bluuebunny/crossref_metadata_2025 huggingface dataset:
Conscientização sobre a LIBRAS no atendimento a pacientes surdos na unidade básica de saúde: um relato de experiência
Authors: Sousa Jhonata Willian Amaral , Silva Milena Pereira da , Lima Isabella Francilayne de Jesus , Santos Nayara Lays França dos , Reis Bruna Hipólito Moreira , Oliveira Soraia Silva Odílio de , Oliveira Paula Nicoly Maria de , Silva Gabriela Virginia Sena , Oliveira Amanda Regina Barros de , Miguel Geisyrlânia Caroliny Sousa , Menezes Morgana Luzia da Silva , Alves Jéssica Vitória dos Santos , Lemos Maria Assunção da Silva , Oliveira Isabela Virgínia Idalino de , Santos Ezequiel Moura dos , Veras Daniele Siqueira
Published: November 2020

A necessidade de comunicação é ferramenta imprescindível para o desenvolvimento sociocultural de seres humanos. A inclusão de pessoas com algum tipo de deficiência faz-se necessária e justa frente à sociedade na qual ela esteja inserida, levando em consideração suas particularidades. E, para pessoas com deficiência auditiva não seria diferente, a Língua Brasileira de Sinais tornou-se uma ferramenta preciosa e indispensável a uma comunicação efetiva entre os interlocutores envolvidos. No entanto, muitas dificuldades ainda são encontradas por essas pessoas, ainda mais no que diz respeito a um eficaz atendimento relacionado à quando se fala em saúde. Tem-se como objetivo investigar o conhecimento de Libras por profissionais da saúde e a percepção dos mesmos frente ao atendimento a pacientes surdos. Tendo como população alvo profissionais da área da saúde integrantes da UBS Leopoldo Lins, localizada no município de Tamandaré-PE. Sendo aplicado por meio de um questionário estruturado, referente ao conhecimento de libras, em um ambiente propício, os dados coletados e posteriormente esse questionário será analisado e demonstrado por meio de descrição quantitativa. Foi possível identificar uma amostra variada em relação ao perfil acadêmico e atuação profissional, na análise dos resultados dos questionários foi identificado que dos 6 profissionais entrevistados apenas 1 (16,6%) relatou ter conhecimento parcial sobre a língua. Pode-se concluir que muitos profissionais alegam não ter esse conhecimento, o que dificulta, a assistência ao paciente, que muitas vezes não é compreendido pelo profissional e os profissionais que também não conseguem atender todas as suas necessidades de forma efetiva.
SERVICES MARKETING MIX SERVICES SATISFACTION HOTEL INI LUWUK (CASE STUDY HOTEL ESTRELLA, HOTEL SANTIKA, AND SWISS BEL INN)
Authors: Yusuf Chaerul Fahmi , Mambuhu Nur Mawati
Published: November 2020

The existence of hotels in Luwuk as part of the development of tourism is expected to continue were able to make improvements in order to meet customer satisfaction. Competition is carried out for hotels is also a travel promotion for the region Banggai as part of improving the economy. The ability of the company or hotel to deserve their services for customer satisfaction with the services provided by the hotel management is essential for the realization of the purpose of moving company on the basis of this profit. The purpose of this study was to determine the marketing mix to the satisfaction of hotel services in Luwuk. The method used in this research is quantitative research methods and uses IBM SPSS Statistics 24 as a data processing tool validity, reliability, correlation and linear regression. The results showed that the marketing mix to the satisfaction of hotel services in Kota Luwuk spread evenly, where none of the hotels mastering seven aspects of customer satisfaction assessment (marketing mix)
KRI DESIGN AND MITIGATION STRATEGY ON WATER DISTRIBUTION OF PERUMDA AIR MINUM MAKASSAR REGIONAL IV: A Case Study
Authors: Herdianzah Yan
Published: November 2020

Municipal Waterworks Corporation (PERUMDA AIR MINUM) of Makassar city currently finds many common risks in water distribution process. The risks cause a lot of damage to the piping network system, so that the quantity of distributed water to customers is not optimal. Consequently, it is necessary to handle the risks. This study aims to determine the risks that occur in water distribution process by using Delphi method to identify potential risks. Then, House of Risk (HOR) is used at the risk analysis and evaluation stage to determine mitigation strategies and Key Risk Indicators (KRI) is designed to determine the Early Warning System (EWS). Based on the results known that there are 16 identified risk events and 24 risk agents. Furthermore, a mitigation strategy is carried out on the risk agent by using 18 preventive actions. Based on the selected risk, coded as A24 with the indicator value is Information (Field Team) has lower threshold of 5 hours and upper threshold of 8.19 hours. Water loss has lower threshold of 3,118,047 m3 and upper threshold of 3,283,688 m3. A1 as Expired indicator value has lower threshold of 20 years and upper threshold of 26 years and leaking pipes replacement has lower threshold of 15 years and upper threshold of 16 years 3 months 2 weeks. Further research is expected to be able to design KRI for the risks that do not have EWS yet.
First experience with MRI-guided vacuum aspirated breast biopsy
Authors: Mazo M. L. , Jacobs O. E. , Puchkova O. S. , Feldsherov M. V. , Kondratyev E. V.
Published: November 2020

The rate of detection of breast cancer by MRI, while other methods of radiological diagnosis are not sufficiently informative, ranges from 5.2 to 26.3 per cent. Suspicious breast tumors of category BI-RADS 4, 5 show morphological image-guided biopsy verification, in particular MRI with contrast. Purpose. To show the possibilities and features of carrying out MRI-guided vacuum breast biopsy, including after aesthetic breast augmentation. Material and methods. A comprehensive X-ray, ultrasound and MRI examination of 54 women aged between 28 and 70 years with different breast tumors was conducted. Of these, five were detected only by breast MRI with contrast, and were morphologically verified by MRI-guided vacuum aspiration biopsy. Results. 14 of the 54 patients with breast mass were diagnosed with breast cancer and 26 were diagnosed with benign diseases. The effectiveness of comprehensive examination and low-invasive high-tech MRI-guided procedures in early refined screening for breast cancer, including after aesthetic breast augmentation, has been demonstrated. MRI-guided vacuum-assisted breast biopsy is a fast, safe and accurate diagnostic method of morphological verification of suspicious breast tumors that do not have X-ray and ultrasound.
Tumors of appendix: modern understanding about features of clinical course, diagnosis, treatment and prognosis (literature review)
Authors: Chubakova G. V. , Polikarpova S. B. , Kozlov N. A.
Published: November 2020

The article describes the main histological types of tumors of the appendix, epidemiological, prognostic, and clinical features, as well as current recommendations for the diagnosis and treatment of these tumors.
Features of clinical course, morphological diagnosis and prognosis factors for neuroendocrine neoplasms of rare localizations
Authors: Abbasova D. V. , Polikarpova S. B. , Kozlov N. A. , Artamonova Ye. V. , Kirsanov V. Yu. , Selivanova V. V. , Kovalenko I. P.
Published: November 2020

Currently, neuroendocrine neoplasms (NENs) of the gastroenteropancreat-ic and bronchopulmonary systems are well studied and the most common, the share of which is 73 and 25 % of cases, respectively. The remaining 2 % of cases are attributed to NEN of more rare localizations, the static registration of which is difficult due to their rarity, and clinical cases are presented by episodic descriptions of single observations. Such tumors include NEN of the prostate gland from 0.5 to 1.0 %, NEN of ovaries 0.5 %, NEN of the mammary gland from 0.3 to 0.5 %, NEN of the kidney (practically devoid of static data), bladder 0.48-1.00 %. The retrospective study included 92 patients with NEN of rare localizations who were examined and treated of the N. N. Blochin National Medical Research Center of Oncology from 1990 to 2019. Currently, there are no generally accepted methods of treatment for this group of patients due to the rarity of the pathology, and it is carried out according to the NEN of other localizations. NEN of rare localizations have high survival rates (the observation period was from a month to 14 years), both general and without progression and require long-term monitoring and observation. At the time of assessment of long-term results, 20 (21.8 %) patients died of progression, 12 (13.1 %) patients dropped out of observation. The rest were alive at the date of the last control.
ESR1 mutation as potential predictive marker for choice of treatment tactics in hormone-resistant HR+/HER2-negative breast cancer
Authors: Kolyadina I. V. , Poddubnaya I. V.
Published: November 2020

The analysis of the current strategy for the treatment of advanced HR+/HER2-negative metastatic breast cancer (mBC) was carried out, the criteria for hormone sensitivity and hormone resistance were given, and the changes in the classification of tumors were reflected taking into account the level of expression of estrogen receptors. A detailed characterization of a new potential marker of acquired hormone resistance - activating somatic mutation of the estrogen receptor gene ESR1, leading to constitutive ligand-independent activity of the estrogen receptor is given; describes the predictive and prognostic role of ESR1 mutation, its association with the clinical course of the disease and response to endocrine therapy. The paper presents studies to find the optimal treatment regimen after progression to CDK4/6 inhibitors, including the emergence of ESR1 mutations. The characteristics and key advantages of eribulin chemotherapy in patients with hormone-resistant mBC are presented, and preliminary results of the EMPOWER study on the potential for eribulin use after progression to CDK4/6 inhibitors are presented. This review will help form the concept of a personalized approach to the choice of a treatment strategy for hormone-resistant mBC.
Analyzing mobile phone usage in agricultural modernization and rural development
Authors: Khan Nawab , Siddiqui Badar N. , Khan Nanak , Khan Farhatullah , Ullah Naqeeb , Ihtisham Muhammad , Ullah Rahmat , Ismail Sohaib , Muhammad Syed
Published: November 2020

The agricultural sector worldwide is facing many issues relating to crop productivity due to the lack of communication between extension workers and farmers. To reduce this gap, information technology like mobile phones are one of the essential communication devices in numerous fields as well as agriculture. This review aims to analyze mobile phone usage in agricultural modernization and rural development. The advancement of the agricultural sector in rural areas is essential for reducing poverty among growers. As we all know, agricultural activities provide employment opportunities and generate income in rural areas. Poverty can be decreased by advancement in the agriculture sector for better production. Agriculture production, socioeconomic conditions, and food security can be improved by increasing the usage of mobile phones for easy and accurate agricultural knowledge sharing to the farming community.
Efficacy of Organic Amendments and Soil Solarization against Wilt Severity and their Effects on Pathogenic Fungi and Tomato Production
Authors: Jabnoun-Khiareddine Hayfa , Mejdoub-Trabelsi Boutheina , Aydi Ben Abdallah Rania , Sedki Riad El-Mohamedy Riad , Daami-Remadi Mejda
Published: November 2020

Soil solarization coupled or not with three soil amendments (cattle manure, bio-compost, and Biocat-15) was evaluated for its efficacy against vascular wilt severity on tomato plants grown under greenhouse conditions in a naturally infested soil. In solarized plots, wilt severity, estimated through the vascular discoloration extent and noted on randomly selected tomato plants, was significantly reduced following all the tested organic amendments. Complete wilt suppression was achieved using cattle manure. Vascular wilt severity noted on symptomatic tomato plants was 28% higher in non-solarized plots than in solarized ones and this for all organic amendments combined. Plots amended with Biocat-15 showed 29% less disease severity as compared to the two other treatments. Fungal isolations performed on Potato Dextrose Agar medium from roots, collars and stems of symptomatic and randomly selected plants, revealed the involvement of Fusarium oxysporum, F. solani, Rhizoctonia solani, Colletotrichum coccodes and R. bataticola in the observed wilts. Their isolation frequencies varied depending on wilt severity, solarization treatments (solarized or non-solarized) and tested soil amendments. Tomato production varied significantly depending on solarization treatments and tested organic amendments. Plants amended with cattle manure yielded significantly comparable production in the solarized and non-solarized plots while this production parameter was reduced by 19 and 27% following Biocompost and Biocat-15 treatments, respectively, on tomato plants grown in non-solarized plots. As for solarization effects, for all organic amendments combined, tomato production was significantly reduced by about 15% in the non-solarized greenhouse compared to the solarized one. Results from the current study showed that, under natural Tunisian conditions, single application of solarization combined with organic amendment not only reduced wilt severity, but also significantly enhanced tomato production. Thus, the repetitive combination of solarization and organic amendments could be a credible alternative for managing various soilborne fungal diseases and improving tomato yield in heavily infested fields.
Effect of Single and Combined Inoculations of Potato Plants with Four Fusarium Species on Wilt Severity, Plant Growth, and Production
Authors: Mejdoud-Trabelsi Boutheina , Jabnoun-Khiareddine Hayfa , Abdallah Rania A. B. , Ammar Nawaim , Daami-Remadi Mejda
Published: November 2020

Potato (Solanum tuberosum L.) Fusarium wilt is an increasingly serious disease in many potato-growing regions worldwide and notably in Tunisia. Fusarium sambucinum, F. oxysporum, F. solani, and F. graminearum are the main causal agents with F. oxysporum being the most aggressive on plants. Co-infection with this Fusarium species complex is frequently observed. Cultivar responses to different pathogen mixtures can give additional information on the relative aggressiveness of the different complexes. This study may lead to a better understanding of how interactions between the four Fusarium species may affect disease incidence and severity. Interactions between these Fusarium species was evaluated using single and combined inoculations (15 different Fusraium inocula) onto potato the two cultivars Spunta and Oceania. The tested inocula were evaluated for their effects on leaf yellowing and necrosis, vascular discoloration severity, potato growth and production. Necrosis severity noted 75 days post-planting induced by three different inocula C2-1 (F. sambucinum + F. solani), C2-2 (F. solani + F. oxysporum), and C3-3 (F. sambuinum+F. oxysporum +F. graminearum) were found to be the highly aggressive inoculation treatments. Overall, all mixed inocula including F. sambucinum showed increased aggressiveness levels. The two cultivars exhibited differential response to the different tested Fusarium mixtures and behaved in the majority as sensitive to moderately sensitive to C1-1, C1- 4, C2-1, C2-2, C2-3, C2-4, C2-5, C2-6, C3-1, C3-3, C3-4 and C4 treatments. This study clearly demonstrated that Fusarium wilt of potato is expected to be more severe when more than one Fusarium species is present. The relative predominance of F. sambucinum may reflect its competitive potential in mixture and its significant involvement in potato Fusarium wilt severity.
Gill's mealybug, Ferrisia gilli, can Transmit Grapevine Leafroll-associated Virus-3 after a 24-hour Acquisition Time
Authors: Jones Taylor , Nita Mizuho
Published: November 2020

Grapevine leafroll disease (GLD) is a virus disease present in all grapevine-growing regions of the world. Mealybugs and scale insects have been reported as vectors of some grapevine leafroll-associated viruses belongs to the ampeloviruses (family Closteroviridae) in particular with grapevine leafroll-associated virus-1 (GLRaV-1) and GLRaV-3. Both grape (Pseudococcus maritimus) and Gill’s mealybugs are commonly present in Virginia vineyards, but we have limited information on acquisition and transmission of GLRaV-3 by Gill's mealybug (Ferrisia Gilli). We conducted acquisition and transmission assays in the greenhouse to examine the threshold for shorter acquisition time of GLRaV-3 with F. gilli. Approximately 67% and 58% rates of GLRaV-3 acquisition by F. gilli following 24 and 48 hours, respectively, of feeding period were documented. F. gilli first instars fed on a GLRaV-3-positive grapevine for 24 and 48 hours successfully transmitted GLRaV-3 to healthy grapevines after 24 hours of feeding/transmission time. The quick acquisition demonstrated in this study could be one of the factors that promoted the rapid expansion of GLRaV-3-infected vines in vineyards documented in previous studies.
Fuzûlî'nin "Terk" ile İmtihanı
Authors: GÜMÜŞ Mustafa Yunus
Published: November 2020

Hayatın en önemli unsuru olan insan, dünyaya geldiği günden itibaren farklı zamanlarda ve farklı nedenlerden dolayı durumunu, konumunu, mekânını değiştirmiştir. Elest meclisinden beri süregelen bu yer değiştirme olgusu, her zaman bireyin istemiyle gerçekleşmemiştir. Zorunluluklar, gereklilikler, bireysel ve toplumsal sorumluluklar insanı bu kaçınılmaz durumun içine çekmiştir. “Terk etmek” olarak adlandırdığımız bu durum, hayatının hemen her aşamasında insanın karşısına çıkmış ve insanı sosyal, psikolojik, ekonomik birçok yönden etkilemiştir. Sosyal hayat ile iç içe olan divan şairleri, “terk” kavramını şiirlerinde oldukça sık kullanmışlardır. Fuzûlî’nin şiirlerinde “terk” kavramının kullanımı ile ilgili bu çalışmamızda, şairin bu kavramı hangi yönlerden ele alarak kullandığını; “terk” kavramının, şairin anlam dünyasındaki yerini ortaya koymaya çalışacağız.
Ergenlerde Duygusal Öz Yeterlik ile Üç Boyutlu Bağlanma Arasındaki İlişkinin İncelenmesi
Authors: İncekara Harun İsmail
Published: November 2020

Bu çalışmanın temel amacı; ergenlerin bağlanma stilleri ve duygusal öz yeterlik düzeyleri arasındaki ilişkiyi ortaya koymaktır. Araştırmanın evreni İstanbul ili Zeytinburnu ilçe sınırları içindeki alt, orta ve üst sosyoekonomik düzeyden seçkisiz olarak belirlenen 9 liseyi kapsamakta ve 250 öğrenciden oluşmaktadır. Araştırmada ergenlerin bağlanma stillerini belirlemek amacıyla Üç Boyutlu Bağlanma Stilleri, duygusal öz yeterliklerini tespit etmek amacıyla ise Duygusal Öz Yeterlik Ölçeği kullanılmıştır. Araştırma sonucuna göre anne-babası birlikte olan ergenlerin güvenli bağlanma biçimine sahip olduğu tespit edilmiştir. Araştırma bulgularına göre ergenlerin duygularını anladığı görülmüştür. Çalışmanın bir diğer sonucu ise fiziksel ya da sözel şiddet gören ergenlerin duygularını algılamada sorun yaşadıkları görülmüştür. Anne eğitim düzeyi yüksek olan ergenlerin kaçınan bağlanma stiline sahip oldukları tespit edilmiştir. Sonuç olarak ergenlerin bağlanma stillerini etkileyen tek unsurun duygusal öz yeterlik düzeyleri olmadığı aynı zamanda anne-baba tutumu, anne-babanın sağ olup olmaması ve anne-baba eğitim düzeyi gibi faktörlerin etkili olabileceği söylenebilir.
Ions, the Movement of Water and the Apoptotic Volume Decrease
Authors: Bortner Carl D. , Cidlowski John A.
Published: November 2020

The movement of water across the cell membrane is a natural biological process that occurs during growth, cell division, and cell death. Many cells are known to regulate changes in their cell volume through inherent compensatory regulatory mechanisms. Cells can sense an increase or decrease in their cell volume, and compensate through mechanisms known as a regulatory volume increase (RVI) or decrease (RVD) response, respectively. The transport of sodium, potassium along with other ions and osmolytes allows the movement of water in and out of the cell. These compensatory volume regulatory mechanisms maintain a cell at near constant volume. A hallmark of the physiological cell death process known as apoptosis is the loss of cell volume or cell shrinkage. This loss of cell volume is in stark contrast to what occurs during the accidental cell death process known as necrosis. During necrosis, cells swell or gain water, eventually resulting in cell lysis. Thus, whether a cell gains or loses water after injury is a defining feature of the specific mode of cell death. Cell shrinkage or the loss of cell volume during apoptosis has been termed apoptotic volume decrease or AVD. Over the years, this distinguishing feature of apoptosis has been largely ignored and thought to be a passive occurrence or simply a consequence of the cell death process. However, studies on AVD have defined an underlying movement of ions that result in not only the loss of cell volume, but also the activation and execution of the apoptotic process. This review explores the role ions play in controlling not only the movement of water, but the regulation of apoptosis. We will focus on what is known about specific ion channels and transporters identified to be involved in AVD, and how the movement of ions and water change the intracellular environment leading to stages of cell shrinkage and associated apoptotic characteristics. Finally, we will discuss these concepts as they apply to different cell types such as neurons, cardiomyocytes, and corneal epithelial cells.
Prevalence and Genetic Characterization of Two Mitochondrial Gene Sequences of Strobilocercus Fasciolaris in the Livers of Brown Rats (Rattus norvegicus) in Heilongjiang Province in Northeastern China
Authors: Zhao Fengnian , Zhou Yun , Wu Yanchen , Zhou Kexin , Liu Aiqin , Yang Fengkun , Zhang Weizhe
Published: November 2020

Rodents constitute the largest and most successful group of mammals worldwide. Brown rats (Rattus norvegicus) are one of the most common rodent species, and they serve as intermediate hosts of Hydatigera taeniaeformis. Although there have been a few studies reporting on the presence of the larval form of H. taeniaeformis (strobilocercus fasciolaris) in brown rats worldwide, little information is available on the genetic characterization of this parasite, with no molecular data from China. Therefore, from April 2014 to March 2016, this study was carried out to understand the prevalence and genetic characters of strobilocercus fasciolaris in brown rats captured in Heilongjiang Province in northeastern China. The livers of brown rats were collected and examined for the presence of cysts. Each cyst was identified based on morphological observation: the larvae with the naked eye and the scolexes under a microscope. The results were confirmed by polymerase chain reaction (PCR) and sequencing of the cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 4 (nad4) genes. At the investigated sites, 11.8% (13/110) of the brown rats were infected with strobilocercus fasciolaris. Based on sequence analysis, there were 10 and six haplotypes regarding the cox1 and the nad4 loci, with 24 and 42 polymorphic sites, respectively (degree of intraspecific variation: 0.3%–4.4% and 0.6%–4.7%, respectively). Twelve nucleotide sequences (six of the 10 at the cox1 locus and all six at the nad4 locus) have not previously been described. Base differences in three of the six novel cox1 gene sequences and five of the six novel nad4 gene sequences caused amino acid changes. Phylogenetic analyses of the cox1 and nad4 gene sequences based on neighbor-joining and Bayesian inference trees indicated that all the strobilocercus fasciolaris isolates belonged to Hydatigera taeniaeformis sensu stricto (s.s.). This is the first report on the genetic characterization of strobilocercus fasciolaris in brown rats in China. The findings of novel cox1 and nad4 nucleotide and amino acid sequences may reflect the region-specific genetic characterization of the parasite. The data will be useful to explore the biological and epidemiological significance of the intraspecific variation within H. taeniaeformis s.s.
Adult Mouse Retina Explants: From ex vivo to in vivo Model of Central Nervous System Injuries
Authors: Schaeffer Julia , Delpech Céline , Albert Floriane , Belin Stephane , Nawabi Homaira
Published: November 2020

In mammals, adult neurons fail to regenerate following any insult to adult central nervous system (CNS), which leads to a permanent and irreversible loss of motor and cognitive functions. For a long time, much effort has been deployed to uncover mechanisms of axon regeneration in the CNS. Even if some cases of functional recovery have been reported, there is still a discrepancy regarding the functionality of a neuronal circuit upon lesion. Today, there is a need not only to identify new molecules implicated in adult CNS axon regeneration, but also to decipher the fine molecular mechanisms associated with regeneration failure. Here, we propose to use cultures of adult retina explants to study all molecular and cellular mechanisms that occur during CNS regeneration. We show that adult retinal explant cultures have the advantages to (i) recapitulate all the features observedin vivo, including axon regeneration induced by intrinsic factors, and (ii) be anex vivoset-up with high accessibility and many downstream applications. Thanks to several examples, we demonstrate that adult explants can be used to address many questions, such as axon guidance, growth cone formation and cytoskeleton dynamics. Using laser guided ablation of a single axon, axonal injury can be performed at a single axon level, which allows to record early and late molecular events that occur after the lesion. Our model is the ideal tool to study all molecular and cellular events that occur during CNS regeneration at a single-axon level, which is currently not doablein vivo. It is extremely valuable to address unanswered questions of neuroprotection and neuroregeneration in the context of CNS lesion and neurodegenerative diseases.
The Impact of COVID-19 Pandemic on the Castile and Leon Addiction Treatment Network: A Real-Word Experience
Authors: Roncero Carlos , Vicente-Hernández Begoña , Casado-Espada Nerea M. , Aguilar Lourdes , Gamonal-Limcaoco Sinta , Garzón María A. , Martínez-González Fernando , Llanes-Álvarez Carlos , Martínez Ruth , Franco-Martín Manuel , Álvarez-Navares Ana
Published: November 2020

Background: Patients suffering from addiction are a vulnerable group in the midst of COVID-19, so their healthcare is considered essential. In this paper, the measures and responses of the Drug Addiction Assistance Network of Castile and Leon (DAACYL) in Spain during the first 6 weeks of the COVID-19 pandemic are explained. The aim is that this experience could be useful in places where this problem will continue and could help future interventions.

Methods: A telephone survey was carried out as the main methodology, to collect information for the subsequent organization and repercussion on professionals and patients. This was carried out by the heads of the 18 DAACYL units. Among the interventions applied, the following stand out: implantation of telemedicine techniques, restriction of daily methadone dispensing, suspension of urine controls and initiation of care programs for the homeless.

Results: As a result of these interventions, the professionals observed that patients are less demanding and mostly stable, with a low percentage of relapses. An increase in the consumption of alcohol and benzodiazepines have been reported as more common among people who relapse. Furthermore, the prevalence of COVID-19 infection in the sample is minimal; therefore, different hypotheses should be considered as an explanation (infra-diagnosis, immune system used to aggression, possible anti-inflammatory effect of some psychotropic drugs and a greater perception of danger against infection than the general population).

Conclusions: The rapid adaptation and successful implementation of DAACYL have had satisfactory results. On the other hand, the prevention of the possible increase in the development of behavioral addictions and the use of homemade drugs should be considered.
Changes in Fatigue Recovery and Muscle Damage Enzymes after Deep-Sea Water Thalassotherapy
Authors: Kim Nam-Ik , Kim Sagn-Jin , Jang Jee-Hun , Shin Woon-seob , Eum Hyok-ju , Kim Buom , Choi Ahnryul , Lee Sang-Sik
Published: November 2020

The purpose of this study was to verify the effect of deep-sea water thalassotherapy (DSWTT) on recovery from fatigue and muscle damage. The same exercise program is conducted in general underwater and deep-sea water to confirm the characteristics of deep-sea water through fatigue recovery and muscle damage enzymes. A total of 30 male college students were studied, including 10 belonging to the control group (CG), 10 in the water exercise group (WEG), and 10 in the deep-sea water exercise group (DSWEG). The DSWTT treatment consists of three components—preheating, treatment, and cooling—and the DSWTT program stretches and massages the entire upper body, lower body, back, and the entire body for a total of 25 min in a deep-sea tank. After the DSWTT program, blood tests were conducted to confirm the level of fatigue-related parameters and muscle damage enzymes. Fatigue-related parameters including glucose, lactate, ammonia, and lactate dehydrogenase (LDH), and the levels of muscle damage enzymes such as creatinine kinase (CK) and aspartate aminotransferase (AST) were measured. The results revealed that fatigue had a primary effect (p < 0.001) and exhibited strongly significant interaction (p < 0.001) with lactate, ammonia, and LDH levels, whereas the glucose level remained unchanged. The post hoc results showed a significant decrease in these parameters among DSWEG compared to CG and WEG (p < 0.01). Muscle damage enzymes showed a main effect (p < 0.001) and significant interaction (p < 0.001) with CK and AST (p < 0.001). The post hoc results showed a significant decrease in DSWEG compared with CG and WEG (p < 0.01). In conclusion, the DSWTT program applied to this study showed significant effects on muscle fatigue and muscle damage recovery. When the DSWTT program is applied in hot springs, it can have a positive effect on muscle fatigue and muscle damage recovery and can contribute to improving national health and quality of life. Further studies are needed to investigate DSWTT programs with various research subjects at different program temperatures, exercise times, and frequencies of treatment and exercise.
Surface Thermodynamics, Viscosity, Activation Energy of N-Methyldiethanolamine Aqueous Solutions Promoted by Tetramethylammonium Arginate
Authors: Tian Xiangfeng , Wang Lemeng , Zhang Pan , Fu Dong
Published: November 2020

The surface tension and viscosity values of N-methyldiethanolamine (MDEA) aqueous solutions promoted by tetramethylammonium arginate ([N1111][Arg]) were measured and modeled. The experimental temperatures were 303.2 to 323.2 K. The mass fractions of MDEA (wMDEA) and [N1111][Arg] (w[N1111][Arg]) were 0.300 to 0.500 and 0.025 to 0.075, respectively. The measured surface tension and viscosity values were satisfactorily fitted to thermodynamic models. With the aid of experimentally viscosity data, the activation energy (Ea) and H2S diffusion coefficient (DH2S) of MDEA-[N1111][Arg] aqueous solution were deduced. The surface entropy and surface enthalpy of the solutions were calculated using the fitted model of the surface tension. The quantitative relationship between the calculated values (surface tension, surface entropy, surface enthalpy, viscosity, activation energy, and H2S diffusion coefficient) and the operation conditions (mass fraction and temperature) was demonstrated.
The Effective Use of Information Technology and Interactive Activities to Improve Learner Engagement
Authors: Ullah Abrar , Anwar Sajid
Published: November 2020

Student engagement in the learning process is the key to successful delivery of teaching and learning. Teachers face several challenges to engage learners in different disciplines, including computer science. This research conducts a review of BSc (Computer Science) programmes and introduces interactive activities to enhance learner engagement. The study was conducted using a repeated measure design involving 24 participants. The findings revealed that the use of technology, and collaborative and interactive activities in groups may positively influence learner engagement. The participants’ feedback before and after introduction of group tasks and interactive activities showed a significant (p < 0.001) and increasing trend in response to questions-related learner engagement. The participants agreed that their learning experience and engagement enhanced with the use of technology and interactive and collaborative activities.
Closed Form Solutions for Predicting Lateral Response of Tripod Suction Pile for Offshore Wind Turbine Foundation
Authors: Ryu Moo-Sung , Jung Min-Uk , Lee Jun-Shin , Kim Dong-Soo
Published: November 2020

This study presents a simplified analysis technique capable of predicting the dynamic behavior of a tripod suction pile subjected to a horizontal load. The first natural frequency of the system, horizontal displacement, and allowable rotation angle at the pile head were set as target physical quantities in accordance with substructure design requirements. In consideration of the physical characteristics of the tripod suction pile, the analysis was extended to the single pile-multi-pile-tripod-tower part to derive the influence factors. A possible displacement response function that could be applied to the intermediate pile range was also proposed. Thereafter, a detailed design was determined using an integrated load analysis, which included a turbine based on the basic design of simplified analysis method. Furthermore, the dynamic behavior of the offshore wind turbine at each installation stage was predicted using a numerical analysis and measured via field tests. The displacement at the pile head and the predicted value of the first natural frequency of the system were compared using the field-measured and numerical analysis values. The first natural frequency value produced by the simple analysis method showed an error range within 1%, and the displacement at the pile head also satisfied the structural design requirements. Therefore, this method provides a quick and accurate solution to the lateral response of tripod suction piles as foundations for offshore wind turbines.
Analysis on the Thermal Balance and Operational Parameters for the District Heating System with Peak Load Boilers in Heating Substations
Authors: Li Xiangli , Wang Haichao , Wu Xiaozhou , Duanmu Lin , Teppo Esa , Lahdelma Risto , Li Ji , Yu Li
Published: November 2020

This study proposes to use gas-fired boilers as peak shaving heat sources in heating substations due to their capability to increase the reliability, flexibility and heat capacity without the need to change the district heating network (DHN). However, the design and operational requirements with different connection modes for this kind of DH system are still not clear. This paper presents a systematic study on this kind of DH system, analyzes the connection modes of series and parallel connections between the gas-fired boilers and the heat exchangers. For each connection mode, we figured out the thermal balances and obtained the design and operational parameters including the supply temperatures of the heat exchangers, gas-fired boilers and their variations under different network temperature levels and the base load ratios (β). Under the series connection mode, the design supply temperature of the heat exchangers has no relation with the design peak shaving flow ratio (ω′); it decreases linearly along with smaller β, and the decreasing slope is higher with bigger temperature difference (Δt) of the DHN. However, the design supply temperatures of gas-fired boilers increase linearly when β and/or ω′ are smaller, and the increasing speed is proportional to Δt. For the parallel connection mode, the design supply temperatures of the heat exchangers and gas-fired boilers are all affected by β, ω′ and Δt. The former decreases when β and/or ω′ are smaller, while the latter increases at the same time. Finally, the design peak shaving flow ratio ω′ are determined for the peak boilers with series and parallel connection modes. The study provides a theoretical basis for the design and operation of the DH system with peak heating boilers in substations in order to reach a lower investment and higher efficiency.
Point and Interval Forecasting of Zonal Electricity Prices and Demand Using Heteroscedastic Models: The IPEX Case
Authors: Bernardi Mauro , Lisi Francesco
Published: November 2020

Since the electricity market liberalisation of the mid-1990s, forecasting energy demand and prices in competitive markets has become of primary importance for energy suppliers, market regulators and policy makers. In this paper, we propose a non-parametric model to obtain point and interval predictions of price and demand. It does not require any parametric assumption on the distribution of the error term or on the functional relationships linking the response variable to covariates. The assumed location–scale model provides a non-parametric estimation of the conditional mean and of the conditional variance by means of a Generalised Additive Model. Interval forecasts, at any given confidence level, are then obtained using a further non-parametric estimation of the innovation’s quantile. Since both the conditional mean and the conditional variance of the response variable are non-linear functions of covariates depending on calendar factors, renewable energy productions and other market variables, the resulting model is very flexible. It easily adapts to market conditions as well as to the non-linear characteristics of demand, supply and prices. An application to hourly data for the Italian electricity market, over the period 2015–2019 period, shows the one-day-ahead forecasting performance of the model for zonal electricity prices and level of demand.
Gradient Heatmetry Advances
Authors: Sapozhnikov Sergey Z. , Mityakov Vladimir Y. , Mityakov Andrey V. , Gusakov Andrey A. , Zainullina Elza R. , Grekov Mikhail A. , Seroshtanov Vladimir V. , Bashkatov Alexander , Babich Alexander Y. , Pavlov Andrey V.
Published: November 2020

The paper describes a unique method of heat flux measurement, i.e., gradient heatmetry. Gradient heatmetry is performed using gradient heat flux sensors (GHFS) developed on the anisotropic thermoelements basis. The principle of GHFS’ operation leads to the fact that their response time is about 10 ns, and the volt-watt sensitivity does not depend on the thickness. GHFS are compared with other types heat flux sensors, with the GHFS features depending on the materials being described. The theory and examples of gradient heatmetry applications in thermophysical experiment are provided.
Three-Dimensional Imaging and Quantification of Gas Storativity in Nanoporous Media via X-rays Computed Tomography
Authors: Elkady Youssef , Lyu Ye , Jessen Kristian , Kovscek Anthony R.
Published: November 2020

This study provides the engineering science underpinnings for improved characterization and quantification of the interplay of gases with kerogen and minerals in shale. Natural nanoporous media such as shale (i.e., mudstone) often present with low permeability and dual porosity, making them difficult to characterize given the complex structural and chemical features across multiple scales. These structures give nanoporous solids a large surface area for gas to sorb. In oil and gas applications, full understanding of these media and their sorption characteristics are critical for evaluating gas reserves, flow, and storage for enhanced recovery and CO2 sequestration potential. Other applications include CO2 capture from industrial plants, hydrogen storage on sorbent surfaces, and heterogeneous catalysis in ammonia synthesis. Therefore, high-resolution experimental procedures are demanded to better understand the gas–solid behavior. In this study, CT imaging was applied on the sub-millimeter scale to shale samples (Eagle Ford and Wolfcamp) to improve quantitative agreement between CT-derived and pulse decay (mass balance) derived results. Improved CT imaging formulations are presented that better match mass balance results, highlighting the significance of gas sorption in complex nanoporous media. The proposed CT routine implemented on the Eagle Ford sample demonstrated a 17% error reduction (22% to 5%) when compared to the conventional CT procedure. These observations are consistent in the Wolfcamp sample, emphasizing the reliability of this technique for broader implementation of digital adsorption studies in nanoporous geomaterials.
Techno-Cultural Factors Affecting Policy Decision-Making: A Social Network Analysis of South Korea’s Local Spatial Planning Policy
Authors: Park Eun Soo , Lee An Yong
Published: November 2020

Increasing interest in various local construction forms necessitate examining its link to human life. Construction culture should be adapted and applied to the contemporary context to create a harmonious coexistence with diverse local cultures and to strengthen regional sustainability, avoiding the rigid, one-dimensional local construction development. Thus, this study aims to analyze the factors of influence needed for policy decision-making at the local spatial planning stage, with regional technologies and cultural contents from a convergent perspective taken into consideration. This study derived tangible and intangible policy decision-making factors during the spatial planning stage using text mining analysis. Additionally, social network analysis was also used to seek multi-angle correlations among factors. Through big data analytics, 16 key decision-making contents in the spatial planning stage were derived, with ‘regional development, urban policy’ as most influential. Such a result indicates the need for regional and urban policy engagement with strategic development from a holistic perspective—in view of socio-cultural relations and forms of change—and local perceptions of spatial value and significance affecting decision-making in the local spatial planning stage (LSPS). Understanding the decision-making process in the spatial planning stage requires a holistic approach with both visible technological factors (structure, form, and construction method) and invisible cultural factors (ways of life projected during space formation, zeitgeist, religion, learning, and art) included.
Dimensions of Leisure and Perceived Health in Young University Students
Authors: Andrés-Villas Montserrat , Díaz-Milanés Diego , Remesal-Cobreros Raquel , Vélez-Toral Mercedes , Pérez-Moreno Pedro J.
Published: November 2020

The aim of this study was to analyze the main leisure habits of students at the University of Huelva and the relationship with perceived health by grouping the various activities into components whilst also evaluating possible gender differences. The sample was selected through random cluster sampling and was composed of 903 students from various courses and degrees. Of the sample, 73.8% were female and 26.2% were male, with a mean age of 20.82 years. The participants responded to items measuring perceived health and the inventory of leisure activities extracted from the INJUVE (Spanish Youth Observatory) survey. The results obtained offered a solution of four components, grouping the activities into passive leisure, festive leisure, sports–competitive leisure and cultural leisure. Passive leisure was the most practiced and cultural leisure the least practiced. Statistically significant differences were observed between men and women in terms of the sports–competitive component and in the perception of health. In addition, a direct relationship was found between the sports–competitive dimension and health perception. These results support the existence of a “techno-active” profile in males and should be considered in the creation of university policies linked to health promotion or the prevention of risk behaviors.
Community Pharmacies in Poland—The Journey from a Deregulated to a Strictly Regulated Market
Authors: Wiśniewski Marcin , Religioni Urszula , Merks Piotr
Published: November 2020

Community pharmacies are the primary entities providing drugs to individual patients in Poland. The pharmacy market has been changing for many years due to significant changes in market regulations. These changes significantly affect the profitability of pharmacies, which may impact the quality of pharmacotherapy. The small number of pharmacies, which resulted from changes in the law in 2017, can influence the level of patient care. The article presents the community pharmacies market in Poland. Particular attention is paid to the legal regulations affecting community pharmacies and the impact of these regulations on the overall shape of the market. The Polish system’s specificity, including the pharmacy market indicators, has been compared with data from other European Union countries.
Development and Pretesting of Hookah Tobacco Public Education Messages for Young Adults
Authors: Phan Lilianna , Villanti Andrea C. , Leshner Glenn , Wagener Theodore L. , Stevens Elise M. , Johnson Andrea C. , Mays Darren
Published: November 2020

Young adults’ hookah tobacco use is fueled by misperceptions about risks, appealing flavors, and social use. We developed and pretested public education messages to prevent and reduce hookah tobacco smoking among young adults. We used a two (user status: current hookah user, susceptible never user) by two (risk content: health harms or addiction) by three (message theme: harms/addiction risk alone, harms/addiction risk flavors, or harms/addiction risk social use) design with two messages/condition (n = 12 total messages). Young adults aged 18–30 (N = 713) were randomized to 1 of 12 messages and completed measures assessing message receptivity, attitudes, and negative emotional response. Harms messages were associated with greater receptivity (p < 0.001), positive attitudes (p < 0.001), and negative emotional response (p < 0.001) than addiction messages. Messages with harm or addiction content alone were associated with greater receptivity than social use-themed messages (p = 0.058). Flavor-themed messages did not differ in receptivity from harm or addiction content alone or social use-themed messages. Messages about the health harms of hookah tobacco use resonate more with young adults than addiction risk messages. Social use-themed messages produce the lowest receptivity. These findings can guide population-based approaches to communicate hookah tobacco risks to young adults.
Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride
Authors: Ort Jonas , Kremer Benedikt , Grüßer Linda , Blaumeiser-Debarry Romy , Clusmann Hans , Coburn Mark , Höllig Anke , Lindauer Ute
Published: November 2020

Effective pharmacological neuroprotection is one of the most desired aims in modern medicine. We postulated that a combination of two clinically used drugs—nimodipine (L-Type voltage-gated calcium channel blocker) and amiloride (acid-sensing ion channel inhibitor)—might act synergistically in an experimental model of ischaemia, targeting the intracellular rise in calcium as a pathway in neuronal cell death. We used organotypic hippocampal slices of mice pups and a well-established regimen of oxygen-glucose deprivation (OGD) to assess a possible neuroprotective effect. Neither nimodipine (at 10 or 20 µM) alone or in combination with amiloride (at 100 µM) showed any amelioration. Dissolved at 2.0 Vol.% dimethyl-sulfoxide (DMSO), the combination of both components even increased cell damage (p = 0.0001), an effect not observed with amiloride alone. We conclude that neither amiloride nor nimodipine do offer neuroprotection in an in vitro ischaemia model. On a technical note, the use of DMSO should be carefully evaluated in neuroprotective experiments, since it possibly alters cell damage.