bluuebunny/crossref_metadata_2025 huggingface dataset:
Health System Preparedness for a Potential Third Wave of COVID-19
Authors: Bobhate Prateek S. , Shrivastava Saurabh R.
Published: May 2023

The second wave of COVID-19 pandemic has overwhelmed the health system across India leading to not only the loss of innumerable human lives but also exposed the various shortcomings of healthcare infrastructure. This emphasizes the need for a better preparedness of the health system across the nation to tackle the potential third wave of COVID-19 pandemic more importantly now as the cases and test positivity rate has started to show a downward trend all over India. The key areas which need to be targeted are augmenting the vaccine production and streamlining delivery mechanism, strengthening the existing pediatric emergency units and sick newborn units, expanding the oxygen production capacity in the country, ensuring the availability of drugs, strengthening of health infrastructure, logistic support and surveillance systems, expanding the free testing and diagnostic facilities, improved access to healthcare facilities, and reinforcement of COVID appropriate behavior in the community.
Clinicopathological Analysis of Fungal Lesions with Unique Presentations in Immunocompetent Adults – A Case Series from a Tertiary Care Hospital in North Karnataka
Authors: Masgal Meenakshi , Patil Anuradha G. , Sutradhar Debarghya , Mahanta Anita A.
Published: May 2023

Introduction:

Fungal infections are mostly an opportunistic infection in immunocompromised patients and posttraumatic in immunocompetent adults. However, there has been a recent increasing trend of cases among immunocompetent adults with no history of trauma. Very few case series describing the clinicopathological picture of prevalent fungi are available from the various regions of India.

Aims and Objectives:

The present study aims to analyze clinicopathological features of various cases of fungal etiology with unique or rare presentations.

Materials and Methods:

This study included a clinicopathological analysis of surgical specimens received for histopathological examination at our hospital with special emphasis on cases with rare or unique presentations during the 1-year period from June 2019 to June 2020.

Results:

A total of 11 cases of fungal lesions with rare or unique clinicopathological presentations were selected for analysis. Majority of the patients were male, and most of them were from a rural background. There were four cases of aspergillosis, two cases of fungal keratitis, one case of renal aspergillosis, and one case of a subcutaneous swelling with discharging sinus. There were three cases of chromoblastomycosis, which presented as subcutaneous swellings with no lesion of overlying skin. There was an incidental finding of Candida sp. in two esophageal endoscopic biopsies, which primarily revealed esophageal adenocarcinoma. There was one case each of eumycetoma and mucormycosis. However, the mucormycosis case occurred in the setting of fungal abscess with osteomyelitis of the left mandible.

Conclusion:

Fungal lesions have revealed an increasing trend of infections in immunocompetent individuals in recent years, with various unique clinicopathological presentations. Therefore, there is a need for increased vigilance and analysis of such cases.
Awareness, Attitude, and Practice About Basic Life Support Among Dental Students
Authors: Bansal Savita , Gupta Jigyasa , Singhla Juhi , Harit Kadambari , Ragesvari Kajasai , Jain Manya
Published: May 2023

Introduction:

A medical emergency can be described as a sudden onset of serious illness or injury requiring immediate medical attention otherwise it can put a patient's health in serious jeopardy, often referred to as a situation risking “life or limb.” It is thus imperative that dental students are competent enough to administer basic life support (BLS) to manage emergencies which can occur anywhere and anytime.

Materials and Methods:

A cross-sectional survey was conducted to assess the knowledge, attitude, and perception among dental students of Manav Rachna Dental College, Faridabad, about BLS. A total of 177 students participated in the study. The respondents were provided with a prevalidated, self-administered questionnaire which comprised 23 closed-ended questions about knowledge, three questions about attitude, and five questions about practice of BLS. The questionnaire was administered in an online mode using Google Forms.

Results:

The results showed that majority of students lacked adequate knowledge about BLS protocol. The average score of 177 respondents was 7.8/23 points which is significantly low.

Discussion:

Life-threatening medical emergencies can occur at any time. There have been reports of Cardiopulmonary Arrest (CPA) and deaths in dental clinics. Therefore, it is crucial for dental practitioners to have adequate knowledge about BLS or CAB consisting of (C) circulation, (B) breathing, and (A) airway opening.

Conclusion:

The dental students lack adequate knowledge to perform BLS procedures with ease and confidence. However, they had a positive attitude toward it.
Automated Complete Blood Count Profile as a Probable Indicator of Dengue Fever Severity in Children
Authors: Majumdar Arijit , Kumar Abhisek , Biswas Soumali
Published: May 2023

Background:

Dengue is now endemic in more than 100 tropical and subtropical countries. Ninety percent of dengue hemorrhagic fever occurs in children <15 years of age. Leukopenia and thrombocytopenia near the end of the febrile phase are the common findings in dengue fever.

Aims and Objectives:

(1) To see any significant correlations between various hematological parameters with severity of dengue and (2) to see the shift in the values (increase/decrease) of platelet indices in dengue patients.

Materials and Methods:

One hundred and twenty patients admitted either with laboratory report of seropositive dengue or with dengue-like symptoms and who were found to be dengue positive after admission were included in the study. Complete hemogram including platelet indices was evaluated by an automated cell counter. Clinical examinations were performed in detail with special reference to the presence of warning signs such as vomiting, lethargy, pain abdomen, bleeding, and ascites.

Results:

Total leukocyte count, platelet distribution width, and mean platelet volume were not significantly different in patients with warning signs from those without it. The level of mean hematocrit was significantly higher and the mean plateletcrit was significantly lower in dengue with warning signs.

Conclusions:

Simultaneous measurement of complete blood count and platelet indices can provide us a valid instrument for the measurement of dengue disease severity and an insight into the potential etiology that resulted in change in platelet indices.
A Case Report – Synchronous Endometrial and Ovarian Cancer
Authors: Metgud Mrityunjay , Srivani Tella , Patil Kamal Prakash , Savanur Mahadevi , Malli Rajashekhar , Sanikop Adarsh , Bhise Rohan
Published: May 2023

Synchronous malignancies of the female genital tract are a very rare entities. Synchronous endometrial and ovarian cancer (SEOC's) is defined as simultaneous presence of these two cancers at the time of diagnosis as opposed to the metachronous cancer where these two cancers are diagnosed at different chronologic time points. Clinical presentation of these women is indistinct, and due to the different management and the favorable prognosis of SEOC's, an extensive pathological evaluation is required to distinguish SEOC's from the metastatic disease. Synchronous and Metachronous malignant tumours are the two components of multiple primary malignant tumours (MPMT's). The distinction between the independent primary tumors and metastatic tumours is clinically significant and complicated. Synchronous endometrial and ovarian carcinoma is a rare entity. SEOC's are more frequently undiagnosed. Henceforth, the diagnostic dilemma of SEOC's versus metastatic disease is challenging and therefore separating the two groups is important as the prognosis is different.
Obesity and its Impact on the Different Aspects of the COVID-19 Infection
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: May 2023

The coronavirus disease-2019 (COVID-19) pandemic continues to impact the lives of everyone and has influenced the functioning of all the sectors. In general, obesity tends to alter most of the physiological processes in the human body, including the immune system. Thus, it is important to get insights about the effect of obesity on the course of infection, so that morbidity and mortality can be minimized. An extensive search of all materials related to the topic was carried out in the PubMed search engine and World Health Organization website, and a total of 16 articles were selected based on the suitability with the current review objectives. Keywords used in the search include COVID-19 and obesity. It has been reported that obesity plays an important role in different aspects of the infection (viz., increased risk to acquire the infection or more chances to transmit the infection), management, and the worst clinical outcome. To conclude, obesity has to be acknowledged as one of the risk factors for compromising the pulmonary functions and thus should be considered as a high-risk group. In fact, as obesity is an independent risk factor to warrant hospitalization of the COVID-19 patients, it is essential that the medical team anticipates the challenges and manages the obese patients proactively and improves their clinical outcomes.
Effects of Muscle Energy Technique and Proprioceptive Neuromuscular Facilitation Stretch Technique on Hamstring Muscle Flexibility in Recreational Athletes
Authors: Dinesh D. , Sudhakar S.
Published: May 2023

Introduction:

The most common muscle injury in sports is the hamstring muscle. It needs long rehabilitation and has a great possibility of recurrence as it has a great tendency to shorten. Stretching is the treatment used to improve muscular flexibility, thereby increasing range of motion, and the study prevents sports injuries and athletic performance.

Aim of Study:

The aim of this study is to compare the efficacy of muscle energy technique (MET) and proprioceptive neuromuscular facilitation (PNF) stretch technique on the flexibility of the hamstring among recreational athletes.

Materials and Methods:

Thirty healthy recreational athletes were divided into two groups MET and PNF for 4 weeks – 5 sessions/week.

Outcome Measures:

The Modified Back Saver's Sit and Reach Test was the outcome measure.

Statistical Tool:

The Student t-test was used for statistical analysis.

Conclusion:

There was a significant difference seen in the PNF stretch technique and hamstring flexibility with the use of the MET.
Epidemiological Aspects of Preinvasive Cervical Lesions and the Role of p16INK4a Immunohistochemistry in Their Diagnosis
Authors: Ogbu Christian C , Ndukwe Chinedu O , Chiemeka Michael E , Madubuike Kingsley C , Ukah Cornelius O
Published: May 2023

Introduction:

There is a high burden of cervical cancer in our environment. Most patients present late when the prognosis is guarded. Hence, accurate diagnosis of preinvasive lesions from cervical biopsies is important for clinical decision and patient management. Therefore, the use of immunohistochemistry in most difficult cases is paramount and justifies the study. The aim of the study is to evaluate the expression and diagnostic role of p16INK4a Immunohistochemistry in preinvasive cervical lesions.

Materials and Methods:

The paraffin blocks of all histologically diagnosed preinvasive and normal/reactive lesions of the cervix seen in two histopathology laboratories in Nnewi: Nnamdi Azikiwe University Teaching Hospital and Pathocon Specialist Clinic and Research Institute over a 10-year retrospective period (2011–2020) were retrieved from the archives. Fresh h and e slides were produced and reviewed for diagnostic consistency and a consensus diagnosis rendered for each case. The cases were subjected to immunohistochemistry using p16INK4a monoclonal antibodies.

Results:

A total of 402 cervical biopsies were seen in the records of both facilities. Ninety of them were noninvasive lesions (62 preinvasive lesions and 28 normal/reactive lesions). Thus, the prevalence of preinvasive lesions in this study was 15.4% (62/402). However, 51 cases met our inclusion criteria. The consensus H and E diagnosis consists of 15 normal/reactive, 12 low squamous intraepithelial lesion (LSIL), and 24 hIL. The diagnosis using immunohistochemistry consisted of 23 normal/reactive (45.1%), 6 LSIL (11.8%), and 22 hIL (43.1%). The age range of the patients was 34–80 years. The mean and median ages were 49.7 and 47 years respectively. The peak ages for LSIL and high squamous intraepithelial lesion (HSIL) were 41–60 years and 51–60 years, respectively. Only 21.5% (ca in situ-3.9% and squamous intraepithelial lesion-17.6) of the patients were biopsied on account of preinvasive cervical lesions. The sensitivity and specificity of p16INK4a in the diagnosis of HSIL were 75% and 85%, respectively. There was a significant statistical difference between the diagnosis before and after the application of p16INK4a (P < 0.001).

Conclusion:

There is a high prevalence of preinvasive lesions in our environment. Majority of the preinvasive lesions were incidental findings. Immunohistochemistry using p16INK4a is a very useful adjunct to H and E for diagnosing preinvasive cervical lesions, especially in challenging cases.
Correlation between Transverse Abdominis Muscle Endurance and Body Mass Index Among College Students
Authors: Patel Gayatri H , Chitte Sonali J , Bhagat Camy Anilkumar , Bhura Paras Abhesinh
Published: May 2023

Introduction:

From among the core muscles (local and global), transversus abdominis muscle (TrA) is controlled independently as compared to the other trunk muscles. It creates a belt around the abdomen. “Abdominal draw-in” of the abdomen creates isolated activation of the TrA. Body mass index (BMI) is a measure of body fat based on height and weight. Low endurance of inner core muscles is one of the risk factors for mechanical low back pain. Studies say that high BMI is a risk factor for low back pain. This study aims to assess the TrA muscle endurance and BMI to determine the correlation between the two parameters.

Purpose:

The objective of the study is to find the correlation between BMI and transverse abdominis endurance among KPGU Physiotherapy College students.

Materials and Methods:

In this correlation study, 30 college students were selected by convenience sampling method on the basis of inclusion and exclusion criteria. BMI of all participants was calculated. Transverse abdominis muscle endurance was assessed using pressure biofeedback/sphygmomanometer.

Results:

Results showed a significant negative correlation between TrA endurance and BMI (Pearson's correlation test; r = −0.45 at P < 0.05).

Conclusion:

The study concluded that students with higher BMI have low TrA endurance.
Afatinib-induced acneiform eruptions
Authors: Thakur Twinkle Singh , Agrawal Shreya , Madke Bhushan , Jawade Sugat , Padmawar Gauri , Verma Khushboo
Published: May 2023

Epidermal growth factor receptor (EGFR) inhibitors are being increasingly used in the treatment of non-small cell carcinoma of the lung. Cutaneous toxicity of various EGFR inhibitors is being increasingly noticed by dermatologists. We hereby report a case of papulopustular eruption in a male patient who had received oral afatinib for well-differentiated squamous cell carcinoma of the lower lip. The offending drug was continued and the papulopustular eruption was treated with oral doxycycline and local care.
Association of D-Dimer and Lipid Biomarkers with Preeclampsia and Their Role in Prediction from a Rural Tertiary Care Setting
Authors: Jhansi K , Harsoda J M
Published: May 2023

Background:

Preeclampsia affects 5%–7% of all pregnancies globally and is the leading cause of maternal and fetal death and morbidity. The mechanisms responsible for the pathogenesis of preeclampsia are unclear. Preeclampsia is characterized as hypertension with or without proteinuria after the 20th week of pregnancy and is associated with endothelial dysfunction, systemic vasoconstriction, inflammation, oxidative stress, and intrauterine growth restriction, and multiorgan dysfunction.

Materials and Methods:

A total of 120 women were divided into two groups: 60 women without PE (control group) and 60 women with PE in a prospective observational case–control study conducted in a rural tertiary care setting in India. This study was done from January 2019 to December 2019, after approval from the local ethical committee. Women with singleton pregnancy either primiparous or multiparous, aged between18 and 40 years were included in both case and control groups.

Results:

The participants in this study ranged in age from 18 to 38 years old, with an average age of 26.38 ± 4.38 years. The average age of the women in the case group was 26.42 + 3.92 years, while the average age of the women in the control group was 27.38 ± 4.52 years. Most of the patients were between the ages of 31 and 40 (51.67%) years. The mean gestational age in the case group was 26.60 ± 2.19 weeks, while it was 26.73 ± 2.39 weeks in the control group.

Conclusion:

Early screening of pregnant women for high D-dimer levels and lipid profile can play a significant role in reducing the morbidity and mortality of both mother and fetus.
Severe Eczematous Dermatitis with Hyperimmunoglobulin E Syndrome
Authors: Ramapure Raavi , Pugalia Nidhi , Ganjre Samyak , Singh Adarshlata , Madke Bhushan
Published: May 2023

Primary immunodeficiency syndrome represents a heterogeneous group of inherited disorders caused by mutations in genes encoding functional proteins of the immune cells and characterized by an increased risk of infections, autoimmunity, autoinflammation, malignancy, and allergic disorders. Hereby, we report an 8-year-old-male child with complaints of severe itchy lesions over the body since infancy. Thorough investigations showed he had primary immunodeficiency with underlying hyperimmunoglobulin E syndrome.
Prioritizing Training of Undergraduate Medical Students in Mental Health Competencies
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: May 2023

Mental health has been acknowledged an integral component of maintenance of optimal health of individuals and communities. The purpose of the current review was to explore the teaching practices for mental health competencies and strengthen the same in undergraduate teaching period. An extensive search of all materials related to the topic was carried out in the PubMed search engine and a total of 19 articles were selected based on their suitability with the current review objectives. Amid the shortage of trained psychiatrists, it becomes an indispensable need that undergraduate medical students are trained in specific competencies in the subject so that they are empowered to manage basic psychiatric illnesses, especially at the primary level of health care. If we can train our medical undergraduate students, it will turn out to be the most cost-effective and feasible approach to meet the needs of the rural and remote sections of the society. As the imparted mental health training is grossly inadequate or incomplete, it is a must that we take specific steps to improve the existing scenario. In conclusion, psychiatry is an essential and integral component of medical training in the undergraduation period. However, the subject lacks the desired attention under the present circumstances, and thus there is an indispensable need to improve the training and assessment of psychiatric competencies so that students become competent in discharging their future clinical roles.
Facial Nerve Palsy in Parotid Infection- A Benign Deviance From the malignant Norm
Authors: Pattanshetti Vishwanath M , Teli Basavaraj , Sharma Prashant , Gupta Urbee , Kolli Pravallika , Bhagwan Adil Anwar
Published: May 2023

Parotid swellings presenting with facial nerve palsy usually imply that the swelling is malignant in nature. In rare cases, it has been reported to have occurred in the setting of benign parotid swellings and parotid abscesses. Our case is one of bilateral parotid abscesses in a reverse transcription polymerase chain reaction negative, CORADS five patients, with left-sided lower motor neuron type of facial nerve palsy with near-total recovery of the facial nerve palsy after resolution of abscess. The likely mechanisms behind the development of facial nerve palsy in case of parotid abscess include perineuritis, ischemia, and direct virulence of the pathogen. Furthermore, coronavirus has a propensity for affecting salivary glands, and parotitis could be an atypical presentation of the COVID 19. In most cases, as in ours, there has been improvement of facial nerve palsy with resolution of the abscess after combined conservative, surgical, and supportive treatment.
Internet Addiction and Its Impact on Mental Health among Dental Students, Belagavi
Authors: Bhattarai Shubhechchha , Angolkar Mubashir , Chate S. S. , Dhagavkar Pooja S.
Published: May 2023

Background:

Internet dependence ordinarily alludes to a person's powerlessness to control their utilization of the Internet (counting any online-related, impulsive, or compulsive conduct), which finally leads to one's stamped trouble and practical debilitation in everyday life. The signs and indications of Internet Addiction Disorder can be seen in both physical and psychological (emotional) appearances. Few psychological symptoms include: Sadness, nervousness, disconnection, sensation of blame, mindset swings, depression, dread, and so forth.

Objective:

To assess the prevalence of Internet addiction and its impact on mental health among dental students of Belagavi city.

Materials and Methods:

A cross-sectional study was conducted, involving 168 dental students of age 17-25 years of Belagavi city. Students were selected using convenient sampling method and data were collected using pretested structured questionnaire. The ethical clearance was obtained from the institutional ethics committee JNMC Belagavi. Written consent was obtained from participants before collecting data which was analyzed in SPSS version 22.

Results:

The percentage of the normal use of Internet and potential addiction of Internet was 83.3% and 16.7%, respectively. Internet addiction was not associated with depression. But was significantly associated with anxiety, stress, and insomnia.

Conclusion:

The prevalence of potential Internet addiction among dental students is 16.7%. Hence, it becomes necessary to not only address the Internet addiction among dental students but also the mental issues related to it.
Association of SNP rs163550 in IL5RA Gene with Risk of Preeclampsia
Authors: Sivaraj Nagarjuna , Rachel K Vijaya , Suvvari Tarun Kumar , Prasad Shilaja , Boppana Sriharsha , Naidu Vineetha , Vegi Pradeep Kumar , Aboufandi Youssef , Simhachalam Kutikuppala L V
Published: May 2023

Background:

Several research have looked at the significance of SNPs in inflammatory mediator genes and their link to preeclamptic pregnancies, but the results have not been conclusive enough to explain why SNPs in inflammatory mediator genes may increase the risk of preeclampsia. The goal of this study is to analyze the IL5RA SNPs in order to learn more about the possible link between preeclampsia and inflammatory genes.

Materials and Methods:

A total of 304 pregnant participants were a part of this prospective observational case-control study, out of which 152 had preeclampsia, and the other 152 participants had normotensive pregnancies. The “polymerase chain reaction-restriction fragment length polymorphism” method was used to genotype SNP rs163550.

Results:

The commonness of the IL5RA rs163550G allele has been linked to an increased risk for preeclampsia with P value: 0.0230 and odds ratio: 0.6818 (95% confidence interval: 0.489–0.9505).

Conclusion:

A prominent association among the IL5RA rs163550 SNP and preeclampsia in comparison to nonpreeclampsia has been observed in the study. The study stands first to report IL5RA Polymorphism association with the pathogenesis of preeclampsia's among the Indian population.
Role of Proprioceptive Neuromuscular Facilitation Exercises in Post-COVID Individuals
Authors: Gohil Divya , Shaji Merin , Baxi Gaurang , Palekar Tushar J.
Published: May 2023

Background:

Pulmonary function, fatigue, and chest mobility are three important parameters which are impaired after COVID-19. Manual stretching procedures have the potential to improve pulmonary function, reduce fatigue, and improve chest mobility. However, evidence regarding their effectiveness in post-COVID-19 population remains unknown. This study explores the effectiveness of two different types of stretching techniques on pulmonary function, fatigue, and chest expansion in post-COVID-19 population.

Materials and Methodology:

Forty post-COVID-19 patients with mild and moderate impairment were divided into two groups (20 each). Group A received hold relax proprioceptive neuromuscular facilitation (PNF) pectoral stretching while Group B received chest mobility exercises for 20 min each for 7 sessions. The outcomes measures were pulmonary function test, fatigue, and chest expansion.

Results:

Significant within-group differences for all outcome measures were seen at the end of intervention. Between-group analysis showed a significant statistical difference in few parameters of pulmonary function testing and chest expansion in Group A than Group B. However, no statistical significance on Fatigue after the 7 sessions of intervention.

Conclusions:

In COVID-19 survivors with mild and moderate impairment, hold relax PNF stretching than chest mobility exercises has a significant effect on improving pulmonary function, reducing fatigue, and improving chest expansion.
Comparative Study of Automated versus Manual Measurement of Body Temperature
Authors: Pandarbale Sanjay Shamrao , Sardessai Sandip R. , Rodrigues Edelweiss
Published: May 2023

Background:

Evaluation of body temperature is one of the important diagnostic methods and signs of health and disease, both in everyday life and medical care. Study of Automated versus Manual Measurement of Body Temperature: a comparative study. It is one of the frequently performed clinical observations.

Materials and Methods:

We took 148 apparently healthy medical students in the age group of 18–23 years (n = 90 females, n = 58 males). Their oral and axillary temperatures were recorded using mercury and digital thermometers. Data were collected and analyzed using Student's “t”–test, and P < 0.05 was taken as scientifically significant.

Results:

In our study, we found that the difference in the temperatures between mercury and digital thermometers is so negligible that it will not cause any problems in the clinical interpretation.

Conclusion:

Hence, we would like to recommend the use of digital thermometer to that of mercury thermometer because it is very simple, easy, accurate, and convenient to use.
Bibliometric Study of Placenta in Pregnancy-Induced Hypertension
Authors: Alam Mohammed Shaiqul , Islam Md. Monirul
Published: May 2023

Background:

The placenta is a responsible organ for nourishing and protecting the fetus during pregnancy. It is a key limb for pregnancy evolution and fetal expansion that acts on maternal-fetal exchanges of gas and nutrients.

Materials and Methods:

This bibliometric analysis investigated the publications that were produced from 1977 to 2021 and indexed in PubMed database. The database was inspected for all documents related to placenta in pregnancy. About 298 documents were found and examined in database. The VOSviewer software was used to imagine the co-occurrence arrangement.

Results:

The analysis found the greatest publications resulted out from the “USA” (n = 282), “China” (n = 185), and “Australia” (n = 153). In addition, the results found that most of the publications are journal article (n = 222). “Pregnancy Hypertension” supplied the majority of documents. Almost all documents were produced in the last decade (2011–2021). The study found the most relevant affiliations where University of Melbourne ranked first (n = 80), King's College London ranked second (n = 54), and University of Mississippi Medical Center ranked third (n = 50). The study found Hannan NJ (n = 10, TC = 1.22) as the most productive author in the field. The co-occurrence scrutiny confirmed that the study formed five clusters. The study found that “pregnancy,” “female,” “human,” “pre-eclampsia,” and “adult” are the most useful keywords on the topic.

Conclusion:

Assessment of placenta is an enormously important interpreter, which helps to progress the result of pregnancy. This bibliometric study illustrates the overall research scenery, trends, growth, impact, and collaborative work among scholars in the field of placenta in pregnancy-induced hypertension.
Primary pulmonary adenoid cystic carcinoma- clinicopathological features and predictors of poor outcome
Authors: Aiman Aiffa , Zahir Zafirah , Makhdoomi Rumana , Farooq Roudah Binti , Jeelani Tazeen
Published: May 2023

Introduction:

Primary pulmonary adenoid cystic carcinoma is a rare disease. Its clinico-pathological features, course of disease, therapeutic strategy, and survival data have not been fully elucidated. We aimed to study the clinicopathological characteristics of primary pulmonary adenoid cystic carcinomas in north India.

Methods:

This study was a retrospective, single-centre, cohort study. The database of the hospital was searched for a period of seven years to identify all patients with primary pulmonary adenoid cystic carcinoma.

Results:

Out of 6050 lung tumors, 10 were primary adenoid cystic carcinomas. The mean age of diagnosis was 42 (±12) years. Six patients had the lesion in the trachea, main bronchus or truncus intermedius and four had parenchymal lesions. Seven patients had resectable tumours. Three patients achieved an R0 resection, two achieved R1 resection and two had R2 resection. On histopathological examination, almost all of the patients had cribriform pattern. Only four patients (57.1%) showed positivity for TTF-1 staining. The five-year survival of patients with resectable tumour and un-resectable tumour was 85.7% and 33.3%, respectively (P = 0.01). The predictors of poor outcome included non-operability of the tumour, presence of metastasis at the time of diagnosis, and macroscopically positive tumour margin during surgery.

Conclusion:

Primary pulmonary adenoid cystic carcinoma is a unique and rare tumour that affects relatively younger individuals, males and females, as well as smokers and non-smokers equally. The features of bronchial obstruction are the most common. Surgery is the primary modality of treatment and completely resectable lesions have the best prognosis.
Out of the box diagnosis in a child treated as childhood interstitial lung disease- William-Campbell syndrome
Authors: Madhusudan Manoj , Chandra Tejaswi , Mohite Kaustubh M. , Srikanta JT
Published: May 2023

A 9-year-old school-going boy was referred to us for evaluation of childhood interstitial lung disease (chILD), with complaints of persisting dry cough, since the newborn period, tachypnea at rest, and failure to gain weight. Upon evaluation his findings were consistent with William-Campbell syndrome (WCS). He was advised for airway clearance technique (ACT) and was started on Bipap at night for splinting of the airways.
Deep Belief Neural Network Based Automatic CVD Prediction Using Adaptive Sliding Window Technique
Authors: Sambhaji Patil Sachin , B. Mohite-Patil Tanaji
Published: May 2023

INTRODUCTION: Cardiac Vascular Disease (CVD) is determined to be the most prevailing disease all over the globe specifically in the case of elderly persons. Among various cardiac disease, CVD account for major mortality all over the globe. Diagnosis of cardiac disease at an early stage is mandatory to reduce the rate of mortality. Still, there is no availability of skilled specialists even in case of developed countries for accurate diagnosis.
OBJECTIVES: Achieving automated and accurate diagnosis, computer vision based methods that functions with the help of AI techniques are focused on by researchers. In this current research automated CVD prediction model is designed using a deep learning approach.
METHODS: ECG image dataset is utilized in this proposed CVD prediction model. Initially, the Non-ST-elevation myocardial infarction (NSTEMI) ECG data collected from the healthcare centre is taken as input. This input ECG image is converted into a signal and further, it is segmented using the sliding window segmentation technique. Then, using segmented signal QRS peak detection is achieved using Elephant Herd Optimization (EHO) algorithm. From the peak, detected signal features are extracted using Heart Rate Variability (HRV) analysis. Following that the extracted features are sent as input into the Deep Belief Network (DBN) classifier to predict CVD patients. 
RESULTS: The proposed CVD prediction model is implemented and some of the performance metrics are calculated. Accuracy, error, precision, sensitivity and specificity attained by the proposed model using the second dataset are 95%, 5%. 96%, 94% and 96%. Results showed that the functioning of proposed CVD prediction model is better when compared with other existing techniques.
CONCLUSION: Based on this analysis it can be revealed that accurate and timely CVD prediction can be achieved with a lessor error rate. Further, this proposed model can be used in real time healthcare application by collecting NSTEMI ECG signal from patients.
Chern–Simons functional, singular instantons, and the four-dimensional clasp number
Authors: Daemi Aliakbar , Scaduto Christopher
Published: May 2023

Kronheimer and Mrowka asked whether the difference between the four-dimensional clasp number and the slice genus can be arbitrarily large. This question is answered affirmatively by studying a knot invariant derived from equivariant singular instanton theory, and which is closely related to the Chern–Simons functional. This also answers a conjecture of Livingston about slicing numbers. Also studied is the singular instanton Frøyshov invariant of a knot. If defined with integer coefficients, this gives a lower bound for the unoriented slice genus, and is computed for quasialternating and torus knots. In contrast, for certain other coefficient rings, the invariant is identified with a multiple of the knot signature. This result is used to address a conjecture by Poudel and Saveliev about traceless

SU(2)

representations of torus knots. Further, for a concordance between knots with non-zero signature, it is shown that there is a traceless representation of the concordance complement which restricts to non-trivial representations of the knot groups. Finally, some evidence towards an extension of the slice-ribbon conjecture to torus knots is provided.
Personal Reflections on the Experience of Migration to the UK Post 2004 by Women from Poland.
Authors:   , Fiebig Lord Sabina
Published: May 2023

This thesis examines subjective experiences of Polish women migrants in the UK. Since the Accession 8 (A8) of the European Union in 2004 the United Kingdom has experienced one of the largest migration movements from the new member states. Post 2004 the UK has been a common destination for Polish migrants. Currently Polish women migrants in the UK outnumber their male counterparts. Substantial scholarship on the Polish A8 migration to the UK has been undertaken, nonetheless personal experiences of Polish women migrants are still in need of further research. The aim of this thesis is to fill this gap and offer new insights on everyday lived experiences of migration through the eyes of the migrant herself. Combining autoethnography, life story interviews conducted with different generational cohorts of Polish women and fictional texts on mobility as well as secondary data, this thesis explores the complexities of everyday experience of migration in relation to migrants’ social identities, gender, notions of home and belonging as well as legacies of the post-socialist past. Migrant stories in this thesis are linked with experiences and meanings of migration, but also migrants’ feelings and imaginations, opinions, views, and memories. The thesis purposes a multi-layered, polyvocal and complex reflection on subjective experiences of migration. Thus, offers an account of everyday migration experiences which is personal, local and political therefore aware of both discourse and larger socio-cultural and geopolitical panorama, whilst highlighting its dynamic, fluid and complex character.
A desistência de tornar-se professor(a) de matemática: questões simbólicas, sociais, culturais e econômicas
Authors: Barbosa Fernandes Luzia de Fatima , De Paula e Silva Priscila Adriana
Published: May 2023

Este trabalho teve como objetivo investigar os motivos que levaram os estudantes do curso deLicenciatura em Matemática de uma Universidade Federal Mineira a abandonar a presente graduação.Metodologicamente, esta pesquisa é de natureza qualitativa, configurada na análise do materialempírico que foi obtido por meio de questionário e de entrevista. O público para a pesquisa foram osdiscentes que desistiram do curso no período de 2009 até 2020. Analiticamente, utilizamos asocioanálise de Pierre Bourdieu, a fim de compreender os fatores simbólicos, sociais, culturais eeconômicos que levaram esses discentes a desistirem do curso, considerando, por exemplo, a trajetóriaescolar de cada um deles. A partir da análise sociológica realizada, observamos que os resultadosapontam para a desistência do ensino superior, especificamente o curso de Licenciatura, como umproblema de origem social imbricado por fatores simbólicos.
Harmful Algal Bloom Toxin Microcystin-LR Induces Macrophage Inflammation of Lung Tissues
Authors: Patel Shivani C
Published: May 2023

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Paraoxanase 1 Deletion Leads to Increased Cardiac Remodeling and Cardiac Fibrosis in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease
Authors: Soehnlen Sophia
Published: May 2023

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Lactated Ringer's Vs Normal Saline for Acute Pancreatitis:
Authors: Aziz Muhammad
Published: May 2023

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Analysis of Demographic and Staging Characteristics in Patients with Colorectal Cancer Using the SEER Registry
Authors: Devanaboyina Monika
Published: May 2023

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Outcomes of Large Colorectal Polyp Endoscopic Resections During Small Audience Live Endoscopy Events with the Endoscopist at Their Home Endoscopy Unit
Authors: El Rahyel Ahmed
Published: May 2023

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ERCP in Patient with Situs Inversus Totalis
Authors: Farrow David
Published: May 2023

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Early Versus Delayed Minimally Invasive Intervention for Infected Pancreatic Necrosis -
Authors: Ghazaleh Sami
Published: May 2023

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Discovery of Gastric Adenocarcinoma during PEG Tube Placement in Patient with Epiglottic Squamous Cell Carcinoma
Authors: Halloran Sean
Published: May 2023

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Gastrointestinal Ulceration as a Manifestation of Severe Dermatomyositis -
Authors: O’Shea Daniel
Published: May 2023

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EUS Guided Through the Needle Biopsy Versus Fine Needle Aspiration for Pancreatic Cystic Lesions:
Authors: Sayeh Wasef
Published: May 2023

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Recurrent Pancreatitis Secondary to Common Channel Volvulus through Petersen’s Space Defect in a Patient with Roux-En-Y Bypass
Authors: Renno Anas
Published: May 2023

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Efficacy and Safety of Cap Assisted vs. Conventional Endoscopic Esophageal Foreign Body Removal -
Authors: Renno Anas
Published: May 2023

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Assessing Resident Confidence in Placing a Central Venous Catheter Before and After a Simulation-Based Training Course
Authors: Pasadyn Vanessa
Published: May 2023

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Mesenteric Mesothelial Cyst a Relatively Rare Complication of Peritoneal Dialysis and Intra-Abdominal Surgical Sequel, Case Presentation
Authors: Rushdi Hadeel I
Published: May 2023

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The Rate of Adverse Events of Sodium-Glucose Cotransporter 2 Inhibitors:
Authors: Sajdeya Omar
Published: May 2023

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Typical Imaging Findings Of TB in an Old Patient with IPF
Authors: Shabpiray Hoda
Published: May 2023

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Natural killer cells: a review of biology,
Authors: Patel Rayna
Published: May 2023

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Daptomycin Associated Rhabdomyolysis with Concurrent Use of Atorvastatin
Authors: Aldhafeeri Abdulaziz
Published: May 2023

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Do Zinc Supplements Reduce Mortality in Patients with COVID-19?
Authors: Abuhelwa Ziad
Published: May 2023

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Impact of a Dedicated Outpatient Parenteral Antibiotic Therapy Clinic on Patient Outcomes
Authors: Ibaraki Makoto
Published: May 2023

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Protease-Inhibitor Binding Reveals Conformational Transition Mechanism
Authors: Nguyen Dylan
Published: May 2023

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Herpes Simplex Virus-1 Encephalitis Secondary to Whole Brain Radiation Therapy
Authors: Waack Andrew
Published: May 2023

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MC1R Deficiency Enhances Th1 Response and Impairs Regulatory T Cell Homeostasis In Nephrotoxic Serum Nephritis
Authors: Chen Bohan
Published: May 2023

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Negative Modulation of B Cell Activation by MC1R Signaling Protects Against Membranous Nephropathy
Authors: Chen Bohan
Published: May 2023

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Disruption of CD40 Results in Significantly Attenuated Renal Inflammation Following Glycerol-Induced Acute Kidney Injury
Authors: Zhang Shungang
Published: May 2023

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Hyperpigmentation in Systemic Sclerosis
Authors: Kelly Gavin
Published: May 2023

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Working To Understand Familial Lung Cancer And Its Genetic Underpinnings
Authors: Knight Connor
Published: May 2023

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Iatrogenic Horner's Syndrome Due to Chest Tube Compression during Decortication
Authors: Meisler Adam
Published: May 2023

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Rare Case of Mantle Cell Lymphoma Presented as Malignant Pleural Effusion and Pleural Nodules
Authors: Noori Zaid
Published: May 2023

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A Roadmap for Michigan’s EV Future: An Assessment of the Employment Effects and Just Transition Needs
Authors: Saha Devashree , Jaeger Joel , Rajpurohit Sujata , Said Evana , Laitner John
Published: May 2023

This report discusses the employment effects of Michigan’s auto industry shifting from internal combustion engine vehicle manufacturing to electric vehicle manufacturing, with a focus on supporting a just transition for workers and communities. Using economic modeling from 2024 to 2040, the report highlights the importance of Michigan seizing the opportunities electrification presents. Additionally, it presents policy recommendations to help Michigan attract and retain good jobs, support workers and ensure local communities benefit from the transition.
KARAKTERISTIK PERUSAHAAN DAN PERATAAN LABA DENGAN KUALITAS AUDIT SEBAGAI VARIABEL MODERASI
Authors:   Universitas Trisakti, Andalawestyas Megha , Ariyati Titik
Published: May 2023

Penelitian ini bertujuan untuk menguji pengaruh karakteristik perusahaan terhadap perataan laba dengan kualitas audit sebagai variabel moderasi. Variabel karakteristik perusahaan yang digunakan dalam penelitian ini adalah umur perusahaan, ukuran perusahaan, solvabilitas, dan kepemilikan manajemen. Sampel dalam penelitian ini adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia pada periode 2015-2018. Pemilihan sampel meggunakan purposive sampling dengan total 320 observasi yang diteliti. Metode analisis ini penelitian menggunakan analisis regresi berganda dengan moderasi. Hasil menunjukkan bahwa umur perusahaan, ukuran perusahaan, dan kepemilikan manajemen berpengaruh negatif terhadap perataan laba sedangkan solvabilitas tidak berpengaruh terhadap perataan laba. Kualitas audit memperkuat hubungan kepemilikan manajemen terhadap perataan laba namun kualitas audit tidak mampu memoderasi hubunganantara umur perusahaan, ukuran perusahaan, dan solvabilitas terhadap kepemilikan manajemen.
TAHAPAN DALAM USULAN PENERAPAN SISTEM INFORMASI AKUNTANSI PADA UMKM SEBAGAI SALAH SATU DAYA UNGKIT STRATEGI BISNIS Studi Kasus UMKM Tuntungan, Desa Baru dan Kota Medan
Authors:   Universitas Methodist Indonesia, Saragih Rintan , Purba Dimita H. P. , Elisabeth Duma Megaria
Published: May 2023

Penelitian ini merupakan lanjutan dari penelitian sebelumnya yaitu penelusuran terhadap lambannya perkembangan UMKM yang disajikan dalam bentuk fish bone diagram. Selanjutnya penelitian ini dilakukan melalui pendekatan kualitatif dan bersifat pespectif emic dengan menggunakan data primer dan data sekunder. Tujuan penelitian yang ingin dicapai adalah untuk memberikan solusi dari permasalahan yang dihadapi oleh responden UMKM terkait dengan pencatatan transaksi keuangan. Lokasi responden UMKM berada di Desa Baru, Tuntungan dan kota Medan. Teknik pengumpulan data menggunakan trianggulasi yang terdiri dari observasi partisipatif, wawancara mendalam/Focus Group Discussion (FGD) dan dokumentasi terhadap responden UMKM. Dalam penentuan responden digunkan metode purposive sampling. Hasil penelitian ditampilkan dalam beberapa data display berupa diagram. Responden dikeompokkan menjadi dua kelompok yaitu (A) responden UMKM yang telah melakukan pencatatan sederhana/manual namun belum ada pemisahan pencatatan keuangan antara binis dan rumah tangga; (B) responden UMKM telah melakukan pencatatan dan telah melakukan pemisahan pencatatan keuangan antara binis dan rumah tangga secara sederhana/manual. Action plan yang disarankan dalam penelitian ini adalah memberikan pelatihan SDM Sistem Informasi Akuntansi yang dilakukan dalam bentuk kegiatan pengabdian kepada masyarakat dan selanjutnya melakukan pendampingan dalam penerapan/impementasi Sistem Informasi Akuntansi bagi responden UMKM. Sehingga dapat membantu responden UMKM dalam mengakses sumber ekonomi dan sekaligus sebagai daya ungkit strategi bisnis.