bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract P505: Rv Sarcomeres From Lv-hfref Patients With Low Papi Have Abnormal Rv Thick Filament Structure
Authors: Jani Vivek , Aslam Mohammed I , Ma Weikang , Gong Henry , Cammarato Anthony , Irving Thomas , Kass David A , Hsu Steven
Published: November 2021

Patients with left heart failure and reduced ejection fraction (HFrEF) have variable RV failure that, if present, drastically worsens outcomes. In a cohort of 21 HFrEF patients from two hospital sites, we have previously shown (Aslam et al, Eur J HF; 2020: volume 23, pages 339-341) that like global function, RV myocyte maximum calcium-activated myocyte tension (T
max
) is quite variable (COV 27%). To determine if a relationship between RV myocyte function and indices of RV chamber function exists, we trained a random forest classifier based on 41 clinical variables, including hemodynamic, laboratory, and echocardiographic data, and queried the importance of each. This revealed that the most predictive model for reduced T
max
was based on the pulmonary artery pulsatility index (PAPi), an established clinical index of RV failure. To gain insight into potential mechanisms for depressed T
max
in HFrEF patients with a low PAPi, we obtained small angle x-ray diffraction patterns in 5 HFrEF patients with depressed PAPi and T
max
and compared this to 5 non-failing (NF) controls. The equatorial intensity ratio I(1,1)/I(1,0) was reduced in low T
max
RV muscle fibers vs. controls (0.250.06 vs. 0.180.02, P<0.0001), suggesting myosin heads are more associated with the thick filament backbone. In meridional reflections, we find a significant decrease in M3 band spacing (14.340.03 nm in NF vs. 14.300.01 nm in HFrEF; P=0.0013) suggesting more myosin heads are in the “OFF” configuration. The latter may underly tension reduction in RV myocytes from failing RV HFrEF patients. Ongoing studies will examine these structural changes in HFrEF patients with a broader range of PAPi and T
max
to test if this association applies. These findings focus attention on thick filament structural and configuration abnormalities as potential culprits underlying RV disease in HFrEF. Further studies using novel sarcomere enhancers will test if these changes can be remedied, and if so, in which patients.
Adenosine A1R/A3R (Adenosine A1 and A3 Receptor) Agonist AST-004 Reduces Brain Infarction in a Nonhuman Primate Model of Stroke
Authors: Liston Theodore E. , Hama Aldric , Boltze Johannes , Poe Russell B. , Natsume Takahiro , Hayashi Ikuo , Takamatsu Hiroyuki , Korinek William S. , Lechleiter James D.
Published: November 2021

Background and Purpose:

Treatment with A1R/A3R (adenosine A1 and A3 receptor) agonists in rodent models of acute ischemic stroke results in significantly reduced lesion volume, indicating activation of adenosine A1R or A3R is cerebroprotective. However, dosing and timing required for cerebroprotection has yet to be established, and whether adenosine A1R/A3R activation will lead to cerebroprotection in a gyrencephalic species has yet to be determined.

Methods:

The current study used clinical study intervention timelines in a nonhuman primate model of transient, 4-hour middle cerebral artery occlusion to investigate a potential cerebroprotective effect of the dual adenosine A1R/A3R agonist AST-004. Bolus and then 22 hours intravenous infusion of AST-004 was initiated 2 hours after transient middle cerebral artery occlusion. Primary outcome measures included lesion volume, lesion growth kinetics, penumbra volume as well as initial pharmacokinetic-pharmacodynamic relationships measured up to 5 days after transient middle cerebral artery occlusion. Secondary outcome measures included physiological parameters and neurological function.

Results:

Administration of AST-004 resulted in rapid and statistically significant decreases in lesion growth rate and total lesion volume. In addition, penumbra volume decline over time was significantly less under AST-004 treatment compared with vehicle treatment. These changes correlated with unbound AST-004 concentrations in the plasma and cerebrospinal fluid as well as estimated brain A1R and A3R occupancy. No relevant changes in physiological parameters were observed during AST-004 treatment.

Conclusions:

These findings suggest that administration of AST-004 and combined A1R/A3R agonism in the brain are efficacious pharmacological interventions in acute ischemic stroke and warrant further clinical evaluation.
On the taxonomy of Afrotropical Coleophoridae (VI). New species of the genus Coleophora Hübner, 1822 from South Africa (Lepidoptera, Coleophoridae)
Authors: BALDIZZONE GIORGIO
Published: November 2021

This work presents the description of 16 new species of the genus Coleophora Hübner from the Republic of South Africa: Coleophora animula sp. nov., C. parvula sp. nov., C. coniella sp. nov., C. afrobrunnea sp. nov., C. rocherpanensis sp. nov., C. comparata sp. nov., C. richtersveldi sp. nov., C. incomparabilis sp. nov., C. dixella sp. nov., C. cederbergensis sp. nov., C. curviphallica sp. nov., C. notabilis sp. nov., C. quaggaefontis sp. nov., C. tabulensis sp. nov., C. intricata sp. nov., C. transvaalensis sp. nov. A checklist of the 71 species currently known for South Africa is provided.
Taxonomic changes in the Neotropical Arctiinae, Arctiini (Lepidoptera, Erebidae) relating to the fauna of Trinidad and Tobago
Authors: COCK MATTHEW J.W. , LAGUERRE MICHEL
Published: November 2021

In preparation for a general account of the Trinidad and Tobago Arctiini, the following taxonomic changes are made and justification provided. A lectotype is designated for Castrica sordidior Rothschild, 1909. Castrica oweni Schaus, 1896, stat rev. is returned to species rank. The following new synonyms are established: Castrica sordidior Rothschild, 1909 syn. nov. of Castrica oweni Schaus, 1896; Automolis nigroapicalis Gaede, 1923, Automolis semicostalis Rothschild, 1909, Automolis alboatra Rothschild, 1909, Automolis alboatra borussica Seitz, 1922, Sallaea unifascia Druce, 1899, Automolis hamifera Dognin, 1907, and Automolis apicata Schaus, 1905 syn. nov. of Pryteria costata Möschler, 1883; and Sphinx Adfeit. psamas Cramer, [1779] syn. nov. of Phalaena Noctua onytes Cramer, [1777]. Virbia birchi Druce, 1911 is confirmed to be a synonym of Phalaena medarda Stoll, [1781]. Pryteria tenuis (Rothschild, 1935) stat. nov. and P. intensa (Rothschild, 1935) stat. nov. are raised to species level pending clarification of the genus Pryteria in Central America.
Three new species of Lachesilla in the rufa group (Psocodea: Psocomorpha: Lachesillidae) from the Sierra Tarahumara, Mexico
Authors: ALDRETE ALFONSO NERI GARCÍA , CASASOLA-GONZÁLEZ JOSÉ ARTURO
Published: November 2021

Three species of Lachesilla, in species group rufa, from the Sierra Tarahumara, Chihuahua, Mexico, are here described and illustrated: L. byei n. sp., L. furthi n. sp., and L. raramuri n. sp. Two of them belong in Subgroup IIb of the species group, one showing affinities with L. sommermanae García Aldrete and L. yakima Mockford & García Aldrete, the second one showing affinity with L. salamana García Aldrete. The third species belongs in Subgroup I of the species group, showing affinities with L. aspera García Aldrete and L. chiricahua García Aldrete. The especies here described raise to seven the number of species of Lachesilla in the Sierra Tarahumara.
Construction of lidocaine transmembrane nano-liposomes and preliminary study on its surface anesthetic effect
Authors: Zhang Lirong , Li Wei , Zhao Qingjun , Teng Ruyang
Published: November 2021

Lidocaine (Lido) is an amide local anesthetic that has both excitatory and inhibitory effects on the central nervous system, and is one of a group of commonly used local nerve block drugs that are used in the clinic. However, traditional Lido does not meet the transdermal performance
requirements of surface anesthetic agents for treating pain in patients. Optimizing the preparation of a Lido transdermal preparation and improving the control of anesthetic depth and efficiency has become a challenge in the field of topical anesthesia. In this study, a new type of Lido nano-transdermal
preparation, carboxymethyl chitosan-modified lidocaine liposomes (Lido-CMCSNLP), were constructed based on nano-liposomes. Carboxymethyl chitosan can enhance the permeability of hydrophilic macromolecular pathways by interacting with negatively charged membrane glycoproteins, which is beneficial
for the transdermal absorption of Lido. Therefore, Lido-CMCS-NLP provides a new approach for research in clinical topical anesthesia and perioperative topical analgesics.
Terminalia chebula reduces melanoma cell proliferation and increases apoptosis by inhibiting tyrosinase
Authors: Jian Xingling , Wu Jianlong , Wang Jieyi , Chen Menghui , Mao Yan , Wang Shuangshuang , Yu Bo
Published: November 2021

Recently, research on using plant-derived drugs as anticancer agents has been greatly developed. Terminalia chebula (T. chebula) Retz., the mature fruit of T. chebula, contains active ingredients that have antioxidant, antimicrobial, and antitumor effects. Because traditional
Chinese medicine components have unstable physical and chemical properties, such as poor solubility, fast decomposition, and high irritation, drug nanocarriers that effectively increase their solubility and reduce irritation are desirable. Additionally, T. chebula fruit can inhibit
tyrosinase activity. This study aimed to determine whether T. chebula nanostructured lipid carriers can regulate the proliferation and apoptosis of melanoma cells by inhibiting tyrosinase activity. Tyrosinase activity in drug-treated melanoma cells was detected by MTT and DOPA oxidation
assays, and cell proliferation rate was observed. Western blot (MTT) was used to detect the activity of apoptotic factors, and flow cytometry was used to determine the apoptotic rate. The results showed that tyrosinase activity and cell proliferation rate decreased with increasing drug concentration
in cultured cells. Furthermore, the inhibitory effect was concentration-dependent. Additionally, cells cultured with a high concentration of T. chebula nanostructured lipid carriers could activate apoptotic factors and increase cell apoptosis. Thus, this study showed that T. chebula
fruit nanostructured lipid carriers could inhibit the proliferation of melanoma cells and increase apoptosis by inhibiting tyrosinase activity, demonstrating a new plant-derived drug for melanoma treatment.
Development and field application of downhole crosslinking plugging agent
Authors: Feng Jie , Zheng Lihui , Hao You , Hui Baotong , Yang Hong , Hao Huijun , Liu Fan , Li Long , Li Yingying
Published: November 2021

There were mainly cement slurry, bridge plugging and polymer gel plugging materials for fracture loss circulation and fractured/caved loss circulation. The downhole crosslinking plugging agent was researched for the plugging agents’ respective limitations leaded to low success
rate of plugging and longer construction period. This kind of plug agent is consistent with emulsion, phase inversion agent and crosslinking agent. It could form a high strength elastomer when the plug agent is pumped into the leaking layer and mixed with a certain amount of water. The elastomer
with strong ability could offer good resident ability to reduce cement slurry thickening by underground water and plugging mud, and increased the ratio of success. The experimental results showed that crosslinking time wasn’t affected by temperature, salt water, drilling cuttings, bentonite
mud and other pollutants. The plug agent has been successfully used in several wells of the sixth block in Sudan.
Design and formulation of microbially induced self-healing concrete for building structure strength enhancement
Authors: Sundravel K. Vijaya , Ramesh S. , Jegatheeswaran D.
Published: November 2021

Self-healing concrete is described as the capability of material to repair their cracks independently. Cracks in concrete are well-known circumstance because of their short tensile strength. Many researchers carried out their research on self-healing concrete using different classification
and clustering methods. But the temperature variation and pH variation were not minimized. In order to address these problems, a Multivariate Logistic Regressed Chi-Square Deep Recurrent Neural Network based Self-Healing (MLRCSDRNN-SH) Method is introduced. The main aim of MLRCSDRNN-SH method
is to improve building structures strength through inducing the micro-bacteria in concrete. Multiple Logistic Regressed Chi-Square Deep Recurrent Neural Network (MLRCSDRNN) is used to revise bacteria’s stress-strain behaviour towards enhanced material strength in the MLRCSDRNN-SH approach.
Initially, the bacteria selection is carried out in alkaline environment like Bacillus subtilis, E. coli and Pseudomonas sps. The data sample is given to the input layer. The input layer transmits sample to the hidden layer 1. The regression analysis is carried out between the
multiple independent variables (i.e., parameters) using multivariate logistic function for improving the building structure strength. The regressed value is transmitted to the hidden layer 2. The pearson chi-squared independence hypothesis is performed to identify the probability of crack
self-healing property for increasing the building structure strength. When probability value is higher, then the building structure strength is high. Otherwise, the output of second hidden layer is feedback to the input of hidden layer 1. The mixture with higher strength of building structure
is sent to the output layer. Several specimens have different sizes used by various researchers for bacterial material study in comparison with the concrete. Depending on experimental results, compressive strength restoration proved higher self-healing ability of the concrete.
Variability and Drivers of Ocean Temperature Extremes in a Warming Western Boundary Current
Authors: Li Junde , Roughan Moninya , Kerry Colette
Published: November 2021

Western boundary current (WBC) extensions such as the East Australian Current (EAC) southern extension are warming 2–3 times faster than the global average. However, there are nuances in the spatial and temporal variability of the warming that are not well resolved in climate models. In addition, the physical drivers of ocean heat content (OHC) extremes are not well understood. Here, using a high-resolution ocean model run for multiple decades, we show nonuniform warming trends in OHC in the EAC, with strong positive trends in the southern extension region (∼36°–38°S) but negative OHC trends equatorward of 33°S. The OHC variability in the EAC is associated with the formation of anticyclonic eddies, which is modulated by transport ∼880 km upstream (EAC mode) and the westward propagation of Rossby waves (eddy mode). Diagnosing the drivers of temperature extremes has implications for predictability both in the EAC and in WBCs more broadly, where ocean warming is already having considerable ecological impacts.
Peer Network Processes in Adolescents’ Health Lifestyles
Authors: adams jimi , Lawrence Elizabeth M. , Goode Joshua A. , Schaefer David R. , Mollborn Stefanie
Published: November 2021

Combining theories of health lifestyles—interrelated health behaviors arising from group-based identities—with those of network and behavior change, we investigated network characteristics of health lifestyles and the role of influence and selection processes underlying these characteristics. We examined these questions in two high schools using longitudinal, complete friendship network data from the National Longitudinal Study of Adolescent to Adult Health. Latent class analyses characterized each school’s predominant health lifestyles using several health behavior domains. School-specific stochastic actor-based models evaluated the bidirectional relationship between friendship networks and health lifestyles. Predominant lifestyles remained stable within schools over time, even as individuals transitioned between lifestyles. Friends displayed greater similarity in health lifestyles than nonfriend dyads. Similarities resulted primarily from teens’ selection of friends with similar lifestyles but also from teens influencing their peers’ lifestyles. This study demonstrates the salience of health lifestyles for adolescent development and friendship networks.
Geographical and Temporal Distribution of Radiologists, Computed Tomography and Magnetic Resonance Scanners in Croatia
Authors: Biloglav Zrinka , Medaković Petar , Vrkić Dina , Brkljačić Boris , Padjen Ivan , Ćurić Josip , Žuvela Franko , Ivanac Gordana
Published: November 2021

The aim of the study was to analyse the temporal and geographic distribution of radiologists, computed tomography and magnetic resonance scanners in Croatia. In this observational study we estimated radiologists’ number per 100,000 population for 1997, 2006, and 2017 and compared private and public CT and MR scanners between 2011 and 2018. We analyzed the availability of radiologists and scanners, and the relationship between the radiological workforce and economic strength among counties. The workforce increased significantly from 1997 to 2017 and was associated with economic strength categories in 2017. In 2018, there were more CT scanners in the public sector, while MR scanners were distributed evenly. In 2011, there was similar distribution of CT and MR between sectors, while in 2018 there were significantly more public CT scanners. Counties with a medical school had significantly more radiologists and MR scanners. The high-to-low ratios per CT and MR were 11 and 8.2, suggesting inequality of health care. Croatia significantly increased its radiological workforce; however, cross-county inequality remained. Counties with higher economic strength and medical schools have better availability of radiologists and equipment. To ensure the sustainable activity of the health care system, a precise estimate of supply and demand of radiology services is needed.
Energy efficiency path planning for a quadrotor aerial vehicle
Authors: Yacef Fouad , Rizoug Nassim , Degaa Laid , Bouhali Omar , Hamerlain Mustapha
Published: November 2021

Unmanned aerial vehicles are used today in many real-world applications. In all these applications, the vehicle endurance (flight time) is an important constraint that affects mission success. This study investigates the limitations of embedded energy for a quadrotor aerial vehicle. We consider a quadrotor simple tasked to travel from an initial hover configuration to a final hover configuration. In order to have a precise approximation of the consumed energy, we propose a power consumption model with battery dynamic, motor dynamic, and rotor efficiency function. We then introduce an optimization algorithm to minimize the energy consumption during quadrotor aerial vehicle mission. The proposed algorithm is based on an optimal control problem formulated for the quadrotor model and solved using nonlinear programming. In the optimal control problem, we seek to find control inputs (rotor velocity) and vehicle trajectory between initial and final configurations that minimize the consumed energy during a point-to-point mission. We extensively test in simulation experiments the proposed algorithm under normal and windy weather conditions. We compare the proposed optimization method with a nonlinear adaptive control approach to highlight the saved amount of energy.
Job-Search Activities, Job-Seeking Barriers, and Work Experiences of Transition-Age Youths With Visual Impairments
Authors: Cmar Jennifer L. , Steverson Anne
Published: November 2021

Introduction: The purpose of this study was to describe the job-seeking and work experiences of transition-age youths with visual impairments. Methods: We analyzed follow-up data from a quasi-experimental study of a job-search intervention conducted from 2016 to 2019. Participants were 88 youths with visual impairments from three states; approximately half received the job-search intervention, and the other half served as a comparison group. Measures included job-search activities and outcomes, job-seeking barriers, volunteer and work experiences, and parental support for job-seeking. Results: Commonly reported job-search activities were preparing or revising resumes, talking to people about jobs, submitting applications, and submitting resumes, but most participants performed these activities infrequently. Many job-seekers encountered barriers during their job search, and few searches resulted in paid employment. Participants generally reported moderate levels of preparation to handle job-seeking barriers and parental support for job-seeking. Intervention and comparison participants had similar results on most measures, with few exceptions. Discussion: When youths actively search for a job but do not find one, their motivation to continue job-seeking may be reduced, particularly if their preparedness to overcome job-seeking barriers is low. Although many participants had some engagement in volunteer or work activities, short-term work experiences were the most common—and perhaps most misunderstood—work activity. Implications for practitioners: Youths with visual impairments may benefit from feedback on their job-seeking approach, application materials, and interview skills so they can make changes and determine how to focus or refocus their efforts. In addition to offering feedback, service providers can provide ongoing support to youth job-seekers and encourage them to persist in their job search. Explicit discussions about different types of work activities may help transition-age youths understand how short-term work experiences differ from paid jobs.
Discrimination of Black and Muslim Minority Groups in Western Societies: Evidence From a Meta-Analysis of Field Experiments
Authors: Thijssen Lex , van Tubergen Frank , Coenders Marcel , Hellpap Robert , Jak Suzanne
Published: November 2021

This article examines discrimination against black and Muslim minority groups in 20 Western labor markets. We analyze the outcomes of 94 field experiments, conducted between 1973 and 2016 and representing ∼240,000 fictitious job applications. Using meta-analysis, we find that black minority groups are more strongly discriminated against than non-black minority groups. The degree of discrimination of black minority groups varies cross-nationally, whereas Muslim minority groups are equally discriminated across national contexts. Unexpectedly, discrimination against black minority groups in the United States is mostly lower than in European countries. These findings suggest that racial–ethnic discrimination in hiring can be better understood by taking a multigroup and cross-country perspective.
Neoadjuvant or adjuvant immunotherapy in bladder cancer: biological opportunity or clinical utility?
Authors: Petrelli Fausto , Perego Gianluca , Vavassori Ivano , Luciani Andrea
Published: November 2021

In urothelial cancer of the bladder, the introduction of immunotherapy with immune checkpoint inhibitors represents progress in the management of the disease’s early and advanced stages. In particular, recent studies have implemented these drugs in the neoadjuvant and adjuvant phases to treat muscle-invasive bladder cancer. In some studies, patients received neoadjuvant immune checkpoint inhibitors alone (PURE and ABACUS) to treat muscle invasive bladder cancer, whereas other studies provided this therapy to cisplatin-ineligible patients. Furthermore, a large Phase III study (CheckMate 247) compared placebo with adjuvant nivolumab therapy in patients with high-risk urothelial cancer after neoadjuvant chemotherapy and surgery or surgery alone. Despite some uncertain niches (nonbladder, PD-L1-negative tumors, and node-negative resected cancers), certain biological opportunities (exploring new targets, evaluating in vivo pathologic response, focusing on biomarkers for response) and clinical uses (avoiding chemotherapy at all or in frail patients, attaining similar pathologic complete response rates as in cisplatin-based chemotherapy) are valid reasons for incorporating these agents into the therapeutic armamentarium of medical uro-oncologists.
The Course of Psychiatric Symptoms During Remand Imprisonment
Authors: Bloem Oscar , Verkes Robbert-Jan , Bulten Erik
Published: November 2021

Imprisonment may pose a risk for unintended effects such as deterioration of psychiatric symptoms. Therefore, it is pivotal to understand the relation between imprisonment and the course of psychiatric symptoms, but previous studies are inconclusive. The current study followed up the psychiatric symptoms of newly admitted remand prisoners to one Dutch remand prison using the Brief Psychiatric Rating Scale (BPRS) and also studied possible related pre-existing variables. On average we found an overall slight—yet clinically marginal—improvement of psychiatric, in particular affective symptoms. One in three prisoners deteriorated and prisoners with psychotic disorders less often deteriorated. Other variables were not related. Overall, psychiatric symptoms remain stable over time during early remand imprisonment independent of most psychiatric disorders. The context in the Dutch prison studied appears to be adequately organized in terms of handling psychiatric stability, but we notice that prison contexts may vary to a large extend.
Does Religion Buffer Against the Detrimental Effect of Cyberbullying Victimization on Adults’ Health and Well-Being? Evidence from the 2014 Canadian General Social Survey
Authors: Chai Lei
Published: November 2021

While prior research has well-documented the detrimental effect of cyberbullying victimization on health and well-being among children and adolescents, less is known about whether the same adverse pattern can be observed among adults. Moreover, it is unclear about what psychosocial resources might moderate this association. The present study uses a nationally representative cross-sectional survey—2014 Canadian General Social Survey ( N = 17,548)—to examine three research questions. First, is cyberbullying victimization associated with adults’ self-rated health, mental health, and life satisfaction? Second, how does religiosity—religious service attendance and religious beliefs—moderate this association? Third, do any observed patterns further differ for men and women? Through a series of logistic and ordinary least squares regression models, the results show that adults who experienced cyberbullying victimization in the past 5 years are more likely to report poor self-rated health and mental health compared to those who did not experience cyberbullying victimization in the past 5 years. Likewise, cyberbullying victimization is also associated with lower levels of life satisfaction. In addition, the adverse associations of cyberbullying victimization in the past 5 years with self-rated health and life satisfaction are weaker among those who attended religious service at least once a week in the past twelve months. A similar pattern is observed for the buffering effect of viewing religious beliefs as very important in the adverse association of cyberbullying victimization in the past 5 years with self-rated life satisfaction. There is also evidence suggesting the gendered buffering effect of the importance of religious beliefs in the association between cyberbullying victimization and self-rated health. This study makes important empirical and theoretical contributions to the growing field of research on the association between cyberbullying victimization and health and well-being and to our understanding of how religion matters to individuals dealing with stressful experiences.
Childhood Community Risk Factors on Intimate Partner Violence Perpetration and Victimization Among College Students
Authors: Yeo Hyesu , Choi Y. Joon , Son Esther , Cho Hyunkag , Yun Sung Hyun , Lee Jungeun Olivia
Published: November 2021

The study examined the effect of community environments, such as community cohesion, community safety, and community poverty, in childhood on the likelihood of Intimate Partner Violence (IPV) perpetration and victimization in young adulthood. The study used the cross-sectional survey data of 2,082 college students collected in 2016–2017 from six universities in the U.S. and the data for the childhood community environment from the 2007–2011 American Community Survey. Hierarchical regressions were performed separately by gender to 1) assess the effects of community factors in addition to individual factors for IPV perpetration and victimization, and to 2) identify the interaction effect of community cohesion with community poverty on IPV perpetration and victimization. Community factors of community cohesion and community poverty were significantly correlated to different types of IPV. For IPV perpetration, only community cohesion was significant for, the interaction effect between community cohesion and poverty showed that higher community cohesion lowered the risk of community poverty on later IPV perpetration in both genders. For IPV victimization, only female students were affected by community poverty, whereas none of the community factors had an impact on male students. The findings imply the significance of early interventions and policies strengthening the community environment, especially community cohesion, for preventing IPV. The findings also suggest that assessing risk and protective factors on IPV in multiple contexts during childhood is important to develop effective programs preventing IPV.
Assessing the Victimizaton-Offending Hypothesis of Sexual and Non-Sexual Violence in a Nationally Representative Sample of Incarcerated Men in the United States: Implications for Trauma-Informed Practice in Correctional Settings
Authors: Marotta Phillip
Published: November 2021

Rates of exposure to sexual and non-sexual physical violence and other adverse childhood events are greater among people who are incarcerated with convictions for offenses related to sexual and non-sexual violence compared to other incarcerated populations and the general community. Few studies have differentiated which types of prior adverse experiences are greatest predictors of sexual and non-sexual violent offenses. The following study investigated associations between experiencing sexual abuse as a child or adult; experiencing non-sexual physical violence during childhood, adulthood, or both; having a caretaker who uses drugs; being in foster care; growing up in socioeconomically marginalized conditions; and the likelihood of reporting a prior physical or sexual conviction. The sample consisted of 13,604 men incarcerated in state and federal prisons in the United States. Multinomial regression models compared convictions for sexual offenses and non-sexual violent offenses to all other crimes. A model also compared sexual offenses to non-sexual violent offenses to differentiate between types of adverse childhood experiences associated with sexual versus non-sexual violent offending. Models adjusted for race/ethnicity, education, and age. Results suggest that exposure to violence during childhood was significantly and violence during adulthood was insignificantly associated with increased risk of conviction for a non-sexual physical offense. Sexual violence victimization as a child only was associated with increased risk of conviction for sexual violence perpetration during adulthood. Foster care involvement was associated with increased risk of being convicted for a non-sexual violent offense. Findings suggest that different traumatic pathways may differentiate types of aggression in adulthood. Future research must evaluate if trauma-informed approaches should be catered to address the unique effects of sexual and non-sexual victimization and the perpetration of different types of aggression in adulthood.
Parts of Me—Relational Risks and Possible Outcomes When Sharing the Decision to Have a Breast Augmentation: A Study of a Swedish Online Forum
Authors: Roll Bennet Petra
Published: November 2021

A female body part that gains much attention is breasts, and globally, the image of women’s breasts is a “perfect breast.” In order to attain this “perfection,” and for personal reasons, women can decide to augment their breasts by surgery. Despite the cosmetic industry’s increasing popularity, sharing this decision with family and friends can be associated with doubts and worries. This study aims to identify anticipated outcomes when telling close persons about the surgery. Analysis of posts on a Swedish online forum suggests that anticipated reactions include hopes of being accepted and fears of being viewed differently. Aligning with Cooleys “looking-glass self,” it is argued that women see themselves through the imagined eyes of others, and judgment creates feelings of either pride or shame. Breast augmentation seems to be associated with double oppression: first, from surrounding ideals about the perfect breast, and second, from associated shame manifested in social relationships.
How wealth matters for social policy
Authors: Marx Ive , Nolan Brian
Published: November 2021

This special issue looks at wealth in relation to social policy from a variety of perspectives. The articles all shed an innovative light on wealth in relation to a range of topics relevant for social policy researchers. This introduction provides an overview of the papers in this special issue and then highlights some of the gaps and shortcomings that remain. We conclude with some reflections on what this means for the future of social policy and research on it.
A novel concept of modular shape-adaptable sandwich panel with distributed actuation based on shape memory alloys
Authors: Testoni Oleg , Christen Sandro , Bodkhe Sampada , Bergamini Andrea , Ermanni Paolo
Published: November 2021

This work introduces a novel concept of modular, shape-adaptable sandwich panel with a distributed actuation system based on shape memory alloys (SMA). The panel consists of a modular arrangement of rigid cells connected with compliant active joints. Each joint hosts a SMA wire, which can be controlled independently, enabling the panel to achieve multiple shapes and complex curvatures with a single design. A numerical model of the actuators is developed combining the SMA model proposed by Brinson with a finite element model of the compliant joints, and validated against experimental results. Further, a demonstrator of the panel is manufactured and tested implementing four different actuation patterns and measuring the final shapes with a digital image correlation system. The results prove the capability of the proposed concept to achieve both in plane and out-of-plane deformations in the order of millimeters to centimeters, and to reproduce shapes with double curvatures. With the possibility to integrate sensors and additional components inside the core, the proposed shape-adaptable panel can be used to realize smart structures, which might be used for morphing aerodynamic surfaces or reconfigurable space structures.
Assessment of Cardiovascular Diseases Knowledge and Risk Factors Among Adult Population in the South Region of Saudi Arabia
Authors: Bdair Izzeddin A.
Published: November 2021

Cardiovascular diseases are the main cause of mortality and disability worldwide. This study aimed to assess knowledge of cardiovascular disease and risk factors among the adult population in the south region of Saudi Arabia. A web-based cross-sectional survey of 1,049 participants was completed during August 2021. Data were collected by using 25-item heart disease fact questionnaire. The study population included 526 men (50.1%) and 523 women (49.9%) with a mean age of 36 ± 12 years. The average total knowledge score was 65.7 ± 20.80. The items with the highest knowledge were smoking, overweight, aging, high cholesterol, hypertension, diabetes, and family history. Findings revealed that knowledge regarding cardiovascular diseases is inadequate with a high prevalence of risk factors among the Saudi Arabian population. Healthcare professionals and organizations have a crucial role in raising public awareness regarding health promotion, regular screening, and lifestyles modifications. Interventional studies are needed to investigate the actual magnitude of CVDs and counteract them.
On governing equations for a nanoplate derived from the 3D gradient theory of elasticity
Authors: Mikhasev Gennadi
Published: November 2021

The paper is concerned with the asymptotically consistent theory of nanoscale plates capturing the spatial nonlocal effects. The three-dimensional (3D) elasticity equations for a thin plate are used as the governing equations. In the general case, the plate is acted upon by dynamic body forces varying in the thickness direction, and by variable surface forces. The thickness of the plate is assumed to be greater than the characteristic micro/nanoscale measure and much smaller than the in-plane characteristic dimension (e.g., the wave or deformation length). The 3D constitutive equations of gradient elasticity are used to link the fields of nonlocal stresses and strains. Using the asymptotic approach, a sequence of relations for stresses and displacements in the form of polynomials in the transverse coordinate with coefficients depending on time and in-plane coordinates was obtained. The asymptotically consistent 2D differential equation governing vibration (or static deformation) of a plate accounting for both transverse shears and the spatial nonlocal contribution of the stress and strain fields was derived. It was revealed that capturing nonlocal effects in all directions leads to an increase in the correction factor compared with the well-known 2D theories based on kinematic hypotheses and the Eringen-type gradient constitutive equations. The effect of the internal length scales parameters on free low-frequency vibrations and displacements of a plate is discoursed.
Valuing the Impact of Air Pollution in Urban Residence Using Hedonic Pricing and Geospatial Analysis, Evidence From Quito, Ecuador
Authors: Borja-Urbano Sebastian , Rodríguez-Espinosa Fabián , Luna-Ludeña Marco , Toulkeridis Theofilos
Published: November 2021

Air pollution is one of the hazardous effects of urbanization. Hereby, one the most polluted cities in Ecuador is the Metropolitan District of Quito (DMQ). This study attempts to determine the marginal willingness to pay for a cleaner air in the DMQ using the impact of air pollutants on price properties. Spatial interpolation techniques visualized pollutant concentrations in the DMQ. Additionally, a hedonic price model estimated air pollution impact on properties. Results demonstrated hazard levels for at least three pollutants, being Particulate Matter PM2.5, Nitrogen Dioxide NO2, and Sulfur Dioxide SO2. Subsequently, the economic impact on the house market was statistically significant with a decrease in property value between 1.1% and 2.8%. These drop of value between 1,846.20 up to 4,984.74 US$ (United States Dollars) represents a substantial loss in property value for the DMQ and loss of revenues for the city.
High-performance connections: Digital holism and communicative capitalism at HappyAppy
Authors: Islam Gazi , Pillet Jean-Charles , Navazhylava Kseniya , Barros Marcos
Published: November 2021

The current study examines the ways in which new age organizations use digital culture to promote “holistic” visions of personal and social well-being. Concepts of holism are common in contemporary and new age management settings, but are largely undertheorized by organizational scholars; moreover, the relations between holism and techno-culture, increasingly recognized by digital sociologists, are largely missing from organizational scholarship. Using the lens of “communicative capitalism,” we carry out a case study of “HappyAppy,” a French techno-startup association concerned with well-being related applications, to understand how holistic ideas are deployed and shaped within this association. We find that that holism is marked, on the one hand, by “autarkic” fantasies, involving subjective integration and immersion, and on the other, by “relational” fantasies, involving interpersonal connection and participation. Moreover, each of these versions of holism is associated with distinct critical possibilities. We use these results to theorize the role of digital holism at the intersection of new age management and digital culture, outlining an agenda for future research.
An approach to investigating rolling element bearing damage under impact loading
Authors: Savolainen Matti , Lehtovaara Arto
Published: November 2021

This paper presents an approach to studying rolling element bearing damage under the interference of impact loading. In the experimental part, a series of bearing tests was performed by using the twin-disc test device with artificially damaged bearings. This was followed by analysis of the measured acceleration response data in impact-free condition as well as under the influence of the impact loading. The results showed successful detection of the bearing outer race damage by using typical bearing damage detection approaches regardless whether the impact loading was applied to the system or not. In turn, recognition of the bearing rolling element damage required specific signal processing.
Mediating American hospitality: Mark Zuckerberg’s challenge to Donald Trump?
Authors: Winch Alison , Little Ben
Published: November 2021

In 2017, Facebook founder and CEO, Mark Zuckerberg, travelled America with a former White House photographer who took pictures of him sharing meals with families, workforces and refugee communities. These were then posted to Zuckerberg’s Facebook page, usually with a post by Zuckerberg drawing attention to socioeconomic issues affecting different American communities. This article argues that Zuckerberg is mediated on this tour as a worthy populist contender to Donald Trump, albeit of a centrist, liberal, corporate kind. In particular, divisions along the lines of race, migration and class, which have been appropriated and emphasised by Trump, are apparently bridged and resolved through the representation of Zuckerberg, and the promotion of Facebook as a mediated fulcrum for civil society. Zuckerberg is pictured sharing food with, for example, Republican voters in Ohio and Somali migrants in Minnesota. We investigate how the differences projected between Zuckerberg and Trump pivot on the commodification of hospitality, particularly the mediation of shared meals, American hospitality, masculinity and ‘diversity work’. We contextualise this analysis within an understanding of how Silicon Valley’s monopoly capitalism perpetuates inequalities in its workforces and through its product design. We also attempt to make sense of the different social actors involved in Zuckerberg’s mediated ‘Year of Travel’, including the PR team, the people in the photographs, the commenters, as well as the users of Facebook. Through these contextualisations, we argue that this mediated contestation of hospitality – who is welcome in American society, who is not and why – is central to understanding the tensions in contemporary American political culture.
Effect of the ramp injection rate shape on the performance and emissions of a natural gas/diesel dual fuel engine
Authors: Yazdani Motlagh Tara , Azadani Leila N
Published: November 2021

Injection rate shape has a great influence on the spray evolution, and consequently on the performance and emission characteristics of compression ignition engines. In this study, effect of different ramp injection rate shapes on the performance and exhaust emissions of a natural gas/diesel reactivity controlled compression ignition (RCCI) engine was investigated. 64 numerical experiments were performed to study effect of two characteristic parameters of the ramp injection rate shape, including ramp duration and ramp injection rate on the engine gross indicated efficiency (GIE) and emissions formation. It was realized that for a constant value of the ramp duration, the engine gross indicated efficiency and [Formula: see text] emissions are lower, and CO and unburned hydrocarbons (UHC) emissions are higher for medium values of the ramp injection rate. Moreover, for a constant value of the ramp injection rate, the engine gross indicated efficiency and [Formula: see text] emissions are higher, and CO and unburned hydrocarbons emissions are lower for medium values of the ramp duration. The optimum values of the ramp duration and ramp injection rate were determined and it was revealed that the optimum ramp injection rate shape can improve the engine gross indicated efficiency by 54.78%.
Discovery of metabolomic biomarkers for discriminating platinum-sensitive and platinum-resistant ovarian cancer by using GC-MS
Authors: Eroglu Evren C. , Tunug Sule , Geckil Omer Faruk , Gulec Umran Kucukgoz , Vardar Mehmet Ali , Paydas Semra
Published: November 2021

This study aims to determine ovarian cancer (OC) patients with platinum resistance for alternative treatment protocols by using metabolomic methodologies. Urine and serum samples of platinum-resistant and platinum-sensitive OC were analyzed using GC-MS. After data processing of GC-MS raw data, multivariate analyses were performed to interpret complex data for biologically meaningful information and to identify the biomarkers that cause differences between two groups. The biomarkers were verified after univariate, multivariate, and ROC analysis. Finally, metabolomic pathways related to group separations were specified. The results of biomarker analysis showed that 3,4-dihydroxyphenylacetic acid, 4-hydroxybutyric acid, L-threonine, D- mannose, and sorbitol metabolites were potential biomarkers in urine samples. In serum samples, L-arginine, linoleic acid, L-glutamine, and hypoxanthine were identified as important biomarkers. R2Y, Q2, AUC, sensitivity and specificity values of platinum-resistant and sensitive OC patients’ urine and serum samples were 0.85, 0.545, 0.844, 91.30%, 81.08 and 0.570, 0.206, 0.743, 77.78%, 74.28%, respectively. In metabolic pathway analysis of urine samples, tyrosine metabolism and fructose and mannose metabolism were found to be statistically significant (p < 0.05) for the discrimination of the two groups. While 3,4-dihydroxyphenylacetic acid, L-tyrosine, and fumaric acid metabolites were effective in tyrosine metabolism. D-sorbitol and D-mannose metabolites were significantly important in fructose and mannose metabolism. However, seven metabolomic pathways were significant (p < 0.05) in serum samples. In terms of p-value, L-glutamine in the nitrogen metabolic pathway from the first three pathways; L-glutamine and pyroglutamic acid metabolites in D-glutamine and D-glutamate metabolism. In the arginine and proline metabolic pathway, L-arginine, L-proline, and L-ornithine metabolites differed significantly between the two groups.