bluuebunny/crossref_metadata_2025 huggingface dataset:
Decolonization
Authors: McMullin Juliet
Published: February 2025

Much has been written about decolonizing practices in the academy. This essay engages the conversation by focusing on the analysis phase of research to consider how research continues to be a process of colonization and epistemicide. Advances in community‐engaged research (CEnR) ameliorate some issues of inclusion. Yet, institutional procedures and claims to methods that entrench a scientifically enlightened way of knowing continue to systematically exclude Indigenous knowledge and many other systems of knowledge. Indeed, Tuck and Yang's question about what is distinct and sovereign, remains. Drawing on the analysis phase of a CEnR project with Native Americans, we describe our process for centering Indigenous epistemologies. While data gathering and analysis were inclusive, we were not always successful in maintaining the community partner's sovereignty. This example demonstrates the challenges of institutions that long for us to forget that there are other ways of knowing, and the promises of relational thinking and being as anti‐oppressive, though not yet decolonized research. Pausing to examine our practices during the analysis phase of research allows us to ask and enact different forms of relationality and reimagine how we come to know.
The Role of Illness Perception and Help‐Seeking Attitudes on Positive Psychological Well‐Being and Quality of Life in People With Chronic Wounds
Authors: Liu Yingchun , Wu Bin , Yu Jiping , Su Rong , Hong Yaping , Shi Qiong , Chen Ping , Zhang Jianfang
Published: February 2025

Chronic wounds are a substantial health burden, adversely affecting patients' overall quality of life. This study explored the association between positive psychological well‐being and quality of life and the mediating roles of illness perceptions and attitudes toward medical help‐seeking among people with chronic wounds. A total of 208 people with chronic wounds from three hospitals in China were recruited. Data were collected using the Brief Illness Perception Questionnaire, Attitudes Toward Medical Help‐Seeking Scale, the Well‐being in Wounds Inventory, and the Questionnaire on Quality of Life with Chronic Wounds. Participants reported poor health‐related quality of life. The structural equation model revealed that the overall indirect impact of positive psychology on quality of life was 38.93%. This impact was divided into three components: disease perception accounted for 26.67% of the total indirect effect, attitude toward medical care accounted for 8.50%, and the combined effect of both factors accounted for 3.75%. This suggests that higher positive psychological well‐being may lead to higher quality of life by reducing illness perception and improving attitudes toward medical help‐seeking.
Idiosyncrasy of feather mite intensity and prevalence across passerine bird species: a comparative study
Authors: del Mar Labrador María , Gonzalez-Voyer Alejandro , Serrano David , Aguilera Eduardo , Arroyo José L. , Atiénzar Francisco , Barba Emilio , Bermejo Ana , Blanco Guillermo , Borràs Antoni , Calleja Juan A. , Cantó José L. , Cortés Verónica , De la Puente Javier , De Palacio Diana , Fernández-González Sofía , Figuerola Jordi , Frías Oscar , Fuertes-Marcos Benito , Gordo Oscar , Kovács István , Martínez José L. , Meléndez Leandro , Mestre Alexandre , Møller Anders P. , Monrós Juan S. , Moreno-Opo Rubén , Navarro Carlos , Pap Péter L. , Pérez-Tris Javier , Piculo Rubén , Ponce Carlos , Rodríguez Rubén , Sallent Ángel , Carlos Senar Juan , Tella José L. , Vágási Csongor I. , Vögeli Matthias , Jovani Roger
Published: February 2025

Symbionts are key elements of ecosystems, by playing important roles in shaping the biology and ecology of their hosts. However, the factors determining symbiont loads across host species are still unclear. Nowadays, we know that the intensity and prevalence of feather mites, the most diverse group of avian ectosymbionts, differ strongly between species. To understand those differences, we studied 17 bird species traits and two feather mite community features (species richness and composition in bird species) potentially related to interspecific differences in feather mite intensity and prevalence across bird species. We analyzed a large dataset of feather mite occurrence across European passerines: for feather mite intensity a sample of 27 424 birds from 119 bird species, and 1 805 566 feather mites counted, and for prevalence a sample of 76 126 birds from 122 bird species. Feather mite intensity and prevalence covaried positively across bird species, reinforcing the previous observation that species differ in feather mite load. Comparative analyses of the association of bird traits and feather mite richness with feather mite intensity or prevalence showed a moderate explanatory power, high model selection uncertainty, inconsistent results for both prevalence and intensity data, and contrasting results with previous comparative studies on feather mite occurrence. Furthermore, even though closely related bird species had similar feather mite communities, there was a low evolutionary conservatism of both the prevalence and intensity of feather mites across bird species (i.e. low phylogenetic signal). Finally, feather mite community composition did not explain feather mite intensity or prevalence across bird species. Overall, our large number of host and mite traits failed to satisfactorily explain the high variability in feather mite occurrence across bird species. We discuss that this difficult‐to‐understand apparent idiosyncrasy of bird species in their feather mite intensity and prevalence may be the outcome of the interaction between host and symbiont traits.
Plants as biofactories for production of the aphid sex pheromone nepetalactone
Authors: Ontiveros‐Cisneros Abraham , Salfeld Jule , Ding Bao‐Jian , Wang Hong‐Lei , Moss Oliver , Friberg Magne , Van Moerkercke Alex , Löfstedt Christer , Van Aken Olivier
Published: February 2025

Aphids cause massive agricultural losses through direct damage or as pathogen vectors. Control often relies on insecticides, which are expensive and not selective. An interesting alternative is to use aphid sex pheromones nepetalactone (NON) and nepetalactol (NOL) to interfere with aphid mating or attract aphid predators. Here, we explore production of these compounds in plants, as their precursors can be derived from mevalonate (MVA) and methylerythritol phosphate (MEP) pathways. By introducing six genes, including a major latex protein‐like (MLPL) enzyme, we engineered a functional nepetalactol biosynthetic pathway into plants. Transient expression of these enzymes in N. benthamiana caused production of nepetalactone, without the need for external supplementation with substrates. Targeting all six enzymes into the chloroplast appeared to result in higher NON yields than just chloroplast‐targeting the first two enzymes. We could not detect NOL, suggesting it is rapidly oxidised to NON. In addition, we produced NON in stably transformed Camelina sativa (Camelina) lines. Interestingly, the specific NON enantiomer was different in N. benthamiana compared to in Camelina, indicating the value of different platforms for producing specific isoforms. This opens possibilities for using plants as green factories of pheromones for baits or as pheromone dispensers that interfere with insect behaviour.
The Cyclin‐Dependent Kinase activity modulates the central carbon metabolism in maize during germination
Authors: Lara‐Núñez Aurora , Garza‐Aguilar Sara Margarita , Páez‐Franco José Carlos , de Dios Galindo‐de‐la‐Rosa Juan , Vallejo‐Becerra Vanessa
Published: February 2025

The cell cycle is predominantly controlled by Cyclins/Cyclin‐Dependent Kinases (Cyc/CDK) complexes, which phosphorylate targets involved in cellular proliferation. Evidence suggests that Cyc/CDK targets extend beyond traditional proteins and include enzymes that regulate the central carbon metabolism. Maize embryo axes rapidly internalize and metabolize glucose. After 24 h of imbibition in glucose‐rich media, axes exhibited increased length and weight, with more pronounced effects at 72 h. This morphology enhancement was impaired when RO‐3306, a specific CDK inhibitor, was added. The protein profile of maize embryo extracts at 18 and 24 h indicated altered phosphorylation patterns following CDK activity inhibition. Metabolomic analysis at 24 h of imbibition revealed that maize embryos without sugar in the media, with or without RO‐3306, had a decreased sugar and amino acid content. Conversely, axes exposed to glucose demonstrated increased conversion into various mono and di‐saccharides such as fructose, mannitol, galactose, and maltose but not sucrose. This pattern was reversed upon the addition of RO‐3306. Glucose promoted the accumulation of amino acids such as cysteine, valine, leucine, and intermediates of the tricarboxylic acid (TCA) cycle, such as malate and citrate. The CDK inhibitor redirected the glucose metabolism toward increased serine levels, followed by other amino acids like phenylalanine, valine, and leucine. Additionally, TCA cycle intermediates and sterols significantly decreased. Overall, these results contribute to understanding the role of CDK in maize morphogenesis during germination and underscore its impact on modulating various central carbon pathways, including glycolysis, amino acid catabolism/anabolism, TCA cycle, and sterols biosynthesis.
The role of institutional factors in shaping university mission statements: A topic‐modeling approach
Authors: Philippczyck Nicole , Hoffmann Harry , Oertel Simon
Published: February 2025

Mission statements are common instruments for the strategic positioning of universities. However, there are few large‐scale, cross‐national studies examining the factors that influence the content of universities' mission statements. We address this research gap, exploring the content of 413 mission statements from European universities by applying correlated topic modeling (CTM). Moreover, relying on institutional theories of organization, we study factors that explain differences in the content of mission statements. Our findings reveal six distinct topics addressed in mission statements. The prevalence of a specific topic is significantly shaped by the cultural rationalization of the universities' national context, the university's founding context, and institutional control. Our findings not only contribute to research on universities' strategic positioning but also shed light on the diffusion of global trends across organizations and the determinants of their adaptation. Moreover, our study offers an illustrative example of how big data analytics can enhance public administration research.
Development and Validation of a Risk Prediction Model to Identify Women With Chronic Obstructive Pulmonary Disease for Proactive Palliative Care
Authors: Gebresillassie Begashaw Melaku , Attia John , Cavenagh Dominic , Harris Melissa L.
Published: February 2025

Background and Objective

Proactive palliative interventions can improve symptom control and quality of life in individuals with chronic obstructive pulmonary disease (COPD); however, they are often underutilised. This study aimed to develop and validate a prediction model to identify women with COPD in their last year of life to facilitate timely palliative care referrals and interventions.

Methods

Data from 1236 women diagnosed with COPD from the 1921–1926 Australian Longitudinal Study on Women's Health cohort, linked to administrative health records, were analysed. We employed Lasso regression and multivariable logistic regression to select predictors. To assess the predictive performance of the model, we used the area under the receiver operating characteristic (AUROC) curve, calibration plot, and calibration metrics. The Youden index was used to establish the optimal cutoff point for risk classification. The clinical utility of the model was evaluated using decision curve analysis (DCA).

Results

The final model to predict 1‐year all‐cause mortality included six predictors: smoking status, body mass index, needing regular assistance with daily activities, number of supplied medications, duration of illness, and number of hospital admissions. The model performed well, with AUROC of 0.82 (95% CI: 0.80–0.85) and showed excellent calibration. Using a cutoff of 56.6% predicted risk, the model achieved a sensitivity of 72.3%, specificity of 77.7%, and accuracy of 75.0%. The DCA indicated that the model provided a greater net benefit for clinical decision‐making.

Conclusion

Our prediction model for identifying women with COPD who may benefit from palliative care has shown robust predictive performance and can be easily applied, but requires external validation.
Goldenhar Syndrome and Its Clinical Manifestation With Dentofacial Considerations: A Case Report
Authors: Somkuwar Jay Kishor , Parasramka Pallavi , Ansari Afroz Alam , Singh Rajeev Kumar
Published: February 2025

Goldenhar syndrome, a variant of hemifacial microsomia, is a rare congenital condition characterized by mandibular hypoplasia, epibulbar dermoids, preauricular tags, and vertebral anomalies. This article discusses the case of a young boy presenting with classical signs of Goldenhar syndrome along with bilateral mandibular second premolar (BMSP) agenesis. While this syndrome can lead to significant physical and functional difficulties, timely recognition and tailored management are pivotal in enhancing the patient's quality of life and long‐term health outcomes.
Toward delirium: Comments on Russell Ford's Experience and Empiricism
Authors: Bell Jeffrey A.
Published: February 2025

This is an invited book symposium submission (invited by Mary Beth Mader). In these comments I summarize the strengths of Ford's recent book on Deleuze's work on Hume. I argue that while Ford has contributed an important book to both the scholarship on Deleuze's early work and on the intellectual history of mid‐twentieth century French philosophy, there are a few issues I seek to flesh out in these comments that are nonetheless in the spirit of Ford's overall project. In particular, I show how Deleuze offers a unique reading of Hume that ought to be taken more seriously by Hume scholars—a point Ford does not stress—and I argue that in addition to the influence of Jean Wahl, which Ford details superbly, the work of Sartre is also critical to understanding Deleuze's early philosophical writings.
Homozygosity for a novel A4GALT allele resulting in the rare p phenotype in an Indian blood donor
Authors: Tilley Louise A. , Karamatic Crew Vanja , Tearle Amy , Datta Suvro Sankha , Thornton Nicole M.
Published: February 2025

Background and Objectives

Individuals with the rare p phenotype have red cells lacking P, P1 and Pk antigens and make clinically significant anti‐PP1Pk. The phenotype arises from inactivating mutations in A4GALT, which encodes the enzyme responsible for production of P1 and Pk. We present results from serological and molecular investigations of a case of anti‐PP1Pk with a novel molecular background of the p phenotype.

Materials and Methods

Samples from a 32‐year‐old Indian blood donor were investigated due to the presence of a pan‐reactive alloantibody, together with samples from his sister and mother. Standard serological investigations and A4GALT sequencing were performed.

Results

The donor was found to have p phenotype, and his plasma contained anti‐PP1Pk. Sequencing revealed a rare homozygous missense mutation in A4GALT (c.526G>A; p.Asp176Asn; rs371893172; frequency 0.00007), representing a novel null allele. The sister was heterozygous for this allele, while surprisingly the mother did not carry the allele. Enquiries revealed the mother was not the donor's biological mother, explaining the perceived discrepant sequencing results.

Conclusion

We have identified homozygosity for a novel A4GALT null allele (carrying c.526G>A, p.Asp176Asn), resulting in lack of functional 4‐α‐galactosyltransferase and a p phenotype, adding to the catalogue of known genetic backgrounds of this rare phenotype.
A structural equation model predicts chronic wound healing time using patient characteristics and wound microbiome composition
Authors: Ancira Jacob , Gabrilska Rebecca , Tipton Craig , Miller Clint , Stickley Zachary , Omeir Khalid , Wakeman Catherine , Little Todd , Wolcott Joseph , Philips Caleb D.
Published: February 2025

Wound aetiology, host characteristics and the wound microbiome contribute to chronic wound development. Yet, there is little accounting for the relative importance of these factors to predict wound healing. Here, a structural equation model was developed to provide such an explanatory and predictive framework. Chronic wounds from 565 patients treated at a clinic practicing biofilm‐based wound care were included. Patient information included DNA sequencing‐based wound microbiome clinical reports corresponding to the initial clinical visit. Wound microbiome data was integrated into the SEM as a latent variable using a pre‐modelling parcel optimization routine presented herein for the first time (available as R library parcelR). A microbiome latent construct associated with improved healing was validated, and the final SEM included this latent construct plus three species associated with diminished healing (Anaerococcus vaginalis, Finegoldia magna and Pseudomonas aeruginosa), as well as smoking, wound volume, slough, exudate, edema, percent granulation and wound etiology. This model explained 46% of variations in healing time, with the microbiome contributing the largest proportion of variance explained. Model validity was confirmed with an independent cohort (n = 79) through which ~60% of the variation in healing time was predicted. This model can serve as a foundation for the development of a predictive tool that may have clinical utility.
Ind‐étale versus formally étale
Authors: Mondal Shubhodip , Mukhopadhyay Alapan
Published: February 2025

We show that when is a reduced algebra over a characteristic zero field and the module of Kähler differentials , then is ind‐étale, partially answering a question of Bhatt. As further applications of this result, we deduce a rigidity property of Hochschild homology and special instances of Weibel's conjecture and Vorst's conjecture without any noetherian assumptions.
Numerical computation of time-averaged acoustic radiation force on arbitrarily-shaped particles using an improved immersed boundary method
Authors: Xie Fangtao , Li Yapeng , Wang Kailun , Qu Yegao
Published: February 2025

This work focuses on the numerical computations of the second-order time-averaged acoustic radiation force on solid particles with complex geometries based on perturbation theory and linear scattering approximation. The acoustic field scattered by arbitrarily shaped particles immersed in inviscid fluid is computed using the finite-difference time-domain method with a fourth-order dispersion-relation-preserving scheme, which serves as the basis for radiation force calculation. The infinite fluid domain is truncated into a finite computational domain by defining perfectly matched layers at computational boundaries. A meticulous immersed boundary method is developed to represent the interface between an irregularly shaped solid and the Cartesian computational grid, improving the precision of the computed acoustic radiation force. Based on the proposed method, the acoustic radiation force acting on a rigid elliptical cylinder exerted by planar standing acoustic waves is computed first, and the accuracy of the computed results is verified by comparing them with reference solutions obtained using the finite element method. Additionally, the dependences of the computational precision of the acoustic radiation force on some key parameters are assessed, and the criterions for determining the parameter values are developed to avoid the excessive constraint phenomenon which may occur in the numerical results. Finally, numerical examples of computing the acoustic radiation force on solid particles with complex geometries are implemented to check the effectiveness of the proposed numerical method.
Management of multiorgan failure caused by immune checkpoint inhibitor toxicity
Authors: Verma Tushita , Jawadi Altamash , Ahmed Shozab
Published: February 2025

Immune checkpoint inhibitors (ICIs) block inhibitory pathways that tumour cells exploit to evade the immune system. They play a key role in the management of aggressive cancers, including non-small cell lung cancer, melanoma and Hodgkin’s lymphoma. Despite their efficacy, ICIs can cause severe, potentially fatal, immune-related adverse events (irAEs), including multiorgan failure. We present a case of a woman in her early 70s with metastatic lung adenocarcinoma recently initiated on pembrolizumab who presented with an acute stroke complicated by irAE-related multiorgan failure. Despite aggressive treatment, the patient remained critically ill and passed away the same day after transitioning to end-of-life care. This case emphasises the life-threatening potential of irAEs, the importance of early diagnosis and the challenges of managing these complications. Clinicians should maintain a high index of suspicion for irAEs in ICI-treated patients to optimise timely intervention and outcomes.
Cardiac stress in a child with perioperative anaphylaxis
Authors: Sharma Vibha , Parkes Andrew , Diacono Jacques , Khan Sophia
Published: February 2025

A case of cardiac stress following a grade 4 perioperative anaphylaxis was identified. We speculate that this may be a case of Kounis or adrenaline, takotsubo, anaphylaxis and Kounis (ATAK) complex. This is the first such case reported from the UK. We propose performing routine cardiac investigations in patients with grade 4 anaphylaxis or chest pain following anaphylaxis to evaluate any similar future presentations.
Implications for developing global health education in China: evidence from an undergraduate teamwork with role-play
Authors: Cai Yi , Chen Hong , Wu Chenkai , Joarder Taufique , Pang Junxiong , Chen Chen
Published: February 2025

Background

Since 2012, China has had one degreed undergraduate programme in global health for domestic students. The International Health Project Management course is a core component of this programme’s curriculum, bridging theoretical knowledge to practice in global health engagement. This study aims to evaluate whether introducing a teamwork and role-play module would meet the learning objectives, including improving students’ perception of global health, enhancing their understanding of the management processes for global health projects, and eventually developing competencies for effective global health involvement.

Methods

The teamwork role-play module was used in a scenario assuming that all students played a specific role in project management in the ‘Health System Enhancement for Pandemic Preparedness in Southeast and South Asian Countries’ programme. This programme called for proposals to implement a project in at least one country in Southeast or South Asia. We conducted a content analysis using two types of materials from the students: (1) concept note and proposal presentations and (2) students’ responses to the open-question feedback survey with four questions.

Results

Students addressed the colonial origins of global health and its evolving definition, emphasising the need for a broader interdisciplinary approach. They perceived China’s role in global health as evolving from a recipient to a donor, collaborator or participator, with a focus on enhancing soft power. However, their inadequate background knowledge of global health issues hindered their ability to undertake the tasks in depth. Students provided positive feedback on the teamwork with the role-play module, highlighting improved efficiency, broader and deeper learning through communication, increased participation, etc. Challenges such as poor leadership in teamwork, communication breakdowns and unequal workload distribution were identified.

Conclusions

Students showed a comprehensive understanding of managing a global health project through their teamwork tasks. Introducing teaching assistants to support teamwork, providing more hands-on opportunities, and integrating a broader range of disciplines into the curriculum will be crucial for the continued development of effective global health education programmes.
Efficacy of a 4-week yoga module on the sympatho-vagal balance among healthcare workers in a tertiary care hospital: a randomised controlled trial
Authors: Verma Anita , Saxena Vartika , Goyal Bela , Saoji Apar Avinash , Saxena Yogesh
Published: February 2025

Healthcare workers (HCWs) actively involved in patient care at tertiary care hospitals face significant stress and workload, which may adversely impact their sympatho-vagal balance (SVB). Research has extensively investigated SVB using various techniques, such as heart rate variability (HRV). With its multifaceted approach, yoga has been suggested to influence autonomic nervous system function and, consequently, SVB. Thus, this study aims to investigate the efficacy of a 4-week yoga module on SVB among HCWs. This randomised controlled trial will involve 108 HCWs aged 19–60 years. Participants will be randomised to either (1) a yoga intervention group or (2) a medium-paced walking control group. The primary outcome is a change in HRV after 4 weeks of intervention. Secondary outcomes comprise immediate change in state anxiety, selective attention and HRV compared pre- and post-intervention on days 1, 14 and 28. Intention-to-treat and per-protocol analysis will be performed to gain a comprehensive understanding of the effects of intervention. Multivariate linear model will adjust covariates in baseline HRV data in both groups. Independent t-test will compare pre- and postdata on all outcomes between groups. Paired t-test will be used to compare pre- and postdata on all outcomes within the group. The study protocol is registered on the Clinical Trials Registry – India (CTRI) (CTRI/2024/09/074132).
Relationship of long-term air pollution exposure with chronic obstructive pulmonary disease: an Italian multicentre observational study
Authors: Maio Sara , Fasola Salvatore , Marcon Alessandro , Angino Anna , Baldacci Sandra , Bilò Maria Beatrice , Bono Roberto , Fois Alessandro Giuseppe , La Grutta Stefania , Marchetti Pierpaolo , Sarno Giuseppe , Squillacioti Giulia , Stanisci Ilaria , Pirina Pietro , Tagliaferro Sofia , Verlato Giuseppe , Villani Simona , Gariazzo Claudio , Stafoggia Massimo , Viegi Giovanni
Published: February 2025

Background

Recent evidence showed that 50% of chronic obstructive pulmonary disease (COPD) may be attributable to air pollution. We aimed to investigate the association between long-term air pollution exposure and COPD symptoms/diagnosis in an Italian epidemiological study.

Methods

A total of 14 420 adults living in Ancona, Pavia, Pisa, Sassari, Turin and Verona were investigated in 2005–2011. Data on risk factors and health outcomes were collected by questionnaires; mean annual concentrations of particulate matters (PM) like PM10and PM2.5as well as NO2and mean summer concentrations of O3(µg/m3) at residential level with a 1 km resolution (period 2013–2015) were obtained by machine learning techniques. The relationship of pollutant exposure and COPD prevalence was assessed by logistic regression models (single pollutant) and principal component logistic regression models (multipollutant) adjusting for sex, age, education level, smoking habits, season of interview, and city-specific climatic index and including a random intercept for cohorts.

Results

A 10 µg/m3increase of PM10, PM2.5and NO2exposure was related to COPD diagnosis and symptoms (OR 1.31, 95% CI 1.03 to 1.65 for PM2.5; OR 1.26, 95% CI 1.03 to 1.54 for PM10and OR 1.07, 95% CI 1.00 to 1.15 for NO2) using a multipollutant approach. Similar results emerged for dyspnoea (OR 1.24, 95% CI 1.05 to 1.47 for PM2.5; OR 1.21, 95% CI 1.05 to 1.39 for PM10and OR 1.06, 95% CI 1.01 to 1.11 for NO2). Associations between COPD symptoms and summer O3were less clear. By multipollutant models, OR estimates were lower than those by single pollutant models.

Conclusions

Further evidence about the relationship between air pollution and respiratory effects in Italian adults was provided indicating PM as the main driver.
Clinical implication of regional osteopenia in complex regional pain syndrome: a retrospective comparative study
Authors: Kim Jeongsoo , Rho Hyungsang , Yoo Yongjae , Cha Joon , Park Sunghoon , Kim Hangaram , Omar Sanihah Che , Moon Jee Youn
Published: February 2025

Background

Despite the significant role of impaired bone metabolism in complex regional pain syndrome (CRPS), the clinical implications of osteopenia remain a focal point of investigation. We examined the prevalence and risk factors of affected limb osteopenia in CRPS and its association with the response to sympathetic blockade.

Methods

167 patients with CRPS who underwent CT of their affected limbs were retrospectively reviewed. After conducting univariable analyses where regional osteopenia determined by CT was dependent and other clinical factors were independent variables, the first multivariable analysis assessed risk predictors associated with regional osteopenia in CRPS. Next, after conducting univariable analyses where sympathetic block response was dependent and others, including regional osteopenia, were independent variables, the second multivariable model predicted factors associated with the response to sympathetic blockades, followed by receiver operating characteristic curve analysis.

Results

Among 116 patients, regional osteopenia was identified in 72.2% early (<1 year) and 52.5% persistent CRPS. In the first multivariable analysis adjusted for age, sex, body mass index (BMI), and other variables with p values<0.1 from initial univariable analyses, older age (OR 1.06; 95% CI 1.02 to 1.10) and positive three-phase bone scintigraphy (TPBS) (OR 3.94; 95% CI 1.46 to 10.66) were significantly associated with regional osteopenia. In the second multivariable model adjusted for age, sex, BMI, and other variables with p values<0.1 from univariable analyses, early phase (OR 5.49; 95% CI 1.44 to 20.88), regional osteopenia (OR 5.11; 95% CI 1.49 to 17.53), and positive TPBS (OR 6.30; 95% CI 2.21 to 17.93) were significantly associated with positive responses to sympathetic blockade in CRPS, showing excellent performance characteristics with a predicted probability>0.358 (sensitivity 0.86; specificity 0.76).

Conclusion

Regional osteopenia in the affected limb can anticipate positive responses to sympathetic blockade when combined with TPBS in early CRPS.
Associations between baseline pain, depressive symptoms, and unpaid caregiving needs and 1-year postdischarge outcomes among seriously ill older adults admitted for trauma
Authors: Dhanani Hiba , Wang Yihan , Bollens-Lund Evan , Reich Amanda , Wong Jolene , Ankuda Claire , Lipsitz Stuart , Gray Tamryn , Kim Dae Hyun , Ritchie Christine , Cooper Zara
Published: February 2025

Background

Many older adults with trauma have pre-existing serious illness like dementia, frailty, and organ insufficiency and are candidates for palliative care to improve outcomes and reduce downstream healthcare utilization. We hypothesize that baseline pain, depressive symptoms, and unpaid caregiving needs are associated with increased healthcare utilization in the year after trauma admission in seriously ill older adults.

Methods

Using the Health and Retirement Study (2008–2018) linked to Medicare claims, we identified adults aged ≥66 years admitted for trauma. We assessed pre-admission pain (none/mild vs moderate/severe), depressive symptoms (no—Center for Epidemiologic Studies Depression Scale (CES-D) <3 vs yes—CES-D ≥3) and unpaid caregiving needs (none vs any); and hospital characteristics: trauma center designation and palliative care service. The χ2tests were used for categorical variables, and t-tests were used for continuous variables. Associations of pain, depressive symptoms, unpaid caregiving needs with healthcare utilization were tested with negative binomial and Poisson regression models.

Results

Among 1693 older adults with serious illness, a third (35.7%) were older than 85 years, two-thirds were female (67.5%), and almost all were White (88.7%). Before trauma, 36.4% reported moderate/severe pain, 40.2% reported depressive symptoms (CES-D >3), and 34.9% reported any amount of hours/week of unpaid caregiving needs. Adjusted analyses demonstrated that compared with those without depressive symptoms, seriously ill older adults with depressive symptoms were less likely to be alive (incidence rate ratio (IRR) 0.61, 95% CI 0.41 to 0.91), had more emergency room visits (IRR 1.62, 95% CI 1.15 to 2.27), and more hospital visits (IRR 1.48, 95% CI 1.08 to 2.03) in the year after admission. Adjusted analyses of association of pain and caregiving with healthcare utilization were not significant.

Conclusions

Seriously ill older trauma patients with depressive symptoms have increased healthcare utilization in the year after discharge. Palliative care interventions may improve patient outcomes and reduce postdischarge healthcare utilization.

Level of evidence

III.
The
Ureocrinus bockschii
bed of Trearne Quarry SSSI (Mississippian, Lower Carboniferous), north Ayrshire, Scotland
Authors: Hoare Gary , Donovan Stephen K.
Published: February 2025

Trearne Quarry in north Ayrshire, south-west Scotland, is a Brigantian (Mississippian) age Site of Special Scientific Interest (SSSI) with a diverse marine biota. The crinoids are notable, many species being known from well-preserved cups and columns showing pitted infestations. The horizon considered herein is named, informally, the
Ureocrinus bockschii
bed. The named species is a dendrocrinidea cladid that is the most common species from this site. The calyx seems to have had an inherent robustness as they are more common than any other crinoid species. The
U. bockschii
bed yields only rare disarticulated calyx plates of other crinoid species. Pits,
Oichnus simplex
Bromley, in stems are more likely to be domiciles of unmineralized infesting organisms rather than evidence for gastropod parasitism or predation. Crinoid attachment structures are rare. The associated fauna is limited, including brachiopods, corals (
Othoceras
sp.), bryozoans (
Rhabdomeson
sp.), the bellerophontid
Euphemites urii
(Fleming) and rare fishes,
Petalodus acuminatus
(Agassiz).
Comparative Evaluation of GPT Models in FHIR Proficiency
Authors: Pope Tia , Patooghy Ahmad
Published: February 2025

Ensuring interoperability in healthcare data exchange is vital for advancing patient care, and Fast Healthcare Interoperability Resources (FHIR®) has emerged as a cornerstone standard in this effort. As healthcare increasingly integrates AI for managing and interpreting complex data, proficiency in FHIR is essential to ensure seamless and reliable interactions with healthcare systems. This study evaluates the FHIR proficiency of Generative Pre-trained Transformer (GPT) models, which serves as a critical benchmark for applying artificial intelligence (AI) in healthcare. The performance of GPT-3.5, GPT-4.0, and two custom models was assessed in two FHIR examination scenarios using novel metrics, including Token Processing Cost (TPC), Accuracy-Adjusted Token Processing Cost (ATPC), Comprehensive Performance Index (CPI), and Quality-Adjusted Performance Score (QAPS). GPT-4.0 demonstrated superior accuracy and robustness, while custom models such as the “FHIR Interop Expert” showed strengths in domain-specific tasks through effective prompt engineering. Despite these capabilities, none of the models consistently achieved the

\(\geq 99\)

% accuracy required for high-stakes healthcare applications. The findings underscore the importance of refining domain-specific training and evaluation methods. The proposed metrics provide a replicable framework for assessing AI readiness, offering a foundation for the responsible and effective integration of AI into healthcare workflows.
The Effect of Stress Ball Utilization on Dyspnea Severity and Anxiety Level in Patients Receiving Nebulizer Therapy: Randomized Controlled Study
Authors: Ceyhan Yasemin , Güler Sevil , Şahan Seda
Published: February 2025

Aim: The study primarily aimed at examining the effect of stress ball utilization on dyspnea and anxiety during nebulizer therapy. The secondary aim was to determine the effect of stress ball utilization on the duration of therapy and vital signs.

Methods: The study has a randomized controlled experimental design. The study population consisted of inpatients receiving nebulizer therapy. A total of 80 patients, 40 in the intervention group and 40 in the control group, were included in the sample. The study was conducted between October 2023 and March 2024. Patients in the intervention group were asked to use a stress ball during nebulizer therapy. Data were collected using a Patient Information Form, the Visual Analog Scale, and the State‐Trait Anxiety Inventory. Descriptive statistics, Chi‐square, paired test, and one sample t‐test were used in data analysis.

Results: The mean age of the patients was 65 years and over and 78% of them had COPD. Stress ball utilization caused a significant effect on the severity of dyspnea (intervention: t = 2.862, p <  0.001; control: t = 2.755, p < 0.001) and anxiety levels (intervention: t = 4.647, p < 0.001; control: t = 6.597, p < 0.001) in intragroup comparisons. In intergroup comparisons, a significant difference (tı = 4.455, p < 0.001) was obtained in anxiety level with a high effect (d = 0.70). In addition, the durations of nebulizer (minutes) administration were significantly (p < 0.001) longer in the intervention group (19.10 ± 11.95) than in the control group (13.16 ± 3.02). Stress ball utilization did not affect vital signs and saturation values (p > 0.05).

Conclusions: Utilization of a stress ball during nebulizer therapy has a positive effect on reducing anxiety levels and prolonging the duration of nebulizer use.

Trial Registration: ClinicalTrials.gov identifier: NCT06297356
Profiles and Influencing Factors of Work–Family Balance Among Nurses in China: A Cross‐Sectional Study Based on Latent Profile Analysis
Authors: Tang Qian , Wang Yijia , Zhang Chi , Zhao Yuefan , Zhou Xinjie , Huang Jie , Yao Jun
Published: February 2025

Aim: To profile the work–family balance (WFB) among clinical nurses and identify their influencing factors.

Background: WFBs take on various patterns in nurses. Nurses with different characteristics exhibit various patterns of WFB.

Methods: A cross‐sectional study was performed, involving 1292 nurses from public hospitals in Jiangsu Province from February to April 2024. Latent profile analysis (LPA) was employed to categorize the data, and multinominal logistic regression analysis to determine factors influencing WFB.

Results: A total of 1718 questionnaires were distributed, yielding 1292 valid responses (a response rate of 75.2%). The total score of WFB was 44.35 ± 8.693 points. The LPA revealed three profiles of WFB: the family priority group (28.1%), the balanced adaptation group (46.8%), and the challenge coping group (25.1%). The entropy value was high (0.892), indicating a correct classification. Multivariate regression analyses showed that professional title, department, nonclinical work pressure, organizational identification, work meaning, and self‐efficacy as factors influencing WFB profiles.

Conclusion: The WFB among nurses was at a moderate level with significant heterogeneity and could be divided into three profiles. The challenge coping group presented lower professional titles and higher self‐efficacy, and working at surgical, pediatric, and other specialized departments. Managers can tailor intervention strategies based on the characteristics and influencing factors of each profile.

Implications for Nursing Management: Nursing managers must consider the characteristics of high‐risk groups and factors that affect WFB and take targeted measures to mitigate work–family conflicts (WFC) among nurses and stabilize the nursing workforce.
Mindful Self‐Care and Compassion Fatigue in Nurses: The Chain Mediating Roles of Resilience and Professional Identity
Authors: Wei Junfan , Yun Zhengcheng , Zhang Yang , Liang Yongqi , Hu Ziping , Gao Chanchan , Tang Xiaona , Liu Hanjiao
Published: February 2025

Aim: To investigate the relationship between mindful self‐care and compassion fatigue and the chain mediating effects of resilience and professional identity.

Background: Compassion is a critical quality for nurses, but they often face the risk of compassion fatigue.

Methods: From October 2023 to May 2024, a cross‐sectional survey was conducted in six tertiary hospitals in Guangdong, Henan, and Jiangsu provinces by convenience sampling. A total of 1315 clinical nurses in the hospital were surveyed using the Social–demographic Characteristics Questionnaire, the Chinese Version of the Brief Mindful Self‐Care Scale, the Chinese Version of the Connor–Davidson Resilience Scale, the Professional Identity Scale for Nurses, and the Chinese Version of the Compassion Fatigue Short Scale. The mediation model was analyzed using a bias‐corrected bootstrapping method with PROCESS 4.1 implemented in SPSS 26.0.

Results: Pearson correlation analysis showed that there was a positive correlation between nurses’ mindful self‐care, resilience, and professional identity. Mindful self‐care, resilience, and professional identity were negatively correlated with compassion fatigue. Resilience played a partial mediating role between mindful self‐care and compassion fatigue. Professional identity also played a partial mediating role between mindful self‐care and compassion fatigue; mindful self‐care affected compassion fatigue through resilience and professional identity.

Conclusion: Nurses’ mindful self‐care can affect compassion fatigue through the mediating role of resilience and professional identity. In the future, attention should be paid to cultivating nurses’ mindful self‐care ability and resilience and improving nurses’ professional identity, which may help to reduce nurses’ compassion fatigue.
Supplementary Dataset 1 from Energy Stress–Induced circEPB41(2) Promotes Lipogenesis in Hepatocellular Carcinoma
Authors: Yang Yang , Luo Jingjing , Wang Zhongyu , Liu Kaiyue , Feng Keyi , Wang Fang , Mei Yide
Published: February 2025

The information of tissue samples from 73 liver cancer patients.
Table S1 from Breast Cancer Subtype–Specific Organotropism Is Dictated by FOXF2-Regulated Metastatic Dormancy and Recovery
Authors: Jiang Wen-Jing , Zhou Tian-Hao , Huang Huan-Jing , Li Lin-Sen , Tan Hao , Zhang Rui , Wang Qing-Shan , Feng Yu-Mei
Published: February 2025

Supplementary Table 1
Figure S7 from Breast Cancer Subtype–Specific Organotropism Is Dictated by FOXF2-Regulated Metastatic Dormancy and Recovery
Authors: Jiang Wen-Jing , Zhou Tian-Hao , Huang Huan-Jing , Li Lin-Sen , Tan Hao , Zhang Rui , Wang Qing-Shan , Feng Yu-Mei
Published: February 2025

Supplementary Figure 7
Figure S6 from Breast Cancer Subtype–Specific Organotropism Is Dictated by FOXF2-Regulated Metastatic Dormancy and Recovery
Authors: Jiang Wen-Jing , Zhou Tian-Hao , Huang Huan-Jing , Li Lin-Sen , Tan Hao , Zhang Rui , Wang Qing-Shan , Feng Yu-Mei
Published: February 2025

Supplementary Figure 6
Figure S3 from Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific Heterogeneity
Authors: Nie Jianhua , Zhang Shuyuan , Guo Ying , Liu Caiqi , Shi Jiaqi , Wu Haotian , Na Ruisi , Liang Yingjian , Yu Shan , Quan Fei , Liu Kun , Li Mingwei , Zhou Meng , Zhao Ying , Li Xuehan , Luo Shengnan , Zhang Qian , Wang Guangyu , Zhang Yanqiao , Yao Yuanfei , Xiao Yun , Tai Sheng , Zheng Tongsen
Published: February 2025

Interactions between T cell clusters in BTC.
Figure S1 from Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific Heterogeneity
Authors: Nie Jianhua , Zhang Shuyuan , Guo Ying , Liu Caiqi , Shi Jiaqi , Wu Haotian , Na Ruisi , Liang Yingjian , Yu Shan , Quan Fei , Liu Kun , Li Mingwei , Zhou Meng , Zhao Ying , Li Xuehan , Luo Shengnan , Zhang Qian , Wang Guangyu , Zhang Yanqiao , Yao Yuanfei , Xiao Yun , Tai Sheng , Zheng Tongsen
Published: February 2025

Identification of 27 T cell clusters in BTC at single-cell resolution.
Supplementary Figure S5 from HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma
Authors: Yamamoto Naomi , Dobersch Stephanie , Loveless Ian , Samraj Annie N. , Jang Gun Ho , Haraguchi Miki , Kang Liang-I. , Ruzinova Marianna B. , Vij Kiran R. , Mudd Jacqueline L. , Walsh Thomas , Safyan Rachael A. , Chiorean Elena Gabriela , Hingorani Sunil R. , Bolton Nathan M. , Li Li , Fields Ryan C. , DeNardo David G. , Notta Faiyaz , Crawford Howard C. , Steele Nina G. , Kugel Sita
Published: February 2025

Supplementary Figure S5. Representative CD8+ and FAP+ scoring. CD8 (top) and FAP (bottom) were scored on a scale of 0 (least staining) to 3 (most staining) following the representative scale.
Supplementary Figure S2 from HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma
Authors: Yamamoto Naomi , Dobersch Stephanie , Loveless Ian , Samraj Annie N. , Jang Gun Ho , Haraguchi Miki , Kang Liang-I. , Ruzinova Marianna B. , Vij Kiran R. , Mudd Jacqueline L. , Walsh Thomas , Safyan Rachael A. , Chiorean Elena Gabriela , Hingorani Sunil R. , Bolton Nathan M. , Li Li , Fields Ryan C. , DeNardo David G. , Notta Faiyaz , Crawford Howard C. , Steele Nina G. , Kugel Sita
Published: February 2025

Supplementary Figure S2. Demographic data for analyzed cohort. A) Age distribution for TMA and Ochsner cohorts. B) Race distribution for TMA and Ochsner cohorts. C) Proportions of disease by stage (left) and resulting survival (right) predicts survival in TMA cohort (AJCC 8th edition).
Supplementary Table S2 from Genomic Profiling Reveals SMARCA4 Mutations Are Associated with Shorter Overall and Intracranial Progression-Free Survival in Patients with Melanoma Brain Metastases
Authors: Fischer Grant M. , Lamba Nayan , Vogelzang Jayne , Aizer Ayal , Ligon Keith L.
Published: February 2025

Supplementary Table S2. Clinical information for all main cohort of melanoma brain metastasis samples included in analyses.
Supplemental Table 1 from Duvelisib with Docetaxel for Patients with Anti–PD-1 Refractory, Recurrent, or Metastatic Head and Neck Squamous Cell Carcinoma
Authors: Hanna Glenn J. , Oakley L. B. , Shi R. , ONeill A. , Shin K. Y. , Scarfo N. , Sehgal K. , Dennis M. J. , Quinn N. , Jo V. Y. , Wong K. , Shvyrkova A. , Kushnarev V. , Shanthappa B. U. , Tkachuk A. , Kryukov K. , Sarachakov A. , Svekolkin V. , Lennerz J. , Waters S. , Haddad R. I.
Published: February 2025

Supplemental Table 1. Overview of the multiplex immunofluorescence panel.
Supplementary Table 4 from A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
Authors: Livingston J. Andrew , Blay Jean-Yves , Trent Jonathan , Valverde Claudia , Agulnik Mark , Gounder Mrinal , Le Cesne Axel , McKean Meredith , Wagner Michael J. , Stacchiotti Silvia , Agresta Samuel , Quintás-Cardama Alfonso , Reilly Sarah A. , Healy Kathleen , Hickman Denice , Zhao Tina , Ballesteros-Perez Alex , Khalil Alexis , Collins Michael P. , Piel Jessica , Horrigan Kim , Lefkovith Ariel , Innis Scott , Lazar Alexander J. , Cote Gregory M. , Wagner Andrew J.
Published: February 2025

Supplementary Table 4