bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective Effect of Co Q10 and Candesartan on Bleomyycin Induced Lung Fibrosis in Rats
Authors: Fatima Mohammad Saeed Mahdi  , Mustafa Ghazi Alabbassi  , Muthanna Ibrahim Al-Ezzi
Published: April 2022

Fibrosis of the lungs is the final phase of many lung illnesses. Its characterized by excessive matrix production leading to the normal lung architecture destruction and eventually death. CoQ10 is an essential constituent of membrane oxidoreductase System. It is an intracellularly localized antioxidant

 

enzyme that is endogenously synthesized in humans. CoQ10 protects cellular components from destruction by free radical-induced oxidative damage. candesartan is a selective antagonist of angiotensin II type 1 receptor (AT1) and is widely employed for treatment of hypertension. Most up to date research shows angiotensin II close involvement with damage and fibrosis process in tissues of organs of circulation.

Objective: This animal study was designed to investigate the effect of Co Q10 and candesartan as antifibrotic agents against pulmonary fibrosis focusing on selected markers involved in pulmonary fibrosis.

Materials and Method: 48 rats divided randomly into four groups, each consisting of 12 male rats. Group I: (Control group), the rats in this group received single injection of 0.2 ml normal saline via intratracheal route. Group II: (The BLM group), received BLM (8.3 U/kg) as a single dose via the intratracheal rout. Group III: (BLM+CoQ10 group) rats receive BLM (8.3 U/kg) as sulfate salt dissolved in 0.1 ml of normal saline via the intratracheal instillation concomitant with 100 mg/kg co Q 10 per day orally for 5 days before and 10 days after BLM injection. Group IV: (BLM+ candesartan group) rats receive BLM (8.3 U/kg) as sulfate salt dissolved in 0.1 ml of normal saline via the intratracheal instillation concomitant with (10 mg/kg) candesartan per day orally for 5 days before and 10 days after BLM injection. The studied serum biomarkers were glutathione, arachidonate 5 lipoxygenase in addition to histopathological examination using trichrome stain.

 Results: serum GSH concentration was lower in BLM group in comparison with the control group and the (BLM+ CoQ10) but this difference is not statistically significant. The serum GSH levels showed a significant(P<0.05) elevation in (BLM+ Candesartan) group when compared with the levels in the BLM group. The serum ALOX5 concentration was significantly elevated in BLM group in comparison with the control group (P < 0.05). The serum ALOX5 levels were highly significantly lower in (BLM +CoQ10) (P < 0.01) and very highly significantly lower in the (BLM+ Candesartan) group (P < 0.001) when comparing it with the levels in the BLM group. furthermore, histologically CoQ10 and candesartan showed reduction in the numbers of inflammation cells and a decrease in the damage to the lung architecture and fibrosis induced by bleomycin.

Conclusion: CoQ10 and candesartan decrease pulmonary fibrosis induced by bleomycin in male rats.
Detection of Human Herpes Virus-6 in saliva of Patients with Bell's palsy
Authors: Mustafa Hameed Majeed  , Abdul–Kareem Kadhim Alkhazraji
Published: April 2022

Background: Bell’s palsy is unilateral peripheral paralysis of the seventh cranial nerve, several mechanisms have been proposed in the pathogenesis of this disease, among the viral infections specially herpes virus's family including roseola viruses that have been detected in patients' saliva.

Method: A case-control study conducted on Bell’s palsy patients at al-Imamein Al-kadhimein Medical City throughout the period from March 2019 to November 2019. Saliva samples were taken from 50 patients (18-55) years of age with early stages of Bell's palsy and from 50 apparently healthy and age and sex matched volunteers as control. Viral DNA was extracted from the saliva and then real time PCR for detection and quantification of HHV6 DNA in these patients

Results: Saliva samples taken from 28 patients in the Bell’s palsy patients (56%) tested positive for HHV6, as vs. to just 8 (16%) in the healthy group(control) (P= 0.028). There was increase amount of HHV6 load in patients compare to control group (p=0.001). Regarding the demographic values, an important difference in the detection rate for Human herpes virus-6 between male (64%) and females (35%) (P= 0.02). There was significant correlation between age and grading (p =0.01), as increase age correlate with high grading, also between viral load of HH6 and grading as increase viral load of the virus correlate with high grading (p = 0.001).

Conclusion: HHV-6 virus might have a potential role in the pathogenesis of Bell’s palsy.
Preparation and evaluation of oral capsules containing apigenin nanocrystals prepared by ultrasonication
Authors: Mahmood A. Haiss  , Nidhal K. Maraie
Published: April 2022

This work aims to enhance dissolution rate, increase absorption and bioavailability of Apigenin by formulating it as nanocrystal suspension employing ultrasonic technology. Two different diluents; (5%, 10%) microcrystalline cellulose (MCC) and (2%, 3%) anhydrous lactose were used to prepare hard gelatin

capsules for two optimum types for apigenin nanocrystals prepared in our laboratory utilizing ultrasonication technique using 1% tween 80 (F6) and 2% poloxamer 188 (F20). The results showed that the marketed capsules (containing MCC) had about half the dissolution rate than all the prepared nanocrystals capsules formulas, and the nanocrystals prepared with poloxamer gave 90% release within 20 minutes and 100% release with 2 hours with excellent flow properties with no effect of the added diluents while the addition of diluents improved significantly the release of nanocrystals capsules (F6) with 1% tween 80 with good flow properties. The results suggested that utilizing apigenin nanocrystals prepared by ultrasonication technique may improve drug absorption and bioavailability with a reduced required dose.
Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin.
Authors: Yasir F. Muhsin  , Shakir M. Alwan  , Ayad Kareem Khan
Published: April 2022

Infections caused by bacteria have a significant impact on public health. Chemical synthesis of new derivatives of cephalexin inked to amino acid (tryptophan or histidine) through an amide bond at the acyl side chain is achieved. This is a new

approach of incorporating, tryptophan and histidine into the the primary amino group of cephalexin, in order to provide a bulky group very close to the β-lactam ring. This chemical addition act as isosteric group to the alkoximino that protect beta lactam ring from bacterial beta lactamase enzyme. The new derivatives may show resistance to β-lactamases, improve activity and pharmacokinetic properties and may give new life for old drugs that are susceptible to hydrolysis by most β-lactamases. The chemical structures of these derivatives were confirmed by: FTIR, 1H-NMR spectroscopy, elemental micro analysis and some physical properties. Molecular docking on serine beta lactamase and prediction of ADME parameters were recorded using GOLD suite and Swiss ADME software respectively. Docking scores of the new derivatives of Cephalexin on β-lactamases were higher than those of Cephalexin, which may indicate better activity
Development and validation of bioanalytical method for the determination of valsartan in human plasma
Authors: Samir Hasson Aziz Ramadhan
Published: April 2022

A bioanalytical method which utilizes high performance liquid chromatography with mass spectrometry method has been developed and validated for the quantification of valsartan in human plasma. The samples were processed by precipitation with formic acid then extracted with diethyl ether. Benazepril

 

was used as an internal standard. The chromatographic separation is performed through C18 column with a mobile phase consisting of deionized water, acetonitrile and formic acid, followed by mass spectrometric detection in the positive ionization mode. The proposed method was specific and had been validated in the linear range of 50.0 – 5000.0 ng/ml for valsartan. The validation results were as follows: the intra-day and inter-day precision were 3.46 to 8.33% and 5.85 to 7.05% respectively, the intra-day and inter-day accuracy were 93.53 to 107.13% and 95.26 to 104.0% respectively. The recovery for valsartan and benazepril was 81.4% and 113.7% respectively. Also, stability was studied and the results obtained for short-term stability 99.24 to 102.32%, for freeze / thaw stability 99.75 to 99.95% and for long-term stability 98.24 to 103.03%. It can be concluded that the method can be applied in pharmacokinetic bioequivalence studies.
Recuento histórico de aspectos de formación y profesionalización de las artes plásticas en Chihuahua
Authors: Montelongo Silva Elizabeth , Trujillo Holguín Jesús Adolfo
Published: April 2022

En la ciudad de Chihuahua la inclusión de las artes al sistema educativo corresponde al periodo posterior a la guerra de Independencia hacia el año 1838, cuando se sumaron al plan de estudios de las escuelas de nivel básico las materias de dibujo y pintura, asentándose de esta manera curricularmente las artes plásticas. Fue así como la fundación de escuelas especializadas en la formación profesional artística revalorizó el concepto de creación artística, dignificando su quehacer y equiparándolo con cualquier otra profesión. En este trabajo se presenta un avance de la investigación en curso que pretende profundizar en los antecedentes históricos de formación artística que influyen en la producción local. Se desarrolló a partir de un análisis documental de fuentes consultadas en el Archivo Histórico de la Universidad Autónoma de Chihuahua (UACH), así como con entrevistas realizadas a diez profesionales de las artes, egresados y docentes de la Facultad de Artes, obteniendo como conclusiones preliminares que la formación profesional influye en aspectos técnicos y teóricos, y el contexto histórico, social y cultural local sobre la parte creativa, haciendo a su vez distinciones de edad y género en cuanto a perspectiva de proyección artística.
Respuesta artística e iconográfica del muralismo urbano chihuahuense ante la contingencia por COVID-19
Authors: Liddiard Cárdenas Adán Erubiel , Hernández Orozco Guillermo
Published: April 2022

El presente trabajo documenta y analiza dos murales creados en la ciudad de Chihuahua a finales del año 2020, los cuales presentan una respuesta artística a la actual contingencia sanitaria por COVID-19. Se da una aportación al análisis iconográfico de representaciones emergentes similares, descubriendo creativas formas de representar al personal de salud chihuahuense, todo dentro del reconocimiento social. El contexto sanitario actual se aborda, mientras los resultados de la interpretación iconográfica refieren un acercamiento al campo de estudio: la expresión artística en la cultura urbana chihuahuense. La cualidad educativa y social intrínseca en la actividad muralista se observa en las obras presentadas, las cuales reflejan por medio de la metáfora visual y el simbolismo el agradecimiento al trabajo del personal de salud.
La mujer ralámuri y su participación educativa en técnicas artesanales dentro del municipio de Bocoyna, Chihuahua
Authors: Anchondo Aguilar Addy , Porras Flores Damián Aarón , González Aldana Ricardo Aarón
Published: April 2022

Las técnicas generacionales juegan un papel significativo en la sucesión, fortalecimiento de los conocimientos ancestrales dentro del municipio de Bocoyna. Esta investigación tiene como objetivo presentar un análisis de la mujer ralámuri en la transmisión de técnicas y conocimientos tradicionales para producir y elaborar artesanías. Utiliza los enfoques cualitativo y cuantitativo, fundamentada en la teoría analítico-descriptiva, a través de las técnicas de encuestas, observación de campo y entrevistas a mujeres rarámuri en diferentes localidades, dando como resultado el hallazgo de una dualidad en la responsabilidad para educar a los hijos en los deberes y técnicas generacionales, sin embargo, la mujer rarámuri tiene mayor responsabilidad ya que pasa más tiempo con los hijos; tiene mayor participación en la educación tradicional, comenzando la formación a los 12 o 13 años, con una duración entre cuatro y seis meses, practicando dos a tres horas diarias, además, de preservación de sus tradiciones y costumbres dentro de su comunidad.
PENGARUH PAJAK BUMI DAN BANGUNAN DAN DANA OTONOMI KHUSUS TERHADAP BELANJA MODAL JARINGAN Bukti Empiris dari Aceh
Authors: Syukriy Abdullah  , Endra Gunawan  , Syukur Selamat Karo-Karo
Published: April 2022

Tujuan penelitian ini adalah memberikan bukti empiris tentang pengaruh dana otonomi khusus (Otsus) dan pajak bumi dan bangunan (PBB) terhadap belanja modal jaringan (BMJ) pada pemerintah daerah di Aceh selama tahun 2015-2018 dengan menggunakan model regresi linier berganda. Data yang digunakan adalah data sekunder yang bersumber dari laporan keuangan pemerintah daerah kabupaten dan kota yang telah diaudit oleh auditor eksternal. Hasil penelitian menunjukkan bahwa Dana Otsus berpengaruh positif terhadap BMJ, sedangkan PBB tidak berpengaruh. Hasil ini membuktikan bahwa pemerintah daerah di Aceh tidak mengalokasikan pendapatan PBB untuk menyediakan infrastruktur yang bermanfaat bagi pembayar PBB, sementara Dana Otsus menentukan besaran realisasi BMJ pada kabupaten/kota di Aceh.
DAMPAK COVID-19 PADA PASAR SAHAM SYARIAH DI INDONESIA
Authors: Shelly Midesia
Published: April 2022

Pandemi COVID-19 membawa dampak terhadap penurunan ekonomi secara global dalam semua jenis usaha perekonomian, termasuk pasar modal. Salah satu dampak COVID-19 yaitu mampu menurunkan harga saham IHSG pada umumnya dan pada semua sektor pasar modal pada khususnya. Dalam masa pengamatan selama Maret 2020, reaksi awal emiten saham syariah pada tanggal 17 Maret 2020 yaitu harga saham serentak menurun di semua sektor bursa efek. Sektor consumer goods industry merupakan sektor yang terbaik dalam menghadapi pandemi COVID-19 hal ini juga didukung dengan jenis bidang usaha tiap emiten yang ada pada sektor ini. Saham sektor mining mampu menjaga kinerja sahamnya, sehingga kepanikan terhadap COVID-19 yang membuat harga saham rendah pada pertengahan Maret hanya terjadi sebentar dan emiten sektor ini dapat dengan mudah menaikkan kembali harga sahamnya. Sedangkan sektor basic industry and chemical, sektor infrastructure, utilities, and transportation, dan sektor miscellaneous industry membutuhkan waktu lebih dari dua minggu untuk bisa kembali menaikkan harga sahamnya
PENGARUH STRUKTUR AKTIVA, LIKUIDITAS, UKURAN PERUSAHAAN DAN PROFITABILITAS TERHADAP STRUKTUR MODAL PERUSAHAAN INDUSTRI DASAR DAN KIMIA DI BEI
Authors: Nur Qosidah  , Kartika Hendra Titisari  , Anita Wijaya
Published: April 2022

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan pengaruh struktur aset, likuiditas, ukuran perusahaan dan profitabilitas terhadap struktur modal pada perusahaan industri dasar dan kimia di BEI. Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif. Populasinya adalah seluruh Perusahaan Industri Dasar dan Kimia di BEI periode 2014-2018. Sampel adalah laporan keuangan Perusahaan Industri Dasar dan Kimia di BEI periode 2014-2018. Metode pengambilan sampel menggunakan purposive sampling. Teknik analisis data yang digunakan adalah analisis statistik. Hal ini mengakibatkan struktur aset berpengaruh tidak signifikan terhadap struktur modal. Likuiditas berpengaruh signifikan terhadap struktur modal. Ukuran perusahaan berpengaruh tidak signifikan terhadap struktur modal. Profitabilitas berpengaruh tidak signifikan terhadap struktur modal. Hasil penentuan koefisien menunjukkan struktur aset, likuiditas, ukuran perusahaan dan profitabilitas memiliki pengaruh sebesar 37,7% terhadap struktur modal
PENGARUH SUMBER DAYA MANUSIA DAN KOMITMEN ORGANISASI TERHADAP PENERAPAN STANDAR AKUNTANSI PEMERINTAH BERBASIS AKRUAL (Studi Pada Badan Pengelolaan Keuangan Kota Banda Aceh)
Authors: Mislinawati  , Dini Attar  , Muhammad Ikhsan
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh sumber daya manusia dan komitmen organisasi terhadap penerapan standar akuntansi pemerintah berbasis akrual di Badan Pengelolaan Keuangan Kota Banda Aceh. Penelitian ini dilakukan dengan menggunakan metode kuantitatif. Populasi dalam penelitian ini seluruh pegawai Badan Pengelolaan keuangan Kota Banda Aceh. Jenis penentuan sampel adalah dengan cara purposive sampling. Data dikumpulkan dengan menyebarkan langsung kuesioner kepada responden. Teknik analisis data yang digunakan adalah regresi linier berganda dengan bantuan aplikasi Statistical Package For Social Science (SPSS) 25. Kesimpulan dari penelitian ini adalah variabel sumber daya manusia tidak berpengaruh dan tidak signifikan terhadap penerapan standar akuntansi pemerintah berbasis akrual. variabel komitmen organisasi berpengaruh dan signifikan terhadap penerapan standar akuntansi pemerintah berbasis akrual sedangkan secara simultan kedua variabel berpengaruh dan signifikan terhadap penerapan standar akuntansi pemerintah berbasis akrual.
PERAN KETERIKATAN DOSEN DALAM MENINGKATKAN KINERJA PERGURUAN TINGGI SWASTA ACEH SELAMA COVID-19
Authors: Muhammad Zainal Abidin  , Lubis Abdul Rahman , Muslim A. Djalil  , Nurdasila Darsono
Published: April 2022

Peneliti menginvestigasi hubungan employee engagement, meeting application, leadership dan organization performance. Riset ini mengkombinasikan model social media usage yang telah dikembangkan sebelumnya dengan engagement model oleh William Khan. Riset ini menggunakan metode kuantitatif dengan populasi lembaga perguruan tinggi swasta di Propinsi Aceh dan jumlah sampel 280 orang dosen yang diambil dengan teknik purposive sampling berdasarkan pada kriteria tertentu. Hasil analisis model persamaan struktural menunjukan bahwa kinerja perguruan tinggi swasta di aceh dapat dipengaruhi oleh employee engagement, meeting application,  dan leadership.
Analisis Penilaian Skor Pengungkapan Islamic Social Reporting (ISR) pada PerusahaanYang Terdaftar di Jakarta Islamic Index (JII)
Authors: Meutia Handayani  , Emilda Kadriani  , Icha Ayuningsih  , Talbani Farlian
Published: April 2022

Penelitian ini bertujuan untuk menganalisis penilaian skor pengungkapan ISR (Islamic Sosial Reporting) pada perusahaan yang terdaftar di Jakarta Islamic Index (JII). Data yang digunakan adalah laporan tahunan perusahaan yang terdaftar pada JII yang mengungkapkan Islamic social repoertingnya. Pengungkapan Islamic social Rrepoerting diperlukan sebagai bentuk tanggung jawab perusahaan yang kegiatannya tidak bertentangan dengan syariat islam kepada lingkungan social disekitarnya. data yang dilakukan dalam penelitian ini adalah dengan menggunakan metode data sekunder dan di lakukan analisis deskriptif terhadap hasil penelitian. Hasil  dari penelitian ini menunjukkan bahwa indeks ISR tertinggi dimiliki oleh PT. Aneka Tambang (Persero) Tbk dan PT. Indofood Sukses Makmur Tbk. Skor ISR terendah dimiliki oleh PT. Ciputra Developmen dan Summarecon Agung Tbk
ANALISIS LIKUIDITAS, PROFITABILITAS DAN SOLVABILITAS TERHADAP HARGA SAHAM PERUSAHAAN PERBANKAN TERINDEKS LQ45
Authors: Dewi Maya Sari  , Mutia Arfiani  , Popi Amanda
Published: April 2022

Penelitian ini bertujuan untuk menjelaskan hubungan antara likuiditas, profitabilitas dan solvabilitas terhadap harga saham. Pengamatan dilakukan pada perusahaan perbankan terindeks LQ45 periode 2017 sampai dengan 2019. Metode pengumpulan data dilakukan denegan cara purposive sampling dan dianalisis dengan metode deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa perubahan likuiditas, profitabilitas, dan solvabilitas dapat menjelaskan perubahan yang terjadi pada harga saham perusahaan perbankan terindeks LQ45 selama periode 2017 sampai dengan 2019.
Модернизация процесса обслуживания пользователей университетских библиотек
Authors: Барышев Р. А. , Цветочкина И. А. , Касянчук Е. Н. , Бабина О. И.
Published: April 2022

Актуальность данной темы обусловлена цифровизацией всех отраслей хозяйства и социальной сферы, что ставит перед обществом новые задачи. Библиотеки вузов перестраивают свою работу и переводят основные направления библиотечной деятельности в дистанционный формат. С переходом на удалённую работу в период сложной эпидемиологической обстановки, связанной с пандемией COVID-19, библиотеки акцентировали своё внимание на дистанционном обслуживании пользователей. В связи с полным переходом на дистанционный формат обслуживания перед библиотекой встала проблема модернизации бизнес-процессов. В статье представлен опыт Научной библиотеки Сибирского федерального университета; рассмотрен процесс обслуживания пользователей университетской библиотеки в новом формате. Анализируется система ИРИ и ДОР на новом уровне. Представлена проактивная модель библиотеки, под которой понимается процесс информационного обслуживания читателей в любой форме и на любом носителе на основе классических и сетевых форм обслуживания на базе сервисов опережения запроса. Представленные в статье материалы позволяют сотрудникам и пользователям библиотеки по-новому выстроить взаимодействие между библиотекарем и читателем, расширить возможности библиотеки. Предложенная авторами технология позволяет на основе сервисов опережения запросов читателей выходить за рамки их потребностей и создавать зону ближайшего развития интересов. Статья представляет собой авторское осмысление происходящей цифровой трансформации деятельности вузовских библиотек.
Pengaruh Latihan Kekuatan Otot Lengan Terhadap Kemampuan Tembakan Hukuman (Free Throw) dalam Bola Basket Putra Club Basket Tunas Rejang Lebong
Authors: Alnova Joese , Syafrial Syafrial , Defliyanto Defliyanto
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh Latihan Kekuatan Otot Lengan Terhadap Kemapuan Tembakan Hukuman (Free Throw) Dalam Bola Basket. Penelitian ini menggunakan metode eksperimen, design yang digunakan adalah design one group pretest – posttest Populasi dalam penelitian ini berjumlah 25 orang atlet, pemilihan sampel mengunakan total sampling dimana seluruh populasi diambil sebagai sampel penelitian. Teknik pengumpulan data dalam penelitian ini dengan metode tes secara langsung yaitu menggunakan tes (Free Throw) dalam permainan bola basket. Uji persyarat statistik memenuhi syarat homogen dan data berdistribusi normal berdasarkan hitungan statistik didapat hasil dari data t hitung = 7.027 > t tabel = 2.064 dengan taraf  = 0,05. Hasil penelitian ini menunjukkan terdapat pengaruh antara Latihan kekuatan otot lengan terhadap kemampuan Tembakan Hukuman (Free Throw) dalam bola basket pada club Basket Tunas Rejang Lebong, sehingga dapat disimpulkan bahwa latihan kekuatan otot lengan mempengaruhi peningkatan bola yang masuk ke dalam ring basket pada tes (Free Throw) dan dapat dijadikan metode latihan untuk meningkatkan perestasi atlet.
Pengembangan model offense dan defense training bolabasket putra berbasis modifikasi permainan tradisional gobak sodor di smp negeri 5 Kota Bengkulu
Authors: Silaen Mangapul Ade Saputra , Pujianto Dian , Raibowo Septian
Published: April 2022

Tujuan penelitian adalah menggunakan permainan tradisional gobak sodor untuk meningkatkan hasil belajar offense dan defense atlet dalam ekstrakulikuler bolabasket karena belum adanya variasi latihan offense dan defense bolabasket dalam meningkatkan hasil belajar offense dan defense siswa dalam pembelajaran bola basket. Metode penelitian ini adalah penelitian dan pengembangan yang mengarah pada pengembangan produk. Data yang diperoleh hasil penelitian dan pengembangan memperoleh validasi ahli materi sebesar 86.1 % (sangat valid), dan ahli permainan tradisional sebesar 82.42% dengan hasil tersebut, dapat disimpulkan bahwa pengembangan model ofense dan defense training bolabasket putra berbasis modifikasi permainan tradisional gobak sodor di SMP Negeri 5 kota bengkulu dinyatakan dalam kategori layak dilanjutkan. Setelah melakukan uji efektifitas model latihan yang dikembangkan hanya memberikan pengaruh terhadap kemampuan passing dengan hasil 12to"> = 11.683 > 12tt"> = 2.093,namun belum optimal untuk meningkatkan kemampuan shooting dengan hasil 12to"> = 1.672 < 12tt"> = 2.093 dan dribble dengan hasil 12to"> = 1.244 < 12tt"> = 2.093. Karena keterbatasan waktu dan biaya, penelitian ini tidak sampai pada uji efektifitas defense
Introduction of the telemonitoring device Turbo+ in the management of patients suffering from asthma in Italy: a budget impact analysis
Authors: Rumi Filippo , Basile Michele , Cicchetti Americo , Contiguglia Rosario , Pentassuglia Antonella , Oliva Alessandro , Senna Gianenrico , Bonavia Marco , Scarpelli Francesco , Benvenuto Marco
Published: April 2022

Introduction: Adherence to long-term asthma control drugs is one of the key factors in improving disease management among patients with asthma. Poor adherence to long-term therapies significantly compromises the effectiveness of treatment and represents a problem in controlling the disease in terms of quality of life and economic impact. A budget impact analysis has been developed taking into account that Turbo+ technology (electronic monitoring device) can increase adherence to therapy in patients suffering from asthma.
Methods: Coherently with the budget impact model methodology, we developed two different scenarios. One represents the clinical practice assuming a constant market share of 0,99% for Turbo+ and the other one assumes an incremental market share of Turbo+ over the time horizon considered. An increase in adherence to therapy will likely correspond to a reduction of exacerbations and a lower rate of hospitalizations, thus generating savings in terms of use of health resources.
Results: The differential analysis shows an incremental saving in terms of resources absorbed by the National Health Service (NHS) over the time horizon considered. In the first year the savings are equal to € 795,658.64 and in the fifth year they are equal to € 3,520,636.34 for a total of resources saved in 5 years of € 10,882,028.50.
Conclusions. The model shows how the diffusion of the Turbo+ programme can lead to savings in terms of health resources consumed by the NHS. Further analyses with new real-world data on adherence in asthmatic patients could be useful in confirming the results of the present analysis.
EFEKTIFITAS JUS SEMANGKA DAN JUS MENTIMUN TERHADAP PENURUNAN TEKANAN DARAH LANSIA PENDERITA HIPERTENSI
Authors: Awaluddin Awaluddin , Yuliana Yuliana
Published: April 2022

Hypertension is one of the biggest health problems faced in the world. The purpose of this study was to determine the effectiveness of watermelon juice and cucumber juice on reducing blood pressure in the elderly with hypertension. The research method uses a quasi-experimental design with a two group pre-post test design. This research was conducted at the Sidomulyo Inpatient Health Center, Pekanbaru with a total of 20 respondents. Data analysis used dependent t test. The results showed that the average blood pressure before and after consuming watermelon juice was 147.62/90.78 mmHg and 144.16/89.54 mmHg. Meanwhile, the average blood pressure before and after consuming cucumber juice was 148.68/91.52 mmHg and 145.24/91.52 mmHg. There is a significant effect on changes in blood pressure in the elderly with hypertension with a p-value of 0.000. Researchers recommend consuming watermelon juice and cucumber juice to help reduce blood pressure.Keywords: Cucumber, Elderly, Hypertension, Juice, Watermelon.
NUSANTARA DARI SATU KAWASAN SAMPAI NAMA IBU KOTA NEGARA
Authors: Amanan Amanan
Published: April 2022

The Southeast Asia region we know today, in ancient times known as "Nusantara". The word "Nusantara" was first uttered by Patih Amangkubhumi or Gajah Mada. This name is used to refer to the area of islands (Gugusan Pulau-pulau) which is found in Southeast Asia today, the whole race (there is) is called the Malay race and the whole island is also called "Gugusan pulau-pulau Melayu". (Hamka, 2002: 657). According to M.Sarip, the name "Kutai Kartanegara" only existed at the end of the 13th century before it was also called Nusantara. If at the present time President Jokowidodo gives the name of the new State Capital (IKN) of the Republic of Indonesia the name Nusantara, the naming can not only revive or popularize the name but also restore the name, both as the name of an area that was popular in the past as well revive the name of an area in East Kalimantan that was popular in ancient times.Keywords: Archipelago, Region, Capital City, Country
HUBUNGAN KEMAMPUAN DAN MOTIVASI KERJA DENGAN PRESTASI KERJA PERAWAT PELAKSANA DI RUANG RAWAT INAP RUMAH SAKIT CAMATHA SAHIDYA KOTA BATAM TAHUN 2021
Authors: Amelia Cevy , Sarmini Sarmini
Published: April 2022

Work performance is related to the ability to work and motivation in carrying out work. Based on the presurvey, it was obtained interviews from 11 nurses who said that some of them had participated in research that supported their work and were motivated because they had just finished their education, but some nurses were less motivated because they felt that the reward had not been noticed and did not know what the work assessment was like. The purpose of this research is to know the relationship between ability and work motivation with a cross-sectional approach. The population in this study were all nurses in the inpatient room totaling 52 people. Sampling using total sampling. The research site was at Camatha Sahidya Hospital, Batam City on June 24 – August 12. Collecting data using a questionnaire adopted from Wahyudi (2010) regarding ability while a questionnaire about motivation and achievement was adopted from Adryani (2012). This study used univariate (frequency distribution) and bivariate (chi-square) analysis. The results obtained that more than half of the implementing nurses have the ability in the high category and more than half with the low category on work motivation and work performance. Furthermore, there is a relationship between ability and work performance (p Value 0.000) and there is a relationship between work motivation and work performance (p Value 0.009). Based on the conclusions of the researchers, it is recommended for hospital management to continue to maintain and improve the work motivation of implementing nurses and complete the supporting needs in improving nursing services, work motivation of nurses in carrying out their duties by creating a system of rewards that provide feedback on the performance that has been carried out by nurses.Keywords: Ability, Work Motivation, Work Performance
PENGELOMPOKKAN BERITA KESEHATAN PADA SOSIAL MEDIA TWITTER DENGAN METODE K-MEANS CLUSTERING
Authors: Anita Anita , Oliando Jeffer
Published: April 2022

Twitter is one of the most influential social media in the world with 15.7 million users in Indonesia and is ranked 6th as the country with the most Twitter users. Besides being used as social media, Twitter is also used as a medium to read or send news. News information that continues to increase causes users to have difficulty in finding certain news information. One solution that can be applied to overcome this problem is through clustering of news information on Twitter. In this study, the researcher used quantitative research with the K-Means Clustering method, which is one of the clustering methods used in grouping data. The data used in this study is a dataset taken from the UCI Machine Learning Repository, namely Health News in Twitter Data Set as many as 14,970 tweet data. The results showed that the determination of the best cluster using the Elbow method on the dataset resulted in empirical evidence that the best cluster was K=3. The results of grouping health news on Twitter social media using the K-Means Clustering method with K=3 resulted in the number of clusters, namely C1 as many as 4,991 data tweets, C2 as many as 4,482 tweets data, and C3 as many as 5,497 tweets.Keywords: Health News Grouping; Twitter Social Media; Elbow Method; K-Means Clustering Method.
PERBAIKAN KERUSAKAN PERKERASAN JALAN MENGGUNAKAN MANUAL DESAIN PERKERASAN JALAN 2017 (MDP JALAN 2017) (STUDI KASUS : JL. LINTAS PADANG – ALAHAN PANJANG)
Authors: Refi Ahmad , Faramida Suci
Published: April 2022

Abstrak: Kerusakan pada jalan menyebabkan ketidak nyamanan dan berbahaya dalam berkendara, seperti kerusakan yang terjadi pada Jl. Lintas Padang – Alahan Panjang yang merupakan jalan Kolektor Primer yang menghubungkan Ibu Kota Propinsi ke Kota Kabupaten/Kotamadya. Kerusakan pada jalan dapat menghambat fungsi jalan tersebut sehingga harus segera diatasi dengan melakukan perbaikan pada kerusakan jalan yang terjadi. Tujuan penelitian ini untuk mengetahui jenis kerusakan dan penyebab kerusakan jalan serta cara mengatasinya.Manual Desain Perkerasan Jalan 2017 (MDP Jalan 2017) merupakan metode yang akan digunakan dalam penelitian ini sebagai rujukan utama, selain itu akan digunakan beberapa metode lainnya seperti metode Bina Marga 1990 digunakan sebagai analisa dari kerusakkan jalan, dan pentuan nilai CBR dari test DCP, dan metode Perbaikan Standart Bina Marga 1995 digunakan sebagai perbaikan kerusakan jalan sebelum dilakukan overlay, dan untuk desain overlay digunakan metode Analisa Komponen 1987 dan MDP Jalan 2017.Berdasarkan analisa yang dilakukan didapat total angka kerusakan adalah 17 sehingga nilai Urutan Prioritas (UP = 9  7) dengan program pemeliharaan rutin. Perhitungan nilai CBR adalah 3,625% dan nilai DDT adalah 4,105. Untuk perbaikan jalan sebelum dilakukannya overlay mengacu pada metode Perbaikan Standart Bina Marga 1995. Desain tebal overlay dengan metode Analisa Komponen 1987 didapatkan tebal overlay 10 cm dengan bahan Laston sedangkan hasil dari MDP Jalan 2017 didapat tebal overlay 10 cm dengan bahan AC BC normal atau AC BC modifikasi, sehingga solusi overlay digunakan hasil MDP Jalan 2017. Kata Kunci : Kerusakan jalan, Perbaikan jalan, Overlay, MDP Jalan 2017, Analisa Komponen 1987, Bina Marga 1990, Bina Marga 1995, CBR.
Agency-First Epistemology of Psychedelics
Authors: Bortolotti Lisa , Murphy-Hollies Kathleen
Published: April 2022

Letheby’s book is an engaging and crystal-clear exploration of the philosophical issues raised by the use of psychedelic drugs. In this paper, we focus on the epistemological issues Letheby examines in chapter 8 and argue that his analysis requires an agency-first approach to epistemic evaluation. On an agency-first approach, epistemic evaluation is about identifying the skills agents needs to acquire in order to pursue and fulfil their epistemic goals.
Positive Affect and Letheby's Naturalization of Psychedelic Therapy
Authors: Hoffman Sarah
Published: April 2022

Letheby’s naturalistic theory of psychedelic therapy argues that the therapeutic power of psychedelics lies in their ability to allow individuals “to discover the contingency, mutability and simulatory nature of their own sense of identity and habitual modes of attention.” The general shape of this project is persuasive; it is hard to see how the claim that successful therapy must involve changes to the self could be objected to, and Letheby sketches a consistent, if speculative, picture of psychedelic experience. But the role of affect in psychedelic therapy is insufficiently explored by Letheby as a comparison to MDMA-assisted therapy indicates. This comparison further suggests that Letheby’s reliance on a particular conceptualization of ego dissolution experiences is in need of further explanation and justification.
Serotonin, Predictive Processing and Psychedelics
Authors: Colombo Matteo
Published: April 2022

Letheby’s "Philosophy of Psychedelics" relies on Predictive Processing to try and find unifying explanations relevant to understanding how serotonergic psychedelics work in psychiatric therapy, what subjective experiences are associated with their use and whether such experiences are epistemically defective. But if Predictive Processing lacks genuinely explanatory unifying power, Letheby’s account of psychedelic therapy risks being unwarranted. In this commentary, I motivate this worry and sketch an alternative interpretation of psychedelic therapy within the Reinforcement Learning framework.
Stepping through the Psychedelic Looking-Glass
Authors: Lyon Aidan , Farennikova Anya
Published: April 2022

What makes psychedelic psychotherapy work? Is it the induction of psychedelic experience, with its distinct patterns of hallucinations and insights, or is it the neural ‘shakeup’ that moves the brain out of its regular mode of functioning and into a more disordered state? We consider the role that attention-related phenomenological changes play in psychedelic transformation and psychotherapy. We review Letheby’s account of psychedelic psychotherapy, which appeals to increases in phenomenal opacity as the central mechanism of psychotherapeutic transformation. We argue that there is an alternative vehicle of psychedelic transformation that this account overlooks, involving radically transparent experiences. We outline the common kinds of phenomenal transparency shifts typical of psychedelic experiences, and argue that in many cases, such shifts are responsible for the psychotherapeutic benefits. This argument motivates an alternative approach to possible mechanisms of psychedelic self-transformation, and opens up a new venue of empirical research into the role of attention and phenomenology in psychedelic psychotherapy.
What Gets Tweeted Gets Done? Gubernatorial Agenda-Setting and State Policymaking
Authors: Ausmus Smith Sarah , Russell Annelise
Published: April 2022

Increasingly, social media plays a central, agenda-setting role throughout both the campaign where candidates are able to aggregate their policy priorities for journalists and co-partisans. We assess whether candidates’ agenda-setting behavior online resembles the policy agenda of the legislature that a future governor is slated to collaborate with. We analyze the relationship between gubernatorial candidates’ policy priorities on Twitter and policy priorities captured by legislative activity, using a data set of gubernatorial candidate tweets from 2008 to 2018 (Duell 2021) and state legislative bill introductions (Garlick 2020). We find a consistent set of state policy priorities between what issues winning gubernatorial candidates talk about and legislature activity, suggesting that even beyond institutional differences, the policy priorities between incoming governors and the legislature are by similar, national political climate dynamics. This effect continues-regardless of a governor’s institutional power or margin of victory, suggesting that it’s a question of political context.
On Robin's criterion for the Riemann Hypothesis
Authors: Vega Frank
Published: April 2022

Robin's criterion states that the Riemann hypothesis is true if and only if the inequality $\sigma(n)5040$, where $\sigma(n)$ is the sum-of-divisors function of $n$ and $\gamma\approx 0.57721$ is the Euler-Mascheroni constant. We call this inequality, the Robin inequality. In 2022, Vega stated that the possible existence of the smallest counterexample $n>5040$ of the Robin inequality implies that $q_{m} > e^{31.018189471}$ and $(\log n)^{\beta} < 1.03352795481\times\log(N_{m})$, where $N_{m} = \prod_{i = 1}^{m} q_{i}$ is the primorial number of order $m$, $q_{m}$ is the largest prime divisor of $n$ and $\beta = \prod_{i = 1}^{m} \frac{q_{i}^{a_{i}+1}}{q_{i}^{a_{i}+1}-1}$ when $n$ must be an Hardy-Ramanujan integer of the form $\prod_{i=1}^{m} q_{i}^{a_{i}}$. Based on that result, we obtain a contradiction just assuming the existence of such possible smallest counterexample $n > 5040$ for the Robin inequality. By contraposition, we show that the Riemann hypothesis should be true.
The Main Changes in the Russian Legislation in Science and Technology in 2021
Authors: Dashkova Maria
Published: April 2022

Introduction. Currently, in the context of the ongoing coronavirus pan­demic, major changes are taking place, including in the scientific and technical area. The law, as a social institution, also undergoes trans­formations determined by internal and external factors. However, such changes, as a result of which the legislation changes, do not always fully reflect the dynamics and orientation of social processes. In this regard, the purpose of this study is to identify important changes in the Russian legislation in the scientific and technical area for 2021. The subject of the study is the main changes in the Russian legislation in the field of science and innovation that occurred in the period from January to December 2021. Monitoring Tools. The methodological basis is the dialectical method. The study employs general scientific (analytical, systematic, functional), special-purpose (sociological), and specific scientific (formal legal, the method of interpretation of legal rules) methods. The materials collected as part of the analysis are con­ditionally divided in this article in the following areas: public adminis­tration in the scientific and technical field, state policy in the scientific, technical and innovative areas, the results of intellectual activity in the scientific and technical field and the organisation of the activities of the scientific field and the field of higher education. Results. The anal­ysis of legislative changes carried out in these areas will be useful both for lawyers who apply these laws, and for researchers or teachers of higher education who encounter the provisions of the regulations in question in their professional activities Conclusion. Based on the re­sults of this article, it is concluded that most of the changes that have affected the scientific and technical sphere relate to changes in by-laws that specify the norms of laws, taking into account the decisions made by the President of the Russian Federation and the Government of the Russian Federation.
Study on Stress Sensitivity of Ultra-Low Permeability Sandstone Reservoir Considering Starting Pressure Gradient
Authors: Luo Xiang , Wang Xiujuan , Wu Zhonghu , He Tongtong , Qiu Xiangliang , Yuan Fang , Tan Chengqian
Published: April 2022

When studying the influence of nonlinear seepage on the water flooding development of ultra-low permeability reservoirs, it is difficult to accurately characterize the nonlinear seepage state of ultra-low permeability reservoirs using conventional reservoir numerical simulation methods. A large number of field development and tests in the oil fields show that there are indeed starting pressure gradients and stress sensitivity effects in ultra-low permeability sandstone reservoirs. In this study, taking the tight sandstone of the Chang 6 Member in the Yanchang Formation as an example, the rock displacement vector was utilized to equivalently characterize the stress-sensitive effect of the reservoir based on a novel numerical simulation software tNavigator. Furthermore, the starting pressure gradient and the feasibility of a new stress-sensitive equivalent characterization method were verified combining the poroelastic media physics equations. In addition, we systematically studied the impact of stress-sensitive effects on oil well productivity under the influence of starting pressure gradient and considering petrophysical properties. The results show that the existence of the starting pressure gradient can improve the stress sensitivity of the matrix reservoir. Considering the starting pressure gradient, when the rock shear modulus is 14.29 GPa, the cumulative oil production decreases by 4.1%; when the rock shear modulus is 11.36 GPa, the cumulative oil production decreases by 11.2%. Finally, a numerical simulation was conducted with Block B in the Zhouwan-Wugucheng area, and the model can accurately predict the reservoir stress sensitivity based on the starting pressure gradient. When both the starting pressure gradient and stress sensitivity are considered, the crude oil recovery degree of the target layer decreases by 11.7%; when only the starting pressure gradient is considered, the crude oil recovery degree decreases by 8.8%; and when only the stress sensitivity is considered, the crude oil recovery degree decreases by 0.5%.
Back-End, CMOS-Compatible Ferroelectric FinFET for Synaptic Weights
Authors: Falcone Donato Francesco , Halter Mattia , Bégon-Lours Laura , Offrein Bert Jan
Published: April 2022

Building Artificial Neural Network accelerators by implementing the vector-matrix multiplication in the analog domain relies on the development of non-volatile and tunable resistances. In this work, we describe the nanofabrication of a three-dimensional HZO—WOx Fin Ferroelectric Field Effect Transistor (FinFeFET) with back-end-of-line conditions. The metal-oxide channel (WOx) is structured into fins and engineered such that: 1) the current-voltage characteristic is linear (Ohmic conduction) and 2) the carrier density is small enough such that the screening length is comparable to one dimension of the device. The process temperature, including the HZO crystallization, does not exceed 400°C. Resistive switching is demonstrated in FinFeFET devices with fins dimension as small as 10 nm wide and 200 nm long. Devices containing a single fin that are 10 nm wide are characterized: 5 µs long voltage pulses in the range (−5.5 and 5 V) are applied on the gate, resulting in analog and symmetric long term potentiation and depression with linearity coefficients of 1.2 and −2.5.
Genetic Etiology of Neonatal Diabetes Mellitus in Vietnamese Infants and Characteristics of Those With INS Gene Mutations
Authors: Ngoc Can Thi Bich , Dung Vu Chi , De Franco Elisa , Lan Nguyen Ngoc , Thao Bui Phuong , Khanh Nguyen Ngoc , Flanagan Sarah E. , Craig Maria E. , Hoang Nguyen Huy , Dien Tran Minh
Published: April 2022

Background

Neonatal diabetes mellitus (NDM) is a rare (1:90,000 newborns) but potentially devastating metabolic disorder characterized by hyperglycemia combined with low levels of insulin. Dominantly-acting insulin (INS) gene mutations cause permanent NDM through single amino acid changes in the protein sequence leading to protein misfolding, which is retained within the endoplasmic reticulum (ER), causing ER stress and β-cell apoptosis. Over 90 dominantly-acting INS gene mutations have been identified in individuals with permanent NDM.

Patients and Methods

The study included 70 infants diagnosed with NDM in the first year of life between May 2008 and May 2021 at the Vietnam National Children’s Hospital. Sequencing analysis of all the genes known to cause NDM was performed at the Exeter Genomic Laboratory, UK. Clinical characteristics, molecular genetics, and annual data relating to glycemic control (HbA1c) and severe hypoglycemia of those with INS mutations were collected. The main outcomes of interest were HbA1c, daily insulin dose, growth, and cognitive/motor development.

Results

Fifty-five of 70 infants (78.5%) with NDM harbored a mutation in a known disease-causing gene and of these, 10 had six different de novo heterozygous INS mutations. Mean gestational age was 38.1 ± 2.5 weeks and mean birth weight was 2.8 ± 0.5 g. They presented with NDM at 20 ± 17 weeks of age; 6/10 had diabetic ketoacidosis with pH 7.13 ± 0.26; plasma glucose level 32.6 ± 14.3 mmol/l and HbA1C 81 ± 15% mmol/mol. After 5.5 ± 4.8 years of insulin treatment, 9/10 have normal development with a developmental quotient of 80-100% and HbA1C 64 ± 7.3 mmol/mol, 9/10 have normal height, weight, and BMI on follow-up.

Conclusions

We report a series of Vietnamese NDM cases with dominant INS mutations. INS mutations are the third commonest cause of permanent NDM. We recommend screening of the INS gene in all children diagnosed with diabetes in the first year of life.