bluuebunny/crossref_metadata_2025 huggingface dataset:
Coloring mixed QCD/QED evolution
Authors: Gellersen Leif , Prestel Stefan , Spannowsky Michael
Published: August 2022

Parton showers are crucial components of high-energy physics calculations. Improving their modelling of QCD is an active research area since shower approximations are stumbling blocks for precision event generators. Naively, the interference between sub-dominant Standard-Model interactions and QCD can be of similar size to subleading QCD corrections. This article assesses the impact of QCD/QED interference effects in parton showers, by developing a sophisticated shower including QED, QCD at fixed color, and employing complete tree-level matrix element corrections for individual N_C=3NC=3 color configurations to embed interference. The resulting simulation indicates that QCD/QED interference effects are small for a simple test case and dwarfed by electro-weak resonance effects.
Koyun Dalak Dokusundan Saflaştırılan Glukoz-6-Fosfat Dehidrogenaz ve Glutatyon Redüktaz Enzimi Üzerine Diklofenak Sodyumun İn Vitro Etkileri
Authors: ÇOBAN Çiğdem , TEMEL Yusuf , ÇİFTCİ Mehmet
Published: August 2022

Bu çalışmada, artrit ve akut yaralanmalarda enflamasyonu önlemek ve ağrıyı dindirmek için kullanılan diklofenak sodyumun, koyun dalak dokusundan saflaştırılan glukoz-6-fosfat dehidrogenaz enzimi (G6PD; E.C. 1.1.1.49) ve glutatyon redüktaz enzimi (GR; E.C. 1.8.1.7) üzerine in vitro etkileri araştırıldı. Çalışmanın ilk aşamasında G6PD ve GR enzimleri koyun dalak dokusundan, amonyum sülfat (NH4)2SO4 çöktürmesi ve 2', 5' ADP-Sepharose-4B jel afinite kromatografisi ile saflaştırıldı. Enzimlerin saflık dereceleri sodyum dodesilsülfat poliakrilamid jel elektroforezi (SDS-PAGE) metodu ile kontrol edildi. Çalışmanın ikinci aşamasında saf olarak elde edilen enzim aktiviteleri üzerine diklofenak sodyumun etkileri araştırıldı. Enzimler üzerinde inhibisyon etkisi gösteren diklofenak sodyumun için % Aktivite-[I] grafiği çizilerek IC50 değerleri hesaplandı. Ayrıca beş farklı substrat konsantrasyonu ve üç farklı inhibitör konsantrasyonlarıyla ölçümler yapılarak Lineweaver-Burk grafikleri çizildi. Elde edilen bu grafiklerden diklofenak sodyumun G6PD enzimini 0.51 mM, IC50 değeri ve 0.48 ± 0.01 mM Ki değeri ile yarışmasız olarak inhibe ettiği belirlendi. GR enzimini ise 6.55 mM IC50 değeri ve 15.69 ± 0.84 mM Ki değeri ile yarışmasız olarak inhibe ettiği tespit edildi.
Investigation of Prospective Science Teachers’ Answers to Multiple Choice Questions about Star: Analysis Wrong Answers as well as Corrects
Authors: Ezberci Çevik Ebru , Kurnaz Mehmet Altan
Published: August 2022

The aim of the research is to obtain information about the modeling status of the related science subject by making a concentration analysis of the answers given by the prospective science teachers to the multiple choice questions about the star. The quantitative research method was used in this study. The study group of the research consists of 73 prospective teachers studying at the senior year of the Science Education department of a university in the Western Black Sea Region. Data collection tool "Star Subject Concept Test (SSCT)" was used. The data were analyzed by concentration analysis. In this sense, concentration score, concentration factor and concentration deviation formulas are used. In line with the findings obtained, it was determined that there was LL type modeling in the pretest in prospective teachers, and posttest showed that HH modeling was common in the questions. In the light of the results obtained, suggestions were made to evaluate this situation before teaching and to analyze the effectiveness of different teaching methods.
T-Box Transcription Factor 2 Enhances Chemoresistance of Endometrial Cancer by Mediating NRF2 Expression
Authors: Zhuang Shichao , Ding Ning , Zhang Ting , Yu Xiaohui
Published: August 2022

Background:

The roles of T-Box transcription factor (TBX2) in endometrial cancer are still not clear. This study was designed to explore the roles of TBX2 in endometrial cancer and the underlying mechanisms.

Methods:

The knockdown and overexpression of TBX2 in endometrial cancer cell lines were constructed by using lentivirus transduction. The xenograft animal model was established by using stable endometrial cancer cell lines. Cell viability was determined by the CCK-8 assay. The mRNA and protein levels of target genes were determined by using qPCR and Western blotting, respectively. ChIP assay was used to determine the interactions between TBX2 and nuclear factor erythroid 2-related factor 2 (NRF2).

Results:

The upregulation of TBX2 was observed in endometrial cancer tissues from patients with Cisplatin-resistance and Cisplatin-resistant cells. Interestingly, TBX2 regulated cell viability and Cisplatin resistance of endometrial cancer cells. In addition, the regulatory effects of TBX2 on chemo-resistance of endometrial cancer cells were associated with the NRF2 signaling pathways. Consistently, the endometrial cancer xenograft animal model revealed that TBX2 regulated tumor growth and Cisplatin resistance, and its regulatory effects were in part by the regulation of NRF2 signaling pathways.

Conclusion:

TBX 2 enhanced Cisplatin resistance of endometrial cancer by regulating the NRF2 signaling pathways.
Comparative Bioavailability Study of a Novel Multi-Day Patch Formulation
of Rivastigmine (Twice Weekly) with Exelon® Transdermal Patch
(Daily)- A Randomized Clinical Trial
Authors: Schurad Bjoern , Koch Cornelius , Schug Barbara , Morte Adelaida , Vaqué Anna , De la Torre Rafael , Iniesta Marc
Published: August 2022

Background:

Rivastigmine, a reversible AChEI for symptomatic treatment of mild to moderately severe Alzheimer’s dementia is administered in once daily transdermal patches enabling an easier and continuous drug delivery. A novel multi-day (twice week) patch formulation with greater convenience for patients’ therapeutic management, was developed.

Objective:

To assess the bioequivalence under SS conditions of the multiple-day rivastigmine transdermal patch (Test Product, RID-TDS) in comparison to the once daily Exelon® transdermal patch (Reference Product), both at a release rate of 9.5 mg/24 h.

Design:

Single center, open-label, randomized, multiple dose study in healthy male adults in a 2-period, 2-sequence-crossover design with multiple applications.

Methods:

Patches were applied on 11 consecutive days for Exelon® and 4-3-4-day regimen for the multiday test patch (RID-TDS), separated by a 14-day wash-out period. The safety, local tolerability and inhibitory effect of rivastigmine on plasma BuChE activity were also evaluated.

Results:

57 subjects completed the study according to the protocol. Calculated point estimates and 90% CI for all primary parameters (AUC96-264, Cmax96-264 and Cmin96-264) were within the predefined acceptance interval of 80.00 – 125.00%. They were 113.64% (107.33 – 120.33), 105.14% (98.38 – 112.38) and 107.82% (97.78 – 118.89) respectively. Satisfactory adhesion (CI of mean adhesion above 90%) was demonstrated for RID-TDS but not for Exelon®.

Conclusion:

Bioequivalence was demonstrated between RID-TDS mg twice a week and Exelon® once a day in SS. Patch adhesion favored RID-TDS despite the longer dosing interval. Both products were well tolerated.

Trial Registration number:

Protocols are registered in ClinicalTrials.gov: NCT03659435 and EudraCT: 2018-001570-18
Elimination, Containment, and Mitigation of COVID-19: A Personal Story
about International Travels
Authors: Hon Kum L. , Leung Karen K.Y.
Published: August 2022

Background:

The author and his wife report their unique experience of international travels during the COVID-19 pandemic, and discuss issues encountered in various countries.

Methods:

Narrated discussion of issues encountered during the COVID-19 pandemic.

Discussion:

“Zero-COVID” versus “Living with COVID-19” strategies are compared. Children have unique issues with COVID-19 pandemic. Evaluation of efficacy of the approaches in pandem-ic with time should consider the main types of interventions (e.g., border management/quarantine; physical distancing; mask use; case isolation, testing and contact tracing; vaccination). The key met-rics that can be used to compare the impacts of different strategies between the cities (e.g., cumula-tive case rate, cumulative mortality rate, case fatality risk, stringency index, economic performance) should be identified. Research in these approaches can help manage future pandemics in corona-viruses and emerging infections. The UK started with very loose mitigation ('herd immunity') and then switched to a suppression approach in 2021, followed by "living with the virus" approach. Whereas HK has been targeting towards elimination throughout. In between, countries like Singa-pore, Australia and New Zealand have shifted from zero-COVID strategy to living with the virus. It is easier to have effective social control measures in Hong Kong because it has clear borders and an authoritarian government, but it did not have a clear exit policy when Omicron spread.
Review of Randomized Controlled Trials in Patients with Peripartum
Cardiomyopathy
Authors: Mujkanovic Jasmin , Qayyum Abbas Ali
Published: August 2022

Introduction:

Peripartum cardiomyopathy (PPCM) is a rare but potentially life-threatening disease, defined as idiopathic cardiomyopathy occurring towards the end of pregnancy or in the months following delivery, abortion or miscarriage. We aim to raise awareness of this condition and give an overview of current knowledge as well as an insight and comparison of clinical trials focusing on randomized controlled trials.

Material and methods:

Systematic literature searches were conducted using PubMed up to December 2021. Studies published involving clinical trials and interventions in women with PPCM after 1970 were selected.

Results:

Randomized controlled trials have shown that addition of Bromocriptine to standardized heart failure therapy improves outcome in terms of recovery of left ventricular ejection fraction (LVEF), symptoms and death. Bromocriptine 2.5 mg twice daily for two weeks followed by 2.5 mg once daily for six weeks had the best trend anAddition of Levosimendan to standardized heart failure therapy had no effect, whereas addition of Selenium had an improvement in heart failure symptoms but did not reduce risk in terms of unrecovered LVEF or death. One prospective study showed a potential usage of TNF-alfa inhibitors, but was never tried in a randomized clinical trial.d outcome.

Conclusion:

PPCM is a rare and potentially fatal disease. New insights in pathophysiology, genetics and clinical studies, particularly randomized controlled trials have shown that addition of Bromocriptine has a beneficial effect in terms of improved LVEF and death. However, some clinical studies have shown promising results using anti-inflammatory pharmacological agents with an improvement in LVEF. We suggest that targeting an anti-inflammatory route may prove beneficial in patients with PPCM. However, further research is highly warranted.
Magnetic Resonance Imaging Features and Misdiagnosis of Spinal Epidural
Cavernous Hemangioma
Authors: Xiao Meng-Qiang , Zhang Meng , Ye Jing-Zhi , Li Hong-Yi , Huang Pei-Kai , Chen Jun , Liu Jing-Feng
Published: August 2022

Objective:

Spinal epidural cavernous hemangiomas (SECHs) are rare, and merely a few
have previously been described in case reports. The present study aims to explore the magnetic resonance imaging (MRI) features of SECHs and analyze the causes of their preoperative misdiagnosis.

Methods:

The present retrospective study included 11 patients (three male and eight female patients,
mean age ± standard deviation: 47.55±17.39 years old) with histopathologically confirmed SECH between January 2015 and April 2021. The MRI features of SECH were analyzed by two radiologists.

Results:

The cervical, thoracic and thoracolumbar segments were involved in 2, 7 and 2 patients, respectively. All lesions grew along the long axis of the spine. The tumors were shuttle-shaped in six
patients, oval in two patients, pseudopodia-shaped in one patient, clamp-shaped in one patient, and
growing outward along the intervertebral foramen in one patient. Nine SECHs had relatively uniform
isointense or hypointense T1-weighted imaging (T1WI) and hyperintense T2-weighted imaging
(T2WI) signals. On the T2WI, filamentary low-signal shadows (i.e., the hairline or grid sign) with
significant contrast enhancement and asymptotic strengthening were observed. Two SECHs had mixed
high and low signals on T1WI and T2WI, with significant heterogeneous enhancement, hemorrhage,
and hemosiderin deposition. The SECH was misdiagnosed as meningioma, neurofibromatosis and
schwannoma in 1, 1 and 4 patients, respectively, while this was not diagnosed in one patient. The preoperative diagnosis was correct in merely approximately 36% of patients. Among the four patients
with a correct preoperative diagnosis, hemosiderin deposition was found in three patients and small
tortuous vascular shadows were found in one patient.

Conclusions:

SECH presents as a long spindle-shaped mass, and the “'pen cap sign” is common at the
lesion edges. SECH also exhibits a hairline or grid sign on T2WI. Furthermore, some lesions present
with hemorrhage and hemosiderin deposition. Therefore, the hairline, grid sign and hemosiderin deposition are valuable diagnostic features of SECH.
Current Approaches in Healing of Wounds in Diabetes and Diabetic Foot Ulcers
Authors: Gupta Sumeet , Chauhan Samrat , Chalotra Rishabh , Rathi Akshay , Saini Monika , Deol Shweta , Lard Mehak
Published: August 2022

Background:

Diabetes is a chronic disease affecting more than 8.5 % adult population
in the world. Among various issues caused by diabetes, wound healing is a major cause of concern.

Objective:

Injuries are most common, and can be caused normally by abrasion, laceration (cuts),
injury, etc. But in diabetes, they do not heal so easily and cause problems. It can be due to a compromised
immune system, neuropathy, poor circulation, infections etc., which could lead to amputation
or even death. Current therapies for the treatment of wound healing in diabetic patients, have
side effects of their own, as there is no particular drug for the healing of wounds.

Methods:

Numerous surveys in literature were carried out to reveal the obstacles in diabetic
wound healing and current approaches to its management with emphasis on alternative therapies.
Relevant peer-reviewed research publications were searched through various online bibliographic
databases such as ScienceDirect, PubMed, Scopus, Google Scholar, and ResearchGate (all
English-language articles).

Results:

Repurposed drugs include a class of statin, phenytoin, estrogen, and DPP4 inhibitors.
Plants with wound healing activity include Rosmarinus officinalis, Radix Rehmannia, Carica papaya,
Aloe vera, Catharanthus roseus, Punica granatum, etc. have been explored in pre-clinical
studies. Besides these studies, a lot of other studies, including clinical trials, have been performed
for wound healing in diabetes by using different procedures like Honey-dressing, Royal Jelly, Extracorporeal
Shock wave therapy, Manuka honey-impregnated dressing, LeucoPatch system, etc.

Conclusion:

In this review, an approach was made to study wound healing in diabetes and various
options that could be best suited for the treatment of wounds in diabetes.
Recent Advancements in Herbal Bioactive-based Nanoformulations for the
Treatment of Psoriasis
Authors: Rath Goutam , Biswasroy Prativa , Pradhan Deepak , Haldar Jitu , Kar Biswakanth , Ghosh Goutam
Published: August 2022

Psoriasis is a multifaceted inflammatory dermatological skin disease characterized by Tcell
(T-lymphocyte) activation, hyperproliferation, and abnormal epidermal keratinocyte differentiation.
Natural bioactive agents from plants including Psoralea corylifolia, Nigella sativa, Curcuma
longa, Capsicum annum, Smilax china, Woodfordia fructicosa, and others have recently gained a
lot of attention for their anti-psoriatic properties. However, inadequate drug absorption, lack of
specificity in drug release, and unintended skin reactions largely restrict their clinical efficacy.
Nanoformulations improve the pharmacodynamic characteristics that overcome drug delivery challenges
and enhance the anti-psoriatic activity. Nanostructured systems such as liposome, ethosome,
liposphere, and others have been reported to improve plant extract solubility, penetration, bioavailability,
bioactivity, and minimize undesirable effects, providing the way for the development of
herbal nanoformulation. This review enlights the therapeutic efficacy of lead phytocompounds and
its nanoformulations in managing psoriasis.
The Glucose-Regulated Protein78 (GRP78) in the Unfolded Protein Response (UPR)
Pathway: A Potential Therapeutic Target for Breast Cancer
Authors: Karimabad Mojgan Noroozi , Sadeghipour Maryam Mohammad , Torabizadeh Seyedeh Atekeh
Published: August 2022

Amongst all types of cancers, breast cancer is recognized as the most common cancer and a principal cause
of morbidity and mortality in women. Endoplasmic reticulum (ER) stress pathways are primarily activated in cancer
cells and activate a signaling network called the unfolded protein response (UPR). Many tumors, by activating the UPR
pathway, allow them to adapt and grow under stressful conditions. UPR is usually inactive in non-tumor cells, while it
is active in tumor cells, so it is appropriate to develop new breast cancer therapies. A protein that regulates UPR is 78
KDa Glucose-Regulated Protein (GRP78). Usually, the GRP78 level in the cell is relatively low but increases significantly
under stresses that affect the ER and calcium homeostasis, and increases resistance to chemotherapy. GRP78
drug suppressors could provide promising anticancer therapeutics. Therefore, understanding the molecular mechanism
of GRP78 in cancer and identifying drugs that target GRP78 is essential for the treatment of breast cancer. In this review,
we investigate the role of GRP78 in the pathogenesis of breast cancer.
High Prevalence of Panton-valentine Leukocidin-encoding Genes in
Methicillin-resistant Staphylococcus aureus Isolated from Inpatients with
Invasive Infections at a University Hospital in Southern Brazil
Authors: Yamada-Ogatta Sueli Fumie , da Silva Raquel Soares , Duarte Felipe Crepaldi , Danelli Tiago , Olak Anna Paula Silva , Magalhães Gerusa Luciana Gomes , Pelisson Marsileni , Cardim Stefani Lino , Gonçalves Guilherme Bartolomeu , Vespero Eliana Carolina , Tavares Eliandro Reis , Yamauchi Lucy Megumi , Perugini Marcia Regina Eches
Published: August 2022

Background:

Staphylococcus aureus is a major cause of a wide diversity of infections in humans, and the expression of Panton-Valentine Leukocidin (PVL) has been associated with severe clinical syndromes.

Objectives:

The present study aimed to investigate the prevalence of PVL-encoding genes in S. aureus isolated from clinical samples of inpatients with invasive infections in a teaching hospital in Southern Brazil. Furthermore, phenotypic and genotypic characteristics of bacterial isolates were analyzed.

Methods:

A total of 98 S. aureus isolates recovered from different body sites were characterized according to their antimicrobial susceptibility profile, methicillin-resistance and SCCmec typing, genetic relatedness and occurrence of virulence-encoding genes such as icaA, lukS-PV/lukF-PV and tst.

Results:

Sixty-eight (69.4%) isolates were classified as methicillin-resistant and among them, four (5.9%) did not harbor the mecA gene. The mecA-harboring methicillin-resistant S. aureus (MRSA) isolates were grouped into SCCmec types I (6.3%), II (64.1%), III (6.3%), IV (15.6%), V (4.7%), and VI (1.6%). One isolate (1.6%) was classified as non-typeable (NT). Seventy isolates (71.4%) were classified as multidrug-resistant. The overall prevalence of virulence-encoding genes was as follows: icaA, 99.0%; tst, 27.5%; and lukS-PV/lukF-PV, 50.0%. The presence of tst gene was significantly higher (p < 0.001) in methicillin-susceptible S. aureus (MSSA) compared to MRSA isolates.

Conclusion:

The present study reports a high prevalence of multidrug-resistant S. aureus harboring lukS-PV/lukF-PV and tst genes in invasive infections. The continuous monitoring of the antimicrobial susceptibility profile and virulence of S. aureus is an important measure for the control of infections caused by this bacterium.
WITHDRAWN: Poloxamer and gelucire solid dispersion prepared by solvent evaporation; an effective means for solubility enhancement of tinidazole
Authors: Ahirrao Sapana , Kale Durgesh , Bhambere Deepak , Kuber Dinesh
Published: August 2022

Background:

Many BCS Class II and IV drugs possess high therapeutic potential but shows less bioavailability due to poor solubility. Hence present study is focused on improvement of solubility and dissolution rate of poorly soluble drug; tinidazole.

Methods:

Solid dispersion of tinidazole were prepared with gelucire and poloxamer using various methods; kneading, fusion and solvent evaporation. Formulations were evaluated by saturation solubility, drug content, in vitro dissolution rate, FTIR, DSC, XRD and stability study. Optimised solid dispersions of gelucire and poloxamer provided dissolution rates faster than that of pure drug.

Results:

In vitro dissolution studies revealed that formulation batch Sg14 shows 94.43 percent drug release with a correlation coefficient (R²) of 0.949 and batch Sp14 shows 97.69 percent drug release with a correlation coefficient (R²) of 0.993. DSC study revealed that there was no interaction between drug and carrier whereas the XRD study of optimised formulation batches demonstrates that there was a significant decrease in crystallinity when compared with XRD pattern of pure drug tinidazole. Significant change in solubility and in vitro dissolution rate of tinidazole would be due to amorphous state maintained in the optimised formulation batches.

Conclusion:

Hence overall formulation and evaluation studies of present research work indicate that solid dispersion by solvent evaporation method is an effective means to improve the solubility of tinidazole.
Sustainable Composites Based on Natural Rubber and Biomass Resources
Authors: John Maya Jacob , Thomas Martin George , Vidhu Hanna , Thomas Sabu
Published: August 2022

For the past two decades, environmentally friendly natural rubber composites and nanocomposites reinforced with renewable and biodegradable natural fillers has attracted increasing attention of polymer researchers from both industrial and environmental viewpoints. The use of bio-based fillers in rubber materials has emerged as extremely promising in the progress of green rubber technology. The dispersion of bio-based fillers within the rubber matrix is the key parameter that decides the overall performances of bio-based rubber composites. An important criterion for obtaining superior properties in rubber composites is good interfacial adhesion between natural fillers and natural rubber matrix, along with good dispersion and distribution of fillers within the matrix. Natural fillers represent materials that are environmentally friendly, easily available, comprising of valuable lignocellulosic fractions and are from a bio-based feedstock. Recent developments in this area focus on renewable fillers such as cellulose, chitin and lignin in its micro and nanoforms. Additionally, recent studies have focused on the use of different type of biomass residue wastes in rubber composites with a view to adapt to the recent circular economy principles. This review presents an overview of various studies and highlights in the area of bio-based filler reinforced natural rubber composites and also discusses the applications of such materials in industrial sectors.
A Mixed-Methods Pilot Study to Identify Facilitators Leading to Sustained Mindfulness Practice across the Perinatal Period
Authors:   Department of Community and Behavioral Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States, Walls Jessica , Farewell Charlotte V. ,   Department of Community and Behavioral Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States, Traikoff Kara ,   Department of Community and Behavioral Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States, Burns Haley ,   Department of Community and Behavioral Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States, Whalen Joanne ,   Integrative Medicine Center, UC Health, Denver, Colorado 80238, United States, Shefferman Meredith ,   Integrative Medicine Center, UC Health, Denver, Colorado 80238, United States, Leiferman Jenn A. ,   Department of Community and Behavioral Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States
Published: August 2022

Many women experience depression and/or anxiety during pregnancy and/or the postpartum period. Mind-Body Interventions (MBIs) have shown great efficacy in the mitigation of these symptoms; however, there is limited research spanning the postpartum period and exploring long-term sustainability of mindfulness practice. Furthermore, little is known about specific facilitators that contribute to sustainability. The primary objective of this mixed-methods study is to use the Theory of Planned Behavior (TPB) framework to inform multi-level factors associated with the sustainability of mindfulness practices and associated mental health outcomes in the postpartum period after participating in a prenatal MBI to inform and improve future interventions. Measures of mental health including depression, anxiety, and perceived stress were evaluated via quantitative assessments at three time points (n = 24) across the prenatal and postpartum periods prior to and following the prenatal MBI. Interviews were conducted post-intervention (n = 10) and 5-12-months postpartum (n = 8) to identify sustainability facilitators. Measures of depression, anxiety, and perceived stress were significantly lower post-intervention than pre-intervention, and decreased levels of depression were sustained over three months postpartum. After participation, all interview participants reported intention to continue practice postpartum. In the postpartum period, 73% of participants reported weekly sustained practice. Qualitative interviews revealed significant facilitators to be informal practice (attitudes and beliefs), family and peer support (social norms), life-integration and self-compassion (perceived control) and benefits to child (intentions/ behaviors). These findings suggest that future interventions should focus on ease of integrating informal practice into daily routines, communication with support systems, self-compassion, and benefits of mindfulness practices for the child to promote sustainability.
Effect of lyophilized porcine plasma and Zaragoza bean (Phaseolus vulgaris) flour on the technological and sensory quality parameters of frankfurter-type sausages
Authors: Montero Castillo Piedad Margarita , Martelo Gómez Raúl José , Paternina Sierra Katherine
Published: August 2022

Trends in healthy foods have influenced the meat sector in general, so producers are catering to these needs using functional ingredients to complement the benefits of animal protein. This study evaluates the effect of incorporating lyophilized porcine plasma and Zaragoza bean (Phaseolus vulgaris) flour on the quality of frankfurter-type sausages at different concentrations. A 2x2 factorial design was used, where the independent variables were the lyophilized plasma content and the amount of Zaragoza bean flour. Acceptability, proximal composition, texture, cooking losses, and water retention capacity were the dependent variables. T4 (1.5 % plasma and 5 % flour) obtained the highest acceptability because of its proximal composition (20.41 % protein, 62.42 % moisture, 10.12 % fat, and 4.76 % ashes). In turn, this treatment obtained better textural characteristics than the control, lower cooking losses (2.02 %), higher yield (98.18 %), and water retention capacity (8.8 %), possibly attributed to the functional properties of plasma and flour. This study demonstrates that incorporating porcine plasma and Zaragoza bean flour into meat products such as Frankfurt sausages is possible without hurting acceptability. It also confirms the positive impact on these meat products’ acceptability, proximal composition, texture, cooking losses, and water retention capacity.
Time Spent on Instagram and Body Image, Self-esteem, and Physical Comparison Among Young Adults in Spain: Observational Study (Preprint)
Authors: Alfonso-Fuertes Isabel , Alvarez-Mon Miguel Angel , Sanchez del Hoyo Rafael , Ortega Miguel A , Alvarez-Mon Melchor , Molina-Ruiz Rosa M
Published: August 2022

BACKGROUND

Instagram is a social media platform based on photos and videos that encourages interaction and comparison between users. Its growing popularity, especially among young people, has generated interest in the impact its use can have on users´ mental health, specifically on their self-esteem and degree of satisfaction with their own body image.

OBJECTIVE

We aimed to analyze the relationships between the use of Instagram, both the hours of daily use and the type of content viewed, and self-esteem, tendency to make physical comparisons, and satisfaction with body image.

METHODS

In this cross-sectional study, we recruited 585 participants aged between 18 years and 40 years. Individuals who were interested in participating but had a personal history of eating disorders or had previously been diagnosed with a psychiatric disorder were excluded. The assessment tools consisted of (1) a questionnaire that collected sociodemographic data and Instagram use variables and was created by the research team specifically for this study; (2) the self-esteem scale by Rosenberg; (3) Physical Appearance Comparison Scale-Revised (PACS-R); and (4) Body Shape Questionnaire (BSQ). The recruitment and evaluation processes were carried out in January 2021.

RESULTS

Of the participants, 234 (234/585, 40%) used Instagram less than 1 hour a day, 303 (303/585, 51.8%) used Instagram between 1 hour and 3 hours a day, and 48 participants (48/585, 8.2%) used it more than 3 hours per day. We found statistically significant differences (P<.05) between the 3 groups in the scores obtained on the self-esteem test by Rosenberg, PACS-R, and BSQ. Participants who spent more time on Instagram had higher levels of body dissatisfaction, greater comparisons of physical appearance, and lower self-esteem. Moreover, we analyzed the relationship between the score obtained on the different scales and the types of content viewed, with no differences between those who mainly viewed professional content and those who primarily consumed fashion and beauty or sport and nutrition content.

CONCLUSIONS

The results of this study indicate that the use of Instagram is associated with poorer body image satisfaction and self-esteem, mediated by the tendency to compare physical appearance in relation to the daily duration of Instagram use.
Arterial Stiffness and Chronic Kidney Disease Progression in Children
Authors: Azukaitis Karolis , Kirchner Marietta , Doyon Anke , Litwin Mieczysław , Bayazit Aysun , Duzova Ali , Canpolat Nur , Jankauskiene Augustina , Shroff Rukshana , Melk Anette , Querfeld Uwe , Schaefer Franz
Published: August 2022

Background and objectives

CKD has been linked to increased arterial stiffness in adults, but data in children with CKD remain conflicting. We aimed to investigate the longitudinal dynamics and determinants of pulse wave velocity in children with CKD and its association with CKD progression.

Design, setting, participants, & measurements

We performed an analysis of the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study, which prospectively followed children aged 6–17 years with CKD stages 3–5. Follow-up was censored at the time of KRT initiation. Two separate analyses were performed: with absolute pulse wave velocity (primary outcome) and with pulse wave velocity standardized to height (z score; restricted to participants ≤17 years) as a sensitivity analysis.

Results

In total, 667 patients with a mean baseline eGFR of 27 ml/min per 1.73 m2 were included. Pulse wave velocity above the 95th percentile was observed in 124 (20%) patients at baseline. Absolute pulse wave velocity increased gradually over the median follow-up of 2.7 (interquartile range, 0.7–4.4) years, whereas pulse wave velocity z score remained relatively stable. Absolute pulse wave velocity over time associated with time; older age; higher mean arterial pressure, LDL cholesterol, and albuminuria; and lower ferritin. Pulse wave velocity z score (n=628) was associated with the same variables and additionally, with higher diastolic BP z score, lower height z score, younger age, and girls. Of 628 patients, 369 reached the composite end point of CKD progression (50% eGFR loss, eGFR <10 ml/min per 1.73 m2, or the start of KRT) during a median follow-up of 2.4 (interquartile range, 0.9–4.6) years. Pulse wave velocity z score did not associate with CKD progression by univariable or multivariable proportional hazard analysis correcting for the established predictors eGFR, proteinuria, and BP.

Conclusions

Pulse wave velocity is increased in children with CKD but does not associate with eGFR or CKD progression.
A Comparative Analysis of the Case Law of the European Court of Human Rights on the Right against Self-Incrimination
Authors: Escobar Veas Javier
Published: August 2022

The right against self-incrimination can be understood as the right of all persons to remain silent and not to be forced to collaborate with an investigation against them. Despite of its fundamental importance, the right against self-incrimination raises several theoretical and practical discussions. Can defendants refuse to produce documentary evidence? Does this right apply to administrative and civil proceedings? What degree of coercion is necessary to trigger the application of this right? This article aims to analyse the evolution and current state of the case law of the European Court of Human Rights in order to elucidate how the European court has resolved the questions posed above.
prisão administrativa de militares por indisciplina e sua (in)compatibilidade com o regime democrático
Authors: Cavalcante Leitão Santos Bruno , França Júnior Francisco de Assis de
Published: August 2022

O principal objetivo do presente artigo é diagnosticar e refletir criticamente sobre o descompasso da previsão constitucional da prisão administrativa de militares com as demais previsões da Constituição de 1988. Como problemática central tem-se o questionamento sobre se esse tipo de prisão, realizada por uma autoridade militar sem o crivo prévio do judiciário, seria compatível com o regime democrático? Como hipótese principal, apresenta-se o argumento de que não há compatibilidade entre esse tipo de prisão disciplinar e um regime democrático, assim como também não há relação de causalidade sustentável coerentemente entre essa ameaça de prisão e a manutenção da hierarquia e da disciplina militares, no que classificamos os argumentos de seus defensores como falaciosos. Por fim, para cumprir o objetivo proposto, utilizamos o método hipotético-dedutivo, em uma abordagem essencialmente qualitativa, bem como a técnica da revisão de literatura (doutrinária e legislativa), com referenciais teóricos entre as doutrinas constitucional, antropológica, criminológica e processual penal.
Confesiones y riesgos de condenas e imputaciones erróneas
Authors: Beltrán Román Víctor
Published: August 2022

La información disponible indica que e
l uso de confesiones falsas es uno de los factores que aumentaría el riesgo de producir condenas e imputaciones erróneas. Este artículo busca
servir como aproximación al problema en Chile mediante una revisión de sentencias de la Corte Suprema que se pronuncian sobre algunos aspectos de la declaración del imputado de conformidad con el artículo 91 del Código Procesal Penal chileno. El objetivo es obtener información de algunas prácticas policiales y criterios jurisprudenciales para luego, en base a los hallazgos, presentar algunas reflexiones insertas en el contexto del problema de las condenas e imputaciones erróneas.
El uso del neogótico en la modernidad arquitectónica mexicana. La microhistoria de dos iglesias como ejemplo
Authors: Checa Artasu Martín M.
Published: August 2022

A partir del análisis detallado de dos templos, la parroquia de Nuestra Señora del Refugio en Puerto Vallarta, Jalisco, y del templo de San Juan Bautista en Xicotepec de Juárez, Puebla, analizamos el proceso de construcción desde un punto social. En ambas iglesias se muestran elementos neogóticos insertados en construcciones próximas a los parámetros de la modernidad arquitectónica, los cuales son muestra de la continuidad del uso de este estilo formal hasta la actualidad.
La capilla del Seminario Mayor Palafoxiano de Puebla. Expresión arquitectónica-estructural del siglo XX
Authors: Barrera Sánchez Moisés , Mundo Hernández Julia Judith , Valerdi Nochebuena María Cristina
Published: August 2022

La disposición del espacio para la celebración litúrgica se traduce en la expresión formal que denota las ideas de los arquitectos o constructores. Este trabajo se ocupa de la capilla del Seminario Mayor Palafoxianode Puebla, que data de 1964 y que, en la actualidad, presta servicio mayormente a los seminaristas, aunque en ocasiones se lleve a cabo ahí alguna celebración de externos. El propósito es describir la relación de la solución geométrica y el diseño estructural con base en paraboloides hiperbólicos, materializada en cascarones de concreto armado, la cual es complementada con la expresión arquitectónica de los vitrales de Fernando Rodríguez Lago, como solución de espacios religiosos de los años sesenta del siglo XX. El estudio se soporta en la consulta documental acerca de los cascarones de concreto en diferentes latitudes, visitas de campo y entrevistas con involucrados en la materialización del Seminario Mayor Palafoxiano; el objetivo es mostrar el edificio como una manera de concebir los espacios religiosos en el siglo XX.
Las salas de conciertos. Catedrales para la música sinfónica
Authors: González Gottdiener Isaura
Published: August 2022

El presente artículo analiza la transformación de las salas de conciertos para la música sinfónica desde su aparición como tipología arquitectónica a finales del siglo XVII con la Sala de Música Holywell de Oxford (1748), hasta la concepción del espacio musical total de la filarmónica de Berlín (1963), y cómo esta última influyó de forma sustantiva en el proyecto de la Sala de Conciertos Nezahualcóyotl del Centro Cultural Universitario (CCU) de la Universidad Nacional Autónoma de México (UNAM). Además, se aborda cómo desde el surgimiento del nacionalismo la sociedad encontró en la literatura y en la música su mejor expresión cultural y las sacó de los salones de la alta aristocracia para formar parte de la vida de la naciente clase dominante: la burguesía. A la par, los cantantes y compositores se transformaron en verdaderos ídolos al igual que los pianistas. Con ello surgió otro tipo de peregrinación, en este caso cultural, dedicada al gozo de escuchar a prestigiosas orquestas al mando de excelsos directores en edificios emblemáticos: la música y la arquitectura como un binomio que mueve oleadas de gente tanto a los recintos físicos como a encender las transmisiones de los conciertos primero televisivas y ahora en internet.
El Templo Malatestiano y el libro I del De re aedificatoria de Leon Battista Alberti. El proceso de lineamenta: imitatio, tradición y novis inventis
Authors: Solís Rebolledo Patricia
Published: August 2022

El propósito de la investigación es profundizar en el estudio del Templo Malatestiano a partir de la teoría expresada en el libro I del De re aedificatoria de Leon Battista Alberti, cuestión que hasta el momento no ha sido discutida. La atención se centra en el proceso de diseño y el programa estético que comprende lineamenta, en particular en la analogía edificio-cuerpo y los principios regio, area, partitio, paries, tectum y apertio. Se propone que, en el Malatestiano, Alberti puso de manifiesto la intención de establecer entre el legado clásico y su presente una relación dialéctica, donde la composición de la obra arquitectónica es resultado de la tradición y de las novis inventis.
Safo, la musa y Andrómaca: desdoblamientos ambulatorios de Charles Baudelaire
Authors: Lavaniegos Solares Mircea
Published: August 2022

Este artículo aborda el motivo del caminar en Las flores del mal (1857) de Charles Baudelaire, haciendo alusión a algunos poemas del Spleen de París (1869), a través de tres temas-personajes o mitemas provenientes de la tradición grecolatina: Safo, la musa y Andrómaca. Se plantea que, en el desdoblamiento del poeta en estas tres figuras, la poética baudelairiana ofrece una tríada de caminares que le permiten plasmar su experiencia en un París que sufría cambios en su arquitectura, en su vida social y en su industria cultural. Estos desdoblamientos son los siguientes: el caminar erótico (Safo), el caminar mendicante (la musa) y el caminar alegórico (Andrómaca). Sirviéndose de las ideas de Walter Benjamin sobre el héroe como un elemento central del pensamiento mito-poético de Baudelaire, se pretende englobar estas expresiones como una manera de hacerle frente a una geografía urbana del siglo xix. Nos preguntamos por la relación de la poesía con el mito y en la capacidad de éste para dar sentido a una experiencia agobiada ante los cambios que la modernidad genera en la vida de sus habitantes. Desde un enfoque tematológico, se busca establecer puentes dentro de la obra baudelairiana que permitan comprender su producción como un todo coherente y articulado.
Y sin embargo, se mueven: la flâneuse como tema-personaje
Authors: Grandini Cynthia
Published: August 2022

En nuestros días, es frecuente conocer la práctica de artistas de variados contextos que describen su andar como un modo contemporáneo de flânerie en relación con la figura a la vez histórica y literaria del flâneur surgida en el siglo xix. A más de un siglo de distancia ha cobrado interés para las mujeres adoptar para sí el modo femenino flâneuse, dotando a este personaje de nuevos valores en relación con su propio género, tiempo y contexto. En el presente texto propongo que el devenir personaje y las sucesivas figuraciones y caracterizaciones del flâneur posibilitaron su permanencia en el imaginario artístico dando lugar a apropiaciones, variaciones e interpretaciones. En principio se señalarán algunas de las dificultades con las que nos encontramos al intentar definir al flâneur y se mencionarán ciertos debates en torno a la existencia, o no, de la flâneuse. Hacia el final del texto se abordarán un par de ejemplos de mujeres caminantes para reconocer cómo éstas retoman la tradición en la que está inserto el personaje y, a la vez, qué formas, problemas, temáticas y deseos introducen al proponerse hoy como flâneuses. Para este efecto serán clave desde el punto de vista metodológico los conceptos de tema-valor y tema-personaje como los ha trabajado Luz Aurora Pimentel, pues permitirán reconocer, por un lado, la traza del flâneur y, por otro, cómo se muestra en su tránsito hacia modalidades contemporáneas que incorporan debates sobre el género, la ciudad y sus protagonistas, habitantes y caminantes.
De París a La Habana
Authors: Pita González Alexandra
Published: August 2022

Entre 1940 y 1945 el Instituto Internacional de Cooperación Intelectual dejó de funcionar ante las vicisitudes de la Segunda Guerra Mundial. En esta situación, los países americanos se propusieron trasladar la sede de París a La Habana, donde se fundó el Centro Internacional, cuya operación nunca llegó a concretarse. Utilizando la correspondencia del intelectual y diplomático mexicano Alfonso Reyes, el artículo muestra los debates dentro del bloque latinoamericano entre quienes defendían una propuesta americana del instituto (independiente) y quienes se aferraban a la versión universalista (dependiente de la Sociedad de Naciones). El conocimiento de estos debates ayuda a entender cómo esta situación creada por la guerra reactivó el complejo equilibro entre América Latina, Europa y Estados Unidos.
Analog Driven Robot using IoT and Machine Learning
Authors: Pradhan Yash , Choudhary Sonali
Published: August 2022

Abstract: Visual impairment is one of the biggest limitations for humanity, especially in this day and age when information is communicated a lot by text messages (electronic and paper based) rather than voice. Facial recognition is category of biometric software that maps an individual’s facial features mathematically and stores the data as a sprint The software uses deep learning algorithms to compare a live capture or digital image to be stored face print in order to verify an individual’s identity vbnnn This project aims to develop a device to help people with visual impairment. In this project, we manufactured a device that converts an image’s text to speech. The basic outline is an embedded system that captures an image, extracts only the area of interest (i.e. region of the image that comprises text) and changes that text to speech. It is incorporated using a Raspberry Pi 3 and a Raspberry Pi camera module. We have two phases in our project that are Text to Speech and Facial Recognition. Every Module for picture handling and voice preparing are available in the device. It likewise can play and stop the output while reading. The expectation is that it has less error rate and less processing time and less cost productivity.
Investigation on Polypropylene Fiber Reinforced Concrete with Alccofine-1203
Authors: Chaitanya J. Sree Naga , Chandramouli Dr. K. , Kumar M. Chaitanya Nava , Kumar T. Swaroop
Published: August 2022

Abstract: In this study, cement containing Alccofine-1203, which is finer than cement and gives the concrete structure greater strength and endurance. Polypropylene fibers are used to enhance strength properties of concrete. Fibers made of polypropylene are added at rates of 0, 1.5, and 2.0%. Cement that has been mixed with several amounts of Alccofine-1203, including 5, 10, 7.5, and 12.5%. For concrete that has set, strength tests are performed after 28, 56 and 90 days. To evaluate the mechanical characteristics of concrete, destructive tests are performed on the dried specimens.
Investigation on Geopolymer Concrete by Using Different Mineral Admixtures
Authors: Chandramouli Dr. K. , Chaitanya J. Sree Naga , Nikhil Y. Prem , Rao T. Sambasiva
Published: August 2022

Abstract: The world is rapidly changing, and building construction is becoming increasingly important. If we look at it closely, the use of concrete increases, resulting in a scarcity of natural resources. To save our natural resources, replace some of the concrete proportions with the following methods. Using equal quantities of fly ash and metakaolin, fly ash and GGBS as admixtures in geopolymer concrete (50-50%). The results of the compressive strength split tensile strength, for 28, 56 and day strength tests. The combination of two admixtures and a super plasticizer allowed the strength parameters to be increased.