bluuebunny/crossref_metadata_2025 huggingface dataset:
A Long-Distance Communication Architecture for Medical Devices Based on LoRaWAN Protocol
Authors: Gaitan Nicoleta Cristina
Published: April 2021

Recent market studies show that the market for remote monitoring devices of different medical parameters will grow exponentially. Globally, more than 4 million individuals will be monitored remotely from the perspective of different health parameters by 2023. Of particular importance is the way of remote transmission of the information acquired from the medical sensors. At this time, there are several methods such as Bluetooth, WI-FI, or other wireless communication interfaces. Recently, the communication based on LoRa (Long Range) technology has had an explosive development that allows the transmission of information over long distances with low energy consumption. The implementation of the IoT (Internet of Things) applications using LoRa devices based on open Long Range Wide-Area Network (LoRaWAN) protocol for long distances with low energy consumption can also be used in the medical field. Therefore, in this paper, we proposed and developed a long-distance communication architecture for medical devices based on the LoRaWAN protocol that allows data communications over a distance of more than 10 km.
Assessing the Conversion of Various Nylon Polymers in the Hydrothermal Liquefaction of Macroalgae
Authors: Hongthong Sukanya , Leese Hannah S. , Allen Michael J. , Chuck Christopher J.
Published: April 2021

Marine macroalgae offers a promising third generation feedstock for the production of fuels and chemicals, avoiding competition with conventional agriculture and potentially helping to improve eutrophication in seas and oceans. However, an increasing amount of plastic is distributed into the oceans, and as such contaminating macroalgal beds. One of the major plastic contaminants is nylon 6 derived from discarded fishing gear, though an increasing amount of alternative nylon polymers, derived from fabrics, are also observed. This study aimed to assess the effect of these nylon contaminants on the hydrothermal liquefaction of Fucus serratus. The hydrothermal liquefaction (HTL) of macroalgae was undertaken at 350 °C for 10 min, with a range of nylon polymers (nylon 6, nylon 6/6, nylon 12 and nylon 6/12), in the blend of 5, 20 and 50 wt.% nylon to biomass; 17 wt.% biocrude was achieved from a 50% blend of nylon 6 with F. serratus. In addition, nylon 6 completely broke down in the system producing the monomer caprolactam. The suitability of converting fishing gear was further demonstrated by conversion of actual fishing line (nylon 6) with the macroalgae, producing an array of products. The alternative nylon polymer blends were less reactive, with only 54% of the nylon 6/6 breaking down under the HTL conditions, forming cyclopentanone which distributed into the biocrude phase. Nylon 6/12 and nylon 12 were even less reactive, and only traces of the monomer cyclododecanone were observed in the biocrude phase. This study demonstrates that while nylon 6 derived from fishing gear can be effectively integrated into a macroalgal biorefinery, alternative nylon polymers from other sectors are too stable to be converted under these conditions and present a real challenge to a macroalgal biorefinery.
Composition and Specialization of the Lichen Functional Traits in a Primeval Forest—Does Ecosystem Organization Level Matter?
Authors: Łubek Anna , Kukwa Martin , Jaroszewicz Bogdan , Czortek Patryk
Published: April 2021

Current trends emphasize the importance of the examination of the functional composition of lichens, which may provide information on the species realized niche diversity and community assembly processes, thus enabling one to understand the specific adaptations of lichens and their interaction with the environment. We analyzed the distribution and specialization of diverse morphological, anatomical and chemical (lichen secondary metabolites) traits in lichen communities in a close-to-natural forest of lowland Europe. We considered these traits in relation to three levels of forest ecosystem organization: forest communities, phorophyte species and substrates, in order to recognize the specialization of functional traits to different levels of the forest complexity. Traits related to the sexual reproduction of mycobionts (i.e., ascomata types: lecanoroid apothecia, lecideoid apothecia, arthonioid apothecia, lirellate apothecia, stalked apothecia and perithecia) and asexual reproduction of mycobionts (pycnidia, hyphophores and sporodochia) demonstrated the highest specialization to type of substrate, tree species and forest community. Thallus type (foliose, fruticose, crustose and leprose thalli), ascospore dark pigmentation and asexual reproduction by lichenized diaspores (soredia and isidia) revealed the lowest specialization to tree species and substrate, as well as to forest community. Results indicate that lichen functional trait assemblage distribution should not only be considered at the level of differences in the internal structure of the analyzed forest communities (e.g., higher number of diverse substrates or tree species) but also studied in relation to specific habitat conditions (insolation, moisture, temperature, eutrophication) that are characteristic of a particular forest community. Our work contributes to the understanding of the role of the forest structure in shaping lichen functional trait composition, as well as enhancing our knowledge on community assembly rules of lichen species.
Spices in the Apiaceae Family Represent the Healthiest Fatty Acid Profile: A Systematic Comparison of 34 Widely Used Spices and Herbs
Authors: Saini Ramesh Kumar , Assefa Awraris Derbie , Keum Young-Soo
Published: April 2021

Spices and herbs are well-known for being rich in healthy bioactive metabolites. In recent years, interest in the fatty acid composition of different foods has greatly increased. Thus, the present study was designed to characterize the fatty acid composition of 34 widely used spices and herbs. Utilizing gas chromatography (GC) flame ionization detection (FID) and GC mass spectrometry (MS), we identified and quantified 18 fatty acids. This showed a significant variation among the studied spices and herbs. In general, oleic and linoleic acid dominate in seed spices, whereas palmitic, stearic, oleic, linoleic, and α-linolenic acids are the major constituents of herbs. Among the studied spices and herbs, the ratio of n−6/n−3 polyunsaturated fatty acids (PUFAs) was recorded to be in the range of 0.36 (oregano) to 85.99 (cumin), whereas the ratio of PUFAs/saturated fatty acids (SFAs) ranged from 0.17 (nutmeg) to 4.90 (cumin). Cumin, coriander, fennel, and dill seeds represent the healthiest fatty acid profile, based upon fat quality indices such as the ratio of hypocholesterolemic/hypercholesterolemic (h/H) fatty acids, the atherogenic index (AI), and the thrombogenic index (TI). All these seed spices belong to the Apiaceae family of plants, which are an exceptionally rich source of monounsaturated fatty acids (MUFAs) in the form of petroselinic acid (C18:1n12), with a very small amount of SFAs.
Antifreeze Protein Improves the Cryopreservation Efficiency of Hosta capitata by Regulating the Genes Involved in the Low-Temperature Tolerance Mechanism
Authors: Pe Phyo Phyo Win , Naing Aung Htay , Kim Chang Kil , Park Kyeung Il
Published: April 2021

In this study, whether the addition of antifreeze protein (AFP) to a cryopreservative solution (plant vitrification solution 2 (PVS2)) is more effective in reducing freezing injuries in Hosta capitata than PVS2 alone at different cold exposure times (6, 24, and 48 h) is investigated. The upregulation of C-repeat binding factor 1 (CBF1) and dehydrin 1 (DHN1) in response to low temperature was observed in shoots. Shoots treated with distilled water (dH2O) strongly triggered gene expression 6 h after cold exposure, which was higher than those expressed in PVS2 and PVS2+AFP. However, 24 h after cold exposure, gene expressions detected in dH2O and PVS2 treatments were similar and higher than PVS2 + AFP. The expression was highest in PVS2+AFP when the exposure time was extended to 48 h. Similarly, nitric reductase activities 1 and 2 (Nia1 and Nia2) genes, which are responsible for nitric oxide production, were also upregulated in low-temperature-treated shoots, as observed for CBF1 and DHN1 expression patterns during cold exposure periods. Based on the gene expression patterns, shoots treated with PVS2+AFP were more likely to resist cold stress, which was also associated with the higher cryopreservation efficiency of PVS2+AFP compared to PVS2 alone. This finding suggests that the improvement of cryopreservation efficiency by AFP could be due to the transcriptional regulation of CBF1, DHN1, Nia1, and Nia2, which might reduce freezing injuries during cryopreservation. Thus, AFP could be potentially used as a cryoprotectant in the cryopreservation of rare and commercially important plant germplasm.
A COVID-19 Rehabilitation Prospective Surveillance Model for Use by Physiotherapists
Authors: Postigo-Martin Paula , Cantarero-Villanueva Irene , Lista-Paz Ana , Castro-Martín Eduardo , Arroyo-Morales Manuel , Seco-Calvo Jesús
Published: April 2021

The long-term sequelae of coronavirus disease 2019 (COVID-19) are only now beginning to be defined, but it is already known that the disease can have direct and indirect impacts mainly on the cardiorespiratory and neuromuscular systems and may affect mental health. A role for rehabilitation professionals from all disciplines in addressing COVID-19 sequelae is recognised, but it is essential that patient assessment be systematic if health complications are to be identified and treated and, if possible, prevented. The aim is to present a COVID-19 prospective surveillance model based on sensitive and easily used assessment tools, which is urgently required. Following the Oxford Centre for Evidence-Based Medicine Level of Evidence Tool, an expert team in cardiorespiratory, neuromuscular and mental health worked via telemeetings to establish a model that provides guidelines to rehabilitation professionals working with patients who require rehabilitation after suffering from COVID-19. A COVID-19 prospective surveillance model is proposed for use by rehabilitation professionals and includes both face-to-face and telematic monitoring components. This model should facilitate the early identification and management of long-term COVID-19 sequelae, thus responding to an arising need.
Assessment of Liver Fibrosis Stage Using Integrative Analysis of Hepatic Heterogeneity and Nodularity in Routine MRI with FIB-4 Index as Reference Standard
Authors: Kim Tae-Hoon , Jeong Chang-Won , Kim Ji , Kim Jin , Jo Hoon , Kim Youe , Lee Young , Yoon Kwon-Ha
Published: April 2021

Image-based quantitative methods for liver heterogeneity (LHet) and nodularity (LNod) provide helpful information for evaluating liver fibrosis; however, their combinations are not fully understood in liver diseases. We developed an integrated software for assessing LHet and LNod and compared LHet and LNod according to fibrosis stages in chronic liver disease (CLD). Overall, 111 CLD patients and 16 subjects with suspected liver disease who underwent liver biopsy were enrolled. The procedures for quantifying LHet and LNod were bias correction, contour detection, liver segmentation, and LHet and LNod measurements. LHet and LNod scores among fibrosis stages (F0–F3) were compared using ANOVA with Tukey’s test. Diagnostic accuracy was determined by calculating the area under the receiver operating characteristics (AUROC) curve. The mean LHet scores of F0, F1, F2, and F3 were 3.49 ± 0.34, 5.52 ± 0.88, 6.80 ± 0.97, and 7.56 ± 1.79, respectively (p < 0.001). The mean LNod scores of F0, F1, F2, and F3 were 0.84 ± 0.06, 0.91 ± 0.04, 1.09 ± 0.08, and 1.15 ± 0.14, respectively (p < 0.001). The combined LHet × LNod scores of F0, F1, F2, and F3 were 2.96 ± 0.46, 5.01 ± 0.91, 7.30 ± 0.89, and 8.48 ± 1.34, respectively (p < 0.001). The AUROCs of LHet, LNod, and LHet × LNod for differentiating F1 vs. F2 and F2 vs. F3 were 0.845, 0.958, and 0.954; and 0.619, 0.689, and 0.761, respectively. The combination of LHet and LNod scores derived from routine MR images allows better differential diagnosis of fibrosis subgroups in CLD.
Radial Extracorporeal Shockwave Therapy versus Ultrasound Therapy in Adult Patients with Idiopathic Scoliosis
Authors: Daia Cristina , Scheau Cristian , Toader Corneliu , Bumbea Ana Maria , Caimac Visarion Danut , Andone Ioana , Popescu Cristina , Spanu Aura , Onose Gelu
Published: April 2021

Background: This study aimed to compare the effectiveness of radial extracorporeal shockwave and ultrasound therapies in adult patients with idiopathic scoliosis in terms of pain, disability, and quality of life. Methods: Forty-eight patients with idiopathic scoliosis were randomly divided into three groups of 16: shockwave, ultrasound, and control. The patients were evaluated at admission (day one) and at discharge (day 14) for pain, by using the visual analogue scale; for disability, by using the Oswestry disability index; and for the quality of life, with short form-36. Results: Radial extracorporeal shockwave therapy was more effective than ultrasound in reducing pain (p = 0.004) and increasing quality of life, bringing extra vitality (p = 0.003) and emotional comfort (p = 0.007) to the patient. Both shockwave therapy (p = 0.001) and ultrasound therapy (p = 0.003) were effective in reducing pain. In terms of disability, both treatments had similar effects (p = 0.439). Conclusion: Radial shockwave was significantly more effective than ultrasound in reducing pain and increasing the quality of life, bringing additional vitality and emotional comfort to the patient with idiopathic scoliosis. In terms of disability, both treatments had similar effects when associated with kinesitherapy.
Long-Term Follow-Up of Inpatients with Failed Back Surgery Syndrome Who Received Integrative Korean Medicine Treatment: A Retrospective Analysis and Questionnaire Survey Study
Authors: Park Ju-Hun , Choi Kang-Eah , Kim Sang-Gyun , Chu Hui-Yeong , Lee Sang-Woon , Kim Tae-Ju , Cho Hyun-Woo , Kim Sang Don , Park Kyoung Sun , Lee Yoon Jae , Lee Jin Ho , Ha In-Hyuk
Published: April 2021

Introduction: this study aimed to investigate the long-term clinical efficacy and satisfaction degree of integrative Korean medicine (KM) treatment for patients with failed back surgery syndrome (FBSS). Methods: we performed a follow-up questionnaire survey and retrospective analysis of medical records for patients with FBSS who underwent inpatient treatment for ≥ 1 week. The primary evaluation indices were numeric rating scale (NRS) scores for low back pain (LBP) and leg pain at admission and discharge. Sub-evaluation indices included the Oswestry Disability Index (ODI) and EuroQol 5-dimension (EQ-5D) score. The follow-up questionnaire survey obtained information regarding previous surgeries; reasons for satisfaction/dissatisfaction with surgical and KM treatment; and current status. Results: compared with at admission, there was a significant post-treatment decrease in the NRS scores for LBP and leg pain, as well as the ODI score. Further, there was a significant post-treatment increase in the EQ-5D score. Regarding the patients’ global impression of change for KM treatment administered during admission and at the follow-up questionnaire survey, 101 (95.3%) patients selected “minimally improved” or better. Conclusion: integrative KM treatment could effectively reduce pain, as well as improve function and health-related quality of life, in patients with FBSS.
The Prognostic Role of Early Skeletal Muscle Mass Depletion in Multimodality Management of Patients with Advanced Gastric Cancer Treated with First Line Chemotherapy: A Pilot Experience from Modena Cancer Center
Authors: Rimini Margherita , Pecchi Annarita , Prampolini Francesco , Bussei Chiara , Salati Massimiliano , Forni Daniela , Martelli Francesca , Valoriani Filippo , Canino Fabio , Bocconi Alessandro , Gelsomino Fabio , Reverberi Linda , Benatti Stefania , Piacentini Federico , Menozzi Renata , Dominici Massimo , Luppi Gabriele , Spallanzani Andrea
Published: April 2021

Background: Few data about the link between nutritional status and survival are available in the metastatic gastric cancer (GC) setting. The aim of this work was to evaluate the prognostic role of tissue modifications during treatment and the benefit of a scheduled nutritional assessment in this setting. Methods: Clinical and laboratory variables of 40 metastatic GC patients treated at Modena Cancer Center were retrieved: 20 received a nutritional assessment on the oncology’s discretion, the other 20 received a scheduled nutritional assessment at baseline and every 2–4 weeks. Anthropometric parameters were calculated on Computed Tomography (CT) images at the baseline and after 3 months of chemotherapy. Results: A correlation between baseline Eastern Cooperative Oncology Group Performance Status (ECOG PS), Lymphocyte to Monocyte Ratio (LMR), C-reactive protein (PCR), Prognostic Nutritional Index (PNI) and Overall survival (OS) was highlighted. Among the anthropometric parameters, early skeletal muscle mass depletion (ESMMD) >10% in the first months of treatment significantly impacted on mOS (p = 0.0023). A link between ESMMD and baseline LDH > 460 U/L, baseline CRP > 2.2 mg/dL and weight decrease during treatment emerged. Patients evaluated with a nutritional scheduled support experienced a mean gain in subcutaneous and visceral fat of 11.4% and 10.21%, respectively. Conclusion: We confirm the prognostic impact of ESMMD > 10% during chemotherapy in metastatic GC. The prognostic role of a scheduled nutritional assessment deserves further confirmation in large prospective trials.
Influence of Heat Treatments, Parameters and Machining Conditions on Machinability in the Turning of Recycled 6061 Aluminum Alloy
Authors: Mandatsy Moungomo Jean Brice , Kibouka Guy Richard , Nganga-Kouya Donatien
Published: April 2021

Some manufacturing companies now use recycled aluminum alloys. It is important that they have the necessary data relating to the control of the machinability of these alloys. Thus, this study on the machinability in the turning of two recycled aluminum alloys by a 6061 R and 6061 R-T6 smelter was conducted. The aim of this study is to provide solutions to the problem posed, which is whether recycled aluminum alloys have good machinability skills, such as virgin aluminum alloys. To provide these solutions, the experimental designs were used to study the influence of cutting parameters and conditions (feed, cutting speed, lubrication) and material hardness on machinability characteristics (surface roughness, mass concentration of metal particles, and chip morphology). The results of this study show that the two alloys studied have good machinability. The feed, hardness and lubrication significantly influence the machinability of these two alloys. Predictive models to assess the machinability of these recycled alloys have been established.
Multiple Submerged Tidal Notches: A Witness of Sequences of Coseismic Subsidence in the Aegean Sea, Greece
Authors: Karkani Anna , Evelpidou Niki
Published: April 2021

In some islands of the Aegean, there is evidence of the occurrence of repeated rapid subsidences during the Late Holocene. In this paper, the shape of tidal notches that may be well-preserved underwater is recalled in order to reconstruct sequences of coseismic subsidences and other relative sea-level changes, which occurred during, at least, the last few millennia. A reanalysis of the published measurements of submerged tidal notches in several islands reveals that subsidence trends in many areas of the Aegean are not continuous with gradual movement but, also, are the result of repeated coseismic vertical subsidences of some decimetres at each time. The estimated average return times are of the order of approximately some centuries to one millennium. Although the results cannot be used for short-term predictions of earthquakes, they may provide useful indications on the long-term tectonic trends that are active in the Aegean region.
Improved Tolerance of Mycorrhizal Torreya grandis Seedlings to Sulfuric Acid Rain Related to Phosphorus and Zinc Contents in Shoots
Authors: Xia Lina , Shao Changliang , Zhang Naili , Wu Aiping , Xie Jiangbo , Qiu Yajing , He Xiaobin , Pei Jia , Wang Xudong , Wang Yanhong
Published: April 2021

Acid rain (AR) is an increasingly serious environmental problem that frequently occurs in Southern China with sulfuric acid rain (SAR) as the main type. SAR can negatively affect the growth and physiological properties of trees, but mycorrhizal associations may mitigate such detrimental effects. However, the mechanisms by which arbuscular mycorrhizal fungi control SAR-induced impacts on Torreya grandis plants remain unclear. A pot experiment was conducted on T. grandis seedlings, an economically important tree species in Southern China, in which inoculated and non-inoculated T. grandis seedlings were subjected to three simulated SAR regimes (pH of 5.6, 4.0, and 2.5, respectively) to examine the effects on the growth, osmotic regulation, and nutrient absorption of these seedlings. The results show that, although SAR had no effect on the accumulation of biomass, it significantly decreased the concentrations of proline and soluble protein, shoot Zn2+, P, K+, and Ca2+ concentrations, and the Fe2+ and Mn2+ concentrations of shoots and roots. Mycorrhizal inoculation, especially with Rhizophagus irregularis, significantly increased total biomass, proline concentration, and the Zn2+, P, and K+ concentrations in the shoots of T. grandis under lower pH conditions. Moreover, our findings suggest that the combination of root colonization, acid tolerance, and the concentrations of shoot-P, shoot-Zn2+, and root-Fe2+ of T. grandis jointly conferred mycorrhizal benefits on the plants under SAR conditions. Given the enhancement of the nutritional quality of T. grandis owing to mycorrhizal associations, inoculation with R. irregularis may be preferable for the culturing and management of these plants under acidic conditions.
Following Rural Functions to Classify Rural Sites: An Application in Jixi, Anhui Province, China
Authors: Ren Kai
Published: April 2021

Rural areas are a type of self-organized regional living environment, with multi-functional symbiosis between humans and land; their functional attributes are function superposition, function difference, and dominant function. The evolution of rural functions is a gradual process and follows the general law of the development of self-organizing systems, which evolutes from the state of general development, competition without rules, and, finally, to an order controlled by the dominant function. By constructing an indicator system and measurement model of rural function evaluation, this study took 11 towns in a hilly area of Jixi County as regional units to analyze the differentiation characteristics and rules of rural functions; the functions include agricultural production functions, nonagricultural production functions, life and leisure functions, and ecological functions. The results show the following: (1) The index of agricultural production functions, life and leisure functions, and ecological functions in Jixi County is higher, while the index of nonagricultural production functions is lower; (2) all towns have at least one function belongings to the “high state strong potential zone”, and some towns show a weak comprehensiveness; (3) the interaction between different functions should be considered when determining the dominant functions of the towns; (4) the formation mechanism of a dominant function has a high correlation with its main influencing factors; and (5) nine types of characteristic village are determined, according to the coupling of village characteristic resources and town dominant functions.
Developing an Ecosystem Services-Based Approach for Land Use Planning
Authors: Cai Wenbo , Jiang Wei , Cai Yongli
Published: April 2021

Rapid urbanization has altered many ecosystems, causing the decline in many ecosystem services (ES), and generating serious ecological crisis. The Yangtze River Delta (YRD) region is one of the most rapidly urbanized regions in China and has experienced a remarkable period of population growth, and built-up area expansion. To cope with these challenges, this paper proposed a four-step key ES zone delineation framework by land-use matrix for land management in a rapidly urbanizing region. This framework was applied in key ES zone delineation in the YRD region. The results showed that there was obvious spatial heterogeneity in the distribution of total ES capacities: The high-capacity levels were mainly distributed in the south of the region, while the low-capacity levels were densely distributed in the middle and north of the region. V (80–100) and II (20–40) accounted for 27.44% and 47.12% of the total area, respectively. Among the five levels, Level II occupied the largest area of the region. I (0–20) and IV (60–80) had patchy patterns in the region and clustered in the middle of the region. I and IV accounted for 13.24% and 5.48% of the total area, respectively. III (40–60) had belt distribution in the region and accounted for 6.72% of the total area. This paper not only contributes to the guidance of land management for the Ecological Redline Policy in the YRD Region but also helps to improve the application of ecosystem service approach in decision support in rapidly urbanizing regions.
Tribological Evaluation of Turbostratic 2D Graphite as Oil Additive
Authors: Dias Halley Welther Jacques , Medeiros Alessandra Batista , Binder Cristiano , Rodrigue Neto João Batista , Klein Aloísio Nelmo , de Mello José Daniel Biasoli
Published: April 2021

In this study, powder technology was used to obtain Fe-SiC composites in which SiC particles act as precursors to generate a large amount of turbostratic graphite dispersed in the composite matrix. The selection of the alloy composition was studied employing Thermo-Calc® software to obtain the temperature and composition range for the stabilization of the graphite phase in iron with a high yield. The extracted turbostratic 2D graphite particles were dispersed in mineral oil in order to evaluate the potential of these particles as a lubricating oil additive. The structure and morphology of the extracted graphite were examined by Raman spectroscopy and transmission electron microscopy (TEM), indicating the highly disordered nature of turbostratic graphite. Reductions in the friction coefficient and wear rate of a tribological pair were observed when compared to the pure mineral oil and mineral oil with commercial graphite particles added. The misorientation and increase in interplanar distances of turbostratic 2D graphite induce a low degree of interaction between these atomic planes, which contributes to the low-friction coefficient and the lower wear rate obtained for this system.
Multi-Task Optimization and Multi-Task Evolutionary Computation in the Past Five Years: A Brief Review
Authors: Xu Qingzheng , Wang Na , Wang Lei , Li Wei , Sun Qian
Published: April 2021

Traditional evolution algorithms tend to start the search from scratch. However, real-world problems seldom exist in isolation and humans effectively manage and execute multiple tasks at the same time. Inspired by this concept, the paradigm of multi-task evolutionary computation (MTEC) has recently emerged as an effective means of facilitating implicit or explicit knowledge transfer across optimization tasks, thereby potentially accelerating convergence and improving the quality of solutions for multi-task optimization problems. An increasing number of works have thus been proposed since 2016. The authors collect the abundant specialized literature related to this novel optimization paradigm that was published in the past five years. The quantity of papers, the nationality of authors, and the important professional publications are analyzed by a statistical method. As a survey on state-of-the-art of research on this topic, this review article covers basic concepts, theoretical foundation, basic implementation approaches of MTEC, related extension issues of MTEC, and typical application fields in science and engineering. In particular, several approaches of chromosome encoding and decoding, intro-population reproduction, inter-population reproduction, and evaluation and selection are reviewed when developing an effective MTEC algorithm. A number of open challenges to date, along with promising directions that can be undertaken to help move it forward in the future, are also discussed according to the current state. The principal purpose is to provide a comprehensive review and examination of MTEC for researchers in this community, as well as promote more practitioners working in the related fields to be involved in this fascinating territory.
Deep Learning for Wave Energy Converter Modeling Using Long Short-Term Memory
Authors: Mousavi Seyed Milad , Ghasemi Majid , Dehghan Manshadi Mahsa , Mosavi Amir
Published: April 2021

Accurate forecasts of ocean waves energy can not only reduce costs for investment, but it is also essential for the management and operation of electrical power. This paper presents an innovative approach based on long short-term memory (LSTM) to predict the power generation of an economical wave energy converter named “Searaser”. The data for analysis is provided by collecting the experimental data from another study and the exerted data from a numerical simulation of Searaser. The simulation is performed with Flow-3D software, which has high capability in analyzing fluid–solid interactions. The lack of relation between wind speed and output power in previous studies needs to be investigated in this field. Therefore, in this study, wind speed and output power are related with an LSTM method. Moreover, it can be inferred that the LSTM network is able to predict power in terms of height more accurately and faster than the numerical solution in a field of predicting. The network output figures show a great agreement, and the root mean square is 0.49 in the mean value related to the accuracy of the LSTM method. Furthermore, the mathematical relation between the generated power and wave height was introduced by curve fitting of the power function to the result of the LSTM method.
Predicting Stock Market Investment Intention and Behavior among Malaysian Working Adults Using Partial Least Squares Structural Equation Modeling
Authors: Yang Marvello , Mamun Abdullah Al , Mohiuddin Muhammad , Al-Shami Sayed Samer Ali , Zainol Noor Raihani
Published: April 2021

The purpose of this study was to investigate the effects of risk tolerance, financial well-being, financial literacy, overconfidence bias, herding behavior, and social interaction on stock market investment intention and stock market participation among working adults in Malaysia. Adopting the cross-sectional design, this study collected quantitative data from a total of 349 respondents in an online survey via Google form link across various social media platforms. This study used the partial least squares structural equation modeling (PLS-SEM) approach to test the hypotheses. This study revealed the significant positive effects of risk tolerance, herding behavior, and social interaction on stock market investment intention. Stock market investment intention also had a significant effect on stock market participation. Stock market investment intention was also found to successfully mediate the relationships of risk tolerance and overconfidence bias with stock market participation. When it comes to stock market investment, the government and related authorities should focus on developing programs and policies that provide a financial safety net for investors and promote investment-related social platforms. This study linked risk tolerance, financial well-being, financial literacy, overconfidence bias, herding behavior, social interaction, stock market investment intention, and stock market participation. This is one of the few early attempts to address issues in light of the stock market investment participation among the working adults in a developing country.
Screening for Gestational Diabetes during the COVID-19 Pandemic—Current Recommendations and Their Consequences
Authors: Panaitescu Anca Maria , Ciobanu Anca Marina , Popa Maria , Duta Irina , Gica Nicolae , Peltecu Gheorghe , Veduta Alina
Published: April 2021

Gestational diabetes mellitus (GDM) is recognized as one of the most common medical complications of pregnancy that can lead to significant short-term and long-term risks for the mother and the fetus if not detected early and treated appropriately. Current evidence suggests that, with the use of appropriate screening programs for GDM, those women diagnosed and treated have reduced perinatal morbidity. It has been implied that, when screening for GDM, there should be uniformity in the testing used and in further management. This paper summarizes and compares current screening strategies proposed by international bodies and discusses application in the context of the COVID-19 pandemic.
Simulation Research of Hydraulic Stepper Drive Technology Based on High Speed On/Off Valves and Miniature Plunger Cylinders
Authors: Qiu Hanyu , Su Qi
Published: April 2021

The technology for stepper drive that can achieve accurate motion in the hydraulic field has always been urgently needed in the industry. This paper proposes a hydraulic stepper drive based on five high speed on/off valves and two miniature plunger cylinders. The stepper drive discretizes the continuous flow medium into fixed small steps through the miniature plunger cylinder and realizes the state control of the drive through the logic action of the high speed on/off valve. This paper improves the current stepper drive and establishes a mathematical model to analyze the error of the drive and calculate the position of the actuator. In addition, through simulation research, the performance parameters such as the single-step step characteristic and pressure characteristic of the stepper drive are studied. The results show that, compared with the technology of current stepper drive, this stepper drive can effectively remove the “post step” phenomenon, greatly improve the stepper accuracy of the stepper drive, and have a more excellent performance.
Required Plug Strength for Continuously Poured Cemented Paste Backfill in Longhole Stopes
Authors: Grabinsky Murray , Bawden Will , Thompson Ben
Published: April 2021

Continuously poured paste backfill dramatically improves underground mining efficiency through reduced stope cycle time and simplified logistics. For longhole stopes, a backfill “plug” is poured to a few meters above the undercut brow and must gain sufficient strength to prevent failure through the plug when the “main” pour begins. A novel, rational engineering design approach that determines the required plug strength is developed. The potential failure mechanism during continuous pouring is identified and the theoretical solution and its numerical validation/calibration are discussed. Four field case histories are then used, three of them involving continuous pours, to demonstrate the theoretical solution’s validity in back-analysis. These case studies are unique in the extent and quality of total stress and water pressure measurements made throughout backfilling. Additionally, comprehensive laboratory data are available to characterize strength development during binder hydration in the first few days, which are critical to the back-analyses. Results indicate that continuous backfilling is feasible with reasonably attainable backfill strengths at most mines. However, mines must undertake comprehensive early strength laboratory testing, and must carry out field measurements during the pour to ensure the placed backfill behaviour is consistent with the analysis assumptions.
Application of the Dehydration Homogeneous Liquid–Liquid Extraction (DHLLE) Sample Preparation Method for Fingerprinting of Honey Volatiles
Authors: Kuś Piotr M. , Jerković Igor
Published: April 2021

Recently, we proposed a new sample preparation method involving reduced solvent and sample usage, based on dehydration homogeneous liquid–liquid extraction (DHLLE) for the screening of volatiles and semi-volatiles from honey. In the present research, the method was applied to a wide range of honeys (21 different representative unifloral samples) to determine its suitability for detecting characteristic honey compounds from different chemical classes. GC-FID/MS disclosed 130 compounds from different structural and chemical groups. The DHLLE method allowed the extraction and identification of a wide range of previously reported specific and nonspecific marker compounds belonging to different chemical groups (including monoterpenes, norisoprenoids, benzene derivatives, or nitrogen compounds). For example, DHLLE allowed the detection of cornflower honey chemical markers: 3-oxo-retro-α-ionols, 3,4-dihydro-3-oxoedulan, phenyllactic acid; coffee honey markers: theobromine and caffeine; linden honey markers: 4-isopropenylcyclohexa-1,3-diene-1-carboxylic acid and 4-(2-hydroxy-2-propanyl)cyclohexa-1,3-diene-1-carboxylic acid, as well as furan derivatives from buckwheat honey. The obtained results were comparable with the previously reported data on markers of various honey varieties. Considering the application of much lower volumes of very common reagents, DHLLE may provide economical and ecological advantages as an alternative sample preparation method for routine purposes.
Anti-Inflammatory Properties In Vitro and Hypoglycaemic Effects of Phenolics from Cultivated Fruit Body of Phellinus baumii in Type 2 Diabetic Mice
Authors: Yang Kai , Zhang Su , Geng Yan , Tian Baoming , Cai Ming , Guan Rongfa , Li Yougui , Ye Bangwei , Sun Peilong
Published: April 2021

Dietary intervention in type 2 diabetes mellitus (T2DM) is a hotspot in international research because of potential threats to human health. Phellinus baumii, a wild fungus traditionally used as a food and medicine source, is now cultivated in certain East Asian countries, and is rich in polyphenols, which are effective anti-inflammatory ingredients useful in treatment of T2DM, with fewer side effects than drugs. To examine the hypoglycaemic effects of Phellinus baumii phenolics (PPE), the metabolite profiles of T2DM mice induced by streptozotocin after PPE intervention were systematically analyzed. Here, 10 normal mice were given normal saline as control group, and 50 model mice were randomly assigned to five groups and daily intragastric administrated with saline, metformin (100 mg/kg), and PPE (50, 100, 150 mg/kg of body weight), for 60 days. The pro-inflammatory factor contents of lipopolysaccharide stimulation of RAW 264.7 cells were decreased in a dose-dependent manner after PPE treatment, we propose that PPE could exert anti-inflammatory properties. PPE could also effectively reduce blood glucose levels, increased insulin sensitivity, and improved other glucolipid metabolism. Q-PCR results suggested that the hypoglycemic effects of PPE might be through activating IRS1/PI3K/AKT pathway in diabetic mice. These results suggest that PPE has strong potential as dietary components in the prevention or management of T2DM.
Biosynthesis and Anti-Mycotoxigenic Activity of Zingiber officinale Roscoe-Derived Metal Nanoparticles
Authors: Raafat Mohamed , El-Sayed Ashraf S. A. , El-Sayed Manal T.
Published: April 2021

Mycotoxigenic fungi have attracted special attention due to their threat to food security and toxicity to human health. Aqueous extract of Zingiber officinale Roscoe was used as reducing and capping agent for the synthesis of silver (AgNPs), copper (CuNPs), and zinc oxide (ZnONPs) nanoparticles. UV-Visible spectra of the AgNPs, CuNPs, and ZnONPs showed absorption peaks at λmax 416 nm, 472 nm, and 372 nm, respectively. Zeta potential of AgNPs, CuNPs, and ZnONPs were −30.9, −30.4 and −18.4 mV, respectively. ZnONPs showed the highest activity against Aspergillus awamori ZUJQ 965830.1 (ZOI 20.9 mm and MIC 24.7 µg/mL). TEM micrographs of ZnONPs-treated A. awamori showed cracks and pits in the cell wall, liquefaction of the cytoplasmic content, making it less electron-dense. The sporulation and ochratoxin A production of A. awamori was inhibited by ZnONPs in a concentration-dependent pattern. The inhibition percentage of OTA were 45.6, 84.78 and 95.65% for 10, 15, 20 of ZnONPs/mL, respectively.
Anticarcinogenic and Antioxidant Action of an Edible Aquatic Flora Jussiaea repens L. Using In Vitro Bioassays and In Vivo Zebrafish Model
Authors: Rajiv Chongtham , Roy Subhra Saikat , Tamreihao K. , Kshetri Pintubala , Singh Thangjam Surchandra , Sanjita Devi Haobijam , Sharma Susheel Kumar , Ansari Meraj Alam , Devi Elangbam Diana , Devi Asem Kajal , Langamba Pangambam , Singh Heikham Naresh , Akoijam Romila , Tania Chongtham , Sonia Chongtham
Published: April 2021

Oxidative stress is the major cause of many health conditions, and regular consumption of antioxidants helped to encounter and prevent such oxidative stress-related diseases. Due to safety concerns over long-term uses of synthetic antioxidants, natural antioxidants are more preferred. The purpose of this study is to investigate the antioxidant and anticancer activities of Jussiaea repens L., a wild edible flora found in Manipur, India. The antioxidant activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), Ferric reducing antioxidant power (FRAP) assay and DNA-nicking assay. The anticancer activity was tested using five cancer lines viz., SKOV3 cells (ovarian), HeLa (cervical), MDA-MB-231 (breast), PANC-1 (pancreatic), and PC3 (prostate). The toxicity, developmental effect, antiproliferative activity was further tested using zebrafish embryos. The methanolic plant extract had higher polyphenol content than flavonoids. The in vitro study demonstrated a promising antioxidant capacity and DNA protection ability of this plant. The extract also showed cytotoxic activity against SKOV3, HeLa, MDA-MB-23, and PANC-1 cancer cell lines. The in vivo studies on zebrafish embryos demonstrated the extract’s ability to suppress the developmental process and elicited more cytotoxicity to cancer cells than developing zebrafish embryos. Moreover, the in vivo studies on zebrafish embryos also indicated the antiproliferative activity of J. repens L. extract.
Artocarpin Targets Focal Adhesion Kinase-Dependent Epithelial to Mesenchymal Transition and Suppresses Migratory-Associated Integrins in Lung Cancer Cells
Authors: Nonpanya Nongyao , Sanookpan Kittipong , Sriratanasak Nicharat , Vinayanuwattikun Chanida , Wichadakul Duangdao , Sritularak Boonchoo , Chanvorachote Pithi
Published: April 2021

Focal adhesion kinase (FAK) controls several cancer aggressive potentials of cell movement and dissemination. As epithelial–mesenchymal transition (EMT) and the migratory-associated integrins, known influencers of metastasis, have been found to be linked with FAK activity, this study unraveled the potential pharmacological effect of artocarpin in targeting FAK resulting in the suppression of EMT and migratory behaviors of lung cancer cells. Treatment with artocarpin was applied at concentrations of 0–10 μM, and the results showed non-cytotoxicity in lung cancer cell lines (A549 and H460), normal lung (BEAS-2B) cells and primary metastatic lung cancer cells (ELC12, ELC16, and ELC20). We also found that artocarpin (0–10 µM) had no effect on cell viability, proliferation, and migration in BEAS-2B cells. For metastasis-related approaches, artocarpin significantly inhibited cell migration, invasion, and filopodia formation. Artocarpin also dramatically suppressed anchorage-independent growth, cancer stem cell (CSC) spheroid formation, and viability of CSC-rich spheroids. For molecular targets of artocarpin action, computational molecular docking revealed that artocarpin had the best binding affinity of −8.0 kcal/mol with FAK protein. Consistently, FAK-downstream proteins, namely active Akt (phosphorylated Akt), active mTOR (phosphorylated mTOR), and Cdc42, and EMT marker and transcription factor (N-cadherin, Vimentin, and Slug), were found to be significantly depleted in response to artocarpin treatment. Furthermore, we found the decrease of Caveolin-1 (Cav-1) accompanied by the reduction of integrin-αν and integrin-β3. Taken together, these findings support the anti-metastasis potentials of the compound to be further developed for cancer therapy.
Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream
Authors: Alves Teresa , Arranca Daniel , Martins Ana , Ribeiro Helena , Raposo Sara , Marto Joana
Published: April 2021

Semisolids constitute a significant proportion of topical pharmaceutical dosage forms available on the market, with creams being considered profitable systems for releasing active substances into the skin. This work aimed at the development of a generic Clotrimazole topical cream, based on the assumptions that assist the development of such formulations. First, the critical parameters to obtain a final formulation as similar as possible to the reference product were defined. Then, the percentages of cetyl palmitate and octyldodecanol were identified as critical variables and chosen for optimization in further studies. A “quality by design” approach was then used to identify the effect of process variability on the structural and functional similarity (Q3) of the generic product qualitatively (Q1) and quantitatively (Q2). A two-factor central composite orthogonal design was applied and eleven different formulations were developed and subjected to physicochemical characterization and product performance studies. The results were used to estimate the influence of the two variables in the variation of the responses, and to determine the optimum point of the tested factors, using a design space approach. Finally, an optimized formulation was obtained and analysed in parallel with the reference. The obtained results agreed with the prediction of the chemometric analysis, validating the reliability of the developed multivariate models. The in vitro release and permeation results were similar for the reference and the generic formulations, supporting the importance of interplaying microstructure properties with product performance and stability. Lastly, based on quality targets and response constraints, optimal working conditions were successfully achieved.
Influence of Macroscopic Wall Structures on the Fluid Flow and Heat Transfer in Fixed Bed Reactors with Small Tube to Particle Diameter Ratio
Authors: Eppinger Thomas , Jurtz Nico , Kraume Matthias
Published: April 2021

Fixed bed reactors are widely used in the chemical, nuclear and process industry. Due to the solid particle arrangement and its resulting non-homogeneous radial void fraction distribution, the heat transfer of this reactor type is inhibited, especially for fixed bed reactors with a small tube to particle diameter ratio. This work shows that, based on three-dimensional particle-resolved discrete element method (DEM) computational fluid dynamics (CFD) simulations, it is possible to reduce the maldistribution of mono-dispersed spherical particles near the reactor wall by the use of macroscopic wall structures. As a result, the lateral convection is significantly increased leading to a better radial heat transfer. This is investigated for different macroscopic wall structures, different air flow rates (Reynolds number Re = 16 ...16,000) and a variation of tube to particle diameter ratios (2.8, 4.8, 6.8, 8.8). An increase of the radial velocity of up to 40%, a reduction of the thermal entry length of 66% and an overall heat transfer increase of up to 120% are found.