bluuebunny/crossref_metadata_2025 huggingface dataset:
Clumped isotope thermometry in deep time palaeoceanography
Authors:   , Kocken Ilja Japhir
Published: December 2022

This thesis explores clumped isotope thermometry in deep time palaeoceanography. We have improved the clumped isotope method, and applied it to gain new absolute temperature estimates for records from the surface oceans across critical climate transitions, as well as insights into deep ocean temperature evolution throughout the late Cenozoic. These new results will provide tuning targets for climate models. If the climate models can accurately simulate palaeoclimate, this increases our confidence in predictions for future climate change.

With respect to the average Earth System Sensitivity (ESS) of recent clumped isotope studies of ~6.3°C per doubling of CO2, our results from Walvis Ridge Site 1264 and previous results from the Indian Ocean reveal even higher ESS for the time interval encompassing the onset of the MCO until the Pliocene warm period. This may imply that the water masses in which this site bathed were extremely sensitive to greenhouse warming. Below atmospheric CO2 concentrations of 700 ppm, it appears that the sensitivity may have been higher, potentially suggesting a climate state dependence (as explained in von der Heydt et al., 2016). If we look at Pliocene modelling results, an ESS of 6.2°C was suggested previously (Haywood et al., 2020). Though the uncertainty of our Pliocene data is large, the average suggests a larger sensitivity. A previous latest Miocene estimate of ESS of 9.3±3.8°C seems compatible with our estimates (Brown et al., 2022). High-CO2 world clumped estimates corroborate findings from other studies. If we fit a line separately through the data with atmospheric CO2 concentrations >700 ppm, the slope is similar to the younger interval, albeit with a different intercept.

In the most recent IPCC report, palaeoclimate estimates of ECS were used to weigh the model ensemble mean in AR-6, where models with high ECS were given less weight. Our new insights from clumped isotopes may indicate that this weighing should be reconsidered. Furthermore, scaling sparse estimates of sea surface temperature from particular sites to a global average is hard, and analysing deep ocean temperatures that scale to changes in GMST may be a way forward. As our palaeoclimate studies are used more and more to anchor climate models, we must become ever more diligent in understanding all the factors that drive our proxy systems. Proper treatment of both measurement and systematic uncertainties will be paramount in the next decades of palaeoceanography research.
Epigenetics, Assisted Reproduction, and Intracytoplasmic Sperm Injection: A Review of the Current Data
Authors: Hutanu Delia , Bechir Melihan , Popescu Raluca
Published: December 2022

Since the birth of the first in vitro fertilisation baby in 1978, >5 million babies have been born worldwide using assisted reproductive technologies (ART). ART were initially considered safe, but, in recent years, concerns regarding the association between these procedures and the increasing incidence of imprinting diseases have developed. There are numerous steps involved in ART and there are many variables that must be considered; even parental infertility may play an important role in offspring epigenetic modifications. This review presents available data from the literature regarding the incidence of these epigenetic modifications after ART, with a primary focus on oocyte insemination methodology. The authors conclude that ART, especially intracytoplasmic sperm injection, may induce epigenetic changes that can be transmitted to the offspring, but additional data are necessary to evaluate the factors involved and to determine the safety of each ART step.
Description and Outcomes of Current Clinical Techniques for Sperm Cryopreservation
Authors: Palomar Rios Andrea , Molina Botella Inmaculada
Published: December 2022

Nowadays, sperm cryopreservation is strongly recommended in cases of malignancy. Moreover, the use of frozen testicular sperm in azoospermic patients prevents the need for repeated sperm retrieval and optimises scheduling between oocyte and sperm obtainment. Even though cryopreservation of human spermatozoa for assisted reproductive purposes is a widely implemented practice, none of the established freezing and vitrification techniques offer optimal cryosurvival results due to the dramatic impact of cryodamage on sperm cells. This comprehensive review describes the most commonly used sperm cryopreservation techniques in order to establish which of them minimise sperm cryodamage and offer better survival rates. Presently, it is not sufficiently demonstrated that sperm vitrification improves survival significantly more than freezing methods. Slow freezing offers the best survival results when compared to other freezing protocols, and owing to its technical advantages, can be considered as one of the preferred protocols to be easily implemented in assisted reproduction laboratories. Moreover, several studies have suggested that sperm preparation prior to cryopreservation can improve thawed sample quality. However, other authors have demonstrated that freezing the fresh sample and performing semen preparation after thawing gives better results in regard to total motile sperm count and motility. Regarding clinical results, it is well established that similar or even better reproductive outcomes are achieved using frozen testicular sperm in cases of azoospermia or anejaculation. Moreover, the use of frozen semen in cancer patients can help to achieve good fertilisation and pregnancy rates. Finally, the use of frozen sperm is not at all associated with worse post-natal development.
Fertility Preservation in Women with Endometriosis: It is About Time We Talk About it!
Authors: Mendonça Carneiro Márcia , Lunardi Rocha Ana Luiza , de Ávila Ivete , França Ferreira Marcia Cristina
Published: December 2022

Endometriosis is a common benign disease that affects young women and carries a significant risk to the reproductive organs. Studies have shown that endometriosis is associated with diminished ovarian reserve and worse prognosis in assisted reproductive technology treatments. Surgical treatment aims to remove the disease while maintaining reproductive potential with minimal damage to the reproductive organs. The authors reviewed the published literature regarding fertility preservation in endometriosis, focussing on patient selection criteria, available treatment options, and follow-up. The goal of this study was to find evidence to answer the following clinical questions: how should women of reproductive age with endometriosis be managed, and what fertility-sparing options are available? Cryopreservation of embryos and mature oocytes are established techniques for preserving fertility in women during the reproductive period. Fertility preservation is a key consideration in the care of young girls and women with endometriosis, mainly those with ovarian endometriomas and advanced disease. Although no cohort studies have been published on the subject to date, adequate information detailing disease progression, treatment options, and the risks involved should be made available for these women. Available fertility preservation strategies include embryo and oocyte crypreservation, and women should be counselled individually on the risks, benefits, and costs involved with these options. In this scenario, management by a multidisciplinary endometriosis team is a fundamental step for producing successful results.
TALİHLİLER ZÜMRESİNDEN BİR TİP: NÂDÂN
Authors: ÖZKAN BAHAR Bahanur
Published: December 2022

Divan şiiri geleneği tipler açısından zengin bir görünüm arz etmektedir. Âşık, maşuk, rakip başta olmak üzere rind, zâhid, hâce, vâiz, sûfî, müddei, imam, nâsih gibi klişe denilebilecek birçok tipe sahiptir. Şairin kendisini gerçek, samimi bir âşık, rind-meşrep ve ârif, olgun birisi olarak tanımladığı gelenekte başta rakip olmak üzere pek çok tiple mücadele halinde olduğu görülür. Bunlardan birisi de nâdândır. Cahil anlamına gelen nâdân sadece ilim bilmeyen değil aslında aşkı, dünyayı, ahireti ya da yaratanı bilmeyen birisidir. Hal böyleyken kendisinde başkalarını tenkit etme hakkı gören ve sık sık eleştiren; sevgilinin tüm cahilliğine rağmen ilgisine, iltifatına muhatap olabilen birisidir. Divan şiirinde pek çok manzumede, nasihat ve ikazlarda nâdânın yer aldığı görülür. Kendisi ile çok vakit geçirilmemesi, dostluk edilmemesi ya da tartışmaya girilmemesi gereken nâdân tüm kötü vasıflarına rağmen oldukça şanslıdır. Âşığın her işini bozan felek nâdânın tüm işlerini dizmekte, yoluna koymaktadır. Feleğin desteğini ardına alan nâdân da sevgili başta olmak üzere pek çok dünya nimetinin tadını çıkarmaktadır. Kötü tiplerden birisi olan nâdân aynı zamanda diğer tiplerin taşıdığı bir özelliktir. Yani rakip, zâhid ya da herhangi birisinin sıfatı olarak da kullanılmaktadır. Çalışmada her iki kullanımın da örnekleri bulunmaktadır.
ORTA ÇAĞ AVRUPA HARİTALARINDA EZOTERİK SEMBOLİZM
Authors: TANRIKULU Murat
Published: December 2022

Orta Çağın ne zaman başladığı ve bittiği, bir çağı kapatıp yeni bir çağı başlatacak önemdeki bir olay üzerinde ortak bir karara ulaşılamaması nedeniyle Batı’da ve Doğu’da tartışmalıdır. Orta Çağın başlangıcını Kavimler Göçü (375) kabul edenler bulunduğu gibi, Roma İmparatorluğu’nun ikiye ayrılması (395) ya da Batı Roma’nın yıkılışı (476) olarak kabul edenler de vardır. Hangisi kabul edilirse edilsin bu çağ Avrupa için karanlık bir çağdır. Bunun temel nedeni, III. yüzyıldan Orta Çağın sonuna kadar Roma-Katolik Kilisesi'nin dogmatik uygulamalarıdır. Bu dönemde dini mistisizm, İncil ve kilise merkezli yaklaşım yaşamın her alanına baskın bir biçimde egemen oldu. Roma Katolik kilisesine bağlı din adamları, olay ve olgulara bu bakış açısının dışında bir bakışı kabul etmediler. Böyle bir ortamda dünya imajı ve çizilen haritalar da bu bakış açısına uygun olarak çizilmek zorundaydı. Orta Çağ Avrupa haritalarında ökümeni tasvir etmek için ya antik dönem iklim tasnifinden kalma ya dinsel ya da seyyahların söylencelerine uygun olarak abartılı piktogramlar eklendi. Bu piktogramların, bazıları çizenin ve çizdirenin kültürel arka planı ve bakış açısıyla açık, gizli, dini ya da uhrevi ezoterik kodlamalar içeriyordu. Çalışma, dile getirilen haritalardaki ezoterik sırların neler olduğu, sonraki yüzyıllarda nasıl anlaşıldığı ve hangi sonuçlara yol açtığı üzerinde kurgulanmıştır. Çalışmada yöntem olarak doküman analizinden ve hermeneutikten yararlanılmıştır.
ÜNİVERSİTE ÖĞRENCİLERİNİN AKILLI TELEFON KULLANIMI VE YENİ MEDYA DENEYİMLERİ: İZMİR DEMOKRASİ ÜNİVERSİTESİ ÖRNEĞİ
Authors: ÇAĞIRKAN Barış
Published: December 2022

Toplumsal aktörlerin hem benlikleri hem de toplum/topluluk ile ilintili algıları biyolojik doğum ile başlayan sosyalizasyon süreçleri çerçevesinde belirlenmektedir. Değişen ve gelişen kitle iletişim teknolojileri toplumsal aktörlerin sosyalizasyon algısını değiştirmiş ve yeni teknolojiler sayesinde daha geniş bir sosyalizasyon ağının yaratmıştır. Günümüzde gelişen internet altyapısı, akıllı telefonlar ve yeni medya araçları toplumsal aktörlerin benlik, kimlik, geleneksellik vb. gibi algılarını değiştirmiştir. Özellikle Z Kuşağı olarak nitelendirilen ve bu yeni teknolojik araçlarının içine doğmuş olan genç yetişkinlerin akıllı telefon ve yeni medya araçları ile olan ilişkisi önceki kuşaklardan farklılık göstermektedir. Bu bağlamda çalışma kapsamında İzmir Demokrasi Üniversitesi’nde eğitim gören 18 katılımcı ile nitel araştırma yöntemleri kullanılarak görüşme yapılmıştır. Elde edilen veriler içerik analiz yöntemi ile analiz edilmiştir. Analiz sonunda oluşturulan beş tema üzerinden (sosyal medya, akıllı telefon ve ekran bağımlılığı, kimlik ve benlik algısı, geleneksellik ve yeni sosyal, Z Kuşağı) genç yetişkinlerin akıllı telefon ve yeni medya deneyimleri incelenmiştir. Sosyal medya genç yetişkinlerin karar alma süreçleri, benlik sunumu ve kimlik algısı, gerçeklik algısını belirleyen en önemli faktördür. Akıllı telefonların içine doğan genç yetişkinler için akıllı telefonlar önceki kuşaklara kıyasla farklı bir anlama sahiptir. Önceki kuşaklar için lüks tüketim olarak görülen akıllı telefonlar sahip olduğu yaygın kullanım alanı ile genç yetişkinler için ihtiyaç haline gelmiştir.
NASREDDİN HOCA ENSTİTÜSÜ’NÜN KURULMASI TEKLİFİ ÜZERİNE BİR DEĞERLENDİRME
Authors: BAYRAKTAR Zulfikar
Published: December 2022

Türkiye, birçok farklı kültürle zenginleşmiş bir medeniyetin mirasçısı konumunda bir ülkedir. Atalarımız insanlık tarihine mimariden görsel sanatlara, edebiyattan musikiye kadar birçok alanda değerli eserler armağan etmişlerdir. Somut olmayan kültürel mirasımızın önemli bir parçası olan Nasreddin Hoca ve fıkraları sadece Türk Dünyasının değil, bunun yanı sıra diğer coğrafyalarda da hayatiyet gösterme kabiliyetine sahip önemli bir değerdir. Nasreddin Hoca, öncelikle Türk insanının bilinçaltının sözcüsü olmuş, sonrasında ise farklı kültürlere mensup toplumlarla entegre olarak Türk kültürünün evrensel yüzü haline gelmiştir. Nasreddin Hoca fıkralarında temelde ve özde insana ait tüm unsur ve durumlar hoşgörü çerçevesinde tartışılır ve çözüme bağlanır. Bu fıkralarda insanlar ayrıştırılmaz, ötekileştirilmez, din, dil, cinsiyet, ırk ve mezhep ayrımına tabi tutulmazlar. Aksine, insan olmanın evrensel normları bu anlatılarda yüceltilir ve tavsiye edilir. Nasreddin hoca fıkralarında ortaya konulan birlikte ve barış içerisinde yaşama kültürü, günümüz dünyasında insanlık adına çok önemli bir reçete olarak karşımızda durmaktadır. Nasreddin Hoca fıkralarının tüm insanlık adına verdiği mesajlar başta sosyal, kültürel, sanatsal, diplomatik ve siyasi bağlamda daha fazla yol gösterici bir potansiyeli kendi içerisinde barındırmaktadır. Bu yüzdendir ki çalışmamızda da teklif olunacağı üzere Nasreddin Hoca Enstitüsü’nün kurulması ve bu enstitü bünyesinde Nasreddin Hocanın hayatını, fıkralarını, fıkralarının yayılma sahalarını, Türk ve dünya edebiyatındaki yerini, özgünlüğünü ve değerini incelemek ve araştırmak; bahsi geçen amaçlar doğrultusunda çalışmalarda bulunmak, bilimsel, sosyal ve kültürel etkinlikler yapmak ve projeler gerçekleştirmek, basılı ve dijital yayımlar yapmak mümkün olacaktır. Ayrıca Nasreddin Hoca ile ilgili ulusal ve uluslararası yayınların toplandığı ihtisas kütüphanesi oluşturmak ve Nasreddin Hoca düşüncesinin Türk ve uluslararası toplumlarda tanınırlığını ve bilinirliğini arttırmaya yönelik çalışmalar yapmak bu enstitünün en önemli amaçlarından biri olarak hedeflenmektedir. Kurulması planlanan Nasreddin Hoca Enstitüsü ile ülkemizi, dilimizi, kültürel mirasımızı ve sanatımızı tanıtmak, Türkiye’nin diğer ülkelerle olan dostluğunu ve kültürel alışverişini sağlamak imkânı daha da güçlenecektir. İmajların endüstriye ve kültür diplomasisinin önemli bir enstrümanına dönüştürüldüğü günümüz dünyasında Nasreddin Hoca Enstitüsü’nün kurulması bu alandaki önemli bir boşluğu da dolduracaktır. Böylelikle, Türkiye’nin her alanda nitelikli temsilini sağlamak ve bu doğrultuda ‘Türkiye markasını güçlendirmek’ mümkün hale gelecektir.
BAKIŞIN FENOMENOLOJİSİ: PASTORAL SENFONİ’DE KÖRLÜK
Authors: KARACA Şahika
Published: December 2022

Bakış konusu öznenin kuruluşunu açıklamada büyük bir öneme sahiptir. Bakış, Ötekinin üzerinden gerçekleşir ve Öteki arzu alanının kuruluşu için gereklidir. Dolayısıyla varoluş alanı arzu yani yasak etrafında kurulduğu için bakışın önemi daha da iyi anlaşılmaktadır. Pastoral Senfoni’de de körlük ve bakış ekseninde eros ve thanatosun diyalektiği kurulmuştur. Romanda Gertrude’un günahla ilk karşılaşması gözleri açıldıktan sonradır. İlk kez Papaz’ın karısının gözlerinde acı hakikati gördükten sonra duyduğu suçluluk hissiyle intihar eder. Gözleri görmeden önce yasağın bilgisine sahip olmayan Gertrude gözleri açıldıktan sonra yasakla karşılaşır ve mutluluk hâli sona erer. Dolayısıyla bakış günah ve yasakla birlikte romanda acının ortaya çıkmasına neden olur.

Pastoral Senfoni’deki körlük ve körlük dolayımıyla üzerinde durulan bakış konusuyla ilk günah mitinden itibaren karşılaşılmaktadır. İlk günahla birlikte varoluş alanında Öteki ortaya çıkar. Böylece Öteki üzerinden bakış gerçekleşir. Sofokles’in Kral Oedipus oyununda da hakikatle karşılaşan Oidipus gözlerini kör eder. Nitekim Pastoral Senfoni’de de Rahip’le oğlu Jacques arasında geçen diyaloglarda adı sık sık geçen Aziz Pavlus da hakikatle karşılaştığında gözleri kör olur. Dolayısıyla körleşme gerçekten bakışı çevirme etrafında açıklanabilir. Oidipus’un annesi Jacoste ve Gertrude’un ise gerçeğe bakışları beden bütünlüklerine son vermeyle/intiharla sonuçlanır. Bu durum eril ve dişil olanın gerçeğe karşı aldıkları tavırların farklılığından kaynaklanmaktadır. Pastoral Senfoni’de Gertrude körlük ve bakış ekseninde eros ve thanotos çatışmasının şiddetiyle Öteki’nin bakışından bedenini çekmiştir.
THE ROLE OF HYPNOSIS IN A PATIENT WHO DOES NOT WANT TO GIVE BLOOD SAMPLES IN THE EMERGENCY
Authors: Turtay Muhammet Gökhan , Güzel Sinan , Güzel Okyanus Rengin
Published: December 2022

Introduction: We aimed to present the patient who applied to the emergency department, who did not want to be tested due to fear of giving blood sample, but was discharged after blood sample was taken comfortably with hypnosis application.
Case Report: A forty six-year-old female patient was admitted to the emergency department with complaints of headache and fatigue. It was learned that the patient avoided going to the hospital because of the fear of giving blood samples for years. Blood tests were requested from the patient, but the patient stated that she did not want to give blood sample. The patient accepted our offer to take blood under hypnosis and stated that he would try to give blood with this method. Thereupon, the patient was taken to a suitable environment and stretcher in the emergency room. During this hypnosis session, which lasts about 15 minutes, the patient; she gave samples for blood tests very comfortably and happily. The patient, who stated her happiness after the procedure, continued her next procedures in a relaxed way.
Conclusion: Hypnosis application is a method that can be used by emergency doctors according to the needs of patients who are fear of giving blood samples.
References:
1. Colón Y, Avnet MS. Medical hypnotherapy for pain management. J Pain Palliat Care Pharmacother 2014;28(2):174-6.
2. Hammond DC. Review of the efficacy of clinical hypnosis with headaches and migraines. Int J Clin Exp Hypn 2007;55(2):207-19.
3. Iserson KV. An hypnotic suggestion: review of hypnosis for clinical emergency care. J Emerg Med 2014;46(4):588-96.
4. Willemsen R. Hypnosis technics used to diminish anxiety and fear: review of the literatüre. Rev Belge Med Dent (1984) 2003;58(2):99-104.
Sustainability of Karacaören-I Dam Lake Rainbow Trout Cage Farming (Türkiye) in Terms of Cultural Energy and Carbon Footprint Expended on Compound Diet and Transportation
Authors: DİKEN Gürkan
Published: December 2022

The purpose of this study was to assess the consumed compound diet and juvenile fish, harvested fish, and compound diet transport of Karacaören Dam Lake-I rainbow trout cage farming (KRTC) in terms of cultural energy (CE) and carbon footprint (CF) expended sustainability. Data was collected through face-to-face interviews with the farmers. Cultural energy and carbon footprint were calculated with the data obtained from the literature. The lowest and highest FCRs in KRTC were 0.91 and 1.18, the closest and farthest distances related to transportation were 387 and 427 km for aquafeed factories, 7 and 650 km for hatcheries, and 67 and 450 km for processing factories. Cultural energy and carbon footprint expended on consumed compound diet (CECD-Gcal and Mcal kg-1, and CFCD-tonne CO2e and kg CO2e kg-1) and cultural energy and carbon footprint expended on transportation analyzes (CET-Gcal and Mcal kg-1, and CFT-tonne CO2e and kg CO2e kg-1) were performed according to the literature of 20-40 g fish stocked in the beginning of November 2020 and 270-500 g harvested until early June 2021 in the basin. In the access of sustainability, the CE (Mcal kg-1) and CF (CO2e kg-1) expended values in kg of the harvested fish were given. The average values of CE expended of 5 different aquafeed groups used in the basin were 3.65, 3.58, 3.41, 3.25, and 3.55 Mcal kg-1, respectively and the average values of CF expended were 1.05, 1.03, 1.14, 1.40, and 1.10 kg CO2e kg-1, respectively. The average share of CE and CF in the compound diet was 86.59% and 86.61%, respectively. The KRTC sustainability criterion for compound diet and transportation values was 2.9260 CE:CF. It is recommended to develop a sustainability index of aquaculture systems and species-specific CE and CF expended values.
Antimicrobial Activity of Eucalyptus (Eucalyptus camaldulensis) Essential Oil Against Fish Pathogen Bacterium, Aeromonas caviae
Authors: BEKTAŞ Serdar , ÖZDAL Murat
Published: December 2022

The intensive use of antibiotics in aquaculture has resulted in increased resistance among fish pathogens, and this situation has led researchers to investigate the antibacterial properties of natural resources. The present study focused on an essential oil isolated from the leaves of Eucalyptus camaldulensis as a potential antibacterial that could be used against Aeromonas caviae. Eighteen compounds were identified in the essential oil, representing 86.68 % of the total oil. The components were found to be p-cymene (20.09%), β-phellandrene (18.61%), α-phellandrene (7.50%), α-terpineol (6.02%), terpinen-4-ol (5.50%), Crypton (5.36%), spathulenol (4.26%), linalool (3.56%), 1,8-cineole (2.77%), farnesol (2.31%), Cumin aldehyde (2.13%), limonen (2.12%), α-thujene (1.94%), fellendral (1.13%), γ-terpinene (1.10%), sabinene (0.97%), α-pinene (0.68%) and α-terpinen (0.63%). The antibacterial efficiency of essential oils against Aeromonas caviae was determined using Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values, ranging from 200 µg/ml to 400 µg/ml respectively. Our findings revealed the potential of essential oils isolated from Eucalyptus (Eucalyptus camaldulensis) as a natural antibacterial agent that could efficiently contribute to the control of Aeromonas caviae infection in fish.
Modern priorities in the field of combating money laundering and terrorist financing
Authors:   SESE “The Academy of Financial Management”, IEFYMENKO Tetiana , DMYTRENKO Tetiana ,   SESE “The Academy of Financial Management”
Published: December 2022

Introduction. The introduction of international sanctions as a tool to counter military aggression by the Russian Federation in Ukraine affected the priorities of anti-legalization activities at the global level. Recently, the use of the latest technologies has attracted the attention of FATF and other international organizations. With the beginning of the unprovoked aggression against Ukraine, operative and effective assistance to the country was organized through the collection of funds by charitable crypto funds. Problem.The latest technologies have ensured the active citizenship of people from different countries of the world. On the other hand, such activity, related to the support of the Ukrainian people, also activated the criminal world, whose transactions were passed off as charitable activities. Goal. Provide a brief summary outlining national priorities as well as some practical definitions and financial red flags of financial and crypto market activity. Methods. General and special methods are used: analysis, synthesis, grouping, description, comparison, theoretical generalization, and abstract-logical. Results. Attention is focused on the urgent need for further implementation of international standards in the field of combating the use of proceeds of crime and the financing of terrorism in Ukraine, which, with Ukraine's acquisition of the status of a candidate for membership of the European Union, has become a component of the necessary steps for membership in the European community. Conclusions. The final decision on the issue of the immediate introduction of regulation of the virtual assets market, registration of its participants, interaction with foreign regulatory and law enforcement agencies of this economic sector will contribute to more effective implementation of sanctions to stop Russian aggression in Ukraine, restoration and modernization of the state, and Ukraine's integration into the European Union.
Internal development factors of state financial monitoring in Ukraine
Authors:   SHEE “Kyiv National Economic University named after Vadym Hetman”, ABESINOVA Оlena
Published: December 2022

In the article, based on the results of the study of the main regulations for the development of financial monitoring, the internal factors of the state financial monitoring of Ukraine and their impact on the efficiency of the financial monitoring service are determined. It has been established that among the main areas of activity of the State Financial Monitoring Service, a significant area is the selection of personnel and the organization of work on the training and improvement of the qualifications of employees. Considerable attention is paid to the system of employee motivation, as one of the main factors in the development of the State Financial Monitoring System of Ukraine. The objective necessity of using not only material, but also moral stimulation of civil service workers in the motivation system is substantiated. The need to create an effective employee motivation system that would contribute to the effective development of the State Financial Monitoring Service was proven. When improving the institution's motivational strategy, it is suggested to take into account the principles of behavioral economics, which are based on the characteristics of irrational employee behavior and psychological features of human perception.
Human centering and ecologization of production as the main elements of ensuring the economic security of the enterprise
Authors:   National University of Food Technologies, TRETIAK Kateryna , GERASYMENKO Dariia ,   National University of Food Technologies
Published: December 2022

The article reveals the theoretical, methodological and practical aspects of ensuring the economic security of the enterprise, which affects the dynamics of the national economy in general. The purpose of the study is a scientific and practical assessment of the theoretical foundations of economic security of the enterprise. The methodological basis is general scientific methods, namely: logical generalization, dialectical, tabular, graphic, synthesis, induction, deduction. The information base was, in particular, scientific professional articles, materials of dissertation studies, Internet sources, etc. The approaches of modern economists, as well as the author's approach to this phenomenon, are presented. Factors affecting the economic security of the enterprise are shown. It is proposed to expand the principles of its provision by adding people-centeredness at the enterprise and greening of production. Adherence to these principles will make it possible to more clearly understand the process of sustainable development of the enterprise. They can be supplemented taking into account changes in the exogenous and endogenous policies of the enterprise, changing conditions, industry specifics and state policy. Practical examples of the necessity of greening the enterprise's production activity and people-centeredness are demonstrated. A structural and logical scheme for ensuring the economic security of the enterprise has been formed.
Pelatihan Teknik Pengecoran Aluminium Bagi Usaha Pengepul Barang Bekas Di Kecamatan Poasia Kota Kendari
Authors: Sudarsono Sudarsono , Aminur Aminur , Sudia Budiman , Endriatno Nanang , Barata La Ode Ahmad
Published: December 2022

Handling of used aluminum has been carried out by collectors, namely the compression process. The pressing process is less economical because it still produces cavities and the selling price is low. The purpose of this community service activity is to provide training on Aluminum smelting with casting techniques for two groups of independent collectors, Mandiri Berkah and Maju Jaya. The activity took place in the Mandiri Berkah collector area which was attended by Mandiri Berkah and Maju Jaya employees and the community around Poasia. The method of implementing the activity is a theoretical explanation of Aluminum and its processing method with casting techniques. Used aluminum cans are melted in a charcoal-fired crucible furnace. The used aluminum cans are put in the kowi which is placed in a hot furnace. After the cans are melted, they are poured into rectangular molds. The results of the service activities that resulted were the opening of knowledge insights related to used aluminum. Participants were able to recycle Aluminum by casting technique into ingot products.Keywords: Training, foundry, aluminum, collectors
Pectin-based bioinks for 3D models of neural tissue produced by a pH-controlled kinetics
Authors: Merli Marta , Sardelli Lorenzo , Baranzini Nicolò , Grimaldi Annalisa , Jacchetti Emanuela , Raimondi Manuela Teresa , Briatico-Vangosa Francesco , Petrini Paola , Tunesi Marta
Published: December 2022

Introduction: In the view of 3D-bioprinting with cell models representative of neural cells, we produced inks to mimic the basic viscoelastic properties of brain tissue. Moving from the concept that rheology provides useful information to predict ink printability, this study improves and expands the potential of the previously published 3D-reactive printing approach by introducing pH as a key parameter to be controlled, together with printing time.

Methods: The viscoelastic properties, printability, and microstructure of pectin gels crosslinked with CaCO3 were investigated and their composition was optimized (i.e., by including cell culture medium, HEPES buffer, and collagen). Different cell models representative of the major brain cell populations (i.e., neurons, astrocytes, microglial cells, and oligodendrocytes) were considered.

Results and Discussion: The outcomes of this study propose a highly controllable method to optimize the printability of internally crosslinked polysaccharides, without the need for additives or post-printing treatments. By introducing pH as a further parameter to be controlled, it is possible to have multiple (pH-dependent) crosslinking kinetics, without varying hydrogel composition. In addition, the results indicate that not only cells survive and proliferate following 3D-bioprinting, but they can also interact and reorganize hydrogel microstructure. Taken together, the results suggest that pectin-based hydrogels could be successfully applied for neural cell culture.
Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain
Authors: Zhang Jieyuan , Wang Cheng , Li Xueqian , Fu Shaoling , Gu Wenqi , Shi Zhongmin
Published: December 2022

Background: Because of the rising prevalence of anterior talofibular ligament (ATFL) damage, there is a considerable interest in developing innovative techniques to improve the biological healing response of ATFL. Platelet-rich plasma (PRP) includes several growth factors linked to a favorable healing response, however none of the studies involved both quality evaluation and clinical results to evaluate this treatment.

Purpose: To determine the clinical results of PRP injections into the ATFL in lateral ankle sprain (LAS) patients, as well as the quality of the ATFL based on radiographic outcomes.

Methods: Patients with clinically confirmed grade II LAS for the first time (n = 83) were examined. The clinical outcomes of three types of injection methods were evaluated: none, once within 48 h after the sprain, and once more 4 weeks later after first injection. PRP was injected into the tear site of the ATFL using ultrasound guidance, and all ankles were immobilized for 2 weeks. The American Orthopedic Foot and Ankle Score (AOFAS) ankle-hindfoot scale and the Visual Analogue Scale (VAS) were used to assess the results at 2, 6, 8, 24, and 48 weeks of follow-up. The signal/noise ratio (SNR) value of Magnetic Resonance Imaging (MRI)-based ATFL signal intensity can disclose ATFL quality. The ATFL SNR results were then assessed 8, 24 and 48 weeks following the first injection to compare ATFL quality.

Results: The PRP injection groups outperformed the control group in terms of clinical outcomes, and the two injections group outperformed other groups in terms of pain reduction and functional outcome at 8 weeks. The clinical results of all groups were comparable at 6 and 12 months follow-up. ATFL SNR findings improved significantly across all groups over time. At the same follow-up time, the PRP injection groups outperformed the control group, and the best SNR result showed in the two injections group at the final follow-up.

Conclusion: PRP injection helped relieve early symptoms of LAS, although all patients saw a similar development after 6 months. The two PRP injections group produced considerably better clinical results and quality of the ATFL in short-term follow-up.
MiRNAs from serum-derived extracellular vesicles as biomarkers for uveal melanoma progression
Authors: Wróblewska Joanna Patrycja , Lach Michał Stefan , Rucinski Marcin , Piotrowski Igor , Galus Lukasz , Suchorska Wiktoria Maria , Kreis Stephanie , Marszałek Andrzej
Published: December 2022

Uveal melanoma (UM) is a rare type of malignancy that originates from melanocytes in the choroid, iris and the eye’s ciliary body. Biomarkers for early detection and progression of UM, especially the molecular traits governing the development of metastasis, are still not available in clinical practice. One extensively studied components of liquid biopsies are extracellular vesicles. Due to their unique molecular cargo, they can contribute to early cancer development and at the same time carry markers for disease onset and progression. For characterisation of the miRNA profiles present in circulating serum-derived exosomes of patients with diagnosed primary and metastatic UM, we have analyzed the miRNA cargos using next-generation sequencing followed by RT-qPCR validation in a cohort of patients (control n = 20; primary n = 9; metastatic n = 11). Nine miRNAs differentiating these patient groups have been established. We show that hsa-miR-144-5p and hsa-miR-191-5p are the most promising biomarker candidates, allowing the categorization of patients into local and advanced UM. Additionally, the comparison of miRNA expression levels in exosomes derived from UM patients with those derived from healthy donors revealed that hsa-miR-191-5p, -223-3p, -483-5p, -203a has the potential to be used as an early marker for the presence of UM. This pilot study reveals that miRNAs extracted from circulating exosomes could be exploited as potential biomarkers in UM diagnosis and, more importantly, for indicating metastatic spread.
Heritability of the glycan clock of biological age
Authors: Mijakovac Anika , Frkatović Azra , Hanić Maja , Ivok Jelena , Martinić Kavur Marina , Pučić-Baković Maja , Spector Tim , Zoldoš Vlatka , Mangino Massimo , Lauc Gordan
Published: December 2022

Immunoglobulin G is posttranslationally modified by the addition of complex N-glycans affecting its function and mediating inflammation at multiple levels. IgG glycome composition changes with age and health in a predictive pattern, presumably due to inflammaging. As a result, a novel biological aging biomarker, glycan clock of age, was developed. Glycan clock of age is the first of biological aging clocks for which multiple studies showed a possibility of clock reversal even with simple lifestyle interventions. However, none of the previous studies determined to which extent the glycan clock can be turned, and how much is fixed by genetic predisposition. To determine the contribution of genetic and environmental factors to phenotypic variation of the glycan clock, we performed heritability analysis on two TwinsUK female cohorts. IgG glycans from monozygotic and dizygotic twin pairs were analyzed by UHPLC and glycan age was calculated using the glycan clock. In order to determine additive genetic, shared, and unique environmental contributions, a classical twin design was applied. Heritability of the glycan clock was calculated for participants of one cross-sectional and one longitudinal cohort with three time points to assess the reliability of measurements. Heritability estimate for the glycan clock was 39% on average, suggesting a moderate contribution of additive genetic factors (A) to glycan clock variation. Remarkably, heritability estimates remained approximately the same in all time points of the longitudinal study, even though IgG glycome composition changed substantially. Most environmental contributions came from shared environmental factors (C), with unique environmental factors (E) having a minor role. Interestingly, heritability estimates nearly doubled, to an average of 71%, when we included age as a covariant. This intervention also inflated the estimates of unique environmental factors contributing to glycan clock variation. A complex interplay between genetic and environmental factors defines alternative IgG glycosylation during aging and, consequently, dictates the glycan clock’s ticking. Apparently, environmental factors (including lifestyle choices) have a strong impact on the biological age measured with the glycan clock, which additionally clarifies why this aging clock is one of the most potent biomarkers of biological aging.
Recent progress in the design of photocatalytic H2O2 synthesis system
Authors: Wen Haobing , Huang Sen , Meng Xianguang , Xian Xiaole , Zhao Jingjing , Roy Vellaisamy A. L.
Published: December 2022

Photocatalytic synthesis of hydrogen peroxide under mild reaction conditions is a promising technology. This article will review the recent research progress in the design of photocatalytic H2O2 synthesis systems. A comprehensive discussion of the strategies that could solve two essential issues related to H2O2 synthesis. That is, how to improve the reaction kinetics of H2O2 formation via 2e− oxygen reduction reaction and inhibit the H2O2 decomposition through a variety of surface functionalization methods. The photocatalyst design and the reaction mechanism will be especially stressed in this work which will be concluded with an outlook to show the possible ways for synthesizing high-concentration H2O2 solution in the future.
An in-cluster Sfp-type phosphopantetheinyl transferase instead of the holo-ACP synthase activates the granaticin biosynthesis under natural physiological conditions
Authors: Deng Ming-Rong , Chik Sin Yu , Li Yan , Zhu Honghui
Published: December 2022

Bacterial aromatic polyketides are mainly biosynthesized by type II polyketide synthases (PKSs). The PKSs cannot be functional unless their acyl carrier proteins (ACPs) are phosphopantetheinylated by phosphopantetheinyl transferases (PPTases). Gra-ORF32 was identified as an in-cluster PPTase dedicated for granaticin biosynthesis in Streptomyces vietnamensis and the Arg- and Pro-rich N terminus was found to be crucial for catalytic activity. Overexpression of the encoding genes of the holo-ACP synthases of fatty acid synthases (FAS ACPSs) of both E. coli and S. vietnamensis could efficiently activate the production of granaticins in the Δgra-orf32 mutant, suggesting the ACP of granaticin (graACP) is an efficient substrate for FAS ACPSs. However, Gra-ORF32, the cognate PPTase of the graACP, could not compensate the conditional deficiency of ACPS in E. coli HT253, indicating that it has evolved to be functionally segregated from fatty acid biosynthesis. Nine out of eleven endogenous and all the tested exogenous non-cognate PPTases could activate the production of granaticins to varied extents when overexpressed in the Δgra-orf32 mutant, indicating that ACPs of type II PKSs could also be widely recognized as effective substrates by the Sfp-type PPTases. The exogenous PPTases of type II PKSs activated the production of granaticins with much higher efficiency, suggesting that the phylogenetically distant in-cluster PPTases of type II PKSs could share substrate preferences for the ACPs of type II PKSs. A significantly elevated production of granaticins was observed when the mutant Δgra-orf32 was cultivated on ISP2 plates, which was a consequence of crosstalk between the granaticin pathway and a kinamycin-like pathway as revealed by transcriptome analysis and pathway inactivations. Although the host FAS ACPS could efficiently activate the production of granaticins when overexpressed, only Gra-ORF32 activated the efficient production of granaticins under natural physiological conditions, indicating that the activity of the host FAS ACPS was strictly regulated, possibly by binding the FAS holo-ACP product with high affinity. Our findings would contribute to a more comprehensive understanding of how the ACPs of type II PKSs are activated and facilitate the future functional reconstitutions of type II PKSs in E. coli.
Preventing and debunking earthquake misinformation: Insights into EMSC's practices
Authors: Fallou Laure , Corradini Marina , Bossu Rémy , Cheny Jean-Marc
Published: December 2022

Misinformation spreads fast in times of crises, corroding public trust and causing further harm to already vulnerable communities. In earthquake seismology, the most common misinformation and misleading popular beliefs generally relate to earthquake prediction, earthquake genesis, and potential causal relations between climate, weather and earthquake occurrence. As a public earthquake information and dissemination center, the Euro-Mediterranean Seismological Center (EMSC) has been confronted many times with this issue over the years. In this paper we describe several types of earthquake misinformation that the EMSC had to deal with during the 2018 Mayotte earthquake crisis and the 2021 La Palma seismic swarm. We present frequent misinformation topics such as earthquake predictions seen on our communication channels. Finally, we expose how, based on desk studies and users' surveys, the EMSC has progressively improved its communication strategy and tools to fight earthquake misinformation and restore trust in science. In this paper we elaborate on the observed temporality patterns for earthquake misinformation and the implications this may have to limit the magnitude of the phenomenon. We also discuss the importance of social, psychological and cultural factors in the appearance and therefore in the fight against misinformation. Finally, we emphasize the need to constantly adapt to new platforms, new beliefs, and advances in science to stay relevant and not allow misinformation to take hold.
Changes in teaching from the perspective of novice and retired teachers: Present and past in review
Authors: García-Hernández María Luisa , Bernárdez-Gómez Abraham , Porto-Currás Mónica , Torres-Soto Ana
Published: December 2022

Background

This study aimed to understand the perceptions that Spanish teachers of different educational levels have about the functions attributed to them, the overload of administrative tasks that they face daily, and the external consideration that their professional profile has raised. A generational perspective was adopted in this study, taking into consideration different educational stages: Early Childhood, Primary, and Secondary Education.

Methods

This descriptive study was developed using a qualitative methodology. The data were extracted through semi-structured interviews with 60 Spanish teachers from public schools. The information was analyzed with the qualitative data analysis tool ATLAS.ti, version 22.

Results

The results extracted from this study expose the overload of administrative work that teachers face daily, preventing them from developing pedagogical tasks that can improve their practice. In addition, the results highlight that a series of prejudices and negative external considerations toward the figure of the teacher are developing in the society.

Conclusion

It can be concluded that older and more experienced teachers in educational centers place more emphasis on the work overload that they have assumed over the years in their work. However, novice teachers do not show as much concern about this work overload. Additionally, teachers state that the society has a negative regard for their work.
Roles of extracellular vesicles associated non-coding RNAs in Diabetes Mellitus
Authors: Gauthier Benoit R. , Cobo-Vuilleumier Nadia , López-Noriega Livia
Published: December 2022

Extracellular vesicles (EVs), especially exosomes (50 to 150 nm), have been shown to play important roles in a wide range of physiological and pathological processes, including metabolic diseases such as Diabetes Mellitus (DM). In the last decade, several studies have demonstrated how EVs are involved in cell-to-cell communication. EVs are enriched in proteins, mRNAs and non-coding RNAs (miRNAs, long non-coding RNAs and circRNAS, among others) which are transferred to recipient cells and may have a profound impact in either their survival or functionality. Several studies have pointed out the contribution of exosomal miRNAs, such as miR-l42-3p and miR-26, in the development of Type 1 and Type 2 DM (T1DM and T2DM), respectively. In addition, some miRNA families such as miR-let7 and miR-29 found in exosomes have been associated with both types of diabetes, suggesting that they share common etiological features. The knowledge about the role of exosomal long non-coding RNAs in this group of diseases is more immature, but the exosomal lncRNA MALAT1 has been found to be elevated in the plasma of individuals with T2DM, while more than 169 lncRNAs were reported to be differentially expressed between healthy donors and people with T1DM. Here, we review the current knowledge about exosomal non-coding RNAs in DM and discuss their potential as novel biomarkers and possible therapeutic targets.
Prolactin in relation to gestational diabetes and metabolic risk in pregnancy and postpartum: A systematic review and meta-analysis
Authors: Rassie Kate , Giri Rinky , Joham Anju E. , Mousa Aya , Teede Helena
Published: December 2022

Context

Pre-clinical evidence suggests that prolactin has important metabolic functions in pregnancy and postpartum, in addition to lactogenic actions.

Objective

To explore the relationship between prolactin and maternal metabolic outcomes in human pregnancy and postpartum, particularly in relation to gestational diabetes mellitus (GDM).

Data sources

MEDLINE via OVID, CINAHL plus, Embase.

Study selection

Eligible studies included women who were pregnant or up to 12 months postpartum, reporting at least one maternal serum prolactin level in relation to key metabolic outcomes including GDM, glycaemic parameters, obesity, and gestational weight gain.

Data extraction

Two independent reviewers extracted data.

Data synthesis

Twenty-six articles were included. Meta-analysis showed no relationship between maternal prolactin levels and GDM status, with a weighted mean difference of -2.14 ng/mL (95% CI -12.54 to 8.27 ng/mL, p=0.7) between GDM and controls in early pregnancy (n=3 studies) and -3.89 ng/mL (95% CI, -15.20 to 7.41 ng/mL, p=0.5) in late pregnancy (n=11 studies). In narrative synthesis of other outcomes (due to study heterogeneity and/or lack of data), prolactin levels were not associated with maternal glycaemic or weight-related parameters during pregnancy, but in the postpartum period (particularly with lactation) a high-prolactin environment was associated with low circulating insulin and beta-cell function, and increased insulin sensitivity.

Conclusions

Current evidence from human studies does not clearly support a relationship between prolactin and metabolic parameters during pregnancy, including with GDM status. Elevated prolactin was associated with lower insulin and beta-cell function and higher insulin sensitivity in the post-partum period, but the direction of causality remains unclear.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier [CRD42021262771].