bluuebunny/crossref_metadata_2025 huggingface dataset:
Combination of Multi-Temporal Sentinel 2 Images and Aerial Image Based Canopy Height Models for Timber Volume Modelling
Authors: Schumacher Johannes , Rattay Margret , Kirchhöfer Melanie , Adler Petra , Kändler Gerald
Published: August 2019

Multi-temporal Sentinel 2 optical images and 3D photogrammetric point clouds can be combined to enhance the accuracy of timber volume models on large spatial scale. Information on the proportion of broadleaf and conifer trees improves timber volume models obtained from 3D photogrammetric point clouds. However, the broadleaf-conifer information cannot be obtained from photogrammetric point clouds alone. Furthermore, spectral information of aerial images is too inconsistent to be used for automatic broadleaf-conifer classification over larger areas. In this study we combined multi-temporal Sentinel 2 optical satellite images, 3D photogrammetric point clouds from digital aerial stereo photographs, and forest inventory plots representing an area of 35,751 km2 in south-west Germany for (1) modelling the percentage of broadleaf tree volume (BL%) using Sentinel 2 time series and (2) modelling timber volume per hectare using 3D photogrammetric point clouds. Forest inventory plots were surveyed in the same years and regions as stereo photographs were acquired (2013–2017), resulting in 11,554 plots. Sentinel 2 images from 2016 and 2017 were corrected for topographic and atmospheric influences and combined with the same forest inventory plots. Spectral variables from corrected multi-temporal Sentinel 2 images were calculated, and Support Vector Machine (SVM) regressions were fitted for each Sentinel 2 scene estimating the BL% for corresponding inventory plots. Variables from the photogrammetric point clouds were calculated for each inventory plot and a non-linear regression model predicting timber volume per hectare was fitted. Each SVM regression and the timber volume model were evaluated using ten-fold cross-validation (CV). The SVM regression models estimating the BL% per Sentinel 2 scene achieved overall accuracies of 68%–75% and a Root Mean Squared Error (RMSE) of 21.5–26.1. The timber volume model showed a RMSE% of 31.7%, a mean bias of 0.2%, and a pseudo-R2 of 0.64. Application of the SVM regressions on Sentinel 2 scenes covering the state of Baden-Württemberg resulted in predictions of broadleaf tree percentages for the entire state. These predicted values were used as additional predictor in the timber volume model, allowing for predictions of timber volume for the same area. Spatially high-resolution information about growing stock is of great practical relevance for forest management planning, especially when the timber volume of a smaller unit is of interest, for example of a forest stand or a forest district where not enough terrestrial inventory plots are available to make reliable estimations. Here, predictions from remote-sensing based models can be used. Furthermore, information about broadleaf and conifer trees improves timber volume models and reduces model errors and, thereby, prediction uncertainties.
An Examination of the Variation in Estimates of E-Cigarette Prevalence among U.S. Adults
Authors: Levy David T. , Yuan Zhe , Li Yameng , Mays Darren , Sanchez-Romero Luz Maria
Published: August 2019

Introduction: Accurate estimates of e-cigarette use are needed to gauge its impact on public health. We compared the results of online and traditional, large scale surveys and provide additional estimates from the Population Assessment of Tobacco and Health (PATH) survey, with the aim of assessing the extent of variation in prevalence estimates. Materials and Methods: We searched the peer-reviewed literature for nationally representative estimates of U.S. adult e-cigarette prevalence, and developed our own estimates from waves one, two, and three of the PATH survey. We compared estimates by age, gender, cigarette smoking status, and e-cigarette use intensity both between online and traditional surveys and among the traditional surveys. Results: For specific years, online surveys generally yielded higher adult use rates than most traditional surveys, but considerable variation was found among traditional surveys. E-cigarette prevalence was greater for less intensive than for more intensive use. Levels of use were higher among current and recent former cigarette smokers than among former smokers of longer quit duration and never smokers, and by those of younger ages. Conclusions: Considerable variation in e-cigarette use estimates was observed even for a specific year. Further study is needed to uncover the source of variation in e-cigarette prevalence measures, with a view towards developing measures that best explain regular use and transitions between the use of e-cigarettes and other tobacco products.
Bladder Health Experiences, Perceptions and Knowledge of Sexual and Gender Minorities
Authors: Hardacker Cecilia T. , Baccellieri Anna , Mueller Elizabeth R. , Brubaker Linda , Hutchins Georgia , Zhang Jory Luc Yimei , Hebert-Beirne Jeni
Published: August 2019

While recent efforts have been made to understand the bladder health experiences, perceptions, and knowledge of cisgender adolescent females and women, virtually nothing is known about the bladder health experiences of people who identify as sexual and gender minorities (SGMs). A community-based participatory research approach using a focus group methodology to engage 36 adult participants who identify as SGM, including individuals who identify as gender non-conforming, queer, transgender (trans) men, or lesbian, in one of six focus group discussions on bladder health. Using directed content qualitative data analysis from the six unique focus groups, three interrelated themes were revealed: gender socialization of voiding behavior and toilet environment culture producing identity threats, and risks to gender affirmation; consequences of hetero-cis normative bathroom infrastructure necessitating adaptive voiding behaviors; and, physical and psychosocial consequences of chronic anxiety and fear are associated with voiding experiences. Insight on how SGMs navigate voiding behaviors, toilet experiences, and health care seeking is needed to assure that bladder health promotion activities are inclusive of this population’s needs.
Remission of Type 2 Diabetes Mellitus after Bariatric Surgery: Fact or Fiction?
Authors: Tsilingiris Dimitrios , Koliaki Chrysi , Kokkinos Alexander
Published: August 2019

Although type 2 diabetes mellitus (T2DM) has been traditionally viewed as an intractable chronic medical condition, accumulating evidence points towards the notion that a complete remission of T2DM is feasible following a choice of medical and/or surgical interventions. This has been paralleled by increasing interest in the establishment of a universal definition for T2DM remission which, under given circumstances, could be considered equivalent to a “cure”. The efficacy of bariatric surgery in particular for achieving glycemic control has highlighted surgery as a candidate curative intervention for T2DM. Herein, available evidence regarding available surgical modalities and the mechanisms that drive metabolic amelioration after bariatric surgery are reviewed. Furthermore, reports from observational and randomized studies with regard to T2DM remission are reviewed, along with concepts relevant to the variety of definitions used for T2DM remission and other potential sources of discrepancy in success rates among different studies.
Land Use Eco-Efficiency and Its Convergence Characteristics Under the Constraint of Carbon Emissions in China
Authors: Yang Haoran , Wu Qun
Published: August 2019

By defining the connotation of land use eco-efficiency, land use eco-efficiency from 2003 to 2015 was calculated on the basis of the mixed directional distance function, and its spatial convergence analyzed using a spatial econometric model. Results showed that (1) the land use eco-efficiency in most regions of China was relatively ineffective—only Guangdong and Guangxi were relatively effective—and the spatial distribution of efficiency levels in each region was polarized. (2) Sigma and beta convergences were observed in land use eco-efficiency in China, and land use eco-efficiency in each province had an influence on the other. (3) The convergence rate of the eastern region was the same as that of the national region (0.164). The convergence rates of the central, western, and northeast regions were 0.181, 0.183, and 0.189, respectively, which were all higher than the national convergence rate. (4) Scientific and technological strength and industrial structure significantly promoted the improvement of land use eco-efficiency and steady development of land use in China.
Striking a Balance: Physical Activity, Screen-Viewing and Homework during the Transition to Secondary School
Authors: Emm-Collison Lydia G. , Lewis Sarah , Reid Thomas , Matthews Joe , Sebire Simon J. , Thompson Janice L. , Salway Ruth , Jago Russell
Published: August 2019

Physical activity levels decline, and screen-viewing behaviours increase during childhood and adolescence. The transition to secondary school appears to coincide with a sharp decline in physical activity. Parents have the potential to influence their child’s behaviours, yet little is known about their expectations for their child’s physical activity and screen-viewing during this transition. This paper explores parents’ expectations for their children’s physical activity and screen-viewing as they transition from primary to secondary school, and their proposed strategies for managing these behaviours during this time. Forty-two parents of children aged 10–11 years participated in a semi-structured telephone interviews in July 2017 or March 2018. The interview data were analysed via inductive and deductive content analysis to explore parents’ perceptions of physical activity and screen-viewing during the transition, the reasons for their perceptions, and the strategies they intended to implement to help their child balance their behaviours. Most parents expected both physical activity and screen-viewing to increase during this transition. There were several individuals, social and school-level factors influencing these expectations. Overall, parents felt that helping their child balance their activity levels, screen-viewing and homework would be challenging.
Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties
Authors: Ren Yaqi , Wang Chunlan , Xu Jiakun , Wang Shuaiyu
Published: August 2019

Cafestol and kahweol are natural diterpenes extracted from coffee beans. In addition to the effect of raising serum lipid, in vitro and in vivo experimental results have revealed that the two diterpenes demonstrate multiple potential pharmacological actions such as anti-inflammation, hepatoprotective, anti-cancer, anti-diabetic, and anti-osteoclastogenesis activities. The most relevant mechanisms involved are down-regulating inflammation mediators, increasing glutathione (GSH), inducing apoptosis of tumor cells and anti-angiogenesis. Cafestol and kahweol show similar biological activities but not exactly the same, which might due to the presence of one conjugated double bond on the furan ring of the latter. This review aims to summarize the pharmacological properties and the underlying mechanisms of cafestol-type diterpenoids, which show their potential as functional food and multi-target alternative medicine.
Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis
Authors: Wójcik Piotr , Biernacki Michał , Wroński Adam , Łuczaj Wojciech , Waeg Georg , Žarković Neven , Skrzydlewska Elżbieta
Published: August 2019

The aim of this study was to investigate possible stress-associated disturbances in lipid metabolism in mononuclear cells, mainly lymphocytes of patients with psoriasis vulgaris (Ps, n = 32) or with psoriatic arthritis (PsA, n = 16) in respect to the healthy volunteers (n = 16). The results showed disturbances in lipid metabolism of psoriatic patients reflected by different phospholipid profiles. The levels of non-enzymatic lipid metabolites associated with oxidative stress 8-isoprostaglandin F2α (8-isoPGF2α) and free 4-hydroxynonenal (4-HNE) were higher in PsA, although levels of 4-HNE-His adducts were higher in Ps. In the case of the enzymatic metabolism of lipids, enhanced levels of endocannabinoids were observed in both forms of psoriasis, while higher expression of their receptors and activities of phospholipases were detected only in Ps. Moreover, cyclooxygenase-1 (COX-1) activity was enhanced only in Ps, but cyclooxygenase-2 (COX-2) was enhanced both in Ps and PsA, generating higher levels of eicosanoids: prostaglandin E1 (PGE1), leukotriene B4 (LTB4), 13-hydroxyoctadecadienoic acid (13HODE), thromboxane B2 (TXB2). Surprisingly, some of major eicosanoids 15-d-PGJ2 (15-deoxy-Δ12,14-prostaglandin J2), 15-hydroxyeicosatetraenoic acid (15-HETE) were elevated in Ps and reduced in PsA. The results of our study revealed changes in lipid metabolism with enhancement of immune system-modulating mediators in psoriatic mononuclear cells. Evaluating further differential stress responses in Ps and PsA affecting lipid metabolism and immunity might be useful to improve the prevention and therapeutic treatments of psoriasis.
Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials
Authors: Avallone Rossella , Vitale Giovanni , Bertolotti Marco
Published: August 2019

A nutritional approach could be a promising strategy to prevent or slow the progression of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, since there is no effective therapy for these diseases so far. The beneficial effects of omega-3 fatty acids are now well established by a plethora of studies through their involvement in multiple biochemical functions, including synthesis of anti-inflammatory mediators, cell membrane fluidity, intracellular signaling, and gene expression. This systematic review will consider epidemiological studies and clinical trials that assessed the impact of supplementation or dietary intake of omega-3 polyunsaturated fatty acids on neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases. Indeed, treatment with omega-3 fatty acids, being safe and well tolerated, represents a valuable and biologically plausible tool in the management of neurodegenerative diseases in their early stages.
Oxidative Stress: Role and Response of Short Guanine Tracts at Genomic Locations
Authors: Singh Anju , Kukreti Ritushree , Saso Luciano , Kukreti Shrikant
Published: August 2019

Over the decades, oxidative stress has emerged as a major concern to biological researchers. It is involved in the pathogenesis of various lifestyle-related diseases such as hypertension, diabetes, atherosclerosis, and neurodegenerative diseases. The connection between oxidative stress and telomere shortening via oxidative guanine lesion is well documented. Telomeres are confined to guanine rich ends of chromosomes. Owing to its self-association properties, it adopts G-quadruplex structures and hampers the overexpression of telomerase in the cancer cells. Guanine, being the most oxidation prone nucleobase, when structured in G-quadruplex entity, is found to respond peculiarly towards oxidative stress. Interestingly, this non-Watson–Crick structural feature exists abundantly in promoters of various oncogenes, exons and other genomic locations. The involvement of G-quadruplex architecture in oncogene promoters is well recognized in gene regulation processes. Development of small molecules aimed to target G-quadruplex structures, have found to alter the overexpression of oncogenes. The interaction may lead to the obstruction of diseased cell having elevated level of reactive oxygen species (ROS). Thus, presence of short guanine tracts (Gn) forming G-quadruplexes suggests its critical role in oxidative genome damage. Present review is a modest attempt to gain insight on the association of oxidative stress and G-quadruplexes, in various biological processes.
Water-Soluble Fullerenol C60(OH)36 toward Effective Anti-Air Pollution Induced by Urban Particulate Matter in HaCaT Cell
Authors: Lee Chiang-Wen , Chi Miao-Ching , Peng Kuo-Ti , Chiang Yao-Chang , Hsu Lee-Fen , Yan Yi-Ling , Li Hsing-Yen , Chen Ming-Chun , Lee I-Ta , Lai Chian-Hui
Published: August 2019

Particulate matter (PM), a widespread air pollutant, consists of a complex mixture of solid and liquid particles suspended in air. Many diseases have been linked to PM exposure, which induces an imbalance in reactive oxygen species (ROS) generated in cells, and might result in skin diseases (such as aging and atopic dermatitis). New techniques involving nanomedicine and nano-delivery systems are being rapidly developed in the medicinal field. Fullerene, a kind of nanomaterial, acts as a super radical scavenger. Lower water solubility levels limit the bio-applications of fullerene. Hence, to improve the water solubility of fullerene, while retaining its radical scavenger functions, a fullerene derivative, fullerenol C60(OH)36, was synthesized, to examine its biofunctions in PM-exposed human keratinocyte (HaCaT) cells. The PM-induced increase in ROS levels and expression of phosphorylated mitogen-activated protein kinase and Akt could be inhibited via fullerenol pre-treatment. Furthermore, the expression of inflammation-related proteins, cyclooxygenase-2, heme oxygenase-1, and prostaglandin E2 was also suppressed. Fullerenol could preserve the impaired state of skin barrier proteins (filaggrin, involucrin, repetin, and loricrin), which was attributable to PM exposure. These results suggest that fullerenol could act against PM-induced cytotoxicity via ROS scavenging and anti-inflammatory mechanisms, and the maintenance of expression of barrier proteins, and is a potential candidate compound for the treatment of skin diseases.
The Evaluation of Response to Immunotherapy in Metastatic Renal Cell Carcinoma: Open Challenges in the Clinical Practice
Authors: Raimondi Alessandra , Randon Giovanni , Sepe Pierangela , Claps Melanie , Verzoni Elena , de Braud Filippo , Procopio Giuseppe
Published: August 2019

Immunotherapy has changed the therapeutic scenario of metastatic renal cell carcinoma (mRCC), however the evaluation of disease response to immune-checkpoint inhibitors is still an open challenge. Response evaluation criteria in solid tumors (RECIST) 1.1 criteria are the cornerstone of response assessment to anti-neoplastic treatments, but the use of anti-programmed death receptor 1 (PD1) and other immunotherapeutic agents has shown atypical patterns of response such as pseudoprogression. Therefore, immune-modified criteria have been developed in order to more accurately categorize the disease response, even though their use in the everyday clinical practice is still limited. In this review we summarize the available evidence on this topic, with particular focus on the application of immune-modified criteria in the setting of mRCC.
Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats
Authors: Bukosza Eva , Kaucsár Tamás , Godó Mária , Lajtár Enikő , Tod Pál , Koncsos Gábor , Varga Zoltán , Baranyai Tamás , Tu Nguyen Minh , Schachner Helga , Sőti Csaba , Ferdinandy Péter , Giricz Zoltán , Szénási Gábor , Hamar Péter
Published: August 2019

Feeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired glucose and insulin tolerance, and caused cardiac hypertrophy and mild diastolic dysfunction as published before by Koncsos et al. in 2016. Here we aimed to explore the renal consequences in the same groups of rats. Male Long-Evans rats were fed normal chow (CON; n = 9) or HFD containing 40% lard and were administered STZ at 20 mg/kg (i.p.) at week four (prediabetic rats, PRED, n = 9). At week 21 blood and urine samples were taken and kidney and liver samples were collected for histology, immunohistochemistry and for analysis of gene expression. HFD and STZ increased body weight and visceral adiposity and plasma leptin concentration. Despite hyperleptinemia, plasma C-reactive protein concentration decreased in PRED rats. Immunohistochemistry revealed elevated collagen IV protein expression in the glomeruli, and Lcn2 mRNA expression increased, while Il-1β mRNA expression decreased in both the renal cortex and medulla in PRED vs. CON rats. Kidney histology, urinary protein excretion, plasma creatinine, glomerular Feret diameter, desmin protein expression, and cortical and medullary mRNA expression of TGF-β1, Nrf2, and PPARγ were similar in CON and PRED rats. Reduced AMPKα phosphorylation of the autophagy regulator Akt was the first sign of liver damage, while plasma lipid and liver enzyme concentrations were similar. In conclusion, glomerular collagen deposition and increased lipocalin-2 expression were the early signs of kidney injury, while most biomarkers of inflammation, oxidative stress and fibrosis were negative in the kidneys of obese, prediabetic rats with mild heart and liver injury.
Validating UAS-Based Photogrammetry with Traditional Topographic Methods for Surveying Dune Ecosystems in the Spanish Mediterranean Coast
Authors: Bañón Luis , Pagán José Ignacio , López Isabel , Banon Carlos , Aragonés Luis
Published: August 2019

In the past few years, unmanned aerial systems (UAS) have achieved great popularity for civil uses. One of the present main uses of these devices is low-cost aerial photogrammetry, being especially useful in coastal environments. In this work, a high-resolution 3D model of a beach section in Guardamar del Segura (Spain) has been produced by employing a low maximum takeoff mass (MTOM) UAS, in combination with the use of structure-from-motion (SfM) techniques. An unprecedented extensive global navigation satellite system (GNSS) survey was simultaneously carried out to statistically validate the model by employing 1238 control points for that purpose. The results show good accuracy, obtaining a vertical root mean square error (RMSE) mean value of 0.121 m and a high point density, close to 30 pt/m2, with similar or even higher quality than most coastal surveys performed with classical techniques. UAS technology permits the acquisition of topographic data with low time-consuming surveys at a high temporal frequency. Coastal managers can implement this methodology into their workflow to study the evolution of complex, highly anthropized dune-beach systems such as the one presented in this study, obtaining more accurate surveys at lower costs.
Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds
Authors: Miceli Marisa H.
Published: August 2019

Central nervous system infections due to Aspergillus spp and other hyaline molds such as Fusarium and Scedosporium spp are rare but fatal conditions. Invasion of the central nervous system (CNS) tends to occur as a result of hematogenous dissemination among immunocompromised patients, and by local extension or direct inoculation secondary to trauma in immunocompetent hosts. Efforts should be directed to confirm the diagnosis by image-guided stereotactic brain biopsy when feasible. Non-culture methods could be useful to support the diagnosis, but they have not been validated to be performed in cerebral spinal fluid. Treatment of these infections is challenging given the variable susceptibility profile of these pathogens and the penetration of antifungal agents into the brain.
Performance Evaluation of Vegetable Oil-Based Nano-Cutting Fluids in Environmentally Friendly Machining of Inconel-800 Alloy
Authors: Gupta Munish Kumar , Jamil Muhammad , Wang Xiaojuan , Song Qinghua , Liu Zhanqiang , Mia Mozammel , Hegab Hussein , Khan Aqib Mashood , Collado Alberto Garcia , Pruncu Catalin Iulian , Imran G.M. Shah
Published: August 2019

Recently, the application of nano-cutting fluids has gained much attention in the machining of nickel-based super alloys due their good lubricating/cooling properties including thermal conductivity, viscosity, and tribological characteristics. In this study, a set of turning experiments on new nickel-based alloy i.e., Inconel-800 alloy, was performed to explore the characteristics of different nano-cutting fluids (aluminum oxide (Al2O3), molybdenum disulfide (MoS2), and graphite) under minimum quantity lubrication (MQL) conditions. The performance of each nano-cutting fluid was deliberated in terms of machining characteristics such as surface roughness, cutting forces, and tool wear. Further, the data generated through experiments were statistically examined through Box Cox transformation, normal probability plots, and analysis of variance (ANOVA) tests. Then, an in-depth analysis of each process parameter was conducted through line plots and the results were compared with the existing literature. In the end, the composite desirability approach (CDA) was successfully implemented to determine the ideal machining parameters under different nano-cutting cooling conditions. The results demonstrate that the MoS2 and graphite-based nanofluids give promising results at high cutting speed values, but the overall performance of graphite-based nanofluids is better in terms of good lubrication and cooling properties. It is worth mentioning that the presence of small quantities of graphite in vegetable oil significantly improves the machining characteristics of Inconel-800 alloy as compared with the two other nanofluids.
Understanding Dephosphorization in Basic Oxygen Furnaces (BOFs) Using Data Driven Modeling Techniques
Authors: Barui Sandip , Mukherjee Sankha , Srivastava Amiy , Chattopadhyay Kinnor
Published: August 2019

Owing to the continuous deterioration in the quality of iron ore and scrap, there is an increasing focus on improving the Basic Oxygen Furnace (BOF) process to utilize lower grade input materials. The present paper discusses dephosphorization in BOF steelmaking from a data science perspective, which thus enables steelmakers to produce medium and low phosphorus steel grades. In the present study, data from two steel mills (Plant I and Plant II) were collected and various statistical methods were employed to analyze the data. While most operators in steel plants use spreadsheet-based techniques and linear regression to analyze data, this paper discusses on the suitability of selecting various statistical methods, and benchmarking tests to analyze such dephosphorization data sets. The data contains a wide range of operating conditions, both low and high phosphorus input loads, different slag basicity’s, different slag chemistries, and different end point temperatures, etc. The predicted phosphorus partition from various statistical models is compared against plant data and verified against previously published research.
The Experiences of People Living with Peripheral Neuropathy in Kuwait—A Process Map of the Patient Journey
Authors: Alkandari Maryam , Ryan Kath , Hollywood Amelia
Published: August 2019

Peripheral neuropathy is a neurological disease characterised by pain, numbness, tingling, swelling or muscle weakness due to nerve damage, caused by multiple factors such as trauma, infections and metabolic diseases such as diabetes. In Kuwait 54% of the diabetic population, has peripheral neuropathy. In this exploratory, qualitative study conducted in Kuwait, 25 subjects with peripheral neuropathy took part in one-on-one, semi-structured interviews lasting 45–60 min. Interviews were transcribed, translated into English and coded using NVivo 12. Four individual patient journeys were mapped out in detail, then compared and condensed into a single process map. The remaining 21 interviews were then reviewed to ensure the final map represented all patient journeys. Participants reported similar healthcare pathways for their peripheral neuropathy and faced various difficulties including lack of psychological support, administrative issues (long waiting referral periods, loss of medical documents, shortage of specialists and lack of centralized electronic medical records) and inadequate medical care (shortage of new treatments and deficient follow-ups). Mapping the patient journey in Kuwait showed similar pharmacological treatment to UK guidelines, except that some medicines were unavailable. The map also indicated the need for an integrated referral approach, the use of technology for electronic medical recording and report transmission, alongside education on self-management, coping mechanisms and treatment options for people living with peripheral neuropathy.
The Evolution of the KANADI Gene Family and Leaf Development in Lycophytes and Ferns
Authors: Zumajo-Cardona Cecilia , Vasco Alejandra , Ambrose Barbara A.
Published: August 2019

Leaves constitute the main photosynthetic plant organ and even though their importance is not debated, the origin and development of leaves still is. The leaf developmental network has been elucidated for angiosperms, from genes controlling leaf initiation, to leaf polarity and shape. There are four KANADI (KAN) paralogs in Arabidopsis thaliana needed for organ polarity with KAN1 and KAN2 specifying abaxial leaf identity. Yet, studies of this gene lineage outside angiosperms are required to better understand the evolutionary patterns of leaf development and the role of KAN homologs. We studied the evolution of KAN genes across vascular plants and their expression by in situ hybridization in the fern, Equisetum hyemale and the lycophyte Selaginella moellendorffii. Our results show that the expression of KAN genes in leaves is similar between ferns and angiosperms. However, the expression patterns observed in the lycophyte S. moellendorffii are significantly different compared to all other vascular plants, suggesting that the KAN function in leaf polarity is likely only conserved across ferns, gymnosperms, and angiosperms. This study indicates that mechanisms for leaf development are different in lycophytes compared to other vascular plants.
Brazilian Validation of Centrality of Religiosity Scale (CRS-10BR and CRS-5BR)
Authors: Esperandio Mary Rute Gomes , August Hartmut , Viacava Juan José Camou , Huber Stefan , Fernandes Márcio Luiz
Published: August 2019

The centrality of religiosity scale (CRS), available in three versions (with 5, 10 and 15 items), is a measuring instrument that identifies the central importance of religiosity in the psychological construction and in the behavior of an individual. According to the literature, five components together express the centrality of religion in life: Public practice, private practice, ideological, intellectual, and religious experience. These components are the ground on which religious constructs are formed and activated. For the validation of the scale in the Brazilian cultural context, two versions were tested (CRS-10BR and CRS-5BR) with data collected from a general population (N = 687). Exploratory Factor Analysis (N = 334) resulted in a five-factor solution congruent to CRS-10BR. Confirmatory Factor Analysis (N = 353) demonstrated that a five-factor solution (Intellect, Ideology, Private Practice, Public Practice and Religious Experience) indicated better fit indexes than the single-factor solution of five items (CRS-5BR). Thus, CRS-10BR is recommended to capture CRS full construct. However, the CRS-5BR version can be considered suitable for use in the Brazilian population when the context is demanding simpler and faster data collection.
PLANHEAT’s Satellite-Derived Heating and Cooling Degrees Dataset for Energy Demand Mapping and Planning
Authors: Sismanidis Panagiotis , Keramitsoglou Iphigenia , Barberis Stefano , Dorotić Hrvoje , Bechtel Benjamin , Kiranoudis Chris T.
Published: August 2019

The urban heat island (UHI) effect influences the heating and cooling (H&C) energy demand of buildings and should be taken into account in H&C energy demand simulations. To provide information about this effect, the PLANHEAT integrated tool—which is a GIS-based, open-source software tool for selecting, simulating and comparing alternative low-carbon and economically sustainable H&C scenarios—includes a dataset of 1 × 1 km hourly heating and cooling degrees (HD and CD, respectively). HD and CD are energy demand proxies that are defined as the deviation of the outdoor surface air temperature from a base temperature, above or below which a building is assumed to need heating or cooling, respectively. PLANHEAT’s HD and CD are calculated from a dataset of gridded surface air temperatures that have been derived using satellite thermal data from Meteosat-10 Spinning Enhanced Visible and Near-Infrared Imager (SEVIRI). This article describes the method for producing this dataset and presents the results for Antwerp (Belgium), which is one of the three validation cities of PLANHEAT. The results demonstrate the spatial and temporal information of PLANHEAT’s HD and CD dataset, while the accuracy assessment reveals that they agree well with reference values retrieved from in situ surface air temperatures. This dataset is an example of application-oriented research that provides location-specific results with practical utility.
An Affordable Method for Evaluation of Ataxic Disorders Based on Electrooculography
Authors: López Alberto , Ferrero Francisco , Postolache Octavian
Published: August 2019

Ataxias are a group of neurodegenerative disorders characterized by cerebellar dysfunction that cause irregularities in the rate, rhythm, amplitude, and force of voluntary movements. The electrooculogram (EOG) may provide clues about ataxic disorders because most of these patients have difficulty with visual tracking and fixing their gaze. Using electrodes, EOG records the biopotentials generated by eye movements. In this paper, three surface electrodes are placed around the eye socket, and the biopotentials generated by eye movements are acquired using a commercial bioamplifier device. Next, the signals are sent to the computer to be digitally processed to extract the rate of saccades as well as the delay and deviation of the gaze in response to a stimulus. These features are analysed in a novel software application designed to help physicians in evaluating ataxia. After applying several tests to both healthy and ataxia-affected patients, differences in EOG results were found. The evaluation of the reliability of the designed software application is made according to three metrics: sensitivity, specificity, and accuracy. The results indicate the proposed system’s viability as an affordable method for evaluation of ataxic disorders.
Development of Miniaturized Water Quality Monitoring System Using Wireless Communication
Authors: Yu Hsing-Cheng , Tsai Ming-Yang , Tsai Yuan-Chih , You Jhih-Jyun , Cheng Chun-Lin , Wang Jung-How , Li Szu-Ju
Published: August 2019

Recently, environmental pollution resulting from industrial waste has been emerging in an endless stream. The industrial waste contains chemical materials, heavy metal ions, and other toxic materials. Once the industrial waste is discharged without standards, it might lead to water or environmental pollution. Hence, it has become more important to provide evidence-based water quality monitoring. The use of a multifunctional miniaturized water quality monitoring system (WQMS), that contains continuous monitoring, water quality monitoring, and wireless communication applications, simultaneously, is infrequent. Thus, electrodes integrated with polydimethylsiloxane flow channels were presented in this study to be a compound sensor, and the sensor can be adopted concurrently to measure temperature, pH, electrical conductivity, and copper ion concentration, whose sensitivities are determined as 0.0193 °C/mV, −0.0642 pH/mV, 1.1008 mS/V·cm (from 0 mS/cm to 2 mS/cm) and 1.1975 mS/V·cm (from 2 mS/cm to 5.07 mS/cm), and 0.0111 ppm/mV, respectively. A LoRa shield connected into the system could provide support as a node of long range wide area network (LoRaWAN) for wireless communication application. As mentioned above, the sensors, LoRa, and circuit have been integrated in this study to a continuous monitoring system, WQMS. The advantages of the multifunctional miniaturized WQMS are low cost, small size, easy maintenance, continuous sampling and long-term monitoring for many days. Every tested period is 180 min, and the measured rate is 5 times per 20 min. The feedback signals of the miniaturized WQMS and measured values of the instrument were obtained to compare the difference. In the measured results at three different place-to-place locations the errors of electrical conductivity are 0.051 mS/cm, 0.106 mS/cm, and 0.092 mS/cm, respectively. The errors of pH are 0.68, 0.87, and 0.56, respectively. The errors of temperature are 0.311 °C, 0.252 °C, and 0.304 °C, respectively. The errors of copper ion concentration are 0.051 ppm, 0.058 ppm, 0.050 ppm, respectively.
Opportunities, Challenges, and Prospects in Electrochemical Biosensing of Circulating Tumor DNA and Its Specific Features
Authors: Campuzano Susana , Serafín Verónica , Gamella Maria , Pedrero María , Yáñez-Sedeño Paloma , Pingarrón José M.
Published: August 2019

Nowadays, analyzing circulating tumor DNA (ctDNA), a very small part of circulating free DNA (cfDNA) carried by blood, is considered to be an interesting alternative to conventional single-site tumor tissue biopsies, both to assess tumor burden and provide a more comprehensive snapshot of the time-related and spatial heterogeneity of cancer genetic/epigenetic scenery. The determination of ctDNA and/or mapping its characteristic features, including tumor-specific mutations, chromosomal aberrations, microsatellite alterations, and epigenetic changes, are minimally invasive, powerful and credible biomarkers for early diagnosis, follow-up, prediction of therapy response/resistance, relapse monitoring, and tracking the rise of new mutant subclones, leading to improved cancer outcomes This review provides an outline of advances published in the last five years in electrochemical biosensing of ctDNA and surrogate markers. It emphasizes those strategies that have been successfully applied to real clinical samples. It highlights the unique opportunities they offer to shift the focus of cancer patient management methods from actual decision making, based on clinic-pathological features, to biomarker-driven treatment strategies, based on genotypes and customized targeted therapies. Also highlighted are the unmet hurdles and future key points to guide these devices in the development of liquid biopsy cornerstone tools in routine clinical practice for the diagnosis, prognosis, and therapy response monitoring in cancer patients.
An Empirical Study Comparing Unobtrusive Physiological Sensors for Stress Detection in Computer Work
Authors: Akbar Fatema , Mark Gloria , Pavlidis Ioannis , Gutierrez-Osuna Ricardo
Published: August 2019

Several unobtrusive sensors have been tested in studies to capture physiological reactions to stress in workplace settings. Lab studies tend to focus on assessing sensors during a specific computer task, while in situ studies tend to offer a generalized view of sensors’ efficacy for workplace stress monitoring, without discriminating different tasks. Given the variation in workplace computer activities, this study investigates the efficacy of unobtrusive sensors for stress measurement across a variety of tasks. We present a comparison of five physiological measurements obtained in a lab experiment, where participants completed six different computer tasks, while we measured their stress levels using a chest-band (ECG, respiration), a wristband (PPG and EDA), and an emerging thermal imaging method (perinasal perspiration). We found that thermal imaging can detect increased stress for most participants across all tasks, while wrist and chest sensors were less generalizable across tasks and participants. We summarize the costs and benefits of each sensor stream, and show how some computer use scenarios present usability and reliability challenges for stress monitoring with certain physiological sensors. We provide recommendations for researchers and system builders for measuring stress with physiological sensors during workplace computer use.
The Emotional Risks of Turning Stories into Data: An Exploration of the Experiences of Qualitative Researchers Working on Sensitive Topics
Authors: Mallon Sharon , Elliott Iris
Published: August 2019

A great deal of research has been undertaken into areas involving sensitive topics. In spite of longstanding acceptance that such research can be emotionally risky for participants, interest in the impact of this work on the researcher has only relatively recently become a topic of concern. This paper reports on a roundtable convened with qualitative researchers working in sensitive research areas. The article explores their views in relation to the emotional risks they encountered in relation to their work. A grounded theory, thematic analysis was used to analyse the data and comparisons are made between researcher experiences and those highlighted by earlier studies. We illuminate how researchers described personal concerns about the emotional risks, before focusing on how the researcher’s sense of professionalism contributed to, or protected against, these emotional risks and emotions. This paper also discusses the faltering nature of the support provided to these researchers and the challenges created by the need they felt to create impactful research. The authors conclude by arguing that current support and guidance provided to researchers working in sensitive areas fails to address the complexity of the emotional reaction of the researcher. We call for the development of specialised training and improved use of theoretical concepts such as emotion work, to guide those undertaking this challenging work.
Community-Based Tourism and Sustainable Development of Rural Regions in Kenya; Perceptions of the Citizenry
Authors: Juma Leanard Otwori , Khademi-Vidra Aniko
Published: August 2019

Community-Based Tourism (CBT) has been pushed as one of the strategies for poverty alleviation and it might enhance the sustainability of marginalized regions and communities. However, tourism has also been argued to carry seeds for its own destruction and therefore presents a great dilemma and developmental paradox. This research sought to establish perceptions of the citizenry towards community-based tourism as a sustainable development strategy for rural regions in Kenya. The study focused on the awareness levels of CBT, and perceived contributions of CBT to the socio-economic and physical sustainability of rural regions in Kenya. A descriptive research design was adopted with a sample of 395 respondents. Data collected were collated and analyzed using SPSS 25 and Nvivo 12. Findings revealed that agriculture and other economic activities can be integrated with tourism and hospitality to deliver sustainable development in rural regions given the vast resources and attributes ideal for CBT. The majority of the respondents were noted to have a fair understanding of what CBT entails and thus calling for more capacity building, training and appropriate technical support to unlock the full potential of CBT as a sustainable development strategy. Overall results showed favorable perceptions towards CBT as a tool that can contribute to the sustainability of the socio-economic and physical environments in Kenya’s rural region.
Conformity Consumption Behavior and FoMO
Authors: Kang Inwon , Cui Haixin , Son Jeyoung
Published: August 2019

Culturally associated brands that reflect the cultural backgrounds of other countries have been extensively studied, but research on the conformity consumption of culturally associated brands in specific countries has rarely been conducted. This study focuses on the fear of missing out (FoMO) phenomenon as a tool for explaining consumers’ conformity consumption and examines what causes it. Although the FoMO concept is primarily used in the online field, it is considered to be a very suitable tool for explaining offline consumption behavior as well. This study will be useful for establishing long-term and sustainable strategies by firms through matured discussions on conformity consumption.
Perceived Serviceability of Outplacement Programs as a Part of Sustainable Human Resource Management
Authors: Gyurák Babeľová Zdenka , Stareček Augustín , Cagáňová Dagmar , Fero Martin , Čambál Miloš
Published: August 2019

Work and employment are important elements of every working person’s life. If an employee loses his or her job, he or she loses an important and determining part of his or her life. To reduce the negative effects that affect the quality of an employee’s life, outplacement programs were established as a part of sustainable human resource management. Sustainable human resource management emphasises the importance of employee care. Outplacement, for its part, includes support for employees at their last stage in the organization. The main aims of the paper are to present the research results focused on the perceived usefulness of outplacement programs for dismissed employees, to analyse the relationships between the emotions felt by redundancies and other employees as well as the comparison of differences in emotions felt by different generations of dismissed employees. A valid collection tool (research questionnaire) was developed for research purposes and distributed to employees of industrial enterprises in the Slovak Republic. Overall, the research set was composed of n = 692 employees from different generational groups. The research results proved the existence of a relationships between the emotions felt by redundancies and other employees and differences in emotions felt by employees from different generational groups.
Point Cloud-Oriented Inspection of Old Street’s Sustainable Transformation from the Ceramic Industry to Cultural Tourism: A Case Study of Yingge, a Ceramic Town in Taiwan
Authors: Shih Naai-Jung , Hsu Wen-Tse , Diao Pei-Huang
Published: August 2019

Yingge, a ceramic-producing town in Northern Taiwan, has experienced three development stages in the 50 years since 1970. The town’s fabric and the second contour evolved through the transformation of its former manufacturing industry into cultural tourism on Old Street. This process of evolution is evidenced through chronological changes of overlaid sections, skylines, and horizontal sections along Old Street since 1970. The street fabric has been shaped by its historical background, government planning strategies, commercial activities, cultural identity, and living patterns. Three-dimensional (3D) scans supported our analysis by capturing and segmenting the vocabularies and overlaid sections with special characteristics and changes. Commercial spaces and open street spaces were found to be mutually influential. A flexible and sometimes hidden spatial structure of fabric was elucidated. Yingge has become a large-scale shopping mall and important window into cultural tourism, with its fabric and contours redeveloped to be consistent with the identity of nearby cities. 3D scanning data were combined with documentation and maps to create a referable connection between reality and chronological data. An augmented reality (AR) application was used to simplify the inspection process through a productive connection between as-built scans and user interactions.