bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of exogenous surfactant in pulmonological practice
Authors: Ignatova G. L. , Antonov V. N. , Zakharova I. A.
Published: May 2024

A lung surfactant is a complex mixture of lipids and proteins necessary to maintain proper lung function. Drug changes play an important role in chronic lung diseases such as chronic obstructive pulmonary disease, bronchial asthma and idiopathic pulmonary fibrosis. The purpose of this article is to substantiate the use of exogenous surfactant in various respiratory diseases, based on the analysis of publications in domestic and international medical journals, as well as their own experience of application in real clinical practice. This review primarily discusses the contribution of pulmonary surfactants to maintaining homeostasis of the respiratory system; optimal delivery routes; differences between natural and synthetic surfactant; diseases associated with impaired surfactant production, such as idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, acute respiratory distress syndrome, pulmonary alveolar proteinosis, cystic fibrosis. Special attention is paid to the immunological properties of specific proteins of surfactants A and D, their effect on protection against respiratory viral infection. Data on the direct effect of exogenous surfactant on pulmonary function, an increase in post-bronchodilation FEV1 and FVC are presented. Special attention is paid to the use of surfactant in the new coronavirus infection COVID-19. Pharmacological and therapeutic strategies to improve pulmonary surfactant dysfunction can prevent alveolar collapse, reduce the proinflammatory response, and limit viral infection. Currently, the use of surfactant preparations for the treatment of various respiratory diseases is being studied in several clinical trials, which will significantly revise the understanding of the therapeutic possibilities of an exogenous surfactant and expand its application areas.
Complicated pregnancy and perinatal outcomes in women with type 1 and type 2 diabetes mellitus
Authors: Dudareva Yu. A. , Seroshtanova D. N.
Published: May 2024

Introduction. Pregestational diabetes mellitus during pregnancy negatively affects the course and outcome of pregnancy, primarily due to the increase in obstetric complications, perinatal morbidity and mortality.

Aim. Assessment of obstetric and perinatal complications and the possibility of predicting adverse perinatal outcomes in women with type 1 and type 2 diabetes mellitus.

Materials and methods. The study included 132 women. The main group consisted of 79 pregnant women, 41 of them with type 1 diabetes mellitus (group 1A) and 38 with type 2 diabetes mellitus (group 1B) and 53 patients – the control group, whose pregnancy was not accompanied by a violation of the mother’s carbohydrate metabolism.

Results. Analysis of the course of pregnancy showed that the complicated course of pregnancy is associated mainly with the presence of placental dysfunction in women with diabetes mellitus, which was detected in 94.9% of cases, in contrast to the control group – 33.3%; p = 0,0001. Polyhydramnios (13.9 ± 1.1%; p = 0.005), diabetic fetopathy (13.9 ± 1.1%; p = 0.005), intrauterine fetal hypoxia requiring maternal assistance was detected in women with diabetes mellitus at 30.4% of cases (p = 0.002). Among the detected cases of cerebral ischemia in newborns born to mothers with type 1 diabetes, 43.5 ± 4.2% of women were prematurely delivered according to indications of fetal distress, and 26.1 ± 3.7% were due to decompensated diabetes in the mother. In women with type 2 diabetes mellitus, delivery according to indications from the fetus among children born with CI – 33.3 ± 3.8 percentage (p = 0.598), cases due to decompensation of the underlying disease and early delivery were not detected (p = 0.001).

Conclusions. Thus, complicated pregnancy and adverse perinatal outcomes, despite recent advances in obstetrics and endocrinology, are typical for pregnant women with type 1 and type 2 diabetes mellitus. The management and observation of such patients should be carried out by a multidisciplinary team of specialists specialized in this problem, from the preconception stage to the time of delivery.
Adherence to osteoarthritis therapy: problems and solutions
Authors: Filatova Yu. S. , Zheltkevich O. V. , Solodchuk O. N. , Kramskaya L. A.
Published: May 2024

The article discusses the issues of adherence to therapy in general and adherence to therapy in patients with osteoarthritis. The importance of adherence to the drug regimen in patients with chronic diseases determines not only the success of the prescribed therapy, but also the economic costs of treatment. Among the factors determining the success of adherence, some authors single out the personality of the doctor, the characteristics of the patient’s behavior and the course of his disease. Also, a significant role in the continuation of taking medications is the fear of patients of possible side effects. Among patients with osteoarthritis, according to research data, there was a low adherence to both lifestyle modification (following recommendations for non-drug treatment) and taking medications. When studying a number of social aspects of adherence to therapy in patients with OA, a high influence of the environment was found. According to research data, the factors influencing low adherence to therapy in patients with OA are age, severity of pain, and trust in the doctor. High comorbidity also makes a big contribution to the adherence to therapy in patients with OA, which increases the number of medications taken by patients. To reduce the risk of abandoning therapy with symptom-modifying delayed-action drugs for the treatment of OA and increase adherence, especially in comorbid patients, a personalized approach and discussion (with emphasis on the effectiveness and safety of prescribed drugs) with the patient is necessary. Choosing to prescribe injectable forms of drugs from the group of symptom-modifying delayed-action drugs will increase adherence to therapy due to the peculiarities of the course of their use.
The role of whole metagenomic sequencing in the chronic endometritis diagnosis and treatment
Authors: Bakhtiyarov K. R. , Zueva A. S. , Dudurich V. V. , Radionova V. V. , Kapyrina T. D.
Published: May 2024

Whole metagenomic sequencing is a new field of genomics and bioinformatics based on the construction of a random nucleotide sequence from the total DNA of a sample followed by deep sequencing. One of the advantages of this method, compared to culture and 16S rRNA sequencing, is the possibility of obtaining a more complete characterization of the biodiversity of the studied sample with the identification of unculturable microorganisms from the kingdoms of bacteria, archaea, viruses, fungi, and protozoa. Despite the high cost and complexity of technical implementation, whole metagenomic sequencing is increasingly used in clinical studies to investigate changes in the uterine and vaginal microbiomes in inflammatory diseases of the female reproductive system organs. The use of whole metagenomic sequencing within the framework of complex diagnostics of chronic endometritis is promising. Compared to traditional diagnostic methods (histologic, hysteroscopic, immunohistochemical and microbiologic studies), this method allows not only to identify potential causative agents of the disease at the species level, but also to determine the genes of drug resistance in microorganisms, which is especially important against the background of widespread strengthening of antibiotic resistance. In addition, some authors point to the relationship of bacterial vaginosis pathogens with the development of chronic endometritis, which should also be taken into account when prescribing antibacterial drugs. In this regard, it is highly relevant to study the biodiversity of uterine and vaginal microbiomes using whole metagenomic sequencing. This will allow not only to avoid such serious complications as premature birth, habitual pregnancy failure, failure of embryo implantation after IVF cycles, infertility, but also to develop adequate tactics of etiotropic therapy of chronic endometritis.
Aminobenzoic acid and prospects of its use in ophthalmology practice
Authors: Korneeva A. V. , Loskutov I. A.
Published: May 2024

Aminobenzoic acid is a biologically active substance widespread in nature, which has a wide range of therapeutic applications as an antiviral, antibacterial, antioxidant, antimutagenic, anticoagulant, fibrinolytic, immunomodulatory, radioprotective agent. As an interferon inducer it has been used for many years in mono- and complex therapy of viral eye lesions: conjunctivitis, keratoconjunctivitis, keratouveitis, including those caused by the herpes virus (Herpes simplex, Herpes zoster), adenoviruses; keratopathies of infectious, post-traumatic and postoperative origin. Taking into account the available information, a new drug has been registered and introduced into clinical practice, the main active ingredient of which is 0.007% aminobenzoic acid – Exinta. However, a number of studies have also shown the effectiveness of аminobenzoic acid in the treatment of neurodegenerative eye diseases by reducing the intensity of oxidative damage by lipid peroxidation products, as well as increasing the activity of transport adenosine triphosphatases in eye tissues. Based on the results obtained, it is recommended to use a 0.007% aminobenzoic acid solution not only for the treatment of viral eye diseases as an interferon inducer, but also in the treatment of uveitis, burns and eye injuries, retinal dystrophies, retinopathy, after ophthalmological operations, inflammatory and dystrophic diseases of the cornea, for keratopathies of various origins, for accommodation disorders, etc. In the given clinical example, 0.007% aminobenzoic acid showed its effectiveness in the lingering course of chronic conjunctivitis in the background of the low effectiveness of other drugs, where with the help of monotherapy it was possible to achieve clinical recovery.
Urate-lowering therapy for gout: Difficulties in goal achieving the and ways to overcome
Authors: Krasivina I. G. , Dolgova L. N. , Dolgov N. V.
Published: May 2024

Introduction. The effectiveness of gout treatment is assured by achieving a serum uric acid target level, which is currently accepted by most national clinical guidelines and consensus as < 360 µmol/L. Achievement of therapy goals is ensured by modification of patients’ lifestyle and adequate prescription of urate-reducing therapy and often involves a number of difficulties

Aim. To analyze the frequency of prescription and success of urate-reducing therapy in patients with gout over a five-year observation period in real clinical practice.

Materials and methods. Retrospective evaluation of the management of 104 patients (72 men and 32 women) with gout diagnosed for the first time in 2018, followed up to and including 2023. We analyzed the adequacy of urate-reducing therapy prescription, frequency of arthritis exacerbations, and presence of comorbidities in subgroups achieving or not achieving uric acid target level < 360 µmol/L.

Results. 26 people achieved uric acid target level, with a comparable ratio of men and female in subgroups of achieving or not achieving. The fact of achieving uric acid target level was recorded during the first year of observation and was maintained subsequently. Prescription of urate-reducing therapy was registered in 42% of the group, but in only 41% of them it was adequate. Even with adequate prescription of allopurinol, 1/3 of the patients did not achieve uric acid target level. The prescription of an alternative uricostatic agent, febuxostat, was noted in only 9% of patients.

Conclusions. Achieving total control in gout in real clinical practice noted in 25%, and urate-reducing therapy was prescribed in 42% of patients. Urate-lowering therapy was prescribed adequate in less than 1/2 of patients. Alternative uricostatic to allopurinol febuxostat was prescribed in less than 1/10 of patients. Opportunity achievement of the urate-reducing therapy goal was determined within the first year from diagnosis gout. If the uric acid target level is not reached within a given period of time, it is necessary analyze the reasons for failure and prescribe or intensify urate-reducing therapy.
Direct Methylation Method for Quantification of Fatty Acids in Lyophilized Human Milk by Gas Chromatography with Flame Ionization Detector
Authors: Souza Patrícia , Santos Patrícia , Ponhozi Isadora , Cruz Victor Hugo , Pizzo Jessica , Alves Eloize , Santos Oscar , Visentainer Jesuí
Published: May 2024

This study aims to propose a new method for derivatizing fatty acids (FAs) from human milk (HM), eliminating the lipid extraction step, and simplifying the preparation for gas chromatography with a flame ionization detection (GC-FID) analysis to quantify the FAs. The Design Expert software optimized the reaction times, concentrations, and sample amount. The proposed method (PM) was validated for lyophilized HM and results for the figures of merit for precision in relative standard deviation (RSD) (RSDintra-day 1.34-4.03% and RSDinter-day 2.08-5.16%), accuracy (99.87-102.16%), and robustness are within a linear range of 3 to 38% lipids in HM samples. The atmospheric solids analysis probe tandem mass spectrometry (ASAP-MS/MS) technique confirmed the efficiency of PM by expressing the molecular composition of triacylglycerol formed by FAs from the GC-FID technique. The PM requires a small sample size and conducts derivatization directly in the sample matrix, minimizing extraction errors.
Geo-electrostratigraphic assessment of aquifer potential, protectivity, and pliable level of vulnerability within a coastal milieu
Authors: Udosen Ndifreke I. , Ekanem Aniekan M. , George Nyakno J. , Thomas Jewel E.
Published: May 2024

Geo-electro stratigraphic assessments of aquifer potentiality, protectivity, and pliable level of vulnerability within a coastal milieu were undertaken with geo-electrical technology. The vertical electrical soundings were undertaken at 20 locations and the 2D electrical resistivity tomography surveys were undertaken at five locations within the study area. Results obtained from these geo-electrical surveys coupled with hydro-geophysical investigations within the area indicated the presence of four geo-electric layers: motley topsoil, sandy clay, fine sand, and coarse sand. The geo-stratigraphic data assessed groundwater potentiality, protectivity, and vulnerability to contamination with measures of transverse resistance, hydraulic conductivity, transmissivity, hydraulic diffusivity, aquifer storativity, and longitudinal conductance. Geo-hydraulic characterization indicated mean aquifer resistivity of 554.6 Ωm, mean aquifer conductivity of 0.0004 S/m, mean longitudinal conductance of 0.67 Ω−1, mean transverse resistance of 5601.7 Ωm2, mean hydraulic conductivity of 3.5 m/day, mean transmissivity of 283 m2/day, mean storativity of 0.0002, and mean hydraulic diffusivity of 1 × 105 m2/day. The results indicated that the region's groundwater potential ranged from medium to high. Longitudinal conductance values indicated that the aquifer protective capacity ranged from moderate to poor. Geo-electrical technology was therefore found to be an effective methodology for delineating aquifer potentiality, protectivity, and vulnerability within the vulnerable coastal aquifer system.
NIEJAWNE POSTĘPOWANIA SĄDOWOADMINISTRACYJNE W DOBIE PANDEMII COVID-19 A REALIZACJA PRAWA DO SĄDU
Authors: Smarż Joanna
Published: May 2024

Zasada jawności postępowania sądowego, gwarantowana konstytucyjnie, jako element prawa do sądu, jest jedną z podstawowych zasad demokratycznego państwa prawa. Niestety pandemia COVID-19 zdestabilizowała funkcjonowanie organów wymiaru sprawiedliwości oraz wymagała podjęcia pilnych decyzji wpływających na ich funkcjonowanie. Początkowo zawieszono bowiem rozpatrywanie spraw, z wyjątkiem spraw pilnych. Z czasem zaś wprowadzono możliwość rozpoznania spraw administracyjnych na posiedzeniu niejawnym. Nowe rozwiązania istotnie modyfikują dotychczasowe zasady rozpoznawania spraw administracyjnych, rozszerzając zakres sytuacji dopuszczających rozpoznanie sprawy na posiedzeniu niejawnym, wykluczając jawność zewnętrzną i ograniczając jawność wewnętrzną. Rozwiązania te, mimo że miały zapewnić ciągłość działania sądów administracyjnych, rodzą pytania o zapewnienie realizacji prawa do sądu.
A Base Nacional Comum Curricular e a Inclusão na Educação Física Escolar
Authors: Costa e Silva João Anttonio , Pitanga Vianna Aurélio , Foganholi Claudia , Moreira Antunes Marcelo
Published: May 2024

O estudo objetiva realizar uma análise sobre como a Inclusão é abordada pelos documentos oficiais em especial pela Base Nacional Comum Curricular (BNCC). Metodologicamente se constitui como uma análise documental de fontes oficiais da educação brasileira. Esta análise permite entender de que forma o tema é tratado nos documentos oficiais, possíveis lacunas existentes e níveis de profundidade. Realiza ainda diálogo entre a literatura e os documentos consultados articulando com o tema da inclusão. Como resultado, pode-se perceber que a Inclusão é tratada de maneira superficial, por vezes ausente nos textos oficiais da educação básica. Na BNCC o tema não é abordado como forma de intervenção, nem como conteúdo curricular a ser trabalhado nos diferentes níveis de escolaridade. Esse cenário indica a necessidade de se discutir a Inclusão como tema e conteúdo curricular na escola norteando as ações pedagógicas.
Leitura das narrativas de ciclos de vida profissional de professores na concepção de Huberman
Authors: De Oliveira da Fonseca Santos Rosiane , Oliveira Rabelo Amanda
Published: May 2024

Neste trabalho analisamos os desafios enfrentados na carreira docente, desde o “choque de realidade” e ao longo do tempo em seu desenvolvimento profissional docente, entrelaçado à construção e reconstrução da identidade docente. Analisamos os ciclos de vida profissional de professores na concepção de Huberman (1995) além de dialogar com outros autores sobre a temática. Realizamos a pesquisa com três professores do Curso Normal, com diferentes tempos de magistério, de uma mesma escola de Trajano de Moraes-RJ. A metodologia é de abordagem investigação narrativa, centrada no método qualitativo, exploratório-descritivo. As informações foram construídas através de entrevistas semiestruturadas, e as análises das narrativas em diálogo com o referencial teórico, através da modalidade de pesquisa investigação narrativa, através da cognição narrativa e a cognição paradigmática. Analisando os dados da pesquisa, conhecemos melhor, as trajetórias dos professores, percepções sobre a docência enquanto atuação profissional, desafios enfrentados e experiências vividas na formação do ser docente.
Violência por Parceiro Íntimo em Relações Homossexuais Masculinas
Authors: Souza Daniel Cerdeira de , Beiras Adriano
Published: May 2024

Analisamos os significados da VPI nas relações íntimas de um grupo de homens que mantém relações homossexuais. Trata-se de uma pesquisa qualitativa, onde oito homens que mantém relações íntimas com outros homens foram entrevistados. Os dados foram analisados pela Análise Temática e construímos quatro temas: Performatividade de Masculinidades; Intergeracionalidade; Sexualidade; Disputa de poder. As relações aqui analisadas foram permeadas por disputas de poder baseadas gênero, raça e classe, que culminaram em VPI. Observamos que os esteriótipos de gênero deram inteligibilidade as violências sexuais. Os participantes da pesquisa, principalmente aqueles que não performatizam os estereótipos de masculinidade esperados, foram expostos a uma carga de estresse social intensa que teve reflexo nas situações de VPI relatadas. Concluímos que a interseccionalidade entre diversos fatores sociais dificulta que homens se reconheçam como envolvidos em tais situações.
Treinamento em Ressuscitação Cardiopulmonar Extra-Hospitalar. Comparação Entre Alunos da Área de Humanas e Saúde.
Authors: Cardoso dos Santos Marcos Antônio , Marques dos Santos Sara Cristine , Saldanha dos Santos Pedro Augusto , Dos Santos Silva Marco Aurélio , Tavares Lima Trajano Eduardo , Picone Borges de Aragão Ivana
Published: May 2024

A parada cardiorrespiratória (PCR) é um evento súbito, com elevada mortalidade, podendo ser revertida em caso de socorro imediato, com técnicas corretas de reanimação cardiopulmonar (RCP).  Objetivo foi avaliar o conhecimento e capacitar os alunos das áreas de humanas e saúde sobre técnicas de RCP. Projeto de pesquisa “Avaliação do conhecimento em técnicas de RCP”, Comitê de Ética em Pesquisa 5.902.883, entre 2022 e 2023, com aplicação de questionário antes e após capacitação em RCP, segundo a American Heart Association (AHA). Análise estatística utilizando o teste Qui-quadrado de Pearson ou o teste Exato de Fisher, margem de erro para significância de 5%.  Ambos os cursos avaliados demonstraram pouco conhecimento acerca do suporte básico de vida na fase pré-capacitação. Após o treinamento, houve aumento significativo do conhecimento ambos os cursos.  A capacitação é uma forma de aumentar o conhecimento e engajamentos do público para atuar frente a emergências extra hospitalares.
Navegação em oncologia: atuação do enfermeiro navegador na assistência ao paciente com câncer
Authors: Araújo Jessica dos Santos , Abreu Wanessa Oliveira de , Santos Daiana Alves dos , Santos Adyverson Gomes dos , Paixão Wallace Henrique Pinho da , Silva Jorge Luiz Lima da
Published: May 2024

Introdução: as doenças crônicas não transmissíveis (DCNT) são mundialmente as mais incidentes com destaque do câncer, que demanda tratamento contínuo e integral, configurando a navegação em oncologia. Metodologia: refere-se a uma revisão integrativa de literatura, ou seja, uma interpelação que objetiva a junção de reflexões com base na produção de uma perspectiva sobre um determinado tema em estudo.   Resultados: a navegação do paciente é organizada em nove princípios teóricos que auxiliam o enfermeiro em suas atribuições voltadas à oncologia, estabelecendo um perfil de coordenação, liderança, comunicação, educação em saúde, orientação e informação. Ademais, o usuário de saúde acometido pelo câncer é parte integrante desse processo de recuperação e promoção da saúde, à medida que estabelece uma conexão com o profissional. Discussão: em relação às lacunas no cuidado oncológico e seus efeitos no plano de tratamento, os enfermeiros navegadores têm como função o gerenciamento do cuidado para pacientes recentemente diagnosticados com câncer.   Considerações finais: infere-se, portanto, que a navegação em oncologia com a pessoa com câncer é caracterizada pelo vínculo profissional/paciente e no abastecimento de informações sobre a doença a fim de propiciar o enfrentamento por parte do paciente. 
Palavras-chave: Enfermagem; Navegação de Pacientes; Oncologia.
COVID-19 - Revisão das manifestações cardiovasculares
Authors: Francisco Gabriel Katiuscia de Oliveira , Paz Chao Bárbara Mendez , Ivanski Fernanda , Fermino Bárbara Luisa , Nascimento Marcieli Borba do , Carraro Emerson
Published: May 2024

Introdução: A Doença do Coronavírus de 2019 (COVID-19) progrediu rapidamente para uma emergência de saúde mundial. No entanto inicialmente suas complicações eram associadas ao sistema respiratório, muito ainda é desconhecido acerca das suas manifestações extrapulmonares. Deste modo, o estudo  buscou compreender a interação entre a COVID-19 e manifestações cardíacas. Materiais e Métodos: Estudo descritivo do tipo revisão, realizada de acordo com a estratégia PICOS para elucidar o objetivo do trabalho, entre os meses de janeiro a maio de 2023. Resultados e Discussão: Foram incluídos 7 estudos, de 2020 a 2022, considerados pertinentes de acordo com os critérios de elegibilidade segundo o objetivo do presente trabalho. As complicações cardíacas associadas à COVID-19 incluem lesão miocárdica, insuficiência cardíaca, arritmias, miocardite, infarto agudo do miocárdio, associados à importantes alterações em exames laboratoriais bem como à comorbidades. Considerações finais: Ficou evidente a relevância da problemática no contexto da COVID-19, bem como se ressalta a necessidade de mais estudos, a fim de que os mecanismos que levam as alterações cardíacas possam ser mais bem elucidados e dessa forma contribuírem para a prática clínica e melhoria da qualidade de vida dos pacientes acometidos.
Palavras-Chave: COVID-19; Diagnóstico; Manifestações Cardíacas; Complicações Cardíacas.
A construção de um protocolo de cuidado de enfermagem frente aos usuários de drogas psicoativas no serviço de emergência
Authors: Barbosa Diogo Jacintho , Lemos Danielly de Castro , Barbosa Shenia Teixeira , Souza Giovana Nascimento de , Teixeira Matheus de Paula , Soares Thalia Brenda Ribeiro , Pessanha Rayanna Gabriela Brito Capucho
Published: May 2024

Este estudo teve por objetivos criar um plano de cuidados em enfermagem frente as pessoas que fazem uso de drogas psicoativas com base no relato de experiência do atendimento em unidades de emergência pelos alunos da Liga Acadêmica de Urgência e Emergência. Método: A pesquisa se desenvolveu partir da observação dos atendimentos ocorridos em um Centro de Atenção Psicossocial localizado na cidade e no estado do Rio de Janeiro. A pesquisa foi conduzida pela Liga Acadêmica de Urgência e Emergência da Universidade Estácio de Sá. Resultados: Foi realizada a observação clínica de dois atendimentos realizados no CAPS. Discussão: Após a observação dos casos atendidos, foi possível observar que os clientes para além das questões relacionadas no atendimento, estes apresentavam também problemas relacionados ao consumo de substâncias psicoativas, o que possibilitou a criação de um protocolo clínico de atendimento. Conclusões: É fundamental que os usuários de drogas sejam tratados com respeito e dignidade em todos os momentos do atendimento. A equipe de enfermagem deve evitar qualquer tipo de estigmatização ou preconceito em relação essas pessoas.
Palavras-Chave: Drogas psicoativas; Enfermagem de emergência; Experiência de enfermagem; Protocolo de cuidado; Usuários de drogas.
Telemonitoramento do paciente em longa espera para cirurgia eletiva: expectativa versus realidade
Authors: Pereira Adriana , Silva Rose Mary Costa Rosa Andrade , Pereira Eliane  Ramos , Fabri Janaina Mengal Gomes
Published: May 2024

Dados do Ministério da Saúde informam que chega a 679 mil o número de procedimentos eletivos em espera. Muitas das vezes um tempo longo de espera pode ocasionar complicações do caso inicialmente apresentado para indicação cirúrgica, comprometimento de outras questões de saúde, além de impacto na vida social e emocional do paciente. Objetivo: demonstrar se existe programa de telemonitoramento, no período pré- operatório das questões de saúde dos pacientes em longa espera por cirurgias eletivas, no Brasil. Metodologia: revisão integrativa de literatura a partir do problema identificado, promovendo avaliação crítica que contemple uma síntese das evidências disponíveis. Resultados: foram analisados 10 artigos de publicações entre os anos de 2017 e 2021. sendo a maioria (90%) dos estudos publicada entre 2018 e 2021. O nível de evidência predominante foi o NE2 (n = 8), correspondendo a 80% dos estudos. Discussão: uma das etapas essenciais ao sucesso da cirurgia é a avaliação e o acompanhamento na fase pré-operatória, sendo possível avaliar a história clínica do paciente e implementar ações individualizadas, contemplando a educação em saúde, para acompanhamento adequado do quadro geral e de possíveis comorbidades associadas. Conclusão: não foram identificados números relevantes de estudos que abordem a temática de acompanhamento de pacientes em longa espera por cirurgias eletivas. Contudo, estudos no Brasil e no mundo demonstram que o longo tempo de espera tem reflexo direto na qualidade de vida e manutenção da saúde dos pacientes. Consideramos de grande relevância que novos estudos ocorram e que sejam propositivos para solução do problema em questão.
Palavras-Chave: Procedimentos Cirúrgicos Eletivos; Telemonitoramento; Período Pré Operatório.
Assessment of Quality of Pain and Patient Satisfaction using ASSIST Questionnaire Following Intraperitoneal Instillation of Ropivacaine Compared with the Addition of Adjuncts Ketamine versus Dexmedetomidine in Laparoscopic Cholecystectomy patients
Authors:   Department of Anaesthesiology, Critical Care and Pain Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi India, Kapoor Ruchi , Dua Steffi ,   Department of Anaesthesiology, Pain Medicine & Critical Care, Trauma Centre, All India Institute of Medical Sciences, New Delhi, India, Saxena Ashok Kumar ,   Department of Anaesthesiology, Critical Care and Pain Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India
Published: May 2024

Background: Evaluation of patient satisfaction score and to assess quality of pain relief following intraperitoneal instillation of Ropivacaine with adjuncts Dexmedetomidine vs Ketamine using modified version of revised APS-POQ in patients undergoing laparoscopic cholecystectomy. Methods: Sixty patients undergoing laparoscopic cholecystectomy were randomised into three groups of 20 each and received Ropivacaine 0.2 % (group R), Ropivacaine 0.2 % with Dexmedetomidine 0.7µg/ kg (group RD) and Ropivacaine with Ketamine 0.5 mg/kg (group RK) in a total volume of 40 ml. Pain severity, subjective pain complaints, pain interference in physical activity, and patient's and caregiver's satisfaction were evaluated using a modified version of the revised APS-POQ at 24 hours postoperatively. Result: Mean pain scores for worst pain were observed to be least in Group RD, with mean values being 1.75±1.743, followed by 5.45±1.701 in Group R and mean value of 5.60±0.754 in Group RK. Mean patient satisfaction scores were found to be highest in Group RD (94.00±8.826), followed by Group R (80.00±15.218), and least in Group RK (78.50±12.258). This difference was observed to be statistically significant (p<0.05) in all groups. Primary care physicians caring for the RD group had higher satisfaction scores (9.40±0.883) compared to Group RK (7.85±1.226) and Group R (8.05±1.468) Conclusion: Quality of pain relief improved the best with Dexmedetomidine followed by Ketamine and least when Ropivacaine used alone for intraperitoneal instillation. The overall patients' satisfaction was found to be more with Ropivacaine with Dexmedetomidine when compared to Ropivacaine alone or with Ketamine
Dexmedetomidine as an Ambulatory Sedation Agent for Abdominal MRI in Patients with Suspected Pheochromocytoma
Authors:   Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Brawijaya University, Dr.Saiful Anwar Hospital, Malang, Indonesia, Iradat Prataganta , Vitraludyono Rudy ,   Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Brawijaya University, Dr.Saiful Anwar Hospital, Malang, Indonesia Indonesia, Yupono Karmini ,   Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Brawijaya University, Dr.Saiful Anwar Hospital, Malang, Indonesia Indonesia
Published: May 2024

Background: Pheochromocytoma is a vascular tumor of chromaffin tissue, most commonly at the adrenal medulla, that produces and secretes norepinephrine and epinephrine and is a tumor that secretes catecholamines. Magnetic resonance imaging (MRI) is often used to provide clinical data and remains challenging in pediatrics. We present anesthesia management for abdominal MRI in pediatric patients with suspected pheochromocytoma. Case: A 12-year-old child weighing 25 kg with a diagnosis of suspected pheochromocytoma will have an abdominal MRI for diagnosis with sedation. Intravenous sedation technique using dexmedetomidine loading dose 50 μg for 10 minutes and continued maintenance of dexmedetomidine dose 17.5 μg/hour. Durante's MRI showed stable hemodynamics. Post-MRI of the abdomen, monitoring, and evaluation were carried out in the conscious recovery room and found no complications. Conclusion: The use of dexmedetomidine as a sedation agent in patients with suspected pheochromocytoma generally shows stable hemodynamics in the absence of signs of catecholamine spikes.
Pendugaan Umur Simpan Tepung Salak (Salacca zalacca) Menggunakan Metode Accelerated Shelf Life Test (ASLT) Pendekatan Kadar Air Kritis
Authors:   Universitas Ahmad Dahlan, Swastika Aprellianti Dwi , Juwitaningtyas Titisari ,   Universitas Ahmad Dahlan
Published: May 2024

Tepung salak merupakan produk alternatif dalam meningkatkan nilai jual dan memberikan umur simpan yang lebih lama terhadap buah salak. Salah satu UMKM yang memproduksi tepung salak yaitu Sarisa Merapi, tetapi masalah yang dihadapi oleh UMKM tersebut yaitu berkaitan dengan umur simpan produk yang masih berdasarkan perkiraan dengan menyimpan produk pada kondisi normal sehari-hari sampai produk dianggap tidak layak konsumsi dan sudah mengalami kerusakan fisik. Oleh karena itu penelitian ini bertujuan untuk mengetahui umur simpan tepung salak dengan menggunakan metode Accelerated Shelf Life Test (ASLT) pendekatan kadar air kritis. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) 1 faktor yaitu kelembaban relatif (RH). Pengkondisian RH menggunakan beberapa larutan garam jenuh yaitu MgCl2 (32%), Mg(NO3)2 (54%), NaCl (75%), KCl (84%) dan K2SO4 (97%). Setiap perlakuan dilakukan 3 kali pengulangan yang diawali dengan penentuan kadar air awal, kadar air kritis, kadar air kesetimbangan, slope kurva isotermis, dan penentuan umur simpan tepung salak yang dianalisis menggunakan persamaan Labuza. Hasil penelitian menunjukkan bahwa kadar air kritis tepung salak adalah 0.0784 g H2O/g padatan. Kurva isotermis sorpsi air (ISA) membentuk kurva sigmoid dengan persamaan yang diperoleh y= 0.1025x + 0.0051 dan R2= 0.9797. Hasil perhitungan pendugaan umur simpan tepung salak yang disimpan dalam kemasan polypropilen dengan ketebalan 0,08 mm pada RH 32, 54, 75, 84, dan 97% secara berturut-turut yaitu 325, 317, 311, 175, dan 114 hari.
Perbandingan Efektivitas Fitoremediasi Dalam Mereduksi BOD dan COD (Studi Kasus: Industri Batik Alam, Pasuruan)
Authors:   Universitas Trisakti, Putri Sheilla Megagupita , Widiatmono Bambang Rahadi ,   Universitas Trisakti, Sari Emelia ,   Universitas Trisakti
Published: May 2024

Pembangunan industri batik memberikan dampak terhadap lingkungan, produk akhir dalam proses tersebut menghasilkan limbah cair yang mengandung logam dan bahan organik. Teknik fitoremediasi pada penelitian ini menggunakan tanaman Eceng Gondok (Eichornia crassipes) dan Kayu Apu (Salvinia cucullata) untuk mereduksi BOD dan COD pada Industri Griya Alam Batik Pasuruan. Metode yang digunakan adalah metode eksperimen dengan Rancangan Acak Lengkap (RAL) pada faktorial 2x3. Penelitian ini bertujuan untuk menentukan konsentrasi limbah cair batik yang efektif dalam proses fitoremediasi pada tanaman eceng gondok dan kayu apu dalam mereduksi BOD dan COD. Konsentrasi air limbah yang digunakan antara lain konsentrasi 0% (sebagai kontrol), konsentrasi 20% dan konsentrasi 40% pada masing – masing jenis tanaman. Menurut hasil penelitian Konsentrasi 20% adalah konsentrasi paling efektif dalam proses fitoremediasi. BOD pada tanaman Eceng Gondok dari 305.36 menjadi 199.27 mg.L-1, sedangkan nilai BOD tanaman Kayu Apu dari 305.36 menjadi 229.95 mg.L-1, COD pada tanaman eceng gondok dari 659.75 menjadi 505.18 mg.L-1, sedangkan COD tanaman Kayu Apu dari 659.75 menjadi 519.93 mg.L-1. sehingga dapat disimpulkan bahwa tanaman eceng gondok lebih efektif dalam mereduksi BOD dan COD air limbah batik alam.
Impact of economic growth, village funds, and poverty on human development in Indonesia: An analytical study from 2015 to 2022
Authors:   Department of Business Administration, Atma Jaya Catholic University of Indonesia, South Jakarta, Indonesia, Sijabat Rosdiana
Published: May 2024

This study evaluates how a country's development of human resources, an important measure of economic and policy progress, is affected by various factors. It focuses on the impact of Gross Regional Domestic Product (GRDP), village funds, and poverty levels on the Human Development Index (HDI) across 33 provinces in Indonesia from 2015 to 2022. The aim is to enhance understanding of how promoting human development goes beyond just economic growth, highlighting the importance of addressing poverty and empowering local communities through measures like the Village Fund. By employing panel regression methods, including both static (POLS, FEM, and REM) and dynamic (FMOLS and DOLS) approaches, the study examines the influence of economic growth, village funds, and poverty on human development. The findings from static panel analysis indicate that while economic growth has a negative and significant effect on HDI, village funds positively and significantly influence it. As expected, poverty significantly and negatively affects HDI. Dynamic panel data confirms the positive and significant effect of village funds on HDI and, consistent with static analysis, shows poverty's negative impact. The implications of this research are threefold: First, it suggests that economic expansion might negatively affect HDI. Second, it highlights the importance of village funds in developing human resources, underscoring their role in provincial development financing strategies. Third, it recommends that provincial policymakers focus on reducing poverty to prevent it from hindering human development.
Identificación microbiológica de algunas cepas nativas cultivables asociadas al tracto digestivo en Panaque cochliodon
Authors: Cano-Gil Juan David , Gutiérrez-Ramírez Luz Adriana , David-Ruales Carlos A. , Pardo-Carrasco Sandra , Jaramillo-Ruiz Valentina , Arboleda-Restrepo Manuela
Published: May 2024

Objective. To characterize by microbiology the native strains associated to the intestinal tract of the species Panaque cochliodon. Materials and methods. Three adult specimens captured in the Magdalena River that were transported and sacrificed under animal welfare regulations were used. Dissection of the intestinal tract was performed, obtaining samples for microbiological isolation, using culture media, purifying the microorganisms, performing metabolic biochemical tests and API 20E (Biomeriux) tests for their identification. Results. Information on the microbial population structure was obtained, reporting the phylum Proteobacteria with the species: Pantoea sp, Erwinia sp, Providencia stuarti, Providencia alcalifaciens, Serratia ficaria, Citrobacter koseri and the phylum Firmicutes with the species: Bacillus sphaericus, Bacillus subtilis, Bacillus thurigiensis, Bacillus mycoides, Bacillus coagulans and Bacillus circulans. Conclusion. The predominant culturable microorganisms in P. cohliodon belong to the phylum Proteobacteria and the phylum Firmicutes.
Histological and immune response in the fish Centropomus viridis elicited by the parasite Rhabdosynochus viridisi
Authors: López-Moreno Dania , Yazdi Zeinab , Morales-Serna Francisco N. , Martínez-Brown Juan M. , Ibarra-Castro Leonardo , García-Gasca Alejandra , Abad-Rosales Selene M. , Lozano-Olvera Rodolfo , Fajer-Ávila Emma J. , Soto Esteban
Published: May 2024

Objective. To analyze histological and immunological changes in the Pacific white snook (PWS) Centropomus viridis during primary infection and re-infection with the monogenean Rhabdosynochus viridisi. Materials and methods. Samplings were performed at three timepoints (0,1, and 2). Histological alterations in gills were evaluated by the severity degree and the degree of tissue change. RT-qPCR assays were developed to investigate the expression of il1B, il8, il10, il12, il17, igM, igT, ifnγ, tnfα, tbet, hsp70, foxp3a, stat4, and cmip in gills and head kidney. Results. The prevalence of infection was 100% in challenged fish. During the primary infection, the mean intensity was 152 parasites per fish at Time 1 and 94 at Time 2, while in the reinfection, it was 367 parasites at Time 1 and 129 at Time 2. Histological analysis of gills showed fusion of the secondary lamellae, hyperplasia, infiltration of mononuclear inflammatory cells, and increase of chloride cells in both primary infections and reinfections. Only the expression of cmip in gills at Time 1 was significantly higher in reinfections than in primary infections, and the expression of il12β showed a fold-change value >100 in head kidney at Time 2 in primary infections. Conclusions. The monogenean R. viridisi may cause histological alteration in its fish host. As showed by the decrease of the intensity of infection from Time 1 to Time 2, it seems that the PWS is able to combat R. viridisi; however, our immunological analysis did not reveal strong evidence of a possible mechanism.
Multimorbidity and its Associated Factors in Korean Shift Workers: Population-Based Cross-Sectional Study
Authors: Hong Hye Chong , Kim Young Man
Published: May 2024

Background

Multimorbidity is a crucial factor that influences premature death rates, poor health, depression, quality of life, and use of health care. Approximately one-fifth of the global workforce is involved in shift work, which is associated with increased risk for several chronic diseases and multimorbidity. About 12% to 14% of wage workers in Korea are shift workers. However, the prevalence of multimorbidity and its associated factors in Korean shift workers are rarely reported.

Objective

This study aimed to assess multimorbidity prevalence, examine the factors associated with multimorbidity, and identify multimorbidity patterns among shift workers in Korea.

Methods

This study is a population-based cross-sectional study using Korea National Health and Nutrition Examination Survey data from 2016 to 2020. The study included 1704 (weighted n=2,697,228) Korean shift workers aged 19 years and older. Multimorbidity was defined as participants having 2 or more chronic diseases. Demographic and job-related variables, including regular work status, average working hours per week, and shift work type, as well as health behaviors, including BMI, smoking status, alcohol use, physical activity, and sleep duration, were included in the analysis. A survey-corrected logistic regression analysis was performed to identify factors influencing multimorbidity among the workers, and multimorbidity patterns were identified with a network analysis.

Results

The overall prevalence of multimorbidity was 13.7% (302/1704). Logistic regression indicated that age, income, regular work, and obesity were significant factors influencing multimorbidity. Network analysis results revealed that chronic diseases clustered into three groups: (1) cardiometabolic multimorbidity (hypertension, dyslipidemia, diabetes, coronary heart disease, and stroke), (2) musculoskeletal multimorbidity (arthritis and osteoporosis), and (3) unclassified diseases (depression, chronic liver disease, thyroid disease, asthma, cancer, and chronic kidney disease).

Conclusions

The findings revealed that several socioeconomic and behavioral factors were associated with multimorbidity among shift workers, indicating the need for policy development related to work schedule modification. Further organization-level screening and intervention programs are needed to prevent and manage multimorbidity among shift workers. We also recommend longitudinal studies to confirm the effects of job-related factors and health behaviors on multimorbidity among shift workers in the future.
Web-Based Group Conversational Intervention on Cognitive Function and Comprehensive Functional Status Among Japanese Older Adults: Protocol for a 6-Month Randomized Controlled Trial
Authors: Miura Kumi Watanabe , Kudo Takashi , Otake-Matsuura Mihoko
Published: May 2024

Background

Social communication is a key factor in maintaining cognitive function and contributes to well-being in later life.

Objective

This study will examine the effects of “Photo-Integrated Conversation Moderated by Application version 2” (PICMOA-2), which is a web-based conversational intervention, on cognitive performance, frailty, and social and psychological indicators among community-dwelling older adults.

Methods

This study is a randomized controlled trial with an open-label, 2-parallel group trial and 1:1 allocation design. Community dwellers aged 65 years and older were enrolled in the trial and divided into the intervention and control groups. The intervention group receives the PICMOA-2 program, a web-based group conversation, once every 2 weeks for 6 months. The primary outcome is verbal fluency, including phonemic and semantic fluency. The secondary outcomes are other neuropsychiatric batteries, including the Mini-Mental State Examination, Logical Memory (immediate and delay), verbal paired associates, and comprehensive functional status evaluated by questionnaires, including frailty, social status, and well-being. The effect of the intervention will be examined using a mixed linear model. As a secondary aim, we will test whether the intervention effects vary with the covariates at baseline to examine the effective target attributes.

Results

Recruitment was completed in July 2023. A total of 66 participants were randomly allocated to intervention or control groups. As of January 1, 2024, the intervention is ongoing. Participants are expected to complete the intervention at the end of February 2024, and the postintervention evaluation will be conducted in March 2024.

Conclusions

This protocol outlines the randomized controlled trial study design evaluating the effect of a 6-month intervention with PICMOA-2. This study will provide evidence on the effectiveness of social interventions on cognitive function and identify effective target images for remote social intervention.

Trial Registration

UMIN Clinical Trials UMIN000050877; https://tinyurl.com/5eahsy66

International Registered Report Identifier (IRRID)

DERR1-10.2196/56608