bluuebunny/crossref_metadata_2025 huggingface dataset:
IDENTIFIKASI BANGUNAN PUSAKA DI WONOSOBO
Authors: Kurniawan Wahyu , Muafani Muafani
Published: December 2018

Keunikan kota-kota kecil tradisional di negara timur terletak pada kesinambungan dan keterkaitan antar budaya, iklim dan seni-kriya, apabila hal ini sebagai kecenderungan perkembangan kota yang intuitif tetapi juga rasional mampu dibina terus, tidak akan pernah muncul kerisauan akan krisis identitas. Seorang arsitek mempunyai tanggung jawab yang besar untuk bertukar, menyumbangkan karya yang suatu saat nanti dinilai layak dilestarikan. Sebagai negara yang memiliki sejarah yang panjang, dengan tradisi yang kuat dan beragam serta pengalaman dijajah negara lain, tak pelak kita memiliki warisan arsitektur tradisional dan peninggalan kolonial yang sangat kaya, tersebar di berbagai pelosok kota. Hal inilah yang dapat kita jumpai di Kabupaten Wonosobo yang tercatat sebagai kota kedua setelah Yogyakarta yang menyatakan bergabung dengan Republik ini, sehingga akan menjadi lebih menarik lagi untuk dijadikan sebagai bahan kajian Penelitian Studi Literatur yang memadukan data lapangan dengan data pustaka dan dilengkapi dengan wawancara para pelaku sejarah untuk memperoleh hasil yang maksimal. Penelitian ini bertujuan untuk mengidentifikasi objek penelitian. Data yang ada dalam penelitian ini diperoleh dengan menggunakan metode observasi untuk mengidentifikasi objek penelitian sebagai data utama dalam penelitian dan dilengkapi dengan kajian data pustaka yang terkait dengan bangunan cagar budaya yang ada di Kota Wonosobo.
PROFIL TINGKAT KESEGARAN JASMANI PESERTA DIDIK KELAS X PAKET KEAHLIAN OTOMATISASI DAN TATA KELOLA PERKANTORAN (OTP) SEMESTER 1 TAHUN PELAJARAN 2017/2018
Authors: Setiyono Wahyudi
Published: December 2018

Tujuan penelitian ini adalah untuk mengetahui bagaimana profil tingkat kese-garan jasmani peserta didik kelas X paket keahlian Otomatisasi Dan Tata Kelola Perkantoran pada semester 1 tahun pelajaran 2017/2018. Metode penelitian yang digunakan adalah kualitatif dengan menggunakan Tes Kesegaran Jasmani Indonesia (TKJI). Populasinya adalah peserta didik kelas X paket keahlian Otomatisasi Dan Tata Kelola Perkantoran pada semester 1 tahun pelajaran 2017/2018. Teknik sampling yang digunakan adalah total sampling dengan jumlah 96 peserta didik. Teknik analisis datanya menggunakan teknik deskriptif persentase. Berdasarkan hasil penelitian terhadap 96 peserta didik yang melakukan tes TKJI ada 16 (17%) peserta didik masuk dalam kategori kurang sekali, 35 (36%) peserta didik masuk kategori kurang, 40 (42%) masuk kategori sedang, 5 (5%) peserta didik masuk kategori baik, dan tidak ada peserta didik masuk kategori baik sekali. Dengan demikian dapat disimpulkan bahwa tingkat kebugaran peserta didik kelas X paket keahlian Otomatisasi Dan Tata Kelola Perkantoran pada semester 1 tahun pelajaran 2017/2018 sebagian besar termasuk dalam kategori kurang dan sedang. Berdasarkan simpulan hasil penelitian di atas, maka disarankan kepada guru pendidkan jasmani olaharga dan kesehatan SMK Negeri 1 Wonosobo dapat melakukan proses pembelajaran yang dapat memacu kesegaran jasmani dengan tetap memperhatikan kondisi peserta didik dan metode pendekatan pembelajaran yang tepat serta memperhatikan factor keamanan sehingga peserta didik pada akhirnya dapat mencapai tingkat kesegaran jasmani yang lebih baik.
POLA ALIRAN FLUIDA PADA DELIQUIDISER
Authors: Indrawati Ragil T
Published: December 2018

ujuan penelitian ini untuk mengetahui fenomena pola aliran fluida yang terjadi pada deliquidiser serta properties yang ada pada daerah inlet, drain, oil outlet dan gas outlet. Penelitian dilakukan menggunakan pendekatan simulasi pemodelan matematis Computational Fluid Dynamic (CFD) menggunakan software Ansys. Dalam penelitian ini diasumsikan bahwa model akan disimulasikan skala 1:1 pada 2 phase fluida yaitu fase gas dan liquid dengan 2 jenis fluida (gas dan liquid). Simulasi akan mengacu pada kondisi steady state dan tidak ada solid content. Asumsi inlet fluid pada kondisi 5% turbulence, komposisi gas dan fraksi volume gas & liquid ialah konstan. Drag coefficient yang diguankan ialah 0.44 dengan working pressure 207 psi.Hasil penelitian menunjukkan bahwa bahwa persebaran fraksi gas dari bagian inlet tersebar secara merata pada semua bagian. Akan tetapi, setelah weirplate, ketika melewati nozzle dan menuju outlet gas, gas cenderung bergerak ke atas. Sedangkan, fraksi liquid mengalir dibagian bawah tengah ke bawah setelah fraksi gas. Gas dan liquid velocity streamline menunjukkan pola pergerakan dari inlet kemudian menumbuk weirplate, melewati nozzle dan keluar melalui outlet gas. Optimasi pada sistem telah dilakukan dan hasil yang diperoleh menunjukkan nilai fraksi gas dan fraksi liquid sebesar 0.74 dan 0.17 dalam aliran yang keluar dari bagian outlet. Sedangkan, untuk mass flow pada outlet gas sebesar 8.8 kg/s dan mass flow pada drain sebesar 0.05 kg/s.
Antidepressant, neuropharmacological activity and mode of action of theaflavin-3-gallate in in vitro and in vivo models of depression
Authors: Wang Ying , Chen Jing , Wang Jing , Guo Xin , Wang Ning , Yuan Jie
Published: December 2018

Herein the antidepressant-like effect of theaflavin-3-gallate, a plant polyphenolic compound in 1-methyl-4-phenyl pyridinium-induced neuronal injury in N2a cells used as an in vitro model of depression as well as in vivo. The results from MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) and lactic dehydrogenase assay revealed that theaflavin-3-gallate exerted a neuroprotective effect in N2a cells. Treatments with mixtures of 1-methyl-4-phenyl pyridinium (20 µM) and four concentration levels of theaflavin-3-gallate increased cell viability from 23.3 to 79.6% while lactic dehydrogenase leakage value decreased from 63.2 to 23.4 U/L. Fura-2-acetoxymethyl ester assay for Ca2+ concentration measurement revealed that different doses of theaflavin-3-gallate or fluoxetine (20 µM) reduced the intracellular Ca2+ overloading in N2a cells induced by 1-methyl-4-phenyl pyridinium. Inverted phase microscopy showed that theaflavin-3-gallate induced neurite outgrowth in 1-methyl-4-phenyl pyridinium-induced neurotoxicity in N2a cells. Theaflavin-3-gallate could significantly reduce the immobility time of mice in both forced swimming test and tail suspension test.Video Clip of Methodology:MTT Assay: 3 min 38 sec   Full Screen   Alternate
Secondary Thymoma among Adult Treated For Acute Lymphoblastic Lymphoma/Leukemia: Report of a Case and Review of the Literature
Authors: Bendari Mounia , Bencharef Hanaa , Khoubila Nisrine , Cherkaoui Siham , Lamchahab Mouna , Madani Abdellah , Rachid Mohamed , Qachouh Meryem , Oukache Bouchra , Quessar Asmaa
Published: December 2018

BACKGROUND: Concomitant thymoma and T- lymphoblastic/leukaemia lymphoma is possible. Secondary thymoma after treatment for T-lymphoblastic/leukaemia lymphoma was also occasionally reported, although this is quite rare.
CASE REPORT: We report a case of 44-year-old women with secondary thymoma after chemotherapy treatment for T Acute Lymphoblastic leukaemia/lymphoma. Diagnosis of lymphoblastic/leukaemia lymphoma was made in 2015 by morphological and histological study. The patient underwent Moroccan protocol for acute lymphoblastic leukaemia (MARALL) from 2015 to 2017 and achieved complete remission. One year later, the patient developed an anterior mediastinal mass, relapse was suspected, but the surgical biopsy was performed and histological, the mass showed thymoma.
CONCLUSION: At the time of diagnosis of thymoma for a patient treated for T-lymphoblastic/leukaemia lymphoma it is necessary to eliminate a relapse because the distinction between thymoma and T-lymphoblastic/leukaemia lymphoma is sometimes difficult, and the association is possible.
Endovascular Treatment of Wide Neck Aneurysms
Authors: Lazareska Menka , Aliji Vjolca , Stojovska-Jovanovska Elizabeta , Businovska Jasna , Mircevski Vladimir , Kostov Milenko , Papazova Marija
Published: December 2018

BACKGROUND: An aneurysm is an abnormal focal dilatation of an artery. Most of the unruptured aneurysms are asymptomatic and discovered incidentally or some of them symptomatic with mass effect or nerve palsy, but rupture of aneurysm results in a potentially life-threatening subarachnoid haemorrhage. Aneurysms with wide necks are defined by neck diameters greater than 4 mm or dome-to-neck ratios less than 2 and are the most difficult to treat with the endovascular method.
AIM: This study aimed to analyse the endovascular treatment of intracranial aneurysms with a wide neck.
METHODS: The study population included 37 patients with 46 aneurysms referred to the University Clinic of Radiology in Skopje, the Republic of Macedonia for endovascular treatment during the period January 2013 to May 2018. This study included 24 females and 13 males, ranging in age from 25 to 74 years.
RESULTS: From total 46 treated aneurysms 13 were ruptured and 33 unruptured. Six patients were with multiple aneurysms. In these study complex aneurysms were treated with combined technique, 5 with balloon-assisted coiling, 25 with stent-assisted coiling, 6 stents, 2 with flow diverter assisted coiling, 6 FD and 2 with partial coil filling without assistance device.
CONCLUSION: Aneurysms with wide neck remain a challenge for endovascular treatment. But the development of new techniques and materials in the treatment of aneurysms makes endovascular treatment of intracranial aneurysms safe and feasible.
PsAID12 Provisionally Endorsed at OMERACT 2018 as Core Outcome Measure to Assess Psoriatic Arthritis-specific Health-related Quality of Life in Clinical Trials
Authors: Orbai Ana-Maria , Holland Richard , Leung Ying Ying , Tillett William , Goel Niti , Christensen Robin , McHugh Neil , Gossec Laure , de Wit Maarten , Højgaard Pil , Coates Laura C. , Mease Philip J. , Birt Julie , Fallon Lara , FitzGerald Oliver , Ogdie Alexis , Shea Beverly , Strand Vibeke , Duffin Kristina Callis , Tugwell Peter , Beaton Dorcas , Gladman Dafna D.
Published: December 2018

Objective.

The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) psoriatic arthritis (PsA) working group is developing a Core Outcome Measurement Set for PsA clinical trials [randomized controlled trials (RCT) and longitudinal observational studies (LOS)] using the OMERACT Filter 2.1 instrument selection algorithm. Our objective was to assess the Psoriatic Arthritis Impact of Disease questionnaire (PsAID12) for the measurement of the core domain PsA-specific health-related quality of life (HRQOL).

Methods.

PsAID12 measurement property evidence gathered in a systematic literature review, and additional analyses conducted in LOS, were used to inform a consensus process. Analyses that had not been published were independently reviewed by the OMERACT technical advisory group. Data and process were presented, discussed in breakout groups, and voted on at the OMERACT conference (Terrigal, Australia, May 2018).

Results.

PsAID12 fulfilled the green (good to go) OMERACT standards for domain match, feasibility, reliability, and construct/longitudinal construct validity. Discrimination and thresholds of meaning were amber (caution but good enough to go forward). The overall working group recommendation was amber/provisional endorsement of PsAID12 for measuring PsA-specific HRQOL in RCT and LOS. Of 96 participants who voted at the PsA OMERACT workshop, 87.5% (84) voted “yes” to endorse this recommendation; 14 of the 96 were patient research partners (PRP) and 93% of them (13) voted “yes”; 82 participants were not PRP and 87% of them (71) voted “yes.”

Conclusion.

At OMERACT 2018, PsAID12 was the first patient-reported outcome measure provisionally endorsed as a core outcome measure for disease-specific HRQOL in PsA clinical trials. PsAID12 discrimination and improvement thresholds will be studied in future RCT.
Lorsque le corps de l’enfant s’en mêle
Authors: Cametz Olivier
Published: December 2018

La relation transférentielle avec l’enfant vient souvent se situer aux confins de l’articulation entre corps et psyché. La proximité temporelle des éprouvés initiaux de l’enfant au sein de la relation primaire et la prépondérance de la place du corps dans la structuration psychique en cours, augmentent la probabilité de leur survenue dans le travail thérapeutique avec l’enfant via ses manifestations corporelles. L’auteur revient sur l’évolution d’une analyse d’enfant au cours de laquelle le transfert installé a occasionné une régression jusqu’à la dimension des carences somato-psychiques, bousculant le cadre thérapeutique tel qu’il est envisagé habituellement.
Aristophanes in the Apology of Socrates
Authors: Stone Sophia
Published: December 2018

Résumé Nous serions en présence de la réaction la plus déplacée qui soit à une timēsis dans l’art oratoire juridique de l’Attique si Socrate avait pour de bon déclaré à son procès qu’on devrait donner au Prytanée des banquets en son honneur pour tout le restant de sa vie. Si Socrate avait effectivement fait cette proposition à son procès, ce serait à la fois un acte politique et un acte d’impiété. Il défendrait sa piété en montrant son impiété. Si Socrate l’a bien dit à son procès, il a donc à coup sûr scellé son destin. Cela expliquerait pourquoi, avec une si petite marge de culpabilité (trente votes sur 501 auraient suffi à acquitter Socrate des charges qui pesaient contre lui), le vote le condamnant à mort a été beaucoup plus important. Si Socrate n’a rien dit de tel à son procès, pourquoi Platon lui fait-il donc dire ces mots ? Platon a-t-il voulu nous indiquer que le procès n’était pas en fait une question de piété et que, de même que la contre-pénalité, il ne doit pas être pris au sérieux ? Ou bien est-ce ce que Socrate aurait dû dire, étant donné qu’il allait mourir de toute façon ? Ou alors Platon voulait-il tendre un doigt accusateur vers Aristophane, explicitement au début et implicitement à la fin ? Dans le présent article, je soutiens que l’ antitimèma proposée par Socrate est un ajout littéraire de Platon emprunté à Aristophane. En désaccord avec Brickhouse et Smith – et bien avant eux John Burnet –, je m’appuie sur des arguments et des indices probants tirés de ressources interdisciplaires de la rhétorique judiciaire, de l’histoire de la Grèce antique ainsi que de son histoire politique et sa culture, et de la grammaire et de la philosophie grecques. En partant des récits que nous ont légués Platon et Xénophon, j’analyse ensuite la culture et le contexte du Prytanée. Sur la base de ces indices et du contexte, je propose des arguments contraires aux philosophes qui ont prétendu, à la suite de Burnet, que des repas gratuits au Prytanée étaient « une revendication socratique » pour démontrer, en définitive, que la revendication vient de Platon, par le biais d’Aristophane.
Adriano en Siria de Metastasio. Un emperador hispano en la escena española del siglo XVIII
Authors: Romero Recio Mirella
Published: December 2018

Résumé Hadrien en Syrie de l’Italien Metastasio est un livret qui a été adapté et mis en musique par de nombreux compositeurs. L’objectif de l’article proposé ici est d’étudier les traductions et les adaptations qui ont été réalisées en Espagne au cours du xviii e siècle pour tenter de mesurer le rôle qu’a eu l’empereur Hadrien comme modèle pour les gouvernants jusque dans l’identification aux vertus de celui-ci.
The prudence principle and Economia Aziendale : A contribution towards resolving the IASB’s vacillations
Authors: Alexander David , Fiondella Clelia , Maffei Marco
Published: December 2018

Cet article cherche à expliquer les raisons d’une double application de la prudence dans le management et dans la comptabilité à partir d’une histoire de ses significations dans l’ economia aziendale depuis le milieu du XIX e siècle. L’article montre que, dans le cadre théorique italien, le principe de prudence s’est développé de manière à proposer des critères permettant de répondre aux évolutions des besoins économiques des firmes dans un contexte de transformations, tout en répondant aux besoins des différentes parties prenantes. L’analyse suggère qu’une mise en avant de la prudence en comptabilité est une condition nécessaire mais pas suffisante pour parvenir à atteindre les objectifs d’un reporting financier global. Une attention particulière doit être portée à la double application de la prudence dans la comptabilité et dans le management pour s’assurer que l’activité est menée dans les intérêts de la firme et de l’ensemble de ses parties prenantes.
La prudence en bonne et due forme : supervision et régulation bancaires internationales à l’aube de l’ère globale
Authors: Drach Alexis
Published: December 2018

Cet article propose d’étudier une activité pour laquelle la prudence est une caractéristique essentielle : celle de superviseur bancaire. Il se focalise sur les années 1970 et 1980, durant lesquelles cette activité gagne en importance et s’internationalise, et sur le Comité de Bâle sur le Contrôle Bancaire, qui est son principal forum international de discussion. L’article montre trois évolutions majeures de la prudence bancaire durant la période considérée : le rôle accru qu’y jouent les autorités, son internationalisation, et sa marche vers une forme plus quantitative et plus focalisée sur le capital. À partir de l’exploitation de fonds d’archives encore largement inexplorés, il montre également l’imbrication de la prudence dans des enjeux politiques relatifs aux différences de conditions concurrentielles entre les banques des différents pays. Les formes de la prudence qui découlent de la supervision bancaire sont analysées conjointement à la manière dont ces formes voient le jour et au contexte de leur création. Ces formes sont analysées sous trois angles : celui de la profession de superviseur, celui des recommandations faites aux banques à travers les cas de la surveillance des risques de change et du risque pays, et celui de l’instauration d’un ratio de fonds propres commun à tous les pays. Premièrement, l’examen du développement quantitatif et qualitatif de la supervision bancaire montre que cette profession connaît une croissance et des changements importants à l’échelle nationale comme internationale, ce qui témoigne du rôle accru des autorités dans la prudence bancaire. Deuxièmement, les rapports du Comité de Bâle sur le risque de change et le risque pays témoignent de formes plus internationales de la prudence et de pratiques plus intrusives des superviseurs dans les affaires bancaires. Enfin, l’institutionnalisation de la prudence par la création d’une norme internationale de capitalisation bancaire s’apparente à la recherche toujours inachevée d’une formule de la prudence.
Le statut de l’intérimaire, une « innovation sociale » co-construite
Authors: Bourotte Nathalie , Eynaud-Chevalier Isabelle
Published: December 2018

De nouvelles formes d’emploi apparaissent depuis les années 2000, sous l’impulsion créative des technologies, qui poussent individus et entreprises à développer des façons inédites d’exercer une activité professionnelle. Ces modalités de mise au travail posent de nombreux défis, brouillent les repères et obligent à réinventer des équilibres justes entre autonomie et sécurité, entre efficacité économique et protection sociale, entre individualisation et maintien d’un cadre collectif. Dans ce contexte, il peut être utile de revisiter l’histoire de l’intérim en France, pour évaluer le caractère innovant de cette co-construction, tant sur le plan économique que juridique et social au sens large, et comprendre à quels besoins et défis elle a su répondre. L’exemple français est particulièrement riche d’enseignement car il est considéré comme le plus abouti, particulièrement en matière de construction du statut social de l’intérimaire.
La Business Track de l’ESCP Europe . Un cursus sur-mesure pour les étudiants « professionnels »
Authors: de Boysson Isabelle
Published: December 2018

Focus Lancé en septembre 2017, la Business Track est une nouvelle voie au sein du programme du master grande école (MIM) de ESCP Europe. Elle permet d’accompagner et soutenir ses étudiants dans leurs expériences et engagements professionnels. Il s’agit d’un dispositif optionnel proposé aux étudiants des principales associations professionnelles de l’école, notamment la Junior Entreprise (ESCP Europe conseil) 1 et ESCP Challenge 2 , ainsi qu’aux étudiants entrepreneurs de ESCP Europe. Inspiré du programme de la filière apprentissage, la BT offre aux membres de ces associations qui le souhaitent la possibilité de suivre sur l’ensemble de la première année de Master un cursus sur-mesure, aménagé en fonction de leurs obligations associatives et professionnelles, assorti d’un accompagnement personnalisé par un coach référent tout au long de l’année. Devant le succès de la première année test, la formule a été reconduite en septembre 2018 et ouverte à d’autres associations professionnelles de l’école.
Conversation avec un jeune entrepreneur qui dort dans la rue
Authors: Billion Julien
Published: December 2018

Les jeunes sans domicile ont vécu, le plus souvent, une rupture familiale et une trajectoire scolaire déviante : école buissonnière, exclusion des établissements scolaires, redoublements, abandon en cours de formation, obtention d’un diplôme peu valorisé, absence de diplôme. Leurs trajectoires professionnelles s’inscrivent, dans une certaine mesure, dans le prolongement de la trajectoire scolaire. Les épisodes sans domicile fragilisent le lien avec l’école et le travail et suscitent d’autres ruptures. Les jeunes vivant dans la rue sont soit chômeurs, soit travailleurs pauvres. Ils alternent des emplois légaux et illégaux et exercent des « petits boulots ». Certains choisissent, comme Pascal, de s’engager dans une forme d’entrepreneuriat via le statut de micro-entrepreneur. Dans l’entretien qui suit, Pascal, 29 ans, un jeune sans domicile fixe, se confie sur son rapport à la famille, à l’école, au travail, à l’entrepreneuriat.
Antécédents de pratique sportive intensive : comparaison entre patients souffrant de troubles liés à l’usage de substance et de trouble du comportement alimentaire
Authors: Fron Mathilde , Prétagut Stéphane , Cholet Jennyfer , Lambert Sylvain , Rousselet Morgane , Grall-Bronnec Marie
Published: December 2018

Plusieurs auteurs ont remarqué la fréquente association entre une pratique sportive excessive et la consommation de substances psychoactives ou la présence d’un trouble du comportement alimentaire. Cependant, aucune étude ne s’est intéressée à comparer ces deux types de patients vis-à-vis de leur pratique sportive. L’objectif de cette étude était d’étudier la prévalence des antécédents de pratique sportive intensive (définie par plus de 8 heures par semaine) et de caractériser la pratique sportive, chez les patients hospitalisés dans le service universitaire d’addictologie du Centre Hospitalier Universitaire de Nantes. L’étude a été proposée à deux types de patients (troubles liés à l’usage de substance psychoactive : groupe « SPA » et trouble du comportement alimentaire : groupe « TCA »), et le recueil des données a été réalisé par le biais d’un auto-questionnaire. Au total, 114 patients ont été inclus, 63 dans le groupe SPA et 51 dans le groupe TCA. Les antécédents de pratique sportive intensive étaient significativement plus fréquents dans le groupe TCA (52,94 %) que dans le groupe SPA (28,57 %) (p=0,008), ce qui était cohérent avec notre hypothèse initiale. Par ailleurs, la fréquence retrouvée dans le groupe SPA était similaire à celle retrouvée dans d’autres études. Cependant, les habitudes sportives n’étaient pas significativement différentes d’un groupe à l’autre. On pouvait en revanche souligner que la pratique sportive était plus problématique en termes de dommages dans le groupe TCA, même si ce ressenti était subjectif. Enfin, 30 à 50 % des patients estimaient que l’activité physique avait une influence positive vis-à-vis de leurs troubles, ce qui suggère que l’activité physique pourrait avoir un intérêt dans les soins en addictologie.
Hoofstuk 1: Griekse paleografie
Authors: Petzer J.H.
Published: December 2018

No abstract available.
Hoofstuk 2: Die bronne van die Nuwe Testament
Authors: Petzer J.H.
Published: December 2018

No abstract available.
Hoofstuk 8: Die rekonstruksie van die teksgeskiedenis
Authors: Petzer J.H.
Published: December 2018

No abstract available.
Chapter 8: The narrator's perspective on the temporal and topographic levels in Matthew's story
Authors: Van Aarde A.G.
Published: December 2018

No abstract available.
Chapter 9: Narrative point of view and the 'temporal' function of the Old Testament in Matthew's gospel
Authors: Van Aarde A.G.
Published: December 2018

No abstract available.
Chapter 4: A historical-critical classification of Jesus' parables and the metaphoric narration of the wedding feast in Matthew 22:1-14
Authors: Van Aarde A.G.
Published: December 2018

No abstract available.
Hoofstuk 1: Inleiding
Authors: Office Editorial
Published: December 2018

No abstract available.
Hoofstuk 5: Die Calvinisme in die beginjare
Authors: Pont A.D.
Published: December 2018

No abstract available.
Hoofstuk 9: Die Sinode van Dordrecht (1618-1619)
Authors: Pont A.D.
Published: December 2018

No abstract available.
Hoofstuk 10: Die Remonstrante
Authors: Pont A.D.
Published: December 2018

No abstract available.
Hoofstuk 16: Die nuwe Psalmberyming van 1775
Authors: Pont A.D.
Published: December 2018

No abstract available.
Bronne geraadpleeg
Authors: Pont A.D.
Published: December 2018

No abstract available.
Redaksioneel
Authors: Office Editorial
Published: December 2018

No abstract available.
'n Kritiese besinning oor die plek en samehang van die teologiese vakke in die Fakulteit Teologie van die Nederduitsch Hervormde Kerk van Afrika
Authors: Smith D.J.
Published: December 2018

No abstract available.
Acknowledgement to reviewers
Authors: Office Editorial
Published: December 2018

No abstract available.
Evaluation of the functional state of peach varieties (Prunus persica Mill.) when exposed hydrothermal stress to plants
Authors: Abilfazova Juliya , Belous Oksana
Published: December 2018

The article presents data on the change in the ratio of pigments and fluorescence of chlorophyll in peach leaves in the optimal period of vegetation and under hydrothermal stress. When determining the resistance of a peach to unfavorable environmental factors, methods based on laboratory, fixed changes in the physiological and biochemical processes occurring in plants are used. In the period of inadequate water availability, the water deficit in peach leaves increased to an average of 15%, while less stable - an increase in the parameter to 18% was observed. It is shown that the xeromorphic character of the leaf apparatus is associated with a slight change in the anatomical characteristics of the leaf (the thickness of the leaf blade before and after the drought), which determines the permanence of the turgor. In this case, in the leaves of resistant varieties, the loss of turgor is insignificant (LSD (p ≤0.05) = 7.24); the thickness of the leaf fluctuates within 0.20 mm. On the background of stress impact, a clear varietal difference was shown, which allowed us to develop a scale for a comparative assessment of the resistance of peach varieties and clones. During the active growth of the assimilation surface, an increase in the amount of green pigments in the leaves of experimental plants was noted. Perspective varieties of peach contain significantly higher amounts of chlorophylls compared to other varieties (LSD (p ≤0.05) = 0.30). Under unfavorable conditions, in these varieties the ratio of the sum of chlorophylls to carotenoids is higher, which is confirmed by their more developed adaptive potential. Reorganization of the pigmentary apparatus during the period of hydrothermal stress is accompanied by an increase in the coefficient of photosynthetic activity (Kf_n) and a decrease in the fluorescence level (F_T) of chlorophyll. Thus, the water deficit, pigment composition and fluorescence of chlorophyll make it possible to identify the resistance of peach varieties and clones to the action of hydrothermal stressors. Based on the results of the studies, the most resistant varieties and clones of peaches have been identified for the humid subtropics of Russia (Larisa, Early bloy, Medin red, Slavutich, Donetskij zheltij, Vanity and Form 1).
Extracranial and intracranial artery dissections: Experiences from a tertiary referral center
Authors: DENİZ Çiğdem , ASİL Talip , TUNÇ Abdulkadir
Published: December 2018

Background: Craniocervical artery dissection is an important cause of ischemic stroke especially in young and middle aged adults. In this study, we evaluated extracrainal and intracranial artery dissections in terms of etiologies, risk factors, stroke severity and functional outcomes. Methods: A total of 29 patients who were diagnosed with ischemic stroke due to extracranial or intracranial artery dissections were enrolled to this study. The ischemic stroke diagnosis was confirmed with diffusion weighted magnetic resonance imaging in all patients. Computed tomography angiography, magnetic resonance angiography and digital subtraction angiography were used to demonstrate the dissection. Demographic findings, risk factors and presence of trauma were evaluated. National Institute of Health Score Scale (NIHSS) was used for stroke severity assessment at disease onset. Functional outcomes were measured with Modified Rankin Scale (mRS) at the 3rd month. Results: Fifteen patients (51.72%) had carotid artery dissections while 12 patients (41.37%) had vertebral artery dissection (VAD), 1 (3.4%) had basilar artery dissection (BAD) and both VAD and BAD were seen in 1 patient (3.4%). Coagulopathy was detected in 12 patients (41.37%). Connective tissue disease was suspected in 3 patients (10.3%). In 6 patients, dissections occured after trauma. Nineteen patients (65.51%) presented with somatosensory deficits. The 3rd month mRS scores were in the range of 0-2 and no significant correlation was found in terms of risk factors, etiology and trauma history. Conclusion: Arterial dissection should be kept in mind for the clinical presentation of ischemic stroke in young adults. We think that better understanding of the risk factors, etiologies and clinical presentation of the dissections and early diagnosis-proper treatments might yield improved clinical outcomes.
In silico analysis of biomarker potentials of miRNA-mediated ceRNAs in prostate cancer
Authors: ERGÜN Sercan
Published: December 2018

Objective: The objective of this study is to define novel biomarkers for Prostate Cancer (PCa) via in silico analysis that takes PCa-specific miRNAs, finds their combinatorial target genes (potential ceRNAs), selects ones containing Transcribed Ultra Conserved Region (T-UCR) among them and potentiates their relevance with PCa. Methods: Thirty-four miRNAs of which clinical relevances with PCa were proved experimentally were exported via miRWalk database.Using the ComiR database, 859 genes targeted by these 34 miRNAs simultaneously were identified. Genes with ComiR score above 0.911 were taken into account. Genes containing T-UCR and showing potential ceRNA activity were extracted. Among PCa-associated ceRNAs including T-UCR, we identified genes with significant expression differences between PCa and normal prostate tissue using the GEPIA database. The statistical evaluation of the association of NFAT5 and PTBP2 genes with PCa was performed by Spearman correlation test in GEPIA database. Results: PCa-associated ceRNAs cross-matching with genes including T-UCR in their exonic regions were NFAT5, CLK3, PTBP2, CPEB4, MIPOL1 and TCF4. We identified genes with significant expression differences between PCa and normal prostate tissues among PCa-associated ceRNAs including T-UCR. According to this analysis, NFAT5 and PTBP2 genes were significantly less expressed in PCa than in normal prostate tissue while the others didn’t show any significant differential expression pattern. NFAT5 and PTBP2 genes were found to be significantly associated with PCa (p=0.000012; R=0.72). Conclusion: All in all, this is the study associating NFAT5 and PTBP2 genes with PCa and giving them tumor suppressive potential for PCa. Still, larger and more comprehensive studies are needed on this issue.
The health impact of (sexual) torture amongst Afghan, Iranian and Kurdish refugees: A literature review
Authors: Dehghan Roghieh
Published: December 2018

Background: Amongst Muslim majority countries, torture is reported most in Afghanistan and Iran. In addition, despite the significant impact of sexual violence on individuals and public health, the issue has been poorly researched amongst victims of torture. Objectives: The original intention of this paper was to review the health impact of sexual torture amongst Iranian and Afghan refugees in high-income countries; however, a comprehensive search of relevant databases did not produce any results. The aim of this review was then altered to examine those health-related studies that explored the impact of torture in this population. Special attention was given to the discussion of gender and sexual violence in those studies. Methodology: Web of Science, PILOTS, Medline, PsycINFO, Scopus, Popline and the online catalogue at DIGNITY were searched for health studies that examined the health impact or predictors of adverse health outcomes in Afghan, Iranian and Kurdish refugee survivors of torture. Outcome: Seven papers were identified and examined in this review. The results were limited by the diverse methodologies, by the use of psychiatric tools that had not been validated in this population, and by small sample sizes. Since there is a high prevalence of sexual torture in Iranian and Kurdish refugees, the issue merits greater attention in this population. Studies are most limited amongst the Afghan population. Moreover, there is a great need for further culture-andgender- specific health research in torture survivors from Muslim backgrounds.
Genocidal sexual assault on women and the role of culture in the rehabilitation process: Experiences from working with Yazidi women in Turkey
Authors: Yüksel Sahika , Saner Suzan , Basterzi Ayse Devrim , Oglagu Zerrin , Bülbül Israfil
Published: December 2018

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Violent Borders: Refugees and the Right to Move, by Reece Jones
Authors: Lemberg-Pedersen Martin
Published: December 2018

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Dose prescription with spatial uncertainty for peripheral lung SBRT
Authors: Bedford James L. , Blasiak‐Wal Irena , Hansen Vibeke N.
Published: December 2018

Current clinical practice is to prescribe to 95% of the planning target volume (PTV) in 4D stereotactic body radiotherapy (SBRT) for lung. Frequently the PTV margin has a very low physical density so that the internal target volume (ITV) receives an unnecessarily high dose. This study investigates the alternative of prescribing to the ITV while including the effects of positional uncertainties. Five patients were retrospectively studied with volumetric modulated arc therapy treatment plans. Five plans were produced for each patient: a static plan prescribed to PTV D95%, three probabilistic plans prescribed to ITV D95% and a static plan re‐prescribed to ITV D95% after inverse planning. For the three probabilistic plans, the scatter kernel in the dose calculation was convolved with a spatial uncertainty distribution consisting of either a uniform distribution extending ±5 mm in the three orthogonal directions, a distribution consisting of delta functions at ±5 mm, or a Gaussian distribution with standard deviation 5 mm. Median ITV D50% is 23% higher than the prescribed dose for static planning and only 10% higher than the prescribed dose for prescription to the ITV. The choice of uncertainty distribution has less than 2% effect on the median ITV dose. Re‐prescribing a static plan and evaluating with a probabilistic dose calculation results in a median ITV D95% which is 1.5% higher than when planning probabilistically. This study shows that a robust probabilistic approach to planning SBRT lung treatments results in the ITV receiving a dose closer to the intended prescription. The exact form of the uncertainty distribution is not found to be critical.
Aerobic α‐Oxidation of N‐Substituted Tetrahydroisoquinolines to Dihydroisoquinolones via Organo‐photocatalysis
Authors: Aganda Kim Christopher C. , Hong Boseok , Lee Anna
Published: December 2018

An efficient visible‐light‐induced α‐oxidation of N‐substituted tetrahydroisoquinolines to dihydroisoquinolones has been developed using eosin Y as an organo‐photocatalyst and oxygen as a green oxidant. The reactions were carried out under mild reaction conditions; the desired dihydroisoquinolones were obtained in up to 96% yield at room temperature under oxygen atmosphere. This transformation provides a convenient route to dihydroisoquinolones with a wide range of substrates.

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PiezoGRIN: A High‐Pressure Chamber Incorporating GRIN Lenses for High‐Resolution 3D‐Microscopy of living Cells and Tissues
Authors: Schneidereit Dominik , Schürmann Sebastian , Friedrich Oliver
Published: December 2018

A high‐pressure optical chamber, PiezoGRIN, that facilitates label‐free 3D high‐resolution live‐cell multiphoton microscopy in thick tissue samples is presented. A set of two Gradient Index (GRIN) rod lenses is integrated into the chamber as an optical guide and allows for the adjustment of the focal plane through the sample providing a field of view volume of 450 × 450 × 500 µm (x, y, z). An optical lateral resolution of 0.8 µm is achieved by using two‐photon excitation with 150 fs pulses of a 810 nm titanium–sapphire laser at hydrostatic pressures up to 200 MPa. With the PiezoGRIN setup, it is possible to follow pressure‐induced changes in subcellular structure of unstained vital mouse skeletal muscle tissue up to 200 µm below the tissue surface.
Potential‐Induced Fine‐Tuning of the Enantioaffinity of Chiral Metal Phases
Authors: Assavapanumat Sunpet , Yutthalekha Thittaya , Garrigue Patrick , Goudeau Bertrand , Lapeyre Véronique , Perro Adeline , Sojic Neso , Wattanakit Chularat , Kuhn Alexander
Published: December 2018

Concepts leading to single enantiomers of chiral molecules are of crucial importance for many applications, including pharmacology and biotechnology. Recently, mesoporous metal phases encoded with chiral information have been developed. Fine‐tuning of the enantioaffinity of such structures by imposing an electric potential is proposed, which can influence the electrostatic interactions between the chiral metal and the target enantiomer. This allows the binding affinity between the chiral metal and the target enantiomer to be increased, and thus, the discrimination between two enantiomers to be improved. The concept is illustrated by generating chiral encoded metals in a microfluidic channel by reduction of a platinum salt in the presence of a liquid crystal and l‐tryptophan as a chiral model template. After removal of the template molecules, the modified microchannel retains a pronounced chiral character. The chiral recognition efficiency of the microchannel can be fine‐tuned by applying a suitable potential to the metal phase. This enables the separation of both components of a racemate flowing through the channel. The approach constitutes a promising and complementary strategy in the frame of chiral discrimination technologies.
Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells
Authors: Ehret Janike , Zimmermann Martina , Eichhorn Thomas , Zimmer Aline
Published: December 2018

Glycosylation is a key critical quality attribute for monoclonal antibodies and other recombinant proteins because of its impact on effector mechanisms and half‐life. In this study, a variety of compounds were evaluated for their ability to modulate glycosylation profiles of recombinant monoclonal antibodies produced in Chinese hamster ovary cells. Compounds were supplemented into the cell culture feed of fed‐batch experiments performed with a CHO K1 and a CHO DG44 cell line expressing a recombinant immunoglobulin G1 (IgG1). Experiments were performed in spin tubes or the ambr®15 controlled bioreactor system, and the impact of the compounds at various concentrations was determined by monitoring the glycosylation profile of the IgG and cell culture parameters, such as viable cell density, viability, and titer. Results indicate that the highest impact on mannosylation was achieved through 15 µM kifunensine supplementation leading to an 85.8% increase in high‐mannose containing species. Fucosylation was reduced by 76.1% through addition of 800 µM 2‐F‐peracetyl fucose. An increase of 40.9% in galactosylated species was achieved through the addition of 120 mM galactose in combination with 48 µM manganese and 24 µM uridine. Furthermore, 6.9% increased sialylation was detected through the addition of 30 µM dexamethasone in combination with the same manganese, uridine, and galactose mixture used to increase total galactosylation. Further compounds or combinations of additives were also efficient at achieving a smaller overall glycosylation modulation, required, for instance, during the development of biosimilars. To the best of our knowledge, no evaluation of the efficacy of such a variety of compounds in the same cell culture system has been described. The studied cell culture media additives are efficient modulators of glycosylation and are thus a valuable tool to produce recombinant glycoproteins.
DEPArray™ system: An automatic image‐based sorter for isolation of pure circulating tumor cells
Authors: Di Trapani Mariano , Manaresi Nicolò , Medoro Gianni
Published: December 2018

Circulating tumor cells (CTCs) are rare cells shed into the bloodstream by invasive tumors and their analysis offers a promising noninvasive tool to predict and monitor therapeutic responses. CTCs can be isolated from patient blood and their characterization at single‐cell level can inform on the genomic landscape of a tumor. All CTC enrichment methods bear a burden of contaminating normal cells, which mandate a further step of purification to enable reliable downstream genetic analysis. Here, we describe the DEPArray™ technology, a microchip‐based digital sorter, which combines precise microfluidic and microelectronic enabling precise, image‐based isolation of single CTCs, which can then be analyzed by Next Generation Sequencing (NGS) methods. © 2018 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
The effects of food level and social density on reproduction in the Least Killifish, Heterandria formosa
Authors: Leatherbury Kathryn N. , Travis Joseph
Published: December 2018

The feedbacks from population density to demographic parameters, which drive population regulation, are the accumulated results of several ecological processes. The compensatory feedback from increased population density to fertility includes at least two distinct factors, the effects of decreases in per capita food level and increases in the social density (the number of interacting individuals). Because these effects have been studied separately, their relative importance is unknown. It is also unclear whether food limitation and social density combine additively to influence fertility. We investigated these questions with two factorial experiments on reproduction in the Least Killifish, Heterandria formosa. In one experiment, we crossed two levels of density with two levels of a total food ration that was distributed to all individuals. In the other experiment, we crossed two levels of density with two levels of per capita food. Whereas the first experiment suggested that the effects of variation in food level and density were synergistic, the second experiment indicated that they were not. The apparent synergism—the statistical interaction of food and density levels—was the result of confounding per capita food with social density in that design. In the second experiment, the effects of social density on reproductive rate were stronger than the effects of food level, whereas the effects of food level were stronger on offspring size at parturition than those of social density. The results suggest that the social stresses that emerge at higher densities play an important role in the compensatory response of fertility to density, a role, that is, at least as important as that of decreased per capita food levels.
Responses of macroalgae to CO2 enrichment cannot be inferred solely from their inorganic carbon uptake strategy
Authors: van der Loos Luna M. , Schmid Matthias , Leal Pablo P. , McGraw Christina M. , Britton Damon , Revill Andrew T. , Virtue Patti , Nichols Peter D. , Hurd Catriona L.
Published: December 2018

Increased plant biomass is observed in terrestrial systems due to rising levels of atmospheric CO2, but responses of marine macroalgae to CO2 enrichment are unclear. The 200% increase in CO2 by 2100 is predicted to enhance the productivity of fleshy macroalgae that acquire inorganic carbon solely as CO2 (non‐carbon dioxide‐concentrating mechanism [CCM] species—i.e., species without a carbon dioxide‐concentrating mechanism), whereas those that additionally uptake bicarbonate (CCM species) are predicted to respond neutrally or positively depending on their affinity for bicarbonate. Previous studies, however, show that fleshy macroalgae exhibit a broad variety of responses to CO2 enrichment and the underlying mechanisms are largely unknown. This physiological study compared the responses of a CCM species (Lomentaria australis) with a non‐CCM species (Craspedocarpus ramentaceus) to CO2 enrichment with regards to growth, net photosynthesis, and biochemistry. Contrary to expectations, there was no enrichment effect for the non‐CCM species, whereas the CCM species had a twofold greater growth rate, likely driven by a downregulation of the energetically costly CCM(s). This saved energy was invested into new growth rather than storage lipids and fatty acids. In addition, we conducted a comprehensive literature synthesis to examine the extent to which the growth and photosynthetic responses of fleshy macroalgae to elevated CO2 are related to their carbon acquisition strategies. Findings highlight that the responses of macroalgae to CO2 enrichment cannot be inferred solely from their carbon uptake strategy, and targeted physiological experiments on a wider range of species are needed to better predict responses of macroalgae to future oceanic change.
Regio‐ and stereoselective addition of trans‐Pt(TeAr)(SiMe3)(PEt3)2 to terminal alkynes leading to cis‐[(Z)‐β‐trimethylsilylalkenyl]platinum(II) complexes
Authors: Han Li‐Biao , Mirzaei Farzad , Shimada Shigeru
Published: December 2018

Selective insertion of terminal alkynes RC≡CH into the Si—Pt bond of trans‐Pt(TeAr)(SiMe3)(PEt3)2 took place readily to produce the corresponding novel alkenyl complexes cis‐Pt(TeAr)[(Z)‐CR=CHSiMe3](PEt3)2. The structure of the complex was characterized by an X‐ray analysis.
Smoking and papillomavirus DNA in patients with p16‐positive N3 oropharyngeal squamous cell carcinoma
Authors: Gorphe Philippe , Chekkoury Idrissi Younes , Tao Yungan , Moya‐Plana Antoine , Casiraghi Odile , Janot François , Blanchard Pierre , Mirghani Haïtham , Temam Stéphane
Published: December 2018

Background

We investigated the survival of patients with a p16‐positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics.

Methods

We retrospectively reviewed the data of patients treated at our Cancer Center for a p16‐positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression‐free survival (PFS).

Results

A total of 29 patients were included. The 5‐year OS and PFS were 67.5% and 59.1%, respectively. Smoking history above 10 pack‐years and the absence of human papillomavirus DNA were associated with worse OS (P = .02 and P = .03, respectively) and PFS (P = .02 and P = .02, respectively). Induction chemotherapy or radical neck dissection were not associated with different treatment outcomes.

Conclusion

Patients with an N3 p16‐positive oropharyngeal cancer in our series had a 5‐year OS rate of 67.5%. Smoking history and viral DNA were prognostic factors associated with survival.