bluuebunny/crossref_metadata_2025 huggingface dataset:
The Protective Effects of α-Mangostin Attenuate Sodium Iodate-Induced Cytotoxicity and Oxidative Injury via Mediating SIRT-3 Inactivation via the PI3K/AKT/PGC-1α Pathway
Authors: Chuang Chen-Ju , Wang Meilin , Yeh Jui-Hsuan , Chen Tzu-Chun , Tsou Shang-Chun , Lee Yi-Ju , Chang Yuan-Yen , Lin Hui-Wen
Published: November 2021

It is well known that age-related macular degeneration (AMD) is an irreversible neurodegenerative disease that can cause blindness in the elderly. Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is a part of the pathogenesis of AMD. In this study, we evaluated the protective effect and mechanisms of alpha-mangostin (α-mangostin, α-MG) against NaIO3-induced reactive oxygen species (ROS)-dependent toxicity, which activates apoptosis in vivo and in vitro. MTT assay and flow cytometry demonstrated that the pretreatment of ARPE-19 cells with α-MG (0, 3.75, 7.5, and 15 μM) significantly increased cell viability and reduced apoptosis from NaIO3-induced oxidative stress in a concentration-dependent manner, which was achieved by the inhibition of Bax, cleaved PARP-1, cleaved caspase-3 protein expression, and enhancement of Bcl-2 protein. Furthermore, pre-incubation of ARPE-19 cells with α-MG markedly inhibited the intracellular ROS and extracellular H2O2 generation via blocking of the abnormal enzyme activities of superoxide dismutase (SOD), the downregulated levels of catalase (CAT), and the endogenous antioxidant, glutathione (GSH), which were regulated by decreasing PI3K-AKT-PGC-1α-STRT-3 signaling in ARPE-19 cells. In addition, our in vivo results indicated that α-MG improved retinal deformation and increased the thickness of both the outer nuclear layer and inner nuclear layer by inhibiting the expression of cleaved caspase-3 protein. Taken together, our results suggest that α-MG effectively protects human ARPE-19 cells from NaIO3-induced oxidative damage via antiapoptotic and antioxidant effects.
Recent Advances in Understanding the Function of the PGIP Gene and the Research of Its Proteins for the Disease Resistance of Plants
Authors: Cheng Siqi , Li Ruonan , Lin Lili , Shi Haojie , Liu Xunyan , Yu Chao
Published: November 2021

Polygalacturonase-inhibiting protein (PGIP) is an important plant biochemical anti-disease factor. PGIP has a leucine-rich repeat structure that can selectively bind and inhibit the activity of endo-polygalacturonase (endo-PG) in fungi, playing a key role in plant disease resistance. The regulation of PGIP in plant disease resistance has been well studied, and the effect of PGIP to increase disease resistance is clear. This review summarizes recent advances in understanding the PGIP protein structure, the PGIP mechanism of plant disease resistance, and anti-disease activity by PGIP gene transfer. This overview should contribute to a better understanding of PGIP function and can help guide resistance breeding of PGIP for anti-disease effects.
RETRACTED: Zhao, S.; Lee, S. Biomaterial-Modified Magnetic Nanoparticles γ-Fe2O3, Fe3O4 Used to Improve the Efficiency of Hyperthermia of Tumors in HepG2 Model. Appl. Sci. 2021, 11, 2017
Authors: Zhao Shang , Lee Seoksoon
Published: November 2021

The authors and journal retract the article, “Biomaterial-Modified Magnetic Nanoparticles γ-Fe2O3, Fe3O4 Used to Improve the Efficiency of Hyperthermia of Tumors in HepG2 Model” [...]
How the Implementation of BREEAM in Hotels Could Help to Achieve the SDGs
Authors: Serrano-Baena Maria M. , Hidalgo Fernández Rafael E. , Carranza-Cañadas Pilar , Triviño-Tarradas Paula
Published: November 2021

The 2030 Agenda for Sustainable Development and its 17 Sustainable Development Goals (SDGs) was approved in 2015 by the United Nations. It is a call of action to protect our planet, end poverty and improve the lives and prospects of all. Sustainable development has been fundamental in the tourism and construction sectors in the past few decades. Nowadays, developing countries are leaders in green engineering procedures, and progressively, hotels are including sustainable standards in their designs, architecture and management. In places where tourism is the main contributor to the Gross Domestic Product, the incorporation of energy certifications is crucial. In this context, this article explores the positive implications of the application of the Building Research Establishment Environmental Assessment Method (BREEAM) on hotels in relation to the achievement of SDGs. The study analyses the influence of BREEAM on hotel design using six case studies and examines the sustainable modifications incorporated. Qualitative data were obtained through in-depth interviews and by the analysis of the documentation provided. The results revealed that a BREEAM approach in the initial stage of a project will optimize the sustainability of the hotel and can help with the achievement of several of the SDGs.
How Does the Spatial Structure of High-Speed Rail Station Areas Evolve? A Case Study of Zhengzhou East Railway Station, China
Authors: Wang Xiaomin , Liu Jingyu , Zhang Wenxin
Published: November 2021

The rapid development of high-speed rail (HSR) and station areas has shortened the spatial and temporal distances among cities, improved the accessibility of cities, and affected the spatial agglomeration and diffusion of populations and of social and economic activities. This has led to spatial reconfiguration of production factors within cities, which has the potential to drive the reconstruction of urban spatial structures. Based on POI and land-use data, this paper defines the spatial scope of the HSR station area and explores the characteristics and influencing factors of its spatial structure from the perspective of industry. The study area i is set at 2000 m. Since the opening of the HSR, the industrial distribution has exhibited a significant circular, multi-core, and axial belt spatial structure. The spatial structure of each sub-industry is different. On the whole, internal and external transport and agglomeration economies have significant impacts on the industrial spatial distribution, and land rent has gradually decreased in importance with the development of HSR station areas. The intensity of the effects of different factors varies among different industries. The mechanisms by which the spatial structure of the station area is formed are discussed and include location accessibility, micro-market factors, node station attributes, the availability of a sufficient amount of undeveloped land, the characteristics and needs of HSR passengers, and policies and systems.
Design and 3D Printing of Interbody Fusion Cage Based on TPMS Porous Structure
Authors: Qi Jinlai , Gong Youping , Chen Honghao , He Junling , Qiao Zizhou , Chen Yi , Shao Huifeng , Li Wenxin , Chen Guojin , Wang Maofa , Zhou Chuanping , Zhang Xiang
Published: November 2021

To solve the mismatch between the comprehensive mechanical properties of the spinal fusion cage and body, a fusion cage inner hole design method based on controllable TPMS-P to characterize the inner hole structure is proposed to solve the related problems. Firstly, the method of TPMS-P parameterization was used to construct the bionic porous structure model, which was designed as the linear gradual internal porous structure model. Then, we optimized the topology of the obtained porous structure implants to achieve precise control of the overall comprehensive mechanical properties of the fusion cage structure and obtain an optimized model that matched the mechanical properties of the fusion cage. To verify whether the method met the requirements, its simulation model was established. The porous structure was fabricated by selective laser processing, and its properties were tested and analyzed. The results show that its yield strength is 79.83 MPa, which match well with spinal bone tissue.
A Novel Embedded Feature Selection and Dimensionality Reduction Method for an SVM Type Classifier to Predict Periventricular Leukomalacia (PVL) in Neonates
Authors: Bender Dieter , Licht Daniel J. , Nataraj C.
Published: November 2021

This paper is concerned with the prediction of the occurrence of periventricular leukomalacia (PVL) in neonates after heart surgery. Our prior work shows that the Support Vector Machine (SVM) classifier can be a powerful tool in predicting clinical outcomes of such complicated and uncommon diseases, even when the number of data samples is low. In the presented work, we first illustrate and discuss the shortcomings of the traditional automatic machine learning (aML) approach. Consequently, we describe our methodology for addressing these shortcomings, while utilizing the designed interactive ML (iML) algorithm. Finally, we conclude with a discussion of the developed method and the results obtained. In sum, by adding an additional (Genetic Algorithm) optimization step in the SVM learning framework, we were able to (a) reduce the dimensionality of an SVM model from 248 to 53 features, (b) increase generalization that was confirmed by a 100% accuracy assessed on an unseen testing set, and (c) improve the overall SVM model’s performance from 65% to 100% testing accuracy, utilizing the proposed iML method.
Geochemistry of the Dust Collected by Passive Samplers as a Tool for Search of Pollution Sources: The Case of Klaipėda Port, Lithuania
Authors: Rapalis Paulius , Zinkutė Rimantė , Lazareva Nadežda , Suzdalev Sergej , Taraškevičius Ričardas
Published: November 2021

Geochemical investigations of total suspended particulates (TSP) help detect hotspots and emission sources in port cities with stevedoring operations. The aim was to reveal these sources via geochemical indices (gI). TSP were collected in Klaipėda using original passive samplers in ten sites during four periods, during one of them, in ten additional sites near iron ore stevedoring (IOS). The contents of 22 elements (PHEs, crustal, Br, Cl) were determined by EDXRF in TSP and characteristic dust (CD) of stevedored iron ore, apatite, phosphorite, potassium fertilizers, and in waste incineration ash. Median Fe content in TSP near IOS was ~29%. The significant anthropogenic origin of clusters Fe–Cr, Sr–P, V–Ni–Zn–Cu, Pb–As, and Mg–Ca, Br–S–Cl was confirmed by gI mapping and analysis of CD. Significant temporal variability of Cl, S, Sr, Ni, Br, V, and Zn due to weather changes was revealed. Near IOS, significantly higher values of gI were found for Fe and Cr, while far from IOS, for K, Sr, Ti, Rb, Cu, Al, Si, Zr, Ca, Mg. Significantly higher values of normalized enrichment factor near IOS were not only for Fe and Cr, but also for As, Pb, S, Mn, Br, and Cl.
Compressive Properties of Green Velvet Material Used in Mattress Bedding
Authors: Liu Qingqing , Gu Yanting , Xu Wei , Lu Tao , Li Wenjun , Fan Haibin
Published: November 2021

With the increasing awareness of environmental protection, Green Velvet Material (PLON), a renewable and environmentally friendly material, has been widely applied to mattresses. In order to improve the compressive properties of PLON, a series of experiments were carried out with special attention given to the compression deformation characteristics, support performance of the PLON blocks and its effective application in mattress products. The results are: (1) Average slopes of the load-deformation curves’ two phases are represented by K1 and K2, respectively. K1 is more sensitive to density changes that range from 30 kg/m3 to 50 kg/m3, while K2 is sensitive to density changes that range from 20 kg/m3 to 50 kg/m3. Their values increase with the rise of density; (2) 25% IFD, 40% IFD, 65% IFD, SF and IHF values are sensitive to density changes and they significantly increase with the rise of density. PLON blocks have excellent supporting properties and are considered to be comfortable according to American FPF Test Standard (ASTM-D3574-B1) when used in mattress bedding; (3) a PLON block density of 30 kg/m3 is preferentially selected for the softer type of mattress, while a PLON block density of 40 kg/m3 is preferentially selected for the harder type of mattress. The compression deformation characteristics and support performance of the PLON blocks were analyzed and the effective application of PLON in mattress products was explored through the above research.
Antimalarial Drug Predictions Using Molecular Descriptors and Machine Learning against Plasmodium Falciparum
Authors: Mswahili Medard Edmund , Martin Gati Lother , Woo Jiyoung , Choi Guang J. , Jeong Young-Seob
Published: November 2021

Malaria remains by far one of the most threatening and dangerous illnesses caused by the plasmodium falciparum parasite. Chloroquine (CQ) and first-line artemisinin-based combination treatment (ACT) have long been the drug of choice for the treatment and controlling of malaria; however, the emergence of CQ-resistant and artemisinin resistance parasites is now present in most areas where malaria is endemic. In this work, we developed five machine learning models to predict antimalarial bioactivities of a drug against plasmodium falciparum from the features (i.e., molecular descriptors values) obtained from PaDEL software from SMILES of compounds and compare the machine learning models by experiments with our collected data of 4794 instances. As a consequence, we found that three models amongst the five, namely artificial neural network (ANN), extreme gradient boost (XGB), and random forest (RF), outperform the others in terms of accuracy while observing that, using roughly a quarter of the promising descriptors picked by the feature selection algorithm, the five models achieved equivalent and comparable performance. Nevertheless, the contribution of all molecular descriptors in the models was investigated through the comparison of their rank values by the feature selection algorithm and found that the most potent and relevant descriptors which come from the ‘Autocorrelation’ module contributed more while the ‘Atom type electrotopological state’ contributed the least to the model.
MmpA, a Conserved Membrane Protein Required for Efficient Surface Transport of Trehalose Lipids in Corynebacterineae
Authors: Cashmore Tamaryn J. , Klatt Stephan , Brammananth Rajini , Rainczuk Arek K. , Crellin Paul K. , McConville Malcolm J. , Coppel Ross L.
Published: November 2021

Cell walls of bacteria of the genera Mycobacterium and Corynebacterium contain high levels of (coryno)mycolic acids. These very long chain fatty acids are synthesized on the cytoplasmic leaflet of the inner membrane (IM) prior to conjugation to the disaccharide, trehalose, and transport to the periplasm. Recent studies on Corynebacterium glutamicum have shown that acetylation of trehalose monohydroxycorynomycolate (hTMCM) promotes its transport across the inner membrane. Acetylation is mediated by the membrane acetyltransferase, TmaT, and is dependent on the presence of a putative methyltransferase, MtrP. Here, we identify a third protein that is required for the acetylation and membrane transport of hTMCM. Deletion of the C. glutamicum gene NCgl2761 (Rv0226c in Mycobacterium tuberculosis) abolished synthesis of acetylated hTMCM (AcTMCM), resulting in an accumulation of hTMCM in the inner membrane and reduced synthesis of trehalose dihydroxycorynomycolate (h2TDCM), a major outer membrane glycolipid. Complementation with the NCgl2761 gene, designated here as mmpA, restored the hTMCM:h2TDCM ratio. Comprehensive lipidomic analysis of the ΔtmaT, ΔmtrP and ΔmmpA mutants revealed strikingly similar global changes in overall membrane lipid composition. Our findings suggest that the acetylation and membrane transport of hTMCM is regulated by multiple proteins: MmpA, MtrP and TmaT, and that defects in this process lead to global, potentially compensatory changes in the composition of inner and outer membranes.
Selective Detection of an Infection Biomarker by an Osteo-Friend Scaffold: Development of a Multifunctional Artificial Bone Substitute
Authors: Kim Hye-In , Raja Naren , Choi Youngjun , Kim Jueun , Sung Aram , Choi Yeong-Jin , Yun Hui-suk , Park Honghyun
Published: November 2021

Developments in three-dimensional (3D) printing technologies have led to many potential applications in various biomedical fields, especially artificial bone substitutes (ABSs). However, due to the characteristics of artificial materials, biocompatibility and infection remain issues. Here, multifunctional ABSs have been designed to overcome these issues by the inclusion of a biochemical modality that allows simultaneous detection of an infection biomarker by osteo-friend 3D scaffolds. The developed multifunctional scaffolds consist of calcium-deficient hydroxyapatite (CDHA), which has a similar geometric structure and chemical composition to human bone, and gold nanoparticles (Au NPs), which assists osteogenesis and modulates the fluorescence of labels in their microenvironment. The Au NPs were subsequently conjugated with fluorescent dye-labeled probe DNA, which allowed selective interaction with a specific target biomarker, and the fluorescent signal of the dye was temporally quenched by the Au NP-derived Förster resonance energy transfer (FRET). When the probe DNA unfolded to bind to the target biomarker, the fluorescence signal was recovered due to the increased distance between the dye and Au NPs. To demonstrate this sensing mechanism, a microbial oligonucleotide was selected as a target biomarker. Consequently, the multifunctional scaffold simultaneously facilitated osteogenic proliferation and the detection of the infection biomarker.
Stratification for RRMM and Risk-Adapted Therapy: Sequencing of Therapies in RRMM
Authors: Jeryczynski Georg , Bolomsky Arnold , Agis Hermine , Krauth Maria-Theresa
Published: November 2021

The treatment landscape for relapsed multiple myeloma (RRMM) has experienced an unprecedented wave of innovation. Implementation of numerous new substances and drug classes with different modes of action is made possible in routine clinical practice. Next generation proteasome inhibitors, monoclonal antibodies, as well as first in class agents such as selinexor and venetoclax have widened the therapeutic spectrum. This has led to an increase in progression-free and overall survival. Consequently, new challenges for treating physicians in choosing the right treatment at the right stage of the disease have been generated. Several trials support the use of novel agents in the frontline treatment of newly diagnosed multiple myeloma. The use of lenalidomide or bortezomib as a backbone in the first-line setting, requires strategies for treatment once these patients relapse and are refractory to these drugs. Despite the variety of options, selecting the optimal treatment strategy is difficult, since multiple factors have to be considered: patient-specific factors such as age and co-morbidities, as well as myeloma/tumor specific factors such as cytogenetics and relapse kinetics. This review intends to summarize the existing data and guidelines regarding the optimal sequencing of treatments of RRMM using already approved agents as well as agents under investigation.
Differences in Uveal Melanoma Age-Standardized Incidence Rates in Two Eastern States of Australia Are Driven by Differences in Rurality and Ultraviolet Radiation
Authors: Chalada Melissa , Ramlogan-Steel Charmaine A. , Dhungel Bijay P. , Goh Amanda Y. , Gardiner Samuel , Layton Christopher J. , Steel Jason C.
Published: November 2021

Uveal melanoma (UM) is the second-most-common melanoma in humans and has a high age-standardized incidence rate (ASR) in Australia. Regional patterns of UM ASRs in Australia are unknown. The aim of this study was to determine and compare UM ASRs in two geographically disparate eastern states, Queensland (QLD) and Victoria (VIC), by using cancer registry data that was obtained from 2001 to 2013. World-standardized UM ASRs and incidence-rate ratios (IRRs) were calculated. Higher UM ASR was also observed in anterior UM compared to posterior UM ASR. UM ASR remained unchanged from 2001 to 2013 in QLD but decreased in VIC. A south-to-north latitude trend in UM ASR along the east of Australia is weakly evident, and rural populations have higher UM ASRs than major city populations in both states. Differences in ultraviolent radiation (UVR) susceptibility, indigenous populations, social behaviours, chemical exposure, and socioeconomic status could all be contributing to differences in UM rates between QLD and VIC and between rural compared to major city areas. It is possible that a minority of cases in QLD and VIC might be prevented by sun-protective behaviours. This is important, because these findings suggest that QLD, which is already known to have one of the highest cutaneous melanoma (CM) ASRs in the world, also has one of the highest UM ASRs.
Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases
Authors: Prochazkova Kristyna , Ptakova Nikola , Alaghehbandan Reza , Williamson Sean R. , Vaněček Tomáš , Vodicka Josef , Treska Vladislav , Rogala Joanna , Pivovarcikova Kristyna , Michalova Kvetoslava , Slisarenko Maryna , Hora Milan , Michal Michal , Hes Ondrej
Published: November 2021

(1) Background: There are limited data concerning inter-tumoral and inter-metastatic heterogeneity in clear cell renal cell carcinoma (CCRCC). The aim of our study was to review published data and to examine mutation profile variability in primary and multiple pulmonary metastases (PMs) in our cohort of four patients with metastatic CCRCC. (2) Methods: Four patients were enrolled in this study. The clinical characteristics, types of surgeries, histopathologic results, immunohistochemical and genetic evaluations of corresponding primary tumor and PMs, and follow-up data were recorded. (3) Results: In our series, the most commonly mutated genes were those in the canonically dysregulated VHL pathway, which were detected in both primary tumors and corresponding metastasis. There were genetic profile differences between primary and metastatic tumors, as well as among particular metastases in one patient. (4) Conclusions: CCRCC shows heterogeneity between the primary tumor and its metastasis. Such mutational changes may be responsible for suboptimal treatment outcomes in targeted therapy settings.
Propensity for Early Metastatic Spread in Breast Cancer: Role of Tumor Vascularization Features and Tumor Immune Infiltrate
Authors: D’Andrea Mario Rosario , Cereda Vittore , Coppola Luigi , Giordano Guido , Remo Andrea , De Santis Elena
Published: November 2021

Breast cancer is a complex and highly heterogeneous disease consisting of various subtypes. It is classified into human epidermal growth receptor 2 (HER-2)-enriched, luminal A, luminal B and basal-like/triple negative (TNBC) breast cancer, based on histological and molecular features. At present, clinical decision-making in breast cancer is focused only on the assessment of tumor cells; nevertheless, it has been recognized that the tumor microenvironment (TME) plays a critical biologic role in breast cancer. This is constituted by a large group of immune and non-immune cells, but also by non-cellular components, such as several cytokines. TME is deeply involved in angiogenesis, immune-evasion strategies, and propensity for early metastatic spread, impacting on prognosis and prediction of response to specific treatments. In this review, we focused our attention on the early morphological changes of tumor microenvironment (tumor vasculature features, presence of immune and non-immune cells infiltrating the stroma, levels of cytokines) during breast cancer development. At the same time, we correlate these characteristics with early metastatic propensity (defined as synchronous metastasis or early recurrence) with particular attention to breast cancer subtypes.
The Increase in Addiction during COVID-19
Authors: Daglis Theodoros
Published: November 2021

The increase in addiction during COVID-19 is a condition that emerged as an aftermath of COVID-19-related events, for instance, fear of the spread of COVID-19, self-abstention from many activities, and restrictions established by the lockdown measures. This condition includes substance addictions such as drugs and alcohol but also behavioral addictions such as gambling, gaming, pornography, and smartphone and internet misuse.
Cytotoxic and genotoxic effects of the ethanolic extract from the rind of the fruit of Sterculia striata St. Hil. & Naudin / Efeitos citotóxicos e genotóxicos do extrato etanólico da casca do fruto de Sterculia striata St. Hil. & Naudin
Authors: Cosme Marcos Vinícius , Oliveira Elisângela Cláudia Alves de , Melo Suyane de Deus e , Benko-Iseppon Ana Maria , Nery João Sammy Souza , Oliveira Aldeidia Pereira de
Published: November 2021

The species Sterculia striata A. St. Hil. Naudin has been used by the population in food and in the treatment of skin conditions, mainly for the treatment of boils. Recently, for this species has also been attributed an antioxidant, anti-inflammatory and antibacterial action. However, little is known about its cytogenotoxic potential. The present work aimed to evaluate the cytotoxic and genotoxic effects of the ethanolic extract from the rind of the fruit of Sterculia striata A. St. Hil. Naudin. Phytochemical analysis of the ethanolic extract was performed to determine the presence of secondary metabolites. Concentrations ranging from 0.1 to 1000 µg/ml of the ethanolic extract from the rind of the fruit Sterculia striata were tested for toxicity and cytotoxicity, by the Artemia salina bioassay and the MTT test, respectively. For the genotoxicity analysis, the Allium cepa test was used, at concentrations from 9 to 1000 µg/ml of the extract. All data were analyzed and compared to controls. The statistical test of analysis of variance (ANOVA with a fixed factor) was used, followed by Tukey's multiple comparisons test, for p0.05. Phytochemical screening revealed the presence of tannins, flavonones, flavonols, saponins, alkaloids, steroids and triterpenes. The results showed a decline in the survival rate at high concentrations, in the Artemia salina and MTT tests, the latter being more sensitive for presenting a significant reduction from the concentration of 81 µg/mL. As for the results obtained for the genotoxicity parameter, an increase in the number of chromosomal alterations in root cells exposed to concentrations was observed, also from 81 µg/ml, through the Allium cepa test. The main chromosomal alterations verified were delays, bridges and breaks, in metaphase and anaphase. Taken together, it can be concluded that the ethanolic extract of the rind of the fruit of Sterculia striata A. St. Hil. Naudin exhibits cytotoxic and genotoxic effects mainly at higher concentrations.
The Impact of Drug Trials With Financial Conflict of Interests on the Meta-analyses: A Meta-epidemiological Study
Authors: Zhang Na , Yan Peijing , Zhao Haitong , Feng Lufang , Chu Xiajing , Li Jingwen , Chen Nan , Yang Kehu , Liu Xingrong
Published: November 2021

Background: To assess the impact of trials with potential financial conflict of interests (FCOIs) on evidence synthesis in meta-analyses (MAs). Methods: A total of 96 MAs from the Cochrane Library about drug trials were investigated. The primary outcomes examined the proportion of conclusions that would change with the exclusion of trials with potential FCOIs. If the proportion of changed conclusions was below the non-inferiority margin of 10%, we considered that it was not inferior to include the trials with potential FCOIs in the MAs. Results: Only 54.17% of MAs reported the funding sources of each included trial, and in 21.88% of MAs, the author-industry-related financial ties of each included trial were reported. When trials with FCOIs were excluded, the changed conclusions of effectiveness and major adverse events were 13.16% and 11.11%, respectively, and the I2 decreased by 13.56% and 10.09%, respectively. For serious adverse events, the exclusion of FCOIs trials did not lead to any change in conclusions; however, the I2 decreased by 24.24%. The impact of trials without reported FCOIs was also examined on evidence synthesis, and the results showed that the changed conclusions of effectiveness and major adverse events were 5.26% and 6.25%, respectively, indicating non-inferiority. However, the I2 increased by 13.60% and 12.37%, respectively. Conclusion: In this meta-epidemiological study, we demonstrated that trials with FCOIs may not only influence the final outcome of MAs but may also increase the heterogeneity of results. It is suggested that all MAs fully report the FCOIs involved in evidence-based research and explore the impact of its FCOIs to better provide a more valuable reference for patients, clinicians, and policy-makers.
LANDSCAPE-ENVIRONMENTAL ASSESSMENT OF THE PARK TERRITORY OF CULTURAL HOUSE 50-YEARS OF OCTOBER, VORONEZH
Authors: Burmakina E. , Hazova Ekaterina
Published: November 2021

The results of the landscape-ecological assessment of the park territory of cultural house 50-years of October in Voronezh are presented. This work allows you to determine the state of the object for its further use. This facility is located in the South-West district of the city and is used for recreation of the local population. The indicators of landscape-ecological assessment were determined: type of landscape, type of spatial structure, sanitary-hygienic assessment, aesthetic assessment, stage of digression. The results of the research showed that the site is in a relatively good sanitary condition, the indicator of aesthetic assessment is at a fairly high level. We also studied the plant species, which grow on the object and their condition. The assortment available in the park is represented by the list of woody plants: Robinia pseudoacacia, Betula pendula, Ulmus pumila, Acer platanoides, Tilia cordata, Populus alba, Populus pyramidalis, Sorbus aucuparia.All woody plants in the park is in good and satisfactory condition. Based on the results of the assessment of the territory, it is possible to outline design measures that will improve the sanitary, hygienic and aesthetic conditions at the facility. There is a need to design small forms of architecture (benches, urns), organize additional planting of trees, pick up flowering shrubs and create flower beds to enhance the attractiveness of the object.
Macroporous thermoset monoliths from glycidyl methacrylate (GMA)-based high internal phase emulsions (HIPEs): Effect of cellulose nanocrystals (CNCs) as filler - Functionalization and removal of Cr(III) from aqueous solutions
Authors: Kekevi Burcu , Eşlek Ali , Mert Emine Hilal
Published: November 2021

Macroporous foams having 80 vol % of nominal porosity were synthesized by the copolymerization crosslinking of glycidyl methacrylate (GMA) based high internal phase emulsions (HIPEs). To alter the mechanical and thermal properties, cellulose nanocrystals (CNCs) were used as filler. For this purpose, CNCs were added to the continuous oil phase during emulsification process at a loading rate of 1, 5 or 7 wt %. Consequently, composite foams were obtained by purification of the polymerized HIPEs (polyHIPEs). The effect of CNCs on the morphological and mechanical properties was investigated. It was found that CNCs have a significant influence on the thermal stability and the compressive strength of the obtained foams. In the end, the neat polyHIPE foam and the polyHIPE/CNC composite foam with 1 wt % of CNC were post-functionalized by reacting phenylimidazole (PIAL) with the epoxy ring of the GMA units. Resulting amine functional foams and the neat foam were utilized in Cr(III) removal from aqueous solutions. It was demonstrated that amine functional foams have a great potential as sorbent materials. The results also showed that the existence of CNCs decreased the performance for removing Cr(III) ions. Nevertheless, functionalization by PIAL significantly improved the selectivity of Cr(III) in comperasion with the neat polyHIPE foam.
Designing Android Based Software for Anthropometry, Hearing test, and Visual Test to Monitor Children Developmental Status
Authors: Anakampun Zalni Rahmad , Nabilah Nabilah , Sonia Cut Hasina , Maulana Masdar , Parlindungan Firman , Firdaus Muhammad Reza
Published: November 2021

The World Health Organization (WHO) in 2018 reported that the prevalence for children under five with growth and development disorders was 28.7%, and Indonesia was included in the third country with the highest prevalence in the Southeast Asia region. As such, monitoring child growth and development is pivotal to determine necessary intervention and prevention. With technological advancement, monitoring child growth and development has become more accessible. The main objective of this paper is to explain the process of designing an Android software application for anthropometry, hearing test, and visual test to monitor children's developmental status. We employed to research and development methods, including need analysis, data collection, application design, user trial, and evaluation. The findings showed that the application could monitor growth and development in children from the age of zero to 72 months based on anthropometric testing related to auditory and visual stimulation in children. The application is useful in detecting the growth and development of children based on the results of the child's stimulation response. Based on the results of user trials by medical experts, parents, technological experts, it can be concluded that the software is applicable in monitoring the status of children's growth and development.
Rancang Bangun Sistem Kontrol dan Pemantauan Serikultur Menggunakan Mikrokontroler Berbasis Internet-of-Things
Authors: Alwaaritsi Bimo Fajrie , Tohir Toto , Aming Dedi
Published: November 2021

Rancang Bangun Sistem Kontrol dan Pemantauan Serikultur Menggunakan Mikrokontroler Berbasis Internet-of-Things
Evaluasi Kualitas Aset Destinasi Wisata Dayeuh Manggung Kabupaten Garut
Authors: Dewi Sania Oceana , Karnawati Hennidah
Published: November 2021

Evaluasi Kualitas Aset Destinasi Wisata Dayeuh Manggung Kabupaten Garut
Rewriting the Grammar of the Education System: Delhi’s Education Reform (A Tale of Creative Resistance and Creative Disruption)
Authors: Aiyar Yamini , Davis Vincy , Govindan Gokulnath , Kapoor Taanya
Published: November 2021

The study was not designed to undertake an evaluation of the success or failure of reform. Nor was it specifically about the desirability or defects of the policy reform choices. It took these reform choices and the policy context as a given. It is important to note that the Delhi reforms had its share of criticisms (Kumar, 2016; Rampal, 2016). However, our goal was not to comment on whether these were the “right” reforms or have their appropriateness measured in terms of their technical capability. This study sought to understand the pathways through which policy formulations, designed and promoted by committed leaders (the sound and functional head of the flailing state), transmit their ideas and how these are understood, resisted, and adopted on the ground. In essence, this is a study that sought to illuminate the multifaceted challenges of introducing change and transition in low-capacity settings. Its focus was on documenting the process of implementing reforms and the dynamics of resistance, distortion, and acceptance of reform efforts on the ground. The provocative claim that this report makes is that the success and failure, and eventual institutionalisation, of reforms depend fundamentally on how the frontline of the system understands, interprets, and adapts to reform efforts. This, we shall argue, holds the key to upending the status quo of “pilot” burial grounds that characterise many education reform efforts in India. Reforms are never implemented in a vacuum. They inevitably intersect with the belief systems, cultures, values, and norms that shape the education ecosystem. The dynamics of this interaction, the frictions it creates, and reformers’ ability to negotiate these frictions are what ultimately shape outcomes. In the ultimate analysis, we argue that reforming deeply entrenched education systems (and, more broadly, public service delivery systems) is not merely a matter of political will and technical solutions (although both are critical). It is about identifying the points of reform friction in the ecosystem and experimenting with different ways of negotiating these. The narrative presented here does not have any clear answers for what needs to be done right. Instead, it seeks to make visible the intricacies and potential levers of change that tend to be ignored in the rush to “evaluate” reforms and declare success and failure. Moving beyond success to understand the dynamics of change and resistance is the primary contribution of this study.
From full day learning to 30 minutes a day: A descriptive study of early learning during the first COVID-19 pandemic school shutdown in Ontario
Authors: Spadafora Natalie , Reid-Westoby Caroline , Pottruff Molly , Wang Jade , Janus Magdalena
Published: November 2021

When the COVID-19 pandemic was declared in March 2020, the lives of families all over the world were disrupted. Many adults found themselves working from home while their children were unable to go to school. To better understand the potential impact of these educational disruptions, it is important to establish what learning looked like during the first school shutdown in the spring of 2020, particularly for the youngest learners who may feel the longest lasting impacts from this pandemic. Therefore, the purpose of the current descriptive study was to gather information on how kindergarten teaching and learning occurred during this time, what the biggest barriers were, and what concerns educators had regarding returning in person to the classroom setting. The sample for the current study was 2,569 kindergarten educators (97.6% female; 74.2% teachers, 25.8% early childhood educators) in Ontario, Canada. Participants completed a questionnaire consisting of both quantitative scales and qualitative open-ended questions. Educators reported that parents most often contacted them regarding technological issues or how to effectively support their child. The largest barrier to learning was the ability of both parents and educators to balance work, home life, and online learning/teaching. With regards to returning to school, educators were most concerned about the lack of ability of kindergarten aged children to do tasks independently and to follow safety protocols. Our findings highlight unique challenges associated with teaching kindergarten during the pandemic, contributing to our understanding of the learning that occurred in Ontario during the first COVID-19 shutdown.
Diego Fallon Carrión: El poeta de la luna
Authors: Ortiz Bernal José Afranio
Published: November 2021

Crónica periodística de Diego Fallon, publicada en el volumen VII de Tolimenses que dejan huella. El nombre del poeta Diego Fallon Carrión aparece indeleble en la historia de la literatura colombiana y en varias antologías de la poesía latinoamericana, que incluyen siempre tres de sus poesías maestras: La palma del desierto, Las rocas de Suesca y por supuesto, La luna. Diego Fallon es uno de los precursores de la corriente poética de origen francés conocida como el Parnasianismo, y se constituyó como uno de los célebres representantes del Romanticismo en Colombia, cuando esta corriente ya había finalizado su ciclo en Europa.
Carmenza Rocha Castilla: Una vida al servicio de los demás
Authors: Hernández Quintero Hernando A.
Published: November 2021

Crónica periodística de Carmenza Rocha Castilla, publicada en el volumen VII de Tolimenses que dejan huella. Educadora, política, diplomática e impulsora de obras sociales que se destacó por su compromiso con la sociedad tolimense. Carmenza Rocha Castilla nació el 6 de julio de 1898, en el Chaparral de los Grandes. Entre sus logros se debe enfatizar en la creación del colegio Cooperativo, su labor como representante a la Cámara, concejal, embajadora, alcaldesa y líder indiscutible de grandes obras sociales.
Highly sensitive refractive index sensor for detection of Hg2+ based on Fano-like resonance in metal–dielectric–metal meta-structure
Authors: Yuan Shuangxiu , Sun Xuebo , Li Jing , Li Yan , Su Fufang , Wang Yinghua , Lv Chenghua , Kong Yilin , Zhang Xia
Published: November 2021

We experimentally and theoretically investigate Fano-like resonance in a large-area Au/SiO2/Au nano-patches meta-structure, which originates from the coupling between Fabry–Perot resonance and magnetic dipole resonance modes. A highly sensitive refractive index sensor based on the lineshape analysis is obtained. The extracted wavelength shift with the amount of substance of Hg2+ changing from 10–3 pmol to 1 nmol has a linear dependence, and the sensitivity can reach to ultra-low limit of detection (LOD) as 10–3 pmol. This study may provide an approach for the development and modification in sensing.
High-Frequency, low-voltage oscillations of dielectric elastomer actuators
Authors: Wiranata Ardi , Kanno Makoto , Chiya Naoki , Okabe Hozuma , Horii Tatsuhiro , Fujie Toshinori , Hosoya Naoki , Maeda Shingo
Published: November 2021

To increase safety and reduce the electric circuit cost, dielectric elastomer actuators (DEAs) must operate below the kV range. The simplest strategy to reduce the voltage operation is to decrease the dielectric elastomer membrane thickness. This research aims to demonstrate DEAs with a nanometric uniform thickness that can operate at a low voltage (below 70 V) and a high frequency. We use the roll-to-roll process to fabricate a 600 nm thick stretchable PDMS (polydimethylsiloxane) nanosheet and a 200 nm thick conductive nanosheet. These nanosheet-DEAs are tested in high-frequency operations of DC voltage below 70 V and in a frequency range of 1–30 kHz.
Application of FURIA for Finding the Faults in a Hydraulic Brake System Using a Vibration Analysis through a Machine Learning Approach
Authors: T. M Alamelu Manghai , R Jegadeeshwaran
Published: November 2021

Vibration-based continuous monitoring system for fault diagnosis of automobile hydraulic brake system is presented in this study. This study uses a machine learning approach for the fault diagnosis study. A hydraulic brake system test rig was fabricated. The vibration signals were acquired from the brake system under different simulated fault conditions using a piezoelectric transducer. The histogram features were extracted from the acquired vibration signals. The feature selection process was carried out using a decision tree. The selected features were classified using fuzzy unordered rule induction algorithm ( FURIA ) and Repeated Incremental Pruning to Produce Error Reduction ( RIPPER ) algorithm. The classification results of both algorithms for fault diagnosis of a hydraulic brake system were presented. Compared to RIPPER and J48 decision tree, the FURIA performs better and produced 98.73 % as the classification accuracy.
Újkígyós, Békés megye, Moldva
Authors: Halász Péter
Published: November 2021

Harangozó Imre: Napkeleti kalászat... Válogatott tanulmányok, írások, naplók, fényképek. Tortoma Könyvkiadó, Barót 2020. 240 old.
Változó létformák a határ- és kontaktzónában
Authors: Nagy Ákos
Published: November 2021

Vajda András: Változó létformák vidéken. Egy Maros menti falu gazdasági-kulturális szerkezetének átalakulása. (Dissertationes Ethnographicæ Transylvanicæ). Kriza János Néprajzi Társaság – L’Harmattan, Kvár – Bp. 2019. 327 old.
تأثير قانون الامتثال الضريبي الأمريكي (FTCA) على حماية السرية المصرفية
Authors: مصالحة تركي
Published: November 2021

أدت إعادة هيكلة النظام المالي العالمي الناتج عن انفتاح الأسواق المالية وتشعبها، إلى تغير العلاقات الدولية، خصوصًا المصرفية والمالية بسبب زيادة التحويلات المالية العابرة للدول، مما أدى إلى رفع درجة المخاطر الناتجة عن الجرائم المالية كالتهرب من الضرائب، وتبييض الأموال وتمويل الإرهاب، وبرزت الحاجة إلى إيجاد معايير جديدة وآليات للتعاون الدولي لمكافحتها، وإيجاد أُطر أكثر فعالية للتعاون بين الجهات كافة، وتمثّل ذلك في ظهور المعاهدات الدولية لتبادل المعلومات بين الدول وتشريعات الامتثال الضريبي، وتضييق الخناق على السرية المصرفية، لمنعها من أن تكون غطاء أو عقبة أمام شفافية المعلومات، وممارسة ضغوط على الدول وأنظمتها المالية غير المتعاونة لإجبارها على الامتثال.

ومن أمثلة نظم الامتثال الضريبي الـ «FATCA» الصادر في آذار/مارس (2010م) عن وزارة الخزانة الولايات المتحدة الأميركية، لتُلزم جميع مصارف العالم ودوله بتطبيقه تحت طائلة العقوبات الأميركية، والذي أصبح ساريًا اعتبارًا من بداية تموز /يوليو (2014م).
تداخل ظاهرة الهجرة غير الشرعية بجريمة الاتجار بالبشر واقع وتحديات
Authors: بن حليلو فيصل , حسن أحمد
Published: November 2021

تعد ظاهرة الهجرة غير الشرعية من المشاكل الخطيرة التي تواجه المجتمع الدولي برمته، والتي تتطور مع تطور العلاقات بين الدول؛ حيث كانت الهجرة قديمًا في ظل عدم وجود تنظيمات سياسية تبسط سلطتها على إقليم معين وتنظم عملية الدخول والخروج إليه، ومن ناحية أخرى، يعتبر الاتجار بالبشر ظاهرة دولية تمتد بين العديد من الدول المختلفة، وتختلف صورها وأنماطها من دولة لأخرى بحيث تشمل على سبيل المثال: الاتجار بالنساء والأطفال لأغراض الدعارة والاستغلال الجنسي وبيع الأعضاء البشرية و ....، وتمارسها عصابات الجريمة المنظمة وتدر أرباحًا خيالية لهذه المنظمات الإجرامية المنظمة على حساب الحط من كرامة الإنسان وإيذائه جسديًا ونفسيًا.

ويهدف هذا البحث إلى تبيان واقع الهجرة غير الشرعية وأثرها على انتشار جريمة الاتجار بالبشر دوليًا، وبيان حقوق المهاجرين غير الشرعيين كضحايا لجريمة الاتجار بالبشر، وبيان كيفية التصدي لجريمة الاتجار بالبشر الناتجة عن ظاهرة الهجرة غير الشرعية من خلال تناول الاتجار بالبشر في بروتوكول منع وقمع ومعاقبة الاتجار بالبشر وخاصة النساء والأطفال، (بروتوكول بالريمو2000) المكمل لاتفاقية الأمم المتحدة لمكافحة الجريمة المنظمة عبر الوطنية وبروتوكول مكافحة تهريب المهاجرين، وبيان دور دولة الإمارات في مكافحتها لهذه الظاهرة، ومدى تطابق القانون الإماراتي بالاتفاقيات الدولية، لا سيما بروتوكول باليرمو وبروتوكول مكافحة تهريب المهاجرين.
Analisis Tata Ruang Penyimpanan Berkas Rekam Medis dan Informasi Kesehatan di Rumah Sakit X Kota Bandung 2020
Authors: Ain Sodikin Risma Nurul , Sari Irda
Published: November 2021

Latar Belakang: Rekam medis dilaksanakan oleh unit rekam medis yang salah satunya yaitu filing yang merupakan penyimpanan berkas rekam medis yang berfungsi untuk menyimpanan, penyiapan dan pelindung kerahasiaan berkas rekam medis. Penyimpanan berkas rekam medis akan berjalan dengan baik apabila adanya fasilitas yang memadai seperti rak penyimpanan yang memadai agar berkas tertata dengan baik dan juga dapat pula mempermudah petugas untuk pencarian berkas dan pengambilan serta penyimpanan kembali berkas rekam medis.
Tujuan: Penelitian ini bertujuan untuk menganalisa tata ruang penyimpanan berkas rekam medis meliputi tinggi rak, panjang rak, lebar rak, jarak antar rak dan luas ruangan rekam medis.
Metode: Penelitian ini menggunakan desain penelitian deskriptif. Desain penelitian yang digunakan adalah observasi atau pengamatan langsung dan wawancara. Waktu penelitian ini dilaksanakan pada bulan april 2021 – juni 2021. Ruang filing di rumah sakit X kota bandung memiliki 14 rak yang panjang raknya berbeda – beda setelah di hitung dan memiliki rata – rata 192,5 cm, lebar 38cm, tinggi rak 2,50 cm, rata -  rata jarak antar rak yaitu 74 cm dan luas ruang penyimpanan 102 m2.
Hasil: Berdasarkan hasil perhitungan luas ruang penyimpanan berkas rekam medis di rumah sakit X kota bandung dari jarak antar rak 90 cm maka luas ruang penyimpanan yang di butuhkan untuk menyimpan 19 unit rak baru jenis kayu 62,78 m2.
Kesimpulan: Kesimpulan dari penelitian ini bahwa analisa tempat penyimpanan yang baik di rumah sakit X kota bandung membutuhkan luas ruang 62,78 cm2..