bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pemberian Edukasi Untuk Meningkatkan Pengetahuan Masyarakat Tentang Dagusibu (Dapatkan, Gunakan, Simpan, Buang) Obat Antibiotik di Desa Tangkahen Kalimantan Tengah
Authors: Febriani Carolina , Aryzki Saftia , Rohama Rohama , Safitri Rina
Published: July 2024

Antibiotik adalah obat yang digunakan untuk penyakit infeksi bakteri. Sekarang ini masyarakat dapat dengan mudah membeli dan mendapatkan obat antibiotik dengan bebas, sehingga sering kali masyarakat tidak tepat dalam penggunaan yang mengakibatkan keefektifan antibiotik berkurang. DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) adalah salah satu cara pengelolaan obat yang baik dan benar. Cara pengelolaan ini menjelaskan bagaimana mendapatkan obat, menggunakan obat, menyimpan obat, serta membuang obat. Pengetahuan DAGUSIBU ini dapat meningkatkan kualitas hidup masyarakat yang sering menggunakan obat-obatan antibiotik. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian edukasi untuk meningkatkan pengetahuan tentang DAGUSIBU obat antibiotik di Desa Tangkahen Kalimantan Tengah. Metode pada penelitian ini yaitu pre- eksperimental dengan rancangan one group pretest, post-test dilakukan menggunakan media leaflet yang dianalisis menggunakan analisis statistik regresi ordinal. Hasil penelitian pengetahuan DAGUSIBU antibiotik sebelum dan sesudah pemberian edukasi. Hasil analisis regresi ordinal didapatkan hasil nilai Sig (2-tailed) sebesar 0,000 yang artinya nilai tersebut di bawah 0,05 yang berarti terdapat perbedaan yang signifikan sebelum dan sesudah pemberian edukasi. Kesimpulan dari penelitian ini yaitu terdapat pengaruh pemberian edukasi terhadap pengetahuan DAGUSIBU antibiotik.
Aktivitas Antibakteri Sediaan Sirup Ekstrak Daun Sirih Merah (Piper crocotum Ruiz & Pav) Terhadap Bakteri Salmonella typhii
Authors: Damayanti Linda Meydigret , Mahdiyah Dede , Noval Noval , Nastiti Kunti
Published: July 2024

Demam tifoid merupakan penyakit menular yang tersebar di seluruh dunia dan sampai sekarang masih menjadi masalah kesehatan terbesar di negara berkembang dan tropis. Insiden penyakit ini masih sangat tinggi dengan lebih dari 700 kasus berakhir dengan kematian. Bakteri Salmonella typhii masuk melalui mulut ke dalam saluran pencernaan. Daun sirih merah (Piper crocatum) memiliki senyawa kimia yang bermanfaat antara lain alkaloid, saponin, tanin, dan flavonoid yang memiliki sifat antibakteri dan antiinflamasi. Uji aktivitas antibakteri banyak dilakukan langsung pada ekstrak tumbuhan, belum ada uji pada bentuk sediaan seperti larutan sirup. Sirup juga sediaan cair yang dapat digunakan oleh hampir semua usia, cepat diabsorpsi, sehingga cepat menimbulkan efek. Tujuan penelitian ini untuk menguji aktivitas dari sediaan sirup ekstrak daun sirih merah (Piper crocatum Ruiz & Pav) terhadap bakteri Salmonella typhii. Penelitian ini menggunakan metode true experimental dengan rancangan post test only with control group design. Sampel yang digunakan pada penelitian ini adalah sirup ekstrak daun sirih merah  konsentrasi 5 %, 10 % dan 15 %. Evaluasi sirup meliputi uji organoleptis, homogenitas, pH. Kontrol positif yang digunakan adalah kloramfenikol dan kontrol negatif yang digunakan adalah sediaan sirup tanpa ekstrak. Sediaan sirup ekstrak daun sirih merah memiliki diameter zona hambat sebesar 32,19 mm. KHM pada konsentrasi 10% dengan nilai signifikansi 0,018 namun tidak memiliki nilai KBM. Sediaan sirup ekstrak daun sirih merah telah memenuhi evaluasi organoleptis, homogenitas, pH. Sirup ekstrak Daun Sirih Merah (Piper crocatum Ruiz & Pav) memiliki daya hambat minimum terhadap Salmonella typhii pada konsentrasi 10%.
Digital Marketing dalam Meningkatkan Keunggulan Kompetitif Kerupuk Singkong Desa Petung Kabupaten Gresik
Authors: Has Dwi Faqihatus Syarifah , Yuliati Luluk , Wulandari Dwi
Published: July 2024

The rapid development of technology has an impact on changes in behavior and people’s lives in all sectors. Technological progress cannot be avoided. Therefore, we must be able to use it wisely to support productivity in life, both in the sectors of Government, Culture, Education, and the Economy. The method used in the implementation of community service is ( socialization is carried out by exposing digital marketing materials; (2) education, namely providing an understanding of the importance of labeling on product packaging; (3) training and practice of making labels and Instagram social media for promotion and market product so that the marketing reach os its product is more comprehensive. This community service activity concludes that the socialization, education, training, and practice participants went well and succeeded; the cassava cracker business owner has put a unique name label (Krusava Ma’Yah) on the cracker packaging and has an Instagram @_krusava ma’yah, which was created and made by the trainees. It is hoped that the improvement in the condition of business actors after assistance will be able to increase the competitive advantage of cassava cracker product.
Þýðing og prófun á PREMIS
Authors: Jónsdóttir Sunna , Heimisson Guðmundur , Jónsdóttir Sigríður
Published: July 2024

Tilgangur
Ofbeldi er þekkt heilsufarsvandamál og mikilvægt að heilbrigðisstarfsmenn
hafi þekkingu og færni í að spyrja um ofbeldi og bregðast við því.
Spurningalistanum PREMIS (Physician Readiness to Manage Intimate
Partner Violence Survey) er ætlað að kanna þekkingu heilbrigðisstarfsfólks
varðandi ofbeldi. Tilgangur rannsóknarinnar var tvíþættur: 1) Að þýða,
staðfæra og athuga próffræðilega eiginleika íslenskrar útgáfu af PREMIS 2)
Að meta gildi PREMIS til notkunar fyrir íslenskt heilbrigðisstarfsfólk.

Aðferð
Tveir þýðendur þýddu PREMIS yfir á íslensku og þriðji þýddi hann aftur
á ensku til að athuga hvort merking listans hefði haldið sér í gegnum
þýðingarferlið. Þýðendurnir voru heilbrigðisstarfsmenn með góða enskuþekkingu ásamt þekkingu á íslenska heilbrigðiskerfinu. Fimm heilbrigðisstarfsmenn voru fengnir í hugarferlaviðtöl til að meta orðalag og inntak
PREMIS. Listinn var lagður fyrir úrtak heilbrigðisstarfsfólks á Íslandi
(n=177). Innra samræmi allra kvarða var reiknað með Cronbach´s alpha
og þáttagerð skoðanakvarðans var könnuð með meginhlutagreiningu
(e. Principal Components Analysis).

Niðurstöður
Áreiðanleiki PREMIS var mældur með Cronbach’s alpha og reyndist
a=0,71-0,98 eftir kvörðum. Þáttagreining gaf til kynna sjö skýra þætti.
Spurningarnar röðuðust ekki eins upp á þætti í íslensku útgáfu PREMIS
og þeirrar bandarísku, sérstaklega hvað starfsumhverfi og lagalega þætti
snerti, sem er auðskýranlegt með tilliti til þess hversu ólík heilbrigðiskerfi
þessara landa eru.

Ályktanir
Mat rannsakenda er að tekist hafi að staðfæra og aðlaga PREMIS að
starfsumhverfi íslensks heilbrigðisstarfsfólks. Þáttagerð listans er ekki
sú sama og í bandarísku útgáfunni en það kemur ekki á óvart þar sem
heilbrigðiskerfin tvö eru jafn ólík og raun ber vitni. Þáttagerð íslensku
útgáfunnar er hreinleg og áreiðanleiki í svörum viðunandi. Niðurstöður
rannsóknarinnar gefa sterklega til kynna að íslenska útgáfa PREMIS sé
áreiðanleg og viðeigandi til notkunar í íslensku heilbrigðiskerfi.

Lykilhugtök
PREMIS, staðfæring matstækja, forprófun, ofbeldi í nánum samböndum,
heilbrigðisstarfsfólk.
Outcome Of Prostatic Abscess By Transurethral Resection In Diabetic Patients
Authors: Chowdhury Atm Mowladad , Ahmed Bakhtiar , Khan Mohiur Rahman , Hasan Rafiqul , Rahman Shafiqur
Published: July 2024

Purpose: Prostatic abscess is an uncommon urologic disease but has a high mortality rate if not treated properly. Furthermore, diagnosis and proper treatment of prostatic abscess remain as a challenge for physicians. Transurethral resection of prostate in prostatic abscess is found very effective considering its rapid recovery. We compared data on transurethral resection of prostate (TURP), and transurethral incision of the abscess cavity (TUI) in 117 cases over a six and half year period.The details of surgical resection and all the followup visits were recorded and analyzed.
Results: With a mean age of 61.53 ± 8.58 years, all diabetic patients had multifocal abscess cavities. Seventy six men underwent classical TURP similar to the technique used for benign prostatic enlargement(group 1), other 41 men underwent modified transurethral incision of the abscess cavity (TUI) (group 2). The abscess cavities resolved completely, and no patient required a second intervention. One patient in group 1 and 6 in group2 had postoperative fever requiring parenteral antibiotics (P = 0.716), 23 patients in group 1 had transient urinary incontinence,whereas none of the patients in group 2 had this complication (P = 0.055). 24 and 2 men in group 1 and 2 reported retrograde ejaculation respectively (P = 0.740). For the alleviation of symptoms and to get the urine culture negative post-operative antibiotic treatment was needed to be continued in group 1 for 7 days and in group 2 for more than 14 days.
Conclusion: The modified resection technique of abscess cavity and formal TURPin the management of prostatic abscess give comparable outcome, but in diabetic patients as the abscess is multifocal transurethral resection ensures better drainage and faster postoperative recovery.
Bangladesh Journal of Urology, Vol. 20, No. 1, January 2017 p.8-12
Intersecting Identities, Gender and Health: A Mapping of Adolescent Health Challenges in Bangladesh
Authors: Fariha Tasnim Nowshin Fariha , Banu Ayesha Banu
Published: July 2024

This article discusses the importance of adolescent health and wellbeing for realising the dreams of future Bangladesh. Using data from secondary sources, the paper provides an overview of the challenges faced by adolescents with a focus on gender and intersectionality. Adolescents have unique health needs that are often neglected, and gender norms and values play a significant role in shaping access to resources and opportunities, eventually affecting the physical, mental, and sexual and reproductive health of males and females differently. The contemporary world becomes constrained for girls and they face additional health risks due to child marriage, childbirth, reduced contraception usage, gender-based violence, malnutrition, household and care giving responsibilities. On contrary, the world tends to open up for boys making them vulnerable to health risks like child labour, occupational injuries, physical violence, substance abuse, and suicide. Furthermore, the marginalised groups of adolescents including sexually diverse groups, children of sex workers, street children, orphans, disabled individuals, coastal and indigenous inhabitants face multiple layers of discrimination and health inequalities due to their geographical, socio-economic, gender and sexual identities. All of these diversities need to be taken into account while designing policies for addressing the specific health needs of different groups. Their health needs should be incorporated from a more holistic and broader perspective, using both gender and intersectional lens. This paper emphasises the necessity to include the perspectives and voices of diverse adolescent groups in policymaking to ensure appropriate and effective solutions.
Journal of the Asiatic Society of Bangladesh (Hum.), Vol. 69(1), 2024, pp. 33-65
Sketching the Tactical Position and Maritime Connectivity of Bengal with Malay Archipelago (321 BCE-750 CE)
Authors: Akhtar Sharmin Akhtar
Published: July 2024

This study examines the geographical and strategic proximity of Bengal and the interplay between the Bengal and Southeast Asian regions which two entities had a linkage and a great bonding from 321 BCE to 750 CE concerning maritime activities. At that time, Southeast Asia; mainly the Malay Archipelago was known as the Golden Chersonese. Despite having infinite reciprocal geographical and maritime significance, their tactical positions and strategic factors that impacted inter-linkages are seriously marginalised and infrequently looked at from the historical perspective. The study adopts historical research method in analysing the accounts of ancient Greek-Roman geographers and Chinese travellers, ancient texts, and archaeological documents qualitatively to unfold the contextual geographical factors between these two regions. The findings of this study show the strategic proximity of Bengal and its role in creating linkages with Southeast Asia through ports and maritime connectivity. It also demonstrates the socio-cultural impacts on the Southeast Asian regions created by the Bengal’s contacts during the ancient period.
Journal of the Asiatic Society of Bangladesh (Hum.), Vol. 69(1), 2024, pp. 123-143
Super-Twisting Sliding Mode and Fuzzy PID Hybrid Control System Integration for Electric Dynamic Load Simulation
Authors: Kumar Chandar , Ali Zahid , Yaqoob Muhammad Tayyab , Muddassir Ahmed , Hussain Sarfraz
Published: July 2024

In this paper, we present a control approach for an electric dynamic load simulator (EDLS) to obtain fast reaction times and accurate loading. We create an equation for the EDLS and use it to create a controller with the super-twisting sliding mode (STSM) method. The design is based on the constant monitoring inaccuracy of load. To allow dynamic and precise loading, the convergence condition for the finite duration of the STSM control law is established. We experiment with various frequencies and compare the performance of our suggested control method with a Fuzzy PID Control technique to validate its efficacy. The outcomes support the efficiency of our suggested control strategy.
Estudo preliminar da eficiência da eletrólise alcalina da água para produção de hidrogênio utilizando eletrodo ultrassônico
Authors: Menezes Christian Matheus Barbosa de , Sobral Daniel de Morais , Menezes Natalia Cristina Barbosa , Barbosa Alane Carvalho , Santos Leonardo Bandeira dos , Benachour Mohand , Santos Valdemir Alexandre dos
Published: July 2024

Este estudo apresenta uma pesquisa sobre o aumento da eficiência da eletrólise alcalina da água para produção de hidrogênio verde, utilizando eletrodo ultrassônico. O objetivo do trabalho foi investigar a eficiência da eletrólise alcalina da água utilizando eletrodos ultrassônicos, com foco na produção de hidrogênio verde e na sustentabilidade ambiental. A metodologia envolveu a utilização de uma célula eletrolítica de aço inoxidável, eletrodos de aço inoxidável 316L, e solução eletrolítica de KOH a 30% (p/p). Foi utilizado um gerador de ultrassom com potência de 20W e frequência de 40kHz, aplicando-se ultrassom diretamente ao eletrodo. A coleta de hidrogênio produzido foi realizada através de um sistema de deslocamento de água. O planejamento experimental seguiu um delineamento fatorial completo, com análise dos dados por meio de variância (ANOVA) e comparação de médias (Tukey). Foi evidenciado que a aplicação de ultrassom diretamente no eletrodo pode melhorar significativamente a eficiência da eletrólise, reduzindo a sobretensão e as resistências, e acelerando a formação de microbolhas de hidrogênio, resultando em um aumento de até 28% na produção de hidrogênio. Destaca-se a importância de otimizar parâmetros como a frequência e intensidade ultrassônica e a concentração do eletrólito, oferecendo uma abordagem promissora para tornar a produção de hidrogênio verde mais viável e econômica. Sugere-se a exploração de diferentes materiais de eletrodos e a integração desta tecnologia em sistemas de fontes renováveis de energia para futuras pesquisas.
Ophthalmological changes from the pregnant woman's point of view: A symptomatic analysis
Authors: Freitas Aston Alves de , Aguiar Alan Bessa , Procopio Thais da Cunha , Maia Livia de Melo , Custodio Kustodyo Feitosa , Souto Geovanna Hellen Pedrosa , Nogueira Marden de Carvalho , Ferreira Juliana de Lucena Martins
Published: July 2024

Introduction: During pregnancy, the eyes may undergo transient changes, which may, even rarely, affect visual functions. The present study aimed to understand the context and perception of ophthalmological changes in pregnant women. Methods: this is a descriptive, qualitative, and quantitative study conducted using a questionnaire via Google Forms between April and October 2023. The target population was pregnant women monitored by professionals at the Basic Health Units in Fortaleza, Ceará. The data was analyzed using Excel software and subjected to descriptive statistical analysis. Results: 52 responses were obtained from pregnant women. Most participants (69.2%) were in the third trimester of pregnancy, and most (96.2%) did not have periorbital chloasma. As for other ophthalmic changes, most pregnant women did not experience significant changes in ocular degree or intraocular pressure. A low frequency of ophthalmic consultations during pregnancy was observed, highlighting a gap in ophthalmic monitoring practices. Conclusion: the results highlight the importance of early screening for ophthalmic alterations during pregnancy, especially in pregnant women with risk factors, for more effective interventions and the promotion of maternal-fetal eye health. Raising awareness of the need for regular assessments can significantly contribute to the prevention and appropriate treatment of these alterations.
Comparação dos resultados da análise de folhas de café acondicionadas em diferentes tipos de embalagem
Authors: Silva Assis Brian Gabriel , Amaral Priscila Ferreira de Sales , Amaral Francisco Hélcio Canuto
Published: July 2024

Este trabalho teve como objetivo avaliar se houve diferença nos resultados da análise de folhas de café acondicionadas em embalagens de papel e de plástico (com furo e sem furo). Buscou-se ainda verificar se o tempo em que análise foliar foi realizada (oitavo dia e décimo quinto dia após a coleta) seguiu a mesma tendência observada para as amostras que foram coletadas e imediatamente analisadas. Para atingir o objetivo proposto, as folhas das plantas foram inicialmente recolhidas em uma fazenda localizada na região de Boa Esperança e então conduzidas ao laboratório para serem realizadas as análises. Avaliou-se os resultados por meio do emprego do Reconhecimento de Padrões não-supervisionado composto pela Análise de Agrupamentos Hierárquicos (HCA) e pela Análise de Componentes Principais (PCA). Foi verificado que independentemente do tipo de embalagem em que as folhas de café foram acondicionadas, há uma elevada similaridade entre as amostras analisadas no dia da coleta e no oitavo dia após a coleta, as quais, por sua vez, são distintas das avaliadas no décimo quinto dia após a coleta. Tais resultados permitem inferir que a influência do tempo após a coleta se sobrepõe à influência do tipo de embalagem.  Sendo assim, pode-se concluir que as folhas de café podem ser analisadas até o oitavo dia após serem coletadas, sendo acondicionadas em qualquer tipo de embalagem estudada (papel, plástico com furo e plástico sem furo).
Associação da circunferência do pescoço com variáveis sociodemográficas e clínicas de pacientes ambulatoriais
Authors: Santos Natalia Castaman dos
Published: July 2024

Introdução: a descoberta da circunferência do pescoço foi promissora por sua aplicabilidade prática e relação com alterações cardiometabólicas, sendo uma medida simples, de baixo custo e que complementa a avaliação do enfermeiro na identificação de riscos à saúde. Objetivo: associar a circunferência do pescoço com fatores de risco cardiovascular modificáveis e não modificáveis. Métodos: estudo descritivo, quantitativo e transversal realizado em um hospital quaternário filantrópico. A amostra por conveniência foi composta por adultos que realizaram ultrassonografia das artérias carótidas e com perfil lipídico, glicemia de jejum e hemoglobina glicada em prontuário. Foi aplicado um formulário para coleta de dados que continha variáveis sociodemográficas e clínicas. O peso e a altura foram aferidos em balança eletrônica com estadiômetro e a circunferência do pescoço foi aferida em posição ortostática, no ponto médio do pescoço, considerando circunferência do pescoço <37 cm para homens e <34 cm para mulheres. As associações entre variáveis quantitativas foram medidas pela correlação de Spearman e, entre as demais variáveis, foram usados testes como qui-quadrado. Resultados: as variáveis que apresentaram associação significativa positiva com a circunferência do pescoço foram sexo masculino, peso, altura, índice de massa corporal, tabagismo e carga tabágica. Somente o HDL-c apresentou associação significativa negativa. Conclusão: a circunferência do pescoço esteve associada ao sexo masculino, peso, altura, índice de massa corporal, tabagismo, carga tabágica e HDL-c, esse último com associação inversamente proporcional. Mostrou-se uma ferramenta confiável e um importante indicador de risco cardiovascular, fácil de ser viabilizada em serviços de Saúde Pública.
Beneficios del tratamiento ortodóntico en pacientes con periodonto reducido: Una revisión integral de la literatura
Authors: Naranjo Andrade Wilson Rolando , Ortíz Gutierrez José Luis , Chamba Aguirre Sofia Johana , Maldonado Alulima Nayeli Pauleth , Yunga Picón María Yolanda , Lafebre Carrasco Milton Fabricio , Dávila Arcentales Mónica Beatriz
Published: July 2024

El objetivo de este trabajo es realizar una revisión de la literatura sobre los beneficios del tratamiento ortodóntico en pacientes con periodonto reducido. Por tal, la metodología empleada fue una búsqueda de artículos científicos en PubMed, Scopus, ScienceDirect y Cochrane desde el año 2019 hasta el 2024 con términos MeSH, DeCs y terminología abierta. Además, criterios de elegibilidad idóneos para este estudio. Así, se propició un resultado de 876, de los cuales se escogieron 18 para esta revisión, siendo en su mayoría estudios de cohorte, además de incluir análisis de elementos finitos, revisiones sistemáticas con metaanálisis, estudios transversales prospectivos, ensayo clínico aleatorizado, revisión de la literatura y un estudio longitudinal. En conclusión, el tratamiento de ortodoncia permite una ganancia de CAL y reducción de PPD. Además, la alineación dental permite una higiene de fácil acceso, propiciando alterar el curso de la enfermedad periodontal. En el caso de recesiones gingivales la literatura no explica con claridad los beneficios que puede traer la ortodoncia, tema que queda abierto para futuras investigaciones.
PENGARUH BUDAYA ORGANISASI, KOMPENSASI DAN KOMITMEN ORGANISASIONAL TERHADAP KINERJA KARYAWAN PERKEBUNAN SAWIT
Authors: Junaedi Marliana ,   Fakultas Bisnis Universitas Katolik Widya Mandala Surabaya, Rahayu Dewi Sekar , Koesmono Teman ,   Fakultas Bisnis Universitas Katolik Widya Mandala Surabaya,   Fakultas Bisnis Universitas Katolik Widya Mandala Surabaya
Published: July 2024

The purpose of this study was to analyze the effect of organizational culture, compensation and organizational commitment on the performance of employees of Palm Oil Plantations in Kandis District, Siak Regency, Riau Province. Through this research, it is stated that the value of organizational culture can be used as a guideline and value in the company for each employee in improving their performance. And by providing compensation in accordance with what employees have done to this company affects employee performance in the future and also increases employee organizational commitment to stay in the plantation. There were 100 sample of respondents involved in this study. Multiple linear regression analysis techniques with the help of the SPSS program, were used in this study. The results of this study indicate that organizational culture, compensation and organizational commitment have a positive and significant effect on employee performance, so that all hypotheses are supported.
PENGARUH DIMENSI PSYCHOLOGICAL CAPITAL TERHADAP WORK ENGAGEMENT KARYAWAN GENERASI ZOOMERS (GEN Z) DI SURABAYA
Authors: Natalia Natalia ,   Fakultas Bisnis Universitas Katolik Widya Mandala Surabaya, Runtu Julius ,   Fakultas Bisnis Universitas Katolik Widya Mandala Surabaya
Published: July 2024

The zoomer generation (Gen Z) is starting to enter the world of work and will become the majority group in the future. The different characteristics that exist in each generation demand different approaches to get them more quickly involved in their work. This research is research at the dimensional level of psychological capital variables to analyze the influence of each dimension in order to find out which psychological capital dimensions have the most influence on work engagement of Gen Z employees. The sampling technique used was non-probability sampling using purposive sampling. The number of samples used was 235 Gen Z employees who live in Surabaya and have work experience of at least 1 year. Multiple linear regression was used to analyze the data. The results of the analysis show that self-efficacy, resilience, hope and optimism have a positive and significant effect on work engagement. The psychological capital dimension that has the most influence on work engagement of Gen Z employees is optimism.
Efektivitas Mutasi Transformator Dalam Mengatasi Fluktuasi Beban Pada Trafo Distribusi ULP Bululawang
Authors: Harrij Mukti K.  , Rachmat Sutjipto  , Vidiasih
Published: July 2024

Transformer is a very important component in the distribution of electricity from the distribution substation to consumers. Overloading and underloading of transformers can lead to significant inefficiencies and increased losses in the electrical distribution system. Based on data measurement of the ULP Bululawang transformer in 2022, it was found that the C0177 transformer (100 KVA) was overloaded (88.4%) and the C0254 transformer (160 KVA) was underloaded (21.4%). Load forecasting for 2027 predicts that the C0177 transformer load will reach 107%, causing overheating, while the C0254 transformer will remain underloaded at 23.68%. To address these issues, a transformer mutation was proposed. This study aims to evaluate the effectiveness of transformer mutation in redistributing loads and improving efficiency. The method involved measuring transformer loads before and after mutation and using the Least Square method for load forecasting. Post-mutation measurements showed the C0177 transformer load reduced to 62.6% and the C0254 transformer load increased to 37%. These results indicate that the transformer mutation significantly balanced the load distribution. The study also adjusted the protection settings, including FCO, output cable, main switch, PHB-TR, and NH Fuse output cable. The findings suggest that transformer mutation can effectively address load imbalances, improve operational efficiency, and reduce power losses in the distribution system.
NeMeHg, genetically encoded indicator for mercury ions based on mNeonGreen green fluorescent protein and merP protein from Shigella flexneri
Authors: Subach Oksana M. , Piatkevich Kiryl D. , Subach Fedor V.
Published: July 2024

The detection of mercury ions is an important task in both environmental monitoring and cell biology research. However, existing genetically encoded sensors for mercury ions have certain limitations, such as negative fluorescence response, narrow dynamic range, or the need for cofactor supplementation. To address these limitations, we have developed novel sensors by fusing a circularly permutated version of the mNeonGreen green fluorescent protein with the merP mercury-binding protein from Gram-negative bacteria Shigella flexneri. The developed NeMeHg and iNeMeHg sensors responded to mercury ions with positive and negative fluorescence changes, respectively. We characterized their properties in vitro. Using the developed biosensors, we were able to successfully visualize changes in mercury ion concentration in mammalian cultured cells.
Mitochondrial inorganic polyphosphate is required to maintain proteostasis within the organelle
Authors: Da Costa Renata T. , Urquiza Pedro , Perez Matheus M. , Du YunGuang , Khong Mei Li , Zheng Haiyan , Guitart-Mampel Mariona , Elustondo Pia A. , Scoma Ernest R. , Hambardikar Vedangi , Ueberheide Beatrix , Tanner Julian A. , Cohen Alejandro , Pavlov Evgeny V. , Haynes Cole M. , Solesio Maria E.
Published: July 2024

The existing literature points towards the presence of robust mitochondrial mechanisms aimed at mitigating protein dyshomeostasis within the organelle. However, the precise molecular composition of these mechanisms remains unclear. Our data show that inorganic polyphosphate (polyP), a polymer well-conserved throughout evolution, is a component of these mechanisms. In mammals, mitochondria exhibit a significant abundance of polyP, and both our research and that of others have already highlighted its potent regulatory effect on bioenergetics. Given the intimate connection between energy metabolism and protein homeostasis, the involvement of polyP in proteostasis has also been demonstrated in several organisms. For example, polyP is a bacterial primordial chaperone, and its role in amyloidogenesis has already been established. Here, using mammalian models, our study reveals that the depletion of mitochondrial polyP leads to increased protein aggregation within the organelle, following stress exposure. Furthermore, mitochondrial polyP is able to bind to proteins, and these proteins differ under control and stress conditions. The depletion of mitochondrial polyP significantly affects the proteome under both control and stress conditions, while also exerting regulatory control over gene expression. Our findings suggest that mitochondrial polyP is a previously unrecognized, and potent component of mitochondrial proteostasis.
Exploring the sedative properties of natural molecules from hop cones (Humulus lupulus) as promising natural anxiolytics through GABA receptors and the human serotonin transporter
Authors: Belal Amany , Elballal Mohammed S. , Al-Karmalawy Ahmed A. , Hassan Ahmed H. E. , Roh Eun Joo , Ghoneim Mohammed M. , Ali Mohamed A. M. , Obaidullah Ahmad J. , Alotaibi Jawaher M. , Shaaban Salwa , Elanany Mohamed A.
Published: July 2024

This research work aimed to identify the main components that are responsible for the sedative properties of hop cones and allocate their targets. This investigation was performed through molecular docking, molecular dynamic simulations, root mean square fluctuation (RMSF) analysis, and DFT calculation techniques. The tested compounds from Humulus lupulus were compared to diazepam and paroxetine. Molecular docking showed that two-thirds of the compounds had a good affinity to gamma-aminobutyric acid (GABA), outperforming diazepam, while only three surpassed paroxetine on the SERT. Compounds 3,5-dihydroxy-4,6,6-tris(3-methylbut-2-en-1-yl)-2-(3-methylbutanoyl)cyclohexa-2,4-dien-1-one (5) and (S,E)-8-(3,7-dimethylocta-2,6-dien-1-yl)-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one (15) showed stable binding and favorable energy parameters, indicating their potential for targeting GABA receptors and the SERT. This study provides a basis for future clinical research on these promising compounds.
Remote sensing object detection with feature-associated convolutional neural networks
Authors: Rao Jianghao , Wu Tao , Li Hongyun , Zhang Jianlin , Bao Qiliang , Peng Zhenming
Published: July 2024

Neural networks have become integral to remote sensing data processing. Among neural networks, convolutional neural networks (CNNs) in deep learning offer numerous advanced algorithms for object detection in remote sensing imagery, which is pivotal in military and civilian contexts. CNNs excel in extracting features from training samples. However, traditional CNN models often lack specific signal assumptions tailored to remote sensing data at the feature level. In this paper, we propose a novel approach aimed at effectively representing and correlating information within CNNs for remote sensing object detection. We introduce object tokens and incorporate global information features in embedding layers, facilitating the comprehensive utilization of features across multiple hierarchical levels. Consideration of feature maps from images as two-dimensional signals, matrix image signal processing is employed to correlate features for diverse representations within the CNN framework. Moreover, hierarchical feature signals are effectively represented and associated during end-to-end network training. Experiments on various datasets demonstrate that the CNN model incorporating feature representation and association outperforms CNN models lacking these elements in object detection from remote sensing images. Additionally, integrating image signal processing enhances efficiency in end-to-end network training. Various signal processing approaches increase the process ability of the network, and the methodology could be transferred to other specific and well-defined task.
Evaluation of low-temperature oxidation analysis and the development effect of high-pressure air injection in low-permeability reservoirs
Authors: Chen Xinyu , Ba Zhongchen , Lu Zhiyuan , Gao Yuhui , Zhou Yang , Li Xinrui
Published: July 2024

In order to solve the problems of conventional water injection development difficulties and low recovery factor in low-permeability reservoirs, the method of high-pressure air drive is adopted to achieve the purpose of reservoir energy enhancement and efficiency improvement. This paper conducted an experimental study on the mechanism of low-temperature oxidation (LTO) for crude oil in the process of high-pressure air flooding, elaborated the relationship between the LTO properties of crude oil and the temperature, pressure, and water saturation of the reservoir, and analyzed the differences in LTO oxygen consumption and oil components under different reaction conditions. In addition, combined with the air flooding physical simulation experiment, the dynamic evolution law of recovery rate in the air flooding process was revealed. Findings from this inquiry indicate that an escalation in the oxidation temperature significantly amplifies the oxygen incorporation reaction within the crude oil matrix. This augmentation in oxidative conditions leads to an uptick in oxygen consumption, which subsequently precipitates a reduction in the lighter fractions of the oxidized oil while enriching its heavier components. Elevated pressures were found to enhance the propensity for the amalgamation of unstable hydrocarbons with oxygen, fostering comprehensive and heterogeneous oxidation reactions. Notably, an excessive presence of water was observed to detrimentally affect the thermal efficacy of crude oil oxidation processes. In the context of low-permeability reservoirs, air injection techniques have emerged as superior in effectuating oil displacement, although an increase in injection pressures has been associated with the phenomenon of gas channeling. Interestingly, adopting a sequential strategy of initiating water flooding before air flooding facilitated the conveyance of high-pressure air via established flushing channels, although it appeared to attenuate the intensity of crude oil oxidation, culminating in an oil recovery efficiency peaking at 51%.
Simulation of lower Cambrian oil and gas generation and phase evolution process in ZH1 of Tazhong area
Authors: Luo Xinsheng , Yang Chunlong , Zhao Qing , Cheng Ming , Zhang Ke , Su Jin , Li Dengke
Published: July 2024

The Lower Cambrian petroleum system in the Tarim Basin has undergone multiple periods of tectonic movements, leading to successive hydrocarbon expulsion events and adjustments. The complex process of hydrocarbon accumulation occurred under deep burial conditions, persisting at depths of nearly 6,000 m over an extended period. This has resulted in the current occurrence of various phases including light oil, condensate, and gas in the deep-ultradeep strata of the Tarim Basin. The intricacies of formation of hydrocarbon accumulations and phase evolution have posed challenges to understanding the accumulation mechanisms and enrichment patterns of the Cambrian in the Tarim Basin, consequently lowering the success rate of oil and gas exploration. Such characteristics of multi-stage accumulation and adjustment are prevalent in deep hydrocarbon systems. Therefore, based on data from Well ZH1 in the Tazhong Uplift, combined with basin simulation, Compositional kinetics model, and PVT performance simulation, this study investigates the hydrocarbon generation and phase evolution processes in the deep hydrocarbon systems of the Tazhong Uplift. The results indicate that Well ZH1 entered the hydrocarbon generation peak during the Late Ordovician, followed by secondary cracking as the predominant hydrocarbon evolution process. Hydrocarbon fluids within the Lower Cambrian reservoir transitioned into the condensate phase towards the end of the Cambrian, with increasing depth resulting in higher gas-oil ratios and a decreasing trend in viscosity and density.
Exploring the factors influencing high school students' deep learning of English in blended learning environments
Authors: Shi Hong , Lan Peng
Published: July 2024

Exploring deep learning and its influencing factors is receiving increasing attention. This study examines influencing factors (i.e. self-efficacy, learning engagement, and teacher-student interaction) of high school students' English deep learning in blending courses. Research hypotheses are proposed, and a structural equation model (SEM) of influencing factors of deep learning is built. A sample size of 225 participants was recruited on a voluntary and anonymous basis from a high school in Southwestern China for this study. We find: (1) self-efficacy, learning engagement and teacher-student interaction all predict and have positive impacts on English deep learning; (2) self-efficacy has a positive impact on learning engagement and teacher-student interaction; (3) teacher-student interaction has a positive impact on learning engagement. The findings underscore the importance of self-efficacy, learning engagement, and teacher-student interaction for EFL high school learners to achieve deep learning in a blending context. Drawn from these findings, pedagogical implications for promoting these learners' deep learning are provided.
Novel PRKAR1A mutation in Carney complex: a case report and literature review
Authors: Zheng Huaqiang , Kang Hong , Qiu Yizhen , Xie Liangxiao , Wu Jinzhi , Lai Pengbin , Kang Jiapeng
Published: July 2024

Objective

Carney complex is a rare autosomal dominant syndrome that has been shown to be associated with inactivation due to PRKAR1A mutations. We revealed a novel PRKAR1A gene mutation in Chinese patient with Carney complex and review the literature to enhance understanding of Carney complex.

Case presentation

A 23-year-old Chinese male patient with a family history cardiac myxoma was admitted to our Department of Endocrinology because of central obesity and hyperpigmentation. Physical examination revealed a maximum blood pressure of 150/93mmHg, a waist circumference of 102cm, a weight of 70kg, a height of 170cm, and a BMI of 24.22kg/m2. Additionally, there was spotty skin pigmentation on the lip mucosa, purple striae on the abdomen, thin skin on both legs, and visible veins. Blood examination revealed hypercortisolemia, decreased adrenocorticotropic hormone (ACTH) levels and failure to suppress cortisol with low and high-dose dexamethasone suppression tests. Magnetic resonance imaging (MRI) scan revealed multiple small adrenal nodules and Retroperitoneal neurogenic tumor. Genetic testing showed a novel heterozygous mutation in exon 5 of PRKAR1A (c.500_502 + 8delAAGGTAAGGGC). The patient underwent resection of the right adrenal gland and retroperitoneal neoplasms in 2020. Postoperative pathology following the right adrenal gland resection showed nodular hyperplasia of the adrenal cortex. The pathology from the retroperitoneal tumor resection revealed spindle cell tumors rich in pigment and cells. The patient was diagnosed as Carney complex according to Stratakis CA in 2001 guidelines. After long-term follow-up, the patient’s condition was stable, with weight loss, waist circumference reduction, significantly lower cortisol levels, and normal blood lipids.

Conclusion

This case reported a Carney complex in a Chinese patient, characterized clinically by non-ACTH-dependent Cushing’s syndrome, familial recurrent cardiac myxomas, psammomatous melanotic schwannoma (PMS) and skin and mucosal pigmentation. A novel subtype of PRKAR1A mutation was discovered, which may affect the characteristics of the PRKAR1A protein and contribute to the development of Carney complex.
Association between fatty acids intake and bone mineral density in adolescents aged 12-19: NHANES 2011–2018
Authors: Wang Zhi-Gang , Fang Ze-Bin , Xie Xiao-Li
Published: July 2024

Background

The relationship between the intake of dietary fatty acids (FA) and bone mineral density (BMD) has been the subject of prior investigations. However, the outcomes of these studies remain contentious. The objective of this research is to examine the link between dietary FA consumption among adolescents and BMD.

Methods

This study utilized high-quality data from the National Health and Nutrition Examination Survey database, spanning 2011 to 2018, to explore the association between dietary fatty acids and bone health indicators in adolescents, including BMD and bone mineral content (BMC). Analyses were performed using weighted multivariate linear regression models, incorporating detailed subgroup analysis.

Results

The study included 3440 participants. Analysis demonstrated that intake of saturated fatty acids (SFA) was positively correlated with total BMD, left arm BMD, total BMC, and left arm BMC. Monounsaturated fatty acid (MUFA) intake was positively correlated with BMC across most body parts, though it showed no correlation with BMD. Intake of polyunsaturated fatty acids (PUFA) was significantly inversely correlated with both BMD and BMC in most body parts. Additionally, subgroup analysis indicated that variables such as sex, age, standing height, and race significantly influenced the correlation between FA intake and BMD.

Conclusions

Our study indicates that dietary intake of SFA may benefit to BMD in adolescents, in contrast to PUFA and MUFA. Therefore, we recommend that adolescents maintain a balanced intake of SFA to promote optimal bone mass development while preserving metabolic health.
Bibliometric and literature synthesis on assisted natural regeneration: an evidence base for forest and landscape restoration in the tropics
Authors: Oluwajuwon Tomiwa V. , Chazdon Robin L. , Ota Liz , Gregorio Nestor , Herbohn John
Published: July 2024

Assisted Natural Regeneration (ANR) is a set of restoration strategies and interventions primarily based on natural regeneration, aimed at accelerating succession and providing multiple benefits in degraded ecosystems and landscapes. These strategies have the potential to significantly contribute to global Forest and Landscape Restoration efforts. However, ANR faces challenges due to limited recognition, support, and formal integration into relevant sectors and restoration policies, particularly in tropical regions. The dearth of evidence-based syntheses further compounds these challenges. To address this gap, a bibliometric analysis of selected scientific publications on ANR (n = 208) from 1987 to 2023 was conducted, using Web of Science and Google Scholar databases. A systematic review was undertaken, using a subset of original research articles (n = 44), to synthesize published data on interventions, contexts, costs, and benefits of ANR and to identify major knowledge gaps. Analysis of bibliometric metadata revealed an increasing annual output of ANR publications in over 80 journals, encompassing various document types and authors from over 40 countries. Despite ANR’s formal emergence in the Philippines, Brazil has taken the lead in both its research and implementation, and international collaboration in ANR research has grown. While ANR research focused mostly on ecosystem services and ecological outcomes, social aspects have been poorly studied. Diverse ANR interventions align not only with ecological restoration but also with integrated land management, biodiversity conservation, forest and landscape restoration, and forest management. The cost-effectiveness of ANR implementation, especially in restoration for carbon storage, exhibited considerable variability when compared to active tree planting, and varied with intervention types, time, land use history, and long-term costs. This synthesis provides critical insights and evidence to enhance the effective integration of ANR into restoration and reforestation programs and policies.
Relationships between systemic sclerosis and atherosclerosis: screening for mitochondria-related biomarkers
Authors: Wang Fei , Lyu Xiao Yan , Qin Yi Ming , Xie Mei Juan
Published: July 2024

Background

Patients with systemic sclerosis (SSc) are known to have higher incidence of atherosclerosis (AS). Mitochondrial injuries in SSc can cause endothelial dysfunction, leading to AS; thus, mitochondria appear to be hubs linking SSc to AS. This study aimed to identify the mitochondria-related biomarkers of SSc and AS.

Methods

We identified common differentially expressed genes (DEGs) in the SSc (GSE58095) and AS (GSE100927) datasets of the Gene Expression Omnibus (GEO) database. Considering the intersection between genes with identical expression trends and mitochondrial genes, we used the least absolute shrinkage and selection operator (LASSO) as well as random forest (RF) algorithms to identify four mitochondria-related hub genes. Diagnostic nomograms were then constructed to predict the likelihood of SSc and AS. Next, we used the CIBERSORT algorithm to evaluate immune infiltration in both disorders, predicted the transcription factors for the hub genes, and validated these genes for the two datasets.

Results

A total of 112 genes and 13 mitochondria-related genes were identified; these genes were then significantly enriched for macrophage differentiation, collagen-containing extracellular matrix, collagen binding, antigen processing and presentation, leukocyte transendothelial migration, and apoptosis. Four mitochondria-related hub DEGs (IFI6, FSCN1, GAL, and SGCA) were also identified. The nomograms showed good diagnostic values for GSE58095 (area under the curve (AUC) = 0.903) and GSE100927 (AUC = 0.904). Further, memory B cells, γδT cells, M0 macrophages, and activated mast cells were significantly higher in AS, while the resting memory CD4+ T cells were lower and M1 macrophages were higher in SSc; all of these were closely linked to multiple immune cells. Gene set enrichment analysis (GSEA) showed that IFI6 and FSCN1 were involved in immune-related pathways in both AS and SSc; GAL and SGCA are related to mitochondrial metabolism pathways in both SSc and AS. Twenty transcription factors (TFs) were predicted, where two TFs, namely BRCA1 and PPARγ, were highly expressed in both SSc and AS.

Conclusion

Four mitochondria-related biomarkers were identified in both SSc and AS, which have high diagnostic value and are associated with immune cell infiltration in both disorders. Hence, this study provides new insights into the pathological mechanisms underlying SSc and AS. The specific roles and action mechanisms of these genes require further clinical validation in SSc patients with AS.