bluuebunny/crossref_metadata_2025 huggingface dataset:
New supersymmetric string theories from discrete theta angles
Authors: Montero Miguel , De Freitas Héctor Parra
Published: January 2023

Abstract

We describe three previously unnoticed components of the moduli space of minimally supersymmetric string theories in d ≥ 7, describing in some detail their spectrum and duality properties. We find a new component in nine and eight dimensions, and two additional ones in seven dimensions. These theories were originally discovered in a bottom-up classification of possible F/M-theory singularity freezing patterns in the K3 lattice, described in a companion paper. The 9d/8d component can be understood as F/M-theory on a twisted fibration of the Klein bottle over a circle, while the new seven-dimensional components are described as IIB on Bieberbach manifolds with a duality bundle and RR-NSNS backgrounds turned on. All the new components can be obtained from previously known theories by turning on certain discrete theta angles; however, the spectrum of massive objects is very different, and most strikingly, they feature an incomplete lattice of BPS strings, showing that string BPS completeness is not true in general even with sixteen supercharges. In all cases we find non-BPS representatives for each value of the charge, so the Completeness Principle is satisfied. We also analyze analogous theta angles in nonsupersymmetric string theories, and provide a detailed explanation of why the Type I discrete θ angle proposed in 1304.1551 is unphysical, using this to clarify certain non-perturbative phenomena in O8 planes.
An early-phase design process to enable long-term flexibility in assembly systems
Authors: Svensson Harari Natalia , Fundin Anders
Published: January 2023

Assembly systems require to be designed considering flexibility from a holistic perspective to produce the variety of current and future product generations. Reactive ad hoc changes after realizing both the product and assembly system designs require considerable effort and may even be impossible. A systematic collaborative approach that concurrently considers the early phases of product and assembly system development appears to be essential for working with long-term changes. To this end, a greater understanding of the working procedures and design activities concerning flexibility is required. In this paper, this is investigated based on a theoretical framework and a multiple case study at a world-leading manufacturer of heavy-duty vehicles. As a result, a developed early phase design process to enable long-term flexibility in assembly systems is presented. The theoretical implications provided and the findings are also relevant to those involved in the design process of flexible assembly systems.
Monitoring of ultra- and diafiltration processes by Kalman-filtered Raman measurements
Authors: Rolinger Laura , Hubbuch Jürgen , Rüdt Matthias
Published: January 2023

Monitoring the protein concentration and buffer composition during the Ultrafiltration/Diafiltration (UF/DF) step enables the further automation of biopharmaceutical production and supports Real-time Release Testing (RTRT). Previously, in-line Ultraviolet (UV) and Infrared (IR) measurements have been used to successfully monitor the protein concentration over a large range. The progress of the diafiltration step has been monitored with density measurements and Infrared Spectroscopy (IR). Raman spectroscopy is capable of measuring both the protein and excipient concentration while being more robust and suitable for production measurements in comparison to Infrared Spectroscopy (IR). Regardless of the spectroscopic sensor used, the low concentration of excipients poses a challenge for the sensors. By combining sensor measurements with a semi-mechanistic model through an Extended Kalman Filter (EKF), the sensitivity to determine the progress of the diafiltration can be improved. In this study, Raman measurements are combined with an EKF for three case studies. The advantages of Kalman-filtered Raman measurements for excipient monitoring are shown in comparison to density measurements. Furthermore, Raman measurements showed a higher measurement speed in comparison to Variable Pathlength (VP) UV measurement at the trade-off of a slightly worse prediction accuracy for the protein concentration. However, the Raman-based protein concentration measurements relied mostly on an increase in the background signal during the process and not on proteinaceous features, which could pose a challenge due to the potential influence of batch variability on the background signal. Overall, the combination of Raman spectroscopy and EKF is a promising tool for monitoring the UF/DF step and enables process automation by using adaptive process control.
Automated quantification of PET/CT skeletal tumor burden in prostate cancer using artificial intelligence: The PET index
Authors: Lindgren Belal Sarah , Larsson Måns , Holm Jorun , Buch-Olsen Karen Middelbo , Sörensen Jens , Bjartell Anders , Edenbrandt Lars , Trägårdh Elin
Published: January 2023

Purpose

Consistent assessment of bone metastases is crucial for patient management and clinical trials in prostate cancer (PCa). We aimed to develop a fully automated convolutional neural network (CNN)-based model for calculating PET/CT skeletal tumor burden in patients with PCa.

Methods

A total of 168 patients from three centers were divided into training, validation, and test groups. Manual annotations of skeletal lesions in [18F]fluoride PET/CT scans were used to train a CNN. The AI model was evaluated in 26 patients and compared to segmentations by physicians and to a SUV 15 threshold. PET index representing the percentage of skeletal volume taken up by lesions was estimated.

Results

There was no case in which all readers agreed on prevalence of lesions that the AI model failed to detect. PET index by the AI model correlated moderately strong to physician PET index (mean r = 0.69). Threshold PET index correlated fairly with physician PET index (mean r = 0.49). The sensitivity for lesion detection was 65–76% for AI, 68–91% for physicians, and 44–51% for threshold depending on which physician was considered reference.

Conclusion

It was possible to develop an AI-based model for automated assessment of PET/CT skeletal tumor burden. The model’s performance was superior to using a threshold and provides fully automated calculation of whole-body skeletal tumor burden. It could be further developed to apply to different radiotracers. Objective scan evaluation is a first step toward developing a PET/CT imaging biomarker for PCa skeletal metastases.
Antipsychotic drug-induced neutropenia: results from the AMSP drug surveillance program between 1993 and 2016
Authors: Glocker Catherine , Grohmann R. , Burkhardt G. , Seifert J. , Bleich S. , Held T. , Toto S. , Stübner S. , Schüle C.
Published: January 2023

Neutropenia and agranulocytosis (N&A) are relatively rare, but potentially fatal adverse drug reactions (ADR). This study presents cases of N&A related to one or more antipsychotic drugs (APDs) in psychiatric inpatients. Data on APD utilization and reports of N&A caused by APDs were analyzed by using data from an observational pharmacovigilance program in German-speaking countries—Arzneimittelsicherheit in der Psychiatrie (AMSP)—from 1993 to 2016. 333,175 psychiatric inpatients were treated with APDs for schizophrenia and other indications during the observation period. A total of 124 cases of APD-induced N&A were documented, 48 of which fulfilled the criteria for agranulocytosis, corresponding to a rate of 0.37, respectively, 0.14 in 1000 inpatients treated with APDs. Neutropenia was more often detected in women, whereas there was no difference regarding sex in cases of agranulocytosis. Clozapine had the highest relative risk for inducing N&A and was imputed alone as a probable cause of N&A in 60 cases (1.57‰ of all patients exposed). Perazine showed the second highest relative risk with 8 cases and an incidence 0.52‰, followed by quetiapine (15 cases resp. 0.23‰ of all patients exposed) and olanzapine (7 cases; 0.13‰ of all patients exposed). N&A most often occurred during the first 3 months of treatment. Overall N&A are severe and potentially fatal complications that can occur during treatment with APDs. The results from this study largely agree with the currently available literature, highlighting the positive effects of alertness and established appropriate monitoring.
CRISPR/Cas9-mediated knockin of IRES-tdTomato at Ins2 locus reveals no RFP-positive cells in mouse islets
Authors: Zhou Xueling , Fu Qi , Yang Tao , Sun Min
Published: January 2023

Using the CRISPR/Cas9 genomic editing technology, we constructed a transgenic mouse model to express specific fluorescent protein in pancreatic β cells, which harbor tdTomato exogenous gene downstream of the Ins2 promoter in C57BL/6 J mice. The Ins2-specific single-guide RNA-targeted exon2 was designed for the CRISPR/Cas9 system and Donor vector was constructed at the same time. Then Cas9, sgRNA, and Donor vector were microinjected in vitro into the mouse zygotes that were implanted into pseudo-pregnant mice. We obtained homozygotes through mating heterozygotes, and verified the knockin effect through genotype identification, in vivo imaging, and frozen section. Six F0 mice and stable inherited Ins2-IRES-tdTomato F1 were obtained. Genome sequencing results showed that the knockin group had no change in the Ins2 exon compared with the control group, while only the base sequence of tdTomato was added and no base mutation occurred. However, in vivo imaging and frozen section did not observe the expression of red fluorescent protein (RFP), and the protein expression of knockin gene tdTomato was negative. As a result, the expressions of tdTomato protein and fluorescence intensity were low and the detection threshold was not reached. In the CRISP/Cas9 technique, the exogenous fragment of IRES connection would affect the transcription level of the preceding gene, which in turn would lead to low-level expression of the downstream gene and affect the effect of gene insertion.
Selection tools and student diversity in health professions education: a multi-site study
Authors: Fikrat-Wevers S. , Stegers-Jager K. M. , Afonso P. M. , Koster A. S. , Van Gestel R. A. , Groenier M. , Ravesloot J. H. , Wouters A. , Van Den Broek W. W. , Woltman A. M.
Published: January 2023

Student diversity in health professions education (HPE) can be affected by selection procedures. Little is known about how different selection tools impact student diversity across programs using different combinations of traditional and broadened selection criteria. The present multi-site study examined the chances in selection of subgroups of applicants to HPE undergraduate programs with distinctive selection procedures, and their performance on corresponding selection tools. Probability of selection of subgroups (based on gender, migration background, prior education, parental education) of applicants (N = 1935) to five selection procedures of corresponding Dutch HPE undergraduate programs was estimated using multilevel logistic regression. Multilevel linear regression was used to analyze performance on four tools: prior-education grade point average (pe-GPA), biomedical knowledge test, curriculum-sampling test, and curriculum vitae (CV). First-generation Western immigrants and applicants with a foreign education background were significantly less likely to be selected than applicants without a migration background and with pre-university education. These effects did not vary across programs. More variability in effects was found between different selection tools. Compared to women, men performed significantly poorer on CVs, while they had higher scores on biomedical knowledge tests. Applicants with a non-Western migration background scored lower on curriculum-sampling tests. First-generation Western immigrants had lower CV-scores. First-generation university applicants had significantly lower pe-GPAs. There was a variety in effects for applicants with different alternative forms of prior education. For curriculum-sampling tests and CVs, effects varied across programs. Our findings highlight the need for continuous evaluation, identifying best practices within existing tools, and applying alternative tools.
Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation
Authors: Swiatlowska Pamela , Iskratsch Thomas
Published: January 2023

The local mechanical microenvironment impacts on the cell behavior. In the cardiovascular system, cells in both the heart and the vessels are exposed to continuous blood flow, blood pressure, stretching forces, and changing extracellular matrix stiffness. The force-induced signals travel all the way to the nucleus regulating epigenetic changes such as chromatin dynamics and gene expression. Mechanical cues are needed at the very early stage for a faultless embryological development, while later in life, aberrant mechanical signaling can lead to a range of pathologies, including diverse cardiovascular diseases. Hence, an investigation of force-generated epigenetic alteration at different time scales is needed to understand fully the phenotypic changes in disease onset and progression. That being so, cardiovascular mechano-epigenetics emerges as an attractive field of study. Given the rapid advances in this emergent field of research, this short review aims to provide an analysis of the state of knowledge of force-induced epigenetic changes in the cardiovascular field.
Contemporary Hermits: A Developmental Psychopathology Account of Extreme Social Withdrawal (Hikikomori) in Young People
Authors: Muris Peter , Ollendick Thomas H.
Published: January 2023

Although it is widely accepted that human beings have an ingrained ‘need to belong,’ there seem to be a substantial subset of young people who seclude themselves for most of the time at home and no longer engage in education or work, ultimately withdrawing from participation in society. In Japan, this phenomenon has been labeled as ‘hikikomori,’ but given its global presence it may be preferable to use the term ‘extreme social withdrawal’ (ESW). In this qualitative review, we provide a description and definition of ESW, provide figures on its prevalence, and discuss a number of associated concepts, including loneliness and “aloneliness,” school absenteeism and dropout, the ‘new’ developmental stage of adultolescence, and the labor force categories of freeter (‘freelance arbeiter’) and NEET (a young person not in employment, education, or training). The core of the paper is focused on the origins of ESW in young people and provides a narrative overview of relevant etiological factors, such as aberrant brain processes, unfavorable temperament, psychiatric conditions, adverse family processes including detrimental parenting, negative peer experiences, societal pressures, and excessive internet and digital media use, which are all placed within a comprehensive developmental psychopathology framework. We will close with a discussion of possible interventions for young people with ESW and formulate a guideline that describes (the temporal order of) various components that need to be included in such a treatment.
Climatic controls on the survival and loss of ancient types of barley on North Atlantic Islands
Authors: Martin Peter , Brown Terence A. , George Timothy S. , Gunnarson Björn , Loader Neil J. , Ross Paul , Wishart John , Wilson Rob
Published: January 2023

For ancient types of barley at sites in the Scottish Isles, Faroes, and Iceland, we calculated minimum temperature requirements for grain production (grain production threshold, GPT) as accumulated degree days over the cropping season. Site suitability for barley from AD 1200 to 2000 was investigated by comparing these thresholds with reconstructions of annual cropping season degree days (CSDD) using temperature and tree-ring data. In Iceland, between AD 1200 and 1500, reconstructed CSDD were more favorable in the southwest (Reykjavik), with fewer years below the GPT, than in the North, East and West, but there were two periods (1340–1389 and 1426–1475) with low average CSDD and several years below the GPT which possibly influenced the abandonment of barley cultivation around this time. Reconstructed CSDD for the Faroes (Tórshavn) had only one year below the GPT, but 15 periods of four or more consecutive years with low CSDD which would have challenged barley cultivation, especially in the thirteenth century. Reconstructed CSDD were highest for the Scottish Isles, allowing a more prominent role of barley in the farming system and economy. Nevertheless, years with poor harvests or famines were common and about half were associated with low CSDD, resulting in a significant temperature link but also demonstrating the important contribution of other factors. Despite frequent unfavorable years in both the Faroes and Scottish Isles, resilient production systems, well-adapted barley strains and socio-economic factors allowed barley cultivation to continue, and some ancient types to survive to the present day.
Cutting through the value chain: the long-run effects of decoupling the East from the West
Authors: Felbermayr Gabriel , Mahlkow Hendrik , Sandkamp Alexander
Published: January 2023

With ever-increasing political tensions between China and Russia on one side and the EU and the US on the other, it only seems a matter of time until protectionist policies cause a decoupling of global value chains. This paper uses a computable general equilibrium trade model calibrated with the latest version of the GTAP database to simulate the effect of such a decoupling–implemented by doubling non-tariff barriers–between the two blocks on trade and welfare. Imposing import barriers almost completely eliminates bilateral imports. In addition, changes in price levels lead to higher imports and lower exports of the imposing country group from and to the rest of the world. The targeted country group increases exports to the rest of the world and reduces imports. Welfare falls in all countries involved, suggesting that governments should strive to cooperate rather than turn away from each other. By imposing a trade war on Russia, the political West could inflict severe damage on the Russian economy because of the latter’s smaller relative economic size.
Modelling of the Torsional Simple Shear Test with Randomized Tresca Model Properties in Midas GTS NX
Authors: Ahmad Majd , Ray Richard
Published: January 2023

The dynamic properties of soil obtained from the torsional simple shear test (TOSS) are assumed to be uniform throughout the specimen. For some exceptional soils, this may hold true, but for the most majority of soils that we examine, it is obviously not the case, and this level of non-uniformity depends on the conditions in which the soil was formed. In this paper, we discuss a method of modelling inherently non-uniform soil specimens by representing them with elements that have an elasto-plastic simple Tresca material model with different properties (Elastic young modulus and yield stresses). The combination of properties that can simulate the nonlinear behaviour of the soil is found and calibrated using a model of the TOSS test built in the finite element software Midas GTS NX. Furthermore, the influence of rigid inclusions in the soil is studied and the results show an increase in stiffness with the increasing percentage of inclusion in the soil.
Non-connected Lie groups, twisted equivariant bundles and coverings
Authors: Barajas G. , García-Prada O. , Gothen P. B. , Riera I. Mundet i
Published: January 2023

Let $$\Gamma $$
Γ
be a finite group acting on a Lie group G. We consider a class of group extensions $$1 \rightarrow G \rightarrow \hat{G} \rightarrow \Gamma \rightarrow 1$$

1
→
G
→

G
^

→
Γ
→
1

defined by this action and a 2-cocycle of $$\Gamma $$
Γ
with values in the centre of G. We establish and study a correspondence between $$\hat{G}$$

G
^

-bundles on a manifold and twisted $$\Gamma $$
Γ
-equivariant bundles with structure group G on a suitable Galois $$\Gamma $$
Γ
-covering of the manifold. We also describe this correspondence in terms of non-abelian cohomology. Our results apply, in particular, to the case of a compact or reductive complex Lie group $$\hat{G}$$

G
^

, since such a group is always isomorphic to an extension as above, where G is the connected component of the identity and $$\Gamma $$
Γ
is the group of connected components of $$\hat{G}$$

G
^

.
Strengths and weaknesses of pneumococcal conjugate vaccines
Authors: Micoli Francesca , Romano Maria Rosaria , Carboni Filippo , Adamo Roberto , Berti Francesco
Published: January 2023

Multivalent vaccines addressing an increasing number of Streptococcus pneumoniae types (7-, 10-, 13-, 15-, 20-valent) have been licensed over the last 22 years. The use of polysaccharide-protein conjugate vaccines has been pivotal in reducing the incidence of invasive pneumococcal disease despite the emergence of non-vaccine serotypes. Notwithstanding its undoubtable success, some weaknesses have called for continuous improvement of pneumococcal vaccination. For instance, despite their inclusion in pneumococcal conjugate vaccines, there are challenges associated with some serotypes. In particular, Streptococcus pneumoniae type 3 remains a major cause of invasive pneumococcal disease in several countries.

Here a deep revision of the strengths and weaknesses of the licensed pneumococcal conjugate vaccines and other vaccine candidates currently in clinical development is reported.
Characterization of a sex-determining locus and development of early molecular assays in Telfairia occidentalisHook. F., a dioecious cucurbit
Authors: Metry Adrian , Adeyemo Oyenike Arike , Grünig Sandra , Parisod Christian
Published: January 2023

Although there exist over 7000 crop species, only a few are commercially valuable and grown on a large scale in monocultures worldwide. However, underutilised crops (also called orphan crops) have significant potential for food security and Telfairia occidentalis Hook. F. (Cucurbitaceae) is one such orphan crop grown in West Africa for its nutritious leaves, oil and protein-rich seeds. In this dioecious crop, farmers like to eliminate male plants and keep mostly females to increase their yield. However, they face the challenge of determining sex due to limited morphological differences between females and males before flowering. This study used double digested restriction site-associated DNA sequencing data (ddRADseq) to examine the genetic diversity within and among landraces of T. occidentalis, identify common sex-determining loci, and establish reliable assays to characterize the sex of immature plants in the vegetative state. To differentiate males from females of T. occidentalis, two molecular assays were thereupon developed based on polymerase chain reaction (PCR) to genotype sex-specific sequence variation either through restriction by Mfe1 or the direct use of sex-specific primers. Both assays require standard laboratory conditions to reach a certainty of 94.3% for females and 95.7% for males from the studied samples. With the inclusion of additional landraces, medium to largescale farms growing T. occidentalis as a crop can readily benefit from an early determination of the sex of plants.
Incidence of premature battery depletion in subcutaneous cardioverter-defibrillator patients: insights from a multicenter registry
Authors: Lüker Jakob , Strik Marc , Andrade Jason G. , Raymond-Paquin Alexandre , Elrefai Mohamed Hassan , Roberts Paul R. , Pérez Óscar Cano , Kron Jordana , Koneru Jayanthi , Franqui-Rivera Hilton , Sultan Arian , Ernst Angela , Schmitt Jörn , Pott Alexander , Veltmann Christian , Srinivasan Neil T , Collinson Jason , van Stipdonk Antonius M. W. , Linz Dominik , Fluschnik Nina , Tönnis Tobias , Haeberlin Andreas , Ploux Sylvain , Steven Daniel
Published: January 2023

Background

The subcutaneous ICD established its role in the prevention of sudden cardiac death in recent years. The occurrence of premature battery depletion in a large subset of potentially affected devices has been a cause of concern. The incidence of premature battery depletion has not been studied systematically beyond manufacturer-reported data.

Methods

Retrospective data and the most recent follow-up data on S-ICD devices from fourteen centers in Europe, the US, and Canada was studied. The incidence of generator removal or failure was reported to investigate the incidence of premature S-ICD battery depletion, defined as battery failure within 60 months or less.

Results

Data from 1054 devices was analyzed. Premature battery depletion occurred in 3.5% of potentially affected devices over an observation period of 49 months.

Conclusions

The incidence of premature battery depletion of S-ICD potentially affected by a battery advisory was around 3.5% after 4 years in this study. Premature depletion occurred exclusively in devices under advisory. This is in line with the most recently published reports from the manufacturer.

Trial registration

ClinicalTrials.gov Identifier: NCT04767516.
The impact of a stress management intervention including cultural components on stress biomarker levels and mental health indicators among indigenous women
Authors: Aker Amira , Serghides Lena , Cotnam Jasmine , Jackson Randy , Robinson Margaret , Gauvin Holly , Mushquash Christopher , Gesink Dionne , Amirault Marni , Benoit Anita C.
Published: January 2023

We examined the effectiveness of a 26-week culture-inclusive intervention on reducing salivary stress biomarker levels, and perceived stress, depressive, and post-traumatic stress disorder (PTSD) symptoms measured using scales in 53 Indigenous women in Ontario, Canada. Statistical analyses compared the average biomarker levels, and the area under the curve (AUC) of biomarkers. Differences in biomarkers and mental health scale scores pre- and post-intervention were compared using mixed models with a random intercept. Interaction terms were included between the intervention and age, education, disability, and HIV status, individually, to test for sub-group differences. Cortisol AUC post-intervention was decreased compared to pre-intervention (β -1.29 µg/dL; 95%CI -2.35, -0.23). There was a slight decrease in perceived stress levels (aOR: -2.80; 95%CI -5.09, -0.50). The associations were stronger among women of younger age, higher education, and no disabilities. These interventions can be effective, but future interventions should target Indigenous population sub-groups to address individual needs.
A fault detection method based on partition of unity and kernel approximation
Authors: Mirzaei Davoud , Soodbakhsh Navid
Published: January 2023

In this paper, we present a scattered data approximation method for detecting and approximating the discontinuities of a bivariate function and its gradient. The new algorithm is based on partition of unity, polyharmonic kernel interpolation, and principal component analysis. Localized polyharmonic interpolation in partition of unity setting is applied for detecting a set of fault points on or close to discontinuity curves. Then a combination of partition of unity and principal component regression is used to thinning the detected points by moving them approximately on the fault curves. Finally, an ordered subset of these narrowed points is extracted and a parametric spline interpolation is applied to reconstruct the fault curves. A selection of numerical examples with different behaviors and an application for solving scalar conservation law equations illustrate the performance of the algorithm.
Pituitary enlargement in patients with cerebrospinal fluid drainage due to ventricular shunt insertion: know the condition and do not mistake for adenoma
Authors: Grzywotz Agnieszka , Li Yan , Unger Nicole , Kiewert Cordula , Chmielewski Witold X. , Sure Ulrich , Uerschels Anne , Wrede Karsten , Kreitschmann-Andermahr Ilonka
Published: January 2023

Objective

Childhood hydrocephalus patients treated by ventriculo-peritoneal (v.-p.) shunting are sometimes referred years after this therapy for evaluation of suspicious pituitary enlargement. Since pituitary size has been shown to depend on cerebrospinal fluid (CSF) pressure, we assume this phenomenon to be caused by shunt overdrainage. Therefore, we studied pituitary size and morphology in shunted hydrocephalus patients with radiological signs of high CSF drainage.

Patients and methods

Retrospective study of pituitary size and morphology in 15 shunted patients with non-tumoral hydrocephalus and 7 shunted hydrocephalus patients due to childhood brain tumor compared to a population mean. In five brain tumor patients also pre- and postsurgical comparisons were performed.

Results

Pituitary mid-sagittal size and pituitary volume were significantly higher in both hydrocephalus groups, compared to the population mean (midsagittal size t = 5.91; p < 0.001; pituitary volume, t = 3.03; p = 0.006). In patients available for pre- and postoperative comparison, there was also a significant increase in pituitary size and volume postoperatively (mean preoperative midsagittal height 2.54 ± 1.0 mm vs. 6.6 ± 0.7 mm post-surgery; mean pre-operative pituitary volume 120.5 ± 69.2 mm3 vs. 368.9 ± 57.9 mm3 post-surgery).

Conclusion

Our results confirmed a significant increase in pituitary size and volume, mimicking pituitary pathology, after v.-p. shunt insertion. This phenomenon can be explained by the Monro–Kellie doctrine, stating that intracranial depletion of CSF—as caused by v.p. shunting—leads to compensatory intracranial hyperemia, especially in the venous system, with the consequence of engorged venous sinuses, most likely responsible for enlargement of the pituitary gland.
Democracy Does Improve Health
Authors: Oyèkọ́lá Ọláyínká
Published: January 2023

In this paper, we study the extent to which the spread of democracy affects country-level health outcomes in 115 countries, between 1960 and 2015. To do this, we use both the level and change measures of democracy in our regressions, concentrating on within-country variations. Our finding is that a one standard deviation increase of 0.35 in the level of democracy is associated with a 0.11 standard deviation increase in life expectancy, even after accounting for various country and time features. This corresponds to an increase in life expectancy of around 5 years for a country initially, with a mean life expectancy of 54 years. However, we do not find the change measure of democracy to be consistently influential. These results are robust to employing alternative model specifications, to using different subsamples of the data, and to alternative estimation techniques. We also find that these critical effects are retained when using other measures of health status. In particular, we observe that as the level of democracy rises, each of infant mortality, child mortality, and crude death decreases. We, therefore, conclude that the material role of democratic institutions in fostering population health is of first-order relevance.
Some notes on The Palgrave Handbook of Russian Thought
Authors: Obolevitch Teresa
Published: January 2023

These are my comments on The Palgrave Handbook of Russian Thought at the ASEEES convention (Chicago, November 2022).
Sulfidation of Supported Ni, Mo and NiMo Catalysts Studied by In Situ XAFS
Authors: Gajdek Dorotea , Jensen Lucy Idowu Ajakaiye , Briois Valérie , Hulteberg Christian , Merte Lindsay R. , Blomberg Sara
Published: January 2023

Active sites in Mo-based hydrotreating catalysts are produced by sulfidation. To achieve insights that may enable optimization of the catalysts, this process should be studied in situ. Herein we present a comparative XAFS study where the in situ sulfidation of Mo/δ-Al2O3 and Ni/δ-Al2O3 is compared to that of δ-Al2O3 supported NiMo catalysts with different NiMo ratios. The study also covers the comparison of sulfidation of Ni and Mo using different oxide supports as well as the sulfidation conditions applied in the reactor. The XAFS spectra confirms the oxide phase for all catalysts at the beginning of the sulfidation reaction and their conversion to a sulfidized phase is followed with in situ measurements. Furthermore, it is found that the monometallic catalysts are less readily sulfidized than bimetallic ones, indicating the importance of Ni-Mo interactions for catalyst activation. Mo K-edge XAFS spectra did not show any difference related to the support of the catalyst or the pressure applied during the reaction. Ni K-edge XAFS spectra, however, show a more complete sulfidation of the Ni species in the catalyst when SiO2 is used as a support as compared to the Al2O3. Nevertheless, it is believed that stronger interactions with Al2O3 support prevent sintering of the catalyst which leads to its stabilization. The results contribute to a better understanding of how different parameters affect the formation of the active phase of the NiMo catalysts used in the production of biofuel.
Of Marriage and Mathematics: Inferentialism and Social Ontology
Authors: Collin James Henry
Published: January 2023

The semantic inferentialist account of the social institution of semantic meaning can be naturally extended to account for social ontology. I argue here that semantic inferentialism provides a framework within which mathematical ontology can be understood as social ontology, and mathematical facts as socially instituted facts. I argue further that the semantic inferentialist framework provides resources to underpin at least some aspects of the objectivity of mathematics, even when the truth of mathematical claims is understood as socially instituted.
Accommodating heterogeneity: the interaction of instructional scaffolding with student preconditions in the learning of hypothesis-based reasoning
Authors: Grimm Hanna , Edelsbrunner Peter A. , Möller Kornelia
Published: January 2023

Hypothesis-based reasoning with conditionals is a skill that is required for engaging in integral activities of modern elementary school science-curricula. The teaching of this skill at this early stage of education, however, is demanding, particularly in whole school classes in which it is difficult to adapt teaching to children’s individual needs. We examine whether a scaffold that is static yet tailored to the context, in which the teacher explicitly models the reasoning process, manages to meet students’ individual cognitive preconditions for learning this skill. Within an inquiry-based learning setting, N = 143 third-graders underwent either an experimental condition in which they received the explicit scaffold, or a control condition in which they did not receive this specific scaffold. Employing a latent transition analysis and a general additive model, it is examined how the additional scaffold interacted with students’ prior knowledge, inhibition ability, and logical reasoning judged by their own teachers. It is found that the additional scaffolds managed to meet the needs of students with little prior knowledge; under the control condition, students with little prior knowledge showed decreased learning achievement, whereas under the experimental condition, students with differing prior knowledge learned to comparable extent and on a higher level. The scaffolds also almost fully diminished a disadvantage for students with lower teacher-judged logical reasoning, and supported students with high inhibition ability in mastering the most difficult aspect of reasoning based on irrelevant evidence. Implications for science education are discussed.
The Relationship of COVID-19 Vaccination with Mortality Among 86,732 Hospitalized Patients: Subpopulations, Patient Factors, and Changes over Time
Authors: Baker Timothy B. , Bolt Daniel M. , Smith Stevens S. , Piasecki Thomas M. , Conner Karen L. , Bernstein Steven L. , Hayes-Birchler Todd , Theobald Wendy E. , Fiore Michael C.
Published: January 2023

Information on COVID-19 vaccination effects on mortality among patients hospitalized with COVID-19 could inform vaccination outreach efforts and increase understanding of patient risk.

Determine the associations of vaccination status with mortality in adult patients hospitalized with COVID-19.

This retrospective cohort study assessed the characteristics and mortality rates of adult patients hospitalized with COVID-19 across 21 healthcare systems in the USA from January 1, 2021, to January 31, 2022.

Adult patients admitted to participating hospitals who had COVID-19 diagnoses and/or positive PCR tests and completed their hospital stay via discharge or death.

In-hospital mortality vs. discharge (outcome) and patient age, sex, race, ethnicity, BMI, insurance status, comorbidities, and vaccination status extracted from the electronic health record (EHR).

Of 86,732 adult patients hospitalized with COVID-19, 45,082 (52%) were female, mean age was 60 years, 20,800 (24%) were Black, and 22,792 (26.3%) had one or more COVID-19 vaccinations. Statistically adjusted mortality rates for unvaccinated and vaccinated patients were 8.3% (95% CI, 8.1–8.5) and 5.1% (95% CI, 4.8–5.4) respectively (7.9% vs. 4.5% with no immune compromise). Vaccination was associated with especially large reductions in mortality for obese (OR = 0.67; 95% CI 0.56–0.80) and severely obese (OR = 0.52; 95% CI, 0.41–0.67) patients and for older patients (OR = 0.99; 95% CI, 0.98–0.99). Mortality likelihood was higher later in the study period (August 2021–January 31, 2022) than earlier (January 1, 2021–July 30, 2021) (OR = 1.10; 95% CI = 1.04–1.17) and increased significantly for vaccinated patients from 4.6% (95% CI, 3.9–5.2%) to 6.5% (95% CI, 6.2–6.9%).

Patients vaccinated for COVID-19 had reduced mortality, especially for obese/severely obese and older individuals. Vaccination’s protective effect against mortality declined over time and hospitalized obese and older individuals may derive especially great benefit from prior vaccination against SARS-CoV-2.
Minimizing responsibility in the aggressive dynamics of bullying and its impact on other strategies of moral disengagement: a longitudinal study
Authors: Falla Daniel , Ortega-Ruiz Rosario , Romera Eva M.
Published: January 2023

Not assuming responsibility, or minimizing it, after committing an offence is one of the four moral disengagement strategies linked to the phenomenon of bullying described by the Social Cognitive Theory. However, to date, there has been no research into the role of the agent’s locus in this process and the mediating effect of bullying perpetration in the possible evolutionary sequencing of moral disengagement strategies. This study addresses both of these goals. A total of 1107 schoolchildren (54.7% girls; Mage = 14.49; SD = 0.789) were surveyed in a longitudinal study at three time points spaced six months apart. The results indicated that minimizing responsibility directly predicts both cognitive restructuring and distortion of consequences. They also confirmed that aggressive perpetration in bullying has a mediating effect on all three strategies. Nevertheless, this sequential dynamic does not include dehumanization, which was not directly linked to minimizing responsibility and was mediated by the perpetration of aggression in bullying. We discuss the extent to which minimizing responsibility is the first step in a temporal sequence of moral disengagement mechanisms that help maintain the aggressive dynamic in bullying, so that it stimulates the other mechanisms and incorporates the locus of the aggressive agent. These findings allow us to advance in our understanding of the ethical dimension (sensitivity and moral criteria) implicit in the phenomenon of unjustified aggressiveness known as bullying.
DMP-Based Reactive Robot-to-Human Handover in Perturbed Scenarios
Authors: Iori Francesco , Perovic Gojko , Cini Francesca , Mazzeo Angela , Falotico Egidio , Controzzi Marco
Published: January 2023

While seemingly simple, handover requires joint coordinate efforts from both partners, commonly in dynamic collaborative scenarios. Practically, humans are able to adapt and react to their partner’s movement to ensure seamless interaction against perturbations or interruptions. However, literature on robotic handover usually considers straightforward scenarios. We propose an online trajectory generation method based on Dynamic Movement Primitives to enable reactive robot behavior in perturbed scenarios. Thus, the robot is able to adapt to human motion (stopping should the handover be interrupted while persisting through minor disturbances on the partner’s trajectory). Qualitative analysis is conducted to demonstrate the capability of the proposed controller with different parameter settings and against a non-reactive implementation. This analysis shows that controllers with reactive parameter settings produce robot trajectories that can be deemed as more coordinated under perturbation. Additionally, a randomized trial with participants is conducted to validate the approach by assessing the subject perception through a questionnaire while measuring task completion and robot idle time. Our method has been shown to significantly increase the subjective perception of the interaction with no statistically significant deterioration in task performance metrics under one of the two sets of parameters analyzed. This paper represents a first step towards the introduction of reactive controllers in handover tasks that explicitly consider perturbations and interruptions.
A simulation-based optimization approach for designing transit networks
Authors: Nnene Obiora A. , Joubert Johan W. , Zuidgeest Mark H. P.
Published: January 2023

Public transport network design deals with finding efficient network solution(s) from a set of alternatives that best satisfies the often-conflicting objectives of stakeholders like passengers and operators. This work presents a simulation-based optimization (SBO) model for designing public transport networks. The work’s novelty is in developing such a network design model that fully accounts for the stochastic behavior of commuters on the transit network. The SBO discipline solves decision-based problems like the transit network design problem (TNDP) by combining simulation and optimization models. The proposed model integrates a disaggregated activity-based travel demand simulation with a multi-objective network optimization algorithm. Trip-based travel demand models are commonly used to represent traveler behavior in the literature. The approach limits its ability to accommodate the stochastic realities of traveler behavior in a transit network design solution. Using activity-based simulation instead makes it possible to account for a more realistic traveler behavior, especially real-time decisions made in response to changing network dynamics which ultimately affect the distribution of demand over time on the network. The proposed model is applied to the improved design of the integrated public transport network in the City of Cape Town, South Africa. The results show SBO can design efficient network solutions that reflect the objectives of network stakeholders.
The Impact of the Social Mood on the Italian Sovereign Debt Market: A Twitter Perspective
Authors: Carnazza Giovanni
Published: January 2023

By analysing the relationship between a new experimental daily index based on Twitter data (the Istat’s Social Mood on Economy Index—SMoEI) and the structure of Italian (and Spanish) sovereign interest rates, our work sheds new light on the great significance of the interconnections between economic sentiment and the Italian sovereign bond market. A placebo test performed on Spain introduces a possible extension of this linkage to the European market, highlighting the deep integration of financial markets within the European Monetary Union. Within a VAR and VECM framework with daily frequency data (2016–2022), we show that public shaping mechanisms play a role in the cost of debt financing. Our analysis emphasises the importance of economic sentiment when it comes to financial markets, putting the role of macroeconomic fundamentals in a different light. This result should be interpreted with caution, as updates to fundamentals can be affected by a time lag. In any case, recognising the importance of this index has at least two implications: on the one side, the SMoEI could represent a more responsive indicator for predicting investor sentiment; on the other side, media channels—as well as the European and national institutions—should gain relevance for their potential impact on collective sentiment, encouraging the importance of economic education and non-alarmist communication.
Autonomous demand and technical change: exploring the Kaldor–Verdoorn law on a global level
Authors: Deleidi Matteo , Fontanari Claudia , Gahn Santiago José
Published: January 2023

This paper aims to explain labour productivity through the lens of a Kaldorian perspective. To assess the relationship between output, demand, capital accumulation, and labour productivity, we apply Panel Structural Vector Autoregressive (P-SVAR) modelling to a dataset of 52 countries observed over a long-time span as provided by the Penn World Table. Findings validate the Kaldorian perspective and show that demand shocks—measured by government expenditures and exports—produce positive and persistent effects on labour productivity. Findings are confirmed even when the full sample is broken down to consider developed and developing countries separately.
Development of Rectangular Vibration Isolators with Double Core Systems for Structures
Authors: Altalabani Diyar , Hejazi Farzad
Published: January 2023

One of the best techniques for isolating structures from the ground is the seismic isolation technique. Nowadays, square and circular base isolators are the most frequently employed shapes. Nevertheless, these configurations are not applicable for the wall-like structures; since the applied loads are not distributed in a way that provides a uniform support condition along the shear walls. To address this issue, attempts were made to develop novel rectangular isolators with lead/rubber cores. A total of five large-scale rectangular isolators were experimentally tested and subsequently subjected to finite element analysis. A rectangular seismic isolator having double lead cores was proposed to improve its effectiveness. Exposure to lead-containing materials has been shown to have poisonous effects on both the human health and environment. To avoid this, an isolator having double rubber cores was developed. Moreover, the rubber cores are wrapped with one layer of CFRP sheet and stainless steel tube to enhance the damping ratio of the rectangular isolators. Thereafter, the novel isolators were implemented in a 10-storey tunnel-form building using nonlinear dynamic analyses. The seismic performance of the buildings was then studied by conducting Incremental Dynamic Analyses. The experimental outcomes demonstrated that confining the rubber cores by stainless steel tube and CFRP sheet increased the energy absorption along the length of the isolators by 15 and 7%, respectively. Moreover, the damping ratios of the rectangular isolator with double lead cores have also increased by 36 and 47% along its length and width, respectively.