bluuebunny/crossref_metadata_2025 huggingface dataset:
Demonstration of Pronghorn’s Subchannel Code Modeling of Liquid-Metal Reactors and Validation in Normal Operation Conditions and Blockage Scenarios
Authors: Kyriakopoulos Vasileios , Tano Mauricio E. , Karahan Aydin
Published: March 2023

Pronghorn-SC is a subchannel code within the Multiphysics Object-Oriented Simulation Environment (MOOSE). Initially designed to simulate flows in water-cooled, square lattice, subchannel assemblies, Pronghorn-SC has been expanded to simulate liquid-metal-cooled flows in triangular lattices, hexagonal subchannel assemblies. For this purpose, the algorithm of Pronghorn-SC was adapted to solve the subchannel equations as they are applicable to a hexagonal wire-wrapped sodium-cooled fast reactor. Cheng–Todreas models for pressure drop and cross-flow models were adopted and a coolant heat conduction term was added. To solve these equations, an improved implicit algorithm was developed robust enough to deal with the numerical issues, associated with low flow and recirculation phenomena. To confirm the prediction capability of Pronghorn-SC, calculations and comparisons with available experimental data of 19- and 37-pin assemblies were performed, as well as other subchannel codes. Finally, a flow blockage modeling feature was added. This capability was validated for both water-cooled square sub-assemblies and sodium-cooled hexagonal sub-assemblies, using experimental data of partially and fully blocked cases.
Optimal Insertion of Energy Storage Systems Considering the Economic Dispatch and the Minimization of Energy Not Supplied
Authors: Rengel Andrés , Téllez Alexander Aguila , Ortiz Leony , Ruiz Milton
Published: March 2023

This study presents an optimal insertion model for battery storage systems in the nodes of an electrical transmission network. The proposed model is developed through mixed integer linear programming applied to the calculation of DC power flows, considering restrictions given by the characteristics of the network and by the parameters of the generation units. The proposal’s main objective is to reduce the costs of operation and non-supplied energy produced, due to needing to meet the demand fully or partially. As a case study to evaluate the proposed methodology, the IEEE 24-bar test system is used. In this base case, electrical generators that depend on different primary energy resources are modeled: hydraulic, thermal, photovoltaic, and wind, in addition to potential electrical energy storage systems. These storage systems are assigned as possible analysis scenarios through the proposed optimization technique. The study is carried out in a time horizon of 24 h per day, according to a standard demand curve. With the incorporation of optimally selected storage systems in their capacity and location, it is possible to minimize dependence on the use of fossil fuels. In addition, considerable savings are obtained by reducing generation costs, and the stability of the energy supply is guaranteed. This novel proposal presents a methodology that covers all the variables of this problem, thus guaranteeing an authentic and precise study in terms of optimization. The results obtained highlight and demonstrate the benefits of stability, continuous attention to demand, reduction in dependence on exhaustible and polluting sources, and cost reduction.
Conceptual Design of the Steam Generators for the EU DEMO WCLL Reactor
Authors: Tincani Amelia , Ciurluini Cristiano , Nevo Alessandro , Giannetti Fabio , Tarallo Andrea , Tripodo Claudio , Cammi Antonio , Vannoni Alessandra , Eboli Marica , Del Moro Tommaso , Lorusso Pierdomenico , Barucca Luciana
Published: March 2023

In the framework of the EUROfusion Horizon Europe Programme, ENEA and its linked third parties are in charge of the conceptual design of the steam generators belonging to EU DEMO WCLL Breeding Blanket Primary Heat Transfer Systems (BB PHTSs). In particular, in 2021, design activities and supporting numerical simulations were carried out in order to achieve a feasible and robust preliminary concept design of the Once Through Steam Generators (OTSGs), selected as reference technology for the DEMO Balance of Plant at the end of the Horizon 2020 Programme. The design of these components is very challenging. In fact, the steam generators have to deliver the thermal power removed from the two principal blanket subsystems, i.e., the First Wall (FW) and the Breeding Zone (BZ), to the Power Conversion System (PCS) for its conversion into electricity, operating under plasma pulsed regime and staying in dwell period at a very low power level (decay power). Consequently, the OTSG stability and control represent a key point for these systems’ operability and the success of a DEMO BoP configuration with direct coupling between the BB PHTS and the PCS. In this paper, the authors reported and critically discussed the FW and BZ steam generators’ thermal-hydraulic and mechanical design, the developed 3D CAD models, as well as the main results of the stability analyses and the control strategy to be adopted.
Electric Hybrid Powertrain for Armored Vehicles
Authors: Piancastelli Luca , Toccaceli Marco , Sali Merve , Leon-Cardenas Christian , Pezzuti Eugenio
Published: March 2023

The performance of modern, new generation-armored vehicles would greatly benefit from overall engineering, optimization, and integration techniques of advanced diesel engines-electrified transmissions. Modern axial flux electric motors and controllers are perfectly able to replace the classical automatic gearbox and complex steering system of traditional Main Battle Tanks. This study shows a possible design of a serial hybrid electric power pack for very heavy tanks with a weight well over 50 tons. The result is a hybrid power system that improves the overall performance of armored vehicles off-road and on-road, improving the acceleration and the smoothness of the ride. In addition, fuel consumption will be reduced because the internal combustion engine operates at fixed rpm. The electric motors will outperform the traditional engines due to their very high torque output even at “zero speed”. The weight of a hybrid system has also been calculated. In fact, in many cases, it is possible to use all off-the-shelf components. The on-board diagnosis of the subsystems in the hybrid powertrain makes it possible to achieve a Time Between Overhaul (TBO) of 4500 h with a failure probability inferior to one in 10,000.
Parameter Identification of DFIG Converter Control System Based on WOA
Authors: Li Youtao , Zeng Yun , Qian Jing , Yang Fanjie , Xie Shihao
Published: March 2023

The converter is an important component of a wind turbine, and its control system has a significant impact on the dynamic output characteristics of the wind turbine. For the double-fed induction generator (DFIG) converter, the control parameter identification method is proposed. In this paper, a detailed dynamic model of DFIG with the converter is built, and the trajectory sensitivity method is used to study the observation points that are sensitive to the change of control parameters as the observation quantity for control parameter identification; the Whale Optimization Algorithm (WOA) is used to study the converter control system parameters that dominate the output characteristics of DFIG in the dynamic full-process simulation. To validate the proposed method, four classical test functions are used to verify the effectiveness of the algorithm, and the control parameters are identified by setting a three-phase grounded short-circuit fault under maximum power point tracking (MPPT), and the identification results are compared with particle swarm optimization (PSO) and chaotic particle swarm optimization (CPSO) to show the superiority of the proposed method. The final results show that the proposed WOA can identify the control system parameters faster and more accurately.
The Impact of COVID-19 Regulations on Adherence to Recombinant Human Growth Hormone Therapy: Evidence from Real-World Data
Authors: van Dommelen Paula , Baños Rosa Maria , Arnaud Lilian , Le Masne Quentin , Koledova Ekaterina
Published: March 2023

Worldwide regulations during COVID-19 positively and negatively impacted self-management in paediatric patients with chronic medical conditions. We investigated the impact of regulations on adherence to recombinant human growth hormone (r-hGH) therapy in paediatric patients with growth disorders, using real-world adherence data extracted March 2019–February 2020 (before COVID-19) and March 2020–February 2021 (during COVID-19) from the easypod™ connect ecosystem. Data from three measures of regulations were analysed: stringency index (SI), school closure and stay-at-home. The mean SI, and the proportion of days with required school closure or stay-at-home during COVID-19 were categorised as high versus medium/low based on the 75th percentile. Adherence was categorised as optimal (≥85%) versus suboptimal (<85%). Adherence data were available for 8915 patients before and 7606 patients during COVID-19. A high SI (mean ≥68) and a high proportion of required school closure (≥88%) resulted in an increase in the proportion of optimal adherence during COVID-19 versus pre-COVID-19 (p < 0.001). Stay-at-home requirements showed no statistically significant effect (p = 0.13). Stringent COVID-19 regulations resulted in improved adherence to r-hGH therapy in patients with growth disorders, supported by connected digital health technologies. Insights into patient behavior during this time are useful to understand potential influences and strategies to improve long-term adherence to r-hGH.
The Effects of Monthly Rainfall and Temperature on Flowering and Fruiting Intensities Vary within and among Selected Woody Species in Northwestern Ethiopia
Authors: Dagnachew Sinework , Teketay Demel , Demissew Sebsebe , Awas Tesfaye , Lemessa Debissa
Published: March 2023

The phenological responses of plants to climatic variables are critical for conservation planning; however, it is less understood in an Afrotropical context. Here, we observed how flowering and fruiting phenophases of seven indigenous plant species are related to monthly rainfall and temperature for 24 months in Ethiopia. We employed linear and non-linear models to test the effects on flowering and fruiting intensity. The results of the linear model showed that flowering intensity decreased with increasing monthly temperature for Maytenus arbutifolia, Prunus africana, and Solanecio gigas, but increased for Bersama abyssinica, and decreased with increasing monthly rainfall for Maytenus arbutifolia. The results of the non-linear model indicated that the flowering intensity of Brucea antidysenterica, Dombeya torrida and Rosa abyssinica decreased, leveled off and increased with increasing monthly temperature. Moreover, the fruiting intensity of Brucea antidysenterica and Rosa abyssinica decreased with increasing monthly rainfall, but increased for Bersama abyssinica; The fruiting intensity increased with increasing monthly temperature for Brucea antidysenterica and Rosa abyssinica. Altogether, the effects of climatic variables not only vary among the species, but also among the phenophases of a plant species. Hence, considering these varied effects in forest conservation schemes is critical, especially during the epoch of this continuing climate change.
Forests Attenuate Temperature and Air Pollution Discomfort in Montane Tourist Areas
Authors: Gottardini Elena , Cristofolini Fabiana , Cristofori Antonella , Ferretti Marco
Published: March 2023

Forests deliver many ecosystem services, from provisioning to regulating and cultural services. We aimed at demonstrating microclimatic regulation and pollutant removal as especially relevant ecosystem services when considering the tourism vocation of the Alpine regions. A study was realized along an altitudinal gradient (900–1600 m a.s.l.) in Trentino, northern Italy, an area with high touristic presence (ca. 9.3 million overnight stays in summer 2021). Nitrogen dioxide (NO2, µg m−3), ozone (O3, µg m−3) concentrations, air temperature (T, °C), and relative humidity (RH, %) were simultaneously measured in three open-field sites (OF) and below-canopy Norway spruce forest stands (FO) during the period 23 May–7 August 2013. The temperature–humidity index (THI) was calculated. We found a distinct mitigating effect of forest on T, with lower maximum (−30.6%) and higher minimum values (+6.3%) in FO than in OF. THI supported a higher comfort sensation in FO than in OF, especially in the central part of the day. NO2 concentrations did not differ between OF and FO; ozone concentrations were lower in FO than OF. This study confirms the role of forests in providing several ecosystem services beneficial for forest users, especially relevant for promoting nature-based tourism in the Alpine region.
AMDNet: A Modern UAV RGB Remote-Sensing Tree Species Image Segmentation Model Based on Dual-Attention Residual and Structure Re-Parameterization
Authors: Huang Haozhe , Li Feiyi , Fan Pengcheng , Chen Mingwei , Yang Xiao , Lu Ming , Sheng Xiling , Pu Haibo , Zhu Peng
Published: March 2023

Tree species classification is an important and challenging task in image recognition and the management of forest resources. Moreover, the task of tree species classification based on remote sensing images can significantly improve the efficiency of the tree species survey and save costs. In recent years, many large models have achieved high accuracy in the task of tree species classification in an airborne remote-sensing manner, but due to their fixed geometric structure, traditional convolutional neural networks are inherently limited to the local receptive field and can only provide segmental context information. The limitation of insufficient context information greatly affects the segmentation accuracy. In this paper, a dual-attention residual network (AMDNet) and a re-parameterized model approach are proposed to capture the global context information, fuse the weight, reduce the model volume, and maintain the computational efficiency. Firstly, we propose MobileNetV2 as the backbone network for feature extraction to further improve the feature identification by modeling semantic dependencies in the spatial dimension and channel dimension and adding the output of the two attention modules. Then, the attention perception features are generated by stacking the attention modules, and the in-depth residual attention network is trained using attention residual learning, through which more accurate segmentation results can be obtained. Secondly, we adopt the approach of structure re-parameterization, use a multi-branch topology for training, carry out weighted averaging on multiple trained models, and fuse multiple branch modules into a completely equivalent module in inference. The proposed approach results in a reduction in the number of parameters and an accelerated inference speed while also achieving improved classification accuracy. In addition, the model training strategy is optimized based on Transformer to enhance the accuracy of segmentation. The model was used to conduct classification experiments on aerial orthophotos of Hongya Forest Farm in Sichuan, China, and the MIOU of tree species recognition using the test equipment reached 93.8%. Compared with current models such as UNet, our model exhibits a better performance in terms of both speed and accuracy, in addition to its enhanced deployment capacity, and its speed advantage is more conducive to real-time segmentation, thereby representing a novel approach for the classification of tree species in remote sensing imagery with significant potential for practical applications.
Effects of Different Beer Compounds on Biometrically Assessed Emotional Responses in Consumers
Authors: Gonzalez Viejo Claudia , Hernandez-Brenes Carmen , Villarreal-Lara Raul , De Anda-Lobo Irma C. , Ramos-Parra Perla A. , Perez-Carrillo Esther , Clorio-Carrillo Jorge A. , Tongson Eden , Fuentes Sigfredo
Published: March 2023

The study of emotional responses from consumers toward beer products is an important digital tool to obtain novel information about the acceptability of beers and their optimal physicochemical composition. This research proposed the use of biometrics to assess emotional responses from Mexican beer consumers while tasting top- and bottom-fermented samples. Furthermore, a novel emotional validation assessment using proven evoking images for neutral, negative, and positive emotions was proposed. The results showed that emotional responses obtained from self-reported emoticons and biometrics are correlated to the specific emotions evoked by the visual, aroma, and taste aspects of beers. Consumers preferred bottom-fermentation beers and disliked the wheat-based and higher-bitterness samples. Chemical compounds and concentrations were in accordance to previously reported research for similar beer styles. However, the levels of hordenine were not high enough to evoke positive emotions in the biometric assessment, which opens additional research opportunities to assess higher concentrations of this alkaloid to increase the happiness perception of low or non-alcoholic beers.
Consumer Intention to Utilize an E-Commerce Platform for Imperfect Vegetables Based on Health-Consciousness
Authors: Naruetharadhol Phaninee , Wongsaichia Sasichakorn , Pienwisetkaew Teerapong , Schrank Johannes , Chaiwongjarat Kullanan , Thippawong Peeranut , Khotsombat Thanaphat , Ketkaew Chavis
Published: March 2023

Thailand has a problem with fruit and vegetable waste because consumers have a negative attitude towards fruit and vegetables with imperfect shapes; however, those imperfections have no impact on nutritional quality. Young adults are most aware of the problem of food waste. Here, we study factors influencing consumer’ intention to adopt an e-commerce platform that commercializes imperfect vegetables (ugly veggies). In all, 390 respondents from four provinces of Thailand were enrolled in the study. Cluster analysis, structural equation modeling, and multigroup moderation analysis approaches were used. The main conceptual framework was adapted from the unified theory of acceptance and the use of technology. Respondents were classified into low, moderate, and high health-conscious segments. We found that performance expectancy positively influences the behavioral intention of highly health-conscious consumers. For consumers in the moderate health-consciousness segment, effort expectancy and social influence positively affect behavioral intention. None of the hypothesized factors influence the low health-consciousness segment’s behavioral intention. This paper expands the understanding of consumer’ attitudes toward accepting an imperfect vegetable e-commerce platform. Additionally, the research can guide platform development and marketing efforts.
HetroTraffSim: A Macroscopic Heterogeneous Traffic Flow Simulator for Road Bottlenecks
Authors: Zeb Ali , Khattak Khurram S. , Rehmat Ullah Muhammad , Khan Zawar H. , Gulliver Thomas Aaron
Published: March 2023

Smart mobility is crucial for future smart cities. Traffic simulation software (TSS) is an important tool for efficient planning and management of road networks to achieve this goal. Many TSS tools have been developed for both microscopic and macroscopic homogenous traffic flow. However, only two (SUMO and HetroSim) are applicable to heterogeneous traffic. In this paper, HetroTraffSim is proposed to simulate macroscopic heterogeneous traffic flows at road bottlenecks. It is developed using the Unity3D engine and is based on a second-order traffic flow model. It is evaluated for a 360 m road segment on University Road, Peshawar, Pakistan. This segment contains a 78.5 m bottleneck which causes traffic congestion. This bottleneck is due to the construction of a pedestrian overhead bridge which reduces the three-lane road to two lanes. HetroTraffSim provides normalized traffic velocity, average traffic density, traffic flow, and time, as well as the temporal and spatial evolution of traffic. The results obtained show that a change in the distance headway affects the traffic flow, velocity, and density. Further, HetroTraffSim can be extended to automated traffic flows using raycasting. It can easily be used to create realistic traffic scenarios and the computational complexity is low due to the small-degree polynomials employed. HetroTraffSim can be used by traffic planners to improve traffic flow and public safety.
Permeability-Enhanced Liposomal Emulgel Formulation of 5-Fluorouracil for the Treatment of Skin Cancer
Authors: Pachauri Ankur , Chitme Havagiray , Visht Sharad , Chidrawar Vijay , Mohammed Nawaj , Abdel-Wahab Basel A. , Khateeb Masood Medleri , Habeeb Mohammed Shafiuddin , Orabi Mohamed A. A. , Bakir Marwa B.
Published: March 2023

The plain 5-fluorouracil (5FU) formulations available in the market are associated with adverse effects such as skin irritation, pruritus, redness, blisters, allergy, and dryness on the site of application. The objective of the present study was to develop a liposomal emulgel of 5FU with increased skin permeability and efficacy using clove oil and eucalyptus oil along with pharmaceutically acceptable carriers, excipients, stabilizers, binders, and additives. A series of seven formulations were developed and evaluated for their entrapment efficiency, in vitro release profile, and cumulative drug release profile. The compatibility of drugs and excipients, as confirmed by FTIR (fourier-transform infrared spectroscopy) and DSC (differential scanning calorimetry) as well as SEM (scanning electron microscopy) and TEM (transmission electron microscopy) studies, revealed that the size and shape of liposomes are smooth and spherical, and the liposomes are non-aggregated. To understand their efficacy, the optimized formulations were evaluated for cytotoxicity using B16-F10 mouse skin melanoma cells. The eucalyptus oil and clove oil-containing preparation significantly produced a cytotoxic effect against a melanoma cell line. The addition of clove oil and eucalyptus oil increased the efficacy of the formulation by improving skin permeability and reducing the dose required for the anti-skin cancer activity.
Radioactivity/Radionuclide (U-232 and Am-241) Removal from Waters by Polyurea-Crosslinked Alginate Aerogels in the Sub-Picomolar Concentration Range
Authors: Ioannidis Ioannis , Pashalidis Ioannis , Raptopoulos Grigorios , Paraskevopoulou Patrina
Published: March 2023

The removal of radionuclide/radioactivity from laboratory and environmental water samples under ambient conditions was investigated via batch-type experiments using polyurea-crosslinked calcium alginate (X-alginate) aerogels. Water samples were contaminated with traces of U-232 and Am-241. The removal efficiency of the material depends strongly on the solution pH; it is above 80% for both radionuclides in acidic solutions (pH 4), while it decreases at about 40% for Am-241 and 25% for U-232 in alkaline solutions (pH 9). This is directly associated with the presence of the radionuclide species in each case; the cationic species UO22+ and Am3+ prevail at pH 4, and the anionic species UO2(CO3)34– and Am(CO3)2− prevail at pH 9. Adsorption on X-alginate aerogels is realized by coordination of cationic species on carboxylate groups (replacing Ca2+) or other functional groups, i.e., –NH and/or –OH. In environmental water samples, i.e., ground water, wastewater and seawater, which are alkaline (pH around 8), the removal efficiency for Am-241 is significantly higher (45–60%) compared to that for U-232 (25–30%). The distribution coefficients (Kd) obtained for the sorption of Am-241 and U-232 by X-alginate aerogels are around 105 L/kg, even in environmental water samples, indicating a strong sorption affinity of the aerogel material for the radionuclides. The latter, along with their stability in aqueous environments, make X-alginate aerogels attractive candidates for the treatment of radioactive contaminated waters. To the best of our knowledge, this is the first study on the removal of americium from waters using aerogels and the first investigation of adsorption efficiency of an aerogel material at the sub-picomolar concentration range.
Children of Holocaust Survivors: The Experience of Engaging with a Traumatic Family History
Authors: Krauskopf Irene Esther , Bates Glen William , Cook Roger
Published: March 2023

This study explored the motivation and the experiences of children of Holocaust survivors who were actively engaged with the traumatic histories of their parents. Our findings are consistent with contemporary views of the intergenerational transmission of the effects of trauma to descendants of Holocaust survivors and reflect a mixture of resilience and vulnerabilities. We interviewed 24 siblings from 11 families who were adult children of Holocaust survivors, alongside the experience of the first author (IK), also a child of Holocaust survivors. An interpretative phenomenological analysis of those interviews identified two overarching themes related to the motivation to gather information about their parents’ stories and their experience of seeking this knowledge. Two themes relate to motivation. The first captured a sense of immersion without choice in the family story emanating from extreme loss and grief and a deep awareness of the communal nature of Jewish history. The second theme encompassed a compulsion and desire to leave a meaningful legacy of their parents’ experiences for future generations. These themes were linked to themes capturing the experience of engaging with their parents’ traumatic stories and describing intense ambivalence. One theme reflected a reluctance to gather information detailing the parents’ trauma. Yet, the other theme emphasised positive outcomes derived from knowledge, including appreciation of their parents’ resilience and opportunities to bear witness to and support their ageing parents. Overall, the data reveal the close links between family histories and adjustment to a traumatic past.
High Throughput SARS-CoV-2 Genome Sequencing from 384 Respiratory Samples Using the Illumina COVIDSeq Protocol
Authors: Papa Mze Nasserdine , Kacel Idir , Beye Mamadou , Tola Raphael , Sarr Mariéma , Basco Leonardo , Bogreau Hervé , Colson Philippe , Fournier Pierre-Edouard
Published: March 2023

The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic has fostered the use of high-throughput techniques to sequence the entire severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and track its evolution. The present study proposes a rapid and relatively less expensive sequencing protocol for 384 samples by adapting the use of an Illumina NovaSeq library to an Illumina MiSeq flow cell instrument. The SARS-CoV-2 genome sequences obtained with Illumina NovaSeq and those obtained using MiSeq instruments were compared with the objective to validate the new, modified protocol. A total of 356 (94.6%) samples yielded interpretable sequences using the modified Illumina COVIDSeq protocol, with an average coverage of 91.6%. By comparison, 357 (94.9%) samples yielded interpretable sequences with the standard COVIDSeq protocol, with an average coverage of 95.6%. Our modified COVIDSeq protocol could save 14,155 euros per run and yield results from 384 samples in 53.5 h, compared to four times 55.5 h with the standard Illumina MiSeq protocol. The modified COVIDSeq protocol thus provides high quality results comparable to those obtained with the standard COVIDSeq protocol, four times faster, while saving money.
Optical Genome Mapping Reveals and Characterizes Recurrent Aberrations and New Fusion Genes in Adult ALL
Authors: Vieler Lisa-Marie , Nilius-Eliliwi Verena , Schroers Roland , Vangala Deepak Ben , Nguyen Huu Phuc , Gerding Wanda Maria
Published: March 2023

(1) Background: In acute lymphoblastic leukemia (ALL) the genetic characterization remains challenging. Due to the genetic heterogeneity of mutations in adult patients, only a small proportion of aberrations can be analyzed with standard routine diagnostics. Optical genome mapping (OGM) has recently opened up new possibilities for the characterization of structural variants on a genome-wide level, thus enabling simultaneous analysis for a broad spectrum of genetic aberrations. (2) Methods: 11 adult ALL patients were examined using OGM. (3) Results: Genetic results obtained by karyotyping and FISH were confirmed by OGM for all patients. Karyotype was redefined, and additional genetic information was obtained in 82% (9/11) of samples by OGM, previously not diagnosed by standard of care. Besides gross-structural chromosome rearrangements, e.g., ring chromosome 9 and putative isodicentric chromosome 8q, deletions in CDKN2A/2B were detected in 7/11 patients, defining an approx. 20 kb minimum region of overlap, including an alternative exon 1 of the CDKN2A gene. The results further confirm recurrent ALL aberrations (e.g., PAX5, ETV6, VPREB1, IKZF1). (4) Conclusions: Genome-wide OGM analysis enables a broad genetic characterization in adult ALL patients in one single workup compared to standard clinical testing, facilitating a detailed genetic diagnosis, risk-stratification, and target-directed treatment strategies.
Population-Level Nutritional Well-Being: Nutrition Security and Equitability
Authors: Reid Kaydian S.
Published: March 2023

Nutrition is essential to sustaining the quality of life and a fundamental right of all people [...]
Geo-Environmental Assessment of Tourist Development and Its Impact on Sustainability
Authors: Morante-Carballo Fernando , Apolo-Masache Boris , Taranto-Moreira Fred , Merchán-Sanmartín Bethy , Soto-Navarrete Lady , Herrera-Franco Gricelda , Carrión-Mero Paúl
Published: March 2023

The evaluation of geosites is an essential part of conserving the geodiversity and biodiversity of an ecosystem, as well as safeguarding the cultural, geological, environmental, and landscape wealth that a highly recognized geographical area possesses. In this context, Guayaquil, the pearl of the Pacific, is a city that registers, in its history and evolution, a binding relationship with the geo-biodiversity of the geosites that characterize it. This work aims to assess places of tourist interest in Guayaquil and its surrounding areas through a geo-environmental evaluation matrix to establish a sustainability proposal that promotes the geotourism development of the city. The methodology consisted of: (i) geographic registration of the chosen sites and present characteristics, (ii) environmental analysis of the sites based on the cause–effect method, and (iii) strategies for the inclusion of these sites into the geo-environmental and geotourism system of Guayaquil as potential geosites. The results demonstrate that Guayaquil has impressive geodiversity in several potential natural sites, obtaining highly representative values that reinforce the city’s natural diversity elements. Sites such as Cerro San Pedro and the Cerro San Eduardo, Pascuales, and Zeolites quarries have the most significant adverse environmental impacts. While places such as Cerro Azul, Estero Salado, Isla Santay, and Hornos de Cal (Bosque Protector Cerro Blanco), obtained positive values that highlight their environmental value, being of great benefit to the city and to nature. Furthermore, some of these places could be integrated into tourism development plans, and as potential geosites, they could complement various services and opportunities for discovering nature. Finally, all this can lead to a sustainable proposal for a Global Geopark project in Guayaquil based on the results obtained in this work.
Bibliometric Mapping of School Garden Studies: A Thematic Trends Analysis
Authors: Castillo Dante , Vega-Muñoz Alejandro , Salazar-Sepúlveda Guido , Contreras-Barraza Nicolás , Torres-Alcayaga Mario
Published: March 2023

This paper analyzes the thematic trends in school garden studies over the past few decades, using a relational bibliometric methodology on a corpus of 392 articles and review articles indexed in the Web of Science Core Collection. The paper seeks to understand how researchers have studied the concept over the last few decades in various disciplines, spanning approximately eighty Web of Science categories. The results show that there is a critical mass of scientific research studying school gardens. The analysis shows the thematic trends in discussion journals, discussion terminology, and consolidates classic papers and some novel authors and papers. The studies and their theoretical trends lead to refocusing the analysis on the effects of school gardens beyond the educational, thanks to the contribution of authors from more than fifty countries engaged in the study of these activities. This work constitutes new challenges for this line of research, raising interdisciplinary research challenges between horticultural, environmental, technological, educational, social, food, nutritional, and health sciences.
Facilitators and Barriers to a Hospital-Based Communication Skills Training Programme: An Interview Study
Authors: Wolderslund Maiken , Waidtløw Karin , Kofoed Poul-Erik , Ammentorp Jette
Published: March 2023

This study aimed to investigate the facilitators and barriers experienced by the department management (DMs) and communication skills trainers (trainers) during the implementation of a 3-day communication skills training (CST) programme for healthcare professionals (HCPs). Thus, we conducted semi-structured interviews with 23 DMs and 10 trainers from 11 departments concurrently implementing the CST programme. Thematic analysis was undertaken to elucidate the themes across the interviews. Five themes were developed: resource consumption; obstacles; management support; efforts and outcomes; and a lack of systematic follow-up. Although the DMs and trainers were largely in agreement, the theme of a lack of systematic follow-up was derived exclusively from the trainers, as were two of the subthemes within obstacles: (b) seniority, profession, and cultural differences, and (c) the trainers’ competencies. The greatest perceived barrier was resource consumption. In addition, DMs found planning and staff resistance to be a challenge. However, the HCPs’ resistance diminished or even changed to satisfaction after participating. The mandatory approach served as both a facilitator and a barrier; DMs’ support was an essential facilitator. Explicit communication related to resource demands, planning, and participation is crucial, as is management support and the allocation of resources.
Opinions Related to the Potential Application of Artificial Intelligence (AI) by the Responsible in Charge of the Administrative Management Related to the Logistics and Supply Chain of Medical Stock in Health Centers in North of Chile
Authors: Bas Tomas Gabriel , Astudillo Paula , Rojo Daniel , Trigo Angel
Published: March 2023

The research evaluated the opinion of those in charge of the administrative management of the logistics and supply chain of medical and pharmaceutical stocks of health care centers in the north of Chile and a potential improvement of their operations through the use of artificial intelligence (AI). The identification of the problem arose from the empirical analysis, where serious deficiencies in the manual handling and management of the stock of medicines and hospital supplies were evidenced. This deficiency does not allow a timely response to the demand of the logistics and supply chain, causing stock ruptures in health centers. Based on this finding, we asked ourselves how AI was observed as the most efficient tool to solve this difficulty. The results were obtained through surveys of personnel in charge of hospital and pharmacy supplies. The questions focused on the level of training, seniority in positions related to the problem, knowledge of regulations, degree of innovation in the procedures used in logistics and supply chain and procurement. However, a very striking fact was related to the importance of the use of AI, where, very surprisingly, 64.7% considered that it would not help to reduce human errors generated in the areas analyzed.
Living through a Global Pandemic: A Cross-Sectional Study on the Psychological Resilience of the University Population in Iran
Authors: Ahmadi Fereshteh , Cetrez Önver Andreas , Zandi Saeid
Published: March 2023

Aims: This study aimed to describe and understand the individual and social dimensions of resiliency among Iranian academics as professionals during the early wave of the ongoing pandemic. Furthermore, we aimed to emphasize the cultural context in our analysis. Method: A cross-sectional survey design was adopted. We used convenient sampling, administered through an online survey, among academics at Iranian universities (n = 196, 75% women). We employed the CD-RISC 2 instrument, items on life meaning, and a modified version of Pargament’s RCOPE instrument (Meaning, Control, Comfort/Spirituality, Intimacy/Spirituality, and Life Transformation). Results: The results revealed a strong level of resilience among men (M = 5.78) and women (M = 5.52). Self-rated health was rated as excellent, very good, or good among a majority (92%) of the participants, more so among men. Family was one of the factors that most strongly gave life meaning, followed by friends, work/school, and religion/spirituality. There was a strong correlation between self-rated health and life as part of a greater whole, being alone, and listening to the sounds of the surrounding nature. Conclusions: Both personal and social levels of resilience and meaning-making are seen in the results, with an ability to balance between obstacles and resources. Cultural practices are interdependent, which also include the individual and social dimensions of resiliency and meaning-making.
Spatiotemporal Characteristics of the Coupled Coordination Degree of Ecosystem Services Supply and Demand in Chinese National Nature Reserves
Authors: Huang Cheng , Zeng Jie , Chen Wanxu , Cui Xinyu
Published: March 2023

Nature reserves (NRs) are the main components of protected areas and geographic spaces, with unique natural and cultural resources. The establishment of nature reserves has not only strengthened the protection of specific species but has also played a vital role in the protection of ecosystem services (ESs). However, few studies have been conducted to systematically assess the effectiveness of nature reserves from the perspective of ecosystem services supply and demand (S&D) or make comparisons between the conservation effects of different types of nature reserves. This study analyzed the spatiotemporal characteristics of ecosystem service supply and demand in 412 Chinese national nature reserves. The results showed that both supply and demand for ecosystem services per unit area show a spatial pattern of increasing from west to east. The supply–demand matching pattern is dominated by high supply–high demand (H–H) and low supply–high demand (L–H) in the central and eastern regions, and high supply–low demand (H–L) and low supply–low demand (L–L) in the northeast, northwest, and southwest regions. The coupling coordination degree (CCD) of ecosystem services supply and demand increased from 0.53 in 2000 to 0.57 in 2020, and the number of NRs reaching the coordinated level (>0.5) increased by 15 from 2000 to 2020, representing 3.64% of the total number of protected areas. Steppe meadows, ocean coasts, forest ecosystems, wildlife, and wild plant types of nature reserves all improved more obviously. This provides a scientific basis for strengthening the ecological and environmental supervision of nature reserves, and the research methods and ideas can provide references for similar research.
Sustainability of Leisure Tourism Events from a Destination Social Responsibility Perspective: Do Attribution Theory Dimensions Matter?
Authors: Maki Zakya E. Y. , Hassan Thowayeb H. , Helal Mohamed Y. , Saleh Mahmoud I.
Published: March 2023

Although Destination Sustainable Responsibility (DSR) has become a critical factor in upholding tourists’ satisfaction and positive behavioral outcomes, research on how tourists perceive different attributional dimensions (e.g., controllability, stability) about the existing information adequacy on tourists’ behavior is limited. Additionally, no study has investigated how DSR influences leisure tourists’ satisfaction across various characteristics. Therefore, the current research has the novelty of examining the effects of Destination Sustainable Responsibility (DSR) on leisure tourists’ satisfaction. The study reveals two attribution theory dimensions, controllability, and stability, as mediators and information adequacy as a moderated mediation. Additionally, the study investigates how tourists’ personalities (extroverted, conscientious, neurotic, open, and agreeable) affect their perceptions of attribution dimensions. A quantitative analysis of 464 tourists who experienced leisure activities in sustainability resorts in the Red Sea was conducted to explore these relationships. The results provide a better understanding of how DSR affects leisure tourists’ satisfaction and how different personalities influence their perceptions. Our research findings demonstrate that tourists’ perceptions of destination sustainability initiatives (DSR) are contingent upon the controllability and stability of events and that extraverted and conscientious tourists reach different attributions on DSR than those with neuroticism and openness levels and agreeableness. Additionally, it appears that information adequacy concerning the controllability of events is privileged over the event’s stability about informant amount with DSR. We explore the implications of our conclusions from both theoretical and management perspectives.
Salivary Alterations in Autoimmune Thyroid Diseases: A Systematic Review
Authors: Ortarzewska Martyna , Nijakowski Kacper , Kolasińska Julia , Gruszczyński Dawid , Ruchała Marek A. , Lehmann Anna , Surdacka Anna
Published: March 2023

Autoimmune thyroid disease (AITD) is a dysregulation of the immune system that causes an attack on the thyroid gland. Two major clinical manifestations are Hashimoto’s thyroiditis and Graves’ disease. Saliva performs many functions and, importantly, has the potential for easy, non-invasive diagnostics of several systemic disorders. This systematic review was designed to answer the question whether salivary alterations are reliable for the diagnosis of autoimmune thyroid diseases. Following the inclusion and exclusion criteria, fifteen studies were included. Due to their heterogeneity, saliva analysis was divided into two subgroups: quantitative assessment analysing salivation and qualitative assessment concerning potential salivary biomarkers for AITD. In addition to detecting altered levels of thyroid hormones and antibodies, salivary changes were also observed in the concentrations of total protein, cytokines and chemokines, as well as markers of oxidative status. According to the saliva flow rate values, significantly reduced saliva secretion was observed in patients with HT. In conclusion, it is not possible to unequivocally state if salivary biomarkers can potentially be used in autoimmune thyroid disease diagnosis. Therefore, further investigations, including salivation disorders, are necessary to validate these findings.
The Impact of Service Learning on Academic, Professional and Physical Wellbeing Competences of EFL Teacher Education Students
Authors: Hooli Eeva-Maria , Corral-Robles Silvia , Ortega-Martín José Luis , Baena-Extremera Antonio , Ruiz-Montero Pedro Jesús
Published: March 2023

In response to the challenges of the 21st century, the European Higher Education Area (EHEA) has been committed to the development of a training model that focuses on the acquisition of cognitive, physical, and social competences, among others, rather than the mere acquisition of knowledge. This approach has gained momentum in recent years, where the learners are the protagonists of their own learning process. This change of approach requires a change in methodology and involves a renewal of the methodological approach in Spanish universities. Service learning (S-L) is an active methodology that is gaining ground across universities due to its experiential, community-based and reflective characteristics. The present study aimed to provide an overview of the impact of S-L by active programs (physical activities, movement games, active tasks, etc.) on the acquisition of professional, linguistic, pedagogical or intercultural competencies, as well as physical wellbeing skills, on English as a foreign language (EFL) teacher education students. Fourteen Spanish EFL university students carried out an S-L active intervention with a migrant group from the Migrant Temporary Stay Centre in the autonomous city of Melilla (Spain). A qualitative study was designed to evaluate the achievement of these competencies. The results show that even though S-L is a challenging methodology, it favours the development of academic, professional, and physical wellbeing competences to succeed in a competitive and changing world, as well as the improvement of the participant students.
Social Isolation and Social Support Influence Health Service Utilisation and Survival after a Cardiovascular Disease Event: A Systematic Review
Authors: Freak-Poli Rosanne , Hu Jessie , Phyo Aung Zaw Zaw , Barker S. Fiona
Published: March 2023

Both cardiovascular disease (CVD) and social health carry high health and economic burdens. We undertook a systematic review to investigate the association between social isolation, low social support, and loneliness with health service utilisation and survival after a CVD event among people living in Australia and New Zealand. Four electronic databases were systematically searched for the period before June 2020. Two reviewers undertook the title/abstract screen. One reviewer undertook a full-text screen and data extraction. A second author checked data extraction. Of 756 records, 25 papers met our inclusion criteria. Included studies recruited 10–12,821 participants, aged 18–98 years, and the majority were males. Greater social support was consistently associated with better outcomes on four of the five themes (discharge destination, outpatient rehabilitation attendance, rehospitalisation and survival outcomes; no papers assessed the length of inpatient stay). Positive social health was consistently associated with better discharge designation to higher independent living. As partner status and living status did not align with social isolation and social support findings in this review, we recommend they not be used as social health proxies. Our systematic review demonstrates that social health is considered in cardiac care decisions and plays a role in how healthcare is being delivered (i.e., outpatient, rehabilitation, or nursing home). This likely contributes to our finding that lower social support is associated with high-intensity healthcare services, lower outpatient rehabilitation attendance, greater rehospitalisation and poorer survival. Given our evidence, the first step to improve cardiac outcomes is acknowledging that social health is part of the decision-making process. Incorporating a formal assessment of social support into healthcare management plans will likely improve cardiac outcomes and survival. Further research is required to assess if support person/s need to engage in the risk reduction behaviours themselves for outpatient rehabilitation to be effective. Further synthesis of the impact of social isolation and loneliness on health service utilisation and survival after a CVD event is required.