bluuebunny/crossref_metadata_2025 huggingface dataset:
Emergency Logistics Facilities Location Dual-Objective Modeling in Uncertain Environments
Authors: Xu Fang , Ma Yifan , Liu Chang , Ji Ying
Published: February 2024

The uncertainty of post-earthquake disaster situations can affect the efficiency of rescue site selection, material, and personnel dispatching, as well as the sustainability of related resources. It is crucial for decision-makers to make decisions to mitigate risks. This paper first presents a dual-objective model for locating emergency logistics facilities, taking into account location costs, human resource scheduling costs, transportation time, and uncertainties in demand and road conditions. Then, stochastic programming and robust optimization methods are utilized to cater to decision-makers with varying risk preferences. A risk-preference-based stochastic programming model is introduced to handle the potential risks of extreme disasters. Additionally, robust models are constructed for two uncertain environments. Finally, the study uses the Wenchuan earthquake as a case study for the pre-locating of emergency logistics facilities and innovatively compares the differences in the effects of models constructed using different uncertainty methods. Experimental results indicate that changes in weight coefficients and unit transportation costs significantly impact the objective function. This paper suggests that decision-makers should balance cost and rescue efficiency by choosing appropriate weight coefficients according to the rescue stage. It also shows that risk level and robust conservatism can significantly alter the objective function. While stochastic programming models offer economic advantages, robust optimization provides better robustness.
An Analytic Hierarchy Process Method to Evaluate Environmental Impacts of In Situ Oil Shale Mining
Authors: Wang Xiaorong , Liu Boyue , He Shaolin , Yuan Hongying , Ji Dongli , Qi Li , Song Yang , Xu Wei
Published: February 2024

The great demand for oil shale resource development and the corresponding threats to the environment have resulted in the urgent need to assess the impact of oil shale in situ mining on the environment. In this paper, based on an analysis method developed by the previous literature and the Delphi technique, three secondary indicators and ten tertiary indicators were selected. The weights of the indicators at all levels were subsequently calculated. The results identify environmental capacity, groundwater risk and prevention, and cleaner production as having the largest weights in the indicator system. Following this, the typical three-level indicators with the largest weight and content related to carbon emissions were introduced in detail, and combined with the calculated weight of each indicator, the comprehensive evaluation index method was used to determine the comprehensive evaluation model for the environmental impact of oil shale in situ mining. The comprehensive evaluation model value, PA, of the target layer (the primary indicator) under two different heating methods, combustion heating and electric heating, were then calculated based on the oil shale in situ mining area in Fuyu City, Jilin Province, China. This study introduces carbon-emission-related elements into the three-level indicator evaluation calculation model, which is a more accurate and advanced comprehensive evaluation method.
The Emission Characteristics of Greenhouse Gases from Animal Husbandry in Shandong Province Based on Life Cycle Assessment
Authors: Li Zemin , Wei Qihang , Liu Xiayan , Zhu Rongsheng , Li Cuilan , Li Zhaojun
Published: February 2024

Life cycle assessment was used to study the following six major stages of animal husbandry: feed grain planting, feed grain transportation and processing, livestock and poultry breeding, livestock and poultry gastrointestinal fermentation, manure management, and livestock and poultry product slaughter and processing. The greenhouse gas emissions from animal husbandry in Shandong Province were quantified for the entire 20-year period spanning from 2002 to 2021. This study also analyzed the emission patterns and characteristics associated with this life cycle assessment. The results show that over the past 20 years, the greenhouse gas emissions from animal husbandry in Shandong Province increased continuously, the greenhouse gas emission intensity decreased continuously, and both of these trends tended to be stable. From a life cycle standpoint, the primary sources of greenhouse gas emissions were gastrointestinal fermentation and the management of livestock and poultry manure. In terms of the structure of livestock and poultry breeding, poultry was the primary source of greenhouse gas emissions. The emission characteristics of the greenhouse gases produced by animal husbandry varied among different cities in Shandong Province. The main source of greenhouse gas discharged due to animal husbandry in Zibo and Binzhou was Ecattle; in Dongying, it was Esheep; and in the remaining cities, it was mainly Epoultry.
Sustainable Emotional Design Based on Industry 4.0 for Industrial Nougat Packaging
Authors: Casales-Garcia Vicente , de las Heras Ana , Luque Amalia , Gonzalez-Abril Luis
Published: February 2024

Nowadays, digitalisation is present in all links of the product life cycle and within product design. Packaging is a critical element that affects the customer’s purchase intention. Therefore, packaging is one of the elements for which it is positive to include techniques and methods based on Industry 4.0 to obtain results from users and bring them closer to the process. The relationship between packaging and the expected quality and emotions of users is a topic that is addressed in the social axis of sustainability and involves an effort to strengthen the relationship with the user. This article studies the expected quality of nougat in terms of packaging shape and colour using ANOVA analysis. For this purpose, a survey was carried out among 122 participants in Spain and Mexico. The main conclusion is that packaging with a combination of three shapes (rectangle, square and triangle) and colours (yellow, orange and red) enhances consumers’ emotions of Admiration, Satisfaction, Pleasant Surprise, Attraction, Fascination and Joy.
A New Resource Allocation Multiple Criteria Decision-Making Method in a Two-Stage Inverse Data Envelopment Analysis Framework for the Sustainable Development of Chinese Commercial Banks
Authors: Liao Li-Huan , Chen Lei , Wang Junchao
Published: February 2024

The resource allocation of commercial banks is a multiple-criteria decision-making issue with complex internal structure, and traditional inverse data envelopment analysis cannot meet its decision-making needs. A two-stage structure with undesirable outputs is constructed to describe the operations of a Chinese commercial bank, and then a new two-stage inverse data envelopment analysis with undesirable outputs is proposed to address its resource allocation multiple criteria decision-making issue. The new method can be used to calculate the minimum input increment required to achieve the goals of desirable and undesirable output under a certain efficiency, and then a specific resource allocation plan can be obtained to promote the sustainable development of commercial banks. Finally, the new method is applied to the resource allocation of 16 Chinese listed commercial banks in 2013, and the application results fully demonstrate the effectiveness of the new method.
Spatio-Temporal Heterogeneity of the Ecological Environment and Its Response to Land Use Change in the Chushandian Reservoir Basin
Authors: Fang Yichen , Cao Lianhai , Guo Xinyu , Liang Tong , Wang Jiyin , Wang Ning , Chao Yue
Published: February 2024

Conducting ecological monitoring assessments and revealing the effects of driving factors are crucial for enhancing ecological safety and promoting sustainable development. Taking the Chushandian Reservoir basin as the research object, this paper employed the Remote Sensing Ecological Index (RSEI), constructed based on remote sensing data, to monitor and assess the ecological environment of the study area from 1990 to 2021, and predicted its future development trend through the Hurst index. On this basis, we integrated land use data to elucidate the response of the ecological environment to human activities. The results show that: (1) The mutation test indicates that selecting 1990, 2004, 2008, 2013, and 2021 as the study time nodes can comprehensively reflect the spatio-temporal information regarding changes in ecological quality in the study area. Specifically, both 1990 and 2021 exhibit higher ecological quality ratings, while 2008 has the lowest ecological quality rating. The spatial distribution of ecological quality is strongly clustered, with high–high clustering and low–low clustering dominating. (2) The overall trend of ecological quality in the study area appears in a pattern of initial decline followed by subsequent improvement. From 1990 to 2004, the degraded area constituted the largest proportion, accounting for 87.82%. After 2008, the quality of the ecological environment began to rebound. Between 2008 and 2013, the proportion of regions with improved ecological conditions was 57.91%, and from 2013 to 2021, 46.74% of the regions showed improvement. (3) In the research area, 36.70% of the regions exhibit a trend of sustainable stability into the future, representing the highest proportion. Approximately 34.3% of the areas demonstrate a trend of sustainable improvement, while the regions exhibiting sustainable degradation account for only 5.72%. While the ecological environment is demonstrating a positive overall developmental trend, it is crucial to stay vigilant regarding areas of ongoing degradation and implement appropriate protective measures. (4) Land use change significantly impacts the ecological environment, with the expansion of land for urban build up causing some ecological deterioration, while the later expansion of forest improves ecological quality. The results provide theoretical approaches and a foundation for decision-making in the ecological management of the Chushandian Reservoir basin.
Why Do Hungarian Health Workers Migrate? A Micro-Level Analysis
Authors: Pál Viktor , Fabula Szabolcs , Boros Lajos
Published: February 2024

The sustainability of healthcare systems is challenged by the international migration of health workers in many countries. Like other Central and Eastern European (CEE) countries, a great number of health professionals from Hungary have emigrated recently, increasing the shortage of health workers in the country. The aim of this study is to explore the migration attitudes of Hungarian health workers, applying a micro-level approach of push–pull factors. For this purpose, semi-structured interviews have been conducted with practicing and inactive Hungarian health professionals living in Hungary and abroad. The interviews were subjected to a thematic analysis, and the following groups of factors were revealed and discussed: wealth and income, workplace, human capital, quality of life, family, personal network, and personality. In addition, geography and life stage (life course) as two overarching, integrative categories are also discussed. The results point to the role of income, work environment, and family in migration decisions. As a new factor, the importance of geographical characteristics (local context, distance) is also explored, which has received less attention in previous studies. A novelty of our study is the CEE post-socialist point of view, mirrored by the life-path elements of the interviews. Another novelty is the qualitative and micro-level approach, forming the basis of policy recommendations presented at the end of our study.
The Identification of Influential Nodes Based on Neighborhood Information in Asymmetric Networks
Authors: Liu Gehui , Chen Yuqi , Chen Haichen , Dai Jiehao , Wang Wenjie , Yu Senbin
Published: February 2024

Identifying influential nodes, with pivotal roles in practical domains like epidemic management, social information dissemination optimization, and transportation network security enhancement, is a critical research focus in complex network analysis. Researchers have long strived for rapid and precise identification approaches for these influential nodes that are significantly shaping network structures and functions. The recently developed SPON (sum of proportion of neighbors) method integrates information from the three-hop neighborhood of each node, proving more efficient and accurate in identifying influential nodes than traditional methods. However, SPON overlooks the heterogeneity of neighbor information, derived from the asymmetry properties of natural networks, leading to its lower accuracy in identifying essential nodes. To sustain the efficiency of the SPON method pertaining to the local method, as opposed to global approaches, we propose an improved local approach, called the SSPN (sum of the structural proportion of neighbors), adapted from the SPON method. The SSPN method classifies neighbors based on the h-index values of nodes, emphasizing the diversity of asymmetric neighbor structure information by considering the local clustering coefficient and addressing the accuracy limitations of the SPON method. To test the performance of the SSPN, we conducted simulation experiments on six real networks using the Susceptible–Infected–Removed (SIR) model. Our method demonstrates superior monotonicity, ranking accuracy, and robustness compared to seven benchmarks. These findings are valuable for developing effective methods to discover and safeguard influential nodes within complex networked systems.
Bee Venom Stimulates Growth Factor Release from Adipose-Derived Stem Cells to Promote Hair Growth
Authors: Kim Jung Hyun , Kim Tae Yoon , Goo Bonhyuk , Park Yeoncheol
Published: February 2024

Limited evidence suggests that stimulating adipose-derived stem cells (ASCs) indirectly promotes hair growth. We examined whether bee venom (BV) activated ASCs and whether BV-induced hair growth was facilitated by enhanced growth factor release by ASCs. The induction of the telogen-to-anagen phase was studied in mice. The underlying mechanism was investigated using organ cultures of mouse vibrissa hair follicles. When BV-treated ASCs were injected subcutaneously into mice, the telogen-to-anagen transition was accelerated and, by day 14, the hair weight increased. Quantitative polymerase chain reaction (qPCR) revealed that BV influenced the expression of several molecules, including growth factors, chemokines, channels, transcription factors, and enzymes. Western blot analysis was employed to verify the protein expression levels of extracellular-signal-regulated kinase (ERK) and phospho-ERK. Both the Boyden chamber experiment and scratch assay confirmed the upregulation of cell migration by BV. Additionally, ASCs secreted higher levels of growth factors after exposure to BV. Following BV therapy, the gene expression levels of alkaline phosphatase (ALP), fibroblast growth factor (FGF)-1 and 6, endothelial cell growth factor, and platelet-derived growth factor (PDGF)-C were upregulated. The findings of this study suggest that bee venom can potentially be utilized as an ASC-preconditioning agent for hair regeneration.
N-Terminal α-Helices in Domain I of Bacillus thuringiensis Vip3Aa Play Crucial Roles in Disruption of Liposomal Membrane
Authors: Shao Ensi , Huang Hanye , Yuan Jin , Yan Yaqi , Ou Luru , Chen Xiankun , Pan Xiaohong , Guan Xiong , Sha Li
Published: February 2024

Bacillus thuringiensis Vip3 toxins form a tetrameric structure crucial for their insecticidal activity. Each Vip3Aa monomer comprises five domains. Interaction of the first four α-helices in domain I with the target cellular membrane was proposed to be a key step before pore formation. In this study, four N-terminal α-helix-deleted truncations of Vip3Aa were produced and, it was found that they lost both liposome permeability and insecticidal activity against Spodoptera litura. To further probe the role of domain I in membrane permeation, the full-length domain I and the fragments of N-terminal α-helix-truncated domain I were fused to green fluorescent protein (GFP), respectively. Only the fusion carrying the full-length domain I exhibited permeability against artificial liposomes. In addition, seven Vip3Aa-Cry1Ac fusions were also constructed by combination of α-helices from Vip3Aa domains I and II with the domains II and III of Cry1Ac. Five of the seven combinations were determined to show membrane permeability in artificial liposomes. However, none of the Vip3Aa-Cry1Ac combinations exhibited insecticidal activity due to the significant reduction in proteolytic stability. These results indicated that the N-terminal helix α1 in the Vip3Aa domain I is essential for both insecticidal activity and liposome permeability and that domain I of Vip3Aa preserved a high liposome permeability independently from domains II–V.
Trichothecenes and Fumonisins: Key Players in Fusarium–Cereal Ecosystem Interactions
Authors: Perochon Alexandre , Doohan Fiona M.
Published: February 2024

Fusarium fungi produce a diverse array of mycotoxic metabolites during the pathogenesis of cereals. Some, such as the trichothecenes and fumonisins, are phytotoxic, acting as non-proteinaceous effectors that facilitate disease development in cereals. Over the last few decades, we have gained some depth of understanding as to how trichothecenes and fumonisins interact with plant cells and how plants deploy mycotoxin detoxification and resistance strategies to defend themselves against the producer fungi. The cereal-mycotoxin interaction is part of a co-evolutionary dance between Fusarium and cereals, as evidenced by a trichothecene-responsive, taxonomically restricted, cereal gene competing with a fungal effector protein and enhancing tolerance to the trichothecene and resistance to DON-producing F. graminearum. But the binary fungal–plant interaction is part of a bigger ecosystem wherein other microbes and insects have been shown to interact with fungal mycotoxins, directly or indirectly through host plants. We are only beginning to unravel the extent to which trichothecenes, fumonisins and other mycotoxins play a role in fungal-ecosystem interactions. We now have tools to determine how, when and where mycotoxins impact and are impacted by the microbiome and microfauna. As more mycotoxins are described, research into their individual and synergistic toxicity and their interactions with the crop ecosystem will give insights into how we can holistically breed for and cultivate healthy crops.
Probing for Lorentz Invariance Violation in Pantheon Plus Dominated Cosmology
Authors: Staicova Denitsa
Published: February 2024

The Hubble tension in cosmology is not showing signs of alleviation and thus, it is important to look for alternative approaches to it. One such example would be the eventual detection of a time delay between simultaneously emitted high-energy and low-energy photons in gamma-ray bursts (GRB). This would signal a possible Lorentz Invariance Violation (LIV) and in the case of non-zero quantum gravity time delay, it can be used to study cosmology as well. In this work, we use various astrophysical datasets (BAO, Pantheon Plus and the CMB distance priors), combined with two GRB time delay datasets with their respective models for the intrinsic time delay. Since the intrinsic time delay is considered the largest source of uncertainty in such studies, finding a better model is important. Our results yield as quantum gravity energy bound EQG≥1017 GeV and EQG≥1018 GeV respectively. The difference between standard approximation (constant intrinsic lag) and the extended (non-constant) approximations is minimal in most cases we conside. However, the biggest effect on the results comes from the prior on the parameter cH0rd, emphasizing once again that at current precision, cosmological datasets are the dominant factor in determining the cosmology. We estimate the energies at which cosmology gets significantly affected by the time delay dataset.
Nonrelativistic Quantum Mechanical Problem for the Cornell Potential in Lobachevsky Space
Authors: Jenkovszky Laszlo , Kurochkin Yurii Andreevich , Shaikovskaya N. D. , Soloviev Vladimir Olegovich
Published: February 2024

In Friedmann–Lobachevsky space-time with a radius of curvature slowly varying over time, we study numerically the problem of motion of a particle moving in the Cornell potential. The mass of the particle is taken to be a reduced mass of the charmonium system. In contrast to the similar problem in flat space, in Lobachevsky space the Cornell potential has a finite depth and, as a consequence, the number of bound states of the system is finite and motion with a continuum energy spectrum is also possible. In this paper, we study the bound states as well as the scattering states of the system.
Quantum Scalar Fields Interacting with Quantum Black Hole Asymptotic Regions
Authors: Gambini Rodolfo , Pullin Jorge
Published: February 2024

We continue our work on the study of spherically symmetric loop quantum gravity coupled to two spherically symmetric scalar fields, with one that acts as a clock. As a consequence of the presence of the latter, we can define a true Hamiltonian for the theory. In previous papers, we studied the theory for large values of the radial coordinate, i.e., far away from any black hole or star that may be present. This makes the calculations considerably more tractable. We have shown that in the asymptotic region, the theory admits a large family of quantum vacua for quantum matter fields coupled to quantum gravity, as is expected from the well-known results of quantum field theory on classical curved space-time. Here, we study perturbative corrections involving terms that we neglected in our previous work. Using the time-dependent perturbation theory, we show that the states that represent different possible vacua are essentially stable. This ensures that one recovers from a totally quantized gravitational theory coupled to matter the standard behavior of a matter quantum field theory plus low probability transitions due to gravity between particles that differ at most by a small amount of energy.
The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response
Authors: van Huizen Mariska , Vendrell Xavier M. , de Gruyter Heidi L. M. , Boomaars-van der Zanden A. Linda , van der Meer Yvonne , Snijder Eric J. , Kikkert Marjolein , Myeni Sebenzile K.
Published: February 2024

Mitochondrial antiviral signaling protein (MAVS) is a crucial signaling adaptor in the sensing of positive-sense RNA viruses and the subsequent induction of the innate immune response. Coronaviruses have evolved multiple mechanisms to evade this response, amongst others, through their main protease (Mpro), which is responsible for the proteolytic cleavage of the largest part of the viral replicase polyproteins pp1a and pp1ab. Additionally, it can cleave cellular substrates, such as innate immune signaling factors, to dampen the immune response. Here, we show that MAVS is cleaved in cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV), but not in cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This cleavage was independent of cellular negative feedback mechanisms that regulate MAVS activation. Furthermore, MERS-CoV Mpro expression induced MAVS cleavage upon overexpression and suppressed the activation of the interferon-β (IFN-β) and nuclear factor-κB (NF-κB) response. We conclude that we have uncovered a novel mechanism by which MERS-CoV downregulates the innate immune response, which is not observed among other highly pathogenic coronaviruses.
DOLAMA 200: Effectiveness and Safety of a Dual Therapy with Dolutegravir Plus Lamivudine in Treatment-Experienced HIV-1 Infected Real World Participants in Spain
Authors: Sequera-Arquelladas Sergio , Hidalgo-Tenorio Carmen , López-Cortés Luis , Gutiérrez Alicia , Santos Jesús , Téllez Francisco , Omar Mohamed , Ferra-Murcia Sergio , Fernández Elisa , Javier Rosario , García-Vallecillos Coral , Pasquau Juan
Published: February 2024

The continuous pharmacological advances in antiretroviral treatment (ART) and the increasing understanding of HIV drug resistance has led to a change in the paradigm of ART optimization in the setting of the viral suppression of treatment-experienced patients with the emerging evidence of the effectiveness and safety of dual therapies. The aim of this study is to determine the antiviral efficacy and safety of switching to Dolutegravir + Lamivudine in people living with HIV, and to analyze the rate of patients with virologic failure (VF). A total of 200 patients were included with a median age of 51 years, 189 cells/µL of nadir CD4+, 13 years on ART and four previous ART regimens. Among the 168 patients who completed a follow-up at 48 weeks, a total of five VFs occurred, resulting in a 2.98% (5/168) VF rate. The results of the intention-to-treat analysis were a VF rate of 2.54% (5/197), and the rate of patients/year with viral suppression was 98.3% (298/303) in the observed data analysis. We observed a significant improvement in mean CD4 lymphocytes, the CD4/CD8 ratio and lipid profiles. The optimization of ART to DTG plus 3TC is a cost-effective switch option for treatment-experienced HIV patients, and also improves their lipid profiles.
Impact of Tuberculosis on Disease Severity and Viral Shedding Duration in COVID-19 Patients
Authors: Huang Wei , Liu Ping , Yan Bo , Zheng Fang , Yang Yang , Xi Xiuhong , Xia Lu , Shen Yinzhong
Published: February 2024

Accumulating evidence show a potential association between tuberculosis and COVID-19 disease severity. To further clarify the impact of tuberculosis on COVID-19 disease severity and viral shedding duration, a retrospective study was conducted on 223 COVID-19 patients, including 34 with tuberculosis and 189 without tuberculosis. Clinical information and viral load shedding time were collected. A higher percentage of severe/critical COVID-19 diagnosis and deaths was observed in patients with tuberculosis than in those without tuberculosis (8.8% vs. 3.2%, p = 0.142; 2.9% vs. 1.1%, p = 0.393), and COVID-19 patients with tuberculosis had longer viral shedding than those without tuberculosis (median: 15.0 days vs. 11.0 days; p = 0.0001). Having tuberculosis (HR = 2.21, 95% CI 1.37–3.00; p = 0.000), being of elderly age (HR = 1.02, 95% CI 1.01–1.03; p = 0.001) and being diagnosed with severe or critical COVID-19 (HR = 5.63, 95% CI 2.10–15.05; p = 0.001) were independent factors associated with prolonged virus time of SARS-CoV-2. COVID-19 patients with tuberculosis receiving anti-tuberculosis therapy time (ATT) for <2 months had a significantly longer virus shedding duration than those receiving ATT for ≥ 4 months (17.5 vs. 11.5 days, p = 0.012). Our results demonstrated that COVID-19 patients with tuberculosis tend to have more severe disease and a worse prognosis, and tuberculosis prolonged viral shedding, highlighting special attention and/or care required for COVID-19 patients with tuberculosis receiving ATT for <2 months.
CircRNA-5335 Regulates the Differentiation and Proliferation of Sheep Preadipocyte via the miR-125a-3p/STAT3 Pathway
Authors: Guo Wei , Ciwang Renzeng , Wang Lei , Zhang Shuer , Liu Nan , Zhao Jinshan , Zhou Lisheng , Li Hegang , Gao Xiaoxiao , He Jianning
Published: February 2024

The content of intramuscular fat (IMF) from preadipocytes is proportional to meat quality in livestock. However, the roles of circRNAs in IMF deposition in sheep are not well known. In this study, we show that circRNA-5335/miR-125a-3p/STAT3 play a crucial adjective role in the proliferation and differentiation of sheep preadipocytes. In this study, we characterized the roles of differentially expressed circRNA-5335/miR-125a-3p/STAT3, which were screened from sheep of different months of age and based on sequencing data. Firstly, the expression profiles of circRNA-5335/miR-125a-3p/STAT3 were identified during the differentiation of preadipocytes in vitro by RT-qPCR and WB. Then, the targeting relationship of the circRNA-5335/miR-125a-3p/STAT3 was verified by dual-luciferase reporter assays. The results of RT-qPCR, CCK8, EdU and Oil Red O staining assay showed that miR-125a-3p suppressed the differentiation and raised the proliferation of preadipocytes by targeting STAT3. As a competing endogenous RNA, the downregulation of circRNA-5335 decreased the expression of STAT3 by increasing miR-125a-3p, which inhibited the differentiation of preadipocytes and promoted proliferation. Our present study demonstrates the functional significance of circRNA-5335/miR-125a-3p/STAT3 in the differentiation of sheep preadipocytes, and provides novel insights into exploring the mechanism of IMF.
Cutaneous Plasmacytoma with Systemic Metastases in a Cape Serotine Bat (Laephotis capensis)
Authors: van der Weyden Louise , Avenant Alida , O’Dell Nicolize
Published: February 2024

Despite their relatively long life-spans, reports of neoplasia in bats are rare and are limited to a handful of cases. In this report, we describe a 2-year-old female wild Cape serotine bat (Laephotis capensis) that had been caught by a domestic cat and presented with a skin mass over the chest area. Histopathological analysis of a subsequent biopsy revealed proliferating sheets of neoplastic round cells, occasionally appearing to form packets, supported by a fine, fibrovascular stroma. Marked nuclear pleomorphism was seen, as well as a high mitotic count. Immunohistochemistry displayed positive labelling for MUM1 in the neoplastic cells. The diagnosis was extramedullary plasmacytoma (EMP); a neoplasm consisting of plasma cells derived from B lymphocytes. Due to a deteriorating condition, the bat was anaesthetised, and the mass was surgically removed two weeks later. However, the bat succumbed under the anaesthetic. Histopathological examination of the mass showed the same neoplastic cell population as observed in the biopsy; in addition, there was a locally extensive infiltration of neoplastic cells in the spleen and a mild presence of neoplastic cells in circulation. This is the first report of an EMP in a bat, and we compare the findings with that seen in dogs and cats.
Identify Candidate Genes Associated with the Weight and Egg Quality Traits in Wenshui Green Shell-Laying Chickens by the Copy Number Variation-Based Genome-Wide Association Study
Authors: Yang Suozhou , Ning Chao , Yang Cheng , Li Wenqiang , Zhang Qin , Wang Dan , Tang Hui
Published: February 2024

Copy number variation (CNV), as an essential source of genetic variation, can have an impact on gene expression, genetic diversity, disease susceptibility, and species evolution in animals. To better understand the weight and egg quality traits of chickens, this paper aimed to detect CNVs in Wenshui green shell-laying chickens and conduct a copy number variation regions (CNVRs)-based genome-wide association study (GWAS) to identify variants and candidate genes associated with their weight and egg quality traits to support related breeding efforts. In our paper, we identified 11,035 CNVRs in Wenshui green shell-laying chickens, which collectively spanned a length of 13.1 Mb, representing approximately 1.4% of its autosomal genome. Out of these CNVRs, there were 10,446 loss types, 491 gain types, and 98 mixed types. Notably, two CNVRs showed significant correlations with egg quality, while four CNVRs exhibited significant associations with body weight. These significant CNVRs are located on chromosome 4. Further analysis identified potential candidate genes that influence weight and egg quality traits, including FAM184B, MED28, LAP3, ATOH8, ST3GAL5, LDB2, and SORCS2. In this paper, the CNV map of the Wenshui green shell-laying chicken genome was constructed for the first time through population genotyping. Additionally, CNVRs can be employed as molecular markers to genetically improve chickens’ weight and egg quality traits.
Reconstructing Historical Intense and Total Summer Rainfall in Central North Carolina Using Tree-Ring Data (1770–2020)
Authors: Mitchell Tyler J. , Knapp Paul A.
Published: February 2024

Contextualizing historic hydroclimate variability in the southeastern USA has relied significantly on proxy indicators such as tree-ring data, and while previous studies have reconstructed total precipitation, less is known about the historic variability of intense rainfall events, which are climatologically and ecologically important and distinct from non-intense rainfall events. Here, a combined longleaf pine and shortleaf pine adjusted latewood chronology spanning 1770–2020 was used to reconstruct July–September total precipitation and intense rainfall event precipitation in central North Carolina, USA. The adjusted latewood chronology explains 46% of the variance in July–September total precipitation and 37% of the variance in July–September intense rainfall event precipitation during the 1940–2020 instrumental period with intense rainfall event precipitation amounts comprising 52% of total precipitation amounts. The models provide context about historic hydroclimate variability at this location and suggest overall stability in both total and intense rainfall event precipitation amounts during the instrumental and reconstruction periods with three identical significant regime shifts during 1770–2020: 1770–1935, 1936–1959 (above-average moisture), 1960–2020 (below-average moisture). To compare model strength, the models were split into early (1940–1980) and late (1981–2020) analysis periods with the intense rainfall event precipitation model exhibiting greater skill during the early analysis period. The early analysis period has a greater frequency and magnitude of intense rainfall events, and these results suggest the influence of intense rainfall event precipitation on latewood growth and the potential susceptibility of reconstruction models to decreased skill and/or error with differing frequencies of extreme events, a finding of particular importance to future dendroclimatic research.
History of Human Papilloma Virus Vaccination with a Focus on Italy
Authors: Gabutti Giovanni , Ogliastro Matilde
Published: February 2024

The Italian National Immunization Plan (NIP) states that public health today aims at immunizing adolescents of both sexes for maximum protection against all HPV-related vaccine-preventable diseases. Nowadays, the vaccination offer to primary cohorts is reaffirmed with continued free vaccination up to at least 26 years of age for females and up to at least 18 years of age for males. The Italian NIP 2023–2025 recommends HPV vaccination for at-risk categories, including individuals with HIV, men who have sex with men (MSM), women treated for intermediate- or high-grade lesions, and travelers. Catch-up vaccination is recommended for women at least up to 26 years of age, also using the appropriate occasion of the call for the first screening for the prevention of cervical cancer as an opportunity for vaccination, and for men at least up to and including 18 years of age if they have not been previously vaccinated or have not completed the vaccination cycle. In summary, the Italian vaccination offer has been extended to additional cohorts in order to reduce the burden of HPV-related diseases and to improve vaccination coverage of the Italian population.
Employment contract with a minor employee
Authors:   Department of Business and Financial Law Baikal State University, Irkutsk, Filchakova Sv. Yu.
Published: February 2024

The article discusses current problematic aspects related to concluding an employment contract with minors. As a result of the study, the conclusion is substantiated about the need to improve the labor legislation of the Russian Federation in order to fully implement the right to work and effectively protect workers under 18 years of age.
Categories of personal data of employees
Authors:   Department of Land, Labor and Environmental Law Federal State Budgetary Educational Institution of Higher Education ", Novikova Yu.Al. ,   Kuban State Agrarian University named after I.T. Trubilin",   , Krasnodar, Russia
Published: February 2024

The legislation on personal data has changed significantly in recent years, data processing requirements have been tightened. The trend will obviously continue, taking into account the development of technologies, the development and implementation of artificial intelligence, which will require appropriate legal regulation and strengthening the protection of personal data of certain categories. This article is devoted to highlighting and studying various categories of personal data of employees, as well as special rules for their processing.
Electrogeneration of Hypochlorite Ions using a Dimensionally Stable Anode-Type (Ti/PtPd(10%)Ox) Electrode
Authors: Zayas Teresa , Vega Miriam , Soriano-Moro Guillermo , Handal Anabella , Morales Miguel , Salgado Leonardo
Published: February 2024

The study examined the electrogeneration of hypochlorite ions (ClO−) via electrolysis of aqueous NaCl solutions using a dimensionally stable anode-type (DSA-type) electrode based on platinum and palladium oxides supported on titanium mesh (Ti/PtPd(10%)Ox). The electrogenerated ClO− was quantified on the basis of the absorption band at 292 nm (Aλ = 292) of the UV-Vis spectrum. The effect of initial pH, concentration of NaCl, cell potential difference and electrolysis time were investigated in this study. The results showed that the electrolysis of aqueous NaCl solutions increases the solution pH up to high values (≥ 8.0) that favor the formation of ClO− over chlorine or hypochlorous acid. The hypochlorite concentration increases significantly at pH values > 7.0 and shows a linear trend with increasing NaCl concentration and with increasing cell potential difference. When the cell potential and NaCl concentration are held constant, the maximum hypochlorite value during electrolysis depends on both the cell potential and NaCl concentration. The Ti/PtPd(10%)Ox anode favors the production of hypochlorite ions, making this anode a promising material for use in electrochemical oxidation of wastewater via an indirect mechanism.
Patient-Level and Center-Level Factors Associated with Required Predonation Weight Loss among Obese Living Kidney Donors
Authors: Perry Jackson , McLeod M. Chandler , Reed Rhiannon D. , Baker Gavin A. , Stanford Luke A. , Allen Joshua , Jones Bernarez , Robinson Tayana , MacLennan Paul A. , Kumar Vineeta , Locke Jayme E.
Published: February 2024

Key Points

Among obese living kidney donors, year of donation, preoperative body mass index, hypertension, and center percent of living kidney donor transplants were associated with required predonation weight loss.

There were no significant differences in the likelihood of predonation weight loss requirement by race, sex, or age or by markers of preoperative metabolic dysfunction.

Background

The proportion of overweight/mildly obese living kidney donors (OLKDs) has increased in the past few decades, with significant center variation in the body mass index (BMI) of LKDs. The purpose of this study was to examine factors associated with required predonation weight loss among OLKDs (BMI, ≥30 kg/m2).

Methods

This retrospective cohort study surveyed 1097 OLKDs (1979–2020) (mean BMI, 33 kg/m2) about their donation experience. Bivariate analyses compared donor demographic and center characteristics by whether the donor reported predonation weight loss requirement. Generalized estimating equations with logit link were used to estimate marginal effects of patient-level and center-level factors. Multiple imputation using chained equations was implemented to account for missing values.

Results

Of 1097 OLKDs surveyed, 340 (31.0%) reported predonation weight loss requirement. Donors with a predonation weight loss requirement had slightly higher predonation BMIs and donated in more recent years at centers performing a lower percentage of living donor nephrectomies and with a lower median BMI. In multivariable logistic regression analysis, we observed transplant year (odds ratio [OR], 1.04 per year donation; 95% confidence interval [CI], 1.01 to 1.07; P = 0.005), preoperative BMI (OR, 1.16; 95% CI, 1.05 to 1.28; P < 0.01), preoperative hypertension (OR, 1.61; 95% CI, 1.08 to 2.40; P = 0.02), and center percentage of living donor kidney transplants (OR, 0.99; 95% CI, 0.98 to 1.00; P = 0.02) as significantly associated with a predonation weight loss requirement. The study found no differences in the likelihood of predonation weight loss requirement by race, sex, age, preoperative creatinine, preoperative metabolic dysfunction, or center-level median BMI of living donors.

Conclusions

These results suggest that both center-level and patient-level factors influence whether OLKDs are required to lose weight before donation. Future study is needed to determine whether predonation weight loss is associated with improved long-term postdonation outcomes.
ЗДАТНІСТЬ ДО ВЕРБАЛІЗАЦІЇ ТІЛЕСНОГО Я У ОСІБ З РІЗНИМ РІВНЕМ КОГНІТИВНОГО ІНСАЙТУ
Authors: Хомуленко Тамара , Гресь Юрій
Published: February 2024

Актуальність дослідження. Вивчення когнітивного інсайту у межах психічної норми є недостатнім, крім того недостатньо вивченою виявляється проблема ролі когнітивного інсайту у роботі з психосоматичними порушеннями, зокрема у консультуванні клієнтів із соматичними скаргами.

Мета дослідження – визначити відповідність між рівнем когнітивного інсайту у процесі психологічного супроводу осіб із соматичними скаргами та рівнем їх здатності до вербалізації тілесного Я.

Результати. Визначено відповідність між рівнем когнітивного інсайту та здатністю до вербалізації тілесного Я у осіб із соматичними скаргами.

Висновки.Вивчення когнітивного інсайту у досліджуваних із соматичними скаргами у процесі впровадження з ними програми психологічного супроводу, що містить оздоровчі психотехнології показало певну відповідність між його рівнем та специфікою здатності до вербалізації тілесного Я. Так, виявлено позитивні кореляції із когнітивним інсайтом та, передусім, здатністю фіксувати та концентрувати увагу на внутрішніх відчуттях, яка проявляється у їх диференційованій вербалізації. Крім того, існують прямі зв’язки когнітивного інсайту із обізнаністю про тіло взагалі та про власне тіло як продукт пізнання і аналізу власного тілесного досвіду, а також здатністю вбачати у тілі причину і наслідок подій внутрішнього і зовнішнього простору людини.

Визначено, що достатній (середній та високий) рівні когнітивного інсайту передбачають найвищі показники психосоматичної компетентності (здатності до вербалізації тілесного Я) у осіб із соматичними скаргами, натомість при низькому рівні когнітивного інсайту ці показники варіюють від низьких до середніх значень
ТРЕНІНГ ЯК ЗАСІБ РОЗВИТКУ ПРОФЕСІЙНО ЗНАЧУЩИХ ОСОБИСТІСНИХ ЯКОСТЕЙ ПЕДАГОГІВ ІНКЛЮЗИВНИХ ГРУП
Authors: Околович Олена , Клопота Євгеній
Published: February 2024

Актуальність дослідження. Проблема розвитку професійно значущих особистісних якостей педагогів інклюзивних груп закладів дошкільної освіти (далі ЗДО) набуває своєї важливості, зокрема у зв’язку із емоціогенністю професійної діяльності, високим ступенем емоційного напруження, постійної міжособистісної взаємодії з учасниками освітнього процесу.

Мета дослідження. Теоретично проаналізувати сутність та переваги використання тренінгу як засобу розвитку професійно значущих особистісних якостей педагогів інклюзивних груп ЗДО та перевірити ефективність впровадженої тренінгової програми.

Методи дослідження. Нами було використано метод аналізу та синтезу психологічної, психолого-педагогічної літератури та проведено експериментальне дослідження.

Результати і висновки. Проведений нами аналіз надав можливості зробити висновки, що професійно значущі особистісні якості педагогів інклюзивних груп закладів дошкільної освіти, зокрема емоційний інтелект, емпатію, толерантність можна і необхідно розвивати у будь-якому віці. Враховуючи те, що інклюзивна освіта вимагає розвиненості спеціальних навичок, можемо відзначити, що тренінг є ефективним засобом у розвитку професійно значущих особистісних якостей педагогів. Саме цей засіб організованого інтенсивного психолого-педагогічного впливу сприяє регуляції емоційних станів, допомагає у вирішенні професійного самовизначення, отримання знань та навичок з подальшим використанням результатів у покращенні інклюзивного процесу ЗДО. Можемо стверджувати, що тренінг є універсальним інструментом в роботі з педагогами інклюзивних груп ЗДО щодо розв’язання завдань, пов’язаних з вихованням, навчанням, розвитком дітей з ООП, умінням контролювати власні емоції, пізнання та сприйняття свого внутрішнього світу та дитини, а також особистісного, професійного зростання та зміцнення емоційного стану особистості.
Analysis and Development of a Football Scouting App based on Flutter: A Case Study of A3N
Authors: Zefrinaldi Andri , Selviandro Nungki , Wulandari Gia Septiana
Published: February 2024

Scouting is a crucial aspect of football, where the team's success depends heavily on the ability to select the right player. To minimize risk and optimize resources, teams can utilize the football scouting application. Unfortunately, existing applications still have limitations, especially in support of multiple platforms, and are open source. Therefore, this research is focused on developing a football scouting application that supports multiple platforms and is open source, using a single codebase-based Flutter Framework. Using Flutter, the app can be created based on just one code base, which can be compiled directly on Android and iOS platforms. The developed application has several superior features. First, the application allows the admin to insert player data into the database. Another feature is the ability to search for players based on names that users include. In addition, the application is also able to display a list of players based on the position chosen by the user. Finally, the application can display the complete data and statistics of the currently active player. Through the implementation of the selected development method, the implementation of this system can contribute significantly to supporting the scouting process in football teams. Thus, this application can increase the efficiency and effectiveness of decision-making within the scope of football scouting activities.
Gender-specific aspects of oncological diseases: focus on stomach cancer and colorectal cancer
Authors: Gataullin Ilgiz G. , Dinov Rishat M. , Gataullin Bulat I. , Erpert Yana А.
Published: February 2024

With each passing day, medicine strives to become more personalized, centered directly on the patient. A significant aspect of this dynamic involves the consideration of patients' gender, which influences their physiology, the pathogenesis of developing diseases, and their response to treatment.
Historically, most research has been conducted on male cells, male mice, and men, with women of childbearing age often excluded from studies for their safety. It was assumed that female cells were identical to male cells, leading medical research to be predominantly focused on male physiology. However, this approach was fundamentally flawed, as individuals of different sexes differ in terms of epidemiology, pathogenesis, clinical manifestations, disease progression, and responses to treatment. Knowledge of these gender-specific characteristics can aid clinicians in their patient management.
This literature review aims to examine the peculiarities of cancer progression in men and women, specifically in the cases of stomach and colorectal cancer.