bluuebunny/crossref_metadata_2025 huggingface dataset:
Autoreactive napsin A–specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade
Authors: Berner Fiamma , Bomze David , Lichtensteiger Christa , Walter Vincent , Niederer Rebekka , Hasan Ali Omar , Wyss Nina , Bauer Jens , Freudenmann Lena Katharina , Marcu Ana , Wolfschmitt Eva-Maria , Haen Sebastian , Gross Thorben , Abdou Marie-Therese , Diem Stefan , Knöpfli Stella , Sinnberg Tobias , Hofmeister Kathrin , Cheng Hung-Wei , Toma Marieta , Klümper Niklas , Purde Mette-Triin , Pop Oltin Tiberiu , Jochum Ann-Kristin , Pascolo Steve , Joerger Markus , Früh Martin , Jochum Wolfram , Rammensee Hans-Georg , Läubli Heinz , Hölzel Michael , Neefjes Jacques , Walz Juliane , Flatz Lukas
Published: September 2022

Cancer treatment with immune checkpoint blockade (ICB) often induces immune-related adverse events (irAEs). We hypothesized that proteins coexpressed in tumors and normal cells could be antigenic targets in irAEs and herein described DITAS (discovery of tumor-associated self-antigens) for their identification. DITAS computed transcriptional similarity between lung tumors and healthy lung tissue based on single-sample gene set enrichment analysis. This identified 10 lung tissue–specific genes highly expressed in the lung tumors. Computational analysis was combined with functional T cell assays and single-cell RNA sequencing of the antigen-specific T cells to validate the lung tumor self-antigens. In patients with non–small cell lung cancer (NSCLC) treated with ICB, napsin A was a self-antigen that elicited strong CD8
+
T cell responses, with ICB responders harboring higher frequencies of these CD8
+
T cells compared with nonresponders. Human leukocyte antigen (HLA) class I ligands derived from napsin A were present in human lung tumors and in nontumor lung tissues, and napsin A tetramers confirmed the presence of napsin A–specific CD8
+
T cells in blood and tumors of patients with NSCLC. Napsin A–specific T cell clonotypes were enriched in lung tumors and ICB-induced inflammatory lung lesions and could kill immortalized HLA-matched NSCLC cells ex vivo. Single-cell RNA sequencing revealed that these T cell clonotypes expressed proinflammatory cytokines and cytotoxic markers. Thus, DITAS successfully identified self-antigens, including napsin A, that likely mediate effective antitumor T cell responses in NSCLC and may simultaneously underpin lung irAEs.
Immune thrombocytopaenic purpura following the second dose of Pfizer COVID-19 vaccine
Authors: Latef Taroob , Howard Leslie , Loke Chandravathi , Tsui Edison
Published: September 2022

Immune thrombocytopaenic purpura (ITP) is often a diagnosis of exclusion with presentations ranging widely from asymptomatic patients to those with life-threatening bleeding. Secondary ITP following vaccination is relatively uncommon and underdiagnosed as majority of patients remain asymptomatic. Cases of severe thrombocytopaenia associated with SARS-CoV-2 messenger RNA (ribonucleic acid) vaccinations have been described previously, mostly as isolated occurrences, and typically occurring following the first dose. Here we present a case of severe ITP associated with the second dose of the Pfizer-BioNTech/BNT16B2b2 mRNA vaccine and provide a review of the current literature.
Gnotobiotic mice housing conditions critically influence the phenotype associated with transfer of faecal microbiota in a context of obesity
Authors: Daoust Laurence , Choi Béatrice S-Y , Agrinier Anne-Laure , Varin Thibault V , Ouellette Adia , Mitchell Patricia L , Samson Nolwenn , Pilon Genevieve , Levy Emile , Desjardins Yves , Laplante Mathieu , Anhê Fernando F , Houde Vanessa P , Marette Andre
Published: September 2022

Objective

Faecal microbiota transplantation (FMT) in germ-free (GF) mice is a common approach to study the causal role of the gut microbiota in metabolic diseases. Lack of consideration of housing conditions post-FMT may contribute to study heterogeneity. We compared the impact of two housing strategies on the metabolic outcomes of GF mice colonised by gut microbiota from mice treated with a known gut modulator (cranberry proanthocyanidins (PAC)) or vehicle.

Design

High-fat high-sucrose diet-fed GF mice underwent FMT-PAC colonisation in sterile individual positive flow ventilated cages under rigorous housing conditions and then maintained for 8 weeks either in the gnotobiotic-axenic sector or in the specific pathogen free (SPF) sector of the same animal facility.

Results

Unexpectedly, 8 weeks after colonisation, we observed opposing liver phenotypes dependent on the housing environment of mice. Mice housed in the GF sector receiving the PAC gut microbiota showed a significant decrease in liver weight and hepatic triglyceride accumulation compared with control group. Conversely, exacerbated liver steatosis was observed in the FMT-PAC mice housed in the SPF sector. These phenotypic differences were associated with housing-specific profiles of colonising bacterial in the gut and of faecal metabolites.

Conclusion

These results suggest that the housing environment in which gnotobiotic mice are maintained post-FMT strongly influences gut microbiota composition and function and can lead to distinctive phenotypes in recipient mice. Better standardisation of FMT experiments is needed to ensure reproducible and translatable results.
AAC Kongsore oat
Authors: Fetch Jennifer W. Mitchell , Entz Martin , Fox Stephen L. , Spaner Dean , Stanley Katherine , Carkner Michelle , Fetch T.G. , McCartney C.A. , Menzies J.G. , Wang X. , Ames N. , Nilsen K.T. , Burt A. , Kumar S. , Hamilton K.D. , Green D.A. , Dyck W. , Stewart K. , Cormack B.
Published: September 2022

AAC Kongsore is a white-hulled spring oat ( Avena sativa L.) cultivar selected and developed under organic management. AAC Kongsore had high yields under organic and conventional production systems, compared to check cultivars (AAC Oravena, Leggett, AC Morgan and CDC Dancer). AAC Kongsore has good physical and milling quality traits.
The influence of freeze–thaw cycles on the mechanical properties of paleosols: based on a multiscale research
Authors: Yiqian Chen , Peiran Zhang , Yang Bai , Zihao Zhou , Yongxin Che , Huimin Yang
Published: September 2022

To investigate the multiscale effects of freeze–thaw cycles on the mechanical properties and structural damage of paleosols, remodeled paleosol specimens at natural moisture content were subjected to multiple freeze–thaw cycles, followed by scanning electron microscopy, nuclear magnetic resonance (NMR) pore testing, and triaxial shear testing, and then the shear strength deterioration mechanism of paleosols was elaborated on from three aspects: fine, mesoscopic, and macroscopic. The main experimental results were as follows: (1) at the fine level, the NMR T2 spectrum distribution curve showed one primary and two secondary peaks, in which the main spectrum occupied the majority, and the spectrum area showed an exponential function distribution relationship with the number of freeze–thaw cycles. With the accumulation of freeze–thaw cycles, the medium and large pores increased significantly. (2) At the mesoscopic level, when the specimens underwent freeze–thaw cycles, the interparticle contact pattern and particle morphology changed and the particle roundness increased. As the freeze–thaw cycle continued, fissures gradually developed and increased the most after the first freeze–thaw cycle, but the probability entropy of soil particles showed a decreasing trend with the increase of the number of freez–thaw cycles. (3) At the macro level, the number of freeze–thaw cycles gradually accumulated, the specimen stress–strain curve softened significantly, the shear strength deterioration effect was obvious, the deterioration value was the largest after one freeze–thaw cycle and gradually stabilized after 10 cycles, and the deterioration effect of cohesion was greater than that of the internal friction angle.
Selected Topics of the Past Thirty Years in Ocean Acoustics
Authors: Collins Michael D. , Turgut Altan , Buckingham Michael J. , Gerstoft Peter , Siderius Martin
Published: September 2022

This paper reviews some of the highlights of selected topics in ocean acoustics during the thirty years that have passed since the founding of the Journal of Theoretical and Computational Acoustics. Advances in computational methods and computers helped to make computational ocean acoustics a vibrant area of research during that period. The parabolic equation method provides an unrivaled combination of accuracy and efficiency for propagation problems in which the bathymetry, sound speed, and other environmental parameters vary in the horizontal directions. The extension of this approach to cases involving layers that support shear waves has been an active area of research throughout the thirty year period. Interest in basin-scale and global-scale propagation was stimulated by the Heard Island Feasibility Test for monitoring climate change in terms of changes in travel time that occur as the temperature of the ocean rises. Diminishing ice cover in the Arctic, which is one of the consequences of climate change, has stimulated renewed interest in Arctic acoustics during the past decade. Reverberation is a challenging problem that was the topic of a major research program during the beginning of the thirty year period. An innovative approach for making it feasible to solve such problems was applied to data for reverberation from the seafloor and from schools of fish, and some of the findings were featured in Science and Nature. Source localization is one of the core problems in ocean acoustics. When applied on a 2-D array of receivers, an approach based on the eigenvectors of the covariance matrix is capable of separating the signals from different sources from each other, determining when this partitioning step is successful, and tracking sources that cross each other in bearing; one of the advantages of this approach is that it does not require environmental information or solutions of the wave equation. Geoacoustic inversion for estimating the layer structure, wave speeds, density, and other parameters of ocean bottoms has also been a topic of interest throughout the thirty year period.
An operator view on trends in core acquisition
Authors: Saucier Dave , Sincock Kevan
Published: September 2022

Core samples from the subsurface can provide unambiguous direct information to guide operator decisions. Core may be acquired with drilling equipment (full-bore core) or by post-drill wireline methods (sidewall core). Both approaches have distinct profiles of cost, risk, sample type and value, and an operator must select the most appropriate to progress business in an informed way.

The option to selectively core after drilling and perceptions of lower cost and risk might indicate that sidewall coring will always be the best approach. Recent developments to increase the size and quality of rotary sidewall samples would only add weight to this view.

It is not all good news for sidewall core, however. Individual sample size and total volume delivered per run are tiny; weak rock or high overbalance pressure may cause poor recovery and biased datasets; time between drilling and logging allows mud invasion and borehole relaxation, so samples are often broken and pore fluids contaminated. Sidewall sample sets therefore leave a higher degree of uncertainty when compared to full-bore core.

It is this operator's view that both approaches have a role to play in reducing subsurface uncertainty, and cost, risk and value should be carefully considered when deciding which to apply.
Introduction to the Special Issue on Test Methods for Human-Robot Teaming Performance Evaluations
Authors: Marvel Jeremy A. , Bagchi Shelly , Zimmerman Megan , Aksu Murat , Antonishek Brian , Wang Yue , Mead Ross , Fong Terry , Amor Heni Ben
Published: September 2022

This special issue of the Transactions on Human-Robot Interaction highlights, documents, and explores the metrics, test methods, and artifacts used in human-robot interaction (HRI) research. This collection of articles brings to attention the commonalities between the application of measurement science for the assessment and assurance of human-centric robotics in a variety of application domains, including industry, education, and defense. This special issue draws specific attention to the use and impact of metrology toward the advancement of HRI technologies and algorithms, and it promotes the application of measurement science toward the benchmarking and replication of HRI research. Special attention is given to the use cases, data sets, test methodologies, measurement techniques, metrics, and statistical analyses used to evaluate system performance.
Breaking CaptchaStar Using the BASECASS Methodology
Authors: Hernández-Castro Carlos , Barrero David F. , R-Moreno Maria Dolores
Published: September 2022

In this article, we present fundamental design flaws of CaptchaStar. We also present a full analysis using the BASECASS methodology that employs machine learning techniques. By means of this methodology, we find an attack that bypasses CaptchaStar with almost 100% accuracy.
Properly Learning Decision Trees in almost Polynomial Time
Authors: Blanc Guy , Lange Jane , Qiao Mingda , Tan Li-Yang
Published: September 2022

We give an
n

O
(log log
n
)

-time membership query algorithm for properly and agnostically learning decision trees under the uniform distribution over { ± 1}

n

. Even in the realizable setting, the previous fastest runtime was
n

O
(log
n
)

, a consequence of a classic algorithm of Ehrenfeucht and Haussler.

Our algorithm shares similarities with practical heuristics for learning decision trees, which we augment with additional ideas to circumvent known lower bounds against these heuristics. To analyze our algorithm, we prove a new structural result for decision trees that strengthens a theorem of O’Donnell, Saks, Schramm, and Servedio. While the OSSS theorem says that every decision tree has an influential variable, we show how every decision tree can be “pruned” so that
every
variable in the resulting tree is influential.
An Ultra-Thin Crosslinked Carbonate Ester Electrolyte for 24 V Bipolar Lithium-Metal Batteries
Authors: Chen Xi , Sun Chuankui , Wang Kai , Dong Wei , Han Jinlong , Ning De , Li Yongli , Wu Wei , Yang Chunlei , Lu Ziheng
Published: September 2022

Fabrication of an ultrathin solid electrolyte with high conductance is essential to achieve high energy density of solid-state batteries. As solid polymer electrolytes (SPEs) are characterized by good ductility, ease of manufacturing, and low cost, the current solvent-based casting pathway suffers from the difficulty in controlling the thickness. In addition, the low ionic conductivity and narrow electrochemical window of the polyether-type SPEs further hinder their practical applications. We fabricate an ultra-thin solid-polymer electrolyte by in situ polymerization of carbonate ester vinyl ethylene carbonate and poly(ethylene glycol) diacrylate using a porous polypropylene membrane as a support. The obtained solid electrolyte is of only 8 μm and possesses an unprecedented ionic conductance of 83.3 mS at room temperature. Furthermore, the electrolyte is compatible with Li metal and can suppress dendrite growth. An all-solid-state lithium battery based on LiFePO4 cathode can operate stably for over 150 cycles with 86% capacity retention. The non-fluidic nature of the electrolyte further enables the fabrication of an energy-dense 24 V bipolar pouch cell which demonstrates extreme flexibility and safety. No voltage drop is observed upon folding and cutting. This in situ polymerized ultra-thin electrolyte provides a promising platform for the fabrication of high-energy solid-state batteries and also a potential candidate for flexible batteries.
Microstructural Analysis of Effective Electrode Conductivity in Molten Salt, Na-ZnCl2 Batteries
Authors: Godinez-Brizuela O. E. , Niblett Daniel , Einarsrud Kristian E.
Published: September 2022

Intermediate temperature molten salt batteries are a promising alternative for grid-scale energy storage with several advantages over existing solutions. The cathode of some of these batteries is composed of a porous matrix of materials containing the metal backbone of the electrode, along with electrolyte components that vary and different locations or as the state of charge of the battery changes. In this work, we aim to analyze the influence of the microstructural properties of the cathodic region at different compositions for a Na-Zn (ZnCl2) battery. Synthetic geometric models of the electrode at different compositions are generated and then the effective conductivity is estimated through numerical simulation of the current and potential distribution through the material. At a three-phase composition used by a typical electrode assembly, the effective conductivity is approximately three times larger than the electrolyte electrical conductivity.
Microstructural Adjusting Crack Evolution of Polycrystalline NCM Particle during Charge/Discharge Cycle
Authors: Tian Hao , Gao Li Ting , Guo Zhan-Sheng
Published: September 2022

The occurrence of cracks inside LiNixCoyMn1-x-yO2 (NCM) polycrystalline particles induced by charge/discharge limits their applications. In this study, a chemomechanical damage model was established to obtain insight into the crack characterization of NCM secondary particles induced by the charge/discharge processes. Two key factors (the primary particle sizes and regularities) that govern the microstructures, were included in the geometrical model established using the Voronoi algorithm. Cohesive elements were inserted into the primary particle edges to perform a comprehensive simulation of interparticle cracks. Different crack characterizations in cycle processes were disclosed through a discussion of stress, crack evolution and morphology, and damage degree. The primary particle size and regularity have significant effects on both the crack morphology and damage degree. Tensile stress contributes the most to charge-induced cracks, whereas both tensile and shear stresses are the main contributors to discharge-induced cracks. The accumulation of deformation energy plays a vital role in the discharge process. The discharge process causes more damage than the charge process under high fracture energies, but this can be transferred when the fracture energy decreases. The phenomena and mechanisms offer a comprehensive understanding of the charge/discharge-induced degradation in NCM secondary particles and can guide the rational design of microstructures.
A Collaborative Estimation Scheme for Lithium-Ion Battery State of Charge and State of Health Based on Electrochemical Model
Authors: Wu Sheyin , Pan Wenjie , Zhu Maotao
Published: September 2022

Nowadays, many studies focus on single state of health (SOH) or state of charge (SOC) estimation. How to effectively combine the two for joint estimation is particularly important. This paper relies on our previous research foundation of SOH, and further increases the electrochemical model, and realizes the SOC estimation of the battery under different SOH stages by combining the two. An SPM model based on electrochemical mechanism is proposed and sensitivity analysis is performed for the parameters in the model. Three types of dynamic conditions, FUDS, BJDST and DST, are used to verify the feasibility of the model. Further, the synergistic estimation of SOH and SOC is realized by the change of the difference between the two lithium ion concentrations with the battery decay when SOC = 100% and SOC = 0% in the SPM model. In the offline state, a linear regression relationship is constructed between the results of the GPR model and the parameters of the SPM model. During online prediction, the parameters of SPM are obtained by calibrating the offline model, and the goal of estimating SOC based on SOH is realized. The experimental results show that the maximum error value of SOC estimation does not exceed 0.08, and the model has high accuracy.
Computational Studies of Super-B as Anodes for AM (Li, Na, and K) Ion Batteries
Authors: Khan Muhammad Isa , Anwar Maida , Majid Abdul , Shakil Muhammad , Rizwan Muhammad
Published: September 2022

Energy storage systems have recently become the focus of current research for mankind’s future. This study, as per the features of super-B reported recently, is being explored as an anode material in alkali metal (Li, Na, and K) ion batteries. After adsorption of AM (Li, Na, and K) concentration, the metallic behavior of the super-B remains preserved even at the maximum level. The hollow site (H) appeared as a favorable site among all studied sites for adsorption metal-ion on super-B. Alkali metals adsorption on super-B yielded maximal theoretical capacities of 3718 mhAg−1. The open-circuit voltage (OCV) was found 0.35, 0.81 and 1.39 V for AM (Li, Na, and K) decorated super-B. Furthermore, the lower diffusion barrier was calculated for Li (0.14 eV) and K (0.44 eV) along with the H-T-H, while 0.16 eV for Na along with the H-B-H site. The lower OCV, ultra-fast diffusion barrier, and high specific theoretical capacity show that this newly discovered super-B is a promising candidate to be utilized as an anode material in metal-ion batteries.
A Modeling Framework of Electrochemo-mechanics of Lithium-ion Battery: Part II. Porous Electrodes with Contact Stress Effect
Authors: Fang Ruqing , Li Zhe
Published: September 2022

Extended from the electrochemo-mechanical single particle model, an electrochemo-mechanical impedance model for porous electrode in LIB, which consider the effect of the contact stress, is proposed in this work. A modified coefficient

ζ

which links the mechanical properties of the electrode and particle material is introduced to describe the effect of contact stress. Firstly, we find that the contact stress can weaken the stress-induced semicircle in the low frequency range through analyzing the Faradaic part of the impedance. Secondly, considering the contact stress is determined by the mechanical bonding between electrode layer and the current collector, we introduce a pseudo-elastic boundary condition to analyze the bonding effect. For rigid substrate, namely the in-plane deformation is totally restricted, the effect of the contact stress is strong. For free substrate, namely the in-plane deformation is not restricted, the contact stress is not induced thus its effect on impedance disappears. Lastly, we discuss the interaction effect of stress and the ionic transport in the electrolyte and find that the interaction is strong for silicon-based material, which indicates the stress effect needs to be considered when interpreting the impedance data in this case.
Characteristics of Anode Materials for Nickel Electroforming
Authors: Green T. A. , Tambe C. Enowmbi , Roy S.
Published: September 2022

This study comprised an investigation of the characteristics of commercial nickel anode materials routinely employed in sulfamate-based electroforming processes. These included examples of sulfur depolarised anodes containing a relatively high sulfur content and those with much lower levels. Electrochemical studies indicate that the sulfur depolarised anodes underwent dissolution in the active region and were capable of sustaining large current densities at low potentials without passivating, and with current efficiencies approaching 100%. In contrast, low-sulfur containing anodes could only sustain low current densities in the active region, and were prone to passivation. These materials could only undergo high rate dissolution in the transpassive region, but this required relatively high anode potentials and was accompanied by various side reactions which lowered the current efficiency. Additional studies were performed to characterise the sulfamate oxidation products which generates a distinct UV absorption band at 245 nm. These species were produced only when low-sulfur content or inert (platinum) anodes were used, and were absent when sulfur depolarised anodes were employed. The principal anode product was azodisulfonate, but trace amounts of other sulfonate species and sulfur-containing anions may also be present.
Dielectric Behavior Investigation of Composite Materials Based on Epoxy Resin/Fe3O4/CaTiO3, SrTiO3 Using Mixture Laws
Authors: Delfouf R. , Bouzit N. , Bourouba N. , Brahimi A. , Jiménez J. P. Martinez
Published: September 2022

In the same matrix of epoxy resin, Fe3O4 powder was evenly mixed with one of two titanate powders, CaTiO3 or SrTiO3. The dielectric properties of these blends were evaluated using the measurement technique of time domain spectroscopy (TDS). During this work, low-frequency analyzes (DC − 300 MHz) were carried out, mainly focusing on the static permittivity and conductivity properties as a function of titanate concentrations. The results allowed us to confirm the validity and effectiveness of the modified Lichtenecker Laws (MLL). Significant agreement accord can be shown between the MLL-calculated and experimentally determined permittivity values for ternary combinations. The perspective of this research lies in the production of new materials for use in the field of telecommunications and in particular for microelectronic components.
Analog and Digital Performance of Graphene-Germanene-Graphene Heterojunction Based Field Effect Transistor
Authors: Vali Mehran
Published: September 2022

In this study, by taking the advantage of electrical properties of graphene, silicene and germanene sheets we propose and analyze a heterojunction based field effect transistor. It is comprised of germanene sheet in the channel and gapless graphene in the source/drain regions. We investigate and compare the performances of proposed device from two points of view comprised of analog and digital applications. A comparative study is carried out with three other simulated devices including gapless graphene, germanene and graphene-silicene-graphene heterojunction based field effect transistors. Our theoretical analysis show that for digital applications, Ion/Ioff ratio in the proposed graphene-germanene-graphene (G-Ge-G) heterojunction based field effect transistor shows a significant better value than other counterpart simulated devices and reaches to 106. However for the analog applications, the output characteristic curves show different behavior for the simulated devices under study. The output characteristic of (G-Ge-G) heterojunction based field effect transistor displays a very good saturation which owes to improved pinch-off in the channel.
Gender-affirming estrogen therapy route of administration and cardiovascular risk: a systematic review and narrative synthesis
Authors: Turino Miranda Keila , Kalenga Cindy Z. , Saad Nathalie , Dumanski Sandra M. , Collister David , Rytz Chantal L. , Lorenzetti Diane L. , Chang Danica H. , McClurg Caitlin , Sola Darlene Y. , Ahmed Sofia B.
Published: September 2022

This study is the first to summarize the potential effect of nonoral versus oral gender-affirming estrogen therapy use on cardiovascular risk factors in transgender women or nonbinary or gender-diverse individuals. Heterogeneity of studies in reporting gender-affirming estrogen therapy formulation, dose, and duration of exposure limits quantification of the effect of gender-affirming estrogen therapy on all-cause and cardiovascular mortality, adverse cardiovascular events, and cardiovascular risk factors. This systematic review highlights the needs for large prospective cohort studies with appropriate stratification of gender-affirming estrogen therapy by dose, formulation, administration route, and sufficient follow-up and analyses to limit selection bias to optimize the cardiovascular care of transgender, nonbinary, and gender-diverse individuals.
Effects of Occlusal Plane Inclination on the Temporomandibular Joint Stress Distribution: A Three-Dimensional Finite Element Analysis
Authors: Cifter Ebru Demet
Published: September 2022

Background. Sudden changes in masticatory loads and occlusal conditions contribute to temporomandibular disorders. Clockwise (CW) or counterclockwise (CCW) rotation of the occlusal plane is one of the factors that alter the direction of the occlusal forces transmitted to the temporomandibular joint structures. Finite element analysis was used to identify possible regions of high stress in the temporomandibular joint. Materials and Methods. A computer-aided design model of a symmetrical edentulous maxillomandibular bony complex with a temporomandibular joint was manually generated using Rhinoceros 4.0 freeform modeling software. Three-dimensional discrete mesh generation was performed using VRMesh Studio. The reference occlusal plane angle was accepted as 8° in the sagittal plane, and by modifying 4° in the CW and CCW directions, CW and CCW models were obtained, respectively. The present study aimed to evaluate the changes in stress distribution in the condylar cartilage and temporomandibular disc using the von Mises and maximum-minimum principal stress evaluations of three different occlusal plane inclinations. The null hypothesis of this three-dimensional finite element analysis was that “occlusal plane inclination does not change the stress distribution on the temporomandibular joint structures.” Results. The compressive stress on the condyle increased with CW rotation of the occlusal plane. The von Mises equivalent stress of the temporomandibular disc shifted to the medial, posterior, and superior directions after CW and CCW rotations of the occlusal plane. The CW rotation of the occlusal plane increased the von Mises equivalent.
Granulomatosis with Polyangiitis Overlapping with IgG4-Related Disease
Authors: Pistone Aureliano , Soyfoo Muhammad
Published: September 2022

IgG4-related disease and granulomatosis with polyangiitis share several features as well as the presence of ANCA antibodies and serum IgG4 immunoglobulins. It is often difficult to distinguish between two entities. We hereby report the case of a patient portraying the clinical conundrum with clinical and biological features of the two diseases.
[Retracted] Investigation of the Effects of Large Bone Flap Craniotomy on Cerebral Hemodynamics, Intracranial Infection Rate, and Nerve Function in Patients with Severe Craniocerebral Trauma
Authors: Li JiNan , Zhang XinLi , Su Hang , Qu YaNan , Piao Meixuan
Published: September 2022

In order to explore the clinical value of large bone flap craniotomy, the effects of standard large bone flap craniotomy on cerebral hemodynamic indexes, incidence of postoperative intracranial infection, and neurological function in patients with severe craniocerebral trauma are investigated. 89 patients with severe craniocerebral trauma admitted from January 2020 to June 2021 are analyzed retrospectively. All patients are divided into a large craniotomy group (n = 45) and control group (n = 44) according to different surgical methods. The large craniotomy group is treated with large craniotomy decompression, and the control group is treated with traditional craniotomy decompression. The incidence of intracranial infection in each group is recorded, and NIHSS is applied to observe the neurological function recovery of 2 groups before and 1 month after operation. Besides, the patients are followed up after surgery and the Kaplan–Meier survival curve is obtained to compare the survival rate of patients in the two groups. It is clearly evident that the two surgical methods have certain clinical efficacy in the treatment of patients with severe craniocerebral trauma. Comparatively, the large craniotomy can further improve brain blood supply and improve neurological function recovery. Also, it can obtain low incidence of postoperative adverse reactions and intracranial infection.
[Retracted] Expression of SOCS1 Protein in Endotoxin‐Tolerant Mouse Model and Its Regulation Mechanism by mir‐150
Authors: Quan Hui , Jin Wenhu , Zhang Ziyang , Xie Meng , Xin Chun
Published: September 2022

In order to investigate the expression of Suppressor of Cytokine Signaling 1 (SOCS1) and its regulatory mechanism by mir‐150 in a lipopolysaccharide (LPS) tolerant mouse model of endotoxin, a total of 60 male BALB/C mice were randomly divided into 2 groups. The LPS is used to construct the endotoxin resistant mouse model and the mice are included in the model group (n = 30), 0.9% sodium chloride injection is used to construct the normal control group (n = 30). And tumor necrosis factor‐α (TNF‐α) is determined by Elisa to determine whether the model was successfully constructed. The correlation between SOCS1 protein and mir‐150 is analyzed by the Pearson correlation coefficient. In the experiments, the results show that the expression of TNF‐α in the macrophage fluid of the model group is significantly decreased (P < 0.05), indicating that the endotoxin tolerance mouse model is successfully constructed, so the secretion of TNF‐α is reduced.
Cultivation Design of Applied Undergraduates’ Engineering Innovation Ability Based on Virtualization Technology
Authors: Zhao Qiuduo , Xiong Chen , Liu Ke , Zhang Xudong , Liu Zhao
Published: September 2022

The development of virtualization technology has promoted the development of computers in education, and the reform of basic education courses has promoted profound reforms in science education. The integration of virtualization technology and science teaching is an inevitable trend in the development of information technology and science education, and it is also training the inevitable requirement of talents with scientific culture and innovation ability. This article takes undergraduates as the research object and aims at the application characteristics of local higher education institutions, combined with the purpose of higher technical personnel training, application practical ability, and innovation ability, to establish a training system for college students with innovation ability suitable for engineering application undergraduate talent training mode, and improve students’ research and innovation ability and engineering practice ability. This article proposes to organically integrate virtualization technology with undergraduate students’ engineering innovation ability training courses, explore virtual technology experimental models, cognitive models, promote student self-study and student mutual learning, where students actively participate, and strengthen student innovation and creativity training. Improve the ability of design and transform teacher education into student-centered. The results of the study show that students’ innovative ability generally accounts for 56%, and the effects of innovative activities organized by schools generally account for as high as 70%. Students are generally not very enthusiastic about innovation.
[Retracted] Efficacy and Safety of Amniotic Membrane Transplantation Combined with Closure of Tenon Capsule and Bulbar Conjunctival Space in the Treatment of Primary Pterygium
Authors: Chen Jingyao , Zheng Yixin , Zhang Weijia , Zhao Zijun , Xu Yanze
Published: September 2022

Objective. The aim of the study is to evaluate the safety and effectiveness of amniotic membrane transplantation combined with the closure of the tenon capsule and bulbar conjunctival space. Methods. This study retrospectively included 100 patients with primary pterygium who received closed bulbar conjunctiva and tenon capsule space combined with amniotic membrane transplantation in our hospital from January 2020 to June 2021 as the experimental group and 100 patients with routine treatment in the same period as the control group. The postoperative efficacy evaluation and postoperative complications of the two groups were compared, so as to comprehensively evaluate the safety and effectiveness of this method. Results. The results showed that the postoperative complications of the two groups were significantly improved by Fisher’s exact test (χ2 = 14.510, P = 0.006 < 0.05). The comparison results showed that the treatment group showed significant advantages in six indexes compared with the observation group and the difference between the two groups was statistically significant (P < 0.05) of in the NRS score, Prabhasawat score, inspection of the ocular surface comprehensive analyzer, corneal fluorescein staining, conjunctival fluorescein staining in the operation area, breakup time of tear film examination of the two groups at 3, 7 and 14 days, and 1, 6 and 12 months after the operation. Conclusions. Amniotic membrane transplantation combined with the closure of the tenon capsule and bulbar conjunctival space is safer than conventional surgery in the treatment of primary pterygium. It has a shorter recovery time, higher safety, and a positive curative effect. It can be considered to popularize this operation in clinic.
Exploring the Impacts of Students in Hospitality Programs of Vocational High Schools Watching YouTubers’ Travel Programs on Travel Intention from the Perspective of Digital Business Opportunities in the Postpandemic Era
Authors: Tsou Yi-Ta , Lin Hsiao-Hsien , Chen Wei-Cheng , Chen Chao-Chien , Fang Rui-Wen , Hsu Chin-Hsien
Published: September 2022

The purpose of this study is to explore the impacts of students in the hospitality programs of vocational high schools watching YouTubers’ travel programs on their travel intentions, as viewed from the perspective of digital business opportunities in the postpandemic era. Students in the hospitality programs of vocational high schools were taken as the research subjects, and a questionnaire survey was conducted with convenience sampling. A total of 350 questionnaires were distributed, and 320 questionnaires were recovered for a recovery rate of 91%. After 35 invalid questionnaires were excluded, there were 285 valid questionnaires for an effective recovery rate of 89%. The software, Statistical Package for the Social Sciences and Analysis of Moment Structures, was used for statistical analysis. The research results show that (1) there was no significant difference between different background variables in travel intention; (2) the degree of involvement had a significant impact on travel intention; (3) trust had a significant impact on travel intention; (4) perceived value had a significant impact on travel intention; and (5) destination image had a significant impact on travel intention. Finally, based on the results of this study, relevant suggestions were provided for practical application.
Computer Network Security Management of Data Encryption Technology
Authors: Sun Caiping , Wang Weijiang
Published: September 2022

With the continuous promotion of high and new technologies such as computers and big data, humans enter a new period-information age. Mass data and information can be transmitted and exchanged online through the network. In recent years, research on image encryption based on optical information processing technology is becoming more and more favored by researchers. In this regard, this study will focus on the research of encryption algorithms in optical images and realize encryption through fractional Fourier transform and Arnold transform. This article first introduces the research background of the subject and analyzes the current situation of the subject at home and abroad and then proposes the theoretical guidance basis for the subject research, which covers the fractional Fourier transform, Arnold transform, computational hologram, and picture evaluation index system. Finally, MATLAB simulation and performance analysis are carried out for fractional Fourier transform, Arnold transform, and holographic encryption technology. The results shows that the improved algorithm in this study performs better in the encryption and decryption process.
Profile of Transepidermal Water Loss (TEWL), Skin Hydration, and Skin Acidity (pH) in Indonesian Batik Workers
Authors: Prakoeswa Cita Rosita Sigit , Damayanti  , Anggraeni Sylvia , Umborowati Menul Ayu , Febriana Sri Awalia , Oginawati Katharina , Tanziha Ikeu
Published: September 2022

Chemical substances used during batik processing may affect the physiological function of the batik worker’s skin barrier. This study assessed the level of transepidermal water loss (TEWL), skin hydration, and skin acidity in 61 batik workers from the batik center in Paseseh village, Tanjung Bumi subdistrict, Madura Island, Indonesia. Forty‐five batik workers involved in dry work including drawing patterns on the cloth with wax and sixteen batik workers involved in wet work including dyeing the cloth with a dye bath were included in this study. The mean TEWL level in the dry work section was 59.87 ± 11.94 g/m2/h on the palmar and 29.00 ± 13.09 g/m2/h on the dorsal side of the hand, while the mean TEWL in the wet work section were 47.39 ± 9.66 g/m2/h on the palmar and 37.07 ± 10.00 g/m2/h on the dorsal side of the hand. The mean skin hydration level in the dry work section was 49.80 ± 19.16 arbitrary units (a.u.) for the palmar side and 52.77 ± 16.21 a.u. for the dorsal side of the hand, while the mean levels of skin hydration in the wet work section were 47 ± 12.73 a.u. and 62.94 ± 10.09 a.u. for palmar and dorsal side, respectively. The mean levels of skin acidity in the dry work section were 5.45 ± 0.19 for the palmar side and 5.30 ± 0.20 for the dorsal side of the hand, while the wet work section had 5.30 ± 0.19 and 5.10 ± 0.19 for the palmar and dorsal side of the hand, respectively. The TEWL levels were found to be higher on the palmar side of the hand in both the dry work and wet work sections, which was consistent with the measurement of skin hydration levels that were lower on the palmar side of the hand. The mean skin pH levels for both work sections were considered within the normal range.
Convolutional Neural Network-Based Mining of Civic Science Elements and Teaching Practice
Authors: Li Wenhua
Published: September 2022

In the context of the big data era, a model for mining Civics elements using convolutional neural networks is proposed to address the problems of poor interaction between teaching practice and Civics elements. The use of this model for the mining and teaching practice of Civics elements allows teachers to make changes to the design of teaching contents in real time in order to maximize the integration of lecture contents and Civics elements. In addition, in order to improve the effectiveness of the model, an improved model with A-Softmax algorithm and softmax output layer fusion is proposed, and the experiment proves that the improved model has a certain degree of improvement in performance.
Investigation on Depression of College Students Majoring in Physical Education and Nonphysical Education: A StudyBased on the Age Region and Gender of 374 Students
Authors: Ding Xiaofen , Tang Nian
Published: September 2022

In the research on the relationship between depression and college students’ major, there are some differences in the degree of depression between sports major and nonsports major students. Based on these results, we assume that there is the possibility of emotional differences between professional and nonprofessional sports. A total of 374 samples of students majoring in physical education and nonphysical education at the same university were analyzed by using the methods of literature review and data analysis. A total of 188 subjects, including 121 males and 253 females (186 majoring in sports and nonsports), were asked to fill in the SDS (Self-Rating Depression Scale). SDS is widely used in rough screening, emotional state evaluation, investigation, and scientific research of outpatients in clinical psychology departments. The research obtained the difference in depression degree in the whole sample and further compared the depression degree of students of different ages and native places. Statistical analysis was performed on all data using SPSS 23.0 software. Basic data description, paired chi-square analysis, and covariance analysis were used. The results show that in this sample, the maximum value (minimum/maximum value) of one item of the total depression score of nonphysical education students exceeds the average value by 3 standard deviations, and this shows that the general level of depression scores of non-PE majors is high; most non-PE majors are in mild depression, which is equal to the number of PE majors who are in a normal mood; and nonsports majors in cities are more likely to have mild depression.
[Retracted] A Rehabilitation Model Conducive to Postoperative Recovery of Endometrial Cancer Patients after Laparoscopy
Authors: Yang Li , Han Feng
Published: September 2022

Although collaborative care is increasingly being implemented in the treatment of various diseases, there are currently no related studies on its effects in endometrial cancer patients after laparoscopic treatment. Thus, this study is aimed at investigating the significance of an integrated medical and nursing care model for women with gynecologic malignant tumors who underwent laparoscopic treatment. The patients were randomly divided into a medical‐nursing integrated nursing group (study group) and a general nursing group (control group). Their serum carbohydrate antigen 19‐9 (CA19‐9), human epididymal protein 4 (HE4), CA15‐3, and CA125 levels were measured at admission, 7 and 15 days after admission, and 30 days after discharge. Their first postoperative flatulence time, eating time, and hospitalization duration were recorded, and the self‐rating anxiety scale (SAS) and self‐rating depression scale (SDS) were used to evaluate the psychological state of the patients. A questionnaire survey was also used to evaluate their satisfaction with nursing. Adverse events within 2 years of follow‐up were recorded. The results showed that the clinical performance of the study group was significantly better than that of the control group. Further, the study group demonstrated significantly lower serum tumor marker levels, SAS score, SDS score, and incidence of adverse events at 7 and 15 days after admission and 30 days after discharge and higher nursing satisfaction than the control group. Thus, the collaborative nursing mode might be more conducive to the recovery of women who have underwent laparoscopic treatment for gynecologic malignant tumors than normal routine nursing.
Progenitor Hierarchy of Chronic Myelomonocytic Leukemia Identifies Inflammatory Monocytic-Biased Trajectory Linked to Worse Outcomes
Authors: Ferrall-Fairbanks Meghan C. , Dhawan Abhishek , Johnson Brian , Newman Hannah , Volpe Virginia , Letson Christopher , Ball Markus , Hunter Anthony M. , Balasis Maria E. , Kruer Traci , Ben-Crentsil Nana Adjoa , Kroeger Jodi L. , Balderas Robert , Komrokji Rami S. , Sallman David A. , Zhang Jing , Bejar Rafael , Altrock Philipp M. , Padron Eric
Published: September 2022

Myeloblast expansion is a hallmark of disease progression and comprises CD34+ hematopoietic stem and progenitor cells (HSPC). How this compartment evolves during disease progression in chronic myeloid neoplasms is unknown. Using single-cell RNA sequencing and high-parameter flow cytometry, we show that chronic myelomonocytic leukemia (CMML) CD34+ HSPC can be classified into three differentiation trajectories: monocytic, megakaryocyte-erythroid progenitor (MEP), and normal-like. Hallmarks of monocytic-biased trajectory were enrichment of CD120b+ inflammatory granulocyte–macrophage progenitor (GMP)-like cells, activated cytokine receptor signaling, phenotypic hematopoietic stem cell (HSC) depletion, and adverse outcomes. Cytokine receptor diversity was generally an adverse feature and elevated in CD120b+ GMPs. Hypomethylating agents decreased monocytic-biased cells in CMML patients. Given the enrichment of RAS pathway mutations in monocytic-biased cells, NRAS-competitive transplants and LPS-treated xenograft models recapitulated monocytic-biased CMML, suggesting that hematopoietic stress precipitates the monocytic-biased state. Deconvolution of HSPC compartments in other myeloid neoplasms and identifying therapeutic strategies to mitigate the monocytic-biased differentiation trajectory should be explored.

Significance:

Our findings establish that multiple differentiation states underlie CMML disease progression. These states are negatively augmented by inflammation and positively affected by hypomethylating agents. Furthermore, we identify HSC depletion and expansion of GMP-like cells with increased cytokine receptor diversity as a feature of myeloblast expansion in inflammatory chronic myeloid neoplasms.

This article is highlighted in the In This Issue feature, p. 476