bluuebunny/crossref_metadata_2025 huggingface dataset:
A comprehensive analysis assessing the impact of climate events on global citizens health: From the aspect of disease and public health
Authors: Zang Dexuan
Published: July 2024

The challenge posed by shifting climatic conditions has emerged as one of the most critical issues of our time, carrying significant implications for human well-being. This research seeks to investigate climate events impact on individual health on a global scale. In order to achieve a comprehensive understanding of the intricate relationship between climate events and the health of global citizens, we analyze a diverse array of data sources, encompassing epidemiological studies, climate records, and health indicators. This study examines the direct and indirect effects of climate events, such as heat waves and extreme weather occurrences drawing upon authoritative epidemiological research. Furthermore, it explores the secondary repercussions of climate-induced disruptions, including alterations in the trend of cardiovascular diseases, which have been observed to heighten the overall health burden. The primary objective of this study is to advance our comprehension of the intricate interplay between climate change and global public health. The findings will underscore the pressing necessity to address climate-changing events as a paramount public health concern, emphasizing the importance of comprehensive, evidence-based policies that safeguard human well-being amidst an increasingly volatile climate. By combining empirical evidence with a broader understanding of social and environmental determinants of health, we aspire to assist decision-makers in implementing proactive measures to protect and promote the health of populations worldwide in the face of a changing climate.
Research on the correlation between toxic aggregation in brain and cell-cell fusion caused by SARS-CoV-2 infection
Authors: Lyu Yanyi
Published: July 2024

Since the outbreak of the COVID-19 pandemic, much research has been done to understand SARS-CoV-2's and COVID-19, the disease it cause. The pathway that the virus relies on to infect cells is through binding of the viral protein to the ACE2 receptor on the surface of host cells. After replication, the virus most often exits the cell by lysosomal exocytosis, which releases the virus into the extracellular space, and the cycle repeats. However, cell-cell fusion caused by SARS-CoV-2 can promote viral spread by fusing neighboring cells to form syncytia, leading to the infection of neighboring cells. One of the major concerns regarding SARS-CoV-2 is the neuroinvasive potential the virus exhibits. Cell-cell fusion is observed in neuronal cells as well, potentially compromising the overall integrity of neuronal activities. Thus, in this research proposal, cell-cell fusion and its impact on brains will be investigated by assaying its influence on protein aggregations in brains. The proposal plans to apply both brain organoids and animal models for assessment. Hypothetically, once cell-cell fusion and formation of protein is observed in brain tissue samples, more information can be revealed towards comprehending the mechanisms of SARS-CoV-2 activities during infection.
Review of mutant p53 protein and the p53 targeting therapy in cancer treatment
Authors: Yin Yue
Published: July 2024

Cancer in humans is a disease that has been difficult to treat due to properties it is able to obtain after being introduced to an organism and has been one of the most prominent points of research in drug development. Since cancers can take on a multitude of forms, a popular strategy employed to find therapies for it is by identifying common features among cancers. A well-known alteration in half of all human cancers is TP53 mutations, of which there are more than 500. This literary review first discusses the additional capabilities cancer cells obtain, then a discussion of the various functions of p53 and the mutations it can take on. The central focus of this review will be an elucidation of the major approaches attempted in the development of cancer treatment through p53: viruses, targeting gain-of-function mutant p53, structural reactivation of mutant p53 to restore wild type activity, the depletion of mutant p53, and targeting mutant p53 through synthetic lethal inhibitors. Through exploring the different therapies, it is a universal goal to elicit one single treatment for mutant p53 that can impact the greatest amount of p53 mutations while retaining the ability to suppress or even prevent and inhibit cancer.
Analyzing the current application status of gefitinib based on the synthetic routes and mechanism of action
Authors: Cui Liyuan , Liu Douqiu , Zhang Yaping
Published: July 2024

This paper focuses on the treatment of lung cancer, which has a high incidence and mortality rate. It highlights the significance of molecularly targeted drugs in anti-tumor therapy and provides an overview of gefitinib, a first-generation inhibitor of epidermal growth factor receptor tyrosine kinase. The article describes the site of action and regulatory mechanism of gefitinib to help understand its pharmacological effects. Three representative synthetic routes of Gefitinib were selected for comprehensive analysis and evaluation, and the optimal route 3 with 4,5-dimethoxy-2-nitrobenzoic acid as the starting raw material and seven steps of demethylation, esterification, side-chain alkylation, reduction, cyclohexylamine, chlorination, and ammonia substitution was chosen by comparing the advantages and disadvantages of the routes. It is the optimal route which is greener and better meets the demand of industrial production. At the same time, this article reviews the effectiveness of gefitinib, its adverse effects, and potential drug resistance. It also highlights the importance of research into the synthetic route of gefitinib, to aid in the design of its production process.
Changes in nutrient intake requirements of terminally ill patients
Authors: Siying Chen
Published: July 2024

The healthcare system is confronted with a growing issue in providing high-quality end-of-life care as the world population through a process of aging. Nutritional support constitutes a crucial element of the care provided to individuals in final stages of illness. However, it is noteworthy that the existing body of research on the precise dietary requirements of terminally ill patients is surprisingly small. The present study conducts a comprehensive evaluation of the literature, rigorously examining a diverse array of academic publications, medical journals, and clinical studies published throughout 1990 to 2021. The paper diligently extracts and amalgamates pertinent information concerning how nutrient intake requirements evolve as patients approach the terminal phase of their illnesses. It underscores significant findings related to shifts in these nutritional needs, considering variables such as disease type, disease stage, and patient-specific factors. Furthermore, the paper delves into the challenges and opportunities associated with providing appropriate nutritional support to terminally ill individuals. This research illuminates the evolving dietary necessities of terminally ill patients, furnishing invaluable insights for healthcare providers, caregivers, and policymakers alike. An understanding of these changes is pivotal for enhancing the quality of life, symptom management, and optimizing the care offered to individuals nearing the end of their lives. Ultimately, this study contributes to the overarching goal of enhancing end-of-life care, ensuring a dignified and comfortable transition for terminally ill patients.
Evaluating the possibility of applying to COVID-19 based on peptide vaccine mechanism
Authors: Wen Xin , Zhang Shurui
Published: July 2024

At the end of 2019, a coronavirus outbreak affecting specific types of pneumonia broke out in Wuhan, China. COVID-19 was initially a rapid infectious disease caused by SARS CoV-2 virus. The main transmission route of COVID-19 is large droplet transmission. When it infects a person, can cause pulmonary fibrosis, and the main symptoms of patients include coughing and respiratory discomfort. This virus causes multiple infections and deaths in a short period of time and rapidly expands globally. Therefore, vaccination is crucial as the most cost-effective method for preventing and controlling the spread of COVID-19. In this context, peptide vaccines have been discovered and continue to receive attention as a new type of vaccine. This article introduces the advantages and drawbacks of peptide vaccine in detail from the source and mechanism of peptide vaccine, subdivides its different mechanisms of action, and further explores how peptide vaccine induces Th1 cell response, germinal center response and humoral immune regulation induced by peptide vaccine, and moral memory cell response in COVID-19. Taking COVID-19 as the background and starting from the existing research, explore the existing problems of existing peptide vaccines and their future development in detail.
A study on supply chain information sharing strategy for emission reduction investment in electronic products based on game theory
Authors: Zhang Xinyin , Cai Yujin
Published: July 2024

By analyzing the competition between electronic product manufacturers and retailers in pricing, a dynamic game model is constructed. Using backward induction, the optimal choices and maximum profits under equilibrium conditions are determined. Finally, the constructed model is subjected to data simulation by setting numerical values for relevant parameters to analyze the effects of environmental emission reduction value on the supply chain and the information sharing value of each member. The following conclusions are drawn: when the emission reduction efficiency of manufacturers or the sensitivity of the market to environmental protection is high, the improvement effect of information sharing will outweigh its bilateral marginal effect. Retailers will voluntarily share all demand information and achieve a win-win situation in the supply chain.
多场景小鼠抑郁装置在抑郁症研究中的应用
Authors: 张 景珂 , 宁 晗 , 赵 扬 , 曹 悦 , 孙 雯涛 , 汤 宁
Published: July 2024

本研究介绍了一种创新性的“多场景小鼠抑郁装置”，旨在为抑郁症研究提供更为贴近人类实际情境的实验模型，用于模拟人类抑郁症患者在实际生活中面临的多重压力环境。该装置通过模拟不同的生活场景，如天敌刺激、冷水游泳等，在小鼠身上诱发抑郁样行为，从而研究抑郁症的发病机制、药物疗效及行为干预策略。本文详细阐述了装置的构成、功能特点。多场景小鼠抑郁装置具有高度的灵活性和可控性，能够精确模拟多种抑郁相关环境，为深入研究抑郁症提供了新的有力工具。可供相关小鼠抑郁模型装置设计研究，有望推动抑郁症诊疗技术的快速发展。
Optimization of service quality management in clinical processes
Authors: Zhang Jiahuang , An Xujie
Published: July 2024

This study aims to explore the specific application and optimization strategies of service management in clinical practice, with the core goal of improving the quality of medical services, enhancing patient satisfaction, and optimizing the allocation of medical resources. Through continuous improvement and optimization of service management strategies, we hope to promote the development of the medical service system towards a healthier and more efficient direction, and provide patients with higher quality and professional medical services. Meanwhile, this effort will also contribute to enhancing the comprehensive competitiveness and social image of medical institutions, laying a solid foundation for building a more harmonious and trustworthy doctor-patient relationship. We believe that through continuous research and practice, we can create a better medical environment for patients and inject new vitality into the development of the medical service industry.
Relationship Between the Consumption of Beverage Use and Its Effects on Oral Health
Authors: Al Hussaini Syed Hussain , Shah Syeda Lalarukh Saba , Shujaat Nazli Gul , Nasir Zarish
Published: July 2024

The current study of beverages as likely contributors to the prevalence of oral diseases in the general population has initiated interest in investigating the association of beverage use and its impact on oral health. Objective: To explore the relationship between beverage consumption and its impact on oral health. Method: Data were gathered from 377 college students for a cross-sectional study by using a convenience sampling technique. The study included male and female students, aged 19-25, excluding those who declined or couldn't communicate in Urdu/English. verbal consent was taken and confidentiality was maintained. A 95% confidence interval and a p-value of equal and < 0.05 were used to identify significant findings. Results: The study included 377 medical and dental college students of which 273 (72.4%) were females and 104 (27.6%) were males. Soft drinks were correlated with dental caries (65.1%) which was followed by sensitivity (14.2%), calculus/plaque (10.7%), and tooth staining (10.1%). Tea consumption was associated with dental caries (54.5%). The relationship between beverage type and its impact on oral health was highly significant (p-value < 0.001). Furthermore, the frequency of beverage consumption and its effect on oral health showed significant results, with a p-value of 0.006. Conclusions: The findings suggest a significant correlation between beverage consumption and various oral health issues, including dental caries, sensitivity, calculus, and staining.
Թվային փոխակերպման հնարավորությունները ՀՀ-ում. Միկրոտվյալների վերլուծություն
Authors: Մակարյան Աննա Ռուզվելտի , Դալլաքյան Սվետլանա Արկադիի
Published: July 2024

Համացանցից օգտվողների նկարագրի, ինչպես նաև օգտագործման ընթացքում հաճախակի կատարվող գործողությունների և հասանելիության տարբերակների վերլուծությունը և դրա արդյունքում թվային վերափոխմանն ուղղված համապատասխան առաջարկությունների ներկայացումը պայմանավորում է տվյալ ուսումնասիրության արդիականությունը: Հոդվածի հիմնական նպատակն է միկրոտվյալների հիման վրա բացահայտել համացանցից օգտվողների նկարագիրը, ներկայացնել վերջիններիս կողմից օգտվելու ընթացքում հաճախակի կատարվող գործողությունները և հասանելիության տարբերակները և ստացված արդյունքների հիման վրա առաջարկել ՀՀ-ում թվային փոխակերպմանն ուղղված համապատասխան քայլեր և միջոցառումներ, որոնք կարող են կիրառվել կառավարության կողմից: Актуальность статьи обусловлена анализом профиля пользователей интернета, а также действий и вариантов доступа, часто выполняемых во время использования, и представлением в результате соответствующих рекомендаций по цифровой трансформации. Цель: на основе микроданных определить описание пользователей, представить основные действия, выполняемые ими при входе в интернет, а также с помощью каких устройств они получают доступ, и на основе полученных результатов предложить соответствующие шаги и меры, направленные на цифровую трансформацию Армении, которые могут быть применены правительством.
The analyses of user profiles and the devices through which the population accesses the internet, as well as what users frequently do while browsing the internet, and providing respective recommendations aimed at digital transformation determines the relevance of the study. The main purpose of the article is to identify the internet user profile using microdata, to present what they mainly do while browsing the internet via which devices they access the Internet as well, and based on the findings propose respective measures and steps aimed at digital transformation to be utilized by the government.
Factors that influence choice of residence by urban informal settlement dwellers in an intermediate city: A case study of Enugu, Nigeria
Authors: Jiburum Uloma , Duyilemi Victor O. , Ogbuefi Paul C. , Nwachukwu Maxwell U.
Published: July 2024

The consequences of urbanization in Sub-Saharan Africa are poverty, insecurity, and the growth of informal settlements. These settlements are characterized by overcrowding, tenure insecurity, a lack of basic services and amenities, and many other deprivations. The current study looks at the social and environmental problems faced by residents and the factors responsible for their choice to reside in an informal settlement in Enugu using the survey research method. Primary and secondary data were utilized in the study. Whereas the former source includes a structured questionnaire and observations, the latter source comprises relevant literature. A total of 111 questionnaires were distributed to household heads in five selected informal settlements in Enugu. The data set was collated and analysed using descriptive and inferential statistics. Principal component analysis was used to classify and determine the factors influencing the choice to reside in an informal settlement. The study revealed that six factors influence the choice of residence in informal settlements: government/political influence, social integration/services, housing/employment, infrastructure accessibility, livelihood costs and security/economy. The factors accounted for 72.11 percent of the factors influencing the choice to reside in an informal settlement. The major social challenges faced by residents are gambling, drug abuse, and overcrowding. The study recommends that low-cost housing that is affordable should be provided for the low-income group that characterizes informal settlements in Enugu metropolis.
Soybean cultivation in short rotation organic crop rotation under different fertilisation systems
Authors: Savchenko E.D.
Published: July 2024

To determine the impact of different types of organic fertilizer systems on the yield and quality of soybean seeds in a short-rotation crop rotation. Methods. Research is conducted at the Panfil Research Station of the National Scientific Center «Institute of Agriculture of NAAS» in a stationary experiment established in 2021 on typical low-humus chernozem. Results. According to the research results, soybean cultivation in a short-term organic crop rotation: soybean (Glycine max (L.) Merrill) – spring wheat (Triticum aestivum L.) – common millet (Panicum miliaceum L.) with using different types of biological fertilizer was quite effective. Thus, the yield of soybean seeds, depending on the organic fertilization system, was in the range of 1.28–1.68 t/ha, with a protein and fat content of 39.50–41.55 and 18.67–21.25 %, respectively. Conclusions. The maximum conditional net profit of 5.48 thousand UAH/ha with a profitability level of 144 % was provided by the integrated use of by-products of the predecessor, green manure and «Bio-Hel» biofertilizer, at a dose of 3.0 l/ha. Thus, in the conditions of the Left-Bank Forest-Steppe of Ukraine, soybeans are most rationally grown in a short-term organic crop rotation: soybeans – spring wheat – common millet with complex application of organic fertilizers.
Growth of leaf area and yield of winter rape hybrids in the conditions of the northeastern part of the western Forest-Steppe
Authors: Hoisiuk Yu.V. , Hoisiuk S.O.
Published: July 2024

Розробити рекомендації щодо вирощування ріпаку озимого для господарств північно-східної частини Лісостепу Західного, а саме: серед групи класичних гібридів ріпаку озимого встановити ті, що забезпечують найбільшу урожайність, яка формується при конкретному способі сівби та нормі висіву насіння. Методи. Дослідження, з поставлених завдань, технології вирощування ріпаку озимого виконувались шляхом закладання польового досліду відповідно до загальноприйнятої методики за трьохфакторною схемою в чотириразовому повторенні. Дослід закладався на темно-сірих опідзолених ґрунтах, які є характерною ґрунтовою відміною для зазначеного регіону. Серед досліджуваних чинників були гібриди: ДК Екзодус, ДК Ексквізіт, ДК Експріт. Гібриди висівали із шириною міжрядь 15 см та 35 см і нормами висіву 350 і 450 тис./га. Результати. Визначено рівень урожайності в досліді, і як наслідок, встановлено, що найвищі показники були досягнуті, у досліджуваних гібридів ріпаку озимого, на варіантах із висіванням насіння шириною міжряддя 15 см. А саме, відповідно до гібриду та норми висіву насіння урожайність коливалася в межах 4,29–4,65 т/га. Найвищий показник 4,65 т/га був встановлений за висівання гібриду ДК Екзодус нормою висіву 450 тис./га. Висновки. В умовах північно-східної частини Лісостепу Західного для одержання найбільш підвищеної урожайності, рекомендовано висівати гібрид ріпаку озимого ДК Екзодус із нормою висіву насіння 450 тис./га та з міжряддям 15 см. А за необхідності висівання насіння із шириною міжряддя 35 см рекомендовано висівати гібрид ДК Ексквізіт із нормою висіву насіння 350 тис./га.
Common yarrow as a natural animal growth stimulator
Authors: Shtakal  M.I. , Holyk L.M. , Shtakal V.M. , Levchenko O.S. , Hlushchenko L.A.
Published: July 2024

To establish the biological features of the growth and development of common yarrow, its productivity and chemical composition and technological suitability for use as components of phytomixtures for the purpose of forming organic feed additives for animal feeding. Methods. Field, laboratory, variational statistics. Results. Research has established that common yarrow is technologically suitable for harvesting raw materials for medicinal and fodder purposes. Its yield of green mass for four years of research was 11.5 t/ha, and the yield of dry mass, respectively, was 2.8 t/ha. The raw protein content of yarrow was on average 15.9% and according to this indicator is equal to the protein content in leguminous grass species. It contains a sufficient amount of nutrients inherent in fodder. The above-ground mass of common yarrow contains up to 3.1% of essential oil and other components of biologically active substances. Conclusions. Yarrow is a natural stimulator of animal growth, having a high yield, technologically suitable for harvesting raw materials and forming phytomixtures in feeding agricultural animals. Its biologically active substances are essential oils, flavonoids, vitamins, tannins.
Variation of spring barley’s quantitative traits of samples in the conditions of the central Forest-Steppe of Ukraine
Authors: Novak Zh.M. , Nenka O.V.
Published: July 2024

The aim of the research was to determine the level of quantitative traits (number of spikelet and grains per ear, weight of 1000 grains) of spring barley breeding material, to determine genotypic and environmental variance as components of the overall phenotypic and degree of genetic and environmental variation. Methods. During six years (2018-2023) we observed four varieties and 12 breeding numbers of spring barley. Based on the results obtained, the coefficient of variation was determined separately for each genotype and each year using the Excel program. The seeding rate of spring barley seeds in the experiment was 4 million per ha. The registered area of the plot was 4.00 m2. Results. The average number of spikelet in an ear in the analyzed material was 19.8-23.0 pcs. This indicator varied by genotype on average in 2018 and 2023, in 2019, 2020, 2021 and 2022 - slightly. Depending of the year, the indicators varied significantly for all biotypes. The average environmental variance was 32.7%, which was eight times higher than the average genotypic variance (4.4%). The total phenotypic variance was 37.1%. The average number of grains per ear ranged from 13.0 to 17.0. The coefficient of variation due to differences in the years of research was medium and significant. At the same time, the average environmental variance was 11.2%, varying in different biotypes from 3.9% in variety 7/23 to 24.7% in selection number 15/23. The genotypic variance averaged 8.7%, and the total phenotypic variance was 19.9%. The number of grains per ear by genotype varied significantly in 2018, 2020 and 2021, and was average in 2019, 2022 and 2023. The weight of 1000 grains was on average 40.2-52.6 g. It varied moderately depending on the genotype in 2018, 2019, and 2023, and slightly in 2020, 2021, and 2022. Depending on the year`s conditions, the weight of 1000 grains varied slightly and moderately. Conclusions. The number of spikelet per ear is determined by growing conditions rather than genotype. The variation of the number of grains per ear depending on environmental conditions and genotype was medium to significant. The weight of 1000 grains varied moderately and slightly depending on the genotype and the year’s conditions.
Tüzel Kişilik Perdesinin Kaldırılabileceği Hâllerin Tek Ortaklı Şirketlerdeki Görünümü
Authors: Çataklı Celile Çağla
Published: July 2024

Sermaye şirketlerinde ortakların sınırlı sorumluluğu ve tüzel kişiliğin getirdiği ayrılık ilkesi, şirketi oluşturan ortaklar tarafından kötüye kullanılabilmektedir. Dürüstlük kuralına aykırılık oluşturan bu gibi durumlarda tüzel kişiyi oluşturan ortakların sorumluluğuna gidilebilmesi için uygulamada tüzel kişilik perdesinin kaldırılması yolu ortaya çıkmıştır. İstisnai olarak uygulanan bu yolun söz konusu olabileceği hâller gerek yabancı öğretide gerekse Türk öğretisinde incelenmiştir. Ülkemizde öğretide ve yargı kararlarında öz kaynak yetersizliği, malvarlıklarının veya alanların birbirine karışması ve yabancı yönetim olmak üzere başlıca üç sebep üzerinde durulmaktadır. Bununla birlikte 6102 sayılı Türk Ticaret Kanunu’nun (TTK) yürürlüğe girmesiyle beraber ticari hayatta yaygınlaşmaya başlayan tek ortaklı sermaye şirketlerinde tüzel kişilik perdesinin kaldırılması konusu ayrı bir öneme sahip olmuştur. Çalışmamızda tüzel kişilik perdesinin kaldırılmasının söz konusu olabileceği üç hâl tek ortaklı şirketler çerçevesinde incelenmiştir.
ASSISTÊNCIA EM PRIMEIROS SOCORROS AOS BENEFICIÁRIOS MIGRANTES DENTRO DA OPERAÇÃO ACOLHIDA: PERCEPÇÕES DOS ENFERMEIROS DA CRUZ VERMELHA BRASILEIRA AMAZONAS ATUANTES NO DEPARTAMENTO DE PRIMEIROS SOCORROS E ENSINO – RELATO DE EXPERIÊNCIA
Authors: Sousa Amanda Thyanne Sales de , Oliveira Leticia Marcelly Lima de , Nascimento Rayssa Toga Cambriai
Published: July 2024

INTRODUÇÃO: Assistência em primeiros socorros são ações prestadas por profissionais ou pessoas capacitadas em situações de emergência com intuito de prevenir lesões e proporcionar bem-estar a vítima até o momento da chegada da equipe especializada. OBJETIVO: Relatar as percepções dos enfermeiros voluntários acerca da assistência em primeiros socorros aos beneficiários dentro da Operação Acolhida. METODOLOGIA: Trata-se de estudo exploratório-descritivo do tipo relato de experiência com auxílio de referências que embasam a pesquisa. RESULTADO E DISCUSSÃO: O relato de experiência em primeiros socorros visa a importância do trabalho voluntário e os desafios enfrentados pela equipe frente a assistência e ainda sim desencadear percepções positivas ao prestar o serviço. CONCLUSÃO: Assistência em primeiros socorros desencadeia práticas realizadas em situações de urgência e emergência e busca estabelecer bem-estar a vítima até a chegada do serviço especializado. Mesmo diante de barreiras enfrentadas pela equipe, consegue-se obter resultados satisfatórios acerca da prestação de serviços e estimula o espírito humanitário do voluntário por meio de dedicação e colaboração enquanto desenvolve condutas de enfermagem ao beneficiário.
Rare earth element proxy for distinguishing marine versus freshwater Ediacaran fossils
Authors: Retallack Gregory
Published: July 2024

Ediacaran fossils and sedimentary rocks are controversial for whether they are marine or non-marine, and this study applies the test of light rare earth over heavy rare earth weight ratios (LYREE/HYREE) to a variety of Ediacaran siliciclastic and carbonate fossil matrices. Holocene soils have light-YREE-enriched arrays (LYREE/HYREE>4.8) and modern deep marine clays have heavy-YREE-enriched arrays (LYREE/HYREE<2.7). Flat arrays of fluvial and shallow marine siliciclastic sediments (LYREE/HYREE 2.7-4.8) are indistinguishable by this proxy. This proxy has been applied to a variety of Ediacaran and Cambrian rocks, for which confounding provenance effects were minimized by comparing marine and non-marine pairs within the same formations. Many samples were within the ambiguous zone (LYREE/HYREE 2.7-4.8), but Ediacaran red beds from Newfoundland, and some beds from China, Namibia, central and South Australia showed diagnostic continental, terrestrial LYREE/HYREE weight ratios of 4.8 to 11.3. A grey tempestite from Newfoundland, a grey sandstone from California, and grey dolostones from Australia and Namibia showed marine LYREE/HYREE weight ratios of 2.7 or less, from the same provenance as terrestrial samples. This new criterion for distinguishing marine from non-marine Ediacaran rocks is supported also by boron content, Ge/Si ratios, and eolian interbeds. Furthermore, new analyses correctly interpreted trilobite and Cloudina beds as marine. One surprisingly secure result is that fossiliferous Ediacaran rocks of Newfoundland were not formed in a deep ocean, but on coastal plains. Some fossiliferous Newfoundland beds have LYREE/HYREE weight ratios of as much as 6.0-11.3, found only in paleosols.
FEATURES, DYNAMICS AND PROSPECTS OF PREFERENTIAL MORTGAGE LENDING IN RUSSIA
Authors: Sheyhova Marina , Safonova Svetlana
Published: July 2024

Mortgage lending in modern conditions is one of the important tools used to solve the acute housing issue. The article examines the modern mortgage (housing) lending market. The current statistical data on the mortgage market, the volume and number of mortgage loans issued, and mortgage interest rates are provided.
The dependence between the dynamics of changes in the key rate of the Central Bank of the Russian Federation from 2019 to 2023 and the volume of mortgage lending is investigated. The data on the average cost of 1 sq. m. are given. m in the housing market by federal districts of the Russian Federation in dynamics.
The main features of the mortgage lending market in Russia are highlighted. The key changes in the mortgage lending market this year and the prospects for the development of the mortgage lending market are considered.
Asuhan Keperawatan pada Ny. S dengan Diagnosa Stroke Infark
Authors: Lestari Inka , Efendi Ramli , Tri Noviyani Arina , Alfi Lail Nur , Ahmad Fausi Adhin
Published: July 2024

Stroke terjadi akibat Penyumbatan atau pendarahan yang terjadi pada otak, hal ini  menyebabkan  gangguan fungsi otak secara mendadak  yang mengakibatkan aliran darah dan oksigen ke otak terganggu. Sehingga terjadi kematian jaringan otak yang mengakibatkan penderitanya mengalami kelumpuhan hingga kematian. World Health Organisation (WHO) menyebutkan angka kematian akibat stroke sebesar 51% diseluruh dunia disebabkan oleh tekanan darah tinggi pernyataan ini berasal dari laporan WHO pada tahun 2013 yang menguraikan beban penyakit global yang disebabkan oleh hipertensi? (Merck Group)?. Tujuan dari penelitian ini untuk memberikan gambaran pelaksanaan Asuhan Keperawatan Pada pasien dengan diagnosa stroke infrak diruang Stroke Unit RSUD Gunung Jati Kota Cirebon. Metode yang digunakan yaitu pendekatan studi kasus. Subjek dalam studi kasus ini satu pasien dengan diagnosis medis stroke infrak di ruang rawat inap Stroke Unit. Hasil studi kasus dari penelolaan asuhan keperawatan pasien dengan diagnosis medis stroke infrak dengan masalah keperawatan gangguan mobilitas fisik, setelah diberikan intervensi ROM pada ekstermitas kiri selama 3 hari, didapat kan hasil ekestermitas kiri mulai dapat di gerakan dari semula kekuatan otot 1 menjadi 3. Dari hasil intervensi yang telah dilakukan dapat disimpulkan bahwa penerapan ROM pada pasien stroke efektif untuk meningkatkan kekuatan otot ekstermitas pada pasien stroke, penerapan tehknik non farmakologis seperti ROM dapat di jadikan sebegai pendampin terapi farmakologis.
Edukasi dan Pendampingan Pemilihan Bahan Makanan untuk Imunitas Tubuh bagi Guru dan Orang Tua Murid TK Anggrek Palembang
Authors: Siregar Afriyana , Hartati Yuli , Podojoyo Podojoyo , Telisa Imelda
Published: July 2024

Coronavirus Disease 2019 (COVID-19) saat ini merupakan penyakit yang sangat meresahkan masyarakat. Tanda dan gejala umum infeksi COVID-19 antara lain gejala gangguan pernapasan akut seperti demam, batuk dan sesak napas. COVID-19 dapat menular dari manusia ke manusia melalui kontak erat dan droplet, tidak melalui udara. Orang yang paling berisiko tertular penyakit ini adalah orang yang kontak erat dengan pasien COVID-19 termasuk yang merawat pasien COVID-19. Rekomendasi standar untuk mencegah penyebaran infeksi adalah melalui cuci tangan secara teratur, menerapkan etika batuk dan bersin, menghindari  kontak secara langsung dengan ternak dan hewan liar serta menghindari kontak dekat dengan siapa pun yang menunjukkan gejala penyakit pernapasan seperti batuk dan bersin. Anak-Anak, orang tua dan orang yang mempunyai penyakit kurmobid merupakan kelompok yang rentan terhadap penyakit yang diakibatkan covid 19.  Selama terjadinya pandemi Covid 19 imunitas tubuh harus benar-benar terjaga untuk mencegah tubuh terserang virus corona tersebut. Agar imunitas tubuh meningkat dibutuhkan pengetahuan dalam memilih bahan makanan yang benar terutama bagi guru dan orang tua. Tujuan kegiatan pengabdian masyarakat ini untuk meningkatkan pengetahuan guru dan orang tua murid dalam memilih bahan makanan untuk meningkatkan imunitas tubuh selama covid 19. Metode yang digunakan dengan penyuluhan dan pendampingan pemilihan bahan makanan untuk meningkatkan imunitas tubuh. Hasil kegiatan pengabdian masyarakat menunjukan adanya peningkatan pengetahuan guru dan orang tua murid setelah dilakukan pendampingan. Kesimpulan pendampingan dapat meningkatkan pengetahuan guru dan orang tua murid.
Study of the Simulation and Application of the PEEC Method for Modeling the Prediction of Emissions Radiated by the Onboard Electronic Wiring System
Authors: Nzao Anthony Bassesuka Sandoka
Published: July 2024

The coexistence of electronic power and control systems in the same box presents a serious threat to the proper functioning of electronic systems integrated into automobiles, aeronautics and space. Thus, managing the electromagnetic compatibility of these systems constitutes a challenge, particularly given electromagnetic phenomena. This paper describes a simulation study and application of the partial element equivalent circuit method to model the prediction of radiated emissions from the onboard electronic cable system. In this article, we first explain the use of the partial cell equivalent circuit modeling method, then describe its mathematical formulation and introduce the different electromagnetic phenomena it considers in connection with wiring, then propose radiation calculations electromagnetic as a function of the geometry of the discrete cells taking into account the increase in frequency. The goal is to get as close to the structure as possible. To balance the accuracy and speed of the proposed method, we replaced the partial capacities with the equivalent capacities so as to considerably minimize the number of capacities, the complexity of the system and the computational time requirement. This option adapts the partial element equivalent circuit method to the study of larger structures such as cable structures and provides an efficient and rapid way to simulate electromagnetic radiation. To achieve this objective, we have associated the physical laws of electromagnetic wave propagation with the method of modeling equivalent circuits using partial elements because it is easy to manipulate flat surfaces and cables. 2D simulations based on the proposed models were developed as well as the verification of the consistency of the different models, by comparing the fractal dimensions of the program results with those of the figures obtained experimentally.
Descartes’ın Özne Anlayışı Üzerine Bir Kritik
Authors: Yazğan Aydın
Published: July 2024

Bu çalışma Descartes’ın kurmuş olduğu epistemoloji bağlamında ortaya çıkan özneye etik ve hukuk bağlamında bir değerlendirme içermektedir. Descartes’ın insan tanımı cogito, akıl, matematiksel işlem yapabilme gibi yetiler söz konusu olduğunda şekillenmektedir. Bu bakımdan özne ve/veya insan tanımı ‘cogito ergo sum’ ekseninde oluşmaktadır. İnsanı sadece ratio yetisiyle tanımlamak ciddi birtakım etik, hukuksal sorunları gündeme getirmektedir. Örneğin insanın diğer varlıklardan ayıran belirgin özelliğin sadece düşünme olduğu varsayımı bu yetiden dezavantajlı durumda olan insanları bu tanımın dışında tutarken; bu yetiyi güçlü bir şekilde kullanan makineleri ise bu tanım kapsamına alabilmektedir. Dolayısıyla bu tanım, insanı bütünsel olarak ele almada yetersiz görünmektedir. Çünkü akılsal becerileri noksan olan insanlar bu açıklamaların dışında kaldığı için etik ve hukuk problemleri ortaya çıkmaktadır. Çalışma bağlamında Descartes’ın kendi özne anlayışını nasıl ortaya koyduğu irdelenmiş ve bu sistemden doğan insan tanımının etik ve hukuk söz konusu olduğunda ne derece geçerli olduğu tartışılmıştır.
Информационное обеспечение соответствующих структур системы социального управления.
Authors: Gahramanova Nigar
Published: July 2024

Суть управления или управленческой деятельности представляет собой целенаправленное воздействие на управляемую систему. Получение совершенно объективной информации в социально-экономической и политической сферах, о социальных системах – это достаточно сложное дело. Управление и информация неразрывно связаны. Особенно велико значение информации в управлении обществом, социальными процессами. Информация, используемая в управлении обществом, социальна по своей природе, она – социальная информация, поскольку формирующий и использующий ее человек, главный объект и субъект управления, является существом общественным, социальным в своей сущности, обязательно принадлежащим к тому или иному обществу, классу, нации, социальному коллективу. Информацию мы называем социальной на том основании, что она выражает и специфическим образом отражает отношения людей, их взаимодействия, потребности и интересы. Социальная информация является высшим, наиболее сложным и многообразным типом информации. Она используется в обществе – самой высокой форме движения материи. При ее помощи люди общаются между собой, обмениваются мыслями. Люди используют ее для целесообразного воздействия на общество, иначе говоря, в управлении обществом, которое является высшим типом управления.
Pengaruh Konseling Pendidikan terhadap Peningkatan Prestasi Akademik Siswa Slow Learner
Authors: Rizka Lailatul Qodaria  , Nova Estu Harsiwi
Published: July 2024

This research aims to analyze the effect of educational counseling on improving the academic achievement of slow learner students at the inclusive elementary school level. Students with special needs are slow learners often face significant challenges in learning that have a negative impact on their academic achievement. Through a personalized educational counseling approach, it is hoped that students can develop more effective learning strategies, as well as increase their motivation and self-confidence. This research uses a case study method with the subject of one slow learner student in an inclusive Labuhan 1 State Elementary School. Data was collected through observation, interviews and analysis of academic documents before and after the educational counseling intervention. The research results showed a significant increase in students' academic achievement after receiving intensive educational counseling. These findings indicate that personalized educational counseling can be an effective intervention in supporting the academic development of slow learner students in inclusive environments. The implication of this research is the need to implement special and focused educational counseling services in the inclusive education system to help slow learner students achieve their academic potential optimally.
Kemampuan Menulis Teks Persuasif pada Siswa Kelas IV di SDN 13 Limo Suku Kabupaten Agam
Authors: Dina Rahmadani  , Indah Irgandi  , Nur Hafizah  , Ranti Julia
Published: July 2024

This study aims to evaluate the ability to write persuasive texts in elementary school students. The main focus of the research is to analyze students' abilities in terms of text structure, linguistic rules, and characteristics of language use. The research method used is quantitative descriptive with the main instrument being a written test. The research subjects were four grade students at SDN 13 Limo Suku, Agam Regency. The research results show that: (1) In terms of text structure, the majority of students are able to write well, although some still experience difficulties in organizing arguments logically and coherently. (2) In terms of linguistic rules, students show a fairly good understanding, especially in the correct use of spelling and grammar, although there are some deficiencies in vocabulary variations and the use of complex sentences. (3) In terms of the characteristics of language use, students tend to be able to use persuasive language, but need more practice to improve rhetorical skills and the attractiveness of writing. Overall, the ability to write persuasive texts for fourth  grade elementary school students at SDN 13 Limo Suku, Agam Regency is in the quite capable category. These findings indicate the need for improvement in learning to write persuasive texts, with a focus on strengthening argument structures and using more varied and effective language. It is hoped that this research can become the basis for developing more effective learning strategies in improving students' persuasive writing skills at the elementary school level.
Penerapan Metode Demonstrasi untuk Meningkatkan Hasil Belajar PAI dan Budi Pekerti Peserta Didik Kelas 2 Sekolah Dasar
Authors: Moch Ilham Z. A.  , Ibnu Muthi
Published: July 2024

In the life of a Muslim, prayer is the most important part, as spiritual communication to Allah SWT at 5 times every day. The demonstration method allows students to understand the correct steps in performing prayer.  Student participation and motivation show positive changes. In the first cycle, the level of student participation increased to 70% during the demonstration process. Students show high interest and active involvement in learning activities. Students' learning motivation has also increased, as can be seen from their enthusiasm in participating in demonstrations and involvement in class discussions. In the second cycle, student participation increased further to 90%. Most students were active in practice and discussion sessions, indicating that this method was successful in creating an interactive and supportive learning environment. Apart from increasing the average score, student participation and motivation also showed positive changes. In the first cycle, the level of student participation increased to 70% during the demonstration process. Students show high interest and active involvement in learning activities. Students' learning motivation has also increased, as can be seen from their enthusiasm in participating in demonstrations and involvement in class discussions. In the second cycle, student participation increased further to 90%. Most students were active in practice and discussion sessions, indicating that this method was successful in creating an interactive and supportive learning environment.
Pengaruh Partisipasi Orang Tua dalam Proses Pembelajaran terhadap Prestasi Akademik Siswa Sekolah Dasar
Authors: Rizkia Nurul Wafa  , Ibnu Muthi
Published: July 2024

This study aims to investigate the impact of parental involvement in the learning process on the academic performance of elementary school students. The active and supportive participation of parents in their children's education has been proven to have a significantly positive effect on students' academic achievement. Research findings indicate that parental engagement in teaching and learning activities, both at home and at school, not only enhances students' motivation to learn but also contributes to improved performance in cognitive, psychomotor, and affective aspects. This involvement encompasses open communication, emotional support, and adequate provision of learning resources. Furthermore, effective collaboration between parents and teachers strengthens students' commitment to learning and achieving better academic outcomes. Other factors influencing students' academic performance include individual interest, motivation, and talent. Therefore, optimizing the role of parents in the educational process is crucial for attaining optimal academic performance at the elementary school level.
Memahami Strategi Pemasaran Online dalam Meningkatkan Keuntungan dengan Pengeluaran Efisien
Authors: Muhammad Dimas  , Muhammad Irwan Padli Nasution
Published: July 2024

In the rapidly developing digital era, online businesses face increasing challenges to achieve significant profits without sacrificing spending efficiency. To overcome this challenge, an optimal online marketing strategy is needed that can reach the right target market without significantly increasing operational costs. This journal discusses several online marketing strategies that are effective in increasing profits relevant to expenditure. From a deep understanding of the target market to the use of social media and careful data analysis, every step taken is based on the principles of efficiency and effectiveness. By implementing the right marketing strategies, businesses can increase their visibility online, attract more potential customers, and increase sales conversions without having to exceed their available budget. Thus, this journal provides practical guidance for business owners and marketers to achieve success in their online sales without sacrificing profitability.
Analisis Technology Acceptance Model (TAM) terhadap Penggunaan Fintech Peer To Peer (P2P) Lending sebagai Alternatif Pendanaan Modal Kerja UMKM Kuliner di Alun-alun Karanganyar
Authors: Debora Citra Kaloka  , Edi Wibowo
Published: July 2024

The study aims to determine how much (1) the effect of perceived ease of use on perceived usefulness in P2P Lending for culinary MSMEs in Karanganyar town square, (2) the effect of perceived ease of use on trust in P2P Lending for culinary MSMEs in Karanganyar town square, (3) the effect of perceived usefulness on trust in P2P Lending for culinary MSMEs in Karanganyar town square, (4) the effect of trust on attitude toward using in P2P Lending for culinary MSMEs in Karanganyar town square, and (5) the effect of attitude toward using on behavioral intention to use P2P Lending for culinary MSMEs in Karanganyar town square. This research uses Technology Acceptance Model (TAM) research methods with a sample of 75 respondents. Data analysis techniques using PLS SEM which consist of outer model and inner model. The outer model consists of convergent validity test, discriminat validity test, undimensionalitas test, and reliability test. The inner model uses R- square, Q square, path coefficient, Goodness of Fit, and descriptive analysis. The result showed that (1) perceived ease of use has a significant effect on perceived usefulness in P2P Lending for culinary MSMEs in Karanganyar town square, (2) perceived ease of use has a significant effect on trust in P2P Lending for culinary MSMEs in Karanganyar town square, (3) perceived usefulness has a significant effect on trust in P2P Lending for culinary MSMEs in Karanganyar town square, (4) trust has a significant effect attitude toward using in P2P Lending for culinary MSMEs in Karanganyar town square, (5) attitude toward using has a significant effect on behavioral intention to use P2P Lending for culinary MSMEs in Karanganyar town square.
Objectivity of Morality (Value)
Authors: Petrus CKL Bello
Published: July 2024

Ronald Dworkin refers to moral standards in law as legal principles. The inclusion of principles as inherent in law raises two problems. First, the problem of the objectivity of legal decisions: how to justify or account for a judge's decision based on moral values? Is a decision based on moral values right or wrong? If the decision is based on morality, then it is possible that the decision taken will be biased by the judge's own subjective judgment, then how to get objectivity? The issue of the objectivity of morality judgment occupies a central position in Dworkin's legal theory. He believes that there is one correct answer for almost all legal issues without having to refer to elements outside of himself (non-legal elements). If moral judgment is "subjective" then the thesis about one correct answer cannot be defended. Second, Dworkin's opinion that moral values are objective-which means that demands on these values are also objective-contains another problem, namely a moral dilemma resulting from a conflict between values. To answer this problem, Dworkin developed the notion of a unified value.