bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultra-conformable liquid metal particle monolayer on air/water interface for substrate-free E-tattoo
Authors: Li Fali , Lei Wenjuan , Wang Yuwei , Lu Xingjian , Li Shengbin , Xu Feng , He Zidong , Liu Jinyun , Yang Huali , Wu Yuanzhao , Shang Jie , Liu Yiwei , Li Run-Wei
Published: July 2023

Gallium-based liquid metal has gained significant attention in conformal flexible electronics due to its high electrical conductivity, intrinsic deformability, and biocompatibility. However, the fabrication of large-area and highly uniform conformal liquid metal films remains challenging. Interfacial self-assembly has emerged as a promising method, but traditional approaches face difficulties in assembling liquid metal particles. Here, we realized the multi-size universal self-assembly (MUS) for liquid metal particles with various diameters (<500 μm). By implementing a z-axis undisturbed interfacial material releasing strategy, the interference of gravitational energy on the stability of floating particles is avoided, enabling the fabrication of ultra-conformable monolayer films with large areas (>100 cm2) and high floating yield (50–90%). Moreover, the films can be conformally transferred onto complex surfaces such as human skin, allowing for the fabrication of substrate-free flexible devices. This eliminates interference from traditional substrate mechanical responses, making the liquid metal e-tattoo more user-friendly.
A systematic review of questionnaires measuring asthma control in children in a primary care population
Authors: Bousema Sara , Bohnen Arthur M. , Bindels Patrick J. E. , Elshout Gijs
Published: July 2023

Several questionnaires are used to measure asthma control in children. The most appropriate tool for use in primary care is not defined. In this systematic review, we evaluated questionnaires used to measure asthma control in children in primary care and determined their usefulness in asthma management. Searches were performed in the MEDLINE, Embase, Web of Science, Google Scholar and Cochrane databases with end date 24 June 2022. The study population comprised children aged 5–18 years with asthma. Three reviewers independently screened studies and extracted data. The methodological quality of the studies was assessed, using the COSMIN criteria for the measurement properties of health status questionnaires. Studies conducted in primary care were included if a minimum of two questionnaires were compared. Studies in secondary or tertiary care and studies of quality-of-life questionnaires were excluded. Heterogeneity precluded meta-analysis. Five publications were included: four observational studies and one sub-study of a randomized controlled trial. A total of 806 children were included (aged 5–18 years). We evaluated the Asthma Control Test (ACT), childhood Asthma Control Test (c-ACT), Asthma APGAR system, NAEPP criteria and Royal College of Physicians’ ‘3 questions’ (RCP3Q). These questionnaires assess different symptoms and domains. The quality of most of the studies was rated ‘intermediate’ or ‘poor’. The majority of the evaluated questionnaires do not show substantial agreement with one another, which makes a comparison challenging. Based on the current review, we suggest that the Asthma APGAR system seems promising as a questionnaire for determining asthma control in children in primary care.
Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants
Authors: Lyke Kirsten E. , Atmar Robert L. , Dominguez Islas Clara , Posavad Christine M. , Deming Meagan E. , Branche Angela R. , Johnston Christine , El Sahly Hana M. , Edupuganti Srilatha , Mulligan Mark J. , Jackson Lisa A. , Rupp Richard E. , Rostad Christina A. , Coler Rhea N. , Bäcker Martín , Kottkamp Angelica C. , Babu Tara M. , Dobrzynski David , Martin Judith M. , Brady Rebecca C. , Frenck Robert W. , Rajakumar Kumaravel , Kotloff Karen , Rouphael Nadine , Szydlo Daniel , PaulChoudhury Rahul , Archer Janet I. , Crandon Sonja , Ingersoll Brian , Eaton Amanda , Brown Elizabeth R. , McElrath M. Juliana , Neuzil Kathleen M. , Stephens David S. , Post Diane J. , Lin Bob C. , Serebryannyy Leonid , Beigel John H. , Montefiori David C. , Roberts Paul C. ,   the DMID 21-0012 Study Group, Anderson Evan J. , Berman Megan , Cohen Kristen W. , De Rosa Stephen , Dickey Michelle , Dong Jennifer Lee , Ellis Madison , Falsey Ann R. , Fleming Andrew B. , Floyd Katharine , Foster Stephanie L. , Graciaa Daniel , Kahn Ahsen , Kamidani Satoshi , Keitel Wendy A. , Lai Lilin , Larsen Sasha E. , Lee Marina , Manning Kelly , Moore Kathryn M. , Mulholland Vivian , Muniz Gysella B. , Nayak Seema , Noor Asif , Patel Mit , Porterfield Laura , Price Angie , Shannon Ian , Shope Timothy R. , Stanford Amber , Suthar Mehul S. , Wald Anna , Whitaker Jennifer A.
Published: July 2023

Abstract

As part of a multicenter study evaluating homologous and heterologous COVID-19 booster vaccines, we assessed the magnitude, breadth, and short-term durability of binding and pseudovirus-neutralizing antibody (PsVNA) responses following a single booster dose of NVX-CoV2373 in adults primed with either Ad26.COV2.S, mRNA-1273, or BNT162b2 vaccines. NVX-CoV2373 as a heterologous booster was immunogenic and associated with no safety concerns through Day 91. Fold-rises in PsVNA titers from baseline (Day 1) to Day 29 were highest for prototypic D614G variant and lowest for more recent Omicron sub-lineages BQ.1.1 and XBB.1. Peak humoral responses against all SARS-CoV-2 variants were lower in those primed with Ad26.COV2.S than with mRNA vaccines. Prior SARS CoV-2 infection was associated with substantially higher baseline PsVNA titers, which remained elevated relative to previously uninfected participants through Day 91. These data support the use of heterologous protein-based booster vaccines as an acceptable alternative to mRNA or adenoviral-based COVID-19 booster vaccines. This trial was conducted under ClinicalTrials.gov: NCT04889209.
Female-biased introductions produce higher predicted population size and genetic diversity in simulations of a small, isolated tiger (Panthera tigris) population
Authors: Ash Eric , Cushman Samuel , Kaszta Żaneta , Landguth Erin , Redford Tim , Macdonald David W.
Published: July 2023

Isolation of wildlife populations represents a key conservation challenge in the twenty-first century. This may necessitate consideration of translocations to ensure population viability. We investigated the potential population and genetic trajectory of a small, isolated tiger (Panthera tigris) population in Thailand’s Dong Phayayen-Khao Yai forest complex across a range of scenarios. Using an individual-based, spatially-explicit population modelling approach, we simulate population and genetic trajectories and evaluate the relative impact of translocations from a related population. Population and genetic trajectories in our study were most sensitive to sex and number of individuals translocated and translocation frequency. Translocation of females produced consistently higher population, allelic richness, and heterozygosity compared to equal numbers of males. Despite population increases, declines in allelic richness and heterozygosity across simulations were stark, with simulations predicting a mean decline of allelic richness and heterozygosity of 46.5% and 53.5% without intervention, respectively. Translocations of four females every generation or every other generation were required to prevent substantial heterozygosity declines. While translocations could increase population size, they may fail to prevent long-term loss of genetic diversity in small populations unless applied frequently. This reinforces the importance of incorporating realistic processes of genetic inheritance and gene flow in modelling small populations.
Effects of dialkoxybenzenes against Varroa destructor and identification of 1-allyloxy-4-propoxybenzene as a promising acaricide candidate
Authors: Dawdani Soniya , O’Neill Marissa , Castillo Carlos , Sámano Jorge E. Macias , Higo Heather , Ibrahim Abdullah , Pernal Stephen F. , Plettner Erika
Published: July 2023

The honey bee is responsible for pollination of a large proportion of crop plants, but the health of honey bee populations has been challenged by the parasitic mite Varroa destructor. Mite infestation is the main cause of colony losses during the winter months, which causes significant economic challenges in apiculture. Treatments have been developed to control the spread of varroa. However, many of these treatments are no longer effective due to acaricide resistance. In a search of varroa-active compounds, we tested the effect of dialkoxybenzenes on the mite. A structure–activity relationship revealed that 1-allyloxy-4-propoxybenzene is most active of a series of dialkoxybenzenes tested. We found that three compounds (1-allyloxy-4-propoxybenzene, 1,4-diallyloxybenzene and 1,4-dipropoxybenzene) cause paralysis and death of adult varroa mites, whereas the previously discovered compound, 1,3-diethoxybenzene, which alters host choice of adult mites in certain conditions, did not cause paralysis. Since paralysis can be caused by inhibition of acetylcholinesterase (AChE), a ubiquitous enzyme in the nervous system of animals, we tested dialkoxybenzenes on human, honey bee and varroa AChE. These tests revealed that 1-allyloxy-4-propoxybenzene had no effects on AChE, which leads us to conclude that 1-allyloxy-4-propoxybenzene does not exert its paralytic effect on mites through AChE. In addition to paralysis, the most active compounds affected the ability of the mites to find and remain at the abdomen of host bees provided during assays. A test of 1-allyloxy-4-propoxybenzene in the field, during the autumn of 2019 in two locations, showed that this compound has promise in the treatment of varroa infestations.
Association between preoperative C-reactive protein to albumin ratio and late arteriovenous fistula dysfunction in hemodialysis patients: a cohort study
Authors: Hu Shouliang , Wang Runjing , Ma Tean , Lei Qingfeng , Yuan Fanli , Zhang Yong , Wang Dan , Cheng Junzhang
Published: July 2023

Arteriovenous fistula (AVF) dysfunction is a critical complication in hemodialysis (HD) patients, with inflammation potentially contributing to its development. This retrospective cohort study aimed to investigate the association between preoperative C-reactive protein to albumin ratio (CAR) and AVF dysfunction in Chinese HD patients. A total of 726 adults with end-stage renal disease who underwent new AVF placement between 2011 and 2019 were included. Multivariable Cox regression and Fine and Gray competing risk models were employed to assess the relationship between CAR and AVF dysfunction, considering death and renal transplantation as competing risks. Among 726 HD patients, 29.2% experienced AVF dysfunction during a median follow-up of 36 months. Adjusted analyses revealed that higher CAR levels were associated with an increased risk of AVF dysfunction, with a 27% higher risk per one-unit increase in CAR. Furthermore, patients with CAR values ≥ 0.153 exhibited a 75% elevated risk compared to those with CAR values < 0.035 (P = 0.004). The relationship between CAR and AVF dysfunction varied by the site of internal jugular vein catheter placement (P for trend = 0.011). Notably, the Fine and Gray analysis confirmed the association between CAR and AVF dysfunction, with a 31% increased risk per one-unit increase in CAR. The highest CAR tertile remained an independent predictor of AVF dysfunction (HR = 1.77, 95% CI 1.21–2.58, P = 0.003). These findings highlight the potential of CAR as a prognostic marker for AVF dysfunction in Chinese HD patients. Clinicians should consider CAR levels and catheter placement site when assessing the risk of AVF dysfunction in this population.
Predicting the intention and adoption of wearable payment devices using hybrid SEM-neural network analysis
Authors: Al Mamun Abdullah , Naznen Farzana , Yang Marvello , Yang Qing , Wu Mengling , Masukujjaman Mohammad
Published: July 2023

This study aims to examine the mediating effect of the intention to use wearable payment devices (WPD) between perceived ease of use (PE), perceived usefulness (PU), social influence (SI), perceived trust (TR), and lifestyle compatibility (CM) on the adoption of WPD. Examination was made on the moderating effect of age and gender to improve the understanding of the adoption of WPD as a new payment system. Empirical data was collected through an online survey from 1094 respondents in Malaysia. Furthermore, this study employed dual-stage data analysis through partial least squares structural equation modelling (PLS-SEM) to test the causal and moderating effects, including artificial neural network (ANN) to examine the predictive power of the selected model. As a result, it was found that PE, PU, TR, and CM had a significant positive influence on the intention to use WPD. Furthermore, facilitating conditions and the intention to use WPD exhibited strong positive impacts on the adoption of WPD among Malaysian youth. The intention to use WPD positively and significantly mediated all predictors of adoption of WPD. Following that, ANN analysis confirmed high prediction accuracy of the data fitness. Overall, the findings for ANN highlighted the importance of PE, CM, and TR on the intention to adopt WPD and the impact of facilitating conditions on the adoption of WPD among Malaysian youth. Theoretically, the study extended UTAUT with two additional determinants (e.g., perceived trust and lifestyle compatibility), which were found to have significant influences on the intention to use WPD. The study results would be able to help payment service providers and the smart wearable device industry offer an innovative spectrum of products and present effective marketing tactics to encourage the prospective consumers of Wearable Payment Devices in Malaysia.
Derivation of mathematical closed form expressions for certain irregular topological indices of 2D nanotubes
Authors: Ullah Asad , Zaman Shahid , Hussain Arshad , Jabeen Asma , Belay Melaku Berhe
Published: July 2023

A numeric quantity that characterizes the whole structure of a network is called a topological index. In the studies of QSAR and QSPR, the topological indices are utilized to predict the physical features related to the bioactivities and chemical reactivity in certain networks. Materials for 2D nanotubes have extraordinary chemical, mechanical, and physical capabilities. They are extremely thin nanomaterials with excellent chemical functionality and anisotropy. Since, 2D materials have the largest surface area and are the thinnest of all known materials, they are ideal for all applications that call for intense surface interactions on a small scale. In this paper, we derived closed formulae for some important neighborhood based irregular topological indices of the 2D nanotubes. Based on the obtained numerical values, a comparative analysis of these computed indices is also performed.
Polyphosphate fertilizer impacts the enzymatic and non-enzymatic antioxidant capacity of wheat plants grown under salinity
Authors: Loudari Aicha , Latique Salma , Mayane Asmae , Colinet Gilles , Oukarroum Abdallah
Published: July 2023

By 2050, the predicted global population is set to reach 9.6 billion highlighting the urgent need to increase crop productivity to meet the growing demand for food. This is becoming increasingly challenging when soils are saline and/or deficient in phosphorus (P). The synergic effect of P deficiency and salinity causes a series of secondary stresses including oxidative stress. Reactive Oxygen Species (ROS) production and oxidative damage in plants caused either by P limitation or by salt stress may restrict the overall plant performances leading to a decline in crop yield. However, the P application in adequate forms and doses could positively impact the growth of plants and enhances their tolerance to salinity. In our investigation, we evaluated the effect of different P fertilizers forms (Ortho-A, Ortho-B and Poly-B) and increasing P rates (0, 30 and 45 ppm) on the plant's antioxidant system and P uptake of durum wheat (Karim cultivar) grown under salinity (EC = 3.003 dS/m). Our results demonstrated that salinity caused a series of variations in the antioxidant capacity of wheat plants, at both, enzymatic and non-enzymatic levels. Remarkably, a strong correlation was observed between P uptake, biomass, various antioxidant system parameters and P rates and sources. Soluble P fertilizers considerably enhanced the total plant performances under salt stress compared with control plants grown under salinity and P deficiency (C+). Indeed, salt-stressed and fertilized plants exhibited a robust antioxidant system revealed by the increase in enzymatic activities of Catalase (CAT) and Ascorbate peroxidase (APX) and a significant accumulation of Proline, total polyphenols content (TPC) and soluble sugars (SS) as well as increased biomass, Chlorophyll content (CCI), leaf protein content and P uptake compared to unfertilized plants. Compared to OrthoP fertilizers at 45 ppm P, Poly-B fertilizer showed significant positive responses at 30 ppm P where the increase reached + 18.2% in protein content, + 156.8% in shoot biomass, + 93% in CCI, + 84% in shoot P content, + 51% in CAT activity, + 79% in APX activity, + 93% in TPC and + 40% in SS compared to C+. This implies that PolyP fertilizers might be an alternative for the suitable management of phosphorus fertilization under salinity.
Cone dystrophy associated with autoimmune polyglandular syndrome type 1
Authors: Badawi Abdulrahman , Magliyah Moustafa , Alabbasi Omar , AlAbdi Lama , Alkuraya Fowzan S. , Schatz Patrik , ALBalawi Hani Basher , Mura Marco
Published: July 2023

To report the association of autoimmune polyglandular syndrome type 1 (APS1) with cone dystrophy in a large Saudi family. This is a Retrospective chart review and prospective genetic testing and ophthalmic examination of a large multiplex consanguineous family. Genetic testing was performed on 14 family members, seven of whom had detailed ophthalmic examinations. Medical history, ocular history and evaluation, visual field testing, full-field electroretinogram (ERG), and Whole Exome Sequencing (WES) results were analyzed. Three family members were homozygous for c.205_208dupCAGG;p.(Asp70Alafs*148) in AIRE and homozygous for c.481-1G>A in PDE6C. One additional family member was homozygous for only the AIRE variant and another additional family member was homozygous for only the PDE6C variant. All patients with homozygosity for the PDE6C variant had cone dystrophy, and all patients with homozygosity for the AIRE variant had APS1. In addition, two of the family members who were homozygous for the PDE6C and AIRE variants had reduced rod function on ERG. We report the co-inheritance for APS1 and PDE6C-related cone dystrophy, an unusual example of two seemingly independent recessive conditions coinciding within a family. Dual molecular diagnosis must be taken into account by ophthalmologists facing unusual constellations of findings, especially in consanguineous families.
Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets
Authors: Turpin Valentine , Schaffhauser Maud , Thabault Mathieu , Aubert Agnès , Joffre Corinne , Balado Eric , Longueville Jean-Emmanuel , Francheteau Maureen , Burucoa Christophe , Pichon Maxime , Layé Sophie , Jaber Mohamed
Published: July 2023

Dietary supplementations with n-3 polyunsaturated fatty acid (PUFA) have been explored in autism spectrum disorder (ASD) but their efficiency and potential in ameliorating cardinal symptoms of the disease remain elusive. Here, we compared a n-3 long-chain (LC) PUFA dietary supplementation (n-3 supp) obtained from fatty fish with a n-3 PUFA precursor diet (n-3 bal) obtained from plant oils in the valproic acid (VPA, 450 mg/kg at E12.5) ASD mouse model starting from embryonic life, throughout lactation and until adulthood. Maternal and offspring behaviors were investigated as well as several VPA-induced ASD biological features: cerebellar Purkinje cell (PC) number, inflammatory markers, gut microbiota, and peripheral and brain PUFA composition. Developmental milestones were delayed in the n-3 supp group compared to the n-3 bal group in both sexes. Whatever the diet, VPA-exposed offspring did not show ASD characteristic alterations in social behavior, stereotypies, PC number, or gut microbiota dysbiosis while global activity, gait, peripheral and brain PUFA levels as well as cerebellar TNF-alpha levels were differentially altered by diet and treatment according to sex. The current study provides evidence of beneficial effects of n-3 PUFA based diets, including one without LCPUFAs, on preventing several behavioral and cellular symptoms related to ASD.
Systems biology approaches to identify potential targets and inhibitors of the intestinal microbiota to treat depression
Authors: Teng Fei , Lu Zhongwen , Gao Fei , Liang Jing , Li Jiawen , Tian Xuanhe , Wang Xianshuai , Guan Haowei , Wang Jin
Published: July 2023

Depression is a common mental disease, with some patients exhibiting ideas and behaviors such as self-harm and suicide. The drugs currently used to treat depression have not achieved good results. It has been reported that metabolites produced by intestinal microbiota affect the development of depression. In this study, core targets and core compounds were screened by specific algorithms in the database, and three-dimensional structures of these compounds and proteins were simulated by molecular docking and molecular dynamics software to further study the influence of intestinal microbiota metabolites on the pathogenesis of depression. By analyzing the RMSD gyration radius and RMSF, it was finally determined that NR1H4 had the best binding effect with genistein. Finally, according to Lipinski's five rules, equol, genistein, quercetin and glycocholic acid were identified as effective drugs for the treatment of depression. In conclusion, the intestinal microbiota can affect the development of depression through the metabolites equol, genistein and quercetin, which act on the critical targets of DPP4, CYP3A4, EP300, MGAM and NR1H4.
A randomized, double-blind placebo-control study assessing the protective efficacy of an odour-based ‘push–pull’ malaria vector control strategy in reducing human-vector contact
Authors: Fillinger Ulrike , Denz Adrian , Njoroge Margaret M. , Tambwe Mohamed M. , Takken Willem , van Loon Joop J. A. , Moore Sarah J. , Saddler Adam , Chitnis Nakul , Hiscox Alexandra
Published: July 2023

Novel malaria vector control strategies targeting the odour-orientation of mosquitoes during host-seeking, such as ‘attract-and-kill’ or ‘push-and-pull’, have been suggested as complementary tools to indoor residual spraying and long-lasting insecticidal nets. These would be particularly beneficial if they can target vectors in the peri-domestic space where people are unprotected by traditional interventions. A randomized double-blind placebo-control study was implemented in western Kenya to evaluate: a ‘push’ intervention (spatial repellent) using transfluthrin-treated fabric strips positioned at open eave gaps of houses; a ‘pull’ intervention placing an odour-baited mosquito trap at a 5 m distance from a house; the combined ‘push–pull’ package; and the control where houses contained all elements but without active ingredients. Treatments were rotated through 12 houses in a randomized-block design. Outdoor biting was estimated using human landing catches, and indoor mosquito densities using light-traps. None of the interventions provided any protection from outdoor biting malaria vectors. The ‘push’ reduced indoor vector densities dominated by Anopheles funestus by around two thirds. The ‘pull’ device did not add any benefit. In the light of the high Anopheles arabiensis biting densities outdoors in the study location, the search for efficient outdoor protection and effective pull components needs to continue.
Approaching a discussion on the detachment of chlorpyrifos in contaminated water using different leaves and peels as bio adsorbents
Authors: Joshi Varsha , Jindal Manoj Kumar , Sar Santosh Kumar
Published: July 2023

The emerging contaminant chlorpyrifos, an insecticide, is generally used in agricultural fields to control termites, ants, and mosquitoes for the proper growth of feed and food crops. Chlorpyrifos reaches water sources for multiple reasons, and people who use water from nearby sources is exposed to chlorpyrifos. Due to its overuse in modern agriculture, the level of chlorpyrifos in water has drastically grown. The present study aims to address the problem arising from the utilization of chlorpyrifos-contaminated water. Natural bioadsorbents Bael, Cauliflower, Guava leaves Watermelon, and lemon peel were employed to remove chlorpyrifos from contaminated water under specific conditions of various factors, such as initial adsorbate concentration, dose of bioadsorbent, contact time, pH, and temperature. Maximum removal efficiency of 77% was obtained with lemon peel. The maximum adsorption capacity (qe) was 6.37 mg g−1. The kinetic experiments revealed that the pseudo second order model (R2 = 0.997) provided a better explanation of the mechanism of sorption. The isotherm showed that chlorpyrifos adsorbed in lemon peel in a monolayer and was best suited by the Langmuir model (R2 = 0.993). The adsorption process was exothermic and spontaneous, according to thermodynamic data.
Physics-based modeling of climate change impact on hurricane-induced coastal erosion hazards
Authors: Jamous Mohammad , Marsooli Reza , Miller Jon K.
Published: July 2023

Coastal erosion is an adverse impact of extreme water levels during major hurricanes. A warmer climate is expected to increase storm surge and wave hazards due to hurricane climatology change (HCC) and sea level rise (SLR). We conduct physics-based morphodynamic modeling to quantify the regional impacts of HCC and SLR on erosion hazards to sandy beaches and dunes along the barrier islands of New Jersey in the United States. Under the RCP8.5 scenario, we find a substantial increase in erosion hazards from the late-20th-century to late-21st-century. The regionally averaged 100-year eroded volume of beach-dune systems would increase by 58 and 84%, respectively, under the HCC and HCC + SLR scenarios. Our projections show a large spatial variability in future changes to erosion hazards, suggesting that, in addition to HCC and SLR, the morphological characteristics of beach-dune systems play an important role in the impacts of climate change on coastal erosion.
Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells
Authors: Il Ahn Jong , Zhang Liang , Ravishankar Harsha , Fan Lixin , Kirsch Klara , Zeng Yan , Meng Lingjun , Park Jung-Eun , Yun Hye-Yeoung , Ghirlando Rodolfo , Ma Buyong , Ball David , Ku Bonsu , Nussinov Ruth , Schmit Jeremy D. , Heinz William F. , Kim Seung Jun , Karpova Tatiana , Wang Yun-Xing , Lee Kyung S.
Published: July 2023

Proper organization of intracellular assemblies is fundamental for efficient promotion of biochemical processes and optimal assembly functionality. Although advances in imaging technologies have shed light on how the centrosome is organized, how its constituent proteins are coherently architected to elicit downstream events remains poorly understood. Using multidisciplinary approaches, we showed that two long coiled-coil proteins, Cep63 and Cep152, form a heterotetrameric building block that undergoes a stepwise formation into higher molecular weight complexes, ultimately generating a cylindrical architecture around a centriole. Mutants defective in Cep63•Cep152 heterotetramer formation displayed crippled pericentriolar Cep152 organization, polo-like kinase 4 (Plk4) relocalization to the procentriole assembly site, and Plk4-mediated centriole duplication. Given that the organization of pericentriolar materials (PCM) is evolutionarily conserved, this work could serve as a model for investigating the structure and function of PCM in other species, while offering a new direction in probing the organizational defects of PCM-related human diseases.
Spatially and temporally understanding dynamic solid–electrolyte interfaces in carbon dioxide electroreduction
Authors: Wang Jiali , Tan Hui-Ying , Qi Ming-Yu , Li Jing-Yu , Tang Zi-Rong , Suen Nian-Tzu , Xu Yi-Jun , Chen Hao Ming
Published: July 2023

A molecular-level picture clearly describing the dynamic interfacial interactions with their correlation to CO2RR properties is established, which enables us to spatially and temporally understand electrochemical reactions at the solid–liquid interface.
Tuning the hydraulic resistance by swelling-induced buckling of membranes in high-aspect-ratio microfluidic devices
Authors: Stamp Claas-Hendrik , Solomon Binyam , Lang Friederike , Mitropoulos Efstathios , Pfohl Thomas
Published: July 2023

Using swelling-induced buckling of thin membranes as controlling and adapting elements for pressure-driven flows in microfluidic devices.
ITIH5, as a predictor of prognosis and immunotherapy response for P53-like bladder cancer, is related to cell proliferation and invasion
Authors: Peng Kun , Ding Degang , Wang Ning , Du Tao , Wang Lingdian , Duan Xiaoyu
Published: July 2023

The study design and flowchart of this work. BLCA, bladder cancer. IPS, immunophenoscores.
Weakly supervised anomaly detection coupled with Fourier transform infrared (FT-IR) spectroscopy for the identification of non-normal tissue
Authors: Ferguson Dougal , Henderson Alex , McInnes Elizabeth F. , Gardner Peter
Published: July 2023

A novel weakly supervised anomaly detection machine learning method is used to identify non-normal tissue subgroups, interferents, and other tissue components in IR Micro-spectroscopy liver tissue data when trained on a single control group of data.
Feasibility of Raman spectroscopic identification of gall bladder cancer using extracellular vesicles extracted from bile
Authors: Bui Thu Thuy , Jang Eunjin , Shin Ji Hyun , Kim Tae Hun , Kim Hayoon , Choi Dongho , Vu Tung Duy , Chung Hoeil
Published: July 2023

Extracellular vesicles (EVs) extracted from human bile could be versatile biomarkers for the identification of gall bladder cancer.
Tuning ice nucleation with pH-modulated Fe3+ cross-linked hydrogel surfaces
Authors: Meng Xiao , Diao Yunhe , Zhu Ranran , Zhang Fan , Liu Xuying , Chen Jinzhou , Yang Huige
Published: July 2023

Fe3+-Catechol coordination cross-linked hydrogels are constructed to mediate ice nucleation by changing the degree of cross-linking through pH modulation.
Supramolecular self-assembled polymeric nanospheres based on hydrazino naphthalimide functionalised pillar[5]arene for long chain aldehyde detection
Authors: Sanguansap Yanisa , Ruangpornvisuti Vithaya , Atithep Thassanant , Bunchuay Thanthapatra , Tomapatanaget Boosayarat
Published: July 2023

A novel fluorescent sensor composed of bis-hydrazino naphthalimide decorated with a pillar[5]arene motif demonstrated highly selective fluorescent sensing of nonanal and octanalviaself-assembled supramolecular polymeric nanoparticles.
Unravelling the pseudocapacitive origin of graphene oxide-based aerogels by comparative insights
Authors: Huang Tieqi , Wu Weiying , Yang Zhengfei , Hou Qianqian , Li Ruolan , Chen Suyue , Yang Yahui , Liu Hongtao
Published: July 2023

We reveal the intrinsic pseudocapacitive center of graphene-oxide-based aerogels by investigating different modified graphene skeletons from various approaches.
NHC stabilized copper nanoparticlesviareduction of a copper NHC complex
Authors: Richstein Robert , Eisen Constantin , Ge Lingcong , Chalermnon Monnaya , Mayer Florian , Keppler Bernhard K. , Chin Jia Min , Reithofer Michael R.
Published: July 2023

NHC@CuNPs are bottom-up synthesized using NHCCuX as a precursor. Detailed NHC-binding and stability studies of the NHC@CuNPs show that they behave differently to typical NHC@Cu surface, which is important for development of new CuNP catalysts.
Ideal topological Weyl complex phonons in two dimensions
Authors: Yu Wei-Wang , Liu Ying , He Zeqing , Wang Lirong , Zhang Xiaoming , Liu Guodong
Published: July 2023

We propose an approach that enforces an ideal Weyl complex in 2D spinless systems.
Investigating the Al/Si mixed site occupancy in the β-AlFeSi phase
Authors: Lafaye Paul , Vo Minh Duc , Jofre Javier , Harvey Jean-Philippe
Published: July 2023

Crystal chemistry of the β-AlFeSi phase from DFT and QHA calculations together with thermodynamic modelling.
A first-principles study of the structural, electronic and elastic properties of the FeO2–FeO2He system under high pressure
Authors: Liu Haibo , Liu Lei , Xin Cunlin , Yang Longxing , Gu Xiaoyu
Published: July 2023

The effect of pressure on the electrical properties of FeO2–FeO2He is studied, and its structural and elastic properties reveal a deep primordial helium reservoir and candidate for seismic velocity anomalies at the core–mantle boundary.
Multistructural partition function truncation and its effect on the thermal rate constants
Authors: Nascimento Joel Leitão , Passos Maiara Oliveira , Alves Tiago Vinicius
Published: July 2023

Thermal rate constants for the hydrogen abstraction reaction of methyl pentanoate were calculated using the multistructural canonical variational theory with small-curvature tunneling (MS-CVT/SCT).
Thermosalient effect of a naphthalene diimide and tetrachlorocobaltate hybrid and changes of color and magnetic properties by ammonia vapor
Authors: Masuda Shunya , Kusumoto Sotaro , Okamura Masaya , Hikichi Shiro , Tokunaga Ryuya , Hayami Shinya , Kim Yang , Koide Yoshihiro
Published: July 2023

An NDI-based Co(ii)-OIMH represents a new combination of functional materials, demonstrating both thermosalient effects in the solid state and sensing abilities for ammonia through changes in color and magnetism.
Anion-directed structural tuning of two azomethine-derived Zn2+ complexes with optoelectronic recognition of Cu2+ in aqueous medium with anti-cancer activities: from micromolar to femtomolar sensitivity with DFT revelation
Authors: Pandit Nithun Ranjan , Bej Sourav , Das Riyanka , Ghosal Nirajan , Mondal Ananya , Pal Ranjana , Ghosh Meenakshi , Banerjee Priyabrata , Biswas Biplab
Published: July 2023

Herein, two novel mononuclear transition metal Zn2+ complexes  have been synthesised using a tridentate clickable Schiff base ligand, HL (2-methyl-2-((pyridin-2-ylmethyl)amino)propan-1-ol) and the polyatomic monoanions N3− and ClO4−.
A portable sensor for the determination of tree canopy air quality
Authors: Berelson William , Rollins Nick , Kim Jinsol , Johnson Emma , Margulies Esther , Casas Naman , MacDonald Beau , Wilson John
Published: July 2023

A low-cost portable sensor system has been developed and described to interrogate individual trees and quantify their impact on air quality (CO, NO2, PM2.5).
Photocatalytic and photoelectrocatalytic degradation of perfluorooctanoic acid by immobilised ZnO nanoparticles using electrophoretic deposition
Authors: Navidpour Amir Hossein , Safaei Javad , Zhang Guojin , Mojiri Amin , Ni Bing-Jie , Huang Zhenguo , Zhou John L.
Published: July 2023

This research represents the first study of perfluorooctanoic acid (PFOA) decomposition using immobilized ZnO nanoparticles by electrophoretic deposition in photocatalysis and photoelectrocatalysis.
Effect of alkali-metal cation on oxygen adsorption at Pt single-crystal electrodes in non-aqueous electrolytes
Authors: Fernández-Vidal Julia , Hardwick Laurence J. , Cabello Gema , Attard Gary A.
Published: July 2023

The effect of Group 1 alkali-metal cations (Na+, K+, and Cs+) on the oxygen reduction and evolution reactions (ORR and OER) using dimethyl sulfoxide (DMSO)-based electrolytes was investigated.
Novel biphasic DES/GVL solvent for effective biomass fractionation and valorization
Authors: Cheng Jinyuan , Liu Xuze , Huang Chen , Zhan Yunni , Huang Caoxing , Chen Tingjun , Meng Xianzhi , Yoo Chang Geun , Fang Guigan , Ragauskas Arthur J.
Published: July 2023

All the bamboo fractions can be utilized using the biphasic DES/GVL system.
Electrochemical transformation ofd,l-glutamic acid into acrylonitrile
Authors: Kümper Justus , Meyers Jérôme , Sebers Rebecca , Kurig Nils , Palkovits Regina
Published: July 2023

We present a new route for the electrochemical synthesis of green acrylonitrile using the biogenic amino acidd,l-glutamic acid as a substrate by utilising electro-oxidative decarboxylation and non-Kolbe electrolysis.
Limonene as a natural product extraction solvent
Authors: Pagliaro Mario , Fabiano-Tixier Anne-Sylvie , Ciriminna Rosaria
Published: July 2023

The use of natural product limonene as natural product extraction solvent offers multiple benefits that go beyond its environmentally benign nature.
Catching up on calibration-free LIBS
Authors: Poggialini Francesco , Campanella Beatrice , Cocciaro Bruno , Lorenzetti Giulia , Palleschi Vincenzo , Legnaioli Stefano
Published: July 2023

This review paper will present and critically discuss the evolution of the calibration-free LIBS (CF-LIBS) method and some of its new applications that appeared since the last extensive review on the topic, which was published more than 10 years ago.
Optimization of the 2-arylquinazoline-4(3H)one scaffold for a selective and potent antitrypanosomal agent: modulation of the mechanism of action through chemical functionalization
Authors: Romero Angel H. , Aguilera Elena , Gotopo Lourdes , Cabrera Gustavo , Dávila Belén , Cerecetto Hugo
Published: July 2023

We identified a potent and selective antitrypanosomal agent through modulation of the mechanism of action of a 2-arylquinazoline scaffold as an antitrypanosomal agent via chemical functionalization at the 4-position.
Self-assembly of Schiff base anions and the trapping of HO−, O2− and Piv− bridges in a family of Ni3Ln4 complexes: synthesis, structures and magnetic properties
Authors: Biswas Mousumi , Mavromagoulos Athanasios , Murrie Mark , Ray Debashis
Published: July 2023

Pentadentate Schiff base ligands bind three NiII–LnIII centres in cyclic order to yield a unique family of propeller-shaped heptanuclear Ni3Ln4 coordination aggregates which show overall antiferromagnetic interactions between the NiII and LnIII ions.
Copper phosphide–phosphorus (Cu3P/P) hybrid nanomaterials: an in situ dioxygen activator in ambient aqueous conditions for advanced oxidation process
Authors: Hu Jiaojiao , Deng Guoxi , Ru Jiayi , Chen Xiaodan
Published: July 2023

The green synthesis of copper phosphide–phosphorus (Cu3P/P) hybrid nanomaterials was achieved, and they exhibit remarkably high degradation activity for SMX via the spontaneous generation of ROS.
Effect of terminal groups on the degradation stability of Ti3C2Tz MXenes
Authors: Athavale Swarnima , Micci-Barreca Stefano A. , Arole Kailash , Kotasthane Vrushali , Lutkenhaus Jodie L. , Radovic Miladin , Green Micah J.
Published: July 2023

We use –Br and –Cl as model terminal groups to compare the degradation stability of MXenes.
A review on the application of molecular descriptors and machine learning in polymer design
Authors: Zhao Yuankai , Mulder Roger J. , Houshyar Shadi , Le Tu C.
Published: July 2023

Molecular descriptors and machine learning are useful tools for extracting structure–property relationships from large, complex polymer data, and accelerating the design of novel polymers with tailored functionalities.
Phase engineering of iron group transition metal selenides for water splitting
Authors: Cao Wenwen , Shen Qi , Men Dandan , Ouyang Bo , Sun Yiqiang , Xu Kun
Published: July 2023

This review summarizes the phase engineering of iron group transition metal selenides, which have excellent catalytic properties and remarkable economic benefits for both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER).
The BC bond: some recent developments
Authors: Chen Chaohuang , Kehr Gerald , Erker Gerhard
Published: July 2023

The facile deprotonation of fluoroaryl-substituted alkylboranes or alkylboron cations readily leads to anionic boratalkenes or neutral boraalkenes, respectively. These BC double bond systems exhibit an increasing variety of chemical reactivities.
SO2ClF-promoted chlorination-oxidation of 2-methylindoles: a one-step synthetic method to access 2,3-difunctionalized indoles
Authors: Zheng Yu , Ma Tianting , Liu Bingcong , Huang Shenlin
Published: July 2023

We developed a convenient and one-step methodology for the synthesis of 3-chloro-2-formylindoles from readily available 2-methylindoles and SO2ClF.
Biomimetic-inspired synthesis of sporochartines through Diels–Alder reaction between enantiopure (−)-sporothriolide and (+)-trienylfuranol A
Authors: Arcile Guillaume , Massard Théo , van Elslande Elsa , Ouazzani Jamal , Betzer Jean-François
Published: July 2023

A reaction between synthesized enantiopure (+)-trienylfuranol A and cultivated (−)-sporothriolide allowed us to confirm that the spiranic backbones of sporochartines are formed by a [4 + 2] cycloaddition reaction.
The synthesis and super capacitive characterization of microwave-assisted highly crystalline α-Fe2O3/Fe3O4 nanoheterostructures
Authors: Panmand Rajendra , Sethi Yogesh , Jha Animesh , Kale Bharat
Published: July 2023

In this work, the synthesis of α-Fe2O3/Fe3O4 nanoheterostructures by controlling the solvent concentration. Further, the electrochemical properties of α-Fe2O3/Fe3O4, nanoparticles were investigated with charge–discharge and CV measurements.
Impact of crystal structure on optical properties and temperature sensing behavior of NaYF4:Yb3+/Er3+ nanoparticles
Authors: Dubey Charu , Yadav Anjana , Baloni Diksha , Kachhap Santosh , Singh Sunil Kumar , Singh Akhilesh Kumar
Published: July 2023

We report a comprehensive study of the structural, morphological, and optical properties, and UC-based ratiometric temperature sensing behavior of (α) cubic and (β) hexagonal phases of NaYF4:Yb3+/Er3+ nanoparticles.
Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for h-NTPDases
Authors: Zaigham Zahid Hussain , Ullah Saif , Pelletier Julie , Sévigny Jean , Iqbal Jamshed , Hassan Abbas
Published: July 2023

Sulfamoyl-benzamides were found to be selective inhibitors against h-NTPDases1, -2, -3, and -8 in sub-micromolar concentration, for instance, compound 3i was found to be the most potent inhibitor of h-NTPDase1 (IC50 = 2.88 ± 0.13 μM).
Surfactant assisted exfoliation of near infrared fluorescent silicate nanosheets
Authors: Hill Bjoern , Abraham Smitha , Akhtar Anas , Selvaggio Gabriele , Tschulik Kristina , Kruss Sebastian
Published: July 2023

Egyptian blue (CaCuSi4O10) is exfoliated into 2D nanosheets of high monodispersity down to monolayers by a mild surfactant-assisted procedure. These nanosheets are fluorescent in the near infrared (NIR) and useful for (bio)photonics.
Efficient neural network models of chemical kinetics using a latent asinh rate transformation
Authors: Döppel Felix A. , Votsmeier Martin
Published: July 2023

The proposed latent transformation approach allows building lightweight neural networks that accelerate reactor simulations significantly.
Antibiotic residue derived solid acids for ethanolysis of furfuryl alcohol into ethyl levulinate
Authors: Yuan Haoran , Li Chengyu , Shan Rui , Zhang Jun , Chen Yong
Published: July 2023

Antibiotic residue derived carbon-based solid acids were developed for the ethanolysis of furfuryl alcohol into ethyl levulinate, which highlighted a novel direction for the synthesis of value-added chemicals over organic waste derived materials.
Enhancement of formic acid formation by nitrogen-doped graphene oxide nanosheets decorated with Sn nanoparticles in electrochemical CO2 reduction
Authors: Tano Yuma , Ahmad Muhammad Sohail , Watase Yuya , Tsugawa Tatsuki , Takase Satoko , Inomata Yusuke , Hatakeyama Kazuto , Ida Shintaro , Armando Quitain , Shimizu Youichi , Kida Tetsuya
Published: July 2023

Electrochemical conversion of CO2 into renewable fuels is a critical area of research that poses significant scientific challenges.
Sustainable design of water–energy–food nexus: a literature review
Authors: Segovia-Hernández Juan Gabriel , Contreras-Zarazúa Gabriel , Ramírez-Márquez César
Published: July 2023

The water–energy–food nexus aims to achieve sustainable development by meeting present needs while safeguarding the capacity of future generations.
Underlying potential evaluation of the real-process applications of magnetic porous liquids
Authors: Mahdavi Hamidreza , Sadiq Muhammad M. , Smith Stefan J. D. , Mulet Xavier , Hill Matthew R.
Published: July 2023

Magnetic porous liquids offer the potential to combine the sorption capacity of porous solids with the processibility of liquids.
An integrated approach for preventing hydrogen leakage from metallic vessels: barrier and scavenging
Authors: Luzzatto Yonatan , Alatawna Amer , Peretz Eli , Mendelson Orit , Pevzner Svetlana , Regev Oren
Published: July 2023

Hydrogen leaks from pipes can be reduced using either a graphene-loaded composite coating that creates a tortuous path for hydrogen molecules, or a composite coating loaded with unsaturated organic molecules that react with and prevent hydrogen leakage.
Maximizing the performance of protein-based fluorescent biosensors
Authors: Chai Fu , Cheng Dazhou , Nasu Yusuke , Terai Takuya , Campbell Robert E.
Published: July 2023

Fluorescent protein (FP)-based biosensors are genetically encoded tools that enable the imaging of biological processes in the context of cells, tissues, or live animals. Though widely used in biological research, practically all existing biosensors are far from ideal in terms of their performance, properties, and applicability for multiplexed imaging. These limitations have inspired researchers to explore an increasing number of innovative and creative ways to improve and maximize biosensor performance. Such strategies include new molecular biology methods to develop promising biosensor prototypes, high throughput microfluidics-based directed evolution screening strategies, and improved ways to perform multiplexed imaging. Yet another approach is to effectively replace components of biosensors with self-labeling proteins, such as HaloTag, that enable the biocompatible incorporation of synthetic fluorophores or other ligands in cells or tissues. This mini-review will summarize and highlight recent innovations and strategies for enhancing the performance of FP-based biosensors for multiplexed imaging to advance the frontiers of research.
Structural insights into NMDA receptor pharmacology
Authors: Zhou Changping , Tajima Nami
Published: July 2023

N-methyl-d-aspartate receptors (NMDARs) comprise a subfamily of ionotropic glutamate receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles in neuronal processes such as synaptic signaling and plasticity. Given their critical roles in brain function and their therapeutic importance, enormous research efforts have been devoted to elucidating the structure and function of these receptors and developing novel therapeutics. Recent studies have resolved the structures of NMDARs in multiple functional states, and have revealed the detailed gating mechanism, which was found to be distinct from that of other ionotropic glutamate receptors. This review provides a brief overview of the recent progress in understanding the structures of NMDARs and the mechanisms underlying their function, focusing on subtype-specific, ligand-induced conformational dynamics.