bluuebunny/crossref_metadata_2025 huggingface dataset:
Prenatal Diagnosis of Shone’s Syndrome by Fetal Echocardiography
Authors: Li Zhuoyan , Wu Yurong , Chen Sun
Published: April 2020

Background：Shone’s syndrome is a rare complex with few data published on its prenatal diagnosis, this study aimed to compare the fetal echocardiographic features between Shone’s syndrome fetuses and coarctation of the aorta (CoA) fetuses to improve the prenatal diagnosis of Shone’s syndrome and identify the mitral valve obstruction associated with the anomaly. Methods: Retrospective study was performed. Between January 2015 to December 2019, fourteen fetuses diagnosed with Shone’s syndrome were enrolled and ten were analyzed in our final study, their clinical information and echocardiographic features were compared to normal controls (N=30) and CoA cases (N=10). The main points of identification were summarized. Results: Comparing to normal controls, the PA/AO ratio was increased in both Shone’s syndrome and CoA, but Shone’s syndrome fetuses had higher PA/AO ratio than CoA fetuses (P=0.006). RV/LV and TVC/MVC ratios were only elevated in Shone’s syndrome cases (P<0.0001, P<0.0001). Analysis revealed that the TVC/MVC ratio had the best capability in predicting Shone’s syndrome and fetuses with TVC/MVC ratio over 1.290 were more likely to have Shone’s syndrome rather than CoA. Meanwhile, the main points of identification in mitral valve obstruction included (1) restrictive opening of the mitral valve, thickened leaflets, echo-enhancement of chordae tendineae and single papillary muscle in short-axis section view; (2) decreased antegrade flow and abnormal flow pattern of mitral valve in color Doppler image. Chi-square test revealed that restrictive opening of the mitral valve and single papillary muscle were the most relevant features of mitral valve obstruction. Conclusions: There are several parameters of prenatal diagnosis of Shone’s syndrome by fetal echocardiography, including (1) echocardiographic measurements: elevated RV/LV ratio, PA/AO ratio and TVC/MVC ratio, of these, the TVC/MVC ratio has the best capability in predicting Shone’s syndrome; (2) morphologic changes in short-axis section view: restrictive opening of the mitral valve and single papillary muscle are the most relevant features of Shone’s syndrome.
Palace at Żyrowa. Transformations from the 15th to Early 20th Centuries
Authors: LEGENDZIEWICZ Andrzej , MARCINÓW Aleksandra
Published: April 2020

The paper presents the results of research carried out in the palace at Żyrowa. The introduction discusses the architecture of the palace, analyses source references to the site and identifies successive owners. The architectural research into technology, building material and architectural detail, as well as iconographic studies were the basis for the considerations. They gave grounds for the identification of the oldest building that dates back to the Gothic period and of the scope of the Mannerist expansion that was carried out in 1631–44 by Count Melchior Ferdinand de Gaschin. The scope of the Baroque and new-style transformations in the early 20th century is also discussed. The summary emphasizes the uniqueness of the layout which stands out from other Silesian residences in terms of size, programme and architecture.
Figure 2: Phylogeographic, morphometric and taxonomic re-evaluation of the river sardine, Mesobola brevianalis (Boulenger, 1908) (Teleostei, Cyprinidae, Chedrini)
Authors: Ridden Megan A , Bills Roger , Villet Martin H
Published: April 2020

The river sardine, Mesobola brevianalis (Boulenger, 1908), is the type species of Mesobola Howes, 1984.
Standard phylogenetic analyses of partial sequences of the cytochrome oxidase I
gene of individuals from populations across southern Africa that are currently
identified as M. brevianalis showed that
these populations represent four genetically distinct allopatric lineages.
Furthermore, Engraulicypris sardella (Günther, 1868), the type species of Engraulicypris Günther,
1894, was convincingly nested amongst these clades.

Fig 2. Truss network used for morphometric analysis, defined by
ten landmarks A–J.
The influence of riverbank filtration on regional water resources: a case study in the Second Songhua River catchment, China
Authors: Ye Xueyan , Cui Ruijuan , Wang Lixue , Du Xinqiang
Published: April 2020

Riverbank filtration (RBF) of river water recharging a groundwater system has been identified as a source of water supply that guarantees the quantity of abstracted water and reduces the cost of water treatment. This paper evaluates the safe yield of groundwater in suitable areas using a numerical model of groundwater flow and discusses the influence of RBF on the temporal variation of regional hydraulic heads, groundwater flow, river flow, and groundwater–surface water interaction (GSI) under different precipitation frequencies from 20% to 95% along the Second Songhua River in Northeast China. This study shows that the potential of RBF is enormous and that the total safe yield of groundwater abstraction was 29.56 × 104 m3/day under the precipitation frequency of 95%. The direction of regional groundwater flow was not obviously changed except within the local groundwater flow field under the maximum safe yield pumping conditions. When the precipitation frequencies are higher than 75%, the direction of the GSI might be changed, and the rate of river recharge of groundwater is enhanced. The water quantity that would be captured from the river does not threaten the safety of the river ecology. It is concluded that there were no obvious adverse impacts of the large scale of RBF on regional water resources in the Second Songhua River area.
1918 Grip Pandemisi Kıssasından COVID-19 Pandemisine Hisseler
Authors: TEMEL M. Kemal , ERTIN Hakan
Published: April 2020

Yirminci yüzyıl başından bu yana dünyada respiratuvar virüslerden kaynaklanan beş pandemi gerçekleşmiştir. Bunlardan ilk dördü grip (İnfluenza A) virüslerinden kaynaklanmışken halihazırda sürmekte olan COVID-19 pandemisi bir koronavirüs suşundan ileri gelmiştir. 1918 tarihli “İspanyol gribi” pandemisi dünya genelinde yaklaşık 500 milyon kişiyi kapsamış ve 40–100 milyon ölümle sonuçlanmış olup, bugün respiratuvar viral pandemiler için olabilecek “en kötü senaryo” kabul edilmektedir. Halihazırdaki COVID-19 pandemisi de Aralık 2019’dan bugüne (Nisan 2020), >1,2 milyon vaka ve >60 bin ölümle sürmektedir. Bu pandemide, virüsün türü (yeni ve pandemik bir SARSr-CoV suşu) ve konağın yaşı (>50–60 yaş) temelinde daha yüksek mortaliteli, yeni bir “koronavirüs hastalığı” gözlenmekte olup tıp (başta epidemiyoloji ve halk sağlığı) tarihinde yeni bir sayfa açılmıştır. Yanı sıra, 1918’de olduğu gibi yüz yıl sonra bugün de halen efektif bir anti(korona)viral tedavi bulunmamakta ve bu çaresizliğin klinik, sosyolojik, psikolojik ve makroekonomik sonuçları dünyada ve ilk resmi vakanın 11 Mart’ta kaydedildiği Türkiye’de şimdiden derinden hissedilmektedir. Ayrıca, yine 1918 pandemisinin mortalitenin giderek arttığı üç dalga halinde seyretmiş olduğu gibi, COVID-19 pandemisinde de gelecek haftalarda daha sarsıcı bir epizodun başlaması endişe edilen ihtimaller arasındadır. Bu yazıda katastrofik 1918 pandemisi esnasında yaşananlardan hareketle önümüzdeki COVID-19 sürecinde yaşanabilecek olanlara dair bir mukayese yapmak ve sonuçlar çıkarmak, önümüzdeki risklerin (başta virülansı ve dolayısıyla mortaliteyi artırabilecek bir viral mutasyon) ciddiyetini vurgulamak ve böylece T.C. Sağlık Bakanlığı başta olmak üzere pek çok ulusal ve küresel sağlık otoritesi tarafından çeşitli medya kanalları aracılığıyla yinelenmekte olan sosyal izolasyon çağrısını desteklemek amaçlanmıştır.
Indium Bromide-catalyzed Unprecedented Hydrogenolysis: A Novel One-Pot Synthesis of Per-O-Acetylated β-carboxymethyl O and S-glycosides
Authors: Yadav Ram Naresh , Singh Amrendra K , Banik Bimal
Published: April 2020

Numerous O (oxa)- and S (thia)-glycosyl esters and their analogous glycosyl
acids have been accomplished through stereoselective glycosylation of various peracetylated
bromo sugar with benzyl glycolate using InBr3 as a glycosyl promotor followed
by in situ hydrogenolysis of resulting glycosyl ester. A tandem glycosylating and hydrogenolytic
activity of InBr3 has been successfully investigated in a one-pot procedure. The
resulting synthetically valuable and virtually unexplored class of β-CMGL (glycosyl acids)
could serve as an excellent potential chiral auxiliary in the asymmetric synthesis of a
wide range of enantiomerically pure medicinally prevalent β-lactams and other bioactive
molecules of diverse medicinal interest.
Comprehensive Bioinformatics Analysis Identifies Tumor Microenvironment and Immune-related Genes in Small Cell Lung Cancer
Authors: Song Yongchun , Sun Yanqin , Sun Tuanhe , Tang Ruixiang
Published: April 2020

Background:

Tumor microenvironment (TME) cells play important roles in tumor
progression. Accumulating evidence show that they can be exploited to predict the
clinical outcomes and therapeutic responses of tumor. However, the role of immune
genes of TME in small cell lung cancer (SCLC) is currently unknown.

Objective:

To determine the role of immune genes in SCLC.

Methods:

We downloaded the expression profile and clinical follow-up data of SCLC
patients from Gene Expression Omnibus (GEO), and TME infiltration profile data of
158 patients using CIBERSORT. The correlation between TME phenotypes, genomic
features, and clinicopathological features of SCLC was examined. A gene signature
was constructed based on TME genes to further evaluate the relationship between
molecular subtypes of SCLC with the prognosis and clinical features.

Results:

We identified a group of genes that are highly associated with TME. Several
immune cells in TME cells were significantly correlated with SCLC prognosis
(p<0.0001). These immune cells displayed diverse immune patterns. Three molecular
subtypes of SCLC (TMEC1-3) were identified on the basis of enrichment of immune
cell components, and these subtypes showed dissimilar prognosis profiles (p=0.03).
The subtype with the best prognosis, TMEC3, was enriched with immune activation
factors such as oncogene M0, oncogene M2, T cells follicular helper, and T cells CD8
(p<0.001). The TMEC1 subtype with the worst prognosis was enriched with T cells
CD4 naive, B cells memory and Dendritic cells activated cells (p<0.001). Further
analysis showed that the TME was significantly enriched with immune checkpoint
genes, immune genes, and immune pathway genes (p<0.01). From the gene
expression data, we identified four TME-related genes, GZMB, HAVCR2, PRF1 and
TBX2, which were significantly associated with poor prognosis in both the training
set and the validation set (p<0.05). These genes may serve as markers for monitoring
tumor responses to immune checkpoint inhibitors.

Conclusion:

This study shows that TME features may serve as markers for evaluating
response of SCLC cells to immunotherapy.
Film-Forming Nanogels: Effects of Nanocarriers and Film-Forming Gel on the Sustained Release of Curcumin
Authors: Nguyen Khanh T. , Tran Phuong H.L. , Ngo Hai V. , Tran Thao T.D.
Published: April 2020

Background:

Although film-forming hydrogels possess the advantages of both film and hydrogel
dosage forms, certain limitations still remain.

Objective:

This study aims to investigate the use of film-forming hydrogels and the effects of nanocarriers on
the sustained release of a poorly water-soluble drug, curcumin.

Methods:

The film-forming hydrogels contained either zein or polyvinylpyrrolidone as a film former, in addition
to hydroxypropyl methylcellulose, oleic acid, ethanol and water. Curcumin was encapsulated in poly(lacticco-
glycolic acid) and gelatine nanoparticles using a sonoprecipitation method. Free drug and drug-loaded
nanoparticles were later dispersed into blank hydrogels to produce the film-forming nanogels.

Results:

The results suggested that the encapsulation of curcumin in nanoparticles could reduce the drug particle
size to less than 200nm for easier diffusion and could shield curcumin from chemical interactions that limit its
topical permeability. Curcumin was more compatible with gelatine nanoparticles than with poly(lactic-coglycolic
acid) nanoparticles, and gelatine nanoparticles, in turn, were more compatible with zein than with polyvinylpyrrolidone
film-forming nanogels. Therefore, gelatine nanoparticles in zein film-forming nanogels greatly
elevated the permeability of curcumin by over five times that afforded by gelatine nanoparticles in polyvinylpyrrolidone
film-forming nanogels.

Conclusion:

This research suggested that film-forming nanogel is a promising drug delivery system for both
improved permeability and sustained topical diffusion of the extremely hydrophobic drug curcumin depending
on the compatibility between the nanocarrier and the film-forming hydrogel.
Overview of Subsynchronous Oscillation in Grid-connected Wind Farm
Authors: Pei-Zhen Xu , Yong-Geng Lu , Xi-Min Cao
Published: April 2020

Background:

Over the past few years, the subsynchronous oscillation (SSO) caused by
the grid-connected wind farm had a bad influence on the stable operation of the system and has now
become a bottleneck factor restricting the efficient utilization of wind power. How to mitigate and
suppress the phenomenon of SSO of wind farms has become the focus of power system research.

Methods:

This paper first analyzes the SSO of different types of wind turbines, including squirrelcage
induction generator based wind turbine (SCIG-WT), permanent magnet synchronous generator-
based wind turbine (PMSG-WT), and doubly-fed induction generator based wind turbine
(DFIG-WT). Then, the mechanisms of different types of SSO are proposed with the aim to better
understand SSO in large-scale wind integrated power systems, and the main analytical methods
suitable for studying the SSO of wind farms are summarized.

Results:

On the basis of results, using additional damping control suppression methods to solve SSO
caused by the flexible power transmission devices and the wind turbine converter is recommended.

Conclusion:

The current development direction of the SSO of large-scale wind farm grid-connected
systems is summarized and the current challenges and recommendations for future research and development
are discussed.
Antivaccine Messages on Facebook: Preliminary Audit (Preprint)
Authors: Dhaliwal Dhamanpreet , Mannion Cynthia
Published: April 2020

BACKGROUND

The World Health Organization lists vaccine hesitancy as one of 10 threats to global health. The antivaccine movement uses Facebook to promote messages on the alleged dangers and consequences of vaccinating, leading to a reluctance to immunize against preventable communicable diseases.

OBJECTIVE

We would like to know more about the messages these websites are sharing via social media that can influence readers and consumers. What messages is the public receiving on Facebook about immunization? What content (news articles, testimonials, videos, scientific studies) is being promoted?

METHODS

We proposed using a social media audit tool and 3 categorical lists to capture information on websites and posts, respectively. The keywords “vaccine,” “vaccine truth,” and “anti-vax” were entered in the Facebook search bar. A Facebook page was examined if it had between 2500 and 150,000 likes. Data about beliefs, calls to action, and testimonials were recorded from posts and listed under the categories Myths, Truths, and Consequences. Website data were entered in a social media audit template.

RESULTS

Users’ posts reflected fear and vaccine hesitancy resulting from the alleged dangers of immunization featured on the website links. Vaccines were blamed for afflictions such as autism, cancer, and infertility. Mothers shared testimonies on alleged consequences their children suffered due to immunization, which have influenced other parents to not vaccinate their children. Users denied the current measles outbreaks in the United States to be true, retaliating against the government in protests for fabricating news.

CONCLUSIONS

Some Facebook messages encourage prevailing myths about the safety and consequences of vaccines and likely contribute to parents’ vaccine hesitancy. Deeply concerning is the mistrust social media has the potential to cast upon the relationship between health care providers and the public. A grasp of common misconceptions can help support health care provider practice.
Longevidade escolar em alunos de camadas populares
Authors: Oliveira Anandra Santos Ribeiro de , Nogueira Marlice de Oliveira e
Published: April 2020

Este artigo apresenta os resultados de uma revisão de estudos nacionais sobre os fatores explicativos associados à longevidade escolar de alunos de camadas populares no contexto brasileiro. Foram consultados, assim, artigos, dissertações e teses publicados no período de 1990 a 2014. Como resultado, percebeu-se que as pesquisas acerca do tema tendem a explicar a longevidade escolar em camadas populares a partir de oito categorias explicativas principais: (a) práticas familiares de escolarização; (b) mobilização individual; (c) capital social; (d) características socioeconômicas singulares; (e) influência escolar; (f) influência do professor; (g) disposições constituídas; e, (h) acontecimento de circunstâncias favoráveis: êxitos escolares parciais e eventos aleatórios.
«Soft power» as a catalysator of socio-political conflicts
Authors: Ivanov Oleg Borisovich
Published: April 2020

The article is devoted to the study of a set of technologies united by the term “soft power” from the standpoint of using the potential of these technologies in order to manage socio-political conflicts in target countries. The essence and purpose of “soft power” in the contemporary activities of international political actors is revealed and investigated, and practical experience is used to study the key tools of “soft power”, including as an instrument of influence and propaganda in the global information space. The author makes a reasoned attempt to prove that in the era of globalization the importance and influence of “soft power” increases compared to traditional “hard” tools of influence, that “soft power” is actively used as a theoretical and practical guide at the global geopolitical level. The positive and negative potential of “soft power” are critically evaluated, the basic methods of protection against its destructive influence are analyzed.
Belleza en el arte y en la naturaleza. La aparente discrepancia entre Hegel y Schelling
Authors: Bosch Magdalena
Published: April 2020

.
En torno a la existencia de una estética nietzscheana
Authors: Puelles Romero Luis
Published: April 2020

RESUMENEstas páginas, dedicadas al libro de Luis de Santiago Guervós "Arte y poder. Arpoximación a la estética de Nietzsche" (Madrid, Trotta, 2004), tratan de indagar en las condiciones de posibilidad que permiten postular la existencia de una estética nietzscheana. Para ello, además de comentar el libro que las origina, se observa en ellas las confrontación de la aportación nietzscheana sobre lo artístico con la tradición estética kantiana.PALABRAS CLAVENIETZSCHE-ESTÉTICA-ARTEABSTRACTThis pages, dedicated to the book of Luis de Santiago Guervós "Arte y poder. Arpoximación a la estética de Nietzsche" (Madrid, Trotta, 2004), try to investigate in the conditions of posibility that permit to postulate the existence of one nietzschean aesthetic. For that, furthermore of dicuss the book that is the origin of it, we remark here the confrontation between Nietzsche´s contribution to the artistic and kantian tradition aesthetic.KEYWORDSNIETZSCHE-AESTHETICS-ART
La crítica moral y religiosa en la obra de Cyrano de Bergerac
Authors: Gómez Rodríguez Carlos
Published: April 2020

RESUMENEl presente artículo examina el pensamiento de Savinien de Cyrano de Bergerac (1619 - 1655) tal y como se expresa en dos de sus obras fundamentales: L´autre Monde ou les états et empires de la lune (publicada en 1657, dos años después de su muerte) e Histoire comique des états et empires du Soleil (1662). En ellas expresa de forma mordaz y extremadamente crítica sus posiciones cosmológicas y filosóficas. Este componente polémico se extiende en Cyrano ya no sólo hacia una cosmología tradicionalmente aliada con el Cristianismo, sino al antropocentrismo cristiano y a importantísimos dogmas teológicos, como la cristología, la providencia o la inmortalidad del alma.PALABRAS CLAVEANTROPOCENTRISMO-PLURALIDAD DE MUNDOS-MATERIALISMO-INMORTALIDADABSTRACTThis paper examines Savinien de Cyrano de Bergerac (1619 - 1655) as they are expresed in his major Works: L´autre Monde ou les états et empires de la lune (published in 1657, two years after his death) and  Histoire comique des états et empires du Soleil (1662). In these books he expreses his ideas about cosmology and philosophy with extreme criticism. This polemics but to Christian antropocentrism and to very important theological dogma such as christology, providentialism or the soul´s inmortality.KEYWORDSANTROPOCENTRISM-PLURALITY OF WORLDS-MATERIALISM-INMORTALITY
Algunas precisiones sobre la argumentación a favor y en contra del aborto
Authors: Rubio Carracedo José
Published: April 2020

RESUMENLa valoración moral del aborto voluntario no sólo es un delicado y complejo problema bioetico, sino que se ha convertido en las últimas décadas en piedra de escándalo. Por eso me he decidido a abordar su estudio justamente para intentar poner un poco de orden, sosiego y claridad de ideas en el debate, con independiencia de la postura personal que presento, en todo caso avalada por razonamientos. De todos modos, es indudable que se presentan casos de difícil resolución, casos que se ofrecen incluso como dilemas, abiertos como tales al pluralismo moral. Las cuestiones legales y la necesaria despenalización se tratan al final.PALABRAS CLAVEABORTO, DESPENALIZACIÓN, AUTONOMÍA, PLURALISMO MORALABSTRACTThe Moral Appraisal of Voluntary Abortion is not only a sharp and complex bio-ethical problem, but also it has become in the last decades a scandal stone. For that reason I undertake his study with the main intention of set some order, tranquility and distinctness in discussion, independently of my own position, endorsed in any case by arguments. Anyway, it is beyond discussion that they happen to be cases of difficult resolution, even cases that offer themselves as dilemmas, open as such to moral pluralism. The legal questions and the required Out-Penality will be discussed at the end of the paper.KEYWORDSABORTION, OUT PENALITY, AUTONOMY, MORAL PLURALISM
Control vertical o vacío de sentido: relevancia del concepto de mundo para la definición de la ética política. La polémica de Strauss y Voegelin con Max Webe
Authors: Franzé Javier
Published: April 2020

RESUMENEste artículo busca abordar una cuestión que parece cobrar relevancia política en sociedades postmodernas y secularizadas: las implicaciones que para la ética política puede tener el considerar el mundo como un lugar vacío de sentido inherente o, por el contrario, como una realidad moral. Para ello se recupera la crítica que autores como Leo Strauss y Eric Voegelin, apoyados en una visión clásica de la política que reunía verdad y política, hicieron de Max Weber, cuya reflexión partía de la imposibilidad de fundamentar objetivamente los valores y, por tanto, de conciliar verdad y política. La cuestión que se abre es si una perspectiva que, como la clásica, busca reunir verdad y política, no puede resultar paradójicamente menos consistente para dar cuenta de la especificidad de la ética política que otra que, como la weberiana, da por sentado la imposibilidad de tal reunión.PALABRAS CLAVEPOLÍTICA, VERDAD, ÉTICA, VALORES, VIOLENCIA, WEBER, STRAUSS, VOEGELINABSTRACTThis article deals with an issue that seems to become relevant in postmodern and secularized societies: the implications for political ethics of considering the world as a place without any essential and inherent meaning or, on the contrary, as a moral reality. In order to do this, we recover the criticism made by authors like Leo Strauss and Eric Voegelin –based on a classical concept of politics, joining truth and politics together–of Max Weber’s point of view, starting from the impossibility of objectively founding values and thus, of reconciling truth and politics. The question that arises is, if one perspective looks to join truth and politics together, as does the classical one, it cannot be paradoxically less able to portray the particularity of political ethics than another, like the Weberian one, which supposes the impossibility of the union of truth and politics.KEY WORDSPOLITICS, TRUTH, ETHICS, VALUES, VIOLENCE, WEBER, STRAUSS, VOEGELIN.
La sombra de Ockham es alargada. El influjo ockhamista en las corrientes racionalistas modernas y la rectificación poliana
Authors: Sellés Juan F.
Published: April 2020

RESUMENEn este trabajo se resume la influencia del pensamiento de Ockham en las corrientes de filosofía modernas de corte racionalista: racionalismo, Ilustración, idealismo y fenomenología y estructuralismo. Para notar dicho influjo, se atiende tanto al método cognoscitivo de dichas corrientes como al tema real por ellas tratado. A la par, se establece una sucinta corrección de sus tesis principales desde la filosofía de L. Polo.PALABRAS CLAVEOCKHAM, RACIONALISMO, ILUSTRACIÓN, IDEALISMO, FENOMENOLOGÍA, ESTRUCTURALISMO, L. POLOABSTRACTIn this paper we study the influence of the philosophy of G. of Ockham in some rationalistic modern philosophies: rationalism, Illustration, idealism, phenomenology and structuralism. We focus on the principal method and theme of these philosophies. We also add a brief correction of these thesis according to the philosophy of L. Polo.KEY WORDSOCKHAM, RATIONALISM, ILLUSTRATION, IDEALISM, PHENOMENOLOGY, STRUCTURALISM, L. POLO
Cultura y traducción
Authors: Martínez García Adela
Published: April 2020

RESUMENEn este artículo vamos a tratar la complejidad de la noción de cultura. La cultura ha sido tratada por muchos movimientos y por muchos pensadores. Nos centraremos en algunos de ellos y sobre todo en García Morente. La cultura es el ámbito en que se mueve todo y de modo especial el lenguaje; el marco ineludible y el mayor reto de la traducción.PALABRAS CLAVECULTURA – CIVILIZACION – TRADUCCION ABSTRACTThe complex notion of culture is the main subject of this article. It has been studied by many movements and scholars, notably by García Morente, whose thesis on culture will be discussed. Everything, as well as language, in its own special way, comes under the scope of culture. Thus culture bound lexical items and concepts being the greatest challenge for the translator.KEYWORDSCULTURE – CIVILIZATION - TRANSLATION
Pluralismo cultural y pertenencia comunitaria (Sobre una acepción de cultura)
Authors: Toscano Méndez Manuel
Published: April 2020

RESUMENEste trabajo se interesa por una acepción de cultura que ha cobrado una indudable importancia en los últimos timepos y que tiene que ver con la definición de identidades y delimitación de fronteras entr grupos. NUestro propósito es no tomar dicha acepción como algo obvio y para ello intentamos recuperar su historicidad refiriéndonos a la oposición entre cultura y civilización que se traza a finales del s. XVIII en Alemania. Lejos de ser un término neutro, el sesgo y las implicaciones filosóficas de cultura nos remiten a lo que Berlin ha denominado la contra-ilustración. PALABRAS CLAVECULTURA-CIVILIZACION-CONTRA-INLUSTRACION-PLURALISMOABSTRACTTHis paper focuses on one respect of cultura that has drawn an unquestionable attention lately. This has to do with the definition of identities and with the drawing of boundaries among groups. Our aim is not to consider it as self-evident. To that end, we try to retrieve its historicity by reerring to the oposition of culture and civiltiation advanced in Germany by the end of the XVIIIth century. Far from being a neutral term, the feature and the philosophic implications of culture lead us to what Berlin has called the counter-Enlightement.KEYWORDSCULTURE-CIVILITATION-COUNTER-ENLIGHTEMENT-PLURALISM
Ultralight Covalent Organic Framework/graphene Aerogels with Hierarchical Porosity
Authors: Li Changxia , Yang Jin , Pachfule Pradip , Li Shuang , Ye Meng-Yang , Schmidt Johannes , Thomas Arne
Published: April 2020

The fabrication of macroscopic architectures of covalent organic frameworks (COFs) instead of powders is of great significance to fully exploit their chemical functionality and porosity and to enable sufficient diffusion and mass transfer through the material. However, it is still a challenge to achieve the assembly of such 3D hierarchical porous architectures from COFs. Herein, COF/reduced graphene oxide (rGO) aerogels are presented, which are synthesized by a hydrothermal approach. The COFs grow in situ along the surface of the 2D graphene sheets, which are stacked in a 3D fashion, forming an aerogel after freeze-drying, which can be compressed and expanded several times without breaking. Thus, a facile, green and pyrolysis-free synthetic method for ultralight functional materials has been achieved. The COF/rGO aerogel shows excellent absorption capacity (uptake of > 200 g organic solvent/g aerogel), which can be used for removal of various organic liquids from water. Moreover, as active material of supercapacitor devices, the aerogel delivers a high capacitance of 269 F g-1 at 0.5 A g-1 and superior cycling stability over 5000 cycles, which is among the best results reported for COF-based supercapacitors so far. This work demonstrates a great advance for green synthesis of ultralight materials for environmental and energy applications.
Discovering new lipidomic features using cell type specific fluorophore expression to provide spatial and biological specificity in a multimodal workflow with MALDI IMS
Authors: Jones Marissa A. , Cho Sung Hoon , Patterson Nathan Heath , Van de Plas Raf , Spraggins Jeffrey , Boothby Mark R. , Caprioli Richard M.
Published: April 2020

Identifying the spatial distributions of biomolecules in tissue is crucial for understanding integrated function. Imaging Mass Spectrometry (IMS) allows simultaneous mapping of thousands of biosynthetic products such as lipids but has needed a means of identifying specific cell-types or functional states to correlate with molecular localization. We report here advances starting from identity marking with a genetically encoded fluorophore. The fluorescence emission data were integrated with IMS data through multimodal image processing with advanced registration techniques and data-driven image fusion. In an unbiased analysis of spleens, this integrated technology enabled identification of ether lipid species preferentially enriched in germinal centers. We propose that this use of genetic marking for microanatomical regions of interest can be paired with molecular information from IMS for any tissue, cell-type, or activity state for which fluorescence is driven by a gene-tracking allele and ultimately with outputs of other means of spatial mapping.
Implementasi Nilai-Nilai Aqidah Akhlaq Dalam Meningkatkan Kepedulian Sosial
Authors: Rohmah Maftuchatur , Masruroh Layli
Published: April 2020

One of the subjects taught at school is Aqidah Akhaq. This learning is done to instill good aqidah and morality to students. But with just learning it seems lacking without any implementation of the learning. The title of this research is "implementation of the values of aqidah akhlaq in increasing social awareness of case studies in class X MA al Qur'an La Raiba Hanifida" with a focus of research on the values of aqidah akhlaq students of MA al Quran La Raiba Hanifida and how it is implemented towards social care. The purpose of this research is to find out the implementation of Aqeedah Ahlaq towards social care case studies in class X MA al Quran La Raiba Hanifida. This research uses descriptive qualitative. Ways to collect data by interview, observation and documentation. While data collection techniques by reducing data and verifying data. Based on the results of research conducted that the values or attitudes of students of class X MA al Qur'an La Raiba Hanifida differ from one another. This is influenced by different family backgrounds, schools and environments. To equalize and increase the social awareness of students at the MA al Qur'an, La Raiba Hanifida collaborates with pesantren to hold several activities that are expected to be able to increase the social awareness of students. Among these activities include: teaching asthma pilgrims, teaching flash pupils and TPQ, training, engaging in all events, social and social services.
Análise da variabilidade climática do município de Garanhuns, Pernambuco – Brasil (Analysis of climate variability in the city of Garanhuns, Pernambuco - Brazil)
Authors: Barbosa Vanessa Vasconcelos , De Souza Weronica Meira , Galvíncio Josiclêda Dominicano , Costa Valéria Sandra de Oliveira
Published: April 2020

A investigação das tendências climáticas e das possíveis mudanças do comportamento climático associado aos registros de alterações climáticas globais auxilia na redução da vulnerabilidade às oscilações do regime de precipitação. Este trabalho teve como objetivo avaliar as tendências climáticas da precipitação pluviométrica e dos índices de extremos climáticos no município de Garanhuns, Pernambuco - Brasil. Foram utilizados dados diários de precipitação no período de 1961 a 2014, fornecidos pelo Instituto Nacional de Meteorologia-INMET. Para atingir o objetivo proposto foi utilizado o software Climap para analisar a tendência da precipitação e dos índices de extremos climáticos, assim como o teste sequencial de Mann-Kendall para verificar o ano aproximado em que as tendências tiveram início. Os resultados indicaram que não houve tendências nas séries dos totais anuais e nos índices de extremos de precipitação. Porém, constatou-se uma possível alteração na série de precipitação total anual a partir de 2003, e a predominância da alta variabilidade anual da precipitação pluviométrica na região.  ABSTRACT   The investigation of climate trends and possible changes in climate behavior associated with records of global climate change helps in reducing vulnerability to fluctuations in precipitation regime . This study aimed to assess climate trends of rainfall and climatic extremes indices in the city of Garanhuns , Pernambuco – Brazil. Daily rainfall data were used from 1961 to 2014 , provided by the National Institute of Meteorology - INMET . To achieve purpose we used the CLIMAP software to analyze the trend in rainfall and indices of extremes climatic, as well as the sequential Mann- Kendall to check the trend. The results indicated that there was no trend in the series of indexes of extremes climatic and the total annual precipitation. However , there was a possible change in annual rainfall from 2003 , and high annual variability of rainfall in the region. Keywords: climate, rainfall, Climap.
Infiltración del tronco encefálico en enfermedades hemato-oncológicas avanzadas; manifestaciones clínicas y orientación diagnostica
Authors: Hernández Rivera Anamaría , Barrera Castro Sandra Milena
Published: April 2020

El compromiso de los nervios craneales secundario a progresión de enfermedades oncológicas al tronco encefálico es una entidad infrecuente con alto riesgo de pérdida funcional, su presentación clínica varía de acuerdo con la naturaleza del diagnóstico y la estructura afectada.

Dentro de las enfermedades con mayor riesgo de progresión al tronco encefálico se encuentran las malignidades hematológicas que pueden infiltrar los núcleos de los nervios craneales de forma directa, proceso denominado neurolinfomatosis. El propósito de este artículo es describir las manifestaciones clínicas del compromiso de los nervios craneales en el tronco encefálico secundario a infiltración, mediante la presentación de casos clínicos y una breve revisión de la literatura con el fin de brindar elementos que faciliten la orientación de las intervenciones diagnósticas y terapéuticas por parte del servicio de Rehabilitación.
Caracterización funcional y calidad de vida en pacientes con enfermedad de Parkinson en un hospital de tercer nivel de Bogotá D.C., Colombia
Authors: Avendaño-Avendaño Sandra Bibiana , Bernal-Pacheco Oscar , Esquivia-Pájaro Carmen Teresa
Published: April 2020

Introducción. La enfermedad de Parkinson es considerada la segunda enfermedad neurodegenerativa que más genera discapacidad motora y neuropsiquiátrica; es un trastorno de causa multifactorial cuyo síntoma cardinal es la bradicinesia, seguida de temblor, rigidez e inestabilidad postural, síntomas que impactan la funcionalidad y la calidad de vida del pacien- te. Estudios epidemiológicos muestran que la prevalencia del Parkinson en Colombia es de 4,7 afectados por cada 1.000 personas mayores de 50 años, por lo que es necesario cuantificar el compromiso y las necesidades de atención de estos pacientes. Objetivos. Hacer una caracterización funcional y de la calidad de vida de 60 pacientes con enfermedad de Parkinson atendidos en un hospital de tercer nivel de Bogotá D.C., Colombia, entre noviembre de 2015 y junio de 2016. Materiales y métodos. Estudio de corte transversal con componente analítico realizado en 60 pacientes que cumplieron los criterios de inclusión. Se aplicó el cuestionario de calidad de vida PDQ-39 y la escala de funcionalidad para pacientes con enfermedad de Parkinson MDS- UPDRS. Resultados. El promedio de edad de la muestra fue 67 años, con un rango entre 40 y 84 años, y el 55% eran hombres. El mayor deterioro se evidenció en los dominios de movilidad, activi- dades de la vida diaria, cognición y molestias corporales. Conclusiones. La muestra examinada evidenció un compromiso moderado en la calidad de vida, en los dominios de movilidad y las actividades de la vida diaria. En el aspecto funcional, clínicamente se encontró un compromiso motor en los aspectos de bradicinesia, marcha y rigidez.
Modelo pedagógico ML-SAI: reflexões sobre o perfil do professor e do aluno
Authors: Martins Ernane Rosa , Gouveia Luís Borges
Published: April 2020

O modelo pedagógico ML-SAI apresentado neste trabalho, é fundamentado na teoria da Sala de Aula Invertida (SAI) e tem como propósito orientar as atividades de m-learning. Este artigo tem como objetivo relatar a aplicação do ML-SAI em cursos de nível Superior e Médio de uma instituição federal de ensino, com o uso dos smartphones dos próprios alunos e promover algumas reflexões sobre o perfil dos alunos e dos professores neste contexto. Os resultados encontrados possibilitaram observar que o ML-SAI permite que o professor seja mais flexível e adapte as aulas às características mutáveis do contexto escolar e as reais necessidades dos seus alunos. Os alunos têm um processo educativo mais personalizado, ativo e participativo, com uma aprendizagem centrada no estudante, focada no trabalho prático, interativo e relacionado com situações específicas que visam a resolução de problemas e o desenvolvimento de habilidades.
Analisis Metode Clustering Pada Wilayah Berdasarkan Jenis Pencemaran Lingkungan Hidup
Authors: Fania Fira , Azzahra Mustika , Windarto Agus Perdana
Published: April 2020

This study uses a grouping model in determining areas based on the type of environmental pollution. This study is a special reference from the government in improving environmental sustainability. The data from this study was taken from the website of the government statistical data provider, BPS (Statistics Indonesia) www.bps.go.id. This research uses the K-Mens method and releases it with RapidMiner software to create 2 clusters, high and low level clusters and see what the contents of the cluster are. From the research results obtained by high cluster centroid data that is ((1527), (810.4), (5865), (6655.3), (323), (315.1)) low cluster namely ((139.25) , (122.5), (508,833), (919,222), (64,417), (94,444)). With this analysis, it is expected to be able to load and information for the government to pay more attention to regions whose income is still below average.
Penerapan K-Means Dalam Mengelompokkan Nilai Tambah Industri Besar/Sedang Menurut Kabupaten/Kota
Authors: Aryani Pika , Meyliza Ema
Published: April 2020

Each region must have industries both primary industries, secondary industries, manufacturing industries, construction industries, service industries and the quarter industry. These industries must produce an output that will be used or consumed by consumers or the public. More and more industries in a region indicates that the region has a lot of market demand from the community and the more industries, the income in the industry of a region increases. In this study the data was taken from a government website namely BPS (Statistics Indonesia) - www.bps.go.id which is a website that presents various statistical data from each region. There are 2 clusters in this study, namely high level clusters (C1) and low level clusters (C2). This study stopped at the 2nd iteration and there were centroid data generated namely high level centroid (78177, 56543, 42610, 155596) and low level centroid namely: ((3513.3), (3448.8), (2390.9) ), (4568)). From the calculation process that has been carried out there are 2 high-level districts / cities namely (Deli Serdang and Medan) and 31 other low-level districts / cities. It is hoped that this research can be input to the government in each region to inform the output data generated from industry in each region, and then the data can be used whenever needed.
Evaluación de receptores GPS de bajo costo de alta sensibilidad para trabajos geodésicos. Caso de estudio: línea base geodésica
Authors: Zamora Maciel Alejandra , Romero-Andrade Rosendo , Moraila-Valenzuela Carlos R. , Pivot Fredériqué
Published: April 2020

Se evalúa una línea base geodésica mediante la implementación de antenas y receptores de bajo costo en sistemas embebidos, así como un receptor geodésico de una frecuencia. Estas mediciones fueron ligadas a una estación de referencia continua de la Red Geodésica Nacional Activa, ubicada en Culiacán, Sinaloa, con el objetivo de determinar la precisión de los equipos de bajo costo estudiados. Para ello se analizan las coordenadas y distancias obtenidas al aplicar el método de posicionamiento diferencial con software académico y comercial. Los resultados presentan diferencias de orden milimétrico entre el posicionamiento con un receptor geodésico y uno de bajo costo para una línea base de 5.1 km que hacen posible la utilización de equipos de bajo costo en trabajos geodésicos y topográficos.
Arbitraža po uzoru na rimsko pravo u graničnom sporu između Lovrana i Mošćenica (1646.)
Authors: Milotić Ivan
Published: April 2020

Granični spor između Lovrana i Mošćenica iz 1646. godine
poznat je u literaturi, dok je arhivski izvor u kojemu je zabilježen paleografski i
filološki odgovarajuće obrađen i vrednovan. Premda je riječ o pravnom aktu,
njegova je pravna odrednica nepoznata, što se posebno odnosi na nekoliko
instituta, pojmova i izričaja koji svojom preciznošću, određenošću i
pravnotehničkom izraženošću odudaraju od mjesnih feudalnih običajnih pravnih
shvaćanja toga vremena. K tome, premda su ti pojmovi te izričaji u ispravi
dokumentirani na talijanskome, oni su prigodno talijanizirani, a zapravo
pripadaju latinskom jeziku. Dodatno, kada se spominju, oni odstupaju od
uobičajene srednjovjekovne deskriptivnosti pravnoga jezika i administrativno-funkcionalnog stila kojima
obiluje tadašnja pravna diplomatika. Kako sve navedene naznake upućuju na mogućnost
da su ključni pojmovi, izričaji i instituti u lovransko-mošćeničkom
razgraničenju preuzeti iz rimske pravne tradicije koja je na ovo područje
prodirala i posredstvom ius commune te dijelom iz rimsko-kanonskoga procesa, u
radu se propituje njihovo pravno podrijetlo te uloga i svrha koja se njihovim
korištenjem postizala u konkretnom razgraničenju. U radu se posebna pažnja
posvećuje procesnom mehanizmu kojim je riješen granični spor između Lovrana i Mošćenica te mogućnosti da je on oblikovan po uzoru na rimsku arbitražu i
donekle na rimsko-kanonski proces.
Serum albumin and the risk of contrast-induced acute kidney injury after percutaneous coronary intervention
Authors: Wang Ya , Sun Wen-Jing , Ji Ze-Sheng , Liu Chong-Bin , Wang Rui
Published: April 2020

Serum creatinine and serum albumin levels were measured prior to surgery, and serum creatinine level was also measured at 72 hours following percutaneous coronary intervention in 819 (January 1st, 2015 and December 31th, 2018). According to whether patients developed contrast-induced acute kidney injury or not, they were assigned to either a contrast-induced acute kidney injury group (72 cases, 8.8%) or a non-contrast-induced acute kidney injury group (747 cases; control). Serum albumin was significantly lower in the contrast-induced acute kidney injury group than control (39.33 ± 5.09 g/l and 42.69 ± 5.19 g/l, respectively, P < 0.001). The results of a receiver-operating curve analysis indicated a serum albumin level of 40.5 g/L was the optimal cut-off value for prediction of contrast-induced acute kidney injury and according to a multivariate logistic regression analysis, serum albumin was an independent biomarker for prediction of (95% confidence interval: 0.836-0.935, odds ratio: 0.884, P < 0.001). Serum albumin, a low-cost and easily assessable laboratory protein, was independently related to a greater risk of contrast-induced acute kidney injury among patients that received percutaneous coronary intervention. It is proposed that under these circumstances SA is a potential biomarker for contrast-induced acute kidney injury.
Estimating power in (generalized) linear mixed models: an open introduction and tutorial in R.
Authors: Kumle Leah , Vo Melissa L.-H. , Draschkow Dejan
Published: April 2020

Linear mixed-effect models are a powerful tool for modelling fixed and random effects simultaneously, but do not offer a feasible analytic solution for estimating the probability that a test correctly rejects the null hypothesis. Being able to estimate this probability, however, is critical for sample size planning, as power is closely linked to the reliability and replicability of empirical findings. Although various tools for conducting a simulation-based power analysis for mixed-effect models are available, there is a lack of guidance on how to appropriately use them in different scenarios. In this tutorial paper, we discuss and elaborate how to estimate power for mixed-effects models in different use cases and outline important considerations and pitfalls. We provide code and resources for performing simulation-based power analyses on openly accessible data sets. Our aim is to help researchers build intuitions about simulation-based power analyses and empower them to set up highly powered research designs when sophisticated analysis procedures like mixed-effect models are outlined as inferential procedures.
Development of Learning Tools with the Discovery Learning Model to Improve the Critical Thinking Ability of Mathematics
Authors: Putri Anike , Roza Yenita , Maimunah Maimunah
Published: April 2020

This research was motivated by the still limited learning of mathematics as a means of supporting learning in the 2013 Curriculum. The purpose of this study was to produce some products in the form of learning devices (syllabus, RPP and LKPD) on the material for the flat side building of VIII Middle School with discovery learning models that meet valid, practical, and effective criteria for improving students mathematical critical thinking skills. Learning tools are developed using the 4-D model, which are define, design, develop and assess. The research instrument used was an instrument of validity in the form of a validation sheet to assess the feasibility of the syllabus, RPP and LKPD as well as a practical instrument in the form of a teacher observation sheet activity in applying the discovery learning model and student questionnaire responses to assess the practicality of LKPD. The results of the validation of the experts stated that the product developed reached a valid category with an average rating of 76.67% for syllabus, 76.67% for RPP and 88.04% for LKPD. Learning devices are considered very practical in small group trials with an average response of 96.44% students and large group trials from the observation sheet of teacher activity 93.71% and the average response of students 87.77%. The learning tools have been proved to improve students mathematical critical thinking skills in terms of an average N-gain of 0.53 in the medium category.