bluuebunny/crossref_metadata_2025 huggingface dataset:
The method of multi-objective parametric design of magnetic field active canceling robust system for residential multy-story buildings closed to double-circuit overhead power lines
Authors: Kuznetsov B. I. , Nikitina T. B. , Bovdui I. V. , Voloshko O. V. , Kolomiets V. V. , Kobylianskyi B. B.
Published: March 2023

Aim. Development the method of multi-objective parametric design for robust system of active canceling of magnetic field based on binary preference relations of local objective for multi-objective minimax optimization problem. Methodology. Spatial location coordinates of the compensating winding and the current in the shielding winding were determined during the preference-based multi-objective parametric design of systems of active canceling based on solution of the vector minimax optimization, in whith the vector objective function calculated based on Biot-Savart's law. The solution of this vector minimax optimization problem calculated based on nonlinear Archimedes algorithm. Components of Jacobi matrix and Hesse matrix calculated based on multi-swarm multi-agent optimization. Results. Theoretically and experimentally confirmed the effectiveness of reducing the level of the magnetic field in residential multy-storey old building of a double-circuit overhead power transmission lines with a barrel-type arrangement of wires by means of active shielding with two compensation winding. Originality. The method of multi-objective parametric design for robust system of active canceling of magnetic field based on binary preference relations of local objective for multi-objective minimax optimization problem is developed. Practical value. It is shown the possibility to reduce the level of magnetic field in residential multy-storey old building closed to double-circuit overhead power transmission lines with a barrel-type arrangement of wires by means of system of active canceling with two canceling winding to a level safe for the population with an induction of 0.5 μT.
Extended mixed integer quadratic programming for simultaneous distributed generation location and network reconfiguration
Authors: Tami Y. , Sebaa K. , Lahdeb M. , Usta O. , Nouri H.
Published: March 2023

Introduction. To minimise power loss, maintain the voltage within the acceptable range, and improve power quality in power distribution networks, reconfiguration and optimal distributed generation placement are presented. Power flow analysis and advanced optimization techniques that can handle significant combinatorial problems must be used in distribution network reconfiguration investigations. The optimization approach to be used depends on the size of the distribution network. Our methodology simultaneously addresses two nonlinear discrete optimization problems to construct an intelligent algorithm to identify the best solution. The proposed work is novel in that it the Extended Mixed-Integer Quadratic Programming (EMIQP) technique, a deterministic approach for determining the topology that will effectively minimize power losses in the distribution system by strategically sizing and positioning Distributed Generation (DG) while taking network reconfiguration into account. Using an efficient Quadratic Mixed Integer Programming (QMIP) solver (IBM ®), the resulting optimization problem has a quadratic form. To ascertain the range and impact of various variables, our methodology outperforms cutting-edge algorithms described in the literature in terms of the obtained power loss reduction, according to extensive numerical validation carried out on typical IEEE 33- and 69-bus systems at three different load factors. Practical value. Examining the effectiveness of concurrent reconfiguration and DG allocation versus sole reconfiguration is done using test cases. According to the findings, network reconfiguration along with the installation of a distributed generator in the proper location, at the proper size, with the proper loss level, and with a higher profile, is effective.
ESTIMATION OF THE EFFICIENCY OF THE MANAGEMENT SYSTEM OF WATER USE PROJECTS IN THE CONTEXT OF IMPLEMENTATION OF THE SUSTAINABLE DEVELOPMENT STRATEGY
Authors: Grishko Natalya , Yakovenko Yaroslava , Savielova Anna , Soroka Andriy , Liventsova Kateryna
Published: March 2023

The article deals wiith topical issues of a comprehensive assessment of the effectiveness of the water management system in industrial cities of Ukraine. It was claimed that it is advisable to draw attention to assessing the impact of the consequences of the transformation of technogenically altered water systems on the socio-economic safety of industrial cities. It was also noted that an integral part of the implementation of the regional development strategy in the diagnosis of the state of water resources in cities on the territory of Ukraine, the search for optimal ways to neutralize the negative consequences of the activities of economic entities. The monitoring of factors influencing the state of water resources (drinking water in Ukraine’s industrial cities in particular) has been carried out. Accordingly, it was established that the insufficient level of environmental innovations in the industry, as well as the volume of capital investments in wastewater treatment and the development of water protection activities are the factors of restraining safe waste management, reducing the water intensity of GDP (as a partial goal of reducing the resource intensity of production). Taking into account the fact that the effectiveness of measures to form the effectiveness of the water management system in Ukraine’s industrial cities is questionable, an integral model for assessing the effectiveness of the water management system in industrial cities of Ukraine has been developed, which is the basis for the search for optimal ways to neutralize the negative consequences of the activities of business entities. The proposed in the article measures can solve the problem of ensuring the socio-economic security of cities. This study confirms the importance of promoting environmental innovation in the industry, as well as increasing capital investment in wastewater treatment and water conservation. Special attention was paid to the selection of indicators for the integral assessment of the effectiveness of the water management system.
MANAGEMENT OF MARKETING RESEARCH AT THE ENTERPRISE: STRATEGIC ASPECT
Authors: Larka Ludmila , Vasyltsova Svitlana
Published: March 2023

The place of marketing research management in the system of strategic planning is analyzed. The purpose of the article is to systematize the strategic aspects of marketing research management in an unstable business environment. A system of key indicators of the effectiveness of marketing research management at the stages of planning, organization, motivation and control is proposed. It has been determined that the key performance indicators of marketing research management at the planning stage can be: the accuracy of the formulation of the problem and the goals of marketing research, the optimal choice of the method for conducting marketing research, the accuracy of calculating the sample size, the convenience of filling out survey forms, the optimal methodology for analyzing data based on the survey results, accuracy interpretation of the results of marketing research; degree of achievement of the goal of marketing research. The key performance indicators of marketing research management at the stage of organization can be the results of SMART-assessment of marketing research goals, ensuring a representative sample of respondents, adhering to the rules for drawing up survey forms, organizing briefing for interviewers, ensuring the convenience of conducting marketing research, ensuring the variety of marketing information providers. Key indicators of the effectiveness of marketing research management at the motivation stage can be: the interest of the personnel of marketing departments in increasing the client base, the interest of staff in marketing departments in the growth of the number of new customers, the cost of attracting customers, the cost of an order. Key performance indicators of marketing research management at the control stage can be: compliance of marketing research tools with objectives, completeness of the research plan, quality of filling out questionnaires, completeness of solving problems in reports based on the results of marketing research.
ORGANIZATION OF LOGISTICS SERVICE AT MACHINE-BUILDING ENTERPRISES
Authors: Maslak Olga , Trunina Iryna , Gryshko Natalia , Maslak Mariya , Yakovenko Yaroslava
Published: March 2023

The modern approaches to the interpretation of "logistics service", which is considered a set of functions and types of activities; a set of services; labor products; components of customer service; the process of creating goods are analyzed in the article.

The various services to consumers, which are provided in the process of selling finished products of the machine-building enterprise are described in the work.

This study is devoted to the problems of logistics service, considering the peculiarities of the machine-building industry. The types of logistics service for consumers (logistics service for the movement of material flows; information logistics service; financial logistics service; personnel logistics service) related to the technology and organizational structure of service, quality indicators, determination of the optimal level of service are distinguished by authors.

Eight stages of the logistics service system of a machine-building enterprise (from market segmentation, analysis of logistics services of competitors, ranking of services, their structure and priorities to the assessment of the level of logistics service and constant control over the quality of the provided logistics services) are focused at the article and indicators of assessment of the level of logistics service (availability, functionality, reliability) are outlined.
FEATURES OF THE COLLECTIVE METHOD OF MANAGEMENT DECISION MAKING IN RISK CONDITIONS
Authors: Shmatko Nataliia , Karminska-Bielobrova Maryna , Pantelieiev Mykhailo
Published: March 2023

At the stage of economic development, significant changes took place in the field of managerial decision-making. Private business presupposes freedom of action for the owners of organizations to solve their economic problems; therefore, managers at all levels of management are faced with a number of methodological problems. Attention should be paid to the emergence of not only complexity in management, but also requirements for the quality and efficiency of decisions. In the management process, managers strive to find a solution that is objectively beneficial not only to the internal environment, but also to the contact audience of the organization. The relevance of the study is due to the fact that the modern external environment contributes to the emergence of complex problems, the effective solution of which is possible only with the help of methods of collective decision-making.

The adopted management decisions are always projected into the future, therefore, at the time of making a decision, a manager cannot know with absolute certainty how the situation will change. In other words, at the moment of making management decisions, there is a significant element of uncertainty and risk. Uncertainty conditions exist when the leader does not know exactly the outcome that each choice will have. Under risk conditions, the probability of the outcome of each decision can be determined with a known probability. When making management decisions in conditions of uncertainty and risk, it is necessary to carry out a risk analysis. After conducting a risk analysis, in the process of developing management decisions, special risk management techniques are used. This article examines the use of a collective method of making managerial decisions for the optimal achievement of goals and increasing the efficiency of work in an enterprise under conditions of risk.
LABOR COST RATES AND THEIR CHARACTERISTICS
Authors: Kuchina Svetlana , Havrys Olha
Published: March 2023

One of the key means for increasing the efficiency of enterprises and labor productivity is the improvement of system of labor organization and regulation. Literature sources are analyzed and it is found that, despite the broad theoretical and methodological base, there are shortcomings in substantiating new approaches to labor rationing, especially in modern conditions, when the process of developing time standards is almost entirely related to the functions of enterprises. The aim of the study is to adapt to modern production conditions and supplement the concept of labor rationing based on modern trends in the development of science and practice of labor management. It has been established that the degree of consolidation of standards depends on a number of conditions and is characterized by the number of labor actions combined into one complex and the totality of time expenditure categories presented in it. There are a number of classification features by which standards are distinguished. The duration of each set of labor actions depends on many circumstances (factors) that in one way or another affect the change in the amount of time spent. There are two types of factors - qualitative and quantitative. In order to obtain reliable data on the average time spent on the performance of a specific set of labor actions, it is necessary to more fully consider the time spent in combinations of quantitative and qualitative factors encountered in production conditions. The concepts of the time norm, norm of production, norm of labor input are characterized by the fact that they contain the same indicators: working time, the subject of labor (product), the contingent of performers and organizational and technical conditions, and the latter remain constant in all definitions. According to the method of determining labor costs, the norms are divided into technically justified and total. Both of these groups of norms have some similarities, but are fundamentally different in terms of their qualitative characteristics. Materials for calculating technically justified norms are considered. The ways of their improvement and reduction of the execution time of the parts of the considered operations are proposed. The need for a wider introduction of technically justified norms in the practice of labor rationing is substantiated.
OIL AND GAS INDUSTRY ECONOMIC SECURITY LEVEL DIAGNOSTICS
Authors: Shchurov Igor
Published: March 2023

The article is devoted to the assessment and analysis of economic security level in oil and gas industry. An analysis of modern methods of assessing economic security has been carried out. Their main advantages and disadvantages are defined. It was established that the assessment of economic security level should be carried out using a combination of the indicator (coefficient) method and the integral method, since the first of them enables to assess economic security according to the system of indicators, and the second - to make a generalized assessment of the economic security level. A methodology for diagnosing economic security was proposed and its approval was carried out for a privately owned oil and gas enterprise. The level of economic security of the enterprise was established and trend changes at the end of the research period were determined. The duality of interaction between the enterprise and the state in terms of economic and energy security is shown. The method of taxonomic analysis and the theory of fuzzy sets is used to diagnose the economic security of enterprises in the oil and gas industry.
ELŻBIETA DĄMBSKA-ŚMIAŁOWSKA (1924-2021); ARCHITECT, RESEARCHER AND TEACHER
Authors:   Professor emeritus of the Cracow University of Technology. Poland Faculty of Architecture, Kurek Jan
Published: March 2023

Elżbieta Dąmbska-Śmiałowska graduated from and worked at the Cracow University of Technology. Apart from teaching General Building Construction and Material Science courses, she conducted research on historical wooden and masonry buildings. She was a humanist shaped by Eastern Borderlands culture, familial tradition and the experience of the Second World War. Underground education, including university education, became the foundation of her studies in the Kraków School of architecture, her academic work and post of vice dean. Her research was conducted in a team of dedicated co-workers and doctoral candidates.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) и субвариантов Omicron, находящихся под мониторингом, на основе количества их геномов, депонированных в базу данных GISAID за неделю с 04.03.2023 г. по 10.03.2023 г.
Authors: Дмитриева Людмила , Краснов Ярослав , Чумачкова Елена , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: March 2023

В обзоре представлена информация по циркулирующим в настоящее время ва-риантам вируса SARS-COV-2 вызывающих озабоченность (VOC) и субвариантов Omicron, находящихся под мониторингом, геномные последовательности которых размещены в международной базе данных GISAID за неделю с 4 по 10 марта 2023 г.
Monitoreo acústico para la conservación
Authors: Coordinador Equipo
Published: March 2023

Durante el simposio fue posible conocer diferentes trabajos de investigación orientados a responder preguntas ecológicas en pro de la conservación de especies y ecosistemas naturales. Este simposio evidenció el gran potencial que tiene el monitoreo acústico en países altamente biodiversos y con altas tasas de transformación, al ser una herramienta que permite registrar información a escalas temporales y espaciales grandes. Se contó con la presentación de trabajos en insectos, peces, anuros, aves, mamíferos y paisajes sonoros, resaltando el alcance e importancia de esta herramienta en el monitoreo de biodiversidad.
Biomecánica, neuroetología y comportamiento
Authors: Coordinador Equipo
Published: March 2023

Una gran cantidad de especies animales usan señales acústicas para comunicarse e interactuar con otras especies y orientarse en su entorno. Este simposio recopiló una serie de estudios que revelan fenómenos del comportamiento animal, desde la complejidad de los mecanismos neurológicos y biomecánicos. Desde los diminutos oídos en las patas de los grillos hasta los complejos comportamientos modulados por las siringes de las aves, fueron temas de estudio que se convirtieron en los protagonistas y maravillaron a los asistentes del simposio.
Employee Performance: QWL, Communication, and Work Discipline at Detention Center
Authors: Sofa Dina Maria , Astuti Mudji
Published: March 2023

This research aimed to determine the influence of quality of work life (QWL), communication, and work discipline on performance at the Surabaya immigration detention center, Ministry of Law and Human Rights, East Java Regional Office. This was a quantitative research with hypothesis testing, using multiple linear regression analysis with SPSS version 18 for Windows. The sample consisted of 52 staff members at the immigration detention center in Surabaya. Primary data was collected through a questionnaire using a Likert scale that was tested for validity and reliability. The results of this research showed that QWL, communication, and work discipline have a significant influence on employee performance. Additionally, QWL, communication, and work discipline have a simultaneous effect on employee performance.

Highlights :

QWL, communication, and work discipline have a significant influence on employee performance at the Surabaya immigration detention center.

The study used a quantitative research design with hypothesis testing and multiple linear regression analysis to examine the relationship between QWL, communication, work discipline, and employee performance.

The results highlight the importance of addressing QWL, communication, and work discipline in promoting employee performance in detention center settings.

Keywords: Quality of Work Life (QWL), Communication, Work Discipline, Employee Performance, Immigration Detention Center.
Morbidity Profile of Traffic Police Personnel of Vidarbha region of Maharashtra
Authors:   Research Scholar, Department of Anthropology, Mahatma Gandhi Antarrashtriya Hindi Vishwavidyalaya, Wardha 442001, Maharashtra., Sahu Prafull Kumar , Mollick Farhad ,   Professor, Department of Anthropology, Mahatma Gandhi Antarrashtriya Hindi Vishwavidyalaya, Wardha 442001, Maharashtra.
Published: March 2023

Background: Morbidity is a state of disease, disability, or poor health condition due to any cause; it may be referred to as the existence of a disease that affects the person's health condition. Traffic police personnel are involved in the occupation of controlling traffic in urban areas. The physical and social environment of the workplace contributes a significant role in occupational health, as traffic police personnel spend at least 8 to 10 hours a day at work. That's why health is affected by the working environment to a large extent. The lifestyle and food culture likely contribute to the elevated morbidity pattern. Several studies indicate that police officers have a risk of increasing specific diseases related to their occupation and lifestyle. Objective: To assess the morbidity pattern concerning the occupational health of traffic police personnel. Material and Methods: The present study was conducted during the fieldwork of Ph.D., among the Traffic police personnel of Nagpur and Wardha district of Vidarbha region Maharashtra. The procedures contributing to this work comply with the ethical standard as per the University's Ethical comity. The traffic police personnel were told about the study's objective, and their written consent was obtained. Result: The present study revealed significant differences in Age, Height, Weight, and Systolic and Diastolic blood pressure among males and females (p = 0.001). Out of 277 personnel, more than fifty percent of traffic police personnel suffered from Musculo skeleton disorder, followed by respiratory problems (17 percent), obesity, and eye-related problem (both in 14.1 percent). 7.6 percent of traffic personnel suffered from skin infections, 7.2 percent from diabetes, 5.4 percent from heart problems, and 2.5 percent from hypertension (High blood pressure) reported by the traffic police personnel. 26.02% of personnel are Systolic and 45.37% of personnel were found Diastolic hypertensive blood pressure category according to physiological measurement.
Case Study: Frac-Hit Occurrence Prediction in Shale Wells Using Artificial Intelligence
Authors: Mohaghegh Shahab D. , Zamirian Mehrdad
Published: March 2023

A Frac-Hit is defined as the communication between an existing horizontal parent well and hydraulic fracturing treatment of the new well called child well. When a parent well is "hit", it can be very problematic both operationally and economically depending on the severity of the "hit". In industry, a Frac-Hit is considered dominantly a function of well spacing and subsequently the number of wells in a given shale asset that increases, the probability of interference between parent and child wells increases significantly. However, by increasing the distance between the wells, the recovery of hydrocarbon from the shale asset reduces. Commonly used techniques such as Rate Transient Analysis (RTA) and Numerical Reservoir Simulation, inherited techniques from conventional reservoirs, have proven to be unrealistic due to their degree of assumptions and simplifications during modeling and evaluation of unconventional resources (Mohaghegh, 2017, Raterman et. al, 2017, Quintero, 2022). In this case-study, AI/ML techniques, which is a pure data-driven, fact-based method without any assumptions, simplifications, and interpretations, is used to predict and mitigate the Frac-Hit occurrence more accurate than common practices in industry.
Integrated Network Modelling to Accurately Predict Asset Performance and Evaluate Options
Authors: Hill Ramona
Published: March 2023

Modern energy asset planning requires the synthesis of many multi-disciplinary inputs to translate reservoir data into coherent simulations and their associated economic forecasts for effective decision making. Utilizing a nodal network model to integrate well forecasts with the asset's operational considerations allows for improved accuracy of the simulations, better guidance and generation of insights that allow for subsequent optimization of plans and more effective capital allocation.

A novel asset development planning workflow is presented which combines type curves with pad scheduling logic, surface flow constraints, costs, ownership, and price forecasts to model the cash flow of the asset through its full life. Flow capacities, costs, shrinkages, liquid yields, and carbon emissions are input at their representative nodes, enabling dynamic and accurate incremental evaluation. Existing base production and corporate type curve databases are leveraged to streamline the workflow, and several scenarios and sensitivities are examined.

The novel workflow is compared against a more traditional method using average infrastructure costs and high level capacity assumptions.

As a result of enabling more nuanced operational inputs, the nodal network was able to predictively simulate an asset's value within the given constraints and dynamically re-evaluate the full model after inputs were adjusted. For example, the model could automatically reroute production when a constraint was hit, then evaluate the liquid extraction and fee structure based on the new routing. Each iteration's production forecast included the latest base production, well forecasts, drilling schedule shifts, facility throughput constraints, shut-ins expected due to nearby scheduled fracs, third party offtake and fee structures, carbon emission costs, liquid extractions, and "take or pay" penalties. The outcome was a more accurate representation of incremental economics associated with development options, insight into potential optimizations, and improved quality of capital allocation decisions.

In addition, the novel workflow was less cumbersome to manage than the traditional workflow. In the conventional process, obtaining accurate network inputs first requires assumption of the flow path. Any subsequent adjustment to the drilling schedule or type curve can change the production timing and routing, requiring the analysis to be manually redone.

The traditional method of planning from the type well database alone does not allow a practical means of incorporating schedule and flow details, especially when the plan changes frequently or when considering multiple scenarios. The resulting forecast relies upon broad assumptions that may be materially incorrect in some cases, preventing optimization of planning decisions. Recent systems integrations allow sharing of data between tools which enables more powerful computational methods for improved forecasting and decision making.
Natural Gas Powered Direct-Drive Turbine Hydraulic Fracturing Technology Delivers High Power Density and Energy Transfer Efficiency for Environmental, Economic and Operational Benefits
Authors: Rodriguez Guillermo , Rodriguez Ricardo , Martinez Barron Heber , Yeung Tony , Fu Dan
Published: March 2023

In today's hydraulic fracturing operations there is an increasing demand for more rate and pressure resulting in more energy intense operations. Therefore, there is a need for more horsepower (HP) to be available on site. In order to support this, along with the industry's transition into a sustainable and low carbon footprint initiative, companies have devoted great efforts in research and development into developing the next generation hydraulic fracturing equipment. As a result, the first natural gas powered 5,000 HP direct drive turbine fracturing pumper has recently been introduced in North America. The objective of this paper is to provide technical insights on how the direct drive gas turbine technology brings a high-power density and efficient energy transfer solution to deliver operational, economic, and environmental benefits.

The industry had limited success in utilization of the direct drive gas turbine technology in the past. The main obstacles were unreliable and inefficient turbine to pump power transfer mechanism, low power density, and lack of an integrated engineering approach. The advancements in gas turbines and speed reduction technology, coupled with an in-depth application of equipment design knowledge allowed the company to successfully develop the next generation of hydraulic fracturing technology. The technology is a power train consisting of a 5,000 HP gas turbine engine (5,336 HP actual), a robust single stage reduction gearbox, and a 5,000 HP continuous duty pump.

The direct drive turbine technology brings one of the highest power densities and efficient mechanical power transfer designs on the market today. The technology utilizes a split shaft gas turbine to allow for a power gapless powertrain, linear output rpm, and low speed high torque capabilities. A wide variety of fuels can be used including compressed natural gas (CNG), liquefied natural gas (LNG), field gas, and liquid fuel (e.g., diesel). Based on certified third-party emissions data, the direct drive technology is shown to have one of the lowest greenhouse gases (GHG) and Environmental Protection Agnecy (EPA) regulated emissions profiles. At the time of this writing, the first direct drive turbine frac fleet has been deployed in the Haynesville for 2 years and more recently introduced in Canada (Montney and Duvernay).
Solvent Gas Uptake of CO2 and Propane in Heavy Oil for Enhanced Oil Recovery
Authors: Bjorndalen Nancy , Jiang Hong , Jossy W. Eddie
Published: March 2023

Cold heavy oil production utilizes the energy inherent in the reservoir for primary oil production and has been applied with commercial success in the area surrounding Lloydminster. The primary cold production of heavy oil can be expected to produce about 5-10% of initial oil in place before the process becomes uneconomical. Solvent gas injection processes can be utilized for the recovery of remaining heavy oil from post-primary reservoirs. The processes involve the injection of solvents or solvent mixtures into an oil reservoir, dissolution of the solvents or solvent mixtures into the oil and production of the solvent-oil mixture. Mixing of the injected solvents with oil in the reservoir is governed by molecular diffusion, mechanical dispersion and non-equilibrium solvent dissolution/exsolution. A key aspect of exsolution for solvent gas-based heavy oil recovery processes is its stimulation of foamy oil behaviour. Maximizing the solvent gas uptake during the dissolution process is vital for attaining foamy oil behaviour during the exsolution process.

A suite of experiments is presented where CO2, propane and a CO2-propane mixture are injected into both dead and live heavy oil sandpacks at a constant pressure and temperature. The solvent uptake rate was monitored with time. Numerical simulation of selected experiments is also presented.

Interestingly, propane showed a slower solvent uptake rate with live oil than with dead oil in the sandpack, whereas CO2 showed a faster rate. The CO2-propane mixture indicated little rate change between live and dead oil experiments. CT experiments further concluded that propane sorbs faster into dead oil. This indicates that methane interferes with propane sorption into the oil in live oil cases. The numerical study found that a non-equilibrium treatment is necessary in simulating solvent dissolution behaviour.

This study will help in the design of solvent gas-based heavy oil recovery processes such as VAPEX, Thermal Solvent, Hybrid Solvent, ES-SAGD, and Cyclic Solvent Injection (CSI). It provides insight into the concentration of injected solvent with distance into the oil, and the time required for adequate solvent injection and soaking. The volume of solvent gas uptake plays a key role in foamy oil behavour during exsolution, and a solid understanding of the solvent gas uptake by heavy oil can help in optimizing oil recovery from sustained foamy oil drive in the reservoir.
Digitization of Hydraulic Fracturing Operations Enables GHG Emissions Reduction, Operational Efficiency, and Reliability
Authors: Martinez Barron Heber , Rodriguez Ricardo , Rodriguez Guillermo , Alvarez Andres , Yeung Tony , Fu Dan , Aitchison Jeff
Published: March 2023

As the job intensity increases, in the form of flow rate and pressure, there is a continuous need for increased amount of horsepower for hydraulic fracturing operations. Nevertheless, increasing the number of units at the wellsite to achieve this demand in horsepower is an impractical solution when attempting to reduce carbon footprint. Instead, increasing the power density, energy transfer efficiency, and reducing the amount of parasitic loss offers a superior solution with the introduction of the first natural gas-powered 5,000 HP direct-drive turbine fracturing pumps in North America.

A methodology was developed to select this direct-drive turbine technology as the next-generation hydraulic fracturing equipment. The direct-drive pumping unit is equipped with a 5,000 hp continuous duty power end driven by a 5,000 hp dual shaft turbine through a single speed reduction gearbox. This combination provides the most efficient mechanical power transfer efficiency resulting in significant fuel cost savings and reduction in greenhouse gas emissions. In conjunction, a new digital control system has been developed and deployed to enable operational automated functionalities for the pumping unit and backside equipment. This innovative control system provides open interoperable controls, and data analytics for the purpose of eliminating uninformed decisions from pump operators as well as predicting and preventing equipment failures.

The objective of this paper is to provide technical details on how digitization enables operational efficiency, equipment reliability, and emission reduction for the direct drive turbine technology.
Design and implementation of a wireless circuit to monitor body, ambient temperature and vital signs associated with heart in patients, athletes and drivers
Authors: Parandin Fariborz , Heidari Farsad , Rahimi Zahra , Roshani Sobhan , Roshani Saeeid
Published: March 2023

This study aimed to design and construct a bracelet system to measure the skin temperature, range, heart rate of the patients, wirelessly, which can be implemented at the lowest expense and the high cost of attending patients in health centers is reduced. Therefore, a complete automation system can be implemented, which includes review processes, alerts, warnings, contacting patients, dispatching to the site, and patient transfer. In this research, a camera is also embedded in the car to check either the eyes of the driver are closed or open, which detects driver drowsiness and distraction and activates the vibrator in the bracelet. The system is also equipped with a graphical interface on the cell phone during the exercise or at home in order to display the measurements of the above quantities and alert when the quantities are higher than or equal to the desired limit.
Manufacturing bone tissue in space destined for patients on Earth?
Authors: Parfenov Vladislav , Zobkov Yury , Karalkin Pavel , Petrov Stanislav , Pereira Frederico , Koudan Elizaveta , Levin Aleksandr , Golberg Margarita , Fedotov Alexander , Smirnov Igor , Kaprin Andrey , Sergeeva Natalia , Sviridova Irina , Kirsanova Valentina , Akhmedova Suraja , Mamin Georgy , Gafurov Marat , Urlichich Yury , Khesuani Yusef , Komlev Vladimir
Published: March 2023

Space exploration is perhaps one of the most difficult tasks ever undertaken since the existence of mankind. International Space Station (ISS) is a unique instrument for advanced technology research that is not possible anywhere else. Tissue engineering in a space environment where “turnoff” gravity can be done is the most emerging field with high-value targets. The microgravity conditions allow the designing of novel biomaterials that cannot be produced on Earth but benefit Earth. Developing and manufacturing a biomaterial to address a space-based challenge could lead to novel biomaterials that will bring important applications in clinical medicine on Earth and/or for long-duration space missions. Up to today, there are only a handful of emerging biomaterials that have been tested in space, none of which have been used for their eventual function. This work is reporting on advances in space technology via the 3D magnetic assembler approach to have furthered the development of synthetic bone tissue constructs on board the ISS Russia Segment during the expeditions 61/62 with clear evidence of their function in preclinical conditions on Earth. The results have demonstrated both high levels of osteoinductive and - conductivity as well as a ultimate rate of tissue regeneration of space bone grafts.
The effect of distance empowerment program on the sense of coherence among multiple sclerosis patients: a quasi-experimental study
Authors: Arab Farzaneh , Hekmatpou Davood , saeedi Maryam
Published: March 2023

Background: Multiple sclerosis is the most common central nervous system disease that causes permanent disability in young adults. There is no definitive cure for multiple sclerosis, and symptom control is an important part of the treatment of multiple sclerosis patients. This study aimed to determine the effect of distance empowerment programs on the sense of coherence in multiple sclerosis patients.
Methods: This research was conducted on 64 people with multiple sclerosis who were referred to Saveh MS Association in a semi-experimental method in 2020. The random block method divided the research subjects into two control groups (32 people) and intervention groups (32 people). The control group only received routine care from the MS Association, but the intervention group, in addition to the routine care, underwent a distance empowerment program (via WhatsApp, Telegram, and blog) and weekly telephone follow-up for two months. Patients’ sense of coherence in the intervention and control groups was evaluated before and immediately after the empowerment program using Antonovsky's Multiple Sclerosis sense of coherence scale and was analyzed using SPSS software version 23.
Results: In total, the data from 59 samples were analyzed. The mean score of sense of coherence in the intervention group after the implementation of the empowerment program was 68.93 ± 9.99, which showed a statistically significant difference compared to before the intervention (P<0.001). Also, the mean score of the sense of coherence after the intervention was significantly higher in the intervention group than in the control group (P<0.001).
Conclusions: Distance empowerment affects the sense of coherence of patients with multiple sclerosis and has led to an increase in sense of coherence scores after the implementation of the empowerment program.
Brain size mediates the choice of breeding strategy in the Red-backed shrike Lanius collurio
Authors: Bialas Joanna T. , Łukasz Dylewski , Marcin Tobolka
Published: March 2023

Brain size of vertebrates is a trade-off between natural selection for enhanced cognitive abilities and the energetic constraints of producing brain tissue. Processing a large amount of information can be beneficial but is also time-consuming. Whether it comes to the timing of breeding onset or nest-site selection, the choice of breeding strategy can be related to the size of the brain. Our study aims to reveal whether there is a relationship between brain size, timing of breeding, nest-site choice, and breeding success in Red-backed shrike Lanius collurio. We found that the first egg laying date was affected by the size of the female head size, with large-headed females laying eggs later in the breeding season. The study also found that the probability of breeding success increased with increased nest concealment, however, the relationship was negligible in larger-headed males. In turn, nest concealment was affected not by head size but only by breeding onset. The study suggests that the choice of breeding strategy may be mediated by brain size depending on sex: large-headed females may take more time to choose a nesting site, which may delay the onset of breeding, and large-headed males may benefit from, or at least be able to compensate for poor nest concealment.
Intra-articular injection of adipose-derived mesenchymal stem cell line attenuates pain, synovitis and cartilage degeneration in monoiodoacetate-induced osteoarthritis rat model
Authors: Fukuda Yoshitsugu , Niki Yasuo , Ono-Uruga Yukako , Mastsubara Yumiko , Shinozaki Munehisa , Imamura Mika , Yoda Masaki , Matsumoto Morio , Nakamura Masaya
Published: March 2023

Background: Recently, mesenchymal stem cell therapy has emerged as an option for osteoarthritis (OA) treatment. Intra-articular injection of adipose-derived stem cells (ADSCs) is growing in popularity in clinical practice as conservative treatment for OA. The adipose-derived mesenchymal stem cell line (ASCL) established in our institute provides allogeneic ADSCs that are more purified than conventional ADSCs. This study evaluated the therapeutic efficacy of intra-articular injection of the ASCL using the low-dose monoiodoacetate-OA (MIA-OA) model in rats.
Methods: Expression of cell surface markers for ADSCs and the ASCL was examined by flow cytometry. Low-dose MIA-OA model was created in 8-week-old male immunodeficient rats by intra-articular injection of 0.2 mg of MIA on day 0. After MIA injection, treatment group rats underwent intra-articular injection of the ASCL, and control group rats underwent intra-articular injection of ADSCs or vehicle on day 1. All rats subsequently underwent nociception analysis, gait analysis, immunoserological analysis and histopathological analysis.
Results: Flow cytometric analysis suggested that the ASCL consists of a homogeneously stem cell population than ADSCs. Nociception analysis revealed that the ASCL rats had higher pain thresholds than ADSCs control rats. Gait analysis revealed that mean swing duration, swing speed and duty cycle were significantly better in the ASCL rats than in vehicle control rats on day 56. Interleukin-6 (IL-6) levels in synovial fluid were significantly lower in the ASCL rats than in vehicle control rats on days 5 and 56. Histopathological scores for infrapatellar synovitis and cartilage erosion were significantly improved in the ASCL rats than in vehicle control rats on days 5 and 56.
Conclusions: Intra-articular injection of the ASCL providing allogeneic ADSCs attenuated pain, synovitis and cartilage degeneration both in the early inflammatory phase and in a later less-inflammatory phase in low-dose MIA-OA model. The ASCL injection did not induce any adverse reactions, potentially representing an effective and safe therapeutic option for OA.
Obstacles to and opportunities for care collaboration through the utilization of an effective preventive care process for frail older adults: A study protocol for a mixed methods study design.
Authors: Boström Martina , Ranada Åsa Larsson , Wijk Helle , Skott Pia , Andersson Annette Erichsen , Rothenberg Elisabet
Published: March 2023

Background: The gap between the groups in society experiencing good health and those not is increasing. Frail older adults are among the most vulnerable groups. Malnutrition, poor oral health, pressure ulcers and falls are common problems increasing the risk of hospitalization or admission to residential care facilities. An effective preventive care process is therefore needed to prevent such adverse events. Interprofessional care collaboration between the teams in residential care facilities, home help care, primary care, and hospital care is described as being prerequisite for an effective, safe, and effective preventive care process. However, the way in which thisprocess is carried out across Sweden’s municipalities varies. There is also a need to understand how managers in elderly care, interprofessional teams, and older adults themselves perceive how well the process of care collaboration functions. The protocol outlined here describes the design of a study aimed at exploring factors that constitute obstacles to and opportunities for care collaboration within and between different care providers through the utilization of an effective preventive care process for frail older adults in Sweden, based on the quality register Senior alert.
Method: A convergent mixed methods study design will be used combining quantitative (quality registers and open data) and qualitative data (practice-based semi structural interviews and focus group interviews with key informants at various organisational levels in elderly care). The results will provide the foundation for the creation of a model for an effective preventive care process for frail older adults, including improved care collaboration, which will be tested in a pilot study.
Discussion: Frail older adults face a high risk of negative events and hospitalization, which in turn leads to increased healthcare costs and decreased quality of life. There is a knowledge gap with regard to the obstacles to and opportunities for an effective preventive care process regarding these negative events. To increase patient safety and provide equitable care for frail older adults, good collaboration between care providers and the use of quality registers might be of importance.
Patient-derived xenograft models of human non-small cell lung cancer: pre-clinical and clinical factors for consideration
Authors: Peled Nir , Fuchs Vered , Sobarzo Ariel , Masamra Maha , Kezerle Yarden , Linde Liat , Sevillya Gur , Refaeli Yael , Cohen Ahron , Melamed Israel , Azriel Amit , Shoukrun Rami , Raviv Yael , Porgador Angel , Roisman Laila
Published: March 2023

Despite the widespread utilization of Patient-Derived Xenografts (PDXs) as preclinical platforms in lung cancer research, there are concerns regarding their capability to accurately represent the tumor's clinical and molecular features across sequential passages. In this study, we established a Non-Small Cell Lung Cancer (NSCLC) PDX model in NSG-SGM3 mice and assessed clinical and preclinical factors throughout subsequent passages. Our cohort consisted of 40 NSCLC patients, which were used to successfully create 20 patient-specific PDX models in NSG-SGM3 mice. We found that the main factors that contributed to the growth of the engrafted PDX in mice were a higher grade or stage of disease, in contrast to a long duration of chemotherapy treatment which was negatively correlated with PDX propagation. Successful PDX growth was also linked to poorer prognosis and overall survival, while growth pattern variability was affected by the tumor's aggressiveness, primarily affecting the first passage. Pathology analysis showed preservation of histological type and grade; however, Whole Exome Sequence (WES) analysis revealed genomic instability in advanced passages, leading to the inconsistency of clinically relevant alterations between PDXs and biopsies. Multiple clinical and preclinical factors affect the engraftment success, growth kinetics, and tumor stability of patient-specific NSCLC PDXs; thus, their use for prolonged treatment evaluation studies remains questionable.