bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges and opportunities in building critical health literacy
Authors: Sykes Susie , Wills Jane
Published: November 2018

Background:

Critical health literacy is the least explored domain of health literacy and is addressed by few projects seeking to build health literacy. Lack of research means there is little evidence upon which to design effective interventions. Yet critical health literacy offers potential for individuals and communities to make important contributions to their own and society’s health. This paper reports on an evaluation of a community project designed to develop critical health literacy.

Method:

The evaluation explored, (a) processes used to build critical health literacy and (b) the impact on the critical health literacy of participants. A mixed methods approach was used combining a pre-and post-intervention assessment of 14 of the 24 participants using the All Aspects of Health Literacy Scale, with participant focus groups and facilitator interviews.

Results:

Strategies used to build critical health literacy included informal and participatory learning, supported and independent assessment of the problem, appraising information, familiarisation of health systems and services, and social support. Common to these was learning within the context of participants’ lives. Fewer strategies encouraged empowerment and political action. The evaluation showed slight improvements in some critical health literacy competencies: the ability to critically appraise health information and apply it to the context of their own lives and being able to critically question health professionals based on an individual’s own research. However, there was no change in participants’ ability to understand the determinants of health or involvement in activities for social and political change.

Conclusion:

Informal, participatory community projects can successfully build many characteristics of critical health literacy. However, the political action element of critical health literacy remains the least well understood and faces particular challenges in its implementation.
Timing of Open Reduction and Internal Fixation of Ankle Fractures
Authors: Tantigate Direk , Ho Gavin , Kirschenbaum Joshua , Bäcker Henrik , Asherman Benjamin , Freibott Christina , Greisberg Justin K. , Vosseller J. Turner
Published: November 2018

Background. Unstable ankle fractures are treated with open reduction internal fixation (ORIF) to prevent posttraumatic arthritis. Typically, ORIF is performed as an ambulatory surgery several days to a few weeks after injury. It is unclear what effect this delay may have on functional outcome. This study aimed to assess the effect of timing of ankle ORIF on wound complications and functional outcome. Methods. A retrospective review of 121 patients who underwent ankle ORIF was performed. A total of 58 patients had a follow-up of at least 24 months. Time between injury and surgery greater than 14 days was defined as “delayed.” Demographic variables, injury characteristics, length of surgery, and postoperative stay were documented. Comparison of demographic variables, wound complications, and functional outcome determined by Foot and Ankle Outcome Score (FAOS) was performed. Results. 118 patients were included. The duration between injury and surgery was 6 days in the “early” group and 19 days in the “delayed” group. There were no significant differences in demographic variables, injury characteristics, and length of surgery between the groups. Wound complications in the early and delayed groups were 5% and 11.8%, although this difference was not statistically significant. Among 58 patients who had a follow-up of at least 24 months, the median follow-up time was 38 (range, 24-76) months. Each subscale of FAOS demonstrated no significant difference. Conclusion. Ankle ORIF more than 14 days after injury did not significantly increase the rate of wound complication, nor did it impair ultimate functional outcome in this group.

Levels of Evidence: Level III
Attainment of lipid goals and long-term mortality after coronary-artery bypass surgery
Authors: Zafrir Barak , Saliba Walid , Jaffe Ronen , Sliman Hussein , Flugelman Moshe Y , Sharoni Erez
Published: November 2018

Introduction

There is paucity of data regarding lipid goal attainment after coronary-artery bypass graft surgery (CABG) and its impact on adverse outcomes. We aimed to investigate the attainment of lipid goals and the association between plasma lipid levels achieved after CABG and mortality.

Methods

Retrospective analysis of 1230 patients undergoing CABG. Mortality was examined in relation to most-recent lipid levels attained, categorized by clinically-relevant thresholds, and according to the improvement from pre-operative levels.

Results

Low-density lipoprotein cholesterol (LDL-C) < 70 mg/dL was attained by 44% of the patients. After multivariable adjustment, the hazard ratio for long-term mortality was 1.33 (95% confidence interval, 1.05–1.67) and 1.97 (1.55–2.50) for patients attaining LDL-C 70–100 mg/dL and >100 mg/dL, respectively, compared with LDL-C < 70 mg/dL. The hazard ratio was 1.42 (1.07–1.88) and 1.73 (1.33–2.23) for patients attaining high-density lipoprotein cholesterol (HDL-C) 40–50 mg/dL and <40 mg/dL, respectively, compared with HDL-C > 50 mg/dL; and 1.11 (0.85–1.45) and 4.28 (1.89–9.68) for patients with triglycerides 200–500 mg/dL and >500 mg/dL compared with triglycerides <200 mg/dL. A progressive stepwise association was seen between the cumulative status of the lipid measures achieved and long-term mortality, with the lowest risk observed in those with optimal level of all lipid measures ( p < 0.0001). Improvement in any of the lipid measures from pre-operative to latest documented levels was associated with reduced mortality.

Conclusions

Lack of attainment of optimal levels of routine lipid measures after CABG was common and associated both independently and additively with long-term mortality, emphasizing the importance of addressing plasma lipid profile as both a risk marker and a treatment target after CABG.
Fractionally Cointegrated Vector Autoregression Model: Evaluation of High/Low and Close/Open Spreads for Precious Metals
Authors: Gunay Samet
Published: November 2018

Daily high/low and close/open prices are the key parameters of candlestick approach in technical analysis. Besides, the price spreads are also important as they represent an upward or a downward trend. In this study, we investigate the relationship between daily high/low prices and close/open prices for precious metals: gold, copper, palladium, and silver. Empirical analysis has been performed through fractionally cointegrated vector autoregression (FCVAR) model. To observe the relationships, the trends are tested for their characteristics in both states: positive and negative spreads in close/open prices. Results indicated that for a positive trend, high/low spreads have a negative impact on close/open spreads in long run relationship. However, when closing price is less than the opening prices, it is revealed that expanding range in high/low spreads causes a rise in close/open spreads for copper and silver differently from gold price.
Quantitative Analysis of Heterogeneity in Academic Achievement of Children With Autism
Authors: Chen Lang , Abrams Daniel A. , Rosenberg-Lee Miriam , Iuculano Teresa , Wakeman Holly N. , Prathap Sandhya , Chen Tianwen , Menon Vinod
Published: November 2018

Autism spectrum disorders (ASD) represent a quintessential example of a clinical population with diverse symptom presentations and marked variation in cognitive abilities. However, the extensive literature lacks rigorous quantitative procedures for characterizing heterogeneity of cognitive abilities in these individuals. Here we employ novel clustering and cross-validation procedures to investigate the stability of heterogeneous patterns of cognitive abilities in reading and math in a relatively large sample ( N = 114) of children with ASD and matched controls ( N = 96). Our analysis revealed a unique profile of heterogeneity in ASD, consisting of a low-achieving subgroup with poor math skills compared with reading and a high-achieving subgroup who showed superior math skills compared with reading. Verbal and central executive working memory skills further differentiated these subgroups. Findings provide insights into distinct profiles of academic achievement in children with ASD, with implications for educational practice and intervention, and provide a novel framework for quantifying heterogeneity in the disorder.
Pubertal Timing as a Transdiagnostic Risk for Psychopathology in Youth
Authors: Hamlat Elissa J. , Snyder Hannah R. , Young Jami F. , Hankin Benjamin L.
Published: November 2018

Evidence suggests that early pubertal timing may operate as a transdiagnostic risk factor (i.e., shared across syndromes of psychopathology) for both genders. The current study examined associations between pubertal timing and dimensional psychopathology, structured across different levels of three organizational models: (a) DSM-based syndrome model, (b) traditional model of internalizing and externalizing factors, and (c) bifactor (p factor) model, which includes a general psychopathology factor as well as internalizing- and externalizing-specific factors. For study analyses, 567 youth-parent pairs completed psychopathology measures when youths (55.5% female) were 13.58 years old ( SD = 2.37, range = 9–17 years). Findings across all models revealed that early pubertal timing served as a transdiagnostic risk factor and also displayed some syndrome-specific associations. Gender did not moderate any relationships between pubertal timing and psychopathology. Study findings reinforce the importance of examining risk across different levels of psychopathology conceptualization and analysis.
Wells Fargo: Fall from Great to Miserable: A Case Study on Corporate Governance Failures
Authors: Veetikazhi Ramachandran , Krishnan Gopinath
Published: November 2018

This case study examines corporate governance issues at Wells Fargo and Company. The bank was embroiled in controversies due to its cross-selling tactics and the enormous pressure the management exerted on the employees to ensure its success. Investigations by media, followed by statutory agencies, revealed the creation of fake accounts without the knowledge of the customers, sometimes forging their signatures. The CEO of the bank had to resign after facing a hostile US Senate Banking Committee hearing. Wells Fargo had to pay a fine of USD185 million to various statutory agencies. The board used clawback provisions on the CEO and the head of Community Bank. The latter was held responsible for the audacious sales culture which resulted in sales integrity issues. Wells Fargo seemed to have a perfect board, a lead director and a much acclaimed CEO, apart from seven board committees. External auditors were one of the ‘big fours’. This case is intended to stimulate discussion in the class on why corporate governance practices fail, despite a seemingly healthy governing structure.
Exposure to Adverse Childhood Experiences and Oral Health Measures in Adulthood: Findings from the 2010 Behavioral Risk Factor Surveillance System
Authors: Akinkugbe A.A. , Hood K.B. , Brickhouse T.H.
Published: November 2018

Introduction:

Adverse childhood experiences (ACEs) are negative life events occurring before the age of 18 y. ACEs are risk factors for heart disease and diabetes in adult life. Furthermore, individuals who experience ACEs are more likely to smoke and become obese—factors associated with poor oral health.

Objective:

This study investigated likely associations between ACEs and the oral health measures of the 2010 Behavioral Risk Factor Surveillance System (BRFSS).

Methods:

Data from 16,354 participants of the 2010 BRFSS were analyzed with SAS 9.4. ACE scores were calculated in 2 domains: abuse (emotional, physical, or sexual) and household challenges (parental separation or divorce, intimate partner violence, household substance abuse, household mental illness, and incarceration). ACE scores, ranging from 0 to 8, were categorized into 0, 1, 2, 3, and ≥4. The 2010 BRFSS oral health measures included >1 y since last dental visit, ≥6 teeth extracted, and ≥2 y since last dental cleaning. Survey logistic regression estimated prevalence odds ratios and 95% CIs, adjusted for age, sex, race/ethnicity, and educational attainment.

Results:

The weighted mean ACE score was 1.74 (95% CI = 1.68 to 1.81), and the weighted and age-standardized percentages of study participants with ACE scores of 0, 1, 2, 3, and ≥4 were 33.1%, 24.3%, 14.9%, 9.69%, and 18.1%, respectively. There appeared to be a dose-response association between categories of ACE scores and the oral health measures. Specifically, when compared with participants with an ACE score of 0, participants with ACE scores of 1, 2, 3, and ≥4 had adjusted prevalence odds ratios (95% CIs) of 1.10 (0.82 to 1.47), 1.20 (0.90 to 1.60), 1.35 (0.98 to 1.85), and 1.72 (1.31 to 2.26), respectively, for reporting ≥2 y since last dental cleaning.

Conclusions:

Findings suggest that ACEs may be associated with poor oral health measures in adulthood, even after adjusting for important oral diseases risk factors. Longitudinal follow-up studies are needed to delineate pathways by which this relationship occurs.

Knowledge Transfer Statement:

Our findings indicate that exposure to childhood trauma may have negative impacts on oral health in adulthood. Oral health practitioners need to be aware of the potential impacts of childhood trauma on health behaviors that ultimately affect oral health outcomes.
Reliability of a multi‐segment foot model in a neutral cushioning shoe during treadmill walking
Authors: Balsdon Megan E. R. , Dombroski Colin E.
Published: November 2018

Background

Detailed kinematics of the foot has been frequently reported on in the literature, specifically using various multi‐segment foot models. It is important to identify the reliability of a multi‐segment foot model in a population of mixed genders and activity levels, while walking in commonly used footwear. The main objective of this study was to investigate the between‐day reliability and within‐session variability of the Oxford Foot Model (OFM) while walking in a neutral cushioning shoe.

Methods

A 7‐camera Vicon motion capture system was used along with 29 passive reflective markers, placed on the participant to examine the multi‐segment foot kinematics of the left foot using the OFM. Windows were cut in New Balance 840 shoes following reports from a previous investigation to maintain shoe integrity during testing. Two walking sessions on separate days were collected for 12 healthy participants, with an average total of 22 gait cycles per day.

Results

ICCs ranged from 0.020 to 0.964 for between‐day reliability, and within‐session ICC values ranged from 0.268 to 0.985. Between‐day ICC values of the relative measures (excursion and range of motion (ROM)) were higher than the absolute angle measures (angle at foot strike and peak angle). Largest differences were measured in the transverse plane, and the smallest differences in the sagittal plane. Bland‐Altman plots revealed best agreement in the frontal and sagittal planes. SEM values ranged from 0.04 to 3.5 for the between‐day reliability.

Conclusions

Between‐day reliability and within‐session variability were comparable to previous studies for adults walking barefoot and shod. This research demonstrates that the OFM can produce reliable data when applied to the assessment of a shod foot.
Modified bolster dressing with continuous suction improves skin graft survival for an oral cavity wound
Authors: Lee Eunkyu , Park Song I , Kim Donghyeok , Jin Hokyung , Jeong Han-Sin
Published: November 2018

Background

Skin engraftment of intraoral defects is known to be inconsistent due to mobility of the oral structure, uneven wounds, and accumulation of saliva under the skin graft. To improve the success rate of oral skin graft, we proposed a novel and simple dressing technique for intraoral skin graft to control saliva accumulation, in comparison with the conventional bolster dressing.

Methods

We retrospectively reviewed 31 patients reconstructed with skin graft in their intraoral defect. The patients were divided into two groups; conventional bolster group ( n = 21) and modified bolster group ( n = 10). In the modified bolster group, a polyvinyl alcohol sponge was designed to fit the skin graft and a suction drain was inserted with tagging suture to apply continuous suction. We analyzed the success rate, the size of the skin grafts and clinical variables of each method.

Results

The overall success rate of oral skin graft was not different between the two groups (90.0 and 90.5%). However, partial necrosis in the engrafted skin was observed frequently in the control group (57.1% versus 20.0%). The relative engrafted area was significantly higher in the modified bolster group (55.0 ± 11.6% versus 23.0 ± 18.7%, p = 0.015). The duration of bolster dressing and the time to start an oral diet were shorter in the modified bolster group.

Conclusions

Our modified method could be easily applied for removing saliva accumulation under a skin graft and for enhancing skin engraftment of an oral cavity wound.
The Pituitary Is a Candidate Organ That Modulates Circulating Klotho Levels
Authors: Sato Tetsuhiko , Komaba Hirotaka , Nagatani Tetsuya , Watanabe Tadashi , Kishida Yugo , Fukagawa Masafumi
Published: November 2018

Context

The antiaging protein Klotho is shed and released into the blood stream (soluble Klotho). Growth hormone (GH) is considered an active Klotho regulator, because growth retardation is described in Klotho-deficient mice. The origin of circulating Klotho is, however, not fully understood.

Objectives

Our objective was to analyze a possible role of the pituitary in regulating soluble Klotho in patients with pituitary adenomas.

Patients, Design, and Setting

We analyzed serum levels of soluble Klotho, GH, and insulin-like growth factor 1 (IGF-1) from 21 consecutive patients in our center with pituitary tumor, 7 with GH-producing adenomas (GHomas), and 14 with non–GH-producing pituitary adenomas (non-GHomas), before and after endoscopic transsphenoidal surgery (eTSS).

Main Outcome Measure

Soluble Klotho levels were determined by ELISA with antihuman Klotho antibodies.

Results

Baseline soluble Klotho levels in all patients, those with GHoma and those with non-GHoma, were 542 (median) (interquartile range: 403, 652), 1083 (425, 1213), and 525 (399, 590), respectively. A drastic reduction in Klotho levels was identified in those with GHoma, accompanied by decreases in GH and IGF-1 levels, after eTSS. Interestingly, patients with non-GHoma had significant declines in soluble Klotho without any significant changes in GH levels. Moreover, an oral glucose tolerance test revealed that soluble Klotho levels decreased, whereas a paradoxical GH peak was observed after glucose intake in a patient with GHoma.

Conclusions

Our data suggest that the pituitary may be a key organ that regulates circulating Klotho concentrations, implying that the pituitary possibly controls circulating Klotho through GH-dependent and/or GH-independent mechanisms.
Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression
Authors: Piipponen Minna , Heino Jyrki , Kähäri Veli-Matti , Nissinen Liisa
Published: November 2018

Long non-coding RNAs (lncRNAs) regulate various cellular processes, and they have emerged as potential biomarkers and therapeutic targets in cancer. We have previously characterized the oncogenic role of lncRNA PICSAR (p38 inhibited cutaneous squamous cell carcinoma associated lincRNA) in cutaneous squamous cell carcinoma (cSCC), the most common metastatic skin cancer. In this study, we show that knockdown of PICSAR in cSCC cells upregulates expression of α2, α5 and β1 integrins, resulting in increased cell adhesion and decreased cell migration on collagen I and fibronectin. In contrast, overexpression of PICSAR in cSCC cells downregulates expression of α2, α5 and β1 integrins on cell surface, resulting in decreased cell adhesion on collagen I and fibronectin and increased cell migration. These results demonstrate a novel mechanism for regulation of the expression of collagen and fibronectin binding integrins by lncRNA PICSAR, leading to altered adhesion and migration of cSCC cells.

This article has an associated First Person interview with the first author of the paper.
Development and characterization of a new cell line derived from European eel Anguilla anguilla kidney
Authors: Chen Bin , Zheng Zaiyu , Yang Jinxian , Chi Hongshu , Huang He , Gong Hui
Published: November 2018

A new cell line derived from the kidney of European eel, Anguilla anguilla, has been established and characterized. This cell line, designated as EK, has been maintained in Leibovitz's L-15 supplemented with 10% fetal bovine serum for over 24 months, and subcultured more than 60 times. This cell line consists predominantly of fibroblast-like cells, and could grow at 15-37°C under an optimum temperature of 26°C. The origin of this cell line was confirmed by polymerase chain reaction (PCR) amplification and 18s recombinant (r)RNA sequencing. The chromosome analysis of EK cells at passage 58 revealed an ananeuploid karyotype. The EK cells were successfully transfected with the Pegfp-N1 plasmid, suggesting its potential in the genetic studies. The susceptibility test showed a significant cytopathic effect (CPE) in EK cells for Rana grylio virus, and the viral replication was evidenced with quantitative real-time PCR (qRT-PCR) assay. After poly(I:C) stimulation, the expression of the immune-related molecules including interferon regulatory factor-3 (irf3), interferon regulatory factor-7 (irf7) and cytochrome P450 (CYP450) were significantly up-regulated in EK cells, while the expression of transforming growth factor (TGF-β) was down-regulated. These results suggested the potential of EK cell line as a model in gene engineering, virus identification and environmental toxicology.
Gene2vec: gene subsequence embedding for prediction of mammalian N6-methyladenosine sites from mRNA
Authors: Zou Quan , Xing Pengwei , Wei Leyi , Liu Bin
Published: November 2018

N6-Methyladenosine (m6A) refers to methylation modification of the adenosine nucleotide acid at the nitrogen-6 position. Many conventional computational methods for identifying N6-methyladenosine sites are limited by the small amount of data available. Taking advantage of the thousands of m6A sites detected by high-throughput sequencing, it is now possible to discover the characteristics of m6A sequences using deep learning techniques. To the best of our knowledge, our work is the first attempt to use word embedding and deep neural networks for m6A prediction from mRNA sequences. Using four deep neural networks, we developed a model inferred from a larger sequence shifting window that can predict m6A accurately and robustly. Four prediction schemes were built with various RNA sequence representations and optimized convolutional neural networks. The soft voting results from the four deep networks were shown to outperform all of the state-of-the-art methods. We evaluated these predictors mentioned above on a rigorous independent test data set and proved that our proposed method outperforms the state-of-the-art predictors. The training, independent, and cross-species testing data sets are much larger than in previous studies, which could help to avoid the problem of overfitting. Furthermore, an online prediction web server implementing the four proposed predictors has been built and is available at http://server.malab.cn/Gene2vec/.
Το αρχείο του Χαράλαμπου Μπούρα στο Μουσείο Μπενάκη: Η γνωστή και άγνωστη πλευρά του αρχιτέκτονα και η φωτογραφική ματιά ενός βυζαντινολόγου
Authors: ΜΠΟΥΡΑ (Natalia BOURA) Ναταλία , ΤΣΙΡΓΙΑΛΟΥ (Aliki TSIRGIALOU) Αλίκη
Published: November 2018

Αφορμή για την εισήγηση αυτή στάθηκε η απόφαση της οικογένειας του καθηγητή Χαράλαμπου Μπούρα να δωρίσει το πολύτιμο αρχείο του στο Μουσείο Μπενάκη. Πρόκειται για μια πρώτη παρουσίαση των θεματικών ενοτήτων τού παραδειγματικά ταξινομημένου υλικού που συγκέντρωσε από τα φοιτητικά του χρόνια, έως τις πιο πρόσφατες μελέτες του, με σκοπό τη γνωριμία με τον ταλαντούχο αρχιτέκτονα και δεινό φωτογράφο πίσω από τον γνωστό σε όλους καθηγητή – ιστορικό της Αρχιτεκτονικής και βυζαντινολόγο.
Once more on the Blachernae tradition in Old Russia
Authors: ETINHOF Olga
Published: November 2018

The idea of the protection by the Virgin and her Robe was very important in Old Russia. According to the Paterikon of the Monastery of the Caves, the Virgin sent architects to Kiev to construct the monastery’s church. Under Andrew Bogoliubsky the veneration of the Intercession of the Virgin began to spread. The layout of the building complexes in Vladimir and in the Moscow Kremlin, both of which comprised a Dormition Cathedral and a church of the Deposition of the Robe, reflected the sacred topography in Blachernae.
Ο ναός της Μεταμορφώσεως του Σωτήρος (Σώτειρα του Κοττάκη) στην Αθήνα. Νεότερα στοιχεία και παρατηρήσεις.
Authors: ΒΟΛΤΥΡΑΚΗ (Eleftheria VOLTYRAKI) Ελευθερία
Published: November 2018

Ο ναός της Μεταμορφώσεως του Σωτήρος (Σώτειρα του Κοττάκη) ανάγεται στους μεσοβυζαντινούς χρόνους και ακολουθεί τον αρχιτεκτονικό τύπο του απλού τετρακιόνιου με επιμηκυσμένο ιερό ή του σύνθετου σταυροειδούς εγγεγραμμένου με συνεπτυγμένο ιερό. Κατά τη διάρκεια του 19ου και του 20ού αιώνα δέχθηκε πολλές επεμβάσεις και επεκτάσεις που αλλοίωσαν την αρχική μορφή του. Κατά τη διάρκεια πρόσφατων εργασιών κατέστη εφικτή η παρατήρηση δομικών λεπτομερειών του, ενώ αποκαλύφθηκαν και νέα στοιχεία, όπως η εσωτερική όψη της τοιχοποιίας του και τμήματα των αρχικών ξύλινων ελκυστήρων.
Regarding the dating of the church of the Panagia Gorgoepekoos in Athens
Authors: STOUFI-POULIMENOU Ioanna
Published: November 2018

The church of the Panagia Gorgoepekoos in Athens is an unicum in Byzantine architecture and has been linked to a Byzantine “classicism”. Its dating has been a point of argument, as it has been dated from the ninth to the fifteenth century, but the end of the twelfth century has been proposed as the most probable period of its construction. It will be shown that there is evidence for dating the monument in the thirteenth century, during the period of Frankish rule.
Ο Πύργος στο Πιτυός της Χίου
Authors: ΜΙΣΑΗΛΙΔΟΥ (Anna MISSAILIDIS) Άννα
Published: November 2018

Στη βορειοανατολική Χίο βρίσκεται ο πύργος του Πιτυούς, με σημαντική στρατηγική σημαντική στρατηγική θέση στο οχυρωματικό δίκτυο της γενουατοκρατίας, διότι επόπτευε τόσο αγροτικές όσο και στρατιωτικές θέσεις. Το Πιτυός ήταν έδρα castellanus και είχε το μονοπώλιο παραγωγής πίσσας από τερεβινθίνη, που χρησιμοποιούνταν ως υγρομονωτικό υλικό για πλοία και στέγες. Στον πύργο εντοπίζονται τρεις κατασκευαστικές φάσεις, που ανάγονται από τα ύστερα βυζαντινά χρόνια έως και τον πρώιμο 16ο αιώνα.
Αχειροποίητος Θεσσαλονίκης: Μια επανεξέταση των αφιερωματικών επιγραφών στα ψηφιδωτάτου τριβήλου
Authors: ΡΑΠΤΗΣ (Κonstantinos Th. RAPTIS) Κωνσταντίνος Θ.
Published: November 2018

Υπό το πρίσμα της πρόσφατης αναθεώρησης της αρχιτεκτονικής της Αχειροποιήτου στη Θεσσαλονίκη καιτην αναχρονολόγηση της ίδρυσής της περί το έτος 500, την περίοδο βασιλείας του Αναστασίου Α΄ (491-518), επανεξετάζονται οι αφιερωματικές επιγραφές των ψηφιδωτών που κοσμούν τα εσωράχια των τόξων του τριβήλου, και επιχειρείται η ταυτίση τόσο των ονομαζόμενων όσο και των αποσιωπημένων δωρητών, εντάσσοντας την χορηγία για την κατασκευή τους στο κοινωνικοπολιτικό, κοσμικό και εκκλησιαστικό πλαίσιο της περιόδου.
Παναγία Οδηγήτρια και τρεις Ιεράρχες. Αμφιπρόσωπη εικόνα του Βυζαντινού Μουσείου Αθηνών
Authors: ΑΧΕΙΜΑΣΤΟΥ-ΠΟΤΑΜΙΑΝΟΥ (Myrtali ACHEIMASTOU-POTAMIANOU) Μυρτάλη
Published: November 2018

Η μεγάλη αμφιπρόσωπη, λιτανευτική εικόνα του Βυζαντινού Μουσείου, εξαίρετο έργο του πρώιμου 14ου αιώνα, είναι η πρώτη γνωστή με παράσταση των Τριών Ιεραρχών. Ανιχνεύονται τα συναφή και παράλληλα της σπάνιας εικονολογικής σύνθεσης της Παναγίας Οδηγήτριας με τους Τρεις Ιεράρχες και ερευνώνται τα χαρακτηριστικά εικονογραφίας και ύφους της εικόνας. Η συγγένειά της ιδίως με τις διακοσμήσεις των Αγίων Αποστόλων της Θεσσαλονίκης και της μονής της Χώρας οδηγούν στην άποψη ότι πρόκειται για σύγχρονο έργο Κωνσταντινουπολίτη μαΐστορα, που ζωγραφήθηκε ίσως για ανώτερο εκκλησιαστικό αξιωματούχο, στην Κωνσταντινούπολη ή τη Θεσσαλονίκη.
Παρατηρήσεις σε παναγιάρια της μονής Βατοπεδίου (14ος-16ος αιώνες)
Authors: ΛΙΑΚΟΣ Δημήτρης
Published: November 2018

Στη μονή Βατοπεδίου φυλάσσονται είκοσι δύο παναγιάρια που χρονολογούνται από τον 14ο έως τον 19ο αιώνα. Η παρούσα μελέτη αφορά σε πέντε μόνο έργα του 14ου-16ου αιώνα· συγκεκριμένα, επανεξετάζονται τέσσερα δημοσιευμένα και παρουσιάζεται ένα αδημοσίευτο αντικείμενο. Από την πραγμάτευσή τους προκύπτουν νέα στοιχεία που αφορούν στο καλλιτεχνικό τους ιδίωμα, τη χρονολόγηση και την προέλευσή τους. Παράλληλα, διατυπώνονται σκέψεις γύρω από τους παραγγελιοδότες τους αλλά και τον τρόπο κτήσης τους από τη μονή.
Optimization of extraction of genomic DNA from archived dried blood spot (DBS): potential application in epidemiological research & bio banking
Authors: Kumar Abhinendra , Mhatre Sharayu , Godbole Sheela , Jha Prabhat , Dikshit Rajesh
Published: November 2018

Background:Limited infrastructure is available to collect, store and transport venous blood in field epidemiological studies. Dried blood spot (DBS) is a robust potential alternative sample source for epidemiological studies & bio banking. A stable source of genomic DNA (gDNA) is required for long term storage in bio bank for its downstream applications. Our objective is to optimize the methods of gDNA extraction from stored DBS and with the aim of revealing its utility in large scale epidemiological studies. 

Methods:The purpose of this study was to extract the maximum amount of gDNA from DBS on Whatman 903 protein saver card. gDNA was extracted through column  (Qiagen) & magnetic bead based (Invitrogen) methods. Quantification of extracted gDNA was performed with a spectrophotometer, fluorometer, and integrity analyzed by agarose gel electrophoresis. 

Result:Large variation was observed in quantity & purity (260/280 ratio, 1.8-2.9) of the extracted gDNA. The intact gDNA bands on the electrophoresis gel reflect the robustness of DBS for gDNA even after prolonged storage time. The extracted gDNA amount 2.16 – 24 ng/µl is sufficient for its PCR based downstream application, but unfortunately it can’t be used for whole genome sequencing or genotyping from extracted gDNA. Sequencing or genotyping can be achieved by after increasing template copy number through whole genome amplification of extracted gDNA. The obtained results create a base for future research to develop high-throughput research and extraction methods from blood samples.

Conclusion:The above results reveal, DBS can be utilized as a potential and robust sample source for bio banking in field epidemiological studies.
ANIMA: Association network integration for multiscale analysis
Authors: Deffur Armin , Wilkinson Robert J. , Mayosi Bongani M. , Mulder Nicola M.
Published: November 2018

Contextual functional interpretation of -omics data derived from clinical samples is a classical and difficult problem in computational systems biology. The measurement of thousands of data points on single samples has become routine but relating ‘big data’ datasets to the complexities of human pathobiology is an area of ongoing research. Complicating this is the fact that many publicly available datasets use bulk transcriptomics data from complex tissues like blood. The most prevalent analytic approaches derive molecular ‘signatures’ of disease states or apply modular analysis frameworks to the data. Here we describe ANIMA (association network integration for multiscale analysis), a network-based data integration method using clinical phenotype and microarray data as inputs. ANIMA is implemented in R and Neo4j and runs in Docker containers. In short, the build algorithm iterates over one or more transcriptomics datasets to generate a large, multipartite association network by executing multiple independent analytic steps (differential expression, deconvolution, modular analysis based on co-expression, pathway analysis) and integrating the results. Once the network is built, it can be queried directly using Cypher (a graph query language), or by custom functions that communicate with the graph database via language-specific APIs. We developed a web application using Shiny, which provides fully interactive, multiscale views of the data. Using our approach, we show that we can reconstruct multiple features of disease states at various scales of organization, from transcript abundance patterns of individual genes through co-expression patterns of groups of genes to patterns of cellular behaviour in whole blood samples, both in single experiments as well in meta-analyses of multiple datasets.
Active Acquisition for multimodal neuroimaging
Authors: Cole James H. , Lorenz Romy , Geranmayeh Fatemeh , Wood Tobias , Hellyer Peter , Williams Steven , Turkheimer Federico , Leech Robert
Published: November 2018

In many clinical and scientific situations the optimal neuroimaging sequence may not be known prior to scanning and may differ for each individual being scanned, depending on the exact nature and location of abnormalities. Despite this, the standard approach to data acquisition, in such situations, is to specify the sequence of neuroimaging scans prior to data acquisition and to apply the same scans to all individuals. In this paper, we propose and illustrate an alternative approach, in which data would be analysed as it is acquired and used to choose the future scanning sequence: Active Acquisition. We propose three Active Acquisition scenarios based around multiple MRI modalities. In Scenario 1, we propose a simple use of near-real time analysis to decide whether to acquire more or higher resolution data, or acquire data with a different field-of-view. In Scenario 2, we simulate how multimodal MR data could be actively acquired and combined with a decision tree to classify a known outcome variable (in the simple example here, age). In Scenario 3, we simulate using Bayesian optimisation to actively search across multiple MRI modalities to find those which are most abnormal. These simulations suggest that by actively acquiring data, the scanning sequence can be adapted to each individual. We also consider the many outstanding practical and technical challenges involving normative data acquisition, MR physics, statistical modelling and clinical relevance. Despite these, we argue that  Active Acquisition allows for potentially far more powerful, sensitive or rapid data acquisition, and may open up different perspectives on individual differences, clinical conditions, and biomarker discovery.
Front Matter: Volume 6 (Proceedings of CBU)
Authors: Hájek Petr , Vít Ondřej
Published: November 2018

This PDF file contains the front matter associated with CBU Proceedings Volume 6 including the Title Page, Copyright information, Table of Contents, Introduction, and Conference Committee listing.
PRÁTICAS PEDAGÓGICAS INTERDISCIPLINARES COM O USO DE TEXTOS MULTIMODAIS
Authors: Amorim Evandro Dias , Lira Mirtes Ribeiro de
Published: November 2018

Resumo: A implementação de práticas pedagógicas interdisciplinares demanda a adoção de ações docentes inovadoras, capazes de promover a reorganização e ressignificação do conhecimento, como forma de adequar o ensino às reais necessidades da sociedade hodierna, e a multimodalidade por ser um fenômeno dinâmico, que congrega múltiplas linguagens e representações, torna-se um dos suportes imprescindíveis para a concretização destas ações. Este artigo apresenta um estudo sobre a produção científica nos mestrados profissionais em educação acerca de práticas pedagógicas interdisciplinares pautadas na utilização de textos multimodais. A pesquisa foi realizada no Banco de Dissertações dos Mestrados Profissionais em Educação em funcionamento no país e estendeu-se também aos seguintes periódicos: Revista Brasileira de Educação/ANPED, Educação e Pesquisa/USP e Educação e Realidade/UFRGS. O estudo foi direcionado às produções desenvolvidas entre os anos de 2012 e 2016. Os resultados obtidos na pesquisa demostram que os estudos referentes às práticas pedagógicas interdisciplinares e à utilização de recursos linguísticos multimodais na prática docente são ainda muito incipientes, tanto nos mestrados profissionais em educação, quanto nos periódicos acima referenciados. Abstract: The implementation of interdisciplinary pedagogical practices demands the adoption of innovative teaching actions, capable of promoting the reorganization and re-signification of knowledge, as a way of adapting teaching to the real needs of today's society, and multimodality as a dynamic phenomenon, that assembles multiple languages and representations, it becomes one of the indispensable supports for the accomplishment of these actions.. This article presents a study about the scientific production in the education professional master about interdisciplinary pedagogical practices based on the use of multimodal texts. The research was carried out in the Bank of Dissertations of Education Professional Master in operation in the country and also extended to the following periodicals: Brazilian Journal of Education / ANPED, Education and Research / USP and Education and Reality / UFRGS. The study was directed to the productions developed between the years 2012 and 2016. The results obtained in the research show that the studies referring to interdisciplinary pedagogical practices and the use of multimodal linguistic resources in teaching practice are still very incipient, both in professional masters in education and in the periodicals mentioned above.
OBSERVANDO OS MOVIMENTOS RETÓRICOS NO ARTIGO ACADÊMICO NA ÁREA DA MULTIMODALIDADE
Authors: Lendl Aluizio
Published: November 2018

O presente estudo tem como objetivo descrever e interpretar as unidades retóricas que compõem a área disciplinar da Multimodalidade. Trata-se de uma pesquisa cuja natureza é exploratório-descritiva. O corpus foi composto por quatro artigos da área de Multimodalidade, publicados em língua portuguesa em periódicos brasileiros indexados no banco de dados WebQualis da CAPES. Fundamentamo-nos nas perspectivas teórico-metodológicas de Swales (1990) e Motta-Roth; Hendges (2010) no que diz respeito ao estudo das unidades retóricas. O conceito de cultura disciplinar está filiado a Hyland (2000). O que concerne às unidades retóricas dos artigos, na seção de introdução, não encontramos indícios de revisão da literatura, embora sejam apresentadas referências das principais obras. Na seção de metodologia, as informações são construídas de forma incompleta. Na unidade dos resultados, são apresentados os principais achados do estudo. Por fim, evidenciamos que os artigos acadêmicos da cultura disciplinar delimitada são construídos de forma diversas, sem obedecer normas ou práticas investigativas disciplinares. Esperamos que nosso estudo possa contribuir com os estudos retóricos em artigos acadêmicos da área da Multimodalidade e ressaltamos a necessidade de estudos que tomem essas unidades retóricas como foco.
REFLEXÕES DIDÁTICO-PEDAGÓGICAS SOBRE A “ARTE DE MANDAR” NO ENSINO DE LÍNGUA PORTUGUESA
Authors: Felipe Márcia Da Gama Silva
Published: November 2018

É incontestável a necessidade do ensino das regras gramaticais e da estrutura da Língua Portuguesa. No entanto, não menos necessário é o seu intercâmbio com aspectos culturais que influenciam na prática do falante, principalmente no âmbito do ensino do português como língua estrangeira. O estudo do Modo Imperativo é um exemplo de que essa intercessão se faz necessária, dado que seu aspecto semântico vai muito além das definições normalmente apresentadas em gramáticas tradicionais. A noção de ordem associada a esse modo verbal pode também ser demonstrada em outras construções, raramente contempladas com esse enfoque no ensino hodierno. Isso posto, o desenvolvimento deste artigo terá os seguintes objetivos: analisar a realidade do ensino do Modo Imperativo; refletir acerca de atividades linguísticas, cuja noção de ordem lhes seja subjacente e propor um tratamento semântico/semiótico para o ensino da noção de ordem e o necessário entrelaçamento Língua & cultura, cuja negligência coloca em risco todo o esforço em prol do uso proficiente da Língua Portuguesa.
LÍNGUA PORTUGUESA COMO SEGUNDA LÍNGUA PARA SURDOS: PROCEDIMENTOS DA COERÊNCIA NA REESCRITA DO TEXTO
Authors: Correia Claudio Manoel Carvalho
Published: November 2018

A sociedade se defronta continuamente com inúmeras situações nas quais a escrita da língua está presente e tem relevância. Para o sujeito surdo, o texto escrito constitui uma ferramenta de comunicação entre ele e os ouvintes. Na busca de alternativas para o ensino da Língua Portuguesa para surdos, muitas questões têm exigido atenção de pesquisadores e algumas interferências podem ser evitadas se trabalhadas preventivamente. Pensando nisso, professores da Universidade Federal de Sergipe - UFS desenvolveram o curso de extensão: Ensino de Língua Portuguesa para surdos. Esse curso foi uma proposta efetiva de ensino do português como segunda língua para surdos, considerando a LIBRAS como primeira língua dessa comunidade. Com base nisso e tomando como objeto de estudo a escrita da Língua Portuguesa, analisa-se, neste artigo, seis textos produzidos por três alunos surdos com nível médio concluído.  Foi avaliado se a intervenção pedagógica possibilitou, na reescrita dos textos, um melhor desenvolvimento dos procedimentos de coerência de acordo com Costa Val (2006). Para sua fundamentação, o presente estudo apoia-se nos pressupostos teóricos da Linguística a partir das abordagens de Antunes (2005); Brochado (2003); Costa Val (2006); Faria (2001); Fávero e Koch (2008); Koch (2009); Marcuschi (2008) e Salles (2004). De maneira geral, verificou-se que após o curso de extensão, a reescrita das produções conseguiu contemplar com mais propriedade os critérios de coerência elencados por Costa Val (2006) e permitiu aos textos uma melhor compreensão de sentido.
O TEXTO E O ENSINO DA LÍNGUA
Authors: Martins Aira Suzana Ribeiro
Published: November 2018

Muito se discute sobre a dificuldade dos estudantes em interpretar satisfatoriamente e redigir um texto de forma coerente e coesa. Alguns acreditam que essas competências podem ser adquiridas com o hábito de leitura. Sem dúvida, a prática de leitura é essencial para o desenvolvimento da compreensão leitora e da escrita, porém essa atividade não é suficiente para que o indivíduo seja capaz de perceber o funcionamento da língua e refletir sobre ela. Com o conhecimento da Gramática, o indivíduo será capaz de reconhecer as características dos vários usos a que a língua se propõe e ter a habilidade de empregar o registro adequado às necessidades comunicativas. Nesse sentido, nosso trabalho pretende refletir sobre a necessidade do ensino da Gramática para que o aluno adquira condições de, futuramente, buscar informação, de forma autônoma, em diferentes fontes. Para que esse objetivo seja alcançado, é necessário que a reflexão sobre os usos da língua seja constante, tendo o texto como base. Desse modo, propomos, neste texto, uma atividade de leitura associada ao estudo dos elementos linguísticos. Tencionamos, com tal prática, que o aluno perceba a função da língua na construção do texto e faça uma reflexão sobre seus usos. Acreditamos, ainda, que atividades como essa contribuam para o respeito às variedades linguísticas e a compreensão da necessidade de adequação do registro às diferentes situações por parte do aluno.
Household factors associated with use of postnatal care services
Authors: Mukonka Priscar Sakala , Mukwato Patricia Katowa , Kwaleyela Concepta Namukolo , Mweemba Oliver , Maimbolwa Margaret
Published: November 2018

Background:

The postpartum period is one of the most vulnerable and critical periods for both the mother and the newborn. Inadequate care during this period may result in death or disability as well as missed opportunities to promote health behaviours.

Aims:

To determine the household factors that are associated with use of postnatal care services by mothers.

Methods:

An electronic search was conducted, including databases such as PubMed, Hinari, Google Scholar, Cochrane library, Science Direct and BioMed Central, using the following search terms: postpartum care, postnatal care, household behaviours, challenges, barriers, use and postpartum women.

Findings:

All the reviewed articles revealed that postpartum care services were not fully used by postpartum women and household factors played a big role. Background characteristics of women such as age, marital status, parity, level of education and religion were also found to influence uptake.

Conclusions:

Household factors, such as accessibility; awareness and knowledge; socioeconomic status and financial difficulties; women's empowerment; traditional beliefs and cultural practices and background characteristics have been found to play a significant role in the use of postnatal services by postpartum mothers
A review of thermoduric bacteria: significance, sources and management part 2
Authors: Henderson Andrew
Published: November 2018

Thermodurics are ‘heat resistant’ bacteria capable of surviving pasteurisation and have the potential to cause quality and shelf life issues in dairy products. They are ubiquitous in the environment and can be present in a wide range of sources. Managing thermoduric levels in milk can be challenging, though focus on hygiene of the herd and milking equipment should achieve effective control.
CattleReview
Authors: Barrett David C
Published: November 2018

Introduction:

As we approach World Antibiotic Awareness Week, this edition of Cattle Review considers recent publications regarding antimicrobial resistance (AMR) and antimicrobial use (AMU). Both are areas of ever-increasing research focus as the need to change prescribing practices on-farm intensifies further.
Achieving effective vaccination to optimise pig herd health
Authors: Gale Christina , Pattison Emma
Published: November 2018

Vaccination is becoming increasingly important, particularly with the current pressures on the pig industry to reduce the use of antimicrobials. A number of factors contribute to a successful and effective vaccination session, not only for pig health but also for worker welfare. The timing of vaccination is crucial in ensuring the stimulation of an effective immune response to prevent disease outbreaks. Pig handling and duration of the session can also have an impact on the quality of vaccination. Data collected from vaccination sessions provides traceability and can be utilised when considering lung health and revising vaccination protocols on farms.
Practical diagnostic approach to the coughing horse
Authors: Pirie R Scott
Published: November 2018

Coughing is a common presenting sign in equine clinical practice, which results from chemical and/or mechanical stimulation of cough receptors located within the conducting airways. The presence of a cough is therefore diagnostically beneficial as it confirms either primary or secondary involvement of the airways. Despite its value in anatomically localising the disease process per se, the number of respiratory diseases and disorders that may present with a cough are numerous; hence, further diagnostic investigation is generally required before a definitive diagnosis can be reached. Furthermore, the absence of a cough does not rule out involvement of the airways; in such cases, reliance is based on other less specific localising clinical signs. This review will cover the basic mechanisms that underpin coughing; summarise the diseases and disorders that may present with a cough; and provide an overview of appropriate diagnostic approaches that may be adopted in the investigation of the coughing horse.