bluuebunny/crossref_metadata_2025 huggingface dataset:
Acanthosis nigricans maligna
Authors: Gross G. , Pfister H. , Hellenthal B. , Hagedorn M.
Published: October 2009

2 cases of acanthosis nigricans associated with an adenocarcinoma (signet ring cell carcinoma) of the stomach and a metastasizing small-cell carcinoma of unknown origin are reported. In both cases the skin lesions preceded the diagnosis of the carcinoma by months and acanthosis nigricans maligna was suspected by onset and localization of the dermatosis. There was no evidence of a papillomavirus etiology of the warty skin lesions. Virus particles could not be demonstrated either in ultrathin sections or in buffer extracts. Virus-specific DNA was not detectable after CsCL-ethidium bromide gradient centrifugation and cellular DNA did not hybridize under stringent or relaxed conditions with 32P-labelled human papillomavirus 6 or human papillomavirus 8 DNA.
A Clinical Profile of Donovanosis in a Non-Endemic Area
Authors: Sehgal V.N. , Shyam Prasad A.L.
Published: October 2009

The diagnosis of donovanosis is seldom made in a non-endemic region, because it is usually overlooked as an aetiologic diagnosis of genital ulcers. Clinical suspicion is a yardstick in its diagnosis and has been illustrated in the present study. Its frequency was found to be 3.14% of all sexually transmitted diseases. Unmarried males of vulnerable sexual age were commonly affected. They came from a low socioeconomic strata. The incubation period and duration of disease was variable. The genitalia were primarily affected. The ulcerogranulomatous variety was seen commonly, though unusual expression of the disease was also recorded. The importance of repeated tissue smears and/or histopathology in certain clinical variants is emphasized.
Fume Inhalation Chloracne
Authors: Sehgal V.N. , Ghorpade A.
Published: October 2009

Chloracne in a factory worker manufacturing sodium pentachlorophenate, triggered by inhalation of fumes, is reported.
A Case of Chronic Urticaria and Vitiligo, Associated with Thyroiditis, Treated with PUVA
Authors: Midelfart Kjell , Moseng Dagfinn , Kavli Gunnar , Stenvold Svein Erik , Volden Gunnar
Published: October 2009

A case of chronic urticaria and vitiligo, associated with thyroiditis is described. Significantly elevated thyromicrosomal antibodies were found. Autoimmune reaction is a possible cause of the patient’s thyroid disease, vitiligo and chronic urticaria. Following PUVA treatment with a total dose of 300 J/cm2 the patient’s urticaria subsided in all irradiated areas, only to relapse 2 weeks later. Subsequently courses of PUVA gave periods of remission. The treatment also induced repigmentation in the vitiliginous spots. The results indicate a local PUVA effect upon mediators or mediator-containing cells.
Cutaneous Cytodestructive Potency of Lignans
Authors: von Krogh Geo , Maibach Howard I.
Published: October 2009

Four lignans: podophyllotoxin (A), 4′-demethyl-podophyllotoxin (B), α-peltatin (C), and β-peltatin (D) are the podophyllin ingredients producing lesional necrosis after application on condylomata acuminata. This study evaluates comparatively their destructive potency on rabbit skin after 10-day repeated applications. Any visible changes or increase on skinfold thickness induced by each of the drugs tested as 0.01 0.05, 0.1 and 0.5% ethanolic preparations were followed. These variables demonstrated a close covariation; the analyses revealed a significant difference with respect to influence on measurements according to the following ranking order: A > C > D = B.
Surinfection par Aspergillus de brûlures graves
Authors: De Maubeuge J. , Song M. , Juvent M. , Ley R. , Achten G.
Published: October 2009

Aspergillus, which has a saprophytic life, is an opportunistic fungus and manifests his pathogenicity when a weakened state of the host facilitates its development. The conditions are particularly favorable in severely burned patients like the 54-year-old woman presented here. The criteria of pathogenicity of this opportunistic fungus, the incidence of epidemiology and prognosis of this type of infection and the clinical signs that allow an early diagnosis are discussed here.
Genetic Counseling for Skin Diseases
Authors: Hashimoto Isao , Katabira Yasuo , Sugawara Mitsuo , Hanada Katsumi , Sato Shizuo , Hada Tomoko , Nomura Kazuo , Mitsuhashi Yoshihiko , Kawamura Yoshiko
Published: October 2009

A statistical study was carried out on 182 cases who seeked out genetic counseling about skin diseases. The size of the latent demand for the counseling was assessed to be as much as 3.0% of the outpatients. Most clients were in their twenties. A representative consultand was the patient’s child or sibling. The main deseases in question were cleft lip and palate (16%), nevus pigmentosus (12%), Recklinghausen’s diseases (8%) and psoriasis (8%). Estimation of the recurrence risk was impossible in 3%, approximate in 54% and accurate in 43%. This defective estimation is due to the insufficiency of the available genetic data, e.g. carrier frequency, penetrance rate, contraction rate by age, etc. The high-risk cases were found to be 36%. In 9 cases (5% of all the counselings) the client decided to avoid reproduction. In 30 cases (16%), the clients asked for counseling after having conceived or given birth to a consultand. They were thought to be too late from the standpoint of prophylaxis of inherited diseases. Our conclusion is that genetic counseling offers some measure of disease prevention and therefore will become an essential branch or dermatology in the future.
Cultural Proof of Neisseria gonorrhoeae in Synovial Fluid in Disseminated Gonococcal Infection
Authors: Korting H.C. , Abeck D. , Neubert U.
Published: October 2009

Disseminated gonococcal infection is not too rare, and joint involvement is one of its prominent features. Although diagnosis in general is based on clinical findings and microbiological examination of the genitals and sometimes blood, there are cases in which exact diagnosis can only be made after the investigation of synovial effusion. An observation of this kind is presented, and the general value of the aspiration of synovial fluid in disseminated gonococcal infection is discussed. Special interest is also given to the possible coincidence of disseminated gonococcal infection and other sexually transmitted diseases as for example trichomoniasis, both of which were found in our case.
Traitement par acyclovir d’un eczema herpeticum compliquant une maladie de Darier
Authors: Leroy D. , Pedailles S. , Maillard V. , Freymuth F. , Talec R. , Deschamps P.
Published: October 2009

This paper describes two episodes of eczema herpeticum occurring in a woman with Darier’s disease. During the first episode, the vesicular eruption represented a primary herpetic infection because there were no IgM herpes antibodies. The second attack suggested a recurrent infection. Herpes simplex, virus type I was isolated from the lesions in both cases.
Bowen’s Disease of the Nail Bed
Authors: Nogita Toshitatsu , Ohyama Katsuro , Ono Tomomichi
Published: October 2009

A 61 -year-old Japanese man with Bowen’s disease of the nail bed of the left great toe was reported. Amyloid deposits were present in the papillary dermis. Excision and skin grafting were beneficial.
Alopecia ichthyotica
Authors: Traupe Heiko , Happle Rudolf
Published: October 2009

Scarring patchy alopecia is a characteristic feature of various forms of congenital ichthyosis (congenital ichthyosiform erythroderma). 4 patients presenting this scalp disease are described. The hair loss is obviously a consequence of the ichthyosiform erythroderma, and therefore we propose for this type of pseudopelade the term alopecia ichthyotica.
Clinical Experience on the Treatment of Alopecia areata with Squaric Acid Dibutyl Ester
Authors: Giannetti A. , Orecchia G.
Published: October 2009

Squaric acid dibutyl ester was used in the treatment of 26 cases of alopecia areata (AA). The results are related to different types of AA.
Direct Immunofluorescence in Recurrent Aphthous Ulcers and Behçet’s Disease
Authors: Reimer G. , Luckner L. , Hornstein O.P.
Published: October 2009

Direct immunofluorescence (IF) investigations in oral aphthae were performed in 17 patients with recurrent aphthous ulcers (RAU) and in 9 patients with Behçet’s disease (BD). In addition, cutaneous hyperreactivity lesions from 2 BD patients were examined. The results were compared to direct IF findings in 28 patients with nonaphthous oral diseases. There was no difference between direct IF on oral aphthae in RAU compared to BD. Deposition of C3 in vessel walls of the subepithelial connective tissue was observed in 13 of 17 patients with RAU and in all patients with BD. IgM deposits in vessel walls were found in 5 RAU and 3 BD patients. Deposition of C1q or C4 was not present. By contrast, IgG and/or IgM, C1q, C3 and C4 were detected in dermal vessel walls of skin hyperreactivity lesions from 2 BD patients. This finding is considered to be a true immune complex vasculitis. Compared to nonaphthous oral lesions, oral aphthae of BD and RAU were characterized by C3 deposition in the subepithelial vessel walls.
Blue Rubber Bleb Nevus Syndrome
Authors: Munkvad M.
Published: October 2009

A case and the family pedigree with the dominant genodermatosis blue rubber bleb nevus syndrome (BRBNS) are described. It is shown that the mode of inheritance is autosomal dominant with good penetrance and that the affected individuals examined all are healthy apart from the skin disease.
Coincidence of Primary Malignant Melanoma of Skin and Eye
Authors: Korting H.C. , Blick U. , Hamperl W.-D.
Published: October 2009

Although primary malignant melanomas of the skin or eye alone are not too rare, their coincidence is most uncommon. The case of a 41-year-old Caucasian male is reported who developed superficially spreading melanoma on the skin of his trunk 9 years after the enucleation of his right eye because of a fusiform melanoma of the choroidal membrane. Staging revealed a further malignancy: hemangiopericytoma inside and adjacent to the left psoas muscle. Both theoretical and practical conclusions to be drawn from the case are discussed.
Keratoacanthoma Arising in Stasis Dermatitis
Authors: Harari Z. , Zaidel L.
Published: October 2009

A case of keratoacanthoma arising in stasis dermatitis is presented. The eczematous dermatitis was aggravated by episodes of deep tissue inflammation, yet the common course of the tumor was not altered. To our knowledge, this is the first report of a keratoacanthoma arising in stasis dermatitis.
Das «Pilar Sheath Acanthoma» – ein gutartiges follikuläres Hamartom
Authors: Smolle J. , Kerl H.
Published: October 2009

A new case of pilar sheath acanthoma is reported. This tumor has been identified in 1978 and shows characteristic histological features: a central sinus with keratinous material, a pore-like opening to the surface, keratinization of the epidermoid type and projecting epithelial tumor lobes containing small keratin cysts resembling incomplete pilar differentiation.
Multilobated Cutaneous T Cell Lymphoma
Authors: Toonstra J. , van der Putte S.C.J. , Kalsbeek G.L.
Published: October 2009

2 middle-aged men are described with slowly progressive papular and nodular lesions, limited to the skin of the back. Clinically and histologically both resembled Crosti’s reticulosis (‘réticulo-histiocytome du dos de I’adulte’). It was determined by electron microscopic, enzyme cytochemical and immunological studies that the ‘histiocyte’ component, which was derived from T lymphocytes, consisted of blast-like cells with characteristic multilobated nuclei with nucleoli in marginal position. For this type of lymphoma, which may have been described previously as lymphocytoma cutis or reticulum cell sarcoma, the term ‘multilobated cutaneous T cell lymphoma’ is proposed. According to its slowly progressive clinical course it may be classified as a malignant lymphoma of low grade malignancy.
Retinoid-orale Photochemotherapie (RePUVA) als Kombinationsbehandlung bei Mycosis fungoides
Authors: Hunziker T. , Zala L. , Krebs A.
Published: October 2009

We report the impressive result obtained by the additional oral administration of an aromatic retinoid in a patient with mycosis fungoides who developed new infiltrative lesions during continuous oral photochemotherapy.
Comparison between Plasma Levels of 8-Methoxypsoralen and Skin Photosensitivity: The Interest of Pharmacokinetic Studies during Photochemotherapy of Psoriasis
Authors: Beani J.C. , Sarrazin C. , Amblard P. , Reymond J.L. , Beriel H. , Boitard M.
Published: October 2009

The present work compares the time course of 8-methoxypsoralen (8-MOP) plasma levels with that of induced skin photosensitivity. The value of plasma assay as a reflexion of cutaneous concentration of 8-MOP has been definitively demonstrated. This study also shows the importance of pharmacokinetics in the therapy management of ‘poor responders’ to PUVA.
Effect of Vitamin A Acid on Homeostasis and Differentiation of Epidermal Cells Cultured on Collagen
Authors: Mahrle Gustav , Gray Barbara
Published: October 2009

Cultured guinea pig epidermal cells were treated with vitamin A acid (VA; 2, 5, 10 μg/ml) and controlled by autoradiography and histochemical methods. Cells attached to the bottom of the plates were counted and their number correlated with the number of cells sloughed off into the medium (A/D ratio). VA reduced the size of multilayered cell colonies, favoured cell spreading and accelerated confluence. It altered the mode of shedding since the cells sloughed off into the medium as isolated cells rather than cell complexes, as in untreated controls. It increased the A/D ratio in early cell cultures and decreased the A/D ratio in late cell cultures. The higher the concentration of VA, the earlier and more prominent was the decrease of the A/D ratio. Low concentration of VA (2 μg/ml) given once at seeding favoured the formation of keratohyalin and cornifíed envelopes whereas high concentrations (5, 10μg/ml) given continuously prevented their formation and caused mucoid vacuolar degeneration of single cells. VA inhibited complete keratinization in all cases, but appeared to allow pre-keratinization, particularly at low concentrations. The results indicate that VA controls epidermal homeostasis in vitro by its influence on both proliferation and shedding. Its effect on the markers of differentiation is heterogeneous since it prevented keratinization in every case, but induced keratohyalin formation under certain conditions.
Persistent Ashen-Gray Maculae and Freckles Induced by Long-Term PUVA Treatment
Authors: Kanerva L. , Lauharanta J. , Niemi K.-M. , Juvakoski T. , Lassus A.
Published: October 2009

Persistent ashen-gray maculae 5–7 mm in diameter and freckles developed after prolonged PUVA therapy of psoriasis. Histopathology of maculae showed extensive collections of melanophages in the upper dermis. The melanocytes were strongly stimulated at the site of the freckles. The number of melanosomes, mitochondria, endoplasmic reticulum and dendrites were increased. Pathological features such as large amounts of lipid droplets and lysosome-melanosome complexes were also found within the melanocytes.
Generalised Pustular Psoriasis, Psoriatic Arthritis and Nephrotic Syndrome Associated with Systemic Amyloidosis
Authors: David M. , Abraham D. , Weinberger A. , Feuerman E.J.
Published: October 2009

The case report is presented of a psoriatic patient with arthropathy, generalised pustular psoriasis and nephrotic syndrome, in whom systemic amyloidosis developed. The literature reports 13 cases of psoriasis associated with amyloidosis, 3 of whom suffered from pustular psoriasis as does our case. With the addition of our case, 12 of these 14 had concomitant arthropathy. This seems to suggest that arthritis is an important factor in the appearance of amyloidosis. Rectal biopsy and/or renal biopsy may be helpful in establishing the diagnosis of amyloidosis relatively early in patients with psoriatic arthritis.
Cimetidine versus Placebo in the Treatment of Psoriasis
Authors: Wallach D. , Cottenot F.
Published: October 2009

A 2-month, double-blind, placebo-controlled clinical trial was undertaken to evaluate the effectiveness of cimetidine in the treatment of chronic, plaque-type psoriasis. 24 patients completed the trial (11 treated with cimetidine, 13 with placebo). 3 patients in the cimetidine group and 10 in the placebo group improved. This difference is significant (p < 0.01). Cimetidine had to be discontinued in 2 patients because of side effects. In this study, cimetidine proved of no benefit in the treatment of psoriasis. Furthermore, our results suggest the possibility of an adverse effect of cimetidine in psoriasis.
Severe Herpes Simplex Infection in Diffuse Histiocytic Lymphoma Treated with Adenine Arabinoside
Authors: Salomon F. , Sidi Y. , Garfinkel D. , Pinkhas J.
Published: October 2009

After 10 days of treatment with intravenous adenine arabinoside, complete healing of a severe labial herpes simplex infection was achieved in a patient with disseminated histiocytic lymphoma.
Histiocytosis-X cutanée de l’adulte
Authors: Bourlond A. , Defresne C. , Adam C. , Dereume J.L. , Vray M. , Dewael R.
Published: October 2009

2 cases of histiocytosis-X of the adult are reported. Localization in the axillary and inguinal folds and longitudinal shallow ulcerations look rather typical.
Histopathology of Pityriasis rosea Gibert
Authors: Panizzon Renato , Block Peter H.
Published: October 2009

62 biopsies of 40 patients with pityriasis rosea Gibert (PRG) were analyzed qualitatively and quantitatively. The main histopathological feature is eczematoid. In addition, the following characteristics, especially in combination, are helpful for the differential diagnosis: absence or decrease of the granular cell layer, erythrocytes in the papillary dermis and partly in the epidermis, and homogenization of the collagen of the papillary dermis. Recent and older lesions show little difference although the number of eosinophils in the inflammatory infiltrates has generally increased.
Etude clinique et histologique de l’effet d’un rétinoïde aromatique Ro 10-9359 sur un syndrome apparente à l’acrokératose paranéoplasique de Bazex
Authors: Le T. , Pierard G.E.
Published: October 2009

A 67-year-old man who had a pulmonary epidermoid carcinoma developed many paraneoplastic syndromes: acrokeratosis paraneoplastica with dermal mucinosis, hypertrophic osteoarthropathy and neuropathy. Treatment with RO-10-9359 improved some cutaneous paraneoplastic signs.
Influence of Retinoid Ro 10-9359 on Cell-Mediated Immunity in vivo
Authors: Fulton R.A. , Souteyrand P. , Thivolet J.
Published: October 2009

26 patients with psoriasis and 23 patients with other dermatoses were treated for 28 days with oral retinoid Ro 10-9359. Intradermal tests to seven recall antigens were carried out before and after therapy. Dinitrochlorobenzene (DNCB) sensitization was started at the initiation of retinoid therapy and challenge tests made after 28 days. There was a significant increase in the reactions to recall antigens in all groups after 28 days’ retinoid therapy. The reaction to DNCB was increased only in the non-psoriatic group compared with controls. These results demonstrate that the retinoid Ro 10-9359 stimulates cell-mediated immunity in vivo.
Pancreatic Exocrine Function in Rosacea
Authors: Barba Annalisa , Rosa Bianca , Angelini G. , Sapuppo A. , Brocco G. , Scuro L.A. , Cavallini G.
Published: October 2009

As some rosacea patients complain of gastrointestinal troubles and the administration of pancreatic extracts ameliorates both dyspepsia and skin lesions, the pancreatic exocrine function in 21 subjects affected with rosacea has been investigated by means of the secretin-cerulein infusion test. 21 healthy controls have been studied for comparison. No difference was found between rosacea and control subjects for flow rate, bicarbonate and chymotrypsin concentration and output, while lipase concentration and output was significantly lower in rosacea patients, with a decrease ranging from 18.5 to 66% of normal values. Therefore, a deficient lipase secretion could be responsible, at least partly, for the clinical manifestations of rosacea.
Syndrome de Werner
Authors: Defresne C. , Adam C. , Temmerman Saussez-De
Published: October 2009

A typical case of Werner’s syndrome is described in whom all the signs are present, with the exception of the consanguinity of the parents.
Rare Cases of Porphyria cutanea tarda Associated with Additional Iron Overload
Authors: Ivanov E. , Adjarov D. , Kerimova M. , Naidenova E.
Published: October 2009

Three rare cases are reported with porphyria cutanea tarda associated with additional iron overload – a relapse following blood transfusions, a combination with hemophilia A with massive hemorrhages and blood transfusions, and a combination with β-thalassemia. Successful treatment was carried out with phlebotomy and desferal. The role of iron overload in the pathogenesis of the disorder is discussed.
Electron Microscopic Observations of Arsenical Keratosis and Bowen’s Disease Associated with Chronic Arsenicism
Authors: Ohyama Katsuro , Sonoda Kuninobu , Kuwahara Hiroshi
Published: October 2009

A 57-year-old man, who had received injections of an arsenide for the treatment of syphilis, developed a tumor on his lower lip and a patchy pigmented lesion on his neck 2 years before the present examination. The lesions enlarged progressively. Under a diagnosis of arsenical keratosis and Bowen’s disease associated with chronic arsenicism, light and electron microscopic observations were made of the lesions. Vacuolated cells were demonstrated by light microscopy, while the characteristic electron microscopic features of both lesions were the appearance of nuclear bodies and the presence of radially arranged, intranuclear inclusion bodies of high electron density.
Double-Blind Evaluation of a Miconazole – Benzoyl Peroxide Combination for the Topical Treatment of Acne Vulgaris
Authors: Degreef H. , Vanden Bussche G.
Published: October 2009

The results of a randomized double-blind study show that benzoyl peroxide 5% combined with miconazole nitrate 2% in a cream formulation brought about a good to excellent result in 88% of 51 patients with moderate to severe acne, compared with benzoyl peroxide 5% alone which gave improvement in 41 % of 51 comparable patients. The difference is highly significant. Moreover, the frequency of the well-known irritating and drying effect of benzoyl peroxide was shown to be reduced from 10 cases in the benzoyl peroxide group to only 1 case in the miconazole/benzoyl peroxide-treated group. The combination of miconazole nitrate 2% and benzoyl peroxide 5% may therefore offer an effective and well-tolerated alternative to available therapies in the treatment of acne vulgaris.
Two Years’ Experience with Tigason Treatment of Pustulosis palmo-plantaris and Eczema keratoticum manuum
Authors: Reymann Flemming
Published: October 2009

The results are presented of 2 years’ experiments with Tigason® treatment of pustulosis palmo-plantaris (19 patients) and eczema keratoticum manuum (15 patients). These two skin diseases are characterized by being extremely resistant to conventional dermatological therapy, but responding immediately to treatment with Tigason. The rather high frequency of side-effects of the drug (dryness of mucosae, loss of hair, etc.) complicates the treatment but in about 50% of patients continuous or intermittent treatment over several years proved to be really beneficial.
Rapid Laboratory Diagnostic of X-Linked Ichthyosis
Authors: Meyer J.C. , Groh V. , Giger V. , Weiss H. , Varbelow H. , Schnyder U.W.
Published: October 2009

Steroid sulfatase and aryl sulfatase C activities were assayed simultaneously in peripheral blood leucocytes of 4 patients with X-linked ichthyosis (XLI) and 4 patients with autosomal-dominant ichthyosis; 11 healthy subjects served as controls. The deficiency of steroid sulfatase as well as of aryl sufatase C found in leucocytes of patients with XLI was confirmed by the histochemical demonstration of aryl sulfatase C deficiency in skin sections. Although results are obtained earlier with the histochemical method than with the biochemical assay in leucocytes, several disadvantages brought us to the conclusion that the biochemical assay of microsomal sulfatase activity in leucocytes offers a fast and safe method for the identification of patients with XLI.
Effects of Retinyl Acetate in Soluble and Encapsulated Forms on Epidermal Cell Proliferation in the Guinea Pig
Authors: Pullmann H. , Steigleder G.K.
Published: October 2009

Depending on the form in which the retinyl acetate is present in the emulsion there are differences in the degree of epidermal cell proliferation in the ear skin of the guinea pig. The ‘soft encapsulated’ form of retinyl acetate appeared to be less effective than either the ‘hard encapsulated’ form or the ‘ free’ water-soluble retinyl acetate.
Psoriasis et pemphigoïde
Authors: Olmos L. , de Diego V.
Published: October 2009

Description of a 40-year-old woman who had clinical and histopathological features of psoriasis and bullous pemphigoid. The comparison of our case to others described in the literature excludes any etiopathogenetic relationship between psoriasis and bullous pemphigoid.
Fibrome desmoïde – Transformation en fibrosarcome
Authors: Lowy M. , Lejeune F. , Heimann R. , Achten G.
Published: October 2009

Report of a case of aggressive musculo-aponeurotic fibromatosis in a 14-year-old girl with transformation into fibrosarcoma, 10 years later. The tumoral mass initiated its growth in the nucal region but finally invaded both the cervical and the right retroscapular region. Evidence for muscular, osseous and neurological invasion and destruction was found. The tumor could be controlled neither by surgery, nor by radiotherapy and chimiotherapy. This case report is studied in the light of cases reported in the literature.
Drugs Causing Fixed Drug Eruptions
Authors: Shukla S.R.
Published: October 2009

30 cases of fixed drug eruptions were investigated for their causative drugs. The clinical picture of the cases was classical. The results were confirmed by provocation tests. Analgesics and tetracyclines were found to be the most common offenders. Oxyphenbutazone was the next in the list.
The Effect of Beta-Carotene in Combination with Canthaxanthin, Ro 8–8427 (Phenoro®), in Treatment of Polymorphous Light Eruptions
Authors: Suhonen Raimo , Plosila Mikko
Published: October 2009

50 patients with polymorphous light eruptions were treated with a β-carotene-canthaxanthin combination, Ro 8–8427 (Phenoro®) at a daily dose of 100 mg or placebo for a duration of 10 weeks in a double-blind, randomized, cross-over trial. The effect of treatment was evaluated clinically on the basis of occurrence of pruritus, erythema and eruptions as well as subjectively through the patients own opinion about the condition of their skin. Excellent results after treatment with Ro 8–8427 were achieved in 27 cases and good results in 9, regardless of whether this preparation was the first treatment or the second. The corresponding figures after placebo were 16 and 12, respectively. Similarly, moderate results were achieved in 6 cases after Ro 8–8427 and in 9 cases after placebo. Poor results were achieved in only 3 cases after Ro 8–8427 as compared with 8 after placebo. Only a few, mild side effects were observed during the treatment periods.
Photochemotherapy of Psoriasis
Authors: Burger P.M. , Tijssen J.G.P. , Suurmond D.
Published: October 2009

PUVA therapy was administered to 140 patients with psoriasis. The results of clearing and long-term maintenance treatment are reported. Clearing requirements were in general similar to those reported by Melski and co-workers. The skin of a majority of the patients (79%) could be kept in a good condition by a maintenance-treatment schedule of once every 2 weeks or less. This result is better than the results reported by other authors. Extra topical treatment for residual lesions during maintenance consisted of small amounts of corticosteroids. The maximum length of the treatment intervals during maintenance showed definite individual variations. Patients who required one treatment a week or more to keep the skin cleared were dropped from the study.
Le syndrome de Lyell
Authors: Kint A. , Geerts M.L. , de Weert J.
Published: October 2009

In Lyell’s disease different clinical patterns can be observed: (a) an acute scarlatiniform erythema, on which more or less extended bullae rapidly appear; (b) a morbilliform erythema, with bullae; (c) the dermatosis can start under the features of an erythema exsudativum multiforme; (d) the eruption may begin as a psoriasis pustulosa. From an internal point of view, disturbances of the liquid balance and the blood electrolyte level may appear as a consequence of the important loss of water and serum. Toxic hepatitis, nephritis or myocarditis are possible complications. The origin of the disease is toxic or bacterial. This differentiation is important because the prognosis is much more favorable when the origin is bacterial than when the disease is due to medicines. A differential diagnosis between both etiologies may be achieved by histological examination: when the origin is a toxic one, we can find subepidermal blisters, while the blisters are located under the horny layer when the disease is of bacterial origin. The disease process is not clear in the toxic form. In cases induced by staphylococci, the epidermal lesions are caused by an epidermolytic toxin. The treatment will especially tend to restore the fluid and electrolyte balance; if there is a bacterial etiology, antibiotics will be necessary. Corticoids are to be avoided.
Kaposi’s Sarcoma after Steroid Therapy for Pemphigus foliaceus
Authors: Ilie B. , Brenner S. , Lipitz R. , Krakowski A.
Published: October 2009

Rapid evolution of Kaposi’s sarcoma terminating in death, appearing in a pemphigus patient treated by corticosteroids, is described and the literature is reviewed.
Lampren bei Vitiligo
Authors: Schuppli R.
Published: October 2009

Lamprene® was given to 20 patients suffering from vitiligo and led only to a partial repigmentation. The cosmetic result did not satisfy the patients. In 1 case, a morbus Dubreuilh-like lesion was stimulated by the lamprene medication.
Penicillamine-Induced Lupus-Like Reaction in Rheumatoid Arthritis and Vasculitis
Authors: Thorvaldsen Johannes
Published: October 2009

A 44-year-old woman with rheumatoid arthritis and vasculitis of the skin developed a lupus erythematosus-like reaction after 5 weeks of D-penicillamine therapy. The diagnosis was established on the clinical and histological picture, immunofluorescence studies and serological investigations. The reaction faded upon cessation of the drug.
Syringomes éruptifs généralisés, grains de milium et atrophodermie vermiculée
Authors: Dupré A. , Carrère S. , Bonafé J.L. , Christol B. , Lassère J. , Touron P.
Published: October 2009

It appears justified to isolate under the term syndrome of Nicolau and Balus’, a group of deformities that include eruptive syringomas of the disseminated micropapular type, milium cysts and atrophoderma vermiculata. We present here a highly typical observation of an 11-year-old child whose mother also presented with eruptive syringomas. This syndrome accentuates the semiological value of disseminated syringomas and atrophoderma vermiculata, which often occur in the context of a complex syndrome. In addition, an associated elastopathy was discovered by light- and electron-microscopic observations.
Hyperkeratosis lenticularis perstans (Flegel)
Authors: van de Staak W.J.B.M. , Bergers A.M.G. , Bongaarts P.
Published: October 2009

2 patients with typical clinical and histological pictures of hyperkeratosis lenticularis perstans were described. Both patients showed abnormalities of the mucosal surface. The ultrastructural findings, both in the cutaneous and in the mucosal lesions, provide strong evidence that the mucosal abnormalities are a real component of hyperkeratosis lenticularis perstans.
Acanthosis nigricans Associated with Adenocarcinoma of the Thyroid Gland
Authors: Verdich Jesper
Published: October 2009

The association between acanthosis nigricans (malignant type) and internal malignant tumour is well established. In the majority of cases the malignant tumour is localized to the gastrointestinal tract or the thoracic cavity. The malignant tumour is believed to be an adenocarcinoma in most cases. A case of malignant acanthosis nigricans associated with a follicular adenocarcinoma of the thyroid gland in a 31-year-old white male with congenital hypothyroidism and eruptive xanthomas due to hyperlipoproteinemia of type V (Frederickson) is reported.
Polyploidization and Hemiploidization Induced by PUVA in vivo
Authors: Omar A. , Wiesmann U.N. , Krebs A.
Published: October 2009

To obtain additional information on the in vivo injury induced by PUVA treatment, primary cultures were initiated from biopsies of the uninvolved skin of 15 PUVA-treated psoriatic patients, and the cells generated were analysed for morphological and chromosomal modifications. Three biopsies were obtained from each patient, the first one before commencing PUVA therapy (control) and the other two during the course of therapy. It was found that PUVA treatment has diverse effects on the mitotic activity, mitotic mechanisms and chromosomes of the cutaneous cells: (1) an inhibition of cell proliferation during the early stages of therapy followed by a reversion to normal proliferation as the PUVA treatments were continued; the production of (2) cells with more than one nucleus, (3) macrocells, (4) cells with micronuclei, (5) polyploid cells, (6) haploid cells, (7) cells with 13 chromosomes denoting a twofold reduction in the normal number of metaphase chromosomes, (8) end-associations of the chromosomes as in the pachytene phase of meiosis (9) diplotene chromosomes, and (10) chromosomal translocations.
Neutrophil Functions in Acne conglobata
Authors: Rebora Alfredo , Dailegri Franco , Patrone Franco
Published: October 2009

Chemotaxis, random migration, phagocytosis, spontaneous and stimulated NBT reduction were evaluated in neutrophüs from the peripheral blood of 8 patients with acne conglobata and were found to be normal. Only 2 patients had an increased spontaneous NBT reduction, and another exhibited a defect in neutrophil adhesiveness. On this basis, intrinsic defects of the major neutrophil functions, as evaluated in vitro, can be excluded in acne conglobata.
Direct Immunofluorescence Studies in Granuloma annulare, Necrobiosis lipoidica and Granulomatosis disciformis Miescher
Authors: Nieboer C. , Kalsbeek G.L.
Published: October 2009

Direct immunofluorescence studies in granuloma annulare, necrobiosis lipoidica and granulomatosis disciformis Miescher are reported. In all 29 cases fibrillar deposits of fibrin in the necrobiotic areas have been found. Complement, mainly C3, was present in the region of the dermo-epidermal junction in 83% of the cases. Although the walls of the vessels in the superficial layers of the dermis showed a positive staining with antifibrinogen and complement, those around the necrobiotic areas were negative in most of the cases. The possible significance of these findings for the pathogenesis has been discussed.
Diffuse Biphasic Cutaneous Amyloidosis
Authors: Bedi T.R. , Datta B.N.
Published: October 2009

2 patients with primary localized cutaneous amyloidosis were seen to have widespread macular and lichenoid types of lesions. Diffuse areas of pigmentation appeared to transform gradually over years into lichen amyloidosus as a result of chronic irritation of the skin from scratching. There was no evidence of systemic amyloidosis.
Morphaea-like Cutaneous Changes in a Patient with Systemic Scleroderma
Authors: Ikai Kouichi , Tagami Hachiro , Imamura Sadao , Hayakawa Minoru
Published: October 2009

A case of systemic scleroderma with peculiar morphaea-like lesions is reported. The patient at first started with typical acrosclerosis, some parts of which later became softened and apparently resumed the appearance of normal skin, so that morphaea-like cutaneous plaques which remained hard, were soft. These changes were surrounded by erythema resembling the ‘lilac ring’ as noted in characteristic active lesions of morphaea.
Low-Dose Chlorambucil in the Treatment of Generalized Granuloma annulare
Authors: Kossard Steven , Winkelmann R.K.
Published: October 2009

5 of 6 adults with generalized granuloma annulare responded favorably to therapy with low-dose chlorambucil. 5 of the patients had lesions that were recurrent and long-standing and that resisted conventional modalities of therapy. Low-dose chlorambucil may be effective in a short-term therapy program but should be used only in patients with persistent, widespread, or unusual forms of generalized granuloma annulare. The program requires close patient and hematologic supervision.
Skin Petechiae and Ecchymoses (Vasculitis) Due to Anticoagulant Therapy
Authors: Stavorovsky M. , Lichtenstein D. , Nissim F.
Published: October 2009

The appearance of petechiae and ecchymoses following anticoagulant and fibrinolytic therapy is an unusual and rare complication. The mechanism of the vasculitis is obscure but may be related to a chemical vasotoxic reaction. During anticoagulant and fibrinolytic therapy, 6 patients developed petechiae and ecchymoses which was accompanied by pain and fever. There were no disturbances of blood clotting factors. In spite of the varied action of the different anticoagulants and fibrinolytic drugs, the clinical course and the histological examination demonstrated a similar identical vasculitis.
PUVA Treatment in Mycosis Fungoides
Authors: Niemi K.-M.
Published: October 2009

2 patients with mycosis fungoides at the plaque stage were treated with oral methoxalen and UVA irradiation. 3 months later both developed the skin tumours with highly malignant histological picture. In 1 patient at the tumour stage the skin tumours were spreading during the PUVA treatment. 3 patients at the first or eczematoid stage cleared completely or partially by PUVA treatment.
Familial Aquagenic Urticaria
Authors: Bonnetblanc J.M. , Andrieu-Pfahl F. , Meraud J.P. , Roux J.
Published: October 2009

2 cases with the same eruption due to water are reported. This occurs in the same family. 1 case presents a positive patch test with water, and responds well to antihistamines.
Beitrag zur diflusen kutanen Mastozytose im Kindesalter
Authors: Grussendorf Elke-Ingrid , Bär Thomas , Behrendt Heidrun , Redemann Maria
Published: October 2009

We report the case of a 15-month-old child suffering from diffuse cutaneous mastocytosis characterized by blisters and widespread skin involvement but without systemic manifestations. Skin biopsies were examined by electron microscopy. We observed various alterations in the morphology of mast cells and mast cell granules.
Effectiveness of Topically Applied Antibiotics on Anaerobic Bacteria in the Pilo-Sebaceous Duct
Authors: Gloor M. , Kraft H. , Franke M.
Published: October 2009

An unspecific cream vehicle containing 1% erythromycin base was applied once a day for 10 days to one side of the forehead of 16 healthy subjects and the same vehicle without the active agent to the other side. Using the same procedure a solution containing 1.19% clindamycin phosphate (corresponding to 1% clindamycin base) and the corresponding unspecific vehicle was administrated to another group of 17 healthy males. Prior to the treatment and after the end bacteria were obtained from the pilosebaceous ducts by means of a special sampling technique. Both ointments containing the antibiotics lead to a significant reduction of the bacterial growth in the pilosebaceous ducts regardless of whether evaluation is made of the total bacterial count or of Propionibacteria. Thus, it could be demonstrated that topical application enables some antibiotics to penetrate into the pilosebaceous duct in an adequate concentration to ensure antibacterial effectiveness if a suitable vehicle is used.
Schizophrenia and Albinism
Authors: Leibowitz M.R. , Dogliotti M. , Hart G.
Published: October 2009

A female albino with squamous cell carcinoma and schizophrenia is reported. The association of schizophrenia and albinism is exceptionally rare; the observation that schizophrenia is characterised by hypermelanosis is questioned.
Skin Manifestations in Acute Lymphatic Leukosis
Authors: Arnerić S. , Karadaglić Dj. , Krstić C.
Published: October 2009

A very rare case of acute lymphatic leukosis with skin changes preceding the complete clinical manifestation has been described.
Study of the Effects of Certain Drugs on Experimental Porphyria in Rats
Authors: Deshpande S.G. , Kandhari K.C. , Narang B.S. , Bikhchandani R. , Bhutani L.K.
Published: October 2009

The effect of ethanol, phenobarbitone, griseofulvin or chloroquine on 3,4-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced porphyria in rats has been studied in experiments lasting up to 40 days. Ethanol, phenobarbitone or griseofulvin given later, in addition to DDC, resulted in a clearly greater porphyrin excretion and liver porphyrin concentration than with DDC alone. Chloroquine at first increased, then decreased porphyrin excretion and liver porphyrin was lowered. No drug without DDC was porphyrogenic.
Inflammatory Linear Verrucose Epidermal Naevus or Linear Psoriasis
Authors: Geerts M.L. , Kint A. , de Vleeschouwer L.
Published: October 2009

Description of a case of inflammatory linear verrucose epidermal naevus in a family with psoriasis. The initial lesion is histologically a spongiform pustule. Although the diagnosis of inflammatory linear verrucose epidermal naevus can be made on the entire histological image, the distinction from psoriasis can be difficult.
Papillon-Lefèvre Syndrome: Report of Two Familial Cases
Authors: Bravo-Piris J. , Villaron L.G. , Martinez C. , Garcia-Perez A.
Published: October 2009

Two cases with Papillon-Lefèvre Syndrome (PLS) are reported. They are two brothers belonging to a family in which there is strong consanguinity. An autosomal recessive pattern of inheritance is suggested. Some pathological findings as congenital bronchiectasis observed in one of the patients as well as the PLS features are discussed and considered to be fortuitous defects. These observations are compared with those described in the literature.
Bullous Fixed Drug Eruption Presumably Due to Erythromycin
Authors: Naik R.P.C. , Singh Gurmohan
Published: October 2009

A case of bullous fixed drug eruption involving upper lip, tongue and foot, presumably due to erythromycin, is reported. It is perhaps the first report of erythromycin to be very likely the cause of fixed drug eruption.
A Study of the Immunological Status of Patients with Dermatophytoses
Authors: Abraham S. , Pandhi R.K. , Kumar R. , Mohapatra L.N. , Bhutani L.K.
Published: October 2009

22 patients with Trichophyton rubrum infection were studied for some of their immunological parameters. The trichophytin skin test performed with commercially available Dermatophytin (Hollister-Stier) gave immediate positive reaction in 3 patients. All the other patients gave negative delayed and retarded reactions. In vitro response to PHA of the peripheral lymphocytes was significantly depressed in patients as compared to the controls. No relationship could, however, be established between the severity, duration or extent of the disease and the depression of the lymphocyte response. IgG and IgA were found to be within normal limits. IgM levels were significantly depressed which was probably artefactual in nature.
Solitary Papular Lesions on the Penis in Insufficiently Treated early Syphilis
Authors: Notowicz A. , Menke H.E. , Stolz E. , Vuzevski V.D.
Published: October 2009

Two cases of insufficiently treated early syphilis with solitary papular lesions on the penis are described. There seems to be a close resemblance between these cases and descriptions from the Salvarsan era concerning the occurrence of solitary papules located on or near the place of the healed primary syphilitic lesion, after insufficient treatment with Salvarsan. Problems in diagnosing these cases are discussed.
Pseudoxanthoma elasticum and Elastosis perforans serpiginosa
Authors: Caro I. , Sher M.A. , Rippey J.J.
Published: October 2009

Two cases of pseudoxanthoma elasticum with elastosis perforans serpiginosa are presented. The two conditions and their association are briefly discussed.
Mitteilungen – Communications Statistique des tests épicutanés positifs de 1000 cas d’eczéma de contact
Authors: Brun Robert
Published: October 2009

Results concerning 1,000 cases of contact dermatitis with positive patch-tests are published and commented. The allergens which are responsible for about 50% of our cases are: turpentine, nickel, hexavalent chromium and mercuri-organic compounds. These results are compared with those of other countries. As in the industrial world there should be information given to the general public to decrease the cases of contact dermatitis.
Cutaneous Involvement in Erythroleukemia
Authors: Shaklai M. , Nir M. , Feuerman E. , Pinkhas J. , de Vries A.d.
Published: October 2009

A rapidly necrotizing leukemic skin infiltrate appeared simultaneously with a fatal blastic crisis in a patient with chronic erythroleukemia. Local X-ray irradiation and systemic cytotoxic, antibiotic and corticosteroid treatment were of no avail.
Fibrinolysis and Thrombosis in Behçet’s Disease
Authors: Sobel J.D. , Tabori S. , Tatarski I.
Published: October 2009

Venous thrombosis, including superior and inferiorvena caval occlusion is considered an integral manifestation of Behçet’s disease. In this series, 5 of 11 patients (45.4%) with active Behçet’s disease had clinical evidence of present or past venous thrombosis. The mean euglobulin lysis time in the 11 subjects was found to be within the normal range: however, in 3 patients, significant impairment of fibrinolytic activity was demonstrated. Inhibition of systemic fibrinolysis may be a contributory factor in the pathogenesis of the thrombotic diathesis characteristic of Behçet’s disease.
Follicular Keratoses
Authors: Günther S. , Alston W.
Published: October 2009

The normal ranges of vitamin A (retinol) and carotene were investigated in 31 healthy subjects. In 3 patients suffering from hyperkeratosis follicularis et parafollicularis (Kyrle’s disease), pityriasis rubra pilaris, and keratosis follicularis (Darier’s disease), the serum level of vitamin A was found to be either beneath or in the lower part of the normal range. Striking improvement has been noted when these patients were treated systemically with retinoic acid (vitamin A acid) which was associated with elevation of serum levels of vitamin A and carotene. All the laboratory tests remained within normal limits. Several possibilities regarding the aetiology and treatment of these skin conditions are discussed.
Epidermolysis bullosa dystrophica dominans – ein Defekt der anchoring fibrils
Authors: Anton-Lamprecht Ingrun , Schnyder Urs.W.
Published: October 2009

Ultrastructural studies on a familiar case of Epidermolysis bullosa dystrophica dominans have demonstrated that normal anchoring fibrils are missing in the junctional area beneath the basal lamina; some rudimentary fibrils without typical banding patterns may be found occasionally. All other junctional structures, i.e. half desmosomes, plasmamembrane, anchoring filaments, and basal lamina, are of normal ultra-structure. The bulla is formed subepidermally, the basal lamina remaining at the top of the bulla.
La variété médio-dorsale de l’infiltration lymphocytaire de la peau (Jessner et Kanof)
Authors: Dupré A. , Bolinelli R. , Christol B. , Bonafé J.L.
Published: October 2009

A very peculiar type of skin lymphocytic infiltration is the elective mediodorsal localization: two characteristic cases are described, one of them associated with lung Hodgkin’s disease. On the basis of these two cases, the authors regard the lymphocytic infiltrate as an entity definitely distinct from chronic lupus erythematosus, but probably related to benign lymphocytic reticulosis.