bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge Gaps among Patients and Providers in HPV‐Related Oropharyngeal Cancer: A Systematic Review
Authors: Parsel Sean M. , Barton Blair M. , Beatty Sydney , Friedlander Paul L.
Published: March 2020

Objective

To describe the level of knowledge of human papillomavirus (HPV) and HPV‐associated oropharyngeal squamous cell carcinoma (OPSCC) among the general population and health care providers.

Data Sources

Systematic search was performed on December 20, 2018, using MEDLINE (1966 to December 2018), EMBASE (1975 to December 2018), Web of Science (1900 to December 2018), and CENTRAL (1996 to December 2018) databases. English‐language literature involving human subjects was used, and studies were limited to case series, case‐control, cohort, and randomized controlled trial designs.

Review Methods

Studies were included if they assessed knowledge of HPV and HPV‐associated OPSCC. The primary outcome measure was the knowledge of HPV‐associated OPSCC among the general population and with health care providers. Meta‐analysis of proportions was attempted using random‐effects model. The PRISMA guidelines were used for accuracy of reporting.

Results

Thirty‐two studies were included with 17,288 participants. There was a high degree of heterogeneity preventing completion of a meta‐analysis. Knowledge of HPV and HPV‐associated OPSCC varied between the general population and health care providers. The proportion of the general population and health care providers with knowledge of HPV ranged from 16% to 75% and 21% to 84%, respectively. Knowledge of HPV‐associated OPSCC was greater in health care providers and ranged from 22% to 100% compared with the general population, which ranged from 7% to 57%.

Conclusion

There is a knowledge gap of HPV‐associated OPSCC for both the general population and health care providers. Additional education may not only increase awareness but may also result in prevention and earlier detection.
Estimation of municipal waste generation of Turkey using socio-economic indicators by Bayesian optimization tuned Gaussian process regression
Authors: Ceylan Zeynep
Published: March 2020

Accurate estimation of municipal solid waste (MSW) generation has become a crucial task in decision-making processes for the MSW planning and management systems. In this study, the Gaussian process regression (GPR) model tuned by Bayesian optimization was used to forecast the MSW generation of Turkey. The Bayesian optimization method, which can efficiently optimize the hyperparameters of kernel functions in the machine learning algorithms, was applied to reduce the computation redundancy and enhance the estimation performance of the models. Four socio-economic indicators such as population, gross domestic product per capita, inflation rate, and the unemployment rate were used as input variables. The performance of the Bayesian GPR (BGPR) model was compared with the multiple linear regression (MLR) and Bayesian support vector regression (BSVR) models. Different performance measures such as mean absolute deviation (MAD), root mean square error (RMSE), and coefficient of determination (R2) values were used to evaluate the performance of the models. The exponential-GPR model tuned by Bayesian optimization showed superior performance with minimum MAD (0.0182), RMSE (0.0203), and high R2 (0.9914) values in the training phase and minimum MAD (0.0342), RMSE (0.0463), and high R2 (0.9841) values in the testing phase. The results of this study can help decision-makers to be aware of social-economic factors associated with waste management and ensure optimal usage of their resources in future planning.
Loneliness, cumulative inequality and social capital in later life: Two stories
Authors: Hagan Robert , Manktelow Roger , Taylor Brian
Published: March 2020

The potential impact of cumulative inequality upon loneliness in later life is under-researched. This study applies Ferraro and Shippee’s axioms of cumulative inequality to the narratives of two Northern Irish older women, who completed semi-structured diary entries over a 16-week period, recording and reflecting on their social lives and their personal histories. The two women were subsequently interviewed on the basis of what they had recorded. These stories reveal how the life trajectories of these two individuals are influenced by the different experiential impact of bonding and bridging social capital. Despite similar life experiences, significant and substantial differences emerged in the women’s stories, relating to work life, social class, the restrictions of a caring role, and physical and mental health. These two narratives not only provide evidence of the impact of cumulative inequality on loneliness but also highlight the lifetime impact of socio-economic status and access to capital affecting older women’s vulnerability to loneliness.
Does Exposure to the Choose Water Campaign Increase Parental Intentions to Promote More Water and Less Sugar-Sweetened Beverage Consumption?
Authors: Caldwell Julia I. , Robles Brenda , Tyree Rachel , Fraser Renee White , Dumke Kelly A. , Kuo Tony
Published: March 2020

Purpose:

To assess if exposure to the Choose Water public health media campaign increased parents’ intentions to promote healthier beverage consumption in their household.

Design:

A cross-sectional evaluation administered post-campaign.

Setting:

A 2017 internet panel survey in Los Angeles County, California.

Participants:

The survey included 499 parents of young children.

Intervention:

The Choose Water media campaign included digital media and out-of-home advertisements (eg, transit shelters, interiors of buses) in both English and Spanish.

Measures:

Dichotomous outcome variables were parental intentions to give child(ren) (1) more water and (2) less sugar-sweetened beverage consumption in their households. The independent variable was campaign exposure, categorized as no exposure, exposed but did not discuss visual, and exposed and discussed visual with someone.

Analysis:

Descriptive, bivariate, and multivariable logistic regressions.

Results:

Among those who were exposed and discussed a campaign visual, the adjusted odds of intending to promote water consumption were 2.82 times greater than for those who reported no exposure (95% confidence interval [CI]: 1.46-5.46). Similar odds to promote less sugar-sweetened beverage consumption were observed for those who were exposed and discussed a campaign visual (adjusted odds ratio: 3.27, 95% CI: 1.76-6.08). Those with the lowest educational attainment discussed the visual(s) less (10.5%).

Conclusion:

Word of mouth may enhance health messaging by allowing time for intended audiences to process campaign content within their interpersonal network.
Resonances and nonlinear vibrations of circular cylindrical shells, effects of thermal gradients
Authors: Iarriccio Giovanni , Zippo Antonio , Pellicano Francesco , Barbieri Marco
Published: March 2020

In this paper, the results of an experimental campaign focused on the vibrations of shells are presented. More specifically, the goal is to investigate the effect of thermal gradients across the shell thickness on the nonlinear dynamics. The shell is made of polymeric material and an aluminum mass is clamped on one end of the shell; the other shell end is clamped to an electrodynamic shaker, which provides a base harmonic excitation. Tests are performed in a controlled environment where a thermal gradient on the shell thickness is generated by means of a climatic chamber and an internal cartridge heater. Different temperature gradients and base excitation levels have been considered. The nonlinear dynamic scenario is analyzed through amplitude–frequency diagrams, bifurcation diagrams, waterfall diagrams, time histories, Fourier spectra, phase portraits, and Poincaré maps. Results show a strong effect of the temperature on the dynamic response of the shell: subharmonic, quasi-periodic, and chaotic vibrations take place as well as large amplitude vibrations, high sound levels are detected.
The Association Between an Antecedent of Transient Ischemic Attack Prior to Onset of Stroke and Functional Ambulatory Outcome
Authors: Poupore Nicolas , Strat Dan , Mackey Tristan , Nathaniel Thomas I.
Published: March 2020

Background:

Specific clinical risk factors linked to transient ischemic attack (TIA) could affect functional ambulatory outcome following thrombolytic therapy in patients having ischemic stroke with a prior TIA (TIA-ischemic stroke). This issue was investigated in this study.

Methods:

We retrospectively analyzed data from 6379 ischemic stroke patients of which 1387 presented with an antecedent TIA prior to onset of stroke. We used logistic regression model to identify demographic and clinical risk factors that are associated with functional ambulatory outcome in patients with TIA-ischemic stroke treated with thrombolytic therapy.

Results:

In a population of TIA-ischemic stroke who received recombinant tissue plasminogen activator, patients with a history of stroke (odds ratio [OR] = 3.229, 95% confidence interval [CI] = 1.494-6.98, P = .003) were associated with increasing odds of improvement in functional ambulation, while the female gender (OR = 0.462, 95% CI = 0.223-0.956, P = .037) was associated with reducing odds of improvement. In the non-TIA group, dyslipidemia (OR = 1.351, 95% CI = 1.026-1.781, P = .032) and blood glucose (OR = 1.003, 95% CI = 1.0-1.005, P = .041) were associated with the increasing odds of improvement while older patients (OR = 0.989, 95% CI = 0.98-0.999, P = .029) with heart failure (OR = 0.513, 95% CI = 0.326-0.808, P = .004) and higher lipid level (OR = 0.834, 95% CI = 0.728-0.955, P = .009) were associated with reducing odds of improvement in ambulation.

Conclusion:

In a population of TIA-ischemic stroke with thrombolytic therapy and a clearly defined TIA without focal ischemic injury, regardless of associated clinical risk factors, a TIA prior to a stroke is not associated with reducing odds of improved ambulatory outcome, except in female patients with TIA-ischemic stroke.
Primary progressive multiple sclerosis presenting under the age of 18 years: Fact or fiction?
Authors: Abdel-Mannan Omar , Cortese Rosa , Wassmer Evangeline , Hemingway Cheryl , Thompson Alan , Brownlee Wallace , Ciccarelli Olga , Hacohen Yael
Published: March 2020

Previous cohort studies on paediatric multiple sclerosis (MS) have reported very low frequencies for a primary progressive MS (PPMS) course ranging from 0% to 7%. We identified six patients presenting prior to the age of 18 years and fulfilling the 2017 McDonald Criteria for PPMS. Presentation with progressive neurological symptoms and signs in young people should prompt evaluation for genetic causes such as leukodystrophies, hereditary spastic paraparesis and mitochondrial diseases given the rarity of primary progressive course in paediatric MS. In the absence of an alternative diagnosis, with new therapeutic options becoming available for PPMS, this diagnosis should then be considered.
More work, better health? The moderation effect of employee-organizational psychological distance
Authors: Liu Bei , Chen Hong , Wang Yujie
Published: March 2020

Based on the data obtained from 1014 Chinese employees, this study clarified the relationship between work hours, psychological distance, and the occupational mental health of employees. This study revealed a curvilinear and almost inverted U-shaped relationship between work hours and occupational mental health. Furthermore, the results showed that the optimum interval of work hours to maintain high-quality occupational mental health was indicated as “typical overtime work,” and the employee-organizational psychological distance may positively moderate this inverted U-shaped relationship, and a “close” employee-organizational psychological distance may alleviate the pressure of work hours and help to maintain high-quality occupational mental health.
‘We are not poor things’: territorio cuerpo-tierra and Colombian women’s organised struggles
Authors: Rodriguez Castro Laura
Published: March 2020

In this article, I use Lorena Cabnal’s notion of territorio cuerpo-tierra to analyse seventeen in-depth interviews with women leaders of rural social movements and other organisations in Colombia . In the interviews, social leaders condemn violence that is epistemic, systemic, militarised and that permeates all ambits of life. They denounce how the coloniality of power operates, while at the same time they propose alternatives for a better life from their own cosmovisions by enacting food sovereignty and constructing feminisms from ‘below’. I demonstrate how these social leaders’ actions are entangled in decolonial feminist struggles, which undermine the way in which women in the Global South have been constructed as ‘objects’ or ‘in need of saving’. These women are not ‘victims who need saving’, but politically active subjects who enact change locally and nationally through their ‘territories bodies-lands’. Not only do their narratives highlight the intimate relationship of the body with the land, but I argue that we must follow their lead in order to dismantle the coloniality of power.
Over-time variation in individual’s customer satisfaction scores
Authors: Dawes John , Stocchi Lara , Dall’Olmo-Riley Francesca
Published: March 2020

Customer satisfaction is a commonly used business performance metric. Despite the widespread use of satisfaction surveys, little is known about how stable individual’s satisfaction scores are. If individual’s scores show instability, this has implications for market research design and managerial actions. To investigate the stability of satisfaction scores, this study uses data from a two-wave satisfaction survey in which the same respondents were interviewed 6 weeks apart. The respondents had no recorded purchase with the retailer between survey waves. The main finding is that only 49% of respondents give exactly the same satisfaction score on a 1–7 scale when re-surveyed. After aggregating the results into three simple categories of dissatisfied, neutral to somewhat satisfied, and satisfied, the proportions who stay in the same category from one survey to the next are 44%, 57%, and 82%, respectively, despite the overall average score for the sample staying the same. The changes in scores are a manifestation of regression to the mean, whereby those who give a low or a high score the first time tend to regress up or down toward the overall average score the next time. The main management implications are (1) interventions aimed at low or high-satisfaction customer groups need to take regression to the mean into account; (2) attempts to relate individual’s satisfaction scores to future behavior (e.g., loyalty, brand switching) should use scores averaged over two surveys; and (3) the oft-quoted belief that dissatisfied customers will tell more people compared with satisfied customers is less tenable, given that low-satisfaction scores tend to regress upward more than high scores regress down.
A Comparison of Endovascular Versus Open Repair of Popliteal Artery Aneurysms: An Updated Meta-Analysis
Authors: Tian Yu , Yuan Biao , Huang Zhiyong , Zhang Ning
Published: March 2020

Objective:

Traditionally, popliteal artery aneurysms (PPAs) were treated via open repair (OR). However, more recently endovascular repair (EVR) approaches have become more common for the treatment of PPAs. The present meta-analysis therefore sought to conduct an up-to-date review of studies comparing the relative safety and efficacy of these 2 repair strategies. To that end, patient outcomes including primary patency, operating time, hospital stay duration, and re-intervention, amputation, and graft occlusion within 30 days were compared for these OR and EVR approaches.

Methods:

Studies in which OR and EVR were compared as treatments for PPAs were identified through systematic searching of the PubMed and Embase databases. Any studies either analyzing only one of these treatments in isolation or analyzing <5 patients were not included in this analysis. For all relevant studies, patient demographic information and outcome details were compiled. Risk of bias was analyzed using a modified Newcastle-Ottawa Scale. The odds ratios, mean differences, and hazard ratios (HRs) for patient outcomes were estimated using a random-effects model.

Results:

In total, we identified 17 relevant studies including a single randomized controlled trial and 16 retrospective cohort studies, incorporating 6887 total cases (1662 EVR and 5225 OR). The quality of evidence for all measured outcomes was deemed to be very low or low according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Rates of primary patency were found to be significantly higher for patients treated via OR relative to those treated via EVR (HR = 1.60; 95% confidence interval [CI]: 1.12-2.30; P = .03). Operative and hospitalization durations, in contrast, were significantly lower for patients treated via EVR. Patients treated via EVR also experienced significantly higher rates of graft thrombosis and reintervention within 30 days relative to patients treated via OR. However, no significant differences were observed between treatments with respect to rates of patient amputation (OR = 1.01; 95% CI: 0.55-1.85; P = .98).

Conclusions:

The available data suggest that PPA repair via EVR is a safe alternative to OR, but that short-term graft thrombosis and reintervention rates are significantly greater for the former approach. Moreover, few studies to date have compared these techniques and those that were largely retrospective in nature with relatively low-quality evidence, making it difficult to make definitive statements regarding the relative safety and efficacy of these 2 repair strategies. Additional population-based large-scale studies are therefore essential in order to conduct a robust evaluation of the safety and utility of EVR as an alternative to OR for PPA repair.
Quality of Life of Latino and Non-Latino Youth With Sickle Cell Disease as Reported by Parents and Youth
Authors: Osborne Jennel C. , Green Nancy S. , Smaldone Arlene M.
Published: March 2020

Introduction

Approximately 10% to 15% of people affected by sickle cell disease (SCD) in the United States are Latino, many of whom are primary Spanish speakers. A key tool for self-reported outcome measures, the Pediatric QOL Inventory (PedsQL) SCD module, was not available in Spanish. Here, we assess the linguistic validity of a Spanish translation and compare perception of disease-specific and generic quality of life (QOL) in a sample of Latino and non-Latino children with SCD and their parents.

Method

Following forward and backward translation, Spanish-speaking child–parent dyads linguistically validated the translated instruments. Disease-specific and generic QOL perception of 28 child–parent dyads who participated in a clinical feasibility trial, HABIT (Hydroxyurea Adherence for Personal Best in Sickle Cell Disease), were compared by ethnicity. Data were analyzed by descriptive statistics, Mann–Whitney U test, absolute score differences, and minimal clinically important differences (MCID).

Results

The translated questionnaire required no further language changes. QOL scores were higher for Latino children and parents compared with non-Latinos, with score differences exceeding MCIDs for total scores and the majority of subscale scores.

Conclusion

Spanish language PedsQL SCD instruments allow measurement of QOL in Spanish-speaking Latino children with SCD and their parents. Score differences for Latinos mostly exceeded MCIDs, suggesting that these differences are clinically meaningful. Confirmation of these findings is warranted.
Do thrombolysis outcomes differ between anterior circulation stroke and posterior circulation stroke? A systematic review and meta-analysis
Authors: Lee Sang-Hun , Han Jung Hoon , Jung Ileok , Jung Jin-Man
Published: March 2020

Background

It remains unclear whether thrombolysis outcomes can be influenced by the affected vascular territory (i.e. anterior circulation stroke vs. posterior circulation stroke) in stroke patients owing to the lack of randomized controlled trials.

Aims

Using multiple comprehensive databases, we searched for observational studies of the safety and efficacy of intravenous thrombolytics and intra-arterial treatment with or without intravenous thrombolytics in accordance with the affected vascular territory. We performed a systematic review and meta-analysis. We evaluated symptomatic intracerebral hemorrhage, all-type intracerebral hemorrhage, mortality, and functional outcomes at three months. The recanalization rate was assessed in the intra-arterial treatment group.

Summary of review

Twenty-one studies including a report from our own stroke registry were included through quantitative synthesis. Compared with the anterior circulation stroke group, the posterior circulation stroke group had a lower risk of ICH, including symptomatic intracerebral hemorrhage and all-type intracerebral hemorrhage, after intravenous thrombolytics and tended to have favorable functional outcomes at three months. Mortality was similar between the two groups. Regarding intra-arterial treatment, the symptomatic intracerebral hemorrhage and post-procedural recanalization rates were comparable between the two groups, although the posterior circulation stroke group had a higher mortality risk and lower tendency for a favorable functional outcome.

Conclusions

Safety and efficacy of thrombolysis in posterior circulation stroke depends on involvement of large vessel occlusion and reperfusion modality such that intravenous thrombolytics is more effective and safer than in anterior circulation stroke; the safety and efficacy of intra-arterial treatment is comparable or lower than anterior circulation stroke. Considering the limitations of our meta-analysis, further studies are needed to provide high level evidence of a beneficial effect of intra-arterial treatment, and to identify patients’ profiles associated with benefit of treatment.
Trends and impact of three-dimensional preoperative imaging for anatomic total shoulder arthroplasty
Authors: Cancienne Jourdan M , Dempsey Ian J , Garrigues Grant E , Cole Brian J , Brockmeier Stephen F , Werner Brian C
Published: March 2020

Background

The goals of this study were to determine the incidence in the United States of preoperative three-dimensional imaging prior to anatomic total shoulder arthroplasty for osteoarthritis and to determine if preoperative imaging is associated with decreased complication rates.

Methods

Using a Medicare insurance database, we identified all patients who underwent computed tomography (n = 9380) and/or magnetic resonance imaging (n = 15,653) prior to anatomic total shoulder arthroplasty for a diagnosis of osteoarthritis from 2005 to 2014. The incidence of imaging over time was analyzed and complication rates compared between patients with imaging to matched controls.

Results

The incidence of preoperative three-dimensional imaging significantly increased over time, with computed tomography increasing more than magnetic resonance imaging. Compared to controls, patients with preoperative computed tomography imaging had significantly lower revision rates at two years (odds ratio 0.72 (0.64–0.82), p = 0.008). There were no other significant differences in the other complications studied.

Conclusions

The use of preoperative three-dimensional imaging for anatomic total shoulder arthroplasty for a diagnosis of osteoarthritis has increased dramatically, with the use of computed tomography increasing the most. Patients who underwent preoperative computed tomography imaging experienced lower revision rates at two years postoperatively compared to matched controls without such imaging.

Level of evidence

Level III, retrospective comparative study.
Underperformance of clinical risk scores in identifying vascular ultrasound-based high cardiovascular risk in systemic lupus erythematosus
Authors: Drosos George C , Konstantonis George , Sfikakis Petros P , Tektonidou Maria G
Published: March 2020

Aims

The aim of this study was to assess the performance of eight clinical risk prediction scores to identify individuals with systemic lupus erythematosus (SLE) at high cardiovascular disease (CVD) risk, as defined by the presence of atherosclerotic plaques.

Methods

CVD risk was estimated in 210 eligible SLE patients without prior CVD or diabetes mellitus (female: 93.3%, mean age: 44.8 ± 12 years) using five generic (Systematic Coronary Risk Evaluation (SCORE), Framingham Risk Score (FRS), Pooled Cohort Risk Equations (ASCVD), Globorisk, Prospective Cardiovascular Münster Study risk calculator (PROCAM)) and three ‘SLE-adapted’ (modified-SCORE, modified-FRS, QRESEARCH risk estimator, version 3 (QRISK3)) CVD risk scores, as well as ultrasound examination of the carotid and femoral arteries. Calibration, discrimination and classification measures to identify high CVD risk based on the presence of atherosclerotic plaques were assessed for all risk models. CVD risk reclassification was applied for all scores by incorporating ultrasound results.

Results

Moderate calibration ( p-value range from 0.38 to 0.63) and discrimination (area under the curve 0.73–0.84), and low-to-moderate sensitivity (8.3–71.4%) and classification ability (Matthews correlation coefficient (MCC) 0.25–0.47) were observed for all risk models to identify patients with plaques at any arterial site as high-risk. MCC was improved for modified-FRS versus FRS (0.43 vs 0.36), but not for modified-SCORE versus SCORE (0.25 vs 0.25). Based on plaque presence, CVD risk was upgraded to high-risk in 10%, 16.1%, 20.5%, 21.5%, 24%, 28.2% and 28.6% of cases classified as non-high-risk by QRISK3, modified-FRS, Globorisk, FRS/PROCAM, ASCVD, modified-SCORE and SCORE, respectively.

Conclusions

Most of the five generic and three ‘SLE-adapted’ clinical risk scores underestimated high CVD risk defined by atherosclerotic plaque presence in patients with SLE.
Association between insulin resistance and risk of atrial fibrillation in non-diabetics
Authors: Lee Yonggu , Cha Sung Joo , Park Jung-Hwan , Shin Jeong-Hun , Lim Young-Hyo , Park Hwan-Cheol , Shin Jinho , Kim Chun Ki , Park Jin-Kyu
Published: March 2020

Aims

Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. We aimed to evaluate this relationship in the nondiabetic Asian population.

Methods

Between 2001–2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident atrial fibrillation.

Results

Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14–2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1–2.5, and then plateaued afterwards (p = 0.031).

Conclusion

There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population.
Comparison of facet joint violation in lumbar posterior spinal instrumentation using different techniques including cortical bone trajectory
Authors: To CY , Cheung P , Ng W , Mok WY
Published: March 2020

Study background:

A retrospective study to compare the rate of facet joint violation (FJV) in lumbar posterior spinal instrumentation using open pedicle screw, percutaneous pedicle screw, and cortical bone trajectory (CBT) technique. CBT is a new posterior spinal instrumentation technique in which a more caudal entry point can minimize iatrogenic damage to the cranial facet joint. Only one recent study reports incidence of FJV of 11%; however, no previous reports comment on radiological outcomes comparing to traditional open and percutaneous screws.

Methods:

We reviewed 90 patients who underwent lumbar posterior spinal instrumentation from January 2016 to June 2017. Postoperative computer tomography scans were performed to evaluate FJV. Incidence of FJV was graded by three reviewers according to Seo classification.

Results:

Totally, 446 screws (open 43.4%, percutaneous 37.8%, CBT 18.9%) were inserted. Among these, 6.3% (28/446) had screw head or rod in contact with facet joint and 0.9% (4/446) had screws directly invaded the facet joint. Overall, FJV was 7.2% (CTB = 3.4%, open = 10.4%, and percutaneous = 4.5%, p = 0.075).

Conclusion:

CBT technique has potential advantage in reducing FJV. It has a unique entry site at lateral aspect of pars interarticular with a caudomedial to craniolateral pathway. It is a reasonable alternative to open or percutaneous techniques in lumbar posterior spinal instrumentation.
Not for Adults Only: Toward a Child Lens in Migration Policies in Asia
Authors: Asis Maruja M. B. , Feranil Alan
Published: March 2020

Executive Summary

Having experienced substantial international migration since the 1970s, countries in East, South, and Southeast Asia have developed laws, institutions, policies, and programs to govern various aspects of international migration. Children, however, who comprise a significant share of the world’s international migrants, have not received as much policy attention as adults. Children are part of the region’s international migration experience (e.g., children left behind in the countries of origin when their parents migrate for work, children as migrants, and children as members of multicultural families). This article provides an overview of the challenges faced by children as migration actors, and the policy responses and programs that select countries in the region have developed to address children’s experiences and concerns.

The Global Compact for Safe, Orderly and Regular Migration and the Global Compact on Refugees, which many Asian countries have endorsed, set forth objectives, commitments, and actions, informed by the principle of promoting the best interests of the child and child protection, which specifically address the needs of children. These include actions to promote universal birth registration, enhance access to education and health and social services regardless of migrant and legal status, and otherwise create inclusive and socially cohesive societies. Most countries in Asia have yet to meet these standards. Endorsing the two compacts was a first step. The good practices that have been implemented in a number of countries provide a template for how to translate these objectives into action and how to ensure that the full protection and best interests of migrant children, the left-behind children of migrant workers, and those who are part of multicultural families remain a priority.
Schooling from the classroom to the state: Understanding schools as geopolitical sites
Authors: Lizotte Christopher , Nguyen Nicole
Published: March 2020

In this paper, we make a case for situating the school as a geopolitical site. The geopolitical functions of schools and schooling have long been investigated by geographers: forming national citizens, promoting geostrategic discourses, and disciplining populations, to name a few. However, we advocate an approach that is “outward looking,” examining the school not just as a space where these functions are carried out by the state, but as a site where institutional structure, educators, and students exercise agency in complicating the actual implementation of state geopolitical aims. We do this by examining two cases where public schooling has been leveraged by Western states in the service of the post-9/11 securitization of Muslim students in the United Kingdom and France. We argue that these two cases illustrate that schools can be examined not just as containers for state policy, but as explanatory moments in their own right in understanding state geopolitical strategy.
Locating the Atrocities Against Dalits: An Analytical Approach
Authors: Prasad Devi , Bibhar S. S.
Published: March 2020

Dalits constitute around a sixth of India’s population. They have been safeguarded by the ‘Scheduled Castes and Scheduled Tribes (Prevention of Atrocities) Act, 1989’, but the adequate implementation of this special Act is in question because many instances of atrocities have been occurring consecutively. As such, this article attempts to understand the process of building a social milieu for preventing the atrocities against Dalits with particular reference to the Ganda caste. The primary data have been collected through personal narratives of the survivors along with group discussions with the villagers of Lathor in Balangir district of Odisha. Secondary sources such as Indian census reports, newspapers, websites and various constitutional provisions have also been referred to obtain an in-depth understanding of the atrocities against this marginal section.
Comparative Assessment of Widefield Fundus Autofluorescence Patterns in Retinoschisis and Retinal Detachment
Authors: Cao Jessica L. , Conti Thais F. , Hom Grant L. , Babiuch Amy S. , Greenlee Tyler , Ehlers Justis P. , Rachitskaya Aleksandra , Sharma Sumit , Yuan Alex , Kaiser Peter K. , Singh Rishi P.
Published: March 2020

Purpose:

This article characterizes widefield fundus autofluorescence (WF-FAF) patterns in retinoschisis (RS), retinal detachment (RD), and combined retinoschisis-detachment (RS/RD), and to correlate them with spectral-domain optical coherence tomography (SD-OCT) findings.

Methods:

A retrospective case series of 13 eyes with senile RS, RD, or RS/RD is presented. One eye underwent imaging of 2 areas within the retina, resulting in 14 data points. Independent, masked graders classified pathology on SD-OCT as RS, RD, or RS/RD and graded WF-FAF images for either hypoautofluorescent areas or mixed autofluorescence (AF) (hyper-AF, iso-AF, hyper-AF with hypo-AF, hyper-AF with iso-AF, or hypo-AF with iso-AF).

Results:

There was no statistically significant correlation between the autofluorescence pattern and the type of retinal abnormality ( P = .74).

Conclusions:

High variability was found in the characterization of WF-FAF in patients with RS and RD. SD-OCT remains the criterion-standard imaging modality in distinguishing RS from RD in clinically ambiguous cases.
Integrative analysis of the genomic and transcriptomic landscape of double-refractory multiple myeloma
Authors: Ziccheddu Bachisio , Biancon Giulia , Bagnoli Filippo , De Philippis Chiara , Maura Francesco , Rustad Even H. , Dugo Matteo , Devecchi Andrea , De Cecco Loris , Sensi Marialuisa , Terragna Carolina , Martello Marina , Bagratuni Tina , Kastritis Efstathios , Dimopoulos Meletios A. , Cavo Michele , Carniti Cristiana , Montefusco Vittorio , Corradini Paolo , Bolli Niccolo
Published: March 2020

In multiple myeloma, novel treatments with proteasome inhibitors (PIs) and immunomodulatory agents (IMiDs) have prolonged survival but the disease remains incurable. At relapse, next-generation sequencing has shown occasional mutations of drug targets but has failed to identify unifying features that underlie chemotherapy resistance. We studied 42 patients refractory to both PIs and IMiDs. Whole-exome sequencing was performed in 40 patients, and RNA sequencing (RNA-seq) was performed in 27. We found more mutations than were reported at diagnosis and more subclonal mutations, which implies ongoing evolution of the genome of myeloma cells during treatment. The mutational landscape was different from that described in published studies on samples taken at diagnosis. The TP53 pathway was the most frequently inactivated (in 45% of patients). Conversely, point mutations of genes associated with resistance to IMiDs were rare and were always subclonal. Refractory patients were uniquely characterized by having a mutational signature linked to exposure to alkylating agents, whose role in chemotherapy resistance and disease progression remains to be elucidated. RNA-seq analysis showed that treatment or mutations had no influence on clustering, which was instead influenced by karyotypic events. We describe a cluster with both amp(1q) and del(13) characterized by CCND2 upregulation and also overexpression of MCL1, which represents a novel target for experimental treatments. Overall, high-risk features were found in 65% of patients. However, only amp(1q) predicted survival. Gene mutations of IMiD and PI targets are not a preferred mode of drug resistance in myeloma. Chemotherapy resistance of the bulk tumor population is likely attained through differential, yet converging evolution of subclones that are overall variable from patient to patient and within the same patient.
Impacts of increasing maximum truck weight – case Finland
Authors: Liimatainen Heikki , Pöllänen Markus , Nykänen Lasse
Published: March 2020

Finnish government allowed in October 2013 operating high capacity vehicles (HCV) with a maximum weight limit of 76 t on Finnish roads. An analysis on how HCVs have affected the Finnish road freight transport sector is presented here based on a continuous time series data from 2013 to 2017. The analysis shows a significant increase in the average payload weight and a transition from 7-axle to 8- and 9-axle articulated vehicle combinations, which allow the higher weights. Truck mileage of 225 million km has been avoided from October 2013 until the end of 2017 and avoided mileage corresponded in 2017 to approximately 4% of total truck mileage in Finland. This equals around 126 million € cost savings in 2017 and 0.1 Mt of CO2 emissions reduction in road freight, even after taking into account that there has been some modal shift from rail to road.
Acceptance of mHealth among health professionals: a case study on anesthesia practitioners
Authors: Carvalho Hugo , Verdonck Michael , Forget Patrice , Poelaert Jan
Published: March 2020

Background

mHealth, the practice of medicine aided by mobile devices is a growing market. Although the offer on Anesthesia applications (Apps) is quite prolific, representative formal assessments on the views of anesthesia practitioners on its use and potential place in daily practice is lacking. This survey aimed thus to cross-assess the Belgian anesthesia population on the use of smartphone Apps and peripherals.

Methods

The survey was exclusively distributed as an online anonymous questionnaire. Sharing took place via hyperlink forwarding by the Belgian Society for Anesthesia and Reanimation (BSAR) and by the Belgian Association for Regional Anesthesia (BARA) to all registered members. The first answer took place on 5 September 2018, the last on 22 January 2019.

Results

Three hundred forty-nine answers were obtained (26.9% corresponding to trainees, 73.1% to specialists). Anesthesiologists were positively confident that Apps and peripherals could help improve anesthesia care (57.0 and 47.9%, respectively, scored 4 or 5, in a scale from 0 to 5). Trainees were significantly more confident than specialists on both mobile Apps (71.2% and 51.8%, respectively; p = 0.001) and peripherals (77.7% and 45.1%, respectively; p = 0.09).

The usefulness of Apps and Peripherals was rated 1 or below (on a 0 to 5 scale), respectively, by 9.5 and 14.6% of the total surveyed population, being specialists proportionally less confident in Smartphone peripherals than trainees (p = 0.008). Mobile apps are actively used by a significantly higher proportional number of trainees (67.0% vs. 37.3%, respectively; p = 0.000001).

The preferred category of mobile Apps was dose-calculating applications (39.15%), followed by digital books (21. 1%) and Apps for active perioperative monitoring (20.0%).

Conclusions

Belgian Anesthesia practitioners show a global positive attitude towards smartphone Apps and Peripherals, with trainees trending to be more confident than specialists.

Trial registration

ClinicalTrials.gov database Identifier: NCT03750084. Retrospectively registered on 21 November 2018.
Safety and efficacy of a standardized intracameral combination of mydriatics and anesthetic for cataract surgery in type-2 diabetic patients
Authors:   on behalf of the Intracameral Mydrane (ICMA), Ethics Group, Labetoulle Marc , Behndig Anders , Tassignon Marie-José , Nuijts Rudy , Mencucci Rita , Güell José Luis , Pleyer Uwe , Szaflik Jacek , Rosen Paul , Bérard Alain , Chiambaretta Frédéric , Cochener-Lamard Béatrice
Published: March 2020

Background

Cataract surgery in diabetics is more technically challenging due to a number of factors including poor intraoperative pupil dilation and a higher risk of vision threatening complications. This study evaluates the safety and efficacy of an intracameral combination of 2 mydriatics and 1 anesthetic (ICMA, Mydrane) for cataract surgery in patients with well-controlled type-2 diabetes.

Methods

Post-hoc subgroup analysis of a phase 3 randomized study, comparing ICMA to a conventional topical regimen. Data were collected from 68 centers in Europe and Algeria. Only well-controlled type-2 diabetics, free of pre-proliferative retinopathy, were included. The results for non-diabetics are also reported. The primary efficacy variable was successful capsulorhexis without additional mydriatic treatment. Postoperative safety included adverse events, endothelial cell density and vision.

Results

Among 591 randomized patients, 57 (9.6%) had controlled type 2 diabetes [24 (42.1%) in the ICMA Group and 33 (57.9%) in the Topical Group; intention-to-treat (ITT) set]. Among diabetics, capsulorhexis was successfully performed without additional mydriatics in 24 (96.0%; modified-ITT set) patients in the ICMA Group and 26 (89.7%) in the Topical Group. These proportions were similar in non-diabetics. No diabetic patient [1 (0.5%) non-diabetics] in the ICMA Group had a significant decrease in pupil size (≥3 mm) intraoperatively compared to 4 (16.0%; modified-ITT set) diabetics [16 (7.3%) non-diabetics] in the Topical group. Ocular AE among diabetics occurred in 2 (8.0%; Safety set) patients in the ICMA Group and 5 (16.7%) in the Topical Group. Endothelial cell density at 1 month postoperatively was similar between groups in diabetics (P = 0.627) and non-diabetics (P = 0.368).

Conclusions

ICMA is effective and can be safely used in patients with well-controlled diabetes, with potential advantages compared to a topical regimen including reduced systemic risk, better corneal integrity and reduced risk of ocular complications.

Trial registration

The trial was registered at (reference # NCT02101359) on April 2, 2014.
Study protocol for the DEFENDD trial: an RCT on the Dynamic Locking Blade Plate (DLBP) versus the Dynamic Hip Screw (DHS) for displaced femoral neck fractures in patients 65 years and younger
Authors: Kalsbeek J. H. , Roerdink W. H. , Krijnen P. , van den Akker-van Marle M. E. , Schipper I. B.
Published: March 2020

Background

The Dynamic Locking Blade Plate (DLBP) was recently introduced for fixation of displaced femoral neck fractures (FNF) and has been well received. Although the results of this implant in young patients are promising, the DLBP has not yet been compared to a standard device such as the Dynamic Hip Screw (DHS). The aim of this study is to compare the clinical outcome and costs of displaced FNF treated with internal fixation by means of either the DLBP or the DHS in patients up to 65 years of age. We hypothesize that the DLBP is superior compared to the DHS in terms of revision surgery rate, union rate, incidence of avascular necrosis and implant related failure.

Methods

The DEFENDD (DisplacEd Femoral Neck fractures Dlbp versus Dhs) trial is a multicentre randomized controlled trial that will include 266 patients of 18–65 years with a displaced FNF. Patients will be randomized to receive either a DLBP or a DHS with a 1:1 allocation using a random block size, stratified for centre. Clinical follow up will last 1 year and questionnaires will be obtained up to 2 years. The main outcome parameter is the incidence of revision surgery within 1 year, due to either non-union, avascular necrosis (AVN) or cut out of the implant. Secondary study parameters are the incidence of avascular necrosis, non-union, (implant related) complications, functional outcome, elective removal of the implant and health-related quality of life and costs.

Discussion

The outcome of the DEFENDD trial will provide high-level evidence of which implant is favourable for the treatment of femoral neck fractures in young patients (≤65 years).

Trial registration

Netherlands Trial Register, NL7300 Registration date 25-09-2018.
Beta-catenin inhibits bovine parainfluenza virus type 3 replication via innate immunity pathway
Authors: Du Xinying , He Wenqi , He Hongbin , Wang Hongmei
Published: March 2020

Background

Bovine parainfluenza virus type 3 (BPIV3) is one of the important viral respiratory agents associated with the bovine respiratory disease complex (BRDC) in cattle. Previous study has demonstrated that infection of BPIV3 causes innate immune response within the host cell. β-catenin is a key component of the Wnt/β-catenin signal pathway which is involved in the regulation of interferon-beta (IFN-β) transcription. Some viruses can activate while others can inhibit the Wnt/β-catenin signaling pathway. However, the role of β-catenin in BPIV3 infection remains unclear.

Results

Here we found that the expression of β-catenin mRNA was up-regulated and β-catenin protein was down-regulated after BPIV3 infection in MDBK cells. Moreover, it was confirmed that overexpression of β-catenin suppressed BPIV3 replication and knockdown of β-catenin promoted viral replication, suggesting that β-catenin inhibits BPIV3 replication. Furthermore, IFN-β signal pathway and virus titer analysis using the GSK3β inhibitor (LiCl) revealed that Wnt/β-catenin can serve as a mechanism to suppress virus replication in infected cells. The results indicated that LiCl promoted the expression and accumulation in the nucleus of β-catenin, which further promoted the expression of IFN-β and OSA1 and suppressed BPIV3 replication. Most importantly, BPIV3 down-regulating β-catenin protein expression was due to degradation of GSK3β mediated proteasome pathway.

Conclusions

In summary, we discovered the relationship between β-catenin and BPIV3 replication. These results provided further insight into the study of BPIV3 pathogenesis.