bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1 to 4 from p53–Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT
Authors: Yang-Hartwich Yang , Tedja Roslyn , Roberts Cai M. , Goodner-Bingham Jamie , Cardenas Carlos , Gurea Marta , Sumi Natalia J. , Alvero Ayesha B. , Glackin Carlotta A. , Mor Gil
Published: April 2023

Supplementary Tables
Supplemental Tables from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2
Authors: Chen Yifan , Li Zhaomin , Dong Zizheng , Beebe Jenny , Yang Ke , Fu Liwu , Zhang Jian-Ting
Published: April 2023

Supplemental Table S1. Sequence of shRNAs and siRNAs. Supplemental Table S2. Sequences of primers for real time RT-PCR.
Supplementary Figure S1 from Toll-Like Receptor 9 Mediates CpG Oligonucleotide–Induced Cellular Invasion
Authors: Ilvesaro Joanna M. , Merrell Melinda A. , Li Li , Wakchoure Savita , Graves David , Brooks Sonja , Rahko Eeva , Jukkola-Vuorinen Arja , Vuopala Katri S. , Harris Kevin W. , Selander Katri S.
Published: April 2023

Supplementary Figure S1 from Toll-Like Receptor 9 Mediates CpG Oligonucleotide–Induced Cellular Invasion
Supplementary Table 1 from Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor
Authors: Chaudhri Virendra K. , Salzler Gregory G. , Dick Salihah A. , Buckman Melanie S. , Sordella Raffaella , Karoly Edward D. , Mohney Robert , Stiles Brendon M. , Elemento Olivier , Altorki Nasser K. , McGraw Timothy E.
Published: April 2023

XLSX file - 1691K, Supplemental Table of metabolomic data
Supplementary Figure Legends from The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion
Authors: Cheng Emily , Whitsett Timothy G. , Tran Nhan L. , Winkles Jeffrey A.
Published: April 2023

Supplementary Figure Legends
Supplementary Figure 2 from The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion
Authors: Cheng Emily , Whitsett Timothy G. , Tran Nhan L. , Winkles Jeffrey A.
Published: April 2023

Supplementary Figure 2. Effect of constitutive Src activity in NIH 3T3 cells on various intracellular signaling pathways.
Supplementary Figure 1 from The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion
Authors: Cheng Emily , Whitsett Timothy G. , Tran Nhan L. , Winkles Jeffrey A.
Published: April 2023

Supplementary Figure 1. Effect of erlotinib on p-Src levels in HCC827 cells.
Supplementary Figure 2 from Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP Model
Authors: Copeland Ben T. , Bowman Matthew J. , Ashman Leonie K.
Published: April 2023

PDF file - 297K, Characterisation of tumour lesions for expression of the neuroendocrine cell marker, synaptophysin. 5 �m FFPE sections of primary prostate tumours along with metastatic lesions in the lung and liver were characterised by indirect peroxidase IHC with the anti synaptophysin antibody (clone SY38) that labels neuroendocrine cells, as the primary antibody. Brain sections stained for neuroendocrine cells (panel A, 50 x and B 200x) show positive stained layers of the dendate gyrus indicated by the star in panel B while the arrow shows specificity as the layer is negative for synaptophysin labelling. PIN and well differentiated primary prostate tumours represented in panel C, moderately differentiated prostate tumour, represented in panel D along with liver metastatic lesion represented in panel E were negative for the labelling of synaptophysin
Supplementary Figure 6 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Authors: Javvadi Prashanthi , Makino Haruhiko , Das Amit K. , Lin Yu-Fen , Chen David J. , Chen Benjamin P. , Nirodi Chaitanya S.
Published: April 2023

PDF file - 869K, Effect of DNA-PKcs or ATM inhibition on p-T2609 in NSCLCs. h pretreatment with 10 muM NU7441 or 10 muM KU55933. Square boxes represent cropped images shown in Figure 6C
Supplementary Figures S1-S8 from An Autocrine VEGF/VEGFR2 and p38 Signaling Loop Confers Resistance to 4-Hydroxytamoxifen in MCF-7 Breast Cancer Cells
Authors: Aesoy Reidun , Sanchez Betzabe Chavez , Norum Jens Henrik , Lewensohn Rolf , Viktorsson Kristina , Linderholm Barbro
Published: April 2023

Supplementary Figures S1-S8 from An Autocrine VEGF/VEGFR2 and p38 Signaling Loop Confers Resistance to 4-Hydroxytamoxifen in MCF-7 Breast Cancer Cells
Supplementary Figure 3 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Authors: Javvadi Prashanthi , Makino Haruhiko , Das Amit K. , Lin Yu-Fen , Chen David J. , Chen Benjamin P. , Nirodi Chaitanya S.
Published: April 2023

PDF file - 729K, Proximity ligation assay (PLA): Effect of T2609A and S2056A on EGFR-DNA-PKcs binding. V3-WT DNA-PKCS, V3-S2056A and V3-T2609A CHO cells expressing wild type EGFR which were either mock-irradiated or exposed to 4 Gy IR. Left panel: representative images of nuclei (blue) and EGFR-DNA-PKcs complexes (red PLA fluorescence dots) after processing for PLA. Square boxes represent cropped images shown in Figure 5C.
Supplementary Figure 2 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Authors: Javvadi Prashanthi , Makino Haruhiko , Das Amit K. , Lin Yu-Fen , Chen David J. , Chen Benjamin P. , Nirodi Chaitanya S.
Published: April 2023

PDF file - 544K, Proximity ligation assay (PLA): Effect of DNA-Pkcs and ATM inhibition on EGFR-DNA-PKcs binding.NSCLCs or HBEC-3KT cells expressing wild type or gammaE746-E750 forms of EGFR following a 2 h pretreatment with vehicle, 10 muM NU7441 or 10 muM KU55933 were mock irradiated or exposed to 4 Gy IR and fixed at 60 minutes. Representative images of nuclei (blue) showing EGFR-DNA-PKcs complexes (intense red dots). Cropped images shown in Figure 4C
Supplementary Figure 1 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Authors: Javvadi Prashanthi , Makino Haruhiko , Das Amit K. , Lin Yu-Fen , Chen David J. , Chen Benjamin P. , Nirodi Chaitanya S.
Published: April 2023

PDF file - 286K, Alterations in ATM or DNA-PKcs do not affect IR-induced nuclear import. Deficiency or inhibition of either ATM or DNA-PKcs is associated with an absence of EGFR-DNA-PKcs binding. The data in S1A eliminate the possibility that this is due to a potential abrogation of IR-induced nuclear translocation of EGFR which could prevent access to the predominantly nuclear DNA-PKcs. (A) WB of cytosolic and nuclear fractions at indicated time-points following 4 Gy IR from V3, V3-WT DNA-PKCS and V3-7A cells(A) or AT5 and 1BR3 fibroblast cells (B) expressing wild type, L858R or gammaE746-E750 EGFR showing EGFR, cytoplasmic marker, calnexin, and nuclear marker, lamin B. With exposure to 4 Gy, wild type but not L858R or gammaE746-E750 EGFR is seen in nuclear fractions of cells that lack DNA-PKcs or ATM. (C) DNA-PKcs or ATM inhibition does not affect EGFR nuclear import. WB of cytosolic and nuclear fractions at indicated time-points following 4 Gy IR from HBEC cells expressing wild type EGFR that were pretreated for 2 hours with vehicle or DNA-PKcs inhibitor, NU7441, (top panel) or ATM inhibitor, KU55933, (bottom panel). (D) Mutant forms of EGFR are also defective in binding DNA-PKcs. The data in S1A and S1B show that IR-induced nuclear translocation is completely abrogated in L858R or gammaE746-E750 forms of EGFR, which could prevent interactions with the predominantly nuclear DNA-PKcs. Here we use in vitro binding assay to demonstrate that relative to wild type EGFR, the L858R or gammaE746-E750 are also intrinsically defective in physical association with purified DNA-PKcs. In vitro binding assay: wild type, L858R or gammaE746-E750 forms of EGFR were immuno-precipitated with anti-V5 antibody from whole cell lysates from un-irradiated HBEC cells. Lane 1 from left shows no non-specific binding to beads. Antibody-bound EGFR was thoroughly washed. Lane 2 from left shows no evidence of endogenous bound protein. Antibody bound EGFR was incubated with purified human DNA-PKcs in the presence or absence of calf thymus DNA and immuno-precipitated. DNA-PKcs was detected by western blot assay. Lane 3 and 4 show that purified DNA-PKcs physically bound wild type but not the L858R or gammaE746-E750 forms of EGFR and the binding was slightly enhanced with presence of sheared calf thymus DNA.
Supplementary Table 3 from The Proto-oncogene PKCι Regulates the Alternative Splicing of Bcl-x Pre-mRNA
Authors: Shultz Jacqueline C. , Vu Ngoc , Shultz Michael D. , Mba Mba-Uzoma U. , Shapiro Brian A. , Chalfant Charles E.
Published: April 2023

PDF file - 558K
Supplementary Table 1 from The Proto-oncogene PKCι Regulates the Alternative Splicing of Bcl-x Pre-mRNA
Authors: Shultz Jacqueline C. , Vu Ngoc , Shultz Michael D. , Mba Mba-Uzoma U. , Shapiro Brian A. , Chalfant Charles E.
Published: April 2023

PDF file - 1.7MB
Supplementary Table 1 from In Situ Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy
Authors: Gajadhar Aaron S. , Bogdanovic Elena , Muñoz Diana Marcela , Guha Abhijit
Published: April 2023

PDF file - 166K
Supplementary Figure 5 from In Situ Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy
Authors: Gajadhar Aaron S. , Bogdanovic Elena , Muñoz Diana Marcela , Guha Abhijit
Published: April 2023

PDF file - 65K
Supplementary Table 1B from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency
Authors: Moser Russell , Toyoshima Masafumi , Robinson Kristin , Gurley Kay E. , Howie Heather L. , Davison Jerry , Morgan Martin , Kemp Christopher J. , Grandori Carla
Published: April 2023

PDF file - 5.8MB
Supplementary Figure 4 from In Situ Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy
Authors: Gajadhar Aaron S. , Bogdanovic Elena , Muñoz Diana Marcela , Guha Abhijit
Published: April 2023

PDF file - 558K
Supplementary Table 1A from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency
Authors: Moser Russell , Toyoshima Masafumi , Robinson Kristin , Gurley Kay E. , Howie Heather L. , Davison Jerry , Morgan Martin , Kemp Christopher J. , Grandori Carla
Published: April 2023

PDF file - 6.3MB
Supplementary Figure 3 from In Situ Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy
Authors: Gajadhar Aaron S. , Bogdanovic Elena , Muñoz Diana Marcela , Guha Abhijit
Published: April 2023

PDF file - 141K
Supplementary Figure Legends 1-5, Table Legend 1 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency
Authors: Moser Russell , Toyoshima Masafumi , Robinson Kristin , Gurley Kay E. , Howie Heather L. , Davison Jerry , Morgan Martin , Kemp Christopher J. , Grandori Carla
Published: April 2023

PDF file - 100K
Supplementary Figure 1 from In Situ Analysis of Mutant EGFRs Prevalent in Glioblastoma Multiforme Reveals Aberrant Dimerization, Activation, and Differential Response to Anti-EGFR Targeted Therapy
Authors: Gajadhar Aaron S. , Bogdanovic Elena , Muñoz Diana Marcela , Guha Abhijit
Published: April 2023

PDF file - 125K
Supplementary Figure 4 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency
Authors: Moser Russell , Toyoshima Masafumi , Robinson Kristin , Gurley Kay E. , Howie Heather L. , Davison Jerry , Morgan Martin , Kemp Christopher J. , Grandori Carla
Published: April 2023

PDF file - 114K
Supplementary Figure 1 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency
Authors: Moser Russell , Toyoshima Masafumi , Robinson Kristin , Gurley Kay E. , Howie Heather L. , Davison Jerry , Morgan Martin , Kemp Christopher J. , Grandori Carla
Published: April 2023

PDF file - 112K
Supplementary Methods, Supplementary Figures 1-6 from Targeting RET Kinase in Neuroendocrine Prostate Cancer
Authors: VanDeusen Halena R. , Ramroop Johnny R. , Morel Katherine L. , Bae Song Yi , Sheahan Anjali V. , Sychev Zoi , Lau Nathan A. , Cheng Larry C. , Tan Victor M. , Li Zhen , Petersen Ashley , Lee John K. , Park Jung Wook , Yang Rendong , Hwang Justin H. , Coleman Ilsa , Witte Owen N. , Morrissey Colm , Corey Eva , Nelson Peter S. , Ellis Leigh , Drake Justin M.
Published: April 2023

Supplemental Figure 1. RET expression is higher in prostate cancer lines that have lost androgen receptor signaling Supplemental Figure 2. RET gene expression is higher in patient samples with pure/mixed small cell phenotype or primary NEPC and correlates with other neuroendocrine markers. Supplemental Figure 3. Knockdown of RET kinase in PC3 cells shows a modest reduction in cellular proliferation. Supplemental Figure 4. Prostate cancer cell lines show variable sensitivity to RET inhibitor treatment. Supplemental Figure 5. Organoids derived from PTEN-/- and Rb-/- prostate cells model multiple aspects of NEPC including resistance to enzalutamide treatment. Supplemental Figure 6. A higher dose replicate of AD80 treatment of NCI-H660 xenograft tumors shows a similar effect of restricting tumor growth.
Table S4 from Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600-Wild-Type Colorectal Cancer
Authors: Georgiou Alexandros , Stewart Adam , Cunningham David , Banerji Udai , Whittaker Steven R.
Published: April 2023

Table S4. STARS output to rank genes based on positive enrichment of sgRNAs in the gefitinib- versus DMSO-treated arms.
Supplementary Table 2 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Authors: Wang Huan , Wang Chao , Peng Guang , Yu Doudou , Cui Xin-Gang , Sun Ying-Hao , Ma Xiaojing
Published: April 2023

Supplementary Table 2 shows the interacting proteins of CARMIL3 identified by immunoprecipitation coupled with mass spectrometry analysis.
Table S1 from Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600-Wild-Type Colorectal Cancer
Authors: Georgiou Alexandros , Stewart Adam , Cunningham David , Banerji Udai , Whittaker Steven R.
Published: April 2023

Table S1. Details of antibodies used in this study.
Figure S7 from Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600-Wild-Type Colorectal Cancer
Authors: Georgiou Alexandros , Stewart Adam , Cunningham David , Banerji Udai , Whittaker Steven R.
Published: April 2023

Figure S7. Quantification of colony assays from Figure 5D.
Supplementary Table 1A from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Authors: Wang Huan , Wang Chao , Peng Guang , Yu Doudou , Cui Xin-Gang , Sun Ying-Hao , Ma Xiaojing
Published: April 2023

Supplementary Table 1A shows multivariate Cox regression analysis of prognostic factors of breast cancer patients (cohort TCGA-BRCA PAM50 Luminal A, N=303)
Figure S6 from Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600-Wild-Type Colorectal Cancer
Authors: Georgiou Alexandros , Stewart Adam , Cunningham David , Banerji Udai , Whittaker Steven R.
Published: April 2023

Figure S6. Loss of function PTEN mutations are associated with higher basal levels of AKT phosphorylation in a panel of KRAS-wildtype CRC cell lines.
Supplemental Materials and Methods from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Authors: Wang Huan , Wang Chao , Peng Guang , Yu Doudou , Cui Xin-Gang , Sun Ying-Hao , Ma Xiaojing
Published: April 2023

All Supplemental Materials and Methods
Figure S5 from Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600-Wild-Type Colorectal Cancer
Authors: Georgiou Alexandros , Stewart Adam , Cunningham David , Banerji Udai , Whittaker Steven R.
Published: April 2023

Figure S5. Quantification of colony assays from Figure 3D.
Figure S8 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Authors: Wang Huan , Wang Chao , Peng Guang , Yu Doudou , Cui Xin-Gang , Sun Ying-Hao , Ma Xiaojing
Published: April 2023

Supplementary Figure 8, Summary of the modality of CARMIL3 in cancer metastasis.
Figure S7 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Authors: Wang Huan , Wang Chao , Peng Guang , Yu Doudou , Cui Xin-Gang , Sun Ying-Hao , Ma Xiaojing
Published: April 2023

Supplementary Figure 7, CARMIL3 regulates β-catenin. Related to Fig. 7. A. qRT-PCR measurement of Ctnnb1 mRNA level in WT and Carmil3 KO 4T1 cells. B. HEK293T cells were transfected with CARMIL3-His or β-catenin-FLAG expressing plasmid. After 48 h, the cells were harvested for protein extraction, followed by immunoprecipitation with FLAG M2 antibody and WB. C. Correlation analysis of CARMIL3 mRNA and β-catenin protein expression with primary tumor samples of TCGA BRCA dataset, n=407, method: spearman.
Figure S3 from Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600-Wild-Type Colorectal Cancer
Authors: Georgiou Alexandros , Stewart Adam , Cunningham David , Banerji Udai , Whittaker Steven R.
Published: April 2023

Figure S3. Representation of sgRNAs targeting the 2nd, 3rd and 4th-ranked genes across the CRISPR screening arms.
Figure S6 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Authors: Wang Huan , Wang Chao , Peng Guang , Yu Doudou , Cui Xin-Gang , Sun Ying-Hao , Ma Xiaojing
Published: April 2023

Supplementary Figure 6, CARMIL3 regulates Cdh1 transcription. Related to Fig. 6. A. Result of qRT-PCR detecting mRNA level of the main Cdh1 transcriptional repressors in WT and Carmil3 KO 4T1 cells. B. WT and Carmil3 KO 4T1 cells were treated with dimethyl sulfoxide (DMSO) or gradient doses of trichostatin A (TSA) for 24 h, followed by qRT-PCR analysis, Student's t test, *** p < 0.001. C. Enrichment analysis of CARMIL3 in TCGA-BRCA (expression Z-score >1 as high, Z-score <1 as low). D. Various combination of plasmids ex-pressing CARMIL3-His (7 μg), ZEB2-FLAG (7 μg) and ubiquitin-HA (3 μg) were co-transfected into HEK293T cells. The total amount of plasmid used for transfection in every cell sample was equalized with control empty vector respectively. 48 h later, the cells were har-vested for protein extraction, followed by IP with FLAG M2 antibody and WB.
Figure S1 from Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600-Wild-Type Colorectal Cancer
Authors: Georgiou Alexandros , Stewart Adam , Cunningham David , Banerji Udai , Whittaker Steven R.
Published: April 2023

Figure S1. DIFI and DIFI-Cas9 cells exhibit equal sensitivity to EGFR inhibition.
Figure S4 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Authors: Wang Huan , Wang Chao , Peng Guang , Yu Doudou , Cui Xin-Gang , Sun Ying-Hao , Ma Xiaojing
Published: April 2023

Supplementary Figure 4, EGFP-mCARMI3 localizes at cortical plasma membrane as well as in cytoplasm. Related to Fig. 4. A. HEK293T cells were transfected with empty vector(MSCV-FLAG) or FLAG tag CAR-MIL3(MSCV-FLAG-CARMIL3), followed by immunoprecipitation (IP) with FLAG antibody and Western blot. B. Functional annotation of Gene Ontology (GO) by GeneMANIA with CARMIL3 potential interacting proteins listed is Table 1. C and D. Localization of exogenous EGFP tagged CARMIL3 in HEK293T (C) and 4T1 (D).
Figure S2 from Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
Authors: Wang Huan , Wang Chao , Peng Guang , Yu Doudou , Cui Xin-Gang , Sun Ying-Hao , Ma Xiaojing
Published: April 2023

Supplementary Figure 2, Carmil3 deficiency attenuates proliferation of tumor cells. Re-lated to Fig. 2. A and B. Carmil3 KO 4T1 tumor cell line was generated by CRISPR/Cas9 technology with a pair of sgRNA, which resulted in deleting a DNA fragment in the genomic locus of Carmil3. The targeted genomic region was amplified by PCR and sequenced (A) and the expression of Carmil3 mRNA was determined by qRT-PCR (B). C and D. Proliferation of 4T1 cells was de-termined by MTS assay (C) and BrdU incorporation assay (D). E. 4T1 WT and Carmil3 KO cells were stained with 7-aminoactinomycin D in BrdU incorporation assay, followed by FACS analysis of cell cycle. The quantified result was shown. F. At day 28 post 4T1 tumor inocula-tion, the mice were sacrificed and the primary tumor were harvested for flow cytometry analy-sis of NK1.1+ cell infiltration. The data was plotted as mean {plus minus} SEM. Statistic method: Student's t-test, * p < 0.05. The experiments were repeated three times independently.
Supplementary Table 1 from Loss of TGF-β Responsiveness in Prostate Stromal Cells Alters Chemokine Levels and Facilitates the Development of Mixed Osteoblastic/Osteolytic Bone Lesions
Authors: Li Xiaohong , Sterling Julie A. , Fan Kang-Hsien , Vessella Robert L. , Shyr Yu , Hayward Simon W. , Matrisian Lynn M. , Bhowmick Neil A.
Published: April 2023

PDF file - 62K
Supplementary Figure 2 from Loss of TGF-β Responsiveness in Prostate Stromal Cells Alters Chemokine Levels and Facilitates the Development of Mixed Osteoblastic/Osteolytic Bone Lesions
Authors: Li Xiaohong , Sterling Julie A. , Fan Kang-Hsien , Vessella Robert L. , Shyr Yu , Hayward Simon W. , Matrisian Lynn M. , Bhowmick Neil A.
Published: April 2023

PDF file - 147K
Supplementary Data from Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis
Authors: Wood Patricia A. , Yang Xiaoming , Taber Andrew , Oh Eun-Young , Ansell Christine , Ayers Stacy E. , Al-Assaad Ziad , Carnevale Kevin , Berger Franklin G. , Peña Maria Marjorette O. , Hrushesky William J.M.
Published: April 2023

Supplementary Data from Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis
Supplementary Data, Supplemental Figures 1-7 from Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
Authors: Harachi Mio , Masui Kenta , Honda Hiroaki , Muragaki Yoshihiro , Kawamata Takakazu , Cavenee Webster K. , Mischel Paul S. , Shibata Noriyuki
Published: April 2023

Figure S1. mTORC1 and mTORC2 are activated downstream of aberrant EGFR signaling in human GBM. Figure S2. mTOR complexes regulate expression of EZH2 and H3K27me3 in GBM cell lines and other types of cancer cell lines. Figure S3. EGFR activation translationally increases the level of EZH2. Figure S4. Aberrant EGFR signaling renders GBM cells sensitive to EZH2 inhibitors. Figure S5. mTORC1 regulates the expression of EZH2 translationally. Figure S6. mTORC2 regulates the production of S-adenosylmethionine (SAM). Figure S7. mTOR-dependent histone methylation epigenetically regulates tumor suppressor gene CDKN1A (p21) in GBM cells.
Supplementary Figures 1-2, Tables -12 from SINE Retrotransposons Cause Epigenetic Reprogramming of Adjacent Gene Promoters
Authors: Estécio Marcos R.H. , Gallegos Juan , Dekmezian Mhair , Lu Yue , Liang Shoudan , Issa Jean-Pierre J.
Published: April 2023

PDF file - 204K, Fig. S1. Effect of negatively oriented SINE B1 repeats on promoter activity. Fig. S2. Non-normalized luciferase readings of p14Arf, Cdkn2d and Mlh1.
Supplementary Figure 4 from RBM38 Is a Direct Transcriptional Target of E2F1 that Limits E2F1-Induced Proliferation
Authors: Feldstein Orit , Ben-Hamo Rotem , Bashari Dana , Efroni Sol , Ginsberg Doron
Published: April 2023

PDF file - 125K, Correlated expression of E2F1 and RBM38 is associated with increased survival in breast cancer patients
Supplementary Figure Legends from Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation
Authors: Kawazoe Tetsuro , Saeki Hiroshi , Oki Eiji , Oda Yoshinao , Maehara Yoshihiko , Mori Masaki , Taniguchi Koji
Published: April 2023

Supplementary Figure Legends 1-6, Supplementary Table 1
Supplementary Figure 2 from RBM38 Is a Direct Transcriptional Target of E2F1 that Limits E2F1-Induced Proliferation
Authors: Feldstein Orit , Ben-Hamo Rotem , Bashari Dana , Efroni Sol , Ginsberg Doron
Published: April 2023

PDF file - 94K, Activation of ectopic E2F1 upregulates RBM38 expression in a p53-independent manner
Supplementary Figure 6 from Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation
Authors: Kawazoe Tetsuro , Saeki Hiroshi , Oki Eiji , Oda Yoshinao , Maehara Yoshihiko , Mori Masaki , Taniguchi Koji
Published: April 2023

The effects of SFK and/or JAK inhibitors on cell proliferation-related genes in human ESCC and IHC images of tumor sections stained for YAP
Supplemental Tables 2 and 3 from Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease
Authors: Chen James L. , David Jason , Cook-Spaeth Douglas , Casey Sydney , Cohen David , Selvendiran Karuppaiyah , Bekaii-Saab Tanios , Hays John L.
Published: April 2023

GSEA analysis for all cell line datasets.
Supplemental Table 1 from Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease
Authors: Chen James L. , David Jason , Cook-Spaeth Douglas , Casey Sydney , Cohen David , Selvendiran Karuppaiyah , Bekaii-Saab Tanios , Hays John L.
Published: April 2023

HEYA8 gene signature enrichment.
Supplementary Figure 1 from Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation
Authors: Kawazoe Tetsuro , Saeki Hiroshi , Oki Eiji , Oda Yoshinao , Maehara Yoshihiko , Mori Masaki , Taniguchi Koji
Published: April 2023

IL-6 and LIF induce STAT3 nuclear translocation in human ESCC
Supplementary Tables S1-S2 from Profiling Human Androgen Receptor Mutations Reveals Treatment Effects in a Mouse Model of Prostate Cancer
Authors: O'Mahony Orla A. , Steinkamp Mara P. , Albertelli Megan A. , Brogley Michele , Rehman Haniya , Robins Diane M.
Published: April 2023

Supplementary Tables S1-S2 from Profiling Human Androgen Receptor Mutations Reveals Treatment Effects in a Mouse Model of Prostate Cancer
Supplementary Table 1 from Lung Cancer in Mice Induced by the Jaagsiekte Sheep Retrovirus Envelope Protein Is Not Maintained by Rare Cancer Stem Cells, but Tumorigenicity Does Correlate with Wnt Pathway Activation
Authors: Vaughan Andrew E. , Halbert Christine L. , Wootton Sarah K. , Miller A. Dusty
Published: April 2023

PDF file - 51KB
Supplementary Figure 3 from Lung Cancer in Mice Induced by the Jaagsiekte Sheep Retrovirus Envelope Protein Is Not Maintained by Rare Cancer Stem Cells, but Tumorigenicity Does Correlate with Wnt Pathway Activation
Authors: Vaughan Andrew E. , Halbert Christine L. , Wootton Sarah K. , Miller A. Dusty
Published: April 2023

PDF file - 196KB
Supplementary Figure 2 from Lung Cancer in Mice Induced by the Jaagsiekte Sheep Retrovirus Envelope Protein Is Not Maintained by Rare Cancer Stem Cells, but Tumorigenicity Does Correlate with Wnt Pathway Activation
Authors: Vaughan Andrew E. , Halbert Christine L. , Wootton Sarah K. , Miller A. Dusty
Published: April 2023

PDF file - 141KB
Supplementary Methods, Figures 1 - 4, Tables 1 - 2 from Targeted Inactivation of HDAC2 Restores p16INK4a Activity and Exerts Antitumor Effects on Human Gastric Cancer
Authors: Kim Jeong Kyu , Noh Ji Heon , Eun Jung Woo , Jung Kwang Hwa , Bae Hyun Jin , Shen Qingyu , Kim Min Gyu , Chang Young Gyoon , Kim Seung-Jin , Park Won Sang , Lee Jung Young , Borlak Jürgen , Nam Suk Woo
Published: April 2023

PDF file - 1223K, S1 Aberrant regulation of HDAC2 in human gastric cancer S2 Effect of HDAC2 knockdown on cell cycle distribution in MKN-1 cells S3 Western blot analysis of cell cycle regulatory proteins in MKN-1. S4 HDAC2 knockdown induces apoptosis and autophagic cell death in human gastric cancer cell line
Supplementary Figure 1 from Lung Cancer in Mice Induced by the Jaagsiekte Sheep Retrovirus Envelope Protein Is Not Maintained by Rare Cancer Stem Cells, but Tumorigenicity Does Correlate with Wnt Pathway Activation
Authors: Vaughan Andrew E. , Halbert Christine L. , Wootton Sarah K. , Miller A. Dusty
Published: April 2023

PDF file - 190KB
Supplementary Methods from The Proteasome Activator PA200 Regulates Tumor Cell Responsiveness to Glutamine and Resistance to Ionizing Radiation
Authors: Blickwedehl Jennifer , Olejniczak Scott , Cummings Ryan , Sarvaiya Nilofar , Mantilla Ana , Chanan-Khan Asher , Pandita Tej K. , Schmidt Marion , Thompson Craig B. , Bangia Naveen
Published: April 2023

PDF file - 71K
Supplementary Figures 1-2 from The Proteasome Activator PA200 Regulates Tumor Cell Responsiveness to Glutamine and Resistance to Ionizing Radiation
Authors: Blickwedehl Jennifer , Olejniczak Scott , Cummings Ryan , Sarvaiya Nilofar , Mantilla Ana , Chanan-Khan Asher , Pandita Tej K. , Schmidt Marion , Thompson Craig B. , Bangia Naveen
Published: April 2023

PDF file - 444K
Supplementary Figure S1 from TRAIL Resistance of Breast Cancer Cells Is Associated with Constitutive Endocytosis of Death Receptors 4 and 5
Authors: Zhang Yaqin , Zhang Baolin
Published: April 2023

Supplementary Figure S1 from TRAIL Resistance of Breast Cancer Cells Is Associated with Constitutive Endocytosis of Death Receptors 4 and 5
Supplementary Table 3 from Fractalkine Receptor CX3CR1 Is Expressed in Epithelial Ovarian Carcinoma Cells and Required for Motility and Adhesion to Peritoneal Mesothelial Cells
Authors: Kim Mijung , Rooper Lisa , Xie Jia , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

PDF file - 42KB
Supplementary Table 1 from Fractalkine Receptor CX3CR1 Is Expressed in Epithelial Ovarian Carcinoma Cells and Required for Motility and Adhesion to Peritoneal Mesothelial Cells
Authors: Kim Mijung , Rooper Lisa , Xie Jia , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

PDF file - 466KB
Supplementary Figure 1 from Fractalkine Receptor CX3CR1 Is Expressed in Epithelial Ovarian Carcinoma Cells and Required for Motility and Adhesion to Peritoneal Mesothelial Cells
Authors: Kim Mijung , Rooper Lisa , Xie Jia , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

PDF file - 476KB Supplementary Figure 1. CX3CR1 is expressed in multiple types of ovarian carcinoma. Brown - CX3CR1; blue - hematoxylin. Images were generated using an Aperio ScanScope digital slide scanner. Magnification - 20X. Positive cases of Krukenberg tumors (core A7), yolk sac tumors (core B3), dysgerminoma (core C4), mature teratomas (core D3), Sertoli-stromal cell tumors (core E9), granular cell tumors (core F4), thecomas (core G7), and gynandroblastomas (core H10) are presented; these cases are detailed in Supplemental Table 4.
Supplementary Figures 1-9 from The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways
Authors: Huang Jianguo , Sachdeva Mohit , Xu Eric , Robinson Timothy J. , Luo Lixia , Ma Yan , Williams Nerissa T. , Lopez Omar , Cervia Lisa D. , Yuan Fan , Qin Xiaodi , Zhang Dadong , Owzar Kouros , Gokgoz Nalan , Seto Andrew , Okada Tomoyo , Singer Samuel , Andrulis Irene L. , Wunder Jay S. , Lazar Alexander J. , Rubin Brian P. , Pipho Krista , Mello Stephano S. , Giudice Jimena , Kirsch David G.
Published: April 2023

Supplementary Figure S1. An example of measurements on a staining tissue section. Supplementary Figure S2. The Scripts used for blind analysis of the lung colonization study. Supplementary Figure S3. Example of measurements on a whole lung section. Supplementary Figure S4. All the uncropped images. Supplementary Figure S5. RNA sequencing data showing that NEAT1 is significantly upregulated in lung metastases compared to paired KP primary tumors. DESeq2 method was used for statistical analysis. Supplementary Figure S6. Expression of Neat1 in metastatic primary KP tumors and non-metastatic primary KP tumors. Supplementary Figure S7. RNA sequencing data from the Samuel Lunenfeld Research Institute showed that NEAT1 is upregulated in lung metastases compared to paired human UPS/MFS. Supplementary Figure S8. NEAT1 RNA in situ hybridization showed that the expression of NEAT1 is not significantly different in lung metastases compared to unpaired human primary UPSs. Supplementary Figure S9. Deletion of Neat1_1 region has no effect on cell proliferation in both KP and KI cell lines.
Supplementary Tables from HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells
Authors: Marhold Maximilian , Tomasich Erwin , El-Gazzar Ahmed , Heller Gerwin , Spittler Andreas , Horvat Reinhard , Krainer Michael , Horak Peter
Published: April 2023

Supplementary Tables 1-3. Supplementary Table 1. Antibodies used for FACS (pTR=primary TRAMP; TR=TRAMP-C1; DU=DU145) Supplementary Table 2. Characteristics of analyzed TRAMP mice. Supplementary Table 3. Target Forward primer Reverse primer
Supplementary Figure 8 from The p38 MAPK–MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment
Authors: de Olano Natalia , Koo Chuay-Yeng , Monteiro Lara J. , Pinto Paola H. , Gomes Ana R. , Aligue Rosa , Lam Eric W.-F.
Published: April 2023

PDF file, 1153K, Effects of p38 inhibition by SB203580 on P-JNK, P-p38, P-MKK3, P-MK2, MKP-1 and Wip1 induction by epirubicin.in U2OS cells.
Supplementary Figure 7 from The p38 MAPK–MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment
Authors: de Olano Natalia , Koo Chuay-Yeng , Monteiro Lara J. , Pinto Paola H. , Gomes Ana R. , Aligue Rosa , Lam Eric W.-F.
Published: April 2023

PDF file, 594K, Effects of expression of wild-type and a dominant negative MK2 on FOXM1 and E2F1 induction by epirubicin in JNK1/2-deficient MEFs.
Supplementary Figure 6 from The p38 MAPK–MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment
Authors: de Olano Natalia , Koo Chuay-Yeng , Monteiro Lara J. , Pinto Paola H. , Gomes Ana R. , Aligue Rosa , Lam Eric W.-F.
Published: April 2023

PDF file, 449K, Effects of p38 inhibition by SB203580 on P-JNK induction by epirubicin.
Supplementary Figure 2 from Copper Modulates Zinc Metalloproteinase-Dependent Ectodomain Shedding of Key Signaling and Adhesion Proteins and Promotes the Invasion of Prostate Cancer Epithelial Cells
Authors: Parr-Sturgess Catherine A. , Tinker Claire L. , Hart Claire A. , Brown Michael D. , Clarke Noel W. , Parkin Edward T.
Published: April 2023

PDF file - 87K, The Jagged1 ectodomain generated in the presence of copper is smaller than constitutively-generated sJag
Supplementary Figure 5 from The p38 MAPK–MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment
Authors: de Olano Natalia , Koo Chuay-Yeng , Monteiro Lara J. , Pinto Paola H. , Gomes Ana R. , Aligue Rosa , Lam Eric W.-F.
Published: April 2023

PDF file, 1318K, Effects of p38α and E2F1 knockdown on P-E2F1, E2F1 and FOXM1 induction in response to epirubicin in U2OS cells.
Supplementary Figure 4 from The p38 MAPK–MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment
Authors: de Olano Natalia , Koo Chuay-Yeng , Monteiro Lara J. , Pinto Paola H. , Gomes Ana R. , Aligue Rosa , Lam Eric W.-F.
Published: April 2023

PDF file, 686K, Effects of p38α knockdown on P-E2F1, E2F1 and FOXM1 induction in response to epirubicin in MCF-7 and MCF-7EpiR cells.
Supplementary Figure 3 from The p38 MAPK–MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment
Authors: de Olano Natalia , Koo Chuay-Yeng , Monteiro Lara J. , Pinto Paola H. , Gomes Ana R. , Aligue Rosa , Lam Eric W.-F.
Published: April 2023

PDF file, 783K, Effects of p38 inhibition by SB203580 on P-JNK induction by epirubicin.
Supplementary Methods, Figures 1-5, Tables 1-4 from STEAP1 Is Associated with the Invasive and Oxidative Stress Phenotype of Ewing Tumors
Authors: Grunewald Thomas G.P. , Diebold Isabel , Esposito Irene , Plehm Stephanie , Hauer Kristina , Thiel Uwe , da Silva-Buttkus Patricia , Neff Frauke , Unland Rebekka , Müller-Tidow Carsten , Zobywalski Colette , Lohrig Katharina , Lewandrowski Urs , Sickmann Albert , da Costa Olivia Prazeres , Görlach Agnes , Cossarizza Andrea , Butt Elke , Richter Günther H.S. , Burdach Stefan
Published: April 2023

PDF file - 621K
Supplementary Figure 2 from The p38 MAPK–MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment
Authors: de Olano Natalia , Koo Chuay-Yeng , Monteiro Lara J. , Pinto Paola H. , Gomes Ana R. , Aligue Rosa , Lam Eric W.-F.
Published: April 2023

PDF file, 933K, Effects of Chk2 and/or MK2 knockdown on P-E2F1, E2F1 and FOXM1 protein expression.
Supplementary Table 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Authors: Chiappinelli Katherine B. , Haynes Brian C. , Brent Michael R. , Goodfellow Paul J.
Published: April 2023

XLS file - 10K
Supplementary Methods and Materials, Tables 1-2 from α-Catulin Marks the Invasion Front of Squamous Cell Carcinoma and Is Important for Tumor Cell Metastasis
Authors: Cao Christine , Chen Yibu , Masood Rizwan , Sinha Uttam K. , Kobielak Agnieszka
Published: April 2023

PDF file - 84K
Supplementary Figure 3 from α-Catulin Marks the Invasion Front of Squamous Cell Carcinoma and Is Important for Tumor Cell Metastasis
Authors: Cao Christine , Chen Yibu , Masood Rizwan , Sinha Uttam K. , Kobielak Agnieszka
Published: April 2023

PDF file - 48K, A, performing a cell growth assay, it was observed that the knockdown of �-catulin does not affect cell growth in USC-HN1 cells. B, AnnexinV analysis was performed to look at cell apoptosis. Cells were either left untreated or treated with TNF-� (10ng/mL) and CHX (10�g/mL) for 30 hrs to induce apoptosis. There was no considerable difference in apoptosis between the control and �-catulin knockdown USC-HN1 cells, either untreated or treated with TNF-� and CHX. One representative experimental result is shown
Supplementary Figure 5 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Authors: Chiappinelli Katherine B. , Haynes Brian C. , Brent Michael R. , Goodfellow Paul J.
Published: April 2023

PDF file - 79K
Supplementary Figure 2 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Authors: Chiappinelli Katherine B. , Haynes Brian C. , Brent Michael R. , Goodfellow Paul J.
Published: April 2023

PDF file - 62K
Supplementary Table 2 from Impaired Long-Term Expansion and Self-Renewal Potential of Pediatric Acute Myeloid Leukemia–Initiating Cells By PTK787/ZK 222584
Authors: Weidenaar Alida C. , ter Elst Arja , Kampen Kim R. , Meeuwsen-de Boer Tiny , Kamps Willem A. , Schuringa Jan Jacob , de Bont Eveline S.J.M.
Published: April 2023

XLSX file - 32K, Phosphorylation of downstream intracellular kinases.
Supplementary Figure 1 from Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Authors: Chiappinelli Katherine B. , Haynes Brian C. , Brent Michael R. , Goodfellow Paul J.
Published: April 2023

PDF file - 46K
Supplementary Figure Legend from Impaired Long-Term Expansion and Self-Renewal Potential of Pediatric Acute Myeloid Leukemia–Initiating Cells By PTK787/ZK 222584
Authors: Weidenaar Alida C. , ter Elst Arja , Kampen Kim R. , Meeuwsen-de Boer Tiny , Kamps Willem A. , Schuringa Jan Jacob , de Bont Eveline S.J.M.
Published: April 2023

PDF file - 85K
Supplementary Figures S1-S3 from Opposing Roles of c-Jun NH2-Terminal Kinase and p38 Mitogen-Activated Protein Kinase in the Cellular Response to Ionizing Radiation in Human Cervical Cancer Cells
Authors: Kim Min-Jung , Choi Soon-Young , Park In-Chul , Hwang Sang-Gu , Kim Changil , Choi Young-Hyun , Kim Haekwon , Lee Kee-Ho , Lee Su-Jae
Published: April 2023

Supplementary Figures S1-S3 from Opposing Roles of c-Jun NH2-Terminal Kinase and p38 Mitogen-Activated Protein Kinase in the Cellular Response to Ionizing Radiation in Human Cervical Cancer Cells
Supplementary Figure 2 from Impaired Long-Term Expansion and Self-Renewal Potential of Pediatric Acute Myeloid Leukemia–Initiating Cells By PTK787/ZK 222584
Authors: Weidenaar Alida C. , ter Elst Arja , Kampen Kim R. , Meeuwsen-de Boer Tiny , Kamps Willem A. , Schuringa Jan Jacob , de Bont Eveline S.J.M.
Published: April 2023

PDF file - 147K, Effect of VEGFA-addition, Bevacizumab, specific VEGFR-inhibitor and MK2206 on CD34+ sorted pediatric AML cells.
Supplementary Figure 1 from Impaired Long-Term Expansion and Self-Renewal Potential of Pediatric Acute Myeloid Leukemia–Initiating Cells By PTK787/ZK 222584
Authors: Weidenaar Alida C. , ter Elst Arja , Kampen Kim R. , Meeuwsen-de Boer Tiny , Kamps Willem A. , Schuringa Jan Jacob , de Bont Eveline S.J.M.
Published: April 2023

PDF file - 161K, Effect of PTK787/ZK 222584 and MK2206 on AML cell lines.
Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Authors: Zhan Yang , Zhang Guanyi , Wang Xiaojie , Qi Yanfeng , Bai Shanshan , Li Dongying , Ma Tianfang , Sartor Oliver , Flemington Erik K. , Zhang Haitao , Lee Peng , Dong Yan
Published: April 2023

Supplementary Figure Legends
Supplementary Figure 8 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

SOX9 regulates cell apoptosis in TNBC cells but not in non-TNBC cells
Supplementary Figure 5 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Authors: Zhan Yang , Zhang Guanyi , Wang Xiaojie , Qi Yanfeng , Bai Shanshan , Li Dongying , Ma Tianfang , Sartor Oliver , Flemington Erik K. , Zhang Haitao , Lee Peng , Dong Yan
Published: April 2023

S5. AR-V1 dimerizes with AR-V7 and AR-FL.
Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Authors: Zhan Yang , Zhang Guanyi , Wang Xiaojie , Qi Yanfeng , Bai Shanshan , Li Dongying , Ma Tianfang , Sartor Oliver , Flemington Erik K. , Zhang Haitao , Lee Peng , Dong Yan
Published: April 2023

S4. Confocal fluorescence microscopy of AR-V1 and AR-V7 subcellular localization when expressed alone.
Supplementary Figure 5 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

The association between SOX9 expression and overall survival or Metastasis-Free Survival in breast cancer patients
Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Authors: Zhan Yang , Zhang Guanyi , Wang Xiaojie , Qi Yanfeng , Bai Shanshan , Li Dongying , Ma Tianfang , Sartor Oliver , Flemington Erik K. , Zhang Haitao , Lee Peng , Dong Yan
Published: April 2023

S2. AR-V4/V6 nuclear translocation leads to induced AR transactivation in C4-2 cells.
Supplementary Figure 4 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

Expression of SOX9 in Curtis breast cancer dataset and NEVE breast cancer cell lines
Supplementary Figure 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Authors: Zhan Yang , Zhang Guanyi , Wang Xiaojie , Qi Yanfeng , Bai Shanshan , Li Dongying , Ma Tianfang , Sartor Oliver , Flemington Erik K. , Zhang Haitao , Lee Peng , Dong Yan
Published: April 2023

S1. Schematic representation of the structure of AR-FL and AR-V transcripts and proteins.
Supplementary Figure 16 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

H3k27AC/Me3 binding peaks in the promoter area of SOX9 targets
Supplementary Figure 15 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

SOX9 binding peaks in the promoter area of EMT factors
Supplementary Table Legends 1-2 from Human ESC Self-renewal Promoting microRNAs Induce Epithelial–Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways
Authors: Jung Christine J. , Iyengar Sushma , Blahnik Kimberly R. , Jiang Joy X. , Tahimic Candice , Torok Natalie J. , de vere White Ralph W. , Farnham Peggy J. , Zern Mark
Published: April 2023

PDF file - 59K
Supplementary Figure 14 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

SOX9 binding peaks in the promoter area of apoptosis factors (2)
Supplementary Table 1 from Human ESC Self-renewal Promoting microRNAs Induce Epithelial–Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways
Authors: Jung Christine J. , Iyengar Sushma , Blahnik Kimberly R. , Jiang Joy X. , Tahimic Candice , Torok Natalie J. , de vere White Ralph W. , Farnham Peggy J. , Zern Mark
Published: April 2023

XLS file - 42K, KEGG Pathway Categories of Differentially Up-Regulated Genes Following EHCC miRNA Expression in hPHs
Supplementary Figure Legends 1-6 from Human ESC Self-renewal Promoting microRNAs Induce Epithelial–Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways
Authors: Jung Christine J. , Iyengar Sushma , Blahnik Kimberly R. , Jiang Joy X. , Tahimic Candice , Torok Natalie J. , de vere White Ralph W. , Farnham Peggy J. , Zern Mark
Published: April 2023

PDF file - 12K
Supplementary Figures S1-S8 from Notch Inhibits Expression of the Krüppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium
Authors: Ghaleb Amr M. , Aggarwal Gaurav , Bialkowska Agnieszka B. , Nandan Mandayam O. , Yang Vincent W.
Published: April 2023

Supplementary Figures S1-S8 from Notch Inhibits Expression of the Krüppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium
Supplementary Figure 1 - Part 2 from SOX9 Is Essential for Triple-Negative Breast Cancer Cell Survival and Metastasis
Authors: Ma Yanxia , Shepherd Jonathan , Zhao Dekuang , Bollu Lakshmi Reddy , Tahaney William M. , Hill Jamal , Zhang Yun , Mazumdar Abhijit , Brown Powel H.
Published: April 2023

The association of SOX transcription factors expression level and breast cancer subtypes IN Esserman dataset
Supplemental Table 2 from The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer
Authors: Luo Leo Y. , Kim Eejung , Cheung Hiu Wing , Weir Barbara A. , Dunn Gavin P. , Shen Rhine R. , Hahn William C.
Published: April 2023

Supplemental Table 2. List of genes contained in genomic region 12q15 (chr12: 69692322-71120515) that are recurrently amplified in high-grade serous ovarian cancers.
Supplemental Table 1 from The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer
Authors: Luo Leo Y. , Kim Eejung , Cheung Hiu Wing , Weir Barbara A. , Dunn Gavin P. , Shen Rhine R. , Hahn William C.
Published: April 2023

Supplemental Table 1. List of 50 genes that are specifically essential and amplified in ovarian cancer.
Supplemental Figure 2 from The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer
Authors: Luo Leo Y. , Kim Eejung , Cheung Hiu Wing , Weir Barbara A. , Dunn Gavin P. , Shen Rhine R. , Hahn William C.
Published: April 2023

Supplemental Figure 2. FRS2 suppression induces apoptosis in FRS2 amplified cell lines, shown by propidium iodide staining and flow cytometry.