bluuebunny/crossref_metadata_2025 huggingface dataset:
Solution-Focused Brief Therapy for Individuals With Alcohol Use Disorders in Chile
Authors: González Suitt Karla , Geraldo Pablo , Estay Marlene , Franklin Cynthia
Published: November 2017

Purpose:

This article presents a pilot study exploring the applicability of a linguistically adapted, solution-focused brief therapy (SFBT) program, implemented by social workers in Chilean primary care.

Method:

We completed a single-case design with eight replications. To analyze the results of the program on participants’ alcohol use and other related variables, we conducted visual and percentage of nonoverlapping data analyses.

Results:

Social workers successfully implemented 10 of the 13 SFBT techniques. Although results need to be interpreted with caution, positive trends were observed. Participants increased their “percentage of days abstinent,” diminished “consequences of alcohol use,” decreased their “depression index,” and increased their “self-reported well-being.”

Discussion:

Results are consistent with previous studies on SFBT and alcohol use. Exception and coping questions may serve to increase abstinent days. SFBT focus on issues other than alcohol that are important to clients could help to reduce harm on individuals who use alcohol.
Older, but Wiser? “The Matthew Effect” at 50: Introduction to the Dialog
Authors: Otner Sarah M. G.
Published: November 2017

Merton’s famous essay on recognition and rewards in scientific careers, “The Matthew Effect in Science”, has reached middle age. This Dialog reflects on established research that separates the origins and the consequences of status, and recent contributions regarding the constraints of status advantages. In doing so, this collection responds to a growing scholarly debate about the returns to high status. The authors engage with Merton’s cumulative status advantage, and go further to identify downsides of increased recognition both for individuals and for the status system itself. The six articles in this Dialog evaluate the progress made towards Merton’s proposed research agenda and highlight opportunities for its extension.
United States Registered Nurse Workforce Report Card and Shortage Forecast: A Revisit
Authors: Zhang Xiaoming , Tai Daniel , Pforsich Hugh , Lin Vernon W.
Published: November 2017

This is a reevaluation of registered nurse (RN) supply and demand from 2016 to 2030 using a previously published work forecast model and grading methodology with more recent workforce data. There will be a shortage of 154 018 RNs by 2020 and 510 394 RNs by 2030; the South and West regions will have higher shortage ratios than Northeast and Midwest regions. This reflects a nearly 50% overall improvement when compared with the authors’ prior study, and the low-performing states have improved from 18 “D” and 12 “F” grades as published earlier to 13 “D” and 1 “F” in this study. Although progress has been made, efforts to foster the pipelines for improving the nursing workforce need to be continued.
Teacher Reports of Verbal Aggression in School Settings Among Students With Emotional and Behavioral Disorders
Authors: Taylor Gregory G. , Smith Stephen W.
Published: November 2017

Verbal aggression (VA) is among the most prevalent forms of problem behavior in schools with detrimental effects for both perpetrators and victims, yet little is known about VA among students with emotional and behavioral disorders (EBD). Accordingly, we surveyed 279 teachers of students with behavioral disorders to examine the prevalence, frequency, locations, bystander presence and interactions, student responses, and teacher assigned consequences for verbal aggressiveness. A majority of teachers indicated daily student-to-student and student-to-adult VA with students frequently reporting, complaining, or seeking advice. Teachers noted that VA takes place in multiple locations, with at least one bystander present, and they observed victim verbal retaliation and physical assaults. Teacher responses included redirection and verbal warnings. Few teachers reported instruction of alternative prosocial behaviors. We discuss the potential implications of these findings and the impact teacher perceptions may have on strategy selection when addressing VA. We propose a few areas for future research including teachers’ level of concern about the harmfulness of VA, the intent to harm when students with EBD engage in VA, the need for specialized teacher training, and the development of a conceptual framework to inform an integrated and substantive view of the VA phenomenon.
The Effects of Family-Based Mindfulness Intervention on ADHD Symptomology in Young Children and Their Parents: A Randomized Control Trial
Authors: Lo Herman H. M. , Wong Simpson W. L. , Wong Janet Y. H. , Yeung Jerf W. K. , Snel Eline , Wong Samuel Y. S.
Published: November 2017

Objective: The aim of the study is to investigate the feasibility of a family-based mindfulness intervention in improving children with inattention and hyperactivity symptoms. Method: A total of 100 children aged 5 to 7 years with ADHD symptoms and their parents were randomly assigned to a family-based mindfulness intervention ( n = 50) or a wait-list control group ( n = 50). Results: Families from intervention group had greater improvements in children’s ADHD symptoms, with medium effect sizes of −0.60 for inattention and −0.59 for hyperactivity; overall behaviors; and parenting stress and well-being than those in wait-list control group. Conclusion: The positive results on the child primary outcome measures have provided initial evidence of the family-based mindfulness intervention as a treatment option to ADHD. The reduction of parental stress and increase in psychological well-being has demonstrated the value of mindfulness in enhancing parent’s self-management.
The digital outcry: What incites participation behavior in an online firestorm?
Authors: Johnen Marius , Jungblut Marc , Ziegele Marc
Published: November 2017

Brands, celebrities, or politicians are increasingly facing enormous online outrages in response to moral misconducts. These online firestorms are characterized by high message volume, indignant tonality, and negative opinion climate. Based on the concept of moral panics, this article analyzes why people join online firestorms. We argue that participation behavior is driven by a moral compass and a desire for social recognition. Results of an experiment and a content analysis of user comments show that a higher number of participants decreases users’ willingness to participate but fosters compliance with the prevalent opinion and tonality of the comments. We also observe that a higher moral arousal of the issue increases perceived similarity with previous participants, which in turn affects whether and how people participate. In total, our results indicate the importance of social context for participation behavior in an online firestorm.
Mass spectrometric characterization of protein structures and protein complexes in condensed and gas phase
Authors: Yefremova Yelena , Danquah Bright D , Opuni Kwabena FM , El-Kased Reham , Koy Cornelia , Glocker Michael O
Published: November 2017

Proteins are essential for almost all physiological processes of life. They serve a myriad of functions which are as varied as their unique amino acid sequences and their corresponding three-dimensional structures. To fulfill their tasks, most proteins depend on stable physical associations, in the form of protein complexes that evolved between themselves and other proteins. In solution (condensed phase), proteins and/or protein complexes are in constant energy exchange with the surrounding solvent. Albeit methods to describe in-solution thermodynamic properties of proteins and of protein complexes are well established and broadly applied, they do not provide a broad enough access to life-science experimentalists to study all their proteins' properties at leisure. This leaves great desire to add novel methods to the analytical biochemist's toolbox. The development of electrospray ionization created the opportunity to characterize protein higher order structures and protein complexes rather elegantly by simultaneously lessening the need of sophisticated sample preparation steps. Electrospray mass spectrometry enabled us to translate proteins and protein complexes very efficiently into the gas phase under mild conditions, retaining both, intact protein complexes, and gross protein structures upon phase transition. Moreover, in the environment of the mass spectrometer (gas phase, in vacuo), analyte molecules are free of interactions with surrounding solvent molecules and, therefore, the energy of inter- and intramolecular forces can be studied independently from interference of the solvating environment. Provided that gas phase methods can give information which is relevant for understanding in-solution processes, gas phase protein structure studies and/or investigations on the characterization of protein complexes has rapidly gained more and more attention from the bioanalytical scientific community. Recent reports have shown that electrospray mass spectrometry provides direct access to six prime protein complex properties: stabilities, compositions, binding surfaces (epitopes), disassembly processes, stoichiometries, and thermodynamic parameters.
Subsequent radical fragmentation reactions of N,N-diethylamino-substituted azobenzene derivatives in a Fourier transform ion cyclotron resonance mass spectrometer using collision-induced dissociation and photodissociation
Authors: Clemen Martin , Grotemeyer Jürgen
Published: November 2017

The fragmentation behavior of N, N-diethylamino-substituted azobenzene derivatives is investigated by high-resolving mass spectrometry using a Fourier transform ion cyclotron resonance mass spectrometer. Former investigations by photodissociation as well as collision-induced dissociation experiments used to induce a loss of C3H8 from the diethylamino group. The position of the additional proton in [M + H]+ ions is important due to the sequences of radical fragmentation reactions. Two possibilities arise. First, a charge is located at the azo group leading to a methyl radical loss. The second possibility is that the charge has been located on the aniline nitrogen of the molecule resulting in an ethyl radical loss. Only o-ethyl red has shown the overall loss of C3H8 in a two-step radical reaction mechanism. Nevertheless, p-ethyl red and ethyl yellow have shown systematic fragmentation reactions as well. Loss of C3H8 has not been likely regarding both these molecules. All experimental findings together with quantum chemical calculations as well as kinetic calculations support the proposed fragmentation mechanisms of the three azo dyes.
Evaluation of calculated negative mode ion mobilities of small molecules in air
Authors: Gunzer Frank
Published: November 2017

Ion mobility spectrometry is a well-known technique employed for the detection and analysis of gaseous substances. In pharmaceutical applications, it is furthermore used for structural analysis of compounds, especially in combination with mass spectrometry. In this field, the comparison of calculated collision cross sections and ion mobilities of theoretic model compounds with experimental values measured with ion mobility spectrometers helps to determine the compound’s structure. For positive mode ion mobility spectrometry, the calculated mobilities using the Trajectory Method show in general a deviation of 10% or less from experimental values. In this article, it was analyzed how well the calculated values reproduce the experimental values obtained with negative mode ion mobility spectrometry including symmetric and asymmetric analyte clusters. Furthermore, the influence of four different partial charge models on the results was investigated.
Hyperglycaemia and the SOAR stroke score in predicting mortality
Authors: McCall Stephen J , Alanazi Turkiah A , Clark Allan B , Musgrave Stanley D , Bettencourt-Silva Joao H , Bachmann Max O , Metcalf Anthony K , Bowles Kristian M , Mamas Mamas A , Potter John F , Myint Phyo K
Published: November 2017

Background:

We assessed the association between admission blood glucose levels and acute stroke mortality and examined whether there was any incremental value of adding glucose status to the validated acute stroke mortality predictor – the SOAR (stroke subtype, Oxford Community Stroke Project classification, age, and pre-stroke modified Rankin) score.

Methods:

Data from Norfolk and Norwich University Hospital stroke and Transient Ischaemic Attack register (2003–2013) and Anglia Stroke Clinical Network Evaluation Study (2009–2012) were analysed. Multivariable logistic regression analysis assessed the association between admission blood glucose levels with inpatient and 7-day mortality. The prognostic ability of the SOAR score was then compared with the SOAR with glucose score.

Results:

A total of 5575 acute stroke patients (ischaemic stroke: 89.2%) with mean age (standard deviation) of 76.97 ( ± 11.88 ) years were included. Both borderline hyperglycaemia (7.9–11.0 mmol/L) and hyperglycaemia (>11.0 mmol/L) when compared to normoglycaemia (4.0–7.8 mmol/L) were associated with both 7-day and inpatient mortality after controlling for sex, age, Oxford Community Stroke Project classification and pre-stroke modified Rankin score. Both the SOAR stroke score and SOAR-G score were good predictors of inpatient stroke mortality [area under the curve: 0.82 (95% confidence interval: 0.81–0.84) and 0.83 (95% confidence interval: 0.81–0.84)], respectively. These scores were also good at predicting outcomes in both patients with and without diabetes.

Conclusion:

High blood glucose levels at admission were associated with worse acute stroke mortality outcomes. The constituents of the SOAR stroke score were good at predicting mortality after stroke.
Investigation Into the Optimal Number of Intercostal Nerve Transfers for Musculocutaneous Nerve Reinnervation: A Systematic Review
Authors: Leland Hyuma A. , Azadgoli Beina , Gould Daniel J. , Seruya Mitchel
Published: November 2017

Background: The purpose of this study was to systematically review outcomes following intercostal nerve (ICN) transfer for restoration of elbow flexion, with a focus on identifying the optimal number of nerve transfers. Methods: A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines to identify studies describing ICN transfers to the musculocutaneous nerve (MCN) for traumatic brachial plexus injuries in patients 16 years or older. Demographics were recorded, including age, time to operation, and level of brachial plexus injury. Muscle strength was scored based upon the British Medical Research Council scale. Results: Twelve studies met inclusion criteria for a total of 196 patients. Either 2 (n = 113), 3 (n = 69), or 4 (n = 11) ICNs were transferred to the MCN in each patient. The groups were similar with regard to patient demographics. Elbow flexion ≥M3 was achieved in 71.3% (95% confidence interval [CI], 61.1%-79.7%) of patients with 2 ICNs, 67.7% (95% CI, 55.3%-78.0%) of patients with 3 ICNs, and 77.0% (95% CI, 44.9%-93.2%) of patients with 4 ICNs ( P = .79). Elbow flexion ≥M4 was achieved in 51.1% (95% CI, 37.4%-64.6%) of patients with 2 ICNs, 42.1% (95% CI, 29.5%-55.9%) of patients with 3 ICNs, and 48.4% (95% CI, 19.2%-78.8%) of patients with 4 ICNs ( P = .66). Conclusions: Previous reports have described 2.5 times increased morbidity with each additional ICN harvest. Based on the equivalent strength of elbow flexion irrespective of the number of nerves transferred, 2 ICNs are recommended to the MCN to avoid further donor-site morbidity.
Evaluation for shunted pouches of cavernous sinus dural arteriovenous fistula and the treatment outcome of transvenous embolization
Authors: Sato Masaki , Izumi Takashi , Matsubara Noriaki , Nishihori Masahiro , Miyachi Shigeru , Wakabayashi Toshihiko
Published: November 2017

Background

This study aimed to evaluate the detailed location and the number (single or multiple) of cavernous sinus dural arteriovenous fistula (CSDAVF) shunted pouches as well as the relationship between the characteristics of shunted pouch(es) and the treatment outcome of transvenous embolization for CSDAVF.

Methods

A total of 23 consecutive patients with CSDAVFs who underwent angiogram and transvenous embolization were retrospectively analyzed. Shunted pouches were assessed using three-dimensional angiogram and multiplanar reformatted image obtained from the rotational angiogram data.

Results

Of the 23 patients with CSDAVFs, 40 shunted pouches were identified. Twelve CSDAVFs had a single shunted pouch, and 11 had multiple shunted pouches. The mean CSDAVF with multiple shunted pouches was 2.5. The shunted pouches were more often found in the posterior compartment of the CS, which was connected with the intercavernous sinus (23/40; 57.5%). In 12 CSDAVFs with a single shunted pouch, 10 were treated with selective embolization and complete occlusion was achieved during the follow-up. Two CSDAVFs with single shunted pouch were just observed without intervention, and DAVFs disappeared spontaneously during the follow-up period. In 11 CSDAVFs with multiple shunted pouches, eight were treated with selective embolization and three with sinus embolization. In six of eight (75%), complete occlusion was achieved following selective embolization, but two of eight (25%) recurred and required retreatment.

Conclusions

Rotational angiography data suggested that the shunted pouches of CSDAVFs were mostly located in the posterior compartment of the CS connected with the intercavernous sinus. Selective embolization for CSDAVFs with a single shunted pouch is the first-line treatment alternative to sinus packing, and selective embolization with multiple shunted pouches will be a considerable treatment option.
Building Taiwanese history and memory from below: The role of social movements
Authors: Salmenkari Taru
Published: November 2017

Social movements use memories not only to inspire and mobilize movements but also to struggle for justice. Using memory tools, Taiwanese social movements have challenged official interpretations of history, pluralized subjects worth having their own history and democratized the process of demanding that certain memories should be preserved. They have used memory to fight for social justice and for Taiwanese traditions against modernization and globalization. Social movements have used various memory tool kits, depending on their causes, understandings of Taiwanese identity, current social struggles and access to the political process. Different memory tool kits have led social movements to interpret differently which injustices matter and which gaps in hegemonic narratives deserve their attention.
Early social communicative skills as predictors of symptom severity in autism spectrum disorder
Authors: Lobban-Shymko Jan , Im-Bolter Nancie , Freeman Nancy
Published: November 2017

Background and aims

Early diagnosis of autism spectrum disorder, while providing many benefits, also presents challenges. Accurately predicting symptom severity allows clinicians to confidently diagnose and assign the most appropriate intervention. Little available research predicts symptom severity in children with autism spectrum disorder who have not been exposed to significant levels of intervention.

Methods

The present file review study examined preverbal skills as predictors of symptom severity, approximately one year later, in a group of young children (18–64 months) with autism spectrum disorder ( n = 199).

Results

Of the two core diagnostic features (social communicative deficits and restricted repetitive behaviors), social communicative skills best predicted symptom severity. Furthermore, social communicative gestures predicted symptom severity after age, adaptive behavior, restricted repetitive behaviors, and functional gestures had been accounted for.

Conclusions

Social communicative gestures are excellent predictors of future symptom severity independent of intervention effects in very young children with autism spectrum disorder.

Implications

Previously, the social aspect of gestures has been missing in the literature on language and symptom prediction in children with autism spectrum disorder. Careful attention to social communicative gestures in the future may help with early diagnosis and more accurate predictions of symptom and developmental trajectories.
A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations
Authors: Yamaura Takeshi , Nakatani Toshiyuki , Uda Ken , Ogura Hayato , Shin Wigyon , Kurokawa Naoya , Saito Koichi , Fujikawa Norie , Date Tomomi , Takasaki Masaru , Terada Daisuke , Hirai Atsushi , Akashi Akimi , Chen Fangli , Adachi Yoshiya , Ishikawa Yuichi , Hayakawa Fumihiko , Hagiwara Shinji , Naoe Tomoki , Kiyoi Hitoshi
Published: November 2017

Key Points

FF-10101 has selective and potent inhibitory activities against FLT3 by forming a covalent bond to the C695 residue. FF-10101 shows high efficacy against AML cells with FLT3 mutations including quizartinib-resistant activation loop mutations.
Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria
Authors: Claushuis Theodora A. M. , de Vos Alex F. , Nieswandt Bernard , Boon Louis , Roelofs Joris J. T. H. , de Boer Onno J. , van ’t Veer Cornelis , van der Poll Tom
Published: November 2017

Key Points

GPVI aids in local immunity in gram-negative pneumonia–derived sepsis. GPVI, CLEC2, and neutrophils do not play a major role in vascular integrity during pneumosepsis.
Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL
Authors: Degryse Sandrine , Bornschein Simon , de Bock Charles E. , Leroy Emilie , Vanden Bempt Marlies , Demeyer Sofie , Jacobs Kris , Geerdens Ellen , Gielen Olga , Soulier Jean , Harrison Christine J. , Constantinescu Stefan N. , Cools Jan
Published: November 2017

Key Points

One-third of T-ALL cases with JAK3 mutation harbor 2 JAK3 mutations. Double JAK3 mutants show stronger signaling than single JAK3 mutants.
Role of blue dye for sentinel lymph node detection in early endometrial cancer
Authors: Restaino Stefano , Ronsini Carlo , Finelli Angelo , Perrone Emanuele , Scambia Giovanni , Fanfani Francesco
Published: November 2017

Background

Sentinel Lymphonode analysis has become a barely new and innovative way to treat early stages of endometrial cancer (Ballester et al., Lancet Oncol 469–476, 2011; Buda et al., Ann Surg Oncol 2975-81, 2016). Indocyanine green cervical injection is considered gold standard for mapping nodes’ drainage. Blue dye is used as a valid alternative in many centers, due to the lower cost of execution. The objective of this video is to prove that methylene blue dye’s cervical injection is a valid and “low-cost” method to obtain mapping of lymphatic drainage in patient with early endometrial cancer.

Methods

Fifty-four-year old women, with a recent diagnosis of endometrial cancer IA G2, we performed a radical Hysterectomy type A. We diluted in equal proportions the blue dye and saline and injected 1 cl in depth and 1 cl on the surface of the cervix, at 3 o’clock and 9 o’clock. After 20 min, it was shown with precision the lymphatic drainage until the first lymph node station from both sides.

Results

One external iliac lymph node and one obturator were resected on the left side and one external iliac on the right side. On histological analysis, none of the lymph nodes had any location of metastasis, neither micro-metastasis. Myometrial infiltration was 8/19 mm.

Conclusions

Blue dye cervical injection is a “low-cost”, safe, and satisfactory procedure to point out Sentinel Lymph Node of uterus drainage. Other tracers, such as indocyanine green, are widely used in gynecological oncology, but with a higher cost of the product and the needing of a dedicated optical filter to be shown on human view.
Yeast Hog1 proteins are sequestered in stress granules during high-temperature stress
Authors: Shiraishi Kosuke , Hioki Takahiro , Habata Akari , Yurimoto Hiroya , Sakai Yasuyoshi
Published: November 2017

The yeast high-osmolarity glycerol (HOG) pathway plays a central role in stress responses. It is activated by various stresses, including hyperosmotic stress, oxidative stress, high-temperature stress and exposure to arsenite. Hog1, the crucial MAP kinase of the pathway, localizes to the nucleus in response to high osmotic concentrations, i.e. high osmolarity; but, otherwise, little is known about its intracellular dynamics and regulation. By using the methylotrophic yeast Candida boidinii, we found that CbHog1-Venus formed intracellular dot structures after high-temperature stress in a reversible manner. Microscopic observation revealed that CbHog1-mCherry colocalized with CbPab1-Venus, a marker protein of stress granules. Hog1 homologs in Pichia pastoris and Schizosaccharomyces pombe also exhibited similar dot formation under high-temperature stress, whereas Saccharomyces cerevisiae Hog1 (ScHog1)-GFP did not. Analysis of CbHog1-Venus in C. boidinii revealed that a β-sheet structure in the N-terminal region was necessary and sufficient for its localization to stress granules. Physiological studies revealed that sequestration of activated Hog1 proteins in stress granules was responsible for downregulation of Hog1 activity under high-temperature stress.

This article has an associated First Person interview with the first author of the paper.
Learning to starve: impacts of food limitation beyond the stress period
Authors: McCue Marshall D. , Terblanche John S. , Benoit Joshua B.
Published: November 2017

Starvation is common among wild animal populations, and many individuals experience repeated bouts of starvation over the course of their lives. Although much information has been gained through laboratory studies of acute starvation, little is known about how starvation affects an animal once food is again available (i.e. during the refeeding and recovery phases). Many animals exhibit a curious phenomenon – some seem to ‘get better’ at starving following exposure to one or more starvation events – by this we mean that they exhibit potentially adaptive responses, including reduced rates of mass loss, reduced metabolic rates, and lower costs of digestion. During subsequent refeedings they may also exhibit improved digestive efficiency and more rapid mass gain. Importantly, these responses can last until the next starvation bout or even be inherited and expressed in the subsequent generation. Currently, however, little is known about the molecular regulation and physiological mechanisms underlying these changes. Here, we identify areas of research that can fill in the most pressing knowledge gaps. In particular, we highlight how recently refined techniques (e.g. stable isotope tracers, quantitative magnetic resonance and thermal measurement) as well as next-generation sequencing approaches (e.g. RNA-seq, proteomics and holobiome sequencing) can address specific starvation-focused questions. We also describe outstanding unknowns ripe for future research regarding the timing and severity of starvation, and concerning the persistence of these responses and their interactions with other ecological stressors.
Considerations on the role of olfactory input in avian navigation
Authors: Wiltschko Roswitha , Wiltschko Wolfgang
Published: November 2017

A large amount of data documents an important role of olfactory input in pigeon navigation, but the nature of this role is not entirely clear. The olfactory navigation hypothesis assumes that odors are carrying essential navigational information, yet some recent experiments support an activating role of odors. This led to an ongoing controversy. An important, often-neglected aspect of the findings on olfaction is that olfactory deprivation affects avian navigation only at unfamiliar sites. The orientation of anosmic birds at familiar sites remains an enigma; earlier assumptions that they would rely on familiar landmarks have been disproven by the home-oriented behavior of anosmic pigeons additionally deprived of object vision, which clearly indicated the use by the birds of non-visual, non-olfactory cues. However, if odors activate the establishing and enlarging of the navigational ‘map’ and promote the integration of local values of navigational factors into this map, it seems possible that such a process needs to occur only once at a given site, when the birds are visiting this site for the first time. If that were the case, the birds could interpret the local factors correctly at any later visit and orient by them. This hypothesis could explain the oriented behavior of birds at familiar sites, and it could also help to reconcile some of the seemingly controversial findings reported in the literature, where the effect of olfactory deprivation was reported to differ considerably between the various pigeon lofts, possibly because of different training procedures.
Development of UV-Curable Resins Suitable for Reverse-Tone Lithography for Au Metamaterials Using a Print-and-Imprint Method
Authors: Uehara Takuya , Sato Shinya , Ito Shunya , Yano Haruna , Nakamura Takahiro , Nakagawa Masaru
Published: November 2017

We developed a UV-curable resin (NL-SU1) suitable for screen printing with laser-drilled polyimide masks and reverse-tone nanoimprint lithography. The viscosity of the UV-curable resin composed of two bisphenol A-based monomers was adjusted to 11.0 Pa·s for the screen printing process. It was determined by photo-differential scanning calorimetry that photoinitiator Irgacure 369 was suitable for high methacrylate consumption in UV curing. The UV-curable resin after curing could be used as a top-coated resist layer on another imprinted resist layer because of its sufficient contrast in oxygen reactive ion etching and argon ion milling. We demonstrated a method for reverse-tone lithography in a print–and-imprint method to fabricate 20-nm-thick and 50-nm-linewide Au split-ring resonator arrays.
Two-Dimensional Array ATP/ADP Sensitive Image Sensor with a Uniform Distribution of Chemically Immobilized Apyrase
Authors: Endo Shinnosuke , Kato Ryo , Sawada Kazuaki , Hattori Toshiaki
Published: November 2017

ATP and ADP are the major energy source in metabolism of cells, and furthermore ATP works as an important extracellular signaling material. ATP bioimaging is required to understand their metabolism. In this paper, a label-free ATP/ADP image sensor was fabricated using a 128 × 128 (16 k) pixel array semiconductor CCD-type pH image sensor and Apyrase. The principle is based on measuring protons produced by the enzyme reaction between Apyrase and ATP or ADP. In order to put a uniform potential response of the sensor into practice, two different methods, (3-APTES and CEST), which chemically fixed N-terminal of Apyrase with the sensor were examined. The sensor modified by the CEST method had a quite clean surface microscopically and demonstrated a fine real-time image monitoring the ATP concentration. The potential response of the image sensor was characterized; effect of buffer solution, calibration curves of ATP and ADP, durability, the limit of detection (LOD) for ATP, and the response of time. The potential distribution for effective pixels to ATP concentration was narrow, single and symmetrical. Due to 16 K sensing pixels finely responding to ATP concentration uniformly, the LOD of ATP concentration (10 µM) was exactly determined with a statistical treatment.
RNA2DMut: a web tool for the design and analysis of RNA structure mutations
Authors: Moss Walter N.
Published: November 2017

With the widespread application of high-throughput sequencing, novel RNA sequences are being discovered at an astonishing rate. The analysis of function, however, lags behind. In both thecis- andtrans-regulatory functions of RNA, secondary structure (2D base-pairing) plays essential regulatory roles. In order to test RNA function, it is essential to be able to design and analyze mutations that can affect structure. This was the motivation for the creation of the RNA2DMut web tool. With RNA2DMut, users can enter in RNA sequences to analyze, constrain mutations to specific residues, or limit changes to purines/pyrimidines. The sequence is analyzed at each base to determine the effect of every possible point mutation on 2D structure. The metrics used in RNA2DMut rely on the calculation of the Boltzmann structure ensemble and do not require a robust 2D model of RNA structure for designing mutations. This tool can facilitate a wide array of uses involving RNA: for example, in designing and evaluating mutants for biological assays, interrogating RNA–protein interactions, identifying key regions to alter in SELEX experiments, and improving RNA folding and crystallization properties for structural biology. Additional tools are available to help users introduce other mutations (e.g., indels and substitutions) and evaluate their effects on RNA structure. Example calculations are shown for five RNAs that require 2D structure for their function: the MALAT1 mascRNA, an influenza virus splicing regulatory motif, the EBER2 viral noncoding RNA, the Xist lncRNA repA region, and human Y RNA 5. RNA2DMut can be accessed athttps://rna2dmut.bb.iastate.edu/.
Economies of Scale and Scope in the Sanitation Sector
Authors: Lucinda Claudio Ribeiro , Anuatti Francisco
Published: November 2017

A recente crise de abastecimento em São Paulo mostrou a importância da regulação no setor de saneamento no Estado de São Paulo. Neste sentido, o presente artigo busca auxiliar o desenho de regulação no sentido de verificar a existência de economias de escala e de escopo no setor de saneamento em São Paulo. Para tanto, foi construída uma base de dados a partir de dados internos da SABESP, combinados com dados operacionais extraídos do SNIS. Com esta base de dados foi utilizada a metodologia de Evans e Heckman, para a avaliação de economias de escala e de escopo. Os resultados nos permitem concluir que a existência de deseconomias de escala é algo extremamente raro nas cidades atendidas pela SABESP, sendo que quase todas apresentam valores negativos para a estatística SC -- o que indica que o custo de produção dos serviços de água e esgoto, nos níveis observados, é mais economicamente oferecido no âmbito de uma empresa do que em duas empresas separadas. No entanto, as evidências são mais fracas com relação às economias de escopo. Mas mesmo assim, na grande maioria das cidades atendidas pela SABESP, é mais barato o fornecimento dos serviços de água e esgoto conjuntamente dentro de uma empresa do que a separação em duas empresas focadas em diferentes serviços.Tendo em vista os resultados, podemos concluir que iniciativas que visem à separação estrutural de operadoras de água integradas tendem a gerar ineficiências do lado produtivo, fazendo com que o fornecimento dos serviços seja menos econômico.
Another Look at Panel Estimates of the Elasticity of Substitution between Capital and Labor
Authors: Mello Marcelo de Albuquerque e
Published: November 2017

We construct a broad panel with aggregate data for 94 countries over the period 1970-2014 from the latest version of the Penn World Tables (PWT) dataset, version 9.0. We estimate the elasticity of substitution between capital and labor based on the linearization of a Constant Elasticity of Substitution (CES) production function. In our preferred econometric specification, we find estimates of the elasticity of substitution that are below one. We obtain the same result when we correct the variables for cross-country differences in human capital. Additionally, estimation of a linearized CES for alternative panels constructed with data from older versions of the PWT corroborate our initial estimates. The finding that the elasticity of substitution is below one casts doubts on the Cobb-Douglas assumption commonly adopted in development accounting exercises, as well as on the recent literature on declining labor shares which assumes that the elasticity of substitution is above one.
Lei inconstitucional e Emenda Constitucional Superveniente
Authors: Mello Celso Antônio Bandeira de
Published: November 2017

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Licitação - Edital - Alteração
Authors: Martins Peçanha
Published: November 2017

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Mandado de segurança - Processo legislativo - Legitimidade ativa
Authors: Mello Celso Antônio Bandeira de
Published: November 2017

- O processo legislativo é suscetível de controle pelo Poder Judiciário havendo possibilidade de lesão à ordem jurídico-constitucional.- A legitimidade ativa é privativa de membro do Congresso Nacional, não cabendo a terceiros.
Tribunal eleitoral - Presidência - Mandato
Authors: Tácito Caio
Published: November 2017

- É vedada reeleição para Presidência do Tribunal Regional Eleitoral.- Não cabe reeleição para completar mandato em curso.
Desapropriação e população de baixa renda
Authors: Azevedo Eurico de Andrade
Published: November 2017

I. Desapropriação - 2. Imissão de posse - 3. Benfeitorias em terrenospúblicos e de terceiros - 4. Indenização - 5. Possibilidade independentementede prova de domínio - 6. Cautelas necessárias.
Tribunal de Contas Estadual - Escolha de membros - Competência
Authors: Brindeiro Geraldo
Published: November 2017

- Ação direta de inconstitucionalidade. Tribunal de Contas. Incisos I e II do § 2º, e 3º, do artigo 61 Constituição do Estado de Santa Catarina. - Já se firmou nesta Corte o entendimento - assim, a título exemplificativo, nas ADINs 219 e 419 - de que, em virtude da expressão "no que couber" contida no artigo 75 da Constituição Federal, nos Estados em que o Tribunal de Contas for composto por sete Conselheiros, e, portanto, não for possível aritmeticamente a adoção do modelo federal da terça parte, ao Governador caberá escolher três deles: um dentre auditores e outro dentre membros do Ministério Público, alternadamente, e um terceiro a seu critério. Ação direta julgada procedente, para declarar a inconstitucionalidade dos incisos I e II do § 2º, e do § 3°, do artigo 61 da Constituição do Estado de Santa Catarina.
Proibição de estacionamento de veículo - Inconstitucionalidade - Medida cautelar
Authors: Nóbrega Haroldo Ferraz da
Published: November 2017

Medida cautelar em ação direta de inconstitucionalidade. art. 2°. e seus §§ 1°. e 2°. da Lei n°. 4.771, de 16.12.92, do estado do Espírito Santo, que proíbe a cobrança ao usuário de estacionamento em área privada, nas condições em que estipula. Presença da relevância da fundamentação jurídica do pedido, vista tantona evidente inconstitucionalidade formal da lei impugnada, por invasão da competência exclusiva da União para legislar sobre direito civil (CF,  artigo 22, I), como na inconstitucionalidade material, por ofensa ao direito de propriedade (CF, artigo 5ª, XXII). 2. Presença, também, da conveniência da concessão da medida liminar pelos tumultos que a norma impugnada vem causando ao impedir o exercício de profissão lícita. 3. Precedentes: ADIMC n° 1.472-DF e ADIMC n° 1.623-RJ. 4. Medida cautelar concedida para suspender a eficácia, com efeito ex nunc, do art. 2ª e seus parágrafos § 1ª e § 2ª da Lei nª 4.711, de 16.12.92, do Estado do Espírito Santo, até o final julgamento desta ação.
Proibição de estacionamento de veículo - Prova ilícita - Inconstitucionalidade
Authors: Pereira Miguel Frauzino
Published: November 2017

"I. Interceptação telefônica: prova ilícita, salvo "autorização judicial para fins de investigação criminal ou instrução processual penal", a qual, porém, só se tornou admissível a partir da Lei 9.296/96, que lhe enumerou as hipóteses e a forma, como reclamado pelo art. 5º, Xl/, da Constituição: jurisprudência consolidada do Supremo Tribunal (HHCC 69.912, 73.351, 78.588). II. Prova ilícita: da regra constitucional de sua exclusão do processo resulta - segundo decisões majoritárias do STF (HHCC 69.912, 73.351, 78.588), a última, por maioria absoluta - a contaminação das provas dela derivadas (jruits of the poisonous tree) e a invalidação da sentença que as tenha por fundamento necessário: a exclusão da prova ilícita e de suas derivações, contudo, não afeta a validade da sentença condenatória, de cujo contexto lógico se possa afirmar a suficiência das provas legítimas e daquelas independentes.
Interrogatório - Direito de silêncio - Efeitos
Authors: Mello Celso Antônio Bandeira de
Published: November 2017

- O direito ao silêncio, previsto no art. 5º, n. LXIII, da Constituição, não importa em qualquer conclusão desfavorável à pessoa que invoca ou se vale da cláusula de tutela.
Servidor público - Vantagens - Direito adquirido
Authors: Batista Wagner Natal
Published: November 2017

Servidores públicos federais: Celetistas convertidos em estatutários. Direito adquirido a anuênio e licença-prêmio por assiduidade: artigos 67, 87 e 100 da Lei n° 8.112/90. 1nconstitucionalidade dos Incisos I e 11I do art. 71! da Lei na. 8.162, de 08.01.1991. 1. São inconstitucionais os incisos I e 1I1 do art. 7a. da Lei na. 8.162, de 08.01.1991, porque violam o direito adquirido (art. 51!, XXXVI, da c.F.) dos servidores que, por força da Lei nª 8. 112/90, foram convertidos de celetistas em estatutários, já que o art. 100 desse diploma lhes atribuíra o direito à contagem do tempo de serviço público para todos os efeitos, inclusive, portanto, para o efeito do adicional por tempo de serviço (art. 67) e da licença-prêmio (art. 87). 2. Precedentes do Plenário e das Turmas. 3. R.E. conhecido e provido, para o restabelecimento da sentença de 1° grau, que julgou procedente a ação.
As organizações sociais e as organizações da sociedade civil de interesse público
Authors: Ferreira Sérgio de Ándrea
Published: November 2017

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Dez anos de Constituição : em torno das cláusulas da inamovibilidade
Authors: Bulos Uadi Lammêgo
Published: November 2017

1. Do núcleo irreformável da constituição - 2. Da promulgação à ineficácia social - 3. Da ineficácia social ao 'reformismo' - 4. Da miniconstituinte à fraude constitucional - 5. Da conclusão.
Ação direta de inconstitucionalidade - Emenda Constitucional superveniente - Prejudicialidade
Authors: Brindeiro Geraldo
Published: November 2017

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Servidor público - Exoneração - Retorno
Authors: Macedo Wilson Teles de
Published: November 2017

- O servidor público não tem direito por interesse próprio a retornar a cargo do que foi exonerado por ser inacumulável como novo provimento.
O princípio constitucional da motivação dos atos administrativos
Authors: Osório Fábio Medina
Published: November 2017

Introdução - I. Um problema prático: os atos de promoção e remoção dos membros do Ministério Público gaúcho e a ausência de motivação do Conselho Superior da Instituição - 2. Atos de promoção ou remoção de agentes do Ministério Público e da Magistratura na carreira como atos administrativos - 3. A necessária objetividade dos critérios de merecimento na carreira do Ministério Público e da Magistratura: a motivação como instrumento de verificação dos critérios legais de mérito dos agentes públicos - 4. Discricionariedade e conceitos jurídicos indeterminados: o problema da interpretação dos critérios de merecimento - 5. Aferição de merecimento e análise dos fatos - 6. Acesso à justiça: a controlabilidade judiciária dos atos administrativos e o direito fundamental à efetiva tutela judicial - 7. Interdição à arbitrariedade dos Poderes Públicos - 8. Transferência administrativa - 9. Eficiência administrativa - 10. Moralidade administrativa - 11. Do princípio da igualdade - 12. Do provimento jurisdicional positivo ou negativo: os limites da tutela judicial - Considerações finais: da necessidade de umacultura político-administrativa democrática.
Razões de Estado - Alegação - Inconstitucionalidade
Authors: Mello Celso Antônio Bandeira de
Published: November 2017

- É preciso advertir que as razões de Estado - quando invocadas como argumento de sustentação da pretensão jurídica do Poder Público ou de qualquer outra instituição - representam expressão de um perigoso ensaio destinado a submeter, à vontade do Príncipe (o que é intolerável), a autoridade hierárquico-normativa da própria Constituição da República, comprometendo, desse modo, a idéia de que o exercício do poder estatal, quando praticado sob a égide de um regime democrático, está permanentemente exposto ao controle social dos cidadãos e à fiscalização de ordem jurídico-constitucional dos magistrados e Tribunais.
Comissão parlamentar de inquérito - Quebra de sigilo bancário - Motivação
Authors: Silveira José Neri da
Published: November 2017

- As Comissões Parlamentares de Inquérito podem decretar a quebra de sigilo bancário. sigilo fiscal e sigilo telefônico para suas investigações.- O ato com essa finalidade deve, porém. ser adequadamente motivado.- A ausência de motivação razoável permite a concessão de medida liminar em mandado de segurança.
Servidor Estadual - Adicional por tempo de serviço - Cálculo
Authors: Silveira José Néri da
Published: November 2017

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Servidor Estadual - Teto de vencimento - Paradigma
Authors: Mello Celso Antônio Bandeira de
Published: November 2017

Ação direta de inconstitucionalidade. 2. Art. 2º. da Lei Complementar nº 16, de 08/11/1996, do Estado de Pernambuco. Regime Jurídico dos servidores públicos civis do Estado. Teto de vencimentos do funcionalismo estadual correspondente ao valor da remuneração atribuída, em espécie, ao Governador do Estado. 3. Alegação de ofensa aos arts. 37, XI e 39, § 1º, da Constituição Federal. 4. A Corte firmou entendimento na ADIN 1674-5-DF, no sentido de que o teto de vencimentos, em cada Poder, deve se referir aos percebidos pelos Deputados Estaduais, Secretários de Estado e Desembargadores do Tribunal de Justiça, excluindo-se desse teto as vantagens de caráter pessoal percebidas pelos servidores, a teor dos artigos 37, XIII e 39, § 1º, da CF de 1988. 5. Relevantes os fundamentos da inicial e conveniente a suspensão cautelar da vigência do dispositivo impugnado. 6. Medida cautelar deferida para suspender, "ex nunc" e até o julgamento final da ação a eficácia do art. 2º. da Lei Complementar nº. 16/1996, do Estado de Pernambuco.
Implementação de cotas raciais em universidades e concursos públicos: problemas procedimentais e técnicas para sua superação
Authors: Vitorelli Edilson
Published: November 2017

O presente artigo analisa os problemas procedimentais decorrentes da implementação de cotas raciais em concursos públicos e para o ingresso nas universidades, sobretudo no que tange à identificação dos beneficiários da política pública e à prevenção das fraudes. Embora considere problemática a opção nacional pelas políticas de heterorreconhecimento racial, apresenta medidas para que esse procedimento, quando adotado, resguarde a segurança jurídica dos candidatos, a objetividade da avaliação e o controle público e social da seleção. A proposta é composta por três técnicas, iniciando com a criação de parâmetros de comparação racial nos editais, passando pela exigência de fundamentação adequada das decisões das comissões e concluindo com a ampliação do controle social sobre os candidatos selecionados. This paper aims to propose procedural techniques capable of implementing affirmative actions based on race, considering the specificities of race relations in Brazil. Although the country has recognized its racial inequality, it is impossible to adopt criteria based on genotype or ascendency. Moreover, the high number of interracial marriages through time originated a population with a wide variety of phenotypical profiles. It is difficult, in this context, to develop a procedure to implement affirmative action without making it useless, due to the large number of possible beneficiaries, but, on the other hand, avoiding to create a racial tribunal. This paper aims to overcome these difficulties.