bluuebunny/crossref_metadata_2025 huggingface dataset:
Infiltration of Bupivacaine In Liver Bed Versus Preperitoneal Intercostal Nerve Block In Laparoscopic Cholecystectomy
Authors: Haider Sohaib , Aziz Rizwan , Aziz Munazzah , Rehman Atiq-ur- , Akbar Waleed , Muzammil Manal
Published: December 2024

Background: Laparoscopic cholecystectomy is now considered the preferred treatment for symptomatic gallstone diseases, establishing itself as the gold standard method. Nevertheless, pain remains the sole grievance responsible for delaying discharge.
Objective: To compare the effectiveness of bupivacaine infiltration at the port site with its instillation into the liver bed and peritoneal cavity in reducing pain after laparoscopic cholecystectomy.
Materials and Methods: This prospective randomized study was done at the Department of General Surgery of Akbar Niazi Teaching Hospital, Islamabad. The study included 100 patients who were admitted for elective laparoscopic cholecystectomy between June and November 2023.Patients were randomized in two groups: Study group (Group A) and Control (Group B). After gallbladder was removed, patients in Group Agiven20 ml bupivacaine 0.5% in liver bed, and same amount of bupivacaine was infiltrated into 4 port sites. Group B was given a preperitoneal nerve block in addition to the insertion of bupivacaine into port sites. Postoperative pain assessment was conducted at 1, 6, 12, and 24 hours utilizing the Visual Analog Scale (VAS).
Results: The mean patients ages were43.88±7.8 years. Postoperative mean VAS at 1, 6 and 12 hours were decreased in Group A compare to Group B (p ≤ 0.05). Postoperatively no difference was observed in VAS at 24 hours between groups(p ≥ 0.05). The total doses mean of NSAID utilized in first 24 hours postoperatively were lower in Group Athan in Group B (p ≤ 0.05).
Conclusion: The combination of intraperitoneal instillation and port site infiltration of bupivacaine in the liver bed following laparoscopic cholecystectomy effectively reduces pain. This straightforward, cost-effective technique should be adopted to diminish early postoperative pain in all elective cases.
Maternal and Perinatal Outcomes of Induced Labor for Breech Presentations
Authors: Qazi Qudsia , Sultan SettingsShahida , Khan Noman , Wahab Samdana , Khan Hassaan
Published: December 2024

Background: Inducing labor for breech presentation is a relatively harmless and effective approach when carefully chosen for the right cases regarding both maternal and perinatal outcomes.
Objective: To determine safety of induction of labor in women with breech presentation with respect to maternal and perinatal outcomes.
Material and Methods: This descriptive case series included Para 1-5 with single alive fetus, frank or complete breech with flexed head after 37 weeks. Labor induced with prostaglandin E2 vaginal pessary either alone or with balloon catheter combination. Maternal outcomes (postpartum hemorrhage, postoperative fever, perinatal trauma and hospital stay of > 24 hrs) and neonatal morbidity APGAR scores (A/S) of <7, Neonatal Intensive Care Unit admission, any trauma and mortality were recorded.
Results: The study showed about 43 (86%) of women between age group of 18-35 years and 37(74%) with parity 1-3. Emergency cesarean section observed in 7 (14%) while vaginal delivery in 43(86%) cases. Maternal adverse outcomes observed were PPH in 4(8%)  (P= 0.50), postoperative fever3 (6%) (P =0.68), perinatal trauma 2(4%) (P =0.68), and hospital stay 9(18%) cases (P =0.84).Observed neonatal outcomes were A/S of < 7 in 5(10%) (P =0.07), Neonatal Intensive Care Unit admission in4( 8%) (P =0.59), injury to humorous in 1(2 %)P =0.64)case.
Conclusion: Induction of labor for term breech showed no statistically significant change in feto-maternal outcomes with regard to mode of delivery
Evaluation of Maternal and Fetal Outcomes in Caesarean Delivery Utilizing Vacuum Assistance following Pelvimetry: A Cross- Sectional Study
Authors: Ayub Najma , Mumtaz Anila , Masaud Atikka , Nabi Bushra
Published: December 2024

Background: The use of Caesarean section has greatly increased globally in the past decades, exceeding the threshold recommended by WHO even when done medically or for elective purposes. 
Objective: To evaluate the maternal and fetal outcomes in caesarean delivery utilizing pelvimetry and vacuum assistance.
Material and Methods: This cross-sectional study was done in a HBS General Teaching Hospital, Islamabad with 180 pregnant women as subjects. The study was approved by the IRB. 80 C-sections were done using vacuum assistance following pelvimetry. All the patients were given planned C-sections because of no uterine activity and amniotic fluid.Results: No significant differences were observed between the two groups in terms of mean age, parity, or mean birth weight. The results also demonstrated that there wasn't a significant difference in how much blood the mothers lost between the two groups (p=0.07). However, the size of the cut made in the mother's womb (uterine incision) was noticeably different between the two groups. There weren't any differences between the babies in the two groups when it comes to their health scores (Apgar scores) at one and five minutes after birth (p=0.06). Additionally, there wasn't a difference in the number of babies who needed special help breathing (neonatal resuscitation) or who needed to be admitted to a special care unit (SNCU) (p=1.01).
Conclusion: Vacuum-assisted Caesarean delivery is more effective than manual extraction in minimizing blood loss, uterine incision extension, and maternal discomfort during Caesarean section
Role Of Fine Needle Aspiration Cytology In Differentiation and Management of Solitary Thyroid Nodule.
Authors: Khattak Mohammad Sajjad , Rehman Naseeb ur , Khan Hina , Mohammad Asim , Ullah Rafi , Ahmad Mushtaq
Published: December 2024

Background: Solitary thyroid nodule, 4% of adult population, is common finding in patients. This needs close attention to differentiate between cyst , benign or malignant neoplasm.
Objective:  To see the cytological differentiation of different solitary thyroid nodule and to manage simple thyroid cyst  by aspiration of the cyst fluid.
Materials and Methods In this Descriptive study, which was carried out in Pathology department, Khalifa Gul Nawaz Teaching Hospital Bannu.KPK, Pakistan from January, 2014 to December, 2019  Total of 58 STN were aspirated. Aspiration obtained using aseptic technique and slides prepared, stained, mounted, labeled and reported by Pathologist. The data was analyzed by using a Statistical Package for Social Sciences (SPSS) version 20 for frequencies with percentages and mean with standard deviation..
Results In this study the mean age was 34.4±11.7 years and the age range was from 15 to 70 years. The most common age group was 36-45 years followed by 46-55 years. .Male to female ratio was 2:1.5. The most common lesion was simple cyst 36(62.06%), followed by follicular lesions 18(31.03%), papillary carcinoma 03(5.17%) and anaplastic carcinoma 01(1.72%). It was simple serous cyst which had low frequency of reappearance 21.73% followed by simple hemorrhagic cyst 40% and colloid cyst 66.6% after six month follow up.
Conclusion: Simple cyst was the commonest lesion followed by follicular lesion. Aspiration can be considered as first line procedure for diagnosis and treatment of solitary thyroid cyst as most of these disappeared for six months after complete aspiration.
Müfîdî Divânı’nda Meclis Kültürü ve Unsurları Üzerine Bir Değerlendirme
Authors: Sarı Rumeysa
Published: December 2024

Asırlar süren klasik Türk edebiyatının ana muhtevası, sevgili ve âşık üzerine temellendirilmiştir. Bu temel, şairlerimiz tarafından farklı ele alış biçimlerini doğurmuştur. Ele alınan konu içerisinde yazım gereği mazmunlar ile oluşturulan edebî türler, akıllara “klasik edebiyat, hayatın neresinde?” sorusunu getirmiş böylece edebiyat ve toplum, bilhassa klasik Türk edebiyatının toplum konusunu işleyişi sorgulanmıştır. Bu sorgulayış araştırmacılar tarafından klasik edebiyat araştırmalarında, konu çalışmalarını doğurmuştur. Araştırmacıların ortak bulgularından hareketle şu sonuca varmak mümkündür: Şairler, toplumu klasik şiir anlayışıyla ele alırken sanattan uzaklaşmamış, sanat içerisinde kültürel hayatı harmanlayarak vermişlerdir. Bu çalışmada klasik edebiyatta toplumsal hayatın kullanımına bir örnek olarak, XVIII. Yüzyıl şairlerinden Müfîdî İbrâhîm Efendi Divânı ele alınmıştır. Müfîdî Divânı’nda kültürel hayat, meclis kültürüne ait mefhumlar üzerinden değerlendirilmiştir. Meclise ait unsurlar; bezmin kuralları ve özellikleri, bezm erkânı, bezmde kullanılan araçlar, mûsikî ve mûsikî makamları şairin eserinde toplumsal hayata açılan bir pencere görevini görmüştür. Çalışmada meclise ait sözcükler, Müfîdî Divânı içerisinden taranarak, toplumsal hayat ile iç içe olan kavramlar çalışmaya konu edilmiştir. Ele alınan çalışmada XVIII. yüzyıl şairi Müfîdî’nin de diğer klasik edebiyat şairleri gibi topluma sırtını dönmediği, oluşturduğu temel aşk üçgeninde toplumsal unsurları yarattığı alemi açıklamada araç olarak kullandığı anlaşılmaktadır. Şairin eserinde bezme dair işlediği kavramları çeşitlendirmesi ve kullandığı kavramların toplumsal hayatın parçası olması, bulunan bulguları destekler niteliktedir.
Anahtar Sözcükler: Klasik Türk edebiyatı, bezm, Müfîdî, divân, mûsikî
Comparison of Tele-Rehabilitation-Based Training and generic Home-Based Program in Enhancing Balance and Quality of Life in Chronic Stroke Patients: An Experimental Study
Authors: Shahid Zohaib , Dioso Regidor III Poblete
Published: December 2024

Background: Patients with chronic stroke frequently have substantial deficits in their quality of life (QOL) and balance. Conventional rehabilitation techniques, such at-home workout regimens, might not offer the individualized feedback or supervision required for the best possible outcome. A viable substitute that uses technology to provide individualized training remotely is tele-rehabilitation.
Objective: To compare the effectiveness of tele-rehabilitation-based training versus a generic home-based exercise program in enhancing balance and quality of life in chronic stroke patients.
Methods: This randomized controlled trial enrolled 42 participants aged 40-80 years, diagnosed with chronic stroke. Participants were randomly assigned to either the tele-rehabilitation group (n=21) or the control group receiving a home-based exercise program (n=21). The tele-rehabilitation group engaged in supervised sessions emphasizing core stability, balance, and strength exercises over eight weeks, while the control group performed unsupervised exercises. The Berg Balance Scale (BBS) was used to assess balance, and the Stroke-Specific Quality of Life (SS-QOL) scale measured QOL at baseline and post-intervention.
Results: Both groups exhibited significant improvements in balance and QOL post-intervention. The tele-rehabilitation group showed a more significant enhancement in both outcomes compared to the home-based group, with statistical significance (p<0.05) achieved for both balance and QOL scores.
Conclusion: Tele-rehabilitation is an effective intervention for improving balance and quality of life in chronic stroke patients, providing greater engagement and tailored feedback than generic home-based programs.
Arapça Şiir Yazan Osmanlı Şairleri: Osmanlı Müellifleri Adlı Eserin “Şuarâ Faslı” Özelinde Bir Araştırma
Authors: Bağdat Yusuf
Published: December 2024

Bu araştırma, Osmanlı’da kesinlikle bir ilim dili olan Arapçanın, Osmanlı edebiyatı ve şiirindeki yerini sorgulamaktadır. Bu amaçla makalede Arapça şiir yazan Osmanlı şairleri, Bursalı Mehmed Tahir’in (ö. 1925) Osmanlı Müellifleri adlı eseri özelinde incelenmiş ve günümüze ulaşan Arapça şiirlerinden örnekler sunulmuştur. Osmanlı Müellifleri adlı eserin seçilmesinde etkili olan nedenler arasında, eserin Osmanlı Devleti’nin son yıllarına ait olması ve biyografisine yer verilen şahsiyetlerin uzmanlık alanlarına göre tasnif edilmesi (âlim, şair vb.) sayılabilir. Osmanlı edebiyatında Arapça şiir olgusu ile ilgili yeterince akademik çalışma bulunmaması, bu araştırmanın temel motivasyonunu oluşturmaktadır. Araştırmanın sonucunda, Osmanlı Müellifleri adlı eserin şuarâ faslında tanıtılan 14 şairin Arapça şiir yazdığı, bunlardan 9'unun şiirlerinin günümüze ulaştığı tespit edilmiştir. Şuarâ faslında yalnızca şair kimliği baskın olan şahsiyetlerin tanıtıldığı ve Arapça şiirler yazdığı halde bu fasılda yer verilmeyen daha pek çok kişi olduğu da hesaba katıldığında, Arapçanın Osmanlı’da bir ilim dili olmasının yanı sıra, aynı zamanda bir şiir ve edebiyat dili olduğunu söylemeye olanak tanıyan verilerin mevcut olduğu anlaşılmıştır. Ayrıca Osmanlı edebiyatında Arapça şiir olgusunun, farklı bağlam ve düzeylerde akademik araştırmalara uygun olduğu görülmüştür.
Crista Galli Morphometry and Morphology in Sagittal Skeletal Malocclusions: A Retrospective Cross-Sectional Study
Authors: Öztürk Taner , Uçaker Yunus Emre , Çukurluoğlu Aykağan
Published: December 2024

Objective: This study aimed that examine the relationship between crista galli morphometry and morphology in different types of sagittal skeletal malocclusion.
Materials and Methods: A total of 45 individuals included in the study were examined by dividing them into three subgroups Class I, Class II, and Class III, which included an equal number of samples according to the ANB°. In this study, different morphologies (teardrop, tubular, ossified) and morphometric (length, width, height) measurements of the crista galli were analyzed in adult patients with different sagittal malocclusions.
Results: When linear measurements of the crista galli were evaluated, no difference was found between skeletal malocclusion classes in terms of width and height. On the other hand, while the crista galli length is significantly larger in Class I individuals (13.131.93 mm) than in Class III individuals (11.561.26 mm), it is of similar size in Class II individuals (11.672.28 mm). There is no significant relationship between crista galli morphology, Keros classification and crista galli pneumatization and skeletal malocclusion groups.
Conclusion: The anteroposterior crista galli length of skeletal class II and III individuals is less than that of skeletal class I individuals. Crista galli morphology does not differ according to sagittal skeletal malocclusions.
Assesment of Youtube™ Videos about all-on-four implant supported fixed prostheses maintenance using the Global Quality Score, the DISCERN tool, and Journal of American Medical Association benchmarks
Authors: Akçin Elif Tuba , Ateş Gül
Published: December 2024

Objectives: The aim of the study is to evaluate the information on “all-on-four fixed implant prostheses maintenance” videos shared on Youtube.
Materials and Methods: A search was made on YouTube at 09:00 on August 14, 2023, with the search term "all-on-four fixed implant prostheses maintenance". Videos uploaded in the last year are sorted by relevance. The first 60 videos were viewed and analyzed for content by 2 independent prosthodontists. GQS (Global Quality Score), DISCERN, and JAMA (Journal of the American Medical Association) scales were used for the evaluation of the videos.
Results: Some of the videos obtained for the study were excluded from evaluation because they did not meet the "all-on-four fixed implant prostheses maintenance" requirements (n=39). A statistically significant relationship was found between GQS scores and DISCERN scores (p
Écriture-traduction et poétique hétérolingue dans 'Munyal, les larmes de la patience' et 'Mistiriijo : la mangeuse d’âmes' de Djaïli Amadou Amal
Authors: Atouga Jean Pierre
Published: December 2024

La présente réflexion s’intéresse à la technique d’écriture mise en œuvre dans l’œuvre romanesque de Djaïli Amadou Amal pour exprimer la poétique de l’oralité africaine. Elle questionne en particulier la place qu’occupe la traduction dans un univers de fiction hétérolingue où coexistent le fulfulde et le français. L’article pose en hypothèse que, pour venir à bout de la résistance qu’opposent ses textes à la réception, et permettre au lecteur de s’accoutumer au dépaysement de sa langue, la romancière établit une complicité avec ce lecteur plurilingue pour qui la lecture elle-même reste un acte de traduction. Elle facilite cette lecture au moyen des notes par le renvoi en fin de volume et par l’appel en bas de page. Aussi l’étude vise-t-elle à montrer que l’écriture-traduction que donne à lire cette auteure constitue un moyen permettant une intercompréhension entre les cultures française et soudano-sahélienne. L’étude convoque, pour ce faire, la théorie de l’hybridité culturelle de Bhabha (1994), laquelle permet de comprendre comment l’écriture romanesque en contexte postcolonial se nourrit du métissage et d’hybridité sur les plans textuel et sémantique.
Le « personnage écologique » amoureux dans 'Ça raconte Sarah' de Pauline Delabroy-Allard (2018)
Authors: Schmid Alicia
Published: December 2024

Dans le présent article, l’objectif est d’observer la construction d’un personnage amoureux à partir d’un angle écologique : la narratrice homodiégétique de Ça raconte Sarah de Pauline Delabroy-Allard publié aux Éditions de Minuit en 2018. Les notions de « personnage écologique » (Stéphanie Posthumus), de « mesh » (Timothy Morton) et de « nœuds phénoménologiques » (Camille Froidevaux-Metterie) sont mobilisées pour proposer une lecture écologique et féministe du roman. Il présente un amour passionnel entre deux femmes, et plus particulièrement un « devenir lesbien » (Margot Lachkar), qui bouleverse l’identité au point de transformer les représentations des personnages. Nous mettons alors en évidence une modalité fantastique qui sert à narrer les événements traumatiques lorsque la mort de la femme aimée se profile. En dernier lieu est interrogée l’influence de la fiction et de la critique sur les représentations symboliques des lectrices et des lecteurs.
Silence in the darkness
Authors: Melay Alexandre
Published: December 2024

Entre les grandes artères des périphéries urbaines, tout un tissu naturel tente de se maintenir à l’abri de son anéantissement. Nombreux sont ces lieux, des espaces déserts, présents dans des zones industrielles inoccupées, qui sont exclus — hors champ, hors cadre. Il s’agit d’un paysage bouleversé, appartenant à une nature incultivée, devenu un vestige obsolète, vétuste, retardataire, et presque sauvage au milieu de la civilisation urbaine. Dans la série photographique Silence in the darkness, l’image prend l’espace pour objet, c’est l’âme du lieu sans âme qui est mis en scène. Les photographies représentent un non-lieu photographique ; les images d’un territoire anonyme, d’une zone tampon, alternative, d’un espace intermédiaire ou intercalaire, d’une extrême banalité, en marge des métropoles. Friches industrielles, faites de terrains vagues, de routes désertent, représentent de réelles zones de partage où règne l’immobilité, l’absence. Des lieux transitoires et fonctionnels, mais aussi lieux d’errance, en suspens. Entre réalité et fiction, entre réalité sociale et imaginaire poétique, entre documentaire et fiction. Dès lors, ces lieux n’appartiennent plus aux villes, dont ils sont exclus, victimes de la modernité qui les traversent aujourd’hui. Devenus des ruines anachroniques, entachés par le retard de leur évolution dans le temps, ils symbolisent la complexité de ces lieux. Les photographies interrogent le statut même de ces zones indéterminées, oubliées, des espaces en attentes où règne le silence ; le temps semble comme suspendu, amplifiant l’immobilisation de l’atmosphère. Il émerge de ces images des espaces incertains, inconscients, semblant surgir de nulle part ; véritables lieux à l’abandon, privés de toute présence humaine. Zones à la fois bétonnées et boisées, éclairées avec la lumière orangée des réverbères sous une nuit d’hiver. Les différentes couleurs qui explorent les nuances de l’atmosphère urbaine, de l’oasis de lumière des réverbères fonctionnant à la vapeur de sodium, créent un univers livide et décoloré, entre le crépuscule, la tombée de la nuit et l’obscurité, où les arbres finissent par devenir silhouettes. Une atmosphère pesante, dans cet environnement lumineux, qui finit par plonger le spectateur, dans un espace d’anxiété, immergé dans une sensation oppressante. La sensation de malaise est accentuée par cette atmosphère à lalumière blafarde, véritables jets de lueurs d’éclairages publics. Ces environnements inondés, presque irradiés par cette clarté orangée des réverbères, forment un espace à part, mystique, magique, mais aussi funèbre, austère et sinistre, provoquant une certaine inquiétude, une sensation d’étrangeté, dans un univers déstabilisant. Face à ces images photographiques, nous sommes en proie à plusieurs réactions sur ce que l’on voit, sur ce que l’on ressent ; nous tentons de donner un sens au lieu, une signification à tous ces lieux en marges, ces friches, ces lieux intermédiaires au statut ambigu. En fait, de le comprendre, d’en déceler ses énigmes cachées, pour lui arracher ses secrets.
Lightning protection of the 110 kV substation at the wind park Ivan Sedlo against transients caused by direct lightning strikes into connected overhead line
Authors: Banjanin Mladen , Crnovčić Velibor , Tomšič Mihael
Published: December 2024

This paper deals with the lightning protection of 110 kV substation at the wind park Ivan Sedlo against transients caused by direct lightning strikes into connected 110 kV overhead line. Lightning protection level (LPL) I as per standard IEC 62305-1 is selected for this substation to reduce probability of equipment failure to low level. Calculations are done in the EMTP-ATP software. Three critical scenarios are analysed: shielding failure at the connected 110 kV overhead line, lightning strike to the top of first tower in front of the substation and lightning strike to the top of gantry tower at the entrance to the substation. It is presented that LPL I for analysed configuration of substation can be achieved by installing two sets of surge arresters. First set of surge arresters is installed in the transmission line bay, while second set of surge arresters is installed in the transformer bay. Transferred lightning transients through the power transformer are also calculated. It is presented that one additional set of surge arresters is necessary at the 30 kV side of the power transformer, to protected it against transferred lightning transients. Energy duty of all three sets of surge arresters is calculated. At the 110 kV voltage level energy stress of surge arresters is significant and strongly depends on the substation grounding resistance value. Estimated energy stress of set of surge arresters at the 30 kV voltage level is very low.
PEER VIOLENCE AND SCHOOL SAFETY – REFLECTION ON THE REPUBLIC OF SRPSKA
Authors: Lalić Velibor , Lipovac Milan
Published: December 2024

Peer violence and school safety have always been relevant topics in society. After the tragedy that occurred at the “Vladislav Ribnikar” Elementary School in Belgrade, these issues have gained special significance and received great public attention. The loss of innocent children’s lives has prompted a reassessment of past practices in schools regarding school safety. The aim of this paper is to analyze problems related to peer violence in the Republic of Srpska. Subsequently, the authors address the issue of school safety in a broader context and, finally, discuss the justification for educating students in the field of security culture in primary and secondary schools in the Republic of Srpska.
Progress, deception, temptation, practicality.Fashion in French Enlightenment thought
Authors: Abazeva Margarita Stanislavovna
Published: December 2024

The article is devoted to the study of Enlightenment thinkers discourse about fashion. In the XVIII century, Paris finally established itself as a fashion capital on the European map. The weight of fashion in the public consciousness also increased: the first works on the history of fashion appeared, magazines and newspapers wrote about it, authors dedicated essays, plays and novels to it. Fashion was also not ignored by those whose thought had a huge impact on the society of that time — the French Enlightenment thinkers. Analyzing the works of the Enlightenment thinkers, the author reconstructs their discourse about fashion and shows what issues it raised. Two directions of thought about fashion are defined: supporters of luxury and its opponents, their views are reviewed separately. To analyze it the author uses the methodology of cultural history and methods of studying fiction literature as a historical source. The author comes to the conclusion that one can consider the XVIII century dispute about luxury as a watershed between Enlightenment thinkers in their attitude to fashion. Those of them who supported luxury and considered it an impetus for development of the country's economy favored fashion justifying its economic expediency for the state. Others, opponents of luxury, did not approve fashion and sought to show its harmful effect on a man and society. The author shows how the opponents of luxury formed in their works a whole system of ideas about fashion and costume, which then became part of the ideological doctrine of the future sartorial revolution. The article contributes to the study of the history of French fashion of the XVIII century and may be of interest to a wide range of readers interested in the history of fashion and the Age of Enlightenment in France.
The fate of pyruvate dictates cell growth by modulating cellular redox potential
Authors: Toshniwal Ashish G , Lam Geanette , Bott Alex J , Cluntun Ahmad A , Skabelund Rachel , Nam Hyuck-Jin , Wisidagama Dona R , Thummel Carl S , Rutter Jared
Published: December 2024

Pyruvate occupies a central node in carbohydrate metabolism such that how it is produced and consumed can optimize a cell for energy production or biosynthetic capacity. This has been primarily studied in proliferating cells, but observations from the post-mitotic
Drosophila
fat body led us to hypothesize that pyruvate fate might dictate the rapid cell growth observed in this organ during development. Indeed, we demonstrate that augmented mitochondrial pyruvate import prevented cell growth in fat body cells
in vivo
as well as in cultured mammalian hepatocytes and human hepatocyte-derived cells
in vitro
. This effect on cell size was caused by an increase in the NADH/NAD
+
ratio, which rewired metabolism toward gluconeogenesis and suppressed the biomass-supporting glycolytic pathway. Amino acid synthesis was decreased, and the resulting loss of protein synthesis prevented cell growth. Surprisingly, this all occurred in the face of activated pro-growth signaling pathways, including mTORC1, Myc, and PI3K/Akt. These observations highlight the evolutionarily conserved role of pyruvate metabolism in setting the balance between energy extraction and biomass production in specialized post-mitotic cells.
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
Authors: Coquel Flavie , Ho Sing-Zong , Tsai Keng-Chang , Yang Chun-Yen , Aze Antoine , Devin Julie , Chang Ting-Hsiang , Kong-Hap Marie , Bioteau Audrey , Moreaux Jérôme , Maiorano Domenico , Pourquier Philippe , Yang Wen-Chin , Lin Yea-Lih , Pasero Philippe
Published: December 2024

Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. This feature is exploited by cancer therapies to either increase RS to unbearable levels or to inhibit checkpoint kinases involved in the DNA damage response (DDR). Thus far, treatments that combine these two strategies have shown promise but also have severe adverse effects. To identify novel, better-tolerated anticancer combinations, we screened a collection of plant extracts and found two natural compounds from the plant,
Psoralea corylifolia
, that synergistically inhibit cancer cell proliferation. Bakuchiol inhibited DNA replication and activated the checkpoint kinase CHK1 by targeting DNA polymerases. Isobavachalcone interfered with DNA double-strand break (DSB) repair by inhibiting the checkpoint kinase CHK2 and DNA end resection. The combination of bakuchiol and isobavachalcone synergistically inhibited cancer cell proliferation
in vitro
. Importantly, it also prevented tumor development in xenografted mice. The synergistic effect of inhibiting DNA replication and CHK2 signaling identifies a vulnerability of cancer cells that might be exploited by using clinically approved inhibitors in novel combination therapies.
Flamingo participates in multiple models of cell competition
Authors: Sanchez Bosch Pablo , Cho Bomsoo , Axelrod Jeffrey D
Published: December 2024

The growth and survival of cells with different fitness, such as those with a proliferative advantage or a deleterious mutation, is controlled through cell competition. During development, cell competition enables healthy cells to eliminate less fit cells that could jeopardize tissue integrity, and facilitates the elimination of pre-malignant cells by healthy cells as a surveillance mechanism to prevent oncogenesis. Malignant cells also benefit from cell competition to promote their expansion. Despite its ubiquitous presence, the mechanisms governing cell competition, particularly those common to developmental competition and tumorigenesis, are poorly understood. Here, we show that in Drosophila, the planar cell polarity (PCP) protein Flamingo (Fmi) is required by winners to maintain their status during cell competition in malignant tumors to overtake healthy tissue, in early pre-malignant cells when they overproliferate among wildtype cells, in healthy cells when they later eliminate pre-malignant cells, and by supercompetitors as they compete to occupy excessive territory within wildtype tissues. ‘Would-be’ winners that lack Fmi are unable to overproliferate, and instead become losers. We demonstrate that the role of Fmi in cell competition is independent of PCP, and that it uses a distinct mechanism that may more closely resemble one used in other less well-defined functions of Fmi.
Estado vegetal: el intento de un teatro poshumano
Authors: Gutiérrez Silva Francisco
Published: December 2024

La obra Estado Vegetal (2017) de Manuela Infante se enmarca en un proceso de reflexión estética y filosófica de la dramaturga a propósito de la teoría poshumana. En ese sentido, existen una serie de claves, temas y motivos en la obra que encarnarían un teatro poshumano. Sin embargo, el presente ensayo planteará que junto, o por sobre el planteamiento filosófico poshumano, la obra nos presenta una crítica al contexto artístico y político en el cual se instala.
Elementos de la ciencia ficción como suscitadores de problemáticas políticas contemporáneas en Liceo de niñas de Nona Fernández
Authors: Tapia Marín Felipe
Published: December 2024

La obra de Nona Fernández posee un sello distintivo orientado principalmente a retratar una generación que vivió durante el periodo de la dictadura y adquirió cicatrices y traumas que permanecieron al albor de la democracia. No obstante, Liceo de niñas (estrenada en 2015 y publicada en 2016), además de ese sello, incorpora la ciencia ficción para vislumbrar un encuentro entre dos épocas y generaciones. Dicho subgénero funciona como una herramienta que permite contrastar semejanzas y diferencias, operando como un catalizador de cuestionamientos sociales y políticos. Este documento busca indagar de qué forma la ciencia ficción permea los rasgos más elementales de la obra Liceo de niñas para retratar las problemáticas de una generación que vivió la represión durante y después de la dictadura.
“Deriv. Secreta. Secretear. Secretaria”: sobre trayectos y despojos de Gabriela Roepke en Chile, España y Estados Unidos (ca. 1943-1993)
Authors: Aliaga Araneda Sergio
Published: December 2024

Este ensayo analiza la trayectoria de Gabriela Roepke, destacando los conceptos de despojo y desplazamiento como claves de su práctica artística. A partir de la etimología de “secreto” de Joan Corominas, se argumenta que Roepke desarrolló una metodología creativa basada en el abandono de ciertos elementos para reconfigurar su producción teatral. Figura central del teatro universitario chileno (1941-1973), Roepke jugó un rol crucial en la gestión y proyección internacional del teatro. El estudio aborda tres etapas: Santiago, Madrid y Nueva York. A través del estudio de su archivo disperso, se revela una estrategia en la que el abandono se convierte en un mecanismo de creación.
Paisajes y recorridos en el teatro brasileño contemporáneo: entre el cielo y el asfalto
Authors: Wilker Francis , Veloso Verônica
Published: December 2024

Este artículo presenta una reflexión en torno a las relaciones entre teatro y espacio urbano a partir de un recorte de la escena brasileña contemporánea. Para ello, propone un paisaje con creaciones de diferentes regiones de Brasil y presenta algunas nociones conceptuales desarro- lladas en investigaciones dedicadas al tema. La emergencia del espacio en la escena es trazada tomando la transición entre los siglos XX y XXI (1992-2020) como marco temporal, y abarca los impactos de la pandemia de Covid-19 en esta producción interesada en la composición con el espacio urbano. En diálogo con la práctica escénica y conceptos como teatro de invasión, puesta en escena en deriva y puesta en escena-paisaje, configura una cartografía que pone de relieve las operaciones composicionales presentes en estas creaciones y señala los rasgos recurrentes en el horizonte actual del teatro brasileño, donde se identifica el debilitamiento de la investigación del espacio y un énfasis en la presencia de cuerpos históricamente relegados.
Geleneksel Çocuk Oyunlarının Matematik Öğretiminde Kullanılması Hakkında İlköğretim Matematik Öğretmeni Adaylarının Görüşleri
Authors: Topan Beyda
Published: December 2024

Bu çalışmada geleneksel çocuk oyunlarının matematik öğretiminde kullanılması hakkında ilköğretim matematik öğretmeni adaylarının görüşlerinin incelenmesi amaçlanmıştır. Oyunlarla yapılan öğretimin pek çok yönden katkılarının olduğu yapılan çalışmalarla ortaya koyulmuştur. Kültür ve geçmişle bağlantı kurulmasında köprü görevi gören geleneksel çocuk oyunlarının matematik öğretiminde kullanılabilirliği, yeri, etkileri gibi farklı boyutlar merak edilmiş ve öğretmen adaylarının bu oyunlara yönelik görüşleri araştırılmıştır. Bu amaç doğrultusunda, mevcut araştırma durum çalışması yöntemine göre planlanmıştır. Araştırmanın katılımcılarını, bir devlet üniversitesinin ilköğretim matematik öğretmenliği programında öğrenim gören 26 öğretmen adayı oluşturmuştur. Öğretmen adaylarının görüşleri almak amacıyla açık uçlu sorulardan oluşan yarı yapılandırılmış görüşme formu kullanılmıştır. Öğretmen adaylarının görüşleri yazılı olarak alınmıştır. Formdan elde edilen verilerin analizinde içerik analizi kullanılmıştır. Öncelikle kodlar çıkarılmış, daha sonra temalar oluşturulmuştur. Elde edilen analiz sonuçlarına göre, öğretmen adaylarının geleneksel çocuk oyunlarının matematik öğretiminde kullanılabileceğine yönelik ortak görüş bildirdikleri görülmüştür. Öğretmen adayları çoğunlukla geleneksel çocuk oyunlarının matematik öğretiminde kullanılmasına ilişkin olumlu yönde görüş bildirirken olumsuz görüşlere de rastlanmıştır. Genel olarak öğretmen adaylarının görüşleri öğrenme-öğretme, öğrenci, mesleki gelişim, sosyal beceri, oyun ve kültür olmak üzere 6 tema altında toplanmıştır. En çok görüş öğrenme-öğretme teması altında toplanırken en az görüş kültür teması altına yerleştirilmiştir. Çalışmadan elde edilen sonuçlara göre geleneksel çocuk oyunlarının matematik öğretiminde farklı öğretim kademelerinde kullanılabileceği önerilmektedir.
Afet Bilinci Dersi Özgün Ve Resmi Program Uygulamasına Yönelik Bir Durum Çalışması
Authors: Uçkan Pınar
Published: December 2024

Çalışmanın amacı, 2023-2024 eğitim öğretim yılının başlangıcında yayınlanmış öğretim programı bulunmayan ancak muhatapları bulunan Afet Bilinci seçmeli dersine ait özgün ve geçici olarak hazırlanan öğretim programlarının çerçevesini ortaya çıkarmak, resmi program ile karşılaştırmasını yapmak ve programla ilgili öğretmen görüşlerini alabilmektir. Nitel araştırma deseniyle yürütülen çalışmanın örneklem grubunu 2023-2024 eğitim öğretim yılında Çorum ilinde seçmeli Afet Bilinci dersini okutan 7 katılımcı oluşturmuştur. Verilerin toplanmasında yarı yapılandırılmış görüşme formu ve doküman incelemesi tercih edilmiştir. Araştırma kapsamında Afet Bilinci dersini okutan öğretmenlerin kendi hazırladıkları özgün ve geçici programlara ulaşılmıştır. Öğretmenlerin kendi hazırladıkları özgün program ile bakanlıkça ilan edilen resmi program içerik ve öğrenme – öğretmen süreçleri yönünden karşılaştırılmıştır. Katılımcı öğretmenlerin program hazırlama süreçleri ve uygulama esnasında karşılaşılan durumlarla ilgili görüşleri alınmıştır. Hazırlanan görüşme formu iki ayrı uzman tarafından değerlendirmeye alınmış, gerekli düzeltmeler yapılarak görüşme formuna son hali verilmiştir. Çalışma sonucunda öğretmenlerin kendilerini program yazma ve uygulama konusunda yeterli gördükleri tespit edilmiştir. Bununla birlikte öğretmenlerin konu içeriği belirlemede güçlük yaşadıkları ve programsız seçmeli ders seçiminden kaçındıkları saptanmıştır. Öğretmenlerin kendi hazırladıkları özgün programların içeriğinin resmi programa göre daha yoğun ve güncel olduğu sonucuna varılmıştır. Çalışmanın bulguları doğrultusunda öğretmen yeterlilik ve özerkliklerinin geliştirilmesi için gerekli çalışmaların yapılması, Afet Bilinci dersinin okullarda yaygınlaştırılması ve düzeye uygun afet eğitimlerinin verilmesi önerilmiştir.
Case of Ovarian Hyperstimulation Syndrome with Ovarian Torsion: An Unusual Complication of Primary Untreated Hypothyroidism
Authors: Fernandes Gwendolyn , Patil Manali , Thomson Caroline
Published: December 2024

Ovarian Hyperstimulation Syndrome (OHSS) is an extremely unusual complication of ovarian induction therapy given for infertility. OHSS can also occur spontaneously in ovulation cycles linked to polycystic ovarian disease, multiple gestations, molar pregnancy, pituitary adenomas and very rarely, hypothyroidism. It can result in significant morbidity and mortality in severe forms due to thrombosis and organ failure. A 28-year-old non pregnant woman presented to the emergency services with severe abdominal pain associated with nausea, vomiting, constipation and burning micturition. The symptoms began four to five days ago and the pain, which was initially localised to the left iliac fossa, progressed to involve the entire abdomen. Ultrasonography revealed large, bulky, oedematous ovaries with multiple cysts of varying sizes, indicative of OHSS, along with torsion of the left ovary. There was no history of receiving beta-human Chorionic Gonadotropin (β-hCG), clomiphene citrate, estradiol, oral contraceptive pills, or any other ovulation induction therapy. A salpingo oophorectomy was done for the left ovary and cystectomy with ovarian reconstruction was done for the right ovary. Histopatholgical examination confirmed OHSS (Type 3) with ovarian torsion. The patient had a diagnosis of primary hypothyroidism during pregnancy which was three and half years ago and was treated with Thyroxine 75 μg per day. However, stopped thyroxine on her own immediately after delivery. Thyroid Stimulating Hormone (TSH) levels was 110 μg, T3 was 16 ng/mL and T4 was 0.91 μg/dL. Thyroxine 100 μg/day was started and the contralateral ovary returned to the normal size on ultrasonography within a period of three months. Thus, OHSS resulted from primary hypothyroidism and was cured with thyroid hormone replacement. OHSS may also be considered in the differential diagnosis in patients of hypothyroidism patients presenting with abdominal symptoms.
A Case of Neuroretinitis in a Young Male Section Triggered by Cat Scratch Disease
Authors: Vatkar Vishakha , Bora Riddhi Ajay , Goyal Khushboo , Agrawal Tushar , Pokle Supriya
Published: December 2024

Neuroretinitis is a potentially vision-threatening condition characterised by the swelling of the optic disc, followed by the development of a macular star due to the spread of fluid to the surrounding peripapillary retina. The present case report describes a rare case of unilateral neuroretinitis in a 36-year-old male who presented with an acute, painless decrease in vision in the right eye. The patient exhibited classic signs of neuroretinitis, such as optic disc oedema and a macular star. A systemic work-up ruled out most infectious and inflammatory causes, while serological tests for Cat Scratch Disease (CSD) showed highly reactive results. He was immediately started on appropriate oral antibiotics and steroids for six weeks, after which he experienced significant visual recovery. Managing neuroretinitis involves early investigation, addressing the underlying infection and mitigating the inflammatory response. Challenges include the need for accurate and timely diagnosis, often requiring serological tests and imaging studies. Notably, the present case underscores the importance of considering Bartonella henselae infection in the differential diagnosis of neuroretinitis, particularly in patients with a history of cat exposure. The rarity of such presentations in otherwise healthy young individuals highlights the need for increased awareness and prompt diagnostic evaluation to ensure optimal outcomes and prevent long-term visual impairment.
Factors Influencing Coastal Ecosystem Services and Societal Impacts in Ilaje, Ondo State, Nigeria
Authors: ADEBUSOYE Adewole Ayodeji. , FADAMIRO J. Akinlabi. , OGUNBANWO Babatunde Michael,
Published: December 2024

Background: The global population is projected to reach nearly 10 billion by 2050. Human activity over time has increased along the world's coastlines. The more humans increase, the more danger to the coastal landscapes. The need to address this population issue is made more urgent by the fact that growing human activity has drastically changed the natural ecosystem and the services it offers.
Study Aim: The aim of study is to investigate the factors that influences the ecosystem services of coastal landscapes and its societal impact of Ilaje Local Government Area, Ondo state.
Methods: The study utilized a quantitative research method, a cross-sectional community-based survey, with a sample size of 505 respondents from three main communities, Mahin, Ugbo, and Ugbonla. We collected using a structured questionnaire and analyzed using descriptive (Mode) and inferential statistical methods (Chi-square, Spearman's rho Correlation Coefficient and Ordinal regression analyses) using statistical package for social sciences (SPSS).
Results: The study discovered the following factors affecting the ecosystem services of coastal landscapes in the study area:  widespread and increasing pressure on marine and coastal resources, the prohibited use of these resources for places like the hideouts of militants, kidnappers, and smugglers, the misuse of these resources for public markets, and the abandonment of rickety and spoilt ships and boats. The results showed that illegal uses, such as hiding places for terrorists, kidnappers, and smugglers, had a detrimental effect on ecosystem services' ability to provide clean water, air to people in the environment and detrimental influence on the environment's ability to promote human well-being and healthy living.
Recommendation: Based on the findings, it is recommended that the administration of Ondo State should work with the Ministry of Blue Economy to combat the unauthorized use of Ilaje LGA's coastal landscapes in order to develop them for tourism and hospitality enterprises and generate income as a consequence of economic diversification. This will help in achieving the United Nations Sustainable goals 1, 8, 9, 11, 12 and 14.
Using Combined Nutrient Management Practices to Maximize Yields, Nutrient Uptake, and Balance for Rice-Rice Cropping Systems
Authors: Rashid M M , Islam M S , Manir M R , Rahaman M S , Hera M H R , Begum S , Shalahuddin A K M
Published: December 2024

An on-site experiment was carried out at the Bangladesh Rice Research Institute (BRRI). The objective was to assess the most appropriate blend of organic and inorganic fertilizers for the Boro-Fallow-Transplanted Aman rice cropping pattern. An experiment was carried out at the BRRI Farm in Gazipur, Bangladesh to assess rice yields, nutrient absorption, and balance. The nutrient management practices included absolute nutrient control (T1), the recommended chemical fertilizer dose by BRRI (T2), a combination of kitchen waste (3 t/ha) and 50% of the recommended BRRI fertilizer dose (T3), a combination of cow dung bio-slurry (3 t/ha) and 50% of the recommended BRRI fertilizer dose (T4), and a combination of poultry litter (3 t/ha) and 50% of the recommended BRRI fertilizer dose (T5). The practices were evaluated using a randomized complete block design with three replications conducted over two consecutive years. The performance of Poultry litter with 50% BRRI-recommended fertilizer (T5) and BRRI-recommended fertilizer dosage (T2) has been superior in all parameters. The same approaches (T5) and (T2) demonstrated the highest absorption of nutrients by rice crops. The observed N and K balance exhibited a negative trend but with a lesser degree of negativity. Additionally, a lower level of deficit was seen in the T5 treatments. The T5 treatment exhibited a surplus of P, while other treatments showed a deficit of P. This research shows that poultry litter (3 t/ha) combined with 50% of the fertilizer suggested by BRRI is enough and acceptable for a sustainable rice yield.
Influence of Soil Texture on the Mineralization of Sulphur Nanoparticles under Incubation
Authors: Choudhary Priyanka , Patel K.C. , Lakshman  , Sunda Rakesh , Singh Praveen , Yadav Suwa Lal
Published: December 2024

Background: Nanotechnology has a great potential for achieving sustainable agriculture. Nano sulphur is highly homogeneous in the distribution to the ground with an average particle size of within 100 nm.
Study Design & Place: An incubation study was conducted at the laboratory, Micronutrient Research Centre, AAU, Anand, to study the effect of sulphur nanoparticles over conventional sulphur source on sulphur availability up to 60 days.
Methodology: Incubated soils were studied with the different levels of sulphur NPs in loamy sand and clayey soil at an interval of time i.e., 10, 20, 40 and 60 days. The soils were treated with four levels of sulphur nanoparticles (0, 2, 4 and 8 mg S/kg soil) and one level of 8 mg S/kg soil through Elemental S. The each set (40) was completely withdrawn after 10, 20, 40 and 60 days and was analyzed for 0.15% CaCl2-extractable sulphur.
Results: This lab study was stated that availability of sulphur up to 60 days in loamy sand soil was found higher with T5 (8 mg S/kg soil through ES) was 20.30 ppm at 40 days. In case of clay soil higher with T4 (8 mg S/kg soil through SNPs) was 64.34 ppm at 40 days. In case of fractionation at 60 days of incubated loamy sand soil, all forms of sulphur was found higher with T4 (8 mg S/kg soil through SNPs) except sulphate sulphur and non-sulphate sulphur. In case of clay soil fractionation all forms of sulphur was found with T4 (8 mg S/kg soil through SNPs) except non-sulphate sulphur. All forms of sulphur was found higher in SNPs treatments except non-sulphate sulphur in both loamy sand and clay soils. Under incubation study, the periodical availability of sulphate sulphur was found increasing pattern up to 40 days after application in soil and thereafter in declining trend in both soils and source of sulphur. Hence, looking to the overall observations, the sulphur nanoparticles proved better in increasing the periodical availability of sulphur as compared to elemental sulphur in loamy sand and clay soils.