bluuebunny/crossref_metadata_2025 huggingface dataset:
Cost-sensitive precomputation of real-time-aware reconfiguration strategies based on stochastic priced timed games
Authors: Göttmann Hendrik , Caesar Birte , Beers Lasse , Lochau Malte , Schürr Andy , Fay Alexander
Published: August 2024

In many recent application domains, software systems must repeatedly reconfigure themselves at runtime to satisfy changing contextual requirements. To decide which next configuration is presumably best suited is a very challenging task as it involves not only functional requirements but also non-functional properties (NFP). NFP include multiple, potentially contradicting, criteria like real-time constraints and cost measures like energy consumption. Effectiveness of context-aware reconfiguration decisions further depends on mostly uncertain future contexts which makes greedy one-step decision heuristics potentially misleading. Moreover, the computational runtime overhead for reconfiguration planning should not nullify the benefits. Nevertheless, entirely pre-planning reconfiguration decisions during design time is also not feasible due to missing knowledge about runtime contexts. In this article, we propose a model-based technique for precomputing context-aware reconfiguration decisions under partially uncertain real-time constraints and cost measures. We employ a game-theoretic approach based on stochastic priced timed game automata as reconfiguration model. This formal model allows us to automatically synthesize winning strategies for the first player (the system) which efficiently delivers presumably best-fitting reconfiguration decisions as reactions to moves of the second player (the context) at runtime. Our tool implementation copes with the high computational complexity of strategy synthesis by utilizing the statistical model checker Uppaal Stratego to approximate near-optimal solutions. We applied our tool to a real-world example consisting of a reconfigurable robot support system for the construction of aircraft fuselages. Our evaluation results show that Uppaal Stratego is indeed able to precompute effective reconfiguration strategies within a reasonable amount of time.
Recognising a kaleidoscopic archive: working with London Missionary Society records in the geekosphere’
Authors: Lee-Talbot Deborah
Published: August 2024

This article is an ultra-reflective account of an encounter with London Missionary Society (LMS) records through the Australian Joint Copying Project (AJCP) collections at the State Library of Victoria (SLV) and the home office as socially and materially informed research spaces. The genealogies of surrogate archives are little analysed, yet they have complex pasts worth investigating. As Jasmine Burns (JALSNA 33: 150–167, 2024), the librarian and metadata specialist explained, information about an archive’s ancestry is valuable as it illuminates the history and a pattern of use beyond the original author’s intent. The subsequent discussion shows how I inspect descriptive categories associated with the AJCP LMS microfilmed and digitised records in the custody of SLV, the London School of Oriental and African Studies (SOAS) and the National Library of Australia, (NLA) showing how meaning was layered onto these records. Extending on the social historian Arlette Farge’s analogy of the archive as a kaleidoscope, I demonstrate the introductory process by which a historian determines absences and presences in the archive and to what extent the initial imperial categories used by archivists and librarians informed my research practices. By analysing the history of the LMS AJCP collection, I demonstrate how these Australian-Pacific artefacts contain layers of knowledge about historical cultures and relationships. The different agendas and experiences of librarians, archivists, and historians—all curators of historical records –have revealed or obscured encounter narratives concerning European and indigenous men and women.
Phenotypes of carriers of two mutated alleles in major cancer susceptibility genes
Authors: Laitman Yael , Niskakoski Anni , Bernstein-Molho Rinal , Koskinen Lotta , Rabina Daniel , Koskenvuo Juha , Friedman Eitan
Published: August 2024

Purpose

While cancer phenotypes in carriers of a single mutant allele in most major cancer susceptibility genes are well-established, there is a paucity of data on the phenotype of carriers of two pathogenic variants—double heterozygotes (DH) or homozygous carriers. Here, we describe the phenotype of carriers of homozygous and DH pathogenic sequence variants (PSVs) in major cancer susceptibility genes.

Methods

Individuals referred for multigene panel testing at Blueprint Genetics laboratory were included. Ethically approved comparison of cancer type and age at diagnosis between DH, homozygous, and single PSV carriers was performed per gene.

Results

Of 6,685 eligible participants, 928 (13.9%) were single heterozygous PSV carriers, 6 (0.09%) were homozygous PSV carriers, and 17 (0.25%) were DH PSV carriers. Mean age at diagnosis of any cancer among single PSV age was 46.8 ± 14.9 years and among DH PSV carriers 37.6 ± 13.0 years (P < 0.0001). Notably, age at diagnosis for breast cancer among single BRCA1 PSV carriers (n = 59) was 43.8 ± 8.7 years (p = 0.7606), among single BRCA2 PSV carriers (n = 52)—47.9 ± 13.0 years (p = 0.2274) compared with 42.3 ± 13.0 years among DH PSV carriers (n = 10- 9 of whom were carriers of either BRCA1 or BRCA2).

Conclusion

DH for PSV in two cancer susceptibility genes is a rare event, and the mean age at cancer diagnosis is younger in DH PSV carriers compared with single PSV carriers.
Effect of acute intravenous beta-blocker administration on myocardial blood flow during same-day hybrid CCTA/PET imaging
Authors: Gajic Marko , Galafton Andrei , Heiniger Pascal S. , Albertini Tobia , Jurisic Stjepan , Gebhard Catherine , Benz Dominik C. , Pazhenkottil Aju P. , Giannopoulos Andreas A. , Kaufmann Philipp A. , Buechel Ronny R.
Published: August 2024

This study aimed to evaluate the impact of acute intravenous beta-blocker administration on myocardial blood flow (MBF) during same-day hybrid coronary computed tomography angiography (CCTA) and 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). Previous research on the discontinuation of oral beta-blockers before MPI has shown mixed results, with no studies yet exploring the acute intravenous administration in the context of same-day hybrid imaging. This retrospective study included patients with suspected chronic coronary syndromes undergoing same-day hybrid CCTA/13N-ammonia PET MPI. Exclusion criteria comprised coronary artery stenosis ≥ 50% or regional perfusion abnormalities on PET, and baseline oral beta-blocker medication. Intravenous metoprolol (up to 30 mg) was administered as needed for heart rate control before CCTA. MBF measurements were obtained at rest (rMBF) and during stress (sMBF), and myocardial flow reserve (MFR) was calculated. After excluding 281 patients, 154 were eligible for propensity-score matching, resulting in 108 patients divided into two equal groups based on beta-blocker administration. The groups showed no significant differences in baseline characteristics. Among those who received beta-blockers, there was a significant decrease in sMBF (2.21 [IQR 1.72–2.78] versus 2.46 [2.08–2.99] ml∙min−1∙g−1, p = 0.027) and MFR (3.46 [2.70–4.05] versus 3.79 [3.22–4.46], p = 0.030), respectively, compared to those who did not receive beta-blockers. In contrast, rMBF remained unaffected (0.65 [0.54–0.78] versus 0.64 [0.55–0.76] ml∙min−1∙g−1, p = 0.931). Acute intravenous beta-blocker administration significantly impacts MBF, leading to a slight reduction in sMBF and MFR. In contrast, rMBF appears unaffected, suggesting that beta-blockers primarily affect the coronary capacity to respond to vasodilators.
Molecular and cellular mechanisms of chemoresistance in paediatric pre–B cell acute lymphoblastic leukaemia
Authors: Lill Caleb B. , Fitter Stephen , Zannettino Andrew C. W. , Vandyke Kate , Noll Jacqueline E.
Published: August 2024

Paediatric patients with relapsed B cell acute lymphoblastic leukaemia (B-ALL) have poor prognosis, as relapse-causing clones are often refractory to common chemotherapeutics. While the molecular mechanisms leading to chemoresistance are varied, significant evidence suggests interactions between B-ALL blasts and cells within the bone marrow microenvironment modulate chemotherapy sensitivity. Importantly, bone marrow mesenchymal stem cells (BM-MSCs) and BM adipocytes are known to support B-ALL cells through multiple distinct molecular mechanisms. This review discusses the contribution of integrin-mediated B-ALL/BM-MSC signalling and asparagine supplementation in B-ALL chemoresistance. In addition, the role of adipocytes in sequestering anthracyclines and generating a BM niche favourable for B-ALL survival is explored. Furthermore, this review discusses the role of BM-MSCs and adipocytes in promoting a quiescent and chemoresistant B-ALL phenotype. Novel treatments which target these mechanisms are discussed herein, and are needed to improve dismal outcomes in patients with relapsed/refractory disease.
Causal inference of server- and client-side code smells in web apps evolution
Authors: Rio Américo , Abreu Fernando Brito e , Mendes Diana
Published: August 2024

Context

Code smells (CS) are symptoms of poor design and implementation choices that may lead to increased defect incidence, decreased code comprehension, and longer times to release. Web applications and systems are seldom studied, probably due to the heterogeneity of platforms (server and client-side) and languages, and to study web code smells, we need to consider CS covering that diversity. Furthermore, the literature provides little evidence for the claim that CS are a symptom of poor design, leading to future problems in web apps.

Objective

To study the quantitative evolution and inner relationship of CS in web apps on the server- and client-sides, and their impact on maintainability and app time-to-release (TTR).

Method

We collected and analyzed 18 server-side, and 12 client-side code smells, aka web smells, from consecutive official releases of 12 PHP typical web apps, i.e., with server- and client-code in the same code base, summing 811 releases. Additionally, we collected metrics, maintenance issues, reported bugs, and release dates. We used several methodologies to devise causality relationships among the considered irregular time series, such as Granger-causality and Information Transfer Entropy(TE) with CS from previous one to four releases (lag 1 to 4).

Results

The CS typically evolve the same way inside their group and its possible to analyze them as groups. The CS group trends are: Server, slowly decreasing; Client-side embed, decreasing and JavaScript,increasing. Studying the relationship between CS groups we found that the "lack of code quality", measured with CS density proxies, propagates from client code to server code and JavaScript in half of the applications. We found causality relationships between CS and issues. We also found causality from CS groups to bugs in Lag 1, decreasing in the subsequent lags. The values are 15% (lag1), 10% (lag2), and then decrease. The group of client-side embed CS still impacts up to 3 releases before. In group analysis, server-side CS and JavaScript contribute more to bugs. There are causality relationships from individual CS to TTR on lag 1, decreasing on lag 2, and from all CS groups to TTR in lag1, decreasing in the other lags, except for client CS.

Conclusions

There is statistical inference between CS groups. There is also evidence of statistical inference from the CS to web applications’ issues, bugs, and TTR. Client and server-side CS contribute globally to the quality of web applications, this contribution is low, but significant. Depending on the outcome variable (issues, bugs, time-to-release), the contribution quantity from CS is between 10% and 20%.
A computational approach for phase-field model of quasi-brittle fracture under dynamic loading
Authors: Vodička Roman
Published: August 2024

A computational model is formulated for studying dynamic crack propagation in quasi-brittle materials exposed to time-dependent loading conditions. Under such conditions, inertial effects of structural components play an important role in modelling crack propagation problems. The computational model is proposed within the theory of regularised cracks which uses a damage-like internal variable. Here, fracture considers phase-field damage which gives rise to a material degradation in a narrow material strip defining the regularised crack. Based on the energy formulation using the Lagrangian of the system, the proposed computational approach introduces a staggered scheme adopted to solve the coupled system and providing it in a variational form within the time stepping procedure. The numerical data are obtained by quadratic programming algorithms implemented together with a finite element code.
Advances in Video Analytics
Authors: Şahin Muhittin
Published: August 2024

Learners interact with content, assessments, peers, and instructors in digital learning environments. Videos, which are popular due to internet technologies, capture learners’ attention, boost motivation, and enhance learning. Learning analytics broadly optimize educational environments by analyzing data, with video analytics focusing specifically on video interactions to enhance learning outcomes. Video-player interactions (e.g., play, pause) and video content interactions (e.g., true-false questions) provide insights into learner behaviors. Lack of interaction is a major reason for high dropout rates in video platforms and MOOCs. Video analytics can help address this issue by analyzing and improving engagement with video content. This special issue has a specific focus on video analytics and impact of this field to the learning experience. Four articles were included in this special issue. The findings reveal that I) the type, length, and purpose of the video are important for student engagement, ii) important tips on video-based learning design are presented, iii) when interacting with the video player, pause, play, rewind and fast forward are the most commonly used interaction types., iv) providing more information about video interaction processes with dashboards would provide much more insight, and v) dividing the videos into more than one section both creates the perception of better structuring of the process and the segmentation of the videos contributes more to learning.
Insights into Patient Experiences with Facilitated Subcutaneous Immunoglobulin Therapy in Primary Immune Deficiency: A Prospective Observational Cohort
Authors: Yalcin Gungoren Ezgi , Yorgun Altunbas Melek , Dikici Ummugulsum , Meric Zeynep , Eser Simsek Isil , Kiykim Ayca , Can Salim , Karabiber Esra , Yakici Nalan , Orhan Fazil , Cokugras Haluk , Aydogan Metin , Ozdemir Oner , Bilgic Eltan Sevgi , Baris Safa , Ozen Ahmet , Karakoc-Aydiner Elif
Published: August 2024

Background

Immunoglobulin G replacement therapy (IgRT), intravenous (IV) and subcutaneous (SC) routes, is pivotal in treatment of primary immunodeficiencies (PID). In recent years, facilitated subcutaneous immunoglobulin (fSCIG), a combination of rHuPH20 and 10% IgG has emerged as a delivery method to combine advantages of both IV and SC.

Method

In an observational prospective cohort, we investigated patient experience with fSCIG in PID patients from 5 PID centers for up to 12 months. We assessed the efficacy and safety of this treatment with patient/caregiver- and physician-reported indicators. Additionally, we analyzed patient treatment satisfaction (TSQM-9) and quality of life (QoL).

Results

We enrolled 29 patients (22 pediatric and 7 adults; 14 females and 15 males; (median: 15, min–max: 2–40.9 years) who initiated fSCIG as IgRT-naive (n = 1), switched from conventional rapid-push 10% SCIG (n = 6) or IVIG (n = 22). Among the participants, 19 (65%) exhibited antibody deficiencies, 8 (27%) combined immunodeficiencies, and 2 (7%) immune dysregulations. Remarkably, targeted trough immunoglobulin G levels were achieved under all previous IgRTs as well as fSCIG. No severe systemic adverse drug reactions were documented, despite prevalent local (%86.45) and mild systemic (%26.45) adverse reactions were noted with fSCIG. Due to mild systemic symptoms, 2 patients switched from fSCIG to 10% SCIG. The patient satisfaction survey revealed a notable increase at 2-4th (p = 0.102); 5-8th (p = 0.006) and 9-12th (p < 0.001) months compared to the baseline. No significant trends were observed in QoL surveys.

Conclusion

fSCIG demonstrates admissable tolerability and efficacy in managing PIDs in addition to notable increase of patients’ drug satisfaction with IgRT. The identified benefits support the continuation of this therapy despite the local reactions.
A Novel Case of IFNAR1 Deficiency Identified a Common Canonical Splice Site Variant in DOCK8 in Western Polynesia: The Importance of Validating Variants of Unknown Significance in Under-Represented Ancestries
Authors: Huynh Aimee , Gray Paul E , Sullivan Anna , Mackie Joseph , Guerin Antoine , Rao Geetha , Pathmanandavel Karrnan , Mina Erika Della , Hollway Georgina , Hobbs Matthew , Enthoven Karen , O’Young Patrick , McManus Sam , Wainwright Luke H. , Higgins Megan , Noon Fallon , Wong Melanie , Bastard Paul , Zhang Qian , Casanova Jean-Laurent , Hsiao Kuang-Chih , Pinzon-Charry Alberto , Ma Cindy S , Tangye Stuart G.
Published: August 2024

Advanced genomic technologies such as whole exome or whole genome sequencing have improved diagnoses and disease outcomes for individuals with genetic diseases. Yet, variants of unknown significance (VUS) require rigorous validation to establish disease causality or modification, or to exclude them from further analysis. Here, we describe a young individual of Polynesian ancestry who in the first 13 mo of life presented with SARS-CoV-2 pneumonia, severe enterovirus meningitis and adenovirus gastroenteritis, and severe adverse reaction to MMR vaccination. Genomic analysis identified a previously reported pathogenic homozygous variant in IFNAR1 (c.1156G > T, p.Glu386* LOF), which is common in Western Polynesia. Moreover, a new and putatively deleterious canonical splice site variant in DOCK8 was also found in homozygosity (c.3234 + 2T > C). This DOCK8 variant is common in Polynesians and other under-represented ancestries in large genomic databases. Despite in silico bioinformatic predictions, extensive in vitro and ex vivo analysis revealed the DOCK8 variant likely be neutral. Thus, our study reports a novel case of IFNAR1 deficiency, but also highlights the importance of functional validation of VUS, including those predicted to be deleterious, and the pressing need to expand our knowledge of the genomic architecture and landscape of under-represented populations and ancestries.
Establishing a Cutoff Score for the Healing after Gender-based Violence Scale (GBV-Heal): A Brief Report
Authors: Sinko Laura , Kita Sachiko , Arnault Denise Saint
Published: August 2024

Purpose

To evaluate a cutoff score for the Healing after Gender-based Violence Scale (GBV-Heal)—an instrument to assess recovery progress for survivors of GBV.

Methods

We surveyed 321 women-identifying GBV survivors living in the Midwestern United States from April to December 2022 to evaluate their mental health symptom burden, trauma coping self-efficacy, sense of meaning, healing progress, and recovery stage. We used Receiver Operating Characteristic (ROC) analysis to determine the best cutoff score for the GBV-Heal.

Results

We found a cutoff point of 64 for the GBV-Heal. Those above this cutoff point were found to have significantly lower PTSD and depression symptoms and significantly higher trauma coping self-efficacy and sense of meaning compared to those below the cutoff point.

Conclusions

The GBV-Heal cutoff score can help practitioners recognize survivors needing additional support or resources as they navigate their healing journey. The use of this scale can promote tailored care for survivors seeking healing support in a variety of public health sectors.
Early warning signals of complex critical transitions in deterministic dynamics
Authors: Evers Kyra , Borsboom Denny , Fried Eiko I. , Hasselman Fred , Waldorp Lourens
Published: August 2024

Early Warning Signals (EWS) have generated much excitement for their potential to anticipate transitions in various systems, ranging from climate change in ecology to disease staging in medicine. EWS hold particular promise for bifurcations, a transition mechanism in which a smooth, gradual change in a control parameter of the system results in a rapid change in system dynamics. The predominant reason to expect EWS is because many bifurcations are preceded by Critical Slowing Down (CSD): if assuming the system is subject to continuous, small, Gaussian noise, the system is slower to recover from perturbations closer to the transition. However, this focus on warning signs generated by stochasticity has overshadowed warning signs which may already be found in deterministic dynamics. This is especially true for higher-dimensional systems, where more complex attractors with intrinsic dynamics such as oscillations not only become possible—they are increasingly more likely. The present study focuses on univariate and multivariate EWS in deterministic dynamics to anticipate complex critical transitions, including the period-doubling cascade to chaos, chaos-chaos transitions, and the extinction of a chaotic attractor. In a four-dimensional continuous-time Lotka–Volterra model, EWS perform well for most bifurcations, even with lower data quality. The present study highlights three reasons why EWS may still work in the absence of CSD: changing attractor morphology (size, shape, and location in phase space), shifting power spectra (amplitude and frequency), and chaotic transitional characteristics (density across attractor). More complex attractors call for different warning detection methods to utilise warning signs already contained within purely deterministic dynamics.
Exploring chaos and ergodic behavior of an inductorless circuit driven by stochastic parameters
Authors: Seth Soumyajit , Bera Abhijit , Pakrashi Vikram
Published: August 2024

There exist extensive studies on periodic and random perturbations of various smooth maps investigating their dynamics. Unlike smooth maps, non-smooth maps are yet to be studied extensively under a stochastic regime. This paper presents a stochastic piecewise-smooth map derived from a simple inductorless switching circuit. The stochasticity is introduced in parameter values. The distribution of the parameter values is bounded and randomly selected from uniform and triangular distributions and ranges between high and low bifurcation parameter values of the deterministic map. Due to this inherent stochasticity in parameter values, the time evolution of the state variable cannot be predicted at a specific time instant. We observe that the state variable exhibits completely ergodic behavior when the minimum value of the parameter is the same as the minimum bifurcation parameter of the deterministic system. However, the ensemble average of the state variable converges to a fixed value. The system demonstrates nonchaotic behavior for a particular range of parameter values but the deterministic map in that bifurcation range shows interplay between chaos and periodic orbits. The values of Lyapunov exponents decrease monotonically with increased asymmetry of the distribution from which the bifurcation parameter values are chosen. We determine the probability density function of the stochastic map and verify its invariance under initial conditions. The most noteworthy result is the disappearance of chaotic behavior when the lower range of the distribution is varied while maintaining a fixed upper threshold for a particular distribution, even though the deterministic map exhibits an array of periodic and chaotic behaviors within the range. As the period-incrementing cascade with chaotic inclusion only occurs in nonsmooth maps, this paper numerically shows the stochasticity of a piecewise-smooth map obtained from a practical system for the first time where randomness is introduced in the parameter space.
Spelling morphology in Hebrew: Comparing monolingual and bilingual children
Authors: Michaly Tamar , Prior Anat
Published: August 2024

Bilingual children are at risk for gaps in literacy in the societal language compared to monolingual peers. However, most research has focused on reading achievement, and only few studies have investigated spelling abilities, with contradictory findings. Here, we compare Hebrew spelling skill and its predictors in bilingual and monolingual elementary school children, immersed in Hebrew as a societal language. Specifically, we examined the morphological elements in Hebrew spelling. Monolingual children outperformed bilingual children in spelling accuracy, in both 2nd and 4th grade. In addition, phonological awareness and morphological awareness were significant predictors of spelling for both groups, but their relative contribution differed across the groups. Finally, even though bilingual children had lower morphological knowledge than monolingual peers, both groups showed the expected developmental pattern of spelling function letters more accurately than root letters. This pattern in Hebrew spelling acquisition is driven by the morpho-orthographic regularities of the language. These results support previous findings emphasizing the role of morphology in Hebrew spelling acquisition, extending them to bilingual children. We suggest that examining the linguistic backgrounds of children and the unique characteristics of the language and orthography are crucial for reaching a nuanced understanding of bilingual spelling acquisition.
Category theory in consciousness science: going beyond the correlational project
Authors: Prentner Robert
Published: August 2024

We discuss the potential of applying category theory to the study of consciousness. We first review a recent proposal from the neurosciences of consciousness to illustrate the “correlational project”, using the integrated information theory of consciousness as an example. We then discuss some technical preliminaries related to categories and in particular to the notion of a functor, which carries the bulk of conceptual weight in many current discussions. We then look at possible payoffs of this project—getting to grips with the hard problem, theory integration, and exploiting explanatory dualities—and discuss possible avenues for further research, stressing the need to better develop the categorical representation of consciousness, in particular its phenomenological structure. A better understanding of consciousness cannot be achieved by merely studying the physical brain. By contrast, the categorical treatment even suggests application beyond the domain of neuroscience, for example in computer science and artificial intelligence research, while also emphasizing the primacy of (phenomenal) experience.
Role of metal nanoparticles in organogenesis, secondary metabolite production and genetic transformation of plants under in vitro condition: a comprehensive review
Authors: Prasad Aparna , Sidhic Jameema , Sarbadhikary Paromita , Narayanankutty Arunaksharan , George Satheesh , George Blassan P. , Abrahamse Heidi
Published: August 2024

Nanomaterials usually have specific characteristics due to their incredibly tiny size, which also increases their surface area, providing a more interactive surface. Compared to their macro-sized counterparts, these tiny nanoparticles exhibit a multitude of size-dependent properties. Plant tissue culture (PTC) plays an important role in bioactive chemical synthesis, mass cultivation, protection, genetic control, and plant enhancement. Different nanoparticles (NPs) are utilized to improve the tissue culture responses of explants. Various nanoparticles, including cobalt, copper, silver, gold, zinc, selenium, titanium, iron, palladium, cerium, indium, manganese, aluminum, barium, silicon, nickel, zirconium, and their oxides, are used in this regard. Nowadays, it is critical to use nanosystems in conjunction with PTC for mass reproduction, conservation, genetic engineering, crop enhancement, and the synthesis of bioactive compounds. Nanostructured metal oxides play an important role in in vitro plant cultivation. The use of metal nanoparticles (MNPs) has successfully removed microbial contaminants from explants and had a favorable impact on organogenesis (increasing the growth of shoots, roots, and multiplication ratios), callus induction, metabolic changes, and the synthesis of secondary metabolites (NPs are used as elicitors or stress agents). Additionally, NPs cause somaclonal variation (modifications to DNA), improve cryopreservation (increasing the survival rate), and enhance genetic transformation (facilitating gene transformation to bypass the plant cell wall barrier and accelerating protoplast isolation). This review aims to summarize the current breakthroughs achieved by integrating nanotechnology with PTC.

Graphical abstract
Comparative Study on Removal of Acid Violet 90 dye by using Catalytic Ozonation Processes with n.CeO2, n.ZnO and n.CeO2/n.ZnO Nanocatalysts and Kinetic Examination
Authors: Erden Büşra , Katırcıoğlu Sınmaz Gamze , Aksu Meryem , Tanattı N. Pınar , Has Muhammed
Published: August 2024

The textile industry uses high amounts of water and dyestuffs, and accordingly, wastewater containing significant amounts of dyestuffs is produced, which have to be treated before being discharged to the environment. The aim of this study is the treatment of synthetic wastewater containing 50 mg/L Acid Violet 90 dyestuff with catalytic ozonation process have been investigated by using n.CeO2, n.ZnO and n.CeO2/n.ZnO (1:1, m:m) nanocatalysts. The process optimization has been performed with the pH, ozone dose, catalyst dose and reaction time parameters. While the optimum conditions have been determined as pH 3, 600 mg/L ozone dose, 10 min reaction time, for all three catalysts, catalyst doses have differed as 50 mg/L for n. CeO2, 30 mg/L for n.ZnO and n.CeO2/n.ZnO. The removal efficiencies of AV 90 have been achieved as 97.04, 96.2 and 95.7% for n.CeO2, n.ZnO and n.CeO2/n.ZnO catalysts, respectively. Kinetic analyses showed that color removal of AV 90 dyestuff followed First order kinetics with R2 values of 0.9987 (n.CeO2), 0.9912 (n.ZnO) and 0.9923 (n.CeO2/n.ZnO) and reaction rate constant values have been calculated as 0,3435 (n.CeO2), 0,3551(n.ZnO) and 0,3226 (n.CeO2/n.ZnO) min−1.
Genomic diversity, antibiotic resistance, and virulence in South African Enterococcus faecalis and Enterococcus lactis isolates
Authors: Olanrewaju Oluwaseyi Samuel , Molale-Tom Lesego G. , Bezuidenhout Cornelius C.
Published: August 2024

This study presents the empirical findings of an in-depth genomic analysis of Enterococcus faecalis and Enterococcus lactis isolates from South Africa. It offers valuable insights into their genetic characteristics and their significant implications for public health. The study uncovers nuanced variations in the gene content of these isolates, despite their similar GC contents, providing a comprehensive view of the evolutionary diversity within the species. Genomic islands are identified, particularly in E. faecalis, emphasizing its propensity for horizontal gene transfer and genetic diversity, especially in terms of antibiotic resistance genes. Pangenome analysis reveals the existence of a core genome, accounting for a modest proportion of the total genes, with 2157 core genes, 1164 shell genes, and 4638 cloud genes out of 7959 genes in 52 South African E. faecalis genomes (2 from this study, 49 south Africa genomes downloaded from NCBI, and E. faecalis reference genome). Detecting large-scale genomic rearrangements, including chromosomal inversions, underscores the dynamic nature of bacterial genomes and their role in generating genetic diversity. The study uncovers an array of antibiotic resistance genes, with trimethoprim, tetracycline, glycopeptide, and multidrug resistance genes prevalent, raising concerns about the effectiveness of antibiotic treatment. Virulence gene profiling unveils a diverse repertoire of factors contributing to pathogenicity, encompassing adhesion, biofilm formation, stress resistance, and tissue damage. These empirical findings provide indispensable insights into these bacteria’s genomic dynamics, antibiotic resistance mechanisms, and virulence potential, underlining the pressing need to address antibiotic resistance and implement robust control measures.
COVID-19 pandemic-related drugs and microplastics from mask fibers jointly affect soil functions and processes
Authors: dela Cruz Jeane , Lammel Daniel , Kim Shin Woong , Bi Mohan , Rillig Matthias
Published: August 2024

The COVID-19 pandemic has led to an unprecedented increase in pharmaceutical drug consumption and plastic waste disposal from personal protective equipment. Most drugs consumed during the COVID-19 pandemic were used to treat other human and animal diseases. Hence, their nearly ubiquitous presence in the soil and the sharp increase in the last 3 years led us to investigate their potential impact on the environment. Similarly, the compulsory use of face masks has led to an enormous amount of plastic waste. Our study aims to investigate the combined effects of COVID-19 drugs and microplastics from FFP2 face masks on important soil processes using soil microcosm experiments. We used three null models (additive, multiplicative, and dominative models) to indicate potential interactions among different pharmaceutical drugs and mask MP. We found that the multiple-factor treatments tend to affect soil respiration and FDA hydrolysis more strongly than the individual treatments. We also found that mask microplastics when combined with pharmaceuticals caused greater negative effects on soil. Additionally, null model predictions show that combinations of high concentrations of pharmaceuticals and mask MP have antagonistic interactions on soil enzyme activities, while the joint effects of low concentrations of pharmaceuticals (with or without MP) on soil enzyme activities are mostly explained by null model predictions. Our study underscores the need for more attention on the environmental side effects of pharmaceutical contamination and their potential interactions with other anthropogenic global change factors.
An Enquiry into MNEs’ CSR Practices: Literature Assessment, Managerial Implications, and Academic Perspectives
Authors: Leonidou Leonidas C. , Marinova Svetla T. , Marinov Marin A. , Eduardsen Jonas S. , Eteokleous Pantelitsa P.
Published: August 2024

As a result of growing concerns by stakeholder groups in different parts of the world for the economic, social, and environmental value created by multinational enterprises (MNEs), research has explored MNEs’ corporate social responsibility (CSR). This article extends existing knowledge by steering through extant research on MNE’s CSR activities embedded in MNEs’ international competitive behavior. The paper reviews 208 empirical studies conducted on this subject during the period 1997–2022 and offers a systematized analysis along aspects pertaining to theoretical perspectives, research design, scope, method, and thematic emphasis. It synthesizes existing knowledge in an integrative conceptual framework incorporating the key thematic priorities and the relations between them. It also provides an evaluation of the key managerial implications extracted from these studies by 114 managers of MNEs having their headquarters in the U.S.A., Germany, and China. Finally, it offers fruitful directions for future research based on the findings of a survey among 42 international business scholars with expertise in this field.
Glucometrics utilisation in an urban teaching hospital in ireland: current practice and future aims
Authors: McGauran Joseph , Dart Arianna , Reilly Phyllis , Widdowson Matthew , Boran Gerard
Published: August 2024

Background

Dysglycaemia in hospitalised patients is associated with poorer clinical outcomes, including cardiovascular events, longer hospital stays, and increased risk of mortality. Therefore, glucose monitoring is necessary to achieve best outcomes.

Aims

This audit assesses use of point-of-care (POC) blood glucose (BG) testing in Tallaght University Hospital (TUH) over an 8-day period. It evaluates compliance with international and TUH glucose monitoring protocols and determines frequency of diabetes team consultations for inpatient adults.

Methods

Data from an 8-day period (12/03/2023–19/03/2023) were extracted from the TUH COBAS-IT system and analysed. Invalid tests were excluded. Hyperglycaemia was defined as ≥ 10 mmol/L and hypoglycaemia as ≤ 3.9 mmol/L. Persistent hyperglycaemia was defined as two BG results of ≥ 10 mmol/L. A chart review was conducted on adult patients with persistent hyperglycaemia to assess for HbA1C results, diabetes diagnosis, and diabetes consult.

Results

3,530 valid tests were included and analysed. 674 individual patients had tests done. 1,165 tests (33.00%) were hyperglycaemic and 75 (2.12%) were hypoglycaemic. 68.25% of adults with persistent hyperglycaemia had an HbA1C test performed or documented within three months. 42.71% of inpatient adults with persistent hyperglycaemia and a known diabetes diagnosis received a consult from the diabetes team.

Conclusion

Increased adherence to hospital protocols for testing HbA1C in adults with persistent hyperglycaemia could improve treatment and clinical outcomes. Increased diabetes team consultation could facilitate appropriate treatment and improve patient outcomes in persistently hyperglycaemic adult patient populations.
The role of emotions in collective responses to in-group norm violations: the case of university’s sensitivity to the natural environment norm
Authors: Sarı Erkin , Yücel Emine , Bükün Mehmet Fatih
Published: August 2024

The primary objective of this study was to examine the influence of perceptions of environmental in-group norm violations and the associated emotions on the level of support for environmental social movements. Particularly, we examined the association between collective action intentions and the emotions of anger, disgust, guilt, and pride elicited in response to the violation of in-group pro-environmental norms. There were 221 undergraduate participants (154 females, 62 males, 5 non-binary) studying at a Turkish state university, where preserving on-campus environment is perceived as the norm. Participants were randomly assigned to one of two experimental conditions in which on-campus environmental norms were violated or adopted by their peers (i.e., in-group members). Then, their perceptions of norm-violation, emotions about their peers’ on-campus environmental behaviors, and collective action intentions in improving campus’s environmental circumstances were measured. We used structural equation modeling to test the hypothesized links between the study variables. Our findings revealed that participants exhibited high levels of norm violation anger, guilt, and disgust and low levels of pride when their peers were presented as polluters. Only anger and pride were found to be influential in motivating intentions for collective actions. Norm violation perception by itself was not instrumental in mobilizing individuals for the sake of the environment. When coupled with feelings of anger and pride, its association with endorsing intentions for environmental collective action became significant. The current findings shed light on the emotions associated with norm violation and their potential to foster pro-environmental collective action.
Impact of Cold Atmospheric Plasma Pretreatment on the Recovery of Phenolic Antioxidants from Spent Coffee Grounds
Authors: Kyriakoudi Anastasia , Loukri Anastasia , Christaki Stamatia , Oliinychenko Yelyzaveta , Stratakos Alexandros Ch. , Mourtzinos Ioannis
Published: August 2024

In the present study, cold atmospheric plasma (CAP) was employed as a pretreatment method for the extraction of phenolic compounds from spent coffee grounds (SCGs). The impact of CAP treatment conditions, i.e., thickness of the SCGs layer (mm), distance between the plasma source and the SCGs layer (mm) and duration of CAP treatment (min), on the total phenol content, in vitro antioxidant activity, as well as caffeine and chlorogenic acid content of SCGs, was investigated. The process parameters were optimized with the aid of response surface methodology (RSM). After optimizing the CAP pretreatment conditions, the CAP-treated SCGs were subjected to ultrasound-assisted extraction using ethanol as the extraction solvent. The optimum conditions for CAP treatment identified, i.e., thickness, 1 mm; distance, 16 mm; and duration, 15 min, led to a significant enhancement in the recovery of bioactive compounds from SCGs compared to those obtained from untreated SCGs. Total phenolic content and antioxidant activity significantly increased (i.e., TPC from 19.0 ± 0.7 to 24.9 ± 1.4 mg GAE/100 g dry SCGs, ADPPH from 106.7 ± 5.01 to 112.3 ± 4.3 μmol Trolox/100 g dry SCGs, AABTS from 106.7 ± 5.01 to 197.6 ± 5.8 μmol Trolox/100 g dry SCGs, ACUPRAC from 17938 ± 157 to 18299 ± 615 μmol Trolox/100 g dry SCGs). A significant increase in caffeine content from 799.1 ± 65.1 mg to 1064 ± 25 mg/100 g dry SCGs and chlorogenic acid content from 79.7 ± 15.3 mg to 111.3 ± 3.3 mg/100 g dry SCGs, was also observed. Overall, CAP pre-treatment can be used to enhance the recovery of bioactive compounds from SCGs.
Differential Age-Based Response Induced by a Commercial Probiotic Supplementation in Pastured Goats
Authors: Ndegwa Eunice , Elhadedy Doaa E. , Richey Caitlyn , Kim Chyer , Yousuf Adnan B.
Published: August 2024

The potential benefit of probiotics in small ruminant production systems has largely been unexplored. We evaluated the effect of a goat commercial probiotic on health and performance indicators in pastured goats from birth until 10 months. We randomly allocated 26 newborn nursing goat kids to two groups: a control group that received saline and a treatment group that received a commercial probiotic paste orally. We evaluated select observable health indicators (inappetence, diarrhea, coughing), weight, immunity (IgA, IgG, and innate immune response), total protein, hematocrit (HCT), total lactic acid bacteria (LAB), total coliforms, and prevalence of Escherichia coli (E. coli) primary virulence genes (stx1, stx2, and eae) during the experimental period. The results revealed no significant differences in the health indicators, LAB count, and total E. coli count. Prevalence of stx1 at 1 week of age and both stx1 and stx2 genes 4 months post-weaning was significantly (P < 0.05) higher in probiotic-supplemented goats. Probiotic supplementation significantly (P < 0.05) increased the total protein and IgA 1 month post-supplementation during the pre-weaning period and innate immune markers 2 days post-weaning. The HCT in probiotic-supplemented goats was significantly (P < 0.05) higher at 1 and 2 months post-weaning. The growth rate was not affected by probiotic supplementation in pre- and peri-weaned goats but was significantly (P < 0.05) lowered in goats older than 4 months in the supplemented group. In this pastured goat production study, there were mixed responses to a commercial probiotic in healthy goats based on age. The study suggests that early daily probiotic supplementation in pre-weaned pastured goats may have immune stimulation benefits, but in older healthy animals, post-weaning net benefits are unclear and further research is recommended.
Unsteady nonlinear lifting line model for active gust load alleviation of airplanes
Authors: Beyer Yannic , Ullah Junaid , Steen Meiko , Hecker Peter
Published: August 2024

Active gust load alleviation is an important technology for designing future passenger airplanes to be lighter and thus more environmentally friendly. Unsteady Reynolds-averaged Navier–Stokes (URANS) simulations are typically used to accurately calculate gust loads, but because of their high computational cost, they can only be performed at a few selected operating points. In simpler potential theory models, stall is neglected, resulting in loss of accuracy. In this paper, a low-order unsteady aerodynamics wing model is presented, which is able to represent well compressible flow with stall. Furthermore, the model offers the possibility to modularly incorporate actuators, which allows the design and evaluation of active load alleviation systems. The model is based on a conventional unsteady 2D airfoil model including a dynamic stall model. The dynamic stall model requires viscous steady coefficients, e.g. from 2D steady RANS computations. This 2D airfoil model is coupled with a 3D steady-state lifting line model. The model is applied to the LEISA research airplane and extensively validated with URANS results. It performs well in calculating gust loads with and without simultaneous flap deflections, and provides significantly more accurate results in the case of stall than when stall is neglected.
Topographic variation and fluid flow characteristics in rough contact interface
Authors: Ji Jiawei , Sun Wei , Du Yu , Zhu Yongqing , Guo Yuhang , Liu Xiaojun , Jiao Yunlong , Liu Kun
Published: August 2024

Understanding flow characteristics of fluid near rough contact is important for the design of fluid-based lubrication and basic of tribology physics. In this study, the spreading and seepage processes of anhydrous ethanol in the interface between glass and rough PDMS are observed by a homemade optical in-situ tester. Digital image processing technology and numerical simulation software are adapted to identify and extract the topological properties of interface and thin fluid flow characteristics. Particular attention is paid to the dynamic evolution of the contact interface morphology under different stresses, the distribution of microchannels in the interface, the spreading characteristics of the fluid in contact interface, as well as the mechanical driving mechanism. Original surface morphology and the contact stress have a significant impact on the interface topography and the distribution of interfacial microchannels, which shows that the feature lengths of the microchannels, the spreading area and the spreading rate of the fluid are inversely proportional to the load. And the flow path of the fluid in the interface is mainly divided into three stages: along the wall of the island, generating liquid bridges, and moving from the tip side to the root side in the wedge-shaped channel. The main mechanical mechanism of liquid flow in the interface is the equilibrium between the capillary force that drives the liquid spreading and viscous resistance of solid wall to liquid. In addition, the phenomenon of “trapped air” occurs during the flow process due to the irregular characteristics of the microchannel. This study lays a certain theoretical foundation for the research of microscopic flow behavior of the liquid in the rough contact interface, the friction and lubrication of the mechanical system, and the sealing mechanism.
Hybrid platforms with free entry: demand-enhancing activities
Authors: Bonazzi Leda Maria , Martina Riccardo , Ursino Giovanni
Published: August 2024

We study the decision of a platform as to the quantity and quality of the products to sell directly on its own marketplace, where also third-party sellers decide how much to invest in the quality of their products. Using a representative agent framework that is based on a quasi-linear quality-augmented indirect utility function, we show that, under free entry, the quality investments of sellers do not change with platform entry, while the number of joining sellers does. Moreover, contrarily to what is found in the received literature, the platform may go hybrid even in the case it does not enjoy a competitive advantage vis-á-vis third-party sellers. We then study the welfare implications of a platform’s entry decision and show that promoting sellers’ investments and/or contrasting platform entry may lead to a larger as well as a lower consumer welfare. This depends on the platform’s response in equilibrium, both in terms of changes of its quality-enhancing investments and the fee charged on the revenues of third-party sellers.