bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical assessment of three-dimensional printing assisted osteotomy guide plates in precise osteotomy of adult talipes equinovarus
Authors: Zhang Yuan-Wei , Xiong Liang-Yu , Huang Zu-Tai , Gao Wen-Cheng , Xiao Xin , Zhang Su-Li , Ni Wen-Yan , Deng Liang
Published: February 2020

Objectives: This current research is aimed to assess clinical efficacy and prognosis of three-dimensional (3D) printing assisted osteotomy guide plate in precise osteotomy of adult talipes equinovarus (ATE). Materials and Methods: We included a total of 27 patients of ATE malformation (including 12 males and 15 females) from January 2014 to June 2018 in current research. The patients were divided into the routine group (n=12) and 3D printing group (n=15) based on different operative methods. The parameters, including the operative time, intraoperative blood loss, complications, time to obtain bony fusion, functional outcomes based on American Orthopedic Foot and Ankle Society (AOFAS) and International Congenital Clubfoot Study group (ICFSG) scoring systems between the two groups were observed and recorded regularly. Results: The 3D printing group exhibits superiorities in shorter operative time, less intraoperative blood loss, higher rate of excellent and good outcomes presented by ICFSG score at last follow-up (P< 0.001, P< 0.001, P =0.019) than the routine group. However, there was no significant difference exhibited in AOFAS score at last follow-up and total rate of complications between the two groups (P=0.136, P =0.291). Conclusions: Operation assisted by 3D printing osteotomy guide plates for correcting the ATE malformation is novel and feasible, which might be an effective method to polish up the precise osteotomy of ATE malformation and enhance the clinical efficacy.
A New DDoS Detection Method in Software Defined Network
Authors: dehkordi afsaneh banitalebi , Soltanaghaei MohammadReza , boroujeni farsad zamani
Published: February 2020

Software Defined Networking (SDN) is a new network architecture in which network control is separated from direct traffic and is programmed directly. Any change in network information and its configuration can be easily implemented in software by using the controller. Although SDN networks with their new structure and controller make way for new and innovative applications for network administrators, but the security challenges and attacks of SDN networks have created problems for these networks. One of these malicious attacks is Distributed Denial of Service (DDoS) attacks. The DDoS attack is aimed at removing machine and network resources from its legitimate users. In this paper, we propose a hybrid method for detecting DDoS attacks in SDN Networks. This method is consisting of statistical and machine learning method. Statistical method calculates the new correlation measure among all features and the dynamic thresholds, then extracts a portion of the data is recognized as attack. This portion is then redirected to the machine learning section to increase the DDoS detection accuracy. The experimental results on UNB-ISCX, CTU-13 and ISOT datasets showed that the proposed method outperforms the existing techniques in terms of the accuracy of detecting DDOS attacks in SDN networks.
Selection of foraging and commuting habitats of the greater horseshoe bat, revealed by high-resolution GPS-tracking
Authors: Fujioka Emyo , Yoshimura Koki , Ujino Tomohiro , Yoda Ken , Fukui Dai , Hiryu Shizuko
Published: February 2020

Background Echolocating bats make a series of decisions to select their flight routes based on auditory information obtained by sonar; accumulations of these flight routes are represented as daily movement patterns. However, there is still a lack of a unified understanding of continuous movements of echolocating bats in the wild from small to large spatial scales (i.e., from meters to tens of kilometers). Methods In this study, we investigated nightly flight paths of the Japanese greater horseshoe bat, Rhinolophus ferrumequinum nippon , using high-resolution GPS data loggers. Our aim was to identify foraging and commuting behavior based on the observed movement patterns and to investigate the relationship between these movement types and specific habitats. Results We found that the majority of tagged bats alternated between foraging and commuting behavior throughout the tracking period, and one individual moved 23.6 km from its roost. The distance between two successive foraging sites was on average 332 ± 398 m (mean ± standard deviation), and half of all foraging periods lasted less than 3 min. An analysis of habitat preferences revealed that the bats preferred conifer plantation and natural forests as pathways and feeding habitats. Particularly, they locally traveled along forest roads at flight speeds significantly higher than those flown over other habitats. Conclusions Our findings suggest the forests and their structures have a great influence on the nocturnal behavior of the greater horseshoe bats. Although this study has a descriptive character due to a relatively small number of tagged individuals, it was possible to elucidate the small-scale interactions between wild Rhinolophus bats and their environment using the latest high-resolution GPS technology, which will allow us to give new insights into the foraging ecology of echolocating bats in the wild.
Reseña: Enever, Janet, and Lindgren, Eva (2017). Early language learning in school contexts: Complexity and mixed methods. Bristol, United Kingdom: Multilingual Matters.
Authors: Huerta Bon Andrea
Published: February 2020

El volumen Early Language Learning in School Contexts: Complexity and Mixed Methods de Janet Enever y Eva Lindgren explora la implementación de los métodos mixtos de investigación para el estudio del aprendizaje temprano en contextos de escolarización. Este volumen incluye estudios recientes y multidisciplinarios que adoptan métodos mixtos para su investigación. Aunque existen otros estudios/colecciones que analizan, por ejemplo, el crecimiento de los métodos mixtos de investigación (Zha & Tu, 2015), este es el primer volumen que incorpora en su totalidad los métodos mixtos para estudios en el ámbito del aprendizaje de las lenguas en tempranas edades.
Innovative Approaches to Positioning in Marketing
Authors: Sheriakov Oleg Olegovich
Published: February 2020

The article deals with the modern features of positioning and repositioning in marketing, as well as innovative approaches to positioning, analyzed on specific examples of companies that have initiated their use.
O PRZEMIANACH PRAWA KRAJOWEGO PO ROZBIORACH RZECZYPOSPOLITEJ W ŚWIETLE WYKŁADU ‘PRAWO POLSKO-LITEWSKIE’ [IGNACEGO DANIŁOWICZA]
Authors: Godek Sławomir
Published: February 2020

W zbiorach lwowskich zachował się bardzo obszerny rękopis zawierający tekst wykładu na temat prawa polsko-litewskiego. Prawdopodobnie powstał on w końcu lat dwudziestych XIX w. i był dziełem Ignacego Daniłowicza. Tekst wykładu dostarcza okazji do poczynienia licznych obserwacji o zmianach jakich pod wpływem aktów rosyjskich doznało prawo polsko-litewskie w początkach XIX w. Zmiany te objęły w różnym stopniu wszystkie dziedziny prawa.
UWAGI HISTORYCZNO-PRAWNE NA TEMAT MAKSYMY ‘DE MINIMIS NON CURAT LEX’ W PRAWIE ANGIELSKIM (XIII-XIX WIEK)
Authors: Korporowicz Łukasz Jan
Published: February 2020

Zasada de minimis non curat lex jest powszechnie stosowana zarówno w prawie angielskim, jak i przez prawników reprezentujących inne porządki prawne zaliczane do rodziny common law Współcześnie okoliczności stosowania zasady budzą wątpliwości. Mimo jej racjonalnego uzasadnienia, trudno jest obecnie jednoznacznie wskazać kiedy należy ją stosować. W artykule przedstawiona została geneza zasady oraz jej interpretacja zarówno w literaturze, orzecznictwie jak i w dyskursie parlamentarnym po wiek XIX.
MODEL EDUKACJI RELIGIJNEJ W REPUBLICE ESTONII
Authors: Ciechanowska Justyna , Szwed Katarzyna
Published: February 2020

Estonia jest przykładem państwa, które wprowadziło model niewyznaniowej fakultatywnej formy nauczania religii w szkołach. Uregulowanie tej kwestii ma istotne znaczenie z punktu widzenia relacji państwo – Kościół. Konstytucja Estonii sankcjonuje brak istnienia Kościoła państwowego, a także gwarantuje równy status prawny Kościołom i związkom wyznaniowym. Nauczaniu religii w szkole nie poświęcono uwagi w ustawie zasadniczej. Również w aktach niższego rzędu kwestia ta została potraktowana lakonicznie. W 2010 r. wprowadzono jednak istotną nowelizację obowiązującego prawodawstwa. Ujednolicono program nauczania dla przedmiotu, który odtąd stanowi wytyczne obowiązujące dla wszystkich szkół. Estonia jest uznawana za kraj silnie zlaicyzowany. Wpływ na to miały doświadczenia historyczne, które warunkują stosunek Estończyków wychowania religijnego. Jego rola jest marginalizowana w systemie nauczania, a równocześnie wzbudza liczne kontrowersje.
‘Usus’ jako sposób wejścia kobiety pod władzę jej męża
Authors: Chmielecka Magdalena
Published: February 2020

W artykule poruszone zostały kwestie związane z instytucją usus stanowiącą jeden ze sposobów wejścia żony pod władzę męża. Artykuł porusza zagadnienia związane z genezą tejże instytucji. Autor zastanawia się także nad znaczeniem umiejscowienia instytucji usus w źródłach. Podstawowym zagadnieniem badawczym jest wyznaczenie terminu rozpoczęcia biegu usus, zatem pewnego rodzaju „zaużywania czy też zasiedzenia”, a w konsekwencji również zakończenie tego terminu. Ponadto autor porusza kwestie związane z usurpatio trinoctii.
GLOSA DO POSTANOWIENIA SĄDU NAJWYŻSZEGO Z 20 STYCZNIA 2017 R., IV KK 451/16, «LEX» NR 2241400
Authors: Budyn-Kulik Magdalena
Published: February 2020

Sąd Najwyższy w postanowieniu z 20 stycznia 2017 r., IV KK 451/16, «Lex» nr 2241400, stwierdził, że przyjęcie kumulatywnej kwalifikacji prawnej czynu z reguły wpływa na wyższy stopień jego społecznej szkodliwości, przekładając się na wyższy stopień winy i możliwość wymierzenia surowszej sankcji karnej. Glosa jest krytyczna. Czyn popełniony przez sprawcę stanowi fakt. Szkoda wyrządzona społeczeństwu pozostaje taka sama, niezależnie od sposobu opisania jej za pomocą przepisów prawnych. Tylko jeżeli z kumulatywnej kwalifikacji zostanie usunięty przepis obwarowany karą surowszą, wymierzona kara może być łagodniejsza.
SEMINARIUM NAUKOWE „SUBSTYTUCJA – ZAMIENNICTWO – SWITCH LEKÓW BIOLOGICZNYCH”, WARSZAWA 18 CZERWCA 2018 R.
Authors: Oręziak Bartłomiej
Published: February 2020

.
FUNKCJE POSTĘPOWANIA SPRAWDZAJĄCEGO W PROCESIE KARNYM
Authors: Abramek Monika
Published: February 2020

Artykuł dotyczy postępowania sprawdzającego uregulowanego w art. 307 k.p.k. Autorka dokonuje analizy tej instytucji procesowej z perspektywy jej funkcji w polskim procesie karnym. W początkowej części pracy wskazuje na najważniejsze założenia związane z ww. regulacją, a następnie, w nawiązaniu do celu czynności sprawdzających, podejmuje próbę odczytania zamiarów ustawodawcy związanych z funkcjami tej instytucji. Następnie rozważania dotyczą poszczególnych funkcji postępowania sprawdzającego. Autorka wskazuje na uzasadnienie ich wyodrębnienia i związane z tym aspekty karnoprocesowe.
WYSTĘPEK FINANSOWANIA TERRORYZMU (ART. 165A K.K.) W KONTEKŚCIE PROBLEMÓW ZWIĄZANYCH ZE STRONĄ PODMIOTOWĄ TEGO PRZESTĘPSTWA
Authors: Golonka Anna
Published: February 2020

Przedmiotem opracowania są zagadnienia związane z przestępstwem finansowania terroryzmu określonym w art. 165a k.k. Przepis ten w ciągu ostatnich dwóch lat był już dwukrotnie nowelizowany. Druga z nich, przeprowadzona ustawą z dnia 23marca 2017 r., przewidziała daleko idącą modyfikację typów czynów zabronionych uregulowanych w art. 165a k.k., w tym ustanawiając karalność nieumyślnego finansowania terroryzmu. Nowe brzmienie, jakie przybrał ten przepis zostało podyktowane zmianami w regulacjach wspólnotowych, a także wskazaniami Komitetu Moneyval, które legły u podstaw uzasadnienia niekoniecznie zasadnej nowelizacji. Co więcej, za jej sprawą w przepisie tym znalazł się niejeden zapis, który budzi poważne zastrzeżenia, zwłaszcza z perspektywy ratio legis zmian, tudzież zgodności z zasada określoności. Niedoskonały kształt tego przepisu budzi jednocześnie wątpliwości związane z możliwością jego praktycznego stosowania, a w konsekwencji również samą efektywnością zwalczania finansowania terroryzmu. Odnosi się to przede wszystkim do aspektów dotyczących strony podmiotowej typów czynów zabronionych opisanych w art. 165a k.k. Problematyka ta znajduje rozwinięcie w przedmiotowym artykule naukowym.
Construction of information design theory
Authors: Nishino Nariaki
Published: February 2020

Designing, testing and manufacturing new technologies is a complex process that often requires many redesigns and rethinks. There are multiple criteria a new technological product must meet. Examples include the fact that it must provide a useful function, it must execute that function
efficiently and effectively and it must be user friendly. In addition, cost of production and of sale are key considerations. Generally, once the manufacturer is satisfied with the results in all the criteria, the product can be released and sold. This iterative process whereby designs for
manufacturing are gradually improved is the standard engineering approach. It is an extremely reliable way to ensure your product satisfies the basic criteria you set for it at the beginning. However, this is where the intellectual effort behind the design process stops. A product is made
and, potentially, sells well and follow ups designed, but often little thought is put into unintended side effects of it. Dr Nariaki Nishino, who is an Associate Professor at the Department of Technology Management for Innovation, School of Engineering in The University of Tokyo, explains
that new technology often receives little scrutiny of its unplanned effects. 'This is particularly true of modern technologies involving the digitisation of previously analogue products,' he outlines. Over the last 10 years, it has been generally seen as a positive and desirable to digitise
as much as possible. Particularly, it has been seen as important to integrate digitised products extensively so that data from one is shared with another, etc. 'Such data sharing and integrated technology can provide many benefits for the user, however, there are side effects and important
consequences to the sharing of so much personal data,' confirms Nishino. 'These unintended consequences are known as artefacts of the product and after ignored in the design process.' More broadly, such artefacts of engineering can include a wide range of the negatives of modern life –
environmental problems, loneliness, urban decay. Nishino is a key team member of the Research into Artefacts, Centre for Engineering (RACE) division at The University of Tokyo, which was set up to examine how engineering could start considering these artefacts in the design process.
Development of tough hybrid materials by regulated crystallization of hydroxyapatite inspired by bone formation
Authors: Mizutani Tadashi
Published: February 2020

Materials science has gifted us incredible substances with which the modern world is built. From construction materials, like cement and steel, to electronics, like solar panels and touch screens, advances in our understanding of synthesis and molecular structures allows these materials
to become cheaper, better and widely applicable. Unfortunately, there are still limits to what is achievable with the current incarnations of mechanical, electronic and biological material. These limits can be structural whereby the material doesn't have the physical properties to fulfil the
demands. In other cases, the cost of designing or fabricating the material for the job is too great. Other times the fabrication process leads to significant environmental damage or the product itself ends up contributing to pollution and environmental harm. For example, marine microplastic
pollution caused by our widespread reliance on plastics. Overcoming these challenges is the next frontier of materials science and for many researchers the solution is one that humans have relied on for ages, literally turning back to nature for inspiration. Bio-functional chemistry expert
Professor Tadashi Mizutani, based in the Department of Molecular Chemistry and Biochemistry at Doshisha University in Kyoto, Japan, explains that bioinspired products are not a new concept. 'These are synthetic materials whose function, properties or structure mimic those of naturally occurring
materials,' Mizutani says. Solar panels are a great example of a bioinspired material as they are designed to mimic photosynthesis. 'In many cases the natural product vastly outperforms any synthetic or man-made product.' Furthermore, not only can these natural materials outperform synthetic
ones, because they are derived from natural sources, they are not harmful to the environment and are readily degradable. 'Contamination of sea water by microplastics is a serious problem, however, a biomimetic approach to mechanical materials can solve this issue if the developed composite
can be degraded in the environment,' he outlines. For these reasons, Mizutani and his colleagues are working to understand the mechanism behind the formation of bioceramics, such as bones, teeth and seashells.
Study on high power and control of metamaterial THz QCLs
Authors: Lin Tsung-Tse
Published: February 2020

Quantum-cascade lasers (QCLs) are a special kind of semiconductor laser. They emit in the mid- and long-wave infrared bands and, instead of operating on laser transitions between different electronic bands, they operate on intersubband transitions of a semiconductor structure. Their
potential has piqued the interest of researchers, with possible applications in a number of areas, including precision sensing, military applications and spectroscopy. As they have a wide tuning range and fast response time, their use allows for precision in devices, such as element detectors
and gas analysers. A team of researchers based at the THz Quantum Device Laboratory Center for Advanced Photonics RIKEN in Japan is working on designing and fabricating high output power operation and high temperature operation terahertz (THz) QCLs with a variety of potential uses.
Directed Self-Assembly based Interconnect Technology for Next-Generation 2D/3D LSI
Authors: Fukushima Takafumi
Published: February 2020

Three-dimensional integrated circuits (3D ICs) contain multiple layers of active device chiplets and have the potential to improve signal transfer and the overall performance of a microelectronic systems, while saving energy. Dr Takafumi Fukushima is an Associate Professor based in
the Department of Mechanical Systems Engineering, Tohoku University, Japan, whose research revolves around 3D/heterogeneous/flexibel integration technologies. Within the Department Fukushima focuses on self-assembly technologies. 'Self-assembly is the process by which an organised structure
spontaneously forms from individual components, as a result of specific, local interactions among the components,' he explains. One of these is advanced DSA. This process enables ultrafine-pitch interconnect formation through the simple coating and heating of nanocomposites with block co-polymers
and metal compounds/nanoparticles. 'DSA is a type of directed assembly which utilises the nano-phase separation of block co-polymers to create ultrafine lines, space and hole patterns, facilitating more accurate control of the feature shapes,' Fukushima outlines. 'Conventional DSA with the
block co-polymers is an alternative way to photo-patterning with photoresists that are spin-on photosensitive materials to photolithographically form fine patterns and traditionally used in semiconductor industry.' Through his advanced DSA Fukushima is able to make both ultrafine patterns
as well as form lateral and vertical interconnections with nanocomposites based on non-photolithographic methodology.
IMPLEMENTASI MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE (TPS) UNTUK MENINGKATKAN MOTIVASI BELAJAR AKUNTANSI SISWA KELAS X AKUNTANSI SMK MUHAMMADIYAH 1 PRAMBANAN KLATEN TAHUN AJARAN 2018/2019
Authors: Syafriatna Intan , Yushita Amanita Novi
Published: February 2020

Penelitian ini bertujuan untuk meningkatkan Motivasi Belajar Akuntansi Siswa Kelas X Akuntansi SMK Muhammadiyah 1 Prambanan Klaten Tahun Ajaran 2018/2019 melalui Implementasi Model Pembelajaran Kooperatif Tipe Think Pair Share (TPS). Penelitian ini merupakan Penelitian Tindakan Kelas yang dilaksanakan dalam dua siklus. Penelitian yang dilakukan terdiri dari empat tahapan yaitu perencanaan, pelaksanaan, pengamatan dan refleksi. Subjek penelitian siswa kelas X Akuntansi SMK Muhammadiyah 1 Prambanan Klaten Tahun Ajaran 2018/2019 berjumlah 23 siswa. Pengumpulan data dilakukan dengan observasi, angket dan dokumentasi. Teknik analisis data dalam penelitian ini adalah analisis data deskriptif kuantitatif dengan persentase. Hasil penelitian menunjukkan bahwa Implementasi Model Pembelajaran Kooperatif Tipe Think Pair Share (TPS) dapat Meningkatkan Motivasi Belajar Akuntansi Siswa Kelas X Akuntansi SMK Muhammadiyah 1 Prambanan Klaten Tahun Ajaran 2018/2019 yang ditunjukkan dengan adanya peningkatan persentase skor Motivasi Belajar Akuntansi berdasarkan data hasil observasi dan angket. Berdasarkan data hasil observasi, skor rata-rata Motivasi Belajar Akuntansi mengalami peningkatan sebesar 12,86% dari 74,40% pada siklus I menjadi 86,71% pada siklus II. Sedangkan berdasarkan data hasil angket, skor rata-rata Motivasi Belajar Akuntansi mengalami peningkatan sebesar 9,97% dari 73,35% pada siklus I menjadi 83,13% pada siklus II. Secara keseluruhan, persentase skor rata-rata Motivasi Belajar Akuntansi mengalami peningkatan sebesar 11,42% dari 73,75% pada siklus I menjadi 85,17% pada siklus II. Kata kunci: Think Pair Share (TPS), Motivasi Belajar Akuntansi
IMPROVING LEARNING OUTCOMES OF BASIC ACCOUNTING IN X GRADERS THROUGHT COOPERATIVE LEARNING MODELS IN JIGSAW TYPE
Authors: Wati Risa Novita , Pustikaningsih Adeng
Published: February 2020

This study aims to: find out the differences in learning outcomes of Basic Accounting in X Graders at SMK Negeri 1 Depok Academic Year 2018/2019 before and after the application of the Jigsaw Cooperative Learning Models. This research is a Quasi-Experimental study. Data collection techniques using simple random sampling for the selection of control classes and experimental classes that will be drawn randomly. The subjects of this study were students of class X AKL 1 and X AKL 3 at SMK Negeri 1 Depok. The design of data collection in this study uses the Pretest-posttest control group design model. Data analysis was performed using descriptive analysis and hypothesis testing. The results of the study are: (1) the pre-test learning outcomes in the control class obtained an average value of 71.376, the highest value of 90 and the lowest value of 50. While the pre-test scores in the experiment class obtained an average value of 71.8, the highest value of 90 and the lowest value of 50 (2) post-test learning outcomes in the control class obtained an average value of 71.433, the highest value of 83 and the lowest value of 60. While the post-test in the experiment class obtained an average of 80.733 with the highest value of 90 and the lowest value of 67. (3) Based on the results of the t-test that is 6.122 ≥ 2.00172 or tcount ttable on the results of the post-test of the experiment group and the control group, it can be concluded that there are significant differences between the results of the control class and the experiment class so that there is a significant increase the application of Cooperative Learning Models in Jigsaw type in Basic Accounting subjects to the learning outcomes of X Accounting Graders. Keywords: Jigsaw, Learning Outcomes, Basic Accounting
Comparison of Older and Younger Adults’ Attitudes Toward the Adoption and Use of Activity Trackers (Preprint)
Authors: Kim Sunyoung , Choudhury Abhishek
Published: February 2020

BACKGROUND

Activity tracking devices have significant potential in assisting older adults’ health care and quality of life, but this population lags behind in the adoption of these devices. While theoretical frameworks have been introduced to explain and increase the adoption of this technology by older adults, little effort has been made to validate the frameworks with people in other age groups.

OBJECTIVE

The goal of this study was to validate the theoretical framework of technology acceptance by older adults that we previously proposed through a direct comparison of the attitudes to and experiences of activity trackers in older and younger users.

METHODS

Semistructured interviews were conducted with 2 groups of 15 participants to investigate their experiences of using activity trackers. The recruitment criteria included age (between 18 years and 24 years for the younger participant group or 65 years and older for the older participant group) and prior experiences of using mobile devices or apps for activity tracking for 2 months and longer.

RESULTS

Our findings showed that the phase of perceived ease of learning as a significant influencer of the acceptance of activity trackers existed only in the older participant group, but this phase never emerged in the younger participant group. In addition, this study confirmed that other phases exist in both age groups, but 2 distinct patterns emerged according to age groups: (1) the social influence construct influenced the older participants positively but the younger participants negatively and (2) older participants’ exploration in the system experiment phase was purpose-driven by particular needs or benefits but for younger participants, it was a phase to explore a new technology.

CONCLUSIONS

This study confirms the validity of the proposed theoretical framework to account for the unique aspect of older adults’ technology adoption. This framework can provide theoretical guidelines when designing technology for older adults as well as when generating new investigations and experiments for older adults and technology use.
Road to Hierarchical Diabetes Management at Primary Care (ROADMAP) Study in China: Protocol for the Statistical Analysis of a Cluster Randomized Controlled Trial (Preprint)
Authors: Li Xian , Duolikun Nadila , Cheng Fengzhuo , Billot Laurent , Jia Weiping , Zhang Puhong
Published: February 2020

BACKGROUND

As the management of type 2 diabetes remains suboptimal in primary care, the Road to Hierarchical Diabetes Management at Primary Care (ROADMAP) study was designed and conducted in diverse primary care settings to test the effectiveness of a three-tiered diabetes management model of care in China.

OBJECTIVE

This paper aims to predetermine the detailed analytical methods for the ROADMAP study before the database lock to reduce potential bias and facilitate transparent analyses.

METHODS

The ROADMAP study adopts a community-based, cluster randomized controlled trial design that compares the effectiveness of a tiered diabetes management model on diabetes control with usual care among patients with diabetes over a 1-year study period. The primary outcome is the control rate of glycated hemoglobin (HbA1c) <7% at 1 year. Secondary outcomes include the control rates of ABC (HbA1c, blood pressure, and low-density lipoprotein cholesterol [LDL-C], individual and combined) and fasting blood glucose, and the change in each outcome. The primary analysis will be the log-binomial regression with generalized estimating equation (GEE), which accounts for the clustering within communities, for binary outcomes and linear regression with GEE for continuous outcomes. For both, the baseline value of the analyzed outcome will be the covariate. The other covariate further adjusted models and the repetitive models after multiple imputation (when more than 10% of observations in HbA1c after 1 year are missing) will be used for sensitivity analysis. Five prespecified subgroup analyses have also been planned to explore the heterogeneity of the intervention effects by adding the subgroup variable and its interaction with the intervention to the primary model.

RESULTS

This plan has been finalized, approved, and signed off by the principle investigator, co-principle investigator, and lead statisticians as of November 22, 2019, and made public on the institutional website without any knowledge of intervention allocation. Templates for the main figure and tables are presented.

CONCLUSIONS

This statistical analysis protocol was developed for the main results of the ROADMAP study by authors blinded to group allocation and with no access to study data, which will guarantee the transparency and reduce potential bias during statistical analysis.

CLINICALTRIAL

Chinese Clinical Trial Registry ChiCTR-IOC-17011325; https://tinyurl.com/ybpr9xrq

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/18333
Molecular characterization of ageratum enation virus and beta satellite associated with leaf curl disease of fenugreek in India
Authors: Swarnalatha P , Venkataravanappa V , Lakshminarayana Reddy C N , Sunil Kumar M , Krishna Reddy M
Published: February 2020

Cisplatn is one of the chemotherapy for the treatment of triple‐negatve breast cancer (TNBC), but its eﬀectveness is limited because of the phenomenon of chemoresistance. miR‐638 was shown to regulate chemoresistance; however, it has never been validated in the cisplatn‐resistant tumor from patents. This present study aimed to identfy the key gene regulatory networks of miR‐638 and evaluate the potental role of the miR‐638 and its targets as potental prognosis biomarkers for cisplatn‐resistance triple‐negatve breast cancer patents. The miR‐638 target was obtained from the miRecords database while the mRNA of chemoresistance biomarker candidate was obtained from the GSE18864 of GEO database, which is mRNA of cisplatn‐resistance TNBC patents. CCND1 and FZD7 are potental candidates for cisplatn chemoresistance biomarkers in patents with TNBC. Moreover, a Kaplan‐Meier survival plot showed that breast cancer patents with low mRNA levels of FZD7 had signifcantly worse overall survival than those in higher mRNA expression group. Taken together, miR‐638 plays a role in cisplatn resistance mechanism through a mechanism involving its target gene CCND1 and FZD7. Overall, miR‐638, CCND1, and FZD7 are candidates for cisplatn biomarker resistance in TNBC.
Cytoprotective activity of carrot and tomato callus extracts and the ex‐ pression of cytokines in UV‐B irradiated fibroblast cells
Authors: Rumiyati Rumiyati , Sismindari Sismindari , Semiarti Endang , Widyarani Sitarina , Sari Dewi Tika , Apritadila Brilliant Kharisma , Riastri Anami
Published: February 2020

Studies have suggested that both carrot (Daucus carota L.) and tomato (Solanum lycopersicum L.) callus extracts contain antoxidant compounds that might have the potental to protect cells from free radicals such as H2O2 that contribute to cell damage. The other sources of free radical exposure in human cells, such as UV‐B, should also be examined. UV‐B exposure can trigger increased expression of inﬂammatory cytokines such as cyclooxygenase‐2 (COX‐2) and tumor necrosis factor‐α (TNF‐α) and the antinﬂammatory cytokine interleukin‐10 (IL‐10), which causes photoaging. This study was conducted to investgate the cytoprotectve actvity of carrot and tomato callus aqueous extracts by observing cell viability using the MTT assay. Immunocytochemistry methods were used to examine the eﬀects of carrot and tomato callus aqueousextracts on the expression of COX‐2, TNF‐α, and IL‐10 in human dermal fbroblast adult (HDFa) cells exposed to UV‐B light. Carrot and tomato callus aqueous extracts were obtained by the maceraton method using aqua bidistlled solvent. Results showed that both carrot and tomato callus aqueous extracts at 0.5 mg/mL exhibited the highest cytoprotectve eﬀect in HDFa cells compared to that at other concentratons. Both carrot and tomato callus aqueous extracts could also decrease the expression of COX‐2 and TNF‐α, whereas carrot callus aqueous extract increased the expression of the ant‐inﬂammatory cytokine IL‐10 in HDFa cells.
DUAL CODE AND MACWILLIAMS IDENTITY ON ADDITIVE CODE
Authors: Yuliati Miftah , Wahyuni Sri , Wijayanti Indah Emilia
Published: February 2020

Additive code is a generalization of linear code. It is defined as subgroup of a finite Abelian group. The definitions of Hamming distance, Hamming weight, weight distribution, and homogeneous weight distribution in additive code are similar with the definitions in linear code. Different with linear code where the dual code is defined using inner product, additive code using theories in group to define its dual code because in group theory we do not have term of inner product. So, by this thesis, the definitions of dual code in additive code will be discussed. Then, this thesis discuss about a familiar theorem in dual code theory, that is MacWilliams Identity. Next, this thesis discuss about how to proof of MacWilliams Identity on adiitive code using dual codes which are defined.
ON LEFT QUASI-EXACT SEQUENCES
Authors: Muawanah Siti , Wijayanti Indah Emilia
Published: February 2020

The aim of this paper is to bring together the properties of quasi-exact sequences and homomorphism functors. It is of interest to know whether the left quasi-exact sequences have some interesting properties related to the functors and vice versa. Moreover, we also define the dualization of left quasi-exact sequences, i.e. right quasi-coexact sequences. Our proofs show that the quasi-exactness of sequences is preserved by any homomorphism functors.
Dimitrie Cantemir—A Polymath and Outstanding Personality of Romanian People
Authors: Caldare Dumitru
Published: February 2020

The present article concisely reveals the results of the thorough study of Christian concepts, reflections and educational values of Dimitrie Cantemir’s work, which are becoming currently central for modern society. The scholar demonstrated the real value of the universal national spirit, the Man-Universe correlation, and the essence of the theologico-physical concept. His philosophical system sets great store on the true knowledge of the world through the knowledge of God, and the knowledge of man as master of the world, as homo universalis. The article attaches great importance to the postulation, according to which, the philosophical consciousness in Romanian philosophy focuses on contemplation and eternity, and reason-faith correlation is a realistic foundation for the adequate elevation of human dignity. The article argues the idea that Dimitrie Cantemir’s humanism reflects the true wisdom and education of the Romanian people expressed both in the ontological-gnoseological context and in the social-political context, especially in terms of ancestry and the origin of the language. It is also conclusive that Dimitrie Cantemir’s works are oriented towards the Western system of values, towards a better, more enlightened world, and corresponding education. Therefore, western perspective is the guideline in the making of the Romanian people.
Mathematical Abilities of Preschool Children
Authors: Kvesic Ljiljanka , Brkic Slavica , Imre Anita
Published: February 2020

Regardless of the fact that people are born with innate sense of number, mathematical thinking requires certain intellectual effort for which many children are not ready. While children investigate and discover new issues in everyday life, they meet the world of mathematics although they are not aware of it. As mathematics is becoming more and more important in today’s age of technology, it is very important that children are introduced to the spells of mathematics before they start attending school, and to continue to learn mathematics with that knowledge throughout school education. As well as reading, mathematics is a subject necessary for adequate functioning in society. What is more, mathematics is a subject that develops logical thinking and perception, thus mathematical teaching of children ought to be on more accessible level than it is currently. Parents and educators have access to various games and activities that involve children into mathematical thinking and creative resolving, which develops their self-confidence.Through the research that has been conducted with both preschool and primary school children using various mathematical examples appropriate for their age, it has been found out that the children of younger age have early math skills, whereas, regarding primary school children, their later math achievement is fading over time or their conclusions are grounded upon the “expected”. The traditional way of teaching mathematics and extensive material can cause poor mathematical achievement and cause a well-known fear of mathematics.
Sarcoplasmic Proteome Profile and Internal Color of Beef Longissimus Lumborum Steaks Cooked to Different Endpoint Temperatures
Authors: Salim Ana Paula A. A. , Wang Yifei , Li Shuting , Conte-Junior Carlos A. , Chen Jing , Zhu Haining , Rentfrow Gregg , Suman Surendranath P.
Published: February 2020

The complex relationship between endpoint temperature, sarcoplasmic proteome, and internal color in cooked steaks is yet to be examined. The objective of the present study was to characterize the changes in sarcoplasmic proteome and their influence on the internal color of beef longissimus lumborum (LL) steaks cooked to different endpoint temperatures. Two 2.5-cm-thick LL steaks were fabricated from 9 beef strip loins and were cooked to an internal endpoint temperature of either 60°C (C-60) or 71°C (C-71). Cooked steaks were cooled and sliced parallel to the grilled surface, and internal color was evaluated instrumentally. Sarcoplasmic proteome from the interiors of the cooked steaks was analyzed using two-dimensional electrophoresis, and the gel images were digitally analyzed. The protein spots exhibiting more than 2-fold intensity differences (P < 0.05) were subjected to in-gel tryptic digestion and were identified by tandem mass spectrometry. The C-60 steaks demonstrated greater (P < 0.05) redness and color stability than the C-71 ones. Eleven differentially abundant protein spots were identified, and they belonged to 6 functional groups (transport proteins, enzymes in energy metabolism, chaperones, antioxidant proteins, enzymes in amino acid metabolism, and glycolytic enzymes). While 10 spots were overabundant (P < 0.05) in C-60 steaks, 1 spot was overabundant (P < 0.05) in C-71 steaks. The spot overabundant in C-71 samples was identified as myoglobin, suggesting the possible role of post-translational modifications in the heme protein’s thermal stability. The results indicated that the endpoint cooking temperature influenced sarcoplasmic proteome profile and internal color of cooked beef LL steaks. The overabundant proteins in steaks cooked to 60°C may be exploited as potential biomarkers for undercooked beef, which is a source for foodborne infections.
Структура металлоуглеродного нанокомпозита на основе пиролизатов дифталоцианинов для иммобилизации радиоактивных отходов
Authors: Байрамуков В.Ю. , Пресняков М.Ю.
Published: February 2020

Методами ПЭМ и АСМ установлено строение металлоуглеродных нанокомпозитов, полученных пиролизом дифталоцианина иттрия. Показано, что при высокотемпературном пиролизе в графитизированной углеродной матрице образуются кристаллы α-иттрия, которые на масштабах в десятки микрометров образуют развитую сеть нанокластеров. Особенности структурирования, изученные на модельном объекте, характерны для радиоактивных изотопов лантаноидов и актиноидов, создавая научную основу использования металлоуглеродных нанокомпозитов как матриц для иммобилизации высокоактивных ОЯТ.
Полосовые фильтры, произведенные с помощью системы напыления EOSS® – усовершенствованная промышленная система для напыления высококачественных оптических покрытий
Authors: Бончев Б. , Шнайдер М. , Фель И. , Никулин Д. , Васильев В.
Published: February 2020

Представлены результаты напыления различных полосовых фильтров – ИК-фильтр и тройной полосовой фильтр, полученных в установке Star.EOSS производства компании FHR. Нанесение пленок путем ионного распыления металлов в магнетронном разряде приводит к неравномерности пленок по толщине менее 0,25% (3 сигма) на подложках с диаметром от 200 до 300мм.
Enfoques de enseñanza: hacia una caracterización desde comunidades docentes de educación superior técnico profesional
Authors: González-Catalán Felipe-Ignacio
Published: February 2020

Actualmente, en la escuela de negocios de un instituto profesional en la región de Valparaíso, en Chile, se ha conformado una comunidad profesional de aprendizaje (CPA), focalizada en desarrollar una reflexión permanente en torno al proceso de enseñanza-aprendizaje, y en la alineación y mejoramiento de la docencia desde su propio diálogo. Sin embargo, no se han considerado las características propias de la docencia en el área ni la forma en que los estudiantes alcanzan el aprendizaje. Este estudio tiene por objetivo comprender el funcionamiento en la sala de clases de una CPA a partir de la caracterización de las prácticas y enfoques de enseñanza que se ejecutan en la educación superior técnico-profesional. El estudio se enmarca en una epistemología pospositivista, desde un enfoque interpretativo con alcance exploratorio, mediante la aplicación de entrevistas en profundidad y focus group, y la utilización de la técnica de análisis de contenido. Esto ha permito la generación de códigos y categorías que posibilitan la construcción de un modelo comprensivo de la docencia en esta comunidad.
Reseña del libro de Dina Beltrán López, De la utopía a la realidad, de la realidad a la utopía. La Universidad de Occidente en Sinaloa (1918-1922)
Authors: Alvarado María-de-Lourdes
Published: February 2020

De la utopía a la realidad, de la realidad a la utopía. La Universidad de Occidente en Sinaloa (1918-1922), de la pluma de Dina Beltrán López, quien a través de esta interesante investigación se propuso conocer el origen y desempeño de la Universidad de Occidente, consciente de la importancia fundamental que representa vincular el estudio de los procesos históricos de instituciones de educación superior (IES) con los problemas que las aquejan en el presente. Sin duda, la escritora considera que un sistema educativo que ignora su pasado está condenado a reproducir sus errores y frenar su desarrollo, por lo cual será incapaz de cumplir con el cometido social al que está destinado.
COMPUTATIONAL SOCIOLOGY: APPLICATION AND DEVELOPMENT
Authors: Prasetyo Yanu
Published: February 2020

Along with the popularity of research on Big Data and the increasingly massive use of computer as well as internet-based research, the development of studies with a computational sociology approach has also received more attention. Computational sociology approach such as agent-based modeling or social network analysis has become a new landmark of the interest of social scientist around the world to continue develops suitable interdisciplinary research approaches. This article makes mapping and visualizing the trends and developments of computational sociology studies through a systematic review and bibliometric analysis of scientific publications in the Scopus database. Concepts and clusters of studies on contemporary computational sociology are discussed, including international journals that have a focus and interest in this approach and research area.
THE INSTITUTIONAL EMPOWERMENT BUILDING OF THE THETHELAN (CROPS) FARMER ON REHABILITATION ZONE OF MERU BETIRI (TNMB) NATIONAL PARK IN EAST JAVA
Authors: Mulyono Joko , Baratha Lukman Wijaya , Mubarok Ahmad Munif
Published: February 2020

The study entitled “ The institutional empowerment building of the crops farmer on rehabilitation zone of Meru Betiri national park in East Java” takes the fact that since the initialization of the Ecosystem Returns (PE) in 1999 in the rehabilitation zone until the year 2017, there is no optimum result of the program. Instead of getting greener, the zone becomes more dry, arid, and wither. The problem of the study is that what causes the PE program in rehabilitation zone ran less optimum? How to build the institutional empowerment of crops farmer? The purpose of this study is to identify factors that cause the less optimum of PE program at the rehabilitation zone and to formulate the model of optimum institutional empowerment of crops farmers. The primary data were through observation, interview, and Focus Group Discussion (FGD), while the secondary data were from a mixed document of Green’s ecological theory and Nort’s institution theory. Less optimum of PE program is due to the cultural switch from abstinence to anthropocentric, the scarcity of farming land, and market intervention. The model of institutional empowerment of crops farmer is the cooperation and synergy interaction among the actors.
Formulation and Characterization of Moxifloxacin Nanoparticles with Ion Exchange Resin
Authors: Vyas Jigar , Daxini Kapil , Patel Jitendra
Published: February 2020

Moxifloxacin (MOX) is a fluoroquinolone anti-infective drug, indicated for the treatment of bacterial conjunctivitis. The drug is soluble in water but still produces low ocular bioavailability due to biological barriers and so it requires dosing for two/three times a day. The present study was designed to formulate, optimize and characterize polymeric Nanoparticles MOX for ocular administration using Ion Exchange Resin (IER). IER-nanoparticles were prepared by media milling method, formulation/process parameters were optimized based on evaluation parameters such as color of nanosuspension, sedimentation behaviour, particle size and zeta potential. MOX-IER nanosuspensions were prepared at different stoichiometric ratio of MOX and IER and characterized by entrapment efficiency, pH, particle size and zeta potential of nanosuspension. In vitro release study of optimized batch MNIER3 exhibited sustained release pattern which follows Korsmeyer-Peppas model with Fickian diffusion mechanism for drug release. Based on these results optimized batch of MOX-IER nanosuspension formulated in the laboratory was found suitable for ocular delivery.

Keywords: Moxifloxacin; nanoparticles, nanosuspension; media milling; stoichiometric ratio; sedimentation behaviour.
ENTRE O REALISMO E O TESTEMUNHO: CRÔNICAS DA VIDA OPERÁRIA, DE RONIWALTER JATOBÁ
Authors: Cabral Éderson de Oliveira , Mügge Ernani
Published: February 2020

Este artigo apresenta questões relacionadas aos conceitos de testemunho, desenvolvidas por Giorgio Agamben, e de realismo, trabalhadas por Federico Bertoni. Esses conceitos são aplicados à obra Crônicas da vida operária, de Roniwalter Jatobá, sobre a qual críticos e o próprio autor tecem considerações a partir da ótica do testemunho. Toma-se, como objeto de reflexão, tais comentários e se problematiza os efeitos do real, evidenciando que a literatura de via testemunhal é uma conexão de universos, isto é, uma intersecção entre o real e o ficcional, a qual pode ser uma chave de acesso ao pensamento crítico em relação ao universo do trabalho.

Palavras-chave: Realismo. Testemunho. Experiência. Trabalho. Roniwalter Jatobá.