bluuebunny/crossref_metadata_2025 huggingface dataset:
F.L. Tuma on the February and October Revolutions in Russia
Authors: Kirilina Ljubov Aleksejevna
Published: April 2019

The article examines some still unexplored aspects of the Slovenian attitude to the February and October revolutions in the Russia of 1917. The research was carried out primarily on the basis of press materials – memoirs of the Slovenian patriot Tuma, which were published in twenty issues of a Trieste newspaper, Edinost, in 1919. Tuma’s notes are very important sources for studying this topic, in particular because he was the only Slovenian intellectual and patriot who spent almost the entire time of the First World War, from 1914 to 1918, in Petrograd. He was also the only Slovenian who had access to the Russian government. The goal of the study is to reveal the peculiarities of the Slovenian perception of Russian reality during the two revolutions and to assess the objectivity of Tuma’s attempts at analysis. The conclusion is that, although he was an eyewitness of great events, his judgments cannot be regarded as completely objective. On the other hand, the publication of Tuma’s memoirs undoubtedly helped to shape a matrix of Slovenian notions about Tsarist and Bolshevik Russia.
Gripping the Gripped: Removal of Foreign Bodies from Root Canal System
Authors: Jain Shweta , Jain Sachin , Jain Shikha , Thakur Sophia
Published: April 2019

Introduction: Presence of foreign body in the root canal system is a troublesome situation as they prevent the access to thorough root canal cleaning and shaping procedure apical to their level. They might also irritate the periapex when they protrude out of the root apex. This affects final outcome of endodontic therapy. Hence an attempt to bypass or retrieval of the foreign body should be made before leaving and obturating till the level of their presence or proceeding to surgery. The procedure for removal will vary depending on the nature of the foreign body and its position within the canal. Many different devices and techniques have been developed to retrieve foreign bodies from the root canal system, but none of them can consistently remove them from the canals. Case Presentation: Three cases requiring removal of foreign bodies from the different positions in the canals are presented. These cases present the conservative management of an inadvertently lodged foreign body in the root canal system during a routine dental procedure and describe the management strategies for their retrieval. Conclusion: Provided one has good patient cooperation, management of the situation can be quite straight forward if the appropriate diagnostic and treatment tools are utilized.
Wound Healing
Authors: Mushtaq Bushra
Published: April 2019

Wound
In simple terms wound is break in the continuity of tissue caused by any trauma or injury. There are many types of wounds like; puncture wound, abrasions, lacerated etc.

Healing
Healings is the response of body to the trauma or injury for restoring the damage caused. This healing involves two main processes
Regeneration: In this process the total formation or regeneration of parenchymal cells occurs which results in restoration of the tissue.
Repair: In this process the scar is usually formed.
Electrocardiogram Interpretation: An Exploration of Knowledge and Practice among Secondary Care Hospital's Emergency Physicians
Authors: Hussain Aamir
Published: April 2019

Background: An electrocardiogram (ECG) is a simple, easy, low cost and routine diagnostic tool. Nearly all private secondary hospitals of Pakistan have this facility. It is non-invasive, cardiac evaluation test. It has unsophisticated handling procedure. It is very important for duty doctors in their busy clinical practice to have good command on ECG interpretation. Likewise it is prime responsibility of doctors to timely order the ECG when warranted. A good physician has to interpret ECG precisely for timely manage and refer the cardiac related patients to tertiary care facility. Aim and Objectives: The aim of this study was to take a survey among the secondary level private hospital doctors, regarding their knowledge and interpretation skills for timely decision making. Methodology: Total five lethal ECGs were recorded and distributed among 470 doctors, working in the emergency departments of 12 private secondary hospital, of Karachi city, in different shifts from June, 2017 to December, 2017. They were asked to give only one diagnosis with at least five interpretation points to support their diagnosis. The answers were matched with definite diagnosis made by a cardiologist who has more than 15 years experience and currently working as Professor in cardiology. Results: Almost all of the doctors (93%) had readily asked for ordering an ECG for certain epigastric and chest pain evaluation. However, only 30% given the correct diagnosis regarding the lethal cardiac conditions. Interestingly, only 23% rightly interpret the lethal ECGs. Conclusion: According to results shown, the doctors working in private secondary hospitals of Karachi city were good at initiating the ECG recording order. However, ER doctors are advised strongly to gain in depth knowledge and correct interpretation skills as it can save millions of lives in their career.
Memory-Making in Kiruna - Representations of Colonial Pioneerism in the Transformation of a Scandinavian Mining Town
Authors: Overud Johanna
Published: April 2019

This article considers colonial rhetoric manifested in representations of early settlement in the mining town of Kiruna in northernmost Sweden. Kiruna was founded more than 100 years ago by the LKAB Company with its centre the prosperous mine on Sami land. Continued iron ore mining has made it necessary to relocate the town centre a few kilometres north-east of its original location to ensure the safety of the people. The ongoing process of the town’s transformation due to industrial expansion has given rise to the creation of a memorial park between the town and the mine, in which two historical photographs have been erected on huge concrete blocks. For the Swedish Sami, the indigenous people, the transformation means further exploitation of their reindeer grazing lands and forced adaption to industrial expansion. The historical photographs in the memorial park fit into narratives of colonial expansion and exploration that represent the town’s colonial past. Both pictures are connected to colonial, racialised and gendered space during the early days of industrial colonialism. The context has been set by discussions about what Kiruna “is”, and how it originated.

My aim is to study the role of collective memory in mediating a colonial past, by exploring the representations that are connected to and evoked by these pictures. In this progressive transformation of the town, what do these photographic memorials represent in relation to space? What are the values made visible in these photographs? I also discuss the ways in which Kiruna’s history becomes manifested in the town’s transformation and the use of history in urban planning. I argue that, in addressing the colonial history of Kiruna, it is timely to reconsider how memories of a town are communicated into the future by references to the past. I also claim that memory, history, and remembrance and forgetting are represented in this process of history-making and that they intersect gender, class and ethnicity.
Black, LGBT and from the Favelas: an Ethnographic Account on Disidentificatory Performances of an Activist Group in Brazil
Authors: Mascarenhas Neto Rubens , Zanoli Vinícius
Published: April 2019

In this article, we address the processes of the production of places, identities, and cultures through analysing performances of activists from Aos Brados, in their political activities throughout Campinas, a 1 million inhabitants city located in the state of São Paulo, Brazil. Aos Brados is an activist group formed by Black LGBT people from the favelas whose main activities in the last ten years have been cultural activities. Focusing on the activities made by Aos Brados members in cultural centres and public spaces throughout Campinas, we discuss how, in such presentations, the group disputes meanings associated with the places and cultures that these places claim to represent. We sustain that it can be seen as a process of disidentification in which Aos Brados reshapes meanings associated with places and cultures, producing Black LGBT Culture from the favelas. The discussion results from shared questions in two different research concerning the effects of the intersections of race, gender, class, and sexuality on the political identity of Black LGBT activists and on the performances of young drag queens. The methodology employed congregated participant-observation and in-depth interviews.
Narratives of a Fractured Trust in the Swedish Model: Tenants’ Emotions of Renovation
Authors: Polanska Dominika V. , Richard Åse
Published: April 2019

Research shows there is a current wave of housing renovation in Swedish cities, where private as well as public rental housing companies use “renoviction,” or displacement through renovation, as a profit-driven strategy. This article focuses on emotions and renoviction, in particular the emotions of tenants currently facing forced renovations, in Sweden. We discuss how power is reproduced and questioned, and illustrate methods used by housing companies to carry out extensive renovation. The following questions have guided our analysis: What kinds of emotions are evoked among tenants experiencing an extensive, top-down and costly renovation? What particular injustices and violations are identified by the tenants in this situation? How can these violations be understood in relation to the current housing policy? Our research is qualitative and builds on semi-structured interviews with tenants as well as extensive ethnographic work in a neighborhood undergoing renovation, followed by steeply increased rents. We use the metaphor of “fractured trust” to conceptualize the emotional reaction of tenants, and argue that citizens´ trust in the Swedish welfare system is being broken locally, in the wake of ongoing top-down renovation processes, by use of a rationality that does not take into consideration tenants’ perspectives and needs. We conclude that anxiety, angst, anger, and loss, attached together in a common feeling of shock, were the most prevalent emotions expressed and were described by tenants as a response to unfair treatment. In the interviews, a complex set of violations performed by the housing company in a renoviction neighborhood is brought to the forefront here, and set in this context of systemic violence exerted against tenants in contemporary Sweden.
Culture Unbound Vol. 11 Editorial
Authors: Hemmungs Wirtén Eva , Meese James , Dahlin Johanna , Olsson Jesper
Published: April 2019

No abstract available.
Traditional and Complementary Medicine Methods
Authors: Unal Merve , Dagdeviren Hamdi Nezih
Published: April 2019

World Health Organization describes traditional and complementary medicine as “the sum total of the knowledge, skills and practices based on the theories, beliefs and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health, as well as in the prevention, diagnosis, improvement or treatment of physical and mental illnesses”. The use of traditional and complementary medicine has a long history. As a result of increasing life expectancy of people, chronic and malignant diseases increases. Because of health care workers can not allocate enough time and the reasons such as avoiding the side effects of drugs, patients have increased interest in traditional and complementary medicine methods. It is predicted that the use of these methods will increase even more over time. To protect people from the harmful effects of these methods and to prevent unauthorized use, a variety of arrangements have been made in Turkey and in the world. For this reason, on October 27, 2014 "Regulations of Traditional and Complementary Medicine Practices" was published. In this regulation, 15 methods are accepted and their usage areas are expressed. These are phytotherapy, mesotherapy, maggot therapy, prolotherapy, cupping therapy, music therapy, hypnotherapy, homeopathy, hirudotherapy, ozone therapy, osteopathy, reflexology, acupuncture, apitherapy and chiropractic. Generally, patients do not tell their physician that they are using one of these methods. No matter what causes people to use these methods, if they use them unconsciously; diagnosis of diseases may be delayed, side effects may occur, or patients may be damaged by persons who are not authorized to perform these methods. For this reason, physicians should be aware of the tendencies of their patients and protect them from misuse by increasing their awareness.
Esperanzas y temores frente al proceso de paz en Colombia
Authors: Cifuentes Garzón José Eduardo , Rico Cáceres Sandra Patricia , Casallas Circa Andrés , Rodríguez Forero Marcela
Published: April 2019

Este artículo responde al objetivo de investigación: visibilizar las esperanzas y temores frente al proceso de paz en Colombia de estudiantes de educación básica secundaria, a fin de generar acciones de transformación en la construcción de una cultura de paz en contextos escolares. El estudio es cualitativo con investigación exploratoria. Se utilizaron como instrumentos el protocolo de esperanzas y temores y la rutina de pensamiento color, símbolo, imagen, de los cuales se derivan las percepciones sobre el proceso de paz, confrontadas con las interacciones y diálogos suscitados en el aula de clase. En la sistematización y análisis, se transcribió la información y por medio del análisis de contenido, se identificaron y desarrollaron las categorías emergentes. Para los estudiantes, las esperanzas frente al proceso de paz giran en torno a la recuperación de la tranquilidad en las comunidades. Los temores están centrados en el posible retorno a la cultura del miedo.
Procesos de generalización: Una vía de acceso al pensamiento algebraico temprano en Educación Básica
Authors: Butto Zarzar Cristianne Maria , Delgado Fernandez Joaquin , Bazán Ramirez Aldo
Published: April 2019

Se reportan resultados de un estudio sobre los procesos de generalización como una vía de acceso a la introducción temprana al pensamiento algebraico, con 109 estudiantes de educación básica de escuelas públicas, México. El trabajo experimental consistió de tres etapas: 1. Evaluación inicial sobre procesos de generalización, 2. Validación de un instrumento sobre procesos de generalización, 3 Entrevista clínica abierta. Los resultados  muestran que  los alumnos logran comprender ideas básicas de variación proporcional, describir un patrón y formular una regla general, a medida que transitaban del pensamiento aditivo al multiplicativo En lo que respecta al instrumento de evaluación, éste posee validez convergente y divergente de constructo.
Manejo de clase en un centro binacional: desarrollo profesional
Authors: Novozhenina Alexandra
Published: April 2019

Este artículo presenta los resultados de una investigación acción-participativa que se llevó a cabo en un centro binacional; el objetivo principal era identificar la forma efectiva del desarrollo profesional acerca del manejo de la clase. Participaron en el proyecto treinta y cinco profesores de nivel de inglés B2/C1, licenciados o con certificados de cursos de enseñanza. Finalmente, se pudo concluir que, aunque los talleres pueden enseñarles a los profesores conceptos importantes sobre el manejo de la clase, éstos no los animan a reflexionar sobre sus prácticas. Sin embargo, las estrategias proactivas como la grabación de clases y la observación de los compañeros pueden conducir a un proceso reflexivo y, por consiguiente, a mejorar la labor que hace docente.
Uso de Audifonos en Adultos Mayores: Factores personales y ambientales involucrados
Authors: Castillo Yuly Miley , Ibarra Ana Milena , Viveros Diana Carolina , Ujueta Ada
Published: April 2019

Teniendo en cuenta las diversas opiniones de aceptación y/o rechazo que se atribuye al proceso de adaptación de audífono en la población adulta mayor, se pretende encontrar los factores personales y ambientales que inciden en el tipo de impacto, positivo o negativo, que este proceso tuvo lugar en relación a su calidad de vida. Para lo anterior se aplicarán encuestas a un grupo de adultos mayores de que edad quienes hayan recibido esta atención, el familiar más cercano quien haga parte de su vida cotidiana y Audiólogos con experiencia en el proceso de adaptación de audífono en esta población. Con los resultados obtenidos se realizará un cruce de información que permitirá determinar, mediante un estudio cualitativo, cuál es la relación entre la experiencia y realidad del uso de audífonos teniendo en cuenta los tres puntos de vista determinantes y partícipes en este proceso.
Características Vocales de un Grupo Docente: Universidad Metropolitana de Barranquilla
Authors: Vargas Garcia Miguel Antonio , Muñoz Hernández Monica Patricia
Published: April 2019

Objetivo: establecer los parámetros de voz normal en un grupo de profesionales de la salud vinculados a la Universidad Metropolitana de Barranquilla. Método: El diseño muestral planteado fue no probabilístico por disposición; desde la metodología procedimental el grupo docente seleccionado fue filtrado a través de una primera evaluación anatómica y funcional realizada por otorrinolaringología. No fueron aceptados como participantes sujetos con cirugía de cuello. Resultados: el 73.3% de los evaluados presentan características de mal uso de la voz, dado que los resultados de la energía están disminuidos, factor que puede causar enfermedades ocupacionales. Estos docentes que presentan la particularidad de energía disminuida, están generando a partir del ataque vocal un esfuerzo cuando inician la fonación. Conclusiones: los resultados indica que el cuerpo docente evaluado, presenta serios factores de mal uso y abuso vocal, aspecto de relevancia teniendo en cuenta la labor docente y la voz como herramienta para su desempeño. Los factores evidenciados permiten concluir que los docentes no están haciendo uso de técnicas de manejo de la voz, quizás por desconocimiento. Es imprescindible que como estructura organizativa, la Universidad Metropolitana inicie procesos de capacitación en el manejo de la voz y del uso saludable de su instrumento de trabajo.
Cociente de Contacto (CQ) y Frecuencia Fundamental (Fo) en Profesionales de la Voz: [estudio piloto]
Authors: Jerez Rodrigo Maximiliano
Published: April 2019

El objetivo del presente estudio es evaluar los efectos de la edad y el género en el comportamiento vibratorio de los pliegues vocales durante la emisión de una vocal sostenida en tres grupos etarios definidos de profesionales de la voz basado en valores obtenidos por medio de electroglotografía (EGG). Participaron de este estudio 40 sujetos (25 mujeres y 15 varones) divididos en tres grupos. Los parámetros de análisis fueron cociente de contacto (CQ) y frecuencia fundamental (Fo). No se reportaron relaciones significativas entre las variables en cuestión. Los hallazgos sugieren que un uso adecuado de la voz sumado a un entrenamiento sistemático, tal como en el caso de las voces profesionales, tiene un impacto positivo y podría favorecer la conservación de la función vocal luego de iniciado el proceso normal de envejecimiento.
Infantes en situación de discapacidad: Caracterización de Población en el Valle del Cauca (2009-2014)
Authors: Aguilar Arias Andrea , Bolaños Rojas María Eugenia , Gómez Valderrama Anyi Paola , Gutiérrez Candela Daniela Alejandra , Lis Primero Ana María , Villota Fernández Lizet Dayana
Published: April 2019

El presente estudio da cuenta de un ejercicio de investigación, que surge a partir de la necesidad de analizar la información existente sobre discapacidad en primera infancia en el Valle del Cauca recogida mediante el Registro de Localización y Caracterización de Personas con Discapacidad –RLCPD- por medio de una alianza entre la Secretaría Departamental de Salud y del Programa Académico de Fonoaudiología de la Universidad del Valle. Se realiza un estudio descriptivo que tiene como objetivo la caracterización de tres macrocategorías de análisis (1) Factores sociodemográficos, (2) deficiencia y (3) situación de discapacidad y se desarrolló en cuatro fases: 1. Obtención de la fuente de información, 2. Revisión inicial, 3. Análisis preliminar y 4. Análisis y reporte detallado de la base de datos. Algunos de los resultados de este estudio evidenciaron un reporte de información completo y disponible sobre la población infantil con discapacidad para el periodo de estudio en 23 de los 42 municipios del departamento (N= 555) y contribuyen a la generación de acciones que den respuesta a las necesidades de esta población. Además, fortalece la ejecución de proyectos y programas encaminados a la atención integral a los niños entre 0 y 5 años.
Calidad de vida en adultos en situación de discapacidad: características sociodemográficas en Sincelejo (Sucre, Colombia)
Authors: Gil Obando Lida Maritza , López López Alexandra , Aguas de la Ossa María Margarita , Hernández Blanco Martha Lucía
Published: April 2019

Introducción: Las características sociodemográficas son determinantes en la percepción que tiene un individuo sobre los impactos de una condición de salud y discapacidad en su calidad de vida. Objetivo: Relacionar variables sociodemográficas con calidad de vida de personas adultas con discapacidad de la ciudad de Sincelejo, Colombia. Materiales y Método: Estudio correlacional, muestra conformada por 125 personas con discapacidad, mayores de 20 años con más de seis meses de la limitación, para la evaluación de calidad de vida relacionada con la salud se utilizó el WHOQOL BREF. Resultados: Los mejores promedios de puntuación de calidad de vida fueron para los dominios de relaciones interpersonales (68.6 ±14.7308) y psicológico (66.90±17.8847). Al analizar la calidad de vida por dominios con las variables sociodemográficas se encontró que hay una correlación fuerte positiva entre la variable sociodemográfica ocupación actual y los dominios: físico, psicológico y pelaciones interpersonales de calidad de vida. Conclusión: Las personas con discapacidad del estudio en su mayoría fueron hombres, solteros, pertenecientes al estrato 1, con un nivel máximo de estudios alcanzados de secundaria completa y trabajan por su propia cuenta. La ocupación evidenció mayor repercusión sobre la puntuación de calidad de vida general.
Association between occupational voice use and occurrence of voice disorders: a meta-analysis
Authors: Cantor Cutiva Lady Catherine
Published: April 2019

Purpose: This meta-analysis has two aims: 1) to provide a quantitative assessment of the occurrence of voice disorders among different occupational voice users, 2) and to determine whether being an occupational voice user (teacher, broadcaster, call-center worker, etc.) is associated with an increased occurrence of voice disorders. Method: A random-effect meta-analysis of the available scientific literature was conducted on the occurrence of voice disorders among occupational voice users. Comprehensive literature searches were conducted using two computerized databases: PubMed/MEDLINE, and Scielo. As a measure of association, the odds ratio (OR) with corresponding 95% confidence interval (95% CI) was used. Heterogeneity was assessed by chi-square and I2 and draw in forest plots. Results: Voice disorders are related with occupational voice use independently of type of prevalence with a pool OR of 2.39 for current voice disorders, 1.88 for 12-months prevalence, and 2.43 for life-time and unspecified recall period. Heterogeneity test (I2) among these articles is 68% for current voice disorders, 0% for 12-months voice disorders, and 66% for life-time and unspecified recall period. Although around 70% of the total number of included publications assessed the occurrence of voice disorders among teachers as occupational voice users, an analysis per occupation was performed to identify possible influence of this factor in the occurrence of voice disorders. Studies that include just teachers as the group of occupational voice users (n=12) reported ORs ranging from 1.20 to 4.61. Heterogeneity test (I2) among these articles is 17%. Studies that include telemarketers, newsreaders, and sellers as the group of occupational voice users (n=6) reported ORs ranging from 0.85 when future vocal professionals were compared future non-vocal professionals to 4.58 when newsreaders were compared with non-newsreaders. Heterogeneity test (I2) among these articles is 40%. Conclusion: Occupational voice users have a higher likelihood of having voice disorders. Results of this meta-analysis show that teachers had a slightly lower likelihood (pool OR=1.95) than telemarketers, broadcasters, and sellers (pool OR=2.75) for having a voice disorder regardless the type of prevalence. Nevertheless, due the weak to moderate quality of the included studies, the results should be taken with caution.
La voz de la mujer transexual y el efecto de doble mirada
Authors: Sauca i Balart Andreu
Published: April 2019

El incremento en la visibilización de las personas Transgénero, y el aumento de los logopedas que se especializan en logofoniatría, hacen que empiece a ser habitual la demanda de nuestros servicios de reeducación vocal por parte de personas transexuales Por el efecto de la doble mirada, estas se sienten más vulnerables y se acentúa la sensación de estar lejos del género sentido. Aun cuando ya puedan haber conseguido la imagen física deseada, ven cómo esta imagen física adquirida no les sirve si utilizan la voz.
Atención fonoaudiológica vocal a actores: La opción (o necesidad) de aportar en la promoción de su bienestar vocal-emocional
Authors: Azocar Fuentes María Josefina
Published: April 2019

En voz, la fonoaudiología se dedica a la rehabilitación y habilitación vocal. Desde una perspectiva biopsicosocial, debiese enfatizar en ambos contextos, en la salud y bienestar comunicativo a partir de la voz.En ese contexto, el propósito de este artículo es hacer una reflexión en torno a las posibilidades que tiene la fonoaudiología de generar espacios de exploración vocal-emocional en instancias de habilitación vocal con la intención de enriquecer la construcción de sí mismo del artista, favoreciendo su salud, bienestar y desarrollo profesional. Para ello, se expone teóricamente a los conceptos de ser y bienestar en la salud y la actuación, como marco para proponer que la habilitación vocal puede ser un espacio para profundizar en el conocimiento y la expresión de sí mismo, favoreciendo la calidad de vida y la creación escénica del Performer (salud en actividad y participación).Lo anterior repercute en dos líneas como responsabilidad ética: la necesidad de formación del fonoaudiólogo de voz como acompañante/guía de una proceso que apunta más allá del abordaje de aspectos técnico-vocales y la necesidad de generar evidencia del enfoque propuesto desde la vereda disciplinar.
Guía para el fonoaudiólogo en evaluación e intervención de la disfonía por tensión muscular: Revisión y caso
Authors: Peña Sánchez Martha Janneth
Published: April 2019

La disfonía por tensión muscular es uno de los diagnósticos comunes en la clínica de voz y el fonoaudiólogo o vocólogo es parte fundamental del equipo multidisciplinar encargado de su manejo. El propósito de este artículo es realizar una descripción de la disfonía por tensión muscular dentro del espectro de las denominadas disfonías funcionales. En la primera parte se presentan las diversas denominaciones, clasificaciones y características de las disfonías por tensión muscular que pueden servir como guía para el terapeuta en el proceso de evaluación e intervención terapéutica de las personas con alteraciones vocales por tensión muscular. En la segunda parte se presenta un caso para el cual se describe la intervención terapéutica realizada analizando los factores asociados, se discuten los resultados y la eficacia del tratamiento. La terapia basada en la coordinación y balance de los sistemas fisiológicos vocales puede ser una herramienta efectiva en la resolución de casos de disfonía por tensión muscular
New computational studies to support cyclin-dependent kinase 9 inhibitor screening and design
Authors: Fábián Márk , Balogh Balázs , Czudor Zsófia , Őrfi László
Published: April 2019

Aims: Cyclin-dependent kinase 9 (CDK9) plays a major role in the regulation of transcription. Its overexpression -which occurs in several types of cancer- increases the levels of certain antiapoptotic proteins that can lead to tumorigenesis, therefore the identification of new, more potent and more selective inhibitors is essential.

Methods: In this study we present a computational approach, which can facilitate lead selection and optimization.

Results: First, a pharmacophore hypothesis based on the active compounds has been developed to identify the key features for the ligand-target interaction. This was followed by the docking of the compounds into the active site of CDK9, the poses and interactions with the amino acids were compared with those of the co-crystallized ligand. The mode of their binding further explained the characteristics of these inhibitors while the docking scores can be a factor in the selection of active compounds in the future. Finally, a field-based QSAR model was also created, to predict the activity of inhibitor candidates.

Conclusion: With our current work we deepened our knowledge about the interactions between CDK9 and its inhibitors, which can contribute to the discovery of novel CDK9 inhibitors.
Effect of Tillage Systems on Spatial Variation in Soil Chemical Properties and Winter Wheat (Triticum aestivum L.) Performance in Small Fields
Authors: Hausherr Lüder Ruth-Maria , Qin Ruijun , Richner Walter , Stamp Peter , Streit Bernhard , Noulas Christos
Published: April 2019

To investigate how tillage intensity modifies the small-scale spatial variability of soil and winter wheat parameters, field trials were conducted on small plots (12 m × 35 m) in three temperate environments in the Swiss midlands: Zollikofen in 1999 (loamy silt soil; Gleyic Cambisol) and Schafisheim in 1999 and in 2000 (sandy loam soil; Orthic Luvisol). Total soil nitrogen (Ntot), total carbon (Ctot) and pH were assessed after harvest. A regular nested grid pattern was applied with sampling intervals of 3 m and 1 m at 0–30 cm on a total of nine no-tillage (NT) and nine conventional tillage (CT) plots. At each grid point, wheat biomass, grain yield, N uptake and grain protein concentration were recorded. Small-scale structural variance of soil Ntot, Ctot and pH was slightly larger in NT than in CT in the topsoil in the tillage direction of the field. Wheat traits had a slightly greater small-scale variability in NT than in CT. Spatial relationships between soil and crop parameters were rather weak but more pronounced in NT. Our results suggest limited potential for variable-rate application of N fertilizer and lime for NT soils. Moderate nugget variances in soil parameters were usually higher in CT than in NT, suggesting that differences in spatial patterns between the tillage systems might occur at even smaller scales.
Modeling Carbon and Water Fluxes of Managed Grasslands: Comparing Flux Variability and Net Carbon Budgets between Grazed and Mowed Systems
Authors: Puche Nicolas , Senapati Nimai , Flechard Christophe R. , Klumpp Katia , Kirschbaum Miko U.F. , Chabbi Abad
Published: April 2019

The CenW ecosystem model simulates carbon, water, and nitrogen cycles following ecophysiological processes and management practices on a daily basis. We tested and evaluated the model using five years eddy covariance measurements from two adjacent but differently managed grasslands in France. The data were used to independently parameterize CenW for the two grassland sites. Very good agreements, i.e., high model efficiencies and correlations, between observed and modeled fluxes were achieved. We showed that the CenW model captured day-to-day, seasonal, and interannual variability observed in measured CO2 and water fluxes. We also showed that following typical management practices (i.e., mowing and grazing), carbon gain was severely curtailed through a sharp and severe reduction in photosynthesizing biomass. We also identified large model/data discrepancies for carbon fluxes during grazing events caused by the noncapture by the eddy covariance system of large respiratory losses of C from dairy cows when they were present in the paddocks. The missing component of grazing animal respiration in the net carbon budget of the grazed grassland can be quantitatively important and can turn sites from being C sinks to being neutral or C sources. It means that extra care is needed in the processing of eddy covariance data from grazed pastures to correctly calculate their annual CO2 balances and carbon budgets.
An Ultrashort-Term Net Load Forecasting Model Based on Phase Space Reconstruction and Deep Neural Network
Authors: Mei Fei , Wu Qingliang , Shi Tian , Lu Jixiang , Pan Yi , Zheng Jianyong
Published: April 2019

Recently, a large number of distributed photovoltaic (PV) power generations have been connected to the power grid, which resulted in an increased fluctuation of the net load. Therefore, load forecasting has become more difficult. Considering the characteristics of the net load, an ultrashort-term forecasting model based on phase space reconstruction and deep neural network (DNN) is proposed, which can be divided into two steps. First, the phase space reconstruction of the net load time series data is performed using the C-C method. Second, the reconstructed data is fitted by the DNN to obtain the predicted value of the net load. The performance of this model is verified using real data. The accuracy is high in forecasting the net load under high PV penetration rate and different weather conditions.
A Novel Frequency Domain Visible Light Communication (VLC) Three-Dimensional Trilateration System for Localization in Underground Mining
Authors: Dehghan Firoozabadi Ali , Azurdia-Meza Cesar , Soto Ismael , Seguel Fabian , Krommenacker Nicolas , Iturralde Daniel , Charpentier Patrick , Zabala-Blanco David
Published: April 2019

A new visible light communication (VLC) system is proposed for localization in underground mining. Existent systems, such as global positioning system (GPS) and systems based on mobile communication, are generally not useful in underground mining. The proposed system is based on a three-dimensional trilateration VLC localization scheme. This articles offers an evaluation of the proposed system in different evaluation scenarios in terms of the average localization error. The proposed algorithm localizes the source with an average localization estimation error of less than (16.4 cm), based on the source location. The average error is (3.5 cm) for subjects that are very close to the light-emitting-diode (LEDs).The obtained results show the superiority of the proposed method in comparison with traditional short range radio frequency technologies such as RFID, Wi-Fi and Zigbee, making it a feasible system for localizing objects in underground mining.
Precise Identification of Coal Thickness by Channel Wave Based on a Hybrid Algorithm
Authors: Guo Changfang , Yang Zhen , Chang Shuai , Ren Ting , Yao Wenli
Published: April 2019

Precise prediction of coal thickness is of the utmost importance in realizing intelligent and unmanned mining. As the channel wave is characterized by an easily recognizable waveform, a long propagation distance, and strong energy, it is widely used for coal thickness inversion. However, most traditional inversion methods are local in nature, and the inversion result is probably not optimal in the global scope. This paper introduces the GA-SIRT hybrid approach, which combines Genetic Algorithms (GA) and Simultaneous Iterative Reconstructive Techniques (SIRT) in order to deal with the above problem and to improve the accuracy of coal thickness inversion. The proposed model takes full advantage of the strong global search capability of GA and of the fast local convergence rate of the SIRT. Moreover, it inhibits the poor local search ability and the local optimal value effect of the GA and the SIRT respectively. The application of the GA-SIRT in the Guoerzhuang coal mine has significantly enhanced its accuracy, stability, and overall computational efficiency. Hence, the introduced novel hybrid model can precisely resolve and identify the coal thickness according to the channel wave. It can also be extended to other geophysical tomographic inversion problems towards the reduction of potential local optimal solutions.
Fractal Dimension Differentiation between Benign and Malignant Thyroid Nodules from Ultrasonography
Authors: Yan Yu , Zhu Wei , Wu Yi-yun , Zhang Dong
Published: April 2019

Recently, there is increasing interest in identifying benign and malignant nodules by using ultrasound diagnostic technology, which should be helpful to release patients with benign thyroid nodules from suffering unnecessary needle biopsy. In this work, fractal analysis was investigated for the capability of differentiating benign from malignant thyroid nodules during ultrasonography. The B-mode images for 57 patients with suspicious thyroid nodules were captured, followed by ultrasound-guided needle aspiration. The region of interests (ROIs) were subsequently selected from ultrasound images. Then, fractal analysis was performed to extract fractal texture features, and derive the fractal dimension of ROI. The results showed that a significant difference was observed between benign and malignant thyroid nodules (p < 0.05), by comparing this parameter based on independent nonparametric Mann‒Whitney U test. It suggested that fractal dimension is a helpful feature for distinguishing thyroid nodules. In addition, fractal analysis of the B-mode image can provide a reliable reference for tissue typing in ultrasound diagnosis.
Transient Numerical Simulation of Regenerative Systems with Waste Gas Recirculation Strategies in Glass Production Plant
Authors: Cravero Carlo , Spoladore Alessandro
Published: April 2019

The glass production industry has one of the highest energy consumption rates and environmental emission impacts with respect to the existing industrial sectors. Glass furnaces nowadays are conceived with regenerative systems to take advantage of the residual heat from the combustion exhausts in order to increase the thermal efficiency of the system. The exhaust gases are also used in innovative systems to reduce the NOx emissions in specifically designed gas recirculation systems tailored to the glass furnace. In this paper, a numerical model for the simulation of the regenerative chambers in both steady and unsteady conditions is presented. The option of gas recirculation is also included. Special attention has been focused on the radiative heat transfer from the recirculated gases using a gas emissivity model previously developed by the authors.
Superfluids, Fluctuations and Disorder
Authors: Cappellaro Alberto , Salasnich Luca
Published: April 2019

We present a field-theory description of ultracold bosonic atoms in the presence of a disordered external potential. By means of functional integration techniques, we aim to investigate and review the interplay between disordered energy landscapes and fluctuations, both thermal and quantum ones. Within the broken-symmetry phase, up to the Gaussian level of approximation, the disorder contribution crucially modifies both the condensate depletion and the superfluid response. Remarkably, it is found that the ordered (i.e., superfluid) phase can be destroyed also in regimes where the random external potential is suitable for a perturbative analysis. We analyze the simplest case of quenched disorder and then we move to present the implementation of the replica trick for ultracold bosonic systems. In both cases, we discuss strengths and limitations of the reviewed approach, paying specific attention to possible extensions and the most recent experimental outputs.
Measurements and Modelling of Offshore Wind Profiles in a Semi-Enclosed Sea
Authors: Svensson Nina , Arnqvist Johan , Bergström Hans , Rutgersson Anna , Sahlée Erik
Published: April 2019

A conically scanning, continuous-wave LIDAR is placed on an island in the central Baltic Sea with large open-water fetch, providing wind and turbulence profiles up to 300 m height. LIDAR and Weather Research and Forecasting (WRF) profiles from one year are used to characterize the marine boundary layer, at the same time performing an evaluation of the WRF model against LIDAR measurements with a focus on low-level jet representation. A good agreement is found between the average wind speed profile in WRF and LIDAR, with the largest bias occurring during stable conditions. The LLJ frequency is highest in May with frequency of occurrence ranging between 18% and 27% depending on the method of detection. Most of the LLJs occur during nighttime, indicating that most of them do not have local origin. For cases with simultaneous LLJs in both data sets the WRF agrees well with the LIDAR. In many cases, however, the LLJ is misplaced in time or space in the WRF simulations compared to the LIDAR. This shows that models still must be improved to capture mesoscale effects in the coastal zone.
Utilization of Cooking-Type ‘Saba’ Banana in the Development of Ready-to-Drink Juice with Improved Quality and Nutritional Properties
Authors: Robles Maria Kristel T. , Castillo-Israel Katherine Ann T. , Lizardo Rona Camille M.
Published: April 2019

The ‘Saba’ banana cultivar is one of the most abundantly grown fruit crops in the Philippines. However, large postharvest losses were posed due to the rapid deterioration and challenges in marketing. This study was conducted to develop a ready-to-drink (RTD) beverage using the cooking-type banana cultivar [Musa acuminata × balbisiana Colla (ABB Group) ‘Saba’]. The pulp was subjected to treatment with α-amylase and pectinase enzyme concentrations ranging from 0.25% to 1.00% to facilitate juice extraction. The effect of α-amylase and pectinase enzyme combinations on juice yield, color and clarity was determined. The highest juice yield (69.83%) and clarity (72.56% by transmittance at 660 nm) were achieved using 1.00% α-amylase: 1.00% pectinase and 0.5% α-amylase: 1.00% pectinase enzyme treatments, respectively. The juice treated with 0.5% α-amylase: 1.00% pectinase was used in the formulation of the RTD beverage. Physico-chemical and sensory properties of the product were analyzed. The developed RTD ‘Saba’ juice with acceptable sensory characteristics had 11.45 cP viscosity, 0.33% titratable acidity, 5.38% protein, 1660 ppm potassium, 40 ppm sodium and 460 ppm calcium. Results showed that the cooking-type banana cultivar ‘Saba’ can be utilized in the development of the RTD beverage with enhanced sensory and nutritional quality.
Thermal Responsive Performances of a Spanish Balcony-Based Vernacular Envelope
Authors: Foged Isak Worre
Published: April 2019

Many operable and complementary layers make up a vernacular adaptive envelope. With vertical operable translucent textile blinds, horizontal foldable glass doors with thin structural framing, wooden horizontal foldable frames with vertical rotational shutters, plants with dynamic densities, humidity concentrations, and opaque operable textile blinds forming the deep responsive façades of many Southern European buildings as part of the building envelope. This low-tech configuration utilizes behavioral human interaction with the building. On their own, these are singular mechanisms, but as coupled systems, they become highly advanced adaptive building systems used to balance temperature sensations. The research investigates such an adaptive envelope structure through identification of operable elements and their thermal and energy performances through computer simulation models. The designed research computational model includes assessment of heat reception and transfer, resultant operative temperatures, and adaptive comfort sensations. The aim of the research and the material presented in this paper is understanding the performance of native, local, low-tech systems as an opposing approach to contemporary high-tech, complex mechanical systems. The study finds that the operable elements and various compositions make a significant, yet less than anticipated, impact on adaptive thermal comfort temperatures.
Gastric Microbiota in Helicobacter pylori-Negative and -Positive Gastritis Among High Incidence of Gastric Cancer Area
Authors: Gantuya Boldbaatar , El-Serag Hashem B. , Matsumoto Takashi , Ajami Nadim J. , Oyuntsetseg Khasag , Azzaya Dashdorj , Uchida Tomohisa , Yamaoka Yoshio
Published: April 2019

Helicobacter pylori (H. pylori) related chronic gastritis is a well-known major etiological factor for gastric cancer development. However, H. pylori-negative gastritis (HpN) is not well described. We aimed to examine gastric mucosal microbiota in HpN compared to H. pylori-positive gastritis (HpP) and H. pylori-negative non-gastritis group (control). Here, we studied 11 subjects with HpN, 40 with HpP and 24 controls. We performed endoscopy with six gastric biopsies. Comparison groups were defined based on strict histological criteria for the disease and H. pylori diagnosis. We used 16S rRNA gene amplicon sequencing to profile the gastric microbiota according to comparison groups. These results demonstrate that the HpP group had significantly lower bacterial richness by the operational taxonomic unit (OTU) counts, and Shannon and Simpson indices as compared to HpN or controls. The linear discriminant analysis effect size analysis showed the enrichment of Firmicutes, Fusobacteria, Bacteroidetes and Actinobacteria at phylum level in the HpN group. In the age-adjusted multivariate analysis, Streptococcus sp. and Haemophilus parainfluenzae were at a significantly increased risk for HpN (odds ratio 18.9 and 12.3, respectively) based on abundance. Treponema sp. was uniquely found in HpN based on occurrence. In this paper, we conclude that Streptococcus sp., Haemophilus parainfluenzae and Treponema sp. are candidate pathogenic bacterial species for HpN. These results if confirmed may have important clinical implications.
Plant Virus-Like Particle In Situ Vaccine for Intracranial Glioma Immunotherapy
Authors: Kerstetter-Fogle Amber , Shukla Sourabh , Wang Chao , Beiss Veronique , Harris Peggy L. R. , Sloan Andrew E. , Steinmetz Nicole F.
Published: April 2019

Despite aggressive multi-modality treatment with surgery, radiation and chemotherapies, malignant glioma inevitably recurs and has dismal survival rates. Recent progress in immunotherapy has led to a resurgence of interest, and immunotherapies are being investigated for treatment of glioma. However, the unique brain anatomy and a highly immunosuppressive glioma microenvironment pose significant challenges to achieving efficacy. Thus, there is a critical need for assessment of next-generation immunotherapies for glioma. In this study, we have investigated the efficacy of the nanoparticle platform technology based on plant-derived Cowpea mosaic virus like particles (empty CPMV or eCPMV) to instigate a potent immune response against intracranial glioma. CPMV immunotherapy has been shown to efficiently reverse the immunosuppressive tumor microenvironments in pre-clinical murine models of dermal melanoma and metastatic melanoma, metastatic breast cancer, intraperitoneal ovarian cancer and in canine patients with oral melanoma. In the present study, we demonstrate that in situ administration of CPMV immunotherapy in the setting of glioma can effectively recruit unique subset of effector innate and adaptive immune cells to the brain parenchyma while reducing immune suppressive cellular population, leading to regression of intracranial glioma. The in situ CPMV nanoparticle vaccine offers a potent yet safe and localized immunotherapy for intracranial glioma.