bluuebunny/crossref_metadata_2025 huggingface dataset:
Proximate Composition of some Indigenous Plant Species having Ethno-medicinal Importance
Authors: DAS SIMANTA , KANDALI RANJAN , BAISHYA SAMINDRA
Published: April 2023

The present investigation was intended to study the phytochemical composition as well as juice characteristics of seven plant samples viz. S. cumini L., S. fructicosum Roxb. DC., Basella alba L., Basella rubra L., R. indica L., R. damascena Mill. and R. bracteata J.C. Wendl. collected from different places of Jorhat district, Assam, India. R. indica L., R. damascena Mill. and R. bracteata J.C. Wendl. of Rosaceae family was found with higher ascorbic acid content (139.84mg/100g, 142.72 mg/100g and 120.93 mg/100g) as well as total phenolic content (1516.52 mg GAE/100g, 1380.67 mg/100g and 1347.23 mg GAE/100g). Fruits of Basella rubra L. had higher total flavonoid content (292.52 mg QE/100g) followed by fruits of Basella rubra L. (262.88 mg QE/100g) and flowers of Rosa bracteata J.C. Wendl. (196.12 mg QE/100g). Fruits of S. cumini L. are found to be rich in anthocyanin content (124.87 mg/100g) as well as total ash (1.84%) and minerals like phosphorus (32.53 mg/100g), sodium (96.24 mg/100g), calcium (142.36 mg/100g) and potassium (252.44 mg/100g). Higher iron content (4.37 mg/100g) was quantified in fruits of Basella rubra L.
Scalability Benchmarking of Cloud-Native Applications Applied to Event-Driven Microservices
Authors: Henning Sören
Published: April 2023

Cloud-native applications constitute a recent trend for designing large-scale software systems. This thesis introduces the Theodolite benchmarking method, allowing researchers and practitioners to conduct empirical
scalability evaluations of cloud-native applications, their frameworks, configurations, and deployments. The benchmarking method is applied to event-driven microservices, a specific type of cloud-native applications that
employ distributed stream processing frameworks to scale with massive data volumes. Extensive experimental evaluations benchmark and compare the scalability of various stream processing frameworks under different
configurations and deployments, including different public and private cloud environments. These experiments show that the presented benchmarking method provides statistically sound results in an adequate amount of time.
In addition, three case studies demonstrate that the Theodolite benchmarking method can be applied to a wide range of applications beyond stream processing.
Momentary Self-esteem as a Process Underlying the Association Between Childhood Trauma and Psychosis: Experience Sampling Study
Authors: Daemen Maud , van Amelsvoort Therese ,   GROUP investigators, Reininghaus Ulrich
Published: April 2023

Background

Exposure to childhood trauma is associated with an increased risk of developing and maintaining psychotic symptoms later in life. Self-esteem might be an important psychological process underlying the association between childhood trauma and psychosis, but there is only limited evidence to support this claim, especially in daily life.

Objective

In this study, we aimed to investigate whether exposure to childhood trauma (physical, emotional, and sexual abuse and physical and emotional neglect) moderates the cross-sectional and temporal associations between self-esteem and psychotic experiences in patients with psychotic disorders, their first-degree relatives, and controls.

Methods

We assessed momentary self-esteem and psychotic experiences in daily life using the experience sampling method in 139 patients with psychotic disorders, 118 first-degree relatives of patients with psychotic disorders, and 111 controls. Childhood trauma was measured using the Childhood Trauma Questionnaire. We fitted linear mixed models and added two-way and three-way interaction terms to test the hypotheses.

Results

The association between momentary self-esteem and psychotic experiences in daily life was modified by prior exposure to high versus low levels of several types of childhood trauma, that is, physical (χ22=24.9, family-wise error-corrected P<.001) and sexual abuse (χ22=15.9, P<.001) and physical neglect (χ22=116.7, P<.001). Specifically, momentary self-esteem was associated with more intense psychotic experiences in patients exposed to high versus low levels of physical neglect, in relatives exposed to high versus low levels of physical abuse, and in relatives and controls exposed to high versus low levels of sexual abuse. When investigating temporal order, the results showed no evidence that childhood trauma modified the temporal associations between self-esteem at tn-1 and psychotic experiences at tn or those between psychotic experiences at tn-1 and self-esteem at tn.

Conclusions

The association between self-esteem and psychotic experiences in daily life was found to be stronger in those exposed to high versus low levels of several types of childhood trauma (ie, physical abuse, sexual abuse, and physical neglect).
Platform-Based Patient-Clinician Digital Health Interventions for Care Transitions: Protocol for a Scoping Review
Authors: Backman Chantal , Papp Steve , Harley Anne , Tonjock Kolle Aurelie , Visintini Sarah , Shah Soha , Berdusco Randa , Poitras Stéphane , Beaulé Paul E , French-Merkley Veronique
Published: April 2023

Background

With the increased adoption of technology, the use of digital health interventions in health care settings has increased. Patient-clinician digital health interventions have the potential to improve patient care, especially during important transitions between hospital and home. Digital health interventions can provide support to patients during these transitions, thereby leading to better patient outcomes.

Objective

This scoping review aims to explore the available literature, specifically (1) to examine the impact of platform-based digital health interventions focused on care transitions on patient outcomes, and (2) to identify the barriers to and enablers for the uptake and implementation of these digital health interventions.

Methods

This protocol was developed based on Arksey and O’Malley’s, Levac and colleagues’, and JBI scoping review methodologies, and it has been reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement for the Scoping Reviews) format. The search strategies were developed for 4 databases: MEDLINE, CINAHL, EMBASE, and the Cochrane Central Register of Controlled Trials by using key words such as “hospital to home transition” and “platform-based digital health.” Studies involving patients 16 years or older that used a platform-based digital health intervention during their hospital to home transition will be included in this review. Two reviewers will independently screen articles for eligibility by using a 2-stage process (ie, title and abstract screening and full-text screening). We expect to refine the eligibility criteria during the title and abstract screening process as we anticipate retrieving a significant number of articles. In addition, we will also perform a targeted search of the grey literature, as well as data extraction. Data analysis will consist of a narrative and descriptive synthesis.

Results

The review is expected to identify research gaps that will inform the development of future patient-clinician digital health interventions. We have identified a total of 8333 articles. Screening began in September 2022, and data extraction is expected to commence in February 2023 and end by April 2023. Data analyses and final results will be submitted to a peer-reviewed journal in August 2023.

Conclusions

We expect to find a wide variety of postcare interventions, some gaps in the quality of research evidence, as well as a lack of detailed information on digital health interventions.

International Registered Report Identifier (IRRID)

PRR1-10.2196/42056
US Presidential Awards: An Outcomes Analysis
Authors: Oppenheimer Steven , Evans-Bye Dominique , Berman Mindy , Chun Helen , Lundgren Alvalyn , Miller Terri , Tuason Orenda
Published: April 2023

Around 99% of U.S. Presidential Awards for mentored student research in science go to college level mentors like Steve Oppenheimer. We have an opportunity here to describe the research and mentorship outcomes of two US Presidential Awardees. One is Steve and the other is a high school teacher, Dominique Evans-Bye, who also achieved a US Presidential Award for mentored student research in science. Dominique is one of only about two at the high school level, of hundreds in decades given at the college level. Because of the rarity of high school Presidential award winners, we show here what can be done at the high school level. And we show how vastly different, yet similar, university and high school programs can be. We believe that this paper is the only one ever to explore university and high school mentored student research in one place. We also review high school student research from the New Journal of Student Research Abstracts and show that it is sometimes every bit as good as university level research and should be considered an important part of the U.S. research effort. This may be the first time such a statement has been made. This review from our lab should help others understand what goes into a U.S. Presidential Award, the highest White House mentoring award in the nation, administered by the National Science Foundation. The important accomplishments of Dominique will help high school and middle school teachers enhance their student research programs if they choose to do so. Motivation is key.
CHALLENGES OF EFFECTIVE ASSESSMENT OF ONLINE LEARNERS
Authors: Qafzezi Eriola , Kadi Fabiola
Published: April 2023

Educators at all levels are paying attention to ever challenging demands of teaching across distance. One of the most debatable issues in this respect remains assessment. This paper aims to address some challenges of effective assessment of online learners. Some valuable insights will be provided with reference to summative and formative assessment. The article also introduces some important skills to be possessed by learners of the twenty-first century, supported by examples of online assessment activities that support such skills and correspond to the realities of online learning. Continuous reference will be made to students’ feedback as a way of assessment in and for learning. Throughout the article assessment is considered as an essential element to support the continuous evolution of online learning.
Forecasting Future Sales of Bigmarts
Authors: Rao P Srinivasa
Published: April 2023

Abstract: In this contemporary era, supermarket and general stores have been scrutinizing the sales record for knowing the demands of customers and to find the straggles in general trend. So, as the data is available a predictive model has been built using various algorithms such as Polynomial regression, XGBoost, Linear regression, and Ridge regression techniques for forecasting the sales of a business in advance. The prediction is based on sales of supermarket for various outlets to calibrate the business model to expected outcomes. With the results and analysis provided by the model retailers can know the sales volume in advance
ON THE QUESTION OF THE CRITERIA FOR COVERING THE PROBLEMS OF REVOLUTION AND COUNTER-REVOLUTION IN RUSSIA
Authors:   Российский государственный университет правосудия, Москва, Россия, Зарианна Владимировна Cоломко
Published: April 2023

The relevance of the theme is seen in the fact that in the post-Soviet period there was a blurring of the criteria for scientific reconstruction and assessment of the problems of revolution and counter-revolution in Russia. The purpose of the work is to provoke a critical reflection on the methodological and ideological turn that has taken place. According to the author, the reverse side of the restoration of the conservative and right-wing liberal historical-legal and theoretical-legal discourse was the unrea-sonable rejection of the principles of dialectical thinking in the works of post-Soviet authors and, as a result, the reideologization of the historical-legal sphere of academic knowledge. The idea is substantiated that the modern scientific optics of understanding the problems of revolution and counter-revolution in Russia should include not only a specific understanding of the essence of the prerevolutionary system (dependent peripheral capitalism), but also an assessment of the confrontation between the revolutionary movement and the tsarist regime from the point of view of a concretely understood social ideal. The first steps of this ideal in historical practice are reflected in the images of high culture.
Genetic Polymorphism of IFNA1 and IFNAR1 Genes in Covid-19 Iraqi Patients
Authors:   raqi Center for Cancer and Medical Genetic Research, A. Almukhtar Asmaa , M.Ali Amal ,   raqi Center for Cancer and Medical Genetic Research, A.Mahmood Noah ,   raqi Center for Cancer and Medical Genetic Research
Published: April 2023

Coronavirus disease 2019 (Covid-19) is a deadly acute respiratory illness brought on by an infection with coronavirus 2. (SARS-CoV-2).The severity of the syndrome was variant among the individuals ranging between severe and mild. Interferons type 1 are one of the cytokines inactive the viral replication. Genetic variation inrs2850015 for IFNA1 and rs202055606 for IFNAR1 were investigated by high-resolution melting analysis. Results showed that TT genotype and T allele of rs20205560 6polymorphism represented a significant positive odds ratio as risk factor for severity while C allele act as protective factor. The rs2850015 polymor phismrevealed conversionT to G,the GG genotype and G allele represented a significant positive odds ratio as risk factor for severity while the T allele represent protective factorfrom severity. It wasbe concluded that the GG geno type and G allele for rs2850015 and TT genotype and T allelemay be associated with severity of Covid-19
Absorptive Capacity and Technology Spillovers: A Quantile Regression Approach
Authors: Mohamad Yunus Norhanishah
Published: April 2023

Employing a quantile regression estimator, the study presents new evidence on the role of human capital in exploiting the technology effects from foreign direct investment (FDI) in low-technology industries. A new model of human capital to capture the non-linearity of FDI effects according to employees’ educational qualifications was developed. This study examined whether workers’ absorptive capacity had different effects on FDI spillover at different points of conditional distribution. Although the study found that the ability of employees with degrees and diplomas to exploit foreign technology exceeds the median quantile, it also acknowledges the existence of both ‘over-skilled’ and ‘over-educated’ workers at a higher quantile of FDI distribution. As the problem of shortages and mismatch between skills and education for workers with degrees and diplomas still hinders firms from applying advanced technologies from FDI, this study proposes using the law to make firms work with universities. Firms could inform universities of the industry’s in-demand skills regularly and get involved in the development of the university curriculum to ensure that graduates are equipped with skills and knowledge that can be ‘transmitted’ to different industries.
Does Tourism Lead to Environmental Impact? Cross-National Static and Dynamic Evidence from the Ecological Footprint
Authors: A. Jaz Nur Ameera , Habibullah Muzafar Shah , Wan Ngah Wan Azman Saini , Kaliappan Shivee Ranjanee
Published: April 2023

At present, public consciousness on respecting and safeguarding the environment is declining rapidly. On that note, this study assumes that growing tourism has negative environmental implications. To satisfy tourism demand, overconsumption, and overexploitation through the development of tourism-related facilities have generated waste that destroy ecosystem functions. Ecological footprint is used to study the environmental impact of tourism activities by including the role of governance in our model. The outcome reveals that the environment is significantly affected by tourism pressure and good governance is essential for environmental protection.
The Type of “Full-Size” Comedy in Fielding’s Work
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Chesnokova Tatiana G.
Published: April 2023

Among the variety of forms, presented in Fielding’s dramatic work, regular 5-act comedy takes a special place. The plays of this kind, produced by the writer, were not a great success in the theatre (with the exception of his adaptation of The Miser from Molière). Their reputation with critics was not the best either and for the most part still remains such. By all accounts his special gift as a playwright was most clearly displayed in his theatrical “burlesques” and “satires” (from The Author’s Farce to Pasquin and The Historical Register for the year 1736), while the future novelist’s regular plays remained a vague copy of the Restoration comedies, with incoherent inclusions of sentimental moralism. Without claiming to re-evaluate the comparative merits of Fielding’s “short” and “large” drama, the author of the article stresses the fact that regular 5-act comedies were not a mere incident in the writer’s work and in the highest degree satisfied his conscious artistic ambition. Not being content with the success of his short plays, Fielding repeatedly came back to the large comedic form contradictorily related to the group of irregular comic genres (alternately approaching and maintaining a distance from them). The evolution of Fielding’s “full-size” comedy proves it to be an indispensable link in the development of English comedy from Restoration to Sheridan and onward to the late flourish of the art of comedy on the edge of its classical forms (particularly in O. Wilde’s work).
STRATEGI PENGEMBANGAN USAHA INDUSTRI HANDYCRAFT PADACENDERAMATA ROTAN DI KELURAHAN TONDO KECAMATAN MANTIKULORE KOTA PALU
Authors: Saputri Riski Oktavia , Muis Abdul , Sulmi Sulmi
Published: April 2023

Indonesia merupakan penghasil rotan terbesar didunia, hampir 85% pasokan rotan dunia berasal dari Indonesia. Rotan dapat dimanfaatkan sebagai bahan baku pabrik, industri atau Home Industry, misalnya untuk pembuatan kerajinan perabot rumah tangga dan lain-lain. Tujuan penelitian yaitu menentukan strategi pengembangan usaha industri Handycraft cenderamta rotan Kelurahan Tondo Kecamatan Mantikulore Kota Palu. Penelitian ini dilaksanakan di industri

Handycraft cenderamata rotan di Kelurahan Tondo Kecamatan Mantikulore Kota Palu pada bulan Oktober sampai Desember 2021. Metode penelitian yang digunakan dalam penelitian ini adalah menggunakan analisis SWOT dengan mengidentifikasi faktor internal (Strenght dan Weakness) dan faktor eksternal (Opportunities dan Threats). Penentuan sampel ditentukan secara sengaja (purposive), jumlah sampel sebanyak 5 orang terdiri dari pemilik usaha Handycraft

cenderamata, karyawan, konsumen dan pesaing. Berdasarkan hasil analisis data yaitu diketahui pada analisis SWOT didapatkan total skor IFAS sebesar 1,80 dan total skor EFAS sebesar 2,73 hal ini menunjukkan bahwa industri Handycraft cenderama rotan berada padaposisi sumbu kekuatan (Strenght) dan peluang (Opportunities) yakni kuadran 1 artinya industri Handycraft cenderamata rotan disarankan untuk melakukan strategi progresif yaitu memanfaatkan kekuatan (Strenght) internal untuk mendapatkan keuntungan dan peluang (Opportunities) eksternal untuk mencapai pertumbuhan bisnis yang meningkat.
A Data Assisted Prediction of Fatigue Life for Aluminum Alloys Using Machine Learning Approach
Authors: S Allamaprabhu Ani , Deoghare A.B.
Published: April 2023

The article presents a machine learning (ML) model capable of
recognizing the effect of physical and chemical parameters that
contribute to fatigue failure in aluminium alloys. The traditional
method of obtaining S-N curve is both expensive and time-consuming. The
mechanism of fatigue is complex and influenced by a number of factors.
The current study proposes a data-driven method to estimate fatigue life
at different stress amplitudes that form the S-N curves. The influencing
factors dominating the fatigue life can be effectively integrated using
Machine Learning techniques to predict S-N curves of aluminium alloys.
Dataset was prepared from industrially accepted references. MLP and GBR
algorithms were employed to train the model. The prediction of fatigue
life had a MSE of 0.46. It is interesting to note that the prepared
model could recognize the features that most affected the fatigue life
and predict the S-N curve which had close agreement with the
experimental data. The current study intends to assist material
scientists and design engineers to investigate the influence of
different alloying element compositions on fatigue life. The model can
be employed to obtain a preliminary estimate of fatigue life resulting
from varying alloy mixtures.
The Influence of Interpersonal Relationships and Disability Acceptance on Self-Esteem of Unemployed Disabled People and The Mediating Effect of Self-Efficacy: Multiple Group Comparison Analysis of Disability Degree
Authors:   Korean Academy of Integrated Care Management, Heo se-mi , Lee ye-na
Published: April 2023

This study aimed to identify important factors affecting employment and willingness to work for the unemployed disabled people. The effect of interpersonal relationships and disability acceptance of employed disabled people on self-esteem and the mediating effect of self-efficacy were verified. A multi-group comparison was conducted to analyze the difference according to the degree of disability (severe and mild). For the data analysis, the 2nd wave 6th data of the employment, a panel survey for the disabled was used. Among the economically inactive population, 1,579 panelists who responded to the main variables of this study were analyzed. The results of this study were as follows. First, the self-esteem of unemployed disabled people was directly affected by their interpersonal relationships and disability acceptance and indirectly affected by self-efficacy. Second, the effect of interpersonal relationships on self-efficacy was greater in people with severe disabilities than in people with mild disabilities. Based on the research results, programs and policies on disability acceptance, interpersonal relationships, and self-efficacy improvement were proposed to improve self-esteem.
Einleitung: Verschwörungserzählungen
Authors: Baratella Nils , Bauer Alexander Max , Grass Helena Esther , Kornmesser Stephan
Published: April 2023

Verschwörungserzählungen sind ein fortdauernd prominentes Thema in der nachrichtlichen Berichterstattung und treten immer wieder in Zusammenhang mit Bewegungen auf, die demokratische Strukturen zu untergraben versuchen. In der aktuellen Diskussion um Verschwörungserzählungen dominieren psychologische, politische, kultur- und sozialwissenschaftliche Perspektiven. Philosophische Zugänge hingegen scheinen dabei unterrepräsentiert zu sein. Der hier vorliegende Schwerpunkt „Verschwörungserzählungen“ soll einen Beitrag dazu leisten, diesem Mangel abzuhelfen, und das Phänomen der Verschwörungserzählungen aus verschiedenen Perspektiven insbesondere der Praktischen Philosophie zu beleuchten.
Verschwörungserzählungen im Kontext der Wissenschaftsleugnung
Authors: Heichele Thomas
Published: April 2023

Der Aufsatz untersucht aus wissenschaftstheoretischer Warte Verschwörungserzählungen im Kontext der Wissenschaftsleugnung und stellt sowohl diesbezügliche Merkmale als auch angemessene Kritikverfahren heraus. Zu diesem Zweck werden zu Beginn die jeweiligen Charakteristika von Wissenschaft und Pseudowissenschaft herausgearbeitet. Daran anschließend wird Wissenschaftsleugnung als eine spezifische Form der Pseudowissenschaft vorgestellt, bei der es sich losgelöst von den Kriterien legitimer Kritik um ein Bestreiten wissenschaftlichen Wissens handelt. In diesem Zusammenhang werden sieben Strategien der Wissenschaftsleugnung erläutert und mit den rational begründeten Methoden zur Erlangung wissenschaftlicher Überzeugungen kontrastiert. Als eine der sieben Taktiken werden Verschwörungserzählungen im nächsten Schritt einer gesonderten Analyse unterzogen. Hierbei findet eine Explikation der in diesem Zusammenhang relevanten Begriffe „Verschwörung“, „Verschwörungserzählung“ und „Verschwörungstheorie“ statt, die sich als operationalisierbar für Anwendungen mit Blick auf Verfahren der Wissenschaftsleugnung erweist. Im Anschluss daran werden zehn Begründungsstrategien unplausibler Verschwörungserzählungen erarbeitet und mit den Methoden der Wissenschaftsleugnung in Verbindung gesetzt. Den Schluss bildet ein Anriss praktischer Herausforderungen, die eine interdisziplinäre Zusammenarbeit erfordern, wobei noch einmal die besondere Rolle der Philosophie bei der Bewältigung der Gefahren einer Kultur des Postfaktischen betont wird.
Plasma Insulin Concentration in Newborns and Children and Age at Menarche
Authors: Wang Guoying , Radovick Sally , Buckley Jessie P. , Hauser Russ , Williams Paige L. , Hong Xiumei , Pearson Colleen , Adams William G. , Wang Xiaobin
Published: April 2023

OBJECTIVE

To investigate the association of plasma insulin levels and their trajectories from birth to childhood with the timing of menarche.

RESEARCH DESIGN AND METHODS

This prospective study included 458 girls recruited at birth between 1998 and 2011 and followed prospectively at the Boston Medical Center. Plasma nonfasting insulin concentrations were measured at two time points: at birth (cord blood) and in childhood (age 0.5–5 years). Age at menarche was obtained from a pubertal developmental questionnaire or abstracted from electronic medical records.

RESULTS

Three hundred six (67%) of the girls had reached menarche. The median (range) age at menarche was 12.4 (9–15) years. Elevated plasma insulin concentrations at birth (n = 391) and in childhood (n = 335) were each associated with an earlier mean age at menarche: approximately 2 months earlier per doubling of insulin concentration (mean shift, −1.95 months, 95% CI, −0.33 to −3.53, and −2.07 months, 95% CI, −0.48 to −3.65, respectively). Girls with overweight or obesity in addition to elevated insulin attained menarche about 11–17 months earlier, on average, than those with normal weight and low insulin. Considering longitudinal trajectories (n = 268), having high insulin levels both at birth and in childhood was associated with a roughly 6 months earlier mean age at menarche (mean shift, −6.25 months, 95% CI, −0.38 to −11.88), compared with having consistently low insulin levels at both time points.

CONCLUSIONS

Our data showed that elevated insulin concentrations in early life, especially in conjunction with overweight or obesity, contribute to the earlier onset of menarche, suggesting the need for early screening and intervention.
Multifocal Cutaneous Leishmaniasis: a New Clinical Presentation of the Disease
Authors: Maniscalco Mario , Noto Giuseppe , Zichichi Leonardo , Veraldi Stefano
Published: April 2023

This article does not have an abstract.
Acute Papulopustular Rosacea-like Eruption from Oral Parabens
Authors: Hagman Johanna H. , Ginebri Agnese , Piemonte Paolo , Frascione Pasquale
Published: April 2023

This article does not have an abstract.
Unusual Presentation of Trichoadenoma in an Infant
Authors: Hyun Lee Ji , Young Kim Yoon , Yeong Yoon Sun , Deuk Lee Jeong , Hyun Cho Sang
Published: April 2023

This article does not have an abstract.
Potential Utility of the Tumour Marker RCAS1 for Monitoring Patients with Invasive Extramammary Paget's Disease
Authors: Yoshida Yuichi , Koga Kaori , Watanabe Tessin , Koga Monji , Takahashi Akira , Nakayama Juichiro , Yamamoto Osamu
Published: April 2023

This article does not have an abstract.
Patient’s Estimation of Efficacy of Various Hyperhidrosis Treatments in a Dermatological Clinic
Authors: Amini Mohammad , Harmsze Ankie M. , Tupker Ron A.
Published: April 2023

Hyperhidrosis is a common ailment, which is accompanied by a low quality of life. There are many current treatment options. The aims of this study were to investigate: (i) the characteristics of sweating in patients referred for hyperhidrosis; (ii) their quality of life, using the Dermatology Life Quality Index and the Hyperhidrosis Disease Severity Scale; and (iii) their estimation of efficacy of the treatments given, using a patient’s global assessment score and the quality of life scores. In 47 of 94 patients (50%) responding to the questionnaires, hyperhidrosis was confined exclusively to the axillae. In 21 (22%) of the patients, sweating in the axillae was combined with sweating of the hands and/or feet, face or other, more widespread, regions. Fifteen patients (16%) had generalized hyperhidrosis. In half of all cases, sweating occurred in attacks. Attacks were mostly triggered by warmth, exercise, emotions, or had no apparent cause. Quality of life was low in all cases. All treatments improved quality of life.
Primary Cutaneous Epithelioid Angiosarcoma
Authors: Kikuchi Aki , Satoh Takahiro , Yokozeki Hiroo
Published: April 2023

This article does not have an abstract.
Diagnosis of Hailey-Hailey Disease Facilitated by DNA Testing: A Novel Mutation in ATP2C1
Authors: Nemoto-Hasebe Ikue , Akiyama Masashi , Osawa Rinko , Nakamura Hiroyuki , Shimizu Hiroshi
Published: April 2023

This article does not have an abstract.
Nephrogenic Systemic Fibrosis with Multiple Calcification and Osseous Metaplasia
Authors: Nagai Yayoi , Hasegawa Michiko , Shinmi Kahori , Kishi Chikako , Tsushima Yoshito , Endo Keigo , Okabe Kazuhiko , Suzuki Kazuhiro , Ishikawa Osamu
Published: April 2023

We describe here a 50-year-old Japanese man with nephrogenic systemic fibrosis. He had been suffering from chronic renal insufficiency and had been treated with haemodialysis. He had undergone magnetic resonance angiography using gadodiamide 7 years previously. One month after magnetic resonance angiography, he noted swelling, hotness, induration and pain in his left arm. The same symptoms gradually spread over his lower extremities, resulting in flexion contractures with limited range of motion. Physical examination revealed skin sclerosis on his extremities with a glossy brownish skin surface. Histologically, increased collagen fibres with high cellularity were seen in the dermis and subcutaneous septa. Thickened fascia was also noted, as well as osseous metaplasia under the fascia. Computed tomography of the whole body revealed multiple calcification of the fascia in many muscles. Treatment with intravenous sodium thiosulphate did not result in any clinical improvement.
Lack of Association between Neuropeptide S Receptor 1 Gene (NPSR1) and Eczema in Five European Populations
Authors: Ekelund Elisabeth , Bradley Maria , Weidinger Stephan , Jovanovic Dragan L. , Johansson Catharina , Lindgren Cecilia M. , Todorova Antonia , Jakob Thilo , Illig Thomas , Von Mutius Erika , Braun-Fahrländer Charlotte , Doekes Gert , Riedler Josef , Scheynius Annika , Pershagen Göran , Kockum Ingrid  , Juha Kere
Published: April 2023

Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found be tween eczema and the seven single nucleotide polymor phisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.
Epithelioid Sarcoma-like Haemangioendothelioma: A Case Report
Authors: Watabe Akiko , Okuyama Ryuhei , Hashimoto Akira , Hosaka Masami , Hatori Masahito , Kariya Yoshiyuki , Watanabe Mika , Hashimoto Hiroshi , Tagami Hachiro , Aiba Setsuya
Published: April 2023

This article does not have an abstract.
Dermatoscopy for Diagnosis of Creeping Hair: A Case Report and Mini-review of the Literature
Authors: Arakawa Yukiyasu , Nakai Noriaki , Hanada Keiji , Katoh Norito
Published: April 2023

Abstract is missing (Letter)
Tratamiento de aguas residuales y problemáticas ambientales del sector textil en Colombia: una revisión
Authors: Ramirez-Rodriguez Julio Cesar
Published: April 2023

La industria textil representa una figura decisiva debido a los impactos negativos que generan sus procesos productivos en materia de calidad del agua, aire, suelo y la gestión de sus residuos. En especial, existe gran preocupación sobre el recurso hídrico, por las cantidades y los tipos de químicos que emplea esta industria. Por ello, en este artículo se lleva a cabo una revisión sobre la problemática de las aguas residuales provenientes de la industria textil y los avances tecnológicos para el tratamiento de estas. Como resultado se encuentra que, as pequeñas y medianas empresas corresponden al sector de las empresas más vulnerables en términos de su capacidad para enfrentar la creciente presión social, regulatoria y de fiscalización en materia ambiental, con necesidades de bienes y servicios ambientales que se encrudecen a raíz de la informalidad de muchas empresas, a las que, por ende, no se les realiza ningún tipo de control por parte de las autoridades ambientales. Así mismo, se identificaron diferentes metodologías de tratamiento de aguas residuales textiles, que incluyen técnicas combinadas, como la electrocoagulación y electro-oxidación, procesos avanzados de oxidación (PAO), Fenton (H2O/Fe2+) o foto-Fenton (UV/H2O2/Fe2+), entre otros, que garantizan altos rendimientos en la eliminación, por ejemplo, de parámetros como la demanda química de oxígeno (DQO), la demanda bioquímica de oxígeno (DBO), y el color. Adicional a ello, se resalta el uso de nanomateriales de titania como buenos adsorbentes de metales como plomo (Pb), cadmio (Cd), cobre (Cu), zinc (Zn), y níquel (Ni) y, como alternativa de bajo costo para las pequeñas empresas, materiales de desecho y minerales como buenos adsorbentes de colorantes, que se pueden reutilizar con altas eficiencias en varios ciclos.
Glial Response to Perinatal Multi-Hit Stress: The Triggering Factor for Schizophrenia
Authors: I Patro
Published: April 2023

Schizophrenia is a neuropsychiatric disorder with heterogeneous causative agents. This mental disorder is accompanied by impaired cognitive and behavioral abilities, hallucination and negative phenotypes. Among many identified causative agents of Schizophrenia, early life stressors like perinatal protein malnourishment and immune infections are considered to be most efficient. Furthermore, due to the world wide prevalence of protein malnourishment and infections, an individual often encounters them simultaneously, giving rise to a multi-hit condition. In this study, Wistar female rats (3 months old) were broadly divided into control (fed with 20% protein diet) and LP (low protein, fed with 8% protein diet) groups. The F1 pups born to both control and LP females were subjected to single as well as combined exposure of Poly I:C (5mg/kg body weight) and LPS (0.3mg/kg body weight) at PND 3 and 9 respectively. The overall study consists of eight groups i.e., Control, Control+Poly I:C, Control+LPS, Control+Poly I:C+LPS, LP, LP+Poly I:C, LP+LPS and LP+Poly I:C+LPS (multi-hit). All these groups were studied for glial (astrocytes and microglia) changes at PND 12, 21 and 30 and cognitive and behavioral abnormalities at PND 30 respectively. From the overall result, it was seen that both astrocytes and microglia were severely affected mainly in the multihit group, with astrogliosis, astrocytic degeneration and loss of healthy microglial activity being prominent observations. Such cellular abnormalities were followed by severe hyperactivity and memory impairment at PND 30. While such changes were also seen in single-hit group, it was not severe. Such above mentioned abnormalities are also common in Schizophrenia and multi-hit stress was observed to trigger them the most. Thus, this study adds on to Schizophrenic research and concludes that multi-hit stress is the actual triggering factor that leads to development of Schizophrenia in affected individual.
Current approaches to modeling of epidemic process of non-polio Enterovirus infections
Authors: Novoselova M. V. , Potseluev N. Yu. , Brusina E. B.
Published: April 2023

Aim. To study mathematical models for predicting the incidence of non-polio enterovirus infections (NPEVI) in the Kemerovo Region.Materials and Methods. Here we conducted a retrospective epidemiological study of NPEVI incidence in the Kemerovo region from 2006 to 2021 (n = 2152 cases). Epidemic process was studied using autocorrelation analysis, Fourier analysis, and neural networks using STATISTICA Automated Neural Networks (SANN) tool and StatTech v. 3.0.5.Results. The incidence rates of NPEVI were 9,39 per 100,000 population (2009), 15,78 per 100,000 population (2015) and 8,41 per 100,000 population (2019), exceeding the average median value (2006- 2021) by a factor of 2.4, 4.1, and 2.2, respectively. NPEVI incidence was largely determined by enteroviral meningitis. The majority of cases (89.94%) were registered in children. Notably, standard mathematical models failed to provide an objective analysis of the incidence trend. Autocorrelation analysis found the summer-autumn seasonality (August-October) by evaluating the ratio of actual data to 12-month rolling averages. Modeling of the epidemic process of NPEVI using neural networks highly likely predicted its incidence up to 52 months.Conclusion. The epidemic process of NPEVI in Kemerovo region has been characterized by a low intensity and summer-autumn seasonality. Neural networks are suggested as a promising tool to forecast the incidence of NPEVI.
Molecular genetic surveillance based on the identification of borrelia in ixodid ticks
Authors: Rudakova S. A. , Teslova O. E. , Mutalinova N. E. , Kuzmenko Yu. F. , Strek S. V. , Penyevskaya N. A. , Rudakov N. V.
Published: April 2023

Aim. To improve emergency diagnostic measures and preventive antimicrobial therapy in patients with ixodid tick bites using molecular genetic techniques for identification of Вorrelia spp.Materials and Methods. Borrelia strains were isolated by inoculation of tick suspension on the BSK-H medium. Molecular genetic screening of Вorrelia spp. was performed by real-time polymerase chain reaction (PCR) and sequencing. In total, we examined 4,276 patients including 272 bitten by Ixodes persulcatus and 3,108 bitten by Dermacentor reticulatus. In addition, we investigated blood of 896 patients for molecular signatures of Borrelia spp.Results. Borrelia spp. was detected by PCR in 30.1% of Ixodes persulcatus and 3.2% of Dermacentor reticulatus suspensions. However, detection of Borrelia spp. in blood was rare, reaching only 1.1% in those bitten by Ixodes persulcatus and two cases of Dermacentor reticulatus bites. Genotyping of Borrelia spp. in 8 tick suspensions showed the presence of Borrelia garinii in 1 sample, Borrelia afzelii in 5 samples, Borrelia bavariensis in 1 sample, and Borrelia miyamotoi in 1 sample.Conclusion. Molecular genetic screening showed the significant proportion of Ixodid ticks bearing Borrelia spp., indicating the need in specific antimicrobial therapy.
Impact of negative emotions on financial behavior: An assessment through general strain theory
Authors: Khan Khurram Ajaz , Metzker Zdenko , Streimikis Justas , Amoah John
Published: April 2023

Research background: The research has two objectives and employs a serial mediation approach. First, using the general strain theory, it examines the mediating role of negative feelings and impact of economic adversity on people's risk tolerance and prudent financial behavior. The second is determining the various categories' variations according to age.
Purpose of the article: The study's main objective is to evaluate financial behaviour of people with lower and medium incomes after the second wave of COVID-19 in India, and to contribute to the body of knowledge on general strain theory.
Methods: The study examined the proposed framework and tested the serial mediation model based on the general strain theory used as a survey method for data collection, targeting lower and middle-income individuals in India's most populated state. The study applied PLS-SEM to test the framed hypotheses. Furthermore, the Kruskal Wallis test was applied to identify the difference in the various groups classified based on age.
Findings & value added: The results reveal that economic hardship significantly influences improved financial behavior. Risk aversion attitude, loneliness, and depression mediate the relationship between economic hardship and financial behavior. Moreover, the study found quite a few significant differences between the different age groups. The present study will add to the existing literature on financial behavior under the scope of general strain theory and probably be among the few that test general strain theory with financial variables impact on lower and middle-income group individuals from a developing nation in post-COVID-19 period.
An Overview of Informed Consent in Dentistry in Malaysia
Authors: Yaakob Haniwarda
Published: April 2023

Introduction: Obtaining informed consent from patients is a fundamental legal and ethical element that is required of dental practitioners. From routine procedures such as dental filling or scaling to more complicated procedures such as oral surgeries, it is imperative that patients’ informed consent be acquired. Failure to procure a valid consent from patients prior to embarking on any dental treatment may cause several potential legal repercussions against dental practitioners. This paper, thus, seeks to discuss the issue of informed consent with particular reference to dental practice. It begins with an explanation on the laws governing informed consent in Malaysia. Then, an analysis on the ethical aspect behind the need to obtain patient’s consent, namely patient autonomy is provided. This is followed with a discussion on the potential legal consequences for failure to obtain informed consent, limiting to civil actions only. Methods: This is a descriptive paper that adopts legal doctrinal and qualitative method of analysis. Conclusion: The precondition of obtaining patients’ informed consent is a fundamental aspect in dental practice both for patients and dental practitioners.
The Effect of Mobile Health (mHealth) Interventions on Clinical Outcomes and Self-Management Behaviours in Individuals with Metabolic Syndrome: A Narrative Review of Evidence
Authors: Daud Maryam Hannah , Yusoff Fakhrul Hazman , Ramli Anis Safura
Published: April 2023

Introduction: There has been an exponential growth in mobile health (mHealth) technology for self-management of chronic conditions including metabolic syndrome (MetS). This narrative review aims to summarise the evidence on the effect of mHealth interventions on clinical outcomes and/or self-management behaviours among individuals with MetS or its components. Methods: Literature search for original research articles on mHealth for self-management of MetS or any of its components (type 2 diabetes mellitus, hypertension, dyslipidaemia, and obesity) from 2010-2021 was conducted using Web of Science, Scopus, PubMed, Cochrane Central Register of Controlled Trials, Google Scholar, SAGE and ScienceDirect. Keywords such as mHealth, effectiveness, self-management, MetS, hypertension, type 2 diabetes mellitus, dyslipidaemia and obesity were used. Articles in languages other than English, without access to full-text, outcomes unrelated to the effectiveness, and involved individuals aged <18 or >80 years old were excluded. All study designs were included except for study protocols. Results: A total of 184 potential papers were retrieved. Of these, 137 were excluded as they did not meet the inclusion/exclusion criteria. Consequently, 47 papers were included. Of these, 38 studies demonstrated effect of mHealth interventions in improving clinical outcomes (blood pressure, glycated haemoglobin, lipid profile, weight) and/or improvement in self-management behaviours (home blood pressure or blood sugar monitoring, exercise, diet or medication adherence) among individuals with MetS or its components. Only 12 studies were conducted in primary care. Apart from mHealth technologies, multifaceted elements such as doctor-patient interaction and wearable devices were also shown to be effective. Conclusion: This narrative review suggests that mHealth interventions may have positive effect on clinical outcomes and/or self-management behaviours among individuals with MetS and its components. This evidence should support development and evaluation of mHealth interventions to suit the needs of the Malaysian population, especially in primary care.
A Boy with Limping Pain: A Diagnosis Not To Be Missed
Authors: Hassan Radhiana , Jamani Nurjasmine Aida , Abd Razak Ardilla Hanim
Published: April 2023

Post traumatic limp in children and adolescent is one of the common reasons seen in primary care. However, making the correct diagnosis is not always easy for primary care physicians. This is because the signs are not specific and the radiological image may appear very subtle to the untrained eyes. Most of the time the causes are not serious and involves soft tissue injury, but at times an important condition could be missed in an inexperienced physician. This paper presents the case of a 16-year-old boy with Slipped Capital Femoral Epiphysis (SCFE) which was overlooked. This case highlights the importance of recognizing the signs of SCFE to allow for early referrals for proper management and prevent its possible complications.
Favorable Conditions for the Release of Avalanches in the 2021- 2022 Winter Season – Case Study
Authors:   Regional Meteorological Center Transilvania Sud, 49 Someșului Str, Sibiu, Romania, RECKERTH Udo , MILIAN Narcisa ,   Regional Meteorological Center Transilvania Sud, 49 Someșului Str, Sibiu, Romania
Published: April 2023

The paper presents and analyzes the synoptic and snow-meteorological conditions that were the basis for the triggering of avalanches in the winter season 2021-2022 from the mountain massifs monitored within the snow program. Data recorded at mountain weather stations with nivometric measurements were used, as well as ground and altitude maps from the GFS archive for the analysis of synoptic situations. The purpose of the presentation is to emphasize the importance of observations and nivometric measurements, as spatial and temporal density, for estimating the avalanche risk at the level of all mountain massifs. The study is part of a larger project, which aims to inventory the cases of avalanches known so far in our country and the favorable conditions for their triggering, to use them for a better estimation of the avalanche risk and the reduction of their effects have these on the environment and people. The meeting of favorable conditions for the triggering of avalanches was due both to heavy snowfalls, high thermal values or their sudden increase, as well as to the transformations that take place inside the snow layer, as a result of which unstable structures are formed.