bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating and analyzing student labor literacy in China's higher vocational education: an assessment model approach
Authors: Wu Suhan , Duan Jingyi , Luo Min
Published: February 2024

Introduction

This study addresses the gap in evaluating labor literacy amongst vocational students in China's higher vocational education system. It aims to develop a comprehensive framework for assessing essential labor competencies, thereby contributing to a nuanced understanding of vocational education's role in skill development.

Methods

Employing a multifaceted research methodology, this study integrates questionnaire surveys, econometric analyses, and the Delphi method to assess labor literacy among 749 students from three leading vocational institutions. A pioneering labor literacy assessment model is introduced: S = 0.5466B1+0.1816B2+0.1623B3+0.1095B4, where S denotes the overall labor literacy score. Here, B1 represents labor concepts, B2 denotes habits and qualities, B3 signifies knowledge and skills, and B4 encapsulates emotions and attitudes, illustrating a comprehensive approach to measuring labor literacy.

Results

Our findings reveal pronounced disparities in labor literacy across the identified dimensions, with particular deficiencies in labor concepts. The study also identifies six determinants—gender, political profile, academic performance, internship and training base utilization, inclination towards innovation and entrepreneurship, and labor education evaluation mechanisms—that significantly influence labor literacy outcomes.

Discussion

Highlighting the imperative for a contextually informed and holistic approach to labor literacy, this study's insights advocate for educational strategies that are both aligned with labor market demands and cognizant of socio-cultural nuances. The developed assessment model not only propels the theoretical discourse in vocational education forward but also provides a pragmatic guide for educators and policy makers, aiming to mitigate disparities and enhance labor competencies through refined educational practices.
Children with idiopathic short stature have significantly different gut microbiota than their normal height siblings: a case-control study
Authors: Lazar Liora , Eshel Adi , Moadi Lelyan , Yackobovitch-Gavan Michal , Bar-Maisels Meytal , Shtaif Biana , Nevo Michal , Phillip Moshe , Turjeman Sondra , Koren Omry , Gat-Yablonski Galia
Published: February 2024

Objectives

To investigate the role of gut microbiota (GM) in pathogenesis of idiopathic short stature (ISS) by comparing GM of ISS children to their normal-height siblings.

Methods

This case-control study, conducted at the Schneider Children’s Medical Center’s Institute for Endocrinology and Diabetes between 4/2018-11/2020, involved 30 pairs of healthy pre-pubertal siblings aged 3-10 years, each comprising one sibling with ISS and one with normal height. Outcome measures from fecal analysis of both siblings included GM composition analyzed by 16S rRNA sequencing, fecal metabolomics, and monitoring the growth of germ-free (GF) mice after fecal transplantation.

Results

Fecal analysis of ISS children identified higher predicted levels of genes encoding enzymes for pyrimidine, purine, flavin, coenzyme B, and thiamine biosynthesis, lower levels of several amino acids, and a significantly higher prevalence of the phylum Euryarchaeota compared to their normal-height siblings (p<0.001). ISS children with higher levels of Methanobrevibacter, the dominant species in the archaeal gut community, were significantly shorter in stature than those with lower levels (p=0.022). Mice receiving fecal transplants from ISS children did not experience stunted growth, probably due to the eradication of Methanobrevibacter caused by exposure to oxygen during fecal collection.

Discussion

Our findings suggest that different characteristics in the GM may explain variations in linear growth. The varying levels of Methanobrevibacter demonstrated within the ISS group reflect the multifactorial nature of ISS and the potential ability of the GM to partially explain growth variations. The targeting of specific microbiota could provide personalized therapies to improve growth in children with ISS.
Stackelberg game-based optimal electricity trading method for distribution networks with small-micro industrial parks
Authors: Chen Liyuan , Ye Qingquan , Wu Xuguang , Chen Yundi , Wang Wanhuan
Published: February 2024

In order to improve the operating benefits of the distribution network (DN) and reduce the energy consumption costs of small-micro industrial parks (SMIPs), a two-layer optimal electricity trading method for DN with SMIPs is proposed. First, based on the Stackelberg game, a multi-objective two-layer optimal trading model for DN and SMIP is established. In the upper layer, the DN agent is regarded as the leader, and a trading model is established with the goal of maximizing the profits of agents. In the lower layer, an energy optimization model is proposed for the SMIP operators, which are regarded as the followers, with the goal of minimizing the operating costs. According to the buying and selling electricity prices at the upper and lower layers, a dynamic pricing strategy is formulated. The Karush–Kuhn–Tucker condition (KKT) is introduced to transform the two-layer model into a single-layer model, and based on linear transformations, the model is further converted into a mixed-integer linear programming model. The transformations aim to address the non-linear issues arising from multivariable coupling between the upper and lower-layer trading models. The simulation results show that the trading strategy proposed in this paper can effectively increase the profit of DNs while reducing the operating costs of SMIPs and can provide a reference for decision-making in the electricity market (EM) with the participation of SMIP.
DeepCBS: shedding light on the impact of mutations occurring at CTCF binding sites
Authors: Wang Yiheng , Guo Xingli , Niu Zhixin , Huang Xiaotai , Wang Bingbo , Gao Lin
Published: February 2024

CTCF-mediated chromatin loops create insulated neighborhoods that constrain promoter-enhancer interactions, serving as a unit of gene regulation. Disruption of the CTCF binding sites (CBS) will lead to the destruction of insulated neighborhoods, which in turn can cause dysregulation of the contained genes. In a recent study, it is found that CTCF/cohesin binding sites are a major mutational hotspot in the cancer genome. Mutations can affect CTCF binding, causing the disruption of insulated neighborhoods. And our analysis reveals a significant enrichment of well-known proto-oncogenes in insulated neighborhoods with mutations specifically occurring in anchor regions. It can be assumed that some mutations disrupt CTCF binding, leading to the disruption of insulated neighborhoods and subsequent activation of proto-oncogenes within these insulated neighborhoods. To explore the consequences of such mutations, we develop DeepCBS, a computational tool capable of analyzing mutations at CTCF binding sites, predicting their influence on insulated neighborhoods, and investigating the potential activation of proto-oncogenes. Futhermore, DeepCBS is applied to somatic mutation data of liver cancer. As a result, 87 mutations that disrupt CTCF binding sites are identified, which leads to the identification of 237 disrupted insulated neighborhoods containing a total of 135 genes. Integrative analysis of gene expression differences in liver cancer further highlights three genes: ARHGEF39, UBE2C and DQX1. Among them, ARHGEF39 and UBE2C have been reported in the literature as potential oncogenes involved in the development of liver cancer. The results indicate that DQX1 may be a potential oncogene in liver cancer and may contribute to tumor immune escape. In conclusion, DeepCBS is a promising method to analyze impacts of mutations occurring at CTCF binding sites on the insulator function of CTCF, with potential extensions to shed light on the effects of mutations on other functions of CTCF.
Janus kinase inhibitors in atopic dermatitis: an umbrella review of meta-analyses
Authors: He Qingying , Xie Xin , Chen Qian , Li Wenquan , Song Zongzhou , Wang Xurui , Ma Xiao , Zeng Jinhao , Guo Jing
Published: February 2024

Background

Clinicians and healthcare policymakers have been drenched with a deluge of overlapping meta-analyses (MAs), and the necessity for comprehensive and clearly defined evidence of Janus kinase inhibitors (JKIs) in atopic dermatitis (AD) is urgent.

Methods

Six databases were searched for MAs published until October 2023. Qualitative description of MAs was mainly used, and Investigator's Global Assessment response (IGA response), the 75% improvement in Eczema Area and Severity Index (the EASI75), peak pruritus Numerical rating score (PP-NRS), and adverse effects were cited to describe the efficacy and safety of JKIs. The methodological quality of the included MAs was assessed by A Measurement Tool to Assess Systematic Reviews II (AMSTAR II), and the quality of evidence was evaluated by the grading of recommendations, assessment, development, and evaluation (GRADE).

Results

Sixteen MAs were pooled in this review, of which five studies appraised JKIs, five appraised systemic JKIs, five papers assessed abrocitinib only, and one assessed baricitinib. Two studies were of “high” methodological quality and 14 MAs were of “moderate” quality. Eleven MAs integrated the results of JKIs and reported that JKIs provide faster onset of IGA response (RR=2.83, 95% CI [2.25, 3.56], high-quality evidence). Similarly, 10 MAs showed that JAK inhibitors were more effective in improving the EASI75 (RR=2.84, 95% CI [2.2, 3.67], high-quality evidence). Results from 12 MAs showed JKIs were active in reducing the PP-NRS (SMD=-0.49, 95% CI [-0.67, -0.32]). All MAs affirmed JKIs added no adverse effects leading to discontinuation and serious adverse events (P<0.05). However, 200mg of abrocitinib had a higher risk of acne (RR=4.34, 95% CI [1.61, 11.71), herpes zoster (RR=1.64, 95% CI [0.42, 6.39]), headache (RR=1.76, 95% CI [1.03, 3]), and nausea (RR=7.81, 95% CI [3.84, 15.87]). Upadacitinib was known to increase acne (RR=6.23, 95% CI [4.08, 9.49]), nasopharyngitis (RR=1.36, 95% CI [1.03, 1.8]) and blood creatine phosphokinase (blood CPK) (RR=2.41, 95% CI [1.47, 3.95]). Baricitinib at 2mg was associated with increased blood CPK (RR=2.25, 95% CI [1.1, 2.97]).

Conclusion

Compared to placebo or dupilumab, the administration of JKIs can ameliorate IGA response more effectively, improve the EASI75, and relieve pruritus without severe adverse effect, while accompanied by more acne, nasopharyngitis, headache, and digestive disturbances. The curative effect of 200 mg of abrocitinib is significant and more caution should be given in patients with gastrointestinal dysfunction, herpes zoster, and those who are acne-prone. Baricitinib and upadacitinib should be avoided in populations at high risk for cardiovascular events.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=369369, PROSPERO (CRD42022369369).
Prognostic impact of clinical factors for immune checkpoint inhibitor with or without chemotherapy in older patients with non-small cell lung cancer and PD-L1 TPS ≥ 50%
Authors: Takei Shota , Kawachi Hayato , Yamada Tadaaki , Tamiya Motohiro , Negi Yoshiki , Goto Yasuhiro , Nakao Akira , Shiotsu Shinsuke , Tanimura Keiko , Takeda Takayuki , Okada Asuka , Harada Taishi , Date Koji , Chihara Yusuke , Hasegawa Isao , Tamiya Nobuyo , Katayama Yuki , Nishioka Naoya , Morimoto Kenji , Iwasaku Masahiro , Tokuda Shinsaku , Kijima Takashi , Takayama Koichi
Published: February 2024

Introduction

The proportion of older patients diagnosed with advanced-stage non-small cell lung cancer (NSCLC) has been increasing. Immune checkpoint inhibitor (ICI) monotherapy (MONO) and combination therapy of ICI and chemotherapy (COMBO) are standard treatments for patients with NSCLC and programmed cell death ligand-1 (PD-L1) tumor proportion scores (TPS) ≥ 50%. However, evidence from the clinical trials specifically for older patients is limited. Thus, it is unclear which older patients benefit more from COMBO than MONO.

Methods

We retrospectively analyzed 199 older NSCLC patients of Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1 and PD-L1 TPS ≥ 50% who were treated with MONO or COMBO. We analyzed the association between treatment outcomes and baseline patient characteristics in each group, using propensity score matching.

Results

Of the 199 patients, 131 received MONO, and 68 received COMBO. The median overall survival (OS; MONO: 25.2 vs. COMBO: 42.2 months, P = 0.116) and median progression-free survival (PFS; 10.9 vs. 11.8 months, P = 0.231) did not significantly differ between MONO and COMBO group. In the MONO group, OS was significantly shorter in patients without smoking history compared to those with smoking history [HR for smoking history against non-smoking history: 0.36 (95% CI: 0.16-0.78), P = 0.010]. In the COMBO group, OS was significantly shorter in patients with PS 1 than those with PS 0 [HR for PS 0 against PS 1: 3.84 (95% CI: 1.44-10.20), P = 0.007] and for patients with squamous cell carcinoma (SQ) compared to non-squamous cell carcinoma (non-SQ) [HR for SQ against non-SQ: 0.17 (95% CI: 0.06-0.44), P < 0.001]. For patients with ECOG PS 0 (OS: 26.1 months vs. not reached, P = 0.0031, PFS: 6.5 vs. 21.7 months, P = 0.0436) or non-SQ (OS: 23.8 months vs. not reached, P = 0.0038, PFS: 10.9 vs. 17.3 months, P = 0.0383), PFS and OS were significantly longer in the COMBO group.

Conclusions

ECOG PS and histological type should be considered when choosing MONO or COMBO treatment in older patients with NSCLC and PD-L1 TPS ≥ 50%.
A brief review of the current status of pig islet xenotransplantation
Authors: Cooper David K. C. , Mou Lisha , Bottino Rita
Published: February 2024

An estimated 1.5 million Americans suffer from Type I diabetes mellitus, and its incidence is increasing worldwide. Islet allotransplantation offers a treatment, but the availability of deceased human donor pancreases is limited. The transplantation of islets from gene-edited pigs, if successful, would resolve this problem. Pigs are now available in which the expression of the three known xenoantigens against which humans have natural (preformed) antibodies has been deleted, and in which several human ‘protective’ genes have been introduced. The transplantation of neonatal pig islets has some advantages over that of adult pig islets. Transplantation into the portal vein of the recipient results in loss of many islets from the instant blood-mediated inflammatory reaction (IBMIR) and so the search for an alternative site continues. The adaptive immune response can be largely suppressed by an immunosuppressive regimen based on blockade of the CD40/CD154 T cell co-stimulation pathway, whereas conventional therapy (e.g., based on tacrolimus) is less successful. We suggest that, despite the need for effective immunosuppressive therapy, the transplantation of ‘free’ islets will prove more successful than that of encapsulated islets. There are data to suggest that, in the absence of rejection, the function of pig islets, though less efficient than human islets, will be sufficient to maintain normoglycemia in diabetic recipients. Pig islets transplanted into immunosuppressed nonhuman primates have maintained normoglycemia for periods extending more than two years, illustrating the potential of this novel form of therapy.
Urinary liver-type fatty acid-binding protein levels may be associated with the occurrence of acute kidney injury induced by trauma
Authors: Yasuda Ryu , Suzuki Keiko , Okada Hideshi , Ishihara Takuma , Minamiyama Toru , Kamidani Ryo , Kitagawa Yuichiro , Fukuta Tetsuya , Suzuki Kodai , Miyake Takahito , Yoshida Shozo , Tetsuka Nobuyuki , Ogura Shinji
Published: February 2024

Introduction

Acute kidney injury (AKI), with a fatality rate of 8.6%, is one of the most common types of multiorgan failure in the intensive care unit (ICU). Thus, AKI should be diagnosed early, and early interventions should be implemented. Urinary liver-type fatty acid-binding protein (L-FABP) could aid in the diagnosis of AKI.

Methods

In this prospective, single-center, observational study, we included 100 patients with trauma. Urinary L-FABP levels were measured using a semi-quantitative rapid assay kit 6 and 12 h after injury. Negative, weakly positive, and strongly positive urinary L-FABP levels were examined using two protocols. Using protocol 1, measurements were performed at 6 h after injury negative levels were considered “negative,” and weakly positive and strongly positive levels were considered “positive.” Using protocol 2, strongly positive levels at 6 h after injury were considered “positive,” and negative or weakly positive levels at 6 h after injury were considered “positive” if they were weakly positive or positive at 12 h after injury.

Results

Fifteen patients were diagnosed with AKI. Using protocol 1, the odds ratio (OR) was 20.55 (p = 0.001) after adjustment for the injury severity score (ISS), contrast media use, and shock index. When the L-FABP levels at 6 and 12 h were similarly adjusted for those three factors, the OR was 18.24 (p < 0.001). The difference in ORs for protocols 1 and 2 was 1.619 (p = 0.04).

Discussion

Associations between urinary L-FABP and AKI can be examined more precisely by performing measurements at 6 and 12 h after injury than only one time at 6 h.
Combining metabolic flux analysis with proteomics to shed light on the metabolic flexibility: the case of Desulfovibrio vulgaris Hildenborough
Authors: Marbehan Xavier , Roger Magali , Fournier Frantz , Infossi Pascale , Guedon Emmanuel , Delecourt Louis , Lebrun Régine , Giudici-Orticoni Marie-Thérèse , Delaunay Stéphane
Published: February 2024

Introduction

Desulfovibrio vulgaris Hildenborough is a gram-negative anaerobic bacterium belonging to the sulfate-reducing bacteria that exhibits highly versatile metabolism. By switching from one energy mode to another depending on nutrients availability in the environments„ it plays a central role in shaping ecosystems. Despite intensive efforts to study D. vulgaris energy metabolism at the genomic, biochemical and ecological level, bioenergetics in this microorganism remain far from being fully understood. Alternatively, metabolic modeling is a powerful tool to understand bioenergetics. However, all the current models for D. vulgaris appeared to be not easily adaptable to various environmental conditions.

Methods

To lift off these limitations, here we constructed a novel transparent and robust metabolic model to explain D. vulgaris bioenergetics by combining whole-cell proteomic analysis with modeling approaches (Flux Balance Analysis).

Results

The iDvu71 model showed over 0.95 correlation with experimental data. Further simulations allowed a detailed description of D. vulgaris metabolism in various conditions of growth. Altogether, the simulations run in this study highlighted the sulfate-to-lactate consumption ratio as a pivotal factor in D. vulgaris energy metabolism.

Discussion

In particular, the impact on the hydrogen/formate balance and biomass synthesis is discussed. Overall, this study provides a novel insight into D. vulgaris metabolic flexibility.
Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via exosomes in gastrointestinal tumors
Authors: Cao Longyang , Ouyang Hong
Published: February 2024

Gastrointestinal (GI) tumors are a significant global health threat, with high rates of morbidity and mortality. Exosomes contain various biologically active molecules like nucleic acids, proteins, and lipids and can serve as messengers for intercellular communication. They play critical roles in the exchange of information between tumor cells and the tumor microenvironment (TME). The TME consists of mesenchymal cells and components of the extracellular matrix (ECM), with fibroblasts being the most abundant cell type in the tumor mesenchyme. Cancer-associated fibroblasts (CAFs) are derived from normal fibroblasts and mesenchymal stem cells that are activated in the TME. CAFs can secrete exosomes to modulate cell proliferation, invasion, migration, drug resistance, and other biological processes in tumors. Additionally, tumor cells can manipulate the function and behavior of fibroblasts through direct cell-cell interactions. This review provides a summary of the intercellular crosstalk between GI tumor cells and CAFs through exosomes, along with potential underlying mechanisms.
Magnetic resonance imaging based kidney volume assessment for risk stratification in pediatric autosomal dominant polycystic kidney disease
Authors: Yilmaz Kubra , Saygili Seha , Canpolat Nur , Akgun-Dogan Ozlem , Yuruk Yildirim Zeynep Nagehan , Cicek-Oksuz Rumeysa Yasemin , Oner Huseyin Adil , Aksu Bagdagul , Akyel Nazli Gulsum , Oguzhan-Hamis Ozge , Dursun Hasan , Yavuz Sevgi , Cicek Neslihan , Akinci Nurver , Karabag Yilmaz Esra , Agbas Ayse , Nayir Ahmet Nevzat , Konukoglu Dildar , Kurugoglu Sebuh , Sever Lale , Caliskan Salim
Published: February 2024

Introduction

In the pediatric context, most children with autosomal dominant polycystic kidney disease (ADPKD) maintain a normal glomerular filtration rate (GFR) despite underlying structural kidney damage, highlighting the critical need for early intervention and predictive markers. Due to the inverse relationship between kidney volume and kidney function, risk assessments have been presented on the basis of kidney volume. The aim of this study was to use magnetic resonance imaging (MRI)-based kidney volume assessment for risk stratification in pediatric ADPKD and to investigate clinical and genetic differences among risk groups.

Methods

This multicenter, cross-sectional, and case-control study included 75 genetically confirmed pediatric ADPKD patients (5–18 years) and 27 controls. Kidney function was assessed by eGFR calculated from serum creatinine and cystatin C using the CKiD-U25 equation. Blood pressure was assessed by both office and 24-hour ambulatory measurements. Kidney volume was calculated from MRI using the stereological method. Total kidney volume was adjusted for the height (htTKV). Patients were stratified from A to E classes according to the Leuven Imaging Classification (LIC) using MRI-derived htTKV.

Results

Median (Q1-Q3) age of the patients was 6.0 (2.0–10.0) years, 56% were male. There were no differences in sex, age, height-SDS, or GFR between the patient and control groups. Of the patients, 89% had PKD1 and 11% had PKD2 mutations. Non-missense mutations were 73% in PKD1 and 75% in PKD2. Twenty patients (27%) had hypertension based on ABPM. Median htTKV of the patients was significantly higher than controls (141 vs. 117 ml/m, p = 0.0003). LIC stratification revealed Classes A (38.7%), B (28%), C (24%), and D + E (9.3%). All children in class D + E and 94% in class C had PKD1 variants. Class D + E patients had significantly higher blood pressure values and hypertension compared to other classes (p > 0.05 for all).

Discussion

This study distinguishes itself by using MRI-based measurements of kidney volume to stratify pediatric ADPKD patients into specific risk groups. It is important to note that PKD1 mutation and elevated blood pressure were higher in the high-risk groups stratified by age and kidney volume. Our results need to be confirmed in further studies.
The neurological wake-up test in severe pediatric traumatic brain injury: a long term, single-center experience
Authors: Mulder Hilde D. , Helfferich Jelte , Kneyber Martin C. J.
Published: February 2024

Objectives

To describe the use and outcomes of the neurological wake-up test (NWT) in pediatric severe traumatic brain injury (pTBI).

Design

Retrospective single-center observational cohort study.

Setting

Medical-surgical tertiary pediatric intensive care unit (PICU) in a university medical center and Level 1 Trauma Center.

Patients

Children younger than 18 years with severe TBI [i.e., Glasgow Coma Scale (GCS) of ≤8] admitted between January 2010 and December 2020. Subjects with non-traumatic brain injury were excluded.

Measurements and main results

Of 168 TBI patients admitted, 36 (21%) met the inclusion criteria. Median age was 8.5 years [2 months to 16 years], 5 patients were younger than 6 months. Median initial Glasgow Coma Scale (GCS) and Glasgow Motor Scale (GMS) was 6 [3–8] and 3 [1–5]. NWTs were initiated in 14 (39%) patients, with 7 (50%) labelled as successful. Fall from a height was the underlying injury mechanism in those seven. NWT-failure occurred in patients admitted after traffic accidents. Sedation use in both NWT-subgroups (successful vs. failure) was comparable. Cause of NWT-failure was non-arousal (71%) or severe agitation (29%). Subjects with NWT failure subsequently had radiological examination (29%), repeat NWT (43%), continuous interruption of sedation (14%) or intracranial pressure (ICP) monitoring (14%). The primary reason for not doing NWTs was intracranial hypertension in 59%. Compared to the NWT-group, the non-NWT group had a higher PRISM III score (18.9 vs. 10.6), lower GCS/GMS at discharge, more associated trauma, and circulatory support. Nine patients (25%) died during their PICU admission, none of them had an NWT.

Conclusion

We observed limited use of NWTs in pediatric severe TBI. Patients who failed the NWT were indistinguishable from those without NWT. Both groups were more severely affected compared to the NWT successes. Therefore, our results may indicate that only a select group of severe pTBI patients qualify for the NWT.
Associations between prematurity, postpartum anxiety, neonatal intensive care unit admission, and stress
Authors: Worrall Semra , Christiansen Paul , Khalil Asma , Silverio Sergio A. , Fallon Victoria
Published: February 2024

Introduction

It is well established that a premature birth increases the likelihood of developing anxiety during the postpartum period, and that the environment of the neonatal intensive care unit (NICU) might be a contributing factor. Mothers of earlier premature infants may experience these anxieties to a higher degree compared to mothers of later premature infants. The aim of this study was to explore the association between prematurity and postpartum-specific anxiety, and the relationship between postpartum-specific anxiety and stress in the NICU.

Materials and methods

Mothers (N = 237) of infants aged between birth and 12 months completed an online survey containing the Postpartum Specific Anxiety Scale – Research Short Form (PSAS-RSF) and the Parental Stressor Scale: Neonatal Intensive Care Unit (PSS:NICU). Structural equation modeling was used to analyze the relationship between gestational age and postpartum-specific anxiety, with one-way ANOVAs used to analyze this relationship with respect to categories of gestational age. Hierarchical regression models analyzed the relationship between postpartum-specific anxiety and stress in the NICU.

Results

For the PSAS-RSF, Practical Infant Care Anxieties (p = 0.001), Maternal Competence and Attachment Anxieties (p = 0.033), and Infant Safety and Welfare Anxieties (p = 0.020) were significantly associated with week of gestation. Practical Infant Care and Infant Safety and Welfare Anxieties were significantly higher for mothers of late premature infants, compared to mothers of term infants (p < 0.001; p = 0.019). There were no significant between-group differences with respect to Maternal Competence and Attachment Anxieties. After controlling for potential confounders, Infant Safety and Welfare Anxieties were significantly associated with increased stress in the NICU (p < 0.001) as measured by the PSS:NICU.

Conclusions

Our findings highlight the need for interventions for mothers with premature infants, which specifically target anxieties reflected in the PSAS-RSF, such as routine care and increasing maternal self-efficacy.
A Delphi consensus on clinical features, diagnosis and treatment of major depressive disorder patients with anhedonia amongst psychiatrists in the Asia-Pacific
Authors: Cheng Calvin , Herr Keira , Jeon Hong Jin , Kato Tadafumi , Ng Chee H. , Yang Yen Kuang , Zhang Ling
Published: February 2024

Background

Anhedonia, a core diagnostic feature for major depressive disorder (MDD), is defined as the loss of pleasure and interest in daily activities. Its prevalence in MDD patients vary from 35 to 70%. Anhedonia in MDD negatively impacts functioning and is associated with treatment resistance and poorer prognosis for various clinical outcomes. Owing to its complexity, there remains considerable heterogeneity in the conceptualization, diagnosis and clinical management of anhedonia in MDD.

Methods

This modified Delphi panel was conducted to elicit expert opinion and establish consensus on concepts relating to clinical features, diagnosis and treatment of MDD with anhedonia (MDDwA) amongst psychiatrists in the Asia-Pacific region. Seven themes were covered. A three-stage process was adopted for consensus generation (two online survey rounds, followed by a moderated consensus meeting). Statements were developed based on a literature review and input from a steering committee of six regional experts. The panel included 12 psychiatrists practicing in Australia, China, Hong Kong, Japan, South Korea and Taiwan with ≥5 years of specialist clinical experience, including assessment or management of patients with MDDwA.

Results

Overall, consensus was achieved (median ≥8) on 89/103 statements (86%). About half of the statements (55/103, 53%) achieved consensus in Round 1, and 29/36 modified statements achieved consensus in Round 2. At the moderated consensus meeting, five modified statements were discussed by the steering committee and consensus was achieved on all statements (5/5). The findings highlighted a lack of clear and practical methods in clinical practice for assessing anhedonia in MDD patients and limited physician awareness of anhedonia in Asia-Pacific.

Conclusion

Insights from this Delphi consensus provide a reference point for psychiatrists in Asia-Pacific to optimize their strategies for personalized diagnosis and management of patients with MDDwA. Identification of distinct and clinically relevant subtypes in MDD may be valuable for guiding personalized diagnosis and management approaches, including type-specific therapies.
Prevalence and associated factors of depression, anxiety and stress among clinical therapists in China in the context of early COVID-19 pandemic
Authors: Tao Rui , Li Wenzheng , Min Kaiyuan , Mo Daming , Geng Feng , Xia Lei , Liu Tingfang , Liu Yuanli , Jiang Feng , Liu Huanzhong , Tang Yi-lang
Published: February 2024

Objectives

To study the socio-demographic characteristics and the prevalence of depression, anxiety, and stress among clinical therapists in China during the early Coronavirus disease 2019 (COVID-19) pandemic and to identify associated factors.

Method

This cross-sectional study was part of a multicenter, nationally representative survey conducted through WeChat from January 2021 to March 2021. Data, including socio-demographics, health-related behaviors, and information on whether they participated in the frontline work of treating COVID-19, were collected anonymously. Respondents also completed the Depression Anxiety Stress Scales-21 (DASS-21).

Results

In total, 396 clinical therapists in the selected hospitals completed the questionnaires, with a response rate of 89.0%. Respondents were predominantly female (77.3%). About 6.6% of the participants were current tobacco users, and 20.7% had participated in the frontline work of treating COVID-19. Overall, 22.0%, 17.9%, and 8.8% of participants were classified as having clinically meaningful depression, anxiety, and stress, respectively, based on DASS-21 scores. Multiple logistic regression in Model 1 and Model 2 showed that depression, anxiety, and stress were associated with regular physical activity and frequent insomnia (all, p < 0.05). In anxiety model 2, the associated factors for anxiety during the pandemic were identified as education (master’s degree or more, OR=0.520; 95% CI=0.283-0.955), marital status (single, OR=2.064; 95% CI=1.022-4.168), tobacco use (OR=4.265; 95% CI=1.352-13.454), regular physical activity (OR=0.357; 95% CI=0.192-0.663), frequent insomnia (OR=6.298; 95% CI =2.522-15.729), and participation in the frontline work of treating COVID-19 (OR=3.179; 95% CI=1.697-5.954). The COVID-19 epidemic did not significantly increase the depression and stress levels among clinical therapists, but it did significantly increase anxiety levels.

Conclusion

During the COVID-19 pandemic, depression, anxiety and stress were relatively common among clinical therapists in China. Regular physical activity and good sleep were important protective factors against emotional problems. Therefore, encouraging regular physical activity and actively addressing clinical therapists’ sleep problems is beneficial to improving the ability to cope with negative emotions. The COVID-19 epidemic significantly increased anxiety, and awareness and interventions should be recommended to reduce anxiety among clinical therapists during the COVID-19 pandemic.
Immunogenicity of RV1 and RV5 vaccines administered in standard and interchangeable mixed schedules: a randomized, double-blind, non-inferiority clinical trial in Mexican infants
Authors: Macías-Parra Mercedes , Vidal-Vázquez Patricia , Reyna-Figueroa Jesús , Rodríguez-Weber Miguel Ángel , Moreno-Macías Hortensia , Hernández-Benavides Inés , Fortes-Gutiérrez Sofía , Richardson Vesta Louise , Vázquez-Cárdenas Paola
Published: February 2024

Introduction

Rotavirus-associated diarrheal diseases significantly burden healthcare systems, particularly affecting infants under five years. Both Rotarix™ (RV1) and RotaTeq™ (RV5) vaccines have been effective but have distinct application schedules and limited interchangeability data. This study aims to provide evidence on the immunogenicity, reactogenicity, and safety of mixed RV1-RV5 schedules compared to their standard counterparts.

Methods

This randomized, double-blind study evaluated the non-inferiority in terms of immunogenicity of mixed rotavirus vaccine schedules compared to standard RV1 and RV5 schedules in a cohort of 1,498 healthy infants aged 6 to 10 weeks. Participants were randomly assigned to one of seven groups receiving various combinations of RV1, and RV5. Standard RV1 and RV5 schedules served as controls of immunogenicity, reactogenicity, and safety analysis. IgA antibody levels were measured from blood samples collected before the first dose and one month after the third dose. Non-inferiority was concluded if the reduction in seroresponse rate in the mixed schemes, compared to the standard highest responding scheme, did not exceed the non-inferiority margin of −0.10. Reactogenicity traits and adverse events were monitored for 30 days after each vaccination and analyzed on the entire cohort.

Results

Out of the initial cohort, 1,365 infants completed the study. Immunogenicity analysis included 1,014 infants, considering IgA antibody titers ≥20 U/mL as seropositive. Mixed vaccine schedules demonstrated non-inferiority to standard schedules, with no significant differences in immunogenic response. Safety profiles were comparable across all groups, with no increased incidence of serious adverse events or intussusception.

Conclusion

The study confirms that mixed rotavirus vaccine schedules are non-inferior to standard RV1 and RV5 regimens in terms of immunogenicity and safety. This finding supports the flexibility of rotavirus vaccination strategies, particularly in contexts of vaccine shortage or logistic constraints. These results contribute to the global effort to optimize rotavirus vaccination programs for broader and more effective pediatric coverage.

Clinical trial registration: ClinicalTrials.gov, NCT02193061.
Research progress on and molecular mechanism of vacuum sealing drainage in the treatment of diabetic foot ulcers
Authors: Lu Yongpan , Zhao Dejie , Cao Guoqi , Yin Siyuan , Liu Chunyan , Song Ru , Ma Jiaxu , Sun Rui , Wu Zhenjie , Liu Jian , Wu Peng , Wang Yibing
Published: February 2024

Diabetic foot ulcers (DFUs) are common chronic wounds and a common complication of diabetes. The foot is the main site of diabetic ulcers, which involve small and medium-sized arteries, peripheral nerves, and microcirculation, among others. DFUs are prone to coinfections and affect many diabetic patients. In recent years, interdisciplinary research combining medicine and material science has been increasing and has achieved significant clinical therapeutic effects, and the application of vacuum sealing drainage (VSD) in the treatment of DFUs is a typical representative of this progress, but the mechanism of action remains unclear. In this review, we integrated bioinformatics and literature and found that ferroptosis is an important signaling pathway through which VSD promotes the healing of DFUs and that System Xc-GSH-GPX4 and NAD(P)H-CoQ10-FSP1 are important axes in this signaling pathway, and we speculate that VSD is most likely to inhibit ferroptosis to promote DFU healing through the above axes. In addition, we found that some classical pathways, such as the TNF, NF-κB, and Wnt/β-catenin pathways, are also involved in the VSD-mediated promotion of DFU healing. We also compiled and reviewed the progress from clinical studies on VSD, and this information provides a reference for the study of VSD in the treatment of DFUs.
Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota
Authors: Guan Yuling , Zheng Wendan , Bai Yu , Wu Bo
Published: February 2024

Introduction

Yupingfeng polysaccharide (YPF-P) is the main substance of alcohol deposition in Yupingfeng powder, which has many biological functions such as enhancing immunity, repairing intestinal barrier and enhancing antioxidant ability. This study employed in vitro growth-promoting drug feed additives and animal experiments to comprehensively evaluate the use of YPF-P in broiler production.

Methods

A total of 1,296 151 days-old Qingyuan Partridge chickens were randomly divided into four groups with six replicates and 54 hens per replicate: the control group was fed basal diet, and the experimental groups were fed diets supplemented with 4 g/kg, 8 g/kg, and 12 g/kg YPF-P for 14 days. Broilers were weighed before and at the end of the experiment to calculate total weight gain (GW), average daily gain (ADG), and feed compensation. At the end of the experiment, six chickens from each group were randomly selected for subwing vein blood sampling, which was used to measure serum biochemical indicators GHRH, GH, and IGF-1 by ELISA method. Randomly select chickens from control group and 8 g/kg group for slaughter, and cecal contents were collected for 16S high-throughput sequencing.

Results

Dietary supplementation of 8 g/kg YPF-P can significantly increase the final body weight, total weight gain, average daily gain and decrease the feed to gain ratio of chickens. During 151–165 days, serum IGF-1 concentrations increased significantly (p < 0.05). There were no significant changes in serum GH concentration (p > 0.05). In terms of gut microbiota, there was no significant difference between control group and test group in Shannon index and Simpson index. Compared with the control group,the addition of 8 g/kgYPF-P significantly increased the abundance of Firmicutes and significantly decreased the abundance of Bacteroides at the phylum level.At the genus level, the relative abundance of unclassified_Oscillospiraceae was significantly increased and the unclassified_Muribaculaceae, uncultured_Bacteroidales_bacterium, Lactobacillus, Alloprevotella, Ligilactobacillus, Prevotellaceae_UCG_001, and unclassified_Atopobiaceae was significantly decreased.

Conclusion

The above results showed that adding 8 mg/kg of YPF-P could increase the average daily gain of Qingyuan Partridge chickens, reduce the ratio of feed to meat, and affect the distribution proportion of intestinal microflora in chickens to some extent.
„Królestwo Regencyjne”. Quasi-monarchistyczny epizod na drodze do Rzeczypospolitej niepodległej
Authors: Jabłonowski Marek , Jakubowski Wojciech , Przastek Daniel
Published: February 2024

The objective of the paper is to indicate selected issues related to the construction of the political system of the future Polish state in 1918. Parallel to the construction of the political system, struggles for independence and the borders of the state, which was reborn after 123 years of captivity, continued. The emergence of centers of power and political institutions in the conditions of geopolitical changes of the last phase of the Great War of 1914–1918 was of utmost importance for the process of shaping the political system. The main links in this process were the Provisional Council of State and the Regency Council.
Prezydent RP jako polityczny przedsiębiorca
Authors: Jagielski Tomasz
Published: February 2024

The aim of this paper is to present the status, role, and the potential for political action of the President of the Republic of Poland analysed through the prism of the concept of the political entrepreneur. I make a diagnosis of the president’s political resources and their potential for the realisation political goals – his formation and his own. The resources of the President can be considered in two categories, i.e. permanent and labile. They are concentrated around the prerogatives held, the political environment, the political capital of the office, and the opportunity structure.
Sprawy zagraniczne w polityce Rady Regencyjnej
Authors: Kornat Marek
Published: February 2024

The proclamation of Polish statehood and the establishment of the Regency Council in 1917 enabled the undertaking of diplomatic activities in the Central Powers to ensure the conditions for the Polish state to be viable. The aim of the paper is to present the construction of the foundations of Polish politics – the diplomacy of the Regency Council administration through its government offices, as well as to seek answers to the questions whether the assumed intentions were implemented and what was the result of initiatives and activities in this area on the international arena?
Rządy Rady Regencyjnej w zasobie Archiwum Akt Nowych
Authors: Janowski Włodzimierz
Published: February 2024

Archives occupy a special place in academic research. The aim of the paper is to present sources for research on the functioning of the Regency Council in the resources of the Archives of New Records in Warsaw (AAN). The documentation collected in the AAN is dispersed (it is stored in several archival units: the Civil Cabinet of the Regency Council, the Presidium of the Council of Ministers, the Ministry of Provisioning, the Ministry of Foreign Affairs, and private files) and most often complements each other. The aforementioned documents allow for the presentation of both the organization of governments, their personnel, as well as the analysis of the “governing process” and the connections between the Regency Council and subordinate institutions, social organizations, and the occupation authorities.
V Republika Francuska wobec dziedzictwa historycznego
Authors: Ujazdowski Kazimierz Michał
Published: February 2024

The historicity of the Constitution of the Fifth French Republic has a special dimension. In the preamble and in the articles of the first Chapter, reference is made to the heritage of the French Revolution and identification with its principles is emphasised. We are therefore dealing with a case of the Constitution that explicitly refers not to the entire historical heritage of France but to an exceptional moment in its history. This reference has a very real meaning because the legacy of the French Revolution affects the constitutional reality of today’s France. This applies in particular to the specially conceive d idea of the sovereignty of the nation, the principles of indivisibility and the secularity of the Republic. At the same time, under the Constitution of the Fifth Republic, there has been an interpretation of the legacy of the Revolution in terms that are critical of the Jacobin tradition, which allowed for a broad consensus on it. On the other hand, it can be argued that the Constitution is not fully representative in the dimension of history, as the legacy of pre-revolutionary France occupies a vital place in public education and in the politics of memory.
La Cinquième République: Forces et faiblesses d’une Constitution à géométrie variable
Authors: Hérin Marie France , Hérin Jean Louis
Published: February 2024

During the celebration of the 65th anniversary of the Fifth Republic, the longevity and vitality of the Constitution was explained by its ability to adapt to all political situations, such as the alternation of right and left or cohabitation. The fundamental issue highlighted by the authors of the study is to guarantee the continuity of public policies and thus the effectiveness of public action. They show the evolution of institutions, the nuances of political practices, raise numerous questions, but do not question the legitimacy of maintaining France’s system under the Fifth Republic.
Development and Practical Applications of Computational Intelligence Technology
Authors: Matsuzaka Yasunari , Yashiro Ryu
Published: February 2024

Computational intelligence (CI) uses applied computational methods for problem-solving inspired by the behavior of humans and animals. Biological systems are used to construct software to solve complex problems, and one type of such system is an artificial immune system (AIS), which imitates the immune system of a living body. AISs have been used to solve problems that require identification and learning, such as computer virus identification and removal, image identification, and function optimization problems. In the body’s immune system, a wide variety of cells work together to distinguish between the self and non-self and to eliminate the non-self. AISs enable learning and discrimination by imitating part or all of the mechanisms of a living body’s immune system. Certainly, some deep neural networks have exceptional performance that far surpasses that of humans in certain tasks, but to build such a network, a huge amount of data is first required. These networks are used in a wide range of applications, such as extracting knowledge from a large amount of data, learning from past actions, and creating the optimal solution (the optimization problem). A new technique for pre-training natural language processing (NLP) software ver.9.1by using transformers called Bidirectional Encoder Representations (BERT) builds on recent research in pre-training contextual representations, including Semi-Supervised Sequence Learning, Generative Pre-Training, ELMo (Embeddings from Language Models), which is a method for obtaining distributed representations that consider context, and ULMFit (Universal Language Model Fine-Tuning). BERT is a method that can address the issue of the need for large amounts of data, which is inherent in large-scale models, by using pre-learning with unlabeled data. An optimization problem involves “finding a solution that maximizes or minimizes an objective function under given constraints”. In recent years, machine learning approaches that consider pattern recognition as an optimization problem have become popular. This pattern recognition is an operation that associates patterns observed as spatial and temporal changes in signals with classes to which they belong. It involves identifying and retrieving predetermined features and rules from data; however, the features and rules here are not logical information, but are found in images, sounds, etc. Therefore, pattern recognition is generally conducted by supervised learning. Based on a new theory that deals with the process by which the immune system learns from past infection experiences, the clonal selection of immune cells can be viewed as a learning rule of reinforcement learning.