bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of donor and recipient MDR1 G2677TA, C1236T, C3435T match and mismatch on the outcomes of patients after allogeneic hematopoietic stem cell transplantation
Authors: Duan Ziwen , Zhang Xiao , Liu Yanping , Wang Jiawen , Zhu Han , Chen Ruize , Xu Wei , Miao Kourong
Published: March 2024

In this study, we investigated whether the matched or mismatched multidrug resistance (MDR1) G2677TA, C1236T and C3435T were associated with prognosis in patients after allo-HSCT. One hundred patients after transplantation and their donors were enrolled. We tested all enrollers for genotypes at the following three loci: G2677TA, C1236T and C3435T. Matched MDR1 G2677TA donor-recipient was associated with an increased risk of non-relapse mortality (NRM) (29.5% vs. 6.2%, p = 0.002), and poor overall survival (OS) (51.7% vs. 63.8%, p = 0.024) and disease-free survival (DFS) (38.6% vs. 67%, p = 0.005). There were no differences in OS, DFS, NRM between MDR1 C1236T, C3435T matched and mismatched group. Subgroup analysis suggested that in matched MDR1 G2677TA group, male (OS, 31.3% vs. 76.9%, p = 0.011; DFS, 25% vs. 55.6%, p = 0.027), hematopoietic cell transplantation–specific comorbidity index (HCT-CI) ≥ 1 (OS, 16.7% vs. 60.9%, p = 0.007; DFS, 16.7 vs. 44.4%, p = 0.017), acute kidney injury (AKI) patients with serum creatinine > 137.2umol/L (OS, 12.5% vs. 80%, p = 0.047; DFS, 0 vs. 60%, p = 0.017), and post-transplantation thrombocytopenia (PT) (OS, 33.3% vs. 71.4%, p = 0.030; DFS, 21.4% vs. 55.1%, p = 0.018 ) had poor survival. Results demonstrated that prognosis of matched MDR1 G2677TA donor-recipient was worse than mismatched. It may become a useful molecular tool to identify the poor prognosis of patients after transplantation.
Exploring the Role of Campus Clubs in Fostering Sustainable Development of Traditional Chinese Stone Rubbing Artistry: A Case Study of Nanjing Forestry University
Authors: Tao Haomiao , Lu Huangjia , Zhu Ping
Published: March 2024

Traditional Chinese stone rubbing artistry is an ancient Chinese art that involves the technique of tightly covering paper on the surface of metal, stone, and other hard objects, and transferring the objects’ graphics, decorations, inscriptions, and so on to paper with ink or oil colors. Traditional Chinese stone rubbing artistry is a unique discipline that integrates epigraphy, calligraphy, and painting and is widely used in archaeology, literature, and art. With the passage of time, it is now on the verge of being in the lost-and-listed category of intangible cultural heritage projects in Nanjing. Hence, revitalizing this ancient art form of traditional Chinese stone rubbing artistry has become a realistic problem. This study explores a new path for the sustainable development of traditional Chinese stone rubbing artistry with the intervention of campus art clubs and a combination of digital platforms. Taking the first practice of the Nanjing Forestry University’s Traditional Chinese Stone Rubbing Artistry Club as an example, this study explores the “five-in-one” inheritance model of traditional Chinese stone rubbing artistry represented by the master-apprentice system by adopting research methods such as literature analysis and expert interviews.
Elevated soluble CD226 in Takayasu arteritis is useful for differentiation from giant cell arteritis and is associated with the disease activity and prognosis
Authors: Nakano Miki , Ayano Masahiro , Fukui Shoichi , Iwanaga Nozomi , Tatsutani Tomofumi , Takaki-Kuwahara Ayako , Kimoto Yasutaka , Akahoshi Mitsuteru , Migita Kiyoshi , Kawakami Atsushi , Tada Yoshifumi , Niiro Hiroaki
Published: March 2024

Background
Takayasu arteritis (TAK) is characterized by vascular injury, in which endothelial cells and immune cells, such as natural killer (NK) cells, have key roles. CD226 is an activating receptor expressed on the cell membrane of NK cells and T cells, and the soluble form of CD226 (sCD226) is increased in diseases involving these cells. Therefore, we investigated the utility of serum sCD226 as a biomarker for TAK.
Methods
Serum sCD226 levels were measured using an enzyme-linked immunosorbent assay in 34 patients with TAK and 21 patients with giant cell arteritis (GCA). The associations between sCD226 levels and the angiographic classification, disease activity, and prognosis of TAK were analysed.
Results
Serum sCD226 levels were significantly higher in TAK patients than in GCA patients. In patients with TAK, serum sCD226 levels were significantly elevated in the group of type Ⅴ, which had the most extensive lesions, compared with the group of other types excluding type Ⅴ. Serum sCD226 levels were also elevated in patients with active TAK and in those with poor responses to corticosteroids. Regarding prognosis, the cumulative probability of relapse was higher in patients with high sCD226 levels than in those with low sCD226 levels.
Conclusions
Serum sCD226 levels differentiated TAK from GCA and were associated with disease activity and relapse of TAK. Serum sCD226 may be a useful biomarker for the management of TAK.
Long term follow-up of patients with newly diagnosed glioblastoma treated by intraoperative photodynamic therapy: an update from the INDYGO trial (NCT03048240)
Authors: Peciu-Florianu Iulia , Vannod-Michel Quentin , Vauleon Enora , Bonneterre Marie-Edith , Reyns Nicolas
Published: March 2024

Purpose
Glioblastoma remains incurable despite optimal multimodal management. The interim analysis of open label, single arm INDYGO pilot trial showed actuarial 12-months progression-free survival (PFS) of 60% (median 17.1 months), actuarial 12-months overall survival (OS) of 80% (median 23.1 months). We report updated, exploratory analyses of OS, PFS, and health-related quality of life (HRQOL) for patients receiving intraoperative photodynamic therapy (PDT) with 5-aminolevulinic acid hydrochloride (5-ALA HCl).
Methods
Ten patients were included (May 2017 – April 2021) for standardized therapeutic approach including 5-ALA HCl fluorescence-guided surgery (FGS), followed by intraoperative PDT with a single 200 J/cm2 dose of light. Postoperatively, patients received adjuvant therapy (Stupp protocol) then followed every 3 months (clinical and cerebral MRI) and until disease progression and/or death. Procedure safety and toxicity occurring during the first four weeks after PDT were assessed. Data concerning relapse, HRQOL and survival were prospectively collected and analysed.
Results
At the cut-off date (i.e., November 1st 2023), median follow-up was 23 months (9,7–71,4). No unacceptable or unexpected toxicities and no treatment-related deaths occurred during the study. Kaplan-Meier estimated 23.4 months median OS, actuarial 12-month PFS rate 60%, actuarial 12-month, 24-month, and 5-year OS rates 80%, 50% and 40%, respectively. Four patients were still alive (1 patient free of recurrence).
Conclusion
At 5 years-follow-up, intraoperative PDT with surgical maximal excision as initial therapy and standard adjuvant treatment suggests an increase of time to recurrence and overall survival in a high proportion of patients. Quality of life was maintained without any severe side effects.
Unfolded proteins in the mitochondria activate HRI and shut-down of mitochondrial protein translation
Authors: Wu Yongshu , Yang Yang , Qin Xiaodong , Zhang Zhixiong , Ullah Munib , Li Yanmin , Zhang Zhidong
Published: March 2024

Mitochondrial unfolded protein response (UPRmt) is triggered through eIF2α phosphorylation in mammal. However, the mechanisms of UPRmt activation and the influence on mitochondrial protein translation through eIF2α phosphorylation remain unclear. In this study, we confirmed that UPRmt was a rapid and specific stress response through eIF2α phosphorylation with pharmacological induction, along with the protein expression of eIF2α phosphorylation, ATF4, and CHOP. Meanwhile, with the up-regulation of some chaperones, cytochrome P450 enzymes, and DDIT4 determined by RNA-Seq and ribosome profiling, eIF2α phosphorylation is essential for expressing ATF4 and CHOP, then ATF4 traffics into the nucleus and initiates CHOP expression. In addition, the generation of ROS and mitochondrial morphology was unchanged under GTPP induced UPRmt. Furthermore, we unraveled the mechanism that HRI kinase mediates UPRmt induced with mitochondrial unfolded proteins by CRISPR-Cas9 technology and mitochondrial recruitment of HRI and interaction with other proteins. Meanwhile, we confirmed that mitochondrial protein translation and the number of mitochondrial protein imports were inhibited through eIF2α phosphorylation with the accumulation of mitochondrial unfolded protein. These findings provide the molecular mechanism of UPRmt and the impact on cellular protein translation, which will offer a novel insights into the functional research of UPRmt, including its implications for human diseases and pathobiology.
Enhancing the efficiency of open quantum batteries via adjusting the classical driving field
Authors: Hadipour Maryam , Haseli Soroush
Published: March 2024

In the context of quantum information, a quantum battery refers to a system composed of quantum particles that can store and release energy in a way that is governed by the principles of quantum mechanics. The study of open quantum batteries is motivated by the fact that real-world quantum systems are almost never perfectly isolated from their environment. One important challenge in the study of open quantum batteries is to develop theoretical models that accurately capture the complex interactions between the battery and its environment. the goal of studying open quantum batteries is to develop practical methods for building and operating quantum devices that can store and release energy with high efficiency and reliability, even in the presence of environmental noise and other sources of decoherence. The charging process of open quantum batteries under the influence of dissipative environment will be studied. In this Work, the effect of the classical driving field on the charging process of open quantum batteries will be investigated. The classical driving field can be used to manipulate the charging and discharging process of the battery, leading to enhanced performance and improved efficiency. It also will be showed that the efficiency of open quantum batteries depends on detuning between the qubit and the classical driving field and central frequency of the cavity and the classical driving field.
Economic Indicator-Based Power Quality Assessment of Distribution Network Incorporating Electric Vehicle Stations
Authors: Shi Shuaibin , Liu Yongli , Wang Qing , Cen Baoyi
Published: March 2024

The access of electric vehicle charging stations (EVCS) brings challenges to the stable operation of the distribution network.At present, there is a lack of indicator to quantify the economic losses caused by the decrease in power quality of the distribution network due to the access of EVCSs.In the paper, the travel trajectories of electric vehicle users are constructed through trip chain and state transition matrices,thereby obtaining the spatiotemporal distribution of charging loads.In addition, the voltage deviation and line loss caused by charging loads are unified into economic indicator to quantify.The simulations are conducted in a road network coupled to the IEEE 33-node distribution network.The result shows that the charging load of electric vehicle charging stations have a significant impact on the power quality of the distribution network.At the same time, optimizing the location of charging stations and guiding electric vehicle users’ charging behaviorcan effectively improve the power quality and economic efficiency of distribution networks.
Surfactant-tolerant Cathodes for Electrochemical Generation of Hydrogen Peroxide for Wastewater Treatment
Authors: Malevich Dzmitry , Mypati Sreeman , Ray Sreemoyee Ghosh , Dinh Cao-Thang , Barz Dominik P.J.
Published: March 2024

Cathode materials based on carbon substrates are of high interest for the electrochemical generation of hydrogen peroxide (H2O2) for wastewater treatment because of their low cost, chemical stability and high selectivity. However, the H2O2 selectivity of carbon materials can be significantly reduced in presence of surfactants, which are frequent contaminants in wastewater. Therefore, the development of surfactant-tolerant cathode materials is highly important. In this paper, composite electrodes comprising of polytetrafluoroethylene and carbon black on a carbon felt substrate were prepared. The effect of sodium dodecyl sulphate on the electrode activity was investigated. It was found that the electrodes prepared with high bulk density carbon black featured a high H2O2 Faradaic efficiency of 95% in surfactant-free solutions. These electrodes also showed significant surfactant tolerance having a 70% Faradaic efficiency in the presence of 1mM sodium dodecyl sulphate. The enhanced surfactant tolerance is attributed to the hydrophobic properties of the electrode surface.
Integrating remote sensing and field measurement data to estimate rain-fed chickpea yield
Authors: Momenpour Seyed Erfan , Bazgeer Saeed , Moghbel Masoumeh
Published: March 2024

Prior studies evidenced that crop yield prediction was mostly focused on cereals, including wheat, corn and rice. However, combining the use of field and satellite data to build regression models to predict chickpea yield has not been studied. This study aims to estimate rain-fed chickpea yield using field-measured data and remote sensing vegetation indices in Kermanshah County, the most productive chickpea region, in Iran. The ground data were collected from 14 fields near the rain gauge stations in 2022. The in-situ data measured include soil moisture, soil texture, and leaf area index (LAI). In addition, the remotely-sensed based indices, including Normalized Difference Vegetation Index (NDVI), Soil Adjusted Vegetation Index (SAVI), and Temperature Vegetation Dryness Index (TVDI) acquired from Landsat 8 and 9 satellites were employed to integrate into the regression models. The most optimal model was determined by applying the Bayes Information criterion (BIC), Mallows’ Cp, LASSO and Elastic Net Regression. The results indicated that the regression model based on the BIC and Cp statistics, incorporating two predictor variables, LAI and soil sand percentage, is the optimal model from the emergence to flowering stage. This model accurately predicted 87% of the variation in chickpea yield during testing, with RMSE = 46.4 kg.ha− 1 and MAE = 40.4 kg.ha− 1. The results revealed that the Bic and Cp can be employed to select the most accurate model with the smallest error for estimating the rain-fed chickpea yield. In addition, Agricultural import and export officials can utilize this simplistic model for planning purposes.
A case of blurry vision, headache and dizziness manifested as hypertensive retinopathy with papilledema in a patient with a recent diagnosis of peritoneal tuberculosis
Authors: Siraj Hashim Mohamed
Published: March 2024

Hypertension poses significant risks to various organ systems, including the eyes, leading to target-organ damage known as hypertensive retinopathy (HR). This case report explores the case of a 60-year-old male presenting with blurred vision, headache, and dizziness, ultimately diagnosed with grade IV hypertensive retinopathy. The patient had a complex medical history including hypertension, dyslipidemia, ischemic heart disease, diabetes mellitus, and peritoneal tuberculosis, with recent initiation of anti-tuberculosis therapy. Differential diagnoses encompassed various ocular and systemic conditions, highlighting the importance of a thorough evaluation. Fundoscopic examination revealed bilateral papilledema and flame hemorrhages consistent with hypertensive retinopathy. Management involved meticulous blood pressure control and ophthalmological referral. Collaboration between healthcare providers facilitated comprehensive care. Following treatment, the patient's blood pressure improved, necessitating adjustments in antihypertensive medications. This case underscores the critical role of recognizing ocular manifestations in hypertensive patients and the need for interdisciplinary management to mitigate systemic morbidity and mortality. Ongoing research is crucial to enhance diagnostic and therapeutic strategies for hypertensive retinopathy, ensuring optimal patient outcomes.
Developing Bullying Prevention Guidelines for Nurse Interns and its Effects on Their Assertiveness
Authors: yazied Lobna S. Abou El , Hassan Rabab M. , Badran Fawzia M.
Published: March 2024

Background
Bullying is a serious problem which had short and long term negative consequences on nurse interns behaviors. Bullying prevention guidelines have a great impact on reducing exposure to the bullying incidence among nurse interns.
Aim
The present study aimed to assess evaluate the effect of developing bullying prevention guidelines on nurse interns assertiveness level.
Methods
A methodological study design was used to conduct the study at Ain Shams University Hospitals in Cairo Governorate, Egypt. The study subjects were consisted of a purposive sample of 121 nurse interns. Data were collected using four tools; Bullying Knowledge Questionnaire, Negative act questionnaire [NAQ], Individual Bullying Behaviors In Clinical Practice Survey, and Assertiveness Inventory. Data analysis was performed using SPSS version 24, Qualitative categorical variables were compared using the chi-square test. A significant level value was considered when the p-value ≤ 0.01, and multivariate analysis, demonstrates statistically significant predictor of the score.
Results
Scores of bullying and assertiveness after implementation of the prevention guidelines were significantly improved among nurse interns 91.4%, 86.3% incidence of exposure to bullying compared with pre-test scores with 34.7, 11.8 [P < 0.001].
Conclusion
The bullying prevention guidelines was significantly reduce nurse interns bullying and improve their assertiveness. The study recommended dissemination and generalization of the developed bullying prevention guidelines at the different training settings.
Trial Registration Number [TRN]
The study protocol was approved by the Research Ethics Committee of the Faculty of Nursing, Ain Shams University (code number: NUR 23.9.128).
Self-reports map the landscape of task states derived from brain imaging
Authors: Mckeown Bronte , Goodall-Halliwell Ian , Wallace Raven , Chitiz Louis , Mulholland Bridget , Karapanagiotidis Theodoros , Hardikar Samyogita , Strawson Will , Turnbull Adam , Vanderwal Tamara , Ho Nerissa , Wang Hao-Ting , Xu Ting , Milham Michael , Wang Xiuyi , Zhang Meichao , Alam Tirso Gonzalez , de Wael Reinder Vos , Bernhardt Boris , Margulies Daniel , Wammes Jeffrey , Jefferies Elisabeth , Leech Robert , Smallwood Jonathan
Published: March 2024

Psychological states influence our happiness and productivity; however, estimates of their impact have historically been assumed to be limited by the accuracy with which introspection can quantify them. Over the last two decades, studies have shown that introspective descriptions of psychological states correlate with objective indicators of cognition, including task performance and metrics of brain function, using techniques like functional magnetic resonance imaging (fMRI). Such evidence suggests it may be possible to quantify the mapping between self-reports of experience and ‘ground-truth’ or biologically related representations of those states (e.g., those inferred from measures of brain activity). Here, we used machine learning to show that self-reported descriptions of experiences across tasks can reliably map the objective landscape of task states derived from brain activity. In our study, participants provided descriptions of their psychological states while performing tasks for which the contribution of different brain systems was available from prior fMRI studies. We used machine learning to combine these reports with descriptions of brain function to form a ‘state-space’ that reliably predicted patterns of brain activity based solely on unseen descriptions of experience. Our study demonstrates that introspection contains information that maps the objective task landscape inferred from brain activity.
La competencia digital de estudiantes y docentes en los centros de educación secundaria
Authors: Verdú-Pina María , Grimalt-Álvaro Carme , Usart Mireia , Gisbert-Cervera Mercè
Published: March 2024

El desarrollo de la competencia digital de estudiantes y docentes es un aspecto clave en todas las etapas educativas. Es necesario tener un diagnóstico de ambas competencias con el fin de detectar posibles brechas y desigualdades y diseñar acciones formativas adecuadas basadas en las necesidades reales. El objetivo de este estudio es realizar un diagnóstico del nivel de competencia digital de estudiantes y docentes en 14 centros de educación secundaria y bachillerato en Cataluña. Los resultados muestran que el alumnado se autopercibe con un nivel medio-alto de competencia digital, mientras que el profesorado lo hace con un nivel experto de competencia digital docente. Asimismo, se encontraron diferencias significativas en el nivel de competencia digital docente en función del género y la edad, y en la competencia digital del alumnado en función del curso y de la repetición de curso. Los resultados sugieren una evidente necesidad de formación del profesorado y alumnado con el objetivo de mejorar estas competencias y reducir desigualdades respecto a género, edad, nivel educativo y rendimiento académico.
Funcionamiento familiar y su relación con la crianza parental en contextos socialmente vulnerables
Authors: Morelato Gabriela , Ferrandiz Agustina , Carreras Maria Victoria , Korzeniowski Celina , Ison Mirta , Valgañon Mónica , González Arratia Norma Ivonne
Published: March 2024

Este trabajo se inserta en el estudio de las infancias y adolescencias desde la perspectiva de los recursos y la resiliencia familiar. Se propone analizar las competencias parentales en un grupo de padres, madres o cuidadores pertenecientes a contextos socialmente vulnerables; indagar aspectos de sus historias de crianza; identificar indicadores de flexibilidad y cohesión de su funcionamiento familiar y, finalmente, explorar la relación entre las variables del funcionamiento familiar y las características de sus competencias parentales con base en el paradigma de derechos. Para tal efecto se utilizó un diseño de enfoque mixto. Participaron 39 madres, padres o cuidadores a cargo de niños y niñas de edad escolar provenientes de contextos socialmente vulnerables. La información se recolectó a través de entrevistas enfocadas y la escala FACES III (Olson et al., 1989) con adaptación argentina (Leibovich et al., 2010) que evalúa adaptabilidad o flexibilidad y cohesión familiar. Los resultados señalaron bajos niveles de cohesión y flexibilidad y un funcionamiento real de tipo extremo. También se hallaron relaciones significativas entre un alto rango de adaptabilidad/flexibilidad y una función parental favorable, y la reflexión de los cuidadores acerca de su función y las crisis inesperadas. Desde ese punto de vista, cuando el tipo de función parental se enfoca en aspectos favorables y protectores también se observa un nivel de flexibilidad familiar alto, lo cual constituye un factor de resiliencia familiar. Se concluye que el funcionamiento familiar se relaciona con el desempeño actual de los cuidadores respecto a la crianza de los niños y niñas.
Development of Early Jain Manuscript Paintings: A Journey through Kalpasutra Paintings
Authors:   Indian Institute of Heritage, New Delhi, India, Lahoti Supriya
Published: March 2024

Jain manuscripts have a rich history of artistic embellishment. Interestingly, some of the earliest instances of Indian miniature paintings can be traced back to illustrated Jain manuscripts. We explore the stylistic roots of Jain manuscript paintings along with the role of patronage in the production of these manuscripts. In this scholarly exploration, we delve into the stylistic journey of these paintings, focusing specifically on the widely illustrated Kalpasutra until the 16th century. The earliest Jain manuscripts were meticulously crafted on palm leaves and encased within painted wooden covers. These early works featured sparse illustrations, often centered around decorative borders and single figures. However, with the adoption of paper, the painting style underwent significant transformation. It became more detailed and ornate, while still adhering to hieratic conventions. Noteworthy features of this style include the use of bright primary colors, precise lines, formal composition, and stylized figures with sharply defined gestures and prominent eyes. As we approach the late 15th to early 16th centuries, Jain manuscript paintings began to draw inspiration from external artistic traditions. Influences from Mamluk Egypt and Timurid Persia shaped the visual language of these illustrations. During this period, the palette shifted, with hues of blue and gold dominating the compositions, signaling a move toward a more opulent aesthetic. Production centers such as Patan, Mandu, and Jaunpur contributed distinct regional stylistic idioms to the world of Jain manuscript art. In fine, it can be said that these manuscripts serve as a testament to the intersection of spirituality, creativity, and patronage within the vibrant realm of Jain culture and art.
Semantic Model for Fragment of Hindi (Part 1)
Authors:   Research Scholar, Indian Institute of Technology (BHU) Varanasi., Tripathi Vivek , Rathod Dinesh
Published: March 2024

This paper proposes a formal model for syntactic and semantic analysis for the Hindi language using context-free grammar. In this paper, we developed a syntactic parser that generates syntactic trees for Hindi sentences based on rules of propositional logic, and gender conventions. The context-free rules we have written follow a top-down approach with a sentence that goes on self-arrangement. A set of experiments were run based on the corpus we have created, and significant results are presented in this paper. In addition to the above, the model characterizes lexical items in terms of individuals and sets for the syntactic distribution for well-formed formulas.
Palliating War Trauma: Exploring the Therapeutic Role of Nature in Silko’s Ceremony
Authors:   Assistant Professor, St. George’s College Aruvithura, Kottayam, India, Jacob Sini
Published: March 2024

Trauma has been part of human life both in its everyday and extreme forms. Man often experiences multidimensional crises leading to unanticipated trauma. Trauma includes experiences of fear, terror, and disempowerment that overpower the defence mode, threatening to paralyze the vital functions of a person or community. Marginalized people and communities who are exposed to extreme forms of atrocities are constantly exposed to traumatic experiences. The imaginative literature has a special sensitivity and affinity to trauma, offering insights into the survivors’ mentality. Moreover, it can offer reparative practices that can lead to healing. The cognitive richness and suggestive power of literature can serve as a complex medium of trauma representation. There are diverse ways of professionally dealing with trauma. Ecological modes of engagement characterized by ecological connectivity and reconstruction, lead to holistic healing for traumatized individuals. This study examines how trauma victims engaged or inter-meshed with nature are healed quickly and how the experience of nature becomes an active component of their rehabilitation. In Leslie Marmon Silko’s literary masterpiece, Ceremony, the intricate interplay between war trauma, culture, and the environment is delicately examined to unravel the profound ways in which nature serves as a healing agent in the present world. By creating a nature-based ceremony, Silko’s novel showcases how Indigenous cultures use their ecological knowledge leading to holistic healing, that transcends individual pain and trauma.
Orality and Indigenous Environmentalism in Sarah Joseph’s Gift in Green
Authors:   Research Scholar, Department of English, Gauhati University, Guwahati, Assam, India, Gogoi Darpana
Published: March 2024

In recent times, the growing recognition of the significance of indigenous storytelling extends beyond its role as a cultural repository, encompassing its potential as a wellspring of ecological and ethical insights. In this era of rapid change and globalization, understanding and appreciating the role of indigenous storytelling becomes all the more essential. It serves as a crucial reminder that, beyond the visible diversity of languages, customs, rituals, and traditions, there exists a profound shared heritage woven through narratives that have sustained these communities for ages. This study examines indices of indigenous environmental protection in Sarah Joseph’s Gift in Green (2011). The central focus of this study lies in the portrayal of storytelling nights within the narrative, arguing that storytelling not only serves as a vital instrument for cultural preservation but also manifests as an expression of environmental consciousness. Thus, this study, through a close reading of Sarah Joseph’s text unravels the transformative influence of cultural performances within indigenous communities, elucidating their role in nurturing ecological awareness and fostering sustainable practices.
Deep learning modeling framework for multi-resolution streamflow generation
Authors: Custodio Pereira do Carmo Fernanda , John Jeenu , Sushama Laxmi , Khaliq Muhammad Naveed
Published: March 2024

Generating continuous streamflow information through integrated climate-hydrology modeling at fine spatial scales of the order of a few kilometers is often challenged by computational costs associated with running high-resolution (HR) climate models. To address this challenge, the present study explores deep learning approaches to generate HR streamflow information from that at low resolution (LR), based on runoff generated by climate models. Two sets of daily streamflow simulations spanning 10 years (2011–2020), at LR (50 km) and HR (5 km), for the Ottawa River basin, Canada, are employed. The proposed deep learning model is trained using upscaled features derived from LR streamflow simulation for the 2011–2018 period as input and the corresponding HR streamflow simulation as the target; data for 2019 are used for validation. The model estimates for the year 2020, when compared with unseen HR data for the same year, suggest good performance, with differences in monthly mean values for different accumulation area categories in the −0.7–5% range and correlation coefficients for streamflow values for the same accumulation area categories in the 0.92–0.96 range. The developed framework can be ported to other watersheds for generating similar information, which is required in climate change adaptation studies.
A manifold learning perspective on surrogate modeling of nitrate concentration in the Kansas River
Authors: Tufillaro Nicholas
Published: March 2024

A non-linear surrogate model of nitrate concentration in the Kansas River (USA) is described. The model is an (almost) Piece-wise Linear response surface that provides a mean field approximation to the dynamics of the measured data for nitrate plus nitrite (target product) correlations to turbidity and chlorophyll-a concentrations (input variables). The method extends the United States Geological Survey’s linear procedures for surrogate data modeling allowing for better approximations for river systems exhibiting algal blooms due to nutrient-rich source waters. The model and visualization procedures illustrated in the Kansas River example should be generally applicable to many medium-size rivers in agricultural regions.
SWOT
Authors: Baptista Luiz Gustavo , Carneiro Cristine Elizabeth Alvarenga
Published: March 2024

Este artigo apresenta uma abordagem inovadora para aprimorar a transferência de tecnologia em Instituições de Ciência e Tecnologia (ICTs) por meio da integração dinâmica da matriz SWOT ou FOFA. Desenvolvendo um framework que transcende a análise convencional, a pesquisa desenvolveu uma abordagem estratégica mais adaptativa. A metodologia foi aplicada em um estudo de caso simulado, evidenciando a eficácia do framework na análise contínua das forças, fraquezas, oportunidades e ameaças. Os resultados apontam para uma maior agilidade e eficácia na tomada de decisões, além de revelar insights valiosos para gestores e pesquisadores envolvidos na transferência de tecnologia. A pesquisa contribui para aprimorar a compreensão da dinâmica da transferência de tecnologia, destacando a importância da abordagem dinâmica da matriz SWOT para promover uma gestão estratégica robusta.
COMPLEXIDADE NO SÉC. XXI E OS PROCESSOS ADAPTATIVOS EMERGENTES NO SERVIÇO PÚBLICO
Authors: Alves Tatiane , Bonfim de Sousa Ludimila Carolina , Rossi de Mello Brandão Marcelle
Published: March 2024

Em nome do princípio da eficiência, a Administração Pública precisa superar o trabalho burocratizado pela prestação de serviços mais ágeis e eficientes, o que exige a modernização dos seus procedimentos internos. Neste contexto, o teletrabalho se apresenta como uma alternativa para reestruturar as relações laborais na esfera pública. Esta pesquisa tem como objetivo realizar um diagnóstico situacional por meio do estudo da normatização do teletrabalho no Poder Judiciário Estadual do Centro-Oeste brasileiro utilizando a ferramenta de análise SWOT. Quanto aos procedimentos metodológicos, foi realizada pesquisa bibliográfica e documental, com abordagem qualitativa, avaliando os pontos fortes e fracos, as ameaças e oportunidades encontradas nas regulamentações das instituições em estudo, com o uso da ferramenta Matriz SWOT. Os resultados demonstraram como pontos fracos/ameaças, a necessidade de alinhamento das práticas relativas à definição dos participantes e das metas de produtividade e a capacitação dos gestores, de questões atinentes à comunicação, do isolamento do trabalhador, dos custos ligados à atividade externa, da vulnerabilidade dos dados e do desenvolvimento dos programas utilizados. E como pontos fortes/oportunidade, a qualidade de vida, a retenção de talentos, a sustentabilidade, a produtividade ampliada e a redução de despesas operacionais.
Identification of Drug Targets and Agents Associated with Ferroptosis-related
Osteoporosis through Integrated Network Pharmacology and Molecular
Docking Technology
Authors: Huo Kailun , Yang Yiqian , Yang Tieyi , Zhang Weiwei , Shao Jin
Published: March 2024

Background::

Osteoporosis is a systemic bone disease characterized by progressive reduction of
bone mineral density and degradation of trabecular bone microstructure. Iron metabolism plays an important
role in bone; its imbalance leads to abnormal lipid oxidation in cells, hence ferroptosis. In osteoporosis, however,
the exact mechanism of ferroptosis has not been fully elucidated.

Objective::

The main objective of this project was to identify potential drug target proteins and agents for the
treatment of ferroptosis-related osteoporosis.

Methods::

In the current study, we investigated the differences in gene expression of bone marrow mesenchymal
stem cells between osteoporosis patients and normal individuals using bioinformatics methods to obtain
ferroptosis-related genes. We could predict their protein structure based on the artificial intelligence database
of AlphaFold, and their target drugs and binding sites with the network pharmacology and molecular docking
technology.

Results::

We identified five genes that were highly associated with osteoporosis, such as TP53, EGFR, TGFB1,
SOX2 and MAPK14, which, we believe, can be taken as the potential markers and targets for the diagnosis
and treatment of osteoporosis. Furthermore, we observed that these five genes were highly targeted by
resveratrol to exert a therapeutic effect on ferroptosis-related osteoporosis.

Conclusion::

We examined the relationship between ferroptosis and osteoporosis based on bioinformatics and
network pharmacology, presenting a promising direction to the pursuit of the exact molecular mechanism of
osteoporosis so that a new target can be discovered for the treatment of osteoporosis.
Association of UGT1A Gene Polymorphisms with BKV Infection in Renal Transplantation Recipients
Authors: Yuan Jingwen , Fei Shuang , Gui Zeping , Wang Zijie , Chen Hao , Sun Li , Tao Jun , Han Zhijian , Ju Xiaobing , Tan Ruoyun , Gu Min , Huang Zhengkai
Published: March 2024

Background:

BK virus (BKV) infection is an opportunistic infectious complication and constitutes
a risk factor for premature graft failure in kidney transplantation. Our research aimed to identify associations
and assess the impact of single-nucleotide polymorphisms (SNPs) on metabolism-related genes in patients
who have undergone kidney transplantation with BKV infection.

Material/Methods:

The DNA samples of 200 eligible kidney transplant recipients from our center, meeting
the inclusion criteria, have been collected and extracted. Next-generation sequencing was used to genotype
SNPs on metabolism-associated genes (CYP3A4/5/7, UGT1A4/7/8/9, UGT2B7). A general linear model
(GLM) was used to identify and eliminate confounding factors that may influence the outcome events. Multiple
inheritance models and haplotype analyses were utilized to identify variation loci associated with infection
caused by BKV and ascertain haplotypes, respectively.

Results:

A total of 141 SNPs located on metabolism-related genes were identified. After Hardy-Weinberg
equilibrium (HWE) and minor allele frequency (MAF) analysis, 21 tagger SNPs were selected for further association
analysis. Based on GLM results, no confounding factor was significant in predicting the incidence of
BK polyomavirus-associated infection. Then, multiple inheritance model analyses revealed that the risk of
BKV infection was significantly associated with rs3732218 and rs4556969. Finally, we detect significant associations
between haplotype T-A-C of block 2 (rs4556969, rs3732218, rs12468274) and infection caused by
BKV (P = 0.0004).

Conclusions:

We found that genetic variants in the UGT1A gene confer BKV infection susceptibility after kidney
transplantation.
Unraveling the Role of COMT Polymorphism in Dopamine-Mediated
Vasopressor Effects: An Observational Cross-Sectional Study
Authors: Sridharan Kannan , Jassim Anfal , Mohammed Qader Ali , Pasha Sheikh Abdul Azeez
Published: March 2024

Aims::

To evaluate the association between rs4680 polymorphism in the COMT gene and the vasoconstrictive
effects of commonly used vasopressors.

Background::

Dopamine is a medication that is given intravenously to critically ill patients to help increase
blood pressure. Catechol O-Methyl Transferase (COMT) breaks down dopamine and other catecholamines.
There is a genetic variation in the COMT gene called rs4680 that can affect how well the enzyme works.
Studies have shown that people with this genetic variation may have different blood pressure levels. However,
no one has looked at how this genetic variation affects the way dopamine works to increase blood pressure.

Objectives::

To investigate the impact of the rs4680 polymorphism in the COMT gene on the pharmacodynamic
response to dopamine.

Methods::

Critically ill patients administered dopamine were included following the consent of their legally acceptable
representatives. Details on their demographic characteristics, diagnosis, drug-related details, changes
in the heart rate, blood pressure, and urinary output were obtained. The presence of rs4680 polymorphism in
the COMT gene was evaluated using a validated method.

Results::

One hundred and seventeen patients were recruited, and we observed a prevalence of rs4680 polymorphism
in 57.3% of our critically ill patients. Those with mutant genotypes were observed with an increase in
the median rate of change in mean arterial pressure (mm Hg/hour) [wild: 8.9 (-22.6 to 49.1); heterozygous mutant:
5.9 (-34.1 to 61.6); and homozygous mutant: 19.5 (-2.5 to 129.2)] and lowered urine output (ml/day)
[wild: 1080 (21.4 to 5900); heterozygous mutant: 380 (23.7 to 15800); and homozygous mutant: 316.7 (5.8 to
2308.3)].

Conclusion::

V158M (rs4680) polymorphism is widely prevalent in the population and was significantly associated
with altered effects as observed clinically. This finding suggests valuable insights into the molecular basis
of COMT function and its potential impact on neurotransmitter metabolism and related disorders. Large-scale
studies delineating the effect of these polymorphisms on various vasopressors are the need of the hour.
Individual and Dual Cytotoxicity of the Combination of Passiflora Caerulea Leaf Extract and Titanium Oxide Nanoparticles against A549, U937, and Hela Cells
Authors: Sindhura Lakku , Bobby Mohd. Nazneen , Srikanth Koigoora , Michael Helan Soundra Rani , Ashif Ikbal Abu Md , Thomas Sabu , Kargarzadeh Hanieh , Palit Partha
Published: March 2024

Background:

The study addresses the underexplored realm of cytotoxicity evaluation
involving binary mixtures of Passiflora caerulea leaf extracts and Titanium nanoparticles
(TiO2NPs). The focus lies on understanding the combined effects of these components on cancer
cells (A549, U937, and HeLa).

Methods:

In vitro cytotoxicity assessments were employed to evaluate the toxicity of P. caerulea
leaf extracts, TiO2NPs, and their combination. The study utilized MTT, NRU, and LDH assays to
measure cellular viability. Additionally, reactive oxygen species (ROS) and glutathione levels
were assessed alongside the aforementioned assays.

Results:

The toxicity percentage exhibited dose-dependent behavior for P. caerulea leaf extracts,
TiO2NPs, and their combination. Interestingly, when P. caerulea leaf extract and TiO2NPs were
combined, the reduction in cell viability was noticeably more than when the exposures were made
separately. Moreover, the production of ROS was higher in the combined toxicity scenario, and a
more pronounced decrease in glutathione levels was observed compared to individual exposures.

Conclusion:

The findings suggest that the combined effects of P. caerulea leaf extract and
TiO2NPs induce greater cytotoxicity compared to their impacts. This underscores the potential for
synergistic cytotoxicity in combined exposure scenarios, warranting further exploration of combined
effects in future studies.
Extensive Review of Literature on Explainable AI (XAI) in Healthcare Applications
Authors: Mariappan Ramasamy
Published: March 2024

:

Artificial Intelligence (AI) techniques are widely being used in the medical fields or
various applications including diagnosis of diseases, prediction and classification of diseases,
drug discovery, etc. However, these AI techniques are lacking in the transparency of the predictions
or decisions made due to their black box-type operations. The explainable AI (XAI)
addresses such issues faced by AI to make better interpretations or decisions by physicians.
This article explores XAI techniques in the field of healthcare applications, including the Internet
of Medical Things (IoMT). XAI aims to provide transparency, accountability, and traceability
in AI-based systems in healthcare applications. It can help in interpreting the predictions
or decisions made in medical diagnosis systems, medical decision support systems, smart
wearable healthcare devices, etc. Nowadays, XAI methods have been utilized in numerous
medical applications over the Internet of Things (IOT), such as medical diagnosis, prognosis,
and explanations of the AI models, and hence, XAI in the context of IoMT and healthcare has
the potential to enhance the reliability and trustworthiness of AI systems.
Confirmación de la presencia del género Macromantis Saussure, 1871 (Mantodea: Photinaidae) en México
Authors: De Luna Manuel , Hernández Baltazar Erick , Cubillos-Macías Iker
Published: March 2024

Se registra a la mantis Macromantis nicaraguae Saussure and Zehntner, 1894 (Mantodea: Photinaidae) para el estado de Chiapas, México, siendo el primer registro formal de la especie, género y familia para el país. Esto incrementa el número de familias del orden Mantodea en Norteamérica continental a 13.
Liderazgo ético en el ejercicio del mando militar de los alféreces de la Esmic
Authors: González-Ramírez Luis Fernando , Velásquez-Peláez Carlos Arturo
Published: March 2024

este capítulo analiza el proceso de formación en liderazgo ético militar de los alféreces de la Escuela Militar de Cadetes “General José María Córdova” e identifica las debilidades y fortalezas del curriculum en el plan de estudios y las estrategias metodológicas para impartir la cátedra Liderazgo Militar implementada para el desarrollo y el fortalecimiento de las competencias del ser, el saber, el hacer y el convivir de los alféreces en su fase de mando. Para ello, se recurre a un diseño metodológico de enfoque cualitativo, de tipo analítico-propositivo y a encuestas a docentes y alféreces. Entre los hallazgos se destaca que aunque se cuenta con un plan de estudios definido, la falta de continuidad de la asignatura en cuestión en la malla curricular lleva a dificultades en la fase de mando del alférez.
El Ejército Nacional de Colombia y la gestión de la logística humanitaria
Authors: Sierra-Zamora Paola Alexandra , Aristizábal-Murillo Juan Carlos
Published: March 2024

La logística humanitaria es un campo de estudio que cada día se requiere más de su compresión y entendimiento, para que las organizaciones tanto públicas como privadas que desarrollan esta actividad, fortalezcan sus procesos y procedimientos; esto debido a las diversas catástrofes naturales que se presentan como consecuencia del calentamiento global, fruto de las emisiones de gases de efecto invernadero, además el apoyo a comunidades vulnerables; en esta obra titulada “El Ejército Nacional de Colombia y la gestión de la logística humanitaria”, se pretende divulgar investigaciones académicas que se han desarrollado desde diferentes frentes y que le permiten al Ejército Nacional de Colombia y a los lectores tener una referencia para la toma de decisiones documentadas, orientadas en este campo del conocimiento. Las investigaciones que se realizaron fueron encauzadas a; la coordinación interinstitucional para la logística humanitaria en Colombia, capacidades de las Fuerzas Militares de Colombia en logística humanitaria entre (2017-2023), intersecciones de logística humanitaria, ODS y bioética, Liderazgo y logística humanitaria y logística humanitaria: capacidades y competencias del Ejército Nacional de Colombia. Para obtener los resultados se emplearon diversos métodos de investigación, lo que hace que la información obtenida sea seria, rigurosa, de alto impacto académico y científico.
Kecanduan Smartphone Ditinjau dari Sensation-Seeking pada Siswa SMA di Yogyakarta
Authors: Assari Arnia
Published: March 2024

Penelitian ini bertujuan untuk mengetahui bahwa sensation seeking memiliki pengaruh terhadap kecanduan smartphone pada siswa SMA. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kuantitatif dengan jenis penelitian survei dan dilakukan di Yogyakarta. Sampel yang digunakan berjumlah 415 siswa SMA baik negeri maupun swasta dengan teknik sampling yang digunakan adalah accidental sampling. Teknik pengumpulan data dilakukan dengan menggunakan metode kuesioner berbentuk skala. Instrumen pengambilan data menggunakan dua kuesioner, yakni kuesioner kecanduan smartphone dan sensation seeking. Uji validitas instrumen menggunakan validitas isi yang dilakukan dengan expert judgment dan uji reliabilitas menggunakan Alpha Cronbach dengan nilai koefisien 0,879 untuk instrumen kecanduan smartphone serta 0,989 untuk instrumen sensation seeking. Analisis data menggunakan teknik regresi linear sederhana. Hasil penelitian menunjukan bahwa sensation seeking mempengaruhi kecanduan smartphone siswa SMA di Yogyakarta dengan p0,05; maka variabel sensation seeking dapat memprediksi kecanduan smartphone dengan persamaan garis regresi Y = 37,690 + 0,285X.