bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing a digital intervention for cancer survivors: an evidence-, theory- and person-based approach
Authors: Bradbury Katherine , Steele Mary , Corbett Teresa , Geraghty Adam W. A. , Krusche Adele , Heber Elena , Easton Steph , Cheetham-Blake Tara , Slodkowska-Barabasz Joanna , Müller Andre Matthias , Smith Kirsten , Wilde Laura J. , Payne Liz , Singh Karmpaul , Bacon Roger , Burford Tamsin , Summers Kevin , Turner Lesley , Richardson Alison , Watson Eila , Foster Claire , Little Paul , Yardley Lucy
Published: September 2019

This paper illustrates a rigorous approach to developing digital interventions using an evidence-, theory- and person-based approach. Intervention planning included a rapid scoping review that identified cancer survivors’ needs, including barriers and facilitators to intervention success. Review evidence (N = 49 papers) informed the intervention’s Guiding Principles, theory-based behavioural analysis and logic model. The intervention was optimised based on feedback on a prototype intervention through interviews (N = 96) with cancer survivors and focus groups with NHS staff and cancer charity workers (N = 31). Interviews with cancer survivors highlighted barriers to engagement, such as concerns about physical activity worsening fatigue. Focus groups highlighted concerns about support appointment length and how to support distressed participants. Feedback informed intervention modifications, to maximise acceptability, feasibility and likelihood of behaviour change. Our systematic method for understanding user views enabled us to anticipate and address important barriers to engagement. This methodology may be useful to others developing digital interventions.
Regional heterogeneity impacts gene expression in the subarctic zooplankter Neocalanus flemingeri in the northern Gulf of Alaska
Authors: Roncalli Vittoria , Cieslak Matthew C. , Germano Martina , Hopcroft Russell R. , Lenz Petra H.
Published: September 2019

Marine pelagic species are being increasingly challenged by environmental change. Their ability to persist will depend on their capacity for physiological acclimatization. Little is known about limits of physiological plasticity in key species at the base of the food web. Here we investigate the capacity for acclimatization in the copepod Neocalanus flemingeri, which inhabits the Gulf of Alaska, a heterogeneous and highly seasonal environment. RNA-Seq analysis of field-collected pre-adults identified large regional differences in expression of genes involved in metabolic and developmental processes and response to stressors. We found that lipid synthesis genes were up-regulated in individuals from Prince William Sound and down-regulated in the Gulf of Alaska. Up-regulation of lipid catabolic genes in offshore individuals suggests they are experiencing nutritional deficits. The expression differences demonstrate physiological plasticity in response to a steep gradient in food availability. Our transcriptional analysis reveals mechanisms of acclimatization that likely contribute to the observed resilience of this population.
Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice
Authors: Miyazaki Tomoaki , Gharib Sina A. , Hsu Yun-Wei A. , Xu Katherine , Khodakivskyi Pavlo , Kobayashi Akio , Paragas Jason , Klose Alexander D. , Francis Kevin P. , Dubikovskaya Elena , Page-McCaw Patrick S. , Barasch Jonathan , Paragas Neal
Published: September 2019

The kidney’s inherent complexity has made identifying cell-specific pathways challenging, particularly when temporally associating them with the dynamic pathophysiology of acute kidney injury (AKI). Here, we combine renal cell-specific luciferase reporter mice using a chemoselective luciferin to guide the acquisition of cell-specific transcriptional changes in C57BL/6 background mice. Hydrogen peroxide generation, a common mechanism of tissue damage, was tracked using a peroxy-caged-luciferin to identify optimum time points for immunoprecipitation of labeled ribosomes for RNA-sequencing. Together, these tools revealed a profound impact of AKI on mitochondrial pathways in the collecting duct. In fact, targeting the mitochondria with an antioxidant, ameliorated not only hydrogen peroxide generation, but also significantly reduced oxidative stress and the expression of the AKI biomarker, LCN2. This integrative approach of coupling physiological imaging with transcriptomics and drug testing revealed how the collecting duct responds to AKI and opens new venues for cell-specific predictive monitoring and treatment.
Alpha rhythm collapse predicts iso-electric suppressions during anesthesia
Authors: Cartailler Jérôme , Parutto Pierre , Touchard Cyril , Vallée Fabrice , Holcman David
Published: September 2019

Could an overly deep sedation be anticipated from ElectroEncephaloGram (EEG) patterns? We report here motifs hidden in the EEG signal that predict the appearance of Iso-Electric Suppressions (IES), observed during epileptic encephalopathies, drug intoxications, comatose, brain death or during anesthetic over-dosage that are considered to be detrimental. To show that IES occurrences can be predicted from EEG traces dynamics, we focus on transient suppression of the alpha rhythm (8–14 Hz) recorded for 80 patients, that had a Propofol target controlled infusion of 5 μg/ml during a general anesthesia. We found that the first time of appearance as well as changes in duration of these Alpha-Suppressions (αS) are two parameters that anticipate the appearance of IES. Using machine learning, we predicted IES appearance from the first 10 min of EEG (AUC of 0.93). To conclude, transient motifs in the alpha rhythm predict IES during anesthesia and can be used to identify patients, with higher risks of post-operative complications.
Electrostatic force driven helium insertion into ammonia and water crystals under pressure
Authors: Bai Yihong , Liu Zhen , Botana Jorge , Yan Dadong , Lin Hai-Qing , Sun Jian , Pickard Chris J. , Needs Richard J. , Miao Mao-Sheng
Published: September 2019

Helium, ammonia and ice are among the major components of giant gas planets, and predictions of their chemical structures are therefore crucial in predicting planetary dynamics. Here we demonstrate a strong driving force originating from the alternation of the electrostatic interactions for helium to react with crystals of polar molecules such as ammonia and ice. We show that ammonia and helium can form thermodynamically stable compounds above 45 GPa, while ice and helium can form thermodynamically stable compounds above 300 GPa. The changes in the electrostatic interactions provide the driving force for helium insertion under high pressure, but the mechanism is very different to those that occur in ammonia and ice. This work extends the reactivity of helium into new types of compounds and demonstrates the richness of the chemistry of this most stable element in the periodic table.
Iridium-catalyzed Markovnikov hydrosilylation of terminal alkynes achieved by using a trimethylsilyl-protected trihydroxysilane
Authors: Xie Xingze , Zhang Xueyan , Gao Weiwei , Meng Congcong , Wang Xiaojun , Ding Shengtao
Published: September 2019

Developing efficient strategies for Markovnikov hydrosilylation of alkynes is still an important goal. The steric and electronic properties of hydrosilanes are key factors in controlling selectivity in these reactions. Here by using a trimethylsilyl-protected trihydroxysilane, we report a mild, efficient strategy for Markovnikov hydrosilylation of terminal alkynes with the simple catalyst [Ir(μ-Cl)(cod)]2. A variety of terminal alkynes are hydrosilylated efficiently with outstanding α-regioselectivity. This protocol is successfully utilized in the late-stage hydrosilylation of derivatives of various bio-relevant molecules. The residual silyl group, -Si(OSiMe3)3, can participate in organic transformations directly, or be converted into other useful silyl groups.
Quantum dot-based Baijiu fluorescent identification sensor array jointly verified by multivariate analysis and radial basis function neural network
Authors: Yang Ping , Li Jiawei , Li Pan , Hou Changjun , Huo Danqun , Yang Yixia , Zhang Suyi , Shen Caihong
Published: September 2019

A quantum dot array, prepared using a novel method, was used for cross-reflection Baijiu identification.
Photothermal-modulated reversible volume transition of wireless hydrogels embedded with redox-responsive carbon dots
Authors: Phuong Pham Thi My , Jhon Heesauk , In Insik , Park Sung Young
Published: September 2019

The reversible volume transition of redox-responsive hydrogels by NIR has attracted attention as novel therapy for tracking and treating cancerviastimuli-responsive fluorescence on/off with controllable volume transitionviawireless system.
Peptide decorated glycolipid nanomicelles for drug delivery across the blood–brain barrier (BBB)
Authors: Meenu Vasudevan S. , Ashwanikumar N. , Vinod Kumar G. S.
Published: September 2019

Schematic summary of the development of peptide decorated glycolipid nanomicelles for brain delivery by crossing Blood Brain Barrier (BBB).
Simple and robust polymer-based sensor for rapid cancer detection using serum
Authors: Le Ngoc D. B. , Singla Arvind K. , Geng Yingying , Han Jinsong , Seehafer Kai , Prakash Gyan , Moyano Daniel F. , Downey Charlene M. , Monument Michael J. , Itani Doha , Bunz Uwe H. F. , Jirik Frank R. , Rotello Vincent M.
Published: September 2019

Rapid detection of cancer using a simple FRET-based polymer sensor.
The base-catalysed Tamura cycloaddition reaction: calculation, mechanism, isolation of intermediates and asymmetric catalysis
Authors: Lockett-Walters Bruce , Trujillo Cristina , Twamley Brendan , Connon Stephen
Published: September 2019

A combination of experimental and computational techniques has shown that the mechanism of the base-catalysed Tamura cycloaddition is not a concerted Diels–Alder process.
Aluminum substitution for vanadium in the Na3V2(PO4)2F3 and Na3V2(PO4)2FO2 type materials
Authors: Olchowka Jacob , Nguyen Long H. B. , Broux Thibault , Sanz Camacho Paula , Petit Emmanuel , Fauth François , Carlier Dany , Masquelier Christian , Croguennec Laurence
Published: September 2019

Investigation of the effects of Al substitution for V on the structural properties and electrochemical performances for two of the most promising positive electrode materials for Na-ion batteries, Na3V2(PO4)2F3 and Na3V2(PO4)2FO2.
A visible-light photoactivatable di-nuclear PtIV triazolato azido complex
Authors: Yao Kezi , Bertran Arnau , Howarth Alison , Goicoechea Jose M. , Hare Samuel M. , Rees Nicholas H. , Foroozandeh Mohammadali , Bowen Alice M. , Farrer Nicola J.
Published: September 2019

A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2).
Single Sb sites for efficient electrochemical CO2 reduction
Authors: Jia Mingwen , Hong Song , Wu Tai-Sing , Li Xin , Soo Yun-Liang , Sun Zhenyu
Published: September 2019

We report the facile synthesis of Sb single atoms for efficient electrocatalytic CO2 reduction to CO.
Photoredox-catalysed formal [3+2] cycloaddition of N-aryl α-amino acids with isoquinoline N-oxides
Authors: Liu Xiangyuan , Yin Yanli , Jiang Zhiyong
Published: September 2019

This work realizes a new synthetic utility of N-aryl α-amino acids as a 1,2-synthon, a new strategy to achieve dearomatization of isoquinolines, and the synthesis of valuable diazabicyclo[3.2.1]octane-based compounds.
Trinuclear Ni(ii) oriented highly dense packing and π-conjugation degree of metal–organic frameworks for efficient water oxidation
Authors: Zhai Zhi-Min , Yang Xiao-Gang , Yang Zhao-Tong , Lu Xiao-Min , Ma Lu-Fang
Published: September 2019

Trinuclear nickel cluster based MOF shows highly denser crystal packing and π-conjugation degree as well as outstanding OER performance with an overpotential of 270 mV at 10 mA cm−2.
Superior adsorptive removal of anionic dyes by MIL-101 analogues: the effect of free carboxylic acid groups in the pore channels
Authors: Yang Ji-Min , Zhang Run-Zhi , Liu Ying-Yan
Published: September 2019

MIL-101-COOH nanoparticles functionalized with free carboxylic acid groups exhibited superior CR, MO, and AC adsorption capacities via their distinctive adsorption mechanisms.
The role of 4-nitrobenzoic acid polymorphs in the crystallization process of organic acid–base multicomponent systems
Authors: Croitor Lilia , Petric Mihaela F. , Szerb Elisabeta I. , Vlase Gabriela , Bourosh Paulina N. , Chumakov Yurii M. , Crisan Manuela E.
Published: September 2019

An investigation of the role of 4-nitrobenzoic acid polymorphs in the crystallization process of dimethylethanolammonium 4-nitrobenzoate from solution and comprehensive characterization of time-dependent changes associated with solid-state transformations are presented.
Water binding to FeIIIhemes studied in a cooled ion trap: characterization of a strong ‘weak’ ligand
Authors: Aarabi Mohammad , Soorkia Satchin , Grégoire Gilles , Broquier Michel , de la Lande Aurélien , Soep Benoît , Omidyan Reza , Shafizadeh Niloufar
Published: September 2019

Characterizing in the gas phase the intense water ligation to ferric heme, dramatically distinct from protonated heme.
A noncovalent interaction insight onto the concerted metallation deprotonation mechanism
Authors: Cornaton Yann , Djukic Jean-Pierre
Published: September 2019

The CMD/AMLA mechanisms of cyclopalladation and the parent fictitious cyclonickelation ofN,N-dimethylbenzylamine have been investigated by joint DFT-D and DLPNO-CCSD(T) methods assisted by QTAIM.
Structure of the aqueous electron
Authors: Herbert John M.
Published: September 2019

A cavity or excluded-volume structure best explains the experimental properties of the aqueous or “hydrated” electron.
Molecular and electronic structure of an azidocobalt(iii) complex derived from X-ray crystallography, linear spectroscopy and quantum chemical calculations
Authors: Domenianni Luis I. , Fligg Reinhold , Schäfermeier Annett , Straub Steffen , Beerhues Julia , Sarkar Biprajit , Vöhringer Peter
Published: September 2019

X-ray diffraction, UV/Vis electronic spectroscopy and Fourier-transform infrared spectroscopy are used with DFT and CAS calculations to explore the molecular and electronic structure of the cationic complex (cyclam)(diazido)cobalt(iii).
Efficient optical limiting of polypyrrole ternary nanohybrids co-functionalized with peripherally substituted porphyrins and axially coordinated metal-porphyrins
Authors: Wang Aijian , Cheng Laixiang , Chen Xiaodong , Li Cheng , Zhang Jing , Zhu Weihua
Published: September 2019

The TPP-PPy-SnTPP ternary nanohybrid exhibits efficient nonlinear optical performances due to its greater effective charge transfer effect, which provides a new avenue for the development of novel optoelectronic devices.
Continuous flow/waste-minimized synthesis of benzoxazoles catalysed by heterogeneous manganese systems
Authors: Ferlin Francesco , van der Hulst Mitchell K. , Santoro Stefano , Lanari Daniela , Vaccaro Luigi
Published: September 2019

Herein, we present our results on the development of a waste minimized protocol for the synthesis of 2-arylbenzoxazoles in continuous flow by combining safe solvent and heterogeneous manganese-based catalyst.
Generating semi-metallic conductivity in polymers by laser-driven nanostructural reorganization
Authors: Yun Changhun , Han Joo Won , Kim Soyeon , Lim Dong Chan , Jung Hyunsu , Lee Seung-Hoon , Jang Jae-Won , Yoo Seunghyup , Leo Karl , Kim Yong Hyun
Published: September 2019

Laser treatment realizes highly conductive PEDOT:PSS transparent films (932 S cm−1), enabling selective doping and facile, fast patterning.
A nanolayer coating on polydimethylsiloxane surfaces enables a mechanistic study of bacterial adhesion influenced by material surface physicochemistry
Authors: Pan Fei , Altenried Stefanie , Liu Mengdi , Hegemann Dirk , Bülbül Ezgi , Moeller Jens , Schmahl Wolfgang W. , Maniura-Weber Katharina , Ren Qun
Published: September 2019

A 2 nm PDMS-like film coating allows identification of the influential factors on bacterial adhesion at the initial colonization stage.
Additional obstacles in carbon nanotube growth by gas-flow directed chemical vapour deposition unveiled through improving growth density
Authors: Tsuji Takashi , Hata Kenji , Futaba Don N. , Sakurai Shunsuke
Published: September 2019

We report growth of ultralong carbon nanotubes by combining a fast-heating chemical vapour deposition process with catalyst support engineering.
Optimizing the molecular structure of 1,1,7,7-tetramethyl julolidine fused furan based chromophores by introducing a heterocycle ring to achieve high electro-optic activity
Authors: Zhang Maolin , Xu Huajun , Fu Mingkai , Yang Min , He Bing , Zhang Xiaoling , Li Zhonghui , Deng Guowei , Bo Shuhui , Liu Jialei
Published: September 2019

Developing new organic chromophores with a large electro-optic coefficient (r33) is highly desirable for fabricating electro-optic (EO) materials.
Theoretical studies on the antioxidant activity of viniferifuran
Authors: Shang Yaxuan , Zhou Huakang , Li Xiangzhou , Zhou Jun , Chen Kai
Published: September 2019

DFT studies reveal the thermodynamics and kinetics of radical scavenging reactions of a resveratrol dimer derivative – viniferifuran.
Phosphorylated micro- vs. nano-cellulose: a comparative study on their surface functionalisation, growth of titanium-oxo-phosphate clusters and removal of chemical pollutants
Authors: Blilid Sara , Katir Nadia , El Haskouri Jamal , Lahcini Mohamed , Royer Sébastien , El Kadib Abdelkrim
Published: September 2019

Phosphorylation imparts cellulose (amorphous or crystalline) with original surface reactivity to bridge metal oxide clusters and to scavenge for chemicals.
Green synthesis of metal oxide nanostructures using naturally occurring compounds for energy, environmental, and bio-related applications
Authors: Yuliarto Brian , Septiani Ni Luh Wulan , Kaneti Yusuf Valentino , Iqbal Muhammad , Gumilar Gilang , Kim Minjun , Na Jongbeom , Wu Kevin C.-W. , Yamauchi Yusuke
Published: September 2019

This review summarizes the synthesis and functional applications of metal oxide nanostructures synthesized using plant-derived phytochemicals for energy, environmental, and biomedical applications.
Water-resistant HKUST-1 functionalized with polydimethylsiloxane for efficient rubidium ion capture
Authors: Tian Ning , Gao Yuan , Wu Jiafei , Luo Suqing , Dai Wei
Published: September 2019

A thin hydrophobic layer of polydimethylsiloxane (PDMS) was successfully coated onto HKUST-1 by a facile chemical vapor deposition (CVD) approach, which enables excellent Rb(i) capture in water.
Fermi-level pinning in methylammonium lead iodide perovskites
Authors: Gallet Thibaut , Grabowski David , Kirchartz Thomas , Redinger Alex
Published: September 2019

Scanning tunnelling microscopy measurements reveal grain dependent changes in surface state density and workfunctions on polycrystalline CH3NH3PbI3 absorbers.
Layer-dependent dielectric and optical properties of centimeter-scale 2D WSe2: evolution from a single layer to few layers
Authors: Gu Honggang , Song Baokun , Fang Mingsheng , Hong Yilun , Chen Xiuguo , Jiang Hao , Ren Wencai , Liu Shiyuan
Published: September 2019

The excitonic effect and JDOS dominated evolution in layer-dependent dielectric and optical properties of 2D WSe2 were investigated by spectroscopic ellipsometry.
Synthesis of imidazo[1,2-c]thiazoles through Pd-catalyzed bicyclization of tert-butyl isonitrile with thioamides
Authors: Peng Xiangjun , Qin Feng , Xu Mengyue , Zhu Shaojie , Pan Yingming , Tang Haitao , Meng Xiujin , Wang Hengshan
Published: September 2019

We report herein the synthesis of imidazo[1,2-c]thiazoles through a Pd-catalyzed insertion reaction of three isonitrile molecules and cascade bicyclization in a one-pot, two-step process.
Multicolor tunable luminescence and laser-sensitization induced upconversion enhancement in Ln-doped Gd2O3 crystals for anti-counterfeiting
Authors: Zheng Wei , Sun Baoyu , Li Yuemei , Wang Rui , Xu Yanling
Published: September 2019

A feasible laser sensitization strategy enables the realization of emission enhancement and flexible color tuning in Gd2O3:Yb3+,Er3+ particles. Moreover, these materials provide a convenient route for high security anti-counterfeiting applications.
Stimuli-responsive dynamic pseudorotaxane crystals
Authors: Horie Masaki , Wang Chi-Hsien
Published: September 2019

This review summarizes recent advances in dynamic pseudorotaxane crystals with response to external stimuli, such as light and/or heat.
Study of the pore structure and size effects on the electrochemical capacitor behaviors of porous carbon/quinone derivative hybrids
Authors: Itoi Hiroyuki , Tazawa Shuka , Hasegawa Hideyuki , Tanabe Yuichiro , Iwata Hiroyuki , Ohzawa Yoshimi
Published: September 2019

We investigated the redox reaction of a quinone derivative within the pores of porous carbons, which is affected by the pore sizes and structures of the porous carbons.
Associative behavior of polyimide/cyclohexanone solutions
Authors: Chen Hongxiang , Liu Wei , Hong Mei , Zhang Ensong , Dai Xuemin , Chen Quan , Yang Wenke , Xue Yanhu , Qiu Xuepeng , Ji Xiangling
Published: September 2019

Enhancing the relatively weak interaction strength through varying the solvent quality can transform PI from a neutral polymer to an associative polymer.
Metal-free oxidative cross-dehydrogenative coupling of quinones with benzylic C(sp3)–H bonds
Authors: Dong Yu , Yang Jian , He Shuai , Shi Zhi-Chuan , Wang Yu , Zhang Xiao-Mei , Wang Ji-Yu
Published: September 2019

A metal-free cross-dehydrogenative coupling of quinones with toluene derivatives has been established. A series of quinones were subjected to reaction with toluene derivatives in the presence of DTBP for direct synthesis of benzylquinones.
Vanadium occupation and its leachability differences in trioctahedral and dioctahedral mica
Authors: Zheng Qiushi , Zhang Yimin , Xue Nannan , Liu Tao , Huang Jing
Published: September 2019

Vanadium in black shale prefers to locate in the octahedron of mica and can be more easily released from trioctahedral mica than dioctahedral mica.
Chemistry in supercritical fluids for the synthesis of metal nanomaterials
Authors: Xu Yu , Musumeci Valentina , Aymonier Cyril
Published: September 2019

The supercritical flow synthesis of metal nanomaterials is sustainable and scalable for the efficient production of materials.
A review on strategies addressing interface incompatibilities in inorganic all-solid-state lithium batteries
Authors: Gurung Ashim , Pokharel Jyotshna , Baniya Abiral , Pathak Rajesh , Chen Ke , Lamsal Buddhi Sagar , Ghimire Nabin , Zhang Wen-Hua , Zhou Yue , Qiao Qiquan
Published: September 2019

This review focuses on recent advances in interface engineering of solid-state batteries based on inorganic oxide and sulfide solid electrolytes.
A traction force threshold signifies metastatic phenotypic change in multicellular epithelia
Authors: Zhang Yao , Shi Xuechen , Zhao Tiankai , Huang Changjin , Wei Qiong , Tang Xin , Santy Lorraine C. , Saif M. Taher A. , Zhang Sulin
Published: September 2019

Using extracellular matrix control of cellular mechanics, we establish that cellular force threshold can also mark in vitro metastatic phenotypic change and malignant transformation in HCT-8 cell colonies.
Nano-engineering and micromolecular science of polysilsesquioxane materials and their emerging applications
Authors: Ahmed Numan , Fan Hong , Dubois Philippe , Zhang Xianwei , Fahad Shah , Aziz Tariq , Wan Jintao
Published: September 2019

Polysilsesquioxanes (RSiO1.5)n are organic–inorganic hybrid materials that have an array of properties and synergistic features and are considered to be robust materials in the family of siliceous compounds.
Novel carbon and sulfur-tolerant anode material FeNi3@PrBa(Fe,Ni)1.9Mo0.1O5+δ for intermediate temperature solid oxide fuel cells
Authors: Xue Shuangshuang , Shi Nai , Wan Yanhong , Xu Zheqiang , Huan Daoming , Zhang Shaowei , Xia Changrong , Peng Ranran , Lu Yalin
Published: September 2019

PBFMNi0.3 perovskite with in situ exsolved FeNi3 nano-catalysts is a promising carbon- and sulfur-tolerant anode for IT-SOFCs.
Synthesis and water oxidation electrocatalytic and electrochromic behaviours of mesoporous nickel oxide thin film electrodes
Authors: Amirzhanova Assel , Karakaya Irmak , Uzundal Can Berk , Karaoğlu Gözde , Karadas Ferdi , Ülgüt Burak , Dag Ömer
Published: September 2019

A molten salt assisted self-assembly method has been employed to produce mesoporous nickel oxide thin films that have a large surface area, efficient water oxidation electrocatalytic performance and good electrochromic properties.
Halogen-substituted triphenylamine derivatives with intense mechanoluminescence properties
Authors: Tu Jin , Fan Yunhao , Wang Jiaqiang , Li Xiaoyu , Liu Fan , Han Mengmeng , Wang Can , Li Qianqian , Li Zhen
Published: September 2019

Three TPA derivatives show different ML effects due to the various electronic structures modulated by the introduction of halogen atoms.
Academic Edge: Are New York State CSD Programs Ready for Autism? Is Anyone?
Authors: Battaglia Dana , Domingo Robert , Moravcik Gina-Marie
Published: September 2019

How does autism-related content in New York graduate speech-language pathology programs stack up?
Academic Edge: This Isn't the Same Old Book Learning
Authors: Friberg Jennifer , Ginsberg Sarah , Visconti Colleen , Schober-Peterson Debra
Published: September 2019

Learn about interprofessional education and patient simulations at the 2013 ASHA Convention.
Time Block After Time Block
Authors: Rudebusch Judy , Wiechmann JoAnn
Published: September 2019

To offer a full range of RTI and IEP services, school-based SLPs can schedule activity blocks rather than go student by student—here's how.
Baseline Benefits
Authors: Ratner Nan , Gaillard William , Berl Madison , Strekas Amy
Published: September 2019

We may not know why children with epilepsy have speech and language challenges, but we do know they often struggle socially and academically. Armed with baseline and subsequent assessments, SLPs can provide the intervention these children need.
Make It Work: Handling a Hard Conversation
Authors: Stone-Goldman Judy
Published: September 2019

One of the toughest things we clinicians do is break bad news to clients. These tips can help ease the pain—for you and for them.
Policy Analysis: New Patient Privacy Rules Take Effect
Authors: Havens Laurie
Published: September 2019

SLPs and audiologists need to know about HIPAA revisions that affect subcontractors, privacy practice notices, enforcement, genetic information and more.
Policy Analysis: Autism and Cognitive Communication Codes Don't Go Together
Authors: McCarty Janet
Published: September 2019

SLPs treating clients with autism should continue to use the speech-language disorder and autism codes on documentation.
SIGnatures: The Quest for Voice Assessment Guidelines
Authors: Hillman Robert
Published: September 2019

SIG 3 spearheaded the development of a standard method for perceptual evaluation of voice quality—and is on the way to developing clinical protocols for the instruments commonly used in voice assessment.
SIGnatures: Push-In Services: Making the 'Impossible' Possible
Authors: Dixon Deborah
Published: September 2019

Push-in services are touted as efficient and time-saving, but many SLPs report not including them. The reasons are varied, but there are ways to persevere and integrate this method smoothly.
XMMSL2 J144605.0+685735: a slow tidal disruption event
Authors: Saxton R. D. , Read A. M. , Komossa S. , Lira P. , Alexander K. D. , Steele I. , Ocaña F. , Berger E. , Blanchard P.
Published: September 2019

Aims.We investigate the evolution of X-ray selected tidal disruption events.

Methods.New events are found in near real-time data fromXMM-Newtonslews, and are monitored by multi-wavelength facilities.

Results.In August 2016, X-ray emission was detected from the galaxy XMMSL2 J144605.0+685735 (also known as 2MASX 14460522+6857311), that was 20 times higher than an upper limit from 25 years earlier. The X-ray flux was flat for ∼100 days and then fell by a factor of 100 over the following 500 days. The UV flux was stable for the first 400 days before fading by a magnitude, while the optical (U,B,V) bands were roughly constant for 850 days. Optically, the galaxy appears to be quiescent, at a distance of 127 ± 4 Mpc (z = 0.029 ± 0.001) with a spectrum consisting of a young stellar population of 1–5 Gyr in age, an older population, and a total stellar mass of ∼6 × 109 M⊙. The bolometric luminosity peaked atLbol ∼ 1043ergs s−1with an X-ray spectrum that may be modelled by a power law of Γ ∼ 2.6 or Comptonisation of a low-temperature thermal component by thermal electrons. We consider a tidal disruption event to be the most likely cause of the flare. Radio emission was absent in this event down to < 10 μJy, which limits the total energy of a hypothetical off-axis jet toE <  5 × 1050ergs. The independent behaviour of the optical, UV, and X-ray light curves challenges models where the UV emission is produced by reprocessing of thermal nuclear emission or by stream-stream collisions. We suggest that the observed UV emission may have been produced from a truncated accretion disc and the X-rays from Compton upscattering of these disc photons.
A Preventive Strategy of Voltage Stability based on Characteristic Analysis
Authors: Hu Zhen , Wang Ding , Shen Yangwu , Chen Daojun , Liu Yongyan
Published: September 2019

The purpose of voltage stability prevention and control strategy is to minimize the impact of expected accidents on the whole power grid while ensuring safe power supply. In this paper, it is expected that the accident has a large impact on the system voltage and makes the voltage margin of each node low. in order to not only adjust the node voltage, but also reduce the disturbance impact, a voltage stability prevention and control strategy is proposed based on the characteristic analysis.
Approximation Methods for FO-IMC Controllers for Time Delay Systems
Authors: Muresan Cristina I. , Birs Isabela R. , Prodan Ovidiu , Nascu Ioan , De Keyser Robin
Published: September 2019

Fractional Order Internal Model Control (FO-IMC) is among the newest trends in extending fractional calculus to the integer order control. Approximation of the FO-IMC is one of the key problems. Apart from this, when dealing with time delay systems, the time delay needs also to be approximated. All these approximations can alter the closed loop performance of the controller. In this paper, FO-IMC controllers will be tested in terms of the approximation accuracy. The case study is a first order system with time delay. Several scenarios will be considered, aiming for a conclusion regarding the choice of the approximation method as a function of the process characteristics, closed loop performance and FO-IMC fractional order. To approximate the time delay, two extensively used techniques will be considered, such as the series and Pade approximations. These will be compared to a novel approximation technique. An analysis of the test cases presented show that the series approximation proves more suitable in a single scenario, whereas the novel approximation method produces better results for the rest of the test cases.
Continuum limit of the nonlocal p-Laplacian evolution problem on random inhomogeneous graphs
Authors: Hafiene Yosra , Fadili Jalal M. , Chesneau Christophe , Elmoataz Abderrahim
Published: September 2019

In this paper we study numerical approximations of the evolution problem governed by the nonlocal p-Laplacian operator with a given kernel and homogeneous Neumann boundary conditions. More precisely, we consider discretized versions on inhomogeneous random graph sequences, establish their continuum limits and provide error bounds with nonasymptotic rate of convergence of solutions of the discrete problems to their continuum counterparts as the number of vertices grows. Our bounds reveal the role of the different parameters that come into play, and in particular that of p and of the geometry/regularity of the initial data and the kernel.
Dossier : Le groupe des Dix, des précurseurs de l'interdisciplinarité – Science et politique : initiatives et influence du Groupe des Dix
Authors: Chamak Brigitte
Published: September 2019

L’objectif du Groupe des Dix, créé en 1969, était d’intensifier les relations entre science et politique. Des chercheurs et des hommes politiques ont participé, entre 1969 et 1976, à des rencontres qui avaient pour but d’aider les politiques à prendre des décisions de façon plus rationnelle. L’influence du Groupe des Dix peut s’évaluer à travers l’impact des différents ouvrages rédigés par chacun de ses membres, mais aussi par la création du Centre d’études des systèmes et des technologies avancées (Cesta) sur proposition de Jacques Attali, conseiller du président de la République de 1981 à 1991. Le Cesta est à l’origine de la mise en place d’un projet de coopération technologique européenne. Il participa également, dans le cadre de la promotion des nouvelles technologies, au développement des sciences cognitives en France, en organisant, en 1985, le premier colloque rapprochant informatique, psychologie et neurobiologie.
Calf Blood Compound (CFC) and Homeopathic Drug Induce Differentiation of Primary Human Skeletal Muscle Cells
Authors: Langendorf Eva K. , Klein Anja , Rommens Pol M. , Drees Philipp , Ritz Ulrike , Mattyasovszky Stefan G.
Published: September 2019

The use of injections to treat structural muscle injuries is controversially discussed. In our controlled in vitro study, we investigated the biological impact of Actovegin and Traumeel alone and in combination on primary human skeletal muscle cells. Cells were characterized by immunofluorescence staining for myogenic factor 5 (Myf5) and MyoD, and cultured with or without Actovegin and / or Traumeel. The effects of these agents were assayed by cell viability and gene expression of the specific markers MyoD, Myf5, neural adhesion molecule (NCAM), and CD31. Myotube formation was determined by myosin staining. Neither Actovegin nor Traumeel showed toxic effects or influenced cell viability significantly. High volumes of Actovegin down-regulated gene expression of NCAM after 3 days but had no effect on MyoD, Myf5, and CD31 gene expression. High volumes of Traumeel inhibited MyoD gene expression after 3 days, whereas after 7 days MyoD expression was significantly up-regulated. The combination of both agents did not significantly influence cell viability or gene expression. This is the first study demonstrating that Actovegin and Traumeel potentially modulate human skeletal muscle cells. The relevance of these in vitro findings has to be highlighted in further in vivo studies.
Post-exercise Hypotension Produced by Supramaximal Interval Exercise is Potentiated by Angiotensin Receptor Blockers
Authors: Ramirez-Jimenez Miguel , Morales-Palomo Felix , Ortega Juan Fernando , Mora-Rodriguez Ricardo
Published: September 2019

We studied the effects of supramaximal interval exercise (SIE) with or without antihypertensive medication (AHM) on 21-hr blood pressure (BP) response. Twelve hypertensive patients chronically medicated with AHM, underwent three trials in a randomized order: a) control trial without exercise and substituting their AHM with a placebo (PLAC); b) placebo medicine and a morning bout of SIE (PLAC+SIE), and c) combining AHM and exercise (AHM+SIE). Acute and ambulatory blood pressure responses were measured for 21-hr after treatment. 20  min after treatment, systolic blood pressure (SBP) readings were reduced, similar to readings after PLAC+SIE (−9.7±6.0 mmHg, P<0.001) and AHM+SIE (−10.4±7.9 mmHg, P=0.001). 21 h after treatment, SBP remained reduced after PLAC+SIE (125±12 mmHg, P=0.022) and AHM+SIE (122±12 mmHg, P=0.013) compared to PLAC (132±16 mmHg). The BP reduction in PLAC+SIE faded out at 4 a.m., while in AHM+SIE it continued overnight. At night, BP reduction was larger in AHM+SIE than PLAC+SIE (–5.6±4.0 mmHg, P=0.006). Our data shows that a bout of supramaximal aerobic interval exercise in combination with ARB medication in the morning elicits a sustained blood pressure reduction lasting at least 21-h. Thus, the combination of exercise and angiotensin receptor blocker medication seems superior to exercise alone for acutely decreasing blood pressure.
Arzneimittelsicherheit und Pharmakovigilanz aus Sicht der Arzneimittelkommission der deutschen Ärzteschaft
Authors: Stammschulte Thomas , Köberle Ursula , Peter Hans-Hartmut , Pitzer Martina , Gundert-Remy Ursula
Published: September 2019

Spontanmeldungen von Nebenwirkungen durch Ärzte sind ein wichtiger Baustein der Pharmakovigilanz und tragen dazu bei, dass die Arzneimitteltherapie für Patienten sicherer wird. In Deutschland sind Ärzte durch das Berufsrecht aufgefordert, Nebenwirkungen von Arzneimitteln, die sie bei ihren Patienten beobachten, an die Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ) zu melden. In dem Beitrag wird der Aufbau des deutschen Pharmakovigilanzsystems erklärt und die wichtigsten Informationsquellen für Ärzte zu Nebenwirkungen und Arzneimittelsicherheit erläutert. Anhand von zwei Fallbeispielen aus der Rheumatologie wird dargestellt, wie die AkdÄ bei der Bewertung von Spontanmeldungen vorgeht und was mit den Meldungen im Weiteren passiert.
Genetische Grundlagen der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung
Authors: Grimm Oliver , Kranz Thorsten M. , Reif Andreas
Published: September 2019

Die Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) zeigt eine hohe Erblichkeit in formalgenetischen Studien. Auch im Vergleich zu anderen psychiatrischen Erkrankungen ist die Heritabilität mit fast 80 % sehr hoch. Die Symptomatik der ADHS scheint jedoch graduell in der Normalbevölkerung vorzukommen. Neuere Arbeiten schätzen den Anteil der auf Einzelnukleotidvarianten beruhenden Heritabilität auf 22 %. Welcher Bereich der molekularen Genetik diese Differenz erklärt, ist unklar. In dem vorgelegten Übersichtsartikel geben wir einen Überblick über die Analyse häufiger und seltener Varianten. Während häufige Varianten in ersten Megaanalysen mit vielen tausend Patienten erste genomweite Ergebnisse bringen, die jedoch nur wenig Varianz erklären, zeigen sich die methodisch immer noch schwierigeren Analysen von seltenen Varianten erst in ihren Anfängen. Sie erklären in einigen wenigen individuellen Fällen jedoch eine beträchtliche Varianz. Hierzu werden Beispiele gegeben und diskutiert. Für die Praxis ist die kritische Kenntnis der Genetik der ADHS weder für Therapie noch Diagnostik zwingend. Möglicherweise werden in Zukunft auch seltene Varianten häufiger diagnostiziert werden. Um eine kompetente Beratung zu gewährleisten, ist die Kenntnis des aktuellen Forschungsstandes jedoch auch für den Praktiker von Belang.
Sicherheit von JAK-Inhibitoren
Authors: Leipe Jan
Published: September 2019

Die zugelassenen Januskinase (JAK)-Inhibitoren Baricitinib und Tofacitinib haben bereits das Armamentarium hochwirksamer Therapien bei rheumatoider Arthritis, Psoriasis-Arthritis und Colitis ulcerosa erweitert. Als Alternative zu Biologika unterscheiden sie sich jedoch durch den Wirkmechanismus (Hemmung intrazellulärer Signalübertragung) und die orale Verfügbarkeit. Die Sicherheit ist jedoch ähnlich gut wie bei Biologika, am häufigsten kommen leichtgradige Infekte der oberen Atemwege vor. Verhältnismäßig seltene, aber spezifische Nebenwirkungen stellen Herpes-Zoster-Infektionen dar. Schwere Infektionen werden nur selten beobachtet. Nicht-infektiöse Nebenwirkungen beinhalten Laborwertveränderungen in Form von Zytopenien, Anstieg von Cholesterin (scheinbar ohne Erhöhung des kardiovaskulären Risikos), selten Leber- und Nierenwert-Erhöhungen sowie vermutlich ein erhöhtes Thromboembolie-Risiko bei bestimmten Risikokonstellationen.
Arzneimittelsicherheit bei der Therapie rheumatischer Erkrankungen im Kindes- und Jugendalter – Ergebnisse aus JuMBO
Authors: Klotsche Jens , Niewerth Martina , Minden Kirsten
Published: September 2019

Die juvenile idiopathische Arthritis (JIA) bedarf insbesondere bei schweren Verläufen zur Vermeidung von Folgeschäden und dauerhaften Funktionseinbußen einer konsequenten Therapie. Biologika gewinnen hier zunehmend an Bedeutung. Über deren Wirksamkeit und Sicherheit in der klinischen Routineversorgung informieren die Biologika-Register BiKeR und JuMBO. JuMBO, als Follow-up-Register von BiKeR, liefert aufgrund der Weiterbeobachtung der Patienten im Erwachsenenalter wichtige Informationen zur Langzeitsicherheit von Biologika und zum Langzeit-Outcome der JIA.

Die Daten des JuMBO-Registers bestätigen im Allgemeinen die gute Verträglichkeit der Biologika in der Langzeitanwendung. Schwere unerwünschte Arzneimittelnebenwirkungen werden selten dokumentiert, neu aufgetretene Autoimmunerkrankungen beschränken sich bisher auf wenige Einzelfälle. Ein Schwerpunkt der Sicherheitsanalysen liegt in der Kalkulation der Malignomrate bei DMARD-exponierten JIA-Patienten. Die bisher in JuMBO erfassten Fälle ließen kein erhöhtes Risiko bei Biologika-exponierten im Vergleich zu nur MTX-exponierten Patienten erkennen. Aber mit den bisher 12 gemeldeten Fällen liegt die Malignomrate in JuMBO über der in der Bevölkerung. Aufgrund der geringen Fallzahlen, der teilweisen DMARD-Mehrfachexposition dieser Patienten und der potenziellen Risikoerhöhung durch eine langanhaltende hohe Krankheitsaktivität sind die Daten jedoch mit Vorsicht zu interpretieren. Eine abschließende Beurteilung des Malignomrisikos unter Biologika-Therapie ist mit den vorliegenden Daten nicht möglich. Eine konsequente Nachbeobachtung der jungen Rheumatiker im JuMBO-Register ist unbedingt nötig, um notwendige Informationen zur Therapiesicherheit bei der JIA zu gewinnen.
Transcervical Mediastinoscopic Closure of Left-Sided Postpneumonectomy Bronchial Stump Fistula
Authors: Paleru Cristian , Cordoş Ioan , Dănăilă Olga , Bolca Ciprian
Published: September 2019

Introduction This article presents a series of patients on which the transcervical approach was used to close a left-sided postpneumonectomy fistula.

Materials and Methods The series comprises nine patients with a left pneumonectomy performed for a tuberculosis-related suppurative disease in five cases and for lung cancer in the remaining four. This procedure can be performed under certain conditions, the most important one being the length of the bronchial stump, which should be at least 1 cm, ideally 1.5 cm. The transcervical stump closure was successfully achieved in all patients, having been more technically demanding in cancer cases with previous lymphadenectomy. The postpneumonectomy infected cavity was subsequently treated.

Results The follow-up continued for at least 1 year; one individual from the cancer patients group died from an uncontrolled sepsis during the postoperative period, another one died 17 months later from metastatic cancer and two of them are alive, with no signs of neoplastic or infectious relapse 15 and 37 months, respectively, after the cervical procedure. One patient from the suppurative disease group had a relapse of the fistula 2 months after surgery, requiring additional surgical procedures to deal with this issue; all the other patients are alive, with no signs of recurrence.

Conclusions The transcervical approach is a very suitable maneuver in selected patients with a bronchial stump at least 1 cm long, ideally 1.5 cm.
Resonant tunnelling spectroscopy of van der Waals heterosystems
Authors: Vdovin Evgenii E. , Novoselov Konstantin S. , Khanin Yurii N.
Published: September 2019

The review concerns the most interesting aspects of (mainly experimental) resonance tunnelling spectroscopy studies of a new type of heterosystems called van der Waals heterostructures. The possibility to compose such systems is a result of the recent discovery of two-dimensional crystals, a new class of materials derived from graphene. The role of the angular mismatch of the crystal lattices of conductive graphene electrodes in the tunnelling of charge carriers between them, as well as the closely related issues associated with fulfillment of the conservation laws during tunnelling transitions are considered. The experimental results on inelastic tunnelling in the graphene/h-BN/graphene heterosystems with strong angular mismatch are discussed. The experiments made it possible to determine the phonon density of states spectra of the constituent layers and to detect and describe tunnelling transitions involving localized states of structural defects in the h-BN barrier. We consider new results of studies on tunnelling and magnetotunnelling in van der Waals heterosystems that demonstrate the possibilities of practical application of resonant tunnelling effects in, e.g., microwave engineering, based on realization of electronic devices having I – V curves with negative differential conductance (NDC) regions at tunnelling through defect levels of the barrier layers in such systems. These studies revealed two new types of heterosystems characterized by the formation of NDC regions as a result of resonant tunnelling through the defect levels in the h-BN barrier and by defect-assisted generation of tunnelling current.

The bibliography includes 40 references.
Critical configurations of solid bodies and the Morse theory of MIN functions
Authors: Ogievetsky O. V. , Shlosman S. B.
Published: September 2019

This paper studies the manifold of clusters of non-intersecting congruent solid bodies, all touching the central ball

of radius one. Two main examples are clusters of balls and clusters of infinite cylinders. The notion of critical cluster is introduced, and several critical clusters of balls and of cylinders are studied. In the case of cylinders, some of the critical clusters here are new. The paper also establishes criticality properties of clusters introduced earlier by Kuperberg.
Hyperspectral remote sensing monitoring of cyanobacteria blooms in a large South American reservoir: high- and medium-spatial resolution satellite algorithm simulation
Authors: Drozd A. , de Tezanos Pinto P. , Fernández V. , Bazzalo M. , Bordet F. , Ibañez G.
Published: September 2019

We used hyperspectral remote sensing with the aim of establishing a monitoring program for cyanobacteria in a South American reservoir. We sampled at a wide temporal (2012–16; 10 seasons) and spatial (30km) gradient, and retrieved 111 field hyperspectral signatures, chlorophyll-a, cyanobacteria densities and total suspended solids. The hyperspectral signatures for cyanobacteria-dominated situations (n=75) were used to select the most suitable spectral bands in seven high- and medium-spatial resolution satellites (Sentinel 2, Landsat 5, 7 and 8, SPOT-4/5 and -6/7, WorldView 2), and for the development of chlorophyll and cyanobacteria cell abundance algorithms (λ550 – λ650+λ800) ÷ (λ550+λ650+λ800). The best-performing chlorophyll algorithm was Sentinel 2 ((λ560 – λ660+λ703) ÷ (λ560+λ660+λ703); R2=0.80), followed by WorldView 2 ((λ550 – λ660+λ720) ÷ (λ550+λ660+λ720); R2=0.78), Landsat and the SPOT series ((λ550 – λ650+λ800) ÷ (λ550+λ650+λ800); R2=0.67–0.74). When these models were run for cyanobacteria abundance, the coefficient of determination remained similar, but the root mean square error increased. This could affect the estimate of cyanobacteria cell abundance by ~20%, yet it still enable assessment of the alert level categories for risk assessment. The results of this study highlight the importance of the red and near-infrared region for identifying cyanobacteria in hypereutrophic waters, demonstrating coherence with field cyanobacteria abundance and enabling assessment of bloom distribution in this ecosystem.