bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Key Molecules in Recurrent Miscarriage Based on
Bioinformatics Analysis
Authors: Luo Songping , Gao Jie , Wu Haiwang , Ning Yan , Yu Qingying
Published: August 2021

Background:

Recurrent Miscarriage (RM) affects 1% to 5% of couples, and the
mechanisms still stay unclear. In this study, we explored the underlying molecular mechanism and
potential molecular biomarkers of RM as well as constructed a miRNA-mRNA regulation network.

Methods:

The microarray datasets GSE73025 and GSE22490, which represent mRNA and miRNA
profiles, respectively, were downloaded from the Gene Expression Omnibus (GEO) database.
Differentially Expressed Genes (DEGs) with p-value < 0.05 and fold-change > 2 were identified
while the miRNAs with p-value < 0.05 and fold-change > 1.3 were considered as significant
differentially expressed miRNAs (DEMs).

Results:

A total of 373 DEGs, including 218 up-regulated genes and 155 down-regulated genes,
were identified, while 138 up-regulated and 68 down-regulated DEMs were screened out. After
functional enrichment analysis, we found GO Biological Process (BP) terms significantly enriched
in the Fc-gamma receptor signaling pathway involved in phagocytosis. Moreover, signaling
pathway analyses indicated that the neurotrophin signaling pathway (hsa04722) was the top KEGG
enrichment. 6 hub genes (FPR1, C5AR1, CCR1, ADCY7, CXCR2, NPY) were screened out to
construct a complex regulation network in RM because they had the highest degree of affecting the
network. Besides, we constructed miRNA-mRNA network between DEMs target genes and DEGs
in RM, including hsa-miR-1297- KLHL24 and hsa-miR-548a-5p-KLHL24 pairs.

Conclusions:

In conclusion, the novel differentially expressed molecules in the present study could
provide a new sight to explore the pathogenesis of RM as well as potential biomarkers and
therapeutic targets for RM diagnosis and treatment.
Targeting Triglyceride Metabolism for Colorectal Cancer Prevention and
Therapy
Authors: Yarla Nagendra , Madka Venkateshwar , Rao Chinthalapally
Published: August 2021

Background:

Triglycerides (TG) are one of the major constituents of body fat and energy
reservoir, which consist of an ester derived from glycerol and three free fatty acids. TG lipase,
monoacylglycerol lipase, fatty acid synthase, and HMG-CoA reductase are some of the key enzymes
related to TG metabolism, and their roles in colorectal cancer (CRC) initiation and progression
are under investigation.

Methods:

The literature search was performed based on various published papers, mostly on triglyceride
metabolism relevant to CRC in PubMed, Google Scholar and other search engines. The
gene expression profiling of some of the TG metabolic pathway mediators was performed by transcriptomic
and/or proteomic data from The Cancer Genome Atlas (TCGA) database using R program
and cBioportal software.

Results and Discussion:

Accumulating pieces of evidence suggest that TG profiling may be used
as a biomarker for the diagnosis and/or prognosis of CRC. Dysregulation of TG metabolism is associated
with the initiation and progression of CRC. Most of the TG anabolic pathway mediators are
overexpressed and/or overactivated during CRC tumorigenesis, while most TG catabolic pathway
mediators are downregulated and/or inactivated based on literature search and correlated with TCGA
data. Metabolic enzymes of TG and FAs metabolic pathways are involved in CRC tumor
growth survival and metastasis.

Conclusion:

Overall studies from the previous literature and our TCGA data analysis demonstrated
that the area of research on TG-associated lipid metabolic pathways holds great promise and
warranted detailed investigations in this area for the implementation of novel preventive and therapeutic
strategies against CRC.
Engineering Metal-Organic Framework-based Nanozymes for Enhanced
Biosensing
Authors: Xu Weiqing , Wu Yu , Jiao Lei , Gu Wenling , Du Dan , Lin Yuehe , Zhu Chengzhou
Published: August 2021

Background:

Nanozymes are a kind of emerging nanomaterials that can mimic the catalytic
activity of natural enzymes with good stability.

Objective:

Benefited by the unique coordination structure and constitution, metal-organic frameworks
(MOFs) have been widely exploited as novel nanozymes. Importantly, various MOFs engineered
with fascinating functions provide great opportunities to enhance their enzyme-like activity
and improve their applied performance, achieving the goal of vividly mimicking natural enzymes.

Conclusion:

This review summarized recent advances in the fabrication of the MOFs-based
nanozymes and their applications in biosensing. First, MOFs-based nanomaterials containing pristine
MOFs, functionalized MOFs, MOFs-based composites and MOFs derivatives are introduced,
where the design strategy, enzyme-like activity and the catalytic mechanisms are highlighted systematically.
Then, their applications in various target assays are summarized. Finally, the challenges
and possible research directions for the development and application of MOFs-based
nanozymes are provided.
Analiysis of Phytoplankton Diversity on the Productivity of Vannamei Shrimp (Litopenaeus vannamei) Intensive Pond, Jatisari Village, Banyuwangi
Authors:   Universitas Brawijaya, Juliyanto Nabilla Anggi , Maftuch Maftuch , Masithah Endang Dewi ,   Universitas Airlangga
Published: August 2021

Phytoplankton can be used to estimate the potential for vannamei shrimp production. It can be used as a provider of nutrient sources and has an important role in improving water quality. This study aims to analyze the phytoplankton community structure on the productivity of intensive vannamei shrimp ponds. The research was conducted in Jatisari Village, Banyuwangi, East Java, Indonesia. Carried out parameters were the calculation of density, phytoplankton diversity index, culture performance (SR, FCR, ADG), and water quality (temperature, water transparency, salinity, pH, DO, NO2, NO3, PO4, NH4). The results showed that there were six classes and 33 genera from both ponds, Chlorophyceae (10 genera), Bacillariophyceae (8 genera), Cyanophyceae (9 genera), Dinophyceae (3 genera), Euglonophyceae (1 genus), Criptophyceae (1 genus). The index value of the two ponds shows moderate diversity, H 'pond 1 is 1.76, and pond 2 is 2.02. The two plots' cultivation performance was SR 92% and 80%, FCR 1.08 and 1.13, ADG 0.31 g.day-1 and 0.35 g.day-1, respectively. The physical and chemical parameters of the research showed a good enough value for the life of vannamei shrimp and phytoplankton. Keywords: Cultivation performance, Phytoplankton, Vannamei shrimp.
Perencanaan Sistem Pemanenan Air Hujan sebagai Alternatif Penyediaan Air Bersih Gedung Asrama TB 4 ITERA
Authors:   Institut Teknologi Sumatera, Fajar Mutiara , Ayatri Ranisa ,   Institut Teknologi Sumatera, Zurfi Alfian ,   Institut Teknologi Sumatera
Published: August 2021

Gedung asrama Institut Teknologi Sumatera (ITERA) memanfaatkan air tanah dalam memenuhi kebutuhan air bersih penghuninya, namun kuantitas air tanah pada asrama TB 4 ini tidak cukup untuk memenuhi kebutuhan air bersih, sehingga dibutuhkan transfer air dari asrama lain. Untuk itu diterapkan Pemanenan Air Hujan (PAH) sebagai alternatif penyediaan air bersih dan sebagai upaya dalam memanfaatkan air hujan. Air hujan yang dapat ditampung dipengaruhi oleh curah hujan harian maksimum menggunakan analisis hidrologi. Metode analisis hidrologi ini bertujuan untuk menganalisis kuantitas air hujan yang dapat tertampung melalui atap Asrama TB 4 ITERA. Data curah hujan yang dipakai pada perencanaan ini yaitu data dari BMKG Radin Inten Lampung Selatan. Untuk mendapatkan curah hujan dihitung menggunakan distribusi terpilih yaitu log pearson tipe III dan intensitas hujan menggunakan metode mononobe dengan PUH 5 tahun selama 2 jam sebesar 24.78 mm.hari-1. Dari curah hujan tersebut didapatkan dimensi talang, pipa tegak, pipa datar, dan pipa pencucian atap berukuran 5 inci. Sedangkan volume air hujan yang dapat tertampung sebanyak 10.100 liter per harinya. Perencanaan pemanenan air hujan di asrama TB 4 ITERA ini memerlukan biaya sebesar Rp. 65,532,800.00.
Distant Supervision for Mental Health Management in Social Media: Suicide Risk Classification System Development Study
Authors: Fu Guanghui , Song Changwei , Li Jianqiang , Ma Yue , Chen Pan , Wang Ruiqian , Yang Bing Xiang , Huang Zhisheng
Published: August 2021

Background

Web-based social media provides common people with a platform to express their emotions conveniently and anonymously. There have been nearly 2 million messages in a particular Chinese social media data source, and several thousands more are generated each day. Therefore, it has become impossible to analyze these messages manually. However, these messages have been identified as an important data source for the prevention of suicide related to depression disorder.

Objective

We proposed in this paper a distant supervision approach to developing a system that can automatically identify textual comments that are indicative of a high suicide risk.

Methods

To avoid expensive manual data annotations, we used a knowledge graph method to produce approximate annotations for distant supervision, which provided a basis for a deep learning architecture that was built and refined by interactions with psychology experts. There were three annotation levels, as follows: free annotations (zero cost), easy annotations (by psychology students), and hard annotations (by psychology experts).

Results

Our system was evaluated accordingly and showed that its performance at each level was promising. By combining our system with several important psychology features from user blogs, we obtained a precision of 80.75%, a recall of 75.41%, and an F1 score of 77.98% for the hardest test data.

Conclusions

In this paper, we proposed a distant supervision approach to develop an automatic system that can classify high and low suicide risk based on social media comments. The model can therefore provide volunteers with early warnings to prevent social media users from committing suicide.
Conducting Digital Health Care Research: Document Analysis of Challenges Experienced During Intervention Development and Feasibility Study Setup of an Internet-Administered Intervention for Parents of Children Treated for Cancer
Authors: Woodford Joanne , Karlsson Mathilda , Hagström Josefin , Hägg Sylvén Ylva , Norbäck Kajsa , Grönqvist Helena , von Essen Louise
Published: August 2021

Background

The design and conduct of research to develop, test, and evaluate complex health care interventions is challenging. Although the existing literature describes key challenges associated with the design and conduct of definitive (evaluation) trials, there is a lack of information concerning specific challenges associated with the intervention development phase and setup of feasibility studies. In particular, the literature is scarce concerning the challenges associated with conducting digital health care research, such as research on internet-administered interventions and research using digital features to support the execution of study procedures (eg, recruitment, consent, retention, and data collection and management). This study is conducted in the context of the intervention development and feasibility study setup phases of an internet-administered, guided, low-intensity cognitive behavioral therapy–based intervention for parents of children previously treated for cancer.

Objective

The aim of this study is to explore the challenges experienced during the development phase of the internet-administered intervention and digital features to support the execution of the study procedures and a feasibility study setup.

Methods

To explore the key challenges experienced, we conducted a document analysis of written records from all study meetings held by the research team (meeting minutes) between June 7, 2018, and January 10, 2020, guided by a thematic analysis approach. Furthermore, discussion groups with members of the research team were held to develop a more detailed understanding of the key challenges experienced. Methods and results are reported in accordance with the relevant items from the Standards for Reporting Qualitative Research checklist.

Results

Six main themes were identified: decision-making and communication, expertise, external constraints, flexibility, planning and scheduling, and technical constraints.

Conclusions

Significant challenges were experienced during the intervention development and setup phases of the feasibility study. Implications are discussed to inform future design, conduct, and planning of internet-administered intervention development and feasibility studies, especially within the context of digital health care research.
Questioning the Yelp Effect: Mixed Methods Analysis of Web-Based Reviews of Urgent Cares
Authors: Hu Dian , Liu Cindy Meng-Hsin , Hamdy Rana , Cziner Michael , Fung Melody , Dobbs Samuel , Rogers Laura , Turner Monique Mitchell , Broniatowski David André
Published: August 2021

Background

Providers of on-demand care, such as those in urgent care centers, may prescribe antibiotics unnecessarily because they fear receiving negative reviews on web-based platforms from unsatisfied patients—the so-called Yelp effect. This effect is hypothesized to be a significant driver of inappropriate antibiotic prescribing, which exacerbates antibiotic resistance.

Objective

In this study, we aimed to determine the frequency with which patients left negative reviews on web-based platforms after they expected to receive antibiotics in an urgent care setting but did not.

Methods

We obtained a list of 8662 urgent care facilities from the Yelp application programming interface. By using this list, we automatically collected 481,825 web-based reviews from Google Maps between January 21 and February 10, 2019. We used machine learning algorithms to summarize the contents of these reviews. Additionally, 200 randomly sampled reviews were analyzed by 4 annotators to verify the types of messages present and whether they were consistent with the Yelp effect.

Results

We collected 481,825 reviews, of which 1696 (95% CI 1240-2152) exhibited the Yelp effect. Negative reviews primarily identified operations issues regarding wait times, rude staff, billing, and communication.

Conclusions

Urgent care patients rarely express expectations for antibiotics in negative web-based reviews. Thus, our findings do not support an association between a lack of antibiotic prescriptions and negative web-based reviews. Rather, patients’ dissatisfaction with urgent care was most strongly linked to operations issues that were not related to the clinical management plan.
Peer Review of “Risk Factors of SARS-CoV-2 Infection: Global Epidemiological Study” (Preprint)
Authors:   Anonymous
Published: August 2021

UNSTRUCTURED

This is a peer review report.
Peer Review of “Risk Factors of SARS-CoV-2 Infection: Global Epidemiological Study” (Preprint)
Authors: Banik Palash
Published: August 2021

UNSTRUCTURED

This is a peer review report.
Neural Machine Translation Using Sequence Modeling
Authors: Revathi N
Published: August 2021

Abstract: Language is a main mode of communication, and translation is a critical tool for understanding information in a foreign language. Without the help of human translators, machine translation allows users to absorb unfamiliar linguistic material. The main goal of this project is to create a practical language translation from English to Hindi. Given its relevance and potential in the English-Hindi translation, machine translation is an efficient way to turn content into a new language without employing people. Among all available translation machines, Neural Machine Translation (NMT) is one of the most efficient ways. So, in this case, we're employing Sequence to Sequence Modeling, which includes the Recurrent Neural Network (RNN), Long and Short Term Memory (LSTM), and Encoder-Decoder methods. Deep Neural Network (DNN) comprehension and principles of deep learning, i.e. machine translation, are disclosed in the field of Natural Language Processing (NLP). In machine reclining techniques, DNN plays a crucial role. Keywords: Sequence to Sequence, Encoder-Decoder, Recurrent Neural Network, Long & Short term Memory, Deep Neural Network.
Minimum Voltage Vector Error Based Direct Torque Control for Induction Motors
Authors: Bihade Hrushikesh V.
Published: August 2021

Abstract: Traditional DTC popular because of its simplicity, Robustness, and first torque response. However, it is associated by high THD, large torque ripples and variable switching frequency. Which leads the way to scope of research in traditional DTC drive. thus, to further raise the performance, a method based on minimum voltage vector error is proposed in this dissertation. To cut down the error value between voltage vector imposed on the machine terminal and reference voltage vector, the value of Duty ratio is effectively optimized by propose method. The Optimization process does not increase the complexity of method. The proposed method is simulated in MATLAB environment. Keywords: TDTC, MVE DTC, Torque ripples, voltage-vector, current THD
Effect of salicylic acid and progesterone on physiological characteristics of Kentucky bluegrass under salinity stress
Authors: Sabzmeydani Elham , Sedaghathoor Shahram , Hashemabadi Davood
Published: August 2021

Salinity is one of the most important limiting factors in plant growth. It is also a predominant constraint that impairs grass growth and quality. Plant hormones play important roles in the capability of plants to adapt to environmental stresses. Hence, the impact of two plant growth regulators (PGRs) i.e. salicylic acid (SA) and progesterone (P4) was studied on biological characteristics of Poa pratensis in saline conditions in a greenhouse experimnt. The experimental treatments were composed of salinity at four levels (0, 2, 4, and 6 dS m-1) and six levels of PGRs (control, 1 mg L-1 P4,10 mg L-1 P4, 1 mM SA, 3 mM SA, and 1 mg L-1 P4 + 1 mM SA). The results showed that leaf firing percentage was increased with the excess in salinity, but the use of SA and P4 eased the effects of salinity stress and reduced leaf firing under salinity. 6 dS m-1 and 3 mM SA salinity caused to the maximum electrolyte leakage. The highest relative water content was observed in 4 dS m-1 salinity and 1 mM SA treatment. The highest glycine betaine was related to 6 dS m-1 NaCl and no hormone application. Salinity increased total protein and catalase, and the simultaneous use of P4 and SA exhibited the highest total protein and catalase content, whilst the control plants showed the lowest ones. The application of salinity stress reduced chlorophyll content, but SA and P4 increased it. The application of the two growth regulators improved carotenoid content under salinity stress. Overall, the results showed that the application of SA and P4 improved salinity tolerance and increased pigments and antioxidant enzyme activities.
Nutritional, antinutritional and phenological characterization of promising forage species for animal feeding in a cold tropical zone
Authors: Ramos Lesvy , Apráez José Edmundo , Cortes Kris Stephany , Apráez José Julián
Published: August 2021

The search for forages with high biomass production and high nutritional content has made it possible to find food alternatives that, due to their nutritional benefits and resistance to adverse environmental factors, are the best option for herbivores. With the knowledge of farmers, producers and the experience of researchers, 12 species most frequently used in animal feeding were selected, identified and classified in the University's PSO herbarium of the University of Nariño. These were phenologically, nutritionally and antinutritionally characterized. Of these species, four belonged to the Asteraceae family; the Fabaceae, Adoxaceae and Malvaceae families were represented by two species; the Salicaceae and Cucurbitaceae families were represented by one and were propagated in nursery. In the nutritional composition, the Retamo (Genista monspessulana) stood out for its high dry matter content with 34.2%. Unlike the Chauchilla (Cyclanthera brachystachya), with 8.79%, the Sauco (Sambucus peruviana) had a higher content of protein 25.93%, followed by Abutilon (Abutilon pictum) with 23.42%. Chauchilla (Cyclanthera brachystachya) had the highest crude fiber content, with 21.59%, NDF of 38.06%, and FDA 27.23%. Tannins were the most common secondary metabolites in the species evaluated with moderate or low levels; sterols were present at low levels, and saponins and alkaloids yielded negative values.
Inteligencia Artificial en empresas peruanas e impactos laborales en los trabajadores
Authors: Armas Morales Carlos
Published: August 2021

En algunas empresas peruanas, se observan gestas de transformación tecnológica, digitalización y automatización inherente al uso de la Inteligencia Artificial. En tal sentido, el artículo explora y describe, desde un enfoque cualitativo la utilización de la inteligencia artificial en Perú y el posible impacto en los trabajadores por la gestación de nuevos puestos y desaparición de otros debido al uso de estas tecnologías. La investigación tuvo el enfoque cualitativo, utilizo la técnica documentaria, entrevistas, encuesta y la técnica de comparación normativa. Los resultados indican que el uso de la inteligencia artificial en el Perú por las empresas es incipiente, pero se intensificara en los próximos años. De otro lado la normativa laboral del Estado relacionado con estas innovaciones, se encuentra desfasada, de tal manera que las empresas que opten por el despido de los trabajadores excedentes o que no se adecúen a los nuevos puestos, tendrán dificultades, pues la normativa laboral no está actualizada a la nueva realidad que medie el derecho de los empresarios a innovar (IA) y el derecho de las personas de trabajar.
Reclamos y satisfacción del sector empresarial respecto al servicio eléctrico en la zona sur del Perú
Authors: Fernandez Argandoña Regis Andre Junior
Published: August 2021

El presente artículo tiene como principal objetivo determinar la relación que existe entre la aplicación del procedimiento de atención de reclamos en el servicio de electricidad y la satisfacción desde la perspectiva del empresario tacneño, en el año 2019. El tipo de investigación fue no experimental de nivel correlacional. La encuesta fue la técnica de recolección de datos mientras que el instrumento fue el cuestionario. Teniendo una población de 203 empresarios y aplicando el instrumento a 133 como muestra representativa. Después de aplicar los respectivos instrumentos se obtuvo como resultado que existe correlación significativa entre la variable aplicación del procedimiento de atención de reclamos en el servicio de electricidad y la variable satisfacción desde la perspectiva del empresario tacneño, 2019. Asimismo, se encontró un coeficiente de correlación estadísticamente significativo positivo perfecto (P=0,973), por lo que se concluye que existe una relación entre la aplicación del procedimiento de atención de reclamos del servicio de electricidad y la satisfacción de los empresarios tacneños.
Point-of-care ultrasound in a multiplace hyperbaric chamber
Authors:   Undersea and Hyperbaric Medicine Division, Department of Emergency Medicine, Keck School of Medicine of USC, Los Angeles, California U.S., Hornbeak Kirsten , Duchnick Jay ,   Hyperbaric Medicine Division, Department of Emergency Medicine, University of California San Diego, San Diego, California U.S., Medak Anthony ,   Hyperbaric Medicine Division, Department of Emergency Medicine, University of California San Diego, San Diego, California U.S., Lindholm Peter ,   Hyperbaric Medicine Division, Department of Emergency Medicine, University of California San Diego, San Diego, California U.S., Tanaka Hideaki L. ,   Hyperbaric Medicine Division, Department of Emergency Medicine, University of California San Diego, San Diego, California U.S.
Published: August 2021

Historically, electronic devices have been generally prohibited during hyperbaric oxygen (HBO2) therapy due to risk of fire in a pressurized, oxygen-rich environment. Point-of-care ultrasound (POCUS), however, has emerged as a useful imaging modality in diverse clinical settings. Hyperbaric chambers treating critically ill patients would benefit from the application of POCUS at pressure to make real-time patient assessments. Thus far, POCUS during HBO2 therapy has been limited due to required equipment modifications to meet safety standards. Here we demonstrate proof of concept, safety, and successful performance of an off-the-shelf handheld POCUS system (SonoSite iViz) in a clinical hyperbaric environment without need for modification.
Changes in acid-base status in oxygen toxicity at 230 kPa oxygen as a function of exposure time
Authors:   Department of Diving and Hyperbaric Medicine, Naval Medical Center, Shanghai, China, Bao Xiao-Chen , Chen Hong ,   Cadre Diagnosis and Treatment Department, The General Hospital of the People’s Liberation Army, Beijing, China, Fang Yi-Qun ,   Department of Diving and Hyperbaric Medicine, Naval Medical Center, Shanghai, China, Wang Nang ,   Department of Diving and Hyperbaric Medicine, Naval Medical Center, Shanghai, China, Wang Fang-Fang ,   Department of Diving and Hyperbaric Medicine, Naval Medical Center, Shanghai, China
Published: August 2021

Breathing less than 50 kPa of oxygen over time can lead to pulmonary oxygen toxicity (POT). Vital capacity (VC) as the sole parameter for POT has its limitations. In this study we try to find out the changes of acid-base status in a POT rat model. Fifty male rats were randomly divided into five groups, exposed to 230 kPa oxygen for three, six, nine and 12 hours, respectively. Rats exposed to air were used as controls. After exposure the mortality and behavior of rats were observed. Arterial blood samples were collected for acid-base status detection and wet-dry (W/D) ratios of lung tissues were tested. Results showed that the acid-base status in rats exposed to 230 kPa oxygen presented a dynamic change. The primary status was in the compensatory period when primary respiratory acidosis was mixed with compensated metabolic alkalosis. Then the status changed to decompensated alkalosis and developed to decompensated acidosis in the end. pH, PCO2, HCO3-, TCO2, and BE values had two phases: an increase and a later decrease with increasing oxygen exposure time, while PaO2 and lung W/D ratio showed continuously increasing trends with the extension of oxygen exposure time. Lung W/D ratio was significantly associated with PaO2 (r = 0.6385, p = 0.002), while other parameters did not show a significant correlation. It is concluded that acid-base status in POT rats presents a dynamic change: in the compensatory period first, then turns to decompensated alkalosis and ends up with decompensated acidosis status. Blood gas analysis is a useful method to monitor the development of POT.
Hyperbaric oxygen therapy and fluorescence angiography in arterial insufficiency secondary to injection of crushed hydromorphone
Authors:   Department of Hyperbaric Medicine, Louisiana State University, New Orleans, Louisiana U.S., Ray Kristi , Savaser Davut ,   Hyperbaric Medicine and Chronic Wound Clinic, Legacy Emanuel Medical Center, Portland, Oregon U.S., Huang Enoch ,   Hyperbaric Medicine and Chronic Wound Clinic, Legacy Emanuel Medical Center, Portland, Oregon U.S.
Published: August 2021

Introduction: Foreign body emboli can lead to acute arterial insufficiency. We present a case report of upper extremity arterial insufficiency in an intravenous (IV) drug user secondary to intra-arterial injection of crushed tablet particles successfully treated with hyperbaric oxygen (HBO2) therapy. Case: A 37-year-old right-hand-dominant male developed pain and swelling of the left hand after attempting to inject crushed hydromorphone tablets into his venous circulation. Angiography revealed incomplete distal filling of the proper digital arteries, princeps pollicis, and radialis indicis branches of the left hand. The patient was treated with HBO2 for acute arterial insufficiency, secondary to these findings. Fluorescence angiography was performed prior to, during and after completion of HBO2, which showed improved perfusion of the hand upon completion of serial imaging. The patient underwent subsequent partial amputation of the left second digit and removal of the thenar and third finger pads. Discussion: Much of the literature on treatment of arterial insufficiency with HBO2 are in relation to chronic problem wounds. However, there is limited data on adjunctive treatment with HBO2 for foreign body embolism. Fluorescence angiography and clinical exam were used to track tissue perfusion and progression throughout course of therapy with HBO2. Conclusion: Acute arterial insufficiency induced by foreign body embolism was successfully treated with HBO2 and provided increased tissue salvage of the patient’s hand. The use of fluorescence angiography as a secondary measure of perfusion can provide additional insight regarding qualitative tissue oxygenation and may be a viable tool to track patient progress during HBO2 treatment.
Submarine medicine: An overview of the unique challenges, medical concerns, and gaps
Authors: Beardslee Luke A. , Casper Erica T. , Lawson Ben D. ,   Naval Submarine Medical Research Laboratory, Submarine Base New London, Groton, Connecticut, U.S.
Published: August 2021

Submariners face many challenges. For example, they “live where they work” and can be called to duty anytime. They have limited access to open space, natural settings, fresh air, fresh food, sunlight, privacy, exercise, and outside communication. They support a wider range of missions than occur aboard most other Navy vessels. At sea or on shore, submariners work long hours under conditions with little margin for error. They may traverse remote or disputed areas of the ocean far from rescue assets, and must remain vigilant for potential encounters with hostile forces, onboard fires, anomalies in the breathing atmosphere, leaks, undersea collisions, or radiation exposures. If any of these factors cause casualties, the Independent Duty Corpsman (with intermittent advice from shore-based medical personnel), must be ready to provide aid as long as necessary. The challenges of submarine service led to the growth of the unique field of submarine medicine, which has maintained an excellent record of health and safety. This review introduces the field of submarine medicine as practiced in the U.S. Navy, describing its major concerns, giving an overview of the operation of a submarine medical department, and identifying several medical gaps that researchers are working to fill. Submarine medicine already has a stellar record in terms of radiation and atmospheric safety and has made strides in fatigue management. Ongoing work will deliver improved psychological screening and support tools. This report summarizes developments in these and other areas of submarine medicine.
Decrease in dysbaric osteonecrosis severity as a result of 45-minute oxygen pre-breathe
Authors:   Department of Pediatrics, Division of Critical Care, University of Wisconsin School of Medicine and Public Health Madison, Wisconsin U.S., Lamers Jacob ,   John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin U.S., MacLaughlin Kent ,   Department of Pediatrics, Division of Critical Care, University of Wisconsin School of Medicine and Public Health Madison, Wisconsin U.S.,   John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin U.S., Pegelow Dave ,   Department of Pediatrics, Division of Critical Care, University of Wisconsin School of Medicine and Public Health Madison, Wisconsin U.S.,   John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin U.S., Eldridge Marlowe ,   Department of Pediatrics, Division of Critical Care, University of Wisconsin School of Medicine and Public Health Madison, Wisconsin U.S.,   John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin U.S., Sobakin Aleksey ,   Department of Pediatrics, Division of Critical Care, University of Wisconsin School of Medicine and Public Health Madison, Wisconsin U.S.,   John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin U.S.
Published: August 2021

Sudden decompression can result in bubble formation as the result of nitrogen gas (N2) dissolved in tissue during disabled submarine escape (DISSUB). This may cause dysbaric osteonecrosis (DON), a condition in long bones where bubbles in fatty marrow result in ischemia and necrosis. Previous research has shown that oxygen (O2) pre-breathe of two hours resulted in a reduction of DON; however, effects of shorter O2 pre-breathe remain uncertain. This study’s aim was to understand the effect of shorter lengths of O2 pre-breathe. Eight adult Suffolk ewes (89.5± 11.5 kg) were exposed to 33 feet of seawater (fsw) for 24 hours. They were placed randomly into four groups and exposed to either 45, 30 or 15 minutes of O2 (91-88%) pre-breathe; the controls received none. They were then rapidly decompressed. Alizarin complexone was later injected intravenously to visualize the extent of DON in the right and left long bones (radii, tibiae, femur and humeri). The 30- and 15-minute pre-breathe groups saw the greatest deposition. There was significant decrease of variance in the 45-minute group when compared with all other treatments, suggesting that 45 minutes of O2 pre-breathe is required to effectively increase confidence in the reduction of DON. Similar confidence was not reflected in the 30-minute and 15-minute groups: 45 minutes of pre-breathe was the minimum amount needed to effectively prevent against DON in DISSUB escape at 33 fsw. However, future research is needed to determine how to calculate effective dosages of O2 pre-breathe to prevent DON in any given scenario.
Effects of hyperbaric oxygen pretreatment on brain antioxidant capacity in rats with decompression sickness
Authors:   Department of Aerospace Hygiene, School of Aerospace Medicine, Fourth Military Medical University, Xi’ an, Shaanxi Province, China, Li Ya , Xu Xiaona ,   Department of Health Education and Management, School of Preventive Medicine, Fourth Military Medical University, Xi’ an, Shaanxi Province, China, Bao Junxiang Bao ,   Department of Aerospace Hygiene, School of Aerospace Medicine, Fourth Military Medical University, Xi’ an, Shaanxi Province, China, Wang Wenlan ,   Department of Aerospace Hygiene, School of Aerospace Medicine, Fourth Military Medical University, Xi’ an, Shaanxi Province, China
Published: August 2021

Objective: Decompression sickness (DCS) causes serious brain hypoxic-ischemic injury. This experiment was designed to observe whether hyperbaric oxygen (HBO2) pretreatment played a neuroprotective effect in decompression sickness rat models and to explore the mechanism of protective effects. Methods: Sprague-Dawley (SD) male rats were pretreated with HBO2 and then underwent decompression to establish the DCS rat model. Antioxidant capacities were evaluated by detecting peroxides (GPx), superoxide dismutase (SOD), catalase (CAT) activity and malondialdehyde (MDA) content in brains. The levels of metal elements manganese (Mn), zinc (Zn), iron (Fe) and magnesium (Mg) in brain tissues were assessed by flame atomic absorption spectrometry. Necrosis and apoptosis of neurons were assessed by H-E staining and immunohistochemical staining. Results: HBO2 pretreatment reduced the degree of necrosis and apoptosis in brain tissues of decompression sickness rat models. In addition, HBO2 pretreatment increased GPx, SOD and CAT activities and reduced MDA accumulation. It also increased the content of Mn, Zn, Fe and Mg in brain tissue, which are all related to free radical metabolism. Conclusion: These results suggested that HBO2 pretreatment has protective effects on brain injury of rats with decompression sickness. The mechanism of the protective effects may be related to reducing oxidative damage by affecting metal elements in vivo.
As Ações de Informação e seus contextos: aportes da pragmática ao campo investigativo da Ciência da Informação
Authors: González de Gómez Maria Nélida
Published: August 2021

Estudos anteriores indicam que existem elos, implícitos e explícitos, entre as micro regras das ações informacionais, singulares, situadas, e as macro regras da economia, da administração, da política. Hoje, a expansão dos dispositivos e ambientes digitais, gera novas questões sobre as relações que se estabelecem entre ações locais e situadas, e ações informacionais de outra ordem e extensão, implementadas nos ambientes digitais. Neste trabalho, procura-se melhor entender o que constitui o contexto das ações de informação, e como ele se modifica (ou não), conforme se modificam as condições culturais e tecnológicas em que estão ancoradas. Recorremos para isso aos quadros conceituais das abordagens pragmáticas, e a estudos socioantropológicos que ilustram as mudanças na função, efeitos e relevância dos contextos das ações de informação.

Palavras-chave: Ações de informação. Contextos. Situações sintéticas.
Avaliação dos riscos de deslizamento no bairro de Sapucaia no município de Olinda, Pernambuco, Brasil
Authors: Gonçalves Lorena Maria da Silva , Silva Luciana Cássia Lima da , Lafayette Kalinny Patricia Vaz
Published: August 2021

A ocupação de áreas de risco é a maior característica desse desbalanceamento, resultando em aglomerados em áreas inapropriadas para construção, tornando o ambiente nocivo e vulnerável, tanto para a população quanto para o meio. Dessa forma, o presente trabalho tem como objetivo analisar os impactos gerados pela ocupação urbana numa área de risco no município de Olinda/PE. Através da visita de campo foi feita uma caracterização da área e dos pontos críticos no que diz respeito aos agentes contribuintes de áreas de risco. Por meio de mapas coletados em fontes externas foi feita uma análise quantitativa do uso do solo por meio do georreferenciamento de ortofotocartas dos anos de 1975 e 1986, e de imagens de satélite dos anos de 2009 e 2018, utilizando o software QGIS. Os resultados permitiram entender o impacto gerado pelo processo de ocupação da área, demostrando uma diminuição de 45% na cobertura vegetal da área, no total dos anos estudados, em função de um crescimento de 43% da área de mancha urbana, expondo assim as ações antrópicas efetivas que fomentam de forma direta no ambiente e os impactos que tornam o meio, que por si só já é vulnerável, em uma área de risco constante.
PERFORMANCE-RITUAL ÜHPÜ
Authors: Vieira Gonçalves Luiz Davi
Published: August 2021

Este artigo apresenta o processo de criação da performance-ritual Ühpü. Desenvolvida pelo grupo de pesquisa Tabihuni, na Universidade do Estado do Amazonas – UEA, teve como pilar a experiência simétrica entre indígenas e não indígenas no ritual xamânico conduzido pelos indígenas Bu’u Kennedy, da etnia Ye’pá mahsã (Tukano), e Chris TK, da etnia Huni Kuin (Kaxinawa). Neste sentido, o presente artigo descortina ao campo das Artes da Cena uma experiência decolonial construída simetricamente na imersão no xamanismo, fazendo com que, antes de qualquer “encenação”, encontrássemos nossa real existência, presença e, principalmente, nossa subjetividade no/para mundo.
REALISMO DE CONFRONTO, ATORES-MONSTROS E MONSTROS-ATORES
Authors: Guéron Rodrigo , Souza Amaral Marcela
Published: August 2021

Considerando a hipótese do conceito de “Realismo de Confronto”, oriundo da observação de filmes contemporâneos, buscamos trazer uma questão que não é exclusiva aos filmes de nossa época, a de um realismo que coloca em questão o próprio real. Ao analisarmos as relações e as tensões entre atores e não atores e personagens, situações reais e/ou fictícias, encontramos proximidade com a teoria de Deleuze sobre as relações entre o virtual e o atual no cinema e a afirmação do filósofo que “o ator é um monstro”. Analisando o filme Monstros (Freaks, Tod Browning, 1932) e relacionando-o a outros mais contemporâneos, articularemos o “realismo de confronto” às relações entre o atual e o virtual no corpo dos atores.
“BATUQUE NA COZINHA, SINHÁ NÃO QUER”
Authors: Neves de Oliveira Victor Hugo
Published: August 2021

Este artigo busca analisar o teatro preto como estratégia contemporânea de enfrentamento ao racismo, a partir de pressupostos políticos, estéticos e criativos. Propomos uma defesa do teatro preto como um movimento de transgressão e decolonização por meio de suas relações com a perspectiva da afrocentricidade.
Jardim Proibido: o Peso de Vender Pastel no Lugar Errado
Authors: Matos Júnior José Ednilson , Silva Marcio Roque dos Santos da , Olave Maria Elena Leon , Santana Felipe Borges de
Published: August 2021

Contexto: Este caso para ensino conta a trajetória de sucesso de um casal de empreendedores do ramo alimentício da cidade de Aracaju/Sergipe, permeando os desafios e as conquistas enfrentados nessa jornada. Trata-se de uma história real, contudo os diálogos foram simulados para ilustrar a sequência dos fatos. A análise se concentra na fase de expansão do negócio e suas consequências, evidenciando abordagens que permitem refletir a relevância: de ferramentas gerenciais, como o Plano de Negócios; do planejamento estratégico; e da tomada de decisão gerencial a partir do diagnóstico organizacional e ambiental. Objetivos de ensino: Espera-se que os alunos compreendam a importância do diagnóstico empresarial e ambiental, auxiliado por ferramentas de gestão, para a tomada de decisão, considerando ações estratégicas para solucionar problemas diagnosticados. Fontes de dados: Os dados foram produzidos por meio de entrevista semiestruturada, com o casal de empreendedores, e de fontes secundárias. Aplicação: O conteúdo é sugerido para cursos de graduação e pós-graduação em Administração, Gestão de Negócios, Gestão Empresarial e áreas afins, em disciplinas como: Empreendedorismo; Gestão de Negócios; Planejamento Estratégico; e Análise Financeira.
A Probabilidade de Negociações Informadas (PIN) versus Disclosure de Negociações dos Insiders: o Caso da JBS S.A. (JBSS3) com Modelos de High-Frequency Trading
Authors: Nóbrega Pordeus Glauco Graco , Pontes Girão Luiz Felipe de Araújo , Coelho de Lima Duarte Filipe
Published: August 2021

Objetivo: Este trabalho tem como objetivo principal identificar operações de compra ou venda no ativo JBSS3, da empresa JBS S.A., e introduzir uma metodologia de análise de operações com base na proxy de informação assimétrica captada pela métrica de Probabilidade de Negociações Informadas (PIN). Metodologia: A JBS S.A. é usada como caso de análise nesta pesquisa pois foi o 1º caso de prisão por insider trading no Brasil. Desta maneira, foram usados modelos matemáticos para a estimação da PIN para verificar se era possível se antecipar aos movimentos de uma pessoa com acesso a informações privilegiadas.  Principais resultados: Os resultados encontrados apontam que a) o relatório obrigatório e mensal exigido pelo órgão regulador do mercado de capitais é pouco útil para proteger o investidor brasileiro, b) que mesmo com um modelo matemático avançado, não foi possível (em partes) obter retorno anormal antecipando as operações dos insiders, mas c) o modelo matemático da PIN gerou melhores resultados do que o relatório exigido pelo regulador. Contribuições acadêmicas: Foi possível inserir mais uma contribuição com relação ao uso de ferramentas computacionais na literatura sobre o mercado financeiro, como meio de promoção e aprimoramento da eficiência de mercado. Contribuições práticas: Investidores poderão se beneficiar com o uso dos resultados desta pesquisa tanto para se protegerem da seleção adversa e do risco moral e o regulador do mercado de capitais poderá usar técnicas semelhantes para ampliar a fiscalização do mercado, além de ser mais um ponto de partida para a geração de modelos de high-frequency trading.
Enviromental DNA (eDNA) reveals potential for interoceanic fish invasions across the Panama Canal
Authors: Schreiber Lennart , Castellanos-Galindo Gustavo , Torchin Mark , Chavarria Karina , Laakmann Silke , Saltonstall Kristin
Published: August 2021

Interoceanic canals can facilitate biological invasions as they connect
the world’s oceans and dissolve dispersal barriers between bioregions.
As a consequence, multiple opportunities for biotic exchange arise and
the resulting establishment of migrant species often causes adverse
ecological and economic impacts. The Panama Canal is a key region for
biotic exchange as it connects the Pacific and Atlantic Oceans in
Central America. In this study, we used two complementary methods
(environmental DNA (eDNA) and gillnetting) to survey fish communities in
this unique waterway. Using COI (cytochrome oxidase subunit I)
metabarcoding, we detected a total of 142 taxa, including evidence for
the presence of sixteen Atlantic and eight Pacific marine fish inside
different sections of the Canal. Of these, ten are potentially new
records of marine taxa detected in the freshwater segment of the Canal.
Molecular data did not capture all species caught with gillnets, but
generally provided a more complete image of the fish fauna. Diversity
indices based on eDNA surveys revealed significant differences across
different sections of the Canal reflecting in part the prevailing
environmental conditions. The observed increase in the presence of
marine fish species in the Canal indicates a growing potential for
interoceanic exchange of fishes across the Isthmus. Monitoring using
eDNA is a rapid and efficient way to assess potential changes in the
fishes of this important waterway.
Factors Affecting Students’ Academic Achievement according to the Teachers’ Opinion
Authors: Ozcan Mehmet
Published: August 2021

The aim of this research is to reveal the ideas of teachers serving in high schools regarding the factors that affect students’ academic achievement. For this purpose, the aim is to investigate and reveal in depth the thoughts of teachers serving in high schools. The research was designed with the case study type of qualitative research method. The study group of this research consists of 11 female, 9 male branch teachers employed in high schools. The participants’ professional experience ranged from 1 to 13 years. The participant group consisted of 5 Turkish language and literature teachers, 5 mathematics teachers, 3 English teachers, 2 history teachers, 1 biology teacher, 1 information technology teacher, 1 chemistry teacher, 1 physics teacher and 1 physical education teacher. The study group was determined with the criterion sampling type of purposive sampling method. The criteria determined for this research were that teachers should be working in high schools, be branch teachers and be serving in schools in the province and district. According to the research findings family education level effects students’ academic success in terms of academic support, being a role model, concern, intellectual and motivation dimensions; school’s physical conditions effects students’ academic success in terms of learning, motivation and creativity; School Management effects students’ academic success in terms of operation and attitude. School Environment effects students’ academic success in terms of motivation, social effects and socio-economic effects. Teacher effects students’ academic success in terms professional competence, being a role model, communication, attitude, motivation and guidance.
Synthesis and properties of new fused pyrrolo-1,10-phenanthroline type derivatives
Authors: Al-Matarneh Cristina , Rosca Irina , Shova Sergiu , Danac Ramona
Published: August 2021

New fused pyrrolo-phenanthroline type derivatives were synthesized, in two steps, from 1,10-phenanthroline and evaluated for antimicrobial activity and fluorescence properties. Our synthetic approach involved a 3+2 dipolarcycloaddition of some selected N-substituted 1,10-phenanthrolin-1-ium ylides, (m)ethoxycarbonyl and cyano (1,2-di)substituted acetylenes and alkenes, respectively. The structures of compounds were supported by analytical and spectroscopic data. The molecular structures of four selected compounds have also been also determined by monocrystal XRD analyses. All synthesized compounds were then evaluated for their potential antimicrobial activity against Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922 and Candida albicans ATCC10231. Two of the compounds demonstrated significant activity against the above tested strains.