bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementing the RECONAC Marketing Strategy for the Interaction and Brand Adoption of Peruvian University Students
Authors: Sánchez-Garcés Jorge , J. Soria Juan , Turpo-Chaparro Josué E. , Avila-George Himer , López-Gonzales Javier Linkolk
Published: February 2021

In marketing, there is a notable lack of models, which leads to the loss of potential customers since there is no feedback for improvement in the marketing strategy. In the face of the Internet revolution, this study used digital channels and interaction to achieve potential customer retention through a Funnel; this allowed a potential client to go through the acquisition, conversion, and retention stages. In addition, activities were developed that allow the potential user to become a retained client. Thus, considering the stages of a marketing strategy, a non-probabilistic sample was used, composed of a pre-test period with 1088 users and a post-test period with 1450 users. Overall, there was a significant improvement in the time a client remained observing the website per session, with a 20.6% efficiency; furthermore, there was a 36.25% efficiency increase of the user conversion process per session in the digital channel. Likewise, a 46.43% efficiency increase was measured in visits to the digital channel, which confirms that the proposed marketing strategy significantly improves previous marketing strategies. Therefore, it is concluded that the proposal based on the elements of insight aligned with the measurement proposed by Google Analytics Key Performance Indicators, which was used to test and observe the improvements to continue the feedback, taking advantage of the characteristic of the digital channel with its two-way participation.
Radiochromic Films for the Two-Dimensional Dose Distribution Assessment
Authors: Casolaro Pierluigi
Published: February 2021

Radiochromic films are mainly used for two-dimensional dose verification in photon, electron, and proton therapy treatments. Moreover, the radiochromic film types available today allow their use in a wide dose range, corresponding to applications from low-medical diagnostics to high-dose beam profile measurements in charged particle medical accelerators. An in-depth knowledge of the characteristics of radiochromic films, of their operating principles, and of the dose reading techniques is of paramount importance to exploit all the features of this interesting and versatile radiation detection system. This short review focuses on these main aspects by considering the most recent works on the subject.
Investigating the Spatio-Temporal Distribution of Gravity Wave Potential Energy over the Equatorial Region Using the ERA5 Reanalysis Data
Authors: Yang Shih-Sian , Pan Chen-Jeih , Das Uma
Published: February 2021

Atmospheric gravity waves play a crucial role in affecting atmospheric circulation, energy transportation, thermal structure, and chemical composition. Using ERA5 temperature data, the present study investigates the tropospheric to the lower mesospheric gravity wave potential energy (EP) over the equatorial region to understand the vertical coupling of the atmosphere. EP is mainly controlled by two factors. The first is zonal wind through wave–mean flow interactions, and thus EP has periodic variations that are correlated to the zonal wind oscillations and enhances around the altitudes of zero-wind shears where the zonal wind reverses. The second is the convections caused by atmospheric circulations and warm oceans, resulting in longitudinal variability in EP. The lower stratospheric and the lower mesospheric EP are negatively correlated. However, warm oceanic conditions can break this wave energy coupling and further enhance the lower mesospheric EP.
Features Exploration from Datasets Vision in Air Quality Prediction Domain
Authors: Iskandaryan Ditsuhi , Ramos Francisco , Trilles Sergio
Published: February 2021

Air pollution and its consequences are negatively impacting on the world population and the environment, which converts the monitoring and forecasting air quality techniques as essential tools to combat this problem. To predict air quality with maximum accuracy, along with the implemented models and the quantity of the data, it is crucial also to consider the dataset types. This study selected a set of research works in the field of air quality prediction and is concentrated on the exploration of the datasets utilised in them. The most significant findings of this research work are: (1) meteorological datasets were used in 94.6% of the papers leaving behind the rest of the datasets with a big difference, which is complemented with others, such as temporal data, spatial data, and so on; (2) the usage of various datasets combinations has been commenced since 2009; and (3) the utilisation of open data have been started since 2012, 32.3% of the studies used open data, and 63.4% of the studies did not provide the data.
Coefficients of a Comprehensive Subclass of Meromorphic Bi-Univalent Functions Associated with the Faber Polynomial Expansion
Authors: Srivastava Hari , Motamednezhad Ahmad , Salehian Safa
Published: February 2021

In this paper, we introduce a new comprehensive subclass ΣB(λ,μ,β) of meromorphic bi-univalent functions in the open unit disk U. We also find the upper bounds for the initial Taylor-Maclaurin coefficients |b0|, |b1| and |b2| for functions in this comprehensive subclass. Moreover, we obtain estimates for the general coefficients |bn|(n≧1) for functions in the subclass ΣB(λ,μ,β) by making use of the Faber polynomial expansion method. The results presented in this paper would generalize and improve several recent works on the subject.
A Newly Assigned Role of CTCF in Cellular Response to Broken DNAs
Authors: Kang Mi Ae , Lee Jong-Soo
Published: February 2021

Best known as a transcriptional factor, CCCTC-binding factor (CTCF) is a highly conserved multifunctional DNA-binding protein with 11 zinc fingers. It functions in diverse genomic processes, including transcriptional activation/repression, insulation, genome imprinting and three-dimensional genome organization. A big surprise has recently emerged with the identification of CTCF engaging in the repair of DNA double-strand breaks (DSBs) and in the maintenance of genome fidelity. This discovery now adds a new dimension to the multifaceted attributes of this protein. CTCF facilitates the most accurate DSB repair via homologous recombination (HR) that occurs through an elaborate pathway, which entails a chain of timely assembly/disassembly of various HR-repair complexes and chromatin modifications and coordinates multistep HR processes to faithfully restore the original DNA sequences of broken DNA sites. Understanding the functional crosstalks between CTCF and other HR factors will illuminate the molecular basis of various human diseases that range from developmental disorders to cancer and arise from impaired repair. Such knowledge will also help understand the molecular mechanisms underlying the diverse functions of CTCF in genome biology. In this review, we discuss the recent advances regarding this newly assigned versatile role of CTCF and the mechanism whereby CTCF functions in DSB repair.
Obesity Affects HDL Metabolism, Composition and Subclass Distribution
Authors: Stadler Julia T. , Lackner Sonja , Mörkl Sabrina , Trakaki Athina , Scharnagl Hubert , Borenich Andrea , Wonisch Willibald , Mangge Harald , Zelzer Sieglinde , Meier-Allard Nathalie , Holasek Sandra J. , Marsche Gunther
Published: February 2021

Background: Obesity increases the risk of coronary heart disease, partly due to its strong association with atherogenic dyslipidemia, characterized by high triglycerides and low high-density lipoprotein (HDL) cholesterol levels. Functional impairment of HDL may contribute to the increased cardiovascular mortality, but the effect of obesity on composition, structure, and function of HDL is not well understood. Design and Methods: We determined HDL composition, HDL subclass distribution, parameters of HDL function, and activities of most important enzymes involved in lipoprotein remodeling, including lecithin–cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in relatively young normal weight (n = 26), overweight (n = 22), and obese (n = 20) women. Results: Obesity (body mass index (BMI) ≥ 30) was associated with noticeable changes in LCAT and CETP activities and altered HDL composition, such as decreased apolipoprotein A-I, cholesterol, and phospholipid content, while pro-inflammatory HDL serum amyloid a content was increased. We observed a marked shift towards smaller HDL subclasses in obesity linked to lower anti-oxidative capacity of serum. LCAT activity, HDL subclass distribution, and HDL-cholesterol were associated with soluble leptin receptor, adiponectin, and liver enzyme activities. Of note, most of these alterations were only seen in obese women but not in overweight women. Conclusions: Obesity markedly affects HDL metabolism, composition, and subclass distribution linked to changes in liver and adipose tissue. HDL dysfunction may contribute to increased cardiovascular risk in obesity.
The Dying Forward Hypothesis of ALS: Tracing Its History
Authors: Eisen Andrew
Published: February 2021

The site of origin of amyotrophic lateral sclerosis (ALS), although unsettled, is increasingly recognized as being cortico-fugal, which is a dying-forward process primarily starting in the corticomotoneuronal system. A variety of iterations of this concept date back to over 150 years. Recently, the hallmark TAR DNA-binding protein 43 (TDP-43) pathology, seen in >95% of patients with ALS, has been shown to be largely restricted to corticofugal projecting neurons (“dying forward”). Possibly, soluble but toxic cytoplasmic TDP-43 could enter the axoplasm of Betz cells, subsequently causing dysregulation of nuclear protein in the lower brainstem and spinal cord anterior horn cells. As the disease progresses, cortical involvement in ALS becomes widespread, including or starting with frontotemporal dementia, implying a broader view of ALS as a brain disease. The onset at the motor and premotor cortices should be considered a nidus at the edge of multiple cortical networks which eventually become disrupted, causing failure of a widespread cortical connectome.
Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis
Authors: Colletti Tiziana , Agnello Luisa , Spataro Rossella , Guccione Lavinia , Notaro Antonietta , Lo Sasso Bruna , Blandino Valeria , Graziano Fabiola , Gambino Caterina Maria , Giglio Rosaria Vincenza , Bivona Giulia , La Bella Vincenzo , Ciaccio Marcello , Piccoli Tommaso
Published: February 2021

The involvement of β-amyloid (Aβ) in the pathogenesis of amyotrophic lateral sclerosis (ALS) has been widely discussed and its role in the disease is still a matter of debate. Aβ accumulates in the cortex and the anterior horn neurons of ALS patients and seems to affect their survival. To clarify the role of cerebrospinal fluid (CSF) Aβ 1–42 and Aβ 42/40 ratios as a potential prognostic biomarker for ALS, we performed a retrospective observational study on a cohort of ALS patients who underwent a lumbar puncture at the time of the diagnosis. CSF Aβ 1–40 and Aβ 1–42 ratios were detected by chemiluminescence immunoassay and their values were correlated with clinical features. We found a significant correlation of the Aβ 42/40 ratio with age at onset and Mini Mental State Examination (MMSE) scores. No significant correlation of Aβ 1–42 or Aβ 42/40 ratios to the rate of progression of the disease were found. Furthermore, when we stratified patients according to Aβ 1–42 concentration and the Aβ 42/40 ratio, we found that patients with a lower Aβ 42/40 ratio showed a shorter survival. Our results support the hypothesis that Aβ 1–42 could be involved in some pathogenic mechanism of ALS and we suggest the Aβ 42/40 ratio as a potential prognostic biomarker.
TMS–EEG Co-Registration in Patients with Mild Cognitive Impairment, Alzheimer’s Disease and Other Dementias: A Systematic Review
Authors: Nardone Raffaele , Sebastianelli Luca , Versace Viviana , Ferrazzoli Davide , Saltuari Leopold , Trinka Eugen
Published: February 2021

An established method to assess effective brain connectivity is the combined use of transcranial magnetic stimulation with simultaneous electroencephalography (TMS–EEG) because TMS-induced cortical responses propagate to distant anatomically connected brain areas. Alzheimer’s disease (AD) and other dementias are associated with changes in brain networks and connectivity, but the underlying pathophysiology of these processes is poorly defined. We performed here a systematic review of the studies employing TMS–EEG co-registration in patients with dementias. TMS–EEG studies targeting the motor cortex have revealed a significantly reduced TMS-evoked P30 in AD patients in the temporo-parietal cortex ipsilateral to stimulation side as well as in the contralateral fronto-central area, and we have demonstrated a deep rearrangement of the sensorimotor system even in mild AD patients. TMS–EEG studies targeting other cortical areas showed alterations of effective dorsolateral prefrontal cortex connectivity as well as an inverse correlation between prefrontal-to-parietal connectivity and cognitive impairment. Moreover, TMS–EEG analysis showed a selective increase in precuneus neural activity. TMS–EEG co-registrations can also been used to investigate whether different drugs may affect cognitive functions in patients with dementias.
MnOx Supported on Hierarchical SAPO-34 for the Low-Temperature Selective Catalytic Reduction of NO with NH3: Catalytic Activity and SO2 Resistance
Authors: Zhou Lusha , Guan Jinkun , Yu Chenglong , Huang Bichun
Published: February 2021

The ethanol dispersion method was employed to synthesize a series of MnOx/SAPO-34 catalysts using SAPO-34 with the hierarchical pore structure as the zeolite carrier, which were prepared by facile acid treatment with citric acid. Physicochemical properties of catalysts were characterized by XRD, XPS, BET, TEM, NH3-TPD, SEM, FT-IR, Py-IR, H2-TRP and TG/DTG. NH3-SCR performances of the hierarchical MnOx/SAPO-34 catalysts were evaluated at low temperatures. Results show that citric acid etching solution at a concentration of 0.1 mol/L yielded a hierarchical MnOx/SAPO-34-0.1 catalyst with ca.15 wt.% Mn loading, exhibiting optimal catalytic activity and SO2 tolerance at low temperatures. Almost 100% NO conversion and over 90% N2 selectivity at 120 °C under a gas hourly space velocity (GHSV) of 40,000 h−1 could be obtained over this sample. Furthermore, the NO conversion was still higher than 65% when 100 ppm SO2 was introduced to the reaction gas for 4 h. These could be primarily attributed to the large specific surface area, high surface acidity concentration and abundant chemisorbed oxygen species provided by the hierarchical pore structure, which could also increase the mass transfer of the reaction gas. This finding suggests that the NH3-SCR activity and SO2 poisoning tolerance of hierarchical MnOx/SAPO-34 catalysts at low temperatures can be improved by controlling the morphology of the catalysts, which might supply a rational strategy for the design and synthesis of Mn-based SCR catalysts.
Electrocatalysts for Using Renewably-Sourced, Organic Electrolytes for Redox Flow Batteries
Authors: Weber Robert S.
Published: February 2021

Biomass could be a source of the redox shuttles that have shown promise for operation as high potential, organic electrolytes for redox flow batteries. There is a sufficient quantity of biomass to satisfy the growing demand to buffer the episodic nature of renewably produced electricity. However, despite a century of effort, it is still not evident how to use existing information from organic electrochemistry to design the electrocatalysts or supporting electrolytes that will confer the required activity, selectivity and longevity. In this research, the use of a fiducial reaction to normalize reaction rates is shown to fail.
Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients
Authors: Garcia Joao Pedro , Utomo Lizette , Rudnik-Jansen Imke , Du Jie , Zuithoff Nicolaas P.A. , Krouwels Anita , van Osch Gerjo J.V.M. , Creemers Laura B.
Published: February 2021

Pro-inflammatory cytokines are considered to play a major role in osteoarthritis (OA), yet so far, the specific cytokines involved in the pathology of OA have not been identified. Oncostatin M (OSM) is a cytokine from the interleukin 6 (IL-6) family that has been shown to be elevated in synovial fluid of most rheumatoid arthritis (RA) patients, but only in a limited subset of OA patients. Little is known about OSM in the different joint tissues during OA and how its expression correlates with hallmarks of disease. Here, we mapped OSM expression in the joint tissues of two rat models of arthritis: an acute inflammatory model and an instability-induced osteoarthritic model. OSM expression was correlated with hallmarks of OA, namely cartilage damage, synovitis, and osteophyte formation. Reanalysis of an existing dataset on cytokine profiling of OA synovial fluid was performed to assess pattern differences between patients positive and negative for OSM. In the inflammatory model, OSM expression correlated with synovitis and osteophyte formation but not with cartilage damage. On the contrary, in the instability model of OA, an increase in synovitis, cartilage damage, and osteophyte formation was observed without changes in OSM expression. In line with these findings, synovial fluid of OA patients with detectable OSM contained higher levels of other inflammatory cytokines, namely interferon gamma (IFN-γ), IL-1α and tumor necrosis factor alpha (TNF-α), likely indicating a more inflammatory state. Taken together these data indicate OSM might play a prominent role in inflammatory phenotypes of OA.
Structures, Biosynthesis, and Physiological Functions of (1,3;1,4)-β-d-Glucans
Authors: Chang Shu-Chieh , Saldivar Rebecka Karmakar , Liang Pi-Hui , Hsieh Yves S. Y.
Published: February 2021

(1,3;1,4)-β-d-Glucans, also named as mixed-linkage glucans, are unbranched non-cellulosic polysaccharides containing both (1,3)- and (1,4)-β-linkages. The linkage ratio varies depending upon species origin and has a significant impact on the physicochemical properties of the (1,3;1,4)-β-d-glucans. (1,3;1,4)-β-d-Glucans were thought to be unique in the grasses family (Poaceae); however, evidence has shown that (1,3;1,4)-β-d-glucans are also synthesized in other taxa, including horsetail fern Equisetum, algae, lichens, and fungi, and more recently, bacteria. The enzyme involved in (1,3;1,4)-β-d-glucan biosynthesis has been well studied in grasses and cereal. However, how this enzyme is able to assemble the two different linkages remains a matter of debate. Additionally, the presence of (1,3;1,4)-β-d-glucan across the species evolutionarily distant from Poaceae but absence in some evolutionarily closely related species suggest that the synthesis is either highly conserved or has arisen twice as a result of convergent evolution. Here, we compare the structure of (1,3;1,4)-β-d-glucans present across various taxonomic groups and provide up-to-date information on how (1,3;1,4)-β-d-glucans are synthesized and their functions.
Purposeful Evaluation of Scholarship in the Open Science Era
Authors: Pagliaro Mario
Published: February 2021

In most of the world’s countries, scholarship evaluation for tenure and promotion continues to rely on conventional criteria of publications in journals of high impact factor and achievements in securing research funds. Continuing to hire and promote scholars based on these criteria exposes universities to risk because students, directly and indirectly through government funds, are the main source of revenues for academic institutions. At the same time, talented young researchers increasingly look for professors renowned for excellence in mentoring doctoral students and early career researchers. Purposeful scholarship evaluation in the open science era needs to include all three areas of scholarly activity: research, teaching and mentoring, and service to society.
1D Perovskitoid as Absorbing Material for Stable Solar Cells
Authors: Xu Fan , Li Yujing , Liu Na , Han Ying , Zou Meishuai , Song Tinglu
Published: February 2021

The instabilities of perovskite solar cells hinder their commercialisation. To resolve this problem, a one-dimensional (1D) perovskitoid, PyPbI3, was fabricated, and its structure and photovoltaic performance were investigated in this work. XPS and FTIR results suggest hydrogen bonds existed in the 1D hexagonal PyPbI3. Stability measurements indicate that 1D perovskitoid is much more stable than the commonly employed FA-based perovskite. In addition, solar cells adopting PyPbI3 as an absorbing layer led to a device lifetime of one month. Our results suggest that 1D perovskitoid has great potential to be employed in solar cells.
Helimagnetism in MnBi2Se4 Driven by Spin-Frustrating Interactions Between Antiferromagnetic Chains
Authors: Clark Judith , Pak Chongin , Cao Huibo , Shatruk Michael
Published: February 2021

We report the magnetic properties and magnetic structure determination for a linear-chain antiferromagnet, MnBi2Se4. The crystal structure of this material contains chains of edge-sharing MnSe6 octahedra separated by Bi atoms. The magnetic behavior is dominated by intrachain antiferromagnetic (AFM) interactions, as demonstrated by the negative Weiss constant of −74 K obtained by the Curie–Weiss fit of the paramagnetic susceptibility measured along the easy-axis magnetization direction. The relative shift of adjacent chains by one-half of the chain period causes spin frustration due to interchain AFM coupling, which leads to AFM ordering at TN = 15 K. Neutron diffraction studies reveal that the AFM ordered state exhibits an incommensurate helimagnetic structure with the propagation vector k = (0, 0.356, 0). The Mn moments are arranged perpendicular to the chain propagation direction (the crystallographic b axis), and the turn angle around the helix is 128°. The magnetic properties of MnBi2Se4 are discussed in comparison to other linear-chain antiferromagnets based on ternary mixed-metal halides and chalcogenides.
Comprehensive Management of Rheumatic Diseases Affecting the Temporomandibular Joint
Authors: Covert Lauren , Mater Heather Van , Hechler Benjamin L.
Published: February 2021

The temporomandibular joint (TMJ) is a synovial joint and thus is vulnerable to the afflictions that may affect other joints in the fields of rheumatology and orthopedics. Too often temporomandibular complaints are seen strictly as dental or orofacial concerns. Similarly, patients with known rheumatic disease may not have their TMJs included in routine screening and monitoring protocols. The purpose of this review is to highlight the rheumatic conditions likely to affect the TMJ and outline medical and surgical management in these patients with a focus on the need for continued patient reassessment and monitoring.
Forest Fire Smoke Recognition Based on Anchor Box Adaptive Generation Method
Authors: Zhao Enting , Liu Yang , Zhang Junguo , Tian Ye
Published: February 2021

There are major problems in the field of image-based forest fire smoke detection, including the low recognition rate caused by the changeable and complex state of smoke in the forest environment and the high false alarm rate caused by various interferential objects in the recognition process. Here, a forest fire smoke identification method based on the integration of environmental information is proposed. The model uses (1) the Faster R-CNN as the basic framework, (2) a component perception module to generate a receptive field of integrated environmental information through separable convolution to improve recognition accuracy, and (3) a multi-level Region of Interest (ROI)pooling structure to reduce the deviation caused by rounding in the ROI pooling process. The results showed that the model achieved a recognition accuracy rate of 96.72%, an Intersection Over Union (IOU) of 78.96%, and an average recognition speed for each picture of 1.5 ms; the false alarm rate was 2.35% and the false-negative rate was 3.28%. Compared with other models, the proposed model can effectively enhance the recognition accuracy and recognition speed of forest fire smoke, which provides a technical basis for the real-time and accurate detection of forest fires.
Ensemble-Based Out-of-Distribution Detection
Authors: Yang Donghun , Mai Ngoc Kien , Shin Iksoo , Lee Kyong-Ha , Hwang Myunggwon
Published: February 2021

To design an efficient deep learning model that can be used in the real-world, it is important to detect out-of-distribution (OOD) data well. Various studies have been conducted to solve the OOD problem. The current state-of-the-art approach uses a confidence score based on the Mahalanobis distance in a feature space. Although it outperformed the previous approaches, the results were sensitive to the quality of the trained model and the dataset complexity. Herein, we propose a novel OOD detection method that can train more efficient feature space for OOD detection. The proposed method uses an ensemble of the features trained using the softmax-based classifier and the network based on distance metric learning (DML). Through the complementary interaction of these two networks, the trained feature space has a more clumped distribution and can fit well on the Gaussian distribution by class. Therefore, OOD data can be efficiently detected by setting a threshold in the trained feature space. To evaluate the proposed method, we applied our method to various combinations of image datasets. The results show that the overall performance of the proposed approach is superior to those of other methods, including the state-of-the-art approach, on any combination of datasets.
A Cloud-Based Data Collaborative to Combat the COVID-19 Pandemic and to Solve Major Technology Challenges
Authors: Cappellari Max , Belstner John , Rodriguez Bryan , Sedayao Jeff
Published: February 2021

The XPRIZE Foundation designs and operates multi-million-dollar, global competitions to incentivize the development of technological breakthroughs that accelerate humanity toward a better future. To combat the COVID-19 pandemic, the foundation coordinated with several organizations to make datasets about different facets of the disease available and to provide the computational resources needed to analyze those datasets. This paper is a case study of the requirements, design, and implementation of the XPRIZE Data Collaborative, which is a Cloud-based infrastructure that enables the XPRIZE to meet its COVID-19 mission and host future data-centric competitions. We examine how a Cloud Native Application can use an unexpected variety of Cloud technologies, ranging from containers, serverless computing, to even older ones such as Virtual Machines. We also search and document the effects that the pandemic had on application development in the Cloud. We include our experiences of having users successfully exercise the Data Collaborative, detailing the challenges encountered and areas for improvement and future work.
Distributed Ledger Technology Review and Decentralized Applications Development Guidelines
Authors: Antal Claudia , Cioara Tudor , Anghel Ionut , Antal Marcel , Salomie Ioan
Published: February 2021

The Distributed Ledger Technology (DLT) provides an infrastructure for developing decentralized applications with no central authority for registering, sharing, and synchronizing transactions on digital assets. In the last years, it has drawn high interest from the academic community, technology developers, and startups mostly by the advent of its most popular type, blockchain technology. In this paper, we provide a comprehensive overview of DLT analyzing the challenges, provided solutions or alternatives, and their usage for developing decentralized applications. We define a three-tier based architecture for DLT applications to systematically classify the technology solutions described in over 100 papers and startup initiatives. Protocol and Network Tier contains solutions for digital assets registration, transactions, data structure, and privacy and business rules implementation and the creation of peer-to-peer networks, ledger replication, and consensus-based state validation. Scalability and Interoperability Tier solutions address the scalability and interoperability issues with a focus on blockchain technology, where they manifest most often, slowing down its large-scale adoption. The paper closes with a discussion on challenges and opportunities for developing decentralized applications by providing a multi-step guideline for decentralizing the design and implementation of traditional systems.
Sensory Reactivity Symptoms Are a Core Feature of ADNP Syndrome Irrespective of Autism Diagnosis
Authors: Siper Paige M. , Layton Christina , Levy Tess , Lurie Stacey , Benrey Nurit , Zweifach Jessica , Rowe Mikaela , Tang Lara , Guillory Sylvia , Halpern Danielle , Giserman-Kiss Ivy , Del Pilar Trelles Maria , Foss-Feig Jennifer H. , De Rubeis Silvia , Tavassoli Teresa , Buxbaum Joseph D. , Kolevzon Alexander
Published: February 2021

Background: Activity dependent neuroprotective protein (ADNP) syndrome is one of the most common single-gene causes of autism spectrum disorder (ASD) and intellectual disability, however, the phenotypes remain poorly described. Here we examine the sensory reactivity phenotype in children and adolescents with ADNP syndrome. Methods: Twenty-two individuals with ADNP syndrome received comprehensive clinical evaluations including standardized observations, caregiver interviews, and questionnaires to assess sensory reactivity symptoms. Relationships between sensory symptoms and age, sex, ASD, IQ, and adaptive behavior were examined. Genotype-phenotype correlations with the recurrent p.Tyr719* variant were also explored. Results: Sensory reactivity symptoms were observed and reported in all participants. A syndrome-specific phenotype was identified, characterized by high levels of sensory seeking across tactile, auditory, and visual domains. Tactile hyporeactivity, characterized by pain insensitivity, was reported in the majority of participants. Sensory symptoms were identified across individuals regardless of age, sex, IQ, adaptive ability, genetic variant, and most importantly, ASD status. No significant differences were identified between participants with and without the recurrent p.Tyr719* variant on any sensory measure. Conclusions: Sensory reactivity symptoms are a common clinical feature of ADNP syndrome. Quantifying sensory reactivity using existing standardized measures will enhance understanding of sensory reactivity in individuals with ADNP syndrome and will aid in clinical care. The sensory domain may also represent a promising target for treatment in clinical trials.
Henry James Reads Walter Scott Again
Authors: Herford Oliver
Published: February 2021

This article reassesses Henry James’s attitude to the historical novels of Walter Scott in light of James’s observation, made early on in the First World War, that the current global situation “makes Walter Scott, him only, readable again”. Scott’s novels were strongly associated for James with young readers and a juvenile, escapist mode of reading; and yet close attention to James’s comments on Scott in his criticism, notebooks and correspondence, and examination of a recurring image of children as readers and listeners to oral stories in the work of both authors, indicate that James engaged with Scott’s presentation of the historical and personal past more extensively and in more complex ways than have hitherto been suspected. Scott’s example as a novelist and editor notably informs James’s practice in several late works: the family memoir Notes of a Son and Brother (1914), the New York Edition of his novels and tales (1907–1909), and the unfinished, posthumously published novel The Sense of the Past (1917).
The Bounds of Narrative in Don DeLillo’s Underworld: Action and the Ecology of Mimêsis
Authors: Hagan Andrew Bowie
Published: February 2021

The interrelationship of natural and cultural history in Don DeLillo’s Underworld presents an ecology of mimesis. If, as Timothy Morton argues, ecological thought can be understood as a “mesh of interconnection,” DeLillo’s novel studies the interpretation of connection. Underworld situates its action in the Cold War era. DeLillo’s formal techniques examine the tropes of paranoia, containment, excess, and waste peculiar to the history of the Cold War. Parataxis and free-indirect discourse emphasize the contexts of reference in the novel, illustrating how hermeneutics informs the significance of boundaries. DeLillo’s use of parataxis exemplifies the conditions that propose and limit metaphor’s reference to reality, conditions that offer the terms for meaningful action. I utilize Paul Ricoeur’s hermeneutics to demonstrate how Underworld situates the reference to reality in its temporal and narrative condition. The historical situation of the novel’s narrative structure allows DeLillo to interrogate the role of discourse in producing and interpreting connection. Underworld offers layers of significance; the reader’s engagement with the novel’s discourse reaffirms the conditions of a meaningful relationship with reality in the pertinence of a metaphor.
Cherry Tomato Drying: Sun versus Convective Oven
Authors: Alfeo Vincenzo , Planeta Diego , Velotto Salvatore , Palmeri Rosa , Todaro Aldo
Published: February 2021

Solar drying and convective oven drying of cherry tomatoes (Solanum lycopersicum) were compared. The changes in the chemical parameters of tomatoes and principal drying parameters were recorded during the drying process. Drying curves were fitted to several mathematical models, and the effects of air temperature during drying were evaluated by multiple regression analyses, comparing to previously reported models. Models for drying conditions indicated a final water content of 30% (semidry products) and 15% (dry products) was achieved, comparing sun-drying and convective oven drying at three different temperatures. After 26–28 h of sun drying, the tomato tissue had reached a moisture content of 15%. However, less drying time, about 10–11 h, was needed when starting with an initial moisture content of 92%. The tomato tissue had high ORAC and polyphenol content values after convective oven drying at 60 °C. The dried tomato samples had a satisfactory taste, color and antioxidant values.
Gender Differences in Work Status during Early Career of Dentists: An Analysis of National Survey Cohort Data of 10 Years in Japan
Authors: Oshima Katsuo , Kodama Tomoko , Ida Yusuke , Miura Hiroko
Published: February 2021

Few studies have evaluated gender differences in young dentists’ career focusing on career breaks and return to work. We created a cohort dataset for dentists registered in 2006 using the national survey between 2006–2016 (men, 1680; women, 984), and examined the work setting of dentists by gender 10 years after registration. The proportion of dentists on career break increased each survey year, and was more pronounced in women than in men (2006 to 2016, men, 11.2% to 14.2%; women, 7.9% to 31.0%). The proportion of those who had career breaks between 2006–2016 was 44.8% in men and 62.9% in women. In the multiple logistic regression for examining the associations between those who returned to work compared to those working continuously, in women, the odds ratios (OR) were significantly higher in those working in dental clinics (owner, OR: 5.39; employee, OR: 3.10), and those working part-time (OR: 2.07); however, in men, there was no significant association with part-time work. These results suggest during early career phase, female dentists are more likely than males to take career breaks and choose part-time on returning. These gender differences should be considered for ensuring adequate workforce in dentistry in the future.
Veterinary-Prescribed Physical Activity: Feasibility and Acceptability among Veterinary Staff and Dog Owners
Authors: Oselinsky Katrina , Duncan Colleen G. , Martinez Heather E. , Graham Dan J.
Published: February 2021

Physical inactivity remains a global epidemic leading to an estimated 5 million preventable deaths per year. Although there exist numerous public-health campaigns aimed at increasing physical activity (PA), a potentially fruitful but underexplored avenue to promote both human and animal health is veterinary-prescribed PA programs. The aim of this study was to determine the feasibility and acceptability of incorporating veterinary-prescribed PA programming into a diverse array of clinic settings. Participants (n = 722 veterinary-clinic staff (VS); n = 1028 dog owners (DOs)) completed an online survey assessing: (a) the perceived importance of PA for promoting health and preventing disease, (b) willingness to participate in a veterinary-prescribed PA program, and (c) potential benefits and barriers of such a program. Both groups of participants indicated that PA is important for both human and animal health (97% and 98% of VS and 92% and 93% of DOs said PA is very or extremely important for animal and human health, respectively). Additionally, most participants in both groups expressed an interest in participating in a veterinary-prescribed PA program in the future, with only 11% of DOs and 10% of VS saying they were not interested. Benefits and barriers of this type of intervention for both practitioners and patients were also identified. Incorporating veterinary-prescribed PA programming into veterinary clinics seems to be acceptable to both DOs and VS. Additionally, many VS believe such programming would be feasible at their clinics; thus, pursuing such programs appears to be a promising avenue for promoting human and animal health.
Analysis of the Nutritional Status in Homeless People in Poland Based on the Selected Biochemical Parameters
Authors: Naszydłowska Edyta , Cedro Anna , Suliga Edyta , Kozieł Dorota , Sobaś Kamila , Jegier Anna , Głuszek Stanisław
Published: February 2021

The aim of the study was to assess the nutritional status of adult homeless people using both anthropometric and biochemical measurements. The analysis comprised anthropometric indicators, i.e., body mass index and waist circumference, and the following biomarkers: red blood cells, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, white blood cells, complete lymphocyte count, neutrophils-to-lymphocytes ratio, platelets-to-lymphocytes ratio, platelets-to-leukocytes ratio, C reactive protein level, serum iron concentration, serum albumin concentration, total serum protein, fasting lipids and blood glucose level. There were representative Polish homeless people enrolled (n = 580). The analysis of the conducted studies proved that there is a greater frequency of overweight and obesity than underweight in the target population. The major problem was abdominal obesity that was present statistically more frequently in women than men (p < 0.001). In the majority of cases, homeless people were found to have normal complete blood count parameters. In obese people, there were statistically significant both elevated and decreased hematocrit levels, a significant decrease in red blood cells, elevated serum glucose, triglycerides and total protein level (p < 0.05). The presence of abdominal obesity, elevated glucose concentration, low-density lipoprotein cholesterol, and triglycerides, and decreased high-density lipoprotein cholesterol in serum together with smoking increase the risk of cardiovascular disease.
Fit for What Purpose? Exploring Bicultural Frameworks for the Architectural Design of Acute Mental Health Facilities
Authors: Jenkin Gabrielle L. S. , McIntosh Jacqueline , Every-Palmer Susanna
Published: February 2021

Acute mental health care facilities have become the modern equivalent to the old asylum, designed to provide emergency and temporary care for the acutely mentally unwell. These facilities require a model of mental health care, whether very basic or highly advanced, and an appropriately designed building facility within which to operate. Drawing on interview data from our four-year research project to examine the architectural design and social milieu of adult acute mental health wards in Aotearoa New Zealand, official documents, philosophies and models of mental health care, this paper asks what is the purpose of the adult inpatient mental health ward in a bicultural country and how can we determine the degree to which they are fit for purpose. Although we found an important lack of clarity and agreement around the purpose of the acute mental health facility, the general underpinning philosophy of mental health care in Aotearoa New Zealand was that of recovery, and the CHIME principles of recovery, with some modifications, could be translated into design principles for an architectural brief. However, further work is required to align staff, service users and official health understandings of the purpose of the acute mental health facility and the means for achieving recovery goals in a bicultural context.
“It Is Like Medicine”: Using Sports to Promote Adult Women’s Health in Rural Kenya
Authors: Barchi Francis , AbiNader Millan A. , Winter Samantha C. , Obara Lena M. , Mbogo Daniel , Thomas Bendettah M. , Ammerman Brittany
Published: February 2021

Despite the well-documented health benefits of recreational sports, few opportunities exist in lower- and middle-income countries for adult women to participate in recreational physical activities. An explanatory sequential mixed methods approach was used to explore associations between an innovative soccer program for adult women and self-reported health status. Cross-sectional survey data were collected in 2018–2019 from 702 women in the Nikumbuke Project, a health and literacy program in southeastern rural Kenya, followed by focus group discussions with 225 women who also participated in the Project’s soccer program. Quantitative findings suggest that women who participated in soccer had 67% greater odds of reporting good or excellent health than their non-soccer playing peers. Thematic analysis of qualitative data indicated that women credited soccer with less pain, fatigue, and stress, as well as weight loss and reduced dependence on medicine for hypertension, pain, and sleep problems. Women equated health benefits with greater ease and efficiency in completing chores, reduced worries, youthful energy, male-like strength, and pleased husbands. Soccer programs for adult women may be particularly effective interventions in settings where access to health care is limited and where lack of opportunity to engage in physical aerobic activity increases women’s risks for poor health outcomes.
Combined Effects of Oligopeptides Isolated from Panax ginseng C.A. Meyer and Ostrea gigas Thunberg on Sexual Function in Male Mice
Authors: Li Di , Ren Jinwei , He Lixia , Sun Jingqin , Liu Peng , Li Yong
Published: February 2021

Male sexual debility affects patients’ confidence and damages the relationship between the couples and thus affects the stability of the family. This study aimed to investigate the effects of oligopeptides isolated from ginseng and oyster (GOPs and OOPs), separately and in combination, on sexual function in male mice. In the first experiment, male mice were randomly divided into five groups: vehicle control group; whey protein (125.0 mg kg−1) group; and GOPs 62.5, 125.0, and 250.0 mg kg−1 groups. In the second experiment, male mice were randomly divided into five groups: vehicle control group, whey protein (160.0 mg kg−1) group, and OOPs 80.0, 160.0, and 320.0 mg kg−1 groups. In the third experiment, male mice were randomly divided into six groups: vehicle control group, whey protein (222.5 mg kg−1) group, and GOPs + OOPs 62.5 + 160.0, 62.5 + 320.0, and 125.0 + 160.0, 125.0 + 320.0 mg kg−1 groups. Test substances were given by gavage once a day for 30 days. The sexual behavior parameters, serum nitric oxide (NO), testosterone, cyclic guanosine monophosphate (cGMP), and phosphodiesterase-5 (PDE5) concentrations were detected. We found that GOPs at 250.0 mg kg−1 improved male sexual behavior, NO, and testosterone content, whereas GOPs at 62.5 and 125.0 mg kg−1 and OOPs at 80.0, 160, and 320 mg kg−1 did not have significant effects. The combination of 62.5 mg kg−1 GOPs + 160.0 mg kg−1 OOPs and the combination of 125.0 mg kg−1 GOPs + 320.0 mg kg−1 OOPs improved male sexual behavior, serum NO, testosterone, and cGMP contents and decreased PDE5 content. The combination of 62.5 mg kg−1 GOPs and 160.0 mg kg−1 OOPs had the best effects among four combined groups. These results suggested that GOPs in combination with OOPs had the synergistic effects of enhancing male sexual function, probably via elevating serum testosterone, NO, and corpus cavernosum cGMP level and decreasing the corpus cavernosum PDE5 level. GOPs and OOPs could be novel natural agents for improving male sexual function.
Twitter Use in Hurricane Isaac and Its Implications for Disaster Resilience
Authors: Wang Kejin , Lam Nina S. N. , Zou Lei , Mihunov Volodymyr
Published: February 2021

Disaster resilience is the capacity of a community to “bounce back” from disastrous events. Most studies rely on traditional data such as census data to study community resilience. With increasing use of social media, new data sources such as Twitter could be utilized to monitor human response during different phases of disasters to better understand resilience. An important research question is: Does Twitter use correlate with disaster resilience? Specifically, will communities with more disaster-related Twitter uses be more resilient to disasters, presumably because they have better situational awareness? The underlying issue is that if there are social and geographical disparities in Twitter use, how will such disparities affect communities’ resilience to disasters? This study examines the relationship between Twitter use and community resilience during Hurricane Isaac, which hit Louisiana and Mississippi in August 2012. First, we applied the resilience inference measurement (RIM) model to calculate the resilience indices of 146 affected counties. Second, we analyzed Twitter use and their sentiment patterns through the three phases of Hurricane Isaac—preparedness, response, and recovery. Third, we correlated Twitter use density and sentiment scores with the resilience scores and major social–environmental variables to test whether significant geographical and social disparities in Twitter use existed through the three phases of disaster management. Significant positive correlations were found between Twitter use density and resilience indicators, confirming that communities with higher resilience capacity, which are characterized by better social–environmental conditions, tend to have higher Twitter use. These results imply that Twitter use during disasters could be improved to increase the resilience of affected communities. On the other hand, no significant correlations were found between sentiment scores and resilience indicators, suggesting that further research on sentiment analysis may be needed.