bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the role of
MAB_1915
in intrinsic resistance to multiple drugs in
Mycobacterium abscessus
Authors: Yusuf Buhari , Wang Shuai , Alam Md Shah , Zhang Jingran , Liu Zhiyong , Lu Ziwen , Ding Jie , Chiwala Gift , Gao Yamin , Fang Cuiting , Khan Shahzad Akbar , Tian Xirong , Islam Md Mahmudul , Hameed H. M. Adnan , Maslov Dmitry A. , Zhong Nanshan , Hu Jinxing , Zhang Tianyu
Published: August 2024

The increasing clinical significance of
Mycobacterium abscessus
is owed to its innate high-level, broad-spectrum resistance to antibiotics and therefore rapidly evolves as an important human pathogen. This warrants the identification of novel targets for aiding the discovery of new drugs or drug combinations to treat
M. abscessus
infections. This study is inspired by the drug-hypersensitive profile of a mutant
M. abscessus
(U14) with transposon insertion in
MAB_1915
. We validated the role of
MAB_1915
in intrinsic drug resistance in
M. abscessus
by constructing a selectable marker-free in-frame deletion in
MAB_1915
and complementing the mutant with the same or extended version of the gene and then followed by drug susceptibility testing. Judging by the putative function of MAB_1915, cell envelope permeability was studied by ethidium bromide accumulation assay and susceptibility testing against dyes and detergents. In this study, we established genetic evidence of the role of
MAB_1915
in intrinsic resistance to rifampicin, rifabutin, linezolid, clarithromycin, vancomycin, and bedaquiline. Disruption of
MAB_1915
has also been observed to cause a significant increase in cell envelope permeability in
M. abscessus
. Restoration of resistance is observed to depend on at least 27 base pairs upstream of the coding DNA sequence of
MAB_1915
. MAB_1915 could therefore be associated with cell envelope permeability, and hence its role in intrinsic resistance to multiple drugs in
M. abscessus
, which presents it as a novel target for future development of effective antimicrobials to overcome intrinsic drug resistance in
M. abscessus
.

IMPORTANCE

This study reports the role of a putative fadD (MAB_1915) in innate resistance to multiple drugs by
M. abscessus
, hence identifying MAB_1915 as a valuable target and providing a baseline for further mechanistic studies and development of effective antimicrobials to check the high level of intrinsic resistance in this pathogen.
Evaluating decision regret after extremely preterm birth
Authors: Belden Laura , Kaempf Joseph , Mackley Amy , Kernan-Schloss Finley , Chen Chiayi , Sturtz Wendy , Tomlinson Mark W , Guillen Ursula
Published: August 2024

Objectives

Little is known about decision regret following extremely premature birth. We assessed decision regret in women who delivered an extremely premature infant, comparing decision regret scores based on resuscitation decision.

Methods

Electronic survey assessment of decision regret using a validated tool included women who delivered at 22–25 completed weeks of gestation at two hospitals 2004–2019. Comparison of ‘active care’, ‘comfort care’ and ‘other’ groups was quantified and comments reviewed.

Results

442 of 787 (56%) eligible women were contacted, 242 of 442 (55%) completed surveys, response rate 242 of 787 (31%). Women not contacted were younger (p=0.0001) and/or delivered in an earlier year (p=0.002). There was a higher percentage of white women who completed the survey (p=0.004). Decision regret was elevated in all groups, varied widely, but was lower in ‘active care’ compared with ‘comfort care’ (Decision Regret Score 14 vs 39, p<0.0001). Lower decision regret occurred in women who recalled a prenatal consult (p=0.014) or identified as the primary decision-maker compared with women who perceived the doctor had a major role (p=0.02) or made the decision (p<0.0001). Lower decision regret occurred in women whose infant was alive at survey completion compared with women whose infant died in the hospital (p<0.0001) or after discharge (p=0.01).

Conclusions

Decision regret was elevated in all groups. Women who recalled prenatal consultation, identified as the primary decision-maker, chose intensive care and/or whose infant survived had lower regret scores.

Clinical trial registration

NCT04074525
.
Medical malpractice claims and state medical board complaints among United States neurointerventionalists
Authors: Fargen Kyle M , Iyer Ankitha M , Mocco J , Fifi Johanna T , Dabus Guilherme , Fraser Justin F , Hirsch Joshua A , Jayaraman Mahesh V
Published: August 2024

Background

Surgeons are at high risk for malpractice claims, which can significantly impact physician quality of life and risk of burnout. There are few published data reporting the incidence, outcomes, and repercussions of malpractice lawsuits on neurointerventionalists.

Methods

A survey of senior members of the United States Society of Neurointerventional Surgery (SNIS) was performed to study malpractice litigation and medical board complaints.

Results

In total, 173 responses were obtained. Of the total sample, 66 respondents (38.2%) reported being subject to a total of 84 malpractice claims during independent practice over the last 10 years, amounting to a malpractice claim annual incidence of 5.9% (84 cases per 1423 years of practice). The majority of claims involved either brain aneurysms (34.5%) or arteriovenous malformations (23.8%), with most alleging either intra-procedural (38.1%) or post-procedural (27.3%) complications. Only three of the 58 claims that had concluded ended in court settlements (5.2%). The majority (78.3%) of claims resulted in no consequences to physician practice. Fourteen respondents (8.1%) reported being subject to a total of 16 state medical board complaints over the previous decade, with most resulting in no significant repercussions.

Conclusion

Malpractice claims are common among neurointerventionalists and often cause significant physician distress, yet most result in claims being dropped or no paid damages, and the majority conclude without practice repercussions for the named physicians.
Magnitude of systolic blood pressure reduction following endovascular treatment and clinical outcomes in acute large artery occlusion stroke
Authors: Huang Xianjun , Ding Xianhui , Wang Hao , Cai Qiankun , Xu Junfeng , Li Zibao , Yang Qian , Zhou Zhiming , Xu Jie
Published: August 2024

Background

The impact of lowering systolic blood pressure (SBP) following endovascular treatment (EVT) in acute large vessel occlusion stroke (LVOS) patients remains unclear. We aimed to explore the effect of the magnitude of SBP reduction (SBPr) after EVT on outcomes in LVOS patients.

Methods

We consecutively registered patients at three comprehensive stroke centres who had experienced EVT as a result of acute anterior circulation LVOS. SBPr was calculated as follows: (baseline SBP−mean SBP/baseline SBP)×100%. The 90-day modified Rankin Scale score ranging from 0 to 2 was defined as a favourable functional outcome. Based on CT scans obtained within 24 hours after procedure, symptomatic intracranial haemorrhage (sICH) was assessed according to the criteria of the European Cooperative Acute Stroke Study III.

Results

We enrolled 1080 patients, of which 908 (84.1%) had successful recanalisation. In the overall cohort, SBPr was correlated with lower odds of sICH (SBPr±10% as a reference, 20%–30%: OR 0.460; 95% CI: 0.245 to 0.864; p=0.016; >30%: OR 0.304; 95% CI 0.123 to 0.749; p=0.010). In patients who achieved successful reperfusion, SBPr>30% was correlated with higher odds of a poor outcome (SBPr±10% as a reference, OR 2.150; 95% CI 1.268 to 3.645; p=0.004) and SBPr has a similar tendency towards reducing the incidence of sICH. In the subgroup analyses, baseline Alberta Stroke Programme Early CT (ASPECT) score (pinteract=0.024) modified the effect of SBPr on the 90-day outcome.

Conclusion

Among patients with EVT, a significant drop in SBP may be related to a poor functional outcome and a reduced incidence of sICH. Baseline ASPECT score may be an important interacting factor in the association of SBPr with the 90-day outcome. This study provides new insights for individualised BP management in patients with EVT.
The influence of experimental conditions on absolute beam density measurements for NH$$_3$$ and H
Authors: Pandey Rahul , Wu Lok Yiu , Morris Lucy , Regan Paul , Heazlewood Brianna R.
Published: August 2024

In order to establish important reaction properties, such as rate coefficients, it is often necessary to know the number of reactants that are present in an interaction region. The absolute number densities of pulsed supersonic molecular (NH$$_3$$

3

) and atomic (H) beams are reported using a laser-based detection method, under a range of experimental conditions including photolysis, Zeeman deceleration, and magnetic focusing. Time-averaged densities of (3.6 ± 2.7) $$\times $$
×
 10$$^4$$

4

 cm$$^{-3}$$

-
3

are reported for successfully Zeeman-decelerated and magnetically focused H atoms, generated by the photodissociation of precursor NH$$_3$$

3

molecules. Without the magnetic guide components in the beamline, the density of the target radicals of interest is somewhat lower, at (2.5 ± 1.8) $$\times $$
×
10$$^4$$

4

 cm$$^{-3}$$

-
3

. The average density of the undecelerated H atom beam is approximately an order of magnitude higher (2.9 ± 1.9) $$\times $$
×
10$$^5$$

5

 cm$$^{-3}$$

-
3

, with the average density of the molecular ammonia beam over two orders of magnitude higher again (5.1 ± 2.9) $$\times $$
×
10$$^7$$

7

 cm$$^{-3}$$

-
3

. The average number densities measured for the two different species of interest in this work span more than three orders of magnitude. These findings highlight the need for accurate and precise experimental measurements of number densities—for each species of interest, under the appropriate experimental conditions—before doing absolute rate coefficient calculations.

Graphical abstract
New insight to the shallow-water studies on a (2+1)-dimensional generalized Broer-Kaup system
Authors: Gao Xin-Yi , Guo Yong-Jiang , Shan Wen-Rui
Published: August 2024

Of current interest, there have recently appeared a series of the shallow-water papers in Mod. Phys. Lett. B. Illuminated by those papers and to make the story more complete, for the nonlinear long waves in the shallow water, this paper is scheduled to investigate a (2+1)-dimensional generalized Broer-Kaup system. As for the wave height and wave horizontal velocity, we employ symbolic computation, with the view of constructing out two groups of the similarity reductions.
Road Design and Traffic Detection Methods for Autonomous Driving Scenarios
Authors: Bai Kang , Fang Xiangming
Published: August 2024

With the rapid promotion of autonomous driving technology, it is extremely important to scientifically anticipate the related technologies and analyze their possible impact on urban road systems. The accuracy of detection and localization of traffic elements of autonomous driving is closely related to the ability of autonomous driving devices to make control decisions and the safety of autonomous driving. The study designs a new high-speed road driving scheme based on autonomous driving by analyzing the challenges related to urban traffic that may be brought about by unmanned driving. On the basis of the faster R-CNN algorithm, the context information around the target is introduced to locate and detect small-scale traffic signs. A new pedestrian detection model is designed, which is based on the feature pyramid network and introduces the SE module to highlight the features of the visible part of the pedestrian and reduce the missed detection rate caused by inter-class occlusion. The improved traffic sign detection framework improves the detection accuracy by 18.91% compared to the original faster R-CNN, while the enhanced pedestrian inspection method improves the detection accuracy by 14.00%. For both traffic sign detection and pedestrian detection accuracy and speed are improved compared to the original method.
Bistability and bifurcations for a food chain model with nonlinear harvesting of top predator
Authors: Wang Shaoli , Chai Nannan , Wang Xiao , Xu Fei
Published: August 2024

In this paper, we study a prey–predator–top predator food chain model with nonlinear harvesting of top predator. We have derived two important thresholds: the top predator extinction threshold and the coexistence threshold. We found that the top predator will die out if the nonlinear harvesting from predator to top predator is larger than the top predator extinction threshold. On the other hand, the prey, predator and top predator coexist if the nonlinear harvesting from predator to top predator is less than the coexistence threshold. While the parameter value of nonlinear harvesting from predator to top predator is between two critical thresholds, the system displays bistability phenomena, implying that the top predator species either die out or exist with the prey and predator species, which largely depend on the initial condition. Thus, a bistable interval exists between two critical thresholds, which is a significant phenomenon for the model. Meanwhile, we performed bifurcation analysis for the model, showing that the system would arise backward/forward bifurcation and saddle-node bifurcation and Hopf bifurcation. Finally, we performed numerical simulations to verify the theoretical analysis.
Ecological and epidemiological ramification of fear: Exploring deterministic and stochastic dynamics in a predator–prey system with predator switching and harvesting
Authors: Mandal Sayan , Tripathi Amita , Banerjee Ritwick , Souna Fethi , Tiwari Pankaj Kumar
Published: August 2024

In an ecosystem, harvesting infected prey can assist in managing and containing the spread of the illness within the prey species. On the other hand, the harvesting of predators can be beneficial as it regulates their numbers, preventing them from over-consuming prey and subsequently preserving existence of the prey population. This study introduces a predator–prey model that encompasses prey infection, predator–prey interactions influenced by fear, switching and harvesting. We derive an analytic expression for the basic reproduction number, a critical determinant of disease spread. We investigate the global stability of disease-free and endemic equilibria contingent on the basic reproduction number’s value, highlighting the potential for disease eradication by maintaining it below unity. In-depth analysis of the deterministic model is undertaken, with a focus on Hopf bifurcations that delineate thresholds for disease-free and endemic states. Furthermore, the deterministic model is extended to incorporate environmental stochasticity. We obtain the conditions under which population extinction occurs. Our findings elucidate how the intensity of environmental noise influences population dynamics, providing valuable insights into extinction risks under varying noise levels.
Could California's groundwater resource management lessons be beneficial to England?
Authors: Parker Tom , Brown Anthony
Published: August 2024

In California, Groundwater Sustainability Agencies (GSAs) are basin/catchment-specific water organizations mandated by the Sustainable Groundwater Management Act of 2014 to manage groundwater sustainably by 2040/2042. A GSA can charge replenishment fees for pumped groundwater and these fees can be used to: (a) monitor basin hydrologic conditions; (b) improve the water budget accuracy; (c) increase water availability through management actions and projects; (d) mitigate undesirable results; and/or (e) pay for activities including issuing allocations and limiting production to allocations.

In England, housing is frequently proposed in river basin catchments that face water resource challenges. High profile examples are the Arun Valley and Cambridge. The current National Planning Policy Framework manages water resource planning strategically through water company Water Resource Management Plans or Environment Agency River Basin Management Plans. These processes can be slow to respond to development requirements.

England might look to California's practices that require water users and developers to pay for ‘water credits’ or fees. This could involve a ‘Watermaster’ charged with local or catchment scale resource management and project implementation. This Watermaster could engage all stakeholders including the local water company, farmers, the Environment Agency and the local authority, none of whom is well positioned to act in isolation.
Automatic Test Pattern Generation for Robust Quantum Circuit Testing
Authors: Chen Kean , Ying Mingsheng
Published: August 2024

Quantum circuit testing is essential for detecting potential faults in realistic quantum devices, while the testing process itself also suffers from the inexactness and unreliability of quantum operations. This article alleviates the issue by proposing a novel framework of automatic test pattern generation (ATPG) for robust testing of logical quantum circuits. We introduce the stabilizer projector decomposition (SPD) for representing the quantum test pattern and construct the test application (i.e., state preparation and measurement) using Clifford-only circuits, which are rather robust and efficient as evidenced in the fault-tolerant quantum computation. However, it is generally hard to generate SPDs due to the exponentially growing number of the stabilizer projectors. To circumvent this difficulty, we develop an SPD generation algorithm, as well as several acceleration techniques that can exploit both locality and sparsity in generating SPDs. The effectiveness of our algorithms are validated by (1) theoretical guarantees under reasonable conditions and (2) experimental results on commonly used benchmark circuits, such as Quantum Fourier Transform (QFT), Quantum Volume (QV), and Bernstein-Vazirani (BV) in IBM Qiskit.
AmLuCEP: Amalgamating LUT-based Compression and Adaptive Encoding Assisted Block Placement To Improve Lifetime of PCM-based Main Memories
Authors: Nath Arijit , Kapoor Hemangee K.
Published: August 2024

With the rising demands for high capacity memory and poor scalability of the existing DRAM-based main memories, the emerging Non-volatile memories captures higher attention due to their high density and low leakage power consumption. However, the possible consideration of such memories as alternatives of DRAM is largely hindered by their intrinsic drawbacks like high write latency, high write energy and low write endurance. In this article, we propose an integrated solution by combining the effect of compression and encoding assisted block placement to improve lifetime of NVMs. We have developed a compression technique called
LUT_Comp
by exploiting the word-level redundancy present in the words of the incoming cache blocks to NVM.
LUT_Comp
remains effective in reducing bit-flips in NVMs by offering a balance in compression ratio and coverage (Cov). Additionally, we also propose an encoding based block placement policy that places the compressed blocks in the appropriate half within the memory. The integrated approach of compression and block placement termed AmLuCEP offers a uniform bit-flips distribution while further reducing bit-flips in NVM. Experimental results show that AmLuCEP reduces bit-flips by 54%, 42%, 37%, 21%; energy consumption by 41%, 28%, 24%, 13%; and improves lifetime by 57%, 40%, 38%, 21% over baseline and the existing techniques READ [
38
], COEF [
39
] and SELEC [
13
], respectively.
DELTA: Memory-Efficient Training via Dynamic Fine-Grained Recomputation and Swapping
Authors: Tang Yu , Li Qiao , Yin Lujia , Li Dongsheng , Zhang Yiming , Wang Chenyu , Zhang Xingcheng , Qiao Linbo , Zhang Zhaoning , Lu Kai
Published: August 2024

To accommodate the increasingly large-scale models within limited-capacity GPU memory, various coarse-grained techniques, such as recomputation and swapping, have been proposed to optimize memory usage. However, these methods have encountered limitations, either in terms of inefficient memory reduction or diminished training performance. In response to this, our article introduces dynamic tensor offloading and recomputation (DELTA), an innovative approach for memory-efficient large-scale model training that combines fine-grained memory optimization and prefetching technology to reduce memory usage while maintaining high training throughput concurrently. Initially, we formulate the problem of memory-throughput joint optimization as an easy-solving 0/1 Knapsack problem. Leveraging this formalization, we use an improving polynomial complexity heuristic algorithm to address the problem effectively. Furthermore, we introduce, to the best of our knowledge, a novel bidirectional prefetching technology into dynamic memory management that significantly accelerates the model training when compared to relying solely on recomputation or swapping. Finally, DELTA offers users an automated training execution library, eliminating the need for manual configuration or specialized expertise. Experimental results demonstrate the effectiveness of DELTA in reducing GPU memory consumption. Compared to state-of-the-art methods, DELTA achieves substantial memory savings ranging from 40% to 72%, while maintaining comparable convergence performance for various models, including ResNet-50, ResNet-101, and BERT-Large. Notably, DELTA enables the training of GPT2-Large and GPT2-XL with batch sizes increased by 5.5× and 6×, respectively, showcasing its versatility and practicality in enabling large-scale model training on GPU hardware.
Pain Experience and Image Quality with Curved versus Standard Compression for Breast Cancer Screening Mammography: A Randomized Controlled Trial
Authors: van der Waal Daniëlle , van Landsveld-Verhoeven Cary , Tetteroo Eric , van Engen Ruben E. , Sechopoulos Ioannis , Pijnappel Ruud M. , Broeders Mireille J. M.
Published: August 2024

A curved compression system for breast cancer screening mammography resulted in marginal pain reduction, with decreased contrast and visibility of structures, compared with images acquired with the standard system.
Investigating the Reliability of Ground Motion Intensity Measures
Authors: Jafari Ali , Rajabi Elham , Ghodrati Amiri Gholamreza
Published: August 2024

The uncertainty and unreliability in the probabilistic seismic demand models (PSDMs) can be addressed in the framework of performance‐based earthquake engineering (PBEE). Some characteristics have been introduced and extensively investigated in the earthquake engineering literature for appropriateness (i.e., optimality) of various intensity measures, such as efficiency, effectiveness, sufficiency, practicality, and hazard computability. The reliability of the intensity measures can also be considered as another important criterion for intensity measure (IM) selection, which has not been investigated extensively. In this paper, a framework has been developed and implemented to investigate the reliability of various intensity measures alongside the number of adopted earthquake records. In this regard, the inverse of the mean coefficient of variation (IMCV), which is detected to be in a direct and linear relationship with the number of earthquake records, is adopted as the main criterion to compare the reliability of ground motion intensity measures. A simple relation has been proposed and calibrated for the studied IMs that provide the required number of earthquake records to satisfy an intended level of reliability. As a case study, a significant number of recorded ground motions at Zagros and non‐Zagros zones (two major seismic regions in Iran) with rock and soil conditions are selected, and the most reliable ground motion intensity measure is introduced at various seismic regions and soil types by exploiting the developed framework and the proposed relationship.
MEA Cost Reduction through Manufacturing Approaches and Material‐Level Innovation
Authors: Banham Dustin , Peng Ye , Bai Kyoung , Choi Ja-Yeon , Wang Huancheng
Published: August 2024

Globally, the demand for proton exchange membrane fuel cells (PEMFCs) has been growing exponentially. For this growth to continue, it is imperative that the cost of PEMFC technology continues to decrease. While most cost reduction strategies focus on a reduction in the loading of platinum group metals (PGMs), for a large portion of the fuel cell community, these approaches are not yet viable as they require advanced system strategies and unification of the system, stack, membrane electrode assembly (MEA), and component teams which is not widely achieved in the broader fuel cell market. Unlike prior discussions on this topic which depend upon the incorporation of novel materials or significantly larger manufacturing volumes, in this overview, more immediately achievable cost reduction methods are examined to determine a reasonable cost target that can be achieved without having to target ultralow PGM loadings. It will be shown that through rational selection of available Pt/C catalysts for specific applications, sourcing of core materials within China, and improvements in the production process to reduce waste, the MEA price can reach levels of <USD 0.06 W−1 even with conventional PGM loadings (e.g., 0.07 mg cm−2 anode and 0.3 mg cm−2 cathode).
Agreement of Peru‐Based Allergy Tests for Respiratory Allergens in Allergic Rhinitis Patients
Authors: Galván César , Totesaut Margarita , Muñoz Edgar , Durán Rafael , La Rosa Christian , Calderón Oscar
Published: August 2024

Background. The Peruvian Immunoblot panel, together with traditional skin prick tests (SPT), are widely used in vitro allergy tests in Peru. In addition to this, Peruvian allergists are increasingly adopting multiplex tests such as the ALEX‐2 (Macro Array Diagnostics). Previous studies have revealed limited agreement between Immunoblot and SPT results. Therefore, our study aimed to evaluate the concordance between these three tests in patients with allergic rhinitis (AR) in a private center in Arequipa, Peru. Materials and Methods. We enrolled 35 patients, including children over 3 years and adults, with AR. Clinical and demographic data were collected, and patients underwent allergic sensitization testing using the Immunoblot Peruvian panel (32 allergens), ALEX‐2 (295 allergens), and SPT (12 allergens). Concordance was calculated using Cohen’s kappa coefficient and analyzed with IBM SPSS V26. Results. Among the patients, 34.3% exhibited moderate‐to‐severe persistent AR, and 14.3% had asthma. Additionally, 85.7% reported a family history of AR. Sensitization rates varied notably between the SPT and ALEX‐2, particularly for olive pollen (34.3% vs. 17.4%), Blomia tropicalis (11.4% vs. 17.1%), and grasses (11.4% vs. 28.5%). Remarkably, these allergens were not included in the Peruvian Immunoblot panel. Concordance analysis included seven allergens and showed significant concordance between ALEX‐2 and SPT for five allergens, between Immunoblot and SPT for two allergens, and between ALEX‐2 and Immunoblot for two allergens. Conclusion. This preliminary study shows us a better concordance between ALEX‐2 and SPT rather than between Immunoblot and SPT.
Integrative Geospatial Analysis: Unveiling Insights through GIS Modeling and Statistical Evaluation of SPT‐N and Soil Types Data of New Kabul City, Afghanistan
Authors: Amini Mohammad , Deng Longsheng , Hassan Waqas , Nawaz Muhammad Naqeeb , Zidane Fatima Zahra , Fang Ranke
Published: August 2024

The precise evaluation of subsurface soil information is paramount for effective infrastructure design and planning. Geotechnical soil maps (GSMs) play a pivotal role in estimating subsurface properties. As Kabul City, Afghanistan’s largest metropolitan area, undergoes rapid expansion and the demand for safer infrastructure rises, the necessity for precise geotechnical information becomes increasingly urgent. Nevertheless, there is a lack of comprehensive studies on urban geotechnical zoning maps in Afghanistan. Therefore, to this end, this study utilizes inverse distance weighting (IDW) interpolation approaches for the construction and characterization of GSMs using a traditional geographic information system (GIS). Data about soil types and standard penetration (N‐value) up to 30 m depth were extracted from 130 locations in New Kabul City, Afghanistan. GSMs incorporating N‐value and soil types were constructed utilizing the IDW technique within the ArcGIS platform. The outcomes reveal that the subjected region was dominated by cohesive soil with N‐values varying from 7 to 45 in three different sections. The findings exhibit strong empirical correlations between N‐values and depth, with an R2 value of 0.95 and an RMSD value of 0.71. Moreover, the correlation coefficient to predict soil type classification is 97%, and it stands at 95% for N‐value prediction. These results facilitate the rapid evaluation of subsoil strength and stiffness, offering valuable insights for project planners and feasibility researchers.
Supplementary Data from Temozolomide Sensitizes ARID1A-Mutated Cancers to PARP Inhibitors
Authors: Yu Zheng-Cheng , Li Tianhe , Tully Ellen , Huang Peng , Chen Chih-Ning , Oberdoerffer Philipp , Gaillard Stephanie , Shih Ie-Ming , Wang Tian-Li
Published: August 2024

Supplementary Figures
Supplementary Data from Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma
Authors: Rohila Deepak , Park In Hwan , Pham Timothy V. , Weitz Jonathan , Hurtado de Mendoza Tatiana , Madheswaran Suresh , Ishfaq Mehreen , Beaman Cooper , Tapia Elisabette , Sun Siming , Patel Jay , Tamayo Pablo , Lowy Andrew M. , Joshi Shweta
Published: August 2024

Supplementary table
Supplementary Figure S7 from Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
Authors: Johanns Tanner M. , Garfinkle Elizabeth A.R. , Miller Katherine E. , Livingstone Alexandra J. , Roberts Kaleigh F. , Rao Venkata Lakshmi P. , Dowling Joshua L. , Chicoine Michael R. , Dacey Ralph G. , Zipfel Gregory J. , Kim Albert H. , Mardis Elaine R. , Dunn Gavin P.
Published: August 2024

CDR3beta sequences ranked by abundance
Targeting PDHK1 by DCA to Restore NK Cell Function in Hepatocellular Carcinoma
Authors: Yang Xinyi , Liu Yuanyuan , Wang Peng , Li Min , Xiang Tong , Xie Songzuo , Li Minxing , Wang Yan , Weng Desheng , Zhao Jingjing
Published: August 2024

Pyruvate dehydrogenase complex is a crucial enzyme involved in the oxidation of glucose. It is regulated by pyruvate dehydrogenase kinase (PDHK) and pyruvate dehydrogenase phosphatase. Studies have demonstrated that PDHK1, a key enzyme in glucose metabolism, behaves like oncogenes. It is highly expressed in tumors and is associated with poor patient prognosis. However, there is limited research on how PDHK1 affects immune cell function. We have established a model of NK cell exhaustion to investigate the impact of dichloroacetate (DCA) on NK cell function. The production of granzyme B, IFNγ, TNFα, and CD107a by NK cells was explored by flow cytometry. The real-time live-cell imaging system was used to monitor the ability of NK cells against tumor cells. The Seahorse analyzer was utilized to measure the oxygen consumption rate and extracellular acidification rate of NK cells. A mouse model was used to investigate the potential of combining DCA with adjuvant NK cell infusion. Our study demonstrated that the hepatocellular carcinoma microenvironment mediated NK cellular exhaustion and high expression of PDHK1 and reduced cytokine secretion. We discovered that the PDHK1 inhibitor DCA enhances the activity and function of exhausted NK cells infiltrating the tumor microenvironment. Furthermore, in a s.c. hepatocellular carcinoma mouse model, DCA combined with NK cell treatment resulted in retarding cancer progression. This study indicates the potential of DCA in rescuing NK cell exhaustion and eliciting antitumor immunity.
Table S6 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S6 shows AEs with Attribution Possible, Probable or Definite to Docetaxel listed by types and grades
Supplemental Table S5 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

Full multivariable model evaluating the association between nonsignificant trial-level factors and the percentage of SEPs published.
Table S3 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S3 shows Adverse Events Included in the Co-Primary Endpoint: All Occurrences
Supplemental Table S4 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

Full multivariable model evaluating the association between significant trial-level factors and the percentage of SEPs published.
Supplemental Table S3 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: August 2024

Distribution of the types of correlatives and their respective publication rates.
Table S16 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S16 shows Comparison of F2-Isoprostanes Control and Intervention Changes 60 minutes after Cycle 4
Table S14 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S14 shows Comparison of F2-Isoprostanes Control and Intervention Changes (post - pre) Immediately after Cycle 4
Table S13 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S13 shows Comparison of F2-Isoprostanes at Baseline between Treatment and Control Arms
Table S12 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S12 shows Comparison of FACT-P Change Scores Between Study Arms: Mean Difference Docetaxel + HDVIC Minus Docetaxel + Placebo
Table S10 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: August 2024

Table S10 shows ANCOVA Least-squares Means for Cycle 4, 6, and 8 FACT-P Total by Study Arm
A Database Tool Integrating Genomic and Pharmacologic Data from Adrenocortical Carcinoma Cell Lines, PDX, and Patient Samples
Authors: Arakawa Yasuhiro , Elloumi Fathi , Varma Sudhir , Khandagale Prashant , Jo Ukhyun , Kumar Suresh , Roper Nitin , Reinhold William C. , Robey Robert W. , Takebe Naoko , Gottesman Michael M. , Thomas Craig J. , Boeva Valentina , Berruti Alfredo , Abate Andrea , Tamburello Mariangela , Sigala Sandra , Hantel Constanze , Weigand Isabel , Wierman Margaret E. , Kiseljak-Vassiliades Katja , Del Rivero Jaydira , Pommier Yves
Published: August 2024

Adrenocortical carcinoma (ACC) is a rare and highly heterogeneous disease with a notably poor prognosis due to significant challenges in diagnosis and treatment. Emphasizing on the importance of precision medicine, there is an increasing need for comprehensive genomic resources alongside well-developed experimental models to devise personalized therapeutic strategies. We present ACC_CellMinerCDB, a substantive genomic and drug sensitivity database (available at https://discover.nci.nih.gov/acc_cellminercdb) comprising ACC cell lines, patient-derived xenografts, surgical samples, and responses to more than 2,400 drugs examined by the NCI and National Center for Advancing Translational Sciences. This database exposes shared genomic pathways among ACC cell lines and surgical samples, thus authenticating the cell lines as research models. It also allows exploration of pertinent treatment markers such as MDR-1, SOAT1, MGMT, MMR, and SLFN11 and introduces the potential to repurpose agents like temozolomide for ACC therapy. ACC_CellMinerCDB provides the foundation for exploring larger preclinical ACC models.

Significance:

ACC_CellMinerCDB, a comprehensive database of cell lines, patient-derived xenografts, surgical samples, and drug responses, reveals shared genomic pathways and treatment-relevant markers in ACC. This resource offers insights into potential therapeutic targets and the opportunity to repurpose existing drugs for ACC therapy.
Raças e racismos, junções e disjunções
Authors: Guimarães Antonio Sérgio Alfredo
Published: August 2024

Nesse artigo, exploro as razões para que se tenha desenvolvido no presente século, no interior da tradição das ciências sociais, a necessidade de se conceituar o racismo, assim como as razões por que tal conceituação é ainda, nos dias que correm, fortemente controversa. Isso me leva a discutir a relação entre racismo e raça, e o desenvolvimento do uso analítico do termo raça nas ciências sociais. Ao fazer essa discussão, defenderei duas teses simples, mas radicais: a de que não há como conceituar racismo sem referência a raças, assim como não há racismo sem agência humana.
Racismo no Brasil: de hipótese à premissa, sem passar por objeto
Authors: Campos Luiz Augusto
Published: August 2024

The area study of race relations is one of the oldest and most consolidated in Brazilian Social Sciences. Yet  paradoxically, there is still little research focused on understanding and explaining Brazil’s racism, its mechanisms and characteristics. In addition to illustrating these claims, this text aims to explain why the mechanisms of racial discrimination still manage to escape the radar of sociology and, above all, to outline  the general lines of a research  agenda that takes discrimination as an object of investigation. It seems that racial discrimination stopped being a research hypothesis, reformulated and tested in different ways between the 1970s and 1990s, to become a premise in the area from the 2000s onwards. However, this  came to be without racism being properly constructed as an object of sociological research itself.
Yascha Mounk. The identity trap: a story of ideas and power in our time
Authors: Miguel Luis Felipe
Published: August 2024

Book review: The identity trap: a story of ideas and power in our time, Nova York, Penguin, 2023, by Yascha Mounk.
Aparecida Sueli Carneiro. Dispositivo de racialidade: a construção do outro como não ser como fundamento do ser
Authors: Delphino Gabriel
Published: August 2024

Resenha do livro de Aparecida Sueli Carneiro, Dispositivo de racialidade: a construção do outro como não-ser como fundamento do ser, Rio de Janeiro, Zahar, 2023.
As Transformações do Racismo Estrutural: entrevista com Eduardo Bonilla-Silva
Authors: Campos Luis Augusto , Lima Marcia , Delphino Gabriel
Published: August 2024

Eduardo Bonilla-Silva is internationally recognized as one of the leading proponents of the concept of "structural racism." Born in 1968 in Puerto Rico, he served as president of the American Sociological Association (ASA) in 2018. Currently a professor at Duke University, Bonilla-Silva has argued that the racialization of our social structures is more effective in reproducing inequalities than explicitly racist ideologies or political doctrines. In 2003, he published "Racism without Racists" (translated to Portuguese by Perspectiva in 2020), a book in which he suggests that the contemporary world experiences a "color-blind racism," wherein racial discrimination continues to operate despite widespread condemnation of racist values by various political movements. Despite the increasingly common use of the notion of structural racism, Bonilla-Silva's works remain relatively unknown in Brazil. For this reason, we conducted this interview with him in September 2023, addressing topics such as the structuring of racism in today's world, the impact of events like the brutal murder of George Floyd in the U.S., and the current challenges of anti-racism in Brazil and globally.
Contribuições marxistas às Relações Internacionais
Authors: Botão Gustavo Rocha
Published: August 2024

Theory of International Relations: Marxist contributions, by Ana Prestes and Diego Pautasso, is a publication of great relevance to the field of International Relations studies by presenting the reader with several Marxist interpretations on themes such as imperialism, hegemony, center-periphery relationship and social classes. In this work, divided into twelve chapters, several Marxist researchers participated, who discussed the themes mentioned above from their approaches, always seeking to bring the state of the art in terms of theory and research. In this sense, the work is able to provide the reader with the most advanced Marxist contributions to International Relations.
Democracia no Brasil e Violência Política de Gênero: dois lados da mesma moeda?
Authors: Simioni Fabiane
Published: August 2024

Este artículo examina la interconexión entre la democracia brasileña y el déficit de representación de las mujeres y otros grupos sociales históricamente marginados en la escena política nacional. Basado en una revisión exhaustiva de la literatura nacional e internacional, el estudio destaca la importancia de los marcos legales globales, regionales y nacionales, como la Ley del Feminicidio y la Ley de Combate a la Violencia Política contra la Mujer, para el marco normativo de la equidad de género en el ámbito público y privado. Sin embargo, incluso con estos esfuerzos, aún existen resistencias y formas de violencia política de género que impiden la plena participación, especialmente de mujeres cis o transgénero, en la esfera política institucional. Se considera fundamental superar esta violencia no solo para fortalecer la democracia, sino también para construir una sociedad justa e igualitaria.
“The country’s economic recovery will be driven: mothers as moral citizens in Brazilian far-right discourses by women”:
Authors: Garcia Carolina Gallo
Published: August 2024

Partindo do argumento transnacional de que as mulheres representam uma nova fronteira para o desenvolvimento econômico das nações, este artigo analisa um conjunto de discursos de gênero entrelaçados a estreitos ideais de cidadania materna. A partir de uma análise de discurso, analiso a noção de neoliberalismo como tecnologia móvel para ilustrar como o uso de narrativas moralizantes da extrema direita brasileira durante o governo Jair Bolsonaro (2019-2022) enquadra as mulheres como figuras maternas e empreendedoras. Responsáveis por imbuir as futuras gerações com condutas autônomas, destaca-se que as mulheres pobres se tornam moralmente responsáveis por promover o progresso nacional, um enquadramento que tem sido aplicável tanto a orientações neoliberais progressistas quanto neoconservadoras.
Possibilidades e limitações do ensino à distância na educação física adaptada: uma disciplina de síntese
Authors: Silveira Sergio Roberto , Bulgarelli Beatriz Thiemi Miyazato , Rezende Lucas da Silva , Carrascoza Lucas Sertório , Pontes Leandro Baroni Câmara , Pacheco Gabriel Francisco Zago , Souza Roberto Carlos da Silva
Published: August 2024

Resumo do Congresso de Graduação da USP 2021.
Ludificação em meios digitais para o ensino remoto na pandemia: a experiência da disciplina "instrumentos de política e planejamento: um olhar integrado sobre o programa e administração de projetos no campo da economia solidária"
Authors: Fantin Marcel
Published: August 2024

Resumo do Congresso de Graduação da USP 2021.
Algumas contribuições das AACS na formação do estudante de engenharia
Authors: Montanari Luciana , Amaral Daniel Capaldo , Oliveira Vilma Alves de
Published: August 2024

Resumo do Congresso de Graduação da USP 2021.