms of financial statements depending on the groups of economic entities that have essentially different sources of financing activities is given. A critical assessment of the procedure for compiling the balance sheet and reflecting in it information about the sources of financing for the activities of non-profit organizations and public sector organizations is given. It is necessary to change the conceptual approaches to the disclosure of information about the source of funding for the activities of public sector organizations in order to strengthen external financial control. The proposed author’s approach to identifying sources of financing for the activities of various groups of economic entities, and reflecting information about this object in their balance sheet, can be implemented both in the process of improving legal regulation and in the process of reporting by economic entities, especially for public sector organizations. The main results obtained by the authors allow a professional accountant to adequately implement the requirements of federal standards regarding the reflection of information about sources of financing in the reports of economic entities of various groups and control the reliability of this information.
Peter the Great: The Image of the Russian Tsar in East Asia
Authors: Philippov A. V.
Published: April 2023

The peer-reviewed collective monograph “The Image of Peter the Great in the Countries of East Asia” was prepared by scholars from St. Petersburg State University and the Institute of Oriental Manuscripts of the Russian Academy of Sciences. This book examines the features of the perception of the image of the first Russian Emperor Peter the Great (1672–1725) in China, Japan, South Korea and Vietnam. The main content of ideas about this Russian Tsar in these countries is revealed, the sources and ways of disseminating these ideas are considered. The study covers the chronological framework from the reign of Peter the Great to the 21st century. Archival texts of the 18th century, works of the 18th – 19th centuries, articles by publicists of the 19th – 20th centuries, works of modern historians of the considered countries, publications of various genres on the Internet, translations of Russian works about Peter the Great, educational and children's literature, documentaries and other materials have been studied. The specificity of interpretation in different ethno-cultural environments of facts about the life and work of the Tsar is explained.
Encyclopedia of World Tea Culture and a Practical Reference Book
Authors: Xiaoling Zhang
Published: April 2023

A two-volume scholarly publication edited by Zhou Guofu, head of the China International Tea Culture Institute,  A Compendium of Global Tea culture (2019), is a practical guide that explains how tea and tea culture from China spread throughout the world, and how different countries used tea to expand trade and cultural exchanges. The book traces the general meaning, references historical events, and performs a deep analysis of tea culture. The book is notable for its reasoning, harmony, consistency of presentation and rich content. That is why the book is deservedly called “The Encyclopedia of World Tea Culture”.
Three Elite Burials of the Northern Zhou Period from Guyuan in Ningxia, China
Authors: Kudinova M. A. , Shulg D. P.
Published: April 2023

The materials of elite burial complexes of the Northern Zhou period (557–581) discovered in the 1980–1990s in the vicinity of Guyuan City in the Ningxia-Hui Autonomous Region of China are analyzed in this article. Due to the epitaphs engraved on stone slabs found inside the tombs, the names of the buried individuals and the exact dates of the complexes are known: the tombs belong to high-ranking officials of Northern Zhou: Yuwen Meng (565), Li Xian (569) and Tian Hong (574). The complexes under consideration demonstrate a high degree of unification of the funeral rite, which is manifested in the similarity of tomb structures, decor and accompanying grave goods. The features of architectural structures and grave goods of these burials continue the traditions of the previous periods of the Sixteen Barbarian States and the Northern Wei. With a general similarity to the synchronous complexes of the Northern Qi (550– 577), the materials of these tombs allow to distinguish specific features of the Northern Zhou funerary practice: the absence of porcelain items, the use of ritual nephrites, and the secular nature of mural paintings. Against the background of the prevailing influence of the Chinese-Han funerary tradition, there are signs of the influence of the steppe (probably Xianbei) funeral and memorial rituals. Prestigious items imported from Iran, Central Asia, Byzantium testify to the significant role of contacts along the Silk Road in the economical and cultural development of Northern Zhou. Despite the available data from written and epigraphic sources, the problem of identifying the ethnicity of the buried has not yet been resolved. However, the version of their non-Chinese origin seems to be the most probable.
Three Medieval Chinese Paintings about Girls Leaving for Foreign Lands and Their Historical Background
Authors: Varenov A. V.
Published: April 2023

The article deals with three Chinese paintings, created in the 13th century. All three scrolls depict different personages living at different times, however the general plot remains the same: an enforced departure of a girl to a foreign land.

Zhang Yu’s painting “Wenji returns to Han” tells of an Eastern Han poetess Cai Yan (Cai Wenji), who was a Xiongnu captive for 12 years, redeemed at the beginning of the 3rd century AD by a famous Chinese warlord, poet and politician Cao Cao. Gong Suran’s scroll “Ming-fei leaves the fort” illustrates a legendary story of Wang Zhaojun, one  of the “four great beauties of ancient China” and a concubine of the Western Han Emperor Yuan-di, who married  a Xiongnu chieftain in the last third of the 1st century BC to save her country from nomad invasion. The third painting looks the most realistic, however the reason for the creation of “Nomads” by Hu Huan is unknown. The author argues that all three paintings, in various artistic form, reflect the same historical event which happened in 1214. This was the enforced marriage of a Jin Empire princess Qi to the Mongolian chieftain Genghis Khan as a condition set by him to raise the siege of the Jin capital. Paintings by Zhang Yu and Gong Suran treat this event allegorically and Hu Huan’s “Nomads” – realistically.
Caracterização e análise epidemiológica dos casos de sífilis gestacional no município de Imperatriz, Maranhão, Brasil
Authors: Rebouças Eyshila Souza , Santos Raíssa Vieira , Rocha Martiniano de Araújo , Soares Stéphanie Cristina Ramos , Silva Hioara Kely Arcanjo da , Moreira Marcelo Hubner , Freitas Ermilton Júnio Pereira de
Published: April 2023

Objetivo: descrever o perfil epidemiológico dos casos de sífilis gestacional no município de Imperatriz–MA, no período de 2011 a 2021. Métodos: caracteriza-se como um estudo descritivo, quantitativo e retrospectivo, que realizou a análise dos casos de sífilis gestacional no município de Imperatriz-MA, utilizando-se de dados secundários obtidos do SINAN e analisados e descritos utilizando a ferramenta Microsoft Excel. Resultados: Entre os anos de 2011 e 2021 um total de 695 casos de sífilis gestacional (média anual 63,18; ± 61,81) foi contabilizado. O estudo obteve uma maior prevalência de casos nas gestantes que apresentavam ensino fundamental incompleto (n= 226 casos; 32,52%), faixa etária de 20 a 39 anos (n= 461 casos; 66,33%) e pele parda (n= 570; 82,01%). A maioria dos casos foi diagnosticado na forma latente da doença (n= 463 casos; 66,62%). Considerações finais: conclui-se que ao longo dos anos de 2011 a 2021 a cidade de Imperatriz-MA apresenta, sobretudo nos 4 anos mais recentes, um aumento expressivo na incidência de casos, reforçando a necessidade do aprimoramento das medidas de controle de IST’s, com destaque a sífilis na população de gestantes, em detrimento dos seus desfechos negativos para a saúde materno-fetal e consequências resultantes da sífilis congênita.
Comparison between Ethylcellulose and Polymethacrylate Topical Nanosponges Loaded with Butenafi ne Hydrochloride
Authors: Hussein Hayder H. A. , Kassab Hanan J
Published: April 2023

In this study, nanosponges (NS) loaded with butenafi ne hydrochloride (a broad-spectrum benzylamine antifungal agent) were successfully prepared by emulsion solvent diff usion method using ethylcellulose or polymethacrylate as retarder polymers. PVA was used as a stabilizer. NS 18 formulations were formulated with various ratios of 1:1, 1:2, and 1:3 (%, w/w), using diff erent PVA concentrations of 0.25, 0.5, and 0.75 (%, w/w). The prepared formulations were tested for particle size in terms of diameter, which ranged from (73.6 ± 15.4–991 ± 11.2 nm) for ethylcellulose NS, and from (116 ± 0.96–1439.6 ± 237.4 nm) for polymethacrylate NS. The entrapment effi ciency of the selected formulas (F1, F10) were (74.12 ± 2.60%) and (72.89 ± 1.41%). The selected formulas F1 and F10 were also evaluated for their polydispersity, yield, and in-vitro drug release. The release of BFNS powder in F10 (90.42 ± 1.81%) was higher than that of ECNS F1 powder (78.53 ± 3.24%) within 24 hours. Evaluation tests of the scanning electron microscope (SEM), Fourier transform infrared ray (FTIR), and powder X-ray diff raction (PXRD) confi rmed the NS’ spherical and porous features, the absence of any drug polymer interaction, and the stability of the drug in the delivery system. The two formulas of F1 and F10 were found to exhibit prolonged drug release, which minimizes side eff ects and dosing frequency of BF drug application.
Formulation and In-vitro Evaluation of Two Layers Tablet for Dual Release of a Model Drug
Authors: Mohammed Mushtaq J , Ali Wedad K
Published: April 2023

Objective: Glimepiride is a third-generation sulfonylurea medication that has been used to treat type 2 diabetes (T2D) mellitus. It is class II drug according to the biopharmaceutical classifi cation system (BCS) characterized with its low solubility and high permeability. Due to the drug’s weak water solubility, its bioavailability is restricted by its dissolving rate. This study aimed to develop a bilayer tablet of glimepiride with one layer for immediate release (IR), a dose of 2 mg, a second layer for sustained release (SR), and a 4 mg dose Immediate release layer included solid dispersion of glimepiride . Methods: Glimepiride solid dispersions were prepared utilizing four water-soluble carriers (poloxamer 188, polyethylene glycol (PEG6000), Kollicoat IR and soluplus) by solvent evaporation and fusion techniques at 1:1, 1:2, and 1:4 ratios and evaluated in 0.1 N of HCL buff er pH 1.2 with 1% of sodium lauryl sulphate (SLS) for 2 hours. utilizing a USP-II paddle-type dissolution apparatus containing 900 mL dissolution medium kept at 37 ± 0.5℃ and 50 rpm. The sustained release layer of glimepiride bilayer tablet was prepared using various polymers, including HPMC K15, HPMC K4, xanthan gum, carbopol 934 and ethyl cellulose at 1:1, 1:2,1:3 ratios and combination of polymers in phosphate buff er pH 6.8 for 12 hours. The prepared solid dispersion of immediate release were evaluated by X-ray powder diff raction (PXRD), and fourier transform infrared spectroscopy for selected SD9. The FTIR spectroscopy analysis for selected formula (F24) of sustained layer, angle of repose, Hausner’s ratio and Carr’s Index were used to evaluate the fl owability and compressibility of the formulation powders during the pre-compression investigations, while, thickness, hardness, weight variation, friability, drug content, for prepared tablets. Results: The results revealed that SD9 at ratio (1:4 glimepiride: soluplus) was the optimal formula since 94% of drug released at 2 hours for immediate layer formula 24, which included ethylcellulose polymer in a 1:1 ratio in the sustained layer of the tablet, was chosen as the optimal formula out of another formula (F1–F28), This formula demonstrated acceptable sustained properties of the glimepiride over the course of 12 hours. and approximately 96% of the medication was released. Conclusion: This study succussed in designing bilayer tablets containing glimepiride solid dispersion formulation in the fi rst immediate release layer and untreated pure drug formulation in the second layer for sustaining the release of the drug for a specifi c period of time to be used as the eff ective treatment of type II diabetes mellitus.
Association of Infl ammatory Bowel Disease and Tumor Necrosis Factor-863 C/A Polymorphism in Iraq
Authors: Hussian Sali E , Mahood Wafaa S
Published: April 2023

Background: The underlying causes of infl ammatory bowel disease (IBD) are unknown, but they are thought to be a combination of genetics, environmental factors, abnormal immune responses, and disruption of the gut microbiota. This study aims to investigate the eff ect of tumor necrosis factor-alpha (TNF-α) -863 C/A(rs 1800630) single nucleotide polymorphism (SNP) in infl ammatory bowel patients and it is relation with the patient’s clinical characteristics. Methods: The study was conducted on 74 blood samples from patients of IBD including 47 patients with ulcerative colitis (UC) and 27 patients with Crohn’s disease (CD) in addition to 20 blood samples apparently healthy individuals, TNF-α-863 C>A genotype was screened by PCR and Sanger sequencing techniques. Results: The results showed that the homozygous CC genotype frequency was the higher genotype frequency in 45/60 (75%) for IBD patients with less than 50 years ages compared with 7/14 (50%) the IBD patients with more than 50 years, signifi cant high association OD (CI): 2.75 (1.38–4.08), The allelic C frequency in ulcerative colitis (UC) patients was (0.83) and signifi cantly higher than the A allele frequency (0.17) and it may act as risk factor infl ammatory disease. The homozygous CC genotype of the TNF-α-863 gene was 9/27 (70.37%) in CD patients compared with 6/20 (30%) in the control group with high signifi cant diff erences (p ≤ 0.01, OR=1.00). Signifi cant diff erences also applied for the heterozygous CA genotype in -863 SNP,it was 8/27 (29.62%) compared with the control group 14/20 (70%) the odds ratio (2.62), while the homozygous AA genotype frequency showed no signifi cant association with CD (p -1.00). Conclusion: The frequency of homozygous CC genotype of the TNF-α-863 gene was higer in CD patients than in the control group with signifi cant diff erences. Signifi cant diff erences also applied for the heterozygous CA genotype while the three genotypes (CC, CA and AA) of the TNF-α-863 gene showed non-signifi cant diff erences in ulcerative patients in comparison with the control.