bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of photodegradation on the removal of color and phenolic compounds from palm oil mill effluent by Arthrospira platensis
Authors: Nur M. M. Azimatun , Garcia G. M. , Boelen P. , Buma Anita G. J.
Published: December 2020

Palm oil mill effluent (POME) released from conventional treatment systems poses severe environmental problems due to its dark color, its high chemical oxygen demand (COD), and high content of phenolic compounds. However, the possible biodegradation of phenolic compounds and color by microalgae was not well explored. This research aimed to reveal optimal conditions for pollutant removal through biodegradation by the cyanobacterium Arthrospira platensis. This species was grown under a range of POME fractions and environmental conditions (irradiance, salinity, nutrients) during which growth, final biomass, color, COD, and phenolic compound levels were followed. POME fractions influenced A. platensis growth rate, final biomass, COD, and color removal. The optimization of phenolic compound removal by using central composite design (CCD) response surface methodology (RSM) showed that low light and high initial phenolic compounds promoted the activity of A. platensis to degrade phenolic compounds. The combination of high initial phenolic compounds and high light intensity increased the growth rate up to 0.45 days−1 and final biomass up to 400 mg L−1, while total phenolic compounds were almost completely (94%) removed. Finally, this study showed that phenolic compounds and color degradation from POME were dominated by the activity of photodegradation at high irradiance, while the activity of A. platensis dominated at low light intensity.
Identification of suitable Botryococcus braunii strains for non-destructive in situ hydrocarbon extraction
Authors: Kleinert Christian , Griehl Carola
Published: December 2020

The process of milking microalgae is a promising approach to reduce the downstream costs for the production of valuable substances from microalgae by avoiding the steps of harvest, dewatering, and cell disruption of the common process chain (cultivation, harvesting, dewatering, cell disruption, extraction, purification). The green microalga Botryococcus braunii is particularly suited for this process due to its ability to produce large amounts of long-chain hydrocarbons accumulating in an extracellular matrix. The extracellular location of hydrocarbons is an enormous advantage in comparison with other microalgae that accumulate lipids in intracellular lipid bodies. At present, only a few B. braunii strains (UTEX 572, CCAP 807/2, SAG 807/1, FACHB 357, Bot22, and SCCAP 1761) have been examined for the process of long-term repetitive milking. In order to identify promising candidates for the milking process, twelve different B. braunii strains (SAG 30.81, SAG 807/1, UTEX 572, UTEX 2441, CCAP 807/2, ACOI 58, ACOI 1257, SCCAP K-1489, var. Showa, Bot22, SCCAP K-1761, and CCALA 779) were investigated in terms of growth, lipid accumulation, nutrient uptake, solvent compatibility, and extracellular hydrocarbon extractability. Based on these results, a ranking was defined in view of eligibility for non-destructive hydrocarbon extraction. Results indicate a particular potential for hydrocarbon milking for two of those twelve B. braunii strains. The strain Showa (71 out of 75 ranking points), which has not yet been examined for long-term repetitive milking, and the strain Bot22 (64 out of 75 ranking points) seem to be the most suitable strains for the milking process. They both possess good extractant compatibility including hydrocarbon extractability as well as high biomass and lipid productivity.
Microdistribution of Magnetic Resonance Imaging Contrast Agents in Atherosclerotic Plaques Determined by LA-ICP-MS and SR-μXRF Imaging
Authors: Uca Yavuz Oguz , Hallmann David , Hesse Bernhard , Seim Christian , Stolzenburg Nicola , Pietsch Hubertus , Schnorr Jörg , Taupitz Matthias
Published: December 2020

Purpose

Contrast-enhanced magnetic resonance imaging (MRI) has the potential to replace angiographic evaluation of atherosclerosis. While studies have investigated contrast agent (CA) uptake in atherosclerotic plaques, exact CA spatial distribution on a microscale is elusive. The purpose of this study was to investigate the microdistribution of gadolinium (Gd)- and iron (Fe) oxide-based CA in atherosclerotic plaques of New Zealand White rabbits.

Procedures

The study was performed as a post hoc analysis of archived tissue specimens obtained in a previous in vivo MRI study conducted to investigate signal changes induced by very small superparamagnetic iron oxide nanoparticles (VSOP) and Gd-BOPTA. For analytical discrimination from endogenous Fe, VSOP were doped with europium (Eu) resulting in Eu-VSOP. Formalin-fixed arterial specimens were cut into 5-μm serial sections and analyzed by immunohistochemistry (IHC: Movat’s pentachrome, von Kossa, and Alcian blue (pH 1.0) staining, anti-smooth muscle cell actin (anti-SMA), and anti-rabbit macrophage (anti-RAM-11) immunostaining) and elemental microscopy with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and synchrotron radiation μX-ray fluorescence (SR-μXRF) spectroscopy. Elemental distribution maps of Fe, Eu, Gd, sulfur (S), phosphorus (P), and calcium (Ca) were investigated.

Results

IHC characterized atherosclerotic plaque pathomorphology. Elemental microscopy showed S distribution to match the anatomy of arterial vessel wall layers, while P distribution corresponded well with cellular areas. LA-ICP-MS revealed Gd and Fe with a limit of detection of ~ 0.1 nmol/g and ~ 100 nmol/g, respectively. Eu-positive signal identified VSOP presence in the vessel wall and allowed the comparison of Eu-VSOP and endogenous Fe distribution in tissue sections. Extracellular matrix material correlated with Eu signal intensity, Fe concentration, and maximum Gd concentration. Eu-VSOP were confined to endothelium in early lesions but accumulated in cellular areas in advanced plaques. Gd distribution was homogeneous in healthy arteries but inhomogeneous in early and advanced plaques. SR-μXRF scans at 0.5 μm resolution revealed Gd hotspots with increased P and Ca concentrations at the intimomedial interface, and a size distribution ranging from a few micrometers to submicrometers.

Conclusions

Eu-VSOP and Gd have distinct spatial distributions in atherosclerotic plaques. While Eu-VSOP distribution is more cell-associated and might be used to monitor atherosclerotic plaque progression, Gd distribution indicates arterial calcification and might help in characterizing plaque vulnerability.
Do Trainee Mindfulness Teachers Practice What They Teach? Motivation, Challenges, and Learning Gaps
Authors: Bowden Allison , Norton Katie , Griffith Gemma Maria
Published: December 2020

Objectives

Research concerned with mindfulness-based program (MBP) teacher training has focused on the importance of developing teacher competency and integrity, with little emphasis on the experience of trainees themselves. The aim of this study was to investigate the experiences of trainee MBPs teachers as they delivered their first MBPs, with a focus on how they utilized their personal mindfulness practice to support themselves during this time.

Methods

We explored the experiences of university-based trainee teachers of Mindfulness-Based Stress Reduction (MBSR) when starting to teach, the ways they negotiated any challenges, and the extent to which they felt supported by their mindfulness practice. Semi-structured interviews were conducted with new MBSR teachers currently on a training course (N = 8). The interview data were analyzed using inductive thematic analysis.

Results

The key findings of the study were that trainee teachers were deeply motivated to teach MBPs with great integrity; did not anticipate the amount of time and effort needed to deliver their first MBSR courses; had concerns about the viability of the 8-week format of MBSR; needed more development in the area of self-reflection; and do indeed practice what they teach, and used their personal mindfulness practice to work with challenges.

Conclusions

These findings show that trainee mindfulness teachers are actively engaged with developing their teaching skills, and offer directions for how the pedagogy of MBP teacher training may be further developed. Trainees might benefit from additional pedagogical input on the practicalities of delivering MBSR in community settings, and on the development of reflective skills.
A Rights-Holder View on Human Rights Provisions in Olympic Bidding and Hosting Regulations
Authors: Heerdt Daniela
Published: December 2020

The Paris 2024 Summer Olympics will be the first Olympic Games for which human rights provisions were added to the Host City Contract (HCC). The Milano/Cortina 2026 Winter Olympics will be the first edition of the Games that were awarded with human rights requirements forming part of the candidature process. The inclusion of human rights provisions into hosting and bidding regulations can be seen as a reaction of the International Olympic Committee (IOC) to the increasing pressure from civil society to address adverse human rights impacts of these events. This essay provides an analysis of the benefits and shortcomings of this development and reveals that from a rights-holder perspective, the benefits are meaningless. More specifically, it argues that potential benefits are cancelled out by the shortcomings and most importantly that there is a mismatch between intended and actual beneficiaries of these provisions.
Statehood and the Olympic Games
Authors: Gauthier Ryan
Published: December 2020

Sport is a useful area of study to test assumptions of international law. International law has traditionally focused on states and on international organizations that oversee specialized areas of human activity. International sport is overseen by an NGO—the International Olympic Committee (IOC). Yet sport is of great interest to states, serving as a testing ground of national superiority by providing a simple narrative of “winners” and “losers” in competition. Meanwhile, entities that are not yet states have historically been able to participate in international sport more readily than in other areas of international relations. This essay will examine the connection between participation in the Olympic Games and claims to statehood. In doing so, this essay will outline the modern approach to statehood, consider sport's role in that approach, and examine two case studies: the German Democratic Republic, and Kosovo.
Core handling, transportation and processing for the South Pole ice core (SPICEcore) project
Authors: Souney Joseph M. , Twickler Mark S. , Aydin Murat , Steig Eric J. , Fudge T. J. , Street Leah V. , Nicewonger Melinda R. , Kahle Emma C. , Johnson Jay A. , Kuhl Tanner W. , Casey Kimberly A. , Fegyveresi John M. , Nunn Richard M. , Hargreaves Geoffrey M.
Published: December 2020

An intermediate-depth (1751 m) ice core was drilled at the South Pole between 2014 and 2016 using the newly designed US Intermediate Depth Drill. The South Pole ice core is the highest-resolution interior East Antarctic ice core record that extends into the glacial period. The methods used at the South Pole to handle and log the drilled ice, the procedures used to safely retrograde the ice back to the National Science Foundation Ice Core Facility (NSF-ICF), and the methods used to process and sample the ice at the NSF-ICF are described. The South Pole ice core exhibited minimal brittle ice, which was likely due to site characteristics and, to a lesser extent, to drill technology and core handling procedures.
Understanding the Problem of “Hype”: Exaggeration, Values, and Trust in Science
Authors: Intemann Kristen
Published: December 2020

Several science studies scholars report instances of scientific “hype,” or sensationalized exaggeration, in journal articles, institutional press releases, and science journalism in a variety of fields (e.g., Caulfield and Condit 2012). Yet, how “hype” is being conceived varies. I will argue that hype is best understood as a particular kind of exaggeration, one that explicitly or implicitly exaggerates various positive aspects of science in ways that undermine the goals of science communication in a particular context. This account also makes clear the ways that value judgments play a role in judgments of “hype,” which has implications for detecting and addressing this problem.
Leveraging community engagement capacity to address COVID-19 disparities among Pacific Islander and Latinx Communities in Arkansas
Authors: McElfish Pearl A. , Cleek Anna B. , Willis Don E. , Purvis Rachel S. , James Laura P.
Published: December 2020

Northwest Arkansas, particularly Benton and Washington counties, is one of the highest COVID-19 hot spots in the United States (US), with more than half of all reported cases in this area identifying as Latinx or Pacific Islander, even though these communities account for less than 20% of the overall population. The University of Arkansas for Medical Sciences (UAMS) leveraged their existing relationship with 18 key community partners. Partners collaboratively developed a COVID-19 Response Strategy to ensure coordinated effort for Latinx and Pacific Islander communities with four interrelated strategies: health education, testing, contact tracing, and supported quarantine/case management.
Perspectives of scientists on disseminating research findings to non-research audiences
Authors: McNeal Demetria M. , Glasgow Russell E. , Brownson Ross C. , Matlock Daniel D. , Peterson Pamela N. , Daugherty Stacie L. , Knoepke Christopher E.
Published: December 2020

Background:

Little is known about practices used to disseminate findings to non-research, practitioner audiences. This study describes the perspectives, experience and activities of dissemination & implementation (D&I) scientists around disseminating their research findings.

Methods:

The study explored D&I scientists’ experiences and recommendations for assessment of dissemination activities to non-research audiences. Existing list serves were used to recruit scientists. Respondents were asked three open-ended questions on an Internet survey about dissemination activities, recommendations for changing evaluation systems and suggestions to improve their own dissemination of their work.

Results:

Surveys were completed by 159 scientists reporting some training, funding and/or publication history in D&I. Three themes emerged across each of the three open-ended questions. Question 1 on evaluation generated the themes of: 1a) promotional review; 1b) funding requirements and 1c) lack of acknowledgement of dissemination activities. Question 2 on recommended changes generated the themes of: 2a) dissemination as a requirement of the academic promotion process; 2b) requirement of dissemination plan and 2c) dissemination metrics. Question 3 on personal changes to improve dissemination generated the themes of: 3a) allocation of resources for dissemination activities; 3b) emerging dissemination channels and 3c) identify and address issues of priority for stakeholders.

Conclusions:

Our findings revealed different types of issues D&I scientists encounter when disseminating findings to clinical, public health or policy audiences and their suggestions to improve the process. Future research should consider key requirements which determine academic promotion and grant funding as an opportunity to expand dissemination efforts.
Conflicts and Continuity in the Eleventh-Century Religious Reform: The Traditions of San Miniato al Monte in Florence and the Origins of the Benedictine Vallombrosan Order
Authors: SALVESTRINI FRANCESCO
Published: December 2020

Studies of the ecclesiastical reform of the eleventh century have often highlighted conflict between reforming monks and simoniac clerics. This was especially true in the urban contexts of Milan and Florence, cities that played a leading role, at the time, in the history of Italian religious life. Through the presentation of an exemplary case study, this paper shows how around an important Florentine monastery, an episcopal foundation, the conflict between ‘conservatives’ and reformers did not obliterate the genesis and permanence of long-term devotional and cultural traditions. Although these traditions emerged in a context of conflict, they were able to overcome it and develop into a new and enduring form of religiosity that lasted from the Romanesque period to the Early Renaissance.
Gender, Credit, and Firm Outcomes
Authors: Delis Manthos D. , Hasan Iftekhar , Iosifidi Maria , Ongena Steven
Published: December 2020

Small and micro-enterprises are usually majority-owned by entrepreneurs. Using a unique sample of loan applications from such firms, we study the role of owners’ gender in bank credit decisions and post-credit-decision firm outcomes. We find that, ceteris paribus, female entrepreneurs are more prudent loan applicants than are males because they are less likely to apply for credit or to default after loan origination. The relatively more aggressive behavior of male applicants pays off, however, in terms of higher average firm performance after loan origination.
Jainism in Danger? Temple entry and the rhetoric of religion and reform in post-colonial India
Authors: SETHI MANISHA
Published: December 2020

A bitter debate broke out in the Digambar Jain community in the middle of the twentieth century following the passage of the Bombay Harijan Temple Entry Act in 1947, which continued until well after the promulgation of the Untouchability (Offences) Act 1955. These laws included Jains in the definition of ‘Hindu’, and thus threw open the doors of Jain temples to formerly Untouchable castes. In the eyes of its Jain opponents, this was a frontal and terrible assault on the integrity and sanctity of the Jain dharma. Those who called themselves reformists, on the other hand, insisted on the closeness between Jainism and Hinduism. Temple entry laws and the public debates over caste became occasions for the Jains not only to examine their distance—or closeness—to Hinduism, but also the relationship between their community and the state, which came to be imagined as predominantly Hindu. This article, by focusing on the Jains and this forgotten episode, hopes to illuminate the civilizational categories underlying state practices and the fraught relationship between nationalism and minorities.
The mental health impact of COVID-19 and lockdown-related stressors among adults in the UK
Authors: Chandola Tarani , Kumari Meena , Booker Cara L. , Benzeval Michaela
Published: December 2020

Background

The COVID-19 pandemic in the UK and subsequent lockdown may have affected the mental health of the population. This study examines whether there was an increase in the prevalence and incidence of common mental disorders (CMD) in the UK adult population during the first months of lockdown and whether changes in CMD were associated with stressors related to the pandemic and lockdown.

Methods

Longitudinal data from the UK Household Longitudinal Study waves 10–11: 2019–2020 and waves 1–4 of the COVID-19 monthly surveys in April (n = 17 761) to July 2020 (n = 13 754), a representative sample of UK adult population, were analysed. CMD was measured using the 12-item General Health Questionnaire (GHQ-12) (cut-off >2). Changes in CMD were analysed in relation to COVID-19 and social stressors.

Results

Around 29% of adults without CMD less than a year earlier had a CMD in April 2020. However, by July 2020, monthly incidence of CMD had reduced to 9%. Most employment, financial and psychological ‘shocks’ were at their highest levels in April and reduced steadily in later months. Despite the lifting of some lockdown conditions by July, stressors related to loneliness, unemployment, financial problems and domestic work continued to influence CMD.

Conclusion

Some COVID-19 policy responses such as furloughing may have been effective in mitigating the increase in CMD for some groups of employees. Despite some reduction in levels of pandemic and lockdown-related stressors by the middle of 2020, loneliness and financial stressors remained key determinants of incidence in CMD among the UK adult population.
The role of dietary nitrate and the oral microbiome on blood pressure and vascular tone
Authors: Alzahrani H. S. , Jackson K. G. , Hobbs D. A. , Lovegrove J. A.
Published: December 2020

There is increasing evidence for the health benefits of dietary nitrates including lowering blood pressure and enhancing cardiovascular health. Although commensal oral bacteria play an important role in converting dietary nitrate to nitrite, very little is known about the potential role of these bacteria in blood pressure regulation and maintenance of vascular tone. The main purpose of this review is to present the current evidence on the involvement of the oral microbiome in mediating the beneficial effects of dietary nitrate on vascular function and to identify sources of inter-individual differences in bacterial composition. A systematic approach was used to identify the relevant articles published on PubMed and Web of Science in English from January 1950 until September 2019 examining the effects of dietary nitrate on oral microbiome composition and association with blood pressure and vascular tone. To date, only a limited number of studies have been conducted, with nine in human subjects and three in animals focusing mainly on blood pressure. In general, elimination of oral bacteria with use of a chlorhexidine-based antiseptic mouthwash reduced the conversion of nitrate to nitrite and was accompanied in some studies by an increase in blood pressure in normotensive subjects. In conclusion, our findings suggest that oral bacteria may play an important role in mediating the beneficial effects of nitrate-rich foods on blood pressure. Further human intervention studies assessing the potential effects of dietary nitrate on oral bacteria composition and relationship to real-time measures of vascular function are needed, particularly in individuals with hypertension and those at risk of developing CVD.
Transient marginal identities and networks in early modern Madrid: the 1614 case of the ‘Armenian’, ‘Greek’ and ‘Turkish’ counterfeiters
Authors: Mierau Konstantin
Published: December 2020

This article centres on a trial held in Madrid in 1614 involving a group identified as ‘vagrants’ of ‘Armenian’ and ‘Greek’ background. In order to tease out the ways in which the presence of foreigners challenged the institutions and citizens, this article approaches these defendants as relationally defined actors in the urban dynamic. It reveals the tactics marginal groups employed vis-à-vis strategic attempts by the municipal government to control foreigners by assigning them identities based on ethnicity. This case-study thus calls into question notions of vagrancy and identification based on ethnicity (‘Armenian’ and ‘Greek’, in particular) in Madrid under Phillip III and IV. In doing so, it shows marginality to be a key yet elusive site for cultural encounters and collaboration in early modern Europe, in which multilingual and culturally fluid social actors related to the Armenian diaspora played a central role.
Impact of bovine respiratory disease in U.S. beef cattle
Authors: White Brad J. , Larson Bob L.
Published: December 2020

Bovine respiratory disease (BRD) is one of the most common and costly diseases of beef cattle. Much research has been conducted to understand prevention, treatment, and economic impacts of this syndrome. Impacts from BRD occur in multiple phases of the beef industry including both pre- and post-weaned calves. This disease causes negative impacts due to production losses, treatment costs, and cattle mortality. The large scope of BRD impacts merits further research on effective prevention and intervention technologies to limit deleterious impacts to the cattle industry.
Claiming the right to rule: regime legitimation strategies from 1900 to 2019
Authors: Tannenberg Marcus , Bernhard Michael , Gerschewski Johannes , Lührmann Anna , von Soest Christian
Published: December 2020

Governments routinely justify why the regime over which they preside is entitled to rule. These claims to legitimacy are both an expression of and shape of how a rule is being exercised. In this paper, we introduce new expert-coded measures of regime legitimation strategies (RLS) for 183 countries in the world from 1900 to 2019. Country experts rated the extent to which governments justify their rule based onperformance, the person of the leader, rational-legal procedures, and ideology. They were also asked to qualify the ideology of the regime. The main purposes of this paper are to present the conceptual basis for the measure, describe the data, and provide convergent, content, and construct validity tests for new measures. Our measure of regime legitimation performs well in all these three validation tests, most notably, the construct validity exercise which explores commonly held beliefs about leadership under populist rule.
A rationale for the legitimacy of the world legal order: Kant’s idea of a cosmopolitan will
Authors: CORRADETTI CLAUDIO
Published: December 2020

In this contribution I provide an interpretation of Stone Sweet’s and Ryan’s cosmopolitan legal order in conjunction with a certain reconstruction of the Kantian cosmopolitan rationale. Accordingly, I draw attention to the connection between the notion of a general (cosmopolitan) will in Kant’s reinterpretation of Rousseau and the role of the European Court of Human Rights (ECtHR) as an ‘interpreter’ of such will. I conclude by suggesting that the opportunity of extending the CLO also accounts for a variety of other poliarchical regimes that, taken as a whole, illustrate the landscapes of contemporary global constitutionalism.
Dialogic constitutionalism and judicial review
Authors: BENHABIB SEYLA
Published: December 2020

In A Cosmopolitan Legal Order: Kant, Constitutional Justice and the European Convention on Human Rights, Alec Stone Sweet and Clare Ryan reconstruct Kant’s legal philosophy as a program of cosmopolitan legal order (CLO). A CLO is defined as a multi-level, judicialized, transnational system of rights protection that confers on all persons, by virtue of their humanity, the entitlement to challenge the rights-regarding decisions of public officials, who are under an obligation to assure the equal juridical status of all. The authors illustrate this claim with respect to the development of the ECtHR and the Court of Justice of the European Union. While generally agreeing with their argument, I claim that they minimize the republican aspects of Kant’s political philosophy in favour of strong judicial review. After outlining republican and democratic objections, I claim that their book illustrates a model that I call ‘dialogic constitutionalism’. Dialogic constitutionalism does not neglect legislative authority, but places it in a conversation with judicial authority, whether domestic or transnational; such conversations can serve to upgrade standards of rights protection over time and are not frozen precommitments. Constitutions also have a representative function of standing for the intergenerational continuity of the people, whereas legislatures are bound by electoral cycles.
Legal cosmopolitanism in international law
Authors: BJORGE EIRIK
Published: December 2020

This article concerns two aspects of Stone Sweet and Ryan’s theory of legal cosmopolitanism: (1) what the Kantian cosmopolitan legal order means for an international court; and (2) what it means for the holders of the rights that flow from the cosmopolitan legal order. The article interrogates the extent to which, in order to be considered a truly cosmopolitan legal order, the European Convention on Human Rights needs at times not only to make non-citizens free of rights equal to those of citizens, but also to give them stronger rights than those enjoyed by citizens. The article concludes by turning to the meaning of the European Convention beyond its European context. The European system for the protection of human rights and fundamental freedoms may fail or succeed, yet the enthusiasm that the most successful rights-protecting body in the world has created in bystanders, and the very fact that it came into being at all, prove that real progress is possible. From a Kantian perspective, this may well be its greatest accomplishment.
Seasonal Carbon Dynamics in the Near‐Global Ocean
Authors: Keppler L. , Landschützer P. , Gruber N. , Lauvset S. K. , Stemmler I.
Published: December 2020

The seasonal cycle represents one of the largest signals of dissolved inorganic carbon (DIC) in the ocean, yet these seasonal variations are not well established at a global scale. Here, we present the Mapped Observation‐Based Oceanic DIC (MOBO‐DIC) product, a monthly DIC climatology developed based on the DIC measurements from GLODAPv2.2019 and a two‐step neural network method to interpolate and map the measurements. MOBO‐DIC extends from the surface down to 2,000 m and from 65°N to 65°S. We find the largest seasonal amplitudes of surface DIC in the northern high‐latitude Pacific (∼30 to >50 μmol kg−1). Surface DIC maxima occur in hemispheric spring and minima in fall, driven by the input of DIC into the upper ocean by mixing during winter, and net community production (NCP) driven drawdown of DIC over summer. The seasonal pattern seen at the surface extends to a nodal depth of <50 m in the tropics and several hundred meters in the subtropics. Below the nodal depth, the seasonal cycle of DIC has the opposite phase, primarily owing to the seasonal accumulation of DIC stemming from the remineralization of sinking organic matter. The well‐captured seasonal drawdown of DIC in the mid‐latitudes (23° to 65°) allows us to estimate the spring‐to‐fall NCP in this region. We find a spatially relatively uniform spring‐to‐fall NCP of 1.9 ± 1.3 mol C m−2 yr−1, which sums to 3.9 ± 2.7 Pg C yr−1 over this region. This corresponds to a global spring‐to‐fall NCP of 8.2 ± 5.6 Pg C yr−1.
Resource Colimitation Drives Competition Between Phytoplankton and Bacteria in the Southern Ocean
Authors: Ratnarajah Lavenia , Blain Stéphane , Boyd Philip W. , Fourquez Marion , Obernosterer Ingrid , Tagliabue Alessandro
Published: December 2020

Across the Southern Ocean, phytoplankton growth is governed by iron and light, while bacterial growth is regulated by iron and labile dissolved organic carbon (LDOC). We use a mechanistic model to examine how competition for iron between phytoplankton and bacteria responds to changes in iron, light, and LDOC. Consistent with experimental evidence, increasing iron and light encourages phytoplankton dominance, while increasing LDOC and decreasing light favors bacterial dominance. Under elevated LDOC, bacteria can outcompete phytoplankton for iron, most easily under lower iron. Simulations reveal that bacteria are major iron consumers and suggest that luxury storage plays a key role in competitive iron uptake. Under seasonal conditions typical of the Southern Ocean, sources of LDOC besides phytoplankton exudation modulate the strength of competitive interactions. Continued investigations on the competitive fitness of bacteria in driving changes in primary production in iron‐limited systems will be invaluable in refining these results.
Roles of Shear and Convection in Driving Mixing in the Ocean
Authors: Ivey Gregory N. , Bluteau Cynthia E. , Gayen Bishakhdatta , Jones Nicole L. , Sohail Taimoor
Published: December 2020

Using field, numerical, and laboratory studies, we consider the roles of both shear and convection in driving mixing in the interior of the density‐stratified ocean. Shear mixing dominates when the Richardson number Ri < 0.25, convective mixing dominates when Ri > 1.0, and in the intermediate regime when 0.25 < Ri < 1.0 both shear and convection can contribute to mixing. For pure shear mixing the mixing efficiency Rif approaches 0.5, while for pure convective mixing the mixing efficiency Rif approaches 0.75. The diapycnal diffusivities for the two mechanisms are given by very different expressions. Despite these complexities, a simple mixing length model using the mean flow shear S provides robust estimates of diffusivity across the range 0 < Ri < 2. To account for the roles of both shear and convection over this range of Ri, we also formulate a modified version of the empirical KPP model for parameterizing ocean mixing in numerical models.
The Role of the Mean State on MJO Simulation in CESM2 Ensemble Simulation
Authors: Kang Daehyun , Kim Daehyun , Ahn Min‐Seop , Neale Richard , Lee Jiwoo , Gleckler Peter J.
Published: December 2020

This study examines the role of the mean state in the propagation of the Madden‐Julian oscillation (MJO) over the Maritime Continent (MC). We use an ensemble of simulations made with a single model—the Community Earth System Model version 2—to assess the effect of the mean state that is unaffected by that of model components such as parameterization schemes. Results show that the background meridional moisture gradient is much steeper over the MC region in the periods with a stronger MJO propagation. Column water vapor budget of the MJO strongly suggests that the simulated mean state affects MJO via its impacts on moisture dynamics—a greater advection of mean moisture by MJO wind in the MC region is responsible for the anomalous MJO activity.
A New Reconstruction for Permian East Gondwana Based on Zircon Data From Ophiolite of the East Australian Great Serpentinite Belt
Authors: Milan L. A. , Belousova E. A. , Glen R. A. , Chapman T. , Kalmbach J. , Fu B. , Ashley P. M.
Published: December 2020

The Great Serpentinite Belt of eastern Australia is a ∼1500 km long dismembered ophiolite assumed to be Cambrian based on studies of small (typically <50 m2) exotic meta‐igneous inclusions despite contrasting ages (Cambrian—Devonian) and complex P‐T histories. To overcome these issues, we studied a ∼18 km2 coherent block of dismembered ophiolite that provides robust geological context to sampling the ophiolite. Zircon U‐Pb‐Hf‐O isotope and trace analyses from three plagiogranite dykes cutting massive gabbro confirm ∼283–277 Ma ages and a mantle source. As a result, we argue older Cambrian to Devonian plagiogranite and subducted blocks were inherited from previous subduction events in eastern Australia. These findings allow us to match the Great Serpentinite Belt with the contemporary Dun Mountain ophiolite (New Zealand) and the Koh ophiolite (New Caledonia), thus supporting a new, integrated Pacific Gondwana margin paleogeography involving multiple arcs and subduction zones.
On the Estimation of In‐Cloud Vertical Air Motion Using Radar Doppler Spectra
Authors: Zhu Zeen , Kollias Pavlos , Yang Fan , Luke Edward
Published: December 2020

Measurements of in‐cloud vertical air motion are key to quantitatively describe cloud dynamics and their role in cloud microphysics. Here, a retrieval technique for estimating the in‐cloud vertical air motion using the upward edge of the radar Doppler spectrum is presented. An additional broadening correction factor that depends on the signal‐to‐noise ratio (SNR) is introduced. A variety of independent measurements are used to assess the performance of the new technique. The vertical air motion is unbiased with an uncertainty of 0.2 m s−1 for SNR <30. The properties of in‐cloud vertical air motion are investigated from 1 year of ground‐based observations of warm marine boundary layer clouds. Clouds with higher LWP are characterized by stronger vertical air motions compared to those having lower LWP values.
A New Approach to Constrain the Seismic Origin for Prehistoric Turbidites as Applied to the Dead Sea Basin
Authors: Lu Yin , Moernaut Jasper , Bookman Revital , Waldmann Nicolas , Wetzler Nadav , Agnon Amotz , Marco Shmuel , Alsop G. Ian , Strasser Michael , Hubert‐Ferrari Aurélia
Published: December 2020

The seismic origin of turbidites is verified either by correlating such layers to historic earthquakes, or by demonstrating their synchronous deposition in widely spaced, isolated depocenters. A historic correlation could thus constrain the seismic intensity required for triggering turbidites. However, historic calibration is not applicable to prehistoric turbidites. In addition, the synchronous deposition of turbidites is difficult to test if only one deep core is drilled in a depocenter. Here, we propose a new approach that involves analyzing the underlying in situ deformations of prehistoric turbidites, as recorded in a 457 m‐long core from the Dead Sea center, to establish their seismic origin. These in situ deformations have been verified as seismites and could thus authenticate the trigger for each overlying turbidite. Moreover, our high‐resolution chemical and sedimentological data validate a previous hypothesis that soft‐sediment deformation in the Dead Sea formed at the sediment‐water interface.
Meltwater‐Driven Water‐Level Fluctuations of Bosten Lake in Arid China Over the Past 2,000 Years
Authors: Li Yuan , Hu Ling , Zhao Yongtao , Wang Haipeng , Huang Xiaozhong , Chen Guangjie , Leppänen Jaakko Johannes , Fontana Luciane , Ren Lele , Shi Zhilin , Liu Bing , Zhao Hui
Published: December 2020

Changes in water storage of the large freshwater lakes in Arid Central Asia (ACA) have significant implications for the regional social and ecological systems. Here we present a lake‐level record of the past 2,000 years from Bosten Lake, a large freshwater body in the region, using the sedimentary Cladoceran microfossil. The results suggest that a lower lake level and a higher salinity occurred during the cold, high‐precipitation periods of 280–450 AD and 1570–1850 AD, and that a higher lake level and a lower salinity occurred during the warm, low‐precipitation period of 450–1570 AD. The findings show that on the centennial timescale, the water‐level fluctuations of Bosten Lake were modulated mainly by temperature‐driven meltwater input. In addition, the shortage of freshwater during the cold period may have contributed to the collapse of the ancient cities and the depression of the trade along the Silk Road.
Foliage Senescence as a Key Parameter for Modeling Gross Primary Productivity in a Mediterranean Shrubland
Authors: Cueva Alejandro , Bullock Stephen H. , Méndez‐Alonzo Rodrigo , López‐Reyes Eulogio , Vargas Rodrigo
Published: December 2020

Although drylands cover >40% of the land surface, models of ecosystem gross primary productivity (GPP) generally have been designed for mesic temperate ecosystems. Arguably, GPP models often lack a good representation of vegetation phenology, particularly not estimating the ecosystem effects of the prolonged foliage senescence which may be common in drylands. To estimate daily GPP for a water‐limited Mediterranean shrubland, we propose a simple framework (GPPmod) using light use efficiency, a spectral vegetation index derived from digital cameras, and five meteorological variables, including an index of functional senescence of foliage (i.e., heat degree‐days). We tested the model with different combinations of meteorological variables but without senescence, using 1 year's data. The best formulation showed good agreement with GPP derived from eddy covariance (GPPEC; r2 = 0.53, RMSE = 0.77). However, including the foliage senescence parameter significantly improved model performance (r2 = 0.74, RMSE = 0.49), especially during the fall season. In the following year, we validated the parameters: The overall GPPmod and GPPEC comparison yielded an r2 = 0.78. We postulate that models that mainly rely on meteorological variables or greenness indices could yield an overestimation of annual GPP between 24% and 90%, while models including the foliage senescence parameter reduced that bias by 10% to 34%. Our results highlight the importance of incorporating the phenology of foliage senescence in models regarding productivity in drylands or dry sclerophyll ecosystems.
Late Pleistocene to Recent Deformation in the Thick‐Skinned Fold‐and‐Thrust Belt of Northwestern Argentina (Central Calchaquí Valley, 26°S)
Authors: Figueroa Sara , Weiss Jonathan R. , Hongn Fernando , Pingel Heiko , Escalante Leonardo , Elías Leonardo , Aranda‐Viana R. Germán , Strecker Manfred R.
Published: December 2020

The thick‐skinned fold‐and‐thrust belt on the eastern flank of the Andean Plateau in northwestern Argentina (NWA) is a zone of active contractional deformation characterized by fault‐bounded mountain ranges with no systematic spatiotemporal pattern of tectonic activity. In contrast, the thin‐skinned Subandean fold‐and‐thrust belt of northern Argentina and southern Bolivia is characterized primarily by in‐sequence (i.e., west to east) fault progression, with a narrow zone of Quaternary deformation focused at the front of the orogenic wedge. To better understand how recent deformation is accommodated across these mountain ranges and the Argentinian portion of the orogen in particular, estimating and comparing deformation rates and patterns across different timescales is essential. We present Late Pleistocene shortening rates for the central Calchaquí intermontane valley in NWA associated with at least three episodes of deformation. Global Positioning System data for the same region reveal a gradual decrease in horizontal surface velocities from the Eastern Cordillera toward the foreland, which contrasts with the rapid velocity gradient associated with a locked décollement in the Subandean Ranges of southern Bolivia. Our new results represent a small view of regional deformation that, when considered in combination with the shallow crustal seismicity and decadal‐scale surface velocities, support the notion that strain release in NWA is associated with numerous slowly deforming structures that are distributed throughout the orogen.
Associations between left ventricular structure and function with cardiorespiratory fitness and body composition in individuals with cervical and upper thoracic spinal cord injury
Authors: Alrashidi Abdullah A. , Balthazaar Shane J. T. , Currie Katharine D. , Nightingale Tom E. , Krassioukov Andrei V.
Published: December 2020

Study design

Cross-sectional.

Objective

It is known that left ventricular mass (LVM) and cardiorespiratory fitness (CRF) are associated to fat-free mass (FFM).  It is unknown if these factors associated with left ventricular (LV) structure and function outcomes in individuals with spinal cord injury (SCI).

Setting

University-based laboratory.Vancouver, BC, Canada.

Methods

Thirty-two individuals (aged 40 ± 11 years) with chronic, motor-complete SCI between the fourth cervical and sixth thoracic levels were recruited. Echocardiographic LV parameters and body composition were assessed at rest, as per the recommended guidelines for each technique. CRF was assessed during an incremental arm-cycle exercise test until volitional fatigue. The appropriate bivariate correlation coefficients [i.e., Pearson’s (r) and Spearman’s rank (Rs)] tests were used for normal and non-normal distributed variables, respectively.

Results

LV structure and function parameters were not associated with the indexed peak oxygen consumption (V̇O2peak) [i.e., relative to body weight or FFM] (Rs values ranged from −0.168 to 0.134, all P values > 0.223). The association between peak oxygen pulse and the resting echocardiographic-obtained SV was medium sized (Rs = 0.331, P = 0.069). The LVM associations with FFM and fat mass (FM) were large and small (r = 0.614, P < 0.001 and r = 0.266, P = 0.141, respectively). Associations of absolute V̇O2peak were medium- positive with FFM (Rs = 0.414, P = 0.021) but negative with FM (Rs = −0.332, P = 0.068).

Conclusion

LV parameters measured at rest are not associated with V̇O2peak in individuals with cervical and upper-thoracic SCI. Given the observed associations between LVM and V̇O2peak with FFM, future studies may consider utilizing FFM for indexing cardiovascular measures following SCI.
COVID-19 vaccine race: watch your step for cancer patients
Authors: Fanciullino Raphaelle , Ciccolini Joseph , Milano Gerard
Published: December 2020

Patients with cancer should benefit from COVID-19 vaccination. Some of the most advanced vaccine candidates are mRNAs encapsulated into lipid carriers, and small liposomes are expected to accumulate in tumour tissues through the enhanced and permeation retention effect. However, to what extent solid tumours could take up a significant part of the vaccine dose as well remains unknown. This calls for a careful evaluation of the efficacy of these promising mRNA COVID-19 vaccines administered as lipid carriers for patients with solid tumours, including a possible re-appraisal of the dosing for optimal protection of this specific and frail population.
Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism
Authors: Huang Xiaozhong , Shi Yujuan , Chen Hongjin , Le Rongrong , Gong Xiaohua , Xu Ke , Zhu Qihan , Shen Feixia , Chen Zimiao , Gu Xuemei , Chen Xiaojun , Chen Xiong
Published: December 2020

Diabetic nephropathy (DN) as a global health concern is closely related to inflammation and oxidation. Isoliquiritigenin (ISL), a natural flavonoid compound, has been demonstrated to inhibit inflammation in macrophages. Herein, we investigated the effect of ISL in protecting against the injury in STZ-induced type 1 DN and in high glucose-induced NRK-52E cells. In this study, it was revealed that the administration of ISL not only ameliorated renal fibrosis and apoptosis, but also induced the deterioration of renal function in diabetic mice. Mediated by MAPKs and Nrf-2 signaling pathways, respectively, upstream inflammatory response and oxidative stress were neutralized by ISL in vitro and in vivo. Moreover, as further revealed by the results of molecular docking, sirtuin 1 (SIRT1) binds to ISL directly, and the involvement of SIRT1 in ISL-mediated renoprotective effects was confirmed by studies using in vitro models of SIRT1 overexpression and knockdown. In summary, by reducing inflammation and oxidative stress, ISL has a significant pharmacological effect on the deterioration of DN. The benefits of ISL are associated with the direct binding to SIRT1, the inhibition of MAPK activation, and the induction of Nrf-2 signaling, suggesting the potential of ISL for DN treatment.
Establishment of a morphological atlas of the Caenorhabditis elegans embryo using deep-learning-based 4D segmentation
Authors: Cao Jianfeng , Guan Guoye , Ho Vincy Wing Sze , Wong Ming-Kin , Chan Lu-Yan , Tang Chao , Zhao Zhongying , Yan Hong
Published: December 2020

The invariant development and transparent body of the nematode Caenorhabditis elegans enables complete delineation of cell lineages throughout development. Despite extensive studies of cell division, cell migration and cell fate differentiation, cell morphology during development has not yet been systematically characterized in any metazoan, including C. elegans. This knowledge gap substantially hampers many studies in both developmental and cell biology. Here we report an automatic pipeline, CShaper, which combines automated segmentation of fluorescently labeled membranes with automated cell lineage tracing. We apply this pipeline to quantify morphological parameters of densely packed cells in 17 developing C. elegans embryos. Consequently, we generate a time-lapse 3D atlas of cell morphology for the C. elegans embryo from the 4- to 350-cell stages, including cell shape, volume, surface area, migration, nucleus position and cell-cell contact with resolved cell identities. We anticipate that CShaper and the morphological atlas will stimulate and enhance further studies in the fields of developmental biology, cell biology and biomechanics.