bluuebunny/crossref_metadata_2025 huggingface dataset:
School Principals’ Stress Profiles During COVID-19, Demands, and Resources
Authors: Upadyaya Katja , Toyama Hiroyuki , Salmela-Aro Katariina
Published: December 2021

The present study examined latent profiles of school principals’ stress concerning students’, teachers’, parents’, and principals’ own ability to cope during the COVID-19 pandemic. In addition, the role of job demands (workload, remote work stress, difficulty to detach from work, COVID-19 crisis, COVID-19 infections at school, impact of COVID-19 on future teaching), resources (buoyancy, effective crisis leadership, social appreciation, successful transition to remote teaching), and occupational well-being (measured as job burnout and engagement) in predicting the latent profiles of stress sources was examined. The participants were 535 (59% women) school principals across Finland, who answered to a questionnaire concerning their sources of stress and occupational well-being during spring 2020. Three latent profiles were identified according to principals’ level of stress: high stress (41.4% of the school principals), altered stress (35.9%), and low stress (22.7%) profiles. Work burnout, workload, COVID-19 related concerns, and difficulty to detach from work increased the probability of principals belonging to the high or altered stress profile rather than to the low stress profile. Work engagement, buoyancy, and social appreciation increased the probability of principals belonging to the low rather than to the high or altered stress profile.
From Whence Cometh My Help? Psychological Distress and Help-Seeking in the Evangelical Christian Church
Authors: Lloyd Christopher E. M. , Reid Graham , Kotera Yasuhiro
Published: December 2021

Seeking professional help for psychological distress is generally associated with improved outcomes and lower levels of distress. Given the saliency of religious teachings, it has been shown that aspects of Christian belief may influence adherents’ attitudes towards mental health help-seeking. Based on existing research on American Evangelicals, it was hypothesised that religious social support would positively predict attitudes towards mental health help-seeking, whilst fundamentalism, mental distress, and the belief that psychopathology is caused by immoral or sinful living would negatively predict participants’ attitudes. On a convenience sample of 252 British Evangelicals, our hypotheses were supported and these variables significantly predicted participants’ attitudes towards seeking mental health help, F(7,243) = 9.64, p < 0.001, R2 = 0.195. These findings together suggest that whilst religious support positively predicts help-seeking attitudes, Evangelical fundamentalism, in addition to beliefs that mental illness has a spiritual cause, as well as experiences of mental distress may be associated with more negative attitudes towards psychotherapeutic intervention. Thus, mental health practitioners should be aware of clients’ religious worldviews and tailor interventions appropriately, acknowledging that working with religious organisations may yield the most positive outcomes for patients.
Psychological Distress Among Occupational Health Professionals During Coronavirus Disease 2019 Pandemic in Spain: Description and Effect of Work Engagement and Work Environment
Authors: Ruiz-Frutos Carlos , Ortega-Moreno Mónica , Soriano-Tarín Guillermo , Romero-Martín Macarena , Allande-Cussó Regina , Cabanillas-Moruno Juan Luis , Gómez-Salgado Juan
Published: December 2021

The impact of the coronavirus disease 2019 (COVID-19) pandemic on the mental health of hospital health professionals has been widely described, but few studies have focused on occupational health professionals. Therefore, the objective of this study was to assess psychological distress (PD) of occupational health workers and its relationship with their work engagement (WE) and work environment characteristics. A cross-sectional survey was conducted. A sample of 499 nurses and physicians participated in the study. Variables included demographic data, work environment characteristics, work engagement Utrecht Work Engagement Scale (UWES-9) and psychological distress General Health Questionnaire (GHQ-12). The Chi-square Automatic Interaction Detection method was performed for data analysis. Data collection took place via the internet between April 23 and June 24, 2020. A total of 65.53% of the participants had PD, and the total mean score of the UWES-9 scale was 34.80 (SD = 10.69). Workload, conflicts, stressful situations, and less job satisfaction were significantly related to a higher percentage of PD (p < 0.05). Participants with low engagement showed higher levels of PD (76.7%; p < 0.001). The dedication was revealed as the most significant dimension. Interventions aimed at promoting resilience and coping strategies are suggested. WE should be fostered as a preventive measure against PD among occupational health workers. By protecting workers, occupational health departments have a shared responsibility with public health in containing the pandemic. Therefore, it is essential to prevent the psychological impact that this responsibility may have on occupational health workers by implementing prevention measures.
What Is the Mechanism Underlying the Interleaving Effect in Category Induction: An Eye-Tracking and Behavioral Study
Authors: Ge Yabo , Li Fengying , Li Xinyu , Li Weijian
Published: December 2021

Interleaved practice (i.e., exemplars from different categories are intermixed within blocks) has been shown to enhance induction performance compared to blocked practice (i.e., exemplars from the same category are presented sequentially). The main aim of the present study was to examine explanations of why interleaved practice produces this benefit in category induction (known as the interleaving effect). We also evaluated two hypotheses, the attention attenuation hypothesis and the discriminative-contrast hypothesis, by collecting data on participants’ fixation on exemplars, provided by eye-tracking data, and manipulating the degree of discriminative-contrast. In Experiments 1 and 2, participants were instructed to learn the style of 12 new artists in blocked and interleaved practice in fixed-paced and self-paced learning conditions, respectively. We examined fixation durations for six positions (temporal sequence of exemplars presented in each block) using eye-tracking. The results of the two experiments, based on eye-tracking data, suggested that attention attenuation may not be the primary mechanism underlying the interleaving effect in category induction. In Experiment 3, we manipulated the degree of discriminative-contrast to examine the impact on the interleaving effect in category induction. The results showed that the main effect of the degree of discriminative-contrast was significant, and performance in the high-contrast condition was significantly better than those in the medium-contrast and low-contrast conditions. Thus, the current results support the discriminative-contrast hypothesis rather than the attention attenuation hypothesis.
How Labor Values Affect Mental Health: An Analysis From the Perspective of Social Support
Authors: Gu Yuliang , Chao Xiaomei
Published: December 2021

To explore the positive and negative effects of labor values on mental health from the aspects of life satisfaction and psychological distress, and further verify the mediating role of social support. A total of 2,691 primary and secondary school students were surveyed by Labor Values Scale, the Multidimensional Scale of Social Support, General Health Questionnaire and Satisfaction with Life Scale, and the results of which showed that as: (1) labor values can positively predict life satisfaction, while they are negatively correlated with psychological distress; (2) social support can play a mediating role between labor values and life satisfaction; and (3) social support can also play a mediating role in the relationship between labor values and psychological distress. This study revealed that the specific path and mechanism of labor values on mental health. This provided a reference for families and schools to further implement the education of labor values on primary and secondary school students and helped to promote the social construction of an education system that aimed at cultivating individual all-round development.
Loneliness, Escapism, and Identification With Media Characters: An Exploration of the Psychological Factors Underlying Binge-Watching Tendency
Authors: Gabbiadini Alessandro , Baldissarri Cristina , Valtorta Roberta Rosa , Durante Federica , Mari Silvia
Published: December 2021

Nowadays, binge-watching (i.e., watching multiple episodes of a TV series in one session) has become a widespread practice of media consumption, raising concerns about its negative outcomes. Nevertheless, previous research has overlooked the underlying psychological mechanisms leading to binge-watching. In the present work, we investigated some of the psychological variables that could favor binge-watching tendencies in a sample of TV series viewers (N = 196). To this aim, psychological determinants of problematic digital technologies usage (i.e., feelings of loneliness), as well as some of the mechanisms related to the enjoyment of media contents (i.e., escapism and the identification with media characters), were considered as predictors of the tendency to binge-watch. Results indicated that higher feelings of loneliness were associated with higher levels of problematic digital technologies usage. Additionally, direct and indirect effects showed that only escapism – out of the four dimensions measuring the problematic use of Internet-related technologies – predicted participants’ stronger identification with media characters, which in turn promoted greater binge-watching tendencies. Overall, we suggest that binge-watching could be interpreted as a coping strategy for media escapists, who enjoy TV series as a privileged online space in which the need to escape finds its fulfillment, allowing them to manage loneliness by identifying with a fictitious character.
Research on Unsafe Behavior of Construction Workers Under the Bidirectional Effect of Formal Rule Awareness and Conformity Mentality
Authors: Li Zhen , Bao Xiaoyu , Sheng Yingying , Xia Yu
Published: December 2021

At present, China’s engineering safety management has developed to a certain level, but the number of casualties caused by construction accidents is still increasing in recent years, and the safety problems in the construction industry are still worrying. For purpose of effectively reducing construction workers’ unsafe behavior and improve the efficiency of construction safety management, based on multi-agent modeling, this paper analyzes the influencing factors during construction workers’ cognitive process from the perspective of safety cognition, constructs the interaction and cognition of the agent under the bidirectional effect of formal rule awareness and conformity mentality model, and set behavior rules and parameters through the Net Logo platform for simulation. The results show that: Unsafe behavior of construction workers is related to the failure of cognitive process, and the role of workers’ psychology and consciousness will affect the cognitive process; The higher the level of conformity intention of construction workers, the easier it is to increase the unsafe behavior of the group; Formal rule awareness can play a greater role only when the management standard is at a high level, and can correct the workers’ safety cognition and effectively correct the workers’ unsafe behavior; Under certain construction site environmental risks, the interaction between formal rule awareness and conformity mentality in an appropriate range is conducive to the realization of construction project life cycle management. This study has certain theoretical and practical significance for in-depth understanding of safety cognition and reducing unsafe behavior of construction team.
How Internal Marketing Drives Employees’ Internal Relationship Quality of Service Organizations Between Mainland China and Taiwan: The Moderating Roles of Internal Relationship Investment and Leader-Member Exchange
Authors: Li Yunhe , Xiong Minghua , Chang Wei-Hsuan , Li Ling
Published: December 2021

Recently, issues of human resource management gradually attract a lot of attention from organizational behavior scholars, thus how to effectively improve service employees’ job attitude and performance to meet the needs of stakeholders is one of the key issues in internal marketing. Based on the perspective of internal marketing, the study transforms the relevant factors applied to maintaining external customer relations into internal employee-oriented factors, so as to increase the understanding of the relationship between internal service recovery and internal relationship quality (IRQ). This study aims to explore (1) whether internal service recovery enhances IRQ; (2) whether internal relationship investment (IRI) positively moderates relationship between internal service recovery and IRQ; and (3) whether effectiveness of internal service recovery differentiates under different exchange relationship (high/low quality leader-member exchange). In this study, a total of 206 Mainland China and 250 Taiwanese participants were collected. In this study, a variance-based structural equation modeling (PLS-SEM) was performed to test the proposed hypothesizes and conduct comparative analysis. Empirical results in both samples show that internal service recovery has positive and significant effects on IRQ; internal relationship investment and leader-member exchange (LMX) positively and significantly moderate the relationship between internal service recovery and IRQ. Finally, based on the results, this study provides some discussions, suggestions and managerial implications for future studies in organizational management.
Multimodal Interventions Are More Effective in Improving Core Symptoms in Children With ADHD
Authors: Ning Ke , Wang Tingzhao
Published: December 2021

Objective: To investigate the effect of sensory integration training combined with EEG biofeedback on core symptoms in children with ADHD.

Methods: Fifty-two children with attention-deficit, hyperactive-impulsive and combined ADHD were selected. They were randomly divided into control group, sensory integration training group, EEG biofeedback group, and sensory integration training + EEG biofeedback group, and after 4 months of intervention, concentration time and impulsive- hyperactivity and hyperactivity index scores on the PSQ scale were assessed.

Results: Compared with that before the intervention, the attention time was significantly increased (P < 0.01), and the impulsive-hyperactivity and hyperactivity index scores were significantly decreased (P < 0.05, P < 0.01). After the intervention, the attention time was significantly higher than that of the control group (P < 0.05, P < 0.01), the attention time of the multimodal intervention group was significantly higher than that of the single intervention group (P < 0.01), and the impulsive-hyperactivity and hyperactivity index scores were significantly lower than those of the single intervention group (P < 0.05).

Conclusion: Multimodal intervention can significantly improve the concentration level of children with ADHD, and significantly improve the behavioral symptoms of impulsive-hyperactivity and hyperactivity. Multimodal interventions were more effective than single interventions in improving core symptoms in children with ADHD. The results of this study provide a reference for related research and practical application.
Risk Factors for Criminal Recidivism Among Persons With Serious Psychiatric Diagnoses: Disentangling What Matters for Whom
Authors: Jacobs Leah A. , Fixler Alex , Labrum Travis , Givens Ashley , Newhill Christina
Published: December 2021

Reducing criminal legal system involvement requires an understanding of the factors that promote repeat offending (i. e., recidivism), and the dissemination of relevant interventions to those most likely to benefit. A growing body of research has established common recidivism risk factors for persons with serious psychiatric disorder diagnoses. However, research to date has not examined the degree to which these risks apply to those with serious psychiatric disorders with and without co-occurring substance use disorders. To clarify what risk and need factors are greatest and for whom, this cross-sectional study drew from an original dataset containing data on 14 social and economic, psychological, and criminal risk areas for a cohort of people on probation (n = 4,809). Linear regression models indicated that, compared to those without a serious psychiatric disorder, people on probation with a serious psychiatric disorder are at greater risk in a minority of areas and those areas are mostly social and economic in nature. Meanwhile, those withco-occurring disorders are at relatively high risk across almost all areas. The results from this study suggest that justice involved persons with serious psychiatric disorders will benefit from interventions that increase social support and economic well-being and that interventions that broadly reduce risk among people with co-occurring serious psychiatric and substance use disorders will likely yield meaningful reductions in system involvement. Ultimately, understanding and intervening upon risk for recidivism among persons with serious psychiatric disorders requires differentiating between those with and without co-occurring substance use disorders.
The Role of Attitudes Toward Medication and Treatment Adherence in the Clinical Response to LAIs: Findings From the STAR Network Depot Study
Authors: Aguglia Andrea , Fusar-Poli Laura , Amerio Andrea , Placenti Valeria , Concerto Carmen , Martinotti Giovanni , Carrà Giuseppe , Bartoli Francesco , D'Agostino Armando , Serafini Gianluca , Amore Mario , Aguglia Eugenio , Ostuzzi Giovanni , Barbui Corrado ,   The STAR Network Investigators
Published: December 2021

Background: Long-acting injectable (LAI) antipsychotics are efficacious in managing psychotic symptoms in people affected by severe mental disorders, such as schizophrenia and bipolar disorder. The present study aimed to investigate whether attitude toward treatment and treatment adherence represent predictors of symptoms changes over time.

Methods: The STAR Network “Depot Study” was a naturalistic, multicenter, observational, prospective study that enrolled people initiating a LAI without restrictions on diagnosis, clinical severity or setting. Participants from 32 Italian centers were assessed at three time points: baseline, 6-month, and 12-month follow-up. Psychopathological symptoms, attitude toward medication and treatment adherence were measured using the Brief Psychiatric Rating Scale (BPRS), the Drug Attitude Inventory (DAI-10) and the Kemp's 7-point scale, respectively. Linear mixed-effects models were used to evaluate whether attitude toward medication and treatment adherence independently predicted symptoms changes over time. Analyses were conducted on the overall sample and then stratified according to the baseline severity (BPRS < 41 or BPRS ≥ 41).

Results: We included 461 participants of which 276 were males. The majority of participants had received a primary diagnosis of a schizophrenia spectrum disorder (71.80%) and initiated a treatment with a second-generation LAI (69.63%). BPRS, DAI-10, and Kemp's scale scores improved over time. Six linear regressions—conducted considering the outcome and predictors at baseline, 6-month, and 12-month follow-up independently—showed that both DAI-10 and Kemp's scale negatively associated with BPRS scores at the three considered time points. Linear mixed-effects models conducted on the overall sample did not show any significant association between attitude toward medication or treatment adherence and changes in psychiatric symptoms over time. However, after stratification according to baseline severity, we found that both DAI-10 and Kemp's scale negatively predicted changes in BPRS scores at 12-month follow-up regardless of baseline severity. The association at 6-month follow-up was confirmed only in the group with moderate or severe symptoms at baseline.

Conclusion: Our findings corroborate the importance of improving the quality of relationship between clinicians and patients. Shared decision making and thorough discussions about benefits and side effects may improve the outcome in patients with severe mental disorders.
The Epidemic of Sexually Transmitted Diseases Under the Influence of COVID-19 in China
Authors: Yan Xiangyu , Wang Xuechun , Zhang Xiangyu , Wang Lei , Zhang Bo , Jia Zhongwei
Published: December 2021

Background: Prevention and control of HIV/AIDS and other sexually transmitted diseases (STDs) are major public health priorities in China, but are influenced by the COVID-19 epidemic. In this study, we aimed to quantitatively explore the impact of the COVID-19 epidemic and its control measures on five major STD epidemics in China.

Methods: A monthly number of newly reported cases of HIV/AIDS, hepatitis B and C, gonorrhea, and syphilis from January 2010 to December 2020 were extracted to establish autoregressive integrated moving average (ARIMA) models. Each month's absolute percentage error (APE) between the actual value and model-predicted value of each STD in 2020 was calculated to evaluate the influence of the COVID-19 epidemic on the STDs. Pearson correlation analysis was conducted to explore the confirmed COVID-19 case numbers and the COVID-19 control measures' correlations with the case numbers and the APEs of five STDs in 2020.

Results: The actual number of five STDs in China was more than 50% lower than the predicted number in the early days of the COVID-19 epidemic, especially in February. Among them, the actual number of cases of hepatitis C, gonorrhea, and syphilis in February 2020 was more than 100% lower than the predicted number (APE was −102.3, −109.0, and −100.4%, respectively). After the sharply declines of STDs' reported cases in early 2020, the case numbers recovered quickly after March. The epidemic of STDs was negatively associated with the COVID-19 epidemic and its control measures, especially for restrictions on gathering size, close public transport, and stay-at-home requirements (p < 0.05).

Conclusion: COVID-19 had a significant but temporary influence on the STD epidemic in China. The effective control of COVID-19 is vital for STD prevention. STD services need to be improved to prevent STDs from becoming a secluded corner in the shadow of COVID-19.
Impact of Mental Health on Wellness in Adult Workers
Authors: Hwang Won Ju , Jo Hyun Hee
Published: December 2021

Wellness in adult workers is intimately associated with better quality of life in individuals, as well as in the family, community, workplace, and country. This study aimed to examine the status of wellness in adult workers and to identify the factors that influence wellness. A descriptive survey was conducted with 260 adult workers. T- test and one-way ANOVA with post-hoc Scheffe test were used to analyze the data. Multiple regression analysis was performed on stress, depression, anxiety, well-being, self-efficacy, and perceived health status. The regression model for wellness in adult workers was significant (F = 42.21, p < 0.001), with an explanatory power of 0.558. Depression (β = −0.306) was identified as the most influential factor for wellness in adult workers, followed by self-efficacy (β = 0.280) and well-being (β = 0.264). Depression, stress, and anxiety negatively influenced wellness, whereas self-efficacy, well-being, and perceived health status positively influenced wellness. Study findings suggest the need to develop intervention programs for workers that decrease stress, depression, and anxiety, and incorporate self-efficacy strategies.
Considerations for the Safe Operation of Schools During the Coronavirus Pandemic
Authors: Lordan Ronan , Prior Samantha , Hennessy Elizabeth , Naik Amruta , Ghosh Soumita , Paschos Georgios K. , Skarke Carsten , Barekat Kayla , Hollingsworth Taylor , Juska Sydney , Mazaleuskaya Liudmila L. , Teegarden Sarah , Glascock Abigail L. , Anderson Sean , Meng Hu , Tang Soon-Yew , Weljie Aalim , Bottalico Lisa , Ricciotti Emanuela , Cherfane Perla , Mrcela Antonijo , Grant Gregory , Poole Kristen , Mayer Natalie , Waring Michael , Adang Laura , Becker Julie , Fries Susanne , FitzGerald Garret A. , Grosser Tilo
Published: December 2021

During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, providing safe in-person schooling has been a dynamic process balancing evolving community disease burden, scientific information, and local regulatory requirements with the mandate for education. Considerations include the health risks of SARS-CoV-2 infection and its post-acute sequelae, the impact of remote learning or periods of quarantine on education and well-being of children, and the contribution of schools to viral circulation in the community. The risk for infections that may occur within schools is related to the incidence of SARS-CoV-2 infections within the local community. Thus, persistent suppression of viral circulation in the community through effective public health measures including vaccination is critical to in-person schooling. Evidence suggests that the likelihood of transmission of SARS-CoV-2 within schools can be minimized if mitigation strategies are rationally combined. This article reviews evidence-based approaches and practices for the continual operation of in-person schooling.
Surgical Treatment of Radial Nerve Injuries Associated With Humeral Shaft Fracture—A Single Center Experience
Authors: Rasulić Lukas , Djurašković Slavko , Lakićević Novak , Lepić Milan , Savić Andrija , Grujić Jovan , Mićić Aleksa , Radojević Stefan , Puzović Vladimir , Maletić Miloš , Mandić-Rajčević Stefan
Published: December 2021

Radial nerve injuries are often associated with humeral shaft fractures. The results of treatment of these injuries, by contemporary surgical approaches, remain diverse. In this paper we presented the outcomes and analyzed the patient, clinical, and surgical procedure related characteristics and factors that may influence the outcome overall, in 77 patients treated at Clinic for Neurosurgery, Clinical Center of Serbia during a 20 years period. The nerve injuries were verified by US and EMNG. The majority of patients were treated by neurolysis or sural nerve grafting, while only few were treated by direct suture. The final recovery was evaluated by muscle strength assessment and classified using MRC. We analyzed extension of the wrist, extension of the fingers including the thumb, and abduction of the thumb. There was a significant statistical difference in MRC grade following the treatment. The total rate of useful functional recovery was achieved in 69 (89.61%) out of all studied patients, out of whom 20 (28.99%) achieved excellent recovery, 26 (37.68%) achieved good recovery and 23 (33.33%) achieved fair recovery. Only 8 (10.39%) out of all studied patients achieved poor recovery. The injured nerves, that were preserved in continuity, acquired by a low-energy trauma, and treated earlier than the 6 months were associated with better functional outcome following the surgery. In addition, there was a trend of better functional improvement with aging, keeping in mind that the old were subjected to lower energy trauma. The expectant management followed by surgery of radial nerve injury associated with humeral shaft fracture should be around 3 months, and the surgical nerve repair should not be performed later than the 6 months after injury. The energy of trauma may be a factor predicting patient's final recovery following the treatment.
Molecular Characterization of Burned Organic Matter at Different Soil Depths and Its Relationship with Soil Water Repellency: A Preliminary Result
Authors: de Deus Mirian , Miller Ana Z. , Jiménez-Morillo Nicasio T.
Published: December 2021

Soil water repellency (hydrophobicity) prevents water from wetting or infiltrating soils, triggering changes in the ecosystems. This physical property is directly correlated to the erodibility grade of a soil. Wildfire events may develop, enhance, or destroy soil hydrophobicity, modifying the erodibility grade of a soil and increasing the loss of its most reactive layer (organic matter). To assess the main organic family of compounds (biomarkers) surrogates to fire-induced water repellency, a study was carried out on a fire-affected soil under eucalyptus canopy at two depths (0–2 and 2–5 cm) from Portugal. The potential soil water repellency was measured using the water drop penetration time (WDPT) test. The molecular characterization of hydrophobic biomarkers was carried out using analytical pyrolysis (Py-GC/MS) in combination with multivariate statistical analysis (PCA, MLR). The upper burned soil layer (0–2 cm) displayed a significant contribution of fresh biomass (lignin and polysaccharides), while the deepest (2–5 cm) one showed more humified organic matter (lipids). The soil hydrophobicity was directly correlated to non-polar organic compounds, such as lipids and polycyclic aromatic hydrocarbons (PAHs), and inversely to unspecific aromatic compounds. The combination of mass spectrometry techniques and chemometric analysis allowed obtaining a preliminary forecast model of hydrophobicity degree in fire-affected soil samples under eucalyptus canopy. This analytical approach opens the door to developing more sensitive mathematical models using molecular organic compounds to predict the alteration of hydrophobicity and other soil physical properties induced by fires.
Investigating the OXA Variants of ESKAPE Pathogens
Authors: Pandey Deeksha , Singhal Neelja , Kumar Manish
Published: December 2021

ESKAPE pathogens are the leading cause of nosocomial infections. The Global Priority List of WHO has categorized ESKAPE as priority 1 and 2 pathogens. Even though several mechanisms contribute to antimicrobial resistance, OXA β-lactamase has emerged as a new threat in combating nosocomial infections. In the present study we have investigated the presence of OXA and their variants, copy number, distribution on chromosomes/plasmids, subfamilies, phylogenetic relationships, amino acid identities and variabilities in ESKAPE pathogens. Our results revealed that a total of 929 OXA were present in 2258 completely assembled genomes, which could be further subdivided into 16 sub-families. Among all the ESKAPE pathogens, OXA were highly prevalent in A. baumannii, followed by P. aeruginosa and K. pneumoniae but completely absent in E. faecium and S. aureus while, only a few copies were found in Enterobacter spp. Most of the OXA variants belonged to the OXA-51-like subfamily (200 proteins), followed by OXA-50-like subfamily (189 proteins), OXA-23-like subfamily (156 proteins) and OXA-1-like subfamily (154 proteins). OXA-51-like, OXA-213-like, OXA-134-like, OXA-58-like, OXA-24-like and OXA-20-like subfamilies were present exclusively in A. baumannii. Phylogenetic tree of the subfamilies revealed that OXA-1-like and OXA-33-like, OXA-51-like and OXA-213-like and, OXA-5-like and OXA-10-like belonged to the same branches with amino acid identities as 100%, 97.10% and 80.90% respectively. This indicates that the members of these subfamily-pairs might have evolved from the same ancestor or have recently diverged. Thus, a judicious use of carbapenems is warranted to curtail the rise of new OXA enzymes and preserve them. This is the first detailed report about the OXA of ESKAPE pathogens.
Predicting the Effects of Solar Storms on the Ionosphere Based on a Comparison of Real-Time Solar Wind Data with the Best-Fitting Historical Storm Event
Authors: Schmölter Erik , Berdermann Jens
Published: December 2021

This study presents a new modeling approach that aims for long time predictions (more than 12 h) of ionospheric disturbances driven by solar storm events. The proposed model shall run in an operational framework to deliver fast and precise localized warnings for these disturbances in the future. The solar wind data driven approach uses a data base of historical solar storm impacts covering two solar cycles to reconstruct future events and resulting ionospheric disturbances. The basic components of the model are presented and discussed in this study, and the strengths of the reconstruction based on historical events are presented by showing the good correlations for predicted and observed geomagnetic activity. Initial results on the ionospheric response are discussed for all historical events using global total electron content (GTEC) and in more detail using total electron content (TEC) maps for two specific case studies (including the St. Patrick’s Day geomagnetic storm during the 17 March 2015). Average root mean square error (RMSE) values of 3.90 and 5.21 TECU are calculated for these cases confirming good results for the current configuration of the model. Possible future improvements of the individual model parts, as well as the planned extensions and applications are discussed in detail.
Terrain Effects on Regional Precipitation in a Warm Season over Qinling-Daba Mountains in Central China
Authors: Li Xiaofei , Wang Ninglian , Wu Zhanhao
Published: December 2021

The terrain effects of Qinling–Daba Mountains on reginal precipitation during a warm season were investigated in a two-month day-to-day experiment using the Weather Research and Forecasting (WRF) model. According to the results from the terrain sensitivity experiment with lowered mountains, Qinling–Daba Mountains have been found to have an obvious effect on both the spatial-temporal distribution and diurnal cycle of reginal precipitation from July to August in 2019, where the Qinling Mountains mainly enhanced the precipitation around 34° N, and the Daba Mountains mainly enhanced it around 32° N at the time period of early morning and midnight. Horizontal distribution of water vapor and convective available potential energy (CAPE), as well as cross section of vertical velocity of wind and potential temperature has been studied to examine the key mechanisms for these two mountains’ effect. The existence of Qinling Mountains intercepted transportation of water vapor from South to North in the lower troposphere to across 34° N and caused an obvious enhancement of CAPE in the neighborhood, while the Daba Mountains intercepted the northward water vapor transportation to across 32° N and caused an enhanced CAPE nearby. The time period of the influence is in a good accordance with the diurnal cycle. In the cross-section, the existence of Qinling Mountains and Daba Mountains are found to stimulate the upward motion and unstable environment effectively at around 34° N and 32° N, separately. As a result, the existence of the two mountains lead to a favorable environment in water vapor, thermodynamic, and dynamic conditions for this warm season precipitation.
Online Chemical Characterization and Sources of Submicron Aerosol in the Major Mediterranean Port City of Piraeus, Greece
Authors: Stavroulas Iasonas , Grivas Georgios , Liakakou Eleni , Kalkavouras Panayiotis , Bougiatioti Aikaterini , Kaskaoutis Dimitris G. , Lianou Maria , Papoutsidaki Kyriaki , Tsagkaraki Maria , Zarmpas Pavlos , Gerasopoulos Evangelos , Mihalopoulos Nikolaos
Published: December 2021

Port cities are affected by a wide array of emissions, including those from the shipping, road transport, and residential sectors; therefore, the characterization and apportionment of such sources in a high temporal resolution is crucial. This study presents measurements of fine aerosol chemical composition in Piraeus, one of the largest European ports, during two monthly periods (winter vs. summer) in 2018–2019, using online instrumentation (Aerosol Chemical Speciation Monitor—ACSM, 7-λ aethalometer). PMF source apportionment was performed on the ACSM mass spectra to quantify organic aerosol (OA) components, while equivalent black carbon (BC) was decomposed to its fossil fuel combustion and biomass burning (BB) fractions. The combined traffic, shipping and, especially, residential emissions led to considerably elevated submicron aerosol levels (22.8 μg m−3) in winter, which frequently became episodic late at night under stagnant conditions. Carbonaceous compounds comprised the major portion of this submicron aerosol in winter, with mean OA and BC contributions of 61% (13.9 μg m−3) and 16% (3.7 μg m−3), respectively. The contribution of BB to BC concentrations was considerable and spatially uniform. OA related to BB emissions (fresh and processed) and hydrocarbon-like OA (from vehicular traffic and port-related fossil fuel emissions including shipping) accounted for 37% and 30% of OA, respectively. In summer, the average PM1 concentration was significantly lower (14.8 μg m−3) and less variable, especially for the components associated with secondary aerosols (such as OA and sulfate). The effect of the port sector was evident in summer and maintained BC concentrations at high levels (2.8 μg m−3), despite the absence of BB and improved atmospheric dispersion. Oxygenated components yielded over 70% of OA in summer, with the more oxidized secondary component of regional origin being dominant (41%) despite the intensity of local sources, in the Piraeus environment. In general, with respect to local sources that can be the target of mitigation policies, this work highlights the importance of port-related activities but also reveals the extensive wintertime impact of residential wood burning. While a separation of the BB source is feasible, more research is needed on how to disentangle the short-term effects of different fossil-fuel combustion sources.
Semantic Trajectory Analytics and Recommender Systems in Cultural Spaces
Authors: Angelis Sotiris , Kotis Konstantinos , Spiliotopoulos Dimitris
Published: December 2021

Semantic trajectory analytics and personalised recommender systems that enhance user experience are modern research topics that are increasingly getting attention. Semantic trajectories can efficiently model human movement for further analysis and pattern recognition, while personalised recommender systems can adapt to constantly changing user needs and provide meaningful and optimised suggestions. This paper focuses on the investigation of open issues and challenges at the intersection of these two topics, emphasising semantic technologies and machine learning techniques. The goal of this paper is twofold: (a) to critically review related work on semantic trajectories and knowledge-based interactive recommender systems, and (b) to propose a high-level framework, by describing its requirements. The paper presents a system architecture design for the recognition of semantic trajectory patterns and for the inferencing of possible synthesis of visitor trajectories in cultural spaces, such as museums, making suggestions for new trajectories that optimise cultural experiences.
Relevance of Dynamic 18F-DOPA PET Radiomics for Differentiation of High-Grade Glioma Progression from Treatment-Related Changes
Authors: Ahrari Shamimeh , Zaragori Timothée , Rozenblum Laura , Oster Julien , Imbert Laëtitia , Kas Aurélie , Verger Antoine
Published: December 2021

This study evaluates the relevance of 18F-DOPA PET static and dynamic radiomics for differentiation of high-grade glioma (HGG) progression from treatment-related changes (TRC) by comparing diagnostic performances to the current PET imaging standard of care. Eighty-five patients with histologically confirmed HGG and investigated by dynamic 18F-FDOPA PET in two institutions were retrospectively selected. ElasticNet logistic regression, Random Forest and XGBoost machine models were trained with different sets of features—radiomics extracted from static tumor-to-background-ratio (TBR) parametric images, radiomics extracted from time-to-peak (TTP) parametric images, as well as combination of both—in order to discriminate glioma progression from TRC at 6 months from the PET scan. Diagnostic performances of the models were compared to a logistic regression model with TBRmean ± clinical features used as reference. Training was performed on data from the first center, while external validation was performed on data from the second center. Best radiomics models showed only slightly better performances than the reference model (respective AUCs of 0.834 vs. 0.792, p < 0.001). Our current results show similar findings at the multicentric level using different machine learning models and report a marginal additional value for TBR static and TTP dynamic radiomics over the classical analysis based on TBR values.
C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency
Authors: Fee Laura T. , Gogoi Debananda , O’Brien Michael E. , McHugh Emer , Casey Michelle , Gough Ciara , Murphy Mark , Hopkins Ann M. , Carroll Tomás P. , McElvaney Noel G. , Reeves Emer P.
Published: December 2021

Alpha-1 antitrypsin (AAT) deficiency (AATD) is characterized by increased risk for emphysema, chronic obstructive pulmonary disease (COPD), vasculitis, and wound-healing impairment. Neutrophils play a central role in the pathogenesis of AATD. Dysregulated complement activation in AATD results in increased plasma levels of C3d. The current study investigated the impact of C3d on circulating neutrophils. Blood was collected from AATD (n = 88) or non-AATD COPD patients (n = 10) and healthy controls (HC) (n = 40). Neutrophils were challenged with C3d, and degranulation was assessed by Western blotting, ELISA, or fluorescence resonance energy transfer (FRET) substrate assays. Ex vivo, C3d levels were increased in plasma (p < 0.0001) and on neutrophil plasma membranes (p = 0.038) in AATD compared to HC. C3d binding to CR3 receptors triggered primary (p = 0.01), secondary (p = 0.004), and tertiary (p = 0.018) granule release and increased CXCL8 secretion (p = 0.02). Ex vivo plasma levels of bactericidal-permeability-increasing-protein (p = 0.02), myeloperoxidase (p < 0.0001), and lactoferrin (p < 0.0001) were significantly increased in AATD patients. In endothelial cell scratch wound assays, C3d significantly decreased cell migration (p < 0.0001), an effect potentiated by neutrophil degranulated proteins (p < 0.0001). In summary, AATD patients had increased C3d in plasma and on neutrophil membranes and, together with neutrophil-released granule enzymes, reduced endothelial cell migration and wound healing, with potential implications for AATD-related vasculitis.
Unraveling Autocrine Signaling Pathways through Metabolic Fingerprinting in Serous Ovarian Cancer Cells
Authors: Ha Ji Hee , Jayaraman Muralidharan , Nadhan Revathy , Kashyap Srishti , Mukherjee Priyabrata , Isidoro Ciro , Song Yong Sang , Dhanasekaran Danny N.
Published: December 2021

Focusing on defining metabolite-based inter-tumoral heterogeneity in ovarian cancer, we investigated the metabolic diversity of a panel of high-grade serous ovarian carcinoma (HGSOC) cell-lines using a metabolomics platform that interrogate 731 compounds. Metabolic fingerprinting followed by 2-dimensional and 3-dimensional principal component analysis established the heterogeneity of the HGSOC cells by clustering them into five distinct metabolic groups compared to the fallopian tube epithelial cell line control. An overall increase in the metabolites associated with aerobic glycolysis and phospholipid metabolism were observed in the majority of the cancer cells. A preponderant increase in the levels of metabolites involved in trans-sulphuration and glutathione synthesis was also observed. More significantly, subsets of HGSOC cells showed an increase in the levels of 5-Hydroxytryptamine, γ-aminobutyrate, or glutamate. Additionally, 5-hydroxytryptamin synthesis inhibitor as well as antagonists of γ-aminobutyrate and glutamate receptors prohibited the proliferation of HGSOC cells, pointing to their potential roles as oncometabolites and ligands for receptor-mediated autocrine signaling in cancer cells. Consistent with this role, 5-Hydroxytryptamine synthesis inhibitor as well as receptor antagonists of γ-aminobutyrate and Glutamate-receptors inhibited the proliferation of HGSOC cells. These antagonists also inhibited the three-dimensional spheroid growth of TYKNU cells, a representative HGSOC cell-line. These results identify 5-HT, GABA, and Glutamate as putative oncometabolites in ovarian cancer metabolic sub-type and point to them as therapeutic targets in a metabolomic fingerprinting-based therapeutic strategy.
Expression of SnoRNA U50A Is Associated with Better Prognosis and Prolonged Mitosis in Breast Cancer
Authors: Li Jie-Ning , Wang Ming-Yang , Chen Yi-Ting , Kuo Yao-Lung , Chen Pai-Sheng
Published: December 2021

Small nucleolar RNAs (snoRNAs) are small noncoding RNAs generally recognized as housekeeping genes. Genomic analysis has shown that snoRNA U50A (U50A) is a candidate tumor suppressor gene deleted in less than 10% of breast cancer patients. To date, the pathological roles of U50A in cancer, including its clinical significance and its regulatory impact at the molecular level, are not well-defined. Here, we quantified the copy number of U50A in human breast cancer tissues. Our results showed that the U50A expression level is correlated with better prognosis in breast cancer patients. Utilizing RNA-sequencing for transcriptomic analysis, we revealed that U50A downregulates mitosis-related genes leading to arrested cancer cell mitosis and suppressed colony-forming ability. Moreover, in support of the impacts of U50A in prolonging mitosis and inhibiting clonogenic activity, breast cancer tissues with higher U50A expression exhibit accumulated mitotic tumor cells. In conclusion, based on the evidence from U50A-downregulated mitosis-related genes, prolonged mitosis, repressed colony-forming ability, and clinical analyses, we demonstrated molecular insights into the pathological impact of snoRNA U50A in human breast cancer.
Differences in Internet Use and eHealth Needs of Adolescent and Young Adult Versus Older Cancer Patients; Results from the PROFILES Registry
Authors: Vlooswijk Carla , Husson Olga , Krahmer Emiel J. , Bijlsma Rhodé , Kaal Suzanne E. J. , Sleeman Sophia H. E. , van de Poll-Franse Lonneke V. , van der Graaf Winette T. A. , Bol Nadine , van Eenbergen Mies C.
Published: December 2021

Background: Our aim was to evaluate differences in cancer-related internet patterns between AYAs (adolescents and young adults; 18–39 years at time of diagnosis) and older adult cancer patients (40+ years). Methods: Cross-sectional surveys were distributed among AYA and older adult cancer patients regarding cancer-related internet use and eHealth needs. Results: 299 AYAs (mean age 31.8 years) and 270 older adults (mean age 55.8 years) participated. AYAs searched significantly more often on the internet on a daily basis just before diagnosis (45% vs. 37%), right after diagnosis (71% vs. 62%) and during treatment (65% vs. 59%) compared to older adults. During follow up, there was a trend that AYAs searched less often on the internet compared to older adults (15% vs. 17%). AYAs searched more often on topics, such as alternative or complementary therapies, treatment guidelines, fertility, end of life, sexuality and intimacy, lifestyle and insurance. AYAs felt significantly better informed (75%) after searching for cancer-related information compared to older adults (65%) and had significantly less unmet needs regarding access to their own medical information (22% vs. 47%). AYAs search more on the internet on a daily basis/several times per week in the diagnosis and treatment phase than older cancer patients. They search on different topics than older adults and seems to have less unmet eHealth needs.It is important that these are easy to find and reliable.