bluuebunny/crossref_metadata_2025 huggingface dataset:
temps comme degrés d'engagement épistémique
Authors: Jaszczolt Katarzyna M.
Published: July 2022

This article addresses the question as to whether time is a primitive concept or rather is composed of conceptually more basic building blocks. After a brief analysis of tense-time mismatches with examples from English, Polish, Thai and Swahili, I present a hypothesis that time is conceptualized in terms of degrees of epistemic modality. Expressions with future, present and past reference are ordered on scales of epistemic commitment. I demonstrate that the theory of Default Semantics has no difficulty with representing tense-time mismatches in that it reflects the fact that information about temporality is conveyed via a variety of processes, some of them pertaining not to the processing of the lexicon or grammar but even to pragmatic inference. The theory also gives support to the thesis of time as modal detachment.
L’orthographe dans l’élaboration des niveaux de référence pour le français
Authors: Luzzati Daniel
Published: July 2022

In the framework of the CEFR, language versions for French devotes a chapter from A1 to "graphic material". These chapters are designed according to phonology, vocabulary –especially homophones –, grammatical words and verbal features. A1/A2 & B1/B2 are now completed. Thus, it becomes interesting to ask a few questions:
- Is the title "matière graphique" relevant?
- Prejudgements (plan, verbal morphology by basis...) are they timely?
- Is the hierarchy of skill levels working with spelling?
- Is the skill levels succession expected by the CEFR working with spelling?
- What could be C reference levels?
Positions, positionnements et postures de l'énonciateur
Authors: Rabatel Alain
Published: July 2022

This article draws connections between the notions of enunciator position, positioning and posture, which structure the dialogic, cognitive and interactional co-production of utterances. The notion of enunciative position corresponds to the fact that the (first or second) enunciator refers to objects of discourse while positioning himself/herself with regard to them, by indicating from what point of view he/she considers them. In view of the dialogic nature of the discourse, two modal subjects and levels of responsibility can be discerned: the first enunciator has the role of the agent in charge of the discourse and the second enunciators fulfill internal functions of validation, assuming thus a sort of responsibility which does not necessarily commit the first enunciator. The article then analyses the dialogic strategies of positioning by enunciative reduplication and separation which account for auto-dialogic and hetero-dialogic situations. Finally it deals with the enunciative postures of co-enunciation, over-enunciation and under-enunciation, which refine the notions of enunciative reduplication or separation, by specifying the degrees of agreement, according to a dialectic between discordant concordance and concordant discordance.
paysage linguistique : reflet d'une réalité bilingue à Moncton, Nouveau-Brunswick, Canada
Authors: Boschung Susanne
Published: July 2022

The linguistic landscape of Moncton, New Brunswick, Canada, seems particularly interesting because Moncton is situated at the edge of the Acadian French-speaking territory. It therefore represents a mixed region where French- and English-speaking inhabitants share space. Near Moncton lies Dieppe, a community with 74% of French-speaking inhabitants, but also Riverview, where 80% of the population is English-speaking. Both cultures collide in downtown Moncton. The results of this study show that even though English is clearly the dominant language, apparently existing as an independent culture, as seen in unilingual signs and symbols, French occupies its own, yet shared, space in this linguistic landscape. There is a surprising interaction between English and French, visible in signs that mix both languages by using syntactic differences, which seems to indicate that the inhabitants of Moncton are used to both languages and are relatively at ease with it.
Sharing perception when using hands-on exhibits in science centres: the case of vocal depiction
Authors: Brandenberger Christina , Hottiger Christoph
Published: July 2022

There are various situations in our daily lives in which we share sensory perceptions in interaction, but research on how exactly we do this is relatively scarce and has often focused primarily on the visual and auditory channels. In this paper, we suggest an approach based on the methods of multimodal conversation analysis which also considers other perceptual fields, especially touch. By means of an example from an interaction between two visitors of a science centre and the way they handle an exhibit, we illustrate how one can approach the analysis of the techniques participants use to make their sensory perceptions available to their interactive partners. We will focus on one such technique, namely the vocal depiction of tactile perceptions.
Intentional communication in primates
Authors: Zuberbühler Klaus
Published: July 2022

Human communication, including language, is the product of underlying intentions that are purposely expressed, epistemically monitored and flexibly interpreted. A main question in science has been about the evolutionary origins of this cognitive capacity. One way to address the problem is by studying the natural communication of animals, particularly nonhuman primates. As everything in biology, evolutionary transitions are gradual events, suggesting that intention may also have evolved in different stages as a function of increasing brainpower and cognitive complexity. In this chapter, I review empirical work on primate communication, which suggests that goal-directed intentional communication is well within the scope of animals, while simple mind-directed intentionality may be restricted to great apes and humans and shared intentionality may be an exclusively human capacity.
A design approach to team coordination
Authors: Avdiji Hazbi , Missonier Stéphanie
Published: July 2022

Team coordination over long time scales has been analyzed through two dominant perspectives: the contingency approach and the discursive approach. While they produced extensive theoretical contributions, these two perspectives are not well-suited to understand team coordination in changing and uncertain situations such as innovation projects. In this paper, we propose a design approach to coordination, which we define as the joint inquiry and construction by teams of their common ground. We instantiated our conceptual model into a tool called the Team Alignment Map, which allows team members to design their interdependencies. We evaluated the effectiveness of the tool within 22 innovation projects in two different settings. Our findings suggest that the tool facilitated the creation of shared understanding between team members, and allowed them to coordinate flexibly and welcome the shifting requirements of their projects. These findings suggest that conceptualizing coordination as a design process is well-suited to innovation projects.
Expanding the Reactivity of Flavin Dependent Halogenases Toward Olefins via Enantioselective Intramolecular Haloetherification and Chemoenzymatic Oxidative Rearrangements
Authors: Jiang Yuhua , Mondal Dibyendu , Lewis Jared
Published: July 2022

Of the different classes of halogenases characterized to date, flavin dependent halogenases (FDHs) are most commonly associated with site-selective halogenation of electron rich arenes and enol(ate) moieties in the biosynthesis of halogenated natural products. This capability has made them attractive biocatalysts, and extensive efforts have been devoted to both discovering and engineering these enzymes for different applications. We have established that engineered FDHs can catalyze different enantioselective halogenation processes, including halolactonization of simple alkenes with a tethered carboxylate nucleophile. In this study, we expand the scope of this reaction to include alcohol nucleophiles and a greater diversity of alkene substitution patterns to access a variety of chiral tetrahydrofurans. We also demonstrate that FDHs can be interfaced with ketoreductases to enable halocyclization using ketone substrates in one-pot cascade reactions and that the halocyclization products can undergo subsequent rearrangements to form novel hydroxylated and halogenated products. Together, these advances expand the utility of FDHs for enantio- and diastereoselective olefin functionalization.
The burden of city’s pain treatment – a longitudinal one year study of two cities via wastewater-based epidemiology
Authors: Kannan Andrew , Sims Natalie , Hold Angus , Jagadeesan Kishore , Standerwick Richard , Barden Ruth , Kasprzyk-Hordern Barbara
Published: July 2022

This paper explores Wastewater-Based Epidemiology (WBE) as a tool enabling understanding of city’s pain treatment in an intercity longitudinal study. An intensive 13-month monitoring programme was undertaken in two adjacent urban areas in South-West England: a small commuter town Keynsham and the city of Bath. The study has shown a great potential of using triangulated WBE and National health Service (NHS) prescription data in understanding pain treatment in two contrasting communities with strong apparent seasonal patterns of short pain medications vs chronic pain treatment as well as the type of treatment used (e.g. oral vs topical). Community-wide usage of NSAIDs and paracetamol in the intercity study is population size and season driven with the highest usage recorded in winter months. This contrasts with other pain pharmaceuticals, especially those used for chronic pain, where no/limited seasonal usage was recorded. Unmetabolized NSAIDs are, to a large extent, directly disposed of into the sewerage system bypassing metabolism due to their preferred topical application. This is particularly apparent in winter months with naproxen showing the highest seasonal variability. Pharma/met analysis allows for tracking topical (non-metabolic) application/down-the-drain disposal of pharmaceuticals with frequent instances of direct disposal of NSAIDs into the sewerage system observed. Normalisation of pharma markers to population size shows comparable estimates of pharma usage in the two cities confirming population as the main driver of pharma loads in wastewater. Variable application patterns of pain pharmaceuticals make back-calculation of intake more convoluted. Intake calculated using percentage of urinary/faecal excretion of metabolites or parent compounds as consumption markers leads to likely underestimation of NSAIDs usage due their both oral and topical application. Prescription data indicates cumulative internal and topical usage.
Probing the Stability of SrIrO3 During Active Water Electrolysis via Operando Atomic Force Microscopy
Authors: Akbashev Andrew R. , Roddatis Vladimir , Baeumer Christoph , Liu Tianchi , Mefford J. Tyler , Chueh William C.
Published: July 2022

Mechanistic studies of oxide electrocatalysts for heterogeneous water oxidation have been primarily focused on understanding the origins of activity, with fewer studies studying fundamental properties influencing stability. The main challenge is directly observing and quantifying local structural instability under operating conditions. In this work, we provide a dynamic view of the perovskite stability as a function of time and operational voltage using operando electrochemical atomic force microscopy (EC-AFM). Specifically, we study the degradation pathways of SrIrO3, a highly active electrocatalyst, during the oxygen evolution reaction (OER) by tracking the potential-dependent Sr leaching and perovskite dissolution at the nanometer scale. This material serves as a model system for degradation studies of perovskite AMO3 oxides, exhibiting both A-cation leaching and transition metal (M) dissolution. We show that Sr leaching precedes perovskite dissolution by up to 0.8 V, leading to a wide voltage window of stability where water oxidation occurs on a Sr-depleted surface without significant corrosion. Moreover, we reveal that the stability of the perovskite surface is strongly influenced by the electrolytic environment and that corrosion rates differ dramatically as a function of dissolved Sr concentration. Ultimately, our study demonstrates the overall stability of perovskite oxides during electrocatalysis can be substantially improved by suppressing A-site leaching.
Electric-Field-Induced Coupling of Aryl Iodides with a Nickel(0) Complex
Authors: Orchanian Nicholas , Guizzo Sophia , Steigerwald Michael , Nuckolls Colin , Venkataraman Latha
Published: July 2022

The influence of electric fields has been postulated as a major factor for rapid catalysis in enzymatic systems. Here, we show that external electric fields can modulate the reactivity of an otherwise kinetically inert transition metal complex to affect a coupling reaction. An air-stable nickel(0) complex is demonstrated to exhibit no reactivity towards the oxidative addition of aryl iodides at room temperature. However, when an external electric field was applied to this reaction solution with a scanning tunneling microscope, the biaryl coupling product was detected in-situ through single-molecule conductance measurements and ex-situ through high-resolution mass spectrometry. These results highlight the importance of electric field effects in reaction chemistry, and demonstrate the application of STM studies towards electric field induced organometallic transformations.
Machine Learning Predicts Conversion and Molecular Weight Distributions in Computer Controlled Polymerization
Authors: Tan Jin Da , Ramalingam Balamurugan , Wong Swee Liang , Cheng Jayce , Lim Yee-Fun , Chellappan Vijila , Khan Saif A. , Kumar Jatin , Hippalgaonkar Kedar
Published: July 2022

The skew and shape of the Molecular Weight Distribution (MWD) of polymers have a significant impact on polymer physical properties. Standard summary metrics statistically derived from the MWD only provide an incomplete picture of the polymer MWD. Machine learning (ML) methods coupled with high-throughput experimentation (HTE) could potentially allow for the prediction of the entire polymer MWD without information loss. In our work, we present a computer controlled HTE platform that is able to run up to 8 unique variable conditions for the free radical polymerizations of styrene. The segmented-flow HTE system was equipped with an inline Raman spectrometer and offline size exclusion chromatography (SEC) to obtain time dependent conversion and MWD respectively. In a supervised learning exercise, the gradient-boosted decision trees ML algorithm was used to predict monomer conversion from reagent concentrations and reaction time with high accuracy, using data obtained from the Raman spectra. A second ML algorithm uses the random forest regressor to predict entire MWDs of the synthesized polymer. Each algorithm can navigate the complexity of multiple parallel reactions occurring in a polymerization. The algorithm accurately predicts monomer conversion in the first case despite variations in the polymerization kinetic parameters over time. In the second case, we predict the polymer MWD where fine details such as the shape and skew of the MWD are captured without information loss. SHAP values were calculated to examine the dependence of the ML model output on the experimental conditions. A transfer learning approach was also used to enhance the predictive power of a Deep Neural Network (DNN) model in predicting batch polymerization MWDs. Overall, we demonstrate that the combination of HTE and ML provide a high level of predictive accuracy in determining polymerization outcomes, providing polymer chemists with the ability to target the synthesis of polymers with desired properties via the predicted conversion and MWD.
The third-line therapy for patients with metastatic colorectal cancer: regorafenib or repeated administration of drugs? A review
Authors: Rykov Ivan V. , Chubenko Viacheslav A.
Published: July 2022

To this date, the treatment of metastatic colorectal cancer involves continuous drug therapy, the so-called "continuum of care" approach in order to control of tumor growth and try to increase life expectancy for patients. The characteristic is the limited availability and insufficient number of third- and subsequent-line therapy. The main options for the treatment of resistant forms of metastatic colorectal cancer in real practice are the alternation of chemotherapy regimens, targeted drugs and the application of regorafenib. The choice of the treatment tactics is influenced by the patient's condition, the previous treatment and the efficacy, the molecular status of the tumor. The correct sequence of use of such approaches is currently not clearly defined and is the subject of many discussions and retrospective studies. The article discusses the main trends in the application of targeted antiangiogenic therapy for this category of patients.
Combination therapy regimens in the treatment of metastatic renal cell carcinoma: A review
Authors: Zukov Ruslan A. , Chernyaev Denis V. , Zulkaidarova Alexandra R.
Published: July 2022

Renal cell carcinoma (RCC) is one of the most common tumor types in urologic oncology practice. Despite the improvement of diagnostics methods, about 1/3 of patients with renal cell carcinoma have distant metastases at presentation resulting in an extremely high death rate. For many years, treatment of advanced forms of RCC was utterly ineffective. Standard chemotherapy regimens with fluoropyrimidines and antitumor antibiotics, cytokine therapy with interleukin-2, and interferon- only slightly prolonged the life of patients while causing severe toxic side effects and anemia. Attempts to treat the tumor with radiation therapy have also failed and have been used only for symptomatic treatment of distant metastases. The introduction of tyrosine kinase inhibitors (TKIs) in the treatment of metastatic RCC (mRCC) has enabled much more significant results. Thus, a landmark event was the approval of TKIs sunitinib and then sorafenib, pazopanib, axitinib, lenvatinib, cabozantinib, and mammalian target of rapamycin (mTOR) inhibitors: everolimus and temsirolimus. Subsequent combined therapy using bevacizumab with low-dose interferon- and lenvatinib with everolimus improved recurrence-free survival and objective response rates but contributed to increased toxicity of therapy. The next step in RCC therapy was the approval of the combination of the immuno-oncology agents ipilimumab and nivolumab for the treatment of mRCC by the U.S. Food and Drug Administration in April 2018. Later, combinations of immune checkpoint inhibitors with targeted agents were approved, which increased the life expectancy of patients and reduced the toxicity of antitumor therapy. One of the most effective regimens is the combination of a TKI axitinib or lenvatinib with the PD-1 inhibitor pembrolizumab. This article addresses the current progress in the treatment of patients with mRCC, reviewing the results of completed clinical trials on the use of combination therapy with targeted and immuno-oncology agents.
AT THE ORIGINS OF THE FIRST WORLD WAR: MUTINY IN THE EUROPEAN MIND
Authors: Булдаков Владимир Прохорович
Published: July 2022

Анализируя причины возникновения Первой мировой войны, историки готовы признать, что «Европа сошла с ума», но причин этому феномену не находят. По-прежнему господствует представление, что «разумные» политики могли бы предотвратить европейский конфликт. Автор показывает, что истоки войны были глубже. Ей предшествовал рост крайнего эмоционального напряжения во всех слоях европейского общества, обусловленный демографическим бумом, омоложением населения, информационной революцией и другими факторами, своевременно не замеченными исследователями. В этих условиях столкнулись между собой идеи империализма и интернационализма, милитаризма и пацифизма, национализма и социализма. В результате коммуникативный разум оказался подавлен своего рода коммуникативным инстинктом, что и сделало возможным возникновение европейской войны.

Analyzing the causes of the outbreak of the First World War, historians are ready to admit that«Europe has gone crazy», but they do not find the reasons for this phenomenon. The notion still prevails that «rational minded» politicians could have prevented a European conflict. The author shows that the origins of the war were deeper. It was preceded by an increase in extreme emotional tension in all strata of European society, due to the demographic boom, the rejuvenation of the population, the information revolution and other factors not noticed by researchers. Under these conditions, the ideas of imperialism and internationalism, militarism and pacifism, nationalism and socialism clashed. As a result, the communicative mind was suppressed by a kind of communicative instinct, which made possible the outbreak of European war.
RUSSIAN PRESENCE IN THE HOLY LAND IN THE TWENTIETH CENTURY. MODERN RUSSIAN HISTORIOGRAPHY
Authors: Каиль Максим Владимирович
Published: July 2022

Статья посвящена анализу актуальной российской историографии и в целом научному осмыслению российского присутствия в Святой земле в период с начала Первой мировой войны до конца советской эпохи. В центре внимания - научный (исторический) опыт осмысления ценности Святой земли и российского присутствия в регионе в политическом и религиозном контекстах. Анализируется сюжетный план, тематическая фокусировка исследований последнего десятилетия, а также познавательные подходы авторов, занимающихся ныне изучением российско-палестинских связей, структур ИППО и историей Русской духовной миссии в Иерусалиме. Характеризуется появление поколения молодых исследователей палестинской проблематики, применяемые ныне подходы и формируемые трактовки.

The article is devoted to the analysis of current Russian historiography and scientific understanding of the Russian presence in the Holy Land in the period from the beginning of the First World War to the end of the Soviet era. The focus is on the scientific (historical) experience of understanding the value of the Holy Land and the political and diplomatic presence in the region in political and religious contexts. The plot plan, the thematic focus of the research of the last decade, as well as the cognitive approaches of the authors are analyzed.
CURRENT ISSUES OF INTERNATIONAL CIVIL PROCEDURE IN THE ASPECT OF THE THEORY OF CONSTITUTIONAL USE
Authors: Крусс Ирина Александровна
Published: July 2022

Анализируется необходимость и значимость изучения иностранных юрисдикций и специфики юридических связей, обусловленных иностранными правопорядками, в механизме обеспечения реализации конституционного права на судебную защиту в Российской Федерации. В рамках анализа актуальности вопроса с позиций конституционной онтологии и методологии права заявляется о необходимости выявления и исследования особенностей учета и применения положений международных договоров, нормативных процессуальных элементов правовых систем зарубежных стран и иностранных судебных прецедентов в российской судебной практике.

The article analyzes the necessity and importance of studying foreign jurisdictions and the specifics of legal relations caused by foreign legal systems in the mechanism of ensuring the implementation of the constitutional right to judicial protection in the Russian Federation. As part of the analysis of the relevance of the issue, from the standpoint of constitutional ontology and methodology of law, it is stated that it is necessary to identify and study the features of accounting and application of the provisions of international treaties, regulatory procedural elements of legal systems of foreign countries and foreign judicial precedents in Russian judicial practice.
ON CERTAIN PROVISIONS OF DRAFT FEDERAL LAW N 40361-8 «ON GENERAL PRINCIPLES OF ORGANIZATION OF LOCAL SELF-GOVERNMENT IN THE UNIFIED SYSTEM OF PUBLIC AUTHORITY»
Authors: Очагова Валерия Станиславовна
Published: July 2022

Статья посвящена исследованию проекта Федерального закона № 40361-8 «Об общих принципах организации местного самоуправления в единой системе публичной власти». Проведен сравнительный анализ действующего Федерального закона от 6 октября 2003 г. № 131-ФЗ «Об общих принципах организации местного самоуправления в Российской Федерации» и нового законопроекта. Рассмотрен вопрос реформирования социально-культурной сферы в контексте данного законопроекта.

The article is devoted to the study of the draft Federal Law N 40361-8 «On the general principles of organizing local self-government in a single system of public power». A comparative analysis of the current Federal Law of October 6, 2003 No. 131-FZ «On the General Principles of Organizing Local Self-Government in the Russian Federation» and a new bill was carried out. The issue of reforming the socio-cultural sphere in the context of this bill was considered.
PRINCIPLES OF ADVOCACY THAT DETERMINE THE NATURE ACTIVITIES OF A LAWYER IN CIVIL PROCEEDINGS
Authors: Федина Анжелика Сергеевна
Published: July 2022

В правовой доктрине в систему принципов адвокатской деятельности включаются самые разные императивные директивы как общеправового характера, так и специальные, отраслевые. По мнению автора, в качестве основных принципов адвокатской деятельности, которые будут определять деятельность адвоката в гражданском процессе, надлежит особенно выделять принципы законности, добросовестности, профессиональной независимости, сохранения профессиональной тайны.

In the legal doctrine, the system of principles of advocacy includes a variety of imperative directives, both of a general legal nature and special, sectoral ones. According to the author, as the main principles of advocacy, which will determine the activities of a lawyer in civil proceedings, it is necessary to highlight the principles of legality, good faith of a lawyer, professional independence, and the preservation of professional secrecy.
SCIENTIFIC ANALYSIS OF THE LEGISLATIVE DEFINITION OF THE CONCEPT OF DIGITAL FINANCIAL ASSETS
Authors: Терехов Максим Геннадьевич
Published: July 2022

Поднимается вопрос о гражданско-правовой природе законодательного определения понятия «цифровые финансовые активы» в системе права России, которые, по мнению автора статьи, должны иметь более конкретизированную правовую конструкцию в гражданском праве.

The article raises the question of the civil turnover of objects representing value expression, which are used exclusively in the digital environment (the Internet).
Activities of English agents in central asia in the first half of the XIX century in the context of Russian-English rivalry
Authors: Suinova A.T. , Dyusembekova Zh.K.
Published: July 2022

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Informe Anual del Centro Colombiano de Datos Oceanográficos (Cecoldo) 2021
Authors: DIMAR Dirección General Marítima
Published: July 2022

Desde 2016 el Centro Colombiano de Datos Oceanográficos (Cecoldo) emite un informe anual para dar a conocer las actividades desarrolladas año tras año, los datos oceanográficos y de meteorología marina recuperados y catalogados; el establecimiento de compromisos de entrega periódica de datos; las contribuciones de datos abiertos a diferentes iniciativas académicas y científicas; la participación y aportes realizados en diferentes escenarios nacionales y regionales, y el compromiso con la difusión de la información y productos oceanográficos del país. El presente informe corresponde al séptimo número. En su primer capítulo describe campañas oceanográficas y expediciones científicas ejecutadas durante 2021, cuyos datos oceanográficos llegarán a hacer parte del Cecoldo. También se incluye una lista detallada de los datos entregados este mismo año por parte de los centros de investigaciones oceanográficas e hidrográficas y la Red de Medición de Parámetros Oceanográficos y de Meteorología Marina (RedMpomm) de la Dirección General Marítima (Dimar), para un total de 31 conjuntos de datos depositados y disponibles. En temas de gestión de datos, describe las actividades realizadas por parte del Cecoldo en su nuevo rol como responsable nacional del envío de datos para el indicador 14.3.1 de los objetivos de desarrollo sostenible (ODS), con un total de cinco conjuntos de datos enviados al portal del Programa para el Intercambio Internacional de Datos e Información Oceanográfica (IODE) de la Comisión Oceanográfica Intergubernamental (COI). En cifras, el Cecoldo nuevamente reporta un balance positivo en términos de acceso a datos e información; aunque la cantidad de solicitudes de acceso a datos no aumentó con relación al 2020, sí se observó un incremento del 20 % en el volumen de datos entregados y del 45 % en la cantidad de descargas de publicaciones técnicas y científicas disponibles en el Repositorio Digital Marítimo, Fluvial y Costero. Asimismo, se contribuyó con datos abiertos a 32 proyectos o iniciativas académicas y científicas de ciudadanos colombianos y extranjeros. Dando continuidad a las actividades interinstitucionales coordinadas desde el Cecoldo por conducto del Comité Técnico Nacional de Datos e Información Oceánicos (CTN Diocean), en 2021 se diseñó y editó la nueva publicación digital Boletín CTN Diocean, mediante la cual anualmente se darán a conocer las cifras de acceso a datos oceánicos proporcionadas por los sistemas de información nacionales, así como los aportes del país al resultado ‘Un océano accesible’ del Decenio de las Ciencias Oceánicas para el Desarrollo Sostenible 2021-2030, experiencias en buenas prácticas de gestión de datos y actividades de difusión y capacitación desarrolladas.
Pronóstico de pleamares y bajamares, y referencias verticales para los principales puertos de Colombia. No. 1, año 2022
Authors: Oviedo Barrero Fernando , Latandret Solana Sadid Augusto , Ruz Poveda Carlos Andrés , Figueredo Machuca Brenda , Álvarez Solarte Julián Libardo , Vásquez López Laura Marcela , Guerrero Castillo Anlly Melissa
Published: July 2022

El Pronóstico de pleamares y bajamares, y referencias verticales para los principales puertos de Colombia, reporta el análisis físico-matemático realizado a partir de los datos proporcionados por los mareógrafos de la Dimar, tales como el estudio de los coeficientes armónicos, determinación del factor de forma y clasificación del tipo de marea, análisis multizon a del comportamiento de marea y pronósticos de marea. Adicionalmente al tratamiento de los datos de la red mareográfica, la Dimar determina la superficie hidrográfica de referencia vertical (SHRV) para los principales puertos marítimos y sus zonas aledañas, producto que permite cuantificar la variabilidad de las mareas a lo largo de las costas Caribe y Pacífica. La Dimar crea, estandariza y mantiene la infraestructura de soporte para la SHRV, compuesta por las estaciones de observación mareográfica de permanente transmisión y la red de vértices geodésicos con sus carteras de metadatos espaciales, para el buen uso de los usuarios internos y externos que ejecuten actividades marítimas en las aguas jurisdiccionales y que involucren mediciones referidas a un determinado nivel o dátum de marea.
كارتێكرنا ساخله‌تێن به‌رزی ونزمیێ لسه‌ر دابه‌شبوونا داپووشێ دارستانان لده‌ڤه‌را چیایی یا پارێزگه‌ها دهوكێ
Authors: Ismail Dilovan Ramadhan , Ali Ahmed Hassan
Published: July 2022

به‌رزی ونزمی دێنه‌ هه‌ژمارتن فاكته‌رێن سه‌ره‌كی یێن كارتێكرنێ دكه‌نه‌ سه‌ر سیسته‌مێن ژینگه‌هی یێن جیاواز، هه‌روه‌كی كارتێكرنا وێ دیاردبیت لسه‌ر دابوشبونا رووه‌كان لسه‌ر روویێ ئه‌ردی. ئارمانج ژئه‌ڤێ ڤه‌كولینێ دیلركرنا كارتێكرنا ساخله‌تێن به‌رزی ونزمیێ نه‌ لسه‌ر دابه‌شبوونا داپووشێن دارستانان لده‌ڤه‌را چیایی یا پارێزگه‌ها دهوكێ ببكارئینانا داتایێن هه‌ستكرن ژدیر (Remote Sensing(RS)) وسیسته‌مێ پێزانینێن جوگرافی (Geographic Information System (GIS)). نموونا بڵنداهیا ئه‌ردی (Digital Elevation Model (DEM)) ژێده‌رێ سه‌ره‌كی یه‌ بو نوێنه‌راتیا ساخله‌تێن به‌رزی ونزمیێ (بڵنداهی، ولێژاتی، ولێژاتیا ئه‌ردی، سیبه‌را بڵنداهیا). نه‌خشه‌یێن داپووشێن دارستانان هاتینه‌ دروستكرن پشت به‌ستن لسه‌ر پولینكرنا چاڤدێریكری (Supervised Classification) بو وێنێن سه‌ته‌ڵایتی یا هه‌یڤا ده‌ستكردا ئه‌مریكی (Landsat_8) بو ساڵا (2021)ز دناف ژینگه‌ها به‌رنامێ (ENVI)دا. ئامیرێ پێكڤه‌گرێدانێ (Intersect) دبه‌رنامێ (ArcGIS) دا هاتیه‌ بكارئینان بو گرێدانا داپووشێن دارستانان دكه‌ل ساخله‌تێن به‌رزی ونزمیێ، ژبو مه‌ره‌ما دیاركرنا كارتێكرنا ساخله‌تێن به‌رزی ونزمیێ لسه‌ر دابه‌شبوونا دارستانان له‌ده‌ڤه‌را ڤه‌كولینێ. ده‌رئه‌نجامێن ڤه‌كولینێ دا دیار دبیت كو شێوازێ دابه‌شبوونا دارستانان لده‌ڤه‌را ڤه‌كولینێ دهێته‌ كارتێكرن بفاكته‌رێن به‌رزی ونزمیێ
Documenting Cityscapes. Urban Change in Contemporary Non‐ Fiction Film
Authors: Eduardo Barros-Grela
Published: July 2022

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El abrigo epipaleolítico de Peña 14 (Biel, Zaragoza). Excavaciones 1999 y 2000
Authors: Montes Lourdes
Published: July 2022

Se da cuenta de las dos campañas de excavación desarrolladas en el yacimiento de Peña 14.
Nuevos datos para la arqueología funeraria de Caesaraugusta: las tumbas paleocristianas de la calle Mosén Pedro Dosset (vial) (Zaragoza)
Authors: Galve Pilar , Blanco Alfredo
Published: July 2022

Se da cuenta de la excavación arqueológica en la necrópolis paleocristiana de la calle Mosén Pedro Dosset de Zaragoza.
Correlation Clustering with Overlaps. (c2020)
Authors:   ,   Lebanese American University, Fakhereldine Amin
Published: July 2022

The Cluster Editing problem asks for transforming a given graph into a disjoint union of cliques by applying a minimal number of edge-editing operations. The allowed operations include addition of non-existing edges and deletion of existing ones. We study a multi-parameterized version of the problem that limits the global number of allowed edge editing operations in the graph and the local amounts of the edge edits performed per vertex. Moreover, we allow the new vertex splitting operation, which allows the resulting clusters to overlap. In other words, data elements (or vertices) will be allowed to be members in more than one cluster instead of limiting them to only one single cluster, as in classical clustering methods. We present a heuristic algorithm and a semi-exact algorithm for the Multi-Parameterized Cluster Editing with Vertex Splitting problem. In our experimental analysis, we study the efficiency of our algorithms as well as the effectiveness of allowing vertex splitting. In particular, we show that allowing vertex splitting yields higher clustering accuracy and higher intra-cluster similarity.
Investigating the Therapeutic Effects of Small Molecule Imipridones In Pediatric Neuroblastoma. (c2020)
Authors:   ,   Lebanese American University, El Soussi Sarra
Published: July 2022

The small molecule inducers of TRAIL ONC201/TIC10 and its analog ONC206 exhibit anti-tumor activity by inhibiting AKT/ERK phosphorylation and causing early activation of the integrated stress response. They are reported to inhibit the DRD2 receptors and activate mitochondrial ClpP leading to apoptosis and reduced proliferation in various tumors. Neuroblastoma is the most common extra-cranial nervous system tumor in children that presents with a spectrum of clinical prognostic measures ranging from benign growths that regress spontaneously to highly malignant, treatment evasive tumors affiliated with high mortality rates. MYCN amplification renders this tumor highly malignant and recurrence prone. In our current study we report for the first time, a novel inhibition of EGF-induced L1CAM and PDGFRβ phosphorylation with either ONC201 or ONC206 treatment in human MYCN-amplified neuroblastoma IMR-32 and non-MYCN amplified SK-N-SH cell lines. Drug treatment in these cells significantly reduced cellular proliferation, viability, migration and increased apoptosis. Tumorsphere formation potential was further significantly reduced with either drug treatment in both cell lines with ONC206 exhibiting much higher potency. MYCN expression was significantly abrogated in the IMR-32 cell line with either drug treatment. The protein expression of Sox-2, Oct-4, FABP5 and HMGA1 was significantly reduced whereas cleaved PARP1 and caspase-3 and p-H2AX was increased 48 h after drug treatment in the MYCN-amplified IMR-32 cell line. We are the first to report this novel differential protein expression after ONC201 or ONC206 treatment in these cells. Our findings demonstrate an important multi-target effect of imipridones that may yield added therapeutic benefits in treating this devastating cancer.
Studying the moderating effect of entrepreneurial orientation on the positive relationship between cultural intelligence and opportunity recognition in the MENA region during the Covid19 pandemic. (c2020)
Authors:   ,   Lebanese American University, El Moussaoui Marwa
Published: July 2022

Entrepreneurs tend to recognize better opportunities when conscious and appreciative of either the Meta-cognitive or Cognitive cultural intelligence (CQ) dimensions. This exploratory research questioned whether individuals having an Entrepreneurial Orientation (EO) with its innovative, pro-active and risk-taking facets are better suited to use their Meta-Cognitive and Cognitive CQ capabilities in the recognition of opportunities in a culturally diversified context during the Covid19 pandemic. In other words, the main aim behind the present study was to determine whether EO moderates positively or negatively the relationship of Meta-Cognitive CQ-OR and Cognitive CQ-OR. Based on a sample of 515 observations from the MENA region, results showed that there was a strong relationship between the Meta-Cognitive dimension of CQ and Opportunity Recognition and the Cognitive dimension of CQ and Opportunity Recognition (OR). These two positive relationships were both moderated one positively (Cognitive CQ-OR) and the other negatively (Meta-Cognitive CQ-OR) by Entrepreneurial Orientation (EO).
Evaluation of light-activated Ru(II) prodrugs and their photoproducts as potential anti-cancer agents. (c2020)
Authors:   ,   Lebanese American University, Elias Maria
Published: July 2022

Photoactivated chemotherapy (PACT) has emerged as a new method for targeted cancer therapy. Strained ruthenium based complexes with octahedral geometry may undergo ligand dissociation once irradiated, forming aquated photoproducts that are greatly cytotoxic compared to their prodrug complex. The current study evaluates light-activated ruthenium prodrugs and their photoproducts as potential anti-cancer agents. The complexes being investigated are: [Ru(bpy)2phen]Cl2 (unstrained), [Ru(bpy)2BC]Cl2, [Ru(bpy)2dpphen]Cl2. Both strained complexes showed a 𝜆max≅ 450 nm in the visible range, accordingly, blue LED light (460 nm) was used for their photoactivation. [Ru(bpy)2BC]Cl2 was synthesized, purified and characterized by NMR and investigated for its mechanistic potential against cancer. The aquated photoproduct of [Ru(bpy)2dpphen]Cl2 was purified, characterized using ESI/MS and NMR, and shown to be essential for the exhibited toxicity when its prodrug and light irradiated complex were tested on human melanoma (A375) cancer cells. The uptake of [Ru(bpy)2BC]Cl2, assessed by ICP/MS, started immediately post incubation and plateaued after 24 hours. The uptake was mainly attributed to occur via active transport. Cytotoxicity assays on A375 showed a mean phototoxicity index of 340 at 72 hours, presenting the intracellular aquated photoproducts being effective rather than the dissociating ligands. A significant increase in ROS production and DNA damage was also observed. Flow cytometry results revealed the induction of apoptosis. Western blot analysis of pro- and anti-apoptotic protein revealed apoptosis to be mediated through both intrinsic and extrinsic pathways, as well as via inhibition of the MAPK and PI3K pathways. [Ru(bpy)2BC]Cl2 (with and without photoactivation), and [Ru(bpy)(dpphen)H2O]Cl2 were also investigated for their in vivo anticancer activity using a 7,12-Dimethylbenz[a] anthracene/12-O-Tetradecanoylphorbol 13-acetate skin carcinogenesis mice model. All complexes reduced significantly tumor growth 3 weeks post treatment when compared to non-treated mice. In conclusion, this study demonstrates that [Ru(bpy)2BC]Cl2 is a multi-mechanistic PACT drug which exhibits promising in vitro and in vivo anti-cancer potentials. It also reveals that [Ru(bpy)(dpphen)H2O]Cl2, the aquated form of [Ru(bpy)2dpphen]Cl2 photoproduct, has in vitro and in vivo anticancer activity and could be used as a chemotherapeutic agent.
The mediating effect of Work Engagement on the relation between Career Adaptability and OCB.
Authors:   ,   Lebanese American University, Hadla Fatima
Published: July 2022

Employees are the asset of every organization. They are the resource that grant the organization a competitive advantage in the market place. Due to fast changes taking place in today’s market, organizations are relying more on employees with higher work engagement level, adaptability and the willingness to go the extra mile. This study explores the relationship between career adaptability and organization citizenship behavior (OCB). It also proposes the mediation of work engagement between career adaptability and OCB. One hundred and forty employees working in the private sector in Lebanon participated in our survey that was then analyzed using SPSS and PROCESS software. Results indicated that career adaptability has significant positive influence on OCB and work engagement, work engagement in turn is positively associated with OCB and acted as a partial mediator for career adaptability and OCB. Furthermore, future recommendations and practical implications of the study are discussed along with limitations.
Life Cycle Assessment of Wastewater Treatment Plant Varying Electricity Power Sources. (c2020)
Authors:   ,   Lebanese American University, Nassar Dina
Published: July 2022

Wastewater treatment is an essential life process that enhances water quality as population and urbanization are increasing proportionally. The increase in population alongside the increase of wastewater treatment plants’ significance, lead to an increase in electricity demand to power the plants. All the mentioned factors together spell negative impacts on the environment that need to be mitigated urgently. Applying a life cycle assessment (LCA) for the process becomes essential. This study evaluates the LCA of a wastewater treatment plant in Nabatieh, South Lebanon. The studied treatment includes a preliminary stage, an oxidation ditch, and UV disinfection. The plant is powered by a source that is solely dependent on diesel combustion. The assessment is conducted using the software SimaPro 9.0 following ISO 14040 standards. Using CML-IA method several impact categories studied such as abiotic depletion of fossil fuels, global warming, and abiotic depletion of material in general. As a result, electricity showed the highest contributing factor on most of the impact categories. Moreover, the most affected category was the global warming. To reduce this impact, several scenarios were considered for powering the plant. The scenarios include alternative combinations of renewable (solar, wind, and hydroelectric energy) and non-renewable (natural gas, crude oil, and biomass) energy sources. Five different alternatives were compared. Result comparison showed that the scenario that depends on 53% fossil fuels, 45% several renewable energy sources, and 2% biomass, has the most enhancement on the most affected category which is the global warming and several others. However, due to renewable sources’ initial demand of material, it showed a deterioration in the effect of the abiotic depletion of material category. Also, other categories, such as freshwater ecotoxicity, were affected by the construction phase and wastes disposed during the transition to renewable energy sources. This interpretation is considering the environmental impact without the economic aspect. When introducing the economic aspect, the same scenario is the most expensive and costly one. This paper does not give a conclusive optimal solution, considering the Lebanese economic situation, yet it shows that it is possible to reach an improvement of 80% and more in certain sectors when introducing renewable energy sources.
An Optimized Influencer Rating Model using a Joint Event and Theme based Approach. (c2020)
Authors:   ,   Lebanese American University, Srour Ali
Published: July 2022

The continuous development of social media platforms and exponential level of users' engagement are playing a key role in turning social media platforms into a data source that is indispensable for understanding the behavior of people. Yet this comes along with all types of challenges that needs efficient solutions and big data analysis techniques to allow capturing the different dimensions evolving over social media. Moreover, the importance of detecting influencers over social media platforms has become one of the most challenging research topics given that influencers are at the core of decision-making strategies and leading events' directions on Social Media. Generally, determining influencers can increase revenue and utility; however, measuring the influence of users is essential for determining influencers. Influencers should be credible, reliable, trustworthy, knowledgeable in the domain being discussed and have a high impact that derives people's opinions and lead them towards the proper decisions. However, influencers might play different roles when speaking about misinformation and conspiracy during sensitive and trending event. While different techniques were developed to select influencers over social networks, identifying influencers remains an evolving topic due to the dynamic nature of the social media users and use in addition to their extremely increasing growth which attracts high research interests across multiple disciplines including data science, psychology, sociology, and different human sciences all of which have been studying the topic from multiple angles. In this thesis, we further aim at identifying influencers through proposing influence rates calculation mechanism to find real and highly influential users at a certain event over Twitter using a mixed theme and event base approach with an emphasis of maximizing accuracy calculation by integrating historical influence rates in addition to content and profiles reputation. We further apply our approach on a global pandemic, the novel Coronavirus, and then we provide results and performance analysis. Finally, we conclude our work by summarizing our major findings and discussing future work.
Hubungan Gaya Hidup Pasien Laki-Laki Terhadap Kejadian Hipertensi di Puskesmas Kuta Makmur
Authors: Zuryani Ulfa , Zara Noviana , Ikhsan Ridhalul
Published: July 2022

Hipertensi sangat dipengaruhi oleh gaya hidup yang tidak sehat. Ada beberapa hal yang dapat menyebabkan terjadinya hipertensi diantaranya kebiasaan merokok, aktivitas olahraga dan pola makan. Tujuan penelitian ini untuk mengetahui hubungan gaya hidup pada pasien laki-laki terhadap kejadian hipertensi. Jenis penelitian ini merupakan deskriptif analitik dengan pendekatan cross sectional. Jumlah sampel sebanyak 50 orang yang memenuhi kriteria inklusi dan eksklusi. Analisa data menggunakan uji chi square. Hasil penelitian ini didapatkan bahwa terdapat hubungan antara merokok dengan pasien hipertensi dengan nilai p value=0,012, terdapat hubungan antara olahraga dengan pasien hipertensi dengan nilai p value=0,002 dan terdapat pula hubungan antara pola makan dengan pasien hipertensi dengan nilai p value=0,000. Kesimpulan penelitian ini adalah terdapat hubungan antara gaya hidup pada pasien laki-laki terhadap kejadian hipertensi di Puskesmas Kuta Makmur pada tahun 2019.