bluuebunny/crossref_metadata_2025 huggingface dataset:
Supervised breast cancer prediction using integrated dimensionality reduction convolutional neural network
Authors: Xu HuanQing , Shao Xian , Hui Shiji , Jin Li
Published: May 2023

Objectives

Breast cancer is a major health problem with high mortality rates. Early detection of breast cancer will promote treatment. A technology that determines whether a tumor is benign desirable. This article introduces a new method in which deep learning is used to classify breast cancer.

Methods

A new computer-aided detection (CAD) system is presented to classify benign and malignant masses in breast tumor cell samples. In the CAD system, (1) for the pathological data of unbalanced tumors, the training results are biased towards the side with the larger number of samples. This paper uses a Conditional Deep Convolution Generative Adversarial Network (CDCGAN) method to generate small samples by orientation data set to solve the imbalance problem of collected data. (2) For the high-dimensional data redundancy problem, this paper proposes an integrated dimension reduction convolutional neural network (IDRCNN) model, which solves the high-dimensional data dimension reduction problem of breast cancer and extracts effective features. The subsequent classifier found that by using the IDRCNN model proposed in this paper, the accuracy of the model was improved.

Results

Experimental results show that IDRCNN combined with the model of CDCGAN model has superior classification performance than existing methods, as revealed by sensitivity, area under the curve (AUC), ROC curve and accuracy, recall, sensitivity, specificity, precision,PPV,NPV and f-values analysis.

Conclusion

This paper proposes a Conditional Deep Convolution Generative Adversarial Network (CDCGAN) which can solve the imbalance problem of manually collected data by directionally generating small sample data sets. And an integrated dimension reduction convolutional neural network (IDRCNN) model, which solves the high-dimensional data dimension reduction problem of breast cancer and extracts effective features.
Development of immortalized rhesus macaque kidney cells supporting infection with a panel of viruses
Authors: Reiter Stefanie , Gärtner Sabine , Decker Katharina , Pöhlmann Stefan , Winkler Michael
Published: May 2023

Non-human primate (NHP)-based model systems faithfully reproduce various viral diseases including Ebola, influenza, AIDS and Zika. However, only a small number of NHP cell lines are available and generation of additional cell lines could help to refine these models. We immortalized rhesus macaque kidney cells by lentiviral transduction with a vector encoding telomerase reverse transcriptase (TERT) and report the generation of three TERT-immortalized cell lines derived from rhesus macaque kidney. Expression of the kidney podocyte marker podoplanin on these cells was demonstrated by flow cytometry. Quantitative real-time PCR (qRT-PCR) was employed to demonstrate induction of MX1 expression upon stimulation with interferon (IFN) or viral infection, suggesting a functional IFN system. Further, the cell lines were susceptible to entry driven by the glycoproteins of vesicular stomatitis virus, influenza A virus, Ebola virus, Nipah virus and Lassa virus as assessed by infection with retroviral pseudotypes. Finally, these cells supported growth of Zika virus and the primate simplexviruses Cercopithecine alphaherpesvirus 2 and Papiine alphaherpesvirus 2. In summary, we developed IFN-responsive rhesus macaque kidney cell lines that allowed entry driven by diverse viral glycoproteins and were permissive to infection with Zika virus and primate simplexviruses. These cell lines will be useful for efforts to analyze viral infections of the kidney in macaque models.
New discrete heavy tailed distributions as models for insurance data
Authors: Nadarajah Saralees , Lyu Jiahang
Published: May 2023

Although many data sets are discrete and heavy tailed (for example, number of claims and claim amounts if recorded as rounded values), not many discrete heavy tailed distributions are available in the literature. In this paper, we discuss thirteen known discrete heavy tailed distributions, propose nine new discrete heavy tailed distributions and give expressions for their probability mass functions, cumulative distribution functions, hazard rate functions, reversed hazard rate functions, means, variances, moment generating functions, entropies and quantile functions. Tail behaviour and a measure of asymmetry are used to compare the known and new discrete heavy tailed distributions. The better fits of the discrete heavy tailed distributions over their continuous counterparts as assessed by probability plots are illustrated using three data sets. Finally, a simulated study is performed to assess the finite sample performance of the maximum likelihood estimators used in the data application section.
Asia-Pacific stock market return and volatility in the uncertain world: Evidence from the nonlinear autoregressive distributed lag approach
Authors: Tran Minh Phuoc-Bao , Vo Duc Hong
Published: May 2023

This paper examines the effects of three distinct groups of uncertainties on market return and volatility in the Asia-Pacific countries, including (i) the country-specific and US geopolitical risks; (ii) the US economic policy uncertainty; and (iii) the US stock market volatility (using the VIX and SKEW indices). Our sample includes 11 Asia-Pacific countries for the 1985–2022 period. We employ the nonlinear autoregressive distributed lag approach (ARDL) estimation technique to capture the asymmetric effects of uncertainties on market return and volatility, which are documented in the literature. Some findings are documented as follows. First, we find that US uncertainty indices, including US geopolitical risk, US economic policy uncertainty, and US VIX, significantly impact Asia-Pacific stock markets, while the impacts of domestic geopolitical risk and the US skewness index (SKEW) are relatively weak. Second, Asia-Pacific stock markets tend to overreact to uncertainty shocks stemming from US economic policy uncertainty and US geopolitical risk. Third, US economic policy uncertainty has more significant effects than the US geopolitical risk. Finally, our research documents that Asia-Pacific stock markets react heterogeneously to good and bad news from US VIX. Specifically, an increase in US VIX (bad news) has a stronger impact than a decrease in US VIX (good news). Policy implications have emerged based on the findings of this study.
Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study
Authors: Sperstad Sigri Bakken , Sæther Julie Caroline , Klevjer Marie , Giskeødegård Guro Fanneløb , Bathen Tone Frost , Røsbjørgen Ragnhild , Dalen Håvard , Bye Anja
Published: May 2023

Background

Traditional biomarkers used to measure risk of myocardial infarction (MI) only explain a modest proportion of the incidence. Lipoprotein subfractions have the potential to improve risk prediction of MI.

Aim

We aimed to identify lipoprotein subfractions that were associated with imminent MI risk.

Methods

We identified apparently healthy participants with a predicted low 10-year risk of MI from The Trøndelag Health Survey 3 (HUNT3) that developed MI within 5 years after inclusion (cases, n = 50) and 100 matched controls. Lipoprotein subfractions were analyzed in serum by nuclear magnetic resonance spectroscopy at time of inclusion in HUNT3. Lipoprotein subfractions were compared between cases and controls in the full population (N = 150), and in subgroups of males (n = 90) and females (n = 60). In addition, a sub analysis was performed in participants that experienced MI within two years and their matched controls (n = 56).

Results

None of the lipoprotein subfractions were significantly associated with future MI when adjusting for multiple testing (p<0.002). At nominal significance level (p<0.05), the concentration of apolipoprotein A1 in the smallest high-density lipoprotein (HDL) subfractions was higher in cases compared to controls. Further, in sub analyses based on sex, male cases had lower lipid concentration within the large HDL subfractions and higher lipid concentration within the small HDL subfractions compared to male controls (p<0.05). No differences were found in lipoprotein subfractions between female cases and controls. In sub analysis of individuals suffering from MI within two years, triglycerides in low-density lipoprotein were higher among cases (p<0.05).

Conclusion

None of the investigated lipoprotein subfractions were associated with future MI after adjustment for multiple testing. However, our findings suggests that HDL subfractions may be of interest in relation to risk prediction for MI, especially in males. This need to be further investigated in future studies.
The impact of nutritional status in nivolumab-treated patients with advanced esophageal cancer
Authors: Takegawa Naoki , Hirabayashi Taku , Tanaka Shunta , Nishikawa Michiko , Tokuyama Nagahiro , Mimura Takuya , Kushida Saeko , Tsumura Hidetaka , Yamamoto Yoshinobu , Miki Ikuya , Tsuda Masahiro
Published: May 2023

Although phase III trials have reported improved overall survival in patients with advanced esophageal squamous cell carcinoma following treatment with nivolumab, as compared with chemotherapy (paclitaxel or docetaxel), the treatment was effective only in a limited number of patients. Therefore, the aim of this study is to determine whether there is a correlation between nutritional status (Glasgow prognostic score, prognostic nutritional index, and neutrophil-to-lymphocyte ratio) and prognosis of advanced esophageal cancer in patients treated with taxane or nivolumab therapy. The medical records of 35 patients who received taxane monotherapy (paclitaxel or docetaxel), for advanced esophageal cancer between October 2016 and November 2018 (taxane cohort) were reviewed. The clinical data of 37 patients who received nivolumab therapy between March 2020 and September 2021 (nivolumab cohort) were collected. The median overall survival was 9.1 months for the taxane cohort and 12.5 months for the nivolumab cohort. In the nivolumab cohort, patients with good nutritional status had significantly better median overall survival than those with poor nutritional status (18.1 vs. 7.6 months, respectively, p = 0.009, classified by prognostic nutritional index, 15.5 vs. 4.3 months, respectively, p = 0.012, classified by Glasgow prognostic score), whereas the prognosis of the patients treated with taxane therapy was less affected by the nutritional status. This suggests that the pretreatment nutritional status of patients with advanced esophageal cancer is a key factor for successful outcomes, especially for treatment with nivolumab.
Practical recommendations from a multi-perspective needs and challenges assessment of citizen science games
Authors: Miller Joshua Aaron , Vepřek Libuše Hannah , Deterding Sebastian , Cooper Seth
Published: May 2023

Citizen science games are an increasingly popular form of citizen science, in which volunteer participants engage in scientific research while playing a game. Their success depends on a diverse set of stakeholders working together–scientists, volunteers, and game developers. Yet the potential needs of these stakeholder groups and their possible tensions are poorly understood. To identify these needs and possible tensions, we conducted a qualitative data analysis of two years of ethnographic research and 57 interviews with stakeholders from 10 citizen science games, following a combination of grounded theory and reflexive thematic analysis. We identify individual stakeholder needs as well as important barriers to citizen science game success. These include the ambiguous allocation of developer roles, limited resources and funding dependencies, the need for a citizen science game community, and science–game tensions. We derive recommendations for addressing these barriers.
Prevalence, characteristics, consequences, and awareness of work-related musculoskeletal pain among cardiac sonographers compared with other healthcare workers in Saudi Arabia: A cross sectional study
Authors: Al Saikhan Lamia
Published: May 2023

Background

Evidence related to work-related musculoskeletal pain (WRMSP) among cardiac sonographers is incomplete. This study aimed to investigate the prevalence, characteristics, consequences, and awareness of WRMSP among cardiac sonographers compared with other healthcare workers in different healthcare settings in Saudi Arabia.

Methods

This was a descriptive, cross-sectional, survey-based study. An electronic self-administered survey using a modified version of the Nordic questionnaire was distributed to cardiac sonographers and control participants of other healthcare professions exposed to different occupational hazards. The χ2 test and logistic regression were performed to compare groups.

Results

In total, 308 participants completed the survey (mean age: 32.1±8.4; females: 207(68.1%)): 152(49.4%) sonographers and 156(50.6%) controls. WRMSP was more prevalent among cardiac sonographers than controls(84.8% vs 64.7%, p<0.0001), even after adjustment for age, sex, height, weight, BMI, education, years in current position, work-setting, and regular exercise(odds ratio [95% CI]: 3.0[1.54, 5.82], p = 0.001). Pain was more severe(p = 0.020) and lasted longer among cardiac sonographers(p = 0.050). The most affected body regions were the shoulders(63.2% vs 24.4%), hands(55.9% vs 18.6%), neck(51.3% vs 35.9), and elbows(23% vs 4.5%; p<0.01 for all). Pain in cardiac sonographers interfered with daily and social activities and interrupted their work-related activities(p<0.05 for all). More cardiac sonographers had plans to change profession(43.4% vs 15.8%; p<0.0001). A higher proportion of cardiac sonographers were aware of WRMSP(81% vs 77%) and its potential risks(70% vs 67%). However, cardiac sonographers infrequently utilised recommended preventative ergonomic measures for improving work practices, received insufficient ergonomics education and training on the risks and prevention of WRMSP, and had insufficient ergonomic work environment and support from employers.

Conclusions

WRMSP was more frequent and more severe in cardiac sonographers than in controls and adversely impacted their daily, social, and work-related activities, and future employment plans. Despite high awareness of WRMSP and its potential risks, cardiac sonographers infrequently utilised recommended preventative ergonomic measures and had insufficient ergonomic work environment and support from employers.
Influence of DNA characteristics on cell membrane damage stimulated by electrical short-circuiting via a low-conductive aqueous droplet in dielectric oil
Authors: Tsurusaki Yoshino , Watanabe Yuki , Numano Rika , Shibata Takayuki , Kurita Hirofumi
Published: May 2023

We investigated gene electrotransfer using electrical short-circuiting via a cell suspension droplet in dielectric oil. An aqueous droplet of a few microliters placed between a pair of electrodes can be deformed by an intense DC electric field depending on the electric field intensity. When a droplet containing suspended cells and plasmid DNA elongates during deformation and connects the electrodes, the resulting short circuit can cause successful gene electrotransfection into various mammalian cells. We also investigated the influence of the electroporation medium on membrane permeabilization and the mechanisms of gene electrotransfection using short-circuiting via an aqueous droplet. One aim of this study was to investigate the influence of the conductivity of electroporation medium on gene electrotransfer stimulated by short-circuiting. It was found that low-conductivity medium with plasmid DNA resulted in a significant decrease in cell viability compared to the high-conductivity medium with plasmid DNA. Therefore, we demonstrated the influence of exogenous DNA on membrane damage stimulated by droplet electroporation using a low-conductivity medium. Thus, electrical stimulation with the combination of plasmid DNA and the low-conductivity medium resulted in tremendous membrane damage. Linearized plasmid DNA stimulated more significant membrane damage than circular DNA. However, the size of linear DNA did not influence the efflux of small intracellular molecules.
Long non-coding RNAs are essential for Schistosoma mansoni pairing-dependent adult worm homeostasis and fertility
Authors: Silveira Gilbert O. , Coelho Helena S. , Pereira Adriana S. A. , Miyasato Patrícia A. , Santos Daisy W. , Maciel Lucas F. , Olberg Giovanna G. G. , Tahira Ana C. , Nakano Eliana , Oliveira Maria Leonor S. , Amaral Murilo S. , Verjovski-Almeida Sergio
Published: May 2023

The trematode parasite Schistosoma mansoni causes schistosomiasis, which affects over 200 million people worldwide. Schistosomes are dioecious, with egg laying depending on the females’ obligatory pairing with males. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides with low or no protein-coding potential that have been involved in other species with reproduction, stem cell maintenance, and drug resistance. In S. mansoni, we recently showed that the knockdown of one lncRNA affects the pairing status of these parasites. Here, we re-analyzed public RNA-Seq data from paired and unpaired adult male and female worms and their gonads, obtained from mixed-sex or single-sex cercariae infections, and found thousands of differentially expressed pairing-dependent lncRNAs among the 23 biological samples that were compared. The expression levels of selected lncRNAs were validated by RT-qPCR using an in vitro unpairing model. In addition, the in vitro silencing of three selected lncRNAs showed that knockdown of these pairing-dependent lncRNAs reduced cell proliferation in adult worms and their gonads, and are essential for female vitellaria maintenance, reproduction, and/or egg development. Remarkably, in vivo silencing of each of the three selected lncRNAs significantly reduced worm burden in infected mice by 26 to 35%. Whole mount in situ hybridization experiments showed that these pairing-dependent lncRNAs are expressed in reproductive tissues. These results show that lncRNAs are key components intervening in S. mansoni adult worm homeostasis, which affects pairing status and survival in the mammalian host, thus presenting great potential as new therapeutic target candidates.
Aal-circRNA-407 regulates ovarian development of Aedes albopictus, a major arbovirus vector, via the miR-9a-5p/Foxl axis
Authors: Gao Yonghui , Yang Lu , Chen Yulan , Liu Peiwen , Zhou Ying , Chen Xiaoguang , Gu Jinbao
Published: May 2023

Aedes albopictus shows a rapid global expansion and dramatic vectorial capacity for various arboviruses, thus posing a severe threat to global health. Although many noncoding RNAs have been confirmed to play functional roles in various biological processes in Ae. albopictus, the roles of circRNA remain a mystery. In the present study, we first performed high-throughput circRNA sequencing in Ae. albopictus. Then, we identified a cysteine desulfurase (CsdA) superfamily gene-originated circRNA, named aal-circRNA-407, which was the third most abundant circRNA in adult females and displayed a fat body highly expressed manifestation and blood feeding-dependent onset. SiRNA-mediated knockdown of circRNA-407 resulted in a decrease in the number of developing follicles and a reduction in follicle size post blood meal. Furthermore, we demonstrated that circRNA-407 can act as a sponge of aal-miR-9a-5p to promote the expression of its target gene Foxl and eventually regulate ovarian development. Our study is the first to report a functional circRNA in mosquitoes, expanding our current understanding of important biological roles in mosquitoes and providing an alternative genetic strategy for mosquito control.
Corps, culture et société: une lecture de L’enfant de sable et La nuit sacrée de Tahar Ben Jelloun
Authors: Hamdani Idris
Published: May 2023

This article aims to study the vision of Tahar Ben Jelloun towards the body through which the social and cultural situation of the Maghreb countries is clarified. The Moroccan author charges the body with the Arab-Muslim tradition, with male domination and culture, with the erasure of women in society. Hadj Ahmed Souleïmane, in a country that favours men, after having had seven daughters, he feels dishonoured, castrated, finally to repair this evil and rehabilitate his honour, he makes his daughter a boy, from birth, who will be the man of the family, his heir, not only of material goods but essentially of the values of masculinity and patriarchy. He manipulates both his daughter’s body and her way of thinking, teaching her how to become a man according to tradition, also inspecting her body, her reactions and her actions. The body is thus polysemous, through which we understand Ben Jelloun’s vision of gender, culture, family education, society, the male/female relationship and religion. Ben Jelloun uses the body for subversive reasons in order to deconstruct society’s vision of the body, of the values and culture that determine society. In his work, the body thus consists in condemning and denouncing.
Tras la diferencia entre argumentación y explicación
Authors: Gascón José Ángel
Published: May 2023

Los argumentos y las explicaciones son dos tipos de discurso que no siempre han sido distinguidos cabalmente. En la actualidad, tanto en la pedagogía de la ciencia como en los estudios de la argumentación, se ha insistido en la necesidad de diferenciarlos para captar adecuadamente la naturaleza de las explicaciones y los argumentos. Es en la teoría de la argumentación donde más explícitamente se han propuesto criterios de demarcación entre ambos. Sin embargo, aquí argumentaré que los criterios que habitualmente se usan en la teoría de la argumentación para distinguir entre un argumento y una explicación (lo que llamo la “distinción estándar”) adolecen de varios problemas. Por un lado, en varios casos relevantes los criterios no proporcionan ninguna orientación o arrojan resultados cuestionables. Por otro lado, los criterios de distinción se han limitado al ámbito de la argumentación teórica y han ignorado las particularidades del ámbito práctico.
Patrimonio cultural en las representaciones sociales de profesores de música en contextos latinoamericanos
Authors: Veber Andréia , Raimundo Yaegashi Solange Franci , Sánchez-Macías Inmaculada
Published: May 2023

El estudio presenta un análisis de las representaciones sociales del profesorado de música sobre patrimonio cultural. Se diseña una investigación de corte mixto, con evidencias recogidas a través de entrevistas semiestructuradas y el test de asociación libre de palabras. Como resultados destacamos que las representaciones sociales de estos docentes conforman una estructura compleja, con su centralidad en las identidades, asociadas a diferentes factores periféricos que, interconectados, se consolidan como pensamiento social sobre los temas investigados.
Plataforma de Integração de Componentes para Sistemas Embarcados em Aplicações Espaciais
Authors: Natham Domingos Carlos , Almeida dos Santos Douglas , Grignani Wesley , Rossi de Melo Douglas
Published: May 2023

ABSTRACTArtificial satellite systems launched into space are designed forvarious activities, such as communication, space observation, andremote sensing. These satellites have consisted of a growing numberof modules to perform a wide variety of tasks. Due to the limitationsof onboard processors, there is an increasing need for structures thatsupport the functions performed by the satellites. One approachis to use specific purpose processors to accelerate these functions.However, integrating accelerators with processors is a complexactivity. Considering this,we propose the development of a platformthat seeks to facilitate the creation of Systems-on-Chip withhardware and software components for use in space applications.
empirical study of air transport demand forecast in Nigeria
Authors: Reuben Nwaogbe Obioma , Monday Adebayo , Wokili-Yakubu Huwa
Published: May 2023

The aim of the study is to estimate the air travel demand forecast of domestic passengers’ travels in Nigeria from 2002-2016. Data wesourced from Central Bank of Nigeria, National Bureau of Statistics, and Federal Airport Authority of Nigeria. The study utilized multiple regressions model using Stata-Graphic software solver to analyze the data. From the analysis, the result shows that there is significant relationship between the explanatory variable (passengers) and unexplanatory variables National Disposable Income, Population, Average Airfare, Gross Domestic Product, Exchange Rate, Total Expenditure, and Crude oil price, accounted for adjusted R of 93.624% relationship with demand for domestic air travel of passenger. The R-square statistic shows that the fitted model explains the variability in Number of passenger (NPAX) which is 96.8124%.  The Hypothesis testing reveals that National Disposable Income and Air fare have strong statistically significant relationship with the demand for domestic air travel with P-value of 0.0013. Moreso, there is statistically significant relationship for National Disposable Income, Average Airfare, and Crude oil price with P-value of 0.0017 and 0.0445 respectively. Furthermore, forecast of the number of passengers and average airfare was carried out using ARIMA (1,0,0) model which made available the future predicted values for the number of passenger movement and average airfare for the next 10-12 years to come.  Thus, the study recommends that stakeholders in the air transport sector should work towards improving the capacity and infrastructure to accommodate the growth of air travel demand for domestic air travel in Nigeria. Policy implications were made on how to regulate the sector by having a good pricing policy to control the air fare for the industry.
O uso da sequência didática no ensino de Física: A inserção dos estudantes da Escola Estadual Tabelião Júlio Maria, Touros-RN
Authors: Silva José Jefferson da , Medeiros Geneci Cavalcanti Moura de
Published: May 2023

O referido texto trata-se das potencialidades das atividades laboratoriais para o ensino de física e das principais características para o ambiente educacional, promovendo uma aprendizagem diferenciada para estudantes do ensino médio, contemplando assim conteúdos de hidrostática. O referido artigo possui como objetivo geral sugerir e aplicar uma unidade didática para estudantes da primeira série do ensino médio da Escola Estadual Tabelião Júlio Maria, localizada no município de Touros, Rio Grande do Norte. São Propostas nesta Unidade didática cinco atividades laboratoriais utilizando-se materiais de fácil acesso, desta forma almeja-se verificar qual a contribuição que esta abordagem proporciona no processo de ensino aprendizagem no conteúdo de hidrostática, promover o trabalho em equipe e o espirito crítico com relação ao papel da física, além de identificar as potencialidades das atividades laboratoriais para os conteúdos previstos. Pensando na temática que envolve o estudo da hidrostática, a unidade didática é constituída de cinco atividades sendo elas: Ensinando o conceito de flutuação dos corpos na água, verificando o conceito de densidade e pressão através das atividades laboratoriais, A vela que levanta água e a garrafa chuveirinho. Nesse sentido, a física em consonância com as atividades laboratoriais com materiais de fácil acesso deixa de ser meramente abstrata e ganha requisitos práticos, pois o estudante está em contato real com os conceitos trabalhados na disciplina, sendo assim relacionado com o dia a dia dos estudantes imersos nas atividades propositivas. Ao termino do trabalho de pesquisa, espera-se que esse material possa servir além da aplicação do conhecimento para os estudantes, o estimulo para professores estudantes de física, já que as atividades aqui propostas objetivam trabalhar alguns conceitos abstratos, sendo primordial para o contexto da formação de professores, formalizando principalmente o desenvolvimento do saber de todos os envolvidos nesse contexto educacional.
Multiple Acyl-CoA Dehydrogenase Deficiency: A Rare Cause of Hepatomegaly
Authors: Nana Sede Mbakop Raissa , Forlemu Arnold Nongmoh , Manatsathit Wuttiporn
Published: May 2023

Multiple Acyl-CoA dehydrogenase deficiency (MADD) is an autosomal recessive disorder that can manifest with hepatic and muscular dysfunction. MADD can be fatal in neonates; however, late-onset MADD has a milder course and often becomes symptomatic during adulthood. A 20-year-old patient presented to the hepatology clinic with elevated liver enzymes and hepatomegaly. Several investigations including a liver biopsy were unremarkable. Subsequently, the patient developed rhabdomyolysis and nonketotic hypoglycemia raising suspicion for mitochondrial disorders. Plasma acylcarnitine levels performed showed elevated C4-C18:2 consistent with MADD. Although the patient denied a complete genetic evaluation, the patient had complete resolution of symptoms after riboflavin and diet modification.
Bad Connection: Stent-to-Stent Fistulization After Common Bile Duct and Transjugular Intrahepatic Portosystemic Shunt Stenting
Authors: Issac Aaron G. , Youngblood Alix , Enunwa Chidi , Veeramachaneni Hima , Khare Anshika , Razvi Mohammad , Levert Francis Edward
Published: May 2023

A 29-year-old man with chronic portal venous thrombosis resulting in portal biliopathy required stenting of his common bile duct (CBD) and underwent a transjugular intrahepatic portosystemic shunt (TIPS) procedure to decrease portal pressures. He later presented with abdominal pain in the setting of prolonged CBD stent placement and was found to have air within his TIPS stent with a fistula on endoscopic retrograde cholangiopancreatography between his fully covered CBD stent and bare metal TIPS stent. There was concern that further intervention would lead to an air embolus. We suggest that when multiple stents are indicated, stent selection with close monitoring is critical.
Afferent Loop Syndrome as Second Presentation of Gastric Outlet Obstruction in Patient With Billroth II Anatomy
Authors: Davis Brenton G. , Bayudan Alexis M. , Kouanda Abdul M.
Published: May 2023

Afferent loop syndrome can result from both benign and malignant strictures of the biliary limbs of patients with surgically altered anatomy. Afflicted patients accumulate intestinal and pancreaticobiliary secretions, which leads to bowel distention and pain. We describe the endoscopic management of a 52-year-old woman with a history of Billroth II gastrojejunostomy due to gastric cancer who developed malignant gastric outlet obstruction and subsequently malignant afferent loop syndrome, using lumen-apposing metal stents.
Investigation of the Relationship Between the Interpersonal Problem-Solving Skills and Self-Determination Levels of Pre-Service Teachers who Received and did not Receive Art Training
Authors: EREZ Aşkın Ceren , TASKESEN Orhan
Published: May 2023

This research aimed to investigate the relationship between the problem-solving skills and assertiveness levels of students, who received and did not receive art education in faculty of education, and whether these two variables differ according to the gender, grade differences, and attended school. The study group included the education departments of Erzincan Binali Yıldırım University, Faculty of Education in 2018-2019. The purposeful sampling method was used in this research which was conducted to reveal the relationship between the problem-solving skills and assertiveness levels of students who received and did not receive art education in faculty of education, and whether these two variables differ according to the gender, grade differences, and attended school, is suitable to the relational survey model. As a result of the research, it was found that there was significant difference regarding the gender and grade variable. However, it was realized that there was a significant difference in the interpersonal problem-solving scores between some departments.
The Study of Primary School Visual Arts and Science Curricula in Turkey in the Context of Interdisciplinary Approaches: 1923-2020
Authors: KAYALIOĞLU Sevgi , TUNÇ Tuncay
Published: May 2023

This study aims to identify any associated subjects in the primary school Visual Arts and Science courses in Turkey from 1923 when the Republic was declared to 2020, and reveal the historical dimension of such associations between the two courses. Primary school curricula of 1924, 1926, 1936, 1948, 1968, and 1992; 2005 Science and Technology and 2006 Visual Arts course curricula; 2013 and 2018 primary school curricula have been reviewed. The data were evaluated by content analysis in the research carried out by the document review method. At the end of the research, it is recognized that the association between the two courses has been made since the 1924 Curriculum, the first program of the Republic although it was disrupted in certain periods. In addition, it has been found that in the interdisciplinary approach adopted between 1926 and 1992, the Art-Craft course was primarily seen as the field of application of the Science courses and assumed a role of an auxiliary course in teaching the Science courses and that despite the increase in the number of learning outcomes in the current programs, the learning outcomes to be associated with the two courses are still quite limited.
Efficacy Beliefs and Metacognitive Awareness in English Language Teaching and Teacher Education
Authors: ÜSTÜNBAŞ Ümran , ALAGÖZLÜ Nuray
Published: May 2023

Teacher self-efficacy and metacognitive awareness could be regarded as significant in teaching and teacher education due to psychological and cognitive aspects of them which are directly linked to quality of teaching since 21st century skills which involve elaborate use of cognitive skills also necessitate teachers having those skills as well, which is part of metacognitive awareness. Thus, this paper presents findings of a mixed-method study that has been conducted with pre-service (N=97) and in-service (N=53) English language teachers on their perceived levels of teacher self-efficacy and metacognitive awareness and aimed to explore any similarities or differences between the two groups in the two variables taking into account that a comparison could reveal further issues to consider such as factor leading to them. For this purpose, teacher self-efficacy scale developed and validated by the researchers and Metacognitive Awareness Inventory (Schraw & Dennison, 1994) were administered to the participants and followed by semi-structured interviews focusing on in-depth analyses of quantitative data. The findings indicated that in-service teachers had higher levels of metacognitive awareness than pre-service teachers whereas levels of their teacher self-efficacy were not significantly different. Qualitative data, on the other hand, suggested a number of factors leading to that difference.
Perceived Organizational Barriers of Female Education Administrators About Their Career Progression in Turkish Republic of Northern Cyprus
Authors: DEBEŞ Gülyüz , TATAR Ali , ABACILAR Mehmet
Published: May 2023

The study seeks to investigate the perceived organizational barriers on women career progression in Turkish Republic of Northern Cyprus (TRNC). A descriptive survey was carried out in an attempt to examine the barriers that female face in educational organizations when trying to empower their careers. The sample of the study were composed 21 women who were selected randomly. The data were collected using quantitative research model. Descriptive statistics and analysis of variance were used to explain the results. The results revealed that the female education administrators career advancement was not affected by biological make up of female in family live % 57.14 (N=12) and female education administrators perceived their career progression to be not affected by male dominated hierarchies in the workplace %71.43 (N=15). In addition, the biological make up of women was not block from any promotions while female moving up the senior positions in the workplace %76.19 (N= 16). However, the results revealed that female education administrators face with career barriers during their career advancement % 76.19 (N=16). The results revealed that female education administrators overcame challenges in their career progression while they persisted in gender equality, empathy, patience, responsible decision making, collaboration and Corporation with men and seeking legal right in the workplace. In addition, the participants stated that there was no prejudice about female biological make up against of female career progressions in the educational organizational settings of TRNC %66.67 (N=14). However, female education administrators need organizational support in TRNC. They should confront the challenge and responsibility of identifying work-live balance requirements which should provide adequate opportunities with male education administrators.
Correctional Education in Turkey: An Historical Overview from Past to Present and Evaluation of Current Practices
Authors: AKIN Gulden
Published: May 2023

Prison education is covered within the scope of adult education for the reasons such as content, program, and target group. Incarcerated people, on the other hand, are one of the disadvantaged groups among adult learners that have been increasingly studied in recent years. The present research aims to analyze the current correctional education in Turkey with reference to practices in the past and to discuss the challenges in the implementation process through descriptive analysis. According to the results of the paper, the number of inmates who participate in the first and second-degree courses is fewer than the total population of illiterate prisoners and literate prisoners who have no primary school diploma. Moreover, the study reveals that it is an exemplary activity that the prisoners acquire a profession with vocational training while they are employed within the correctional settings. However, they have difficulty finding jobs after they are released. In addition, according to the findings of the study, prisoners are generally satisfied with the religious education activities going on inside the prisons. Nevertheless, there is a need to regulate the prison population in Turkey in order to make the inmates equally benefit from the educational, cultural, and recreational activities. Finally, it is significant to disseminate technology-enriched education programs to eliminate the challenges that arise in the implementation of educational activities particularly after the COVID-19 pandemic.
PERAN UNODC DALAM MEMBERANTAS PERDAGANGAN NARKOTIKA GLOBAL YANG MELALUI AKSES LAUT
Authors: Ichwani Alfirza Dafrin Achmad , Rebala Lazarus Tri Setyawanta , Farida Elfia
Published: May 2023

Salah satu wujud dari kejahatan transnasional terorganisir yang mengancam stabilitas keamanan dunia adalah perdagangan narkotika global. Pandemi COVID-19 beberapa tahun ini juga telah membuat sindikat perdagangan narkotika global beradaptasi dengan adanya pembatasan perjalanan dan penutupan perbatasan darat dan udara. Akibatnya, terjadi peningkatan penggunaan rute laut dalam perdagangan narkotika global. Semua negara bergantung pada keamanan laut, oleh sebab itu dalam mengatasi perdagangan narkotika global yang melalui akses laut diperlukan pendekatan lintas negara. Dalam penelitian ini permasalahan diuraikan lebih lanjut menggunakan pendekatan yuridis-normatif, dengan spesifikasi penelitian deskriptif. UNODC sebagai salah satu kantor PBB yang memiliki misi untuk berkontribusi membuat dunia lebih aman dari kejahatan, khususnya dalam hal ini perdagangan narkotika global yang melaui akses laut beserta dengan negara-negara anggota berkomitmen untuk memberantas perdagangan narkotika global melalui akses laut dengan berbagai program dan kerjasama seperti The Global Maritime Crime Programme (GMCP), Program Governance Committee, serta berbagai macam program lainnya termasuk kampanye dan pelatihan.
EKSISTENSI HUKUM ADAT MASYARAKAT SUKU SAKAI DALAM PELAKSANAAN HAK ULAYAT DI PROVINSI RIAU
Authors: Rizki M. Fathur , Prasetyo Agung Basuki , Triyono Triyono
Published: May 2023

Masyarakat hukum adat Suku Sakai di Kabupaten Bengkalis Provinsi Riau merupakan salah satu masyarakat hukum adat yang masih memiliki wilayah tanah ulayat dalam pemanfaatannya memperhatikan ketentuan hukum adat yang berlaku. Akan tetapi hak ulayat yang dimiliki Suku Sakai semakin lama semakin melemah. Hal ini disebabkan oleh  pengambilalihan dan penguasaan oleh pihak investor. Akibatnya luas tanah ulayat yang dimiliki oleh suku sakai semakin lama semakin mengalami penurunan. Pengambilalihan tanah ulayat yang dilakukan oleh pihak investor menyebabkan masyarakat Suku Sakai sulit dalam memanfatkan tanah dan hutan yang mereka miliki. Berdasarkan hal tersebut menimbulkan perkembangan ekonomi masyarakat Suku Sakai melemah dalam memenuhi kebutuhan hidup mereka sehari-hari. Oleh karena itu penelitian ini bertujuan untuk mengetahui bagaimana pengakuan dan perlindungan terhadap eksistensi hak ulayat masyarakat Suku Sakai.
PERLINDUNGAN HUKUM DALAM PEMBELIAN RUMAH DAN BANGUNGAN MELALUI OPER KREDIT PERUMAHAN (STUDI PUTUSAN NOMOR: 27/PDT.G/2017/PN.UNR)
Authors: Prakoso Prajna Enggar , Silviana Ana , Triyono Triyono
Published: May 2023

Peralihan hak atas tanah yang dilakukan secara oper kredit terhadap objek yang masih dibebani hak tanggungan haruslah memenuhi syarat jual beli dengan berdasar pada syarat formil maupun materiil. Akan tetapi pada praktek masyarakat masih terdapat jual beli yang dilakukan tanpa melibatkan PPAT atau disebut dengan jual beli di bawah tangan, sehingga terjadi sengketa tanah kedepanya seperti dalam contoh Kasus Putusan Pengadilan Nomor 27/Pdt.G/2017/PN. Unr. Tujuan penilitian ini adalah untuk mengetahui pertimbangan hakim dalam memutus Kasus Perdata No.27/Pdt.G/2017/PN. Unr dan mengetahui perlindungan hukum bagi pembeli tanah dan bangunan pada perumahan dalam Putusan Pengadilan Negeri No.27/Pdt.G/2017/PN. Unr. Metode pendekatan pada penilitian ini menggunakan metode yuridis normatif. Berdasarkan hasil penelitian pertimbangan hakim memutuskan jual beli yang dilakukan pada Kasus Putusan Pengadilan Nomor 27/Pdt.G/2017/PN. Unr adalah sah dan menyatakan pembeli mempunyai itikad baik yang harus dilindungi hukum sesuai peraturan perundang-undangan yang berlaku.
IMPLEMENTASI PROGRAM PENDAFTARAN TANAH SISTEMATIS LENGKAP DI KABUPATEN KENDAL
Authors: Hastuty Deppika Rindu , Silviana Ana , Adhim Nur
Published: May 2023

Pelaksanaan PTSL di Kabupaten Kendal masih terdapat beberapa kendala yang menghambat pelaksanaan program PTSL oleh Kantor Pertanahan Kabupaten Kendal. Untuk mengetahui pelaksanaan program yang ada di Kabupaten Kendal dilakukan penelitian mengenai implementasi program PTSL di Kabupaten Kendal. Penelitian ini bertujuan untuk mengetahui implementasi program PTSL di Kabupaten Kendal, serta apa saja yang menjadi faktor penghambat PTSL yang terjadi di Kabupaten Kendal. Metode pendekatan yang akan digunakan penulis dalam penulisan hukum ini adalah yuridis empiris. Spesifikasi penelitian yang akan digunakan penulis dalam penulisan hukum ini adalah deskriptif analitis, berikutnya dianalisa dengan metode analisis data yang diperlukan dalam penelitian ini adalah metode analisis kualitatif yaitu data yang diperoleh. Hasil penelitian yang diperoleh tentang implementasi program Pendaftaran Tanah Sistematis Lengkap di Kabupaten Kendal yaitu masih terhambat dikarenakan kurangnya sumber daya manusia dan juga masih adanya sengketa. Hal ini dapat dilihat dari Desa Kalibareng Kecamatan Patean yang masih terdapat sengketa tanah, sedangkan di Desa Sidomakmur Kecamatan Kaliwungu Selatan sudah berjalan dengan lancar. Kesimpulan dari penelitian ini adalah implementasi program PTSL di Kabupaten Kendal belum memenuhi target, dikarenakan masih adanya faktor faktor yang menghambat pelaksanaan program PTSL di Kabupaten Kendal.
PERTANGGUNGJAWABAN PEJABAT PEMERINTAH TERHADAP PERBUATAN MELAWAN HUKUM YANG MENIMBULKAN KERUGIAN KEUANGAN NEGARA (STUDI KASUS PUTUSAN PENGADILAN NEGERI MEDAN NOMOR: 75 /PID.SUS/TPK/2016/PN.MDN.)
Authors: Tarigan Liliana Christina , Juliani Henny , Adiyanta F. C. Susila
Published: May 2023

Pejabat Pemerintah yang melakukan perbuatan melawan hukum sering menimbulkan kerugian dalam keuangan negara. Penelitian ini bertujuan untuk mengetahui paramater perbuatan melawan hukum dan bentuk pertanggungjawaban pejabat pemerintah atas perbuatan melawan hukum sehingga mengakibatkan kerugian keuangan negara. Metode penelitian yang digunakan adalah yuridis normatif, dengan pendekatan perundang – undangan (statute approach) dan pendekatan kasus (case approach). Hasil penelitian menunjukkan parameter perbuatan melawan hukum berdasarkan Undang – Undang, terbukti menambahkan lembaga penerima bantuan hibah dan bansos yang tidak sesuai dengan ketentuan dalam laporan, serta menyetujui rekomendasi yang diusulkan oleh Eddy Syofian selaku Kepala SKPD Kesbangpol dan Linmas yang mengakibatkan sejumlah penyimpangan dalam penyaluran dan penggunaan dana bantuan hibah dan bantuan sosial. Bentuk pertanggungjawaban yang dilakukan adalah dijatuhi pidana penjara selama 6 (enam) tahun dan denda dengan ketentuan jika denda tidak dibayar harus diganti dengan pidana kurungan selama 4 (empat) bulan dan pembebanan biaya perkara.
PELAKSANAAN REHABILITASI BIDANG KEPEGAWAIAN DALAM PUTUSAN PERADILAN TATA USAHA NEGARA (STUDI KASUS: PUTUSAN NOMOR: 042/G/2015/PTUN.SMG JUNCTO NOMOR 100/B/2016/PT.TUN.SBY)
Authors: Hidayat Taufik , Utama Yos Johan , Leonard Lapon Tukan
Published: May 2023

Seringkali eksekusi putusan peradilan tata usaha negara tidak dilaksanakan disebabkan beragam faktor yang mempengaruhinya salah satunya ialah law awareness pejabat pemerintahan yang kurang sehingga dengan melihat pelaksanaan eksekusi putusan yang mengandung pemberian rehabilitasi terlihat akan lebih sulit karena menyangkut pengembalian hak penggugat dalam hal kedudukan, harkat dan martabatnya sebagai pegawai. Metode yang digunakan adalah yuridis empiris dengan menggunakan jenis data primer dan sekunder, spesifikasi penelitian bersifat studi kasus dengan metode analisis data ialah deksriptif kualitatif. Permasalahan yang diteliti adalah skema pelaksanaan rehabilitasi dari putusan nomor: 042/G/2015/PTUN.SMG juncto nomor 100/B/2016/PT.TUN.SBY dibanding dengan skema menurut undang-undang peradilan tata usaha negara dan problematika pelaksanaan realisasinya. Hasil penelitian menunjukan pelaksanaan rehabilitasi terlaksana akan tetapi tidak sepenuhnya sesuai dengan aturan hukum peradilan tata usaha negara karena ada force majeure pergantian Wali Kota dari definitif kepada pelaksana tugas. Problematika yang dihadapi seperti ketidaktelitian PTUN dalam mengirimkan putusan inkracht hingga tidak adanya mekanisme rehabilitasi harkat dan martabat.
LELAH TAPI BERKAH: INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS PENGALAMAN PENGASUHAN PADA IBU YANG MEMILIKI ANAK KEMBAR BEDA JENIS KELAMIN
Authors: Izzah Lailatul , Indrawati Endang Sri
Published: May 2023

Pengasuhan merupakan salah satu proses pembentukan karakter pada anak. Tujuan dari penelitian ini adalah untuk memahami pengalaman pengasuhan anak kembar beda jenis kelamin. Penelitian ini melibatkan tiga partisipan dan menggunakan metode purposive dengan kriteria yaitu pelaku pengasuhan, memiliki anak kembar beda jenis kelamin, dan usia anak 6-12 tahun. Pengumpulan data menggunakan teknik in-depth interview dan dianalisis dengan metode Interpretative Phenomenological Analysis. Penelitian ini memperoleh tiga tema induk, yaitu : (1) pengalaman pengasuhan anak kembar beda jenis kelamin, yang terdiri dari pengasuhan ganda, dan dukungan keluarga, hambatan pengasuhan dan tantangan pengasuhan; (2) makna pengasuhan terdiri dari kebersyukuran, pembelajaran dan perjuangan; (3) harapan pengasuhan yang terdiri dari terbentuknya karakter anak dan dukungan masa depan. Partisipan L merasa lelah dalam mengasuh anak kembar, namun tetap merasa bersyukur karena diberikan anak kembar beda jenis kelamin. Partisipan M merasa anak kembarnya cukup menjadi beban secara finansial namun kehadiran anak kembarnya dianggap sebagai anugerah karena diberikan anak lakilaki dan perempuan dalam satu waktu. Sedangkan partisipan A merasa anak kembar merupakan sesuatu yang patut disyukuri karena tidak semua orang merasakannya.