bluuebunny/crossref_metadata_2025 huggingface dataset:
Leak-Off Pressure Using Weakly Correlated Geospatial Information and Machine Learning Algorithms
Authors: Choi Jung Chan , Liu Zhongqiang , Lacasse Suzanne , Skurtveit Elin
Published: April 2021

Leak-off pressure (LOP) is a key parameter to determine the allowable weight of drilling mud in a well and the in situ horizontal stress. The LOP test is run in situ and is frequently used by the petroleum industry. If the well pressure exceeds the LOP, wellbore instability may occur, with hydraulic fracturing and large mud losses in the formation. A reliable prediction of LOP is required to ensure safe and economical drilling operations. The prediction of LOP is challenging because it is affected by the usually complex earlier geological loading history, and the values of LOP and their measurements can vary significantly geospatially. This paper investigates the ability of machine learning algorithms to predict leak-off pressure on the basis of geospatial information of LOP measurements. About 3000 LOP test data were collected from 1800 exploration wells offshore Norway. Three machine learning algorithms (the deep neural network (DNN), random forest (RF), and support vector machine (SVM) algorithms) optimized by three hyperparameter search methods (the grid search, randomized search and Bayesian search) were compared with multivariate regression analysis. The Bayesian search algorithm needed fewer iterations than the grid search algorithms to find an optimal combination of hyperparameters. The three machine learning algorithms showed better performance than the multivariate linear regression when the features of the geospatial inputs were properly scaled. The RF algorithm gave the most promising results regardless of data scaling. If the data were not scaled, the DNN and SVM algorithms, even with optimized parameters, did not provide significantly improved test scores compared to the multivariate regression analysis. The analyses also showed that when the number of data points in a geographical setting is much smaller than that of other geographical areas, the prediction accuracy reduces significantly.
Successful Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19 (PIMS-TS) with Split Doses of Immunoglobulin G and Estimation of PIMS-TS Incidence in a County District in Southern Germany
Authors: Wehl Götz , Franke Jörg , Frühwirth Martin , Edlinger Michael , Rauchenzauner Markus
Published: April 2021

Pediatric inflammatory multisystem syndrome temporally associated with SARS Cov2 (PIMS-TS) is a newly encountered disease in children sharing clinical features with Kawasaki disease, toxic shock syndrome, or macrophage-activating syndrome. Pathogenically, it is associated with immune-mediated post-infectious hyperinflammation leading to short-term myocardial injury with yet unknown long-term outcome. We herein present three cases of PIMS-TS treated in our institution with divided doses of immunoglobulins and high dose acetyl salicylic acid, according to existing Kawasaki disease guidelines. Due to greater weight in adolescents affected and concerns of rheological sequelae following possible hyperviscosity, doses of immunoglobulins were divided and given 24 h apart with good tolerability. All patients recovered rapidly with normalization of previously encountered cardiac manifestations. As diagnosis of PIMS-TS should be made promptly, timing of therapy is of paramount importance for a favorable outcome. To date, no randomized controlled trial data exist concerning treatment recommendations. 1.8% (95% CI: 1.7% to 2.0%) of all children and adolescents in the county district of Ostallgäu were tested positive for SARS CoV-2, incidence of PIMS-TS was 1.7% (95% CI: 0.9% to 3.1%) among SARS CoV-2 positive tested earlier. As the pandemic is still ongoing, rising numbers of PIMS-TS in children might be expected.
Relationships among the Degree of Participation in Physical Activity, Self-Concept Clarity, and COVID-19 Stress in Adolescents
Authors: Lee Dae-Jung
Published: April 2021

The COVID-19 pandemic situation threatens the health of people globally, especially adolescents facing mental problems such as depression, anxiety, and obsessive-compulsive disorder due to constant COVID-19 stress. The present study aimed to provide basic data highlighting the need to alleviate COVID-19 stress among adolescents by promoting physical activity participation and strengthening self-concept clarity (SCC). To examine the relationships among participation in physical activity, SCC, and COVID-19 stress in pandemic-like conditions, the study was conducted on middle and high school students aged 14 to 19 and an online survey was conducted on 1046 Korean adolescents (521 male and 525 female students in the preliminary survey and main survey). Frequency, reliability, confirmatory factor, descriptive, and path analyses were performed using SPSS and AMOS 18.0. Participation in physical activity exerted a positive effect on SCC (p < 0.001) as well as a negative effect on COVID-19 stress (p = 0.031). Our findings also indicated that SCC exerted a negative effect on COVID-19 stress (p < 0.001). Regular participation in physical activity and strong SCC are also fundamental elements for alleviating COVID-19 stress. Given these results, state and local governments and educational institutions should encourage youth to participate in sports by suggesting policies, providing guidelines, and offering education. Such information may allow adolescents to endure and overcome COVID-19 stress during this critical period of life.
A Transcriptomic Analysis of Gene Expression in Chieh-Qua in Response to Fusaric Acid Stress
Authors: Wang Min , Liu Wenrui , Yan Jinqiang , Sun Piaoyun , Chen Feng , Jiang Biao , Xie Dasen , Lin Yu’e , Peng Qingwu , He Xiaoming
Published: April 2021

Fusarium wilt results in undesirable effects on the quality and production of chieh-qua (Benincasa hispida Cogn. var. Chieh-qua How). Fusaric acid (FA), a secondary metabolite of biotin produced by pathogens of genus Fusarium, induced resistant responses in chieh-qua; however, the physiological and molecular mechanism(s) of FA resistance remains largely unknown. In our study, ‘A39’ (FA-resistant cultivar) exhibited decreased malondialdehyde (MDA) content and increased superoxide dismutase (SOD) enzyme activity when exposed to FA compared with ‘H5’ (FA-susceptible cultivar). More apoptosis cells existed in ‘H5’ than ‘A39’ after 2 days of FA treatment. RNA-seq results revealed that a total of 2968 and 3931 differentially expressed genes (DEGs) were detected under normal conditions (1562 up-regulated and 1406 down-regulated) and FA treatment (2243 up-regulated and 1688 down-regulated), respectively. Interestingly, DEGs associated with pathogen-related protein and ethylene (ET) biosynthesis and signal pathways were most significantly changed during FA stress. Notably, several crucial genes encoding pathogenesis-related protein (CL4451.Contig2, CL2175.Contig4), peroxidase (Unigene49615 and CL11695.Contig2), and ET-responsive transcription factors (TFs) (CL9320.Contig1, CL9849.Contig3, CL6826.Contig2, CL919. Contig6, and CL518.Contig7) were specifically induced after FA treatment. Collectively, the study provides molecular data for isolating candidate genes involved in FA resistance, especially ET related genes in chieh-qua.
Factors Associated with the Implementation of Non-Pharmaceutical Interventions for Reducing Coronavirus Disease 2019 (COVID-19): A Systematic Review
Authors: Regmi Krishna , Lwin Cho Mar
Published: April 2021

There has been much discussion recently about the importance of implementing non-pharmaceutical interventions (NPIs) to protect the public from coronavirus disease 2019 (COVID-19) infection. Different governments across the world have adopted NPIs (e.g., social distancing, quarantine, isolation, lockdowns, curfews, travel restrictions, closures of schools and colleges). Two fundamental strategies, namely a strict containment strategy—also called suppression strategy—and a mitigation strategy have been adopted in different countries, mainly to reduce the reproduction number (R0) to below one and hence to reduce case numbers to low levels or eliminate human-to-human transmission, as well as to use NPIs to interrupt transmission completely and to reduce the health impact of epidemics, respectively. However, the adoption of these NPI strategies is varied and the factors impacting NPI are inconsistent and unclear. This study, therefore, aimed to review the factors associated with the implementation of NPIs (social distancing, social isolation and quarantine) for reducing COVID-19. Following PRISMA guidelines, we searched for published and unpublished studies, undertaking a systematic search of: MEDLINE, EMBASE, Allied and Complementary Medicine, COVID-19 Research, WHO database on COVID-19, and Google Scholar. Thirty-three studies were included in the study. Seven descriptive themes emerged on enablers and barriers to NPIs: the positive impact of NPIs, effective public health interventions, positive change in people’s behaviour and concerns about COVID-19, the role of mass media, physical and psychological impacts, and ethnicity/age associated with COVID-19. This study has highlighted that the effectiveness of NPIs in isolation is likely to be limited, therefore, a combination of multiple measures e.g., SD, isolation and quarantine, and workplace distancing appeared more effective in reducing COVID-19. Studies suggest that targeted approaches alongside social distancing might be the way forward, and more acceptable. Further research to promote country- and context-specific adoption of NPIs to deliver public health measures is needed. Studies comparing the effectiveness of interventions and strategies will help provide more evidence for future pandemics.
Correctional Work: Reflections Regarding Suicide
Authors: Genest Christine , Ricciardelli Rosemary , Carleton R. Nicholas
Published: April 2021

The Public Health Agency of Canada declared suicide a public health problem in Canada (2016). Employees working in correctional services, researchers find, experience high rates of life-time suicidal ideation in comparison to other public safety professionals and the general population. Suicide behaviours (i.e., ideation, planning, attempts, death) are a multifactorial phenomenon, explained in part by the Interpersonal-Psychological Theory of Suicide that suggests attempted suicide is facilitated by perceived burdensomeness, a lost sense of belonging, a feeling of hopelessness, and a progressively reduced fear of death, as well as capacity and planning to engage a lethal attempt. In the current study, we unpack the factors that can influence suicide behaviours as reported by correctional workers. Our intent is to make explicit the experiences of a small sample (n = 25) of correctional workers in relation to suicidal behaviours, highlighting stories of recovery and acknowledging the importance of facilitating psychologically safe workplaces. Analysis entailed an inductive semi-grounded emergent theme approach. Participants identified certain risk factors as being able to induce suicidal ideation, such as marital or family problems as well as difficulties at work (i.e., bullying or difficult working conditions). Having children and a partner may act as factors preventing suicide for those with ideation. Participants sought help from professionals, such as their family doctor, a psychologist, or the Employee Assistance Program (EAP); however, the lack of perceived organisational supports and recognition of the issue of suicide by the employer are two elements that can hinder the search for help.
Snapshot of the Use of Urban Green Spaces in Mexico City during the COVID-19 Pandemic: A Qualitative Study
Authors: Mayen Huerta Carolina , Cafagna Gianluca
Published: April 2021

The present qualitative research explores the factors that have influenced the use of urban green spaces (UGS) in Mexico City during the COVID-19 pandemic and the implications of their usage on residents’ well-being. This study was conducted using a combination of solicited audio and written diaries, photography, and in-depth interviews with 16 participants, aged 22 to 58. The article provides a critical reflection on the incentives and deterrents to the UGS use of participants while social distancing measures were in place. The results show that in Mexico City: (1) participants’ lack of access to UGS has hampered their use, mainly among those of low-income neighborhoods; (2) UGS size did not directly impact participants’ UGS use during the pandemic; and (3) women were deterred from accessing UGS due to safety concerns related to the fear of violence. Overall, the results suggest that UGS use has served as a coping mechanism to decrease the effects of stress and isolation caused by the pandemic, increasing users’ physical and mental well-being. This study’s conclusions can help develop future citizen participation tools that are useful for resilience in urban design, as they provide interesting insights into the perceptions of residents, such as the most valued characteristics of UGS.
The Study of Spatial Safety and Social Psychological Health Features of Deaf Children and Children with an Intellectual Disability in the Public School Environment Based on the Visual Access and Exposure (VAE) Model
Authors: Ma Ning , Ma Sa , Li Shuangjin , Ma Shuang , Pan Xinzhi , Sun Guohui
Published: April 2021

Nowadays, there is increasing attention towards the safety and feelings of children in urban or architectural space. In this study, the authors suggest a new approach based on the Visual Access and Exposure (VAE) Model to evaluate the spatial safety and social psychological health features of deaf children and children with an intellectual disability in the public school environment. The authors present a preliminary study of deaf children and children with an intellectual disability in a primary school located in Deyang by measuring the visual exposure and visual access in the public environment. The results illustrate that there are a few spaces, such as a long corridor and the space behind the elevators, that are not very safe for deaf children and children with an intellectual disability. In terms of social psychosocial preference, this special group prefers to stay in low visual access areas, which may be influenced by their introverted and impaired social communication ability. This study could have implications for the existence and optimization of an architecture design for relevant groups. With the increase in school bullying incidents and public psychological health problems related to youth, this approach could be used widely in the area of school safety and public psychological health management.
Prenatal Phthalates Exposure and Cord Thyroid Hormones: A Birth Cohort Study in Southern Taiwan
Authors: Huang Po-Chin , Kuo Pao-Lin , Chang Wei-Hsiang , Shih Shu-Fang , Chang Wan-Ting , Lee Ching-Chang
Published: April 2021

Background: The regulation of thyroid hormones in the early stages of gestation plays a crucial role in the outcome of a pregnancy. Furthermore, thyroid hormones are fundamental for the fetal development of all organs, including endocrine hormone changes in uterus. Endocrine disrupting chemicals have been shown to have an effect on thyroid hormone homeostasis in newborns, which affects their later development. Few studies have proposed how phthalates could alter thyroid function through several mechanisms and the possible effects on thyroid hormone homeostasis of phthalates on pregnant women. However, the effects of cord blood phthalates and prenatal phthalate exposure on thyroid hormones in newborns remain unclear. Objectives: We aim to follow up on our previous established subjects and determine the correlation between phthalate exposure and thyroid hormones in pregnant women and newborns. Materials and methods: We recruited 61 pregnant women from the Obstetrics and Gynecology Department of a medical hospital in southern Taiwan and followed up. High performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) was used to analyze urine samples for five phthalate metabolites. Serum levels of thyroid hormones were analyzed using electrochemoluminescence immunoassay (ECLIA) method. We used Spearman and Pearson correlation coefficients to evaluate the correlation between each phthalate metabolites in serum and the thyroid hormone levels in fetus and parturient. Finally, multiple logistic regression was used to explore the relationship between hormones and their corresponding phthalate metabolites in cord blood. Results: High MBP in cord blood was correlated with negative cord serum TSH in newborns (r = −0.25, p < 0.06). By using multiple linear regression after adjusting for potential confounders (gestational and maternal age), cord serum MBP levels showed a negative association with cord serum TSH (β = 0.217, p < 0.05), cord serum T4 (β = 1.71, p < 0.05) and cord serum T4 × TSH (β = 42.8, p < 0.05), respectively. Conclusion: We found that levels of cord serum TSH and T4 in newborns was significantly negatively associated with cord serum MBP levels after adjusting for significant covariate. The fall in TSH in newborns may potentially be delaying their development.
The Association between Preterm Birth and Ambient Air Pollution Exposure in Shiyan, China, 2015–2017
Authors: Chen Qihao , Ren Zhan , Liu Yujie , Qiu Yunfei , Yang Haomin , Zhou Yuren , Wang Xiaodie , Jiao Kuizhuang , Liao Jingling , Ma Lu
Published: April 2021

Shortening of the gestational duration has been found associated with ambient air pollution exposure. However, the critical exposure windows of ambient air pollution for gestational duration remain inconsistent, and the association between ambient air pollution and early term births (ETB, 37 to 38 weeks) has rarely been studied relative to preterm births (PTB, 28–37 weeks). A time-series study was conducted in Shiyan, a medium-sized city in China. Birth information was collected from the Shiyan Maternity and Child Health Hospital, and 13,111 pregnant women who gave birth between 2015 and 2017 were included. Data of the concentrations of air pollutants, including PM10, PM2.5, NO2, and SO2 and meteorological data, were collected in the corresponding gestational period. The Cox regression analysis was performed to estimate the relationship between ambient air pollution exposure and the risk of preterm birth after controlling the confounders, including maternal age, education, Gravidity, parity, fetal gender, and delivery mode. Very preterm birth (VPTB, 28–32 weeks) as a subtype of PTB was also incorporated in this study. The risk of VPTB and ETB was positively associated with maternal ambient air pollution exposure, and the correlation of gaseous pollutants was stronger than particulate matter. With respect to exposure windows, the critical trimester of air pollutants for different adverse pregnancy outcomes was different. The exposure windows of PM10, PM2.5, and SO2 for ETB were found in the third trimester, with HRs (hazard ratios) of 1.06 (95%CI: 1.04, 1.09), 1.07 (95%CI: 1.04, 1.11), and 1.28 (95%CI: 1.20, 1.35), respectively. However, for NO2, the second and third trimesters exhibited similar results, the HRs reaching 1.10 (95%CI: 1.03, 6.17) and 1.09 (95%CI: 1.03,1.15), respectively. This study extends and strengthen the evidence for a significant correlation between the ambient air pollution exposure during pregnancy and the risk of not only PTB but, also, ETB. Moreover, our findings suggest that the exposure windows during pregnancy vary with different air pollutants and pregnancy outcomes.
Role of Insulin Resistance in MAFLD
Authors: Sakurai Yoshitaka , Kubota Naoto , Yamauchi Toshimasa , Kadowaki Takashi
Published: April 2021

Many studies have reported that metabolic dysfunction is closely involved in the complex mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which has prompted a movement to consider renaming NAFLD as metabolic dysfunction-associated fatty liver disease (MAFLD). Metabolic dysfunction in this context encompasses obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and metabolic syndrome, with insulin resistance as the common underlying pathophysiology. Imbalance between energy intake and expenditure results in insulin resistance in various tissues and alteration of the gut microbiota, resulting in fat accumulation in the liver. The role of genetics has also been revealed in hepatic fat accumulation and fibrosis. In the process of fat accumulation in the liver, intracellular damage as well as hepatic insulin resistance further potentiates inflammation, fibrosis, and carcinogenesis. Increased lipogenic substrate supply from other tissues, hepatic zonation of Irs1, and other factors, including ER stress, play crucial roles in increased hepatic de novo lipogenesis in MAFLD with hepatic insulin resistance. Herein, we provide an overview of the factors contributing to and the role of systemic and local insulin resistance in the development and progression of MAFLD.
Viscoelastometric Testing to Assess Hemostasis of COVID-19: A Systematic Review
Authors: Bareille Marion , Hardy Michaël , Douxfils Jonathan , Roullet Stéphanie , Lasne Dominique , Levy Jerrold H. , Stépanian Alain , Susen Sophie , Frère Corinne , Lecompte Thomas , Mullier François
Published: April 2021

Infection by SARS-CoV-2 is associated with a high risk of thrombosis. The laboratory documentation of hypercoagulability and impaired fibrinolysis remains a challenge. Our aim was to assess the potential usefulness of viscoelastometric testing (VET) to predict thrombotic events in COVID-19 patients according to the literature. We also (i) analyzed the impact of anticoagulation and the methods used to neutralize heparin, (ii) analyzed whether maximal clot mechanical strength brings more information than Clauss fibrinogen, and (iii) critically scrutinized the diagnosis of hypofibrinolysis. We performed a systematic search in PubMed and Scopus databases until 31st December 2020. VET methods and parameters, and patients’ features and outcomes were extracted. VET was performed for 1063 patients (893 intensive care unit (ICU) and 170 non-ICU, 44 studies). There was extensive heterogeneity concerning study design, VET device used (ROTEM, TEG, Quantra and ClotPro) and reagents (with non-systematic use of heparin neutralization), timing of assay, and definition of hypercoagulable state. Notably, only 4 out of 25 studies using ROTEM reported data with heparinase (HEPTEM). The common findings were increased clot mechanical strength mainly due to excessive fibrinogen component and impaired to absent fibrinolysis, more conspicuous in the presence of an added plasminogen activator. Only 4 studies out of the 16 that addressed the point found an association of VETs with thrombotic events. So-called functional fibrinogen assessed by VETs showed a variable correlation with Clauss fibrinogen. Abnormal VET pattern, often evidenced despite standard prophylactic anticoagulation, tended to normalize after increased dosing. VET studies reported heterogeneity, and small sample sizes do not support an association between the poorly defined prothrombotic phenotype of COVID-19 and thrombotic events.
New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis
Authors: Bloem Annemieke , Bax Hannelore I. , Yusuf Erlangga , Verkaik Nelianne J.
Published: April 2021

Infective endocarditis, osteomyelitis, and osteosynthesis-associated infections are mostly caused by Gram-positive bacteria. They are often difficult to treat and are associated with a poor prognosis. In the past 20 years, nine antibiotic drugs with predominant activity against Gram-positive bacteria have been introduced and approved by the Food and Drug Administration or the European Medicines Agency: ceftaroline, daptomycin, telavancin, dalbavancin, oritavancin, linezolid, tedizolid, delafloxacin, and omadacycline. This narrative review aims to provide an overview on these antibiotics with a special focus on their use in infective endocarditis, osteomyelitis, and osteosynthesis-associated infections. Although some of these approved antibiotics are promising, they should not be used as first- or second-line therapy, awaiting more clinical data.
FDG-PET/CT and Para-Aortic Staging in Endometrial Cancer. A French Multicentric Study
Authors: Sallée Camille , Margueritte François , Gouy Sébastien , Tardieu Antoine , Belghiti Jérémie , Lambaudie Eric , Collinet Pierre , Guyon Frédéric , Legros Maxime , Monteil Jacques , Gauthier Tristan
Published: April 2021

Background: FDG-PET/CT is a noninvasive examination that could be helpful for the management of endometrial cancer. The aim of this study was to evaluate the performance of FDG-PET/CT in assessing para-aortic lymph-node involvement in high-risk endometrial cancer. Methods: We performed a retrospective multicenter study including all patients who had a high-risk endometrial cancer with a preoperative FDG-PET/CT and a para-aortic lymphadenectomy (PAL) between 2009 and 2019. The main objective was to evaluate the overall performance of FDG-PET/CT. The secondary objectives were to evaluate its performances according to the histological type and according to FDG-PET/CT date (before or after hysterectomy), and to compare its overall performance with that of the MRI scan. Results: We included 200 patients from six different centers. After the false positive FDG-PET/CT was reread by nuclear physicians, FDG-PET/CT had a sensitivity of 61.8%, a specificity of 89.7%, a positive predictive value of 69.4%, a negative predictive value of 86.1%, and an AUC of 0.76. There were no statistically significant differences in the performances according to either histological type and or FDG-PET/CT date. The sensitivity of FDG-PET/CT was better than that of MRI (p < 0.01), but the specificity was not (p = 0.82). Conclusion: Currently, FDG-PET/CT alone cannot replace PAL for the lymph node evaluation of high-risk endometrial cancers. It seems essential to reread it in multidisciplinary meetings before validating the therapeutic management of patients, particularly in the case of isolated para-aortic involvement.
A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis
Authors: Bec Cécilia , Rousset Axelle , Brandin Thibault , François Pauline , Rabarimeriarijaona Sitraka , Dumoulin Chloé , Heleu Gaëlle , Grimaud Fanny , Veran Julie , Magalon Guy , Dignat-George Françoise , Sabatier Florence , Louis Marie-Laure , Magalon Jérémy
Published: April 2021

(1) Background: The emergence of injectable “biologic” medication creates a new approach to treat osteoarthritis (OA). Among them, the use of intra-articular injection of PRP became widespread despite the absence of consensus regarding its optimal composition. The aim of this study was to retrospectively correlate an extensive biological characterization of injected PRP to the clinical responses of patients presenting knee OA. (2) Methods: This retrospective study included 75 patients with knee OA. Cartilage lesions were assessed using magnetic resonance imaging and the International Cartilage Regeneration Society (ICRS) classification. PRP extensive biological characterization was performed and patients’ subjective symptoms were recorded before injection and 3 and 6 months after injection using the Knee injury and Osteoarthritis Outcome Score (KOOS). Responders were defined by an improvement of 10 points on KOOS. (3) Results: At 6 months, 63.0% of the patients were responders. Impairment was characterized by a significantly higher proportion of patients with three compartments altered at baseline MRI and receiving a significantly higher dose of platelets compared to responders. (4) Conclusions: Single injection of pure PRP resulted in significant clinical improvement in the management of knee OA. Both baseline MRI and PRP biological features may be predictive factors of the clinical response, highlighting that a better understanding of action mechanism of PRP is still required.
Risk Factors for Mortality in Adult COVID-19 Patients Who Develop Bloodstream Infections Mostly Caused by Antimicrobial-Resistant Organisms: Analysis at a Large Teaching Hospital in Italy
Authors: Posteraro Brunella , De Angelis Giulia , Menchinelli Giulia , D’Inzeo Tiziana , Fiori Barbara , De Maio Flavio , Cortazzo Venere , Sanguinetti Maurizio , Spanu Teresa
Published: April 2021

The aim of this study was to characterize COVID-19 (SARS-CoV-2-infected) patients who develop bloodstream infection (BSI) and to assess risk factors associated with in-hospital mortality. We conducted a retrospective observational study of adult patients admitted for ≥48 h to a large Central Italy hospital for COVID-19 (1 March to 31 May 2020) who had or had not survived at discharge. We included only patients having blood cultures drawn or other inclusion criteria satisfied. Kaplan–Meier survival or Cox regression analyses were performed of 293 COVID-19 patients studied, 46 patients (15.7%) had a hospital-acquired clinically relevant BSI secondary to SARS-CoV-2 infection, accounting for 58 episodes (49 monomicrobial and 9 polymicrobial) in total. Twelve episodes (20.7%) occurred at day 3 of hospital admission. Sixty-nine species were isolated, including Staphylococcus aureus (32.8%), Enterobacterales (20.7%), Enterococcus faecalis (17.2%), Candida (13.8%) and Pseudomonas aeruginosa (10.3%). Of 69 isolates, 27 (39.1%) were multidrug-resistant organisms. Twelve (54.5%) of 22 patients for whom empirical antimicrobial therapy was inappropriate were infected by a multidrug-resistant organism. Of 46 patients, 26 (56.5%) survived and 20 (43.5%) died. Exploring variables for association with in-hospital mortality identified > 75-year age (HR 2.97, 95% CI 1.15–7.68, p = 0.02), septic shock (HR 6.55, 95% CI 2.36–18.23, p < 0.001) and BSI onset ≤ 3 days (HR 4.68, 95% CI 1.40–15.63, p = 0.01) as risk factors independently associated with death. In our hospital, mortality among COVID-19 patients with BSI was high. While continued vigilance against these infections is essential, identification of risk factors for mortality may help to reduce fatal outcomes in patients with COVID-19.
Does Ovarian Endometriosis Increase Oocyte Sensitivity to ICSI-Induced Mechanical Damage?
Authors: Scarafia Carlotta , Masciovecchio Martina , Canosa Stefano , Carosso Andrea Roberto , Gennarelli Gianluca , Revelli Alberto , Benedetto Chiara
Published: April 2021

Some studies have shown that ICSI obtains poorer results than conventional IVF in women with ovarian endometriosis, suggesting that oocytes could be sensitive to ICSI-induced mechanical damage. The aims of this study were to clarify (a) whether ovarian endometriosis could induce peculiar fragility in the oocyte, so that ICSI would finally result harmful, and (b) whether endometrioma removal before IVF could be advisable in order to avoid any hypothetical detrimental effect. We retrospectively studied 368 women, 203 with in situ endometrioma (128 of which underwent ICSI, 75 conventional IVF) and 164 who received laparoscopic stripping of endometrioma before ICSI. For women with in situ endometrioma, cIVF and ICSI outcome was comparable for all parameters studied, including the clinical pregnancy rate per embryo transfer (PR/ET: 31.8% vs. 39.5% in the cIVF and ICSI groups) and cumulative live birth rate per ovum pick-up (CLBR/OPU: 24.4% vs. 27.7%). ICSI outcome was similar comparing women with in situ endometrioma and women previously submitted to laparoscopic stripping of cysts (CLPR/OPU 27.7% vs. 25.3%). Our findings suggest that (a) in women with in situ endometrioma ICSI may be performed, when needed, without harming oocytes and compromising the outcome and (b) that there is no advantage in removing endometrioma before ICSI.
Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics
Authors: Flahault Adrien , Altit Gabriel , Sonea Aurélie , Gervais Anne-Sophie , Mian Muhammad Oneeb Rehman , Wu Rong , Desbrousses Eva , Mai Ly , Cloutier Anik , Simoneau Jessica , Lapointe Anie , Villeneuve Andréanne , Garceau Patrick , White Michel , Bigras Jean-Luc , Luu Thuy Mai , Nuyt Anne Monique
Published: April 2021

Preterm birth increases risk of cardiovascular disease and early death. A body of evidence suggests left ventricle (LV) echocardiographic alterations in children and adults born preterm. We aimed to determine if neonatal characteristics were associated with alterations in LV structure and function in preterm adults. We evaluated a cohort of 86 young adults born preterm below 30 weeks of gestation, and 85 full-term controls. We determined LV dimensions and function using tissue Doppler imaging, conventional and speckle tracking echocardiography (STE). Adults born preterm had smaller LV dimensions, but these differences did not remain after adjustment for body surface area (BSA), which was smaller in the preterm group. Stroke volume and cardiac output were reduced even after adjustment for BSA. We found a smaller e’ wave in the preterm group, but other markers of systolic and diastolic function did not differ. Use of antenatal steroids may be associated with a further reduced cardiac output in those born preterm. Adults born preterm show alterations in markers of LV dimensions and function. Identification of these markers may represent opportunities for early prevention of cardiovascular events in this at-risk population.
Thrombotic Complications in Patients with Immune-Mediated Hemolysis
Authors: Capecchi Marco , Ciavarella Alessandro , Artoni Andrea , Abbattista Maria , Martinelli Ida
Published: April 2021

Autoimmune hemolytic anemias are rare and heterogeneous disorders characterized by hemolysis, which is a well-recognized risk factor for thrombosis. The most common immune-mediated anemias are represented by autoimmune hemolytic anemia and paroxysmal nocturnal hemoglobinuria, both associated with a high rate of thrombosis. Multiple pathophysiological mechanisms for thrombosis have been proposed, involving hemolysis itself and additional effects of the immune system. Despite the increasing awareness of the thrombotic risk in these conditions, evidence-based guidance on prevention and management of thrombotic events is lacking. We herein report available evidence on epidemiological data on thrombosis and thrombophilia in immune-mediated hemolysis, together with possible underlying pathophysiological mechanisms. In addition, we summarize current recommendations for treatment of thrombosis in immune-mediated hemolysis. In particular, we address the issue of thrombotic complications treatment and prophylaxis by proposing a therapeutic algorithm, focusing on specific situations such as splenectomy and pregnancy.
The Use of a Light-Emitting Diode Device for Neck Rejuvenation and Its Safety on Thyroid Glands
Authors: Lee Young In , Lee Eunjung , Nam Kee-Hyun , Shin Dong Yeob , Kim Jihee , Suk Jangmi , Kwak Jin Young , Lee Ju Hee
Published: April 2021

Home-use light-emitting diodes (LEDs) are attracting growing attention regarding their anti-aging effects. Although most previous studies on the use of LED devices as a form of low-level laser therapy reported no significant adverse events, questions regarding the safety of using a light source on secretory tissues have been raised. This study aimed to assess the safety and efficacy of a home-use LED device for neck skin rejuvenation, particularly regarding its effect on thyroid gland morphology and function. Thyroid function tests and ultrasonographic analyses showed no significant changes after 16 weeks of LED use. Evaluation using the Lemperle wrinkle scale and global improvement scales by both investigators and subjects showed significant improvement after 16 weeks of daily application, as well as 8 weeks after discontinuation. Biophysical parameters, such as hydration, elasticity, and density, also showed significant improvements. Hence, the long-term use of the LED device was safe and effective for neck rejuvenation, and showed no significant side effects on the adjacent thyroid and parathyroid glands.
Bone Metastases from Gastric Cancer: What We Know and How to Deal with Them
Authors: Petrillo Angelica , Giunta Emilio Francesco , Pappalardo Annalisa , Bosso Davide , Attademo Laura , Cardalesi Cinzia , Diana Anna , Fabbrocini Antonietta , Fabozzi Teresa , Giordano Pasqualina , Ottaviano Margaret , Rosanova Mario , Silvestri Antonia , Federico Piera , Daniele Bruno
Published: April 2021

Gastric cancer (GC) is the third cause of cancer-related death worldwide; the prognosis is poor especially in the case of metastatic disease. Liver, lymph nodes, peritoneum, and lung are the most frequent sites of metastases from GC; however, bone metastases from GC have been reported in the literature. Nevertheless, it is unclear how the metastatic sites may affect the prognosis. In particular, knowledge about the impact of bone metastases on GC patients’ outcome is scant, and this may be related to the rarity of bone lesions and/or their underestimation at the time of diagnosis. In fact, there is still a lack of specific recommendation for their detection at the diagnosis. Then, the majority of the evidences in this field came from retrospective analysis on very heterogeneous study populations. In this context, the aim of this narrative review is to delineate an overview about the evidences existing about bone metastases in GC patients, focusing on their incidence and biology, the prognostic role of bone involvement, and their possible implication in the treatment choice.
Research Progress in Transfer, Accumulation and Effects of Microplastics in the Oceans
Authors: Arienzo Michele , Ferrara Luciano , Trifuoggi Marco
Published: April 2021

One of the major concerns regarding the presence of plastics in ocean environments are the effects on marine biota. Plastics can be distinguished in macro- (≥25 mm), meso- (<25 mm–5 mm) micro- (<5 mm–1 µm), and nano-plastic (<1 µm) and are practically omnipresent in aquatic habitats and subject to long-range transport. The purpose of this review is to report the last findings on the release, transfer, accumulation, and effects of micro-plastics, MPs, in the oceans. MPs have the chance to adsorb different kind of organisms and compounds on their outer surface, including bacteria, viruses, algae, and abiotic substances. In this way, they can cause sever hazard once they enter the food chain. Their harm to higher organisms is discussed as well as main routes of MPs–organism interactions, i.e., ventilation, and ingestion. Potential effects on populations, communities, and ecosystems and uptake routes and transition into tissues are discussed. In consideration of the potential threats of plastic particles to ecological functions and human health risks, we recommend specific directions of future research approaches.
Near-Inertial Waves Induced by Typhoon Megi (2010) in the South China Sea
Authors: Cao Anzhou , Guo Zheng , Pan Yunhe , Song Jinbao , He Hailun , Li Peiliang
Published: April 2021

Near-inertial waves (NIWs) are a kind of internal wave, which are usually generated by synoptic wind forcing and play an important role in the oceanic energy budget. However, the lack of in situ observations limits our understanding of NIWs to some extent. Through a comparison with in situ observations, in this study, we first showed that the hybrid coordinate ocean model reanalysis results could reasonably reproduce the typhoon-induced NIWs, and we then adopted these data to investigate the NIWs induced by typhoon Megi in 2010 in the South China Sea (SCS). The results indicate that Megi-induced near-inertial kinetic energy was mainly concentrated in the SCS Basin. In the vertical direction, Megi-induced NIWs could propagate to 1000 m depth. The damping and modal content of Megi-induced NIWs were site-dependent: In the region near Megi’s track, NIWs were dominated by the first three baroclinic modes and damped quickly; whereas in two zones to the west of the Luzon Island and Luzon Strait, the e-folding time of Megi-induced NIWs could be longer than 20 days and higher modes (mode-4 to mode-7) were enhanced several days after the passage of Megi. Possible mechanisms of these phenomena were also explored in this study.
The Benefits of Combining Global and Local Data—A Showcase for Valuation and Mapping of Mangrove Climate Regulation and Food Provisioning Services within a Protected Area in Pará, North Brazil
Authors: Gutting Robin , Syrbe Ralf-Uwe , Grunewald Karsten , Mehlig Ulf , Helfer Véronique , Zimmer Martin
Published: April 2021

Mangrove forests provide a large variety of ecosystem services (ES) to coastal societies. Using a case study focusing on the Ajuruteua peninsula in Northern Brazil and two ES, food provisioning (ES1) and global climate regulation (ES2), this paper proposes a new framework for quantifying and valuing mangrove ES and allow for their small-scale mapping. We modelled and spatialised the two ES from different perspectives, the demand (ES1) and the supply (ES2) side respectively. This was performed by combining worldwide databases related to the global human population (ES1) or mangrove distribution and canopy height (ES2) with locally derived parameters, such as crab catches (ES1) or species-specific allometric equations based on local estimates of tree structural parameters (ES2). Based on this approach, we could estimate that the area delivers the basic nutrition of about 1400 households, which equals 2.7 million USD, and that the mangrove biomass in the area contains 2.1 million Mg C, amounting to 50.9 million USD, if it were paid as certificates. In addition to those figures, we provide high-resolution maps showing which areas are more valuable for the two respective ES, information that could help inform management strategies in the future.
Influence of Land Use on Avian Diversity in North African Urban Environments
Authors: Aouissi Hani Amir , Petrişor Alexandru-Ionuţ , Ababsa Mostefa , Boştenaru-Dan Maria , Tourki Mahmoud , Bouslama Zihad
Published: April 2021

Land cover and use changes are important to study for their impact on ecosystem services and ultimately on sustainability. In urban environments, a particularly important research question addresses the relationship between urbanization-related changes and biodiversity, subject to controversies in the literature. Birds are an important ecological group, and useful for answering this question. The present study builds upon the hypothesis according to which avian diversity decreases with urbanization. In order to answer it, a sample of 4245 observations from 650 sites in Annaba, Algeria, obtained through the point abundance index method, were investigated by computing Shannon-Wiener’s diversity index and the species richness, mapping them, and analyzing the results statistically. The findings confirm the study hypothesis and are relevant for planning, as they stress the role of urban green spaces as biodiversity hotspots, and plead for the need of connecting them. From a planning perspective, the results emphasize the need for interconnecting the green infrastructure through avian corridors. Moreover, the results fill in an important lack of data on the biodiversity of the region, and are relevant for other similar Mediterranean areas. Future studies could use the findings to compare with data from other countries and continents.
The Impact of Lifetime Alcohol and Cigarette Smoking Loads on Amyotrophic Lateral Sclerosis Progression: A Cross-Sectional Study
Authors: Cucovici Aliona , Fontana Andrea , Ivashynka Andrei , Russo Sergio , Renna Valentina , Mazzini Letizia , Gagliardi Ileana , Mandrioli Jessica , Martinelli Ilaria , Lisnic Vitalie , Muresanu Dafin Fior , Zarrelli Michele , Copetti Massimiliano , Leone Maurizio A.
Published: April 2021

Background—Amyotrophic lateral sclerosis (ALS) is a devastating and untreatable motor neuron disease; smoking and alcohol drinking may impact its progression rate. Objective—To ascertain the influence of smoking and alcohol consumption on ALS progression rates. Methods—Cross-sectional multicenter study, including 241 consecutive patients (145 males); mean age at onset was 59.9 ± 11.8 years. Cigarette smoking and alcohol consumption data were collected at recruitment through a validated questionnaire. Patients were categorized into three groups according to ΔFS (derived from the ALS Functional Rating Scale-Revised and disease duration from onset): slow (n = 81), intermediate (80), and fast progressors (80). Results—Current smokers accounted for 44 (18.3%) of the participants, former smokers accounted for 10 (4.1%), and non-smokers accounted for 187 (77.6%). The age of ALS onset was lower in current smokers than non-smokers, and the ΔFS was slightly, although not significantly, higher for smokers of >14 cigarettes/day. Current alcohol drinkers accounted for 147 (61.0%) of the participants, former drinkers accounted for 5 (2.1%), and non-drinkers accounted for 89 (36.9%). The log(ΔFS) was weakly correlated only with the duration of alcohol consumption (p = 0.028), but not with the mean number of drinks/day or the drink-years. Conclusions: This cross-sectional multicenter study suggested a possible minor role for smoking in worsening disease progression. A possible interaction with alcohol drinking was suggested.
The Use of Upconversion Nanoparticles in Prostate Cancer Photodynamic Therapy
Authors: Osuchowski Michał , Osuchowski Filip , Latos Wojciech , Kawczyk-Krupka Aleksandra
Published: April 2021

Photodynamic Therapy (PDT) is a cancer treatment that uses light, a photosensitizer, and oxygen to destroy tumors. This article is a review of approaches to the treatment of prostate cancer applying upconversion nanoparticles (UCNPs). UCNPs have become a phenomenon that are rapidly gaining recognition in medicine. They have proven to be highly selective and specific and present a powerful tool in the diagnosis and treatment of prostate cancer. Prostate cancer is a huge health problem in Western countries. Its early detection can significantly improve patients’ prognosis, but currently used diagnostic methods leave much to be desired. Recently developed methodologies regarding UCNP research between the years 2021 and 2014 for prostate cancer PDT will also be discussed. Current limitations in PDT include tissue irradiation with visible wavelengths that have a short tissue penetration depth. PDT with the objectives to synthesize UCNPs composed of a lanthanide core with a coating of adsorbed dye that will generate fluorescence after excitation with near-infrared light to illuminate deep tissue is a subject of intense research in prostate cancer.