bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of an ABCB1 (P‐glycoprotein)‐positive carfilzomib‐resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1
Authors: Hawley Teresa S. , Riz Irene , Yang Wenjing , Wakabayashi Yoshiyuki , DePalma Louis , Chang Young‐Tae , Peng Weiqun , Zhu Jun , Hawley Robert G.
Published: January 2013

Multiple myeloma (MM) is characterized by the malignant expansion of differentiated plasma cells. Although many chemotherapeutic agents display cytotoxic activity toward MM cells, patients inevitably succumb to their disease because the tumor cells become resistant to the anticancer drugs. The cancer stem cell hypothesis postulates that a small subpopulation of chemotherapy‐resistant cancer cells is responsible for propagation of the tumor. Herein we report that efflux of the pluripotent stem cell dye CDy1 identifies a subpopulation in MM cell lines characterized by increased expression of P‐glycoprotein, a member of the ABC (ATP‐binding cassette) superfamily of transporters encoded by ABCB1. We also demonstrate that ABCB1‐overexpressing MM cells are resistant to the second‐generation proteasome inhibitor carfilzomib that recently received accelerated approval for the treatment of therapy‐refractive MM by the U.S. Food and Drug Administration. Moreover, increased resistance to carfilzomib in sensitive MM cells following drug selection was associated with upregulation of ABCB1 cell‐surface expression which correlated with increased transporter activity as measured by CDy1 efflux. We further show that chemosensitization of MM cells to carfilzomib could be achieved in vitro by cotreatment with vismodegib, a hedgehog pathway antagonist which is currently in MM clinical trials. CDy1 efflux may therefore be a useful assay to determine whether high expression of ABCB1 is predictive of poor clinical responses in MM patients treated with carfilzomib. Our data also suggest that inclusion of vismodegib might be a potential strategy to reverse ABCB1‐mediated drug resistance should it occur. Am. J. Hematol. 88:265–272, 2013. © 2013 Wiley Periodicals, Inc.
A novel mosaic NSD1 intragenic deletion in a patient with an atypical phenotype
Authors: Castronovo Chiara , Rusconi Daniela , Crippa Milena , Giardino Daniela , Gervasini Cristina , Milani Donatella , Cereda Anna , Larizza Lidia , Selicorni Angelo , Finelli Palma
Published: January 2013

Sotos syndrome, which is characterized by overgrowth, macrocephaly, distinctive facial features, and developmental delay, arises from mutations and deletions of the NSD1 gene at 5q35.3. Sixteen NSD1 intragenic deletions (including one in a mosaic condition) and one partial duplication have been reported in patients with Sotos syndrome. Here, we describe a boy aged 4 years and 10 months that showed facial dysmorphism (including frontal bossing, widely spaced eyes, deeply set eyes, a wide nasal bridge, anteverted nares, and a wide mouth), normal growth, and a psychomotor delay. High‐resolution array comparative genomic hybridization (CGH) analysis identified a mosaic heterozygous intragenic NSD1 deletion of 38 kb, which included part of intron 2 and the entire exon 3, and led to NSD1 haploinsufficiency. The deletion somatic mosaicism was subsequently confirmed by fluorescence in situ hybridization (FISH) analysis using fosmid clones. This patient presents the most atypical phenotype thus far associated with NSD1 haploinsufficiency. It is possible that this atypical phenotype may have resulted from the somatic mosaicism of the NSD1 defect. Our study confirms the usefulness of array CGH for increasing the detection rate of NSD1 abnormalities and for diagnosing syndromic patients that do not present an easily recognized phenotype. © 2013 Wiley Periodicals, Inc.
Deletion at the SLC1A1 glutamate transporter gene co‐segregates with schizophrenia and bipolar schizoaffective disorder in a 5‐generation family
Authors: Myles‐Worsley Marina , Tiobech Josepha , Browning Sharon R. , Korn Jeremy , Goodman Sarah , Gentile Karen , Melhem Nadine , Byerley William , Faraone Stephen V. , Middleton Frank A.
Published: January 2013

Growing evidence for genetic overlap between schizophrenia (SCZ) and bipolar disorder (BPD) suggests that causal variants of large effect on disease risk may cross traditional diagnostic boundaries. Extended multigenerational families with both SCZ and BPD cases can be a valuable resource for discovery of shared biological pathways because they can reveal the natural evolution of the underlying genetic disruptions and their phenotypic expression. We investigated a deletion at the SLC1A1 glutamate transporter gene originally identified as a copy number variant exclusively carried by members of a 5‐generation Palauan family. Using an expanded sample of 21 family members, quantitative PCR confirmed the deletion in all seven individuals with psychosis, three “obligate‐carrier” parents and one unaffected sibling, while four marry‐in parents were non‐carriers. Linkage analysis under an autosomal dominant model generated a LOD‐score of 3.64, confirming co‐segregation of the deletion with psychosis. For more precise localization, we determined the approximate deletion end points using alignment of next‐generation sequencing data for one affected deletion‐carrier and then designed PCR amplicons to span the entire deletion locus. These probes established that the deletion spans 84,298 bp, thus eliminating the entire promoter, the transcription start site, and the first 59 amino acids of the protein, including the first transmembrane Na2+/dicarboxylate symporter domain, one of the domains that perform the glutamate transport action. Discovery of this functionally relevant SLC1A1 mutation and its co‐segregation with psychosis in an extended multigenerational pedigree provides further support for the important role played by glutamatergic transmission in the pathophysiology of psychotic disorders. © 2013 Wiley Periodicals, Inc.
Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14–18, 2012
Authors: Anderson‐Schmidt Heike , Beltcheva Olga , Brandon Mariko D. , Byrne Enda M. , Diehl Eric J. , Duncan Laramie , Gonzalez Suzanne D. , Hannon Eilis , Kantojärvi Katri , Karagiannidis Iordanis , Kos Mark Z. , Kotyuk Eszter , Laufer Benjamin I. , Mantha Katarzyna , McGregor Nathaniel W. , Meier Sandra , Nieratschker Vanessa , Spiers Helen , Squassina Alessio , Thakur Geeta A. , Tiwari Yash , Viswanath Biju , Way Michael J. , Wong Cybele C.P. , O'Shea Anne , DeLisi Lynn E.
Published: January 2013

The XXth World Congress of Psychiatric Genetics (WCPG), sponsored by The International Society of Psychiatric Genetics (ISPG) took place in Hamburg, Germany on October 14–18, 2012. Approximately 600 participants gathered to discuss the latest findings in this rapidly advancing field. The following report was written by student travel awardees. Each was assigned sessions as rapporteurs. This manuscript represents topics covered in most, but not all, oral presentations during the conference, and some of the major notable new findings reported at this 2012 WCPG. © 2013 Wiley Periodicals, Inc.
Efficient Simmons–Smith cyclopropanation with Zn/Cu and CH2I2
Authors: Fujii Kanami , Shiine Kodai , Misaki Tomonori , Sugimura Takashi
Published: January 2013

An appropriate solvent to perform the original Simmons–Smith reaction was reinvestigated. Among available solvents, cyclopentyl methyl ether (CPME), a recently commercialized ethereal solvent, was found to be the best so far. Compared with Et2O under reflux – the commonest conditions – reaction completion in CPME at 50 °C was about 10 times faster. The product yields and selectivities were mostly identical to those with Et2O, but were better in some cases; e.g. 13–56% with 2‐cyclohexenol. The good performance of CPME should be mainly due to its moderate polarity and high boiling point. Copyright © 2012 John Wiley & Sons, Ltd.
Synthesis and pyrolysis of a novel preceramic polymer PZMS from PMS to fabricate high‐temperature‐resistant ZrC/SiC ceramic composite
Authors: Wang Hao , Gao Bo , Chen Xingbo , Wang Jun , Chen Shugang , Gou Yanzi
Published: January 2013

As a valuable ultra‐high‐temperature ceramic (UHTC), ZrC was introduced to SiC ceramic for the preparation of high‐temperature‐resistant ZrC/SiC composite by a polymer‐derived method through the reaction between Cp2Zr(CH=CH2)2 and polymethylsilane (PMS). The composition, structure, element distribution and pyrolysis process of the preceramic polymer polyzirconomethylsilane (PZMS) were investigated by nuclear magnetic resonance, infrared, gel permeation chromatography, X‐ray photoelectron spectroscopy, energy‐dispersive X‐ray spectroscopy, scanning electron microscopy and thermogravimetric analysis. The obtained ZrC/SiC ceramic composites had very good high‐temperature resistance with a weight loss of 7.1% after being subjected to temperatures ranging from 1200 to 2200°C, as the introduction of ZrC prevented the fast growth of crystalline β‐SiC. The ceramic composites prepared by this method were homogeneous with well‐distributed element components, and the ceramic yield reached as high as 78.4%. Copyright © 2013 John Wiley & Sons, Ltd.
Mechanical and thermal transmission properties of carbon nanofiber‐dispersed carbon/phenolic multiscale composites
Authors: Bhattacharyya Amitava , Rana Sohel , Parveen Shama , Fangueiro Raul , Alagirusamy Ramasamy , Joshi Mangala
Published: January 2013

The present article reports the development and characterization of carbon nanofiber (CNF)‐incorporated carbon/phenolic multiscale composites. Vapor‐grown CNFs were dispersed homogeneously in to phenolic resin using an effective dispersion route, and carbon fabrics were subsequently impregnated with the CNF‐dispersed resin to develop carbon fiber/CNF/phenolic resin multiscale composites. Mechanical and thermal transmission properties of multiscale composites were characterized. Elastic modulus and thermal conductivity of neat carbon/phenolic and multiscale composites were predicted and compared with the experimental results. It was observed that incorporation of only 1.5 wt % CNF resulted in 10% improvement in Young's modulus, 12% increase in tensile strength, and 36% increase in thermal conductivity of carbon/phenolic composites. Fracture surface of composite samples revealed the formation of stronger fiber/matrix interface in case of multiscale composites than neat carbon/phenolic composites. Enhancement of above properties through CNF addition has been explained, and the difference between the predicted values and experimental results has been discussed. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Novel poly(ether ketone)arylates: Synthesis, characterization and properties
Authors: Zhou Yongxiang , Wang Ning , Li Min , Wu Lei , Wu Ting , Xu Jianjun , Liu Pengqing
Published: January 2013

In order to reduce the melt temperature (Tm) of the thermotropic crystalline polyarylate and improve its compatibility with poly(ether ether ketone) (PEEK), a series of poly(ether ketone)arylates (PEKARs) containing aryl ether ketone units (AEK) are synthesized through melt transesterification reaction from p‐acetoxybenzoic acid, 1,3‐bis(4′‐carboxylphenoxy)benzene and 4,4′‐bis(p‐acetoxyphenoxy)benzophenone. The inherent viscosities of these polymers are in the range 0.35–0.81 dL/g. The morphologies and properties of PEKARs are characterized by polarized optical microscopy, wide‐angle X‐ray diffraction, differential scanning calorimetry, thermal gravimetric analysis, etc. The results show that all PEKARs are semi‐crystalline polymers, and the introduction of AEK units can reduce the symmetry of the main chains, leading to decreasing the crystallizability and changing the crystalline form. The PEKARs with AEK less than 30% can exhibit thermotropic liquid crystalline state. The initial and the maximum decomposition temperatures increase with the increase in AEK content. These PEKARs are expected to act as processing agents for PEEK to reduce its processing viscosity. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Urethane reaction kinetics of butanediols catalyzed by Zr(acac)4
Authors: Yang Peng Fei , Li Tian Duo
Published: January 2013

The urethane reaction of isocyanate was carried out with zirconium acetyl acetonate (Zr(acac)4) as catalyst. 1,2‐Butanediol and 1,4‐butanediol were used as model compounds to investigate the reaction kinetics. It was shown that hydroxyl groups in 1,2‐butanediol appeared to have different reaction rate when reacting with phenyl isocyanate, which was labeled as kfast and kslow. It was very surprising that the reaction rate of 1,4‐butanediol (kcon) was very similar to the value of kslow at the same temperature although there is only primary hydroxyl group in its molecule. Furthermore, activation energy (Ea), activation enthalpy (ΔH), and activation entropy (ΔS) for the reaction were calculated out, from which some catalytic properties of Zr(acac)4 were revealed. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Turn‐On Fluorescence Detection of Apoptotic Cells Using a Zinc(II)‐Dipicolylamine‐Functionalized Poly(diacetylene) Liposome
Authors: Cho Yong‐Suk , Kim Kyung Mi , Lee Duhwan , Kim Won Jong , Ahn Kyo Han
Published: January 2013

A liposome‐based fluorescence sensing system for apoptotic cells has been developed from stimuli‐responsive poly(diacetylene)‐liposomes for the first time. The combination of the liposome components, a phosphatidylserine‐binding ZnII‐dipicolylamine component and an alcohol‐terminated component in the ratio of 2:1, has led to an efficient detection system for apoptotic cells, as demonstrated by confocal fluorescence microscopy and FACS analysis. The liposome shows a color change from blue to reddish purple and emits fluorescence in the turn‐on mode upon interaction with phosphatidylserine. The present system thus avoids the washing steps required for “always‐on”‐type sensing systems.
Assembling viral channel forming proteins: Vpu from HIV‐1
Authors: Li Li‐Hua , Hsu Hao‐Jen , Fischer Wolfgang B.
Published: January 2013

Different routes of assembly are probed for the transmembrane domain (TMD) of the bitopic membrane protein Vpu from HIV‐1. Vpu is responsible for the amplification of viral release from the host cell. The mode of action includes (i) heteroassembly with host factors and (ii) the formation of homo‐oligomers, which are able to conduct ions across the lipid membrane. Two different routes of assembling short sequences of the N terminus, including the TMD of Vpu, Vpu1–32, and Vpu8–26, are presented by using a combination of classical molecular dynamics (MD) simulations combined with a docking approach. The rim of alanines (Ala‐8, ‐11, ‐15, and ‐19) resembles an interlocking motif for the sequential assembly into a dimer and trimer. Simultaneous assembly results in oligomeric bundles (trimers to pentamers) with either tryptophans (Trp‐23) or purely hydrophobic residues facing the center. Bundles, with serines facing the pore (Ser‐24), are energetically not the lowest structures. For pentameric bundles with Ser‐24 facing the pore, no water column develops during a short 25 ns MD simulation. © 2013 Wiley Periodicals, Inc. Biopolymers 99: 517–529, 2013.
Liquid chromatography–tandem mass spectrometric assay for the determination of tetrabenazine and its active metabolites in human plasma: a pharmacokinetic study
Authors: Derangula Venkata Ramu , Pilli Nageswara Rao , Nadavala Siva Kumar , Adireddy Vinayender , Inamadugu Jaswanth Kumar , Ponneri Venkateswarlu
Published: January 2013

A simple, rapid and sensitive liquid chromatography–tandem mass spectrometric (LC‐MS/MS) assay method has been developed and fully validated for the simultaneous quantification of tetrabenazine and its active metabolites α‐dihydrotetrabenazine and β‐dihydrotetrabenazine in human plasma. Tetrabenazine d7 was used as internal standard (IS). The analytes were extracted from 200 μL aliquots of human plasma via solid‐phase extraction using C18 solid‐phase extraction cartridges. The reconstituted samples were chromatographed on a Zorbax SB C18 column using a 60:40 (v/v) mixture of acetonitrile and 5 mm ammonium acetate as the mobile phase at a flow rate of 0.8 mL/min. The API‐4000 LC‐MS/MS in multiple reaction‐monitoring mode was used for detection. The calibration curves obtained were linear (r2 ≥ 0.99) over the concentration range of 0.01–5.03 ng/mL for tetrabenazine and 0.50–100 ng/mL for α‐dihydrotetrabenazine and β‐dihydrotetrabenazine. Method validation was performed as per Food and Drug Administration guidelines and the results met the acceptance criteria. The method is precise and sensitive enough for its intended purpose. A run time of 2.5 min for each sample made it possible to analyze more than 300 plasma samples per day. The proposed method was found to be applicable to clinical studies. Copyright © 2013 John Wiley & Sons, Ltd.
Valuing Structured Professional Judgment: Predictive Validity, Decision‐making, and the Clinical‐Actuarial Conflict
Authors: Falzer Paul R.
Published: January 2013

Structured professional judgment (SPJ) has received considerable attention as an alternative to unstructured clinical judgment and actuarial assessment, and as a means of resolving their ongoing conflict. However, predictive validity studies have typically relied on receiver operating characteristic (ROC) analysis, the same technique commonly used to validate actuarial assessment tools. This paper presents SPJ as distinct from both unstructured clinical judgment and actuarial assessment. A key distinguishing feature of SPJ is the contribution of modifiable factors, either dynamic or protective, to summary risk ratings. With modifiable factors, the summary rating scheme serves as a prognostic model rather than a classification procedure. However, prognostic models require more extensive and thorough predictive validity testing than can be provided by ROC analysis. It is proposed that validation should include calibration and reclassification techniques, as well as additional measures of discrimination. Several techniques and measures are described and illustrated. The paper concludes by tracing the limitations of ROC analysis to its philosophical foundation and its origin as a statistical theory of decision‐making. This foundation inhibits the performance of crucial tasks, such as determining the sufficiency of a risk assessment and examining the evidentiary value of statistical findings. The paper closes by noting a current effort to establish a viable and complementary relationship between SPJ and decision‐making theory. Copyright © 2013 John Wiley & Sons, Ltd.
Bayes and Base Rates: What Is an Informative Prior for Actuarial Violence Risk Assessment?
Authors: Harris Grant T. , Rice Marnie E.
Published: January 2013

Bayes' theorem describes an axiomatic relationship among marginal and conditional proportions within a single “experiment.” In many ways, it has been fruitful to greatly extend this idea to the task of drawing inferences from data much more generally. Commonly, what matters is how all prior knowledge is revised (or not) by new findings resulting in posterior (sometimes “subjective”) probabilities. And, to address many important problems, it is sensible to conceive of probability in such subjective terms. However, some commentators in the domain of violence risk assessment have assumed an analogous axiomatic relationship among marginals (i.e., priors in the form of base rates) observed in one study and conditionals (i.e., posteriors in the form of revised rates) expected in a separate study or assessment context. We present examples from our own research to suggest this assumption is generally unwarranted and ultimately an unaddressed empirical matter. Copyright © 2013 John Wiley & Sons, Ltd.
Frequency of palmaris longus absence and its association with other anatomical variations in the egyptian population
Authors: Raouf Hoda Abdel , Kader Ghada Abdel , Jaradat Ahmed , Dharap Amol , Fadel Raouf , Salem Abdel Halim
Published: January 2013

The palmaris longus (PL) is one of the most variable muscles in the human body. Racial differences in its variation have been documented. Several studies have attempted to correlate PL absence with other anatomical variations. This study was conducted to determine the prevalence of absence of PL, correlate it with gender and body side and to determine its association with other anatomical variations in the Egyptian population. The presence of PL was clinically determined in 386 Egyptians using the standard technique. All subjects were examined for the presence of the flexor digitorum superficialis (FDS) to the fifth finger. Allen's test was done to assess the completeness of the superficial palmar arch (SPA). The overall prevalence of absence of the PL in Egyptian subjects was 50.8%. There was no significant difference in PL absence with regard to the body side but a significant difference was seen as regards gender and when bilateral absence of PL was compared to its unilateral absence. Absence of FDS tendon to the fifth finger was seen in 1.3% subjects. There was no association between the absence of the FDS tendon to the fifth finger and either presence or absence of PL and also between the absence of PL and the incompleteness of SPA in both genders. In conclusion, the prevalence of absence of PL in the Egyptian population represents one of the highest rates of absence to be reported for this muscle, which is significantly different from that in other ethnic groups. Clin. Anat. 26:572–577, 2013. © 2013 Wiley Periodicals, Inc.
One is the loneliest number: A review of the ganglion impar and its relation to pelvic pain syndromes
Authors: Walters Andrew , Muhleman Mitchel , Osiro Stephen , Bubb Kathleen , Snosek Michael , Shoja Mohammadali M. , Tubbs R. Shane , Loukas Marios
Published: January 2013

The ganglion impar is often overlooked as a component of the sympathetic nervous system. Despite its obscurity, this ganglion provides a pathway for neurons by accommodating postganglionic sympathetics, visceral afferents, and somatic fibers traveling to and from the pelvis. Its classic anatomic location as described in the 1720's held up until recently, with the current literature now revealing a great deal of anatomical variability. This variation becomes important when the ganglion impar is used as a treatment target for patients with chronic pelvic pain – its primary clinical implication. The aim of this review was to provide a better understanding of the anatomy of ganglion impar, accounting for variation in size, shape, and location. In addition, the clinical importance and treatment modalities associated with the ganglion impar are outlined. Clin. Anat. 26:855–861, 2013. © 2013 Wiley Periodicals, Inc.
Influence of edentulism on human orbit and zygomatic arch shape
Authors: Williams Shanna E. , Slice Dennis E.
Published: January 2013

Edentulism, or tooth loss, seriously alters the appearance of the lower facial skeleton. The aim of this study was to determine if complete maxillary edentulism also impacts the curvature shape of the orbits and zygomatic arches in elderly adults. The study was conducted on 80 crania comprising two cross‐sectional populations of elderly African‐ and European‐Americans (60–80 years old). Forty of the crania possessed intact dentition; the remaining 40 exhibited complete edentulism with tooth socket resorption. Three‐dimensional semilandmarks representing the curvature of the orbits and zygomatic arches were collected using a hand‐held digitizer. Each craniofacial region's semilandmarks were aligned into a common coordinate system via generalized Procrustes superimposition. Regional variation in shape was explored via principal component analysis, multivariate analysis of variance, discriminant function analysis, cross‐validation, and vector plots. Shape differences between the edentulous and dentate groups were detected in both the orbits (P = 0.0022) and zygomatic arches (P = 0.0026). Ancestry and sex differences were also identified in both regions. Orbit data correctly classified dentate crania 65% of the time and edentulous crania 72.5% of the time. Zygomatic arch data correctly classified 75% dentate and 60% of edentulous crania. The individual curves constituting each region also exhibited shape alteration with tooth loss, with the exception of the inferior zygomatic curve. Vector plots revealed patterns of superoinferior expansion, and medial and lateral recession depending on the region examined. These results suggest a relationship exists between maxillary edentulism and changes in the surrounding craniofacial structures. Clin. Anat. 27:408–416, 2014. © 2013 Wiley Periodicals, Inc.
Chemical Variability of Algerian Myrtus communis L.
Authors: Bouzabata Amel , Castola Vincent , Bighelli Ange , Abed Lahouari , Casanova Joseph , Tomi Félix
Published: January 2013

The composition of 55 samples of essential oil isolated from the aerial parts of wild growing Myrtus communis L. harvested in 16 locations from East to West Algeria were investigated by GC (determination of retention indices) and 13C‐NMR analyses. The essential oils consisted mainly of monoterpenes, α‐pinene (27.4–59.2%) and 1,8‐cineole (6.1–34.3%) being the major components. They were also characterized by the absence of myrtenyl acetate. The compositions of the 55 oils were submitted to k‐means partitioning and principal component analysis, which allowed the distinction of two groups within the oil samples, which could be subdivided into two subgroups each. Groups I (78% of the samples) and II were differentiated on the basis of the contents of α‐pinene, linalool, and linalyl acetate. Subgroups IA and IB could be distinguished by their contents of α‐pinene and 1,8‐cineole. Subgroups IIA and IIB differed substantially in their contents of 1,8‐cineole and limonene. All the samples contained 3,3,5,5,8,8‐hexamethyl‐7‐oxabicyclo[4.3.0]non‐1(6)‐ene‐2,4‐dione (up to 4.9%).
Effect of Initial Temperature on Water Aggregation at a Cold Surface
Authors: Kier Lemont B. , Cheng Chao‐Kun
Published: January 2013

Cellular automata models of water at two initial temperatures were created. Each model was exposed to a freezing surface. The formation of fully bonded water cells, f4, was observed over time, beginning with a model of initially warm water and with initially cool water. The warm water formed more f4 cells earlier than the initially cool water. A high percentage of f4 cells is interpreted as the formation of ice. This is a model of the Mpemba effect. A description of the initial states for these two temperatures is offered in explanation of this effect.
Variability of the Needle Essential Oils of Juniperus deltoides R.P.Adams from Different Populations in Serbia and Croatia
Authors: Rajčević Nemanja , Janaćković Peđa , Bojović Srđan , Tešević Vele , Marin Petar D.
Published: January 2013

The essential‐oil compositions of one Croatian and three Serbian populations of Juniperus deltoides R.P.Adams have been determined by GC/MS analysis. In total, 147 compounds were identified, representing 97.3–98.3% of the oil composition. The oils were dominated by monoterpenes, which are characteristic components for the species of the section Juniperus. Two monoterpenes, α‐pinene and limonene, were the dominant constituents, with a summed‐up average content of 49.45%. Statistical methods were used to determine the diversity of the terpene classes and the common terpenes between the newly described J. deltoides populations from Serbia and Croatia. Only reports on several specimens from this species have been reported so far, and there are no studies that treat population diversity. Cluster analysis of the oil contents of 21 terpenes showed high correlation with the geographical distribution of the populations, separating the Croatian from the Serbian populations. The comparison of the essential‐oil compositions obtained in the present study with literature data, showed the separation of J. deltoides and J. oxycedrus ssp. oxycedrus from the western Mediterranean region.
Enhancing Oxidative Dehydrogenation Selectivity of Ceria‐Based Catalysts with Phosphorus as Additive
Authors: Trotuş Ioan‐Teodor , Teodorescu Cristian M. , Pârvulescu Vasile I. , Marcu Ioan‐Cezar
Published: January 2013

Surface‐ and bulk‐phosphated ceria catalysts were prepared and studied in propane oxidative dehydrogenation (ODH) at 823 and 873 K. The catalysts were characterized by N2 adsorption at 77 K, XRD, TEM, and diffuse reflectance IR Fourier transform (DRIFT), Raman, X‐ray photoelectron (XPS), and energy dispersive X‐ray (EDX) spectroscopies. Both series of catalysts presented an increase in the ODH selectivity with respect to pure ceria mainly at the expense of total oxidation selectivity. Thus, the selectivity to propene was approximately 74 % with surface‐phosphated catalysts and 62 % with bulk‐phosphated catalysts. For the surface‐phosphated samples, P is confined to the surface and subsurface regions of the ceria particles, whereas P is also dispersed in the bulk of the oxide in the bulk‐phosphated samples. Finally, all the characterization techniques led us to the conclusion that Ce4+ cations that interact with P are responsible for the observed increase in the ODH.
Effect of Temperature on Controlled Air Oxidation of Plastic and Biomass in a Packed‐Bed Reactor
Authors: Meng Q.‐M. , Chen X.‐P. , Zhuang Y.‐M. , Liang C.
Published: January 2013

A packed‐bed reactor was established to study the effect of temperature on the controlled air oxidation (CAO) performance of a mixture of polypropylene and sawdust at a fixed feed gas flow rate. The reactor temperature was varied from 400 to 800 °C. Attention was focused on product distribution, compositions of liquid and gas products, and technical parameters. The chemical composition of the liquid products was analyzed by gas chromatography/mass spectrometry. The results indicated an obvious impact of the temperature on the described parameters. The increase in temperature led to the decrease in solid fraction and a convex shape curve for the gas yield as well as to a decrease of alkanes and alkenes, and favored the generation of oxygen‐containing hydrocarbons. According to criteria of CAO conversion, the optimum temperature in the primary chamber was found to be 700 °C.
Am(m)ines Make the Difference: Organoruthenium Am(m)ine Complexes and Their Chemistry in Anticancer Drug Development
Authors: Babak Maria V. , Meier Samuel M. , Legin Anton A. , Adib Razavi Mahsa S. , Roller Alexander , Jakupec Michael A. , Keppler Bernhard K. , Hartinger Christian G.
Published: January 2013

With the aim of systematically studying fundamental structure–activity relationships as a basis for the development of RuII arene complexes (arene=p‐cymene or biphenyl) bearing mono‐, bi‐, or tridentate am(m)ine ligands as anticancer agents, a series of ammine, ethylenediamine, and diethylenetriamine complexes were prepared by different synthetic routes. Especially the synthesis of mono‐, di‐, and triammine complexes was found to be highly dependent on the reaction conditions, such as stoichiometry, temperature, and time. Hydrolysis and protein‐binding studies were performed to determine the reactivity of the compounds, and only those containing chlorido ligands undergo aquation or form protein adducts. These properties correlate well with in vitro tumor‐inhibiting potency of the compounds. The complexes were found to be active in anticancer assays when meeting the following criteria: stability in aqueous solution and low rates of hydrolysis and binding to proteins. Therefore, the complexes least reactive to proteins were found to be the most cytotoxic in cancer cells. In general, complexes with biphenyl as arene ligand inhibited the growth of tumor cells more effectively than the cymene analogues, consistent with the increase in lipophilicity. This study highlights the importance of finding a proper balance between reactivity and stability in the development of organometallic anticancer agents.
Co‐Conformational Isomerism in a Neutral Ion‐Paired Supramolecular System
Authors: Cervantes Ruy , Sánchez Raul I. , Tiburcio Jorge
Published: January 2013

Two different counter‐ion‐free host–guest complexes have been prepared and isolated. These compounds were formed from two equally and opposite doubly‐charged species, the viologen guests 1 a2+ and 1 b2+ and the anti‐disulfodibenzo[24]crown‐8 [DSDB24C8]2− host, which gave rise to the 1:1 neutral complexes [1 a⋅DSDB24C8] and [1 b⋅DSDB24C8]. These species are held together by hydrogen bonding and π stacking, as well as strong electrostatic interactions. The investigation of these neutral ion‐paired supramolecular systems in solution and in the solid state allowed us to establish their co‐conformational preferences. Compound [1 a⋅DSDB24C8], with small methyl groups as substituents on the viologen unit, may adopt three different geometries, 1) an exo nonthreaded, 2) a partially threaded, and 3) a threaded arrangement, depending on the relative spatial orientation between the host and guest: The partially‐threaded structure is preferred in solution and in the solid state. The presence of bulky tert‐butylbenzyl groups in the viologen moiety in compound [1 b⋅DSDB24C8] restricts the possible geometrical arrangements to one: The exo nonthreaded arrangement. This structure was confirmed in the solid state by X‐ray crystallography. The stability of the neutral complexes in solution was determined by UV/Vis spectrophotometry. The stoichiometry of the complexes was established by continuous variation experiments, and overall equilibrium constants and ΔG° values were determined on the basis of dilution experiments. The results observed are a consequence of only the intrinsic stability of the complexes as there are no additional contributions from counter ions.
ChemInform Abstract: Crystal Structure and Vibrational Properties of a Sodium Oxoferrate(II) Hydroxide, Na5[FeO3][OH].
Authors: Gheorghe Dana E. , Litvinchuk Alexander P. , Moeller Angela
Published: January 2013

Red crystals of the title compound are prepared by reaction of Na2O, Fe, CdO, and NaOH (Ag container, argon, 450 °C, 5 d).
ChemInform Abstract: Facile Fabrication of Bi2O3/Bi—NaTaO3 Photocatalysts for Hydrogen Generation under Visible Light Irradiation.
Authors: Reddy K. Hemalata , Martha Satyabadi , Parida K. M.
Published: January 2013

Bi2O3/Bi—NaTaO3 photocatalysts are prepared by solid state reaction of Bi(NO3)3, Ta2O5, and Na2C2O4 using urea as complexing agent and fuel (600 °C, 4 h).
ChemInform Abstract: The Zintl Phases Eu3Mg5Si5 and Eu3Mg5Ge5.
Authors: Schellenberg Inga , Eul Matthias , Schwickert Christian , Kubata Christof M. , Cuervo Reyes Eduardo , Nesper Reinhard , Rodewald Ute Ch. , Poettgen Rainer
Published: January 2013

The Zintl phases of title are prepared by high‐frequency melting of the elements (Ta tubes, 800 mbar argon, 1280 K for 10 min and 1080 K for3 h).
ChemInform Abstract: New Thiostannates Synthesized under Solvothermal Conditions: Crystal Structures of (trenH)2Sn3S7 and {[Mn(tren)]2Sn2S6}.
Authors: Pienack Nicole , Schinkel Diana , Puls Angela , Ordolff Marie‐Eve , Luehmann Henning , Naether Christian , Bensch Wolfgang
Published: January 2013

The new compounds (II) and (IV) are solvothermally synthesized and their crystal structures are determined by single crystal XRD.
ChemInform Abstract: Crystal Structure and Electronic Structure of Red SnO.
Authors: Koehler Juergen , Tong Jianwei , Dinnebier Robert , Simon Arndt
Published: January 2013

Ruby‐red powder samples of SnO are obtained from a freshly prepared acidic SnCl2 solution containing H3PO3 by adjusting the pH value to 4.9 (dropwise addn.
ChemInform Abstract: Uranyl Halides from Liquid Ammonia: [UO2(NH3)5] Cl2·NH3 and [UO2F2(NH3)3] 2·2NH3 and Their Decomposition Products [UO2Cl2(NH3)3] and [UO2F2(NH3)3].
Authors: Woidy Patrick , Karttunen Antti J. , Kraus Florian
Published: January 2013

The crystal structures of the green compound (II) and the yellow compound (IV) are determined by single crystal XRD.
ChemInform Abstract: The Trivalent Manganese Hydrogenophosphate LiMn(H2P2O7)2: A Chain‐Like Structure.
Authors: Baies Radu , Pralong Valerie , Caignaert Vincent , Raveau Bernard
Published: January 2013

The new MnIII compound of title is prepared by addition of Li2CO3 to a hot (250 °C) solution of Mn2O3 in conc.
ChemInform Abstract: Synthesis and Crystal Structure of the Highly Reduced Metalate Ba3[Ir(CN)3].
Authors: Jach Franziska , Hoehn Peter , Senyshyn Anatoliy , Ruck Michael , Kniep Ruediger
Published: January 2013

The title compound is synthesized by solid state reaction of Ba2N, Ir, NaCN, and graphite (pressed pellets, Ta ampules, argon, 1020 K, 24 h).
ChemInform Abstract: (3R,4R)‐2,2,5,5‐Tetraphenyltetrahydrofuran‐3,4‐diol Assisted, L‐Proline‐Catalyzed Michael Addition of Acetone to Nitroalkenes.
Authors: Hu Xiaoyun , Shan Zixing , Qing Chang
Published: January 2013

Addition of catalytic amounts of the chiral title furandiol (TPF) in the proline‐catalyzed Michael addition of acetone to nitroalkenes results in a significant improvement of the enantioselectivity.
ChemInform Abstract: Palladium(II)‐Catalyzed Tandem Cyclization of Electron‐Deficient Aromatic Enynes.
Authors: Wu Na , Messinis Antonios , Batsanov Andrei S. , Yang Zhen , Whiting Andrew , Marder Todd B.
Published: January 2013

A novel one‐pot tandem cyclization of electron‐deficient aromatic enynes furnishing indenones or 6,5,6‐fused tricyclic lactones is developed.
ChemInform Abstract: Mixed Metal MgO—ZrO2 Nanoparticle‐Catalyzed O‐tert‐Boc Protection of Alcohols and Phenols under Solvent‐Free Conditions.
Authors: Gawande Manoj B , Shelke Sharad N. , Branco Paula S. , Rathi Anuj , Pandey Rajesh K.
Published: January 2013

An environmentally benign, expedient, simple, and efficient protocol for the title reaction is described by using a novel, reusable, and chemoselective catalyst which can be easily prepared from inexpensive precursors.
ChemInform Abstract: Chemoselective Transfer Hydrogenation to Nitroarenes Mediated by Cubane‐Type Mo3S4 Cluster Catalysts.
Authors: Sorribes Ivan , Wienhoefer Gerrit , Vicent Cristian , Junge Kathrin , Llusar Rosa , Beller Matthias
Published: January 2013

A wide range of aromatic and heteroaromatic nitro‐compounds is reduced to the corresponding amines using formates as reducing agent.
ChemInform Abstract: Indium‐Mediated Aza‐Henry Reaction of Imines: Access to 2‐Nitroamines.
Authors: Soengas Raquel G. , Silva Sandrina , Estevez Amalia M. , Estevez Juan C. , Estevez Ramon J. , Rodriguez‐Solla Humberto
Published: January 2013

A new method for the synthesis of the title compounds is developed.
ChemInform Abstract: Regioselective Synthesis of 1,2‐Amino Alcohols from Epoxides and Chlorohydrins.
Authors: Murugan Andiappan , et al. et al.
Published: January 2013

The simple protocol uses NaN(Tms)2 as the source of amine.
ChemInform Abstract: Highly Efficient Asymmetric Michael Addition Reaction of Malonates to α,β‐Unsaturated Ketones Promoted by a Chiral Thiourea/PPY Dual‐Catalyst System.
Authors: Moritaka Maya , Miyamae Naomu , Nakano Keiji , Ichikawa Yoshiyasu , Kotsuki Hiyoshizo
Published: January 2013

A new catalyst system is developed.
ChemInform Abstract: Heck Reaction of Baylis—Hillman Adducts with Iodobenzenes Using a Catalytic Amount of Pd/C under Solvent‐Free Conditions.
Authors: Kim Hyun‐Soo , Lee Sang‐Jin , Choi Boram , Yoon Cheol Min
Published: January 2013

The efficient process affords α‐benzyl‐β‐keto esters in generally high yields in the absence of any additive or solvent.
ChemInform Abstract: Catalyst‐Free Amidation of Trimethylsilyl Ketene Imines with Isocyanates.
Authors: Qin Wenling , Long Sha , Panunzio Mauro , Bongini Alessandro
Published: January 2013

The silyl ketimines, generated in situ from diarylmethane nitriles and TmsCl via lithiation, undergo a non‐catalyzed reaction with isocyanates to give highly substituted malonamides in moderate yields.
ChemInform Abstract: Dramatic Solvent Effect in the One‐Pot Synthesis of Substituted Ureas Directly from Primary Alcohols Using the Combined Reagent of Iodobenzene Dichloride and Sodium Azide in Ethyl Acetate.
Authors: Zhang Chi , Wang Wei‐Kun , He Tian
Published: January 2013

Compare to MeCN, previously used in similar procedures, ethyl acetate is found to be the optimal solvent for the conversion of benzylic alcohols into carbamoyl azides.
ChemInform Abstract: High‐Pressure‐Promoted Diels—Alder Approach to Biaryls: Application to the Synthesis of the Cannabinols Family.
Authors: Minuti Lucio , Temperini Andrea , Ballerini Eleonora
Published: January 2013

The procedure can be applied to the synthesis of benzochromenones and cannabiols.
ChemInform Abstract: Phase‐Transfer Catalysts in the O‐Alkylation of 2‐Hydroxynaphthoquinones.
Authors: Lu Xiao , Altharawi Ali , Hansen Emily N. , Long Timothy E.
Published: January 2013

A mild procedure for the selective alkylation of the substrates at the 2‐hydroxy group is developed using a mixture of two phase‐transfer catalysts.
ChemInform Abstract: Synthesis of 3,4‐Dihalogenated Furan‐2‐(5H)‐ones by Electrophilic Cyclization of 4‐Hydroxy‐2‐alkynoates.
Authors: Zhu Hai‐Tao , Wang Li‐Jing , Ji Ke‐Gong , Liu Xue‐Yuan , Liang Yong‐Min
Published: January 2013

An efficient synthesis of the title compounds (II), (III), or (IV) is described.
ChemInform Abstract: Electrophilic Cyclization of 2‐(2′,3′‐Allenyl)acetylacetates with Iodine Using Calcium Hydride as the Base.
Authors: Wan Baoqiang , Jiang Xuefeng , Jia Guochen , Ma Shengming
Published: January 2013

A rapid, facile, scalable, and efficient protocol for the title reaction is developed.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Synthesis of 2‐Pyrrolidinones with a Quaternary Carbon Stereocenter.
Authors: Shintani Ryo , Ito Tomoaki , Nagamoto Midori , Otomo Haruka , Hayashi Tamio
Published: January 2013

A novel chiral phosphoramidite ligand is prepared and successfully applied in the palladium‐catalyzed reaction of lactones (I) with isocyanates.
ChemInform Abstract: Synthesis of Bis(indolyl)methanes Using Silica Gel as an Efficient and Recyclable Surface.
Authors: Mendes Samuel R. , Thurow Samuel , Fortes Margiani P. , Penteado Filipe , Lenardao Eder J. , Alves Diego , Perin Gelson , Jacob Raquel G.
Published: January 2013

A simple solvent‐free protocol is developed.
ChemInform Abstract: Catalyst‐Free N‐Arylation Using Unactivated Fluorobenzenes.
Authors: Diness Frederik , Fairlie David P.
Published: January 2013

The new valuable, very simple, rapid, and versatile title reaction tolerates a wide range of substituents.
ChemInform Abstract: Effect of Microwave Irradiation on the Synthesis of 1,2,4‐Triazol‐3‐one Derivatives and Their Antimicrobial Activities.
Authors: Kahveci Bahittin , Yilmaz Fatih , Mentese Emre , Beris Fatih Saban
Published: January 2013

An efficient and easy method for the synthesis of triazolone derivatives (III) and their conversion into 5‐mercapto‐1,3,4‐oxadiazole derivatives (VIII) using microwave chemistry is described.
ChemInform Abstract: Some Novel Oxadiazolyl/Azetidinyl Benzimidazole Derivatives: Synthesis and in vitro Biological Evaluation.
Authors: Ansari K. F. , Lal C. , Parmar D. L.
Published: January 2013

Various oxadiazolyl‐(X) and azetidinyl‐derivatives (XIV) of benzimidazole are synthesized and evaluated for their antibacterial activity.
ChemInform Abstract: One‐Pot Synthesis of 5‐Acyl‐2‐amino‐1,3,4‐thiadiazoles.
Authors: Lindstroem Johan , Hallberg Jesper
Published: January 2013

The easy two‐step procedure allows a rapid approach to the biologically important heterocyclic scaffold.
ChemInform Abstract: Synthesis of (1H)‐Isochromen‐1‐imines by Nickel‐Catalyzed Reaction of 2‐Iodobenzamides with Alkynes.
Authors: Miura Tomoya , Hiraga Kentaro , Toyoshima Takeharu , Yamauchi Motoshi , Murakami Masahiro
Published: January 2013

The reaction of 2‐iodobenzamide (I) and 3‐iodoacrylamide (VIII), respectively with alkynes in the presence of a nickel(0) catalyst with various ligands is studied.
ChemInform Abstract: Catalytic Coupling of Arene C—H Bonds and Alkynes for the Synthesis of Coumarins: Substrate Scope and Application to the Development of Neuroimaging Agents.
Authors: Vadola Paul A. , Sames Dalibor
Published: January 2013

PtCl4 and AuCl(PPh3)/ AgSbF6 efficiently promote the intramolecular hydroarylation of alkynoates, thus allowing formation of various coumarin derivatives.
ChemInform Abstract: An Expeditious Synthesis of cis‐2‐(Aroylmethyl)‐4‐phenylthiochromans by Iodine‐Catalyzed Combination of Thiophenol with Cinnamylideneacetophenones.
Authors: Mallik Asok K. , Mandal Tapas K. , Pal Rammohan , Ghosal Debojyoti , Patra Amarendra
Published: January 2013

A simple method is presented for the stereoselective synthesis of a new family of biologically interesting thiochroman derivatives.
ChemInform Abstract: Catalytic Asymmetric [4 + 2] Annulation Initiated by an Aza‐Rauhut—Currier Reaction: Facile Entry to Highly Functionalized Tetrahydropyridines.
Authors: Shi Zugui , Yu Peiyuan , Loh Teck‐Peng , Zhong Guofu
Published: January 2013

Aminophosphine catalyst derived from a natural amino acid is applied to catalyze the title reaction affording enantioenriched tetrahydropyridines in high dia‐ and enantioselectivities.
ChemInform Abstract: A Facile and Convenient Synthesis of Novel Pyridine Derivatives Incorporating Antipyrine Moiety and Investigation of Their Antimicrobial Activities.
Authors: Kheder Nabila A. , Riyadh Sayed M. , Asiry Ahlam M.
Published: January 2013

Title compounds (III) and (V) are synthesized starting from acetamide (I).
ChemInform Abstract: Preparation of N‐Alkyl 2‐Pyridones via a Lithium Iodide Promoted O‐ to N‐Alkyl Migration: Scope and Mechanism.
Authors: Tasker Sarah Z. , Bosscher Michael A. , Shandro Christina A. , Lanni Erica L. , Ryu Keun Ah , Snapper Gregory S. , Utter Jarrad M. , Ellsworth Bruce A. , Anderson Carolyn E.
Published: January 2013

In the presence of LiI, a number of 2‐benzyloxy‐, 2‐allyloxy‐, and 2‐propargyloxypyridines undergoes efficient migration to afford N‐alkylated 2‐pyridones.
ChemInform Abstract: Enantioselective Organocatalytic Domino Synthesis of Tetrahydropyridin‐2‐ols.
Authors: Wan Jie‐Ping , Loh Charles C. J. , Pan Fangfang , Enders Dieter
Published: January 2013

A series of tetrahydropyridin‐2‐ols (III) is obtained by a Michael addition‐hemiaminalization reaction sequence of enaminones (I) with enals (II).
ChemInform Abstract: Oxidative Addition of Heteroaromatic Halides to Negishi Reagent and Subsequent Cross‐Coupling Reactions.
Authors: Harris Caleb F. , Ravindranathan Deepak , Huo Shouquan
Published: January 2013

Heteroarylzirconocene halides such as (II), generated in situ, are found to be excellent coupling partners in reactions with functionalized aryl and heteroaryl halides.
ChemInform Abstract: Al‐Catalyzed Facile Construction of Quaternary C—C Bonds by the Allylic Substitution of Tertiary Alcohols: A Concise and Formal Synthesis of (.+‐.)‐Mersicarpine.
Authors: Zhong Xue , Li You , Han Fu‐She
Published: January 2013

Tricyclic tertiary alcohol (I) is efficiently prepared in a very atom‐efficient manner in three steps from indole and succinic anhydride via acyclation of indole with the anhydride, Friedel—Crafts acylation of the resulting indole carboxylic acid to give the tricycle, and final Grignard reaction to install the tertiary alcohol.
ChemInform Abstract: Concise [4 + 3] Cycloaddition Reaction of Pyrroles Leading to Tropinone Derivatives.
Authors: Fuchigami Ryuichi , Namba Kosuke , Tanino Keiji
Published: January 2013

2‐(Silyloxy)allyl cations, stabilized with a methylthio function or geminal methyl groups, are generated in situ from the corresponding allylic alcohols.
ChemInform Abstract: Synthesis, Characterization, and Tuberculostatic Activity of Novel Heterocyclic Compounds Derived from Dimethyl Heteroaroylcarbonohydrazonodithioates.
Authors: Gobis Katarzyna , Foks Henryk , Augustynowicz‐Kopec Ewa , Napiorkowska Agnieszka
Published: January 2013

Most of the obtained compounds exhibit low activity in vitro towards M.
ChemInform Abstract: Discovery and Application of Iminotriphenylphosphorane as a Formal Aromatic Primary Amine Protecting Group.
Authors: Delouvrie Benedicte , Germain Herve , Harris Craig S. , Lamorlette Maryannick , Lebraud Honorine , Nguyen Ha Thi Hoang , Noisier Anais , Ouvry Gilles
Published: January 2013

An application of the protection group to the synthesis of benzotriazoles and triazoles is developed and extended to other products such as (VIII) and (X).