bluuebunny/crossref_metadata_2025 huggingface dataset:
Case of transitional meningioma in a dog
Authors: JAGIEŁA ANNA , ŚMIECH ANNA , LACHOWICZ KATARZYNA , KOMSTA RENATA , JAROSZ BOŻENA , BANACH AGATA , STANIEC MARTA , TWARDOWSKI PIOTR
Published: April 2024

Meningiomas are the most common intracranial primary brain tumours in dogs and cats. Neurological symptoms vary depending on the location of the meningioma in the brain. In dogs, the most common clinical symptom are seizures. Other symptoms include ataxia, blindness and behavioural changes. In the case of suspected brain cancer, the most reliable additional examinations are magnetic resonance imaging and computed tomography. They allow us in visualising the tumour itself and in evaluating the structures adjacent to the tumour. It has a considerable impact on the prognosis and enables planning of surgical laccess. A 10-year-old Belgian Shepherd was presented with strongly expressed neurological symptoms. CT examination revealed a heterogenous, hyperdense, oval focallesion with ill-definede dges and the following dimensions. The lesion was adjacent to the presphenoid bones, within the olfactory bulbs in the forebrain. After a CT scan of the brain, due to a clearly bad prognosis, the owner decided not to wake the animal up from anaesthesia and to euthanize it. During the autopsy of the animal, brain tumour fragments were collected for histopathological examination. Based on the histological features and presence of two types of cells that form the tumour structure, the observed mass was classified as a transitional (mixed) meningioma.
CHALLENGES OF DETERMINING THE RESIDENCE OF A CHILD IN CONDITIONS OF MARTIAL LAW IN UKRAINE
Authors: Hubanova Olha V. , Noha Petro P.
Published: April 2024

The article is devoted to the study of the problems of determining the place of residence of a child during martial law in Ukraine. It is determined that cases regarding the determination of the child's place of residence are quite complex (due to the subject composition, sphere of relations, etc.), but under martial law they are further complicated by the impossibility of enforcement of court decisions, the lack of effective control over compliance with such execution and the objective limitation of judicial discretion in terms of making the final decision. Attention is focused on the positions of the Supreme Court in cases regarding the determination of the child's place of residence. The article assesses the mediatoriness of cases regarding the problems of determining the child's place of residence during martial law in Ukraine. The authors came to the conclusion that in cases of determining the child's place of residence during martial law in Ukraine, the only effective way to seek consensus and implement agreements between the parties or a court decision is the mediation procedure as an alternative way to resolve the conflict. In resolving a family law dispute, mediation is quite effective, since it not only contributes to the resolution of a legal dispute between the parties, but also directly affects the family conflict as a prerequisite for its occurrence. When conducting mediation in determining the child's place of residence, it is important to take into account two factors: 1) taking into account the child's opinion when deciding on all issues concerning him/her; 2) the legal possibility for a child to conclude two types of transactions – a mediation agreement and an agreement based on the results of mediation. It is concluded that it is possible to conclude a mediation agreement and an agreement based on the results of mediation by a person who has reached the age of 14, but with the consent of the child's parents (adoptive parents) and his/her legal representatives, the minor child does not have the necessary amount of civil capacity to conclude transactions in the field of mediation, and therefore his/her participation in the procedure as a party to mediation is excluded. The issue of mediation with persons with manifestations of PTSD is considered. It is proposed to strengthen and expand the possibilities of consular registration to establish the actual stay of one of the parents with the child abroad. The need to use online means of video communication for the participation of the parent who does not live with the child and is abroad in the upbringing of the latter is emphasized.
THE REPRESENTATIVE DEMOCRACY IDEAS EVOLUTION IN THE CONTEXT OF DECISION-MAKING BY THE HIGHER COLLEGIATE BODIES OF STATE POWER
Authors: Liubchenko Oleksii O.
Published: April 2024

The work is devoted to the study of representative democracy ideas in the context of decision-making by higher collegiate bodies of state power of Ukraine. The author emphasized that the most optimal is the use of the term democracy in the understanding of the form of government and political regime in the context of the analysis of the decision-making procedure by the higher collegiate bodies of the state power of Ukraine.Attention is drawn to the diversity of point`s of view in the literature on the continuity of the development of the democratic tradition in Western culture, including the emergence of the elitist theories of democracy in XX century. The connection between the decisions of representative institutions of power and the will of the people is considered. Particular attention has been paid to the growing role of constitutional jurisdiction bodies in decision-making that mitigates the shortcomings of electoral-representative democracy.The author found out that participatory democracy in modern democracies in no way undermines the principles of representative government, but quite harmoniously complements it. It is indicated that the idea of involving in exceptional cases from the most important issues of the maximum possible number of citizens in the decision-making process, guaranteeing in other cases the opportunity to participate in decision-making to all willing citizens, the most justified.The author concluded that there is no viable alternative to representative democracy and participatory democracy, considering the amount of values they provide, their meaning and weight in domestic constitutional practice, has further developed.
ADMINISTRATIVE SERVICES DURING THE STATE OF MARTIAL
Authors: Tykhonova Daria S.
Published: April 2024

The article examines the concept of centers for the provision of administrative services. The procedure for ensuring proper availability of administrative services and the formation of a network of centers for the provision of administrative services by creating territorial units and remote (including mobile) workplaces of administrators of centers for the provision of administrative services in settlements of territorial communities has been determined.It was noted that thanks to the effective reform of the decentralization of local self-government bodies and the granting of new powers, the Centers for the provision of administrative services, which previously functioned in district centers and large cities, began to appear in village and village councils, and the number of services provided by them increased.Attention was drawn to the fact that the main problems in the field of administrative services are the dependence of administrators of administrative service centers on state and local registers, as a result of which the most popular administrative services were not provided at the beginning of the full-scale invasion of the Russian Federation on the territory of Ukraine, namely: registration of place of residence, registration and Issuance of passport documents, affixing of photo cards to the passport of a citizen of Ukraine (model of 1994) when the citizen reaches the age of 25 and 45, registration of legal entities and sole proprietorships, registration of real estate, registration of driver's licenses and registration of vehicles, issuance of information from the State Land Cadastre. 
At the same time, it should be noted that the Government quickly adopted changes to the normative legal acts that regulate the procedure for providing administrative services under martial law, namely: the introduction of the principle of extraterritoriality by entities providing administrative services, the reduction of the number of necessary documents for obtaining administrative services, the period of validity of identity documents (international passport of a citizen of Ukraine) has been extended for 5 years, a passport of a citizen of Ukraine without a timely pasted photo card and a driver's license, the validity of which expired during the martial law - remain valid, payments of social assistance from the state continue and are paid for a full moon without a human address.
Carbamates: Are they "Good" or "Bad Guys"?
Authors: Voris Diego , Cavalcante Samir , Borges Caio , Lima Antonio
Published: April 2024

In this short review, we address carbamates, a class of chemical compounds derived from carbamic acid, which have garnered attention as both valuable assets and potential hazards across diverse applications. Their stable structure, characterized by the R-O-CONH-R functional group, allows for various substituents, enabling their use in medicine, agriculture, and even as chemical warfare agents. In medicine, carbamates play a significant role as components of numerous medications approved by Food and Drug Administration. The stability and permeability properties of carbamates have led to the enhancement of various pharmacological compounds, aiding drug development. In agriculture, carbamates have been used as pesticides to manage pests and increase crop productivity. Despite their effectiveness, overuse and inadequate regulation have raised concerns about environmental contamination and health risks. In this review, we also seize the opportunity to present information to the readers about the framework of international agreements on toxic compounds, highlighting their potential misuse as chemical warfare agents and how they have been a reason of concern, with their high toxicity across various exposure pathways. The inclusion of certain carbamates in the Chemical Weapons Convention underscores their lethal nature. However, they lack comprehensive research, raising questions about their complete effects and potential countermeasures.
Integrated Risk Management System in Food Production: Theory and Model
Authors: Voloshina Elena , Dunchenko Nina
Published: April 2024

Every enterprise in the food and food-processing industry needs a risk-based approach that could help it operate in the current conditions of constant changes and uncertainty. As management and technological risk approaches tend to integrate, risk management technologies have to be adapted to enterprise processes in order to minimize hazardous factors in food production. This article introduces a model of an integrated risk management system for raw materials and animal products. The model covers both risk management methods of food production and risk management tools. The authors defined nine principles for developing quality and safety indicators in the sphere of producing foods of animal origin. The program for assessing a risk event facilitates decision-making when it comes to reducing human factor risks. Other tools include a three-dimensional risk assessment matrix, as well as profiles and risk registers for rapid data processing during decision-making. The aggregate system makes it possible to minimize the negative consequences for all risk groups, as well as to use the positive results of risk events to fuel further industrial development.
Prospects for Fortifying Preserved Dairy Products with Iodized Whey Proteins
Authors: Barkovskaya Irina
Published: April 2024

Iodine is an essential trace element involved in the synthesis of thyroid hormones. Its deficiency may trigger pathologies of various kinds in all age groups. Over the last 20 years, two billion people in the world have been diagnosed with iodine deficiency. In Russia, this number is 14 million. In 1994, the World Health Organization introduced several salt iodization programs, and the global level of iodine deficiency and related diseases went down. However, some countries still experience social inequality in iodized salt intake. Moreover, inorganic forms of iodine get unstable during transportation and cooking. As a result, iodized salt cannot be considered a universal method. This article features new approaches to iodine deficiency prevention, e.g., high-iodine diets. The research objective was to analyze the market of iodized dairy foods, including canned dairy products. The review featured the existing technologies of fortifying whole-milk products and canned or otherwise preserved dairy foods with iodine. Such products have some disadvantages. For instance, production of organic iodine preparations is time-consuming, and the resulting products often lack trace elements that facilitate iodine metabolism, e.g., zinc. In this connection, the functional food industry needs new food additives to iodize dairy products. Partially hydrolyzed whey proteins seem a promising raw material for iodine and zinc immobilization.
Construction of water resource allocation model based on green supply chain theory
Authors: Lan Ying
Published: April 2024

With global environmental change and population growth, the problem of water resources management is becoming increasingly prominent. Based on the theory of green supply chain, this paper discusses the effective management and allocation strategy of water resources. Through detailed data acquisition and preprocessing, the accuracy and reliability of the study are ensured. Then, a comprehensive water resource allocation model is designed and implemented. Through many experiments and verification, the model shows good stability and accuracy. This study not only provides a new perspective and method for theoretical research but also provides a valuable reference for practical water resources management. However, there are also some limitations, which provide further thinking and expansion space for future research.
Establishing a river health evaluation index system for seven rivers in Jiamusi City of China
Authors: Shao Weiwei , Han Guang , Li Jiaqi , Yang Zhiyong , Liu Jiahong , Xu Tianyin
Published: April 2024

The Jiamusi section of the Songhua River is one of the first 17 model river construction sections in China. The implementation of river health assessments can determine the health dynamics of rivers and test the management's effectiveness. Targeting seven rivers, this study conducted river zoning and monitoring point deployment to conduct sufficient field research and monitoring. The authors selected hydrological and water resources, physical structure, water quality, aquatic life, social service functions, and management as guideline layers and 15 indicator layers. Subsequently, the authors established an evaluation index system to evaluate and analyze the ecological status and social service status of each river. The results showed that the Yindamu, Alingda, and Gejie rivers scored well as healthy rivers, with health evaluation scores of 78.98, 76.06, and 75.83, respectively. The Wangsanwu, Lujiagang, and Lingdangmai rivers are generally sub-healthy rivers with scores of 71.55, 67.97, and 60.7, respectively. The Yinggetu River has a score of 54.52 and is therefore assessed as unhealthy. Based on the scientific evaluation index method, this study analyses the current river health state in Jiamusi City to provide the basis for the evaluation of the river chief's work and future river management.
Schiff Bases: A Captivating Scaffold with Potential Anticonvulsant Activity
Authors: Sahu Rakesh , Shah Kamal
Published: April 2024

One of the most important organic compounds, also known as a Schiff base, imine, or
azomethine, has been associated with several biological processes. The group is a component of
both natural or synthetic chemicals and functions as both a precursor and an intermediary in the synthesis
of therapeutically active substances. The review highlights the various non-metal Schiff bases'
structure-activity relationship (SAR) studies, general model, docking, and design approach for anticonvulsant
actions. Schiff bases serve as linkers in numerous synthetic compounds with a variety of
activities, according to the findings of several investigations. As a result, the current review will
give readers a thorough understanding of the key ideas put forth by different researchers regarding
the anticonvulsant properties of Schiff bases. It will serve as a valuable information source for those
planning to synthesize new anticonvulsant molecules that contain Schiff bases as pharmacophores
or biologically active moieties.
The HGF/Met Receptor Mediates Cytotoxic Effect of Bacterial Cyclodipeptides in Human Cervical Cancer Cells
Authors: Hernandez-Padilla Laura , Duran-Maldonado Mayra X. , Martinez-Alcantar Lorena , Rodriguez-Zavala Jose S. , Campos-Garcia Jesus
Published: April 2024

Background:

Human cervix adenocarcinoma (CC) caused by papillomavirus is the
third most common cancer among female malignant tumors. Bioactive compounds such as cyclodipeptides
(CDPs) possess cytotoxic effects in human cervical cancer HeLa cells mainly by
blocking the PI3K/Akt/mTOR pathway and subsequently inducing gene expression by countless
transcription regulators. However, the upstream elements of signaling pathways have not been
well studied.

Methods:

To elucidate the cytotoxic and antiproliferative responses of the HeLa cell line to CDPs
by a transcriptomic analysis previously carried out, we identified by immunochemical analyses,
differential expression of genes related to the hepatocyte growth factor/mesenchymal-epithelial
transition factor (HGF/MET) receptors. Furthermore, molecular docking was carried out to evaluate
the interactions of CDPs with the EGF and MET substrate binding sites.

Results:

Immunochemical and molecular docking analyses suggest that the HGF/MET receptor
participation in CDPs cytotoxic effect was independent of the protein expression levels. However,
protein modulation of downstream Met-targets occurred due to the inhibition of phosphorylation
of the HGF/MET receptor. Results suggest that the antiproliferative and cytotoxicity of CDPs in
HeLa cells involve the HGF/MET receptor upstream of PI3K/Akt/mTOR pathway; assays with
the human breast cancer MCF-7 and MDA-MB-231cell lines supported the finding.

Conclusion:

Data provide new insights into the molecular mechanisms involved in CDPs cytotoxicity
and antiproliferative effects, suggesting that the signal transduction mechanism may be related
to the inhibition of the phosphorylation of the EGF/MET receptor at the level of substrate
binding site by an inhibition mechanism similar to that of Gefitinib and foretinib anti-neoplastic
drugs.
Effects of Vitamin D and E Supplementation on Prevention of Bronchopulmonary Dysplasia (BPD) in Premature Neonates: A Systematic Review and Meta-Analysis
Authors: Farahbakhsh Nazanin , Sharma Deepak , Fatahi Somaye , Fathi Mobina , Vakili Kimia , Deravi Niloofar , Tutunchian Zohreh , Ahsan Elahe , Yaghoobpoor Shirin , Tabatabaii Seyed Ahmad
Published: April 2024

Background:

Bronchopulmonary Dysplasia (BPD) has a multifactorial etiology. Vitamin
E and vitamin D play an important role in lung development and can potentially be beneficial
in the prevention of BPD.

Objective:

The study aimed to compare the risk of BPD occurrence in preterm neonates supplemented
with vitamin D or E versus those who did not get supplementation.

Methods:

The literature search was conducted for this systematic review by searching the
PubMed, Scopus, and Web of Science databases up to December 2022. Randomized controlled
trials involved administering vitamin D or E to preterm neonates and examining the occurrence of
BPD. We excluded non-English articles, and articles with non-relevant and insufficient data. We
used the Critical Appraisal Skills Programme (CASP) checklist to assess the quality of the included
studies. We used Egger’s test to evaluate the risk of bias among the included studies. Heterogeneity
was also assessed through Q-test and I2. We applied the random effect model for analysis.
A P-value less than 0.05 was considered as significant. All the statistical analysis in the current
study was performed using STATA 14. The Relative Risk (RR) was calculated as the effect size
with 95% Confidence Interval (CI).

Results:

Three eligible studies seeking the role of vitamin D in the prevention of BPD were analysed.
Meta-analysis revealed that receiving vitamin D supplementation can significantly reduce
the risk of BPD in preterm infants (RR = 0.357, 95% CI: 0.189-0.675, I2 = 0.0%; p = 0.002). Similarly,
for assessing the role of Vitamin E in the prevention of BPD, three eligible studies were analysed.
Vitamin E supplementation was not found to play a significant role in the reduction of BPD
(RR = 0.659, 95%CI = 0.243-1.786, I2 = 38.7%; p = 0.412).

Conclusion:

Vitamin D supplementation could be beneficial in preventing BPD in preterm infants.
However, evidence is not enough regarding vitamin E's role in reducing the incidence of
BPD in preterm infants.
Apnea of Prematurity as Manifestation of Immature Control of Breathing: A Mini-Review
Authors: Simone Foti Randazzese , Fabio Toscano , Federico Motta , Serena Costantino , Michela Leotta , Federica D’Amico , Federica Xerra , Giulia Cafarella , Maria Patané Eleonora
Published: April 2024

:

Apnea of prematurity is a common developmental defect affecting newborns, linked to
the immaturity of systems involved in controlling breathing, particularly, central and peripheral
chemoreceptors. Its severity, as well as its clinical manifestations, is inversely associated with gestational
age. Symptoms of immature control of breathing progressively improve with age, with a
resolution around 34-36 weeks of gestational age or 40-44 weeks in infants born at younger gestations.
Prevalence seems to be higher in females and same-gender twins. The role of genetics was
investigated: polymorphisms in genes encoding for adenosine receptors were associated with a
higher risk of developing apnea of prematurity and bronchopulmonary dysplasia. Continuous monitoring
of breathing patterns and vital signs is essential for the early detection of apnea episodes,
while respiratory polygraphy shows limited utility. It is essential to treat newborns with apnea or
other clinical manifestations of immature control of breathing to prevent the risk for long-term
morbidities, such as bronchopulmonary dysplasia or neurodevelopmental impairment. There is no
international consensus on the management of these premature infants. Nowadays, caffeine represents
the first line of pharmacological treatment in association with noninvasive ventilatory support
techniques. Furthermore, in the USA, doxapram is used in the case of refractory therapy with
caffeine. Among nonpharmacological strategies, transfusion, prone positioning, tactile and olfactory
stimulation, and kangaroo care were widely studied, but their efficacy is still unclear.
Omentin 1: A Promising Regulator and Therapeutic Target in the Battle against Obesity, Diabetes, and Alzheimer’s Disease
Authors: Kumar Kushawaha Shiv , Sharma Radhika , Singh Ashawat Mahendra
Published: April 2024

Mechanistic investigations in both animal models and human subjects have consistently elucidated a causal relationship between obesity, diabetes, and Alzheimer's disease (AD). Alzheimer's disease is the predominant etiology of dementia, marked by progressive cerebral degeneration char-acterized by the formation of intracellular neurofibrillary tangles and extracellular amyloid beta (Aβ) plaques. Adipose tissue secretes bioactive signaling molecules known as adipokines. Interactions be-tween adipose tissue and the central nervous system serve as the foundational mechanism contrib-uting to the elevated susceptibility of individuals with obesity to the onset of neurologic disorders, including cognitive and mood-related disturbances. Omentin is a recently discovered adipokine that has gained attention for study because of its pleiotropic effects on several disorders. The specific receptor responsible for binding with Omentin remains unidentified thus far. This investigation elu-cidates the variability in Omentin levels observed in multiple pathological conditions. Therapeutic methods to raise omentin-1 levels may be helpful for the treatment or prevention of several illnesses. Increases in circulating omentin-1 levels can be achieved with weight loss, an olive oil-rich diet, aerobic exercise, atorvastatin therapy, and the use of diabetes medications. It is also possible to use circulating omentin-1 as a biomarker of obesity, diabetes, metabolic syndrome, atherosclerosis, is-chemic heart disease, inflammatory disease, cancer, and neurological diseases via AMP-activated protein kinase/Akt/nuclear factor-κB/mitogen-activated protein kinase (ERK, JNK, and p38) signal-ing. This review provides insights into the potential use of omentin-1 as a biomarker for Obesity, Diabetes, and associated metabolic and neurological disorders.
Unlocking the Potential of Induced Pluripotent Stem Cells in
Revolutionizing Cancer Therapy
Authors: Mondal Amrita , Talukdar Ankita , Haque Rizwanul
Published: April 2024

Induced Pluripotent Stem Cells (iPSCs) are among the top versatile implements of
biomedical research. Stem cell science has made strides over the past few years, emerging as a
new opportunity to treat cancer, and many such continuous initiatives have been made into clinical
trials. As the global mortality rate is too high despite the effectiveness of prevalent cancer therapies,
this review explores the potential of iPSC in different aspects of cancer-related areas. The
preparation of iPSCs, including their derivation from cancer stem cells, was covered after establishing
the intricacy of current cancer treatments. This article highlights the potential of iPSC-
based NK cells and dendritic cells for immunotherapy and delves into the role of iPSC-based
mesenchymal cells in targeted therapy. The potential of iPSC-derived organoids as a vital tool for
disease modeling and drug discovery has been showcased, and the importance of iPSC-based cancer
vaccines is also emphasized. The ongoing clinical trials of iPSC-based cancer treatment have
also been highlighted. Though much work remains to be done to implicate these iPSC-based therapeutic
options from research labs to clinics and hospitals, ongoing studies and clinical/translational
follow-ups raise hope for novel cancer therapies employing iPSC technology.
Stability Indicating Method Development and Validation for the
Estimation of Bempedoic Acid by RP-HPLC
Authors: Chaudhari Mansi V. , Chaudhari Ujwal , Sahu Jagdish K. , Bagade Shashikant B.
Published: April 2024

Background:

Bempedoic acid (BEM) belongs to a category of drugs known as Adenosine triphosphate-citrate Lyase (ACL) inhibitors. It is a prodrug with intracellular activation that is administered orally. Bempedoic acid is used to treat existing atherosclerotic cardiovascular diseases, mainly hypercholesterolemia.

Methods:

For the stability-indicating assay, the HPLC method was employed using a Kromasil 100-5-C8 column (100 mm × 4.6 mm), a UV detector set at 230 nm, and a mobile phase comprising a 70:30 v/v mixture of acetonitrile and 0.1% Orthophosphoric Acid (OPA) buffer. The method was operated at an ambient temperature with a flow rate of 1 mL/min. The method developed has been statistically validated according to ICH guidelines.

Results:

The stability-indicating method was executed using a Kromasil 100-5-C8 (100 mm × 4.6 mm) column at a 1.0 mL/min flow rate. A mixture of acetonitrile and 0.1% Ortho-phosphoric Acid (OPA) buffer in a 70:30 v/v ratio made up the mobile phase. BEM's retention times were discovered to be 1.88 minutes each. The temperature was kept at room temperature. 234 nm was the ideal wavelength for BEM. According to ICH criteria, the approach developed has undergone statistical validation. BEM's % RSD was discovered to be 0.6, respectively. For BEM, the % recovery was determined to be 100.0%. Regression models for bempedoic acid yielded LoD and LoQ values of 3.3 and 10.1 g/mL, respectively. The method showed good reproducibility and recovery with a % RSD less than 2. Studies on forced degradation confirmed the method's capacity to indicate stability in the presence of stress conditions, such as acid, basic, peroxide, UV, heat, and humidity. Both the retention times and the run time were shortened.

Conclusion:

In accordance with ICH Q2 (R1) guidelines, this method was successfully test-ed with HPLC to confirm the chemical structures of newly produced degradation products of bempedoic acid.
Rapid, Simple and Low-Cost Analytical Method Development for
Quantification of Eltrombopag Olamine in Tablet Dosage by UV
Spectroscopy Method
Authors: Godani Nandan , Sharma Sanjay
Published: April 2024

Background:

Eltrombopag Olamine is a drug used to treat thrombocytopenia, a dis-order where blood platelet counts get lower and severe aplastic anemia. It serves as a thrombo-poietin receptor agonist, which give rise to platelet production in the bone marrow.

Objectives:

The objective of this study is to develop a simple, specific, accurate, precise and economical Ultraviolet spectroscopy method to estimate the amount of Eltrombopag Olamine in bulk and tablet dosage form.

Methods:

The developed method was performed using methanol for identification and physico-chemical characterization of the drug. The validation parameters like linearity, precision, accuracy, robustness limits of detection and quantitation, and specificity were assessed as per ICH Q2 (R2).

Results:

The maximum absorbance wavelength (λmax) of the drug was found at 247 nm in methanol. The linearity was found in the concentration range of 2-14 μg/ml with regression equation y = 0.0619x - 0.0123 and r² = 0.999. The standard addition method was used to deter-mine the accuracy of the developed method. The result was found in the % recovery range of 98-99%. The precision was done on λmax with respect to the parameters such as repeatability, intraday, and interday. The method was found to be precise as the % RSD value was found to be <2%. The detection limit value (LOD) and quantitation limit value (LOQ) were 0.0524 μg/ml and 0.1588 μg/ml, respectively.

Conclusion:

The developed method is simple, economical, accurate and selective. The developed method was adaptable for the estimation of Eltrombopag Olamine analysis in pharmaceutical dosage form and routine quality control laboratory.
Metal-free Oxidations with m-CPBA: An Octennial Update
Authors: Varala Ravi , Seema Vittal , Hussein Mohamed , Ismail Mostafa A. , Alam Mohammed Mujahid
Published: April 2024

meta-Chloroperbenzoic acid (mCPBA) is a readily available peroxide that is a powerful
oxidizing agent utilized in a range of oxidative reactions. Metal-free oxidations mediated by
mCPBA involving selective oxidation of aliphatic amines to oximes, selective oxidation of organosulphides/
aldehydes, synthesis of heterocyclic N-oxides, domino C[sp2] hydroxylation/
annulation of enaminones (heterocyclic ring formation), acid to phenol conversion, oxidation
of exocyclic C=C bond, oxidative ring contraction, etc. have been comprehensively and critically
examined in this review from 2015 to date.
WITHDRAWN: A Numerical Study on Performance Optimization of Household Solar-air Source Heat Pump System in Hot Summer and Cold Winter Regions of China
Authors: Zhao Jiayue
Published: April 2024

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn from the journal Recent Patents on Mechanical Engineering.
Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.
The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.
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the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
A Systematic Literature Review on the Working Dilemma of Petrochemical Offshore Workers: A gender perspective
Authors: Kamarunzaman Nur Zafifa , Ahmad Zawawi Azlyn , Yaacob Nur Ain , Liu Jia
Published: April 2024

This paper aims to identify the dilemma offshore petrochemical workers face using a gender lens. The gender lens allows examining how gender identities, norms, and power dynamics shape experiences, opportunities, and outcomes for different groups of people. Two databases were used in this search, namely the Web of Science and Scopus. The results indicated that 11 articles were accepted after the identification, screening and eligibility processes were undertaken. Based on the thematic analysis, four emerging themes include psychosocial risks, gender stigma, benefits, and social capital. The findings have practical contributions.
WEEE Behaviour from Households: A qualitative approach
Authors: Md Radzi Nor Etiqah , A-Jalil Emy Ezura , Mahmod Musyrifah , Awang Salleh Erni Salleh
Published: April 2024

E-waste disposal practices associated with the problem of environmental sustainability have emerged as one of the discussion's most intriguing subtopics. Adopting efficient e-waste management systems is essential to successfully reusing, recycling, and value recovery activities. Only 20% (8.9 Mt) of the e-waste produced in 2016 was collected correctly and recycled. It highlights the shortcomings of e-waste management systems, which are crucial for home electronic disposals, especially in Malaysia. It is critical to consider how vital waste management systems are to enhancing the environment's performance and the nation's economy. Collaboration is critical to the overall performance of e-waste management among all parties involved in the logistics chain, including customers (households) and governmental and commercial entities. Using a qualitative approach to understanding the different narratives among stakeholders juxtaposing the crucial element to sustain WEEE from landfills.
Fake News and Covid-19: Malaysian legal perspective
Authors: Mohamed Kamil Ida Shafinaz , A. Malek Mohd Dahlan
Published: April 2024

The outbreak of the COVID-19 pandemic has been accompanied by fake news which is as dangerous as the virus itself. Many countries have promulgated laws to combat fake news including Malaysia. This paper considered the criteria for fake news offences and the regulatory measures and non-regulatory measures put in place to counter fake news in Malaysia. Employing a doctrinal methodology, this article analyses the relevant legislations and case laws for offences and punishments with regards to fake news Based on the findings, the paper proposes an amendment in the relevant laws to combat fake news in Malaysia.
Ombudsman in Malaysia: Ombudsman in Sarawak and Ombudsman for Financial Services (OFS) in Kuala Lumpur
Authors: Zulkarnain Izyan Farhana , Abd Razak Siti Suraya , Wan Mohamad Saferdin Wan Fatimah Hanun , Firdaus Ummi Farhani
Published: April 2024

This research focuses on the ombudsman in Malaysia and its importance in strengthening good governance in civil state service. Public complaints towards maladministration and abuse of power of the government administrators or authorities have always been an issue that must be resolved in order to ensure that the government authorities are performing their functions within their jurisdictions. Ombudsman has been introduced in European countries to settle maladministration issues. In Malaysia, the current ombudsman system is adopted by the OFS which is situated in Kuala Lumpur and Integrity and Ombudsman Unit Sarawak (UNIONS) under the Premier Department of Sarawak. The implementation and effectiveness of ombudsman system will be analysed and comparison will be made to Sweden, Finland, Denmark, Norway and United Kingdom; which have adopted and practised ombudsman in their systems; particularly with regards to administrative law issues. This study shall improve the society’s awareness on the importance of ombudsman as one of the alternatives to resolve public complaints towards government administrators.
U.S. Development Assistance, Democratization and State-Building in Bosnia and Herzegovina
Authors: Yağcı Sait , Lopez Pedro
Published: April 2024

This article investigates the U.S. development assistance role in democratization, state-building and sustainable growth in Bosnia and Herzegovina. The OECD and USAID reports and selected projects (2015-2022) were used to examine and analyze the U.S. development assistance in the democratization process and state-building. The statistical data on the U.S. aid allocation and projects comes largely from the OECD's annual publications and USAID reports. Because of different periods, approaches and priorities, this paper placed the U.S. development assistance in the historical context. The analysis of different democratization and state-building projects indicated the extent to which the programs implemented have generated desired progress and development.
Malaysian Government's Unified Approach to Address National Food Security
Authors: Syafuddin Tan Mohd Zulhelmi , Bakar Ahmad Naqiyuddin , Ahmad Yarina
Published: April 2024

In Malaysia, following the COVID-19 disruption of food supply, the Cabinet Committee of National Food Security Policy was set up in 2020 as a whole-of-government effort to bring together strategies and action plans for food security at the national level. This study looks at how the policies of different ministries and central agencies match up with the progressive direction set by the committee. Even though there are varying focuses on the policies between the government bodies, a collective synergy emerges from their efforts. A document analysis of these key policies shows the government's commitment to ensuring enough food for everyone.
Importance and Signicance of Self-Reliance Principle on the Development of the Malaysian Defense Industry
Authors: Mohamed Ahmad Shah Pakeer , Abdul Batau Mohamed Fajil , Ismail Shahril Eashak , Ismail Mohd Faiz
Published: April 2024

To ensure the security of the nation, the Malaysian government has put in place an imperative guideline in its Defense Policy, in which the Defense Industry must have a self-reliance capability and should not be too depended on foreign defense assets. This is essentially the basic principle in which most nations would put into place in the effort to strengthen their defense and military capability. Perhaps due to its importance, it should be considered as the main component for the development of Malaysia’s Defense Policy. The issue of being overly dependent on foreign defense assets have been going on for years, and even now the Malaysian Defense Industry is still incapable of fulfilling the needs of the Malaysian Armed Forces. The aim of this paper is to analyze, and highlight the importance of self-reliance principle to ensure the growth of Malaysia’s Defense Industry, would enhance the combat capability and advancement of Malaysia’s Military assets.
Unlocking Second Chances: Scoping review of the parole system and the path to successful community reintegration in Malaysia
Authors: Marasan Munira , Puteh Fadilah , Kassim Asiyah
Published: April 2024

This paper intends to explore the parole system and how the system can assist with the successful reintegration of parolees back to the societies. Being ex-convicts, they face several challenges, such as lack of employment opportunities and discrimination, which hinder successful parole reintegration. The parole system, however, can be used to implement reintegration strategies to create change. Despite the abundance of studies on how employers perceive ex-convicts, there needs to be more research on the success of their reintegration into the workforce and society. This paper employs scoping review methods by identifying the existing literature about the parole system in Malaysia and the successful reintegration strategies. This paper concludes that the Malaysian parole system has unique features through the strategies implemented toward the effective reintegration of parolees.
Financial Management Policy and Governance for the Preservation of the UNESCO World Heritage Site in Malaysia as a Tourism Attraction
Authors: Che Soh Mazlan , Abdul Rahim Memiyanty , Zainuddin Azizan , Soegiono Agie Nugroho
Published: April 2024

Tourism in developing countries especially in Malaysia faces challenges between economic development and sustainable tourism, especially in promoting heritage assets and sites. A comprehensive policy together with proper governance needs to be revised to tackle this issue. It is necessary to analyze and understand the current policy and propose how the Malaysian government can establish a comprehensive method of managing heritage assets in Malaysia through sustainable UNESCO world heritage tourism. This study urges the proposed benchmarking study on Malaysia”s documentation (to be compared to Indonesia) to assess the adequacy of the policy and governance in preserving the UNESCO world heritage site in Malaysia (Lenggong Valley).
Green City Development: An analysis of green open space concept and its strategies in the urban context
Authors: Mohamed Nabilaa , Vadevelo Thenmolli , Mohd Zain Zarina , Putera Roni Ekha
Published: April 2024

Green Open Space (GOS) refers to any publicly accessible green park located within or near the city or metropolitan areas. This paper introduces a Green Open Space-Green City Conceptual Framework (GOS-GCCF) and its strategies for implementing GOS based on the urban context of Shah Alam City. Semi-structured interviews were conducted to analyse the strategies that emphasise the important roles of GOS in Green City Development (GCD) across economic, social, and environmental aspects. The study addresses various gaps in the Green City (GC) field through GOS implementation. It integrates the existing GC framework into actionable GOS-GCCF and strategies.
Subsidence and sedimentation dynamics of the lakeside part of the Rita River delta in the rupture zone, the northwestern coast of Lake Baikal
Authors: Lunina Oksana , Gladkov Anton
Published: April 2024

Delta subsidence is one of the key problems of human life as these areas are developed quite fast. The process is natural and depends on many factors, the influence of which has not yet been sufficiently studied. This study is aimed to identify changes in the earth’s surface of the lakeside part of the Rita River delta on the northwestern coast of Lake Baikal, where a zone of seismically induced gravitational ruptures were recently mapped. To assess topographic changes, we used the calculation of the difference in multi-temporal digital surface models (DSM) obtained in two local areas from ultra-high resolution unmanned aerial photography in 2020 and 2021. We established that the subsidence of the lakeside part of the delta occurred on average by 5–10 cm over 11 months and 19 days. These values are associated with natural sediment compaction. In places of their accumulation, aggradation occurs by similar values, compensating the balance of deposits. In the seismically induced gravitational failures in the absence of alluvium, subsidence reached 33–37 cm, which indicates active endogenous and exogenous processes in the Kocherikovsky fault zone. The largest negative and positive vertical topographic changes up to 40 cm occurred within the beach and were associated with wave-cutting activity. The most extreme swampy part of Cape Rytyi experienced the maximum subsidence per a year. The greatest accumulation of alluvium occurred in the southern section of the Rita River delta in a settling expressed in the surface and coinciding with the zone of recent ruptures, as well as in an accumulative flow that overlaps the zone of surface deformations. With the exception of this part, discontinuities are well exhibited on DSM that means they continue to develop despite intensive sedimentation. Comparison of multi-temporal DSM and DTM by calculating the difference in elevation for each node (pixel) of the model is a promising and inexpensive method for monitoring surface deformations.
RESUSITASI NEONATUS DAN PEDIATRIK
Authors: Givano Muhamad Randy , Widyastuti Yunita , Sari Djayanti
Published: April 2024

Diperkirakan 10% bayi baru lahir membutuhkan bantuan  untuk bernafas pada saat lahir dan 1 % saja yang membutuhkan resusitasi yang ekstensif. Penilaian awal saat lahir harus dilakukan pada semua bayi baru lahir. Dengan adanya faktor resiko yang dikenali sejak awal dapat membantu melakukan idenifikasi bayi baru lahir yang membutuhkan resusitasi, walaupun harus selalu dipersiapkan untuk resusitasi pada bayi tanpa faktor resiko. Depresi neonatus paling sering disebabkan oleh asfiksia intrauterin selama proses persalinan, yang dapat disebabkan hipotensi maupun hipoksia maternal, kompresi plasenta, insufisiensi uteroplasenta yang berujung pada hipoksia janin yang progresif dan asidosis laktat.

Kebutuhan akan resusitasi jantung paru pada kelompok umur pediatrik dikatakan jarang setelah periode neonates. Kejadian henti jantung pada pediatrik biasanya dikarenakan oleh kondisi hipoksemia yangberhubungan dengan gagal nafas atau obstruksi jalan nafas. Tidak seperti Dewasa, penyebab henti jantungpada infan dan anak biasanya bukan dari hasil suatu penyakit jantung primer.

Penilaian jalan nafas, pernafasan dan sirkulasi pada resusitasi merupakan hal yang sederhana. Pastikan jalan nafas terbuka dan bersih. Pastikan pernafasan, dalam keadaan spontan atau dibantu dan sirkulasi darah yang teroksigenasi adekuat.
The Impact of Indonesia’s Village Fund (Dana Desa) on Village Head Election
Authors: Anshari Khairullah , Khaidir Said , Marthalina
Published: April 2024

Through the implementation of the Village Law in 2014, the Indonesian government seeks to promote rural development and village autonomy by decentralizing power. The 2014 Village Law has two important points: the village fund and the extension of a village head’s term. This article tested to what extent the village fund has impacted the village head election and whether the village fund has improved villagers’ political participation in running for the village head election. The method used in this study is quantitative through a survey of 96 random village head candidates in the 2016 village head election in 117 villages in Banjar Regency, South Kalimantan. The findings show that the village funds have an impact on the quality of the nomination of village heads and facilitate the public’s involvement in the election. This phenomenon underscores the importance of village funds in encouraging democratic practices and the grassroots community’s participation in village governance. Changes in regulations of village fund implementation influence the participation of village residents in running for village head election, encouraging them to participate in the democratic process at the village level.