bluuebunny/crossref_metadata_2025 huggingface dataset:
Crypto your Belongings by Two Pin Authentication using Ant Algorithm based Technique
Authors: Palaniappan Janaki Raman
Published: July 2022

Everyone realize data is one of the important strategic for any company to run and win the business. Let it be a mobile apps, websites and so on, there are more chances that our personal data like images, videos, texts get expose while we share across for different purposes. Even though the company says app, website forms are encrypted, the said company itself uses the data internally for their business development. This research presents how one can secure own’s data themselves before sending. There are many cryptography methods that has evolved from time to time. Upon researching and analyzing, I present a unique method to encrypt and decrypt the data, using combination of techniques such as Cryptographic technique, ANT Algorithm based formula and logic gates that would provide stronger protection to the data. Secure your images, videos with a 2-pin authentication and protection to encrypt and decrypt the data. A user must provide 2 different symmetric pins to encrypt and decrypt, where first pin shall be up to 4-digit secret pin and a second pin is a single digit pin. Single digit pin acts on how many stages the encryption takes place. The proposed method had been experimented on several images and videos. This study reveals, A combination of secret keys, ANT algorithm and Logic gates makes difficult for anyone to hack the data. This unique methodology helps us to protect our data more safely at source device itself.
A Summary of Covid-19 Datasets
Authors: Bashir Syed Raza , Raza Shaina , Thakkar Vidhi , Naseem Usman
Published: July 2022

This research presents a review of main datasets that are developed for COVID-19 research. We hope this collection will continue to bring together members of the computing community, biomedical experts, and policymakers in the pursuit of effective COVID-19 treatments and management policies. Many organizations, such as the World Health Organization (WHO), John Hopkins, National Institute of Health (NIH), COVID-19 open science table and such, in the world, have made numerous datasets available to the public. However, these datasets originate from a variety of different sources and initiatives. The purpose of this research is to summarize the open COVID-19 datasets to make them more accessible to the research community for health systems design and analysis. We also discuss the numerous resources introduced to support text mining applications throughout the COVID-19 literature; more precisely, we discuss the corpora, modelling resources, systems, and shared tasks introduced for COVID-19.
ChatForSenior: An Intelligent ChatBot Communication System for Depression Relief using Artificial Intelligence and Natural Language Processing
Authors: Mai Hanwen , Sun Yu
Published: July 2022

In recent years, loneliness has appeared in lives for both young and old individuals. As cases of the COVID-19 virus are going up people have dealt more with loneliness and depression especially the seniors [5]. Some have even changed their whole lifestyle because they feel empty and isolated. Others will either try to isolate themselves more or use dangerous ways to quickly get rid of the feeling.To solve this major problem, I have created a digital online communication app which young individuals can have long chats with seniors who are alone and lonely. My application uses real time communication systems which can directly be sent to other users without any issues [6]. Our main goal is to have users have their own way of communicating, using familiar designs of applications we all have used before. By using new features we have created a more user-friendly based user experience which can be experienced throughout our application. Using immersive layouts of applications designs, advanced network connections, visual and data based analytic we are able to solve this major problem.
Detecting Depression in Social Media using Machine Learning
Authors: Ding Ruoxi , Sun Yu
Published: July 2022

Social Media Depression Detection is an Intelligent System to automate the detection of Youth Depression with social media (Instagram) using AI and Deep Learning. The student is the targeted group because most students with depression express themselves on social media rather than seeking help from doctors. This app gathers captions and images from the user's personal Instagram profile through web scraping using Instagram private API to check whether or not the posts are depressive. The google cloud dataset supports the captions and pictures analysis performed by the app [6]. Caption sentiment analysis depends on sentiment analysis, and the pictures analysis depends on classifying images by custom labels. The app reports the image and the caption analysis results back to the user. Python is used for the back-end functionality, while Dart and Flutter are used for the front-end. It was tested by 2 experiments, the first experiments returned the feedback of 15 students demonstrates that the program has the capability of detecting depression through the captions with relatively high accuracy. The second experiment of testing the app functionality on the same account demonstrates that the program is stable and consistent. The purpose of the app is to detect depression at an early stage to prevent the condition from worsening.
¿Es factible que el bitcoin alcance un millón de dólares en 5 años?
Authors: Acevedo Carlos
Published: July 2022

En este artículo se examina qué tan factible es que el precio del Bitcoin alcance un millón de dólares dentro de cinco años. Este es un supuesto clave para el éxito de la emisión de mil millones de dólares en bonos Bitcoin que el presidente salvadoreño Nayib Bukele anunció en noviembre de 2021. El artículo examina el ecosistema de la billetera digital Chivo y el contexto en el que se enmarca la emisión de los bonos Bitcoin. Muestra que, aplicando modelos convencionales de pronóstico de series financieras, es poco probable que pueda alcanzarse esa meta. Y si bien es cierto que es posible encontrar una función matemática de tipo exponencial consistente con la meta, económicamente parece poco factible alcanzarla.
Realidad Empresarial No. 13, 2022: 8-21.
Panorama de la gestión financiera de los emprendedores y empresarios salvadoreños después de la pandemia
Authors: Medrano López Betsabé Raquel , Alegría Ascencio Daniel Enrique , Sosa Ramos Hugo Stanley , García Nieto Loida Jeannette
Published: July 2022

La gestión financiera, clasificada en actividades de operación, inversión y financiamiento, permite al analista financiero tomar decisiones a mediano y largo plazo que afectan directamente el rumbo de la empresa. Así mismo, estas decisiones permiten evaluar y analizar la rentabilidad y liquidez financiera en un momento determinado, por lo que en estos últimos años tanto emprendedores como empresarios han tenido que ser resilientes para superar la situación económica efecto de la pandemia por COVID-19. Bajo este contexto, este artículo busca dar un panorama de la visión a futuro del sector de emprendimientos y Micro, Pequeña y Mediana Empresa (MIPYMES) salvadoreñas.
Realidad Empresarial No. 13, 2022: 44-51.
Principios necesarios en torno a la deconstrucción en el marketing
Authors: Molina Aguilar Jorge Manuel , Alvarado Palacios Judit Isabel , Perla Cartagena Ana Evelyn
Published: July 2022

Este artículo es la segunda parte de un trabajo titulado “Principios necesarios en torno a la deconstrucción en el marketing: Primera Parte” que a su vez forma parte de un texto más extenso “El Salvador y los estereotipos de la mujer que prevalecen en su publicidad televisiva” investigación publicada en la revista Realidad Empresarial en julio del 2020. Este texto se enfoca en analizar la necesidad de una deconstrucción de las ideas tradicionales alrededor del marketing como una profesión y disciplina insidiosa y negativa, sobre todo desde expresiones que reproducen estereotipos de género y violencia simbólica que son, al mismo tiempo, la materialización de un conjunto de estrategias representativas en los sistemas de consumo y la cadena de producción. El estudio se desarrolló desde una propuesta metodológica de tipo cualitativo, y su técnica de recolección fue una revisión bibliográfica no sistemática y grupos focales. Los resultados muestran que profesionales de marketing y consumidores finales no identifican estereotipos de género y expresiones de violencia simbólica en piezas gráficas de publicidad. Tanto los profesionales del marketing responsables de la toma de decisiones como consumidores finales identifican roles femeninos presentes en la publicidad analizada, pero esta descripción coincide con un estereotipo de género, aunque no los clasifican como roles femeninos negativos ni como violencia simbólica contra la mujer. A partir de estos resultados, el texto propone una reconstrucción del quehacer del marketing desde una visión ética que debe construirse en diferentes contextos educativos -no solo el aula o en la interacción docente-estudiantes-, y a través de la pedagogía y la macro didáctica.
Realidad Empresarial No. 13, 2022: 22-43.
Jurisdiction Issues in Cyberspace: An Overview in Respect of Brunei and Malaysia Compared to The United States’ System
Authors: AHMAD Nehaluddin , ZULKIFFLE Norulaziemah
Published: July 2022

Cyberspace is a borderless world. It refuses to accord geopolitical boundaries. This means that cyberspace has no physical boundaries and limitations. Despite the benefits it offers, it places a unique challenge for states mainly on the issue of jurisdiction and sovereignty.
Evidence of the Long-term Influence of Local Regulations as a Challenge to the International Harmonization of Financial Reporting
Authors: ALBUQUERQUE Fábio
Published: July 2022

The study aims to assess the potential long-term effects of the ‘accounting culture’ sedimented in POC on the materialization of the concepts in IAS and IFRS. Through the archive research as a method, the contents of the consolidated reports of the entities listed in the main Index of Euronext Lisboa for the most recent year (2020 or 2021, when available) were assessed.
The Indonesian Investors’ Responses toward ERM Disclosure
Authors: Pratama Andria Puja , Dalimunthe Zuliani , Wasilah Wasilah , Hadisumarto Aswin Dewanto , Sulistyarini mbuh , Haikal Shalahuddin
Published: July 2022

In Indonesia, enterprise risk management (ERM) disclosure is mandatory and is expected to be substantial risk mitigation for investors. However, it becomes a question of whether the investors respond positively to ERM disclosure. ERM implementation requires the company's resources that should impact its profitability.
E-Commerce during the COVID 19 Pandemic in the context of Investor Decision-Making
Authors: CERNY Matej , HAMRANOVA Anna , ROMANOVA Anita , TOROKOVA Aniko
Published: July 2022

Putting measures in place to eliminate the spread of the COVID-19 pandemic has significantly contributed to the transfer of human activities to the online environment, thereby contributing to the increase in the use of e-commerce. The main goal of our research was to identify whether the field of e-commerce is a suitable object for investors in Slovakia.
The Motivation of Generations: What Drives Generation X, Y, Z?
Authors: BIELIŃSKA-DUSZA Edyta
Published: July 2022

Generations X, Y, and Z are shaped by different groups which, at the stage of developing their personality, prepared for work and entered the labor market under various socio-economic conditions.
ANALISIS REMBESAN DAN STABILITAS BENDUNGAN SARADAN
Authors: Saidillah Muhammad , Kusuma Artati Hanindya
Published: July 2022

Bendungan Saradan merupakan salah satu bendungan yang terletak di Kecamatan Saradan, Kabupaten Madiun, Provinsi Jawa Timur. Bendungan Saradan dibangun antara tahun 1942 oleh Pemerintah Hindia Belanda, oleh karena itu untuk mengetahui keamanan bendungan perlu ditinjau rembesan dan kestabilan badan bendungan saat ini. Penelitian ini menggunakan metode Casagrande untuk menganalisis rembesan yang terdapat pada tubuh bendungan dan metode Bishop untuk menganalisis stabilitas tubuh bendungan dengan menambahkan faktor koefisien beban gempa OBE (Operating Basis Earthquake) dan MDE (Maximum Design Earthquake). Dalam penelitian ini digunakan Program GeoStudio 2012 untuk menganalisis rembesan dan stabilitas badan bendungan pada kondisi muka air banjir, muka air normal, muka air minimum, dan penarikan cepat. Hasil analisis menggunakan Geostudio 2012 menunjukkan bahwa faktor keamanan untuk kestabilan badan bendungan Saradan ada pada kondisi dengan muka air banjir tanpa gempa 6,005 > 1,5 (Aman), dengan angka gempa OBE 3,452 > 1,5 (Aman ), dengan angka gempa MDE 1.457 > 1 (Aman), kemudian pada kondisi muka air normal tanpa gempa 5.037 > 1,5 (Aman), dengan gempa OBE 3.124 > 1,2 (Aman), dengan angka gempa MDE 1.407 > 1 (Aman), maka di kondisi muka air minimum tanpa gempa 2.541 > 1,5 (Aman), dengan angka gempa OBE 2.031 > 1,2 (Aman), dengan angka gempa MDE 1.245 > 1 (Aman), kemudian pada kondisi drawdown tanpa gempa 1,899 > 1,3 (Aman), dengan gempa OBE 1,541 > 1,1 (Aman), dengan angka gempa MDE 0,973 > 1 (Aman). Analisis rembesan pada bendungan Saradan setelah dilakukan perhitungan manual dan hasil analisis program GeoStudio 2012 menunjukkan dalam setiap kondisi aman.
ANALISIS Faktor PENYEBAB KECELAKAAN RUAS JALAN LIMBANGAN MALANGBONG KABUPATEN GARUT
Authors: Hernawan Hernawan
Published: July 2022

Accidents are unplanned and uncontrolled actions, when the action and reaction of objects, materials or radiation will cause injury or Possible injury Jalan Malangbong – Limbangan is the National route which is located on the southern route of West Java. The results of the analysis showed that the largest percentage of traffic accidents on the Malangbong Limbangan road from 2015 - 2020, the largest number of accident victims was 2015 by 33% of the number of accident victims, the placeor location of the accident occurred 63% at bends during the period 2015 - 2020, based on the type of collision by 42% when overtaking, accidents based on the most road users are motorcycles with the largest percentage from 2015 - 2020 by 58%, and 79% occurring in areas around residential areas, the largest time of occurrence is from 06.00 - 15.00 at 55 % and the main factors causing traffic accidents from year 2015 – 2020 is an environmental factor of 63% which occurs in corners due to blocked visibility and bumpy road surfaces due to heavy vehicle loads and the number of road surfaces that are temporarily repaired with patches
Development of Economic Learning Innovation Using Lectora Inspire Media on Demand and Supply Materials for Class X Muhammadiyah Senior High School 2 of Kertosono
Authors: Kayal Rajarshi , Banik Krishanu , Kayal Saheli
Published: July 2022

Hypogonadism in female is one of the causes of menstrual irregularities and infertility. This clinical syndrome is characterized by decreased sex steroid secretion either due to primary gonadal failure or secondarily due to central hypothalamic-pituitary causes. In our study, it is found that patients with diabetes have primary ovarian failure with low estradiol and high FSH, LH values.
[Learning media, Lectora Inspire, Computer Hardware]
Analysis of the Effect of Work-Life Balance on Employee Engagement Employees PT. XYZ
Authors: Siregar Tumpal PM , Nasution Harmein , Absah Yeni
Published: July 2022

Employee engagement has become an interesting topic in the discussion of organizational behaviour in recent years. Amid increasingly fierce company competition, it is very necessary for engaged employees, employee engagement can create success for the company through several things, one of which is related to employee performance and makes employees have higher loyalty to reduce the desire to leave the company (turnover intention). Employee engagement will appear when employees have a high level of work-life balance. Work-life balance can be described as a condition when a person can share roles and feel satisfaction in these roles as indicated by low levels of work-family conflict and high levels of work-family facilitation or work-family enrichment. In other words, work-life balance is an aspect that must appear first in employees before employees feel engaged. When employees have a high level of role satisfaction, employees will give more time, energy and initiative to be able to contribute to the company. This study uses a descriptive type of research with a quantitative approach. The nature of this research is explanatory research which is research that explains the position of the variables studied and the relationship between the work-life balance variable and the employee engagement variable. The subjects in this study were employees of PT. XYZ, totalling 71 people. The measuring instrument used in this study is a scale, namely the employee engagement scale and work-life balance scale which is based on the employee engagement dimension by Anitha (2014) and the work-life balance aspect by Fisher, Bulger and Smith (2009). The data analysis technique used in this study uses Smart PLS (Partial Least Square) software. Based on the results of the analysis and discussion, it can be concluded that work-life balance has a positive and significant effect on employee engagement. The effective contribution of the work-life balance variable is 49.5% to employee engagement. The results of this study then become the basis for determining interventions in the form of training to improve work-life balance which will ultimately increase employee engagement in employees.

Keywords: employee engagement, work-life balance.
Psychological Impacts and Coping Mechanisms of 4th District of Camarines Sur, Philippines during the Community Quarantine due to Corona Virus Disease (COVID-19)
Authors: Palmes-Barcela Marilou
Published: July 2022

To determine the psychological impact and coping mechanisms of selected group of residents in the 4th District of Camarines Sur during the Community Quarantine due to COVID 19, this study was conducted. This a descriptive research and questionnaire was prepared and adopted the Self-Reporting questionnaire developed by World Health Organization (WHO); and the impact of Events Scale –Revised (IES-R). Findings revealed that students were high in terms of neurotic, psychotic and post-traumatic stress disorder (PSTD). Among these three, post-traumatic stress disorder (PSTD) was the highest at 76.81 % among students. Male recorded the highest compared to female. Symptoms were avoidance, intrusion and hyper arousal. Generally, they had experienced moderate symptoms. The respondents were with their family and stayed at home, generally felt sad and their top most coping mechanisms were praying, listening to music/singing, and connecting with others thru social media. Local governments and barangays provided support such as rice, grocery items and facemasks which in a way helped cope the impact of community quarantine. Some were happy and some were not due to some issues on the system of distribution. Various recommendations were given to improve the system and to cope with the impact of the community quarantine, that the local government and barangay officials must come up with the concrete programs and budget, specific focus on the distribution, prioritization of recipients, immediate response, protocols, recreational, wellness, moral and financial support to boost the morale and avoid the adverse effect of community on the health condition of the residents.

Keywords: psychological impact, coping mechanism, COVID- 19 pandemic, community quarantine, barangay and government support.
Herbal Wealth of the Coastal Village of Melmidalam, Tamilnadu, India
Authors: Starlin.N Maybel
Published: July 2022

The district of Kanyakumari lies at geographical co-ordinates between 77° 15' and 77° 36' east and 8° 03' and 8° 35' north. The district is located at the southerly point of Peninsular India. Kanyakumari district is often cited as 'Land's end'. Kanyakumari has 504.86 sq.km. of government forests which can be calculated as 30.2 percent of the total area of the territory. The average rainfall of the district is 1456.8 mm per annum. Unlike other districts in Tamil Nadu, Kanyakumari receives a fairly good rainfall from both southwest and northeast monsoons. Kanyakumari coastal line has a length of about 71.5 km. Melmidalam is a coastal Village on the shore of the Arabian Sea in Kanyakumari district, Tamil Nadu, India. It is situated near the border of Tamil Nadu and Kerala. This village is the part of Midalam Panchayat of Killiyoor Block, Vilavancode taluk. Coastal region is an ecological storehouse of biodiversity. The plants are playing a vital role in protecting the coast from erosion and flooding. These coastal villages have a population of 1, 48,539 fishermen, forming 19 percent of the total fisherman population (7, 90,408) in Tamil Nadu. The potential availability of medicinal plants in wild areas is threatened by rising use and overexploitation, which raises concern about their conservation. Hence the present study was undertaken to document the ethnomedicinal knowledge of Melmidalam village, to assess the medicinal plant diversity of the coasts and to enumerate information about morphologically useful parts of the medicinal plants to cure various ailments.

Keywords: Ailments, biodiversity, ethnomedicinal knowledge, Melmidalam..
Enhancing Employee Performance in the Water Sector in South Africa: The Role of Training and Skill Development Programmes
Authors: Kwame Adom Richard , Simatele Mulala Danny
Published: July 2022

Training and development are regarded as essential tools for any organisation to achieve its goals. It is widely acknowledged that many institutions invest in their employees' development to enhance their performance and improve productivity. Nevertheless, many institutions in South Africa, including the water sector, regard training and staff development as needless expenditure and often do little to augment their employees' knowledge and skills resulting in lower outputs and a dissatisfied population. Based on these challenges, this paper employed the purposive sampling technique to draw a sample of 100 out of a total of 300 employees from the water sector in four provinces to analysed whether training and development is relevant in enhancing employees’ performance in the water sector. The findings revealed that training and development is not a priority in the sector, and that there are no strategic planning or policy guidelines for staff development. It was further found that training programmes in the sector is bedevilled with both systemic and structural challenges. This paper, therefore, recommend integrative approach to the training of employees and carefully thought-out programmes that identify employees’ weaknesses and introduce strategies that will enable the employees to enhance their skills and expertise at a minimum cost.

Keywords: Training, Development, Performance, Public Sector Employees, Water Department .
The Effect of the Environment and Work Stress on Employee Performance
Authors: . Toton , Saptarini Veronica
Published: July 2022

Human resource management is a process that handles various problems within the scope of employees, employees, laborers, managers and other workers to be able to support the activities of the organization or company in order to achieve predetermined goals. In this case, a good environment and the stress of pressure at work can be factors that affect the performance of employees. This research was conducted to find out how influential it is on employee performance at Perum Bulog, Regional Office of Lampung. With the number of samples used as many as 43 employees. The analytical technique used in this study is Validity, Reliability, and Multiple Linear Regression. The results of this study are the influence of the Work Environment on Employee Performance by 29%, then the effect of Work Stress on Employee Performance by 30%, and the influence of the Environment Work and work stress on employee performance is 41%, which means that work environment and work stress have an important role in improving employee performance at Perum Bulog, Lampung Regional Office.

Keywords: Work Environment, Work Stress, Employee Performance, Bulog.
Concept and Management of Bahaq
(Pityriasis Versicolor) in Unani Medicine - A Review
Authors: Akhter Farzana , Quamri M. A. , Bashir Sabreena
Published: July 2022

Pityriasis versicolor also called Tinea versicolor (Bahaq) is a superficial fungal infection of the skin characterized by hypo or hyperpigmented macules or patches on upper trunk and neck. Most commonly affects adolescents and young adults.According to Unani system, it is humoral disease characterized by alteration in the quality or quantity of phlegm or black bile, resulting in hypo or hyperpigmentation. The treatment of bahaq has been extensively studied in Unani medicine by ancient scholars such as Rabban Tabarī, Zakariya Razi, Ibn Sina, Ajmal Khan and various others have described drugs single as well as compound formulations for its treatment. This review paper is intended to highlight the concept and various treatment methods of Unani in the management of Bahaq

Keywords: Pityriasis versicolor, Tinea Versicolor, Bahaq, Unani medicine.
Recruitment and Selection Strategy to Capture Agility Talent at PT. XYZ
Authors: Cahyadi Harsak Hery , Nasution Harmein , Absah Yeni
Published: July 2022

In the era of globalization and fierce competition in the business world, every company must improve its business performance, and one of the company's efforts to improve its business performance is to have human resources who have the ability and talent agility which is one of the factors causing the company's success. The purpose of this research is to explain the recruitment and selection strategy that can be used by PT. XYZ to recruit prospective employees who have agility talent, how the recruitment and selection strategy is and the characteristics and indicators of prospective employees who have agility talent. The method used in this research is descriptive qualitative, with data collection techniques using interviews and documentation. The results of the study show that using a recruitment and selection strategy to capture agility talent can show significant results. One of the strategic recruitment and selection processes is interviews using the Iceberg method and looking for and attracting prospective employees from well-known university students who have many potential candidates and attracting candidates in companies that are known to have qualified and competent employees, so that recruitment and selection will be more effective and efficient which will enable the company to be able to compete, survive and excel in the face of future competition and business competition as well as uncertain business conditions.

Keywords: Strategy, Recruitment, Selection, Talent Agility.
Avaliação de alterações germinativas em MUTYH em pacientes com câncer colorretal e mutação somática KRAS G12C
Authors: Medeiros Ana Beatriz Deleame , Da Silva Sara Iolanda Oliveira , Da Rocha José Claudio Casali , Aguiar-Junior Samuel , Carraro Dirce Maria , Torrezan Giovana Tardin
Published: July 2022

Introdução: A Polipose Associada ao gene MUTYH (MAP) é uma síndrome recessiva causada por mutações bialélicas em MUTYH, as quais inativam o gene e levam a uma alta ocorrência de transversões G:C à T:A, gerando a mutação KRAS c.34G>T; G12C. A mutação ocorre em menos de 5% dos casos de câncer colorretal (CCR) esporádicos, mas é altamente frequente em CCR de pacientes MAP. Objetivo: O objetivo do estudo é avaliar a taxa de detecção de variantes germinativas patogênicas/provavelmente patogênicas em MUTYH em pacientes com CCR e mutação somática KRAS G12C. Metodologia: Avaliaremos 3 variantes patogênicas de MUTYH (p.Tyr179Cys, p.Gly396Asp e deleção dos éxons 4 a 16) por PCR multiplex, eletroforese e sequenciamento de nova geração (NGS). Pacientes com 1 variante em heterozigose serão submetidos ao sequenciamento completo do MUTYH. As características clínicas e anatomopatológicas dos pacientes serão correlacionadas com resultados que serão descritos estatisticamente. Resultados preliminares: Até o momento foram identificados 121 pacientes com CCR mutação KRAS c.34G>T; G12C com média de idade de 59 anos, dos quais 51 apresentavam história familiar positiva (42,14%) e 46 apresentavam ao menos 1 pólipo (38,01%). Para 39 pacientes identificamos disponibilidade de material no Biobanco da instituição. Em análises prévias, avaliamos 9 pacientes com CCR antes dos 50 anos e identificamos 3 (33%) com alteração em MUTYH, sendo 2 com variantes patogênicas em ambos os alelos e 1 com uma variante patogênica e uma de significado incerto (VUS). Conclusão: Esperamos verificar se pacientes com CCR mutação somática KRAS G12C apresentam maior risco de detecção de variantes germinativas patogênicas no gene MUTYH, podendo-se utilizar dos resultados da detecção da mutação em KRAS como um teste pré-triagem para diagnóstico da MAP.
Análise cinética dos perfis de citocinas esplênicas de camundongos Balb/C induzidos a desenvolver tumor de mama com células 4t1 e submetidos a imunoterapia de células dendríticas
Authors: Gomes Eleni Solange de Brito , Da Silva Saulo Fernando Moreira , Michelin Márcia Antoniazi
Published: July 2022

Introdução: O câncer de mama, por ser uma das doenças que mais mata mulheres, merece uma atenção mais do que especial. Os linfócitos T auxiliares e seus subtipos Th1, Th2, Th17 e Treg possuem funções importantes e diferenciadas, para uma resposta imune adequada. Utilizados como fator prognostico em diferentes tipos de tumores, os mesmos produzem diversas citocinas que atuam tanto na regressão como também no desenvolvimento tumoral. Objetivo: Mensurar nos dias 07 e 14 as citocinas (IL-2, IL-4, IL-10, IL-12, TNF-α, TGF-β e IFN-γ) produzidas ex vivo por esplenócitos de camundongos BALB/c induzidos a desenvolver tumor de mama com células 4T1 e submetidos a imunoterapia com células dendríticas comparando com animais não tratados. Relacionar as mudanças nos níveis de produção das citocinas com o volume tumoral. Metodologia: Realizou-se a técnica de ELISA, utilizando o sobrenadante de cultura de células do baço de cinco grupos: Controle, Tumor 7 dias, Tumor DC 7 dias, Tumor 14 dias e Tumor DC 14 dias. Os dados obtidos foram analisados no GraphPad Prism 8 e foram considerados estatisticamente significativos com p<0.05. Resultados: Com 7 dias de tratamento tivemos um aumento da IL-2 e da IL-10, diminuição da IFN- γ, IL-4 e da TGF-β quando comparados com o grupo Tumor 7 dias sem tratamento. Obteve-se também diminuição da IL-2, IL-4, IL-10, TNF-α, TGF-β, e aumento da IFN-γ quando comparado o grupo Tumor 14 dias com o grupo Tumor DC 14 dias. Houve mudança nos níveis de produção de citocinas nos grupos analisados, mas não se teve um padrão dessa produção, quando comparado o grupo Tumor DC 7 dias com o grupo Tumor DC 14 dias. Conclusão: Os resultados demostraram que aos 14 dias de tratamento a produção de citocinas que atuam de forma antitumoral é mais prevalente, o que implica numa maior regressão tumoral.
Tumores de células germinativas não-seminomatosos: insights da transição epitelial-mesenquimal
Authors: Ramos Lorrayne Pereira , Rosa Marcela Nunez , Lengert André Van Helvoort , Cabral Eduardo Ramos Martins , Gomes Izabela Natalia Faria , Galvão Janaina Mello Soares , Evangelista Adriane Feijó , Lopes Luiz Fernando , Reis Rui Manuel Vieira , Pinto Mariana Tomazini Pinto
Published: July 2022

Tumores de Célula Germinativa (TCGs) são neoplasias benignas ou malignas, classificadas em diferentes histologias: seminomas, não seminomas (teratomas, seio endodérmico, carcinomas embrionários e coriocarcinoma). Dentre os hallmarks of cancer encontra-se a transição epitélio-mesenquimal (EMT), processo no qual as células epiteliais perdem suas características e adquirem fenótipo mesenquimal. A EMT pode ser induzida por diversos fatores, sendo SNAIL e SLUG os protagonistas. A EMT foi associada com diversos canceres, entretanto, há uma escassez de informação da EMT nos TCGs. O objetivo foi avaliar a EMT em diferentes tipos histológicos de TCGs. Foi realizada uma análise in silico, utilizando as plataformas cBioPortal, Oncomine, PAXdb, para avaliar a expressão dos marcadores da EMT em pacientes com TCGs. Os marcadores da EMT também foram avaliados por qPCR e WB em diferentes linhagens de TCGs: carcinoma embrionário (NTERA-2 e 1777N), coriocarcinoma (JEG-3) e teratoma malígno (577MF). As análises in silico revelaram que SNAIL possui maior abundância de proteína no organismo do que SLUG. Contudo, SLUG possui impacto significativo na sobrevida livre de doença. Os tumores não-seminomatosos possuem maior expressão dos marcadores da EMT comparado com os seminomatosos. Dentre os não-seminomatosos, os teratomas apresentaram maior expressão dos marcadores da EMT. As análises in vitro confirmaram os resultados e a linhagem 577MF apresentou menor expressão E-CADERINA e superexpressão de SNAIL, VIMENTINA, FIBRONECTINA, TGF-β, e N-CADERINA. Portanto, a expressão dos marcadores da EMT em TCGs varia de acordo com a histologia, sendo mais expressos em teratomas. Maiores investigações são necessárias para avaliar o papel desses fatores em TCGs.
An Assessment of the Living Conditions of School Teachers during the Covid-19 Lockdown in Nigeria
Authors: Ebikaboere Omu Ruth , Egerson Daniel
Published: July 2022

The COVID-19 outbreak in parts of the world has not only created gaps for students in learning but also widened the survival gaps for school teachers who depend largely on their income. This study assessed the living conditions of private school teachers during the pandemic lockdown in Nigeria. The study adopted a cross-sectional survey using an online questionnaire for respondents across major cities. The study employed descriptive statistics in examining remuneration received before and during the lockdown, sources of survival for respondents without salaries, feeding pattern and access to stimulus packages/palliatives during the lockdown. A snowball sampling technique was used in recruiting 1,144 respondents for the study. As part of the findings of the study, the mean age of respondents was 33.6 with majority being single. Over 60% of the respondents were not paid salaries during the lockdown leading a higher reliance on family support during the pandemic lockdown. There were changes in the number of meals consumed per day, from 66% with 3 meals before the lockdown to 41% shifting to 1 meal a day during the lockdown. It was also gathered that stimulus packages in form of palliatives were not accessed by 74% of the respondents. Although, there was no significant relationship between gender and the palliatives received with p-value at 0.080, majority of the palliative received were from individual sources rather than the government. The study findings suggests that the present conditions tend to discourage teachers already in private schools and would likely affect the decisions of prospective teachers in the future.
Dropout Problem of the Scheduled Caste Students in West Bengal: A Geographical Analysis
Authors: Majhi Somnath
Published: July 2022

National policy on education, various education committees and reports reiterated to implementation of free and compulsory elementary education. Right to Education Act (2009) has made education free and compulsory of children aged 6-14 to ensure Universalization of Elementary Education (UEE). But a country like India which is a mosaic of different castes, creeds and religions always remains a gap in the policy and the implementation at the grassroots level. Drop out remains a major impediment to achieving UEE Goal. West Bengal has a large portion of the Scheduled Caste population. Historically this community is deprived in terms of socio-economic development. The curse like drop out, also seen higher among these communities. In West Bengal, there has been a spatial variation of dropout of Scheduled Caste students. As the poor socio-economic condition is the major reason for the high dropout rate, the Government of West Bengal has taken various initiatives like Kanyashree, Sikhashrre to minimize the dropout rate but still, it has not been possible to achieve the zero drop out goal at school education.
Understanding the Psycho-Social and Health Problems Faced by Homeless Population in Visakhapatnam City: An Empirical Study
Authors: Emely Mopeli Ntsebo , Abraham Mutluri
Published: July 2022

Homelessness is one of the major problems in India and other developing countries. There are 1.8 million homeless people living in India. Most of the time the homeless population live and sleeps on the streets, in parks, at railway stations, bus stations, places of worship, outside businesses and workplaces, at construction sites, under bridges, in Hume pipes, and in other areas that are unsuited for human habitation. The government of India is implementing many welfare schemes to remove the problem of homelessness. This study was conducted in Visakhapatnam city. This is a quantitative study that adopted a descriptive research design. The data was collected from 30 homeless people living on the streets. The study found that the homeless people living on the streets are facing many psycho-social, protection and health problems. Due to poverty, the homeless people do not give more importance to their health and safety. They have bad habits like consuming alcohol (43.3%), smoking (40%), drugs (20%) and Ganja (6.6%). They are not in a position to access the government schemes due to a lack of identity cards. It is high time issues of the homeless are addressed as serious as any other vulnerable groups. The government and NGOs should initiate the new welfare schemes to rescue and restore them to their families. Homeless people should learn vocational education and new livelihood skills to continue their life with dignity.
宗教是什麼？為研究韋伯宗教社會學的準備工作
Authors: 裴元領 裴元領
Published: July 2022

為了理解韋伯的宗教社會學，我們必須先理解「宗教」是什麼。但韋伯從未明示宗教「是」什麼。本文原為研究韋伯宗教社會學的準備工作。以下是關於「宗教是什麼」的猜想。

 瞭解何謂宗教的困難，正出於把宗教當作一個物、對象、概念、因素、變項、範疇、體系、一套儀式或神話奇觀。這些說法可能不無道理，但不知有誰會把這些「道理」套用到自己身上？若自己的人生不能這樣理解，則為何可以這樣理解宗教？這種素樸卻不言而喻的設定顯然是理解的根本障礙。若宗教恆為彼而我恆為此，則再多說法也只在笛卡爾式迷宮裡打轉。

 韋伯主張：一種帶有倫理色彩的生活導引的格律[準則]之特徵，這才是此處所採取的資本主義精神概念的特殊意義。資本主義的概念不是孤立個體，而是人類團體所承擔起來的一種直觀模式。人類團體的直觀模式只是某些人的直觀。這裡沒有神的「靈」，只有世俗人群的「意」。

 宗教不是一成不變的玩偶。在字源上，宗教一詞源於拉丁語的(religare)，意指[再]綑綁約束。宗教被界定為對一個原則的信仰、敬拜、忠誠、或奉獻的一個體系。能重新把信徒綁在一起的思想、信仰和力量體系都是宗教。但「我們」重新綁在一起「練過」什麼？本文保留開放態度。

 

To understand Weber’s sociology of religion, we must first understand what religion is; this is something that Weber never explains. This article is a preparatory work for studying Weber’s sociology of religion. The following is a conjecture on what religion is.

 It is difficult to understand what religion is because it is often regarded as, for example, an object, a concept, a set of rituals, or a set of mythological wonders. These definitions might be somewhat reasonable, but religious adherents typically chafe at their self-application, finding them to be inaccurate or misleading.

 If a person cannot understand their life based on such definitions, how can they be expected to understand religion in this way? This simple but self-evident truth is the main obstacle to understanding religion. If what religion is defined as does not accord with my perception of what religion is to me, this tension is alienating.

 Weber argues that the character of an ethically colored maxim for the conduct of life is linked to the concept of the “spirit of capitalism,” which is applied herein. The concept of capitalism is not based on an isolated individual; rather, it is a mode of intuition perceived by human groups. There is no “spirit” of God here, only the “intention” of secular society.

 Religion is not static. The word religion is derived from the Latin religare, meaning rebinding constraints. Religion is defined as a system of faith, worship, loyalty, or devotion to one principle. The thoughts, beliefs, and power systems that bind believers together are all constitutive elements of religion. The following question must be asked: what is the purpose of this rebinding? The author approaches the topic open to novel realizations.

 
Teaching Thornton Wilder’s Plays
Authors: Bryer Jackson R.
Published: July 2022

This article offers, as one approach to teaching Thornton Wilder’s plays, looking at Wilder’s remarks on the craft of playwriting. These essays, which are not as well-known as his creative works, can also serve to demonstrate for students the qualities which distinguish drama from fiction and poetry. The article also attempts to establish that Wilder is a far more complex and ambivalent playwright than the purveyor of a Norman Rockwell-like pollyannaish vision for which he is often criticized.
Intervención Educativa: Riesgo de Contagio por VIH en Estudiantes Universitarios
Authors: Pacheco Quintana Carmen Cecilia , Miniet Castillo Adriana , González Pardo Secundino
Published: July 2022

El reconocimiento del riesgo, de contraer VIH, como la probabilidad de padecer o contraer esta enfermedad, conduce a transformar positivamente el estado de salud. Se realizó un estudio observacional, cuanti - cualitativo y de intervención educativa, por muestreo aleatorio estratificado, 146 estudiantes de la Universidad Técnica del Norte, con voluntad de participar y permanencia en la institución durante el tiempo de investigación. 

Los estudiantes estuvieron comprendidos entre las edades de 17 – 23 años, el 55 % de las mujeres entre 18 – 20 años, igualmente los hombres, aunque en menos frecuencia de participantes, 28 %, el 70.8 %, refirió información sobre la enfermedad, lo que se modificó positivamente en el 100.0 % de este grupo. El 41 % identificaron las relaciones sexuales desprotegidas como principal riesgo, e igual porcentaje, obtuvo información sobre el tema desde su acceso a Internet. Se concluyó, con variaciones significativas en el conocimiento de universitarios sobre el tema.
Actitudes y prácticas en el cuidado domiciliario de pacientes con Sars Cov 2 en Sucumbios y Orellana
Authors: Tito Pineda Amparo Paola , Tapia Paguay María Ximena , López Aguilar Eva Consuelo
Published: July 2022

El nuevo coronavirus SARS-CoV-2, afecta a más de 5 millones de personas y representa una gran carga para los sistemas de salud en todo el mundo (1), más de 2,5 millones de fallecidos y 117 millones personas infectadas en todo el mundo (2).Estudio realizado con el objetivo de identificar actitudes y prácticas de la población diagnosticada con Sars Cov2, diseño cuantitativo, no experimental de tipo observacional y descriptivo, muestreo no probabilístico por conveniencia, la población  total 355 personas. Los resultados obtenidos: edad media 30 años, género femenino, etnia mestiza, solteros y en unión libre, ubicados en zona urbana, nivel secundario, ocupación, empleados públicos, agricultores, estudiantes y amas de casa; familias conformadas entre 5 y 7 miembros, 1 a 2 habitaciones utilizadas como dormitorio. La actitud de pacientes y cuidadores fue de vulnerabilidad, al estar expuestos a esta enfermedad, exteriorizaron cambios en su estado de ánimo, que incrementó el nivel de estrés al saber que la enfermedad podría complicarse. Las prácticas durante el aislamiento domiciliario demostraron que la población está pendiente de signos y síntomas por posibles complicaciones, usaron mascarilla quirúrgica y al toser o estornudar cubren nariz y boca, pocas personas cambian la mascarilla cuando esta se moja o mancha, además de existir una manipulación de la misma sin el debido cuidado, tampoco lavado de manos y desinfección con alcohol; sumada la mala eliminación de desechos. La medicina ancestral fue utilizada para contrarrestar síntomas leves como fiebre y tos, siendo eucalipto y verbena más utilizados a manera de infusión.
Blood supply and transfusion safety during the COVID-19 pandemic
Authors: Lemssahli Ilham , Belmekki Abdelkader
Published: July 2022

Introduction: The COVID-19 pandemic has put a strain on transfusion practices and safety. The Scientific Committees consider that the COVID-19 pandemic presents a potential risk of reducing and compromising the blood product supply and expressed considerable concern about transfusion safety.

Method: In this concise review, we provide an overview of the implications of COVID-19 for blood safety and sufficiency during the initial phases of the pandemic. We searched the PubMed database, the websites of the World Health Organization, the European Centre for Disease Prevention and Control, the US Communicable Diseases Center. We used the keywords COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the impact of COVID-19 on the blood supply, impact of COVID-19 on blood collection, COVID-19 and transfusion safety, the transmission of SARS-CoV-2 through blood transfusion, COVID-19 symptoms, asymptomatic blood donor, COVID-19 patients.

Results: Data provided from blood transfusion centers and blood banks worldwide show that the COVID-19 pandemic has affected the activities of the blood supply system. It has impacted blood collections and caused a significant decrease in blood donors. The estimated asymptomatic infection rate was 15–46% of SARS-CoV-2 infections. The estimated incubation ranges are between 2 and 11 days, and almost all infections developed symptoms by day 14. The RNAemia phase of SARS-CoV-2 appears to be brief and low level, is typically associated with more severe disease, and is not demonstrated to be an infectious virus. It is detectable in only a tiny proportion of patients. Post-donation, post-transfusion information, and molecular testing of swab samples collected from asymptomatic donors at risk for COVID-19 provided data supporting the absence of transfusion transmission (TT) of COVID-19. The TT risk is currently theoretical. To prevent and minimize respiratory transmission of SARS-CoV-2 to donors and staff while donating blood, blood centers have had to activate their emergency plans and propose appropriate response measures.

Conclusion: The COVID-19 pandemic has a significant impact on blood transfusion activities worldwide. The risk of transmission of COVID-19 through transfusion of blood collected from asymptomatic individuals is now only theoretical and likely minimal. Blood systems should adopt a national approach for coherence and coordination to ensure public confidence in blood safety and supply.
تحديات التعليم عن بعد أثناء جائحة كورونا من وجهة نظر طلبة كلية الآداب والعلوم الإنسانية بجامعة الشرقية
Authors: الحجري راشد , الفارسي عبدالله
Published: July 2022

هدفت هذه الدراسة إلى الكشف عن تحديات التعليم عن بعد في جامعة الشرقية أثناء جائحة كورونا من وجهة نظر طلبة كلية الآداب والعلوم الإنسانية، ولجمع البيانات قام الباحثان بتطوير استبانة وتم التأكد من صدقها وثباتها، وتكونت في صورتها النهائية من (29) فقرة ثم وزعت على جميع طلبة الكلية، وبلغت العينة 299 طالبا وطالبة. أظهرت نتائج الدراسة أن المتوسطات الحسابية جاءت بمستوى متوسط لاستجابات الطلبة لتحديات التعليم عن بعد في أغلب فقرات الاستبانة، ومن أبرز التحديات التي واجهت الطلبة ضعف شبكة الانترنت، وانقطاع التيار الكهربائي، وكثرة الأنشطة والمشاريع التي يكلفون بها، وكذلك عدم توافر البيئة المناسبة للتعلم لدى بعضهم. كما أظهرت نتائج الدراسة عدم وجود فروق ذات دلة إحصائية عند مستوى الدلالة (a ≤ 0.05) بين متوسط تقديرات الطلبة لتحديات التعليم عن بعد تعزى لمتغيرات السنة الدراسية، والجهاز المستخدم (هاتف، حاسوب، تابلت)، ومكان السكن (قرية، مدينة)، ومصدر الانترنت ( واي فاي، هاتف نقال). أما بالنسبة لمتغير نوعية التعليم المفضلة لدى الطلبة بعد انتهاء جائحة كورونا فقد تبين وجود فروق ذات دلالة إحصائية عند مستوى الدلالة (a ≤ 0.05) بين متوسط تقديرات الطلبة لتحديات التعليم عن بعد ولصالح الطلبة الذين يفضلون التعليم المباشر في القاعات الدراسية. وفي ضوء النتائج خلصت الدراسة إلى العديد من التوصيات أبرزها تطوير وتعزيز شبكة الانترنت في السلطنة، وتقليل الأنشطة التي يكلف بها الطلبة قدر الإمكان، والبحث في مشكلة انقطاع التيار الكهربائي مع الجهات المختصة في السلطنة.