bluuebunny/crossref_metadata_2025 huggingface dataset:
Bayesian Causal Network for Discrete Variables
Authors: Wang Jing , Zhou Jinglin , Chen Xiaolu
Published: January 2022

Ensuring the safety of industrial systems requires not only detecting the faults, but also locating them so that they can be eliminated. The previous chapters have discussed the fault detection and identification methods. Fault traceability is also an important issue in industrial system. This chapter and Chap. 10.1007/978-981-16-8044-1_14 aim at the fault inference and root tracking based on the probabilistic graphical model. This model explores the internal linkages of system variables quantitatively and qualitatively, so it avoids the bottleneck of multivariate statistical model without clear mechanism. The exacted features or principle components of multivariate statistical model are linear or nonlinear combinations of system variables and have not any physical meaning. So the multivariate statistical model is good at fault detection and identification, but not at fault root tracking.
Multivariate Statistics in Single Observation Space
Authors: Wang Jing , Zhou Jinglin , Chen Xiaolu
Published: January 2022

The observation data collected from continuous industrial processes usually have two main categories: process data and quality data, and the corresponding industrial data analysis is mainly for the two types of data based on the multivariate statistical techniques.
Soft-Transition Sub-PCA Monitoring of Batch Processes
Authors: Wang Jing , Zhou Jinglin , Chen Xiaolu
Published: January 2022

Batch or semi-batch processes have been utilized to produce high-value-added products in the biological, food, semi-conductor industries. Batch process, such as fermentation, polymerization, and pharmacy, is highly sensitive to the abnormal changes in operating condition. Monitoring of such processes is extremely important in order to get higher productivity. However, it is more difficult to develop an exact monitoring model of batch processes than that of continuous processes, due to the common natures of batch process: non-steady, time-varying, finite duration, and nonlinear behaviors. The lack of exact monitoring model in most batch processes leads that an operator cannot identify the faults when they occurred. Therefore, effective techniques for monitoring batch process exactly are necessary in order to remind the operator to take some corrective actions before the situation becomes more dangerous.
Statistics Decomposition and Monitoring in Original Variable Space
Authors: Wang Jing , Zhou Jinglin , Chen Xiaolu
Published: January 2022

The traditional process monitoring method first projects the measured process data into the principle component subspace (PCS) and the residual subspace (RS), then calculates $$\mathrm T^2$$

T
2

and $$\mathrm SPE$$

S
P
E

statistics to detect the abnormality. However, the abnormality by these two statistics are detected from the principle components of the process. Principle components actually have no specific physical meaning, and do not contribute directly to identify the fault variable and its root cause. Researchers have proposed many methods to identify the fault variable accurately based on the projection space. The most popular is contribution plot which measures the contribution of each process variable to the principal element (Wang et al. 2017; Luo et al. 2017; Liu and Chen 2014). Moreover, in order to determine the control limits of the two statistics, their probability distributions should be estimated or assumed as specific one. The fault identification by statistics is not intuitive enough to directly reflect the role and trend of each variable when the process changes.
Einfluss der COVID-19-Pandemie auf die physiotherapeutische und ärztliche Nachsorge nach Rekonstruktionen des vorderen Kreuzbandes
Authors: Bartek Benjamin , Jung Tobias , Schwiedernoch Antonia , Perka Carsten , Palmowski Yannick
Published: January 2022

Hintergrund

Ziel der Studie war es, den Einfluss der COVID-19-Pandemie auf die physiotherapeutische und ärztliche Nachsorge nach Rekonstruktion des vorderen Kreuzbandes (VKB) zu untersuchen.

Methoden

Insgesamt wurden 116 Patienten (72 Männer und 44 Frauen) eingeschlossen, die zwischen September 2019 und Dezember 2020 eine Rekonstruktion des VKB erhalten hatten. Die Patienten wurden in eine 2019 vor der COVID-19(„coronavirus disease“ 2019)-Pandemie operierte Patientengruppe sowie eine 2020 operierte, von der COVID-19-Pandemie unmittelbar betroffene Patientengruppe eingeteilt. Anhand eines standardisierten Fragebogens wurden die Auswirkungen der Pandemie auf die ärztliche und physiotherapeutische Nachsorge sowie auf die Dauer der postoperativen Arbeitsunfähigkeit erhoben. Ergänzend erfolgte eine Auswertung des Bewegungsumfanges des operierten Knies 3 Monate postoperativ.

Ergebnisse

Es zeigte sich bei den 2020 operierten Patienten eine deutliche Tendenz zu einem höheren Anteil an Streckdefiziten ≥ 5° (18,8 % vs. 4,3 %, p = 0,097) oder einer maximalen Beugefähigkeit von < 120° (23,3 % vs. 10 %, p = 0,197) 3 Monate postoperativ, die allerdings nicht signifikant war. In der physiotherapeutischen und ärztlichen Nachsorge berichteten die 2020 operierten Patienten von signifikant längeren Wartezeiten auf Termine, späteren Zeitpunkten des ersten postoperativen Termins, einer höheren Anzahl vergeblicher Terminanfragen sowie einer höheren Anzahl abgesagter Termine. 34,9 % der 2020 operierten Patienten gaben an, die Dauer ihrer postoperativen Arbeitsunfähigkeit durch die Möglichkeiten zur Arbeit im Homeoffice verkürzt haben zu können. Pandemiebedingte alternative Behandlungsangebote wurden den Patienten von 13,3 % der Physiotherapeuten sowie 12,2 % der Ärzte angeboten.

Schlussfolgerung

Obwohl die physiotherapeutische und ärztliche Behandlung von keinem „Lockdown“ betroffen war, kam es aufgrund der Pandemie zu signifikanten Einschränkungen, welche sich auch in einer deutlichen Tendenz zu schlechteren klinischen Ergebnissen niederschlagen. Es besteht daher Bedarf an einem weiteren Ausbau alternativer Therapieoptionen, die bislang nur von 12–13 % der Praxen zur Verfügung gestellt werden und mutmaßlich auch für andere Erkrankungen von ähnlicher Bedeutung sind.
The social and ethical impacts of artificial intelligence in agriculture: mapping the agricultural AI literature
Authors: Ryan Mark
Published: January 2022

This paper will examine the social and ethical impacts of using artificial intelligence (AI) in the agricultural sector. It will identify what are some of the most prevalent challenges and impacts identified in the literature, how this correlates with those discussed in the domain of AI ethics, and are being implemented into AI ethics guidelines. This will be achieved by examining published articles and conference proceedings that focus on societal or ethical impacts of AI in the agri-food sector, through a thematic analysis of the literature. The thematic analysis will be divided based on the classifications outlined through 11 overarching principles, from an established lexicon (transparency, justice and fairness, non-maleficence, responsibility, privacy, beneficence, freedom and autonomy, trust, dignity, sustainability, and solidarity). While research on AI agriculture is still relatively new, this paper aims to map the debate and illustrate what the literature says in the context of social and ethical impacts. It aim is to analyse these impacts, based on these 11 principles. This research will contrast which impacts are not being discussed in agricultural AI and which issues are not being discussed in AI ethics guidelines, but which are discussed in relation to agricultural AI. The aim of this is to identify gaps within the agricultural literature, and gaps in AI ethics guidelines, that may need to be addressed.
Multi-objective Bayesian topology optimization of a lattice-structured heat sink in natural convection
Authors: Shimoyama Koji , Komiya Atsuki
Published: January 2022

Additive manufacturing (AM) has an affinity with topology optimization to think of various designs with complex structures. Hence, this paper aims to optimize the design of a lattice-structured heat sink, which can be manufactured by AM. The design objectives are to maximize the thermal performance of convective heat transfer in natural convection simulated by computational fluid dynamics (CFD) and to minimize the material cost required for AM process at the same time. The lattice structure is represented as a node/edge system via graph theory with a moderate number of design variables. Bayesian optimization, which employs the non-dominated sorting genetic algorithm II and the Kriging surrogate model, is conducted to search for better designs with the minimum CFD cost. The present topology optimization successfully finds better lattice-structured heat sink designs than a reference fin-structured design regarding thermal performance and material cost. Also, several optimized lattice-structured designs outperform reference pin-fin-structured designs regarding thermal performance though the pin-fin structure is still advantageous for a material cost-oriented design. This paper also discusses the flow mechanism observed in the heat sink to explain how the optimized heat sink structure satisfies the competing design objectives simultaneously.
Uniform Estimates in Periodic Homogenization of Fully Nonlinear Elliptic Equations
Authors: Kim Sunghan , Lee Ki-Ahm
Published: January 2022

This article is concerned with uniform $$C^{1,\alpha }$$

C

1
,
α

and $$C^{1,1}$$

C

1
,
1

estimates in periodic homogenization of fully nonlinear elliptic equations. The analysis is based on the compactness method, which involves linearization of the operator at each approximation step. Due to the nonlinearity of the equations, the linearized operators involve the Hessian of correctors, which appear in the previous step. The involvement of the Hessian of the correctors deteriorates the regularity of the linearized operator, and sometimes even changes its oscillating pattern. These issues are resolved with new approximation techniques, which yield a precise decomposition of the regular part and the irregular part of the homogenization process, along with a uniform control of the Hessian of the correctors in an intermediate level. The approximation techniques are even new in the context of linear equations. Our argument can be applied not only to concave operators, but also to certain class of non-concave operators.
Approximate Recovery and Relative Entropy I: General von Neumann Subalgebras
Authors: Faulkner Thomas , Hollands Stefan , Swingle Brian , Wang Yixu
Published: January 2022

We prove the existence of a universal recovery channel that approximately recovers states on a von Neumann subalgebra when the change in relative entropy, with respect to a fixed reference state, is small. Our result is a generalization of previous results that applied to type-I von Neumann algebras by Junge at al. [arXiv:1509.07127]. We broadly follow their proof strategy but consider here arbitrary von Neumann algebras, where qualitatively new issues arise. Our results hinge on the construction of certain analytic vectors and computations/estimations of their Araki–Masuda $$L_p$$

L
p

norms. We comment on applications to the quantum null energy condition.
Cortical abnormalities of synaptic vesicle protein 2A in focal cortical dysplasia type II identified in vivo with 18F-SynVesT-1 positron emission tomography imaging
Authors: Tang Yongxiang , Yu Jie , Zhou Ming , Li Jian , Long Tingting , Li Yulai , Feng Li , Chen Dengming , Yang Zhiquan , Huang Yiyun , Hu Shuo
Published: January 2022

Purpose

The loss of synaptic vesicle glycoprotein 2A (SV2A) is well established as the major correlate of epileptogenesis in focal cortical dysplasia type II (FCD II), but this has not been directly tested in vivo. In this positron emission tomography (PET) study with the new tracer 18F-SynVesT-1, we evaluated SV2A abnormalities in patients with FCD II and compared the pattern to 18F-fluorodeoxyglucose (18F-FDG).

Methods

Sixteen patients with proven FCD II and 16 healthy controls were recruited. All FCD II patients underwent magnetic resonance imaging (MRI) and static PET imaging with both 18F-SynVesT-1 and 18F-FDG, while the controls underwent MRI and PET with only 18F-SynVesT-1. Visual assessment of PET images was undertaken. The standardized uptake values (SUVs) of 18F-SynVesT-1 were computed for regions of interest (ROIs), along with SUV ratio (SUVr) between ROI and centrum semiovale (white matter). Asymmetry indices (AIs) were analyzed between the lesion and the contralateral hemisphere for intersubject comparisons.

Results

Lesions in the brains of FCD II patients had significantly reduced 18F-SynVesT-1 uptake compared with contralateral regions, and brains of the controls. 18F-SynVesT-1 PET indicated low lesion uptake in 14 patients (87.5%), corresponding to hypometabolism detected by 18F-FDG PET, with higher accuracy for lesion localization than MRI (43.8%) (P < 0.05). AI analyses demonstrated that in the lesions, SUVr for each of the radiotracers were not significantly different (P > 0.05), and 18F-SynVesT-1 SUVr correlated with that of 18F-FDG across subjects (R2 = 0.41, P = 0.008). Subsequent visual ratings indicated that 18F-SynVesT-1 uptake had a more restricted pattern of reduction than 18F-FDG uptake in FCD II lesions (P < 0.05).

Conclusion

SV2A PET with 18F-SynVesT-1 shows a higher accuracy for the localization of FCD II lesions than MRI and a more restricted pattern of abnormality than 18F-FDG PET.
PlantRep: a database of plant repetitive elements
Authors: Luo Xizhi , Chen Shiyu , Zhang Yu
Published: January 2022

Key message

We re-annotated repeats of 459 plant genomes and released a new database: PlantRep (http://www.plantrep.cn/). PlantRep sheds lights of repeat evolution and provides fundamental data for deep exploration of genome.
The effect of gadolinium-based contrast-agents on automated brain atrophy measurements by FreeSurfer in patients with multiple sclerosis
Authors: Lie Ingrid Anne , Kerklingh Emma , Wesnes Kristin , van Nederpelt David R. , Brouwer Iman , Torkildsen Øivind , Myhr Kjell-Morten , Barkhof Frederik , Bø Lars , Vrenken Hugo
Published: January 2022

Objective

To determine whether reliable brain atrophy measures can be obtained from post-contrast 3D T1-weighted images in patients with multiple sclerosis (MS) using FreeSurfer.

Methods

Twenty-two patients with MS were included, in which 3D T1-weighted MR images were obtained during the same scanner visit, with the same acquisition protocol, before and after administration of gadolinium-based contrast agents (GBCAs). Two FreeSurfer versions (v.6.0.1 and v.7.1.1.) were applied to calculate grey matter (GM) and white matter (WM) volumes and global and regional cortical thickness. The consistency between measures obtained in pre- and post-contrast images was assessed by intra-class correlation coefficient (ICC), the difference was investigated by paired t-tests, and the mean percentage increase or decrease was calculated for total WM and GM matter volume, total deep GM and thalamus volume, and mean cortical thickness.

Results

Good to excellent reliability was found between all investigated measures, with ICC ranging from 0.926 to 0.996, all p values < 0.001. GM volumes and cortical thickness measurements were significantly higher in post-contrast images by 3.1 to 17.4%, while total WM volume decreased significantly by 1.7% (all p values < 0.001).

Conclusion

The consistency between values obtained from pre- and post-contrast images was excellent, suggesting it may be possible to extract reliable brain atrophy measurements from T1-weighted images acquired after administration of GBCAs, using FreeSurfer. However, absolute values were systematically different between pre- and post-contrast images, meaning that such images should not be compared directly. Potential systematic effects, possibly dependent on GBCA dose or the delay time after contrast injection, should be investigated.

Trial registration

Clinical trials.gov. identifier: NCT00360906.

Key Points

• The influence of gadolinium-based contrast agents (GBCAs) on atrophy measurements is still largely unknown and challenges the use of a considerable source of historical and prospective real-world data.

• In 22 patients with multiple sclerosis, the consistency between brain atrophy measurements obtained from pre- and post-contrast images was excellent, suggesting it may be possible to extract reliable atrophy measurements in T1-weighted images acquired after administration of GBCAs, using FreeSurfer.

• Absolute values were systematically different between pre- and post-contrast images, meaning that such images should not be compared directly, and measurements extracted from certain regions (e.g., the temporal pole) should be interpreted with caution.
Revised D-A-CH reference values for the intake of biotin
Authors: Jungert Alexandra , Ellinger Sabine , Watzl Bernhard , Richter Margrit ,   the German Nutrition Society (DGE)
Published: January 2022

Purpose

The reference values for biotin intake for Germany, Austria and Switzerland lead back to a report in 2000. Following a timely update process, they were revised in 2020.

Methods

For infants aged 0 to < 4 months, adequate biotin supply via human milk was assumed and in consequence the reference value reflects the amount of biotin delivered by human milk. For infants aged 4 to < 12 months, biotin intake was extrapolated from the reference value for younger infants. Due to missing data on average requirement, the reference values for biotin intake for children, adolescents and adults were derived based on observed intake levels. The reference value for lactating women considered in addition biotin losses via human milk.

Results

The reference value for biotin intake for infants aged 0 to < 4 months was set at 4 µg/day and for infants aged 4 to < 12 months at 6 µg/day. In children and adolescents, the reference values for biotin intake ranged from 20 µg/day in children 1 to < 4 years to 40 µg/day in youths 15 to < 19 years. For adults including pregnant women, 40 µg/day was derived as reference value for biotin intake. For lactating women, this value was set at 45 µg/day.

Conclusions

As deficiency symptoms of biotin do not occur with a usual mixed diet and the average requirement cannot be determined, reference values for an adequate biotin intake for populations from Germany, Austria and Switzerland were derived from biotin intake levels assessed in population-based nutrition surveys.
Strain and interface energy of ellipsoidal inclusions subjected to volumetric eigenstrains: shape factors
Authors: Böhm H. J. , Zickler G. A. , Fischer F. D. , Svoboda J.
Published: January 2022

Thermodynamic modeling of the development of non-spherical inclusions as precipitates in alloys is an important topic in computational materials science. The precipitates may have markedly different properties compared to the matrix. Both the elastic contrast and the misfit eigenstrain may yield a remarkable generation of elastic strain energy which immediately influences the kinetics of the developing precipitates. The relevant thermodynamic framework has been mostly based on spherical precipitates. However, the shapes of actual particles are often not spherical. The energetics of such precipitates can be met by adapting the spherical energy terms with shape factors. The well-established Eshelby framework is used to evaluate the elastic strain energy of inclusions with ellipsoidal shapes (described by the axes a, b, and c) that are subjected to a volumetric transformation strain. The outcome of the study is two shape factors, one for the elastic strain energy and the other for the interface energy. Both quantities are provided in the form of easy-to-use diagrams. Furthermore, threshold elastic contrasts yielding strain energy shape factors with the value 1.0 for any ellipsoidal shape are studied.
Outcome of ERCP related to case-volume
Authors: Syrén Eva-Lena , Sandblom Gabriel , Enochsson Lars , Eklund Arne , Isaksson Bengt , Österberg Johanna , Eriksson Staffan
Published: January 2022

Background and aims

In some studies, high endoscopic retrograde cholangiopancreatography (ERCP) case-volume has been shown to correlate to high success rate in terms of successful cannulation and fewer adverse events. The aim of this study was to analyze the association between ERCP success and complications, and endoscopist and centre case-volumes.

Methods

Data were obtained from the Swedish National Register for Gallstone Surgery and ERCP (GallRiks) on all ERCPs performed for Common Bile Duct Stone (CBDS) (n = 17,873) and suspected or confirmed malignancy (n = 6152) between 2009 and 2018. Successful cannulation rate, procedure time, intra- and postoperative complication rates and post-ERCP pancreatitis (PEP) rate, were compared with endoscopist and centre ERCP case-volumes during the year preceding the procedure as predictor.

Results

In multivariable analyses of the CBDS group adjusting for age, gender and year, a high endoscopist case-volume was associated with higher successful cannulation rate, lower complication and PEP rates, and shorter procedure time (p < 0.05). Centres with a high annual case-volume were associated with high successful cannulation rate and shorter procedure time (p < 0.05), but not lower complication and PEP rates.

When indication for ERCP was malignancy, a high endoscopist case-volume was associated with high successful cannulation rate and low PEP rates (p < 0.05), but not shorter procedure time or low complication rate. Centres with high case-volume were associated with high successful cannulation rate and low complication and PEP rates (p < 0.05), but not shorter procedure time.

Conclusions

The results suggest that higher endoscopist and centre case-volumes are associated with safer ERCP and successful outcome.
Different degeneration patterns of paraspinal muscles in degenerative lumbar diseases: a MRI analysis of 154 patients
Authors: Ding Jun-zhe , Kong Chao , Li Xiang-yu , Sun Xiang-yao , Lu Shi-bao , Zhao Guo-gunag
Published: January 2022

Study design

A retrospective study.

Objective

To evaluate the different degeneration patterns of paraspinal muscles in degenerative lumbar diseases and their correlation with lumbar spine degeneration severity.

Summary of background data

The degeneration characteristics of different paraspinal muscles in degenerative lumbar diseases remain unclear.

Methods

78 patients diagnosed with single-level degenerative lumbar spondylolisthesis (DLS) and 76 patients with degenerative lumbar kyphosis (DLK) were included as DLS and DLK groups. Paraspinal muscle parameters of psoas major (PS), erector spinae (ES) and multifidus muscle (MF) were measured, including fatty infiltration (FI) and relative cross-sectional area (rCSA), namely the ratio of the paraspinal muscle CSA to the CSA of the vertebrae of the same segment. Sagittal parameters including lumbar lordosis (LL) and sagittal vertical axis (SVA) were measured. The paraspinal muscle parameters and ES/MF rCSA ratio were compared between the two groups. Paraspinal muscles parameters including rCSA and FI were also compared between each segments from L1 to L5 in both DLS and DLK groups. In order to determine the influence of sagittal spinal alignment on paraspinal muscle parameters, correlation analysis was conducted between the MF, ES, PS rCSA and FI and the LL in DLS and DLK group.

Result

MF atrophy is more significant in DLS patients compared with DLK. Also, MF fatty infiltration in the lower lumbar spine of DLS patients was greater compared to DLK patients. DLK patients showed more significant atrophy of ES and heavier ES fatty infiltration. MF FI was significantly different between all adjacent segments in both DLS and DLK groups. In DLS group, ES FI was significantly different between L2/L3 to L3/L4 and L4/L5 to L5/S1, while in DLK group, the difference of ES FI between all adjacent segments was not significant, and ES FI was found negatively correlated with LL.

Conclusions

Paraspinal muscles show different degeneration patterns in degenerative lumbar diseases. MF degeneration is segmental in both DLS and DLK patients, while ES degenerated diffusely in DLK patients and correlated with the severity of kyphosis. MF degeneration is more significant in the DLS group, while ES degeneration is more significant in DLK patients. MF is the stabilizer of the lumbar spine segments, while the ES tends to maintain the spinal sagittal balance.
Complete genome sequence of a novel secovirid infecting cassava in the Americas
Authors: Leiva Ana M. , Jimenez Jenyfer , Sandoval Hector , Perez Shirley , Cuellar Wilmer J.
Published: January 2022

We report the complete genome sequence of a field isolate of a novel bipartite secovirid infecting cassava in Colombia, provisionally named "cassava torrado-like virus" (CsTLV). The genome sequence was obtained using Oxford Nanopore Technology, and the 5’ ends were confirmed by RACE. The RNA1 is 7252 nucleotides (nt) long, encoding a polyprotein of 2336 amino acids (aa) containing the typical “replication block”, conserved torradovirus motifs, and a Maf/Ham1 domain, which is not commonly found in viral genomes. The RNA2 is 4469 nt long and contains two overlapping ORFs encoding proteins of 226 and 1179 aa, showing the characteristic genome arrangement of members of the genus Torradovirus.
Quantitative assessment of information quality in textual sources for landslide inventories
Authors: Kreuzer Thomas M. , Damm Bodo , Terhorst Birgit
Published: January 2022

Landslide research chiefly relies on digital inventories for a multitude of spatial, temporal, and/or process analyses. In respect thereof, many landslide inventories are populated with information from textual documents (e.g., news articles, technical reports) due to effectiveness. However, information detail can vary greatly in these documents and the question arises whether such textual information is suitable for landslide inventories. The present work proposes to define the usefulness of textual source types as a probability to find landslide information, weighted with adaptable parameter requirements. To illustrate the method with practical results, a German landslide dataset has been examined. It was found that three combined source types (administrative documents, expert opinions, and news articles) give an 89 % chance to detect useful information on three defined parameters (location, date, and process type). In conclusion, the definition of usefulness as a probability makes it an intuitive, quantitative measure that is suitable for a wide range of applicants. Furthermore, a priori knowledge of usefulness allows for focusing on a few source types with the most promising outcome and thus increases the effectiveness of textual data acquisition and digitalisation for landslide inventories.
Non-smooth dynamic modeling and simulation of an unmanned bicycle on a curved pavement
Authors: Zhang Kaiming , Zheng Xudong , Chen Zhang , Liang Bin , Wang Tianshu , Wang Qi
Published: January 2022

The non-smooth dynamic model of an unmanned bicycle is established to study the contact-separate and stick-slip non-smooth phenomena between wheels and the ground. According to the Carvallo-Whipple configuration, the unmanned bicycle is reduced to four rigid bodies, namely, rear wheel, rear frame, front fork, and front wheel, which are connected by perfect revolute joints. The interaction between each wheel and the ground is simplified as the normal contact force and the friction force at the contact point, and these forces are described by the Hunt-Crossley contact force model and the LuGre friction force model, respectively. According to the characteristics of flat and curved pavements, calculation methods for contact forces and their generalized forces are presented. The dynamics of the system is modeled by the Lagrange equations of the first kind, a numerical solution algorithm of the dynamic equations is presented, and the Baumgarte stabilization method is used to restrict the drift of the constraints. The correctness of the dynamic model and the numerical algorithm is verified in comparison with the previous studies. The feasibility of the proposed model is demonstrated by simulations under different motion states.
From Theory of Rhetoric to the Practice of Language Use: The Case of Appeals to Ethos Elements
Authors: Koszowy Marcin , Budzynska Katarzyna , Pereira-Fariña Martín , Duthie Rory
Published: January 2022

In their bookCommitment in Dialogue, Walton and Krabbe claim that formal dialogue systems for conversational argumentation are “not very realistic and not easy to apply”. This difficulty may make argumentation theory less well adapted to be employed to describe or analyse actual argumentation practice. On the other hand, the empirical study of real-life arguments may miss or ignore insights of more than the two millennia of the development of philosophy of language, rhetoric, and argumentation theory. In this paper, we propose a novel methodology for adapting such theories to serve as applicable tools in the study of argumentation phenomena. Our approach is boththeoretically-informedandempirically-groundedin large-scale corpus analysis. The area of interest are appeals to ethos, the character of the speaker, building upon Aristotle’s rhetoric. Ethotic techniques are used to influence the hearers through the communication, where speakers might establish, but also emphasise, weaken or undermine their own or others’ credibility and trustworthiness. Specifically, we apply our method to Aristotelian theory of ethos elements which identifiespractical wisdom,moral virtueandgoodwillas components of speakers’ character, which can be supported or attacked. The challenges we identified in this case and the solutions we proposed allow us to formulate general guidelines of how to exploit rich theoretical frameworks to the analysis of the practice of language use.
When can cultural selection explain adaptation?
Authors: Chellappoo Azita
Published: January 2022

Cultural selection models aim to explain cultural phenomena as the products of a selective process, often characterising institutions, practices, norms or behaviours as adaptations. I argue that a lack of attention has been paid to the explanatory power of cultural selection frameworks. Arguments for cultural selection frequently depend on demonstrating only that selection models can in principle be applied to culture, rather than explicitly demonstrating the explanatory payoffs that could arise from their application. Understanding when and how cultural selection generates powerful explanations is crucial to evaluating cultural selection, as well as realising its promised epistemic and practical benefits. I argue that the ability for cultural selection to explain ‘design without a designer’ is crucial to successful and powerful cultural selection explanations. I introduce the strategy of comparing cultural selection to goal-directed agent accounts in order to evaluate when cultural selection can provide distinctive explanatory payoffs, drawing on two case studies to illustrate the benefits of this strategy. I argue that a focus on phenomena which cannot be explained through intention or agency-based explanations in particular could provide a fruitful avenue to identifying the cases where cultural selection can be insightfully applied.
What is a Beautiful Experiment?
Authors: Ivanova Milena
Published: January 2022

This article starts an engagement on the aesthetics of experiments and offers an account for analysing how aesthetics features in the design, evaluation and reception of experiments. I identify two dimensions of aesthetic evaluation of experiments: design and significance. When it comes to design, a number of qualities, such as simplicity, economy and aptness, are analysed and illustrated with the famous Meselson-Stahl experiment. Beautiful experiments are also regarded to make significant discoveries, but I argue against a narrow construal of experimental aims. By drawing on the plurality of goals experimenters have and diversity of aesthetic responses, I argue that experiments are aesthetically appreciated both when they discover and when they produce disruptive results.
Analysis of genetic diversity in Prunus sibirica L. in inner Mongolia using SCoT molecular markers
Authors: Buer Ha , Rula Sa , Wang Zi Yuan , Fang Shu , Bai Yu´e
Published: January 2022

Population genetic diversity contributes to the protection and utilization of germplasm resources, especially via genetic breeding. In the present study, start codon targeted polymorphism (SCoT) molecular markers were used to study the genetic diversity of 278 individuals from 10 Prunus sibirica L. populations in Inner Mongolia. A total of 289 polymorphic bands were amplified with 23 SCoT primers, showing a polymorphism percentage of 98.87% and an average of 12.6 polymorphic bands per primer. The SCoT21, SCoT32, and SCoT53 primers amplified up to 17 bands, and the polymorphism percentage was 100%. The minimum number of bands amplified by SCoT25 was 9, and the polymorphism percentage was 90%. Therefore, SCoT molecular markers were shown to be highly polymorphic and suitable for genetic diversity studies of P. sibirica in Inner Mongolia. The analysis of molecular variance showed that 39% of the observed genetic differentiation occurred among populations and 61% occurred within populations, indicating that the genetic differentiation within populations was greater than that among populations. The results of the unweighted pair-group method with an arithmetic cluster analysis, principal coordinate analysis and STRUCTURE analysis were basically the same and divided the 278 individuals from the 10 populations into 2 groups. The results indicated that the efficient SCoT molecular marker-based genetic diversity analysis of P. sibirica in Inner Mongolia can provide a reference for P. sibirica variety breeding and resource development.
The influence of carbon morphologies and concentrations on the rheology and electrical performance of screen-printed carbon pastes
Authors: Potts Sarah-Jane , Korochkina Tatyana , Holder Alex , Jewell Eifion , Phillips Chris , Claypole Tim
Published: January 2022

Screen-printing inks containing various morphologies of carbon are used in the production of a variety of printed electronics applications. Particle morphology influences the rheology of the ink which will affect the deposition and therefore the electrical performance of a printed component. To assess the effect of both carbon morphology and concentration on print topography and conductivity, screen printable carbon inks with differing loading concentrations of graphite, carbon black and graphite nanoplatelets (GNPs) were formulated, printed and characterised, with rheological and novel print visualisation techniques used to elucidate the mechanisms responsible. Carbon morphology had significant effects on the packing of particles. The smaller carbon black particles had more interparticle interactions leading to better conductivities, but also higher ink viscosities and elasticities than the other morphologies. Increases in carbon concentration led to increases in film thickness and roughness for all morphologies. However, beyond a critical point further increases in carbon concentration led to agglomerations of particles, mesh marking and increases in surface roughness, preventing further improvements in the print conductivity. The optimal loading concentrations were identifiable using a custom-made screen-printing apparatus used with high speed imaging for all morphologies. Notable increases in filamentation during ink separation were found to occur with further increases in carbon concentration beyond the optimum. As this point could not be identified using shear rheology alone, this method combined with shear rheology could be used to optimise the carbon concentration of screen-printing inks, preventing the use of excess material which has no benefit on print quality and conductivity.
An aligned fibrous and thermosensitive hyaluronic acid-puramatrix interpenetrating polymer network hydrogel with mechanical properties adjusted for neural tissue
Authors: Abbasi Aval Negar , Emadi Rahmatollah , Valiani Ali , Kharaziha Mahshid , Finne-Wistrand Anna
Published: January 2022

Central nervous system (CNS) injuries such as stroke or trauma can lead to long-lasting disability, and there is no currently accepted treatment to regenerate functional CNS tissue after injury. Hydrogels can mimic the neural extracellular matrix by providing a suitable 3D structure and mechanical properties and have shown great promise in CNS tissue regeneration. Here we present successful synthesis of a thermosensitive hyaluronic acid-RADA 16 (Puramatrix™) peptide interpenetrating network (IPN) that can be applied in situ by injection.

Thermosensitive hyaluronic acid (HA) was first synthesized by combining HA with poly(N-isopropylacrylamide). Then, the Puramatrix™ self-assembled peptide was combined with the thermosensitive HA to produce a series of injectable thermoresponsive IPNs. The HA-Puramatrix™ IPNs formed hydrogels successfully at physiological temperature. Characterization by SEM, rheological measurements, enzymatic degradation and swelling tests was performed to select the IPN optimized for neurologic use. SEM images of the optimized dry IPNs demonstrated an aligned porous structure, and the rheological measurements showed that the hydrogels were elastic, with an elastic modulus of approximately 500 Pa, similar to that of brain tissue. An evaluation of the cell–material interactions also showed that the IPN had biological characteristics required for tissue engineering, strongly suggesting that the IPN hydrogel possessed properties beneficial for regeneration of brain tissue.
Sugar decorated star-shaped (co)polymers with resveratrol-based core – physicochemical and biological properties
Authors: Bielas Rafał , Maksym Paulina , Erfurt Karol , Hachuła Barbara , Gawecki Robert , Tarnacka Magdalena , Waśkiewicz Sylwia , Mielańczyk Łukasz , Mrozek-Wilczkiewicz Anna , Chrobok Anna , Paluch Marian , Kamiński Kamil
Published: January 2022

Star-shaped glycopolymers due to the attractive combination of the physicochemical, morphological, self-assembly properties along with biological activity have gained increased attention as innovative agents in novel cancer therapies. Unfortunately, the production of these highly desirable biomaterials remains a challenge in modern macromolecular chemistry. The main reason for that is the low polymerizability of ionic glycomonomers originated from their steric congestion and the occurrence of ionic interactions that generally negatively influence the polymerization progress and hinder controllable reaction pathway. In this work, the new ionic sugar monomer was (co)polymerized for the first time via Activator Generated by Electron Transfer Atom Transfer Radical Polymerization (AGET ATRP) using a three-arm resveratrol-based core to obtain star-like (co)polymers. The obtained products were examined in terms of their physicochemical properties and morphology. Aside from the synthesis of these new glycopolymers, also a thorough description of their thermal properties, ability to self-assembly, the formation of stable superstructures was studied in detail. It was found that examined (co)polymers did not show any heterogeneities and phase separation, while their variation of glass transition temperature (Tg) was strictly related to the change in the number of glycomonomer. Also, the stability and shapes of formed superstructures strictly depend on their composition and topology. Finally, we have shown that synthesized carbohydrate-based polymers revealed high antiproliferative activity against several cancer cell lines (i.e., breast, colon, glioma, and lung cancer). The cytotoxic activity was particularly observed for star-shaped polymers that were systematically enhanced with the growing concentration of amine moieties and molecular weight. The results presented herein suggest that synthesized star-shaped glyco(co)polymers are promising as drug or gene carriers in anticancer therapies or anti-tumor agents, depending on their cytotoxicity.

Graphical abstract
The use of carefully planned board work to support the productive discussion of multiple student responses in a Japanese problem-solving lesson
Authors: Baldry Fay , Mann Jacqueline , Horsman Rachael , Koiwa Dai , Foster Colin
Published: January 2022

In this paper, we analyse a grade 8 (age 13–14) Japanese problem-solving lesson involving angles associated with parallel lines, taught by a highly regarded, expert Japanese mathematics teacher. The focus of our observation was on how the teacher used carefully planned board work to support a rich and extensive plenary discussion (neriage) in which he shifted the focus from individual mathematical solutions to generalised properties. By comparing the teacher’s detailed prior planning of the board work (bansho) with that which he produced during the lesson, we distinguish between aspects of the lesson that he considered essential and those he treated as contingent. Our analysis reveals how the careful planning of the board work enabled the teacher to be free to explore with the students the multiple alternative solution methods that they had produced, while at the same time having a clear overall purpose relating to how angle properties can be used to find additional solution methods. We outline how these findings from within the strong tradition of the Japanese problem-solving lesson might inform research and teaching practice outside of Japan, where a deep heritage of bansho and neriage is not present. In particular, we highlight three prominent features of this teacher’s practice: the detailed lesson planning in which particular solutions were prioritised for discussion; the considerable amount of time given over to student generation and comparison of alternative solutions; and the ways in which the teacher’s use of the board was seen to support the richness of the mathematical discussions.
Comparison of zero heat flux and double sensor thermometers during spinal anaesthesia: a prospective observational study
Authors: Lauronen Sirkka-Liisa , Kalliomäki Maija-Liisa , Kalliovalkama Jarkko , Aho Antti , Huhtala Heini , Yli-Hankala Arvi M. , Mäkinen Marja-Tellervo
Published: January 2022

Because of the difficulties involved in the invasive monitoring of conscious patients, core temperature monitoring is frequently neglected during neuraxial anaesthesia. Zero heat flux (ZHF) and double sensor (DS) are non-invasive methods that measure core temperature from the forehead skin. Here, we compare these methods in patients under spinal anaesthesia. Sixty patients scheduled for elective unilateral knee arthroplasty were recruited and divided into two groups. Of these, thirty patients were fitted with bilateral ZHF sensors (ZHF group), and thirty patients were fitted with both a ZHF sensor and a DS sensor (DS group). Temperatures were saved at 5-min intervals from the beginning of prewarming up to one hour postoperatively. Bland–Altman analysis for repeated measurements was performed and a proportion of differences within 0.5 °C was calculated as well as Lin`s concordance correlation coefficient (LCCC). A total of 1261 and 1129 measurement pairs were obtained. The mean difference between ZHF sensors was 0.05 °C with 95% limits of agreement − 0.36 to 0.47 °C, 99% of the readings were within 0.5 °C and LCCC was 0.88. The mean difference between ZHF and DS sensors was 0.33 °C with 95% limits of agreement − 0.55 to 1.21 °C, 66% of readings were within 0.5 °C and LCCC was 0.59. Bilaterally measured ZHF temperatures were almost identical. DS temperatures were mostly lower than ZHF temperatures. The mean difference between ZHF and DS temperatures increased when the core temperature decreased.

Trial registration: The study was registered in ClinicalTrials.gov on 13th May 2019, Code NCT03408197.
On the occurrence, origin, and intake of the nuclides, 210Po and 210Pb, in sclerotia of Wolfiporia cocos collected in China
Authors: Strumińska-Parulska Dagmara , Falandysz Jerzy , Moniakowska Aleksandra
Published: January 2022

The dried sclerotium of the fungus Wolfiporia cocos is edible and has medicinal value. This study aimed to understand the accumulation of radioactivity arising from the alpha 210Po, and beta-emitting 210Pb, in the sclerotium’s shell and core and assess a potential effective dose for consumers. Sclerotia were collected in the wild and from cultivars in China’s Anhui and Yunnan provinces. The mean values of 210Po activity concentration levels were 0.36 Bq kg−1 dry weight in the core and 12.0 Bq kg−1 dw in the shell; 210Pb activities were 0.43 and 9.84 Bq kg−1 dw, respectively. The potential effective radiation doses from core layers (as a major raw material of the sclerotium) ranged from 0.13 to 3.43 µSv kg−1 dw from 210Po decay and from 0.11 to 1.52 µSv kg−1 dw from 210Pb decay. Corresponding values for shell ranged from 0.80 to 42.4 for 210Po and from 0.53 to 13.6 µSv kg−1 dw for 210Pb. In general, the intake of W. cocos sclerotia varies between consumers, but this would not significantly change the effective radiation doses from 210Po and 210Pb isotopes. The consumption thus appears to be safe from a radiological protection point of view.

Graphical abstract
Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2)
Authors: Jayanthi Subramaniam , Peesapati Ritvik , McCoy Michael T. , Ladenheim Bruce , Cadet Jean Lud
Published: January 2022

Methamphetamine (METH) use disorder (MUD) is characterized by compulsive and repeated drug taking despite negative life consequences. Large intake of METH in humans and animals is accompanied by dysfunctions in learning and memory processes. The endocannabinoid system (ECS) is known to modulate synaptic plasticity and cognitive functions. In addition, the ECS has been implicated in some of the manifestations of substance use disorders (SUDs). We therefore sought to identify potential changes in the expression of various enzymes and of the receptors (CB1 and CB2) that are members of that system. Herein, we used a model of METH self-administration (SA) that includes a punishment phase (footshocks) that helps to separate rats into a compulsive METH phenotype (compulsive) that continues to take METH and a non-compulsive METH (abstinent) group that suppressed or stopped taking METH. Animals were euthanized 2 h after the last METH SA session and their hippocampi were used to measure mRNA levels of cannabinoid receptors (CB/Cnr), as well as those of synthesizing (DAGL-A, DAGL-B, NAPEPLD) and metabolizing (MGLL, FAAH, PTGS2) enzymes of the endocannabinoid cascade. Non-compulsive rats exhibited significant increased hippocampal expression of CB1/Cnr1 and CB2/Cnr2 mRNAs. mRNA levels of the synthesizing enzyme, DAGL-A, and of the metabolic enzymes, MGLL and FAAH, were also increased. Non-compulsive rats also exhibited a significant decrease in hippocampal Ptgs2 mRNA levels. Taken together, these observations implicate the hippocampal endocannabinoid system in the suppression of METH intake in the presence of adverse consequences.