bluuebunny/crossref_metadata_2025 huggingface dataset:
relação entre catalogação e o serviço de referência
Authors: Arias Luiza , Silveira Naira Christofoletti
Published: January 2021

Este artigo possui como temática a relação entre o serviço de referência e a catalogação, no que diz respeito a importância da conexão do trabalho do bibliotecário catalogador com o trabalho do bibliotecário de referência para o atendimento eficiente das necessidades do usuário. Tem como objetivo revelar a relação entre o serviço de referência e o catálogo, através das tarefas do usuário dos Requisitos Funcionais para Registros Bibliográficos (FRBR) e das seis fases do processo de referência propostas por Nice Figueiredo. Trata-se de uma pesquisa bibliográfica e documental. Para a elaboração deste trabalho foi realizada uma revisão de literatura referente aos assuntos tratados no mesmo: o catálogo, as tarefas do usuário do FRBR e o serviço de referência. Observou-se que os dois campos de estudo se relacionam na literatura e ambos são necessários para um atendimento de qualidade ao usuário.
Cachaça e escravidão em Ilhéus
Authors: Andrade Marcelo Loyola de
Published: January 2021

Esse artigo analisa o trabalho escravo e a produção de aguardente de cana em Ilhéus, sul da Bahia, entre 1850 e 1888. Nesse período a economia da localidade se desenvolveu com a expansão dos engenhos de açúcar e o cultivo do cacau, entre outras atividades econômicas. Nossa proposta é investigar a cachaça e a escravidão nesse contexto, as fontes principais são inventários post mortem, Livros de cobrança de impostos, Livro de classificação dos escravos, Recenseamento do Brasil (1872) e relatos de viajantes estrangeiros. Os objetivos consistem em analisar o mundo do trabalho dos escravizados envolvidos na produção da bebida, as exportações e os exportadores do destilado e a importância econômica e social do produto.
Especialistas y expertos del saber corporal
Authors: Scharagrodsky Pablo Ariel
Published: January 2021

el siguiente trabajo analiza la Primera Conferencia de Profesores de Educación Física realizada en la ciudad de Buenos Aires en 1942. A partir de la historia social y cultural, pensamos al evento -el primero en su tipo en la Argentina- como un lugar que permite identificar narrativas en común, lógicas de sentido dominantes, discontinuidades temáticas y puntos de discordia sobre la educación del movimiento. Asimismo, exploramos el evento como una caja de resonancia que visibiliza tensiones, acuerdos y conflictos entre personas, organizaciones y grupos de especialistas o expertos. Nuestra hipótesis sugiere que el evento con continuidades y rupturas de sentidos en los discursos, saberes y prácticas de la educación física, legitimó a ciertos actores, grupos ocupacionales, propuestas e instituciones por encima de otras.
Tasa de interés neutral y política monetaria para México, 2020-2024
Authors: Sánchez Vargas Armando , Martínez Ventura Débora , López-Herrera Francisco
Published: January 2021

Debido a la incertidumbre al respecto, en este artículo se analiza cuál podría ser la postura de política monetaria más adecuada para México: una que mantenga el objetivo de inflación sin afectar negativamente el crecimiento del producto. Se estima el valor de la tasa de interés neutral en México para los próximos cinco años con base en la regla de Taylor y un modelo vectorial autorregresivo (VAR) cointegrado (CVAR). Los resultados sugieren que la tasa de política monetaria se encuentra por arriba de la tasa neutral de interés, lo que, combinado con el potencial recorte de tasas a escala internacional, podría conceder al banco central durante casi todo el sexenio grados de libertad para mantener su tasa por debajo del nivel actual; en el corto plazo se podría recortar la tasa de política monetaria actual en 25 puntos al menos sin arriesgar la convergencia a la meta de inflación.
Cambio en la estructura productiva, 1995-2011: China versus México
Authors: Núñez Rodríguez Gaspar
Published: January 2021

Este trabajo realiza un análisis comparativo de la estructura productiva de las economías de China y de México mediante un estudio descriptivo y los métodos del análisis estructural aplicados a matrices de insumo-producto para 1995 y 2011. Durante este periodo el crecimiento del producto interno bruto (PIB) per cápita en China alcanzó un promedio de 9.18% anual, mientras que para México fue de sólo 0.95%. Si asumimos que el crecimiento de China ha sido exitoso en este sentido, entonces, la principal conclusión de este trabajo es que, en caso de que México desee alcanzar tasas de crecimiento altas, el principal elemento potencialmente aprovechable desde la experiencia de China para elaborar una estrategia eficaz está claro: impulsar, desde una participación proactiva del Estado, el desarrollo de sectores clave que incrementen constantemente sus efectos multiplicadores con el fin de lograr la mayor integración posible del aparato productivo nacional, y, por lo tanto, el desarrollo y la consolidación de una planta productiva suficiente, sobre la que luego se cimente la gestión de sectores productivos de nueva generación.
¿A qué se llama y con qué fin se critica al capitalismo?
Authors: Altvater Elmar
Published: January 2021

Con base en una célebre frase del filósofo Friedrich Schiller respecto de la historia universal, Elmar Altvater se pregunta de manera homónima sobre el capitalismo y reflexiona sobre la importancia de criticarlo. Analiza las transformaciones de este sistema económico desde que se originó en el siglo XVIII y aborda críticamente su funcionamiento actual, así como las consecuencias que ha tenido, en particular su falta de sostenibilidad en un mediano plazo. Plantea la vital importancia de que este sistema no únicamente se estudie desde la economía, sino desde una perspectiva multidisciplinaria que incluya otras ciencias sociales, como la política y la sociología, además de las ciencias naturales, con el fin de abarcar al capitalismo desde todos sus ángulos y abrir espacio para nuevas ideas.
Relación entre inteligencia emocional y riesgo de adicción a redes sociales en estudiantes de educación superior no universitaria de Lima Metropolitana
Authors: Rivera-Véliz Alejandra Jóse , Araujo-Robles Elizabeth Dany
Published: January 2021

El objetivo fue identificar la relación entre la inteligencia emocional y el riesgo de adicción a las redes sociales en un grupo de estudiantes de un instituto de educación superior no universitaria de Lima. El estudio se realizó en 150 estudiantes de entre 16 y 27 años. Se utilizaron el Trait Meta-Mood Scale 24 y el Cuestionario de Adicción a Redes Sociales (ARS). La correlación entre las puntuaciones globales fue baja y no significativa (r =-,04; p=,625), pero se hallaron correlaciones negativas entre claridad emocional y reparación emocional con indicadores de obsesión por las redes sociales. En cambio, la atención emocional correlacionó positivamente con indicadores de falta de control y uso excesivo de las redes sociales. Estos resultados apuntan a la conclusión de que la claridad emocional y la reparación emocional son componentes fundamentales de la inteligencia emocional, definida como habilidad, en tanto que la atención emocional está relacionada no propiamente con la habilidad de auto-monitoreo emocional, sino más bien con la tendencia a realizar este auto-monitoreo, en particular en individuos con malestar emocional.
Valoración de las competencias digitales en docentes universitarios
Authors: Pozú-Franco Jamine , Fernández-Otoya Fiorela Anaí , Muñoz-Guevara Liliana
Published: January 2021

El objetivo fue determinar el valor de las competencias digitales en 32 profesionales que ejercen docencia en una universidad privada de Lima. La metodología utilizada fue descriptiva y de carácter cuantitativo. Los datos fueron obtenidos mediante el Cuestionario Competencias Digitales, el cual se estructuró en cinco factores: alfabetización tecnológica, acceso y uso de la información, comunicación y colaboración, ciudadanía digital y creatividad e innovación. Los resultados revelaron que más de la mitad de los docentes valoraron como importantes o muy importantes todas las competencias evaluadas. Además 28 de las 43 competencias evaluadas fueron consideradas como muy importantes por la mitad o más de los docentes. Se concluye que la educación superior enfrenta como uno de sus más importantes desafíos la incorporación de los recursos tecnológicos al proceso E-A y la preparación de los docentes en el uso de dichos recursos.
Personal Branding Pustakawan di Dinas Perpustakaan dan Kearsipan Provinsi Bengkulu
Authors: Saputra Jenni Noka , Darubekti Nurhayati , Sa’diyah Lailatus
Published: January 2021

Penelitian ini bertujuan untuk mengetahui bagaimana bentuk personal branding pustakawan di Dinas Perpustakaan dan Kearsipan Provinsi Bengkulu dalam upaya untuk membentuk citra yang positif terhadap profesi pustakawan dan perpustakaan dan juga berupaya untuk meningkatkan kunjungan pemustaka ke perpustakaan melalui personal branding yang dilakukan oleh pustakawan tersebut. Penelitian ini menggunakan metode deskriptif kualitatif dengan rancangan bersifat kualitatif yang diperoleh dengan wawancara dan observasi terhadap informan. Metode purposive sampling digunakan untuk memperoleh informan dalam penelitian ini dengan mengambillima informan yang sesuai dengan pertimbangan tersebut. Periode penjaringan data pada penelitian ini dimulai dari bulan Maret sampai Juni 2020. Peneliti menggunakan teori pedoman pembentukan personal branding oleh Peter Montoya yang terdapat delapan aspek kemudian membandingkan dengan personal branding yang ditampilkan oleh informan yang didapat melalui observasi dan wawancara. Hasil penelitian menunjukan dari kelima informan hanya satu informan yang menerapkan delapan aspek pembentukan personal branding dari Peter Montoya.
Digital Literacy Skill dalam Upaya Peningkatan Laba Usaha pada Kalangan Pelaku Usaha Kecil di Kota Surabaya
Authors: Zahro Eka Khusniatuz
Published: January 2021

Pelaku usaha di tuntut untuk memiliki kemampuan menerima sebuah informasi dan juga diimbangi dengan kemampuan untuk menelusur dan mengidentifikasi informasi yang diterima terutama dalam bentuk digital atau yang disebut dengan kemampuan literasi digital. Kota Surabaya menjadi salah satu kota yang berpotensi menghasilkan sebuah produk atau usaha untuk membantu perekonomian masyarakat. Terbukti dengan Usaha Mikro Kecil Menengah (UMKM) di Kota Surabaya saat ini mendapat perhatian khusus oleh Dinas Koperasi Usaha Kecil dan Menengah dimana Kota Surabaya menjadi salah satu wilayah dengan jumlah UMKM yang tinggi yaitu mencapai 260 ribu lebih pelaku Usaha Mikro Kecil dan Menengah (UMKM). Kondisi kemampuan pelaku usaha skala kecil di Kota Surabaya dalam menggunakan media digital pada sebagian pelaku usaha di Kota Surabaya saat ini lebih condong di kelompokkan ke dalam kelompok early majority dan masih melakukan pemasaran usaha dalam bentuk offline. Melihat kondisi tersebut, maka di perlukan kemampuan literasi digital bagi setiap individu sebagai pelaku usaha agar dapat dengan mudah dalam mencari, menemukan, memanfaatkan dan menggunakan teknologi informasi. Penelitian menggunakan jenis penelitian kuantitaif deskriptif dan metode pengumpulan sampel yang digunakan ialah purposive sampling dengan jumlah responden sebanyak 104. Hasil dari penelitian ini menunjukkan kemampuan literasi digital pada pelaku usaha skala kecil di Kota Surabaya dalam kategori sangat tinggi. Terdapat dampak positif kemampuan pemasaran online terhadap omset penjualan dalam satu bulan dan dampak positif intensitas mengikuti forum di media sosial dengan laba bersih dalam satu tahun.
The Failure of New International Economic Order: a Lesson Learned
Authors: Aiyub Kadir M. Ya'kub
Published: January 2021

The establishment of the New International Economic Order (NIEO) has been underpinning the development of international law. The shortcomings of this struggle should be seen as a lesson-learn to step forward in the future. It is also essential to harmonise the economic justice relationship among all countries in the world regardless the developed or the developing countries. The sustainable struggle in the world economic sphere will appear as a shout from the perceived disadvantaged countries from an economic competition in the world.  The establishment of the right to development that have been adopted in international law is a part of journey of TW struggled in international relation. The paper is simultaneously based on the perception of understanding of principles of  NIEO coupled with scepticisms toward this principles and auto criticism of that scepticism in order to be a proposal as a source of international law in future
Dynamics of Reasonableness and Fairness in a Pluralistic Legal System: Perspectives from Adat, Islamic and Civil Inheritance Law
Authors: Putri Annida Aqiila , Jansen Bart
Published: January 2021

Reasonableness and fairness are keystones of law. They are implemented broadly and important doctrine for civil law. However, the open nature of reasonableness and fairness allow various interpretations, influenced by the legal system, legal tradition, jurisprudence or measured on a case per case basis. Indonesia recognizes more than one kind of a legal system, making it a legal pluralist State. This article aims to describe the dynamics of the reasonableness and fairness principle within a pluralistic legal system. Indonesian inheritance laws use three different legal systems: Adat, Islam, and civil law, each provides distinctive perspectives of reasonableness and fairness. These differences may lead to a clash of interpretation or it may leave a wide room of discretion for the judges. Court judgments are analyzed to examine the implementation of such dynamics in practice. Finally, the outcome of the paper concludes whether the differences shall be embraced or whether there is a need to agree upon what is ‘reasonable’ and ‘fair’.
Regional Head Election During COVID-19 Pandemic: the Antinomy in the Government Policies
Authors: Ramadani Rizki , Rezah Farah Syah
Published: January 2021

Welcoming the simultaneous regional head election in 2020, it is expected to be an entry point in building a higher quality democracy in Indonesia. Initially, this year's election should be held on September 23. However, this plan must be constrained when the coronavirus disease 2019 (COVID-19) outbreak occurs and spread wildly all over the world including Indonesia, and was officially declared a pandemic by World Health Organization (WHO). When the number of positive cases and deaths continues to increase, the government decided to continue holding the regional election in the midst of the pandemic. Such policy created controversy and faced several challenges, especially regarding the government's inconsistency in fulfilling the rights of its people in the time of the pandemic. This article aims to explain and analyze the contradiction in the government policies from the antinomy of law and human rights perspective. This legal research is doctrinal research conducted using a conceptual, statutory, and case approach. The data will be described in a descriptive-prescriptive manner through qualitative analysis. The results of the analysis show that there are some contradictions between policies regarding physical distancing (both in the Large-Scale Social Restrictions (PSBB) and Health Protocol regulations) and the policy for holding Regional Head Elections during the pandemic. In essence, this contradiction is the antinomy between the aspects of public health and political rights. Antinomies occur when the government seeks to fulfill and guarantee political rights as well as public rights to health at the same time during a pandemic, which actually leads to mutual negation between these rights.
Contextual Emotion Appraisal Based on a Sentential Cognitive System for Robots
Authors: Ahn Hyunsik , Park Sung
Published: January 2021

Emotion plays a powerful role in humans’ interaction with robots. In order to express more human-friendly emotions, robots need the capability of contextual appraisal that expresses the emotional relevance of various targets in the spatiotemporal situation. In this paper, an emotional appraisal methodology is proposed in this study to cope with such contexts. Specifically, the Ortony, Clore, and Collins model is abstracted and simplified to approximate an emotional appraisal model in the form of a sentence-based cognitive system. The contextual emotion appraisal is modeled by formulating the emotional relationships among multiple targets and the emotional transition with events and time passing. To verify the proposed robotic system’s feasibility, simulations were conducted for scenarios where it emotional interacts with humans manipulating liked or disliked objects on a table. This experiment demonstrated that the robot's emotion can variously change over time like human by using a proposed formula for emotional valence, which is moderated by emotion appraisal of occurring events.
Emergence of Objective Reality in an Irreversible Friend thought Experiment
Authors: Shuler Robert
Published: January 2021

Background: Recently some photon models of a Wigner's friend experiment have led investigators to suggest objective reality does not exist, and to publish non-academic articles with such claims. The public is not equipped to evaluate the severe limitations of these experiments. The separation of Wigner from the experiment and use of only reversible coherent processes for the friend allow operations that are not possible in ordinary reality according to the latest quantum research. Methods: We suggest directly testing the implied claim that objective reality, including incoherent objects with irreversible non-destructive memory, can be held in superposition. We suspect it will fail, but provide for a graduated approach that may discover something about the conditions for superposition collapse. To this end we design a thought experiment to model the objective world, investigating under what conditions experimenters in the same world (ensemble member) will be able to record a result and find it does not appear to change. An observer has a viewing apparatus and a memory apparatus. A second uncorrelated viewer of the same recorded result is employed to obtain objectivity. By hypothesis the uncorrelated second viewer obtains the same view of the measurement record as the first observer. There are not two measurements. This is not an investigation of hidden variables. Results: To model the objective world, incoherent and irreversible processes must be included. To test for superposition, coherence has to be established. These seem to present a contradiction. Conclusions: The thought experiment has suggested new places to look other than size for the origin of objective reality from the quantum world, casts doubt on the Many-Worlds interpretation, and provides a method of testing it.
Mesh-type 3D Printing of Human Organs and Tumors: Fast, Cost-Effective, and Personalized Anatomic Modeling
Authors: Seok Jungirl , Yoon Sungmin , Ryu Chang Hwan , Ryu Junsun , Kim Seok-ki , Jung Yuh-Seog
Published: January 2021

OBJECTIVE: Although 3D-printed anatomic models are not new to medicine, the high costs and lengthy production times entailed have limited their application. Our goal was developing a new and less costly 3D modeling method to depict organ-tumor relations at faster printing speeds. METHODS: We have devised a method of 3D modeling using DICOM images. Coordinates are extracted at a specified interval, connecting them to create mesh-work replicas. Adjacent constructs are depicted by density variations, showing anatomic targets (ie, tumors) in contrasting color. RESULTS: An array of organ solid-tumor models were printed via Fused Deposition Modeling 3D printer at significantly less cost ($0.05/cm3) and time expenditure (1.73 min/cm3; both, p<.001). Printed models helped promote visual appreciation of organ-tumor anatomy and adjacent tissues. Our mesh-work 3D thyroidal prototype reproduced glangular size/contour and tumor location, readily approximating the surgical specimen. CONCLUSIONS: This newly devised mesh-type 3D printing method may facilitate anatomic modeling for personalized care and improve patient awareness during informed surgical consent.
In Schizophrenia, Depression and Anxiety Symptoms Are Driven by Immune-Inflammatory Pathways.
Authors: Almulla Abbas , Al-Rawi Khalid , Maes Michael , Kadhem Al-Hakeim Hussein
Published: January 2021

Background. The aim of this study is to examine whether biomarkers of the immune-inflammatory response (IRS) and endogenous opioid (EOS) systems are associated with affective symptoms in schizophrenia. Methods. We recruited 115 schizophrenia patients and 43 healthy controls and assessed the Hamilton Depression (HDRS) and Anxiety (HAM-A) rating Scale scores as well as serum levels of interleukin (IL)-6, IL-10, eotaxin (CCL11), high mobility group box 1 (HMGB1), Dickkopf-related protein 1 (DKK1), and mu (MOR) and kappa (KOR) opioid receptors.Results. The HDRS and HAM-A scores are significantly and positively correlated with a) psychosis, hostility, excitation, mannerism, negative symptoms, psychomotor retardation, and formal thought disorders; and b) lowered scores on semantic and episodic memory, executive functions, and attention tests as measured with the Brief Assessment of Cognition in Psychiatry. Both HDRS and HAM-A are significantly increased in non-responders to treatment as compared with partial responders. Both affective scores are strongly associated with latent vectors extracted from all symptoms, reflecting overall severity of psychosis (OSOS), and neurocognitive test scores, reflecting a generalized cognitive decline (G-CoDe). The HDRS score was strongly and positively associated with IL-6, HMGB1, KOR, and MOR levels, and the HAM-A score with IL-6, IL-10, CCL11, HMGB1, KOR, and MOR levels. A single latent trait may be extracted from OSOS, G-CoDe, and the HDRS and HAMA scores, and this latent vector score is strongly predicted by HMGB1, MOR, and DKK1.Conclusion. Immune-inflammatory and EOS pathways contribute to the phenome of schizophrenia, which comprises OSOS, affective, and physiosomatic symptoms, and G-CoDe.
Interstitial Fluid Flow and Transport in Glioblastoma and Surrounding Parenchyma in Patients
Authors: Chatterjee Krishnashis , Atay Naciye , Abler Daniel , Bhargava Saloni , Sahoo Prativa , Rockne Russell , Munson Jennifer
Published: January 2021

Background: Glioblastoma is the deadliest, yet most common, brain tumor in adults, with poor survival and response to aggressive therapy. Therapeutic failure results from a number of causes inherent to these tumors. Imaging, computational, and drug delivery approaches can aid in the quest to access and kill each tumor cell in patients. One factor, interstitial fluid flow, is a driving force therapeutic delivery. However, convective and diffusive transport mechanisms are un-der-studied. In this study, we examine the application of a novel image analysis method to meas-ure fluid flow and diffusion in glioblastoma patients with MRI and compare to patient outcomes. Methods: Building on a prior imaging methodology tested and validated in vitro, in silico and in preclinical models of disease, here we apply our analysis method to archival patient data from the Ivy GAP dataset. Results: We characterize interstitial fluid flow and diffusion patterns in patients. We find strong correlations between flow rates measured within tumors and in the surrounding parenchymal space, where we hypothesized that velocities would be higher. Looking at overall magnitudes, there is significant correlation with both age and survival in this patient cohort. Additionally, we find that tumor size nor resection significantly alter the velocity magnitude. Last, we map the flow pathways in patient tumors and find variability in degree of directionality that we hypothesize in future studies may lead to information concerning treatment, invasive spread, and progression. Conclusions: Analysis of standard DCE-MRI in patients with glioblastoma offers more infor-mation regarding transport within and around tumor, can be measured post-resection and mag-nitudes correlate with patient prognosis.
The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection
Authors: O'Neil Thomas Ray , Hu Kevin , Truong Naomi , Arshad Sana , Shacklett Barbara , Cunningham Anthony Laurence , Nasr Najla
Published: January 2021

Tissue resident memory T cells (TRM) were first described in 2009. While initially the major focus was on CD8 TRM, there has been recently an increased interest in defining the phenotype and the role of CD4 TRM in diseases. Circulating CD4 T cells seed tissue CD4 TRM, but there also appears to be an equilibrium between CD4 TRM and blood CD4 T cells. CD4 TRM are more mobile than CD8 TRM, usually localized deeper within the dermis/lamina propria and yet may exhibit synergy with CD8 TRM in disease control. This has been demonstrated in herpes simplex infections in mice. In human recurrent herpes infections, both CD4 and CD8 TRM persisting between lesions may control asymptomatic shedding through interferon gamma secretion, although this has been more clearly shown for CD8 T cells. The exact role of the CD4/CD8 TRM axis in the trigeminal ganglia and/or cornea in controlling recurrent herpetic keratitis is unknown. In HIV, CD4 TRM have now been shown to be a major target for productive and latent infection in cervix. In HSV and HIV co-infections, CD4 TRM persisting in the dermis support HIV replication. Further understanding of the role of CD4 TRM and their induction by vaccines may help control sexual transmission by both viruses.
Tackling the Moving Mutant Target: Taxifolin Derivatives as Novel Putative E571K Exportin-1 Inhibitors for KRAS-mutant Lung Adenocarcinoma Therapy
Authors: Adigun Temidayo , Medayedupin Oluwatobi , Joel Ireoluwa , Fakolujo Idowu , Ofeniforo Bankole , Bankole Faith , Omoniyi Adedayo , Ogunro Olalekan , Agunlejika Adebimpe , Omoyeni Oluwatobi , Bamidele Joy , Ajayi Adetola
Published: January 2021

Aim: To establish, through molecular modelling, safe and clinically acceptable putative antagonists of E571K-mutated exportin-1 among the bioactive compounds in various parts of Juglans mandshurica. Methods: The bioactive compounds were subjected to compendium of druglikeness and lead-likeness filter workflows prior to docking of the resultant compounds into E571K exportin-1 active site using PyRx AutoDock vina to establish their binding affinity and interaction profile. The evolutionary algorithm of Osiris property explorer DataWarrior software as well as lead-likeness filter were employed for generation of novel non-promiscuous analogues of the lead compound with better putative selectivity and clinical acceptability as E571K Exportin-1 antagonists.Results: The findings of this study present taxifolin as the putatively effective and lead-like E571K Exportin-1 inhibitor with high potential of qualifying for clinical evaluation but is associated with high promiscuity tendency in high throughput screening. The evolutionary derivation of novel analogues of the compound, however, results in the generation of putatively non-promiscuous, non-toxic, and lead-like E571K Exportin-1 antagonists with high synthetic accessibility and clinical developability for evaluation in the strategy for treatment of drug-resistant KRAS-mutant lung adenocarcinoma condition.
From Barriers to Enablers: The Role of Organizational Learning in Transitioning SMEs into the Circular Economy
Authors: Scipioni Sara , Russ Meir , Niccolini Federico
Published: January 2021

To contribute to small and medium enterprises (SMEs) sustainable transition into the circular economy, the study proposes the activation of organizational learning (OL) processes – denoted here as multi-level knowledge creation, transfer, and retention processes – as a key phase in introducing circular business models (CBMs) at SME and supply chain (SC) level. The research employs a mixed-method approach, using the focus group methodology to identify contextual elements impacting on CBM-related OL processes, and a survey-based evaluation to single out the most frequently used OL processes inside Italian construction SMEs. As main result, a CBM-oriented OL multi-level model offers a fine-grained understanding of contextual elements acting mutually as barriers and drivers for OL processes, as possible OL dynamics among them. The multi-level culture construct – composed of external stakeholders’, SC stakeholders’, and organizational culture – identify the key element to activate CBM-oriented OL processes. Main implications are related to the identification of cultural, structural, regulatory, and process contextual elements across the external, SC, and organizational levels, and their interrelation with applicable intraorganizational and interorganizational learning processes. The proposed model would contribute to an improved implementation of transitioning into the circular economy utilizing sustainable business models in the construction SMEs.
Recycling of Spent Reverse Osmosis Membranes for the Second Use in Clarification of Wet-Process Phosphoric Acid
Authors: Khaless Khaoula , Achiou Brahim , Boulif Rachid , Benhida Rachid
Published: January 2021

Various techniques have been used to “clean-up” industrial phosphoric acid: precipitation, flotation, activated charcoal or clay treatment. To address membrane processes potential in phosphoric acid clarification process, this study explores the advantage of membrane techniques as new route for phosphoric acid clarification in an eco-efficient way through the use of “regenerated spent membrane”. Regeneration of the spent membranes was performed on of 0.15 m2 active area regeneration. These membrane samples were used to study the phosphoric acid clarification at a laboratory scale. They were immersed in an oxidizer for at most seven days. The samples were characterized systematically before immersion in an oxidant media. In this study, the potential to regenerate spent membranes and application of this media to clarify the 29% P2O5 phosphoric acid was demonstrated. This study shows, by tests that the reverse osmosis (RO) membranes achieve an abatement of 70% and 65% for solids and organic materials, respectively. These positive results will pave the way for implementing these membranes phosphoric acid treatment process. Moreover, besides being economically advantageous, the use of the spent membrane is likely an environmentally friendly route (no waste, no organic solvent and effluent to be regenerated later on).
Inhibin-A Augments Plgf and the Sflt-1 / Plgf Ratio in the Prediction of Preeclampsia and / or Fgr near Delivery
Authors: Sharabi-Nov Adi , Premru Sršen Tanja , Kumar Kristina , Fabjan Vodušek Vesna , Fabjan Teja , Tul Nataša , Meiri Hamutal , Nicolaides Kypros. H , Osredkar Jusko
Published: January 2021

Objective: We previously provided evidence to confirm that soluble Fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and their ratio, are useful tools to direct the management of preeclampsia (PE), fetal growth restriction (FGR), and PE+FGR near delivery. In this study we examine the potential additive value of Inhibin-A, a hormone marker of the transforming growth factor family. Methods: We used a cohort of 125 pregnant women enrolled near delivery at clinics of the University Medical Center of Ljubljana, Slovenia. There were 31 cases of PE, 16 of FGR, 42 of PE+FGR, 15 iatrogenic preterm delivery (PTD), and 21 unaffected controls with delivery of a healthy baby at term. Cases delivered before 34 weeks’ gestation included 13 of PE, 12 of FGR, 22 of PE+FGR, and 6 of PTD. We recorded demographic characteristics and medical history and the levels of PlGF, sFlt-1 and Inhibin-A. The predictive accuracy of each biomarker, their ratios, and combinations was estimated from areas under the curve (AUC) of Receiver Operating Characteristics (ROC) curves. We estimated accuracy by the continuous marker model and a cut-off model. Results: Combining Inhibin-A with PlGF or with the sFlt-1 / PlGF ratio showed a 10-20% increase in AUCs and 5-15% increase in the detection rate, at 10% false positive rate, of PE, and a lower, but significant, increase for PE+FGR but not for FGR alone. The use of a cut-off model was adequate, although a bit higher accuracy was obtained from the continuous model. Highest correlation was found for PlGF with all three complications. Conclusion: Inhibin-A improves the accuracy of predicting PE and PE+FGR provided by the angiogenic markers alone, bringing the results to a diagnostic level, thus assisting in directing clinical management. Inhibin-A had no added value for the accuracy of predicting FGR alone.
CFD Modelling and Optimization Procedure of an Adhesive System for a Modular Climbing Robot
Authors: Hernando Miguel , Gómez Virgilio , Brunete Alberto , Gambao Ernesto
Published: January 2021

Adhesion systems are very important in robots for infrastructure inspection (especially in vertical walls). They present the challenge of optimizing the ratio vacuum/power consumption in battery-powered robots. In this paper a CFD (Computer Fluid Dynamics) modelling and optimization process of a robot adhesion system is carried out to determine the best performing configuration in terms of vacuum and power consumption. Analytical and numerical models were developed to predict the behaviour of the system for different configurations. The models were validated, using test rig measurements, by calibrating an arbitrary defined inlet height that simulates the leakage flow. Then, different geometric parameters were varied to determine the best performing configuration based on the vacuum/power consumption ratio value. The model presented in the paper was capable of predicting the behaviour of the system for different configurations, with a margin of error of 15% for the vacuum prediction and a 25% for the motor power calculation. Finally, the model was used to optimize parameters of the system, like the number of blades of the impeller. The adhesion system was conceived for the modular autonomous climbing legged robot ROMERIN.
The Molecular Landscape of Well Differentiated Retroperitoneal Liposarcoma
Authors: Tyler Robert , Dilworth Mark , James Jonathan , Blakeway Daniel , Stockton Joanne , Morton Dion , Taniere Phillipe , Gourevitch David , Desai Anant , Beggs Andrew D
Published: January 2021

Well differentiated liposarcoma (WD-LPS) is a relatively rare tumour, with less than 50 cases occurring per year in the UK. These tumours are both chemotherapy and radiotherapy resistant and present a significant treatment challenge requiring radical surgery. Little is known of the molecular landscape of these tumours and no current targets for molecular therapy exist. We aimed to carry out a comprehensive molecular characterisation of WD-LPS via whole genome sequencing, RNA-sequencing and methylation array analysis. A recurrent mutation within exon1 of FOXD4L3 was observed (chr9:70,918,189A>T; c.322A>T; p. Lys108Ter). Recurrent mutations were also observed in Wnt signalling, immunity, DNA repair and hypoxia-associated genes. Recurrent amplification of HGMA2 was observed, although this was in fact part of a general amplification of the region around this gene. Recurrent gene fusions in HGMA2, SDHA, TSPAN31 and MDM2 were also observed as well as consistent rearrangements between chromosome 6 and chromosome 12. Our study has demonstrated a recurrent mutation within FOXD4L3, which shows evidence of interaction with the PAX pathway to promote tumorigenesis.
Social Support and Emotional Maturity to Reduce Students’ Online Learning Anxiety During the Covid-19 Pandemic
Authors: Matulessy Andik , Saragih Sahat , Nawafil Nawafil , Perdana Hengki , Pandin Moses
Published: January 2021

The COVID-19 pandemic in Indonesia makes a significant impact both physically and psychologically. One month after the President of the Republic of Indonesia announced about the COVID-19 patient cases, the Indonesian Child Protection Commission data during April 2020, depicted that 76.7% of children were not happy to participate in distance learning because 81.8% were only given assignments by the teacher and 73.2% felt they had a heavy task and had a short period of time to complete. This reaction is an indicator of the children’s anxiety about distance learning. The anxiety that occurs in these students is assumed to depend on their social support and emotional maturity. When students get optimal family support and are able to control their emotions in the face of a pandemic, they can reduce anxiety in facing online learning. The subjects of this study were 202 junior high and high school students. The results showed that social support and emotional maturity simultaneously affect anxiety in online learning (Freg = 45.066, p = 0.00 <0.01). These results can be used as a basis for providing psycho-education to increase family support and emotional maturity to reduce anxiety in online learning.
Oscillating Universe with a Quantized Black Hole
Authors: Kulas Sascha
Published: January 2021

In cosmology dark energy and dark matter are included in the CDM model, but they are still completely unknown. On the other hand the trans-Planckian problem leads to unlikely high photon energies for black holes. We introduce a model with quantized black hole matter. This minimizes the trans- Planckian problem extremely and leads to a scalar field in the oscillating universe model. We show that the scalar field has the same characteristics as a vacuum energy field and leads to the same Casimir effect. Shortly after the beginning of the big bounce this field decays locally and leads to the production of dark matter. In this model no inflation theory is needed. We emphasize that this model is mainly a phenomenological approach with the aim of new impetus to the discussion.
Renal Cell Carcinoma Intravascular Spread Into Segmental Branches of the Renal Vein: A Single Institution Case Series
Authors: Mastropasqua Mauro Giuseppe , Mariano Marta , Fusco Federico , Cazzato Gerardo , Ruggiero Valentina , Battaglia Michele , Lucarelli Giuseppe , Ingravallo Giuseppe , Maiorano Eugenio
Published: January 2021

(1) Background: Overall survival of the patients with renal cell carcinoma (RCC) depends mostly on extra-renal extension, documented by the invasion of the pelvicalyceal system, or the perinephric/renal sinus fat or the renal vein/its segmental intraparenchymal branches. Staging may be challenging because of the high inter-observer variability. We have introduced a more accurate procedure to detect the extra-renal extension and, to possibly evaluate the impact of such more laborious approach, we have compared the RCC pathological staging obtained following both standard and modified procedures; (2) Methods: We selected 54 consecutive cases of RCC diagnosed 18 months before and 54 consecutive cases diagnosed 18 months after the introduction of the new method of sampling. Clinico-pathological characteristics have been statistically analyzed; (3) Results: Most of the features analyzed were non statistically significative, except the extra-renal invasion. More precisely, the occurrence of retrograde venous invasion was higher in the cases grossly approached with the more accurate method; (4) Conclusions: Extra-renal extension to intraparenchymal renal vein branches may be underestimated, leading to an inappropriate under-staging. Using more accurate staging procedures, to disclose the occurrence of intra-renal veins tumoral thrombosis, helps to better define the pathological stage, allowing patients to benefit of better fitting treatments.
Serological Testing for COVID-19 in the Fertility Setting: The Lockdown Impact and Subsequent Dynamics Reflected in the Seroprevalence of Sars-Cov-2 Antibodies
Authors: Manolea Corina , capitanescu andrei , pop anca , bors roxana , rugescu ioana , bechir melihan , mehedintu claudia , varlas valentin
Published: January 2021

The COVID-19 pandemic had profound negative effects on millions of couples affected by infertility and in need to resort to assisted reproductive technologies. There is no consensus over the optimal way and moment of screening triage-negative asymptomatic patients and staff. We present SARS-CoV-2 antibodies’ (IgM, IgG) seroprevalence in 516 triage-negative patients and 30 fertility care providers. The sampling for SARS-CoV-2 serological assays took place from the lockdown release throughout the second half of 2020 (17.05 - 01.12.2020). It revealed an increased seroprevalence of antibodies that closely followed the local epidemiology of COVID-19, with the highest rate of seropositivity coincident with the peak of the second wave. From 546 triage-negative individuals whose blood samples were assessed for SARS-CoV-2 antibodies, 6% yielded positive results. The overall seroconversion rate was 2.8% for IgG and 5.1% for IgM. In the group with positive IgM, we observed a negative predictive value for IgM of 98.36% (95% CI: 88.79 – 99.78%), which is clinically meaningful. Serological testing of triage-negative patients up to seven days prior to the actual fertility procedure might avoid the more expensive and not more sensitive molecular testing currently being used for patient screening in most fertility units.
Understanding the Assumptions Underlying Mendelian Randomization
Authors: de Leeuw Christiaan , Savage Jeanne , Bucur Ioan Gabriel , Heskes Tom , Posthuma Danielle
Published: January 2021

With the rapidly increasing availability of large genetic data sets in recent years, Mendelian Randomization (MR) has quickly gained popularity as a novel secondary analysis method. Leveraging genetic variants as instrumental variables, MR can be used to estimate the causal effects of one phenotype on another even when experimental research is not feasible, and therefore has the potential to be highly informative. It is dependent on strong assumptions however, often producing strongly biased results if these are not met. It is therefore imperative that these assumptions are well-understood by researchers aiming to use MR, in order to evaluate their validity in the context of their analyses and data. The aim of this perspective is therefore to further elucidate these assumptions and the role they play in MR, as well as how different kinds of data can be used to further support them.
Burnout, Positivity and Passion in Young Mexican Athletes: Mediating Effect of Social Support
Authors: Martínez-Alvarado Julio Román , Aguiar Palacios Luis Horacio , Chávez-Flores Yolanda Viridiana , Berengüí Rosendo , Asadi-González Ahmed Ali , Magallanes Rodríguez Ana Gabriela
Published: January 2021

The Burnout syndrome is a negative experience for the athlete development and it has been demonstrated that it gets worse when a sport is practiced in an obsessive way. The interventions about a positive vision through the sport could be a protective factor to boost the athlete’s wellbeing. The aim of the present study was to analyze the mediator effect from social support, the relationship between the burnout, positivity and passion in young Mexican athletes. The sample was composed by 452 Mexican athletes, males and females from 12 to 18 years of age (M = 16.29, SD = 1.66). Participants answered the Athlete Burnout Questionnaire, The Scale of the Social Support Perceived by Athletes, the Passion Scale and the Positivity Scale. The results of structural equation modeling showed the model presented a good adjustment (χ2 = 813.507; df = 229; χ2 /df = 3.552; p < 0.01; CFI = 0.93; TLI = 0.91; IFI = 0.93; NFI = 0.91; RMSEA = 0.07). The positivity and harmonious passion presented direct and indirect effects over the burnout, being the perceived social support the mediator variable of the indirect effects. However, the effect of the obsessive passion mediated by the perceived social support did not resulted significant.
Model for Causes Elimination of Staff Resistance to Innovative Change: evidence from Lithuanian Health Care Institutions
Authors: Drejeris Rolandas , Drejeriene Egle
Published: January 2021

Frequent employee resistance to innovation is one of the main barriers of change failure in a health care organization and one of the negative stimuli of employment relationships. Identifying the reasons of resistance is a topical issue for every organization, as the speed of change can affect their competitiveness. Consequently, it is helpful not only to know the causes of potential resistance but also to be ready to control any implicit opposition. The organizational climate and the attitude of the staff play an important role in understanding and accepting innovation. Purpose of the study is to develop a model, which would facilitate the choice of an appropriate strategy necessary to enable the health care organization to eliminate or at least to reduce resistance to often essential innovative changes. The article analyses the root causes of resistance and identifies strategies that help to mitigate or eliminate staff resistance for innovation. Use of suggested model can make easier reducing staff resistance to change processes and thus speed up the implementation of innovations. This methodology can be used to eliminate the reasons for staff resistance to change in health care institutions of different countries, but it was tested in Lithuania and achieved good enough results.
COVID-19 Is Examining the EU and the Member States: The Role of Attitudes and Sociodemographic Factors on Citizens’ Support Towards National Policies
Authors: Martín Juan Carlos , Román Concepción
Published: January 2021

During March and April 2020, the European Union (EU) was the center of the COVID-19 pandemic. Many National Governments imposed severe lockdown policies to mitigate the health crisis. The European Parliament commissioned a survey to analyse the citizens’ attitudes over a number of issues related to the COVID-19 pandemic. 21804 European citizens in 21 EU countries responded the survey between 23 April and 1 May 2020. The paper analyses empirically the individual satisfaction that European citizens have experienced over the measures taken by the respective National Governments to control the COVID-19 pandemic. The analysis is based on a micro-econometric model (ordered probit) that explains the citizens’ satisfaction by a number of attitudes and sociodemographic factors. Our results reveal that Spaniards are the least satisfied citizens in comparison with Danes, Irelanders, Greeks and Croats who are the most satisfied nationals. The years of education and the social class also play a determinant role. We also find that the most important determinant is the political support to the Government, and that those who are more worried by the economy and the protection of individual rights are usually more critic with the measures than those who are more worried by the health consequences.
Reduction of Antibiotic Residue in Milk Through the Use of Cost Effective Ethno-Veterinary Practices (Evp) for Cattle Health Management
Authors: Nair Balakrishnan M N , Natesan Punniamurthy , Kumar Seethakempanahalli Kempanna
Published: January 2021

This study demonstrated that antibiotic residue in milk can be reduced when dairy farmers use Ethno-veterinary Practices (EVP) based on herbal alternatives to prevent and cure common clinical conditions in cattle instead of antibiotics. Of the 220 farmers selected for the study, 140 were trained and motivated to use validated herbal formulations, 80 were kept as control. Milk samples from the selected farmers (except Thirukanurpatti milk society) tested positive for antibiotic residue in the baseline survey. One year after interventions, the milk from 123 (87.86%) farmers out of 140, were without any detectable antibiotic residue, while samples from 11 farmers (7.85%) were low positive for either Beta-lactams or sulphonamides and 6 (4.29%) were positive for Beta lactams and/or sulphonamides. These 17 (11 + 6) farmers had used antibiotics along with herbal formulations. The milk samples from the control groups were positive for beta lactam and sulphonamide. There was suggestive significance of change in knowledge, attitude and practice of EVP among the farmers from Kerala and Tamil Nadu. A progressive reduction in the incidence of mastitis, enteritis, repeat breeding and cowpox were observed from 2016 to 2019 among the cows treated with EVP. Use of herbal alternative also resulted in a significant reduction in health care expenditure of cattle.