bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Pneumococcal Avidity and Antibody Concentration in Children with Recurrent Infections: A Retrospective Pilot Study
Authors: Intner Sara , Altrich Michelle , Patel Niraj
Published: February 2021

Measurement of pneumococcal antibody concentration is a frequently used parameter for functional antibody response to vaccination. Antibody concentration in response to vaccination and strength of antigen-antibody (avidity) interaction are both important measurements of functional antibody response. Both antibody concentration and avidity contribute to immunity against invasive pneumococcal disease. Higher avidity is correlated with increasing bactericidal activity and opsonophagocytosis. On the other hand, patients with lower pneumococcal avidity may be more likely to develop clinically significant pneumococcal sinopulmonary infections. Nine patients with recurrent bacterial respiratory infections were identified by retrospective chart review as having adequate pneumococcal antibody concentrations, but with low avidity for multiple serotypes following immunization with pneumococcal vaccine polyvalent (PPSV23). We assessed response with IgG replacement therapy in these patients. The mean number of serotypes with a normal antibody response (>1.3 mg/ml) among 9 children following immunization with pneumococcal vaccine polyvalent was 19.1 (range 12-22) of 23 serotypes while the mean number of serotypes with a normal avidity response (≥1.0) was 4.7 (range 2-7) of 23 serotypes. Flow cytometry was performed for 8 of the 9 patients prior to starting SCIG replacement therapy. 100% of the cohort experienced a significant decrease in yearly infection rate after starting immunoglobulin replacement. This is the first study to assess the clinical response to immune globulin replacement in patients with normal pneumococcal antibody response but poor pneumococcal avidity, and suggests that patients with poor pneumococcal avidity but apparent normal response by pneumococcal antibody following PPSV23 may benefit from IgG replacement therapy.
SARS-CoV-2 Virus and Human Leukocyte Antigen (HLA) Class II: Investigation in silico of Binding Affinities for COVID-19 Protection and Vaccine Development
Authors: Charonis Spyros , Tsilibary Effie-Photini , Georgopoulos Apostolos
Published: February 2021

SARS-CoV-2 causes COVID-19, urgently requiring the development of effective vaccine(s). Much of current efforts focus on the SARS-CoV-2 spike-glycoprotein by identifying highly antigenic epitopes as good vaccine candidates. However, high antigenicity is not sufficient, since the activation of relevant T cells depends on the presence of the complex of the antigen with a suitably matching Human Leukocyte Antigen (HLA) Class II molecule, not the antigen alone: in the absence of such a match, even a highly antigenic epitope in vitro will not elicit antibody formation in vivo. Here we assessed systematically in silico the binding affinity of epitopes of the spike-glycoprotein to 66 common HLA-Class-II alleles (frequency ≥ 0.01). We used a sliding epitope window of 22-amino-acid-width to scan the entire protein and determined the binding affinity of each subsequence to each HLA allele. DPB1 had highest binding affinities, followed by DRB1 and DQB1. Higher binding affinities were concentrated in the initial part of the glycoprotein (S1-S460), with a peak at S223-S238. This region would be well suited for effective vaccine development by ensuring high probability for successful matching of the vaccine antigen from that region to a HLA Class II molecule for CD4+ T cell activation by the antigen-HLA molecule complex.
Commentary: Trained immunity and beyond: the not-yet lost chance to win with COVID-19
Authors: Kloc Malgorzata , Ghobrial Rafik Mark , Kubiak Jacek
Published: February 2021

COVID-19 pandemic has frightened people and governments all around the world. The common opinion is that there are no efficient preventive measures but masks, isolation, and social distancing. The deliverance is hoped from the SARS-CoV-2-specific vaccine, which must be efficient and cheap. But, so far nobody knows when, and if such a vaccine will be developed and mass-produced. Trained immunity with oral polio vaccine (OPV) was recently proposed as a temporal solution against the heavy course of COVID-19. However, politics do not seem to follow, and the scientific world should react because humanity has no time to lose. Below, we support this with our thoughts.
HUBUNGAN TINGKAT PENCAHAYAAN, KELEMBABAN UDARA, DAN VENTILASI UDARA DENGAN FAKTOR RISIKO KEJADIAN TB PARU BTA POSITIF DI DESA JATIKALANG KECAMATAN KRIAN KABUPATEN SIDOARJO
Authors:   Bagian Ilmu Kesehatan Masyarakat, Fakultas Kedokteran, Universitas Wijaya Kusuma Surabaya, Sahadewa Sukma , Eufemia Eufemia ,   Fakultas Kedokteran, Universitas Wijaya Kusuma Surabaya, Edwin Edwin ,   Fakultas Kedokteran, Universitas Wijaya Kusuma Surabaya, Niluh Niluh ,   Fakultas Kedokteran, Universitas Wijaya Kusuma Surabaya, Shita Shita ,   Fakultas Kedokteran, Universitas Wijaya Kusuma Surabaya
Published: February 2021

Tuberculosis is an infectious disease caused by Mycobaterium tuberculosis which can be influenced by several factors. The physical condition of an unhealthy home environment plays an important role in the transmission and proliferation of Mycobacterium tuberculosis. The aim of the study was to analyzed the relationship between lighting levels, air humidity, and air ventilation with risk factors for positive Acid resistant bacteria pulmonary TB incidence in Jatikalang Village, Krian District, Sidoarjo Regency. The population of the cases in this study were all patients who were declared positive result of Acid resistant bacteria pulmonary tuberculosis who came to the Krian Health Center for the period January 2017 - December 2017 with a sample size of 34 respondents. The data analysis was used is the odds ratio test. The results of the analysis showed that there was a significant relationship between home ventilation and the incidence of tuberculosis with p-value = 0.006 (<0.05) and OR = 7.800 (> 1) are obtained. The result showed that poor home ventilation has a risk of 7,800 times greater to experience the incidence of pulmonary TB.
Normative und nicht normative Übergänge und Lebensereignisse im Lebenslauf und ihre Bedeutung für die Anpassung im Alter
Authors: Ferring Dieter
Published: February 2021

Der Text schlägt eine Systematik von Übergängen und Ereignissen innerhalb des Lebenslaufs vor und beschreibt deren Bedeutung für individuelle Anpassungsprozesse im Alter. Dabei werden insbesondere die Bedeutung der kognitiven Bewertung und Repräsentation solcher Ereignisse für die Selbstregulation thematisiert. In einem systemischen Ansatz wird die Bedeutung familiärer Werte für diese Wahrnehmungsund Bewertungsprozesse akzentuiert. Hier liegen auch die Potenziale für beraterisches und therapeutisches Handeln, die in der Konklusion kurz angesprochen werden.
Auseinandersetzung mit existenziellen Themen im Alter
Authors: Noyon Alexander
Published: February 2021

Im höheren Lebensalter rückt bei vielen Menschen die Auseinandersetzung mit Fragen wie jener nach dem Sinn des gelebten Lebens oder der Bedeutung des Todes in den Mittelpunkt. In der Therapie stellen solche Fragen den Therapeuten vor besondere Herausforderungen, da beispielsweise eine Problem-Lösungsorientierung versagen muss – die menschliche Sterblichkeit beispielsweise ist kein Problem, das sich lösen lässt, sondern eine gegebene Facette unserer Existenz. Die existenzielle Psychotherapie fokussiert genau auf solche Themen und versucht, bei der Auseinandersetzung mit diesen »letzten Fragen« hilfreich zu sein. Im vorliegenden Beitrag werden vier existenzielle Fragestellungen (Isolation, Freiheit, Sinnlosigkeit, Tod) diskutiert.
Wer oder was kann helfen, wenn der Patient vergessen hat, was hilft?
Authors: Wilfarth Susanne
Published: February 2021

Die Zahl der Demenzkranken in Krankenhäusern nimmt zu. Die meisten Demenzkranken leiden unter nicht-kognitiven Begleitsymptomen, die auch psychotherapeutisch behandelbar sind. Die diesbezügliche Arbeit erfordert eine Anpassung der psychotherapeutischen Maßnahmen an das spezielle Krankheitsbild. Förderliche Behandlungsansätze umfassen eine differenzierte neuropsychologische Diagnostik, Zukunftsplanung mit dem Patienten unter Einbeziehung der Angehörigen sowie Schulung des Klinikpersonals inkl. Laienhelfer.
Kreatives Vergessen
Authors: Luft Helmut
Published: February 2021

Demenz wird im öffentlichen Bewusstsein überwiegend als Damoklesschwert erlebt, das unentrinnbar alle betreffe und immer einen tragischen Verlauf nehme. Demgegenüber wird in dieser Arbeit auf gutartigere Verlaufsformen und einige tröstliche Aspekte hingewiesen.
Bedeutung, Erfahrung und Kompetenz der Gerontopsychiatrie
Authors: Gutzmann Hans
Published: February 2021

Nach einer europaweiten, repräsentativen Studie hat die Hälfte der heute Älteren im bisherigen Leben eine gravierende psychische Störung durchgemacht, ein Viertel von ihnen leidet aktuell darunter. Die Mehrheit der gerontopsychiatrischen Patienten lebt in der Kommune, unterstützt von der Familie oder professionellen Pflegediensten. Die Multidimensionalität der Problemstellungen und Versorgungsstrukturen erfordert gerontopsychiatrische Kompetenz bei der Planung und Steuerung. In der Mehrzahl der Fälle sind Hausärzte die ärztlichen Hauptversorger. Die Vorstellung, dass allgemeinpsychiatrische Angebote den spezifischen gerontopsychiatrischen Versorgungsbedarf decken, ist unrealistisch. Gerontopsychiatrische Zentren und kompetente stationäre Angebote sind als Teil der psychiatrischen Pflichtversorgung unverzichtbar. Ein Schwerpunkt Gerontopsychiatrie im Fächerkanon der Psychiatrie würde Deutschland mit internationalen Entwicklungen Schritt halten lassen.
Neue Versorgungskonzepte in der Gerontopsychiatrie und -psychotherapie
Authors: Holthoff-Detto Vjera
Published: February 2021

Zur gerontopsychiatrischen und gerontopsychotherapeutischen Behandlung gehört eine multiprofessionelle und interdisziplinäre Therapie. Veränderungen in der Mobilität und die Häufigkeit an Komorbidität sowie die im Allgemeinen notwendige Hilfe im persönlichen Alltag stellen eine besondere Herausforderung dar. Die Früherkennung ist auch im Alter unverzichtbar, da Länge und Rezidive einer Erkrankung erheblichen gesundheitlichen Schaden bei den älteren Patienten zur Folge haben. Versorgungsstrategien, die einen niedrigschwelligen und mehrstufigen Zugang zu immer spezialisierteren gerontopsychiatrischen und -psychotherapeutischen Behandlungen ermöglichen und im hausärztlichen Versorgungssektor angeboten werden, zeigen signifikante Effekte. Die aufsuchende Therapie, die somatische und psychische Erkrankungen behandelt, führt zur klinisch signifikanten Besserung bei alten Menschen mit sonst fehlendem Zugang oder fehlender Inanspruchnahme der psychiatrischen Therapie. Die telemedizinische, gerontopsychotherapeutische Behandlung kann genau wie das klassische Therapiesetting zu signifikanten Verbesserungen der psychischen Symptome führen.
Politischer »Mehrgenerationen-Stammtisch«
Authors: Kirch Sam
Published: February 2021

Das Masterstudium »Gerontological Sciences« (Altersforschung/Gerontologie) des Autors behandelte vorwiegend fachwissenschaftliche und theoretische Themen. Die Anwendung des Gelernten und das praktische Arbeiten kamen zu kurz. Daher entschied sich der Autor, eine gewisse Zeit in der Praxis mit Senioren und demenziell veränderten Menschen zu arbeiten. Im Rahmen der Tätigkeit im Seniorenzentrum initiierte er einen politischen »Stammtisch« für die Bewohner. Aufgrund seiner Erfahrungen und der Gespräche am Stammtisch kommt er zum Fazit, dass sich die Bewohner dank dieser Initiative wieder vermehrt als aktiver Teil der Gesellschaft wahrgenommen fühlen.
»Vom Schwindel zum Tanz«
Authors: Gehle Bettina
Published: February 2021

Die stationäre psychosomatisch-psychotherapeutische Behandlung psychischer und psychosomatischer Störungen stellt neben der ambulanten Psychotherapie einen beträchtlichen Anteil des Versorgungsangebotes für psychisch Kranke dar. In den psychosomatischen Akutabteilungen und -kliniken entstanden in den letzten Jahren immer mehr altersspezifische Konzepte und Stationen. Diese bieten ein therapeutisches Angebot, das altersspezifischen Regressionsformen, wie Scham und Angst, ebenso den Konfliktthemen des Alters förderlich entgegenkommt.
Neuropsychologische Aspekte der stationären psychosomatischen Behandlung älterer Patienten
Authors: Peters Meinolf
Published: February 2021

Kognitive Veränderungen wurden bislang in stationären psychosomatischen Behandlungen Älterer wenig berücksichtigt. Dieser Artikel gibt einen Überblick über empirische Befunde zu diesem Thema und referiert eine explorative Studie mit stationär aufgenommenen Patienten, bei denen Gedächtnistrainings durchgeführt und kognitive Veränderungen mit einer unbehandelten Kontrollgruppe verglichen wurden. Beide Gruppen wiesen in vergleichbarem Maße verbesserte kognitive Fähigkeiten auf, was darauf zurückgeführt wird, das bereits der klinische Aufenthalt mit den damit verbundenen kognitiven und emotionalen Herausforderungen stimulierend auf Gedächtnisfunktionen gewirkt haben könnte. Diese stimulierende Wirkung eines stationären Milieus sollte bei der Behandlung Älterer systematisch genutzt werden.
Evolución de las réplicas de arte parietal, un equipamiento museístico singular
Authors: Miró Alaix Manel
Published: February 2021

Este artículo recoge la ponencia presentada en el congreso “Retos y futuro de las réplicas de arte parietal como equipamientos museísticos" celebrado en el Balneario de Zestoa el 20 de julio de 2018, en el marco de los Cursos de Verano de la Universidad del País Vasco y de la celebración del 10º aniversario de la inauguración de Ekainberri.El artículo presenta, en primer lugar, una aproximación a la historia de las réplicas de arte parietal, en segundo lugar, plantea una reflexión sobre el sentido que tiene hacer dichas réplicas y, en tercer lugar, se interroga sobre la eficacia o no de las diferentes tipologías de réplicas que podemos encontrar hoy en día.
El traslado de la marquesina de La Rocica (Avilés, Asturias). Del estorbo a su revalorización patrimonial.
Authors: Domínguez Rodríguez Rubén
Published: February 2021

La marquesina del tranvía eléctrico situada originalmente en La Rocica (Avilés, Asturias) es una construcción adscrita al Movimiento Moderno datada en la segunda mitad de la década de los cincuenta del siglo XX, siendo el testigo más meridional de la política constructiva desarrollada por ENSIDESA conforme a sus planteamientos paternalistas.En el año 2017, esta singular construcción se vio envuelta en una polémica a raíz de su demolición, refrendada mediante una consulta popular, prevista dentro del proyecto de reurbanización de la avenida de Santa Apolonia, donde se encontraba. En este contexto, numerosas entidades científicas y ciudadanas, acompañadas de 1218 firmas, solicitaron al Ayuntamiento de Avilés la conservación del bien y, si fuese necesario para su salvaguarda, su traslado a un lugar cercano en el poblado obrero de Llaranes. Tras un largo período de tiempo, éste se hizo efectivo el 31 de octubre de 2018 dando lugar a un interesante proceso de revalorización patrimonial que será analizado en el presente artículo.
Penetration and Functioning of Anglicisms in the German Sports Discourse
Authors: Zhilyuk Sergey Alexandrovich , Meibom Viktoria Evgenevna , Rozhina Alisa Alexandrovna
Published: February 2021

The study aims to determine the impact that the English language has on the German sports discourse. Scientific novelty of the work lies in studying not the borrowings themselves, but the German sports discourse, in establishing the fact of parallel development of endogenous and exogenous lexemes on the topic “Sport”. In the course of the research, the authors have studied texts of the German mass media from 1995, 2005 and 2019, analysed increase in frequency of Anglicisms use. The attained results have shown that despite significant influence of the English language, which manifests itself primarily in texts about the American sports (baseball, basketball), the German language possesses and actively uses endogenous conceptual apparatus.
I. S. Turgenev’s Creative Work as Assessed by the Chinese Literary Criticism (1980-2010)
Authors: Li Xilu
Published: February 2021

The work aims to determine the state of studying I. S. Turgenev’s creative work in China, to provide a short overview of the lines of modern research. In this article, the author has submitted representative results of literary criticism works by the Chinese authors covering the period from 1980 to 2010. The work is novel in that it presents and systematises approaches to studying different artistic aspects of Turgenev’s creative heritage in China at the current stage. It shows development history and reflects important scientific findings of Turgenev studies in China over the last thirty years. The article identifies and thematises the main aspects in the field of studying Turgenev’s literary heritage and presents their main content features. The attained results have shown that over thirty years of working with Turgenev’s literary heritage, there have been formed independent fields of study in China, but the main bulk of research is still based on developments of the Russian and Soviet literary criticism.
Legal Regulation of the Protection of Intellectual Property Rights within the EU Digital Market
Authors: Yavorska Iryna , Boyarska Sofiya
Published: February 2021

The active usage of the technologies, constant exchange of information and its use demanded a clear regulation of relations within the functioning of the digital market. In the context of the implementation of the Association Agreements between Ukraine and the EU, it seems necessary to study the positive experience of regulating relations and protecting intellectual property rights within the European Union digital market. The article explores such EU secondary law acts as directives and regulations that determine the foundations and features of the functioning of EU digital market actors. In particular, it examined Directive (EU) 2019/789 of the European Parliament and of the Council of 17 April 2019 laying down rules on the use of copyright and related rights applicable to certain online broadcasting and retransmission of broadcasting programs and amending Council Directive 93/83 EEC (2019), which regulates the principles governing the transboundary transmission of television and radio broadcasting via the satellite network; Directive (EU) 2019/790 of the European Parliament and of the Council of 17 April 2019 on copyright and related rights in the Digital Single Market and amending Directives 96/9/EC and 2001/29/2019, which amended and expended 7 existing Directives governing relevant issues, Regulation (EU) 2019/517 of the European Parliament and of the Council of 19 March 2019 on the implementation and operation of the .eu top-level domain name and amending and repealing Regulation (EU) No 733/2002, and repealing Commission Regulation (EC) No 874/2002 (2019), which provides a number of important innovations for the .eu top-level domain name and Regulation (EU) No 2017/1128 of the European Parliament and of the Council of 14 June 2017 on the cross-border movement of Internet content services in the internal market, which identifies legitimate access to portable internet-Content. Not only when they are in their own country, but also when moving within the EU. Key words: digital market; legal regulation of EU digital market functioning; .eu top-level domain name; portable internet content; cross-border transmission.
Identification Criteria of Jus Cogens Norms in International Law
Authors: Dolinska Yuliya
Published: February 2021

The article examines the positions of leading scholars on the identification of imperative norms of international law, discusses critical remarks that focus primarily on the difficulties connected with such identification. Trying to codify the concept of jus cogens in international law, the Commission itself acknowledged that the wording of the article was not so straightforward as there was no simple criterion by which a general rule of international law could be defined as having the character of jus cogens. Moreover, most of the general rules of international law are not of this nature, and therefore States can evade them by concluding treaties. Having considered the general definition of jus cogens in the Vienna Convention, it can be argued that the rule of international law can be ‘raised’ to the status of the rule of jus cogens – the imperative rule of international law – if the latter meets all the criteria. An important criterion worth noting is that imperative rules protect the interests of the whole international community: all imperative rules protect the interests of community, but not all public interests will be protected by the rules of jus cogens. The next criterion, closely related to the previous one, is that jus cogens rules protect the most fundamental ethical values of the international community, and one more – the absolute nature of the norm. But, in fact, the jus cogens category itself has more authority than its specific content. Despite the fact that none of the documents contains a comprehensive list of rules that should be considered imperative, the article provides a preliminary classification of non-derogation rules in order to illustrate some of the most obvious and applicable jus cogens norms for indicating in these examples the general nature and scope of the rule contained in Article 53. Key words: jus cogens norms; imperative norms; international law.
Does intense electoral competition increase the government health expenditure in EAs?
Authors: Lee Jeong Woo
Published: February 2021

Does intense electoral competition in
electoral autocracies (EAs) increase the government health expenditure?
Previous studies on EAs
and public health expenditure focus on the presence of multiparty
elections in EAs as a significant determinant on the expenditure. Most of
elections in EAs often are unfair because those are for the victory of
dictators; hence. multiparty elections per se do not capture well-known
impact of elections, such as the electoral competition increasing health
expenditure. Some EAs pay health expenditure less than others even though
electoral competition is high. This paper analyzes the effect of electoral
competition on the government health expenditure with the balanced panel data
of 20 EAs from 2001 to 2017. There are two rival arguments on how electoral
competition affect the expenditure according to previous studies; (a) a high
level of electoral competition indicates
a difficulty of dictatorial winning in elections. Autocrats,
hence, gather various demands including health issues from voters, and can
increase the government health expenditure; (b) Autocrats pursue the victory in
elections. Pork and personal benefits to voters rather than programmed policies
are helpful for the victory. Therefore, there is no incentive for autocrats to
provide government health expenditure to voters when the level of electoral
competition is high. Empirical findings demonstrate that electoral competition
in EAs lead the decrease of government health expenditure. This paper concludes
that electoral competition does not increase the public health expenditure; the
higher level of competition in autocracies does not mean that voters can exert
their power to autocrats to realize policies.
Enlargement of female pupils when perceiving something cute, except for female faces
Authors: Kuraguchi Kana , Kanari Kei
Published: February 2021

It is reported that women’s pupils dilate when they
see a baby; it is unclear if this pupillary response is caused by the perception
of cuteness itself. Since many objects besides babies can be perceived as cute,
we investigated whether the perception of cuteness, or the type of object
observed, is related to pupil dilation. In the first experiment, female
participants were requested to rate the subjective cuteness of greyscale
pictures of objects such as animals and foods; their pupil sizes were measured.
The results showed a significant positive correlation between perceived
cuteness and participants’ pupil dilation. In the second experiment, participants
rated the cuteness of images of female faces. Results revealed a significant
negative correlation between perceived cuteness and pupil dilation. In our
study, perceiving cuteness enlarged female observers’ pupils except when
observing female faces. Positive reactions associated with cuteness may be
premised on the existence of unconscious perceptual alterations and physical
responses.
Barking Up the Wrong Tree: SMEs' Perception of Tax using the ZMET Method
Authors: Puspasari Novita , Herwiyanti Eliada , Pinasti Margani
Published: February 2021

Small and Medium Enterprises (SMEs) has been a backbone for Indonesian economy over the years. This study aims to explore and gain an in-depth understanding of SMEs’ perceptions regarding tax imposed by the government. The study is a qualitative investigation in which nine in-depth interviews with SMEs were conducted based on the Zaltman Metaphor Elicitation Technique (ZMET). The findings reveal deep-seated perceptions in SMEs regarding to tax imposed on them. There are 24 elicited constructs which describe SMEs’ mental model of tax. The constructs are framed into four deep metaphors which reflect SMEs perceptions on tax: Distrust to the Government, Misclassification, Mistreatment and Disincentive. This study will contribute to provide suggestion to the government, particularly General Directorate of tax, that in order to give “stick” to SMEs, government may try to give “carrots” in SMEs tax cases. This study contributes to the use of ZMET as a data collecting method to examine issues that tend to be "sensitive". Previously, ZMET has been used widely in marketing research, however this research could prove that other topics of research could also use this method
Global Collaboration at Its Purest
Authors: Pape Helpe
Published: February 2021

Global Collaboration at Its Purest / How do teenagers with passion find and work with each other?
Toward Mindsponge-ism: institutionalizing information processing in an efficient and healthy manner
Authors: Nguyen Hong-Kong T. , Ho Tung Manh
Published: February 2021

This essay suggests the need to build and nurture a healthy culture of information processing. One particular approach is to draw from the multi-filtering system of the mindsponge mechanism (Vuong, 2016; Vuong & Napier, 2015), the adoption of which could potentially move us toward a more permanent way of thinking and living: “mindsponge-ism.”
Financing Innovation: A Complex Nexus of Risk & Reward
Authors: Dutta Sourish
Published: February 2021

The crucial and growing role performed by different financial intermediaries such as venture capitalists and angel investors as well as more traditional intermediaries such as commercial banks in developing entrepreneurial or innovative firms and boosting product market innovations has led to great research interest in the economics of innovation and entrepreneurial finance. Besides this, there are some important factors or developments which have affected the entrepreneurial finance in general as well as its influence upon different entrepreneurial or innovative firms. Indeed, it is also true that the financial and ownership structures of the different entrepreneurial firms and the legal as well as the institutional environment, in which they operate, itself affects the product market innovations (Chemmanur and Fulghieri, 2014). Therefore, in this paper, I want to target a broad theme i.e. analysis of the mechanisms behind this scenario, especially, in the context of the Indian market system.
Chơi cổ phiếu không thể như... đánh lô, đề
Authors: Pape Helpe
Published: February 2021

Thị trường chứng khoán VN thời gian qua lên xuống thất thường làm nản lòng không ít nhà đầu tư không chuyên. Theo các chuyên gia, hiện tượng này có mặt tích cực khi giúp các nhà đầu tư bớt dần cảm tính, trả lại đúng bản chất của thị trường chứng khoán. Phóng viên Báo Người Lao Động đã có cuộc trao đổi với TS Vương Quân Hoàng - nghiên cứu viên cấp cao ĐH Tổng hợp Bruxelles (Bỉ) đồng thời là người sáng lập trang web hữu ích về những kiến thức kinh doanh và đầu tư www.saga.vn
Effect of ICT on Women Entrepreneur Business Performance: Case of Malaysia
Authors: Isa Filzah Md , Muhammad Nik Maheran Nik , Ahmad Azizah , Noor Shaista
Published: February 2021

Women entrepreneur has gained utmost importance in the past few decades in Malaysia due to their significant contribution to the country's economic development. However, few business challenges create a constant obstruction for many women entrepreneurs such as lack of ICT knowledge, time constraint to learn ICT, lack of technological expertise, etc. The present study aims to identify the effect of ICT adoption on business performance and examine how ICT usage helped them handle operational business matters. The present study adopted the qualitative research strategy, and researchers interviewed ten (10) women entrepreneurs for this study. A semi-structured interview technique was applied, and six Malay and four Chinese entrepreneurs made the study population. The result highlights that Malay and Chinese entrepreneurs use ICT in their business operation such as warehousing system, purchasing system, HRM software and accounting system, purchase order system, production system, internal communication, and AutoCAD. The present study may support the prospective entrepreneurs in considering the ICT usage to embark on technology and innovation and provide inputs to policymakers to design a proper support system for Malaysian women entrepreneurs, particularly those new entrepreneurs who are mostly young and inexperienced.
Aturan pembuktian tautologi
Authors: PRANATA ALDY SYURYO
Published: February 2021

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e-Babylab: An Open-source Browser-based Tool for Unmoderated Online Developmental Studies
Authors: Lo Chang Huan , Mani Nivedita , Kartushina Natalia , Mayor Julien , Hermes Jonas
Published: February 2021

The COVID-19 pandemic massively changed the context and feasibility of developmental research. This new reality as well as considerations, e.g., about sample diversity and naturalistic settings for developmental research, indicate the need for solutions for online studies. In this article, we present e-Babylab, an open-source browser-based tool for unmoderated online studies specifically targeted at studying young children and babies. e-Babylab offers an intuitive graphical user interface for study creation and management of studies, users, participant data, and stimulus material with no programming skills required. Various kinds of audiovisual media can be presented as stimuli and possible measures include webcam recordings, audio recordings, key presses, mouse-click/touch coordinates, and reaction times. Information pages, consent forms, and participant forms are all customizable. e-Babylab was used with a variety of measures and paradigms in 14 studies with children aged 12 months to 8 years (n = 1516). We briefly summarize some results of these studies to demonstrate data quality and that participants’ engagement and the overall results are comparable in lab and online settings. We then present in more detail one replication of an established preferential-looking paradigm with gaze directions manually coded from the webcam captures. Finally, we discuss useful tips for using e-Babylab and present plans for upgrades.
The Relationship between Career Success and Sense of Purpose: Examining Linkages and Changes
Authors: Weston Sara J , Cardador Teresa , Hill Patrick , Schwaba Ted , Lodi-Smith Jennifer , Whitbourne Susan
Published: February 2021

ObjectivesAlthough researchers have linked sense of purpose to working status, there are few studies examining how specific characteristics of work may correlate with sense of purpose. The aim of the current study is to extend prior research by assessing the degree to which objective and subjective forms of career success—occupational prestige and work satisfaction—are associated with levels of and changes in sense of purpose.MethodsParticipants were part of the Rochester Adult Longitudinal Study (N = 307), which contains multiple cohorts of participants each assessed at multiple waves (full age range: 42–71). We used cross-lagged modeling to test the relationships in our model.ResultsOccupational prestige was not associated with sense of purpose levels and change. However, work satisfaction was positively associated with higher levels of sense of purpose initially, and there was evidence that changes in the 2 constructs were positively correlated.DiscussionThese findings suggest that subjective career success may be more important for sense of purpose than more objective indicators. Findings are discussed with respect to study limitations and guidance for future researchers using secondary data.
Characterization of Intestinal Parasitosis in Pregant Women at Ram Janaki Hospital, Janakpurdham
Authors: Yadav Khushbu , Prakash Satyam , Yadav Basant Kumar
Published: February 2021

Objectives: The objective of this study was designed to focus the prevalence, detection and identification of intestinal parasites and its associated factors among pregnant women.

Methods: Total 264 stool samples were collected in a labeled dry, clean disinfectant free wide mouthed plastic container during antenatal visits at Ram Janaki Hospital, Janakpurdham and were examined by macroscopically and microscopically. The detection and identification of protozoal cysts, oocysts, trophozoites and helminthic eggs or larva was done by wet preparation and formalether sedimentation concentration technique. The data was analysed using SPSS 20 version and Microsoft Excel 2007. A Chi-square test was performed to predict the parasite detection using predictor variables. The p-values <0.05 was considered as significant.

Results: The prevalence of intestinal parasitosis among pregnant women was 42%. There was positive association of symptoms of intestinal parasitosis among pregnant women (p < 0.05). The most predominant intestinal parasites among study participants were E. histolytica (20%) slightly dropped by G. lamblia (16%) followed by Hook worm (13%) and A. lumbricoides (11%). The correlation between all the variables with intestinal parasites presence and absence was statistically significant (p<0.05) but statistically insignificant for age and consumption of green leafy vegetables (p>0.05).

Conclusion: The overall prevalence of intestinal parasitosis was relatively moderate. Lack of awareness, low hygienic and sanitation habits regarding parasitic infections were the major determinant factors for higher prevalence. Improving sanitation, awareness creation and public health programes should be organized at regular interval in community.
Media Framing of Bilateral Security Agreement between Afghanistan and USA
Authors: Khitab Tayyab Ur Rahman
Published: February 2021

Security in the region is one of the most important matters in international studies because it had many ups and downs during last decades. Although International Society leading U.S. sent troops to Afghanistan in order to fight against international terrorism, but still security challenges are remained the same. However, currently there is more consideration on roots of terrorism in Pakistan, but they are going to withdraw troops from Afghanistan after 2014. Some countries were pessimistic on presence of U.S. because they think U.S. has interests in Asia, controlling China, Russia and Iran. But others are worrying about future of region; especially that extremism is being expanded to the east part of China, Central Asia, and even to the south borders of Russia. Strategic agreement between Afghanistan and U.S. may have both negative and positive effects and impacts on security in the region. This research paper investigates Afghan media towards bilateral security agreement between Afghanistan and USA and its impact on regional peace and security. For this purpose, it examines the type of coverage's about security agreement get in newspapers. Content analysis of news reports from years 2014 to 2017 has done in order to know the framing of security agreement. Results reveal that media has been releasing favorable, natural and unfavorable coverage on security agreement.
ENVIRONMENTAL KUZNETS CURVE: THE CASE OF CANADA, SPAIN AND INDONESIAN ON CO2EMISSION
Authors: Erwinsyah
Published: February 2021

The Environmental Kuznets Curve is used to investigate the relationship between various indicators of environmental degradation and income per capita. The economic growth measured from the change of income per capita contributes negative externalities to nature, and education contributes to better knowledge for sustainable development. The purpose of this research was to apply the Environmental Kuznets Curve to see the impact of income per capita and education on environmental degradation. The objective of this research was to examine how GDP per capita and education contribute to per capita CO2emission in Canada, Spain, and Indonesia. The research output showed a relationship between per capita GDP with per capita CO2emission in Canada and Spain. Contribution of per capita GDP to per capita CO2emission of Canada higher than Spain. The higher per capita GDP will rise per capita CO2emission. The per capita GDP of Indonesia does did contribute significantly to per capita CO2emission. The was also a significant relationship between education quality and per capita CO2emission in Canada, Spain, and Indonesia. The better education quality in Canada and Spain contribute to lower per capita CO2 emissions. Education quality in Indonesia contributed to the higher per capita CO2emission.

Keywords:Environmental Kuznets Curve, Per Capita CO2 Emission, Per Capita GDP, Education
The Influence of Work Environment and Motivation on the Performance Oriflame Indonesia's Members
Authors: Oktora Jublina , Syamsuddin Rahmi Andini
Published: February 2021

The object of this study is to determine the impact of the work environment and motivation on the performance of members of Oriflame Indonesia. In this study, using a proportional random sampling technique, namely by using a sample of 91 respondents. Methods of data analysis using regression analysis, correlation coefficient analysis, analysis of the coefficient of determination, and hypothesis testing. Based on the partial test results for work environment variables obtained t = 2.756 with a significance value of 0.007, then Ho is rejected, and Ha is accepted. This shows that partially H1, which states that there is an influence of the work environment on performance, is accepted. Based on the partial test results for the motivation variable, it was obtained t = 3.405 with a significance value of 0.001 because the significant probability is much smaller than 0.05 then Ho is rejected, and Ha is accepted. This shows that partially H2, which states that there is an effect of motivation on performance, is accepted. Based on the test results on the F test, it is obtained that the value of F count> F table or (21.255 > 2,720), this is also reinforced by ρ value < Sig. 0.05 or (0,000 < 0.05). Thus, H0 is rejected, and H3 is accepted, this indicates that there is a positive and significant influence simultaneously between Work Environment and Motivation on the performance of Oriflame Member
Comparison of the Effectiveness 3% Tranexamic Acid Cream Versus 4% Hydroquinone Cream for Treatment of Epidermal Type Melasma
Authors: Marpaung Hartika Ketty , Theresia L. Toruan  , Yuli Kurniawati
Published: February 2021

A B S T R A C TBackground: Melasma is an acquired hypermelanosis in areas that are exposed tosun. especially in face. Severity of melasma is measured using modified MelasmaArea Severity Index (mMASI) and Melanin Index (MI). Hydroquinone (HQ) is aneffective drug and also a gold standard in terms of melasma treatment. However. thedrawback of hydroquinone is the treatment duration which is quite long. theoccurence of side effects. and also recurrence potential. Several recent studies showsthat one of the anti-pigmentation agent options. the tranexamic acid (TA). is able toprevent melanocyte activation. The results of various studies found that the use ofTA showed a significant improvement in MASI scores. Objective: To compare theeffectivity of 3% TA cream with 4% HQ cream as an alternative therapy in epidermaltype melasma treatment. Methods: A double-blind. matched. randomized clinicaltrial was conducted during July 2019 until August 2019 at Dr. Mohammad HoesinGeneral Hospital Palembang. Subjects were divided into two groups. The first group.consists of 30 participants. get 3% TA cream; and the second group. consists of 30participants. get 4% HQ cream. Subjects who fulfilled the inclusion criteria wasincluded through a simple randomization. Study subjects wer given random creampot (with label A or B on it) according to the result of simple randomization. Finally.every subjects’ melasma severity was measured using mMASI and mexameter ® .Results: There were differences in terms of baseline. 4 th weeks and 8 th weeks aftertreatment mMASI scores in 3% TA and 4% HQ group. At 8 th week. the mMASI scorethe 3% TA group was lower than 4% HQ group. There was no differences in baseline.4 th weeks and 8 th after treatment MI between the two groups. Melanin index for 3%TA group was lower than 4% HQ group. Conclusion: Three-percent TA cream and4% HQ cream is effective in decreasing mMASI score and MI in epidermal typemelasma. There were differences in terms of the mMASI score during the 8th weekafter treatment between 3% TA and 4% HQ group.
Enzyme Linked Immunosorbent Assay (ELISA) Technique Guideline
Authors: Hidayat Rachmat , Patricia Wulandari
Published: February 2021

A B S T R A C TELISA (Enzyme-linked immunosorbent assay) is a technique used to assessthe quantification of peptide, protein, antibody and hormone levels, basedon the principle of antigen-antibody binding. In the ELISA technique, antigenimmobilization will be carried out on a solid surface, then bound withantibodies to form an antigen-antibody bond complex, where the antigen-antibody complex is bound to the enzyme. The detection signal in the formof a color change will be formed due to the reaction between the enzyme andthe substrate.
Klippel Trenaunay Syndrome: A Brief Overview
Authors: Permatananda Pande Ayu Naya Kasih , I Gusti Agung Made Adnyana Putra
Published: February 2021

A B S T R A C TKlippel-Trenaunay syndrome is a rare congenital vascular disease. The pathogenesisof this syndrome is unclear, but it is thought that most cases are the result of somaticmutations that affect genes that play a role in vasculogenesis and angiogenesis. Somepatients come with a triad of capillary malformation (hemangioma or port-wine stain),venous varicosities and bony or soft tissue hypertrophy. Clinical presentation of thissyndrome can lead to significant morbidities and mortalities due to severe bleedingand emboli. Although the number of cases is low, a doctor must be able to distinguishKlippel-Trenaunay Syndrome from other rare vascular disorders. Parkes Webersyndrome is usually similar to Klippel-Trenaunay syndrome, except in the arterialmalformations associated with capillary malformations and soft tissue to skeletal orbone hypertrophy. The diagnosis of Klippel-Trenaunay Syndrome is carried outclinically and is quite difficult to do even with experienced doctors because there is noprecise pathognomonic test. There are several options in relation to the managementof Klippel-Trenaunay Syndrome and non-invasive procedure is considered to be themost important of therapy modalities. Early diagnoses, progression monitoring, andproper intervention should be carried out for better prognosis and preventingcomplication.
Ocular Lesions and Neurologic Findings in Traumatic Birds: A Retrospective Evalution of 114 Cases
Authors: DEMIR Aynur , GERBAGA OZSEMIR Kübra
Published: February 2021

This study was conducted to identify the occurrence and types of trauma-related ocular disorders in 114 birds belonging to 39 species. For this purpose, both detailed neurological examination and ophthalmologic examina-tion results of the birds admitted to our clinics with a trauma history or trauma findings are presented. Thirty cases were evaluated to suffer from trauma-related eye injuries. Uvea lesions (n=12) were the most frequent disorder of traumatic eye injury. On cranial nerve assessment, anisocoria, pupillary light reflex, menace response, globe and third eyelid position, palpebral reflex, and nystagmus were evaluated. The most frequent neurologic finding of traumatic eye injury was anisocoria (n=9). Ophthalmologic examination accompanying neurological examination is the most important fac-tor in the early management of traumatic birds.
A Influência Glocal No Movimento Worship
Authors: Dendasck Carla Viana , Ferraro Danielle
Published: February 2021

Este artigo tem como objetivo trazer uma reflexão acerca da indissolubilidade do glocal em todas as esferas do cotidiano, inclusive do contexto religioso. Para isso, utilizou-se do movimento Worship, que está ganhando cada vez mais adeptos no Brasil através da utilização mercadológica do consumo de experiência. A reflexão foi realizada através da construção do contexto glocal e dos fatores neoliberais que influenciaram a formação e o crescimento da cultura gospel. Desta forma, este estudo preconizou a influência do glocal na construção do mercado Gospel neopentecostal contemporâneo brasileiro.
ECONOMIC GLOBALIZATION’S INFLUENCE ON THE EXPORT POTENTIAL OF THE AGRO-INDUSTRIAL COMPLEX OF UKRAINE
Authors:   Prydniprovska State Academy of Civil Engineering and Architecture, Chala Veronika , Rotko Anna ,   Prydniprovska State Academy of Civil Engineering and Architecture
Published: February 2021

The article is devoted to the study of the peculiarities of the functioning of the agro-industrial complex of Ukraine in terms of international competition strengthening. The authors study the state and compliance of the development of the market of agro-industrial products of Ukraine with global trends. It is noted that the agro-industrial complex of Ukraine continues to be affected by a number of negative factors that hinder the development of the industry and do not allow to fully use all available export potential. The latest research and publications of leading economists on the development of agro-industrial production, on the problems of agricultural enterprises in foreign markets are analyzed. Ukraine is confidently increasing its position on the world market in terms of exports of agro-industrial products. However, maintaining the achieved results and reaching the leaders in new product segments require addressing the complex issue of accelerated technological development of agriculture and production, stimulating ecological certification and promoting a higher level of processing of exported products. Grounded main ways to solve them improve trends in the export of agricultural products Ukraine, formed list of measures to maximize the export potential of AIC Ukraine. It is concluded that both effective foreign economic activity of agrarian enterprises and the integration of the state to the EU depends on various issues. Provided Ukraine's foreign economic activity achieves the level of developed countries, the state will be able to take a competitive place at the world market of agricultural products and consolidate its positions. To improve the situation, it is proposed to fight corruption in the agro-industrial complex, increase the level of transparency of agribusiness in Ukraine, promote environmental certification, simplify the tax system, develop technological and innovation infrastructure of the agro-industrial complex of Ukraine and more. The proper functioning of the domestic agro-industrial market and its infrastructure as well as the financial market is a significant factor of further Ukraine's agriculture development.