bluuebunny/crossref_metadata_2025 huggingface dataset:
Tecnologia cuidativa subsídio para consulta de enfermagem em pessoas com hipertensão e diabetes: estudo metodológico
Authors: Pena Laidiane Dantas Soares , Silva Ananada Larisse Bezerra da , Ribeiro Adriane Stefanny Rocha , Silva Jéssica Gomes da , Pena José Luis da Cunha , Pena Francineide Pereira da Silva , Ferreira Diego Quaresma , Ferreira Cecília Rafaela Salles
Published: January 2025

Objetivo: Validar tecnologia cuidativa para o processo de enfermagem no atendimento às pessoas com Diabetes Mellitus e Hipertensão Arterial Sistêmica. Método: estudo metodológico de validação de conteúdo e aparência. Utilizou-se a estatística descritiva e o teste binomial considerando o nível de significância de 5% para a obtenção do índice de validade. Para validação de conteúdo participaram nove especialistas e 16 enfermeiroes (público-alvo), para validação de aparência participaram sete profissionais design. Resultado: a tecnologia teve Índice de Validade de Conteúdo de 0,94 (p<0,001) profissionais-especialistas, de 0,88 (p<0,001) profissionais-público-alvo e Índice de Validade de Aparência 0,85 (p<0,001) profissionais-design. As sugestões dos profissionais contribuíram para a revisão da tecnologia e foram incluídas na versão final, que contém 59 páginas, frente e verso. Conclusão: a tecnologia foi validada, quanto conteúdo e aparência, podendo ser utilizada como dispositivo mediador pelos enfermeiros da atenção primária, na consulta de enfermagem contribuindo na qualidade do cuidado às pessoas com diabetes e hipertensão.
Teks Naratif Favorit Pilihan Siswa Sekolah Menengah Atas Menggunakan Instrumen Google Form
Authors: Nurhuda Aris , Djawa Alex , Pane Betharia
Published: January 2025

Penelitian ini bertujuan untuk mendeskripsikan: 1) teks naratif favorit pilihan siswa kelas X SMA Negeri 7 Kupang; 2) sama-tidaknya teks naratif favorit pilihan siswa kelas X SMA Negeri 7 Kupang per kelompok sampel. Penelitian ini berlangsung di semester ganjil 2024/2025. Populasi penelitian ini adalah para siswa X SMA Negeri 7 Kupang yang mengisi kuesioner di google form yang disebarkan secara acak via guru Bahasa Indonesia berbasis WhatsApp. Mereka berjumlah 129 siswa yang terbagi dari 6 kelas paralel. Sampel ditetapkan 98 siswa; sesuai dengan formula Slavin. Jumlah sampel per kelompok ini ditetapkan secara proporsi yang dirarik secara random sederhana tanpa pengembalian. Teks naratif yang dimaksud dalam artikel ini adalah teks eksposisi topik IPA, teks ekposisi topik matematika, teks prosedur topik IPA, dan teks prosedur topik matematika. Untuk mengumpulkan data teks naratif favorit pilihan siswa kelas X SMA Negeri 7 Kupang digunakan instrumen kuesioner via google form dengan sistem tertutup yang memenuhi syarat validitas isi. Data teks naratif favorit pilihan siswa kelas X SMA Negeri 7 Kupang dianalisis menggunakan korelasi kontingensi melalui penghitungan manual. Daftar cek-ricek digunakan untuk memvalidasi data google form melalui excel dan memvalidasi secara internal hasil penghitungan korelasi kontingensi. Temuan penelitian: 1) teks naratif favorit pilihan siswa kelas X SMA Negeri 7 Kupang adalah teks eksposisi; 2) terdapat perbedaan teks naratif favorit pilihan siswa kelas X SMA Negeri 7 Kupang per kelompok sampel.
O DOCUMENTO E O ARQUIVO NOS MUSEUS DE ARTE: APONTAMENTOS NO CONTEXTO CONTEMPORÂNEO BRASILEIRO
Authors: Catique Letícia
Published: January 2025

Nessas duas últimas décadas viu-se o boom da memória, e esse, talvez, tenha sido o combustível para a aproximação entre lugares e práticas de memória. A relação documento, arquivo e museu de arte, antes pareciam muito mais campos de funções e conceitos isolados entre si, sob esse prisma, ganha complexidade. Não se pode perder de vista que as obras contemporâneas, seja em sua materialidade, seja a partir da necessidade do registro devido a sua efemeridade, passaram a produzir um volume expressivo de documentos cujo destino, na maioria das vezes, são os museus. Vale questionar, nesse sentido, como os museus de arte incorporaram práticas arquivísticas para lidar com conjuntos documentais? Buscando respostas, esse projeto, ao se estruturar em terreno multidisciplinar, propõe uma incursão sobre o tema a partir de um diálogo com a arte, a memória, a história, a arquivologia e a museologia, tencionando refletir sobre o documento e o arquivo no museu de arte e quais as funções a eles relegadas no contexto contemporâneo brasileiro.
AUGUSTO BOAL, O TEATRO DE ARENA E A CRÔNICA JORNALÍSTICA CURITIBANA (1956-1979)
Authors: Mattana Márcio Luiz
Published: January 2025

O presente artigo busca mapear e comentar a presença e circulação das ideias de Augusto Boal e do Teatro de Arena na crônica jornalística de Curitiba, especificamente entre 1956 e 1979, na tentativa de caracterizar as relações de aproximação e influência que ocorreram entre o referido grupo paulista e a cena teatral da cidade naqueles anos. Partindo dos registros jornalísticos da época, a pesquisa identifica e descreve as diversas fases da recepção das ideias de Augusto Boal pelos jornais curitibanos, desde sua chegada ao Teatro de Arena até a fase dos musicais, da formulação do sistema coringa e do teatro jornal. A partir das pistas levantadas, o artigo estabelece elos de contato entre o contexto histórico, os movimentos da cena teatral nacional e seus ecos no teatro curitibano da época, buscando evidenciar o impacto deste processo na modernização da cena teatral da cidade.
CONTRIBUIÇÕES DA RESIDÊNCIA PEDAGÓGICA PARA FORMAÇÃO DOS LICENCIADOS EM PEDAGOGIA DA UNIVERSIDADE ESTADUAL DE GOIÁS, 2018-2019
Authors: Goulart Joana Corrêa , Silva Andreia Cristina da
Published: January 2025

Esta pesquisa que tem como objeto de estudo a formação inicial de professores. Aborda o seguinte problema de pesquisa: Quais foram as contribuições do Programa Residência Pedagógica (PRP) para a formação dos egressos do curso de Pedagogia da UEG Campus Sudoeste, Sede Quirinópolis? O objetivo geral da pesquisa é compreender as contribuições do PRP para a formação docente em Pedagogia. Os objetivos específicos são: analisar a proposta do PRP apresentadas no Edital CAPES/MEC nº 06/2018; identificar as principais ações desenvolvidas no âmbito da Residência Pedagógica do Curso de Pedagogia da UEG-Campus Sudoeste, Sede Quirinópolis; discutir as contribuições do PRP, para a formação dos egressos do Curso de Pedagogia participantes desse programa em 2018-2019. Realizou-se uma pesquisa bibliográfica com fundamentos nas discussões e produções científicas sobre formação docente bem como o estudo da legislação pertinente a formação de professores no Brasil e estudo do primeiro Edital da Capes para desenvolvimento do PRP. Foi realizada, também, uma pesquisa de campo com aplicação de um questionário e entrevista com os egressos do curso de pedagogia que participaram desse Programa. Os resultados esperados pela pesquisa foram a compreensão das contribuições do PRP para a formação dos professores do curso de pedagogia bem como o acompanhamento do desempenho profissional desses egressos. Os questionários foram enviados via Google forms e recebidos da mesma forma. A pesquisa foi relevante para os objetivos institucionais da formação de professores oferecida pela UEG e para a agenda acadêmica do Instituto Acadêmico de Educação e Licenciaturas (IAEL), visto a produção de conhecimento sobre o PRP desenvolvidos no âmbito de um curso de licenciatura no primeiro edital da Capes para essa finalidade.
PENINGKATAN DAYA SAING UMKM MELALUI STRATEGI BRANDING YANG EFEKTIF DAN INOVATIF
Authors: Kuncara Tommy , Ariyanto Ariyanto , Immi Fiska Tarigan  , Sri Wahyu Handayani
Published: January 2025

Enhancing the competitiveness of Micro, Small, and Medium Enterprises (MSMEs) is a key focus in supporting national economic growth. This community service program aims to provide training and guidance for MSME actors on effective and innovative branding strategies to improve their ability to compete in local and national markets. The program is a collaboration between Gunadarma University and the Indonesian Association of Young Lecturers (ADMI), conducted during the PTA 2024/2025 academic year through online and offline sessions. The program integrates the university's expertise in Information and Communication Technology (ICT), involving four faculties and ten related disciplines, such as information systems, accounting, and communication studies. The training includes digital branding, brand identity management, and technology-based marketing strategies. This program is expected to enhance the skills of MSME actors in building competitive brands and produce outputs such as scientific publications, activity documentation, and increased lecturer participation in community service initiatives.
PAULO FREIRE E O CURRÍCULO ESCOLAR – DA PRÁTICA COTIDIANA DOS EDUCANDOS À SUPERAÇÃO DA “EDUCAÇÃO BANCÁRIA”
Authors: Dos Santos Antonio Nacílio Sousa , Neves Carlos Rigor , Santana Everaldo Costa , Cabelleira Peterson Ayres , Da Silva Joner Ney Vieira , Lima Uanderson da Silva , De Sousa Rafael Aranha , Da Silva Gabriel Alves , Di Migueli Caio Oliveira , da Silva Sonaí Maria , Batista Wagner Roberto , Silva Victor Emanuel do Nascimento , Alves Dálcio Rosário , de Farias Bruna Gonzaga , Dos Reis Cristiana Silva
Published: January 2025

No exercício cotidiano da prática escolar, é frequente que decisões sejam tomadas sem a devida escuta dos educandos. Esse distanciamento implica o risco iminente de que o conteúdo trabalhado em sala de aula esteja desconectado da realidade vivenciada pelos sujeitos. Essa desconexão é agravada por uma relação hierárquica entre educador e educando, muitas vezes marcada pela transmissão unilateral de conhecimento, como se os alunos fossem meros “depósitos” nos quais os educadores depositam suas ideias. Ainda que essa prática nem sempre seja intencional, ela reflete e reproduz forças de dominação amplamente presentes no cotidiano da sociedade brasileira. Diante dessa realidade, surge a seguinte questão central: em uma sociedade tão heterogênea como a brasileira, como implementar um currículo escolar que dialogue com os anseios e necessidades dos educandos? Para refletir sobre esse desafio, tomamos como eixo teórico a obra “Pedagogia do Oprimido”, de Paulo Freire, além de autores como Mészáros (2002), Frigotto (2010), Saviani (2011), Tonet (2016) e Laval (2019), autores que contribuem para a compreensão da prática educativa emancipadora. Nesse sentido, discutimos a importância de considerar as experiências cotidianas dos educandos como ponto de partida para superar currículos escolares alheios às suas realidades e contextos socioculturais. Metodologicamente, adotamos uma abordagem qualitativa fundamentada em Minayo (2007), com base em uma pesquisa bibliográfica e descritiva conforme os estudos de Gil (2008). Além disso, utilizamos o viés analítico-compreensivo com o suporte teórico de Weber (1969). Os resultados apontam que a desconexão entre o currículo escolar e a realidade dos educandos prejudica o ensino-aprendizagem, perpetuando desigualdades e relações de poder assimétricas. Currículos descontextualizados desvalorizam as vivências dos estudantes, enquanto práticas pedagógicas que incorporam suas realidades promovem maior engajamento e autonomia crítica, alinhando-se à proposta de educação dialógica de Paulo Freire. Para isso, é necessário romper com a pedagogia bancária e capacitar os docentes para metodologias críticas e contextualizadas, garantindo um currículo inclusivo que fomente tanto o aprendizado quanto a transformação social.
IDENTIFICANDO A PREVALÊNCIA DE COEFICIENTES BETAS NEGATIVOS NO MERCADO ACIONÁRIO BRASILEIRO
Authors: Da Silva Luiza Carneiro , Pinheiro Carlos Alberto Orge
Published: January 2025

O presente estudo objetivou identificar a prevalência dos coeficientes betas negativos no mercado acionário brasileiro, com enfoque específico na verificação da estabilidade dos mesmos ao longo de dez anos (2013-2022), a partir de uma pesquisa quali-quantitativa descritiva. Considerando a importância do coeficiente beta para investidores que buscam formar carteira de ações com riscos reduzidos, a pesquisa analisou, em primeiro momento, os anos de 2013 a 2017 para determinar a presença de betas negativos, para então, no período subsequente (2018-2022), identificar a estabilidade deles. A metodologia do artigo foi iniciada a partir da coleta e análise das cotações históricas das empresas listadas na bolsa de valores brasileira (B3) durante os dez anos (2013-2022). No total, 85 ações prevaleceram no período descrito. Utilizando a fórmula derivada do modelo CAPM e com o auxílio da regressão linear simples, foram calculados os coeficientes betas de cada ação nos primeiros cinco anos, considerando o índice Bovespa como referência para o mercado, e depois o mesmo cálculo foi aplicado nos cinco anos subsequentes. Posteriormente, os coeficientes foram classificados em três categorias, seguindo o postulado por Gitman (2010): betas entre 0,5 e 1; acima de 1 e menores que 2; maiores que 2. Os resultados comprovam a hipótese de que não houve prevalência de betas negativos no tempo analisado. No entanto, a maioria dos coeficientes betas encontrados estavam entre 1 e 2, indicando uma superioridade de ações com sensibilidades próximas às oscilações do mercado. Além disso, a pesquisa revelou que os coeficientes betas analisados, especificamente 53,3% deles, tenderam a apresentar certa estabilidade ao longo do tempo estudado. Nem por isso, foram identificadas ações que apresentaram variações significativas no decorrer do tempo, o que pode indicar mudanças no desempenho dessas empresas. Conclui-se que, embora os betas negativos não foram encontrados no mercado acionário brasileiro entre 2013 a 2022, a estabilidade dos coeficientes das ações ao longo do tempo demonstra ser uma importante característica quando da análise de risco. Esse conhecimento é crucial para investidores que buscam estratégias de diversificação e gestão do risco das suas carteiras de ações.
Effect of Geinstein on Regulation of Estrous Cycle in Albino Rats, Isolated from Flemingia vestita, an Ethnomedicinally Important Plant of Meghalaya, India
Authors: Khatun Afsana , Ahmed Syed Rizaul Karim , Nag Sudipta , Sarma Kangkan Jyoti
Published: January 2025

Flemingia vestita is a flowering plant belonging to the family of Fabaceae which is usually found in the Indian region including Khasi and Jaintia Hills of Meghalaya, India. It is cultivated for therapeutic use for its anti-microbial, anti-fungal, anti-helmintic, anticancer, anti-rheumatic, anti-inflammatory, antioxidant, and anti-histamine activities. The present study is to ascertain the phytochemical analysis of the root-tuber extract and modulating the effect of the Estrous Cycle in albino mice using Geinstein. The phytoestrogens present in the extract are iso-flavones and genistein which have a wide spectrum of biological activities including estrogenic effect. The number of leucocytes during the Meta-estrous at 0.1 ml/10 gm dose/body weight was maximum at ethanol extract while at 0.3 ml/10 gm dose/body weight was similar and maximum in both ethanol and methanol extract. Comparative cell number of interstitial connective tissues was maximum in ethanol followed by methanol and acetone extract. The present study concluded that the extract has a potential to modulate the estrogenic cycle in albino rats.
La reescritura académica con herramientas de Inteligencia artificial en una universidad pública de México
Authors: Salazar González Crisanto , Verástica Cháidez María Luisa Guadalupe
Published: January 2025

Esta investigación tiene el propósito de analizar las prácticas de escritura y reescritura académica que los estudiantes de un programa de maestría en educación realizan al utilizar herramientas digitales para la elaboración de ensayos académicos. A través de un enfoque metodológico que integra la entrevista, el cuestionario y el análisis de contenido para comprender cómo las herramientas digitales influyen en la calidad del proceso de escritura y en el desarrollo de competencias investigativas. Se utilizó un cuestionario dirigido a catorce estudiantes provenientes de diversas licenciaturas, cuatro entrevistas semiestructuradas y trece ensayos académicos elaborados durante un seminario de maestría. Los hallazgos demuestran un uso limitado de estas herramientas y resultan poco efectivas en la calidad de la producción escrita de los estudiantes. Algunos consideran que aprender a usar herramientas como ChatGPT es una pérdida de tiempo, mientras que otros reconocen su utilidad para clarificar párrafos complejos. Sin embargo, el análisis de los ensayos mostró una limitada voz autoral en los argumentos y uso inadecuado de referencias en el discurso. El estudio concluye que existe una diversidad de prácticas discursivas que evidencian una brecha significativa en el uso de herramientas digitales para la escritura y rescritura académica entre estudiantes, sugiriendo la necesidad de profundizar en la integración de estas tecnologías para mejorar las prácticas y producción escrita en la formación universitaria.
Determinar índices de hemoglobina y hematocrito en sangre periférica de mujeres embarazadas de la parroquia de santa rosa, Cantón Ambato
Authors: Zumárraga Espinosa Virginia Magdalena , Sigcho Ajila Jimmy Andrés , Escobar Suárez Mónica Tatiana , Proaño Santamaria Jorge Luis , Jiménez Carrillo Daniel Alejandro
Published: January 2025

Se realiza un estudio cuantitativo, con diseño no experimental y descriptivo, de corte transversal, mediante la aplicación de tomas de muestras con frotis en sangre periférica, para la obtención de valores de hematocrito y hemoglobina, aplicado en grupo vulnerable de mujeres embarazadas de la parroquia rural GAD de Santa Rosa, provincia de Tungurahua utilizando criterios de exclusión, inclusión y eliminación, para la determinación de cuadros de anemia aguda. Los datos obtenidos son procesados en una matriz de Excel, para el cálculo de baremos se utiliza el programa de SPSS, posteriormente con estos valores se llegará a determinar valores bajos, medios y altos. Los resultados obtenidos corresponden al 49,6% de mujeres embarazadas presentan cuadros de anemia, en los datos obtenidos en el estudio tenemos un 19% de mujeres embarazadas con cuadros de anemia, estableciendo un amplio rango de diferencia a los datos indicados por la Guía de Práctica Clínica. Se observa la presencia de cuadros de anemia leves a moderados, lo que nos da a conocer que pueden ser su presentación de crónica, presentado en la edad fértil de las mujeres estudiadas entre 20 a 30 años, es importante fomentar cultura de prevención con la implementación de controles preconcepcionales, preparación de la mujer. El enfoque principal del estudio es establecer la realidad de la presencia de anemia aguda en las mujeres gestantes de nuestro país, como base para aplicación del método científico, evidenciando que el segundo periodo del embarazo es la etapa de mayor riesgo de cuadros de anemia aguda.
3D Modelling and numerical simulations of menisci in normal and osteoarthritic human knee joint
Authors:   Department of Applied Mechanics, University of Craiova, Tarnita Daniela , Catana Marius ,   INAS, Craiova
Published: January 2025

This paper presents 3D virtual modeling of the menisci in the human knee joint, based on CT sections performed on the human knee joint. CT images were processed using advanced modeling and simulation methods as Space Claim and Design Modeler integrated application under Ansys Workbench software package. By using Finite Element Analysis, the stresses and displacements from normal menisci, but also from those affected by osteoarthritis, are studied for the cases of 5 degrees valgus deviation of the mechanical axes of the knee. The study concludes with a comparison between the results obtained from the analysis performed for the healthy menisci, on the one hand, and for the damaged ones, on the other hand.
Cost–effectiveness of cetuximab combined with radiotherapy versus radiotherapy alone in locally advanced head and neck cancer in Spain
Authors: Cabellos Ruth Álvarez , Cacicedo Jon , Capafons Susana Redondo , los Santos Real Heidi De , Julián Miriam Brines , Rubio-Rodríguez Darío , Rubio-Terrés Carlos
Published: January 2025

Aim:
To estimate the cost–effectiveness of cetuximab in combination with radiotherapy compared with radiotherapy alone, for the treatment of locally advanced head and neck cancer patients in Spain.
Methods:
A probabilistic Markov model (second-order Monte Carlo simulation) with a five-year time horizon and quarterly Markov cycles was performed from the perspective of the Spanish National Health System (NHS).
Results:
The additional cost and quality-adjusted life-year (QALY) gain per patient receiving radiotherapy in combination with cetuximab compared with radiotherapy alone was €4356 (95% CI: €4350–4362) and 0.2380 (95% CI: 0.2370–0.2391) QALY, respectively. The incremental cost per QALY gain was €18,303 (95% CI: €18,243–18,354) with a probability of cost–effectiveness of 65.4% for a willingness to pay of €30,000 per QALY gained.
Conclusion:
According to the results of this analysis, the addition of cetuximab to radiotherapy would be a cost-effective alternative to radiotherapy alone in the treatment of locally advanced head and neck cancer in Spain.
Biomechanics of a Physically Impaired Individual from Early Medieval Ranelagh, Ireland
Authors: White Jessica , Murphy Eileen , Lennon Alex
Published: January 2025

This research describes the methods used to re-create the biomechanics of a physically impaired middle-aged male, SK67, dated 893–1023 C.E., from the early medieval cemetery at Ranelagh, Co. Roscommon, Ireland, who experienced an antemortem femoral head fracture. A gap in research exists between the osteological evidence and the nature of the true biomechanical gait. Computer simulation of musculoskeletal models is an emerging engineering approach to estimate true gait patterns from geometric measurements of skeletal anatomy. This study paves the way for bridging the gap between osteological evidence and true biomechanics by obtaining information from SK67 and using it to build a three-dimensional musculoskeletal model of SK67 using OpenSim. Gait was then simulated using SCONE software (a musculoskeletal simulation optimization system to predict task-specificmotion), thereby revealing SK67’s likely limb function post-impairment. The patterns of habitual biomechanical stress are reflected in the quantity and distribution of cortical bone; based on this approach, the individual’s limbs were compared for signs of weight-bearing by analyzing cortical bone thickness from radiographs. The upper limbs were also examined for entheseal changes that might indicate the use of walking aids. The results of these interdisciplinary methods enabled the biomechanics of SK67 to be revealed and assessed how SK67 would have used walking aids to regain mobility and independence in the wake of their major trauma. The lack of arms on the musculoskeletal models may provide a limitation to this study, as well as the errors/learning curve in altering inputfiles to simulate the gait. This method opens new avenues for future research into reconstructing the biomechanics of individuals with physical impairments within archaeological contexts, across both time and location.
Nosocomiale Infecties in België (deel II)
Authors: Vrijens France , Hulstaert Frank , Gordts Bart , De Laet Chris , Devriese Stephan , Van de Sande Stefaan , Huybrechts, Michel  , Peeters Gert
Published: January 2025

Studie nr : 2005-20
Chirurgie assistée par robot
Authors: Camberlin Cécile
Published: January 2025

Le Centre fédéral d’expertise des soins de santé (KCE) a étudié les avantages potentiels et les coûts liés à la chirurgie robot-assistée. Cette technologie est relativement sûre lorsqu’elle est employée par des chirurgiens expérimentés, mais on ne dispose pas encore aujourd’hui de preuves évidentes qu’elle apporte de véritables avantages par rapport à la chirurgie traditionnelle. C’est la raison pour laquelle le KCE recommande que l’INAMI ne la rembourse pas de façon inconditionnelle. Beaucoup d’hôpitaux facturent au patient ou à son assurance hospitalisation, les frais supplémentaires entraînés par la chirurgie robot-assistée. Il faudrait que, dans ce genre d’intervention, le patient soit clairement et complètement informé de l’expérience de l’équipe chirurgicale, des coûts additionnels et des alternatives possibles.
Organisatie van palliatieve zorg in België
Authors: Keirse Emmanuel , Beguin Claire , Desmedt Marianne , Deveugele Myriam , Menten Johan , Simoens, Steven  , Wens Johan , Borgermans Liesbeth , Kohn Laurence , Spinnewijn, Bram , Cardinael Ann , Kutten Betty , Vanden Berghe Paul , Paulus Dominique
Published: January 2025

Studie nr : 2007-18
Aspecifieke nekpijn
Authors: Tsakitzidis Giannoula , Remmen Roy , Peremans Lieve , Van Royen Paul , Duchesnes Christiane , Paulus Dominique , Eyssen Marijke
Published: January 2025

1 INTRODUCTION 3 -- 1 1 PURPOSE OF THE STUDY 3 -- 1 2 NON-SPECIFIC NECK PAIN: DEFINITION AND EPIDEMIOLOGY 3 -- 1 2 1 Definition 3 -- 1 2 2 Importance of neck pain 5 -- 2 METHODOLOGY 6 -- 2 1 SELECTION CRITERIA 6 -- 2 1 1 Participant 6 -- 2 1 2 Intervention 7 -- 2 1 3 Comparison 7 -- 2 1 4 Outcome 7 -- 2 2 LOCATING STUDIES 8 -- 2 2 1 Searches in databases 9 -- 2 2 2 Screening of titles and abstracts 9 -- 2 2 3 Screening full text and quality appraisal 9 -- 2 2 4 New search for diagnosis and prognosis 10 -- 2 3 DATA EXTRACTION 11 -- 3 RESULTS 12 -- 3 1 NUMBER OF PUBLICATIONS INCLUDED 12 -- 3 2 DIAGNOSIS 12 -- 3 3 ASSESSMENT OF PAIN AND DISABILITY 14 -- 3 4 PROGNOSIS 15 -- 3 5 TREATMENT 15 -- 3 5 1 Manual therapy 15 -- 3 5 2 Electrotherapy and other physical medicine modalities 19 -- 3 5 3 Multimodal interventions 20 -- 3 5 4 Multidisciplinary treatments 21 -- 3 5 5 Medication 22 -- 3 5 6 Other methods 23 -- 3 6 CLINICAL QUESTIONS ON NON-SPECIFIC NECK PAIN: SUMMARY OF THE LITERATURE FINDINGS 25 -- 3 6 1 Management of non-specific neck pain 26 -- 4 DISCUSSION 28 -- 5 SUMMARY 30 -- 6 APPENDICES 32 -- APPENDIX 1: SEARCH STRATEGY 32 -- SEARCH STRATEGY MEDLINE CLINICAL QUERIES AND SYSTEMATIC REVIEWS 32 -- SEARCH STRATEGY MEDLINE OTHERS 33 -- SEARCH STRATEGY COCHRANE 34 -- SEARCH STRATEGY PEDRO 34 -- SEARCH STRATEGY GUIDELINES 34 -- SEARCH STRATEGY EMBASE 35 -- SEARCH STRATEGY PUBMED SECOND SEARCH 36 -- SEARCH STRATEGY EMBASE 36 -- APPENDIX 2: CRITERIA USED TO ASSESS THE METHODOLOGICAL QUALITY OF -- THE STUDIES: RESULTS OF THE QUALITY APPRAISAL 37 -- QUALITY APPRAISAL: PAPERS ON DIAGNOSIS 37 -- QUALITY APPRAISAL: RCTS ON TREATMENT 38 -- QUALITY APPRAISAL: SYSTEMATIC REVIEWS 38 -- QUALITY APPRAISAL: AGREE SCORES FOR THE 2 SELECTED GUIDELINES 39 -- APPENDIX 3: EVIDENCE TABLE OF INCLUDED SYSTEMATIC REVIEWS 41 -- APPENDIX 4: EVIDENCE TABLE OF INCLUDED RCTS FOR TREATMENT 51 -- APPENDIX 5: EVIDENCE TABLE OF INCLUDED PUBLICATIONS DIAGNOSIS AND -- PROGNOSIS 55 -- APPENDIX 6: RECOMMENDATIONS COMPARED TO EXISTING GUIDELINES 57 -- APPENDIX 7 : NECK DISABILITY INDEX 60 -- ORIGINAL VERSION NECK DISABILITY INDEX: INSTRUMENT AND INTERPRETATION 60 -- DUTCH VERSION NECK DISABILITY INDEX : INSTRUMENT AND INTERPRETATION 67 -- 7 REFERENCE LIST 70
Continuïteit van de medicamenteuze behandeling tussen ziekenhuis en thuis
Authors: Spinewine Anne , Foulon Veerle , Claeys Coraline , De Lepeleire Jan , Chevalier Pierre , Desplenter Franciska , De Winter Sabrina , Dumont Christophe , Lacour Valérie , Simoens, Steven  , Dubois Cécile , Paulus Dominique
Published: January 2025

Het Federaal Kenniscentrum voor de Gezondheidszorg (KCE) onderzocht samen met apothekers en artsen van de UCL en de K.U.Leuven het effect van ziekenhuisopname en ontslag op de continuïteit van de behandeling met geneesmiddelen. Het blijkt dat de overgang van thuis naar ziekenhuis of omgekeerd, vaak zorgt voor problemen zoals onderbrekingen van de behandeling, overdoseringen, ongewenste interacties tussen geneesmiddelen, enz. Men schat dat ongeveer één op vier gehospitaliseerde patiënten hiermee wordt geconfronteerd, vooral wanneer ze terug thuis komen. Kwetsbare groepen zijn ouderen, patiënten met een psychiatrische aandoening en mensen die veel medicatie nemen. Het KCE pleit voor een nationale sensibiliseringscampagne en voor een elektronisch systeem, waardoor zorgverleners medicatiegegevens van patiënten kunnen uitwisselen.
Is Neonatale Screening op Mucoviscidose aangewezen in België?
Authors: Proesmans Marijke , Cuppens Harry , Vincent Marie-Francoise , Palem Alain , De Boeck Kris , Dierickx Kris , Nys Herman , Neyt Mattias , Vinck Imgard , Lebecque Patrick
Published: January 2025

In opdracht van het Federaal Kenniscentrum voor de Gezondheidszorg (KCE) onderzocht een team van kinderartsen, experts in neonatale screening, medisch recht en ethiek de voor- en nadelen van het systematisch testen van alle pasgeborenen op mucoviscidose. Het KCE beveelt deze screening enkel aan indien aan welbepaalde voorwaarden wordt voldaan: de toestemming van de vooraf geïnformeerde ouders, de kwaliteitsbewaking van de screeningtesten, het selectief uitvoeren van genetische testen en garanties op kwaliteitsvolle opvolging achteraf.
Optimalisatie van de werkingsprocessen van het Bijzonder Solidariteitsfonds.
Authors: Guillaume P , Moldenaers Ingrid , Bulte Steven , Debruyne Hans , Devriese Stephan , Kohn Laurence , Vinck Imgard , Piérart Julien
Published: January 2025

Het Bijzonder Solidariteitsfonds (BSF), één van de Belgische vangnetten bij hoge medische kosten, bestaat 20 jaar. Op vraag van het RIZIV bekeek het Federaal Kenniscentrum voor de Gezondheidszorg (KCE) de werking van de organisatie. Het KCE doet ook een aantal voorstellen ter verbetering: meer duidelijkheid in de voorwaarden voor tussenkomst en meer transparantie in de motivering van de beslissingen. Een centraal contactpunt bij het RIZIV voor aanvragen zou de aanvraagprocedure kunnen versnellen. Samenwerking tussen het BSF en andere instellingen, die medische behandelingen, geneesmiddelen of implantaten beoordelen en/of terugbetalen is nodig om tot een coherent terugbetalingsbeleid te komen.
Optimisation du fonctionnement du Fonds Spécial de Solidarité
Authors: Guillaume P , Moldenaers Ingrid , Bulte Steven , Debruyne Hans , Devriese Stephan , Kohn Laurence , Vinck Imgard , Piérart Julien
Published: January 2025

Le Fonds Spécial de Solidarité (FSS), un des moyens de protection des patients contre les dépenses médicales élevées, existe depuis 20 ans. A la demande de lINAMI, le Centre fédéral dexpertise des soins de santé (KCE) a examiné le fonctionnement de cet organisme, et émet un nombre de propositions damélioration : plus de clarté dans les conditions dintervention et plus de transparence dans la motivation des décisions. Un point de contact central à lINAMI pour les demandes pourrait accélérer la procédure. Une collaboration entre le FSS et les autres instances qui interviennent dans le remboursement des traitements médicaux, des médicaments ou des implants est nécessaire pour parvenir à une politique de remboursement cohérente.
Traitement endovasculaire de la sténose carotidienne
Authors: Bonneux Luc , Cleemput Irina , Ramaekers Dirk
Published: January 2025

Un des causes de l'escalade des coûts de la santé est l'apparition de technologies chères, dont il est donc important d'évaluer la valeur objective. Dans cette perspective, un rapport récent du Centre Fédéral d'Expertise des Soins de Santé (KCE) évalue la technique du "stent carotidien protégé".
Drug reimbursement systems
Authors: le Polain Maïté , Franken Margreet , Koopmanschap Marc , Cleemput Irina
Published: January 2025

LIST OF ABBREVIATIONS 3 -- 1 INTRODUCTION 5 -- 1.1 BACKGROUND 5 -- 1.2 OBJECTIVES 6 -- 1.3 METHODS AND ANALYTICAL FRAMEWORKS 6 -- 1.3.1 The description of the drug reimbursement systems 6 -- 1.3.2 Assessing accountability for reasonableness 8 -- 1.4 KEY CONCEPTS 9 -- 1.5 STRUCTURE OF THE REPORT 10 -- 2 COUNTRY COMPARISON 12 -- 2.1 CONTEXTUAL BACKGROUND 12 -- 2.1.1 Health care system characteristics 12 -- 2.1.2 Health care system and policy objectives 12 -- 2.1.3 Health care funding and pharmaceutical expenditure 13 -- 2.1.4 Pharmaceutical policies 15 -- 2.2 POLICY IMPLEMENTATION LEVEL 18 -- 2.2.1 Objectives of the drug reimbursement system. 18 -- 2.2.2 Establishment of the system 19 -- 2.2.3 Implementation: a positive reimbursement list 24 -- 2.2.4 Accountability: impact assessment 24 -- 2.3 TECHNOLOGY DECISION LEVEL 26 -- 2.3.1 Assessment and appraisal phase 26 -- 2.3.2 Decision making phase 32 -- 2.3.3 Output and Implementation 36 -- 3 DISCUSSION 39 -- 3.1 ACCOUNTABILITY FOR REASONABLENESS 39 -- 3.1.1 Transparency 40 -- 3.1.2 Relevance of the decision rationales 41 -- 3.1.3 Relevance of the decision criteria 41 -- 3.1.4 Relevance of decision criteria: summarising countries achievements 52 -- 3.1.5 Revisability 53 -- 3.1.6 Enforcement 53 -- 4 GENERAL CONCLUSIONS AND RECOMMENDATIONS 55 -- 4.1 TRANSPARENCY CONDITION 55 -- 4.2 RELEVANCE CONDITION 56 -- 4.3 REVISABILITY CONDITION 57 -- 4.4 ENFORCEMENT CONDITION 57 -- 4.5 FUTURE RESEARCH 57 -- 5 LESSONS FOR BELGIUM 60 -- 5.1 ROLES OF THE DIFFERENT ACTORS IN THE PROCESS 60 -- 5.2 STRENGTHS OF THE BELGIAN REIMBURSEMENT SYSTEM 61 -- 5.3 ISSUES RELATED TO THE DECISION PROCESS 61 -- 5.3.1 Composition of the CRM/CTG 61 -- 5.3.2 Assessment by the RIZIV/INAMI experts 62 -- 5.3.3 Appraisal by the Drug Reimbursement Committee (CRM/CTG) 63 -- 5.3.4 Price and reimbursement basis 64 -- 5.3.5 Reimbursement category 65 -- 5.3.6 Decision by the Minister 66 -- 5.4 DISCUSSION 67 -- 5.4.1 Transparency 67 -- 5.4.2 Relevance of the appraisal criteria 68 -- 5.4.3 Revisions 68 -- 5.5 CONCLUSION 68 -- 6 APPENDICES 69 -- DRUG REIMBURSEMENT SYSTEM IN AUSTRIA 69 -- DRUG REIMBURSEMENT SYSTEM IN BELGIUM 81 -- DRUG REIMBURSEMENT SYSTEM IN FRANCE 99 -- DRUG REIMBURSEMENT SYSTEM IN THE NETHERLANDS 114 -- DRUG REIMBURSEMENT SYSTEM IN SWEDEN 128 -- 7 REFERENCES 143
Stand van zaken van de homeopathie in België
Authors: De Gendt Tom , Desomer Anja , Goosens N. , Hanquet Germaine , Léonard Christian , Mertens Raf , Piérart Julien , Robays Jo , Roberfroid Dominique , Schmitz Olivier , Vinck Imgard , Kohn Laurence
Published: January 2025

1 CONTEXT 2 -- 2 DOELSTELLINGEN 2 -- 3 BEPERKINGEN 3 -- 4 HOMEOPATHIE IN BELGIË: DE GEBRUIKERS, DE BEOEFENAARS, DE -- METHODEN 4 -- 4.1 TOENEMEND BEROEP OP NIET-CONVENTIONELE GENEESWIJZEN 4 -- 4.2 WIE ZIJN DE PATIËNTEN? 4 -- 4.3 WIE ZIJN DE BEOEFENAARS? 5 -- 4.4 TYPISCH ZORGTRAJECT VAN EEN PATIËNT 6 -- 4.4.1 De sprong wagen naar alternatieve geneeswijzen 6 -- 4.4.2 De consultatie 7 -- 4.5 FINANCIËLE ASPECTEN 7 -- 4.6 WAARDERING DOOR DE PATIËNTEN 8 -- 5 IS DE WERKZAAMHEID BEWEZEN? 9 -- 5.1 DE WETENSCHAPPELIJKE LITERATUUR: GEEN ENKEL BEWIJS VAN WERKZAAMHEID 9 -- 5.2 HET STANDPUNT VAN DE PATIËNTEN 9 -- 5.3 WAT ZIJN DE RISICOS? 10 -- 6 HOE WORDT MEN HOMEOPAAT? 10 -- 7 WETTELIJK KADER 11 -- 7.1 ACHTERGROND 11 -- 7.2 DE WET COLLA 11 -- 7.3 GEVOLGEN VAN DE GEDEELTELIJKE UITVOERING VAN DE WET COLLA 13 -- 7.4 DE HOMEOPATHISCHE MIDDELEN 13 -- 8 CONCLUSIE: WAT ZIJN DE TOEKOMSTIGE UITDAGINGEN? 13 -- 9 ER IS GEEN WETENSCHAPPELIJK BEWIJS VAN KLINISCHE -- WERKZAAMHEID 14 -- 10 DE WET COLLA TOEPASSEN? 14 -- 11 DE VEILIGHEID VAN DE PATIËNTEN GARANDEREN 14 -- 12 AANBEVELINGEN 15 -- 13 REFERENTIES 15
L’oxygénothérapie à domicile
Authors: Van Meerhaeghe Alain , Annemans Lieven , Haentjens Patrick , San Miguel Lorena , Buyse Bertien , Benoit Karolien , Devriese Stephan , Stroobandt Serge , Gailly Jeannine
Published: January 2025

Des personnes souffrant de maladies pulmonaires chroniques ont parfois besoin d’un complément d’oxygène à la maison. En Belgique, ce traitement peut être prescrit sans restriction par tout médecin et l’on constate une nette augmentation des dépenses ces dernières années. Plusieurs instances de décisions sont impliquées dans l’organisation de l’oxygénothérapie, tout comme des organismes professionnels ou privés, et il y a un manque d’approche intégrée. Le Centre fédéral d’expertise des soins de santé (KCE) recommande une révision des prix et une utilisation des formes les moins chères de traitement, étant donné qu’elles ont toutes le même effet sur la santé. De plus, l’oxygénothérapie de longue durée devrait être réservée aux patients pour lesquels des preuves scientifiques montrent une amélioration liée à ce traitement: les gens avec un manque de souffle sévère dû à une BPCO, une mucoviscidose, une décompensation cardiaque ou des maladies respiratoires.
Prévention médicamenteuse des fractures ostéoporotiques
Authors: Roberfroid Dominique , Camberlin Cécile , Dubois Cécile
Published: January 2025

1 INTRODUCTION 2 -- 2 BELGIAN SITUATION ANALYSIS 4 -- 2.1 METHODS 4 -- 2.1.1 Data sources 4 -- 2.1.2 Epidemiology of fragility fractures 4 -- 2.1.3 Osteoporosis drugs consumption 5 -- 2.2 RESULTS 7 -- 2.2.1 Epidemiology of hip, humerus, vertebral and wrist fractures 7 -- 2.2.2 Utilization of osteoporosis drugs 10 -- 2.2.3 Reimbursement rules 22 -- 2.3 DISCUSSION 25 -- 3 SCREENING FOR PATIENTS AT HIGH RISK OF FRACTURES 27 -- 3.1 METHODS 27 -- 3.2 RESULTS 27 -- 3.2.1 Measuring BMD 28 -- 3.2.2 Prediction models 30 -- 3.2.3 Biochemical markers 33 -- 3.2.4 Effectiveness of screening for osteoporosis 33 -- 3.3 DISCUSSION 36 -- 4 EFFICACY OF PHARMACOLOGICAL TREATMENT 37 -- 4.1 METHODS 37 -- 4.2 RESULTS 40 -- 4.2.1 Biphosphonates 40 -- 4.2.2 Strontium ranelate 45 -- 4.2.3 Calcitonin 47 -- 4.2.4 Selective Estrogen Receptor Modulators (SERM): Raloxifene 47 -- 4.2.5 Denosumab 48 -- 4.3 DISCUSSION 48 -- 4.3.1 Influence of fracture site 48 -- 4.3.2 Influence of baseline risk 49 -- 4.3.3 Influence of treatment duration 50 -- 4.3.4 Influence of treatment type 51 -- 4.3.5 Safety issues 52 -- 5 GUIDELINES FOR OSTEOPOROSIS MANAGEMENT 54 -- 5.1 METHODS 54 -- 5.2 RESULTS 54 -- 5.3 DISCUSSION 54 -- 6 RECOMMENDATIONS 61 -- 6.1 RECOMMENDATIONS FOR CLINICIANS 61 -- 6.2 RECOMMENDATIONS FOR POLICY-MAKERS 62 -- 6.3 RECOMMENDATIONS FOR RESEARCHERS 62 -- 7 APPENDIXES 63 -- 7.1 APPENDIXES ON BELGIAN SITUATION ANALYSIS 63 -- 7.2 APPENDIXES ON SCREENING FOR OSTEOPOROSIS 93 -- 7.3 APPENDIXES ON TREATMENT EFFICACY 97 -- 8 REFERENCES 89
Quality Assurance of rectal cancer diagnosis and treatment  phase 3
Authors: Goetghebeur Els , Van Rossem Ronan , Baert Katrien , Vanhoutte Kurt , Boterberg Tom , Demetter Pieter , De Ridder Mark , Harrington David , Peeters Marc , Storme Guy , Verhulst Johanna , Vlayen Joan , Vrijens France , Vansteedlandt Stijn , Ceelen Wim
Published: January 2025

Appendix 5: Survey on the clinical importance and reliability of reporting of all QCIs discussed in the PROCARE consensus (July 2010) Appendix 6: Descriptives of the prognostic factors and QCIs and detailed results of analysis of individual QCIs Appendix 7: Accuracy and completeness of procare database Appendix 8: Further detail on the construction of adjusted excess probabilities for aggregated quality indexes
Le Burnout des médecins généralistes
Authors: Jonckheer Pascale , Stordeur Sabine , Lebeer Guy , Roland Michel , De Schampheleire Jan , De Troyer Marianne , Kacenelenbogen Nadine , Offermans Anne-Marie , Piérart Julien , Kohn Laurence
Published: January 2025

LISTE DES ABRÉVIATIONS 2 -- 1 CONTEXTE ET METHODES 4 -- 1.1 LE BURNOUT : UNE MENACE POUR LES MEDECINS GENERALISTES ET POUR LA SANTE -- PUBLIQUE 4 -- 1.2 OBJECTIFS DE LETUDE 4 -- 1.3 QUEST-CE QUE LE BURNOUT ? 5 -- 1.4 COMMENT LE KCE A-T-IL ABORDE LA PROBLEMATIQUE ? 5 -- 2 QUELS SONT LES FACTEURS ASSOCIÉS AU BURNOUT CHEZ LES -- MÉDECINS GÉNÉRALISTES ? 8 -- 3 PISTES DACTION POUR LA PRÉVENTION 9 -- 3.1 DESAMORCER LES CONFLITS DE VALEURS 10 -- 3.2 EQUILIBRER LES OBLIGATIONS ET PROTECTIONS PROFESSIONNELLES 10 -- 3.2.1 Organiser un service de santé pour les médecins généralistes 10 -- 3.2.2 Améliorer les protections sociales des médecins généralistes 11 -- 3.3 PALLIER LE MANQUE DE SUPPORT CONFRATERNEL 12 -- 3.3.1 Créer un groupe de réflexion sur le support confraternel et la compréhension mutuelle -- 12 -- 3.3.2 Poursuivre les initiatives des autorités belges concernant lencouragement à la pratique -- de groupe et à la pratique en réseau 12 -- 3.4 PALLIER LE MANQUE DE CONTROLE DU MEDECIN GENERALISTE SUR SON ACTIVITE -- PROFESSIONNELLE 13 -- 3.4.1 Soutenir les médecins généralistes dans la gestion du temps et des priorités 13 -- 3.4.2 Sensibiliser les patients afin que leurs attentes soient plus réalistes 14 -- 3.5 PALLIER LE MANQUE DE RECONNAISSANCE DE LA MEDECINE GENERALE 15 -- 3.5.1 Poursuivre les efforts assurés par les autorités publiques pour la reconnaissance du rôle -- de la médecine générale par les patients, les décideurs et les autres professionnels de la santé -- 15 -- 3.5.2 Poursuivre les efforts assurés par les autorités publiques pour une rémunération -- adéquate des médecins généralistes 15 -- 3.6 EVITER LE SURMENAGE 16 -- 3.6.1 Soutenir des mesures concrètes pour permettre de diminuer la charge administrative -- des médecins généralistes 16 -- 3.6.2 Elaborer une stratégie de soutien de la prise en charge des patientèles lourdes et des -- situations complexes 17 -- 3.6.3 Concevoir et mettre en place des services de garde bien organisés 17 -- 3.6.4 Encourager les médecins à utiliser des techniques de gestion du stress 17 -- 4 PISTES DACTION POUR LA PRISE EN CHARGE 18 -- 4.1 LE 1ER NIVEAU, UNE PORTE DENTREE AISEE ET QUI ORIENTE 18 -- 4.2 LE 2EME NIVEAU, LA COORDINATION DES SOINS 18 -- 4.3 LE 3EME NIVEAU, LE DISPOSITIF DE TRAITEMENT 19 -- 4.4 UNE FILIERE BIENVEILLANTE ET PROTEGEE 19 -- 4.5 UNE REINSERTION PROFESSIONNELLE PREPAREE 19 -- 4.6 VERS UN PROGRAMME DAIDE INTEGRALE 19 -- 5 AVANT DAGIR: QUELQUES GRANDS PRINCIPES À GARDER EN MÉMOIRE20 -- 6 RÉFÉRENCES 21
Elective care for foreign patients
Authors: De Mars Bob , Boulanger Katrien , Schoukens Paul , Sermeus Walter , Van de Voorde Carine , Vrijens France , Vinck Imgard
Published: January 2025

1. APPENDICES FROM CHAPTER 1 (INTRODUCTION) 3 -- 2. APPENDICES FROM CHAPTER 2 (LEGAL FRAMEWORK) 4 -- 3. APPENDICES FROM CHAPTER 4 (VOLUME AND CHARACTERISTICS OF FOREIGN -- PATIENTS STAYS: DATA, METHODOLOGICAL ISSUES AND RESULTS) 7 -- 3.1. APPENDICES RELATED TO MACRO DATA (HOSPITAL DISCHARGE) 7 -- 3.1.1. Description of the linkage between MCD and HBD databases 7 -- 3.1.2. Technical codes for initial selection of stays based on MCD-HBD 8 -- 3.1.3. Coding of the type of admission in MCD 9 -- 3.1.4. Selection of diagnoses and interventions in HDP-2 project 9 -- 3.1.5. Check of the selection: information available in the Maxi Feedback from SPF/FOD 10 -- 3.1.6. Volume of non residents in MCD (analyses based on country of residence) 11 -- 3.1.7. Nationality of foreign patient stays based on MCD database 11 -- 3.1.8. Nationality of coordination patients in Belgium 12 -- 3.1.9. Treatments for stays in the context of a cross-border cooperation agreement 12 -- 3.1.10. Hospitalisations for patients with foreign nationality living in Belgium 13 -- 3.1.11. Differences in severity between coordination patients and national mean for Belgian patients 15 -- 3.2. APPENDICES RELATED TO HOSPITAL REPORTS 6 -- 3.2.1. Overview of the questions from the case studies 16 -- 3.2.2. Comparison of tariffs (in euro) charged in different case study hospitals 19 -- 3.2.3. Comparison of case mix between different foreign patient flows 22
Hepatitis C: Screening en Preventie - Synthese
Authors: Gerkens Sophie , Martin Natasha , Thiry Nancy , Hulstaert Frank
Published: January 2025

Besmetting met Hepatitis C gebeurt via het bloed. Vandaag lopen vooral drugsgebruikers die injectiemateriaal delen het grootste risico op besmetting. Jaarlijks worden ongeveer 2000 nieuwe gevallen van chronische Hepatitis C vastgesteld. Deze veroorzaakt meestal geen klachten, maar op lange termijn kan zich een leverziekte ontwikkelen. Een succesvolle behandeling is mogelijk, maar minder dan de helft van de patiënten start ze ook op, wegens de lange duur en de neveneffecten. Het Federaal Kenniscentrum voor de Gezondheidszorg (KCE) beveelt een algemene opsporing van het virus niet aan, maar het testen van de risicogroepen kan wel overwogen worden. Preventieve maatregelen bij drugsgebruikers om besmetting te voorkomen, zoals het inruilen van gebruikte spuiten (spuitenruil) en het verstrekken van vervangende middelen, zoals methadon, blijken vooral HIV besmettingen te voorkomen. Hun effect op hepatitis C is minder duidelijk.
Différences géographiques de lincidence du cancer de la thyroïde en Belgique
Authors: Francart Julie , Van Den Bruel Annick , Decollonne Brigitte , Adam Marielle , Dubois Cécile , De Schutter Harlinde , Vlayen Joan , Stordeur Sabine
Published: January 2025

Lincidence des cancers de la thyroïde est deux fois plus élevée en Wallonie et à Bruxelles quen Flandre. La Ministre de la Santé Publique a demandé à lInstitut Scientifique de Santé Publique (ISP) et au Centre fédéral dexpertise des soins de santé (KCE) danalyser cette variabilité géographique, en collaboration avec la Fondation Registre du Cancer (BCR). En avril 2012, lISP a conclu que vivre aux alentours dinstallations nucléaires naugmentait pas le risque de développer un cancer de la thyroïde. Le KCE a, pour sa part, observé quà Bruxelles et plus particulièrement en Wallonie, plus dexamens dimagerie médicale et dinterventions chirurgicales sont réalisés pour le diagnostic et le traitement des pathologies de la thyroïde. Ce recours intensif augmente les chances de découvrir de manière fortuite un cancer de la thyroïde à un stade de développement précoce. Cela pourrait justifier les différences dincidence observées entre régions mais une étude approfondie reste nécessaire pour confirmer cette conclusion. Le KCE plaide pour lamélioration du suivi des recommandations internationales dans la prise en charge des pathologies thyroïdiennes. Cela contribuerait à réduire fortement les différences régionales et conduirait à une utilisation plus fréquente des procédures pré-opératoires recommandées.
Prophylactic removal of pathology-free wisdom teeth
Authors: Stordeur Sabine , Eyssen Marijke
Published: January 2025

SYNTHESIS 5 -- 1 BACKGROUND 5 -- 2 CURRENT PRACTICE IN BELGIUM 7 -- 3 SCOPE OF THIS REPORT AND METHODOLOGY 8 -- 4 CURRENT KNOWLEDGE ABOUT PROPHYLACTIC REMOVAL OF PATHOLOGYFREE THIRD MOLARS 8 -- 4.1 ORTHODONTIC INDICATIONS 8 -- 4.2 NON-ORTHODONTIC INDICATIONS 8 -- 4.3 DECISION ANALYSIS 9 -- 4.4 NEED OF WELL-BALANCED COMMUNICATION9 -- 5 CONCLUSION 9 -- 6 REFERENCES 10 -- SCIENTIFIC REPORT 11 -- 1 INTRODUCTION 11 -- 1.1 BACKGROUND11 -- 1.2 CURRENT PRACTICE IN BELGIUM 13 -- 1.2.1 NIHDI nomenclature data 13 -- 1.2.2 Data from sickness funds 13 -- 1.2.3 Data from a private insurance company 14 -- 1.2.4 The report Data Registration and Evaluation of the Oral Health of the Belgian Population 2008-2010 14 -- 1.3 SCOPE OF THIS REPORT 17 -- 2 METHODOLOGY 18 -- 2.1 GENERAL APPROACH 18 -- 2.2 LITERATURE SEARCHES 18 -- 2.2.1 Search strategy 18 -- 2.2.2 Quality appraisal 19 -- 2.2.3 Data Extraction 20 -- 3 CURRENT KNOWLEDGE ABOUT PROPHYLACTIC REMOVAL OF PATHOLOGYFREE THIRD MOLARS 20 -- 3.1 NUMBER OF RETRIEVED PUBLICATIONS 20 -- 3.1.1 Systematic reviews 20 -- 3.1.2 Health technology assessment reports 20 -- 3.1.3 Clinical practice guidelines 21 -- 3.1.4 RCTs or CCTs21 -- 3.1.5 Conclusion 21 -- 3.2 RESULTS: SYSTEMATIC REVIEWS 21 -- 3.2.1 Song et al. (2000) 21 -- 3.2.2 Mettes et al. (2005) 23 -- 3.3 RESULTS: CLINICAL PRACTICE GUIDELINE AND HTA REPORTS 24 -- 3.3.1 NICE guideline (2000) 24 -- 3.3.2 HTA report from The Canadian Agency for Drugs and Technologies in Health (2010) 24 -- 3.3.3 HTA report from the Regional HTA Centre of the Region Västra Götaland in Sweden (2010) 25 -- 3.4 DISCUSSION AND CONCLUSION 25 -- 3.4.1 Methodological quality 26 -- 3.4.2 Literature review 26 -- 3.4.3 Conclusion 26 -- APPENDICES 27 -- APPENDIX 1. 27 -- APPENDIX 1.1. NIHDI NOMENCLATURE (INAMI/RIZIV)27 -- APPENDIX 2. 38 -- APPENDIX 2.1. GRADE SYSTEM: LEVELS OF EVIDENCE 38 -- APPENDIX 2.2. AGREE INSTRUMENT (VERSION II) 39 -- APPENDIX 3. 41 -- APPENDIX 3.1. PUBMED SEARCH STRATEGY: GUIDELINES, SYSTEMATIC REVIEWS, META-ANALYSES 41 -- APPENDIX 3.2. EMBASE SEARCH STRATEGY: GUIDELINES, SYSTEMATIC REVIEWS, META-ANALYSES 42 -- APPENDIX 3.3. PUBMED SEARCH STRATEGY: RCT AND CCT 43 -- APPENDIX 3.4. EMBASE SEARCH STRATEGY: RCT AND CCT 44 -- APPENDIX 3.5. OTHER SEARCH STRATEGIES 44 -- APPENDIX 4. 45 -- APPENDIX 4.1. IDENTIFIED GUIDELINES AND THEIR QUALITY APPRAISAL (AGREE SCORE) 45 -- APPENDIX 4.2. IDENTIFIED SYSTEMATIC REVIEWS AND THEIR QUALITY APPRAISAL -- (DUTCH COCHRANE EVALUATION) 46 -- APPENDIX 4.3. EVIDENCE TABLES 50 -- APPENDIX 4.4. STAKEHOLDER MEETING 57 -- REFERENCES 60