bluuebunny/crossref_metadata_2025 huggingface dataset:
Videogames and (language) education
Authors: Koutsogiannis Dimitrios , Adampa Vasiliki
Published: July 2022

There is a productive discussion concerning the use of videogames in (literacy) education, focusing on their unique pedagogic potentials and on their interconnection with contemporary developments in textual and semiotic issues. Our main aim is to extend this discussion towards a more critical post-videogaming perspective, in the sense that videogames have to be considered as part and parcel of the contemporary, complex socio-cultural and historical context. Therefore, we focus on highlighting indicative aspects of this complexity, and we adopt concepts from the field of critical sociolinguistics, such as scales, strategies, and orders of literacy. We analyze a combination of quantitative (1.185 questionnaires) and qualitative data (6 ethnographic case studies) originating from children 11-15 years old.  Our analysis reveals that, although videogaming tends to be a common youth practice, the other important differences/inequalities permeating parenting strategies, school practices, and children’s literate identities remain unchanged, posing serious questions in terms of the promising educational use of videogames. We propose a historically sensitive perspective in order to connect videogames with schooling and especially L1 teaching.
Public Investment in Human Capital and Economic Growth in Algeria: An empirical study using ARDL approach
Authors: Ramli Mohamed , Boutayeba Faiçal , Nezai Azzeddine
Published: July 2022

The main aim of this research paper is to examine empirically the link between public investment in human capital and economic growth in Algeria over the period 1990-2017. In fact, public authorities spend annually considerable funds to make both education and health available for all citizens as they are vital elements for a better life. This political action which is well understood from social perspective should have also some economic benefits especially in terms economic growth. Scholars strongly argued the crucial importance of investing in human capital to spur growth. In this context, the current paper tends to assess the impact of public spending devoted to human capital components on economic growth in Algeria. To do so, the study used annual time series data of government expenditures on these two sectors ranged from 1990 to 2017, and employs for estimation the autoregressive distributed lag (ARDL) approach. The main finding of this paper is that there is no cointegrating relationship between these two variables in the long run. This result is in line with many previous studies in Algeria as well as in other developing countries. This basically supports the idea that spending on education and health would not inevitably lead to growth. The lessons learnt from the experience of emerging economies denote that there are a series of preliminary conditions that should be set up to make the association between public investment in human capital and growth possible. Government spending alone cannot induce economic growth if corruption prevails and resources are inefficiently allocated. Also, it is the quality of health and education that matters. In Algeria, despite of the considerable funding of education and health sectors, the quality of service offered inside schools and hospitals is still poor. Thus, increasing numbers of doctors leave the country because they believe that work conditions are not suitable. Many Patients also prefer to join foreign hospitals because they believe that local medical service is somewhat unsatisfactory. Likewise, a great number of university students choose to join foreign universities to pursue their higher studies because they consider the quality of local universities is poor. Based on this evidence, policymakers are invited to take into consideration these conditions among others in order to strengthen the impact of public investment in human capital on economic growth in the future.
Forward Higgs production at NLO using Lipatov's high energy effective action
Authors: Hentschinski Martin
Published: July 2022

We use Lipatov's high energy effective action to determine the next-to-leading order corrections to Higgs production in the forward region. As a new element we provide a proper definition of the desired next-to-leading order coefficient within the high energy effective action framework, extending a previously proposed prescription. We further propose a subtraction mechanism to achieve for this coefficient a stable cancellation of real and virtual infra-red singularities in the presence of external off-shell legs and discuss aspects related to choice of a reference scale for high energy resummation.
TMD observables in unpolarised Semi-Inclusive DIS at COMPASS
Authors: Moretti Andrea
Published: July 2022

In 2016 and 2017, the COMPASS Collaboration at CERN collected a large sample of DIS events with a longitudinally polarised 160 GeV/c muon beam scattering off a liquid hydrogen target. Part of the collected data has been analysed to extract preliminary results for the amplitudes of the modulations in the azimuthal angle of the charged hadrons and for their transverse-momentum distributions. These observables give relevant information for the study of the transverse momentum and spin structure of the nucleon. Similarly to the results obtained in COMPASS with a deuteron target, the azimuthal asymmetries exhibit interesting kinematic dependences, while the squared-transverse-momentum distributions can be described by the sum of two exponential functions.
Subnucleon fluctuations in coherent and incoherent ultra-peripheral AA collisions at LHC and RHIC with the Sartre event generator
Authors: Toll Tobias
Published: July 2022

Sartre~has been extensively used for describing photon-nuclei processes at the electron-ion collider (EIC) as well as ultra-peripheral collisions (UPC) at LHC and RHIC. Sartre is an event generator which implements the dipole model for DIS, and models the transverse geometry of the target nucleus or proton in coordinate space. It uses the Good-Walker mechanism for simulating fluctuations which contribute to the incoherent cross section for which the target breaks up after the interaction. With improved precision of UPC measurements in the last years, a detailed test of the dipole model has become possible, and Sartre's model was found lacking. In these proceedings we add subnucleon fluctuations to the nucleus and show that this is sufficient for describing the vast majority of the present measurements. We also find that for larger momentum transfers in the nucleus, which probes gluon fluctuations at higher resolution, the current complexity of the model may not suffice. Future measurements at the LHC, RHIC and especially the EIC has the potential to reveal these gluon vacuum fluctuations and glean novel insights into the self-interacting quantum field of QCD.
Drell-Yan transverse spectra at the LHC: a comparison of parton branching and analytical resummation approaches
Authors: van Kampen Aron Mees
Published: July 2022

I report on precision comparisons of theoretical predictions
for Drell-Yan (DY) transverse momentum spectra from two approaches: the analytical resummation approach based on
Collins-Soper-Sterman (CSS) formalism and the parton branching (PB) approach to the evolution of transverse momentum
dependent (TMD) parton distributions.
Gluon pseudo-distributions at short distances
Authors: Balitsky Ian , Morris Wayne , Radyushkin Anatoly
Published: July 2022

We present the results that are necessary in the ongoing lattice
calculations of the gluon parton distribution functions (PDFs) within
the pseudo-PDF approach. We identify the two-gluon correlator functions
that contain the invariant amplitude determining the gluon PDF in the
light-cone z^2 \to 0z2→0
limit, and perform one-loop calculations in the coordinate
representation in an explicitly gauge-invariant form. Ultraviolet (UV)
terms, which contain \ln (-z^2)ln(−z2)-dependence
cancel in the reduced Ioffe-time distribution (ITD), and we obtain the
matching relation between the reduced ITD and the light-cone ITD. Using
a kernel form, we get a direct connection between lattice data for the
reduced ITD and the normalized gluon PDF.
Transverse-momentum-dependent parton distribution functions for spin-1 hadrons
Authors: Kumano Shunzo , Song Qin-Tao
Published: July 2022

We show transverse-momentum-dependent parton distribution functions
(TMDs) for spin-1 hadrons including twist-3 and 4 functions by taking
the decomposition of a quark correlation function in the
Lorentz-invariant way with the conditions of Hermiticity and parity
invariance. We found 30 new TMDs in the tensor-polarized spin-1 hadron
at twists 3 and 4 in addition to 10 TMDs at twist 2. Since
time-reversal-odd terms of the collinear correlation function should
vanish after integrals over the partonic transverse momentum, we
obtained new sum rules for the time-reversal-odd structure functions,
{\int d^2 k_T g_{LT} = \int d^2 k_T h_{LL} = \int d^2 k_T h_{3LL} =0}∫d2kTgLT=∫d2kThLL=∫d2kTh3LL=0,
at twists 3 and 4. We also indicated that transverse-momentum-dependent
fragmentation functions exist in tensor-polarized spin-1 hadrons. The
TMDs can probe color degrees of freedom, so that they are valuable in
providing unique opportunities for creating interdisciplinary physics
fields such as gluon condensate, color Aharonov-Bohm effect, and color
entanglement. We also found three new collinear PDFs at twists 3 and 4,
and a twist-2 relation and a sum rule were derived in analogy to the
Wandzura-Wilczek relation and the Burkhardt-Cottingham sum rule on the
structure function {g_2}g2.
BMI COMPARISON IN DIABETIC HYPERTENSIVES VS DIABETIC NORMOTENSIVES
Authors:   Senior Resident, Department of physiology, SKIMS Medical College, Srinagar, India., S. Mudasir , N. Bhat Anjali ,   Professor, Principle, Govt. Medical College, Kathua, India., S. Sunil ,   Professor & Head, Department of physiology, Govt. Medical College, Jammu, India.
Published: July 2022

Background: Increased body fat levels are associated with an increased risk of metabolic disorders such as type 2 diabetes, high blood pressure, and dyslipidemia. Recommendations for treating obesity are currently based on BMI conditions, with variable cut-off points based on the presence or absence of obesity-related disease. In addition, many people with type 2 diabetes are either overweight or obese. Although these basic clinical ideas may be well-received by many physicians and researchers, and are thought to be easily found in medical literature, the authors are unaware of any previous reports summarizing data on the important relationship between BMI and type 2 diabetes in a broad way. Aim: To compare BMI in diabetic hypertensives and diabetic normotensives. Methods: A prospective screening study was conducted in 200 studies aged 40-60 from November 2019 to October 2020 on patients with type 2 diabetes (both old and new cases) with high blood pressure without having any complications related to diabetes and age and gender-matched sex without high blood pressure. Results: The BMI average in group 1 was 27.98 Â± 4.60 kg / mÂ² and that in group 2 was 25.73 Â± 3.02 kg / mÂ², the difference between the two groups was statistically significant (p <0.0001). The average systolic and diastolic blood pressure in Group 1 was 127.64 Â± 13.41 and 86.20 Â± 7.06 mmHg and for Group 2 blood it was 118 Â± 10.80 and 77.52 Â± 7.87 mmHg, the difference between the two groups was significant (010.0 in high numbers). Means Fasting Blood Group 1 blood sugar was 177.91 Â± 62.52 mg / dl and Group 2 blood was 197.80 Â± 74.75 mg / dl, the difference being statistically significant (p = 0.043). Conclusion: The BMI ratio in patients with diabetes and high blood pressure was significantly higher than in diabetes alone, indicating that high BMI is a risk factor for the development of macrovascular disorders and thus a sign of illness and death.
IS MY STETHOSCOPE HARMLESS? : OPERATING ROOM STETHOSCOPES UNDER MICROSCOPES
Authors:   Anesthesia and Intensive Care Unit, Mohamed V Military Training Hospital, Rabat, Morocco., Halhoul Youssef , Hammadi Hicham ,   Anesthesia and Intensive Care Unit, Mohamed V Military Training Hospital, Rabat, Morocco., Jeddab Achraf ,   Anesthesia and Intensive Care Unit, Mohamed V Military Training Hospital, Rabat, Morocco., Fakri Ahmed ,   Anesthesia and Intensive Care Unit, Mohamed V Military Training Hospital, Rabat, Morocco., Hmadate Ilyas ,   Anesthesia and Intensive Care Unit, Mohamed V Military Training Hospital, Rabat, Morocco., Eddine El Miskini Salah ,   Anesthesia and Intensive Care Unit, Mohamed V Military Training Hospital, Rabat, Morocco., Elwali Abderrahmane ,   Anesthesia and Intensive Care Unit, Mohamed V Military Training Hospital, Rabat, Morocco., Meziane Mohammed ,   Anesthesia and Intensive Care Unit, Mohamed V Military Training Hospital, Rabat, Morocco., Bensghir Mustapha ,   Anesthesia and Intensive Care Unit, Mohamed V Military Training Hospital, Rabat, Morocco., Sekhsokh Yassine ,   Research and Biosafety Laboratory, Mohamed V Military Training Hospital, Rabat, Morocco.
Published: July 2022

Medical equipment especially stethoscopes, are increasingly responsible for healthcare-associated infections. The objective of our work is to establish the prevalence of bacteria carried by stethoscopes among anesthesia doctors in the operating roomof the Mohammed V Military Teaching Hospital. This was a prospective prevalence study carried out over a period of 2 months on 10 stethoscopes showing that 90% of the stethoscopes collected were infected. The average number of CFU / membrane was estimated at 3.1x104. This number has clearly been reduced 172 times after disinfection. This study suggests that awareness and the use of hydro alcoholic solutions to disinfect stethoscopes can significantly reducebacterial carriage and infections.
RAJAMOHANA KURAVANJI
Authors:   Under the Guidance of Dr. Lalitha Santhanam, Asst Professor Vels University(VISTAS), Chennai., Mortha Daniel
Published: July 2022

This article would contain a pack of simple introductions about Giriraja Kavi, the kingdom where he was working, his litteral efficiency, other contributions, and a detailed analysis of the work RAJAMOHANA KURAVANJI.
INDUSTRIALIZED ANIMAL AGRICULTURE IS THE LEADING CAUSE OF GLOBAL WARMING LITERATURE REVIEW
Authors:   Assocaite Professor, Amity School of Architecture and Planning, Amity University, Mumbai., Sushant Jaganade Ar.
Published: July 2022

Climate change is now been witnessed all around the globe. The environmentalist was aware of this term and the consequences, yet they were not expecting it to show results in 21st century. The unprecedent rains, droughts, hurricanes, floods are happening frequently and this is making global citizen to know the causes of this occurrences. Due to this, the term climate change and global warming hit the various strata of the society. The educated and uneducated both are been made aware of the related terms through print media and social platforms as they are facing the consequences. The evidence of records through satellite images and meteorological data proves that climate change is not a myth and it is evident through the data. This research article is focused on finding out the major factor contributing to the climate change. Factors such as burning of fossil fuels, deforestation, farming, animal farming, etc. of all these factors which is the leading cause can be determined through the literature review in this paper. In this literature study it was also noticed that nobody emphasized on industrialized animal agriculture as the cause of green house gases. This study came to conclusion that the industrialized animal agriculture is the leading cause of global warming.
THE BASIC DIETARY REQUIREMENT OF DIFFERENT AGE GROUPS (AMAR) AND THE PRINCIPLES OF UNANI MEDICINE
Authors:   Assistant Professor, Department of Kulliyat, Faculty of Unani Medicine, AMU, Aligarh., Noor Huma , Nuzhat Khan Sheeba ,   Guest Teacher, Department of Kulliyat, Faculty of Unani Medicine, AMU, Aligarh.
Published: July 2022

Diet is an essential part of life without which one cannotbe able to survive. It is quite possible to survive for few days to months without having food. The quality of dietary substances has great impact on human health and the aging process. There are different age groups which require different nutritional values in their specific diet. The temperament of the dietary substances and temperament of different age groups are kept on the priority in the Unani medicine while advising certain food items in ones diet or to make it a balanced diet.Other factors like food availability, season, occupation, gender, socioeconomic status etc are also kept in mind during selection or advice of food items in ones diet. This paper will elaborate temperament of different age groups (broadly 4 age groups in Unani system of Medicne: Sinn-e-Namu, Sinn-e-Shabab, Sinn-e-Kuhulat and Sinn-e-Shaikhukhat) and diet according to their requirement.
Using the syndrome approach to the diagnosis of autism in children
Authors: Tkachuk E. A.
Published: July 2022

Autism spectrum disorders in children is a very urgent problem. Today, there is an increase in the number of children suffering from autism spectrum disorders around the world. The relevance of early diagnosis of autism spectrum disorders for timely treatment and correction is high. However, the diagnostic criteria for ASD require an assessment of certain psychomotor skills in a child, which mature much later than necessary for a timely diagnosis, so the diagnosis is made by 5-7 years. New clinical guidelines suggest that primary screening should be performed by a pediatrician. However, practice shows that in reality this does not happen. The reason for this is not only a contradiction in the diagnostic criteria, but also the current ICD-10 classification, which does not reflect the pathogenetic processes in the child's body. Despite this, new clinical guidelines recognize the role of genetic disorders and epigenetic factors in the development of autism spectrum disorders. In this regard, it is proposed to consider autism spectrum disorders as a syndrome that accompanies various genetic disorders, both chromosomal and monogenic anomalies. This approach enables early diagnosis of autism spectrum disorders, as well as the development of treatment and correction methods based on pathogenetic disorders. Currently, more than 100 genes associated with autism are known. In the above studies, it was noted that the polygenic nature of disorders in autism does not allow focusing on phenotypic features. Probably, this is the reason for the difficulties in diagnosing autism by external signs and the low efficiency of the currently known screening methods for diagnosing autism spectrum disorders. Therefore, autism spectrum disorders must be considered from the point of view of pathogenetic changes in the child's body, usually of a hereditary nature, which will allow us to offer effective methods of diagnosis, treatment and correction.
Children with diabetes and the social world: problems and opportunities (social health and educational program “Diabetes. Dances. Children”)
Authors: Motovilin O. G. , Saverskaya E. N. , Khairov R. R.
Published: July 2022

Diabetes mellitus (DM) in children has an impact on the social world of the child, changing his environment and his own role. A comprehensive approach to the treatment of diabetes in childhood involves taking into account the characteristics of a growing organism, analyzing socio-psychological factors and individual personality traits. The article analyzes the significant social spheres in which a child's relationships are built: family, non-family environment (peers and other children, educators, teachers, doctors). Special attention is paid to the negative impact of the Internet and social networks on the formation of opinions and attitudes of a child with diabetes and his parents to doctors and treatment. One of the tasks of DM therapy is to create a social situation that will contribute to the formation of personal qualities in a child that are necessary for managing the disease and maintaining psychological well-being. The tools for implementing this direction are both traditional diabetes schools and promising types of programs with the creation of groups of children involved in active joint activities: artistic, sports, dance, intellectual, etc. As an example of an innovative approach to teaching, adaptation and inclusion of children with diabetes in society, the social health and educational program “Diabetes. Dances. Children”, which has been implemented since 2020 in Moscow. The program is attended by 15 children and adolescents with diabetes (5-15 years), diabetes experience from 2 months to 10 years. The features of the program consist in the adaptation of dance and physical activities to the glycemic indices of children in dynamics; participation in the program of children, their family environment and friends; accompanying endocrinologists and clinical psychologists; conducting seminars for children and parents as part of an educational marathon; participation of children in dance competitions and festivals, video filming and various creative events.
The anthropology of the reader’s experience in the story Cancer Ward by A. I. Solzhenitsyn
Authors: Martyanova Svetlana A.
Published: July 2022

This article studies reader’s experience of A. I. Solzhenitsyn a means of characterizing the consciousness and behavior of the characters in the story Cancer Ward. Different researchers have already paid attention to the role of a book, reading, and a person reading verbal and artistic texts in the artistic world (Don Quixote by Cervantes, Eugene Onegin by A. S. Pushkin, Poor Folk by F. M. Dostoevsky, Madame Bovary by G. Flaubert); however, these works were fragmentary. The relevant aspects of 20th century literature, including Solzhenitsyn’s texts, have been studied even less.
The author of this article shows that the appeal to the reader’s experience of the characters is an essential facet of the objective world of the story Cancer Ward. The analysis focuses on the question how a book which has been read becomes a part of a character’s existential and cultural experience, evidence of either their insights, discoveries, or delusions, dead ends. The article substantiates the discussion of the book in the depiction of Solzhenitsyn’s characters from the point of view of cultural anthropology, which studies the relationship of a person with cultural tradition and society, and psychological — with its interest in forms of thinking and communication. Experiences in interpreting what Solzhenitsyn’s characters read are important not only for characterizing individual characters, but also for society as a whole. This article emphasizes that the cultural problems of the Soviet era were due to the “archaeological” type of hermeneutics, which alienated a person from the classical tradition, which is enduringly valuable for the self-determination of a person. There are two types of eventfulness in the narrative organization of the text: plot and existential. A special place in the overall picture belongs to a semi-autobiographical character — Oleg Kostoglotov, whose path from death to resurrection includes the experience of reading and comprehending reality through artistic and philosophical texts.
The methodological foundation of the work includes the approaches developed by comparative literature, intertext theory, as well as anthropological, historical, and cultural studies.
The popular song in the socio-cultural space of modern Russia: transformation of codes and meanings (based on content analysis materials)
Authors: Kargapolova Ekaterina V. , Malkova Sofia A. , Vershkova Yana I. , Glinko Oksana S.
Published: July 2022

Popular music is one of the instruments of influence on the masses, which raises the importance of tracking the direction of changes in the ideas, broadcast in popular songs. The relevance of this topic relates to the inclusion of Russia in global processes, when intercultural integration becomes one of the factors of transformation of the socio-cultural space under the influence of new rules and patterns of musical life. The purpose of this study is to analyze changes in the codes and meanings of popular songs of modern Russia. The novelty of the study is as follows. Based on the content analysis, general trends in the transformation of codes and meanings of popular songs in Russia from 1990 to 2021 are shown. The growth of listening to popular songs and comments on it was revealed, which indicates the scaling of the impact on the audience, especially on representatives of the younger generation. A decrease in the average age of performers was recorded. It is determined that the main theme of the songs is the theme of love, which is often presented in a tragic or vulgar context. Socially significant positive topics (patriotism, politics, childhood, youth, family) occur in fragments or in isolated cases. An increase in the number of lines of songs with a constant number of words since 2001 has been revealed with a drop in the share of disclosure of the theme of songs, which indicates the destruction of speech and general cultural norms, the desire of performers to “hype”, the growth of popularity, commercial benefits, and not to convey the meaning of the lyrics. The specifics of the song genre in Russia are shown for three periods: 1990-2000, 2001-2010, and 2011-2021. The “roaring”, “heavy-hearted” nineties with a sense of the breakdown of the social system, habitual personal relationships and social ties are replaced by pop “zero” with expectations of positive changes, freedom. The period since 2011 is characterized by a wide variety of stylistic trends and not just significant banality and mediocrity of the text, but also the glorification and justification of deviant behavior, the predominance of pessimistic and sexualized mood, aggression, turning into an insult. This leads to the fact that the song, as a “public singing” that unites and elevates people, becomes dysfunctional, destructive, destroying the personality (especially the emerging one), social ties, the social system, the socio-cultural space of the country as a space of norms and rules. The direction of further research is related to the development of methodological recommendations on the criteria for censoring the musical space in order to restore the speech norm and the traditional Russian system of values.
Social health as a category of sociology
Authors: Morev Mikhail V.
Published: July 2022

The growing nature of global challenges actualizes the study of a range of issues related to the preservation and strengthening of public health as the main resource for competitiveness and national security. Various historical stages in the development of world civilization were characterized by the presence of a specific set of factors that actualize the theoretical understanding and empirical knowledge of certain elements of public health, which led to the realization of the complexity and multidimensionality of this category. The modern stage is characterized by conditions that bring to the fore the study of issues related to mental, spiritual, moral, social health, while the latter today seems to be the most in need of scientific reflection. The subject of this article is social health as one of the many elements of the structure of public health. The article is predominantly theoretical; its goal is to contribute to the discussion about the essence of the category “social health” and, accordingly, about the most effective approaches to its empirical measurement. An attempt was made to theoretically substantiate the relevance of scientific and practical understanding of the category of “social health” in the discourse of sociological concepts (anomia, “trauma” etc.), which significantly increases the practical significance of its study in terms of preventing negative trends not only in the field of protecting and strengthening public health but also in broader aspects of social development. Based on the results of the study, the author’s definition of social health is formulated, the dominant role of the sociological component in the interpretation and study of this phenomenon is substantiated. Attention is drawn to the importance of the operationalization of the concept of “social health”; on the practical significance of its empirical dimension, which is due to the specific nature of the processes of socio-cultural transformation of the Russian and global community as a whole, and, as a result, the need to search for new complex indicators and indicators that can represent their dynamics and current state representatively.
The discrete charm of apartheid: the reverse side of narcissistic culture
Authors: Orekhovsky Petr A. , Razumov Vladimir I.
Published: July 2022

Since the French Revolution of 1789 the tendency for social equality had been enhanced. Egalitarian movements become dominant in the 19th -20th centuries, vividly manifesting in the revolutions in Russia, China, Mexico, and in the national liberation movements. The only important exception, the system of apartheid in South Africa, where social discrimination was based on racial segregation, opposed that tendency. In the 21st century, apartheid based on a “biological” racial attribute officially ceased to exist, but if the “race” was considered as social signs according to G. Le Bon and other social thinkers of the 19th century, then, oddly enough, apartheid not only persisted, but gradually intensified. The subdivision of people into representatives of “higher” and “lower” categories took place not only within the caste system that persisted in relatively poor India, but also in rich countries with their sophisticated legal regime, dividing people into “citizens” and “non-citizens”, “labor migrants” and holders of “residence permit”. According to the authors, apartheid has organically integrated into the narcissistic culture which is specific for postmodernism and has fixed in various rhetorical, legal, and economic practices. At the same time, apartheid remains a taboo concept, but in many segments of public life, interested actors are seeking to give it a legal form. The subject matter of apartheid is rapidly updated in the second or third decades of the 21st century. The events of the past two years have awakened the interest in the theme of apartheid, demonstrating its ability to adapt to the social changes in the environment. None of infectious disease has caused such massive social segregation as the COVID-19. In line with the development of narcissism, the inversion of racial relations are explained, when the roles and social positions of the black and white people are reversed. At the same time, the former should feel guilty for the exploitation of the former for centuries in Europe and America.
Telomere Length as a Marker of Biological Aging: A Critical Review
of Recent Literature
Authors: Daios Stylianos , Anogeianaki Antonia , Kaiafa Georgia , Kontana Anastasia , Veneti Stavroula , Gogou Christiana , Karlafti Eleni , Pilalas Dimitrios , Kanellos Ilias , Savopoulos Christos
Published: July 2022

Introduction:

Aging is characterized as a syndrome of deleterious, progressive, universal, and irreversible function changes affecting every structural and functional aspect of the organism and accompanied by a generalized increase in mortality. Although a substantial number of candidates for biomarkers of aging have been proposed, none has been validated or universally accepted. Human telomeres constitute hexameric repetitive DNA sequence nucleoprotein complexes that cap chromosome ends, regulating gene expression and modulating stress-related pathways. Telomere length (TL) shortening is observed both in cellular senescence and advanced age, leading to the investigation of TL as a biomarker for aging and a risk factor indicator for the development and progression of the most common age-related diseases.

Objective:

The present review underlines the connection between TL and the pathophysiology of the diseases associated with telomere attrition.

Methods:

We performed a structured search of the PubMed database for peer-reviewed research of the literature regarding leukocyte TL and cardiovascular diseases (CVD), more specifically stroke and heart disease, and focused on the relevant articles published during the last 5 years. We also applied Hill’s criteria of causation to strengthen this association.

Result:

We analyzed the recent literature regarding TL length, stroke, and CVD. Although approximately one-third of the available studies support the connection, the results of different studies seem to be rather conflicting as a result of different study designs, divergent methods of TL determination, small study samples, and patient population heterogeneity. After applying Hill’s criteria, we can observe that the literature conforms to them weakly, with chronology being the only Hill criterion of causality that probably cannot be contested.

Conclusion:

The present review attempted to examine the purported relation between leukocyte TL and age-related diseases such as CVD and more specific stroke and heart disease in view of the best established, comprehensive, medical and epidemiological criteria that have characterized the focused recent relevant research. Although several recommendations have been made that may contribute significantly to the field, a call for novel technical approaches and studies is mandatory to further elucidate the possible association.
Therapeutic Potential of P2X7 Purinergic Receptor Modulation in the Main Organs
Affected by the COVID-19 Cytokine Storm
Authors: Batista Simões Júlia Leão , Sobierai Leilane Dayane , Pereira Stefany Maciel , Rodrigues dos Santos Miriam Vitória , Bagatini Margarete Dulce
Published: July 2022

Defined by the World Health Organization as a global public health pandemic, coronavirus 2019 (COVID-19) has a global impact and the death of thousands of people. The “severe acute respiratory syndrome coronavirus 2” virus (SARS-CoV-2) is the etiologic agent of this disease, which uses the angiotensin-converting enzyme receptor 2 (ACE2) to infect the body, so any organ that expresses the gene ACE2 is a possible target for the new coronavirus. In addition, in severe cases of COVID-19, a cytokine storm occurs, which triggers widespread systemic inflammation due to the uncontrolled release of proinflammatory cytokines. In this perspective, the modulation of purinergic receptors are highlighted in the literature as a possible therapy, considering its application in other viral infections and systemic inflammation. Therefore, the objective of this review is to gather information on the modulation of the P2X7 receptor in the main organs directly affected by the virus and by the cytokine storm: heart, brain, lung, liver and kidneys. Thus, demonstrating possible therapies for reducing inflammation, as well as reducing the level of morbidity and mortality of COVID-19.
Analysis of the Molecular Mechanism of Huangqi Herb Treating COVID-
19 with Myocardial Injury by Pharmacological Tools, Programming Software
and Molecular Docking
Authors: Zhou Yan , Chu Yuguang , Shi Jingjing , Hu Yuanhui
Published: July 2022

Background:

Huangqi with the capacity to resist virus and preserve myocardium is a
potential herb for treating patients with COVID-19 and related myocardial injury.

Method:

We applied network pharmacology method and programming software including R and
Perl to explore the probable mechanism of Huangqi fighting against the disease. Ingredients and
target gene names of Huangqi were obtained from TCMSP database. Disease-associated genes
were mined by searching GeneCards database. Venny online software was applied to draw Venn
diagram of intersection genes. Cytoscape software was used to set up the network of disease, drug,
compounds and targets. STRING database was applied to set up protein protein interaction (PPI)
network. With intersection genes imported into WEBGESALT database, gene ontology (GO)
analysis was completed. An R script basing on Kyoto Encyclopedia of Genes and Genomes
(KEGG) database was applied to obtain KEGG pathways. Finally, we used AutoDockTools 1.5.6
software for molecular docking and PyMOL to visualize the docking details.

Results:

We obtained 20 active components and 18 potential target genes to construct a network,
and found out quercetin and kaempferol were core ingredients. Key targets included EGFR,
MAPK8, IL6, CASP3, RELA and PPARG. Huangqi showed its potential to reduce inflammatory
response to prevent cytokine storm by inhibiting EGFR, IL6 and MAPK and protect myocardium
by inhibiting apoptosis and oxidant stress. Huangqi may also work by adjusting ubiquitin and regulating
multiple viral pathways.

Conclusions:

Huangqi may play a therapeutic role in treating COVID-19 with myocardial injury
by the effects of resisting virus and protecting myocardium concurrently.
Ferroptosis Inhibitors as New Therapeutic Insights into Radiation-Induced Heart Disease
Authors: Shaghaghi Zahra , Farzipour Soghra , Jalali Fatemeh , Alvandi Maryam
Published: July 2022

Radiation-induced heart disease (RIHD) is a significant cause of morbidity in breast
and other mediastinal cancers. The many molecular and cellular patho-mechanisms that have a
role in RIHD are not completely understood. Endothelial injury, oxidative stress, and inflammation,
as well as endoplasmic reticulum and mitochondrial damage, are considered the primary
causes of RIHD. Ferroptosis is a newly discovered type of cell death that results from irondependent
lipid peroxide accumulation. As ferroptosis plays an important role in the
pathogenesis of cardiovascular diseases, it seems that it has a significant effect on RIHD. It was
recently shown that ionizing radiation (IR) generates severe ferroptosis, which is a critical component
of Radiotherapy-mediated normal cell toxicity. These findings support the use of a ferroptosis
inhibitor to reduce RIHD. In this perspective review, we summarize the role of
ferroptosis in pathogens of cardiovascular disease and radiation toxicity, and we will introduce
ferroptosis inhibitors as a new strategy to prevent or reduce RIHD.
The Relationship Between Incidence of Depression After Myocardial Infarction (MI)
Authors: Gheini Alireza , Pooria Ali , Pourya Afsoun , Farokhi Ermia
Published: July 2022

Objective:

Depression is predicted to be the leading cause of mortality and morbidities in the next few years. Its association with cardiovascular diseases is well-established from various researches. The aim of this study is to evaluate the incidence of depression of co-morbid psychiatric disorders among patients with a recent history of myocardial infarction (MI).

Methods:

In this retrospective study, patients with a history of myocardial infarction marked by electrocardiographic (ECG) and enzymatic findings referred to our psychiatric center were included. The MMPI questionnaire was used to evaluate the prevalence of depression along with other psychiatric disorders. SPSS v18 was used to evaluate the data recorded and analyzed from these questionnaires.

Results:

Of 50 patients studied, the prevalence of depression is the greatest (63%) in patients with anterior septal MI. Furthermore, 26% of women and 24% of men with depression and hysteria were the common comorbidity reported. To it, 15 patients aged 60-69 years had post-MI depression.

Conclusion:

Our study reports an increased incidence of post-MI depression in the general targeted population. Further investigation and therapeutic measures can decrease future repercussions and the incidence of other cardiovascular events, including recurrent MI.
Возможность построения модульной системы квантового распределения ключей в атмосфере
Authors: Боев А.А. , Воробей С.С. , Казанцев С.Ю. , Керносов М.Ю. , Колесников О.В. , Кузнецов С.Н. , Миронов Ю.Б. , Паршин А.А. , Рудавин Н.В.
Published: July 2022

The possibility of quantum key distribution in the atmosphere has been experimentally demonstrated by coupling commercially available quantum key distribution units designed for fiber-optic communication lines with atmospheric optical communication terminals. For distances up to 3100m, data on losses in a quantum channel on an optical path were obtained and the influence of systems for intelligent adjustment of atmospheric communication terminals on the synchronization system of quantum communication blocks was studied. It has been established that failures of synchronization systems in the case of quantum key distribution in the atmosphere at distances greater than 10m are due to the peculiarities of the algorithm implemented in the quantum communication unit.
Сверхвысокочастотные диоды Шоттки на основе одиночных нитевидных нанокристаллов GaN
Authors: Шугуров К.Ю. , Можаров А.М. , Сапунов Г.А. , Фёдоров В.В. , Моисеев Э.И. , Блохин С.А. , Кузьменков А.Г. , Мухин И.С.
Published: July 2022

A series of Schottky diodes based on single GaN nanowires has been fabricated. Based on the data of small-signal frequency analysis (parameter S21) of diode structures at various bias voltages, the parameters of the corresponding equivalent electrical circuit were determined. It is shown that the cutoff frequency of the fabricated diodes reaches 27.5 GHz.
Биоимпедансный анализ состояния поверхностных тканей пациента
Authors: Рыбянец А.Н. , Швецов И.А. , Швецова Н.А. , Резниченко А.Н. , Колпачева Н.А.
Published: July 2022

A new method for analyzing physiological conditions of the patient's superficial tissues in vivo is proposed. Precision measurements of the complex electrical resistance were performed using the bioimpedance spectroscopy method. The design of a diagnostic module for complex non-invasive diagnostics of the physiological condition and processes in the surface tissues of a patient has been developed. An experimental verification of the developed method of bioimpedance spectroscopy was carried out on reference solutions and patient's superficial tissues in-vivo. A biophysical interpretation of the obtained results is proposed.
Система температурного контроля электромагнитной системы токамака Глобус-М2
Authors: Варфоломеев В.И. , Женишек Е.Ю. , Лупин А.В. , Минаев В.Б. , Сахаров Н.В. , Бабарицкий П.А.
Published: July 2022

The temperature control system used for monitoring the thermal regime of operation of the electromagnetic system of the Globus-M2 tokamak is described. The system is a hardware-software complex built on the Arduino platform based on microcontrollers of the AVR family. The developed graphical interface continuously reflects the temperature at the controlled points and signals when it goes beyond the specified range. Automatic saving of measurement results by controlled events is provided.
Collaborative Practices in Early Childhood Intervention: the case for explicitly striving for maximal participation of families
Authors: Ribeiro Lage Carla , Snider Jacqui
Published: July 2022

Early Childhood Intervention aims to empower parents and children to become confident and competent in independently finding solutions to everyday life challenges. Therapists have only the best intentions in their practice; however, in their eagerness to help, they may be unknowingly disempowering parents when taking ownership of the intervention. The purpose of this opinion paper is to encourage and inspire therapists to pause, reflect, and reconsider the significance of parent-therapist partnerships and the use of a coach approach for implementing Family-Centred Best Practice. Based on clinical and research experiences in Early Childhood Intervention, the authors believe that therapists need to further develop communication and interpersonal skills so that they can empower parents in the same way they empower children. When therapists are trained to implement collaborative practices, they may feel less pressure to have all the answers and be primarily responsible for supporting children's development and functioning. Collaborative practices such as coaching can help therapists establish a respectful, equitable, and complementary partnership with parents, transforming “power over” relationships into “power with” relationships. This change can be more rewarding and satisfying for everyone involved. Providing best practice interventions often requires therapists to constantly focus on their therapeutic expertise. Yet, the effectiveness of interventions for children and their families can also be significantly improved if therapists refine how they deliver their services. Parents play a key role in the successful intervention of their children; therefore, to achieve sustainable long-term therapy goals, it is necessary to understand how to communicate with, relate to, and coach parents effectively.
Virtual ER, a Serious Game for Interprofessional Education to Enhance Teamwork in Medical and Nursing Undergraduates: Development and Evaluation Study
Authors: Wong Janet Yuen-Ha , Ko Joanna , Nam Sujin , Kwok Tyrone , Lam Sheila , Cheuk Jessica , Chan Maggie , Lam Veronica , Wong Gordon T C , Ng Zoe L H , Wai Abraham Ka-Chung
Published: July 2022

Background

Engaging students in interprofessional education for higher order thinking and collaborative problem-solving skills is challenging. This study reports the development of Virtual ER, a serious game played on a virtual platform, and how it can be an innovative way for delivering interprofessional education to medical and nursing undergraduates.

Objective

We report the development of a serious online game, Virtual ER, and evaluate its effect on teamwork enhancement and clinical competence. We also explore if Virtual ER can be an effective pedagogical tool to engage medical and nursing students with different learning styles.

Methods

Virtual ER is a custom-made, learning outcome–driven, case-based web app. We developed a game performance scoring system with specific mechanisms to enhance serious gaming elements. Sixty-two students were recruited from our medical and nursing programs. They played the games in teams of 4 or 5, followed by an instructor-led debriefing for concept consolidation. Teamwork attitudes, as measured by the Human Factors Attitude Survey, were compared before and after the game. Learning style was measured with a modified Honey and Mumford learning style questionnaire.

Results

Students were satisfied with Virtual ER (mean satisfaction score 5.44, SD 0.95, of a possible 7). Overall, Virtual ER enhanced teamwork attitude by 3.02 points (95% CI 1.15-4.88, P=.002). Students with higher scores as activists (estimate 9.09, 95% CI 5.17-13.02, P<.001) and pragmatists (estimate 5.69, 95% CI 1.18-10.20, P=.01) had a significantly higher degree of teamwork attitude enhancement, while students with higher scores as theorists and reflectors did not demonstrate significant changes. However, there was no difference in game performance scores between students with different learning styles.

Conclusions

There was considerable teamwork enhancement after playing Virtual ER for interprofessional education, in particular for students who had activist or pragmatist learning styles. Serious online games have potential in interprofessional education for the development of 21st century life skills. Our findings also suggest that Virtual ER for interprofessional education delivery could be expanded locally and globally.