bluuebunny/crossref_metadata_2025 huggingface dataset:
Modern approaches to conservative therapy of polycystic kidney disease
Authors: Rudenko T. E , Bobkova I. N , Stavrovskaya E. V
Published: August 2019

Polycystic kidney disease (PKD) is a genetically determined pathological process associated with the formation and growth of cysts originating from the epithelial cells of the tubules and/or collecting tubes. PBP is represented by two main types - autosomal dominant (ADPKD) and autosomal recessive PKD (ARPKD), which are different diseases. The main causes of ADPKD are mutations of the PKD1 and PKD2 genes, which encode the formation of polycystin-1 and polycystin-2 proteins. ARPKD-linked mutation in the gene PKHD1, leads to total absence or defective synthesis of receptor protein primary cilia - fibrocystin. There are relationships between the structural and functional defects in the primary cilia and PBP. Mechanisms of cysts formation and growth include a) mutations of polycystines genes located on the cilia; b) increased activity of renal intracellular cAMP; c) vasopressin V2 receptors activation; d) violation of the tubular epithelium polarity (translocation of Na,K-ATPasa from basolateral to apical membrane); e) increased mTOR activity in epithelial cells lining renal cyst. The most promising directions of ADPKD therapy are blockade of vasopressin V2 receptors activation, inhibition of mTOR signaling pathways and reduction of intracellular cAMP level. The review presents clinical studies that assessed the effectiveness of named drugs in ADPKD.
Personalized approach for direct oral anticoagulant prescription: from theory to practice
Authors: Skripka A I , Kogay V V , Listratov A I , Sokolova A A , Napalkov D A , Fomin V V
Published: August 2019

Data on possibilities of personalized approach for direct oral anticoagulants (DOAC) choice in patients with atrial fibrillation are presented in the article. We also review clinical and fundamental studies and future perspectives on pharmacogenetic and pharmacokinetic tests to predict the efficacy and safety of DOAC.
Clinical case of IgG4-related disease in a patient with Burkitt lymphoma
Authors: Feydorova T I , Vinokurova L V , Dvoynikov S Yu , Mikheeva O M , Dudin G A , Akopova A O
Published: August 2019

The article provides a case of primary diagnosis of IgG4-related disease in a patient with Burkitt lymphoma.
The role of translocations involving c-MYC/8q24, BCL2/18q21 and/or BCL6/3q27 genes in patients with follicular lymphoma. Retrospective analysis of single - centre data
Authors: Misyurina A E , Kravchenko S K , Kovrigina A M , Magomedova A U , Plastinina L V , Obukhova T N , Misyurin A V , Misyurin V A , Grebenuk L A , Babaeva F E , Baryakh E A , Vorobiev A I
Published: August 2019

Aim of the issue was to compare clinical characteristics and treatment results of patients with follicular lymphoma (FL) with translocations involving loci of c-MYC/8q24, BCL2/18q21 and/or BCL6/3q27 genes and patients with high - grade B-cell lymphoma [High - grade B-cell lymphoma (HGBL), double - hit (DH)]. Materials and methods. Since 2004 to 2017 years in National Research Center for Hematology 12 patients with high - grade B-cell lymphoma double - hit (HGBL DH) and 6 FL patients with translocations involving c-MYC and BCL2 and/or BCL6 had been treated. We performed a comparative analysis of clinical characterisctics in both groups. As primary endpoints was assessed frequency of complete remission (CR) or progressive disease (PD); as secondary endpoints - overall (OS) and event - free survival (EFS). Results. 5 patients with HGBL DH had c-MYC/BCL6, 7 - c-MYC/BCL2 rearrangements; 2 patients with FL had c-MYC/BCL2, 3 - c-MYC/BCL6, 1 - c-MYC/BCL2/BCL6 rearrangements. FL was represented by grade 3A in 2, grade 3B - in 4 cases, 3 of them had large - cell transformation. In HGBL DH and FL patients had no significant differences in clinical characteristics. The majority of patients had a widespread tumour, increased LDH activity, high frequency of extranodal and bone marrow involvement. Ki-67 expression level was lower in patients with FL (p
Clinical observation of a patient with thrombotic thrombocytopenic purpura with renal and intestinal lesions
Authors: Stolyar A G , Avdonin P V , Valamina I E , Stolyarevich E S
Published: August 2019

The article presents a brief description of a rare disease - thrombotic thrombocytopenic purpura (Moshkovits - disease), which is based on the deficiency of ADAMTS-13 metalloproteinase, leading to the development of thrombotic microangiopathy with the defeat of vital organs. The article also describes the clinical observation of a patient with the Moshkovits - disease. The features of the above observation are involvement in the pathological process of the kidneys and intestines, while in the classical descriptions of the disease there is a predominant lesion of the Central nervous system, as well as the genetic form of the disease.
Difficulties evaluating hematological response in patients with multiple myeloma and dialysis - dependent renal impairment
Authors: Rekhtina I G , Mendeleeva L P , Soboleva N P
Published: August 2019

Aim: to determine serum free light chains (FLC) level by patients with multiple myeloma (MM) and dialysis - dependent renal impairment in which the amount Bence Jones (BJ) protein in the urine met the criteria of hematological response. Patients and methods: This study included 13 MM with dialysis - dependent renal impairment patients (estimated glomerular filtration rate < 10 ml/min), whose urine BJ protein content was less than 200 mg/day after antimyeloma therapy (including 11 patients whose urine BJ protein content was less than 100 mg/day). Results. The median serum concentration of monoclonal FLC was 608.7 (298-8380) mg/l. Thus, with trace amounts BJ protein in the urine serum content monoclonal FLC varied 28 times with the same degree of severity of renal failure. In patients with oliguria serum SLC content was significantly higher than in normal diuresis (1109 and 307 mg/L; p
Somatic mutation of the V617F JAK2 gene in patients of the cardiovascular diseases
Authors: Olkhovskiy I A , Gorbenko A S , Stolyar M A , Grischenko D A , Tkachenko O A , Martsinkevich T L
Published: August 2019

The JAK2 V617F somatic mutation is one of the most frequent markers of CHIP (clonal hematopoiesis of indeterminate potential). CHIP is characterized by the presence of a myeloid cells clone in peripheral blood in the absence of the sufficient reasons to diagnose the hematologic disease. The CHIP is proposed as a potential independent risk factor for vascular pathology. The aim of this study is to identify carriers of JAK2 V617F mutation among patients admitted for planned hospitalization at the Federal Center of Cardiovascular Surgery of Krasnoyarsk. Materials and methods. The study included 930 venous blood samples. JAK2 V617F mutation was detected by using the allele - specific real time polymerase chain reaction. Results. JAK2 V617F mutation was detected in 15 (1.6%) patients, but only two of them had blood cell count that could cause a hematological disease to be suspected. Conclusion. The inclusion of the JAK2 V617F mutation detection in the complex of laboratory tests of the cardiovascular patients can facilitate the timely identification of patients with increased thrombotic risk, as well as the timely diagnosis of myeloproliferative diseases.
Epidemiology of multiple myeloma in city Moscow
Authors: Vinogradova O Yu , Ptushkin V V , Chernikov M V , Kochkareva Yu B , Zherebtsova V A
Published: August 2019

Aim. To study the epidemiology of multiple myeloma in the city of Moscow and compare the results obtained with data from similar studies in other countries. Materials and methods. The study is based on information from a database of case histories of 3942 patients suffering from symptomatic MM, residents of the city of Moscow, which is maintained at the Hematologic Moscow City Center of S.P. Botkin Municipal Clinical Hospital. The control of the completeness of inclusion was carried out by cross - comparison with the data of the Moscow Cancer Register and the Register of Program 7 (beginning in 2019 - 12) of Highly Expensive Nosologies. The assessment was made according to data as of January 1, 2019. The calculations were carried out taking into account the data of Rosstat at the beginning of 2019 on the population of Moscow in different gender and age categories. Results. Among the 3942 patients with active MM 1707 men - 43% and 2241 women - 57%, the median of the current age was 68 (28-94) years. The median time of observation of patients since the diagnosis of the disease 34 (1-423) months. The peak incidence was in the age range of more than 60 years. There were no significant differences in gender ratio in different age strata with a breakdown of 10 years. The number of cases of newly diagnosed MM per year for the period from 2009 (n=219) to 2018 (n=385) increased by 75.8%. At the same time, the demonstrated increase in the incidence rate for the described period turned out to be fair only for groups of patients over 50 years old, with the maximum increase in this indicator over the described period in the age range of 60-69 years. This is mainly due to the increase in life expectancy in Moscow in recent years. The study demonstrated that over the past 10 years, the average annual mortality rate from MM has decreased in Moscow, and as a result, its prevalence has increased. The rate of 2-year overall survival of patients with MM was 76%, 5-year - old - 49%, 10-year - old - 27%. The median overall survival of patients under the age of 65 when diagnosing the disease was 79 months, and 48 months. The distribution of patients within international classifications was consistent with international data. Conclusions. The study revealed a significant dynamic of the epidemiological situation concerning MM in Moscow. Over the past 10 years there has been an increase in the incidence of MM, as a result of an increase in the life expectancy of the population. The use of modern diagnostics and therapy of MM in real clinical practice has led to a significant reduction in mortality. Due to these factors, an increase in the prevalence of MM in Moscow has taken place, and this process will no doubt progress in the future.
Role of the intensive care in treatment of patients with acute myeloid leukemia
Authors: Bazhenov A V , Galstyan G M , Parovichnikova E N , Troitskaya V V , Kuzmina L A , Fidarova Z T , Gribanova E O , Makhinya S A , Latyshkevich O A , Chabaeva U A , Kulikov S M , Savchenko V G
Published: August 2019

Aim. Remission induction can be associate, with the life threatening complications and transfer to ICU of de novo acute myeloid leukemia (AML) patients (pts). We evaluate influence of transfer to ICU and life threatening complication on early mortality and long - tram survival of de novo AML pts. Materials and methods. Retrospective study. All de novo AML pts younger than 60 years old admitted in the National Research Center for Hematology from 2013 to 2016 years were enrolled in the study. Patients were divided into 2 groups: pts who were required ICU admission during remission induction (ICU-pts) and pts who did not require ICU admission and received chemotherapy only in hematology ward (non-ICU pts). The reasons for ICU admissions and results of life support were analyzed. Overall survival (OS) were assessed by the Kaplan-Meier method, long rank value p
CNS involvement and the feasibility of intratecal chemotherapy administration in patients with a nodal form of diffuse large B-cell lymphoma not otherwise specified. Data of prospective study
Authors: Magomedova A U , Misyurina A E , Mangasarova J K , Gorenkova L G , Margolin O V , Fastova E A , Kravchenko S K
Published: August 2019

Aim of the issue was to determine indications for intratecal chemotherapy drugs administration to prevent relapse of diffuse large B-cell lymphoma (DLBCL) with central nervous system (CNS) involvement. Materials and methods. Since January 2009 to December 2018 102 patients with primary nodal DLBCL over 18 years old were treated in the National Research Center for Hematology, Moscow, Russian Federation. Diagnosis were established in all cases according to histological and immunohistochemical studies which made it possible to exclude the transformation of mature B-cell lymphoma into DLBCL. Results. Isolated leptomeningeal involvement of CNS in the debut of the disease was detected in 1 (0.98%) out of 102 patients with DLBCL. Focal brain tissue involvement was not detected in any patient. More than half of the patients (54%) had a high risk of disease recurrence or progression with CNS involvement: in 8 (7.8%) patients had kidney/adrenal involvement, in the same proportion - bone marrow involvement, paranasal sinuses involvement - in 5 (4.9 %), epidural space - in 7 (6.9%) and breast - in 5 (4.9%) of patients. In 82 (80%) patients, a non-GCB (postgerminal differentiation of B-cell analog) molecular subtype of DLBCL was determined. Conclusion. The introduction of chemotherapy drugs into the spinal canal is recommended in isolated cases of leptomeningeal involvement of CNS at the time of DLBCL onset and is carried out according to standard recommendations. Prevention of relapse with involvement of central nervous system using intratecal chemotherapy in patients with nodal form of DLBCL is not indicated due to the absence of cases with disease progression or recurrence into CNS when patients were treated with R-m-NHL-BFM-90, R-DA-EPOCH and R-CHOP protocol.
Clinical features and diagnosis of Ph - negative myeloproliferative neoplasms occurring in conjunction with the antiphospholipid syndrome
Authors: Melikyan A L , Subortseva I N , Koloshejnova E A , Gilyazitdinova E A , Shashkina K S , Gorgidze L A , Tratsevskaya Zh V , Margolin O V
Published: August 2019

Thrombosis is a serious and extremely dangerous disease that has a negative impact on the quality and longevity. Antiphospholipid syndrome (APS) is a pathology characterized by recurring venous, arterial, microvasculature thrombosis, pregnancy pathology with loss of the fetus and the synthesis of antiphospholipid antibodies. A high risk of thrombotic complications is also observed in patients with myeloproliferative neoplasms (MPN). This article presents a description of three clinical cases of Ph - negative myeloproliferative diseases, occurring in conjunction with APS. In all cases, recurrent thrombosis allowed to suspect the presence of two diseases - MPN and APS.
Russian multicenter clinical trials in acute leukemias
Authors: Parovichnikova E N , Savchenko V G
Published: August 2019

The paper describes the results of 15 consecutive Russian clinical trials in the treatment of different types of acute leukemias, conducted by Russian cooperative group within the last 27-years and included more than 25 hundred patients. It was shown that the 5-years overall survival in AML younger than 60 years patients improved from 20 to 33%, in ALL - from 38 to 65%, in APL - from 0 to 95%. The cooperative work resulted in balanced clinical recommendations and protocols, reproducible in regional hospitals. Though till now there is a big difference in the long term outcome in acute leukemias patients treated in coordinating or regional centers mostly due to much higher early death rate: 7.5-9.5% vs 18-25%. This parameter should be used as criteria of the total efficacy of hematological service in each region of Russia. It became possible within the last years to integrate the minimal residual disease monitoring into clinical trials thus providing a clue parameter for choosing the further therapy - allogeneic stem cell transplantation. Non - chemotherapeutic approach with arsenic trioxide and all - trans retinoid acid had dramatically changed the toxicity and duration of treatment with very high efficacy. The Russian cooperative group was the first that started to include pregnant women with acute leukemias into clinical trials. This prospective and prolonged experience has shown that pregnancy in acute myeloid leukemia is an extremely poor prognostic factor, but it does not influence the outcome in acute lymphoblastic leukemia.
Pure red cell aplasia of the bone marrow in combination with thymoma. A literature review and own data
Authors: Petrenko A A , Pivnik A V , Dudina G A , Dubnitskaya M G
Published: August 2019

Eight patients were observed with a rare combination of thymoma and pure red cell aplasia of bone marrow (PRCA), of which seven women were between 44 to 68 years old. The diagnosis of PRCA was established before the detection of thymoma in 1 patient, simultaneously in 3, after - in 4. Seven patients underwent timomectomy. The weight of removed thymomas was from 200 to 780 grams. Morphological type A thymoma variant (spindle cell) was installed in 2 patients, type B1 - in 2, type B2 - in 2, type B3 - in 2. Complete remissions were obtained using cyclophosphamide and cyclosporin in 5 patients, lasting from 6 months to 7 years. The results of immunological studies with the identification of non - hemolytic antibodies to the proteolytic antigen (Pr1d) on the erythrocyte membrane in 4 patients are presented. Of these, two studied patients simultaneously detected antibodies to the Pr1d antigen and the interspecific antigen of mammalian erythroblasts (IAME). It is shown that the lifespan of red blood cells are not changed. The direct Coombs test was negative in 5 patients, but with the help of aggregate hemaglutination test and enzyme immunoassay, antibodies were detected on the surface of erythrocytes. The pathogenesis of this combination of diseases remains unclear and needs to be elucidated.
Enzyme replacement therapy in adult patients with type I Gaucher disease
Authors: Ponomarev R V , Lukina E A
Published: August 2019

Enzyme replacement therapy (ERT) is the standard for the treatment of Gaucher disease (GD). A lifelong intravenous administration of a recombinant analogue of human glucocerebrosidase compensates for the functional deficiency of its own enzyme. The use of ERT has changed the clinical phenotype of GD, a severe progressive disease has been turned into the status of an asymptomatic metabolic defect. At the same time, a reduced dosing ERT regimen applied in Gaucher patients who had achieved therapeutic goals has not yet been developed.
PET/CT with 18F-fluorodeoxyglucose and 11C-methionine after autologous stem cell transplantation in multiple myeloma patients
Authors: Solovev M V , Mendeleeva L P , Firsova M V , Aslanidi I P , Mukhortova O V , Savchenko V G
Published: August 2019

Aim: to compare the results of tumor visualization when using 18F-FDG and 11C-methionine PET/CT after auto-HSCT in MM patients. Materials and methods. A prospective study included 27 MM patients subjected to 18F-FDG and 11C-methionine PET/CT on day 100 after auto-HSCT. Obtained images were visually and semi - quantitatively analyzed. Focal areas of increased uptake for every radiopharmaceutical agent (hypermetabolic foci) not associated with its physiological distribution were registered. Maximum Standardized Uptake Values (SUVmax) in pathological foci were automatically calculated for every radiopharmaceutical agent separately. PET/CT findings were compared to antitumor response achieved after auto-HSCT according to International MM Working Group criteria. Results. After auto-HSCT, the majority of patients (16/60%) achieved a complete response. Abnormal 18F-FDG uptake was registered in 37% (n=10) of patients, negative PET findings were obtained in 63% (n=17) of patients. 11C-methionine PET/CT revealed hypermetabolic foci in 67% (n=18) of patients, and there was no 11C-methionine uptake in 33% (n=9). Pathological foci of radiopharmaceutical agent uptake were 1.8 times more frequently revealed using PET/CT with 11C-methionine (p
Brain MRI-findings in Ph - negative myeloproliferative disorders
Authors: Tanashyan M M , Melikyan A L , Kuznetsova P I , Raskurazhev A A , Shabalina A A , Konovalov R N
Published: August 2019

Myeloproliferative disorders (MPD) are accompanied by a high proportion of thrombotic complications, which may lead to cerebrovascular disease (CVD). Aim. To describe MRI-findings in patients with Ph - negative MPD and evaluate any cerebrovascular disease. Materials and methods. We included 104 patients with Ph - negative MPD (age varied between 20 and 58) with clinical correlates of cerebrovascular pathology. Results. Brain MRI showed post - stroke lesions in 20% of patients (7 hemispheric infarcts due to thrombotic occlusion of one of the large cerebral arteries, 14 - cortical infarcts). 37 patients (36%) had vascular cerebral lesions. Cerebral venous sinus thrombosis occurred in 5 patients - in 7% (n=3) of patients with polycythemia vera and 5% (n=2) - in patients with essential thrombocythemia. The incidence of vascular cerebral lesions was associated with higher levels of the following: erythrocyte, platelet count, fibrinogen, and with the decrease in fibrinolytic activity, as well. Conclusion. The pioneering results of the study include the description and analysis of brain MRI-findings in patients with Ph - negative MPD. The underlying mechanisms of cerebrovascular pathology in these patients are associated with certain blood alterations (particularly, hemorheology) which present a major risk factor.
Molecular diagnosis angioimmunoblastic T-cell lymphoma
Authors: Chernova N G , Sidorova Y V , Smirnova S Y , Ryzhikova N V , Nikulina E E , Kovrigina A M , Sinitsyna M N , Sudarikov A B
Published: August 2019

Aim: to determine molecular diagnostics routine for different tissue samples in angioimmunoblastic T-cell lymphoma. Materials and methods. Molecular studies were performed for 84 primary AITL patients. The median age was 61 year (29-81); the male to female ratio was 48/36. T-cell and B-cell clonality was assessed by GeneScan analysis of rearranged T-cell receptor (TCRG, TCRB) and immunoglobulin heavy chain genes. For the quantitative determination of cells with RHOA G17V mutation real - time polymerase chain reaction (PCR) with allele - specific LNA modified primers was used. Results. In lymph nodes rearrangements of T-cell receptor genes were determined in 76 (90.5%) of 84 patients and were absent in 8 (9.5%) cases. Identification of the same clonal products of the TCRG and TCRB genes in the lymph node and in peripheral blood and/or bone marrow indicated the prevalence of the tumor process and was observed in 64.7% of patients. Clonal products in peripheral blood and/or bone marrow different from those in the lymph node indicated reactive cytotoxic lymphocyte population and were noted in 58.8% of AITL cases. Simultaneous detection of T- and B-cell clonality in the lymph node was observed in 20 (24.7%) of 81 patients. Cells with RHOA G17V mutation were detected in lymph node in 45 (54.9%) of 82 patients. The use of allele - specific PCR with LNA modified primers revealed presence of the tumor cells in peripheral blood in 100% and in bone marrow in 93.9% of patients with G17V RHOA mutation in the lymph nodes. Conclusion. The validity of different molecular assays performed on certain tissue samples for the diagnosis of angioimmunoblastic T-cell lymphoma has been evaluated. Quantitative allele - specific PCR assay for RHOA G17V mutation based on LNA modified primers possesses sufficient sensitivity for tumor process prevalence evaluation and minimal residual disease monitoring.
Impact of Corporate Social Responsibility Awards on Share Prices
Authors: Mahmood Zeeshan , Iqbal Javed , Ali Waris , Aamir Muhammad
Published: August 2019

This paper provides empirical evidence to evaluate the business case of corporate social responsibility. In contrast to former studies, we choose to examine the relationship between corporate social responsibility awards and share prices. We examined this relationship in the contextual setting of Pakistan, where several award schemes are operating to reward CSR performance. An event study methodology was adopted to investigate the impact of award announcement on the abnormal return of TOP 100 companies listed on the Pakistan Stock Exchange. A daily price for each company was collected during the estimation window of 120 days before the event window and an event window of 3 days [-1, 0, 1]. Our analysis shows that the overall announcement of CSR awards has an insignificant impact on share price.
Information Behavior of Medical Doctoral Students in Burkina Faso
Authors: Ouangré Zoé Aubierge
Published: August 2019

There are few studies on the information behavior of students in Southern countries, particularly those at the graduate level. We present the results of a survey of 279medical doctoral students in Burkina Faso on their behavior in the search for information related to their research activities.
Partager l’information pour dépasser les frontières institutionnelles et professionnelles ou le défi des réseaux de santé dans le système de santé français
Authors: Bourret Christian
Published: August 2019

Les solutions envisagées à la crise du système de santé reposent sur un meilleur partage de l’information. En France, les réseaux de santé veulent dépasser les frontières entre la médecine de ville et l’hôpital en développant de nouvelles pratiques coopératives en association avec les patients, notamment pour réduire l’asymétrie d’information. Solving the Health System crisis requires an improvement in information sharing. In France, Health Networks attempt to overcome the frontiers between primary care and hospitals. The asymmetry of information is also expected to be reduced through new cooperative practices developed in collaboration with patients.
The Many Facets of Document Importance: A Case Study of Office Workers
Authors: Paré François-Xavier
Published: August 2019

This paper examines the notion of document importance in personal information management. Based on a literature review and the results of a previous study, we propose a typology of the factors that can affect office workers’ perception of the importance of electronic documents. A methodology for testing and refining this model is then described.Cet article examine la notion d’importance relative des documents dans la gestion personnelle de l’information. En se basant sur une revue de la littérature ainsi que sur les résultats d’une précédente étude, nous proposons une typologie des facteurs pouvant conduire un employé de bureau à considérer un document numérique comme important. Une méthodologie visant à tester et raffiner ce modèle est ensuite proposée.
The Information Needs of Homeless Library Patrons in New York City
Authors: Yemini–Halevi Gali
Published: August 2019

Field study discovered some information needs of homeless people visiting public libraries in New York. During summer 2006, reference areas of New York public libraries were observed unobtrusively to track homeless patrons’ use of library resources and services. Findings include the use of resources and services by homeless patrons groups.Une étude de terrain révèle certains besoins informationnels des itinérants visitant les bibliothèques publiques de New York. Pendant l’été 2006, les services de références des bibliothèques publiques de New York ont été observés de manière non obstructive afin de connaître les ressources et les services des bibliothèques utilisés par les itinérants. Les résultats incluent l’utilisation des ressources et des services par les groupes d’usagers itinérants.
Quality in Brazilian Academic Libraries: Proposal of Indicators from the Customers' Point of View
Authors: Vergueiro Waldomiro , De Carvalho Telma
Published: August 2019

The management of quality in academic libraries, as a management method that allows the improvement of performance, has been the object of interest for the managers of these services. In this context, the identification of indicators that may take into account the social-economical and political context that permeate the reality of the information services is essential to better adequate the quality proposals. A search aiming to identify and validate proper indicators for academic libraries in developing countries was developed by a group of researches and professionals involved with many teaching units of São Paulo Academic. Based on a bibliographic survey about the application of quality on information services, the research aimed to validate 16 indicators appointed in the literature and considered, by the research staff, as belonging to Brazilian reality (communication, access, reliability, courtesy, effectiveness/ efficiency, quality, response, tangible, reliability, security, extension, warranty, external customer satisfaction, cost/benefit and response time). From the data collection performed with 7 academic libraries in the Dentistry field, that served as environment to apply and validate the indicators, a proposal for its adequacy to the characteristics of the Brazilian academic environment was elaborated. It was concluded that the indicators tested in the dentistry libraries made possible the identification and characterization of the main elements that must be present during the evaluation of the quality of an information service of academic nature, and may be adapted and seen in the context of other environments, as well as to be used to permanently monitor the information services inserted in the Brazilian context.
A Transactional Matrix Analysis of National Attendance On International Scientific Meetings
Authors: Glänzel Wolfgang , Schlemmer Balázs , Schubert András
Published: August 2019

Scientific meetings have become increasingly important channels for scholarly communication. In this study we explore the use of an important feature of the ISI Proceedings database, namely, of information about conference location for the analysis of information flow such as relative attractivity, mobility and unidirectional or mutual affinity of countries.De plus en plus les conférences se présentent comme des outils principaux de la communication scientifiques. Dans cette étude nous cherchons comment les lieux de conférences, comme capturés dans la base de données ISI Proceedings, peuvent assister à l’analyse de la dissipation de l’information à travers des mesures comme l’attractivité relative, la mobilité et l’affinité unidirectionelle ou mutuelle des pays.
Perceptions of Affordance in an Academic Library: A Qualitative Study
Authors: Sadler Elizabeth , Given Lisa M.
Published: August 2019

Applies ecological psychology’s concept of “affordance” to graduate students’ information behaviours given design decisions made by academic librarians. Qualitative interviews explore how students perceive and use the library’s various tools (e.g., books, databases, instructional sessions, librarians, etc.), and how students’ activities reflect librarians’ perceptions of what these tools can do.Application du concept de psychologie écologique de « l’affordance » sur les comportements informationnels des étudiants de 2e cycle concernant les décisions de conception prises par les bibliothécaires universitaires. Des entrevues qualitatives explorent la manière dont les étudiants perçoivent et utilisent divers outils de la bibliothèque (par exemple : les livres, les base de données, les sessions de formation, les bibliothécaires, etc.) et la manière dont les activités des étudiants reflètent les perceptions des bibliothécaires sur ce que ces outils peuvent faire.
A Comparative Study on Feature Selection of Text Categorization for Hidden Markov Models
Authors: Yi Kwan , Beheshti Jamshid
Published: August 2019

In document representation for digitalized text, feature selection refers to the selection of the terms of representing a document and of distinguishing it from other documents. This study probes different feature selection methods for HMM learning models to explore how they affect the model performance, which is experimented in the context of text categorization task.Dans la représentation documentaire des textes numérisés, la sélection des caractéristiques se fonde sur la sélection des termes représentant et distinguant un document des autres documents. Cette étude examine différents modèles de sélection de caractéristiques pour les modèles d’apprentissage MMC, afin d’explorer comment ils affectent la performance du modèle, qui est observé dans le contexte de la tâche de catégorisation textuelle.
Is Searching the Internet Really Different? Search Process Models for Two Electronic Environments
Authors: Logan ELizabeth , Driscoll-Eagan Lori L.
Published: August 2019

A pilot study devised to explore factors contributing to searcher persistence in varying electronic environments was conducted in the usability lab at the School of Information Studies at Florida State University in the summer and fall of 1997. Subjects were students who claimed some knowledge of WWW searching and students who had completed a basic course in traditional electronic searching.
Statistical Power and Effect Size in Informative Retrieval Experiments
Authors: Nelson Michael J.
Published: August 2019

Statistical tests are used in information retrieval to test various hypotheses such as which indexing method is better or which retrieval system is better. Sometimes when using these statistical tests there is not enough evidence to reject the null hypothesis. Then either we have correctly discovered a true null hypothesis or made a type II error (probability denoted by b) and falsely accepted a . . .
Socialization of Information: A New Research Agenda
Authors: Guimaraes Maria Cristina S.
Published: August 2019

Summing up the two sides of the event information, information as a process and information as a product, Socialization of Information has emerged as a methodological perspective to bring about fresh insights on information themes. Focusing on human and social aspects of information transfer, Socialization of Information seeks to provide successful alternatives, which might improve. . .
Understanding How Experts Use Bioinformatics Resources
Authors: Bartlett Joan C.
Published: August 2019

This paper reports the preliminary findings of a study to understand how experts use bioinformatics resources. These are complex databases of gene or protein sequences, and software tools that manipulate and analyze the data. The experts were seen to follow distinct patterns of resource use, which are quite different from traditional patterns of information-seeking behaviour.
Children As Web Portal Designers: Where Do We Start?
Authors: Large Andrew , Beheshti Jamshid , Nesset Valerie , Bowler Leanne
Published: August 2019

This paper emerged from a research question concerning the most effective way to introduce children to the role of web portal designer. One approach would be for the team critically to evaluate a variety of existing children's and/or adult web portals to gain ideas before commencing the design process proper. An alternative would be to begin the design process without such a critical. . .
Constructing Sense from Uncertain and Evolving Health Information
Authors: Genuis Shelagh
Published: August 2019

This qualitative study explored individuals’ everyday life experiences as they interacted with and integrated uncertain health information mediated by formal and informal sources. Findings demonstrate that knowledge translation is a multifaceted, ongoing process of social construction. The study has implications for health literacy and shared decision-making.Cette étude qualitative explore les expériences individuelles quotidiennes dans une option d’interaction et d’intégration de renseignements médicaux incertains provenant de sources formelles et informelles. Les résultats démontrent que le transfert de connaissances est un processus de construction sociale continu à multiple facettes. L’étude a des répercussions sur la littératie en santé et la décision par consensus.
Conceptual Challenges in "Information Literacy"
Authors: Julien Heidi
Published: August 2019

This paper explores an apparent conceptual gap between pragmatic, instrumental understandings of information literacy (IL), and critical conceptions that view IL as a social information practice. These critical stances reject the notion of IL as a set of generic, uncontextualized skills, such as those articulated in several international IL standards.Cette communication explore un écart conceptuel apparent entre une compréhension pragmatique et instrumentale de la maîtrise de l’information et les conceptions critiques qui conçoivent la maîtrise de l’information comme une pratique d’information sociale. Ces critiques rejettent la notion que la maîtrise de l’information se veut un ensemble de compétences génériques et non-contextualisées tel qu’articulé dans de nombreuses normes internationales.
Sea Stacks: Contemporary Atlantic Canadian Books for Children and Teens
Authors: Dixon Nicole
Published: August 2019

This poster describes our SSHRC-funded research project, a web-based resource of Atlantic Canadian authors and books for children and young adults. The resource includes a comprehensive annotated bibliography of primary texts, author and illustrator profiles, and videotaped interviews, and showcases the process of creating the Sea Stacks web resource using Drupal.Cette affiche décrit notre projet de recherche financé par le CRSH : une ressource électronique des auteurs du Canada Atlantique de livres pour enfants et jeunes adultes. Cette ressource comprend une bibliographie annotée exhaustive des principaux textes, le profil des auteurs et des illustrateurs, des entrevues vidéo et illustre le processus de création des ressources Sea Stacks à l’aide de Drupal.
Mapping the 21st Century Information Landscape: Borders, Bridges and Byways
Authors: Rothbauer Paulette , Stevenson Siobhan , Wathen Nadine
Published: August 2019

Proceedings of the CAIS/ACSI 2009 conference.
Towards Understanding of Contextual Factors in Information Sharing Behaviors of Inter-Team Activities
Authors: Xiao Lu , Buchel Olga , Martin Jennifer , Huang Dongyan
Published: August 2019

Activities involving two or more teams to share information and make collective decisions are increasingly common. However, little has been investigated about these behaviors. We have been studying two engineering teams of different national culture to understand the contextual factors that affect the teams’ interactions and information sharing behaviors.Les activités impliquant deux ou plusieurs équipes devant partager des informations et prendre des décisions ensemble sont de plus en plus communes. Cependant, Il existe peu de recherches sur ces comportements. Nous avons étudié deux équipes d'ingénierie provenant de cultures nationales différentes afin de comprendre les facteurs contextuels qui affectent les interactions entre les équipes et leurs comportements de partage d'information.
Information Seeking in a Global Context. The Creeping Influence of Economic Globalization & Corporatization: Neoliberal Discourse in Canadian Academic Libraries
Authors: Waugh Courtney
Published: August 2019

Strategic planning documents are "key sites to institutional discourse" and reflect the public face of the library. This research explores the extent to which Neoliberal discourse permeates the strategic plans of three Canadian academic libraries, and examines how they are responding to global economic and political pressures. Through content analysis, the tension between libraries as a public good versus libraries as commodity is examined. Within this context, the disconnect between librarian core values and changing institutional values is also explored.Les documents de planification stratégique sont des « sites clés pour tout discours institutionnel » et reflètent le visage public d’une bibliothèque. Cette recherche tente de prendre la mesure dans laquelle le discours néolibéral imprègne les documents de planification stratégique de trois bibliothèques universitaires canadiennes, et examine comment ces institutions répondent à la montée et à la diversification des pressions économiques et politiques mondiales. En utilisant l'analyse de contenu et un regard critique, cette recherche exploratoire examine la tension entre la conception de la bibliothèque comme bien public et sa conception comme produit de marchandisation.
IS THE MODULATION EFFECT OF MIDAZOLAM ON MORPHINE INDUCED ANTINOCICEPTION TIME DEPENDENT?
Authors: ARSLAN Seyfullah Oktay , ÖZKOÇAK TURAN İşıl
Published: August 2019

Aim: The aim
of this study was to investigate the effects of midazolam, morphine and
midazolam-morphine on nociception. Benzodiazepines are known to influence
opioid analgesia, and variations can be expected in the interaction between
benzodiazepines and opioids at different times of the day. Method: The
effects of midazolam, morphine, and midazolam-morphine combination on
nociception were evaluated with tail flick test in mice, with together the
time-dependent changes. Midazolam has not any antinociceptive effect and it
inhibited in a fashion dose-dependent the antinociceptive effect of morphine. Results: Control
group injected with saline displayed a significant diurnal rhythmicity in the
tail flick test significantly. Saline control group’s response latency at light
hour (at 16.00 h, P < 0.05) was
shorter than that at late dark hour (at 04.00 h) and early morning hour (at
08.00 h). Morphine injected animals had shorter response latencies in light
hours (at 12.00 and 16.00 h, P <
0.01) than at late dark hour (at 04.00 h) and early morning hour (at 08.00 h).
When midazolam was used in combination with morphine, the tail flick response
latencies became significant shorter clearly at every experiment times (P < 0.001), however this inhibition
was slightly lower at 04.00 h than the other hours.

Conclusion: Our
results indicate that midazolam antagonism on morphine antinociception have not
diurnal rhythmicity, however it may only slight decreased at late dark hours of
day.
Analisis Efisiensi Teknis Tempat Pelelangan Ikan (TPI) di Kabupaten Bantul
Authors: Pamungkas Handaka Ari , PF Aristi Dian , Wijayanto Dian
Published: August 2019

Penelitian ini bertujuan untuk menganalisis efisiensi teknis, serta sarana dan prasarana lima TPI di Kabupaten Bantul. Metode analisis data yang digunakan adalah analisis efisiensi DEA (Data Envelopment Analysis) dengan variabel input (jumlah karyawan TPI, jumlah nelayan, jumlah bakul, jumlah kapal, luas lantai lelang TPI, jumlah keranjang ikan dan jumlah timbangan) dan variabel output (jumlah produksi dalam satu tahun), analisis efisiensi metode produktivitas dan analisis sarana dan prasarana (Permen KP No.52A/KEPMEN-KP/2013). Hasil analisis efisiensi DEA menunjukkan bahwa lima TPI di Kabupaten Bantul memiliki skor efisiensi 100%, sedangkan hasil analisis efisiensi menggunakan metode produktivitas hanya TPI Depok yang memiliki efisiensi paling tinggi. Hasil analisis sarana dan prasarana menunjukkan bahwa di semua TPI belum tersedia penampungan pengolahan limbah, peringatan larangan masuk untuk kendaraan berasap dan binatang yang dapat mempengaruhi mutu hasil perikanan, serta peringatan larangan merokok, meludah, serta makan dan minum.
Pernikahan Kekerabatan Bani Kamsidin (Studi Kasus Pernikahan Endogami Di Jawa Timur Tahun 1974-2015 M)
Authors: Ama Siti Zya
Published: August 2019

Tradisi pernikahan kekerabatan Bani Kamsidin tidak umum terjadi jika dilihat dari sudut pandang ketentuan-ketentuan hukum dalam Islam dan norma serta adat yang berlaku di Indonesia pada umumnya. Keturunan Kamsidin yang sudah migran ke berbagai wilayah tetap memegang teguh tradisi pernikahan kekerabatan ini. Kemajuan pendidikan serta perkembangan zaman yang dialami keturunan Kamsidin tidak  menyurutkan pernikahan ini untuk tidak bertahan. Oleh karena itu penulis tertarik mengkaji lebih lanjut bagaimana sejarah pernikahan Bani Kamsidin ini terjadi meliputi asal usulnya beserta prosesnya, motif-motifnya, dan perkembangan pernikahan Bani Kamsidin di Jawa Timur dari tahun 1974 sampai 2015 M. Metode penelitian yang digunakan adalah metode penelitian sejarah  dengan melakukan beberapa tahap, yaitu tahap heuristik, verifikasi, interpretasi, dan historiografi. Hasil penulisan ini menunjukkan bahwa: pertama, pernikahan kekerabatan Bani Kamsidin bermula dari pesan Kamsidin kepada anak-anaknya untuk menikahkan anak-anaknya secara kekerabatan. Proses pernikahan kekerabatan Bani Kamsidin meliputi perjodohan, nyabek ocak, serpang, certacer, lamaran, ngalak sabek, akad nikah, resepsi pernikahan, ngirem, tongngebben, dan main ke ponduk. Kedua, perkembangan pernikahan kekerabatan Bani Kamsidin dapat diklasifikasikan ke dalam tiga periode, yaitu inti Bani Kamsidin, penyatuan keluarga, dan konflik. Ketiga, alasan Bani Kamsidin melakukan pernikahan kekerabatan adalah keyakinan agama, menjaga keturunan, dan menjaga keutuhan keluarga.

Kata Kunci: Pernikahan Kekerabatan, Bani Kamsidin.
Peranan Tuan Guru Haji Muhammad Kasyful Anwar dan Tuan Haji Setta dalam Mendirikan Pesantren Darussalam Martapura, Kabupaten Banjar, Kalimantan Selatan, 1924
Authors: Noor Yusliani , Sayyidati Rabini
Published: August 2019

Dalam kehidupan sosial-ekonomi masyarakat Banjar di Kalimantan Selatan mengenal pula kelompok pedagang dan pengusaha. Pedagang dan pengusaha yang sukses, dikenal dengan istilah; saudagar dan  juragan. Sebutan kehormatan untuk meraka adalah Tunji, singkatan dari Tuan Haji. Sejak tahun 1892 Pemerintah Kolonial Belanda telah mendirikan sekolah Kelas Dua untuk anak-anak rakyat biasa dan juga sekolah untuk anak-anak pegawai Pemerintah Kolonial. Motivasi memajukan pendidikan Islam di Martapura Kalimantan Selatan sejak 1900 semakin besar. Mengingat daerah lainnya telah mendirikan sekolah Islam. Lembaga pendidikan Islam tersebut, sebagai upaya mengimbangi intensifnya Pemerintah Kolonial Belanda dalam mendirikan sekolah-sekolah sekuler di Banjarmasin. Dalam rangka menahan arus pengaruh pendidikan barat yang dikelola Pemerintah Kolonial Belanda, Tuan Guru Muhammad Kasyful Anwar bekerjasama dengan Tuan Haji Setta, seorang saudagar Banjar mendirikan Pesantren Darussalam di Martapura, Kabupaten Banjar Kalimantan Selatan. Setidaknya, Pesantren Darussalam Martapura, Kalimantan Selatan menjadi bagian penting dalam membentuk karakter masyarakat Islam, yang memiliki ciri Ahlussunnah wal-jamaah, dengan tradisi ke NU-an.

Kata Kunci: Tuan Guru, Tuan Haji, Pesantren.
Hacia la corformación de las comunidades académicas y científicas en l a Universidad Autónoma de Manizales
Authors: Cardona Aguirre Alberto , Martinez Cecilia María , Peñaloza Tello Martha Lucía
Published: August 2019

A las puertas del año 2000 presenciamos día a día profundos cambios: cambian las economías de los países, se desintegran las ideologías, se modifican las creencias, cambia el entorno social.Colombia no escapa a la influencia de estos cambios mundiales y dado su escaso desarrollo, debe adecuar permanentemente sus estructuras de manera que le permitan una mayor competitividad: apertura económica, reformas educativas, reformas al sistema de salud, políticas de ciencia, tecnología y desarrollo, etc.