bluuebunny/crossref_metadata_2025 huggingface dataset:
CD39 inhibits increased inflammation and promotes resolution of gout
Authors: Luo chengyu , Liu Xingyue , Shao  , Liu  , Gao Jie , Tao Jinhui
Published: May 2023

Background
Gout is a self-limiting inflammatory arthritis induced by the formation of urate crystals due to hyperuricemia. Recent studies have shown that the pathogenesis of gout involves the participation of extracellular ATP, and the synergistic effect of MSU and extracellular ATP can cause gout. CD39 is an ATP hydrolase that is distributed on the surface of macrophages and almost all other immune cells, and it can inhibit inflammation caused by ATP. This suggests that CD39 may inhibit the aggravation of gout inflammation and participate in the remission mechanism of gout.
Methods
The expression of CD39 mRNA in PBMCs from gout patients, PBMCS from gout model rats and THP-1 cells stimulated by MSU were detected and analyzed. CD39 knockdown was carried out by lentivirus in a monosodium urate (MSU) induced rat model, and CD39 inhibitor was used in MSU induced mouse model. After CD39 was blocked, the activation level of NLRP3 inflammasome and the incidence of gout were observed.
Results
The results showed that the deletion of CD39 aggravated MSU-induced gouty arthritis and delayed the remission of gout. Furthermore, it promoted the activation of the NLRP3 inflammasome signaling pathway and the release of IL-1βin macrophages.
Conclusions
Our results confirm that CD39 is elevated in the gout inflammatory environment, and its presence inhibits the aggravation of inflammation and promotes the resolution of gout.
Biomarkers in endurance exercise - Individualized regulation and predictive value
Authors: Hacker Sebastian , Keck Johannes , Reichel Thomas , Eder Klaus , Ringseis Robert , Krüger Karsten , Krüger Britta
Published: May 2023

Objectives The high inter-individual variability of exercise response complicates the efficient use of blood-based biomarkers in sports. To address the problem, a useful algorithm to characterize the individual regulation and predictive value of different candidate markers will be developed.Methods Forty-nine participants completed two identical exercise trials. Blood samples were collected before, immediately after, 3 hours after and 24 hours after completion of exercise. Plasma concentrations of interleukin (IL-) 1RA, IL-8, IL-15, IL-10, CK, CRP, LDH, cortisol and thiobarbituric acid reactive substances (TBARS) were measured. Individualized regulation was analyzed using k-means clustering and a Group Assignment Quality Score (GAQ). Regression trees with a bootstrapped-aggregated approach were used to assess the predictive qualities of the markers.Results For most of the markers studied, a distinction can be made between individuals who show a stronger or weaker response to a particular endurance training program. The regulation for IL-10, IL-6, IL-8 and CK exhibited a high degree of stability within the individuals. Regarding the predictive power of the markers, for all dependent variables, the most accurate predictions were obtained for cortisol and IL-8 based on the baseline value. For CK, a good prediction of recovery of maximal strength and subjective feeling of exhaustion can be made. For IL-1RA and TBARS, especially their re-regulation can be predicted if the baseline level is known.Perspectives Focusing individual variations in biomarker responses, our results suggest the combined use of IL-6, IL-8, IL-10, and CK for the personalized management of stress and recovery cycles following endurance exercise.
NOD-like-receptor signaling pathway mediates inflammation and triggers cerebral injury in cerebral venous thrombosis
Authors: Zhou Yifan , Jiang Huimin , Wei Huimin , Xiao Xuechun , Liu Lu , Zhou Chenxia , Ma Wei , Ji Xunming , Zhou Chen
Published: May 2023

Background
Cerebral venous thrombosis (CVT) is a special type of stroke with an increasing incidence. However, the pathophysiological mechanisms remain elusive, which hinders a comprehensive understanding of CVT. We used a CVT model in rats to elucidate the mechanism of neurological damage.
Methods
We constructed a CVT model to examine neurological function and performed neuroimaging. RNA-Seq and biological information technology were utilized to analyze the transcriptome features of the Sham, middle cerebral artery occlusion (MCAO), and CVT groups, subsequently selecting significantly upregulated signaling pathways in the CVT rat brain. The activation of signaling pathways and immune cells in CVT was confirmed through flow cytometry (FC), real-time quantitative polymerase chain reaction (qPCR), and immunofluorescence staining (IF).
Results
Twenty-four hours after CVT establishment, rats exhibited significant Magnetic resonance imaging (MRI)-T2 hyperintensity and neurological impairment compared to sham rats. Transcriptome profiling showed that the inflammatory response was a significant and specific characteristic of the CVT group compared with the sham and MCAO groups. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of differentially expressed genes (DEGs) indicated that the DEGs were mainly enriched in the gene set of inflammation-related responses. Single-sample gene set enrichment analysis (ssGSEA) also suggested that the immune inflammatory response score was increased significantly. Furthermore, Immune-AI mouse revealed that microglia were the most significantly elevated immune inflammatory cells after CVT. GSEA indicated that the nucleotide-binding oligomerization domain (NOD)-like-receptor signaling pathway was significantly upregulated compared to other inflammatory signaling pathways, and then, key driver analysis (KDA) of DEGs in the NOD-like-receptor signaling pathway revealed that Nod-2 and other genes were the core genes. Importantly, inhibiting the NOD-like-receptor signaling pathway in CVT rats resulted in neurological function improvement and infarct size reduction.
Conclusions
The microglia-mediated inflammatory response and NOD-like-receptor signaling pathway activation are significant pathological changes in brain injury after CVT. This study may enhance comprehension of the pathological mechanisms underlying CVT and provide novel insights for further investigation into injuries in CVT.
Cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma compared to population norms and healthy controls: an exploratory study
Authors: Gates Priscilla , Dhillon Haryana. M , Krishnasamy Mei , Wilson Carlene , Gough Karla
Published: May 2023

Purpose
Cancer-related cognitive impairment is an adverse consequence of cancer and its treatment. There has been little research with patients with aggressive lymphoma. We describe self-reported cognitive function and neuropsychological performance data in patients with lymphoma and compare them with healthy controls and population norms. Associations between patients’ neuropsychological performance, cognitive function and distress are also examined.
Methods
Secondary analysis of data from a longitudinal feasibility study of 30 participants with newly diagnosed aggressive lymphoma and 72 healthy controls was performed. Participants completed validated self-report measures and neuropsychological tests before, and 6–8 weeks after chemotherapy. Healthy controls completed the FACT-Cog and neuropsychological tests at enrolment and six-months later. Mixed models were used to analyse FACT-Cog and neuropsychological test scores. Kendall’s Tau provided a measure of association between global deficit and data from other measures.
Results
Patients and healthy controls were well matched on demographics. Differences between the two groups’ neuropsychological test scores were mostly large-sized; patients’ performance was poorer both before and after chemotherapy (most p < 0.001). The same pattern was observed for impact of perceived cognitive impairment on quality-of-life (both p < 0.001), but not perceived cognitive impairment or abilities (all p > 0.10). Associations between neuropsychological performance, self-reported cognitive function and distress, were trivial to small-sized (all p > 0.10).
Conclusion
For many patients with aggressive lymphoma, impaired neuropsychological test performance and impact of perceived impairments on quality-of-life precede chemotherapy and are sustained 6–8 weeks after chemotherapy. Our data support the need for further longitudinal studies with this population to better understand targets for interventions to address cognitive impairment.
The effect of fatigue on postural control in individuals with multiple sclerosis: A systematic review
Authors: Sedaghati Parisa , Alghosi Mohammad , Hosseini Freshteh
Published: May 2023

Background: Fatigue is the most disabling ‎symptom for individuals with multiple ‎sclerosis which can significantly affect postural control by impairing the ability of the central nervous system to modulate sensory inputs and coordinate motor responses. This systematic review aimed to accumulate the existing evidence. This systematic review aimed to investigate the effect of ‎fatigue on postural control in individuals with multiple ‎sclerosis.‎
Methods: This systematic review was performed in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement and registered in PROSPERO with ID CRD42022376262‎. Web of Science, PubMed, Scopus, and Google Scholar was systematically searched until January 2023, and a manual search was performed using the reference lists of included studies. Two authors independently selected the studies, extracted data, and evaluated their ‎methodological quality using the Downs and Black checklist. The process was later discussed ‎with a third author.‎
Results: Five studies were included in this review, of which consistent evidence investigating a direct ‎relationship between fatigue and ‎postural control in individuals with multiple ‎sclerosis. All the studies reported negative effects on postural control. Four ‎studies executed walking tests as fatigue protocols, and one study used a strength testing protocol for both legs, which served as a fatigue-inducing activity‎.
Conclusions: The available evidence suggests that individuals with multiple ‎sclerosis may experience postural control deficits due to fatigue. However, the present body of literature exhibits limitations in terms of its quality and methodology. Gender differences, balance, fatigue task, and muscle function are important factors that need to be taken into account when investigating the relationship between fatigue and postural control deficits in MS. Further high-quality research is necessary to comprehend the complex interplay between MS-related fatigue and postural control deficits after physical activity.
Glasdegib, A Hedgehog Signaling Inhibitor Quantification by Development of Validated LC-ESI-MS/MS (QTRAP) Method in Human Plasma
Authors: rao Yamarthi Venkateswara , Chimakurthy Jithendra
Published: May 2023

Cancer medication Glasdegib, created by Pfizer, has FDA approval. It serves as a tiny molecule an inhibitor of sonic hedgehog, a protein that is overexpressed in several cancer types. Like the majority of medications in its class, it inhibits the smoothened form that contains the hedgehog's sonic receptor (SMO). Clinical trials in phase II are ongoing in four instances. One is testing glasdegib's ability to treat myelofibrosis in patients whose condition was resistant to ruxolitinib treatment. We're aware of no method for precisely measuring Glasdegib, an anti-cancer medication, in biological fluids at the moment. A novel, simple& robust LC-MS/MS method was developed in to detect Glasdegib in a biological fluid. Here, we came up with a novel bioanalytical method using isocratic elution with a symmetric C18 column (150 x 4.6 mm, 3.5 µm), acn: 0.1% formic acid (30:70) was used as mobile phase pH of the mobile phase was adjusted to 4.0 using 0.1% formic acid at rate of flow for 1 ml/min. The drug retention was found as 2.622 minutes, and the total analysis time was set for 6 minutes. The Glasdegib calibration curve was drawn at concentrations ranging from 6 ng to 120 ng/ml of Glasdegib, with regression coefficient (r2) of 0.999. System suitability parameters for resolution, tailing factor and theoretical plates, are found in acceptable limits. The recovery studies indicated that 99.94% of the drug can be extracted using the developed method in an acceptable ratio. The results of the matrix effect study show that the matrix has no impact on recovery; the result is 98.55%, and some other validation parameters are accuracy, linearity, robustness, LOD and LOQ are found in acceptable limits. The developed method should follow an analytical approach like precise, sensitive, and accurate for the evaluation of Glasdegib in biological matrix. The results of the accelerated stability studies reveal that the drug is stable under various conditions, according to USFDA Guidelines.
Myocardial protection strategy: Reducing cardiac arrest time to improve myocardial protection in patients undergoing mitral valve replacement accompanying coronary artery bypass grafting
Authors: Yan Wenlong , Han Bo , Wang Yangyang , Zheng Xin , Wu Yuhui , Hu Haoyu , Yang Sumin
Published: May 2023

Background: Compared with isolated mitral valve replacement (MVR) or isolated coronary artery bypass grafting (CABG), MVR + CABG surgery is associated with higher mortality and complication rate. This study investigated the safety and efficacy of the myocardial protection technique to short cardioplegic arrest time in patients who underwent MVR + CABG.
Methods:This study enrolled patients diagnosed with mitral valve disease and coronary artery disease who underwent MVR + CABG between January 2014 and January 2022. The patients were divided into the CABG without cardioplegic arrest (CA) group (novel group) and CABG with CA group (conventional group) according to surgical methods. The baseline data of the two groups of patients were corrected by the propensity score matching (PSM) method. Endpoints assessed were operative mortality (OM), major morbidity (MM)and 5-year follow-up clinical outcomes.
Results: 810 patients (256 in the novel group and 554 in the conventional group) were enrolled in this study. PSM resulted in a total of 460 patients (230 pairs). There was no significant difference in OM between the two groups (6.5% vs 10.8%, P= 0.098). The MM was significantly lower in the novel group than the conventional group (24.3% vs 33.9%, P= 0.024). Mean operation time (285 ± 55 vs 298 ± 60 minutes, P= 0.016), cardiopulmonary bypass (CPB) time (115 ± 33 vs 139 ± 38 minutes, P < 0.001), CA time (66 ± 11 vs 85 ± 16 minutes, P < 0.001), intensive care unit stay time (33.6 ± 12.3 vs 36.6 ± 14.5 hours, P = 0.017) and post-operative length of stay (11.1 ± 3.6 vs 11.9 ± 4.1 days, P = 0.027) were significantly shorter in the novel group than in the conventional group. There was no significant difference between the novel group and the conventional group in terms of death from any cause, valve-related complications, myocardial infarction and any repeat revascularisation in 5 years follow-up.
Conclusions: The novel group is associated with excellent short-term outcomes and comparable medium-term outcomes for patients undergoing MVR + CABG. Myocardial protection strategy to short cardioplegic arrest time in patients undergoing MVR + CABG was surgically feasible, reproducible, and safe.
Determination of electrical facies using MRGC and ANN clustering methods
Authors: Eftekhari Seyedeh Hajar , Memariani Mahmoud , Maleki Zahra , Aleali Mohsen , Kianoush Pooria
Published: May 2023

The present research was performed on Iran's most crucial reservoir formation (Asmari Formation) in the Mansouri oil field in southwest Iran. This Formation is generally composed of carbonate lithologic, but it has sandstone layers in some zones. It is also the youngest reservoir rock in Iran. In the first step, the lithology of the Asmari Formation was determined by cross-lithology diagrams, and a combination of lime, dolomite, anhydrite, and sandstone with shaley layers was estimated. Also, in the sequence of this geological/reservoir zoning formation, five zones were identified with different geological/reservoir conditions, and the average of each of these petrophysical parameters was calculated in each zone, with the best reservoir quality in zones 3 and 5 with sandstone/shale lithology. Also, this study determines facies clustering methods MRGC and ANN and reading of gamma, neutron, density, acoustic and resistivity diagrams, facies having common geological/reservoir conditions in different subdivisions. For this purpose, the combined log readings of DT, RHOB, GR, Sw, NPHI, and PHIE were used. After applying the software (Geolog) method, an optimal model with 8 clusters (facies) was obtained. The reservoir features and plots in the software for better separation of rock species studied. Finally, five facies with different lithological compositions and reservoir conditions were identified in this study. The information obtained from determining electrical facies by clustering method determines the reservoir zone from non-reservoir and qualitatively (good, medium, and poor) of Mansouri oilfield were achieved.
Association between specialist pediatric cardiac transfer and prognosis of neonates with critical congenital heart disease: A cohort study
Authors: Li Chunxiang , Gong Xiaolei , Xu Zhuoming , Liu Jinlong , Zhang Haibo , Zhu Limin
Published: May 2023

Objective: To explore whether specialist pediatric cardiac transfer could improve the prognosis of neonates with critical congenital heart disease (CCHD).
Methods: This cohort study retrospectively collected the clinical data of neonates diagnosed with CCHD who underwent treatment at the cardiac intensive care unit of Shanghai Children’s Medical Center between January 2018 and December 2021. The neonates were classified into the specialist pediatric cardiac transfer (SPCT) and non-SPCT groups. Propensity score matching (PSM) was used to match the two groups. The surgical outcome was the postoperative survival of the neonates.
Results: During the study period, 357 neonates with CCHD were treated and included, of which 16 died before surgery, all in the non-SPCT group. After PSM, compared with the non-SPCT group, the SPCT group showed a lower rate of inotropic drug use (57.3% vs. 77.5%, P=0.004), a lower rate of unplanned emergent operation (29.2% vs. 53.9%, p=0.001), a higher total survival rate (92.1% vs. 82.0%, p =0.044), and a lower preoperative mortality rate (0% vs. 4.5%, p =0.043). The multivariable analysis showed that body weight at surgery (HR=0.444, 95%CI: 0.273-0.711, p=0.001) and unplanned emergent surgery (HR=5.227, 95%CI: 2.521-10.834, p<0.001) were independently associated with mortality in neonates with CCHD.
Conclusion:Low body weight and unplanned emergency surgery are independent risk factors for the death of neonates with CCHD. Although SPCT is unrelated to the surgery mortality rate of newborns with CCHD, it can reduce the incidence of unplanned emergency surgery and increase the total survival rate.
Comparison of the relative expression of the IGF gene family in the bone marrow of patients with AML compared with normal individuals
Authors: Moonesi Mohammadreza , Omran Hanie Mehdizade , Khosravi Saeed Zaka , Ramshe Samira Molaei , Farsani Mehdi allahbakhshian , Solali Saeed , Hagh Majid Farshdousti
Published: May 2023

Introduction:
One of the most common types of leukemia is acute myeloid leukemia (AML). Intrinsic and extrinsic factors may lead to AML. Insulin-like growth factor (IGF) is a mitogenic intermediate from the liver that regulates growth and proliferation in response to GH. In this study, we examined the expression of IGF family genes in AML patients (M3 and Non-M3) and compared them with normal samples.
Methods
Forty bone marrow samples from recently diagnosed AML patients along with 15 samples from subjects without hematological malignancies were collected. For molecular tests, RNA extraction and cDNA synthesis were performed. Finally, IGF1, IGF2, IGFBP3, IGF1R, and IGF2R gene expression were examined by Real-Time PCR.
Results
IGF1, IGF1R, and IGFBP3 gene expression were significantly increased in patients with AML. In contrast, IGF2 and IGF2R genes did not show significant expression changes between the two groups.
Conclusion
The expression in this gene family soared in AML patients' bone marrow, compared to normal subjects. This can be caused by malignant cells in the bone marrow. These malignant cells express proteins that increase the number of malignant cells. Moreover, they can be considered as diagnostic biomarkers or therapeutic targets with further research.
Characterization and synthesis of mesoporous silica nanoparticles modified using Zn, NH2, and graphene oxide containing Doxorubicin and assessment of its apoptosis induction, cytotoxicity, and anti-metastatic effects on MDA-MB-231 cell line
Authors: Akhtari Niyayesh , Tafizi Farzaneh , Naseh Vahid
Published: May 2023

In the current study, Mesoporous silica nanoparticles (MSNs) were provided and functionalized using zinc, amine, and graphene oxide (GO) (MZNG). Then, they were applied to deliver Doxorubicin, an anticancer drug, to breast cancer cells. The characterization findings indicated that MZNG loaded with DOX had a smooth surface and a spherical shape without homogeneous distribution with a particle size of around 215 nm. The high entrapment efficiency of DOX was observed for MZNGs at pH 7.4. Cytotoxicity results indicated that free DOX had high compatibility with HFF cells compared to DOX loaded into MZNG formulations, while DOX-loaded nanoparticles significantly increased the cytotoxicity against MDA-MB-231compared to free drugs and non-loaded nanoparticles. Moreover, DOX-loaded nanoparticles displayed increased apoptotic potential in MDA-MB-231 compared to free DOX and non-loaded nanoparticles (MZNGs). Upon treatment with samples, a downregulation of MMP-9 and Bcl-2 genes and an upregulation of Bax, Caspase 3, and Mir-193 genes were found. The prepared Nano-formulation holds great promise for treating breast cancer.
Magnetic properties of roadside dust: A case study in Baghdad City, Iraq
Authors: Ameen Nawrass , Khwedim Kareem
Published: May 2023

Magnetic measurements were carried out on roadside dust from the main urban area of Baghdad City, Iraq. The area is heavy traffic as the highway passes through the area from the southern provinces and the roadside represents an effective trap for dust. Concentration-related magnetic parameters, such as magnetic susceptibility (χ), anhysteretic remanent magnetization (ARM), saturation isothermal remanent magnetization (SIRM), and S-ratio of samples had been measured for four areas (A, B, C, and D). Results showed that a magnetite-like phase prevails the magnetic phases of the street dust. Concentration-dependent magnetic parameters of samples increased on the main roads. Mass-specific magnetic susceptibility (ꭕ) is strongly correlated with the susceptibility of Anhysteritic remanent magnetization (χARM) where the correlation coefficients are 0.7 and 0.9, respectively, indicating that the major participant is ferro(i)magnetic minerals (magnetite). S-ratio supports our hypothesis as the mean values were 0.96, 0.95, 0.97, and 0.96 for the four areas (A, B, C, and D), respectively. The primary anthropogenic sources of street dust magnetic particles are vehicle emissions, tire abrasion, and building materials. These findings enable the use of magnetic techniques as straightforward, quick, and non-destructive tools for determining the levels of heavy metal contamination during the process of urbanization.
Microbiome analysis of chronic suppurative otitis media and middle-ear cholesteatoma in China
Authors: Liang Qiulin , Long Ruiqing , Li Shuling , Jiang Chaowu , Gao Jingyu , Cheng Sheng , Liu Zhuohui , Ruan Biao
Published: May 2023

Here, the bacterial diversity in chronic suppurative otitis media (CSOM) and middle-ear cholesteatoma (MEC) was analysed. Nine and twenty-nine patients with CSOM and MEC, respectively, were recruited. Middle-ear lesion tissue was collected intraoperatively after opening the tympanic sinus and mastoid cavity under general anaesthesia and sterile conditions. The full-length 16S rRNA genome sequenced using third-generation sequencing (TGS) was then used to profile the bacterial community of each patient. Principal coordinate analysis showed that PC1 and PC2 could explain more than 50% of the between-group differences. Similarity analysis using the binary Jaccard distance matrix indicated that between-group differences were greater than within-group differences (P < 0.05). Staphylococcus aureus was the most common strain in both groups. At the species level, the abundance of Anaerococcus_octavius was significantly different between both groups (P < 0.05). According to the linear discriminant effect size analysis, at the class and genus levels, Alphaproteobacteria and Bacillus were abundant in the CSOM group, respectively. Peptoniphilus_grossensis and Peptostreptococcaceae_bacterium_oral_taxon_929 were abundant at the species level in the MEC group (P < 0.05). Four COG (Clusters of Orthologous Groups ) functions at level 2 were significantly different between the two groups (P < 0.05). The CSOM and MEC groups were inhabited by more diverse microbial communities. This could guide the regular use of antibiotics and decrease the likelihood of multidrug-resistant bacteria formation. Further research on the pathogenic diseases of CSOM and MEC will focus on the functional differences between flora.
In-Silico Drug Designing of Anti-Polymerizing Activity of Caffeic acid derivatives for the Treatment Of Sickle Cell Disease
Authors: Verma Deepshikha , namdeo KP
Published: May 2023

A series of novel caffeic acid derivatives that were designed utilizing autodock vina software are being developed as a potent anti-sickling agent in an effort to produce anti-polymerizing activity that will lessen complications in sickle cell disease. When different chemical groups are substituted on the hydroxyl benzaldehyde ring at the meta-position to create caffeic acid analogues, docking studies reveal strong binding affinity to the protein's active region. The results of this study may lead to the development of more effective anti-sickling therapies. Caffeic acid, in its many forms, is one of the most promising secondary metabolites for the treatment of a wide range of illnesses and diseases. The toxicity & biological activity of 8 chemicals are analyzed in this study using ADMET and Auto dock vina software for calculating binding score. Out of 8 compounds from the Caffeic acid derivatives substitution at meta position can be regarded as the safest showing best binding affinity can be further synthesized to get new drug.
Impact of Microfinance Credit Access on Household Income and Welfare: Evidence from Ethiopia
Authors: Wassie Asmamaw Getnet
Published: May 2023

This study examined the impact of microfinance credit access on households’ income and welfare case study in rural South Gondar zone, Ethiopia. The main objective of the study was investigating the impact of microfinance credit access on households’ income and welfare. The study used cross sectional data. The study surveyed 422 households. Half of the surveyed households were credit takers but not the remaining. The treatment variable (D) of the study is credit access. The outcome variables of the study are households’ income and welfare. The study employed both descriptive and econometric model to achieve the objective of the study. The propensity score matching (PSM) was employed in the econometric part of the study to estimate the impact of the credit on outcome variables of the study. Among matching methods, kernel (0.1) was employed since it satisfies the criterion of best matching between treatment unit and controlled unit. The study found that average treatment effect (ATT) on the treated group in terms of income is less than its counterpart. However, average treatment effect (ATT) on treated group in terms of welfare is greater than its counterpart.
Investigation of double layer corrugated steel plate shear walls in multi-story frames
Authors: Kiani Mahdi , Enayati Hamed
Published: May 2023

The flat steel plate shear walls (FPSW) are widely used as a part of lateral force resisting systems, however easily buckle under lateral cyclic loads. As an alternative are corrugated steel plate shear walls (CPSW) in which the infill flat steel plate is replaced with a corrugated steel plate. CPSW has some advantages over FPSW such as in-plane and out of plane stiffness, strength and ductility. Despite these advantages, the applicable thickness of corrugated plates due to the instrumental capability is limited thus, a double layer corrugated steel plate shear wall (DCPSW) composed of two similar corrugated steel plates was introduced. As previous studies in this context more focused on single-story frames and there is not a rich literature on DCPSW systems, in this paper, 48 two-dimensional multi-story frames were numerically studied under monotonic pushover lateral excitations. According to results, corrugated shear walls have less lateral strength comparing to FPSW and with increasing story numbers the difference are smaller. The corrugated walls are more ductile, especially in the case of shorter frames. In addition, Frames with DCPSWs are associated with the highest inelastic deformations which can be considered as an advantage over CPSWs.
Valorization of sweet potato (Ipomoea batatas) leaves by producing a novel herbal tea and its fermentation with kombucha consortium
Authors: Weber Caroline Trevisan , Angnes Fabiane , Carvalho Débora Gonçalves , Trierweiler Luciane Ferreira , Trierweiler Jorge Otávio
Published: May 2023

Tea and kombucha consumption has increased in recent years. Despite the big Brazilian sweet potato production, the leaves are generally discarded. This work aims to evaluate the potential of using this residual raw material to produce tea and kombucha and analyze its phenolic profile. Sweet potato leaves' tea presented a total phenolic content higher than the commercial herbal teas evaluated and an antioxidant capacity similar to chamomile and fennel teas. For kombucha, a blend of up to 75% of sweet potato leaves' tea can be used and still match the phenolic content of the commercial kombuchas. The sweet potato leaves' tea and kombucha phenolic profile performed by LC-MS consisted of: quinic, chlorogenic, dicaffeoylquinic, ferulic, and azelaic acids; rutin, and a compound derived from quercetin. These compounds present several health benefits, suggesting that producing tea and kombucha from sweet potato leaves is an excellent opportunity to add value to this material.
Determination of the Androgen Receptor Status of Disseminated Tumor Cells in Primary Breast Cancer Patients
Authors: Natalia Krawczyk , Jäger Bernadette , Martina Piperek-Jäger , Cristina Lopez-Cotarelo Rodriguez-Noriega , Melissa Neubacher , Maggie Banys-Paluchowski , Franziska Meier-Stiegen , Hans Neubauer , Dieter Niederacher , Eugen Ruckhäberle , Svjetlana Mohrmann , Jürgen Hoffmann , Thomas Kaleta , Irene Esposito , Tanja Fehm
Published: May 2023

Purpose Androgen receptor (AR) can serve as a new therapy target since it was shown to play a proliferative role in several BC subtypes. Moreover AR-positivity has been suggested to reflect the metastatic potential of tumor cells in some of BC subtypes. The aim of this study was to determine the AR-expression on disseminated tumor cells (DTCs) as a surrogate marker of minimal residual disease (MRD) and potential precursor of metastasis in early BC. Methods Bone marrow (BM) aspirates from 62 DTC-positive early BC patients were included into this study and analysed by immunofluorescence triple staining for the presence of AR-positive DTCs. CK-positive, CD45-negative cells that contained an intact nucleus (DAPI-positive) were identified as DTCs. The AR expression of the PT was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded (FFPE) tumor sections from core biopsies and surgical specimens. Results AR-status of DTCs could be determined in 21 patients and 9 of those (43%) had AR-positive DTCs. No correlation could be found between positive AR-status of DTC and any of the clinicopathological factors. AR expression of DTC and corresponding PT showed a concordance rate of 33%. No significant correlation could be observed between the AR status of the PT and any of the established prognostic factors for BC. Conclusion AR-positive DTCs can be detected in BM of early BC patients with a marked discordance of the AR status between DTCs and corresponding PTs. The clinical significance of these findings needs further investigation.
Variation of floristic diversity, community composition, endemism, and conservation status of tree species in tropical rainforests of Sri Lanka across a wide altitudinal gradient
Authors: Sanjeewani Nimalka , Samarasinghe Dilum , Jayasinghe Himesh , Ukuwela Kanishka , Wijetunga Asanga , Wahala Sampath , De Costa Janendra
Published: May 2023

Tropical rainforests in Sri Lanka are considered as biodiversity hotspots. However, their existence is threatened by multiple climatic and anthropogenic drivers. Our objective was to assess the diversity, endemism and conservation status of these rainforests across a wide altitudinal range. We conducted a complete census of all trees having ≥ 10 cm diameter at breast height in ten one-hectare permanent sampling plots of tropical rainforests from 100 to 2200 m above mean sea level and determined altitudinal trends in tree diversity, floristic composition, endemism and conservation status of tree taxa. While community-scale tree diversity decreased with increasing altitude, substantial altitudinal differentiation of tree taxa was observed. Increasing day-night temperature difference (DTR), decreasing rainfall and increasing cumulative maximum soil water deficit (CSWDmax) with increasing altitude decreased tree diversity and the percentage of endemic species while increasing the percentage of endangered species. These trends show that the ability to colonize the higher altitudes, where lower temperatures and higher soil water deficits act as climate constraints, is a major determinant of tree diversity and endemism in Sri Lankan rainforests across altitude gradients. This hypothesis is supported by the observed increases of the percentages of endangered and vulnerable species from mid- to high altitudes. Most of the dominant species at different altitudes were endemic and are endangered or vulnerable. We conclude that the decrease in diversity and endemism is most likely driven by cold- and drought-sensitivity of these predominantly tropical-adapted tree species so that conservation efforts are most needed at altitudes above 1000 m.
Research on concentration detection algorithm of embedded gas detection system based on deep learning
Authors: Sun Shuyong
Published: May 2023

In daily life, whether it is the house where people live or the car they drive, air pollution can be seen almost everywhere, and human life and health are seriously threatened. There is an urgent need for a detection system for fast and accurate detection and assessment of ambient air quality. On the other hand, in the medical field, the detection of human exhaled gas can realize non-invasive and rapid early disease screening, but to achieve this purpose, a fast, accurate, highly sensitive and selective gas detection system is also required. At present, the research and development of gas detection system has attracted more and more attention of scholars, and the gas detection technology using porphyrin sensor array (PSA) chip is a hot topic in this research direction in recent years. Compared with traditional methods, this method has many obvious advantages and can meet the needs of fast, accurate and sensitive detection. In this paper, a PSA chip is used as a gas sensor, a set of PSA image acquisition and processing software is designed and developed on the Linux platform, and successfully transplanted to the ARM platform to build a complete gas detection system. Next, the data was collected and processed with ammonia gas as the detection object, and the quantitative analysis model of gas concentration was studied.
To compare the treatment of intrabony defects with autogenous periosteal grafts as a barrier membrane in chronic periodontitis patients: A systematic review and meta-analysis.
Authors: Bhandare Jui , Mahale Swapna , Abullais Saquib S. , AlQahtani Saad M. , Khalid Imran
Published: May 2023

To evaluate the effectiveness of autogenous periosteal graft as a barrier membrane on the clinical parameters when used in the treatment of intrabony defects in chronic periodontitis patients. Four databases MEDLINE (by PubMed), Cochrane database, EBSCO, and Google Scholar were explored to identify studies in English up to December 2022. Three independent reviewers screened the retrieved articles using the particular inclusion criteria. Randomized control trials (RCTs) evaluating the effectiveness of autogenous periosteal grafts used in the treatment of intrabony defects in chronic periodontitis patients were included in the study. Outcome variables examined were pocket depth (PD), clinical attachment level (CAL), radiographic bone defect fill (BDF), gingival recession (GR), plaque index (PI), gingival index (GI), bleeding on probing (BOP). The mean differences and 95% confidence interval were used to illustrate the estimate of effect size. Six relevant articles were recognized for data procurement. A total of 117 patients with 68 sites and an age range between 18 years and 55 years were selected as paricipants.There was an equal effect in both groups for PI, GI and BOP reduction. For PD reduction, the result was in favor of periosteal graft with open flap debridement (OFD). For CAL gain, radiographic BDF and GR, the results also favored the periosteal graft but no statistically significant difference was found. Within the limitations of the study, it seems that the autogenous periosteal graft can be used successfully along with OFD to treat intrabony defects in chronic periodontitis patients.
Bestandssituation ausgewählter hochmontaner, präalpiner und subalpiner Pflanzenarten im westlichen Teil des Erzgebirges (Sachsen, Deutschland) und dessen näherer Umgebung. 1. Teil
Authors: Breitfeld Matthias , Baumann Angelika , Riether Wolfgang
Published: May 2023

Auf Grundlage aktueller Kartierungsdaten und bereits vorhandener Datensätze wird im ersten Teil dieser Arbeit die Verbreitung von Athyrium distentifolium, Epilobium alpestre, Rumex arifolius, Scorzoneroides autumnalis subsp. borealis, Senecio hercynicus, Senecio ×decipiens, Streptopus amplexifolius und Tephroseris crispa im Erzgebirge (Sachsen, Deutschland) dargestellt. Bezogen auf das jeweilige Gesamtareal handelt es sich insofern um pflanzengeografisch besondere Arten, da diese in Sachsen fast nur im Erzgebirge vorkommen und auch deutschlandweit nur disjunkt in höheren Gebirgslagen anzutreffen sind. Die Entwicklung der Nachweise wird durch nach Zeitabschnitten gestaffelte Symbole dokumentiert.
Hinweise zu Literatur über Geschichte, Sammlungsbestände, Typus-Kollektionen und Sammler institutioneller Herbarien in Deutschland
Authors: Gottschlich Günter
Published: May 2023

Vorliegende Arbeit bringt eine Zusammenstellung von 559 Literaturnach­weisen über öffentliche Herbarien in Deutsch­land, ihre Geschichte, Sammlungsbestände, Typus-Kollektionen und Sammler. Die Zusam­menstellung ist geographisch nach Bundeslän­dern gegliedert.
Weitere Ergebnisse der Arbeitsgruppe Durchflusszytometrie: Aira, Senecio und Scrophularia
Authors: Gregor Thomas , Amarell Uwe , Berghofer Michaela , Niederbichler Christian , Otto Rainer , Paule Juraj , Schröder Christof Nikolaus , Mutz Sabine
Published: May 2023

Durchflusszytometrische Ploidiebestimmungen von untersuchten Senecio-Arten lassen auf Tetraploidie schließen. S. aquaticus aus dem Alpenvorland wies geringere relative DNA-Gehalte als Pflanzen aus anderen Gebieten auf. Messungen von Scrophularia umbrosa s. l. bestätigen und ergänzen die bisher bekannte Verbreitung von S. neesii und S. umbrosa s. str. in Deutschland. Messungen von Aira ergaben keinen Hinweis auf ein Vorkommen von A. multiculmis an den untersuchten Standorten.
Beiträge zur Fortschreibung der Florenliste Deutschlands (Pteridophyta, Spermatophyta) – Fünfzehnte Folge
Authors: Hand Ralf , Gottschlich Günter
Published: May 2023

Eine Auswahl von Fällen taxonomischer und nomenklatorischer Änderungen in der aktuellen Florenliste Deutschlands (Version 13, 2023) wird besprochen. Für den Namen Arenaria multicaulis subsp. moehringioides erfolgt die Validierung ebenso wie für den bisher nicht gültig veröffentlichten Namen Nasturtium sterile. Diskutiert werden unter anderem die Taxa und Namen Biscutella laevigata subsp. subaphylla, Centaurium capitatum, Elymus tallonii, Orobanche picridis-hieracioidis (mit Priorität gegenüber O. picridis) und Veronica angustifolia. Bei letzterer wird die Verwendung des Namens V. bastardii angeraten. Hinzu kommen Klärungen bei Hieracium pseudosulphureum und H. suprafloccosum durch Günter Gottschlich. Analysiert werden ferner die infraspezifischen Rangstufen, die Petermann (1838) in seiner „Flora Lipsiensis excursoria“ verwendet.
HALAL LIFESTYLE INDONESIA: REVIEW OF HALAL PRODUCT DEVELOPMENT IN SHARIA ENTERPRISE THEORY (SET) PERSPECTIVE
Authors: Andriani Andriani
Published: May 2023

Abstrak: Penelitian bertujuan untuk menganalisis pengembangan produk halal dalam pemenuhan kebutuhan halal lifestyle di Indonesia. Penggunaan tinjauan sharia enterprise theory untuk menunjukan hal-hal penting yang harus diperhatikan bagi seluruh perusahaan yang memproduksi barang atau jasa. Penelitian ini merupakan penelitian kualitatif dengan menggunakan analisis deskriptif. Analisis ini digunakan untuk memberikan deskripsi atau gambaran mengenai subjek penelitian berdasarkan data variabel yang diperoleh dari kelompok subjek tertentu. Hasil penelitian ini menjelaskan bahwa Allah SWT sebagai stakeholder utama, pemilik seluruh sumber daya di muka bumi. Maka penting bagi pelaku usaha bertanggung jawab pada Allah SWT dengan pengelolaan produk sesuai kegiatan dalam syariat Islam. Kemudian tanggung jawab pada manusia merupakan wujud untuk meningkatkan kepedulian antar sesama dan pengembangan produksi dengan tenaga seorang pekerja. Lalu tanggung jawab pada lingkungan, menjadi perhatian penting bagi pelaku usaha agar dapat terus mengembangkan produk dengan memperhatikan pelestarian lingkungan.

Kata kunci: Halal Lifestyle; Produk Halal; Sharia Enterprise Theory

 

Abstract: The research aims to analyze the development of halal products in fulfilling the needs of halal lifestyles in Indonesia. Sharia enterprise theory reviews show important things that must be considered for all companies that produce goods or services. This research is qualitative research using descriptive analysis. This analysis is used to provide a description or description of the research subject based on variable data obtained from certain subject groups. The results of this study explain that Allah SWT is the main stakeholder, the owner of all the resources on earth. So it is important for business actors to be accountable to Allah SWT by managing products according to activities in Islamic law. Then the responsibility to humans is a form of increasing concern among others and developing products with the power of a worker. The responsibility for the environment becomes an important concern for business actors so that they can continue to develop products with due regard to environmental preservation.

Keywords: Halal Lifestyle; Halal Product; Sharia Enterprise Theory
ANN-based PCA to predict evapotranspiration: a case study in India
Authors: Abraham Marykutty , Mohan Sankaralingam
Published: May 2023

The Penman–Monteith evapotranspiration (ET) model has superior predictive ability to other methods, but it is challenging to apply in several Indian stations, owing to the need for a large number of climatic variables. The study investigated an artificial neural network (ANN) model for calculating ET for various agro-climatic regions of India. Sensitivity analysis showed that the overall average changes in ET0 values for 25% change in the climatic variables were 18, 16, 14, 7, 5, and 4%, respectively, for Tmax, RHmean, Rn, wind speed, Tmin, and sunshine hours. The dominant climatic variables were identified from the principal component analysis (PCA) and ET0 was computed using an ANN with dominant climatic variables. The ANN architecture with backpropagation technique had one hidden layer and neurons ranging from 10 to 30 for all climatic variables and from 5 to 10 for PCA variables. The new ET models were statistically compared with Penman–Monteith ET estimate, and found reliable. PCA variables guaranteed an estimate of ET0 accounting for 98% of the variability. The average values of coefficient of determination, standard error of estimate, and percentage efficiency were observed as 0.96, 0.24, and 94%, respectively.
Reflexões sobre a atuação dos condutores de visitantes
Authors: Barbosa de Almeida Antonio Rafael , Magalhães da Rocha Andréia
Published: May 2023

As consequências da pandemia da Covid-19 nas atividades econômicas e nas mobilidades humanas têm exposto um amplo espectro de conflitos e contradições no contexto do fenômeno turístico, dentre as quais as que atingem o mundo do trabalho e os trabalhadores do turismo estão entre as mais dramáticas e urgentes. Tem-se, diante desse cenário, o enfoque sobre a exposição das carências e das fragilidades da atuação dos condutores de visitantes destacadas a partir da interrupção parcial da movimentação turística e o fechamento temporário das unidades de conservação do país em 2020. O presente trabalho, de natureza exploratória, faz uso de uma abordagem qualitativa, utilizando-se da pesquisa bibliográfica e documental e tem como objetivo principal identificar e refletir a respeito das fragilidades e precariedades da atuação dos condutores de visitantes considerando, sobretudo, o cenário e as implicações da pandemia da Covid-19 na atividade turística. Diante disso, buscou-se compreender as lacunas e as vulnerabilidades na proteção aos condutores de visitantes, com atenção, para mudanças repentinas ou crises, como às trazidas por pandemias e outros eventos disruptivos, e como estas afetam a dinâmica do turismo, com destaque para o trabalho. Aponta-se, deste modo, além das evidentes contribuições oferecidas por esta ocupação ao desenvolvimento da visitação e do turismo nos diversos ambientes naturais protegidos, a necessidade da maior compreensão sobre o perfil desses profissionais, de seus meios de organização, bem como a limitada proteção jurídica dedicada aos mesmos e a insuficiência de medidas governamentais que venham a minimizar os efeitos da paralisação de suas atividades.