bluuebunny/crossref_metadata_2025 huggingface dataset:
High-k Dual Crosslinkable Polymer Nanocomposite Dielectrics Based on P(MMA-co-HEMA)/BaTiO 3 for Film Capacitors
Authors: Hou Xiaoya , Zhang Yulei , Yin Zhangmin , Zhang Jie
Published: August 2023

In order to obtain high-quality photocrosslinkable polymer matrix, cinnamoyl chloride functionalized poly(methyl methacrylate-co-2-hydroxyethyl methacrylate) [f-P(MMA-co-HEMA)] was synthesized. The functionalization and photocrosslinking of the polymer were confirmed through FTIR, 1H NMR, and UV characterization. In order to obtain high-quality, flat and pinhole-free polymer films, the effects of different photocrosslinked processes on the polymer film quality were investigated. When the crosslinking time was 10 min and the crosslinking degree was 55%, the dielectric constant of the capacitor reached to 4.65, the dielectric loss was as low as 0.04, the dielectric strength was as high as 343 V/µm, and the maximum energy density was 2.4 J/cm3. In order to obtain composite materials with high dielectric constant, photocrosslinkable functionalized copolymer f-P(MMA-co-HEMA) was used as the polymer matrix, and surface modified BT with phosphoric acid was introduced through ball milling dispersion to prepare photocrosslinkable f-P(MMA-co-HEMA)/m-BT composite film. By surface and cross-sectional SEM characterization, BT was uniformly dispersed in the polymer matrix. FTIR confirmed that the C = C group on the surface modified BT disappeared after photocrosslinking, which formed chemical binding between the two phases in the nanocomposite material, and the composite material formed a double crosslinking network structure. When the BT content was 30 wt%, the dielectric constant reached up to 51. With the bending angle of the capacitor changed by 120֯, the capacitance value changed by 27%, indicative of good sensitivity.
Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence
Authors: Oudin Anais , Moreno-Sanchez Pilar M. , Baus Virginie , Niclou Simone P. , Golebiewska Anna
Published: August 2023

Background
Preclinical in vivo cancer models are essential tools for investigating tumor progression and response to treatment prior to clinical trials. Although treatment modalities are regularly assessed in mice upon tumor growth in vivo, surgical resection remains challenging, particularly in the orthotopic site. Here, we report a successful surgical resection of glioblastoma (GBM) in patient-derived orthotopic xenografts (PDOXs).
Methods
We derived a cohort of 46 GBM PDOX models accurately recapitulating human disease in mice. To assess feasibility of surgical resection in PDOXs, we selected two models representing histopathological features of GBM tumors, including diffuse growth into the mouse brain. Tumor growth was detected with magnetic resonance imaging (MRI). Surgical resection in the mouse brains was performed based on MRI-guided coordinates. Survival study followed by immunohistochemistry-based evaluation of recurrent tumors allowed for assessment of clinically relevant parameters.
Results
We show that a surgical resection protocol in mice carrying diffuse GBM tumors in the brain leads to clinically relevant outcomes. We demonstrate the utility of MRI for the noninvasive assessment of in vivo tumor growth, preoperative programming of resection coordinates and follow-up of tumor recurrence. Similar to neurosurgery in patients, we achieved a near total to complete extent of tumor resection, and mice with resected tumors presented significantly increased survival. The remaining unresected GBM cells that invaded the normal mouse brain prior to surgery regrew tumors with similar histopathological features and tumor microenvironments to the primary tumors.
Conclusions
Our data positions GBM PDOXs developed in mouse brains as a valuable preclinical model for conducting therapeutic studies that involve surgical tumor resection. Additionally, these models hold promise for the development of enhanced image-guided surgery protocols.
Role and Clinical Significance of Thromboelastography-Guided Individualized Antiplatelet Therapy in Non-cardiogenic Ischemic Stroke: A Retrospective Cohort Study
Authors: Zhang Yifan , Wang Moli
Published: August 2023

This study examined the impact of individualized antiplatelet (IA) therapy guided by Thromboelastography (TEG) in non-cardiogenic ischemic stroke patients. The patients were divided into an IA group and a control group receiving conventional treatment. A one-year follow-up tracked mortality, bleeding events, and ischemic events. 715 patients were initially enrolled, with 684 meeting the inclusion criteria (487 in IA group, 197 in control group). IA therapy significantly reduced the composite rate of death, bleeding, or ischemic events compared to conventional therapy (7.39% vs. 15.74%, P = 0.001). The IA group showed a lower incidence of combined bleeding or ischemic events (6.98% vs. 15.32%, P = 0.001). Furthermore, the IA group had lower rates of ischemic stroke (2.46% vs. 5.58%, P = 0.04) and myocardial infarction (3.08% vs. 6.6%, P = 0.035) compared to the control group. Cox regression analysis revealed that age (hazard ratio, 1.043; 95% CI, 1.01-1.078, P = 0.011) and coronary artery disease (hazard ratio, 1.902; 95% CI, 1.147-3.153, P = 0.013) were associated with increased risk of adverse events compared to the control group. A therapy guided by platelet function testing can effectively reduce adverse events, particularly the risk of ischemic events, in the clinical prognosis of ischemic stroke. However, Caution is needed in IA therapy for elderly and coronary heart disease patients due to potential risks. Further large-scale experiments are required to validate and optimize personalized antiplatelet therapy in this population.
Trial Registration clinicaltrials.gov Identifier: NCT 03471169
Association between Economic Status and Post-stroke Depression in Middle and Older Age: Results from China Health and Retirement Longitudinal Study (CHARLS)
Authors: Cai Qianru , Qian Mengyi , Chen Meiling
Published: August 2023

Introduction: Post-stroke depression (PSD) is a common neuropsychiatric complication that affects approximately one-third of stroke patients. The prognosis and treatment of this disease are poor.There have been many studies exploring PSD risk factors, but previous studies have rarely focused on economic conditions and have not explored the role of urban-rural differences in PSD. Given the substantial population of stroke patients in China, it is crucial to examine the potential risk factors, including economic factors, contributing to PSD. By conducting studies on this population and investigating the influence of economic conditions, we can gain valuable theoretical insights to guide PSD prevention and management.
Methods: We utilized data from the 2018 CHARLS and selected appropriate samples for analysis. Depressive symptoms were assessed using the CES-D 10 scale, a validated tool for measuring depressive symptoms in the general population. Multiple logistic regression analysis was employed to assess the association between economic status and post-stroke depression and evaluate any urban-rural differences.
Results: Of the 1009 respondents in the study, 446 (44.2%) had depression. After adjusting for all covariates, we found that in the urban sample, participants with more health insurance cases had a lower risk of PSD (OR=0.19, 95% CI: 0.04-0.85, P=0.03). Conversely, in the rural sample, a significant correlation was reported between individual annual income and PSD occurrence (OR=0.19, 95% CI: 0.05-0.73, P=0.02).
Conclusions: Self-reported health status, number of other disabilities, night sleep duration, ADL, and life satisfaction also influenced PSD. The research results confirm that the increase of incidence rate of post-stroke depression (PSD) is related to many factors. Higher prevalence rates were observed in individuals with poorer economic conditions. This connection is particularly evident when comparing urban and rural areas. By addressing these factors and improving the economic situation, we can reduce the prevalence of PSD and strengthen comprehensive management of this situation.
The antihyperglycemic potential of pyraozolobenzothiazine 1,1-dioxide novel derivative in mice using integrated molecular pharmacological approach
Authors: Taj Saman , Ashfaq Usman Ali , Ahmad Matloob , Noor Hasnat , Ikram Ayesha , Ahmed Rashid , Tariq Muhammad , Masoud Muhammad Shareef , Hasan Anwarul
Published: August 2023

Diabetes Mellitus (DM) is a extensively studied metabolic disease characterized by elevated blood sugar levels caused by inadequate insulin production, which subsequently leads to hyperglycemia. This study was intended to investigate the in silico, in vitro, and in vivo antidiabetic potential of pyrazolobenzothiazine derivatives. Molecular docking of pyrazolobenzothiazine derivatives was performed against α-glucosidase and α-amylase and compounds were selected based on docking score, bonding interactions and low root mean square deviation (RMSD). In vitro enzyme inhibition assay against α-glucosidase and α-amylase was performed using p-nitrophenyl- α -D-glucopyranoside (PNPG) and starch substrate. Synthetic compound S1 exhibits little conformational changes during MD simulation run at 100ns. S1 also revealed effective IC50 values for α-glucosidase (3.91 µM) and α-amylase (8.89 µM) and an enzyme kinetic study showed low ki (-0.186, -1.267) and ki’ (-0.691, -1.78) values with the competitive type of inhibition for both enzymes α-glucosidase and α-amylase, respectively. Moreover, studies were conducted to check the effect of the synthetic compound in a mouse model. A low necrosis rate was observed in the liver, kidney, and pancreas through histology analysis performed on mice. Compound S1 also exhibited good biochemical profile with lower sugar level (110–115 mg/dL), increased insulin level (25–30 µM/L), and low level of cholesterol (85mg/dL) and creatinine (0.6 mg/dL) in blood. The treated mice group also exhibited a low % of glycated hemoglobin (3%). This study concludes that S1 is a new antidiabetic agent that helps lower blood glucose levels and minimizes the complications associated with type II diabetes.
Understanding the Role of Digital Immersive Technology in Educating the Students of English Language: Does it Promote Critical Thinking and Self-directed Learning for Achieving Sustainability in Education with the Help of Teamwork?
Authors: Tang Fenghua
Published: August 2023

Purpose:Universities are constantly searching for best practices to promote sustainability when it comes to educating students of the English language. Although this area of study has recently gained the attention of scholars around the worldthere is still a need to explore it from various perspectives.
Objective:The study aims to find out how well digital immersion technology encourages teamwork, self-directed learning, and critical thinking in English language learners. The purpose of the study is to examine how students' language skills, motivation, and involvement in the learning process are affected by digital immersive technology.
Methodology:The objective was achieved by using a survey questionnaire to collect data from 304 registered students in various universities inBeijing. Data analysis was conducted by applying Mplus 7.0 software.
Findings:The findings revealed that the use of digital immersive technology was pivotal for achieving sustainable education both directly and indirectly to an extent. In addition, team working moderated all the respective paths except the path involving the use of digital immersive technology and critical thinking.
Implications:These results generated implications for teachers and policymakersto promote and facilitate the use of digital technology for teaching the English language to students, encouraging them to develop critical skills and self-directed learning strategies. The study also offered guidance and deeper understanding for researchers to address the concerns linked to the use of digital technology and sustainable education particularly in their future endeavors.
Assessment of Frailty in patients with Advanced Chronic Kidney Disease and the role of Circulating Microvesicles
Authors: Gimena Rocio , Valera Gemma , Rodriguez Maria del Mar , Perez Maria , Arevalo Juan , Waikar Sushrut , Ramirez Rafael , Rodriguez Diego , Carracedo Julia , Martinez Patricia
Published: August 2023

Frailty is a highly prevalent syndrome inpatients with advanced age and chronic diseases, and it is associated with atherothrombotic pathologies, suggesting a procoagulant state in these patients. Circulating microvesicles (cMVs), are small phospholipid-rich vesicles, which have been shown to participate in atherothrombotic onset and progression. We aim to analyze frailty in patients with advanced chronic kidney disease (CKD), and to determine the role of microvesicles in this population.
We conducted a prospective cohort study with 85 patients with advanced CKD. Fried's five criteria were used to define frailty. We obtained blood for cMVs analysis by flow cytometry. There was a follow-up time of 27 months during which dialysis initiation and mortality was assessed.
The prevalence of frailty in patients with advanced CKD was 27%. We found that risk factors for frailty were age, type 2 diabetes mellitus and anemia. Total cMVs, platelet derived cMVs and endothelial derived cMVs were significantly higher in frail patients. CD142 (platelet tissue factor), a procoagulant marker, was also significantly higher in frail patients. Although we still do not know in depth the mechanisms involved in frailty, to our knowledge this is the first study that links cMVs and frailty in patients with advanced CKD, suggesting this could be a good biomarker or therapeutic target in advanced CKD.
Comparative therapeutic efficacy of intramammary Ceftiofur hydrochloride and Cefalonium during dry period in buffaloes
Authors: Kaushik Apurv , Walwadkar Kanchan , Yadav Sarita , Boora Ashok , Vandre Rajesh Kumar , Gupta Nitin Mohan , Sharma Sapna
Published: August 2023

Subclinical Mastitis (SCM) is mainly the major form of mastitis in modern livestock dairy animals. Antibiotic dry animal therapy proves to decrease risk of early lactation SCM. This study was designed to differentiate and compare efficacy of intramammary preparations i.e., Ceftiofur hydrochloride and Cefalonium during the dry period in buffaloes. The proposed work was carried out at ICAR- CIRB, Hisar, Haryana. Seventy-five buffaloes positive for SCM were randomized in three groups with 25 buffaloes in each group- two treatment groups (T2 and T3) and one untreated control group (T1). T2 group buffaloes were treated with drug Ceftiofur hydrochloride (500 mg) and T3 group with Cefalonium formulation (250 mg). Therapeutic efficacies of both the drugs were evaluated based on bacterial cure rates and Odd Ratios (OR). T2 treatment group showed better therapeutic response as compared to T3 groups the bacterial cure rate was 88% and 48% respectively, and the Odd Ratio (OR) of treatment group T2 was 0.0057 which was lower as compared to group T3 which was 0.0451.
Research and Application of Plastic Extruder Temperature System Based on Variable Universe Fuzzy PID Control
Authors: Meng Jin-Tao , Gao Hai-Tao , Ruan Mi-Xue , Sun Wen , Guo Hai
Published: August 2023

Plastic profiles, as the basic material for social and economic development, are mainly processed and moulded by plastic extruders. In the production process of plastic profiles, the temperature precision control of plastic extruder directly affects the plasticising and mixing effect of raw mate-rials. Therefore, the development of high-precision, fast response and stable plastic extruder tem-perature control system plays a key role in the development of plastic profile industry. In order to solve the shortcomings of the plastic extruder such as low temperature precision, slow response speed and poor anti-interference ability, the author has established a plastic extruder temperature control system model based on the study of PID control strategies and fuzzy PID control strategies, combined with the structural and functional characteristics of plastic extruder. Adopting a variable universe fuzzy PID control strategy to improve the performance of the plastic extruder temperature control system. The core idea of this strategy is to introduce proportional factors to change the range of the fuzzy domain. Under the condition that the fuzzy rules remain unchanged, the fuzzy domain compresses as the error decreases and expands as the error increases. Changing the domain is equivalent to adding fuzzy control rules within the same domain, thereby completing the dynamic adjustment of PID controller parameters. Through MATLAB simulation analysis and comparison, it was found that this control strategy has the advantages of short rise time, no overshoot, and strong anti-interference compared to PID control and fuzzy PID control strategies. Finally, through ex-perimental verification, it was found that this control strategy significantly changes the temperature control effect of nonlinear time-varying extruders, and has good adaptability and stability.
Incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery: A multi- center prospective observational study
Authors: Demilie Atalay Eshetie , Denu Zewditu Abdissa , Bizuneh Yosef Belay , Gebremedhn Endale Gebreegziabher
Published: August 2023

Objective To determine incidence and factors associated with failed spinal anaesthesia among patients undergoing surgery in Amhara National Regional State comprehensive specialized hospitals, Northwest Ethiopia, 2023. Methods Multi-center prospective observational study was conducted. Data was collected using questionnaire and checklist. Data was transformed from Epi data to SPSS and logistic regression analysis was done. Both crude and adjusted odds ratio were used to assess the strength of association. Variables with a p-value of less than 0.05 were considered as statistically significant. Results A total of 532 patients were included in this study with a response rate of 98%. Incidence of failed spinal anaesthesia was 22.4% (CI = 19-25.9). Emergency surgery (AOR = 7.01, CI = 4.5–12.7), dose of bupivacaine of ≤ 10 mg (AOR = 3.02, CI = 1.3–10.2), work experience of anaesthetist < 2 years (AOR = 3.1, CI = 1.7–5.72), bloody CSF (AOR = 8.5, CI = 2.53–18.5), hyperbaric local anaesthetic drug (AOR = 3.3, 95% CI = 3.2–8.2) and local anaesthetist without adjuvants (AOR = 5.25, CI = 2.62–14.2) were associated failed spinal anaesthesia. Conclusion and recommendation: The incidence of failed spinal anaesthesia was high in Amhara Region comprehensive specialized hospitals. We suggest that anaesthesia providers should minimize failure by using adjuvants and appropriate dose of local anaesthetic. Additionally, simulation training should be given for anaesthesia trainees.
Treatment strategies for urinary tract infections based on fever
Authors: Yanagihara Takeshi , Kobayashi Koichi , Yanai Emi , Takeshita Hikaru , Tanabe Yujiro , Itoh Yasuhiko
Published: August 2023

Purpose
The duration of antimicrobial therapy for febrile urinary tract infections (fUTI) in children have not been established. This study aimed to explore the appropriate duration of the treatment for fUTI in children.
Methods
We created a protocol to determine the duration of antibiotic administration based on the fever. Transvenous antibiotics were administered for 3 days after the resolution of fever, followed by oral antibiotics for 1 week. Diagnosis of fUTI was based on a fever of 37.5°C or higher and a quantitative culture of catheterized urine showed ≥5 × 104 bacteria. Acute focal bacterial nephritis (AFBN) and pyelonephritis (PN) were diagnosed based on contrast-enhanced computed tomography (eCT) findings. We retrospectively reviewed the treatment outcomes.
Results
Of the 78 patients treated according to our protocol, 58 were included; 49 with PN (30 men) and nine with AFBN (three men). Blood test results showed that patients with AFBN had significantly higher white blood cell and C-reactive protein levels than those with PN; however, no differences were observed in the urinary findings and causative bacteria. The time to resolution of fever and duration of intravenous antibiotic administration were significantly longer in patients with AFBN than in those with PN. However, the average duration of AFBN treatment was 14.2 days, which was shorter than the previously reported 3-week administration and no recurrence was observed in AFBN patients.
Conclusions
The protocol created to determine the duration of antimicrobial treatment based on fever is useful. Invasive examinations, such as eCT, are not required.
Addressing Challenges in Diagnostic X-ray Dosimetry: Uncertainties and Corrections for Al2O3:C-based Optically Stimulated Luminescent Dosimeters
Authors: Wong Jeannie Hsiu Ding , Ismail Wan Hazlinda
Published: August 2023

The use of Al2O3:C-based optically stimulated luminescent dosimeters (OSLDs) in diagnostic X-ray is a challenge because of their energy dependence (ED) and variability of element sensitivity factors (ESFs). This study aims to develop a method to determine ED and ESFs of Landauer nanoDot™ OSLDs for clinical X-ray and investigate the uncertainties associated with ESFs. An area of 2 x 2 cm2 at the central axis of the X-ray field was used to establish the ESFs. A total of 80 OSLDs were categorized into “controlled” (n = 40) and “less-controlled” groups (n = 40). The ESFs of the OSLDs were determined using an 80 kVp X-ray in free-air geometry. The OSLDs were cross-calibrated with an ion chamber to establish the average calibration coefficient and ESFs. The OSLDs were then irradiated at tube potentials ranging from 50 to 150 kVp to determine their ED. The uniformity of the X-ray field was ± 1.5% at 100 cm source-to-surface distance. The batch homogeneities of user-defined ESFs were 2.4% and 8.7% for controlled and less-controlled OSLDs, respectively. The ED of OSLDs ranged from 1.125 to 0.812 as tube potential increased from 50 kVp to 150 kVp. The total uncertainty of OSLDs, without ED correction, could be as high as 16%. After applying ESF and ED correction, the total uncertainties were reduced to 6.3% in controlled OLSDs and 11.6% in less-controlled ones. OSLDs corrected with user-defined ESF and ED can reduce the uncertainty of dose measurements in diagnostic X-ray, particularly in managing less-controlled OSLDs.
Concurrent analysis of genome and transcriptome in one single cell
Authors: Heid Johanna , Cutler Ronald , Lee Moonsook , Vijg Jan , Maslov Alexander Y.
Published: August 2023

Thus far, multiple techniques for single cell analysis have been developed, yet we lack a relatively simple tool to assess DNA and RNA from the same cell at whole-transcriptome and whole-genome depths. Here we present an updated method for physical separation of cytoplasmic RNA from the nuclei, which allows for simultaneous studies of DNA and RNA from the same single cell. The method consists of three steps – 1) immobilization of a single cell on solid substrate, 2) hypotonic lysis of immobilized single cell, and 3) separation of cytosol containing aqueous phase and immobilized nucleus. We found that DNA and RNA extracted from single cell using our approach is suitable for downstream sequencing-based applications. We demonstrated that the coverage of transcriptome and genome sequencing data obtained after DNA/RNA separation is similar to that observed without separation. We also showed that the separation procedure does not create any noticeable bias in observed mutational load or mutation spectra. Thus, our method can serve as a tool for simultaneous complex analysis of the genome and transcriptome, providing necessary information on the relationship between somatic mutations and the regulation of gene expression.
Expedited Triage for Outpatients Referred to Cardiology for Chest Pain: A Model to Improve Access
Authors: Klaybor Monica , Keck Carson , Lateef Azalfa , Weaver Taelor , Northup Amanda
Published: August 2023

Cardiovascular disease remains the leading cause of death in the US, especially in the veteran population. Prompt evaluation is crucial for clinical outcomes, but demand for services often exceeds the healthcare system’s capacity. The extended outpatient wait time for patients with chest pain prompted the development and implementation of a Chest Pain Consult at Ralph H Johnson VA Medical Center. A cardiology fellow reviews the consult and performs a phone interview with the patient within 48 hours of the referral. The fellow either refers the patient for further testing or discharges back to primary care. This retrospective cohort study compared access before and after the implementation of the expedited Chest Pain Consult. We analyzed 107 patients (52 pre- and 55 post-implementation). When comparing the pre- and post-implementation groups, we detected a statistically significant reduction in time intervals between referral to initial physician contact, non-invasive testing, and resolution. A decrease in the interval between referral and left heart catheterization was not statistically significant. Chest Pain Consults led to faster ischemic evaluation for veterans. The expedited Chest Pain Consult can be a model for other healthcare institutions to accelerate access for patients with symptoms of cardiovascular disease.
Peer-led safer supply and opioid agonist treatment medication distribution: a case study from rural British Columbia
Authors: Scow Marnie , McDougall Jenny , Slaunwhite Amanda , Palis Heather
Published: August 2023

Background: British Columbia (BC) has been facing a public health emergency of overdose since 2016, with rural regions of the province facing the highest rates of death. Peers (in this case, people with lived experience of substance use) are known to be effective patient navigators in health system and can play a role in connecting patients to care and reducing overdose risk.
Case Presentation: We outline a peer-led program focused on opioid agonist treatment and safe supply medication delivery at a clinic in rural BC that began in March 2020. The peer takes an Indigenous harm reduction approach and is focused on meeting the needs of the whole person. The peer has regular contact with approximately 50 clients and navigates medication delivery and appointments for approximately 10-15 people each day. Clients have been retained on the medication, and experienced improvement in other outcomes, including securing housing, employment and managing other health issues. The peer has established contact with clients since March 2020 to support engagement with health care and continuity of medication access. This program highlights the importance and value of peer-led work and need for further investments in peer-led programs to respond to the overdose crisis
Conclusions: This peer-led intervention is a promising approach to engaging people who remain disconnected from health services in care in a rural community. This model could be adapted to other settings to support patient contact with the health system and medication access and continuity, with the ultimate goal of reducing overdose risk.
Compost and vermicompost enhances the growth, uptake and quality of zucchini plants (cucurbita pepo l.) grown on sandy soils
Authors: Rekaby Saudi A. , Ghoneim Adel M. , Gebreel Mostafa , Ali Waleed , Yousef Ahmed F.
Published: August 2023

Producing of safe food from alkaline sandy soils under high rates of chemical fertilization is a serious concern in Egypt. Compost and vermicompost can improve soil fertility and crop production, but their application has not been well evaluated in zucchini (Cucurbita pepoL.) cultivation. This study aimed to determine the effects of compost and vermicompost on the yield, nutrient uptake of zucchini as well as on soil properties under field conditions. Four fertilization treatments, including a control without fertilization (CO), chemical fertilizer (CF), compost (CT), and vermicompost (VC) were arranged in a randomized complete block design with five replications. The results showed that CT and VC application significantly increased the yield of zucchini by 17 and 53%, respectively, in comparison with CF treatment. In addition, CT and VC treatments significantly increased the soil organic matter, soil availability of NPK compared with those in the CO and CF treatments. The application of the CT and VC amendments increased the N, P and K uptake significantly as compared to the CO and CF treatments. The highest values of N, P and K use efficiency were found in the CT treatment. The highly significant and positive correlation was found among different soil properties and zucchini traits. CT and VC are crucial for increasing productivity, improving fruit quality, and yield of zucchini fruit and can be used as an alternative to chemical fertilizers for zucchini cultivation.
Status and perspectives for rice irrigation in the Mediterranean Basin
Authors: Arbat Gerard , Gharsallah Olfa , Cufí Sílvia , de Cartagena Francesc Ramírez , Pinsach Jaume , Romani Marco , Mira Concepción , Lima Isabel P. , Gerardo Romeu , Gonçalves José M. , Nunes Manuel , Aboukheira Abdrabbo A. A. S. , Shebl Saad M. Metwaly , Enginsu Melih , Ünan Rasim , Rienzner Michele , Facchi Arianna
Published: August 2023

In the Mediterranean basin, rice is cultivated in approximately 1,000,000 hectares. The most important rice-producing countries in the region are Egypt, Italy, Türkiye and Spain. In all these areas, rice is traditionally cultivated under continuous flooding, requiring larger irrigation water volumes compared to non-ponded crops. In the framework of the MEDWATERICE project (https://www.medwaterice.org/), innovative irrigation methods to reduce irrigation water use and other rice environmental impacts were experimented and benchmarked to the traditional wet-seeding and continuous flooding (WFL) in seven case studies (CSs) representative of different rice agroecosystems in five Mediterranean countries. The most promising irrigation options for each CS were selected with the support of local Stake-Holder Panels, and tailored to site-specific conditions. Alternate wetting and drying (AWD), dry-seeding and delayed flooding (DFL), reduction of irrigation discharge input/output (WIR), hybrid irrigation (HYBRID), sprinkler irrigation (SPRINKLER), surface drip irrigation (DRIP) and subsurface drip irrigation (SDI) were investigated. Results suggest that AWD, DFL and WIR, which are flooding techniques rather simple to implement, might be sound alternatives to WFL leading to an increase in Water Productivity (WP) and safeguarding the yield production. Both SPRINKLER and HYBRID resulted in an increase in WP of about 50% while maintaining or increasing the yield. DRIP and SDI showed a great potential in reducing water use, increasing WP up to 260%; however, yield may sometimes be notably reduced. Nevertheless, for each technique and in particular for localized irrigation methods, site-specific conditions must be carefully evaluated to properly select, design and manage irrigation strategies.
Effect of Real-Time Audio Ventilation Feedback Device on Survival Rate and Outcomes of Patients with Out-of-Hospital Cardiac Arrest: Prospective randomized controlled study. [Address of organization]
Authors: Gu Ji Jae , Dong Lee Eun , Deok Jang Yun , Weon Kim Yang , Hun Kang Ji , Song Seo Yong , Sang Yoon Yoo , Kang Han
Published: August 2023

Background The purpose of this study was to conduct the effect of real-time audio ventilation feedback on the survival of out-of-hospital cardiac arrest(OHCA) patients during advanced cardiac life support(ACLS) performed by paramedics.Methods This study was a prospective randomized controlled study in Busan, South Korea from July 2022 to December 2022.The patients of this study were 121 aged 19 years or older who were transferred to the study institution excluding 91 patients who withholding CPR under doctor's direction and 'Do not resuscitation (DNR) state among 212 adult CA patients. OHCA patients were randomly assigned to compare clinical prognosis using a randomized a general manual defibrillator (NVF) group (N = 58) and a manual defibrillator with audio ventilation feedback (AVF) group (N = 63). To verify the primary outcome, the cerebral performance category (CPC), return of spontaneous consciousness(ROSC), 30 hours survival, and survival discharge were compared. And multivariate logistic regression was conducted to analyze the association of us between the audio-feedback manual defibrillator (AVF) and the ROSC of OCHA patients.Results This study analyzed 121 patients among 212 OCHA patients. The ROSC (AVF group: 32{26.4%} vs. NVF group: 21 {17.3%}), 24-hour survival (AVF group: 24 {19.8%} vs. NVF group: 11 {9.0%}), and survival discharge (AVF group: 12 {9.9%} vs. NVF group: 6 {4.9%}) were higher AVF group than NVF group. But, analyzed CPC scores in surviving patients between the two groups, there was no significant difference (AVF group:4.1 ± 1.23 vs. NVF group: 4.7 ± 1.23, p = 1.232). Multivariate logistic regression analysis showed that the use of AVF was associated with a higher ROSC (odds ratio {OR}, 0.46; 95% confidence interval {CI}, 0.23–0.73; P < 0.01) and higher survival at 30 hours (OR, 0.63; 95% CI, 0.41–0.98; p = 0.01).Conclusion The use of the audio ventilation feedback has been associated with a higher ROSC and higher survival at 30 hours after CA.
Develop a fresh water production method from atmosphere
Authors: Amin Sameh A. Salaheldein , Hassan Mohamed , Elaraby Hossam
Published: August 2023

Fresh water scarcity represents a major world challenges, in addition, the water consumption is increasing with population growth and evaporation due to global climate changes. Furthermore, seawater desalination is considerably cost, requires additional energy to extract it, and negatively affecting water quality. The modern technologies adopted deferent methods to extracting the fresh water from the atmosphere. This work aims to contribute in solving this scarcely fresh water problem through, condensing the humidity in the air and transform it to fresh water. The proposed system is integrated into three parts; mechanical, electrical, and water treatment with filtration unit. The mechanical system consists of a refrigerant cycle with a compressor capacity of 1.5 horse power. The electrical system is responsible of controlling the mechanical system through the Arduino Uno circuit and relay. The filtration system is used to remove sediments and contaminants from the harvest water. The water treatment unit is used to supply the filtered water with the required additives of minerals to transform the distilled water to fresh drinkable water. The system design takes the energy efficiency into account. The system behavior is analyzed, taking into account real climatic conditions of Egypt. Preliminary calculations show that the water extracted from air by condensation is ranged from (8.25 to 12) litters during six operational hours per day. The produced quantity of fresh water can be support the needs from three to four persons per day. The total saving of produced water from the proposed system compared with the price of water in the market is 80,416.8 L.E per year.
A Fast Image Matching Algorithm Based on Locality-sensitive Hashing
Authors: Song Zhijun , Li Wei , Song Yuping , Sun Jinhua , Zhuang Weiwei
Published: August 2023

The progress of Internet technology and the portability of mobile communication equipment have provided essential convenience for building an information society. Today, with networked and digital platforms as an important way of socializing, the information carrier is more based on images, videos, etc. The explosive growth of these multimedia data poses a huge challenge to efficient data storage and fast information retrieval. We design an algorithm combining Locality-sensitive Hashing (LSH) and Vision Transformer (ViT) to greatly improve the image matching rate and accuracy, and the algorithm is called ViT-LSH. The principle of LSH is to form the same hash value for points with similar distances in the data set. The results show that the LSH algorithm reduces space consumption and improves query processing efficiency compared with the other five schemes. Therefore, the LSH algorithm can help to quickly get the approximate nearest neighbor query results in a probabilistic manner, thereby ensuring the accuracy of the query results and the efficiency of time and space. The ViT divides the image into fixed-size image blocks ( Patch), uses Linear projection to project the Patch flatten to the specified dimension, gets the Tokens sequence, and adopts the sequence as the input of the feature to realize a new segmentation mode. The ViT does not employ down-sampling so that the image resolution is not reduced. The modeling of global information is a new semantic segmentation mode. The steps of ViT-LSH are as follows: first, preprocess the image, such as denoising, then segment the image, then extract features by ViT, and then reduce features' dimension. The LSH performs hash coding on the image features. After calculating the image's hash code, the image's similarity can be directly calculated by the Hamming distance, sorted according to the similarity, and the matching results are obtained. The experimental results exhibit that ViT-LSH can greatly enhance the efficiency and accuracy of image matching.
Study and Development of Image Caption Generation using Various Encoders for Different Image Categories
Authors: Namdev Anuja , Reddy S. R.N.
Published: August 2023

Images can act as the source of information or way of communication. Captioning an image by machines in a manner such that it conveys the true meaning is considered the most difficult task. It is indeed a process of deep analysis and most researched area. This paper presents a comparative analysis of different deep learning models such as Inception V3, Resnet50 and VGG16 based on a novel image captioning methodology applied on different picture categories. The hybrid approach is developed to get high BLEU score for each input images. The data set generation, implementation of hybrid approach, and the challenges along with the future work are discussed.
Scaling of electrical relaxation behaviour of polymer mediated spinel Zn Fe2O4
Authors: Chouhan Harsha , PANDA MAHESWAR
Published: August 2023

In this work, the synthesis of ZnFe2O4 (ZF) through mediation of different polymers e.g., Polyvinyl alcohol (PVA), Polyvinylpyrrolidone (PVP) and Polyethylene glycol (PEG) were studied. The structural, micro-structural, thermal and dielectric properties were investigated. Structural characterization, XRD through Rietveld refinement confirms its face centred cubic structure. The thermal analysis of ZF through TGA /DSC signified the stability of ZF. FTIR gave the confirmation regarding the functional group associated with ZF. The Dielectric measurements were carried out by varying the frequency from 20Hz to 2MHz, the dielectric constant decreases with increase in frequency & Tanδ shows highly decrement values. The scaling of relaxation behaviour have been rigorously analysed through Impedance, Modulus and Conductivity Spectroscopy in the temperature and frequency range of 30˚C-200˚C, 20Hz - 2MHz respectively. Scaling of parameters shows the temperature independent relaxation behaviour. Modulus spectra verified the KWW function to be prevailing in ZF as function of temperature/frequency. The AC conductivity behaviour is attributed to small polaron hopping & also satisfied with Jonscher’s universal power law. Same Activation energy of around 0.5eV is found from Arrhenius fitting of Impedance, modulus & conductivity variation as a function of temeperature. The non-coincidences of the Nyquist plot of the ZF induced through different polymers confirm the non-Debye relaxation and the distribution of relaxation times being dependent over the various temperature range of study.
An Efficient Technological based approach for the Organoleptic p arameter Evaluation of Traditional (Siddha) Medicine
Authors: FLORENCE J. REJULA , SUJAPRIYADHARSINI S.
Published: August 2023

This paper presents an effective organoleptic parameter evaluation technique to evaluate the churna (Siddha Medicine). The image processing and analysis techniques has been employed to identify the colour and size of the particles present in the churna. This proposed method of evaluation technique can be used as a data-fusion-based quality assurance method instead of existing manual evaluation methods. Most of the Siddha medications though effective, it is not standardized. So there is a need for standardization and evaluation techniques. Churnas are discriminated by classifying the colour values and particle sizes using machine learning techniques such as the Support Vector Machine (SVM) and Random Forest (RF) classifiers separately. The performance of the RF Classifier excels the SVM Classifier in churna identification with greater accuracy, sensitivity, specificity, precision and f1 score.
Alteration of Postural Stability after Cerebrospinal Fluid Tap Test in Patients with Idiopathic Normal Pressure Hydrocephalus
Authors: Park Eunhee , Lee Sanghyeon , Jung Tae-Du , Park Ki-Su , Lee Jong Taek , Kang Kyunghun
Published: August 2023

Background
In patients with idiopathic normal pressure hydrocephalus (iNPH), the characteristics of balance disturbance are less understood than those of gait. We examined the changes in postural stability after the cerebrospinal fluid tap test (CSFTT) during quiet standing. Furthermore, we explored the relationship between frontal lobe function and the amount of spontaneous body sway.
Methods
All patients with iNPH underwent CSFTT and were evaluated using a frontal assessment battery (FAB) and center of pressure (COP) using a force plate during quiet standing before and after CSFTT. After COP measurement, we calculated COP parameters using time and frequency domain analysis. We determined whether there were alterations of COP parameters before and after CSFTT and the relationship between FAB and COP parameters using SPSS.
Results
In total, 72 patients with iNPH were recruited, and 56 patients who positively responded to CSFTT were finally included. Following CSFTT, there were significantly improved COP parameters using time domain analysis (velocity of COP, vCOP, p = 0.002; root-mean-square of COP, p = 0.032; turn index, p = 0.017; torque, p = 0.003; base of support, BOS, p = 0.014) compared to before CSFTT. In COP parameters using frequency domain analysis after CSFTT, we observed decreased power spectral density (PSD) values in the anteroposterior (peak value, p = 0.049; average value, p = 0.030) and mediolateral (peak value, p = 0.003; average value, p = 0.028) directions at low-frequency oscillation, below 0.5 Hz. In addition, FAB scores were negatively correlated with the vCOP (r = − 0.359, p = 0.007), BOS (r = − 0.302, p = 0.025), and the peak PSD value (r = − 0.464, p = 0.002) and average PSD value (r = − 0.424, p = 0.004) in anteroposterior direction for iNPH patients, respectively.
Conclusions
In patients with iNPH who responded to CSFTT, spontaneous body sway during quiet standing improved after CSFTT. The increased spontaneous sway is associated with impaired frontal lobe function, which may be linked to postural control circuits in patients with iNPH.
Multiple Roles and Prognostic Significance of Kinesin Superfamily Members in Gastric Cancer
Authors: Zhong Qiangqiang , Cao Jiali , Hong Wenbo , Xiong Lina , Xiong Zhifan
Published: August 2023

In recent years, although there has been a decline in the incidence and mortality rates of gastric cancer, it continues to represent a substantial burden on both the human healthcare and society at large. The challenges in early diagnosis of gastric cancer are attributed to its invasive nature and the absence of specific biomarkers. Kinesin family members (KIFs) have emerged as crucial contributors to tumor development. In this research, we explore a dataset acquired from the TCGA to investigate the potential value of KIFs in gastric cancer (GC). Initially, we explored the mutational features of KIFs. Then, in order to clarify their putative biological roles, we selected KIFs that were differentially expressed and carried out GO functional annotation and KEGG pathway analysis. Utilizing Cox regression analysis, we carried out anticipating models relied on the signatures of four KIFs (KIF3C, KIF17, KIF24, and KIFC3). The results revealed that our risk score derived from these models acts as an independent prognostic variable for GC. Additionally, a nomogram was developed to evaluate the outlook of patients with GC. The observed association between the risk score and infiltration of immune cell indicates that the four KIFs signatures could have a crucial influence on the immune microenvironment of GC. To summarize, our investigation revealed the possible molecular pathways linked to KIFs in GC and constructed a predictive framework that shows potential in directing individualized therapy and prognostic evaluation for GC individuals.
Nicotine-based Interventions for Adult Smokers with Diabetes: A Systematic Review
Authors: Haseen Farhana , Rahman Nafis , Hossain As-Saba , Rana Sohel , Chowdhury Asif Moinur , Mahmud Hasna Heena , Coyle Joanne , Notley Sophie , Barnard Gabriel , McKeganey Neil
Published: August 2023

Purpose
Continuing to smoke or starting to smoke after a diagnosis of diabetes is associated with increased health complications, decreased treatment efficacy, and worse survival outcomes. However, the extent and effectiveness of smoking cessation services among patients with diabetes are poorly understood. Nicotine replacement is one of the available interventions to aid smokers in achieving smoking cessation. This systematic review aimed to provide comprehensive evidence on the effects of nicotine-based interventions to support smoking cessation in diabetic patients.
Methods
Electronic searches were carried out on the following databases: Medline, Embase, and Cochrane Library up to November 2022. Searches were supplemented by trial registries, references from identified studies, and review articles. Studies were included if nicotine was used to deliver a smoking cessation intervention and if the impact of the interventions was reported for diabetic patients. All articles were independently screened, selected, extracted, and assessed for quality. Narrative data synthesis was conducted due to heterogeneity.
Results
Sixteen studies reporting 12 trials met the inclusion criteria, including randomized controlled trials (n = 12), one cluster randomized trial, one non-randomized intervention trial, and two before-after design studies. Of the sixteen studies selected, eight studies exclusively assessed diabetic patients, and eight assessed patients with multiple comorbidities, in which diabetic patients were a subgroup of the total sample. Four studies reported interventions with nicotine that increased cessation rates significantly among the intervention group patients compared to the control group at six-month or twelve-month follow-ups. One trial reported a significant reduction in the self-reported number of cigarettes smoked/day in the intervention group compared to the control. Additionally, there was a trend toward positive changes in levels of biomarkers of glucose control and metabolic outcomes with the use of nicotine-based interventions.
Conclusion
Nicotine, with/without behavioral support, appears to increase smoking abstinence in those diagnosed with diabetes without making a significant negative clinical impact. However, data is limited to identifying the optimal form of nicotine or effective intervention for this population. Additionally, there is no evidence of efficacy in smoking cessation interventions with next-generation tobacco harm-reduction products among people with diabetes.