Clinical Outcomes of Revision Total Knee Arthroplasty among Different Etiologies and Treated with a Condylar Constrained Knee Implant Supported with Cones
Authors: Jannelli Eugenio , Ivone Alessandro , Rossi Stefano , Ghiara Matteo , Castelli Alberto , Pasta Gianluigi , Annunziata Salvatore , Torriani Camilla , Mosconi Mario , Benazzo Francesco 
Published: October 2022

The first objective of this paper is to report the clinical and functional results of a cohort of patients who underwent total knee arthroplasty revision at mid–long-term follow-up. The second objective is to investigate possible differences in postoperative functional and clinical outcomes between preoperative-cause-of-revision groups. Methods: we collected data from 105 surgeries performed between January 2008 and December 2014. Eighty-five of these patients were divided into subpopulations according to the causes of revision in order to study differences regarding their outcome. All the patients underwent a standard follow-up protocol with clinical and radiological exams at 1, 3, 6, 12, 24, and 36 months and at last follow-up. During the last follow-up, patient-reported outcome measures (PROMs) were used. We implemented the functional outcomes obtained with clinical data determined by the Oxford knee score (OKS), EQ-VAS, EQ-5D-5L, Knee Society Score (KKS), and range of motion (ROM). Statistically significant differences among the medians of the groups of OKS, EQ-VAS, EQ-5D-5L, KKS, and ROM (p < 0.05) were noticed. The Dunn’s test was used to perform post hoc comparisons, and it determined where the differences lie. Results: the median follow-up was 99 months (interquartile range (IQR) 80–115). The median age was 71.5 IQR 65.1–74.8)) with no relevant differences between the groups. More patients presented a preoperative diagnosis of aseptic loosening (29%), malpositioning (28%), and infection (24%), while a preoperative diagnosis of instability (11%) and periprosthetic fracture was observed in fewer cases. For OKS, the highest median value was in the periprosthetic fracture group (43.25, IQR 32.7–45.3) and the lowest median value was in the infection group (24.8, IQR 17.4–34.8). For EQ-VAS, the highest median value was in the periprosthetic fracture group (73.0, IQR 67.0–78.0) and the lowest median value was in the instability group (39.0, IQR 36.0–48.0). For EQ-5D-5L, the highest median value was in the aseptic loosening group (0.81, IQR 0.74-0.85) and the lowest median value was in the infection group (0.44, IQR 0.32–0.60). For KKS, the highest median value was in the aseptic loosening group (84.0, IQR 81.0–88.0) and the lowest median value was in the malpositioning group (56.5, IQR 49.4–66.0). For ROM, the highest median value was in the periprosthetic fracture group (105.0°, IQR 96.0–111.0°) and the lowest median value was in the infection group (88.5°, IQR 77.5–98.0°). Conclusion: Constrained condylar knee (CCK) prostheses can also be considered a good option to manage difficult cases of total knee arthroplasty revision, with satisfactory results being maintained over time; a preoperative diagnosis of infection is associated with a worse clinical and functional outcome.