bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of mid-intestinal microbiota of farmed Chinook salmon using 16S rRNA gene metabarcoding
Authors: Ciric Milica , Waite David , Draper Jenny , Jones John
Published: July 2019

With the growing importance of aquaculture worldwide, characterization of the microbiota of high-value aquaculture species and identification of their shifts induced by changes in fish physiology or nutrition is of special interest. Here we report the first 16S rRNA gene metabarcoding survey of the mid-intestinal bacteria of Chinook salmon (Oncorhynchus tshawytscha), an economically important aquacultured species. The microbiota of 30 farmed Chinook salmon from a single cohort was surveyed using metabarcode profiling of the V3-V4 hypervariable region of the bacterial 16S rRNA gene. Seawater, feed and mid-intestinal samples and controls were sequenced in quadruplicate to assess both biological and technical variation in the microbial profiles. Over 1000 operational taxonomic units were identified within the cohort, providing a first glimpse into the mid-intestinal microbiota of farmed Chinook salmon. The taxonomic distribution of the salmon microbiota was reasonably stable, with around two thirds of individuals dominated by members of the family Vibrionaceae. We anticipate that the workflow presented in this paper could be applied in other aquacultured fish species to capture variation or dysbiosis occurring as a result of changes in feed, health or environmental conditions.
Transitions to adulthood in flux. Assessing coming of age through an historical lens in Finland and France
Authors: Mary Aurelie
Published: July 2019

According to youth experts, a significant number of contemporary young people
in Western societies reach adulthood at a later age than previous
generations. This phenomenon is generally perceived as a temporary misstep
on the path to default patterns of transition established in the 1950s and
1960s. Given the current societal context, should the transition to adulthood
today really conform to that model? This paper provides an historical
analysis of transitions to adulthood to enquire whether the post-war model
can still be considered a meaningful reference today. Were routes of
transition similar or different in earlier times, or has the model always
existed? To answer this question, the paper looks at demographics in two
case countries, Finland and France, in three periods: the nineteenth and
early twentieth centuries, the 1950s-1970s, and the early twenty-first
century. The paper argues that the post-war generation?s rapid patterns of
transition w ere unique, resulting from a sustained period of economic
growth in developed societies. This has generated new pathways of transition
and a model of adulthood still used as a standard point today, even though
the current socio-economic context has changed. Transitions to adulthood are
not static. They have always evolved, mirroring the wider historical context
within which individuals operate.
Challenges and life orientations of youth. The context of transition countries
Authors: Szafraniec Krystyna
Published: July 2019

This paper focuses on the life orientations of youth living in postcommunist
countries. Although a large part of them function today within the same
global organism, their political past still differs them from the other
countries, defining in a special way all the socialization space the youth
grow up in. The analyses undertaken in this paper try to argue that this is
not only the problem of the political heritage, but much more complicated
interaction between transformation and globalization processes, that can be
described in terms of glocal space, where nothing is the same, starting with
socialization process, through life opportunities, and ending with political
significance of youth. Empirical basis are here existing data collected in
an international project covered Poland, Eastern Germany, Latvia, Hungary,
Romania, Bulgaria, Russia, China and Vietnam. The analyses show life
orientations of youth - representatives of the first generation, who have
grown up intellectually within the new system - as an important driving
force of changes, on the one hand, and equally serious source of social and
political tensions, on the other, possible especially where the ?aspiration
gap? (the distance between what young people aspire to and what they can
achieve) is large and concerns considerable part of youth.
Youth cultures and style. Analytical approaches and a methodological proposal
Authors: Genova Carlo
Published: July 2019

Youth cultures are nowadays one of the main social forms among young people,
and at the core of youth cultures is style. Variously defined, style is made
up of all those elements through which each youth culture, and every
individual involved in it, expresses itself and positions itself with regard
to other cultural models, by processes of identification, distinction and
recognition. Over time, different approaches to the analysis of youth
cultures have been developed - on the basis partly of the different
empirical phenomena which have been taken into consideration, and partly of
the different sensitivities of the scholars - and thus different
interpretive perspectives of style have also emerged. The article aims at
reconstructing the core elements of the main approaches to style in the
study of youth cultures - considering definitions, constitutive elements,
and interpretive models - and then, on these bases, at reflecting about a
possible methodological path in the concrete study of today?s youth
cultures? styles.
Young returning migrants as actors of social changes in Slovakia
Authors: Hofreiter Roman , Kostialová Katarína
Published: July 2019

Migration is a cyclical process which also involves a decision as to whether
to return. The situation in Slovakia is characterised by a high number of
young people studying abroad. Up to now, the process of their migration and
return has been studied frequently from an economic perspective. However,
the return migration also contributes to social changes in the home country
of the migrants. Therefore, the return migration opens new research, areas
and themes some of which we include in our paper. In contemporary migration
studies, the transfer of new ideas, practices and codes of behaviour between
the place of origin and destination covers the concept of social
remittances. The idea of social remittances focused sociological attention
on the tendencies of returning young migrants to become bearers of change
and development in their home country. In this paper, we are presenting
findings about practical aspects how young Slovak migrants become agents of
social change in their immediate circle, community and even society.
Between “CV builder” and “Genuine” activist: The many faces of youth civic engagement in Serbia
Authors: Petrovic Jelisaveta , Stanojevic Dragan
Published: July 2019

The aim of this paper is to explore the characteristics and relative
importance of civic engagement for young members of civil society
organisations in Serbia. This article is exploratory in character and is
based on qualitative methodology. Youth engagement is observed through the
theoretical lens of the life course approach. The questions addressed by the
paper are as follows: How do young people perceive their civic engagement?
What motivates their participation? How does this engagement relate to other
aspects of their life course? The method used here is narrative analysis of
20 semi-structured interviews conducted with young volunteers and members of
civil society organisations in Serbia selected through theoretical
sampling. The key finding is that there is a range of motivations and
accompanying strategies - from the purely idealistic to the highly
instrumental. The majority of our respondents displayed a mixed type of
motivation, successfully combining activities aimed at protecting the ?social
good? with those that contribute to the achievement of personal goals.
Motivation, however, tends to vary between the different types of
organisations, professional and grassroots. Engagement in professional
organisations is more frequently instrumental and, in contrast, grassroots
organisations typically attract ?genuine?, value-driven activists.
Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial
Authors: Bril Fernando , Biernacki Diane M. , Kalavalapalli Srilaxmi , Lomonaco Romina , Subbarayan Sreevidya K. , Lai Jinping , Tio Fermin , Suman Amitabh , Orsak Beverly K. , Hecht Joan , Cusi Kenneth
Published: July 2019

OBJECTIVE

While vitamin E has shown to improve nonalcoholic steatohepatitis (NASH) in patients without diabetes, information on patients with type 2 diabetes mellitus (T2DM) is lacking. The aim of this study was to determine whether vitamin E, alone or combined with pioglitazone, improves histology in patients with T2DM and NASH.

RESEARCH DESIGN AND METHODS

This was a proof-of-concept, randomized, double-blind, placebo-controlled trial conducted from 2010 to 2016. Patients with T2DM and biopsy-proven NASH (n = 105) were randomized to vitamin E 400 IU b.i.d., vitamin E 400 IU b.i.d. plus pioglitazone 45 mg/day, or placebo. Eighty-six patients completed the 18-month study. The primary end point was a two-point reduction in the nonalcoholic fatty liver disease activity score from two different parameters, without worsening of fibrosis. Secondary outcomes were resolution of NASH without worsening of fibrosis, individual histological scores, and metabolic parameters.

RESULTS

More patients on combination therapy achieved the primary outcome versus placebo (54% vs. 19%, P = 0.003) but not with vitamin E alone (31% vs. 19%, P = 0.26). Both groups showed improvements in resolution of NASH compared with placebo (combination group: 43% vs. 12%, P = 0.005; vitamin E alone: 33% vs. 12%, P = 0.04). While steatosis assessed by histology improved with combination therapy (P < 0.001) and vitamin E alone (P = 0.018), inflammation (P = 0.018) and ballooning (P = 0.022) only improved with combination therapy. No improvement in fibrosis was observed in any group.

CONCLUSIONS

In this proof-of-concept study, combination therapy was better than placebo in improving liver histology in patients with NASH and T2DM. Vitamin E alone did not significantly change the primary histological outcome.
A FORMAÇÃO INICIAL E INICIAÇÃO À DOCÊNCIA EM QUÍMICA NA UFMT: HISTÓRIAS E EXPERIÊNCIAS
Authors: Damasceno Ribeiro Marcel Thiago
Published: July 2019

Este artigo resulta de uma pesquisa teórica sobre a formação inicial e iniciação à docência em Química na UFMT, por meio de uma análise documental, e que compôs parte do texto da pesquisa de doutorado intitulada Saberes Científicos e Pedagógicos de Conteúdo expressos por Professores Egressos do Programa de Bolsa de Iniciação à Docência em Química da UFMT, desenvolvida pela Rede Amazônica de Educação em Ciências e Matemática (REAMEC). E tem por objetivo narrar os aspectos evolutivos do curso de Licenciatura em Química do campus Cuiabá-UFMT, em diálogo com a literatura pertinente, desde sua criação até o contexto de formação do Programa Institucional de Bolsa de Iniciação à Docência (PIBID) na UFMT e o Subprojeto Química. A análise dos documentos (PPC do curso, artigos, capítulo de livros, entre outros), que compuseram o corpus da pesquisa evidencia a experiência do curso de Licenciatura em Química e o desenvolvimento do PIBID, como um lócus privilegiado para a formação de educadores químicos no Estado de Mato Grosso.
CARACTERÍSTICAS DOS TRÊS MUNDOS DA MATEMÁTICA QUE EMERGEM NA RESOLUÇÃO DE QUESTÕES ENVOLVENDO O CONCEITO DE LIMITE
Authors: Oliveira Soares Gabriel de
Published: July 2019

O conceito de limite de uma função é concebido com um dos principais e mais complexos no trabalho com as disciplinas de Cálculo Diferencial e Integral (CDI), sendo base para a aprendizagem do conceito de derivada, por exemplo. Nesse sentido, buscando compreender como alunos que já cursaram uma disciplina de CDI compreendem esse conceito, esse estudo objetiva analisar características dos Três Mundos da Matemática propostos por Tall (2004; 2013) que estudantes de dois cursos de Licenciatura em Matemática mobilizam ao resolverem questões envolvendo o conceito de limite. Para tal, foi proposto um teste com sete questões à catorze estudantes de dois cursos de Licenciatura em Matemática do estado do Rio Grande do Sul, das quais, três são analisadas nesse texto, com vistas ao quadro teórico proposto. Pode-se concluir que a maioria dos estudantes apresenta imagens conceituais fracas em relação a esse conceito, estando suas aprendizagens baseadas principalmente em características do Mundo Conceitual Corporificado.
Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cells (CAR-T) immunotherapy: a systematic review of case reports†
Authors: Zhang Xu , Sun Di , Jiang Gui-Chun
Published: July 2019

Objective

Cytokine release syndrome (CRS) and tumor lysis syndrome (TLS) that occur after chimeric antigen receptor T (CAR-T) cells are reinfused, which severely affect the survival and prognosis of patients. Although several articles have reported on the care of CAR-T cell immunotherapy, the quality of the study and the effectiveness of holistic nursing interventions have not been systematically reviewed. The purpose of this study was to systematically evaluate the existing holistic nursing interventions of CAR-T cell immunotherapy.

Methods

A literature search for keywords was performed in PubMed, EMBASE, the Cochrane Library, CNKI, CBM, and Wanfang Data from its inception until January 2018. Studies were deemed eligible if they comprised patients with tumor receiving CAR-T cell immunotherapy, described the holistic nursing process, and were published in Chinese and English.

Results

A total of 6 articles on holistic nursing interventions of CAR-T cell immunotherapy are reported, and the nursing methods and results of each article are analyzed. The quality of the studies included was medium. All nursing measures were considered effective.

Conclusions

Holistic nursing programs reduce the incidence of CRS and TLS and improve the quality of life of cancer patients.
Cross-cultural adaptation of the Management of Aggression and Violence Attitude Scale for nurse in emergency department
Authors: Chang Rui , Yang Hui
Published: July 2019

Objective

To follow the guidelines of intercultural adaptation provided by the American Academy of Orthopedic Surgeons’ (AAOS) Evidence-Based Medicine Committee, translating the original scale and evaluating the reliability and validity, and then to compile the Chinese version of the Management of Aggression and Violence Attitude Scale (MAVAS) for nurses in emergency room in the mainland of China.

Methods

This study consists of two phases of testing: (1) translation: forward translation, synthesis, back translation, expert committee review, and pretesting; (2) psychometric properties: content and construct validity, internal consistency, and test–retest reliability.

Results

The Chinese version of MAVAS and the original version showed excellent similarities and equivalence. The average Scale-level Content Validity Index was 0.904, and the Item-level Content Validity Index ranged from 0.80 to 1.00. The construct validity was tested using confirmatory factor analysis by LISREL 8.7; χ2/df of the scale was 4.781<5, NFI, NNFI, CFI, IFI>0.90, indicating that the scale’s factor structure model fitted better. The internal consistency was satisfactory (scale, Cronbach’s α=0.94; subscales, Cronbach’s α=0.74–0.90), and the test–retest reliability over 2 weeks was good (scale, Pearson’s coefficient=0.996; subscales, Pearson’s coefficient=0.801–0.963).

Conclusions

The Chinese version of MAVAS had an excellent feasibility. It was found to be a valid and reliable tool to assess nurses’ attitude toward patients’ violence in emergency department.
Effectiveness of probiotics in irritable bowel syndrome: methodological quality of meta-analyses and systematic reviews
Authors: Jia Yuan , Guo Li-Min , Yang Si-Yuan , Wu Qian , Meng Fan-Jie
Published: July 2019

Objective

This study assessed the methodological quality of systematic reviews/meta-analysis of the effectiveness of probiotics against irritable bowel syndrome (IBS) using the accepted methodological quality assessment scale AMSTAR and explored the factors that influenced the quality of methodology. It was designed to provide a reference for future research and systematic reviews/metaanalysis.

Methods

The methodological quality of existing systematic reviews/meta-analysis was evaluated using the AMSTAR scale. Influencing factors of methodological quality were statistically analyzed using RevMan 5.3 software. The included systematic reviews/metaanalysis must include the following characteristics: (1) methods using systematic evaluation/meta-analysis, (2) probiotic intervention, and (3) language limitation to Chinese and English.

Results

The AMSTAR score was 5–9 (7.42 ± 1.22), and the quality is above average. The factors affecting the methodological quality are the number of authors and whether they cooperate with the institution.

Conclusions

Studies have shown that current systematic reviews/meta-analysis of the effectiveness of probiotics on IBS does not fully comply with methodological quality standards, and therefore the methodological quality of research in this area needs to be strengthened. To better clarify how probiotics affect IBS, future systematic reviews and meta-analyses should not only follow methodological quality standards but also include more effective outcome measures, and they should focus more on the discussion of research results. We look forward to the development of higher-quality randomized controlled trials in the future.
Shadow Memorial Diplomacy: The Ronald Reagan Centennial Year in Central and Eastern Europe
Authors: Tóth György
Published: July 2019

This article examines the use of the memorialization of Reagan in transatlantic relations – specifically in the commemorations of the Ronald Reagan Centennial Year in 2011 in Central and Eastern Europe. Extrapolating from the case of Hungary, the article argues that because of the contemporary political status of its drivers and its oblique message, the Reagan Centennial’s campaign in Central Europe can be called “shadow” memorial diplomacy, which in 2011 used the former president’s memory to articulate and strengthen a model of U.S. leadership and foreign policy parallel to and ready to replace those of the then Obama administration. This study can serve as an international extension of previous scholarship on the politics of the memory of Ronald Reagan within the United States, as well as a case study of the use of memory in international relations.
CT in the diagnosis of nontraumatic acute abdominal pain: clinical cases
Authors: Arablinskii A. V. , Magdebura Yu. A.
Published: July 2019

Acute abdominal pain (AAP) is a clinical symptom complex that develops with injuries and acute surgical diseases of the abdominal organs. This condition is one of the most frequent causes of admission of patients to the hospital through the ambulance. Patients with AAP consist of a large and heterogeneous group at the same time due to the etiology and many variations of the clinical picture of this condition. The article presents the results of CT scan of the abdominal cavity and small pelvis in 5 patients with AAP admitted to the S.P. Botkin Moscow City Clinical Hospital emergency department during 2017–2018, without indication of the possible traumatic nature of the pathology. All patients underwent a primary surgeon examination and first-line medical imaging methods such as plane radiography and ultrasound. The selection criterion for inclusion in the search was the need for CT due to the lack of data obtained for diagnosis. Subsequently, the findings of the CT scan were compared with the final diagnosis in the electronic medical file of the patient concerned, to assess the contribution of CT data to the diagnostic process. In a group of 5 patients included in the study, the results of CT were the decisive step in the diagnostic process in 100% of cases. Therefore, the study emphasizes the importance of using CT in patients with AAP. Using this method allows you to complete a diagnostic search as soon as possible from the time the patient enters the hospital, to begin timely treatment.
The Mondrian Cake: may Intellectual Property protect signature food?
Authors: Rocha Maria Victória
Published: July 2019

Taking the example of the Mondrian Cake, in this article we distinguish recipes from presentation of signature dishes, as well as cookbooks, menus and restaurants and aim to know what can be protected by Intellectual Property (e.g. copyright, patents, designs, trademarks, trade dress, trade secrets, general rules against unfair competition or even nondisclosure agreements and fiduciary duties). Regarding copyright, we emphasise the difference between USA and Continental Copyright approach. For situations where some kind of Intellectual Property protection is possible, we question enforcement and if all type of protection is desirable. What we conclude about food applies to beverages.
Difusi inovasi cerita prosa rakyat dalam aplikasi audiobuku
Authors: Rukmana Evi Nursanti , Yusup Pawit M. , Erwina Wina
Published: July 2019

The folklore is a story in all-region as documentation of culture in the community. In the information community, people to need activities in the reading with easy and fast to use. AudioBuku is an application in handphone (HP) that has a collection of folklore at Indonesia. The purpose this research is to know diffusion of innovation the folklore in AudioBuku, consist of a process of innovation, a process of diffusion, and a process of adoption. The method this research used qualitative methods approach with case study method. The result this research is in the innovation process, the feature of AudioBuku can to direct the children’s to listen to audio the folklore. The folklore collection is free and unfree to access. In process of diffusion, AudioBuku media on HP can be access by the children and the parents. In the adoption process, more of the children and the parents as a sustainable adoption and adoption. They can to use AudioBuku continuously or an only certain time. AudioBuku has serve facilitate education consist of audio media to use in reading activities.
Salinity and sodicity influence on Taramira (Eruca sativa), A medicinal crop
Authors: Ullah Muhammad Arshad , Rasheed Muhammad , Mahmood Imdad Ali
Published: July 2019

Seeds of Taramira (Eruca sativa) as medicinal plant were sown in a pot study under various salinity cum sodicity levels. Out of different levels tested, 4 dSm-1+ 13.5 (mmol L-1)1/2 treatment got maximum biomass yield (34 gpot-1). It was declined due to salinity increase. At 10 dSm-1 + 30 (mmol L-1)1/2 minimum biomass yield (22.33 gpot-1) was gotten. Results also indicated decrease (%) of biomass yield over lowest level of salinity cum sodicity. Least reduction % over control (15.73) was attained by 5 dSm-1 + 25 (mmol L-1)1/2 treatment showing better tolerance. Growth least reduction % over control was ranging from 15.73% to 34.32% due to toxic salts. This variation was linked with toxic influence of salts on plant growth. At the nutshell, Taramaria (Eruca sativa) was produced maximum growth under 4 dSm-1+ 13.5 (mmol L-1)1/2.
Prediction of asphaltene precipitation upon injection of various gases at near-wellbore conditions: A simulation study using PC-SAFT EoS
Authors: Mahmoudvand Saba , Shahsavani Behnam , Parsaei Rafat , Malayeri Mohammad Reza
Published: July 2019

The depletion of oil reservoirs and increased global oil demand have given impetus to employ various secondary and tertiary oil recovery methods. Gas injection is widely used in both secondary and tertiary modes, though the major problem associated with this process is the precipitation and deposition of asphaltene, particularly at near-wellbore conditions. In-depth knowledge of asphaltene phase behavior is therefore essential for the prediction of asphaltene precipitation. Previous studies reported the impact of gas injection on asphaltene phase behavior, but the knowledge of precipitation of asphaltene as a function of different mole fractions of injected gas is also imperative. In this study, the thermodynamic model of PC-SAFT EoS is used to discern the phase equilibrium of asphaltene by analyzing the asphaltene drop-out curve during gas injection. Asphaltene drop-out curves of two different live oil samples are analyzed by injecting CO2, CH4, and N2 gases at different mole percentages and temperatures. The results revealed that PC-SAFT EoS can serve as a reliable tool for estimating bubble pressure and asphaltene onset pressure for a wide range of temperatures, pressures, and compositions. The simulation results for the injection of CO2, CH4, and N2 also showed that CO2 gas gives minimum asphaltene precipitation. It reduces the size of the drop-out curve or moves it toward higher pressures. CH4 and N2 expand the drop-out curve by raising the upper onset point. CH4 increases the maximum point of the drop-out curve for two types of oil studied (A and B) at two different temperatures. N2 raises the maximum point of oil type “A” by approximately 57% at 395 K, while it has no effect on the maximum point of oil type “B”. In addition, reducing the temperature resulted in either decrease or increase of asphaltene solubility, demonstrating that the impact of temperature on asphaltene precipitation is closely related to the composition of the crude.
Potentials of brentuximab vedotin in the treatment of relapse/refractory cutaneous T-cell lymphomas: literature review and authors’ observation
Authors: Gorenkova L. G. , Kravchenko S. K. , Belousova I. E.
Published: July 2019

Primary cutaneous T-cell lymphomas encompass a heterogeneous group of T-cell lymphoproliferative disorders developing primarily in the skin and characterized by a number of specific diagnostic, clinical, and therapeutic features. Mycosis fungoides accounts for more than half of all cutaneous lymphoma cases, while CD30+ lymphoproliferative diseases of the skin (primary cutaneous anaplastic large-cell lymphoma and lymphomatoid papulosis) constitute one-fourth of them and the remaining cases are rare tumour types, including primary cutaneous peripheral T-cell lymphoma, unspecified/not otherwise specified.

Activation antigen СD30 is a cell membrane glycoprotein of the tumour necrosis factor family. More than 75 % of primary cutaneous CD30-positive lymphoma cells express CD30; it may be detected in other diseases as well, but to a lesser extent.

Most patients with cutaneous CD30+ lymphoproliferative diseases have indolent disease and a favourable prognosis; resistant disease is observed in approximately 30 % of sufferers, and fatal outcomes occur in 8 % of cases [1].

Systemic immunomodulatory therapy or chemotherapy is often used in advanced disease. Monoclonal antibodies were recently introduced into clinical practice for the treatment of cutaneous lymphomas. One of these agents is brentuximab vedotin, a CD30-monoclonal antibody conjugated to monomethyl auristatin E.

We present two case reports: one of frequently recurring lymphomatoid papulosis and the other of refractory primary cutaneous peripheral T-cell lymphoma, unspecified/not otherwise specified. Targeted therapy with brentuximab vedotin, either alone or in combination with chemotherapy, resulted in a sustained, long-lasting remission in both cases.
Angina bullosa hemorrhagica
Authors: Borovikov Yu. E. , Bukin Yu. K.
Published: July 2019

Angina bullosa hemorrhagica (ABH) is a term used to describe acute, subepithelial oral mucosal blisters filled with blood without any systemic disorder or hemostatic defect. The diagnosis of ABH is largely clinical, and includes elimination of other diseases at histology. We present a 24-year-old patient suffering from ABH with some clinical peculiarities. Recognition of ABH is of great importance to dermatologists, to avoid misdiagnosis.
Phosphodiesterase-4 inhibitor in the treatment of psoriasis and psoriatic arthritis
Authors: Olisova O. Yu. , Svistunova D. A. , Chernyavskaya L. M. , Anpilogova E. M.
Published: July 2019

Treatment of psoriasis and psoriatic arthritis, especially moderate and severe, represents difficulties. Recently, various methods of molecular medicine have been actively developed, however, targeted therapy deserves special attention, which consists of chemical agents that have specific target as a specific protein or enzyme. Targeted therapy is a promising direction in many branches of medicine, especially in dermatology.

Despite the wide range of biological products, their use may be accompanied by an increased risk of infectious processes and malignant neoplasms, which makes the search for a new pharmacological solution in targeted therapy even more relevant.

This review presents the possibilities and prospects for the therapeutic use of the phosphodiesterase-4 inhibitor from the group of small molecules — apremilast, primarily in the treatment of psoriasis and psoriatic arthritis.
Clinical and pathological changes in the skin with granuloma annulare
Authors: Kharchilava M. G. , Khairutdinov V. R. , Belousova I. E. , Samtsov A. V.
Published: July 2019

Granuloma annulare (GA) is a dermatosis of unknown etiology, which has distinctive clinical and histological features. In this article, we present current information about the etiology, pathogenesis, clinical picture and pathomorphological signs of GA, as well as conduct differential diagnosis of GA with diseases that have a similar clinical and histological picture.
Structurally Diverse Covalent Triazine-based Framework Materials for Photocatalytic Hydrogen Evolution from Water
Authors: Meier Christian B. , Clowes Rob , Berardo Enrico , Jelfs Kim , Zwijnenburg Martijn , Sprick Seb , Cooper Andrew I.
Published: July 2019

A structurally diverse family of 39 covalent triazine-based framework materials (CTFs) is synthesized by Suzuki-Miyaura polycondensation and tested as hydrogen evolution photocatalysts using a high-throughput workflow. The two best-performing CTFs are based on benzonitrile and dibenzo[b,d]thiophene sulfone linkers, respectively, with catalytic activities that are among the highest for this material class. The activities of the different CTFs are rationalized in terms of four variables: the predicted electron affinity, the predicted ionization potential, the optical gap, and the dispersibility of the CTFs particles in solution, as measured by optical transmittance. The electron affinity and dispersibility in solution are the best predictors of photocatalytic hydrogen evolution activity.
JAVASCRIPT ASYNCHRONOUS PROGRAMMING
Authors: Luong Tran Thanh , Canh Le My
Published: July 2019

JavaScript has become more and more popular in recent years because its wealthy features as being dynamic, interpreted and object-oriented with first-class functions. Furthermore, JavaScript is designed with event-driven and I/O non-blocking model that boosts the performance of overall application especially in the case of Node.js. To take advantage of these characteristics, many design patterns that implement asynchronous programming for JavaScript were proposed. However, choosing a right pattern and implementing a good asynchronous source code is a challenge and thus easily lead into less robust application and low quality source code. Extended from our previous works on exception handling code smells in JavaScript and exception handling code smells in JavaScript asynchronous programming with promise, this research aims at studying the impact of three JavaScript asynchronous programming patterns on quality of source code and application.
粉砂地质下超深基坑拉森钢板桩应用分析
Authors: 梅 云弟
Published: July 2019

在高铁线路施工中，存在大量深度大于 10m 的超深基坑，其中尤以无粘聚力、透水性强及地质条件复杂的粉砂层为主要土层的深基坑拉森钢板桩施工难度大、危险性高。通过本文的详细研究，以期为今后的类似基坑支护设计和施工提供参考。
广东韶关大宝山矿稀土元素特征初探
Authors: 魏 振伟
Published: July 2019

稀土元素在化学性质上的相似性和系统差异，经常作为一个整体出现在矿物和岩石中，可以用于涉及矿物或矿物 - 熔体之间微量元素分异的地球化学过程示踪，用来解释热液体系中的水 - 岩反应机理和金属矿床的成因等方面。本文通过对大宝山钼多金属矿床岩矿石样品稀土元素组成的研究，利用稀土元素示踪成矿过程的一个重要途径分析对比原岩和不同成矿蚀变阶段产物中 REE 的组成与分布，从中恢复成矿流体的性质和演化，总结其稀土元素的分配特征。
计量检定机构信息化建设路径探究
Authors: 任 万杰
Published: July 2019

信息化时代的到来，各行各业在现代化发展过程中，对于信息化技术的使用程度都大大提高。计量检定机构也是如此，为了更好适应企业快速发展，将信息技术大量应用到实际检定工作中，进一步提高工作效率和实现现代化。所以在本文中将深刻揭示信息化技术在计量检定机构实际工作过程中的功能以及应用现状，并对计量检定机构应用信息化技术的优化进行论述。
Tree-rings in Mediterranean pines – can we ascribe them to calendar years?
Authors: Balzano Angela , De Micco Veronica , Merela Maks , Čufar Katarina
Published: July 2019

A tree ring is defined as a band of xylem-cell layers produced in one year. In Mediterranean trees cambium often produces several bands of alternating early- and latewood during one calendar year, resulting in Intra-Annual Density Fluctuations (IADFs). We present some characteristics of growth layers in Pinus pinea (stone pine) growing on Vesuvius Mountain (near Naples, Italy). The trees showed uninterrupted wood production from January 2015 till the end of January 2016. The ring formed in this period contained five different layers of wood types. Therefore, the wood formed between January and March 2015 would be falsely ascribed to latewood of the tree ring 2014, and the wood formed between March 2015 and the end of January 2016 would be classified as tree ring 2015. We also showed differences in cambium activity in late autumn between years: in November 2015 and 2018 the cambium was still active and not active anymore, respectively. Furthermore, we present the structure of the wood formed in the year 2017 affected by a wildfire in July. Such cases where the growth layer cannot be exactly ascribed to a calendar year should be considered in dendrochronological studies of Pinus pinea and other Mediterranean species.
The influence of thermal modification on the machining properties of beech wood
Authors: Merhar Miran , Šega Bogdan , Gornik Bučar Dominika
Published: July 2019

The work analyses the influence of thermal modification on the machining properties of beech wood, where the quality of the surface is evaluated after the operation of planing, routing and turning of unmodified and modified beech. After machining, the surface is visually assessed with grades from 1 to 5, with respect to defects of raised, fuzzy and torn grain. As a result an average grade for each type of operation is given, as well as the percentage of each grade. It has been found out that the average grades of thermally modified beech wood in planing were better compared to unmodified beech, but ANOVA analysis did not confirm differences between them. There was also no difference in routing, while in turning the influence of modification was significant, since the surface quality of the thermally modified beech was significantly better compared to that of unmodified beech. From the analysis it can be concluded that thermal modification has a positive effect on the quality of the machined surface.
O Estado plurinacional e o sistema plurijurídico: um avanço no desenvolvimento da sociedade Latinoamericana
Authors: De Miranda José Alberto Antunes
Published: July 2019

O cenário constitucional latino-americano, demonstrou ao mundo europeu e norte-americano, a possibilidade de alcançar uma nova racionalidade social e política, especialmente no que se refere às decisões do Estado. A democracia do estado plurinacional vai além dos mecanismos representativos majoritários propiciando espaço crescente para os instrumentos institucionalizados de construção de consensos. O objetivo desse artigo é apresentar a evolução da visão de modernidade, destacada pela construção social do Estado, onde as constituições e os movimentos de mudança emergem em um cenário moderno na busca pela equiparação do diverso no cenário latino americano por meio do Estado plurinacional e do sistema plurijurídico. A metodologia utilizada é a fenomenológica, constatando os fatos para, a partir dos mesmos, tecer possibilidades explicativas com potencial de fornecer um quadro compreensivo da realidade que se tenta abranger. Conclui-se que existem muitas melhorias e avanços a serem alcançados, partindo de uma luta já iniciada pelo descolonialismo e intitulada como um avanço social democrático. Interesses políticos, em muitos momentos da história da América Latina, se sobrepuseram aos interesses coletivos, em especial a população indígena originária campesina, mas que devem ser superados para que o teor Pluralista tenha plenitude em sua intenção de abrangência coletiva.
Rancang Bangun Alat Prototipe Pendeteksi Kebakaran dengan Android Melalui Internet of Things
Authors: Kusnandar Kusnandar , Dharmi Ni Ketut Hariyawati , Pratika Dwi Ajeng
Published: July 2019

Akhir-akhir ini sering terjadi kebakaran yang disebabkan oleh beberapa faktor termasuk faktor kelalaian manusia. Proses datangnya kebakaran selalu tanpa dapat diprediksi terlebih dahulu. Umumnya kebakaran diketahui apabila keadaan api sudah mulai membesar atau asap sudah mengepul keluar dari gedung itu. Pada penelitian ini dilakukan perancangan alat, mencari komponen serta mendesain pendeteksi kebakaran dari komponen-komponen yang ada sehingga alat akan bekerja lebih maksimal. Pada tahap ini juga melakukan pembuatan algoritma dan juga software. Hasil penelitian menunjukkan bahwa prototipe sistem pendeteksi kebakaran yang dirancang dapat mendeteksi kebakaran berdasarkan informasi dari sensor api  dan gas, dan mengaktifkan buzzer sebagai indikatornya yang akan berbunyi.
STUDI KELAYAKAN BISNIS PRODUKSI & PEMASARAN CAKE DI KOTA BANDUNG (KASUS DI CV. YEYE GROUP)
Authors: Nasution Andri Rachmat Kumalasian , Nurhadi Nurhadi
Published: July 2019

CV. Yeye group merupakan salah satu perusahaan yang bergerak di bidang usaha kuliner produksi dan penjualan makanan cepat saji dengan membuka beberapa usaha yang antara lain mie ramen, batagor, baso, ayam bakar, dan lain-lain. Untuk mengembangkan usaha kulinernya maka perusahaan berencana untuk mengalokasikan modal yang dimilikinya untuk membuka usaha baru di bidang usaha makanan dengan jenis yang berbeda dari jenis usaha sebelumnya dengan tujuan untuk menjama konsumen yang lebih luas dan mendapatkan keuntungan yang lebih besar. Usaha baru yang di rencanakan oleh perusahaan adalah membuat pabrik dan memasarkan kue. Untuk mengetahui besar kebutuhan modal usaha yang diperlukan untuk mendirikan bisnis, mengetahui besar potensi pasar yang dapat dikuasai dan mengetahui tingkat kelayakan usaha apabila direalisasikan maka perlu dilakukan studi kelayakan bisnis berdasarkan aspek pasar & pemasaran, aspek teknis & tekonologi, aspek organisasi & manajemen, dan aspek keuangan. Alat analisis yang digunakan dalam penelitian ini adalah analisis usaha berdasarkan nilai PI, PP, ROI, NPV,IRR, dan analisis risiko. Hasil analisis kelayakan menunjukan usaha ini layak untuk direalisasikan, hal tersebut salah satunya ditunjukan dengan analisa aspek keuangan yang menghasilkan nilai PI yang lebih dari 1, nilai PP yang kurang dari 3 tahun.
Haurdunaldiko kutsadura atmosferikoaren eta jaioberriaren tiroxina-mailaren arteko erlazioa, INMA-Gipuzkoa
Authors: Txintxurreta Arantxa , Lertxundi Aitana , Irizar Amaia , Martínez Maria Dolores , Ibarlucea Jesús
Published: July 2019

Kutsadura atmosferikoak tiroidean eragiten du, azken urteotako ikerketak agerian uzten ari direnez. Lan honetan aztertu nahi izan dugu jaioberriaren orpoko odolean neurtutako T4 hormona tiroideo totalean zer eragin ote duten jaio aurretiko 2.5 µm-ko edo gutxiagoko diametroko partikulekiko (PM2.5) zein aireko nitrogeno dioxidoarekiko (NO2) esposizioek. Aztertutako lagina Gipuzkoako INMA ikerketatik atera dugu. Elkarrekintza estimatzeko eredu lineal multibarianteak erabili ditugu. Zenbat eta handiagoa PM2.5 eta NO2-arekiko esposizioa, hainbat eta T4-maila altuagoa; emaitza estatistikoki esanguratsua (β= 0,15, %95KT9: 0,02; 0,27, p=0,019) izan da partikulen kasuan eta esangura estatistikotik gertu (β= 0,04, %95KT=:-0,01; 0,09, p=0,099) egon da nitrogeno dioxidoaren kasuan.
The Uses of PQ4R and SSR Strategies in EFL Reading Classroom
Authors: Agustiani Merie
Published: July 2019

Abstract. This paper reports an experimental study which investigated the use of Preview, Question,Read, Reflect, Recite, Review (PQ4R) strategy and Sustained Silent Reading (SSR) strategy to the eleventh grade students of SMA Negeri 1 OKU. Two classes consisted of 30 students in each class were choosen randomly and assigned as PQ4R group and SSR group. Reading comprehension test that consisted of 35 multiple choice questions was used to collect the data. Meanwhle, t-test was used to find out the significant results of the two strategies and stepwise regression was used to find out what aspect of reading comprehension that mostly contributed on  students’ achievement. Findings of this study showed that there were significant different achievement of the students after the interventions using PQ4R and SSR strategies which means that the two strategies were proved significantly effective to improve the students’ reading comprehension achievement, but the independent t-test result showed that SSR strategy gave more significant improvement toward students’ reading comprehension achievement
Writing Caption on Instagram as Media for Student’s Motivation and Writing Skill Improvement
Authors: Gunantar Devy Angga , Transinata Tatas
Published: July 2019

This study aims to describe the use of caption on Instagram to improve students' writing skill and motivation. This research is a classroom action research (CAR). The research subject was class VIII SMP N 3 Mranggen Demak with a total of 31 students. This study was conducted in two cycles. The Pre-Test was held before the first cycle was implemented. The researcher used descriptive qualitative method to describe the use of caption on Instagram for student’s motivation and writing skill improvement. The results showed that the use of caption on Instagram can improve student’s motivation and writing skill. In the first cicle of the pre-tests that have been conducted, it was known that only 2 students (6,5%) got scores between 60 - 64. While 28 students (93%) got scores below 60. The number of students who scored above 60 increased in in the post-test I, there were 19 students with an average score of 69,5. The score of students rose significantly in the post-test II, it was found that there was a satisfactory increase in scores with the highest score of 87 and the lowest score of 66 (1 student)
Evaluación de la calidad de la medición de carbono total en suelo mediante ensayo de intercomparación.
Authors: Guerrero Peña Armando , Jarquín Sánchez Aarón , Etchevers Barra Jorge D. , González Acuña Irma J. , Hernández Nataren Lorena Del Carmen , Cueto Wong José A. , Báez Pérez Aurelio , Hidalgo Moreno Claudia I. , López Anaya Miguel A. , Martínez Vargas Margarita
Published: July 2019

The Mexican regulation NMX-EC-17025-IMNC-2006, establishes that laboratories must have quality control procedures to monitor the validity of tests and calibrations, such monitoring must be planned and reviewed with: a) the regular use of certif ied reference materials or internal quality control of secondary references; b) participation in inter-laboratory comparisons or a prof iciency testing program; c) the repetition of tests or calibrations using the same method or different methods; d) the repetition of the test or the calibration of determined objects; e) the correlation of results for different characteristics of a reference material certif ied by MRC. The quality evaluation of results from the eight laboratories of the Laboratory Network for Analysis, Use, Conservation and Management of Soil (REDLABS) included the elements of sections a), b), c), and d) in order to verify the hypothesis that laboratories emit repeatable, reproducible and unbiased results. In our study, elemental analyzers of different brands were used to measure the total carbon of soil. A certif ied reference material was included in the Inter-comparison Practice. Repeatability and reproducibility of the carbon analyzes were evaluated with samples from the inter-comparison practice; the precision of analyzes from each laboratory was qualif ied with MRC. The results obtained indicate that the laboratories show repeatability in their analyzes with no statistical differences, i.e. reproducibility is detected by inter-comparison. The data issued by the laboratories were unbiased according to their evaluation with certif ied reference material.
Caracterización física y química de biochar de lodos residuales.
Authors: Velázquez Machuca Martha Alicia , Equihua Soriano Juan Rosario , Venegas González José , Montañez Soto José Luis , Pimentel Equihua José Luis , Muñoz Navia Milton
Published: July 2019

Pyrolysis treatment of sewage sludge to generate biochar is one of the current alternatives for environmental management of this waste. The treatment transforms sewage sludge into biochar, conserves some of the characteristics that give it an important agronomic value and reduces its pathogen content. The objective of this study was to analyze the potential use of the sewage sludge biochar obtained from the wastewater treatment plant (WWTP) of Morelia, Michoacán, México, as an agricultural soil improver considering the physical-chemical properties of the material and its content of nutrients and heavy metals as indicators. The sewage sludge was subjected to pyrolysis (SSB) in an experimental scale reactor that uses solar energy, with six residence times and temperature of 280 to 355 oC. The parameters analyzed were: pH EC, OM, Cu, Mn, Zn, Fe available (DTPA and EDTA), elemental composition (C, N, O, Ca, Mg, Na, K, P, S, Cl, Si, Al, Fe, Mn, Cu, Zn, Ti, Ni, Cr, Cd and Pb). The EC of the SSB obtained was from 592 to 5240 μS cm‑1, pH = 6.33 to 7.02, OM = 3.8 to 5.6%, high contents of C, N, P (31 to 38%, 6.5 to 7.7% and 37.7 to 48.8 g kg‑1, respectively), low Na/Ca ratio and a low content of total and available heavy metals. The properties of the SSB obtained indicate that it can be used as an agricultural soil improver since it is a material with high nutrient content and low environmental risk in terms of its low heavy metal content. These results should be complemented with studies on the response of plants to BLR, monitoring of physical-chemical conditions and analysis of organic contaminants in soil and water where this material is applied.
Evaluación de la estabilidad de taludes en cárcavas, Huasca de Ocampo, Hidalgo, México.
Authors: Hernández Sánchez Jazmin Maria de los Dolores , Fernández Reynoso Demetrio S. , Martínez Menez Mario R. , Figueroa Sandoval Benjamín , Rubio Granados Erasmo , García Rodríguez José Luis
Published: July 2019

In Santo Domingo, Huasca de Ocampo, Hidalgo, changes in the use of soil, the topographic and geomorphological conditions and the increase of runoffs, promote the formation of gullies in agricultural areas, causing the loss of soil fertility and a reduction of agricultural land. The objective of our research was to identify the main topographic features and physical/mechanical properties of the soil that cause a sidewall retreat of gullies (AV); determination was performed through principal component analysis (PCA) and multiple linear regression (MLR). The AV varied from 0.04 to 0.17 m yr‑1 with a mean value of 0.092 m yr-1. The most important variables in the PCA were: height, slope, orientation, vertical and horizontal curvature, transversal slope, ridge thickness, bulk density (0 to 5 and 5 to 10 cm), penetration resistance (2.5, 5 and 10 cm), hydraulic conductivity, shrinkage index, plasticity index, 0.25, 0.15 and 0.075 mm particles, cohesion and soil erodibility factor. The best linear regression explanatory model presented a f it value of 84.02% using four variables (particles of 0.15 and 0.075 mm, slope and ridge thickness). The AV is influenced by the presence of silt and clay in the regolith and soil surface (ridge), which are vulnerable to wetting and drying processes that boost the formation of cracks and disaggregation of the components of ridge and slope, reducing the soil’s resistance to erosion and causing headward erosion and instability in the gully slopes.