bluuebunny/crossref_metadata_2025 huggingface dataset:
An Infinite Capacity Single Server Markovian Queueing System With Discouraged Arrivals Retention Of Reneged Customers and Controllable Arrival Rates With Feedback
Authors: Bebittovimalan A ,   PG & Research Department of Mathematics, St. Joseph’s college (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli – 02, Tamil Nadu, Thiagarajan M
Published: August 2024

Objectives: The purpose of this study is to (i) introduce an infinite capacity of interdependent queueing model and retention of reneged customers with feedback controllable arrival rates, (ii) compute the mean quantity of clients within the system and determining the anticipated waiting time of those clients, (iii)deal with the model descriptions, steady-state equations, and characteristics, which are expressed in terms and (iv) analyze the probabilities of the queueing system and its characteristics with numerical verification of the obtained results. Methods : The Poisson process is used to manage the arrival rates through quicker and slower arrival rates while delivering the input. The service additionally offers an exponential distribution. The service is supplied by the server using FCFS. In this article, two types of models are used which are the system’s conditions, where represents the number of units present in the queue in which their probability and all probabilities are distributed based on the speed of advent using this concept. Then, the steady-state probabilities are computed using a recursive approach. Findings: This paper discovers the number of clients using the system on average and the expected number of clients in the system using the probability of the steady-state calculation. Little’s formula is used to derive the expected waiting period of the clients in the system. Novelty: There are articles connected to the finite capacity of failed service in functioning and malfunctioning, but this takes the initiative to provide a link in connection with the rates of the controllable arrivals and inter dependency in the arrival and service processes. Mathematics Subject allocation: 60K25, 68M20, 90B22. Keywords: Infinite Capacity, Interdependent Controllable, Arrival and Service rates, Reverse balking, Single Server, Bivariate Poisson process and feedback
Improving Wireless Sensor Network Security: Multifaceted 5G Protections Enhanced by Restoring Algorithm
Authors: Nirisha Anagandula ,   MLR Institute of Technology, Hyderabad, 500043, Telangana, India, Rasagnya Aenugu , Uriti Sahiti , Jain Himanshu
Published: August 2024

Objective: To develop the security Algorithm for 5G Wireless Sensor Networks (WSNs) to enhance security using the Restoring algorithm. Methods: Initially a security code is generated from the restoring algorithm and is used to construct an initial level of security. Here we make use of simple mathematical logic to obtain various security codewords for different security levels. The proposed approach improves the security of 5G WSNs against several security threats. For testing the presented approach, we consider Packet Delivery Ratio (PDR) and Delay as parameters for result comparison, moreover, Network Simulator is used to validate the technique of the proposed. Findings : The proposed method can be employed in 5G WSNs to minimize the current weaknesses and reinforce the security against possible security threats (i.e. Black hole attacks, session hijacking, DoS attacks, etc.). Besides, the presented approach can be used to protect against cyber threats. Novelty: The proposed method combines the necessary security features generated from the restoring algorithm and simple logical mathematics with 5G WSNs to develop the basic layer of security. With the application of logical mathematics, more security codes have been employed to provide different levels of security and as a result, it improves the 5G WSN security by efficiently optimizing the security threats. Keywords: Restoring Algorithm, Digital codes, 5G WSNs, Network simulator, Security
The Role of High-Fidelity Simulation in Nursing Education in Saudi Arabia
Authors: Abusabeib Zeinab A ,   Department of Community and Psychiatric Mental Health Nursing, College of Nursing, Princess Nourah bint Abdulrahman University, 11671, Riyadh, Saudi Arabia, Almadni Noura A , Alsenany Samira Ahmed , Ibrahim Hala K
Published: August 2024

Background: Nursing education needs to prepare competent nurses to provide high-quality care to clients, as a nurse's role has expanded and requires more professional abilities and self-sufficiency. However, nursing schools face significant challenges due to a shortage of educators, limited clinical areas or healthcare facilities, and an increasing number of students. To improve students' learning outcomes and enhance their self-confidence, satisfaction level, communication skills, and critical thinking abilities, nursing schools use high-fidelity simulation to allow students to practice procedures before implementing them in real life.This study examines undergraduate nursing students' perceptions of high-fidelity simulation-based learning, evaluates its impact on student confidence and satisfaction, and investigates the interrelationships between these elements and demographic characteristics after training nurse educators on high-fidelity simulation. Methods: The nurse educators received a pre-training program in high-fidelity simulation techniques. A self-administered questionnaire was used to evaluate students' perceptions of satisfaction and self-confidence after completing simulation-based practice. The data collected from 250 nursing students were analyzed using a descriptive analysis and Pearson correlation test. Findings: The mean score of students' self-confidence after experiencing a High-fidelity simulation is 3.08 out of 4. Additionally, the overall satisfaction acquired is 3.06 out of 4. Satisfaction correlates significantly with academic levels (p < 0.05). Undergraduate nursing students positively perceive the use of simulation in clinical education, as it enhances their satisfaction with learning and increases self-confidence. It is essential to offer ongoing professional development opportunities for nursing faculty to improve their abilities in using High-fidelity simulation effectively in teaching and assessment. Keywords: High­fidelity, Simulation, Satisfaction, Self­confidence, Nursing students
Magnetostratigraphy and Sedimentology of Deccan Intertrappean Succession from Sagar, Central India: Insights into Palaeoenvironment and End-Cretaceous Palaeogeography
Authors: Singh Sarvendra Pratap , Singh Arvind Kumar , Arif Mohammad , Prasad Vandana , Venkateshwarlu Mamilla , Naik Amiya Shankar
Published: August 2024

The study of Deccan volcano-sedimentary successions is significant for understanding the palaeomagnetic correlation, eruption history and palaeoenvironmental conditions of the Central India during the Cretaceous-Paleogene (K-Pg) transition. In this study, we applied an integrated magnetostratigraphic and sedimentological approach to the Deccan Intertrappean Succession exposed at the Mothi Hill (Malwa Subprovince), Sagar, to provide palaeomagnetic age constraints for the lava flows, depositional environment and end-Cretaceous palaeogeography. Palaeo-magnetic data suggest that the lower and upper Trap lava flows associated with the Mothi Intertrappean deposits are not coeval, and they correspond to C29r and C29n magnetochrons, respectively, which points to the age duration of 66.3–65.1 Ma (late Maastrichtian-early Danian). The palaeomagnetic data also marks the presence of upper magnetic polarity transition (C29r/C29n) in the eastern part of the Malwa Subprovince, which indicates the occurrence of C30n-C29r-C29n magnetostratigraphic sequence for the Subprovince. The Malwa, eastern Mandla and Western Ghats Subprovinces can be palaeomagnetically correlated and are partly synchronous with each other.

The Mothi Intertrappean deposition occurred in a low energy shallow water lacustrine setup with swampy to brackish depositional condition similar to shallow coastal lake type environment. The occurrence of such coastal type depositional environment at Sagar in the central part of India, points to the influence of temporary marine incursion and existence of marine pathway up to Central India, possibly through the western corridor of Narmada-Tapti rift zone during the late Maastrichtian-early Danian period. Moderate to intense chertification within the argillaceous limestone suggests post-depositional diagenetic modification and secondary silica generation due to interaction with silica enriched meteoric water diagenesis.
Agrobacterium-mediated transformation of Diplodia sapinea v1
Authors: Geertje Oostlander Anne , Brodde Laura
Published: August 2024

This protocol details an Agrobacterium-mediated genetic transformation method for the fungal plant pathogen Diplodia sapinea. The technique results in high rates of homologous integration, enabling both targeted mutagenesis and heterologous gene expression.
Nuclei Isolation from Human Subchondral Bone for 10x Multiome v1
Authors: Sakamoto Takuya , Olmer Merissa , Lotz Martin
Published: August 2024

This protocol describes isolation of nuclei from fresh-frozen human knee subchondral bone for use in Omics analyses, including RNA-sequencing of ATAC-sequencing. Tissue dissociation was the most critical step in optimization which was monitored by nuclei yield, integrity and purity. Methods for quality control are also described.
Fomento de la salud en pacientes con diabetes mellitus tipo 2 de las unidades de salud familiar del distrito de Limpio, Paraguay, 2022
Authors:   Ministerio de Salud Pública y Bienestar Social de Paraguay, Núñez Fátima , Méndez Julieta ,   Ministerio de Salud Pública y Bienestar Social de Paraguay, Espinola de Canata Miriam ,   Ministerio de Salud Pública y Bienestar Social de Paraguay, Rolón Angel ,   Ministerio de Salud Pública y Bienestar Social de Paraguay
Published: August 2024

Objetivo: Evaluar las estrategias de fomento de la salud en pacientes con diabetes mellitus tipo 2 de las unidades de salud familiar del distrito de Limpio, Paraguay, 2022. Metodología: Enfoque cuantitativo, descriptivo de tipo observacional, con dos valoraciones secuenciales. Fueron seleccionados 299 sujetos del Programa de Prevención y Modelo de Cuidados Crónicos para las Unidades de Salud Familiar de Limpio, proyecto de la agencia koica, “hefa ‘Salud para Todos’”, en particular del subprograma de pacientes crónicos con diabetes mellitus tipo 2, de 19 unidades de salud familiar de la ciudad de Limpio. Se utilizaron los datos registrados en el programa informático del Proyecto. Se caracterizaron los pacientes incluidos y, posteriormente, se describieron las orientaciones dadas por los médicos como estrategia para el fomento de la salud. Además, se realizaron dos valoraciones (antes/después) en cuanto a medidas antropométricas. Resultados: Del total de 299 sujetos con diabetes mellitus tipo 2 que cumplieron con los criterios de inclusión y exclusión, el 15,72 % contaba con antecedente de diabetes. Respecto a las orientaciones, el 45,82 % recibió algún tipo de orientación sobre hábitos saludables, 38,46 % sobre actividad física, 11,71 % sobre consumo de alcohol y 35,45 % sobre el consumo de medicamentos. Solo se registraron dos casos de complicaciones, los cuales correspondieron a pie diabético. Se registró que no hubo un cambio de hábitos entre la primera y última consulta para el hábito de ejercicios. Conclusión: En cuanto a las estrategias de fomento de la salud que se encontraron desde la perspectiva de la salud pública, este programa se enfocó a orientaciones y educación permanente de los pacientes en cada consulta, haciendo seguimiento del cumplimiento de las mismas.
Trastornos de conducta alimentaria y de la ingesta de alimentos en mujeres que solicitan procedimientos estéticos
Authors: Sánchez López John Irvin , Deossa Restrepo Gloria Cecilia ,   Universidad de Antioquia, Lopera-Gallego Gustavo ,   Universidad de Antioquia, González-Gómez Difariney ,   Universidad de Antioquia
Published: August 2024

Objetivo: Explorar la frecuencia de la presencia de síntomas de trastornos de conducta alimentaria y de la ingesta de alimentos en mujeres solicitantes de procedimientos de contorno corporal, en un centro de estética de Medellín-Colombia. Metodología: Estudio transversal, con 107 mujeres de 18 a 50 años. Se tomaron datos antropométricos, se implementó la versión en español del Eating Disorders Examination Questionnaire. Los datos se analizaron mediante frecuencias relativas y medidas de resumen y se realizó un análisis bivariado. Se construyeron modelos de regresión logística, con la significancia global como variable dependiente. Resultados: Hubo significancia clínica para riesgo de trastornos de conducta alimentaria y trastornos de la ingesta de alimentos en 6,5 % de las mujeres y en cada subescala del cuestionario (restricción: 3,7 %; preocupación por la comida: 4,7 %; por la figura: 36,4 %; y por el peso: 20,6 %). El 98 % reportó al menos un síntoma relacionado con los trastornos de conducta alimentaria y trastornos de la ingesta de alimentos. Se halló significación estadística entre la edad, el índice de masa corporal y la significancia clínica global del cuestionario. Al considerar la preocupación por la figura como variable dependiente, se identificó significación estadística en el perímetro de cintura rp = 1,14 (1,07-1,21). Conclusión: Hay presencia de síntomas y casos probables de trastornos de conducta alimentaria y trastornos de la ingesta de alimentos en mujeres solicitantes de procedimientos de contorno corporal, encontrando preocupación por su figura y realización de conductas que pueden afectar la salud. Se sugiere implementar protocolos de tamizaje para confirmar la posible aparición de estos trastornos y atenderlos oportunamente.
Los “Calikanjigramas” de Noni Lazaga
Authors: Muñiz de la Arena Antonia , Garcés García Pilar
Published: August 2024

El presente artículo tiene como objetivo introducir al lector en la presentación y análisis del “calikanjigrama”. Un término inventado por Noni Lazaga para designar sus poemas visuales, creados a partir de la deconstrucción de los kanji o ideogramas japoneses, y que la artista define como “caligrama de kanji”. A través un análisis sintáctico, semántico y filológico, con imágenes de las obras, se define el concepto de “calikanjigrama”, se explican las técnicas y el proceso creativo llevado a cabo. Se muestran modelos, tipologías y líneas de investigación desarrolladas por Lazaga desde su origen, en 2017, hasta la actualidad. Asimismo, se introducen los libros y otros formatos de publicaciones en los que aparecen citados, así como las exposiciones realizadas con los dibujos originales y el análisis filológico de autor Y. Como conclusión se extrae que en los “calikanjigramas”, Lazaga realiza un trabajo en el que relaciona dibujo, poesía visual y escritura japonesa. En su investigación interdisciplinar X e Y coinciden, a través de un análisis que entrelaza la estética oriental y occidental, en destacar resultados estéticos y conceptuales innovadores.
“The doctors guide to the correct examination of dead human bodies...” by I.V. Buyalsky (1824): the first original Russian guide to forensic medical examination
Authors: Barinov Evgeny Kh. , Smirnov Askold V. , Chetverikova Ekaterina A. , Mamchur Varvara K.
Published: August 2024

The year 2024 marks the 235th anniversary of the birth of Ilya Vasilyevich Buyalsky, an outstanding Russian surgeon, anatomist, and forensic physician and Honored Professor of the Imperial Medical and Surgical Academy and academician of the Imperial Academy of Arts. Another anniversary date of this year is associated with Buyalsky’s name: exactly 200 years ago, “The doctors guide to the correct examination of dead human bodies for finding the cause of death, especially in forensic cases,” which was the first original domestic manual on forensic medical examination, was published in the Military Medical Journal. This article comprehensively examined the history of the creation of this work, its main points, and its significance for subsequent generations of Russian forensic medical experts.
The article provides information about the activities of Buyalsky in the field of forensic medical examination. An analysis of his work “The doctors guide to the correct examination of dead human bodies...” is presented.
The present study shows that Buyalsky was one of the founders of forensic thanatology in our country, and the main provisions of “The doctors guide to the correct examination of dead human bodies...” remain relevant to date.
Influencia de los determinantes macroeconómicos en las metas de reducción de pobreza monetaria en Paraguay. Periodo 1997 - 2020
Authors: Boccia-Galiano Benjamín María
Published: August 2024

Este trabajo tiene como objetivo estimar la influencia de los determinantes macroeconómicos en la consecución de las metas de reducción de pobreza monetaria en Paraguay durante el período 1997-2020. Los determinantes macroeconómicos analizados son el PIB, el IPC, el índice de Gini y el gasto social. Para el efecto, se propone la aplicación de un modelo econométrico, el cual, a partir de modelos de regresión, permite calcular la incidencia de cada una de las variables analizadas sobre la pobreza monetaria. Además, se realizan proyecciones para inferir si se pueden cumplir o no con los objetivos del ODS 1 y bajo qué condiciones. Los resultados obtenidos permiten afirmar, por un lado, que todos los determinantes analizados inciden significativamente sobre la pobreza monetaria y, por otro lado, permiten inferir que ninguna de las metas se puede cumplir al 2030, ya sea manteniendo constante o incluso aumentando el crecimiento económico. Esto permite concluir que la eficacia en las estrategias de reducción de pobreza radica en combinar esfuerzos que vinculen el aumento del PIB con la redistribución equitativa de recursos y la inversión social.
Indicadores qualitativos na avaliação da pós-graduação em educação
Authors: Verhine Robert Evan , Dantas Lys Maria Vinhaes , Souza Ângelo Ricardo de
Published: August 2024

Analisa-se a avaliação da pós-graduação na Área de Educação da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, entre 2017 e 2020, destacando as mudanças decorrentes da ampliação do uso de indicadores qualitativos. Após a contextualização da avaliação e a discussão de aspectos teóricos sobre o tema, descreve-se o processo adotado para a objetivação da avaliação e os resultados obtidos, por análise de regressão, do comportamento dos indicadores quanti e qualitativos na definição das notas dos programas da área. Propõem-se redução do número de indicadores, valorização de indicadores qualitativos como fontes para o feedback necessário à melhoria do programa e adoção de processos de objetivação derivada da construção de critérios avaliativos que parametrizem o trabalho da avaliação.
Mucormycosis during the COVID-19 pandemicOur takeaways
Authors: Singh Rakesh Kumar , Jha Shruti , Mala Mani
Published: August 2024

is a rare, opportunistic fungal infection that affects immune-compromised hosts. When involving the PNS, it can be Rhino-orbital or Rhinocerebral and may rapidly prove fatal.

We present a retrospective case series analysis of 48 patients from the COVID-19 pandemic, our management of them, and our takeaways.

Out of 48, 12 had a previous history of oxygen therapy, 32 had tested positive for COVID-19 recently,8 had a history of ICU admission, and the most common occupations affected were homemakers and housewives. Grade 2 and 3 of rhino-orbital cerebral (ROCM)were most commonly found, and 28 developed type 2 diabetes before and after ROCM and 4 in the aftermath of the disease.

A high degree of suspicion should be maintained in all patients with nasal, orbital, or neuro complaints with a previous history of COVID-19 infection and with or without co-morbid conditions.
OPTICA ATOMICA ¿LA OPTICA DEL AÑO 2000?
Authors: M. Guzmán Angela
Published: August 2024

En óptica atómica los papeles de la luz y la materia se invierten con respecto a los de la óptica convencional, dando origen a la posibilidad de manipular átomos con láseres. Esta revisión versa sobre los fundamentos y desarrollos recientes de la Optica Atómica: los métodos de enfriamiento y confinamiento de átomos con láseres, la formación de redes de potencial óptico, la obtención del Condensado de Bose-Einstein (BEC) y el "láser de átomos". Se describen los rangos esenciales del condensado y de los diferentes modelos teóricos propuestos para la obtención de un haz atómico coherente, señalando los retos tecnológicos involucrados en su implementación. Se mencionan algunas perspectivas y posiblidades de aplicación.
A NEW FROG (GENUS ELEUTHERODACTYLUS) FROM CLOUD FORESTS OF SOUTHERN BOYACA
Authors: D. Lynch John
Published: August 2024

A new species of Eleutherodactylus is described from a single locality in southern Boyacá. lt is the sister species of E. nervicus, known from the páramos associated with Laguna Chingaza in Departamento Cundinamarca. The new species is larger than E. nervicus and has larger digital disks.
JUNTURAS JOSEPHSON BASADAS EN SUPERCONDUCTORESDEALTATEMPERATURA
Authors: Prieto Pedro , Lopera Wilson
Published: August 2024

La mayor parte de las aplicaciones de la superconductividad en electrónica están basadas en el efecto Josephson. La fabricación de dispositivos Josephson basados en superconductores de alta temperatura (SATC) ofrece altas temperaturas de trabajo y un mayor rendimiento. Sin embargo, las complejas características de estos materiales generan una gran variedad de problemas que se deben sortear para el desarrollo de dispositivos de buena calidad basados en estos compuestos. En este artículo se describen las características principales del efecto Josephson y los diferentes sistemas desarrollados para elaborar junturas Josephson con SATC. Se hace énfasis en las junturas Josephson de frontera de grano mostrando cómo se logra aumentar el rendimiento de las muestras dopando el YBa2Cu3O7-x con plata. Finalmente, se describe la elaboración y caracterización de dispositivos tipo escalón basados en Bi2Sr2CaCu2O8+x que se comportan como una serie de junturas Josephson apiladas y presentan valores significativamente grandes de la figura de mérito.
CAMBIOS DE FASE EN LA ATMÓSFERA: ¿PROCESOS IRREVERSIBLES?
Authors: Pelkowski Joaquín
Published: August 2024

Se tienen en cuenta dos fases del agua en la atmósfera para examinar la cuestión de si los cambios de fase son procesos irreversibles. Se señalan algunas dificultades en decidir si tales cambios son, en ciertos procesos atmosféricos, reversibles o no. Se procura justificar la conclusión de que los ciclos adiabáticos, y aún las transformaciones adiabáticas, no pueden ser irreversibles si el espacio de estados se define como lo hacen tradicionalmente los meteorólogos. No obstante, generalizando la noción clásica de estado, los ciclos adiabáticos pueden no ser necesariamente reversibles. Tal como está, el problema teórico de la irreversibilidad de los cambios de fase está vinculado a la definición de estado. Carecemos de evidencia empírica (y bibliográfica) acerca de si los cambios de fase en la atmósfera son irreversibles o no
POLIMORFISMO GENÉTICO DEL MHC Y SU ASOCIACIÓN CON LA INFECCIÓN HTLV-II
Authors: Egea MD Eduardo
Published: August 2024

Introducción. Las infecciones causadas por los virus que infectan los linfocitos T del humano (HTLV-I y II), parecen tener una distribución geográfica y étnica entre amerindios y otras poblaciones nativas en el mundo. En Colombia existe un foco endémico entre afrocolombianos del litoral Pacífico, no así en la costa del Caribe.
De otra parte, se ha demostrado una distribución geográfica y étnica de las infecciones causadas por estos virus, las cuales, a su vez, se excluyen mutuamente. También se ha descrito que varios grupos nativos de América presentan una alta prevalencia de marcadores serológicos de esta infección.
Objetivo. Este estudio fue realizado con el propósito de investigar la relación existente entre la infección producida por el virus HTLV-I/II y el polimorfismo genómico de los antígenos de leucocitos humanos (HLA) clase I y clase II en tres diferentes grupos étnicos del litoral norte colombiano: wayúus (amerindios que habitan la península de La Guajira), afrocolombianos (habitantes de los corregimientos Palenque y Barú, de la misma área geográfica colombiana) y mestizos de la ciudad de Barranquilla.
Métodos. La tipificación alélica de los antígenos HLA clase II se llevó a cabo en 41, 75 y 100 muestras de ADN pertenecientes a individuos no relacionados genéticamente, de cada grupo étnico wayúu, mestizo y afrocolombiano, respectivamente, usando la metodología PCR-SSOP. Los alelos HLA clase I se identificaron mediante la metodología PCR-SSOP.
Resultados. Las muestras pertenecientes a los mestizos y a los afrocolombianos resultaron negativas. Once sueros de la población wayúu fueron repetidamente reactivos con aglutinación pasiva (PA) y microELISA (EIA), reconfirmadas usando una prueba de Western Blot (HTLV-Blot, 2.4 Gene Laboratory), y se obtuvo una seroprevalencia al HTLV-II del 7% entre los wayúu. Los alelos con mayor frecuencia en los wayúu fueron DRB10411 (46%) y DQB10302 (83%). Analizando los haplotipos en los 11 wayúu seropositivos encontramos en todos ellos la expresión del haplotipo HLA DRB10411-DQB10302 (p<0.05). Ninguno de los 75 mestizos y los 150 afrocolombianos lo expresaron.
Para los antígenos HLA-Clase I, la muestra estuvo representada por 50 ADN de afrocolombianos no relacionados genéticamente; para ello se utilizó la técnica PCR-SSOP. Los siguientes alelos fueron los más frecuentemente expresados: HLA-A02, A2301, A68011/12/02, A3001, CW0302, C0303, CW04 y CW08.
Conclusiones. Los resultados obtenidos sugieren una restricción genética de la susceptibilidad a ser infectado por este virus y podrían explicar la distribución geográfica y étnica de la infección causada por HTLV-II en estos grupos estudiados.
Hibridização e Educação 4.0 – Perspectivas para o Futuro da EaD
Authors: Dias Danilo Augusto , Mill Daniel
Published: August 2024

Ao analisarmos as perspectivas futuras para a educação a distância, compreendemos que o cenário que se apresenta é o de uma convergência desta modalidade educativa com a educação presencial resultando num processo de educação híbrida. Este ensaio se propõe a uma discussão da educação híbrida como novo campo educativo, criador de novas oportunidades de ensino e aprendizagem mais flexíveis e personalizadas. Por meio de uma discussão teórica, buscamos apresentar conceitos que conectam essa abordagem metodológica aos princípios da chamada Educação 4.0, que se caracteriza pela incorporação das tecnologias da 4ª Revolução Industrial ao processo educativo. Assim, concluímos que a Educação 4.0 é uma proposta que integra plenamente a educação híbrida, sendo uma tendência para o futuro próximo, bem como cria novos espaços que expandem as possibilidades para a aquisição do conhecimento ao longo da vida do indivíduo. 
 
Palavras-chave: Educação híbrida. Educação 4.0. Futuro da educação.
Exploring the Antiviral Potential of Polyphenols against Re-emerging and Emerging Viral Infections: A Comprehensive Review
Authors: Orosco Fredmoore L. , Dapar Mark Lloyd G.
Published: August 2024

The emergence and re-emergence of viral diseases pose significant challenges to global public health. Polyphenols have emerged as promising candidates in the search for effective antiviral strategies because of their diverse biological activities and natural abundance. This comprehensive review aims to provide a detailed analysis of the antiviral potential of polyphenols against a spectrum of viral pathogens. The molecular mechanisms underlying the antiviral activity of polyphenols against coronaviruses, herpesviruses, hepatitis viruses, influenza viruses and noroviruses were thoroughly discussed. Several insights into their general characteristics, extraction methods and general health benefits were also provided. This was followed by an examination of the efficacy of polyphenols as antiviral agents in animal studies and clinical trials. Finally, the promising use of biocompatible nanocarriers was explored to enhance the bioactivity and bioavailability of polyphenols. Despite the progress made in understanding the antiviral activities of polyphenols, several research gaps warrant further investigation. Overall, this knowledge can guide future research and development efforts toward the utilisation of polyphenols as effective therapeutics against a broad range of viral pathogens.
Impact of Engineered Metallic Nano-Oxides on the Growth and Development of Medicinal Crop Carthamus tinctorious L
Authors: Rana Anupriya , Sharma Asha , Kapoor Neha , Sharma Gaurav
Published: August 2024

Background: Nanotechnology has proved itself as a constructive as well as destructive step in the fields of medicine, agriculture, biosciences, pharmacology and engineering in the past three decades. As technology advances, so do diseases and other diverse inflammatory ailments in the modern world. Our daily health comes from the agricultural fields and surroundings. The increased metal toxicity and soil infertility are major causes of concern. Aim: This study aimed to analyse the growth requirements and impact of engineered metallic nano-oxide on the growth of a medicinal oil crop safflower (NARI -96) in a different but favourable geographical area (Rajasthan, India), unusual from its native geographical conditions. The major motive behind this study is to analyse the impact of metallic stress on yield and increase the crop production rate in Rajasthan for medicinal and economic benefit. Methods: The effect of discrete nano-oxides like silver, zinc, titanium and copper oxide with concentrations ranging from 00ppm to 80ppm have been evaluated on Carthamus tinctorius L. The study was conducted in a controlled environment in a Plant Tissue Culture (PTC) lab as well as in greenhouse conditions. Results: The foremost results in the PTC method have been found with the treatment of copper and zinc oxide. The silver oxide showed a toxic effect and retard the growth. The plant growth under normal environmental conditions showed different results due to the alkaline nature of the soil. The efficiency of titanium oxide and copper oxide has been showing better morphophysiological results in comparison to the control and other nano-oxides. Conclusion: The study reveals that metallic nano-oxides greatly influence the growth and development of safflower under controlled as well as in greenhouse conditions but the impact of copper oxide remains constant in both conditions.
ASSESSMENT OF MORPHOMETRIC FEATURES OF THE TOPICAL AND MORPHOLOGICAL LOCATION OF PERMANENT THIRD MOLARS AT DISTAL RELATIONSHIP OF COMPLETE DENTAL ARCHES ACCORDING TO DATA OF ADVANCED CONE-BEAM COMPUTED TOMOGRAPHY
Authors: Grigorenko Mark , Vakushina Elena , Bragin Evgeniy , Lapina Natalia , Mrikaeva Madina , Arzumanyan Lolita
Published: August 2024

Objective. To evaluate the morphometric features of the topical and morphological location of permanent third molars and the possibility of personalized prediction of their eruption, to determine indications for removal using precision data from extended cone-beam computed tomography.
Methodology. 134 patients aged 17–35 years diagnosed with distal occlusion underwent extended cone beam computed tomography. In the program interface, the features of the location of permanent third molars were visualized using panoramic reformats and modernized methods were used to predict their eruption by constructing internal angles. Based on the results of the analysis, recommendations were made for the removal of individual teeth.
Results. On panoramic CBCT \-scans of the upper jaw we visualized 162 1.8 and 2.8 teeth (100%), of which 45 were in retention (27.78 ± 3.52%) and 117 were impacted (72.22 ± 3.52%). Normal parameters of internal angles greater than 90° were determined for 135 1.8 and 2.8 teeth (83.33 ± 2.93%). Abnormal parameters of internal angles less than 90° were determined for 27 1.8 and 2.8 teeth (16.67 ± 2.93%). Diagnostic CBCT-scans of the lower jaw visualized 211 3.8 and 4.8 teeth (100%), of which 77 were in retention (36.49 ± 3.31%) and 134 were impacted (63.51 ± 3.31%). Normal parameters of internal angles greater than 70° were determined for 31 3.8 and 4.8 teeth (14.69 ± 2.44%). Abnormal parameters of internal angles less than 70° were determined for 180 3.8 and 4.8 teeth (85.31 ± 2.44%). To prevent the development of pathology, all teeth with abnormal parameters of internal eruption angles were removed.
Conclusion. Extended CBCT allowed us to visualize retended and impacted permanent third molars on both jaws, analyze the features of their topical and morphological location and determine indications for the individual teeth removal.
MODERN METHODS OF PERMANENT SPLINTING OF MOVABLE TEETH, MATERIALS, METHODS, INDICATIONS AND CONTRAINDICATIONS
Authors: Miroshnichenko Viktoriya , Salimova Nelli , Davtyan Sergey , Yusupova Luiza
Published: August 2024

Subject. The issue of fixing movable teeth in periodontitis with splints remains relevant in dentistry, Dentists face certain difficulties in implementing a comprehensive periodontitis treatment plan. They are faced with the task of eliminating occlusive injury, preserving teeth and, accordingly, improving the quality of life of patients. The difficulties lie in choosing the appropriate design, technique and material of the tire. The complications that patients have to face after the polishing are chips, fractures, hydrophilicity of the tire, poor adhesion. The materials used for splinting are widely represented in the domestic and foreign markets. All of them are different in chemical composition and properties. However, their comparative characteristics have not been fully studied. The problem of studying the properties of splinting materials requires further research.
Purpose. To analyze the modern scientific literature and consider the materials and methods used for splinting movable teeth.
Methodology. The search and analysis of modern special scientific and methodological literature was carried out using scientific search library databases PubMed, Elibrary, Elsveir. The basis for the literature review was 35 sources published between 2017 and 2024.
Conclusions. The types of splinting structures and the properties of the materials from which the tires are made are insufficiently covered in the literature and require our further study and structuring to develop tactics and criteria for choosing a tire based on a specific clinical situation. Compliance with the requirements will help reduce the risk of debonding and tire breakdowns, and a good level of compensation for chewing loads. The absence of breakages, good fit, and polishability will contribute to low bacterial adhesion, which will lead to a more stable remission of periodontitis.
Positive correlation between Bax and Bcl-2 gene polymorphisms with the risk of endometriosis: A case-control study
Authors: Kharrazi Arefe Edalatian , Forghani Forough , Jahantigh Danial , Zidanloo Saeedeh Ghazaey , Rezaei Mahnaz , Taheri Mohsen
Published: August 2024

Background: Endometriosis is a chronic, gynecological disorder, and the disease’s pathogenesis is still debatable. Genes related to apoptosis have been revealed to be deregulated in endometriosis.
Objective: This study investigates the relationship between polymorphic variants of Bax -248G>A and Bcl-2 -938C>A promoter regions with endometriosis risk in an Iranian population.
Materials and Methods: In this case-control study, the polymorphisms of Bax -248G>A and Bcl-2 -938C>A promoter regions were analyzed in 127 Iranian cases and 125 controls who were referred to Ali-ibn-Abi Taleb Educational hospital, Zahedan, Iran between May 2022 and February 2023. The genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method.
Results: The frequencies of mutant allele A carriers and the A allele of Bax -248G>A polymorphism showed about 2-fold significant increase of endometriosis risk (p = 0.04; p = 0.01, respectively). The frequencies of the mutant genotype AA and A allele carriers of Bcl-2 -938C>A polymorphism were approximately 4 and 2.5-fold higher in endometriosis compared to the control women, which were highly significant (p > 0.001). Moreover, the allele A frequency of Bcl-2 -938C>A was associated with a 2-fold higher risk of endometriosis (p > 0.001). Furthermore, the combination effects of these 2 single nucleotide polymorphisms showed that women with Bax -248G>A GG and Bcl-2 -938C>A AA variant alleles were associated with about 5 times higher risk of endometriosis (p > 0.001). Notably, a significant difference was observed in mutant allele distribution between minimal/mild (stage I and II) and moderate/severe (stage III and IV) women with endometriosis disease.
Conclusion: The results of our study provide evidence that Bcl-2 -938C>A and Bax -248G>A single nucleotide polymorphisms might be associated with the risk of endometriosis.
Key words: Endometriosis, Apoptosis, Genetic polymorphism, Bax, Bcl-2.
Sickle Cell Disease Pain and Zinc, Any Link? A Case-Control Study among Patients With Sickle Cell Disease In Korle-Bu
Authors: Ababio Grace , Ababio Boateng Lawrence , Asare Eugenia V. , Reeks Robert , Dongdem Anthony
Published: August 2024

Background: Over some few decades, markers of pain have been studied, of which some trace elements are of no exception. Yet, there is paucity of data on trace elements in SCD pain. Here, zinc levels and its relation to SCD vaso-occlusive pain was shown.
Aim: To determine [zinc] and its relation to pain in sickle cell disease patients.
Methodology: The case-control study was located at the Ghana Institute of Clinical Genetics (sickle cell clinic). After obtaining ethical clearance from College of Health Sciences (CHS-Et/M.1-P5.12/2023-2024), a validated pain assessment questionnaires were used for data collection. Ten (10) mls of blood was collected, six (6) mL was placed in a serum separating tube (SST) for the determination of zinc and four (4) mL into EDTA tube for full blood count and Hemoglobinopathy on cellulose acetate electrophoresis. The data analysis was done using the Statistical Package for the Social Science (SPSS) version 21 and Microsoft Excel 2016.
Results: Average zinc levels for the entire SCD VOC, was 2.569±1.073(39) and this was relatively low during comparison. [Zn] in SCD subjects who consume alcohol yielded p – value of 0.0001 while in patients experiencing VOC had a p-value = 0.000. The odds ratio for zinc exposure seemed to have protective effect on sickle cell disease either in steady state or vaso-occlusive state. [Zn] stratifications also related statistically to blood pressure readings, SCD pain, hemoglobin, red blood cells, white blood cells, platelets and body mass index. Conclusion: The average [Zn] in SCD individuals experiencing VOC was relatively low (p-value = 0.000
Conceptual Approaches to Determining the Level of Effectiveness of Constitutional and Legal Norms
Authors: Godovanik Evgeny V. ,   Professor of the Department of Constitutional and Administrative Law, Putrenko Andrey N. ,   Deputy Director of the Law Institute of the Sevastopol State University, PhD (Law)
Published: August 2024

The work is devoted to the disclosure and comprehensive comparison of the content of conceptual approaches to determining the level of effectiveness of constitutional law norms. Various doctrinal views on the concept of ‘efficiency’ in the social sciences are considered, various models of perception of existing approaches in the constitutional law plane are proposed. The authors formulated theoretical, methodological and scientific and practical conclusions about the applicable criteria and indicators that allow to form an effective model for the implementation of constitutional law norms in specific constitutional law relations. In addition, an attempt was made to systematize the conceptual foundations for determining the effectiveness of the functioning of the entire legal system of the state, the basic social relations within which are regulated by constitutional law norms as prescriptions of higher legal force.
Current Peculiarities of Legislation in the Field of Prosecution of Users for Publishing on the Internet
Authors: Isakova Valentina S. ,   Expert of the Scientific Center of the Nizhny Novgorod Institute of Management
Published: August 2024

The article examines a specific category of crimes and offenses in the field of information dissemination. A consistent review of statistical and empirical data on holding users accountable for expressing opinions on the Internet, the processes of adopting legislative acts that directly affect the increase in the number of administrative and criminal cases, allow us to draw the following conclusions: a) currently there is a situation of unprecedented control by the state authorities over the Russian information space and b) legislation of 2020–2023 introducing new types of administrative and criminal liability for expressing opinions on the Internet, it has the character of ‘extraordinary lawmaking’.
Notarization of Inheritance Rights to the Property of a Production Cooperative (Artel) Member by a Notary
Authors: Zaypulaeva Tamara M. ,   Postgraduate Student of the Department of Advocacy of the Kutafin Moscow State Law University
Published: August 2024

The article considers theoretical and practical problems related to inheritance of property of a member of a production cooperative. The author studies the legal nature of production cooperatives, defines the role of cooperatives in modern conditions of development of market economy. The author analyses the composition of the inheritance in the event of death of a member of a production cooperative and identifies contradictions that arise in the law enforcement practice when transferring a share in the order of hereditary succession. The article provides a list of documents necessary for notary to issue inheritance rights to the property of a member of a production cooperative. The author analyzes the algorithm of actions of the heir after receiving the certificate of the right to inheritance, including the procedure of acceptance of the successor into the members of the production cooperative.
Religious Reforms by P.A. Stolypin and the Principle of Freedom of Conscience in the Activities of the State Duma of the Russian Empire in the Early Twentieth Century
Authors: Koshmar Aleksey V. ,   Postgraduate Student of the Department of Theory and History of State and Law of the Belgorod University
Published: August 2024

The article examines the political activities of P.A. Stolypin, as well as the activities of the State Duma in the spiritual and ethnic spheres at the beginning of the twentieth century. A number of objective factors at the turn of the century practically forced political figures to affirm the principle of freedom of conscience. In this regard, P.A. Stolypin decided to carry out a series of religious reforms, the key result of which anticipated the creation of a political nation. The article indicates the opinions of representatives of different ideologies regarding the activities of P.A. Stolypin, and also analyzed the activities of the State Duma as part of the implementation of religious reforms.
The Interaction Between Guardianship and Custodianship Agencies and State and Municipal Institutions (Organizations) for Orphans and Abandoned Children
Authors: Karpova Olesya A. ,   Postgraduate Student of the Kemerovo State University, Legal Counsel of Youth Recreation Facility
Published: August 2024

The scientific article examines the problems of interdepartmental interaction of guardianship and guardianship authorities with institutions (organizations) for orphans and departments of various directions, whose activities are related to the activities of such institutions. Proposals are increasingly being made to reform the guardianship authorities and institutions for orphaned children by bringing them to a single model of subordination. Such proposals, as well as cases of negligence by employees of institutions and guardianship authorities, which caused a wide public outcry, were the beginning of a global process of restructuring the child protection system in our state. In view of the policy pursued by the RF in this area, deinstitutionalization as part of the reform of these institutions, the author reveals the existing problems of interdepartmental interaction; separately highlights the role of guardianship and guardianship authorities, suggests possible solutions to some problems by amending the legislation of the subjects of the RF.
Bribery Combating in Russia and Abroad
Authors: Petrova Galina O. ,   Professor of the Department of Criminal and Criminal Procedure Law of the Law Faculty
Published: August 2024

The article is devoted to one of the features of the development of mankind — bribery. In the article, we will consider not only the current, but also the previously existing criminal legislation on bribery, using dialectical, historical, comparative and other methods for this purpose. Bribery is prohibited by criminal law, both in Russia and in foreign countries. Let us note the general and differing provisions on the understanding of bribery, punishment for it. Analyzing the legislation, the available opinions of scientists, the author makes suggestions for improving the current criminal legislation on bribery and its application.
Prison Inspection as an Instrument of a ‘New Model’ in the Prison Administration System: The General and Special (1890 to 1917)
Authors: Alekseev Vasily I. ,   Associate Professor, PhD (History), Police Colonel
Published: August 2024

In article key questions of education and activity of provincial prison inspection are considered. Organizational legal support of her activity has allowed to improve legal, moral impact on convicts, protection and supervision in places of detention. Characteristic of prison inspection consists that the new subject of management on average a control link at the provincial level has been formed.
Critical thinking and EAP writing in the context of Iran
Authors: Elhambakhsh Seyedeh Elham , Neysani Masoud , Nikbakht Ahmadreza
Published: August 2024

Some of the fundamental abilities that universities want their students to cultivate throughout their degree programs include critical thinking. By undertaking a meta-synthesis of prior empirical research, this study aims to comprehend how EAP students and teachers interpret critical thinking and which instructional approaches seem to be most successful in teaching both writing and critical thinking. The analysis of nine articles was done by using an operational method to teach critical thinking. The findings indicate that many students in the study continue to have misconceptions about what critical thinking is, and because of these misconceptions or cultural differences, they might be perceived as lacking the will to think critically. Evaluation and synthesis abilities are emphasized in writing teaching because they are seen to be directly related to critical thinking. The data also suggests that persistent cooperative learning could be advantageous to effectively educate critical thinking and writing.
Keywords: Argument; critical thinking; EFL Learners; English language teaching; writing.