bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute respiratory failure due to pulmonary exacerbation in children with cystic fibrosis admitted in a pediatric intensive care unit: outcomes and factors associated with mortality
Authors: Drummond David , Roy Charlotte , Cornet Matthieu , Bucher Julie , Boussaud Véronique , Pimpec-Barthes Françoise Le , Pontailler Margaux , Raisky Olivier , Lopez Vanessa , Barbanti Claudio , Guillemain Romain , Renolleau Sylvain , Grimaud Marion , Oualha Mehdi , Blanquat Laure de Saint , Gaudelus Isabelle Sermet
Published: January 2024

Background.
Children with advanced pulmonary disease due to cystic fibrosis (CF) are at risk of acute respiratory failure due to pulmonary exacerbations leading to their admission to pediatric intensive care units (PICU). The objectives of this study were to determine short and medium-term outcomes of children with CF admitted to PICU for acute respiratory failure due to pulmonary exacerbation and to identify prognosis factors.
Methods.
This retrospective monocentric study included patients less than 18 years old admitted to the PICU of a French university hospital between 2000 and 2020. Cox proportional hazard regression methods were used to determine prognosis factors of mortality or lung transplant.
Results.
Prior to PICU admission, the 29 patients included (median age 13.5 years) had a severe lung disease (median Forced Expiratory Volume in 1 second percentage predicted at 29%). Mortality rates were respectively 17%, 31%, 34%, 41% at discharge and at 3, 12 and 36 months post-discharge. Survival rates free of lung transplant were 34%, 32%, 24% and 17% respectively. Risk factors found associated with mortality or lung transplant using the univariate analysis were female sex and higher pCO2 and chloride levels at PICU admission, and regarding pre admission characteristics: home respiratory and nutritional support, registration on lung transplant list and Stenotrophomonas maltophilia bronchial colonization.
Conclusion.
Children with CF admitted to PICU for acute respiratory failure secondary to pulmonary exacerbations are at high risk of death, both in the short and medium terms. Lung transplant is their main chance of survival and should be considered early.
Stigma and its associations with self-confidence and sexual relations in 4 types of premature ejaculation
Authors: Liu Jishuang , Bao Tong , Wang Qunfeng , Jiang Hui , Zhang Xiansheng
Published: January 2024

Background
Although men with premature ejaculation (PE) always show more negative emotions, including embarrassment, guilt and worry, this may be related to the stigma of PE. To investigated stigma and its associations with self-confidence and sexual relations in 4 PE syndromes, a survey was conducted in our hospital from December 2018 to December 2019 enrolled 350 men with self-reported PE and 252 men without self-reported PE. The stigma, self-confidence and sexual relations were assessed by the Social Impact Scale (SIS) and Self-Esteem and Relationship questionnaire (SEAR), respectively. Ejaculation control, sexual life satisfaction and distress caused by PE were evaluated by the Index of PE.
Results
In the 2 groups, men with self-reported PE scored higher of internalized shame and social isolation and lower of SEAR. The highest score of internalized shame and social isolation and the lowest score of SEAR appeared in men with lifelong PE (LPE). After age adjustment, the positive relationships were stronger between distress about PE and internalized shame;Whereas, the stronger negative associations were found between social isolation and sexual satisfaction. Importantly, the negative correlation between internalized shame and self-confidence was strongest in LPE. Similarly, the strongest association was observed between social isolation and sexual relationship. Therefore, stigma of PE has certain negative effects on self-confidence, self-esteem and sexual relations of men with PE.
Conclusion
Men with PE, especially LPE, have a high level of stigma and disharmonious sexual relations, and often lack self-confidence and self-esteem, which have a certain negative impact on their physical and mental health and life. These will be the key issues to be considered when we formulate a personalized treatment plan for PE.
Co-infection of Fowl Cholera with bacterial and viral infection in poultry flocks
Authors: Ookanti Srikanth , Bandla Sai Suresh , Y Vimala , B Mathivanan
Published: January 2024

This study explores the co-infection dynamics of Pasteurella multocida (P.multocida) in poultry, focusing on Avian Leukosis Virus (ALV), Mycoplasma gallisepticum (MG), and Chicken Anemia Virus (CAV). Co-infections pose significant challenges to poultry health, leading to increased morbidity and mortality rates. The combined impact of co-infection exacerbates respiratory issues, weakens the immune system, and leads to intricate clinical manifestations. Samples from poultry flocks in Telangana and Haryana states of India, suspected for fowl cholera, were collected during 2019–2021. The study confirms co-infections using conventional PCR techniques targeting specific gene regions. Clinical symptoms exhibited by infected birds are described for each pathogen. The epidemiology of co-infections is discussed, and the importance of understanding these dynamics for effective control and prevention strategies is emphasized. Results reveal consistent co-infections over the study period, highlighting the need for further investigations into associations with parasites, bacteria, fungi, or viruses. The study underscores the importance of comprehensive biosecurity measures, vaccination programs, and early detection for managing poultry co-infections and ensuring sustainable production.
Beyond traditional metrics: A novel method for measuring mood instability in bipolar disorder
Authors: Sperry Sarah , Yocum Anastasia , McInnis Melvin
Published: January 2024

Background: Clinical care for bipolar disorder (BD) has a narrow focus on prevention and remission of episodes with pre/post treatment reductions in symptom severity as the ‘gold standard’ for outcomes in clinical trials and measurement-based care strategies. The study aim was to provide a novel method for measuring outcomes in BD that has clinical utility and can stratify individuals with BD based on mood instability.
Methods: Participants were 603 with a BD (n=385), other or non-affective disorder (n=71), or no psychiatric history (n=147) enrolled in an intensive longitudinal cohort for at least 10 years that collects patient reported outcomes measures (PROMs) assessing depression, (hypo)mania, anxiety, and functioning every two months. Mood instability was calculated as the within-person variance of PROMs and stratified into low, moderate, and high thresholds, respectively.
Outcomes: Individuals with BD had significantly higher mood instability index’s for depression, (hypo)mania, and anxiety compared to psychiatric comparisons (moderate effects, p’s<.001) and healthy controls (large effects, p’s<.001). A significantly greater proportion of individuals with BD fell into the moderate (depression: 52·8%; anxiety: 51·4%; (hypo)mania: 48·3%) and high instability thresholds (depression: 11·5%; anxiety: 9·1%; (hypo)mania: 10·8%) compared to psychiatric comparisons (moderate: 25·5 – 26·6%; high: 0% - 4·7%) and healthy controls (moderate: 2·9% - 17·1%; high: 0% - 1·4%). Being in the high or moderate instability threshold predicted worse health functioning (p’s < .00, small to large effects).
Interpretation: Mood instability, as measured in commonly used PROMs, characterized the course of illness over time, correlated with functional outcomes, and significantly differentiated those with BD from healthy controls and psychiatric comparisons. Results suggest a paradigm shift in monitoring outcomes in BD, by measuring mood instability as a primary outcome index.
Recombinant hirudin regulates macrophage polarisation status through PAR-1 in diffuse large B-cell lymphoma
Authors: Pei Qiang , Li Zihui , Zhao Jingjing , Zhang Haixi , Qin Tao , Zhao Juan
Published: January 2024

Background
Diffuse large B-cell lymphoma (DLBCL) is a malignant tumour. Although some standard therapies have been established to improve the cure rate, these therapies are still ineffective in some patients. Therefore, it is meaningful to look for more novel therapeutic approaches. Macrophage polarisation is extensively involved in the process of tumour development. Recombinant hirudin (rH) affects macrophages and has been researched frequently in clinical trials lately. Our article validates the regulatory role of rH in macrophage polarisation and the regulatory pathways by collecting clinical samples and subsequently establishing a cellular model to provide a scientifically supported viewpoint for discovering new therapeutic approaches.
Method
Initially, we assessed the expression of macrophage polarisation markers, inflammatory factors and PAR-1 in clinical samples. Then, we established a cell model by co-culture and determined the degree of cell polarisation and expression of validation factors by flow cytometry, ELISA, and RT-qPCR to confirm the success of the cell model. Subsequently, different doses of rH were added to discover the function of rH on cell polarisation. Finally, we confirmed the mechanism of rH in macrophage polarisation by transfecting si-PAR-1 and pcDNA3.1-PAR-1.
Results
We found higher expression of M2 macrophage markers (CD163 + CMAF+) and PAR-1 in 30 DLBCL samples. After inducing monocyte differentiation into M0 macrophages and co-culturing with OCI-Ly10 lymphoma cells, we found a trend of these expressions in the cell model consistent with the clinical samples. Subsequently, we discovered that rH promotes the polarisation of M1 macrophages but inhibits the polarisation of M2 macrophages. Later, we also found that rH regulates macrophage polarisation through PAR-1, inhibiting cell proliferation, migration, invasion and angiogenic capacity.
Conclusion
rH inhibits macrophage polarisation towards the M2 type and regulates polarisation, proliferation, migration, invasion, and angiogenesis of DLBCL-associated macrophages through PAR-1.
sST2 augments the prognostic value of simplified risk stratification in patients with connective tissue disease-associated pulmonary arterial hypertension: a single-center retrospective study
Authors: Ye Huangshu , Sun Xiaoxuan , Ma Hong , Zhou Zhangdi , Wang Qiang , Zhou Yanli , Gu Lei , Zhang Miaojia
Published: January 2024

Background
The simplified risk stratification tool from the 2018 WSPH has become widely accepted for evaluating the severity of conditions in patients with pulmonary arterial hypertension (PAH) and plays a crucial role in guiding treatment. In this study, we aimed to explore the value of soluble suppression of tumorigenicity 2 (sST2) in assessing the prognosis of connective tissue disease-associated PAH (CTD-PAH) patients based on simplified risk stratification.
Methods
Based on the inclusion and exclusion criteria, a total of 84 patients with CTD-PAH diagnosed by right heart catheterization were enrolled in this study. A retrospective chart review was completed to assess the clinical presentation and laboratory test results of the patients. The baseline risk stratification of all patients was assessed using the simplified risk stratification model proposed by the 2018 WSPH. The endpoint of the study was clinical worsening. Survival rates were evaluated using Kaplan‒Meier analysis, and differences between the groups were compared using the log-rank test.
Results
(1) Patients classified as intermediate or low risk demonstrated no difference in the event-free survival rate. (2) A sST2 concentration ≥ 35 ng/mL can predict the occurrence of clinical worsening events in low- and intermediate-risk patients. (3) The event-free survival rate was significantly lower in patients whose sST2 levels were maintained or increased to > 35 ng/mL within 1 year.
Conclusion
sST2 enhances the prognostic value of simplified risk stratification in patients with CTD-PAH, most notably in the intermediate-risk group. Furthermore, variations in sST2 levels may predict the clinical prognosis of this disease.
Phenolic Profile, Bioactive Compounds And Antioxidant Properties Of Different Dried Prunes Consumed In Algeri
Authors: Benattouche Zouaoui , Belkhodja Hamza , Bouhadi Djilali , Elouissi Abdelkader , Hariri Ahmed
Published: January 2024

Prunes are a rich source of bioactive compounds and functional constituents that are beneficial to human health. However, the short shelf life of these fruits can be a major cause of postharvest losses especially during peak harvesting season. Drying is one of the most convenient technologies for the production of shelf stable food products. This study investigated the effect of three drying methods (solar, oven, and vacuum) on the phenolic profile, bioactive compounds and antioxidant properties of dried prune and to identify potential benifits use as a preservation method. The results showed that the solar dried prune had the highest retention of polyphenol and flavonoids compounds than oven and vacuum dried prunes. The results also showed that potassium, total-carotene content and antioxidant capacity have significant increase in oven and vacuum dried prunes in comparison with fresh plum and solar dried prune.These results findings indicate that vacuum dried prune is appropriate to maintain high free radicals scavenging compouds and to find its good conservation.
Application of a Novel Model Reduction Technique to the Assessment of Boundedness/Stability of Some Delay Time-Varying Vector Nonlinear Systems
Authors: Pinsky Mark A.
Published: January 2024

This paper develops a new approach to the assessment of the boundedness/stability of some vector nonlinear systems with delays and variable coefficients. The approach rests on the development of scalar counterparts to the original vector systems. We show that the solutions to these scalar auxiliary nonlinear equations with delay and variable coefficients bound from the above the norms of solutions to the original equations with the matched history functions. This prompts the assessment of the boundedness/stability traits of the vector systems through the abridged evaluation of the dynamics of their scalar counterparts. The latter task is achieved in effortless simulations or through the application of simplified analytical inferences. Consequently, we convey some novel boundedness/ stability criteria and estimate the radiuses of the balls imbedded in the boundedness/stability regions. Lastly, we authenticate our inferences in representative simulations that also measure their accuracy. This prompts the evaluation of the boundedness/stability properties of nonautonomous VNDS through the assessment of dynamics of their scalar counterparts that can be triggered in effortless simulations or abridged analytical reasoning. Consequently, we derive some novel boundedness/stability criteria and estimate the radiuses of the balls that are immersed in the boundedness/stability regions of the original systems. Lastly, we authenticate the developed approach in representative simulations that also measure the accuracy of these techniques. This paper is organized as follows. The next section outlines our notation, some preliminary statements, and defines the underlined system. Section 3 ascribes the reduction technique and its applications to the evaluation of the boundedness/stability of some VNDS with variable coefficients. Section 4 presents a closed-form stability criterion. Section 5 discusses the applications of linearized auxiliary equations. Section 6 highlights the results of our simulations, and Section 7 concludes this study and outlines some directions for subsequent research.
Effect of single-radius design on in vivo kinematics during stair activities after total knee arthroplasty
Authors: Kono Kenichi , Yamazaki Takaharu , Tamaki Masashi , Isibashi Teruya , Tanaka Sakae , Tomita Tetsuya
Published: January 2024

Background: The single-radius design is one of the major total knee arthroplasty (TKA) designs and widely used all over the world. The objective of this study was to compare in vivo kinematics between the anteroposterior (AP) single-radius design with mediolateral (ML) single-radius (Non Restricted Geometry; NRG) and ML dual-radius (Triathlon) during stair activities.
Methods: A total of 21 knees in 18 patients (NRG group: 10 knees in 7 patients, Triathlon group: 11 knees in 11 patients) with a clinically successful posterior stabilized TKA were examined. Under fluoroscopic surveillance, each patient performed stair ascending and descending motions. In vivo kinematics were analyzed using 2D/3D registration technique. The knee flexion angle, rotation angle, varus-valgus angle, AP translation of the femorotibial contact point for both the medial and lateral sides of the knee, and post-cam engagement were evaluated.
Results: There were no significant differences between the two groups in rotation angle and AP translation at each flexion angle. Examining the varus-valgus angle, the NRG group showed varus position at an early flexion angle during both stair activities.
Post-cam engagement was observed in both groups during both stair activities. The mean flexion angle of engagement in the NRG group, the post of which was located anterior to the Triathlon, was larger than that in the Triathlon group during both stair activities.
Conclusion: Despite the same AP single-radius TKA, ML single-radius might affect varus motion at an early flexion angle.
Prevalence of canine hepatopathy among a clinic population fed commercial dry food: Age and Dietary factors influence the disease prevalence
Authors: Moosavian Hamidreza , Rezaei Sajad , Jamshidi Shahram , Fazli Mahsa
Published: January 2024

Background: The quality of pet food and feed management can have a pivotal role in the healthy status and the prevention of diseases in animals. The objective of this study was to explore the prevalence of hepatopathy in dogs based on the liver enzyme profile and the association between liver enzyme alterations with diet.
Results: This was a hospital-based, cross-sectional study. We analyzed the history and medical records of all dogs fed commercial dry food presented at a veterinary hospital. A complete physical examination, laboratory survey, and abdominal ultrasonography were performed on each subject. 720 dogs were included in this study. The patients consisted of 385 male dogs (53.5%) and 335 female dogs (46.5%) and the mean age ± SE was 5.92 ± 0.18 years (range, 1 to 17). The overall prevalence of hepatopathy in all dogs fed commercial dry food was 23.8%, 8.3%, and 3.7% based on the mild, moderate, and marked liver enzyme activity elevation (ALT and/or GGT), respectively and statistical analysis exhibited that the factors significantly related to hepatopathy were increasing age and diet type. A significant relationship was observed between age and ALT (Odd ratio: 1.121, CI: 1.064-1.181) and GGT (Odd ratio: 1.056, CI: 1.008-1.105). There was a significant relationship between commercial food brands and some biochemical factors including ALT, AST, GGT, ALP, Chol, and total bilirubin.
Conclusion: In summary, our findings suggest that hepatopathy in dogs appears to be more common than previously thought, and aging and type of diet are risk factors for liver disease in dogs. Therefore, using good-quality diets will likely play an essential role in preventing liver disorders in dogs.
Effects of heat stresses on fitness of three commercial predatory mites
Authors: Hao Xuemin , Wang Endong , Yan Hong , Zhao Peipei , Sheng Fujing , Ren Qin , Liu Meike , Zhang Bo , Xu Xuenong
Published: January 2024

To explore the performances of predatory mites under high temperature, we selected three predatory mites Amblyseius orientalis, Neoseiulus californicus and Neoseiulus barkeri to investigate the survival rate, development duration and fecundity after their eggs and female adults were treated with high temperatures. The results showed that both eggs and adults of N. barkeri were most tolerant to heat stress than N. californicus and A. orientalis. After heat treatment of 39°C on egg, three predatory mites all presented shorter developmental period and longevity as well as lower fecundity. The oviposition period of N. californicus was shortened by nearly 50% and the total egg production of A. orientalis decreased by about 40%. However, the N. barkeri was the least affected by high temperature with its fecundity reduced by only 30%. The short-term high temperature treatment at adult stage also had negative effect on the oviposition period and longevity. The oviposition period of A. orientalis was reduced from 18.26 days to 3.82 days at 39℃, and 100% mortality occurred at 40°C. The longevity of N. californicus and N. barkeri suffered at 40℃ was shortened by about 50%. Our study confirmed that N. barkeri is tolerant to high temperatures at some extent, while A. orientalis is more heat sensitive in either two life stage. In sum, the understanding of the heat resistance of commercial predatory mites can improve the better application of biocontrol agents when selecting mite species for pest mite control in the field.
Man sieht nur, was man kennt. Unterscheidung zwischen Stellaria ruderalis und den anderen Arten der Stellaria-media-Gruppe
Authors: Frank Dieter , John Heino
Published: January 2024

Die makroskopisch erkennbaren Unterscheidungsmerkmale der vier in Mitteleuropa vorkommenden Arten des Stellaria-media-Aggregats werden vorgestellt und diskutiert. Schwerpunkt bildet die Abgrenzung von S. neglecta zu S. ruderalis und von S. media zu S. ruderalis. Relevante Unterscheidungsmerkmale werden durch Abbildungen veranschaulicht.
MANAGEMENT OF IRRITABLE BOWEL SYNDROME THROUGH AYURVEDA- A CASE REPORT
Authors: P. Adarsh
Published: January 2024

Irritable bowel syndrome (IBS) is one of the most common conditions encountered in clinical practice. IBS is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating and alteration of bowel habits in the absence of any organic cause. Certain psychological symptoms are also more common in patients with IBS. Diarrhea and constipation may predominate or they may alternate in cases. Psychological factors like stress, anxiety etc. plays an important role in development of IBS. IBS in Ayurveda can be correlated with conditions like Grahani, Atisara, Pravahika and Acharya Charaka has told about the inter dependance of Shareerika and Manasika Doshas. In this case, an effort has been made to treat a 21-year-old female patient having symptoms like Diarrhea immediately after food followed by constipation for 3-4 days alternatively along with bloating of abdomen, epigastric pain, weight loss and anxiety. Patient took Panchakola Yavagu, Kaidaryaadi kashayam, Kalashakaadi Kashayam and Manasamitravatakam and Shatphala Grutham for a period of 90 days which resulted in improvement of symptoms. Improvement of symptoms were accessed as per IBS symptom severity score, IBS quality of life questioner, Bristol stool chart, Hamilton anxiety rating scale and Hamilton depression rating scale pre and post treatment.
THE RESULT OF THE USE OF PROBLEM SOLVING METHODOLOGIES IN ORGANIZATIONS THIS ARTICLE IS BASED ON THE RESULTS OBTAINED IN THE DOCTORAL THESIS OF THE SAME AUTHOR ENTITLED HOW DO THE INDICATORS OF THE ADMINISTRATIVE AREAS OF COMPANIES EVOLVE DUE TO THE USE OF PROBLEM-SOLVING METHODOLOGIES?
Authors:   Saltillo (Mexico)., Ruben Lostal Martinez Felix
Published: January 2024

This article deals with the use of problem solving methodologies and how these positively affect the performance of KPI (Key Process Indicator) of organizations, clearly showing that those organizations that use these methodologies obtain better results over those who do not use them. With this work, what is sought is to question the myth, and put an end to the axiom that it was something taken for granted and confirm with statistical data the truth that methodologies work to improve the performance of organizations, as long as they are applied by teams trained in them. Leaving aside that the use of these methodologies is somewhat punctual to solve quality or production problems and that they must be used in the entire spectrum of organizations.
A CRITICAL STUDY ONPURUSHAANDSRISHTI UTPATTI KRAMA- A REVIEW ARTICLE
Authors:   Assistant Professor, Dept. of Sharir Rachana, SBLD Ayurved Vishwa Bharti, Sardarshahar., Sewada Deepak , Sharma Mahendra ,   Professor, & HOD, P.G. Dept. of Sharir Rachana, University P.G. Institute of Ayurveda, Jodhpur., Sagwan Neelam ,   Associate Professor, Dept. of Sharir Rachana, Shekhawati Ayurved Medical College and Hospital Pilani., a Ankita ,   Associate Professor, Dept. of Kriya Sharir, University P.G. Institute of Ayurveda, Jodhpur.
Published: January 2024

While studying Ayurveda we come across the concept of Srishti Utpatti Krama, Purusha etc. as a beginner everybody feels why we have to study this, for being a physician clinician. But this concept has a large role in the field of Chikitsa(Treatment). Ayurveda mentioned the term Purushafor Chetana Dhatu or Atma. The termPurushahas combination of twowords: Pura and Shayana, here Pura refers to the body and Shayana refers for residing. Creation is the transformation of cause to effect and dissolution is the reverse process. The principle cause of every material in the universe is Moolaprakriti/Avayakta/Unmanifest. The manifested matter is called Vyatka. Thus creation is the evolution of Avayakta to Vyakata. So in this article attempt is made to understand the topic and its relevance treatment modality.
EXAMINING THE RELATIONSHIP BETWEEN TIME SPENT ON SOCIAL MEDIA AND ACADEMIC PERFORMANCE
Authors:   Assistant Professor, Department of Sociology, Lovely Professional University, Phagwara, Punjab., Shekhar Singh Chandra , Kumar Ajay ,   Research Scholar, Department of Sociology, Lovely Professional University Phagwara, Punjab.
Published: January 2024

In the contemporary era, social media have become an essential part of day-to-day existence, especially among college students, who are by and large, predominant social media users. However, social media performing multiple tasks has likewise been progressively common. Nonetheless, there is a scarcity of evidence about how social media impacts the learning performance of college students, particularly in Chenab Valley of Jammu region of J&K. This study analyzed how usage and time spent on social media enhance undergraduate students performance in Chenab Valley colleges. The study is based on primary data, which has been collected from two Govt. colleges in Chenab valley. Further, the study has chosen 100 undergraduate students from two colleges 50 students from each. The finding demonstrates that 81% of students who use social media belong to rural areas and 19% who use social media belong to urban areas. Further, the result also shows that in urban areas, the majority of the female respondents (74%) use various kinds of social media than males (26%). It also reveals that the majority of the respondents (59%) agree that their academic grade is significantly enhanced by using social media. However, respondents mostly use YouTube for academic purposes.
A RANDOMISED CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFECT OF SHATAPUTI ABHRAKA BHASMA IN KSHEENA RETAS VIS-A-VIS OLIGOSPERMIA
Authors:   Final Year PG Scholar, Department of PG Studies in Kayachikitsa, Government Ayurveda Medical College, Mysuru, Karnataka, India., Basaiah Matapathi Veeranna , Kumar M.D Sanjay ,   Professor, Department of PG Studies in Kayachikitsa, Government Ayurveda Medical College, Mysuru, Karnataka, India.
Published: January 2024

Background: Ksheena retas is a condition where Shukra is moderately decreased, especially in the middle age due to etiology undefined in this type, the body growth, pubertal development and level of Shukra may be normal initially until the etiological factors bring about a fall.Here the cause could be Aharajanya (Katu, Kashaya Rasa), Viharajanya (Abhighata), Vyadhikarshaaa etc. it leads to qualitative or quantitative decrease in the retas.In the present context ksheenaretas can be taken as quantitative decrease in the sperm count. Oligospermia is defined as a reduction in the sperm count below 20 million. it is a major cause of male infertility which is characterized by reduced level of sperm. In the literature, it is mentioned as alpamatrasnehapana (24ml) act as deepana and vrishya.Shataputi Abhraka Bhasma is mentiond as param vrushya and shukrala in the literature in the present study this ShataputiabhrakaBhasma is administerd as trial drug. so an attempt was made in the present study to evaluate the efficacy of shataputi Abhraka Bhasma in trial group B and shatavaryadigritha(indigenous formulation) in control group A. Objective:To evaluate the effect of ShataputiAbhraka Bhasma in ksheenaretas vis-a-vis Oligospermia. Method: It is a Randomised controlled clinical study with pre and post-test design. Shatavaryadighrita (indigenous formulation) prepared was administerdin group A for 30 days. AndShataputiabhraka Bhasmain group B for 30 days. Results: Mean sperm count of 13.125mill/ml was increased in control group A and mean sperm count of 2.7143mill/ml was decreased in trial group B after the intervention. Conclusion: it can be concluded from the result that control drug shatavaryadigritha is effective in the management of Ksheena retas and Shataputi Abhraka Bhasma proved insignificant.
SIX SIGMA METRICS: INDICATOR OF QUALITY ASSURANCE FOR CLINICAL BIOCHEMSITRY
Authors:   Assistant Professor, Government Medical College, Akola., N. Chitlange (Kasat) Shilpa , A. Jungare Shamali ,   Associate Professor, Government Medical College, Akola., G. Ghangale Suresh ,   Professor and Head, Government Medical College, Akola.
Published: January 2024

Introduction: In present scenario Quality is the important aspect of laboratory practices. Mostly internal and external quality control are utilized to maintain quality in laboratory. Quality assurance of laboratory services is the need of present time in health care which require Quality Planning, Quality Control (QC), Quality Assessment (QA) and Quality Improvement . Aims & Objectives: 1. To quantify the defects and errors in analytical phase of laboratory testing by sigma metrics and to represent the calculated sigma value. 2. Application of six sigma test in laboratory with the IQC and EQAS to maintain quality laboratory services. Methodology: Study was conducted at Clinical Biochemistry Laboratory, GMC Akola. We run IQC samples on daily basis and EQAS samples are running on monthly basis. Retrospectively we utilized data of IQC and EQAS from January to October 2023 for 16 Biochemical Analytes. Sigma metrics for each parameter was calculated. Result: The sigma metrics for IQC indicated that 1 out of 16 analytes qualified six sigma quality performance. Of these 15 analytes performance with sigma metrics was beteween three and six. We found different sigma value like more than6 for only HDL cholesterol and more than 3 for Amylase, Total Bilirunbin, Creatinine, Cholesterol, Glucose, Phosphorus, total Protein , SGPT , TG, UA, Urea, SGOT, which is among the acceptable range of performance. Conclusion: In our study sigma value was highest for HDL cholesterol and other 15 analytes show sigma value between 3 to 6 which is acceptable range. Sigma analysis is a continuous procedure and by taking the help of method decision chart we can improve on decision on making in clinical chemistry laboratory regarding optimising QC procedure.
SMART TRAFFIC LIGHTS USING IOTTECHNOLOGIES : PROJECT CONCEPT AND PROGRESS
Authors:   Institut Universitaire de Technologie, Universite Iba Der Thiam, Thies, Senegal., Sow Ousmane , Traore Youssou ,   Institut Universitaire de Technologie, Universite Iba Der Thiam, Thies, Senegal., Andallah Diop Mame ,   Institut Universitaire de Technologie, Universite Iba Der Thiam, Thies, Senegal., Sadikh Faye Ababacar ,   Universite Iba Der Thiam, ED2DS, Thies, Senegal., Ndiaye Jupiter ,   Universite Iba Der Thiam, ED2DS, Thies, Senegal., Diop Abdoulaye ,   Universite Iba Der Thiam, ED2DS, Thies, Senegal.
Published: January 2024

The rural exodus and population growth has led to the rapid expansion of cities without sometimes developing road infrastructure. This situation is at the origin of congestion in road traffic with a very high number of vehicles. In Africa, cities that have the financial means often use traffic lights with a predefined traffic plan which can be ineffective at sometimes of the day. In this paper, we propose a concept of wireless traffic light terminal, connected and self-sufficient in energy, for installation at intersections without public works on the road. This traffic light terminal is accessible remotely from police stations for its supervision and control. Thus, traffic management at an intersection is carried out remotely and in real time by an agent who selects a traffic plan adapted to the current situation. The objective is to centralize, with few personnel, the management of several intersections equipped with traffic light terminals, for better overall regulation of road traffic at low costs. Our work resulted in a proof of concept, for a four-lane crossroads, made with four Arduino electronic boards, four Lora wireless modules, a Raspberry-pi microcomputer, a camera and a 4G modem. For the software part, a server application developed with the node-red language, on the Raspberry-pi electronic card, provides the graphical interface for monitoring and control. The proposed system integrates a Cloud service that makes the human-machine interface for supervision and control remotely accessible via the Internet.
DİJİTAL İÇERİK VE HİZMETLERİN SUNULMASINA İLİŞKİN SÖZLEŞMELERDE GÜNCELLEME YÜKÜMLÜLÜĞÜ
Authors: Han İşik Asli
Published: January 2024

Gelişen teknoloji ve pazardaki yoğun rekabetin etkisiyle dijital ürünler hızla güncelliğini ve kullanım yararını kaybetmektedir. Üstelik tüketiciler temin ettikleri dijital ürünün gelecekte kullanım beklentilerini karşılayıp karşılayamayacağı noktasında sözleşme kurulduğu anda bilinçli bir tercih yapamazken, sektörel rekabetin düzeyi ve teknolojinin gelecek yıllardaki görünümü hakkında bilgiye dayalı tahminlerde bulunabilen üreticiler kâr payını arttırmak pahasına güncelleme desteğini -en iyi ihtimalle- kademeli olarak azaltarak ürünün kullanım yararının zedelenmesine neden olmaktadır. Bu nedenle dijital ürünlerin bir yandan zaman içinde teknolojik gelişmelere uyum sağlayabilmesi ve tüketicinin makul beklentilerinin korunabilmesi diğer yandan ise güvenlik açıklarına karşı tüketicilerin verilerinin korunabilmesi için öngörülen güncelleme yükümlülüğü, yeni Avrupa Birliği tüketici hukuku mevzuatında 2019/770 ve 2019/771 sayılı Direktiflerin hukuk çevresi açısından nötr kelime seçimiyle sözleşmeye uygunluk (conformity), yani Romanogermanik hukuk terminolojisiyle ayıba karşı tekeffül (Mängelgewährleistung) sorumluluğu kapsamında düzenlenmiştir. Bu kapsamda sözleşme tarafı girişimci, dijital içerik veya hizmeti geliştiren üretici olsun veya olmasın, dijital ürün üzerinde gerekli güncellemelerin yapılmamasından sorumlu tutulmuştur. Çalışmada güncelleme yükümlülüğünün tüketici ve dijital ürün pazarının diğer aktörleri arasındaki bilgi ve güç asimetrisini giderme fonksiyonu, taraflar arasındaki menfaat dengesi ışığında güncelleme yükümlülüğünün kapsamı ve ihlalin sonuçları önce yeni Avrupa Birliği mevzuatı ışığında incelenecektir. Bunu takiben, dijital ürünlerin sunulmasına ilişkin özel hükümlerin bulunmadığı Türk hukukunda, güncelleme yükümlülüğünün tüketicilere sağladığı hukuki korumanın, açık bir düzenleme ile öngörülene dek başka hangi hukuki dayanaklarla sağlanabileceği ve buna bağlı olarak ihlalin sonuçları, Avrupa Birliği mevzuatında ilgili hükümlere getirilen eleştiriler (özellikle güncelleme yükümlülüğünün esas muhatabı ve sorumlunun farklı kişiler olduğu hallerde tüketicinin sahip olduğu hukuki imkanlar ve tedarik zinciri içindeki rücu mekanizmasının işlevsel olup olmadığı noktalarında) ışığında incelenecektir.
Urine specific gravity as an indicator for the determination of urinary GGT in dogs with visceral leishmaniasis
Authors: Gomes de Oliveira Gustavo , Rosa de Oliveira Maia Juliana , de Oliveira Frazilio Fabiano , Alves Franco Polliana , Izabel de Souza Alda
Published: January 2024

The urinary Gama-Glutamyl Transpeptidase to urinary Creatinine ratio (uGGT/uCR) is a laboratory marker that may signal renal tubular lesion in dogs with visceral leishmaniasis (VL). In this study, our goal was to determine whether urine specific gravity (USG) can accurately indicate an elevated uGGT/uCR and, consequently, tubular injury. Twenty-eight animals with VL and five healthy animals (control group) were included in the study. The diseased animals were classified as azotemic (n = 6) and non-azotemic (n = 22). The difference between all groups was tested with the Kruskal-Wallis test for the USG, uGGT/uCR, and urine protein: creatinine ratio (UPC). Sensitivity, specificity, positive and negative predictive value and the accuracy of using USG as an indicator of tubular injury were calculated with the Receiver Operating Characteristic (ROC curve). The probability of an animal with suboptimal USG presenting tubular injury was obtained by calculating the prevalence ratio. The Kruskal-Wallis test revealed differences between groups for all analyzed parameters (p< 0.05). The chosen USG cut-off value, determined by the ROC curve was 1.030, with an accuracy of 78.09%. The probability of a dog with LV and USG below 1.030 having a high uGGT/uCR ratio was 4.95 (p <0.01, 95% CI - 1.32-18.48) when compared to individuals with ideal DU. In conclusion, dogs positive for Leishmania sp. with low USG (<1.030) should have their uGGT/uCR ratio measured to verify the presence of tubular injury even before the onset of azotemia.
Nanoceria Anti-inflammatory and Antimicrobial Nanodrug: Cellular and Molecular Mechanism of Action
Authors: Gomes-da-Silva Natalia Cristina , Correa Luana Barbosa , Gonzalez M. MartInez , Silva Franca Alefe Roger , Alencar Luciana M.R , Rosas Elaine Cruz , Ricci-Junior Eduardo , Aguiar Tawanny Kayonara Borges , Noronha Souza Pedro Filho , Santos-Oliveira Ralph
Published: January 2024

Introduction:

Nanoceria is a well-known nanomaterial with various properties, including
antioxidant, proangiogenic, and therapeutic effects. Despite its potential, there are still aspects
that require further exploration, particularly its anti-inflammatory and antimicrobial activities.

Methods:

The global demand for novel anti-inflammatory and antimicrobial drugs underscores
the significance of understanding nanoceria in both contexts. In this study, we evaluated the effect
of nanoceria on macrophage polarization to better understand its anti-inflammatory effects. Additionally,
we investigated the mechanism of action of nanoceria against Cryptococcus neoformans
(ATCC 32045), Candida parapsilosis (ATCC 22019), Candida krusei (ATCC 6258), and Candida
albicans.

Results:

The results demonstrated that nanoceria can polarize macrophages toward an anti-inflammatory
profile, revealing the cellular mechanisms involved in the anti-inflammatory response.
Concerning the antimicrobial effect, it was observed that nanoceria have a more pronounced impact
on Candida parapsilosis, leading to the formation of pronounced pores on the surface of this
species.

Conclusion:

Finally, biochemical analysis revealed transitory alterations, mainly in liver enzymes.
The data support the use of nanoceria as a potential anti-inflammatory and antimicrobial
drug and elucidate some of the mechanisms involved, shedding light on the properties of this nanodrug.
Enzyme Cocktails Catalyzed Bioconversion of Lignocellulosic Biomass into
Bioethanol
Authors: Dai Tianlun , Huang Jinshu , Wu Hongguo , Li Hu
Published: January 2024

Sustainable production of biofuels from lignocellulosic biomass (LBM) is considered
one of the promising solutions to solve the current energy crisis caused by overreliance
on fossil fuels. Enzymatic hydrolysis is a crucial step in determining the efficient
conversion of biomass cellulose into biofuels as well as high value-added chemicals, and
it has the characteristics of efficient reaction, economy, and environmental friendliness.
With the advancement of enzyme engineering technology, enzymes have been endowed
with more functions, such as mixed substrate utilization, inhibitor resistance and specific
metabolism, called enzyme cocktails. This Paper introduces the typical procedure of enzymatic
hydrolysis of LBM and discusses their applications in hybrid LBM hydrolysis. In
addition, the challenges of enzymatic LBM hydrolysis and possible development directions
are outlined to guide integrated enzymatic strategies in biorefinery processes.
The Search for Antidotes Against Ricin
Authors: Botelho Fernanda Diniz , Franca Tanos Celmar Costa , LaPlante Steven R.
Published: January 2024

The castor plant (Ricinus communis) is primarily known for its seeds, which contain a
unique fatty acid called ricinoleic acid with several industrial and commercial applications. Castor
seeds also contain ricin, a toxin considered a chemical and biological warfare agent. Despite years
of investigation, there is still no effective antidote or vaccine available. However, some progress has
been made, and the development of an effective treatment may be on the horizon. To provide an
updated overview of this issue, we have conducted a comprehensive review of the literature on the
current state of research in the fight against ricin. This review is based on the reported research and
aims to address the challenges faced by researchers, as well as highlight the most successful cases
achieved thus far. Our goal is to encourage the scientific community to continue their efforts in this
critical search.
Current Trends in Nanotechnology-Based Drug Delivery Systems for the
Diagnosis and Treatment of Malaria: A Review
Authors: Deshmukh Rohitas , Dewangan Bhuvaneshwari , Harwansh Ranjit K. , Agrawal Rutvi , Garg Akash , Chopra Himansu
Published: January 2024

Malaria is still a major endemic disease transmitted in humans via Plasmodium-infected
mosquitoes. The eradication of malarial parasites and the control measures have been rigorously and
extensively deployed by local and international health organizations. Malaria's recurrence is a result
of the failure to entirely eradicate it. The drawbacks related to malarial chemotherapy, non-specific
targeting, multiple drug resistance, requirement of high doses, intolerable toxicity, indefinable complexity
of Plasmodium's life cycle, and advent of drug-resistant strains of P. falciparum are the causes
of the ineffective eradication measures. With the emergence of nanotechnology and its application
in various industrial domains, the rising interest in the medical field, especially in epidemiology, has
skyrocketed. The applications of nanosized carriers have sparked special attention, aiming towards
minimizing the overall side effects caused due to drug therapy and avoiding bioavailability. The
applications of concepts of nanobiotechnology to both vector control and patient therapy can also be
one of the approaches. The current study focuses on the use of hybrid drugs as next-generation antimalarial
drugs because they involve fewer drug adverse effects. The paper encompasses the numerous
nanosized delivery-based systems that have been found to be effective among higher animal
models, especially in treating malarial prophylaxis. This paper delivers a detailed review of diagnostic
techniques, various nanotechnology approaches, the application of nanocarriers, and the underlying
mechanisms for the management of malaria, thereby providing insights and the direction in
which the current trends are imparted from the innovative and technological perspective.
The Impact of Polypill on Adherence and Cardiovascular Outcomes:
A Comprehensive Systematic Review with Meta-Analysis
Authors: Salim Hamza , Musmar Basel , Saifi Motaz , Ayyad Mohammed , Ruzieh Mohammed , Azar Jehad , Nazzal Zaher
Published: January 2024

Background:

Cardiovascular disease (CVD) remains a leading cause of morbidity
and mortality worldwide. Polypills, containing various combinations of medications for primary
and secondary CVD prevention, have been developed to enhance medication adherence and reduce the healthcare burden of CVD. However, their effectiveness compared to usual care remains uncertain.

Objective:

This meta-analysis aimed to evaluate the effects of polypills on cardiovascular risk
factors, major adverse cardiovascular events (MACE), and medication adherence.

Methods:

We conducted a comprehensive search for large-scale randomized controlled trials
and observational studies comparing the effects of polypills versus usual care on CVD risk factors and events. Outcomes included changes in systolic and diastolic blood pressure (SBP,
DBP), lipid profiles, occurrence of MACE, and medication adherence.

Results:

The use of polypills led to a statistically significant yet clinically modest reduction in
SBP (mean difference -1.47 mmHg, 95% CI: -2.50 - -0.44, p<0.01) and DBP (mean difference1.10 mmHg, 95% CI: -1.68 - -0.51, p< 0.01) compared to usual care. Polypills also showed a
significant reduction in the risk of MACE (RR: 0.86, 95% CI: 0.77 -0.95, p<0.01). There was a
non-significant reduction in LDL and HDL levels. Adherence to medication improved by up to
17% in polypill users compared to those on usual care (p < 0.01). A multivariable metaregression analysis suggested that adherence may be the underlying factor responsible for the
observed effect of the polypills on blood pressure.

Conclusion:

Polypills were found to significantly reduce SBP, DBP and MACE. An improvement in medication adherence was also observed among polypill users, which might be responsible for the significant reduction in SBP observed users. Future research might benefit from exploring a more personalized approach to the composition of polypills, which could reveal a more
clinically significant impact of increased adherence on CVD outcomes.
Insights into the Biological Properties of Prostate Cancer Stem Cells: Implications for Cancer Progression and Therapy
Authors: Poodineh Jafar , Akhlaghpour Azimeh , Ghaedrahmati Farhoodeh , Pour Fatemeh Khojasteh , Uddin Shahab , Farzaneh Maryam , Azizidoost Shirin
Published: January 2024

Prostate cancer (PCa) is the second prevalent cancer in men. Recent studies have highlighted
the critical role of prostate cancer stem cells (PCSCs) in driving tumor initiation and metastasis
of the prostate tissue. PCSCs are a rare population of cells in the prostate that possess self-renewal
and differentiation capabilities, making them a potential therapeutic target for effective PCa
treatment. Therefore, targeting PCSCs might be a novel strategy for the treatment of PCs. Research
has shown that various signaling pathways, such as Notch, SHH, TGF-β, Wnt, STAT3,
AKT, and EGFR, are involved in regulating PCSC proliferation, migration, and invasion. Additionally,
non-coding RNAs, such as long ncRNAs and miRNAs, have emerged as critical regulators
of PCSC pathogenesis and drug resistance. Here, we highlight that targeting these pathways could
offer new opportunities for the management of PCa. This review summarizes the current knowledge
surrounding the essential signaling pathways implicated in PCSC tumorigenesis and invasiveness.