bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Characterization and Photophysical Properties of 2-Quinolone-Based Compounds
Authors: Savran Tahir
Published: April 2024

2-Quinolone (1,2-dihydroquinoline) and 1-aza coumarin derivatives are quinoline class pharmacophore structures known for their versatile bioactive and stable photophysical properties. In the present study, N-amino (2) and N-acetamido (3) derivatives of 2-quinolone-based 1-aza Coumarin-3-carboxylic acid were synthesized. Structure characterizations of the synthesized compounds were performed using 1H NMR, IR, 13C NMR spectral techniques. The synthesized compounds are thought to be precursor structures for the development of new bioactive agents because of their structural similarity. The photophysical sensitivities of compounds (2 and 3), which have the 1-Aza coumarin skeleton, in different solvents were examined by ultraviolet−visible (UV−Vis) absorption spectroscopy and fluorescence spectroscopy methods. In addition, the compounds synthesized in this study could serve as fluorophores, fluorescently active and bioactive new Schiff base sensors in different fluorescence studies.
Economic burden assessment for the management of asthma patients at Mexico’s National Institute for Respiratory Diseases
Authors: Cano Salas Maria del Carmen , Miguel Reyes José Luis , Sánchez Trejo Karen , López Estrada Erika del Carmen , Salas Hernández Jorge , Arroyo Rojas Monserrat Evelia , Castañeda Valdivia Mauricio , Escobar Preciado Monserrat , Guzmán Vázquez Silvia , García-García Sergio Ricardo , Soto Molina Herman
Published: April 2024

Background. In Mexico, asthma is one of the top twenty causes of disease with 254,713 new cases reported in 2019. According to Phase 3 of the International Study of Asthma and Allergies in Childhood, the prevalence of asthma ranged from 5 to 14% in 6 Mexican cities with varied geographic conditions. The burden of this disease impacts the health system in terms of direct costs through increased hospitalization and treatment costs; and indirect costs such as school and work absenteeism. Methods. A retrospective, longitudinal observational study comprised by data from 247 female asthma patients, annual direct costs were estimated including: visits, laboratory tests, pharmacological treatment and management of crisis or exacerbations, to determine the annal burden of the disease from an institutional perspective and according to Global Initiative for Asthma classification. Results. The average annual cost was $43,813.92, which increased in relation to the need of inhaled corticosteroids and long-acting beta agonists dosage increase. The average doctor’s appointment cost was $2,004.57, $982.82  for crisis management and $2,645.95 for laboratory testing. Pharmacological treatment represented the main economic burden with an annual average cost of $38,180.58. Conclusions. The present analysis shows the severity of asthma and auxiliary treatments like biologics were the main factors that increased direct attention costs. The results highlight a high economic burden for asthma within the context of the third level of care in Mexico’s public health system.
Ebû Reşîd en-Nisâbûrî’nin Mu‘tezile Mezhebindeki Yeri ve Ekol İçerisindeki Polemiklere Yaklaşımı
Authors: Yilmaz Edip , İşcan Mehmet Zeki
Published: April 2024

Çalışmamızda geç dönem Mu‘tezilesinin önemli temsilcilerinden birisi olan Ebû Reşîd en-Nîsâbûrî’nin Mu‘tezile mezhebindeki konumunu ve ekol içerisindeki polemiklere yaklaşımını ele aldık. Kâdî
Abdülcebbâr’ın önde gelen talebelerinden birisi olan Nisâbûrî, hocasının vefatından sonra Basra Mu‘tezilesinin riyasetini üstlenmiştir. Kaynaklarda hayatına dair fazla bilgi bulunmasa da ömrünün ilk yıllarında Bağdat Mu‘tezilesine mensup olduğu ve Horasan bölgesinde büyük bir üne sahip olan Ebü’l-Kâsım el-Belhî’nin görüşlerinden etkilendiği aktarılmaktadır. Günümüze ulaşan ve Basra Mu‘tezilesinin bakış açısıyla kaleme alınan eserlerinde Belhî’nin görüşlerine yoğun bir şekilde atıfta bulunmaya devam etmektedir. Ömrünün ilk yıllarında Bağdat ekolüne mensup olması ve daha sonra Basra ekolüne intisap etmesi, kendisine her iki ekolü yakından tanıma fırsatı sunmuştur. Bu tecrübesinden hareketle iki ekol arasındaki polemiklere dair bir eser telif etmiş ve eserde Ebû Hâşim el-Cübbâî’nin görüşlerini Bağdat Mu‘tezilesine karşı savunmuştur. Nîsâbûrî’nin görüşlerini yakından incelediğimiz zaman Mu‘tezile içerisinde Şiî temâyüllerin başladığı Büveyhiler döneminde yaşamasına rağmen Mu‘tezilî bakış açısını büyük oranda muhafaza ettiğini söyleyebiliriz. Farklı fikirler ve yaklaşımlar ileri sürmekten ziyade hocasının yolunu takip ederek Mu‘tezilî mirası daha sistematik ve anlaşılır bir hale getirmeye çalışmıştır. Ayrıca kendine özgü birtakım yaklaşımlar da ileri sürmüştür. Özellikle sarfe konusunda Nazzâm gibi ilk dönem Mu‘tezilî düşünürlere ciddi eleştiriler yönelterek genel sünnî görüşe yakın bir tutum sergilemiştir. Şehristânî’nin de ifade ettiği üzere Basra Mu‘tezilesinin sünnî düşünceye bu yakın konumlanışını Nîsâbûrî’nin nübüvvet ve keramet konularında da görmek mümkündür. Çalışmamızda dokümantasyon tekniği kullanılarak Nîsâbûrî’nin hem yazma hem de matbu olarak günümüze ulaşan eserleri tespit edilmiştir. Bu eserler içerik analizine tabi tutularak incelenmiş ve ulaşılan sonuçlar değerlendirilmiştir.
The Potential Use of Dimethyltryptamine against Ischemia-reperfusion Injury of the Brain
Authors: Attila Kovacs , Anna Mathe , Ede Frecska
Published: April 2024

Ischemia-Reperfusion Injury (IRI) is the outcome of two intertwined pathological processes resulting from the shortage of blood flow to tissues and the subsequent restoration of circulation to a previously ischemic area. IRI (sometimes just one side of the dyad) remains one of the most challenging problems in several branches of emergency medicine. Mitochondrial and endoplasmic reticulum dysfunction is a crucial pathological factor involved in the development of IRI. The sigma-1 receptor (Sig1-R) is an intracellular chaperone molecule located between the mitochondria and endoplasmic reticulum with an apparent physiological role in regulating signaling between these cell organelles and serves as a safety mechanism against cellular stress. Therefore, amelioration of IRI is reasonably expected by the activation of the Sig1-R chaperone. Indeed, under cellular stress, Sig1-R agonists improve mitochondrial respiration and optimize endoplasmic reticulum function by sustaining high-energy phosphate synthesis. The discovery that N, N-dimethyltryptamine (DMT) is an endogenous agonist of the Sig1-R may shed light on yet undiscovered physiological mechanisms and therapeutic potentials of this controversial hallucinogenic compound. In this article, the authors briefly overview the function of Sig1-R in cellular bioenergetics with a focus on the processes involved in IRI and summarize the results of their in vitro and in vivo DMT studies aiming at mitigating IRI. The authors conclude that the effect of DMT may involve a universal role in cellular protective mechanisms suggesting therapeutic potentials against different components and types of IRIs emerging in local and generalized brain ischemia after stroke or cardiac arrest.
Stories from the “Pressure Cooker”: U.S. Women Navigating Motherhood and Work During the COVID-19 Pandemic
Authors: Happel-Parkins Alison , Azim Katharina , Neal Mary , Barnes Keishana , Gnanadass Edith
Published: April 2024

The COVID-19 pandemic has highlighted and exacerbated the difficult juggling act women in the U.S. have to do between parenting their children and working outside the home. The pandemic has also led to a decline in maternal mental health, particularly among mothers with young children, mothers of color, and those with previous mental health issues. The authors noted these experiences in their own lives as mothers with children and observed them in the lives of the women around them. These observations informed the design of this narrative inquiry study, in which we used semi-structured interviews to explore mothers’ shifting ideas and experiences of mothering, work, and family life during a global pandemic. We used creative analytic practice (CAP) to compose reflexive researcher conversations around the interview data that enabled us to highlight nuances in the data, show more transparently our meaning-making, make visible our researcher subjectivities, show uncertainties about aspects of data interpretation, and create a more accessible data representation.
Evaluation of COSMO-CLM Model Parameter Sensitivity in the Study of Extreme Events across the Eastern Region of India
Authors: Bal Sourabh , Kirchner Ingo
Published: April 2024

The present study aims to identify the parameters from the Consortium for Small-scale Modelling in CLimate Mode (COSMO-CLM) regional climate model that strongly controls the prediction of extreme events over West Bengal and the adjoining areas observed between 2013 to 2018. Metrics, namely Performance Score (PS) screen out the most persuasive parameter on model output. Additionally, the Performance Index (PI) measure the reliability of the model and Skill Score (SS) establishes the model performance against the reference simulation leading to the optimization of the model for a given variable. In this study, parameter screening for four output variables such as 2m-temperature, surface latent heat flux, precipitation and cloud cover of COSMO-CLM is accomplished. For heat wave simulations, 2m-temperature and surface latent heat flux are explored whereas cloud cover and precipitation are examined for extreme rainfall events. A total of 25 adjustable parameters representing the following parameterization schemes: turbulence, land surface process, microphysics, convection, radiation and soil. Out of the six parameterization schemes, the scaling factor of the laminar boundary layer for heat (rlam_heat) and the ratio of laminar scaling factors for heat over sea and land (rat_sea) from the land surface process is sensitive to SLH, TP. The exponent to get the effective surface area (e_surf) from the land surface has a large impact on 2m-temperature. A few parameters from microphysics (cloud ice threshold for auto conversion), convection (mean entrainment rate for shallow convection) and radiation (parameter for computing the amount of cloud cover in saturated conditions) play a significant role in producing TP, and TCC fields. It is evident from the results that the parameter sensitivities on model performance depend on the choice of the meteorological field. Furthermore, in almost all input model parameters, the model performance reveals the opposite character in different domains for a given meteorological field.
RegTech innovations streamlining compliance, reducing costs in the financial sector
Authors: Olufunke Olawale  , Funmilayo Aribidesi Ajayi  , Chioma Ann Udeh  , Opeyemi Abayomi Odejide
Published: April 2024

Regulatory Technology (RegTech) innovations are reshaping the landscape of compliance within the financial sector, presenting opportunities for institutions to enhance efficiency and reduce operational costs. This paper examines the impact of RegTech solutions by focusing on their capacity to streamline compliance processes and mitigate expenses associated with regulatory adherence. Through a qualitative research methodology that includes case studies and expert interviews, the study explores the various dimensions of RegTech applications, ranging from identity verification and risk management to fraud prevention and regulatory reporting. Key findings indicate that RegTech tools leverage advanced technologies such as artificial intelligence, machine learning, and blockchain to automate complex compliance tasks, thereby reducing the need for manual intervention and minimizing human error. These technologies facilitate real-time monitoring and analysis of transactions, which enhances compliance accuracy and operational efficiency. Furthermore, the paper reveals that the adoption of RegTech solutions significantly lowers compliance costs by optimizing resource allocation and reducing the time and labor traditionally required for compliance-related activities. The study concludes that RegTech innovations hold the potential to transform the financial sector's approach to compliance management. By embracing these technologies, financial institutions can not only ensure regulatory compliance more effectively but also achieve considerable cost savings. The paper calls for further research into the long-term impacts of RegTech adoption on the financial industry's regulatory landscape and suggests that regulatory bodies and financial institutions collaborate to foster an environment conducive to RegTech innovation and implementation.
Acute Pain and Analgesia in children
Authors: Maria I. Dalamagka
Published: April 2024

Acute pain is a complex process involving activation of nociceptors, chemical mediators and inflammation. All the major children’s hospitals now have dedicated pain services to provide evaluation and immediate treatment of pain in any child. Children experience pain in a similar way to adults. Pain intensity in children depends on the surgical procedure itself but also on numerous other factors such as age, emotional state or the level of anxiety associated with the hospital stay. The perception and communication of the child’s pain depends on his or her intellectual and social development. Expression of pain therefore relies on the child’s ability to understand, quantitate and communicate it. Previous pain experiences or chronic diseases that required many medical procedures may significantly change the pain threshold in paediatric patients. Moreover, genetic predispositions and environmental effects are significant. The American Academy of Pediatrics and the American Pain Society have reiterated the importance of a multidisciplinary approach in order to eliminate pain in children. In all pediatric settings, an adequate assessment is the initial stage in a proper clinical approach to pain, especially in the emergency departments; therefore, an increasing number of age-related tools have been validated. Systemic opioids, nonsteroidal anti-inflammatory agents and regional analgesics alone or combined with additives are currently used to provide effective postoperative analgesia. These modalities are best utilized when combined as a multimodal approach to treat acute pain in the perioperative setting. The total number of behaviors that are present in the child are used to estimate his/her pain at the time of assessment. Pain assessment is important to facilitate effective postoperative pain management in these vulnerable children. The purpose of this study is to investigate acute pain as well as analgesia and availability of the used analgesic drugs in children. A multimodal approach to preventing and treating pain is usually used.
IOT based water flow meter using ThingSpeak
Authors: Pandimadevi Ganesan  , Thushara Hameed  , Maheswari Maruthakutti
Published: April 2024

The Large scale manufacturing companies are fully automated. Soft Drink Industries and Chemical industries have to constantly measure and quantify the liquids that they are handling during this automation process, and the most common sensor used to measure the flow of a liquid is a Flow Sensor. By using a flow sensor with a microcontroller like NodeMCU, we can calculate the flow rate, and check the volume of liquid that has passed through a pipe, and control it as required. Apart from manufacturing industries, flow sensors can also be found in the agriculture sector, food processing, water management, mining industry, water recycling, coffee machines etc. Further, a water flow sensor will be a good addition to projects like Automatic water dispenser and smart irrigation systems where we need to monitor and control the flow of liquids. In this project, we are going to build a water flow meter using NodeMCU. We will interface the water flow sensor with NodeMCU and LCDI2C, and program it to display the volume of water, which has passed through the valve. For this particular project, we are going to use the YF-S201 water flow sensor, which uses a hall effect to sense the flow rate of the liquid. The measured values are also communicated to the ThingSpeak cloud. The parameters can be monitored remotely form any part of the world. When the volume exceeds the threshold value, Thingspeak will activate the Thingspeak react to send a message to the responsible person with help of the IFTTT applet.
Perception and practice of self-medication by parents on their children: A study carried out in the saint joseph health area of Kisangani (The democratic republic of Congo)
Authors: Jean-Pierre Angali Kashundu  , Benjamin Wale Ndjadi  , Raymond Assani Ramazani
Published: April 2024

Introduction: Self-medication is a major public health problem in view of the risks involved, such as therapeutic failures and the emergence of multi-resistant bacteria. The aim of the study is to demonstrate how self-medication of children is perceived by parents living in the Saint Joseph Health Area, to identify the satisfaction that parents derive from self-medication, to determine the way in which these parents self-medicate their children, and to present what parents can expect from self-medication. Methodology: This was a qualitative, phenomenological study based on free, face-to-face interviews. It concerned 4 mothers found in pre-school consultations at the Saint Joseph Reference Health Centre from June 15 to 30, 2023. Results: With regard to perception, the respondents had demonstrated the significance of self-medication, the determining factors, and their experience on this subject by often resorting to old prescriptions and medicine leaflets. Low income and the time it takes to get to the hospital were the determining factors. The respondents found self-medication satisfying. They were aware of the dangers and risks associated with self-medication. Risk prevention consisted of giving the child palm oil and skimmed milk. Their expectation of self-medicating was always to be cured. Conclusion: Self-medication in Kisangani is a real phenomenon, with the majority of parents practicing it for themselves and their children due to a lack of financial means, as medical care is expensive. Free medical care would be one way of combating this practice.
Implementasi Business Intelligence untuk Visualisasi Laju Indeks Pembangunan Manusia Kota Cirebon Menggunakan Google Collab
Authors: Rozak Bahrul , Febriawan Dimas , Hasan Firman Noor
Published: April 2024

Indeks Pembangunan Manusia (IPM) merupakan ukuran penting untuk mengevaluasi kesejahteraan dan kemajuan suatu wilayah dalam aspek kesehatan, pendidikan, dan ekonomi. Kota Cirebon adalah salah satu wilayah di Indonesia yang memiliki IPM yang terus mengalami perkembangan. Penelitian ini bertujuan untuk menganalisis kemajuan dalam aspek kesehatan, pendidikan, dan ekonomi di Kota Cirebon selama periode tahun 2010 hingga 2020 serta dampak pandemi COVID-19 terhadap IPM. Metodologi yang digunakan melibatkan pengambilan dataset dari data.kotacirebon.go.id, yang mencakup angka harapan hidup, angka harapan lama sekolah, angka rata-rata lama sekolah, dan pengeluaran per kapita per tahun. Analisis dilakukan menggunakan Google Collab untuk visualisasi data yang fleksibel. Hasil analisis menunjukkan kemajuan dalam aspek kesehatan dan pendidikan di Kota Cirebon selama periode tahun 2010 hingga 2020, dengan angka harapan hidup, angka harapan lama sekolah, dan angka rata-rata lama sekolah mengalami peningkatan. Namun, pengeluaran per kapita per tahun mengalami penurunan, yang mungkin terkait dengan dampak pandemi COVID-19. Trend laju IPM Kota Cirebon mengalami peningkatan antara tahun 2010-2019 namun mengalami penurunan pada tahun 2020, hal ini salah satunya terkait dengan dampak pandemi COVID-19. Penelitian ini diharapkan dapat memberikan kontribusi dalam pengembangan visualisasi data untuk memahami perkembangan IPM kota Cirebon dan meningkatkan pemahaman terhadap pentingnya IPM dalam mengukur kemajuan suatu wilayah.
Karakteristik Fisikokimia dan Organoleptik Biskuit Tepung Ubi Jalar Ungu dan Tepung Koro Pedang Putih
Authors: Khafsah Fatya N , Yanti Rini , Manikharda Manikharda
Published: April 2024

Biscuits were made of purple sweet potato flour and jack bean flour as an effort to add nutritional value to the biscuits. This study aimed to determine the effect of different substitution ratios of purple sweet potato flour and jack bean flour on the chemical, physical, and organoleptic characteristics and their benefits as alternative foods for the daily nutritional needs of stunting toddlers. In this study, we used an experimental method with a ration of purple sweet potato flour and jack bean flour. It consisted of four levels treatment P1 (58%:42%); P2 (67%:33%); P3 (75%:25%); and control (100%:0%). The biscuit acceptability test for the four biscuit formulas was carried out using the hedonic test. The selected formula was determined based on the preferences of 70 untrained panelists. Based on the results of the study, it was found that P3 biscuits with the ratio of purple sweet potato flour: jack bean flour (75%: 25%) was the most preferred formula and had a moisture content of 3.41%, ash 2.24%, fat 25.39%, protein 3.94%, carbohydrates 68.42%, total energy 518.03 kcal/100 g; and a hardness value of 12.85 N. The overall acceptance test for P3 biscuits obtained a value of 4.51 (rather like). As a snack, biscuits with the selected formula can meet 9% of protein needs, 26% of fat needs, and 15% of daily carbohydrate needs for toddlers aged 1-3 years and provide energy of 238 kcal/100 g by consuming 14 pieces of biscuits or the equivalent of 46 g of biscuits.
Keanekaragaman Jenis Burung di Pulau Untung Jawa Kepulauan Seribu Provinsi DKI Jakarta
Authors: Kurnia Insan , Rifai Bakhtiar Ahmad , Febriyanti Eka Nur , Kardina Jessi Raisa , Azzahra Rizky Nur Andhini , Satriawan Muhammad Husein
Published: April 2024

Burung merupakan komponen ekosistem yang tersebar luas di berbagai lanskap dan habitat.  Pulau Untung Jawa merupakan bagian dari gugusan Kepulauan Seribu di Teluk Jakarta yang masih memiliki ekosistem alami serta sebagian telah dimodifikasi.  Penelitian ini bertujuan untuk menganalisis keanekaragaman jenis burung di Pulau Untung Jawa.  Penelitian dilaksanakan pada Bulan Juni 2023 di tiga habitat yaitu hutan mangrove, hutan Pantai, serta pemukiman.  Metode yang digunakan yaitu titik hitung selama 5 menit pada pagi hari (06.00-09.00 WIB) dan sore hari (15.00-18.00 WIB). Data dianalisis secara kualitatif maupun kuantitatif mencakup indeks kekayaan jenis Margalef (DMg), indeks keanekaragam jenis shannon-wiener (H’), indeks kemerataan (E), dan indeks kesamaan komunitas (IS).  Jumlah jenis yang dijumpai sebanyak 29 jenis burung dari delapan ordo dan 18 suku.  Terdapat 11 jenis yang memiliki status perlindungan baik menurut Permen LHK RI, Apendiks CITES, maupun Daftar Merah IUCN.  Nilai DMg berkisar antara 4,07-4,96 yang termasuk kategori tinggi.  Nilai H’ berkisar antara 2,96-3,21 yang termasuk kategori tinggi dan sedang.  Sementara nilai E berkisar antara 0,93-0,97 yang termasuk kategori tinggi.  Nilai IS berkisar antara 0,69-0,73 dengan nilaiIS tertinggi antara komunitas burung hutan Pantai dengan komunitas burung pemukiman.
Integrasi Pembelajaran Berbasis Kurikulum Merdeka di Sekolah Dasar Persis
Authors: Pribadi Reksa Adya , Dzambiyah Asfiyatu , Putri Astri Oktaria , Rahmatin Visualy Seyu
Published: April 2024

Penelitian ini bertujuan untuk mendeskripsikan integrasi pembelajaran berbasis Kurikulum Merdeka dengan kurikulum sebelumnya di SD Persis. Kurikulum Merdeka adalah inovasi pendidikan yang memiliki tujuan untuk meningkatkan kualitas dan relevansi pendidikan dengan mengintegrasikan inovasi, kebebasan, dan kemampuan siswa untuk menyesuaikan diri. Penelitian ini menggunakan metode penelitian kualitatif deskriptif. Sumber data yang diambil berupa hasil wawancara, observasi, jurnal, artikel, buku, dan karya ilmiah lainnya yang relevan dan sesuai dengan objek kajian penelitian. Teknik pengumpulan data yang digunakan, yaitu observasi, wawancara dan dokumentasi. Analisis data menggunakan analisis dari Miles dan Huberman. Hasil penelitian menunjukkan bahwa integrasi pembelajaran berbasis Kurikulum Merdeka di SD PERSIS telah dijalankan dengan baik, melibatkan perencanaan yang matang, penerapan teknologi, dan penekanan pada pembentukan karakter sesuai dengan nilai-nilai Pancasila karena mencerminkan upaya untuk menciptakan generasi yang mandiri, kreatif, berkebinekaan, dan berakhlak mulia sesuai dengan nilai-nilai bangsa Indonesia. Kata Kunci: kurikulum merdeka, integras, pembelajaran
OPTIMALISASI STRATEGI “HATDISNETKOM” (LIHAT DISKUSI NULIS INTERNET KOMUNIKASI) PADA MENULIS PUISI
Authors: Indriati Dwi Astuti
Published: April 2024

Penelitian ini bertujuan untuk  mengoptimalkan Strategi “Hatdisnetkom” (Lihat Diskusi Nulis Internet Komunikasi) pada menulis puisi. Penelitian ini berjenis penelitian tindakan kelas dengan menggunakan model Kemmis dan Taggart. Desain penelitian ini, setiap siklus tindakannya meliputi perencanaan, tindakan, observasi dan refleksi yang dilaksanakan 2 siklus. Penggunaan Hatdisnetkom dapat meningkatkan menulis puisi. Siklus I nilai rata-rata 76 dan siklus II nilai rata-rata 81. Kesimpulan dari PTK ini adalah Hatdisnetkom dapat meningkatkan keterampilan menulis puisi.
Lessons in Readiness: Self-determination and student agency in careers, employability, and success
Authors:   Kate Daubney: Careers & Employability, Daubney Kate
Published: April 2024

Many university careers services sit structurally within the broad family of “Student Success”, but in practice, their strategic drivers often look quite different. While university student success strategies often claim to be focused on the student’s holistic journey into and through the university, then out into the world, careers services’ success in supporting students’ transition out is often reduced to data measuring and judged by the outcome of that journey in terms of work or further study after graduation (e.g., Gasevic et al., 2019; Knox, 2017). Consequently, careers services can find themselves unwittingly trapped within a contradiction. On one hand, they are existentially motivated to support the student’s individual journey and the diversity of their future outcomes. On the other hand, they—and the student—are judged on the nature of those outcomes. This contradiction has—in the United Kingdom (UK) at least—led to some important and innovative approaches by university careers services to enabling students’ agency through their readiness to progress on that journey. But I think those approaches also surface some important questions with relevance to all student services about what we mean when we talk about agency.
bahasa indonesia
Authors: Wandani Elliza Rizki
Published: April 2024

Biaya produksi merupakan biaya utama yang dikeluarkan oleh perusahaan manufaktur untuk memperoleh pendapatan dan keuntungan. Oleh karena itu, Usaha Puding Lamota sebagai usaha manufaktur perlu mengkaji pengaruh biaya produksi terhadap laba usaha pada beberapa periode produksi agar dapat dijadikan acuan produksi pada periode berikutnya. Jenis data yang digunakan dalam penelitian ini adalah data kuantitatif dan diperoleh dari sumber sekunder (laporan keuangan dan dokumen keuangan atau catatan dan kwitansi) unit usaha. Data tersebut terdiri dari data biaya produksi dan laba usaha Puding Lamota. Analisis data dalam penelitian ini menggunakan teknik analisis regresi linier sederhana dimana variabel bebasnya adalah biaya produksi (X) dan variabel terikatnya adalah laba usaha (Y). Hasil penelitian menunjukkan rata-rata laba usaha selama enam periode produksi sebesar Rp815.333 dan rata-rata biaya produksi sebesar Rp1.835.000. Selain itu penelitian ini menunjukkan terdapat pengaruh positif dan signifikan biaya produksi terhadap laba usaha Puding Lamota
bahasa indonesia
Authors: Maelani Mia
Published: April 2024

Usaha Puding Lamota merupakan salah satu usaha baru yang digeluti oleh mahasiswa Fakultas Ekonomi dan Manajemen Universitas Samawa Sumbawa Besar. Sebagai usaha baru maka sebelum usaha tersebut dikembangkan atau sebelum melakukan perluasan usaha maka usaha tersebut harus dilakukan terlebih dahulu. sebaiknya dilakukan analisis kelayakan usaha agar ada gambaran keberlangsungan usaha dimasa yang akan datang. Terdapat beberapa aspek kelayakan dari sudut pandang ekonomi antara lain Net Benefit Cost Ratio dan Payback Period. Hasil analisis menunjukkan bahwa B/C Ratio pada usaha Puding Lamota sebesar 1,15. Hasil tersebut menunjukkan B/C Ratio > 1 maka usaha Puding Lamota layak untuk dilanjutkan. Sedangkan Payback Period (PP) pada usaha Puding Lamota diperoleh selama 1 tahun, artinya usaha Puding Lamota mampu mengembalikan biaya investasi setelah usaha tersebut bertahan selama 1 tahun. Hal ini tentunya relatif cepat sehingga usaha tersebut layak untuk dijalankan.
Opinion: A Seven-step Approach to Communication about Animal Research
Authors: Sandgren Eric P
Published: April 2024

Organizations that receive public money to conduct research using animals should be able to explain the importance of and need for that work. More generally, anyone who believes that properly conducted and regulated animal research either does or does not make the world a better place wants the public to understand why they hold their belief. In a world with divided support for animal research, honest communication about these issues is essential to develop sound public policy. Specifically, communication about animal research (or any type of research) needs to address the scientific, ethical, and regulatory considerations that underlie public policy decisions. This opinion article describes a 7-step communication strategy designed to address these issues. The 7 elements of this approach are 1) motivation, 2) the right mix of information, 3) a team approach, 4) respect for your audience, 5) determination and courage, 6) humility and honesty, and 7) persistence.
Evaluating a Reduction in Treatment Duration of Ivermectin Diet for Fur Mite (Radfordia affinis) Eradication in Mice
Authors: Hanson Wai H , Samuels Cayden J , Woods Cheryl L , Henderson Kenneth S
Published: April 2024

Murine fur mites are commonly excluded in modern research animal programs, yet infestations continue to persist due to challenges in detection and control. Because all diagnostic methods and treatment options have limitations, programs must make many operational decisions when trying to eradicate these ectoparasites. The primary aim of this study was to assess various durations of treatment time with an ivermectin-compounded diet in eliminating Radfordia affinis in mice as determined by PCR testing and pelt examination. A shorter treatment duration would be highly advantageous as compared with the current regimen of 8 wk as it would minimize cost and time for animal management programs, impediments to research, and ivermectin drug effects on infested animals. Five experimental groups of R. affinis-positive mice received dietary ivermectin for 0, 2, 4, 6, or 8 wk. A fur mite-negative, naïve mouse was added to each group every 8 wk to perpetuate the infestation and amplify any remaining populations of fur mites. At 16 wk after the respective treatment end, PCR testing was performed for all treated groups in conjunction with the positive control group (no treatment). Visual examination of pelts for mites and eggs via direct microscopy was also performed at each time point. All treated mice were free of R. affinis at 16 wk after the end of treatment as confirmed by both PCR testing and pelt examination. These findings indicate that a dietary ivermectin treatment duration of as little as 2 wk is effective in eliminating R. affinis, making successful eradication initiatives more achievable.
Assessing the safety and effectiveness of the bivalent vaccine against respiratory syncytial virus in pregnant women: a systematic review
Authors: A Bengolea , F Chamorro , HN Catalano , A Izcovich
Published: April 2024

Objective
The aim of this systematic review is to conduct a comprehensive assessment of the efficacy and safety of the bivalent vaccine against the respiratory syncytial virus (RSV) compared to the placebo or the absence of vaccination in pregnant women to inform a clinical recommendation at the internal medicine department of Hospital Alemán of Buenos Aires.

Methods
In order to identify randomized clinical trials that evaluate our question of interest, we carry out thorough searches in Epistemonikos and Pubmed, from the date of creation of each source until January of the year 2024. Additionally, we consider additional sources to identify referencias that could not have been identified through electronic search. Two reviewers independently selected the studies included, extracted data and evaluated the risk of bias. We perform a quantitative synthesis (meta-analysis) and prepare summary tables of findings as recommended by the Grade Group.
The results of this review were presented to a team of clinical experts of the internal medicine department of Hospital Alemán of Buenos Aires who analyzed and issued judgments for each of the criteria proposed within the framework of evidence to the decision. After issuing the judgments for each criterion, experts formulated the clinical recommendation for the problem of interest.
Result
Through the search strategy, 331 references were identified that were examined by title and summary. Of these, 14 references for the evaluation by full text were included. Finally, 2 randomized clinical trials were included.
The bivalent vaccine against RSV in pregnant women probably decreases the risk of respiratory infection, severe respiratory infection and hospitalization by RSV in the newborn.
The bivalent vaccine against RSV in pregnant women probably does not increase the risk of presenting serious adverse events in the mother and does not generate an increase in non -serious adverse events (both in the mother and in the newborn).
The bivalent vaccine against RSV in pregnant women could generate a slight increase in serious adverse events in the newborn (13 more events for 1,000 newborns), however the certainty of evidence is low.
Clinical recommendation
Based on this body of evidence, the German Hospital of Buenos Aires conditionally recommends the use of the bivalent vaccine for RSV in pregnant patients (32 to 36 weeks of gestation) (CONDITIONAL RECOMMENDATION IN FAVOR, LOW CERTAINTY IN THE EVIDENCE).
Conclusions
The bivalent vaccine against RSV in pregnant women presents significant benefits by reducing the risk of severe respiratory infections in newborns, supported by overall safety in pregnant women.
Investigation of the Relationship Between Mothers' Perceptions of Risky Play and Their Children's Self-Concepts
Authors: Çelik Fatma Nur , Karaca Nezahat Hamiden , Kaya Ümit Ünsal
Published: April 2024

This study was conducted to determine the relationship between the perceptions of mothers of children attending preschool institutions about risky play and children's self-concept and the relationship between gender. In line with this purpose, it was conducted using the relational survey model, one of the quantitative research methods. The sample of the study was determined using the convenience sampling method. The sample of the study consisted of 257 volunteer children and the mothers of the same children. In the study, a general information form developed by the researcher was used to obtain information about the demographic characteristics of the children and their families. As a data collection tool, "Scale for the Attitudes Towards Risky Play at Early Childhood - Parent Form (SATRPEC-PF)" was used to evaluate mothers' perceptions about risky play, and Perception of Child Self-Concept (PCSC) was used to evaluate children's self-concept. The data obtained from the study were created using Spearman Rank Correlation analysis. When the scores obtained from SATRPEC-PF and PCSC were compared, a positive correlation was found between PCSC scores and Pro-beliefs scores from SATRPEC-PF sub-factors, and a negative correlation was found between Feeling Anxiety. No significant relationship was found between Distinguishing Risky Behaviors, Supporting Children, and Parental Support factors. While there was a significant relationship between girls' PCSC scores and SATRPEC-PF Pro-beliefs sub-factor, Distinguishing Risky Behaviors sub-factor, and Feeling Anxiety sub-factor, no significant relationship was found between the Supporting Children and Parental Support sub-factors. A significant relationship was found only between boys' PCSC scores and the Pro-beliefs sub-factor of SATRPEC-PF. Suggestions were presented in line with the findings obtained from the study.
Determination of Some Physicochemical Properties of Binary Biodiesel and Binary Biodiesel-Diesel Blend Fuels Obtained from Waste Pumpkin Seed- Camelina Oils
Authors: Şahin Seda
Published: April 2024

The primary aim of utilizing biodiesel is to reduce dependency on fossil fuels, decrease harmful emissions, and promote the use of renewable energy sources. Studies on biodiesel commonly revolve around singular biodiesel-petroleum diesel blends. Binary biodiesel is generally obtained by mixing different types of biodiesel or blending these mixtures with petroleum diesel. The combination of these diverse feedstocks with distinct properties can offer varying characteristics and benefits. Many studies regarding liquid biofuels primarily focus on blends of singular biodiesel with diesel. Raw materials constitute a substantial portion of the cost in biodiesel production. Hence, efforts have been made to favor non-edible and waste products as raw materials. Additionally, products that are suitable for cultivation in Turkey and easy to obtain as raw materials, supporting domestic biofuel production, have been chosen. Biodiesels obtained from waste pumpkin seeds and linseed oils through the transesterification method were blended at volumetric ratios of 1:1 and 1:3 to obtain binary biodiesel fuels (C50P50, C25P75, and C75P25). The binary biodiesel-diesel blend fuels were achieved by blending different volume ratios of binary biodiesel fuels (C25P25D50 and C10P10D80) with traditional petroleum diesel after their preparation. Subsequent analyses focused on determining the physicochemical properties (density, kinematic viscosity, flash point, water content, calorific value, cold filter plugging point, and copper strip corrosion) of the prepared binary biodiesel and binary biodiesel-diesel blend fuels. Compliance with biodiesel standards (EN 14214, ASTM D-6751) was observed for all fuels, and the results were compared with the reference fuel, diesel (petroleum). According to the analysis results, all the tested fuels met the standards, with the C10P10D80 blend fuel displaying the closest resemblance to diesel.
Investigation of Olive Production in Ten-Year Period in 1961-2021 Years
Authors: Uzundumlu Ahmet Semih , Ateş Tuba
Published: April 2024

Despite its many nutritional characteristics, the number of countries producing olives is limited owing to the growing conditions. Because the olive is a drought-resistant plant, it is one of the fruits that are least affected by climate change. For this reason, in this study, the production areas and the changes in production among global leading olive producing countries were determined for 1961-2021 years. In addition, the Concentration Ratio (CR) and Herfindahl-Hirschman (HH) indices were used to determine the competitive situation in olive production in this study, while the Revealed Comparative Advantage (RXA) index was used in the competition in fruit production areas. According to research, while 32-33 countries produced olives in 1961-1980, the five leading countries were Italy, Spain, Greece, Turkey, and Portugal/Tunisia. In this period, the HH index was over 1.800, and the share of the five countries was approximately 83.55%. During the 1981-2010 periods 32-38 countries produced olives: Spain, Italy, Greece, Turkey, and Tunisia were the leading countries, while Spain was the premier country. According to the HHI, the market is a monopolistic competition, but according to the concentration ratios, it shows the characteristics of an oligopolistic market. Countries with competitive positions in olive production are listed from strong to weak, such as Tunisia, Greece, Morocco, Spain, Portugal, Italy, and Turkey. While the number of countries producing olives has increased slightly in recent years, conspicuous matters worldwide have been climate change and technological developments in the last years. Considering these situations, countries that reduce costs in olive production and develop technologies that increase yield and quality from unit areas will be one step ahead of the competition. In addition, since this market is generally an oligopoly market, each prolific country will not be disadvantaged by closely following the activities of other countries.
THE INFLUENCE OF EXPERIENTIAL MARKETING ON SELF SERVICE CUSTOMER SATISFACTION
Authors: Adabiyah Siti Layyinatul , Rachmawati Fitria Dwi , Fawaid Nurul , Qomariah Nurul
Published: April 2024

This research aims to determine the impact of experiential marketing on customer satisfaction at the Madinah Mart Cangkring Jember Store. The population in this study were all buyers at the Madinah Mart Cangkring Jember Store. The planned sample size in this research was determined to be 50 respondents. The independent variables from this research are sense, feel, think, act and relate. Meanwhile, the dependent variable is customer satisfaction. The data analysis that will be used in this research is descriptive analysis, analysis of validity and reliability tests, analysis of research hypothesis testing. The research is expected to produce that the variables sense (X1), feel (X2), think (X3), act (X4) and relate (X5) can provide a significant increase in customer satisfaction at the Madinah Mart Cangkring Jember Store
Enhancing Capacity Building Prior to Appointment as Heads of Departments in Universities
Authors: Dogbatse Diana Ama
Published: April 2024

Developing the capacity of prospective heads of departments (HoDs) at universities is essential for promoting effective leadership and enhancing performance within higher academic institutions. This research investigated capacity building prior to appointment as a HoD in Ghana. The study aimed to enhance capacity building of heads of departments prior to their appointment as heads at the University of Cape Coast. A descriptive survey design was used, and 40 Heads of Department across the University Campuses were sampled for the study. A structured questionnaire was used for the data collection. Data was analyzed using descriptive statistics. Findings show that all the academic HoDs in this study have not been offered any orientation/workshop or formalized training before their appointments as Heads of Departments. Most of the HoDs desired to acquire office procedures skills before they were appointed HoDs. This study has shown that academic HoDs in the University of Cape Coast do not have any orientation/workshop or formalized training prior to appointments as heads of departments. The university should provide training programmes and workshops for academic candidates (Senior Lecturers/Associate Professors/Professors) who are eligible for appointment as heads of departments to improve their administrative skills and competencies before their appointments to the position of HoDs.
The Influence of Physical Training on The Flight Performance of Cadets
Authors: Islam Fajar , Aristo Muhammad Rosihan
Published: April 2024

This research was conducted to investigate the effect of physical exercise on the flight performance of fixed-wing cadets at Indonesia Civil Pilot Academy in Banyuwangi. The research employed a quantitative methodology, utilizing data collection through a questionnaire. The questionnaire was distributed to the cadets selected as samples, specifically DIII PST 2, DIII PST 3, and DIII PST 4 cadets, with 43 participants. Based on the instrument test conducted using regression analysis with ANOVA, it was found that the regression model (H1) significantly explained the variation in the observed data, with a significant F-ratio of 33.153 and a very low p-value (<.001). The hypothesis test results revealed that the coefficient for the dependent variable, flight performance, was 0.728, with a standard error of 0.126. The standardized coefficient (standardized) for this variable was 0.669. The obtained t-value was 5.758. The research findings indicate a significant influence of the independent variable, "physical exercise", on the dependent variable, flight performance. Aviation training facilities can use the results of this study to develop policies that encourage the inclusion of hands-on training in the flight curriculum. By doing this, you can ensure cadets are in good enough physical shape to complete their flight training. This study's results may open the door for the creation of fresh hypotheses on the connection between physical preparation and flying performance. The results of this study may serve as the foundation for creating a novel conceptual framework in this area.
Türkiye’de Kırsal Alanların Marjinalleştirilmesi
Authors: Taşkan Gaye , Görmüş Cengiz Sevgi
Published: April 2024

Türkiye’de küreselleşme hareketleri ve neoliberal politikaların etkisi ile kentlerin politik, ekonomik ve kültürel anlamda merkezileşmesi, kentsel ve kırsal alan arasında güç dengesizliğini ve eşitsizliği beslemektedir. Dolayısıyla Türkiye’de kırsal alan çalışmalılarında daha çok eşitsizliklerin giderilmesi ya da hafifletilmesine yönelik çaba harcanmaktadır. Bu çalışmanın odağında eşitsizliklere çözüm üretmek değil, kent karşısında kırsalın eşitsiz konuma indirilmesinin yani marjinal olarak algılanmasının altında yatan nedenleri anlama çabası yatmaktadır. Kırsal alanın algılanma biçiminin, alanın planlanmasında etkili olduğu yargısı ile yapılan bu çalışmada, kent ve kır arasında merkez-çevre teorisi kapsamında üretilen kırsal alana yönelik dışsal marjinallik algısı Malatya İli örneğinde planlama uzmanlarının görüşlerine dayanarak değerlendirilmektedir. İlin planlamasından sorumlu uzmanlarla yapılan yarı yapılandırılmış görüşmelerden elde edilen temalar kırsal ve kentsel alanın birlikte planlanamamasının zorluklarını ortaya koyarken, planlamada düzeyler ve ölçekler arası bilgi akışının uzmanların marjinallik algısını beslediği tespit edilmiştir. Özellikle politik boyutta hâkim olan kentsel değerlerin aşkınlaştırılmasına yönelik söylemler dışsal marjinallik kapsamının genişlemesine ve kırsal alanda eşitsizliğin artmasına neden olmaktadır. Eşitsizliğin artması ile birlikte kırsal alanın kendine özgü üretim biçimleri ile karakterize olmayan bir biçimde yeniden üretim sürecine dâhil olarak, alana yönelik tanımsızlık aşılamaz bir aşamaya varmaktadır. Kırsal alana yönelik marjinallik tiplerinin ve faktörlerinin belirlenmesi kent-kır etkileşiminin bütünsel planlaması ve planlamada önceliklerin tespitinde önemli bir araç olarak kullanılmalıdır.
Renormalized vacuum field interaction as an explanation for dark energy and its implications
Authors: Martinez Dino
Published: April 2024

In this paper, we attribute the phenomena of dark energy to the interaction of the renormalized vacuum field with charged particles. We test our theory by deriving the dark energy density due to this interaction while staying within the classical domain. Up to a redshift of z = 2, we obtain a value of 5.37x10-10 J/m3, agreeing with observation. We then briefly discuss the implications concerning Hubble tension and the possible support of a proposed dark matter candidate due to the methods we’ve implemented.