bluuebunny/crossref_metadata_2025 huggingface dataset:
Validation and cross-cultural adaptation of the Korean translation of the Achilles tendon Total Rupture Score
Authors: Park Young Hwan , Cho Hyun Woo , Choi Jung Woo , Kim Hak Jun
Published: October 2021

Background

The Achilles tendon Total Rupture Score (ATRS) is a widely used patient-reported outcome measure to assess clinical outcomes of Achilles tendon rupture, but it has not been validated in Korean yet. The purpose of this study was to translate the ATRS into Korean and evaluate its reliability and validity in a Korean population.

Methods

The ATRS was translated into Korean according to recommended guidelines for forward-backward translation. Thirty-eight patients who underwent surgical treatment for Achilles tendon rupture from 2017 to 2019 were enrolled. Reliability was evaluated by the intraclass correlation coefficient (ICC), standard error of measurement (SEM), and minimal detectable change (MDC). Construct validity was assessed with Spearman rank correlations with the Korean version of the Foot and Ankle Outcome Score (FAOS) and Numeric Rating Scale (NRS) for pain in daily activity.

Results

The Korean translation of the ATRS had excellent test-retest reliability (ICC = 0.84) and acceptable internal consistency (Cronbach’s alpha = 0.84). The SEM was 6.61, and the MDC was 18.32 at the individual level and 2.97 at the group level. The Korean translation of the ATRS was strongly correlated with the FASO (r = 0.88). Correlation with the NRS in daily activity (r = − 0.66) was moderate.

Conclusion

The Korean translation of the ATRS showed sufficient reliability and validity for use in the Korean population.

Level of evidence

II.
Nurses’ experiences during the COVID-19 pandemic in Iran: a qualitative study
Authors: Zamanzadeh Vahid , Valizadeh Leila , Khajehgoodari Mohammad , Bagheriyeh Farzaneh
Published: October 2021

Background

Nurses are at the forefront of patient care during infectious disease pandemics and they play a key role in treating and preventing the upward trend of the disease. Hence, it is crucial to consider their experiences in designing action plans to combat coronavirus disease 2019 (COVID-19). Since there is not enough data in this regard, the current study aimed to investigate the nurses’ experiences in caring for patients with COVID-19 in Iran.

Methods

In this descriptive qualitative study, a total of 20 nurses were selected by purposive sampling. Semi-structured interviews were conducted and analyzed using qualitative content analysis to collect data.

Results

Data analysis revealed four main themes, including ‘duality in the form of care,’ ‘confusion and ambiguity in care planning’, ‘workload’, and ‘social isolation in spite of positive image.’

Conclusion

Our findings indicated that the nurses experienced a range of paradoxes during the COVID-19 pandemic; these paradoxes included distraction from providing care due to focus on marginal factors in spite of empathy and cooperation in nurses, the presence of volunteer support staff despite the lack of equipment, lack of scientific information and the unreliability of online information, overload in the hospital due to insufficient facilities and equipment, and the physical avoidance of people in the community in spite of social support for nurses in the media. The results of this study can lead to a clear understanding for managers and healthcare policymakers in the country and aid them in taking optimal measures to support nurses and improve the quality of nursing care against COVID-19.
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling
Authors: Gu Yang , Wang Yanying , He Luyun , Zhang Jiahang , Zhu Xiaoxiao , Liu Nian , Wang Jianyi , Lu Tiankun , He Lei , Tian Yong , Fan Zusen
Published: October 2021

Background

Hepatocellular carcinoma (HCC) is one of the most intractable tumors in the world due to its high rate of recurrence and heterogeneity. Liver cancer initiating cells also called cancer stem cells (CSCs) play a critical role in resistance against typical therapy and high tumor-initiating potential. However, the role of the novel circular RNA (circRNA) circIPO11 in the maintenance of liver cancer initiating cells remains elusive.

Methods

CircRNAs highly conserved in humans and mice were identified from 3 primary HCC samples by circRNA array. The expression and function of circIPO11 were further evaluated by Northern blot, limiting dilution xenograft analysis, chromatin isolation by RNA purification-PCR assay (ChIRP) and HCC patient-derived tumor cells (PDC) models. CircIpo11 knockout (KO) mice were generated by a CRISPR/Cas9 technology.

Results

CircIPO11 is highly expressed in HCC tumor tissues and liver CSCs. CircIPO11 is required for the self-renewal maintenance of liver CSCs to initiate HCC development. Mechanistically, circIPO11 recruits TOP1 to GLI1 promoter to trigger its transcription, leading to the activation of Hedgehog signaling. Moreover, GLI1 is also highly expressed in HCC tumor tissues and liver CSCs, and TOP1 expression levels positively correlate with the metastasis, recurrence and survival of HCC patients. Additionally, circIPO11 knockout in mice suppresses the progression of chemically induced liver cancer development.

Conclusion

Our findings reveal that circIPO11 drives the self-renewal of liver CSCs and promotes the propagation of HCC via activating Hedgehog signaling pathway. Antisense oligonucleotides (ASOs) against circIPO11 combined with TOP1 inhibitor camptothecin (CPT) exert synergistic antitumor effect. Therefore, circIPO11 and the Hedgehog signaling pathway may provide new potential targets for the treatment of HCC patients.
Zanubrutinib monotherapy in relapsed/refractory mantle cell lymphoma: a pooled analysis of two clinical trials
Authors: Zhou Keshu , Zou Dehui , Zhou Jianfeng , Hu Jianda , Yang Haiyan , Zhang Huilai , Ji Jie , Xu Wei , Jin Jie , Lv Fangfang , Feng Ru , Gao Sujun , Zhou Daobin , Tam Constantine S. , Simpson David , Wang Michael , Phillips Tycel J. , Opat Stephen , Huang Zhiyue , Lu Huafei , Song Yuqin , Song Yongping
Published: October 2021

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm with a high initial response rate followed almost invariably by relapse. Here we report the pooled data from 2 studies, BGB-3111-AU-003 and BGB-3111-206, to explore the efficacy of zanubrutinib monotherapy in relapsed/refractory (R/R) MCL. A total of 112 patients were included. Median follow-up durations were 24.7 and 24.9 months for BGB-3111-AU-003 and BGB-3111-206, respectively. Overall response rate (ORR) and complete response (CR) rate were 84.8% and 62.5%, and median duration of response, progression-free survival (PFS) and overall survival (OS) were 24.9, 25.8 and 38.2 months, respectively. After weighting, the PFS (median: NE vs. 21.1 months,P = 0.235) and OS (median: NE vs. 38.2 months,P = 0.057) were similar but numerically better in the second-line than later-line group. Zanubrutinib was well-tolerated with treatment discontinuation and dose reduction for adverse events in 12.5% and 2.7% of patients, respectively. Hypertension, major hemorrhage and atrial fibrillation/flutter rates were 11.6%, 5.4% and 1.8%, respectively. Zanubrutinib is efficacious in R/R MCL, with a favorable safety profile.
Artificial intelligence enables comprehensive genome interpretation and nomination of candidate diagnoses for rare genetic diseases
Authors: De La Vega Francisco M. , Chowdhury Shimul , Moore Barry , Frise Erwin , McCarthy Jeanette , Hernandez Edgar Javier , Wong Terence , James Kiely , Guidugli Lucia , Agrawal Pankaj B. , Genetti Casie A. , Brownstein Catherine A. , Beggs Alan H. , Löscher Britt-Sabina , Franke Andre , Boone Braden , Levy Shawn E. , Õunap Katrin , Pajusalu Sander , Huentelman Matt , Ramsey Keri , Naymik Marcus , Narayanan Vinodh , Veeraraghavan Narayanan , Billings Paul , Reese Martin G. , Yandell Mark , Kingsmore Stephen F.
Published: October 2021

Background

Clinical interpretation of genetic variants in the context of the patient’s phenotype is becoming the largest component of cost and time expenditure for genome-based diagnosis of rare genetic diseases. Artificial intelligence (AI) holds promise to greatly simplify and speed genome interpretation by integrating predictive methods with the growing knowledge of genetic disease. Here we assess the diagnostic performance of Fabric GEM, a new, AI-based, clinical decision support tool for expediting genome interpretation.

Methods

We benchmarked GEM in a retrospective cohort of 119 probands, mostly NICU infants, diagnosed with rare genetic diseases, who received whole-genome or whole-exome sequencing (WGS, WES). We replicated our analyses in a separate cohort of 60 cases collected from five academic medical centers. For comparison, we also analyzed these cases with current state-of-the-art variant prioritization tools. Included in the comparisons were trio, duo, and singleton cases. Variants underpinning diagnoses spanned diverse modes of inheritance and types, including structural variants (SVs). Patient phenotypes were extracted from clinical notes by two means: manually and using an automated clinical natural language processing (CNLP) tool. Finally, 14 previously unsolved cases were reanalyzed.

Results

GEM ranked over 90% of the causal genes among the top or second candidate and prioritized for review a median of 3 candidate genes per case, using either manually curated or CNLP-derived phenotype descriptions. Ranking of trios and duos was unchanged when analyzed as singletons. In 17 of 20 cases with diagnostic SVs, GEM identified the causal SVs as the top candidate and in 19/20 within the top five, irrespective of whether SV calls were provided or inferred ab initio by GEM using its own internal SV detection algorithm. GEM showed similar performance in absence of parental genotypes. Analysis of 14 previously unsolved cases resulted in a novel finding for one case, candidates ultimately not advanced upon manual review for 3 cases, and no new findings for 10 cases.

Conclusions

GEM enabled diagnostic interpretation inclusive of all variant types through automated nomination of a very short list of candidate genes and disorders for final review and reporting. In combination with deep phenotyping by CNLP, GEM enables substantial automation of genetic disease diagnosis, potentially decreasing cost and expediting case review.
Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers
Authors: Matreyek Kenneth A. , Stephany Jason J. , Ahler Ethan , Fowler Douglas M.
Published: October 2021

Background

PTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability. Experimental characterization can help guide the clinical interpretation of the thousands of germline or somatic PTEN variants observed in patients. Two large-scale mutational datasets, one for PTEN variant intracellular abundance encompassing 4112 missense variants and one for lipid phosphatase activity encompassing 7244 variants, were recently published. The combined information from these datasets can reveal variant-specific phenotypes that may underlie various clinical presentations, but this has not been comprehensively examined, particularly for somatic PTEN variants observed in cancers.

Methods

Here, we add to these efforts by measuring the intracellular abundance of 764 new PTEN variants and refining abundance measurements for 3351 previously studied variants. We use this expanded and refined PTEN abundance dataset to explore the mutational patterns governing PTEN intracellular abundance, and then incorporate the phosphatase activity data to subdivide PTEN variants into four functionally distinct groups.

Results

This analysis revealed a set of highly abundant but lipid phosphatase defective variants that could act in a dominant-negative fashion to suppress PTEN activity. Two of these variants were, indeed, capable of dysregulating Akt signaling in cells harboring a WT PTEN allele. Both variants were observed in multiple breast or uterine tumors, demonstrating the disease relevance of these high abundance, inactive variants.

Conclusions

We show that multidimensional, large-scale variant functional data, when paired with public cancer genomics datasets and follow-up assays, can improve understanding of uncharacterized cancer-associated variants, and provide better insights into how they contribute to oncogenesis.
CDKN2B-AS1 participates in high glucose-induced apoptosis and fibrosis via NOTCH2 through functioning as a miR-98-5p decoy in human podocytes and renal tubular cells
Authors: Xiao Min , Bai Shoujun , Chen Jing , Li Yaxi , Zhang Shu , Hu Zhao
Published: October 2021

Background

Diabetic nephropathy (DN) is the most common causes of end-stage renal disease. Long non-coding RNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) is connected with the development of DN, but the role of CDKN2B-AS1 in DN has not been entirely elucidated.

Methods

Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to measure CDKN2B-AS1 and miR-98-5p levels. Cell viability, proliferation, and apoptosis were analyzed with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) or flow cytometry assays. Protein levels were measured by western blotting. The relationship between CDKN2B-AS1 or notch homolog 2 (NOTCH2) and miR-98-5p was verified via dual-luciferase reporter assay.

Results

CDKN2B-AS1 and NOTCH2 were upregulated in the serum of DN patients and high glucose-disposed human podocytes (HPCs) and human renal tubular cells (HK-2), whereas miR-98-5p was downregulated. High glucose repressed viability and accelerated apoptosis of HPCs and HK-2 cells. CDKN2B-AS1 knockdown impaired high glucose-induced apoptosis and fibrosis of HPCs and HK-2 cells. Mechanistically, CDKN2B-AS1 sponged miR-98-5p to regulate NOTCH2 expression. Also, CDKN2B-AS1 inhibition-mediated effects on apoptosis and fibrosis of high glucose-disposed HPCs and HK-2 cells were weakened by miR-98-5p inhibitor. Also, NOTCH2 knockdown partly reversed miR-98-5p inhibitor-mediated impacts on apoptosis and fibrosis of high glucose-disposed HPCs and HK-2 cells.

Conclusion

High glucose-induced CDKN2B-AS1 promoted apoptosis and fibrosis via the TGF-β1 signaling mediated by the miR-98-5p/NOTCH2 axis in HPCs and HK-2 cells.
Connecting breast cancer survivors for exercise: protocol for a two-arm randomized controlled trial
Authors: Smith-Turchyn Jenna , McCowan Michelle E. , O’Loughlin Erin , Fong Angela J. , McDonough Meghan H. , Santa Mina Daniel , Arbour-Nicitopoulos Kelly P. , Trinh Linda , Jones Jennifer M. , Bender Jackie L. , Culos-Reed S. Nicole , Tomasone Jennifer R. , Vani Madison F. , Sabiston Catherine M.
Published: October 2021

Background

Peer-based exercise interventions that cultivate new opportunities for support with a fellow cancer survivor may result in increased exercise volume. It is not clear whether adding qualified exercise professional (QEP) support to peer-based interventions improves health outcomes. Therefore, the purpose of this study is to determine whether breast cancer survivor (BCS) dyads who receive 10 weekly sessions of virtually delivered QEP support have improved outcomes compared to BCS dyads who do not receive QEP support.

Methods

Participants Adult BCS with medical clearance for exercise, who have an internet-connected device, and currently engage in < 150 min of moderate-intensity exercise per week. Intervention BCS will be matched using evidence-based criteria. The intervention group will receive dyadic exercise information sessions and a program tailored by a QEP for 10 weeks (intervention period) and have access to the QEP for an additional 4 weeks (tapering period). The control will not receive any QEP support. Outcomes The primary outcome is post-intervention self-reported exercise volume. Secondary outcomes include device-assessed exercise volume (i.e., Fitbit), social support, and health-related quality of life. Randomization 108 participants, matched in dyads, will be randomized 1:1 to the MatchQEP or Match groups using a web-based scheme. Statistical analysis Outcomes will be measured at baseline, post-intervention, post-tapering, and at 12 weeks post-intervention follow-up.

Discussion

The findings from this RCT will determine if matched BCS dyads who receive 10 weeks of virtually delivered QEP support have higher levels of self-report and device-measured exercise, social support, and health related quality of life compared to matched dyads without QEP-delivered exercise guidance. To our knowledge this will be the first study to assess the combined effect of peer- and QEP support on exercise volume. Project findings will inform and optimize intervention methods aimed to increase exercise among BCS through accessible exercise supports.

Trial Registration: The study is registered on ClinicalTrials.gov (study identifier: NCT04771975, protocol Version Number: 2, date: July 22, 2021).
Mathematical analysis of hepatitis B epidemic model with optimal control
Authors: Zada Inam , Naeem Jan Muhammad , Ali Nigar , Alrowail Dalal , Sooppy Nisar Kottakkaran , Zaman Gul
Published: October 2021

Infection of hepatitis B virus (HBV) is a global health problem. We provide the study about hepatitis B virus dynamics that can be controlled by education campaign (awareness), vaccination, and treatment. Initially we bring constant controls in considerations for treatment, vaccination, and education campaign (awareness). In the case of constant controls, we study the stability and existence of the disease-free and endemic equilibria model’s solutions. Afterwards, we take time as a control and formulate the suitable optimal control problem, acquire optimal control strategy in order to reduce the number of humans that are infected and the costs associated. At the end, results of numerical simulations show that the optimal combination of education campaign (awareness), treatment, and vaccination is the most efficient way to control the infection of hepatitis B virus (HBV) infection.
The efficacy and safety of high-flow nasal cannula therapy in patients with COPD and type II respiratory failure: a meta-analysis and systematic review
Authors: Xu Zhiping , Zhu Lingxia , Zhan Jingye , Liu Lijun
Published: October 2021

Background

High-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) have been used for the treatment of COPD and respiratory failure in clinical settings. We aimed to evaluate the efficacy and safety of HFNC therapy in patients with COPD and type II respiratory failure, to provide evidence to the clinical COPD management.

Methods

We searched Cochrane et al. databases up to Dec 31, 2020 for randomized controlled trials (RCTs) on the use of HFNC therapy in patients with COPD and type II respiratory failure. Two researchers independently screened the literature according to the inclusion and exclusion criteria, and evaluated the quality of the literature and extracted data. We used Revman5.3 software for statistical analysis of collected data.

Results

A total of 6 RCTs involving 525 COPD and type II respiratory failure patients. Meta-analyses indicated that compared with NIV, HFNC could significantly reduce PaCO2 level (MD = − 2.64, 95% CI (− 3.12 to − 2.15)), length of hospital stay ((MD = – 1.19, 95 CI (− 2.23 to − 0.05)), the incidence of nasal facial skin breakdown ((OR = 0.11, 95% CI (0.03–0.41)). And there were no significant differences between the two groups in PaO2 ((MD = 2.92, 95% CI (− 0.05 to 5.90)), incidence of tracheal intubation ((OR = 0.74, 95% CI (0.34–1.59)) and mortality (OR = 0.77, 95% CI (0.28–2.11)).

Conclusions

HFNC is more advantageous over NIV in the treatment of COPD and type II respiratory failure. Future studies with larger sample size and strict design are needed to further elucidate the role of HFNC in COPD and respiratory failure.
Consumer reviews analysis on cycling pants in online shopping malls using text mining
Authors: Kim Chunjeong , Na Youngjoo
Published: October 2021

This study was investigated trends and consumer awareness on cycling pants by analyzing the reviews on bib shorts, bib tights, shorts, and tights in online shopping malls using text mining. The reviews and product information on cycling pants from Jan. 2017 to the first half of 2020 were crawled, and a total of 7241 cases were analyzed. The keywords of cycling pants were extracted using a Korean morphological analyzer (KoNLP), calculated to the term-document matrix, and then converted into a co-occurrence matrix. The number of reviews of cycling pants increased by 39% per year, and especially in the first half of 2020, the number of reviews has doubled over compared to the first half of last year. Bib shorts accounted for more than 50% of the number of reviews of cycling pants and received the highest rating, making them the most preferred. Positive reviews on cycling pants appeared 15 times over than that of negative reviews, and most of the cycling pants were evaluated positively. Size and cost-effective appeared as the important keywords both in positive and negative reviews. However, it was found that consumers have a difficult time choosing the size not only in the negative but also in the positive reviews. Pad was the keyword that appeared the most in negative reviews, and it was the most dissatisfied factor in the cycling pants. Therefore, in an internet shopping mall, it is necessary to provide intuitive and accurate information that is easy for consumers to understand about information on the size and pad of the cycle pants.
Sudden circulatory collapse caused by mechanical obstruction of the left main coronary trunk with infective endocarditis vegetation: a case report
Authors: Usui Rena , Mutsuga Masato , Narita Yuji , Tokuda Yoshiyuki , Terazawa Sachie , Ito Hideki , Uchida Wataru , Usui Akihiko
Published: October 2021

Background

Acute coronary syndrome (ACS) caused by mechanical obstruction of the coronary artery with a vegetation is extremely rare but associated with high mortality. The optimal management strategy of this condition remains controversial because of its scarcity. We experienced a case of sudden circulatory collapse due to mechanical occlusion of the left main coronary trunk with a vegetation.

Case presentation

A 68-year-old woman with aortic and mitral valve infective endocarditis suffered sudden dyspnea followed by heart arrest while awaiting surgery. Despite treatment with adequate antibiotic therapy, she had had multiple embolic infarctions and ruptured infectious cerebral aneurysms. We conducted transcatheter arterial embolization of the aneurysm and postponed the cardiac surgery due to residual aneurysmal blood flow. She suffered sudden cardiac arrest, and extracorporeal membrane oxygenation was applied after cardiopulmonary resuscitation. An echocardiogram revealed diffuse severe hypokinesis, and emergency coronary angiography was performed under suspicion of ACS. It revealed obstruction of the left main coronary trunk by a vegetation. Emergent cardiac surgery was performed. A vegetation had occluded the left coronary orifice. Aortic and mitral valve replacement with coronary artery bypass to the left antero-descending branch was performed. Regarding her cardiac function, she still required extracorporeal membrane oxygenation after surgery. She passed away 19 days after surgery due to multiple organ failure.

Conclusions

ACS caused by mechanical obstruction of the coronary artery with a vegetation is rare but associated with high mortality. When circulatory collapse acutely occurs in patients with aortic valve infective endocarditis, we should suspect acute coronary artery obstruction. Urgent coronary angiography is mandatory to rescue the patient while preparing for emergency surgery.
Adding value to food chain information: using data on pig welfare and antimicrobial use on-farm to predict meat inspection outcomes
Authors: Pessoa Joana , McAloon Conor , Rodrigues da Costa Maria , García Manzanilla Edgar , Norton Tomas , Boyle Laura
Published: October 2021

Background

Using Food Chain Information data to objectively identify high-risk animals entering abattoirs can represent an important step forward towards improving on-farm animal welfare. We aimed to develop and evaluate the performance of classification models, using Gradient Boosting Machine algorithms that utilise accurate longitudinal on-farm data on pig health and welfare to predict condemnations, pluck lesions and low cold carcass weight at slaughter.

Results

The accuracy of the models was assessed using the area under the receiver operating characteristics (ROC) curve (AUC). The AUC for the prediction models for pneumonia, dorsocaudal pleurisy, cranial pleurisy, pericarditis, partial and total condemnations, and low cold carcass weight varied from 0.54 for pneumonia and 0.67 for low cold carcass weight. For dorsocaudal pleurisy, ear lesions assessed on pigs aged 12 weeks and antimicrobial treatments (AMT) were the most important prediction variables. Similarly, the most important variable for the prediction of cranial pleurisy was the number of AMT. In the case of pericarditis, ear lesions assessed both at week 12 and 14 were the most important variables and accounted for 33% of the Bernoulli loss reduction. For predicting partial and total condemnations, the presence of hernias on week 18 and lameness on week 12 accounted for 27% and 14% of the Bernoulli loss reduction, respectively. Finally, AMT (37%) and ear lesions assessed on week 12 (15%) were the most important variables for predicting pigs with low cold carcass weight.

Conclusions

The findings from our study show that on farm assessments of animal-based welfare outcomes and information on antimicrobial treatments have a modest predictive power in relation to the different meat inspection outcomes assessed. New research following the same group of pigs longitudinally from a larger number of farms supplying different slaughterhouses is required to confirm that on farm assessments can add value to Food Chain Information reports.
Preferences on how to measure and discuss health related quality of life within integrated care for children with obesity
Authors: Eilander Minke M. A. , van Mil Marieke M. A. , Koetsier Leandra W. , Seidell Jacob C. , Halberstadt Jutka
Published: October 2021

Background

Childhood obesity can affect physical as well as psychosocial wellbeing. Therefore, childhood obesity care aims to improve all dimensions of health related quality of life (HRQoL). HRQoL can be measured with the generic questionnaire PedsQL4.0 and the weight-specific IWQOL-Kids. In the Netherlands, HRQoL assessment is conducted by the coordinating professional (CP). The aim of this qualitative study was to examine how and when to implement the measurement and discussion of HRQoL using the PedsQL4.0 and IWQOL-Kids within the integrated care for children with obesity in the Netherlands. Semi-structured interviews were conducted with fourteen CPs, in which the following was discussed: a) familiarity and attributions with regard to the assessment of HRQoL; b) wishes and needs with regard to the usage of the questionnaires; c) its practical incorporation.

Results

Interviews revealed that most CPs gained insight into the HRQoL by talking with families. One CP used the PedsQL4.0, the remaining CPs were unfamiliar with the two questionnaires. Even though some barriers, for instance a lack of time, might hinder the implementation of the PedsQL4.0 and IWQOL-Kids, all participants think the usage of either one or both questionnaires would have additional value to the support and care for children with obesity. There was no consensus about the questionnaire of preference.

Conclusions

When the right preconditions are met, HRQoL questionnaires have the potential to support CPs in improving the care for children with obesity, tailored to each individual child.
Malignant giant solitary fibrous tumour of the mediastinum; masquerading Triton tumour
Authors: Beg Arshi , Parikh Jeenal , Janu Amit , Kaushal Rajiv Kumar
Published: October 2021

Background

Malignant Solitary fibrous tumour (SFT) is an uncommon mesenchymal tumour with aggressive clinical behaviour as compared to its benign counterpart. There are only a handful of reports of extra-pleural malignant SFT arising from the mediastinum.

Case presentation

A 68-year-old male, presented with a history of cough and breathlessness for 2 weeks. Computed tomography (CT) scan revealed a large 11.6 × 11.3x18cm anterior mediastinal mass with extension to right hemithorax. The patient underwent excision of the mass after a biopsy confirmation of mesenchymal tumour. Histological examination of resection specimen revealed a spindle cell tumour with hypo and hypercellular areas, arranged in fascicular, focal storiform and hemangio-pericytomatous vasculature pattern. Moderate to marked nuclear atypia, frequent mitosis and areas of necrosis were noted. On immunohistochemistry (IHC), the tumour cells were positive for CD34, Bcl2, MIC2 (dot-like) and focally for S100 and Desmin. Although, the possibility of a malignant peripheral nerve sheath tumour with heterologous rhadomyosarcomatous differentiation (Triton tumour) was considered, however IHC for STAT6 confirmed it to be a malignant SFT. The patient developed recurrence within 1 year after surgery and despite multi-modality treatment (Re-excision, Chemotherapy and Radiotherapy) succumbed within 14 months from point of presentation.

Conclusion

Malignant SFT is a rare aggressive tumour that should be considered as a differential diagnosis in the mediastinum and a broad panel of IHC markers including STAT6 may be required to confirm the diagnosis.
Comparison between ultrasound-guided and anatomical landmark-guided block of internal branch of the superior laryngeal nerve for awake fiber-optic intubation in suspected difficult intubation: a randomized controlled study
Authors: El Deek Abeer M. , Shafik Azza M. , Eltohry Al Shymaa Mortada Ali , Al Fawal Sanaa Mohamed
Published: October 2021

Background

Airway anesthesia is pivotal for successful awake intubation provided either topically or by nerve blocks. The widespread use of ultrasonography allows anesthesiologists to evaluate complex and varied anatomy before needle insertion. This study aims to evaluate the effect of ultrasound-guided technique for the block of the internal branch of the superior laryngeal nerve in difficult airway patients in comparison to blind anatomical technique. Sixty patients aged 18–60 years, of either sex, with the American Society of Anesthesiologists’ physical status (ASA) I–II were divided into two groups 30 patients of each. Group (L): using anatomical landmark technique to bilateral block internal branch of the superior laryngeal nerve (ibSLN) with 1 mL 2% Lidocaine and group (U): using ultrasound technique to bilateral block the ibSLN with 1 mL 2% Lidocaine. Assessment of the excellence of airway anesthesia during intubation by using the 5 points grading scale, time for intubation, effects on hemodynamic variables, and evaluation of patient awareness of pain and discomfort during fiber-optic intubation using numerical rating scale were compared.

Results

The duration of tracheal intubation was shorter in the ultrasound group as compared to the anatomical group; also, patient comfort was significantly better in the ultrasound group besides the effect of tracheal intubation on hemodynamics which was significant with a higher peak value during intubation and post-intubation in the anatomical group compared to the ultrasound group.

Conclusions

This study concludes that an ultrasound-guided block of ibSLN used as a part of the preparation of the airway for awake fiber-optic intubation enhances the quality of airway anesthesia and patient tolerance during the procedure.
Removal of Isolan Dark Blue 2SGL-01 from aqueous solutions onto calcined and uncalcined (Mg-Zn)/(Al-Fe)-(CO3)/Cl layered double hydroxides
Authors: Kenawy Ibrahim M. M. , Hafez Medhat A. H. , Mousa Abdalla A. , Elbary Zainab Abd , Abou-El-Sherbini Khaled S.
Published: October 2021

The adsorption process of the industrialized dye Isolan Dark Blue 2SGL-01 (IDB) onto (Mg-Zn)/(Al-Fe)-(CO3)/Cl layered double hydroxides (LDHs) coded LDH21 and LDH22 and its calcined products CLDHs (CLDH21 and CLDH22), respectively, was investigated. The characterization of LDHs and CLDHs before and after loading with IDB by Fourier transform infrared, scanning electron microscope and surface area measurements showed a typical hydrotalcite structure and confirmed the loading of IDB. The adsorption parameters; initial pH, shaking time, adsorbent dose, initial concentration of IDB dye and temperature were studied. The optimum conditions for IDB adsorption were pH 4.3 and shaking time 3 h. A complete removal of IDB (> 99%) was achieved using a dosage of 2.0 g L− 1 CLDHs or LDH22, and 3.0 g L− 1 of LDH21. The adsorption processes were suggested to be best described by the pseudo-second order kinetics and Langmuir-type adsorption isotherm with monolayer capacities of 75, 91, 427 and 530 mg g− 1, onto LDH21, LDH22, CLDH21 and CLDH22, respectively. The loaded IDB was recovered from LDHs and CLDHs adsorbent using Na2CO3. CLDH22 showed best adsorption capacity of 530 mg g− 1. Its adsorption thermodynamic parameters ∆Gadsorption, ∆Hadsorption and ∆Sadsorption indicated that the adsorption processes were spontaneous and endothermic in nature. CLDH22 was successfully applied for the removal of IDB from simulated dyeing process with removal efficiency 97%.
Knowledge, attitudes and practices survey of cardiac rehabilitation among cardiologists and cardiac surgeons in Lebanon
Authors: Farah Rebecca , Groot Wim , Pavlova Milena
Published: October 2021

Background

Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. Over three quarters of the cardiovascular deaths take place in low and middle-income countries. Despite the benefits, Cardiac Rehabilitation (CR) is still not routinely and not universally available. Numerous studies have found that barriers to access to CR are correlated with providers, patients and environment characteristics. This first national survey on CR in Lebanon assesses the knowledge, attitudes and practices among physicians. In addition, the study identifies what the main barriers to access to CR are and provides suggestions for the implementation of CR in the country.

Results

The response rate was 41.5% (n = 83). Results show that the cardiologists have medium level of knowledge about CR and its multidisciplinary content. Physicians support the implementation of a comprehensive CR program in the country. 50% of the physicians recommended first to solve the financial issues before implementing a CR program. Supplementary learning about the benefits of CR is highly recommended to enroll more patients with CVD into CR. In addition, the lack of specialists in the field, lack of motivation for patients to enroll to CR and inconvenient location of the rehabilitation centers were identified as major barriers by the respondents.

Conclusions

The role of physicians in promoting patient enrolment should be optimized and exploited in the country. The access barriers identified can help to develop CR programs and to improve CR referral and enrolment rates. Funds from private parties and a budget from the government are needed to launch new CR programs in the country. Further research is needed to provide evidence on the CR benefits in Lebanon and to motivate policy-makers to place priority on the establishment of a comprehensive CR program in the country.
Studying the behavior of geopolymer concretes under repeated loadings
Authors: Al-Kerttani Osamah M. G. , Mutar Ammar
Published: October 2021

This article investigates utilization of polypropylene microfibers as reinforcement in geopolymer concrete to enhance the ductility characteristics since the geopolymer concrete is considered a brittle material. The polypropylene microfibers were added to geopolymer concrete at the fiber volume content of 0.5%, 1.0%, and 1.5%. In this article, a slump test and compressive strength were tested for geopolymer concretes to measure the effect of polypropylene microfibers on geopolymer concretes. Also, static flexural strength and dynamic loading were applied to find out the attitude of polypropylene fiber-reinforced geopolymer concrete and to measure both the deflection and number of load cycles until failure. While comparing the results with reference geopolymer concrete, all samples were tested at 28 days and, finally, a statistical test was carried out. The results concluded that the use of polypropylene microfibers improves the compressive strength and enhances the properties of polypropylene fiber-reinforced geopolymer concretes, increases the loading for the appearance of the first crack, and decreases the deflection of polypropylene fiber-reinforced geopolymer concretes compared with reference geopolymer concrete.
Mechanical movement data acquisition method based on the multilayer neural networks and machine vision in a digital twin environment
Authors: Li Hao , Liu Gen , Wang Haoqi , Wen Xiaoyu , Xie Guizhong , Luo Guofu , Zhang Shuai , Yang Miying
Published: October 2021

Background: Digital twin requires virtual reality mapping and optimization iteration between physical devices and virtual models. The mechanical movement data collection of physical equipment is essential for the implementation of accurate virtual and physical synchronization in a digital twin environment. However, the traditional approach relying on PLC (programmable logic control) fails to collect various mechanical motion state data. Additionally, few investigations have used machine visions for the virtual and physical synchronization of equipment. Thus, this paper presents a mechanical movement data acquisition method based on multilayer neural networks and machine vision.

Methods: Firstly, various visual marks with different colors and shapes are designed for marking physical devices. Secondly, a recognition method based on the Hough transform and histogram feature is proposed to realize the recognition of shape and color features respectively. Then, the multilayer neural network model is introduced in the visual mark location. The neural network is trained by the dropout algorithm to realize the tracking and location of the visual mark. To test the proposed method, 1000 samples were selected.

Results: The experiment results shows that when the size of the visual mark is larger than 6mm, the recognition success rate of the recognition algorithm can reach more than 95%. In the actual operation environment with multiple cameras, the identification points can be located more accurately. Moreover, the camera calibration process of binocular and multi-eye vision can be simplified by the multilayer neural networks.

Conclusions: This study proposes an effective method in the collection of mechanical motion data of physical equipment in a digital twin environment. Further studies are needed to perceive posture and shape data of physical entities under the multi-camera redundant shooting.
The genome sequence of the garden bumblebee, Bombus hortorum (Linnaeus, 1761)
Authors: Crowley Liam ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: October 2021

We present a genome assembly from an individual female Bombus hortorum (the garden bumblebee; Arthropoda; Insecta; Hymenoptera; Apidae). The genome sequence is 296 megabases in span. The majority of the assembly is scaffolded into 18 chromosomal pseudomolecules.
Acoustics and Resonance in Poetry: The Psychological Reality of Rhyme in Baudelaire’s “Les Chats”
Authors: Tsur Reuven
Published: October 2021

This article uses the term “psychological reality” in this sense: the extent to which the constructs of linguistic theory can be taken to have a basis in the human mind, i.e., to somehow be reflected in human cognitive structures. This article explores the human cognitive structures in which the constructs of phonetic theory may be reflected. The last section is a critique of the psychological reality of sound patterns in Baudelaire’s “Les Chats”, as discussed in three earlier articles. In physical terms, it defines “resonant” as “tending to reinforce or prolong sounds, especially by synchronous vibration”. In phonetic terms it defines “resonant” as “where intense precategorical auditory information lingers in short-term memory”. The effect of rhyme in poetry is carried by similar overtones vibrating in the rhyme fellows, resonating like similar overtones on the piano. In either case, we do not compare overtones item by item, just hear their synchronous vibration. I contrast this conception to three approaches: one that points out similar sounds of “internal rhymes”, irrespective of whether they may be contained within the span of short-term memory (i.e., whether they may have psychological relit); one that claims that syntactic complexity may cancel the psychological reality of “internal rhymes” (whereas I claim that it merely backgrounds rhyme); and one that found through an eye-tracking experiment that readers fixate longer on verse-final rhymes than on other words, assuming regressive eye-movement (I claim that rhyme is an acoustic not visual phenomenon; and that there is a tendency to indicate discontinuation by prolonging the last sounds in ordinary speech and blank verse too, as well as in music — where no rhyme is involved).
How Software Features and Linguistic Analyses Add Value to Orthographic Markup in Transcription of Multilingual Recordings for Digital Archives
Authors: Rodriguez Enrique , Vann Robert
Published: October 2021

This report discusses the importance of accounting for language contact and discourse circumstance in orthographic transcriptions of multilingual recordings of spoken language for deposit in digital language archives (DLAs). Our account provides a linguistically informed approach to the multilingual representation of spontaneous speech patterns, taking steps toward documenting ancestral and emergent codes. Our findings lead to portable lessons learned including (a) the conclusion that transcriptions can benefit from a bottom-up approach targeting particular linguistic features of sociocultural relevance to the community documented and (b) the implication (for researchers developing transcriptions for other DLAs) that the principled implementation of particular software features in tandem with systematic linguistic analysis can be helpful in finding and classifying such features, especially in multilingual recordings.
Valoración histórica y patrimonial de las ciudades embrionarias: el caso de Mexicali, México
Authors: Olvera García Daniel Antonio , Vizcarra Berenice
Published: October 2021

Dado que muchas de las ciudades de reciente creación han atravesado un proceso de crecimiento y maduración acelerado que, en algunos casos, no ha permitido una documentación adecuada lo que, a su vez, ha provocado que elementos básicos de su evolución se vean perdidos; el trabajo que aquí se presenta tiene el objetivo de elaborar un marco teórico de investigación basada en la revisión bibliográfica del desarrollo urbano-arquitectónico del cuadro histórico de una de estas ciudades embrionarias: Mexicali, México, la cual está conformada por tres sectores que, a su vez, representan la propia estructura de la mancha urbana; es decir, al centro las activida­des mixtas, al oriente la vivienda residencial y al poniente los asentamientos populares. Este planteamiento tiene la finalidad de exponer los aspectos fundamentales que caracterizaron este centro fundacional, entender tanto sus cambios como su deterioro e identificar las potenciali­dades para su valoración histórica y patrimonial.
Conversando com Paulo Freire - Diálogos dentro e fora do PPGEDUC/UFRRJ
Authors: Silva Nathalia De Souza , Santos Edméa Oliveira dos , Malachias Rosângela
Published: October 2021

“Conversando com Paulo Freire” é um dispositivo formativo, cunhado pela comissão de comunicação do PPGEDUC/UFRRJ, para homenagear e atualizar a obra de Paulo Freire, que neste ano de 2021 comemora seu centenário de vida. Paulo Freire é patrono da educação brasileira, nosso autor mais citado nacionalmente e internacionalmente. Sua obra e memória vêm sofrendo golpes diante do cenário de desgoverno que se institui em nosso país nos últimos anos. O Programa de Pós-graduação da Universidade Federal Rural do Rio de Janeiro organizou o dispositivo, que acontece mensalmente de abril a dezembro de 2021, não só para homenagear Paulo Freire, mas também para apresentá-lo para as novas gerações. Sempre com a mediação de uma ou um docente do programa, são convidados para o diálogo estudantes ou docentes do programa e parceiros e parceiras intelectuais de fora do programa, promovendo, assim, intercâmbios e redes de colaboração, incluindo pares também de fora do Brasil. Cada convidado apresenta um tema, dialogando com seu interlocutor, instituindo, assim, a conversa entre membros convidados e os participantes que interagem no canal do PPGEDUC Rural no Youtube, via sala de bate-papo (Chat). Os participantes que preenchem e comprovam a participação são certificados, integrando uma grande rede que dialoga com a escola básica, as universidades e diferentes e plurais redes educativas. A live é transmitida ao vivo pelo canal, que também guarda sua memória para reuso. Assim, cada live é em potência um artefato curricular, que pode ser reutilizada em outros contextos, disparando mais e mais diálogos. Diálogos são uma das máximas freirianas, uma vez que só a partir da conversa que podemos garantir o debate democrático para uma educação autêntica. Nosso objetivo é partilhar com os leitores da Revista Docência e Cibercultura, neste número especial, esta produção, na esperança que mais e diferentes “Conversando com Paulo Freire” possam emergir. Também é a nossa forma de homenagear sua memória, que muito nos inspira com sua vigorosa obra, que não separa a docência da discência, a pesquisa da formação, os homens das mulheres e a democracia da justiça social.
PARA UMA “RE-VISÃO” DA CRÍTICA LITERÁRIA DA LITERATURA DE AUTORIA FEMININA: O SUBLIME FEMINISTA NO CONTO “AMOR”, DE CLARICE LISPECTOR
Authors: Mitre Marcus Vinícius De Oliveira , Santos Rosana Cássia Dos
Published: October 2021

Neste artigo pretendemos desenvolver uma análise do conto “Amor”, de Clarice Lispector, que compõe a coletânea Laços de Família (1960), intentando contribuir para a reflexão acerca da crítica literária feminista. Ancorada pela noção de sublime feminino, proposta por Barbara Freeman e retomado por Rosana Cássia Kamita nos termos de um sublime feminista, buscamos compreender como, partindo deste conto em particular, Clarice Lispector trabalha nos limites da representação e propõe desafios à crítica, apontando, nos termos de Adrienne Rich, para a necessidade de uma “re-visão” dos moldes literários canônicos, considerados androcêntricos, e apontando, consequentemente, para uma desestabilização da crítica literária tradicional e para a necessidade de construir um outro olhar para a leitura e compreensão da literatura de autoria feminina.