bluuebunny/crossref_metadata_2025 huggingface dataset:
PKDG: Prior Knowledge based Domain Generalization Model for fundus image segmentation
Authors: Xia Jianan , Zeng Lili , Li Tengfei , Xue Jingyan , Zhao Chuanchuan , Zhou Xuezhong
Published: July 2024

Convolutional neural network performance is prone to be significantly affected by the domain difference between the training data (source domain) and the test data (target domain).To address this issue and simultaneously to meet the multi-institutional healthcare data privacy protection needs, we propose a Prior Knowledge based Domain Generalization (PKDG) model for segmenting the optic cup and disc regions. Unlike existing methods, we incorporate clinical a priori knowledge into two phases. In the model training phase, a Priori Knowledge Module (PKM) is introduced to fuse client-side high-level information with server-side shared feature to generate a new dataset that simulates the differences between different domains. Further, A priori knowledge constraints are imposed on the model training process to enhance its generalization capability. In the model generalization phase, the Visualization Module (VM) reconstructs the shape of the segmentation results based on the intermediate representations, thus improving the visual interpretability. The proposed PKDG model provides a framework for optic cup and disc segmentation that enables privacy-preserving multicenter collaborative disease supporting diagnosis while ensuring robustness and superior performance in terms of accuracy and visual interpretability.
Facial and Palm-Based Biometric Authentication and Data Security
Authors: Tiwari Chandra Sekhar , Jha Vijay Kumar
Published: July 2024

Biometric Authentication (BA) is frequently used for authentication owing to its high recognition rate. The existing biometric hiding algorithms execute data embedding on areas that do not encompass key features of the biometric. Moreover, these techniques lacked authorization. Thus, a Secure Data Transfer model with BA and Blockchain (BC)-based authorization is proposed. Primarily, the data owner registers their details and the registered face and palm image undergoes pre-processing. By employing Pruned Residual Network 50 (PRESNET 50), the facial landmarks are extracted from the pre-processed face image. Next, Digit Folding based Log Facial Jaw Points Curve Cryptographic (DF-LFJPCC) is executed based on the jaw points to generate a secret key. Then, the Tan Sigmoid-based Convolutional Neural Network (TS-CNN) classifier is trained with the features of the pre-processed images and facial landmarks. After registration, the user logins, and their processed face and palm features are given to the trained TS-CNN for authenticating the user. The secret is also used to improve the authentication process. After successful login, the file to be uploaded is converted into cipher, which is then encrypted using Log Facial Jaw Points Curve Cryptographic (LFJPCC) and uploaded to the cloud server. In the end, authorization is performed in the BC based on the hashcode generated using Faro shuffle -Tiger (FS-Tiger) when a user requests data. As per the experimental analysis, the proposed technique outperforms prevailing models.
Formation of the Electronic Educational Environment in the Conditions of Vocational Education Digitalization
Authors: Shevkun Anna V. ,   Transbaikal State University, Pirozhnikova Anastasia M. P ,   Transbaikal State University
Published: July 2024

Modern education is undergoing significant changes, which are associated with the requirements in the conditions of a society digitalization. Digitalization of education is carried out on the basis of the priority project “Modern digital educational environment in the Russian Federation”. This study is devoted to the problem of education digitalization through the introduction of an electronic and digital educational environment at the university, as well as the problem of the willingness of teachers to participate in this process. Based on the analysis of the research, the article reveals the features of the introduction of digital technologies in professional education both in academic and extracurricular activities. The didactic features of the digital tools use in the process of formation and assessment of the level of certain competencies formation in the training of future specialists are investigated. The conditions of formation and development of information, communication and technological competence among students and teachers are revealed. In order to effectively form information and communication competence, a digital educational space is being created in educational institutions, including an information and communication infrastructure that promotes the introduction of an electronic educational environment and makes it possible to ensure the availability of high-quality education to consumers, including the organization of distance learning. To master the elements of an electronic information educational environment formation, the article considers the results of the introduction of the course “Electronic Educational Environment”, which was implemented among teachers of the Transbaikal State University. After studying this course, the teachers mastered the main features of the Transbaikal State University website, services and tools for evaluating oral surveys and written works of students, examined the features of working with an interactive whiteboard, as well as services for various visualization techniques. All these elements of the electronic educational environment will allow organizing a high-quality educational process in all areas of training at the university
Ecological and Pedagogical Education of Teachers
Authors: Pustovalova Vega V. ,   Information and Methodological Centre
Published: July 2024

The task of updating the content of environmental education is acute all over the world due to the globalization of the global resource crisis and the acute need to revise the value and worldview foundations of human relations with nature. Ecological education is considered as the platform of education for sustainable development, aimed at qualitative transformation of the interaction culture between society and nature. Directions for updating the content of environmental clearly identified in the Jubilee Report of the Club of Rome (2017), Roadmaps of the Global Action Program on Education for Sustainable Development (2014, 2021), the Concept of environmental education in the system of national general education (2022). The documents emphasize interdisciplinary, natural-scientific-social-humanitarian-technological, nature of modern environmental education for sustainable development, its integrating function, which means orientation of all education to ideas, values and meanings of behavior for sustainable development. Such global task demands serious reorganization of teachers’ training content and professional development, and in a limited time. Our research has shown that less than 2 % of general education teachers know and understand the goals of environmental education for sustainable development. The authors consider staff preparedness for implementation of the Environmental Education Concept to be critical. The article is devoted to description of the role, directions and ways of ecological education of general education teachers through their networking. Generalization of the seven years accumulated experience of such work has allowed to make the following conclusions. Serious barriers in updating the value and worldview foundations of contemporary environmental education are: subject reductionism, which dominates in teacher training, and insufficient attention to forming a picture of the world in its unity and general cultural competence; technological unsolved problem of interaction between subject teachers in solving “cross-curricular” subject problems; continued construction of environmental education content “from the bottom up”, from the level of educational materials, rather than from the pre-subjects level; and the lack of a clear and unified approach to environmental education. Ecological education of teachers remains at the level of the 1980s, orienting them towards nature conservation and gradually forming their anthropocentric view of the interaction between man and nature. It is concluded that there are worldview gaps in the issues of environmental education of teachers. The means of ecological and pedagogical education for overcoming such gaps within the network partnership of teachers are determined. Examples of increasing accessibility of complex categories of modern environmental education for teachers-practitioners in order to form ecocentric ideas of professional activity are given.
On the Concept of Russian Environmental Education in the International Context
Authors: Dzyatkovskaya Elena N. ,   Institute for Educational Development Strategy of the Russian Academy of Education
Published: July 2024

The paramount importance of mankind in solving environmental problems, the acuteness of which continues to increase, gives rise to a planetary discourse around the concepts of education for sustainable development. The discussion focuses on the issues of their goals, priorities, organization principles, correlationwith environmental education. The article confirms the conclusion of foreign researchers that today there is not a single serious discussion about the transition to sustainable development, which would not include, on the one hand, the change of goals and methods of education and, on the other hand, would not be connected with the mission of environmental education to form a culture of sustainable development. On the example of comparison of conceptual approaches to environmental education in Western (USA) and Eastern (India) countries the author makes a conclusion about their originality as well as similar understanding of problems of environmental education for sustainable development, its goals, principles of realization, place in education for sustainable development. In the light of solution of raised problems, typical for different countries, main provisions of domestic Conception of environmental education in the system of general education (2022) are considered. Both its adherence to general world tendencies and novelty of solutions suggested by it are proved. Ways of making environmental education for sustainable development “transversal” and interdisciplinary character in the general education system are considered: development of metalanguage, common for all school subjects; introduction of basic model of personal environmental culture as a result of environmental education; realization of general subject ecologization technology; use of scientifically grounded system of criteria and indicators of environmental education, as well as combination of its forward-looking and regenerative orientation. The article notes that the key provisions of the concept have been tested for over 10 years in the course of experimental studies in 18 regions of the country in interdisciplinary research, combining pedagogical, culturological, activity, axiological and semiotic approaches.
Effect of chemical absorption on Jeffery Fluid Flow in saturated Porous Media with variable thermal conductivity
Authors: Disu Akeem Babatunde , Omokhuale Emmanuel , Salawu Sulyman Olakunle
Published: July 2024

This study investigates the impact of species absorption of Jeffery fluid flow through a saturated permeable medium with variable thermal conductivity. The dimensional partial nonlinear derivative model controlling the chemical reacting fluid flow is transformed to invariant form.  The resulting flow equations are computed numerically using an approximated finite implicit Crack-Nicolson. A chemical absorption of fluid reactant occurs in a boundless vertical device.   Computations are performed for different parameters to examine their sensitivity under isothermal temperature conditions. The computed results are offered graphically for qualitative and quantitative insights into the flow behaviour. The obtained outcomes revealed that the fluid flow rate rises with an increasing values of the parameters and, and it damps with upsurge in the values of the parameters,  and. The heat transfer field is reduced with enhancing values of the thermal source, viscous dissipation and time, but declines for a boosted value of the terms suction and Prandtl number. Also, the mass transfer field is higher when mass absorption and time are increased, and diminish with an elevate in the values of Schmidt number and chemical reactions.
Characteristics candlenut shell-based activated Carbon for reduction Iron (Fe) in surface water from Bratasena Tulang Bawang, Lampung
Authors: Elisa Elisa , Shintawati Shintawati , Afifah Dian Ayu , Ramandani Adityas Agung
Published: July 2024

Candlenut shells are only used as fuel, and some are thrown away, so their use has not been maximized. Because of their high carbon content, candlenut shells may be used to create adsorbents. This study looks at how different activator concentrations of KOH activators can be used to make adsorbents from candlenut shells. The study will investigate how various activator concentrations affect the ability of adsorbents based on candlenut shells to bind molecules. Furthermore, the investigation will examine the possible uses of these adsorbents in diverse sectors, including air purification and wastewater treatment. This research was carried out using the Completely Randomized Design (CRD) method, which consisted of 1 activator KOH concentration of 0.5 M, 1 M, 1.5 M, 2 M, and 2.5 M with 3 replications each. The finding demonstrated that adsorbent products activated with 0.5 M KOH yield the highest quality and satisfied SNI 06-3770-1995 requirements for an ash and water content of 10.21% and 0.98%, respectively. The adsorbent product has an iodine absorption capacity of approximately 639.39 mg/g, comparable to SNI 06-3770-1995. For iron metal, the adsorbent product exhibits an adsorption capacity and absorption efficiency of 0.14 mg/g and 98.30%, respectively. The Freundlich adsorption isotherm model is suitable for this investigation, with a Kf value of 0.14 mg/g and an R2 of 0.9999.
Antioxidant activity assay of Roselle (Hibiscus sabdariffa) seeds Ethanol extract with DPPH radical scavenging using UV-Vis Spectrophotometer
Authors: Syahara Muhammad Alwi , Helilusiatiningsih Nunuk , Irawati Titik
Published: July 2024

Hibiscus sabdariffa (Roselle) is known to have a strong antioxidant compound. Thus, the calyx becomes the most important area to research. Another part of this plant that was starting to be known for its benefits is rosella seeds. Roselle seeds are a source of fat-soluble antioxidants. The aim of this study was to investigate the antioxidant activity of Roselle Seed Ethanol Extract (RSEE) with the DPPH (1,1-Diphenyl-2 Picrylhidrazyl) radical scavenging method. This research begins by doing the extraction of Roselle seeds using ethanol (96%) as a solvent and then assessing the antioxidant activity (Radical Scavenging Activity/RSA) of the extract, which is compared with the ascorbic acid standard at several concentrations (5-200 ppm). Antioxidant activity was assessed with DPPH Radical Scavenging using UV-Vis spectrophotometer and IC50 value parameters. The results of this study were the absorbance of DPPH from spectrophotometer at 517 nm was 0,824 (purple color). The absorbance of RSEE and ascorbic acid at 5 ppm to 200 ppm, respectively 0.523-0.124 and 0.594-0.112. The antioxidant activity (RSA) of the RSEE and ascorbic acid, respectively was  57.93% and 59.24%. The IC50 value of RSEE was 30.158 μg/ml and as comparison is ascorbic acid, the IC50 value was 26.948 μg/ml. Thus, the antioxidant activity of roselle seeds ethanol extract (RSEE) belongs to a very strong category (50 μg /ml). This is due to the presence of several phenolic compounds and unsaturated fatty acid derivatives.
An unsupervised machine learning algorithm approach using K-Means Clustering for optimizing Surface Wave Filtering in seismic reflection data
Authors: Hartono Hartono , Anwar Haerul , Umam Rofiqul , Takahashi Hirotaka
Published: July 2024

Surface waves often cause significant noise in seismic data, complicating the interpretation of subsurface structures. Traditional filtering methods, such as FK filtering, usually struggle with non-stationary noise and require extensive manual parameter tuning. This study explores the effectiveness of using K-means clustering, incorporating attributes such as amplitude, frequency, and phase to filter surface waves from seismic data. Synthetic seismic data were first generated to test the proposed method, ensuring its robustness before application to real field data. Attributes were extracted from each seismic trace, including instantaneous amplitude, frequency, and phase. These attributes were used as input parameters for the K-means clustering algorithm. The identified clusters corresponding to surface waves were then used to filter these waves from the seismic data. The K-Means clustering effectively differentiated surface waves from reflected waves in both synthetic and real seismic datasets. The method demonstrated that by including phase as an attribute, alongside amplitude and frequency, the accuracy of surface wave detection and filtering significantly improved. The synthetic data showed a clear separation of wave types, validating the method. When applied to real field data, the approach consistently removed surface waves, clarity of seismic reflections crucial for subsurface analysis.
Assessing the availability and necessity of menstruation-friendly toilets in public and private sector sites in Kathmandu, Nepal
Authors: Mathew Esther Elsa , Reed Elisabeth , Karki Jasmine , Chhantel Rubina , Jolly Pauline , Lhaki Pema , Shrestha Sadeep
Published: July 2024

Much of the world's public toilet infrastructure does not consider the needs of menstruators. Nepali menstruators, 18–52 years old, were surveyed at 40 different sites in three major cities in Nepal. During a random site visit, 20 eligible participants at each site were selected by convenience sampling to complete a quantitative survey assessing the importance of the eight aspects of a menstruation-friendly toilet, as outlined by the government of Nepal. Only one of 40 of the toilets assessed met all eight indicators of a menstruation-friendly toilet. None of the survey participants felt comfortable using a public toilet when menstruating, and 88.8% reported facing challenges using public toilets when menstruating.
Vivir con los otros: experiencias basadas en la regulación emocional en un colegio de Bogotá
Authors: Peñaranda Betancur María Daniela , Bermeo Moreno Alexandra , Ramírez Cabanzo Ana Brizet
Published: July 2024

Este trabajo presenta la experiencia pedagógica que surge de un proyecto investigativo en una Institución Educativa Distrital situada en la ciudad de Bogotá, que busca identificar cuál es el impacto que tienen las estrategias de regulación emocional en las relaciones con los otros, evidenciadas en los niños y niñas de tercer grado. Metodológicamente se realizó bajo el corte cualitativo, desde la Investigación Acción Participación, basada en la sistematización de experiencias como proceso que analiza, reflexiona y aporta al reconocimiento y la transformación de las prácticas sociales desde una mirada crítica. De esta manera se identificaron las distintas respuestas de los niños y niñas respecto a emociones como la alegría, el miedo y el enojo; la construcción de estrategias que les permitan conciliar la calma durante los momentos en que se desestabilicen emocionalmente y la reflexión y el análisis frente a las afectaciones que se pueden generar en el sujeto mismo o en los otros, para el fortalecimiento de las competencias socioemocionales y la mejora de la convivencia escolar. Se destaca la importancia de educar desde la sensibilidad docente para una formación integral del ser humano, en donde la afectividad tenga el mismo grado de relevancia que las áreas básicas.
Motivación intrínseca y su relación con el aprendizaje del factor común
Authors: Muñoz Tello Andrés Felipe , Dossman Calderón Diana Marcela
Published: July 2024

Teniendo en cuenta que existe una necesidad constante en el estudiante de sentirse competente para llevar a cabo intereses propios y desafíos, es importante determinar los factores y los elementos que desencadenan la aparición de la motivación intrínseca, particularmente en el aprendizaje significativo de las matemáticas. En este artículo de investigación se determinaron las relaciones que demuestran la presencia de la motivación intrínseca y el aprendizaje significativo del factor común en estudiantes de octavo grado de una institución educativa de Santiago de Cali, Colombia. Con este propósito, en este documento se muestra un estudio de caso, de tipo descriptivo-explicativo, con enfoque mixto, el cual se llevó a cabo con fuentes primarias obtenidas a partir de entrevistas a docentes y estudiantes, y de la aplicación de una prueba de conocimiento sobre el uso del factor común. Los resultados mostraron que, en la enseñanza del factor común, los docentes condicionan a los estudiantes a estudiar a cambio de una nota, una recompensa externa. Esto inhibe el intercambio continuo y constante entre la motivación intrínseca y el desarrollo de habilidades en el uso del factor común, pues al realizar ejercicios de nivel más alto se necesita de más concentración y confianza.
Desafios e oportunidades na hotelaria de Dourados, Mato Grosso do Sul
Authors: Statella Martins Patrícia Cristina , Lamberti Eliana , Ebehardt Júnior Werno , Robert de Souza Rodriguez Wesley , Brunelle Almeida Freitas Lara
Published: July 2024

A realidade da hotelaria em Dourados, Mato Grosso do Sul, é tema central deste estudo que objetivou conhecer o perfil da mão de obra empregada por meio da percepção dos seus empresários e gestores locais. Especificamente, buscou-se identificar competências e oportunidades para turismólogos, bem como compreender o processo de recrutamento, cargos e carreiras. O diagnóstico preliminar é de que há descompasso entre a demanda do mercado de trabalho e a oferta do ensino superior. Ou seja, o capital intelectual formado pela academia e a empregabilidade encontrada por egressos dos cursos de turismo. Para tanto, fez-se investigação bibliográfica de caráter exploratório sobre a temática e pesquisa de campo com aplicação de questionários semiestruturados, direcionados aos empresários e gestores hoteleiros por meio de amostra não probabilística. Os resultados indicaram que desafios e impactos dos períodos cíclicos da economia afetam o turismo, sensível às mudanças conjunturais. Se em termos nacionais, o mercado de trabalho é impactado por processos de precarização, baixa remuneração e rotatividade, é compreensível que em Dourados estas características estejam presentes. Conclui-se que a hotelaria douradense é composta por hotéis que, em sua grande maioria, é gerida pela ordem familiar, limitando a empregabilidade de capital humano qualificado e a instrumentalização do empreendimento, sobretudo quanto à capacidade competitiva e inovadora.
Município de Interesse Turístico
Authors: Cunha Souza Mariana Cristina , Neves Guimaro Ana Carolina
Published: July 2024

No estado de São Paulo, o turismo é considerado vetor de desenvolvimento, tanto que políticas públicas específicas são propostas para fomentar a atividade. Um exemplo é a Lei Complementar Nº 1.261, de 29 de abril de 2015, que estabelece requisitos para a classificação de Estâncias e Municípios de Interesse Turístico (MITs). Nesse cenário, o governo do município de Presidente Prudente iniciou o processo de candidatura em 2015 e em 2018 enviou a proposta revisada, desde então obteve duas negativas. Na última solicitação, os critérios de potencial turístico e serviço de informação turística não foram atendidos. O objetivo geral deste artigo é analisar a trajetória do governo municipal de Presidente Prudente no processo de solicitação do MIT. A pesquisa,  classificada como aplicada, explicativa e de abordagem qualitativa, baseou-se em revisões bibliográficas e documentais, a partir de consultas nas plataformas científicas do SciELO, Periódicos CAPES e Google Acadêmico. Igualmente, dados e informações foram solicitados ao Governo do Município de Presidente Prudente, nos departamentos que participaram e/ou estão atuando na condução do título de MIT. Realizaram-se entrevistas com roteiro semiestruturado, junto aos profissionais que atuam diretamente no processo de solicitação do título. Todo material foi organizado por temas e analisado por meio da técnica da Análise de Conteúdo. Os resultados demonstram que há necessidade de conformidade com critérios técnicos e legais, uma vez que a aprovação do título tem sido influenciada pela não sistematização de informações e apresentação documental conforme a legislação exige. Com as negativas, o processo encontra-se em revisão, com possibilidades de parecer favorável em nova solicitação da titulação pelo governo municipal.
Therapeutic Potential of Nanocarriers in the Management of Rheumatoid Arthritis
Authors: Mittal Vishnu , Sharma Anjali , Sharma Devkant
Published: July 2024

RA is characterized by chronic inflammation, joint damage, and systemic complications.
Despite available treatments, many patients experience inadequate responses or adverse effects.
Novel therapeutic strategies are needed to address these challenges. Nanoparticulate technologies
offer promising opportunities to enhance drug delivery and targeting in RA treatment.
The main objective is to explore recent advancements in nanoparticulate technologies for RA treatment,
focusing on their potential to improve drug delivery and efficacy while minimizing adverse
effects. This review examines recent studies on nanoparticulate technologies for treating rheumatoid
arthritis (RA), focusing on the use of nanocarriers for targeted drug delivery. Studies investigating
the effectiveness of nanocarriers in delivering drugs specifically for RA treatment were included
in the analysis. Nanoparticulate technologies have shown promise in improving the delivery
and efficacy of RA treatments. Various nanocarriers, such as liposomes, polymeric nanoparticles,
and micelles, have been developed to enhance drug delivery to inflamed joints. These nanocarriers
loaded with curcumin, Aceclofenac, Boswellic acid, methotrexate, resveratrol, etc. can improve
drug stability, prolong circulation time, and enhance targetability to inflamed tissues. By
overcoming the limitations of traditional therapies, these technologies have the potential to improve
patient outcomes and quality of life. Future research should focus on optimizing nanocarrier
design, evaluating long-term safety, and conducting clinical trials to validate their efficacy in RA
management.
The Influence of Phytoconstituents for the Management of Antipsoriatic Activity in Various Animal Models
Authors: Yadav Ravina , Yadav Tejpal , Upadhayay Ashutosh , Alam Md. Sabir , Dubey Gaurav , Kumar Vikram , Sahu Adarsh
Published: July 2024

:

It is possible for psoriasis to manifest at any point in a person's life, regardless of their age, gender, or geographic location. It is a chronic immune-linked inflammatory skin ill-ness that affects individuals of various racial and ethnic origins. It is recognized to be a long-lasting condition. Because of the significant contribution that natural products have made, there has been a significant advancement in the treatment of skin illnesses such as psoriasis. The biggest number of phytochemicals derived from a wide range of plants and herbs are now being used in a variety of applications throughout the whole world. Additionally, a number of phyto-chemicals, including aloe-emodin, psoralen, curcumin, and others, have been effectively ex-tracted in pure or clear form, and they have shown a great deal of efficacy in the treatment of psoriasis illness. There is evidence that few herbal remedies are effective, and the occurrence of these phytochemicals provides more proof. When synthetic medications are used for chronic therapy, they may cause a variety of adverse consequences; hence, the exploration of natural pharmaceuticals can give a successful natural treatment with a minimal amount of adverse ef-fects. Within the scope of this concise review, a number of plant sources that possess anti-pso-riatic activity are investigated, and the antipsoriatic effects of these plant sources are shown on a number of animal models using particular pathways.
Deciphering the Causality between Gut Microbiota Dysbiosis and Poisoning by Narcotics and Psychodysleptics: A Mendelian Randomization Analysis
Authors: Wang Ning , Su Zhenbo
Published: July 2024

Background:

This study investigates the connection between gut microbiota and poisoning
caused by narcotics and psychodysleptics, using Mendelian randomization (MR) to explore possible
causal relationships.

Methods:

The study employed the MR analysis, leveraging genetic variants as instrumental variables
to facilitate robust causal inference. Data for gut microbiota was extracted from the MiBioGen study,
integrating genome-wide genotyping data with 16S fecal microbiota profiles. Outcome metrics were
based on the Finngen study. Genetic instruments were meticulously extracted based on stringent criteria,
and harmonized with SNP outcomes associated with "Poisoning by narcotics and psychodysleptics
[hallucinogens]". The inverse-variance weighted (IVW) method was utilized for MR analysis, supplemented
by sensitivity analyses including MR-Egger Regression, Weighted Median Approach, and
Leave-One-Out Cross-Validation.

Results:

Among various microbial groups, nine showed significant statistical links. Specifically, Class
Negativicutes (OR 5.68, 95% CI 2.13-15.16, p = 0.0005) and Order Selenomonadales (OR 5.68, 95%
CI 2.13-15.16, p = 0.0005) were notably associated. These findings were consistent across different
sensitivity analyses.

Conclusion:

The relationship between gut microbiota and the adverse effects of narcotics and psychodysleptics
is an emerging area of research. Our MR study identifies certain microbes that might influence
the body's response to these substances. These insights could help in predicting and treating the
effects of narcotics and psychodysleptics in the future.
Can Apigenin Be an Effective Therapeutic Agent Against Experimental Renal Ischemia-Reperfusion Injury?
Authors: Topdağı Ömer , Güler Mustafa Can , Eraslan Ersen , Ekinci Akdemir Fazile Nur , Tanyeli Ayhan , Özbek Şebin Saime , Şebin Engin
Published: July 2024

Aim: This study aims to reveal the effects of two doses of apigenin (API) against renal ischemia-reperfusion injury (R I/R).
Material and Methods: For this purpose, 5 and 10 mg/kg doses of API were preferred in our study, and the groups were designed as sham, R I/R, 5 mg/kg API, and 10 mg/kg API groups for the implementation of the experimental protocol. In the R I/R model, 1-hour ischemia and 24-hour reperfusion periods were preferred. Oxidative and inflammatory markers were measured biochemically in samples taken at the end of the experiment.
Results: Biochemical results showed that oxidative and inflammatory markers increased significantly in the R I/R group, but antioxidant activities decreased significantly. In the 5 and 10 mg/kg API groups, R I/R damage was alleviated considerably, with these markers approaching the sham group values.
Conclusion: As a result, the study's results determined that two different doses of API were effective against R I/R-induced kidney damage.
PERAN NANOHIDROKSIAPATIT PADA PENYEMBUHAN TULANG ALVEOLAR DALAM KEDOKTERAN GIGI: STUDI TINJAUAN LITERATUR
Authors: Hanafi Putri Agustine , Ji Na Chung , Dwi Nawang Sasi Anggiona , Cahaya Ningtyas Devi , Putri Kay Allif Natasya , Zulfarhan Zaky Pahlevi Achmad
Published: July 2024

Latar Belakang: Nanohidroksiapatit merupakan salah satu bentuk aplikasi nanoteknologi yang memiliki potensi dalam kedokteran gigi salah satunya sebagai bahan cangkok karena kemiripan komposisi kimianya dengan komponen bahan tulang dan gigi manusia. Nanohidroksiapatit dapat menstimulasi penyembuhan tulang dan mendorong aktivitas osteoblastik. Tujuan: Mengetahui peran nanohidroksiapatit terhadap penyembuhan tulang alveolar. Metode: Literature review dengan melakukan pencarian artikel berdasarkan kata kunci melalui beberapa database, selanjutnya artikel diseleksi menggunakan metode PRISMA. Hasil: Berdasarkan 50 artikel yang dianalisis, diketahui bahwa nanohidroksiapatit berperan terhadap penyembuhan tulang alveolar. Kesimpulan: Nanohidroksiapatit memiliki manfaat yang sangat menjanjikan dalam kedokteran gigi, khususnya dalam regenerasi tulang alveolar. Nanohidroksiapatit merupakan bahan yang relatif baru dan penerapannya dalam kedokteran gigi harus diteliti lebih lanjut.
Current Insight on Percutaneous Coronary Intervention in Non-ST Elevation Acute Coronary Syndrome
Authors: Oktaviono Yudi Her
Published: July 2024

Percutaneous coronary intervention (PCI) is a cornerstone in the management of non-ST elevation acute coronary syndrome (NSTE-ACS), offering significant improvements in patient outcomes. Risk stratification is critical in guiding the urgency and timing of PCI, with invasive strategies recommended for high-risk patients identified by clinical, electrocardiographic, biomarker assessments, or validated scores. Multivessel coronary artery disease is frequently observed in patients with NSTE-ACS and is correlated with an increased likelihood of recurrent myocardial infarction and mortality. Preferably during the index procedure, complete revascularization should be considered in patients with stable hemodynamics. Functional invasive evaluation, including fractional flow reserve, may help assess the hemodynamic significance of coronary lesions and decide whether a non-culprit stenosed vessel prompts revascularization. Intravascular imaging techniques with optical coherence tomography and intravascular ultrasound are essential for evaluating lesion characteristics, optimizing stent deployment, and enhancing the precision of PCI. Overall, a personalized interventional approach in NSTE-ACS incorporating risk stratification, timely intervention, careful consideration of multivessel disease, and advanced diagnostic modalities is paramount in enhancing patient prognosis and minimizing recurrent ischemic events. Keyword: Percutaneous Coronary Intervention, Non-ST Elevation Acute Coronary Syndrome Multivessel Disease; Intravascular Imaging; Coronary Physiology; Complete Revascularization.
Early Detection of Subclinical Rheumatic Heart Disease Through Echocardiographic Screening: A Study in North Sumatra, Indonesia
Authors: Ardini Tengku Winda , Ilyas Kamal Kharazzi , Nasution Ali Nafiah , Ketaren Andre Pasha , Napitupulu Bertha Gabriella , Batubara Gio Justicia , Sarastri Yuke , Raynaldo Abdul Halim , Siregar Abdullah Afif , Siregar Yasmine Fitrina , Dewita Auliya , Andra Cut Aryfa , Lubis Anggia Chairuddin
Published: July 2024

Background: Given the urgent need to address the significant morbidity and mortality associated with Rheumatic Heart Disease (RHD) in Indonesia, there is a growing interest in exploring cost-effective screening approaches, such as handheld echocardiography. Objective: The purpose of this study was to ascertain the prevalence of RHD in North Sumatra, Indonesia. Material and Methods: This descriptive observational study was conducted within the population of North Sumatra from 2022 to 2023. Junior high school students aged 12 to 15 years were included from randomly selected schools in Langkat, Tebing Tinggi, and Labuhan Batu. Data collection encompassed various parameters, including social demographic information, parental characteristics, environmental factors, household details, anthropometric measurements, physical assessments, auscultation findings, and echocardiographic data. The data were analyzed descriptively. Result: In our study, a total of 692 children were examined, with an average age of 12.9 years and a standard deviation of 1.1 years, among whom 42.5% were male. Utilizing echocardiographic evaluations, we identified RHD in four children, yielding a prevalence rate of 0.6%. Further examination of these cases revealed that the majority, accounting for three individuals (75%), exhibited borderline RHD, while one child (25%) presented with definite RHD. Conclusion: In our study population, the prevalence of RHD was 0.6%. A broader echocardiographic screening program is necessary to determine the overall prevalence of RHD, assess the disease burden, and identify individuals earlier to prevent adverse outcomes. Keyword: Echocardiography, Prevalence, Rheumatic Heart Disease, Screening.
The Consequences of a Heart Condition: Acute Stroke and Limb Ischemia Secondary to Massive Intracardiac Thrombus in a Young Female with Dilated Cardiomyopathy
Authors: Lestari Defyna Dwi , Tjahjono Cholid Tri , Kurnianingsih Novi
Published: July 2024

Background: Dilated cardiomyopathy (DCM) is associated with the increased occurrence of left ventricular (LV) thrombosis caused by cardiac dysfunction. This condition is associated with significant mortality and morbidity because of its significance as a potential source of systemic emboli. We are reporting a case of Acute Stroke and Limb Ischemia in a Young Female Patient with DCM. Case Illustration: A 20-year-old female was referred to our hospital due to pain in her right lower extremities and weakness in her right limb. She had been diagnosed with peripartum cardiomyopathy five years earlier. A general physical examination found her right lower limbs to be cold and pulseless. A neurological examination revealed hemiparesis involving the right side of her body. The chest radiograph showed cardiomegaly. Electrocardiography indicated sinus rhythm with LVH. The transthoracic echocardiograms revealed significant LV systolic failure with a massive thrombus at LV. The Duplex ultrasound showed a thrombus at the right dorsal pedis artery, and a head CT scan revealed an acute infarct. The patient was started on heparin and bridged with warfarin 5mg orally daily, and she was uneventfully discharged after one week. Conclusion: DCM had been associated with thrombosis, stroke, and an increased risk of thromboembolism. Previous studies had documented decreased thromboembolic events due to administering anticoagulants. Keyword: Acute Stroke, Dilated Cardiomyopathy, Limb Ischemia, Massive Intracardiac Thrombus.
Successful Management in Unprovoked Upper Extremity Deep Vein Thrombosis: Case Report
Authors: Noverike Nikhen , Kurnianingsih Novi , Rizal Ardian , Rahimah Anna Fuji
Published: July 2024

Background: One to four percent of all cases of deep vein thrombosis (DVT) occur in the upper extremities. Effective thrombolysis for upper extremity deep vein thrombosis (UEDVT) can be achieved with a combination of vascular interventions such as angioplasty, which is continued with catheter-directed thrombolysis (CDT) and anticoagulant therapy. Case Illustration: We presented the case of a 40-year-old man who developed sudden pain and swelling in his right upper extremity. The thrombus was located in the right subclavian vein, confirmed by duplex ultrasonography. Laboratory results were normal. The patient was diagnosed with unprovoked UEDVT. He underwent venography, which showed an acute-on-chronic lesion at the right subclavian vein. We decided to use double access, tried to inflate the balloon to fragment the thrombus, several times of thrombo-suction, and then continued with Catheter-directed thrombolysis (CDT) using Alteplase. The patient continued oral anticoagulant therapy with Rivaroxaban. After 6 months of follow-up, there wasn’t any complaint. Evaluation of Duplex ultrasonography showed normal results without any recurrent thrombus Conclusion: This case revealed how to treat acute-on-chronic lesions of unprovoked UEDVT with a comprehensive management method not only with balloon fragmentation and CDT but also anticoagulant therapy and showed a good outcome and no signs of bleeding complication. Keyword: Anticoagulant and Thrombolysis, Catheter-directed Thrombolysis, Unprovoked UEDVT, Upper Extermity Deep Vein Thrombosis.
Tailoring Management of May-Thurner Syndrome : Case Comparison
Authors: Suprapta Aloysius Yuwono , Kurnianingsih Novi , Damanik Gracelia Ruth Elizabeth
Published: July 2024

Background: May-Thurner syndrome (MTS) is a post-thrombosis syndrome (PTS) of the lower extremity. This disorder results from compression and/or irritation from adjacent crossing the right common iliac artery to the left iliac venous. In this report, we present two management comparisons of patients with left lower DVT with consideration of MTS. Case Illustration: The first patient is a 49-year-old male soldier presented with chronic unilateral left leg edema and a mild clinical presentation for 9 months. Previous Doppler ultrasonography (DUS) revealed a thrombus in the left venous femoralis. Anticoagulant was given for six months. DUS and CT venography following anticoagulant treatment revealed a thrombus in the left venous femoralis. Venography revealed entire blockage of the left common femoral and left iliac veins, with adequate collateral flow. PTV was attempted twice and failed both times. The patient was following a conservative therapy (walking exercise and stocking compression) that yielded positive outcomes. The second patient is a 53-year-old male soldier has had unilateral left leg edema for three years, which has increased during the previous three months with ulceration and active bleeding. Previous Doppler ultrasonography revealed a thrombus in the left iliac externa. Anticoagulants and compression stockings were given for eight months, but the symptoms persisted. CT and venography revealed a complete blockage from the left popliteal vein to the iliac vein. Femoral crossover bypass surgery yielded favorable results. Conclusion: Clinically moderate MTS demonstrated fair results with conservative treatment, whereas clinically severe MTS showed superior results with bypass surgery. Keyword: Anticoagulant, May-Thurner Syndrome, Palma Procedure.
The Complexity of Premature Coronary Artery Disease
Authors: Noverike Nikhen , Rahimah Anna Fuji , Rohman Mohammad Saifur
Published: July 2024

Premature Coronary Artery Disease presents a significant health concern globally, characterized by the onset of coronary atherosclerosis at an early age, typically before the age of 55 in men and 65 in women. This review provides a comprehensive examination of the various aspects of premature CAD, ranging from its underlying pathophysiology to diagnostic modalities such as coronary angiography. Beginning with an overview of the risk factors contributing to premature CAD, including genetic predispositions, lifestyle factors, and metabolic disorders, the review delves into the intricate mechanisms involved in the initiation and progression of atherosclerosis. Furthermore, the review discusses the clinical manifestations and challenges associated with diagnosing premature CAD, particularly in asymptomatic individuals. It examines the utility of non-invasive imaging techniques, stress testing in identifying coronary artery stenosis, cardiovascular risk and the principles of coronary angiography. The review outlines the principles of coronary angiography, including patient preparation, procedural techniques, and interpretation of angiographic findings. In conclusion, this comprehensive review provides insights into the multifaceted nature of premature CAD, elucidating its pathogenesis, clinical presentation, and diagnostic evaluation, with a focus on the pivotal role of coronary angiography in guiding therapeutic interventions and optimizing patient outcomes. Keyword: Coronary Angiography, Premature Coronary Artery Disease, Risk Factor.
Neutrophil-Lymphocyte Ratio (NLR) as A Predictor for Non-ST Elevation Myocardial Infarction (NSTEMI) in the Emergency Room
Authors: Zunardi Lutfi Hafiz , Anjarwani Setyasih , Prasetya Indra
Published: July 2024

Background: The usefulness of the NLR as an approach to identifying cases of acute coronary syndrome (ACS) needs to be improved. Objective: This research was designed to determine the effectiveness of the NLR in identifying individuals who presented to the emergency room complaining of anginal due to ACS. Material and Methods: The single-center cross-sectional study was performed at Saiful Anwar General Hospital in Malang, East Java, Indonesia, from July 2020 to December 2023. Patients were involved in this study with complaints of angina suspected of ACS. During further observation in the emergency room, based on the findings of the troponin I analysis, individuals were divided into unstable angina pectoris (UAP) and NSTEMI. Result: Study results were collected from 282 individuals diagnosed with Non-ST Elevation Acute Coronary Syndrome (NSTEACS), with 75.9% male and a mean age of 58.39 ± 10.27 years. The NLR threshold was 4.5 (AUC: 0.78, 95% CI: 0.765–0.867, P <.001) assessed during admission, which showed a sensitivity of 79% and a specificity of 78% in accurately predicting the probability of subsequent troponin positivity. Multivariate analysis revealed that the NLR at hospitalization remained an essential marker of troponin positivity during follow-up. Conclusion: In the end, NLR could be considered an initial test in emergency services to predict the diagnosis of NSTEMI in people experiencing angina Keyword: Marker Inflammation, NLR, NSTEMI, Troponin I.
On the Use of Nano Formulation Techniques in Improving Drug Delivery Syatem
Authors: Ambika T.
Published: July 2024

Nanoparticles are a revolutionary medication delivery technology, as we all know. They have several positive impacts, such as the drug’s efficacy and safety. We enumerate its efficaciousness during drug distribution in this review. One of the methods for more precisely delivering pharmacological substances to the intended tissue while lowering the total dosage and possible harmful side effects is drug nanoformulation. They may function as carriers of various active medicinal ingredients into a particularly body regions, or they may be therapeutic agents in and of themselves. As a truly multidisciplinary field of study, nanotechnology has benefited greatly from the contributions of chemists, physicists, biologists, and pharmaceutical scientists in the development of novel therapeutic and diagnostic approaches. The application of nanotechnology has advanced non-invasive imaging, nutraceutical delivery, cancer and HIV/AIDS treatment, and more. This review makes it clear that the use of nontechnology in medicine and drug delivery has created new avenues for individualized and secure treatment options. In the end, researchers are able to administer medications for longer periods of time with less frequent doses (sustained release), higher precision, and penetration in difficult-to-access tissues through the alteration of molecular size and surface features.
Berichtgeving rond de beursgang van KPN
Authors: De Ridder Jan A.
Published: July 2024

In case of big companies, sensitive to publicity, the analysis of news is important to get a clear insight into the process of image building. The computer programme CETA is a tool for content analysis. CETA transposes texts into a set of connected assertions which forms a discourse network. After coding a text by using CETA a lot of interesting questions about the content of the news can be answered. In this article we report on a research we did for the Dutch post- and telecommunication company KPN. In that research we reconstructed the image of KPN based on the positive and negative news. We also paid attention to the relationship between interventions and news. In this article we want to show the benefits and the possibilities for image building research of analysing news with CETA.
Regionale televisie in Vlaanderen: toetsing van de praktijk aan de decretale bepalingen inzake programmatie, reclame en sponsoring
Authors: De Bens Els , Janssens Hilde , Van Landuyt Dieder
Published: July 2024

The aim of this contribution is to give an overall picture of the 10 regional TV-stations in Flanders, to analyze the current legal framework and to reveal the discrepancies between theory and practice and to point out legal bottlenecks and desirable adjustments to the decree on regional television in Flanders. The findings are not only based on literature, but also on the results of a comparative content analysis concerning the programming, advertising and sponsoring, covering the period 1994-1995.