bluuebunny/crossref_metadata_2025 huggingface dataset:
VARIABILITY OF TRACHEAL BIFURCATION ACCORDING TO MAGNETIC RESONANCE IMAGING
Authors: Adamovych O. , Bachun A. , Rudnytska Kh. , Adamovych O. , Kotsarenko M. , Gaba M.
Published: May 2022

Modern methods of radiological diagnostics allow to visualize in life the structural and topographic peculiarities of the structure of the human body, signiﬁ cantly expanding the range of individual anatomical variability of its individual parts and organs. Detailed study of tracheal bifurcation and structure and topography of the main bronchi by in vivo imaging using computed tomography and magnetic resonance imaging attracts the attention of researchers, as it allows to identify and describe variation series and extreme forms of individual norms of the studied structures. The aim. Elucidation of possible variants of tracheal bifurcation and topography of the main bronchi in individuals of mature age according to magnetic resonance imaging. In the course of the work, an analysis of 18 series of anonymized magnetic resonance computed tomography of the thoracic cavity of the individuals of mature age, performed on a Siemens Avanto 1.5T, followed by processing the results with the MicroDicom operating program in 3D-COR mode. In the study of tomograms, it was determined the magnitude of the bifurcation angle of the trachea and the angles of branching of the right and left main bronchi. In the processed randomized sample, the value of the bifurcation angle of the trachea was 79±2.16°. The angle of branching of the left main bronchus was 133.14±3.52 °, and the right main bronchus – 147.72±3.39°. With the general tendency to the predominance of the right main bronchus, the analysis of a series of tomograms showed that only in 13 people (72.2%) right main bronchus was an extension of the trachea and the angle of its branching was greater than the left main bronchial angle. In 3 persons (16.7%) the values of the angles of branching of the right and left main bronchi were almost the same, and in 2 persons (11.1%) the angle of branching of the left main bronchus from the trachea was greater than the angle of branching of the right main bronchus. Identiﬁ ed variants of bifurcation of the trachea and angles of branching of the main bronchi can be considered as variants of the individual anatomical norm of this area.
NEGATIVE INFLUENCE OF CONTACT OF THE SPERMATIC CORD WITH POLYPROPYLENE IMPLANT ON THE CONDITION OF THE TESTICLE
Authors: Moskalіuk O. , Shkvarkovskyj I. , Grebeniu V. , Kozlovska I. , Biltsan O.
Published: May 2022

Surgery remains the only one way of treatment for inguinal hernias. The frequency of inguinal hernioplasty ranks third place among all operations, accounting for 10-15%. Hundreds of thousands of inguinal hernia surgeries are performed annually in Ukraine, but the results of treatment cannot be considered satisfactory yet. Using of allografts has reduced the number of recurrences of hernias to 3-9%. Method I. L. Lichtenstein became the «gold standard» for inguinal hernia alloplasty. However, inguinal allohernioplasty has a certain percentage of speciﬁ c complications, including circulatory disorders in the testicle, which leads to infertility. In order to study the histological changes of the testicle due to the contact of the spermatic cord with the mesh implant, an experimental study was conducted, which included 38 adult male rabbits. To study the anatomical features of rabbits and control the initial histological parameters, 10 intact animals were operated. In 28 animals, the contact between the spermatic cord and the implant was simulated.Analyzing the obtained experimental data, it should be noted that the animals of the experimental group developed signiﬁ cant circulatory disorders in the testicle, which led to impaired spermatogenesis at all times of observation, as evidenced by the dynamics of the layers of spermatogenic epithelium: 4.0±0.27-7 days, 1.8±0.22-21 days, 8.9±0.22-42 days and 6.8±0.34-90 days. The development of progressive sclerosis and hyalinosis in testicular tissues on days 42 and 90 of the experiment was also revealed, as evidenced by the dynamics of the relative amount of connective tissue stroma of the testis from 16.1±0.81% on day 7 to 19.5±1.03% on day 90 experiment. This is conﬁ rmed by signiﬁ cant changes in the diameter of the tortuous seminal vesicles – from 197.3±3.79 μm at the beginning of the study to 156.1±4.51 μm at the end of the experiment.
Стосовно оцінки рівня громадського здоров’я в України та її регіонах
Authors: Качмарська М.О. , Любінець О.В.
Published: May 2022

Мета роботи: проаналізувати та запропонувати групу показників для оцінки рівня громадського здоров’я в Україні та в регіональному аспекті.Матеріали та методи. Матеріалом дослідження слугували дані Стратегії ВООЗ «Здоров'я для всіх у XXI столітті», ЮНЕСКО, Державної служби статистики України за розділами «Демографічна та соціальна статистика» і «Економічна статистика», Міністерства охорони здоров’я України, міністерств фінансів та економіки України, оперативних відомостей підрозділів охорони здоров’я органів державного управління. Розгляд даних здійснено з використанням методів: бібліосемантичного та системного підходу.Результати. Для оцінки рівня громадського здоров’я в Україні та її регіонах запропоновано використовувати три групи показників: I – демографічні, II – медичної статистики, III – соціального благополуччя. У кожній групі передбачається застосовувати по 7 ключових даних, які у найбільшій мірі дають характеристику як стану медико-демографічних змін так і оцінку благополуччя населення в економічному та освітньому рівні з використанням в т. ч. методу соціологічного опитування. В представленому матеріалі подаються джерела інформації стосовно запропонованих показників.
Vietnam en 2021: el proceso de transformación dentro de la pandemia
Authors: León de la Rosa Raquel Isamara
Published: May 2022

Este informe rescata los principales eventos ocurridos en Vietnam desde el cuarto trimestre de 2020 al tercer trimestre de 2021. El documento se encuentra dividido en tres secciones: política, relaciones internacionales y economía. De acuerdo con estos eventos, se plantea la pregunta de si este país camina o no hacia una transformación a partir de las reformas económicas de Doi Moi, luego de las elecciones dentro del XIII Congreso Nacional del Partido y dado el papel que desempeñan los actores regionales e internacionales que determinan el posicionamiento económico vietnamita y su dinámica dentro de la política internacional. De igual manera, uno de los temas importantes es la revisión de la estrategia seguida por el gobierno respecto a la crisis sanitaria de la covid-19.
Guiding questions for the synthesis of catalyst and its application in selective catalytic oxidation reactions
Authors: Cortés-Ortiz William G. , Guerrero-Fajardo Carlos A.
Published: May 2022

This paper presents a brief history of catalysis, as well as the processes of selective oxidation of hydrocarbons. On the other hand, the basic concepts involved in heterogeneous catalysis are mentioned, emphasizing the role of catalytic materials in chemical oxidation processes and posing a series of guiding questions to be followed when approaching a process catalyzed by solid materials. In the same way, the methods of synthesis of catalysts known in the literature as sol-gel and impregnation are shown, identifying the influence of each stage of preparation with the physical and chemical properties of the materials. Finally, a case study applied to the selective catalytic oxidation of methane and methanol using iron, molybdenum, and vanadium catalytic materials synthesized by the sol-gel method is presented.
High rigid Gd (DO3VA) shows remarkable relaxivity: A novel class of MMI agent engineered for MR analysi
Authors: Pushparaj T. Lurthu , Alexander V.
Published: May 2022

A novel dinuclear gadolinium(III) complex of an amide linked bispolyazatricarboxylate macrocycle (DO3VA) having 2-bromoisovaleric acid pendant arm is reported. The molecular longitudinal relaxivity of the dinuclear complex [Gd2{acamidoet(DO3VA)2}(H2O)2] is 13.23mM–1s–1 which corresponds to a “per Gd” relaxivity of 6.62 mM–1 s–1 (20 MHz, 37 ± 0.1 °C, pH 7). The “per Gd” r1p value is higher than the relaxivity of the clinically approved CAs. The transverse relaxivity (r2p) of [Gd2{acamidoet(DO3VA)2}(H2O)2] is 14.34 mM–1 s–1. The r2p/r1p values of 1.08 indicate that the complex is T1-weighted CAs. The 2-bromoisovaleric acid seems to be an excellent pendant arm for holding Gd(III) metal ion at any pH. The remarkable stability of the complex at various pH and in presence of protein shows that the ligand can be used as functionality in making new CAs for MRI and the amide core is a versatile core molecule for the creation of polynuclear gadolinium(III) chelates and dendrimeric CAs.
Effect of different contrast medium injection protocols for analysis of hepatic computed tomography perfusion in healthy dogs
Authors: Amaha Takao , Ishigaki Kumiko , Ishikawa Chieko , Iizuka Keigo , Nagumo Takahiro , Tamura Kei , Asano Kazushi
Published: May 2022

OBJECTIVE

To evaluate the hepatic CT perfusion (CTP) for determining the appropriate protocol for the dual-input maximum-slope model in dogs.

ANIMALS

5 healthy dogs.

PROCEDURES

Each dog underwent CTP with different contrast medium administration protocols. Combinations of three different injected doses of iohexol (450, 600, and 750 mg/kg) and injection durations (5, 10, and 15 seconds) were used. The CT values at the aorta, portal vein, and hepatic parenchyma were measured to create a time–density curve, and CTP parameters were measured simultaneously on each hepatic lobe using a 320-row multidetector CT scanner.

RESULTS

The maximum peak enhancement at the aorta, portal vein, and hepatic parenchyma was greater with the 750-mg/kg dose than with the 450-mg/kg dose. With an injection duration of 15 seconds, the aortic enhancement peak was less, and the arrival time at the aortic enhancement peak was longer compared to that with a 5-second injection duration. The CTP parameters in the caudate process of the caudate lobe and left lateral lobe differed with different injection durations. The CTP parameters in the caudate process of the caudate lobe, left lateral lobe, and right lateral lobe differed with varying injected doses.

CLINICAL RELEVANCE

Our study demonstrated that rapid administration of the contrast medium was required for quantitative analysis of hepatic CTP in healthy dogs. The CTP parameters differed with respect to the contrast medium administration protocol, and it was necessary to administer the contrast medium within a fixed duration and at a fixed dose to evaluate CTP correctly.
A randomized clinical trial to compare ketamine-butorphanol-azaperone-medetomidine and detomidine-etorphine-acepromazine for anesthesia of captive Przewalski horses (Equus przewalskii)
Authors: Milnes Ellie L. , Skelding Alicia M. , Larouche Cédric B. , Ferro Angelica , Delnatte Pauline , Dutton Christopher , Anderson Neil E.
Published: May 2022

OBJECTIVE

To compare ketamine-butorphanol-azaperone-medetomidine (KBAM) to detomidine-etorphine-acepromazine (DEA) for field anesthesia in captive Przewalski horses (Equus przewalskii).

ANIMALS

10 adult Przewalski horses.

PROCEDURES

A prospective randomized crossover trial was conducted. Each horse was immobilized once with KBAM (200 mg ketamine, 109.2 mg butorphanol, 36.4 mg azaperone, and 43.6 mg medetomidine) and once with DEA (40 mg detomidine premedication, followed 20 minutes later by 3.9 to 4.4 mg etorphine and 16 to 18 mg acepromazine). Both protocols were administered by IM remote dart injection with a washout period of 6 months between treatments. Selected cardiorespiratory variables and quality of anesthesia were recorded. Antagonists were administered IM (KBAM, 215 mg atipamezole and 50 mg naltrexone; DEA, 4 mg RX821002 and 100 mg naltrexone).

RESULTS

All horses were anesthetized and recovered uneventfully. Inductions (DEA, 6.8 min; KBAM, 11.6 min; P = 0.04) and recoveries (DEA, 3.2 min; KBAM, 19.6 min; P < 0.01) were faster with DEA compared with KBAM. Quality scores for induction and recovery did not differ between protocols, but maintenance quality was poorer for DEA (P < 0.01). Clinical concerns during DEA immobilizations included apnea, severe hypoxemia (arterial partial pressure of oxygen < 60 mm Hg), muscle rigidity, and tremors. Horses treated with KBAM were moderately hypoxemic, but arterial partial pressures of oxygen were higher compared with DEA (P < 0.01).

CLINICAL RELEVANCE

Captive Przewalski horses are effectively immobilized with KBAM, and this protocol results in superior muscle relaxation and less marked hypoxemia during the maintenance phase, but slower inductions and recoveries, compared with DEA.
Determination of the minimum alveolar concentration of isoflurane in donkeys
Authors: Escobar André , Dzikiti Brighton T. , Thorogood Jemma C. , Maney Jill K.
Published: May 2022

OBJECTIVE

To determine the minimum alveolar concentration (MAC) of isoflurane in donkeys and characterize recovery from anesthesia.

ANIMALS

7 healthy castrated male adult donkeys.

PROCEDURES

Anesthesia was induced with propofol and maintained under mechanical ventilation with 1.3% isoflurane end-tidal concentration (ETiso). The MAC of isoflurane was determined after a 60-minute propofol washout period using the bracketing method. A continuous noxious electrical stimulation was applied to the oral mucosa for 1 minute or until the donkey moved. The ETiso was increased or decreased by 10% depending on the response, and MAC was defined as the average of 2 ETiso values allowing and preventing movement in response to stimulation. Arterial blood gases were measured during anesthesia and the recovery period. Unassisted recovery was timed, and a quality score was assigned from 1 (very poor) to 5 (excellent).

RESULTS

The mean dose of propofol required for induction was 3.0 ± 0.6 mg/kg. The MAC of isoflurane was 1.44 ± 0.13%. One donkey was excluded from the study because it was still responsive when stimulated at ETiso of 2.8%. Immediately after extubation, the median (range) partial pressure of oxygen in the arterial blood was 63 (minimum to maximum, 46 to 72) mm Hg and 3 donkeys were hypoxemic (partial pressure of arterial oxygen < 60 mm Hg). The median time to standing was 13 (7 to 38) minutes, while the recovery score was 3 (2 to 5).

CLINICAL RELEVANCE

The MAC of isoflurane in donkeys is similar to that reported in other species. Oxygen support should be provided to donkeys during recovery from isoflurane anesthesia to prevent hypoxemia.
An Evaluation of a Language Processor for an African Native Language-based Programming Language
Authors: Olatunji Ezekiel K. , Olabiyisi Stephen O. , Oladosu John B. , Odejobi Odetunji A.
Published: May 2022

The design and prototype implementation of a subset of an African indigenous language-based programming language has been carried out and reported. In this study, an evaluation of the processor developed for the native language-based programming language was carried out in order to assess its level of conformance to the characteristics required of a good software product as set by the international organization for standardization (ISO). The developed language processor was evaluated using some metrics for evaluating the quality of software systems including structural and time complexity. A usability test was also conducted to assess users’ perception of the system concerning its relevance and ease of use. The result of system evaluation indicated that the system contains 1558 lines of code, its cyclomatic complexity is 14 and its asymptotic time complexity is of order big oh O (n3), where n is the size of the input to the system. Over 86% of the participants in the usability test attested to the system’s relevance while the usability rating was 86%. The developed system can be inferred to be of good quality as the results of its evaluation are positively on the high side for satisfying most of the ISO criteria for adjudging a software product as being of good quality. Furthermore, the high usability rating for the system indicates that the programming language whose compiler was evaluated satisfies most of the criteria set by the Department of Defense (DOD) for assessing the ‘goodness’ or otherwise of a programming language.
How does prosodic deficit impact naïve listeners recognition of emotion? An analysis with speakers affected by Parkinson’s disease
Authors: Biassoni Federica , Gnerre Martina , Malaspina Eleonora , Di Tella Sonia , Anzuino Isabella , Baglio Francesca , Silveri Maria Caterina
Published: May 2022

This study aimed to understand the impact of the prosodic deficit in Parkinson’s disease (PD) on the communicative effectiveness of vocal expression of emotion. Fourteen patients with PD and 13 healthy control subjects (HC) uttered the phrase “non è possible, non ora” (“It is not possible, not now”) six times reading different emotional narrations. Three experts evaluated the PD subjects’ vocal production in terms of their communicative effectiveness. The PD patients were divided into two groups: PD+ (with residual effectiveness) and PD− (with impaired effectiveness). The vocal productions were administered to 30 naïve listeners. They were requested to label the emotion they recognized and to make judgments about their communicative effectiveness. The PD speakers were perceived as less effective than the HC speakers in conveying emotions (especially fear and anger). The PD− group was the most impaired in the expression of emotion, suggesting that speech disorders impact differently at the same stage of the disease with varying degrees of severity.
Verksamhetsberättelse 2020
Authors:   Malmö universitetsbibliotek, Kjellberg Sara
Published: May 2022

Under 2020 fick vi lära oss vad resiliens betyder i praktiken. Coronaepidemin blev plötsligt en realitet i början av året. Det innebar ett historiskt beslut av regeringen att den 18 mars låta all högre utbildning i Sverige gå över i ett digitalt läge. Det utmanade universitetsbibliotekets verksamhet på många vis, men att vara resilient betyder att kunna hantera förändringar och att fortsätta utvecklas. En kris kan skapa möjligheter till lärande, nytänkande och innovationer.
Schmutzige Hände und weiße Westen - Schuld und Unschuld in moralischen Extremsituationen
Authors: Wolbert Werner
Published: May 2022

Wer in moralischen Extremsituationen bestimmte Mittel – Tötungen, Folter, Lüge, Korruption – verwendet, um seine Ziele zu erreichen, holt sich «schmutzige Hände». Diese stehen für die Schuld oder Scham der Handelnden, aber bisweilen auch für die Bereitschaft, «sich die Hände schmutzig zu machen», also für mutige oder heroische Taten. Es gibt somit nicht die eine «Moral der schmutzigen Hände». Die Konnotation und ethische Einschätzung sind abhängig von der jeweiligen Handlung und ihrem Kontext und den angewandten ethischen Kriterien. Um Schuld und Unschuld in Dilemmasituationen geht es in diesem Band.
Combatting the Literary Canon through Performance
Authors: Faour Sydney
Published: May 2022

Combatting the Literary Canon through Performance
Ophelia’s Last Word(s) reexamines the literary canon by combatting the trope of “fair and fragile” women.​ Written for Dr. Varadharajan’s English 421 course on adapting Shakespeare, this presentation/performance explores the role of women in Hamlet to offer a new voice to the archetypal shadow maiden, Ophelia. Among many concerns, the rap questions why audiences contemplate Hamlet’s madness but presume Ophelia’s to be authentic. We reinforce harmful gender representations when viewing Shakespeare’s women with a traditional and canonical lens. Examining women as codependent on male figures, emotional, and inept is a lens that perpetuates this standard for modern audiences. Adaptation provides an opportunity to reenvision these women and their fate. Using evidence and information omitted from the text, I offer an alternative ending for Ophelia where she could preserve and fight the problematic representation of fairness and fragility. Adaptation is a valuable way to approach inquiry-based learning because it provides the opportunity to reenvision and reinvent canonical norms that sabotage contemporary efforts at inclusion and equality. The canon is widely accepted and taught in the English discipline but primarily speaks to and from white males. It is intimidating to challenge but also crucial. Therefore, inquiry-based learning like this performance is a spirited attempt to challenge and change the way we learn about Shakespeare. We cannot examine women, representation, and inclusion issues until we reexamine the way women appear in canonical English works. Adaptation is key.
MicroRNA Regulation of Messenger RNA in Lung Neuroendocrine Cell Lines
Authors: Fang Alexis
Published: May 2022

Introduction: Lung neuroendocrine neoplasms (NENs) are rare lung cancers whose pathomechanisms are poorly understood. MicroRNAs (miRNAs) are small, non-coding RNAs (19-24 nucleotides in length) that negatively regulate messenger RNA (mRNA) expression. Each miRNA targets a specific set of mRNAs to regulate. To better understand the molecular biology of lung NENs, we investigated miRNA-mediated mRNA regulation in NEN and non-NEN cell lines.

Methods: NEN and non-NEN cell line expression profiles were relative frequency normalized before undergoing outlier and batch detection. We identified the top 1% most highly expressed miRNAs in all cell lines, NEN cell lines, and non-NEN cell lines. Next, we identified differentially expressed miRNAs and mRNAs between NEN and non-NEN types. We used the Bio-miRTa target prediction algorithm to identify the putative mRNA targets of key miRNAs. Key miRNAs are miRNAs uniquely expressed in NENs compared to non-NENs types. We subsequently determined the likely biological pathways of the predicted targets using the g:Profiler software.

Results: High and differential expression analyses identified miRs-375, -200c, -100, -141, and -7 to be the key miRNAs in lung NEN cell lines compared to non-NEN types. 8014 differentially expressed mRNAs were identified between NEN and non-NEN types. 3916 predicted mRNA targets were identified, which collectively participated in pathways from 21 different categories of cellular function.

Discussion: Comparisons between NEN and non-NEN cell lines identified the key miRNAs of lung NENs to be miRs-375, -200c, -100, -141, and -7. The identified biological pathways of the predicted targets highlight the functional differences between NENs and non-NENs.

Conclusions: Our high and differential expression analyses results identified the key miRNAs in lung NEN cell lines. The biological pathways of the predicted mRNA targets of key miRNAs were also identified. The results generated in this study help to differentiate NENs from non-NENs, which provides a deeper insight into the pathomechanisms of lung NENs. These results also expand our current knowledge in lung NEN biology, which may facilitate the future development of NEN specific drugs and diagnostic tests.
Professional Biography of Samuel Gitterman, Chief Architect and Planner CMHC
Authors: Katz Nathaniel
Published: May 2022

This presentation will overview Samuel Gitterman's professional careers, between 1935 and 1985, focusing specifically on his work with the Canadian Housing and Mortgage Corporation. Gitterman played a central role in the development of the Canadian suburb as Chief Architect and Planner for the CMHC. His work includes the development of prefabricated housing technologies, overseeing establishment of hundreds of suburban subdivisions across Canada, and housing for the military. This presentation will examine the most important aspect of Gitterman’s career, including his efforts on the Cité-Jardin and Crawford Park subdivisions, and his work in the Canadian arctic. Through the use of images, and graphics, Samuel Gitterman’s unique housing and planning style will be investigated.
MÉTODOS CONTRACEPTIVOS: DIFICULDADES DE ADESÃO NO PERÍODO DA ADOLESCÊNCIA
Authors: Araújo Sato Miranda Carolina Terumi , Beretta Darlene , Gimenes Gustavo
Published: May 2022

Introdução: métodos contraceptivos são maneiras, que envolvem uso de medicamentos, cirurgias, modos comportamentais e alguns objetos que têm o objetivo de prevenir/evitar a gravidez. As causas que cercam a dificuldade de adesão aos métodos contraceptivos são diversas. Metodologia: o presente estudo trata-se de uma pesquisa de campo de caráter transversal, exploratório-descritiva quantitativa. Resultados: A escola é um ambiente adequado para realizar a educação em saúde, e trabalhar este assunto, sendo que é o período em que os adolescentes geralmente iniciam a vida sexual. Os adolescentes relatam que não possuem um amplo conhecimento sobre os métodos contraceptivos, além de não saber usá-los de forma adequada. Uma situação que está diretamente relacionada à forma e à qualidade das informações recebidas referente ao assunto. Conclusão: considerando que a pesquisa foi realizada com um curso de graduação da área da saúde é de suma importância focar neste déficit que foi exposto nesta pesquisa; de tal forma que os docentes dessa área possam atuar conseguindo um saber em a respeito do assunto em questão. Contribuindo para a formação de profissionais capacitados a multiplicar informações em saúde de forma correta e abrangente para a população.
TERAPIA COGNITIVO-COMPORTAMENTAL E SUAS CONTRIBUIÇÕES PARA A ABORDAGEM DO LUTO INFANTIL
Authors: Silva Santos Jacqueline da , Pinto Soares Ana Carolina
Published: May 2022

O luto é um processo complexo que acarreta sentimentos dolorosos e confusos, principalmente na infância. Por esse motivo, mostra-se cada vez mais necessária a busca por conhecimentos que embasem a abordagem psicoterapêutica dessa demanda. Neste contexto, destaca-se a Terapia Cognitivo-Comportamental (TCC) como uma abordagem psicológica que apresenta eficácia no tratamento de diversas demandas, através da resolução de problemas do presente por meio da compreensão dos pensamentos, emoções e comportamentos disfuncionais frente a determinadas situações. O objetivo desse artigo consistiu em compreender como ocorre a abordagem da terapia cognitivo-comportamental no manejo do luto infantil por meio de dados coletados através de uma revisão integrativa da literatura, de cunho qualitativo, mediante análise e comparação dos dados coletado e tabulados. Os resultados alcançados evidenciaram a eficácia da terapia cognitivo-comportamental no manejo do luto infantil, por seu caráter psicoeducativo, emocional e cognitivo que auxilia na expressão e vivência do luto pela criança, bem como pelo papel ativo do paciente no processo psicoterapêutico, além da ampla diversidade de estratégias e técnicas lúdicas utilizadas nos protocolos de intervenção na população em questão. Conclui-se com a presente pesquisa que a TCC apresenta-se como uma abordagem eficaz no manejo clínico do luto infantil, diferindo-se do manejo adulto pela utilização de uma linguagem lúdica e participação familiar.
Development of a method for detecting GPS spoofing attacks on unmanned aerial vehicles
Authors:   Institute of Information Technology, Azerbaijan National Academy of Sciences, Abdullayeva Fargana , Valikhanli Orkhan ,   Institute of Information Technology, Azerbaijan National Academy of Sciences
Published: May 2022

As in other vehicles, unmanned aerial vehicles (UAV) mainly use GPS (Global Positioning System) for the provision of navigation. Non-execution of necessary measures on UAV, availability of the devices used in the process of attack may cause GPS spoofing attack on UAV. The quick detection of the attack plays an important role in obtaining safety precautions. The use of artificial neural networks in the detection of such attacks is very convenient. Therefore, in the article new approach based on convolutional neural network (CNN) method is proposed in order to detect GPS spoofing attack. The new approach has been developed for two different types of UAVs. As a result of conducted experiments, high-accuracy detection of GPS spoofing attack has been provided.
Mechanical properties of nanoparticles in the drug delivery kinetics
Authors:   Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA, Assani Kaivon , Neidhard-Doll Amy ,   Department of Electrical and Computer Engineering, University of Dayton, Dayton, OH 45434, USA, Goswami Tarun ,   Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA
Published: May 2022

Nanoparticle formulation is a recently developed drug delivery technology with enhanced targeting potential. Nanoparticles encapsulate the drug of choice and delivers it to the target via a targeting molecules (ex. antigen) located on the nanoparticle surface. Nanoparticles can even be targeted to deeply penetrating tissue and can be modeled to deliver drugs through the blood brain barrier. These advancements are providing better disease targeting such as to cancer and Alzheimer’s. Various polymers can be manufactured into nanoparticles. The polymers examined in this paper are polycaprolactone (PCL), poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and poly(glycolic acid) (PGA). The purpose of this study is to analyze the mechanical properties of these polymers to establish drug delivery trends and model pharmacokinetics and biotransport. We found that, in general, as the melting point, elastic modulus and tensile strength increases, the degradation rate also increases. PLA composite material may be an ideal polymer for drug delivery due to its good control of degradation.
The Imitation Phenomenon The Imitation Phenomenon During the Thinite Age
Authors:   Universitat Autònoma de Barcelona (España), Gardón-Ramos Víctor
Published: May 2022

The most important evolution in the royal architecture of Ancient Egypt was probably the emergence of pyramidal architecture. This revolutionary new concept, started with Netjerkhet’s step pyramid, does not have a clear architectural explanation in the Egyptological context. Most scholars argue that the emerging solar cult was the only clue to this transformation. The present work shows that pyramidal architecture was the result of mixing the clear importance that the solar cult was growing in this historical context and the necessity of the pharaohs to stop the imitation phenomenon that their buildings were suffering by the upper classes during the Early Dynastic Period.
An Overview of the Nature and Functions of the Bovine Goddess Sematweret in the Old Kingdom
Authors:   Universidad de La Laguna (España), Rodríguez Valls Andrea
Published: May 2022

This paper presents an analysis of the Old Kingdom Pyramid Texts that refer to the aurochs-deity Sematweret. This study will consider the writing of her name, her physical attributes and the actions in which she is involved, mainly as the mother of the deceased. For a better understanding of this deity, it is also relevant to examine the relationship with other female deities, such as Nekhbet or the White Crown, and with divinities that appear alongside her, like the goddess Hewenetweret or the god Semawer. The observation of all the elements linked to her is a perfect example of the fluidity of ancient Egyptian myths, and could even indicate the fusion of mythic references in the composition of PT 703 and PT 548, as well as the attribution of some aspects to Nut at an undetermined date prior to the reign of Pepy I.
Getting Gideon Right
Authors:   Deason Criminal Justice Reform Center, Davies Andrew L.B. , Skiles Blane , Metzger Pamela R. , Gursoy Janelle , Romo Alex
Published: May 2022

In Gideon v. Wainwright, the U.S. Supreme Court held that the government must provide a criminal defense lawyer for any accused person who cannot afford one. But for too many people, Gideon's promise remains unfulfilled. In Texas, there are no statewide guidelines about who is entitled to a court-appointed lawyer. Instead, counties create their own rules that create serious gaps in constitutional protection. Getting Gideon Right investigates the financial standards that determine an accused person's eligibility for appointed counsel in Texas county courts. The report reveals a patchwork of county court policies that are both complex and severe.
Síndrome coronariana aguda resultante de fenômenos tromboembólicos em caso de Covid-19: estudo de caso
Authors: Cunha Carolina Souza , Nobre Marlucia do Nascimento , Lima Ingrid Loureiro de Queiroz
Published: May 2022

Objetivo: Relatar e discutir sobre as manifestações tromboembólicas resultantes da infecção pela Covid-19, em particular, Síndrome Coronariana Aguda, ressaltando a importância da investigação, tratamento adequado e prevenção do quadro clinico, visando reduzir risco de agravamento do quadro clínico. O estudo foi aprovado por Comitê de Ética em Pesquisa. Detalhamento do caso: Jovem, 36 anos, sem comorbidades, evolui com dor torácica típica na segunda semana pós infecção por Covid-19, sendo diagnosticado com Síndrome Coronariana Aguda e submetido à investigação do quadro através de exames complementares, que mostraram presença de trombos em artéria descendente anterior e ventrículo esquerdo, resultando em disfunção segmentar do ventrículo esquerdo. O paciente foi submetido a tratamento com anticoagulação e por angioplastia com sucesso. Considerações finais: Eventos tromboembólicos, durante e após infecção por Covid-19, podem existir, o que ressalta a necessidade de investigação, prevenção e tratamento destes, para evitar complicações no quadro clínico dos pacientes acometidos por essa doença. Ainda são necessários estudos mais robustos para determinação desses mecanismos pró-trombóticos e a melhor terapia a ser adotada.
MRI spectrum of avascular necrosis of femoral head in patients treated for COVID-19
Authors: Kachewar Sushil Ghanshyama , Kachewar Smita Sushil
Published: May 2022

Objectives:

The objectives of the study were to analyze the spectrum of avascular necrosis (AVN) of the femoral head as seen in MRI images of patients treated for COVID-19.

Material and Methods:

The different patterns of the findings of AVN of the femoral head as seen in MRI images in 200 patients who received standard treatment for COVID-19 in the recent past and presented with hip pain were analyzed retrospectively.

Results:

No positive findings to suggest any femoral head AVN as per the Ficat and Arlet classification were seen in 94% of cases. Stage IV AVN was seen in 0 cases (0%). Stage I AVN was seen in 6 cases (3%). Stage II AVN was seen in 4 cases (2%). Stage III AVN was seen in 2 cases (1%).

Conclusion:

In patients who have received standard treatment for COVID-19 and who later developed hip pain, the incidence of AVN was seen in 6% of cases. It was mainly seen more in the younger population (<40 years of age) probably due to quick ambulation and return to daily work. Elderly patients were rarely affected. Normal MRI findings were more common in these cases. Among the positive MRI scans of such cases, mild findings of AVN (Stage I) were the most predominant.
Congenital aromatase deficiency – A virilizing masquerade!
Authors: Kulkarni Abhishek J. , Agrawal Poorvi Chandraprakash
Published: May 2022

Congenital adrenal hyperplasia (CAH) is the most common cause of disorder of sex development in an XX individual. While 21-hydroxylase (CYP21A2) gene mutation is the most common subtype of CAH, aromatase deficiency due to mutations in the gene CYP19A1 is a rare subtype. We report a 46,XX infant with virilized external genitalia, no clinical signs of glucocorticoid or mineralocorticoid deficiency, normal 17-hydroxyprogesterone and adrenocorticotropic hormone, and high levels of gonadotropins and testosterone with inappropriately low estradiol and ovarian cysts. Based on this clinical and biochemical consortium, next-generation sequencing was advised, in which a novel mutation in the gene CYP19A1 was identified.
Russian Business Culture in the Conditions of Macroeconomic Uncertainty
Authors: Stozhko Dmitry K.
Published: May 2022

The new social reality developing over the past decades has caused serious internal transformations in the nature and content of economic culture in general, and business culture in particular. In this regard, the relevance of studying various forms, directions and levels of this transformation, as well as searching for solutions that allow purposefully influencing the process of evolution of business culture in the context of the need to improve its social and economic efficiency has increased. The study aims to assess the processes of business culture transformation in the conditions of growing macroeconomic instability, uncertainty and risks. The article examines the evolution of scientific ideas about business culture as a culture of entrepreneurship and active economic activity in the genesis of economic science. There is substantiated the idea of business culture as a culture of creativity and its generalizing nature in relation to other forms of economic culture. The article reveals the general and specific characteristics (features) of business culture. Its transformation is taking place in fundamentally new conditions of social instability and uncertainty both at the communication level (communication environment), in the field of axiology (value thinking and consciousness), and in the field of creative technologies (info-, nano-, bio-, cognitive, etc.). The author outlines the main directions and forms of the business culture transformation in the context of digital economy formation. The article reveals the features of the development of business culture in modern conditions. The growing variety of its models and typologies testifies to their different philosophical and ideological foundations, which objectively hinders the development of universal and generally accepted norms of economic behavior. There are indicated negative and positive characteristics in the transformation of business culture. Achieving the necessary balance between them meets the objectives of the country’s sustainable socio-economic development strategy both in the near future and for a longer period. The article formulates specific recommendations for modernizing the economic education system in the context of the need to develop and improve business culture.
The Factor of Sustainability of Ethnic Culture in the Global World: To the Concept of Cultural Federalism
Authors: Pudov Aleksey G.
Published: May 2022

The article proposes the concept of cultural federalism, which contributes to the sustainability of ethnic cultures in the era of global unification. The new understanding of federalism revives the meanings of modernity, contributing to the synergy of Russia’s multinational culture, overcoming alienation, and disintegration of multiculturalism.

The novelty of the topic lies in the substantiation of the concept of cultural federalism vs ethno-federalism. The concept is adequate to the cultural situation of modern Russia, its multinational cultural capital, capable of countering the secession with the integration model of interaction and mutual enrichment of cultural programs. The cultural federalism contributes to the development of a national Russian idea, the absence of which reduces the effect of national consolidation and nation-building.

The proposed concept serves as a tool for resolving the contradiction between the form and content of the “sleeping” ethnic federalism. The article considers the dialectical self-development of the federation subjects entering the era of organic socio-cultural modernization. This is expressed by the ethno-cultural renaissance in the field of art. Thus, the ethno-modern in the art of Yakutia demonstrates productivity, ensuring the sustainability of the ethnic cultures of the North-East of Russia from the erosion of their moral and spiritual foundations.
Plant Growth Promoting Activity of Paenibacillus alvei WW001 and its antagonistic effects against Phytopathogenic Bacteria
Authors: Laoburin Patcharee , Wimonsiravude Waurawan , Panbangred Watanalai
Published: May 2022

A bacterium strain with nebular growth pattern was isolated from a rice field and was identified as Paenibacillus alvei WW001. The isolate exhibited several plant-growth promoting activities including solubilization of tri-calcium phosphate at 1,152.9 μg/ml after 6 days of cultivation and production of indole acetic acid (IAA) which reached the maximum concentration of 5.1 μg/ml after 4 days of cultivation in nitrogen free medium supplemented with L-tryptophan. In addition, high production of ammonia and siderophore was detected on day 7 of cultivation (1.7 μmol/ml and 60% siderophore units respectively). Gibberellic acid production from a dayold culture in LB broth was quantified to be 79.6 μg/ml. Strain WW001 also displayed an ACC deaminase activity, albeit at a low level. Its cell-free culture supernatant (CFCS) showed antimicrobial activity against bacterial phytopathogen; Pectobacterium carotovorum DoA 263, Xanthomonas campestris DoA 1869 and X. axonopodis at 40, 1280 and 1280 Arbitrary Unit (AU)/ml respectively. Tricine SDSPAGE analysis revealed a 3-kDa peptide associated with the observed inhibitory effect. Treating mung bean seedlings (n=30) with strain WW001 only or mixture of strain WW001 and X. campestris resulted in longer roots and higher total dry weights. Collectively, both in vitro and in vivo results attested that P. alvei WW001 is an efficient plant growth promoting rhizobacterium (PGPR) with a potent activity against bacterial phytopathogen.
A Comprehensive Review on the Potential Use of Immobilized Lipase as Biosensor –Present Scenario and Prospects
Authors: Singh Nandini , Verma Anurag , Kaur Ishman , Chattopadhyay Soham
Published: May 2022

Lipases that catalyze the hydrolysis of triglycerides play an outstanding role in developing biosensors used in various industries. With the latest developments and progress in biotechnology, nanobiotechnology and electronics, the demand for enzyme-based biosensors increases day by day. This review introduces different techniques and methods adopted to develop biosensors from lipase and discusses their properties and characteristics to demonstrate present scope, opportunities and challenges in biosensor technology. A focus of industries has shifted towards eco-friendly, high yield products with high profitability index. The use of enzymes seems to be the golden choice. With this review, we focus on the usage of an immobilized enzyme (lipase) in biosensors. We discuss various deficits in the immobilization and assay techniques, in brief, to bring about attention to the need for advancements in them to increase the overall accuracy of the biosensor in the present scenario.
The Histopathological Analysis of Sodium Arsenite (As3+) Induced Hair Loss and Associated Dermal Changes in C57BL Mice
Authors: Binumon Mangalathettu Thankachan , Najeeb Shahul Hameed , Sreejith Parameswara Panicker
Published: May 2022

Alopecia is a common disease that affects both physiological and psycho-social interaction in humans and environmental pollution contributes to a greater extent. People who live in arsenic polluted regions such as mines and nearby areas are unaware of topical arsenic exposure and its effects. Moreover, the topical application of arsenic on mice skin is not studied yet. Studies are needed to elaborate on the mode of action of arsenic on skin and hair. Thus, the present study aims to characterise the topical application of sodium arsenite (As3+)(14.6 mg/kg bw) on C57BL mice. After the experiment, skin tissues were excised, processed, sectioned and stained with haematoxylin and eosin. The effect of arsenic exposure is manifested by erosion of epidermis, epithelial hyperplasia, hyperkeratosis, lipid peroxidation, sebaceous gland degeneration and inflammatory infiltration of immune cells. The hair shaft is replaced by the keratinised substance in the affected hair follicles. The results revealed that arsenic is detrimental to the healthy growth of skin and hair.
Introduction: Pour une approche des formes linguistiques dans les dynamiques interactionnelles
Authors: Mondada Lorenza
Published: May 2022

Ce numéro est le fruit d’un travail collectif élaboré et discuté à l’occasion d’un colloque de recherche tenu à la Section de Linguistique de l’Université de Lausanne les 18 et 19 novembre 1994. La rencontre était motivée par la volonté de mieux cerner les rapports entre linguistique et analyse conversationnelle. Elle partait en effet du constat que, bien qu’il existe des liens entre les deux courants, ceux-ci restent souvent implicites – la linguistique ne tirant pas toujours les conséquences théoriques d’un travail rigoureux sur les données conversationnelles et l’analyse conversationnelles tendant à sous-évaluer l’examen des traces linguistiques.
Représentations lexicales floues et construction interactive du sens
Authors: Lüdi Georges
Published: May 2022

Cette étude explore une voie d’accès aux représentations lexicales plutôt négligées, que je sache, dans la recherche récente, à l’exception d’une étude de Quasthoff/Hartmann (1982). S’inspirant de l’ethnométhodologie, elle exploite le fait que les interlocuteurs désignent eux-mêmes, dans le cadre de la bifocalisation de la conversation (Bange 1987), certains éléments du discours comme faisant partie de l’information lexicale.
Roman Jakobson: deux programmes de fondation de la slavistique, 1929/1953
Authors: Avtonomova Natalja , Sériot Patrick
Published: May 2022

Natalja AVTONOMOVA, Institute of Philosophy, Moscow : «R. Jakobson : two founding programs of slavistics, 1929 - 1953»

This paper shows the specificity of Jakobson's ideas about the Slavic world, in their relations to classical slavophilism (which considered that the Western Slavs, for religious reasons, did not really belong to the Slavic world) and to eurasianism (as represented by N. Trubetzkoy, who denied to the Slavic world any existence other than the purely linguistic).

In Prague Jakobson is deeply involved in comparing Russian scientific ideas and corresponding Czech ideas. He strives to include into the scope of Eurasianism Western Slavic problematics, which had been expelled from studying by the Slavophils and Trubetzkoy.

The «American» Jakobson, on the other hand, deals with the problem of Slavdom from another geographical and epistemological point of view. The Slavic cultural community is presented through the literature of the Western, Southern and Eastern Slavs, and Jakobson studies how the community of language determines a certain degree of cultural community.

The «Eurasian» line of Jakobson's work is a missing link between the slavophile approach of the Slavic world and the conception he had after 1939, as a political, linguistic and cultural unit.
Fonctionnalisme et thérapeutique
Authors: Gadet Françoise
Published: May 2022

Françoise GADET, University of Paris-X-Nanterre : «Functionalism and therapeutics»

At about the same time (around 1930) a number of works written by different linguists, representing various schools of thought in various countries, all highlight a concern with language change and in particular with the notion of causality (Jakobson, Frei). Each in his own way is aiming to develop a functionalist perspective on a system, in which teleology and function will play – in varying degrees – an important part, thorough the incorporation of the idea of the «speaking subject».

This article starts from a close reading of Jakobson and uses current notions of language change, in order to shed light on the relation between Jakobson's work and that of other linguists in the 1930s.
Ta mère... Notes sur un changement de pratique discursive
Authors: Adam Jean-Michel
Published: May 2022

Une très singulière pratique discursive a été observée par le socio-linguiste américain William Labov, dans le chapitre 8 du premier volume de la traduction française de son second grand livre : Le Parler ordinaire (1978). Il s’agit de ce qu’on appelle : les injures ou insultes rituelles, ou encore les vannes ou les charres.