bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Production, Inventory and Delivery Problems: Complexity and Algorithms
Authors: Li Feng , Chen Zhi-Long , Tang Lixin
Published: March 2017

We consider several integrated production, inventory, and delivery problems that arise in a number of practical settings where customer orders have pre-specified delivery time windows. These orders are first processed in a plant and then delivered to the customers by transporters (such as trains and air flights) which have fixed delivery departure times. If an order is completed but not immediately delivered by a transporter, the order is kept temporarily in inventory, which incurs an inventory cost. There is a delivery cost for delivering an order, which varies with the departure time. Given a set of orders, the objective is to find an integrated schedule for processing the orders, keeping finished orders in inventory if necessary, and delivering them to the customers such that the total inventory and delivery cost is minimum. We consider two classes of problems: where order delivery is splittable and where order delivery is nonsplittable. For each of the problems considered, we study its computational complexity by either showing that the problem is NP-hard or proposing an algorithm that can find an optimal solution. For the two most general problems, we show that any polynomial time algorithm has an arbitrarily bad worst-case performance bound, and propose combined column generation and tabu search heuristic algorithms that can find near optimal solutions for them in a reasonable computational time.

The online appendix is available at https://doi.org/10.1287/ijoc.2016.0726 .
Agreeing on What? Creating Joint Accounts of Strategic Change
Authors: Spee Paul , Jarzabkowski Paula
Published: March 2017

This paper addresses a fundamental conundrum at the heart of meaning making: How is agreement to change achieved amid multiple, coexisting meanings? This challenge is particularly salient when proposing a new strategic initiative as it introduces new meanings that must coexist with multiple prevailing meanings. Yet, prior literature on meaning-making processes places different emphases on the extent to which agreement to a new initiative requires shared meaning across diverse organizational members. We propose the concept of a joint account as the means through which an agreement to change may be achieved that accommodates multiple, coexisting meanings that satisfy diverse constituents’ vested interests. Based on the findings from an ethnographic study of a university’s strategic planning process, we develop a framework that demonstrates two different patterns in the microprocesses of meaning making. These patterns extend our understanding about the way vested interests enable or constrain the construction of a joint account. In doing so, we contribute to knowledge about resistance, ambiguity, and lack of agreement to a proposed change.
Trochleoplasty with a flexible osteochondral flap
Authors: Metcalfe A. J. , Clark D. A. , Kemp M. A. , Eldridge J. D.
Published: March 2017

Aims

The Bereiter trochleoplasty has been used in our unit for 12 years to manage recurrent patellar instability in patients with severe trochlea dysplasia. The aim of this study was to document the outcome of a large consecutive cohort of patients who have undergone this operation.

Patients and Methods

Between June 2002 and August 2013, 214 consecutive trochleoplasties were carried out in 185 patients. There were 133 women and 52 men with a mean age of 21.3 years (14 to 38). All patients were offered yearly clinical and radiological follow-up. They completed the following patient reported outcome scores (PROMs): International Knee Documentation Committee subjective scale, the Kujala score, the Western Ontario and McMaster Universities Arthritis Index score and the short-form (SF)-12.

Results

Outcomes were available for 199 trochleoplasties in 173 patients giving a 93% follow-up rate at a mean of 4.43 years (1 to 12). There were no infections or deep vein thromboses. In total, 16 patients reported further patella dislocation, giving an 8.3% rate of recurrence. There were 27 re-operations, giving a rate of re-operation of 14%. Overall, 88% were satisfied with the operation and 90% felt that their symptoms had been improved.

Conclusion

All PROMs improved significantly post-operatively except for the mental component score of the SF-12. Trochleoplasty performed using a flexible osteochondral flap is an effective treatment for recurrent patellar instability in patients with severe trochlea dysplasia and gives good results in the medium term. Cite this article: Bone Joint J 2017;99-B:344–50.
Thein vivoeffect of a porous titanium alloy flange with hydroxyapatite, silver and fibronectin coatings on soft-tissue integration of intraosseous transcutaneous amputation prostheses
Authors: Chimutengwende-Gordon M. , Pendegrass C. , Blunn G.
Published: March 2017

Aims

The Intraosseous Transcutaneous Amputation Prosthesis (ITAP) may improve quality of life for amputees by avoiding soft-tissue complications associated with socket prostheses and by improving sensory feedback and function. It relies on the formation of a seal between the soft tissues and the implant and currently has a flange with drilled holes to promote dermal attachment. Despite this, infection remains a significant risk. This study explored alternative strategies to enhance soft-tissue integration.

Materials and Methods

The effect of ITAP pins with a fully porous titanium alloy flange with interconnected pores on soft-tissue integration was investigated. The flanges were coated with fibronectin-functionalised hydroxyapatite and silver coatings, which have been shown to have an antibacterial effect, while also promoting viable fibroblast growth in vitro. The ITAP pins were implanted along the length of ovine tibias, and histological assessment was undertaken four weeks post-operatively.

Results

The porous titanium alloy flange reduced epithelial downgrowth and increased soft-tissue integration compared with the current drilled flange. The addition of coatings did not enhance these effects.

Conclusion

These results indicate that a fully porous titanium alloy flange has the potential to increase the soft-tissue seal around ITAP and reduce susceptibility to infection compared with the current design. Cite this article: Bone Joint J 2017;99-B:393–400.
Debridement and implant retention in the management of hip periprosthetic joint infection
Authors: Sendi P. , Lötscher P. O. , Kessler B. , Graber P. , Zimmerli W. , Clauss M.
Published: March 2017

Aims

To analyse the effectiveness of debridement and implant retention (DAIR) in patients with hip periprosthetic joint infection (PJI) and the relationship to patient characteristics. The outcome was evaluated in hips with confirmed PJI and a follow-up of not less than two years.

Patients and Methods

Patients in whom DAIR was performed were identified from our hip arthroplasty register (between 2004 and 2013). Adherence to criteria for DAIR was assessed according to a previously published algorithm.

Results

DAIR was performed as part of a curative procedure in 46 hips in 42 patients. The mean age was 73.2 years (44.6 to 87.7), including 20 women and 22 men. In 34 hips in 32 patients (73.9%), PJI was confirmed. In 12 hips, the criteria for PJI were not fulfilled and antibiotics stopped. In 41 (89.1%) of all hips and in 32 (94.1%) of the confirmed PJIs, all criteria for DAIR were fulfilled. In patients with exogenous PJI, DAIR was performed not more than three days after referral. In haematogenous infections, the duration of symptoms did not exceed 21 days. In 28 hips, a single debridement and in six hips two surgical debridements were required. In 28 (87.5%) of 32 patients, the total treatment duration was three months. Failure was noted in three hips (9%). Long-term follow-up results (mean 4.0 years, 1.4 to 10) were available in 30 of 34 (88.2%) confirmed PJIs. The overall successful outcome rate was 91% in 34 hips, and 90% in 30 hips with long-term follow-up results.

Conclusion

Prompt surgical treatment with DAIR, following strict diagnostic and therapeutic criteria, in patients with suspected periprosthetic joint infection, can lead to high rates of success in eradicating the infection. Cite this article: Bone Joint J 2017;99-B:330–6.
The role of the width of the forefoot in the development of Morton’s neuroma
Authors: Park Y. H. , Jeong S. M. , Choi G. W. , Kim H. J.
Published: March 2017

Aims

Morton’s neuroma is common condition of the forefoot, but its aetiology remains unclear. Our aim was to evaluate the relationship between the width of the forefoot and the development of a Morton’s neuroma.

Patients and Methods

Between January 2013 and May 2016, a total of 84 consecutive patients (17 men, 67 women) with a unilateral Morton’s neuroma were enrolled into the study. The involved and uninvolved feet of each patient were compared. A control group of patients with symptoms from the foot, but without a neuroma who were matched for age, gender, affected side, and web space location, were enrolled. The first to fifth intermetatarsal distance, intermetatarsal angle and intermetatarsal distance of involved web space on standing radiographs were assessed.

Results

The inter- and intra-observer reliability was excellent. The three parameters did not differ significantly between the involved and uninvolved feet. Neither did they differ significantly between the patients and the controls.

Conclusion

We conclude that there is no significant relationship between the width of the forefoot and the development of a Morton’s neuroma. Cite this article: Bone Joint J 2017;99-B:365–8.
Improving the accuracy of synovial fluid analysis in the diagnosis of prosthetic joint infection with simple and inexpensive biomarkers
Authors: Sousa R. , Serrano P. , Gomes Dias J. , Oliveira J. C. , Oliveira A.
Published: March 2017

Aims

The aims of this study were to increase the diagnostic accuracy of the analysis of synovial fluid in the differentiation of prosthetic joint infection (PJI) by the addition of inexpensive biomarkers such as the levels of C-reactive protein (CRP), adenosine deaminase (ADA), alpha-2-macrogloblulin (α2M) and procalcitonin.

Patients and Methods

Between January 2013 and December 2015, synovial fluid and removed implants were requested from 143 revision total joint arthroplasties. A total of 55 patients met inclusion criteria of the receipt of sufficient synovial fluid, tissue samples and removed implants for analysis. The diagnosis of PJI followed the definition from a recent International Consensus Meeting to create two groups of patients; septic and aseptic. Using receiver operating characteristic curves we determined the cutoff values and diagnostic accuracy for each marker.

Results

There were 23 PJIs and 32 patients with aseptic loosening. The levels of total leucocyte count, proportion of polymorphonuclear leucocytes (PMNs), CRP, ADA and α2M in the synovial fluid were all significantly higher in those with a PJI than in those with aseptic loosening. The levels of procalcitonin were comparable in the two groups. Cutoff values for the optimal performance in the diagnosis of infection were: total leucocyte count > 1463 cells/μL (sensitivity (Sens) 100%, specificity (Spec) 71.9%, positive predictive value (PPV) 71.9%, negative predictive value (NPV) 100%); proportion of PMNs > 81% (Sens 78.3%, Spec 75.0%, PPV 69.2%, NPV 82.8%); CRP > 6.7mg/L (Sens 78.3%, Spec 93.8%, PPV 90.0%, NPV 85.7%); ADA > 61U/L (Sens 78.3%, Spec 96.9%, PPV 94.7%, NPV 86.1%) and α2M > 958 mg/L (Sens 47.8%, Spec 96.9%, PPV 91.7%, NPV 72.1%). The addition of a raised level of CRP or ADA to the total leukocyte count increased the specificity: total leukocyte count > 1463 cells/μL and CRP > 6.7mg/L (Sens 78.3%, Spec 100%, PPV 100%, NPV 86.5%) or with ADA > 61U/L (Sens 78.3%, Spec 96.9%, PPV 94.7%, NPV 86.1%).

Conclusion

The total leucocyte count in the synovial fluid offers great negative predictive value in the diagnosis of PJI and the addition of more specific markers such as CRP and ADA improves the positive predictive value. Thus the addition of simple and inexpensive markers to the measurement of the leucocyte count in the synovial fluid may reduce the number of equivocal results which demand more expensive investigation. Cite this article: Bone Joint J 2017;99-B:351–7.
El activismo de las víctimas en contextos represivos y democráticos. Lecturas cruzadas
Authors: Vecchioli Virginia , Leal Eduardo Martinelli
Published: March 2017

Introducción al número monográfico
POTENCIAL EMPREENDEDOR DE EMPRESÁRIAS DO SETOR TURÍSTICO DE FLORIANÓPOLIS (SC)
Authors: Souza Maria José Barbosa de , Trindade Fernanda De Magalhães , Freire Robson , Lyra Franciane Reinert
Published: March 2017

O empreendedorismo feminino é um assunto de interesse na atualidade como um fator que exerce impacto nas políticas macroeconômicas dos países. Por essa razão, os estudos sobre gênero em empreendedorismo são reconhecidos por organismos internacionais que estimulam essas iniciativas,

fato que motiva o interesse de acadêmicos em pesquisar o assunto. Com o objetivo de analisar o potencial empreendedor das proprietárias de empresas do setor turístico de Florianópolis (SC), foi realizado um estudo descritivo, com 35 empresárias dessa atividade econômica. Os resultados revelaram que 68% das entrevistadas classificam-se como empreendedoras, de acordo com o instrumento desenvolvido por Carland, Carland e Hoy (1992), com média de 19,9 em um total de 33 pontos possíveis.

Os testes estatísticos comprovaram a existência de diferenças significativas entre as médias obtidas por

esse segmento e as demais entrevistadas, nos fatores traços de personalidade, postura estratégica e propensão ao risco. Porém revelou que não existe associação significativa entre potencial empreendedor e idade, escolaridade e renda da empreendedora e nem com o ramo de atividade e o tempo de existência da empresa.
A EVOLUÇÃO CONCEITUAL DA EDUCAÇÃO PARA O EMPREENDEDORISMO COMO UM CAMPO CIENTÍFICO
Authors: Oliveira Deranor Gomes
Published: March 2017

O objetivo principal deste trabalho é fornecer a evolução longitudinal da dimensão conceitual da educação para o empreendedorismo como um campo científico, bem como sua caracterização em forma de estágios entre os anos de 1990 e 2013. O estudo apoiou-se na análise de copalavras para descrever as interações temáticas invisíveis, que existem entre diferentes estágios temporais do processo evolutivo da educação para o empreendedorismo. Foi utilizada uma amostra constituída de 274 artigos ISI publicados nos principais jornais eletrônicos, internacionalmente reconhecidos pela comunidade científica, indexados à plataforma Web Of Science para uma análise bibliométrica. Os resultados revelam um campo eclético, multifacetado e interdisciplinar, passando pelos estágios: embrionário, de crescimento, de crescimento rumo à maturidade e de maturidade científica. Sugerem, ainda, ligações importantes entre a educação para o empreendedorismo, as intenções empreendedoras, a autoeficácia empreendedora, o desenvolvimento de competências empreendedoras e o contexto cultural.
ANÁLISES QUALITATIVAS NOS ESTUDOS ORGANIZACIONAIS: AS VANTAGENS NO USO DO SOFTWARE NVIVO®
Authors: Mozzato Anelise Rebelato , Grzybovski Denize , Teixeira Alex Niche
Published: March 2017

Este ensaio teórico demonstra as vantagens na utilização do software NVivo® para análise qualitativa de texto, som, foto e vídeo nos estudos organizacionais. O referido software ainda é pouco utilizado no Brasil, sobretudo nos estudos organizacionais. A utilização de softwares em pesquisas quantitativas não é novidade; entretanto, nos estudos organizacionais brasileiros nos quais, tradicionalmente, os pesquisadores adotam abordagem qualitativa dos dados, o uso tem sido limitado. Observa-se a necessidade de superação das fragilidades analíticas, em especial aquelas que derivam de um processo manual de organização e análise de dados qualitativos. Nessa lógica, as estruturas e os recursos básicos do NVivo® são aqui trabalhados, identificando-se as vantagens da sua utilização. Conclui-se que o NVivo® auxilia o pesquisador em todo o processo da pesquisa, principalmente nas análises, potencializando e intensificando alcance e profundidade, permitindo maior exploração da complexidade dos dados. Sua utilização visa agilizar e qualificar o material de análise, facilitando o processo analítico em pesquisas qualitativas nos estudos organizacionais.
Farming Muskoxen for Qiviut in Alaska: A Feasibility Study
Authors: Starr Laura , Greenberg Joshua , Rowell Janice
Published: March 2017

Muskoxen (Ovibos moschatus) have been farmed since the 1960s for their fiber, called qiviut, a luxurious and highly valued underwool that is their primary insulation during the Arctic winter. Muskoxen are uniquely adapted to the Arctic. They thrive on local forages, do not require protection from the cold, and adapt well to many traditional husbandry practices. While muskoxen can be farmed for qiviut, the question remains whether it is an economically feasible and potentially sustainable enterprise in subarctic Alaska. This feasibility study was conducted using an enterprise budget for two herd sizes, 36 and 72 muskoxen, to estimate the principal costs and model different sales combinations. Under several revenue-generating scenarios, the feasibility study indicated a potential for economic viability of an established enterprise. The most profitable scenario for either herd size was selling all the qiviut as value-added yarn, coupled with livestock sales. In the absence of selling livestock, the enterprise was profitable at either scale assuming all the qiviut was sold as yarn. Selling qiviut solely as raw fiber was not projected to break even under the model parameters. The modeled enterprise emphasized the importance of value-added goods, economies of scale, low or zero opportunity costs, and the potential of a more active livestock market.
The Battle for the National Health Service: England, Wales, and the Socialist Vision
Authors: Matthews David
Published: March 2017

England and Wales represent two very different, indeed incompatible, approaches to health care. In the former, health care has come under increasing threat from the predatory forces of privatization. In Wales, however, an explicit effort has been made to defend socialist values and formulate them for the twenty-first century, defending and expanding a system that puts the health and well-being of its citizens over profit.Click here to purchase a PDF version of this article at the Monthly Review website.
The Return of Engels
Authors: Foster John Bellamy
Published: March 2017

For decades, academics have suggested that Engels downgraded and distorted Marx's thought. Today we are at last seeing the return of Engels, whose work continues to inform the struggles and inspire the hopes that define our own time.Click here to purchase a PDF version of this article at the Monthly Review website.
Effect of group counseling on happiness, life satisfaction and positive-negative affect: A mixed method study
Authors: Bakalım Orkide , Taşdelen Karçkay Arzu
Published: March 2017

The aim of this study is to investigate the effects of a group counselling programme on happiness, life satisfaction and positive-negative affect of guidance and psychological counselling department students. The group members consisted of 28 (18 females, 10 males). Group counselling programme was applied once a week for 8 weeks.  Quantitative analysis of the study was performed using Wilcoxon Signed Rank Test and qualitative analysis was performed by content analysis of the focus group interviews and student evaluations reports.  Quantitative analysis results showed that psychological group counselling enhances the positive emotions, happiness and life satisfaction levels of the students, while it did not have any effect on the negative emotions. Qualitative analysis results demonstrated that students had both personal and professional gains in this process.
Corrosion analysis of copper T2 exposed to polluted atmospheres and study on prediction model
Authors: Zhu Zhiping , Zuo Xiandi , Ying Zhaohui
Published: March 2017

The power supply accident caused by the corrosion of metal materials in the substation has become an important issue that affects the safe operation of the power grid. The corrosion of copper T2 was the most serious. The corrosion behaviour of copper T2 in SO2- and H2S-containing atmospheric environments was investigated using electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), energy-dispersive X-ray spectrometry (EDS), and X-ray diffraction (XRD), and the nonequidistant grey GM(1,1) model was established of which the precision and forecast dependability were evaluated. Results indicated that the corrosion rate of copper in the SO2 environment increased in the early stages of corrosion and then gradually decreased at the later stages. In contrast, the corrosion rate of copper in the H2S environment slowly increased in the early stages of corrosion and then sharply increased at the later stages. The corrosion products in the SO2 environment consisted of cuprite (Cu2O) and brochantite [Cu4(OH)6SO4], whereas the corrosion products in the H2S environment were Cu2O and chalcocite (Cu2S). The mathematical model has good prediction dependability and higher forecast reliability.
Person and Knowledge: Introduction
Authors: Bergqvist Henrik , Kittilä Seppo
Published: March 2017

The relation between person and epistemicity has been a topic of investigation throughout the humanities, including linguistics, but has mostly been focused on how conceptualisations of these two notions overlap, or diverge. This paper reviews some of these conceptualisations, but also adds a finergrained picture of how they intersect in the world’s languages. Purported categories such as egophoric marking and lesser known expressions such as non-selected arguments (i.e. "ethical datives") are compared to evidentials and modals from a synchronic and diachronic perspective in order to explain how the roles of the speech-act participants as specific arguments relate to their respective function as epistemic authorities. The aim of the paper is to introduce separate contributions relating to such systems as they are found in various parts of the world.
Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic
Authors: Shi Jue , Mitchison Timothy J
Published: March 2017

Anti-mitotic cancer drugs include classic microtubule-targeting drugs, such as taxanes and vinca alkaloids, and the newer spindle-targeting drugs, such as inhibitors of the motor protein; Kinesin-5 (aka KSP, Eg5, KIF11); and Aurora-A, Aurora-B and Polo-like kinases. Microtubule-targeting drugs are among the first line of chemotherapies for a wide spectrum of cancers, but patient responses vary greatly. We still lack understanding of how these drugs achieve a favorable therapeutic index, and why individual patient responses vary. Spindle-targeting drugs have so far shown disappointing results in the clinic, but it is possible that certain patients could benefit if we understand their mechanism of action better. Pre-clinical data from both cell culture and mouse tumor models showed that the cell death response is the most variable point of the drug action. Hence, in this review we focus on current mechanistic understanding of the cell death response to anti-mitotics. We first draw on extensive results from cell culture studies, and then cross-examine them with the more limited data from animal tumor models and the clinic. We end by discussing how cell type variation in cell death response might be harnessed to improve anti-mitotic chemotherapy by better patient stratification, new drug combinations and identification of novel targets for drug development.
Concomitant CABG, Left Ventricular Restoration and Mitral Valve Repair for Ischemic Heart Disease
Authors: Zhaohua Yin , Wei Feng , Fei Xu , Jiqiang Zhang , Junzhe Du , Yangwu Song
Published: March 2017

Aim: To evaluate the effects of combined coronary artery bypass grafting (CABG), surgical left ventricular restoration (LVR), and mitral valve repair (MVP) in treating ischemic heart disease combined with mitral regurgitation; and to evaluate the different strategies of LVR and MVP.Methods: From January 2001 to December 2015, 61 consecutive patients with left ventricular aneurysm and ischemic mitral regurgitation underwent concomitant CABG, LVR and MVP. We evaluated the clinical and echocardiographic outcomes of the patients. The mean follow-up was 5.8 ± 3.3 years.Results: The operative mortality was 4.9%. One-, five-, and ten-year survival rates were 95.1%, 86.9%, and 80.3%, respectively. Mitral regurgitation, left ventricular ejection fraction (LVEF), and left ventricular end diastolic diameter (LVEDD) improved significantly after surgery (P < .001). During follow-up, 3 patients (5.2%) had moderate mitral regurgitation and 1 patient (1.9%) had severe mitral regurgitation. The clinical outcomes were not influenced by the LVR technique and MVP approach.Conclusion: Combined CABG, LVR, and MVP was effective for ischemic left ventricular aneurysm with mitral regurgitation. The procedure was associated with acceptable operative risk and clinical outcomes.
The Impact of Payer Source on Trauma Outcomes in a Pediatric Population
Authors: Lee Felecia A. , Hervey Ashley M. , Sattarin Arash , Deeds Aaron , Berg Gina M. , Molik Kimberly
Published: March 2017

OBJECTIVES:

Determine if there were differences in conclusions drawn regarding disparities in trauma outcomes based on literature-derived payer source definitions in a pediatric population.

PATIENTS AND METHODS:

Retrospective registry review of admitted pediatric trauma patients (≤17 years of age) at a level II pediatric trauma facility. Eligible patients were categorized into 3 payer source definitions: definition 1: commercially insured, Medicaid, uninsured; definition 2: insured, uninsured; definition 3: commercially insured, underinsured. Logistic regression was used to determine the influence of payer source on outcomes.

RESULTS:

Payer source was not significant in definition 1, 2, or 3 for intensive care unit length of stay (LOS), hospital LOS, medical consults, or mortality. For hospital disposition, payer source was significant in definition 1, the uninsured were 90% less likely than commercially insured to be discharged to continued care. In definition 2, the uninsured were 88% less likely than insured to be discharged to continued care. In definition 3, the underinsured were 57% less likely than commercially insured to be discharged to continued care.

CONCLUSIONS:

Differences between the literature-derived definitions were not observed and therefore conclusions drawn did not differ across definitions. The investigation demonstrated payer source was not associated with in-hospital outcomes (intensive care unit LOS, hospital LOS, medical consults, and mortality), but was with posthospital outcomes. Findings warrant future examinations on the categorization of payer source in pediatric patients and hospital disposition to gain a greater understanding of disparities related to payer source in pediatric trauma, specifically in terms of posthospital care.
Extracorporeal Membrane Oxygenation in Neonates: History and Future Directions
Authors: Parga Joanna Jean , Garg Meena
Published: March 2017

Extracorporeal membrane oxygenation (ECMO) in the neonate is a term that has been used since the 1970s for respiratory failure refractory to medical management. With its ability to increase survival, uses of ECMO have expanded and long-term morbidities continue to be under investigation. In this article, we review the history of ECMO and current methods of delivery. In addition, we explore common complications for survivors after ECMO, new technologies that may change who receives ECMO, and how we deliver this life saving treatment.
Adjunctive Therapies in Bronchopulmonary Dysplasia
Authors: Maduekwe Echezona , DeCristofaro Joseph D.
Published: March 2017

Despite the advances in the medical and respiratory support of preterm infants, chronic lung disease in these infants, widely known as bronchopulmonary dysplasia (BPD), remains one of the most challenging complications in preterm infants. The changing definitions of this disease, based on its treatment, have made management both difficult and frustrating to neonatologists. As a result, several therapies, devices, strategies, and adjunctive agents have evolved to either reduce the risk of BPD or alleviate its course. This article focuses on the pathogenesis of BPD, the adjunctive therapies used in relation to BPD, and the mechanisms of action of these adjunctive therapies.
Dyslipidemia: Current Therapies and Guidelines for Treatment
Authors: Carreras Edward T ,   Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, Polk Donna M ,   Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA
Published: March 2017

Despite significant advances in prevention and treatment, cardiovascular disease continues to be the leading cause of morbidity and mortality in the United States and worldwide. Nevertheless, the mortality from cardiovascular disease has decreased dramatically over the past few decades. Among the modifiable risk factors, dyslipidemia is a leading contributor to the development of coronary heart disease, and cholesterol-lowering treatment, primarily with statins, has been considered responsible for improvements in cardiovascular outcomes over the past 20 years. As such, physicians and researchers are frequently reevaluating the optimal approach and recommendations for cholesterol-lowering therapy for the primary prevention of cardiovascular disease. The objectives of this article are to review the evidence and efficacy of cholesterol-lowering therapies and to examine the current major societal guidelines for the management of dyslipidemia and appropriate patient selection.
Abnormal illness behavior and Internet addiction severity: The role of disease conviction, irritability, and alexithymia
Authors: Scimeca Giuseppe , Bruno Antonio , Crucitti Manuela , Conti Claudio , Quattrone Diego , Pandolfo Gianluca , Zoccali Rocco Antonio , Muscatello Maria Rosaria Anna
Published: March 2017

Background and aims

While the association between health anxiety and maladaptive Internet use is a well-established finding, no studies have been performed to examine the possible effect of abnormal illness behavior (AIB). AIB is a maladaptive manner of experiencing, evaluating, or acting in response to health and illness that is disproportionate to evident pathology. The aim of this study was to investigate the association between AIB and Internet addiction (IA) severity in a sample of Italian University students. The possible effect of alexithymia, anxiety, and depression was also taken into account.

Methods

Participants were 115 men and 163 women (mean age = 23.62 ± 4.38 years); AIB was measured via the Illness Behavior Questionnaire (IBQ), and IA severity by the Internet Addiction Test (IAT).

Results

The most powerful IBQ factor predicting IA severity scores was disease conviction. Irritability was the only emotional IBQ factor associated with IA severity. Nevertheless, disease conviction and alexithymia remained the only significant predictors of IAT scores when hierarchical regression analysis was executed.

Discussion and conclusions

Our results support previous findings showing that those characterized by health anxiety are more prone to an excessive and maladaptive use of Internet. Moreover, this study showed that irritability was the only emotional aspect of AIB predicting IA severity. This finding is consistent with the cognitive model of hypochondria, which states that cognitive factors (dysfunctional beliefs and assumptions) play a major role in the explanation of this psychopathological condition.
A petevezeték-átjárhatóság vizsgálómódszereinek összehasonlító elemzése
Authors: Lőrincz Judit , Jakab Attila , Török Péter
Published: March 2017

Abstract:

Most common organic cause of infertility is the blockage of the Fallopian tubes. Several methods were introduced to evaluate tubal patency. Hysterosalpingography is a conventional radiology procedure using contrast medium, which gives an accurate image of the uterine cavity and the Fallopian tubes, but radiation exposure is necessary. Hystero-contrast-sonography similarly examines the uterine cavity and tubal patency by ultrasonography, and it enables to detect pelvic pathology, too. Transvaginal hydrolaparoscopy is a minimal invasive direct method using endoscope introduced into the abdominal cavity through the posterior vaginal fornix, both ovaries and tubal patency can be observed. Laparoscopy is the “gold standard” procedure in the tubal testing, however it is a more invasive procedure. A cost-effective testing method is the selective tubal pertubation performed via office hysteroscopy. Recent outpatient methods to detect tubal patency have high negative predictive values and recommended to be the first choice in infertility work-up. Orv. Hetil., 2017, 158(9), 324–330.
Terápiás hypothermia alkalmazása az asphyxiás újszülöttek kezelésében – egy hazai neonatológiai centrum eredményei
Authors: Kovács Kata , Szakmár Enikő , Méder Ünőke , Kolossváry Márton , Bagyura Zsolt , Lamboy Lilla , Élő Zsuzsanna , Szabó Attila , Szabó Miklós , Jermendy Ágnes
Published: March 2017

Abstract:

Introduction and aim: We aimed to analyze patient characteristics of term neonates with hypoxic-ischemic encephalopathy treated with hypothermia at the 3rd level Neonatal Intensive Care Unit of the 1st Department of Pediatrics, Semmelweis University. Method: We conducted a retrospective cohort analysis between 2013–2015, including 97 asphyxiated neonates with HIE who received hypothermia treatment, using our in-house developed novel registry database. Results: 59.8% of neonates were born with Cesarean section and the first blood gas analysis showed a pH of 7.0 ± 0.2, pCO2 55.9 ± 27.3 mmHg, base deficit 16.7 ± 7.2 mmol/l, and lactate levels of 13.3 ± 4.7 mmol/l (x ± SD). Hypothermia treatment was started during neonatal transport in 93.7% of the cases, at 2.5 ± 0.3 hours of age. Multiorgan failure associated with the perinatal asphyxia was present in 83.2% of the patients. Patients received intensive therapy for a median of 10.8 days, 61.3% of neonates were discharged home directly, 32.2% required further hospital treatment, and 6.5% died. Conclusion: Our novel registry database allowed for a quick, user-friendly and time-efficient analysis of patient characteristics in neonates with HIE. This registry could aid institutional audit work and prospective clinical data collection. Orv. Hetil., 2017, 158(9), 331–339.
Magyar klinikai vizsgálatok sajátosságai egy nemzetközi adatbázis elemzése alapján
Authors: Tóth Tamás , Pollner Péter , Palla Gergely , Dinya Elek
Published: March 2017

Abstract:

Intorduction: The ClinicalTrials.gov website, which is operated by the US government, collects data about clinical trials. Aim: We have processed data related to Hungary by downloading from the website as XML files. Method: Most of the data describe trials performed after 2000, so we got an overview about the clinical research of the last 10 to 15 years. As the majority of the data fields are collected as free text, significant data cleaning was needed. Results: The database contained 2863 trials related to Hungary from 189 settlements. Only 20 per cent of the actual research organizations could have been identified as many times only an “id” number or a general name was given, thus this information was anonymised in many cases. Conclusion: Besides the analysis of the information obtained from this database, our study points out the relevant issues that may influence the international view of the Hungarian clinical research. Orv. Hetil., 2017, 158(9), 345–351.
Isolasi dan Karakterisasi Parsial Kolagen dari Teripang Gamma (Stichopus variegatus)
Authors: Fawzya Yusro Nuri , Chasanah Ekowati , Poernomo Achmad , Khirzin M. H.
Published: March 2017

Isolasi dan karakterisasi parsial kolagen dari teripang gamma (Stichopus variegatus) telah dilakukan. Isolasi dilakukan melalui tiga tahap yaitu preparasi, ekstraksi dan isolasi. Tahap preparasi meliputi tahapan penyiangan, pencucian dan perendaman dalam akuades, dalam alkohol, dalam larutan Tris-HCl dan etilenadiaminatetraasetat  (EDTA) dan perendaman dalam larutan natrium hidroksida (NaOH). Ekstraksi dilakukan dengan perendaman asam asetat 0,5M. Isolasi dilakukan dengan cara pengendapan menggunakan NaCl dilanjutkan proses dialisis. Isolat kolagen teripang gamma yang diperoleh memiliki rendemen sebesar 16,40% (bobot kering), nilai pH 6,08 dan derajat putih 77,02%. Gugus fungsi kolagen terdiri dari amida A (3412 cm-1), B (2929 cm-1), I (1654 cm-1), II (1554 cm-1), dan III (1239 cm-1). Asam amino utama penyusun kolagen yaitu glisin, prolin, dan alanin, masing-masing sebesar 16,88%; 6,71%; dan 6,42%. Kolagen yang dihasilkan merupakan kolagen tipe I, diduga terdiri dari 3 rantai a1 yang homolog dengan berat molekul 130,33 kDa.
PENGGUNAAN KOMBINASI PAKAN ALAMI TAHAP AWAL UNTUK PEMELIHARAAN LARVA IKAN BETUTU (Oxyeleotris marmoratus BLK. )
Authors: Chumaidi Chumaidi , Mundriyanto Honorius , Priyadi Agus
Published: March 2017

Kendala utama dalam budi daya ikan betutu adalah masih rendahnya sintasan larva sehingga menjadi problem dalam pembesarannya. Tujuan penelitian ini adalah untuk mengetahuikombinasi pakan alami tahap awal untuk pertumbuhan dan ketahanan hidup larva ikan betutu.
PENGARUH POLA PEMBERIAN PAKAN YANG BERBEDA TERHADAP PRODUKSI BENIH RAJUNGAN (Portunus pelagicus) SKALA MASSAL
Authors: Susanto Bambang , Marzuqi Muhammad , Setyadi Lrwan , Syahidah Dewi , Permana Ngurah , Haryanti Haryanti
Published: March 2017

Penelitian ini dilakukan untuk mengetahui pola pemberian pakan yang tepat dalam pemeliharaan larva rajungan skala massal. Penelitian menggunakan bak beton berbentuk bulat volume 3.000 liter yang dilengkapi dengan sistem aerasi, dan ditebar larva (zoea-1) dengan kepadatan 75 ind./L
KERAGAAN PENYAKIT BAKTERIAL IKAN NILA (Oreochromis niloticus) PADA KERAMBA JARING APUNG (KJA) DI LOKASI BERBEDA
Authors: Supriyadi Hambali , Widiyati Ani , Sunarto Agus , Prihadi Tri Heru
Published: March 2017

penelitian ini bertujuan untuk mengetahui keragaan penyakit terutama penyakit ikan bakterial pada sistem budi dayi Keramba Jaring Apung (KJA) diWaduk Cirata dan Gadjah Mungkur padamusim penghujan dan kemarau. lkan sampel berupa ikan nila (Oreochromis niloticus) diambil sampling sebanyak 40 ekor per lokasi sampling.
PENGARUH KONSENTRASI DAN RASIO LARUTAN POTASIUM HIDROKSIDA DAN RUMPUT LAUT TERHADAP MUTU KARAGINAN KERTAS
Authors: Basmal Jamal , Suryaningrum Th. Dwi , Yennie Yusma
Published: March 2017

Penelitian perbaikan kualitas karaginan kertas yang diekstrak dari Eucheuma cottonii telah dilakukan dengan melakukan variasi larutan KOH 4o/o, 60/o, dan 12o/o. Rasio E. coffonii kering berbanding larutan KOH 1 '.8 dan 1:12. Waktu pemasakan 2 jam pada kisaran suhu 70-80oC. E. cottonii yang telah dimasak tersebut kemudian diekstrak menggunakan air tawar pada suhu antara 90o-95oC selama 120 menit.
PENGUJIAN SECARA IN VIVO EFEK ANTIOKSIDATIF DARI EKSTRAK AIR RUMPUT LAUT Sargassum crassifolium
Authors: Wikanta Thamrin , Rustanti Intan K. , Rahayu Lestari
Published: March 2017

Naskah ini melaporkan hasil uji toksisitas akut (LD50) dan efek antioksidatif dari ekstrak air rumput faut Sargassum crassifolium. Penentuan LD50 menggunakan metode Weil dengan hewan percobaan mencit (Mus musculus) yang diberikan sediaan secara intraperitoneal (ip). Pada penelitian selanjutnya, digunakan hewan percobaan tikus (Raffus norvegicus L.).
IMPLIKASI PERSEPSI HAK KEPEMILIKAN TERHADAP TINDAKAN MASYARAKAT DALAM PENGELOLAAN SUMBERDAYA PERIKANAN LAUT (STUDI KASUS DI DESATELUK, KABUPATEN PANDEGLANG, PROPINSI BANTEN)
Authors: Priyatna Fatriyandi Nur , Hartono Tjahjo Tri , Nasution Zahri
Published: March 2017

Penelitian ini bertujuan untuk mengkaji persepsi hak kepemilikan, dasar pengambilan keputusan dalam bertindak dan implikasinya terhadap model pengelolaan sumberdaya perikanan (SDP). Metode penelilian yang dipilih adalah metode triangulasi, yaitu gabungan dari studi kasus, observasi dan studi pustiaka. Penelitian dilakukan di Desa Teluk, Kabupaten Pandeglang, Propinsi Banten selama Bulan April-Juni 2004.
ANALISIS PRIORITASI PEMILIHAN KOMODITAS DAN LOKASI SENTRA PENGEMBANGAN INDUSTRI PENGOLAHAN PERIKANAN DI KAWASAN TIMUR INDONESIA
Authors: Tajerin Tajerin , Manadiyanto Manadiyanto , Pranowo Sapto Adi
Published: March 2017

Penelitian ini bertujuan untuk mengkaji prioritasi pemilihan komoditas dan lokasi sentra pengembangan industri pengolahan perikanan di Kawasan Timur Indonesia dengan pendekatanmetode perbandingan eksponensial. Penelitian dilakukan sejak bulan Januari hingga Desember 2003. Data diperoleh dari hasil wawancara dengan responden yang dianggap ahli.
The Modern Induced Matter Approach of General Relativity for Quantum Mechanics
Authors: Thuan Vo Van , Thoa Nguyen Thi Kim
Published: March 2017

Wesson and his co-workers developed so-called space-time-matter theory (5D-STM) as a generalization of Kaluza-Klein theory, where the extra-dimension in the 5D space-time is no more compacted, but keeping extended in a macroscopic scale to describe the properties of matter in 4D physics. In a trend of 5D-STM approach (or the induced-matter theory), following a bi-cylindrical model of geometrical dynamics, a recent study has shown that the higher 6D-dimensional gravitational equation leads to bi-geodesic description in an extended timespace symmetry which ﬁts Hubble expansion in a ”microscopic” cosmological model. As a duality, the geodesic solution is mathematically equivalent to the basic Klein-Gordon-Fock equations of free massive elementary particles. The 4D-embedded dual solutions of the higher dimensional gravitational equation could shed light on origin of physical reality in quantum mechanics, which is to compare with the achievements of the 5D-STM theory.
Transient Absorption Phenomena in Synthetic HPHT and CVD Diamonds for a Fast Timing in Nuclear Instrumentation
Authors: Buganov O. , Tikhomirov S. , Barbarchik E. , Korjik M. , Fedorov A. , Mechinsky V. , Tamulaitis G.
Published: March 2017

In this study, we investigate  transient phenomena in synthetic diamonds  obtained by High Pressure High Temperature and Chemical Vapor Deposition methods. Study was aimed at searching for inorganic crystalline media combining ionizing radiation detecting properties and non-linear absorption of ultra-short laser pulses. The nonlinear pump-and-probe optical absorption technique with of 140 fs laser pulses was used to study the effects.
Sintonización De Un Controlador PID En Un PLC Haciendo Uso De Inteligencia De Enjambres/Auto-tuning of a PID controller implemented in a PLC using swarm intelligence
Authors: López Sotelo Jesuús Alfonso , Duque Marín Arturo , Navas Andrés Felipe
Published: March 2017

En este trabajo se muestra la implementación en un PLC Allen Bradley de un algoritmo de inteligencia de enjambres cuya función es determinar el modelo matemático de un sistema o proceso; con el modelo del sistema encontrado, se calculan los parámetros de un controlador PID que garantizan un comportamiento deseado del sistema. El algoritmo usado para encontrar el modelo matemático es una técnica de computación evolutiva conocida como optimización por enjambre de partículas.Para probar el funcionamiento del algoritmo implementado en el PLC, se realizaron simulaciones de sistemas dinámicos en el software Matlab, desde este software se estableció comunicación con el PLC. El PLC recibe la salida del sistema y, con esta información, encuentra un modelo del mismo, con el modelo encontrado sintoniza un controlador PID para, de esta manera, calcular la acción de control que enviará al sistema simulado en Matlab. Como estándar de comunicación industrial entre el PLC y  Matlab  se usó el OPC (OLE for Process Control). Lo anterior permitió vislumbrar la  posibilidad de implementar el algoritmo propuesto en una ambiente industrial.
A Solution for Problems in the Organization, Storage and Processing of Large Data Banks of Physiological Variables
Authors: Palominos Fredi , Díaz Hernan , Córdova Felisa , Cañete Lucio , Durán Claudia
Published: March 2017

The proliferation and popularization of new instruments for measuring different types of electrophysiological variables have generated the need to store huge volumes of information, corresponding to the records obtained by applying this instruments on experimental subjects. Together with this must be added the data derived from the analysis and purification processes. Moreover, several stages involved in the processing of data is associated with one or more specific methods related to the area of research and to the treatment at which the base information (RAW) is subjected. As a result of this and with the passage of time, various problems occur, which are the most obvious consequence of that data and metadata derived from the treatment processes and analysis and can end up accumulating and requiring more storage space than the base data. In addition, the enormous amount of information, as it increases over time, can lead to the loss of the link between the processed data, the methods of treatment used, and the analysis performed so that eventually all becomes simply a huge repository of biometric data, devoid of meaning and sense. This paper presents an approach founded on a data model that can adequately handle different types of chronologies of physiological and emotional information, ensuring confidentiality of information according to the experimental protocols and relevant ethical requirements, linking the information with the methods of treatment used and the technical and scientific documents derived from the analysis. Consequently, the need to generate specific data model is justified by the fact that the tools currently associated with the storage of large volumes of information are not able to take care of the semantic elements that make up the metadata and information relating to the analysis of base records of physiological information. This work is an extension of our paper [25].
Using Aesthetic Response - A Poetic Inquiry to Expand Knowing, Part I: The Rx6-Method
Authors: Gerge Anna , Wärja Margareta , Nygaard Pedersen Inge
Published: March 2017

A step-wise research procedure of arts-based research (ABR) called the Rx6 method is presented. This ABR method is informed by expressive arts therapy, heuristic inquiry, attachment theory, and contemporary affective neuroscience, and is aimed at deepening the understanding of embodied felt sense. The Rx6 approach is based in aesthetics and a pragmatic pre-understanding inspired from an interpretive and a constructivist tradition. The method is a heuristic endeavour where art is applied towards the creation of meaning. For the purpose of exemplifying this method, artwork, produced within the context of a randomized control trial as part of a mixed methods study involving women treated for gynaecological cancer, was used. Response art consisting of short written aesthetic responses to pictorial artifacts was applied in a structured manner. The data provided a rich artistic material in which to dialogue with artifacts in search of a condensed response statement. The Rx6 method involves six steps: to relate, resonate, respond, reflect and react to results. Engaging in ABR can offer clinicians and researchers a deepened, expanded, and embodied understanding of the studied phenomena. The complexity of sharing implicit processes and tacit knowledge, its caveats and gains, along with theoretical perspectives of such undertakings, are presented and discussed.