bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulatory Guidelines and Production Planning Strategies for Biosimilars in the USA
Authors: Prasanthi Dr.N.L. , Aditya N. , Sai Jeevan Sampathirao , Srinivas Varma Tadi , Srinulu Nulu Lakshmi , Venkateswara Raju Dr.K.
Published: November 2023

At present, biosimilar projects are ruling the pharma market. This article aims to show that project management is crucialin developing biosimilars. Bad project management will give a bad reputation to the organization, project cost overruns, projectschedule delays, demotivation of the project team, sustainability risk to the organization, and more over huge loss. It is the main reasonmost companies are spending more on the training of employees, particularly on project management. Biosimilars are biologicalproducts that are highly similar to a reference product despite modest changes in therapeutically inactive components. Biosimilarshave no clinically significant changes in product safety, purity, or potency compared to the reference product. With the imminentpatent expiration of certain important high-cost biologics, biosimilar manufacture is becoming increasingly profitable for firms.However, the introduction of biosimilars necessitates the adoption of critical new rules. Because of the inherent differences involvedwith the production methods used by different companies and even different sites within the same company, the existing standardsthat regulate the approval pathways for generic pharmaceuticals are insufficient for biosimilars. Biosimilars are similar to but notidentical to the original. Due to the exclusive nature of the manufacturing line and the techniques employed by these competitors,basic variances in methodology may exist between competing organizations. Even modest variations in the manufacturing process canresult in micro heterogeneity, characterized by minor differences in molecular structure, stability, production cell line behavior, growthconditions, vectors, and purification methods. For these reasons, developing biosimilars takes a lot of work.1 CBER regulatesbiosimilars in the US Market. The reference Medicine's Patent status and market potential should be considered when developingbiosimilars. The main objective of this article is to show that the project management strategies and regulatory approval process areequally important to enter biosimilars into the market. Concerning quality in the project management of biosimilar products, budget,deadlines, and scopes are major constraints. A Gantt chart has been enacted to represent a graphical illustration of a schedule. Ganttchart helps to plan, coordinate, and track specific tasks in a project.
Analisis Kebutuhan Komik Islami sebagai Suplemen Media Pembelajaran Sistem Sirkulasi untuk SMA/MA
Authors: Mardiah Andara Vasya , Relsas Yogica Relsas Yogica
Published: November 2023

MAN 2 Padang is a school that has different characteristics from the usual public schools. The school which is under the auspices of the Ministry of Religion has an Islamic nuance with its vision, namely "Superior Madrasas and have good morals". This is of course very much in line with the goals of national education in terms of the affective domain contained in the 2013 curriculum in KI-1 and KI-2 which requires the application of social and spiritual attitudes to students. This study aims to determine the need for Islamic comics as a supplement to the circulation system learning media for SMA/MA. The method used is interviews and filling out observation questionnaires by teachers and students. Data analysis used descriptive analysis and the percentage of the results of the number of answers given to all respondents was multiplied by 100%. The results of this study are the unavailability of learning media that includes the application of social and spiritual attitudes that attract students' interest and motivation to learn, especially on the material of the circulation system. So it can be said that the need for the development of Islamic comics as a supplement to the circulation system learning media for SMA/MA.
Key words: Develeopment, Islamic Comic, Circulation System
 
ABSTRAK
MAN 2 Padang merupakan sekolah yang memiliki karakteristik berbeda dengan sekolah umum biasanya. Sekolah yang berada di bawah naungan Kementerian Agama ini bernuansa islami dengan visinya yaitu “Madrasah yang unggul dan berakhlaqul karimah”. Hal ini tentu sangat sesuai dengan tujuan pendidikan nasional dari segi ranah afektif yang tertuang dalam kurikulum 2013 pada KI-1 dan KI-2 yang menuntut adanya penerapan sikap sosial dan spiritual pada peserta didik. Penelitian ini bertujuan untuk mengetahui kebutuhan komik Islami sebagai suplemen media pembelajaran sistem sirkulasi untuk SMA/MA. Metode yang digunakan adalah berupa wawancara dan pengisian angket observasi oleh guru dan peserta didik. Data analisis menggunakan analisis dekripstif dan persentase dari hasil jumlah jawaban yang diberikan dibagi jumlah seluruh responden dikali 100%. Hasil penelitian ini adalah belum tersedianya media pembelajaran yang mencakup penerapan sikap sosial dan spiritual yang menarik minat dan motivasi belajar peserta didik khususnya pada materi sistem sirkulasi. Sehingga dapat disimpulkan bahwa perlunya pengembangan komik islami sebagai suplemen media pembelajaran sistem sirkulasi untuk SMA/MA.
Kata kunci: Pengembangan, Komik Islami, Sistem Sirkulasi
Pentingnya Teknologi pada Sistem Pembelajaran Dalam Jaringan di masa Bencana Kabut Asap Akibat Kebakaran Hutan dan Lahan di Kota Jambi
Authors: Silitonga Mangudor , Zaharah Zaharah
Published: November 2023

The haze disaster that hit the city of Jambi resulted in kindergarten, elementary, middle and high school students being sent home and the learning process being carried out using an online system. The use of digital tecnology such as smartphones, website, and other can be integrated into learning methodes in the education sector. There are many obstacles experienced, but there are also many advantage to this online system. Teenagers, especially junior high school students, really need support from outside, and this cannot be separated from the motivation that must come from themselves to avoid misuse of technology. Rhe research methode used in this incident contained several stages, namely starting whit identifying the problem that existed on site. After that, study and understand the theoretical basis and relevant concepts that support the research which is called a literatur review study. The sources for this literature study are books, similar research journals, and other reference. The aim of this research is to determine the role of technology in online learning system during the haze disaster caused by forest and land fires in the city of Jambi. The results of the research are that the use of technology in online learning makes it very easy for students and teacher to access learning anywhere and at any time.
Abstrak. Bencana kabut asap yang melanda kota Jambi mengakibatkan siswa TK, SD, SMP dan SMA dirumahkan dan  proses pembelajaran dilaksanakan dengan sistem daring. Pemanfaatan teknologi digital seperti smartphone, situs website, dan lainnya dapat diintegrasikan dalam metode pembelajaran di bidang pendidikan. Banyak kendala yang dialami, namun banyak juga kelebihan dari sistem pembelajaran daring ini. Anak-anak remaja terlebih anak Sekolah Menengah Pertama sangat membutuhkan dukungan dari luar, juga tak terlepas dari motivasi yang harus berasal dari dirinya sendiri untuk menghindari penyalahgunaan teknologi. Metode penelitian yang digunakan pada peristiwa ini terdapat beberapa tahapan, yaitu diawali dengan mengidentifikasi masalah yang ada di tempat. Setelah itu, mempelajari dan memahami landasan teori dan konsep relevan yang mendukung dalam penelitian yang disebut dengan studi literatur review. Adapun sumber studi literatur ini adalah buku, jurnal penelitian sejenis, dan referensi lainnya. Tujuan penelitian ini adalah mengetahui peranan teknologi  pada sistem pembelajaran daring di  masa bencana kabut asap akibat kebakaran hutan dan lahan di kota Jambi. Hasil penelitian adalah penggunaan teknologi dalam  pembelajaran daring sangat memudahkan  siswa dan guru untuk  mengakses pembelajaran dimana pun serta kapan saja.
Identification of Medicinal Plants Used by the Community of Watumite Village, Nangapanda District, Ende Regency as a Biology Learning Media
Authors: Bara Feliks A. , Ndukang Sardina , Nau Getrudis Wilhelmina
Published: November 2023

The aim of the research is to find out the types of medicinal plants used by the Watumite Village community, find out how to use each type of medicinal plant used and find out what medicinal plant booklets are used by the Watumite Village community. Watumite Village community is suitable for use as a biology learning medium. The type of research used is research and development with the ADDIE model (analysis, design, development, implementation, evaluation). This research uses a qualitative and quantitative descriptive approach. The qualitative approach used is to describe the types of medicinal plants used by the Watumite Village community. Meanwhile, a quantitative approach was carried out by calculating the results of the validation of the booklet developed which was then analyzed descriptively. The results of research on medicinal plant identification based on interviews with 10 respondents living in 4 hamlets in Watumite Village obtained 32 types of medicinal plants originating from 22 families. The findings of 32 types of medicinal plants packaged as Biology learning media in booklet form have been validated by material experts and media experts with a percentage value of 85% from material experts and 84% from media experts, declared valid. The conclusions from this research are: (1) There are 32 types of medicinal plants used by the community in Watumite Village; (2) The use of each type of medicinal plant includes the part of the plant used as medicine, the type of disease treated, and the method of processing; (3) Development of a Medicinal Plants booklet for the Watumite Village Community is categorized as suitable as a biology learning medium.
“Gear-Driven”-Type Chirality Transfer of Tetraphenylethene-Based Supramolecular Organic Frameworks for Peptides in Water
Authors: Yan Chaochao , Li Qingfang , Wang Kaige , Yang Wanni , Han Jingyu , Li Yawen , Dong Yunhong , Chu Dake , Cheng Lin , Cao Liping
Published: November 2023

Chirality transfer for natural chiral biomolecules can reveal the
indispensable role of chiral structures in life and can be used to
develop the chirality-sensing biomolecular recognition. Here, we report
the synthesis and characterization of a series of achiral supramolecular
organic frameworks (SOF-1, SOF-2, and SOF-3), constructed from
cucurbit[8]uril (CB[8]) and tetraphenylethene (TPE) derivatives
(1, 2, and 3), respectively, as chirality-sensing platforms to explore
their chirality transfer mechanism for peptides in water. Given the
right-handed (P) and left-handed (M) rotational conformation of TPE
units and the selective binding of CB[8] to aromatic amino acids,
these achiral SOFs can be selectively triggered in water by peptides
containing N-terminal tryptophan (W) and phenylalanine (F) residues into
their P- or M-rotational conformation, exhibiting significantly
different circular dichroism (CD) spectra. Although various peptides
have the same L-type chiral configuration, they can induce positive CD
signals of SOF-1 and negative CD signals of SOF-2 and SOF-3,
respectively. Based on the structural analysis of the linkage units
between CB[8] and TPE units in these SOFs, a “gear-driven”-type
chirality transfer mechanism has been proposed to visually illustrate
the multiple-step chirality transfer process from the recognition site
in the CB[8]’s cavity to TPE units. Furthermore, by utilizing the
characteristic CD signals generated through the “gear-driven”-type
chirality transfer, a series of SOFs can serve as chiroptical sensor
arrays to effectively recognize and distinguish various peptides based
on their distinctive CD spectra.
Machine Learning-enabled Optimization of Melt Electro-Writing 3D Printing
Authors: Abdullah Ahmed , Ozarslan Olgac , Farshi Sara , Dabbagh Sajjad Rahmani , Tasoglu Savas
Published: November 2023

Melt electrowriting (MEW) is a solvent-free (i.e., no volatile
chemicals), high-resolution 3D printing method that enables the
fabrication of semi-flexible structures with rigid polymers. Despite its
advantages, the MEW process is sensitive to changes in printing
parameters (e.g., voltage, printing pressure, and temperature), which
can cause fluid column breakage, jet lag, and/or fiber pulsing,
ultimately deteriorating the resolution and printing quality. In spite
of the commonly used error-and-trial method to determine the most
suitable parameters, here, we present a machine learning (ML)-enabled
image analysis-based method for determining the optimum MEW printing
parameters through an easy-to-use graphical user interface (GUI). We
trained 5 different ML algorithms using 168 MEW 3D print samples, among
which the gaussian process regression ML model yielded 93% accuracy of
the variability in the dependent variable, 0.12329 on root mean square
error for the validation set and 0.015201 mean square error in
predicting line thickness. Integration of ML with control feedback loop
and MEW can reduce the error-and-trial steps prior to the 3D printing
process, decreasing the printing time (i.e., increasing the overall
throughput of MEW) and material waste (i.e., improving the
cost-effectiveness of MEW). Moreover, embedding trained ML model with
the feedback control system in a GUI facilitates a more straightforward
use of ML-based optimization techniques in the industrial section (i.e.,
for users with no ML skills).
Extreme hydroclimatic events compromise adaptation planning in agriculture based on long-term trends
Authors: Moravec Vojtěch , Markonis Yannis , Trnka Miroslav , Hanel Martin
Published: November 2023

Climate projections suggest an increase in drought frequency and
intensity in various places over the globe, one of them being Southern
Europe, expected to become a hotspot. However, 2018 presented an anomaly
with the emergence of a rare “water seesaw” phenomenon, leading to
severe drought in Central and Northern Europe while Southern Europe
experienced high humidity. This unexpected event resulted in significant
agricultural disparities, emphasizing the influence of interannual
variability. The commentary underscores the danger of overlooking
short-term climate variability, vital for accurate adaptation planning,
especially for vulnerable regions, when focusing solely on long-term
trends. This case serves as a motivation for exploration of global
atmospheric circulation changes, emphasizing the need for nuanced
modeling approaches to grasp subtle complexities in climate predictions
and considering short-term climate variability alongside long-term
trends.
Comparative analysis of affective achievement between innovative high school and general high school in Gyeonggi province
Authors:   The Korean Society for the Study of Local Education Management, Choi Young Jin , Kim Young Sik
Published: November 2023

Using the data for 8th of the GEPS, this study analyzed and compared affective achievement between innovative and general high school students. To compare high school students’ self-esteem, self-efficacy, school satisfaction and career planning between 2 types of high schools, this study utilized t-test and multiple regression analysis. The results of this study show that firstly, innovative high school students’ school satisfaction was higher than that of general high school students. On the other hand, in terms of self-efficiency, general high school showed more positive result than innovative high school. Second, in the analysis with multiple regression model, innovative high school students’ school satisfaction and self-respect were significantly higher than those of general high school students. Based on the above results, this study suggested that more rigorous research design is needed through follow-up studies and we need to develop more effective innovative school programs to improve students’ self-efficacy and career competency.
Exploring the Effectiveness of Teachers' Blogs as Self-Supervision
Authors:   The Korean Society for the Study of Local Education Management, Kim Seong Eun , Lee Jae Duk
Published: November 2023

Recently, as non-face-to-face classes have been activated due to the influence of COVID-19, teachers' SNS-based activities such as blogs and YouTube have become very active. Teachers produce and share various materials in the online space, such as their educational activities, administrative works, and philosophy about education. Noting that these activities will contribute to the improvement of teachers' expertise, the researcher tried to clarify through examples how blogs operated by teachers enhance teachers' expertise from the perspective of supervision. In this study, through interviews with five teachers operating blogs on educational activities, it was confirmed that teacher blogs have some function as a portfolio that records teachers' career, and are gaining the effect of self-supervision of developing expertise on their own. By analyzing related literature and synthesizing interview results, the functions of teacher blogs are classified into record preservation, self-reflection, and data sharing, and reinterpreted from the perspective of self-supervision. In conclusion, teacher blogs should be recognized as a category of self-supervision because they contribute to enhancing teachers' professionalism, and schools and offices of education suggested that teachers should work on ways to further develop their supervision culture.
A Exploratory Study on the Improvement of School Governance through the Management System Theory of Likert
Authors:   The Korean Society for the Study of Local Education Management, Hwang Junghun , Eom Moonyoung
Published: November 2023

This study analyzed the components of school governance in Korea using the management system theory of Likert (1976). In school governance, organizations such as student associations, teachers' associations, and parents' associations and organizations such as school management committees that connect each subject to each other have a multi-overlapping structure. The structure of school governance in Korea has a linking pin structure emphasized in System 4, but it can be seen that the level of the system is determined by which stage each subject acts in the system decision variable proposed by Likert (1976). Therefore, as a way to improve the effective operation of school governance, first, all participating entities in school governance should create a shared vision and achieve cognitive and emotional consent. Second, the horizontal and democratic consciousness of school managers should be deeply rooted in the entire organization. Third, decision-making authority should be equally distributed to all subjects. Fourth, at the level of the communitiy of village education, it is necessary to systematically supplement the linking pin structure that closely connects unit schools, communities, and basic local governments.
Analysis of the perceptions on the improvement of the Teacher Evaluation system
Authors:   The Korean Society for the Study of Local Education Management, Jung Sung Soo , Ahn Hong Seon
Published: November 2023

This study was conducted for the purpose of examining perceptions and finding the right direction for future teacher evaluation system. In order to achieve the research purpose, an interview survey was conducted with interested parties who participated in the evaluation after the completion of the evaluation of teacher competency development in 2021. As a result of the study, the overall positive perception of system improvement was high, but negative perceptions and concerns were also significant. It was suggested that system improvement through more in-depth research and investigation was necessary for matters in which there was a particularly large difference in perceptions between the evaluation subjects(between teachers and parents) regarding the same system improvement items. Based on the research results, it is suggested to establish a plan for using specific evaluation results to enhance the professionalism of teachers, design customized evaluation questions for evaluation purposes and evaluation subjects, and seek ways for each school level, region, and evaluation subject to increase the evaluation participation rate. did.
Analysis of Policy Process in Seoul Innovation Education District : Focusing on Kingdon's Multi-Flow Model
Authors:   The Korean Society for the Study of Local Education Management, Kim Bo Young , Lee Seung Ho
Published: November 2023

This study aims to re-examine policy development plans and derive implications by analyzing the policy agenda setting process and policy decision process using Kingdon's policy flow model for the Seoul Innovation Education District, which is different from other educational policy projects. Accordingly, the analysis period was set from 2010 when the innovation education district policy was proposed to 2015 when the Seoul-type innovation education district policy was started until recently, and Bigkinds analysis and related literature analysis were conducted. As a result of the analysis, the flow of policy issues was constantly raised due to complaints about public education, controversy over welfare direction in education, school violence, and suicide rate, and the flow of policy alternatives was analyzed as attempts to spread the performance of innovative schools to general schools, bridge the educational gap, and the growth of the village education community. The flow of politics was analyzed as the biggest trend of the direct election system of the superintendent of education, and it was analyzed that the combination of these flows opened a total of three times. As the first policy window was introduced, the Seoul Innovation Education Zone policy was implemented with the first election of the liberal Seoul Superintendent in 2012, and the second policy window was analyzed to have laid the legal basis for the project with the enforcement of the Seoul Innovation Education Zone Ordinance in 2016. The last window of the third policy was analyzed that all autonomous districts in Seoul implemented the Seoul Innovation Education District project in 2019 and the project was expanded. Based on the analysis results, first, the initial purpose of the Seoul Innovation Education District policy should not be lost. Second, it is necessary to organize the concept of the village education community and establish a system that can be actively and autonomously operated. Third, it drew implications for considering the sustainability of the Seoul Innovation Education District policy, which has a strong influence on the political flow, and finding alternatives.
An Analysis of Busan Innovation Education District in Collaborative Governance Perspective
Authors:   The Korean Society for the Study of Local Education Management, Park Jin Hyoung
Published: November 2023

This study analyzed the process of establishing public-private-school governance in the Da-Haengbok Education District, an innovation education district in Busan. By applying the collaborative governance model of Ansell & Gash, the starting conditions, institutional design, facilitative leadership, and collaborative process of the Da-Haengbok Education District project were analyzed step by step. As a result of the analysis, the Da-Haengbok Education District constituted most of the factors suggested by the cooperative governance model. In spite of the starting conditions such as the imbalance of capacity between administrative districts and the private sector, stable public-private-school governance was established by encouraging the participation of each member on the principle of cooperation and agreement. In order to overcome the starting conditions, a strategy was operated to actively induce the participation of the private sector in governance and formalize common responsibilities and authorities through agreements with local governments. Based on face-to-face conversation, initial distrust was overcome and trust was formed. The project was carried out by limiting regional leadership and focusing on district-level facilitating leadership. Understanding was shared through sharing of various achievements and networks, and a virtuous cycle structure was able to be formed that strengthened trust and commitment.
Exploring the Future Direction for Youth Employment Policy Using Latent Class Analysis - Focused on NEET -
Authors:   The Korean Society for the Study of Local Education Management, Yoon Sohee , Kim Jehyun
Published: November 2023

Due to the need for a customized approach to NEET, in this study we aim to explore the future direction for youth employment policy by utilizing latent class analysis focusing on NEET. In this study we used the 2016GoMS(Graduate Occupational Mobility Survey) data provided by the Korea Employment Information Service. The latent class type of economically inactive youth NEET was derived using latent class analysis, and the demographic and sociological characteristics of the type were examined using logistic regression analysis. The findings of the study were as follows.
First, as a result of deriving the potential class types of NEET using latent class analysis (LCA), there were a total of three types: job preparation (12.1%), career deficiency (28.5%), and opportunity-seeking (60.4%). Second, as a result of examining the characteristics of each type of potential class based on gender, age, and school type using logistic regression, there were no statistically significant results.
In conclusion, given the unique landscape of Korea, characterized by a high proportionof highly educated NEET as well as the types of economically inactive youth NEET derived from this study, it is necessary to have a policy to guarantee a higher quality of life by connecting one's job and daily life.
Pyogenic liver abscess as an extra-intestinal manifestation of pediatric Crohn’s disease
Authors: Bae Ju Yeon , Kim Hansol , Kim Seon Young , Yoo So Yeong , Jeon Tae Yeon , Hwang Inwoo , Ahn Soomin , Choe Yon Ho , Kim Mi Jin , Kim Yoon Zi
Published: November 2023

Crohn’s disease (CD) is a type of inflammatory bowel disease (IBD) characterized by chronic granulomatous inflammation of any part of the body, primarily the gastrointestinal (GI) tract, and is increasing in incidence worldwide. As CD is a systemic disease, the features of CD typically manifest in the GI tract; however, a variety of extra-intestinal manifestations, such as the involvement of joints, skin, and eyes may also occur. Although pyogenic liver abscess itself is rare in the general population (approximately 3–5 per 100,000 hospital admissions), it is also an unusual and rare presentation in pediatric CD patients. In this report, we present a case of pyogenic liver abscess in a 7-year-old female CD patient and discuss the clinical features, laboratory findings, imaging studies, and pathologic report of liver biopsy.
Zonguldak Kent Kimliği Bileşenlerinin Coğrafi Analizi
Authors: Siyavuş Ahmet Emrah
Published: November 2023

Kuruldukları mekânın ve barındırdıkları toplumun yansıması olan şehirler, sahip olduğu fizikî ve beşerî coğrafya özelliklerinden dolayı birbirinden ayrılmaktadırlar. Ancak son yıllarda yaşanan küreselleşme ile kentler kendine özgü olan kimliklerinden uzaklaşmakta ve birbirlerine benzemektedirler. Bu bakımdan çalışmada Zonguldak şehrinin kurulu bulunduğu mekandaki coğrafi özelliklerin şehrin kimliği üzerindeki etkisi incelenmiştir. Zonguldak kent kimliğini temsil eden unsurlar ön plana çıkartılarak, söz konusu kimlik unsurlarının sürdürebilir hale getirilmesine katkıda bulunmak amaçlanmıştır. Çalışmada Zonguldak kent kimliğini temsil eden coğrafi konum, jeolojik, jeomorfolojik, klimatik, bitki örtüsü özellikleri ile tarihi, kültürel, demografik, sosyoekonomik ve sembolik özellikleri coğrafi bakış açısı ile analiz edilmiştir. Zonguldak Belediyesi ve Zonguldak Valiliği tarafından yapılan turizm tanıtımlarında kenti ön plana çıkartan unsurların neler olduğu tespit edilmiş, çalışma sahasına gidilerek kent kimliğini temsil eden faktörler yerinde incelenmiştir. Ayrıca Zonguldak şehriyle ilgili alanyazın çalışması yapılarak geçmişte ve günümüzdeki kent kimliği arasındaki benzerlik ve farklılıklar ortaya konulmuştur. Zonguldak’ın ön plana çıkan kentsel kimlik unsurları; taş kömürü, maden işçisi, Uzun Mehmet, denizi, mağaraları, dik ve dolambaçlı yolları, çeşitli anıtları ve Cumhuriyet dönemi şehri olmasıdır. Bununla birlikte Zonguldak’ta yıllardır hâkim olan taş kömürüne bağlı işçi sınıfı ve kültürünün bozulan ekonomi ve verilen göçler nedeniyle zarar görmekte olduğu anlaşılmıştır. Bu bakımdan dünyada maden rezervlerinin azalmasıyla göçü önlemek ve kent kimliğini korumak adına çeşitli çalışmaların yapıldığı şehirlere dair örnekler sunulmuştur.
An Investigation into the Prospective EFL Teachers Conceptions Regarding Teaching and Learning and Metaphorical Conceptualizations for Teacher Roles
Authors: Sıvacı Seda
Published: November 2023

This study’s goal was to scrutinize the relationship between prospective English language teachers’ conceptions concerning teaching and learning process and metaphorical perceptions regarding their roles as language teachers. A correlational survey model was adapted in the study. The participants of the study involve 120 prospective EFL teachers at a foundation university in the 2021-2022 academic year. Data were gathered by administering the ‘Teaching and Learning Conceptions” and “Teacher Metaphor’ scales. As for the analysis the data, a series of statistical analysis through SPSS was done. At first, descriptive statistics and correlation analysis were presented and then multiple regression analysis were done. The findings showed that, prospective EFL teachers mostly prefer a constructivist approach and define their role as “guide” and “goal-oriented” teachers, while teachers who follow a traditional approach were seen as “disciplinarian-protective” teachers.
Barnets (o)fria undran. Vilka ramar ger läroplanerna för barn att utforska religiösa och existentiella frågor i finska, norska och svenska förskolor?
Authors: Cavallin Clemens , Johansson Viktor Magne , Mansikka Jan-Erik
Published: November 2023

Artikeln gör en jämförande undersökning av ramvillkoren i finska, norska och svenska nationella läroplaner för barns existentiella och religiösa funderingar i förskolan. De tre länderna hanterar religionens nya roll och relationen mellan kulturell mångfald, kulturarv och värdegrund olika. Den avgörande punkten är i hur hög grad ett sekulärt ideal förskjuter religiösa teman från förskolans pedagogiska verksamhet till en privat sfär och i vilken utsträckning kristendomens tidigare roll att forma medborgare fortfarande anses legitimt, men nu utvidgat till att inkludera också andra religioners identitetsbildning. Värden, principer och idéer i läroplanerna både begränsar och möjliggör barnets rätt till undran över livsfrågor, vilket leder till ett dynamiskt spänningsfält som inkorporeras i sociala institutioner. Detta gäller såväl i en nationell kontext som i pedagogiska situationer på förskolan. Utrymmet för undran över religiösa och existentiella frågor blir dock paradoxalt för både barnet och pedagogen när olika värden och principer motverkar varandra. 
ENGLISH ABSTRACT
The Child’s (un)free Wonder. Curricular Conditions for Children to Explore Religious and Existential Questions in Finnish, Norwegian, and Swedish Kindergartens and Pre-schools
The article is a comparative study of curricular conditions in Finland, Norway and Sweden regarding children’s existential and religious questions in early childhood education and care. The three countries diverge in how they deal with the new role of religion and the relation between cultural diversity, cultural heritage and fundamental values. The crucial point is to what degree a secular ideal has moved religious themes from daily activities in ECEC into a private sphere. A central question concerns the legitimacy of the traditional role of Christianity in shaping the identities of citizens, and by extension concerns the legitimacy of identity processes informed by other religions. Values, principles and ideas in curricula both reduce and make possible children’s right to explore existential questions, thereby creating a dynamic field of tensions that is incorporated into social institutions. This is the case both at the national level and in concrete situations within ECEC institutions. However, when values and principles counteract each other, the space for existential and religious wonder becomes paradoxical both for children and staff.
Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants
Authors: Lee Dong-Jin , Moon Jong-Seok , Song Dae Kwon , Lee Yong Seok , Kim Dong-Sub , Cho Nam-Jun , Gil Hyo-Wook , Lee Eun Young , Park Samel
Published: November 2023

Background: Chronic kidney disease is a significant health burden worldwide, with increasing incidence. Although several genome- wide association studies (GWAS) have investigated single nucleotide polymorphisms (SNP) associated with kidney trait, most studies were focused on European ancestry. Methods: We utilized clinical and genetic information collected from the Korean Genome and Epidemiology Study (KoGES). Results: More than five million SNPs from 58,406 participants were analyzed. After meta-GWAS, 1,360 loci associated with estimated glomerular filtration rate (eGFR) at a genome-wide significant level (p = 5 × 10–8) were identified. Among them, 399 loci were validated with at least one other biomarker (blood urea nitrogen [BUN] or eGFRcysC) and 149 loci were validated using both markers. Among them, 18 SNPs (nine known ones and nine novel ones) with 20 putative genes were found. The aggregated effect of genes estimated by MAGMA gene analysis showed that these significant genes were enriched in kidney-associated pathways, with the kidney and liver being the most enriched tissues. Conclusion: In this study, we conducted GWAS for more than 50,000 Korean individuals and identified several variants associated with kidney traits, including eGFR, BUN, and eGFRcysC. We also investigated functions of relevant genes using computational methods to define putative causal variants.
Prevalence of Helminths in Backyard Poultry in the Community of Valles Blanco, Cuba
Authors: Fimia-Duarte Rigoberto
Published: November 2023

Creole hen production is essential for the rural peasant population as a source of income and a way to guarantee food security in these communities. The objective of this study was to determine the prevalence of helminths in backyard poultry in the community of Valles Blanco, Villa Clara, Cuba. Poultry keepers in an extensive production system were visited and a semistructured interview was applied in the study setting. Twenty-six birds were analyzed out of a total population of 350, distributed in three yards, to which a dissection of the gastrointestinal tract was performed, making a cut at the esophagus level and another at the cloaca level, and the content was observed in a dark bottom container. The presence of parasitic agents in the backyard poultry population in the area studied is associated with sanitary gaps, such as scarce specialized technical assistance, lack of knowledge on the part of farmers about parasitic forms, their vectors, prevention and control. Backyard poultry showed high extensiveness and intensity of parasitic invasion by nematodes and cestodes. The main parasites found were Oxyspirura mansoni, Heterakis gallinarum, Ascaridia galli, Cestodes and Acuaria hamulosa. The results showed a prevalence of 88.46% in the backyard poultry population. It is concluded that the backyard poultry in the community under study showed high extensiveness and intensity of parasitic invasion, both by nematodes and cestodes.
Consideration of excessive water saturation of soil in the design of nail slope support
Authors:   Saint Petersburg State University of Architecture and Civil Engineering, Konyushkov V. V. , Suleymanova S. N. S. N. ,   Saint Petersburg State University of Architecture and Civil Engineering
Published: November 2023

Nail slope support has proven itself as an effective engineering protection measure, which is used to increase the stability of slopes, and involves the installation of drilling-injection ground nails together with a flexible cover system. The article considers the issue of improving the existing design methodology of this type of structure, which will include an assessment of the overall stability of the slope, an assessment of the local stability of the surface layer, considering soil moisture saturation, checking the strength of the nail on the ground and material, as well as checking the strength of the nail attachment (ground nail and steel network) on slice. To achieve this goal, there was carried out a selection of soil nailing support for the considered engineering-geological section using the Plaxis 2D PC and there was offered an analytical method for calculating slope stability. The authors also propose a method that can be used for assessing the strength characteristics of soils of the surface layer, considering excessive soil water saturation.
Enhancing heat transfer performance of automotive car radiator using camphor nanoparticles: experimental study with bibliometric analysis
Authors: Kolakoti Aditya , Setiyo Muji , Husaeni Dwi Novia Al , Nandiyanto Asep Bayu Dani
Published: November 2023

In this study, an attempt was made to investigate the heat transfer performance of a four-wheeler automotive radiator using a novel coolant system. To support this study, we also added bibliometric analysis to show the importance of this study. In the experiments, camphor nanoparticles (sizes of 511 nm) with various loadings (i.e. 2, 4, 6, and 8%) were mixed with deionized water (DW) to create a coolant. The experiments were conducted at different heat convection processes (i.e. 0.5, 1.45, and 3.7 m/s). The significant heat transfer performance parameters, such as Reynolds number (Re), Nusselt number (Nu), overall heat transfer coefficient (U), and heat transfer rate (Q), were examined. The Fourier Transform Infrared results revealed the presence of significant functional groups in the coolant system. camphor nanoparticles dispersed in DW were stable for more than 8 hours. At 70 ᵒC, the novel coolant (2% camphor nanoparticles in DW) exhibits better Re, Nu, U, and Q than that using pure DW or other loadings of nanoparticles (e.g. 4, 6, and 8%). The high percentage of camphor nanoparticles in DW restricts the fluid flow, resulting in a drop in overall heat transfer performance. Finally, low-cost, easily available, and eco-friendly camphor nanoparticles (2%) are suggested as a better choice in lieu of high-cost metallic and non-metallic nanoparticles as an additive in the coolant system.
Análisis del comportamiento y evasión en rentas de cuarta categoría en Perú 2018-2021
Authors: Chung Sanchez Kenji Alberto , Fernandez Loo Jessica Giovanna , Burgos Zavaleta Víctor Fernando Jesús
Published: November 2023

El objetivo de la presente investigación fue describir las rentas de cuarta categoría, medidas por el número de contribuyentes, y explicar su comportamiento en los últimos años y su tendencia a la posible evasión. La investigación fue descriptiva, basada en información cuantitativa del INEI, MTPE, SUNAT y BCRP con el propósito de mostrar el comportamiento de las rentas de cuarta categoría en el sector público y privado durante los años 2018 al 2021. Los ingresos recaudados por rentas de cuarta categoría, a pesar de la disminución del número de contribuyentes durante la crisis económica derivado de la pandemia, muestran altos niveles de estabilidad, crecimiento, pero muy poco control en contraste de los otros tipos de rentas. Además, se muestra que un elevado porcentaje de Recibos por honorario electrónicos emitidos por estos contribuyentes que no son bancarizados promoviendo la evasión tributaria. Losingresos por rentas de cuarta categoría dentro del contexto peruano durante los años 2018 al 2021 muestran crecimiento y estabilidad, siendo evasión en elsector público mínima debido al control del estado, pero siendo difícil de medir y controlar en el sector privado por parte de la administración tributaria debido a que la actividad económica por contribuyente no es precisa y a la creciente emisión de recibos por honorarios sin bancarización, incentivando la evasión tributaria.
Convalescent Plasma Therapy for COVID-19 with Pregnancy in Sanglah Hospital, Denpasar
Authors: Suwandari Ni Luh Ayu , Mulyantari Ni Kadek , Wirawati Ida Ayu Putri
Published: November 2023

The Coronavirus Disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO). Pregnant females are a vulnerable population to contract COVID-19. The most promising therapies for COVID-19 infection are Remdesivir and Convalescent Plasma Therapy (CPT). Convalescent plasma therapy in COVID-19 with pregnancy is rare. A 26-year-old female with 29-30 weeks pregnancy with complaints of shortness of breath and cough was referred. Physical examination showed an increase in respiratory rate. Laboratory tests showed increased WBC (leukocytosis), anemia, thrombocytosis, Neutrophil-Lymphocyte Ratio (NLR), SGOT, and C-reactive protein. The results of the RT-PCR molecular biology test showed confirmed COVID-19. In treatment, complaints worsened with a respiratory rate of 32 beats/minute and oxygen saturation of 93%. The patient was treated with CPT and showed clinical improvement. Convalescent plasma therapy in pregnancy with COVID-19 aims to prevent the binding of spike protein (S) in the virus with the ACE-2 receptor in the host. Convalescent plasma therapy should be carried out in the right conditions according to the agreed criteria. Because clinical and laboratory improvements were observed in this study after convalescent plasma therapy was administered, it can be considered as an alternative therapy in severe clinical conditions.
Suitability Analysis of Gram Staining with Blood Culture in Bacteremia
Authors: Maulida Eva Nada , Handayani Irda , Kadir Nursin Abdul
Published: November 2023

Bacteremia is a serious bloodstream infection, requiring blood culture as the gold standard for definitive diagnosis and rational therapy, but it is time-consuming. The Gram stain should be considered as an alternative test, as it is easier and faster to determine empirical antibiotic therapy in order to minimize the use of broad-spectrum antibiotics. This study aimed to analyze the suitability of Gram staining results with blood cultures in bacteremia. Cross-sectional study design from August to September 2022 at Dr. Wahidin Sudirohusodo Hospital and Labuan Baji Hospital, Makassar. The study sample used specimens from automatic positive blood culture bottles of new bacteremia patients. Gram staining and sub-culture were performed to determine the type of Gram-positive or negative bacteria. Appropriate statistical analysis was used to compare the two methods. A total of 78 research samples were obtained. The results of subculture vs. Gram staining showed Gram-positive bacteria in 45 vs. 42 samples and Gram-negative bacteria in 33 vs. 36 samples, respectively. A comparative test using the Wilcoxon test showed no significant difference for the 2 tests, p-value = 0.257 (p > 0.05). The results of the Gram diagnostic test on culture showed high sensitivity and specificity, respectively: 88.9%, and 93.9% for Gram-positive bacteria, 93.9% and 88.9% for Gram-negative bacteria. Positive Predictive Value (PPV) and Negative Predictive Value (NPV) were 95.32% and 95.32% for Gram-positive, 86.11%, and 95.23 % for Gram-negative bacteria, respectively. There is a suitability between Gram stain and automatic blood culture results with high diagnostic value. Gram staining is expected to be a guide for selecting empirical therapy based on Gram's classification until the AST test results come out.
Correlation between Neutrophil-Lymphocyte Ratio and Urea Serum in Hemodialysis Patients at Dr. Doris Sylvanus Hospital
Authors: Sambo Nafisy Apritis , Sasmithae Lia , Nugrahini Sintha
Published: November 2023

Chronic Kidney Disease (CKD) is a condition characterized by kidney damage for > 3 months, as well as structural or functional abnormalities with or without a decrease in Glomerular Filtration Rate (GFR) < 60 mL/minute/1.73. This damage leads to increased urea levels in the blood, also known as uremia, which can increase the risk of inflammation in CKD patients undergoing hemodialysis (HD). Previous studies revealed that increased urea and Neutrophil-Lymphocyte Ratio (NLR) can be used as inflammatory biomarkers to replace CRP, IL-6, and other indicators. This study aimed to determine the correlation between NLR and serum urea levels in pre- and post-HD CKD patients at Dr. Doris Sylvanus Hospital. An analytical survey method was used with a retrospective design.The process started by taking medical records of patients currently undergoing HD who were selected as respondents. The sample population consisted of 50 (70.4%) males and 21 (29.6%) females. Based on the age group, 43.7% of patients were aged 51-60. The results showed that the average NLR pre- and post-HD were 5.24±4.88 and 10.41±12.31, respectively. The average urea pre- and post-HD were 195.97±77.88 and 120.97±47.4, respectively. The bivariate analysis showed a significant weak correlation between NLR and serum urea level pre-HD (p=0.004 with r =0.338) and post-HD (p=0.039 with r =0.246) in patients.
Correlation between Serum Levels of Vaspin, BMI, and Waist Circumference on Obese and Non-Obese Subjects
Authors: Syahrir Reskiana , Nurahmi Nurahmi , Kurniawan Liong Boy
Published: November 2023

Obesity is the accumulation of excessive fat resulting from an imbalance in energy intake compared to energy used for a long period. Vaspin is secreted in adipose tissue and may exhibit compensatory responses related to obesity, insulin resistance, and type 2 diabetes mellitus. This study aimed to determine vaspin levels in obese and non-obese subjects.  An observational research design with a cross-sectional approach was used in this study. A total of 80 research subjects were included in this study. The research was conducted at the Clinical Pathology Laboratory at the Department of Clinical Pathology, Hasanuddin University Hospital in January 2022. Kolmogorov-Smirnov test was used to determine the normality of the data. Chi-Square, unpaired T-test, Mann-Whitney test, and Spearman test were used as statistical tests. This study showed a significant difference in anthropometric parameters between the obese and non-obese groups (p < 0.001). There was a significant difference in the mean levels of vaspin between the obese and non-obese groups (707.68±774.47 ng/mL vs. 510.60±460.08 ng/mL, p=0.004). There was a positive correlation between vaspin levels and waist circumference (r = 0.245, p=0.004) and between vaspin levels and BMI (r = 0.322, p=0.028). The serum levels of vaspin tended to be higher in obese subjects compared to non-obese subjects. The positive correlation between vaspin levels and BMI and waist circumference indicated that a higher BMI and/or waist circumference led to a higher vaspin level.
“New technologies” and “old values”: The function of various text and media forms in literary studies
Authors: Svensson Anette
Published: November 2023

In a society where multimodal stories (movies, TV series, and computer games) have a big influence on young people, reports show that young people demonstrate a decrease in reading habits, reading comprehension, and reading abilities. This article analyses to what extent and in what way(s) various text and media forms are used in literary studies at upper secondary level in Sweden through interviews with five teachers, who offer their experiences, ideas, and thoughts on working with various fictional texts. The results show that novels are used most frequently, that the teachers struggle with the decrease in reading habits among their students, that the students prefer and show great knowledge about films, that there is an absence of multimodal fictional texts in literary studies, and that the teachers see that neither text form nor media form has an impact on student performance.