bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness and Safety of Anlotinib Monotherapy for Patients with Extensive-stage Small-Cell Lung Cancer Who Progressed to Chemotherapy: A Real-world Exploratory Study
Authors: Li Yonghui , Sun Zhenqing , Sun Wei , Wang Haibo , Zu Jinchi
Published: January 2022

Background:

Anlotinib demonstrated promising efficacy for patients with extensive-stage small-cell lung cancer (ES-SCLC) in clinical trials. However, the real-world evidence of anlotinib monotherapy in ES-SCLC was still limited currently. Therefore, present study was to investigate the effectiveness and safety of anlotinib for patients with ES-SCLC who progressed to chemotherapy in real-world and the potential biomarker during anlotinib monotherapy.

Methods:

A total of 89 patients with ES-SCLC who failed the previous chemotherapy treatment were recruited. All the patients were administered with anlotinib monotherapy. Demographic data of the patients were collected; effectiveness and safety profile during anlotinib monotherapy were documented through electronic medical record system in the hospital. Progression-free survival (PFS) and overall survival (OS) were presented using Kaplan-Meier survival curves and multivariate analysis was adjusted by Cox regression analysis.

Results:

All the 89 patients with ES-SCLC who progressed to chemotherapy were available for the assessment of effectiveness and safety profile. Best overall response indicated that partial response was observed in 6 patients (6.7%), stable disease was noted in 61 patients (68.5%), and progressive disease was found in 22 patients (24.7%). Therefore, the objective response rate (ORR) and disease control rate (DCR) of the 89 patients with ES-SCLC was 6.7% (95% confidence interval [CI]: 2.5%-14.1%) and 75.3% (95% CI: 65.0%-83.8%), respectively. The prognostic data suggested that the median PFS of the 89 patients was 3.1 months (95% CI: 2.10-4.10), and the median OS was 8.6 months (95% CI: 7.42-9.78). In addition, the most common adverse reactions of the patients who received anlotinib monotherapy were hypertension (34.8%), hand-foot syndrome (30.3%), fatigue (29.2%), loss of appetite (27.0%), and hematological toxicity (21.3%). Association analysis between biomarker (hypertension status) and prognosis indicated that the median PFS of patients with hypertension and patients with non-hypertension was 5.5 and 3.0 months, respectively (χ2 = 4.64, P = .031). Furthermore, multivariate Cox analysis for PFS suggested that hypertension status was an independent factor for PFS (hazard ratio [HR] = 0.71, P = .035].

Conclusion:

Anlotinib monotherapy showed encouraging effectiveness and acceptable safety profile for patients with ES-SCLC in real world. Hypertension induced by anlotinib administration might be used as a potential biomarker to predict superior PFS for patients with ES-SCLC.
Learning gain rather than learning loss during COVID-19: A proposal for reframing the narrative
Authors: Chen Jennifer J , Krieger Nora Jane
Published: January 2022

“Learning loss” has become the new buzzword in education during the COVID-19 era. Learning loss may be real in certain academic subjects (e.g. mathematics and reading) for certain students, as indicated by standardized test scores. However, it only tells a partial story. The other part of the story actually indicates different kinds of learning gain that might have occurred for children experiencing non-conventional learning opportunities during the COVID-19 pandemic. Thus, the authors caution against subscribing to a learning-loss narrative, a deficits-based perspective, which can lead one to lose sight of children's potential learning gains that are not necessarily assessed or recognized. Against this backdrop, the authors offer four recommendations: (1) reframing the concept of “learning loss” to “learning gain”; (2) applying a strengths-based model rather than a deficits-based model for understanding student learning; (3) investing in the development of the whole child; and (4) ensuring that we focus on young children's socio-emotional well-being (e.g. relationship-building) and not solely on the cognitive domains.
Spirituality in Occupational Therapy Practice: Where is Our Spirituality Now?
Authors: Pham Loree , Sarnicola Regina , Villasenor Christina , Vu Tiffanie
Published: January 2022

Although occupational therapy (OT) practitioners are well suited to address spirituality within client care, evidence suggests many practitioners feel discomfort or lack of knowledge of this subject. Few studies have delved into OTs’ experiences and encapsulated if and how spirituality has been experienced in practice. This study aimed to gain a deeper and more updated insight into this phenomenon. Utilizing a phenomenological approach with interviews, this study explored OT practitioners’ ( n = 15) experiences with spirituality in client care. (a) Losing spirit: the inadequacy of only addressing mind and body, (b) spirituality as a vehicle for reaffirming purpose in both client and therapist, and (c) addressing spirituality through functional and measurable treatments. Although the concept of mind, body, and spirit is not new, occupational therapists often do not consistently address these components simultaneously, leading to missed opportunities in client practice.
Smartphone and mHealth Use After Stroke: Results From a Pilot Survey
Authors: Burns Suzanne Perea , Terblanche Madeleine , MacKinen Ashley , DeLaPena Catalina , Fielder Jaimee D. P.
Published: January 2022

Advances in smartphone technology have revolutionized health care providing innovative approaches to improve health and well-being. Emerging mobile health (mHealth) apps are becoming increasingly available and offer opportunities to support self-management needs in people with stroke; however, experiences with mHealth among this population are not well understood. The objective of this study is to conduct a cross-sectional survey on smartphone and mHealth app use for adults with stroke. A pilot survey of 50 adults with stroke was conducted. In all, 51% of respondents reported using their smartphone more frequently than before their stroke, and 91% reported having some degree of difficulty with its use. Respondents reported on specific challenges with app use and discussed desired content and features. Occupational therapists should familiarize themselves with valid, accessible, usable, and acceptable apps for people with stroke and consider implementing mHealth apps in self-management intervention plans to improve health, rehabilitation, and community integration outcomes in this population.
‘The spiral just keeps on going’: Cascading health and social issues for women living and aging with HIV
Authors: Herron Lisa-Maree , Mutch Allyson , Mugamu Melania , Howard Chris , Fitzgerald Lisa
Published: January 2022

Background:

There has been limited qualitative inquiry aimed at understanding the gendered and unique experiences of women living with HIV in high-income countries. In Australia, the relatively small number of women living with HIV means they have been largely overlooked in social, clinical, and policy representations of HIV over time.

Objectives:

To explore the experiences of women living long-term and aging with HIV, to understand the complex intersections between their health and social trajectories.

Methods:

Data were collected as part of Living Positive in Queensland, a longitudinal qualitative study of the experiences of living long-term and aging of people living with HIV in Queensland, Australia. This study analysed data from three annual, semi-structured interviews with the 11 female participants.

Results:

Women negotiated gendered roles and identities as they grappled with ongoing and intertwined health and psychosocial challenges over their life course. Development of co-morbidities, experiences of stigma, gendered social roles, financial precarity, and limited social support amplified the challenges of living with HIV and cumulatively impacted women’s health and wellbeing as they aged with HIV.

Conclusion:

The health and wellbeing of women living with HIV are adversely impacted by intersecting complex health issues, HIV-related stigma, gendered identities, social disadvantage, and aging. Greater attention to the unique needs of women living with HIV is necessary to reduce the prevalence of psychological distress, financial stress, and vulnerability to social isolation which, in turn, lead to poorer health.
High-frequency first syllables facilitate name–face association learning
Authors: Headen Bianca A , Venuto Jenna M , James Lori E
Published: January 2022

It is harder to learn a proper name than a common noun in association with a new face, and low-frequency (LF) or rare surnames are harder to learn than high-frequency (HF) or common surnames. A separate body of research has shown that words containing HF phonological components can be easier to retrieve and produce than words with LF phonological components. This study tested for a “downstream” benefit of increased syllable frequency (independent of name frequency) on name–face association learning: surnames with HF first syllables were predicted to be learned more easily than those with LF first syllables. Participants were tasked with learning 5 names with HF first syllables and 5 names with LF first syllables in association with 10 unfamiliar faces over repeated testing rounds with feedback. People learned more names containing HF than LF first syllables, demonstrating a benefit of increased phonological frequency to name learning. Findings support an interactive activation model that accounts for name–face association learning as well as phonological frequency effects on production, along with many other aspects of memory and language.
Cognition and affect in imagined and recalled scenarios as a function of a specificity manipulation: An experience sampling study
Authors: Zabelina Darya L , Jennings Peyton E , Veilleux Jennifer C
Published: January 2022

Previous work has examined the effect of specificity and temporal focus (i.e., memory vs. imagination) on people’s cognition and associated affect. Here, using experience sampling methods, we take these previously addressed questions out of the laboratory into daily-life settings. Participants ( N = 228) were randomly assigned to a specificity or control condition, and recorded imagined or recalled scenarios twice a day for 1 week. Results revealed a main effect of specificity where specificity prompts resulted in written scenarios that were rated by independent judges as more creative, more positive, less negative, more coherent, and incorporated more sensory content. Specificity had few direct influences on affect, though an interaction showed that imagined scenarios with specificity prompts resulted in reduced self-reported anxiety. Implications and future directions are discussed.
Towards the formal performance analysis of multistate coherent systems using HOL theorem proving
Authors: Murtza Shahid Ali , Ahmed Waqar , Rashid Adnan , Hasan Osman
Published: January 2022

Many practical engineering systems and their components have multiple performance levels and failure modes. If these systems form a monotonically increasing structure function (system model) with respect to the performance of their components and also if all of their components affect the overall system performance, then they are said to be multistate coherent systems. Traditionally, the reliability analysis of these multistate coherent systems has been carried out using paper-and-pencil or simulation based methods. The former method is often prone to human errors, while the latter requires high computational resources for large and complex systems having components with multiple operational states. As a complimentary approach, we propose to use Higher-order-logic (HOL) theorem proving to develop a sound reasoning framework to analyze the reliability of multistate coherent systems in this paper. This framework allows us to formally verify generic mathematical properties about multistate coherent systems with an arbitrary number of components and their states. Particularly, we present the HOL formalization of series and parallel multistate coherent systems and formally verify their deterministic and probabilistic properties using the HOL4 theorem prover. For illustration purposes, we present the formal reliability analysis of the multistate oil and gas pipeline to demonstrate the effectiveness of our proposed framework.
Meniscus regeneration by 3D printing technologies: Current advances and future perspectives
Authors: Stocco Elena , Porzionato Andrea , De Rose Enrico , Barbon Silvia , De Caro Raffaele , Macchi Veronica
Published: January 2022

Meniscal tears are a frequent orthopedic injury commonly managed by conservative strategies to avoid osteoarthritis development descending from altered biomechanics. Among cutting-edge approaches in tissue engineering, 3D printing technologies are extremely promising guaranteeing for complex biomimetic architectures mimicking native tissues. Considering the anisotropic characteristics of the menisci, and the ability of printing over structural control, it descends the intriguing potential of such vanguard techniques to meet individual joints’ requirements within personalized medicine. This literature review provides a state-of-the-art on 3D printing for meniscus reconstruction. Experiences in printing materials/technologies, scaffold types, augmentation strategies, cellular conditioning have been compared/discussed; outcomes of pre-clinical studies allowed for further considerations. To date, translation to clinic of 3D printed meniscal devices is still a challenge: meniscus reconstruction is once again clear expression of how the integration of different expertise (e.g., anatomy, engineering, biomaterials science, cell biology, and medicine) is required to successfully address native tissues complexities.
Diffuse large B-cell lymphoma with uncommon cardiac invasion
Authors: Daralammouri Yunis , Hamayel Hamza , Ismail Yahya , Majadla Sajed , Odeh Razan
Published: January 2022

Diffuse large B-cell lymphoma is the most common histologic subtype of non-Hodgkin lymphoma. Secondary involvement of the heart is seen late in advanced cases, it is uncommon for diffuse large B-cell lymphoma to present as intracardiac mass. A 26-year-old female patient presented with progressive shortness of breath, facial swelling, and lower limb edema. Imaging investigations by echocardiography and computed tomography showed a large right atrial mass that was obstructing the tricuspid valve. Open biopsy was taken, histopathology showed diffuse large B-cell lymphoma. She received six cycles R-CHOP chemotherapy (rituximab, cyclophosphamide, epirubicin, vincristine, and prednisone) with complete resolution of the mass. Diffuse large B-cell lymphoma can present with atypical and uncommon sites such as the heart as the first presentation. Early diagnosis and appropriate management is crucial given the poor outcome with late presentation. A high index of suspicion and the proper investigations is recommended to allow for early intervention and favorable outcomes as what happened with the case under discussion.
Metastatic breast cancer masquerading as a pituitary macroadenoma: A case report
Authors: Dedeker Connor , Archibald Hunter , Meares Annie , Mendez Alejandro , Hamlar David
Published: January 2022

The purpose of this manuscript is to report a case of symptomatic breast cancer metastasis to the pituitary gland, a described yet exceedingly rare phenomenon. A 52-year-old woman with a known history of stage-IV breast cancer treated 3 years prior with chemotherapy presented to the emergency department with 2 weeks of right-sided periorbital headache and 1 week of right-sided ptosis. Magnetic resonance imaging showed a 1.9 cm × 2.8 cm × 2.8 cm mass in the pituitary with mass effect on the right optic chiasm. Endocrine laboratory studies were largely normal, including prolactin, thyroid-stimulating hormone, insulin-like growth factor, and a minimally decreased cortisol. She underwent endoscopic transnasal transsphenoidal resection 4 days later to remove the mass without complication. Postoperative pathologic studies were positive for breast cancer metastasis, and she was subsequently started on adjuvant radiation and oral chemotherapy. While breast cancer metastases to the sella have been described in the literature before, symptomatic spread to the pituitary represents a small percentage of all breast cancer metastases, and we thus feel is worthy of further discussion.
Perceptions of China in Central Asia: Findings from an elite university in Bishkek
Authors: Primiano Christopher B , Rice Dana , Kudebayeva Alma
Published: January 2022

China's growing involvement in Central Asia economically, culturally, politically and even militarily has been a contentious topic for people from the region. While some view China's involvement as offering Central Asian countries an opportunity for advancement, others view it in more negative ways, with China having tremendous influence in the affairs of their country. In this article, we present our findings from a survey that we conducted at the American University of Central Asia in Bishkek, Kyrgyzstan. Our questions elicited responses that focus on perceptions of trade with China and China's actions regarding COVID-19, which are both polarizing issues in Kyrgyzstan and Central Asia overall.
Osteochondroma Arising From the Inferior Articular Process of the Lumbar Spine in a Geriatric Patient: A Case Report and Literature Review
Authors: Lin Guang-Xun , Wu Hua-Jian , Chen Chien-Min , Rui Gang , Hu Bao-Shan
Published: January 2022

Objective

Spinal osteochondromas are rare, and approximately less than 5% occur as spinal lesions. We report the case of a solitary osteochondroma of the spine and review and update the literature on spinal osteochondroma, including surgical treatment and subsequent results.

Case Description

A 73-year-old female patient complained of a 10-year history of back pain and a 4-year history of right-side lower extremity radiating pain with paresthesia. Computed tomography and magnetic resonance imaging (MRI) revealed a bony mass arising from the inferior articular process (IAP) of L3, presenting with features of compressive spinal stenosis at the L3–L4 level. The treatment strategy included the complete marginal excision of the lesion through the posterior approach, as well as complete decompression of the spinal canal and nerve roots. The patient’s symptoms resolved after surgery, and histopathological examination identified the lesion as an osteochondroma.

Review Results

This review study included 168 solitary osteochondroma cases. The most commonly involved spinal level was cervical (51.8%), and the most frequent spinal anatomic column involved was the posterior column (70.8%). Radiculopathy accounted for 30.3% of all cases, myelopathy accounted for 31.0%, and 7.7% exhibited both symptoms simultaneously. The recurrence rate was 6.0%.

Conclusion

Computed tomography and MRI can effectively diagnose spinal osteochondroma, and surgical treatment can effectively improve clinical outcomes. In almost all symptomatic cases, the best treatment is marginal excision of the tumor. Complete resection of the cartilaginous cap of the tumor is especially important to prevent recurrence.
SEAttle-based Research of Chinese Herbs for COVID-19 Study: A Whole Health Perspective on Chinese Herbal Medicine for Symptoms that may be Related to COVID-19
Authors: Taylor-Swanson Lisa , Altschuler Daniel , Taromina Katherine , Anderson Belinda , Bensky Daniel , Cohen Misha , Huang Helen , Ma Shouchun , Majd Iman , Mitchell Craig , Schnyer Rosa N , Conboy Lisa
Published: January 2022

Introduction

East Asian Medicine (EAM) is a Whole System medicine that includes Chinese herbal medicine (CHM). Chinese herbal medicine has been utilized to reduce symptom burden in infectious disease, with notable theoretical reformulations during pandemics of the 3rd, 13th, and 17th centuries. Today, Licensed Acupuncturists trained in CHM have utilized it to treat symptoms and sequelae of COVID-19. However, little is known about its use or efficacy by the public and health practitioners. Understanding and evaluating whole medicine systems of healthcare is inherently complex; there is international consensus for a descriptive, pragmatic approach. We are conducting a feasibility pilot study using a prospective, pragmatic, observational design using Whole Health and Whole Person perspectives. The complexity of COVID-19 reflects the impact on multiple homeoregulatory systems and provides a unique opportunity to assess the impact of interventions such as EAM on whole health. Observation of these EAM encounters will provide valuable qualitative and quantitative data on the interface of an extant Whole System medicine with a novel complex illness as a precursor to a randomized clinical trial.

Methods

This ongoing study observes a CHM clinic offering telehealth consultations to a diverse patient population since April, 2020. Patients who report symptoms potentially related to COVID-19 disease are consented for standardized collection and analysis of demographic and clinical data from each clinical encounter.

Results

To date, 61 patients engaged in 195 consultations (mean 3.3) with 49 reporting symptom resolution sufficient to complete treatment, and 4 withdrawals. Just over half (62%) were female, with an average age of 45.7 years. A wide variety of CHM formulas and EAM dietary and lifestyle modifications were provided.

Discussion

Adequate recruitment and retention suggest feasibility of the intervention and data collection. The rich dataset may facilitate the construction of Whole Health models of CHM’s clinical impact, as well as integrative inquiry into CHM’s effects on symptoms.
COVID-19 Vaccine Hesitancy and How to Address It
Authors: Rittle Chad
Published: January 2022

Background:

Although many Americans were anxious to see a vaccine developed to help restore a sense of normalcy to the COVID-19 pandemic, vaccine hesitancy is still a problem that hinders public health goals designed to stop the spread of the virus. With two mRNA vaccines available since early 2021 only 71% of Americans have received at least one dose of vaccine by November 30, 2021, with 60% of the population being fully vaccinated.

Methods:

This article discusses the risk factors of vaccine hesitancy, the factors influencing the unwillingness to accept vaccines approved and recognized as safe, characteristics of vaccine hesitancy among worker populations, and guidelines and resources for nurses.

Conclusions and Application to Practice:

The key for the nurse is to self-educate and proactively begin the discussion of vaccines with patients and co-workers, building trust with patients and peers, and helping motivate them to accept COVID-19 vaccines and make appointments to receive vaccinations. Overcoming the impact of low vaccination rates due to vaccine hesitancy is the first step toward closing the gap and achieving universal vaccination for all adults.
Elsberg Syndrome, Lumbosacral Radiculopathy, and Myelitis Due to Herpes Zoster in a Patient With Smoldering Myeloma
Authors: Desai Rohan , Welsh Cynthia T. , Schumann Samuel O.
Published: January 2022

Herpes zoster (HZ) is a common illness caused by the reactivation of latent varicella zoster virus (VZV) due to waning immunity, often secondary to old age or an underlying immunocompromised state. Its complications can manifest in variety of ways, including persistent neuralgias, vasculopathies, and stroke. Here, we describe a case of a 45-year-old man with a history of cryptogenic stroke and smoldering myeloma who was admitted with sacral HZ complicated by right lumbosacral radiculopathy and myelitis, otherwise known as Elsberg syndrome (ES). He was found to have an enhancing lesion in the peripheral conus medullaris on magnetic resonance imaging (MRI) with nonspecific inflammation and necrosis on biopsy pathology and cerebrospinal fluid (CSF) polymerase chain reaction (PCR) positive for VZV. The patient was initially treated with intravenous acyclovir and dexamethasone and discharged with a steroid taper and indefinite valacyclovir therapy. Twelve months postdischarge, the patient’s right lumbosacral radiculopathy and myelitis had almost completely resolved; however, he continued to require bladder self-catheterization. We believe that the patient’s underlying smoldering myeloma lead to an immunocompromised state, allowing for reactivation of latent VZV, resulting in both the patient’s cryptogenic stroke years earlier and recent ES.
Plasmablastic Lymphoma Presenting as Extensive Peritoneal and Retroperitoneal Nodules in an HIV-Positive Patient
Authors: Pokhrel Akriti , Yuldasheva Orzu , Mirashi Elidona , Nair Kiron , Salyana Muhammad , Jaswani Vijay , Avezbakiyev Boris , Wang Jen C.
Published: January 2022

Plasmablastic lymphoma (PBL) is a rare but aggressive subtype of diffuse large B-cell lymphoma (DLBCL). The diagnosis of PBL is challenging as its features overlap with lymphoma and myeloma. The most common presentation involves the oral cavity/jaw in human immunodeficiency virus (HIV)–positive patients. It has also been reported in the gastrointestinal (GI) tract, lymph nodes, and soft tissues. Usually, if PBL involves the GI tract, it presents as a gut tumor mass. In this report, we present an HIV-positive patient with PBL presenting with multiple peritoneal nodules. To our knowledge, this is the first case of PBL presenting as multiple peritoneal and retroperitoneal nodules in an HIV-positive patient. This case emphasizes the rare presentation of a rare malignancy, difficulties in establishing a diagnosis, and the importance of proper and timely management.
From a Machine Saw to a Case of Mycobacterium Fortuitum Pyomyositis
Authors: Sharifan Tejave , Idemudia Nosakhare , Sharma Rupam , Heidari Arash , Ragland Alan , Chao Tom , Fong Isabel
Published: January 2022

Pyomyositis is a bacterial infection occurring mainly in skeletal muscles. It is most commonly caused by Staphylococcus aureus with initial symptoms including muscle pain, swelling, and site tenderness. When available, the most accurate technique to determine the extent and the specific location of disease is the magnetic resonance imaging. Successful management includes early recognition, timely surgical debridement or drainage, and appropriate antibiotic therapy. This case report describes a case of Mycobacterium fortuitum pyomyositis in an elderly male associated with challenges of successful diagnosis.
Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial
Authors:   BEAR-MOON Design Group, Spindler Kurt P. , Imrey Peter B. , Yalcin Sercan , Beck Gerald J. , Calbrese Gary , Cox Charles L. , Fadale Paul D. , Farrow Lutul , Fitch Robert , Flanigan David , Fleming Braden C. , Hulstyn Michael J. , Jones Morgan H. , Kaeding Christopher , Katz Jeffrey N. , Kriz Peter , Magnussen Robert , McErlean Ellen , Melgaard Carrie , Owens Brett D. , Saluan Paul , Strnad Greg , Winalski Carl S. , Wright Rick
Published: January 2022

Background:

BEAR (bridge-enhanced anterior cruciate ligament [ACL] restoration), a paradigm-shifting technology to heal midsubstance ACL tears, has been demonstrated to be effective in a single-center 2:1 randomized controlled trial (RCT) versus hamstring ACL reconstruction. Widespread dissemination of BEAR into clinical practice should also be informed by a multicenter RCT to demonstrate exportability and compare efficacy with bone--patellar tendon–bone (BPTB) ACL reconstruction, another clinically standard treatment.

Purpose:

To present the design and initial preparation of a multicenter RCT of BEAR versus BPTB ACL reconstruction (the BEAR: Multicenter Orthopaedic Outcomes Network [BEAR-MOON] trial). Design and analytic issues in planning the complex BEAR-MOON trial, involving the US National Institute of Arthritis and Musculoskeletal and Skin Diseases, the US Food and Drug Administration, the BEAR implant manufacturer, a data and safety monitoring board, and institutional review boards, can usefully inform both clinicians on the trial’s strengths and limitations and future investigators on planning of complex orthopaedic studies.

Study Design:

Clinical trial.

Methods:

We describe the distinctive clinical, methodological, and operational challenges of comparing the innovative BEAR procedure with the well-established BPTB operation, and we outline the clinical motivation, experimental setting, study design, surgical challenges, rehabilitation, outcome measures, and planned analysis of the BEAR-MOON trial.

Results:

BEAR-MOON is a 6-center, 12-surgeon, 200-patient randomized, partially blinded, noninferiority RCT comparing BEAR with BPTB ACL reconstruction for treating first-time midsubstance ACL tears. Noninferiority of BEAR relative to BPTB will be claimed if the total score on the International Knee Documentation Committee (IKDC) subjective knee evaluation form and the knee arthrometer 30-lb (13.61-kg) side-to-side laxity difference are both within respective margins of 16 points for the IKDC and 2.5 mm for knee laxity.

Conclusion:

Major issues include patient selection, need for intraoperative randomization and treatment-specific postoperative physical therapy regimens (because of fundamental differences in surgical technique, initial stability construct, and healing), and choice of noninferiority margins for short-term efficacy outcomes of a novel intervention with evident short-term advantages and theoretical, but unverified, long-term benefits on other dimensions.
How Religious Discrimination is Perceived in the Workplace: Expanding the View
Authors: Schneider Rachel C. , Carroll Coleman Deidra , Howard Ecklund Elaine , Daniels Denise
Published: January 2022

Although religious discrimination in U.S. workplaces appears to be rising, little is known about how different groups of employees perceive discrimination. Here, the authors draw on 194 in-depth interviews with Muslim, Jewish, Christian, and nonreligious employees to examine perceptions of religious discrimination in the workplace. The authors identify several common modes of perceived discrimination, including verbal microaggressions and stereotyping, social exclusion and othering, and around religious holidays and symbols. The authors also find that Christians tend to link perceived discrimination to personal piety or taking a moral stand in the workplace, while Muslims, Jews, and nonreligious people tend to link discrimination to group-based stereotypes and describe a sense of being seen as religiously foreign or other. This study reveals the value of studying groups alongside one another for the fullest picture of workplace religious discrimination and points the way toward further sociological research of how both majority and minority groups perceive discrimination.
Ageing and selective inhibition of irrelevant information in an attention-demanding rapid serial visual presentation task
Authors: Walker Maegen E. , Vibell Jonas F. , Dewald Andrew D. , Sinnett Scott
Published: January 2022

Attention involves both an ability to selectively focus on relevant information and simultaneously ignore irrelevant information (i.e. inhibitory control). Many factors impact inhibitory control such as individual differences, relative timing of stimuli presentation, distractor characteristics, and participant age. Previous research with young adults responding to an attention-demanding rapid serial visual presentations of pictures superimposed with task-irrelevant words evaluated the extent to which unattended information may be subject to inhibitory control. Surprise recognition tests following the rapid serial visual presentation task showed that recognition for unattended words presented with non-targets (i.e. non-aligned or ‘NA’ words) during the rapid serial visual presentation task were recognised at chance levels. However, when the unattended words were infrequently paired with the attended picture targets (i.e. target-aligned or ‘TA’ words), recognition rates were significantly below chance and significantly lower compared to NA words, suggesting selective inhibitory control for the previously unattended TA words. The current study adapted this paradigm to compare healthy younger and older adults’ ability to engage in inhibitory control. In line with previous research, younger adults demonstrated selective inhibition with recognition rates for TA words significantly lower than NA words and chance, while NA words were recognised at chance levels. However, older adults showed no difference in recognition rates between word types (TA versus NA). Rather all items were recognised at rates significantly below chance suggesting inhibited recognition for all unattended words, regardless of when they were presented during the primary task. Finally, older adults recognised significantly fewer NA words compared to young adults. These findings suggest that older adults may experience a decline in their ability to selectively inhibit the processing of irrelevant information, while maintaining the capacity to exercise global inhibition over unattended lexical information.
Manufacturing mandates: Property, race, and the criminalisation of trespass in England and Wales
Authors: Burgum Samuel , Jones Helen , Powell Ryan
Published: January 2022

This paper focuses on a recent public consultation to criminalise trespass in England and Wales. Through an analysis of the consultation discourse and documentary evidence, we argue that the government has used this process to manufacture a mandate for criminalisation. We show how the construction of democratic support has been achieved by: Pre-coding responses in the initial call for evidence; distorting evidence in the response; and utilizing ‘state simplifications’ which foreground hostile and racist sentiments whilst presenting sedentarisation as in the ‘best interests’ of nomadic communities. While the 2018/19 consultation is only the most recent in a long history of civilising offensives against Gypsy-Travellers, as well as other ‘unfixed’ communities, this particular move to criminalise trespass and attack nomadic heritage is also further evidence of the UK government’s steady formalization of property ownership: moving away from considering property ‘use’ on the ground towards an abstracted registration system de-rooted from place. This denies long-standing rights to roam and non-normative modes of inhabitation, thereby pushing property relations in a direction that rarely benefits those on the housing margins. We foreground an alternative to criminalisation, pointing towards a recent pragmatic, bottom-up policy of ‘negotiated stopping’ in Leeds in northern England. This builds upon dialogue and cooperation in avoiding costly and disruptive eviction and criminalisation processes, but also potentially creates spaces and opportunities for more positive urban encounters with difference.
Quality of Life of Older People in Botswana
Authors: Mhaka-Mutepfa Magen , Wright Tshegofatso Caroline
Published: January 2022

This article discusses social determinants of health that influence quality of life (QOL) of older people in Botswana and suggests appropriate interventions. A cross-sectional study stratified by district was used to collect information on the elderly (N = 378). Data were collected from: demographics, individual factors (e.g., self-esteem), health-related factors (e.g., self-perceived health), clinical variables (e.g., social dysfunction), environmental assets (e.g., leisure) and the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF). The analyses showed that income earned, self-efficacy and self-esteem, access to health services, self-perceived health, and chronic disease condition were associated with QOL. Social dysfunction and environmental assets (leisure, secure and healthy physical environments) were also significantly associated with QOL

The results confirm that QOL is compromised by specific key factors. Thus, eradicating poverty, provision of services and a comfortable environment, promoting positive emotions (e.g., self-efficacy), and changing perceptions about self-rated health and self-rated QOL may enhance QOL among older people. The study has implications for policy, practice and further research.
The Modified Lemaire Procedure
Authors: Kittl Christoph , Wagner Michael , Weiler Andreas
Published: January 2022

Background:

Anterolateral rotatory instability (ALRI) may be one reasons why anterior cruciate ligament (ACL) reconstructions fail. An additional reconstruction of the anterolateral structures reduces the graft rupture rate by 50%. The modified Lemaire procedure is one of the lateral extra-articular tenodeses (LET) to restrain ALRI. The purpose of the present video is to describe this technique in detail.

Indications:

According to the international anterolateral complex consensus group indications may include revision ACL reconstruction, high grade pivot shift, generalized ligamentous laxity, like genu recurvatum, and young patients returning to pivoting activities. However, clinical evidence to recommend specific indications is still missing.

Technique description:

A 7 to 10 mm wide strip of the iliotibial tract, attached to Gerdy tubercle is shuttled deep to the lateral collateral ligament and is then attached proximal to the lateral femoral epicondyle. The biomechanical principle behind this is to place the graft posterior to the transverse axis of rotation through the entire range of motion. This posterior pull will restrain internal rotation and the anterior subluxation of the lateral tibial plateau.

Results:

Newer comparative studies show a reduced graft rupture rate and higher rate of returning to preinjury level, when adding an anterolateral extra-articular reconstruction to the ACL reconstruction at 2 years follow-up. At long-term follow-up there was also a trend toward decreased graft rupture rate. However, one must be aware of the possible increased risk of lateral compartment osteoarthritis.

Conclusion:

The modified Lemaire procedure is an easy-to-use addon to the ACL reconstruction, which can effectively reduce graft failure rate.
Awareness and Future Use of Open Educational Resources by Music Faculty
Authors: Allen Tanya
Published: January 2022

As teaching and learning experiences broaden to include more technological innovations, methods of instruction and resource flexibility are becoming increasingly important for educators and students. Open educational resources (OER) have gained international appeal for such flexibility, and post-secondary institutions are at the forefront of creating access to them. Although research related to OER has increased, few researchers have focused on OER in music instruction. In my cross-sectional survey of music faculty in the United States ( N = 409), I found that music faculty were generally unaware of OER although most participants would consider adopting an open textbook for a course. Motivating factors for adoption included ease of use and decreased costs for students, whereas time and financial support would be necessary for adoption to be feasible.
The Efficacy of ACR TI-RADS in the Management of Suspected Thyroid Nodules and Its Correlation With the Bethesda Scoring System
Authors: Karatay Emrah , Javadov Mirkhalig , Kartal Kinyas
Published: January 2022

Objective:

Ultrasonography (US) and fine-needle aspiration biopsy (FNAB) play an important role in the diagnosis of thyroid nodules. The primary aim of this study was to evaluate the relationship between American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) and the Bethesda system, based on final cytopathology.

Materials and Methods:

The cases that underwent thyroidectomy, due to a nodule, between May 2019 and May 2021 were retrospectively imaged. Of those cases, 73 patients were included in the study. The obtained data included ACR TI-RADS and the Bethesda system scores for nodules.

Results:

According to Spearman correlation, a very strong positive relationship was found between the Bethesda scoring system and ACR TI-RADS scores (ρ = 0.832, P < .0001). A 94.4% sensitivity and 65.4% specificity were found in 16 patients with a Bethesda score of 3 and TR3 based on final pathology ( P < .001). And a sensitivity of 77.3% and specificity of 51.5% were found in 17 patients, with a Bethesda score 4 and TR4 ( P < .001). Finally, a sensitivity of 55.6% and specificity of 50.0% were found in 17 patients with a Bethesda score 6 and TR5 ( P < .001).

Conclusion:

The routine use of the ACR TI-RADS classification in thyroid nodules could be useful in preventing unnecessary FNABs. It could be effective in minimizing complications secondary to FNAB and thyroidectomy and reducing costs.
A cognitively enhanced online Tai Ji Quan training intervention for community-dwelling older adults with mild cognitive impairment: A feasibility trial
Authors: Li Fuzhong , Harmer Peter , Fitzgerald Kathleen , Winters-Stone Kerri
Published: January 2022

Background

This study examines the feasibility, acceptability, and safety of a newly developed cognitive-enhancing Tai Ji Quan training intervention, delivered via remote videoconferencing, for older adults with mild cognitive impairment (MCI).

Methods

In a three-arm feasibility trial, community-dwelling older adults with MCI (N = 69; mean age = 74.6 years, 57% women) were randomized to a cognitively enhanced Tai Ji Quan (n = 23), standard Tai Ji Quan (n = 22), or stretching group (n = 24) and participated in a 60-minute online exercise session via Zoom, twice weekly for 16 weeks. Participants were recruited primarily in the state of Oregon through mass mailing and word of mouth. The primary outcomes were intervention feasibility (with respect to recruitment, online intervention delivery, fidelity and compliance, and attrition and retention rates), acceptability, and safety. We also assessed feasibility of online data collection and test-retest reliability and explored preliminary trends on secondary outcomes that included global cognitive function, dual-task cost, and domain-specific cognition function.

Results

The study had an average recruitment rate of 55%. Feasibility was demonstrated by the overall successful online program implementation, with good fidelity, acceptable compliance (76%), and excellent retention (94%). The cognitively enhanced Tai Ji Quan intervention was shown to be acceptable to participants as well as safe, with no major intervention-related moderate/severe events. At week 16, the group receiving cognitively enhanced Tai Ji Quan training showed a positive trend in the cognitive function and dual-task outcome measures whereas the group receiving standard Tai Ji Quan training exhibited positive trends on global and domain-specific cognitive measures.

Conclusions

Preliminary findings of this pilot study indicate the feasibility, acceptability, and safety of a tailored, cognitively enhanced Tai Ji Quan training intervention delivered remotely to home settings via videoconferencing for community-dwelling older adults with MCI.

Trial registration

Clinicaltrials.gov identifier NCT04070703
Types of household headship and associated life satisfaction among older adults in India: findings from LASI survey, 2017–18
Authors: Srivastava Shobhit , Muhammad T. , Sulaiman K. M. , Kumar Manish , Singh S. K.
Published: January 2022

Background

Household headship with decision-making power may have a positive influence on life satisfaction in older adults. This study examines the associations of several types of household headship with life satisfaction among older adults in India.

Method

The study utilized the data from the Longitudinal Ageing Study in India (2017–18). The effective sample size for the study was 31,464 adults aged 60 years or older. Ordered logistic regression model was employed to find the association of life satisfaction with household headship status after adjusting for selected socioeconomic and demographic factors.

Results

It was found that about 1.3% of older male and 1.5% of older females had nominal headship status in their household. Higher percentage of older males (42%) and females (48.3%) who had nominal headship status had low life satisfaction. In multivariable analysis, older adults who practiced nominal headship had significantly higher odds of low life satisfaction in reference to older adults who practiced functional headship [Adjusted odds ratio (AOR): 1.87; confidence interval (CI): 1.45,2.42]. Interaction model reveals that older men who practised nominal headship had significantly higher odds of low life satisfaction in reference to older men who practised functional headship [AOR: 2.34; CI: 1.59,3.45]. Similarly, older women who practised nominal headship had 55% significantly higher likelihood to have low life satisfaction in reference to older men who practised functional headship [AOR: 1.55; CI: 1.09, 2.18].

Conclusion

The recognition of older individuals as active agents of the households they belong to, and giving them the value they deserve may help boosting their mental well-being. As a direct driver of subjective well-being, headship status and decision making power deserve a more prominent role and future studies are required on the mechanisms of functional and nominal headship statuses that have impact on successful aging.
Lympho-vascular invasion impacts the prognosis in breast-conserving surgery: a systematic review and meta-analysis
Authors: Zhong Yi-Ming , Tong Fei , Shen Jun
Published: January 2022

Background

It is estimated that breast cancer (BC) incidence, especially that of early-stage breast cancer cases continues to rise due to increased universal screening. Breast-conserving surgery (BCS) is the main intervention for early-stage BC. Lympho-vascular invasion (LVI) is reported to influence breast cancer prognosis but its prognostic value in breast-conserving treatment is controversial.

Methods

A search was conducted on the Cochrane library, PubMed, Web of Science, and EMBASE from inception to December 1st, 2021, without language restrictions, to identify studies that explored the prognosis of lympho-vascular invasion in breast-conserving surgery. Reviews of each study were conducted, and data extracted. The meta-analysis was performed with StataSE 16. Study quality assessment was evaluated using the Newcastle–Ottawa Scale.

Results

Overall, 15 studies with 21,704 patients deemed eligible for this study. Event-free survival (EFS), disease-free survival (DFS), overall survival (OS), distant metastases (DM), loco-regional recurrence (LRR), local recurrence (LR), breast recurrence (BR), disease specific survival (DSS), and breast cancer specific survival (BCSS), were extracted from each study. We found that LVI leads to poor OS (HR = 1.46, 95% CI: 1.17–1.83), DM (HR = 2.08, 95% CI: 1.66–2.60) and LR (HR = 2.00, 95% CI: 1.54–2.61).

Conclusions

We confirmed that early-stage BC patients with LVI-positive have poorer OS, DFS, LRR, BCSS, DM and LR following receiving BCS than those LVI-negative patients. Mastectomy, in combination with radical systemic therapies could be considered, especially in those requiring second surgery. How to change the impact of LVI on the local recurrence rate and long-term survival in patients who undergo BCS may be a valuable research direction in the future.