bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPROVING EFFICIENCY IN PRE-ECLAMPSIA DIAGNOSIS: SPOT URINARY PROTEIN/CREATININE RATIO
Authors: SINGH PRAVEEN , ARNOTE POOJA , THAKUR KAJAL
Published: January 2024

Objective: Because pre-eclampsia can cause difficulties, it presents a serious threat to maternal healthcare. The well-being of both the mother and the fetus depends on a prompt and precise diagnosis. There are drawbacks to using conventional techniques, such as collecting urine for a whole day to determine proteinuria. Although the spot urine protein/creatinine ratio is a faster option, its clinical value is yet unknown.

Methods: The purpose of this cross-sectional study, which ran from July 1, 2018, to June 30, 2019, was to evaluate the spot urine protein/creatinine ratio in preeclamptic pregnant women vs the traditional 24 h urine protein collection technique. Ninety inpatients in all who satisfied certain inclusion and exclusion criteria were included.

Results: Compared to comparable research by Hanumant et al. (13%), 6.66% of patients in our study had abnormal fundus examination findings. Papilloedema was absent from all participants, and the cautious management of anomalies was consistent across investigations. In line with the results of Hossain et al. and Sapna et al., the mean urine protein creatinine ratio in our investigation was 1.75±2.32. A smaller ratio was discovered by Umran et al., whereas Jung Hwa Park et al. claimed a larger ratio. Jung Hwa Park et al. also showed a greater mean protein excretion during a 24 h period (2713±2003 mg/d).

Conclusion: This research at Kamla Nehru Hospital emphasizes the spot urine protein/creatinine ratio's potential as an effective pre-eclampsia diagnostic tool. In healthcare settings with limited resources, prompt detection of severe proteinuria can improve maternal and fetal outcomes by streamlining patient treatment.
REVOLUTIONIZING PHARMACEUTICALS: A DEEP DIVE INTO SELF NANO EMULSIFYING DRUG DELIVERY SYSTEMS
Authors: NIKAM PRAJWAL , JAIN APARNA , SOLANKI DIPTI , AHER SHUBHANGI
Published: January 2024

From nearly a decade’s time, there has been an increased inclination with respect to nanoemulsions owing to their augmented and ameliorated characteristics in comparison to conventional methods of drug delivery. Self-nano-emulsifying drug delivery systems (SNEDDS) have substantiated their effectiveness in enhancing the solubility and bioavailability of poorly soluble substances. These systems, often isotropic mixtures, consist of oils, surfactants, and cosurfactants/cosolvents. They possess the capability to create nanoemulsions or fine oil-in-water (o/w) emulsions with mild stirring and dilution by the water phase along the gastrointestinal tract. This system has proven its worth in enhancing the absorption of lipophilic agents constrained by dissolution rate. SNEDDS are extremely efficacious in improving the oral bioavailability of lipophilic products and is quite promising for managing drugs unapt for oral delivery. Additionally, it's noteworthy that SNEDDS can be formulated into various solid dosage forms suitable for both oral and parenteral administration. This overview incorporates the advancements of SNEDDS' the mechanism involved in its spontaneous formation, its subcategories, composition, approaches employed for formulation, characterization, merits and limitations, and future potential. The review also lays stress on the progress in solid self-emulsifying delivery mechanisms and dosage forms.
A SYSTEMATIC REVIEW ON NANO DRUG DELIVERY SYSTEM: SOLID LIPID NANOPARTICLES (SLN)
Authors: PHALAK SWAPNIL D. , BODKE VISHAL , YADAV REENU , PANDAV SATISH , RANAWARE MALOJI
Published: January 2024

Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tiny materials are used as diagnostic tools or to deliver therapeutic drugs to specific targeted locations in a controlled manner. Nanotechnology has numerous advantages in the treatment of chronic human diseases through the site-specific and target-oriented delivery of precise medications. There have recently been several notable applications of nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents, and so on) in the treatment of various disorders. Efficient use of pricey medications and excipients, as well as cost savings in manufacturing Beneficial to patients, improved therapy, comfort, and the standard of living. Lipids have been proposed as an alternate carrier to circumvent the constraints of polymeric nanoparticles, notably for lipophilic medicines. Such small particles of lipid are known as solid lipid nanoparticles (SLNs), and they are gaining popularity among formulators all over the world. SLNs are colloidal carriers that were developed in the last decade as a replacement for traditional carriers. Lipid nanoparticles have caught the interest of researchers during the last two decades and have shown considerable therapeutic success since the first clinical approval of Doxil in 1995. Simultaneously, lipid nanoparticles have shown significant promise in conveying nucleic acid medications, as proven by the approval of two RNA treatments and an mRNA COVID-19 vaccination.
A STUDY TO ASSESS THE ATTITUDE OF MEDICAL STUDENTS TOWARDS LEARNING COMMUNICATION SKILLS IN A TEACHING HOSPITAL IN ANDHRA PRADESH
Authors: LATHA R. ASHA , FARHANA M. A. , SONIA S. SHARON , RIYAZ N. M. , MALLIKA B. S. B
Published: January 2024

Objective: Communication plays an essential role in present era of medical and health system where doctor should maintain good interpersonal relationship with patients. Teaching of communication skills to medical students as a part of the curriculum has gained importance in recent past. This study was conducted to assess attitude of medical students towards learning communication skills.

Methods: Prior institutional ethical committee approval and prior informed consent obtained from participants. Study conducted among medical students of second and third year MBBS. Students were given a questionnaire (google forms). Questionnaire consisted of 26 items related to positive and negative attitude; 13 items in each subscale. Responses received were entered and analysed in Microsoft excel.

Results: Total of 300 students participated, with a response rate of 76%. 132(57.9%) students were second year and 96(42.1%) were third year. 159(69.7%) students were females and 69(30.3%) were males. Reliability of scale was calculated using Cronbach’s Alpha, 0.859 for PAS and 0.704 for NAS; which were good and acceptable values. Better positive attitude scores (52.34±6.03) observed over negative attitude scores (40.07±6.40), implies students having a positive attitude towards learning communication skills. There were no significant differences between scores when compared between males and females and between second and third year MBBS students.

Conclusion: Results of study emphasize that introduction of AETCOM learning modules in the medical curriculum has a positive impact on students towards learning communication skills. Doctor-patient inter-relationship, treatment decision-making, etc., are dependent on doctor’s communication skills; which can be improved and strengthened with AETCOM implementation in medical curriculum.
The Effects of Using “Elsa Speak app” on the Enhancement of College Students’ English-Speaking Skills
Authors: Nguyen Dong Thi Thao , Tuyen Le Van
Published: January 2024

Mobile-Assisted Language Learning (MALL) revolutionizes education by utilizing mobile devices to extend learning beyond traditional settings. This study aims to explore the effects of the ELSA Speak app on English-speaking skills and students’ attitudes towards the use of the app at a college in Ho Chi Minh City, Vietnam. The research involved fifty English students divided into control and experimental groups. It employed pretest and posttest, and a questionnaire for quantitative data collection. Both descriptive and inferential statistics methods were used for data analysis. The results indicated that ELSA Speak effectively enhanced students’ English speaking skills; it was also revealed that students had positive attitudes towards the use of the app. The study provided recommendations for both teachers and learners in utilizing mobile applications, specifically ELSA Speak to improve English speaking skills in the Vietnamese context.
La teoría de las inteligencias múltiples en la enseñanza de ELE
Authors: Arroyo Martínez Laura , Chavarría Pérez Cristina
Published: January 2024

Durante los últimos años, el avance de los estudios lingüísticos ha producido nuevas aplicaciones en la enseñanza de lenguas extranjeras, en particular del ELE/L2. Los avances de la lingüística cognitiva se asocian a otros logros conquistados en disciplinas como la psicología de la educación, la psicolingüística o la neurociencia. Tomando en cuenta dichos avances, los dos objetivos teóricos básicos de este trabajo son establecer: a) qué aportaciones de la teoría de las inteligencias múltiples (TIM) (teoría esencial para entender las bases del aprendizaje desde un enfoque psicológico y motivacional) han repercutido en la enseñanza del ELE; y b) qué otras interpretaciones de esta teoría pueden influir en el futuro en la enseñanza del ELE.
Asimismo, se presentará una propuesta de aplicación de las aportaciones de la lingüística y de la TIM para enseñar eficazmente unidades fraseológicas en el aula de ele. Estas unidades léxicas complejas, que son de muy diverso tipo,[1] presentan una dificultad específica para quienes aprenden ele debido a la complejidad para que pueda comprenderse su significado y para lograr un uso pragmático satisfactorio de estas. Por dicha razón es necesario avanzar en metodologías y técnicas didácticas novedosas que faciliten su aprendizaje.  
[1] La clasificación más completa de estas unidades se encuentra en García-Page (2008). Dentro de este amplio grupo de unidades fraseológicas se encuentran paremias como Hombre precavido vale por dos, fórmulas rutinarias como ¡Que vivan los novios!, frases hechas tipo A cuerpo de rey, etcétera.
El arte muralista en el desarrollo de la conciencia crítica cultural
Authors: Fuentes Rocío , Emery Alice
Published: January 2024

Los hablantes de herencia del español tienen necesidades pedagógicas especiales debido a sus habilidades lingüísticas e interculturales; sin embargo, es difícil encontrar materiales adecuados para satisfacer sus necesidades educativas dentro del salón de clases. En este trabajo, nos basamos en un marco de alfabetizaciones múltiples según el modelo de Learning by Design (Kalantzis y Cope, 2012; Cope and Kalantzis, 2015) para presentar una propuesta didáctica que tiene como objetivo explorar la identidad de los alumnos. Para ello, se toma el arte muralista como base del ensamble multimodal (Serafini, 2014). Debido a su estatus como arte público, los murales son parte de los contextos sociales, políticos y culturales en los cuales se encuentran y hacen referencia a estos, por lo que constituyen excelentes vehículos para explorar temas como la historia, las luchas sociales y la identidad de los alumnos, entre otros. Los murales también ofrecen un lenguaje visual rico en símbolos y formas de representación, lo que facilita la discusión y creación de nuevos significados y modos de comunicación. Aunque la propuesta se diseñó originalmente para alumnos hablantes de herencia de español, es lo suficientemente flexible para adaptarse a clases de lenguas extranjeras de niveles medio y avanzados.
Endocannabinoid system and eating behavior / Sistema endocannabinoide y conducta alimentaria
Authors: Ramírez-Emiliano Joel , Ortega-Barrón Iraís Guadalupe , Caudillo-Ortega Norma Angélica , Negrete-Díaz José Vicente , Pérez-Vázquez Victoriano
Published: January 2024

The objective of this systematic review was to investigate previously published literature that examined the effect of hypercaloric diet on the endocannabinoid system, eating behavior, and the development of obesity. In the present review, we analyzed and described the evidence that suggests that the regulation of the endocannabinoid system through the activation of the receptors for cannabinoid type 1 (CB1R) and type 2 (CB2R) by modulating the production of anandamide, 2-arachidonoylglycerol (2-AG) and oleamide, influence the appetite and satiety centers, inducing or inhibiting the consumption of hypercaloric foods such as Western diet; thereby altering the production of hormones like the ghrelin, insulin, peptide YY and leptin. However, the adequate doses of pure cannabinoids and/or the cannabinoid-enriched Cannabis herbal extracts for the treatment of eating disorders like anorexia and/or obesity, neither for disorders of the mood, have not determined.
Daily and risky eating behaviors in Chilean adults/Conductas alimentarias cotidianas y de riesgo en adultos Chilenos
Authors: Hun Nelson , Urzúa Alfonso , Garrido Lindsay , Santos Jessica , Leiva-Gutiérrez José
Published: January 2024

Eating behaviors can be classified as daily (CAC) and risky (CAR), and may vary in frequency and intensity. The objective was to compare daily and risky eating behaviors among men and women living in northern and central Chile. Data were collected from 916 participants, 60% were women and 40% were men, mean age of 35.2 years. The subscale of daily and risky eating behaviors of the structured interview E-TONA was used, and the response format of the items was dichotomous. Pearson's chi-square and OR tests were performed to observe whether sex represented a risk factor for developing CAC. The CAC showed that women tend mostly to eat while watching TV (56.7%), while men tend to repeat the dish and fill it (23.1%). The CARs show that women are twice as likely to eat to calm anxiety (40.7%) and men are more likely to get angry when they react or restrict their food (12.4%). Although it is possible to evidence CAR in both men and women, trends by sex and higher total frequency in men were reported. Determining types of CAC and CAR by sex can facilitate the development of targeted dietary and nutritional interventions
Una propuesta para la enseñanza y el aprendizaje en prácticas clínicas de estudiantes de fisioterapia
Authors: Chávez-Ciau Irving David , López-Gamboa Galo Emanuel
Published: January 2024

Introducción: El grado de fisioterapia se obtiene al cursar una preparación universitaria de 4 a 5 años con contenido teórico y práctico en su diseño curricular. En el segundo año de formación se realiza un periodo llamado “práctica clínica” donde, a través de la interacción con el paciente, el estudiante aprende y demuestra distintas habilidades clínicas; sin embargo, la enseñanza durante esta etapa puede descuidar competencias adicionales a la formación del alumno.

Objetivo: Diseñar una propuesta didáctica de enseñanza y aprendizaje para educadores clínicos mediante el diagnóstico de habilidades clínicas y humanas de formación identificadas en estudiantes de fisioterapia.

Método: Se realizó un estudio exploratorio y un muestreo no probabilístico por conveniencia a 2 grupos; el primer grupo formado por 32 estudiantes de la licenciatura en fisioterapia, superiores al sexto semestre, que realizaron prácticas clínicas en el área de terapia física del Hospital Regional ISSSTE “Elvia Carrillo Puerto”, durante el periodo comprendido de febrero 2019 a enero 2020; y el segundo grupo formado por 3 terapeutas adscritos de la institución, encargados de la formación clínica de los alumnos.

Resultados: De los 3 terapeutas adscritos al hospital, 1 refirió como “muy bueno” al proceso de enseñanza y aprendizaje durante las prácticas clínicas en fisioterapia; sin embargo, únicamente el 33.3% de los encuestados los aplica regularmente para la enseñanza y conclusión de habilidades en los estudiantes. El 43.8% de los alumnos encuestados categorizaron su enseñanza clínica como “bueno” durante su periodo de prácticas, siendo las habilidades clínicas las más frecuentemente practicadas y las habilidades intrapersonales las menos abordada para su aprendizaje.

Conclusiones: La propuesta de formación facilita la conclusión de mejores estándares de competencia en la formación de estudiantes en fisioterapia lo que garantiza a egresados capaces de afrontar las demandas de los pacientes, proporcionando un trato profesional y humano a sus futuros usuarios.
La justicia climática: entre la tutela y la fiscalización de las responsabilidades
Authors: Borras Pentinat Susana
Published: January 2024

El aumento del nivel de emisiones de gases de efectos invernadero intensifica el cambio climático y sus consecuencias, especialmente, en países que han contribuido escasamente al cambio climático, pero que son muy vulnerables a sus efectos. Las víctimas, que representan la mayor parte de población mundial con pocos recursos sufren las consecuencias de un modelo de desarrollo irracional y altamente contaminante preponderante en los países industrializados. Las responsabilidades climáticas son comunes, pero diferenciadas: todos los países han contribuido a generar el problema, pero en diferente medida, tanto el nivel de emisiones de gases de efecto invernadero, como las consecuencias del cambio climático difieren de un país a otro, en función de las capacidades económicas, tecnológicas y de resiliencia.
Marruecos frente a la (des)colonización del Sáhara Occidental
Authors: Riquelme Cortado Rosa
Published: January 2024

El conflicto del Sáhara Occidental es una cuestión de descolonización que ha de resolverse sobre la base de que la población (autóctona) del Territorio ejerza su derecho de libre determinación mediante consulta popular libre y responsable bajo supervisión de Naciones Unidas, siendo al menos una de las opciones la independencia. Es esta una elemental afirmación que no debería ser objeto de discusión. Sin embargo, en el Sáhara Occidental las Naciones Unidas han cedido a las maniobras dilatorias de Marruecos a fin de asegurarse una consulta popular que satisfaga sus propósitos anexionistas mediante la transformación del derecho de libre determinación del pueblo saharaui en el sí o sí de un estatuto de autonomía de la Región del Sáhara en el marco de la soberanía del Reino de Marruecos y su unidad nacional, posición inamovible para la que cuenta con importantes cómplices, dentro y fuera del Consejo de Seguridad.
Un llamado para repensar las fuentes de derecho Internacional: soft law y la otra cara de la moneda
Authors: Cárdenas Castañeda Fabián Augusto
Published: January 2024

El presente artículo cuestiona la concepción tradicional del estudio de las fuentes del derecho internacional haciendo un contraste con una de las nociones que viene presentando claros desafíos a la producción normativa internacional: el soft law o derecho suave. Para tal fin, el artículo hace una exposición general del concepto de soft law así como de sus principales características y efectos legales reales. Finalmente, se hace una formulación de cuestionamientos cuya finalidad principal es hacer un llamado respecto de la necesidad de volver a la investigación de las fuentes de derecho internacional las cuales, se considera, no deben permanecer estáticas pero deben desarrollarse en la medida en la que se dinamizan las relaciones internacionales contemporáneas.
El uso de mandatarios en los derechos de garantías mobiliarias hongkonés e inglés
Authors: Iturralde González Raúl
Published: January 2024

México ha modificado su derecho con respecto a las garantías mobiliarias en las últimas décadas. Estas modificaciones se han basado, sobre todo, en el derecho norteamericano del artículo 9o. del Código Comercial Uniforme. Sin embargo, existen otras formas de lidiar con estos asuntos dentro del mismo sistema del commonlaw. El sistema hongkonés (que está basado en el sistema inglés) no ha adoptado un sistema uni-forme como el del mencionado artículo 9o., por lo que contiene variadas formas de garantía. Asimismo, en el derecho hongkonés existe la posibilidad de nombrar un mandata-rio, quien tomará posesión del bien, para la ejecución de la garantía y vigilar el pago de la deuda.
Formación y perfección del contrato electrónico en España
Authors: Sosa Olán Henrry
Published: January 2024

En el presente trabajo estudiaremos el momento en que se perfecciona el contrato electrónico, ya que, con la entrada en vigor de la Ley de Servicios de la Sociedad de la Información y el Comercio Electrónico, volvió a revivir la polémica entre contratación entre presentes y contratación entre ausentes. Para resolver la problemática comentada, se reformaron los artículos 1.261.1 del Código Civil y 54 del Código de Comercio, unificando y adoptándose la teoría de la recepción matizada por la teoría del conocimiento. Estas reglas juegan un papel importante a la hora de que el consumidor contrate por medio de canales de comunicación, tales como el correo electrónico o también mediante una página web, pues, dependiendo de uno u otro, estaremos ante contratos de formación instantánea o contratos de formación sucesiva.
Análisis de la discrecionalidad del registrador mercantil en la inscripción de sociedades mercantiles en Venezuela
Authors: De la Rosa Iriarte Ericlis Yohana , Méndez Segovia Joseany Yetzebel , Amarís López Néstor Enrique , Muñoz Ruiz Jorge Armando
Published: January 2024

La investigación que se explica a continuación tuvo como objetivo general el análisis dela discrecionalidad del registrador mercantil en la inscripción de sociedades mercantilesen Venezuela., fundamentada en las opiniones de reconocidos autores estudiosos deltema como lo son: Crecia (2012), Chávez (2012 y Ossorio (1963), así como algunospostulados jurídicos establecidos en la Constitución de la República Bolivariana de Venezuela (1999), el Código de Comercio (1955) y la Ley del Registro Público y del Notariado (2014). La investigación se considera de tipo descriptiva con una fase documental, utilizando como técnica de recolección de datos la observación documental directa y la aplicación de un instrumento de recolección de datos, cuya validez se obtuvo a través del Comité Académico de la Facultad de Ciencias Jurídicas y Políticas de la Universidad Rafael Belloso Chacín (Venezuela). Los resultados de la investigación demuestran que la libertad de empresa representa un derecho económico establecido en nuestra constitución y el cual debe ser protegido por el Estado, como ente garante de los derechos subjetivos establecidos en el orden jurídico venezolano, del desarrollo pleno del ser humano, así como de la libertad, la justicia social y la igualdad, siendo los poderes públicos quienes establezcan las condiciones para que estos principios sean reales y se desarrollen de manera efectiva, removiendo cualquier obstáculo que dificulte su plenitud y de esa manera, promover y facilitar la participación de los individuos en la vida política,cultural, económica y social.
Competencias profesionales para la potenciación del marketing personal global en profesionales independientes
Authors: Villasmil Manzanero Paola Carolina , Hernández Corona Janeth Carolina
Published: January 2024

Esta investigación tuvo como propósito identificar las competencias profesionales para la potenciación del marketing personal global en profesionales independientes, basándose en los aportes teóricos de Musicco (2018), Guerrero (2005), Alamillo (2002), entre otros. La metodología fue explicativa, complementaria no experimental, transversal y de campo. Para recolectar los datos se utilizó un cuestionario con 2 ítems, con preguntas de selección múltiple, Este instrumento se aplicó a una muestra 69 profesionales independientes con presencia en mercados internacionales; así como una entrevista semiestructurada de 1 pregunta la cual se aplicó a 3 asesores en construcción de marcas personales internacionales. Los resultados fueron tabulados a través de una matriz de múltiples entradas y su tratamiento estadístico fue descriptivo complementario, Se ha demostrado que las habilidades blandas son fundamentales para el desarrollo de habilidades técnicas en profesionales independientes que ofrecen servicios de gestión en el mercado internacional. Esto se debe a la importancia de competencias como la comunicación, la disciplina, la organización, el liderazgo y la autogestión en sus actividades comerciales.
Bienestar laboral en la fuerza de ventas y su determinación en la competitividad de los cola-boradores en una comercializadora de soluciones industriales
Authors: Gutiérrez Yepes Agustín Rodolfo , Veloza Gutiérrez Kerlly Dayana , Villa Londoño Marlyn Dahana
Published: January 2024

Siempre trata a tus empleados exactamente de la manera cómo quieres que traten a tus mejores clientes Covey (1989). Consecuente con este planteamiento, se desarrolla el presente ejercicio investigativo, cuyo objetivo fue evaluar el impacto del bienestar laboral de la fuerza de ventas en la competitividad de los colaboradores en una comercializadora de soluciones industriales; para ello se establecen como objetivos específicos conocer la percepción de las fuerzas de ventas respecto a su bienestar laboral, evaluar la posible relación entre el bienestar laboral y la competitividad empresarial y sugerir alternativas enfocadas a mitigar las necesidades de bienestar laboral. Con este propósito se parte del cuestionamiento ¿De qué manera el bienestar laboral de la fuerza de ventas impacta la competitividad de los colaboradores en una comercializadora de soluciones industriales? A esta pregunta se dio respuesta mediante un estudio descriptivo de los factores que impactan las variables estudiadas (bienestar laboral y competitividad); dicha revisión se realizó mediante la aplicación de un instrumento tipo encuesta para el personal del área comercial como técnica de recolección de datos. Dentro de los principales hallazgos se destacan; la fuerza de ventas posee una percepción positiva respecto al bienestar que le otorga la compañía; se resalta la importancia que tienen los estímulos y la remuneración salarial, de igual manera se evidencia que el nivel de satisfacción de los colaboradores en la organización impacta la percepción de bienestar y la competitividad.
cultura tributaria y la contribución fiscal en Colombia: una discusión teórica
Authors: Parra Luna Karen Yurley , Valencia Asprilla Marisel , Valencia Ríos Daniela Irene
Published: January 2024

La cultura tributaria es un valor social; un principio por medio del cual el contribuyente y el propio Estado comprenden y asumen las responsabilidades impositivas establecidas en la ley. Ambos sujetos de la relación jurídica tributaria deben tener plena consciencia de la importancia de su deber frente a los recaudos nacionales que a su vez serán retribuidos por medio del gasto público que, bajo el poder de la Constitución Política, son responsabilidad del Estado. Al girar la mirada en diversas doctrinas que versan sobre la cultura tributaria en Colombia, se da pie a formular las siguientes interrogantes: ¿Qué nociones poseen los contribuyentes sobre la cultura tributaria?, ¿Cuáles son los factores que orientan las acciones que realizan los contribuyentes ante la cultura tributaria en Colombia?, ¿Qué estrategias se podrían implementar para fomentar la cultura tributaria en los ciudadanos?, ¿Cuáles son las consecuencias de la falta de cultura tributaria en Colombia?. Cada una de estas preguntas ha sido clarificadas en el presente trabajo investigativo que tuvo como objetivo analizar la relación existente entre la cultura tributaria y su repercusión en la evasión fiscal en Colombia, cuyas características metodológicas son: un estudio fenomenológico; descriptivo con una fase bibliográfica; se utilizaron instrumentos de recolección de datos como la observación directa y el estudio sistemático de información; así como la triangulación y el análisis del discurso como técnicas de análisis.
Excellence in Cricket leveraging AI/ML and Automation
Authors: Budhrani Tarash
Published: January 2024

Abstract: Cricket, celebrated for its multifaceted dimensions of Bowling, Batting, and Fielding, is undergoing a transformative shift with the infusion of Artificial Intelligence (AI) and Machine Learning (ML) technologies. This paper explores the profound impact of AI/ML integration in cricket, scrutinizing its influence on strategies, player development, and training methodologies. Automation emerges as a game-changer in cricket practice as AI-driven machines simulate bowlers, aiding batsmen in adaptive training scenarios. These machines foster skill development and adaptability, revolutionizing the way players refine their capabilities.
"Advanced Materials in Refrigeration Systems: An In-depth Analysis of Novel Additives and Their Influence on Heat Transfer Efficiency and Energy Consumption"
Authors: Saha Rahish Kumar
Published: January 2024

Abstract: This study explores the cutting-edge domain of nano refrigerants, aiming to boost the cooling performance of the widely used refrigerant R-134a by integrating a precisely balanced blend of CuO and SiO2 nanoparticles. The primary motivation for this research is the imperative to transform refrigeration systems, making them more energy-efficient and environmentally sustainable. The research methodology involves systematically creating a nano refrigerant by dispersing varying concentrations of CuO and SiO2 nanoparticles in R-134a. Selected for their exceptional thermal conductivity and stability, these nanoparticles have the potential to significantly enhance the heat transfer properties of the refrigerant. Initial stages encompass rigorous assessments of thermal conductivity improvements compared to the base R-134a, laying the groundwork for practical evaluations in a heat exchanger setup. In heat exchanger experiments, crucial parameters such as heat transfer coefficient, pressure drop, and overall heat transfer rate are precisely measured, providing a comprehensive understanding of the nano refrigerant’s real-world performance. The objective is not only to enhance thermal conductivity but also to optimize the nano refrigerant for effective and efficient heat exchange, thereby elevating the cooling capacity of R-134a. Stability studies are integral, ensuring the long-term viability of the nano refrigerant. Scrutinizing compatibility with commonly used refrigeration system materials and monitoring potential degradation over extended periods are essential.
IoT Enable Grass Cutter Robot - Car
Authors: Shelke Mayur S. , Chichghare Nikhilkumar P. , Bondre Shreyash U. , Maske Ankit M. , Pounikar Bhavesh R. , Panware Sneha M.
Published: January 2024

Abstract: The IoT Enabled Grass Cutter Robo-Car project represents a transformative leap in the realm of lawn maintenance, merging cutting-edge robotics with the expansive capabilities of the Internet of Things (IoT). At its core, this project introduces a state-of-the-art Robo-Car, meticulously engineered to be remotely controlled through an Android application. The crux of the communication infrastructure is a web server, with the ESP8266 serving as the linchpin by receiving signals from the server. These signals orchestrate the nuanced operations of a L298N motor driver, steering the precise movement of 100 RPM motors, and a relay module that commands the activation of the grass cutter motor. With a vision to redefine the landscape of lawn care, this project stands as an exemplar of efficiency, convenience, and remote accessibility in the realm of smart agriculture.
Communications, media and internet concentration in France, 2019-2021
Authors: Lefevre Bruno , Bouquillion Philippe
Published: January 2024

This report focuses on approximately thirty French markets, contributing to local debates and research as part of the Global Media and Internet Concentration Project (GMICP). It explores the dynamics of diversified economic players in cultural industries (press, audiovisual, books, music), emphasizing the coexistence of 'traditional' and 'new' entrants. The study provides sector-based and global analyses, revealing a dual dynamic of diversification and concentration in the production, distribution, and broadcasting of cultural and information content. Audiovisual content broadcasting, both free and pay, demonstrates national dominance but faces challenges from foreign groups. Financialization and concentration affect media and cultural goods industries, posing risks to diversity of opinion. The dominance of North American groups in digital services, particularly in advertising, is noted, impacting traditional media revenues. Telecom operators lead the French market, with regulators monitoring concentration dynamics for potential negative impacts on diversity.
In-vivo Pharmacological Evaluation of Analgesic Activity of Ethanolic Extract of Doronicum hookeri Clarke Rhizomes in Wistar Rats
Authors: Wani Shubham , Gour Rekha , Patel Anant K.
Published: January 2024

A number of plants are used traditionally in different medical conditions by practitioners of traditional medicines but their claim is not yet evaluated scientifically in laboratory animals. Based on the ethnomedical claims made by the Unani health practitioners, the Clarke rhizomes of Doronicum Hookeri was evaluated for analgesics activity in rats to confirm its claim. The successive plant extraction was carried out using Soxhlet apparatus by employing ethanol as a solvent of the dried rhizomes of Doronicum Hookeri. The % yield of extracted compound was 28.27% w/w. The qualitative preliminary phytochemical screening revealed the presence of alkaloids, saponins, tannins, flavonoids, glycosides, phenolic content, terpenoids and volatile oils in the rhizomes of ethanolic extract of D. Hookeri. The extract was orally administered in rats at low dose and high dose (200 mg/kg, 400 mg/kg) and was evaluated using Eddy’s Hot Plate Method in rats for analgesics activity. Diclofenac sodium (50 mg/kg) and was taken as a standard drug. The maximum possible analgesia % of ethanolic extract of rhizomes of D. Hookeri were found to be highest at a dose of 400mg/kg which showed 68.95% and 80% analgesia at 45 minute and 60 minute which when compared to Diclofenac sodium showed 73.28% and 85.71% at 45 minute and 60 minutes. The analgesic efficacy of ethanolic extract of rhizomes of D. Hookeri showed significant analgesic activity (p<0.04) in dose dependent manner at different time intervals of 0, 15, 30, 45 and 60 min. This asserts ethnomedical claims of some tribes regarding the analgesic activity of this plant.

Keywords - Analgesics, eddy’s hot plate, D. Hookeri, Diclofenac sodium.
Adult Onset Still’s Disease in a Patient with Fever of Unknown Origin: A Rare Case
Authors: Kumari Silky , Das Subhankar , Kumari Sudha , Ranjan Gyan , Barik Mahaprasad , Kanta Ramya Ranjan , Nishad Somnath
Published: January 2024

Adult onset Still’s disease (AOSD) is a rare clinical entity with unknown etiology, characterized by arthritis, fever, evanescent rash, and other systemic presentations. AOSD generally does not overlap with other rheumatic diseases. AOSD is a diagnosis by exclusion, and it is one of the common causes of pyrexia of unknown origin (PUO) which can be life-threatening if mistreated. Although steroids are the first line of therapy, about 20%-30% of patients are refractory, intolerant, and or relapse during tapering or upon discontinuation of steroids. There are no clinical guidelines in treating such patients, which is challenging.

Keywords:  Still’s disease, arthritis, fever, auto-inflammatory
Experimental animal models for gastric ulcer / peptic ulcer: An overview
Authors: Satapathy Trilochan , Sen Kalpana , Sahu Shailesh , Pradhan Bharti , Gupta Ayushi , Khan Md. Altaf , Kumar Dheeraj , Satapathy Abinash , Yadav Neha
Published: January 2024

In the present study we have discussed around sixteen different animal models used worldwide for the scientific research and new drug discovery.  The main aim of the using experimental animal models in drug discovery is to establish and provide evidence for non-clinical 'proof-of-concept' for the safety, efficacy, and target of interest for specific drug molecules. Experimental preparations developed in one species for the purpose of studying phenomena occurring in another species. The use of experimental animal models serves to better understand the origins, pathology, and the overall nature of comparable diseases of humans being. Similarly, animal models perform duties for in the development of safe and effective treatments and cures of such diseases and/or associated symptoms. Experimental animal models for drug discovery and development have played a major role in the characterization of the pathophysiology of diseases and associated mechanisms of injury, drug target identification, and evaluation of novel therapeutic agents for toxicity, pharmacokinetics and pharmacodynamics activity. Through animal model researchers can perform experiments that would be impractical or ethically prohibited with humans. There are various animal models used for screening of uncountable therapeutic activities, in this review our main focus is animal models used for peptic ulcer. Peptic ulcer is one of the worldwide diseases where 10% of adults are affected by peptic ulcer once in their lifetime. The antiulcer models for drug development against gastric and duodenal ulcer studies are limited in number that has hindered the progress of targeted therapy in this field. Therefore, it is necessary to review the literature on experimental animal models that are used to screen agents with potential anti-gastric ulcer activity and describe their biochemical basis in order to facilitate their use in the development of new preventive and curative antiulcer drugs. There are many models used to induce ulcer such as pylorus ligation or it can be chemically induced by ethanol, NSAIDs (e.g. indomethacin) or many more. In this review paper, current in-vivo animal models of ulcers and the pathophysiological mechanisms underlying their induction, their drawbacks, as well as the challenges associated with their use have been discussed.
Gels Containing Poloxamer 407 and Sodium Alginate as Vehicles for Vaginal Administration
Authors: N’GUESSAN-GNAMAN Kakwokpo Clémence , TUO-KOUASSI Awa Nakognon , AKA-ANY-GRAH Sandrine , CHOUGOUO KENGNE-NKUITCHOU Rosine Désirée , ANIN Apo Laurette , LIA Arthur José , N’GUESSAN Alain , DALLY Ismael
Published: January 2024

Sodium alginate and poloxamer 407 were both studied in order to design a hydrogel-based delivery system as a platform for the formulation of vaginal medecines. Sodium alginate is a natural anionic mucoadhesive polymer while poloxamer 407 is a temperature-sensitive polymer. A commercial alginate was characterized. Then, its solutions (0.5-2 % w/w), poloxamer 407 solutions (16-21.5 % w/w) and their mixtures were prepared. Their rheological properties and the influence of vaginal simulated fluid were assessed. This commercial alginate had a mannuronate-to-guluronate ratio of 1.24, a weight-average molecular weight of 300 000 ± 2% g.mol-1, a polydispersity index of 1.8 ± 3%. Alginate solutions displayed a viscous behavior not suitable for a vaginal administration. Poloxamer solutions and their mixtures with alginate were temperature-sensitive, shear-thinning, non-thixotropic and had an elastic behavior suitable for a vaginal administration. Their resistance to dilution with vaginal fluid could prolonge vaginal residence.

Keywords: Formulation, poloxamer 407, rheology, sodium alginate, temperature–sensitive, vaginal fluid, viscoelastic properties.
Solubility enhancement of meloxicam by phospholipid complexation
Authors: Bhadange Vaibhav , Kawtikwar Pravin , Jogdand Supriya , Kawtikwar Ankita
Published: January 2024

The best solubility enhancement approach is phospholipids complexation. It has been effectively employed by a number of writers to enhance the permeability, oral bioavailability, and solubility of several medicinal substances. The meloxicam is a member of BCS Class II, and because of its poor solubility and high permeability, its clinical application may have been constrained. Therefore, it is necessary to use a method that modifies the biopharmaceutical features. In this work, meloxicam, an NSAID with demonstrated anticancer action, was combined with phospholipid to increase its solubility. Utilizing solvent evaporation, the meloxicam phospholipid complex was produced. Particle size, zeta potential, SEM analysis, in vitro drug release, and solubility were assessed for the produced complex. The results obtained in this study showed the smaller particle size in nanometer range and physical stability with desired zeta potential. Meloxicam's prolonged release from the phospholipid complex is demonstrated by the in vitro drug release investigation.  The apparent solubility analysis of meloxicam phospholipid complex. Pure meloxicam showed that the drug's solubility was several times higher than that of the pure form. Hence in conclusion we can say that the phospholipid complexation could be the ideal method for solubility enhancement of drug like meloxicam.

Keyword: Meloxicam, phospholipid complex, solubility, drug release
Por uma linguística da solidariedade
Authors: Baronas Roberto Leiser
Published: January 2024

Este artigo está dividido em três momentos. Esses momentos estão organizados entorno da mistura (ZILBERBERG, 2011) de atividades de ensino, extensão e pesquisa. No primeiro, apresentamos o Projeto de Extensão intitulado Enciclopédia Discursiva da Covid19, desenvolvido na Universidade Federal de São Carlos, - UFSCar – numa parceria entre o Departamento de Letras e o INFORMASUS da UFSCar, durante a fase mais aguda da Pandemia (2020, 2021 e parte de 2022), disponível em: https://informasus.ufscar.br/enciclopedia-discursiva-da-covid-19/. Na sequência, com bem menos vagar, descrevemos outro Projeto de Extensão a I Escola Solidária de Altos Estudos do Discurso – I ESAED, desenvolvido, no Departamento de Letras da UFSCar, disponível no Canal do Leedim, no YouTube - https://www.youtube.com/c/leedimufscar. Por último, trazemos para o centro do debate a necessidade de instauração de práticas acadêmicas solidárias, tais como as descritas nos dois projetos de extensão mencionados, como forma de resistir humanizando as instituições universitárias no pós-pandemia.
Improvement of Point Spread Function Estimation Method for Motion Blurred Image and Image Restoration
Authors: Gong Zhao-yu , Zhang Gui-cang
Published: January 2024

The estimation of point spread function (PSF) of motion-blurred images is the key to image restoration, which is mainly affected by two physical quantities: blur angle and blur length. The traditional point spread function estimation method is easy to be disturbed by the bright cross in the centre of the blurred image spectrum when estimating the fuzzy angle, which affects the quality of image restoration. In addition, when using the traditional Radon transform to detect fuzzy angles, the area of bright spots in the picture is large, which will cause large fluctuations in the detection results. Therefore, this paper proposes a cepstrum analysis method for motion blurred images. Firstly, the gradient cepstrum estimation of the blurred image is given, and the cepstrum is binarized and further refined by setting the gray threshold of the cepstrum. Finally, the line fitting is performed on the refined binary image, and the slope of the fitting line is calculated, so that the point spread function of the blurred image can be accurately and directly estimated, and better image restoration effect can be obtained.
Systematic Regional Aerosol Perturbations (SyRAP) in Asia using the intermediate-resolution global climate model FORTE2
Authors: Stjern Camilla Weum , Joshi Manoj , Wilcox Laura J. , Gollop Amee , Samset Bjørn Hallvard
Published: January 2024

Emissions of anthropogenic aerosols are rapidly changing, in amounts,
composition and geographical distribution. In East and South Asia in
particular, strong aerosol trends combined with high population
densities imply high potential vulnerability to climate change. Improved
knowledge of how near-term climate and weather influences these changes
is urgently needed, to allow for better-informed adaptation strategies.
To understand and decompose the local and remote climate impacts of
regional aerosol emission changes, we perform a set of Systematic
Regional Aerosol Perturbations (SyRAP) using the reduced-complexity
climate model FORTE 2. Absorbing and scattering aerosols are perturbed
separately, over East Asia and South Asia, to assess their distinct
influences on climate. In this paper, we first present an updated
version of FORTE2, which includes treatment of aerosol-cloud
interactions. We then document and validate the local responses over a
range of parameters, showing for instance that removing emissions of
absorbing aerosols over both East Asia and South Asia is projected to
cause a local drying, alongside a range of more widespread effects. We
find that SyRAP-FORTE2 is able to reproduce the responses to Asian
aerosol changes documented in the literature, and that it can help us
decompose regional climate impacts of aerosols from the two regions.
Finally, we show how SyRAP-FORTE2 has regionally linear responses in
temperature and precipitation and can be used as input to emulators and
tunable simple climate models, and as a ready-made tool for projecting
the local and remote effects of near-term changes in Asian aerosol
emissions.
Characterization and evolution of seismic sequences in the normal fault environment of the Southern Apennines
Authors: Uccio Francesco Scotto di , Michele Maddalena , Strumia Claudio , Supino Mariano , Beroza Gregory C. , Chiaraluce Lauro , D'Agostino Nicola , Festa Gaetano
Published: January 2024

The use of seismic catalogs enhanced through advanced detection
techniques improves the understanding of earthquake processes by
illuminating the geometry and mechanics of fault systems. In this study,
we performed accurate hypocentral locations, source parameters
estimation and stress release modelling from deep catalogs of
microseismic sequences nucleating in the complex normal fault system of
the Southern Apennines (Italy). The application of advanced location
techniques resulted in the relocation of ~ 30% of the
earthquakes in the enhanced catalogs, with relocated hypocenters clearly
identifying local patches on kilometer-scale structures that feature
consistent orientation with the main faults of the area. When mapping
the stress change on the fault plane, the inter-event distance compared
to the size of the events suggests that the dominant triggering
mechanism within the sequences is static stress transfer. The
distribution of events is not isotropic but dominantly aligned along the
dip direction. These slip-dominated lineations could be associated with
striations related to fault roughness and could map the boundary between
locked and creeping domains in Apulian platform and basement.
Simulation of water isotopes in combustion-derived vapor emissions in winter
Authors: Yang Yan , Yoshimura Kei
Published: January 2024

With urbanization, anthropogenic water vapor emissions have become a
significant component of the urban atmosphere. Fossil fuel
combustion-derived vapor (CDV) is a primary source of these emissions.
Owing to the notably low CDV d-excess, stable hydrogen and oxygen
isotopes are promising for distinguishing CDV from natural sources.
Considering the limitations of in situ observations, this study aims to
explore the feasibility of using IsoRSM, an isotopically enabled
regional atmospheric model, to simulate CDV emissions in urban areas in
winter. Two experiments were conducted: one in Salt Lake City in January
2017 and another in Beijing in January 2007. The simulation results
showed that the CDV addition significantly reduced the water vapor
d-excess, particularly when the boundary layer was stable. The
simulation with CDV emissions aligned better with the time series of in
situ observations in Salt Lake City. The modification led to a more
pronounced positive correlation between vapor d-excess and specific
humidity, which was similar to the observation of Salt Lake City. The
CDV inclusion significantly increased the vapor d-excess variability
with varying wind directions in both sites. However, in Beijing, the
underestimation of d-excess variation from natural sources caused a
bigger discrepancy between the observed and simulated d-excess and CDV
fraction. Thus, though there were still biases, the inclusion of CDV
could improve the accuracy of isotopic simulation in the urban regions
where CDV was one of the controlling factors of vapor d-excess.