bluuebunny/crossref_metadata_2025 huggingface dataset:
Computer Design, Synthesis and Hydrolytic Activity of Peptidic Artificial Ribonucleases
Authors: Lorthioir  , Truffert J.C. , Sy D. , Barbier B. , Lelievre D. , Brack A.
Published: June 2022

An RNA cleaving catalyst combined to an antisense DNA may represent a new approach for gene targeted . therapy . As cleaving agents, we used basic polypeptides under the -sheet or a.-helix conformations. Molecular modeling studies were used in an attempt to design a second generation of artificial ribonucleases, taking into account the three-dimensional arrangement of functional groups in the peptide/RNA complexes. Such computer aid in rational design processes appears as an original and promising approach .
Orthogonally Protected N-Methyl-Substituted α-Aminoglycines
Authors: Jiang Guangcheng , Simon Lajos , Rivier Jean E.
Published: June 2022

Title glycine derivatives FmocNRlCH(NR2Boc)CO2H (I; Fmoc =9-fluorenyl-methyloxycarbonyl; Boc =
Me3CO2C; Rl = H, Me; R2 = H, Me), useful as templates for the introduction of desired functionalities into
peptides, were prepared by condensation of glyoxylic acid and carbamates Fmoc-NH-Rl (Rl = H, Me), followed
by conversion with Me2CHSH of the resulting FmocNRlCH(OH)CO2H to FmocNR1CH(SCHMe2)CO2H (Rl =
H, Me) which were further treated with Boc-NH-R2 (R2 = H, Me) in the presence of N-bromosuccinimide. A simple and efficient synthesis of Fmoc-NH-Me and Boc-NH Me is also reported.
Barstar Inhibits Extracellular Ribonucleases of Streptomyces and Allows their Production from Recombinant Genes
Authors: Hartley Robert W. , Both Valentin , Hebert Eric J. , Homerova Dagmar , Jucovic Milan , Nazarov Viktor , Rybajhak Igor , Sevcik Jozef
Published: June 2022

Barstar, the intracellular protein of Bacillus amyloliquefaciens which binds to and inhibits barnase, the extracellular ribonuclease of the same organism, has been found to bind to and inhibit also the homologous ribonucleases of several Streptomyces strains. The ribonucleases of four strains of streptomyces have been produced from recombinant or synthetic genes on plasmid vectors in E. coli. Sequence identity among these enzymes is from 49% to 69%. Sequence identities to barnase are no more than 25%.
Molecular Insights on Selective and Specific Inhibitors of Cyclin Dependent Kinase 9
Enzyme (CDK9) for the Purpose of Cancer Therapy
Authors: Kumar Dileep , Karati Dipanjan , Mahadik Kaka Saheb Ramoo , Trivedi Piyush
Published: June 2022

Cyclin Dependent Kinase 9 (CDK9), which controls transcriptional elongation, is a promising pharmacological target for a variety of cancerous cells, specifically those characterized by transcriptional dysregulation. CDK9 promotes the pause or release of RNA polymerase II, a rate-limiting stage in normal transcriptional regulation that is often disturbed in cancers. New indications suggest that selective CDK9 antagonism may be beneficial in the treatment of some cancers. CDK9 modulators (inhibitors and degraders) have gotten a lot of attention recently, and many molecules are currently in clinical trials. In this review, the CDK9 antagonists under clinical and preclinical trials have been discussed, as well as the structure-activity relationship has been studied, which will help scientists generate more target-specific drug molecules in the future with less toxicity.
Natural Agents Targeting Hsp90 Co-chaperones could be Promising Candidates
for Viral Resistance Prevention
Authors: Quan Yuan , Lv Bo-Min , Zhang Hong-Yu
Published: June 2022

Viral infections have constituted a serious menace to global health. The emergence of resistant strains resulting from adaptive evolution poses a great challenge to virus control. Heat shock protein 90 (Hsp90) can shepherd virus-mutated proteins to fold into functional conformations. Therefore, inhibiting Hsp90 can block the evolution of viruses. However, none of the current Hsp90 inhibitors has been approved because of the unacceptable side effects. Considering the importance of co-chaperones for Hsp90 conformational cycle, inhibiting Hsp90 through co-chaperones may be a safe and effective strategy. Some natural agents can bind the co-chaperones to indirectly modulate Hsp90 activity with low toxicity. Besides, some of these natural agents indicate antiviral effects. Therefore, natural products are highly expected to be used as virus resistance preventives through targeting the co-chaperones of Hsp90.
Targeting Breast Cancer in Diabetic Mice Using a Combination of
Thymoquinone and Metformin
Authors: Aboulqassim Naeimah S. Sulayman , Talib Wamidh H.
Published: June 2022

Objective:

The aim of our study was to assess thymoquinone (TQ) as a combination therapy
with metformin (MT) against breast cancer in diabetic tumor-bearing mice.

Method:

The antiproliferative activities of TQ and MET and their combination were tested against
three breast cancer cell lines (EMT6/P, T47D, MDA-MB-231) using an MTT assay. We used the
isobolographic method to calculate the combination index (CI). Balb/C mice were implanted with
EMT6/P cells and diabetes was induced using Streptozotocin (STZ). The antitumor activity was
assessed for TQ and MET and their combination in vivo. The antiangiogenic activity and apoptosis
induction ability of TQ and MET were estimated using ELISA kits. To estimate the liver and kidney
functions, aspartate transaminase (AST), alanine transaminase (ALT) levels, and creatinine were
detected in serum samples using standard kits. The impact of the TQ and MET combination on reducing
blood glucose levels was measured daily using a glucometer.

Results:

Synergistic anticancer effect was observed between TQ and MET. The combination of TQ
and MET caused a significant reduction in tumor size (p value <0.05) with a high cure percentage of
(71.42%) and lower blood glucose levels. The combination therapy induces apoptosis, inhibits angiogenesis,
and causes tumor regression. Moreover, no significant effect was observed in the serum
levels of AST, ALT, and creatinine, as the values were very close to the normal ones.

Conclusion:

The combination of TQ and MET is considered a promising anticancer therapy to treat
breast cancer induced by diabetes and nondiabetes mice. This combination possesses antiproliferative
activity, anti-hyperglycemic activity, inhibits angiogenesis and induces apoptosis. Furthermore,
this combination demonstrated low toxicity.
Investigations on Force Characteristics of Orbiting Scroll in Asymmetricsuction Scroll Compressors
Authors: Sun Shuaihui , Song Zhe , Guo Pengcheng , Wang Xianwen , Zhang Bo , Mao Zhenkai
Published: June 2022

Background:

Scroll refrigeration compressors are the critical equipment for the refrigeration
system in air conditioners and vehicles. The asymmetric suction structure can be applied to reduce the
scroll compressors' size. However, the pressure difference between the symmetric working chambers
becomes larger and leads to the special force characteristics of the orbiting scroll.

Objective:

This paper illustrates the force characteristics of the orbiting scroll in an Asymmetric-suction
Scroll Compressor (ASC) to improve its stability and reliability

Methods:

The theoretical model has been established to calculate the force and moment acting on the
orbiting scroll of ASC and the Symmetric-suction Scroll Compressor (SSC) based on the transient numerical
simulation results.

Results:

The variations of gas force and moment in ASC and SSC are displayed and compared. Their
pulsation intensities are calculated and discussed.

Conclusion:

The pressure in the outer compression chamber of ASC was always higher than that in the
inner compression chamber, which caused significant discharge loss. Affected by the tangential leakage
flow, the radial force of the compressor fluctuated sharply. As the tangential force on the orbiting scroll
segments of symmetrical working chambers in ASC led to the negative spin moment, the total average
spin-torque decreased by 71.3%. Still, the pulsation intensity increased by ten times. Furthermore, the
direction of the spin moment reversed at 275°~355°, which indicated that the orbiting scroll impacted
the Oldham ring every rotation. The noise and vibration would happen, and the Oldham ring would be
damaged easily.
Building and Implementing a Quality Assurance/Quality Improvement
Program for Clinical Research
Authors: Bruns Reva , Barton-Baxter Marietta , Poskin Roxane , Kern Philip A. , Stoops William W.
Published: June 2022

Background:

A major goal of the Clinical and Translational Science Award programs is
to build and grow clinical and translational research, including the need to ensure that study teams
are educated and adhere to best clinical research practices.

Objective:

One of the primary objectives of the Center for Clinical and Translational Science at the
University of Kentucky is to help investigators implement standard operating procedures and provide
resources to conduct clinical research that is rigorous, ethical, and safe.

Methods:

The University of Kentucky Center for Clinical and Translational Science sought to establish
a Quality Assurance/Quality Improvement program for Principal Investigator (PI) initiated
clinical research studies using Center for Clinical and Translational Science services. Initiated in
2011, this program’s goal was to improve research design quality and, from the start of the project,
“find it, fix it”, leading to improved PI education without being viewed as punitive.

Results:

Since the initiation of our Quality Assurance/Quality Improvement program, PI acceptance
has been good and we have expanded its footprint and adjusted our review style to better
match the needs of our PIs. This article discusses our experiences with Quality Assurance/Quality
Improvement program development and growth.

Conclusion:

A Quality Assurance/Quality Improvement program can be developed that is efficient,
effective, educational, and well accepted by all clinical research stakeholders.
Bir Palyatif Bakım Servisi’nde Takip Edilen Tetanoz Olgusu
Authors: YAĞLIOĞLU Latife Merve , CUBUKCU Mahcube , MÜDERRİSOĞLU Seçil
Published: June 2022

Tetanoz, akut gelişen, nadir izlenen, ileri yaşlarda ölümcül seyredebilen ve nörotoksinlerle oluşan bir hastalıktır. Olgumuz, 61 yaşında, trismus, opistotonus, risus sardonicus, abdominal rijidite bulguları ile jeneralize tetanoz gelişen ve sonuçta sekel kalan erkek bir hastaydı. Olgu sunumumuz ile geçmiş aşılama öyküsü bilinmeyen, yaralanma veya mukozadan/açık yaradan yabancı cisim ile temas öyküsü olanlarda tetanoz profilaksisinin ve erişkin bağışıklamasının önemine dikkat çekmek amaçlanmıştır.
The Relationship Between The Psychosocial Health Status Of Primiparous Pregnant Women And Fear Of Childbirth
Authors: KILIÇ Süreyya , YILMAZ Sema
Published: June 2022

Aim: The prevailing opinion that the psychosocial health status of the woman during pregnancy may affect the course of pregnancy, as well as have an impact on her psychological and spiritual life. One of the factors affecting psychosocial health during pregnancy is the fear of childbirth. There are no studies in the literature evaluating the relationship between the psychosocial health status of primiparous pregnant women and the fear of childbirth. The aim of this study is to examine the relationship between the psychosocial health status of primiparous pregnant women and the fear of childbirth. Method: This descriptive study was conducted with 351 primiparous pregnant women who applied to the pregnant outpatient clinic of *** University Hospital between April 15 and August 15, 2021. The data were obtained via the Introductory Information Form, the Pregnancy Psychosocial Health Assessment Scale (PPHAS), and the Wijma Delivery Expectancy/Experience Questionnaire version A (W-DEQ) and were evaluated with descriptive statistics, Mann-Whitney U test, Kruskal-Wallis, Spearman correlation and linear regression analysis. Results: The mean age of the pregnant women participating in the study was 24.07±3.9, the mean gestational week was 31.85±4.9, the mean W-DEQ score was 66.19±23.9, and the mean PPHAS score was 3.92 ±0.46. It was determined that those who attended prenatal education classes had lower PPHAS scores (p=0.014). A negative and significant correlation was found between the total and sub-dimensions of the PPHAS and the W-DEQ scale (p<0.001). Conclusion: It was determined that as the fear of childbirth decreased, the psychosocial health levels of primiparous pregnant women increased.
The relationship between Depression, Anxiety, Stress levels and Coping Strategies and Self-Compassion of Healthcare Workers during the COVID-19 pandemic.
Authors: TÜRKOĞLU DİKMEN Sema Nur , İLKAY Şengül
Published: June 2022

Background and objectives: Previous studies have shown that stress, anxiety levels, and depressive symptoms were more common in healthcare workers than in the normal population during the COVID-19 pandemic. The aim of our study was to compare the depression, anxiety and stress levels, coping strategies and self-compassion levels of healthcare workers who had significant anxiety of transmitting the disease to their loved ones and others. Method: Our study was conducted in May 2020. The sample was consisted of 113 healthcare professionals actively working during the COVID-19 pandemic. The research scales were transferred to the electronic environment via the Google Forms program and delivered to the participants. Result: In our study, it was found that the most important reason for the anxiety of healthcare workers was to infect their loved ones. People who had significant anxiety about infecting loved ones used more functional coping strategies, had lower levels of depression, anxiety, and stress, and higher levels of self-compassion than those who did not have significant anxiety about infecting loved ones. Conclusion: It has been observed that this anxiety may have a functional effect rather than a loss of function in healthcare workers who are concerned about transmitting the disease to their loved ones. In order to protect health professionals from depression, anxiety and stress, studies should be carried out for individuals to gain self-compassion skills and functional coping strategies.
Gestión del conocimiento: big data como estructuradora de información
Authors: García Arango David Alberto , Henao Villa Federico , Aguirre Mesa Elkin Darío , Henao Villa Cesar Felipe
Published: June 2022

The term Big Data has been used for several years to refer to technologies to describe the acquisition of knowledge obtained through direct experience or perception of the real world. The intention of this research is to explore the role of data analytics as a facilitator of knowledge management. The document supports that text analysis through Big Data and the way it represents one of the most important means to visualize and analyze data, especially data that is not organized in a structured way, have a valuable meaning to optimize the management ofthe knowledge in organizational environments.
Sistema de evaluación de proyectos integradores (sepi): análisis para su implementación en la corporación universitaria americana
Authors: Mauricio Ortiz Frank , García Arango David Alberto
Published: June 2022

This article refers to an applied research project that aims to evaluate the integrative projects of the engineering faculty of the CORPORACION UNIVERSITARIA AMERICANA. The data was obtained from the same university seeking to solve in a practical way through a web platform the results management of the Project-Based Learning Strategy of the Faculty of Engineering. This platform is capable of processing the information related to the different search topics. In addition to providing information; It also has a grading system where teachers and students canobserve the corrections and progress or declarations of their projects. The implications of implementing an information system are presented to solve the problems that have to do with the evaluation of integrative projects corresponding to the faculty of systems engineering and industrial engineering within the CORPORACION UNIVERSITARIA AMERICANA(CUA).
Inhoudstafel/Table des matières
Authors: Outreach OCAD/OCAM
Published: June 2022

Inhoudstafel/Table des matières
ISIL Terrorists and the use of social media platforms: Are offensive and proactive cyber-attacks the solution to the online presence of ISIL?
Authors: Dieu Océane
Published: June 2022

Private social media platforms are entrusted today with the task of limiting the presence of terrorist groups, such as the Islamic State, on the online scene. Through mechanisms, such as a ‘notice-and-takedown’ or a removal order, these platforms are made aware of online terrorist content and consequently remove it from their platforms. However, the responsibility to protect citizens against terrorist threats lies with states and not with private companies. To reclaim this responsibility, states could perpetrate offensive and proactive cyber-attacks on devices of terrorists located in Belgium to disable their access to information to perpetrate attacks or diminish their online presence. This article discusses the legal frameworks of these mechanisms, their advantages and disadvantages and whether the Belgian state can perform such cyber-attacks or whether it would be desirable for the Belgian authorities to receive this competence. Last, several recommendations are presented to adapt the current Belgian framework to allow the perpetration of such cyber-attacks.
L'article 88quater du code d'instruction criminelle : Quelle utilité dans le cadre de la recherche dans les systèmes informatiques ?
Authors: De Borggraef Louis
Published: June 2022

Les criminels utilisent au quotidien de plus en plus les moyens ICT dans le cadre de leurs activités. Pour faire face à cette réalité, le code d’instruction criminelle offre beaucoup de possibilités aux enquêteurs. Parmi elles, figure l’article 88quater qui permet de forcer la collaboration de certaines personnes dans le cadre de la recherche non-secrète dans les systèmes informatiques. Cette disposition a récemment fait débat quant à son applicabilité à l’égard de l’inculpé. Au-delà de ce débat, certaines questions se posent au sujet de son utilité. Cet article fait le point sur cet outil controversé dans la lutte contre les infractions perpétrées avec l’aide de systèmes informatiques.
Pemanfaatan Seni Kerajinan Lakuer yang Bernilai Tradisi Lokal sebagai Kerajinan Palembang
Authors: Yani Yorinza Taska , Syarifuddin Syarifuddin* , Supriyanto Supriyanto
Published: June 2022

Kesenian merupakan salah satu produk kebudayaan yang memiliki peran sangat penting sebagai wujud dari ciri khas suatu daerah, salah satunya yakni seni kerajinan lakuer dengan ciri khasnya. Kekhasan ini muncul dari faktor sejarah, budaya bahkan alam. Dari beberapa faktor ini mempunyai peranan yang begitu penting yakni guna memperkuat adanya kerajinan yang bernilai seni yang ada di wilayah terutama indonesia. Seni kerajinan lakuer tentunya tidak diharapkan sebagai wahana untuk melestarikan budaya tradisi lokal yang ada, akan tetapi berharap menjadikan sebagai tonggak perekonomian untuk para pembuat lakuer di kota Palembang. Dalam hal ini peran pemerintah dan lembaga yang terkait sangat diharapkan, agar seni kerajinan Lakuer dapat dikembangkan sebagai seni kerajinan lokal yang bernilai jual. Lakuer adalah bahan finishing yang bertujuan untuk melapisi dan mengawetkan kerajinan yang terbuat dari kayu. Fungsi kerajinan lakuer ini yakni untuk mempercantik serta memberi nilai-nilai estetik yang ada pada produk kerajinan lakuer. Metode penelitian ini dengan menggunakan metode penelitian kulitatif jenis data berupa data primer dan sekunder. Teknik yang dipakai untuk mengumpulkan data yakni observasi, wawancara, dan dokumentasi.
IMPLEMENTASI PENUGASAN DOSEN DI SEKOLAH UNTUK PENGUATAN PENDIDIKAN KARAKTER PADA MATA PELAJARAN SEJARAH INDONESIA DI SMA 1 GOWA
Authors: Bahri Bahri , Nuraeni Nuraeni , Misnah Misnah , Riang tati Andi Dewi , Nurlela Nurlela
Published: June 2022

Integrating character education in the learning process is an effort to instill character values in students that lead to learning that not only pays attention to cognitive but also affective and psychomotor aspects. Historical subjects have an important role in character formation in students so that the values implicit in an event become very important to be integrated in learning. The implementation of character education has not yet been realized in the subjects of Indonesian history in SMA Negeri 1 Gowa because the learning models and methods used are not varied, other than that the learning tools used do not contain the character values that will be achieved at each step of learning. This leads to the inability of students to identify character values in learning history. The approach used is qualitative. While the data collection techniques used include observation, interviews and documentation. The results showed that the implementation of character education by preparing learning tools based on character education can realize character learners and be able to identify character values in historical learning material.Keywords: PDS, Character Education, Indonesian History.
Beneficial effects of RAS blockers in prediabetics with a hypertension-An observational cohort study
Authors:   Department of Pharmacology, IMS and SUM Hospital, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India, et al. Bose
Published: June 2022

Hypertensive patients have a high prevalence of prediabetes and type II Diabetes mellitus. As per International Diabetic Federation, it has been estimated that more than 470 million people will have prediabetes by 2030. Approximately 5-10% of prediabetes progresses to overt diabetes mellitus, with the same proportion converting back to normoglycemia. In patients who are on Renin-Angiotensin System [RAS] blockers either an Angiotensin converting enzyme inhibitor (ACEI) or an Angiotensin receptor blocker (ARB) would slow down the progress of prediabetic state to overt or frank diabetes mellitus. This was a prospective, observational cohort study and a total of 125 hypertensive patients with impaired glucose tolerance were included in the study who were either on ACE inhibitor or ARB monotherapy. An oral Glucose Tolerance Test (GTT) was done at baseline for screening prediabetic patients, then a periodical assessment of glycemic indices, (fasting blood sugar, 2 hr postprandial blood sugar, and glycosylated hemoglobin), lipid profile, and complication status during the study period were evaluated every 3 months for18months. At the end of 1½ years, for patients belonging to the age group 18-54 years the FBS, PPBS, and HbA1C levels decreased significantly when the RAS blocking drugs (ACEIs and ARBs) were used continuously for 1 year and then they got stabilized. The beneficial effect was seen more in the younger age group 18-54 years old patients. Male above 54 years and females above 49 were resistant to the beneficial effects. In hypertensive patients with impaired glucose tolerance, the blockade of RAS with either ACE inhibitor or ARB has a significant preventive effect on the progression of Type II DM. It may be concluded from the finding of the present study that younger hypertensive patients (18-54 years) of either sex if found to be pre-diabetic may be administered ACEI or ARB as suitable for them. The treatment should be continued vigorously for one year and then it may be maintained to continue the beneficial effect.
Meeting the Net Zero Emissions Challenge – Alphabet’s Carbon Management Actions and Opportunities
Authors:   School of Earth and Environmental Sciences, University of Queensland, Australia, Fraser Chris , Dargusch Paul ,   School of Earth and Environmental Sciences, University of Queensland, Australia, Hill Genia ,   School of Earth and Environmental Sciences, University of Queensland, Australia
Published: June 2022

The first step in managing an entity’s carbon emissions involves measurement as ‘what gets measured gets managed’ and measurement lies at the heart of carbon management. The study of carbon management is important to all stakeholders as it enables calculation of emissions that can help determine opportunities for emissions reductions to address climate change which can improve energy efficiency and brand reputation. Alphabet is an interesting company to study given its main commercial activities relate to the development and use of information technology and provision of online services. It relies heavily on online advertising for its revenue but also develops new technologies to make its operations more efficient which also have commercial applications. Also, although not directly involved in manufacturing hardware, its hardware suppliers and products generate significant emissions through their manufacturing and lifecycles. Alphabet, formerly Google, claims to have net zero emissions through carbon management by improving efficiency, purchases of renewable energy and offsets since 2007. As of 2019, their operational emissions were 5.7M t CO2e which they managed to reduce for the 3rd year in a row to zero. Alphabet will solely use carbon-free energy to power their operations by 2030 through investment in renewable energy. Furthermore, they plan to invest in renewable energy projects in regions where their suppliers operate. Carbon management and addressing climate change is a challenge to Alphabet but it also provides it with opportunities through commercialisation and expansion of their technologies. This paper contributes to the field by reviewing how Alphabet estimate and reduce their reportable emissions and, in the process, create commercial opportunities for their technologies. The paper also highlights how a limited range of emissions are reported by Alphabet.
Complex Pathology of Cardiac Syncope in Old Patients
Authors:   Cardiology Office, Marktgasse 10A, CH 4310 Rheinfelden, Switzerland, Cocco Giuseppe , Pandolfi Stefano ,   Salina Medizin AG, Roberstenstrasse 31, CH-4310 Rheinfelden, Switzerland
Published: June 2022

Syncope is characterized by a transient and rapid loss of consciousness for a short duration, with full spontaneous recovery within minutes. Syncope causes up to 2% of all emergency medical consultations. The incidence of syncope is similar in men and women, is higher in old patients (slightly higher in old women). The prevalence of syncope is up to 23% for the institutionalized elderly. In elderly patients, syncope often presents atypically, such as with falls; these patients might also have difficulty recalling events. The true incidence and prevalence of syncope in elderly patients are expected to be higher than those estimated in most studies. The causes of syncope are highly age-dependent. Reflex or neurally mediated syncope is the most common cause, particularly in younger patients. As individuals age, orthostatic hypotension and cardiac syncope become more frequent. In elderly patients, neurally mediated syncope is the most prevalent form of syncope. Orthostatic syncope is more frequent in the elderly than in young patients. In the elderly, cardiac causes account for about 15% of all cases, and in about 10% of the cases, the origin of syncope is unknown. A combination of different etiologies is common in geriatric patients because many pathophysiologies coexist, including age-related physiological changes, co-morbidities (e.g., neurological pathologies), multiple medications (with interactions, or with lowering of BP and HR), malnutrition, sarcolepsy, and prolonged bed rest. The available clinical guidelines for the diagnosis, investigation, and treatment of syncope are insufficient to address syncope in elderly patients. A comprehensive geriatric approach that considers the functional and cognitive capacities of individuals along with the medical and psychosocial aspects would be more appropriate. Modern medicine can be used to treat syncope in some geriatric patients and should be offered whenever possible.
A design theory to remove barriers to clinical information retrieval: Implementation feasibility case studies. (Preprint)
Authors: Miranda Alvet , Miah Shah J
Published: June 2022

BACKGROUND

Clinicians rely on their health organization’s knowledge services for clinical information retrieval however studies identified barriers or pain points that prevent them from accessing research from resource providers.

OBJECTIVE

Our study objective is to develop a feasible implementation design theory for health organizations to remove barriers to evidence-based clinical information retrieval, and improve Evidence-Based Practice, specifically the research evidence component.

METHODS

Literature from 2010 to 2020 was reviewed to define problems or pain points in evidence-based clinical information retrieval. Recommendations from literature are used to define purpose and scope. Design Science Research is used to complete three projects in a research stream, with the solutions evaluated iteratively and incrementally. Cloud services such as Web-Scale Discovery, Content Management System, Federated Access, Global Knowledgebase, and Document Delivery are unified as a holistic solution and evaluated using case studies by conducting in depth interviews with health sciences information managers. Frameworks and theories such as design thinking, systems thinking, and user-oriented theory of information need are adopted to construct a design theory.

RESULTS

Anatomy of a design theory is presented by developing its eight structural components to generalize results from the research stream as mature knowledge. The holistic solution’s implementation feasibility is evaluated as testable propositions to remove barriers to clinical information retrieval

CONCLUSIONS

Design theory provides practical knowledge for health sciences information managers to source existing components and integrate them as a holistic solution at their health organizations. Design theory also contributes to academic knowledge by addressing pain points and ‘call to action’ identified during literature review.
Online Diagnosis and Treatment Information Propaganda and User Self-Medication Intention (Preprint)
Authors: Wei Jianliang , Ni Yinfei , Ji Hao
Published: June 2022

BACKGROUND

At present, it is common to use online diagnosis and treatment (ODT) information for self-medication, but its internal decision-making logic is still lack of understanding and verification.

OBJECTIVE

This paper takes quality and utility dimensions of ODT information as independent variables, takes trust and perceived value as mediating variables, and then constructs a conceptual model of self-medication intention for ODT information seekers.

METHODS

This paper takes quality and utility dimensions of ODT information as independent variables, takes trust and perceived value as mediating variables, and then constructs a conceptual model of self-medication intention for ODT information seekers.

RESULTS

Based on the data analysis of 352 respondents, we have three findings: relevance of ODT information is the most important factor for trust and perceived value, even professionalism cannot play such a key role. Trust has a greater impact on self-medication intention than perceived value, where the path coefficient reaches 0.56. the influence of relevance on trust and perceived value deserves more attention than other independent variables, since the path coefficients to trust and perceived value are higher than others. Timeliness and completeness of ODT information are not close related with perceived value, while understandability has little impact on trust. Finally, suggestions including strengthening personalized recommendation of ODT information, using readily comprehensible words, and regulating online medication guidance were put forward.

CONCLUSIONS

Suggestions including strengthening personalized recommendation of ODT information, using readily comprehensible words, and regulating online medication guidance were put forward.
Delivering a Home-Based Exercise Program to Youth With Osteogenesis Imperfecta: Protocol for a Comparative-Approach Study (Preprint)
Authors: Powell Georgia , Gagnon Marianne , Komarova Svetlana , Rauch Frank , Veilleux Louis-Nicolas
Published: June 2022

BACKGROUND

Osteogenesis imperfecta (OI) is a rare bone fragility disorder associated with muscle weakness. Individuals with OI may therefore benefit from exercise interventions aiming to improve muscle and bone strength. Given the rarity of OI, many patients do not have access to exercise specialists who are familiar with the disorder. As such, telemedicine, the provision of health care through technology to provide care at a distance, may be well suited for this population.

OBJECTIVE

The main objectives are (1) to investigate the feasibility and cost-effectiveness of 2 telemedicine approaches for the delivery of an exercise intervention for youth with OI and (2) to assess the impact of the exercise intervention on muscle function and cardiopulmonary fitness in youth with OI.

METHODS

Patients with OI type I (the mildest form of OI; n=12, aged 12-16 years) from a pediatric orthopedic tertiary hospital will be randomized to receive a 12-week remote exercise intervention in either (1) a supervised group (n=6), monitored every session, or (2) a follow-up group (n=6), receiving monthly progress update appointments. Participants will undergo the following pre- and postintervention evaluations: sit-to-stand test, push-up test, sit-up test, single-legged balance test, and a heel-rise test. Both groups will be given the same 12-week exercise regimen, which includes cardiovascular, resistance, and flexibility training. For each exercise training session involving the supervised group, a kinesiologist will provide instructions to participants through live video sessions using a teleconferencing application. On the other hand, the follow-up group will discuss their progress with the kinesiologist every 4 weeks over a teleconferencing video call. Feasibility will be assessed by recruitment, adherence, and completion rates. A cost-effectiveness analysis of both approaches will be computed. Changes in muscle function and cardiopulmonary fitness will be examined between the 2 groups, pre- and postintervention.

RESULTS

It is anticipated that the supervised group will have higher adherence and completion rates compared to the follow-up group, which may be associated with greater physiological benefits; however, it may not be as cost-effective compared to the follow-up approach.

CONCLUSIONS

By determining the most feasible telemedicine approach, this study may serve as a basis for providing increased access to specialized adjunct therapies for individuals with rare disorders.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/40262
Do Culture and Religion Matter to Economic Growth?
Authors: Ramoutar Richard S.
Published: June 2022

This study offers a different empirical approach to examining the e?ects of culture and religion on economic growth using time series data for the period 1994-2020. I constructed a cultural index through the Principle Component Analysis (PCA) technique to achieve this goal. This study employs seven leading indicators from the World Values Survey (WVS) and the European Values Study (EVS) for cultural development, such as control, trust, respect, obedience, and identity. Further, the Generalized Method of Moments (GMM) system estimation was adopted. The findings confirm a significant positive impact of culture and religion on economic growth.
Violencia laboral por razón de género en el sector agropecuario de Aguascalientes
Authors: Martínez Alba María Guadalupe , Mata Zamores Silvia , Díaz Carreto Emilio , Molina Morejón Víctor Manuel , Gutiérrez Velasco Juan Ramón
Published: June 2022

Objetivo: evaluar la percepción que las trabajadoras del sector agropecuario de Aguascalientes, México, tienen de la violencia de género. Metodología: el estudio es de tipo descriptivo-transversal. Se encuestaron 75 mujeres seleccionadas de acuerdo con el método no probabilístico. Resultados: se obtuvo que 58.67% aseguró haber sido objeto o testigo de algún comentario sexista y 25.33% confirmó haber sido objeto o testigo de acoso sexual (físico o verbal) en su área de trabajo. Limitaciones: el principal obstáculo ha sido la escasez de información empírica y científica sobre estudios de violencia laboral en el sector agropecuario. Otra limitación fue que las encuestas se tuvieron que realizar de manera virtual, debido a las restricciones por la pandemia de COVID-19. Valor: se dan a conocer las desigualdades de género en un sector económico y laboral poco estudiado. Conclusiones: la información presentada demuestra que las trabajadoras detectan la violencia de género en su espacio laboral. Por eso se recomienda hacer cambios en el sector que aseguren equidad de género, seguridad y dignidad humana.
Jornaleros agrícolas migrantes y su permanencia laboral en los campos agrícolas de México
Authors: Rangel Zaragoza José Luis , Aguilar Ávila Jorge , Valdivia Alcalá Ramón , Leos Rodríguez Juan Antonio
Published: June 2022

El bienestar laboral de los jornaleros en México, históricamente, se encuentra limitado por las características del mercado de trabajo agrícola y las precarias condiciones laborales. Con la entrada en vigor del acuerdo comercial T-MEC y lo que este representa para el sector agrícola. El propósito de este trabajo es analizar los cambios en las condiciones laborales, de los jornaleros migrantes, asociados a los periodos de permanencia laboral en los centros de producción hortofrutícola, en el periodo 2009-2019. Los análisis se realizaron aplicando pruebas de dependencia y modelos multinomiales, a partir de datos provenientes de la Encuesta Nacional de Jornaleros Agrícolas (ENJO) y la Encuesta Nacional Ocupación y Empleo (ENOE). Los resultados indican la existencia de cambios significativos en las características sociodemográficas y laborales. Es decir que, hay un proceso de envejecimiento, mayor capital humano e incursión de las mujeres en actividades más precarias que los hombres. Laboralmente existe heterogeneidad en el acceso a contratos, servicio médico, y de otras prestaciones, según la estadía laboral. Este sector de la población se encuentra en el umbral de una etapa de nuevas condiciones laborales, que corresponde a las transformaciones del sector en la Política Pública y la apertura comercial.
ARTVİN ÇORUH ÜNİVERSİTESİ PERSONELİNİN PANDEMİ SÜRECİNDE FİZİKSEL AKTİVİTE VE BESLENME ALIŞKANLIKLARININ BELİRLENMESİ
Authors: SAMAR Ezgi
Published: June 2022

Bu çalışmanın amacı; Artvin Çoruh Üniversitesi personelinin pandemi sürecinde fiziksel aktivite ve beslenme alışkanlıklarının belirlenmesidir. Çalışmaya akademik (82) ve idari (41) olmak üzere toplam 123 gönüllü personel katılmıştır. Çalışmanın anket formunda 5 soru demografik özellik, 6 soru Demirezen ve Coşansu (2005) tarafından geliştirilen ‘ Beslenme Alışkanlıkları İndeksi Anketi’ ve 7 soru Öztürk (2005) tarafından geçerlik güvenirlik çalışması yapılan ‘Fiziksel Aktivite Değerlendirme Anketi’ olmak üzere 18 soru sorulmuştur. Verilerin normal dağılım gösterdiği çarpıklık (skewness) ile basıklık (kurtosis) değerleri dikkate alınarak hesaplandığından; verilerin istatistiksel analizinde parametrik testlerden bağımsız gruplar T-testi, tek yönlü varyans analizi (ANOVA) ve Pearson korelasyon analizleri kullanılmıştır. Yapılan testlerde anlamlılık düzeyi p<0.05 olarak alınmıştır. Yapılan analizler sonucunda katılımcıların fiziksel aktivite puanları ile beslenme alışkanlıkları puanları arasında istatistiksel olarak pozitif yönde düşük düzeyde anlamlı ilişkiler tespit edilmiştir (p<.05). Cinsiyet değişkenine göre fiziksel aktivite puanlarında anlamlı bir farklılık tespit edilmezken; beslenme alışkanlıkları puanlarında istatistiksel olarak anlamlı farklılık tespit edilmiştir (p<.05). Yaş, medeni durum, görev türü ve meslek yılı değişkenlerinde anlamlı bir farklılık tespit edilmemiştir (p>.05).
REKREATİF AKTİVİTELERİN KADINLARDA SERBEST ZAMAN DOYUM VE ÖZ GÜVEN DÜZEYLERİNE ETKİSİ
Authors: ALTUNTAŞ Seher Büşra , BAŞARAN Zekiye , ÇAKMAK Gökhan
Published: June 2022

İnsanlar serbest zamanlarını sevdiği, zevk aldığı, mutlu olduğu aktivitelerle değerlendirir. Doyum sağlayıcı aktivitelerin, başarıya, rahatlamaya ve öz güvene olumlu katkısı bulunur. Bu çalışmanın da amacı rekreatif faaliyetlerin serbest zaman doyum ve kadınlarda öz güven düzeyleri üzerine etkisini araştırmaktır. Çalışmanın örneklemini sportif rekreasyon etkinliklerine katılan 48 kadın oluşturmuştur. Bunlar 12 hafta, haftada üç gün ve günde 60 dakika, plates, zumba ve kardiyo çalışmasına katılmışlardır. Gruba ön ve son test olarak, kişisel bilgiler formu, serbest zaman doyum ve kadın öz güven ölçekleri uygulanmıştır. Veriler, SPSS 25.0 paket programı ile analiz edilmiştir. Yapılan normallik testi sonucunda parametrik testlerden Independent Samples T testi ve nonparametrik testlerden Wilcoxon T testi kullanılmıştır. İki değişken arasındaki ilişkiyi incelemek için Spearman's korelasyon testi uygulanmıştır. Analiz sonucunda, kadınlarda öz güven düzeylerinde artış görülürken, serbest zaman doyum düzeylerinde anlamlı farklar saptanmıştır. Serbest zaman doyum ile kadın öz güven arasında ilişki bulunmaktadır. Araştırmanın sonunda; sportif rekreasyon aktivitelerinin katılımcıların serbest zaman doyum düzeylerine olumlu etkisi olduğu ve bu etkinin de kadınlarda öz güven düzeylerini artırdığı belirlenmiştir. Bütün kadınların sağlıklı olmaları, zamanlarını iyi değerlendirebilmeleri ve özellikle de kendilerine güvenlerinin yükselmesi için rekreatif etkinliklere yönelmeleri önerilir.
Sabiedrības prasību celšana: Komerclikuma intepretācijas jautājumi
Authors:   Latvijas Universitāte, Balodis Kaspars
Published: June 2022

According to the Commercial Law of Latvia, Article 172, a limited company may bring an action against the founders, members of the board of directors or council, or the auditor, on the basis of a decision taken by a meeting of shareholders. Under certain conditions, minority shareholders who jointly represent not less than one twentieth of the equity capital may bring such an action in a court without the intermediation of the institution which, in accordance with the law, has the right to bring an action in the name of the company. Thus, a lawsuit on behalf of a company is of consequence with regard to upholding minority shareholders’ rights. This article includes a number of topical issues important to the lawsuits on behalf of a company, e. g. the legal nature of company’s lawsuit, defendants against whom these actions can be brought, legal preconditions of such lawsuits, liablity for unjustified lawsuits.
Tiesiskās paļāvības principa nozīme krimināltiesību normu piemērošanā
Authors:   Latvijas Universitāte, Leja Māris
Published: June 2022

The publication examines the impact of the principle of the protection of legitimate expectations on the understanding of the legal concept of legal error in criminal law. It argues that the prevailing view in Latvian criminal law, according to which a legal error cannot affect criminal liability, does not apply, if the following two (cumulative) conditions are met: the person believed, as a result of erroneous information by a competent authority of the State, that he was acting lawfully, even though that conduct actually met all the elements of a criminal offence; and the person had a right to rely on this information.
Personas tiesību uz brīvību aizsardzības nodrošinājums Krimināllikumā
Authors:   Latvijas Universitāte, Hamkova Diāna
Published: June 2022

The article is devoted to the analysis of the regulation on protection of person’s right to personal liberty in the Constitution of the Republic of Latvia, international legal acts and sections 152, 153 and 154 of the Criminal Law. The composition of the criminal offenses included in the above-mentioned sections of the Criminal Law, as well as the mutual delimitation of these criminal offenses on the basis of findings expressed in the doctrine of criminal law and court practice are examined in the article.
Personas mājokļa neaizskaramības krimināltiesiskā aizsardzība
Authors:   Latvijas Universitāte, Liholaja Valentija
Published: June 2022

Article 96 of the Constitution of the Republic of Latvia declares the right of everyone to the inviolability of the home which is one of the aspects of the concept of private life. Given that the right to privacy and housing is, in substance, both a prohibition of the state from interfering in private life and an obligation of the state to ensure adequate protection of a person’s privacy from undue interference, the publication aims to look at how this fundamental human right is protected by criminal law, to achieve this goal by analysing the relevant criminal law framework and its application practices.
Nevainīguma prezumpcijas nozīme un ietekme uz pierādījumu iegūšanu
Authors:   Latvijas Universitāte, Kulmanis Oskars
Published: June 2022

The understanding of the presumption of innocence has been developing since the Roman Empire. This principle and the right not to incriminate oneself are recognised as an international standard which lies at the heart of the notion of a fair procedure. The right not to incriminate oneself is significant with regard to the evidence, which is obtained through methods of coercion or oppression in defiance of the will of the accused. Since handwriting and voice samples do not exist independently from the will of the suspect, if these were to be obtained in covert or investigative measures, it is essential that the right not to incriminate oneself is respected.
Cietušā loma krimināltiesisko attiecību taisnīgā noregulējumā
Authors:   Latvijas Universitāte, Gurevičs Dāvids
Published: June 2022

In the criminal justice system, the victim is a party whose rights, including the right to redress of harm, are protected by the Constitution and general principles of law. At the same time, the victim is obliged to participate in criminal proceedings in order to provide significant facts both for the investigation and for the person who has the right to defence. Therefore, this paper examines the role of the victim in achievement of the purpose of criminal proceedings: fair regulation of criminal legal relations.
Tiešuma jēdzieniskā izpratne un nozīme kriminālprocesā
Authors:   Latvijas Universitāte, Gribonika Ērika
Published: June 2022

The principle of immediacy falls within the scope of the right to a fair trial. It is specific only to the trial stage of criminal proceedings and is considered as one of the guiding principles for ensuring respect for human rights during the trial stage of the criminal proceedings. Considering the importance of the principle of immediacy, the concept of “immediacy” is being analysed in the current article. It is designed as a doctrinal study and structured into two parts. The first part seeks to answer the descriptive question: what is the meaning and scope of the term “immediacy” in criminal proceedings? The second part outlines the limits of the principle of immediacy and the guiding motives used to determine them.
Latvijas Universitātes pirmajai Satversmei – 100
Authors:   Latvijas Universitāte, Osipova Sanita
Published: June 2022

The first Satversme of the University of Latvia (the Charter of the University of Latvia) was approved in 1922/1923. Freedom of science, which contributes to the cultural growth of the nation and ensures its stability is necessary for the development of every country. In 1922, the freedom of science was included amongst the Fundamental Human Rights of the Constitution of the Republic of Latvia draft. Although the list of fundamental rights was not approved, the freedom of science was respected in democratic Latvia. The development of the Satversme of the University of Latvia also laid the foundation for the freedom of scientific research, which was ensured both by the democratic structure of the university and by the broad guarantees for the development of scientific activity and cooperation, specified, for example, in Articles 98 and 99 thereof.