bluuebunny/crossref_metadata_2025 huggingface dataset:
Determining stress state of source media with identified difference between groundwater level during loading and unloading induced by earth tide
Authors: Yu Huaizhong , Yu Chen , Zhao Binbin , Yue Chong , Chang Yulong
Published: April 2021

The groundwater might be adopted as a useful tool to explore pre-seismic stress change in the crust, because it circulates in the deep crust and should be altered by the processes associated with the preparation of earthquakes. This work makes a new attempt that applies the load/unload response ratio (LURR) technique to study stress state of source media by calculating the ratio between water level during the loading and unloading phases. The change of Coulomb failure stress induced by earth tide in the tectonically preferred slip direction on the fault surface of the main shock is adopted for differentiating the loading and unloading periods. Using this approach, we test the groundwater level in the wells near the epicenters of some large earthquakes occurred in the Sichuan-Yunnan region of southwest China. Results show that the LURR time series fluctuate narrowly around 1.0 for many years, and climb to the maximum peaks prior to the main shocks. The magnitude of the pre-seismic peaks decreases with the distance from the epicenters. We hypothesized that the underlying physics of these changes might be explained by the pre-seismic dilatancy. The corresponding volume variations could be observed in the geodetic time series in the same neighborhoods.
Left atrial diameter, CHA2DS2-VASc score and type of atrial fibrillation predict pulmonary vein isolation outcome
Authors: Jurcevic Ruzica , Angelkov Lazar , Ristic Velibor , Vukajlovic Dejan , Otasevic Petar , Tasic Nebojsa , Bojic Milovan
Published: April 2021

Purpose Pulmonary vein isolation (PVI) is the most effective treatment strategy for atrial fibrillation (AF). This study evaluated Pulmonary Vein Isolation Outcome Degree (PVIOD) as a new semi-quantitative measure for PVI success after a 7-year follow-up and determined predictors associated with PVIOD.Methods We enrolled 117 patients with symptomatic AF who underwent PVI and after a 7-year follow-up applied PVIOD with 4 possible outcomes. PVIOD 1 group included patients with successful single PVI. PVIOD 2 group included patients with efficacy after ≥ 2 re-PV isolation and/or additional substrate modification (ASM). PVIOD 3 group contained subjects with clinical success after PVI±ASM. Patients with procedural and clinical failure were in PVIOD 4 group.Results In multivariate ordinal logistic regression analysis PVIOD was independently associated with longstanding persistent AF with paroxysmal AF as referent category: odds ratio (OR) 4.1, 95% confidence interval (95% CI) 1.3-12.8 (P=0.014), left atrial (LA) diameter: OR 1.2, 95% CI 1.1-1.3 (P<0.001) and CHA2DS2-VASc score: OR 1.5, 95% CI 1.0-2.2 (P=0.039). LA size, CHA2DS2-VASc score and AF type predicted 7-year probability for procedural and procedural with clinical failure. LA diameter >41mm (AUC 0.741, 95% CI 0.6-0.8, P<0.001) and CHA2DS2-VASc score ≥2 (AUC 0.718, 95% CI 0.6-0.8, P<0.001) predicted long-term procedural and clinical failure. Conclusion PVIOD is a new classification for PVI success. LA diameter, CHA2DS2-VASc score and AF type are independently associated with PVIOD and predict procedural and procedural with clinical failure after the 7-year follow-up. LA diameter >41mm and CHA2DS2-VASc score ≥2 predict long-term PVI failure.
Sustainability of Groundwater Resources of Weathered and Fractured Schists in the Rural Areas of Galicia (Spain)
Authors: Samper Javier , Naves Acacia , Pisani Bruno , Dafonte Jorge , Montenegro Luis , García-Tomillo Aitor
Published: April 2021

Water supply deficits in droughts, groundwater pollution and climate change are the main challenges for the sustainability of groundwater resources from hard rock aquifers in the rural areas of Galicia (Spain). Here we address the sustainability of groundwater resources of weathered and fractured schists in the rural areas of Abegondo municipality. The conceptualization of the hydrogeology of the study area includes: 1) The regolith, 2) The fractured rock layer; and 3) The underlying fresh bedrock. Groundwater flows mostly through the regolith and the fractured rock. Rainfall infiltration is the source of aquifer recharge. Groundwater discharges in seepage areas, springs and along creeks and valleys. The water table is generally shallow and shows seasonal oscillations of up to 4 m. The equivalent transmissivity ranges from 15 to 35 m2/d. Electrical resistivity tomography identifies a shallow water table and attests that the contact of the fractured rock and the fresh bedrock is highly heterogeneous. Groundwater resources were quantified with a hydrological water balance model. The mean annual recharge is approximately equal to 185 mm. Groundwater recharge at the end of the 21st century could decrease from 6% to 10% due to climate change. The decline in groundwater table could aggravate the shortages during droughts. Groundwater quality data show bacteriological and nitrate contamination due to a poor management of the manure in the fields and occasional discharges of slurry from pig and mink farms. Groundwater management and protection actions are proposed to prevent groundwater pollution and achieve a sustainable groundwater supply in the study area.
Cross-linked chitosan-glyoxal/kaolin clay composite: Parametric optimization for color removal and COD reduction of remazol brilliant blue R dye
Authors: Jawad Ali H. , Abdulhameed Ahmed Saud , Kashi Elmira , Yaseen Zaher Mundher , ALOthman Zeid A. , Khan Mohammad Rizwan
Published: April 2021

Kaolin clay (KN) was employed as an inorganic filler to modify a cross-linked chitosan-glyoxal as Schiff’s-based chitosan composite derivative (CTS-GLY). The resulting (CTS-GLY/KN) was found to be a promising composite synthetic biopolymer that can be potentially utilized for color removal as well as COD reduction of an industrial anionic dye (remazol brilliant blue R, RBBR). The surface porosity, crystallinity, morphology, functionality, charge, and amine content of the CTS-GLY/KN were studied using BET, XRD, SEM, FTIR, pHpzc and pH-potentiometric titration analyses, respectively. Response surface methodology-Box-Behnken design (RSM-BBD) was used to optimize the impact of the main input factors on the color removal and COD reduction of RBBR. The adsorptive performance CTS-GLY/KN towards RBBR was well-defined by both Langmuir and Freundlich isotherm models with highest adsorption capacity of 447.1 mg/g at 30 ˚C. This finding reveals that CTS-GLY/KN can be utilized as a promising, feasible, and environmentally friendly composite-biosorbent for color removal and COD reduction of textile dyes from aqueous medium.
Application of Electromagnetic Sensing and Infiltration Measurements to Evaluate Salinity Reclamation and Turfgrass Management Options for Improved Leaching
Authors: Semiz Gülüzar Duygu , Suarez Donald L. , Lesch Scott
Published: April 2021

Scarce freshwater resources in arid and semiarid regions means that recreational landscapes should use recycled or low quality waters for irrigation, increasing the risk of salinity and infiltration problems. We map salinity distribution within turf fields using electromagnetic sensing, evaluate need for leaching and evaluate post leaching results for subsequent management decisions. Electromagnetic measurements were made with two EM38 instruments positioned vertically and horizontally in order to determine salinity distribution. Sensor readings were coupled to GPS data to create spatial salinity maps. Next, optimal calibration point coordinates were determined via ESAP software. Soil samples were taken from 0-60 cm at 5 depths for each calibration point. Laboratory soil saturation percentage, moisture content, ECe and pHe of saturation extracts were determined for calibration to convert resistivity measurements to ECe. Next, ECe maps were created using ESAP software. Leaching for reclamation was performed by means of sprinkling. Treated municipal wastewater was utilized both for irrigation and for reclamation leaching. Low water content and high spatial variability of soil texture adversely affected the accuracy of the readings. Pre and post leaching surveys indicate that there was only a 30% decrease in salinity, very low relative to expected results considering the amount of water applied. This relatively low reduction in salinity and the lack of runoff during irrigation combined with infiltration measurements suggests that aeration techniques for healthier grasses led to water bypassing small pores thus limiting leaching efficiency. In this instance practices to improve infiltration lead paradoxically to less salinity reclamation than expected.
Last Millennium Drought-inducing Teleconnections of the West Pacific Gradient during ENSO
Authors: Zinke Jens , Browning Stuart A. , Hoell Andrew , Goodwin Ian D.
Published: April 2021

Conflicting evidence points to either a strengthening or weakening Walker Circulation over the 20th century based on changes in sea surface temperature and sea level pressure gradients between the western and eastern Pacific. Since small changes in Pacific temperature gradients connected with the El Niño Southern Oscillation (ENSO) are related to global climate anomalies, it is of paramount importance to develop robust indices of their past behaviour. Here, we reconstruct the difference in sea surface temperature between the west and central Pacific during ENSO based on the Last Millennium Paleo Hydrodynamics Data Assimilation since 1000 AD. We demonstrate that the strength of the West Pacific Gradient (WPG) is related to stronger atmospheric circulation and remote precipitation anomalies during both historical El Niño and La Niña events and societally relevant drought teleconnections. A strong negative WPG coupled with a strong zonal Pacific temperature gradient is associated with enhanced megadroughts between 1400 AD and the late 16th century. The 20th century stands out as the period with most extreme swings between positive and negative WPG conditions. We conclude that the WPG serves as a powerful index of Pacific Walker Circulation variability and their associated global climate teleconnections.
Insight into the Characteristics of Research Published in Complementary, Alternative, and Integrative Medicine Journals: A Bibliometric Analysis
Authors: Ng Jeremy Y.
Published: April 2021

Background: Complementary, alternative and integrative medicine (CAIM) can be described as diverse medical and healthcare interventions, practices, products, or disciplines that are not considered as part of conventional medicine. Inherent in its definition, CAIMs are comprised of a wide variety of therapies with highly variable safety and effectiveness evidence profiles. Despite this, the use of many CAIMs is highly prevalent among patients globally. The present study consists of a bibliometric analysis of CAIM journals. Methods: A single search of all International Standard Serial Number (ISSNs) of all journals categorized as “complementary and alternative medicine” (code 2707) based on the All Science Journal Classification (ASJC) was run on Scopus on April 17, 2021. All publication types were included; no further search limits were applied. The following bibliometric data were collected: number of publications (in total and per year), authors and journals; open access status; journals publishing the highest volume of literature and their impact factors; language, countries, institutional affiliations, and funding sponsors of publications; most productive authors; and highest-cited publications. Trends associated with this subset of publications were identified and presented. Bibliometric networks were constructed and visualized using the software tool VOSviewer.Results: A total of 172466 publications (42331 open access), were published by 219680 authors in 143 journals from 1938 to 2021. Since the 1940s, an upward trend with respect to the volume of publications can be observed, with a steep increase observed between the mid-2000s and mid-2010s. The journal that published the largest number of publications was the Journal of Natural Products (n=15144). The most productive countries included China (n=45860), the United States (n=29523), and Germany (n=10120); a number of the most common intuitional affiliations and funding sponsors also originated from these three countries.Conclusions: The number of publications collectively published in CAIM journals follows an upward trend. Given a high prevalence of CAIM use among patients, increased acceptance of CAIM among conventional healthcare providers, and growing interest in the research of CAIM, future work should continue to investigate and track changes in the publication characteristics of the emerging research on this topic.
Antifungal Activity of Linear and Disulfide-Cyclized Ultrashort Cationic Lipopeptides Alone and in Combination with Fluconazole Against Vulvovaginal Candida spp.
Authors: Czechowicz Paulina , Neubauer Damian , Nowicka Joanna , Kamysz Wojciech , Gościniak Grażyna
Published: April 2021

Vulvovaginal candidiasis (VVC) occurs in over 75% of women at least once during their lifetime and is an infection that significantly affects their health. Candida strains resistant to standard azole antifungal therapy and relapses of VVC are more and more common. Hypothetically, biofilm is one of the main reasons of relapses and failure of the therapy. Ultrashort cationic lipopeptides (USCLs) exhibit high antimicrobial activities. Our previous study on USCLs revealed that disulfide cyclization can result in selective antifungal compounds. Therefore, four USCL were selected and their antifungal activity were studied on 62 clinical strains isolated from VVC. The results showed that cyclic analogs have increased selectivity between fungal cells and keratinocytes and improved anticandidal activity than their linear analogs against both planktonic and biofilm cultures. On the other hand, linear lipopeptides in combination with fluconazole showed the synergistic effect. It was found that the minimum inhibitory concentrations of the tested compounds in combination with fluconazole were at least four times lower than when used separately. Our results indicate that combination therapy of VVC with USCLs and fluconazole at low non-toxic concentrations can be beneficial owing to the synergistic effect. However, further in vivo studies are needed to confirm this hypothesis.
Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro
Authors: Paull Jeremy , Heery Graham , Bobardt Michael , Castellarnau Alex , Luscombe Carolyn , Fairley Jacinth , Gallay Philippe
Published: April 2021

An effective response to the ongoing coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will involve a range of complementary preventive modalities. The current studies were conducted to evaluate the in vitro SARS-CoV-2 antiviral and virucidal activity of astodrimer sodium, a dendrimer with broad spectrum antimicrobial activity, including against enveloped viruses in in vitro and in vivo models, that is marketed for antiviral and antibacterial applications. We report that astodrimer sodium inhibits replication of SARS-CoV-2 in Vero E6 and Calu-3 cells, with 50% effective concentrations (EC50) for i) reducing virus-induced cytopathic effect of 0.002 to 0.012 mg/mL in Vero E6 cells, and ii) infectious virus release by plaque assay of 0.019 to 0.032 mg/mL in Vero E6 cells and 0.031 to 0.037 mg/mL in Calu-3 cells. The selectivity index (SI) in these assays was as high as 2197. Astodrimer sodium was also virucidal, reducing SARS-CoV-2 infectivity by >99.9% (>3 log10) within 1 minute of exposure, and up to >99.999% (>5 log10) shown at astodrimer sodium concentrations of 10 to 30 mg/mL in Vero E6 and Calu-3 cell lines. Astodrimer sodium also inhibited infection in a primary human airway epithelial cell line. The data were similar for all investigations and were consistent with the potent antiviral and virucidal activity of astodrimer sodium being due to inhibition of virus-host cell interactions, as previously demonstrated for other viruses. Further studies will confirm if astodrimer sodium binds to SARS-CoV-2 spike protein and physically blocks initial attachment of the virus to the host cell. Given the in vitro effectiveness and significantly high SI, astodrimer sodium warrants further investigation for potential as a nasally administered or inhaled antiviral agent for SARS-CoV-2 prevention and treatment applications.
DNA damage in cumulus cells generated after the vitrification of in vitro matured porcine oocytes and its impact on fertilization and embryo development
Authors: López Alma , Betancourt Miguel , Ducolomb Yvonne , Rodríguez Juan José , Casas Eduardo , Bonilla Edmundo , Bahena Iván , Retana-Márquez Socorro , Juárez-Rojas Lizbeth , Casillas Fahiel
Published: April 2021

Oocyte vitrification has become an important tool for the improvement of assisted reproduction in humans and other mammalian species. The toxicity and use of high cryoprotectants concentrations have been a limiting factor for cryopreservation success. The evaluation of the DNA damage generated in cumulus cells after mature cumulus-oocyte complexes vitrification can be considered as an indicator of oocyte quality since these cells play important roles in oocyte developmental competence. Alterations produced in these cells could compromise oocyte maturation, fertilization, and embryo development. Therefore, the aim of this study was to determine if matured cumulus-oocyte complexes exposure to cryoprotectants or vitrification affects both oocytes and cumulus cells viability, but also if DNA damage is generated in cumulus cells, affecting fertilization and embryo development. The DNA damage in cumulus cells was measured using the alkaline comet assay and expressed as Comet Tail Length and Olive Tail Moment. Results demonstrate that oocyte exposure to cryoprotectants or vitrification reduced oocyte and cumulus cells viability compared to control. Also, significantly higher DNA damage was generated in the cumulus cells after exposure to cryoprotectants and vitrification compared to control. In addition, fertilization and embryo development rates also decreased after exposure to cryoprotectants and vitrification. It was also found that fertilization and embryo development rates in granulose-intact oocytes were significantly higher compared to denuded oocytes in the control groups. However, a decline in oocyte fertilization and embryo development to the blastocyst stage was observed after cryoprotectants exposure or vitrification. This could be attributed to the reduction in both cell types viability, and the generation of DNA damage in the cumulus cells. These findings will allow to understand some of the mechanisms of oocyte damage after vitrification, and the search for new vitrification strategies to increase fertilization and embryo development rates.
High-Performance Multifunctional Photodetector and THz Modulator Based on Graphene/TiO2/p-Si Heterojunction
Authors: Jin Lichuan , Wei Miaoqing , Zhang Dainan , Zhang Lei , Zhang Huaiwu
Published: April 2021

In this paper, we have prepared a multifunctional device based on graphene/TiO2/p-Si heterojunction and systematically studied the optical response of the device in the ultraviolet-visible-infrared band and the transmission changes of terahertz waves in the 0.3-1.0 THz band under different bias voltages. As a photodetector, the “back-to-back” p-n-p energy band structure makes the device have a serious unbalanced distribution of photogenerated carriers in the vertical direction when light is incident from the graphene side, which ensures a higher optical gain of the device, so as to achieve a responsivity up to 3.6 A/W and a detectability of 4×1013 Jones under 750 nm laser irradiation. As a terahertz modulator, the addition of the TiO2 layer allows the device to continuously widen the carrier depletion region under negative bias, thereby realizing modulation of the terahertz wave, making the modulation depth up to 23% under − 15 V bias. However, there is almost no change in the transmission of the terahertz wave when positive bias is applied. An analogue of an electronic semiconductor diode effect is realized that allows passage of the terahertz wave only for negative bias and blocks the terahertz wave while positively biased.
Casting of recycled aluminum, Al + Cu + Mg alloy formation and lamination process of an electric current conductor
Authors: Holzschuh Gilson Gilmar , Moraes Jorge André Ribas , Garcia Sergio Boscato , Zanesco Izete , Kipper Liane Mallman , Schneider Rosana de Cassia
Published: April 2021

This research presents a methodology for the recycling process via casting, in which aluminum cans and primary (commercial) aluminum are transformed into a laminated tape, with the possibility of industrial application. This research was classified as bibliographic, exploratory, and experimental, since it used qualitative techniques to evaluate alternative materials. Its objective was to incorporate materials of different properties that could favor the making of a tape to be laminated. In the first casting, a recycled aluminum ingot was formed only with aluminum from beverage cans and had a material yield of 51%. In a second casting, commercial aluminum was added to the recycled aluminum ingot. After the casting process with the two cast materials, the ingot had a yield of 90%. A third casting was conducted together with the aluminum that was already formed by the ingot (50% recycled and 50% commercial). The purpose of this ingot was to incorporate other materials that could provide some characteristics, such as malleability and conductivity. The third casting was made from the second ingot, and incorporated copper and magnesium. For the design of the laminated tape, a cast was made to receive the molten aluminum from the third casting. The aluminum was cast into this mold and three tapes were produced, one with a thickness of 2 mm, another with a thickness of 3 mm and the last with a thickness of 4 mm. With these tapes, the objective was to laminate them in order to reduce their thickness to values ​​close to 0.5 mm. The casting process of aluminum cans with the addition of commercial aluminum, plus the incorporation of copper and magnesium, demonstrated facilities for thickness reduction in the process of making laminated tapes.
On the order of the non-primes of type 6n+5 and 6n+1
Authors: Wolmersdorfer Christoph
Published: April 2021

The fundamental importance of prime numbers for mathematics is that all other natural numbers can be represented as a unique product of prime numbers[1]. For centuries, mathematicians have been trying to find an order in the occurrence of prime numbers. Since Riemann´s paper on the number of primes under a given size, the distribution of the primes is assumed to be random[2]. Here, I show that prime numbers are not randomly distributed. Their positions are determined by the order of occurrence of the nonprimes of types 6n+5 and 6n+1. By using parametric sine functions, I will show here that all assumptions known today regarding the distribution of prime numbers larger than 3 are wrong. In particular, this refutes Riemann´s hypothesis of random distribution of prime numbers. Furthermore, I will show an exact primality test based on these parametric sine functions, which only needs the calculation modes +, -, · , : and only uses one parameter. There is no such deterministic primality test existing until today[3] [4].
Factors Affecting Cervical Cancer Screening Practice Among Women Attending Gynecology Out - Patient Department at Mettu Karl Referral Hospital, South West, Ethiopia, 2019
Authors: Nigatu Desalegn , Nigatu Dessalegn nigatu
Published: April 2021

Introduction : Globally, Cervical cancer is the greatest threat to women's health, which is the fifth cause of death accounting for all types of cancer deaths among women. Globally, 528000 new cases each year and the second most common in developing countries around 445,000 new cases develop cervical cancer each year. Cervical screening practice is the recommended for effective methods for prevention and early detection of cervical cancer. To increase the awareness of cervical cancer screening practice health education is pivotal in any prevention program aimed in reducing the overall prevalence of cervical cancer in the community. Objective : To assess cervical cancer screening practice and associated factors among women attending gynecology out -patient department and maternal and child health at mettu karl referral Hospital, South west, Ethiopia, 2018.Methods : Institutional based cross-sectional study was carried among 321 patients. Systematic random sampling was applied to select study subject and descriptive analysis were employed to describe the percentages and number distributions of the respondents for socio-demographic characteristics. The data was collected through interviewing of respondents and the data was entered EPI data version 4.2 and analyzed by using SPSSS version 20.Bivariate analysis was also used to see the association of independent with the dependent variable. Crude and adjusted odds ratios with the corresponding 95% confidence intervals were computed. A P-value less or equal to 0.05 was considered statistically significant in this study. Result: In this study a total of 321 clients were participated in the study. The mean age was 35.79 with SD±11.46. The majority of participants 225(70.1%) were not intended cervical cancer screening while 96 (29.9%) were intended cervical screening respectively. Age ≥50 (AOR=26.603;95%CI=8.167,86.662),age between 40-49 (AOR=4.152,95%CI=1.630,10.576), had smoking (AOR=0.179;95CI=0.087,0.369), women’s who had STD AOR=0.169; 95%CI=0.82, 0.347), multiple sexual partner of the husband(AOR=1.221; 95%CI=0.687, 2.200) and were used contraceptive (AOR=0.172; 95%CI=0.070, 0.422)were found to have strong association with cervical screening behaviors. CONCLUSION AND RECOMMENDATIONS: According to this finding, the overall rate of those participants who had good screening for cervical cancer practice were about 29.9%. Maternal age, using smoking, using contraceptives, presence of sexually transited disease, and having multiple sexual partner of the husband are predominantly stated factors associated with cervical screening practice.
Finding unknown stimulants applied in food supplements using Artificial Intelligence
Authors: Gavai Anand , Bouzembrak Yamine , Bulk Leonieke , Liu Ningjing , Overbeeke Lennert van , Heuvel Lucas , Mol Hans , Marvin Hans
Published: April 2021

The world market for food supplements is large and is driven by the claims of these products to, for example, treat obesity, increase focus and alertness, decrease appetite, decrease the need for sleep or reduce impulsivity. The use of illegal compounds in food supplements is a continuous threat, certainly because these compounds and products have not been tested for safety by competent authorities. It is therefore of the utmost importance for the competent authorities to know when new products are being marketed and to warn users against potential health risks. In this study we present an approach to detect new and unknown stimulants in food supplements using machine learning. More than 20 new stimulants were identified from two different data sources, namely scientific literature applying word embedding on > 2 million abstracts and articles from formal and social media on the world wide web using text mining. The results show that the developed approach may be suitable to detect “unknowns” in the emerging risk identification activities performed by the competent authorities, which is currently a major hurdle.
Signalling networks constructed by integrative analysis of multi-omics in peripheral blood mononuclear cells in systemic lupus erythematous patients
Authors: Song Wencong , Zheng Fengping , Huang Shaoying , Cai Wanxia , Yu Haiyan , Hong Xiaoping , He Jingquan , Dai Weier , Yin Lianghong , Tang Donge , Liu Dongzhou , Dai Yong
Published: April 2021

Background: Systemic Lupus Erythematous (SLE) is a complex chronic autoimmune disease with productive autoantibodies and multiple organ systems damage. Currently, effective diagnosis and treatment for SLE are still challenged and the mechanism investigation of SLE will be helpful for developing the efficiency of disease diagnosis and treatment. Yet, the mechanism of SLE has not been clearly revealed. Thereafter, it needs more studies on the mechanism of SLE. We aim at investigating and verification critical signaling pathways underneath the molecular mechanism of SLE disease and constructing a systematic signaling network by integrating data from different omics. Methods: 20 pairs of experimental groups (the SLE patients and healthy people) were recruited in our study. Omics technologies and biomolecules included genomics (DNA), whole transcriptomics (miRNAs, lncRNAs, circRNAs and mRNAs), proteomics (proteins) were used for collecting high throughput data from peripheral blood mononuclear cells (PBMCs) of subjects in our study. Joint analysis method of Multi-omics was taken advantage of in our studies for investigating some disease-related regulatory signaling networks.Results: Potential biomolecules that contain unique expression patterns and disease related signaling pathways in SLE were identified in our study. These pathways and biomolecules include complement and coagulation cascades (C1q, C6), Systemic lupus erythematosus (HIST1H2BA, C1QC), Oxidation (NFYB, WFS1, ATXN3L), apoptotic (PIK3R3, GADD45G, CTSF), JAK-STAT (TYK2, STAT1/2), TNF signaling, Cell proliferation, cellular senescence et al. Signaling pathways identified by different omics were connected with each other by sharing some common molecules and constructed the potential systematic regulation networks in SLE.Conclusions: Multi-omics technologies and the integrative analysis method develop some novel potential biomarkers and systemic signaling networks, which promotes our understanding of SLE disease and extend information for improving studies of diagnosis and treatment.
ECOLOGICAL AND ECONOMIC INDICATORS OF SUSTAINABLE DEVELOPMENT OF REGIONS IN THE CONTEXT OF ENSURING THE QUALITY OF POPULATION LIFE
Authors:   Voronezh State University of Forestry and Technologies named after G.F. Morozov, Zinovieva I. , Azarova N. ,   Voronezh State University of Forestry and Technologies named after G.F. Morozov, Nebesnaya A. ,   Voronezh State University of Forestry and Technologies named after G.F. Morozov
Published: April 2021

Ecological and economic indicators are a kind of indicator of the economic state of the regions, the ongoing processes, trends in the regional economy, the quality of life of population and characterize the sustainable development of the regions. These indicators should take into account the regional power structures that make management decisions for regional development. Often, these indicators are formed in isolation from each other, and the analysis of statistical reports does not allow the data to be formed up-to-date. The study identifies the reasons associated with the problems of sustainable development of the region’s economy, and notes the connection of these problems with the quality of life of the population. It is noted that ensuring a high level of economic development in the regions is often at the expense of the state and quality of the environment. It is noted that Russia is following the path of international trends in the development of the regional economy – compliance with the Sustainable Development Goals (SDGs). This is due to the support of the global strategy of economic development within the framework of the “green economy”. The article examines the components of the environmental quality indicators of the Russian regions, and also establishes a correlation between them and the criteria for evaluating the effectiveness of the work of the heads of regions and regional executive authorities, which ultimately reflects the level of development of the region as a whole. In the work, using the National Environmental Rating for 2020 of the subjects of the Russian Federation, leaders and outsiders among the regions of the Russian Federation are identified by the level of their environmental condition. According to the results of the ecological and economic assessment, the authors ranked the complex indicator of the state of environmental indicators in the regions, which include a list of six indicators: the level of emissions of harmful substances, the discharge of polluted wastewater, production and consumption waste, water consumption, energy consumption, and environmental protection costs. The researchers analyzed the positions of the Voronezh Region in terms of the quality of life in the region and finding a position in the environmental rating of the subjects of the Russian Federation. The authors propose a grouping of regions by the value of a complex indicator, study the indicators of the ecological state of the regions, and correlate between sustainable development and the quality of life of the population of the regions
The impact of digital technologies on the economy development of the regions in the Russian Federation
Authors:   Perm Institute (branch) of the Russian Economic University named after G. V. Plekhanov, Oborin M.
Published: April 2021

The article analyzes the indicators of digital technologies and the digital economy, as well as their unevenness in the context of the subject of the Russian Federation. The object of the research is digital technologies; the subject of the research is the directions of the digital technologies’ influence on the development of the country regions’ economy. The purpose of the study is to determine the features and directions of the digital technologies’ influence on the economy development of the regions in the Russian Federation. The objectives of the study are determined by the situational assessment of statistical data on digitalization of various areas of the socio-economic structure of the regions, as well as in the context of subjects: population, business. Research methods are the following: analysis of statistics of expenditures on the digital technologies’ introduction, the level and pace of digitalization of society, modeling of socio-economic processes. The dynamics of the development of expenditures on digital technologies and indicators of the use of electronic document management in organizations, the level of access to the Internet among the population are analyzed. High growth rates and indicators of digitalization development in individual areas of the service sector related to the functioning of e-government are identified. Uneven rates of introduction of digital technologies in the economy of the regions are determined. The study allowed us to identify the main socio-economic areas that are dynamically developing under the influence of digitalization: finance, services, and public administration. The main directions of the digitalization impact on the economy of the regions are identified, which include financial and economic indicators of industries, clusters, and large businesses; coefficients of modernization and investment in innovative projects, including those designed for internal development. High rates of implementation of digital solutions and technologies contribute to improving the regional management quality, increasing the standard of living and improving the financial and economic results of enterprises of various types of activity
Development and distribution of karst and suffusion processes on the territory of the Belgorod region, assessment of their impact on the environment
Authors:   Belgorod State National Research University, Sarychev D. , Sarychev А. ,   elgorod Law Institute of the Ministry of Internal Affairs of the Russian Federation named after I. D. Putilin, Arkhiptsev I. ,   elgorod Law Institute of the Ministry of Internal Affairs of the Russian Federation named after I. D. Putilin, Demchenko N. ,   elgorod Law Institute of the Ministry of Internal Affairs of the Russian Federation named after I. D. Putilin, Rybalchenko А. ,   elgorod Law Institute of the Ministry of Internal Affairs of the Russian Federation named after I. D. Putilin
Published: April 2021

Relevance. The problem of studying karst-suffusion processes is that soluble rocks in Russia occupy large areas. The Belgorod region is rich in Cretaceous deposits, which are widespread throughout the territory. Due to the fact that carbonate rocks are susceptible to dissolution by surface and groundwater leads to the formation of karst forms. Such forms open and form places of karst waters’ accumulation, open fissure and cave systems and are becoming areas with an increased environmental hazard to the life of people, infrastructure, civil and industrial buildings. Dangerous exogenous geomorphological processes negatively affect the economic development of the region. The purpose of the article is to study the factors influencing the development and distribution of karst and suffusion processes, the reasons for their occurrence, as well as the impact on the environment. Among hazardous exogenous geological processes, karst-suffusion processes are the most unpredictable. Their occurrence has negative consequences for the economics and economic activities of the region. The main methods used in this study are observation method, laboratory experiment and mathematical modeling. The method of mathematical modeling has relatively recently come into the use by the researchers and allows for a better reproduction of processes on physical models. This study is aimed at determining the interaction of karst and suffusion processes, as well as assessing their impact on the environment. The zoning of the karst and suffusion distribution on the territory of the Belgorod region has made it possible to identify the causes of these processes. To prevent the development and spread of karst-suffusion processes, an integrated approach to the analysis of manifestation, drawing up a forecast plan and measures to counter negative consequences is required. Based on the results of the study, measures were proposed to minimize damage to agricultural land, residential and farm buildings, as well as measures to combat karst and suffusion processes. It should be noted that the results of the study and the developed measures to prevent the negative consequences of karst and suffusion processes can be used in human agricultural activities, construction of civil and industrial enterprises, their reconstruction, laying of communications and development of carbonate new deposits
Political subjectivity of the Transbaikal Territory in the framework of municipal changes
Authors:   Transbaikal State University, Beydina T. , Kazaryan I. ,   Transbaikal State University, Kukharsky A. ,   Transbaikal State University, Novikova A. ,   Transbaikal State University
Published: April 2021

The article is devoted to the identification and analysis of the reform of municipal territories in the Transbaikal Territory, which actualizes the problem of political subjectivity. The article is of a controversial nature, since the tendencies of territorial development issues in the modern period have controversial points related to the unification of municipalities. The urgency of the problem is due to the formation of municipal districts and the need to generalize their practical experience of functioning. The problem is actualized by the fact that the base of the Priargunsky municipal district. In 2020 the Priargunsky municipal district was created, which requires the development of a unified municipal system and taking into account the municipal changes in Transbaikalia, primarily within the framework of the “Electronic Municipality” program. The purpose of the article: analyzing the political subjectivity of the Transbaikal Territory, to characterize the changes in local self-government bodies, taking into account the information openness of municipalities. Practice confirms that the low efficiency of the enlargement of municipal territories and the creation of municipal districts in the underdeveloped, depressed constituent entity of the Russian Federation, the Transbaikal Territory, is obvious. The article describes the relationship between administrative and public administration with the implementation of federal target programs and with the implementation of state and municipal decisions. Political subjectivity is inextricably linked with administrative and public administration, which is focused on a centralized system of leadership and is identical with the concept of “executive power”, and also has many similarities with state policy. Administrative and public administration is an imperative and administrative activity, which is implemented in normative (soft) and hard (prohibitions, orders) forms. The system of administrative and public administration includes the entire structure of government bodies and is focused on executive bodies of both federal and regional levels and on local government institutions. The novelty of the study is due to the fact that the complexity of the municipal territories of Transbaikalia is revealed; the incompleteness of the municipal reform is characterized from the point of view of managerial development and the need to take into account the strategic approach to territorial administration. The scientific significance of the article is emphasized by the identified interrelationships of administrative-state management and local self-government in the reform of municipal territories in the constituent entities of the Russian Federation, one of which is the Transbaikal Territory
Numerical Simulation of the Perforated Shell’s Oscillations in a Vibrational Priller
Authors: Demianenko M. , Volf M. , Skydanenko M. , Yakovchuk V. , Pavlenko I. , Liaposhchenko O.
Published: April 2021

The widespread catalysts and nuclear fuel production are the sol-gel technology, including several stages, namely, the raw materials preparation, dispersing it into drops, the granules formation in gas and then in liquid media, granules removal with liquid separation. The vibration granulator is proposed to use on the dispersion stage. One of the problems in their development is determining the vibrational characteristics of a perforated bucket filled with liquid to a certain level. Considering that vibrations are transmitted from the emitter disk through the liquid melt and cause vibrations of the perforated shell, in research, it was decided to use the Fluent Flow and the Transient Structural modules of the ANSYS Workbench software. As a result, numerical simulation results of the emitter disk vibration effect on the cylindrical body are presented. Also, parameters of a discrete mathematical model are evaluated by the bucket vibrations characteristics. The corresponding model considers the inertial, stiffness, and damping properties of functional elements. Additionally, according to the modal analysis results of the priller body, it was determined the eigenfrequencies of the hydromechanical system. Finally, based on the numerical simulation results and their analysis using Fourier transformations, it was determined that the oscillations of the lower part of the bucket, consisting of two harmonic oscillations that equal 230 Hz and 520 Hz.
Innovations in human resource management: impact of demographic characteristics, quality of interpersonal relationships on counterproductive work behaviours
Authors: Szostek Dawid
Published: April 2021

This paper describes the selected demographic characteristics as moderators of the impact of the quality of interpersonal relationships at work on counterproductive work behaviours. The main purposes of the research are describing: 1) how interpersonal relationships at work influences the intensity of counterproductive work behaviours; 2) how sex, age, education, length of service and type of job moderate the influence of interpersonal relationships at work on counterproductive work behaviours; 3) how the above-mentioned demographic characteristics influence interpersonal relationships at work and counterproductive work behaviours separately. The studies on the literature indicated that there were no comprehensive research results concerning those problems. The research paper fills a gap in the literature relating to the impact of interpersonal relationships at work on counterproductive work behaviours and the relation to modelling this impact by demographic characteristics of employees (sex, age, education, length of service, type of job). To achieve the study purposes, the author conducted a survey conducted on a sample of 1336 active employees in Poland. The survey period was 2018-2019. The IBM SPSS Statistics and IBM SPSS Amos were used to analyze data. Based on Structural Equation Modelling, it was that:1) interpersonal relationships at work negatively impacted on the intensity of counterproductive work behaviours against another individual; 2) the strength of influence of interpersonal relationships at work on counterproductive work behaviours did not change relevantly in modelling with selected demographic characteristics (sex, age, education, length of service, type of job); 3) only education, current kind of job and service length had a relevant influence on interpersonal relationships at work and counterproductive work behaviours. The research results could be useful for managers. In their activities, managers should systematically monitor interpersonal relationships at work and counterproductive work behaviours taking into account employees' demographic characteristics. In this process, managers should pay particular attention to education, type of current job, and service length.
Companies performance management: the role of operational flexibility
Authors: Yousuf Allam , Zeynvand Lorestani Vahid , Felföldi Janos , Zatonatska Tetiana , Kozlovskyi Serhii , Dluhopolskyi Oleksandr
Published: April 2021

The article summarizes the arguments on minimizing the uncertainty level caused by numerous unforeseen circumstances due to using operational flexibility to increase companies' efficiency (example of small and medium enterprises in the pharmaceutical sector of Iran). The research aims at investigating the relationship between operational flexibility and a company's performance to examine the impact of environmental uncertainty on these relationships. This study was conducted as quantitative. The deductive method using the synergy of systematization of scientific background on the problem and the empirical proof of the formulated hypotheses became a methodological study tool. The article provides evidence of the economic-mathematical model based on data from small and medium-sized pharmaceutical Iranian companies. The study hypotheses are as follows: 1) operational flexibility has a positive effect on the productivity of the pharmaceutical sector of Iran, represented by small and medium-sized companies; 2) uncertainty determines the relationship between the operational flexibility and efficiency of small and medium-sized pharmaceutical companies in Iran. The model constructed by the authors allowed measuring the relationship between variables using regression analysis and moderation analysis (Hayes model). The total number of companies included in the sample is 113. In turn, 228 managers of these pharmaceutical companies took part in the surveys (Iran example). The empirical analysis results showed that the mix flexibility indicator has practically no effect on companies' efficiency, and the volume flexibility and product development flexibility indicators generally have a positive effect on the performance of companies in the pharmaceutical sector. On the other hand, the environmental uncertainty indicator does not help reduce the relationship between the operational flexibility indicator and companies' performance in the pharmaceutical sector of Iran's economy. The study results could be useful for planning small and medium enterprises' activities in the context of improving their performance.