bluuebunny/crossref_metadata_2025 huggingface dataset:
Complexity of non-abelian cut-and-project sets of polytopal type I: special homogeneous Lie groups
Authors: KAISER PETER
Published: May 2024

The aim of this paper is to determine the asymptotic growth rate of the complexity function of cut-and-project sets in the non-abelian case. In the case of model sets of polytopal type in homogeneous two-step nilpotent Lie groups, we can establish that the complexity function asymptotically behaves like

$r^{{\mathrm {homdim}}(G) \dim (H)}$

. Further, we generalize the concept of acceptance domains to locally compact second countable groups.
Characterizing the clinical and sociodemographic profiles of hospitalized adolescents with autism spectrum disorder
Authors: Avrahami Matan , Ben-Dor David Haim , Ratzon Roy , Weizman Abraham , Perlman Danieli Polina
Published: May 2024

The prevalence of autism spectrum disorder (ASD) is increasing worldwide. Youngsters with ASD demonstrate higher rates of intellectual disabilities (IDs), comorbid psychopathology and psychiatric hospitalizations, compared to children in the general population. This study characterizes the demographics and clinical parameters of adolescent psychiatric inpatients with ASD compared to inpatients without ASD, all hospitalized during the study period. Additionally, within the ASD group, those with ID were compared to those without. The rate of males among participants with ASD was significantly higher than among those without ASD, and the duration of hospitalization was longer. In contrast, the rate of cigarette smoking, major depressive disorder and suicidal thoughts among those with ASD was lower. One-third of those with ASD had moderate to severe ID, about 10% had comorbid epilepsy, and about half of them demonstrated aggressive behavior. Most ASD patients showed significant improvement upon discharge, although the extent of improvement was more prominent among ASD patients with no ID. Our findings, consistent with previous research, indicate that hospitalization is beneficial to youths with ASD, both those with and those without ID. Further studies that include long-term follow-up are needed.
Impact of a national audit on child and adolescent psychiatrists’ prescribing practices
Authors: Bond L. , Ong J. Z. , McNicholas F.
Published: May 2024

Background:

A look back review of South Kerry Child and Adolescent Mental Health Services (CAMHS) in Ireland, known as the ‘Maskey report’ (MR), highlighted substandard prescribing practices. The aim of this ‘Maskey Impact Study’ (MIS) was to explore changes to child and adolescent psychiatrists’ prescribing practices following the MR.

Method:

The study was cross-sectional and mixed method. A study specific questionnaire was distributed electronically to psychiatrists working in CAMHS (n = 160).

Results:

102 psychiatrists participated in the study (response rate 63.8%). Perceived improvement in prescribing practices included improved medical record keeping (63.7%), consent documentation (53.9%), medication information provision (41.2%) and physical health monitoring (60.8%). However, 43.1% of psychiatrists reported a reluctance to prescribe medication even when clinically indicated and 50% were more likely to avoid off-label use. Most respondents reported increased stress levels (80.4%) with higher stress being significantly associated with reticence in prescribing (χ2 = 11.746, p < .001) and avoiding off-label use (χ2 = 15.392, p < 0.001). Thematic analysis highlighted increased medication hesitancy, enforced ‘meaningless’ bureaucracy and medication mistrust among families.

Discussion:

Although improvements reported are welcomed, the increased hesitancy of medication use, avoidance of prescribing more than one medication, and avoidance of off-label use, is of concern with potential unintended adverse consequences. Reluctance in prescribing may deprive youth of access to evidence-based treatments and limit exposure of NCHDs to the safe practice of consultant-initiated psychopharmacology. Further research will be important to determine if this impacts clinical care. Continued education in psychopharmacology is essential along with increased public awareness of the evidence for medication, to help restore public confidence and trust in psychopharmacology.
On the use of the Astarita flow field for viscoelastic fluids to develop a generalised Newtonian fluid model incorporating flow type (GNFFTy)
Authors: Poole R.J.
Published: May 2024

The two-dimensional, steady, homogeneous flow field proposed by Astarita (J. Rheol., vol. 35, 1991, pp. 687–689) is studied for a range of viscoelastic constitutive equations of differential form including the models due to Oldroyd (the upper and lower convected Maxwell; UCM/LCM), Phan-Thien and Tanner (simplified, linear form; sPTT) and Giesekus. As the flow is steady and homogeneous, the sPTT model results also give the FENE-P model solutions via a simple transformation of parameters. The flow field has the interesting feature that a scalar parameter may be used to vary the flow ‘type’ continuously from solid-body rotation to simple shearing to planar extension whilst the rate of deformation tensor

$\boldsymbol{\mathsf{D}}$

remains constant (i.e. independent of flow type). The response of the models is probed in order to determine how a scalar ‘viscosity’ function may be rigorously constructed which includes flow-type dependence. We show that for most of these models – the Giesekus being the exception – the first and second invariants of the resulting extra stress tensor are linearly related, and for models based on the upper convected derivative, this link is simply via a material property, i.e. half the modulus. By defining a frame-invariant coordinate system with respect to the eigenvectors of

$\boldsymbol{\mathsf{D}}$

, we associate a ‘viscosity’ for each of the flows to a deviatoric stress component and show how this quantity varies with the flow-type parameter. For elliptical motions, rate thinning is always observed and all models give essentially the UCM response. For strong flows, i.e. flow types containing at least some extension, thickening occurs and only a small element of extension is required to remove any shear thinning inherent in the model (e.g. as occurs in steady simple shearing for the sPTT/Giesekus models). Finally, a functional form of a viscosity equation which could incorporate flow type, but be otherwise inelastic, the so-called GNFFTy (generalised Newtonian fluid model incorporating flow type, pronounced ‘nifty’), is proposed. In the frame-invariant coordinate system proposed, this model is also capable of capturing normal-stress differences.
The evidential challenge for petitionary prayer
Authors: Oren Noam
Published: May 2024

In the past decade, philosophers have devoted a great deal of attention to the practice of petitionary prayer. Philosophical inquiries have posed a priori problems – issues that arise from an analytical investigation of the concept of God, the concept of petitionary prayer, and the relationship between the two. Taking a different direction, this article shifts the focus from possibility to actuality. Accordingly, this article does not deal with the question ‘Can God answer petitionary prayers?’ but rather with the question ‘Does God answer petitionary prayers?’ and, mainly, its implications. More accurately, I will present the tension between the religious belief that petitionary prayers can be effective and the fact that this does not seem to be so in reality, a claim that has been the conclusion of several empirical studies. Then I will present and examine several solutions to this tension. Although I will try to promote my preferred solution, my main aim is to clarify the problem and discuss the advantages and disadvantages of the solutions offered to solve the problem under discussion.
Divine command theory and the (supposed) incoherence of self-commanding
Authors: Resto Quiñones Jashiel
Published: May 2024

Theological voluntarism is a family of metaethical views that share the claim that deontological statuses of actions are dependent on or identical with some divine feature. Adams's version of this theistic metaethical view is a divine command theory (DCT). According to Adams's DCT, the property being-morally-obligated is identical to the property being-commanded-by-God. Thus, a natural consequence of Adams's DCT is that an agent is morally obligated to do something just in case God commands that agent to do such a thing. From Adams's DCT, it follows that God is morally obligated to act just in case God commands himself to act. Quinn argued that commanding oneself is incoherent and, therefore, that God cannot be morally obligated to act. The claim that commanding oneself is incoherent has seldom been discussed in the divine command theory literature. This article is an attempt to change that. Here, I argue (contra Quinn) that that no constitutive rule (or condition of satisfaction) of self-commands is incoherent, from which it follows that self-commanding is not an incoherent speech act. I conclude that divine command theorists can, without the charge of incoherence, affirm that God can be morally obligated because God can command himself.
Sceptical theism, divine commands, and love
Authors: Lee Ho-yeung
Published: May 2024

Sceptical theists respond to the problem of evil by arguing that we should be sceptical of our abilities to understand God's plan and the justifying reasons for his actions. A major difficulty faced by sceptical theism is the problem of moral paralysis. Some sceptical theists have proposed a divine command response: theists can appeal to God's commands in acting, and this circumvents the need to exercise value judgement in moral deliberations. This article provides an objection to the divine command response by arguing that it renders love impossible and practically undermines the possibility of the theistic way of life. As a result, this article demonstrates a constraint on any potential solution to the problem of moral paralysis in sceptical theism: the access to values of loving relationship and human well-being, as well as their role to play in agents’ deliberative process, should be safeguarded.
Changing the incentive structure of social media may reduce online proxy failure and proliferation of negativity
Authors: Robertson Claire E. , del Rosario Kareena , Rathje Steve , Van Bavel Jay J.
Published: May 2024

Social media takes advantage of people's predisposition to attend to threatening stimuli by promoting content in algorithms that capture attention. However, this content is often not what people expressly state they would like to see. We propose that social media companies should weigh users’ expressed preferences more heavily in algorithms. We propose modest changes to user interfaces that could reduce the abundance of threatening content in the online environment.
The cost of success or failure for proxy signals in ecological problems
Authors: Nonacs Peter
Published: May 2024

Two of John et al.'s examples of proxy failures in ecological situations are not failures: Runaway sexual selection and marsupial neonate competition. Instead, more appropriate ecological examples may be paternal genetic kin recognition and warning coloration. These differ in proxy effectiveness and failure in ways that illustrate the importance of “costs” in the evolution of ecological proxy traits.
Proxy failure in academia: More than just another example
Authors: Watve Milind
Published: May 2024

Proxy failure in academia has progressed much ahead of what John et al. describe. We see advanced phenomena such as proxy complimentarity in which different players push each others' proxy failures; proxy exploitation in which external agents exploit players' proxies and predatory proxies that devour the goal itself. Academics need to avoid proxy failures by designing behaviorally sound systems.
Teleonomy, legibility, and diversity: Do we need more “proxynomics”?
Authors: Braganza Oliver , John Yohan J. , Caldwell Leigh , McCoy Dakota E.
Published: May 2024

When a measure becomes a target, it ceases to be a good measure. (Strathern, 1997)

Our target article set out with an ambitious goal: To provide a unified account of the disparate descriptions of proxy failure across not only social and natural sciences but also engineering and artificial intelligence research. Clearly such a task could only truly be achieved by a broad transdisciplinary community. The wide range of commentaries from a remarkable array of disciplines has not only confirmed our main proposition – that the disparate cases do reflect the same core phenomenon of “proxy failure” – but suggests the viability of a new interdisciplinary undertaking that we might call “proxynomics.” Several comments highlighted key issues and extensions, others provided novel illuminating examples and, perhaps most importantly, quite a few proposed viable solutions or at least mitigation strategies.
What contributes to fluent L2 speech? Examining cognitive and utterance fluency link with underlying L2 collocational processing speed and accuracy
Authors: Takizawa Kotaro
Published: May 2024

Second language (L2) fluency research has suggested that a range of linguistic knowledge and processing speed serve as cognitive fluency (CF) underlying L2 utterance fluency (UF). Building on prior CF-UF link studies, this study explored L2 collocational processing speed and accuracy as underlying CF measures. This study also explored the phrasal frequency effect on the relationship between collocational processing speed and UF to test whether the processing speed of higher-frequency collocations is more strongly related to UF. A total of 108 Japanese university students completed a phrasal acceptability judgment task with adjective–noun collocations pooled from the Academic Collocation List. Speech was elicited in an argumentative speech task, and UF measures were computed based on speed, breakdown, and repair fluency. The results revealed that the collocational processing speed was weakly tied to articulation rate and mid-clause and end-clause silent pause ratio (rho= |.271–.322|), while the collocational processing accuracy was weakly to moderately tied to most UF measures except filled pause ratio (rho= |.281–.368|). The collocation frequency moderated the relationship between the processing speed and UF, suggesting that high-frequency collocations served as a proxy for automaticity in speech production. Implications for CF-UF link research are discussed.
No place to hide: The public attribution of responsibility for policy failures of international organisations
Authors: Zangl Bernhard , Heinkelmann-Wild Tim , Glovania Juliane , Klein-Bölting Louisa
Published: May 2024

Who is held responsible when international organisations (IOs) fall short of public expectations? Scholarship on IO blame avoidance assumes that member states can hide behind IOs. As clarity of responsibility is assumed to be lacking in IOs, public responsibility attributions (PRA) will usually target the IO rather than individual member states. We argue, by contrast, that even in complex IOs such as the European Union (EU), clarity of responsibility is not always lacking. Therefore, whether the IO in general or individual member states become the main target of public blame attributions depends on the type of IO policy failure. In cases of failures to act and failures to comply, the responsibility of individual member states is comparatively easy to identify, and they thus become the main blame target. Only in cases of failures to perform clarity of responsibility is lacking, and the IO will become the main target of public blame attributions. To assess the plausibility of this‘failure hypothesis’, we study public blame attributions in two cases of EU foreign policy failures and two cases of EU environmental policy failures.
Stylistic functions of anglicisms in German radio
Authors: Schaefer Sarah Josefine
Published: May 2024

Although English has no official status in countries of the expanding circle such as Germany (Kachru, 1985), English words and phrases, which are also referred to as anglicisms, can often be found in German mass media texts (Czech Rogoyska & Zboch, 2016; Fiedler, 2022; Glahn, 2002; Knospe, 2014; Onysko, 2004, 2007). In this context, previous research has paid much attention to the stylistic functions of anglicisms used by the mass media, often analysing brevity of expression and pragmatic functions of anglicisms, in particular how anglicisms are used to convey modernity (amongst others Piller, 2001; Winter–Froemel, Onysko & Calude, 2014). While such studies are usually exclusively based on analyses of German media corpora, this article enhances the current discourse on the developments around stylistic functions of English in German media texts by providing some insights from a larger research project which investigates shaping factors on radio content production and radio journalists’ perspectives on the use of anglicisms in the newsroom. In line with the overall results of the larger project, the analysis presented in this paper provides a brief overview of selected interview statements by adult contemporary radio journalists on whether anglicisms are used for reasons of brevity of expression and on their attitudes towards the use of English for conveying modernity on radio. The format of adult contemporary radio in Germany, in particular, has had a strong connection to the English language and Anglo-American culture from its very beginning, which makes it a prime example for such an analysis.
Deliberative process of health technology reassessment by health technology assessment agency in Korea
Authors: Shin Sangjin , Kim Yunjung , Choi Jieun , Park Jung Yul
Published: May 2024

In 2019, the National Evidence-based Healthcare Collaborating Agency (NECA) in Korea established a health technology reassessment (HTR) system to manage the life cycle of health technologies and develop operational measures promoting the efficient use of healthcare resources. The purpose of this study is to introduce the detailed implementation process and practical functional methods of the HTR implemented by NECA.

The HTR is a structured multidisciplinary method for analyzing health technologies currently used in the healthcare system based on the latest information on parameters, such as clinical safety, effectiveness, and cost-effectiveness of optimizing the use of healthcare resources as well as social and ethical issues. All decision-making stages of the HTR are carefully reviewed and transparently managed. The HTR committee makes significant decisions, and the subcommittee decides the details related to the assessment process.

Since the pilot began in 2018, 262 cases have been reassessed, of which, 126 cases (48.1 percent) were health services not covered by the National Health Insurance (NHI). Over the past 5 years, approximately 130 recommendations for the in-use technologies were determined by the HTR committee. In the near future, it will be necessary to officially develop and establish a Korean HTR system and a legal foundation to optimize the NHI system.
Witnesses for the State: Children and the Making of Modern Evidence Law
Authors: Savarese Laura
Published: May 2024

This article identifies an overlooked legacy of the child protection movement in the late-nineteenth and early-twentieth-century U.S.: transformations in evidence law and procedure that undermined common-law restrictions on children's testimony. Scholarship on the nineteenth-century modernization of evidence law argues that the rise of cross-examination allowed for the demise of common-law witness disqualification rules. The erosion of restrictions on children's testimony, however, requires an alternative or additional explanation, because cross-examination did not allay fears about children's reliability. The driving force for changes in the law governing child witnesses, I argue, was the slate of nineteenth-century child protection laws whose enforcement typically required children's testimony. The case study of Progressive-Era New York, presented here, reveals how evidence law and procedure adapted to substantive law's demand for children's evidence: reformers legislated an exception to the common-law oath requirement in children's cases, pushed trial courts to modernize their approach to examining child witnesses’ competency, and expanded the state's power to detain children as material witnesses. Those reforms fostered the ends of law enforcement, but did not resolve enduring debates about the reliability risks of children's testimony and the costs of testifying for children's wellbeing.
High all-cause mortality and increasing proportion of older adults with tuberculosis in Texas, 2008–2020
Authors: Medrano Belinda A. , Lee Miryoung , Gemeinhardt Gretchen , Yamba Lana , Restrepo Blanca I.
Published: May 2024

Pulmonary tuberculosis (PTB) elimination efforts must consider the global growth of the ageing population. Here we used TB surveillance data from Texas, United States (2008–2020; total n = 10656) to identify unique characteristics and outcomes in older adults (OA, ≥65 years) with PTB, compared to young adults (YA, 18–39 years) or middle-aged adults (40–64 years). We found that the proportion of OA with PTB increased from 15% in 2008 to 24% in 2020 (trend p < 0.05). Diabetes was highly prevalent in OA (32%) but not associated with adverse outcomes. Death was 13-fold higher in OA compared to YA and was 7% at the time of diagnosis which suggests diagnostic delays. However, once TB was suspected, we found no differences in culture, smear, or nucleic acid detection of mycobacteria (although less lung cavitations) in OA. During treatment, OA had less drug-resistant TB, few adverse reactions and adhered with TB treatment. We recommend training healthcare workers to ‘think TB’ in OA, for prompt treatment initiation to diminish deaths. Furthermore, OA should be added as a priority group to the latent TB treatment guidelines by the World Health Organization, to prevent TB disease in this highly vulnerable group.
Beyond Transformative Agreements: Ways Forward for Universities
Authors: Widding Astrid Söderbergh
Published: May 2024

This article deals with the transition to open access in Sweden, as part of the general transition to open science. Goals set by the Parliament and the government are discussed, as well as the strategies of the national Bibsam consortium, handling national deals with publishers, and of the Swedish Association of Higher Education Institutions. The development from the first stages in this process, where a main goal was to gain cost control, over a period with read-and-publish agreements to a situation where transformative agreements seem to tend to become permanent, is analysed. Finally, a number of possible scenarios for future developments are discussed, arguing for the need for university leadership to take an active part in the work towards a transition; it is not only an issue for individual researchers, or for librarians, but for the research community as a whole where universities are key players.
How To Get About
Authors: Sosa David
Published: May 2024

The ‘Only connect!’ that serves as epigraph to Forster's Howards End tolerates a variety of interpretations; but the very idea of a connection, or a relating of one thing with another, is conceptually deep. One form of connection is when something is about a thing, representing or symbolizing that thing. When we think of someone, or discuss something, we connect to them, or to it.

In his Philosophical Investigations, Wittgenstein asks, ‘What makes my image of him into an image of him? […] Isn't my question like this: “What makes this sentence a sentence that has to do with him?”’ Wittgenstein thus notes the ramifications of his question: what makes her name hers? In virtue of what is this thought about them a thought about them? The issue he highlights has been with us since Plato's Cratylus and its history is unified by a presupposition: whatever makes it that (i) a bit of language (like a name or a sentence or any linguistic symbol) is about something is, fundamentally, also what makes it that (ii) a thought (or idea or image) is about a thing. The story of aboutness will be uniform, simplex, or so the presupposition has it.

But the history of the issue has been one of failure: we still don't adequately understand the nature of representation. I will propose and develop a perspective that rejects the presupposition and explains the failure: there is more than one way for a thing to be about something. Representation comes, ultimately, in varieties.
A New Look at the Classical Chinese Dào of the Relation between Word and World
Authors: Hansen Chad
Published: May 2024

I argue that the absence of some of the ‘greatest hits’ of Western philosophy in Classical China can be explained by a Wittgensteinian take on the role of language in philosophy. One is the ‘Idea Theory’ of meaning which anchors Western Mind-Body dualism. Its attraction is removed when the writing reminds us that a picture does not by itself ‘give life to’ our language even while it plays a role of cross-linguistic communication. Another is the centrality of a law-command theory of normativity which combines with mind-body dualism to give a natural push toward monotheistic supernaturalism. Western attempts to make the ‘God’ impulse logical (e.g., the Ontological Argument) fail because of differences in Chinese syntax. The upshot is we need not deny Chinese thinkers the status of philosophers for their failure to share our philosophical presuppositions and resultant agenda.
Politics, Words, and Concepts: On the Impossibility and Undesirability of ‘Amelioration’
Authors: Antony Louise
Published: May 2024

Recently, several philosophers have argued that there is a political necessity to alter certain important concepts, such as WOMAN, in order to give us better tools to understand and change oppressive conditions. I argue that conceptual change of this sort is impossible. But I also argue that it is politically unnecessary – we can effect progressive change using the same old concepts we've always had.
DivFolio: a Shiny application for portfolio divestment in green finance wealth management
Authors: Marupanthorn Pasin , Peters Gareth W. , Ofosu-Hene Eric D. , Nikitopoulos Christina S. , Richards Kylie-Anne
Published: May 2024

This paper introduces DivFolio, a multiperiod portfolio selection and analytic software application that incorporates automated and user-determined divestment practices accommodating Environmental Social Governance (ESG) and portfolio carbon footprint considerations. This freely available portfolio analytics software tool is written in R with a GUI interface developed as an R Shiny application for ease of user experience. Users can utilize this software to dynamically assess the performance of asset selections from global equity, exchange-traded funds, exchange-traded notes, and depositary receipts markets over multiple time periods. This assessment is based on the impact of ESG investment and fossil-fuel divestment practices on portfolio behavior in terms of risk, return, stability, diversification, and climate mitigation credentials of associated investment decisions. We highlight two applications of DivFolio. The first revolves around using sector scanning to divest from a specialized portfolio featuring constituents of the FTSE 100. The second, rooted in actuarial considerations, focuses on divestment strategies informed by environmental risk assessments for mixed pension portfolios in the US and UK.
Investigating Fatigue in Operational Nightshifts
Authors: Peukert Maximilian , Sobotta Annika , Meyer Lothar
Published: May 2024

Abstract: The study investigated sleepiness and fatigue in a single split nightshift arrangement in air traffic control. The arrangement included two mirrored nightshift types, with sleep and operational phases alternating once mid-shift. Sleep duration, subjective sleepiness, and fatigue as well as sustained attention, which have not been thoroughly studied to date, were examined. The findings suggest different sleep strategies. Working during the second part of the night resulted in reduced sleep duration before the shift. Subjective fatigue exhibited varying patterns depending on the shift type and time, with elevated fatigue observed at the start and middle of the shift. However, subjective sleepiness and sustained attention were primarily influenced by the passage of time.
Geomagnetic Field Intensity During the First Millennium BCE From Royal Judean Storage Jars: Constraining the Duration of the Levantine Iron Age Anomaly
Authors: Hassul E. , Shaar R. , Vaknin Y. , Agnon A. , Gallet Y. , Leibner U. , Sabar R. , Freud L. , Sandhaus D. , Lipschits O.
Published: May 2024

The rich and extensively studied archaeological record of the Near East provides an opportunity to develop a comprehensive archaeomagnetic dataset for exploring the behavior of the geomagnetic field with high precision. The Levantine archaeomagnetic curve (LAC) project is an ongoing effort to develop a continuous high‐resolution geomagnetic intensity curve for the Levant and Mesopotamia. The first version of the LAC covered the period between 3000 and 550 BCE. Here, we report archaeointensity data from 169 samples compiled into 32 groups dating between the 7th and the 1st centuries BCE aiming at extending the LAC up to the end of the first millennium BCE. Twenty‐two groups are assembled from storage jar handles bearing different types of royal seal impressions, which were used in Judah as part of a taxation administrative system. These groups are combined with 10 other groups of pottery assemblages, three of which are from Hellenistic destruction layers dated using radiocarbon and coins. The new curve shows that the Levantine Iron Age Anomaly (LIAA) spanned 550 years (1100 ‐ 550 BCE) and that the rate of decline during the last spike around 600 BCE could have reached ∼0.6 μT/year. During the 6th century, the virtual axial dipole moment (VADM) dropped from 160 ZAm2 to 125 ZAm2 after which field intensity only slightly increased to 135 ZAm2, until another considerable decline to ∼90 ZAm2 during the 3rd to the 1st centuries BCE. We highlight the archaeomagnetic implication of the new curve in inferring the relative chronological relationship between different stamp types.
Whistler‐Mode Wave Generation During Interplanetary Shock Events in the Earth's Lunar Plasma Environment
Authors: Prasad Abhinav , Li Wen , Ma Qianli , Shen Xiao‐Chen
Published: May 2024

Whistler‐mode waves are commonly observed within the lunar environment, while their variations during Interplanetary (IP) shocks are not fully understood yet. In this paper, we analyze two IP shock events observed by Acceleration, Reconnection, Turbulence and Electrodynamics of the Moons Interaction with the Sun (ARTEMIS) satellites while the Moon was exposed to the solar wind. In the first event, ARTEMIS detected whistler‐mode wave intensification, accompanied by sharply increased hot electron flux and anisotropy across the shock ramp. The potential reflection or backscattering of electrons by the lunar crustal magnetic field is found to be favorable for whistler‐mode wave intensification. In the second event, a magnetic field line rotation around the shock region was observed and correlated with whistler‐mode wave intensification. The wave growth rates calculated using linear theory agree well with the observed wave spectra. Our study highlights the significance of magnetic field variations and anisotropic hot electron distributions in generating whistler‐mode waves in the lunar plasma environment following IP shock arrivals.
A cell-free nutrient-supplemented perfusate allows four-day ex vivo metabolic preservation of human kidneys
Authors: de Haan Marlon J. A. , Jacobs Marleen E. , Witjas Franca M. R. , de Graaf Annemarie M. A. , Sánchez-López Elena , Kostidis Sarantos , Giera Martin , Calderon Novoa Francisco , Chu Tunpang , Selzner Markus , Maanaoui Mehdi , de Vries Dorottya K. , Kers Jesper , Alwayn Ian P. J. , van Kooten Cees , Heijs Bram , Wang Gangqi , Engelse Marten A. , Rabelink Ton J.
Published: May 2024

The growing disparity between the demand for transplants and the available donor supply, coupled with an aging donor population and increasing prevalence of chronic diseases, highlights the urgent need for the development of platforms enabling reconditioning, repair, and regeneration of deceased donor organs. This necessitates the ability to preserve metabolically active kidneys ex vivo for days. However, current kidney normothermic machine perfusion (NMP) approaches allow metabolic preservation only for hours. Here we show that human kidneys discarded for transplantation can be preserved in a metabolically active state up to 4 days when perfused with a cell-free perfusate supplemented with TCA cycle intermediates at subnormothermia (25 °C). Using spatially resolved isotope tracing we demonstrate preserved metabolic fluxes in the kidney microenvironment up to Day 4 of perfusion. Beyond Day 4, significant changes were observed in renal cell populations through spatial lipidomics, and increases in injury markers such as LDH, NGAL and oxidized lipids. Finally, we demonstrate that perfused kidneys maintain functional parameters up to Day 4. Collectively, these findings provide evidence that this approach enables metabolic and functional preservation of human kidneys over multiple days, establishing a solid foundation for future clinical investigations.
Dynamic microvilli sculpt bristles at nanometric scale
Authors: Ikeda Kyojiro N. , Belevich Ilya , Zelaya-Lainez Luis , Orel Lukas , Füssl Josef , Gumulec Jaromír , Hellmich Christian , Jokitalo Eija , Raible Florian
Published: May 2024

Organisms generate shapes across size scales. Whereas patterning and morphogenesis of macroscopic tissues has been extensively studied, the principles underlying the formation of micrometric and submicrometric structures remain largely enigmatic. Individual cells of polychaete annelids, so-called chaetoblasts, are associated with the generation of chitinous bristles of highly stereotypic geometry. Here we show that bristle formation requires a chitin-producing enzyme specifically expressed in the chaetoblasts. Chaetoblasts exhibit dynamic cell surfaces with stereotypical patterns of actin-rich microvilli. These microvilli can be matched with internal and external structures of bristles reconstructed from serial block-face electron micrographs. Individual chitin teeth are deposited by microvilli in an extension-disassembly cycle resembling a biological 3D printer. Consistently, pharmacological interference with actin dynamics leads to defects in tooth formation. Our study reveals that both material and shape of bristles are encoded by the same cell, and that microvilli play a role in micro- to submicrometric sculpting of biomaterials.
LoCoHD: a metric for comparing local environments of proteins
Authors: Fazekas Zsolt , K. Menyhárd Dóra , Perczel András
Published: May 2024

Protein folds and the local environments they create can be compared using a variety of differently designed measures, such as the root mean squared deviation, the global distance test, the template modeling score or the local distance difference test. Although these measures have proven to be useful for a variety of tasks, each fails to fully incorporate the valuable chemical information inherent to atoms and residues, and considers these only partially and indirectly. Here, we develop the highly flexible local composition Hellinger distance (LoCoHD) metric, which is based on the chemical composition of local residue environments. Using LoCoHD, we analyze the chemical heterogeneity of amino acid environments and identify valines having the most conserved-, and arginines having the most variable chemical environments. We use LoCoHD to investigate structural ensembles, to evaluate critical assessment of structure prediction (CASP) competitors, to compare the results with the local distance difference test (lDDT) scoring system, and to evaluate a molecular dynamics simulation. We show that LoCoHD measurements provide unique information about protein structures that is distinct from, for example, those derived using the alignment-based RMSD metric, or the similarly distance matrix-based but alignment-free lDDT metric.
The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation
Authors: Wang Jun , Yang Qian , Liu Xue , Li Jie , Wen Ya-Lan , Hu Yuzheng , Xu Tian-Le , Duan Shumin , Xu Han
Published: May 2024

Elucidating the neural basis of fear allows for more effective treatments for maladaptive fear often observed in psychiatric disorders. Although the basal forebrain (BF) has an essential role in fear learning, its function in fear expression and the underlying neuronal and circuit substrates are much less understood. Here we report that BF glutamatergic neurons are robustly activated by social stimulus following social fear conditioning in male mice. And cell-type-specific inhibition of those excitatory neurons largely reduces social fear expression. At the circuit level, BF glutamatergic neurons make functional contacts with the lateral habenula (LHb) neurons and these connections are potentiated in conditioned mice. Moreover, optogenetic inhibition of BF-LHb glutamatergic pathway significantly reduces social fear responses. These data unravel an important function of the BF in fear expression via its glutamatergic projection onto the LHb, and suggest that selective targeting BF-LHb excitatory circuitry could alleviate maladaptive fear in relevant disorders.
Plasma electron acceleration driven by a long-wave-infrared laser
Authors: Zgadzaj R. , Welch J. , Cao Y. , Amorim L. D. , Cheng A. , Gaikwad A. , Iapozzutto P. , Kumar P. , Litvinenko V. N. , Petrushina I. , Samulyak R. , Vafaei-Najafabadi N. , Joshi C. , Zhang C. , Babzien M. , Fedurin M. , Kupfer R. , Kusche K. , Palmer M. A. , Pogorelsky I. V. , Polyanskiy M. N. , Swinson C. , Downer M. C.
Published: May 2024

Laser-driven plasma accelerators provide tabletop sources of relativistic electron bunches and femtosecond x-ray pulses, but usually require petawatt-class solid-state-laser pulses of wavelength λL ~ 1 μm. Longer-λL lasers can potentially accelerate higher-quality bunches, since they require less power to drive larger wakes in less dense plasma. Here, we report on a self-injecting plasma accelerator driven by a long-wave-infrared laser: a chirped-pulse-amplified CO2 laser (λL ≈ 10 μm). Through optical scattering experiments, we observed wakes that 4-ps CO2 pulses with <  1/2 terawatt (TW) peak power drove in hydrogen plasma of electron density down to 4 × 1017 cm−3 (1/100 atmospheric density) via a self-modulation (SM) instability. Shorter, more powerful CO2 pulses drove wakes in plasma down to 3 × 1016 cm−3 that captured and accelerated plasma electrons to relativistic energy. Collimated quasi-monoenergetic features in the electron output marked the onset of a transition from SM to bubble-regime acceleration, portending future higher-quality accelerators driven by yet shorter, more powerful pulses.
Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants
Authors: Grønbæk-Thygesen Martin , Voutsinos Vasileios , Johansson Kristoffer E. , Schulze Thea K. , Cagiada Matteo , Pedersen Line , Clausen Lene , Nariya Snehal , Powell Rachel L. , Stein Amelie , Fowler Douglas M. , Lindorff-Larsen Kresten , Hartmann-Petersen Rasmus
Published: May 2024

Unstable proteins are prone to form non-native interactions with other proteins and thereby may become toxic. To mitigate this, destabilized proteins are targeted by the protein quality control network. Here we present systematic studies of the cytosolic aspartoacylase, ASPA, where variants are linked to Canavan disease, a lethal neurological disorder. We determine the abundance of 6152 of the 6260 ( ~ 98%) possible single amino acid substitutions and nonsense ASPA variants in human cells. Most low abundance variants are degraded through the ubiquitin-proteasome pathway and become toxic upon prolonged expression. The data correlates with predicted changes in thermodynamic stability, evolutionary conservation, and separate disease-linked variants from benign variants. Mapping of degradation signals (degrons) shows that these are often buried and the C-terminal region functions as a degron. The data can be used to interpret Canavan disease variants and provide insight into the relationship between protein stability, degradation and cell fitness.
Multiline orthogonal scanning temporal focusing (mosTF) microscopy for scattering reduction in in vivo brain imaging
Authors: Xue Yi , Boivin Josiah R. , Wadduwage Dushan N. , Park Jong Kang , Nedivi Elly , So Peter T. C.
Published: May 2024

Temporal focusing two-photon microscopy has been utilized for high-resolution imaging of neuronal and synaptic structures across volumes spanning hundreds of microns in vivo. However, a limitation of temporal focusing is the rapid degradation of the signal-to-background ratio and resolution with increasing imaging depth. This degradation is due to scattered emission photons being widely distributed, resulting in a strong background. To overcome this challenge, we have developed multiline orthogonal scanning temporal focusing (mosTF) microscopy. mosTF captures a sequence of images at each scan location of the excitation line. A reconstruction algorithm then reassigns scattered photons back to their correct scan positions. We demonstrate the effectiveness of mosTF by acquiring neuronal images of mice in vivo. Our results show remarkable improvements in in vivo brain imaging with mosTF, while maintaining its speed advantage.
Analyzing Joshimath’s sinking: causes, consequences, and future prospects with remote sensing techniques
Authors: Awasthi Shubham , Jain Kamal , Sahoo Sashikanta , Kumar Rohit , Goswami Ajanta , Joshi Girish Chandra , Kulkarni Anil V. , Srivastava D. C.
Published: May 2024

The Himalayas are highly susceptible to various natural disasters, such as the tectonically induced land deformation, earthquakes, landslides, and extreme climatic events. Recently, the Joshimath town witnessed a significantly large land subsidence activity. The phenomenon resulted in the development of large cracks in roads and in over 868 civil structures, posing a significant risk to inhabitants and infrastructure of the area. This study uses a time-series synthetic aperture radar (SAR) interferometry-based PSInSAR approach to monitor land deformation utilizing multi-temporal Sentinel-1 datasets. The line of sight (LOS) land deformation velocity for the Joshimath region, calculated for the year 2022–2023 using a PSInSAR-based approach, varies from − 89.326 to + 94.46 mm/year. The + ve sign indicates the LOS velocity/displacement away from the SAR sensor, whereas − ve sign signifies the earth's movement towards the SAR sensor in the direction of LOS. In addition, the study investigates feature tracking land displacement analysis using multi-temporal high-resolution Planet datasets. The result of this analysis is consistent with the PSInSAR results. The study also estimated the land deformation for the periods 2016–2017, 2018–2019, and 2020–2021 separately. Our results show that the Joshimath region experienced the highest land deformation during the year 2022–2023. During this period, the maximum land subsidence was observed in the north-western part of the town. The maximum LOS land deformation velocity + 60.45 mm/year to + 94.46 mm/year (2022–2023), occurred around Singhdwar, whereas the north and central region of the Joshimath town experienced moderate to high subsidence of the order of + 10.45 mm/year to + 60.45 mm/year (2022–2023), whereas the south-west part experienced an expansion of the order of 84.65 mm/year to − 13.13 mm/year (2022–2023). Towards the south-east, the town experienced rapid land subsidence, − 13.13 mm/year to − 5 mm/year (2022–2023). The study analyzes the causative factors of the observed land deformation in the region. Furthermore, this work assesses the ground conditions of the Joshimath region using UAV datasets acquired in the most critically affected areas such as Singhdhaar, Hotel Mountain View, Malhari Hotel, and Manoharbagh. Finally, the study provides recommendations and future prospects for the development policies that need to be adopted in the critical Himalayan regions susceptible to land deformation. The study suggests that land deformation in the region is primarily attributed to uncontrolled anthropogenic activities, infrastructural development, along with inadequate drainage systems.
The Goldilocks principle of learning unitaries by interlacing fixed operators with programmable phase shifters on a photonic chip
Authors: Zelaya Kevin , Markowitz Matthew , Miri Mohammad-Ali
Published: May 2024

Programmable photonic integrated circuits represent an emerging technology that amalgamates photonics and electronics, paving the way for light-based information processing at high speeds and low power consumption. Programmable photonics provides a flexible platform that can be reconfigured to perform multiple tasks, thereby holding great promise for revolutionizing future optical networks and quantum computing systems. Over the past decade, there has been constant progress in developing several different architectures for realizing programmable photonic circuits that allow for realizing arbitrary discrete unitary operations with light. Here, we systematically investigate a general family of photonic circuits for realizing arbitrary unitaries based on a simple architecture that interlaces a fixed intervening layer with programmable phase shifter layers. We introduce a criterion for the intervening operator that guarantees the universality of this architecture for representing arbitrary $$N \times N$$

N
×
N

unitary operators with $$N+1$$

N
+
1

phase layers. We explore this criterion for different photonic components, including photonic waveguide lattices and meshes of directional couplers, which allows the identification of several families of photonic components that can serve as the intervening layers in the interlacing architecture. Our findings pave the way for efficiently designing and realizing novel families of programmable photonic integrated circuits for multipurpose analog information processing.
Pradimicin U, a promising antimicrobial agent isolated from a newly found Nonomuraea composti sp. nov
Authors: Duangupama Thitikorn , Pittayakhajonwut Pattama , Intaraudom Chakapong , Suriyachadkun Chanwit , Tadtong Sarin , Kuncharoen Nattakorn , He Ya-Wen , Tanasupawat Somboon , Thawai Chitti
Published: May 2024

Pradimicin U is a new dihydrobenzo[a]naphthacenequinone compound found to be active on a screen designed to investigate compounds with antimicrobial activity, produced by the actinomycete designated strain FMUSA5-5T. The strain was isolated from a bio-fertilizer of Musa spp. collected from Suphanburi province, Thailand. The chemotaxonomic characteristics and 16S rRNA gene analysis revealed that strain FMUSA5-5T is a member of the genus Nonomuraea. Low genome-based taxonomic criteria, average nucleotide identity (ANI) (82.8–88.3%), average amino-acid identity (AAI) (79.4–87.3%), and digital DNA–DNA hybridization (dDDH) (29.5–38.5%) values and several phenotypic differences between strain FMUSA5-5T and its closest type strains of the genus Nonomuraea indicated that strain FMUSA5-5T represents a novel species of the genus Nonomuraea and the name Nonomuraea composti sp. nov. is proposed for the strain. The crude extract from the culture broth of strain FMUSA5-5T displayed promising antimicrobial activity against several pathogens and led to the isolation of a novel secondary metabolite, pradimicin U. Interestingly, this compound displayed a broad spectrum of biological activities such as antimalarial activity against Plasmodium falciparum K1 (IC50 value = 3.65 µg/mL), anti-Mycobacterium tuberculosis H37Ra (MIC value = 25.0 µg/mL), anti-Alternaria brassicicola BCC 42724 (MIC value = 25.0 µg/mL), anti-Bacillus cereus ATCC 11778 and anti-Staphylococcus aureus ATCC 29213 (MIC values = 6.25 and 1.56 µg/mL, respectively). Moreover, the compound possessed strong anti-human small cell lung cancer (NCI-H187) activity with IC50 value of 5.69 µg/mL, while cytotoxicity against human breast cancer (MCF-7) and Vero cells was very weak (IC50 values of 52.49 and 21.84 µg/mL, respectively).