bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Trust in Human–AI Collaboration in the Context of Multiplayer Online Games
Authors: Hou Keke , Hou Tingting , Cai Lili
Published: April 2023

Human–AI collaboration has attracted interest from both scholars and practitioners. However, the relationships in human–AI teamwork have not been fully investigated. This study aims to research the influencing factors of trust in AI teammates and the intention to cooperate with AI teammates. We conducted an empirical study by developing a research model of human–AI collaboration. The model presents the influencing mechanisms of interactive characteristics (i.e., perceived anthropomorphism, perceived rapport, and perceived enjoyment), environmental characteristics (i.e., peer influence and facilitating conditions), and personal characteristics (i.e., self-efficacy) on trust in teammates and cooperative intention. A total of 423 valid surveys were collected to test the research model and hypothesized relationships. The results show that perceived rapport, perceived enjoyment, peer influence, facilitating conditions, and self-efficacy positively affect trust in AI teammates. Moreover, self-efficacy and trust positively relate to the intention to cooperate with AI teammates. This study contributes to the teamwork and human–AI collaboration literature by investigating different antecedents of the trust relationship and cooperative intention.
Bone Marrow Transplantation in Nonmalignant Haematological Diseases: What Have We Learned about Thalassemia?
Authors: Castagna Luca , Tringali Stefania , Sapienza Giuseppe , Bono Roberto , Di Maggio Rosario , Maggio Aurelio
Published: April 2023

Allogeneic stem cell transplantation remains the only therapy for congenital, severe haemoglobinopathies that is able to reverse the pathological phenotype. In the severe form of thalassemia, regular transfusions are needed early in life. This population of patients could benefit from allo-SCT. However, the great efficacy of transplantation must be counterbalanced by the mortality and morbidity related to the procedure. In this short review, we reviewed the most recent data in the field of transplantation in transfusion-dependent thalassemia (TDT), highlighting the factors that have a major impact on outcomes.
Evaporation/Decomposition Behavior of 1-Butyl-3-Methylimidazolium Chloride (BMImCL) Investigated through Effusion and Thermal Analysis Techniques
Authors: Brunetti Bruno , Ciccioli Andrea , Gigli Guido , Lapi Andrea , Simonetti Giulia , Toto Elisa , Vecchio Ciprioti Stefano
Published: April 2023

The evaporation/decomposition behavior of the ionic liquid 1-butyl-3-methylimidazolium chloride (BMImCl) was studied with various techniques, such as thermogravimetry (TG), Knudsen effusion mass loss (KEML), and Knudsen effusion mass spectrometry (KEMS), in order to investigate the competition between the simple evaporation of the liquid as gaseous ion pairs (NIP: neutral ion pair) and the thermal decomposition releasing volatile species. TG/DSC experiments were carried out from 293 to 823 K under both He and N2 flowing atmospheres on BMImCl as well as on BMImNTf2 (NTf2: bis(trifluoromethylsulfonyl)imide). Both ionic liquids were found undergoing a single step of mass loss in the temperature range investigated. However, while the BMImNTf2 mass loss was found to occur in different temperature ranges, depending on the inert gas used, the TG curves of BMImCl under helium and nitrogen flow were practically superimposable, thus suggesting the occurrence of thermal decomposition. Furthermore, KEML experiments on BMImCl (in the range between 398 and 481 K) indicated a clear dependence of the unit area mass loss rate on the effusion hole diameter, an effect not observed for the ILs with NTf2 anion. Finally, KEMS measurements in the 416–474 K range allowed us to identify the most abundant species in the vapor phase, which resulted in methyl chloride, butylimidazole, butyl chloride, and methylimidazole, which most probably formed from the decomposition of the liquid.
The Co-Occurrence of T-2 Toxin, Deoxynivalenol, and Fumonisin B1 Activated the Glutathione Redox System in the EU-Limiting Doses in Laying Hens
Authors: Kulcsár Szabina , Kövesi Benjámin , Balogh Krisztián , Zándoki Erika , Ancsin Zsolt , Erdélyi Márta , Mézes Miklós
Published: April 2023

Different mycotoxins in feed lead to combined exposure, increasing adverse effects on animal health. Trichothecene mycotoxins have been associated with inducing oxidative stress, which is neutralized by the glutathione system within the antioxidant defense, depending on the dose and duration of exposure. T-2 toxin, deoxynivalenol (DON), and fumonisin B1 (FB1) are commonly found in feed commodities simultaneously. In the present study, the intracellular biochemical and gene expression changes were investigated in the case of multi-mycotoxin exposure, focusing on certain elements of the glutathione redox system. In a short-term feeding trial, an in vivo study was performed with low (EU-proposed) doses: T-2/HT-2 toxin: 0.25 mg; DON/2-AcDON/15-AcDON.: 5 mg; FB1: 20 mg/kg feed, and high doses (twice the low dose) in laying hens. The multi-mycotoxin exposure affected the glutathione system; GSH concentration and GPx activity was higher in the liver in the low-dose group on day 1 compared to the control. Furthermore, the gene expression of antioxidant enzymes increased significantly on day 1 in both exposure levels compared to the control. The results suggest that when EU-limiting doses are applied, individual mycotoxins may have a synergistic effect in the induction of oxidative stress.
Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil
Authors: Lessa Carlos Letacio Silveira , Hodel Katharine Valéria Saraiva , Gonçalves Marilda de Souza , Machado Bruna Aparecida Souza
Published: April 2023

Arboviruses constitute the largest known group of viruses. These viruses are the etiological agents of pathologies known as arboviruses, with dengue being one of the most prevalent. Dengue has resulted in important socioeconomic burdens placed on different countries around the world, including those in Latin America, especially Brazil. Thus, this work intends to carry out a narrative-based review of the literature, conducted using a study of the secondary data developed through a survey of scientific literature databases, and to present the situation of dengue, particularly its distribution in these localities. Our findings from the literature demonstrate the difficulties that managers face in controlling the spread of and planning a response against dengue, pointing to the high cost of the disease for public coffers, rendering the resources that are already limited even scarcer. This can be associated with the different factors that affect the spread of the disease, including ecological, environmental, and social factors. Thus, in order to combat the disease, it is expected that targeted and properly coordinated public policies need to be adopted not only in specific localities, but also globally.
Probing Diversity of Type II Supernovae with the Chinese Space Station Telescope
Authors: Lin Han , Zhang Jujia , Zhang Xinghan
Published: April 2023

Type II supernovae (SNe II), which show abundant hydrogen in their spectra, belong to a class of SNe with diverse observed properties. It is commonly accepted that SNe II are produced by core collapse and explosion of massive stars. However, the large photometric and spectroscopic diversity of SNe II and the mechanisms responsible for this diversity are not thoroughly understood. In this review, we first briefly introduce the optical characteristics and possible progenitors of each subtype of SNe II. We then highlight the role of the Chinese Space Station Telescope in future SN studies. With a deep limiting magnitude, the main survey project could detect SN IIP-like objects as distant as z∼1.2 and obtain UV-optical follow-up for peculiar transients, especially those long-lived events. With a high resolution and a large field of view, the main survey camera is powerful in linking a nearby SN with its progenitor, while the integral field spectrograph is powerful in revealing the SN environment. All this information has the potential to help enrich our understanding of supernova physics.
Urbanization and Land Use Planning for Achieving the Sustainable Development Goals (SDGs): A Case Study of Greece
Authors: Kalfas Dimitrios , Kalogiannidis Stavros , Chatzitheodoridis Fotios , Toska Ermelinda
Published: April 2023

Sustainable development has attracted the attention of social-economic, spatial well-being, and cultural continuity advocates across the world. However, the processes involved in land use as well as urban development have continued to affect the attainment of sustainable development. This study assessed the effects of urbanization and land use planning on achieving sustainable development goals. The data were collected using a survey questionnaire from 384 different government leaders in Greece. The study showed that the indicators of urbanization quality have a positive effect on sustainable development goals. It was revealed that there is a significant relationship between integrated land use strategies and sustainable development goals. The study showed that indicators of urbanization quality are very key to achieving different SDGs. This indicates that sustainable urbanization entails more than just converting agricultural land and forests without making any changes to them into cities, and it is equally one of the answers to the problem of the world’s population growth if it is done with vision and dedication. The study clearly shows that integrated land use strategies are important in achieving the SDGs. In this case, land use planning is mostly a local effort, though some nations employ guiding land use plans created at the regional or inter-municipal level. Furthermore, urbanization opportunities and land-use plans have a great influence on the achievement of sustainable development goals. Notably, the goal of sustainable urban development is to make urban areas “sustainable” as well as to build or reinforce the city’s sustainability-related economic, social, cultural, and environmental aspects. It then goes on to discover how to spread that idea and why it is important to be focused, using various definitions. The fundamental idea of sustainable urban development is then realized by reviewing the ideas and principles of sustainable development. Finally, some general recommendations are made regarding urban planning, sustainable urban development, and the significance of establishing the necessary conditions for its realization. Urban sustainability and proper use of land require structural changes as well as significant, fundamental shifts at all societal levels.
Developments in Exploring Fungal Secondary Metabolites as Antiviral Compounds and Advances in HIV-1 Inhibitor Screening Assays
Authors: Nzimande Bruce , Makhwitine John P. , Mkhwanazi Nompumelelo P. , Ndlovu Sizwe I.
Published: April 2023

The emergence of drug-resistant Human Immunodeficiency Virus-1 strains against anti-HIV therapies in the clinical pipeline, and the persistence of HIV in cellular reservoirs remains a significant concern. Therefore, there is a continuous need to discover and develop new, safer, and effective drugs targeting novel sites to combat HIV-1. The fungal species are gaining increasing attention as alternative sources of anti-HIV compounds or immunomodulators that can escape the current barriers to cure. Despite the potential of the fungal kingdom as a source for diverse chemistries that can yield novel HIV therapies, there are few comprehensive reports on the progress made thus far in the search for fungal species with the capacity to produce anti-HIV compounds. This review provides insights into the recent research developments on natural products produced by fungal species, particularly fungal endophytes exhibiting immunomodulatory or anti-HIV activities. In this study, we first explore currently existing therapies for various HIV-1 target sites. Then we assess the various activity assays developed for gauging antiviral activity production from microbial sources since they are crucial in the early screening phases for discovering novel anti-HIV compounds. Finally, we explore fungal secondary metabolites compounds that have been characterized at the structural level and demonstrate their potential as inhibitors of various HIV-1 target sites.
Mechanistic-Based Classification of Endocytosis-Related Inhibitors: Does It Aid in Assigning Drugs against SARS-CoV-2?
Authors: Hessien Mohamed , Donia Thoria , Tabll Ashraf A. , Adly Eiman , Abdelhafez Tawfeek H. , Attia Amany , Alkafaas Samar Sami , Kuna Lucija , Glasnovic Marija , Cosic Vesna , Smolic Robert , Smolic Martina
Published: April 2023

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) canonically utilizes clathrin-mediated endocytosis (CME) and several other endocytic mechanisms to invade airway epithelial cells. Endocytic inhibitors, particularly those targeting CME-related proteins, have been identified as promising antiviral drugs. Currently, these inhibitors are ambiguously classified as chemical, pharmaceutical, or natural inhibitors. However, their varying mechanisms may suggest a more realistic classification system. Herein, we present a new mechanistic-based classification of endocytosis inhibitors, in which they are segregated among four distinct classes including: (i) inhibitors that disrupt endocytosis-related protein–protein interactions, and assembly or dissociation of complexes; (ii) inhibitors of large dynamin GTPase and/or kinase/phosphatase activities associated with endocytosis; (iii) inhibitors that modulate the structure of subcellular components, especially the plasma membrane, and actin; and (iv) inhibitors that cause physiological or metabolic alterations in the endocytosis niche. Excluding antiviral drugs designed to halt SARS-CoV-2 replication, other drugs, either FDA-approved or suggested through basic research, could be systematically assigned to one of these classes. We observed that many anti-SARS-CoV-2 drugs could be included either in class III or IV as they interfere with the structural or physiological integrity of subcellular components, respectively. This perspective may contribute to our understanding of the relative efficacy of endocytosis-related inhibitors and support the optimization of their individual or combined antiviral potential against SARS-CoV-2. However, their selectivity, combined effects, and possible interactions with non-endocytic cellular targets need more clarification.
SARS-CoV-2 N-Antigen Quantification in Respiratory Tract, Plasma and Urine: Kinetics and Association with RT-qPCR Results
Authors: Parraud Delphine , Maucotel Anne-Lise , Bouscambert Maude , Morfin Florence , Bitker Laurent , Chidiac Christian , De Castro Nathalie , Frobert Emilie , Gaymard Alexandre ,   on behalf of the French COVID Cohort Study Group
Published: April 2023

Qualitative SARS-CoV-2 antigen assays based on immunochromatography are useful for mass diagnosis of COVID-19, even though their sensitivity is poor in comparison with RT-PCR assays. In addition, quantitative assays could improve antigenic test performance and allow testing with different specimens. Using quantitative assays, we tested 26 patients for viral RNA and N-antigen in respiratory samples, plasma and urine. This allowed us to compare the kinetics between the three compartments and to compare RNA and antigen concentrations in each. Our results showed the presence of N-antigen in respiratory (15/15, 100%), plasma (26/59, 44%) and urine (14/54, 28.9%) samples, whereas RNA was only detected in respiratory (15/15, 100%) and plasma (12/60, 20%) samples. We detected N-antigen in urine and plasma samples until the day 9 and day 13 post-inclusion, respectively. The antigen concentration was found to correlate with RNA levels in respiratory (p < 0.001) and plasma samples (p < 0.001). Finally, urinary antigen levels correlated with plasma levels (p < 0.001). Urine N-antigen detection could be part of the strategy for the late diagnosis and prognostic evaluation of COVID-19, given the ease and painlessness of sampling and the duration of antigen excretion in this biological compartment.
Long COVID and Hybrid Immunity among Children and Adolescents Post-Delta Variant Infection in Thailand
Authors: Jarupan Muttharat , Jantarabenjakul Watsamon , Jaruampornpan Peera , Subchartanan Jarujan , Phasomsap Chayapa , Sritammasiri Taweesak , Cartledge Sapphire , Suchartlikitwong Pintip , Anugulruengkitt Suvaporn , Kawichai Surinda , Puthanakit Thanyawee
Published: April 2023

This study aimed to assess long COVID, and describe immunogenicity against Omicron variants following BNT162b2 vaccination. A prospective cohort study was conducted among children (aged 5–11) and adolescents (aged 12–17) who had SARS-CoV-2 infection from July to December 2021 (Delta predominant period). Long COVID symptoms were assessed by questionnaires at 3 months after infection. Immunogenicity was evaluated by using a surrogate virus-neutralizing antibody test (sVNT) against the Omicron variant. We enrolled 97 children and 57 adolescents. At 3 months, 30 children (31%) and 34 adolescents (60%) reported at least one long COVID symptom, with respiratory symptoms prevailing (25% children and 32% adolescents). The median time from infection to vaccination was 3 months in adolescents and 7 months in children. At 1 month following vaccination, in children who received one-dose and two-dose BNT162b2 vaccines, the median (IQR) sVNT against Omicron was 86.2% inhibition (71.1–91.8) and 79.2% inhibition (61.5–88.9), respectively (p = 0.26). Among adolescents who received one-dose and two-dose BNT162b2 vaccines, the median (IQR) sVNT against Omicron was 64.4% inhibition (46.8–88.8) and 68.8% inhibition (65.0–91.2) (p = 0.64). Adolescents had a higher prevalence of long COVID than children. Immunogenicity against the Omicron variant after vaccination was high and did not vary between one or two doses of the vaccine in either children or adolescents.
Evaluation of an Immunization Protocol Using Bovine Alphaherpesvirus 1 gE-Deleted Marker Vaccines against Bubaline Alphaherpesvirus 1 in Water Buffaloes
Authors: Martucciello Alessandra , Balestrieri Anna , Righi Cecilia , Cappelli Giovanna , Scoccia Eleonora , Grassi Carlo , Brandi Sergio , Rossi Elisabetta , Galiero Giorgio , Gioia Damiano , Fusco Giovanna , Feliziani Francesco , De Carlo Esterina , Petrini Stefano
Published: April 2023

European regulations on the control of infectious diseases provide measures to control Bovine alphaherpesvirus 1 (BoHV-1) infection in both cattle and buffalo. Owing to the reported serological cross-reactivity between BoHV-1 and Bubaline alphaherpesvirus 1 (BuHV-1), we hypothesized a new immunization protocol using BoHV-1 gE-deleted marker vaccines could protect water buffalo against BuHV-1. Five water buffaloes devoid of BoHV-1/BuHV-1-neutralizing antibodies were immunized with two commercial BoHV-1 gE-deleted marker vaccines at 0, 30, 210, and 240 post-vaccination days (PVDs). Five additional water buffaloes were used as controls. At 270 PVD (0 post-challenge days (PCDs), all animals were challenged intranasally with wild-type (wt) BuHV-1. The vaccinated animals produced humoral immunity (HI) as early as PVD 30 whereas, in control animals, antibodies were detected on PCD 10. After challenge infection, HI significantly increased in vaccinated animals compared to that in controls. Real-time PCR for gB revealed viral shedding in vaccinated animals from PCDs 2 to 10. In contrast, positive results were observed from PCDs 2 to 15 in the unvaccinated control group. Although the findings indicated the possible protection capabilities of the tested protocol, these findings did not support its protective roles in water buffaloes against wt-BuHV-1.
LED Light Applied to the Feeder: Impact on Growth Performances of Chickens under Productive Conditions
Authors: Galosi Livio , Falconi Roberto , Biagini Lucia , Corrales Barrios Yulaine , Roncarati Alessandra
Published: April 2023

This study assessed the use of feeders equipped with light-emitting diodes and their effects on the productivity of broiler chickens under productive conditions. A total of 87,200 ROSS 308 chickens, 1-day old, were housed in two poultry houses (CONTROL, F-LED). In CONTROL, 20,000 females (mean body weight 41.12 ± 3 g) and 25,000 males (mean body weight 41.56 ± 3 g) were housed, while 19,200 females and 23,000 males of the same genetic make-up and mean body weight were housed in F-LED under the same environmental conditions. In F-LED, to encourage chickens to feed and to redistribute more feed down the feeding line, a feeder equipped with a LED light has been installed at the end of each line. In CONTROL, no light was located on the feeders. At the end of the cycle, the average body weight never showed significant differences both for females (1345 g in CONTROL; 1359 g in F-LED) and for males (2771 g in CONTROL; 2793 g in F-LED). Uniformity improved in F-LED, at 75.2% in females and 54.1% in males, compared to CONTROL, at 65.7% and 48.5%, respectively, for females and males. The feed conversion ratio followed the same trend, being more favorable in chickens reared in F-LED (1.567) compared to those raised in CONTROL (1.608). The application of a single F-LED at the end of each feeding line demonstrated its utility in improving size uniformity and feed conversion.
Impact of Accessory Corpus Luteum Induced by Gonadotropin-Releasing Hormone or Human Chorionic Gonadotropin on Pregnancy Rates of Dairy Cattle following Embryo Transfer: A META-Analysis
Authors: Chen Fang , Hou Yi’an , Zhu Xiaoqing , Mei Cheng , Guo Rihong , Shi Zhendan
Published: April 2023

The circulation of progesterone (P4) concentrations of recipients has positive correlations with embryo survival and pregnancy success of embryo transfer (ET) in dairy cows. One strategy to improve P4 concentration is the administration of gonadotropin-releasing hormone (GnRH) or human chorionic gonadotropin (hCG), thereby inducing the formation of accessory corpus luteum (CL). This study aimed at determining the efficacy of GnRH or hCG treatment regarding embryo transfer (ET) and providing a better clinical veterinary practice guidance. A meta-analysis was conducted on the data from 2048 treated recipient cows and 1546 untreated cows. By inducing the formation of accessory CL with GnRH (100 µg), GnRH analogue Buserelin (8–10 µg), or hCG (≥1500 IU) 5–11 days after synchronized ovulation, hCG alone achieved an improvement (RR = 1.39, p < 0.05), while GnRH and GnRH analogue did not result in significant changes (RR = 1.04, p = 0.26). Treatment with GnRH or hCG 5–7 days after synchronized ovulation was associated with increased chances of pregnancy compared with later treatment (11–14 days). Owing to the treatment, the pregnancy rate of cows with very poor fertility (<40%) was improved, while that of cows with good fertility (≥40%) was not affected. Treatment with GnRH or hCG greatly improved pregnancy rates of parous lactating cows (RR = 1.32, p < 0.05) compared with heifers (RR = 1.02, p > 0.05). Additionally, as indicated by pregnancy loss analysis, the treatment had no benefit on late embryo/early fetus survival at days 28–81. In conclusion, the induction of accessory CL with GnRH or hCG may benefit fertility and have important implications for the management of reproductive performance in the dairy industry.
Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine
Authors: Ibancovichi José Antonio , Chávez-Monteagudo Julio Raúl , Sánchez-Aparicio Pedro , De Paz-Campos Marco Antonio
Published: April 2023

The impacts of morphine and dexmedetomidine on the MAC of isoflurane were studied in rats constantly medicated with the cannabinoid WIN 55,212-2. Methods: Prior to the administration of morphine, the MAC was measured in both untreated rats (MAC (ISO)) and those treated with a cannabinoid (MAC (ISO + CANN)). The effects of morphine (MAC (ISO + MOR)) and dexmedetomidine (MAC (ISO + DEX)) on untreated rats and rats treated for 21 days with the cannabinoids (MAC (ISO + CANN + MOR)) and (MAC (ISO + CANN + DEX) were also studied. Results: MAC (ISO) was 1.32 ± 0.06, and MAC (ISO + CANN) was 1.69 ± 0.09. MAC (ISO + MOR) was 0.97 ± 0.02 (26% less than MAC (ISO)). MAC (ISO + CANN + MOR) was 1.55 ± 0.08 (8% less than MAC (ISO + CANN)), MAC (ISO + DEX) was 0.68 ± 0.10 (48% less than MAC (ISO)), and MAC (ISO + CANN + DEX) was 0.67 ± 0.08 (60% less than MAC (ISO + CANN)). Conclusions: Medication with a cannabinoid for 21 days augmented the MAC of isoflurane. The sparing effect of morphine on isoflurane is lower in rats constantly medicated with a cannabinoid. The sparing effect of dexmedetomidine on the minimum alveolar concentration of isoflurane is greater in rats repeatedly medicated with a cannabinoid.
Acute Effects of Whole-Body Vibration on Quadriceps Isometric Muscular Endurance in Middle-Aged Adults: A Pilot Study
Authors: Greco Francesca , Quinzi Federico , Folino Katia , Spadafora Marco , Cosco Loretta Francesca , Tarsitano Maria Grazia , Emerenziani Gian Pietro
Published: April 2023

This study analysed the acute effects of whole-body vibration (WBV) on quadriceps isometric muscular endurance. Fifteen healthy middle-aged males performed an endurance isometric strength test after three different warm-up conditions: static half squat plus WBV (HSV), static half squat without WBV (HS), and control condition (CC). The endurance isometric strength test consisted of 10 maximal isometric contractions held for 4 s and interspersed by 2 s of rest between each repetition. Rate of Perceived Exertion (RPE) was assessed after warm-up (RPE1) and at the end of the testing session (RPE2). During each testing session, participant’s heart rate (HR) was continuously recorded. For each trial, the mean force across the 10 repetitions and fatigue index were evaluated. Mean force was significantly higher (p < 0.01) in CC than in the other two conditions. Both RPE1 and RPE2 were significantly lower (p < 0.01) in CC than HSV and HS condition. Warm-up HR and the mean testing session HR were significantly lower in CC than the other two conditions (p < 0.01). No significant differences were observed in fatigue index between conditions (p > 0.05) or in HR during the endurance protocol. Performing half-squat with or without vibration stimuli does not increase isometric muscular endurance and does not influence fatigue index.
Selection of Wastewater Treatment Technology: AHP Method in Multi-Criteria Decision Making
Authors: Ćetković Jasmina , Knežević Miloš , Vujadinović Radoje , Tombarević Esad , Grujić Marija
Published: April 2023

Wastewater treatment is a process that reduces pollution to those quantities and concentrations at which purified wastewater is no longer a threat to human and animal health and safety and does not cause unwanted changes in the environment. Municipal wastewater is classified as biodegradable water. Special importance should be given to wastewater with a high content of organic matter (COD), phosphorus (P) and nitrogen (N). MBBR technology, developed on the basis of the conventional activated sludge process and the bio filter process, does not take up much space and does not have problems with activated sludge, as in the case of conventional biological reactors, and has shown good results for the removal of organic matter, phosphorus and nitrogen. The aim of this paper is to optimize the wastewater treatment process in the municipality of Dojran, North Macedonia. Three alternative solutions for improving the capacity for wastewater treatment in the municipality of Dojran were analyzed. The shortlist of variants was made on the basis of several criteria, including: analysis of the system in the tourist season and beyond, assessment of the condition and efficiency of the existing wastewater treatment plant (WWTP) in combination with a new treatment plant, treatment efficiency when using different wastewater treatment technologies, the size of the site needed to accommodate the capacity, as well as the financial parameters for the proposed system. The selection of the most favorable solution for the improvement of the wastewater treatment system was made using the AHP (analytic hierarchy process) method. In order to select the optimal solution, a detailed analysis was conducted, considering several decision-making criteria, namely the initial investment, operating costs and management complexity. Based on the obtained results, Variant 3 was recommended, that is, the construction of a completely new station with MBBR technology, with a capacity for 6000 equivalent inhabitants.
Research on Water Level Anomaly Data Alarm Based on CNN-BiLSTM-DA Model
Authors: Hu Cancan , Zhou Lanting , Gong Yunzhu , Li Yufei , Deng Siyuan
Published: April 2023

With frequent extreme rainfall events caused by rapid changes in the global climate, many cities are threatened by urban flooding. Timely issuance of flood warnings can help prepare for disasters and minimize losses caused by floods. In this study, we propose a method based on a convolutional neural network-bidirectional long short-term memory-difference analysis (CNN-BiLSTM-DA) model for water level prediction analysis and flood warning. The method calculates and analyzes the difference sequence between water level monitoring values and water level prediction values, compares historical flood data to determine the alarm threshold for abnormal water level data, and achieves real-time flood warnings to provide technical references for flood prevention and mitigation. Taking Yancheng city, a low-lying city located in the plain area of Jiangsu Province in China, as an example, this study verifies the accuracy of the CNN-BiLSTM model in water level prediction, which can achieve an accuracy rate above 95%. This provides a reliable data basis for further determination of warning thresholds using the DA model. The CNN-BiLSTM-DA model achieves an accuracy rate of 85.71% in flood warnings without any missed reports, demonstrating that this method has scientific, practical, and accurate features in addressing flood warning issues.
GESTÃO DE ESTOQUE: APLICAÇÃO DA CURVA ABC PARA MELHORIA NO GERENCIAMENTO DE ESTOQUE EM UMA INSTITUIÇÃO DE ENSINO
Authors: DE LIMA GONÇALVES MAURILHO , ANTÔNIO COUTO FERREIRA MÁRCIO
Published: April 2023

The importance of implementing the ABC method in storage management, presented in this article, is the improvement of stock control in institutions, addressing the importance of items in stock and showing those that have a demand or request in greater quantity. The objective of this study is to evaluate inventory management and its procedures, as well as describe the use of the ABC curve for effective management. A literature review was used as a methodology, so that information based on ideas from various authors can be taken in order to clarify and respond to certain issues addressed. As for the nature of the research, it was developed based on quantitative and qualitative parameters, through data collected from articles and books. It is concluded that the ABC curve is one of the methods that promote and favor inventory management, the classification of items that belong to its class, identifying, in detail, its need for control.
Das kritisch-alternative pädagogische Milieu um 1968. Wissensbewegungen zwischen Handlungspraxis, Politik und Wissenschaft
Authors: Thole Friederike
Published: April 2023

Den bewegten Zeitraum um 1968 als Ausgangspunkt nehmend, untersucht die Arbeit Wissenstransformations- und Zirkulationsprozesse zwischen politischer und pädagogischer Praxis sowie erziehungswissenschaftlicher Theorie. Anhand von neun biographischen Erzählungen mit Personen, die um 1968 in pädagogischen oder politischen Praxisprojekten aktiv waren und danach einen Weg in die Wissenschaft verfolgten, werden Wissensbewegungsprozesse nachgezeichnet. Es wird aufgezeigt, wie sich Wissen des Diskursraums des kritisch-alternativen pädagogischen Milieus durch seine diskursiven Verschränkungen mit der etablierten Erziehungswissenschaft veränderte und sich auch die etablierte Erziehungswissenschaft über die Auseinandersetzung mit den neuen Wissensformen in einem kommunikativen Prozess der Öffnung begab.
Tratamiento sistémico para el cáncer de mama HER2 positivo avanzado. Revisión de la evidencia y abordaje terapéutico en el Instituto Nacional de Cancerología - Colombia
Authors: Martínez Villacrés Juanita , Luna Meza Angela Maria , Ballen Diego Felipe , Suarez Rodríguez Raúl Alexis , Saenz Ladino Anderson , Sánchez Castillo Jesús Oswaldo , Contreras Mejía Fernando , Lehmann Mosquera Carlos , Ángel Aristizabal Javier , Brugés Maya Ricardo , Guzmán Abi-Saab Luis Hernán , Briceño Morales Ximena , Rojas Andrade Eduardo Alfonso , García Mora Mauricio , Mariño Lozano Iván Fernando , Diaz Casas Sandra Esperanza
Published: April 2023

El cáncer de mama es la neoplasia más frecuente y de mayor mortalidad en las mujeres en todo el mundo. El receptor 2 del factor de crecimiento epidérmico humano (HER2) se sobreexpresa en aproximadamente el 20% de las pacientes con cáncer de mama y se asocia a mayor riesgo de recidiva tumoral y mortalidad. Antes del desarrollo de los anticuerpos monoclonales dirigidos contra HER2, el cáncer de mama HER2 positivo estaba asociado con un pronóstico desfavorable. El uso de las terapias dirigidas anti HER2 ha mejorado significativamente las tasas de supervivencia global tanto en el escenario adyuvante como en la enfermedad metastásica. En los últimos años han surgido nuevos medicamentos que bloquean esta vía de señalización, lo cual ha permitido establecer varias líneas de tratamiento con terapia anti HER2 en las pacientes con enfermedad metastásica. Por esta razón, las unidades funcionales de Oncología Clínica / Seno y Tejidos Blandos tomaron la decisión de realizar una revisión de la evidencia científica disponible a octubre de 2021, para establecer las recomendaciones en el abordaje terapéutico de las pacientes con cáncer de mama metastásico HER2 positivo en el Instituto Nacional de Cancerología (INC).
Indicaciones para el uso de pertuzumab en cáncer de mama HER2 positivo no metastásico en los escenarios neoadyuvante y adyuvante. Revisión de la evidencia y abordaje terapéutico en el Instituto Nacional de Cancerología - Colombia
Authors: Quintero Ortiz María Andrea , Ballén Diego Felipe , Briceño Morales Ximena , Bruges Maya Ricardo , Contreras Mejía Fernando , Sánchez Castillo Jesús Oswaldo , Guzman Abi-Saab Luis Hernan , Rojas Andrade Eduardo Alfonso , Mariño Lozano Ivan Fernando , Ángel Aristizabal Javier , Lehmann Mosquera Carlos , Garcia Mora Mauricio , Duarte-Torres Carlos Alfonso , Diaz Casas Sandra Esperanza
Published: April 2023

La adición de la terapia dirigida a la quimioterapia citotóxica en pacientes con cáncer de mama ha mejorado significativamente los desenlaces oncológicos en las pacientes con tumores HER2 positivo. El uso de pertuzumab durante el manejo neoadyuvante incrementa significativamente la respuesta patológica completa y en la actualidad permite emplear regímenes libres de antraciclinas con una eficacia similar y menores efectos cardiovasculares (en especial sobre la fracción de eyección). El beneficio en supervivencia libre de enfermedad invasiva, de adicionar pertuzumab en el escenario adyuvante en las pacientes sin tratamiento anti HER2 previo, está limitado a aquellas con ganglios positivos. La implementación de esquemas con bloqueo dual anti HER2, durante el tratamiento inicial del cáncer de mama HER2 positivo, mejora significativamente el pronóstico oncológico en este grupo de pacientes.
Regulaciones antitrust para Silicon Valley
Authors:   , Komissarov Serguei
Published: April 2023

Esta tesis analiza las regulaciones antimonopolio de los Estados Unidos para Facebook y Google, junto a sus efectos sobre la competencia, en el mercado de las plataformas digitales. Una particular combinación de economías de escala y externalidades de red; sumada a la extracción, recolección, almacenamiento y análisis de datos personales, permite que ambas empresas detenten un poder de mercado dentro de la publicidad digital. Su posición dominante incrementa el precio a los anunciantes publicitarios, deteriora la privacidad de los usuarios, afecta el libre flujo de información en la red, e impide la innovación tecnológica. Durante 2019, estas conductas anticompetitivas motivaron la investigación de las autoridades estadounidenses sobre las industrias de Silicon Valley. El 4 de febrero del 2021, el Subcomité Judicial en Defensa de la Competencia y los Derechos del Consumidor, presentó un proyecto para reformar las leyes antimonopolio. Por su parte, el 24 de junio del 2021, el Comité Judicial de la Cámara de Representantes aprobó un paquete legislativo con cuatro leyes orientadas a regular las conductas anticompetitivas de las plataformas digitales. En esta tesis se analizan las reformas propuestas al marco jurídico antimonopolio y las regulaciones específicas destinadas a las plataformas para promover la competencia en el sector tecnológico.
Beneficios de las intervenciones sobre la calidad de vida en profesionales de la salud
Authors: Soriano-Sánchez José-Gabriel , Jiménez-Vázquez David
Published: April 2023

En los últimos años, las demandas de las organizaciones sanitarias han pasado de fomentar un talento humano de carácter más operativo a desarrollar un profesional que posea un mayor número de capacidades para poder dar una respuesta más competitiva a sus solicitudes y en la cual se fomente la calidad de vida laboral. El objetivo del presente trabajo consistió en identificar mediante una revisión sistemática y metaanalítica los beneficios que aportan los programas de intervención en la percepción de la calidad de vida laboral en el personal de enfermería. Se realizó una búsqueda de investigaciones en las bases de datos Scopus, Web of Science, PsycINFO, CINAHL, PubMed y Psychology Database, obteniendo un total de 56 estudios que, tras aplicar los diferentes criterios, quedaron 5 trabajos para revisión y 2 para metaanálisis. Los hallazgos metaanalíticos revelaron una estimación consistente de efecto positivo que poseen las intervenciones para mejorar la calidad de vida laboral. De hecho, en cada una de las dimensiones (burnout, fatiga por compasión y estrés traumático segundario) la heterogeneidad fue de I² = 0% (p = .00). Los hallazgos expuestos deben tenerse en cuenta para garantizar la calidad de vida de los profesionales sanitarios. En consecuencia, ello podría fomentar una mejora en la calidad asistencial y el alcance de los resultados institucionales y personales deseados.
Tuberculose Óssea em Pediatria: Relato de Caso
Authors: Wemiria de Fátima Lopes  , Angela Gomes de Vasconcellos  , Daniella Baraúna  , Rita de Cássia Mira de Oliveira
Published: April 2023

A tuberculose é um grave problema de saúde pública,especialmente em países subdesenvoldivos e em desenvolvimento. A literatura referente ao acometimento da tuberculose extrapulmonar osteoarticular em crianças é escassa. O presente caso apresenta um diagnóstico etiológico diferencial para um quadro de celulite refratária a antibióticos em Pediatria. Geralmente, o diagnóstico da tuberculose extrapulmonar é feito por exclusão de outras enfermidades e com auxílio da prova tuberculínica. Desta forma, o diagnóstico ocorre tardiamente, o que pode repercutir negativamente no paciente e, por conseguinte, na vida produtiva do futuro adulto.
Thermodynamic analysis of molecular beam epitaxy of group-III sesquioxides
Authors: Togashi Rie , Goto Ken , Higashiwaki Masataka , Kumagai Yoshinao
Published: April 2023

Thermodynamic analyses for the growth of group-III sesquioxides, including α-Al2O3, β-Ga2O3, and c-In2O3, by both ozone and plasma-assisted MBE were performed. In either case, under O-rich conditions, the driving force for III2O3 (III = Al, Ga, In) growth (

Δ

P

III
2

O
3

) increased with increasing input partial pressure of the group-III metal (

P
III
o

), without generation of metal droplets. Conversely, under group-III-metal-rich conditions,

Δ

P

III
2

O
3

decreased with increasing

P
III
o

and/or decreasing input partial pressure of O3 or O. This decrease was caused by the formation of Ga2O or In2O during growth of β-Ga2O3 and c-In2O3. The decrease of

Δ

P

Al
2

O
3

was smaller because the equilibrium constant of α-Al2O3 formation reaction was very large. Ga and In droplets formed at low temperatures (<420 °C), whereas Al droplets were formed at high temperatures (<820 °C), and the order that enabled growth at higher temperatures was c-In2O3 < β-Ga2O3 << α-Al2O3.
EVALUATION OF A MOTHER'S KNOWLEDGE AND PRACTICE INTERVENTION PROGRAM FOR ACUTE RESPIRATORY INFECTIONS IN INDIAN CHILDREN
Authors: Bhardwaj Shubha
Published: April 2023

Acute respiratory Infection (ARI) causes approximately 3.9 million deaths yearly in children under ve
years of age. In developing countries, where malnutrition is prevalent, and indoor air pollution is high,
pneumonia is the leading cause of death. A structured questionnaire is used to collect data from 205 mothers. In addition, their
practice regarding identifying, managing, and treating ARI is suboptimal due to inadequate knowledge about the signs and
symptoms, prevalence, causes, diagnosis, and treatment of ARI. A signicant correlation is found between education and age,
whereas a signicant correlation is found between joint family status and knowledge. The study highlights the importance of
health education for mothers and suggests that nursing personnel can be crucial in counseling mothers in hospital and
community settings
“DOUBLE TENSION BAND OSTEOSYNTHESIS IN DISTAL HUMERUS FRACTURE IN OSTEOPOROTIC ADULTS AND INFECTED NONUNIONS”
Authors: Varma Deepak , Saini Santosh , Seth Pallav , Bhagwan Sharma Shiv
Published: April 2023

Background: It is a challenge for orthopedic surgeon to x osteoporotic distal humerus fracture rigidly for early mobilization because holding power of plate and screws is low in osteoporotic bone fracture and have higher failure rate. Second challenge is to x an infected nonunion of distal humerus fracture because of restriction to use plate and screw. To achieve a stable , pain free and mobile joint require appropriate planning , systematic approach and anatomical reduction. To evaluate effectiveness of double tension band osteosynthesis in distal hume Aim: rus fracture of osteoporotic adult bone and infected nonunions. Ten patients presenting six fractures and three Method: nonunion of the distal humeral ,treated with double tension band wiring between 2018 and 2023 were retrospectively evaluated , two fracture were type A2 , two were type C1, remaining two were type C2 and rest are previously operated infected nonunions. Patients age averaged about 55 years. There are 5 males and 5 females. Out of 10 cases treated with t Results: his method, rigid xation and union was achieved in all of them. Radiological union was achieved at an average of 10.8 weeks (8-14weeks). Average range of motion was 104.5 degrees with maximum range of motion 120 degrees (10-130) and minimum of 70 degrees (30-100). Excellent or good results were obtained in 80% of the patients in our study. Double tension b Conclusion: and is a reliable, less demanding and cost effective method of xation of distal fractures of humerus in osteoporitic adults and infected nonunions.
A RETROSPECTIVE ANALYSIS OF HISTOPATHOLOGICAL FINDINGS IN RHINOORBITAL FUNGAL INFECTION IN POST COVID 19 PATIENTS
Authors: Patel Komal , Patel Mubin , Padsala Suresh , Chaudhary Pallavi , Patel Mandakini , Dabhi Heer
Published: April 2023

Introduction: Health care sector across India reported signicant increase in cases of covid linked mucormycosis and other fungal infections in covid 2nd wave. Mucormycosis is an opportunistic fulminant fungal infection in immunocompromised host. Concomitant diabetes and use of high dose steroid, further add to already compromised immunity in covid patients. It may manifest as rhino-orbital or cerebral mucormycosis. Fungus invades the arterioles and causes tissue necrosis, which is the hallmark of mucormycosis. Objectives: To study frequency and histomorphology of various tissue invasive fungal infections and their corelation with other parameters. Material and Methods: This is retrospective observational study. Here we present histological and other ndings in 236 cases of clinically suspected post covid fungal infection during 2-month periods. Out of 236 specimens received Result: , 211 showed presence of tissue invasive fungal infection with positivity rate of 89.4%, where male to female ratio was 2.2:1, mean age was 51 years. Most common organism detected was mucor species in 72%, Aspergillus in 4.3% and 23.7% had mixed infection. Angioinvasion was seen in 38.86%. The most common site of involvement was sinonasal (84.36%) followed by orbital (15.16%) and cerebral (0.47%). 68.18% patients were diabetics, 39% had history of moderate to severe covid requiring oxygen, 72.7% had received steroid. Conclusion: Diabetes mellitus and rampant use of corticosteroid in a background of Covid-19 appears to increase opportunistic fungal infection. Mucor and aspergillus were commonly observed tissue invasive and angioinvasive fungal species.
TICAGRELOR VS. CLOPIDOGREL: CLINICAL OUTCOMES IN ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS
Authors: Ahmed Bhat Rafiq , Manzoor Ali Syed , Maqbool Syed , Rathi Akanksha , Islam Monowarul , Saqib Iqbal Raja , Awadh Abdun Mohammed , Bin Latief Usama , Dwivedi Atul , Yuan PengCheng , Muwei Li , Zhu Zhongyu , Qu Yongsheng , Zhang You , Xiao Wentao , Xingkun Zhang , Gao Chuanyu
Published: April 2023

A large, randomised control trial known as PLATO study proved a turning point in the assessment of superiority of ticagrelor over clopidogrel in
post- MI cases. This breakthrough in assessing the quantum of efcacy of ticagrelor over clopidogrel in post-MI patients led to changes in
international guidelines. However, based on the mortality index associated with these two drugs, the outcome is not encouraging, and both
ticagrelor and clopidogrel are on par in terms of efcacy or safety. Recurrent episodes of bleeding were more common in patients who were
prescribed ticagrelor than in patients who were given clopidogrel. However, future trials with longer follow-up time periods may be able to answer
all the remaining questions
KNOWLEDGE, SUPPORT, AND PRACTICE TOWARDS BREAKFAST FOR MOTHERS OF SCHOOL-AGE CHILDREN IN A VILLAGE (SUDAN)
Authors: Abdallah Ali Eshraga
Published: April 2023

This research aims to identify the cognitive information about the importance of breakfast for children in the primary stage and to know the
practices that are practiced in preparing this meal. Aquestionnaire was used for this research, and a random sample of 70 women was selected from
the the-Azaza village in the Singa countryside. The questionnaire was analyzed using statistical analysis software. The research concluded that
85.7% of children's mothers are interested in breakfast, 80% of children are supported and encouraged to eat breakfast, and 95.7% of school
children eat breakfast at home. Breakfast consists of cooked red beans 1.47% and porridge with milk 30%, and it was found that 5% do not eat
breakfast daily due to lack of income and lack of food. The dietary pattern depends on vegetable protein and a lack of vegetables, where the
percentage was 97.1%, and the lack of fruits 88.6%. The research came out with several recommendations, the most important of which is the need
to support poor families with limited income to provide breakfast for their children and spread awareness of the importance of eating vegetables and
fruit