bluuebunny/crossref_metadata_2025 huggingface dataset:
SOCIO-POLITICAL EVENTS IN UKRAINE IN THE DISCOURSE OF DONETSK MASS MEDIA OF GREEK NATIONAL MINORITIES (2014–2015)
Authors: Benchuk Vitalii
Published: December 2020

The article reveals the coverage of the Donetsk national media of Greek national minorities in socio-political events in Ukraine in 2014-2015. The following newspapers were used for the study – «Hellenes of Ukraine», «Chronos», «Kambana» and «Selskaya Nov». As a result, the author concludes that the primary task for the Greek media was to convey their position on the events of that time, which was to support the unity of Ukraine. Later, they expressed the attitude of Greek society to the Revolution of Dignity, Russia’s armed aggression, which, despite isolated critical materials, reflected the official state position. However, in some materials of «Selskaya Nov» ideological stamps were spread, which posed a threat to the information security of Ukraine, which was apparently due to its subordination to the district authorities, which belonged to the team of the Party of Regions. As a result, the coverage and analysis of the discourse of Donetsk mass media of Greek national minorities on socio-political events in Ukraine showed that at the initial stage their main goal was to convey the official position of the FGSU on the latter. In the future, the main source of information was the newspaper «Ellina Ukrainy», as the official bulletin of FGSU. However, its pages also contained critical material that contradicted the official position of Greek society. Also later, explanations began to appear regarding the Revolution of Dignity, armed aggression in the vision of the Greeks, which reflected the Ukrainian view of these events. Only Selkaya Novy periodically published materials that reflected hostile ideological clichés, in particular about the «civil war». This trend continued throughout 2014, but the following year, with the appointment of a new local government, the newspaper’s editorial policy changed.
VASYL IVANYS AND HIS VIEWS ON THE PAST AND FUTURE OF THE CAUCASUS
Authors: Novak Bohdan
Published: December 2020

Vasyl Ivanys (1888-1974) is an extraordinary personality of the Ukrainian political and cultural world of the XX century. He was a politician and public figure, engineer, economist, publicist and historian. Exept this, the person of Vasyl Ivanys is interesting because he, as a native of the North Caucasus, directly knew this part of the world, its history, the course of the revolutionary events of 1917-1921, and, unlike other famous figures of Kuban or Ukraine at that time, left a complex idea of the region in the published work «On the problem of the Caucasus». The ideas and views expressed in this publication are the subject of this paper. In addition to «On the problem of the Caucasus», the source base includes the first two volumes of Vasyl Ivanys memoirs of «Paths of Life», publications «Another tragedy of the Cossacks» and «The Kuban struggle for independence». The article pays a lot of attention to the identity of Vasyl Ivanys, which was due to its origin. First of all, he was a Cossack, a native of the North Caucasus, but at the same time he felt his belonging to the Ukrainian cultural space. His publication «On the Problem of the Caucasus» focuses mainly on the ancient history of the region, Russia’s conquest of the Caucasus, the resettlement of the Cossacks in the Kuban, the revolution of 1917-1918 in the North Caucasus and the future of this part of the world. The author of the article concludes that Ivanys views on the history and future of the Caucasus region, expressed in the «On the problem of the Caucasus», due to the origin and its political orientation. The Kuban occupies a central place in the publication, but Vasyl Ivanys covers its history in the general historical context and emphasizes its belonging to the North Caucasus. Although «On the Problem of the Caucasus» is based on extensive bibliographic material, but has a journalistic character. At the same time, Ivanys publication remains one of the few generalizations in Ukrainian historiography that covers the history of the Caucasus from ancient times to the second half of the XX century, gives an idea of the economic and cultural potential of the region and reflects the geopolitical ideas prevailing in Ukrainian politics emigration.
Topography of eye diseases in pathological changes in the gene PAX6
Authors: Кадышев В.В. , Васильева Т.А. , Марахонов А.В. , Куцев С.И. , Зинченко Р.А.
Published: December 2020

Исследования наследственной патологии органа зрения на фоне широкой генетической гетерогенности и выраженного клинического полиморфизма затруднены по причине сложности определения очага первичного повреждения. Часто заболевания переднего отрезка глаза являются пусковыми для повреждения заднего отрезка (сетчатки, хориоидеи, зрительного нерва). В представленном сообщении описана структура спектра РАХ6-ассоциированной патологии органа зрения в клинически полиморфной выборке с учетом уровня поражения глазного яблока.

Studies of hereditary pathology of the eye against the background of broad genetic heterogeneity and pronounced clinical polymorphism are difficult because of the complexity of determining the focus of primary damage - often diseases of the anterior segment of the eye are triggers for damage to the posterior segment (retina, choroid, optic nerve). The presented report describes the structure of the spectrum of PAX6-associated pathology of the eye in a clinically polymorphic sample, taking into account the level of damage to the eyeball.
Autosomal recessive cataract (CTRCT18) in Yakutia: results of molecular genetic studies
Authors: Барашков Н.А. , Коновалов Ф.А. , Чердонова А.М. , Борисова Т.В. , Соловьев А.В. , Терютин Ф.М. , Пшенникова В.Г. , Сапожникова Н.В. , Вычюжина Л.С. , Бурцева Т.Е. , Платонов Ф.А. , Хуснутдинова Э.К. , Посух О.Л. , Федорова С.А.
Published: December 2020

В работе представлены результаты молекулярно-генетических исследований врожденной формы катаракты (CTRCT18, MIM 610019), распространенной в Якутии.

We present the results of molecular genetic studies of the congenital cataract (CTRCT18, MIM 610019) common in the Sakha Republic of Russia.
Usher syndrome gene mutation spectrum in Russian patients
Authors: Иванова М.Е. , Демчинский А.М. , Каймонов В.С. , Миронова И.В. , Володин И.В. , Зинченко Р.А. , Стрельников В.В.
Published: December 2020

Изучение спектра мутаций и совершенствование диагностики синдрома Ашера (СА) особо актуальны в связи с разрабатываемыми подходами к генной терапии заболевания. Среди 46 пациентов с признаками СА патогенные мутации выявлены нами у 40 (87%) пациентов. СА I и II типов определены у 26% и 57% пробандов исходной выборки, соответственно. У пациентов с СА I выявлены мутации в генах MYO7A (73%), CDH23 (7%), PCDH15 (7%), и USH1C (13%). Наибольшую частоту показала мутация MYO7A p.Q18*. Описано 6 новых мутаций в гене MYO7A, и две - в гене PCDH15. У пациентов с СА II выявлена 21 мутация гена USH2A, 5 из которых описаны впервые. Наибольшую частоту показала мутация USH2A p.W3955*. У двух пациентов выявлены мутации в генах несиндромального пигментного ретинита RHO и RPGR, что позволило уточнить клинический диагноз.

Studying the mutation spectrum and improvement of molecular verification of the Usher syndrome (USH) are of particular relevance as gene therapy emerges. Among 46 patients with signs of Usher syndrome we identified mutations in 40 (85%) patients, establishing a diagnosis of USH1 and USH2 for 26% and 57% of the probands of the initial sample, respectively. Patients with USH1 showed mutations in the MYO7A (73%), CDH23 (7%), PCDH15 (7%), and USH1C (13%) genes. MYO7A p.Q18* mutation showed the highest frequency. We have identified 6 new mutations in the MYO7A gene, and 2 in the PCDH15 gene. In USH2 patients, 21 USH2A gene mutations were identified, 5 of which are novel. The USH2A mutation p.W3955* was most frequent. Two patients showed mutations in the non-syndromic retinitis pigmentosa genes RHO and RPGR, which made it possible to clarify the clinical diagnosis.
Genetics in Ophthalmology
Authors: Рудник А.Ю. , Федяков М.А. , Глотов О.С.
Published: December 2020

На сегодняшний день в базе данных Online Mendelian Inheritance in Man (OMIM) описано более 6613 заболеваний и фенотипов, 4241 имеют доказанную генетическую основу, не менее 45% вкючают офтальмологические проявления. В статье приведен ряд клинический примеров пациентов с офтальмологическими симптомами различных генетических заболеваний (алкаптонурия, болезнь Штаргардта, синдром микроцефалии с или без хориоретинопатии; астроцитарная гамартома) с целью демонстрации эффективного клинико-диагностического скрининга генетической патологии у пациентов.

So far, the Online Mendelian Inheritance in Man (OMIM) database describes more than 6613 diseases and phenotypes, 4241 have a proven genetic basis, 45% of which are combined with ophthalmological manifestations. The article provides a number of clinical examples of patients with ophthalmological manifestations of various genetic diseases (alcaptonuria, Stadgart ‘s disease, microcephaly syndrome with or without choriretinopathy; Astrocytic gamartoma) to demonstrate effective clinical-diagnostic screening of genetic pathology in patients.
Polymorphisms rs7865618 and rs2157719 of the CDKN2B-AS1 gene and the development of primary open-angle glaucoma in women from the Central Region of Russia
Authors: Елисеева Н.В.
Published: December 2020

В последние десятилетие проведение полногеномного поиска ассоциаций глаукомы позволило определить ассоциированные с ней полиморфные локусы. Проведено репликативное исследование ассоциаций GWAS-значимых полиморфных локусов rs7865618 и rs2157719 гена CDKN2B-AS1 с развитием первичной открытоугольной глаукомы в выборке из 290 больных с глаукомой, и 220 человек контрольной группы. Установлено, что у пациентов с глаукомой женского пола частота генотипа АА полиморфного локуса rs7865618 гена GDKN2B-AS1 составила 34,98%, AG - 46,64%, GG - 13,37%, минорного аллеля А - 41,70%. У женщин контрольной группы определены следующие частоты полиморфного локуса rs7865618: АА - 28,30% , AG - 51,42%, GG - 20,28%, минорный аллель А - 45,99% соответственно. У больных глаукомой частота генотипа АА rs2157719 гена GDKN2B-AS1 была равна 39,01%, AG - 48,40%, GG - 18,72%, минорного аллеля G - 42,49%, а у женщин контрольной группы частота генотипа АА составила 32,88%, AG - 48,40%, GG - 18,72%, минорного аллеля G - 42,49% соответственно. Полиморфизмы rs7865618 и rs2157719 гена GDKN2B-AS1 не ассоциированы с первичной открытоугольной глаукомой у женщин Центрального Черноземья РФ.

In the past decade, a genome-wide search for glaucoma associations has identified the associated polymorphic loci with glaucoma. Goal: replicative studies of associations of significant polymorphic loci rs7865618 and rs2157719 of the CDKN2B-AS1 gene with the development of primary open-angle glaucoma in women from the Central Black Earth Region of the Russian Federation. The object of the study was a sample of 290 patients with glaucoma, and 220 people in the control group. It was found that in patients with female glaucoma the frequency of the AA genotype of the polymorphic locus rs7865618 of the GDKN2B-AS1 gene was 34.98%, AG - 46.64%, GG - 13.37%, minor allele A - 41.70%. In women of the control group, the following frequencies of the rs7865618 polymorphic locus were determined: AA - 28.30%, AG - 51.42%, GG - 20.28%, minor allele A - 45.99%, respectively. For rs2157719 of the GDKN2B-AS1 gene among glaucoma patients, the frequency of the AA genotype was 39.01%, AG - 48.40%, GG - 18.72%, the minor G allele was 42.49%, and in the women in the control group, AA - 32.88%, AG - 48.40%, GG - 18.72%, minor allele G - 42.49%, respectively. Conclusions. Polymorphisms rs7865618 and rs2157719 of the GDKN2B-AS1 gene are not associated with primary open-angle glaucoma in women of the Central Region of the Russian Federation.
Genetic architecture of osteogenesis imperfecta in the Republic of Bashkortostan
Authors: Зарипова А.Р. , Минниахметов И.Р. , Хусаинова Р.И. , Тюрин А.В. , Скрябин Н.А. , Короткая Т.С. , Захарова Е.Ю.
Published: December 2020

Несовершенный остеогенез (НО) (МКБ-10: Q78.0, несовершенный остеогенез) - клинически и генетически гетерогенное наследственное заболевание соединительной ткани, в основе которого лежат генетические изменения, приводящие к нарушению структуры костной ткани. Идентифицирован 21 ген, вовлеченный в патогенез НО, но пока не выяснена степень генетической гетерогенности заболевания. Целью исследования являются поиск молекулярной причины НО и определение типа наследования и клинической формы заболевания на основе анализа клинико-генетических корреляций.

Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous hereditary disease of the connective tissue, which is based on genetic changes leading to a violation of the structure of bone tissue. 21 genes are involved in the pathogenesis of OI have been identified, but the degree of genetic heterogeneity of the disease has not yet been clarified. The aim of the study is to search for the molecular cause of OI and determine the type of inheritance and the clinical form of the disease based on the analysis of clinical genetic correlations.
Molecular genetic analysis of the EXT2 gene - causes of hereditary multiple exostoses in Yakuts
Authors: Яковлева А.Е. , Петухова Д.А. , Данилова А.Л. , Сухомясова А.Л. , Максимова Н.Р.
Published: December 2020

В статье представлены результаты молекулярно-генетических исследованиий больных с множественной экзостозной хондродисплазией (МЭХД), причиной которой явилась редкая мутация в гене EXT2. Исследованы 65 больных с МЭХД и их родственников из 30 неродственных семей. Для молекулярно-генетического анализа было использовано массовое параллельное секвенирование и прямое секвенирование по Сэнгеру. У 16 больных из 4 семей с клиническим диагнозом МЭХД была выявлена редкая нонсенс-мутация c.751С>T в экзоне 5 гена EXT2 в гетерозиготном состоянии.

Here we present molecular genetic studies of Yakut patients with hereditary multiple exostoses (HME), which caused by a rare mutation in the EXT2 gene. A total of 65 patients with clinical diagnosis of HME and their relatives from 30 unrelated families were examined. For molecular genetic analysis, massive parallel sequencing (MPS) and direct Sanger sequencing were used. In 16 patients from 4 families with a clinical diagnosis of HME, a rare heterozygous nonsense mutation c.751C> T was detected in exon 5 of the EXT2.
Genetic structure of a predisposition to the progression of liver fibrosis of various etiologies
Authors: Гончарова И.А. , Назаренко М.С. , Белобородова Е.В. , Марков А.В. , Пузырев В.П.
Published: December 2020

Проведен сравнительный анализ генетической структуры предрасположенности к прогрессированию фиброза печени при хроническом вирусном гепатите С (ХВГС) и алкогольной болезни печени (АБП). С циррозом печени при ХВГС ассоциирован генотип СС rs708272 гена CETP (OR=4,08 [95%CI:1,69-10,03]; р=0,001). С алкогольным циррозом ассоциирован генотип CG rs12054703 гена NUP155 (OR=1,86 [95%CI:1,11-3,13]; р=0,016). Генотип CG rs7590760 гена DNMT3A является протективным относительно развития алкогольного цирроза (OR=0,43 [95%CI:0,24-0,78]; р=0,004). Таким образом, выявлено, что генетическая компонента предрасположенности к циррозу печени различна для этиологически разных форм заболевания.

We performed the comparative analysis of the genetic structure of a predisposition to the progression of liver fibrosis in HCV-related infections and alcoholic liver disease. Genotype СС rs708272 of CETP gene was associated with cirrhosis in HCV-infected patients (OR=4,08[95%CI:1,69-10,03]; р=0,001). Genotype CG rs12054703 of NUP155 gene was associated with alcoholic liver cirrhosis (OR=1,86[95%CI:1,11-3,13]; р=0,016). Genotype CG rs7590760 of DNMT3A gene had protective effect on the alcoholic liver cirrhosis (OR=0,43[95%CI:0,24-0,78]; р=0,004). The genetic structure of a predisposition to liver cirrhosis is different for chronic hepatitis C virus infection and alcohol-induced liver injury.
The role of the TNF (rs1800629), TNFB (rs2239704) and TNFRSF1B (rs652625) genes polymorphic variants in the allergic and infectious disease's development
Authors: Жалсанова И.Ж. , Брагина Е.Ю. , Бабушкина Н.П. , Тарасенко Н.В. , Назаренко М.С. , Пузырев В.П.
Published: December 2020

В настоящем исследовании установлены ассоциации полиморфных вариантов генов TNF (rs1800629), TNFB (rs2239704) и TNFRSF1B (rs652625) с развитием бронхиальной астмы и туберкулеза. Различия в характере транскрипции гена TNF в зависимости от генотипа и воздействия стимуляторов микробного/немикробного происхождения (LPS, IFN-γ) предполагают функциональную значимость однонуклеотидной замены G>A (rs1800629) в гене TNF.

In the present study, we established associations of the genes TNF (rs1800629); TNFB (rs2239704) and TNFRSF1B (rs652625) with the development of bronchial asthma and tuberculosis. Differences in the TNF gene transcription pattern depending on the genotype and the effect of stimulators of microbial/non-microbial origin (LPS, IFN-γ) suggest the functional significance of the single nucleotide substitution G>A (rs1800629) of the TNF gene.
MicroRNA role in hereditary genetic diseases
Authors: Плотникова О.М. , Скоблов М.Ю.
Published: December 2020

На сегодняшний день известно около 7000 наследственных заболеваний. Однако современные методы ДНК диагностики выявляют причину возникновения заболеваний примерно в 40% случаев. Отчасти это обусловлено сложностью и большим разнообразием молекулярных механизмов их патогенеза. МикроРНК являются одним из мощнейших регуляторов экспрессии генов. Однако участие их в патогенезе наследственных заболеваний пока недостаточно изучено из-за сложностей поиска таких нарушений. В данной работе проведён анализ описанных механизмов патогенеза наследственных заболеваний, опосредованных нарушениями регуляции экспрессии генов посредством микроРНК. Такие случаи были выявлены при таких наследственных заболеваниях как муковисцидоз, миодистрофия Дюшенна, бета-талассемия, глаукома, лице-лопаточно-плечевая миодистрофия Ландузи-Дежерина, болезнь Гиршпрунга, синдром Ретта, синдром Туретта, пемфигус (болезнь Хейли-Хейли).

To date, about 7,000 hereditary diseases are known. However, modern diagnostic methods reveal the cause of the disease in about 40% of cases. This is partly due to the complexity and wide variety of molecular mechanisms of pathogenesis. MicroRNAs are one of the most powerful genes expression regulators. But their participation in the pathogenesis of hereditary diseases has not yet been studied enough because of the difficulties in finding such disorders. In this work, we collected and analyzed pathogenesis of hereditary diseases mediated by dysregulation of gene expression by microRNA. such cases have been identified for such hereditary diseases as cystic fibrosis, Duchenne muscular dystrophy, beta-thalassemia, glaucoma, facioscapulohumeral muscular dystrophy Landouzy-Dejerine, Hirschsprung disease, Rett syndrome, Tourette syndrome, pemphigus (Hailey-Hailey disease).
The study of paraquat genotoxicity by bacterial lux-biosensors
Authors: Мачигов Э.А. , Свиридова Д.А. , Абилев С.К.
Published: December 2020

Показано, что паракват (1,1-диметил-4,4дипиридилия дихлорид) индуцирует люминесценцию биосенсоров, несущих промоторы генов soxS и katG, специфично реагируюших на супероксид-анион радикал и перекись водорода, соответственно. Антиоксиданты глутатион и ацетилцистеин снижали уровень как люминесценции биосенсоров, так и разрывов ДНК в бактериальных клетках.

It has been shown that paraquat (1,1-dimethyl-4,4 dipyridylium dichloride) induces luminescence of biosensors carrying the promoters of the soxS and katG genes that specifically react to the superoxide anion radical and hydrogen peroxide. The antioxidants glutathione and acetylcysteine reduced the level of biosensor luminescence and DNA breaks.
Genotoxicity of cationic lipopeptide nanoparticles
Authors: Анисина Е.А. , Жанатаев А.К. , Лисицын А.А. , Шиловский И.Р. , Колоскова О.О. , Хаитов М.Р. , Дурнев А.Д.
Published: December 2020

Наночастицы при однократном и многократном введении увеличивают уровень повреждений ДНК в легких, печени и почках мышей, а также в клетках костного мозга in vitro. В условиях однократного и многократного введения наночастицы не индуцируют хромосомные аберрации в клетках костного мозга мышей.

A single and repeated doses of nanoparticles caused DNA damage in the liver, lung and kidney of mice as well as in the in vitro comet assay on bone marrow cells. No statistically significant increase in the percentage of cells with chromosomal aberrations was observed in mice treated with nanoparticles after a single or repeated injection.
The protective properties of the Achillea millefolium L. extract are relative to the toxic and genotoxic effects of etoside on the example of Drosophila melanogaster
Authors: Антосюк О.Н. , Орлова В.Н.
Published: December 2020

Используя различные концентрации экстракта Achillea millefolium L. выбрана 5%, демонстрирующая более выраженные протекторные свойства относительно токсического воздействия этопозида. Установили стимуляцию плодовитости при выращивании особей на питательной среде с экстрактом. Генотоксических проявлений у экстракта A. millefolium L. в 5% концентрации не обнаружили.

Using different concentrations of Achillea millefolium L. extract selected 5% demonstrating more pronounced protective properties regarding the toxic effects of etoposide. They have established stimulation of fertility in the cultivation of individuals on a nutrient medium with extract. Genotoxic manifestations in A. millefolium L. in 5% concentration were not found.
Molecular response of human skin fibroblasts with a mutation m. 14441 T>C on the action of ionizing radiation in low and medium doses
Authors: Абрамова М.С. , Конькова М.С. , Момот В.Ю. , Кальянов А.А.
Published: December 2020

В качестве модели для исследования были выбраны фибробласты с мутацией m.14441 T>C в гене ND6 и фибробласты здорового донора. Было показано, что данная мутация в гене ND6 митохондриальной ДНК (мтДНК) оказывает значительное влияние на ответ клеток во время окислительного стресса.

Fibroblasts with the mutation of m.14441 T>C in the ND6 gene and fibroblasts of a healthy donor were chosen as a research model. It was shown that this mutation in the ND6 mitochondrial DNA gene has a significant effect on the cellular response during oxidative stress.
The composition of the bacterial microbiome in the sputum of patients with lung cancer and the assessment of its effect on clastogenic effects in blood lymphocytes
Authors: Дружинин В.Г. , Баранова Е.Д. , Волобаев В.П. , Деменков П.С. , Мацкова Л.В.
Published: December 2020

Впервые дана оценка влияния качественных и количественных изменений состава бактериального микробиома в мокроте 17 пациентов, страдающих раком легкого, и 17 контрольных доноров на показатели цитогенетического гомеостаза соматических клеток. Доноры с высокими значениями (свыше 3,5 %) частот хромосомных аберраций (ХА) имели в микробиоме достоверное снижение представителей родов Prevotella, Selenomonas, Veillonella, а также увеличение представителей рода Kocuria по сравнению с донорами с низким уровнем ХА в лимфоцитах. На видовом уровне были обнаружены различия в содержании Anaerosinus glycerini, Selenomonas bovis, Actinomyces hyovaginalis, Granulicatella balaenopterae и Clostridium bolteae. При этом только последний вид был представлен чаще в мокроте доноров с высоким уровнем ХА, остальные 4 вида бактерий были достоверно чаще представлены в мокроте доноров с низким уровнем мутаций в лимфоцитах.

The impact of qualitative and quantitative changes in the composition of the bacterial microbiome in the sputum of 17 patients with lung cancer and 17 control donors on the parameters of somatic cell cytogenetic homeostasis was first assessed. Donors with high frequencies of chromosomal aberrations (CA) over 3.5 % had a significant decrease in the microbiome of the genera Prevotella, Selenomonas, Veillonella, as well as an increase in representatives of the genus Kocuria compared to donors with a low level of CA in lymphocytes. At the species level, differences were found in the contents of Anaerosinus glycerini, Selenomonas bovis, Actinomyces hyovaginalis, Granulicatella balaenopterae and Clostridium bolteae. Moreover, only the latter species was represented more often in the sputum of donors with high levels of CA, the remaining 4 types of bacteria were significantly more likely to be present in the sputum of donors with a low level of mutations in lymphocytes.
Cross-sectional study of cardiovascular disease awareness and therapy management among hypertensive patients in rural areas in the Nellore district of Andhra Pradesh State
Authors: Ismail Y  , Haja Nazeer Ahamed  , Vijaya Vara Prasad M  , Vadivelan Ramachandran
Published: December 2020

Recent Indian study protocol designed for the supervision of cardiovascular disease instructed as well as better therapeutic achievement underneath the accustomed cardiovascular disease inhabitants. After all, a few people (25%) of heart-related problems inhabitants being conscious, 80% of the people were treated; besides just 20% were composed. This study was conducted as a cross-sectional study laminated arbitrary examine and inspected during the period of 4th Mar 2017 to 3rd July 2017 in the form of order. The model framework was put up pedestal scheduled, the portal system of the area inhabitants record as of inhabitants in the sequence of Nellore. Analytical clue, hypertension situation, and way of life behavior of the contributors were revealed. Hereby observed hypertension occurrence, consciousness, therapy, management, and drugs. The study appearance 57.2% of observed inhabitants to exist confidential the same as blood pressure living being conscious of their earlier analysis of blood pressure. This deliberation has been observed as a laminated casual inspect characterizing the Indian developed inhabitants in city areas of Nellore, India. As well as-discussed training procedure was attended with employing a definitive covenant and tool and makes certain the superiority of the fact compilation agenda. This hypertension wellbeing control can be taught the communal base and it prevents the public from cardiovascular disease avoidance plan may be effectual and humanizing to manage the blood pressure.
Detection of diabetes mellitus using machine learning algorithms
Authors: Ramya. G. Franklin  , Muthukumar B
Published: December 2020

The growth of technology has brought in sophistication in our day to day activities. This sophistication has brought in many health issues. One among the most important problems that has currently become a typical issue is Diabetics Mellitus. Diabetes Mellitus has affected over 246 million people worldwide with a majority of them being women. The WHO reports that by 2025 this number is expected to rise to over 380 million. Prevention is better than cure. The health care data is large and complex. It is better to predict the disease at an earlier stage which may save the life and also have a preventive measure in controlling the diseases. In this paper, we have taken up a heterogeneous data to analyze the various factors which are affecting this disease. The various machine learning algorithms used in this paper help us to decide the attributes which play a major role in diagnosis of Diabetes Mellitus.
Full mouth rehabilitation of a patients with gastro-oesophagealal reflux disease - A case report
Authors: Preetham Prasad Nittla  , Deepak Nallaswamy V
Published: December 2020

Gastro esophageal reflux disease(GERD) is a chronic digestive disease caused by backwash (reflux) of stomach acid or contents into the esophagus or the oral cavity. Erosion of the teeth and subsequent wear is a common manifestation of GERD. This clinical report describes the dental rehabilitation of eroded maxillary and mandibular teeth along with other dental complaints in a 45-year-old female GERD patient. Full mouth rehabilitation of natural teeth together with metal-ceramic fixed partial dentures was selected as a treatment modality. Ideal occlusion, optimum esthetics, maintainable oral hygiene were all ensured for a favorable prognosis.
Analysis of microbial diversity of tea tree (Camellia sinensis (L.) O. Ktze.) sick rhizospheric soil using soil metaproteomic technology
Authors: Wang H.B. , Zhang Q.X. , Chen X.T. , Wang Y.H. , Lin L.W. , Ye J.H. , Zhang Q. , Jia X.L. , He H.B.
Published: December 2020

Soil metaproteomics technology was used to analyse and undertand the changes in microbial diversity in rhizospheric soil of Tieguanyin tea trees (Camellia sinensis (L.) O. Ktze.) of different ages. The results showed We identified 2911 protein spots in the rhizosphere soil of tea tree. These were derived from 388 species of microorganisms [331 species of bacteria (85.31 %) and 57 species of fungi (14.69 %)]. According to the analysis of microbial species in tea tree rhizospheric soil with different ages, the number of microbial species in 0, 4, 9 and 30-years old rhizospheric soils were 346, 350, 345 and 354, respectively. Among them, 310 microbial species co-existed in the rhizospheric soil with different ages tea trees. The analysis of results of microbial species and function showed that, as the tea tree age increased, the pathogenic microorganisms in its rhizospheric soil increased, while the microorganisms, for decomposing harmful substances, probiotics and microorganisms related to carbon cycle and nitrogen cycle decreased. The microbial structure and functions of tea tree rhizospheric soil changed significantly with increase in tea tree age.
Allelopathic effects of phenolic acids on germination of watermelon(Citrullus lanatus Thunb): Dose-effect relationship and quantitative structure-activity relationship
Authors: Li Min , Ma Lu , Song Yuan , Yan Xingfu , Lei Qian , Zhang Xiu
Published: December 2020

To determine the allelopathic potential of phenolic acids on watermelon (Citrullus lanatus Thunb), we studied the inhibitory activities of 21 phenolic acids on watermelon seeds germination. The quantitative structure-activity relationship (QSAR) method using the comparative molecular field analysis and comparative molecular similarity index analysis was used to elucidate the relationships between the inhibitory activities and structural characteristics. The results showed that half-maximal inhibitory concentrations (IC50) were in ~µg/mL. The QSAR calculations suggested that the allelopathic inhibitory activities were increased when substituents had large moieties at 1/2/3/4-positions, negative charge at 1/3-position, a H-bond donor at 4-position and a H-bond acceptor at 2-position.
Herbicidal potential of Aerva javanica to control wild oat in wheat crop
Authors: A.M. Al-Ghamdi , M El-Zohri
Published: December 2020

We investigated the phytotoxicity of desert cotton (Aerva javanica) extracts on wild oat and wheat. Aqueous extracts from A. javanica roots, leaves and inflorescences collected from Jeddah and Al-Baha regions, Saudi Arabia were used. Generally, the allelopathic potential of water extracts of A. javanica collected from Jeddah were more in inhibitory to wild oat germination and seedlings growth than those from Al-Baha. In both regions, root extracts were inhibitory to wild oat followed by leaves and inflorescences extracts. All test aqueous extracts of both regions did not inhibit the wheat germination or seedlings growth.Whreas, the wild oat germination was reduced by root extracts 58.62 %, 28.62 % leaves extracts : 32.72 %, 17.72 % and inflorescences extract 28.11 %, 12.13 % by in plants samples collected from Jeddah and Al-Baha, respectively. Wild oat radical length was inhibited by root extracts 53.27 %, 32.84 % leaves 42.35 %, 9.63 % and inflorescences extracts 22.64 %, 16.75 % in case of Jeddah and Al-Baha plants, respectively. In pot culture experiment, all treatments markedly reduced the plant dry weight and soluble carbohydrates, proteins and free amino acids contents in wild oat. The differences in the allelopathic potentials of studied A. javanica extracts were related to the qualitative variations in their phytochemicals constituents. Our results showed that A. javanica extracts could be safely used to control wild oat growth in wheat fields after more detsaled research..
ANALISIS PARTISIPASI ANGGARAN TERHADAP BUDGET SLACK: PERSEPSI KEWAJARAN PROSEDURAL DAN DISTRIBUTIVE, KEPERCAYAAN MANAJERIAL, DAN KOMITMEN TUJUAN ANGGARAN SEBAGAI FAKTOR INTERVENING
Authors: - Hardiwinoto
Published: December 2020

The aim this research to examine of the relationships between budget participation that influence manager’s propensity to create budget slack: procedural and distributive fairness, managerial trust, and budget goal commitment as intervening variable. The results show that budget participation impacts both procedural fairness and distributive fairness which, affect trust. Both, procedural and distributive fairness, are found to have a significant impact on budget goal commitment, and negatively influences managers’ propensity to create slack. Further analyses indicatethat the direct relationship between budget participation and manager’s propensity to create slack was insignificant, which suggests that fairness and goal commitment mediate the relationship between budget participation and manager’s propensity to create slack.Keywords: Budget, Distributive Fairness, Procedural Fairness, Trust, GoalCommitment, Budget Slack.
PENGARUH GOOD CORPORATE GOVERNANCE TERHADAP KINERJA SAHAM PERUSAHAAN (Studi Empiris pada Saham LQ 45 di BEI)
Authors: Karim Abdul
Published: December 2020

Corporate governance telah menjadi topik yang menarik untuk diteliti pada saat sekarang ini. Hal ini karena meningkatnya kebutuhan untuk menerapkan good corporate governance yang disuarakan secara global didorong oleh terjadinya skandal yang terjadi di Enron, Worldcom, Parmalat untuk perusahaan yang ada di Amerika serta PT. Agis sebagai contoh perusahaan di Indonesia yang disebabkan oleh kurangnya penerapan corporate governance yang baik. Skandal – skandal akuntansi tersebut tentunya akan berdampak terhadap ekonomi suatu bangsa melalui efeknya terhadap pasar modal. Penelitian ini mempunyai tujuan untuk menganalisis pengaruh komisaris independent, kepemilikan manajerial, kepemilikan asing, hutang, serta kualitas audit terhadap kinerja saham perusahaan yang termasuk dalam LQ 45 di Bursa Efek Indonesia tahun 2006 – 2008 dan untuk memberikan gambaran bagaimana penerapan good corporate governance yang berkembang pada perekonomian seperti sekarang ini. Berdasarkan hasil analisis dan pengujian, data menunjukkan tidak adanya pengaruh yang signifikan antara komisaris independent (INED) terhadap kinerja perusahaan, hal ini membuktikan bahwa tidak adanya pengaruh komisaris independent terhadap kinerja saham. Kemudian adanya pengaruh positif antara kepemilikan manajerial terhadap kinerja perusahaan, yang berarti bahwa semakin besar jumlah kepemilikan manajerial akan meningkatkan nilai perusahaan. Kemudian terdapat pengaruh positif signifikan antara kepemilikan asing terhadap kinerja perusahaan. Hal ini mengindikasikan bahwa para investor di Bursa Efek Indonesia ternyata juga memperhatikan jumlah kepemilikan asing dalam menilai suatu perusahaan. Kemudian analisis data menunjukkan bahwa terdapat pengaruh positif signifikan antara hutang dengan nilai perusahaan. Hal ini juga mengindikasikan bahwa para investor di Bursa Efek Indonesia memperhatikan pengawas lain akan suatu perusahaan. Hasil analisis data menunjukkan bahwa terdapat pengaruh positif signifikan antara kualitas audit dengan nilai perusahaan. Hal ini mengindikasikan bahwa kualitas audit yang digambarkan dengan kantor akuntan yang termasuk big 4 akan berpengaruh terhadap nilai suatu perusahaan. Kualitas audit biasanya mempengaruhi luasnya suatu pemeriksaan sehingga kredibilitas hasil audit bisa diandalkan.Keywords : GCG, komisaris independen, kepemilikan manajerial, kepemilikan asing, kualitas audit
PERILAKU RASIONAL PARA MANAJER DALAM PENGAMBILAN KEPUTUSAN PEMBIAYAAN MELALUI BANK SYARIAH
Authors: . Hardiwinoto .
Published: December 2020

Abstract This study aims to explore the underlying motivations of managers in corporate financing. The method Used is to explore the literature, the predecessor of research and related theories. The results showed that the motivation underlying the financing decision is rational behavior of the managers. Keyword : motivations of managers, financing decision making, and Rational behavior of the managers.
E\/ALUASI IMPLEMENTASI DAN PENGUATAN NILAI- NILAI DASAR PERSYARIKATAN MUHAMMADIYAH PADA AMAL USAHA MUHAMMADIYAH BIDANG PENDIDIKAN
Authors: Handari W Rr Sri
Published: December 2020

Abstract Muhammadiyah merupakan gerakan lslam amar ma'ruf nahi munkar yang memiliki amal usaha. pendidikan yang tersebar di hampir seluruh wilayah Indonesia. Salah satu faktor penguat perkembangan ini adalah nilai-nilai Kemuhammadiyahan yang mencakup ukhuwah, ikhlas, dan kesungguhan. Namun pendidikan dasar, menengah, dan umum, saat ini perlu mendapat perhatian, mengingat persaingan pendidikan yang semakin tinggi. Idealnya nilai nilai pendiri ( Founding Father) akan mampu menjadi daya dorong amal usaha pendidikan sehingga mampu berkiprah secara optimal dalam usaha pendidikan di Indonesia. Penelitian ini merupakan penelitian deskriptif eksploraiif yang bertujuan mengevaluasi implementasi nilai-nilai persyarikatan pada Amal usaha Muhammadiyah bidang pendidikan. Hasil penelitian diharapkan memberikan kontribusi pada peningkatan kinerja amal usaha Muhmmadiyah melalui penguatan nilai kerja yang didasarkan pada nilai dasar persyarikatan Muhammadiyah. Kata Kunci : Amal usaha Muhammadiyah, Nilai dasar persyarikatan
PENGARUH KARAKTERISTIK KOMITE AUDIT TERHADAP PENGUNGKAPAN INTELLECTUAL CAPITAL PADA PERUSAHAAN IC INTENSIVE YANG TERDAFTAR DI BEI
Authors: Arifah Dista Amalia
Published: December 2020

This study aims to analyze the influence of audit committee characteristics, which is consists of : audit committee membership, audit committee independence, independent commissioner proportion, audit committee chief and audit committee competence on the intellectual capital disclosure, companies used in the category of intensive ICs at BEI in 2009, also considering the control variables. The population included in the category of IC intensive companies amounted to 176. Sampling using a purposive sampling method and obtained 73 samples that meet the criteria.The data used in this study is secondary data, the annual report of the company in 2009 and processed by multiple regression. ICs disclosure acquisition data using content analysis techniques to the analysis unit that has been determined, the IC disclosure have been acquired in quantity and quality terms. The results showed that among audit committee characteristics that are used only audit committee membership and audit committee chief which affects the IC disclosure in quantity terms. While two other control variables which are size and profitability, showed different results. Only size was affected significantly in quality IC disclosure terms.
Keadilan Ekonomi dalam Perspektif Ekonomi Syariah: Sebuah Tinjauan Teori
Authors: - Suryani
Published: December 2020

Manusia telah diciptakan untuk menangani bumi ini untuk mencapai kemakmuran dan kebahagiaannya, dengan tidak boleh mengambil tindakan yang lain kecuali untuk menegakkan keadilan. Islam menghendaki supaya keadilan itu dapat dicapai dalam segala aspek hidup, termasuk politik, ekonomi, sosial, dan budaya. Komitmen Islam yang besar pada persaudaraan dan keadilan, menuntut agar semua sumber daya dimafaatkan untuk mewujudkan maqashid syari’ah, yakni pemenuhan kebutuhan hidup manusia, terutama kebutuhan dasar (primer), seperti sandang, pangan, papan, pendidikan dan kesehatan. Persaudaraan dan keadilan juga menuntut agar sumberdaya didistribusikan secara adil kepada seluruh rakyat melalui kebijakan yang adil melalui instrumen zakat, infaq, sedekah, pajak, kharaj, jizyah, cukai ekspor-impor dan sebagainya. Konsep keadilan sosio ekonomi dalam Islam berbeda secara mendasar dengan konsep keadilan dalam kapitalisme dan sosialisme. Keadilan sosio ekonomi dalam Islam, selain didasarkan pada komitmen spritual, juga didasarkan atas konsep persaudaraan universal sesama manusia.
Keterkaitan Corporate Governance Dengan Corporate Social Responsibility
Authors: Wibowo R. Ery , - Agung S
Published: December 2020

Makalah ini membahas tentang keterkaitan antara Corporate Gorvenance dengan Corporate Social Responsibility. Keduanya baik Corporate Social Responsibility (CSR) dalam perspektif teori legitimasi maupun Corporate Gorvenence keduanya saling melengkapi membentuk fungsi objektif dalam menghadapi kendala yang dihadapi oleh perusahaan. Disatu sisi CG dapat meminimalkan biaya agensi disisi lain CSR dapat mengatasi beban ilegitimasi dari stakeholdernya. Baik CG maupun CSR memiliki hubungan imbal balik yang membentuk fungsi yang mampu meningkatkan nilai perusahaan dan meningkatkan kinerja social dan kinerja keuangan dalam jangka panjang.
PENGARUH KEPATUHAN WAJIB PAJAK DAN PENAGIHAN PAJAK TERHADAP PENERIMAAN PPH PASAL 25/29 WAJIB PAJAK BADAN PADA KPP PRATAMA BATANG
Authors: Hanifah Imas Septiyani , Agung S R. Ery Wibowo
Published: December 2020

One of the things that influence the most of the acceptance of income tax article 25/29corporate taxpayers is the level of tax compliance, especially in BatangPratama Tax Office. The large amount of income tax revenue of article 25/29 corporate taxpayers nothing to do with the level of tax compliance, ie whether or not the obedient corporate taxpayers in paying taxes. The purpose of this study was to determine the effect of tax compliance and tax collection on income tax receipts article 25/29 corporate taxpayers in the BatangPratamaTax Office period 2008-2012. The survey was conducted at the BatangPratamaTax Office and units of analysis are secondary data from reports of receipts of income tax article 25/29 corporate taxpayers the period 2008-2012. Regression models were used in compliance with the classical assumption test. The data analysis technique used is the technique of multiple linear regression analysis using SPSS version 16.0 The results showed that in the period of 5 (five) years ie 2008 to 2012, the amount of income tax revenue of article 25/29 corporate taxpayers in the BatangPratama Tax Office continued to increase from year to year, tax compliance and collection tax simultaneously and partially significant effect on income tax receipts article 25/29 taxpayers on BatangPratamaTax Office period 2008-2012. Keywords: Taxpayer Compliance, Tax Billing, Tax Receipts Article 25/29, the Taxpayer.
ANALISIS PENERAPAN BALANCED SCORECARD SEBAGAI ALAT PENGUKURAN KINERJA (Studi Kasus: di BPRS Artha Surya Barokah Semarang)
Authors: Adiputri Ayuningtyas , Sinarasri Andwiani
Published: December 2020

The economic crisis a few years ago to make economic conditions in Indonesia have made great progress , so that requires leaders and company management to improve competitiveness by providing the best services for its customers in order to survive . One of the company's goal is to support their survival to earn profits . The company's main goal can be achieved if the maximum performance of the company and work well , because of the success and the success of an enterprise is the ability to generate profit and expand its business .The population in this study were clients and employees of PT . Surya Artha SRB Barokah Semarang . number of employees required sample is 45 people and the customer sample 99.88 or 100 people . The analytical method used is descriptive analysis .Results of the study is a financial ratio used is ROA , ROA and LDR . Results of this study indicate that the SRB Surya Artha Barokah Semarang from 2010 through 2012 can achieve cost effectiveness and generate optimal profits . Performance of the financial perspective shows good results even continue experiencing good growth . Results of this study indicate that explains that the market share in Semarang Barokah Surya Artha SRB increased to reach an average value of 161.88 % . Surya Artha SRB Barokah Semarang maintain competitiveness , interest rates , increasing mastery of market segments in order to meet customer needs . Surya Artha SRB Barokah Semarang start expanding operations by expanding the branch network , the development of a variety of products and services offered . It aims to improve after-sales service and provide additional benefits to our customers in order to still have the loyalty of the BPRS Artha Barokah Surya Semarang . Results of measurements describing the success ratio AETR increased efficiency , effectiveness and accuracy of the transactions conducted BPRS Artha Barokah Surya Semarang . Results of this study showed improvement indicated that employee productivity is increasing every year . This happens because in assessing the percentage of successful employee training SRB Surya Artha Barokah Semarang . Regarding the level of employee satisfaction shows the value of the overall average score of 4.03 . The figure shows the results of a good or satisfied . Keywords : financial perspective , customer perspective, internal business processes , learning and growt perspective
ANALISIS PERSEPSI NASABAH DAN PERKEMBANGAN UMKM SETELAH MEMPEROLEH PEMBIAYAAN MUDHARABAH (Studi Kasus BPRS Binama Kota Semarang)
Authors: Barokah Siti , Hanum Ayu Noviani
Published: December 2020

The purpose of this study was to analyze the perception and development of Micro, Small and Medium Enterprises between before and after obtaining the financing mudharabah of BPRS Binama Semarang City, viewed from the side of working capital, profits, employment and profits.Data that used is simple random sampling on the BPRS Binama. Of the population of 100 respondents, 50 respondents of samples used. Type of test used is a validity test, reliability test, and the sign rank test Wilxocon. Experiments were done using SPSS PASW 18 program.Based on research results of the descriptive analysis of the overall submission process until the liquefaction process, customers expressed easily in obtaining financing. From the test results the insignia wilxocon there is developmental differences the UMKM between before and after financing of mudharobah with details of the amount of working capital increased by 165%, turnover increased by 79%, total employment increased 33% and profits by 82%. Keywords: Perception, Financing Mudharabah, UMKM
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI MAHASISWA DALAM MEMAHAMI MATA KULIAH AUDITING (Studi empiris pada mahasiswa Jurusan Akuntansi di Fakultas Ekonomi UNIMUS dan UNISSULA Semarang)
Authors: Fuadiyah Ellya , Sukesti Fatmasari
Published: December 2020

This study aims to analyze the factors that students affect on understanding of auditing course. The study based on the motivation's theory that is developed by Maslow and Big Five Personality's theory that is introduced by Goldberg, then it use the variable understanding of auditing course, motivation, communication skills, and personality. The method used is survey research. Analytical instrument to examine the hipotheses and validity of this study uses Structural Equation Model (SEM), it uses AMOS 21.0 program. Whereas, the program that be used in this study for descriptive statistic and reliability analysis uses SPSS 16.0 program, with notice means and standard deviation for statistic descriptive and cronbach alpha value to determine reliability.The results showed that motivati on, communication skills, and personality a studens positive affect on understanding of auditing course. While communication skills no students positive effect on understanding auditing course. Keywords: auditing course, auditing course understanding, motivation, communication skills, personality