bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comprehensive, Multi-Modal Strategy to Mitigate Alzheimer’s Disease Risk Factors Improves Aspects of Metabolism and Offsets Cognitive Decline in Individuals with Cognitive Impairment
Authors: Schechter Ginger , Azad Gajendra Kumar , Rao Rammohan , McKeany Allison , Matulaitis Matthew , Kalos Denise M. , Kennedy Brian K.
Published: June 2020

Background:

Alzheimer’s disease (AD) is a chronic condition that progresses over time. While several therapeutic approaches have been developed, none have substantially altered disease progression. One explanation is that the disease is multi factorial.

Objective:

Using the Affirmativ Health Personal Therapeutic Program (PTPr), we sought to determine whether a comprehensive and personalized program could improve cognitive and metabolic function in individuals diagnosed with subjective cognitive impairment, mild cognitive impairment, and early stage AD.

Methods:

35 individuals submitted blood samples and Montreal Cognitive Assessment (MoCA) scores, and answered intake questions. Individuals and caregivers participated in a four-day immersion program, which included Personal Therapeutic Plans (PTP), consultations with clinical practitioners, and explanations of the PTPr and PTP. Participants had follow-up by telemonitoring, with repeat blood sample analysis, updates regarding lifestyle choices, current medications and supplements, and MoCA testing at least once between 3 and 12 months after the PTPr.

Results:

By comparing baseline to follow-up testing, we determined several risk factor scores, including blood glucose and insulin levels, and levels of vitamins B12, D3, and E, improved either in the entire participant pool or specifically in individuals with measures outside the normal range for specific factors. MoCA scores were stabilized in the entire participant pool and significantly improved in individuals scoring 24 or less at baseline.

Conclusion:

Our findings provide evidence that a comprehensive and personalized approach designed to mitigate AD risk factors can improve risk factor scores and stabilize cognitive function, warranting more extensive and placebo-controlled clinical studies.
CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma
Authors: Wu Jun
Published: June 2020

BACKGROUND: The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is the protein product of at least one splice variant of each gene contained a Marvel (MAL and related proteins for vesicle trafficking and membrane link) domain, involved in a variety of cellular processes and the pathogenesis of diseases, including tumorigenesis. However, the diverse expression patterns and prognostic values of eight CMTMs have yet to be elucidated. OBJECTIVE: We analyzed the expressions and impacts on survival of different CMTM factors in BC patients to determine their potential diagnosis and prognosis values in BC. METHODS: In the current study, we examined the transcriptional and survival data of CMTMs in patients with breast carcinoma (BC) from ONCOMINE, GEPIA, Kaplan-Meier Plotter, and cBioPortal databases. RESULTS: It was found that CMTM5/7 were down-regulated, whereas CMTM1/6 were up-regulated in BC patients compared with the normal tissues. In survival analyses through the Kaplan-Meier plotter database, increased mRNA expressions of CMTM5/6/7 and decreased mRNA expression of CMTM4 were associated with better relapse-free survival (RFS) of BC patients. CONCLUSIONS: These data provided CMTM5/7 as new biomarker and prognostic factors in BC.
Anti-Relapse effects of donor natural killer cells and IL-2 gene modification on allogeneic hematopoietic stem cell transplantation in acute leukemia
Authors: Xue Zhanxia , Gao Yongshan , Wu Xueliang
Published: June 2020

BACKGROUND: Patients with acute leukemia (AL) refractory to induction or reinduction chemotherapy show poor prognoses if they do not undergo allogeneic hematopoietic stem-cell transplantation (AHSCT). The present study aims to investigate whether donor natural killer (NK) cells and interleukin-2 (IL-2) gene modification exert anti-relapse effects on AHSCT after establishing a mouse model of AL. METHODS: C57BL/6 (H-2b) mice were selected as donor mice to obtain NK cells and hematopoietic stem cells, while BALB/c (H-2d) mice were selected as the recipient mice for AHSCT. The AHSCT-treated mice were then injected with the donor NK cells, recombinant adenovirus expressing IL-2 (AdIL-2), or the NK cells infected by AdIL-2. Flow cytometry was performed to detect the cell transplantation rate, immune cell number, and cell immunogenicity. Enzyme-linked immunosorbent assay (ELISA) was employed to quantify the secretion of IL-2 in spleen cells, and the level of peripheral blood factors, including interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), IL-35, transforming growth factor β (TGF-β), and IL-10. RESULTS: In our experiments, promotional effects of NK cells and AdIL-2 were found on cell transplantation rate, immune reconstitution ability, cell immunogenicity, IL-2 secretion, as well as increased peripheral blood factor levels in the recipient mice treated with AHSCT, with improved pathological changes observed. Moreover, the aforementioned changes were further promoted in the AHSCT-treated recipient mice injected with the AdIL-2-infected NK cells. CONCLUSIONS: These results uncover that the donor NK cells and IL-2 gene modification could inhibit the relapse of AL mice underwent AHSCT, hereby providing a new target for leukemia treatment.
Empirical research on the role of internal social capital upon the innovation performance of cooperative firms
Authors: David Kashosi Gad , Yang Wu , Bianca Epede Mesumbe , Getele Gutama Kusse
Published: June 2020

BACKGROUND: Internal social capital in the cooperative firms has emerged in recent years as an important concept for improving innovation performance. OBJECTIVE: We explore whether the cohabitation of the different interacting social groups, namely cooperative members, and non-cooperative members, will generate disparate impacts on the circumstance for enhanced innovation. METHODOLOGY: A sample of 180 cooperative firms in Ethiopia, with two respondents per firm, consisting of one adherent and one non-adherent member, we reflected on the theory of social capital, and by adopting a relational, cognitive, and structural concept. We conducted Structural Equation Modeling (SEM) through PLS to analyze the importance of each group for innovation performance. RESULTS: Our results suggested that the internal interaction between adherent and non-adherent members of cooperative enterprises positively influences their “innovation performance”. The findings also revealed that non-adherent members were more involved in building innovation than adherent members. CONCLUSIONS: The results provide empirical evidence that internal social factors are essential assets for effective innovation in cooperatives, and established a new line of research within an empirical perspective.
Authentic leadership and employee engagement: The role of employee well-being
Authors: Koon Vui-Yee , Ho Tsu-Sin
Published: June 2020

BACKGROUND/OBJECTIVE: To understand how perceived authentic leadership translates into work engagement, this study hypothesize that perceived authentic leadership facilitates positive conditions of well-being, which in turn predict employee work engagement. This study asserts that each of the three mediating paths comprising life, workplace, and psychological well-being, is expected to mediate the relationship based on the conservation of resources (COR) theory and relational perspective. METHODOLOGY: Data were collected from the two-wave survey of 150 full-time employees and analyzed using the PROCESS macro in SPSS. An additional analysis to identify well-being sentiment was conducted using NodeXL with Twitter data. RESULTS: The results indicated only workplace well-being has a mediational effect between perceived authentic leadership and work engagement. The additional analysis found that workplace well-being is the central tenet of interaction between people in social media. CONCLUSIONS: These findings demonstrate the importance of workplace well-being in promoting work engagement.
Mainstreaming populism through the Twitter practices of politicians and the news media: A case study of the 2016 Brexit referendum debates
Authors: Tong Jingrong , Zuo Landong
Published: June 2020

Over recent years, the Western world has witnessed the (re-)rise of populism, which was marginal compared to the (once-)dominant ideologies of globalisation and European integration. This article examines the role played by the Twitter practices of politicians and the news media in mainstreaming populism through a case study of the 2016 Brexit referendum debates. The communicative freedom of politicians and the extensive attention given to them by users enabled the presenting of populist arguments as a legitimate part of debates about the referendum. The news media paid overwhelming attention to politicians and focused on the issues of immigration and the economy in their tweets, creating the sphere of legitimate controversy where populist arguments appeared in parallel with those supporting globalisation and European integration. In this case, the Twitter practices of British politicians and the news media led to the extensive – but largely uncritical – presence and articulation of populist claims on Twitter. Their strong presence alongside pro-EU and pro-globalisation arguments gave these populist perspectives a central place in the debates on the referendum. The mainstreaming of populism through the Twitter practices of politicians and the news media is inextricably linked with, and thus needs to be understood within, the broader context of rising populism where the (once-)dominant ideologies of globalisation and European integration are in decline.
Assessing the Utility of Language and Voice Biomarkers to Predict Cognitive Impairment in the Framingham Heart Study Cognitive Aging Cohort Data
Authors: Thomas Jason A. , Burkhardt Hannah A. , Chaudhry Safina , Ngo Anthony D. , Sharma Saransh , Zhang Larry , Au Rhoda , Hosseini Ghomi Reza
Published: June 2020

Background:

There is a need for fast, accessible, low-cost, and accurate diagnostic methods for early detection of cognitive decline. Dementia diagnoses are usually made years after symptom onset, missing a window of opportunity for early intervention.

Objective:

To evaluate the use of recorded voice features as proxies for cognitive function by using neuropsychological test measures and existing dementia diagnoses.

Methods:

This study analyzed 170 audio recordings, transcripts, and paired neuropsychological test results from 135 participants selected from the Framingham Heart Study (FHS), which includes 97 recordings of cognitively normal participants and 73 recordings of cognitively impaired participants. Acoustic and linguistic features of the voice samples were correlated with cognitive performance measures to verify their association.

Results:

Language and voice features, when combined with demographic variables, performed with an AUC of 0.942 (95% CI 0.929–0.983) in predicting cognitive status. Features with good predictive power included the acoustic features mean spectral slope in the 500–1500 Hz band, variation in the F2 bandwidth, and variation in the Mel-Frequency Cepstral Coefficient (MFCC) 1; the demographic features employment, education, and age; and the text features of number of words, number of compound words, number of unique nouns, and number of proper names.

Conclusion:

Several linguistic and acoustic biomarkers show correlations and predictive power with regard to neuropsychological testing results and cognitive impairment diagnoses, including dementia. This initial study paves the way for a follow-up comprehensive study incorporating the entire FHS cohort.
National Dementia BioBank: A Strategy for the Diagnosis and Study of Neurodegenerative Diseases in México
Authors: Reyes-Pablo Aldelmo Emmanuel , Campa-Córdoba B. Berenice , Luna-Viramontes Nabil Itzi , Ontiveros-Torres Miguel Ángel , Villanueva-Fierro Ignacio , Bravo-Muñoz Marely , Sáenz-Ibarra Bárbara , Barbosa Oralia , Guadarrama-Ortíz Parménides , Garcés-Ramírez Linda , de la Cruz Fidel , Harrington Charles R. , Martínez-Robles Sandra , González-Ballesteros Erik , Perry George , Pacheco-Herrero Mar , Luna-Muñoz José
Published: June 2020

We recently developed the National Dementia Biobank in México (BioBanco Nacional de Demencias, BND) as a unit for diagnosis, research, and tissue transfer for research purposes. BND is associated with the Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico (UNAM), Mexico. The donation of fluids, brain, and other organs of deceased donors is crucial for understanding the underlying mechanisms of neurodegenerative diseases and for the development of successful treatment. Our laboratory research focuses on 1) analysis of the molecular processing of the proteins involved in those neurodegenerative diseases termed tauopathies and 2) the search for biomarkers for the non-invasive and early diagnosis of Alzheimer’s disease.
Mutation Analysis of the Genes Associated with Parkinson’s Disease in a Finnish Cohort of Early-Onset Dementia
Authors: Luukkainen Laura , Huttula Samuli , Väyrynen Henri , Helisalmi Seppo , Kytövuori Laura , Haapasalo Annakaisa , Hiltunen Mikko , Remes Anne M. , Krüger Johanna
Published: June 2020

Background:

Alzheimer’s disease, frontotemporal lobar degeneration, dementia with Lewy bodies, and Parkinson’s disease (PD) overlap in clinical characteristics, neuropathology, and genetics.

Objective:

The aim of this study was to evaluate the role of pathogenic mutations and rare variants in genes associated with PD among early-onset dementia (EOD) patients.

Methods:

Rare non-synonymous variants (MAF < 0.01) in ten genes ( SNCA, PARK2, PARK7, LRRK2, PINK1, ATP13A2, UCHL1, HTRA2, GBA, and SNCAIP) and low-frequency (MAF < 0.05) GBA variants were screened using a targeted next-generation sequencing panel in a strictly defined cohort of 37 early-onset (age at onset (AAO) <65 years) dementia patients presenting with atypical features (e.g., myoclonia or spasticity), rapidly progressive course of the disease or with a family history of dementia. The identified variations were further screened in a larger cohort of EOD ( n = 279, mean AAO 57, range 36–65) patients.

Results:

No pathogenic mutations were found, but we identified seven possible risk variants for neurodegeneration ( LRRK2 p.Arg793Met, PARK2 p.Ala82Glu, SNCAIP p.Arg240Gln, SNCAIP p.Phe369Leu, GBA p.Asn409Ser, GBA p.Glu365Lys, GBA p.Thr408Met).

Discussion:

Altogether, the frequency of these variants was two times higher in the first selected cohort compared to the whole cohort. This suggests that specific rare variants in the genes associated with PD might play a role also especially in familial EOD.
Towards a Redefinition of Cognitive Frailty
Authors: Mantovani Elisa , Zucchella Chiara , Schena Federico , Romanelli Maria Grazia , Venturelli Massimo , Tamburin Stefano
Published: June 2020

Background:

The progressive aging of the population will dramatically increase the burden of dementia related to Alzheimer’s disease (AD) and other neurodegenerative disorders in the future. Because of the absence of drugs that can modify the neuropathological substrate of AD, research is focusing on the application of preemptive and disease-modifying strategies in the pre-symptomatic period of the disease. In this perspective, the identification of people with cognitive frailty (CF), i.e., those individuals with higher risk of developing dementia, on solid pathophysiological bases and with clear operational clinical criteria is of paramount importance.

Objective/Methods:

This hypothesis paper reviews the current definitions of CF, presents and discusses some of their limitations, and proposes a framework for updating and improving the conceptual and operational definition of the CF construct.

Results:

The potential for reversibility of CF should be supported by the assessment of amyloid, tau, and neuronal damage biomarkers, especially in younger patients. Physical and cognitive components of frailty should be considered as separate entities, instead of part of a single macro-phenotype. CF should not be limited to the geriatric population, because trajectories of amyloid accumulation are supposed to start earlier than 65 years in AD. Operational criteria are needed to standardize assessment of CF.

Conclusion:

Based on the limitations of current CF definitions, we propose a revised one according to a multidimensional subtyping. This new definition might help stratifying CF patients for future trials to explore new lifestyle interventions or disease-modifying pharmacological strategies for AD and dementia.
Fascicle- and Glucose-Specific Deterioration in White Matter Energy Supply in Alzheimer’s Disease
Authors: Roy Maggie , Rheault François , Croteau Etienne , Castellano Christian-Alexandre , Fortier Mélanie , St-Pierre Valérie , Houde Jean-Christophe , Turcotte Éric E. , Bocti Christian , Fulop Tamas , Cunnane Stephen C. , Descoteaux Maxime
Published: June 2020

Background:

White matter energy supply to oligodendrocytes and the axonal compartment is crucial for normal axonal function. Although gray matter glucose hypometabolism is extensively reported in Alzheimer’s disease (AD), glucose and ketones, the brain’s two main fuels, are rarely quantified in white matter in AD.

Objective:

Using a dual-tracer PET method combined with a fascicle-specific diffusion MRI approach, robust to white matter hyper intensities and crossing fibers, we aimed to quantify both glucose and ketone metabolism in specific white matter fascicles associated with mild cognitive impairment (MCI; n = 51) and AD ( n = 13) compared to cognitively healthy age-matched controls (Controls; n = 14).

Methods:

Eight white matter fascicles of the limbic lobe and corpus callosum were extracted and analyzed into fascicle profiles of five sections. Glucose (18F-fluorodeoxyglucose) and ketone (11C-acetoacetate) uptake rates, corrected for partial volume effect, were calculated along each fascicle.

Results:

The only fascicle with significantly lower glucose uptake in AD compared to Controls was the left posterior cingulate segment of the cingulum (–22%; p = 0.016). Non-significantly lower glucose uptake in this fascicle was also observed in MCI. In contrast to glucose, ketone uptake was either unchanged or higher in sections of the fornix and parahippocampal segment of the cingulum in AD.

Conclusion:

To our knowledge, this is the first report of brain fuel uptake calculated along white matter fascicles in humans. Energetic deterioration in white matter in AD appears to be specific to glucose and occurs first in the posterior cingulum.
Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer’s Disease
Authors: Narukawa Masataka , Takahashi Suzuka , Saito Takashi , Saido Takaomi C. , Misaka Takumi
Published: June 2020

Background:

Some studies have reported a decline in taste sensitivities in patients with Alzheimer’s disease. However, the detail remains unknown.

Objective:

We investigated the effect of cognitive impairment on taste sensitivity using an App knock-in mouse model of Alzheimer’s disease.

Methods:

Behavioral assays, a brief access test, and a 48 h two-bottle preference test, to assess taste sensitivities were started from 12 months of age in mice that were confirmed to have impaired cognition.

Results:

In the assays, there was no significant difference in taste sensitivities between wild type and App knock-in mice. Additionally, no apparent difference was observed in the expression of taste markers in their taste bud cells.

Conclusion:

We concluded that cognitive impairment might not greatly affect taste sensitivity.
Air Pollution as Risk Factor for Mental Disorders: In Search for a Possible Link with Alzheimer’s Disease and Schizophrenia
Authors: Attademo Luigi , Bernardini Francesco
Published: June 2020

As a global problem that has increasingly been causing worldwide concern, air pollution poses a significant and serious environmental risk to health. Risks of cardiovascular and respiratory diseases, as well as various types of cancer, have been consistently associated with the exposure to air pollutants. More recently, various studies have also shown that the central nervous system is also attacked by air pollution. Air pollution appears to be strongly associated with a higher risk of cognitive defects, neurodevelopmental (e.g., schizophrenia) and neurodegenerative (e.g., Alzheimer’s disease) disorders. Subjects with schizophrenia, as well as subjects with Alzheimer’s disease, experience a variety of neuropsychological deficits and cognitive impairments. This determines an adverse effect on social and professional functioning, and it contributes to the long-term disease burden. However, no final conclusions have been drawn on the matter of the direct relationship between schizophrenia and Alzheimer’s disease. In recent years, the topic of urbanicity and mental health has become increasingly important. Urban exposure to environmental toxins and pollution is currently described as a reliable risk factor for schizophrenia and other psychoses, and it has been demonstrated more and more how exposure to air pollutants is associated with increased risk of dementia. Pathways by which air pollution can target and damage the brain, leading to an increased risk for developing schizophrenia and Alzheimer’s disease, are multiple and complex. Results from epidemiological studies suggest potential associations, but are still insufficient to confirm causality. Further studies are needed in order to verify this hypothesis. And if confirmed, the clinical implications could be of substantial relevance for both public and mental health.
Association Between the Tumor Marker Carcinoembryonic Antigen and the Risk of Dementia
Authors: van der Willik Kimberly D. , Schagen Sanne B. , Ikram M. Arfan
Published: June 2020

There is an ongoing debate about how cancer and dementia relate to each other, and whether their relation is biologically determined or caused by surveillance and survival bias. We aimed to circumvent these biases by determining the relation between the tumor marker carcinoembryonic antigen (CEA) and the risk of dementia in 6,692 participants from the population-based Rotterdam Study. We found that higher levels of CEA were associated with a higher risk of dementia (HR per standard deviation increase in CEA = 1.11, 95% CI 1.04; 1.18). This finding may indicate that cancer and dementia are positively associated, but the mechanisms underlying the relation between CEA and dementia warrant further investigation.
Towards building a Urdu Language Corpus using Common Crawl
Authors: Shafiq Hafiz Muhammad , Tahir Bilal , Mehmood Muhammad Amir
Published: June 2020

Urdu is the most popular language in Pakistan which is spoken by millions of people across the globe. While English is considered the dominant web content language, characteristics of Urdu language web content are still unknown. In this paper, we study the World-Wide-Web (WWW) by focusing on the content present in the Perso-Arabic script. Leveraging from the Common Crawl Corpus, which is the largest publicly available web content of 2.87 billion documents for the period of December 2016, we examine different aspects of Urdu web content. We use the Compact Language Detector (CLD2) for language detection. We find that the global WWW population has a share of 0.04% for Urdu web content with respect to document frequency. 70.9% of the top-level Urdu domains consist of . com, . org, and . info. Besides, urdulughat is the most dominating second-level domain. 40% of the domains are hosted in the United States while only 0.33% are hosted within Pakistan. Moreover, 25.68% web-pages have Urdu as primary language and only 11.78% of web-pages are exclusively in Urdu. Our Urdu corpus consists of 1.25 billion total and 18.14 million unique tokens. Furthermore, the corpus follows the Zipf’s law distribution. This Urdu Corpus can be used for text summarization, text classification, and cross-lingual information retrieval.
“Bend the truth”: Benchmark dataset for fake news detection in Urdu language and its evaluation
Authors: Amjad Maaz , Sidorov Grigori , Zhila Alisa , Gómez-Adorno Helena , Voronkov Ilia , Gelbukh Alexander
Published: June 2020

The paper presents a new corpus for fake news detection in the Urdu language along with the baseline classification and its evaluation. With the escalating use of the Internet worldwide and substantially increasing impact produced by the availability of ambiguous information, the challenge to quickly identify fake news in digital media in various languages becomes more acute. We provide a manually assembled and verified dataset containing 900 news articles, 500 annotated as real and 400, as fake, allowing the investigation of automated fake news detection approaches in Urdu. The news articles in the truthful subset come from legitimate news sources, and their validity has been manually verified. In the fake subset, the known difficulty of finding fake news was solved by hiring professional journalists native in Urdu who were instructed to intentionally write deceptive news articles. The dataset contains 5 different topics: (i) Business, (ii) Health, (iii) Showbiz, (iv) Sports, and (v) Technology. To establish our Urdu dataset as a benchmark, we performed baseline classification. We crafted a variety of text representation feature sets including word n-grams, character n-grams, functional word n-grams, and their combinations. After applying a variety of feature weighting schemes, we ran a series of classifiers on the train-test split. The results show sizable performance gains by AdaBoost classifier with 0.87 F1Fake and 0.90 F1Real. We provide the results evaluated against different metrics for a convenient comparison of future research. The dataset is publicly available for research purposes.
A GMCDM approach with linguistic Z-numbers based on TOPSIS and Choquet integral considering risk preference
Authors: Tao Ran , Xiao Fuyuan
Published: June 2020

Group multi-criteria decision-making (GMCDM) is an important part of decision theory, which is aimed to assess alternatives according to multiple criteria by collecting the wisdom of experts. However, in the process of evaluating, because of the limitation of human knowledge and the complexity of problems, an efficient GMCDM approach under uncertain environment still need to be further explored. Thus, in this paper, a novel GMCDM approach with linguistic Z-numbers based on TOPSIS and Choquet integral is proposed. Firstly, since linguistic Z-numbers performs better in coping with uncertain information, it is used to express the evaluation information. Secondly, TOPSIS, one of the most useful and systematic multi-criteria decision-making (MCDM) method, is adopted as the framework of the proposed approach. Thirdly, frequently it exists interaction between criteria, so Choquet integral is introduced to capture this kind of influence. What’s more, viewing that decision makers (DMs) show different preferences for uncertainty, the risk preference is regarded as a vital parameter when calculating the score of linguistic Z-numbers. An application in supplier selection is illustrated to demonstrate the effectiveness of the proposed approach. Finally, a further comparison and discussion of the proposed GMCDM method is given.
Inter-temporal characterization of aggregate residential demand based on Weibull distribution and generalized regression neural networks for scenario generations
Authors: Afzaal Muhammad Umar , Sajjad Intisar Ali , Khan Muhammad Faisal Nadeem , Haroon Shaikh Saaqib , Amin Salman , Bo Rui , ur Rehman Waqas
Published: June 2020

The characterization of electrical demand patterns for aggregated customers is considered as an important aspect for system operators or electrical load aggregators to analyze their behavior. The variation in electrical demand among two consecutive time intervals is dependent on various factors such as, lifestyle of customers, weather conditions, type and time of use of appliances and ambient temperature. This paper proposes an improved methodology for probabilistic characterization of aggregate demand while considering different demand aggregation levels and averaging time step durations. At first, a probabilistic model based on Weibull distribution combined with generalized regression neural networks (GRNN) is developed to extract the inter-temporal behavior of demand variations and, then, this information is used to regenerate aggregate demand patterns. Average Mean Absolute Percentage Error (AMAPE) is used as a statistical indicator to assess the accuracy and effectiveness of proposed probabilistic modeling approach. The results have demonstrated that the performance of proposed approach is better in comparison with an existing Beta distribution-based method to characterize aggregate electrical demand patterns.
Inclusion through technology and education: A commitment to the improvement of museographic cultural spaces
Authors: de Prado Jose Enrique Llamazares , Gago Ana Rosa Arias
Published: June 2020

In the following research, we intend to highlight the importance of inclusion in the museum spaces, being the key the educational value, with the use of the new tools (ICTs), as well as the interculturality showing the diversity of the current cities in its cultural aspect, and allowing the access to all type of public, with functional diversity. A systematic review has been carried out with a selection of 490 articles examined up to 56 articles from 2002 to October 2017. The search was conducted using ten databases: Esci, Circ, Miar, Eric, Isoc, Dialnet, Scopus, Google Scholar, Teacher Reference Center and Wos. The purpose is to provide elements to carry out good practices that facilitate inclusive education and avoid cultural exclusion. Within the conclusions obtained, the role of the museum space as a place of reflection and grouping of different intergenerational groups is evident. The incorporation of ICTs that improve interaction and learning should be encouraged, valuing cooperation between museums and schools.
Assessment of an intelligent robotic rollator implementing navigation assistance in frail seniors
Authors: Koumpouros Yiannis , Toulias Thomas L. , Tzafestas Costas S. , Moustris George
Published: June 2020

BACKGROUND:

Assistive technologies are playing vital role in frail seniors.

OBJECTIVE:

The paper presents the methodology and findings from the assessment of an active “intelligent” robotic rollator incorporating navigation assistance in frail seniors.

METHODS:

Thirty seniors, having moderate motor impairment were grouped into two categories according to their cognitive status. A complicated trail was defined to test their performance using a robotic rollator. The main descriptive statistics were given, while inference was performed via the corresponding parametric [Formula: see text] tests and the non-parametric Mann-Whitney U or Kruskal-Wallis tests. A principal component analysis was utilized to extract the variable classes that explain the overall behavior of the sample.

RESULTS:

Navigation assistance was proved helpful to the cognitive impaired group. The results between the two groups were comparable in terms of completion time and success rate. The provided directional audio cues led to smoother walking paths and better orientation. There was no correlation between the MMSE values and the total time of the walk ([Formula: see text] 0.696 [Formula: see text] 0.05 for Pearson’s correlation between MMSE and total walk time).

CONCLUSIONS:

The integration of navigation assistance in mobility assistance devices can help the elderly to effectively orient themselves in challenging and unknown environments.
A Virtual Reality based serious game to aid in the literacy of students with intellectual disability: Design principles and evaluation
Authors: de Vasconcelos Daniel Felipe Pereira , Júnior Edgard Afonso Lamounier , de Oliveira Malaquias Fernanda Francielle , Oliveira Luciana Aparecida , Cardoso Alexandre
Published: June 2020

BACKGROUND:

Literacy is essential for the development and empowerment of students with intellectual disability. However, such students often present limitations that may interfere in their literacy process.

OBJECTIVE:

The aim of this research was to evaluate the potential of Virtual Reality as an educational tool to support the literacy process of students with intellectual disability.

METHODS:

We have developed a serious game based on Virtual Reality techniques. The game has been validated by special education professionals and used by students and their teachers in two inclusive schools. In order to evaluate the game’s effectiveness, a qualitative methodology has been adopted.

RESULTS:

The study points to a positive evaluation of the game as a tool to aid in the development of literacy skills of students with intellectual disability.

CONCLUSIONS:

The results indicate that Virtual Reality has potential to contribute to the inclusion of students with intellectual disability in the educational context.
Differentiating pneumonia with and without COVID-19 using chest CT images: from qualitative to quantitative
Authors: Li Zicong , Zeng Bingliang , Lei Pinggui , Liu Jiaqi , Fan Bing , Shen Qinglin , Pang Peipei , Xu Rongchun
Published: June 2020

BACKGROUND:

Pneumonia caused by COVID-19 shares overlapping imaging manifestations with other types of pneumonia. How to objectively and quantitatively differentiate pneumonia patients with and without COVID-19 virus remains clinical challenge.

OBJECTIVE:

To formulate standardized scoring criteria and an objective quantization standard to guide decision making in detection and diagnosis of COVID-19 virus induced pneumonia in clinical practice.

METHODS:

A retrospective dataset includes computed tomography (CT) images acquired from 43 pneumonia patients with COVID-19 virus detected by reverse transcription-polymerase chain reaction (RT-PCR) tests and 49 pneumonia patients without COVID-19 virus. All patients were treated during the same time period in two hospitals. Key indicators of differential diagnosis were identified in relevant literature and the scores were quantified namely, patients with more than 8 points were identified as high risk, those with 6–8 points as moderate risk, and those with fewer than 6 points as low risk for COVID-19 virus. In the study, 3 radiologists determined the scores for all patients. Diagnostic sensitivity and specificity were subsequently calculated.

RESULTS:

A total of 61 patients were determined as high risk, among which 42 were COVID-19 positive by RT-PCR tests. Next, 9 were identified as moderate risk, one of whom was COVID-19 positive. Last, 22 were classified into the low-risk group, all of them are COVID-19 negative. Based on these results, the sensitivity of detection COVID-19 positive cases between the high-risk group and the non-high-risk group was 0.98 with 95% confidence interval [0.88, 1.00], and the specificity was 0.61 [0.46, 0.75]. The detection sensitivity between the moderate-/high-risk group and the low-risk group was 1.00 [0.92, 1.00], and the specificity was 0.45 [0.31, 0.60].

CONCLUSION:

The proposed quantitative scoring criteria showed high sensitivity and moderate specificity in detecting COVID-19 using CT images, which indicates that these criteria may be beneficial for screening in real-world practice and helpful for long-term disease control.
Problemas de comercio exterior
Authors: Gorosquieta Javier
Published: June 2020

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Europa y sus valores (II)
Authors: Ferrer Pi Pedro
Published: June 2020

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Falsa libertad sindical
Authors: Martín Sanz Felipe
Published: June 2020

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La doctrina social católica y la economía de los EE.UU.
Authors: Higuera Gonzalo
Published: June 2020

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Por una sociedad sin droga
Authors: Redacción Consejo de
Published: June 2020

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En torno a Keynes hoy
Authors: Gorosquieta Javier
Published: June 2020

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La ética de los jóvenes y el nuevo orden económico
Authors: Riaza José María
Published: June 2020

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¿Desde la ética deportiva hacia la ética social?
Authors: Caballero Francisco Javier
Published: June 2020

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未来高职院校体育课程建设
Authors: 陈 海波
Published: June 2020

高职院校主要目的是培养应用型人才，未来高职院校体育课程建设过程中，应要将体育教学与学生专业情况相结合，培养学生体育综合能力和职业发展能力。因此，本文找出高职院校体育课堂存在的问题，提出未来高职院校体育课程建设发展方向，促进学生的全面发展，为今后的学习和生活打下坚实的基础。
基于“1+X”证书制度下诊断与改进模式的线上线下混合式课程教学改革研究
Authors: 杨 敬江 , 刘 娇
Published: June 2020

在职业院校实施“1+X”证书制度是深化复合型技术技能人才培养模式和评价模式改革，提高人才培养质量的一项重要举措。文章以《汽车故障检修综合实训》课程为例，针对高职课堂教学诊断技术落后，形式单一、反馈滞后等现象，提出从“8字螺旋”的视角，试探性地将“8字形质量 改进螺旋”与高职课堂教学诊断与改进联系起来，给出构建动静态“8字螺旋”的关键技术点，实现O2O混合式课程全过程、全方位常态化地实时诊断，不断提高教学质量和课程的建设水平。
生态化视角下英语笔译教学的现状与发展
Authors: 李 尚莹
Published: June 2020

教学生态系统是由教师、学生、教学资料、教学活动、教学手段、教学设备、教辅工具等一切与教学相关的生态因子所组成的一个生态系统。英语专业笔译课堂也是一个有机的、动态发展的生态系统。目前人工智能和网络翻译软件以及计算机辅助翻译软件的逐步结合给英语笔译教学生态系统带来了前所未有的挑战和发展机遇。本文从教学生态化、英语笔译教学生态现状、英语笔译教学发展等方面展开研究与思考。
冠心病患者自我感受负担中介效应分析
Authors: 许 阳
Published: June 2020

目的：分析冠心病患者自我感受负担现状，探讨冠心病患者自我感受负担对疾病感知和生存质量的中介效应，为改善冠心病患者生存质量提供参照。方法：采用自我感受负担量表、疾病感知问卷和SF-36生存质量简表对2016年12月至2017年12月在徐州医科大学附属医院心内科住院的204名冠心病患者进行调查。结果：Pearson相关分析显示患者自我感受负担与生存质量呈显著负相关r= -0.672，p
“移动式学习+翻转课堂”在高职院校工科类课程教学中的改革探索
Authors: 刘 慧娟 , 朱 旭东 , 张 爱良
Published: June 2020

工科类课程基础连贯性比较强，传统课堂教学模式已不利于高职技能人才的培养。本文阐述了高职工科类课程在传统教学下的困境，在此基础上提出了“移动式学习+翻转课堂”的教学方法，并指出了实施该教学方法的关键要素。
回归本分导向下探究高校教师如何潜心教书育人
Authors: 孙 景 , 葛 芳玉
Published: June 2020

教育部陈宝生部长在全国本科教育工作大会上提出要推进教师回归本分，推动本科教育重新回到大学办学的核心基础地位。回归本分就是回归到教书育人这一主题上来，教师要回归以本为本教育理念，坚持立德树人，坚持学生中心，坚持热爱学生，坚持服务引导；要回归创新教学育人体系，优化前沿技术，推进课程创新，加强教学规范，倡导价值追求；要回归做“四好”教师追求，坚守崇高理想信念，培养高尚道德情操，构建渊博扎实学识，常怀宽厚仁爱之心，切实提高参与本科教育的积极性和主动性，提高授课质量和育人责任，坚持需求导向，坚持立德树人，提高教学效果，提升人才培养质量。
新时代高校少数民族大学生党员发展的研究与对策
Authors: 胡 涛
Published: June 2020

现阶段，我国存在着各种不同程度的民族问题，这些问题从不同的层面影响着社会进步、经济建设和民族文化发展。少数民族大学生既是国家发展所需要的栋梁之材，也是少数民族地区发展的有力推动者，而少数民族学生党员无疑肩负着榜样的使命。高校学生党员发展培养工作是一个系统性的工程。如何通过对党建文化认识的总结，顺应当前思政工作改革，去探索面对高校少数民族学生不同的特点；如何从战略高度认识少数民族学生党员发展工作的重要性，创新发展培养模式，构建具有时效性、针对性的发展培养的全程化管理方法和入党标准是本文主要探讨的内容。
青岛红色资源进高校公寓党建路径探析
Authors: 徐 兆娟 , 张 玲
Published: June 2020

在高校公寓党建中深度挖掘身边的红色资源，积极探索学生党建工作进公寓的新途径，讲好红色故事，传承红色基因，深化红色主题教育，营造良好的育人氛围，努力把高校学生公寓建成思想政治教育新高地，让红色文化涤荡灵魂塑造大学生坚忍不拔的品格，让广大青年学生在革命先烈的事迹中接受革命传统教育，坚定共产主义信念，激发学生爱国热情。
一带一路背景下天津跨境电商发展现状及建议
Authors: 赵 建辉
Published: June 2020

本文从2001年中国加入世界贸易组织，2013年习近平主席发起一带一路倡议至今，分析中国跨境电商发展以及天津的发展状况，就如何挖掘一带一路的商机，以及天津的跨境电商发展如何融入京津冀一体化发展战略，提出了天津跨境电商产业发展的建议。
Técnica EXIT como manejo de la vía aérea en masas gigantes congénitas de cuello
Authors: Orrego G. Jaime , Mosquera-Hernández Juan Camilo , Ardila-Giraldo Santiago , Torres-Canchala Laura , Alzate Edgar , Benavidez Juan Pablo
Published: June 2020

Las masas congénitas de cabeza y cuello se asocian a asfixia perinatal e injuria cerebral con elevada mortalidad. La técnica EXIT (Ex Útero Intrapartum Treatment) consiste en asegurar la vía aérea del neonato, sin interrumpir la oxigenación y perfusión materno-fetal a través del soporte placentario. Esta técnica no ha sido estandarizada en países de medianos ingresos.Objetivo: Describir el caso clínico de 2 neonatos manejados mediante la técnica EXIT.Caso Clínico: Se reportan dos casos, uno con malformación linfática diagnosticada a la semana 20 gestación y el segundo con tiromegalia y polihidramnios diagnosticados a la semana 35 de gestación. En ambos casos, durante la cesárea se realizó la técnica EXIT con un equipo conformado por neonatólogo, ginecólogo, anestesiólogo, cirujano pediatra, otorrinolaringólogo, enfermero y terapeuta respiratorio. En los dos pacientes se logró asegurar la vía aérea mediante intubación orotraqueal al primer intento. En el caso 1 se confirmó la malformación linfática y recibió escleroterapia, y en el caso 2 se diagnosticó hipotiroidismo congénito asociado a bocio, que fue manejado con levotiroxina. Los pacientes se mantuvieron 7 y 9 días con ventilación mecánica invasiva respectivamente y egresaron sin complicaciones respiratorias.Conclusiones: La técnica EXIT en estos casos fue un procedimiento seguro, llevado a cabo sin inconvenientes. Se necesita un equipo multidisciplinario y la disponibilidad de una unidad de cuidados intensivos neonatales, con el objetivo de reducir potenciales complicaciones y garantizar el manejo postnatal. Para lograr su ejecución, es indispensable el diagnóstico prenatal oportuno.
Trastornos hereditarios de la coagulación en adolescentes con sangrado menstrual excesivo, ¿Debemos evaluar la vía fibrinolítica?
Authors: N. Aguirre , J. Pereira , F. Barriga , MA. Wietstruck , O. Panes , P. Sepulveda , A. Salgado , P. Zuñiga
Published: June 2020

El Sangrado Menstrual Excesivo (SME) es un problema frecuente en la adolescencia. La prevalencia de trastornos hereditarios de la coagulación (THC) como causa del SME no está bien establecida y la participación de defectos de la vía fibrinolítica   ha sido poco explorada.Objetivo: determinar la prevalencia de THC y defectos de la fibrinólisis en adolescentes con SME.Pacientes y Método: Se incluyeron 93 adolescentes, edad 11 a 18 años. Los antecedentes personales y familiares de sangrado se obtuvieron con un cuestionario estandarizado. Se controló exámenes: tiempo de protrombina (TP), tiempo de tromboplastina parcial activada (TTPa), estudio del factor Von Willebrand, recuento y función plaquetaria. Los pacientes que no fueron diagnosticados como THC, se evaluaron adicionalmente con el tiempo de lisis del coágulo.Resultados: 41 pacientes (44%) fueron diagnosticados como THC: Enfermedad de Von Willebrand n=28, defectos de la función plaquetaria n=8, hemofilia leve n=5. Se confirmó disminución del tiempo de lisis del coágulo en 31 pacientes. El 54% de pacientes diagnosticado como THC,  tuvo SME como la primera manifestación hemorrágica. Conclusión: Estos resultados apoyan la necesidad de evaluación de la coagulación, incluyendo la vía fibrinolítica, en el estudio de adolescentes con SME.
Eje Renina Angiotensina, Enzima Convertidora de Angiotensina 2 y Coronavirus
Authors: Cano F. , Gajardo M. , Freundlich M.
Published: June 2020

El sistema renina angiotensina aldosterona (SRAA) es el principal regulador del volumen plasmático, manteniendo la homeostasis cardiovascular e hidrosalina. En la vía clásica, la enzima convertidora de angiotensina (ECA) genera Angiotensina II (AngII), de potente efecto inflamatorio y vasoconstrictor. Esta vía clásica es a su vez regulada por la ECA2, que convierte AngII a Ang 1-7, cuyas acciones vasodilatadoras y antiinflamatorias dan balance a los efectos de AngII. La ECA2 se ha relacionado con la patogenia de infecciones respiratorias como el virus respiratorio sincicial y el síndrome respiratorio agudo grave por coronavirus (SARS-CoV y SARS-CoV-2). Estudios recientes han demostrado que la ECA2 corresponde al principal receptor del SARS-CoV-2, que en conjunto con otros receptores como la serin proteasa TMPRSS2, permiten la fijación, fusión y entrada del virus a la célula huésped. En animales infectados por SARS-CoV se produce una caída de la concentración tisular de ECA2 y Ang 1-7, con la consiguiente sobreexpresión de AngII, y sus efectos vasoconstrictores e inflamatorios. Experimentos con ECA2 recombinante han mostrado un efecto protector frente a la sobreexpresión del SRAA en animales infectados por SARS-CoV, efecto similar al demostrado con el uso de bloqueadores del receptor de AngII, AT1. La evidencia sobre el rol protector de ECA2 parece respaldar las recomendaciones respecto a no suspender estos medicamentos en la infección SARS-CoV-2. En este artículo presentamos el conocimiento actual sobre el rol del SRAA en la infección por SARS-CoV, a partir de conceptos fisiopatológicos, bases moleculares, y evidencia experimental y clínica.
Aplicación de una nueva terminología “BRUE: eventos breves, resueltos e inexplicados”. Definiciones y recomendaciones
Authors: Zenteno Araos Daniel , Díaz Silva Javiera , Brockmann Veloso Pablo
Published: June 2020

Hace tres décadas se propuso el término Apparent Life-Threatening Events (ALTE), siendo incorporado paulatinamente en el enfrentamiento clínico de estos pacientes; permitiendo determinar riesgos, atribuir causas y realizar tratamientos específicos. Sin embargo, llevó a realizar estudios y hospitalizaciones en muchas instancias considerados innecesarios, generando un aumento de los costos sanitarios. Por estos motivos nace el concepto de Brief Resolved Unexplained Events (BRUE), que pretende disminuir la subjetividad del evento y focalizar una estrategia de manejo según determinación del riesgo. En el siguiente artículo se analizan diferencias entre ALTE y BRUE según consensos internacionales y chilenos, profundizando en el enfrentamiento e incorporando consideraciones de relevancia para la práctica clínica cotidiana de lactantes que presentan un BRUE.
Le forme del narcisismo covert e il trattamento con la Terapia Metacognitiva Interpersonale
Authors: Centonze Antonella , Manfredi Chiara , Popolo Raffaele , Dimaggio Giancarlo
Published: June 2020

La Terapia Metacognitiva Interpersonale (TMI) è stata formalizzata in particolare per pazienti con disturbi di personalità a prevalente sovra-regolazione emotiva e comportamentale. In questi pazienti gli aspetti di sofferenza sono innescati e sostenuti da schemi interpersonali maladattivi, metacognizione compromessa e conseguenti coping disfunzionali. All'interno della stessa categoria diagnostica di Disturbo Narcisistico di Personalità si ritrovano pazienti con schemi interpersonali e coping che rendono evidenti diversi sottotipi di narcisismo; a partire da ciò proporremo un modello alternativo alla tradizionale distinzione tra narcisismo covert e overt. Mostreremo, quindi, come in TMI la formulazione del caso costituisca la base del trattamento e illustreremo con un caso clinico come la l'intervento TMI sugli schemi tramite l'uso di tecniche esperienziali e la regolazione della relazione terapeutica.
Immagini e simboli della relazione. Il caso di Nicola
Authors: Picerno Angelo
Published: June 2020

Partendo da un resoconto clinico, l'autore propone una rilettura analitica di un percorso psicologico ad orientamento sistemico relazionale interrottosi, con un duplice senso di successo e fallimento, a conclusione del quarto incontro. Duplice è anche lo sguardo con cui il caso viene ripreso, intrecciando tra loro il tema delle immagini, di cui l'incontro è particolarmente ricco e la dinamica di transfert/controtransfert, quale indicatore prezioso circa l'emergenza di aspetti complessuali inconsci nella relazione. Prodotto di tale commistione è una riflessione su altri scenari possibili, laddove tali variabili (immagini e relazione) avessero trovato declinazione diversa nel corso del lavoro svolto.
Preispitivanje pariteta kupovne snage u Hrvatskoj
Authors: Bošnjak Mile , Bilas Vlatka , Novak Ivan
Published: June 2020

Na uzorku mjesečnih podataka o realnom efektivnom tečaju kune od siječnja 1996. godine do listopada 2018. godine, u radu se analizira teorija pariteta kupovne snage u Hrvatskoj. Testovi jediničnog korijena sugeriraju nestacionarnu vremensku seriju realnog efektivnog tečaja kune. Temeljem modela kvantilne autoregresije u radu su analizirani endogeni šokovi različitog predznaka i magnitude. Rezultati sugeriraju postojanje asimetrija. Aprecijacijski šokovi u realnom efektivnom tečaju kune perzistiraju kraće u odnosu na deprecijacijske šokove. Nadalje, endogeni šokovi oko medijana imaju najizraženiju tendenciju perzistencije. Zaključno, rezultati svih provedenih istraživanja u ovom radu ne podržavaju teoriju pariteta kupovne snage na primjeru iz Republike Hrvatske.