bluuebunny/crossref_metadata_2025 huggingface dataset:
Incursion Preparedness, Citizen Science and Early Detection of Invasive Insects: The Case of Aleurocanthus spiniferus (Hemiptera, Aleyrodidae) in France
Authors: Streito Jean-Claude , Mendes Emilie , Sanquer Emmanuel , Strugarek Martin , Ouvrard David , Robin-Havret Victor , Poncet Laurent , Lannou Christian , Rossi Jean-Pierre
Published: November 2023

We describe the process by which the quarantine whitefly, Aleurocanthus spiniferus (Hemiptera, Aleyrodidae), was detected in France. The initial observation was made by a volunteer who reported a picture of an adult in the Inventaire National du Patrimoine Naturel (INPN Espèces), a citizen science resource developed by l’Office Français de la Biodiversité and the French Muséum National d’Histoire Naturelle. The specimen was suspected to be A. spiniferus from this picture by one of the expert entomologists in charge of the Hemiptera group validation. Once the species was identified, it was mounted on a slide and the information was officially passed on to the ministry in charge of agriculture via a communication channel set up in advance for this type of situation. The ministry then triggered the regulatory actions planned in the event of the suspected detection of quarantine organisms. Sampling was quickly carried out and the specimens collected on this occasion were formally identified as belonging to the species A. spiniferus. This led to the formalization of an outbreak in France. This sequence of decisions took just two months from the first observation to the implementation of a management plan. This case presents how incursion preparedness contributes to a rapid response. Furthermore, this case exemplifies how citizen science can contribute to the early detection of invasive species and highlights the importance of informing both the general public and professionals about major environmental issues.
Wavelength Characteristics and Visual Function of Photochromic Contact Lenses in Indoor and Outdoor Conditions
Authors: Suzuki Shuya , Kamiya Kazutaka , Iizuka Tatsuya , Handa Tomoya
Published: November 2023

Purpose: To examine the wavelength characteristics of photochromic contact lenses (CL) and evaluate the impact of tinting on visual function in indoor, outdoor, and glare environments. Methods: A total of 33 healthy individuals with refractive errors were recruited and fully corrected for refractive errors. Three groups were established, including non-activated photochromic CL, activated photochromic CL, and lenses without photochromic properties, which replicated the dimming characteristics of CL. Visual acuity and contrast sensitivity were measured and compared among the three groups. Results: Statistically significant differences were observed in the spatial frequency (6, 12 cpd) and contrast sensitivity outdoors, with improved values recorded in the activated photochromic-CL group. In subsequent comparisons, the activated-photochromic-CL group demonstrated significantly better contrast-sensitivity values than the non-photochromic-CL group, as well as significant improvement in contrast sensitivity compared to the non-activated-photochromic-CL group. No significant differences were observed in the indoor or outdoor visual acuity. Conclusion: Our results suggest that photochromic CL enhances visual function in outdoor environments, while maintaining visual function indoors and under glare, thereby improving the quality of vision (QOV) in severe light conditions where exposure to sunlight and ultraviolet light is anticipated.
How Imaging Techniques Improve Ventricular Arrhythmia Ablation: A Multimodality-Based Approach
Authors: Robles Antonio Gianluca , Jan Matevž , Prolič Kalinšek Tine , Antolič Bor , Rauber Martin , Klemen Luka , Šinkovec Matjaž , Romano Silvio , Sciarra Luigi , Pernat Andrej
Published: November 2023

Although implantable cardioverter defibrillators offer the best protection against sudden cardiac death, catheter ablation for ventricular arrhythmias (VAs) can modify or prevent this event from occurring. In order to achieve a successful ablation, the correct identification of the underlying arrhythmogenic substrate is mandatory to tailor the pre-procedural planning of an ablative procedure as appropriately as possible. We propose that several of the imaging modalities currently used could be merged, including echocardiography (also intracardiac), cardiac magnetic resonance, cardiac computed tomography, nuclear techniques, and electroanatomic mapping. The aim of this state-of-the-art review is to present the value of each modality, that is, its benefits and limitations, in the assessment of arrhythmogenic substrate. Moreover, VAs can be also idiopathic, and in this paper we will underline the role of these techniques in facilitating the ablative procedure. Finally, a hands-on workflow for approaching such a VA and future perspectives will be presented.
Rare within Rare: A Girl with Severe Haemophilia A and Turner Syndrome
Authors: Blag Cristina , Serban Margit , Ursu Cristina Emilia , Popa Cristina , Traila Adina , Jinca Cristian , Tomuleasa Ciprian , Bota Madalina , Ionita Ioana , Arghirescu Teodora Smaranda
Published: November 2023

A coincidental occurrence of severe haemophilia A and Turner syndrome in a female person is extremely rare (less than 10 cases published). In such challenging cases, a multidisciplinary approach based on medicine of precision with full access to genetic and bio-molecular exploration is indispensable. The article presents an eight-year-old girl, with a family history of haemophilia, without significant disease signs (only post-dental extraction bleeding and a shorter stature). Discordantly, however, the investigations revealed a challenging condition: a genotype of 46,X,i(Xq), with an Isochromosome Xq responsible for the Turner syndrome and simultaneously, for the detrimental transformation, interfering with X chromosome inactivation, of an obligate hemophilia carrier into a severe hemophilia case—two distinct and provocative diseases.
Temozolomide, Procarbazine and Nitrosoureas in the Therapy of Malignant Gliomas: Update of Mechanisms, Drug Resistance and Therapeutic Implications
Authors: Kaina Bernd
Published: November 2023

The genotoxic methylating agents temozolomide (TMZ) and procarbazine and the chloroethylating nitrosourea lomustine (CCNU) are part of the standard repertoire in the therapy of malignant gliomas (CNS WHO grade 3 and 4). This review describes the mechanisms of their cytotoxicity and cytostatic activity through apoptosis, necroptosis, drug-induced senescence, and autophagy, interaction of critical damage with radiation-induced lesions, mechanisms of glioblastoma resistance to alkylating agents, including the alkyltransferase MGMT, mismatch repair, DNA double-strand break repair and DNA damage responses, as well as IDH-1 and PARP-1. Cyclin-dependent kinase inhibitors such as regorafenib, synthetic lethality using PARP inhibitors, and alternative therapies including tumor-treating fields (TTF) and CUSP9v3 are discussed in the context of alkylating drug therapy and overcoming glioblastoma chemoresistance. Recent studies have revealed that senescence is the main trait induced by TMZ in glioblastoma cells, exhibiting hereupon the senescence-associated secretory phenotype (SASP). Strategies to eradicate therapy-induced senescence by means of senolytics as well as attenuating SASP by senomorphics are receiving increasing attention, with therapeutic implications to be discussed.
Smart Composite Booms for Solar Sails
Authors: Quadrini Fabrizio , Iorio Leandro , Santo Loredana , Circi Christian , Cavallini Enrico , Pellegrini Rocco Carmine
Published: November 2023

Composite booms for solar sails have been prototyped by using innovative smart materials. Shape memory polymer composites (SMPCs) have been manufactured by interposing SMP layers between carbon-fiber-reinforced (CFR) plies. A polyimide membrane has been embedded into the CFR-SMPC frame of the sail during lamination. The sail’s size has been limited to 250 × 250 mm2 to allow its testing on Earth. The feasibility of large sail deployments has been shown by prototyping small CFR-SMPC elements to insert only in the folding zones. Numerical simulation by finite element modeling allowed for predicting the presence of wrinkles close to the frame’s vertexes in the cases of large sails under solar radiation pressures. Nevertheless, the frame’s configuration, with SMPC booms at all the edges of the sail membrane, seems to be suitable for drag sails instead of propulsion. On-Earth recovery tests have been performed on 180° folded sails by using flexible heaters. After an initial induction time, the maximum rate was reached with a following drop. In the case of two heaters per folding zone, the angular recovery rate reached the maximum value of about 30 deg/s at the power of 34 W, and full recovery was made in 20 s.
The Relationship between Executive Functions and Metacognition in College Students
Authors: Wu Mengjiao , Was Christopher A.
Published: November 2023

This study investigated the relationship between executive functions and metacognition. Both constructs have been well-studied, but little research has focused on their connections. The goal of the current investigation was to increase the understanding of the relationship between metacognition and executive functions by assessing the relationships between metacognitive monitoring accuracy and the three component executive functions (updating, inhibition, and shifting) among college students. Metacognitive monitoring accuracy was measured using a knowledge monitoring accuracy (KMA) test. The three components of executive functions, updating, inhibition, and shifting were measured, respectively, using the ABCD updating task, the Stroop color–word interference test, and the letter–number task. The Tower of Hanoi task was used to measure the complex executive functions (inhibition and updating). Correlation and regression analyses were performed to examine the relationships. The results indicate that updating is the only component executive function that significantly correlated with metacognitive monitoring, suggesting that metacognition—specifically, metacognitive monitoring—is associated with at least one component of executive functioning.
An Underwater Distributed SLAM Approach Based on Improved GMRBnB Framework
Authors: Zhang Feihu , Xu Diandian , Cheng Chensheng
Published: November 2023

Multi-vehicle collaborative mapping proves more efficient in constructing maps in unfamiliar underwater environments in comparison to single-vehicle methods. One of the pivotal hurdles of Simultaneous Localization and Mapping (SLAM) with multiple underwater vehicles is map registration. Due to the inadequate characteristics of the underwater grid maps, matching map features poses a challenge, and outliers between maps add to the complexity. We propose an algorithm to solve this problem. This approach employs the Gaussian Mixture Robust Branch and Bound (GMRBnB) algorithm with an interior point filtering technique. Feature point extraction, registration using the GMRBnB algorithm, inlier extraction based on density, and registration of the inlier are performed to obtain a more precise transformation matrix. The results of the simulation and experiments demonstrate that this technique heightens outlier tolerance and reinforces map registration accuracy. The proposed approach surpasses Iterative Closest Point (ICP) and Normal Distributions Transform (NDT) methods with respect to map registration quality.
Study on Vibration Attenuation Performance of Pump-Jet Propulsor Duct with an Axial Slot Structure
Authors: Ke Lin , Ye Jinming , Zou Xiaoyu
Published: November 2023

To reduce the structural vibration of the duct structure in pump-jet propulsors (PJPs) and lower the induced vibration noise, this study learned from the “processor box” in an aero-engine and set a certain number of axial slots in the PJP. First, using finite element analysis, both dry and wet modes of the PJP ducts with and without an axial slot structure were simulated for analysis. Next, with the two-way fluid–solid coupling calculation method, the vibration performances of the PJP ducts with and without axial slots were contrasted and studied. The differences in calculation results under different duct structures were compared from three aspects—the vibration displacement, velocity, and acceleration of the duct and mesh nodes. According to the present results, after the addition of axial slots, the vibration displacement, the vibration velocity, and the vibration acceleration can be significantly reduced, especially in the back segment of the duct. Meanwhile, it can be concluded that it is quite important to select vibration acceleration for structural analysis in evaluating the PJP vibration. This study can provide a reference for further designs of low-noise PJPs.
Implementation of an Efficient Image Transmission Algorithm for Unmanned Surface Vehicles Based on Semantic Communication
Authors: Chen Yuanming , Hong Xiaobin , Cui Bin , Peng Rongfa
Published: November 2023

With the increasingly maturing technology of unmanned surface vehicles (USVs), their applications are becoming more and more widespread. In order to meet operational requirements in complex scenarios, the real-time interaction and linkage of a large amount of information is required between USVs, between USVs and mother ships, and between USVs and shore-based monitoring systems. Visual images are the main perceptual information gathered from USVs, and their efficient transmission and recognition directly affect the real-time performance of information exchange. However, poor maritime communication signals, strong channel interference, and low bandwidth pose great challenges to efficient image transmission. Traditional image transmission methods have difficulty meeting the real-time and image quality requirements of visual image transmissions from USVs. Therefore, this paper proposes an efficient method for visual image transmission from USVs based on semantic communication. A self-encoder network for semantic encoding which compresses the image into low-dimensional latent semantics through the encoding end, thereby preserving semantic information while greatly reducing the amount of data transmitted, is designed. On the other hand, a generative adversarial network is designed for semantic decoding. The decoding end decodes and reconstructs high-quality images from the semantic information transmitted through the channel, thereby improving the efficiency of image transmission. The experimental results show that the performance of the algorithm is significantly superior to traditional image transmission methods, achieving the best image quality while transmitting the minimum amount of data. Compared with the typical BPG algorithm, when the compression ratio of the proposed algorithm is 51.6% of that of the BPG algorithm, the PSNR and SSIM values are 7.6% and 5.7% higher than the BPG algorithm, respectively. And the average total time of the proposed algorithm is only 59.4% of that of the BPG algorithm.
Oxidation of Alloy X-750 with Low Iron Content in Simulated BWR Environment
Authors: Tuzi Silvia , Stiller Krystyna , Thuvander Mattias
Published: November 2023

This paper presents an investigation of the oxidation of Alloy X-750 containing 5 wt% iron in a simulated boiling water reactor (BWR) environment. The specimens were exposed by a water jet (10 m/s) at 286 °C for durations ranging from 2 to 840 h, and the development of the oxide microstructure was mainly studied using electron microscopy. The results showed that the oxide scale consists of blocky crystals of trevorite on top of a porous inner layer rich in Ni and Cr. After the longest exposure time, the trevorite crystals completely covered the specimen surface. The study further revealed that the rate at which the oxide grew and the metal dissolved both decreased with time, and the metal thinning process appeared to be sub-parabolic. Given the significant variation in iron content in the X-750 specification, the influence of this element on the material’s corrosion performance in BWR was examined by comparing the results from this investigation with those from previous work on material containing 8 wt% Fe. The study demonstrates that the oxide growth, metal dissolution and metal thinning were slower in the material with a higher iron content, indicating the importance of this element in limiting the degradation of Alloy X-750 in BWR environments.
Inferential Interrogatives with qué in Spanish
Authors: Jiménez-Fernández Ángel L. , Tubino-Blanco Mercedes
Published: November 2023

In this paper, we discuss the evidential properties of inferential interrogative sentences with qué in Spanish. This interrogative type exhibits the shape of a wh-question but the interpretation of a polar question. These sentences have the additional particularity that they are interrogatives with evidential material, which are attested but not frequent crosslinguistically, if compared with declarative evidentials. An interesting consequence of their double interrogative and evidential nature is the fact that both discourse participants have a prominent role in the interpretation of these sentences, as the Speaker makes the inference but the Addressee is requested for confirmation. To account for the construction, we assume a multiple-layered system that includes both Speech Act projection and Finiteness projection. In these two areas we simultaneously find evidential material housing the Speaker’s inference, and a raised Addressee in its prominent interrogative position as the participant with the knowledge to provide the requested confirmation of the interrogative’s truth value.
Domestic Animal Models of Central Nervous System Tumors: Focus on Meningiomas
Authors: Tomanelli Michele , Florio Tullio , Vargas Gabriela , Pagano Aldo , Modesto Paola
Published: November 2023

Intracranial primary tumors (IPTs) are aggressive forms of malignancies that cause high mortality in both humans and domestic animals. Meningiomas are frequent adult IPTs in humans, dogs, and cats, and both benign and malignant forms cause a decrease in life quality and survival. Surgery is the primary therapeutic approach to treat meningiomas, but, in many cases, it is not resolutive. The chemotherapy and targeted therapy used to treat meningiomas also display low efficacy and many side effects. Therefore, it is essential to find novel pharmacological approaches to increase the spectrum of therapeutic options for meningiomas. This review analyzes the similarities between human and domestic animal (dogs and cats) meningiomas by evaluating the molecular and histological characteristics, diagnosis criteria, and treatment options and highlighting possible research areas to identify novel targets and pharmacological approaches, which are useful for the diagnosis and therapy of this neoplasia to be used in human and veterinary medicine.
A Comparative Analysis of the Protein Cargo of Extracellular Vesicles from Helminth Parasites
Authors: Ancarola María Eugenia , Maldonado Lucas L. , García Lucía C. A. , Franchini Gisela R. , Mourglia-Ettlin Gustavo , Kamenetzky Laura , Cucher Marcela A.
Published: November 2023

Helminth parasites cause debilitating—sometimes fatal—diseases in humans and animals. Despite their impact on global health, mechanisms underlying host–parasite interactions are still poorly understood. One such mechanism involves the exchange of extracellular vesicles (EVs), which are membrane-enclosed subcellular nanoparticles. To date, EV secretion has been studied in helminth parasites, including EV protein content. However, information is highly heterogeneous, since it was generated in multiple species, using varied protocols for EV isolation and data analysis. Here, we compared the protein cargo of helminth EVs to identify common markers for each taxon. For this, we integrated published proteomic data and performed a comparative analysis through an orthology approach. Overall, only three proteins were common in the EVs of the seven analyzed species. Additionally, varied repertoires of proteins with moonlighting activity, vaccine antigens, canonical and non-canonical proteins related to EV biogenesis, taxon-specific proteins of unknown function and RNA-binding proteins were observed in platyhelminth and nematode EVs. Despite the lack of consensus on EV isolation protocols and protein annotation, several proteins were shown to be consistently detected in EV preparations from organisms at different taxa levels, providing a starting point for a selective biochemical characterization.
Heteroctenus junceus Scorpion Venom Modulates the Concentration of Pro-Inflammatory Cytokines in F3II Tumor Cells
Authors: Yglesias-Rivera Arianna , Sánchez-Rodríguez Hermis , Soto-Febles Carmen , Monzote Lianet
Published: November 2023

The ability of Heteroctenus junceus scorpion venom to modulate the concentration of cytokines related to its antitumoral effect is unknown. F3II cells were treated with ¼ IC50, ½ IC50 and the IC50 of H. junceus scorpion venom. Tumor growth kinetics in F3II-bearing mice were evaluated after 24 days of oral administration of venom doses. The effect of tumor lysates on F3II cell viability was evaluated by MTT assay, while cytokines present in each sample were determined by ELISA. In supernatant, H. junceus scorpion venom decreased the concentration of IL-6 (p < 0.001), IFN-γ (p < 0.001), IL-1β (p < 0.01); meanwhile IL-12 (p < 0.001) and TNF-α (p < 0.001) levels increased significantly, according to the concentration and the time of incubation. Heteroctenus junceus scorpion venom effectively inhibits in vivo tumor progression. In the sera, a significant decrease was observed in TNF-α levels (p < 0.05). In tumor lysates, IL-6 decreased significantly in the groups treated with 12.5 mg/kg (p < 0.001) and 25 mg/kg (p < 0.05). Heteroctenus junceus scorpion venom is capable of modulating other proinflammatory and protumoral cytokines involved in the inflammation associated with cancer.
Bipartite Consensus Problems for Directed Signed Networks with External Disturbances
Authors: Huo Baoyu , Ma Jian , Du Mingjun
Published: November 2023

The intention of this paper is to explore the distributed control issues for directed signed networks in the face of external disturbances under strongly connected topologies. A new class of nonsingular transformations is provided by introducing an output variable, with which the consensus can be equivalently transformed into the output stability regardless of whether the associated signed digraphs are structurally balanced or not. By taking advantage of the standard robust H∞ control theory, the bipartite consensus and state stability results can be built for signed networks under structurally balanced and unbalanced conditions, respectively, in which the desired disturbance rejection performances can also be satisfied. Furthermore, the mathematical expression can be given for the terminal states of signed networks under the influence of external disturbances. In addition, two simulations are presented to verify the correctness of our developed results.
Multiple Hopf Bifurcations of Four Coupled van der Pol Oscillators with Delay
Authors: Liu Liqin , Zhang Chunrui
Published: November 2023

In this paper, a system of four coupled van der Pol oscillators with delay is studied. Firstly, the conditions for the existence of multiple periodic solutions of the system are given. Secondly, the multiple periodic solutions of spatiotemporal patterns of the system are obtained by using symmetric Hopf bifurcation theory. The normal form of the system on the central manifold and the bifurcation direction of the bifurcating periodic solutions are derived. Finally, numerical simulations are attached to demonstrate our theoretical results.
Proximity Point Results for Generalized p-Cyclic Reich Contractions: An Application to Solving Integral Equations
Authors: Alamri Hind , Hussain Nawab , Altun Ishak
Published: November 2023

This article studies new classes of contractions called the p-cyclic Reich contraction and p-cyclic Reich contraction pair and develops certain best proximity point results for such contractions in the setting of partial metric spaces. Furthermore, the best proximity point results for p-proximal cyclic Reich contractions of the first and second types are also discussed.
Dynamic Analysis of Impulsive Differential Chaotic System and Its Application in Image Encryption
Authors: Guo Junrong , Liu Xiaolin , Yan Ping
Published: November 2023

In this paper, we study the dynamic behavior of an impulse differential chaotic system which can be applied to image encryption. Combined with the chaotic characteristics of the high dimensional impulsive differential equations, the plaintext image can be encrypted by using the traditional Henon map and diffusion sequences encryption algorithm. The initial values and control parameters serve as keys for encryption algorithms, and the algorithm has a larger key space. The key is resistant to minor interference and the accuracy can reach 10−12. The simulation results show that the impulsive differential chaotic system has a good application prospect in image encryption.
Bayes Inference of Structural Safety under Extreme Wind Loads Based upon a Peak-Over-Threshold Process of Exceedances
Authors: Chiodo Elio , De Angelis Fabio , Diban Bassel , Mazzanti Giovanni
Published: November 2023

In the present paper, the process of estimating the important statistical properties of extreme wind loads on structures is investigated by considering the effect of large variability. In fact, for the safety design and operating conditions of structures such as the ones characterizing tall buildings, wind towers, and offshore structures, it is of interest to obtain the best possible estimates of extreme wind loads on structures, the recurrence frequency, the return periods, and other stochastic properties, given the available statistical data. In this paper, a Bayes estimation of extreme load values is investigated in the framework of structural safety analysis. The evaluation of extreme values of the wind loads on the structures is performed via a combined employment of a Poisson process model for the peak-over-threshold characterization and an adequate characterization of the parent distribution which generates the base wind load values. In particular, the present investigation is based upon a key parameter for assessing the safety of structures, i.e., a proper safety index referred to a given extreme value of wind speed. The attention is focused upon the estimation process, for which the presented procedure proposes an adequate Bayesian approach based upon prior assumptions regarding (1) the Weibull probability that wind speed is higher than a prefixed threshold value, and (2) the frequency of the Poisson process of gusts. In the last part of the investigation, a large set of numerical simulations is analyzed to evaluate the feasibility and efficiency of the above estimation method and with the objective to analyze and compare the presented approach with the classical Maximum Likelihood method. Moreover, the robustness of the proposed Bayes estimation is also investigated with successful results, both with respect to the assumed parameter prior distributions and with respect to the Weibull distribution of the wind speed values.
Association of Gestational Hypertension with Sociodemographic and Anthropometric Factors, Perinatal Outcomes, Breastfeeding Practices, and Mediterranean Diet Adherence: A Cross-Sectional Study
Authors: Pavlidou Eleni , Papadopoulou Sousana K. , Alexatou Olga , Tsourouflis Gerasimos , Antasouras Georgios , Louka Aikaterini , Chatziprodromidou Ioanna P. , Mentzelou Maria , Sampani Anastasia , Chrysafi Maria , Apostolou Thomas , Dakanalis Antonios , Papadopoulou Vasiliki G. , Giaginis Constantinos
Published: November 2023

Background and Objectives: Gestational hypertension has been associated with several pregnancy short-term and long-term complications, affecting both the mother and her infant’s health. The present study aims to assess the potential association of gestational hypertension with sociodemographic and anthropometry factors, perinatal outcomes, breastfeeding habits, and Mediterranean diet (MD) compliance. Materials and Methods: This is a cross-sectional study conducted on 5271 mothers that was carried out after delivery. The anthropometry characteristics and perinatal outcomes were retrieved from the mothers’ medical records. Sociodemographic characteristics, MD adherence, and breastfeeding habits were assessed via one-to-one interviews of the assigned women with qualified staff. Results: Maternal older age, being employed, family history of gestational hypertension, overweight/obesity before gestation, and abnormal gestational weight gain (GWG) independently increased the risk of developing gestational hypertension. Moreover, gestational hypertension was independently related with a greater incidence of abnormal childbirth body weight and preterm birth, not exclusively breastfeeding, and lower levels of MD adherence. Conclusions: This study highlights the importance of informing future mothers about the risk factors of gestational hypertension, underlining also that a healthy lifestyle, which simultaneously includes a healthy nutritional pattern such as MD, may decrease the risk of developing gestational hypertension and the subsequent pregnancy complications.
Risk Factors and Clinical Outcomes of Osteotomy Plane Violation by D-Hole Screws in Medial Open Wedge High Tibial Osteotomy: A Simulation and Comparative Study
Authors: Kim Sung Eun , Lee Myung Ho , Cho Chan Hee , Lee Jung-In , Han Hyuk-Soo , Lee Myung Chul , Ro Du Hyun
Published: November 2023

Background and Objectives: Stable fixation is essential for successful healing after medial open wedge high tibial osteotomy (MOWHTO) to minimize the risk of non-union and correction loss. In Asians, potential complications such as D-hole screw osteotomy plane violation (D-hole violation) and inadequate plate fitting arise due to improper plate size. This study aimed to evaluate the risk factors for D-hole violation and compare the conventional anatomic (CA) plate with an individualized anatomic (IA) plate in MOWHTO procedures. Materials and Methods: A simulation study on D-hole violation using the CA plate was conducted, involving preoperative radiographs and CT scans of 64 lower extremities from 47 MOWHTO patients. Additionally, a randomized controlled study compared CA and IA plates in MOWHTO procedures with 34 patients (17 in the CA plate group; 18 in the IA plate group). Patient demographics, patient-reported outcome measures (PROMs), and radiological measures were analyzed. Results: In the simulation study, the rates of D-hole violation ranged from 20.3% to 59.4%, with an increase observed as the plate was distalized from 5 mm to 10 mm away from the joint line. Short stature was identified as an independent risk factor for D-hole violation (p < 0.001), with a cutoff value of 155.3 cm. In the randomized controlled study, no significant difference in PROMs and D-hole violation was observed between the CA plate and IA plate groups. However, the IA plate group showed better plate fitting compared to the CA plate group (p = 0.041). Conclusions: This study identified a high risk of D-hole screw osteotomy plane violations in MOWHTO procedures, particularly when the plate is positioned more distally and in individuals with a stature below 155.3 cm. It also revealed that individualized plates provide better tibial fitting compared to conventional anatomic plates, particularly in Asian populations where tibial morphology tends to be shorter than in Western populations. Therefore, evaluating patient stature and selecting tailored plates are essential to optimize plate positioning and minimize plate-related complications in MOWHTO procedures.
Surface-Modified Pore-Filled Anion-Exchange Membranes for Efficient Energy Harvesting via Reverse Electrodialysis
Authors: Lee Ji-Hyeon , Kim Do-Hyeong , Kang Moon-Sung
Published: November 2023

In this study, novel pore-filled anion-exchange membranes (PFAEMs) modified with polypyrrole (PPy) and reduced graphene oxide (rGO) were developed to improve the energy harvesting performance of reverse electrodialysis (RED). The surface-modified PFAEMs were fabricated by varying the contents of PPy and rGO through simple spin coating and chemical/thermal treatments. It was confirmed that the PPy and PPy/rGO layers introduced on the membrane surface did not significantly increase the electrical resistance of the membrane and could effectively control surface characteristics, such as structural tightness, hydrophilicity, and electrostatic repulsion. The PPy/rGO-modified PFAEM showed excellent monovalent ion selectivity, more than four times higher than that of the commercial membrane (AMX, Astom Corp., Tokyo, Japan). This means that the PPy/rGO layer can effectively reduce the permeation of multivalent ions with a high charge intensity and a relatively large hydration radius compared to monovalent ions. The results of evaluating the performance of the surface-modified PFAEMs by applying them to a RED cell revealed that the decrease in potential difference occurring in the membrane was reduced by effectively suppressing the uphill transport of multivalent ions. Consequently, the PPy/rGO-modified membrane exhibited a 5.43% higher power density than the AMX membrane.
Intersection of Gender and Disability on Returns to Education: A Case from Metro Manila, Philippines
Authors: Lamichhane Kamal , Watanabe Takayuki
Published: November 2023

Utilizing a dataset from Metro Manila in the Philippines, we estimate the impact of gender on the return of education for individuals with disabilities, specifically focusing on visual, hearing, and walking difficulties. Controlling sample selection to address endogenous labor participation and accounting for the endogeneity of schooling decisions, our estimations reveal a significant rate of return to education, ranging from 25.7% to 38.1%. Importantly, examining the potential for nonlinear-schooling return, we observe a more pronounced effect of disability for females compared to their male counterparts, suggesting the presence of dual discrimination and signaling effects for females. Our research emphasizes the urgency for the Philippine government to not only improve educational opportunities but also to enhance employment prospects, particularly for females with disabilities. Some of the policy recommendations would include the implementation of equal-opportunity measures, including antidiscrimination policies; an expanded quota system to boost employment opportunities; efforts to address accessibility issues; and subsidies for private-sector employment are also necessary for the economic empowerment of females with disabilities.
BBD Driven Fabrication of Hydroxyapatite Engineered Risedronate Loaded Thiolated Chitosan Nanoparticles and Their In Silico, In Vitro, and Ex Vivo Studies
Authors: Saifi Zoya , Ralli Tanya , Rizwanullah Md. , Alam Meraj , Vohora Divya , Mir Showkat R. , Amin Saima , Ameen Sadia
Published: November 2023

Risedronate sodium (RIS) exhibits limited bioavailability and undesirable gastrointestinal effects when administered orally, necessitating the development of an alternative formulation. In this study, mPEG-coated nanoparticles loaded with RIS-HA-TCS were created for osteoporosis treatment. Thiolated chitosan (TCS) was synthesized using chitosan and characterized using DSC and FTIR, with thiol immobilization assessed using Ellman’s reagent. RIS-HA nanoparticles were fabricated and conjugated with synthesized TCS. Fifteen batches of RIS-HA-TCS nanoparticles were designed using the Box–Behnken design process. The nanoparticles were formulated through the ionic gelation procedure, employing tripolyphosphate (TPP) as a crosslinking agent. In silico activity comparison of RIS and RIS-HA-TCS for farnesyl pyrophosphate synthetase enzyme demonstrated a higher binding affinity for RIS. The RIS-HA-TCS nanoparticles exhibited 85.4 ± 2.21% drug entrapment efficiency, a particle size of 252.1 ± 2.44 nm, and a polydispersity index of 0.2 ± 0.01. Further conjugation with mPEG resulted in a particle size of 264.9 ± 1.91 nm, a PDI of 0.120 ± 0.01, and an encapsulation efficiency of 91.1 ± 1.17%. TEM confirmed the spherical particle size of RIS-HA-TCS and RIS-HA-TCS-mPEG. In vitro release studies demonstrated significantly higher release for RIS-HS-TCS-mPEG (95.13 ± 4.64%) compared to RIS-HA-TCS (91.74 ± 5.13%), RIS suspension (56.12 ± 5.19%), and a marketed formulation (74.69 ± 3.98%). Ex vivo gut permeation studies revealed an apparent permeability of 0.5858 × 10−1 cm/min for RIS-HA-TCS-mPEG, surpassing RIS-HA-TCS (0.4011 × 10−4 cm/min), RIS suspension (0.2005 × 10−4 cm/min), and a marketed preparation (0.3401 × 10−4 cm/min).
Flash-Based Computing-in-Memory Architecture to Implement High-Precision Sparse Coding
Authors: Qi Yueran , Feng Yang , Wang Hai , Wang Chengcheng , Bai Maoying , Liu Jing , Zhan Xuepeng , Wu Jixuan , Wang Qianwen , Chen Jiezhi
Published: November 2023

To address the concerns with power consumption and processing efficiency in big-size data processing, sparse coding in computing-in-memory (CIM) architectures is gaining much more attention. Here, a novel Flash-based CIM architecture is proposed to implement large-scale sparse coding, wherein various matrix weight training algorithms are verified. Then, with further optimizations of mapping methods and initialization conditions, the variation-sensitive training (VST) algorithm is designed to enhance the processing efficiency and accuracy of the applications of image reconstructions. Based on the comprehensive characterizations observed when considering the impacts of array variations, the experiment demonstrated that the trained dictionary could successfully reconstruct the images in a 55 nm flash memory array based on the proposed architecture, irrespective of current variations. The results indicate the feasibility of using Flash-based CIM architectures to implement high-precision sparse coding in a wide range of applications.
Metagenomic Sequencing of Lloviu Virus from Dead Schreiber’s Bats in Bosnia and Herzegovina
Authors: Goletic Sejla , Goletic Teufik , Omeragic Jasmin , Supic Jovana , Kapo Naida , Nicevic Melisa , Skapur Vedad , Rukavina Dunja , Maksimovic Zinka , Softic Adis , Alic Amer
Published: November 2023

Bats are a natural host for a number of viruses, many of which are zoonotic and thus present a threat to human health. RNA viruses of the family Filoviridae, many of which cause disease in humans, have been associated with specific bat hosts. Lloviu virus is a Filovirus which has been connected to mass mortality events in Miniopterus schreibersii colonies in Spain and Hungary, and some studies have indicated its immense zoonotic potential. A die-off has been recorded among Miniopterus schreibersii in eastern Bosnia and Herzegovina for the first time, prompting the investigation to determine the causative agent. Bat carcasses were collected and subjected to pathological examination, after which the lung samples with notable histopathological changes, lung samples with no changes and guano were analyzed using metagenomic sequencing and RT-PCR. A partial Lloviu virus genome was sequenced from lung samples with histopathological changes and found to be closely related to Hungarian and Italian virus sequences. Further accumulation of mutations on the GP gene, coding the glycoprotein responsible for cell tropism and host preference, enhances the need for further characterization and monitoring of this virus to prevent spillover events and protect human health.
Roles of Hcp2, a Hallmark of T6SS2 in Motility, Adhesive Capacity, and Pathogenicity of Vibrio alginolyticus
Authors: Wu Shuilong , Tang Jufen , Wang Bei , Cai Jia , Jian Jichang
Published: November 2023

The type VI secretion system (T6SS) is a large secretory device, widely found in Gram-negative bacteria, which plays important roles in virulence, bacterial competition, and environmental adaptation. Vibrio alginolyticus (V. alginolyticus) is an opportunistic pathogen that causes vibriosis in aquaculture animals. V. alginolyticus possesses two type VI secretion systems (named the T6SS1 and T6SS2), but their functions remain largely unclear. In this paper, the roles of the core component of the T6SS2 cluster of V. alginolyticus HY9901, hemolysin-coregulated protein2 coding gene hcp2, are reported. Deletion of hcp2 clearly impaired the swarming motility, adhesive capacity, and pathogenicity of V. alginolyticus against zebrafish. Furthermore, transmission electron microscopy (TEM) found that the abnormal morphology of flagellum filament in the hcp2 mutant strain could be partially restored by hcp2 complementarity. By proteomic and RT-qPCR analysis, we confirmed that the expression levels of flagellar flagellin and assembly-associated proteins were remarkably decreased in an hcp2 mutant strain, compared with the wild-type strain, and could be partially restored with a supply of hcp2. Accordingly, hcp2 had a positive influence on the transcription of flagellar regulons rpoN, rpoS, and fliA; this was verified by RT-qPCR. Taken together, these results suggested that hcp2 was involved in mediating the motility, adhesion, and pathogenicity of Vibrio alginolyticus through positively impacting its flagellar system.
Application of Encapsulation Strategies for Probiotics: From Individual Loading to Co-Encapsulation
Authors: Agriopoulou Sofia , Tarapoulouzi Maria , Varzakas Theodoros , Jafari Seid Mahdi
Published: November 2023

Consumers are increasingly showing a preference for foods whose nutritional and therapeutic value has been enhanced. Probiotics are live microorganisms, and their existence is associated with a number of positive effects in humans, as there are many and well-documented studies related to gut microbiota balance, the regulation of the immune system, and the maintenance of the intestinal mucosal barrier. Hence, probiotics are widely preferred by consumers, causing an increase in the corresponding food sector. As a consequence of this preference, food industries and those involved in food production are strongly interested in the occurrence of probiotics in food, as they have proven beneficial effects on human health when they exist in appropriate quantities. Encapsulation technology is a promising technique that aims to preserve probiotics by integrating them with other materials in order to ensure and improve their effectiveness. Encapsulated probiotics also show increased stability and survival in various stages related to their processing, storage, and gastrointestinal transit. This review focuses on the applications of encapsulation technology in probiotics in sustainable food production, including controlled release mechanisms and encapsulation techniques.
Extensive Validation of a New Rock Breakage Test
Authors: Bueno Marcos de Paiva , Almeida Thiago , Powell Malcolm
Published: November 2023

Comminution is the most power-demanding stage, and the lack of geometallurgical testing, often for financial reasons, may result in an inefficient operation. The Geopyörä rock breakage test was developed with the objective of making mineral variability data more accessible by providing both standard comminution parameters and rock mechanical properties at low cost and with a modest sample size, allowing a larger number of samples to be tested to reduce uncertainties and assure productivity. The objective of this work is to present the results of an extensive validation of this new rock breakage method against two of the main tests currently in use, namely the SMC and Bond ball mill work index tests. More than 100 samples have been tested and the results compared, showing that the new method can accurately estimate the parameters of the traditional tests. This confirms that the new test is a reliable tool for performing comminution and geometallurgical tests.
The Effects of Transcranial Direct Current Stimulation in Patients with Mild Cognitive Impairment
Authors: Palimariciuc Matei , Oprea Dan Cătălin , Cristofor Ana Caterina , Florea Tudor , Dobrin Romeo Petru , Dobrin Irina , Gireadă Bogdan , Gavril Radu , Mawas Iasmin , Bejenariu Andreea Cristina , Knieling Anton , Ciobica Alin , Chiriță Roxana
Published: November 2023

Transcranial direct current stimulation (tDCS) came into consideration in recent years as a promising, non-invasive form of neuromodulation for individuals suffering from mild cognitive impairment (MCI). MCI represents a transitional stage between normal cognitive aging and more severe cognitive decline, which appears in neurodegenerative diseases, such as Alzheimer’s disease. Numerous studies have shown that tDCS can have several useful effects in patients with MCI. It is believed to enhance cognitive functions, including memory and attention, potentially slowing down the progression of neurodegeneration and cognitive decline. tDCS is believed to work by modulating neuronal activity and promoting synaptic plasticity in the brain regions associated with cognition. Moreover, tDCS is generally considered safe and well-tolerated, making it an attractive option for long-term therapeutic use in MCI. However, further research is needed to determine the optimal stimulation parameters and long-term effects of tDCS in this population, as well as its potential to serve as a complementary therapy alongside other interventions for MCI. In this review, we included 16 randomized clinical trials containing patients with MCI who were treated with tDCS. We aim to provide important evidence for the cognitive enhancement using tDCS in patients with MCI, summarizing the effects and conclusions found in several clinical trials, and discuss its main mechanisms.
Dietary Bioactive Compounds: Implications for Oxidative Stress and Inflammation
Authors: Cuffaro Doretta , Digiacomo Maria , Macchia Marco
Published: November 2023

Nowadays, it has been amply demonstrated how an appropriate diet and lifestyle are essential for preserving wellbeing and preventing illnesses [...]
Charting the Chronology of Research on Added Sugars: A Scoping Review and Evidence Map
Authors: Fleming Stephen A. , Peregoy Jennifer A. , Paul Tristen L. , Scott Maria O. , Gaine P. Courtney
Published: November 2023

The objective of this study was to conduct a scoping review and produce a publicly available database characterizing the design and reporting elements of the literature on dietary added sugars and select health outcomes. Relevant studies published from 1990 to 2021 were identified to create a database containing information on study and population characteristics, reported added sugars source and concentrations, dietary energy balance, total energy intake, and outcome measures related to body composition, obesity, cardiovascular disease, and diabetes mellitus. There were 245 publications identified, 22% of which describe interventions, and 78% describe observational studies. Publications pertaining to added sugars have risen dramatically since 2010, led by studies primarily assessing body composition (36%) or cardiovascular health (32%), including adults (65%), measuring liquid-only sources of added sugars (56%). Over 65% of studies reported total energy intake, 61% controlled for total energy intake in the design and analysis, and fewer than 5% of studies reported the energy balance of subjects. There has been a significant increase in research on added sugars since 2010, with substantial heterogeneity across all facets of methodology—study designs, exposures and outcomes of interest, terminology, and reporting of dietary intake data—thus limiting the ability to synthesize evidence in this scope of the literature. This evidence map highlights gaps and important areas for improvement to strengthen the state of research and better inform future policies and dietary recommendations on added sugars.