bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of
TTN
Truncating Variants in >74 000 Cases Reveals New Clinically Relevant Gene Regions
Authors: Vatta Matteo , Regalado Ellen , Parfenov Michael , Swartzlander Dan , Nagl Andrea , Mannello Meghan , Lewis Rachel , Clemens Daniel , Garcia John , Ellsworth Rachel E. , Morales Ana , Ting Yi-Lee , Aradhya Swaroop
Published: February 2025

BACKGROUND:

Truncating variants (TTNtvs) in the titin (
TTN
) gene have been associated with cardiomyopathies or arrhythmias (C/A) and autosomal recessive neuromuscular diseases (NM). However, the clinical significance of TTNtvs across the entire coding sequence of
TTN
has not been comprehensively assessed. The purpose of this study was to examine the burden of TTNtvs in C/A and NM cases compared with controls in the genome aggregation database.

METHODS:

This was a retrospective study of probands who underwent multigene testing (49 740 C/A panel, 24 514 NM panel) that included
TTN
from November 2017 to October 2021. Burden testing was performed using controls in the genome aggregation database v3.1.2 database, and the analysis was stratified by exon/band location and exon usage in cardiac or skeletal muscle. Frequency and odds ratio of TTNtv alleles in C/A or NM cases and genome aggregation database controls were measured.

RESULTS:

There were 2446 (4.9%) C/A and 482 (2.0%) NM cases with 2446 and 528 TTNtv alleles, respectively. TTNtvs in all bands were significantly enriched in both C/A and NM cases compared with controls. A significant enrichment of TTNtvs in C/A was observed for exon 358 of the M-band (odds ratio, 2.55 [95% CI, 1.85–3.54]) but not the other M-band exons.

CONCLUSIONS:

In the largest single-site cohort of C/A and NM cases with TTNtvs, an enrichment of TTNtvs across
TTN
was observed. These findings expand the clinically relevant regions of
TTN
.
Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry
Authors: Park Tai Hwan , Hong Keun‐Sik , Cho Yong‐Jin , Ryu Wi‐Sun , Kim Dong‐Eog , Park Man‐Seok , Choi Kang‐Ho , Kim Joon‐Tae , Kang Jihoon , Kim Beom‐Joon , Han Moon‐Ku , Lee Jun , Cha Jae‐Kwan , Kim Dae‐Hyun , Kim Jae Guk , Lee Soo Joo , Kwon Jee‐Hyun , Kim Wook‐Joo , Shin Dong‐Ick , Yum Kyu Sun , Sohn Sung Il , Hong Jeong‐Ho , Choi Jay Chol , Lee Byung‐Chul , Yu Kyung‐Ho , Oh Mi‐Sun , Park Jong‐Moo , Kang Kyusik , Lee Kyungbok , Lee Sang‐Hwa , Jeong Hae‐Bong , Park Kwang‐Yeol , Lee Ji Sung , Lee Juneyoung , Gorelick Philip B. , Bae Hee‐Joon
Published: February 2025

Background

This study aims to evaluate temporal trends of advanced treatments and related clinical outcomes of ischemic stroke through a decade‐long trend analysis, using data from a comprehensive, national, multicenter registry. We also seek to identify areas in need of improvement.

Methods and Results

This analysis involved patients with ischemic stroke or transient ischemic attack registered prospectively in the CRCS‐K‐NIH (Clinical Research Center for Stroke in Korea–National Institute of Health) registry between 2011 and 2020. We examined temporal trends in risk factors, pathogenetic subtypes, acute management strategies, and outcomes for up to 1 year following a stroke. Generalized linear mixed models were used to account for center clustering. The average age of 77 662 patients increased 2.2 years in men and 2.4 years in women over the 10‐year follow‐up. Notably, in‐hospital neurological deterioration, 3‐month and 1‐year mortality rate, and cumulative incidence of recurrent stroke within 1‐year decreased over time after adjustments for age, sex, and initial stroke severity (
P
<0.01). However, functional outcomes at 3 months and 1 year remained unchanged. Endovascular thrombectomy increased from 5.4% in 2011 to 10.6% in 2020. Use of anticoagulants for atrial fibrillation, dual antiplatelet therapy, statins, and stroke unit care also increased. Contrarily, the rate of intravenous thrombolysis showed a slight decline.

Conclusions

This study points to a reduction in death and risk of recurrent stroke over the past decade, paralleling enhancement in acute and preventive stroke management. Nevertheless, the decline in the use of intravenous thrombolysis and the lack of improvement in functional outcomes following stroke are concerning trends that warrant thorough investigation.
Combination and Differentiation Theories of Categorization: A Comparison Using Participants’ Categorization Descriptions
Authors: Thomas Sujith , Kapoor Aditya , Srinivasan Narayanan
Published: February 2025

Differentiation and Combination theories make different predictions about the order in which information is processed during categorization. Differentiation theory posits that holistic processing of a stimulus occurs before individual features are processed. According to Differentiation theory, overall similarity-based categorization is faster and less effortful compared to unidimensional categorization. In contrast, Combination theory posits that individual features are processed first and that information regarding these features must be combined during multidimensional categorization. According to Combination theory, overall similarity-based categorization is more effortful and takes more time compared to unidimensional categorization. In this study, we trained participants to learn artificial categories using classification learning and observation learning procedures. We used participants’ categorization descriptions to determine the number of stimuli dimensions used for categorization. Our results from the first three experiments show that participants who used more dimensions took more time to categorize the transfer stimuli, consistent with Combination theory. In Experiment 4, we tested the hypothesis that using more dimensions takes more time solely due to multiple eye fixations and saccades. In our study, we used visual stimuli with features that do not overlap in space. Our results show that while performing a multidimensional task, participants need more time to recall the feature-category associations learned during the experiment, making the task more effortful, as predicted by Combination theory. Further studies are needed to determine whether Combination theory applies to other types of stimuli, particularly those with spatially non-separable features.
Pragmatics as Social Inference About Intentional Action
Authors: Bohn Manuel , Frank Michael C.
Published: February 2025

Pragmatic inferences are based on assumptions about how speakers communicate: speakers are taken to be cooperative and rational; they consider alternatives and make intentional choices to produce maximally informative utterances. In principle, this analysis applies to linguistic but also non-linguistic communicative actions, but this prediction is typically only tested in children and not in more systematic implicature contexts. We test key implications of this view across six online experiments with American English speaking adults (total N = 231). Experiments 1A and 1B showed that participants made pragmatic inferences based on different types of communicative actions, some being non-linguistic. In Experiment 2, pragmatic inferences were found to be conditional on the speaker’s epistemic states. Finally, Experiments 3A to 3C showed that pragmatic inferences were more likely to be made when the communicative action was produced intentionally. Taken together, these results strengthen the view that pragmatics includes social inference about cooperative communication over intentional actions, even non-linguistic actions.
On the valid name of Savigny’s „earthworm” Enterion terrestre (Crassiclitellata, Lumbricidae)
Authors: CSUZDI CSABA , SHERLOCK EMMA , SZEDERJESI TÍMEA
Published: February 2025

There are several long-standing nomenclatural problems within the family Lumbricidae (Bouché 1976, Sims 1983). Some have been successfully resolved recently (e.g. Nicolson & Csuzdi 2018; Popović et al. 2025) but there are a few that still need to be addressed and the name Enterion terrestre Savigny, 1826 is one of them.
A new species in the subgenus Wilhelmia (Diptera: Simuliidae: Simulium) from Sichuan, China
Authors: AN YUXIN , WANG YUYU
Published: February 2025

Simulium (Wilhelmia) xichangense sp. nov. is described based on females from Sichuan province, China. It is the firstly recorded species of the subgenus Wilhelmia in Sichuan province. This species is assigned to the subgenus Wilhelmia and is morphologically most similar to S. (W.) pinnatum Chen, Zhang and Jiang, 2016 from Gansu province in China. A key to the female adults of the subgenus Wilhelmia of China is provided.
A new species of Paraclimenes from New Zealand waters (Crustacea: Decapoda: Palaemonidae)
Authors: GRAVE SAMMY DE , FORMAN JEFF
Published: February 2025

A new species of the palaemonid genus Paraclimenes is described from relatively deep water in New Zealand. The new species can easily be distinguished from the only other two known species in the genus by the non-spatulate chela of the first pereiopod, the size of the uropods and the produced distal telson margin.
Two scale insect species (Hemiptera: Coccomorpha) associated with Chinese sweetgum in China, with description of a new species of Paraputo Laing, 1929 (Pseudococcidae)
Authors: LIU QING , TAN ZHIXIANG , XING JICHUN
Published: February 2025

A new species of mealybug (Hemiptera: Coccomorpha: Pseudococcidae), Paraputo liboensis Liu, Tan & Xing sp. nov., is described and illustrated from Guizhou Maolan National Nature Reserve, Guizhou Province, China. It was found together with Megalocryptes buteae Takahashi, 1942 (Coccomorpha: Coccidae) on a branch of Chinese sweetgum, Liquidambar formosana Hance (Altingiaceae), under carton shelters built by an ant, Crematogaster sp. (Hymenoptera: Formicidae: Myrmicinae). An updated key to the Paraputo species of China is provided.
To which degree do the details of stochastic perturbation schemes matter for convective-scale and mesoscale perturbation growth?
Authors: Chen I-Han , Berner Judith , Keil Christian , Thompson Gregory , Kuo Ying-Hwa , Craig George
Published: February 2025

This study compares the impacts of two stochastic parameterization schemes in a convective scale model. The implementation of the physically based stochastic boundary layer perturbation (PSP) scheme in the Weather Research and Forecasting (WRF) model represents uncertainties arising from unresolved boundary-layer processes due to the finite grid size. Uncertainty in the microphysical processes is represented by the stochastic parameter perturbation (SPPMP) scheme. We examine the regime dependence of the impacts with 48 h forecasts of days with weakly and strongly forced convection, as well as winter storms.

Early in the forecasts, the two stochastic parameterizations have different effects. The PSP scheme responds to boundary layer turbulence and produces strong perturbations that grow in phase with the diurnal cycle of convection. In regions with existing precipitation, SPPMP produces perturbations that grow more slowly with lead time, independent of the time of day. Perturbation growth in the PSP experiments is stronger for convective weather and can increase the total precipitation by triggering new convection, but SPPMP can dominate when precipitation occurs under stable conditions at night or in winter storms. The differences between the two schemes are relatively short-lived, and within a day of simulation, the amplitude and structure of differences introduced by both schemes are similar. This is found to be associated with saturation of perturbation growth on small scales (up to about 50 km). The locations and amplitudes of upscale perturbation growth appear to be determined by the larger-scale dynamics, independent of the details of the stochastic physics.
Renal Artery Vasculopathy: Case Study and Literature Review
Authors: Skeik Nedaa , Theeler Johanna , Wang Julia , Bae Aaron , Cho Mansoo , Manunga Jesse
Published: February 2025

Non-atherosclerotic renal artery vasculopathies are rare and can be caused by heterogenous group of diseases, some of which has bad prognosis. The literature addressing this rare group of disease is scarce. A single center analysis of all adult patients evaluated for renal artery disease including dissection, aneurysm, stenosis, vasculitis, thrombosis, irregularity, and renal infarct treated at our center, from January 2000 to April 2022. Baseline data collected included demographics, comorbidities, vital signs, laboratory values, pathology, genetic testing, and imaging results/diagnoses. Additionally, treatment modality, follow-up, and symptom relief/recurrence from follow-up visits were collected if available. Out of the included 227 patients, 91 (40%) had renal infarction, 70 (31%) had renal artery dissection, 69 (30%) had aneurysm, 33 (15%) had stenosis, and 32 (14%) had thrombosis. The most common diagnoses were fibromuscular dysplasia ( n = 86, 38%) and thromboembolism ( n = 38, 17%). Most patients improved with conservative management, reserving endovascular or surgical interventions for symptomatic patients with more complicated presentations. To our knowledge, this is the only case study and general review in the literature that addresses the diagnosis and management of non-atherosclerotic renal arteriopathies showing good outcome for most of the underlying etiologies.
Comparative Analysis of Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in Left Main Disease Stratification by Angiographic SYNTAX Score
Authors: Abohasan Abdulwali , Daoulah Amin , Elmahrouk Ahmed , Lotfi Amir , Haider Omar , Abozenah Mohammed , Elmahrouk Youssef , Iskandar Mina , Jamjoom Ahmed , Alshehri Mohammed , Abourehab Nadine , Ismail Mohamed Fouad , Elghaysha Ehab , Sabry Mohab , Yousif Nooraldaem , Almahmeed Wael , Hassan Taher , Nasim Naveen , Sayed Ahmed I. , Alhazmi Luai , Haider Kamel Hazaa , Abbadi Mosa Mohamma , Alfakih Shadwan Esmail Mohammed , Qutub Mohammed A. , Ghonim Ahmed A. , Dahdouh Ziad , Hashmani Shahrukh , Al Nasser Faisal Omar M. , Ajaz Ghani Mohamed , Shawky Abeer M. , Elganady Abdelmaksoud , Ibrahim Ahmed M. , Abualnaja Seraj , Fathey Hussien Adnan , Selim Ehab , Kazim Hameedullah M. , Abdulhabeeb Ibrahim A. M. , Balghith Mohammed , Chachar Tarique Shahzad , Tawfik Wael , Alqahtani Abdulrahman M. , Refaat Wael , Al-Barut Muhammad , Aithal Jairam , Altnji Issam , Ozdemir Levent , Alzahrani Badr , Alhaydhal Ahmed Naif , Arafat Amr A.
Published: February 2025

Using the SYNTAX score (SS) for decision-making between percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for left main coronary artery (LMCA) revascularization is under scrutiny. This study investigated the clinical outcomes of LMCA revascularization stratified by SS. This multicenter study included 2138 patients recruited between 2015 and 2020 who underwent LMCA disease revascularization using PCI or CABG and were categorized based on their SS into three groups: low (≤22), intermediate (23–32), and high (≥33). Patients with a high SS compared with those with an intermediate SS experienced increased hospital mortality (Odds ratio: 1.99; P = .026) and Major Adverse Cardiac and Cerebrovascular Event (MACCE; OR: 2.17; P = .006). With an average follow-up of 24.7 months, no substantial differences emerged in MACCE (Hazard ratio: 1.23; P = .52) or mortality (HR: 3.26; P = .073] between patients with high and intermediate SSs. A significant interaction between the SS category (low vs intermediate) and LMCA revascularization modality was observed for hospital MACCEs, favoring PCI over CABG (OR: 0.32; P = .033). However, no noteworthy interactions between SS categories and revascularization modalities were noted concerning hospital or follow-up mortality or follow-up MACCEs. These findings raise doubts about the utility of SS alone in selecting left-main revascularization modalities for LMCA disease.
Think Twice—An Intervention Strategy to Reduce Personal Clothing Consumption
Authors: Joanes Tina , Geiger Sonja M. , Gwozdz Wencke
Published: February 2025

This study reports the effectiveness of a theory-driven Internet based intervention aiming at reducing participants’ ( N = 415) clothing purchases. An information-only intervention and a combination of information, goal setting, goal feedback, commitment, and self-regulatory strategies was applied in four different experimental conditions, including a passive control group. At a 1-month post-test, only participants in the combined intervention groups significantly reduced their clothing purchases compared to the control and information only group, on average by 58.59% for a condition with individual goal setting and by 46.82% for a condition with collective goal setting as compared to a 1-month pre-intervention period. At a 3-month follow up, consumers across all groups reduced their clothing purchases. We explore changes in mechanisms of action and their role for changes in clothing purchases. Specific goal setting, but not a general goal to reduce clothing consumption, and goal conflict were linked to changes in purchase behavior.
Idiopathic and Metabolic Triggers Leading to Recurrent Acute Pancreatitis in a 30-Year-Old Woman
Authors: Ahmed Fahamina , Chester Taylor , Sarwar Shaina
Published: February 2025

Background: Recurrent acute pancreatitis can be influenced by a variety of factors, including metabolic and lifestyle triggers. This case report presents a 30-year-old Asian woman whose episodes of pancreatitis were complicated by hypertriglyceridemia, Type 2 diabetes mellitus (T2DM), and occasional alcohol use. Medication-related risks, such as semaglutide, were also identified as possible contributors. Case Presentation: The patient experienced three distinct episodes of acute pancreatitis. Initially admitted in June 2020, she presented with no prior medical history and denied alcohol use. During subsequent admissions in April 2023 and January 2024, the patient reported alcohol consumption. The second admission showed significantly elevated triglyceride (TG) levels (>5680 mg/dL), and the third occurred after New Year’s Eve alcohol consumption, with TG >3000 mg/dL. Treatment across all episodes involved NPO status, IV fluids, and ICU admission with insulin therapy to lower TG levels. After the recurrence of pancreatitis, her T2DM treatment was changed from semaglutide to dapagliflozin. Conclusion: This case underscores the importance of comprehensive patient education on lifestyle factors, medication risks, and adherence to treatment plans to reduce the recurrence of acute pancreatitis. Tailoring interventions, such as switching diabetes medications (from semaglutide to dapagliflozin) and emphasizing TG management through gemfibrozil, atorvastatin, and icosapent ethyl, proved essential in stabilizing her condition. The patient’s case serves as a reminder of the multiple potential causes of pancreatitis and the need for ongoing monitoring to prevent further complications.
Workers’ experiences in non-profit and for-profit managed asylum systems: A comparative analysis of Italy and Ireland
Authors: Peroni Claudia , Devitt Camilla , Faas Daniel
Published: February 2025

Does the management of asylum systems by non-profit as opposed to for-profit organizations affect workers’ experiences and satisfaction? This study explores this question through interviews with workers and other stakeholders involved in the daily implementation of asylum policy in Italy and Ireland: Italy has a public system managed by civil society actors, whereas Ireland subcontracts management to for-profit actors. We find that job satisfaction is generally high; however, a non-profit system improves workers’ experiences by providing value-based meaningfulness and interconnectedness with other public services, whereas a for-profit system provides less support in terms of available networks, regulation, transparency, and accountability. We argue that each system is the product of its state’s administrative tradition, which also shapes workers’ conceptualization of job satisfaction; however, a for-profit implementation model is ill-suited to asylum policy, especially when located within a broader context of marketized state services.
Innovative technique with enriched movement directions to plan the trajectory for an autonomous Mobile robot
Authors: Dhouib Souhail
Published: February 2025

This paper presents a deep analysis of a novel method entitled Dhouib-Matrix-SPP-24 (DM-SPP-24) and its application to rapidly generate the shortest trajectory for an autonomous mobile robot. For this problem, the environment is represented by a grid map where several obstacles are exposed with static positions and the main objective is to plan the shortest trajectory for an autonomous mobile robot from the current to the target positions with obstacles free-collisions. This study introduces an in-depth exploration of the twenty-four movement directions of the DM-SPP-24 method, an application on six grid maps and a comparison to several recent metaheuristics taken from the literature (such as the Improved Ant Colony Algorithm, the enhanced Ant Colony Optimization with Gaussian Sampling, the Particle Swarm Optimization, the Genetic Algorithm and other methods). Indeed, a new method namely DM-SPP-24 is introduced and this study notes an improvement in the quality and the rapidity of the generated solution by DM-SPP-24 versus the solution produced by the recent published metaheuristics in the literature. This work serves as a valuable resource for robotics and path planning viewing that it introduces a very fast and accurate method (DM-SPP-24) to plan the trajectory of an autonomous mobile robot.
Simulation of the fiber arrangement in a sliver based on the distribution of the sliver linear density
Authors: Liu Yanhui , Chen Jing , Wang Liping , Sun Chao , Xing Mingjie , Sun Na
Published: February 2025

The fiber arrangement in a sliver plays a significant role in determining the sliver evenness. In this research, an innovative method was proposed to simulate the fiber arrangement, based on the variation in linear density, relative to the mean values along the sliver axis, acquired from the measured distribution of the sliver linear density. The simulated results for three polymer carding slivers and three cotton carding slivers show that the fiber arrangement in the sliver can be concretely and graphically expressed by the variation of the linear density of each sliver subsection, relative to the mean sliver linear density. Moreover, the simulated sliver irregularities and frequency distributions of the carding sliver linear density in the sliver, based on the actual variation curve of the sliver linear density and the actual frequency of the sliver linear density, all conformed better to the actual slivers, compared with the simulated slivers with the method based on a random fiber arrangement. However, a comparison of the simulation results for these two methods demonstrates that the method based on the actual variation curve of the sliver linear density can only simulate the fiber arrangement of the test section. Conversely, the method based on the actual frequency distribution of the sliver linear density can simulate the fiber arrangement in the whole carding sliver, so that it is more applicable for use in further post-spinning processes with the accurate simulation results.
Eclipsing the Son: An assessment of online witness and evangelism during the 2024 solar eclipse
Authors: Teasdale Mark R.
Published: February 2025

The solar eclipse that was visible across North America on 8 April 2024 was the impetus for numerous social media posts relating to Christian witness and evangelism. Collecting and analyzing posts revealed that they could be divided into four categories:

1. Using the eclipse as the basis for in-person evangelistic engagement.

2. Proclaiming God as Creator.

3. Teaching object lessons about God’s relationship to humanity.

4. Declaring the eclipse was a message from God to humanity that demanded action.

The posts in each category were then assessed using current Protestant and ecumenical evangelism theory. This yielded three results. First, it showed that most Christians did not adhere to a specific theoretical approach to evangelism. Second, it provided insight into how effective the posts might be in reaching their target audiences. Third, in some cases it suggested how the nature and limitations of online media can affect the ways Christians discuss or engage in evangelism.
Goal Understanding and Anonymous Cyberbullying in Social Media: How Victims Interpret, Cope with, and Respond to Hurtful Messages Online
Authors: Palomares Nicholas A. , Baumler Rebecca , Kim Moo Sun , Almaneih Arjana , Dennis Maya , Ramkissoon Preetina , Rivas Gianna , Sanchez Alyssa , Sankhavaram Anish , Shore Rachel , Van Cleve Caroline , Wheless Major
Published: February 2025

We experimentally manipulated social media affordances theoretically linked to cyberbullies’ anonymity using hypothetical scenarios taking advantage of the diverse ways people get bullied by someone they can identify versus an anonymous cyberbully. Nine different social media platforms–from TikTok, Twitter, and Tumblr to Instagram, iMessage, and Email–manipulated a cyberbully’s anonymity to uncover pathways known to precipitate poor mental health in a 2 × 9 design. Inferring upward-mobility and highlight-difference goals did not predict affective outcomes; whereas inferring insecurity goals predicted increased hurt and negative emotion regardless of anonymity but inferring personal-attack goals was more hurtful, emotionally negative, and severe when victims knew the bully. Second, inferring the goals predicted decreased coping via increased use of motivation (but not identity) uncertainty reduction strategies, especially if the bully was anonymous. Third, inferences of the insecurity and personal attack goals predicted decreased attraction to the cyberbully via increased coping if the bully was anonymous.
Revisiting Military as a Total Institution: The Case of Conscript Service in Estonia
Authors: Lillemäe Eleri , Kasearu Kairi , Ben-Ari Eyal
Published: February 2025

This article revisits the concept of the military as a total institution through the lens of conscript service in Estonia. Employing a longitudinal qualitative methodology, it captures the dynamic experiences of conscripts. The findings reveal that tensions arise as conscripts face the totality of their service, leading to short-term situational negotiations and long-term goal adaptations. The study underscores the significant role of transitions between military and civilian life, with these movements serving as key moments of reflection and reshaping conscripts’ perspectives on their service. The findings show that the military has begun paying more attention to individual life courses and aligning its practices with civilian workplaces. While these adaptations align with societal expectations and aim to maintain the institutional legitimacy, they also contribute to the normalization of the military organization, potentially eroding the appeal of conscript service.
CT-based radiomics predictive model for spread through air space of IA stage lung adenocarcinoma
Authors: Chen Song , Wang Xiang , Lin Xu , Li Qingchu , Xu Shaochun , Sun Hongbiao , Xiao Yi , Fan Li , Liu Shiyuan
Published: February 2025

Background

Spread through air spaces (STAS) in lung adenocarcinoma means different treatment and worse prognosis.

Purpose

To construct a radiomics model based on CT scans to predict the presence of STAS in stage IA lung adenocarcinoma, compared with the traditional clinical model.

Material and Methods

The study included 317 patients (median age = 57.21 years; age range = 45.84–68.61 years) with pathologically confirmed stage IA lung adenocarcinoma. In total, 122 (38.5%) patients were diagnosed with STAS by pathology after the operation. Two experienced radiologists independently segmented the lesions using MITK software and extracted 1791 radiomics features using Python. Single-factor t-test or Mann–Whitney U-test and LASSO were used to screen for radiomics signatures related to STAS. This study constructed a radiomics model, a clinical model, and a combined model, combining radiomics and clinical features. Model performance was evaluated using the area under the curve (AUC).

Results

By single-factor analysis, four clinical features and 13 radiomics features were significantly associated with STAS. The three models (the clinical, radiomics, and combine models) achieved predictive efficacy, with an AUC of 0.849, 0.867, and 0.939, respectively, in the training set and 0.808, 0.848, and 0.876, respectively, in the testing set.

Conclusion

The combined model based on the radiomics and clinical features of preoperative chest CT could be used to preoperatively diagnose the presence of STAS in stage IA lung adenocarcinoma and has an excellent diagnostic performance.
LIS sector’s contributions to climate action: Indicators for measuring success
Authors: Chowdhury Gobinda , Jack Ellie , Chowdhury Sudatta , MacQuarrie Kirsten , McNamara Sean
Published: February 2025

A survey was conducted among the public and school libraries in Scotland to gather data on the different kinds of activities being undertaken for achieving and promoting sustainability, and especially Sustainable Development Goal 13 (SDG13) (climate change). These activities were mapped onto the targets and indicators of SDG13 and some targets and indicators of other SDGs that contribute to SDG13. Based on this, two simple templates are proposed for recording and reporting the activities of the library and information science (LIS) sector towards SDG13. Some simple measures for recording the outcomes and impact of some such activities are also proposed.
"I'm Feeling and I'm Bleeding”: The Unspoken Impact of Menstrual Cycles on Social Workers Through a Trauma-Informed Feminist Lens
Authors: Ichikawa Viveka , Yoon Elise Suk Young
Published: February 2025

Guided by a trauma-informed feminist lens, this manuscript explores the often-overlooked impact of menstrual cycles on social workers. Menstruation remains a taboo topic across diverse contexts. The ways in which individuals cope—through personal professionalism—reflect broader societal expectations to minimize or silence normalized pain. This highlights a deeper, sexism-rooted injustice in the workplace, where the physical experiences of women and other gender identities—such as menstruation, pregnancy, pregnancy-related loss or recovery, and menopause—are often dismissed. Such attitudes perpetuate the myth of the “perfectly functional” professional body, shaped by male, able-bodied norms and neoliberal expectations.
In-hospital outcomes of patients with antiphospholipid syndrome undergoing transcatheter and surgical aortic valve replacement: A population-based analysis of national inpatient sample from 2015–2021
Authors: Li Renxi , Huddleston Stephen J
Published: February 2025

Background

Valvular abnormalities are common in antiphospholipid syndrome (APS). For patients who undergo aortic valve replacement (AVR), previous single institutional studies or case reports reported higher risks of mortality and thromboembolic complications among APS patients. This study aimed to investigate in-hospital outcomes of APS patients undergoing transcatheter (TAVR) and surgical aortic valve replacement (SAVR) using the largest all-payer database in the United States.

Methods

Patients who underwent TAVR and SAVR were selected from National Inpatient Sample from Q4 2015-2021. Exclusion criteria were age under 18 years and concomitant procedures. Preoperative characteristics were matched between APS and non-APA patients using a 1:5 propensity-score matching in TAVR and SAVR, separately. In-hospital outcomes were examined.

Results

After propensity-score matching, 504 non-APS patients were matched to 100 APS patients in TAVR, while 581 non-APS patients were matched to 119 APS patients in SAVR. All outcomes between APS and non-APS patients were comparable after TAVR. In contrast, APS patients undergoing SAVR had higher risks of pulmonary embolism (PE; 5.13% vs 0.86%, p < .01) and acute kidney injury (AKI; 35.04% vs 22.55%, p = .01).

Conclusion

This study represents one of the first large-scale, population-based analyses of AVR outcomes for APS patients using a national registry. APS patients had all comparable outcomes after TAVR, while they had higher risks of PE and AKI after SAVR. This highlights the necessity for close perioperative antithrombotic management and careful monitoring of renal function in APS patients. TAVR may offer a safer alternative to SAVR for appropriately selected patients, including those with APS.
Soluble Urokinase Plasminogen Activator Receptor in Full–Term Neonates with Sepsis: Relation to Disease Severity and Clinical Outcome
Authors: Shinkar Dina Mohamed , Ismail Eman Abdel Rahman , Abdallah Heba Ibrahim , El-Shimi Mohamed Sami
Published: February 2025

Background

Urokinase plasminogen activator receptor (uPAR) is a membrane-linked receptor that has extracellular protease activity and is expressed on various cell types. We evaluated soluble uPAR (suPAR) as an early diagnostic and prognostic marker for neonatal sepsis.

Methods

Baseline serum suPAR levels were measured in 70 full-term neonates with proven sepsis on admission and repeated 48 hours after antibiotic therapy. suPAR levels were compared with 35 age- and sex-matched healthy controls.

Results

Baseline suPAR levels were significantly elevated in septic neonates compared with controls ( P < .001). Patients with culture-positive sepsis ( n = 48) and culture-negative sepsis ( n = 22) had higher suPAR compared with controls but no significant difference was found between both septic groups. Baseline suPAR was significantly higher among neonates with septic shock and those who had a worsening disease course or died. suPAR was decreased 48 hours after antibiotic therapy in neonates whose blood cultures turned negative. suPAR cutoff value of 6 ng/mL predicted worsening clinical course with 82.4% sensitivity and 88.9% specificity, while the cutoff value of 7.1 ng/mL predicted mortality with 94.4% sensitivity and 82.4% specificity.

Conclusion

suPAR may be considered an early marker for neonatal sepsis and is a powerful predictor of sepsis severity and mortality among neonates with sepsis.
Campylobacter jejuni hepatitis in a horse: case report and literature review
Authors: Macías-Rioseco Melissa , Ochoa Jennine , Choi Eunju (April) , Blanchard Patricia , Moeller Robert B. , Uzal Francisco A.
Published: February 2025

Campylobacter spp. can cause gastroenteritis, hepatitis, bacteremia, and abortions in domestic animals and humans. Some Campylobacter spp. are zoonotic. To our knowledge, hepatitis caused by Campylobacter jejuni has not been reported in horses. Here we present a case of acute necrosuppurative hepatitis caused by C. jejuni infection in a 3-y-old gelding, and we review the literature on C. jejuni infections in various animal species. The horse had a one-week history of weight loss and weakness before becoming recumbent and dying. Grossly, the liver had rounded edges and was mottled. There were ecchymoses on the gastric serosa, and a large amount of mucoid, pale, green-to-yellow content adhered to the mucosa of the small and large intestines. Microscopically, random areas in the liver were necrotic and infiltrated by large numbers of neutrophils, and fewer lymphocytes and plasma cells. Other changes in the liver included neutrophilic cholangitis with bile duct hyperplasia in portal areas, canalicular cholestasis, and mild portal fibrosis. The lamina propria, and occasionally the submucosa, of the small intestine and colon was infiltrated by large numbers of lymphocytes and plasma cells, and there was multifocal crypt necrosis. C. jejuni was recovered in pure culture from the liver.
Effects of Medical–Financial Partnerships on Financial and Medical Outcomes: A Systematic Review
Authors: Birkenmaier Julie , Maynard Brandy R. , Blumhagen Harly M. , Shanks Hannah
Published: February 2025

Purpose: This systematic review synthesizes empirical evidence on the health and financial outcomes of Medical–Financial Partnerships to inform policy and practice. Method: We followed the Methodological Expectations of Campbell Collaboration Intervention Reviews to conduct this review. We searched 10 electronic databases through September 2023 to locate randomized controlled trials or quasi-experimental studies. Risk of bias of the included studies was assessed with the Cochrane risk of bias tools. This review was registered with the Campbell Collaboration. Results: Two randomized controlled trials and two quasi-experimental designs including a total of 410 participants were included in the review. Evidence on health and financial impacts was limited due to the small number of studies and lack of effect size data. Results indicated small, nonsignificant effects on financial outcomes. Risk of bias varied. Discussion: Despite growing popularity, there is insufficient evidence to determine if Medical–Financial Partnerships are meeting their goals.
Predictors of participation over the 10 years after TBI in black individuals
Authors: Ohayagha Chimdindu , Xia Bridget , Jones Shawn CT , Klyce Daniel W , Arango-Lasprilla Juan Carlos , Perrin Paul B
Published: February 2025

Objective

This study examined: (a) longitudinal trajectories of participation over the 10 years after traumatic brain injury (TBI) in a group of Black individuals, and (b) demographic and injury-related predictors of those trajectories.

Method

This study included 1,989 Black individuals in the national TBI Model Systems (TBIMS) Database, who had at least one of each Participation Assessment with Recombined Tools-Objective (PART-O) subscale scores at one or more follow-up time points (1, 2, 5, and 10 years after TBI).

Results

Lower PART-O Productivity trajectories were observed among participants who were male (b = −.26, p = .001), were older at the time of injury (b = −.02, p < .001), had a lower education level (b = .06, p < .001), had public insurance coverage (b = .17, p = .009), and had longer posttraumatic amnesia (PTA) duration (b = −.28, p < .001). Lower PART-O Social trajectories emerged among participants who were older at the time of injury (b = −.02, p < .001), did not have a partner at the time of injury (b = .66, p < .001), had public insurance coverage (b = .19, p = .009), and had longer PTA duration (b = −.19, p = .001). Lower PART-O Out and About trajectories emerged among participants who were older at the time of injury (b = −.01, p = .018) and had a lower education level (b = .05, p < .001).

Conclusion

The findings highlight the importance of understanding the strengths, risk factors, and unmet needs of this group, many of whom experience decreased community and social engagement after TBI.
Optimised two-stage technique for sheath–dilator insertion in peripherally inserted central catheter placement
Authors: Young Ting-Chia , Cheng Kuang-Hua , Yu Kuan-Pen
Published: February 2025

Background:

Peripherally inserted central catheters (PICCs) provide a valuable alternative to traditional central venous access, offering smaller-diameter lines and supporting prolonged infusion therapy. Although recent advancements have addressed many of the initial challenges of PICC insertion, some catheter-related complications remain significant. In cases of mechanical complications, shearing of the peel-away sheath typically occurs while inserting the sheath–dilator, necessitating further dermatotomy and thereby increasing patient morbidity.

Materials and methods:

The alternative technique involved disassembling the sheath–dilator apparatus into its individual components: the peel-away sheath and introducer dilator. After successfully advancing the guidewire through the needle, the dilator alone was inserted over the guidewire and then removed. Subsequently, the dilator and sheath were reassembled and inserted simultaneously through the skin. The study included four patients (mean age, 55.75 (range: 26–78) years), all of whom underwent PICC placement using the proposed method.

Results:

Advanced dilator insertion effectively prevented sheath shearing and facilitated successful PICC placement on the first attempt in all patients. No haematomas or catheter-related complications were observed.

Conclusions:

Using the alternative technique, a high success rate of first-attempt PICC insertions was achieved. This approach may reduce the need for additional dermatotomy, thus minimising patient morbidity and improving procedural outcomes.
Rapid cognitive assessment: Accuracy and discriminant validity of Mini-Cog and process-based Clock Drawing Test
Authors: Yang Qian , Yang Hao , Long Wei , Zuo Sheng , Zhu Defa , Guo Qihao
Published: February 2025

Background

The Mini-Cog is a brief cognitive examination comprising a three-item memory recall and a simplified Clock Drawing Test (CDT). There is limited research on the effects of detailed scoring criteria for the Mini-Cog on cognitive screening.

Objective

To assess the diagnostic effectiveness of three Mini-Cog versions and a new process-based CDT test in identifying mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to cognitively normal controls (NC).

Methods

We prospectively enrolled 950 subjects who underwent standardized neuropsychological assessments and the Mini-Cog test. The CDT was scored using an adapted 10-point scale. The accuracy of three Mini-Cog versions (Mini-Cog1: 3-word delayed recall + 2-point CDT; Mini-Cog2: 3-word immediate recall + 3-word delayed recall + 3-point CDT; Mini-Cog3: 3-word immediate recall + 3-word delayed recall + 10-point CDT) was assessed through the receiver operating characteristic analysis. Sensitivity and specificity were determined for each diagnostic threshold.

Results

The optimal cut-off point for Mini-Cog3 is 12/16 for MCI and 10/16 for AD. Mini-Cog3 demonstrated the highest diagnostic efficacy, with AUCs of 0.82 (95% CI: 0.78–0.85) for MCI and 0.95 (95% CI: 0.94–0.97) for AD, with sensitivity of 85% for both MCI and AD. The CDT's AUCs were 0.77 (95% CI: 0.73–0.81) for MCI, and 0.87 (95% CI: 0.84–0.90) for AD, with sensitivity of 89% for MCI, and 82% for AD.

Conclusions

A more elaborate scoring system, such as Mini-Cog3, may serve as an effective screening method for the rapid and accurate detection of cognitive dysfunction in patients with MCI and AD.
The limits of platforms: Why disintermediation has failed in the art market
Authors: Ricucci Rachel , Blank Grant
Published: February 2025

Platforms have disintermediated the markets for books, film, television, and music, but the online art market has reproduced offline structures, leaving intermediaries intact. This study explores the limits of platforms by describing why disintermediation failed in the art market. Along with museums and other intermediaries, the most important function of galleries is to co-create artistic value. They not only sell art but also form a central part of the status system of art. We examine #artistsupportpledge (ASP) on Instagram. ASP uncovered a market for art that had no place in the existing system. ASP facilitated direct sales to consumers while allowing artists to maintain links to galleries for reputation, career development, exhibitions, and sales of large, expensive work. The art market experienced unique partial disintermediation under narrow conditions with continued allegiance to existing intermediaries and status structures. We conclude by discussing four implications for the theory of platforms.
Organisational ambidexterity and sustainable value co-creation in a social enterprise: The case of Social Bite
Authors: Brown David M , Pattinson Steven
Published: February 2025

This case focuses on the concept of organisational ambidexterity, its relevance to social entrepreneurs, and its contribution to sustainable value co-creation. It examines how social enterprises must adapt to newly emerging challenges while simultaneously delivering upon their core mission. A Chief Executive Officer recalls how he reacted swiftly to capitalise upon unanticipated opportunities without being deflected from vital routine operations. He was successful in significantly raising the profile – and consequently the economic and social sustainability – of his social enterprise by harnessing a sudden Public Relations opportunity. The case considers how organisational ambidexterity and ‘agility’ can contribute to social entrepreneurship. The concept is explored in the context of Social Bite, an Edinburgh-based social enterprise which provides housing, employment, food, and support to individuals facing homelessness. Finally, the case also considers the relationship between organisational ambidexterity and sustainable value co-creation.
Construction of financial fraud identification model based on stacking and accounting indicators
Authors: Li Huizhi , Yu Xianghua
Published: February 2025

In recent years, with financial fraud events coming one after another, the legitimate rights and interests of consumers have been seriously damaged. To solve the problem that financial fraud behaviors are more difficult to identify and more hidden, the study proposes a financial fraud identification model based on stacked integrated learning model and accounting metrics. The model adopts a multi-level feature extraction method and combines multiple base learners and logistic regression to identify financial fraud based on accounting metrics. In this study, the accuracy of the Stacking model is 85.23%, which is 5.32% higher than that of the other 5 Stacking models. Compared with other feature models, the accuracy and F1-score of the recognition model based on accounting index are increased by 18.68% and 19.11% on average. The study indicates that the financial fraud identification model based on Stacking as well as accounting metrics has good performance along with low under reporting rate for fraudulent firms. The study explores financial fraud from multiple dimensions based on annual reports, which can effectively reduce the human economic losses caused by financial fraud and assist the development of anti-fraud behavior.
Encoder-based attention mechanism deep learning network for clip damage detection in metal roofing systems
Authors: Zou Li , Hu Jun , Lam Heungfai , Chung Kwok Fai , Zhuang Kejia
Published: February 2025

In the realm of civil engineering, ensuring the structural integrity of roofing systems is paramount for building safety. Traditional methods for damage detection often fall short in terms of accuracy and efficiency, necessitating advancements in this critical area. This study aims to address these challenges by introducing an encoder-based attention mechanism (EAM) deep learning network designed specifically for the detection of damage within roofing structures. By strategically deploying sensors in a matrix layout and employing Fourier transforms to convert time-domain data into spectral images, the proposed deep learning network can leverage the advantages of convolutional structure and enhance the identification and extraction of damage-related features in roof systems. Furthermore, the integration of the newly designed EAM enables the model to focus on relevant features more effectively, significantly improving damage detection accuracy. Experimental validations conducted on real-world structures demonstrate the model’s capability to accurately and efficiently identify structural damage, marking a significant advancement over conventional methods.