bluuebunny/crossref_metadata_2025 huggingface dataset:
Further experiments and remarks regarding the possible formation of blood stains on the Turin Shroud: stains attributed to the nailing of the hands
Authors: Heger Anna , König Lisa , Reckert Alexandra , Schröder Melanie , Kiliç Ferhat , Emami Farahs , Ritz-Timme Stefanie
Published: February 2024

The formation of red discolorations (‘blood stains’) on the Turin Shroud (TS), a Christian relic believed to be the burial cloth of Jesus of Nazareth, is controversially discussed. We performed experiments to identify possible explanations for the formation of the stains on the hands and forearms of the Turin Shroud Man (TSM). In preliminary non-standardised experiments, after applying blood to the dorsal and palmar side of the probands’ wrists, they moved their arms around at their own discretion to provoke blood flows as similar as possible to those on the TS. A blood stain pattern similar to that on the left wrist could be provoked by slowly turning the wrist to the ulnar side. In contrast, a branched pattern of multiple streaks, as depicted on the forearms, was difficult to reproduce. In a standardised test setup, the probands moved their dry, dirtied, or oiled arms jerkily in a predetermined sequence of movements. More body hair only slightly facilitated the formation of a branched pattern. On oiled skin, however, the formation of branches was significantly facilitated. This may support the hypothesis that the blood stains on the forearms were formed by moving the body between the unnailing and the burial. The formation of a branched pattern seems feasible if the arms were moved jerkily and were possibly exposed to water and oils postmortem (e.g. transporting the washed and oiled body). Nevertheless, the well-defined blood stains with multiple branchings are difficult to explain. Additionally, the blood stains on the forearms may have originated from deep scourging wounds, where dried blood was again mobilised by water (and oil). We are aware that no reliable conclusions about the formation of the ‘blood stains’ on the TS can be drawn from our findings. However, they may contribute to the discussion on this topic.
Impact of a short-term nitrate and citrulline co-supplementation on sport performance in elite rowers: a randomized, double-blind, placebo-controlled crossover trial
Authors: Viribay Aitor , Alcantara Juan M. A. , López Iker , Mielgo-Ayuso Juan , Castañeda-Babarro Arkaitz
Published: February 2024

Purpose

Citrulline (CIT) and beetroot extract (BR) have separately shown benefits in rowing performance-related outcomes. However, effects of combined supplementation remain to be elucidated. The main purpose of this research was to study the effects of 1 week of daily co-supplementation of 3.5 g BR (500 mg NO3−) plus 6 g CIT on aerobic performance, maximal strength, and high-intensity power and peak stroke in elite male rowers compared to a placebo and to a BR supplementation.

Methods

20 elite rowers participated in this randomized, double-blind, placebo-controlled crossover trial completing 1 week of supplementation in each group of study: Placebo group (PLAG); BR group (BRG); and BR + CIT group (BR-CITG). 3 main physical tests were performed: aerobic performance, Wingate test and CMJ jump, and metabolic biomarkers and physiological outcomes were collected.

Results

The Wingate all-out test showed no between-condition differences in peak power, mean power, relative power, or fatigue index (P > 0.05), but clearance of lactate was better in BR-CITG (P < 0.05). In the performance test, peak power differed only between PLAG and BR-CITG (P = 0.036), while VO2peak and maximum heart rate remained similar. CMJ jumping test results showed no between-condition differences, and blood samples were consistent (P > 0.200).

Conclusion

Supplementation with 3.5 g of BR extract plus 6 g of CIT for 7 days improved lactate clearance after Wingate test and peak power in a performance test. No further improvements were found, suggesting longer period of supplementation might be needed to show greater benefits.
Tattooing to reconstruct Nipple-Areola Complex after oncological breast surgery: a scoping review
Authors: Maselli Deborah , Torreggiani Martina , Livieri Tiziana , Farioli Gloria , Lucchi Stefania , Guberti Monica
Published: February 2024

Purpose

The dermopigmentation of the Nipple-Areola Complex (NAC) is a safe non-surgical reconstruction technique that can restore psychophysical integrity, representing the final step after oncological surgery. This scoping review aims to identify and synthesize the literature focused on medical tattooing for NAC reconstruction in women who underwent breast reconstruction after cancer surgery. Competence and training, outcomes and organizational aspects were assessed as specific outcomes.

Methods

The Joanna Briggs Institute (JBI) methodology for scoping reviews was followed. MEDLINE, Embase, Cochrane Library, Clinical Key, Scopus and Cinahl databases were consulted. After title (N = 54) and abstract (N = 39) screening and full-text review (N = 18), articles that met eligibility criteria were analyzed, critically apprised and narratively synthesized.

Results

13 articles were analysed, with full texts (N = 11) and only abstract (N = 2). The overall quality of the literature (N observational studies = 11; N pilot experimental studies = 2) is weak. Nurses were the professionals mostly involved (N = 6), then medical staff (N = 4) and tattoo artists (N = 2). The professional training is poorly described in 6 papers. The most frequently assessed outcome was the satisfaction rate (N = 8). One study explored aspects of quality of life with a validated questionnaire. The management of these services resulted variable. Nurse-led services were implemented in 2 studies.

Conclusion

Despite methodological weaknesses, NAC tattooing research is relevant because it helps women redefine their identity after demolitive cancer treatments. Further research on processes and outcomes is needed.
Assessment of Direct Tensile Strength Tests in Rock Through a Multi-laboratory Benchmark Experiment
Authors: Pérez-Rey Ignacio , Muñiz-Menéndez Mauro , Frühwirt Thomas , Konietzky Heinz , Jacobsson Lars , Perras Matthew A. , Atefi-Monfared Kamelia , Mas Ivars Diego , Sánchez Juncal Abel , Alejano Leandro R.
Published: February 2024

This study aims to experimentally assess repeatability and reproducibility of direct tensile strength (DTS) tests with deformability measurements on two types of rocks: Blanco Mera granite (Spain) and Cotta sandstone (Germany). The tests were conducted in four rock mechanics laboratories located in different countries (Canada, Germany, Spain and Sweden). A total of 51 tests were performed on cylindrical specimens of the two rocks, using different test equipment and measuring devices. Mean and standard deviation DTS values were determined in the four laboratories for the granite (5.70 ± 0.32, 6.06 ± 0.11, 3.84 ± 0.50 and 6.76 ± 0.10 MPa) and for the sandstone (1.88 ± 0.07, 1.96 ± 0.06, 1.15 ± 0.32 and 1.74 ± 0.19 MPa), together with Young’s moduli and Poisson’s ratios in tension, being statistically analysed to evaluate the variability and compare the main results obtained from the participating laboratories. The findings indicate that the DTS test with deformability measurements on cylindrical rock specimens is operationally feasible. However, certain shortcomings have been identified during the course of the experiments with the existing methodologies, such as the one suggested by the ISRM for DTS tests. The results have also shown to be sensitive to appropriate test and strain measurement configurations. The objective of this study was to shed light on these issues and provide new insights for potential future improvements of the existing testing methods.
Navigated bedside implantation of external ventricular drains with mobile health guidance: technical note and case series
Authors: Sargut Tarik Alp , Thomale Ulrich-Wilhelm , Schulz Matthias , Schaumann Andreas , Schneider Ulf Christoph , Bayerl Simon Heinrich , Spindler Philipp , Vajkoczy Peter , Ferdowssian Kiarash
Published: February 2024

Purpose

External ventricular drain (EVD) implantation is one of the fundamental procedures of emergency neurosurgery usually performed freehand at bedside or in the operating room using anatomical landmarks. However, this technique is frequently associated with malpositioning leading to complications or dysfunction. Here, we describe a novel navigated bedside EVD insertion technique, which is evaluated in a clinical case series with the aim of safety, accuracy, and efficiency in neurosurgical emergency settings.

Methods

From 2021 to 2022, a mobile health–assisted navigation instrument (Thomale Guide, Christoph Miethke, Potsdam, Germany) was used alongside a battery-powered single-use drill (Phasor Health, Houston, USA) for bedside EVD placement in representative neurosurgical pathologies in emergency situations requiring ventricular cerebrospinal fluid (CSF) relief and intracranial pressure (ICP) monitoring.

Results

In all 12 patients (8 female and 4 male), navigated bedside EVDs were placed around the foramen of Monro at the first ventriculostomy attempt. The most frequent indication was aneurysmal subarachnoid hemorrhage. Mean operating time was 25.8 ± 15.0 min. None of the EVDs had to be revised due to malpositioning or dysfunction. Two EVDs were converted into a ventriculoperitoneal shunt. Drainage volume was 41.3 ± 37.1 ml per day in mean. Mean length of stay of an EVD was 6.25 ± 2.8 days. Complications included one postoperative subdural hematoma and cerebrospinal fluid infection, respectively.

Conclusion

Combining a mobile health–assisted navigation instrument with a battery-powered drill and an appropriate ventricular catheter may enable and enhance safety, accuracy, and efficiency in bedside EVD implantation in various pathologies of emergency neurosurgery without adding relevant efforts.
Assessment of language lateralization in epilepsy patients using the super-selective Wada test
Authors: Kakinuma Kazuo , Osawa Shin-ichiro , Katsuse Kazuto , Hosokawa Hiroaki , Ukishiro Kazushi , Jin Kazutaka , Niizuma Kuniyasu , Tominaga Teiji , Endo Hidenori , Nakasato Nobukazu , Suzuki Kyoko
Published: February 2024

Background

The classical Wada test (cWada), performed by injecting a short-acting anesthetic through the intracarotid route, helps determine language dominance. In the cWada, adverse effects are observed in 10–30% of trials, hindering accurate assessments. In this study, we assessed the effectiveness of the super-selective Wada test (ssWada), a more selective approach for anesthetic infusion into the middle cerebral artery (MCA).

Methods

We retrospectively examined the data of 17 patients with epilepsy who underwent ssWada via anesthetic injection into one M1 segment of the MCA and at least one contralateral trial.

Results

The ssWada identified 12 patients with left language dominance, 3 with right language dominance, and 2 with bilateral language distribution. Nine trials on the language dominant side resulted in global aphasia for patients with left- or right language dominance. Of the 13 trials conducted on the non-dominant language side, 12 revealed intact language function and one resulted in confusion. Among these, the outcomes of global aphasia or no language impairment were confirmed in the contralateral trials. Among the 22 trials of unilateral M1 injections in patients with unilateral language dominance, 21 (95.5%) showed either global aphasia or no language impairment, indicating language dominance.

Conclusions

The ssWada yields clear results, with a high rate of over 90% in determining the language dominant hemisphere with few side effects.
Hirayama’s disease associated with cervical deformity and spinal cord compression: a case report from Sweden
Authors: Wänman Johan , Persson Per Anders , Bobinski Lukas
Published: February 2024

Background

Hirayama’s disease (HD) is most common in young males, and previous studies are predominantly from Asian countries. The cause of HD is unknown but the most common theory about the pathology speculates on forward bending that causes a compression of the dura mater and the anterior horn of the spinal cord against the vertebra during an overstretch flexion that may result in myelopathy. Both anterior and posterior cervical surgical approaches have been shown to be effective in stopping the disease and improving function; however, HD is also reported to be a self-limited disease, and treatment with a cervical collar may be an alternative for these patients.

Case report

We report HD in a 17-year-old male from Sweden who underwent surgical treatment with a 2 level anterior cervical discectomy and fusion (ACDF) due to neurological progression from HD after conservative treatment.

Conclusion

HD is rare and is easily overlooked. Surgical intervention shows promising results for neurological progression, but HD is also reported to be a self-limited disease.
An agro-meteorological hazard analysis for risk management in a Mediterranean area: a case study in Southern Italy (Campania Region)
Authors: Alilla Roberta , Capitanio Fabian , De Natale Flora , Parisse Barbara , Pontrandolfi Antonella
Published: February 2024

Agriculture is highly dependent on environmental, climate and weather conditions and on extreme weather events leading to natural disasters. Such events are more and more frequent in Italy, and in the last decades huge public investments were dedicated to risk management policies in agriculture. In order to set an adequate weather-related risk assessment, a robust analysis of the hazard is needed, which requires an agro-meteorological approach to detect the potential impacts of weather extremes on agricultural activities. With the aim of assessing the effectiveness of the current risk management policy in catching the main hazards, specific agro-meteorological indices were applied to highlight occurrence, trends, and spatial patterns of extreme events. The analysis was based on reanalysis datasets and focused on a study area in Southern Italy (Campania region) during the 1981–2021 period. The findings are reported in terms of maps and statistics aggregated at administrative unit level (5 provinces) and show a general intensification of weather extremes in the last decades, both in frequency and intensity of the events. The main indications refer to growth rates of heavy precipitation, potentially leading to flood, locally exceeding 3–4 mm/year, an increasing number of months with severe/extreme droughts, mainly concentrated during the growing season. An upward trend was also observed for days with extreme maximum temperatures, which already exceeded or approached 50% between June and September in the 1981–2021 period in most areas. Maximum temperatures above 35 °C are becoming more frequent and in the inner areas they were reached in 10 days in the 2021 summer quarter. On the other hand, no significant trends were detected for late frosts. In terms of policy implications, the results seem to suggest that some extreme weather events can no longer be considered as exceptional at the present time and in a trend perspective, making them less suitable to be addressed through the risk management tools based almost exclusively on the strategy of transferring risks (insurances and more recent mutual funds) both for farmers and for the allocation of public resources. Therefore, the need is underlined for improving the design of the risk management policies to increase farms’ resilience and adaptation to climate change. Moreover, the study highlights the information potential of agro-meteorological indices in supporting evidence-based decision making in agriculture.
Intersubunit communication in glycogen phosphorylase influences substrate recognition at the catalytic sites
Authors: Kamada Nahori , Ikeda Ayato , Makino Yasushi , Matsubara Hiroshi
Published: February 2024

Glycogen phosphorylase (GP) is biologically active as a dimer of identical subunits, each activated by phosphorylation of the serine-14 residue. GP exists in three interconvertible forms, namely GPa (di-phosphorylated form), GPab (mono-phosphorylated form), and GPb (non-phosphorylated form); however, information on GPab remains scarce. Given the prevailing view that the two GP subunits collaboratively determine their catalytic characteristics, it is essential to conduct GPab characterization to gain a comprehensive understanding of glycogenolysis regulation. Thus, in the present study, we prepared rabbit muscle GPab from GPb, using phosphorylase kinase as the catalyst, and identified it using a nonradioactive phosphate-affinity gel electrophoresis method. Compared with the half-half GPa/GPb mixture, the as-prepared GPab showed a unique AMP-binding affinity. To further investigate the intersubunit communication in GP, its catalytic site was probed using pyridylaminated-maltohexaose (a maltooligosaccharide-based substrate comprising the essential dextrin structure for GP; abbreviated as PA-0) and a series of specifically modified PA-0 derivatives (substrate analogs lacking part of the essential dextrin structure). By comparing the initial reaction rates toward the PA-0 derivative (Vderivative) and PA-0 (VPA-0), we demonstrated that the Vderivative/VPA-0 ratio for GPab was significantly different from that for the half-half GPa/GPb mixture. This result indicates that the interaction between the two GP subunits significantly influences substrate recognition at the catalytic sites, thereby providing GPab its unique substrate recognition profile.
A fair procedure in a marriage market
Authors: Kuvalekar Aditya , Romero-Medina Antonio
Published: February 2024

We propose a new algorithm in the two-sided marriage market wherein both sides of the market propose in each round. The algorithm always yields a stable matching. Moreover, the outcome is a Rawlsian stable matching if the number of men and women is equal. Lastly, the algorithm can be computed in polynomial time and, from a practical standpoint, can be used in markets where fairness considerations are important.
A comprehensive systematic review and meta-analysis study in comparing decompressive craniectomy versus craniotomy in patients with acute subdural hematoma
Authors: Habibi Mohammad Amin , Kobets Andrew J. , Boskabadi Amir Reza , Mousavi Nasab Mehdi , Sobhanian Pooria , Saber Hamishegi Fatemeh , Naseri Alavi Seyed Ahmad
Published: February 2024

There are two controversial surgery methods which are traditionally used: craniotomy and decompressive craniectomy. The aim of this study was to evaluate the efficacy and complications of DC versus craniotomy for surgical management in patients with acute subdural hemorrhage (SDH) following traumatic brain injury (TBI). We conducted a comprehensive search on PubMed, Scopus, Web of Science, and Embase up to July 30, 2023, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Relevant articles were reviewed, with a focus on studies comparing decompressive craniectomy to craniotomy techniques in patients with SDH following TBI. Ten studies in 2401 patients were reviewed. A total of 1170 patients had a craniotomy, and 1231 had decompressive craniectomy. The mortality rate was not significantly different between the two groups (OR: 0.46 [95% CI: 0.42–0.5] P-value: 0.07). The rate of revision surgery was insignificantly different between the two groups (OR: 0.59 [95% CI: 0.49–0.69] P-value: 0.08). No significant difference was found between craniotomy and decompressive craniectomy regarding unilateral mydriasis (OR: 0.46 [95% CI: 0.35–0.57] P-value < 0.001). However, the craniotomy group had significantly lower rates of non-pupil reactivity (OR: 0.27 [95% CI: 0.17–0.41] P-value < 0.001) and bilateral mydriasis (OR: 0.59 [95% CI: 0.5–0.66] P-value: 0.04). There was also no significant difference in extracranial injury between the two groups, although the odds ratio of significant extracranial injury was lower in the craniotomy group (OR: 0.58 [95% CI: 0.45–0.7] P-value: 0.22). Our findings showed that non-pupil and bilateral-pupil reactivity were significantly more present in decompressive craniectomy. However, there was no significant difference between the two groups regarding mortality rate, extracranial injury, revision surgery, and one-pupil reactivity.
Design and rationale for an open-label, randomized, controlled pilot trial to evaluate the changes in blood uremic toxins in patients with chronic kidney disease by dietary therapy with sake lees
Authors: Tokumaru Toshiaki , Toyama Tadashi , Nakade Yusuke , Ogura Hisayuki , Oshima Megumi , Nakagawa Shiori , Furuichi Motoe , Kitajima Shinji , Sakai Norihiko , Shimizu Miho , Iwata Yasunori , Wada Takashi
Published: February 2024

Background

Patients with chronic kidney disease (CKD) reportedly show dysbiosis, which is the imbalance of gut microbiome. Dysbiosis increases the uremic toxin level in the intestine, and uremic toxins transfer into the blood, causing CKD progression. Sake lees, a traditional Japanese fermented food, may help reduce uremic toxins by altering the gut microbiome. Additionally, D-alanine, which is present in sake lees, may have a renoprotective effect. The present pilot study aims to evaluate the effect of adding sake lees to the standard CKD dietary therapy in reducing blood uremic toxins.

Methods

This pilot study is a single-center, open-label, randomized controlled trial. Twenty-four patients with CKD will be enrolled and allocated 1:1 to the intervention and control groups. The intervention group will receive standard CKD dietary therapy with an additional intake of 50 g of sake lees per day for 8 weeks, whereas the control group will only receive standard CKD dietary therapy. The primary endpoint is the change in serum indoxyl sulfate after 8 weeks. The secondary endpoint is the plasma D-alanine and fecal microbiome changes.

Conclusion

This pilot study provides insight into the development of a new diet focused on gut microbiome and D-amino acids in patients with CKD.

Clinical trial registration

This protocol was approved by the Clinical Trial Review Board of Kanazawa University Hospital on October 27, 2022 (2022-001 [6139]) and available to the public on the website of the Japan Registry of Clinical Trials on November 22, 2022 (jRCT1040220095).
Upward-directed exit-site of the swan-neck catheter and “Easy-to-disinfect the backside area of exit-site” may prevent PD complications
Authors: Ogawa Kyohei , Ikeda Masato , Shirai Izumi , Ohshiro Kentaro , Maruyama Yukio , Yokoo Takashi , Tanno Yudo , Terawaki Hiroyuki , Sakurada Tsutomu , Yoshikawa Kazuhiro , Inoue Hironobu , Higuchi Chieko , Kaneko Tomohiro , Nogaki Fumiaki , Ueda Atsushi , Maeda Yoshitaka
Published: February 2024

Background

Upward-directed exit-site has been believed to be the worst for frequent ESI by an old retrospective study using straight catheters. No comparison study of 3 exit-site directions using swan-neck catheter has been performed regarding which direction is the best for our endpoints, Easy-to-see the backside area of exit-site: ESBE, Easy-to-disinfect the backside area of exit-site: EDBE, reduction of both exit-site infection (ESI), symptomatic catheter dislocation and peritonitis.

Methods

We assessed the relationship of exit-site direction with our endpoints in a quantitative cross-sectional, multicentered questionnaire survey. Patients who received either non-surgical catheter implantation or exit-site surgery were excluded.

Results

The numbers (percentage) of exit-site directions in included 291 patients were upward 79 (26.0), lateralward 108 (37.5) and downward 105 (36.5). Cochran-Armitage analysis showed a significant step-ladder increase in the prevalence of ESI as the direction changed from upward to lateralward to downward (0.15 ± 0.41, 0.25 ± 0.54, 0.38 ± 0.69 episodes/patient-year, p = 0.03). Multivariable regression analysis revealed the upward exit-site independently associates with both higher frequency of ESBE (OR 5.55, 95% CI 2.23–16.45, p < 0.01) and reduction of prevalence of ESI (OR 0.55, 95%CI 0.27–0.98, p = 0.04). Positive association between the prevalence of symptomatic catheter dislocation and ESI (OR 2.84, 95% CI 1.27–7.82, p = 0.01), and inverse association between EDBE and either prevalence of symptomatic catheter dislocation (OR 0.27, 95% CI 0.11–0.72) or peritonitis (OR 0.48, 95% CI 0.23–0.99) observed.

Conclusion

Upward-directed swan-neck catheter exit-site may be the best for both ESBE and prevention of ESI. EDBE may reduce catheter dislocation and peritonitis. Symptomatic catheter dislocation may predict ESI.
Slope of the estimated glomerular filtration rate and its associated factors among individuals with chronic kidney disease in the general Japanese population
Authors: Ito Jun , Fukagawa Masafumi
Published: February 2024

Background

To suppress the incidence of end-stage kidney disease, we need to identify chronic kidney disease (CKD) patients with a high risk of rapid decline in the estimated glomerular filtration rate (eGFR). However, the current status of eGFR slope and its associated factors in the Japanese population have not been fully elucidated.

Methods

Among examinees aged 40–70 years in the 2014 Specific Health Checkup conducted by the National Health Insurance in Kobe, Japan (n = 61,985), we prospectively observed 7291 examinees with CKD stage G3 from 2014 to 2018.

Results

Until 2018, 4221 examinees continued to undergo annual SHCs for a total of five checkups per subject and had available records of all necessary data. The median eGFR change was −0.22 ml/min/1.73 m2/year. Only 9.2% of those subjects showed rapid eGFR decline (faster than −2.0 ml/min/1.73 m2/year). Logistic regression analysis identified diabetes, smoking habits, high urinary protein levels, older age, high systolic blood pressure, and low serum low-density lipoprotein cholesterol levels as independent predictors for rapid eGFR decline. Hemoglobin A1c levels did not contribute to the eGFR slope in CKD stage-G3 subjects with diabetes and proteinuria.

Conclusion

Most Japanese CKD stage-G3 subjects had a very slow decline in eGFR. A small proportion of CKD individuals who have a predictive factor of rapid eGFR decline should receive considerable attention from a nephrologist.
Analogical proportions in monounary algebras
Authors: Antić Christian
Published: February 2024

This paper studies analogical proportions in monounary algebras consisting only of a universe and a single unary function, where we analyze the role of congruences, and we show that the analogical proportion relation is characterized in the infinite monounary algebra formed by the natural numbers together with the successor function via difference proportions.
Religion in Family Firms: A Socioemotional Wealth Perspective on Top-Level Executives with Perceived Religiosity
Authors: Ernst Fabian , Bendig David , Puechel Lea
Published: February 2024

The extent and mechanisms through which religion intertwines with decision-making processes in family firms remain inadequately understood. Family firm owners, driven by their commitment to ethical business practices and the safeguarding of their socioemotional wealth, actively seek cues to inform their decision-making processes. This research demonstrates that, among these guiding cues, top-level executives’ perceived religiosity emerges as a relevant factor. Building upon the socioemotional wealth perspective and conducting a longitudinal analysis based on listed family firms between 2009 and 2018, our findings reveal a positive association between family voting rights and the presence of board members perceived to be religious. Furthermore, this relationship is less pronounced if family firms operate in industries with high research and development intensity. Our study confirms that boards with high shares of religiously perceived directors are positively associated with the appointment of chief executive officers perceived to be religious during succession events. We thereby present a unique perspective that acknowledges perceived religiosity as a micro-level constituent shaping board membership and successor selection. This investigation captures the intricate interplay between religion and family firms under a socioemotional wealth umbrella, offering important insights to the family business ethics discourse. Our research also offers practical implications for board and leadership diversity management in family firms.
Characterizing Measurement-Based Care in the Texas Youth Depression and Suicide Research Network (TX-YDSRN)
Authors: Slater Holli , AlZubi Yasmin , Rezaeizadeh Afsaneh , Hughes Jennifer L. , Gorman April , Mayes Taryn L. , Elmore Joshua S. , Storch Eric A. , Wakefield Sarah M. , Trivedi Madhukar H.
Published: February 2024

Integration of measurement-based care (MBC) into clinical practice has shown promise in improving treatment outcomes for depression. Yet, without a gold standard measure of MBC, assessing fidelity to the MBC model across various clinical settings is difficult. A central goal of the Texas Youth Depression and Suicide Research Network (TX-YDSRN) was to characterize MBC across the state of Texas through the development of a standardized tool to assess the use of MBC strategies when assessing depression, anxiety, side effects, and treatment adherence. A chart review of clinical visits indicated standardized depression measures (71.2%) and anxiety measures (64%) were being utilized across sites. The use of standardized measures to assess medication adherence and side effects was limited to less than six percent for both, with the majority utilizing clinical interviews to assess adherence and side effects; yet medication was changed in nearly half. Rates of utilization of standardized measures for participants with multiple MBC forms were similar to those who only provided one form.
Severe convective storms’ reproduction: empirical analysis from the marked self-exciting point processes point of view
Authors: Lo Galbo Giada , Chiodi Marcello
Published: February 2024

The paper focuses on the evaluation of hailstorms’ and thunderstorms winds’ events in the United States of America, in the period from 1996 to 2022, under the marked spatio-temporal self-exciting point processes point of view. The aim of the present article is the assessment and description of the spatio-temporal spontaneous and reproducing activity of severe hailstorms’ and thunderstorms winds’ processes. The present application shows how the spatio-temporal pattern is well-fitted and clearly explainable, according to the flexible semi-parametric ETAS model fitting.
Queer students in international higher education: a review of distinct motivations, considerations, and challenges
Authors: Campbell Anne C. , Dezago Jordyn , Townsend Quintessence
Published: February 2024

Pursuing education overseas is a high impact practice in higher education. Students who identify as LGBTQIA + —commonly referred to as “queer,” an umbrella term—may be more likely to participate yet face additional unique challenges. Using a systematic review of literature across multiple disciplines, this paper explores LGBTQIA + students’ motivations, identity development, and university experiences while participating in education overseas. It also aims to define the term queer international student and examines the theoretical frames used to understand this population in the literature. Findings show that literature carves out a composite of students who view, and sometimes actively seek, overseas education to develop themselves, express their identities, and live in communities that are more welcoming and safer than those at home. However, they also face conflict in English language classrooms, on campuses, and with their families as they navigate expectations, with some switching between cisheteronormative and queer identities in different communities. On university campuses, scholars noted, queer international students can be viewed singularly as international students, with their sexual orientations and other intersectional identities going unrecognized or being erased. Moreover, higher education scholars and practitioners often do not designate—or perhaps exclude—international students in studies and programming for LGBTQIA + students. As a result, queer international students may not feel like they belong in any group and risk being double-marginalized in higher education. This paper concludes with five recommendations for additional research in this emerging subfield of higher education literature.
Refractive outcomes of small lenticule extraction (SMILE) Pro® with a 2 MHz femtosecond laser
Authors: Saad Amr , Klabe Karsten , Kirca Mücella , Kretz Florian A. T. , Auffarth Gerd , Breyer Detlev R. H.
Published: February 2024

Purpose

To evaluate the initial visual outcomes of Small Incision Lenticule Extraction (SMILE) Pro® using a 2 MHz femtosecond laser (VisuMax 800, Carl Zeiss Meditec) and to assess the efficacy, safety, predictability, accuracy, and complication rate.

Methods

This retrospective analysis included eyes which underwent the SMILE Pro® procedure using VisuMax 800 femtosecond laser to correct myopia. All surgeries were performed by one surgeon (DB). Follow-up was conducted 3 months postoperatively to evaluate visual outcomes after neuroadaptation, corrected visual acuity (CDVA) and intra- and postoperative complications.

Results

One hundred and fifty-two eyes of 82 patients (mean age 31 ± 6 years) results at 3 months are presented. The mean spherical equivalent (SE) was − 4.44 ± 1.86 D preoperatively while -0.24 ± 0.32 D postoperatively. 99% of eyes achieved SE within ± 1.0 D of attempted correction and 91% were within ± 0.5 D. Efficacy index was 0.93 while the safety index was 1. No complications occurred intra- or postoperatively. No eyes lost more than 1 line of their preoperative CDVA. All highly myopic eyes (− 6.25 to − 10.00 D; n = 18) achieved 20/20 at 3 months postoperatively and were within 0.5 D from the attempted SE and no eyes lost more than 1 line of CDVA.

Conclusion

The SMILE Pro® is a safe, efficient, and predictable procedure for the treatment of myopia and myopic astigmatism, with comparable results of conventional SMILE surgery. High myopic eyes achieve better results than low and moderate myopia. No complications were recorded in our patients.
The application of high-throughput sequencing technology in corneal diseases
Authors: Zhao Jing yi , He Yu xi , Wu Mei liang , Wang Rui qing
Published: February 2024

High-throughput sequencing technology, also known as next-generation sequencing technology, can explore new biomarkers and specific gene mutations. It has a pivotal role in promoting the gene research, which can limit the detection area, lessen the time needed for sequencing. Also, it can quickly screen out the suspected pathogenic genes of patients, gain the necessary genetic data, and provide the basis for clinical diagnosis and genetic counseling. In the research of corneal diseases, through the DNA sequencing of patients’ diseased cells, it can provide a deeper understanding of corneal diseases and improve the diagnosis, classification and treatment alternatives of various corneal diseases. This article will introduce the application progress of high-throughput sequencing technology in corneal diseases, which will help to understand the application of this technology in various corneal diseases.
Ethical Challenges in Mariculture: Adopting a Feminist Blue Humanities Approach
Authors: Peterson Jesse D.
Published: February 2024

As mariculture—the cultivation of aquatic organisms in marine environment—intensifies to meet the demands of sustainable blue growth and national policies, novel ethical challenges will arise. In the context of ethics, primary concerns over aquaculture and mariculture tend to stay within differing value-based perspectives focused on benefits to human and non-human subjects, specifically animal welfare and animal rights. Nonetheless, the burgeoning field of feminist blue humanities provides ethical considerations that extend beyond animal subjects (including humans), often because of its concerns with new materialist, posthumanist, and other relations-based theories. This article examines feminist blue humanities and the contributions it may bring to understanding contemporary and future ethical challenges posed by mariculture and its intensification, especially the cultivation of low-trophic organisms. By offering an overview of feminist blue humanities, this article explores some of its particularities by drawing out three major ethical concerns facing contemporary mariculture, specifically material reconfigurations, radical alteration of the lives of low-trophic species through industrialization and increases in maricultural waste products.
‘It’s so Beneficial to be Able to Stop the Cycle’: Perceptions of Intergenerational Transmission of Violence and Parenting Practices Among Pregnant Women and their Abusive Partners
Authors: Taccini Federica , Domoney Jill , Ocloo Josephine , Heslin Margaret , Byford Sarah , Bick Debra , Howard Louise M , MacMillan Harriet , Mannarini Stefania , Ramchandani Paul , Stanley Nicky , Trevillion Kylee
Published: February 2024

Purpose

This study aimed to explore how pregnant women who experience Domestic Violence and Abuse (DVA) and men who commit DVA understand the impact of their childhood environment on their relationships with their children and co-parents, and how a DVA psychological intervention may shape their parenting.

Methods

Repeated individual qualitative interviews were conducted with pregnant mothers and fathers who reported DVA and were taking part in a psychological intervention to address DVA. Interviews were carried out at the start (during pregnancy) and end of the intervention (two years post-childbirth). Reflexive Thematic Analysis was used to analyse interviews.

Results

56 interviews (26 mothers; 13 fathers) were analysed. Five themes were identified: (1) Acknowledging childhood experiences of DVA; (2) The scars of traumatic experiences; (3) Challenging the silencing of abuse; (4) The transmission of parenting styles and behaviours from one generation to another; (5) Becoming the best parent one can be. The intergenerational transmission of violence was identifiable in most narratives. Despite this, several participants described skills they acquired during the intervention (e.g., emotional regulation strategies) as assisting in interrupting violence and improving their relationships with their children.

Conclusions

Participants who acknowledged having encountered childhood abuse recognised it as one of several risk factors for DVA in adulthood. They also discussed the potential for trauma-informed interventions to address the intergenerational transmission of violence and poor parenting practices.
An Entropy Stable Discontinuous Galerkin Method for the Two-Layer Shallow Water Equations on Curvilinear Meshes
Authors: Ersing Patrick , Winters Andrew R.
Published: February 2024

We present an entropy stable nodal discontinuous Galerkin spectral element method (DGSEM) for the two-layer shallow water equations on two dimensional curvilinear meshes. We mimic the continuous entropy analysis on the semi-discrete level with the DGSEM constructed on Legendre–Gauss–Lobatto (LGL) nodes. The use of LGL nodes endows the collocated nodal DGSEM with the summation-by-parts property that is key in the discrete analysis. The approximation exploits an equivalent flux differencing formulation for the volume contributions, which generate an entropy conservative split-form of the governing equations. A specific combination of a numerical surface flux and discretization of the nonconservative terms is then applied to obtain a high-order path-conservative scheme that is entropy conservative. Furthermore, we find that this combination yields an analogous discretization for the pressure and nonconservative terms such that the numerical method is well-balanced for discontinuous bathymetry on curvilinear domains. Dissipation is added at the interfaces to create an entropy stable approximation that satisfies the second law of thermodynamics in the discrete case, while maintaining the well-balanced property. We conclude with verification of the theoretical findings through numerical tests and demonstrate results about convergence, entropy stability and well-balancedness of the scheme.
Well-Posedness for Mean Field Games with Finite State and Action Space
Authors: Liu Lu-ping , Jia Wen-sheng
Published: February 2024

The main purpose of this paper is to investigate the well-posedness for mean field game with finite state and action space (FSASMFG) by using nonlinear analysis methods. First, we set up the bounded rationality model of the FSASMFG in the topological space. Next, we study some sufficient conditions of generalized strong well-posedness (GS-wp) and strong well-posedness (S-wp) for a class of FSASMFGs. Finally, we give some characterizations of GS-wp and S-wp for FSASMFGs with the help of set-valued analysis methods. These new results presented in the paper develop and improve the corresponding conclusions in the recent literature.
Research on Solving Flexible Job Shop Scheduling Problem Based on Improved GWO Algorithm SS-GWO
Authors: Zhou Kai , Tan Chuanhe , Zhao Yi , Yu Junyuan , Zhang Zhilong , Wu Yanqiang
Published: February 2024

As an important branch of production scheduling, the flexible job shop scheduling problem (FJSP) is a typical NP-hard problem. Researchers have adopted many intelligent algorithms to solve the FJSP problem, nonetheless, the task of dynamically adapting its essential parameters during the computational process is a significant challenge, resulting in the solution efficiency and quality failing to meet the production requirements. To this end, this paper proposes an adaptive gray wolf fast optimization algorithm (SS-GWO), which adopts the gray wolf algorithm (GWO) as the basic optimization method, and the algorithm adaptively selects the global search or local search according to the degree of agglomeration of individuals. Firstly, a non-linear convergence factor strategy is employed to control the global exploration and local exploitation capabilities of the algorithm at different stages. This enhances optimization precision and accelerates convergence speed, achieving a dynamic balance between the two. Secondly, the spiral search mechanism of Whale Optimization Algorithm is used in GWO to improve the exploration capability of Gray Wolf Optimization Algorithm. Finally, the effectiveness of SS-GWO model is verified by comparison experiments. The comparison demonstrates the superiority of SS-GWO over the other five state-of-the-art algorithms in solving the 22 classical benchmark test functions. SS-GWO is applied to solve FJSP by means of the standard test function bandimarte calculus. The optimal solution and performance of SS-GWO for solving FJSP are compared with other algorithms. The experimental results show that the SS-GWO algorithm has good optimization performance, and the maximum completion time is reduced by 19% and 37% compared with that of IGWO and GWO, respectively, and the proposed SS-GWO algorithm achieves a better solution effect on flexible job shop scheduling instances, which can satisfy the actual production scheduling needs.
Soil water availability modulates the response of grapevine leaf gas exchange and PSII traits to a simulated heat wave
Authors: Shtai W. , Asensio D. , Kadison A. E. , Schwarz M. , Raifer B. , Andreotti C. , Hammerle A. , Zanotelli D. , Haas F. , Niedrist G. , Wohlfahrt G. , Tagliavini M.
Published: February 2024

Background and aims

A better understanding of plant carbon assimilation, water status and photosystem performance responses to combined heat and drought stress would help to optimize grapevine management under such limiting conditions.

Methods

Gas exchange and chlorophyll fluorescence parameters were measured in potted grapevines, cv Sauvignon Blanc, before, during and after simulated six-day heat (Tmax = 40 °C) wave using heated well-watered (HW), heated drought-stressed (HD), non-heated well-watered (CW) and non-heated dry (CD) vines.

Results

Photosynthesis and stomatal conductance in HW vines increased during the morning and dropped in the afternoon with respect to CW vines. Daily plant transpiration in HW almost doubled that of CW vines. When grapevines were already exposed to drought, the effects of the heat wave were negligible, with HD plants showing similar leaf photosynthesis and transpiration to their CD counterparts. Heat, but not drought stress, decreased the maximum (Fv/Fm) and effective photochemical quantum yield of PSII (φPSII), and also affected the use of absorbed energy. HW plants dissipated more radiative energy as heat, a protective mechanism of the photosystem, while HD vines increased the energy dissipated by non-regulated non-photochemical pathways, which might lead to photoinhibition damages. The different behavior could be due to the enhanced transpiration rate and consequent decrease in leaf temperature in HW as compared to HD vines. After the heat wave, only HW vines recovered the afternoon values of photosynthesis, stomatal conductance and φPSII to similar levels as those in CW vines.

Conclusion

Drought had a more significant effect than heat stress on photosynthesis, stomatal conductance and transpiration. The combined heat and drought stress, however, increased the proportion of energy lost by the leaves through harmful non-regulated dissipative pathways. With adequate soil water availability, grapevines withstood the heat wave period through an increase in leaf transpiration, which decreased leaf temperature and protected the PSII from heat damage.
A biomedical perspective of pyocyanin from Pseudomonas aeruginosa: its applications and challenges
Authors: Mudaliar Samriti Balaji , Bharath Prasad Alevoor Srinivas
Published: February 2024

Pyocyanin is a bioactive pigment produced by Pseudomonas aeruginosa. It is an important virulence factor that plays a critical role in P. aeruginosa infections as a redox-active secondary metabolite and a quorum sensing (QS) signaling molecule. Pyocyanin production from chorismic acid requires the involvement of two homologous operons, phz1 and phz2, which are activated by QS regulatory proteins. Pyocyanin inhibits the proliferation of bacterial, fungal, and mammalian cells by inducing oxidative stress due to which it acts as a potent antibacterial, antifungal, and anticancer agent. Its potential role as a neuroprotectant needs further exploration. However, pyocyanin exacerbates the damaging effects of nosocomial infections caused by P. aeruginosa in immunocompromised individuals. Further, cystic fibrosis (CF) patients are highly susceptible to persistent P. aeruginosa infections in the respiratory system. The bacterial cells form colonies and three interconnected QS networks—pqs, las, and rhl—get activated, thus stimulating the cells to produce pyocyanin which exacerbates pulmonary complications. As an opportunistic pathogen, P. aeruginosa produces pyocyanin to impede the recovery of injuries like burn wounds through its anti-proliferative activity. Moreover, pyocyanin plays a vital role in compounding P. aeruginosa infections by promoting biofilm formation. This review begins with a brief description of the characteristics of pyocyanin, its activity, and the different aspects of its production including its biosynthesis, the role of QS, and the effect of environmental factors. It then goes on to explore the potential applications of pyocyanin as a biotherapeutic molecule while also highlighting the biomedical challenges and limitations that it presents.

Graphical abstract