bluuebunny/crossref_metadata_2025 huggingface dataset:
Combination of lipopolysaccharide and hypoxia-ischemia attenuates cholinergic anti-inflammatory effect in newborn rat brains
Authors: Furukawa S. , Yang L. , Sameshima H.
Published: October 2020

Aim: Pharmacologic parasympathetic nerve stimulation markedly reduces brain damage in a newborn rat model of hypoxia-ischemia (HI). Our aim is to determine whether a brain-protective effect can be achieved by parasympathetic nerve stimulation even with the synergy effect of lipopolysaccharide (LPS) and HI. Study design: 7-day-old Wistar rats were used. Rats received intraperitoneal administration of LPS which was followed by left carotid artery ligation. After a two-hour recovery period rats were placed in a hypoxic environment (8% oxygen) for 1 hour. Carbachol, used as an acetylcholine receptor agonist, or saline was injected subcutaneously immediately prior to one-hour hypoxia to determine its neuroprotective effect. Seven days later, the degree of brain damage in the ligated side of the hemisphere was compared to that in the contralateral hemisphere, which acts as reference. The relative difference in hemisphere area ((ligated side/non-ligated side) × 100%) was employed as an indicator of brain damage. Microglial aggregation (cells/mm 2) on the cortex and cytokine production in the ligated side of the hemisphere were also evaluated. Results: Three pups died in the carbachol group. There was no significant difference in brain damage between the saline (n = 34) and carbachol (n = 30) groups (86.0 ± 12.1% vs. 90.8 ± 13.6%, respectively). There was no significant difference in microglial aggregation between the saline and carbachol groups (155.7 ± 201.1 cells/mm2 vs. 89.8 ± 149.1 cells/mm2, respectively). IL-1β production in the saline and carbachol groups was 1.8 ± 1.2 pg/dL and 1.8 ± 1.1 pg/dL, respectively, with no significant difference between the groups. Conclusion: Combination of LPS and HI attenuates cholinergic anti-inflammatory effect in newborn rat brains.
Analysis and discussion of high-risk factors in nine cases of uterine scar combined with complete uterine rupture
Authors: Zhou X.Y. , Li K.X. , Shu X.M.
Published: October 2020

Objective: This study aims to investigate the high-risk factors, clinical characteristics, and outcomes of complete uterine ruptures in patients with uterine scars. Methods: The data of nine patients with complete uterine ruptures, who were admitted to Huaian First People's Hospital from January 2015 to December 2017, were retrospectively analyzed. The general information of these patients and courses of treatment were summarized. Results: Among these nine patients with complete uterine ruptures, the induction of labor induced uterine rupture in four patients, placenta implantation induced uterine rupture in one patient, an unknown factor induced uterine rupture in one patient (with a history of artificial abortion), scar rupture occurred after laparoscopic cornual surgery in one patient, and the incision scar of a previous cesarean section ruptured after labor contractions in two patients. Rupture position: Rupture of the uterine body occurred in three patients, rupture of the uterine base occurred in one patient, rupture of the uterine horn occurred in one patient, and scar rupture at the previous incisions at the lower segment of the uterus occurred in four patients. The clinical manifestations were persistent abdominal pain in two patients, irregular lower abdominal pain in four patients, and no obvious abdominal pain in two patients. Six patients had complications with vaginal bleeding, while three patients had no vaginal bleeding. Seven patients underwent uterine rupture repair, while two patients underwent a subtotal hysterectomy. Among the five patients without induced labor, one patient had intrauterine fetal death, while the remaining four patients had good outcomes for newborns. Conclusion: Patients with a cesarean scar pregnancy, who underwent another pregnancy, suffer a high incidence of uterine rupture. The induction of labor with rivanol and misoprostol, placenta previa, multiple cesarean sections, multiple artificial abortions, and a history of gynecological uterine surgery are all high-risk factors for scar uterine pregnancy.
Detection of group B streptococcus colonization in cervical and lower vaginal secretions of pregnant women
Authors: Wang Y.X. , Zhong M. , Yi H. , He H.F.
Published: October 2020

Objective: To examine the efficacy of cervical and lower vaginal secretions in the detection of group B streptococcus (GBS) colonization in women in early and late pregnancy. Materials and Methods: Two-thousand women in early pregnancy (8-12 weeks of gestation) aged approximately 27 years who visited our outpatient clinic from December 2016 to December 2018 were enrolled. Cervical and lower vaginal secretions were obtained at 8-12 weeks (early pregnancy) and then at 37 weeks (late pregnancy) of gestation and screened for GBS infection. Patients were classified as follows: (i) cervical and lower vaginal secretions were GBS-positive (group A), (ii) only cervical secretions were GBS-positive (group B), (iii) only lower vaginal secretions were GBS-positive (group C), and (iv) both cervical and lower vaginal secretions were GBS-negative (group D). Results: No difference in the GBS-positive rate was observed between women in early and late pregnancy. The GBS-positive detection rate was lower in women from which cervical secretions were screened than that in women from which lower vaginal secretions were assayed; however, the incidence rates of adverse pregnancy events, such as abortion, preterm delivery, premature rupture of membranes and neonatal infection, were higher in women in which cervical secretions were assayed. Conclusion: Women in early pregnancy should be screened for GBS infection using cervical secretions.
Thyroid stimulating hormone (TSH) level variations in early pregnancy and feto-maternal outcome; retrospective study
Authors: Al-Husban N. , Hababeh A. , Al-Kasasbeh M. , Odeh R. , Shaheen M. , Moughrabi D. , Zabalawi D.
Published: October 2020

Introduction: Thyroid disease is the second most common endocrine disorder affecting women of reproductive age. The debate continues which TSH levels need to be considered as a reflection of subclinical hypothyroidism in pregnancy. Our aim was to find out if variations in the level of thyroid stimulating hormone (TSH) in early pregnancy of women not known to have thyroid disease or anti-thyroid antibodies were linked to different fetomaternal outcomes. Materials and Methods: Retrospective comparative study that compared group 1 (TSH level 0.1-1.99 mIU/L) and group 2 (TSH level 2.0-4 mIU/L). Each group was further subdivided into primigravidae and multipara with a total of 1527 pregnant women included in the study. Results: The body mass index (BMI), was statistically higher in primiparous women in group 2 (P2) than primiparous in group 1 (P1), (mean BMI 28.0 vs. 26.9, respectively, P value 0.014). The odds ratio of miscarriage in the primigravidae in group 2 was 1.24. This was not statistically significant (95% confidence interval; 0.42-3.63). The miscarriage rate was not also statistically different between multipara (odds ratio 1.04, 95% CI 0.6-1.7). For the primigravid groups, the odds of developing gestational diabetes mellitus was significantly higher in group 2 than in group 1 (Odds Ratio = 2.6, 95% CI 1.2-5.4). This was not seen in multiparous women. This difference could be explained by the higher BMI in group 2. There was a significant difference in the mean arterial blood pressure in multipara between the 2 groups. Although the values of the mean blood pressure (85 and 84 mmHg) were close, the P-value of the t-test performed was 0.007 possibly due to the difference in variance and sample size of each group. There were no statistical difference in the mean gestational age at delivery, preterm birth, mode of delivery and birth weight of term and preterm deliveries. Conclusions: In singleton pregnancies of women without thyroid dysfunction and with negative anti-thyroid antibodies, variations of the TSH level in early pregnancy up to 4.0 mIU/L were not associated with a significant difference in most of the fetomaternal outcomes. TSH values between 2.0-4.0 mIU/L were found to be associated with gestational diabetes in primigravid women and higher mean arterial blood pressure in multiparous women.
Robotic laparoendoscopic single-site surgery for concurrent hysterectomy and cholecystectomy
Authors: Na E.D. , Choi S.H. , Park H.
Published: October 2020

With the quality ergonomics and rapid learning curve of the robotic surgery system taken into consideration, robotic laparoendoscopic single-site surgery (R-LESS) appears to be the best integration for maximizing the benefits of single-site surgery. However, there are drawbacks of robot-assisted procedures which include longer operative time and higher cost, because of this, we hypothesized that the burden of robotic surgery would be reduced if two surgeries could be completed within one session in R-LESS. Three cases of R-LESS were performed for combined hysterectomy and cholecystectomy in patients with concomitant benign uterine disease and cholecystopathy. The combined surgeries were successfully conducted without additional port insertion or conversion and included the benefits of decreased hospital stay, anesthesia risk, and cost compared with the sum of two separate surgeries. Therefore, in cases in which concomitant pathologies are detected in the abdominopelvic cavity, R-LESS can be an option for selected patients with the benefit of minimally invasive surgery.
Preterm labor in mild carbon monoxide poisoning: a case report
Authors: Han S. , Choi S. , Nah S. , Lee Y.H.
Published: October 2020

Introduction: Carbon monoxide (CO) is a common toxic gas, and CO poisoning in pregnant women can be particularly dangerous, as the fetus is more vulnerable to CO exposure. Even if the mother experiences only mild symptoms and has low carboxyhemoglobin (COHb) levels following exposure, fetal COHb levels can be much higher. Therefore, there is no clear consensus for defining mild CO poisoning during pregnancy. Here, we report a case of preterm delivery following mild CO intoxication. Case report: An 18-year-old female at 36 weeks of gestation visited the hospital with CO poisoning 1 h after exposure. She had only mild headache and COHb level was checked 3.9%. Hyperbaric oxygen (HBO2) therapy was not provided because she and her husband refused this treatment. Consequently, normobaric oxygen therapy was initiated. Five hours later, her symptoms improved, and thus, the therapy was discontinued. Eight hours later, the patient experienced labor pain, and the baby was delivered by spontaneous vaginal delivery. Neonatal COHb was 1.3% at birth, and the newborn was healthy. Conclusion: If maternal symptoms are mild following low CO exposure, normobaric oxygen therapy or HBO2 therapy can be considered. However, whatever we choose, we should be prepared for premature birth.
Addressing optimal maternal weight and exercise during the preconception period and pregnancy
Authors: Moutos C.P. , Lozovyy V. , Clark S.M.
Published: October 2020

Pregnancy is an opportunity for women to access the healthcare system and address their health needs. Before and during pregnancy, providers should emphasize assisting women in interventions aimed at establishing a healthy weight and exercise regimen and should tailor their guidance based on a woman’s baseline level of fitness. Doing so will improve a woman’s likelihood of pregnancy and improve outcomes if she does become pregnant. Our goal is to propose actions providers should take to improve a woman’s understanding of and ability to manage her weight and exercise goals during the preconception and pregnancy periods.
Relationship of Heart Rate, Perceived Exertion, and Intra-Abdominal Pressure in Women
Authors: Wolpern Ali E. , de Gennaro Johanna D. , Brusseau Timothy A. , Byun Wonwoo , Egger Marlene J. , Hitchcock Robert W. , Nygaard Ingrid E. , Sheng Xiaoming , Shaw Janet M.
Published: October 2020

Background: Exercise increases intra-abdominal pressure (IAP) acutely, which may impact the pelvic floor of women. IAP during exercise demonstrates high variability among women but is not routinely assessed. Assessing less invasive measures related to IAP during exercise may facilitate study of how IAP impacts the pelvic floor.

Methods: The objective of this study was to investigate the relationship of heart rate and rating of perceived exertion (RPE) with IAP during a standard treadmill test. We describe the trend of IAP by predicted aerobic fitness during incremental exercise. IAP was measured using a validated transducer placed in the upper vagina. Heart rate and RPE were collected during the first 3 stages of the standard Bruce treadmill protocol. Relationships of heart rate and RPE with IAP were determined by Pearson correlation coefficients. Predicted aerobic fitness values for each participant were ranked in tertiles with IAP by treadmill stage.

Results: Twenty-four women participated in this study (mean age: 24.7 ± 5.4 years; body mass index: 22.5 ± 2.2 kg·m−2). There were significant relationships between heart rate and IAP (r = 0.67, P < 0.001) and RPE and IAP (r = 0.60, P < 0.001) across treadmill stages. Tertiles of predicted aerobic fitness and IAP displayed similar trends as other exercise measures such as heart rate and ventilation during incremental exercise.

Conclusion: Heart rate and RPE could be used as proxy measures of IAP during incremental exercise. Aerobic fitness may help explain IAP variability in women and provide context for future research on IAP and pelvic floor health.
Observasi lingkungan didesa gantarang
Authors: Dinasti Sarmila Dwi
Published: October 2020

Kuliah kerja lapang plus (KKLP) merupakan suatu kegiatan perkeluliahan yang bersifat intrakulikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu.oleh karena,sifatnya intrakulikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strarta satu (SI) harus mengikuti KKLP.
PEMBINAAN TPA/TPQ DI DESA BONTOMATE'NE KEC. TURATEA KAB. JENEPONTO
Authors: Mubaraqah Ikhwan
Published: October 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh masyarakat dalam waktu tertentu. oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (SI) harus mengikuti KKLP.
Seminar program kerja di desa gantarang
Authors: Dinasti Sarmila Dwi
Published: October 2020

Kuliah kerja lapang plus (KKLP) merupakan suatu kegiatan perkeluliahan yang bersifat intrakulikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu.oleh karena,sifatnya intrakulikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strarta satu (SI) harus mengikuti KKLP.
Is Vegetation Cover in Key Behaviour Settings Important for Early Childhood Socioemotional Function? A Preregistered, Cross-sectional Study
Authors: Mygind Lærke , Elsborg Peter , Schipperijn Jasper , Boruff Bryan , Lum Jarrad , Bølling Mads , Flensborg-Madsen Trine , Bentsen Peter , Enticott Peter Gregory , Christian Hayley
Published: October 2020

The environmental influences on early childhood development are understudied. The association between vegetation cover (i.e. trees, shrubs, grassed areas) in four key behaviour settings and socioemotional functioning was investigated in 1196 young children (2-5 years). Emotional difficulties were inversely associated with vegetation cover in the home yard (OR: 0.81 [0.69-0.96]) and neighbourhood (OR: 0.79 [0.67-0.94]), but not in early childhood education and care (ECEC) centre outdoor areas or the ECEC neighbourhood. The higher odds of emotional difficulties associated with lower levels of maternal education was reduced with higher percentages of home yard vegetation cover. There was no evidence of mediation of the relationship between emotional difficulties and vegetation cover by time spent playing outside the home, day or nighttime sleep duration, or physical activity. We found no associations between vegetation cover and conduct, hyperactivity and inattention, peer difficulties, or prosocial behaviours.
Dampak IT terhadap hubungan antara strategi dan kinerja perusahaan
Authors: syam muhammad alvin arkananta
Published: October 2020

Artikel ini membahas tentang bagaimana Teknologi Informasi bisa mempengaruhi UKM dalam meningkatkan peluang pasarnya dengan cara Orientasi Strategis dan Kinerja perusahaan UKM itu sendiri
PEMBINAAN TPA/TPQ DI DESA BONTOMATE'NE KEC. TURATEA KAB. JENEPONTO
Authors: Rahayu
Published: October 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh masyarakat dalam waktu tertentu. oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (SI) harus mengikuti KKLP.
Data analytics in supply chain management
Authors: Wicaksono Hendro
Published: October 2020

The presentation discussed the impact of the technologies related to the 4th industrial revolution on big data. The 4th industrial revolution ecosystem is characterized by the presence of smart PPR (Product, Process, and Resource) who generates data. It transforms the product-based business model to product-data-driven service model. Big data also exist due to the digital transformation of supply chain management processes. Data analytics and machine learning can improve the supply chain management processes, such as demand forecasting, production, strategic sourcing, etc. Finally, the presentation gives some examples of the application of data analytics in real companies.
English Worksheet for Second Grade (Greeting & Parting) by Adib Rifqi Setiawan
Authors: Setiawan Adib Rifqi
Published: October 2020

English Worksheet for Second Grade (Greeting & Parting) by Adib Rifqi Setiawan
Laporan minggu keempat kegiatan pertama
Authors: asniar
Published: October 2020

Kuliah Kerja Lapang Plus (KKLP) Merupakan suatu Kegiatan Perkuliahan yang Bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang di lakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP
Tugas Resensi Jurnal Bukti Keilahian Yesus Menurut Injil
Authors: Salendur Jonathan Hizkia Hosea
Published: October 2020

Keilahian Yesus merupakan inti dari iman Kristen. Prinsip ini seringkali diragukan oleh banyak kalangan. Tulisan ini bertujuan untuk memegang bukti-bukti yang kuat dan meyakinkan tentang keilahian Yesus menurut pemberitaan keempat Injil; Matius, Markus, Lukas dan Yohanes. Metode penulisan yang digunakan adalah analisis biblikal terhadap ungkapan Yesus sebagai Allah dengan mendasarkan pada teks di dalam keempat Injil. Hasil temuan memperlihatkan ada banyak teks dari keempat Injil yang mengindikasikan keilahian Yesus.
Resensi Jornal Bukti Keilahian Yesus Menurut Injil
Authors: Sinabariba Daniel Irwanto
Published: October 2020

Keilahian Yesus merupakan inti dari iman Kristen. Prinsip ini seringkali diragukan oleh banyak kalangan. Tulisan ini bertujuan untuk menunjukkan bukti-bukti yang kuat dan meyakinkan tentang keilahian Yesus menurut pemberitaan keempat Injil; Matius, Markus, Lukas dan Yohanes. Metode penulisan yang digunakan adalah analisis biblikal terhadap uangkapan Yesus sebagai Allah dengan mendasarkan pada teks di dalam keempat Injil. Hasil temuan memperlihatkan ada banyak teks dari keempat Injil yang mengindikasikan keilahian Yesus.
Monotonous driving induces shifts in spatial attention as a function of handedness
Authors: Chandrakumar Dilushi , Coussens Scott , Keage Hannah AD , Banks Siobhan , Dorrian Jill , Loetscher Tobias
Published: October 2020

Current evidence suggests that the ability to detect and react to information under lowered alertness conditions might be more impaired on the left than the right side of space. This evidence derives mainly from right-handers being assessed in computer and paper-and-pencil spatial attention tasks. However, there are suggestions that left-handers might show impairments on the opposite (right) side compared to right-handers with lowered alertness, and it is unclear whether the impairments observed in the computer tasks have any real-world implications for activities such as driving. The current study investigated the alertness and spatial attention relationship under simulated monotonous driving in left- and right-handers. Twenty left-handed and 22 right-handed participants (15 males, mean age=23.6y, SD=5.0y) were assessed on a simulated driving task (lasting approximately 60 minutes) to induce a time-on-task effect. The driving task involved responding to stimuli appearing at six different horizontal locations on the screen, whilst driving in a 50km/h zone. Decreases in alertness and driving performance were evident with time-on-task in both handedness groups. We found handedness impacts reacting to lateral stimuli differently with time-on-task: right-handers reacted slower to the leftmost stimuli, while left-handers showed the opposite pattern (although not statistically significant) in the second compared to first half of the drive. Our findings support suggestions that handedness modulates the spatial attention and alertness interactions. The interactions were observed in a simulated driving task which calls for further research to understand the safety implications of these interactions for activities such as driving.
Measurement of Human Stress: A Multidimensional Approach
Authors: Dorsey Achsah , Scherer Elissa , Eckhoff Randy , Furberg Robert
Published: October 2020

Stress is a multi-dimensional construct that is comprised of exposure to events, perceptions of stress, and physiological responses to stress. Research consistently demonstrates a strong association between stress and a myriad of physical and mental health concerns, resulting in a pervasive and interdisciplinary agreement on the importance of investigating the relationship between stress and health. Developing a holistic understanding of stress requires assessment of the three domains vital to the study of stress: 1) the presence of environmental stressors, 2) psychological and biological reactions to stressors, and 3) the length of time over which the stressor or stress response occurs. Self-reports allow for subjective evaluations of stress that illuminate the duration and severity of the psychological response to stressors. Biomarkers, in turn, capture a more objective measure of stress and create a deeper understanding of the biological response to chronic and acute stress. Finally, the use of digital biomarkers allows for further exploration of the physiological fluctuations caused by stress by measuring the changes occurring at the same time as the stressor. Future research on stress and health should favor a multi-dimensional approach that creates a triangulated picture of stress, drawing from each of the three aforementioned method groups.
Modern Constitutional Law: Russian and Foreign Studies
Authors:   INION RAN
Published: October 2020

The collection contains articles, reviews and abstracts that reveal trends in the development of constitutional law and international constitutionalism, constitutional problems of the social state, the constitutional identity and territorial configuration of power in Russia, the values and shortcomings of the Constitution of the Russian Federation in 1993, and the features of constitutional reforms in foreign countries. The issues of the formation the human rights of the new generation and the impact of digital technologies and artificial intelligence on the development of democracy are shown. For researchers, teachers, postgraduates and students.
Constitutional law in the XXI century and the transformation of modern law
Authors:   INION RAN, Konyukhova Irina
Published: October 2020

The article reveals the dialectics of the development of constitutional law in the conditions of the transformation of law in the XXI century. Two general trends in the development of law - globalization and differentiation of law, manifested in the formation of branches of law of the new generation, its internationalization, humanization and socialization are considered. Attention is drawn to the fact that the crisis of liberal democracy has caused the increasing importance of the axiology of law.
THE TERRITORIAL CONFIGURATION OF POWER IN THE RUSSIAN FEDERATION (THE PROBLEMATIC ISSUES OF DOCTRINAL UNDERSTANDINGS AND CONSTITUTIONAL-LEGAL REGULATION
Authors: Nekrasov Sergei
Published: October 2020

The constitutional principles of the Federal structure and local self-government during the quarter-century period of the Constitution of the Russian Federation have not undergone a serious transformation. Nevertheless, through the current legislative and other legal regulation, the constitutional model of the territorial organization of public power in the Russian state has been seriously modified: the structure of the Russian Federation is changing, new levels of state administration (sub-Federal, sub-regional) are emerging, the status of special administrative-territorial units is being formalized, there is an excessive centralization of local self-government. Not all trends appear to be unambiguously positive and suggest the need of further scientific understanding and discussion.
History of world Indology in modern historiography
Authors:   INION RAN, Gordon Alexander
Published: October 2020

The reason for the article was «History of Indian History» by Leonid Alaev. The book poses several general theoretical questions about the importance of historiography as a «self-reflection» of historical science, the relationship between historical knowledge and historical consciousness. It focuses on the impact on the scientific process of political interests and the search for national identity, which determines the difference of individual national schools. The author of the book shows that for all the differences of the latter, the common logic of the scientific process, which is represented by the folding and evolution of Indology as a world scientific discipline, breaks through the road.
From East / West to Global Historiography
Authors:   INION RAN, Gordon Alexander
Published: October 2020

The article considers the historiographical situation in the world science, the exhaustion of the heuristic potential of the traditional East/West binary opposition and the displacement of its new West / Rest. The formation of «global historiography» is traced, its cultural and historical prerequisites in the origin of the discipline «general history» in Russia are revealed. At the same time, the initial assumptions of the anti-globalist trend in modern historiography, associated with the search for national identity, are revealed. It is noted the appeal of conservative Russian thought to the Byzantine heritage, to the spiritual potential of Asian societies.
Epidemics and the changing world order: China and its perception by Western observers in the context of global history
Authors:   INION RAN, Mikhel Dmitriy
Published: October 2020

The article is analyzed the place of China in a context of a global history of epidemics, representations of the western observers about the reasons of occurrence of dangerous infections in territory of this country, and changing role of China within the limits of a changing world order. The long period of history from the outbreak of the bubonic plague in Hong Kong in 1894 to the pandemic of coronavirus infection that began in late 2019 in Wuhan is considered. In the context of the global history of epidemics, China was long perceived as having poor governance mechanisms. In the first two decades of the 21th century, China confidently became a country with a powerful economy and an efficient administrative and political system. The article concludes that the current world crisis, which symbolizes this pandemic, will not only strengthen China's position on the international arena, but will contribute to changing the world order, where China will take its place as one of the main centers of power in the XXI century.
Comparison of tumor surface marking by experienced neurosurgeon versus neuronavigation guidance
Authors: Nepal Pankaj Raj , Rijal Suman
Published: October 2020

Introduction: Accurate flap marking has always been a challenge for neurosurgeons during tumor surgery. The use of neuronavigation has somewhat overcome this problem by allowing the navigation of intraoperative 3D neuroanatomy of the lesion. In this study, we aim to evaluate the percentage discrepancy of tumor surface marking by experienced neurosurgeon versus neuronavigation guidance.

Methods: This is a prospective analytical study. Initial surface marking of the tumor was done by experienced neurosurgeon on the basis of sagittal, coronal and axial Magnetic Resonance Imaging films; and later was re-marked using neuronavigation. Photographs of surface markings were taken then comparison was done by plotting marking on the standard graph paper and percentage discrepancies were calculated for every case.

Results: Percentage discrepancy ranged from 15 % to 81 % and the mean discrepancy score was 44%.

Conclusion: Even in experienced neurosurgeon's hand, flap marking is not always accurate and neuronavigation definitely seems to be an effective tool.
Solitary spinal metastasis of renal cell carcinoma and en-bloc resection-A case report
Authors: Karmacharya Balgopal , Yogi Nikunja , Bhattarai Aabishkar , Bhandari Anjali , Bhandari Prabin , Pun Benju Tilija
Published: October 2020

Renal Cell Carcinoma is a challenging condition for clinicians because of its poor response to radiotherapy, chemotherapy and even immunotherapy. Spine is the second most common site of metastasis and is also an indicator of poor prognosis. There is a significant dilemma for brain and spine surgeons about when to undergo aggressive surgical treatment, such as en-bloc resection of oligo-spine metastasis compared to conventional tumor excision by curettage. Here, we report a case of 60-year old female, a diagnosed case of renal cell carcinoma who had undergone right sided nephrectomy (with adrenalectomy) 5 years ago. She presented with history of pain over upper back. MRI revealed metastatic lesion over the thoracic T-7 vertebra. She underwent en-block total vertebral resection and reconstruction with titanium cage and pedicle screw fixation of the T-7 vertebra which healed with good results.
Antileishmanial Steroidal Alkaloids from the Plant Sarcococca wallicii Stapf
Authors: Adhikari Achyut , Vohra M Ismail
Published: October 2020

Available with fulltext.
Comparative Study of Structure, Morphology and Thermal Properties of Allo and Cotton Fibers on Chemical Modification
Authors: Bhandari Netra Lal
Published: October 2020

Available with fulltext.
Micelle Formation in Myristyltrimethyl Ammonium Bromide at Different Solvent Composition of Ethanol Water Mixed Solvent Media
Authors: Shrestha Prem Kumar , Mitruka Jaya Narayan , Chapagain Subash Kumar
Published: October 2020

Available with fulltext.
Samoocena młodych uczestników pełnomorskich rejsów a różne realizacje Szkoły pod Żaglami
Authors: Romaniuk Miłosz Wawrzyniec
Published: October 2020

The paper presents the results of research on the level of self-esteem of participants of high seas cruises that implement the idea of sail training and are a non-standard form of informal education. The study involved 124 people, including 65 girls and 59 boys aged 13 to 18 years old, who can be considered as youth with special educational needs. They were participants of the Krzysztof Baranowski School Under Sails in 2015 and 2016, the cruise of the 42nd General Secondary School in Warsaw in 2016 and the Catholic School Under Sails in 2017. The results show a statistically significant increase in the level of self-esteem measured with the SES scale. The level of self-esteem of participants after the cruise is significantly higher than that of their peers from standardisation groups. It can be assumed that various types of Schools Under Sails are an attractive way to educate young people.
State support for small and medium-sized businesses in modern conditions
Authors: Nesterova Svitlana , Kopcha Veronika , Myhalchinets Halyna
Published: October 2020

The subject of the research. The study focuses on the theoretical and practical aspects of the problems facing State support for small and medium-sized enterprises in Ukraine. The purpose of the article is to identify the main destructive factors in the development of medium and small enterprises and to identify ways to overcome them. The methodological basis of the article is general scientific and special methods of scientific knowledge, such as dialectical method, analysis, grouping of data, problem-oriented approach. Results of work. The article discusses the special role of medium- and small-scale enterprises in generating GDP, creating jobs and improving the demographic situation. It is noted that a significant proportion of enterprises either operate in the shadow sector or do not take measures to improve profitability. It has been hypothesized that an important reason for this state of affairs is imperfect state support for small and medium-sized enterprises. First of all, there is a heavy tax burden, low wages in the sector, unstable legislation. The worldwide coronavirus pandemic has also been noted as an additional challenge, with most small and medium-sized businesses on the verge of survival through quarantine activities. The field of application of results. The materials, results and conclusions of the article may be used in the activities of various public organizations and local self-government bodies as an analytical basis for appeals about the need for State support for small and medium-sized enterprises, Training of specialists in secondary and higher education. Conclusions. Small and medium-sized businesses are the driving force behind the economy. It provides a large share of GDP, promotes the development of the middle class and has a positive impact on demographic indicators. The opportunity and ability of small and medium-sized enterprises to develop, even under difficult political and economic conditions, proves that it is these entities that support the economy in difficult times. Creating an enabling environment for doing business and developing small and medium-sized enterprises should therefore be a priority for the Government. To this end, support programs must be put in place: infotrmation, financial security and social support. Active and targeted support for the development of small and medium-sized enterprises contributes to the growth of GDP and the creation of new jobs.
Civil society as an element of ukrainian state democracy
Authors: Shimchenko Ljudmila
Published: October 2020

The subject of research is the phenomenon of civil society under democratic development state. The goal of research is to study the state of functioning of civil society under democratization of state-building processes. The research target is to consider civil society as a phenomenon of uniting people to defend their interests; to examine the role of civil society in democratic development state. Research methods. In the process of the study, the following research methods were used: a search method, synthesis and generalization. The results of work. The analysis of the value orientations of Ukrainian society has shown that the value of the public good has not become widespread among the Ukrainian population, that is dangerous for achieving unity to bring Ukraine to a higher level of development and citizens to a more better living standard. It has been found that the formation of civil society can increase the level of public good only in terms of the rapid development of a democratic system of state. The field of application of results. The results of this research can be applied to teach such disciplines as Fundamentals of Democracy and Human Rights, Legal State and Civil Society, Political Studies. Conclusions. The main positive result of transformation of Ukraine is civil society. The activity of the formation civil society process is a consequence of value changes, extending legal opportunities of the Ukrainian population and growing demand of society for justice and integrity. Civil society, in all its manifestations, is associated with the hope of organizing such social life that would provide the possibility of civilizational modernization.
The role of Ukrainian local budget expenditures on health in conditions of decentralization
Authors: Lysiak Liubov , Kachula Svitlana , Abdin Alina
Published: October 2020

Relevance of the research topic. The implementation of medical reform in Ukraine, which provides radical structural changes in the health care system, the transformation of financing mechanisms for services, and at the same time the implementation of budgetary reform, an integral part of which is budget decentralization, makes the issue of assessing the role of local budget spending on health care. Formulation of the problem. In conditions of limited budgetary funds, growing debt and budgetary decentralization, successful implementation of health care reform is impossible without increasing the role of local budgets in financing the industry of development priority areas. Analysis of recent research and publications. The works of I. Chygynova, V. Makogon, M. Pasichnogo, Ju. Markuts, I. Kogut, Y. Pasichnik, V. Tropina [1-6] and others are devoted to the study of issues related to the problems of the article. The results of their own research of some of the indicated problems are presented in [6-8]. Segregation of unexplored parts of a common problem. In the context of deepening budget decentralization, strengthening the financial base of local budgets, expanding the functional powers of local governments, it is necessary to further search for ways to increase the role of local budgets in health care financing. The purpose of the article is to assess the role of expenditures of local budgets of Ukraine on the health care sector in the context of deepening budget decentralization and to develop proposals for improving its financing. Duringresearch, general scientific and special methods were used: analysis and synthesis, the method of generalization, statistical, etc. The article analyzes and evaluates the total expenditures of local budgets for health care, as well as for the regional program "Health of the population of the Dnipropetrovsk region for 2020-2024". The attention is focused on increasing the role of local budget expenditures in the process of changing the health financing model. The basis for expanding the capacity of local governments to finance health care was the deepening of budgetary decentralization, changes in the distribution of taxes to local budgets, etc. Conclusions. In conditions of acute limited financial resources, success in the formation and effective use of funds from local budgets of Ukraine for the development of an appropriate health care system is associated, first of all, with the consistent implementation of the financial and budgetary policy of the state, the coherence of medical and budgetary reforms, priorities, increasing the efficiency of the use of budgetary funds in format of target program budgeting. The results of this study can be applied in the process of forming and implementing social and budgetary policies for the development of the health care system in the country.
Problems and prospects of human potential development in rural areas of Ukraine
Authors: Ivanyshyn Volodymyr , Bialkovska Oksana
Published: October 2020

The subject of the research is theoretical and practical aspects of the formation, development and growth of human potential in rural areas of Ukraine. The purpose of the work is to identify the problems of forming the human potential of rural areas of the country and substantiate strategic guidelines and promising areas and means of solving them to ensure its growth and sustainable development. Methodological basis of the article is the use of modern theoretical provisions of the economy of the national economy, rural territories, the reproduction of human potential; General scientific and special methods of knowledge: demographic, statistical-economic, economic-mathematical, graphic. Results of work. It is determined that the human potential of rural areas of Ukraine is formed by demographic factors, employment and employment, income level, quality and social and environmental conditions of life. However, it is the narrowed natural reproduction, high unemployment and low incomes of rural residents that cause its deterioration and degradation. It is found that these and other problems should be solved by implementing state programs to support rural fertility, developing alternative activities and increasing employment, social and environmental development of rural areas. The field of application of results. The conclusions and suggestions of the article can be used by local governments, rural communities, public organizations, charitable foundations in solving problems of human development in rural areas, educational and scientific institutions in educational and scientific activities. Conclusions. Financial sources for the implementation of proposals can be monetary and other resources of agricultural enterprises, rural residents, rural communities, targeted state programs, public organizations and charitable foundations. Public-private partnership, social responsibility, social innovation, information and digital technologies should be used as tools for achieving these goals. When determining priorities for implementing these measures in practice, it is necessary to take into account the specifics of each locality, the region where they are located, as well as the decisions of rural communities. This will contribute to the revival of rural areas, increase the prestige of rural life, preserve the rural way of life, expand the reproduction of human capital and personal growth of human potential.
Strategic guidelines for the development of management of sports organizations in Ukraine
Authors: Іhnatenko Mykola , Irtyshcheva Inna
Published: October 2020

The subject of the research is the theoretical, methodological and practical basis for the formation of the content and functions of sports management, achieving efficiency and strategic guidelines for its development in the future. The purpose of the work is to determine the content, functions, technologies and effectiveness of management in the field of physical culture and sports and to analyze the existing directions of foreign management in order to justify the strategic guidelines for the development of sports management in Ukraine. The methodological basis of the article is both general scientific and special methods of scientific knowledge. Methods were used: historical, dialectical, monographic, system-structural analysis and synthesis of economic comparisons, expert assessments, graphic. Result of work. The article identifies sports management as the management of sports organizations. Its features, main functions and their content are revealed. Strategic guidelines for the management of sports organizations for the future are defined, taking into account the experience of foreign countries. They are aimed at ensuring mass availability of physical culture and sports, affordability of their services, introduction of innovations in the process of providing and implementing management, and development of related activities. Scope of the results. The conclusions and results of the article can be used in the scientific and educational process of economic faculties, faculties of physical culture and sports of higher education institutions; in the management and activities of institutions and organizations of physical culture and sports. Conclusions. Physical culture and sports are much more than events with sports records, victories and medals, which retain their appeal for many. Sport is presented as a joy that brings physical activity to millions of people with a huge number of volunteers and qualified personnel. After all, the main principle of "sport for all" and its management is to ensure access to sports and physical exercise for all social strata and groups of the population, regardless of their racial, ethnic and cultural affiliation, their place in the system of industrial and labor relations, social status and income, and property and social status in General.
Formation of XBRL reporting
Authors: Umantsiv Нalyna , Polovyk Yevheniia
Published: October 2020

Relevance of the research topic. At the present stage of transformational transformation of the economy, the issue with the use of the XBRL format in Ukraine, which is a prerequisite for successful interaction of enterprises in the global financial market and enhancing the competitiveness of domestic enterprises. Problem statement. The absence of the practice of applying taxonomy of financial statements in Ukraine, causes the relevance of this study. The developed countries of the world have already introduced this format, because it allows to make the reporting not only transparent and accessible to potential investors, but also convenient for analysis. Analysis of recent studies and publications. The process of functioning of the financial reporting system in the format XBRL is the newest, it was researched in works: Kuznetsova S. A., Borisenko A. A., Boyko R. V., Ostrovskaya O. A., Khatib E., Yassin M., Harber M., Marx B., De Jager P. and other. Highlighting unexplored parts of a common problem. Particular attention is needed to develop solutions that will minimize potential problems associated with the implementation and use of the XBRL format in Ukraine. Setting of the task, objectives of the research. Analyzing the implementation of XBRL format in Ukraine. Identifying prospects for using and setting the potential issues in the preparation of new financial statements using global experience. Research method or methodology. Dialectical methods of scientific cognition, collection and analysis of information and inductive method were used in the course of the research. Basic material presentation (results of work). The article defines the essence of the XBRL format, analyzes the stages of its implementation in Ukraine. Prospects and typical errors in the preparation of financial statements using the format have been identified. Measures have been developed to minimize the likelihood of occurrence and to overcome problems associated with its application, taking into account world experience. Areas of application of the results. The results of this study may be applied in the preparation of financial statements in accordance with the specified format. Conclusions to the article. All of the benefits of implementing XBRL far outweigh the impact of its application Its use in Ukraine shall allow reporting entities to properly prepare financial statements, adjust the requirement for duplicating financial statements while presenting to regulators, and help woo investors through formation of the qualitative financial statements.