bluuebunny/crossref_metadata_2025 huggingface dataset:
Utility of Chinese Versions of Addenbrooke’s Cognitive Examination: A Narrative Review
Authors: Cao Ling-Xiao , Wang Gang , Guo Qi-Hao , Zhang Wei , Bak Thomas , Huang Yue
Published: October 2022

Addenbrooke’s cognitive examination (ACE) is a cognitive screening tool that has developed through three stages: ACE, ACE-Revised (ACE-R), and ACE-Ⅲ. In addition, mini-Addenbrooke’s Cognitive Examination (M-ACE) and ACE mobile are the additional versions that is derived from ACE-III. ACE and its related versions show better performance than Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in detecting mild cognitive impairment in different neurological disorders. It has been translated into numerous languages, including Chinese. Through reviewing the history, validity, and comparison with other cognitive tests of Chinese versions of ACE, it aims to facilitate the clinical and scientific use, further development, improvement, and validation of Chinese versions of ACE in various neurological disorders and ultimately promote early identification and management of cognitive impairment in China.
Methodology for Selecting the Appropriate Electric Motor for Robotic Modular Systems for Lower Extremities
Authors: Kavalieros Dimitrios , Kapothanasis Evangelos , Kakarountas Athanasios , Loukopoulos Thanasis
Published: October 2022

Torque calculation is essential for selecting the appropriate motor to achieve the required torque at each joint of a hybrid exoskeleton. In recent years, the combined use of functional electrical stimulation (FES) and robotic devices, called hybrid robotic rehabilitation systems, has emerged as a promising approach for the rehabilitating of lower limb motor functions. Specifically, the implementation strategy of functional electrical stimulation walking aid combined with the design of the exoskeleton part is the main focus of our research team. This work copes with issues of the design process of a robotic exoskeleton. The importance of robotic exoskeletons for providing walking aid to people with mobility disorders or the elderly is discussed. Furthermore, the approaches to calculating the joint torques are investigated, and the mathematical models and parameters of interest are identified. This further includes the comparative data for servo motors: robotic exoskeleton characteristics and actuator analysis in the robotic exoskeleton. The aforementioned is used to propose a mathematical model based on previous models (Zatsiorsky BSP and Dempster BSP body segment parameters models, forward kinematics models), which was extended to include added adjustable parameters such as length, area, volume, mass, density, the centre of mass, human body characteristics, and considering both static and dynamic parameter extraction. Then, an analytic method is presented, exploiting the results from the mathematical model to select the appropriate motor for each joint of the lower extremities. The detailed description of the method is followed by examples, experimental measurements, and statistical analysis of qualitative and quantitative characteristics. The results showed deviations from typical calculation methods, offering a better understanding of the motor requirements for each joint of the exoskeleton and avoiding selections of marginal functionality features of the motors. In addition, researchers are offered a tool for replicating the results of this work, allowing them to configure the parameters associated with the servo motor features. The researcher can either use the embedded library developed for this work or enter new data into it, affecting the calculated torques of the model joints. The extracted results assist the researcher in choosing the appropriate motor among commercially available brushed and brushless motors based on the torques applied at each joint in robotic articulated systems.
Is It Safe to Stay at Home? Parents’ Perceptions of Child Home Injuries during the COVID-19 Lockdown
Authors: Papachristou Eirini , Deftereos Savas , Oikonomou Panagoula , Bekiaridou Konstantina , Foutzitzi Soultana , Gogoulis Ioannis , Sinopidis Xenophon , Romanidis Konstantinos , Tsaroucha Alexandra , Kambouri Katerina
Published: October 2022

The COVID-19 pandemic and stay-at-home regulations have increased child home injuries. This study illustrates the type and frequency of child home injuries in Greece during the COVID-19 lockdown. Moreover, the survey reports the results on parents’ proposals regarding child injuries at home during the COVID-19 quarantine. A community-based, cross-sectional, descriptive study was conducted from November to December 2021 in Greece. Parents were asked to voluntarily complete an anonymous questionnaire, designed for the needs of the research. A statistical analysis of the data was performed using the Kolmogorov–Smirnov and Shapiro–Wilk tests for a normal distribution, a chi-squared (χ2) test to compare percentages among different groups and a non-parametric Mann–Whitney U test to determine the differences in Likert scale variables between two groups. A total of 130 parents with at least one child were questioned through an online questionnaire survey. Of the parents, 39.3%, stated that the number of accidents in their home increased. The most frequent accidents were injuries (49.3%). Most of the accidents occurred inside the house (75.8%) and were observed among children aged 0–4 years. A high percentage of children’s accidents was observed in rural/island areas or in the suburbs. Children who were with either their father or mother had one accident, and a higher number of accidents occurred when the children were with their grandparents, with the nanny or alone. For those parents who had difficulty supervising their child, child accidents increased compared to parents who had the ability to supervise. It was noticed that parents who knew how to provide a safe home stated that the number of accidents remained the same. Parents must organize a safer home. Authorities should educate parents on child injury prevention and provide them with financial facilities to provide a safer house.
Urban–Rural Distinction or Economic Segmentation: A Study on Fear and Inferiority in Poor Children’s Peer Relationships
Authors: Wang Shencheng , Liu Baochen , Yang Yongzheng , Yang Liangwei , Zhen Min
Published: October 2022

Peer relationships play an important role in the growth of children. This study offers insights about feelings of fear and inferiority in children’s peer relationships. Based on a national survey, the 2018 Construction for Social Policy Support System for Urban and Rural Poor Families in China, initiated by the Ministry of Civil Affairs, and using multiple regression models and a structural equation model, this study discusses whether and how having a rural household registration or being from a poor (dibao) family has an isolation effect on fear and inferiority in children’s peer relationships. The research findings indicate that children with a rural household registration or those from a dibao family are at a disadvantage in peer interactions. Moreover, rural resident identity has an indirect effect on children’s fear of peers and inferiority, mainly through psychological resilience, anxiety and depression, and mobile phone dependence. Being from a dibao family directly influences children’s fear and inferiority in their peer relationships; it also indirectly influences fear of peers and inferiority through psychological resilience. This study suggests that more attention should be paid to fear of peers and inferiority in rural children or children from a dibao family.
Elevated Levels of Toxic Bile Acids in Serum of Cystic Fibrosis Patients with CFTR Mutations Causing Pancreatic Insufficiency
Authors: Tabori Harold , Schneider Jochen , Lüth Stefan , Zagoya Carlos , Barucha Anton , Lehmann Thomas , Kauf Eberhard , Barth Astrid , Mainz Jochen G.
Published: October 2022

Hepatobiliary involvement is a hallmark in cystic fibrosis (CF), as the causative CF Transmembrane Conductance Regulator (CFTR) defect is expressed in the biliary tree. However, bile acid (BA) compositions in regard to pancreatic insufficiency, which is present at an early stage in about 85% of CF patients, have not been satisfactorily understood. We assess the pattern of serum BAs in people with CF (pwCF) without CFTR modulator therapy in regard to pancreatic insufficiency and the CFTR genotype. In 47 pwCF, 10 free and 12 taurine- and glycine-conjugated BAs in serum were prospectively assessed. Findings were related to genotype, pancreatic insufficiency prevalence (PIP)-score, and hepatic involvement indicated by serum liver enzymes, as well as clinical and ultrasound criteria for CF-related liver disease. Serum concentrations of total primary BAs and free cholic acid (CA) were significantly higher in pwCF with higher PIP-scores (p = 0.025, p = 0.009, respectively). Higher total BAs were seen in pwCF with PIP-scores ≥0.88 (p = 0.033) and with pancreatic insufficiency (p = 0.034). Free CA was higher in patients with CF-related liver involvement without cirrhosis, compared to pwCF without liver disease (2.3-fold, p = 0.036). pwCF with severe CFTR genotypes, as assessed by the PIP-score, reveals more toxic BA compositions in serum. Subsequent studies assessing changes in BA homeostasis during new highly effective CFTR-modulating therapies are of high interest.
Starvation Levels Affect Behaviors of Wild-Caught and Laboratory-Reared Oil Palm Pollinator Weevil, Elaeidobius kamerunicus (Coleoptera: Curculionidae)
Authors: Abd Latip Nurul Fatihah , Abd Ghani Idris , Hazmi Izfa Riza , Muhammad Nasir Dzulhelmi
Published: October 2022

The oil palm pollinating weevil, Elaeidobius kamerunicus Faust (Coleoptera: Curculionidae) was first introduced into Malaysia from Cameroon as the main oil palm pollinator in 1981. Since then, oil palm pollination has improved and the need for assisted pollination has reduced. However, their pollinating behavior may be influenced by starvation, sexes and sources (wild-caught and lab-reared). A study to determine the effect of starvation level, sexes and sources of E. kamerunicus on their diurnal behavior was conducted utilizing two hours of direct observation between 1130 and 1330 h. The frequency and the time spent for several diurnal behaviors on oil palm flowers were recorded and evaluated. Starvation prevented the weevils from conducting the activities because they probably had to focus more on searching for food to gain energy to perform other behavior. Wild-caught and lab-reared E. kamerunicus differed in their size, while sexes of E. kamerunicus significantly affect the diurnal behavior. However, an in-depth study is needed to determine the relationship between the diurnal behavior of E. kamerunicus and oil palm production.
Clinical and Radiologic Outcomes after Anatomical Total Shoulder Replacement Using a Modular Metal-Backed Glenoid after a Mean Follow-Up of 5.7 Years
Authors: Noschajew Emil , Rittenschober Felix , Kindermann Harald , Ortmaier Reinhold
Published: October 2022

Background: Glenoid wear is a common complication of anatomical total shoulder arthroplasty (aTSA) with a metal-backed glenoid (MBG), and the clinical and radiological results of historical implants are poor. The aim of this work was to evaluate the clinical and radiological results of 25 participants as well as the longevity after implantation of an anatomic shoulder prosthesis with a recent, modular cementless flat metal-backed glenoid component after a mean follow-up of 5.7 years. Methods: Clinically, the Simple Shoulder Test (SST), UCLA Activity Score (UCLA), and Constant Murley Score (CMS) were evaluated. Radiographically, the radiolucent lines (RLs), humeral head migration (HHM), and lateral glenohumeral offset (LGHO) were assessed. Survival was calculated with Kaplan–Meier curves and life-table analysis. Results: The mean CMS at follow-up was 46.2 points (range: 14–77; SD: 19.5). In terms of the SST score, the average value was 6.5 points (range: 1–10; SD: 3.5). The UCLA activity score showed a mean value of 5.9 points (range: 1–9; SD: 2.1). There were 17 revisions after a mean follow-up of 68.2 months (range: 1.8–119.6; SD: 27.9). HHM occurred in every patient, with a mean measurement of 6.4 mm (range: 0.5–13.4; SD: 3.9; p < 0.0001). The mean LGHO between the initial postoperative and follow-up images was 2.6 mm (range: 0–4.0; SD: 1.5; p < 0.0001). RLs were found in 22 patients (88%) around the glenoid and in 21 patients (84%) around the humeral head prosthesis. Conclusion: The clinical and radiographic outcomes after metal-backed glenoids were poor at 2.2 to 8.4 years of follow-up. We determined devastating survival in the majority of cases (68%), with mostly inlay wear (71%) as the main reason that led to revision surgery. The use of metalback genoids cannot be recommended based on the data of this study.
Admission Predictors of Mortality in Hospitalized COVID-19 Patients—A Serbian Cohort Study
Authors: Poskurica Mina , Stevanović Đorđe , Zdravković Vladimir , Čekerevac Ivan , Ćupurdija Vojislav , Zdravković Nebojša , Nikolić Tomislav , Marković Marina , Jovanović Marina , Popović Marija , Vesić Katarina , Azanjac Arsić Ana , Lazarević Snežana , Jevtović Andra , Patrnogić Aleksandar , Anđelković Marija , Petrović Marina
Published: October 2022

Background: Early prediction of COVID-19 patients’ mortality risk may be beneficial in adequate triage and risk assessment. Therefore, we aimed to single out the independent morality predictors of hospitalized COVID-19 patients among parameters available on hospital admission. Methods: An observational, retrospective–prospective cohort study was conducted on 703 consecutive COVID-19 patients hospitalized in the University Clinical Center Kragujevac between September and December 2021. Patients were followed during the hospitalization, and in-hospital mortality was observed as a primary end-point. Within 24 h of admission, patients were sampled for blood gas and laboratory analysis, including complete blood cell count, inflammation biomarkers and other biochemistry, coagulation parameters, and cardiac biomarkers. Socio-demographic and medical history data were obtained using patients’ medical records. Results: The overall prevalence of mortality was 28.4% (n = 199). After performing multiple regression analysis on 20 parameters, according to the initial univariate analysis, only four independent variables gave statistically significant contributions to the model: SaO2 < 88.5 % (aOR 3.075), IL-6 > 74.6 pg/mL (aOR 2.389), LDH > 804.5 U/L (aOR 2.069) and age > 69.5 years (aOR 1.786). The C-index of the predicted probability calculated using this multivariate logistic model was 0.740 (p < 0.001). Conclusions: Parameters available on hospital admission can be beneficial in predicting COVID-19 mortality.
Long-Term Outcomes after Pelvic Organ Prolapse Repair in Young Women
Authors: Lallemant Marine , Clermont-Hama Yasmine , Giraudet Géraldine , Rubod Chrystèle , Delplanque Sophie , Kerbage Yohan , Cosson Michel
Published: October 2022

The aim of the study was to describe the long-term outcomes of Pelvis Organ Prolapse (POP) repair in women under 40 years old. A retrospective chart review of all POP repairs performed in women ≤40 years old between January 1997 and December 2015 in the Gynecologic Surgery Department of Lille University Hospital was performed. Inclusion criteria were all women ≤40 years old who underwent a POP repair with a stage ≥2 POP according to the Baden and Walker classification. The study population was separated into three groups: a sacrohysteropexy group, a vaginal native tissue repair (NTR) group, and a transvaginal mesh surgery (VMS) group. The primary outcome was reoperation procedures for a symptomatic recurrent POP. Secondary outcomes were other complications. During the study period, 43 women ≤ 40 years old who underwent a POP repair were included and separated into three groups: 28 patients (68%), 8 patients (19%), and 7 patients (16%) in the sacrohysteropexy, VMS, and NTR groups respectively. The mean followup time was 83 ± 52 months. POP recurrence, reoperated or not, was essentially diagnosed in the VMS group (87.5%) and the NTR group (50%). POP recurrence repairs were performed for nine patients (21%): 7%, 62.5%, and 25% in the sacrohysteropexy, VMS, and NTR groups, respectively. Global reoperation concerned 10 patients (23%) whatever the type of POP surgery, mainly patients from the VMS group (75%) and from the NTR group (25%). It occurred in only 7% of patients from the sacrohysteropexy group. Two patients (4%) presented a vaginal exposure of the mesh (in the VMS group). De novo stress urinary incontinence was encountered by nine patients (21%): 29% and 12.5% in the sacrohysteropexy and NTR groups, respectively. Despite the risk of recurrence, POP repair should be proposed to young women in order to restore their quality of life. Vaginal native tissue repair or sacrohysteropexy should be performed after explaining to women the advantages and disadvantages of each procedure.
Non-Invasive Assessment of Right Ventricle to Arterial Coupling for Prognosis Stratification of Fibrotic Interstitial Lung Diseases
Authors: Santoro Ciro , Buonauro Agostino , Canora Angelo , Rea Gaetano , Canonico Mario , Esposito Roberta , Sanduzzi Zamparelli Alessandro , Esposito Giovanni , Bocchino Marialuisa
Published: October 2022

Background: The coupling of the right ventricle (RV) to the pulmonary circulation is an indicator of RV performance that can be non-invasively estimated by echocardiography. There are no data about its use in patients affected by fibrotic interstitial lung diseases (f-ILD). Methods: Fifty f-ILD patients, including 27 cases with idiopathic pulmonary fibrosis (IPF) (M = 37; mean age 67 ± 7 years), were studied with standard and speckle-tracking echocardiography and compared with 30 age-matched healthy volunteers. The mean patient follow-up was 70 ± 4 months. Results: Fibrotic ILD patients had a larger right ventricle (RV) and worse diastolic function because the RV global longitudinal strain (GLS) was significantly lower and the systolic pulmonary artery pressure (sPAP) estimates were higher in comparison with those of controls. Conversely, tricuspid annular systolic excursion (TAPSE) did not differ between controls and patients. Median values of TAPSE/sPAP and RV GLS/sPAP were significantly reduced in f-ILD patients (p < 0.0001). Patients with an RV GLS/sPAP below the median value had a shorter survival time (61 vs. 74 months, p = 0.01); this parameter was an independent predictor of a worse outcome. Conclusion: Low estimates of RV GLS/sPAP are predictive of worse outcomes in f-ILD patients. RV coupling seems to be a promising surrogate biomarker of RV performance to discriminate the patient phenotype with significant management and prognosis implications.
Long-Term Prognosis Value of Paravalvular Leak and Patient–Prosthesis Mismatch following Transcatheter Aortic Valve Implantation: Insight from the France-TAVI Registry
Authors: Deharo Pierre , Leroux Lionel , Theron Alexis , Ferrara Jérome , Vaillier Antoine , Jaussaud Nicolas , Porto Alizée , Morera Pierre , Gariboldi Vlad , Iung Bernard , Lefevre Thierry , Commeau Philippe , Gouysse Margaux , du Chayla Florence , Glatt Nicolas , Cayla Guillaume , Le Breton Herve , Benamer Hakim , Beurtheret Sylvain , Verhoye Jean Philippe , Eltchaninoff Helene , Gilard Martine , Collet Jean Philippe , Dumonteil Nicolas , Collart Frederic , Modine Thomas , Cuisset Thomas
Published: October 2022

Background: Transcatheter aortic valve implantation (TAVI) is the preferred treatment for symptomatic severe aortic stenosis (AS) in a majority of patients across all surgical risks. Patients and methods: Paravalvular leak (PVL) and patient–prosthesis mismatch (PPM) are two frequent complications of TAVI. Therefore, based on the large France-TAVI registry, we planned to report the incidence of both complications following TAVI, evaluate their respective risk factors, and study their respective impacts on long-term clinical outcomes, including mortality. Results: We identified 47,494 patients in the database who underwent a TAVI in France between 1 January 2010 and 31 December 2019. Within this population, 17,742 patients had information regarding PPM status (5138 with moderate-to-severe PPM, 29.0%) and 20,878 had information regarding PVL (4056 with PVL ≥ 2, 19.4%). After adjustment, the risk factors for PVL ≥ 2 were a lower body mass index (BMI), a high baseline mean aortic gradient, a higher body surface area, a lower ejection fraction, a smaller diameter of TAVI, and a self-expandable TAVI device, while for moderate-to-severe PPM we identified a younger age, a lower BMI, a larger body surface area, a low aortic annulus area, a low ejection fraction, and a smaller diameter TAVI device (OR 0.85; 95% CI, 0.83–0.86) as predictors. At 6.5 years, PVL ≥ 2 was an independent predictor of mortality and was associated with higher mortality risk. PPM was not associated with increased risk of mortality. Conclusions: Our analysis from the France-TAVI registry showed that both moderate-to-severe PPM and PVL ≥ 2 continue to be frequently observed after the TAVI procedure. Different risk factors, mostly related to the patient’s anatomy and TAVI device selection, for both complications have been identified. Only PVL ≥ 2 was associated with higher mortality during follow-up.
Blood Cerebrospinal Fluid Barrier Function Disturbance Can Be Followed by Amyloid-β Accumulation
Authors: Suzuki Yuji , Nakamura Yukimi , Igarashi Hironaka
Published: October 2022

Background: Elucidation of the mechanism of amyloid-β accumulation plays an important role in therapeutic strategies for Alzheimer’s disease (AD). The aim of this study is to elucidate the relationship between the function of the blood–cerebrospinal fluid barrier (BCSFB) and the clearance of amyloid-β (Aβ). Methods: Twenty-five normal older adult volunteers (60–81 years old) participated in this PET study for clarifying the relationship between interstitial water flow and Aβ accumulation. Water dynamics were analyzed using two indices in [15O]H2O PET, the influx ratio (IR) and drain rate (DR), and Aβ accumulation was assessed qualitatively by [18F]flutemetamol PET. Results: [15O]H2O PET examinations conducted initially and after 2 years showed no significant changes in both indices over the 2-year period (IR: 1.03 ± 0.21 and 1.02 ± 0.20, DR: 1.74 ± 0.43 and 1.67 ± 0.47, respectively). In [18F]flutemetamol PET, on the other hand, one of the 25 participants showed positive results and two showed positive changes after 2 years. In these three participants, the two indices of water dynamics showed low values at both periods (IR: 0.60 ± 0.15 and 0.60 ± 0.13, DR: 1.24 ± 0.12 and 1.11 ± 0.10). Conclusions: Our results indicated that BCSFB function disturbances could be followed by Aβ accumulation, because the reduced interstitial flow preceded amyloid accumulation in the positive-change subjects, and amyloid accumulation was not observed in the older adults with sufficiently high values for the two indices. We believe that further elucidation of interstitial water flow will be the key to developing therapeutic strategies for AD, especially with regard to prevention.
Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta
Authors: Gorodkov Alexander Yu. , Tsygankov Yuriy M. , Shepelev Alexey D. , Krasheninnikov Sergey V. , Zhorzholiani Shota T. , Agafonov Andrey V. , Mamagulashvili Vissarion G. , Savinov Dmitriy V. , Tenchurin Timur Kh. , Chvalun Sergey N.
Published: October 2022

A significant drawback of the rigid synthetic vascular prostheses used in the clinic is the mechanical mismatch between the implant and the prosthetic vessel. When placing prostheses with radial elasticity, in which this deficiency is compensated, the integration of the graft occurs more favorably, so that signs of cell differentiation appear in the prosthesis capsule, which contributes to the restoration of vascular tone and the possibility of vasomotor reactions. Aortic prostheses fabricated by electrospinning from a blend of copolymers of vinylidene fluoride with hexafluoropropylene (VDF/HFP) had a biomechanical behavior comparable to the native aorta. In the present study, to ensure mechanical stability in the conditions of a living organism, the fabricated blood vessel prostheses (BVP) were cross-linked with γ-radiation. An optimal absorbed dose of 0.3 MGy was determined. The obtained samples were implanted into the infrarenal aorta of laboratory animals—Landrace pigs. Histological studies have shown that the connective capsule that forms around the prosthesis has signs of high tissue organization. This is evidenced by the cells of the fibroblast series located in layers oriented along and across the prosthesis, similar to the orientation of cells in a biological arterial vessel.
Challenges to Student Interdisciplinary Learning Effectiveness: An Empirical Case Study
Authors: Xu Cong , Wu Chih-Fu , Xu Dan-Dan , Lu Wen-Qian , Wang Kai-Yi
Published: October 2022

In order to meet industrial demands, some colleges and universities have offered interdisciplinary programs that integrate design, engineering, and business. However, how many changes these programs have brought to students, and whether students participating in these programs have had better interdisciplinary ability than students involved in a single discipline study have always been questions that many researchers want to explore. In a university that offers an interdisciplinary program, we found that there is no significant difference in interdisciplinary integration ability between the students participating in the interdisciplinary program and the students involved in a single discipline study through quantitative comparisons of 91 student questionnaires and analyses of interviews with nine teachers of interdisciplinary courses and other related staff members. This may result from the students’ lack of motivation, lack of prior experience, the influence of individual traits, the increase of learning pressure and academic burden, and the interference of disciplinary factors during interdisciplinary learning. The research finding is intended to improve student interdisciplinary learning effectiveness by facilitating interdisciplinary teachers’ understanding of the influencing factors of student interdisciplinary learning, and by providing a reference for interdisciplinary teaching design.
Templatized Fused Vector Floating-Point Dot Product for High-Level Synthesis
Authors: Filippas Dionysios , Nicopoulos Chrysostomos , Dimitrakopoulos Giorgos
Published: October 2022

Machine-learning accelerators rely on floating-point matrix and vector multiplication kernels. To reduce their cost, customized many-term fused architectures are preferred, which improve the latency, power, and area of the designs. In this work, we design a parameterized fused many-term floating-point dot product architecture that is ready for high-level synthesis. In this way, we can exploit the efficiency offered by a well-structured fused dot-product architecture and the freedom offered by high-level synthesis in tuning the design’s pipeline to the selected floating-point format and architectural constraints. When compared with optimized dot-product units implemented directly in RTL, the proposed design offers lower-latency implementations under the same clock frequency with marginal area savings. This result holds for a variety of floating-point formats, including standard and reduced-precision representations.
Underwater Image Enhancement Based on Color Correction and Detail Enhancement
Authors: Wu Zeju , Ji Yang , Song Lijun , Sun Jianyuan
Published: October 2022

To solve the problems of underwater image color deviation, low contrast, and blurred details, an algorithm based on color correction and detail enhancement is proposed. First, the improved nonlocal means denoising algorithm is used to denoise the underwater image. The combination of Gaussian weighted spatial distance and Gaussian weighted Euclidean distance is used as the index of nonlocal means denoising algorithm to measure the similarity of structural blocks. The improved algorithm can retain more edge features and texture information while maintaining noise reduction ability. Then, the improved U-Net is used for color correction. Introducing residual structure and attention mechanism into U-Net can effectively enhance feature extraction ability and prevent network degradation. Finally, a sharpening algorithm based on maximum a posteriori is proposed to enhance the image after color correction, which can increase the detailed information of the image without expanding the noise. The experimental results show that the proposed algorithm has a remarkable effect on underwater image enhancement.
Study on the Performance of an Electric-Field-Enhanced Oil–Water Separator in Treating Heavy Oil with High Water Cut
Authors: Huang Songtao , He Xue , Chen Jiaqing , Wang Xiujun , Zhang Jian , Dong Jianyu , Zhang Baosheng
Published: October 2022

As most offshore oilfields come to the middle- and late-exploitation period, and with the popularization of tertiary enhanced oil recovery (EOR) technology, the physical properties of produced fluids become more complex, bringing new challenges to oil-water separation. Conventional solutions, such as increasing the input of chemicals, enlarging the volume of the separator equipment, and extending the processing, are usually uneconomical and space-wasting. Electric-field-enhanced oil-water separation equipment was developed in this paper, and a mine field test was carried out. With the average water cut of different sampling ports and the overall dehydration rate taken as indicators, the effects of electric field frequency, inlet flow, chemical type, and addition upon the separation of the device were evaluated. The experimental results showed that for the ABJ mixed liquid, the optimal operating frequency of the electric field is above 3500 Hz. Compared with traditional separation equipment, the advantages of the electric-field-enhanced oil–water separation equipment are more significant in large flow conditions. When the water cut of the platform inlet fluctuates between 78% and 97%, and without the addition of chemicals, the average water cut was reduced to 7% and the average dehydration rate reached 90%, an improvement of about 15%.
Is the CYP2D6 Genotype Associated with Antipsychotic-Induced Weight Gain?
Authors: Jürgens Gesche , Kaas-Hansen Benjamin Skov , Nordentoft Merete , Werge Thomas , Andersen Stig Ejdrup
Published: October 2022

Antipsychotic-induced weight gain (AIWG) is a serious adverse effect. Studies have linked genetically-predicted CYP2D6 metabolic capacity to AIWG. The evidence, however, is ambiguous. We performed multiple regression analyses examining the association between genetic-predicted CYP2D6 metabolic capacity and AIWG. Analyses were based on previously unpublished data from an RCT investigating the clinical utility of routine genotyping of CYP2D6 and CYP2C19 in patients with schizophrenia. A total of 211 patients, corresponding to 71% of the original study population, were included. Our analyses indicated an effect of genetically predicted CYP2D6 metabolic capacity on AIWG with significant weight gain in both CYP2D6 poor metabolizers (PMs) (4.00 kg (95% CI: 0.80; 7.21)) and ultrarapid metabolizers (UMs) (6.50 kg (95% CI: 1.03; 12.0)). This finding remained stable after adjustment for covariates (PMs: 4.26 kg (0.88; 7.64), UMs: 7.26 kg (1.24; 13.3)). In addition to the CYP2D6 metabolic capacity, both baseline body mass index (−0.24 (95% CI: −0.44; −0.03)) and chlorpromazine equivalents per day (0.0041 (95% CI: 0.0005; 0.0077)) were statistically significantly associated with weight change in the adjusted analysis. Our results support that the genetically predicted CYP2D6 metabolic capacity matters for AIWG.
Climate Change Adaption between Governance and Government—Collaborative Arrangements in the City of Munich
Authors: Linke Simone , Erlwein Sabrina , van Lierop Martina , Fakirova Elizaveta , Pauleit Stephan , Lang Werner
Published: October 2022

Growing cities face severe land use conflicts. Urban expansion and the densification of existing built areas are increasing the pressure on green spaces, which are key for climate change adaptation. Planning procedures embroiled in these land use conflicts are often complicated and slow. This is due to the increasing complexity in planning processes, which involve a multitude of stakeholders and decision-makers, whose responsibilities are not always entirely clear. Governance-oriented forms of decision making with horizontal structures are often required, but these also entail challenges. In our study, we ask how climate adaptation through urban green spaces can be integrated into planning processes. The study is based on a methodological combination, including document analysis and qualitative interviews with administrative staff. The City of Munich, a rapidly growing German city, serves as a case study. The results show different collaborative arrangements in four planning arenas and demonstrate how these structures support or hinder climate change adaptation mainstreaming. We conclude that hierarchical structures impede horizontal collaborative arrangements and shed lights on mechanisms reinforcing these structures. For large administrations, informal meetings and coordinating units are effective in fostering interdepartmental cooperation.
Spatiotemporal Analysis of Urban Green Spatial Vitality and the Corresponding Influencing Factors: A Case Study of Chengdu, China
Authors: Dong Qidi , Cai Jun , Chen Shuo , He Pengman , Chen Xuli
Published: October 2022

Green space integrates diversified urban functions, and the analysis of its utilization, can help improve the vitality of the social and economic development of cities while contributing to the important goal of enhancing urban green space (UGS) planning and management. In this study, the heat value obtained from Baidu heat maps was used as an external representation of spatial vitality, and the factors that influence vitality were analyzed from two dimensions, i.e., the inner and outer space characteristics of green space, using spatial big data such as points of interest (POIs), Open Street Map (OSM) and online review data. The findings indicated that green space and urban resources in Chengdu are highly centralized. That is, a high road network density and nearby transportation facilities make it easier for visitors to reach parks, while peripheral functional density also plays a role in promoting vitality; additionally, reasonable and moderate space and functional layouts are conducive to the development of green space. In addition, our study integrates the tour experience index, which has a strong positive impact on vitality, to better reflect the human-oriented characteristics of green space, which are of great relevance to the construction and renewal of human space in UGSs.
The Willingness and Technology Preferences of Farmers and Their Influencing Factors for Soil Remediation
Authors: Yan Yunxian , Wang Lingqing , Yang Jun
Published: October 2022

Farmers are one of the major uncertainty factors in remediation of contamination farmland. Based on the face-to-face questionnaire survey data of 553 farmers in 4 heavy metal-contaminated agricultural soil remediation projects in China, this study used methods, such as structural equation modeling and random forest to explore farmers’ willingness to remediate, technology preference, and their key influencing factors for the first time. The results showed that farmers were willing to remediate contaminated soil and preferred phytoremediation, with 82.8% choosing phytoremediation, 12.5% choosing passivation, and 4.7% believing that the soil did not need to be remediated. In terms of willingness to remediate, the perceived benefits from participation in current remediation projects directly contributed to future willingness, with participation status (total impact coefficient 0.86) and perceived benefits (impact coefficient 0.49) being the main factors positively influencing farmers’ willingness. With regard to technology preference, technical characteristics (soil quality, 17.1%; secondary contamination, 16.8%; and remediation period, 11.5%) were the main influencing factors. The sustainability of passivation effect and the possible secondary contamination restrict the promotion of passivation, whereas the cessation of agricultural production during the long remediation period restricts the promotion of phytoremediation. It is recommended to increase farmers’ willingness to remediate by improving their perceived benefits and continuously overcoming the technical barriers by: (i) developing efficient and green passivators; and (ii) improving the efficiency of phytoremediation as well as intercropping or rotating cash crops while remediating. The results have important reference value for soil remediation in agricultural countries with small arable land per capita.
Reconstruction of Rural Settlement Patterns in China: The Role of Land Consolidation
Authors: Cui Jichang , Qu Yanbo , Li Yan , Zhan Lingyun , Guo Guancheng , Dong Xiaozhen
Published: October 2022

Taking the supplement of the quantity and quality of cultivated land in rural settlements as the departure point, this paper discusses the spatial and temporal integration reconstruction method of rural settlements. The disorderly expansion of residential areas in Pinggu District, Beijing, China has led to the erosion of high-quality cultivated land in the region and the advantages of mountain resources have not been fully utilized in this area. Therefore, Pinggu District was selected as the research area. Using the spatial analysis function in GIS, this paper uses the comprehensive correction method of the per capita construction land standard and the neighborhood substitution method to analyze the quantitative potential of rural settlements to supplement cultivated land and the qualitative grade of cultivated land after arrangement. A combination of exclusion matrices are employed to identify the spatial and temporal arrangements of rural settlements. The research shows that the effective cultivated land area of rural settlements in Pinggu District is 514.24 ha, and the coefficient of increasing cultivated land is 9.25%. Rural residential areas in the district are divided into priority sorting area, key sorting area, moderate sorting area, and restricted sorting area; they account for 18.13%, 21.10%, 20.85%, and 39.93% of the total area, respectively. According to the regional characteristics and dominant factor of the different consolidation areas, corresponding consolidation goals, models, and engineering measures are proposed to enrich the theory and approach to village planning and to provide a reference for practitioners engaged in regional rural land consolidation. The innovation of this study is putting forward the consolidation objectives, models and engineering measures based on the regional characteristics and leading factors of different land consolidation areas. This study has reference significance for the formulation and implementation of regional rural settlements consolidation planning and the policy of increasing and decreasing urban and rural construction land.
The Conserved Family of the Pyridoxal Phosphate-Binding Protein (PLPBP) and Its Cyanobacterial Paradigm PipY
Authors: Tremiño Lorena , Llop Antonio , Rubio Vicente , Contreras Asunción
Published: October 2022

The PLPBP family of pyridoxal phosphate-binding proteins has a high degree of sequence conservation and is represented in all three domains of life. PLPBP members, of which a few representatives have been studied in different contexts, are single-domain proteins with no known enzymatic activity that exhibit the fold type III of PLP-holoenzymes, consisting in an α/β barrel (TIM-barrel), where the PLP cofactor is solvent-exposed. Despite the constant presence of cofactor PLP (a key catalytic element in PLP enzymes), PLPBP family members appear to have purely regulatory functions affecting the homeostasis of vitamin B6 vitamers and amino/keto acids. Perturbation of these metabolites and pleiotropic phenotypes have been reported in bacteria and zebrafish after PLPBP gene inactivation as well as in patients with vitamin B6-dependent epilepsy that results from loss-of-function mutations at the PLPBP. Here, we review information gathered from diverse studies and biological systems, emphasizing the structural and functional conservation of the PLPBP members and discussing the informative nature of model systems and experimental approaches. In this context, the relatively high level of structural and functional characterization of PipY from Synechococcus elongatus PCC 7942 provides a unique opportunity to investigate the PLPBP roles in the context of a signaling pathway conserved in cyanobacteria.
Shear Bond Performance at Interface of Concrete-Filled Steel Tube after Freeze–Thaw Cycles
Authors: Xu Bo , Liu Yongjian
Published: October 2022

The shear bond performance between steel tube and concrete is the basis of a synergistic effect between two materials. When a concrete-filled steel tube structure is damaged by freeze and thaw cycles, the shear bond performance will deteriorate, which will inevitably affect the safety of the structure. In this paper, the effects of the numbers of freeze–thaw cycles, section type of steel tube, and concrete strength on the failure mode, bond strength, and peak slip of concrete-filled steel tube are investigated. In addition, the load–slip curve, the shear bond strength calculation formula, and the peak slip calculation formula are obtained. The results show that the shear bond performance decreases with the increase in freeze and thaw cycles; after 20 freeze and thaw cycles, the shear bond strength of the round steel tube specimen with 30 MPa decreases by 33.33%, while that of peak slip increases by 11.49%; the shear bond strength increases with the increase in concrete strength, while the degree of decrease in shear bond strength after freeze–thaw cycles is reduced; the shear bond strength of the round steel tube push-out specimen is higher than that of square steel tube push-out specimen, and after 20 freeze and thaw cycles, the shear bond strength of the round steel tube push-out specimen with 30 MPa/45 MPa is 0.86 MPa/1.62 MPa, while that of square steel tube push-out specimen with 30 MPa/45 MPa is 0.40 MPa/0.50 MPa.
Modelling and Simulation Strategies for Fluid–Structure-Interactions of Highly Viscous Thermoplastic Melt and Single Fibres—A Numerical Study
Authors: Gröger Benjamin , Wang Jingjing , Bätzel Tim , Hornig Andreas , Gude Maik
Published: October 2022

A virtual test setup for investigating single fibres in a transverse shear flow based on a parallel-plate rheometer is presented. The investigations are carried out to verify a numerical representation of the fluid–structure interaction (FSI), where Arbitrary Lagrangian–Eulerian (ALE) and computational fluid dynamics (CFD) methods are used and evaluated. Both are suitable to simulate flexible solid structures in a transverse shear flow. Comparative investigations with different model setups and increasing complexity are presented. It is shown, that the CFD method with an interface-based coupling approach is not capable of handling small fibre diameters in comparison to large fluid domains due to mesh dependencies at the interface definitions. The ALE method is more suited for this task since fibres are embedded without any mesh restrictions. Element types beam, solid, and discrete are considered for fibre modelling. It is shown that the beam formulation for ALE and 3D solid elements for the CFD method are the preferred options.
Lithium Accumulation in Salvinia natans Free-Floating Aquatic Plant
Authors: Török Anamaria Iulia , Moldovan Ana , Kovacs Eniko , Cadar Oana , Becze Anca , Levei Erika Andrea , Neag Emilia
Published: October 2022

The new context of the intensive use of lithium-based batteries led to increased production of Li and Li-containing wastes. All these activities are potential sources of environmental pollution with Li. However, the negative impact of Li on ecosystems, its specific role in the plants’ development, uptake mechanism, and response to the induced stress are not fully understood. In this sense, the Li uptake and changes induced by Li exposure in the major and trace element contents, photosynthetic pigments, antioxidant activity, and elemental composition of Salvinia natans were also investigated. The results showed that Salvinia natans grown in Li-enriched nutrient solutions accumulated much higher Li contents than those grown in spring waters with a low Li content. However, the Li bioaccumulation factor in Salvinia natans grown in Li-enriched nutrient solutions was lower (13.3–29.5) than in spring waters (13.0–42.2). The plants exposed to high Li contents showed a decrease in their K and photosynthetic pigments content, while their total antioxidant activity did not change substantially.
Molecular Cocrystals with Hydrogen-Bonded Polymeric Structures and Polarized Luminescence
Authors: Zhao Jing-Yi , Xu Fa-Feng , Li Zhong-Qiu , Gong Zhong-Liang , Zhong Yu-Wu , Yao Jiannian
Published: October 2022

Crystalline materials with appealing luminescent properties are attractive materials for various optoelectronic applications. The in situ bicomponent reaction of 1,2-ethylenedisulfonic acid with 1,4-di(pyrid-2-yl)benzene, 1,4-di(pyrid-3-yl)benzene, or 1,4-di(pyrid-4-yl)benzene affords luminescent crystals with hydrogen-bonded polymeric structures. Variations in the positions of the pyridine nitrogen atoms lead to alternating polymeric structures with either a ladder- or zigzag-type of molecular arrangement. By using a nanoprecipitation method, microcrystals of these polymeric structures are prepared, showing polarized luminescence with a moderate degree of polarization.
A Theoretical Investigation into the Homo- and Hetero-leptic Cu(I) Phosphorescent Complexes Bearing 2,9-dimethyl-1,10-phenanthroline and bis [2-(diphenylphosphino)phenyl]ether Ligand
Authors: Shen Lu , Wang Yu-Yang , He Teng-Fei , Zou Lu-Yi , Guo Jing-Fu , Ren Ai-Min
Published: October 2022

Cu(I) complexes have received widespread attention as a promising alternative to traditional noble-metal complexes. Herein, we systematically study the properties of Cu(I) complexes from homo- to hetero-ligands, and found the following: (1) hetero-ligands are beneficial to regulate phosphorescent efficiency; (2) when the hetero-ligands in a tetracoordinated Cu(I) complex are 1:1, the ligands coordinate along the dx2-y2 direction of Cu(I) ion, which can observably suppress structural deformation; (3) unlike the P^P ligand, the N^N ligand can enhance the participation of Cu(I) during the transition process; (4) the addition of an appropriate amount of P^P ligand can effectively raise the energy level of HOMO (highest occupied molecular orbital), enhance the proportion of LLCT (ligand–ligand charge transfer), and thereby increase the available singlet emission transition moments which can be borrowed, thus promoting the radiative decay process. As a result, this work provides a detailed understanding of the effects of different ligands in Cu(I) complexes, and provides a valuable reference and theoretical basis for regulating and designing the phosphorescent properties of Cu(I) complexes in the future.