bluuebunny/crossref_metadata_2025 huggingface dataset:
Yapay Zekâ ve Robot Teknolojisine Yönelik Risk Algısı Üzerine Nitel Bir Çalışma
Authors: TOKSOY ÇAĞAL Meltem , KESKİN Yahya
Published: November 2023

İnsanlık bugün, önü alınamayan bir hızla ilerleyen ve öncekilerden farklı yeni bir teknolojik gelişme olan yapay zekâ ve robot teknolojisinin olduğu çağı deneyimlemektir. Bu teknolojinin, öngörülebilen ve öngörülemeyen olumlu ya da olumsuz pek çok etkileri olacağı uzmanlar tarafından tartışılmaktadır. Bu çalışmada, laboratuvar ortamlarından çıkarak insanların gerek günlük yaşamında gerekse çalışma hayatında yer almaya başlayan, kişilerin ve toplumların yaşamlarını etkileyen yapay zekâ ve robot teknolojisinin riskleri ile ilgili bireylerin görüşlerinin tespiti amaçlanmıştır. Bu amaç doğrultusunda nitel yöntem kullanılmış olup farklı demografik özelliklere sahip 15 kişiye yarı yapılandırılmış görüşme tekniği uygulanmıştır. Görüşmeler neticesinde elde edilen veriler betimsel analiz tekniği ile analiz edilmiştir. Analiz sonucunda bu teknolojinin oluşturduğu risklerin tüm katılımcıları etkilediği ve bu risklerin dağılımında farklılıklar olacağı yönünde görüşler olduğu tespit edilmiştir. Ayrıca bu teknolojiye yönelik risk öngörülerinde bireysel farklılıklar olduğu görülmüştür. Alanyazın taraması yapıldığında yapay zekâ ve robot teknolojisinin risk algısına yönelik sınırlı çalışma olduğu tespit edilmiştir.Bu çalışmanın sonucuna göre, katılımcıların YZ ve robotik gelişmelerden kaygı duydukları, giderek bireyselleşmenin ve bağımlılığın, gözetleme ve denetimin aratacağı, güçsüz ülkelerde savunma ve güvenlik zaafiyeti yaratacağı, sosyal ilişkilerde risk oluşturacağı ve katılımcıların risk algılarının farklılaştığı sonucuna ulaşılmıştır.Elde elde edilen verilerin bu alandaki boşluklardan birini doldurması ve yapılmak istenen sonraki çalışmalara rehberlik edecek olması çalışmanın önemini ortaya koymaktadır.
Arbitration-Court training and procedural statement
Authors: Gonzalez Ewerton Zeydir , Dendasck Carla Viana , Silva Adonias Osias
Published: November 2023

Arbitration is one of the conflict resolution methods provided for by law that removes the primacy of the Judiciary to decide disputes between natural or legal persons, leaving the task of settling the matter in question to be judged by a third party freely chosen by the parties. To do so, the arbitration procedure must be established, which depends on the mutual agreement of the parties, provided they are capable, and the subject matter to be submitted to this type of resolution should be a right that can be relinquished. Through the arbitration agreement, which can be arranged through a clause or an arbitration commitment, the parties can define the procedures that will govern the arbitration process and guide the arbitrators’ actions. If the parties do not define these procedures, they can adhere to the rules of the chosen arbitration institution where the arbitration will take place, or leave it to the discretion of the arbitrators to define the procedures. It is important to emphasize that, despite all the freedom granted to the parties, they cannot, by explicit legal provision, suppress the right to due process and a full defense. In order to provide a better understanding of the arbitration process, this work intends to cover all its stages, from the legal principles that surround it, evaluating recent legislative changes, through the establishment of the arbitration procedure and the actions involved in the instruction and judgment.
Enfermedad Celíaca: una revisión
Authors: Santos Amadhonnis Pereira dos , Santos Tiago França dos , Ferreira Jostein Henrique Cavalcanti , Dias Cláudio Alberto Gellis de Mattos , Araújo Maria Helena Mendonça de , Dendasck Carla Viana , Oliveira Euzébio de , Fecury Amanda Alves
Published: November 2023

La Enfermedad Celíaca (EC) es una enteropatía inmunomediada en respuesta a la ingesta de gluten en individuos genéticamente predispuestos, lo que causa una síndrome de malabsorción. Esta revisión tiene como objetivo conceptualizar la EC, describir su fisiopatología, resaltar su epidemiología, detallar los cuadros clínicos asociados, mostrar el enfoque diagnóstico y explicar el tratamiento. Para ello, se buscaron trabajos en inglés, portugués y español de los últimos cinco años en las siguientes bases de datos: PubMED, LILACS y SciELO, utilizando las siguientes palabras clave: “doença celíaca” y “celiac disease“. La búsqueda resultó en 175 artículos, con 40 trabajos seleccionados después del tamizado y evaluación. Los resultados muestran que la EC es una enfermedad que afecta aproximadamente al 1% de la población mundial, que puede diagnosticarse a cualquier edad, pero con una sintomatología más típica en los niños y más atípica en los adultos. La patogénesis involucra el factor genético HLA DQ2/DQ8, la ingesta de gluten, la formación de anticuerpos anti-transglutaminasa tisular y una reacción inflamatoria que daña el duodeno, afectando su función absorbente. Los síntomas típicos incluyen diarrea crónica, distensión abdominal, pérdida de peso, retraso en el crecimiento y deficiencia de vitaminas. Los síntomas atípicos incluyen dermatitis herpetiforme, anemia ferropénica refractaria, retraso en la pubertad, infertilidad y enfermedades neurológicas. El diagnóstico implica un cuadro clínico sospechoso, serologías para autoanticuerpos, pruebas genéticas y biopsia duodenal. El tratamiento se realiza con una dieta sin gluten de por vida. A pesar de estar bien caracterizada, la EC aún se diagnostica insuficientemente y se requieren estudios adicionales.
ECONOMIC GLOBALIZATION: NEW CHALLENGES AND STRATEGIES FOR FINANCIAL RISK MANAGEMENT
Authors:   State Tax University, Ananieva Yuliia
Published: November 2023

The article examines the impact of globalization on the economy and the challenges it poses to financial risk management. In the context of the growing interdependence of world markets, the main characteristics of globalization and its impact on macroeconomic, liquidity, credit and other risks are investigated. The article emphasizes the need for an integrated approach to risk management, including investment diversification, insurance, constant monitoring of the market situation, and the development of effective strategies for responding to potential threats. The findings emphasize the importance of flexibility and a systematic approach to financial risk management in the context of globalization to ensure stability and competitiveness in the global market. Attention is focused on geopolitical risks, which are becoming more and more relevant in the conditions of globalization, and their impact on international business. The authors consider various techniques and tools for identifying, analyzing and minimizing these risks. Special attention is paid to risk management strategies, such as portfolio diversification, use of professional managers, insurance and other financial instruments. In the conditions of constantly changing market dynamics and the uncertainty of the global economic environment, companies must be ready for rapid adaptation and change. Only a systematic approach to risk management, based on a deep analysis and understanding of global trends, can ensure long-term stability and success in the international arena. The article also considers the role of technology in identifying and responding to financial risks. Modern analytical tools such as Big Data, artificial intelligence and machine learning provide an opportunity to more accurately predict market trends and adapt to them in real time. In addition, the article considers the importance of international cooperation and regulation in the field of financial risk management. In an interconnected world, common norms and standards can promote stability and reduce potential risks for global investors. Success in financial risk management in today's world requires not only deep knowledge and understanding of market mechanisms, but also the ability to innovate, flexibility and readiness for continuous learning. Only this approach will allow companies to effectively adapt to the rapidly changing conditions of the globalized economic environment.
REGULATORY AND LEGAL SUPPORT FOR THE MANAGEMENT OF THE ECONOMIC ACTIVITY OF HEALTH CARE INSTITUTIONS
Authors:   Dniprovsky State Technical University, Hurzhyi Polina
Published: November 2023

The purpose of the article is the analysis and systematization of the current regulatory and legal framework, which regulates the economic activity of health care facilities in order to determine approaches to its improvement. The relevance of the normative and legal regulation of the management of the activities of health care institutions has been determined. Problems of a medical and economic nature are outlined, the solution of which should be aimed at the management process of health care. The conceptual principles of the state-legal regulation of the activity of health care facilities (purpose of the task, objects, subjects, methods) have been defined. The goal of regulatory and legal support for the management of health care activities has been established, which consists in ensuring the full coherence of all internal processes related to the impact on material, labor and financial resources for the implementation of economic activities aimed at achieving the goals and performance of tasks by the health care institution. The levels of regulatory and legal support for the management of health care activities are highlighted. The types of health care facilities were analyzed according to different forms of ownership (state, communal, private, mixed) and organizational and legal forms (state or state and communal or communal non-commercial enterprises) in accordance with the norms of the Civil Code of Ukraine and the Economic Code of Ukraine. The requirements established for institutions in order to obtain a license for medical practice are highlighted. It is pointed out the need for accreditation of health care facilities in accordance with their established criteria. The norms of the Tax Code of Ukraine regarding the taxation of state and private health care facilities have been analyzed. The conditions of taxation in the simplified and general form for private health care institutions are determined. Deficiencies in regulatory and legal support, which hinder the effective operation of health care facilities, have been identified. Separate areas of medical law have been identified, which should be amended and improved, which will have a positive impact on the activities of health care facilities as a whole.
WAYS OF INCREASING THE EFFICIENCY OF INNOVATIVE DEVELOPMENT MANAGEMENT OF CONSTRUCTION ENTERPRISES
Authors:   Kyiv National University of Construction and Architecture, Hazukin Andrii
Published: November 2023

The article presents a theoretical analysis of the evaluation of the effectiveness of management of innovative development of construction enterprises. The purpose of the article is to conduct a theoretical analysis of approaches to assessing the effectiveness of management of innovative development of construction enterprises in the context of the implementation of the concept of sustainable development. It was noted that the construction sector is characterized by a high level of competition and significant barriers to entering the market. To ensure competitiveness and success, construction companies must implement the latest approaches to the design and execution of construction works, management of construction enterprises. The main ways of achieving construction efficiency have been determined, in particular, the optimization of construction processes, the implementation of lean construction methodology, the development of technological innovations, the expansion of cooperation between interested parties, and the support of sustainable and ecological construction practices. Implementation of these strategies can significantly increase construction productivity, reduce costs, and improve project outcomes. These approaches can also contribute to the long-term stability and viability of the industry by ensuring the rational use of resources, minimizing environmental impact and improving the overall quality of buildings. The main aspects of the evaluation of the effectiveness of the management of the innovative potential of the construction enterprise are considered: economic, organizational, social, technical-technological, ecological, marketing, which have the corresponding indicators and specifics. Separate quantitative and complex indicators for evaluating the organizational effectiveness of innovative development management, as well as indicators that transform qualitative parameters in the digital dimension, are presented. To evaluate the effectiveness of innovative development, it is proposed to use complex indicators that integrate value and quantitative indicators of statistical reporting.
FINANCIAL AND INVESTMENT MECHANISMS FOR ENSURING SUSTAINABLE ECONOMIC GROWTH OF UKRAINE
Authors:   Yuriy Fedkovych Chernivtsi National University, Verstiak Andrii
Published: November 2023

Financing of ecological and economic growth involves the implementation of specialized mechanisms and approaches that take into account the special requirements of sustainable development and effective use of natural resources. At the same time, in the conditions of global challenges and significant internal disparities, the field of so-called environmental finance is characterized by a number of problems. The analysis revealed that the beginning of Russia`s war in Ukraine led to additional challenges and changes in the field of environmental financing, since the crisis situation and the determination of budget priorities significantly affect the distribution of financial resources and planned activities in this field. State budget expenditures on defense as of June 2023 amounted to 52.75%, and they will increase as soon as the possibility of additional financing of its needs appears. At the same time, the funds of macro-financial international aid are directed to the general fund of the budget, from where all costs are financed, and there is also an agreement with the EU that their funds go to humanitarian needs and are not spent on financing the spheres of security and defense. The analysis of the current situation, as well as full-scale military actions in Ukraine, leads to the conclusion about the need to intensify the financing of green initiatives and projects, as well as the development of appropriate mechanisms for tools. According to the formalization, the relevant financial mechanisms should be implemented at several levels, in particular, similarly, through the prism of two models: sectoral and territorial models. Ensuring the financing of ecological and economic growth is an important task for any state, as it contributes to the balanced development of the economy, the preservation of natural resources, and the improvement of the quality of life of citizens. A number of measures aimed at expanding investment support are proposed, namely, the development of a comprehensive strategy for ecological and economic development, the creation of an attractive and stable investment climate, the development of innovative, digital technologies and the implementation of green solutions should be priorities, the state can attract funds through the issue of "green bonds", development of partnerships between the public sector, private companies and international organizations.
MODERN BUSINESS COMMUNICATIONS WITH REPRESENTATIVES OF EUROPEAN COUNTRIES: COMPARATIVE CROSS-CULTURAL ANALYSIS
Authors:   Oles Honchar Dnipro National University, Privarnikova Irina , Goley Julia ,   Oles Honchar Dnipro National University
Published: November 2023

The article outlines the main theoretical aspects of communications in general, as well as business communications in particular. The difference between business communications and traditional communicative interaction in modern society is indicated. The concept of the terms "communication" and "business communication" is given. A diagram of the communication process is presented, its components are characterized: sender, recipient and message. The existing main types of business communications are described, as well as methods and models of communicative interaction (linear, transactional, circular). The types and forms of communications are presented. The main forms of business communications are characterized: conversation, negotiations, dispute, meeting, etc. The existing types of business cultures are described, according to the Lewis classification (monoactive, polyactive, reactive), and their features are described. The main features for conducting a cross-cultural analysis of the specifics of business communications in European countries have been identified, namely: attitude to time and business, features of organizing meetings, features of conducting meetings, language used, features of choosing a partner, attitude to dress code, attitude to presentation business cards, attitude towards gifts, etc. Modern types of business cultures inherent in various European countries are identified. For a cross-cultural analysis of the characteristics of business communications, the business culture and business etiquette of such countries as: Austria, Belgium, Germany, Great Britain, Italy, Spain, France, Greece, etc. were analyzed. It has been established that in European countries two main types of business culture models predominate: mono-active and poly-active. In countries with a mono-active business culture (Austria, Germany, Great Britain, Belgium, Latvia, etc.), business communications are quite strictly regulated, punctuality, formalism, strict hierarchy and adherence to traditions are important, conservatism. In countries with a multi-active business culture, business communications are less formalized, openness and friendliness, the establishment of close friendly relations, etc. are valued. It has been proven that for successful intercultural interaction in business, the language of communication, awareness of the picture of the world (judgments and stereotypes, behavior patterns, attitudes towards life and work, etc.) of the country from which the interlocutor arrives and directly in which communication is carried out, compliance customs and principles of business culture and business etiquette of the host country
PERCEPÇÃO DOS CLIENTES DE UMA ACADEMIA DE MUSCULAÇÃO SOBRE O ATENDIMENTO DO PROFISSIONAL DE EDUCAÇÃO FÍSICA
Authors: Simões Bezerra Alana , Nikolas Pereira Mendes Gabriel
Published: November 2023

O atendimento do Profissional de Educação Física vem sendo um critério cada vez mais importante no âmbito das academias, pois é uma das condições que mais se destacam quando se trata de competência técnica e rendimento. O papel do profissional de Educação Física quanto à satisfação dos clientes na academia, é um fator de grande importância, pois, a qualidade no atendimento gera melhores resultados e satisfação dos clientes. O objetivo dessa pesquisa é identificar a percepção dos praticantes de musculação sobre o atendimento do profissional de Educação Física. Trata-se de uma pesquisa de campo, do tipo exploratória e de abordagem quantitativa, participaram 64 alunos matriculados em uma academia da cidade de Patos-PB com idade entre 18 e 34 anos. Foi utilizado um questionário semiestruturado, contendo 16 questões objetivas. Os dados obtidos serão analisados de forma quantitativa, será utilizado o programa IBM, Statistical Package for the Social Sciences (SPSS), versão 25. Os resultados do estudo mostraram que a percepção dos alunos com relação a assiduidade (40,30%), pontualidade (46,80%), apresentação pessoal (43,50%), atenção do profissional (40,30%), competência técnica (41,90%) e incentivo do professor (27,40) foi boa. Assim, conclui-se que os alunos de uma academia da cidade de Patos – PB tem boa percepção sobre o atendimento do Profissional de Educação Física.
Three Directions in Resonance Medicine
Authors: Viktor Praznikov
Published: November 2023

In our previous publications, two directions in resonance medicine were presented - 1. Resonance of destruction and 2. Resonance of creation. This article discusses three directions in resonance therapy: 1. Resonance of destruction, 2. Resonance of creation, 3. adaptive-trophic role of the sympathetic division of the autonomic nervous system in restoring the functions of various organs and systems and in the resonance treatment of various diseases. Resonance of destruction is presented in the effective treatment of oncological diseases, HIV, stones, cysts in various organs, and inflammatory processes. The resonance of creation is realized in the effective treatment of degenerative diseases, mainly in the elderly and senile age - the treatment of type 1 diabetes, all autoimmune diseases, Parkinson's disease, Alzheimer's disease, multiple sclerosis and other diseases. The adaptive-trophic role of the sympathetic nervous system, its high importance for restoring the function of various organs and in the treatment of numerous diseases has been established.
Length-Weight Relationships of Five Indigenous Fish Species From the Daya Bay, China
Authors:   Shenzhen Base of South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shenzhen, China, Song Jiang , Guo Xiaoqi ,   Guangdong Agricultural Technology Promotion Center, Guangzhou, China, Ye Zhenbiao ,   Zhuhai Changfeng Aquatic Seed Technology Co., LTD, China, He Ziying ,   Guangzhou Yutou Aquaculture seedings Co.LTD, China, Wang Jieyi ,   Shenzhen Base of South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shenzhen, China
Published: November 2023

The present study describes new estimates of length-weight relationships (LWRs) for 5 indigenous fish species collected from the South China Sea, Daya Bay (22°30′-22°50′ N, 114°29′ -114°49′ E). The fishes were collected quarterly (Spring, Summer, Autumn and Winter) from 2019 to 2021 with multi mesh composite gill nets (35.0 m long, 4.0 m high, and mesh size 15.0–116.0mm). Total length (to nearest 0.01 cm, L) and total weight (to nearest 0.01 g, W) were determined. The estimate of coefficient b for species ranged positively from 2.489 to 4.146, respectively. The coefficient of determination (r2 ) for each species with range of 0.93-0.97. Findings of this study have implications in the management and conservation of the species- specific fisheries resources within the geographical range.
Neuropsychological Aspects and Interventions for Internet Addiction in Adolescents with Asperger's Syndrome - Narrative Review
Authors:   Hellenic Open University,Greece, Theodoratou Maria ,   Neapolis University Pafos, Cyprus, Kougioumtzis Georgios A. ,   Hellenic Open University,Greece,   Neapolis University Pafos, Cyprus,   National and Kapodistrian Univeristy of Athens, Greece, Kaltsouda Anna ,   Hellenic Open University,Greece,   University of Ioannina, Greece, Katsarou Dimitra ,   University of Aegean, Greece, Siouti, Zoi ,   National and Kapodistrian Univeristy of Athens, Greece, Sofologi Maria ,   University of Ioannina, Greece, Tsitsas George ,   Neapolis University Pafos, Cyprus,   Harokopeion University of Athens, Greece, Flora Katerina ,   University of Macedonia, Greece
Published: November 2023

Internet addiction poses a significant concern for adolescents, particularly those diagnosed with Asperger's syndrome. Although empirical research focusing on adolescents with Asperger's syndrome is limited, existing findings reveal several neurocognitive and mental health factors contributing to internet addiction. Impulsivity, attention deficits, social skills deficits, cognitive rigidity, and co-occurring anxiety and depression are among the key aspects identified. Understanding these factors is essential for developing effective interventions. This review discusses neurocognitive and mental health aspects of internet addiction in adolescents with Asperger's syndrome as well as potential interventions targeting these aspects to promote healthy internet use and overall well-being in this unique population.
Probable Vascular Dementia in the Tropics: A Study of Twenty-Six (26) Observations at Conakry University Hospital
Authors:   Department of Neurology, University Hospital of Conakry, Guinea., Djigué Barry Souleymane , Tafsir Diallo Mohamed , Lamine Touré Mohamed , Mbara Diallo Souleymane , Guelngar Carlos Othon , Bademba Diallo , Namory Camara , Foksouna Sakadi , Boubacar Diallo Mariama , Adama Koné , Madandi Hinami , Eugen Lamah , Karim Telico Barry Abdoul , Fodé Abass Cissé , Amara Cissé
Published: November 2023

Introduction: In tropical environments, the diagnostic certainty of vascular dementia is difficult to establish due to under-medicalization, delays in consultation and above all the inadequacy of exploration methods. Material and methods: We analyzed the records of 153 patients hospitalized for dementia syndrome over a period from January 1, 2016 to December 21, 2021 in the Neurology Department of the Centre Hospitalo-. Universitaire de Conakry. Dementia status was assessed according to the Clinical Evaluation Scale (ECD), Confirmed by Mini Mental State Examination (MMSE<24) cognitive tests or Neuro, behavioral Cognitive Status Examination (NCSE) score. Results: 26 (twenty-six) patients fulfilled the DSM-IV criteria for vascular dementia, based on the association of dementia and cerebrovascular disease certified by the presence of focal neurological signs of vascular origin and imaging data. Conclusion: this study shows a non-stereotyped clinical and etiological profile of the spectrum of vascular dementias in the tropics, in a context of under-medicalization. These results are useful for diagnostic and prognostic discussion.
Unicornuate Uterus With Pre Ruptured Rudimentary Horn Pregnancy At 15 Weeks Gestation: Case Report
Authors:   Department of Obstetrics and Gynecology Tobruk Medical Center, Saleh Rezeg Hawa ,   Tobruk Libya, Elmahaishi MS ,   Department of Obstetrics and Gynecology Tobruk Medical Center; Tobruk Libya
Published: November 2023

To describe the diagnosis and management of one case of pre rupture rudimentary horn pregnancy of unicornuate uterus in the early second trimester by clinical suspicion, sonography, and laparotomy. This paper presents a rare case in which a rudimentary horn pregnancy was suspected clinically at 15 weeks gestation with moderate to severe abdominal pain and diagnosed by sonographic criteria which revealed an empty uterine cavity with a pregnant uterine horn and confirmed by laparotomy. Which revealed a right unicornuate uterus and pre rupture a noncommunicating left rudimentary horn containing a gestational sac, fetus, and placental tissue. The patient underwent surgery, and the pre rupture rudimentary horn pregnancy with fallopian tube was resected and repair of the damaged uterine wall was made with no complications. The patient conceived spontaneously eight months after surgery and her antenatal care was regular without complications until 36 weeks gestation presented with mild left iliac fossa pain. Her vaginal examination revealed she is in labor; the patient prepared and operated the next day as elective cesarean section; the baby and the placenta were delivered without any difficulty. Rudimentary horn pregnancy is a dangerous kind of ectopic pregnancy and is considered as very rare condition which make difficulty in understanding the disease. Most of the clinicians instructed to be focus on prenatal ultrasound for an earlier diagnosis and management which results in a reduction in risk of maternal morbidity and mortality. Additionally, MRI can be used to confirm the diagnosis before an invasive procedure is undertaken.
Osteonecrose de cabeça de fêmur em paciente portadora de anemia falciforme: Relato de caso
Authors: Cruz Nicole Jenniffer Giffoni , Siqueira Stella Maris de Lima , Cortez Paulo José Oliveira , Marotti Jaqueline Brandão Guerreiro
Published: November 2023

A anemia falciforme (AF) é uma hemoglobinopatia autossômica recessiva ocasionada pela mutação no cromossomo 11 em que se observa a substituição do ácido glutâmico pela valina, levando à produção da hemoglobina variante S (HbS). A osteonecrose é uma complicação óssea da AF que comumente ocorre no úmero e fêmur, propiciando isquemias sucessivas, devido aos quadros de vaso-oclusão. O diagnóstico inicia-se com a anamnese e exame físico voltados para queixas de dor na região do fêmur e piora da artralgia ao deambular, bem como a radiografia de quadril. Além disso, deve-se considerar a presença de fatores de risco como uso prolongado de corticoides e alcoolismo. O objetivo do presente artigo é relatar um caso de relevância diagnóstica e terapêutica envolvendo uma jovem portadora de AF que evoluiu com crise álgica, sendo constatada osteonecrose asséptica em cabeça de fêmur (ONCF). O quadro iniciou-se com crises álgicas de alta intensidade localizadas no quadril esquerdo, irradiando para a região femoral, que pioravam com a deambulação. A etiologia da doença é multifatorial, estando associada a situações que comprometem a irrigação sanguínea da cabeça femoral, como o uso prolongado de corticoides, sequelas e traumas, HIV, discrasias sanguíneas e, principalmente, a AF. A associação existente entre a AF e a osteonecrose é bem estabelecida na literatura, no entanto, essa complicação ainda é considerada rara, sendo de grande relevância descrever casos clínicos bem-sucedidos, diagnósticos precoces e tratamentos cirúrgicos da ONCF, os quais foram determinantes para a melhora do quadro e reinserção da paciente.
Utilização da toxina botulínica no tratamento da depressão: Uma revisão integrativa
Authors: Pereira Maria Thereza de Oliveira Romão , Bontempo Carla Rocha , Santos Eduarda Rocha , Brandão Ulisses Rezende
Published: November 2023

A depressão se manifesta como um conjunto de sintomas que comprometem a qualidade de vida do indivíduo. Devido à falta de êxito de determinados tratamentos em alguns pacientes, injeções de toxina botulínica, na região glabelar, se tornou uma possível alternativa para colaborar no alívio de sintomas associados a esse transtorno psiquiátrico. Trata-se de uma revisão integrativa acerca da utilização de toxina botulínica no tratamento da depressão. Realizou-se o cruzamento dos descritores “Toxina Botulínica”; “Depressão”; “Emoções”; “Feedback Facial” e “Auto Estima” nas seguintes bases de dados: Scientific Electronic Library Online (Scielo), National Library of Medicine (PubMed MEDLINE) e Google Scholar. O local das injeções faciais de BoNT/A é relevante para o sucesso do tratamento da depressão. Injeções glabelares de BoNT podem reduzir os sintomas de depressão leve a moderada. A toxina botulínica também pode interferir na propriocepção das emoções, de acordo com a teoria do feedback facial. Os efeitos adversos associados à BoNT são, em geral, leves e transitórios. Os sintomas depressivos tendem a ressurgir após alguns meses das injeções, indicando que a BoNT pode ser mais eficaz quando utilizada como terapia complementar. Os resultados de uma meta-análise demonstram que as injeções de BTX-A têm se mostrado eficazes como tratamento adjuvante na Depressão Maior (MDD). A BTX-A apresenta-se como uma alternativa de muita relevância quanto ao tratamento à depressão. No entanto, há necessidade de futuras pesquisas para fornecer uma compreensão mais profunda.
Estratégia, conceito e produtividade de leite e queijo caprino: Uma revisão bibliográfica
Authors: Oriente Suelma Ferreira do , Silva Pedro Ivo Soares e , Ramos Nayara Jessica da Silva , Santos Rebeca Morais Silva , Gusmão Thaisa Abrantes Souza , Gusmão Rennan Pereira de , Pasquali Matheus Augusto de Bittencourt
Published: November 2023

O leite caprino tem grande importância socioeconômica na produção de alimentos no Nordeste brasileiro, sendo a pecuária caprina uma das principais atividades realizadas na região Semiárida. É importante ressaltar que, o Semiárido Paraibano se caracteriza por apresentar condições ambientais de terras áridas e de baixa pluviosidade, onde os caprinos têm no bioma Caatinga sua principal fonte alimentar, que, somado ao reconhecido valor nutricional do leite caprino, o faz assumir papel na alimentação complementar das crianças dessa região. Sendo o leite caprino um alimento de alta digestibilidade e de elevado valor nutricional, o consumo deste produto vem aumentando devido à procura por derivados lácteos (com ênfase aos queijos) e aos problemas de alergia ao leite bovino. Logo, o estudo tem como objetivo conceituar o leite e queijo caprinos em termos de inovação, tendências, produtividade e impacto na saúde através de uma revisão bibliográfica narrativa. A abordagem metodológica permitiu o uso de estudos experimentais e não experimentais para ter uma compreensão completa sobre a temática proposta. O leite caprino apresenta uma composição rica em proteínas, vitaminas, com destaque para a vitamina A, gordura, extrato seco, carboidratos e sais minerais, os quais são essenciais aos seres humanos.  Portanto, torna-se de interesse o aprofundamento de estudos sobre as potencialidades funcionais dos compostos presentes no queijo caprino, possibilitando alternativas de processamento da matéria-prima, o leite caprino.
Estilo e qualidade de vida dos estudantes de Medicina do estado de Sergipe
Authors: Oliveira Lucas Augusto Reis Pereira de , Debbo Alejandra , Nascimento Leila Maria Lemos
Published: November 2023

O estilo de vida é caracterizado por padrões de comportamento identificáveis que podem ter um efeito profundo na saúde da população e está relacionado com diversos aspectos que refletem as atitudes, os valores e as oportunidades na vida das pessoas Sendo assim, faz necessário o desenvolvimento de hábitos de vida saudáveis, com a prática de atividades físicas e uma boa alimentação, atreladas aos bons relacionamentos sociais, prática de sexo com segurança, o não consumo de álcool e drogas, além do controle do estresse e ansiedade. Nos alunos universitários, particularmente os que cursam Medicina, a carga horária intensa, a diminuição das atividades de lazer e do convívio social, os conteúdos extensos, somados ao frequente contato com doenças e morte, favorecem a estes um comprometimento na qualidade de vida. O presenta artigo trata-se de um estudo transversal e quantitativo com coleta de dados por meio de formulário. Feito com acadêmicos de medicina estado de Sergipe que tem como finalidade, portanto, avaliar o impacto na qualidade de vida e saúde dos estudantes de medicina durante sua graduação, usando-se um questionário autoaplicável chamado “Estilo de Vida Fantástico”, atrelado a variáveis como idade, período do estudante, sexo, diagnóstico pregresso psiquiátrico e uso de drogas psicoativas.
Interação cultivar x ambiente e estabilidade em cultivares de milho (Zea mays L.) de baixo custo
Authors: Boa António Fanuel , Wate Joaquim , Macuácua Dércia Teresa Eugénio , Neves Amílcar Dina Julião , Sozinho Celso Dos Filipes Arquina Fernandes
Published: November 2023

Estudos da expressão gênica através da interação genótipo x ambiente e estabilidade são utilizadas por programas de melhoramento de plantas para identificar cultivares que apresentam comportamento previsível e ótimo para posterior recomendação de cultivares. No presente trabalho objetivou-se identificar cultivares de milho com crescimento e produtividade estáveis e com baixo custo de aquisição por meio da avaliação da interação cultivar x ambiente e estabilidade produtiva no município de Vilankulo, Moçambique. Foram avaliadas quatro cultivares de milho em seis ambientes compostos pela combinação de duas épocas de cultivo e três níveis de adubação nitrogenada. Os experimentos foram conduzidos nas épocas agrícolas 2019/20 e 2020, na área experimental da UEM-ESUDER. Em cada experimento utilizou-se o delineamento em blocos casualizados (DBC), em esquema fatorial 4 x 3, com três repetições, sendo quatro cultivares e três níveis de adubação nitrogenada. Concluiu-se que a ordem de respostas no crescimento e produtividade das cultivares altera na mudança de época e nível de adubação aplicada. A cultivar VPAL é a mais produtiva e estável para o município de Vilankulo, Moçambique.
Vivências de um projeto de extensão com pessoas idosas na Atenção Primária à Saúde
Authors: Corral Amanda Curiel Trentin , Oliveira Naila Albertina de , Silva Diego Ximendes da , Miura Carla Roberta Monteiro , Sala Danila Cristina Paquier , Lima Karine  Victória dos Anjos , Braz Giovanna Maria Ianeczék , Okuno Meiry Fernanda Pinto
Published: November 2023

De acordo com o artigo 6º da Constituição Federal de 1988, toda pessoa tem direito ao lazer e à saúde, tais práticas têm sido oportunizadas pelo Projeto de Extensão Recreação para Pessoas Idosas (Recrear). O projeto leva atividades de lazer e ações de educação em saúde à população idosa e aos seus cuidadores. Este trabalho relata a experiência das ações promovidas pelo projeto Recrear na UBS Vila Mariana em São Paulo/SP, em 2022. Trata-se de um relato de experiência das ações do projeto na UBS Vila Mariana, em São Paulo, SP. A equipe foi constituída por treze graduandos de enfermagem, uma pós-graduanda e sete docentes da Escola Paulista de Enfermagem (EPE) pertencente à Universidade Federal São Paulo (UNIFESP). Constituindo-se um grupo participativo de pessoas idosas assistidas pela UBS o que permitiu o vínculo entre extensionistas e público-alvo. Durante os encontros foram desenvolvidas 17 atividades como, por exemplo: jogos de tabuleiro, festa junina, auriculoterapia, meditação e ação educativa “Diet e Light”. Assim, as ações executadas nos permitiram a manutenção da capacidade funcional e a socialização das pessoas idosas; oportunizou o enfrentamento do preconceito contra a pessoa idosa; aprimorou a formação acadêmica e contribuiu para o envelhecimento saudável. Em suma, o projeto tem cunho educativo, cultural e científico que articula, de forma indissociável, o ensino, a extensão, a pesquisa, a assistência e a comunidade viabilizando uma relação transformadora entre instituição, universidade e sociedade.
O uso dos medicamentos produzidos a partir de plantas medicinais para o tratamento de ansiedade
Authors: Medrado Andréia Santos , Oliveira Letícia Furlanetti Jeckstet , Santos Jânio Sousa
Published: November 2023

A ansiedade é um transtorno mental comum em todo o mundo, afetando a qualidade de vida das pessoas. Além das terapias convencionais, como terapia psicológica e farmacoterapia, o uso de medicamentos derivados de plantas medicinais está se tornando uma opção crescente no tratamento da ansiedade. Plantas como Kawa-kawa, maracujá e valeriana têm propriedades ansiolíticas, atuando no sistema nervoso central para promover o relaxamento e alívio dos sintomas de ansiedade. No entanto, é essencial que haja evidências científicas sólidas para avaliar a eficácia, segurança e possíveis interações dessas plantas com outros medicamentos. Estudos clínicos e pesquisas experimentais estão em andamento para investigar os efeitos das plantas medicinais e seus mecanismos de ação. Os medicamentos fitoterápicos representam uma integração bem-sucedida da ciência contemporânea com a tradição de uso de plantas medicinais. Eles oferecem uma abordagem terapêutica complementar que desempenha um papel relevante no cuidado com a saúde, proporcionando uma alternativa segura e eficaz para tratar a ansiedade e outras condições. No entanto, é fundamental que seu uso seja orientado por profissionais de saúde qualificados, pois, mesmo sendo naturais, podem interagir com outros medicamentos ou desencadear efeitos adversos em circunstâncias específicas. Portanto, o estudo destaca a importância de continuar pesquisando e explorando o potencial das plantas medicinais no tratamento da ansiedade.
Long-term trend of near-surface air temperature lapse rate over the Chinese mainland during 1961-2018
Authors: Qin Y , Ren G , Zhang P , Zhan Y , Zhang S , Xue X
Published: November 2023

The near-surface air temperature lapse rate (SATLR) is a result of surface energy balance, and the long-term trend of SATLR is linked to elevation-dependent warming (EDW). The long-term trend of SATLR in China’s mainland was examined in the present study. It was found that the regional average values of annual, autumn, and winter SATLR anomalies in Tmean, Tmax, and Tmin decreased significantly during the period of 1961-2018. In terms of spatial distribution, most of the annual SATLR trends in Tmean across China’s mainland are negative. In spring, positive SATLR trends in Tmean are widespread in the northern mountainous areas of China, while in winter, strong negative trends are found in some areas of the central and eastern parts of the Tibetan Plateau and the Yunnan-Guizhou Plateau. Most of the negative annual SATLR trends in Tmax occur in the central part of China, but in the southwestern part of China for Tmin. Widespread negative SATLR trends in Tmin are usually found in winter, especially in the Hengduan Mountains of Southwestern China and the eastern part of the Tibetan Plateau. The significant positive SATLR trends in Tmax are observed in spring, mostly distributed in northern mountainous areas. In the context of global and regional warming, the long-term trend of SATLR has the potential to detect differences in altitude responses to climate change on a small spatial scale, and to explore the local effect of EDW.
Pharmacology of Berberine and Its Metabolites, Is It the Natures Ozempic or Imatinib?
Authors: Singh Naresh Kumar , Dhanasekaran Muralikrishnan , Kumar Arun HS
Published: November 2023

Background: Berberine, a naturally occurring alkaloid, is widely explored for several health benefits, including weight management and metabolic disorders. The major pharmacological action of berberine is reported to be by activation of AMP-activated protein kinase, while its other clinical outcomes are devoid of clear mechanism of action/s. Hence in this study a detailed pharmacology of berberine and its two major metabolites (berberrubine, and jatrorrhizine) in humans was evaluated using well established Insilco tools. Materials and Methods: The targets of berberine and its metabolites were identified in SwissTargetPrediction server and their affinity was assed using AutoDock vina 1.2.0. The binding pockets of the highest ligand receptor combinations was assessed using the PrankWeb: Ligand Binding Site Prediction tool. Results: Kinases, enzymes and family A GPCR’s were identified as the top three target category of berberine and its metabolites. ROCK2, PIK3CD, KCNMA1, CSF1R, and KIT were observed to be the high affinity targets of berberine and its metabolites with affinity values of <4 uM. The affinity of berberine and its metabolites against all AMPKs and lipid/glucose regulator targets (LDLR, DDP4 and PCSK9) were >10 uM. The IC50 value of berberine and its metabolites against ROCK2 was the least (<1 uM), while their other high affinity targets (PIK3CD, KCNMA1, CSF1R and KIT) showed IC50 values <5 uM. Conclusion: The diverse range of protein targets and the observed novel high affinity targets (ROCK2, PIK3CD, KCNMA1, CSF1R and KIT) offer valuable insights into the potential mechanisms of action and therapeutic effects of berberine and its metabolites in various disease conditions, which warrants validation in suitable efficacy analysis studies.
Аграрна освіта у сільськогосподарських навчальних закладах Херсонської губернії другої половини 19 – початку 20 ст.
Authors: Trygub Oleksandr
Published: November 2023

Метою статті є окреслення загальних тенденцій становлення аграрної освіти другої половини 19 – початку 20 ст. у межах Херсонської губернії; визначення кола ключових сільськогосподарських навчальних закладів, їх виникнення та розвиток у зазначений період; характеристика соціальної та вікової складової контингенту учнів тощо.

Наукова новизна: узагальнено відомості з питання становлення аграрної освіти у Херсонській губернії у дорадянський час; сформовано соціальну картину учнів, яка свідчить про переважно селянську спрямованість аграрної освіти.

Висновки. З початком реалізації Селянської реформи все актуальнішим поставало питання підвищення ефективності сільського виробництва, що напряму було пов’язано із поширенням агрономічних знань і підготовкою професійних агрономів.

В останній чверті 19 ст. увага прогресивних кіл суспільства – земських органів, громадських організацій і приватних осіб до розвитку нижчої сільської профтехшколи неухильно зростала й об’єднувалися їхні зусилля щодо створення навчальних закладів. У Херсонській губернії ключову роль у відкритті навчальних аграрних закладів і подальшому їхньому розвиткові відігравали земства, громадські об’єднання та приватна ініціатива. Держава, у розрізі підтримки й розвитку аграрної освіти, виступала здебільшого одним із інвесторів, регулятором і контролюючим органом, виконуючи в їх започаткуванні другорядну роль.

Не дивлячись на постійну нестачу коштів, слабку навчально-методичну, дидактичну й організаційно-правову базу аграрні навчальні заклади зробили суттєвий внесок у становлення системи підготовки кваліфікованого кадрового потенціалу сільського господарства регіону. Окрім того, нововідкриті заклади зробили певний внесок до наукових пошуків у в аграрній сфері, допомагали в організації зразкових полів, упроваджували нові сільськогосподарські культури, закладали нові сади, виноградники тощо.

Несли сільськогосподарські навчальні заклади і просвітницьку роль. На початку 20 ст. традиційним стало проведення на їх базі різного роду курсів (для агрономів, вчителів, селянства тощо) з викладанням знань із сільського господарства; а Російське товариство з поширення освіти між євреями відряджало учителів єврейських шкіл до Новополтавки «для ознайомлення з постановкою навчання природознавству» і т.д.

Фінансування. Стаття підготовлена за результатами фундаментального дослідження «Соціокультурний простір України другої половини ХІХ – першої третини ХХ ст.: селянський світ» (номер державної реєстрації: 0123U101600) за підтримки Національного фонду досліджень України.
Advances of nanoparticle-mediated diagnostic and theranostic strategies for atherosclerosis
Authors: Lin Lin , Chen Lin , Yan Juan , Chen Peirong , Du Jiahui , Zhu Junpeng , Yang Xinyu , Geng Boxin , Li Lang , Zeng Wen
Published: November 2023

Atherosclerotic plaque remains the primary cause of morbidity and mortality worldwide. Accurate assessment of the degree of atherosclerotic plaque is critical for predicting the risk of atherosclerotic plaque and monitoring the results after intervention. Compared with traditional technology, the imaging technologies of nanoparticles have distinct advantages and great development prospects in the identification and characterization of vulnerable atherosclerotic plaque. Here, we systematically summarize the latest advances of targeted nanoparticle approaches in the diagnosis of atherosclerotic plaque, including multimodal imaging, fluorescence imaging, photoacoustic imaging, exosome diagnosis, and highlighted the theranostic progress as a new therapeutic strategy. Finally, we discuss the major challenges that need to be addressed for future development and clinical transformation.
Cartilage organoids and osteoarthritis research: a narrative review
Authors: Zeng Daofu , Chen Yeping , Liao Zhidong , Wei Guizheng , Huang Xiajie , Liang Rongyuan , Lu William W. , Yi Dan , Chen Yan
Published: November 2023

Osteoarthritis (OA) is one of the most common degenerative joint diseases, significantly impacting individuals and society. With the acceleration of global aging, the incidence of OA is increasing. The pathogenesis of osteoarthritis is not fully understood, and there is no effective way to alleviate the progression of osteoarthritis. Therefore, it is necessary to develop new disease models and seek new treatments for OA. Cartilage organoids are three-dimensional tissue masses that can simulate organ structure and physiological function and play an important role in disease modeling, drug screening, and regenerative medicine. This review will briefly analyze the research progress of OA, focusing on the construction and current development of cartilage organoids, and then describe the application of cartilage organoids in OA modeling, drug screening, and regeneration and repair of cartilage and bone defects. Finally, some challenges and prospects in the development of cartilaginous organoids are discussed.