bluuebunny/crossref_metadata_2025 huggingface dataset:
People's Acquisition, Co-construction and Exchange (ACE) of healthcare knowledge in local communities across social networks influencing their decision-making to help themselves, their families, and community members to access health services: A scoping review.
Authors: Bhowmick Anamitra , Zande Marieke Van Der , Harris Prof. Rebecca
Published: December 2024

Introduction:
Local people's knowledge influences healthcare service utilisation, but the literature on people's knowledge-seeking and sharing about different health services across social networks is patchy and not well integrated. This scoping review was undertaken to map how different studies report health service (healthcare)-related knowledge-seeking or sharing in social circles and to identify evidence gaps for further research.
Method
Levac's enhanced scoping review framework was adapted to develop a comprehensive electronic search strategy. Four electronic databases-Medline, Web of Science, PsychINFO, and CINAHL, were searched. Grey literature was also searched. Two independent reviewers assessed around 5% of titles and abstracts. The data was extracted and summarised following title, abstract, and full-text screening.
Results
The review included 14 quantitative, 23 qualitative, 2 mixed-method studies and one report. More studies (n = 29) have been conducted in high and upper-middle-income countries than lower-middle and low-income countries (n = 9), with studies based in the USA (n = 17) the most common. Knowledge related to immunisation services was the most explored area (n = 15), followed by general, maternal and oncological services. Studies show healthcare-related knowledge was sought, acquired, co-produced, shared and diffused in a variety of environments, including urban, rural, and online communities, with women featuring as an essential source of knowledge (n = 19) in varying circumstances. Wide-ranging theories were identified in the included studies, explaining that people's knowledge is shaped by their social networks. However, the concept of people's healthcare-related knowledge was not distinctly defined across the included studies but as a component of general health literacy. Only two studies investigated health service-related knowledge exclusively at interpersonal and community (meso) levels. People's health service-related knowledge is not considered a distinct entity.
Conclusion
People in local communities co-produced, shared, transmitted, or suppressed knowledge about various health services with the support of informal networks, mostly family and friends, combined with mass media sources. Therefore, people's healthcare knowledge is not an individual asset but a shared resource among their social circles. It is multifaceted and acquired from diverse sources available in the local communities, not limited only to lay accounts of using healthcare services.
Assessment of the Environmental Situation of Some Heavy Metals for Selected Roadside Dust in Basrah Governorate, Southern Iraq
Authors: Al-Taie Iqbal Oufi , Darweesh Hanan Abdulqader , Al-Fraji Yasmin Ibraheem , Al-Najari Nael Abdulimam
Published: December 2024

Basrah Governorate is one of the economically important governorates in southern Iraq, as it represents the headquarters of international oil companies. However, it is severely polluted, particularly with petroleum chemicals and hydrocarbons. The purpose of this paper was to assess the environmental state of a few selected sites within the Basrah Governorate and to provide a baseline for managing urban soil pollution and reducing potential environmental hazards. The study gathered roadside dust samples from six sites in the Basrah Governorate: Al-Garma, Sa,ad Square, Al-Tanumah, Al-Shuaiba, Al-Faw, and Al-Zubair. Heavy metal concentrations were measured (nickel, lead, cadmium, and chromium) in these soils; the contamination factor (CF) was calculated, and the geoaccumulation index (Igeo) was then computed to evaluate the soil contamination and link the pollution by heavy metals to potential sources. The results indicated that the nickel, lead, cadmium, and chlorine concentrations are higher than the usual limit in Al-Shuaiba area because of its closeness to oil wells and places of extraction. Additionally, it was discovered that Al-Zubair and Al-Shuaiba have significant cadmium pollution using the contamination factor. The results also show that the geoaccumulation index indicates that there has been severe lead, chromium, and nickel accumulation in all studied locations as a result of the area's rapid and uncontrolled urban development.
Enhancing Spatial Reasoning in Large Vision-Language Models
Authors: Tao Shiquan , Wongsawat Arthit
Published: December 2024

In this paper, we present a novel approach, Spatial-Aware Language Enhancement (SALE), designed to improve the spatial reasoning capabilities of large language models (LLMs) using structured textual descriptions, without the need for visual inputs. Spatial reasoning is critical for understanding object relationships, navigation, and scene layouts in applications such as robotics and autonomous systems. Despite significant advancements in vision-language models (LVLMs), existing models still struggle with spatial tasks, especially when reliant solely on textual data. To address this, we propose a two-phase training strategy involving Spatial Description Pre-training (SDP) and fine-tuning on an enhanced benchmark dataset, SpatialEval+. Our experimental results demonstrate that SALE achieves state-of-the-art performance across various spatial tasks, outperforming existing models like GPT-4 and GPT-4+BLIP, while also being more resource-efficient. Further analysis, including ablation studies and human evaluation, confirms the effectiveness of our approach, indicating its potential for real-world applications where efficient and accurate spatial understanding is required.
Gegeneinander – Nebeneinander – Miteinander?
Authors: Knaus Thomas
Published: December 2024

Wir kommunizieren und kooperieren in medialer Form auf digitaler Basis. Die digitale Basis erweitert mediale Funktionen und ermöglicht so, dass alle Menschen zu medial und technisch Handelnden werden. Medienkompetenzförderung bleibt damit unverzichtbar, sie gewinnt – gerade in andauernden Wandlungsprozessen – weiter an Relevanz. Auch handlungsorientierte Praxisansätze sind aktueller denn je, zumal sie auch zur Förderung technischen Grundlagenwissens und informatischer Bildung herangezogen werden könnten. Medienpädagogische Fragen haben also Konjunktur. Dennoch sollte die Medienpädagogik ihren interdisziplinären Blick auch um technisch-gestalterische Disziplinen erweitern, da sie nicht (mehr) ausblenden kann, dass nicht nur potentiell alle Menschen, sondern auch die digitaltechnische Basis sowie eingeschriebene und selbstlernende Handlungsvorschriften die mediale Oberfläche beeinflussen. Im Beitrag wird diskutiert, warum und worin Medienpädagogik und Informatik in Forschung und Praxis voneinander profitieren können.
Dr. phil. Thomas Knaus ist Professor für Erziehungswissenschaft mit dem Schwerpunkt Medienpädagogik und Leiter der Abteilung Medienpädagogik an der PH Ludwigsburg, Wissenschaftlicher Direktor des FTzM in Frankfurt am Main und Honorarprofessor am Fachbereich Informatik & Ingenieurwissenschaften der Frankfurt UAS. Seine Forschungsschwerpunkte sind Medienpädagogik und Bildungsinformatik. Er ist Mitglied des Lenkungskreises von KBoM! sowie der GI, Mitglied des Bundesvorstands der GMK und Sprecher der Fachgruppe Qualitative Forschung.
Hofmann, Jana (2018). Medienstress durch Smartphones? Eine quantitative und qualitative Analyse. Köln: Herbert von Halem Verlag, 264 S., 32 €.
Authors: Neuleitner Dana
Published: December 2024

Wir sind heute ständig online und über das Internet mit der Außenwelt verbunden – alles muss möglichst schnell und effizient abgearbeitet werden und beansprucht unsere Auf­merksamkeit. Das kann auf Dauer zu Stress und Apathie führen, konstatiert die Autorin Jana Hofmann. In ihrer Promo­tionsstudie Medienstress durch Smartphones? befasst sie sich mit diesem Phänomen der Di­gitalisierung und stellt sich der Frage, welche Faktoren eine exzessive Smartphone-Nut­zung auslösen können. Dabei verknüpft sie sozialpsychologi­sche und kommunikationswis­senschaftliche Ansätze.
Die Publikation setzt sich zu­nächst mit der Entwicklungs­geschichte der Medien ausein­ander bis hin zu den heutigen digitalisierten Lebenswelten, in denen paralleles Medienhan­deln selbstverständlich ist. Die hieran anknüpfenden medien­theoretischen Überlegungen zeigen eine Doppelrolle der Medien: Sind sie bei übermä­ßiger Verwendung zum einen ein Stressfaktor, können sie andererseits zur Stressbewäl­tigung genutzt werden. Hof­manns Forschungsergebnisse offenbaren, dass sich Nutzende über diese Dualität der Effekte durchaus im Klaren sind und Smartphones nur dann zum Stressfaktor werden, wenn sie nicht zum reinen Zeitvertreib genutzt werden. Medienstress entstünde demnach, wenn Anwendende mehrere Dinge gleichzeitig erledigen müssen, um zeitlich effizient arbeiten zu können. Untersucht wird auch der Zusammenhang zwi­schen Bildung und chronischen Bewältigungsschwierigkeiten sowie das Empfinden von Zeit­verlust durch die Smartphone- Nutzung. In der Fokussierung auf negative Wirkungsweisen der Nutzung, lässt die Un­tersuchung mögliche positi­ve Effekte weitgehend außer Acht – obwohl die Befragten diese zum Teil klar benennen konnten. Auch die Frage nach möglichen Bewältigungstakti­ken bleibt zudem offen. Eine Folgestudie, in der die unter­repräsentierten Bevölkerungs­schichten mit Haupt- oder Realschulabschluss und über 50-Jährige stärker berücksich­tigt werden, wäre in Betracht zu ziehen. Insgesamt zeigt sich jedoch, dass je nach Art und Kontext der Mediennut­zung das befürchtete Stressausmaß unterschiedlich stark ausfällt und relativiert werden kann. Der Band eignet sich für eine kritische Reflexion durch medienpädagogische Fachkräfte, aber auch für all die­jenigen, die ihr Smartphone- Verhalten hinterfragen wollen. Durch die Verknüpfung der quantitativen und der qualita­tiven Analyse sowie einen aus­geprägten Theorieteil bietet die Arbeit fundierte Einblicke in das junge Forschungsfeld Medienstress.
Ingold, Selina/Maurer, Björn (2021). Making im Schulalltag. Konzeptionelle Grundlagen und Entwicklungsschritte. München: kopaed. 454 S. 24,80 €.
Authors: Struckmeyer Kati
Published: December 2024

Selina Ingold und Björn Maurer haben einen umfassenden Aufschlag zum Thema Making im Schulalltag gemacht. Nicht erst seit dem teilweise unfreiwilligen, coronabedingten Digitalisierungsschub ist das kreative Tüfteln und Erfinden mit analogen und digitalen Verfahren auch in der Schule angekommen. Hier werden immer häufiger MakerSpaces als Lernumgebungen eingerichtet, wo Schüler*innen Ideen entwickeln und mithilfe von digitalen Werkstoffen und Fabrikationstechnologien Produkte designen können. Neben dem Erwerb von Fachwissen geht es dabei insbesondere um überfachliche Kompetenzen wie Kreativität und Kollaboration. Außerdem sollen zukunftsrelevante persönliche Eigenschaften wie Offenheit, Beharrlichkeit, Improvisationsfähigkeit und Risikobereitschaft entwickelt werden.
Das Buch beschreibt am Beispiel einer Primarschule in der Schweiz, wie Making im Rahmen eines partizipativen Prozesses in Zusammenarbeit mit Lehrpersonen und Schüler*innen in den Schulalltag integriert werden kann. Die Basis hierfür bildet ein dreijähriges Design-Based Research Projekt, innerhalb dessen zunächst die konzeptionellen Grundlagen für kreatives und mündiges Making erarbeitet werden. Anschließend wird entlang der neun Handlungsfelder Making-Kompetenzen, Maker Mindset, Didaktik, Lernbegleitung, Making-Curriculum, Raumgestaltung, Raumausstattung, Weiterbildung, Organisatorische Einbindung aufgezeigt, welche Entwicklungsschritte hin zum schulischen MakerSpace durchlaufen und welche Designentscheidungen von den Akteur*innen getroffen wurden.
Neben den detailreichen Ausführungen und Grundlagen machen auch vielfältige Grafiken, Bilder und Zitate der Projektbeteiligten allen, die kreativ mit Kindern und digitalen Geräten arbeiten, Lust, direkt mit dem Making zu starten. Auch ein Blick auf die projektbegleitende Website lohnt: https://makerspace-schule.ch/.
Zur empirischen und theoretischen Kritik der Datensouveränität anhand der Smart-Speaker-Nutzung
Authors: Waldecker David
Published: December 2024

Der Beitrag kritisiert die Konzepte der digitalen bzw. der Datensouveränität. Beide werden unter anderem verwendet, um eine Stärkung der Nutzenden von digitalen Diensten gegenüber Staat und Online-Oligopolen zu fordern. Zur Kritik des Konzepts wird sowohl auf eine praxistheoretische Perspektive auf Daten und auf eine kritisch-theoretische Perspektive (im Sinne Adornos und Horkheimers) auf den Souveränitätsbegriff als auch auf qualitative Studien zur Smart-Speaker-Nutzung zurückgegriffen.
Die Rolle des Hypoxie-induzierbaren-Faktor 1α in der Pathogenese der Leberzirrhose und des Akut-auf-chronischen-Leberversagens
Authors:   , El Bali Nihad
Published: December 2024

Als einer der führenden Todesursachen weltweit repräsentiert die Leberzirrhose das Endstadium verschiedenster chronisch-progredient verlaufender Lebererkrankungen. Als Leberzirrhose wird der Endzustand eines bindegewebignarbigen Umbaus des Leberparenchyms aufgrund einer chronischen Schädigung dessen bezeichnet. Zu den häufigsten Ursachen einer Leberzirrhose gehören chronischer Alkoholabusus und chronisch verlaufende virale Hepatitiden.
Geht eine akute Dekompensation der Lebererkrankung mit multiplem Organversagen einher, spricht man von Akut-auf-chronischem-Leberversagen (ACLF).
Das ACLF geht mit einer deutlich erhöhten Mortalität einher und die Therapieoptionen sind limitiert. Die pathophysiologischen Mechanismen der Erkrankung sind noch weitgehend unverstanden, weshalb die Erforschung dieser im Vordergrund der heutigen ACLF-Forschung steht.
Im Rahmen dieser Arbeit wurde die Rolle von HIF-1 im Geschehen des ACLF beschäftigt. In der Literatur wird HIF-1 bereits mit einer Zunahme der Fibroseprogession bei chronischer Leberschädigung in Nagetieren assoziiert, weshalb ich die molekularen Mechanismen dahinter vertiefend untersucht habe.
Eine chronische Leberschädigung bzw. ein ACLF wurde hierfür in verschiedenen Nagetiermodellen nachgebildet. Anschließend wurde die HIF-1α-Aktivität mittels qRT-PCR intra- sowie extrahepatisch untersucht. Hier sahen wir eine intrahepatische Erhöhung der mRNA-Level von HIF-1α und seinen Induktoren.
Western Blots bzw. die Untersuchung nachgeschalteter Signalwege dienten als Nachweis des Proteins. Die Immunhistochemie erlaubte die Zuordnung der HIF-1α-Expression zu den Hepatozyten. Aus unseren Untersuchungen geht hervor, dass HIF-1α auch hypoxieunabhängig über die Schlüsselproteine NF-κB und STAT3 in verschiedenen Nagetiermodellen in Leberzirrhose und ACLF intrahepatisch von Hepatozyten erhöht exprimiert wird. Mit unserer Arbeit konnten wir den theoretischen Rahmen, der zum Verständnis der Rolle von HIF in Zirrhose und ACLF beträgt, weiter vervollständigen. Dies stellt eine wichtige Grundlage für die Entwicklung von Therapien und der Identifizierung von diagnostischen bzw. prognostischen Faktoren dar.
Validierung eines Vorhersagemodells hinsichtlich des organüberschreitenden Stadiums von >= pT3 bei cT1 klarzelligen Nierenzellkarzinomen
Authors:   , Dietl Hanna
Published: December 2024

In der vorliegenden Arbeit nahmen wir erstmals eine externe Validierung des Risikokalkulationsmodells von Nocera et al. zur Vorhersage eines >= pT3 ccRCC bei Patienten mit cT1 Nierentumoren vor. Dazu wurde eine Studienkohorte aus 288 Patienten nach operativer Therapie bei cT1N0M0 ccRCC am Universitätsklinikum in Frankfurt am Main, Deutschland, untersucht. Die zu erhebenden Parameter stellten das Alter zum Zeitpunkt der Diagnose, die Tumorgröße in cm, die Randlokalisation des Tumors (medial oder lateral), die exophytische Wachstumsrate (< 50 % oder >= 50 % oder total endophytisch) und die polare Beteiligung dar.
Es konnte gezeigt werden, dass in unserer externen Validierung eine Vorhersagegenauigkeit von 76,6 % für das Vorliegen eines >= pT3 Tumorstadiums bei cT1N0M0 ccRCC erreicht wurde. Dieser Wert bestätigt die vorangegangene Publikation von Nocera et al. bei der in einer Studienpopulation von 236 Patienten mit einer Genauigkeit von 81 % bei 14 Patienten ein höheres Tumorstadium vorhergesagt wurde. Somit konnte das ursprüngliche Nomogramm von Nocera et al. für die klinische Anwendung validiert werden.
Ungeachtet der Limitationen, die im Wesentlichen denen der initialen Publikation entsprechen, konnte die Relevanz des Risikokalkulationsmodells für die Vorhersage für ein >= pT3 Tumorstadium in klinischen Beispielen dargelegt werden. So lässt sich der Risikokalkulator im klinischen Alltag einfach anwenden und ist je nach Nutzer individualisierbar. Zudem lässt sich durch das Modell die klinische Dringlichkeit einer Behandlung besser einschätzen als nur anhand des Tumordurchmessers. Das Modell erlaubt das individuelle Risiko eines höheren und lebensbedrohlicheren Tumorstadiums zu ermitteln und die Behandlung gegebenenfalls zu priorisieren. Ferner lässt sich durch dieses Modell das Aufklärungsgespräch zwischen Arzt und Krebspatient verbessern. Durch eine höhere Transparenz kann der Patient mit einem hohen Risiko für ein >= pT3 Tumor schon vor der chirurgischen Intervention auf eine mögliche adjuvante Therapie sensibilisiert werden. Dies ermöglicht es bereits beim Patientengespräch eine solide Vertrauensbasis zu schaffen, indem der Arzt von vornherein das individuelle Risiko des Patienten einschätzen kann und diesem die Gelegenheit gibt, besser mit seiner Erkrankung zu leben und sich mit möglichen Konsequenzen auseinanderzusetzen.
Himalayan Leucogranites: A Geochemical Perspective
Authors: Wang Ze-Zhou , Teng Fang-Zhen , Zeng Lingsen , Liu Zhi-Chao
Published: December 2024

The geochemical characterization of Himalayan leucogranites offers important insights into both their petrogenesis and Himalayan orogenic processes. Himalayan leucogranites are characterized by strongly peraluminous compositions that are comparable to melts derived from anatexis of sedimentary rocks. Their radiogenic (Sr, Nd, and Hf) isotopic compositions point to metasediments from the Higher Himalayan Sequence of the Indian plate as the primary source rocks, with minor contributions from other lithologies. Himalayan leucogranites display considerable variability in trace element ratios (e.g., Rb/Sr, Nb/Ta, Zr/Hf, and Eu/Eu*) and significant fractionation of non-traditional stable isotopes (e.g., Mg, K, Zn, Rb, and Ba), which provide key constraints on the respective roles of source heterogeneity, crystal fractionation, magma–fluid interaction, and crustal melting in their formation.
Escultura y arquitectura en el medio río Mundo en época ibérica: Novedades desde Cercado de Galera (Liétor, Albacete)
Authors: García-López Arturo , Robles Moreno Jesús
Published: December 2024

Se presenta en este trabajo una revisión del conjunto material procedente del yacimiento de Cercado de Galera (Liétor, Albacete), un yacimiento en el valle del medio río Mundo conocido desde el año 1971 gracias al hallazgo casual de esculturas y sillares. El objeto de este es actualizar la base material del sitio, a luz de nuevos descubrimientos, y presentar algunas nuevas posibilidades interpretativas emanadas del estado actual de las investigaciones en Protohistoria peninsular; líneas de trabajo que tanto han cambiado desde que el yacimiento cayó en el olvido en los años 90.
ABSTRACT: This paper presents a revision of the corpus from the site of Cercado de Galera (Liétor, Albacete), a site in the valley of the middle Mundo River, known since 1971 thanks to the casual discovery of sculptures and ashlars. The purpose of this paper is to uptade the material base of the site, in the light of new discoveries, and to present some new interpretative possibilities derived from the current state of research in Peninsular Protohistory. These lines of work have changed a lot since this site fell into oblivion in the 1990s.
PRODUÇÃO DE SUBJETIVIDADE NO CAPITALISMO CONTEMPORÂNEO
Authors: Fortunato Lucas , Galeno Alex , França Fagner
Published: December 2024

A crise que, desde a década de 1970, o capitalismo vem tentando contornar é, além das evidentes crises econômicas e políticas, a crise da subjetividade. Essa é sem dúvida uma problemática fundamental das atuais sociedades que precisa ser analisada e compreendida em toda sua extensão. Acompanhando o ritmo tecnológico, o capitalismo contemporâneo tornou-se, no decorrer dos anos, gradativamente maquinocêntrico. Cada vez mais, os sujeitos são inseridos em circuitos de homens e máquinas conjugados. Na concepção de Gilles Deleuze e Félix Guattari, as sociedades neoliberais, marcadas pelo modo de produção pós-fordista e por um sistema voltado para o consumo, desenvolveram um regime de produção de subjetividade maquínica. Em paralelo à sujeição social, montou-se um regime de servidão maquínica generalizado. Nas atuais sociedades ocidentais, as subjetividades são produzidas na convergência desses dois regimes. Porém, esse processo não ocorre sem resistências. Há que se considerar as subjetivações políticas, caracterizadas pelas rupturas, criações e potências do desejo, que dinamizam micropolíticas irredutíveis aos processos de dominação em vigor. Nesse ensaio, apresentamos algumas reflexões e problemáticas sobre essas questões, principalmente, à luz dos autores Gilles Deleuze, Félix Guattari e Maurizio Lazzarato.
REFORMA E CRISE POLÍTICA NO BRASIL
Authors: Feitosa Gonçalves Hugo
Published: December 2024

Resenha
JOSEPH STIGLITZ E O CAPITALISMO PROGRESSISTA
Authors: Ferreira Nunes Leon Karlos
Published: December 2024

Joseph E. Stiglitz cresceu na era de ouro do capitalismo, nos Estados Unidos, e pôde perceber tudo aquilo desmoronando nas décadas seguintes. Lecionou em diversas universidades e compôs o governo de Bill Clinton como Presidente do Conselho de Assessores Econômicos. Ainda participou do Banco Mundial, primeiro como Vice-Presidente Sênior para Políticas de Desenvolvimento e depois como Economista-Chefe da instituição. Pelos seus estudos sobre negócios e transações com informações assimétricas, o que lhe permitiu identificar variadas falhas de mercado, foi agraciado com o Prêmio Nobel de Economia em 2001. Sendo um autor prolífico, uma de suas mais recentes publicações é Povo, Poder e Lucro – Capitalismo Progressista para uma Era de Descontentamento (2021), em que discorre sobre alguns entraves econômicos dos Estados Unidos e aponta algumas saídas possíveis.
NISE QUE CURA, UM LEGADO A CELEBRAR
Authors: Miguel Marcelo Calderari
Published: December 2024

Nise Que Cura, Um Legado A Celebrar é um poema inspirador que retrata de forma tocante o impacto do trabalho de Nise da Silveira e sua contribuição para a saúde mental. A linguagem poética é fluente e expressiva, com metáforas e figuras de linguagem bem utilizadas para enriquecer as descrições. A escolha das palavras transmite emoção e ressalta a importância da arte e da inclusão na busca pelo bem-estar mental.
No aspecto métrico, o poema segue a estrutura alexandrina, com versos decassílabos bem construídos, mantendo uma cadência consistente ao longo do texto. Isso contribui para a harmonia e ritmo da poesia.
A mensagem do poema é poderosa, ressaltando a grandiosidade de Nise da Silveira e seu legado, além de destacar a relevância da cultura, da empatia e da transformação na promoção da saúde mental.
TRABALHO INTERPROFISSIONAL E PRÁTICAS COLABORATIVAS EM SAÚDE DURANTE A PANDEMIA DE COVID-19
Authors: Soares Fonseca Graciela , Cesira Cassaro Bernarda , Rostirola Borin Emanoeli , Lanzini Maurcio , Klabunde Carabagialle Viridiane , Rogel de Souza Carolina , Schneider Pires Fabiana
Published: December 2024

Introdução: desde 2020, muito se tem discutido sobre a organização das práticas de saúde para enfrentamento da covid-19, incluindo a revenção e recuperação das dezenas de sequelas atribuídas aos casos de doença na população. Diante desse contexto, é necessário desenvolver ações de vigilância epidemiológica de prevenção e promoção de saúde em conjunto com a Atenção Primária à Saúde. Objetivo: analisar o trabalho interprofissional e colaborativo na Atenção Primária à Saúde Atenção Básica frente aos agravos em saúde e a inter-relação com a pandemia de covid-19. Metodologia: estudo de abordagem qualitativa, do tipo estudo de caso, desenvolvido em uma Unidade Básica de Saúde localizada em um município de médio porte do estado de Santa Catarina. Participaram do estudo trabalhadores dos níveis superior, técnico e médio. A amostra foi definida, por conveniência, pelos dados coletados por meio de Grupos Focais. A análise foi realizada por meio da análise de conteúdo temática. Resultados: emergiram do material coletado as seguintes categorias de análise: concepções de interprofissionalidade e práticas colaborativas; a pandemia de covid-19 e o estímulo ao trabalho interprofissional; principais dificuldades enfrentadas para concretização do trabalho interprofissional durante a pandemia de covid-19. Discussão: a atuação multiprofissional foi vista como positiva, como forma de os profissionais conhecerem mais as demandas dos usuários e o trabalho dos demais colegas, ao passo que a sobrecarga de trabalho, por conta das grandes demandas geradas pela pandemia, comprometeu o trabalho colaborativo dentro e entre as equipes de saúde.
POLÍTICA MACROECONÔMICA EM DESCOMPASSO:
Authors: Feitosa Gonçalves Hugo
Published: December 2024

A partir de uma perspectiva institucionalista estruturalista histórica, Laura Carvalho (2021), em “Valsa Brasileira: do boom ao caos econômico”, construindo uma metáfora referente a dança de origem europeia, mostra em cinco capítulos os passos quais a economia brasileira sai do ritmo e entra em descompasso com o desenvolvimento econômico.
ASCENSÃO PACÍFICA DA CHINA OU NOVA ERA DE CONFLITOS ENTRE POTÊNCIAS?
Authors: De Paula Barbieri André Augusto
Published: December 2024

Nesse artigo buscamos explorar as coordenadas concretas da disputa entre Estados Unidos e China. Examinamos as particularidades desse conflito como uma etapa da nova rivalidade entre potências, dentro do esgotamento do ciclo neoliberal herdado da Guerra Fria. Buscamos realizar um contraponto crítico à tese da suposta multipolaridade benigna, segundo a qual a disputa hegemônica no capitalismo pode se dar sem comoções militares e revolucionárias, e que apresenta a China de Xi Jinping como uma alternativa progressista diante da violência do imperialismo estadunidense. Sustentamos que a eventualidade de um conflito aberto entre ambas as nações, no contexto dessa rivalidade entre potências capitalistas dissimilares, apresenta um quadro retrógrado para a humanidade, e não exibe um campo progressista a defender. Indicamos, portanto, a importância do fator da luta de classes na China e da solidariedade dos seus trabalhadores com os povos oprimidos no mundo como componente irredutível para uma saída independente das políticas levadas adiante em Washington e Pequim.
ENTREVISTA COM CARLOS EDUARDO MARTINS
Authors: De Paula Barbieri André Augusto
Published: December 2024

ENTREVISTA COM CARLOS EDUARDO MARTINS
SIC TRANSIT
Authors: Bastos Octavio
Published: December 2024

o autor se descloca a pé por ruas arborizadas enquanto, imerso em seus pensamentos,  observa o desenrolar de dramas humanos
SUBSUNÇÃO REAL DO TRABALHO AO CAPITAL E PAUPERIZAÇÃO ABSOLUTA
Authors: Trindade Hiago
Published: December 2024

O avanço das plataformas digitais e da chamada “Indústria 4.0” na sociedade contemporânea tem provocado a exponenciação da precarização do trabalho e, como corolário, o aviltamento das condições de existência da classe trabalhadora. Partindo dessa premissa, este texto pretende oferecer subsídios para compreender como a subsunção do trabalho ao capital impacta as relações de trabalho na era do capitalismo digital e seus sujeitos, em especial o precariado. Metodologicamente, além da revisão de literatura assentada no diálogo com autores clássicos e contemporâneos afeitos ao tema, utilizaremos dados secundários, estes provenientes de estudos acadêmicos e matérias de jornais. Assim, o texto conclui destacando que no Brasil, o entendimento do precariado está associado a um novo grau de subsunção real do trabalho ao capital, marcado sobremaneira pelas alterações processadas no modo de produção capitalista, em sua fase imperialista e pelo avanço da pauperização absoluta.
TRABALHO PRODUTIVO, IMPRODUTIVO E FRAGMENTAÇÃO LABORAL NA ERA DA INTELIGÊNCIA ARTIFICIAL
Authors: Tonelo Iuri
Published: December 2024

Este artigo busca refletir sobre o significado da nova reestruturação produtiva que estamos vivenciando a partir das transformações advindas da era da inteligência artificial, concentrando a análise em dois aspectos: as transformações nas formas de produção de valor e a reprodução ampliada do capital resultantes das mudanças morfológicas do mundo do labore; além disso, no interior desse processo, interpretar o movimento de “produtivização” do trabalho (transformar trabalhos improdutivos em produtivos). Para isso, propomos retomar o debate sobre o trabalho produtivo e improdutivo presente na crítica da economia política de Karl Marx, buscando ligar essas bases teóricas com os novos fenômenos e modalidades laborativas. Por fim, propomos enfeixar a reflexão com o debate sobre as “posições estratégicas” do proletariado nesse contexto de aceleradas transformações, compreender as forças que levam à fragmentação de uma classe tão extensa e refletir sobre os desafios colocados para a superação desse problema.
The Potential Role of Enrichment Environment on Plasticity in Alzheimer's Disease Models: Insights About Therapeutic Approaches
Authors: Neves Rodrigo C. , Figueiredo Raquel C. , Faria-Melibeu Adriana C.
Published: December 2024

Alzheimer’s Disease (AD) is characterized by synapse loss and neurodegeneration,
which leads to cognitive and psychiatric symptoms. Researchers worldwide have been studying
therapeutic approaches aiming to induce plasticity and neuroprotection once AD has no cure and
the existing treatments are limited. Environmental Enrichment (EE) is a change in housing conditions
that promotes increased cognitive stimulus. Studies have demonstrated that EE acts as a plasticity
modulator in several conditions and experimental models. In this review, we analyze and discuss
the potential role of EE on plasticity modulation in different animal models but primarily on
AD models. The data were extracted from the PubMed and ScienceDirect databases. The EE was
shown to induce plasticity. LTP and behavior were enhanced in animals under different conditions,
such as the AD model. The mechanisms were related to the glutamatergic system and excitatory/
inhibitory balance. Moreover, many studies have evidenced that EE promotes the upregulation
of BDNF and the synaptic proteins SYN and PSD95. These data also suggest a neuroprotective
function performed by EE in different contexts, such as aging and AD. Therefore, an enriched
environment can be a target of new therapeutic approaches that aim to induce neuroplasticity and
neuroprotection against AD.
Mechanisms Underlying the Attenuating Effects of Bugantang on Liver Fibrosis based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation
Authors: Zhang Taojing , Chang Jia , Zheng Zengle , Chen Guobi , Wu Yiping , Xiang Jinxiang , Chen Jing
Published: December 2024

Background:

Liver fibrosis, a chronic liver disease, threatens people's health, increases
the burden of healthcare, and currently lacks effective treatment measures. Bugantang
(BGT) is a traditional Chinese herbal prescription from Jin Kui Yi with promising potential for
treating liver fibrosis. Despite this potential, the efficacy and mechanism for treating liver fibrosis
remain unclear.

Objective:

To primarily prove the efficacy, predict the active components of BGT, and explore
the mechanism of BGT on liver fibrosis.

Methods:

The liver condition of CCL4-induced mice was examined using hematoxylin and eosin
staining. The targets and active compounds of BGT were sourced from HERB and TCMSP
databases, while the targets related to liver fibrosis were acquired from DisGeNET, Gene Expression
Omnibus, and GeneCards databases. The core targets were identified, and the network
of protein-protein interactions was established. KEGG and GO analyses were performed on
DAVID. Molecular docking and molecular dynamics simulations assessed the active components’
interactions with potential targets.

Results:

A total of 215 targets and 152 active compounds were identified for BGT. The
network analysis identified kaempferol, quercetin, 2-(2,4-dihydroxyphenyl)-7-hydroxy-4Hchromen-
4-one, sitosterol, naringenin, adenosine, plo, and beta-sitosterol as potential key compounds,
and AKT1, MMP9, SRC, TNF, ESR1, NF-κB, and PPARG as potential key targets.
KEGG and GO analyses revealed that the therapeutic effect of BGT on liver fibrosis may be associated
with the PI3K-AKT and MAPK signaling pathways, as well as cell apoptosis, protein phosphorylation,
and inflammation. Molecular docking demonstrated high-affinity binding of the identified
targets to the active compounds. Additionally, molecular dynamics simulation further confirmed
that the bindings of AKT1-beta-sitosterol and MMP9-quercetin exhibited good stability.

Conclusions:

The potential of BGT in alleviating liver fibrosis may be attributed to a combination
of various active compounds, targets, and pathways. These results could support the use of
BGT in treating liver fibrosis and facilitate the development of new drug candidates for this
condition.
Pharmacogenetic Testing in Treatment-resistant Panic Disorder: a Preliminary Analysis
Authors: Fidry Marcos , Zugliani Morena Mourao , do Cabo Mariana Costa , Martins Renan Machado , Gomez Manuella Assad , Faria Clara Gitahy Falcão , Nardi Antonio Egidio , Freire Rafael C.
Published: December 2024

Background

Many pharmacological treatments are considered effective in the treatment of panic disorder (PD), however, about 20 to 40% of the patients have treatment-resistant PD. Pharmacogenetics could explain why some patients are treatment-resistant.

Objective

Our objective was to gather preliminary data on the clinical usefulness of pharmacogenetic testing in this disorder.

Methods

Twenty patients with treatment-resistant PD were included in this observational study and submitted to commercial pharmacogenetic testing. Testing panel included gene polymorphisms related to CYP, genes EPHX1, UGT1A4, UGT2B15, ABCB1, ADRA2A, ANKK1, COMT, DRD2, FKBP5, GRIK4, GSK3B, HTR1A, HTR2A, HTR2C, MC4R, OPRM1, SCN1A, SLC6A4 and MTHFR. Participants received treatment-as-usual for PD before being enrolled in this study, including first-line and second-line medications for PD.

Results

In 30% of the patients, the tests indicated reduced chance of response to the prescribed drug, while they indicated very low serum levels of the prescribed drug in 20% of the subjects. The pharmacogenetic tests predicted reduction of MTHFR enzyme activity in 74% of the patients. ABCB1 gene alleles associated to drug resistance were found in 90% of the samples.

Conclusion

Commercial pharmacogenetic testing failed to predict negative treatment outcome in most patients with PD. The association between treatment-resistance in PD and the genes CYP2C19, MTHFR and ABCB1 deserves further study.
Review: Upcycling Potential for Romaine Lettuce Outer Leaves
Authors: Alemán-Hidalgo David M. , Avena-Bustillos Roberto J. , Klausner Noah , Wang Hongye , Wang Luxin , Milczarek Rebecca , Teran-Cabanillas Eli
Published: December 2024

Worldwide, food losses and waste exert a substantial negative environmental im-pact. The harvesting of Romaine lettuce, for instance, generates significant waste as outer leaves are typically removed from the cores during harvest and left to decompose in the field. Upcycling technologies offer innovative methods to convert these leaves into valuable prod-ucts, enhancing sustainability in food systems. This approach not only mitigates waste during the Romaine lettuce harvest but also reduces contaminants. Furthermore, Romaine lettuce is rich in nutritional value and its phenolic compounds are known for their antioxidant, anti-inflammatory, antilipemic, antidiabetic, and antihypertensive properties. In this review, we ex-plore opportunities for upcycling Romaine lettuce outer leaves and the environmental benefits with consideration of potential contaminants. Understanding the nutritional value and health benefits of Romaine lettuce underscores the importance of sustainable practices in agriculture and food management.
WITHDRAWN: FDA Approvals of Biological Drugs from 2013 to 2022: An Observational Study
Authors: Shukla Ajay Kumar , Misra Saurav , Sarajhna Ashish Kumar
Published: December 2024

The article has been withdrawn at the request of the author of the journal "Applied Drug Research, Clinical Trials and Regulatory Affairs".

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultane-ously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Clinical Application of Pharmacogenomics in the Administration of Common Cardiovascular Medications
Authors: Aslam Faaiq N. , Schneider Artur , Jhawar Nikita , Chirila Razvan
Published: December 2024

Introduction:

Genomic variations among individuals can greatly affect their responses
to different medications. Pharmacogenomics is the area of study that aims to understand the relationship
between these various genetic variations and subsequent drug responses. Many medications
used to optimize cardiovascular health are affected by these genetic variants and these relationships
can subsequently impact dosing strategies in patients.

Objective:

This study aims to review the current literature on the clinical applications ofpharmacogenomics
for commonly used cardiovascular medications such as Warfarin, Clopidogrel,
Statins, Beta Blockers, and ACE-I/ARBs.

Methods:

Databases like PubMed were accessed to gather background information on pharmacogenomics
and to collect data on relationships between genetic variants and subsequent drug
response. Information on clinical applications and guidelines was obtained by accessing the CPIC
and DPWG databases.

Results:

This article describes the most up-to-date data on pharmacogenomics relating to commonly
used cardiovascular medications. It also discusses the clinical application of pharmacogenomic
data as it pertains to medication selection/dosing by detailing current guidelines published by organizations
such as the Clinical Pharmacogenetics Implementation Consortium and the Dutch
Pharmacogenetics Working Group.

Conclusion:

In conclusion, this paper will help medical providers not only better understand pharmacogenomics
but also apply it in their day-to-day practice. Clinical guidelines relating to the application
of pharmacogenomic data were discussed both in text and graphical format, allowing
providers to confidently select medications and adjust doses for common cardiovascular medications
so that patients receive the maximum therapeutic benefit with minimal toxicity.
Predictive Analytics in Recruitment and Selection Practices
Authors: V. Sasirekha , N. Nithyashree , N. Sarulatha
Published: December 2024

Predictive analytics in recruitment and selection analytics in HR are
increasingly important in a competitive job market. The importance of predictive
measures in recruitment and selection analytics provides practical guidance for HR
professionals looking to implement these measures in their organizations. Predictive
measures involve the use of data-driven methods and statistical analyses to identify and
hire the most qualified candidates for a given job. This approach relies on the collection
and analysis of various data points, such as job requirements, candidate qualifications,
and hiring outcomes, to develop models that predict which candidates are most likely
to succeed in the role. By leveraging this information, HR professionals can streamline
the recruitment process, reduce the risk of making hiring mistakes, and improve overall
organizational performance. This article aims to provide the key predictive measures
used in HR analytics to help organizations make better hiring decisions and an
overview of key concepts and benefits associated with predictive measures in
recruitment and selection analytics in HR, along with the challenges and limitations
associated with the use of predictive measures in HR analytics and recommendations
for overcoming these challenges.
Unleashing the Power of HR Analytics: Enhancing People Management Strategies
Authors: Bhati Parulkumari
Published: December 2024

HR analytics can enable organizations to make data-driven decisions that
improve workforce productivity, engagement, and retention. This chapter provides an
overview of the key HR analytics concepts and methods, including data collection and
analysis, data visualization, and predictive modeling. It also focuses on the challenges
and opportunities associated with implementing HR analytics in organizations, such as
data privacy and security concerns and the need for skilled data analysts. Overall, the
article makes a case for HR analytics as a critical tool for driving organizational
success in the modern workplace. The use of HR analytics has become increasingly
important in enhancing people management strategies. This chapter also explores the
potential of HR analytics to transform the way organizations manage their workforce,
from recruitment to retention. By leveraging data and analytics, HR experts can gain an
understanding of their workforce, identify areas for improvement, and make datadriven decisions. This chapter discusses the benefits of HR analytics, including
improved talent acquisition, enhanced employee engagement and retention, and
increased productivity. It also examines some of the challenges organizations may face
when implementing HR analytics, such as data privacy concerns and the need for
specialized skills. Overall, this chapter demonstrates how HR analytics can be a
powerful device for establishments looking to augment their people management
policies.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT BELI ULANG MASYARAKAT MUSLIM KOTA MALANG TERHADAP MIE GACOAN
Authors: Fadhillah Muhammad Ayyub , Noor Iswan
Published: December 2024

Mie Gacoan is a spicy noodle restaurant that was founded in early 2016. Mie Gacoan is now spread in almost all big cities in Indonesia. One of them is Malang City, where Mie Gacoan was founded. In recent years, Mie Gacoan has always been busy with buyers, either eating on the spot or buying via the online application. This research aims to determine the factors that influence Muslim consumers repurchase interest in Mie Gacoan in Malang City using the variables halal certification, EWOM and product quality. This research used a questionnaire by taking 153 respondents. The sampling technique used is a probability sampling technique with a simple random sampling method. The analysis technique used is multiple linear regression analysis. The results of the T test state that the EWOM variable and product quality partially have a positive and significant effect on repurchase interest. Meanwhile, halal certification does not have a significant effect on repurchase intention. The results of the F test show that halal certification, e-wom, and product quality simultaneously influence repurchase interest.
Gezelle, natuur en ‘duurzaamheid’
Authors: Platteau K.
Published: December 2024

Sustainability, a term used by the poet Guido Gezelle as early as 1871, is now a key concept in the environmental debate, such as in the Brundtland Report (1987), which contained an influential definition of sustainable development: ‘development that meets the needs of the present without compromising the ability of future generations to meet their own needs’. This always concerns economic, social and ecological needs. This essay explores Gezelle’s interpretation of sustainability as a theological concept: God is sustainability, His creation is expressed in nature and in the cosmos; nature is the teacher of theology.
De contemplatieve natuurvisie van Thomas Merton
Authors: Bras K.E.
Published: December 2024

In this article I unfold the contemplative vision on nature and the impulse for an ecological ethics of the Trappist monk Thomas Merton. After a short summary of the role of nature in his biography, I explore the sources of his contemplative vision, and then investigate the meaning that nature had for his contemplative life. Silence and solitude in nature makes the heart pure and receptive to perceive the oneness of all creation with the abiding Creator. This deep experience leads to an ethics of preservation of the integrity, stability and beauty of the biotic community
Smjernice za zbrinjavanje bolesnika s vrtoglavicom u hitnoj medicinskoj službi
Authors: Adamec Ivan , Crnošija Luka , Keranović Adis , Abičić Ana , Blažević Nikola , Milivojević Iva , Habek Mario
Published: December 2024

Vrtoglavice su čest uzrok pregleda bolesnika u objedinjenom hitnom bolničkom prijamu. Diferencijalna dijagnoza akutne vrtoglavice može biti izazovna zbog nekoliko razloga: pojam vrtoglavica često se koristi za različite simptome koji uključuju vestibularno oštećenje, ali i sistemske bolesti; diferencijalna dijagnoza vrtoglavice može biti vrlo široka i uključivati centralne i periferne uzroke i često ne postoji specifična dijagnostička pretraga kojom će se potvrditi točna etiologija vrtoglavice u hitnoj službi. Zbog navedenog postoji potreba za smjernicama za zbrinjavanje bolesnika s vrtoglavicom u hitnoj službi. Pristup bolesniku s vrtoglavicom temelji se na anamnezi kojom se procjenjuje o kojoj se skupini vrtoglavica radi na temelju utvrđivanja vremena nastanka, trajanja vrtoglavice i mogućeg provocirajućeg čimbenika. Na temelju navedenog razlikujemo: (1) akutni vestibularni sindrom, (2) izazvani epizodni vestibularni sindrom te (3) spontani epizodni vestibularni sindrom. Unutar tih skupina vrtoglavica razlikujemo po dvije najčešće diferencijalne dijagnoze na temelju daljnjeg pregleda: (1) vestibularni neuritis i infarkt malog mozga, (2) benigni paroksizmalni pozicijski vertigo i centralnu pozicijsku vrtoglavicu te (3) vestibularnu migrenu / Menierovu bolest i tranzitornu ishemijsku ataku. Za potrebe hitne službe najbitnije je razlikovanje samoograničavajućih uzroka vrtoglavice poput vestibularnog neuritisa i benignog paroksizmalnog pozicijskog vertiga od opasnih uzroka poput moždanog udara. Unatoč razvoju i dostupnosti neuroradioloških pretraga, ispravna dijagnoza vrtoglavice prvenstveno se temelji na anamnestičkim podatcima i pregledu bolesnika, što će biti prikazano u ovom tekstu.