bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Figure 6 from IKBKE Is a Substrate of EGFR and a Therapeutic Target in Non–Small Cell Lung Cancer with Activating Mutations of EGFR
Authors: Challa Sridevi , Guo Jian-Ping , Ding Xiaowen , Xu Cheng-Xiong , Li Yajuan , Kim Donghwa , Smith Matthew A. , Cress Douglas W. , Coppola Domenico , Haura Eric B. , Cheng Jin Q.
Published: April 2023

IKBKE inhibitor amlexanox induces G1 arrest and pERK
Supplemental Figure 2 from IKBKE Is a Substrate of EGFR and a Therapeutic Target in Non–Small Cell Lung Cancer with Activating Mutations of EGFR
Authors: Challa Sridevi , Guo Jian-Ping , Ding Xiaowen , Xu Cheng-Xiong , Li Yajuan , Kim Donghwa , Smith Matthew A. , Cress Douglas W. , Coppola Domenico , Haura Eric B. , Cheng Jin Q.
Published: April 2023

IKBKE interacts with EGFR.
Supplementary Table S1 from Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4–NDRG1 Axis
Authors: Verma Nandini , Müller Anna-Katharina , Kothari Charu , Panayotopoulou Effrosini , Kedan Amir , Selitrennik Michael , Mills Gordon B. , Nguyen Lan K. , Shin Sungyoung , Karn Thomas , Holtrich Uwe , Lev Sima
Published: April 2023

Supplementary Table 1. Microarray dataset accessions
Supplementary Figure S2 from Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4–NDRG1 Axis
Authors: Verma Nandini , Müller Anna-Katharina , Kothari Charu , Panayotopoulou Effrosini , Kedan Amir , Selitrennik Michael , Mills Gordon B. , Nguyen Lan K. , Shin Sungyoung , Karn Thomas , Holtrich Uwe , Lev Sima
Published: April 2023

Supplementary Figure 2. Analysis of PYK2 and EGFR gene expression in human breast cancer samples
Supplementary Figure Legends from Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4–NDRG1 Axis
Authors: Verma Nandini , Müller Anna-Katharina , Kothari Charu , Panayotopoulou Effrosini , Kedan Amir , Selitrennik Michael , Mills Gordon B. , Nguyen Lan K. , Shin Sungyoung , Karn Thomas , Holtrich Uwe , Lev Sima
Published: April 2023

Legends for supplementary figures
Supplementary Materials and Methods from Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion
Authors: Chen Hsin-Yu , Larson Peder E.Z. , Bok Robert A. , von Morze Cornelius , Sriram Renuka , Delos Santos Romelyn , Delos Santos Justin , Gordon Jeremy W. , Bahrami Naeim , Ferrone Marcus , Kurhanewicz John , Vigneron Daniel B.
Published: April 2023

Supplementary Materials and Methods that includes "Hyperpolarization of 13C-labelled compounds", "Histochemical analysis", "mRNA expression and enzyme activity analyses", "Compressed Sensing Reconstruction and Spectroscopic Peak Estimation".
Supplementary Figure 5 from αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor
Authors: Lu Huimin , Wang Tao , Li Jing , Fedele Carmine , Liu Qin , Zhang Jianzhong , Jiang Zhong , Jain Dhanpat , Iozzo Renato V. , Violette Shelia M. , Weinreb Paul H. , Davis Roger J. , Gioeli Daniel , FitzGerald Thomas J. , Altieri Dario C. , Languino Lucia R.
Published: April 2023

alphavbeta6 enhances AR transcriptional activity in LNCaP cells.
Supplementary Figure 4 from αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor
Authors: Lu Huimin , Wang Tao , Li Jing , Fedele Carmine , Liu Qin , Zhang Jianzhong , Jiang Zhong , Jain Dhanpat , Iozzo Renato V. , Violette Shelia M. , Weinreb Paul H. , Davis Roger J. , Gioeli Daniel , FitzGerald Thomas J. , Altieri Dario C. , Languino Lucia R.
Published: April 2023

Full-size scans of PSA and androgen receptor immunoblots shown in Figure 4.
Supplementary Table 7 from Integrative Genomic Analysis Identifies the Core Transcriptional Hallmarks of Human Hepatocellular Carcinoma
Authors: Allain Coralie , Angenard Gaëlle , Clément Bruno , Coulouarn Cédric
Published: April 2023

List of genes included in the core enrichment for each drug from the up- or down-regulated genes of the core human HCC signature.
Supplementary Table 6 from Integrative Genomic Analysis Identifies the Core Transcriptional Hallmarks of Human Hepatocellular Carcinoma
Authors: Allain Coralie , Angenard Gaëlle , Clément Bruno , Coulouarn Cédric
Published: April 2023

Connectivity map results of the core human HCC signature.
Supplementary Figure 1 from αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor
Authors: Lu Huimin , Wang Tao , Li Jing , Fedele Carmine , Liu Qin , Zhang Jianzhong , Jiang Zhong , Jain Dhanpat , Iozzo Renato V. , Violette Shelia M. , Weinreb Paul H. , Davis Roger J. , Gioeli Daniel , FitzGerald Thomas J. , Altieri Dario C. , Languino Lucia R.
Published: April 2023

Increased alphavbeta6 integrin and JNK expression and enhanced JNK nuclear localization in castrated mice.
Supplementary Figure 2 from Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations
Authors: Fu Yu , Jovelet Cécile , Filleron Thomas , Pedrero Marion , Motté Nelly , Boursin Yannick , Luo Yufei , Massard Christophe , Campone Mario , Levy Christelle , Diéras Véronique , Bachelot Thomas , Garrabey Julie , Soria Jean-Charles , Lacroix Ludovic , André Fabrice , Lefebvre Celine
Published: April 2023

Relation between number of ctDNA mutations and total number of somatic mutations.
Supplementary Movie S2 from An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer
Authors: Jin Cheng S. , Wada Hironobu , Anayama Takashi , McVeigh Patrick Z. , Hu Hsin Pei , Hirohashi Kentaro , Nakajima Takahiro , Kato Tatsuya , Keshavjee Shaf , Hwang David , Wilson Brian C. , Zheng Gang , Yasufuku Kazuhiro
Published: April 2023

In vivo prototype dual bright-field and fluorescence bronchoscope imaging of rabbit lung tumor at 48 h post-injection, showing bright field image on the left and fluorescence image on the right.
Supplementary Figure S1 from Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors
Authors: Sommer Anette , Kopitz Charlotte , Schatz Christoph A. , Nising Carl F. , Mahlert Christoph , Lerchen Hans-Georg , Stelte-Ludwig Beatrix , Hammer Stefanie , Greven Simone , Schuhmacher Joachim , Braun Manuela , Zierz Ruprecht , Wittemer-Rump Sabine , Harrenga Axel , Dittmer Frank , Reetz Frank , Apeler Heiner , Jautelat Rolf , Huynh Hung , Ziegelbauer Karl , Kreft Bertolt
Published: April 2023

The FGFR2-ADC BAY 1187982 inhibits microtubule polymerization resulting in induction of apoptosis.
Supplementary Materials and Method from Personalized Management of Pancreatic Ductal Adenocarcinoma Patients through Computational Modeling
Authors: Yamamoto Kimiyo N. , Yachida Shinichi , Nakamura Akira , Niida Atsushi , Oshima Minoru , De Subhajyoti , Rosati Lauren M. , Herman Joseph M. , Iacobuzio-Donahue Christine A. , Haeno Hiroshi
Published: April 2023

Supplementary Materials and Method
Supplementary Figure 3- LPS effects on the immune system are not restricted to D2A1-d cells from Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency
Authors: De Cock Jasmine M. , Shibue Tsukasa , Dongre Anushka , Keckesova Zuzana , Reinhardt Ferenc , Weinberg Robert A.
Published: April 2023

LPS-induced inflammation involves the native but not the adaptive immune system.
Supplementary Figure S1 from Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy
Authors: Ingle James N. , Xie Fang , Ellis Matthew J. , Goss Paul E. , Shepherd Lois E. , Chapman Judith-Anne W. , Chen Bingshu E. , Kubo Michiaki , Furukawa Yoichi , Momozawa Yukihide , Stearns Vered , Pritchard Kathleen I. , Barman Poulami , Carlson Erin E. , Goetz Matthew P. , Weinshilboum Richard M. , Kalari Krishna R. , Wang Liewei
Published: April 2023

Participant Flow Diagram for study.
Supplemental Figure Legend from Functional Flow Patterns and Static Blood Pooling in Tumors Revealed by Combined Contrast-Enhanced Ultrasound and Photoacoustic Imaging
Authors: Bar-Zion Avinoam , Yin Melissa , Adam Dan , Foster F. Stuart
Published: April 2023

Legend for Supplemental Figure S1.
Supplementary Materials from A Model-Based Personalized Cancer Screening Strategy for Detecting Early-Stage Tumors Using Blood-Borne Biomarkers
Authors: Hori Sharon Seiko , Lutz Amelie M. , Paulmurugan Ramasamy , Gambhir Sanjiv Sam
Published: April 2023

The Supplementary Materials contains the following: 1) Derivation of Model Steady State Conditions in the Absence of Cancer; 2) Validation of the 2-Compartment Model Structure in the Absence and Presence of Cancer; 3) Parameter Values and Model Assumptions for Simulating Cancer Patient Screening; 4) Supplementary Fig. S1 (Mathematical modeling of blood biomarker data can be used for personalized detection of aggressive disease and monitoring of non-aggressive disease); 5) Supplementary Fig. S2 (Comparing early tumor growth using in vivo FL bioluminescence following implantation of A2780-SEAP-FL-eGFP or non-transfected A2780 cells in the mouse ovary); 6) Supplementary Fig. S3 (Plasma SEAP levels correlate with tumor viability in vivo in a subcutaneous 293T xenograft mouse model); 7) Supplementary Fig. S4 (SEAP shedding rates in cell culture); 8) Supplementary Fig. S5 (Model validation by predicting tumor growth in a subset of mice not used for model fitting and parameter estimation); 9) Supplementary Fig. S6 (Predicted tumor growth parameters in clinically relevant validation study); 10) Supplementary Fig. S7 (Application of the mathematical model to personalized screening of patients with asymptomatic aggressive disease in the absence of technical (assay measurement) error); 11) Supplementary Fig. S8 (Application of the mathematical model to personalized screening of patients with asymptomatic moderately aggressive disease); 12) Supplementary Table S1 (Model State Variables); 13) Supplementary Table S2 (Model Parameters); 14) Supplementary Table S3 (Estimating cancer-specific biomarker shedding kinetics in living mice); 15) Supplementary Table S4 (Summary of Training Parameter Estimates for Model Validation Study)
Supplementary Table 1 from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
Authors: Fehringer Gordon , Kraft Peter , Pharoah Paul D. , Eeles Rosalind A. , Chatterjee Nilanjan , Schumacher Fredrick R. , Schildkraut Joellen M. , Lindström Sara , Brennan Paul , Bickeböller Heike , Houlston Richard S. , Landi Maria Teresa , Caporaso Neil , Risch Angela , Amin Al Olama Ali , Berndt Sonja I. , Giovannucci Edward L. , Grönberg Henrik , Kote-Jarai Zsofia , Ma Jing , Muir Kenneth , Stampfer Meir J. , Stevens Victoria L. , Wiklund Fredrik , Willett Walter C. , Goode Ellen L. , Permuth Jennifer B. , Risch Harvey A. , Reid Brett M. , Bezieau Stephane , Brenner Hermann , Chan Andrew T. , Chang-Claude Jenny , Hudson Thomas J. , Kocarnik Jonathan K. , Newcomb Polly A. , Schoen Robert E. , Slattery Martha L. , White Emily , Adank Muriel A. , Ahsan Habibul , Aittomäki Kristiina , Baglietto Laura , Blomquist Carl , Canzian Federico , Czene Kamila , dos-Santos-Silva Isabel , Eliassen A. Heather , Figueroa Jonine D. , Flesch-Janys Dieter , Fletcher Olivia , Garcia-Closas Montserrat , Gaudet Mia M. , Johnson Nichola , Hall Per , Hazra Aditi , Hein Rebecca , Hofman Albert , Hopper John L. , Irwanto Astrid , Johansson Mattias , Kaaks Rudolf , Kibriya Muhammad G. , Lichtner Peter , Liu Jianjun , Lund Eiliv , Makalic Enes , Meindl Alfons , Müller-Myhsok Bertram , Muranen Taru A. , Nevanlinna Heli , Peeters Petra H. , Peto Julian , Prentice Ross L. , Rahman Nazneen , Sanchez Maria Jose , Schmidt Daniel F. , Schmutzler Rita K. , Southey Melissa C. , Tamimi Rulla , Travis Ruth C. , Turnbull Clare , Uitterlinden Andre G. , Wang Zhaoming , Whittemore Alice S. , Yang Xiaohong R. , Zheng Wei , Buchanan Daniel D. , Casey Graham , Conti David V. , Edlund Christopher K. , Gallinger Steven , Haile Robert W. , Jenkins Mark , Le Marchand Loïc , Li Li , Lindor Noralene M. , Schmit Stephanie L. , Thibodeau Stephen N. , Woods Michael O. , Rafnar Thorunn , Gudmundsson Julius , Stacey Simon N. , Stefansson Kari , Sulem Patrick , Chen Y. Ann , Tyrer Jonathan P. , Christiani David C. , Wei Yongyue , Shen Hongbing , Hu Zhibin , Shu Xiao-Ou , Shiraishi Kouya , Takahashi Atsushi , Bossé Yohan , Obeidat Ma'en , Nickle David , Timens Wim , Freedman Matthew L. , Li Qiyuan , Seminara Daniela , Chanock Stephen J. , Gong Jian , Peters Ulrike , Gruber Stephen B. , Amos Christopher I. , Sellers Thomas A. , Easton Douglas F. , Hunter David J. , Haiman Christopher A. , Henderson Brian E. , Hung Rayjean J.
Published: April 2023

Variants selected for replication
Supplementary figure 8 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia
Authors: Chen Justin L. , Walton Kelly L. , Qian Hongwei , Colgan Timothy D. , Hagg Adam , Watt Matthew J. , Harrison Craig A. , Gregorevic Paul
Published: April 2023

Comparing the rate of lean and fat mass loss in mice bearing colon-26 tumors and mice injected with rAAV6:activin A and/or rAAV6:IL-6.
Supplementary figure 4 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia
Authors: Chen Justin L. , Walton Kelly L. , Qian Hongwei , Colgan Timothy D. , Hagg Adam , Watt Matthew J. , Harrison Craig A. , Gregorevic Paul
Published: April 2023

TA muscles of mice injected with rAAV6:TNF-α and rAAV6:Tweak exhibited muscle loss and increases in the phosphorylation of p65, but did not induce cachexia.
Supplementary Figures. from Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14
Authors: Du Yongxing , Liu Ziwen , You Lei , Hou Pengjiao , Ren Xiaoxia , Jiao Tao , Zhao Wenjing , Li Zongze , Shu Hong , Liu Changzheng , Zhao Yupei
Published: April 2023

10 supplementary figures are referenced in this manuscript. Fig.S1. The expression of NOP14 is positively correlated with the capacity of PDAC cells. Fig. S2. The expression of NOP14 is determined in PANC-1 cells. Fig. S3. NOP14 promotes MIA PaCa-2 cell migration and invasion in vitro. Fig. S4. The expression of NOP14 is determined in MIA PaCa-2 cells. Fig. S5. NOP14 inhibition leads to dampened capacity of invasion in PANC-1 cells. Fig. S6. The suppressive impact of si-p53 is analyzed in PDAC cells. Fig. S7. NOP14 promotes PDAC metastasis by regulating miR-17-5p expression. Fig. S8. miR-17-5p inhibits the luciferase activity of P21 reporter in MIA PaCa-2 cells. Fig. S9. The RNA stability of pri-miR-17-5p is evaluated in PDAC cells. Fig. S10. The impact of NOP14 on c-Myc expression is determined in PDAC cells.
Supplementary figure 2 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia
Authors: Chen Justin L. , Walton Kelly L. , Qian Hongwei , Colgan Timothy D. , Hagg Adam , Watt Matthew J. , Harrison Craig A. , Gregorevic Paul
Published: April 2023

mRNA expression of activin A and Il-6 in the TA muscle, heart, liver and spleen of mice bearing colon-26 tumors.
Supplemental Figure Legends from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia
Authors: Chen Justin L. , Walton Kelly L. , Qian Hongwei , Colgan Timothy D. , Hagg Adam , Watt Matthew J. , Harrison Craig A. , Gregorevic Paul
Published: April 2023

Legends
supplemental information from Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage
Authors: Wang Lintao , Chen Qian , Qi Haixia , Wang Chunming , Wang Cheng , Zhang Junfeng , Dong Lei
Published: April 2023

Supplemental informantion included partial data which verified that ET is a direact cause of the side efforts of DOX and data which verified that mTOR signaling pathway play a role in DOX-induced systemic inflammation.
Supplementary Fig. S2 from Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations
Authors: Kadariya Yuwaraj , Cheung Mitchell , Xu Jinfei , Pei Jianming , Sementino Eleonora , Menges Craig W. , Cai Kathy Q. , Rauscher Frank J. , Klein-Szanto Andres J. , Testa Joseph R.
Published: April 2023

Electropherograms of Bap1 PCR products of early passage tumor cells from two mice with asbestos-induced malignant mesotheliomas.
Table S4 from Tissue-Specific Signaling Networks Rewired by Major Somatic Mutations in Human Cancer Revealed by Proteome-Wide Discovery
Authors: Zhao Junfei , Cheng Feixiong , Zhao Zhongming
Published: April 2023

Gene list in consensus modules for each cancer type.
Table S3 from Tissue-Specific Signaling Networks Rewired by Major Somatic Mutations in Human Cancer Revealed by Proteome-Wide Discovery
Authors: Zhao Junfei , Cheng Feixiong , Zhao Zhongming
Published: April 2023

Full list of significantly mutated proteins (SMPs) of pan-cancer and each cancer type.
Supplemental Table S1 from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma
Authors: Li Huaibiao , Frappart Lucien , Moll Jürgen , Winkler Anne , Kroll Torsten , Hamann Jana , Kufferath Iris , Groth Marco , Taudien Stefan , Schütte Moritz , Yaspo Marie-Laure , Heuer Heike , Lange Bodo M.H. , Platzer Matthias , Zatloukal Kurt , Herrlich Peter , Ploubidou Aspasia
Published: April 2023

Overview of human testis biopsy samples, which were analyzed for RHAMM parameters (mRNA expression, protein localization, locus variants, allele frequencies) as well as for expression of CFIm25 and of 12 TGCT susceptibility genes.
Figure S2 from Tissue-Specific Signaling Networks Rewired by Major Somatic Mutations in Human Cancer Revealed by Proteome-Wide Discovery
Authors: Zhao Junfei , Cheng Feixiong , Zhao Zhongming
Published: April 2023

Survival analysis by comparing the 25% highly expressed patients with the 25% lowly expressed patients.
Supplementary Figures and Legends from Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ
Authors: Davis Ruth J. , Moore Ellen C. , Clavijo Paul E. , Friedman Jay , Cash Harrison , Chen Zhong , Silvin Chris , Van Waes Carter , Allen Clint
Published: April 2023

The supplemental figures demonstrate data supportive of the overall conclusions of this manuscript including MDSC flow cytometry gating strategy, evidence for moderate suppression of peripheral MDSC T-lymphocyte suppressive capacity after IPI-145 monotherapy, evidence that combination IPI-145 and PD-L1 mAb do not alter tumor MDSC infiltration, and results suggesting that IPI-145 alone or in combination with PD-L1 mAb does not alter the growth phenotype of poorly immunogenic MOC2 tumors.
Supplemental Figure S2 from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma
Authors: Li Huaibiao , Frappart Lucien , Moll Jürgen , Winkler Anne , Kroll Torsten , Hamann Jana , Kufferath Iris , Groth Marco , Taudien Stefan , Schütte Moritz , Yaspo Marie-Laure , Heuer Heike , Lange Bodo M.H. , Platzer Matthias , Zatloukal Kurt , Herrlich Peter , Ploubidou Aspasia
Published: April 2023

The truncated RHAMM-âˆ†C protein retains its microtubule binding capacity.
Supplementary Figures 1 through 7 and Supplementary Table 1 from Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model
Authors: Thiem Stefan , Eissmann Moritz F. , Elzer Joachim , Jonas Anna , Putoczki Tracy L. , Poh Ashleigh , Nguyen Paul , Preaudet Adele , Flanagan Dustin , Vincan Elizabeth , Waring Paul , Buchert Michael , Jarnicki Andrew , Ernst Matthias
Published: April 2023

Additional supportive data is provided as Fig S1 (Generation and validation of Tg(Tff1-CreERT2)mice), Fig. S2 (Tff1-CreERT2 transgene, endogenous Tff1, and Lgr5 expression in the stomach), Fig. S3 (Tff1-CreERT2-mediated I2-galactosidase reporter activity in various organs), Fig. S4 (KrasG12D-induced gastric tumorigenesis is associated with aberrant mucous production, ectopic expression of intestinal genes and immune cell infiltration), Fig. S5 (Gastric-specific activation of oncogenic BrafV600E triggers tumorigenesis associated with increased Erk and Stat3 phosphorylation), Fig. S6 (Tff1-CreERT2 activity in established gastric tumors of gp130F/F mice), Fig. S7 (Co-activation of Kras and gp130 signalling induces intestinalization associated with severe atrophy) and Table S1 (Incidence and onset of gastric tumor formation).
Supplementary Figure Legends from Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model
Authors: Thiem Stefan , Eissmann Moritz F. , Elzer Joachim , Jonas Anna , Putoczki Tracy L. , Poh Ashleigh , Nguyen Paul , Preaudet Adele , Flanagan Dustin , Vincan Elizabeth , Waring Paul , Buchert Michael , Jarnicki Andrew , Ernst Matthias
Published: April 2023

Supplementary Figure Legends
Supplemental Methods from Stromal-Based Signatures for the Classification of Gastric Cancer
Authors: Uhlik Mark T. , Liu Jiangang , Falcon Beverly L. , Iyer Seema , Stewart Julie , Celikkaya Hilal , O'Mahony Marguerita , Sevinsky Christopher , Lowes Christina , Douglass Larry , Jeffries Cynthia , Bodenmiller Diane , Chintharlapalli Sudhakar , Fischl Anthony , Gerald Damien , Xue Qi , Lee Jee-yun , Santamaria-Pang Alberto , Al-Kofahi Yousef , Sui Yunxia , Desai Keyur , Doman Thompson , Aggarwal Amit , Carter Julia H. , Pytowski Bronislaw , Jaminet Shou-ching , Ginty Fiona , Nasir Aejaz , Nagy Janice A. , Dvorak Harold F. , Benjamin Laura E.
Published: April 2023

This file contains details too lengthy to put in the primary manuscript file as well as methods for supplemental data
Supplementary Table S1 from Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth
Authors: Haesen Dorien , Abbasi Asbagh Layka , Derua Rita , Hubert Antoine , Schrauwen Stefanie , Hoorne Yana , Amant Frédéric , Waelkens Etienne , Sablina Anna , Janssens Veerle
Published: April 2023

Overview of PPP2R1A mutations found in gynaecological cancers.
Table S3. Association of TF scores with relapse-free survival. from Morphoproteomic Characterization of Lung Squamous Cell Carcinoma Fragmentation, a Histological Marker of Increased Tumor Invasiveness
Authors: Casanova Ruben , Xia Daniel , Rulle Undine , Nanni Paolo , Grossmann Jonas , Vrugt Bart , Wettstein Reto , Ballester-Ripoll Rafael , Astolfo Alberto , Weder Walter , Moch Holger , Stampanoni Marco , Beck Andrew H. , Soltermann Alex
Published: April 2023

Survival analysis for human-based TF scores by univariate and multivariate cox regressions. RFS=relapse-free survival; CI=95% confidence interval; Computer: automatic scoring on pan-cytokeratin stained tissue; Human: fragmentation scored by eye; TF (low/high): scores dichotomized at the median (categorical); TF (continuous): score as continuous variable.
Figure S2. Threshold analysis of tumor fragmentation in correlation with RFS and OS. from Morphoproteomic Characterization of Lung Squamous Cell Carcinoma Fragmentation, a Histological Marker of Increased Tumor Invasiveness
Authors: Casanova Ruben , Xia Daniel , Rulle Undine , Nanni Paolo , Grossmann Jonas , Vrugt Bart , Wettstein Reto , Ballester-Ripoll Rafael , Astolfo Alberto , Weder Walter , Moch Holger , Stampanoni Marco , Beck Andrew H. , Soltermann Alex
Published: April 2023

Series of cox univariate survival analyses are represented for the WS cohort. Data points represent single survival analyses repeated for computed TF scores using different tumor fragments size cut-offs. X-axis indicates the minimal size threshold for tumor fragments. Y-axis are the corresponding p-values. Black line indicates p=0.05.
Supplementary Table 1 from Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells
Authors: Gabai Vladimir L. , Yaglom Julia A. , Wang Yongmei , Meng Le , Shao Hao , Kim Geunwon , Colvin Teresa , Gestwicki Jason , Sherman Michael Y.
Published: April 2023

Table S1. Results of Gene Sets Enrichment analysis of motility genes downregulated by JG-98.
Supplemental methods and materials from Targetable T-type Calcium Channels Drive Glioblastoma
Authors: Zhang Ying , Cruickshanks Nichola , Yuan Fang , Wang Baomin , Pahuski Mary , Wulfkuhle Julia , Gallagher Isela , Koeppel Alexander F. , Hatef Sarah , Papanicolas Christopher , Lee Jeongwu , Bar Eli E. , Schiff David , Turner Stephen D. , Petricoin Emanuel F. , Gray Lloyd S. , Abounader Roger
Published: April 2023

Supplementary methods containing descriptions of PCR primer sequences, Reverse Phase Protein Arrays, RNA-seq, and Rescue Experiments.
Supplementary Materials and Methods, Supplementary Figures 1 through 8, and Supplementary Table 1 from Mechanisms through Which Hypoxia-Induced Caveolin-1 Drives Tumorigenesis and Metastasis in Hepatocellular Carcinoma
Authors: Mao Xiaowen , Wong Sivia Yuen Sze , Tse Edith Yuk Ting , Ko Frankie Chi Fat , Tey Sze Keong , Yeung Yin Shan , Man Kwan , Lo Regina Cheuk-Lam , Ng Irene Oi-Lin , Yam Judy Wai Ping
Published: April 2023

Supplementary Fig. 1. Transcriptional upregulation of Cav1 expression by HIF-1α in HCC cells under hypoxia. Supplementary Fig. 2. Cav1 expression is regulated by HIF1α and is HIF2 independent. Supplementary Fig. 3. Hypoxia promotes HCC cell motility and invasiveness in vitro. Supplementary Fig. 4. Hypoxia promotes HCC metastasis in animal model. Supplementary Fig. 5. Validation of S100P expression in Cav1 knockdown stable clones. Supplementary Fig. 6. Restoration of S100P expression in Cav1 stable knockdown clones. Supplementary Fig. 7. Analysis of sh-8001/S100P cells using orthotopic liver implantation subjected to hepatic artery ligation (HAL). Supplementary Fig. 8. Expression of S100P in stable knockdown clones. Supplementary Table 1. Deregulation of genes determined by microarray profiles of paired non-target control (sh-Ctl) and Cavl knockdown cells (sh-8001) with fold change greater than 2.
Figure S3 from Individualized Breast Cancer Characterization through Single-Cell Analysis of Tumor and Adjacent Normal Cells
Authors: Anjanappa Manjushree , Cardoso Angelo , Cheng Lijun , Mohamad Safa , Gunawan Andrea , Rice Susan , Dong Yan , Li Lang , Sandusky George E. , Srour Edward F. , Nakshatri Harikrishna
Published: April 2023

Figure S3 shows unsupervised clustering of stemless genes in all cell types examined in patient 1
Supplemental Figures and Tables from An Ex Vivo Platform for the Prediction of Clinical Response in Multiple Myeloma
Authors: Silva Ariosto , Silva Maria C. , Sudalagunta Praneeth , Distler Allison , Jacobson Timothy , Collins Aunshka , Nguyen Tuan , Song Jinming , Chen Dung-Tsa , Chen Lu , Cubitt Christopher , Baz Rachid , Perez Lia , Rebatchouk Dmitri , Dalton William , Greene James , Gatenby Robert , Gillies Robert , Sontag Eduardo , Meads Mark B. , Shain Kenneth H.
Published: April 2023

Supplemental Figures and Tables to augment (1) the mathematical modeling (providing details on specific therapeutics); (2) patient characteristics (treatment history, clinical and predicted response), (3) synergistic activities identified by EMMA; and (4) data processing guides
Supplemental Table S1 from EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition
Authors: Hsu Ya-Ting , Osmulski Pawel , Wang Yao , Huang Yi-Wen , Liu Lu , Ruan Jianhua , Jin Victor X. , Kirma Nameer B. , Gaczynska Maria E. , Huang Tim Hui-Ming
Published: April 2023

List of primer sequences
Supplementary Figures from Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment
Authors: Gomez-Chou Sobeyda B. , Swidnicka-Siergiejko Agnieszka Katarzyna , Badi Niharika , Chavez-Tomar Myrriah , Lesinski Gregory B. , Bekaii-Saab Tanios , Farren Matthew R. , Mace Thomas A. , Schmidt Carl , Liu Yan , Deng Defeng , Hwang Rosa F. , Zhou Liran , Moore Todd , Chatterjee Deyali , Wang Huamin , Leng Xiaohong , Arlinghaus Ralph B. , Logsdon Craig D. , Cruz-Monserrate Zobeida
Published: April 2023

Figure S1. LCN2 plasma levels do not correlated with BMI of patients with metastatic PDAC. Figure S2. Lcn2 and SLC22A17 expression in SVF from mice. Figure S3. Lcn2 expression is depleted in Lcn2-/-/KRasG12D/CRE animals and experience lower changes in body weight and effects of caerulein treatments in mice with and without Lcn2 expression. Figure S4. KPC-LUC cells expressed higher levels of Lcn2 compared to normal pancreas from wild type mice. Figure S5. KPC-LUC cells injected in the pancreas do not survive in all Lcn2-/- mice. Figure S6. Lcn2 depletion attenuates ECM remodeling, immune infiltration and tumor cell proliferation in Lcn2 null mice with tumors and invasion of peritoneal macrophages was not impaired in Lcn2 null mice. Figure S7. Lcn2 null mice expressed lower levels of the Lcn2 receptor SLC22A17. Figure S8. LCN2 induces a pro-inflammatory response in PSCs that is reduced after downregulation of the SLC22A17 receptor. Figure S9. SLC22A17 expression in adipose tissue from mice.
Supplementary Figures 1 through 3 from RPL23 Links Oncogenic RAS Signaling to p53-Mediated Tumor Suppression
Authors: Meng Xuan , Tackmann Nicole R. , Liu Shijie , Yang Jing , Dong Jiahong , Wu Congying , Cox Adrienne D. , Zhang Yanping
Published: April 2023

The supplemental file contains three supplemental figures (Figures S1-S3), their figure legends and additional methods not included in the manuscript. Figure S1 shows hematoxylin and eosin (H&E) staining of tumor free skin and melanomas from mice of all genotypes to demonstrate that the MDM2C305F mutation does not affect the pathophysiology of oncogenic RAS overexpression-induced tumorigenesis. Figure S2 is complementary to Figure 2 in the manuscript. It provides mRNA and protein expression of RPL23 and RPL11 in additional genotypes of mouse and MEFs. We tested RPL23 and RPL11 expression in response to RAS overexpression and MDM2C305F mutation. Additionally, Figures S2G-H show the raw data that is summarized in Figure 2J, and Figure S2I shows a summary of RPL11 half-life from the raw data in Figure S2G-H. This figure supports the notion that RPL23 mRNA and protein levels increase in response to RAS and MDM2C305F mutation and show that protein stability is unchanged in Mdm2m/m MEFs. Figure S3 is complementary to Figure 3 in the manuscript. These data show that the upregulation of RPL23 in response to RAS is conserved in a human cell line (HEK-293).
Supplemental Table 1 from Detection of an Immunogenic HERV-E Envelope with Selective Expression in Clear Cell Kidney Cancer
Authors: Cherkasova Elena , Scrivani Claire , Doh Susan , Weisman Quinn , Takahashi Yoshiyuki , Harashima Nanae , Yokoyama Hisayuki , Srinivasan Ramaprasad , Linehan W. Marston , Lerman Michael I. , Childs Richard W.
Published: April 2023

The data of qPCR of cDNA from normal tissues using CT-RCC-Env and CT-RCC-8 specific primers are shown as copies of CT-RCC-Env and CT-RCC-8 transcripts relative to GAPDH X10<5/sup> .
Supplementary Methods from Regeneration of CD8αβ T Cells from T-cell–Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity
Authors: Maeda Takuya , Nagano Seiji , Ichise Hiroshi , Kataoka Keisuke , Yamada Daisuke , Ogawa Seishi , Koseki Haruhiko , Kitawaki Toshio , Kadowaki Norimitsu , Takaori-Kondo Akifumi , Masuda Kyoko , Kawamoto Hiroshi
Published: April 2023

Supplementary Methods
Supplementary Figure Legends from Regeneration of CD8αβ T Cells from T-cell–Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity
Authors: Maeda Takuya , Nagano Seiji , Ichise Hiroshi , Kataoka Keisuke , Yamada Daisuke , Ogawa Seishi , Koseki Haruhiko , Kitawaki Toshio , Kadowaki Norimitsu , Takaori-Kondo Akifumi , Masuda Kyoko , Kawamoto Hiroshi
Published: April 2023

Supplementary Figure Legends
Supplementary Table 3 from Integrative Cancer Pharmacogenomics to Infer Large-Scale Drug Taxonomy
Authors: El-Hachem Nehme , Gendoo Deena M.A. , Ghoraie Laleh Soltan , Safikhani Zhaleh , Smirnov Petr , Chung Christina , Deng Kenan , Fang Ailsa , Birkwood Erin , Ho Chantal , Isserlin Ruth , Bader Gary D. , Goldenberg Anna , Haibe-Kains Benjamin
Published: April 2023

Drug communities identified from the DNF taxonomies.
Supplementary Table S1 from Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process
Authors: Ohba Shigeo , Mukherjee Joydeep , Johannessen Tor-Christian , Mancini Andrew , Chow Tracy T. , Wood Matthew , Jones Lindsey , Mazor Tali , Marshall Roxanne E. , Viswanath Pavithra , Walsh Kyle M. , Perry Arie , Bell Robert J.A. , Phillips Joanna J. , Costello Joseph F. , Ronen Sabrina M. , Pieper Russell O.
Published: April 2023

SNVs identified by exome-sequencing.
Supplementary Table 1 from Activation of NOTCH Signaling by Tenascin-C Promotes Growth of Human Brain Tumor-Initiating Cells
Authors: Sarkar Susobhan , Mirzaei Reza , Zemp Franz J. , Wei Wu , Senger Donna L. , Robbins Stephen M. , Yong V. Wee
Published: April 2023

This supplementary data of microarray information contains results that support the tenascin C to notch pathway highlighted in this manuscript
Supplementary Materials and Methods from Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer
Authors: Oddo Daniele , Sennott Erin M. , Barault Ludovic , Valtorta Emanuele , Arena Sabrina , Cassingena Andrea , Filiciotto Genny , Marzolla Giulia , Elez Elena , van Geel Robin M.J.M. , Bartolini Alice , Crisafulli Giovanni , Boscaro Valentina , Godfrey Jason T. , Buscarino Michela , Cancelliere Carlotta , Linnebacher Michael , Corti Giorgio , Truini Mauro , Siravegna Giulia , Grasselli Julieta , Gallicchio Margherita , Bernards René , Schellens Jan H.M. , Tabernero Josep , Engelman Jeffrey A. , Sartore-Bianchi Andrea , Bardelli Alberto , Siena Salvatore , Corcoran Ryan B. , Di Nicolantonio Federica
Published: April 2023

The file lists Supplementary Materials and Methods and relative References.
Supplementary Materials and Methods and Supplementary Figure Legends from Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer
Authors: Xing Fei , Liu Yin , Sharma Sambad , Wu Kerui , Chan Michael D. , Lo Hui-Wen , Carpenter Richard L. , Metheny-Barlow Linda J. , Zhou Xiaobo , Qasem Shadi A. , Pasche Boris , Watabe Kounosuke
Published: April 2023

Supplementary Figure S1. GSEA results of selected pathways. Supplementary Figure S2. c-Met expression in clinical samples and brain metastatic cells. Supplementary Figure S3. Knockdown of c-Met suppresses IL1beta, IL8 and CXCL1 expressions in brain metastatic cells. Supplementary Figure S4. c-Met signaling induces IL1β, IL8 and CXCL1. Supplementary Figure S5. MTS assay of HBMEC. Supplementary Figure S6. Activation of tumor associated astrocytes by tumor cells. Supplementary Figure S7. PTER suppresses brain metastasis by targeting c-Met induced inflammation.
Supplementary Figure S5 from Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation
Authors: Schwartz Hila , Blacher Eran , Amer Malak , Livneh Nir , Abramovitz Lilach , Klein Anat , Ben-Shushan Dikla , Soffer Shelly , Blazquez Raquel , Barrantes-Freer Alonso , Müller Meike , Müller-Decker Karin , Stein Reuven , Tsarfaty Galia , Satchi-Fainaro Ronit , Umansky Viktor , Pukrop Tobias , Erez Neta
Published: April 2023

Supplementary Figure S5: Melanoma-derived transcripts can be found in CSF isolated from intracardiac injected mice
Supplementary Figure S1 from Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation
Authors: Schwartz Hila , Blacher Eran , Amer Malak , Livneh Nir , Abramovitz Lilach , Klein Anat , Ben-Shushan Dikla , Soffer Shelly , Blazquez Raquel , Barrantes-Freer Alonso , Müller Meike , Müller-Decker Karin , Stein Reuven , Tsarfaty Galia , Satchi-Fainaro Ronit , Umansky Viktor , Pukrop Tobias , Erez Neta
Published: April 2023

Supplementary Figure S1: Spontaneous brain macrometastases analyzed by MRI or histology
Supplementary Figure Legends from Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation
Authors: Schwartz Hila , Blacher Eran , Amer Malak , Livneh Nir , Abramovitz Lilach , Klein Anat , Ben-Shushan Dikla , Soffer Shelly , Blazquez Raquel , Barrantes-Freer Alonso , Müller Meike , Müller-Decker Karin , Stein Reuven , Tsarfaty Galia , Satchi-Fainaro Ronit , Umansky Viktor , Pukrop Tobias , Erez Neta
Published: April 2023

Supplementary figure legends
Supplemental Figure Legends from Response Heterogeneity of EGFR and HER2 Exon 20 Insertions to Covalent EGFR and HER2 Inhibitors
Authors: Kosaka Takayuki , Tanizaki Junko , Paranal Raymond M. , Endoh Hideki , Lydon Christine , Capelletti Marzia , Repellin Claire E. , Choi Jihyun , Ogino Atsuko , Calles Antonio , Ercan Dalia , Redig Amanda J. , Bahcall Magda , Oxnard Geoffrey R. , Eck Michael J. , Jänne Pasi A.
Published: April 2023

Figure legends for all supplemental figures
Table S2 from Immune Gene Expression Is Associated with Genomic Aberrations in Breast Cancer
Authors: Safonov Anton , Jiang Tingting , Bianchini Giampaolo , Győrffy Balázs , Karn Thomas , Hatzis Christos , Pusztai Lajos
Published: April 2023

Gene memberships of the 13 immune metagenes.
Supplementary Tables 1 through 4 from miR-9 and miR-200 Regulate PDGFRβ-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer
Authors: D'Ippolito Elvira , Plantamura Ilaria , Bongiovanni Lucia , Casalini Patrizia , Baroni Sara , Piovan Claudia , Orlandi Rosaria , Gualeni Ambra V. , Gloghini Annunziata , Rossini Anna , Cresta Sara , Tessari Anna , De Braud Filippo , Di Leva Gianpiero , Tripodo Claudio , Iorio Marilena V.
Published: April 2023

The file contains all the supplementary tables (S1-S4): - Supplementary Table S1. Clinicopathologic features of 78 breast cancer patients (set 1) and 85 TNBC (set 2). - Supplementary Table S2. Relation between miR-9 expression and clinicopathologic characteristics in human breast cancer. - Supplementary Table S3. Top 40 genes predicted as miR-9 target and statistically significant down-modulated in basal versus luminal breast cancer. - Supplementary Table S4. Relation between clinicopathologic characteristics and miR-9 and miR-200c in TNBC human tissues.
Supplementary Figure legends from miR-9 and miR-200 Regulate PDGFRβ-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer
Authors: D'Ippolito Elvira , Plantamura Ilaria , Bongiovanni Lucia , Casalini Patrizia , Baroni Sara , Piovan Claudia , Orlandi Rosaria , Gualeni Ambra V. , Gloghini Annunziata , Rossini Anna , Cresta Sara , Tessari Anna , De Braud Filippo , Di Leva Gianpiero , Tripodo Claudio , Iorio Marilena V.
Published: April 2023

Supplementary Figure legends (S1-S4)
Table S2 from Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon
Authors: Dermadi Denis , Valo Satu , Ollila Saara , Soliymani Rabah , Sipari Nina , Pussila Marjaana , Sarantaus Laura , Linden Jere , Baumann Marc , Nyström Minna
Published: April 2023

Table S2. List of animals used in specific analyzes in this study and summary of pathological reports
Supplementary Figure S5 from Enhanced Detection of Cancer Biomarkers in Blood-Borne Extracellular Vesicles Using Nanodroplets and Focused Ultrasound
Authors: Paproski Robert J. , Jovel Juan , Wong Gane Ka-Shu , Lewis John D. , Zemp Roger J.
Published: April 2023

Effect of ultrasound / nanodroplets on tumor cell viability via TUNEL staining.
Supplementary Table 1 from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature
Authors: Gilles Maud-Emmanuelle , Maione Federica , Cossutta Mélissande , Carpentier Gilles , Caruana Laure , Di Maria Silvia , Houppe Claire , Destouches Damien , Shchors Ksenya , Prochasson Christopher , Mongelard Fabien , Lamba Simona , Bardelli Alberto , Bouvet Philippe , Couvelard Anne , Courty José , Giraudo Enrico , Cascone Ilaria
Published: April 2023

Proteome array analysis of angiogenic molecules secreted by ECs.
Supplementary Materials and Methods and Supplementary Figure Legends from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature
Authors: Gilles Maud-Emmanuelle , Maione Federica , Cossutta Mélissande , Carpentier Gilles , Caruana Laure , Di Maria Silvia , Houppe Claire , Destouches Damien , Shchors Ksenya , Prochasson Christopher , Mongelard Fabien , Lamba Simona , Bardelli Alberto , Bouvet Philippe , Couvelard Anne , Courty José , Giraudo Enrico , Cascone Ilaria
Published: April 2023

The Supplementary data contains the methods and the Supplementary figure legends
Supplementary Figure 3 from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature
Authors: Gilles Maud-Emmanuelle , Maione Federica , Cossutta Mélissande , Carpentier Gilles , Caruana Laure , Di Maria Silvia , Houppe Claire , Destouches Damien , Shchors Ksenya , Prochasson Christopher , Mongelard Fabien , Lamba Simona , Bardelli Alberto , Bouvet Philippe , Couvelard Anne , Courty José , Giraudo Enrico , Cascone Ilaria
Published: April 2023

mPDAC orthopic model characterization.
Supplemental Table 2 from Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis
Authors: Murphy Brendan , Yin Han , Maris John M. , Kolb E. Anders , Gorlick Richard , Reynolds C. Patrick , Kang Min H. , Keir Stephen T. , Kurmasheva Raushan T. , Dvorchik Igor , Wu Jianrong , Billups Catherine A. , Boateng Nana , Smith Malcolm A. , Lock Richard B. , Houghton Peter J.
Published: April 2023

Objective Response Rates (ORR) for 67 Studies Based on Single Mouse Predictions of Group Median Response (2016 determinations).
Supplemental Figures from TWIST1-WDR5-Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis
Authors: Malek Reem , Gajula Rajendra P. , Williams Russell D. , Nghiem Belinda , Simons Brian W. , Nugent Katriana , Wang Hailun , Taparra Kekoa , Lemtiri-Chlieh Ghali , Yoon Arum R. , True Lawrence , An Steven S. , DeWeese Theodore L. , Ross Ashley E. , Schaeffer Edward M. , Pienta Kenneth J. , Hurley Paula J. , Morrissey Colm , Tran Phuoc T.
Published: April 2023

This document contains supplemental details such as antibodies and primers, list of genes overrepresented in TWIST1 and TWIST1 mutants, IHC staining for TWIST1 in mouse prostate development, IHC staining for TWIST1 and HOXA9 in various mouse models of prostate cancer, correlation of TWIST1 and HOXA9 alteration with poor survival in human prostate cancer patients, IHC for TWIST1 and HOXA9 on primary tumors and bone metastasis from prostate cancer patients, IHC for HOXA9 on cell pellets expressing HOXA9 or control and on adult mouse prostate, data showing sufficiency of HOXA9 for some pro-metastatic behaviour in prostate cancer cells, data showing requirement of WDR5 and HOTTIP for TWIST1-dependent pro-metastatic behavior, ChIP data showing binding of TWIST1 and HOXA9 at the HOXA9 promoter, data showing effect of drugs that can inhibit HOXA9 on prostate cancer cell viability and pro metastatic behaviour.
Suppl Info from BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer
Authors: Yokoyama Yuhki , Zhu Hengrui , Lee Jeong Heon , Kossenkov Andrew V. , Wu Sherry Y. , Wickramasinghe Jayamanna M. , Yin Xiangfan , Palozola Katherine C. , Gardini Alessandro , Showe Louise C. , Zaret Kenneth S. , Liu Qin , Speicher David , Conejo-Garcia Jose R. , Bradner James E. , Zhang Zhiguo , Sood Anil K. , Ordog Tamas , Bitler Benjamin G. , Zhang Rugang
Published: April 2023

Suppl Methods and Figure Legend
Supplementary Table S2 from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells
Authors: Kaur Amanpreet , Denisova Oxana V. , Qiao Xi , Jumppanen Mikael , Peuhu Emilia , Ahmed Shafiq U. , Raheem Olayinka , Haapasalo Hannu , Eriksson John , Chalmers Anthony J. , Laakkonen Pirjo , Westermarck Jukka
Published: April 2023

List of indolocarbazole staurosporine analogues, their primary target proteins, and status in the clinical trials for the indicated diseases.
Figure S3 from BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer
Authors: Yokoyama Yuhki , Zhu Hengrui , Lee Jeong Heon , Kossenkov Andrew V. , Wu Sherry Y. , Wickramasinghe Jayamanna M. , Yin Xiangfan , Palozola Katherine C. , Gardini Alessandro , Showe Louise C. , Zaret Kenneth S. , Liu Qin , Speicher David , Conejo-Garcia Jose R. , Bradner James E. , Zhang Zhiguo , Sood Anil K. , Ordog Tamas , Bitler Benjamin G. , Zhang Rugang
Published: April 2023

ALDH activity and ALDH1A1 expression are regulated by BRD4 in a c-MYC-independent manner.
Supplementary Material and Methods from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells
Authors: Kaur Amanpreet , Denisova Oxana V. , Qiao Xi , Jumppanen Mikael , Peuhu Emilia , Ahmed Shafiq U. , Raheem Olayinka , Haapasalo Hannu , Eriksson John , Chalmers Anthony J. , Laakkonen Pirjo , Westermarck Jukka
Published: April 2023

Supplementary Material and Methods
Supplemental Materials and Methods from A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant
Authors: Ronald John A. , Kim Byung-Su , Gowrishankar Gayatri , Namavari Mohammad , Alam Israt S. , D'Souza Aloma , Nishikii Hidekazu , Chuang Hui-Yen , Ilovich Ohad , Lin Chih-Feng , Reeves Robert , Shuhendler Adam , Hoehne Aileen , Chan Carmel T. , Baker Jeanette , Yaghoubi Shahriar S. , VanBrocklin Henry F. , Hawkins Randall , Franc Benjamin L. , Jivan Salma , Slater James B. , Verdin Emily F. , Gao Kenneth T. , Benjamin Jonathan , Negrin Robert , Gambhir Sanjiv Sam
Published: April 2023

CHO Cell Transfection Tracer Uptake and Efflux Assays for Adherent Cells Western Blot Immunofluorescence Staining of Lymphoid Organs Ex Vivo Donor T Cell Proliferation Analysis Automated preparation of [18F]FAraG for human imaging using the Neptis perform PET synthesizer Imaging Studies in Humans Statistics
Supplementary Information from The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity
Authors: Holbeck Susan L. , Camalier Richard , Crowell James A. , Govindharajulu Jeevan Prasaad , Hollingshead Melinda , Anderson Lawrence W. , Polley Eric , Rubinstein Larry , Srivastava Apurva , Wilsker Deborah , Collins Jerry M. , Doroshow James H.
Published: April 2023

This file contains: Supplementary Methods for pharmacodynamic biomarker analyses, clinicaltrials.gov searches, and molecular correlation analyses; Supplementary Figures S1 (overview of the NCI-ALMANAC web resource), S2 (apoptotic biomarker response to bortezomib-clofarabine), and S3 (associations between ABC transporter activity and nilotinib-paclitaxel combination activity); and Supplementary Tables S1 (FDA-approved agents used in the NCI-ALMANAC screen), S2 (tumor doubling time analysis of xenograft experiments with clinically tested NCI-ALMANAC-derived combinations), S3 (in vitro, in vivo, and clinical activity of NCI-ALMANAC-derived combinations), and S4 (tumor doubling time analysis of xenograft experiments with novel NCI-ALMANAC-derived combinations).