bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Docking, In silico ADMET Study and Synthesis of Quinoline
Derivatives as Dihydrofolate Reductase (DHFR) Inhibitors: A Solvent-free
One-pot Green Approach Through Sonochemistry
Authors: Mehta Meshwa , Patel Stuti , Patel Ashish , Patel Yug , Shah Drashti , Rathod Keyur , Shah Umang , Patel Mehul , Bambharoliya Tushar
Published: November 2022

Background:

Quinoline derivatives have evinced their biological importance in targeting bacteria
by inhibiting Dihydrofolate reductase. H2SO4 was successfully applied as an acid catalyst for a
green, efficient, and one-pot solvent-free synthesis of quinoline derivatives using sonochemistry approach
from various aromatic amines and glycerol with affording yield up to 96% within 6-10 min.

Objective:

In this study, the synthesis, characterization, and biological assessment of fifteen quinoline
derivatives (1-15) as potential DHFR inhibitors were carried out. The target compounds were docked to
study the molecular interactions and binding affinities with the 1DLS enzyme.

Methods:

The synthesized molecules were characterized using IR, MASS, and 1H and 13C NMR. The Insilico
molecular docking study was carried out through target Human Dihydrofolate Reductase (DHFR)
retrieved from a protein data bank having PDB ID: 1DLS and the antimicrobial activity of all synthesized
compounds were tested against Human Dihydrofolate Reductase(DHFR) enzyme by using in-vitro DHFR
assay kit.

Results:

The molecular docking results revealed that compounds 2 and 6 have the lowest binding energy
and good binding affinity with the DHFR enzyme. In-silico ADMET predictions revealed that all bestscored
compounds had good absorption and drug-like properties for potential use as DHFR inhibitors to
treat bacterial infection. The in vitro studies revealed that compounds 2 and 6 show potent DFHR inhibitory
activity against gram-positive and gram-negative with IC50 = 12.05 ± 1.55 μM and 10.04 ± 0.73 μM,
respectively. While compounds 12, 13, and 15 exhibited moderate antimicrobial activity through DHFR
inhibition with IC50= 16.33 ± 0.73 μM, 17.02 ± 1.55 μM, and 18.04 ± 1.05 μM, respectively.

Conclusion:

This environmentally benign sonochemistry-based approach for synthesizing quinoline derivatives
could be affordable for large-scale production and become a potential lead candidate for developing
a new quinoline-based antimicrobial agent.
Mitochondrial Dysfunction in Neurodevelopmental Disorders: A Systematic
Review on Pathways and Mechanisms
Authors: Upaganlawar Aman B. , Gawali Shweta V. , Marde Vaibhav S. , Kale Nandini B. , Dhokne Mrunali D. , Kale Mayur B. , Wankhede Nitu L. , Taksande Brijesh G. , Umekar Milind J.
Published: November 2022

Background:

Neurodevelopmental disorders (NDDs) are types of disorders that are marked by a wide range of genetic and clinical mutability which will affect the development and function of the brain. Mitochondria are increasingly associated with various neurodevelopmental disorders and it is found because of mutation of mitochondrial genes, which leads to mitochondrial dysfunction.

Objective:

Understanding the pathways and mechanisms of mitochondrial dysfunction related to neurodevelopmental disorders such as ADHD, Pelizaeus-Merzbacher Disease (PMD), mental retardation, Autism spectrum disorder, Rett's syndrome, and Fragile X syndrome is important. In this review, we discussed the possible factors associated with mitochondria that influence the clinical presentation of NDDs, better understanding of the mechanisms behind these pathways will hopefully be helpful for the diagnosis and treatment approaches.

Conclusion:

Mitochondria are simply another subcellular victim of various neurodegenerative pathways, or are they a common denominator on the path to neurodegeneration? A better understanding of functional and molecular mechanistic pathways can lead to the identification of potential targets, thereby opening perspectives for future treatment.
Development of Experimental Teaching Platform for In-Wheel Motor
Electric Vehicle On-Board Testing
Authors: Wang Pan , Fan Xiaobin , Zhu Shuaiwei , He Shuwen , Chen Xinbo
Published: November 2022

Background:

The on-board test system is the key technology of in-wheel motor electric
vehicles, which plays a vital role in the safety of the driver and the efficient operation of the vehicle.

Methods:

Based on the requirements of the current in-wheel motor electric vehicle experiment
teaching content, this research develops an in-wheel motor electric vehicle experimental teaching
platform based on Matlab/Simulink and LabVIEW to meet the current needs of the in-wheel motor
electric vehicle experiment teaching content.

Results:

The vehicle speed, sideslip angle, and road adhesion coefficient can be accurately estimated
using the vehicle test platform developed in the article.

Conclusion:

With accurate experimental results, the functionality, value, and teaching value of the
in-wheel motor electric vehicle experimental teaching platform were fully verified.
Auditory brainstem implantation in children: the case of place of articulation
Authors: Odijk Lotte , Faes Jolien
Published: November 2022

This study aimed to investigate the development of the production of place of articulation of three children with auditory brainstem implants (ABI) in spontaneous speech production. The main participants were three children implanted with an ABI. They were compared against two different control groups: children with a cochlear implant (CI) and children with normal hearing (NH). Data was obtained fromspontaneous speech between the children and their caregivers. For each word production, the place of articulation of both the target word as the child’s own production was identified. This was broadly identified in three categories: labial, coronal and dorsal. The analysis revealed that in general, the coronal place of articulation was most used in all children’s own production, as well as in the target words, except for one child with ABI, who showed a preference for labials. In terms of accuracy, labial place of articulation was produced more accurately than the coronal place of articulation for all children. The dorsal place of articulation had very low accuracy probabilities. Children with ABI had the lowest accuracy rates. When the place of articulation was not correctly produced, they were often omitted instead of replaced by another place of articulation. It was concluded that the children with ABI benefit from their device, but still have a long way to go to catch up to their peers. It is suggested that sign language is needed to guarantee smooth communication. 
Keywords: auditory brainstem implantation; pediatric; oral language, place of articulation;labial; coronal; dorsal
Dutch Norming Study For 208 Color Drawings Depicting Transitive Events
Authors: Sijyeniyo Edwige , Hartsuiker Robert J. , Bernolet Sarah
Published: November 2022

We conducted a norming study amongst Dutch children (6-12 years) to investigate whether they would correctly  interpret our set of 208 color drawings, developed for  longitudinal research on the production and comprehension of transitive sentences, if the transitive action on each drawing was described with an active or a  passive sentence. The children provided 93.02% correct answers to our pictures, which indicates that the pictures are clear in terms of how the transitive actions are displayed. There were several factors that contributed to an incorrect interpretation of a transitive action in a picture. (1) Pictures were more difficult to interpret when a passive  sentence was used to describe a transitive event compared to an active sentence; (2) children made more errors interpreting pictures when abstract verbs, such as  “inhalen” (to overtake) and “vervangen” (to replace), were used to describe a transitive event; (3) children had difficulty interpreting our pictures when particular verbs (“roepen” [to shout] and “volgen” [to follow]) were  presented in a passive sentence, while other verbs  (“blokkeren” [to block] and “inhalen”) rendered more  correct answers when the transitive event was described  with a passive sentence; finally, (4) younger children  provided more incorrect answers to our pictures than older children, regardless of whether the transitive action in the picture was described with an active or a passive sentence. In particular, the younger children provided significantly more incorrect answers to pictures with the verb “groeten” (to greet) compared to the older children. Because our set contains many verb-noun combinations, the set is very useful to researchers who intend to investigate the  acquisition of transitive structures in children in a  longitudinal design, not only for studies with typically developing children, but also in studies with children who  have a delay in their language development. Keywords: Norming study, picture set, transitive structures, L1 syntax acquisition.
The language of school writing: a developmental comparison of genres across the school years
Authors: Haim Leah , Ravid Dorit
Published: November 2022

Writing is the highway to learning, processing, organizing, storing and retrieving information during the school years. Gaining command of the structures and functions of texts of different genres is one of the main goals of linguistic literacy in education. The texts that school-goers construct provide optimal hunting grounds for unveiling their linguistic abilities during the genre-specific construction of different text types. The current study examines the linguistic constructions typical of expository texts, characterized by argumentation or persuasion regarding social / conceptual issues, versus informative texts, describing factual (or less controversial) phenomena. This examination constitutes a window on Hebrew-speaking students’ developing writing abilities in elementary, middle and high school, compared with adults. Participants were 547 students and educated adults with post-high school education. Each participant wrote an informative text and an expository text, yielding a total of 1,094 texts. Three types of variables were examined: lexical, morpho-syntactic and syntactic. We found that complex lexicon and syntax in discourse increased in prevalence across the school years, with specific structures being genre-typical as befits the stance and character of the two genres under investigation. We also found that it was only in adulthood that all of these components were employed in optimal fashion, at the culmination of the period of Later Language Development. Our results imply that informative and expository texts are indeed distinct in their characteristics, and that it takes many years of internal linguistic and cognitive development, on the one hand, and schooling instruction and experience, on the other hand, to achieve qualitative academic writing in non-experts.
Thermodynamics and kinetics of elastic calorific effect in shape memory alloys
Authors: Malygin G. A.
Published: November 2022

The mechanism of elastic calorific effect in crystals of alloys with SME is theoretically discussed within the framework of the theory of diffuse thermoelastic martensitic transitions, that the structural transitions in alloys with shape memory effect (SME) are. The theory provides an adequate description of the elastic calorific effect under adiabatic unloading of the crystal and stable behavior of the martensitic transition. Flexibility of the theory is also applicable to kinetically unstable (with a burst) martensitic transitions caused by structural features of the crystal, as is the case, according to literature, of Ni50Fe19Ga27Co4 alloy crystal compression along the direction of [011]. Key words: alloys with SME, elastic calorific effect, thermoelastic martensitic transitions, stable and unstable kinetics of martensitic transition.
The Association Between Clinical Severity and Incubation Period of SARS-CoV-2 Delta Variants: Retrospective Observational Study
Authors: Wang Kai , Luan Zemin , Guo Zihao , Ran Jinjun , Tian Maozai , Zhao Shi
Published: November 2022

Background

As of August 25, 2021, Jiangsu province experienced the largest COVID-19 outbreak in eastern China that was seeded by SARS-CoV-2 Delta variants. As one of the key epidemiological parameters characterizing the transmission dynamics of COVID-19, the incubation period plays an essential role in informing public health measures for epidemic control. The incubation period of COVID-19 could vary by different age, sex, disease severity, and study settings. However, the impacts of these factors on the incubation period of Delta variants remains uninvestigated.

Objective

The objective of this study is to characterize the incubation period of the Delta variant using detailed contact tracing data. The effects of age, sex, and disease severity on the incubation period were investigated by multivariate regression analysis and subgroup analysis.

Methods

We extracted contact tracing data of 353 laboratory-confirmed cases of SARS-CoV-2 Delta variants’ infection in Jiangsu province, China, from July to August 2021. The distribution of incubation period of Delta variants was estimated by using likelihood-based approach with adjustment for interval-censored observations. The effects of age, sex, and disease severity on the incubation period were expiated by using multivariate logistic regression model with interval censoring.

Results

The mean incubation period of the Delta variant was estimated at 6.64 days (95% credible interval: 6.27-7.00). We found that female cases and cases with severe symptoms had relatively longer mean incubation periods than male cases and those with nonsevere symptoms, respectively. One-day increase in the incubation period of Delta variants was associated with a weak decrease in the probability of having severe illness with an adjusted odds ratio of 0.88 (95% credible interval: 0.71-1.07).

Conclusions

In this study, the incubation period was found to vary across different levels of sex, age, and disease severity of COVID-19. These findings provide additional information on the incubation period of Delta variants and highlight the importance of continuing surveillance and monitoring of the epidemiological characteristics of emerging SARS-CoV-2 variants as they evolve.
Establishment of the visualization platform for ADR query and analysis: an example of severe skin adverse reactions caused by sulfonylureas (Preprint)
Authors: Huang Ya-Min , Zhang Lu , Huang Hang-Xing , Huang Ling , Yu Hui-Min , Li Jing-Yang , Chen Xiao-Ping , Chen Yao , Zhang Hong-Yan , Gan Yuan , Cheng Shu-Qiao , Xiao Jian
Published: November 2022

BACKGROUND

Driven by concerns about adverse drug reactions among medical staff and the general public in the context of pharmacovigilance innovations, we developed and validated a visualization platform for query and analysis exploiting FDA adverse event reporting system data(FAERS). A case study of the association between sulfonylureas and serious skin adverse reactions to validate platform usability.

OBJECTIVE

Our goal was to facilitate the utilization of FAERS data by medical personnel and general public by introducing a visualization platform for ADR query and analysis, and promote the development of PV further.

METHODS

For users to utilize FAERS data directly, we performed appropriate data acquisition, cleaning and subsequent platform interface and functional development of available data. In order to evaluate the usability of the platform, we elaborated a case study of serious skin adverse reactions caused by sulfonylureas.

RESULTS

We developed a visualization platform which can directly query and analyze adverse reaction signals based on FAERS data. The platform consisted of five components, including the login page, multi-condition query, drug and adverse reaction query, primary ID query and data download interface. The high usability of the platform was verified by demonstrating the signal mining results of serious skin adverse reactions caused by sulfonylureas and visualizing information.

CONCLUSIONS

The visualization platform and verification cases constructed in this study could provide a suitable framework and method for drug safety research, which was expected to promote the development of pharmacovigilance.
Engaging Parents in Technology-Assisted Interventions for Childhood Adversity: Systematic Review (Preprint)
Authors: Aldridge Grace , Tomaselli Alessandra , Nowell Clare , Reupert Andrea , Jorm Anthony , Yap Marie Bee Hui
Published: November 2022

BACKGROUND

Youth mental health problems are a major public health concern and are strongly associated with adverse childhood experiences (ACEs). Technology-assisted parenting programs can intervene with ACEs that are within a parent’s capacity to modify. However, engagement with such programs is suboptimal.

OBJECTIVE

This review aims to describe and appraise the efficacy of strategies used to engage parents in technology-assisted parenting programs targeting ACEs on the behavioral and subjective outcomes of engagement.

METHODS

Using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) reporting guidelines, we conducted a systematic review of peer-reviewed papers that described the use of at least 1 engagement strategy in a technology-assisted parenting program targeting ACEs that are within a parent’s capacity to modify. A total of 8 interdisciplinary bibliographic databases (CENTRAL, CINAHL, Embase, OVID MEDLINE, OVID PsycINFO, Scopus, ACM, and IEEE Xplore) and gray literature were searched. The use of engagement strategies and measures was narratively synthesized. Associations between specific engagement strategies and engagement outcomes were quantitatively synthesized using the Stouffer method of combining P values.

RESULTS

We identified 13,973 articles for screening. Of these, 156 (1.12%) articles were eligible for inclusion, and 29 (18.2%) of the 156 were associated with another article; thus, 127 studies were analyzed. Preliminary evidence for a reliable association between 5 engagement strategies (involving parents in a program’s design, delivering a program on the web compared to face-to-face, use of personalization or tailoring features, user control features, and provision of practical support) and greater engagement was found. Three engagement strategies (professional support features, use of videos, and behavior change techniques) were not found to have a reliable association with engagement outcomes.

CONCLUSIONS

This review provides a comprehensive assessment and description of the use of engagement strategies and engagement measures in technology-assisted parenting programs targeting parenting-related ACEs and extends the current evidence with preliminary quantitative findings. Heterogeneous definition and measurement of engagement and insufficient engagement outcome data were caveats to this synthesis. Future research could use integrated definitions and measures of engagement to support robust systematic evaluations of engagement in this context.

CLINICALTRIAL

PROSPERO CRD42020209819; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=209819
Isolation and Human Rights: Arendt and the Charter at Forty
Authors: Kellogg Catherine
Published: November 2022

Great excitement greeted the Canadian Charter of Rights and Freedoms because it promised to deliver constitutionally enshrined equality rights (among other things) to all Canadian citizens. Those who had been formerly excluded from full civil and social participation because of social inequalities, prejudice, and bias would now be included in a new social compact. And, as the title of the conference that inspired this paper suggests, that promise was also that those isolated as a result of those exclusions, no longer would be.
Two Roads to Guantanamo: The Canadian and United States Supreme Courts’ Approaches to the Extraterritorial Application of Fundamental Rights
Authors: Thurschwell Adam
Published: November 2022

Following Catherine Kellogg’s engagement with Hannah Arendt’s question of whether there are modes of non-nationalist belonging, I begin with the recognition that the moment when the “nation-state ... will nullify itself as such” still lies far in the future, if it ever occurs at all. Real (as opposed to ideal) history happens through incremental, fragile evolutionary change, not through sudden leaps from one fundamental paradigm to another. If the ideal of the self-nullifying nation-state is an intellectual fantasy, however, it is also an ideal in the Kantian sense, one that can motivate and orient political action. Indeed, it is precisely the contingency of actual history that makes space for real-world political movements of groups and individuals that change paradigms from within.
Ефективність нуклеотидів у лікуванні периферичних нейропатій і радикулопатій
Authors: Oros M.M.
Published: November 2022

Дана стаття присвячена вивченню ефективності й безпеки нуклеотидів на прикладі препарату Аксотроф у практиці лікування нейро- і радикулопатій. Висвітлено основні фармакодинамічні механізми дії препарату Аксотроф. Проведені дослідження показали, що даний засіб характеризується добрим профілем безпеки, його тривалий прийом не супроводжується виникненням суттєвих побічних ефектів та ускладнень. У той же час підкреслюється, що включення нуклеотидів у комплекс лікувальних заходів при ураженнях периферичних нервів дозволяє підвищити результативність лікування і зменшити термін відновного періоду. Вищеописані якості дозволяють рекомендувати препарат Аксотроф для широкого загалу пацієнтів з нейропатіями і радикулопатіями.
Деякі питання артеріальної гіпертензії та інсульту
Authors: Zozulya I.S. , Volosovets A.O.
Published: November 2022

Мозковий інсульт є однією із найбільш поширених першопричин інвалідизації та смертності населення нашої країни. Серед пацієнтів, які перенесли інсульт, повторні інфаркти мозку зустрічаються у 27–30 %, а протягом 5 років — у 50 %. Найбільш ймовірним результатом після інсульту (окрім летального) є інвалідизація, яка може досягати 80 %, з яких частка тих, хто потребує сторонньої допомоги, становить 30 %. Повне регресування симптомів може становити 11–12 %. Тому питання діагностики, клініки, лікування і особливо надання допомоги на ранніх етапах завжди є актуальними. У статті наведені патогенетичні механізми порушення мозкового кровообігу за ішемічним типом, більш детально висвітлена одна із головних причин інсультів — гіпертонічна хвороба. Висвітлені головні завдання, які стоять перед медичною та соціальною спільнотою щодо профілактики цереброваскулярних захворювань, надання екстреної медичної допомоги при інсультах.
Analysis of Leachate from the Municipal Solid Waste Disposal Site and Its Impact on Ground Water Quality At, Lucknow Cantonment
Authors: Vishwakarma Siddharth
Published: November 2022

Abstract: Open dumping of municipal solid waste is prone to groundwater contamination because of leachate production. In this report, an attempt has been made to assess the pollution potential of leachate generated from the solid waste disposal site and its impact on aquifers in Neil line Lucknow environs, Uttar Pradesh, India. Physico-chemical parameters of leachate are determined to evaluate water quality index (WQI) .A large amount of the water requirement of Lucknow City is supplied from groundwater. The quality of this groundwater was determined by taking samples from wells within the study area. The purposes of this investigation were .To provide an overview of present groundwater quality . To determine spatial distribution of groundwater quality parameters such as pH, electrical conductivity, Cl− , SO4 −2 , hardness, and NO3− concentrations, and.To map groundwater quality in the study area by using GIS and Geostatistics techniques. ArcGIS 9.0 and ArcGIS Geostatistical Analyst is used for generation of various thematic maps and ArcGIS Spatial analyst to produce the final groundwater quality map .
Analysis of Leachate from the Municipal Solid Waste Disposal Site and Its Impact on Ground Water Quality at Lucknow Cantonment
Authors: Vishwakarma Siddharth , Gupta Anirudh
Published: November 2022

Abstract: Open dumping of municipal solid waste is prone to groundwater contamination because of leachate production. In this report, an attempt has been made to assess the pollution potential of leachate generated from the solid waste disposal site and its impact on aquifers in Neil line Lucknow environs, Uttar Pradesh, India. Physico-chemical parameters of leachate are determined to evaluate leachate pollution index (LPI) .A large amount of the water requirement of Lucknow City is supplied from groundwater. The quality of this groundwater was determined by taking samples from wells within the study area. The purposes of this investigation were to provide an overview of present groundwater quality. To determine spatial distribution of groundwater quality parameters such as pH, electrical conductivity, Cl− , SO4 −2 , hardness, and NO3− concentrations, and To map groundwater quality in the study area by using GIS and Geostatistics techniques. ArcGIS 9.0 and ArcGIS Geostatistical Analyst is used for generation of various thematic maps and ArcGIS Spatial analyst to produce the final groundwater quality map .
The Effects of Young Children's Self-regulation and Paternal Involvement on Maternal Parenting Stress
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Song Joung-Mi , Moon Hyuk-Jun
Published: November 2022

Objectives The purposes of this study were to investigate the general trend of young children's self-regulation, paternal involvement, and maternal parenting stress, examine the relationship among the three variables, and analyze how young children's self-regulation and paternal involvement affect maternal parenting stress. Methods To this end, 213 preschoolers and their mothers from 10 daycare centers in Gyeonggi-do were selected as subjects. SPSS 25.0 program were used to conduct descriptive analysis and Pearson's correlations analysis. Finally, multiple regression analysis was conducted to find out their effects. Results The results of this study showed that the average of young children's self-regulation, paternal involvement, and maternal parenting stress were all higher than the average group, and the self-regulation and paternal involvement were negatively correlated with maternal parenting stress. In addition, when examining the effects of young children's self-regulation and paternal involvement on maternal parenting stress, behavioral inhibition was significantly effective on daily stress, and all sub-factors of the self-regulation were influenced on parental role and distress. Conclusions This study is significant in that it verified the variable that predicts maternal parenting stress with examining the personal variable of preschoolers and parenting environment variable which are currently highlighted, and sorting through the sub-factors of maternal parenting stress.
Léo Dandurand, nationalisme canadien-français et baseball: Quand la sainte flanelle transpose sa formule aux autres sports
Authors: Carpentier Patrick , Trudeau Christian
Published: November 2022

Leo Dandurand is best known for his success as owner of the Montreal Canadiens, successfully positioningthe team as by and for French Canadians. In 1924, fresh off a Stanley Cup win, he tried his hand atbaseball, taking over a team in the Class B Eastern Canada League. He brought the same philosophy to thediamond, vowing to recruit as many French Canadians as possible. Even if the team had little success on thefield and at the gate, Dandurand’s philosophy still had a lasting impact, notably through his influence as a boardmember of the Montreal Royals.
Re-thinking Architecture Education: Conceptualising Curriculum Through the Lens of 21st Century Graduate Attributes
Authors: Ng Veronica , L.L Chia
Published: November 2022

There has been a paradigm shift in architecture education to embrace the 21st century attributes for graduates. While attributes such as problem solving, critical and creative thinking, interpersonal and intrapersonal skills, and technological as well as global awareness have been central to the curriculum design in architectural education, this paper posits the need to critically examine the emerging 21st century attributes, and how they can be embedded into architecture education. In recent years, it is clear that these attributes have been designed and executed into design and other-related student projects through either extra-curricular platforms or at modular level, however there is a lack of exploration of these attributes as structured and intentional design at curriculum level. Using design research in education as the methodology for study, this paper explores the design thinking for architecture education that embraces these attributes. This paper justifies and argues for the need to re-think architectural education in relation to these attributes and offers a conceptual thinking, framework and principles for curriculum design.
ESCOLA E CIDADANIA: PRÁTICAS DIALÓGICAS E INTERPRETATIVAS NUMA ESCOLA DO BAIRRO RESTINGA, PORTO ALEGRE/RS
Authors: Oliveira Aigner Carlos Henrique
Published: November 2022

Este texto traz reflexões sobre a importância das práticas educativas, construídas a partir da contextualização do lugar e do protagonismo dos sujeitos que atuam no espaço escolar. Descreve e analisa as narrativas e experiências didático-pedagógicas, realizadas em uma instituição municipal de ensino fundamental, localizada no bairro Restinga, em Porto Alegre/RS. As práticas relatadas, deram origem à produção de um material didático que valoriza a história e a geografia do lugar, que vem sendo utilizado em escolas do bairro, evidenciando a perspectiva dos sujeitos que nele vivem e serviram como instrumento catalizador de relações dialógicas entre os diversos segmentos da comunidade escolar, promovendo a produção de saberes que conduziram a ações educativas, que marcaram a trajetória dos sujeitos em suas comunidades. Tem como objetivo contribuir para a compreensão do papel da escola pública e das atividades pedagógicas, voltadas à formação para a cidadania.
Thematic analysis of the responsibilities of the board of directors in OECD, BCBS, and IFSB principles
Authors: Naim Nizar Yousef Ahmed , Rahman Nora Azureen Abdul
Published: November 2022

At the center of this ongoing debate is the board of directors’ responsibilities, nevertheless, there are differences and similarities among the principles and guidelines of corporate governance worldwide when it comes to responsibilities of the board of directors. The interest in corporate governance and, specifically, the focus on bank governance have received increased attention from academics and policymakers after the global financial crisis of 2007–2009 (Pathan & Faff, 2013). Given the gap in the literature investigating these differences and similarities, this theoretical article aims to conduct a thematic analysis of the principles and guidelines of the Organisation for Economic Co-operation and Development (OECD), Basel Committee on Banking Supervision (BCBS), and Islamic Financial Services Board (IFSB), on board of directors’ responsibilities. This article provides a reference thematic analysis for policymakers, regulators, and researchers in developing national corporate governance principles and guidelines. The article highlights the shares themes between the principles of OECD, BCBS, and IFSB, and concludes with recommendations for future research in the area of the board of directors’ responsibilities.
Procedural Sedation for Pediatric Patients with Spinal Muscular Atrophy Undergoing Intrathecal Treatment
Authors: Sever Feyza , Özmert Sengül , Öz Nefise Arıbaş
Published: November 2022

Aims: Nusinersen is administered intrathecally for treating spinal
muscular atrophy (SMA). Procedural sedation is common with intrathecal
treatment in children. This retrospective study presents our experience
with procedural sedation during the intrathecal treatment of pediatric
patients with SMA I, II, and III. Methods: Data were collected the from
the anesthesia charts and electronic medical records of 14 pediatric
patients with SMA types I, II, and III who underwent procedural sedation
for repeated intrathecal treatments for SMA. Intravenous induction was
performed, and patients were oxygenated with a face mask or nasal
cannula while spontaneous breathing continued. Results: Fourteen
patients were included in the study: one SMA I, eight SMA II, and five
SMA III. They underwent 88 intrathecal nusinersen injections totally. In
the one SMA I patient, of eight months, the procedure was performed
under local anesthesia. In all other patients, the treatments were
performed under procedural sedation. Different combinations of
midazolam, ketamine, propofol, fentanyl, and remifentanil were used. The
mean doses of the agents used were 0.03 mg/kg, 0.97 mg/kg, 2.71 mg/kg,
0.84 mcg/kg and 0.5 mcg/kg respectively. There were no intraoperative or
postoperative complications. Conclusion: We found the procedural
sedation to be sufficient, effective, and safe in SMA II and III
pediatric patients who underwent nusinersen treatment intrathecally,
provided anesthetic agents are titrated.and administered carefully.
Phase Current based Fault Section Location for Single-Phase Grounding Fault in Non-Effectively Grounded Distribution Network
Authors: chang zhongxue , Chang Nana , Zhang Wei , Zhang Chenhao , Song Guobing , Liu Jian , Zhang Zhihua , Tan Weibin
Published: November 2022

Zero-sequence voltage and current based single-phase grounding (SPG)
fault detection and location methods in non-effectively grounded
distribution network have limitations in practical use due to lack of
zero-sequence CT and PT in some cases. To deal with this problem, the
phase current characteristics under SPG fault are analysed and the SPG
fault detection method and section location method is proposed.
PSCAD-based simulation results and fault recording data show that the
proposed method behaves well when SPG fault with different impedances
occurs in different sections. The proposed method can select the faulty
phase automatically without using voltage signals, which is suitable for
all IEDs.
Development and Application of a Motivating Factors Evaluation Scale for Family Doctors in China
Authors: Meng Kai , Zhai Ziyan , Wang Yu , Lv Bo , Cui Chengsen
Published: November 2022

Objective: To establish a reasonable incentive mechanism for
FDs and increase their work motivation, it is necessary to evaluate the
incentive status of FDs. At present, there is no scale evaluating
motivating factors for FDs. This study aims to develop and validate an
instrument to evaluate the status of FD incentives. Methods: We
used literature review and panel discussion to form the initial
evaluation tool of family doctor motivating factor. Then a questionnaire
survey was conducted among 4988 medical staff in 8 districts of Beijing.
The data were analyzed by item analysis, exploratory factor analysis,
confirmatory factor analysis, and reliability evaluation of the data,
and the developed scale was used for empirical research to evaluate the
incentive level of FDs in Beijing. Results: The scale included
18 items in 4 dimensions: incentive payment, individual development,
work values, and the organizational environment. The variance explained
by the four common factors was 83.78%. The results of the EFA and the
CFA proved that the questionnaire had good validity. The Cronbach’s
alpha for the total scale was 0.979. There were differences in FD
incentive levels by region, age, educational level, professional title,
working years, and employment method. Conclusions: The family
doctor motivating factor evaluation scale has good reliability and
validity. The scale evaluation results show that the motivation of FDs
with different demographic characteristics in Beijing is different in
terms of incentive levels.
Numerical analysis of reaction kinetic accompanying flow and dispersion in structured ZSM-5@SiC open-cell foam catalyst
Authors: Yan Peng , Ding Qiuyan , Zou Jing , Na Jian , Geng Xueli , Li Hong , Gao Xin
Published: November 2022

Chaotic flow inside porous media accelerates the transport, mixing, and
reaction of molecules and particles in widespread natural and factitious
processes. Current macroscopic models based on the average pore-scale
variations show obvious limitations in the prediction of many chemical
processes. In this paper, we reconstruct microscopic foam structures
using Micro Computed Tomography to simulate fluid flow in structured
ZSM-5@SiC foam catalyst. Moreover, we propose a conceptual model based
on the microscopic mean square displacement theory to characterize the
effective dispersion inside an open-cell foam. This model will explain
the flow characteristics of confined fluid inside the porous media from
fluid elements perspective. Particularly, dispersion factor and
structure factor, as key parts of this model, perfectly interpret the
driving characteristics of pressure drop, velocity different, and
reaction in continuous foam media flow. This work also provides a unique
means of predicting reaction kinetics of confined fluid in structured
foam catalyst.
Improvement of modeling on the Pidgeon process for magnesium production by introducing the variable thermophysical properties
Authors: Li R.-B. , Wang C. , Wang Z. , Yang P.-X. , Xue F. , Liu F.-Q. , Zhang S.-J.
Published: November 2022

The variable thermophysical properties were introduced into the coupling model of heat transfer and reduction reaction in the Pidgeon process to improve the accuracy of the numerical calculation. The distribution of temperature and magnesium reduction extent in the briquette layer, and the total magnesium reduction extent in the retort were investigated. The model results show better agreement with those of industrial production. The feature of ?layer shift? in the briquette layer during the reduction process was clearly shown. It was shown that the reduction reaction occurs only at a thin interface. The slag layer with lower thermal conductivity of 0.4 W.m-1.K-1 formed during reduction strongly hinders the reaction to move forward within the layers, resulting in the slow magnesium production rate in the Pidgeon process. The improved model can provide a more accurate quantitative prediction for magnesium reduction in the Pidgeon process, which is important for key equipment innovation and the development of new magnesium production techniques.
N-end rule-mediated proteasomal degradation of ATGL promotes lipid storage
Authors: Xu Jiesi , Liu Zhenglong , Zhang Jianxin , Chen Siyu , Wang Wei , Zhao Xuefan , Zhen Mei , Huang Xun
Published: November 2022

Cellular lipid storage is regulated by the balance of lipogenesis and lipolysis. The rate-limiting triglyceride hydrolase ATGL (desnutrin/PNPLA2) is critical for lipolysis. The control of ATGL transcription, localization and activation has been intensively studied, while regulation of the protein stability of ATGL is much less explored. Here we showed that the protein stability of ATGL is regulated by the N-end rule in cultured cells and in mice. The N-end rule E3 ligases UBR1 and UBR2 reduce the level of ATGL and affect lipid storage. The N-end rule-resistant ATGL(F2A) mutant, in which the N-terminal phenylalanine (F) of ATGL is substituted by alanine (A), has increased protein stability and enhanced lipolysis activity. ATGLF2A/F2A knock-in mice are protected against high-fat diet (HFD)-induced obesity, hepatic steatosis and insulin resistance. Hepatic knockdown of Ubr1 attenuates HFD-induced hepatic steatosis by enhancing the ATGL level. Finally, the protein levels of UBR1 and ATGL are negatively correlated in the adipose tissue of obese mice. Our study reveals N-end rule-mediated proteasomal regulation of ATGL, a finding which may potentially be beneficial for treatment of obesity.

  
Tomato: A Model Plant to Study Plant-Pathogen Interactions
Authors: M Meena
Published: November 2022

Tomato (Solanum lycopersicum) is a very important vegetable plant in the worldwide because of its importance as food, quality of fruit, improves productivity, and resistance to biotic and abiotic stresses. Tomato has been extensively used not just for food however conjointly as a research (plant-pathogen interactions) material. Generally, most of the tomato traits are agronomically imperative and cannot be studied using other model plant systems. It belongs to family Solanaceae and intimately associated with several commercially important plants like potato, tobacco, peppers, eggplant, and petunias. Production of tomato yield is affected each year due to range of pathogenic diseases that square measure caused by fungi, bacteria, viruses and roundworm, enlarge all the methods through soil-borne, above-ground infections and in some instances are transmitted through insect feeding. This review is focused on the way to tomato-pathogen interactions analysis is very important and role of pathological processes connected factors and genes.
Stress Affected Date Palm and Modified Treatments: A Review
Authors: SS Rasmia Darwesh
Published: November 2022

Salt stress soil or water come to be the most problem and deficiency the crop yields, in spite of the fact that date palm (Phoenix dactylifera L.) can be tolerate high levels of salts, the acclimatized plantlets in the early stage facing stress just planted in the open field, however in the pre-acclimatization stage in vitro , also after acclimatization stage in the greenhouse these plantlets were adapted with different concentrations of salts NaCl, CaCl2 for helping them facing bad effects of salts in the fields, as well as many treatments can be done to ameliorate the bad effects of salts on the plantlets as hormons (IAA, GA3, cytokinins), yeast, amino acids, potassium K+ or Ca2+ and some of growth retardants, all of these treatments have important role to adverse bad effects of salts, enhancing growth as well as improving productivity of plants under salts stress.
Chitosan Edible Coatings with Geraniol or Vanillin: A Study on Fresh-Cut Strawberries Microbial and Sensory Quality Through Refrigerated Storage
Authors: B Tomadoni
Published: November 2022

Edible coatings (ECs) are a good strategy to extend shelf-life of fruit products. For this purpose, the use of polysaccharides such as chitosan (CH) are gaining popularity. In this study, chitosan coatings were evaluated in fresh-cut strawberries microbial and sensory quality through refrigerated storage at 5°C for 7 days. Also, two natural antimicrobial agents, i.e. vanillin (V) and geraniol (G), were incorporated in the coatings and evaluated at two different concentrations. In general, chitosan coatings were effective in the initial reduction of fresh-cut strawberries native microflora, even without the incorporated biopreservatives. However, through storage, neither of the coatings tested was able to control the growth of mesophilic bacteria. Among the tested sensory parameters, texture was the most important characteristic, which governed the shelf-life of the product
Evaluation of Health Status and Histo-Architecture of Heterobranchus Longifilis and Clarias Buthupogon Obtained from Asa River, Nigeria
Authors: OM Akinloye
Published: November 2022

Gross impact of water pollution and water borne pollutants on aquatic organisms and man has become a great concern to public health in the recent time. Therefore, the aim of this study was to evaluate the effects of pollutants from the polluted Asa River on the liver histology of Clarias buthupogon and Heterobranchus longifilis. The sample included a total of 55 individuals (28 for C. buthupogon and 27 for H. longifilis).There was a recorded moderate to intense alterations of liver tissues. The most notable alterations were congestion of central vein, degeneration of hepatocyte, sinusoidal distortion, cellular inflammation and necrosis. However, all histological alterations recorded in the liver tissues were most likely to be caused by increased concentrations of certain pollutants from industrial, domestic and agricultural premises. Furthermore, these results represent an additionalreason to proceed with a detailed monitoring of the Asa River and the wildlife therein, for the sake of public health.
Screening of Tolerant Genotypes of Spring Barley for Terminal Drought Stress Based on Grain Yield and Yield Components
Authors: Pecio Alicja
Published: November 2022

The pot experiment with spring barley was carried on in 2011 and 2013-2014 years. The total number of 263 genotypes was tested against short-term drought stresses introduced at the tillering stage for 11 days or at full flag leaf stage for 14 days. At the control treatment, plants were grown at the optimal soil moisture level of 13-15% weight by weight for the whole vegetation period and in the stress treatments, the moisture was maintained at the level of 5-6% weight by weight. Spring barley showed a higher tolerance to the drought stress at tillering stage than at flag leaf stage. Barley genotypes differed in their response to terminal drought stresses due to diverse ability for regenerating after the stress removal. The resistance and tolerance of the genotypes to the drought stress imposed at tillering stage resulted from their ability to produce additional fertile tillers and to the stress at flag leaf stage by compensation of the reduced grain number per spike through increasing the weight of 1000 grains. The grain yield of tolerant genotypes named as MCAM: 85, 86, 102, 128 and 129 was stable independent on water supply and the most suitable for breeders in Poland.
Effect of Storage Time on Spiced Non-Alcoholic Beverage Made from Tiger-Nut Blends (Kunun Aya)
Authors: AC Wada
Published: November 2022

Kunun-aya is a traditional non-alcoholic beverage widely consumed in Northern Nigeria especially during the dry season. The beverage was prepared from tiger nut with the addition of spices such as cloves, date and ginger at different ratio of blends. The samples were stored at 4°C for 5 days and the effects of spices on their proximate, microbial and sensory properties were evaluated. Fresh tiger nuts and spices were purchased from Kure Ultra-modern market in Minna, Niger State. The tiger nut seeds were sorted and foreign materials, bad/cracked nuts, which may affect the taste and keeping quality of the drink were removed, washed and rinsed with portable water then soaked overnight to soften the fibre and to remove off-flavour. One kilogram of the fresh tiger nuts was blended several times into slurry with water. The slurry was pressed using muslin cloth to recover the extract. A 9-point hedonic scale was used to assess the sensory attributes of the spiced drink based on mouth feel, texture, taste, aroma, appearance and general acceptability. Five samples of the spiced drink were analyzed for total energy, crude protein, fat, carbohydrate, ash, crude-fibre and moisture contents. Results of the proximate analyses revealed a range of 87.4-90.0% for moisture which was high. The crude protein ranged from 3.3-3.6 with t h e samples containing tiger nut and date b e i n g significantly different from the others. The fat content ranged from 2.5-4.8, while the energy and carbohydrate contents ranged between 56.6-71.7 and 1.74-6.1 respectively. The bacterial count of the Kunun-aya samples ranged from 1.2 - 9.2×104 CFU/ml and fungal count ranged from 1.2-9.0×104 CFU/ml on days 1, 3 and 5, respectively. Bacterial and fungal counts of the samples generally increased with the storage period and the samples with 20% inclusion of clove and 10% inclusion of ginger, clove and date respectively were the most acceptable among the treated samples. No significant differences existed among the treated samples in terms of mouth feel, aroma, taste, consistency and appearance. The study revealed a nutritious and acceptable spiced drink from tiger- nut which can serve as a substitute to alcoholic and carbonated beverages.