bluuebunny/crossref_metadata_2025 huggingface dataset:
Development Content Learning System in Acid Base Solution Using Flipped Classroom at Senior High School
Authors: Gusman Elvina , Gusman Fadila , Hafizul Lathief Wirasyid
Published: June 2023

This research was conducted on developing an e-learning content using the Flipped Classroom application in chemistry subjects which is Acid base solution. The method of this research applied Research and Development (R and D) that use the 4-D model with the stages of define, design, d  evelop and disseminate. In designing this research, the author applied Thiagarajan (4D) model. In this model, 4D means define, design, develop, and disseminate. Populations in this research are students from Senior High School in West Sumatera, Indonesia. There are 10 students of SMA N 1 Rambatan, in 11 class level as respondents  for developing this product.The data sources of this study were 3 chemistry and student and teacher in Rambatan. This study applied content validity questioner as an instrument. were a content validity questionnaire, construct validity and a practicality questionnaire. This research focus on the develop stage. To analyses the data, the 4D technique is used to process the numbers of questionnaire that have been obtained from the measurement results of the questionnaire data obtained from calculations using the Aiken's V formula and a Likert scale.. The data analysis results show that the mean of Aiken's V formula and a Likert scale of content validity is 0.832 and construct validity is 0.847 with high and very high validity categories.
Validity E-Learning of Chemistry Learning Based on PjBL (Project Based Learning) Model for Thermochemistry Material with Flipped Classroom Approach for Eleventh Grade High School
Authors: Syafei Suci Sukmawati , Sausan Saniyyah , Afifah Hadistia , Efliani Efliani , Gunella Gunella
Published: June 2023

Learning using e-learning with a blended learning model using the flipped classroom method is one of the learning systems suitable for use during the Covid-19 pandemic. This research has been carried out until the validity stage by producing an e-learning based on Project Based Learning (PjBL) on Thermochemistry material by applying the flipped classroom approach in the learning process. The type of research is R&D (Research and Development), with a 4-D model consisting of: (1) define, (2) design, (3) develop, and (4) disseminate. The products produced from the study were validated by 1 Chemistry lecturer of Faculty of Mathematics and Natural Sciences UNP and 1 chemistry teacher at MAN 2 Pesisir Selatan, and continued at the revision stage based on input from the validator. The analysis of the validity test was carried out using the Cohen kappa formula. Then obtained the kappa value of content validity of 0.884 and construct validity of 0.869 with very high categories for both. Based on this, based e-learning on Project Based Learning (PjBL) for Thermochemistry material is produced by applying a valid flipped classroom approach and can be used in the learning process.
Development of Guided Inquiry-Based Flipped Classroom Learning (FGIL) on Petroleum Materials with Moodle for SMA/MA
Authors: Kamal Firmansyah Khairul , Hidayat Basultan , Riski M.
Published: June 2023

The advent of the Covid-19 pandemic has influenced many aspects of life, especially the world of education. One of them is the SMA / MA level, which allows you to activate your learning system online. Therefore, information is needed in the form of a learning system called e-learning that can support learning activities. This study aims to develop a flipped classroom (FGIL) based on guided learning of petroleum materials using Moodle for SMA / MA. This study is categorized as R & D with 4D development models. The e-learning products in this study were validated by 4 chemistry teachers, and validity and practicality test analysis were performed by 3 teachers and 10 students in SMAN 6 Padang using the VAiken formula. It was analyzed. Aiken's V-scores, obtained from the validity of the construct and the validity of the content, are 0.88 and 0.89, which is a high category. The results of practical relationships between students and teachers are in the high categories of 84.38 and 87.29, respectively. Based on the results of the data analysis, we can conclude that the content of e-learning is valid and practical to use in the learning process.
Pengaruh Financial Deepening Terhadap Pertumbuhan Ekonomi di Indonesia
Authors: Putra Valendio Allent , Irfan Muhammad
Published: June 2023

The purpose of this study is to determine the effect of Fincial Deepening on Economic Growth in Indonesia. The independent variable in this study is Findepth or the ratio of total loans to Nominal GRDP (X1) and the dependent variable is Economic Growth (Y). In this study also used control variabel, Labor or labor Force Ratio to population (X2) and Govexp variable or Ratio of government expenditure to Nominal GRDP (X3). This research is a descriptive and associative study. The data analysis used in this research is secondary data, the kind of data is panel data from 33 provinces in Indonesia from 2010-2019, the data sourced from the Central Agency for Stastistik, Indonesian Banking Statistics and Website of the Ministry of Finance of the Republic of Indonesia. The data analysis used in this research is descriptive and inductive analysis. In the inductive analysis there are several test, namely (1) Chow Test; (2) Hausman Test; (3) Panel data regression estimation test (FEM); (4) classical assumption test; (5) T test and F test. Based on the research, the result of this study is: (1) Findepth has a positive and significant effect on economic growth; (2) Labor has positive and significant effect on economic growth; (3) Govexp has a positive and significant effect on economic growth.
Dampak Kebijakan Program Pemulihan Ekonomi Nasional (PEN) Terhadap Kolektibilitas Kredit Studi Kasus : PT. Pegadaian Area Padang
Authors: Husna Rima Fauziatul , Satria Doni
Published: June 2023

This study aims to determine the effect of Customer Characteristics indicators of gender, age, education, marital status, and number of dependents, Business Characteristics indicators of business fields, ownership of business premises, length of business and monthly income, Credit Characteristics indicators of loan value, products, and the installment ratio, as well as the Characteristics of the National Economic Recovery Program (PEN) indicators of restructuring on Credit Collectibility at PT. Padang Area Padang. This research data is based on secondary data on 1,204 active customers of PT. Padang Area Padang on January 23, 2022. By using logistic regression method, the results of this study indicate that the variables of education, trade dummy, flexion dummy, installment ratio, restruk dummy , and lepas restruk dummy have a significant influence on credit collectibility at PT. Padang Area Padang
Analysis of the Opinion Students about The Online Learning System During the Pandemic Using The K-NN and Naïve Bayes Methods
Authors: Melmambessy Theovito Joseph
Published: June 2023

Abstract— Coronavirus or known as Covid-19 is an outbreak that has spread to various parts of the world including Indonesia. Residents of Ambon city also felt the difficult times of surviving in the midst of a pandemic. The adverse impact of this pandemic has notharmed the people of A mbon city, especially the lower middle class. Since the entry of this pandemic into the city of Ambon, the local government has continuously taken steps to overcome the pandemic by conducting PSBB, PPKM, and implementing various rules aimed at limiting community activities outside the home so that crowds do not occur. The negative impact due to Covid-19 also spreads to all aspects such as economic, socio-cultural, tourism aspects, and also affects the learning process in the city of Ambon, where the learning process is carried out online. This online learning process is a problem for people who do not have the supporting means to learn online. Since the Ministry of Education and Culture made this online learning decision, there have been various student opinions in response to this, especially Pattimura University students. In this study, an analysis of student opinions was carried out to find out negative sentiment, positive or neutral sentiment in students related to the online learning process policy made by the government using the K-Nearest Neighbors method and the Naïve Bayes Classifier method. in this study produced an accuracy value from the classification obtained using the KNN method was 37.12%, and the Naïve Bayes method produced a greater accuracy value of about 42.89% which was positive. This shows that the student's response to the performance and rules of online learning at one of the state universities in Ambon, Pattimura University is felt to be good for the online teaching and learning process.
Hygiene training of schoolchildren and students using the "habit trackers – checklists" technology
Authors: Milushkina OYu , Markelova SV , Ievleva OV , Skoblina NA , Khorosheva IV , Devrishov RD , Selina EG
Published: June 2023

Healthy lifestyle formation is one of the tasks of the hygiene education of children, adolescents and young adults. That is why it is necessary for educational institutions to implement the technologies focused on health preservation in students. The study was aimed to develop and test the technology for hygiene training of students. In 2017–2019 we tested the “Habit Trackers – Checklists” technology in dynamics within the framework of the hygiene training of schoolchildren in the Moscow and Astrakhan regions, and in 2021–2023 the technology was tested for college and university students. A total of 502 schoolchildren, 234 college students, and 429 university students were enrolled. In educational institutions, where the hygiene training program was implemented, the number of schoolchildren with the diseases of the musculoskeletal system and connective tissue decreased by 1.4 times, and the number of students with eye diseases decreased by 2.6 times compared to other educational institutions of the Astrakhan region. Later, when the technology was tested for college and university students, the number of students having medium and high levels of physical activity increased from 46.0% (before the hygiene training) to 72.0% (after the hygiene training). The findings allow us to recommend replicating the proposed hygiene training program in educational institutions.
Равномерная ограниченность
Authors: Казаков Илья
Published: June 2023

1) Равномерная ограниченность в точке по Коши и по Гейне

2) Эквивалетность определений Коши и Гейне

3) Критерий равномерной ограниченности
Nuevos usos del territorio, intermediación financiera y convergencia tecnológica en Argentina
Authors: Parserisas Derlis Daniela , Schiaffino Guillermo
Published: June 2023

En el periodo de la globalización las finanzas encuentran nuevas formas de expandirse en la sociedad y el territorio a partir de las modernizaciones tecnológicas contemporáneas. El uso de objetos técnicos –como los smartphones– y las plataformas digitales aceleraron la difusión de servicios y productos financieros en entornos virtuales. El objetivo del trabajo es comprender los nuevos usos del territorio y la modernización tecnológica, a partir de acciones de empresas fintech que operan fundamentalmente en medios electrónicos de pagos mediante aplicaciones móviles. La metodología empleada se basa en consultas de fuentes de información secundaria, tales como publicaciones de instituciones públicas y privadas y trabajos académicos referidos al tema, y también fuentes primarias basadas en entrevistas a informantes que trabajan en empresas de servicios informáticos y telecomunicaciones en Argentina.
Henry Dunant: rojo en la cruz
Authors: Velador González Yamel
Published: June 2023

El 17 de febrero de 2023, el Comité Internacional de la Cruz Roja cumplió 160 años. Desde 1863, dicha organización ha trabajado, guiándose por los Principios de neutralidad, imparcialidad e independencia, ayudando a las personas afectadas por los conflictos armados y otras situaciones de violencia. Qué mejor forma de conmemorar el nacimiento de dicha organización humanitaria que a través del análisis de la película Henry Dunant: Du rouge sur la croix (Henry Dunant: Rojo sobre la Cruz). Si bien, está basada en hechos reales como lo visto y vivido por Dunant en Castiglione, Italia, en la batalla de Solferino, que le da la idea para el nacimiento de lo que hoy denominamos Derecho Internacional Humanitario y del Comité Internacional de la Cruz Roja. Lo cierto es que se permite licencias novelísticas respecto de ese pasaje de la vida de Dunant, del emblema y la “primera conferencia internacional” que le daría vida al Comité y al Derecho Humanitario.
Variantes genéticas y su asociación con la rinitis alergia
Authors: Rojano Rivera Elena
Published: June 2023

La rinitis alérgica estacional afecta aproximadamente al 25 % de la población mundial. Esta patología es más común en la primavera, coincidiendo con la floración de numerosas especies vegetales, aunque también suele ocurrir en los meses de verano, finales de septiembre y octubre. Los pacientes presentan síntomas comunes, siendo los más frecuentes la congestión nasal, estornudos, tos y conjuntivitis alérgica.
Supervivencia y recuperación de descartes tras el proceso de pesca de arrastre
Authors: Barragán- Méndez Cristina , Sobrino Ignacio , Mancera Juan Miguel
Published: June 2023

Aunque ya se había considerado el estrés como un factor determinante para la supervivencia de los animales, no es hasta el año 2017 cuando estos estudios comenzaron a realizarse en España. A partir de estas premisas, surge un grupo de investigación multidisciplinar en la Universidad de Cádiz con el objetivo de establecer herramientas sólidas que estimen la supervivencia de los descartes basadas en la capacidad de recuperación de estos.
A new species of Neoseiulus Hughes (Acari: Phytoseiidae) from Karnataka, India with an identification key to Indian species of the genus
Authors: Jose Anna , Döker Ismail , Gowda Channegowda Chinnamade , Hiremath Renuka
Published: June 2023

Neoseiulus ramabettaensis n. sp. Döker and Jose is described based on specimens collected from Karnataka, India. The new species is accommodated to the cucumeris species group and ceratoni species subgroup in the genus Neoseiulus Hughes (Acari: Phytoseiidae). The morphological characters including conspicuously longer setae j1 and j3, in addition to Z4 and Z5, chelicera dentition, wider ventrianal shield at anterior corners, large crescentic preanal pores, absence of macroseta on legs II-IV, and presence of macroseta on genu I distinguished the new species from its congeners in the ceratoni species subgroup. The current study describes a macroseta on leg I (SgeI) for a species listed in the ceratoni species subgroup for the first time. Indeed, the presence of SgeI, and the absence of macroseta on leg IV are unusual characters for the genus Neoseiulus, except SgeI present in a few species in Neoseiulus desertus species group. Therefore, chaetotaxy of legs frequently used in the systematics of other groups of Mesostigmata which are closely related to the phytoseiid mites, seems to be an important morphological character and should be included in future descriptions. In addition, we constructed an identification key for the Indian species of the genus.
Two new species of the water mite genus Anisitsiellides Lundblad, 1941 from Australia (Acari: Hydrachnidia: Anisitsiellidae)
Authors: Smit Harry , Pešić Vladimir
Published: June 2023

Two new species of the genus Anisitsiellides are described from Australia. A key is provided for the Australian Anisitsiellides species. One of the new species has the dorsal shield with five pairs of glandularia, which necessitates an emendation of the diagnosis of the genus.
Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice
Authors: Yalçın Rıza , Kart Asım , Özmen Özlem , Zeybek Esra
Published: June 2023

The aim of this study was to investigate the effects of resveratrol against fumonisin B1 (FB1)-induced liver toxicity, as, to the best of our knowledge, these effects have not been investigated yet, even though the toxic effects and mechanisms of FB1 and the antioxidative effects of resveratrol are well known. 40 BALB/c mice were divided into control, FB1, resveratrol, and FB1+resveratrol groups. Control received saline for 14 days. The FB1 group received 2.25 mg/kg FB1 every other day for 14 days. The resveratrol group received 10 mg/kg resveratrol for 14 days. The FB1+resveratrol group received 2.25 mg/kg FB1 every other day and 10 mg/kg resveratrol every day for 14 days. All administrations were peritoneal. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total sialic acid (TSA) levels were analysed in serum samples, while total antioxidant status (TAS) and total oxidant status (TOS) were measured in the liver. Additionally, the liver tissue was examined for histopathological changes. AST, ALT, and TSA were significantly higher in the FB1 group than control. Resveratrol countered FB1 effects for all parameters, including TOS and TAS. Liver histology showed FB1-induced hyperaemia, infiltrations, and megalokaryosis in some hepatocytes. No pathological findings were detected in the control, resveratrol, or FB1+resveratrol group. Our findings confirm resveratrol’s protective effect against liver damage and oxidative stress caused by FB1. In addition, they suggest that increased serum TSA levels can be used as a biomarker of FB1-induced hepatotoxicity.
Implications of Money Laundering From Corruption Proceeds on The Application of Reverse Evidence in Corruption Crimes
Authors: Lindasari Lindasari
Published: June 2023

Corruption is one of the Extra Ordinary Crimes because of the difficulty of proving the crime by law enforcement. In the enforcement and eradication of corruption crimes, there are several problems faced, one of which is in settlement of corruption crimes through juridical settlement, namely the existence of an evidentiary process that is considered complex in court and as minimal as possible does not damage the protection and honor of human rights.  The United Kingdom and other European countries have used civil channels to return assets resulting from money laundering crimes, while Indonesia is still returning assets from money laundering crimes, meaning there is no return of any assets before a court decision. It takes courage from related law enforcement in the criminal act of money laundering by using the reverse burden of proof in the law of proving money laundering cases. This study aims to determine the application of reverse proof in corruption cases. This research uses normative legal research methods. The results of the study The application of reverse proof requires review because, in reverse proof, the defendant must prove that his property is not a crime of corruption. The application of the reverse proof policy is that most of the assets owned by the bribe giver are not in the name of the briber but have been suspected of money laundering to hide the original identity of the assets derived from the proceeds of corruption.
Pengaruh Kepemilikan Institusional, Ukuran Perusahaan, Dan Manajemen Aset Terhadap Nilai Perusahaan
Authors: Holly Anthony , Jao Robert , Mardiana Ana , Tangke Paulus
Published: June 2023

The purpose of study is to investigate the impact of institutional ownership, firm size, and asset management to firm value. Sample of this research is companies listed in Indonesia Stock Exchange between 2016-2018. Sample selected by purposive sampling method resulting 44 company as sample. Data type used in this study is quantitative data and analyzed using multiple regression analysis to analysis dependent variable, firm value and independent variable, institutional ownership, firm size, and asset management. The result of the research revealed institutional ownership and firm size have positive and significant effect to firm value because the mechanism of control by institutions is more effective and the bigger of the companies means their manager can accumulate value. Asset management has no effect to firm value

Keywords : Institutional Ownership, Size, Asset Management, Firm Value
"The Diplomatic Function in light of the Corona Pandemic Crisis And its Repercussions on the International System"
Authors: Abdul-Wahab Kareem Hameed  , Dr. Khalid Abood alkhafaji
Published: June 2023

The research aims to shed light on the characteristics of the diplomatic function that is the basis of the foreign policy of each country, and to study the possibility and capacity of the state in managing the crises it is going through in light of the transformations in the international system. And learn about the importance of the diplomatic function during international crises, including the Corona pandemic.

Thus, the research will address the problem of the study represented: To what extent can the diplomatic function play a prominent role in managing international crises, including the Corona pandemic and its impact on the future of the international system?

The study reached many important conclusions, including that the Corona crisis will not affect the structure of the international system in the near future, as well as the balance of power will be in the interest of the United States due to considerations of the nature of the institutional and financial system, power, hegemony and its global supremacy.

The research concluded with many recommendations, the most important of which is the need to strengthen global peace, multilateral diplomacy and international cooperation in the face of global crises.
Institute of the Financial Commissioner as a tool for resolving insurance disputes
Authors: Kovrigin Anton Aleksandrovich
Published: June 2023

The subject of the study is the specifics of legal relations arising in the sphere of functioning of the institution of the financial commissioner as an instrument for resolving insurance disputes. Due to the fact that the novelty of the Institute of the financial Commissioner has caused sufficient activity of research interest in scientific circles over the past five years, the author of this study pays attention to certain aspects not previously studied. The object of the research is the institution of the financial commissioner as a tool for resolving insurance disputes in the context of its doctrinal understanding and legal essence. Particular attention is paid to the transformation of the method of alternative settlement of insurance disputes (in foreign legal systems) into a jurisdictional institution providing mandatory pre-trial settlement. The main conclusions reached by the author are as follows. The domestic Institute of the Financial Commissioner distorts the legal nature of the institution of the financial Ombudsman, transforming an alternative way of resolving the dispute into a stage of consideration of the appeal as a mandatory pre-trial settlement. From an effective tool for resolving an insurance dispute, forming a systematic approach to resolving standard disputes and optimizing the insurance services market as a whole, the institution of a financial commissioner has been turned into a mandatory jurisdictional stage for considering insurance disputes of a certain category. The regulatory framework governing the activities of the financial Commissioner does not include professional and functional special principles of activity. Meanwhile, it is the special functional principles that determine the legal essence of the institution of state power authorized to consider appeals in any field. The conclusion is formulated about the incomplete implementation of the requirements of Federal Law No. 123-FZ, which is confirmed by the analysis of information from open sources. The main contribution of the author to the research of the topic is the analysis of the legal nature and purpose of the institution of the financial commissioner as a tool for resolving insurance disputes. The scientific novelty lies in the substantiation of the conclusion about the transformation of the institute implemented from foreign legislation into an institute with a fundamentally different purpose and content.
Knowledge regarding periodontal disease and related systemic diseases among university students: A cross-sectional study
Authors: Al Malak Ahmad , El Masri Yasmina , Haidar Cynthia , Salameh Pascale
Published: June 2023

Objectives:

Periodontal disease attained global concern especially after several studies linked periodontal disease with systemic diseases such as cardiovascular disease, diabetes mellitus, and cancer. Moreover, the prevalence of these systemic diseases among Lebanese population is considerably high. However, the knowledge regarding the periodontal health and related systemic diseases is unknown. The purpose of this questionnaire-based cross-sectional study was to examine Lebanese University students’ knowledge concerning periodontal health and related systemic diseases.

Materials and Methods:

In total, 461 students out of 520 took part between November 22, 2022, and December 1, 2022, with a 88.6% response rate and were asked to complete an online survey that included questions concerning healthy periodontium and its relation with systemic diseases.

Results:

The data revealed a poor knowledge regarding the relationship between periodontal disease and systemic diseases such as diabetes (27.5%), cardiovascular complications (28.9%), adverse pregnancy outcomes (27.5%), cancer (39.5%), respiratory problems (30.2%), and arthritis (22.1%). However, participants were aware of the healthy color and consistency of the periodontium (83.5%), (66.2%), and the need for dental check-ups (68.1%); moreover, public university and senior health-related students appeared with higher knowledge, compared with private and junior university students (P = 0.035, P = 0.048, and P < 0.001, respectively).

Conclusion:

Knowledge regarding oral health in general and periodontal health specifically must be improved among university students. Therefore, awareness campaigns must be held to increase knowledge among them and consequently among their families regarding periodontal health.
A successful long-distance relationship: How the Higher Judiciary consolidated the Sûreté Publique’s 'absolute' powers over foreigners in Belgium (1830-1914)
Authors: Feys Torsten
Published: June 2023

NL. De dienst Openbare Veiligheid (O.V.) controleerde vreemdelingen en zette ongewensten het land uit. Hiervoor rekende het op verschillende actoren, waaronder de rechterlijke macht. Dit artikel bespreekt de verhoudingen tussen beide instellingen op twee niveaus. Ten eerste, hoe hingen ze onderling van elkaar af op vlak van informatieverstrekking? Het toont aan dat correctionele rechtbanken, via informatiebulletins over vervolgde of veroordeelde vreemdelingen, een essentiële schakel vormden voor de O.V. om repressief op te treden. Omgekeerd rekenden rechtbanken niet op de O.V. om antecedenten te controleren of veroordeelden bij verstek te localiseren. Ten tweede bespreekt het artikel hoe de rechterlijke macht de bevoegdheid van de O.V. over vreemdelingen beïnvloedde. Het machtsmonopolie van de O.V. over uitwijzingen werd door lagere rechtbanken verschillende keren betwist. Deze vonnissen werden echter telkens aangevochten en uiteindelijk herroepen door het Hof van Cassatie. De analyse van de verhoudingen bewijst dat het concept « crimmigration » diepgeworteld zit in het bureaucratisch apparaat van moderne natiestaten. FR. Au cours du 19e siècle, la Sûreté Publique (S.P.) contrôlait les étrangers et expulsait les « indésirables ». Pour ce faire, elle s’appuyait sur différents acteurs, dont le système judiciaire. Cet article analyse deux aspects de la relation entre ces deux institutions. Premièrement, leur interdépendance quant à l’échange d’informations pour leur bon fonctionnement respectif. D’une part, grâce au bulletin de poursuite ou de condamnation à charge de l’étranger, les tribunaux correctionnels représentaient une source d’information clef pour la S.P., lui permettant d’agir de façon répressive. D’autre part, les tribunaux ne comptaient pas sur la S.P. pour s’informer sur les antécédents des étrangers ou de localiser des condamnés par défaut. Deuxièmement, l’article analyse à quel point le système judiciaire a influencé l’autorité de la S.P., en particulier son monopole sur les expulsions. Divers tribunaux ont contesté ce monopole, mais leurs verdicts ont été contestés à chaque fois et finalement révoqués par la Cour de cassation. L’étude de cette relation démontre que le concept de « crimmigration » est fermement enraciné dans l’apparat bureaucratique de l’État-nation moderne.
Ultra-long dendroscales of the high latitudes in North America and the high latitudes in Eurasia
Authors: Pomortsev O. A. , Kashkarov E. P. , Lovelius N. V.
Published: June 2023

Based on 7,000-year tree-ring chronologies for the Pinus aristata from the tree line of White Mountains and Great Basin of North America (Ferguson’s scale), and Larix sibirica from the polar forest edge on Yamal Peninsula (Northern Eurasia, Khantemirov’s scale) reconstructed the Holocene section from its climatic optimum to the present day. Mathematically precise global rhythm, which repeat three times on charts of dendrochronological scales with a frequency in 2,600 years, are revealed. The relationship of the stem growth with flctuations in level of the World Ocean, Caspian Sea and Arctic sea ice, as well as the development of global droughts, has been determined.

Regularities of the climate change, synchronously recorded in ultra-long dendroscales of two continents of the Northern Hemisphere by astronomically accurate rhythm in 2,600 years, most reliably reflct the Earth’s climate in recent millennia and provide the only key to its prediction in future.
Unnatural endo type-B PPAPs as novel compounds with activity against Mycobacterium tuberculosis.
Authors: Peslalz Philipp , Grieshober Mark , Kraus Frank , Bleisch Anton , Izzo Flavia , Lichtenstein Dajana , Hammer Helen , Vorbach Andreas , Momoi Kyoko , Zanger Ulrich , Brötz-Oesterhelt Heike , Braeuning Albert , Plietker Bernd , Stenger Steffen
Published: June 2023

Before the emergence of SARS-CoV-2, tuberculosis (TB) was the leading cause of infectious disease mortality worldwide. Like all antibiotic-exposed bacteria Mycobacterium tuberculosis (Mtb) developed multidrug-resistant (MDR) and exten-sively drug-resistant (XDR) strains which require new antibiotics with novel mechanism of actions. Hyperforin, a natural type-A polyprenylated polycyclic acylphloroglucinol (PPAP) isolated from St. John’s wort, is known for its antibacterial, antidepressant and antimycobacterial activity. However, hyperforin is not stable and easily degradable in light, heat it and oxidizes. Here we report photo- and benchstable type-B PPAPs with structural similarity to hyperforin and enhanced an-timycobacterial activity. We tested a panel of PPAPs and identified our previously reported molecule PPAP22 as lead compound. Converting PPAP22 into the corresponding sodium salt, PPAP53, enhanced the solubility dramatically. We show that PPAP53 inhibits the growth of virulent, extracellular Mtb. Strikingly, the activity is more pronounced intracel-lular Mtb residing in human primary macrophages without damaging the host cell or lung cells. Importantly PPAP53 was also highly active against drug-resistant Mtb. Additionally, we analysed the in vitro properties of PPAP53 in terms of CYP-induction and PXR interaction. Taken together we introduce type-B PPAPs are a new class of antimycobacterial com-pounds, with remarkable activity and favorouble physical properties.
Cannabinoid-inspired inhibitors of Autotaxin
Authors: Eymery Mathias , Nguyen Kim-Anh , Basu Shibom , Hausmann Jens , Tran-Nguyen Viet-Khoa , Seidel Hans Peter , Gutierrez Lola , Boumendjel Ahcène , McCarthy Andrew
Published: June 2023

Autotaxin (ATX) is an enzyme primarily known for the production of lysophosphatidic acid. Being involved in the development of major human diseases, such as cancer and neurodegenerative diseases, the enzyme has been featured in multiple studies as a pharmacological target. We previously found that the cannabinoid tetrahydrocannabinol (THC) could bind and act as an excellent inhibitor of ATX. This study aims to use the cannabinoid scaffold as a starting point to find cannabinoid-unrelated ATX inhibitors, following a funnel down approach in which large chemical libraries sharing chemical similarities with THC were screened to identify lead scaffold types for optimization. This approach allowed us to identify compounds bearing chromone and indole scaffolds as promising ATX inhibitors. Further optimization led to MEY-003, which is characterized by the direct linkage of an N-pentyl indole to the 5,7-dihydroxychromone moiety. This molecule has potent inhibitory activity towards ATX-β and ATX-ɣ as evidenced by enzymatic studies and its mode of action was rationalized by structural biology studies.
Multi-fidelity Bayesian Optimization of Covalent Organic Frameworks for Xenon/Krypton Separations
Authors: Gantzler Nickolas , Deshwal Aryan , Doppa Janardhan Rao , Simon Cory
Published: June 2023

Our objective is to search a large candidate set of covalent organic frameworks (COFs) for the one with the largest equilibrium adsorptive selectivity for xenon (Xe) over krypton (Kr) at room temperature. To predict the Xe/Kr selectivity of a COF structure, we have access to two molecular simulation techniques: (1) a higher-fidelity, binary grand canonical Monte Carlo simulation and (2) a lower-fidelity Henry coefficient calculation that (a) approximates the adsorbed phase as dilute and, consequently, (b) incurs a smaller computational runtime than the higher-fidelity simulation. To efficiently search for the COF with the largest high-fidelity Xe/Kr selectivity, we employ a multi-fidelity Bayesian optimization (MFBO) approach. MFBO constitutes a sequential, automated feedback loop of (1) conduct a low- or high-fidelity molecular simulation of Xe/Kr adsorption in a COF, (2) use the simulation data gathered thus far to train a surrogate model that cheaply predicts, with quantified uncertainty, the low- and high-fidelity simulated Xe/Kr selectivity of COFs from their structural/chemical features, and then (3) plan the next simulation (i.e., choose the next COF and fidelity) in consideration of balancing exploration, exploitation, and cost. We find that MFBO acquires the optimal COF among the candidate set of 609 structures using only 38 low-fidelity and nine high-fidelity simulations, incurring only 2.5%, 5% on average, and 18% on average of the computational runtime of an exhaustive, random, and single-fidelity BO search, respectively.
First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins
Authors: O'Dowd Paul , Sullivan Graeme , Rodrigues Daniel , Ní Chonghaile Tríona , Griffith Darren
Published: June 2023

The targeted degradation of proteins bound by metals represents a promising approach to treat diseases. We report the development of the first metallo-PROTAC, specifically a Pt-PROTAC, that can effectively degrade select Pt(II)-binding proteins. The reported Pt-PROTAC prototype successfully degraded thioredoxin-1 and thioredoxin reductase-1 though not glutathione-S-transferase in JJN3 and MM1.S multiple myeloma cancer cell lines. Deactivated Pt-PROTAC does not degrade thioredoxin-1 and thioredoxin reductase-1. Furthermore pretreatment of cells with the proteasome inhibitor bortezomib prevents Pt-PROTAC target degradation thereby implicating the ubiquitin proteasome system with its mode of degradation. Metallo-PROTACS will have important applications in the identification of metal binding proteins and as chemotherapeutic agents.
Stock Market Price Prediction Using Machine Learning and Deep Learning
Authors:   Assistance Professor, Department of Computer Science and Engineering, The Oxford College of Engineering, Bengaluru – 560068, Kumari Asha
Published: June 2023

This project aims to address the long-standing challenge of stock market prediction by leveraging the power of machine learning. The stock market is influenced by a multitude of factors, making it difficult for investors to accurately predict trends and make informed decisions. To mitigate this risk, we have chosen to analyse NSE real-time series data using the ARIMA model, a popular forecasting method. Our ultimate goal is to develop a user-friendly web application using Flask, which will allow investors to select a specific firm and receive a forecast for its future stock price. This application will utilize web scraping techniques to retrieve real-time data from the NSE, and the ARIMA model will be applied to predict future outcomes. By combining these powerful tools, we hope to significantly reduce the potential danger associated with stock market prediction and enable investors to make more informed decisions.
Feature Extraction Based on Cellular Particle Swarm Optimization Algorithm for American Sign Language Images
Authors:   Research Scholar, Department of Computer Science,  CMS College of Science & Commerce, Coimbatore, Tamil Nadu, India, Priya Sathiya , B Sumathi ,   Associate Professor, Department of Computer Science,  CMS College of Science & Commerce, Coimbatore, Tamil Nadu, India
Published: June 2023

Image Recognition is becoming a critical task and many problem-solving systems and approaches for image detection, analysis and classification are introduced by many modern researcher. The techniques should be user friendly and ease to interpret for both normal people and special people, it they should be analysed. The sign language act as a mode to transfer and exchange the message, information, knowledge and ideas from deaf to common people. The gaining information and responses to the pattern or gesture is called as sign. Sign Language is only mode to communication between the hearing-impaired people and common people. In this method each individual gesture is called as sign. In this system the American Sign Language recognition system which is used for visually impaired people to access and educate the special children’s. American Sign Language (ASL) images of a special people is collected with some constraints are taken as the dataset. The objective of the research work is done with three different Phase. Phase1 is pre-processing, Phase 2 is segmentation and Phase 3 is feature extraction for static hand gestures with the maximum possible accuracy rate. A novel approach for the proposed system is analysed with its structural feature extraction and compared with its parameters. The novel feature extraction is made with 8 different structural features they are Bounding Box, Area, Perimeter, Centroid, Roundness, EquiDiameter, Number of Boundaries and Angle. F-Measure, Recall and Precision based on this Accuracy, Sensitivity and Specificity are measured for features are extracted images. The accuracy of the new Phase has been found significantly higher.
Music recommender system using facial feature recognition
Authors: Harsh Mishra , Deep Kothari , Prajwal Jaiswal , Sheetal Rathi
Published: June 2023

Facial expressions convey a lot of information about the emotional state of a person and even a small change in it can help to detect changes in an individual's mood. Researchers have conducted numerous studies in the fields of machine learning and computer vision, training ML models to detect various human emotions or moods based on captured facial features. In this research, a system was proposed which is capable of identifying the user's emotions and moods and suggesting a list of appropriate songs to improve their mood. Incorporating mood detection offers significant benefits to customers' mental health and personal satisfaction. The objective of this system is to capture the user's image, detect their mood and create a music player system that recommends music based on the user's real-time mood, utilizing a web camera and deep learning algorithms.
Development of anomaly detector for motor bearing condition monitoring using Fast Fourier Transform (FFT) and Long Short Term Memory (LSTM)-Autoencoder
Authors: Sulaimon A. Bashir , Oladebo Suliat Jimoh , Idris Mohammed Kolo , Enesi Femi Aminu
Published: June 2023

Anomaly detection in motor bearings is a critical task for preventing downtime and ensuring efficient operation. This paper proposes a novel approach for anomaly detection using Fast Fourier Transform (FFT) and Long Short-Term Memory (LSTM)-Autoencoder (AE). A data processing approach based on FFT was developed to pre-process the raw sensor data. This helped to reduce noise and improve the Signal-to-Noise Ratio (SNR). Additionally, an anomaly detection model based on LSTM-Autoencoder was developed and trained on the pre-processed data. The proposed approach was able to detect anomalies at a low threshold and achieved a high accuracy score.
ATOD: A Design Investigation of Active Transport Oriented Development.
Authors:   , Racle Daniel
Published: June 2023

This research explores the relationship between active transport and density, exploring where and what housing could look like if designed with active transport users as the primary occupant in mind. This research uses Wellington, NZ, as a case study to develop design-led research answers to what an Active Transport Oriented Development (ATOD) is and how it can fit within the existing urban fabric. The toolkit contains a series of small design interventions, that can be made architecturally to medium/high-density residential buildings, to accommodate active transport users best. Active transport-oriented development should be integrated with other urban design and sustainable mobility concepts, such as the 15-minute city or Bicycle Urbanism, holistically creating more livable, sustainable and resilient urban environments.
Analysis of the Influence of Nifedipine + Magnesium Sulfate Therapy on the Clinical Effect of Pregnancy-Induced Hypertension, Renal Function, and Pregnancy Outcome
Authors: Yang Yaqin , Zhao Liping
Published: June 2023

Objective: To investigate the effect of nifedipine + magnesium sulfate treatment on pregnancy-induced hypertension. Methods: From January 2020 to January 2023, 60 patients with pregnancy-induced hypertension in our hospital were randomly divided into the control group and the observation group (30 cases in each group). The control group was treated with magnesium sulfate, while the observation group was treated with nifedipine and magnesium sulfate, and the clinical efficacy of the two groups was compared. The effective rate of treatment, blood pressure indicators, renal function indicators, adverse pregnancy outcomes, and quality-of-life scores were investigated. Results: The effective rate of treatment and quality-of-life score in the observation group were higher than those in the control group (P < 0.05). On the other hand, the diastolic and systolic blood pressure, the 24 h urine creatinine and albumin, as well as the adverse pregnancy outcomes were found to be lower in the observation group as compared to the control group (P < 0.05). Conclusion: For patients with pregnancy-induced hypertension, treatment with nifedipine and magnesium sulfate can achieve significant curative and remarkable effects. While improving blood pressure, it can also improve renal function, optimize pregnancy outcomes, and improve quality of life.
Teaching Strategy of Higher Vocational Interior Design Based on “Internet Plus” Thinking
Authors: She Linzi
Published: June 2023

“Internet Plus” thinking has been widely adopted in the teaching of interior design in colleges and universities, and its application has significant implications that cannot be disregarded. “Internet Plus” thinking not only realizes the innovation of interior design teaching but also significantly improves the level and quality of teaching. Through an analysis of the advantages of “Internet Plus” education platform and the current situation of higher vocational interior design teaching, effective strategies for higher vocational interior design teaching based on “Internet Plus” thinking are proposed in this paper in hope that this study will contribute to the efficient development of interior design teaching activities.
Increasing the static and dynamic accuracy of the parallel structure mechanism for space application
Authors: Matveev S. A. , Slobodzyan N. S. , Kiselev A. A. , Zhukov Yu. A. , Korotkov E. B.
Published: June 2023

The article considers the control system of a parallel structure mechatronic device for space application such as a hexapod (Stewart platform). The solution of the inverse problem of kinematics is described and the necessity of solving the direct problem of kinematics by numerical methods is substantiated. During the research, it was revealed that the main source of positioning errors of the hexapod without the main feedback is its linear drives, which have systematic errors in the mechanical part of the linear transmission, gearbox, in the location of the motor windings; temperature errors due to changes in the dimensions of parts due to heating or cooling; errors caused by elastic deformations under load. To improve the static accuracy of the hexapod, a number of both design and software solutions are proposed: mechanical transmission preload, individual calibration of each drive, compensation for thermal expansion, etc. To improve the dynamic accuracy, it is proposed to use the method of controlling linear drives in the servo mode along with ensuring the trajectory of the platform with the limitation of the speed of its movement and derivatives of the speed. The use of these methods makes it possible to significantly improve the accuracy of the operation of the mechanisms of a parallel structure and, thereby, to approach the achievement of the limiting qualitative properties of onboard optical-electronic and information systems of spacecraft and stations.
Implementasi Markerless Augmented Reality Pada Aplikasi Pengenalan Alat Olahraga Hockey Menggunakan Metode User Defined Target Berbasis Android
Authors: Yobella Margaretha Ekaristi , Dwi Nuryana I Kadek
Published: June 2023

Hockey merupakan salah satu olahraga yang telahdimainkan di Indonesia, namun olahraga ini masih belum cukup populer dan alat – alat olahraga hockey juga masih jarang ditemui di toko olahraga pada umumnya, untuk itu perlu dilakukan pengenalan terhadap olahraga hockey agar masyarakat tertarik untuk mulai memainkan olahraga ini. Adapun salah satu cara pengenalan olahraga ini dapat memanfaatkan teknologi augmented reality dengan demikian masyarakat dapat mengenal olahraga ini dengan efisien dan fleksibel. Salah satu metode untuk menampilkan objek augmented reality yaitu menggunakan markerless dengan teknikuser defined target. Pada aplikasi dilakukan pengujian akurasi menggunakan pertimbangkan jarak, intensitas cahaya dan target yang akan dijadikan marker. Adapun hasil dari pengujian pada sudut, aplikasi dapat menampilkan objek 3D pada target gelap dengan kontras menggunakan sudut baca minimal 0° dan maksimal 45° dan target terang dengan kontras dengan sudut baca minimal 0° dan maksimal 45°. Pada pengujian jarak, aplikasi mampu menampilkan objek 3D terhadap target gelap dengan kontras pada jarak 50 cm hingga 70 cm dan target terang dengan kontras pada jarak 50 cm hingga 70 cm. Pada pengujian intensitas cahaya, aplikasi dapat menampilkan objek 3D pada target gelap dengan kontras ketika intensitas cahaya berada pada minimal 70 lux dan maksimal 1000 lux dan target terang dengan kontras ketika intensitas cahaya berada minimal 70 lux dan maksimal 1000 lux. Berdasarkan hasil kuesioner didapatkan bahwa aplikasi ini sangat layak dengan nilai sebesar 88%.