bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMASARAN KOPI SECARA DIGITAL DAN STRATEGI BISNIS DALAM PANDEMI COVID-19
Authors:   STMIK LIKMI BANDUNG, Dharmawan William
Published: July 2022

Indonesia is located in a geographical area, therefore many areas are used as coffee plantation land. Coffee in Indonesia has a rapid economic impact, it is proven that the number of coffee shop businesses in the cityof Bandung is likely to expand. This study was conducted to find out coffee marketing strategies in the midst of the Covid-19 pandemic. The object of this research is a coffee shop that is developing and hit by the pandemic. The business that is focused on this research is Old Ben's Garage and Coffee a business that has a digital markerting model by utilizing social media, and as well as utilizing instant courier delivery. Old Ben's Garage and Coffee also has a website to provide information to consumers.This research uses a qualitative approach with an interpretive paradigm aimed at determining the right marketing strategy. By implementing a 7P marketing mix strategy as well as SWOT (Product, Price, Place, Promotion, people, Physical Evidence, Process). This research shows that Old Ben's Garage and Coffee can survive by optimizing digital marketing strategies during the Pandemic
ANALISIS BEBAN KERJA MELALUI METODE FULL TIME EQUIVALENT UNTUK MENGOPTIMALKAN KINERJA PEGAWAI DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KOTA MADIUN
Authors:   Universitas PGRI Madiun, Injavira Alvissa , Hasanah Karuniawati ,   Universitas PGRI Madiun
Published: July 2022

The purpose of this study is tofind out the large workload obtained by employees and the optimal number of employees needs in each section and field in the Population and Civil Registry Office of Madiun City. This study was conducted on employees of the Population and Civil Registry Office of Madiun City with a sample of 41 respondents. In addition, this study uses the Full Time EquivalentMethod. The result of this study is that employees in the Staffing and General Section have an FTE value of 0.5 (underload) and in the formation only need six employees. Then employees in the Finance Section have an FTE value of 0.5 (underload) and in that section only need two employees. Employees in the Field of Civil Service and Registration have an FTE value of 1.29 (overload) and in that fieldneed to be added two employees. Employees in the Field of Population Registration Services have an FTE value of 1.4 (overload) and need to be added five employees to fill the formation. Employees in the Field of Information Management of Population Administration and Data Utilization have an FTE value of 0.7 (underload) and in that field only need three employees.
DESAIN LAPORAN KEUANGAN BERBASIS MICROSOFT EXCEL PADA TOKO BERKAT
Authors:   Politeknik Negeri Manado, KristianPantow Andreuw , NugrahaTangon Joseph ,   Politeknik Negeri Manado, Nurani Korompis Sintia ,   Politeknik Negeri Manado, Ligia Sae Merry ,   Politeknik Negeri Manado, Maradesa Christony ,   Politeknik Negeri Manado
Published: July 2022

This study aims to design the financial statements of Toko Berkatusing the Microsoft Excel application.The research method was qualitative. Instruments of data collection was down through interview in the form of questions regarding the recording of financial statements.While the data collection instrument with documentation, was done through namely evidence of transactions that occurred in the business. The system for recording financial reports at Toko Berkat is still done manually without using an application, so the accounting recording process is not in accordance with SAK EMKM. The financial reports at Toko Berkat are designed using Microsoft Excel. This research can overcome the problem of recording financial statements at Toko Berkat, although in practice the owner is still assisted by researchers to process financial reports using the system that has been created.
ENGARUH INFORMATION TECHNOLOGY INFRASTRUCTURETERHADAP KNOWLEDGE SHARING INTENTIONDI INDUSTRI RETAIL INDONESIA
Authors:   Universitas Katolik Parahyangan, Leony Johanesputri Violivia , Gunawan Agus ,   Universitas Katolik Parahyangan, Pribadi Kornarius Yoke ,   Universitas Katolik Parahyangan, Caroline Angela ,   Universitas Katolik Parahyangan
Published: July 2022

Covid -19 has forced all industries to adapt in order to survive, especially in the retail industry. The retail industry can adapt if they do knowledge sharing so that all employees have the same knowledge. Retail business need to provide a system that can help distribute knowledge to all employees. This system needs to be supported by technological advancement to accelerate the process of distributing this knowledge. This explanatory type of research aims to determine the relationship and the influence of information technology infrastructure (ITI) variables on knowledge sharing interest (KSI) variables in the Indonesian retail industry. The sampling technique in this research is purposive sampling with a sample of 173 respondents. The results showed that ITI and KSI had a strong relationship, namely 0.690 and an R-square value of 0.476, which means that ITI has apositive and significant effect on KSI
PENGARUH HARGA DAN KUALITAS PRODUK PAKET INTERNET TERHADAP KEPUTUSAN PEMBELIAN KARTU PRABAYAR SIMPATI (STUDI KASUS PADA MAHASIWA PROGRAM STUDI MANAJEMEN UNIVERSITAS SJAKHYAKIRTI PALEMBANG)
Authors:   Universitas Sjakhyakirti, Pebrianti Tutik
Published: July 2022

This study aims to determine: (1) The effect of internet package prices on the decision to purchase a prepaid sympathy card. (2) To determine the effect of internet package product quality on the decision to purchase a prepaid sympathy card. The sample used in this study were students and students of the Management Study Program, Sjakhyakirti University, Palembang. As for the number of respondents as many as 154 respondents, the data was obtained through a questionnaire while the method used in this method sampling was the incidental sampling. The analytical method used is a quantitative method. The analysis technique used in analysis Partial Least Square (PLS)with the help of the SmartPLS version 3. The results of testing the hypothesis show that the variables: (1) the price variable has a significant effect on the purchasing decision variable, as indicated by the t-count value is 2.703, then 2.703 >1 .97 This indicatesthat the t count is greater than the t table, then with a p valueof 0.007, it is found that 0.007 <0.05. (2) The product quality variable has a significant effect on the purchasing decision variable, as indicated by the t-count value is 5.644, then 5.644>1.97. This indicates that the t-count is greater than t-table, with a p valueof 0.000, then 0.000 <0.05
ANALISIS KINERJA KEUANGAN PADA PT. KIMIA FARMA (PERSERO)TBK
Authors:   Manajemen, Universitas Simalungun, Silvira Zega Hani , M. Girsang Rosita ,   Universitas Simalungun, Tarigan Vitryani ,   Universitas Simalungun
Published: July 2022

This study aims to determine and analyze the financial performance of PT. Kimia Farma (Persero) Tbk. The research method used in this study is a quantitative analysis method, namely a research method with objects in the form of numeric data or numbers thatwas carried out for three years of research from 2019 -2021. The population is all financial statements of PT. Kimia Farma (Persero) Tbk, which is listed on the stock exchange. The sample taken is the financial statements in 2019-2021 which are on the stock exchange.The results of this study indicate that the formulation of the problem proposed that the financial performance of PT. Kimia Farma (Persero) Tbk for the period 2019 –2021 is healthy. This means that the 2019-2021 financial statements have a good performance every year.
A new method for obtaining the magnetic shape anisotropy directly from electron tomography images
Authors: Radu Cristian , Vlaicu Ioana D , Kuncser Andrei C
Published: July 2022

A new methodology to obtain magnetic information on magnetic nanoparticle (MNP) systems via electron tomography techniques is reported in this work. The new methodology is implemented in an under-development software package called Magn3t, written in Python and C++. A novel image-filtering technique that reduces the highly undesired diffraction effects in the tomography tilt-series has been also developed in order to increase the reliability of the correlations between morphology and magnetism. Using the Magn3t software, the magnetic shape anisotropy magnitude and direction of magnetite nanoparticles has been extracted for the first time directly from transmission electron tomography.
Przegląd systematyczny literatury – znaczenie i możliwości wykorzystania w obszarze badań dotyczących architektury
Authors: Abramczyk Magdalena , Korbel Wojciech
Published: July 2022

Przegląd systematyczny literatury jest metodą badawczą wykorzystywaną w wielu szybko rozwijających się dziedzinach nauki, czasami początkowym stadium badań. W artykule przeanalizowano popularność i znaczenie tej metody w obszarze badań dotyczących architektury. Podjęto również próbę określenia możliwości jej wykorzystania oraz trudności, które można napotkać przy stosowaniu przeglądu systematycznego literatury w wymienionej dyscyplinie.
FOLDER SYSTEM ORGANIZER USING WEB DEVELOPMENT
Authors:   Computer Science & Engineering, Galgotias University, Greater Noida, India, Tarika Ujjwal , Singh Shubham ,   Computer Science & Engineering, Galgotias University, Greater Noida, India, B Shajahan ,   Computer Science & Engineering, Galgotias University, Greater Noida, India
Published: July 2022

This paper gives an overview of the web technologies. The general idea of the new version of the HTML5, CSS and JS and other tools which is presented in this paper is the formal specifications and the establishment of uniform solutions for technologies and functionalities which have been for the computer users for the easily access of the files storage so that they can make their folder and files easily and by using one extension. The extension use the support of the node js. The structure and styling will be done in the HTML and CSS respectively. The complex features like adding the file or folder in the project will be done by JavaScript(JS). The main aim of this paper is to make have one extension which that will make the folders of the individual types of the files like documents, excels, pdfs, videos etc. The extension will automatically will make the folder and the files will go in that folder according to their type automatically. At last, I can conclude you saying that File System organizer will be very helpful and will make our work easy. Keywords— local storage, organizing files
Undernutrition and obesity in pediatric patients admitted in a Romanian hospital
Authors:   Department of Gastroenterology, ”Grigore Alexandrescu” Emergency Children’s Hospital, Bucharest, Romania, Becheanu Cristina Adriana ,   ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Lesanu Gabriela ,   Department of Gastroenterology, ”Grigore Alexandrescu” Emergency Children’s Hospital, Bucharest, Romania,   ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Smadeanu Roxana Elena ,   Department of Gastroenterology, ”Grigore Alexandrescu” Emergency Children’s Hospital, Bucharest, Romania, Tincu Iulia Florentina ,   Emergency Department, ”Grigore Alexandrescu” Emergency Children’s Hospital, Bucharest, Romania
Published: July 2022

Aims. The determinants of children nutrition status varies around the globe in relation with socio-economic particularities, dietary habits and family lifestyle. The present study attempted to evaluate the changes and determinants of nutritional status of a representative children population from South Romania. Materials and methods. A prospective cross section study was performed in Grigore Alexandrescu Emergency Children’s Hospital from Bucharest between December 2010-February 2011. We enrolled 1529 children and anthropometric, dietary assessment and interview schedule were used for all the participants. Study design was similar with the one used in 2005, on similar condition (timing and participants). The population was divided in 2 age groups: 0-2 years and 2-18 years. Data analyze used SPSS software and the Data Analysis module of MICROSOFT EXCEL 2007. Chi-Squared Test was performed for hypothesis testing involving nominal variables (categorical), non-parametric Wilcoxon-Mann-Whitney Test for comparing values of two independent cohorts, Independent Sample T Test for comparing average values of two independent cohorts, and the ‘Correlate’ function /Pearson coefficient for proving associations between the parameters being considered. Results. The overall rate of undernutrition was 11% while 13% subjects were obese/overweight. Half of subjects with undernutrition came from low-income families. Compared to non-obese children, obese subjects regularly consume sweets and hyper caloric drinks (p<0.001), spend more time watching TV and less time doing physical activity (p<0.001). Comparing data 2005/2011 we revealed that there is a decreasing level of malnutrition for both age groups and there is a warring prevalence of overweight/obese children. Conclusions. Almost a quarter of subject had nutritional status modifications. Inappropriate dietary habits (hypercaloric, hyperglucidic) and sedentary lifestyle were the main determinants of overweight/ obesity. This study provides data for national database and it represents an important argue in order to establish children nutritional diseases prevention programs.
Extreme cerebral malformation – Clinical and ethical issues based on a case
Authors:   “Carol Davila” Medicine and Pharmacy University, Bucharest, Romania, Brezan Florin ,   Institute for Mother and Child Care “Prof. Dr. Alfred Rusescu”, Bucharest, Romania, Codreanu Ioana ,   “Carol Davila” Medicine and Pharmacy University, Bucharest, Romania, Cretu Rodica ,   Institute for Mother and Child Care “Prof. Dr. Alfred Rusescu”, Bucharest, Romania, Ghita Lucica ,   Institute for Mother and Child Care “Prof. Dr. Alfred Rusescu”, Bucharest, Romania, Ritivoiu Mirela ,   “Carol Davila” Medicine and Pharmacy University, Bucharest, Romania,   Institute for Mother and Child Care “Prof. Dr. Alfred Rusescu”, Bucharest, Romania, Goran Diana ,   “Carol Davila” Medicine and Pharmacy University, Bucharest, Romania, Anca Ioana Alina ,   “Carol Davila” Medicine and Pharmacy University, Bucharest, Romania,   Institute for Mother and Child Care “Prof. Dr. Alfred Rusescu”, Bucharest, Romania
Published: July 2022

Hydranencephaly represents one of the most rare cerebral malformations, with poor prognosis and negative impact on both family and society. Usually the patients remain in a permanent vegetative state and require unlimited medical care. Although the majority of affected babies die in utero or in the first days-months of life there have been cases in literature with prolonged survival, for 20 (1), 22 (2) and 32 (3) years. Therapeutically, the medical care provided are purely palliative and oriented to supporting vital function. Conclusions. Hydranencephaly is a rare brain malformation with poor prognosis, life expectancy and quality of life. Diagnosis imposes a number of ethical issues. The importance resides in the fact that prenatal detection represents an indication for therapeutic abortion. Another ethical issue raised is represented by medical care provided, which is exclusively palliative. Both surgical and novel therapeutic methods described by the literature, like endoscopic coagulation of choroid plexuses, do not influence the neurological status and the neuropsychomotor development (4). All this data should be clearly explained to parents and legal tutors for not raising any false hopes regarding the evolution.
Interrelaţia obezitate – depresie la copil şi adolescent
Authors:   Clinica 7 Acuţi, Spitalul Clinic de Psihiatrie Socola, Universitatea de Medicinǎ şi Farmacie „Gr. T. Popa“, Iaşi, România, Ciubară Anamaria , Burlea Lucian Ştefan ,   Universitatea de Medicinǎ şi Farmacie „Gr. T. Popa“, Iaşi, România, Anton-Pǎduraru Dana-Teodora ,   Clinica III Pediatrie, Universitatea de Medicinǎ şi Farmacie „Gr. T. Popa“, Iaşi, România, Burlea Marin ,   Clinica V Pediatrie, Universitatea de Medicinǎ şi Farmacie „Gr. T. Popa“, Iaşi, România, Untu Ilinca ,   Universitatea de Medicinǎ şi Farmacie „Gr. T. Popa“, Iaşi, România
Published: July 2022

Obezitatea şi depresia reprezintă două probleme fundamentale de sănătate publică la nivel mondial, obezitatea pediatrică fiind alarmantă atât per se, cât şi prin riscul menţinerii statutului de obez la vârsta adultă şi implicit a continuării expunerii la comorbidităţi. Pe de altă parte, depresia la copil este o veritabilă provocare diagnostică, dată fiind simptomatologia clinică mascată a acesteia, şi o necesitate date fiind consecinţele severe ale acesteia şi, în particular, modificările patologice asupra comportamentului alimentar. Lucrarea de faţă îşi propune realizarea unei sinteze a literaturii de specialitate actuale cu privire la resorturile comorbidităţii obezitate – depresie la copil vizând interrelaţia şi originea etiopatogenică comună.
Obesity – Depression interrelation in children and adolescent
Authors:   7th Clinic, Socola Clinical Psychiatry Hospital, „Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, Ciubara Anamaria , Burlea Lucian Stefan ,   „Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Anton-Paduraru Dana-Teodora ,   3rd Clinic of Pediatrics, „Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Burlea Marin ,   5th Clinic of Pediatrics, „Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Untu Ilinca ,   „Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

Obesity and depression represent two fundamental problems of public health at a global level; paediatric obesity is alarming both per se and through the risk of maintaining the obese status in adulthood and of continuing to be exposed to comorbidity, implicitly. On the other hand, depression in children is a genuine diagnostic problem (considering its masked clinical symptomatology) and a diagnostic necessity (considering its severe consequences and mostly the pathological alterations of food-related behaviour). This paper seeks to elaborate a synthesis of the current scientific literature regarding the causes of obesity – depression comorbidities in children, with a focus on the interrelation and common etiopathogenic origin.
Neonatal necrotizing enterocolitis: Clinical data and treatment possibilities
Authors:   Department of Paediatric Surgery, ”Sf. Maria“ Emergency Children Hospital, ”Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, Hanganu Elena , Stamatin Maria ,   Department of Neonatology, Regional Center of Neonatal Intensive Care Unit ”Cuza Voda”, ”Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, Aprodu Sandu Gabriel ,   Department of Paediatric Surgery, ”Sf. Maria“ Emergency Children Hospital, ”Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, Moscalu Mihaela ,   Department of Medical Informatics and Biostatistics, ”Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, Gavrilescu Simona ,   Department of Paediatric Surgery, ”Sf. Maria“ Emergency Children Hospital, ”Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

Objectives. The aim of this paper is to identify the correlations between the clinical evolution of the neonates with necrotizing enterocolitis (NEC) and the stage of disease, associated risk factors and the type of treatment used. Material and methods. A 6 years retrospective study was performed based on reviewing the casuistry of the Regional Centre of Neonatal Intensive Care Unit (NICU) „Cuza Voda” and 205 cases of necrotizing enterocolitis were identified from a total number of 6183 neonates admitted there. Patients were divided in to study groups based on the gestational age (GA) and birth weight (BW). The analysis protocol was realized based on a working sheet that included the epidemiological data of the patients, the risk factors, type of nutrition, age at diagnosis, stage of disease according to Bell classification, type of treatment (medical, surgical or combined), complications and the general evolution. The statistical data processing was performed in SPSS Statistics 20 program. Results. NEC had a frequency of 3.3% is the study group and was diagnosed in premature newborns in 75.6% of cases. The mean GA for the study group was 33 weeks. The mean BW was 1896 g with 43% of the cases in very low birth weight (VLBW) group and 31.2% in low birth weight (LBW) group. The percentage incidence of the risk factors was as follows: persistence of ductus arteriosus 19.5%, perinatal asphyxia 13.7% and respiratory distress 100% of cases. 75.5% were treated and discharged from NICU, 16.6% were transferred to Pediatric Surgery Department „Sf. Maria” and 3.9% died in NICU. From the 34 cases transferred19 cases were surgically treated: 8 cases with peritoneal drainage (PD), 8 cases with primary laparotomy (LAP) and 3 cases with PD and LAP. The survival rate in this group was 2.4% and for the medically treated group was 4.9%. Conclusions. Prematurity is statistically correlated with encountering advanced stages of enterocolitis at the time of diagnosis. The option for surgical treatment (peritoneal drainage or laparotomy) does not influence the results and early enteral feeding with formula is the most important risk factor for NEC followed by age of gestation and very low birth weight.
Sleep medicine in Romania – The results of a questionnaire applied to doctors of various medical specialties
Authors:   Medicover Pediatric Clinic, Bucharest, Romania, Oros Mihaela
Published: July 2022

Pediatric sleep medicine is an area of intense research. The importance of screening for obstructive sleep apnea syndrome (OSAS) has been emphasized in the recently published international guidelines for the diagnosis and management of childhood OSA. In Romania, the first steps of diagnosis and treatment of sleep disorders in children have been recently made and we wanted to assess the current awareness and management option in a group of HCPs. A self-administered questionnaire was sent by email to pediatricians, family doctors, medical doctors of other specialties, including pneumologists, psychiatrists and ENT specialists. The results, important for the qualitative information, show that pediatric sleep disorders, mainly OSAS, are diagnosed rather by specialists than by family doctors, and that in most cases the management strategy was re-evaluation of the child and/or referral to another specialist. Half of the respondents completed the final open question showing the need for improvement, both theoretical and practical knowledge, for a better communication between specialists and improvement of access to diagnostic tools, as well as increase of education of parents and older children and adolescents. Further research is needed to confirm these qualitative data, however the questionnaire allowed the identification of poor areas for various working groups, finally elaborating recommendations for various interventions which might influence the development of this field in our country as well.
Surrogate Inflammatory Markers and Some Correlates in Pre-dialysis Chronic Kidney Disease Patients: a cross-sectional study
Authors: Mamven Manmak , Ucha Ifeanyi , Adejumo Oluseyi
Published: July 2022

Objective: Chronic kidney disease is characterized by a state of chronic inflammation which is associated with poor cardiovascular disease outcomes. The study determined the prevalence of elevated neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as surrogate markers of inflammation and their association with some cardiovascular risk factors among pre-dialysis CKD patients.
Method: This was a cross-sectional study to determine and compare the prevalence of elevated NLR and PLR. The correlation between these surrogate inflammatory markers and some cardiovascular risk factors was determined. Data were analyzed using SPSS version 21 software. P-value of < 0.05 was taken as significant.
Results: This study involved 51 pre-dialysis CKD patients and 51 controls with mean ages of 50.96±11.42 years and 48.31±9.83 years, respectively. The prevalence of elevated NLR was significantly higher in the CKD group (35.3% vs13.7%; P=0.010). In the CKD group, there was significant negative correlation between NLR and eGFR (r= -0.393; P=0.004), hemoglobin concentration (r= -0.543; P=<0.001) and HDL (r= -0.292; P=0.037). There was significant positive correlation between NLR and PLR (r=0.669; P=<0.001), TC:HDL (r=0.334; P=0.017), AIP(r=0.289; P=0.042) and LDL:HDL (r=0.320; P=0.020). There was significant positive correlation between PLR, NLR (r=0.695; P=<0.001) and AIP (r=0.283; P=0.047). There was significant negative correlation between PLR and estimated GFR (r=- 0.448; P=0.001), hemoglobin concentration (r= -0.596; P=<0.001), serum albumin (r= -0.388; P=0.005), serum HDL-C (r= -0.387; P= 0.005).
Conclusion: NLR and PLR were significantly higher in pre-dialysis CKD patients and were associated with cardiovascular risk. They should be routinely used to identify those with high cardiovascular risk.
THE EFFECT OF WORK ENVIRONMENT AND WORKLOAD ON WORK COMMITMENT ON HEALTH ADMINISTRATORS AT SUNAN KUDUS RSI, CENTRAL JAVA
Authors: Ahmad Farid
Published: July 2022

Commitment is a condition in which workers sided with certain organizations and their goals and desires to maintain membership in their work. The middle of 2022. The research design uses a cross sectional approach. The population in this study were all health administrators at RSI Sunan Kudus, Central Java. The sample used in this study was 150 respondents. The endogenous variable is the workload, the exogenous variable is the work environment. This research uses Structural Equating Modeling (SEM) analysis with Smart PLS software application and Special Package for Statistical Science (SPSS). Data collection is done by distributing questionnaires. There is a direct effect of the work environment on the work commitment of health administrators by 20.9% with a T-statistic value of 3.115, there is a direct effect of workload on the work commitment of health administrators by 11.4% with a T-statistic value of 2.371. Thus, this study explains that the problems that occur can be studied in this study of 99.0% of data diversity while 0.1% is explained by other components. The management should make improvements to the work environment so that with frequent improvements this will help administrators increase their work commitment in the hospital.

Keywords: Burden, Work Commitment, Work Environment
The Interferometric Binary ϵ Cnc in Praesepe: Precise Masses and Age
Authors: Morales Leslie M. , Sandquist Eric L. , Schaefer Gail H. , Farrington Christopher D. , Klement Robert , Bedin Luigi R. , Libralato Mattia , Malavolta Luca , Nardiello Domenico , Orosz Jerome A. , Monnier John D. , Kraus Stefan , Le Bouquin Jean-Baptiste , Anugu Narsireddy , ten Brummelaar Theo , Davies Claire L. , Ennis Jacob , Gardner Tyler , Lanthermann Cyprien
Published: July 2022

We observe the brightest member of the Praesepe cluster, ϵ Cnc, to precisely measure the characteristics of the stars in this binary system, en route to a new measurement of the cluster’s age. We present spectroscopic radial velocity measurements and interferometric observations of the sky-projected orbit to derive the masses, which we find to be M
1/M
⊙ = 2.420 ± 0.008 and M
2/M
⊙ = 2.226 ± 0.004. We place limits on the color–magnitude positions of the stars by using spectroscopic and interferometric luminosity ratios while trying to reproduce the spectral energy distribution of ϵ Cnc. We reexamine the cluster membership of stars at the bright end of the color–magnitude diagram using Gaia data and literature radial velocity information. The binary star data are consistent with an age of 637 ± 19 Myr, as determined from MIST model isochrones. The masses and luminosities of the stars appear to select models with the most commonly used amount of convective core overshooting.
Shocks in Radiatively Driven Time-dependent, Relativistic Jets around Black Holes
Authors: Joshi Raj Kishor , Debnath Sanjit , Chattopadhyay Indranil
Published: July 2022

We study time-dependent relativistic jets under the influence of the radiation field of the accretion disk. The accretion disk consists of an inner compact corona and an outer sub-Keplerian disk. The thermodynamics of the fluid is governed by a relativistic equation of state (EOS) for multispecies fluid that enables us to study the effect of composition on jet dynamics. Jets originate from the vicinity of the central black hole, where the effect of gravity is significant and traverses large distances where only special relativistic treatment is sufficient. So we have modified the flat metric to include the effect of gravity. In this modified relativistic framework we have developed a new total variation diminishing routine along with a multispecies EOS for the purpose. We show that the acceleration of jets crucially depends on flow composition. All the results presented are transonic in nature; starting from very low injection velocities, the jets can achieve high Lorentz factors. For sub-Eddington luminosities, lepton-dominated jets can be accelerated to Lorentz factors >50. The change in radiation field due to variation in the accretion disk dynamics will be propagated to the jet in a finite amount of time. Hence, any change in radiation field due to a change in disk configuration will affect the lower part of the jet before it affects the outer part. This can drive shock transition in the jet flow. Depending on the disk oscillation frequency, amplitude, and jet parameters, these shocks can collide with each other and may trigger shock cascades.
Electrostatic Solitary Waves and Electron-beam Instabilities in the Separatrix Region of Magnetic Reconnection
Authors: Chang Cong , Huang Kai , Lu Quanming , Lu San , Yu Xiancai , Wang Rongsheng , Sang Longlong , Gao Xinliang
Published: July 2022

Using 2D particle-in-cell (PIC) simulations, the generation of electrostatic solitary waves (ESWs) and the associated plasma waves in symmetric magnetic reconnection are studied, and multiple kinds of ESWs with different propagating speeds are identified. Near the current sheet in the outflow region, there are two kinds of ESWs propagating away from the X line: their propagating speeds are about 0.73V
Te0 and 1.2V
Te0 (where V
Te0 is the initial electron thermal velocity), and their generation is associated with the Buneman instability and the electron two-stream instability, respectively. In the separatrix region, there is one kind of ESW propagating toward the X line with a propagating speed of about 1.2 V
Te0, which is formed during the nonlinear evolution of the electron two-stream instability. We also run a case with a guide field, and there exist two kinds of ESWs: the ESWs propagating away from the X line can be generated near the separatrices with electron outflow, while the ESWs propagating toward the X line can be generated near the separatrices with electron inflow. The two kinds of ESWs are associated with the electron two-stream instability and the Buneman instability, respectively.
NASA’s Double Asteroid Redirection Test (DART): Mutual Orbital Period Change Due to Reshaping in the Near-Earth Binary Asteroid System (65803) Didymos
Authors: Nakano Ryota , Hirabayashi Masatoshi , Agrusa Harrison F. , Ferrari Fabio , Meyer Alex J. , Michel Patrick , Raducan Sabina D. , Sánchez Paul , Zhang Yun
Published: July 2022

The Double Asteroid Redirection Test (DART) is the first planetary defense mission to demonstrate the kinetic deflection technique. The DART spacecraft will collide with the asteroid Dimorphos, the smaller component of the binary asteroid system (65803) Didymos. The DART impact will excavate surface/subsurface materials of Dimorphos, leading to the formation of a crater and/or some magnitude of reshaping (i.e., shape change without significant mass loss). The ejecta may eventually hit Didymos’s surface. If the kinetic energy delivered to the surface is high enough, reshaping may also occur in Didymos, given its near-critical spin rate. Reshaping on either body will modify the mutual gravitational field, leading to a reshaping-induced orbital period change, in addition to the impact-induced orbital period change. If left unaccounted for, this could lead to an erroneous interpretation of the effect of the kinetic deflection technique. Here we report the results of full two-body problem simulations that explore how reshaping influences the mutual dynamics. In general, we find that the orbital period becomes shorter linearly with increasing reshaping magnitude. If Didymos’s shortest axis shrinks by ∼0.7 m, or Dimorphos’s intermediate axis shrinks by ∼2 m, the orbital period change would be comparable to the Earth-based observation accuracy, ∼7.3 s. Constraining the reshaping magnitude will decouple the reshaping- and impact-induced orbital period changes; Didymos’s reshaping may be constrained by observing its spin period change, while Dimorphos’s reshaping will likely be difficult to constrain but will be investigated by the ESA's Hera mission that will visit Didymos in late 2026.
Comparison of Albendazole and Mebendazole on Soil-Transmitted Helminth Infections among School-Aged Children
Authors: Husin Nirmalia , Pasaribu Ayodhia Pitaloka , Ali Muhammad , Suteno Erwin , Suteno Erwin , Wijaya Wilhans , Pasaribu Syahril
Published: July 2022

BACKGROUND: Anthelmintics, such as albendazole and mebendazole, are widely used to treat soil-transmitted helminths (STHs). With its extensive usage and administration along with other medical prescriptions, different environmental conditions, etc., some studies have reported unsatisfactory efficacy from albendazole to treat STHs.

AIM: To observe the efficacy of albendazole and mebendazole as a single dose in treating STH infections in elementary school children.

METHODS: An open randomized clinical trial was conducted in Batubara, North Sumatra, comparing the efficacy of albendazole and mebendazole. Samples were 6−12-year-old children infected with STHs based on Kato-Katz examination. A Chi-square test was performed to compare the cure rate and a t-test was done to compare the number of eggs per gram (EPG) feces in both groups.

RESULT: A total of 199 children from 426 met the study criteria. There was a significant difference (p < 0.05) in the cure rate of Ascaris lumbricoides infections at 87.5% and 31% for albendazole and mebendazole groups, respectively. The cure rate of Trichuris trichiura infection at 61.5% and 65.6% with albendazole and mebendazole, respectively, and there was no significant difference (p > 0.05). There was a significant reduction in the number of eggs of all STHs after the treatment either with albendazole or mebendazole.

CONCLUSION: Single-dose albendazole has better efficacy against Ascaris lumbricoides infection than mebendazole. Meanwhile, both albendazole and mebendazole have high efficacy in reducing the number of eggs.
Prospective Descriptive Study of Radiological and Functional Outcomes of Volar Barton’s Fracture Fixed by Volar Locked Plate
Authors: Al-Faily Haider O. Hayat Ali , Nasir Hussein Ali , Mohammed Thaer Rasim , Al-Edanni Mohammed
Published: July 2022

BACKGROUND: Volar Barton’s fracture is a shearing mechanism of injury that results in fracture and subluxation of distal end radius in which volar rim of the distal radius is displaced with hand and carpus. Open reduction and volar plate fixation ensure more stable change of displacement, preservation of reduction, and early mobilization.

AIM: This study aims to assess the functional and radiological outcome results of volar Barton’s fracture treated by volar buttress plate using the demerit points system of Gartland and Werley.

PATIENTS AND METHODS: This study is a prospective descriptive observational study on 32 patients who were treated with ORIF by volar buttress plate for isolated volar Barton’s fractures between February 2018 and June 2020 in Alkindy teaching hospital/Baghdad/Iraq. All volar Barton’s fracture cases satisfying the inclusion criteria which included patient over 18 years, isolated fracture, medically fit, and <5 days old injuries, while fractures extend to radius shaft, compound fractures, and associated with other injuries were excluded from the study. All fractures are fixed by volar locked plate followed up for 12 week’s duration for functional and radiological assessment using the Demerit points system of Gartland and Werley.

RESULTS: Most cases were in the age group below 40 years, average age 38 years (range 19–64 years), male patient was 69%, side of involvement was right wrist in 75% of cases, falling on an outstretched hand account 50%, while roads traffic accidents in 37.5%, fall from a height in 6.25%, and direct trauma in 6.25%. The final sequel of the results was average volar tilt was 11.1°, the radial shortening average was 4 mm, the radial inclination average was 19.9°, and the ulnar variance was 0.3 mm. Functional outcomes depending on Gartland and Werley’s score were 50% as excellent results, 43.75% as good results, 6.25% as fair results, and no poor results in this study.

CONCLUSIONS: Volar locking buttress plate provides fracture stability and early mobilization, therefore, recovery of daily live activity in a short time.
The Effect of Gambier Catechin Isolate on Cervical Cancer Cell Death (HeLa Cell Lines)
Authors: Rahmaddiansyah Refa , Hasani Suci , Zikrah Azizah Amatu , Arisanty Dessy
Published: July 2022

BACKGROUND: Cervical cancer is the second most common type of cancer in women worldwide. Human Papilloma Virus infection on the surface of the cervix is the most common cause which can cause abnormal growth of cervical cells.
AIM: This research was conducted in vitro which aims to determine whether catechin compounds can inhibit the growth and regulation of cervical cancer cells (HeLa cell line).
METHODS: This is experimental research using the colourimetric assay method and qualitative observation of cervical cancer cell morphology (HeLa cell line) under a fluorescence microscope. The administration of catechin compounds was tested at different concentrations to HeLa cells, namely 1000 g/ml, 500 g/ml, 250 g/ml, 125 g/ml, 62.5 g/ml, 31.25 g/ml.
RESULTS: The smallest cell viability was obtained from a concentration of 1000 g/ml which was 5.98% while the largest cell viability was found at a concentration of 31.25 g/ml, which was 40.01%. The resulting IC50 value was 22.91 g/ml. Gambier catechin compounds have very high antioxidants because they contain an IC50 value < 50 g/ml. The effect of gambier catechin compounds on HeLa cell death can be found by increasing the percentage of dead cells. The difference in the fluorescence images of HeLa cells in the experimental group was assessed based on the percentage of the number of cells that died or underwent apoptosis, which was marked by a red or orange fluorescent image. At the concentration of IC25, 31.87% of dead cells were found, the concentration of IC50 was 51.09% of dead cells, and the concentration of IC75 was 82.51% of dead cells. The test results showed that there was a significant difference in the average percentage of cells undergoing apoptosis in all study groups with p <0.05.
CONCLUSION: Based on research, it can be concluded that catechin compounds could inhibit the growth and regulation of cervical cancer cells (HeLa cell line). Later, it has the potential to be developed as an anticancer candidate for cervical cancer.
Keyword: Cervical cancer, Catechin, Apoptosis, HeLa cell line, Cell death.
Correlation between Interleukin-6 and Ferritin Serum in Pediatric Sepsis Patients
Authors: Wijayanti Ida Ayu Agung , Gustawan I Wayan , Karyana I Putu Gede , Sidiartha I Gusti Lanang , Gunawijaya Eka , Mahalini Dewi Sutriani , Widnyana AANKP
Published: July 2022

BACKGROUND: Sepsis is the leading cause of death in children. Sepsis is caused by dysregulation of  immune system that triggers the production of pro-inflammatory cytokines, one of which is interleukin-6 (IL-6). In addition several markers of infection also increase such as c-reactive protein (CRP) and procalcitonin (PCT), moreover in sepsis serum ferritin also increase. Serum ferritin is secreted by stimulation of pro-inflammatory cytokines such as TNF-α, interleukin-1 (IL-1) and IL-6 that occur in the inflammatory process.
AIM: to prove correlation between Interleukin-6 and ferritin serum in pediatric sepsis patient.
METHOD: This was cross-sectional study. Subjects were children aged 1 month-18 years with sepsis in pediatric intensive care unit (PICU) and intermediate ward (IW) at Sanglah General Hospital Denpasar in period of September 2020 – June 2021. Statistical analysis was done by Pearson correlation test.
RESULTS: Total 37 subjects were analyzed in this study. The median level of Interleukin-6 was 12 pg/ml (range, 1-355 pg/ml) and the median of ferritin level was 997 (range, 180-13418 ng/mL). The correlation between interleukin-6 and serum ferritin showed moderate positive correlation (r=0.54) which was statistically significant (p=0.001). After adjusting for the confounding variables, namely age, gender, nutritional status and time of sampling using partial correlation, the correlation between IL-6 and ferritin became strong with r=0.702 and p=0.00.
CONCLUSION: There was a significant positive correlation after adjusting for the confounding variables between Interleukin-6 level and ferritin in pediatric sepsis patient.
In vitro Investigation of Antibiotic Combinations against Multi- and Extensively Drug-Resistant Klebsiella pneumoniae
Authors: Dobreva Elina , Ivanov Ivan , Donchev Deyan , Ivanova Krasimira , Hristova Rumyana , Dobrinov Veselin , Dobrinov Veselin , Sabtcheva Stefana , Kantardjiev Todor
Published: July 2022

Objectives: Community and hospital acquired K. pneumoniae infections have become a ubiquitous medical issue due to the limited treatment options and high mortality rate therefore the aims of this study are in vitro investigation of double antimicrobial combinations against multidrug resistant (MDR) and extensively drug resistant (XDR) isolates.
Materials and Methods: Antimicrobial susceptibility of twelve isolates from eight Bulgarian hospitals was determined to study the interaction effect of selected double combinations in accordance to fractional inhibitory concentration (FIC) method. Furthermore, the isolates were subjected to genotyping by Multilocus sequence typing (MLST) and detection of carbapenemase genes by multiplex PCR. The results were assessed by groups of strains with either NDM or KPC carbapenemase.
Results: Nine antimicrobial combinations: meropenem-colistin, meropenem-fosfomycin, meropenem-gentamicin, meropenem-rifampicin, meropenem-tigecycline, colistin-fosfomycin, colistin-gentamicin, colistin-rifampicin and colistin-tigecycline were tested for synergism on twelve K. pneumoniae, producing either KPC-2 (KPC-KP, 41.7%, 5/12) or NDM-1 (NDM-KP, 58.3%, 7/12). The isolates were distributed in three sequence types: ST11 (58.3%, 7/12), ST15 (25%, 3/12) and ST258 (16.7%, 2/12). All KPC-KP (ST258 and ST15) originated from three hospitals. The rest were NDM-1 carriers isolated from six hospitals and belonged to ST11. The highest synergistic effect was determined for MER-GEN (83.3%, 10/12) and COL-RIF (83.3%, 10/12). The MER-FOS combination was most efficient against NDM-KP, opposite to the KPC strains. Antagonism was not observed for any combinations.
Conclusions: The evaluated joint synergistic effect of the MER-GEN and COL-RIF may facilitate the treatment options for patients infected with NDM- and KPC-KP, whereas MER-FOS is highly synergetic against NDM-KP.
The Association between Modifiable Risk Factor with Inflammatory Marker in Knee Osteoarthritis Women
Authors: Arnadi Arnadi , Afriwardi Afriwardi , Ali Hirowati , Sahputra Roni Eka
Published: July 2022

Background: IL-1β and TNF-α are vital inflammatory cytokines in the pathophysiological process of Osteoarthritis (OA). Several risk factors can increase the expression of these cytokines, such as BMI, physical activity, and menopausal status.
 
Aims: This study aims to determine the relationship of modifiable factors with synovial fluid IL-1β and TNF-α levels in knee OA women.
 
Methods: The cross-sectional study was conducted at the orthopedic poly hospital Arifin Achmad Riau Province and Ibnu Sina Hospital in Pekanbaru City. A total of 93 women with knee OA were taken as samples by consecutive sampling. Data were obtained directly from respondents by conducting interviews using a questionnaire, measuring weight and height, examining levels of IL-1β and TNF-α from the synovial fluid using the enzyme-linked immunosorbent assay (ELISA) method. The data were processed computerized using the Person correlation test, One Way Anova, and t-Test. The statistical analysis results were considered significant if the p-value was 0<05.
 
Results: the average age of subjects was 60.67 + 9.99 years, 87.8% aged > 40 years, 84.9% had menopause, and at most had moderate physical activity degrees (51.6%). The mean BMI was 27.18+4.17, the average of IL-1β 424.73+188.01 pg/mL, and TNF-α 105,17+48.98 ng/L. There was a significant positive correlation with moderate strength between BMI and levels of IL-1β and TNF-α synovial fluid (p=0.037, r=0.217, and p=0.047, r=0.207).
 
Conclusion: BMI is a risk factor for IL-1β and TNF-α levels in synovial fluid of knee joints in women with OA, but physical activity and menopausal status are not risk factors.
Potential of Moringa Leaf Cookies to Increast Breastmilk Production in Postpartum Mothers
Authors: Pujiastuti Rr. Sri Endang , Salsabila Dinar Indri Bakti , Anwar M. Choiroel
Published: July 2022

BACKGROUND: Exclusive breastfeeding can be beneficial for both the baby and the mother. Efforts are needed to increase milk production so that mothers can still only breastfeed their babies. Moringa leaves can increase breast milk production because they contain flavonoids and polyphenols. Moringa leaf cookies were chosen because they are liked by many nursing mothers, can be stored for a relatively long time, and processing can lose nutrients.

AIM: The purpose of the study was to analyze the effectiveness of Moringa leaf cookies in increasing breast milk production.

METHODS: This was a quasi-experiment with pre-test and post-test non-equivalent control group design. The number of samples was 46 respondents on the 1st day of primiparous postpartum mothers who were divided into two into 23 intervention groups given Moringa leaf cookies (125 g/day) for 14 days and Vitamin A and Fe tablets and 23 control groups were given Vitamin A and Fe tablets. In this study, milk production was measured through indicators of infant weight with the right level of accuracy. The analysis used in this study is the paired t-test, independent t-test, and multivariate Test.

RESULTS: There was a difference before and before being given Moringa leaf cookies in the intervention group, while the statistical test results obtained p = 0.000 < 0.05. There was a difference in body weight in the intervention group and the control group and the results of the statistical test p = 0.000 < 0.05.

CONCLUSION: Moringa leaf cookies (125 g/day) for 14 days were effective in increasing breast milk production based on the baby’s weight.