bluuebunny/crossref_metadata_2025 huggingface dataset:
Adverse Psychological and Therapeutic Effects of Kratom (Mitragyna speciosa) Use: A Systematic Review
Authors: Yang Bin , Yi Shanyong , Zhang Ruiling , Abdullah Mohammad Farris Iman Leong
Published: December 2023

Aims: This review aimed to comprehensively examine kratom’s therapeutic potential for treatment of mental health-related issues as well as any related benefits and risks. Design: Systematic review. Data sources: Google Scholar, Web of Science, PubMed, Scopus, PsycINFO, EMBASE, Cochrane Library, and Medline. Review methods: Three authors carried out electronic search of articles published between 1950 to September 2022 through major databases for a duration of three months (from July to September 2022). Each author independently screened the literature for inclusion and exclusion criteria, the findings were then compared, discrepancies between authors were resolved, and the final selection of articles were reviewed. Results: A total of 46 articles were included in this review. A total of three in vitro and animal studies and five cross-sectional online surveys reported the therapeutic potential of kratom in opioid replacement therapy. In addition, a total of two animal studies and three cross-sectional online surveys highlighted the role of kratom as a potential antidepressant and anxiolytic. Contrastingly, two animal studies, 11 studies in human subjects, and 16 case reports documented the risk of kratom dependence, cravings, tolerance, and kratom-related substance use disorder as the major safety concern of implementing kratom use as a therapeutic agent. Conclusion and impact: In the absence of human clinical trial, coupled with various considerable adverse events of kratom (not limited to psychological side effects), evidence to support kratom as potential therapeutic use remains inconclusive.
Self-care among the Helping Professionals: A Systematic Literature Review
Authors: Tan Choe Chai , Sinnasamy Janaki , Zakaria Noor Syamilah
Published: December 2023

Introduction: Self-care is important in all aspect of our life. Generally, the concept of self-care is not a new term that attracted scholars to conduct relevant studies. Despite the number of self-care research on specific group or issues on the self-care practices, the comprehensive of self-care from the aspect of types, relation and factors of self-care has been relatively limited. Hence, this review synthesizes the available research exploring self-care issues among the helping professionals. Methods: A systematic review was conducted for papers published from year 2017-2021 included qualitative, quantitative, and mixed methods articles. Meanwhile, a Reporting Standards for Systematic Evidence Syntheses (ROSES) was adopted for current study. Two main journal databases, Scopus, Web of Science and additionally Google Scholar and PsycArticles were utilised. Results: The search yield 26 articles that can be analysed systematically. Outcome included identify types of self-care emphasized by helping professionals, relation, and factors influence self-care. Conclusion: Finding synthesizes the latest research on self-care, and highlights the benefits of self-care for the helping professionals. Finally, a number of recommendations were discussed at the end of the research.
Prevalence of Depression Among Community Dwelling Older Persons in Thailand and the Associated Factors: A Systematic Review
Authors: Suwanmanee Suttama , Minhat Halimatus Sakdiah
Published: December 2023

Aim: Depression symptoms in older persons are overlooked and untreated because they coincide with other conditions that older persons face. This review aimed to determine the prevalence and factors associated with depression among community dwelling older persons in Thailand according to the Social Cognitive Theory constructs. Design: Systematic review. Data sources: Four electronic databases: PubMed, PsychINFO, ScienceDirect and Scopus, with only articles published between January 2000 and December 2021 were included. Methods: The Preferred Reporting Systems for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to conduct this systematic review. All included articles were appraised using the Crowe Critical Appraisal Tool (CCAT), with all 13 studies were assessed to be of high quality, with score of more than 75. Results: A total of 13 full-texts articles were included in this review, of which 12 were cross-sectional study design, and only one was a cohort study. The prevalence of depression among older persons in Thailand were between 5.7% to 68%, with the most commonly reported factors that significantly associated with depression were gender, social support, marital status, employment status or income, and education level. Conclusion: Depression among older persons is a mental Health challenging issue in Thailand. Studying the factors that contribute to depression in older persons is more important in order to have a better understanding of the underlying causes as well as for early detection and effective management of depression among older persons in Thailand.
Application of Proteomics in Alzheimer’s Disease: A Mini Review
Authors: Sukumaran Pariveena , Bahardin Ainun Aida , Abdul Razak Luqmanul Hakim , Senik Mohd Harizal
Published: December 2023

Alzheimer’s disease (AD) is classified as one of neurodegenerative disease caused by neuronal death. It is characterized as memory impairment, including the inability to produce new memories. Since AD has low treatment effectiveness, proteomics research opens possibilities for advancement. Proteomics is the study of proteomes produced by the disease-bearing host to identify and understand diseases. In this case, to investigate the use of protein as a reliable molecular entity and their involvement in AD. Therefore, this review focused on three main applications of proteomics; the potential use of proteomics as a diagnostic tool for AD, the use of proteomics to assess the treatment progression of AD and the advancement in AD research. The review discussed three research areas utilizing the proteomics approach: ageing, behavioural, and demographic research of AD populations. Proteomic approaches have also been shown to be effective to discover the biomarkers for infectious diseases, cancers, heart diseases, and neurological disorders. Although much work remained to be done, the proteomics approach is an interesting method to be carried out in detecting AD at an earlier stage and will be very useful for AD treatment and management in the future.
Drug Repurposing of Clinically Approved Drugs to Target Epithelial-mesenchymal Transition Using Molecular Docking Approach
Authors: Chun Hao Ong , Chau Ling Tham , Harith Hanis Hazeera , Firdaus Nazmi , Israf Daud Ahmad
Published: December 2023

Introduction: Epithelial-mesenchymal transition (EMT) is a process of epithelial transformation into mesenchymal cells. It is also a process that contributes to the progression of fibrosis and cancer metastasis. Transforming growth factor-beta (TGF-β), as a potent inducer of EMT, has therefore became a potential therapeutic target. However, clinical developments of TGF-β inhibitors have been un-successful due to safety risks. Hence, drug repurposing of existing safe-to-use drugs could over-come this issue. Methods: In this study, the TGF-β receptor type 1 (ALK5) was selected as the target protein. Molecular docking was performed using known ALK5 inhibitors as positive controls. Clinical drugs with similar binding affinity and amino acid interaction were selected for in vitro experimental validation. Results: ALK5 inhibitor demonstrated binding affinities ranging from -11.2 to -9.5 kcal/mol. Analysis of amino acid interaction revealed that Val219, Ala230, Lys232, and Leu340 amino acid residues are crucial for binding. Subsequent screening of clinically approved drugs against ALK5 showed top five potential drugs (ergotamine, telmisartan, saquinavir, indinavir, and nelfinavir). The selected drugs were tested in TGF-β1-induced normal human bronchial epithelial cell line, BEAS-2B. Western blot analysis showed that the drugs did not exhibit inhibitory effects on the downregulation of epithelial proteins (E-cadherin) and upregulation of mesenchymal proteins (vimentin and α-smooth muscle actin). Conclusion: Based on these experimental outcome, it is postulated that the results from molecular docking were false positives. The tested drugs in this study could serve as negative controls in future screening against ALK5 protein.
Hepatitis C: A Review on Current and Emerging Genotyping Assays
Authors: Mohd Amin Nur Amalin Zahirah , Mat Jusoh Tuan Nur Akmalina , Irekeola Ahmad Adebayo , Shueb Rafidah Hanim
Published: December 2023

Hepatitis C is a global public health concern that infects millions of people worldwide. The continual discovery of new genotypes and subtypes of hepatitis C virus (HCV) is an indication of a persistent molecular evolution of the virus. This remains a concern in the efforts towards hepatitis C elimination, as effective management of the disease is, in part, dependent on the HCV genotype responsible for the infection. Accurate HCV screening and quantification using rapid but highly sensitive and reliable methods are crucial for the diagnosis and subsequent management of HCV-related diseases. Thus, this article discusses HCV and the common methods employed for HCV detection and genotyping. While nucleotide sequencing and phylogenetic analysis of core/E1 and NS5B region are regarded as the gold standard and the most recommended method used for HCV genotyping, electrochemical sensors are being explored for their rapidity.
Internet-Based Self-Care Monitoring Among Diabetes Mellitus Patients During The Covid-19 Pandemic: A Systematic Scoping Review
Authors: Eriyani Theresia , Mulyana Aep Maulid , Pebrianti Sandra , Shalahuddin Iwan , Fernanda Ni Putu Mulia
Published: December 2023

The COVID-19 pandemic affects blood glucose control in patients with type 2 diabetes mellitus (type 2 DM). Internet-based interventions show great potential in type 2 DM patients care. The aim of the study is to identify internet-based self-care monitoring interventions in type 2 DM patients during the COVID-19 pandemic. Using a systematic scoping review of PubMed, CINAHL, SAGE Journals, and ScienceDirect spanning 2019-2022, full-text articles, and randomized controlled trials. Study quality was assessed using the Joanna Briggs Institute (JBI) appraisal tool. Overall, 12 studies revealed that the internet was effectively used for self-care monitoring in type 2 DM patients during the COVID-19 pandemic such as to monitor blood sugar, diet, physical activity, drug use, problem solving, and dealing with stress, including mobile health (applications), web, telephone, and SMS (Short Message Service). Our finding highlights internet-based self-care monitoring can be a model of nursing intervention to prevent and increase the quality of life in DM patients.
Emerging Role of Galectins as Molecular Targets for Cancer Therapy: A Review
Authors: Shaik Mohammad Anjum , Hong- Wai Tham
Published: December 2023

In recent decades cancer incidences and mortality rates have increased. Although there is significant progress in identifying the root causes and emerging therapies, there are many molecular, cellular mechanism’s unrevealed and current treatments have yet to deliver on their promises. Common characteristics of cancer that are controlled by various mechanisms, including those involving glycosylation-dependent proliferative signalling, the ability of tumor cells and their microenvironment to sustain proliferative signalling, enhancing the replicative immortality, evading the effects of growth suppressors, resisting apoptosis, sustaining invasion and metastasis, stimulation of angiogenesis and triggering immune response are few to name. An evolutionarily conserved family of glycan-binding proteins known as galectins has a significant impact in controlling these cascades. Galectins belong to animal lectin family that function by interacting with matrix glyco-proteins on extracellular surface and also with nuclear proteins modulating the cell signalling cascades intracellularly. In this review, we analyse how galectins influence the cellular pathways that control tumor activity, providing relevant examples and highlighting their therapeutic perspective in the fight against cancer.
The Use of Fiber-Reinforced Composites for Restoration of Endodontically Treated Teeth: A Review
Authors: Dawood Alshetiwi Dawood Salman , Alawi Rabihah , Abdul Muttlib Nor Aidaniza
Published: December 2023

This review summarized the most recently published literature pertaining to the use of fiber-reinforced composite (FRC) to restore endodontically treated teeth (ETT) and its influence on the mechanical behavior of restored teeth. In-depth¬ literature review in Google Scholar, ScienceDirect and PubMed was performed for these keywords: “fiber-reinforced composite”; “fiber post”; “endodontically treated”; “short fiber-reinforced composite”— only published full-text articles between 2009 and 2021 are included in this review. Fourteen articles were selected for this review. The studies concentrated on laboratory-based research conducted on human and bovine extracted teeth with different restorative techniques. Fatigue survival and load to failure tests with assessment of survival rate and fracture strength values respectively, as well as fracture pattern analysis were done. We concluded that FRC materials have improved fracture strength of restored teeth compared to conventional composites using different restorative techniques, however not to the attained level of an intact natural tooth. In addition, authors recommend a better simulation of oral environment, such as dynamic fatigue-testing.
Cross-Sectional Study Protocol on Community Disaster Resilience in Selangor Flood-Prone Communities During Covid-19 Pandemic
Authors: Muhammad Najihah , Kadir Shahar Hayati , Abdul Manaf Rosliza
Published: December 2023

Introduction: Future floods are expected to increase in frequency and intensity. Communities must arm themselves with information and skills to overcome these disasters and limit their impact. Moreover, the Coronavirus-19 infection doubled as the transmission was thought to occur when evacuation facilities were overrun and crowded. Despite government and agency assistance, the aftermath of a flood disaster leaves victims susceptible to the impacts. Resilience is essential when battling flooding or a pandemic. Thus, this study aims to determine the community disaster resilience score and its associated factors in Selangor flood-prone communities during the COVID-19 Pandemic. Methods: A cross-sectional quantitative survey will be conducted with a sample size of 574 residents living in flood-prone areas. A validated self-administered questionnaire will be distributed in liaison with community leaders using paper and online. The questionnaire includes respondents’ demographic, flood disaster preparedness, general disaster preparedness belief, and community disaster resilience. The associations and predictors between the independent and dependent variables will be examined using bivariate analysis and multiple linear regression with a < 0.05 significance level. Discussion: Insights from this research will help communities better prepare for and recover from disasters. A more robust resilience approach requires focusing on predictors and recruiting those factors to assist health authorities in promoting flood disaster preparedness and resilience practices in the community. Researchers may comprehend the health behaviour of a community to build disaster preparedness and resilience as well as a health intervention.
Indoor Air Quality Assessment in the Office of the Transformer Manufacturing Factory in Selangor, Malaysia
Authors: Shamsudin Syazawani , Kamaludin Nurul Farahana , Sazali Nur Mariam , Awang Normah , Ithnin Anuar
Published: December 2023

Introduction: As humans spend 90% of their time inside, indoor air quality (IAQ) is critical for occupant health. The primary concern associated with low IAQ is its impact on employees’ health, comfort, and productivity. In accordance with the Industry Code of Practice on Indoor Air Quality 2010 (ICOP IAQ 2010), a ten-parameter assessment was conducted in the office of the transformer manufacturing factory in Selangor, Malaysia. Methods: The measured parameters are temperature, air movement, relative humidity, carbon dioxide (CO2), carbon monoxide (CO), formaldehyde (CH2O), particulate matter (PM10), total volatile organic compounds (TVOCs), total fungal count (TFC), and total bacterial count (TBC). This study employed both qualitative and quantitative approaches by distributing questionnaires (N = 42), and measuring the indoor air quality parameters with integrated equipment at selected stations and comparing them to the ICOP IAQ 2010 standard. Results: A majority of the measures, with the exception of air movement, CO2, and TBC, complied with the ICOP IAQ 2010 standards. The one-way ANOVA test showed that there were significant differences (p < 0.05) for the parameters of temperature, PM10, and TVOCs. The Chi-Square test revealed that sleepiness was a symptom of the sick building syndrome, affecting both male and female employees the most frequently and significantly. Conclusion: Air movement, CO2, and TBC values that did not meet ICOP IAQ 2010 requirements revealed poor IAQ at the study site, which could have a negative influence on the employees’ health. To cut down on air pollution, the improvement on the ventilation system should be done to reduce the risks to the employees’ health.
A Case of Lymphoma with Multiple Identities
Authors: Asri Alia Suzana , Yousuf Rabeya , Yahaya Azyani , Zainal Isa Izzaki , Tumian Nor Rafeah , Nasuruddin Dian Nasriana , Yusof Nurasyikin , Abdul Aziz Suria
Published: December 2023

Discordant lymphoma (DL) is the coexistence of two or more distinct subtypes in separate anatomic sites. There are limited reports on DL cases especially involving more than two subtypes in more than two sites. We report a 76-year-old man who presented with constitutional symptoms, flank mass and painless lymphadenopathies for six months. Laboratory tests revealed moderate anaemia, markedly elevated serum IgM (13400 mg/dL), IgM Lambda paraproteinemia and Lambda light chain paraproteinuria with unmeasurable serum lactate dehydrogenase due to hyperviscous sample. CT scan showed multiple subcutaneous masses over chest wall and retroperitoneum, with lytic bone lesions, and hepatosplenomegaly. Further biopsy findings with morphological, immunohistochemical and molecular analysis of the tissue sections revealed diffuse large B-Cell lymphoma in the chest wall mass, follicular lymphoma in the inguinal lymph node and lymphoplasmacytic lymphoma in the bone marrow. This case highlights the rare DL. The importance of histopathological evaluation of lymphoma despite the availability of PET-CT scans for disease staging is undeniable.
Naja species Bite Injury- Pathophysiology of Envenomation and Multidisciplinary Approach in Management
Authors: Mhd Yunin Nor Safiahani , Singh Keshvinder , Othman Mohd Noor Nashriq Umar , Govindasamy Vikneswaran , Ismail Ahmad Khaldun
Published: December 2023

Cobra bite envenomation is one of the commonest causes of snake related injuries in Malaysia. Local tissue injury following a cobra bite is a complex sequalae of envenomation that is attributed to various peptides and enzymes including cytotoxin, metalloproteases, phospholipase A2 and hyaluronidase. This case involves a young construction worker who was bitten by an unidentified snake on the dorsum of his left foot. He presented with typical features of local and systemic envenomation of a Naja species. Remote Envenomation Consultancy Services was consulted and the appropriate antivenom was administered. The patient underwent wound debridement and subsequent skin grafting. Follow up at outpatient clinic showed good skin graft uptake and recovery. Managing a significant Naja species bite envenomation can be a lengthy process requiring expertise from various subspecialties. Timely and seamless multidisciplinary approach in managing a Naja species envenomation ensures a favorable outcome with minimal complication.
Case Report: Arterial Spin Labeling Perfusion MRI Contribution for Clinical Implementation of Brain Disease
Authors: Amnesti Merry , R Celine Catharina , F Eunike Serfina , S Revina Dewi , Wangsadjadja Charles
Published: December 2023

Currently, ASL is widely used as an additional breakthrough sequence in MRI due to acquiring reliable results. The case report aims to prove the efficacy and effectiveness of a quantitative method of ASL sequence through the calculation of the cerebral blood flow (CBF) on CBF maps in different cases. ASL sequence has been done on four patients with different cases. Then, the authors put 2 regions of interest (ROI) for measurement in normal and different regions on CBF maps and then calculated the average value result from CBF maps. ASL has been proven as a reliable and breakthrough sequence in MRI for detecting brain disease with a non-invasive method through the calculation of CBF value. ASL should be used as an additional protocol in brain examinations because it allows radiologists to assess the significance of CBF values using a quantitative method that is more reliable and non-invasive.
Ethical Concerns in Accessing Healthcare Information from Social Media by Patients with Terminal Diseases in Kenya: Opportunities and Challenges
Authors: Nason Benson Vundi
Published: December 2023

Purpose: This paper investigated the ethical concerns in in accessing healthcare information from social media by patients with terminal diseases, opportunities and challenges: Kenyan experience.

Methodology: It had 3 objectives to: a) determine ethical concerns in accessing healthcare information from social media; b) evaluate the opportunities patients with terminal diseases have in accessing healthcare information from the social media; c) investigate the challenges patients with terminal diseases have when accessing healthcare information from the social media. The study was desk review; that involved identifying and scanning relevant literature, analysis of the secondary data; creation a reference list and organization of the documents.

Findings: The study findings were: all the articles 100% confirmed core ethical issues in accessing healthcare information: patients’ anonymity, confidentiality, privacy, physicians’ professionalism, and data protection; 98% agreed on imperative response by physicians to patient concerns. Social media presents opportunities to patients: 51% access, and shared (50%) healthcare information; 44% made decisions; 46% were empowered and their capacity build; 51% accessed experts advise; 48% joined social support-groups. There were challenges in accessing healthcare information: 50% accessing misinformation; 36% technological illiteracy, 48% personal data security.

Unique Contribution to Theory Policy and Practice: The study concluded that social media presents enables accessing and sharing of healthcare information. However, for effectiveness ethical concerns like: patients’ confidentiality and privacy, physicians’ professionalism, and protection of patients’ data. Stakeholders need to work together to eliminate the ethical issues and challenges faced by patients using social media as a source of healthcare information.
Review on Nutrition and Dietetics
Authors: Rashmi Sonkusare  , Rahil Parvez Shaikh  , Toufik Mulani  , Aasim Shaikh  , Taskin Khan
Published: December 2023

Diet and nutrition play an important and fundamental role in the lives of everyone. It contributes to the formation of a healthy body and a strong mind. We know that nutrients-rich foods can remove toxins from the body, promote a good immune system, reduce hunger, and prevent obesity. Obesity is one of the most worrying, alarming and fastest-growing pandemics. It affects not only adults, but also adolescents and children. Early onset of diseases requires quick attention to control the physical, psychological, financial and social burdens it generates. Children with autism and autism spectrum disorders (ASDs) are often affected by eating disorders. Their preference for low-nutrient, energy-intensive foods may alter metabolism, lead to accumulation of oxidative atoms, and deteriorate their mental and physical condition. Although diet and weight loss are now common among the general population, it is difficult to raise awareness of nutrition, nutrition and obesity in children with special needs. Despite efforts, parents of children with such children cannot usually control their diet, as tantrums and behavioural problems are common. Currently, doctors and parents must work with nutritionists and nutritionists to help these children eat healthy, stay fit and improve their quality of life
Structural Study of the Short Story Title Eyang by Putu Wijaya
Authors: Safinatul Hasanah Harahap Nailah Faizah S Rambe, Putri Alicya Zafira,
Published: December 2023

This article aims to determine the structural structure of the short story Eyang Karya Putu Wijaya. The approach used is qualitative by reading and observing Eyang's short stories. The results of the research provide an illustration that the short story Eyang was formed coherently by Putu Wijaya, so that it has coherence and relationships between elements and other elements. The theme raised is about life, this theme is supported by the setting which tells the place and time of events from grandparent's arrival until grandpa hands over the savings he has saved for 20 years. in the future, so that it supports the theme elements and other elements. Apart from the elements of theme, setting and plot, there is another element, namely point of view. The point of view in the lawsuit short story is first person point of view where I am the main character. Apart from having a connection between elements, the short story Eyang also presents the moral values ??that Putu Wijaya wants to convey to readers. The moral message conveyed by Putu Wijaya in the short story Eyang is, to be honest in doing things, not to insult other people, and to be trustworthy in your work. The moral messages conveyed often produce different interpretations from each reader, but Putu Wijaya in writing his short stories is able to make readers appreciate the meaning.
Case Series to Evaluate the Efficacy of Selected Treatment Modality in the Management of Vātarakta (Gouty Arthritis)
Authors: Sewwandi Samaranayaka Liyanage Gayani , Hazari Fathima Shazmin , Sandunika Mallawa Arachchige Maheshi
Published: December 2023

Vātarakta is a more common and distressing metabolic condition that exists nowadays. Rakta (blood) is the major Dūshya (vitiated) in Vātapradhāna (predominance of Vāta), Tridōshaja (three body humors), and Vātavyādhi (disease of Vāta). Vātarakta is a condition in which Vāta, a prominent Dōsha, is unduly worsened by vitiated Rakta. Gout and Vātarakta are associated in modern science. Gout is a purine metabolic disorder that results in hyperuricemia and the development of monosodium urate crystals in joints. Gout’s primary symptom is pain, which interferes with sufferers’ daily lives. The purpose of this study is to determine the efficacy of a selected treatment modality in the management of Vātarakta. Three case presentations with a follow-up period of one month were studied. Treatment modality including Sinhasya Panchamūli Phānta, Chadraprabhā Vati, Nawarathna Kalka, Thriphalā Chūrna, Pinda Thaila, and Nadi Swēda was advised for four months along with Pathya Apathya (wholesome and unwholesome). Pre- and post-treatment assessments of subjective criteria were made. According to the results, the symptoms were reduced by 25%, 33.33%, 50%, 66.66%, and 100%. It may be concluded that Pathya Apathya, combined with a selected treatment modality, is a secure and reliable treatment for Vātarakta.
Transanal minimally invasive surgery for benign and malignant rectal lesions: midterm outcomes from a tertiary center
Authors: Al-Dhaheri Mahmood , Al-Ishaq Fajer , Toffaha Ali , Nada Mohamed Abu , Parvaiz Amjad , Kurer Mohamed
Published: December 2023

BACKGROUND:

Although transanal minimally invasive surgery (TAMIS) for rectal neoplasia has gained wide acceptance, the mid-term and long-term outcomes are not widely reported in the literature.

OBJECTIVE:

Describe the mid-term outcomes of patients who underwent TAMIS for benign and malignant rectal lesions in a single center.

DESIGN:

Retrospective cohort study

SETTINGS:

Tertiary referral center

PATIENTS AND METHODS:

Demographic, clinical, and oncological outcomes of patients who underwent TAMIS between January 2015 and December 2022 were prospectively collected. The indication for TAMIS was based on the National Comprehensive Cancer Network guidelines. The follow up for the cancer patients included clinical examination, tumor markers every 6 months and MRI rectum at the end of one year. In addition, colonoscopy and CT scan at years one and three and a final CT scan and colonoscopy at year five.

MAIN OUTCOME MEASURES:

Mid-term oncological and clinical outcome.

RESULTS:

Thirty elective TAMIS procedures included adenocarcinoma for 33.3% (n=10) of the patients, 20% (n=6) neuroendocrine tumor and the 40% (n=12) were adenomatous lesions. Negative resection margins were achieved in all malignant lesions. Perioperative complications occurred in 2 patients (6.6%), one patient had breaching into the peritoneal cavity, and postoperative hypotension occurred in another patient. The median follow-up time was 23 months (range: 5–72 months). Two patients with adenoma and positive margins developed recurrent adenoma (6.6%) and one patient with initial polypectomy biopsy of adenocarcinoma, had TAMIS with histopathology of adenoma and distant metastasis had developed.

CONCLUSIONS:

TAMIS for local excision of rectal neoplasia is a valid option with favorable mid-term outcomes provided there is adherence to careful selection criteria.

LIMITATIONS:

Retrospective nature and small number of the patients.
Brucellosis in Omani children: a multicenter experience over 15 years
Authors: Sawafi Lamees Al , Tai Amal Al , Reesi Mohammed Al , Subhi Mahmood Al , Busaidi Muna Al , Abri Sanaa Al , Waili Badria Al
Published: December 2023

BACKGROUND:

Brucellosis, a common zoonotic disease worldwide, can lead to serious complications in humans. In Oman, the disease occurs most often in the south, but is increasing in the north.

OBJECTIVES:

Describe brucellosis in children in the Northern Governorate in Oman.

DESIGN:

Retrospective, observational

SETTINGS:

Hospitals in the Northern Governorate in Oman.

PATIENTS AND METHODS:

We collected data on the demographics, distribution, common clinical presentations, risk factors, laboratory findings, therapy, and complications of confirmed cases of brucellosis. We included all brucellosis cases up to the age of 13 years at the Child Health Department in Royal, Suhar, Al Rustaq and Nizwa Hospitals over a 15-year period.

MAIN OUTCOME MEASURES:

Descriptive findings of brucellosis

SAMPLE SIZE:

57 confirmed cases

RESULTS:

The 57 confirmed cases of Brucella had a mean age of 6 years. Most of the cases were from Dhakhiliya 21 (36.8%) and Batinah 18 (31.6%). Consumption of raw milk was documented in 75% and 41% had animal contact. From 2010, there was a marked rise of the cases with a maximum rise was noticed in 2019 with a total of 10 cases. The main clinical manifestations were fever (92%, n=52), arthritis (44%, n=25), which involved mainly knees and hips. Forty-two had bacteremia, 41% anemia, 10% osteomyelitis/septic arthritis, one case with congenital brucellosis and one case neurobrucellosis (1.8%). Forty cases had positive serology results of which 19 had positive cultures. Most cases had received cotrimoxazole and rifampin as the primary treatment regimen 22 (40%). Four patients relapsed (7%) after treatment completion.

CONCLUSION:

This study showed the distribution and clinical characteristics of brucellosis in different regions in the Northern Governorate in Oman. Although the numbers of cases remained low, the gradual increase is concerning for public health and preventive strategies. Further studies are needed to compare this data with the Southern region.

LIMITATION:

Retrospective study with small sample size.
Study of Fixed Points and Chaos in Wave Propagation for the Generalized Damped Forced Korteweg-de Vries Equation using Bifurcation Analysis
Authors: TOMAR Shruti , CHADHA Naresh M.
Published: December 2023

In this article, we consider the Generalized Damped Forced Korteweg-de Vries (GDFKdV) equation. The forcing term considered is of the form $F(U)=U(U-v_1)(U-v_2)$, where $v_1$ and $v_2$ are free parameters. We investigate the behaviour of fixed points evaluated for the corresponding dynamical system of our model problem. With respect to these fixed points, we investigate the effects of a few significant parameters involved in the model, namely, the free parameters $v_1$ and $v_2$, the nonlinear, dispersion and damping coefficients using the tools from bifurcation analysis. We also obtain the wave plots for the critical values of the nonlinear and dispersion coefficients for which the system becomes unstable and exhibit chaotic behaviour. We confirm the chaos in our dynamical system under various conditions with the help of Lyapunov exponents.
Challenges in optimizing 3D scaffold for dentin-pulp complex regeneration
Authors: ZAHEDAH Rola , DİNÇ Bircan
Published: December 2023

Regenerating dentin-pulp complex (DPC) using tissue engineering offers a novel and promising therapeutic alternative for restoring teeth. A crucial component of such a therapy is the designing and fabrication of an appropriate 3D Scaffold. In this review, we set out to highlight some of the general challenges associated with optimizing the most suitable scaffold for DPC regeneration to develop "bio-mimetic" approaches that influence stem cell proliferation, differentiation, and angiogenesis. It is essential to comprehend the biology and physical features of the dentin-pulp complex with updated bionanotechnology to overcome the limitations of biomaterials to address the challenges in manufacturing the optimal scaffold. To date, current scaffolding models fail to regenerate a whole tooth. The success of regenerative dentistry relies on stem cells and scaffolds may shape the future of dental treatment.
Modern Dönem Çeviri Faaliyetlerinin Arap Edebiyatının Gelişimine Katkısı
Authors: ÖZEL Harun , SOUMANA Youssoufa
Published: December 2023

Arap dünyasında çeviri hareketleri ilk olarak Emevîler döneminin sonlarında ve Abbâsîler döneminin başlarında gelişmeye başlamıştır. Bu faaliyetlerin özellikle Halife el-Me’mun (ö. 218/833) döneminde büyük bir gelişme göstererek kurumsal bir boyut kazanması, o dönemde Arap dilinin gelişmesini sağlayan en önemli faktörlerden biri olmuştur. Benzer şekilde 19. yüzyılın başlarında Mehmet Ali Paşa (ö. 1849) döneminde askerî ve teknik alanlarda başlatılan tercüme faaliyetleri, zamanla tarih, coğrafya, felsefe gibi hemen her alanda kendisini göstermiş; 1870’lerden sonra özellikle edebî eserlerin tercümesinde büyük bir artış olmuştur. Arap dünyasının kültürel ve fikri bağlamda modern Batı uygarlığı ile iletişim kurmasını sağlayan bu tercüme faaliyetleri, Mısırlı okuyucuları yalnızca Avrupa yazım teknikleri, yeni yazım türleri ve üslupları ile tanıştırmakla kalmamış; Abbâsîler döneminde altın çağına ulaştıktan sonra gerileme dönemine giren Arap edebiyatının yeniden şahlanmasında aktif rol oynayan en önemli etkenlerden biri olmuştur. Bu etkilenmeyle beraber duyguları ifade aracı olan şiir ve nesir geleneksel kalıplarından çıkarılarak çağın insanının duygularını aktarabileceği modern kalıplara dökülmeye başlanmış; tiyatro, roman ve makale gibi yeni türler ortaya çıkmıştır. Bu çalışmada, 19. yüzyılda Osmanlı coğrafyasının önemli merkezlerinden biri olan Mısır’da başlayan çeviri faaliyetlerinin Arap edebiyatının gelişimine katkıları ele alınmıştır.
UPAYA PENINGKATAN HASIL BELAJAR EKONOMI MELALUI APLIKASI GOOGLE CLASSROOM BAGI SISWA KELAS X IPA 5 SMAN 1 DEPOK
Authors: SYAHRUDIN TEGUH
Published: December 2023

This research aims to improve economic learning outcomes through the Google Classroom application for class X Science 5 students at SMAN 1 Depok. This research is classroom action research. The subjects in this research were students of Class The data collection technique in this research is using learning outcomes tests, observation results, and documentation. Researchers used pre-tests and post-tests to determine improvements in student learning outcomes. The test used in this research is in the form of an essay. This research uses qualitative data. Based on the research results, it can be concluded that there is a positive influence on online learning, namely by using the Google Classroom application. So it can have an effect on improving student learning outcomes. So the conclusion is drawn that the use of media using the Google Classroom application can improve the learning outcomes of class X Science 5 students at SMA Negeri 1 Depok.

ABSTRAKPenelitian ini bertujuan untuk meningkatkan hasil belajar ekonomi melalui aplikasi google classroom bagi siswa kelas X IPA 5 SMAN 1 Depok. Penelitian ini merupakan penelitian tindakan kelas. Subjek dalam penelitian ini adalah siswa Kelas X IPA 5 SMAN 1 Depok tahun pelajaran 2019/2020 dengan jumlah 36 siswa. Teknik pengumpulan data padapenelitian ini adalah menggunakan tes hasil belajar, hasil observasi, dan dokumentasi. Peneliti menggunakan pre test dan post test untuk mengetahui peningkatan hasil belajar siswa. Tes yang digunakan dalam penelitian ini berbentuk esay. Penelitian ini menggunakan data kualitatif. Berdasarkan hasil penelitian maka dapat disimpulkan bahwa ada pengaruh positif pembelajaran daring yaitu dengan penggunaan aplikasi google classroom. Sehingga dapat berpengaruh terhadap peningkatan hasil belajar siswa. Maka ditarik kesimpulan bahwa penggunaan media dengan menggunakan aplikasi Google Classroom dapat meningkatkan hasil belajar siswa kelas X IPA 5 SMA Negeri 1 Depok.
ANEURISMA DA AORTA ABDOMINAL INFRARRENAL COM SINAIS DE INSTABILIDADE NA ANGIOTOMOGRAFIA TAMPONADO POR HEMATOMA RETROPERITONEAL: RELATO DE CASO
Authors: Bonfim Mariana Eugênia Zacharias , Scudeler Letícia Kremer , Freitas Vanessa Kamizake de
Published: December 2023

Aneurisma é uma dilatação pontual e irreversível da parede arterial, sendo que o aneurisma de aorta abdominal (AAA) é o subtipo mais comum. Dessa forma, esse artigo teve por objetivo relatar um caso de aneurisma de aorta abdominal infrarrenal com sinais de ruptura iminente na angiotomografia, em um paciente idoso e tabagista, com quadro clínico de início há 48 horas, no qual o paciente ainda encontrava-se hemodinamicamente estável devido ao tamponamento do local de ruptura por um hematoma retroperitoneal visto na cirurgia. Considerando a temática proposta, foram descritos, além da abordagem inicial, os exames e procedimentos realizados e a evolução do paciente durante a internação, com discussão e revisão bibliográfica sobre o tema.
ACIDENTE VASCULAR CEREBRAL ISQUÊMICO SECUNDÁRIO À TROMBOCITEMIA ESSENCIAL: UM RELATO DE CASO
Authors: Bonfim Mariana Eugênia Zacharias , Scudeler Letícia Kremer , Freitas Vanessa Kamizake de
Published: December 2023

A trombocitemia essencial (TE) é uma neoplasia mieloproliferativa caracterizada por trombocitose periférica devido à hiperplasia megacariocítica.  É uma doença rara, com incidência de 1 a 2 casos/100.000 habitantes/ano. As manifestações clínicas dominantes são trombóticas e/ou hemorrágicas. Porém, cerca de 25% a 35% dos pacientes são assintomáticos. Mas apesar de silenciosa, complicações trombóticas podem ocorrer em 10 a 20% dos pacientes. Angina, infarto do miocárdio, acidente vascular cerebral (AVC) e embolia pulmonar podem representar a primeira manifestação da doença. Apesar disso, poucos casos associando eventos trombóticos com a TE tem sido descritos na literatura. Deste modo, foi relatado um caso de AVC isquêmico secundário à TE em uma paciente de 85 anos, diagnosticada com a neoplasia mieloproliferativa há 8 anos, em uso de hidroxiureia 2 vezes por semana pelo mesmo período, porém com abandono de acompanhamento hematológico há 2 anos.
Why Are There So Many Digital Identities?
Authors: Landrigan Mitchell , Wilson Stephen , Fraser Hamish
Published: December 2023

This article analyses why people have so many digital identities and offers suggestions to reduce the numbers to more reasonable levels.  Digital identity thinking has been dominated by the objective of general-purpose reusable identity as a response to the unwieldy profusion of identifiers that came with expanding ecommerce. The notion of reusable digital identity is somewhat intuitive, energised by the mental model of humans exercising a virtual self in cyberspace. Many user interfaces are constructed to exhibit an intentional stance suggestive of humans having a digital counterpart making our digital actions more lifelike and comprehensible.

In some nations, there is a precedent for national identity, which makes general-purpose digital identity culturally more logical, even appealing. In common law countries, however, the market for reusable digital identity is still not mature. To date, there is no solid business case for general purpose reusable identity - largely because it proves costlier than expected to reengineer transactional identifiers to align (or federate) with an intuitive singular digital identity. Thus, individuals must manage many siloed, special purpose identifiers, account names, passwords, and piecemeal authenticators.

If transactional identifiers go hand in hand with transaction systems, then there will likely remain a need for about as many identifiers as there are transactional services. Recent technology developments, especially in cryptographic verifiable credentials and mobile digital wallets, may provide ways to automate the management of multiple identifiers and achieve the desired usability anticipated from singular identity without disrupting the forces that have led to transaction specific identification.
I Need You To Survive: Black Women Resisting White Supremacy Culture for Faculty and Student Wellbeing
Authors: Myers Marrielle , Id-Deen Lateefah
Published: December 2023

The K-12 teaching population in the United States remains overwhelmingly White despite rapid changes in racial demographics. Black prospective educators enrolled in teacher preparation programs often find themselves isolated and subjected to racism.  Racial affinity groups have been established to support students of Color. Faculty mentors of these groups spend substantial time, physical, and emotional energy supporting students who navigate the violence of higher education institutions. Given recent and ongoing pandemics, supporting students to survive, thrive, and develop psychological literacy is critical work and has become more time intensive. This article examines the experiences of two Black women faculty mentors working with Black undergraduate students. Findings indicate that notwithstanding the labor, mentoring has supported faculty members’ wellbeing, thereby disrupting traditional notions of service leading to burnout. The authors posit that affinity mentoring is mutually beneficial for faculty and student wellbeing. Implications and transferability are discussed.
Living at Work: Teaching Online During the COVID-19 Pandemic
Authors: Hulbert Rachelle , Maslin Peter , Baker Sue
Published: December 2023

This article presents a case study of what educators from an initial teacher education provider in Aotearoa, New Zealand learnt from the collapse of institutional practice architecture during the COVID-19 lockdown in March 2020. It explores how educators responded to the challenges emerging from living at work and recognises the interconnected links of educators’ practices in their sayings, doings, and relatings. The study was conducted using semi-structured interviews to gather in the moment lived experiences of nine teacher educators in their ‘living at work’ context. The insight from these interviews provides a unique perspective of how educator and student wellbeing can be sustained through relationships. The collapse of institutional practice architecture highlighted arrangements and set-ups within the institute that enabled or constrained educator practices and how the changing arrangements impacted student wellbeing.
Allegations, Abuse and Discrimination: Using Student Evaluation of Teaching Surveys to Support Student and Educator Wellbeing
Authors: Cunningham Samuel , Cathcart Abby , Graham Tina
Published: December 2023

Student Evaluation of Teaching surveys (SETs) are used at universities to inform teaching practice and subject design. However, there is increasing concern about the impact of allegations, abuse, and discrimination in survey open text components. Here we discuss the implementation of an automated screening mechanism using a combination of dictionary and machine learning approaches. We present both a process diagram detailing how the screening is performed, as well as a form of categorisation for comments that are unacceptable or indicate a potential risk of harm. Examples of real comments in each of these categories are presented to demonstrate the depth of the challenge and potential cause for concern. Ultimately, we argue that student and educator wellbeing are inextricably connected and exposing staff to abusive and discriminatory comments causes harm. Furthermore, SETs are an important channel for students to raise concerns about their own wellbeing and potentially unsafe experiences in the learning environment.
Peer-supported Teaching Practice: Embodying a Relational, Practice-Led Approach to Enhancing Educator Wellbeing and Practice
Authors: Hansen Lauren , Chambers Tim , Hamilton Danielle
Published: December 2023

Peer review of teaching (PRT) programs have the capacity to address the practice imperative of evaluating and enhancing teaching practice, and the ethical imperative of safeguarding and promoting educator wellbeing, which is intrinsically linked to student wellbeing. This article outlines the practice-led development of an institution-wide, embedded and contextualised PRT program, which we conceptualise as Peer-supported Teaching Practice (PTP). In contrast to traditional PRT, our working framework is built from the ground up and situates the educator as the driver of a relational peer-review process informed by psychological wellbeing literature. By incorporating peer reflection as a core function of the model, we seek to ensure all staff can access growth-fostering peer relationships regardless of their role, discipline or existing social capital. Rather than position academic developers as the facilitators of these conversations, we argue that peers are best equipped to support each other to explore, interrogate and mutually develop the embodied 'self-in-practice'.
Delivering Quality WIL Without Compromising Wellbeing: Exploring Staff and Student Wellbeing in a WIL Context Through the Lens of Organisational Health
Authors: Grant-Smith Deanna , Feldman Alicia
Published: December 2023

Recent scholarship has highlighted the need to be attentive to the student experience of placement-based work-integrated learning and its possible impacts on the wellbeing of student participants. The experiences of staff involved in planning, delivering and supporting work-integrated learning programs and the impact on their wellbeing have received less attention. Using data from a survey conducted at an elite Australian university, this article explores staff perspectives on, and experiences of, work-integrated learning. Through the theoretical lens of organisational health, this article proposes key contributors to ensuring quality learning outcomes for students without comprising the wellbeing of staff. These include conducting realistic workload assessments and providing staffing and allocating workload in line with these; providing appropriate training, staff recognition and reward, and employment which recognises work-integrated learning as a specialist skillset; and resourcing skilled administrative support and technological systems.