bluuebunny/crossref_metadata_2025 huggingface dataset:
Cause of Death in Follicular Lymphoma in the First Decade of the Rituximab Era: A Pooled Analysis of French and US Cohorts
Authors: Sarkozy Clémentine , Maurer Matthew J. , Link Brian K. , Ghesquieres Hervé , Nicolas Emmanuelle , Thompson Carrie A. , Traverse-Glehen Alexandra , Feldman Andrew L. , Allmer Cristine , Slager Susan L. , Ansell Stephen M. , Habermann Thomas M. , Bachy Emmanuel , Cerhan James R. , Salles Gilles
Published: November 2018

Purpose

Although the life expectancy of patients with follicular lymphoma (FL) has increased, little is known of their causes of death (CODs) in the rituximab era.

Patients and Methods

We pooled two cohorts of newly diagnosed patients with FL grade 1-3A. Patients were enrolled between 2001 and 2013 in two French referral institutions (N = 734; median follow-up 89 months) and 2002 and 2012 in the University of Iowa and Mayo Clinic Specialized Program of Research Excellence (SPORE; N = 920; median follow-up 84 months). COD was classified as being a result of lymphoma, other malignancy, treatment related, or all other causes.

Results

Ten-year overall survival was comparable in the French (80%) and US (77%) cohorts. We were able to classify COD in 248 (88%) of 283 decedents. In the overall cohort, lymphoma was the most common COD, with a cumulative incidence of 10.3% at 10 years, followed by treatment-related mortality (3.0%), other malignancy (2.9%), other causes (2.2%), and unknown (3.0%). The 10-year cumulative incidence of death as a result of lymphoma or treatment was higher than death as a result of all other causes for each age group (including patients ≥ 70 years of age at diagnosis [25.4% v 16.6%]) Follicular Lymphoma International Prognostic Index score 3 to 5 (27.4% v 5.2%), but not Follicular Lymphoma International Prognostic Index score 0 to 1 (4.0% v 3.7%); for patients who failed to achieve event-free survival within 24 months from diagnosis (36.1% v 7.0%), but not for patients who achieved event-free survival within 24 months of diagnosis (6.7% v 5.7%); and for patients with a history of transformed FL (45.9% v 4.7%), but not among patients without (8.1% v 6.2%). Overall, 77 of 140 deaths as a result of lymphoma occurred in patients whose FL transformed after diagnosis.

Conclusion

Despite the improvement in overall survival in patients with FL in the rituximab era, their leading COD remains lymphoma, especially after disease transformation. Treatment-related mortality also represents a concern, which supports the need for less-toxic therapies.
МОДЕЛЬ СИСТЕМЫ УПРАВЛЕНИЯ РАБОТОЙ С ОДАРЕННЫМИ ДЕТЬМИ В РЕГИОНЕ
Authors: Parfenova Galina Leonidovna , Kolesova Svetlana Vladislavovna
Published: November 2018

Предмет работы: моделирование и управление пролонгированным сопровождением и развитием детской одаренности в образовательном процессе.Цель работы: обоснование и создание модели системы управления работой с одаренными детьми в регионе, которая позволит ее реальным и потенциальным участникам осуществлять продуктивное взаимодействие, комплексное психолого-педагогическое, научное сопровождение одаренных детей в образовательном пространстве, создавать условия для успешной самореализации одаренных личностей различного возраста.Методологическая основа работы: системный, культурологический, субъектный и личностно-ориентированный подходы.Метод работы: моделирование – построение структурно-функциональной и описательной моделей.Результаты: обоснована актуальность разработки и внедрения в национальное образовательное пространство модели системы управления работой с одаренными детьми в регионе; показана структура, направления и содержание деятельности университетского Центра развития одаренности, его взаимодействие с другими структурными подразделениями университета, координация работы Центра с образовательными, культурными, спортивными учреждениями и учреждениями дополнительного образования в регионе.Область применения результатов: обучение, воспитание, развитие, профессиональная ориентация одаренных детей, психолого-педагогическое сопровождение одаренных детей в образовании.Выводы: представленная система управления работой с одаренными детьми направлена не только на развитие одаренности ребенка, но и на становление его личности, сохранение и укрепление его здоровья, а также повышение психологической и педагогической культуры окружающих взрослых. Модель может быть адаптирована к особенностям конкретного региона России.
ПРЕДСТАВЛЕНИЯ ОБ ИДЕАЛЬНОЙ ЖЕНЩИНЕ У МУЖЧИН С РАЗНОЙ САМООЦЕНКОЙ
Authors: Zarubko Elena Yurievna
Published: November 2018

Цель статьи – изучить особенности представлений об идеальной женщине у мужчин с разной самооценкой.Метод и методология исследования. В исследовании участвовали 102 респондента мужского пола. Выборку составили три возрастные группы: 18–24 года, 26–32 года, 33–40 лет. В каждой возрастной группе 34 респондента. Самооценка измерялась методикой изучения самооценки Т. Дембо–С. Рубинштейн в модификации П.В. Яньшина, в результате респонденты были разделены на четыре группы по уровню самооценки: завышенная (n=30 человек), высокая (n=30), средняя (n=30), низкая(n=12). Представления об идеальной женщине измерялись семантическим дифференциалом. Данные обрабатывались методами факторного и кластерного анализа.Результаты. Выявлено значительное сходство в представлениях мужчин с разной самооценкой о том, какой должна быть идеальная женщина (заботливая, понимающая, честная, преданная, стройная и фигуристая). В целом мужчины видят в качестве идеала женщину, соответствующую традиционному женскому образу. Традиционный образ женщины имеет позитивную коннотацию и противопоставляется современному образу. Важную роль в образе идеальной женщины играет внешняя привлекательность. Выявлены особенности представлений об идеальной женщине, специфичные для мужчин с разной самооценкой. У мужчин с низкой самооценкой в образе идеальной женщины преобладают традиционно женские характеристики (понимающая, не вульгарная, чистоплотная, хозяйственная), у мужчин с завышенной самооценкой в образе идеальной женщины преобладают характеристики «эмансипированной» женщины (целеустремленная, самостоятельная, с характером).Область применения результатов. Результаты могут использоваться в консультативной практике для оптимизации отношений в паре, например, для работы с ожиданиями к партнёру; для помощи в решении личностных проблем, связанных с гендерной идентичностью.
ЛИЧНОСТНЫЕ И НЕИЗМЕНЯЕМЫЕ КАТЕГОРИИ ИДЕНТИЧНОСТИ ВОСПИТАТЕЛЕЙ В ЗАВИСИМОСТИ ОТ ОБРАЗОВАНИЯ И КОНФЕССИИ
Authors: Kolinichenko Irina Aleksandrobna , Voronkina Lubov Borisovna
Published: November 2018

Цель. В статье анализируются результаты исследования различий между личностными и неизменяемыми категориями идентичности у воспитателей дошкольных учреждений в двух независимых группах, отличающихся по степени получения образования (незаконченное высшее и законченное высшее) и конфессиональной принадлежности (христианство и мусульманство).Методы исследования. Исследование различий между категориями идентичности испытуемых проводилось при помощи включенного наблюдения и методики М. Куна-Маркпатленда (в модификации). Статистический анализ различий – с помощью непараметрического U-критерия Манна-Уитни пакета Statistica for Windows 8.Результаты. Выявлены межгрупповые различия при оценке характеристик идентичности в зависимости от образования и конфессии. На высоком уровне значимости категория личностной идентичности выше у воспитателей, получивших высшее образование 5–7 лет назад, чем у испытуемых, получающих его в период исследования. Межгрупповые различия при оценке идентичности в зависимости от принадлежности к конфессии, желательность неизменяемых категорий статистически более выражены в группе воспитателей, обозначивших себя как христиан в отличие от воспитателей, приписывающих себе мусульманскую конфессию.Область применения результатов. Результаты исследования могут быть применены в сфере психологического сопровождения развития личности воспитателей дошкольных учреждений и прогнозирования профессионального развития больших социальных групп воспитателей.
ОШИБОЧНОСТЬ И СУБЪЕКТИВНОСТЬ ИСПОЛЬЗОВАНИЯ ТЕРМИНА «ГОМОФОБИЯ» В НАУЧНОМ И ОБЩЕСТВЕННОМ ДИСКУРСЕ
Authors: Lysov Viсtor Grigorievitsch
Published: November 2018

Цель. Среди значительной части общества наблюдается критическое отношение к однополой сексуальной активности, степень выражения которого варьирует от поддержки юридического противодействия попыткам изменить институт брака с целью включить в него однополые партнёрства до единичных случаев насилия в отношении представителей гомосексуального сообщества. Подобное критическое отношение, в независимости от степени его проявления и причин, иногда обозначается как т.н. «гомофобия». С другой стороны, употребление подобного термина вызывает вопросы по поводу адекватности, точности и непредвзятости. Целью данного исследования является анализ (а) происхождения термина «гомофобия»; (б) адекватности его прикладного использования; (в) политических мотивов применения; (г) концепций, описывающих биологические причины критического отношения к однополой активности.Метод и методология работы. Основу исследования образуют феноменологический, описательный (дескриптивный) и сравнительный (компаративистский) методы, а также принцип систематизации и обобщения данных теоретических и практических исследований.Результаты. Термин «гомофобия» возник в начале 1970-х гг. в среде гомосексуального движения Соединённых Штатов. Прикладное использование термина «гомофобия» является необъективным по нескольким фундаментальным причинам. Употребление термина «гомофобия» в общественной риторике носит предвзятый, политический характер. Существуют различные модели, объясняющие причины критического восприятия однополого поведения, интерес представляет собой модель поведенческой иммунной системы. Использование термина «гомофобия» в научной деятельности для обозначения всего спектра критического отношения к однополой активности не имеет научного обоснования и является некорректным. Кроме того, использование термина «гомофобия» размывает грань между сознательным критическим отношением к гомосексуализму, основанном на убеждениях, и формами проявления агрессии, смещая ассоциативное восприятие в сторону агрессии и психопатологии. Для использования в отечественной научной литературе, посвященной изучению данного вопроса предлагаются термины «критическое отношение», «негативизм» или «скептицизм».Область применения результатов. Результаты исследования могут быть применены в общественно-политическом дискурсе, направленном на защиту и развитие базовых нравственных и социальных ценностей.
Use of clinical photography in dentistry
Authors: Henderson Kelly
Published: November 2018

Kelly Henderson considers how photography as a dental record can aid your practice, clinical skills and become your indisputable evidence should you need it.
HUBUNGAN PANJANG DAN BERAT, FAKTOR KONDISI , FEKUNDITAS, DAN PERKEMBANGAN TELUR IKAN TENGADAK (Barbonymus schwanenfeldii) DARI SAROLANGUN, JAMBI DAN ANJONGAN, KALIMANTAN BARAT, INDONESIA
Authors: Kusmini Irin Iriana , Subagja Jojo , Putri Fera Permata
Published: November 2018

Tinfoil barb (Barbonymus schwanenfeldii) is one of the potential local fish to be cultivated as a food or pet fish. The data and information of the growth pattern of species are essential for fish farming success. The observation on the length and weight relationship is an usefull indicator to determine the pattern of growth fish observed. This study aims to determine the growth patterns of tinfoil barb fish based on length and weight relationship, condition factor and fish fecundity of tinfoil barb from Sarolangun, Jambi and Anjongan, West Kalimantan. The 30 samples were taken randomly from each group. Data were analyzed using analysis regression Microsoft Excel. The result showed that the regression coefficient of length and weight relationship was 2.811 for Sarolangun and 2.686 for Anjongan. The regression value indicates that the the growth of tinfoil barb was allometric negative, with an average factor condition ranged from 0.99 to 1.002. Length and weight relationship had determinant value (R2) ranged from 0.79 to 0.96, with the fecundity ranged from 20168 to 232.040 eggs from 9–45.5g of gonad weight.
KARAKTERISASI KERAGAMAN GENETIK 27 GENOTIPE CABAI BERDASARKAN MARKA SSR (SIMPLE SEQUENCE REPEAT)
Authors: Terryana Rerenstradika Tizar , Nugroho Kristianto , Rijzaani Habib , Lestari Puji
Published: November 2018

Chili pepper (Capsicum annuum) is one of the high economical horticultural comodity in Indonesia and its genetic diversity contributes to the success of breeding programs. Simple sequence repeat (SSR) markers can be used to analyze genetic diversity among chili pepper genotypes. The aim of this research was to analyze the genetic diversity of twenty-seven genotypes of chili pepper by using 24 SSR markers. The collected data was analyzed using cluster analysis and principle coordinate analysis (PCoA). The result showed that high allele variation (4–17 alleles) was observed among chili pepper genotypes tested, with an average allele number and Polymorphism Information Content (PIC) value was 7.708 and 0.758 (0.598–0.920) respectively. All of SSR markers showed PIC value >0.5 which indicated that these markers were suitable for chili pepper diversity studies with a high differentiation and with the average value of genetic diversity was 0.78. The clustering and principle coordinate analysis showed that twenty-seven genotypes of chili pepper were divided into two groups (coefficient of similarity 0.74 in cluster analysis) indicating a high genetic variability among them. Genetic diversity analysis in this study will be useful as an initial basis of selection for appropriate parents with desired traits to assist the breeding program of chili pepper in Indonesia.
Pichia pastoris: SEL RAGI UNTUK PRODUKSI PROTEIN REKOMBINAN
Authors: Herawati Neng , Kusumawati Arizah , Santoso Adi
Published: November 2018

Pichia pastoris is a group of methylotropic yeast known as a host of expression and protein production which is widely used for biopharmaceutical-based drug production. This yeast can grow fast with a high cell density. Its genetic stability, high cell density, and stress resistance make the development process and scale-up of P. pastoris can increase to a scale of 200,000 liters of culture. In contrast to the expensive and complex development of recombinant protein production in mammalian cells, the development of production in P. pastoris is relatively simple and cheaper. The advantage of P. pastoris as an expression system is that it is able to use methanol as a carbon source by inducing the expression of alcohol oxidase oxidase (AOX) enzyme. Promoter used by this enzyme is also used as a strong promoter for the expression of proteins that we want. Unlike in bacterial and mammalian systems, recombinant protein production in Pichia cells is not contaminated with endotoxins or viruses so it is safer and simplifies the downstream processes in bioproduction. The level of endogenous protein in the low supernatant allows Pichia to cultivate with a high volumetric productivity, therefore the process of protein production becomes very economical. This review provides an overview of several things that must be considered in utilizing P. pastoris as an expression system including the selection of vectors, strains, vector integration mechanisms into the genome, glycosylation processes, and applications in industry.
La sutura de los mundos. Políticas del lenguaje en Rubén Darío
Authors: Link Daniel
Published: November 2018

La obra de Rubén Darío es un hito que vuelve a encontrar toda su fuerza en la discusión de los paradigmas hegemónicos en el campo de los estudios comparados, la Weltliteratur, el hispanismo y los estudios transatlánticos, no como caso para ser analizado sino como lugar de enunciación teórica que, como no podía ser de otra manera, anticipa algunos desarrollos de la teoría poscolonial y los estudios subalternos.

Darío (como Caupolicán) no sólo soporta un mundo sobre sus espaldas, sino que interrumpe toda ilusión de homogeneidad y toda arrogancia en relación con algún centro. Nos dice que la lengua y el poema están en un lugar imposible y encuentra en esa imposibilidad un principio teórico, una ontología del presente y de nosotros mismos.
Chuy. Revista de estudios literarios latinoamericanos
Authors: Rosetti Miguel
Published: November 2018

Chuy. Revista de estudios literarios latinoamericanos.
El efecto del exilio en las obras de Juan José Saer y Daniel Moyano. Propuesta metodológica para analizar procesos redaccionales y de archivo
Authors: Viña Diego , Bernabei Verónica
Published: November 2018

Este trabajo se centra en las obras y los archivos de Juan José Saer y Daniel Moyano, a partir de algunos interrogantes y de una propuesta metodológica en torno a los procesos escriturales y de archivación que tienen como cuestión de fondo el efecto del exilio en la obra de un autor. A la hora de analizar dichos procesos utilizando como punto de partida un archivo de obra, encontramos que una disposición en el espacio de los datos permite comprender hiatos o blancos que se destacan en una cronología establecida a partir de la lectura. Estas reflexiones se sostienen, por tanto, en una indagación sobre la temporalidad de la escritura y su materialización a partir de un dimensionamiento espacial de los documentos. Nos preguntamos cómo es posible ver la escritura; esto es, cómo se pueden representar y explicar, en el espacio, las vicisitudes literarias, editoriales y vivenciales que conforman el recorrido de un escritor. Y a partir de esto, cómo es posible ver la evolución de un archivo a medida que los investigadores intervienen los documentos.

Para responder a los interrogantes proponemos articular documentos pre–redaccionales y redaccionales inventariados y organizados que conforman nuestro objeto «literario» con otros documentos, fechas y datos contextuales en torno a los autores. Lo hacemos partiendo de un modelo gráfico que elaboramos para dilucidar los procesos redaccionales en la obra de Saer, en principio, y que luego extendimos a la escritura y el archivo de Moyano. Las dos cronologías permiten ver la incidencia que puede tener la constitución de un fondo documental para ampliar o desocultar distintas facetas o períodos de producción.
Memoria y otras cuestiones, más crónica de una experiencia
Authors: Manzoni Celina
Published: November 2018

En el marco de una reflexión sobre la teoría literaria latinoamericana enseñada en la universidad argentina, este trabajo recupera la brevísima experiencia realizada en 1973 en las entonces denominadas «cátedras nacionales». Ese año fui auxiliar docente en la cátedra dirigida por Noé Jitrik, Literatura Iberoamericana, que no integraba ese espectro, aunque es indudable que participaba de la voluntad de renovación e incluso del fervor que caracterizó el momento. Algunos de los invitados a formar parte de la cátedra veníamos de cursos privados de teoría literaria dictados por Jitrik en los que, a los textos mayores del estructuralismo y las polémicas que lo rodearon, bastante transitadas entonces, se sumaron algunos autores de lo que sería llamado posestructuralismo. La cátedra de Literatura Iberoamericana estuvo organizada en torno a tres campos (crítico, teórico y contextual) que, más o menos coordinados, dictaban los tres profesores (Jitrik, Ludmer, Ruffinelli) en las respectivas clases teóricas: un ingreso a los textos desde enfoques diversos y eventualmente complementarios que se ponían en discusión en los prácticos. Una experiencia intensa quebrada por la prepotencia de una historia que corresponde recuperar no solo desde las memorias, sino desde la materialidad de la letra de los programas, de la bibliografía y de las metodologías enseñadas.
Im Auftrag des Rechts. Christliche und jüdische Regensburger Anwälte beim Innsbrucker Prozess (1516-1519)
Authors: Nickel Veronika
Published: November 2018

The expulsion of the Jewish Community from Regensburg (Ratisbon) in 1519 was one of the last and well-known expulsions of Jews from an Imperial City on the brink of the modern era. Little attention has been paid to a lawsuit between the Regensburg City Council and the Jewish Community which was initiated three years before 1519. Both the City Council and the Jewish Community sent specially authorised delegates as attorneys to attend the trial held in front of the Regiment in Innsbruck/Austria. Hans Hirsdorfer, Hansgraf of Regensburg, was usually dispatched to Innsbruck as the Christian representative while Isaak Walch made the journey in order to represent the Jewish Community. Their powers of attorney, along with other sources such as account books, give us deep insights into their scope of action regarding personal as well as juridical matters.
A report of chronic intestinal pseudo-obstruction related to systemic lupus erythematosus
Authors: Wang Ruiqiang , Zheng Bowen , Wang Biyue , Ma Pupu , Chen Fengmei , Tang Lin
Published: November 2018

Chronic intestinal pseudo-obstruction (CIPO) is a functional gastrointestinal disorder with symptoms of ileus. CIPO can either be idiopathic or secondary to other diseases such as systemic lupus erythematosus (SLE). SLE is involved in many parts of the gastrointestinal system with variable clinical presentations. Reports about reduplicated CIPO as a complication of SLE is infrequent. A 49-year-old female suffering from clinical symptoms of ileus has been hospitalized 3 times over 1 year. Her examination results showed no observation of mechanical obstruction. In August 2017, she came to the nephrology department due to edema in both lower limbs along with symptoms of ileus. After thorough examination, she was diagnosed with secondary CIPO related to SLE. Results of renal biopsy confirmed to be lupus nephritis (Class III-(A) + V). The symptoms of ileus are gradually improved after treatment of full-dose intravenous corticosteroid for 5 days.
Using superoscillations for superresolved imaging and subwavelength focusing
Authors: Gbur Greg
Published: November 2018

It is now well-appreciated that a bandlimited wave can possess oscillations much more rapidly than those predicted by the bandlimit itself, in a phenomenon known as superoscillation. Such superoscillations are required to be of dramatically smaller amplitude than the signal they are embedded in, and this has initially led researchers to consider them of limited use in applications. However, this view has changed in recent years and superoscillations have been employed in a number of systems to beat the limits of conventional diffraction theory. In this review, we discuss the current state of research on superoscillations in terms of superresolved imaging and subwavelength focusing, including the use of special non-diffracting and Airy beams to carry transverse superoscillating patterns. In addition, we discuss recent analogous works on using superoscillations to break the temporal resolution limit, and also consider the recently introduced inverse of superoscillations, known as suboscillations.
An inverse approach to the characterisation of material parameters of piezoelectric discs with triple-ring-electrodes
Authors: Feldmann Nadine , Jurgelucks Benjamin , Claes Leander , Schulze Veronika , Henning Bernd , Walther Andrea
Published: November 2018

For its usage in simulation-based design processes a precise knowledge of the employed material properties is inevitable. In the case of piezoelectric ceramics, the provided material parameters often suffer from large uncertainties and even inconsistencies since the standardised measurement procedure needs several specimens to determine a single set of material parameters. In contrast, the presented measurement set-up allows to calculate material parameters using one unique disc-shaped specimen with an optimised electrode topology. Using an inverse problem approach, fitting material parameters can be found using an optimisation procedure.
Feasibility of Improving the Mechanical Properties of Concrete Pavement Using Basalt Fibers
Authors: Sarkar Alireza , Hajihosseini Majid
Published: November 2018

Many research studies have so far been done to improve the mechanical properties of concrete pavement by using basalt fiber; these studies have indicated the positive effects of this fiber on concrete pavements. Accordingly, the idea of applying this fiber, which is proportional to the concrete mix design and is commonly used in this geographical area, was introduced. Therefore, based on the type and amount of basalt fiber content recommended in the technical literature, the effect of using this fiber in two conventional mix designs was evaluated. In order to determine the effect of the fiber on mechanical properties affecting pavement design, the influence of the alkaline environment of cement on the fiber was initially examined. Then, concrete samples containing this fiber are subjected to tensile, compression, and bending tests. The results showed that in the mix design commonly used in this area, the use of basalt fiber in accordance with the recommended amounts indicated in most studies may lead to a minor improvement in the toughness index and indirect tensile strength of concrete samples and to negative effects on four-point bending and compressive strength.
Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity
Authors: Huijbers Willem , Schultz Aaron P. , Papp Kathryn V. , LaPoint Molly R. , Hanseeuw Bernard , Chhatwal Jasmeer P. , Hedden Trey , Johnson Keith A. , Sperling Reisa A.
Published: November 2018

Animal studies demonstrate that hyperactive neurons facilitate early accumulation and spread of tau and amyloid-β proteins in the pathological cascade of Alzheimer's disease (AD). Human neuroimaging studies have linked hippocampal hyperactivity to amyloid-β accumulation, apolipoprotein ε4 (APOE4) and clinical progression from prodromal AD to clinical dementia. The relationship between hippocampal hyperactivity and early AD molecular pathology (amyloid-β and tau accumulation) before clinical symptoms remains to be elucidated. Here, we studied 120 clinically normal older humans (80 females/40 males) enrolled in the Harvard Aging Brain Study. We measured functional magnetic resonance imaging (fMRI) activity during successful memory encoding and amyloid-β accumulation with PiB-positron emission tomography imaging. Additionally, we measured tau accumulation using AV1451 PET imaging in a subset of 87 participants. In this subset, we found that inferior temporal tau accumulation was associated with increased fMRI activity in the hippocampus, but showed no clear association with amyloid. Together, the findings support a hypothetical model of the evolution of preclinical AD that place hippocampal hyperactivity concurrent with spread of tau pathology to neocortical regions before clinical impairment.

SIGNIFICANCE STATEMENTThe circumstances under which the hippocampus becomes hyperactive in preclinical stages of Alzheimer's disease (AD) have thus far remained elusive. Recent advances in positron emission tomography (PET) tracers now enablein vivocharacterization of amyloid-β and tau accumulation. Here, we combine amyloid and tau PET with functional magnetic resonance imaging (fMRI) to examine the association between Alzheimer's disease pathology and memory-related brain activity in clinically normal older adults. We found an association between increased hippocampal activity and tau accumulation in the inferior temporal cortex. These data suggest that the pathogenesis of hippocampal hyperactivity occurs concurrent with the spread of tau pathology from the entorhinal cortex to the neocortex, before the clinical manifestations of Alzheimer's disease.
Genes and Protein Synthesis—Updating Our Understanding
Authors: Brady Timothy P.
Published: November 2018

That genes are indispensable is indisputable but that they are the source of information for protein synthesis—to the extent reflected by statements such as “genes are blueprints for proteins” or “genomes constitute developmental programs”—is challenged by discoveries such as post-translational modification of protein and alternative splicing.
Psychological and Musical Factors Underlying Engagement with Unfamiliar Music
Authors: Janata Petr , Peterson Joshua , Ngan Clinton , Keum Bokyoung , Whiteside Hannah , Ran Sonia
Published: November 2018

What are the factors that determine how long a person chooses to listen to an unfamiliar piece of music? We examined this question across three experiments in which we played participants novel repeating multi-instrument stimuli and recorded their listening times and reasons for their decisions to either continue or stop listening. To influence the habituating effects of repeating musical material drawn from a large stimulus library (> 450 items), we manipulated novelty along several musical dimensions. In Experiment 1, all instruments entered simultaneously. In Experiment 2, instrument entrances were also offset in time. In Experiment 3, we composed core multi-instrument loops and manipulated them to further minimize harmonic variability, minimize rhythmic variability, introduce spatialization, or change timbral characteristics. Novelty introduced by instrument entrances was the strongest determinant of listening times, though harmonic variability and timbral features were also important. Subjective enjoyment was the best predictor of listening times, mediating the effects of the degree of perceived groove in a stimulus, the urge to move, interest in a stimulus, perceived complexity, and congruency with current mood. We conclude that naturalistic looping musical stimuli serve well to examine the diverse psychological and musical determinants of choice behavior underlying music consumption.
Simulation of fluid sloshing in a tank using the SPH and Pendulum methods
Authors: Vidmar Vesna , Petkovšek Gregor , Žagar Dušan
Published: November 2018

We simulated liquid sloshing in a circular road tanker during two typical manoeuvres, namely steady-turn and lane change. A quasi-static pendulum, a modified dynamic pendulum with adjustable rod length, and the SPH (Smooth Particle Hydrodynamics) model Tis Isat were applied to simulate liquid oscillations. A simplified vehicle-tanker overturning model was developed and applied in order to determine the overturning threshold for the first manoeuvre. The agreement of liquid oscillations between the applied methods was better in the second manoeuvre, while the maximum inclination of the liquid gravity centre was successfully simulated in both cases. Both dynamic methods, the SPH and the dynamic pendulum, show a significantly lower overturning threshold, while all methods show similar overturning behaviour for a vehicle with liquid cargo. The threshold computed using the SPH model is slightly higher than with the dynamic pendulum due to wall-particle and particle-particle interactions. The results and comparisons confirm the suitability of the SPH method for simulating sloshing in road tankers and also show the method’s advantages: realistic description of the non-linear free surface in real-time, along with a consideration of mixing and friction processes within the fluid.
LHX3 deficiency presenting in the United States with severe developmental delay in a child of Syrian refugee parents
Authors: Ahern Susan , Daniels Mark , Bhangoo Amrit
Published: November 2018

In this case report, we present a novel mutation in Lim-homeodomain (LIM-HD) transcription factor, LHX3, manifesting as combined pituitary hormone deficiency (CPHD). This female patient was originally diagnosed in Egypt during infancy with Diamond Blackfan Anemia (DBA) requiring several blood transfusions. Around 10 months of age, she was diagnosed and treated for central hypothyroidism. It was not until she came to the United States around two-and-a-half years of age that she was diagnosed and treated for growth hormone deficiency. Her response to growth hormone replacement on linear growth and muscle tone were impressive. She still suffers from severe global development delay likely due to delay in treatment of congenital central hypothyroidism followed by poor access to reliable thyroid medications. Her diagnosis of DBA was not confirmed after genetic testing in the United States and her hemoglobin normalized with hormone replacement therapies. We will review the patient’s clinical course as well as a review of LHX3 mutations and the associated phenotype.

Learning points:

Describe an unusual presentation of undertreated pituitary hormone deficiencies in early life

Combined pituitary hormone deficiency due to a novel mutation in pituitary transcription factor, LHX3

Describe the clinical phenotype of combined pituitary hormone deficiency due to LHX3 mutations
Reducing the IT Personnel's Workload in IT Self-Services
Authors: Bär Florian , Leyer Michael , Sandkuhl Kurt
Published: November 2018

IT operations aims to reduce the IT personnel’s workload in IT self-services, which is not self-evident. This study explores how the IT personnel’s workload can be reduced in IT self-services. A multiple-case study with five IT self-services was conducted. Data was collected from two German IT service providers and a European software company. The problem causing a non-reduction of the IT personnel’s workload in IT self-services is a lack of service production control and it is rooted in knowledge and skill gaps and a free IT self-service outcome. The two solutions to that problem comprise the adoption of five behavioral patterns: chargeback and limitation, standardization of the IT self-service, authorization of employee orders, showback, and training and support. This study is first revealing the mechanisms how IT self-services can be operated successfully from a service operations perspective.
Addressing 21st Century Communication Skills: Some Emerging Issues from Eil Pedagogy & Intercultural Communicative Competence
Authors: PATTIWAEL Athriyana Santye
Published: November 2018

ABSTRACT 21st Century Skills has attracted the attention of various education experts, practitioners, school management, teachers and educational managers in ASEAN countries, including Indonesia. A number of activities in terms of seminars and workshops have been held by a wide range of institutions to address this framework in terms of how to align it to the curriculum and how to integrate it into classroom activities. Regarding communication skills, Partnership for 21st Century Skills defines 21st Century Communication Skills – among the other five definitions – as communicating effectively in diverse environments (including multilingual and multicultural). Realizing that this framework was developed in the American context for their national education purposes, it is imperative for various parties, including teachers and practitioners of English as a Foreign Language, to contextualize it by considering both local and regional contexts. As a minute contribution to the effort of contextualizing the framework, this paper will address some emerging issues in developing the instructional materials framed by the pedagogy of English as an International Language and Intercultural Communicative Competence. ABSTRAK Keterampilan Abad ke-21 telah menarik perhatian beragam kalangan dari pakar pendidikan, praktisi, pengelola sekolah, guru sampai para manajer institusi pendidikan di negara-negara ASEAN, termasuk Indonesia. Serangkaian kegiatan termasuk seminar dan workshop telah diselenggarakan oleh berbagai institusi untuk membedah kerangka kerja ini dalam  hal Tentang keterampilan berkomunikasi, Partnership for 21st Century Skills mendefinisikan  keterampilan Komunikasi Abad ke-21 -di antara lima definisi lainnya– sebagai kemampuan berkomunikasi secara efektif di berbagai lingkungan (termasuk multibahasa dan multikultural). Menyadari bahwa kerangka kerja ini dikembangkan dalam konteks Amerika untuk tujuan pendidikan nasional mereka, maka sangatlah penting bagi berbagai pihak, termasuk guru dan praktisi bahasa Inggris sebagai bahasa asing, untuk mengkontekstualisasikannya dengan mempertimbangkan konteks lokal dan regional. Sebagai kontribusi kecil terhadap upaya kontekstualisasi tersebut, tulisan ini akan membahas beberapa isu yang muncul dalam pengembangan bahan ajar yang dibingkai oleh pedagogi Bahasa Inggris sebagai Bahasa Internasional dan Kompetensi Komunikasi Antar-budaya. How to Cite: Pattiwael, A., S. (2016). Addressing 21st Century Communication Skills: Some Emerging Issues from Eil Pedagogy & Intercultural Communicative Competence. IJEE (Indonesian Journal of English Education), 3(2), 158-170 doi:10.15408/ijee.v3i2.3164. Permalink/DOI: http://dx.doi.org/10.15408/ijee.v3i2.3164
The Application of Language Learning Strategies of High School Students In Indonesia
Authors: A. Alfian
Published: November 2018

ABSTRACT The purpose of this study is to investigate language learning strategies (LLS) use by high school students in Indonesia. By employing a mixed-method design, eighty  participants responded to the Strategy Inventory of Language Learning (SILL) questionnaire for the quantitative data. Eight  language learners were interviewed for qualitative data. The descriptive statistics using SPSS was used to analyze the questionaire, and thematic analysis was used  to analyze the interviews. The results indicated that first; metacognitive, cognitive and social strategies use were reportedly employed the most frequently of all strategies. Second, the strategies employed by males participants are not different with those employed by females Third, successful students used more strategies than those of less successful students. The interview findings demonstrated  that successful language learners mostly used practicing strategies ( practice four language skills). This study provides the implication for classroom practice, especially raising teacher’s awareness of their teaching methodology. ABSTRAK Tujuan dari penelitian ini adalah untuk mengetahui strategi-strategi  pembelajaran bahasa yang digunakan oleh siswa SMA di Indonesia. Penelitian ini menerapkan metode mix-method dimana  Delapan Puluh telah mengisi angket strategi belajar bahasa (SILL) untuk data kuantitatif dan Delapan siswa telah diwawancarai untuk data kualitatif. Data dari angket dianalisa dengan SPSS sedangkan metode analisis tematik digunakan untuk menganalisis hasli wawancara. Hasil penelitian ini menunjukkan bahwa pertama; Metakognitif, kognitif dan strategi sosial dilaporkan paling sering digunakan dari semua strategi pembeljaran bahasa. Kedua, strategi yang digunakan oleh siswa laki-laki tidak berbeda dengan yang laporkan oleh siswa perempuan. Ketiga, siswa yang sukses dalam pembelajaran bahasa  menggunakan lebih banyak strategi daripada siswa yang kurang sukses. Dari hasil wawancara didapatkan bahwa pelajar bahasa yang berhasil kebanyakan menggunakan strategi berlatih (berlatih empat keterampilan bahasa). Penelitian ini memberikan implikasi untuk proses belajar mengajar dalam  kelas, terutama untuk meningkatkan kesadaran guru terhadap pemilihab metodologi pengajaran mereka. How to Cite: Alfian. (2016). The Application of Language Learning Strategies of High School Students In Indonesia. IJEE (Indonesian Journal of English Education), 3(2), 140-157 doi:10.15408/ijee.v3i2.5509. Permalink/DOI: http://dx.doi.org/10.15408/ijee.v3i2.5509
Utilizing Cooperative Learning in Islamic College Students’ Classroom
Authors: Marzuki Abdul Gafur
Published: November 2018

ABSTRACT The research aims at utilizing cooperative learning in teaching reading skill for Islamic college students. The research was classroom action research which was conducted in two cycles where each cycle consisted of planning, implementation, observation and reflection. The subject were taken from PAI 5 which contained 30 students. The data of this research were obtained from the test, observation checklist, and field notes. The findings of research showed that cooperative learning was effective in developing students’ reading skill. The findings revealed that there were nineteen students who achieved the minimum criteria of achievement in cycle 1, which percentage was 63.3%. In cycle 2, it was found that there were twenty five students who achieved the minimum criteria of achievement, which percentage increased to 83.3%. Both of the classical and individual achievements have met the criteria of success. Besides, students were active in joining classroom activities and completing their classroom tasks. Therefore, it can be concluded that the cooperative learning was effective to develop the students’ reading skill. ABSTRAK Penelitian ini bertujuan untuk memanfaatkan pembelajaran kooperatif dalam pembelajaran keterampilan membaca mahasiswa di perguruan tinggi Islam. Penelitian ini merupakan penelitian tindakan kelas yang dilakukan dalam dua siklus dimana setiap siklus terdiri dari perencanaan, pelaksanaan, observasi dan refleksi. Subjek penelitian diambil dari kelas PAI 5 yang terdiri dari 30 mahasiswa. Data penelitian ini diperoleh dari hasil tes, lembar observasi, dan catatan lapangan. Temuan penelitian menunjukkan bahwa pembelajaran kooperatif efektif dalam mengembangkan keterampilan membaca mahasiswa. Temuan menunjukkan bahwa ada sembilan belas mahasiswa yang mencapai kriteria pencapaian minimal pada siklus 1, dengan persentase 63,3%. Pada siklus 2, ditemukan bahwa ada dua puluh lima mahasiswa yang mencapai kriteria pencapaian minimum dengan persentase 83,3%. Persentase klasik dan individual telah memenuhi kriteria keberhasilan. Selain itu, mahasiswa aktif mengikuti kegiatan kelas dan menyelesaikan tugas kelas mereka. Oleh karena itu, dapat disimpulkan bahwa pembelajaran kooperatif efektif untuk mengembangkan keterampilan membaca mahasiswa. How to Cite: Marzuki, A., G. (2016). Utilizing Cooperative Learning in Islamic College Students’ Classroom. IJEE (Indonesian Journal of English Education), 3(2), 123-139 doi:10.15408/ijee.v3i2.5528. Permalink/DOI: http://dx.doi.org/10.15408/ijee.v3i2.5528
The Influence of Prior Knowledge on Students’ Listening and Reading Comprehension
Authors: Hasan Abdullah , Gushendra Rizky , Yonantha Ferri
Published: November 2018

ABSTRACTThe research aims to investigate the influence of prior knowledge on students’ listening and reading comprehension at the tenth year of MAN 1 Pekanbaru. This study is a correlational research that involved 75 respondents as a sample from 150 students of the the tenth year of Science classes as the total population. The respondents were selected by using a simple random sampling technique. 20 items of multiple choice of listening test and 20 items of multiple choice of reading test and 15 items of the prior knowledge questionnaire were used to collect the data. Afterwards, the data were further analyzed by using Pearson product moment correlation for the first and the second hypotheses and MANOVA (Multivariate Analysis of Variance) for the third hypothesis by using SPSS 25. The research findings revealed that the mean score of students’ prior knowledge is 73.41 and is categorized as “Good”, their listening comprehension is 68.13 and is categorized as “Good”, and their reading comprehension is 70.67 and it is also categorized as “Good”. It can be seen that the value of Sig. (2-tailed) is 0.000<0.05. Lastly, for the third hypothesis, the value of significance is 0.000<0.05. It means Ha is accepted. Then, it is generated that there is a significant influence of prior knowledge on both students’ listening comprehension and reading comprehension.ABSTRAKPenelitian  ini  bertujuan untuk  mengetahui pengaruh pengetahuan yang ada pada siswa terhadap pemahaman listening dan speaking siswa kelas X MAN 1 Pekanbaru. Kajian ini merupakan penelitian korelasi yang terdiri dari 75 responden sebagai sampel dari populasi 150 orang siswa kelas X jurusan IPA dengan menggunakan tehnik sampel acak. tes Listening  dan Reading menggunakan pilihan ganda yang masing-masingnya terdiri dari 20 soal. Kuesioner digunakan untuk mengumpulkan data. Kuesioner ini terdiri dari 15 pernyataan. Selanjutnya data dianalisa dengan menggunakan korelasi Pearson Product Moment untuk hipotesis yang pertama dan kedua, sedangkan untuk menganalisa hipotesis yang ketiga menggunakan MANOVA (Multivariate Analysis of Variance) SPSS versi 25. Hasil penelitian mengungkapkan nilai rata-rata pengetahuan yang sudah ada adalah 73.41 dan dikategorikan “Baik”. Nilai rata-rata listening comprehension  68.13 dan dikategorikan “Baik” serta nilai rata-rata reading comprehension 70.67 dan juga dikategorikan “Baik”  Dapat diketahui bahwa nilai signifikan (2;tailed) adalah 0.000<0.05. Akhirnya, untuk hipotesa yang ketiga nilai signifikannya 0.000<0.05. Hasil ini menunjukkan bahwa Ha diterima. Kemudian, disimpulkan bahwa terdapat pengaruh yang signifikan prior knowledge siswa terhadap listening dan reading comprehension. How to Cite: Hasan, A. Gushendra, R. Yonantha, F. (2017). The Influence of Prior Knowledge on Students’ Listening and Reading Comprehension. IJEE (Indonesian Journal of English Education), 4(1), 1-15 doi:10.15408/ijee.v4i1.4744.DOI: http://dx.doi.org/10.15408/ijee.v4i1.4744
READING STRATEGIES AS DEVELOPMENT MODEL ENGLISH COGNITION OF SENIOR HIGH SCHOOL STUDENTS
Authors: Supeno S , Suseno Imam , Alhamidi Lubban Anwari
Published: November 2018

ABSTRACT This study aims to develop a model of reading strategies of English language learning which is expected to further enhance students’ cognitive abilities in English. The model reading strategies serve as a strategy to read the English subtitles via bottom-up, top-down and mixed strategies that are capable of triggering the students' critical thinking and have been integrated with development ideas from experts and linguists. The study employed a cluster random sampling of 30 schools and 900 students for the standardization of the model reading strategies as a new model that best enhance the cognitive power of English language learning. The method used was Research and Development, through  seven steps in the research cycles. The subjects were high school students in the class tenth in  Special Capital Region of Jakarta. The steps to reading development strategy that are able to improve the cognitive of students are 6 steps consisting of:  overall understanding,  understanding on contextual meaning,  assumption of contextual meaning,  look for meaning in contextual output,  searching for further meaning, and  returning to the main idea of ​​our thinking.   ABSTRAK Penelitian ini bertujuan mengembangkan model pembelajaran bahasa Inggris yakni reading strategies, yang diharapkan dapat meningkatkan daya kognitif bahasa Inggris siswa. Permodelan reading strategies sebagai strategi untuk membaca teks bahasa Inggris melalui strategi bottom-up, top-down dan mixed yang mampu memicu pemikiran kritis siswa dan telah diintegrasikan dengan gagasan pengembangan dari para ahli dan ahli bahasa. Dengan cluster random sampling terpilih sebanyak 30 sekolah dan 900 siswa untuk standarisasi model reading strategies sebagai model baru yang dapat meningkatkan daya kognitif bahasa Inggris siswa. Metode yang digunakan adalah Research and Development, melalui tujuh langkah dalam siklus penelitian. Subjek penelitian adalah siswa SMA di kelas sepuluh di DKI Jakarta. Hasil penelitian menunjukkan bahwa reading strategies yang dapat meningkatkan kemampuan kognitif siswa yaitu melalui adalah 6 langkah strategi membaca yaitu:  pemahaman teks secara utuh, memahami makna dalam konteks, berpikir dan menduga tentang makna, mencari makna dalam konteks, mencari makna lebih jauh, dan kembali pada pemikiran makna kata. How to Cite: Supeno. Suseno,I. Alhamidi, L. A. (2017). Reading Strategies as Development Model English Cognition of Senior High School Students. IJEE (Indonesian Journal of English Education), 4(1), 84-96, doi:10.15408/ijee.v4i1.4822DOI: http://dx.doi.org/10.15408/ijee.v4i1.4822