bluuebunny/crossref_metadata_2025 huggingface dataset:
Integração de esforços de servidores da área de contabilidade em um Instituto Federal de Ensino baseado no BPM
Authors: Silva Umbelino de Farias Ítalo Filipe , Machado de Medeiros Marcos Fernando
Published: June 2023

Fluxos processuais que eram considerados inviáveis devido ao custo elevado e o tempo que seria despendido com a tramitação física do processo, agora podem ser viabilizados, tendo em vista a implantação do formato digital por algumas instituições e órgãos públicos. Existem modelos de gestão, como o Business Process Management (BPM), que podem alinhar os benefícios proporcionados pela implantação dos processos digitais às demandas da instituição. Nessa perspectiva, este estudo buscou verificar a possibilidade de integração de esforços de servidores da área de contabilidade, responsáveis pelas atividades de emissão de empenho, liquidação e pagamento, em dois CAMPI de um Instituto Federal de Ensino (IFE). Metodologicamente, o estudo tem natureza aplicada, abordagem qualitativa, objetivo descritivo e foi caracterizado como pesquisa-ação. Conduziu-se a pesquisa com base no ciclo de vida de BPM proposto por Baldam (2008), desenvolvendo-se em quatro etapas: seleção e priorização do processo, modelagem do estado atual (as is), modelagem do estado futuro (to be) e execução das atividades com o modelo proposto. De posse das informações levantadas e das representações gráficas dos modelos, elaborou-se um manual para orientar a execução das atividades com o modelo proposto. Os resultados demonstraram que, em termos de sistemas de Tecnologia da Informação e Comunicação (TIC) utilizados durante à execução das referidas atividades, já é possível um servidor da área de contabilidade operacionalizar as demandas para variados CAMPI de um IFE, demonstrando exequibilidade do modelo proposto e aplicabilidade dos conceitos de BPM.
Contribuições das práticas adaptativas de gerenciamento de projetos aplicadas em autarquia pública: o caso do sistema do Plano de Trabalho para Internacionalização (PTI) da CAPES
Authors: Maccari Emerson Antonio , Penha Renato , Sampaio Castro de Oliveira Milton
Published: June 2023

A transformação digital envolve mudanças culturais, tecnológicas e na forma como as organizações trabalham e entregam valor aos clientes. Para tanto, se faz necessário repensar as estratégias organizacionais e assumir novos riscos. Essas mudanças acontecem nos mais diversos ramos da sociedade e, a gestão de projetos impacta na dinâmica das organizações, possibilitando que novas tecnologias, inovações e transformações sejam realizadas de maneira mais efetiva. O objetivo deste relato técnico foi explicitar as contribuições do uso de metodologias adaptativas de gerenciamento de projetos, na gestão e nos projetos da diretoria de tecnologia da informação, da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES. Foi utilizado o método de pesquisa qualitativa, por meio de técnicas de pesquisa documental. Os resultados obtidos na construção do sistema, utilizando devidamente as cerimônias das práticas ágeis, aliado ao comprometimento das partes interessadas e conhecimento do Product Owner – PO, permitiram ratificar a contribuição do uso de metodologias ágeis, no atingimento dos objetivos de um projeto de desenvolvimento de sistemas, na administração pública federal. O que resultou no sistema PTI, e este apoiou a avaliação da execução dos projetos de internacionalização das instituições participantes do edital CAPES/PRINT.
Model Komunikasi Interpersonal Terhadap Kepuasan Kerja pada PT. Anugrah Makmur Indonesia di Tangerang
Authors: Saputra Dadan , Achmad Asep Zulkifli
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh komunikasi interpersonal terhadap kepuasan kerja pada PT Anugrah Makmur Indonesia di Tangerang. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 55 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini variabel komunikasi interpersonal diperoleh rata-rata skor sebesar 3,75 dengan kriteria baik. Variabel kepuasan kerja diperoleh rata-rata skor sebesar 3,87 dengan kriteria baik. Komunikasi interpersonal berpengaruh signifikan terhadap kepuasan kerja  dengan persamaan regresi Y = 11,161 + 0,735X, dan nilai korelasi sebesar 0,786 atau memiliki tingkat hubungan yang kuat dengan kontribusi pengaruh sebesar 61,8% serta uji  hipotesis diperoleh sig. 0,000 < 0,05.
Una revisión bibliográfica sobre métodos de detección de coliformes en fuentes de agua: Avances recientes a nivel internacional
Authors: Jara-Vilca Rocio
Published: June 2023

El consumo de agua contaminada, especialmente por coliformes totales causa múltiples enfermedades intestinales, siendo en la actualidad un problema latente. En ese sentido, el objetivo de la investigación fue analizar los métodos de detección para el análisis microbiológico de agua a nivel internacional. La revisión bibliográfica se realizó en base a datos de Centro Nacional para la Información Biotecnológica (NCBI), Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS) y Scopus, desde el año 2012 a diciembre del 2022. El análisis de datos, se realizó de acuerdo a los artículos seleccionados y a su procedencia. Las redes de coautoría se realizaron con el software VOSviewer. Los resultados muestran que los estudios basados en métodos de análisis de calidad de agua empezaron a sobresalir durante los años 2021 y el País donde se desarrolló con mayor énfasis la investigación fue Estados Unidos. Se concluye que los métodos moleculares son una buena alternativa para análisis de calidad de agua, porque son rápidos y específicos.
Sztuczna inteligencja i przestpczo przyszoci w kontekcie kryminalistycznych bada informatycznych
Authors: Olber Paweł
Published: June 2023

Celem przedmiotowego artykuu jest omwienie roli, zada i wyzwa informatyki kryminalistycznej w kontekcie rozwoju przestpczoci wspartej sztuczn inteligencj. Zagadnienia opisane w artykule bazuj na potencjalnych zagroeniach w przyszoci, ktre zostay zidentyfikowane jako najbardziej uciliwe dla spoeczestwa. Rozwaania zawarte w artykule poprzedzono analiz krytyczn dotychczasowych bada z zakresu sztucznej inteligencji i informatyki kryminalistycznej. Przeprowadzona analiza literatury pozwala twierdzi, e przyszoci kryminalistycznych bada informatycznych jest automatyzacja oparta o algorytmy uczenia maszynowego. Stwierdzono take, e rozwj sztucznej inteligencji bdzie definiowa nowe obszary kryminalistycznych bada informatycznych, uwzgldniajcych analizy modeli sieci neuronowych i zbiorw danych uczcych.
METHODOLOGY FOR IDENTIFICATION OF TRACES OF EXPLOSIVE MATERIALS AND THEIR DERIVATIVES IN COMPLEX MATRIXES ILLUSTRATED BY ACCUMULATION BIOMARKERS
Authors: BARAN Piotr A. , MAZUR Izabela , KASPRZAK Piotr , MODZELEWSKI Damian , TSZYDEL Mariusz , BŁOŃSKA Dagmara
Published: June 2023

Different political and social events of the 21th century have been bringing about the appearance of new threats connected with production, storing and using of combat assets containing the high explosive materials. The contaminations are challenging for specialised laboratories dealing with their detection and identification of sources of origin. Unfortunately, such contaminations have a serious influence into the human health causing for instance significant injuries of human systems and organs, and long term problems with the health such as cancer diseases and other serious health disturbances. Therefore, it is important to focus attention on these threats, and to do everything possible to prevent their appearance and minimise the harmful effects. A low concentration of tested agent, below the instrument detection threshold, is a frequent problem at investigations of ecosystems. In such cases biomarkers of cumulation prove to be very helpful. Biomarkers can be a perfect tool for detection of contaminations in the flowing water and in the ground. They can be used to establish the presence of specific chemical agents and at the same time they are a sensitive indicator of ecosystems reaction to the contamination. A universal method was developed basing on the liquid chromatography for analysis of trotyl and its derivatives present in larvae of caddisflies from species of Hydropsyche angustipennis, Curtis 1834, and in the samples of soil, or in other complex matrixes. The chromatographic method can label quantitively and qualitatively different derivatives of trotyl, such as 2,6-diamino-4-nitrotoluene, 2,4-dia-mino-6-nitrotoluene, 1,3,5-trinitrobenzen, trinitrotoluene, 2-amino-4,6-dinitrotoluen, 4-amino-2,6-dinitrotoluen, and tetryl in a complex biologic matrix. Additionally, an effect was investigated of trotyl cumulation within 1 to 24 hours in the tissue of caddisfly larvae subjected to exposition of tested solutions contained trotyl. An effect of saturation was noticed and the concentration of trotyl derivatives was measured. Observed effects confirmed the usefulness of chosen larvae as a bioindicator of trotyl contamination accumulation in ecosystem.
SECURITY STANDARD OF THE STATE INFORMATION AND COMMUNICATION INFRASTRUCTURE IN NATIONAL LAW
Authors: CISOWSKA-SAKRAJDA Ewa
Published: June 2023

The article presents the normative standard of security of information and communication infrastructure and the importance of security of this infrastructure for the information security of the state. Its main considerations focuses on the concept of the safety standard of this infrastructure and its components, such as normative requirements for infrastructure security, rules for determining requirements applicable to infrastructure and its interoperability, and principles for the creation, modernization and use of information and communication infrastructure.
Spoeczna odpowiedzialno polskiej suby zdrowia w dobie pandemii COVID-19
Authors: Hryszkiewicz Dominik
Published: June 2023

Suba zdrowia w Polsce od kilkudziesiciu lat jest instytucj znajdujc si w centrum uwagi zarwno rzdzcych, jak i caego spoeczestwa. Powodw takiego zainteresowania jest wiele, poczwszy od aspektu ekonomicznego, koczc na sferze polityki spoecznej pastwa. Niniejszy artyku stanowi spojrzenie na problematyk zdrowotn w kraju z nieco innego punktu widzenia. Zawiera analiz instytucji systemu opieki zdrowotnej w Polsce pod ktem jego wielowymiarowej odpowiedzialnoci spoecznej jako szczeglnego rodzaju zobowiza wobec wszystkich czonkw spoeczestwa. Ukazuje spoeczn odpowiedzialno jako nowoczesne narzdzie zarzdzania wspczesnymi organizacjami, rwnie publicznymi. Opracowanie zawiera ponadto analiz moliwoci zastosowania postulatw koncepcji spoecznej odpowiedzialnoci w procesie zarzdzania sub zdrowia w obszarze bezpieczestwa zdrowotnego. System opieki zdrowotnej w Polsce jest jednym z najwaniejszych strategicznie dla polityki spoecznej pastwa obszarem, ktry w ostatnim czasie zosta poddany zapewne najwikszej prbie w powojennej historii naszego kraju. Coraz czciej wrd praktykw oraz autorw opracowa z zakresu nauk spoecznych spotyka si uywanie pojcia bezpieczestwa zdrowotnego jako zagadnienia stanowicego nieodczny element projektowania strategii bezpieczestwa wewntrznego pastwa. Take pod tym ktem autor analizuje system opieki zdrowotnej jako zbioru instytucji, stanowicych jedno z najwikszych organizacyjne wyzwa zarwno dla efektywnej polityki spoecznej, jak i bezpieczestwa wewntrznego Polski w najbliszych latach
O CÓDIGO DO GOVERNADOR DON JOAQUÍN DE CAÑABERAL Y PONCE NA CARTAGENA DE ÍNDIAS DE 1789: UMA ESTRATÉGIA DE CONTROLE SOBRE OS COSTUMES DE UMA COLÔNIA NO CARIBE
Authors: Moura Milton Araújo
Published: June 2023

Trata-se da estratégia de controlar os costumes na cidade portuária de Cartagena de Indias, uma das mais importantes do Império Espanhol, no final do século XVIII, tal como formulado no Código do Governador Cañaberal y Ponce. O documento se refere a aspectos da vida privada, comunitária e política. Pode-se perceber aí como o domínio da capilaridade social e cultural era importante no contexto da dominação colonial.
Estategias de ahorro y gestión financiera para las pequeñas y medianas empresas
Authors: Juárez Sánchez Luis Mauricio
Published: June 2023

La planeación financiera juega un papel fundamental en el éxito y la sostenibilidad de las pequeñas y medianas empresas (PYME). Al implementar estrategias efectivas de ahorro y gestión financiera, algunas  empresas pueden mejorar su calidad de vida y aumentar las oportunidaes de crecimiento, lo que permitirá asegurar su estabilidad económica a largo plazo. A través de una investigación documental se identificaron diversas estrategias y herramientas financieras que las PYME pueden adoptar para alcanzar sus objetivos y mejorar su nivel de vida,  fortalecer sus posición financiera, aumentar su rentabilidad y asegurar una base sólida para el desarrollo y crecimiento continuo. Estos enfoques incluyen la gestión de ingresos y gastos, la reducción de costos, negociación con proveedores y la optimización de los flujos de efectivo.
Optimalisasi Kurikulum Merdeka Dalam Pendidikan Agama Kristen Pada Era Digital
Authors: Christie Nefvina Agatha
Published: June 2023

The digital era has made it difficult to provide new learning methods, where senior teachers seem reluctant to provide criticism and suggestions. The direction of critical discussion is considered disgusting and impolite, even though this is a form of appreciation for every upheaval of discussion in finding bright ideas for the future. This problem must be handled carefully. This study aims to optimize Christian religious education with the help of an independent curriculum. The digital era, which is known to be difficult, can now be overcome easily with the help of the independent curriculum. This study uses qualitative and then researchers take a descriptive approach based on Bogdan. The results of this study found that on-campus student exchanges have a good effect on Christian schools where Christian religious education is more elegant and relaxed without having to be pressured, judging by the age gap which is not too far away and student coaching must continue in this digital era considered important and the willingness of an independent curriculum to provide a portion that Christian religious education can be conveyed to them as driving teachers and competent students in the field of Christian religious education to convey the knowledge given.
 
Abstrak
Era digital menjadi hal yang menyulitkan untuk memberikan metode-metode pembelajaran yang baru, di mana guru-guru terlihat senior sungkan untuk memberikan kritik dan saran. Arah diskusi yang kritis dianggap sebagai suatu menjijikan dan ketidaksopanan, padahal hal ini menjadi bentuk apreasiasi dari setiap pergolakan diskusi dalam menemukan ide-ide cemerlang untuk masa depan. Permasalahan ini harus diatasi dengan seksama. Penelitian ini bertujuan untuk melakukan optimalisasi Pendidikan agama Kristen dengan bantuan kurilum merdeka. Era digital yang dikenal sulit, kini dapat mudah di atas dengan bantuan-bantuan dari kurikulum merdeka. Penelitian ini menggunakan kualitatif lalu peneliti melakukan pendekatan dekskriptif berdasarkan Bogdan. Hasil dari penelitian ini menemukan bahwa pertukaran mahasiswa dalam kampus memberikan efek yang baik bagi sekolah-sekolah Kristen di mana Pendidikan agama Kristen lebih elegan dibawa dan santai tanpa harus ada tekanan, dilihat dari kesenjangan umur yang tidak terlalu jauh dan pembinaan siswa harus terus dilakukan era digital ini dinilai penting serta kebersediaan kurikulum merdeka memberikan Porsi bahwa Pendidikan agama Kristen dapat disampaikan kepada mereka guru penggerak dan mahasiswa-mahasiswa berkompeten dibidang Pendidikan agama Kristen untuk menyampaikan ilmu-ilmu yang diberikan.
Organ wide toxicological assessment of common edible herbs and their mixtures as used in home remedies
Authors: Wodi Chigeru , Ezaka Ebere , Ukwah Boniface N. , Eze Ukpai A.
Published: June 2023

The use of home remedies for medicinal purposes, most of which are edible plants has continued to be a practice in many homes. However, there has been an increasing report of chronic use with lethal effect. Among the commonly used herbal/ medicinal plants were ginger, garlic and lemon. These were seen to be prevalent across continents with brewing and crude extraction being the most means of consumption. This study investigated the organ wide toxicity of this extract following chronic consumption of crude extract. Twenty-five albino Wister rats, five in each group were used for this experiment. Each animal received 0.5ml/kg body weight of either ginger extract, garlic extract, lemon juice, or a mixture of equal volumes of all three extract (v/v) respectively twice daily for seven (7) days. Statistics were represented as ±SE; P≤0.05 was considered significant. Previous studies have shown that moderate consumption of these medicinal plants were beneficial and have shown no deleterious effect. This study observed no change in the weight of the experimental animals. The weight of the animals continued to increase except for the group that received lemon and the mixture, but these were not significant. It was observed that chronic consumption induced organ wide toxicity to include the liver, kidney, intestinal epithelium, stomach, and pancreas. These were shown to alter tissue architecture and the cell morphology. Packed cell volume was reduced in the lemon and the group that received a combination of all extracts (p=o.03). Blood differentials showed changes in levels. An elevated basophil level was observed in ginger and garlic (p<0.0001; p=0.0006). Monocyte levels increased progressively across each group when compared to the control with the most elevated level seen in the group that received the mixture (p<0.0001). Lymphocyte count was reduced across all the groups that received the extract except for animals that received ginger. This study suggests the application of caution among users of these medicinal plants and continues to draw attention to the need for harmonization and standardization of safe use doses.
Autonomous learning in higher education. Systematic review
Authors: Caballero-Cantu Jose Jeremias , Chavez-Ramirez Edith Delia , Lopez-Almeida Mercedes Evangelina , Inciso-Mendo Edgar Salvador , Méndez Vergaray Juan
Published: June 2023

Introduction: higher education requires new learning scenarios, centered on flexible didactic strategies that allow student autonomy and contribute to their maturity in communicative-research competencies.Objective: various investigations carried out regarding autonomous learning in higher education were analyzed. The research was important because it verified the relationship between autonomy and learning. Methods: qualitative research, systematic review, followed the standards of the PRISMA Declaration; The information was obtained in the Scopus database, in the period 2018 - 2023 following the inclusion and exclusion criteria. For the analysis, 50 articles were selected (31 quantitative, 5 qualitative and 14 mixed). Results: they revealed that autonomous learning is the result of the union of individual or group work, self-motivation, solution strategies, responsibility, empowerment and autonomy on the part of the student together with freedom, empowerment, preparation of didactic material. of the teacher. Conclusion: most of the research emphasizes personal responsibility in the face of a situation and self-direction of learning; however, no study addresses the five dimensions of autonomous learning
A Paratextual Study on English Translations of Three Character Classic
Authors: Zhou Li
Published: June 2023

The paratext is the supplement of the main text as well as the important carrier of information transmission. By means of Gérard Génette’s theory, this paper analyzes and compares the differences between the three English translations of Three Character Classic, and holds that the paratext to a large extent reflects the will of publishers and translators and the paratext is of great significance to the evaluation and transmission of the translations and the translator studies.
Diversity of Fungal Community in Rhizosphere Soil of Tomato with Different Diseases
Authors: Che Zhangbin , Ren Liang , Wang Wenhui
Published: June 2023

As an indispensable part of rhizosphere microorganisms, fungi participate in the processes of soil and rhizosphere element cycle and the degradation of pollutants in soil through self metabolism, and have huge potential in protecting tomato from abiotic and biological stresses. Tomato is one of the main varieties in the global trade of vegetables and fruits. In recent years, the planting area of tomato has continued to expand. The simple and intensive planting combined with high temperature and wet environmental conditions has facilitated the growth and breeding of diseases and pests, which has led to a sharp decline in tomato production. In addition, excessive use of chemicals and fertilizers has led to environmental pollution, which has led to a decline in tomato quality, and has caused huge losses to China’s vegetable economy. In this experiment, the rhizosphere soil of several common tomato diseases was used as research materials, and ITS sequencing was carried out for rhizosphere soil fungi by using high-throughput sequencing analysis. The operational taxon units (OTUs), alpha diversity, beat diversity and community structure were analyzed.
The Effect of Vitamin C and E Supplementation into Drinking Water on Carcass Characteristics, Meat Quality and Intestinal Microflora During Pre-Slaughter Feed Withdrawal in Broiler Chickens
Authors: KAYA Hacer
Published: June 2023

This study investigates the effects of adding vitamin C and E to the drinking water on carcass characteristics, meat quality and intestinal microflora populations in broiler chickens during the 10-h pre-slaughter feed withdrawal (FW) period. As study materials, forty male broilers at the age of 42 days were used. The broilers were randomly divided into four groups: Control (non-vitamin, NV), vitamin C (1000 mg/L, VC), vitamin E (500 mg/L, VE) and vitamin combination (1000 mg/L VC+500 mg/L VE, VCE). In the study, vitamin additions didn’t affect carcass characteristics, visceral weights and the pH values of the digestive system (P>0.05). The addition of VC and VE increased the weight of the Bursa of Fabricius, and the addition of VE increased the weight of thymus (P<0.05). Additions of vitamin decreased tendency of carcass contamination (P<0.01) and increased pH45min and pH24h of thigh meat and pH24h of breast meat (P<0.05, P<0.01, P<0.01, respectively). While a* color intensity of breast and thigh meat increased with all vitamin supplements, L* and b* values of thigh meat decreased (P<0.01). Vitamin supplements, especially VE, reduced the drip loss of breast and thigh meat (P<0.05) and the pathogenic microorganism populations of intestinal contents (P<0.01). As a result, it is thought that the addition of 500 mg/L vitamin E to the drinking water of broiler chickens exposed to the pre-slaughter fasting period will be beneficial to improve meat quality and reduce intestinal pathogenic microorganism load. However, more extensive experimental studies are needed.
Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity
Authors: TAŞKAYA Aylin , CEYHAN GÜVENSEN Nur , GÜLER Cem , ŞANCI Ebru , KARABAY Ülkü
Published: June 2023

Microbial polysaccharides are extracellular polymeric macromolecules excreted in microorganisms. These are widely used in food, cosmetic and pharmaceutical industries. One of them, exopolysaccharides (EPS), plays important role against the factors such as phage attack, antibiotics, toxic compounds or osmotic stress. Recently, this natural polymer has received great attention due to their therapeutic potential. The purpose of the study was to evaluate biological activity and potential toxicity of EPS from Rhodococcus pyridinivorans ZZ47 strain isolated from nature. EPS has no genotoxic effect on Salmonella typhimurium TA98, TA102, and TA1537 strains by Ames Test. No death occurred with single dose oral toxicity test of EPS and LD50 value of it is calculated by >2000 mg/kg in mice. The EPS showed antibiofilm activity on different bacteria. In addition, EPS demonstrated dose-dependent anti-angiogenic properties by HET-CAM test. In conclusion, the isolated EPS has antioxidant activity with no genotoxicity and the biological activities of the polymer indicated that it may be suitable for use in different sectors and industrial applications.
In Bayern wird randaliert: Bayerischer Mundart-Rap in dei G'sicht!
Authors: Warner Julian
Published: June 2023

Der Autor beleuchtet, inwieweit sich Akteure im bayerischen Mundart-Rap hegemonialen Diskursen um Sprache, Repräsentation und Rassismus widersetzen.
EVALUATION OF THE ACTIVITY OF PERIPHERAL BLOOD NATURAL KILLER CELLS IN HEALTHY SUBJECTS AND BREAST CANCER PATIENTS
Authors: Dieu Thuy Chuyen , Phung The Hai , Nguyen Hoang Phuong , Hoang Trung Kien , Nguyen Ngoc Tuan , Nguyen Dang Dung , Do Khac Dai
Published: June 2023

Objectives: To study Natural Killer (NK) cell activity (NK-IFNg) and some indicators related to immunological characteristics of peripheral blood NK cells in healthy people and breast cancer patients. Methods: We evaluated NK cell activity through its secretory characteristics (NK-IFNg) using ATGen's commercial NK VUE TestÒ (ATGen kit) on 35 healthy subjects (medical staff) and 132 cancer patients treated at Vietnam National Cancer Hospital  from August 2020 to February 2023. At the same time, we collected peripheral blood samples to conduct immunological characterization of peripheral blood NK cells based on the flow cytometer system (number, expression of the activation and inhibitory receptors such as NKG2A, NKG2D), and some other biomarkers (CEA, CA 15.3). Results: The secretory activity of peripheral blood NK cells (NKA-IFNγ) in breast cancer patients (1,013.46 ± 1,115.87 pg/mL) was statistically significantly lower than that in the healthy group ( 2,571.38 ± 827.52 pg/mL) ( ± SD) (p < 0.001). The proportion of breast cancer patients with NKA-IFNγ activity of a very low level (≤ 200 pg/mL) was 40.9% and that of the healthy subjects was 0%. There was no relationship between NKA-IFNγ and peripheral blood NK cell count, and the expression levels of the activating receptor NKG2D and the inhibitory receptor NKG2A. Patients with CEA and CA 15.3 serum levels above the normal limits accounted for relatively low percentages (10.6% and 6.1%). Conclusion: Breast cancer patients with very low NK cell activity accounted for a significant proportion (40.9%). NKA-IFNγ activity could be used as a potential tool for monitoring the immune system health status of breast cancer patients before and after receiving treatment interventions.
NGHIÊN CỨU ĐỘC TÍNH CẤP VÀ BÁN TRƯỜNG DIỄN CỦA VIÊN DẠ DÀY 105 TRÊN ĐỘNG VẬT THỰC NGHIỆM
Authors: Nguyễn Tô Hiệu , Hồ Cảnh Hậu , Lê Thị Hồng Hạnh , Lê Thị Huyền Trang
Published: June 2023

Mục tiêu: Xác định được độc tính cấp trên chuột nhắt trắng và bán trường diễn trên chuột cống trắng của Viên Dạ dày 105. Phương pháp nghiên cứu: Sử dụng phương pháp Litchfield - Wilcoxon để đánh giá độc tính cấp trên chuột nhắt trắng. Đánh giá độc tính bán trường diễn của chế phẩm theo quy định OECD và Bộ Y tế Việt Nam trên đối tượng là chuột cống trắng. Kết quả: Với liều cao nhất cho chuột uống là 63,33 g/kg/24h chưa xác định được LD50 của Viên Dạ dày 105 trên chuột nhắt trắng. Chuột cống trắng uống chế phẩm liên tục trong 28 ngày với 2 mức liều 0,67 g/kg/24h và 2,02 g/kg/24h không gây ảnh hưởng đến số lượng hồng cầu, bạch cầu, hàm lượng hemoglobin, hoạt độ enzym AST, ALT, hàm lượng cholesterol, albumin và creatinin, không gây biến đổi về mô bệnh học của tế bào gan, thận trên chuột nghiên cứu. Kết luận: Viên Dạ dày 105 không gây độc tính cấp trên chuột nhắt trắng với liều cao nhất cho chuột uống là: 63,33 g/kg/24h và không ảnh hưởng đến chức năng tạo máu, chức năng gan, thận của chuột cống trắng thí nghiệm sau 28 ngày nghiên cứu.
Implementasi Branding Dan Digital Marketing Untuk Strategi Pemasaran UMKM Di Desa Ngampungan
Authors: Retno Dwi Astutik  , Nurul Aulia Dewi  , Aptania Fairuz Wardani  , Amilia Eka Putri  , Daffa Samdya Adabi Selay  , Mu’tasim Billah
Published: June 2023

Digital marketing is a form of marketing strategy that uses the internet as a link between businesses and consumers. By using the internet, businesses can reach more consumers and expand their market share. The application of digital marketing can increase the level of customer loyalty because the consumer's sense of satisfaction to buy, identify, know the value of goods without leaving the house is fulfilled. This paper was created to describe the implementation of branding and digital marketing that the author has done as a form of community service in the Real Work Lecture program in Ngampungan Village, Bareng District. The research method used in scientific writing is descriptive by describing the activities that have been carried out and their outputs. The author provides assistance to respondents in several aspects, such as socialization regarding branding, making packaging labels, and socializing marketing on several social media platforms.
A Scoping Review of Clinical Research on Motion Style Acupuncture Treatment
Authors: Kim Doori , Lee Yoon Jae , Ha In-Hyuk
Published: June 2023

This scoping review was conducted to examine the concept of Motion style acupuncture treatment (MSAT), use in clinical practice, its effectiveness, and safety. A literature review of clinical study treatment methods combining acupuncture and movement therapy was performed using PubMed. Of 2,096 studies retrieved, 22 were included in this review. There were 12 randomized controlled trials, and all 22 studies were published in China and Korea, mostly, within the last 3 years. There were five studies concerning local acupoints and 17 studies regarding needling at distal acupoints, and the level of risk of the procedure was “high” in eight studies and “moderate” in 14 studies. The study participants were patients with musculoskeletal pain, and many studies reported significant improvements in pain and functional disability outcomes following treatment using MSAT. For conclusion, MSAT refers to a treatment method in which a patient performs active/passive movements under the supervision of a physician with the acupuncture needle retained at the insertion site. However, there are a limited number of MSAT studies, and various treatment types and related terms are mixed. Further studies, classification of the types of MSAT using a well-established classification system, and a clearer definition of the MSAT concept are needed.
Minimum Clinically Important Difference for Nonsurgical Interventions for Spinal Diseases: Choosing the Appropriate Values for an Integrative Medical Approach
Authors: Lee Ye-Seul , Lee Sungmin , Lee Yoon Jae , Ha In-Hyuk
Published: June 2023

The minimal clinically important difference (MCID) plays a crucial role in the design and interpretation of clinical trials, as it helps in distinguishing between statistically significant and clinically meaningful outcomes. This scoping review aims to collate and appraise the current research concerning the validation of MCIDs for surgical and nonsurgical measures for spine disorders. Two databases of MEDLINE (PubMed and EMBASE) were searched. There were 1,590 studies retrieved and 79 were selected as eligible for review. Measurement tools such as the Oswestry Disability Index, Neck Disability Index, Numeric Rating Scale, and Visual Analogue Scale were assessed by regions and interventions. A total of 24 studies identified MCIDs on nonsurgical interventions, and 55 studies identified MCIDs on surgical interventions. The range of MCIDs varied greatly depending on study population, specific interventions, calculation methods, and outcomes. This scoping review emphasizes the complexity and variability in determining MCIDs for musculoskeletal or neurodegenerative spinal diseases, influenced by several factors including the intervention type, measurement tool, patient characteristics, and disease severity. Given the wide range of reported MCIDs, it is crucial to consider the specific context when interpreting these values in clinical and research settings. To select an appropriate MCID value for comparison in a clinical trial, careful consideration of the patient group, intervention, assessment tools, and primary outcomes is necessary to ensure that the chosen MCID aligns with the research question at hand.
ACURATE: A Guide for Reporting Sham Controls in Trials Using Acupuncture
Authors: Lee Ye-Seul , Kim Song-Yi , Lee Hyangsook , Chae Younbyoung , Lee Myeong Soo
Published: June 2023

This paper presents the Acupuncture Controls gUideline for Reporting humAn Trials and Experiments (ACURATE) checklist, an extension of The Consolidated Standards for Reporting of Trials (CONSORT) and to be used along with STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) when both real and sham acupuncture needles are used in the study. This checklist focuses on a clear depiction of sham needling procedures to enhance replicability and enable a precise appraisal. We encourage researchers to use ACURATE in trials and reviews involving sham acupuncture to assist reporting of sham acupuncture procedures and the related components.
Bojungikgi-tang Alleviates Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Macrophages and C57BL/6 Mice
Authors: Kim Hyo In , Han Yohan , Park Jinbong
Published: June 2023

Background: This study evaluated the anti-inflammatory effect of Bojungikgi-tang (BJT) in a model of acute lung injury (ALI) in mice.Methods: Murine cell line macrophages (RAW264.7) were treated with BJT for 30 minutes before lipopolysaccharide (LPS) treatment. The levels of cytokines, mRNAs, proteins, and related markers were investigated. In addition, BJT (200 mg/kg/day) was administered orally to C57BL/6 mice for 2 weeks prior to an intraperitoneal injection with LPS to induce sepsis and ALI; 24 hours post LPS injection, mice were sacrificed and blood was collected from the infraorbital vein. Lung tissue was harvested, hematoxylin and eosin staining was performed, the wet/dry ratio of the lung tissue was measured, and the serum cytokine levels were analyzed.Results: Compared with LPS treatment, BJT suppressed LPS-induced mRNA expression and secretion of inflammatory cytokines in RAW264.7 macrophages. Furthermore, inducible nitric oxide synthase, cyclooxygenase-2, toll-like receptor 4, phosphorylation of mitogenactivated protein kinases, and phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells were inhibited by BJT. In mice, LPS-induced pathological changes in lung tissues, such as abnormal histological structures, immune cell infiltration, and lung edema were less severe following BJT treatment. BJT inhibited the LPS-induced increase of cytokines such as interleukin 4, 6, 10, and tumor necrosis factor alpha.Conclusion: BJT had an inhibitory effect in the pathological progress of LPS-induced sepsis and ALI and may be a promising therapeutic agent in the future.
The Mazzanti AcuOsteo Method®: Pathology and Treatment with Acupuncture and Osteopathy of the Musculoskeletal Pain of The Upper and Lower Limbs
Authors: Mazzanti Umberto
Published: June 2023

Musculoskeletal pain is one of the most frequent reasons for consultations in my clinic. In my experience of 35 years, acupuncture, and osteopathy are effective techniques in the treatment of musculoskeletal pain of the upper and lower limbs. Pain reported by the patient often affects a widespread area around the joint and is usually associated with some stiffness. The aim of acupuncture is to restore the local circulation of Qì and Blood, inducing an analgesic and anti-inflammatory effect, along with myofascial detensioning. The aim of the osteopathic manipulative treatment is to return joints to their normal position and restore restricted joint motion. The Mazzanti AcuOsteo Method is a newly patented method which uses the synergistic combination of using points for acupuncture, cupping or bleeding, and osteopathy to maximize effectiveness of treatment for musculoskeletal pain.
Effectiveness and Safety of Duantengyimu-tang for Rheumatoid Arthritis: A Protocol for a Systematic Review and Meta-Analysis
Authors: Park Gyoungeun , Moon Jeong-Hyun , Kim Eun-Jung , Sung Won-Suk
Published: June 2023

Background: Per-oral pharmacological medication is a representative treatment for rheumatoid arthritis (RA), and has improved over several guidelines. However, limitations of long-term use of these medications including adverse events, led to the introduction and utilization of complementary and alternative treatments for RA. Several herbal medicine decoctions have been reported to be effective and safe; a recent study introduced Duantengyimu-tang (DTYMT). Regardless of the pharmacological effects of the DTYMT components, there are concerns about its safety. Therefore, this systematic review (SR) will focus on the effectiveness and safety of DTYMT treatment for RA.Methods: Searches for randomized controlled trials using DTYMT treatment for RA will be performed using multiple electronic databases, manual searches, and emails (if necessary). A summary will be written using data on outcome measurements of the study participants, interventions, adverse events, and risk of bias in the studies. The primary outcomes will be disease activity scores including effective rate, tender joints, swollen joints, and morning stiffness. The secondary outcomes will include adverse events and blood tests for RA (erythrocyte sedimentation rate, C-reactive protein, and rheumatoid factors). This SR will use Review Manager software to perform a meta-analysis, the Cochrane Collaboration “risk of bias” tool, and determine the quality of evidence using the Grades of Recommendation, Assessment, Development, and Evaluation method.Results: This SR will investigate the clinical effectiveness and safety of DTYMT treatment in patients with RA.Conclusion: This SR aims to be informative for patients and clinicians in clinical practice, researchers, and policymakers in managing RA.
Plataforma de Projeção Interativa para Jogos Sérios Relacionados ao Transtorno do Espectro Autista
Authors: Trindade André B. , Hounsell Marcelo da Silva
Published: June 2023

Este artigo apresenta o desenvolvimento de uma plataforma interativa para a projeção de exergames sérios para crianças com transtorno do espectro autista (TEA). Através do uso de visão computacional e equipamentos convencionais, a plataforma detecta a interação do jogador com o jogo. O jogo foi desenvolvido com a participação de especialistas em TEA, autistas, game designers e engenheiros (total de 42 especialistas) e visa auxiliar o desenvolvimento motor, atenção e memória. Graças à utilização de instrumentos e metodologias disponíveis na literatura, foi possível reunir os requisitos para esta solução. Além disso, uma avaliação com 61 respondentes comprovou a utilidade do resultado do ponto de vista dos especialistas.
Model, Taxonomy and Methodology for Research Employing Electroencephalography-based Brain-Computer Interface Games
Authors: Mendes Gabriel Alves Vasiljevic , Miranda Leonardo Cunha de
Published: June 2023

The thesis summarized in this work presents a model for representing EEG-based BCI games, a taxonomy for classifying and comparing studies of the field, and a methodology for conducting scientific studies using those games. The model is intended to describe and develop new EEG games by instantiating its components. The CoDIS taxonomy considers four aspects of such games: concept, design, implementation and study, each with different dimensions to represent various of their characteristics. Based on the model and the taxonomy, the PIERSE methodology was developed for the planning, implementation, execution and reporting of scientific experiments using those games. The contributions of the thesis are detailed in various dimensions in this manuscript.
An Architectural Framework for Expert Identification Based on Social Network Analysis
Authors: Lopes Tales , Ströele Victor , Braga Regina
Published: June 2023

Este trabalho propõe uma solução para a análise sintática e semântica em redes sociais no contexto do Desenvolvimento Global de Software. Conduzimos três estudos de caso utilizando dados extraídos de GitHub para avaliar a abordagem proposta. Os estudos de caso fornecem indícios de que o nosso método proposto pode identificar especialistas, destacando a sua especialidade e importância para a evolução da rede social.
Elementos de colaboração nos métodos ágeis de desenvolvimento de software
Authors: Stefani Carlos Eduardo , Duduchi Marcelo
Published: June 2023

Este estudo identifica elementos de colaboração nos métodos ágeis de desenvolvimento de software mais usados, agrupa-os e classifica-os em requisitos de colaboração e relaciona-os a requisitos de maturidade em colaboração estabelecidos no ColabMM. Como resultado, encontra 26 grupos de elementos explicitamente presentes nos métodos ágeis estudados e algumas lacunas de cada método em relação aos requisitos de colaboração, além de relações entre os elementos de colaboração dos métodos ágeis e requisitos de maturidade em colaboração.
As Experiências de Estudantes em um Curso de Engenharia de Computação Baseado em PBL
Authors: Cintra Cristiano da S. , Bittencourt Roberto A.
Published: June 2023

Aprendizagem Baseada em Problemas (PBL) é uma metodologia ativa utilizada em todo o mundo, inclusive na área da computação. Porém, apesar de décadas de prática da metodologia em diversos países, inclusive com vários relatos publicados, ainda são poucos os trabalhos que abordam detalhadamente a perspectiva dos estudantes que aprendem com PBL. O objetivo deste estudo foi descrever como os estudantes de um curso de Engenharia de Computação vivenciam a metodologia PBL. Através de uma análise fenomenológica interpretativa, identificamos seis essências na perspectiva deles, as quais fornecem insights valiosos e possibilitam a reflexão sobre os benefícios e desafios de PBL no ensino superior, especialmente na área de computação.
Uso de Metaverso em Avaliações Formativas Híbridas
Authors: Classe Tadeu Moreira de , Castro Ronney Moreira de , Oliveira Eduardo Gomes de , Oliveira Edmar Welington
Published: June 2023

A COVID-19 motivou e acelerou inovações no campo educacional, oportunizando reflexões sobre os benefícios da educação remota e híbrida. As lições aprendidas neste período influenciaram a maneira como os docentes avaliam seus alunos, uma vez que houve grande dificuldade na realização de avaliações somativas tradicionais em ambientes remotos ou híbridos. Neste contexto, este artigo apresenta um estudo que usa metaverso e aprendizagem ativa para dar suporte à avaliações formativas híbridas. A metodologia usada se baseou em survey, sendo as respostas analisadas por métodos qualitativos. Como resultado, observou-se que os alunos perceberam que a avaliação formativa híbrida usando metaverso pode ser uma boa prática, além de considerarem aprender melhor através dela.
Percepções de estudantes de diferentes áreas do conhecimento sobre equipes interdisciplinares no ensino de tecnologias
Authors: Costa Catarina , Nishihira Josana , Souza Maria L. Hall de
Published: June 2023

As contribuições da extensão universitária são relatadas como de grande impacto para a formação em computação. Mas o que acontece nas formações de extensão universitária em computação com alunos de diferentes áreas do conhecimento? Acredita-se que estudantes com diferentes habilidades e conhecimentos podem enriquecer o diálogo sobre problemas cotidianos e suas soluções tecnológicas. Logo, essa pesquisa teve como objetivo investigar as percepções de estudantes, de diferentes áreas do conhecimento, relacionadas às equipes interdisciplinares em um curso envolvendo tecnologias e empreendedorismo. Um total de 67 estudantes, compondo 13 equipes e cursando diferentes graduações, concluíram os cursos do projeto de extensão e 63 responderam ao survey conduzido. Os resultados indicam que as percepções dos estudantes foram muito positiva, com destaque à troca de experiência e conhecimento.
Uma Análise Retrospectiva dos Cursos Ofertados pelo LearningLab para Auxiliar na Formação Acadêmica dos Estudantes de Computação
Authors: Rocha Marina , Chaaban Pedro C. , Silva Jordas Felipe , Lima Israely , Alves Aline , Rabelo Jacilane de H.
Published: June 2023

O ensino de Computação utilizando métodos mais interativos vem sendo cada vez mais frequente. O estudo realizado neste artigo tem como finalidade documentar a série de cursos ofertados pelo projeto LearningLab aos estudantes do Campus Russas da Universidade Federal do Ceará (UFC) com o objetivo de expandir conhecimento e capacitar alunos para o mercado de trabalho. Para tal propósito, levantou-se um conjunto de dados referentes a diferentes aspectos dos cursos a partir de formulários Google Forms, os quais foram analisados de forma quantitativa e qualitativa. Logo, a partir do feedback de 200 alunos foi possível evidenciar semelhanças e diferenças na realização de diferentes cursos, e a contribuição na formação acadêmica dos estudantes, o que trouxe um panorama geral de alta qualidade dos serviços prestados pelo projeto.
Cognição através da Robótica Educacional: Perspectivas no desenvolvimento das Ciências
Authors: Barreto Ana Lúcia de O. , Boente Alexandre dos S. , Rosa Paulo Fernando F.
Published: June 2023

Este trabalho apresenta um relato de experiência baseado no ensino híbrido, utilizando a Robótica Educacional na formação acadêmica de um grupo de alunos do Ensino Médio na Educação Básica. Para o desenvolvimento do trabalho, utilizaram-se o simulador Tinkercad, o Ambiente Virtual de Aprendizagem – Moodle, a plataforma de prototipagem Arduino, Lego MindStorm Education e o aplicativo Google Sites para postagem do portfólio personalizado do discente, desenvolvido ao longo dos encontros para vivificar e registrar os seus projetos. Ao final, pôde-se verificar que a estratégia utilizada se mostrou eficaz no desenvolvimento de habilidades e competências necessárias para que esse jovem experiencie projetos de vida e fortaleça sua formação acadêmica.
Kants Konzeption des höchsten Gutes
Authors: Hahmann Andree
Published: June 2023

Kant’s highest good consists of happiness and the worthiness of happiness, that is, morality. The question of the exact connection between these two parts is disputed. Some argue that Kant proposed different, sometimes contradictory, concepts of the highest good. First, the highest good is said to consist in the distribution of happiness in relation to morality. Second, the highest good is said to describe a maximal or best state in which the greatest morality is associated with the highest happiness. This paper will show how the problematic relationship between the two elements of the highest good can be resolved and explain the different versions of the highest good.
Chronic Postoperative Pain
Authors: Gilberto Almeida-Návar Saúl , Reyes-Sampieri Nexaí , Trinidad Morelos-Garcia Jose , Mario Antolinez-Motta Jorge , Ivan Herrejón-Galaviz Gabriel
Published: June 2023

Understanding the definition of pain has imposed numerous challenges toward pain practitioners. The pain experience phenomena are complicated to understand, and this construct goes beyond biomedical approaches. Persistent pain as a disease implicates changes that include modified sensory feedback within the somatosensory system. It has been documented that different anatomical restructuring in nociceptive integration and adaptations in nociceptive primary afferents and perception conduits are present in persistent pain situations. Chronic postoperative pain (CPOP) is known as a particular disorder, not only associated with a specific nerve damage or manifestation of a unique inflammatory response but also with a mixture of both. The occurrence of CPOP varies substantially among the literature and depends on the kind of procedure. There are reports informing that 10 to 50% of the patients undergoing common procedures had CPOP, and 2 to 10% of patients complained of severe pain. Systematic review has been performed trying to identify the Holy Grail, none showed sufficient evidence to guide CPOP treatment, and multimodal approaches must be tried in large randomized controlled trials (RCTs) to provide robust evidence as evidence-based management for CPOP still lacking.