bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical Treatment of Old Pelvic Ring and Lower Urinary Tract Injuries in Men
Authors: Lazarev A. F , Gudushayri Ya. G , Verzin A. V , Solod E. I , Kakabadze M. G , Roskidailo A. S , Stoyukhin S. S
Published: October 2020

Surgical treatment results for 56 men with old pelvic bones and junctions injuries complicated or associated with either strictures or obliteration of membranous and bulbomembranous urethral segment are presented for the period from 2002 to 2013. Terms after trauma made up from 1 month to 6 years, mean age of patients - 36 (16-66) years. All patients were admitted with epicystoma and history of 3-5 failed surgical interventions directed to uresis restoration. The pattern of pathologic mobility, degree of pelvic ring injury, length of urethral defect, and connec- tion of urethra with either bone fragments or displaced pelvic bones were assessed during complex urologic and traumatologic examination. Treatment tactics, i.e. one- or two-step, was chosen depending on the diagnosed injuries. In two-step treatment tactics orthopaedic step always preceded the urologic one (urethra plasty) that followed in about 2 months after primary intervention. Observation terms made up from 1 month to 6 years. Loco-motor function was restored in all patients, urination - in 54 of 56 patients. Thus, elaborated method of surgical treatment for old concomitant pelvic ring and lower urinary tract injuries showed high efficacy in patients with posttraumatic urethral stricture or obliteration
Effect of Autologous Plasma, Ascorbic Acid and Glucose Local Infusions on Pelvic Fracture Healing in Experiment
Authors: Silant’eva T. A , Krasnov V. V
Published: October 2020

The efficacy of reparative osteogenesis stimulation by local infusion of autologous plasma in combination with ascorbic acid and glucose solutions was experimentally demonstrated in ani- mals (dogs) using the models of transverse acetabular ( n =20) and iliac shaft fracture ( n= 6). Either intraarticular or intraosseous solution infusions via injection system with automatic drug pump were performed from 2nd to 5th day after transverse osteotomy, reposition and stable external fixation. Fixator was dismounted on 21st postoperative day. In control series of experiment (intraarticular and intraosseous infusion of saline) fibrocartilagenous junction was formed and bone deformity due to secondary bone fragments displacement was noted after device removal. In experimental series primary pelvic bone fragments consolidation was observed in 14 days after operation and no displacement of fragments occurred after external fixation device removal.
Temporary Noninvasive Pelvic Stabilization
Authors: Samokhvalov I. M , Borisov M. B , Denisenko V. V , Grebnev A. R , Ganin E. V
Published: October 2020

Pelvic ring stabilization is the basic emergency care measure in unstable pelvic injuries. The purpose of the work was to determine the efficacy of pelvic bandage in patients with unstable pelvic fractures and persistent intrapelvic hemorrhage. Thirty seven patients were divided into 2 groups. In study group (n=19) primary pelvic stabilization was performed using extempore pelvic bandage; in patients from control group (n=18) external fixation devices were applied. Duration of pelvic fixation procedure, hemodynamics and quality of reposition were assessed. Duration of pelvic bandage application was significantly lower than that required for pelvic external fixation - 2.4±0.8 min versus 29±3.2 min. That advantage enabled to use the bandage before the diagnosis was completed and other injuries were eliminated - in 6.0±2.1 min after patient’s admission while the time before the application of external fixation device made up 86.0±5.6 min ( p < 0.001). Application of pelvic bandage enabled to stabilize blood pressure in the course diagnostic and treatment measures. In some cases pelvic roentgenography revealed excessive internal rotation when bandage was applied. So, application of pelvic bandage is a simple, effective, rapid method for temporary pelvic fixation.
Microsurgical Reconstruction of Soft Tissues in Elbow Arthroplasty
Authors: Kalantyrskaya V. A , Golubev I. O , Afonina E. A
Published: October 2020

Case report on a patient with severe traumatic elbow joint destruction in whom consecutive restoration of common integument (with free Latissimus dorsi musculocutaneous flap) and elbow arthroplasty were performed is presented
Efficacy of Autologous Growth Factors Application in Musculo-Skeletal System Injuries and Diseases
Authors: Mironov S. P , Ochkurenko A. A , Kesyan G. A , Savel’ev S. N , Arkad’ev A. A , Zbarag N. N
Published: October 2020

Literature review on the assessment of the efficacy of platelet rich autoplasma for the treatment of various musculo-skeletal system diseases - tendinopathy, osteoarthrosis, injuries of ligaments, tendons, muscles and bones is presented. Platelet rich autoplasma contains growth factors and secretory proteins that can start up remodeling and restorative processes in pathologic tissues. The method showed itself to be effective, safe, free from side effects and complications. Most of the research workers consider it reasonable to conduct randomized controlled studies in order to receive reliably data on this methods efficacy.
Analysis of Results of Kyphotic Deformity Reduction Using Puncture Vertebroplasty and Stenoplasty in Patients with Traumatic Compression Fractures of Thoraco-Lumbar Localization
Authors: Byval’tsev V. A , Kalinin A. A , Sorokovikov V. A , Belykh E. G , Panasenkov S. Yu , Griror’ev E. G
Published: October 2020

Correction of posttraumatic deformity and stabilization of injured segment play an important role in treatment and complication prevention after traumatic compression vertebral body fractures. Possibilities of deformity reduction using vertebroplasty and a combination of distractive titanium cage with insertion of bone cement into vertebral body (stenoplasty) are not well studied. Retrospective comparative analysis of clinical efficacy and degree of kyphotic deformity reduction using puncture vertebroplasty (1 st group, n=15) and stenoplasty (2 nd group, n=15) in patients with traumatic A1 compression fractures of thoraco-lumbar vertebral bodies was performed. Severity of pain syndrome (VAS) and degree of injured segment deformity (kyphotic angle and wedge-shaping index) were assessed. In both groups surgical intervention resulted in marked pain reduction but in long-term period it was less significant for 2 nd group (p=0.0035). Postoperatively kyphotic angle median and wedge-shaping index changed statistically significant in 2 nd group from 12.60 (10.50; 13.40) to 2.50 (1.90; 3.20) (p=0.0015) and from 25.3% (22.8; 26.7) to 9.3% (8.9; 11.4) (p=0.0022), respectively and not significantly in 1 st group from 13.10 (11.40; 14.30) to 12.90 (11.20; 14.00) (p= 0.93) and from 26.5% (24.0; 28.8) to 25.9% (23.8; 28.4) (p=0.86), respectively. Progression of posttraumatic kyphosis in late postoperative period was noted in 1 st group (P M Ü=0.042) but not in 2nd group (P =0.58). In traumatic A1 compression fractures stenoplasty enabled to perform kyphotic deformity correction in the early period of spinal injury, to achieve significantly greater reduction of kyphotic angle and to preserve the result in remote postoperative period as compared to puncture vertebroplasty
Congenital Hip Deformity Morbidity in Children of Russia Based on Official Statistic Data 2011-2013
Authors: Es’kin N. A , Andreeva T. M
Published: October 2020

Congenital hip deformity morbidity in children was studied on the basis of official statistic data in the period 2011-2013. It was detected that total and primary morbidity was characterized by wide ranging values with significant year after year changes, great value discrepancy between urban and rural population. For early diagnosis and treatment of pathology the elaboration and application of screening program for detection of pathologic changes in the hip during first months of life, the standards for treatment of patients with congenital hip deformity and protocols for management of patients depending on severity of pathological changes were proposed.
Pathohistologic Changes in Hip Tissues and Clinical-Morphologic Correlations in Diseases Complicated by Femoroacetabular Impingement Syndrome
Authors: Grigorovskiy V. V , Filipchuk V. V , Kabatsiy M. S
Published: October 2020

The purpose of the work was to detect clinical-morphologic correlative dependences in patients with clinically marked femoroacetabular impingement (FAI) syndrome basing on the study of pathomorphologic changes in hip joint tissues, semiquantitative quantification of pathologic changes intensity, frequency analysis of their occurrence in nosologic groups of comparison. Study was performed on specimens of hip joint tissues - femoral head, acetabulum, acetabular labrum and joint capsule, resected during indicated corrective surgeries for femoral head aseptic necrosis and juvenile epiphysiolysis. Clinical-morphologic study revealed various pathologic changes: dystrophic-destructive, ischemic-necrotic and productive-inflammatory. In patients with FAI syndrome clinical and morphologic correlative dependences varied by absolute value, sign and degree of reliability of association coefficient parameters, i.e. groups of patients with certain nosologic units retained the peculiarities of rate and characteristics proportions in correlative dependences
Method to Analyze the Complications in Traumatology and Orthopaedics Based on the Form of Recording the Conformity of Fragment Biomechanical Characteristics with Fixator Arrangement
Authors: Kesyan G. A , AV Zhadin Valer'evich , AV Tsiskarishvili V , Kuz’menkov K. A
Published: October 2020

The most common mistake resulting in the development of pseudarthrosis and suppuration is inadequate choice of metal construction that prevents from performing biochemically substantiated osteosynthesis. A form for recording the conformity of bone fragment biomechanical characteristics with fixator arrangement that enables to plan surgical intervention as well as to perform retrospective analysis of osteosynthesis quality regardless of the type of chosen metal construction.
Experience in Transosseous Arthroscopic Restoration of Shoulder Rotator Cuff
Authors: Lomtatidze E. Sh , Kubashev A. A , Belyak E. A , Lazko F. L , Prizov A. P
Published: October 2020

Results of arthroscopic treatment for 10 patients (10 shoulder joints) with rotator cuff rupture using transosseous suture are presented. Mean age of patients made up 49 (38-63) years. In 2 cases the size of defect was under 1 cm, in 6 cases - 1-3 cm, in 2 cases - 3-5 cm. Mean score by UCLA scale was 13 (8-14) preoperatively and 26 (24-28) in 3 months after intervention. Advantages of the described technique include rapidity of performance, low price and provision of anatomic restoration of injured structures.
New Method for 3D-Testing of Spinal Stabilizer Muscles
Authors: Mironov S. P , Tsykunov M. B
Published: October 2020

Data on testing of spinal stabilizer muscles using isokinetic dynamometer are presented. It is shown that achieved test results enable to detect muscular imbalance even at subclinical level and to elaborate individual rehabilitation programs.
Method for Quantitative Evaluation of Spiral Tibial Fractures
Authors: Matsukatov F. A , Martel’ I. I
Published: October 2020

To elaborate a method of quantitative evaluation of instable spiral tibial bones fractures as the basis for differential approach to secondary displacement prevention, x-rays of 312 patients were analyzed and a series of experiments to study spiral fractures peculiarities was performed. The factors responsible for the instable pattern of spiral tibial fractures were detected. Quantitative index of the risk of secondary displacement was calculated and preventive measures were elaborated on their basis. Proposed recommendations on secondary displacement prevention were used as a basis for the treatment of 83 patients using Matsukidis - Shevtsov apparatus. Long-term treatment results were studied in 59 (71%) patients. Excellent and good results were achieved in 51 (86.5%) and 8 (13.5%) patients, respectively. Neither satisfactory nor poor results were observed.
Intramedullary Osteosynthesis by Fixion System at Treatment of Long Bones Diaphyseal Fractures
Authors: Yamkovoi A. D , Zorya V. I
Published: October 2020

Treatment results for 61 patients with diaphyseal fractures of long bones of the extremities are presented. Fractures of the humerus were diagnosed in18 (29.5%) patients, femur - in 22 (36.1%) and tibia - in 21 (34.4%) patients. In most cases fractures of A1, A2, A3 and B1 were observed. For osteosynthesis blocking and non-blocking Fixion intramedullary nails were used. Long-term results (1 - 1.5 years) were analyzed for 42 patients and showed excellent and good results in 93% of patients. Nonunion and deformity was observed in 7% of observations. The advantages of the technique included low traumatization, short duration of surgical intervention, minimum (up to 200 ml) blood loss.
Direct Causes of Death in Road Traffic Accident Victims and Evaluation of the Efficacy of Three-Level Trauma Centers Activity in Chelyabinsk Region
Authors: Moskvichyova M. G , Shishkin E. V
Published: October 2020

Data on direct causes of death in road traffic accident (RTA) victims for Chelyabinsk region is presented for 2 periods, i.e. before (2008-2010) and after (2011-2013) organization of trauma center. Comparison of the level and structure of RTA death causes in two three-year periods showed no significant differences. Evaluation of the efficacy of trauma centers activity (2011 - 2013) that render medical care to RTA victims with multiple and concomitant injuries is performed. During three-year period of trauma centers activity the number of road traffic deaths resulted from multiple and concomitant injuries increased by 17.22%. No statistically significant changes in the rate of three main causes of RTA related death (multiple and concomitant injuries, head and chest injuries) were noted during the study period. Achieved results confirm the necessity to elaborate and introduce the monitoring that will enable to evaluate the efficacy and quality of trauma centers activity at all steps of medical care rendering including patients’ transportation.
Reparative Bone Regeneration at Use of Local Antibacterial Carriers in Purulent Osteomyelitis (Experimental Study)
Authors: Erofeev S. A , Reznik L. B , Dzyuba G. F , Odarchenko D. I
Published: October 2020

Efficacy of reinforcing local antibacterial carriers use upon the degree and terms of reparative regeneration of bone tissue defects resulted from osteomyelitis process was assessed in animal experiment (36 rabbits). In study group ( n =18) surgical treatment consisted of osteomyelitis focus salvage resection and installation of reinforcing local antibacterial carrier based on polymethyl methacrylate. In control group ( n =18) radical resection of the osteomyelitis focus with adjacent soft tissue structures was performed. In study group growth of microorganisms was not detected already on 28 th postoperative day while in control group the complete depression of pathogenic microflora was achieved only by day 50. Roentgenologic and morphologic data showed marked reparative regeneration in the zone of defect with formation of functionally mature callus under the effect of antibacterial carrier at terms up to 16 weeks.
Analysis of Orthopaedic Sequelae of Special Treatment of Malignant Tumors in Children
Authors: Petrichenko A. V , Bukreeva E. A , Korneeva A. V , Shavyrin I. A , Ochkurenko A. A , Kolesov S. V , Sharoev T. A , Ivanova N. M
Published: October 2020

Ninety five patients (mean age 13.72±4.2) with complaints on loco-motor system disorders after special treatment for malignant tumors were under observation of orthopaedic surgeon. The most common sequelae of treatment were muscular hypotrophy (66 children), I-III degree scoliosis (75), rigidity (61), bone metabolism disorder and osteopenia (47), one limb shortening even in presence of “growing” endoprosthesis (46). Individual rehabilitation course was performed in 43 (45.3%) children and resulted in increase of joint movement range, improvement of posture, and increase in muscular tension. Timely performed complex of rehabilitation measures enabled to correct sequelae of special treatment at early terms that significantly decreased disability of children, increases their social adaptation and quality of life.
Experience in Arthroscopic Treatment of Massive Rotator Cuff Injuries in Elderly Patients
Authors: Kubashev A. A , Lazko F. L , Belyak E. A , Prizov A. P , Lomtatidze E. Sh
Published: October 2020

Arthroscopic treatment results for 6 elderly patients (mean age 64 years) with massive (over 5 cm) nonreconstructable rotator cuff tear are presented. In all cases fatty degeneration of the rotator cuff tendon above 3 rd degree by Goutallier classification was present. In all patients elbow arthroscopy with implantation of InSpace Balloon into subacromial space was performed. Mean score by UCLA scale made up 14 (12-15) preoperatively and over 30 in 6 months after intervention that corresponded to a good and excellent result. Preliminary results indicate that applied technique is a simple, mini-invasive and effective intervention enabling to reduce pain and increase range of movements in this group of patients.
Prospects for Local Application of Antiresorptive Drugs in Skeleton Bone Injuries and Diseases
Authors: Rodionova S. S , Lekishvili M. V , Sklyanchuk E. D , Torgashin A. N , Ryabov A. Yu , Yurasova Yu. B
Published: October 2020

Increase in bone tissue resorption intensity on the border “metal - bone” as a compulsory component of remodeling in systemic osteoporosis or other metabolic osteopathies may result in poor surgical treatment results. Present review is dedicated to the analysis of available data on the possibility of local bisphosphonates application for the depression of resorption process in the zone of surgical intervention. In some works it is noted that just the local use of bisphosphonates is more effective for the normalization of remodeling and provision of biologic stability of the implants.
Repair of Partial Thickness Articular Hyaline Cartilage Injuries with Multipotent Mesenchymal Stromal Bone Marrow Cells Transplantation in Rabbits
Authors: Chailakhyan R. K , Shekhter A. B , Tel’pukhov V. I , Ivannikov S. V , Gerasimov Yu. V , Vorobieva N. N , Moskvina I. L , Bagratashvili V. N
Published: October 2020

Possibility of hyaline cartilage integrity restoration using multipotent mesenchymal stromal cells (MMSC) was studied on the rabbit model of partial thickness articular hyaline cartilage defect without subchondral plate damage. Size of defect made up 0.5 cm in diameter and 1.5 mm deep. Autologous bone marrow was harvested from the resected upper flaring portion of the ilium, single cell suspension was prepared and cultured in matrasses. Grown MMSC were centrifuged and the sediment was transferred into the cartilage defect. The cells were covered with either vicryl or gelatin sponge, or vicryl mesh. Histologic examination was performed in 4 months. It was shown that the most active regeneration of hyaline cartilage tissue, that substituted the largest part of a defect, was noted when MMSC were covered with vicryl mesh. One of the advantages of vicryl mesh use was that it neither protruded above the cartilaginous plate nor compressed the cells, and slowly resolved.
Efficacy of Gen-Activated Osteoplastic Material Based on Octacalcium Phosphate and Plasmid DNA containing vegf Gene for Critical-sized Bone Defects Substitution
Authors: Bozo I. Ya , Deev R. V , Drobyshev A. Yu , Komlev V. S , Rozhkov S. I , Eryomin I. I , Dalgatov I. G , Volozhin G. A , Grachyov V. I , Fedotov A. Yu , Isaev A. A
Published: October 2020

Gene-activated osteoplastic materials are a principally new class of medical devices for bone plasty. The purpose of the study was to evaluate the biological action of the material based on octacalcium phosphate and plasmid DNA containing vascular endothelial growth factor (VEGF) gene. Study material was implanted into 10 mm diameter rabbit parietal bone defects. Formation of bone regenerates around material granules even in the center of the defect and the presence of bone marrow in intertrabecular space on day 60 after implantation was detected. In control group of animals - implantation of carrier without gene constructions - regeneration took place mainly on the bone defect margins. Use of gene-activated osteoplastic material resulted in pronounced osteoinduction that provided both acceleration of the regeneration and increase of new bone tissue formation intensity.
Hip Reconstruction with Demineralized Allografts in Revision Arthroplasty
Authors: Chekanov A. S , Voloshin V. P , Lekishvili M. V , Ochkurenko A. A , Martynenko D. V
Published: October 2020

Long term results of revision arthroplasty with hip joint reconstruction using demineralized allograft based on cranial vault flat bones are presented. Since 2005 nine patients (14 substitutions) aged from 46 to 67 years were operated on. Control of implanted material remodeling was performed in 12 months after surgery and then annually up to 8 years. No one case of implanted material suppuration was observed. Roentgenologic control showed relatively early remodeling of allografts in 1.5-2 years after intervention. Remodeling process was characterized by the increase of roentgenologic density in plasty site. Positive results were achieved 8 patients (13 substitutions) that made up 93%.
On the Safety of Osteoplastic Materials
Authors: Volkov A. V
Published: October 2020

Experimental and clinical studies of osteoplastic materials of various groups were performed. IT was shown that implantation of osteoplastic materials stipulated the development of chronic productive inflammation by the type of foreign body response while the process of bone formation in the regenerate containing osteoplastic material entailed resorption of newly formed bone tissue on its surface. Analysis of the reasons of low biocompatibility of the materials was performed and scheme for osteoplastic material safety and efficacy study planning was proposed.
Magnetic Resonance Imaging of the Whole Body (DWIBS). Potentialities and Perspectives for Application in Bone Pathology
Authors: Morozov A. K , Makhson A. N , Karpov I. N
Published: October 2020

The purpose of the study was to determine the role and place of whole body MRI with DWIBS in diagnosis of human loco-motor system oncologic pathology. Two hundred fifty six patients with presumptive diagnosis of oncologic disease were examined. Obtained signal was evaluated by true signal intensity scale in minimal examination volume (voxel), either drawn through the volumetric lesion or in an isolated area of arbitrary shape. Study results were verified using standard MRI protocols (T1, T2, STIR), contrast enhancement, MSCT, radionuclide and morphologic examination. High sensitivity of the technique to pathologically changed tissues with reduced water diffusion coefficient was demonstrated. Magnetic resonance diffusion-weighted whole-body imaging with DWIBS may be recommended as noninvasive screening technique for the diagnosis of both primary and secondary (metastases) oncologic process.
Comparative Evaluation of the Results of Surgical and Conservative Treatment of Planovalgus Foot Deformity in Children
Authors: Kozhevnikov O. V , Kosov I. S , Ivanov A. V , Gribova I. V , Bolotov A. V
Published: October 2020

Comparative evaluation of treatment results was performed for 122 patients, aged 1.5 - 18 years, with planovalgus foot deformity. Complex treatment included surgical intervention (modification of foot reconstruction by Kummer-Kouel-Ramsey, subtalar joint arthroereisis and two step combined technique) in combination with the method of functional biomanagment. Results were assessed at terms from 6 months to 4 years basing on the data of objective instrumental examinations (computed podography, roentgenography, electromyography) and the data on the international AOFAS system. It was stated that conservative treatment ensured stabilization of the condition and increase of mean point by AOFAS scale made up 5.82. In the same time complex treatment contributed to the restoration of osteoarticular interrelation and ensured functional competence. Mean estimate by AOFAS scale increased by 29.48 pointsin that group of patients. Positive results of complex anatomo-functional approach to the treatment of children withplanovalgus deformity enable to consider the proposed technique as a prospective one.
Potentialities of Minimally Invasive Osteosynthesis in Treatment of Malleolus Fractures
Authors: Solod E. I , Lazarev A. F , Ermolaev E. G
Published: October 2020

Treatment results for 71 patients with malleolus fractures are presented. In 32 patients (comparative group) surgery was performed by AO/ASIF technique after edema resolution. Thirty nine patients from the main group were operated on by our minimally invasive technique using V-shaped pins and threaded pins on the next day after admission independently on the presence of edema in the ankle joint region. All patients were operated on at terms from 1 to 3 weeks after injury. Duration of hospitalization averaged 16 and 10 days, restoration of joint function made up 6 and 2 weeks for the patients from the comparative and main group, respectively. Complications were observed only in patients from the comparative group, i.e. marginal skin necrosis in 8 (25%), inflammatory complications in 5 (15.6%), metal fixator migration in 1 (3.1%) and fracture nonunion in 4 (12.5%) patients. Outcomes were assessed by AOFAS Ankle- Hindfoot Scale. Mean point made up 90.3 in the main group and 88.6 in the comparative jnt. In the experimental part of the study the strength (tensile and shear) of 3 types of osteosynthesis for medial malleolus fracture were compared: with either 2 cannulated screws, V-shaped pin or 2 biodegradable screws of glycolized lactic acid was compared. Although the osteosynthesis of medial malleolus with V-shaped pin was the least strong it met the requirements of internal osteosynthesis.
Modeling of a Different Volume Spinal Cord Injury in Rats and Methods for Evaluation of Lost Functions Restoration
Authors: Mironov S. P , Kolesov S. V , Stepanov G. A , Sazhnev M. L , Gubin S. P , Ionin Yu. V , Motin V. G , Panteleev A. A
Published: October 2020

The method for modelling of a different volume spinal cord injury to study potentialities for its regeneration is presented. The work was performed on 80 laboratory rats divided into 5 groups according to the volume of inflicted injury. Original instrument with restrictors for the infliction of the accurate and measured by volume spinal cord injuries was elaborated. The degree of function restoration was evaluated by the results of visual assessment of the movements in animals’ hind paws, records of induced potentials of the cerebral cortex region and by BBB scale. In every separate group the obtained indices were distributed uniformly that indicated justifiability and reproducibility of the elaborated model of incomplete spinal cord injury.
Surgical Treatment of Severe Forefoot Deformity
Authors: Usol’tsev I. V , Leonova S. N , Kosareva M. A
Published: October 2020

Treatment results of 61 years old patient with severe forefoot deformity - right-side transverse-longitudinal stage II platypodia: right-side II-III degree deforming arthrosis of 1st metatarsophalangeal joint, hallus valgus with subluxation, combined 1st metatarsophalangeal joint contracture, pain syndrome, are presented. Surgical treatment included operation by Schede, lateral release of 1stmetatarsophalangeal joint, SCARF osteotomy of 1st metatarsal bone, Akin osteotomy of proximal hallux phalanx and tenoplasty of dorsal hallux flexor. As a result correction of right forefoot deformity was achieved, pain syndrome was arrested and weight bearing ability of the right foot was restored.
Efficacy of Zoledronic Acid in Patients with Systemic Osteoporosis and Problem of «Non Respondents» to the Treatment
Authors: Rodionova S. S , Buklemishev Yu. V
Published: October 2020

Prospective study of zolendronic acid efficacy was performed in 112 patients with systemic osteoporosis. Study results confirmed the presence of patients who did not response to the treatment: in 15.7 % of observations reduction of mineral bone density (BMD) continued to progress. No significant differences in initial deviations of resorption and bone formation markers, peculiarities of calcium homeostasis were detected in “non respondents”. At the same time by the 12th month after treatment initiation the relationship between BMD increase with preservation of marked decrease of resorption marker (deoxypyridinoline) and bone formation marker (osteocalcin) was noted, that pointed out the expediency of prognostic model creation. Evaluation of the influence of certain risk factors (age, results of blood and urine biochemical tests, data of densitometry including the results of femoral neck BMD in some patients) using discriminant analysis showed that 81.5% of patients were correctly referred to the groups of patients who responded and not responded to treatment. Out of all initially studied parameters the most significant were 7 that in 78.6% of cases (method sensitivity) enabled to identify the patients with negative treatment effect and in 82.1% of cases (method specificity) - with positive treatment effect.
Biologic Characteristics of Bone Substituting Tissue Engineering Construction Based on Calcium Phosphate Ceramics, Autologous Mesenchymal Stromal Cells and Fibrin Hydrogel
Authors: Mamonov V. E , Chemis A. G , Komlev V. S , Berkovskiy A. L , Golubev E. M , Proskurina N. V , Sats N. V , Drize N. I
Published: October 2020

Biological characteristics of bone substituting tissue engineering construction (TEC) that contained porous calcium phosphate ceramic granulate (CPC) of phase structure ((tricalcium phosphate (TCP)), fibrin hydrogel and autologous multipotent mesenchymal stromal cells (auto-MMSC) induced and non-induced to osteogenic differentiation were studied in vivo. The following characteristics of TEC were determined: ability to transfer within its structure the viable auto-MMSC with preservation of their regeneration potential; ability to osteogenesis only under conditions of orthotopic implantation; ability of induced to osteogenic differentiation auto-MMSC to participate in the reparative processes for not more than within 6 weeks after implantation; negative affect of fibrin hydrogel on the osteoinductive properties of CPC within TCP structure. It was shown that to provide osteogenesis in the implanted TEC not only the viable auto-MMSC but simultaneous presence of osteoinductive and osteoconductive factors was required. No bone formation in a critical bone defect and in ectopic implantation takes place without observance of these conditions.
Modeling of a Different Volume Spinal Cord Injury in Rats and Methods for Evaluation of Lost Functions Restoration (part 2)
Authors: Mironov S. P , Kolesov S. V , Stepanov G. A , Sazhnev M. L , Gubin S. P , Ioni Yu. V , Motin V. G , Panteleev A. A
Published: October 2020

The purpose of the study was to work out the methods for somatosensory evoked potentials registration under conditions of nerve paths injury in experiment. Evoked potentials were recorded in laboratory animals divided into 5 groups according to the volume of injury inflicted by the technique worked through previously. Potentials were recorded prior to intervention and on 1st, 7th, 14th, 21st, 30th and 45th postoperative day. On the 1st day sharp decrease of potential amplitudes was observed in groups with incomplete spinal cord injury. In groups with complete spinal cord injury no potentials were recorded. Slight restoration of nerve conductivity was observed only in rats with 50% spinal cord transection. Study results showed the efficacy of the technique in the assessment of spinal cord tissues conductivity and confirmed the absence of spontaneous nerve paths restoration after more than 50% of spinal cord transection.
Student Years of N.N. Priorov (in commemoration of the 130th anniversary of birth)
Authors: Baitinger V. F , Kurochkina O. S , Delich I. B
Published: October 2020

Student years of the Honoured Science Worker of RSFSR, Academician of the Academy of Medical Sciences (AMS), Soviet trauma- and orthopaedic surgeon, the founder of the Central Institute of Traumatology and Orthopaedics N.N. Priorov are presented. The atmosphere of student life with its everyday troubles, living conditions, university studies, lack of money, unemployment, revolutionary sentiments and yearning of young people for knowledge as well as the desire of teachers to share their experience to young generation is shown.
Study on pyrexia in pregnancy and labour with special emphasis on fetomaternal outcome
Authors: Sultan Shabana , Parihar Reena , Badkur Poorva
Published: October 2020

Background: Pyrexia in pregnancy is a very common clinical problem worldwide. Fever during pregnancy causes significant maternal and fetal complications. Fetus being an integral part of the feto-maternal unit and pregnancy involving numerous physiological changes and adaptations, pyrexia during the pregnancy affects both the mother and her foetus adversely. Effect of pyrexia on pregnancy depends on the extent of the rise in the temperature.Methods: This is a prospective observational hospital-based study conducted over a period of 1 year from march 2018 to February 2019 Department of Obstetrics and Gynaecology, Sultania Zanana Hospital, Gandhi Medical College, Bhopal.Results: Total no. of antenatal admission in Hospital during study period were 15354. Total 306 cases of pyrexia in pregnancy were found during the study period. Incidence of pyrexia in pregnancy in our study during study period was found 2%.Conclusions: The present study has demonstrated a need for multidisciplinary approach in cases of pregnancy complicated with pyrexia and also higher risk of maternal morbidity and mortality in un-booked patients. We found that pregnancy outcomes were good in booked cases with regular checkup. Early detection and management of patients with pyrexia can certainly help to improve maternal and fetal outcome. This also shows that multidisciplinary approach should extent throughout antenatal, intra-partum and postpartum period.
Acute necrotizing encephalopathy of childhood: an under-recognized and diverse clinico-radiological syndrome
Authors: Vanaki Raghavendra Narayan , Diwanmal Suchitra Basappa , Rajesh Pol Ramesh , Yelamali Bhuvaneshwari Chandrashekhar , Kulkarni Milind Ramakant , Brahmandbher Sudheendraswamy Veerannayya
Published: October 2020

Background: With advances in neuroimaging, acute necrotizing encephalopathy of childhood (ANEC) is being recognized as an acute encephalopathy with a characteristic rapidly deteriorating neurological course with poor neuro-developmental outcomes with high mortality and morbidity rates. Indian data of ANEC is primitive and hence this study was planned. The objective of the study was to evaluate the clinical, radiological characteristics and its outcomes in children with ANEC.Methods: Retrospective review of 10 infants and children with ANEC at Department of Paediatrics, S.N. Medical College and HSK Hospital, Bagalkot from January 2013 to December 2019. ANEC was suspected based on clinical and radiological characteristics and diagnosis was made based on diagnostic criteria proposed by Mizuguchi et al. Clinical and radiological (Magnetic resonance imaging (MRI) brain characteristics) findings and response to early pulse dose steroid therapy and supportive treatment were assessed in all cases. All cases were followed for evaluation of neurodevelopmental outcome and response to physiotherapy was noted in all the cases.Results: Total 10 cases were analysed (age ranged from 6 months to 11 years). Sex distribution male to female was 3:7. All cases had precedent viral illnesses and had fever, coryza, diarrhoea. The initial neurological symptoms included seizures and status epilepticus (n=7), altered sensorium (n=3), focal neurological signs , gait disturbances (n=2) and diplopia (n=1). MRI brain revealed characteristic thalamus involvement with varied involvement of midbrain, pons, medulla (n=10). Other findings were cavitation (n=5), haemorrhage (n=4), minimal residual lesions (n=4), cerebral atrophy (n=1), normal brain study (n=5) on follow-up. 9 out of 10 cases survived, responded to early physiotherapy and rehabilitation. 6 children had complete recovery with minimal disability in 3 cases.Conclusions: ANEC is a clinico-radiological syndrome. Early detection and appropriate treatment improves outcome in ANEC.
Особенности стратегий и тактик проектирования в музыкальном образовании
Authors: Константинова Наталья Владимировна
Published: October 2020

Проектировочная деятельность становится необходимым компонентом подготовки современного педагога-музыканта. Развитие педагогической науки и практики, появление новых технологий создаёт необходимость постоянного переосмысления возможностей проектировочной деятельности, что недостаточно освещено в научно-педагогической литературе. Целью работы стало рассмотрение системы музыкального образования, как целостного компонентапроектирования, а также музыкально-педагогического процесса, как его части с позиций взаимодействие трёх субъектов: учитель – музыка – ученик. Дано пояснение содержания каждого. Изучен опыт проектирования системы музыкального образования на примере анализа проекта «Музыка для всех» в Республике Саха (Якутия). Представлен анализ педагогической ситуации, имеющей эстетический характер, как основного объекта тактики проектирования, её содержания, структуры, этапов организации в музыкально-педагогическом процессе. Определены формы проектирования в музыкально-образовательной практике. Приведены условия создания благоприятной педагогической среды в реализации проектной деятельности педагога-музыканта. Изложенные позиции позволят ориентироваться и адаптироваться к постоянно развивающимся и меняющимся педагогическим знаниям, ускорят адаптацию к новым музыкально-образовательным технологиям, новым парадигмам образования. Научным вкладом данной работы стало обоснование проектирования с позиций специфики взаимодействия учитель – музыка – ученик.
Synthesis and Characterization of a Novel Niosome System Containing Adiantum Capillus-Veneris for Breast Cancer Therapy
Authors: Ansari Mojtaba , Hasani Sanaz
Published: October 2020

Background: Due to the increase in cancer and side effects of common therapies, researchers are looking for treatments with the least side effects, which is why medicinal plants have become so important. Adiantum capillus-veneris L. plant commonly called southern maidenhair fern, and also named as “Pare-siavashan” in medical and pharmaceutical textbooks of Iranian Traditional Medicine, contains triterpenoid compounds that have anti-tumor properties. It is a perennial fern with narrow stems and small leaves that grows in hot and humid places. This study aims to make biocompatible nanosystems carrying Adiantum capillus-veneris extract with an appropriate loading rate and to compare the anti-tumor properties of the extract-carrying system with its free state.
Materials and Methods: After Extracting by Soxhlet, the resulting extract was loaded in the nano-niosome system by thin-film method and was subjected to physical, chemical, and cellular characterization.
Results: The results of this study showed that the loading rate of Adiantum capillus-veneris extract in niosomic formulation is 50.74% and the resulting particles are spherical with a size of 325.7nm and anionic. No chemical interactions were found between niosome and extract and the resulting system was chemically stable.
Conclusion: Based on acquired results, the designed system has acceptable anti-cancer properties on MCF7 cell line. It is notable that the cell survival rate was about 19 %.
An Update of Pharmacological and Non-pharmacological Therapies for COVID-19 Pandemic Trivia
Authors: Goswami Shamabaditya , Pal Nikita , Nath Mishra Kushal , Singh Prashant , Chegini Zahra , Pal Singh Ravindra
Published: October 2020

Background: The whole planet is facing one of the scariest pandemic situations in this era. On 11th February, 2020 the World Health Organization announced the name of an unknown disease as COVID-19, which is caused by the ssRNA virus SARS-CoV-2 (formally recognized as a sister of SARS-CoV and MERS-CoV). The epicenter of this disease is Wuhan, Hubei Province, China. COVID-19 can affect all age groups, but particularly affects immune compromised and aged persons with co-morbid conditions. It is highly contagious disease that involves mild to severe respiratory symptoms along with breathing difficulties.
 Objectives: As SARS-CoV-2 is a new strain of β-coronavirus that spreads from animals to humans via an unknown intermediate host, no vaccines have been developed yet and only supportive treatment is given to the infected patients. The review paper highlights the pharmacological therapy as a supportive treatment given to the COVID-19 patients and non-pharmacological therapeutic approaches for the prevention.
Methods: Methods: Authors were surveyed and reviewed numerous articles, magazines, news papers, conference proceedings from different search engines and made the review successful.
Results: Some drugs of different categories are approved and prescribed to the patients and some others are still under investigation and have gone through clinical trials.
Conclusion: As no specific treatment or drugs for this disease have been developed till the date; therefore, social distancing, home quarantine, and proper healthy lifestyle management are the best current short-term options to avoid further spread of this pervasive virus.
Chloroquine Phosphate Metabolism and Gender-based Phenotypic Analysis in Healthy Subjects’ Urine Following Oral Administration
Authors: J. Bunu Samuel , Vaikosen Edebi N. , Nnadozie Kosi W.
Published: October 2020

Background: Chloroquine, 4-N-(7-chloroquinolin-4-yl)-1-N,-N-diethylpentane-1,4-diamine has promising activity against corona virus disease 2019 (COVID-19) and as such, it is imperative to thoroughly understand and determine the rate at which individual body systems metabolizes the drug. Chloroquine a known antimalarial drug belongs to the chemical class of 4-aminoquinolines.
Objectives: The study aimed to analyze Chloroquine and its metabolite in biological fluids of healthy subjects by simple thin layer chromatography (TLC), which is an efficient, and inexpensive method for quantifying Chloroquine and its metabolites.
Methods: A total of 30 healthy volunteers participated in the study by ingesting 500 mg of chloroquine, and the results were compared with side effects experienced by these subjects. Two brands of Chloroquine phosphate were used for the analysis and the urine were collected pre and post-drug administration and the intensities of the spots observed were compared with the reference standard stock solution. The same or greater intensity of sample spot indicates poor metabolizer, less intensity when compared to the stock spot indicates intermediate metabolizer while a much lesser intensity indicates an extensive metabolizer.
Results: There was a statistically significant difference between the brands of chloroquine used at P<0.05. 30% of the volunteers were assigned poor metabolizer phenotype, 50% were assigned extensive metabolizer phenotype, and 20% assigned Intermediate metabolizer phenotype based on the intensity of spots observed. The majority of the poor metabolizers were females while the majority of the extensive metabolizers were males.
Conclusion: Gender differences plays a vital the role in metabolism, therefore outine implementation of phenotype determination before therapy will therefore greatly improve the goal of therapy and quality of life. implementation of phenotype determination before therapy will, therefore, greatly improve the goal of therapy and quality of life.
Clinical impact of a pharmacist-led medication review with follow up for aged polypharmacy patients: A cluster randomized controlled trial
Authors: Varas-Doval Raquel , Gastelurrutia Miguel A. , Benrimoj Shalom I. , García-Cárdenas Victoria , Sáez-Benito Loreto , Martinez-Martínez Fernando
Published: October 2020

Background: Medication review with follow-up (MRF) is a service where community pharmacists undertake a medication review with monthly follow-up to provide continuing care. The ConSIGUE Program assessed the impact and implementation of MRF for aged polypharmacy patients in Spanish Community Pharmacies. The present paper reports on the clinical impact evaluation phase of ConSIGUE.

Objective: The main objective of the study was to measure the effect of MRF on the primary outcome of the number of uncontrolled health problems. Secondary objectives were to analyze the drug-related problems (DRPs) identified as potential causes of ineffective or unsafe medications and the pharmacists’ interventions implemented during MRF provision.

Methods: An open-label multi-centered cluster randomized study with comparison group (CG) was carried out in community pharmacies from 4 provinces in Spain during 6 months. The main inclusion criteria were patients over 64 years old, using 5 or more medicines. The intervention group (IG) received the MRF service (advanced medication review-type 3 MR) whereas patients in the CG received usual care.

Results: 178 pharmacies recruited 1403 patients (IG= 688 patients; CG= 715 patients). During the 6 months of the study 72 patients were lost to follow up. The adjusted multi-level random effects models showed a significant reduction in the number of uncontrolled health problems over the periods in the IG (-0.72, 95% CI: -0.80, -0.65) and no change in the CG (-0.03, 95%CI: -0.10, 0.04). Main DRPs identified as potential causes of failures of uncontrolled health problems’ treatment were undertreated condition (559 DRPs; 35.81%), lack of treatment adherence (261 DRP; 16.67%) and risk of adverse effects (207 DRPs; 13.53%). Interventions performed by pharmacist to solve DRP mainly included the addition (246 interventions; 14.67%) and change (330 interventions; 19.68%) of a medicine and educational interventions on medicine adherence (231 interventions; 13.78%) and non-pharmacological interventions (369 interventions; 22.01%).

Conclusions: This study provides evidence of the impact of community pharmacist on clinical outcomes for aged patients. It suggests that the provision of an MRF in collaboration with general medical practitioners and patients contributes to the improvement of aged polypharmacy patients’ health status and reduces their problems related with the use of medicines.
Análise das competências do tutor a distância nos cursos de Gestão em Saúde no Brasil
Authors: Silva Ruann Oswaldo Carvalho da , Ditterich Rafael Gomes
Published: October 2020

Este trabalho analisou as exigências necessárias para atuar como tutor a distância nos cursos de especialização em Gestão em Saúde ofertado pelo Sistema Universidade Aberta do Brasil. O objetivo foi analisar exigências requeridas ao cargo de tutor a distância em editais de seleção. Por meio de uma análise documental foram analisados os editais de seleção de tutores a distância publicados entre os anos de 2013 e 2015. Essa pesquisa apresenta abordagem quantitativa do tipo descritiva e exploratória. Dentre as 23 Instituições de Ensino Superior que ofertam o curso, somente 65,1% foram localizados os editais de seleção de tutores. Na análise dos editais, 66,7% das instituições exigiam dos tutores formação na área de saúde. Quanto a experiência docente somente 46,7% apresentavam tal exigência. Quanto a experiência prévia em ensino a distância, somente 13,3% exigiam que o tutor deveria ter conhecimento e outros 13,3% valorizavam inicialmente ter experiência no Ensino à distância. Constatou-se que a maioria exigia as competências cognitivas em detrimento das funcionais, comportamentais, políticas e ética. Recomenda-se que as instituições de ensino avaliadas aperfeiçoem os processos seletivos de tutores.