bluuebunny/crossref_metadata_2025 huggingface dataset:
Agronomic feasibility of wheat and triticale cultivars in the semiarid of Minas Gerais State, Brazil
Authors: Santos Adson , Albuquerque Carlos , Sousa Franklin , Siqueira Raphael , Rocha Fernando , Custodio Adriano
Published: February 2023

The production of winter cereals is becoming increasingly important in Brazil, largely due to advanced techniques that enable considerable qualitative and quantitative gains. This is due to plant breeding under different soil and climate conditions combined with proper management. The present study aims to assess the agronomic feasibility of growing wheat and triticale cultivars with two sowing times in the semiarid region of northern Minas Gerais State, Brazil. The experiment was conducted in 2018 at the Instituto de Ciências Agrárias (Institute of Agricultural Sciences) of Universidade Federal de Minas Gerais, Montes Claros campus.  A randomized block design was used, with four replications and an 8 × 2 factorial arrangement consisting of eight genotypes (six wheat and two triticale cultivars) and two sowing times (April 21 and May 12, 2018). The irrigated production of wheat and triticale was agronomically feasible in the semi-arid region of Minas Gerais state and sowing time affected the main agronomic traits of interest of winter cereals. However, it is essential to study the economic feasibility of the crop. Sowing in April was the most indicated for wheat and triticale, with IPR Potyporã, IPR 144 and IPR 111 as the recommended cultivars.
The Relationship Between Testosterone Therapy and Rotator Cuff Tears, Repairs, and Revision Repairs
Authors: Testa Edward J. , Albright J. Alex , Hartnett Davis , Lemme Nicholas J. , Daniels Alan H. , Owens Brett D. , Arcand Michel
Published: February 2023

Introduction:

The purpose of this study was to evaluate rates of rotator cuff tears (RCTs), repairs (RCRs), and revision RCR in patients who were prescribed testosterone replacement therapy (TRT) and compare these patients with a control group.

Methods:

The PearlDiver database was queried for patients who were prescribed testosterone for at least 90 days between 2011 and 2018 to evaluate the incidence of RCTs in this population. A second analysis evaluated patients who sustained RCTs using International Classification of Diseases, 9th/10th codes to evaluate these patients for rates of RCR and revision RCR. Chi square analysis and multivariate regression analyses were used to compare rates of RCTs, RCR, and subsequent or revision RCR between the testosterone and control groups, with a P-value of 0.05 representing statistical significance.

Results:

A total of 673,862 patients with RCT were included for analysis, and 9,168 of these patients were prescribed testosterone for at least 90 days before their RCT. The TRT group had a 3.6 times greater risk of sustaining an RCT (1.14% versus 0.19%; adjusted odds ratio (OR) 3.57; 95% confidence interval (CI) 3.57 to 3.96). A 1.6 times greater rate of RCR was observed in the TRT cohort (TRT, 46.4% RCR rate and control, 34.0% RCR rate; adjusted OR 1.60; 95% CI 1.54 to 1.67). The TRT cohort had a 26.7 times greater risk of undergoing a subsequent RCR, irrespective of laterality, within 1 year of undergoing a primary RCR when compared with the control group (TRT, 47.1% and control, 4.0%; adjusted OR 26.4; 95% CI 25.0 to 27.9, P < 0.001).

Conclusions:

There is increased risk of RCTs, RCRs, and subsequent RCRs in patients prescribed testosterone. This finding may represent a musculoskeletal consequence of TRT and is important for patients and clinicians to understand. Additional research into the science of tendon injury in the setting of exogenous anabolic steroids remains of interest.

Level of evidence:

Level Ⅲ, retrospective cohort study.
Larger Perioperative Opioid Prescriptions Lead to Prolonged Opioid Use After Hand and Upper Extremity Surgery: A Multicenter Analysis
Authors: Townsend Clay B. , Ly Justin A. , Judy Ryan , Sherman Matthew B. , Elmer Nick , Conroy Christine , Abdelfattah Hesham M. , Solarz Mark K. , Woozley Katharine , Ilyas Asif M.
Published: February 2023

Introduction:

The opioid epidemic remains an ongoing public health crisis. The purpose of this study was to investigate whether surgeons' prescribing patterns of the initial postoperative opioid prescription predispose patients to prolonged opioid use after upper extremity surgery.

Methods:

This multicenter retrospective study was done at three academic institutions. Patients who underwent carpal tunnel release, basal joint arthroplasty, and distal radius fracture open reduction and internal fixation over a 1.5-year period were included. Opioid prescription data were obtained from the Pennsylvania Prescription Drug Monitoring Program website.

Results:

Postoperatively, 30.1% of the patients (191/634) filled ≥1 additional opioid prescription, and 14.0% (89/634) experienced prolonged opioid use 3 to 6 months postoperatively. Patients who filled an additional prescription postoperatively were initially prescribed significantly more pills (P = 0.001), a significantly longer duration prescription (P = 0.009), and a significantly larger prescription in total milligram morphine equivalents (P = 0.002) than patients who did not fill additional prescriptions. Patients who had prolonged opioid use were prescribed a significantly longer duration prescription (P = 0.026) than those without prolonged use.

Conclusion:

Larger and longer duration of initial opioid prescriptions predisposed patients to continued postoperative opioid use. These findings emphasize the importance of safe and evidence-based prescribing practices to prevent the detrimental effects of opioid use after orthopaedic surgery.
Usage of a Value-based Triaging Methodology for Assessing Improvements in Value for Hip Fracture Inpatient Episodes of Care From 2014 to 2019: A Pilot Study
Authors: Konda Sanjit R. , Ranson Rachel , Denasty Adwin , Egol Kenneth A.
Published: February 2023

Introduction:

The purpose of this study was to demonstrate a novel technology used to measure improvements in quality and value of care for treatment of hip fracture patients.

Methods:

A novel value-based triaging methodology uses a risk prediction (risk M) and inpatient cost prediction (risk C) algorithm and has been demonstrated to accurately predict high-risk:high-cost episodes of care. Two hundred twenty-nine hip fracture patients from 2014 to 2016 were used to establish baseline length of stay (LOS) and total inpatient cost for each (16) risk:cost quadrants. Two hundred sixty-five patients between 2017 and 2019 with hip fractures were input into the algorithm, and historical LOS and cost for each patient were calculated. Historical values were compared with actual values to determine whether the value of the inpatient episode of care differed from the 2014 to 16 cohort.

Results:

When evaluated without risk or cost stratification, the mean actual LOS and cost of the baseline cohort compared with the 2017 to 2019 cohort were 8.0 vs 7.5 days (P = 0.43) and $25,446 vs $29,849 (P = 0.15), respectively. This analysis demonstrates that there was only a small change in value of care provided to patients based on LOS/cost over the studied period; however, risk:cost analysis using the novel methodology demonstrated that for select risk:cost quadrants, value of care measured by LOS/cost improved, whereas for others it decreased and for others there was no change.

Conclusion:

Risk-cost–adjusted analysis of inpatient episodes of care rendered by a value-based triaging methodology provides a robust method of assessing improvements and/or decreases in value-based care when compared with a historical cohort. This methodology provides the tools to both track hospital interventions designed to improve quality and decrease cost as well as determine whether these interventions are effective in improving value.
The Impact of Sex on the Outcomes of Prosthetic Joint Infection Treatment with Debridement, Antibiotics and Implant Retention: A Systematic Review and Individual Patient Data Meta-analysis
Authors: Choong Annabelle L. , Shadbolt Cade , Choong Emma , Spelman Tim , Muñoz-Mahamud Ernesto , Lora-Tamayo Jaime , Kim Katy , Wouthuyzen-Bakker Marjan , Spangehl Mark , Chayakulkeeree Methee , Young Simon W. , Choong Peter F. M. , Dowsey Michelle M.
Published: February 2023

Background:

The influence of sex on the failure of débridement antibiotics and implant retention (DAIR) for treating prosthetic joint infection (PJI) is important for decision-making, patient counseling, and equitable health care. However, very few studies in the orthopaedic literature conduct sex-specific analyses.

Aim:

The primary aim was to determine whether sex influences treatment success after DAIR.

Methods:

A systematic review and individual patient data (IPD) meta-analysis was conducted. MEDLINE (Ovid), EMBASE (Ovid), Web of Science, and Google Scholar were searched, and IPD was requested via e-mail. Patients who underwent DAIR after developing PJI within 12 months of a primary total hip or knee arthroplasty were included in the analysis. Treatment failure was defined by the Delphi International Consensus criteria. Adjusted odds ratios for treatment failure were calculated using a mixed-effects logistic regression.

Results:

The study collected and analyzed IPD of 1,116 patients from 21 cohorts. The odds of treatment failure were 29% lower in women (odds ratio, 0.71; 95% CI 0.54 to 0.017; P = 0.017), after adjusting for duration of symptoms >7 days and Staphylococcus aureus infection (methicillin-susceptible Staphylococcus aureus or any infection with S aureus). None of the 64 studies included in the systematic review conducted a sex-specific analysis.

Conclusion:

For patients who developed a PJI within 1 year postsurgery, females have lower odds of DAIR failure than males. Other factors also have varying effects on outcome for men and women. It is essential to implement sex-specific analysis in orthopaedic research.
Systematic Review of Ligament Reconstruction of Traumatic Isolated Thumb Carpometacarpal Joint Dislocation
Authors: Court Tannor , Hussain Kumail , Kim Jennifer Sohjeong , Patel Ishan , Higginbotham Devan O. , Tsai Andrew G.
Published: February 2023

Introduction:

Thumb carpometacarpal (CMC) joint dislocations are rare with minimal agreement on surgical management. The dorsoradial ligament (DRL) is the primary joint stabilizer but has not historically been reconstructed. We hypothesize that the reported reconstruction of first CMC joint dislocations primarily uses the flexor carpi radialis (FCR) without collective agreement on a surgical technique.

Methods:

A systematic review of the PubMed database from 1996 to 2022 was done. Keywords were “thumb dislocation,” “thumb carpometacarpal dislocation,” and “carpometacarpal joint ligament repair.” Inclusion criteria included isolated, unstable thumb CMC dislocations with reconstruction. The Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines were used.

Results:

Four hundred thirty-seven records were identified, and nine met inclusion criteria. Two articles were cohort studies, and seven were case reports. Thirty-seven patients were included, and 26 patients had reconstruction with tendonous autograft. Twenty-five (96.2%) used the FCR and 1 (3.9%) from the palmaris longus. Three patients had reconstruction with a suture anchor. Surgical techniques varied between studies.

Discussion:

The recommendation of the authors recreates the DRL during autograft repair. Current repair techniques that recreate the DRL use the FCR, but quantitative comparisons of tendonous autografts or suture anchors have not been done.
Orthopaedic Surgical Demand Index: A Measure of Need in the United States
Authors: Davison-Kerwood Maxwell , Jiang Sam , Gonzalez1 Mark
Published: February 2023

Background:

Before being evaluated by a physician, more than 50% of patients will search their symptoms on the Google search engine. In fact, Google was the engine used for nearly 90% of all online searches between 2016 and 2018. These search data are stored by Google and can be investigated through google extended trends for health (GETH). The goal of this research was to use GETH to correlate Google search probabilities for elective orthopaedic procedures with the orthopaedic surgeon density in each US state to create a surgical demand index (SDI) that could be then compared between states. In addition, this study aims to assess the effects of annual income, percent minority population, and unemployment rate on that SDI.

Methods:

Google search probabilities were collected using the Google Trends Extraction Tool. Search probabilities were collected in each state for composite search terms. Data were collected in monthly intervals between 2016 and 2018 and averaged. The states were grouped into geographic regions. One-way analysis of variance and pairwise Mann-Whitney U tests were done between these regions. Linear regression analysis was conducted to assess the effect of median annual statewide income, percent minority population, and unemployment rate with SDI.

Results:

The analysis of variance and Mann-Whitney U tests demonstrated a difference between regions. Linear regression analysis revealed a notable effect of median income on SDI, but no effect of percent minority population or unemployment rate.

Conclusions:

The Midwest and South had higher regional demand than the Northeast and West, with West Virginia being the most in need and the District of Columbia being the least in need. Annual median income had a notable negative effect on SDI, whereas percent minority population and unemployment rate had no effect. This study highlights the inequality that exists in the southern and midwestern United States and identifies one potential predictive factor of this unequal SDI.
Comparing Venous Thromboembolism Prophylactic Agents After Hip Fracture Surgery: A National Database Study
Authors: Joo Peter Y. , Modrak Maxwell , Park Nancy , Brand Jordan , Rubin Lee E. , Grauer Jonathan N. , Bernstein Jenna A.
Published: February 2023

Introduction:

Although the use of venous thromboembolism (VTE) chemoprophylaxis has markedly reduced VTE rates after hip fracture surgery, few studies have directly compared the efficacy of different anticoagulant agents in this setting. The purpose of this study was to compare outcomes of Lovenox, Eliquis, or Coumadin as VTE prophylaxis after hip fracture surgery.

Methods:

The PearlDiver MHip national database was queried for patients older than 60 years undergoing first-time hip fracture surgery with no concurrent pelvic or distal femoral fractures. Prescriptions for Lovenox, Eliquis, or Coumadin were identified. Univariate and multivariate analyses of patient characteristics, 90-day incidences of VTE, adverse events, and readmissions were compared. Odds ratios (ORs) were calculated, and significance was set at P < 0.01 based on Bonferroni adjustment.

Results:

A total of 11,384 patients were identified, with the Lovenox used for 6835 patients (60.0%), Eliquis for 1092 patients (9.6%), and Coumadin for 3457 patients (30.4%). The prevalence of 90-day VTE in the Lovenox, Eliquis, and Coumadin groups was 3.1%, 3.8%, and 5.0%, respectively (P < 0.001). Multivariate analyses adjusting for demographic and comorbidity profiles were conducted with Lovenox as the referent. Those on Eliquis had significantly lower transfusions (OR 0.52, P = 0.005), but similar rates of other outcomes including VTE (P > 0.01). Conversely, patients on Coumadin had significantly greater odds of any adverse event (OR 1.18, P < 0.001) and VTE (OR 1.58, P < 0.001).

Discussion:

In evaluating Lovenox, Eliquis, and Coumadin as VTE chemoprophylactic agents after hip fracture surgery in anticoagulant-naïve patients, Lovenox and Eliquis had similar 90-day VTE, whereas patients on Coumadin had greater odds of 90-day VTE. Interestingly, patients on Eliquis had nearly two-fold lower odds of transfusions compared with patients on Lovenox. Although consensus on the optimal VTE prophylactic agent after hip fracture surgery does not exist, Eliquis and Lovenox may be comparable options and seem to be more effective than Coumadin.
Technical Considerations and Avoiding Complications in Total Hip Arthroplasty
Authors: Krumme John W. , Bonanni Sean , Patel Nirav K. , Golladay Gregory J.
Published: February 2023

Total hip arthroplasty (THA) is considered to be the surgical procedure of the 20th century. Current projections show that by 2030, primary THA is expected to grow by 171%, with revision THA expected to increase by 142% in the same time frame. Although complications are not common, when they occur, they can cause notable morbidity to the patient. Understanding the unique anatomy and needs of each patient will prepare the surgeon to avoid soft-tissue or bony injury, optimize prosthesis placement, and decrease the risk of infection. This article aims to highlight common causes of early revision THA and provide specific technical strategies to avoid these complications. Following a systematic approach to the primary THA and using these techniques will assist the surgeon in avoiding complications to revision hip arthroplasty.
Prevalence of Impaired Glucose Tolerance/Prediabetes in Local Adult Obese Population Presenting to A Tertiary Care Hospital
Authors: Khan Hadi Niktash , Salman Aamir Muhammad , Ghaffar Tahir , Khan Sulaiman , Islam Siraj ul , Khan Shafiullah , . Nizamuddin , Ali Muhammad
Published: February 2023

Obesity is affecting all countries across the globe and becoming an epidemic. It is a major factor contributing to metabolic disorders, diabetes and cardiovascular diseases (CVD). In Pakistan, CVD has highest mortalities which is closely related to obesity and diabetes. Objective: To determine the frequency of impaired glucose tolerance (IGT) in local adult obese population. A cross sectional, descriptive study was designed department of Medicine, Hayatabad Medical Complex, Peshawar. Methods: A total of 136 patients with BMI of more than 25kg/m2 in Medical OPD with age between 18-60 years were included. Weight and height were measured for obesity and BMI calculation. All patients were subjected to 75gm oral glucose tolerance test after 08 hours overnight fast. Venous blood was withdrawn before and after the oral glucose solution and IGT were considered positive if the blood glucose level is between 140- 199mg/dl at 2-hour post oral glucose solution. Results: 136 patients were analyzed in which 42(31%) patients were having age between 18-40 years, 94(69%) patients were having age between 41-60 years. Mean age was 53 years with SD ± 10.44. Forty-nine (36%) patients were male and 87(64%) patients were female. Moreover 24(20%) patients had IGT while 112(80%) patients had normal glucose tolerance. Conclusion: Impaired glucose tolerance was found in 20% of adult obese population. The exponential rise from obesity 1 patients having 8% and obesity 3 patients having 57% IGT shows significantly increased risk.
Comparative study of Retrograde Intrarenal Surgery and Mini-Percutaneous Nephrolithotomy among Renal Stone Patients
Authors: Maqsood Zahid Muhammad , Farook Khalid , Ahmad Khaleel , Ali Liaquat , Muhammad Javed Hafiz , Mehmood Ul Hassan Syed
Published: February 2023

Mini-Percutaneous Nephrolithotomy (Mini-PCNL) and Retrograde intra-renal surgery (RIRS), can be carried out in a single stage or numerous phases depending on the burden, size, and/or location of the stone. Objective: To check the efficacy of Mini-Percutaneous Nephrolithotomy and Retrograde intra-renal surgery on adult patients with a renal stones. Methods: A total of 101 patients were included who underwent RIRS (n=51) or mini-PCNL (n=50) at Doctors Hospital Jail Chowk in Gujrat, Pakistan in 2021. Retrospective observations were made on 101 individuals who received RIRS or mini-PCNL. Results: The mean hospital stay time was significantly lower in RIRS group i.e., 01.81 ± 0.59 days as compared to mini-PCNL group (p value <0.001). The operation time was 63.72 ± 14.94 minutes for mini-PCNL and 72.65 ± 15.83 minutes for RIRS group. The stone clearance rate was 92% in mini-PCNL group and 82.35% in RIRS group. Conclusions: In conclusion, we found that both mini-PCNL and RIRS are safe and effective ways to treat renal calculi. RIRS is a non-invasive, practical therapeutic option with reduced hospitalizations times, morbidity, and complication rates for these individuals.
Awareness and Attitudes of Secondary School Students about Physiology Discipline in Southwest Region, Nigeria
Authors: Faborode Oluwaseun Samuel , Yusuf Issa Olakunle , Adeyemi Damilare Hakeem , Odewole Olaolu Joseph , Ajisafe Joy Adebowale , Dare Ayobami , Olaniyan Olugbemi Temitope , Onasanwo Samuel Adetunji
Published: February 2023

Physiology remains one of the core disciplines on which all biological and medical sciences were founded. In Nigeria, it is known that most students study Physiology at the undergraduate level by chance and not by choice and end up performing poorly, which could be mainly due to low awareness and knowledge of the discipline, its opportunities, and prospects. Therefore, this study investigated the awareness, attitude, and knowledge about physiology among senior secondary school students in Southwest Nigeria. A cross-sectional of 544 students in science-based senior secondary schools in south-west Nigeria were sampled. Our results showed a high level of awareness, with television being the dominant medium of information. However, knowledge of Physiology was low, while most of the students also showed interest in knowing more about it. Although gender does not seem to influence the level of knowledge, females had a better attitude towards learning about physiology. Similarly, residence did not affect attitude, howbeit associated with the level of knowledge. In conclusion, the high awareness and low knowledge observed in this study would give insights to educate students at the early stages of education about the opportunity and prospects of Physiology and other science-related disciplines.
Comparative influence of kolaviron and coenzyme Q10 on complex I activity, glutamate clearance, 3,4-dihydroxyphenethylamine metabolism, and redox stress in rotenone-induced neurotoxicity
Authors: Akinmoladun A. C. , Saliu Ibrahim , Abilogun Olaoluwa , Ajibola Omotola Helen , Amoo Zainab Abiola , Ojo Olubukola Benedicta , Farombi Ebenezer O. , Olaleye Mary Tolulope
Published: February 2023

3,4-dihydroxyphenethylamine (dopamine) depletion, inhibition of complex I activity, oxidative stress, and glutamate excitotoxicity are cardinal biochemical features of neurotoxicity induced by systemic unilateral infusion of rotenone. Kolaviron (KV), a biflavonoid from Garcinia kola seeds, has been proven to have pharmacological effects against neurotoxicity. Coenzyme Q10 plays an essential role in mitochondrial oxidative phosphorylation and as an antioxidant. This study examined the comparative influence of kolaviron and coenzyme Q10 on complex I activity, dopamine metabolism, glutamate clearance, and redox stress in rotenone-induced neurotoxicity in the cortex, hippocampus, and striatum of the brain of rats. Adult Male Wistar rats were pretreated with 200 mg/kg KV or 100 mg/kg coenzyme Q10 for 7 days followed by administration of a progressive six doses of 1.5 mg/kg rotenone within the next 48 h after which the animals were euthanized and the brain excised. On the cortical, hippocampal, and striatal regions of the brain, complex I activity, dopamine metabolism, oxidative stress markers, as well as glutamate metabolism were carried out and analyzed. In all brain regions examined, KV and coenzyme Q10 pretreatment modulated complex I activity, ameliorated redox imbalance, and enhanced dopamine metabolism via increasing the activity of tyrosine hydroxylase and decreasing monoamine oxidase activity. KV facilitated glutamate clearance through augmentation of glutamate dehydrogenase and glutamine synthetase activities.  The activity of KV was comparable to that of the mitochondrial membrane antioxidant compound, coenzyme Q10, this indicates that KV is a promising therapeutic agent in the treatment of Parkinson’s disease and its activity compares well with coenzyme Q10
Cement Dust Exposure Alters Secretory Functions, Biochemical Profile and Morphology of Gastrointestinal Tissues in Rats Exposed to Cement Dust
Authors: Owonikoko Mathew Wasiu , Salami Adeola Temitope , Odukanmi Olugbenga Adeola , Emikpe Benjamin O , Olaleye Samuel Babafemi
Published: February 2023

Asides direct gastrointestinal exposure, inhalation route is another major xenobiotic exposure pathway to the gastrointestinal tract via mucociliary escalator. This triphasic study assesses cement dust inhalatory exposure effect on the possible alterations of the gastrointestinal tissues and secretion. 72 male, sixteen (16) weeks old Wistar rats were randomized into 3 different phases of 24 animals. Each phase comprised of 3 group of 8 animals. Group 1 (control) were sham-operated with clean ambient air, group 2 (14-days exposed) were exposed to cement dust for 14days, and group 3 (28-day exposed) were exposed to cement dust for 28 days. Biochemical indices including superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), sulfhydryl group, carbonyl group, Na+-K+ATPase pump activity, Nitric oxide (NO) were investigated spectrophotometrically in gastric and hepatic tissues while histopathology was studied using standard procedure. There was significant increase in the level of MDA, NO and carbonyl- an observation that contrasts with the level of CAT, SOD and sulfhydryl; no significant difference in Na+-K+-ATPase pump was observed in the exposed groups compared with control. Histopathological alterations in salivary gland and gastric tissues includes edema, inflammatory cell infiltration and vascular congestion. There was significant alteration in basal salivary, gastric and biliary secretions; increased stimulated salivary and gastric secretion via cholinergic stimulation. Conclusively, histopathological and spectrophotometric analyses reflect that inhalatory experimental exposure to cement dust significantly alter gastrointestinal secretions and predisposes the gastrointestinal tract to an array of deleterious effects via protein oxidation and antioxidant depletion and tissue peroxidation.
Antihyperlipidemic property of Murraya koenigii ethanolic leaf extract on lipid profile of rats fed with cholesterol-enriched diets
Authors: Nwaji Azubuike Raphael
Published: February 2023

This study was designed to investigate the effect of orally administered ethanolic leaf extract of Murraya koenigii on lipid profile of rats fed with cholesterol-enriched diets for 14 days. The study was carried out on 20 male wistar rats divided into 4 groups (n=5). All animals were given ad libitum access to drinking water. Group A was the control group and received normal rat chow, group B received cholesterol-enriched diet (CED); while group C and D received cholesterol-enriched diet and were treated with 200mg and 400mg/kg body weight of ethanolic extract of Murraya koenigii leaf respectively. Blood samples were collected by cardiac puncture on the last day of the experiment for biochemical analysis. Lipid profile was determined by Colorimetric method. Data were expressed as mean ± SEM. Differences in means were compared using ANOVA and Students T-test, P-values ≤ 0.05 were taken as statistically significant. Results showed a significant increase (p ≤ 0.05) in Total cholesterol (TC) level (117.4 ± 4.6) and low density lipoprotein cholesterol (LDL-c) level (50.1 ± 4.7) of group B rats when compared to other groups. The MK (400 mg/kg) treated rats, showed a significant reduction in TC and LDL-c levels, and a significant increase in HDL-c level when compared to CED group. However, there were no significant changes in all the lipid parameters of the treated groups when compared to the control. This study shows that cholesterol-enriched diet causes dyslipidemia and Murraya koenigii exhibited significant hypolipidemic effect on serum TC and LDL-c and increases HDL-c. Hence, Murraya koenigii exhibit antihyperlipidemic properties. Keywords: Murraya Koenigii, hyperlipidemia, Lipid profile, Cholesterol-enriched diet
Determination of the Relationship Between C-Reactive Protein (CRP) Levels and Hepatitis B Surface Antigen
Authors: Gidado Maryam Buhari , Haroun Ali Ahmed , Magaji Yakubu , Abdullahi Zaharaddeen , Sani Abdulsalami Muhammad
Published: February 2023

The relationship between hepatitis B virus (HBV) infection and C-reactive protein (CRP), which is an inflammatory biomarker, is limited in studies on the general population. Thus, this study aimed at determining the relationship between CRP levels and Hepatitis B surface antigen in patients with hepatitis B. A total of 70 samples were screened for the presence of hepatitis surface antigen by one step hepatitis B Surface antigen test strip (serum/plasma) package insert. The samples were further subjected to ELISA test and quantitative real time PCR to determine the viral load. The performance of the assay on the 70 samples showed 17 (24.29%) patients were positive and 53 (75.71%) patients were negative for serological test. Out of the 17 samples which were positive for HBV, CRP was positive in 5 patients while 12 patients were negative for CRP. While out of 53 patients who were negative for HBV, 9 were positive for CRP and 44 were negative for CRP. For the significance of viral load for clinical monitoring, three titer groups were presented. Among the 70 samples tested for viral load of HBV, 50% (35/70) of samples showed low titer by the Ct˂30, while only 15.71% (11/70) of samples were detected with high viral load by Ct˃30. Statistical analysis showed insignificant relationship between CRP and HBV. Positive predictive value of CRP was lower;it is revealed that the presence of HBV infection cannot be predicted on the basis of CRP analysis only. The reason behind lower CRP concentration in HBV positive cases remains unclear but there is a perception that high CRP levels in the blood can be a marker of inflammation.
PENGARUH STRATEGI PEMBELAJARAN HYPNO QUANTUM TEACHING TERHADAP MOTIVASI BELAJAR TARUNA POLTEKPEL SURABAYA
Authors: H Sri Mulyanto , Suparman Jaja , Rumambi C
Published: February 2023

Peran dosen dalam membangkitkan motivasi belajar taruna sangat diperlukan danmenjadi kunci penting berhasilnya proses belajar mengajar di kelas. Oleh karena itudiperlukan strategi pembelajaran yang dapat menjadikan taruna lebih aktif, kreatif danmerangsang munculnya life skills, serta menciptakan suasana belajar yang menye­ nangkan (joyfull learning). Peneliti mempunyai ketertarikan untuk memadukan unsur hypnosis dan metode quantum teaching dalam proses pembelajaran sehingga menjadisuatu formula metode baru hypno quantum teaching. Bila dengan quantum teaching, proses belajar mengajar dapat berlangsung dengan menyenangkan ijoyfuli learning) maka dengan hypnosis diharapkan ada modifikasi perilaku sehingga terbentuk perilakubaru yang sesuai dengan harapan dosen. 

Metode dalam penelitian ini menggunakan metode eksperimen yang didesain untukdapat mengendalikan secara ketat variabel-variabel ekstra yang tidak berhubungan dengan variabel yang sedang diamati. Adapun sampel dalam penelitian ini adalah tarunaPoltekpel Surabaya dengan menggunakan teknik analisis quota sampling dan teknik analisis data dengan menggunakan model aplikasi statistik SPSS versi 21. 0 yaitu dengananalisis paired samples Tnest. Hasil dari penelitian ini menunjukkan bahwa perlakuan dalam eksperimen dapatmeningkatkan kemampuan belajar subyek. Dengan meningkatnya kemampuan belajarsubyek mengindikasikan bahwa motivasi belajar subyek meningkat. Hipotesis diterimadengan didasarkan pada basil t = 2, 17 5 dengan signifikansi 0,045 yang berarti signifikan.Hasil ini menunjukkan bahwa ada pengaruh penggunaan metode hypno quantumteachingterhadap motivasi belajar mahasiswa. Penggunaan strategi pembelajaran hypnoquantum teaching cukup efektif dalam meningkatkan motivasi belajar, khususnyapenerapannya kepada taruna.
ANALISA PENERAPAN SISTEM MANAJEMEN KESELAMATAN DAN KESEHATAN KERJA DI POLITEKNIK PELAYARAN SURABAYA
Authors: Haryanto Dwi , Simanjuntak Marihot , Wiratno Daviq
Published: February 2023

Sebagai  salah satu institusi yang  bergerak dibidang pelayanan jasa  pendidikan dan pelatihan di bidang pelayaran  Politeknik  Pelayaran Surabaya (Poltekpel) Surabaya dalam menjalankan tugas pokok dan fungsinya selalu memperhatikan faktor keselamatan di   lingkungan kerjanya. Sistern Manajemen Keselamatan dan Kesehatan Kerja (SMK3) merupakan suatu sistem pengaturan kebijakan-kebijakan  institusi yang berfungsi sebagai  pengontrol bagi pelaksanaan kebijakan K3 yang  diterapkan oleh institusi.  Lima  prinsip  penerapan SMK3  tersebut terns  dilakukan perbaikan berkelanjutan oleh manajemen Poltekpel Surabaya. Perbaikan berkelanjutan dilakukan agar kesinarnbungan penerapan SMK3  dapat ditingkatkan  sehingga  mengurangi   angka kecelakan kerja atau  rnendapatkan zero accident. SMK3  yang  diterapkan diberlakukan untuk  semua karyawan, pegawai, instruktur, dosen dan peserta diklat  secara  terntegrasi antara  mesin,  manuasia, material dan lingkungan, sehingga mcnghasilkan penghargaan zero accident atau nol kecelakaan. Penilaian resiko bahaya kerja dengan HIRA,  poteusi bahaya kerja yang teridentifikasi yaitu dengan  kategori dominan  high risk atau M menunjukkan bahwa  program SMK3 dilingkungan kerja Politeknik Pelayaran Surabaya perlu diterapkan agar  dapat  mengantisipasi  potensi bahaya yang  akan  terjadi dan zero accident lebih ditingkatkan
IMPLEMENTASI PERJANJIAN KERJA LAUT DI PT. DHARMA LAUTAN UTAMA SURABAYA
Authors: Parerungan Semuel D
Published: February 2023

Dalam sistem hukum Indonesia yang dimaksudkan dengan hukum ketenagakerjaan atau hukum perburuhan adalah suatu peraturan hukum yang mengatur hubungan kerja antara tenaga kerja dan majikan, yang mengakibatkan seseorang secara pribadi ditempatkan di bawah pimpinan orang lain. Tentunya hubungan kerja ini hanyalah suatu hubungan antara tenaga kerja dengan majikannya, hubungan kerja demikian hanya menunjukkan adanya suatu kedudukanyang menggambarkan hak dan kewajiban tenaga kerja terhadap majikan, demikian juga hak dan kewajiban majikan terhadap tenaga kerja. Penelitian ini merupakan penelitian normatifempiris yang pada dasarnya merupakan penggabungan antara pendekatan hukum normatif dengan adanya penambahan berbagai unsur empiris dengan mendayagunakan data dan bahan lapangan yang secara sosiologis dapat membantu menjelaskan implementasi perjanjian kerja laut dalam studi kasus di PT. Dharma Lautan Utama. Diantara hukum positif yang diteliti adalah ketentuan yang telah diatur dalam pasal-pasal KUHD pasal: 402, 409, 415, 416, 436, 437, 438, 452, pasal 1602 KUH Perdata, dan PP No. 7 tahun 2000 tentang Kepelautan. Hasil penelitian ini didapatkan bahwa implementasi perjanjian kerja laut dalam studi kasus di PT. Dharma Lautan Utama terimplementasi dengan baik yang artinya pemenuhan hak dan kewajiban masing-masing pihak terlaksana dengan baik, hanya masih perlu perbaikan dalam format perjanjian kerja laut agar lebih transaparan dan akuntabel, yang mana akhirnya dari masing-masing pihak dapat lebih jelas dalam pemenuhan hak dan kewajibannya
ANALISIS TERLAMBATNYA PEMBONGKARAN CRUDE PALM OIL DI MT. AU VIRGO
Authors: Prasetyawan Andi , Rohman M. Aziz
Published: February 2023

Pengangkutan barang dari pelabuhan muat ke pelabuhan bongkar bisa tepat waktu sesuai dengan jadwal yang telah diperkirakan, maka persiapan dan penanganan muatan harus diperhatikan agar tidak terjadi keterlambatan muatan crude palm oil. Yang perlu diperhatikan agar tidak mengalami keterlambatan pembongkaran muatan crude palm oil dengan cara menghindari dan meminimalisir faktor-faktor yang menyebabkan keterlambatan pembongkaran crude palm oil. Berdasarkan pengalaman selama praktek berlavar di MT Au Virgo banyak terjadi kendala pada pembongkaran muatan crude palm oil di MT Au Virgo yang menyebabkan terlambatnya kegiatan bongkar muat yang diakibatkan oleh boiler sebagai alat pemanas muatan, sehingga penulis tertarik mengadakan penelitian analisis faktor-faktor penyebab keterlambatan pembongkaran muatan crude palm oil yaitu dengan metode fishbone analysis dan Fault tree analysis sebagai strategi pemecahan masalah. Saran yang harus dilakukan agar tidak terjadi keterlambatan pembongkaran muatan crude palm oil dengan cara menjaga temperature dengan baik agar rnuatan tidak mudah membeku.
PELAKSANAAN DINAS JAGA PADA SAAT OPERASI BONGKAR MUATAN DI KAPAL MT. TRANSKO ARAFURA PADA PELABUHAN GUNUNG SITOLI
Authors: Widyaningsih Upik , Nisa’ Lestari Jumrotin
Published: February 2023

Penelitian ini bersifat deskriptif-kualitatif yang mendeskripsikan tentang pelaksanaan dinas jaga pada saat operasi bongkar muatan di pelabuhan yang bertujuan untuk mengetahui pelaksanaan dinas jaga di pelabuhan bagi crew deck kapal. Tempat dilaksanakannya penelitian ini di atas kapal MT. Transko Arafura. Pengumpulan data dalam penelitian ini dilakukan dengan cara observasi lapangan, dokumentasi dan wawancara. Dari hasil observasi dan wawancara didapatkan bahwa masih terdapat perwira jaga maupun juru mudi jaga yang tidak melaksanakan jaga sesuai dengan prosedur dan dengan sistem yang baru yaitu auto perwira dan juru mudi jaga masih awam dan perlu familiarisasi. Kesimpulan dalam penelitian ini yaitu pelaksanaan dinas jaga pada saat operasi bongkar muatan belum optimal, perwira dan juru mudi jaga belum memahami dan mengerti tentang pentingnya melaksanakan peraturan-peraturan mengenai dinas jaga sesuai prosedur di pelabuhan. Penulis menemukan kurangnya kedisiplinan dan kurangnya ketelitian perwira dan juru mudi jaga dalam melaksanakan dinas jaga di pelabuhan pada saat kapal operasi bongkar muatan.
Diagnosis dan Tata Laksana Nefritis Lupus
Authors: Giani Maia Thalia , Septian Muhammad Raditia
Published: February 2023

Nefritis lupus merupakan salah satu manifestasi lupus eritematosus sistemik dengan morbiditas dan mortalitas tinggi. Penegakan diagnosis menjadi salah satu tantangan dalam praktik kedokteran sehari-hari. Tata laksana dini dapat memperbaiki kelangsungan serta kualitas hidup pasien.

 

Lupus nephritis is one of manifestations of systemic lupus erythematosus with high morbidity and mortality. Diagnosis of lupus nephritis may be challenging in daily medical practice. Early initiation of treatment can improve patient survival and quality of life.
Monkeypox: Manifestasi dan Diagnosis
Authors: Kuncoro Cynthia Sandra
Published: February 2023

Cacar monyet merupakan penyakit zoonosis yang disebabkan oleh virus monkeypox. Kasus cacar monyet meningkat beberapa tahun terakhir ini, bahkan dapat ditemukan di negara non-endemis dengan prevalensi terbanyak pada usia dewasa. Transmisi terjadi dari hewan ke manusia ataupun manusia ke manusia; kuman masuk melalui nasofaring, orofaring, ataupun jaringan kulit. Manifestasi klinis khas berupa limfadenopati dan penyebaran lesi kulit monomorfik secara sentrifugal dari mulut hingga seluruh tubuh. Masa penularan terjadi pada fase prodromal hingga seluruh krusta kulit terkelupas. Konfirmasi diagnosis melalui pemeriksaan PCR. Tata laksana umumnya simtomatik dan isolasi penderita. Vaksinasi cacar diketahui dapat meringankan gejala dan mengurangi komplikasi. Penyakit ini bersifat swasirna, tetapi berisiko menimbulkan komplikasi.

 

Monkeypox is a zoonotic disease, caused by monkeypox virus. Monkeypox cases have increased even in non-endemic countries; mostly in adults. Transmission occurs from animal to human and human to human; infection is through nasopharynx, oropharynx, and skin. Its typical manifestations are lymphadenopathy and monomorphic skin lesions spread centrifugally from the mouth to all over the bodies. A person is considered to be contagious from prodromal phase until all the scabs have fallen off. Diagnosis could be confirmed by PCR test. Management includes symptomatic and isolation. Smallpox vaccination is reported to reduce the severity and incidence of complications. It is a self-limiting disease, but there is a still risk of complication.
A Panel Discussion in Nutritional Management in Cancer Care
Authors:   Tata Memorial Hospital (HBNI), Mumbai, India, Timmanpyati Shivshankar , Reddy B Ravinder , Premalatha Sunitha , Rajeswari A , Suryanaryana Prasanthi , Naidu Sai Sankalp , Samant Bhakti​
Published: February 2023

Nutritional status plays an important role in cancer treatment. Several studies have strongly indicated that malnutrition has a negative impact on the efficacy of cancer treatment. Nutritional negligence or poor nutrition may impede the progress in cancer care, rendering them a harder time with the toxic side effects. It is well documented that there is a high prevalence of cancer-related malnutrition ranging from 25% to 70% from various studies, and cancer patients are the most malnourished of all other patient groups. Escalation of nutrients, effective counseling, and consistent monitoring as an adjuvant to cancer treatment, not only improve nutrition parameters, and body composition but also help in managing toxic effects, thus enhancing the quality of life and ultimately better survival. Keywords: Cancer nutrition, Onconutrition, Malnutrition
Nutrition in GI Cancer : A Review
Authors:   Surgical Gastroenterology, AIIMS, Mangalagiri, Andhra Pradesh, 522503, India, Gupta Shahana , Ghosh Saurav Kumar
Published: February 2023

Nutrition in gastrointestinal (GI) cancer is an important part of treatment protocol. A detailed study of published guidelines is necessary to prevent pre-operative malnutrition and sustain peri-operative nutrition in such patients. In this review, we discuss and propose guidelines and recommendations based on established guidelines to suit the Indian population with different GI cancers (gastric, esophageal, pancreatic, colorectal and hepatocellular cancers). Keywords: GI cancer, Nutrition, Enteral nutrition, Parenteral nutrition, Immunonutrition
The Impact of FinTech Merge Operation on Financial Performance: Evidence from a Banking International Sample
Authors: Bussoli Candida , Conte Danilo , Barone Marco
Published: February 2023

The FinTech phenomenon has recently had a significant impact on the financial sector, opening up new potential for cost-saving measures and providing increasingly sophisticated financial services. On the other hand, FinTech has helped new players—typically technology companies—enter the financial sector and financial intermediation. Financial institutions have started cooperative and merging operations. As a result, to incorporate the new technology created in the market into their business model. This study aims to determine whether banks engaged in a FinTech merger experience improved financial performance. The research hypothesis is tested using an international sample composed of 106 financial intermediaries that implemented FinTech mergers from 2010 to 2018. The methodology employed is the Propensity-Score-Matching (PSM) technique which provides empirical results using a control group of 8,886 financial firms, with a total of 79,974 observations. The results demonstrate how a FinTech merger enhances intermediaries' financial performance. This evidence highlights the strategic value of FinTech fusion in the modern financial system. This study offers important insights for future research on the topic, as it contributes to combining two distinct outfits of literature, FinTech and M&A, into one that has been little addressed in the financial sector.
Intercultural Communication and Identity --- How Do They Affect Second Language Teaching?
Authors: Jin Meng-yue
Published: February 2023

Due to imperative needs of English studying, such as globalization, internationalization, advances in transportation and communication technologies, ethics and personal growth and responsibility, etc, it is rather important for people with these needs to know about intercultural communication as well as identity. The aim of knowing intercultural communication is to reduce the impediments within communication to achieve a smooth conversation. Similar to intercultural communication, identity is also difficult to define because it is multi-layered and multifaced. The teaching of second language involves more knowledge about culture and the identity of the other speaker. To improve the communication, a method is presented, including explanation, collection, implementation and feedback. The ultimate goal is to motivate learners and practice their linguistic and intercultural skills.
Strategi Komunikasi Kepemimpinan : Suatu Tinjauan Teoritis
Authors: Thareeq Akbar Perkasa  , Rafinita Aditia
Published: February 2023

Memilih strategi komunikasi merupakan langkah penting yang memerlukan pendekatan yang cermat dalam perencanaannya, karena jika strategi yang dipilih salah maka hasil yang diperoleh bisa berakibat fatal terutama kerugian uang, waktu, materi dan tenaga. Dalam sebuat strategi, ada empat langkah penting yang perlu dilaksanakan diantaranya yakni perencanaan (planning), pengorganisasian (organizing), pelaksanaan (actuiting), dan pengawasan/evaluasi (controlling). Penulisan artikel ini bertujuan untuk memberikan dasar teoritis tentang strategi komunikasi kepemimpinan dan dapat membantu para pemimpinan untuk bisa menerapkan strategi komunikasi kepemimpinan dalam melaksanakan tugas dan kewajiban sebagai seorang pemimpin. Hasil penelitian menunjukkan bahwa strategi komunikasi kepemimpinan bertujuan untuk mengamankan pemahaman, menetapkan penerimaan serta memotivasikan tindakan. Seorang pemimpin harus mempunyai strategi yang baik dalam melaksanakan tugas serta memikul tanggung jawab yang dibebankan dalam rangka mempertahankan eksistensi serta perkembangan suatu perusahaan maupun organisasi yang dipimpinnya. Hal ini menunjukkan bahwa strategi komunikasi kepemimpinan yang baik akan menghasilkan sebuah kepemimpinan yang berhasil.
Standardized extract of Sanguisorba minor attenuates injury in aging rat model via the Nrf2/HO‑1 pathway
Authors: Mirzavi Farshad , Rajabian Arezoo , Boroumand‑Noughabi Samaneh , Hosseini Azar , Boroushaki Mohammad Taher , Hassanzadeh Sonita
Published: February 2023

Aging promotes damage to vulnerable organs like brain and liver. Sanguisorba minor has been traditionally used to cure various ailments. Few studies have reported pharmacological activities of this medicinal plant. This research aimed to investigate the effects of Sanguisorba minor extract (SME) on brain and liver injury in aging rats and identify the underlying mechanisms. The aging model was developed by subcutaneously injecting D‑galactose and simultaneously treating them with SME. After biochemical and pathological assessments, mRNA expression levels of nuclear factor‑erythroid factor 2‑related factor 2 (Nrf2) and Nrf2‑ regulated gene, heme oxygenase‑1 (HO‑1), in the brain and liver tissues were determined. As a result, malondialdehyde and acetylcholinesterase levels were elevated while total thiol content and superoxide dismutase were reduced in the aging rats. Treatment with the extract remarkably attenuated oxidative injury and pathological changes in liver and brain tissues. Concomitantly, the extract up‑regulated Nrf2 and HO‑1 genes. Our findings exhibited SME may improve the aging‑related brain and liver damage through the Nrf2‑HO‑1 pathway.