bluuebunny/crossref_metadata_2025 huggingface dataset:
The catechism of normativity: Syncretic reflections on the philosophical foundations of military law
Authors: Kholikov Ivan V. , Dakhin Andrey V. , Kumankov Arseniy D. , Naumov Petr Yu. , Novikov Nikolay S.
Published: September 2024

Socio-political and international legal trends, the growing scale of military conflicts in various regions of the planet determine the attention of scientists and practitioners to the social nature and essence of military law and its institutions. The recent appearance of the monograph “Military Law” in three volumes (the third volume in two books) serves as proof of this attention in our country. This monograph reflects the key theoretical and legal constructs that form the foundation, the “core” of Military Law as a branch of law. It examines the genesis of Military Law, reveals the systemic prerequisites of Military Law, describes Russia’s military activity as an object of Military Law, substantiates the military organization of the state as a subject of Military Law, identifies the social value of Military Law, proves the place of Military Law in the system of legal norms as a branch of law, verifies system of Military Law, the main provisions of the Military Law of foreign countries are systematized, international legal aspects and the current state of Military Law are revealed. In the article, the authors reflect on the continuation of the ideas of the monograph “Military Law”, to search and substantiate the philosophical origins and grounds of its origin. The authors would like to draw your attention to the fact that today Military Law and the prerequisites for its formation should be studied within the framework of scientific approaches characteristic of the modern stage of existence of post-non-classical science (systemic, historical-legal, axiological, epistemological, functional). It is pointed out that the scientific works of leading philosophers from the stage of classical science to the present day contain the methodological and theoretical foundations for constructing the concept of Military Law as a branch of law and a social phenomenon. The result of the discussion is the substantiation of the philosophical foundations of Military Law, as well as the conceptualization of philosophical ideas as sources of the theoretical structure of Military Law. Provisions are put forward to continue philosophical research in the field of Military Law to substantiate its methodological platform and theoretical basis.
Russian-Chinese round table “Modern legal science and education in Russia and China”
Authors: Krotkova Natalya V.
Published: September 2024

The Round Table addresses issues of modern legal education and legal science in Russia and China. It is noted that in these countries, legal education and legal science are going through a transitional period. In both Russia and China, the introduction of market mechanisms and extensive contact with the West have led to the transformation of jurisprudence. Scientists and teachers faced the problem of adapting the national legal tradition to new historical conditions. The comparative analysis of Russia and China is also interesting because both states have a socialist past, and the legal system, legal science and legal education of China have experienced a noticeable influence of the USSR.
Caracterización química, actividad bactericida y antioxidante de ácidos biliares presentes en la bilis de bovinos
Authors:   Cristian Camargo-Pereira, Camargo-Pereira Cristian , Guzmán-Terán Camilo ,   Universidad de Córdoba, Causil-Espitia Karina ,   Universidad de Córdoba, Montaño-Castañeda Mary Cecilia ,   Universidad Nacional de Colombia, Calderón Rangel Alfonso ,   Universidad de Córdoba
Published: September 2024

Los ácidos biliares son biomoléculas con esqueleto esteroidal presentes en la bilis animal y humana, sintetizada en el hígado, a partir de la descomposición del colesterol y luego metabolizados por el microbiota intestinal. Se les atribuyen propiedades biológicas, farmacológicas, anticancerígena, antimicrobiana y terapéuticas; también exhiben efectos bacteriostáticos y bactericidas afectando a géneros, como Staphylococcus, Balantidium, Pneumococcus y Enterococcus; sin embargo, hay pocos estudios con actividad antioxidante apreciable. Por lo tanto, se extrajeron e identificaron químicamente los ácidos biliares aislados de la bilis de bovino (Bos), para determinar su potencial antioxidante y bactericida. Los ácidos biliares fueron derivatizados como ésteres metílicos y analizados mediante cromatografía de gases, acoplada a espectrometría de masas. La actividad bactericida se evaluó frente a Staphylococcus aureus y Pseudomona aeruginosa por el método de microdilución, con concentraciones entre 250 - 4000 μg/mL. El potencial antioxidante fue evaluado frente al radical libre 2,2-difenil-1-picrilhidracilo, a una concentración de 100 μg/mL. Los resultados mostraron la presencia de tres ácidos biliares: ácidos cólicos, ácido desoxicólico y ácido 7alfa-hidroxi-3-oxo-colan-24-oico. La inhibición del crecimiento bacteriano se alcanzó, en su totalidad, con los dos microorganismos evaluados, aún a la concentración más baja utilizada (250 μg/mL). La actividad antioxidante de los ácidos biliares frente al radical DPPH fue muy baja, presentándose un potencial de reducción de 8,9 % a la concentración utilizada. Esta investigación permitió contribuir con el estudio de las actividades biológicas y químicas de los ácidos biliares.
Early-Stage Moderate Alcohol Feeding Dysregulates Insulin-Related Metabolic Hormone Expression in the Brain: Potential Links to Neurodegeneration Including Alzheimer’s Disease
Authors: Yang Yiwen , Tong Ming , de la Monte Suzanne M.
Published: September 2024

Background:

Alzheimer’s disease (AD), one of the most prevalent causes of dementia, is mainly sporadic in occurrence but driven by aging and other cofactors. Studies suggest that excessive alcohol consumption may increase AD risk.

Objective:

Our study examined the degree to which short-term moderate ethanol exposure leads to molecular pathological changes of AD-type neurodegeneration.

Methods:

Long Evans male and female rats were fed for 2 weeks with isocaloric liquid diets containing 24% or 0% caloric ethanol ( n = 8/group). The frontal lobes were used to measure immunoreactivity to AD biomarkers, insulin-related endocrine metabolic molecules, and proinflammatory cytokines/chemokines by duplex or multiplex enzyme-linked immunosorbent assays (ELISAs).

Results:

Ethanol significantly increased frontal lobe levels of phospho-tau, but reduced Aβ, ghrelin, glucagon, leptin, PAI, IL-2, and IFN- γ.

Conclusions:

Short-term effects of chronic ethanol feeding produced neuroendocrine molecular pathologic changes reflective of metabolic dysregulation, together with abnormalities that likely contribute to impairments in neuroplasticity. The findings suggest that chronic alcohol consumption rapidly establishes a platform for impairments in energy metabolism that occur in both the early stages of AD and alcohol-related brain degeneration.
Small Molecule Decoy of Amyloid-β Aggregation Blocks Activation of Microglia-Like Cells
Authors: Oasa Sho , Chen Gefei , Schultzberg Marianne , Terenius Lars
Published: September 2024

Background: Aggregated forms of the amyloid-β (Aβ) peptides which form protofibrils and fibrils in the brain are signatures of Alzheimer’s disease (AD). Aggregates are also recognized by microglia, which in early phases may be protective and in later phases contribute to the pathology. We have identified several small molecules, decoys which interfere with Aβ oligomerization and induce other aggregation trajectories leading to aggregated macrostructures which are non-toxic. Objective: This study investigates whether the small-molecule decoys affect microglial activation in terms of cytokine secretion and phagocytosis of Aβ peptide. Methods: The effects of the decoys (NSC 69318, NSC 100873, NSC 16224) were analyzed in a model of human THP-1 monocytes differentiated to microglia-like cells. The cells were activated by Aβ40 and Aβ42 peptides, respectively, and after treatment with each decoy the secreted levels of pro-inflammatory cytokines and the Aβ phagocytosis were analyzed. Results: NSC16224, which generates a double-stranded aggregate of thin protofibrils, was found to block Aβ40- and Aβ42-induced increase in microglial secretion of pro-inflammatory cytokines. NSC 69318, selective for neurotoxicity of Aβ42, and NSC 100873 did not significantly reduce the microglial activation in terms of cytokine secretion. The uptake of Aβ42 was not affected by anyone of the decoys. Conclusions: Our findings open the possibility that the molecular decoys of Aβ aggregation may block microglial activation by Aβ40 and Aβ42 in addition to blocking neurotoxicity as shown previously.
Effect of polyphenols on inflammation related to cognitive function: a systematic review and meta-analysis of human randomized controlled trials
Authors: Mekhora Chusana , Lamport Daniel J. , Spencer Jeremy P.E.
Published: September 2024

BACKGROUND:

The decline of cognitive function could in part be caused by an increase in inflammation. Polyphenols have been widely investigated due to their anti-inflammatory property which may promote therapeutic effects on the brain and cognitive performance.

OBJECTIVE:

To evaluate the impact of polyphenols interventions on inflammation related to cognitive function in humans.

METHODS:

Three electronic databases: PubMed/Medline, Web of Science and PsycINFO were systematically searched until 30th May 2024 to find the study that have investigated the effect of polyphenols on both inflammatory response and cognitive function in human randomized controlled trials. The outcomes were pooled and calculated using inverse variance as mean difference (MD) with 95% confidence intervals (95% CI) for the inflammatory markers and standardized mean difference (SMD) with 95% CI for cognitive domains.

RESULTS:

Ten studies (451 participants, aged 20–81 years) assessed inflammatory markers and cognitive standardized tests responding to polyphenols interventions were included in this review and meta-analysis. Supplementation with polyphenols demonstrated a significant improvement of verbal memory (SMD: 0.33, 95% CI: 0.12 to 0.54, P = 0.002), executive function (SMD: 0.38, 95% CI: 0.03 to 0.72, P = 0.03) and attenuation in blood interleukin-6 (MD: – 1.23 pg/ml, 95% CI: –2.34, to –0.12, P = 0.03). No significant differences were observed in working memory (SMD: 0.13, 95% CI: –0.18 to 0.44, P = 0.42), attention (SMD: –0.19, 95% CI: –0.84 to 0.46, P = 0.57), and psychomotor skill (SMD: 0.09, 95% CI: –0.32 to 0.50, P = 0.66) as well as in c-reactive protein (MD: –0.10 mg/l, 95% CI: –0.28 to 0.09, P = 0.30), and tumor necrosis factor- α (MD: 0.11 pg/ml, 95% CI: –1.25 to 1.47, P = 0.87).

CONCLUSION:

Polyphenols supplementation decreases blood IL-6 as well as enhances verbal memory and executive function. Regular polyphenols consumption might prevent inflammation related to cognitive decline.
Achieving Sustainability in Banking through Smart Product-Service Systems: An Integrated Robust Fuzzy DEMATEL
Authors: Hu Ya-Ping , Lin Chun-Wei , Hariyadi Eko
Published: September 2024

This article explores the integration of the Triple Bottom Line concept in Smart Product Service Systems (S-PSS) within the banking industry. It emphasizes the importance of balancing economic, social, and environmental factors for sustainable development. By implementing personalized solutions and environmentally friendly practices, banks can strengthen customer relationships, drive loyalty, and reduce their ecological footprint. The study also highlights the benefits of effective information interaction and the potential for new financial services that prioritize economic value, societal well-being, and environmental conservation. Overall, the document provides a comprehensive framework for sustainable business practices in the banking sector.
Perlindungan Hukum Akibat Wanprestasi Dalam Perjanjian Kredit Macet Dengan Jaminan Sertifikat Tanah
Authors: Ghean Niagara Serena , Nur Hidayat Candra
Published: September 2024

Kredit macet dapat menunda kesempatan bank untuk memperoleh pendapatan bunga maupun menerima kembali hutang pokok. Oleh karena itu, dapat diambil jalan penyelesaian yang terbaik antara bank sebagai kreditur dengan debitur. Adapun permasalahan dalam penelitian ini adalah Apa saja Faktor yang menyebabkan debitur melakukan wanprestasi dalam perjanjian kredit. Apakah prosedur penyelesaian wanprestasi pada Putusan Perkara Nomor 10/Pdt.G.S/2020/PN.Pya sudah sesuai menurut Undang-Undang Nomor 37 Tahun 2004 Tentang Penundaan Kewajiban Pembayaran Utang. Metode penelitian yang digunakan adalah penelitian yuridis normatif. Hasil penelitian bahwa adanya itikad baik dari Debitur untuk membayarkan hutang-hutangnya, Debitur dalam keadaan tidak berdaya dikarenakan usaha yang Debitur kelola sedang mengalami pailit, karena kasus covid-19 yang semakin melonjak pada tahun 2020 seharusnya pihak Debitur mendapatkan kesempatan untuk membayarkan hutang-hutangnya dengan cara yaitu: Pihak Debitur dapat meminta penundaan pembayaran hutang kepada pihak Kreditor, Belum adanya dana untuk biaya pengurusan dan pemberesan harta pailit, Meminta untuk penjadwalan kembali mengenai keringanan permasalahannya melalui jalur perdamaian yang telah diatur pada BAB III Bagian Kesatu Penundaan Kewajiban Pembayaran Utang, yang diatur pada Pasal 222, ayat (2) dan ayat (3).
Wanprestasi Perjanjian Kerja Antara Aktor dengan Rumah Produksi Film
Authors: Dhiafajaazka Siti , Rahmatiar Yuniar , Abas Muhamad
Published: September 2024

Perjanjian merupakan tindakan hukum yang terbentuk melalui kesepakatan, di mana beberapa pihak secara bebas menyatakan keinginan mereka. Terwujudnya kesepakatan ini tergantung pada pelaksanaan hukum sebagai kepentingan satu pihak terhadap pihak lain melalui pengaturan aturan yang ada. Dalam konteks perjanjian kerja, diperlukan kontrak yang mengikat kedua belah pihak, sehingga kewajiban mereka dapat dipenuhi. Pada bulan Februari 2020, rumah produksi film Falcon Picture mengajukan gugatan wanprestasi melalui nomor perkara 171/Pdt.G/2020/PN Jkt.Sel terhadap aktor Jefri Nichol, atas pelanggaran perjanjian kerja No. 130/F.05.01/IV/2018 yang disepakati pada tanggal 4 April 2018. Penelitian ini menggunakan metode kualitatif dengan pendekatan yuridis normatif, yaitu metode hukum yang menggunakan data sekunder atau bahan pustaka. Tujuan penelitian ini adalah untuk melihat akibat hukum dari pelanggaran perjanjian kerja dan upaya penyelesaiannya sebagai perlindungan bagi pihak yang terlibat. Berdasarkan pertimbangan hakim, Jefri Nichol dan ibunya terbukti melakukan wanprestasi dengan tidak memenuhi kewajibannya terhadap Falcon Picture dan melanggar Perjanjian Kerja yang telah disepakati. Upaya penyelesaian wanprestasi dilakukan melalui tuntutan ganti rugi Falcon Picture kepada Jefri Nichol melalui jalur litigasi atau pengadilan. Jefri Nichol dan ibunya mencoba mengajukan eksepsi sebagai bentuk perlindungan, namun majelis hakim menolaknya karena bertentangan dengan perjanjian kerja yang telah disepakati.
Kepastian Hukum Putusan Hakim yang Mengabulkan Gugatan Wanprestasi Tanpa Didahului Surat Somasi
Authors: Afendy Kosim
Published: September 2024

Wanprestasi terjadi bila para pihak yang terikat dalam perjanjian baik secara sengaja atau tidak melalaikan atau tidak melaksanakan isi perjanjian sebagaimana mestinya. Menurut Pasal 1243 KUHPer mengatur debitur baru akan diwajibkan untuk ganti rugi apabila telah ada pernyataan lalai. Pernyataan lalai tidak hanya untuk menetapkan suatu tindakan wanpretasi, tetapi juga untuk menentukan hak-hak kreditur. Jadi, maksud â€œberada dalam keadaan lalaiâ€ ialah peringatan atau pernyataan dari kreditur tentang selambat-lambatnya debitur wajib memenuhi prestasi. Apabila saat ini dilampauinya, maka debitur ingkar janji (wanprestasi)
Perlindungan Hukum Terhadap Konsumen Akibat Wanprestasi dalam E-Commerce Ditinjau dari Undang-Undang Nomor 8 Tahun 1999 Tentang Perlindungan Konsumen
Authors: Rahmani Hasanah Imma
Published: September 2024

Suatu perjanjian adalah suatu peristiwa dimana seseorang berjanji kepada orang lain  atau   dimana  dua  orang  itu  saling  berjanji  untuk  melaksanakan  suatu perjanjian. Perjanjian adalah suatu hubungan hukum mengenai harta benda antara dua pihak, dalam mana suatu pihak  berjanji atau dianggap berjanji melakukan sesuatu hal. Penelitian ini berjudul  Perlindungan  Hukum Terhadap Konsumen Akibat  Wanprestasi  Dalam  Transaksi  Elektronik  Logam  Mulia  Ditinjau  Dari Undang-Undang Nomor 8 Tahun 1999 Tentang Perlindungan Konsumen. Adapun tujuan penelitian ini agar mengetahui bagaimana perlindungan terhadap konsumen dalam  bertaransaksi  secara  elektronik  jika  terjadi  wanprestasi.  Penelitian  ini menggunakan metode  penelitian secara empiris atau secara lapangan dan didukung oleh sumber data primer sebagai  kajian kepustakaan meliputi Undang-Undang Nomor 8 Tahun 1999 Tentang Perlindungan  Konsumen. Dalam penelitian ini menerpakan pendekatan lapangan dengan cara wawancara dan observasi kepada pihak-pihak yang melakukan transaksi. Ketentuan-ketentuan yang melindungi hak- hak konsumen dalam peraturan perundang-undangan tersebut belum dimanfaatkan dengan baik oleh konsumen yang mengalami wanprestasi. Dengan  perkembangan  internet  pada  saat  ini,  maka  terbangun  sebuah  sistem perdagangan  dunia  maya.  E-Commerce atau  perniagaan  elektronik merupakan semua bentuk transaksi perdagangan barang ataupun jasa yang menggunakan media perantara internet. Dengan belanja online atau secara elektronik ini, memudahkan banyak pihak dalam hal bertransaksi. Akan tetapi  tetap saja, orang yang ingin bertindak curang masih banyak di sekitar kita. Sehingga hukum  Indonesia pun menyiapkan Undang–Undang untuk menjerat pelaku penipuan dalam transaksi elektronik  (e-commerce).  Penelitian  ini  menyimpulkan  dalam  transaksi  secara elektronik harus tetap mengacu terhadap undang-undang sebagai pedoman dalam penerapan  aturan  hukum,  dan  terhadap pihak-pihak  yang  melakukan  kegiatan tersebut harus bertanggung jawab serta apabila terjadi wanprestasi dalam kegiatan transaksi tersebut maka harus diselesaikan tanpa merugikan pihak lainnya.
GAMBARAN TINGKAT KEMANDIRIAN LANSIA DALAM PEMENUHAN ACTIVITY DAILY LIVING DI PANTI WELAS ASIH SINGAPARNA TASIKMALAYA
Authors: NOVIATI ELIS , Mulyady Endrian , Kurniawan Rudi , Kurniawan Efik
Published: September 2024

Tujuan: Untuk menilai tingkat kemandirian lansia di Panti Welas Asih Singaparna Tasikmalaya dalam melakukan aktivitas kehidupan sehari-hari.
Metode: Metode penelitian ini adalah menggunakan metode deskriptif kuantitatif. Teknik sampel yang digunakan dalam penelitian ini adalah total sampling dengan jumlah sampel sebanyak 31 lansia yang tinggal di Panti Welas Asih Tasikmalaya. Penelitian ini dilakukan pada bulan Juni 2023. Instrumen penelitian menggunakan kuesioner.
Hasil: Hasil penelitian ini menunjukkan kategori mandiri yaitu 7 orang (22,6%), tergantung paling ringan yaitu 2 orang (6,5%), tergantung ringan yaitu 6 orang (19,4%), tergantung sedang yaitu 4 orang (12,9%), tergantung berat yaitu 4 orang (12,9%), tergantung paling berat yaitu 4 orang (12,9%), dan tergantung total yaitu 4 orang (12,9%).
Simpulan: Tingkat kemandiran ADL di Panti Welas Asih Singaparna Tasikmalaya memiliki kategori mandiri yaitu 7 orang (22,6%), sedangkan sisanya sebanyak 24 orang (77,4%) tergolong kedalam kategori ketergantungan dengan kategori ketergantungan paling ringan sampai ketergantungan total.
Bamboo Reinforcement: An Eco-Friendly Composite to Steel Reinforcement
Authors: Javed Hassan , Hussain Saddam , Moiz Shifa , Ahmed Zaheer
Published: September 2024

The use of steel material has increased in developing countries causing surges in prices and affecting the environment. Researchers are endeavouring to find better and eco-friendly materials like bamboo as a better alternative to be used as reinforcement in concrete construction. This research purpose is to examine bamboo as a reasonable substitute for conventional steel serving as a reinforcement in concrete beams. Nine concrete cubes and prisms, and nine Bamboo-Reinforced Concrete Beams (BRCB) designed are subjected to compression testing. For longitudinal reinforcement, T12 steel rebars are utilized while for shear reinforcement R3 bars are used. Also, Bamboo-Reinforced Concrete Beams BCRBs are experimented with using longitudinal bars having a diameter of 20 mm and 8 mm thick steel bars. The results obtained show that bamboo is a viable alternative material and can be efficiently used as reinforcement in concrete beams in place of steel bars average strength is 34 Mpa. However, bamboo poles should be utilized in concrete construction rather than using bamboo slats because of severe durability concerns. There is a need to further investigate bamboo material to enhance its strength and durability while it is being used as a reinforcing material in concrete beams. This could be done by improving the treatment processes, examining the composite materials, or exploring new ways to improve bamboo efficiency and lifespan in concrete construction.
The Antibiotic Prescribing Practices of Gynecologists in Abdominal Hysterectomy
Authors: Tjokroprawiro Brahmana Askandar , Khoirunnisa Novitasari  , Ulhaq Renata Alya , Aldika Akbar Muhammad Ilham
Published: September 2024

Objective: To evaluate the pattern of antibiotics used for abdominal hysterectomy by gynecologists in infected and non-infected cases.
Methods: Data was collected through an online survey of gynecologists in Surabaya, Indonesia.
Results: A total of 200 gynecologists were involved in this study. All of them used prophylactic antibiotics in all cases of abdominal hysterectomy, and the most commonly used was cefazoline (70.5%), followed by ceftriaxone (15.5%) and cefotaxime (9%). Most gynecologists (68%) gave 2 grams of prophylactic antibiotic, and 79,5% of antibiotics were administered within 30 minutes before surgery. Additional antibiotics during surgery were given in prolonged surgery (79.01%) and intraoperative bleeding > 1500 mL (48.14%). The most common additional dosage used was 1 gram (72.9%), and most gynecologists (37.2%) continued antibiotics for one day ahead. The type of therapeutic antibiotics used for infected cases was varied, consisting of ceftriaxone (50.5%), metronidazole (42%), cefotaxime (17%), cefazoline (15.5%), gentamicin (12%), ampicillin-sulbactam (4%), and amoxicillin-clavulanic acid (3.5%). Most gynecologists (43.7%) gave these antibiotics for three days.
Conclusion: The majority of gynecologists in Surabaya already use prophylactic antibiotics for abdominal hysterectomy and therapeutic antibiotics for infected cases following the existing guidelines
Multidisciplinary Approach of Placenta Accreta Spectrum Management to Reduce Blood Loss and Prevent Organ Injury in Referral Center
Authors: Nugraha Gagah Baskara Adi , Yuliantara Eric Edwin
Published: September 2024

Objective: To investigate the differences in blood loss and organ injury at our PAS referral center over the past six years.Methods: This retrospective analytical study included 150 subjects diagnosed with PAS based on histopathological findings from 2018 to 2023 at the PAS Center of Dr. Moewardi Regional Hospital, Surakarta, Indonesia. Subjects were divided into two groups: before 2020 and after 2021, based on multidisciplinary team appointments.Results: The highest number of Placenta Accreta Spectrum (PAS) cases occurred in 2020, with 36 patients. Hysterectomy was the most frequently performed procedure for managing PAS in all groups. However, differences in blood loss, organ injury, and length of hospital stay between the periods from 2018 to 2020 and 2021 to 2023 were statistically significant (p < 0.05).Conclusion: Multidisciplinary approaches involving various medical specialties and teams are essential to ensure maternal safety and effectively manage massive blood loss and organ damage during PAS surgery procedures.Keywords: Placenta accreta spectrum, Blood loss reduction, Organ injury prevention.
Clathrin-Mediated Endocytosis Is Regulated
Authors: Rahmani Sadia
Published: September 2024

Clathrin-mediated endocytosis (CME) is a multifunctional biological process involved in internalization of receptors, viruses, and nutrients from the cell surface. CME has important implications for different cell surface proteins such as Receptor Tyrosine Kinases that regulate growth, adhesion, and migration. In turn, CME is highly regulated to control the abundance of cell surface proteins under different physiological requirements of the cell. I examined how the modification of proteins with O-linked N-acetyl-glucosamine (O-GlcNAc) may control CME. I used perturbation of key enzymes responsible for protein O-GlcNAc modification, as well as specific mutants of the central endocytic regulator. I identified that initiation and the assembly of clathrin and other proteins is controlled by O-GlcNAc protein modification. This reveals a new dimension of regulation of CME and highlights the important reciprocal regulation of cellular metabolism and endocytosis. The dynamic O-GlcNAc modification is added by O-GlcNAc transferase (OGT) and removed by O-GlcNAc hydrolase within nucleus and cytoplasm. OGT is a nutrient sensor amongst others such as AMP-Activated Protein Kinase (AMPK) that may fine-tune cellular responses to stress stimuli. I define the metabolic conditions in which OGT and AMPK are reciprocally regulated thus revealing the cooperativity and signaling crosstalk between the nutrient sensors. Having established a key role for the dynamic O-GlcNAc modification, I also explored the synthetic modification of cell surface glycoproteins with an elaborate polymer of the sugar sialic acid. Using a recombinant bacterial enzyme for synthesis of poly-α±2,8-N-acetylneuraminic acid (polysialic acid; PolySia) onto cardiomyocytes increased their propensity for persistent directional cellular migration. As such, my work characterizes the cellular effects of synthetic PolySia for cellular therapy.
أثر برنامج تعليمي باستخدام الوسائط فائقة التداخل في تعلم وانجاز الوثبة الثلاثية للطلاب
Authors: Abdul Ali Obaid Al-Fartousi
Published: September 2024

تبلورت مشكلة البحث في استثمار عدد الوحدات التعليمية المخصصة لفعالية الوثب الثلاثية في رفع كمية التعلم التطبيقي والمعرفي وذلك باستخدام برنامج (Hypermedia) .
وكانت أهداف البحث هي :
1- إعداد برنامج تعليمي باستخدام الوسائط فائقة التداخل لفعالية الوثبة الثلاثية .
2- معرفة اثر البرنامج التعليمي المقترح باستخدام الوسائط فائقة التداخل في تعلم واحتفاظ فعالية الوثبة الثلاثية (الأداء الفني والانجاز) لدى طلاب كلية التربية البدنية وعلوم الرياضة . الجامعة المستنصرية  .
وبما يخص إجراءات البحث حيث كانت عينة البحث طلاب كلية التربية البدنية وعلوم الرياضة . الجامعة  المستنصرية  وكذلك على خطوات إعداد وسائط فائقة التداخل بالإضافة إلى اختبارات الأداء الفني والانجاز وعلى ضوء هذا فقد استخدم الباحث المنهج التجريبي بتصميم (المجموعات المتكافئة)  وكذلك استخدم الوسائل الإحصائية وكان أهمها اختبار ليفين , اختبار (t) للعينات المرتبطة , اختبار (t) للعينات المستقلة .
وأخيرا توصل الباحث إلى عدة استنتاجات منها :
1- حقق البرنامج المعد باستخدام وسائط فائقة التداخل تحسنا معنويا في مستوى الاداء الفني والانجاز في فعالية الوثبة الثلاثية لدى إفراد المجموعة التجريبية .
2- حقق البرنامج المعد وسائط فائقة التداخل احتفاظاً جيداً  لدى إفراد المجموعة التجريبية .
Hubungan MPASI dengan Stunting : Literature Review
Authors: Pinanggih Sukma Rahayu , Fatmaningrum Widati
Published: September 2024

Status gizi anak di bawah usia lima tahun merupakan indikasi yang sangat baik untuk gizi, kesehatan, dan kesejahteraan sosial secara keseluruhan karena stunting adalah jenis kekurangan gizi yang membutuhkan waktu lama bagi anak untuk pulih meskipun diobati dengan segera. Menghentikan stunting membutuhkan keakraban dengan penyebabnya. Mulai usia 6 bulan, MPASI sangat penting dalam memastikan balita memperoleh asupan gizi, dan tingkat pendidikan ibu berpengaruh besar terhadap pola asuh dan pemahaman ibu terhadap kebutuhan gizi anaknya. Metode yang digunakan untuk penelitian ini adalah metode tinjauan pustaka (literature review). Hasil menunjukkan pemberian makanan tambahan (MPASI) dan tingkat stunting saling berhubungan. Temuan studi literature review ini mengungkapkan bahwa prevalensi stunting lebih tinggi pada balita yang mengkonsumsi zat besi dan protein secara tidak seimbang, bahwa prevalensi stunting pada balita erat kaitannya dengan pemberian ASI eksklusif, dan pemberian makanan pendamping ASI yang tepat dapat menurunkan angka kejadian stunting.
Penguatan Kesadaran Politik Pada Generasi Muda dalam Menghadapi Pilkada Tahun 2024 di Kabupaten Majene
Authors: Tamrin Saddam Husain , Tahir Arifin , Syahrinullah Syahrinullah , Rakasiwi Fajar , Ulfa Maria , Bhayangkari Ika Yuli , Sajidin Muhammad , Mu'min Mu'min , Farhanuddin Farhanuddin
Published: September 2024

Pengabdian kepada masyarakat ini bertujuan untuk memberikan penguatan kesadaran politik pada generasi muda dalam menghadapi Pilkada serentak tahun 2024 di Kabupaten Majene. Kurangnya partisipasi generasi muda di kabupaten majene karena kurangnya informasi yang diperoleh generasi muda. Pengabdian ini bermitra dengan Bakesbangpol dan KPU Kabupaten Majene, dengan melibatkan dosen dan mahasiswa universitas terbuka dan Universitas Sulawesi Barat, dengan tahapan 1) Persiapan; 2) Koordinasi dengan mitra strategis; 3) Pelaksanaan Focus Group Discusion 4) Melaksanakan Sosialisasi penguatan kesadaran politik pada generasi muda dalam menghadapi Pilkada tahun 2024 di kabupaten majene. Hasil yang diperoleh dalam kegiatan ini adalah meningkatnya pemahaman terkait pentingnya politik sehingga berdampak pada kesadaran dan partisipasi politik pada generasi muda di Kabupaten Majene dalam menghadapi Pilkada serentak tahun 2024.
Ensuring Peace, Public Order and Stability In The Context of Preventing Violence In Islamic Urban Design and City Planning
Authors: Demir Mehmet Emin
Published: September 2024

Islamic cities exhibit distinctive features aimed at preventing violence, promoting human well-being, and safeguarding the rights of individuals. These characteristics encompass deliberate choices in urban planning and governance. Key attributes include a mosque-centric layout, expansive public squares, green spaces, organized urban fabric, and efficient administrative management. The maintenance of public order was entrusted to the head of state in the capital and governors in other regions, with additional officials such as commanders, ḳāḍīs (judges), Muḥtasib (market overseer), Ṣāḥib al-S̲h̲urṭa (chief of police), and ʿasas (security officers) appointed to ensure security and peace. Akhism provide additional assistance at this stage. This research will delve into Islamic cities' physical infrastructure and institutional framework, focusing on violence prevention. Given Islamic urbanism's diverse geographical spread and historical evolution, the study will analyze select early-period cities, considering urban plans and administrative systems to facilitate comparative analysis.
Isaiah Berlin’in Özgürlük Kuramı Bağlamında Özgürlük-Din İlişkisi Üzerine Bir Değerlendirme
Authors: Karadağ Nazım , Eroğlu Gültekin
Published: September 2024

Bu çalışma, özgürlük tartışmalarına girmiş olan Rus asıllı, İngiliz vatandaşı, felsefeci ve siyaset bilimcisi Isaiah Berlin’in iki özgürlük kavramı tezi çerçevesinde din ve özgürlük ilişkisini tartışma konusu yapmaktadır. Makalede negatif özgürlük ve pozitif özgürlük arasında dinin konumu tartışılmaktadır. Isaiah Berlin’in “Two Concepts of Liberty” adlı makalesi çalışmanın ana kaynağı olmuştur. Berlin, negatif özgürlük ve pozitif özgürlük şeklinde iki özgürlük türü belirleme gayreti içerisine girer, ancak sonrasında her iki özgürlüğün tam olarak birbirinden kesin ifadelerle ayrılamayacağını belirtir. Bir şeyi yaparken engellenmemek negatif özgürlük iken bir şeyi yapmak için özgür olmak talebi pozitif özgürlük olarak belirtildiğinde, din özgürlüğü nasıl konumlanır? İki özgürlük arasında din nerede olur? Bu sorunun cevabı, bir problemi doğurmaktadır. Negatif ve pozitif özgürlük tam olarak tanımlanamadığından ve her iki özgürlüğün sorun teşkil eden yönlerinden dolayı din iki özgürlük arasında tam olarak yer edinemeyecektir. Öyle ki, Berlin’in kendisi de makalesinde din olgusuna pek fazla değinmez. Değindiği kadarıyla aktardığı bilgi ise dinin iki özgürlük arasındaki yerini belirlemeye yetecek düzeyde değildir. Bu nedenle Isaiah Berlin’in yeterince temas etmediği din ve iki özgürlük ilişkisi bu makalede derinlemesine ele alınıp incelenmeye çalışılmıştır.
Validating The Self-Talk Questionnaire of Athletes and How it Affects Athletes’ Mental Toughness?
Authors: Haqiyah Aridhotul , Riyadi Dani Nur , Bujang Bujang , Abidin Dindin , Putra Purnama , Lubis Johansyah , Bahtra Ridho , Soeharto Soeharto , Hanief Yulingga Nanda , Lestari Wahyu Dwi , Taufik Muhamad Syamsul , Muslim Budi Ariyanto
Published: September 2024

This research could have significant implications for improving mental conditioning practices in sports. By establishing the validity of this questionnaire, researchers and coaches can better understand the relationship between self-talk and mental toughness, leading to more effective interventions and training programs that enhance athletes' resilience and competitive edge. This study aimed to validate its psychometric properties to detect the self-talk of athletes and how it affects their mental toughness. The participants were 93 Athlete in martial arts and game sports (83 Male and 10 Female with Age; M=24.35, SD=7.338) in Bekasi, Indonesian athletes. Data were collected randomly in an online form. Rasch analysis was utilized to evaluate the validity and reliability of the self-talk questionnaire in the Indonesian version with 5 Likert scales, and linear regression was used for hypothesis analysis. The results showed that the self-talk questionnaire in the Indonesian version achieved validity and reliability criteria based on Rasch parameters with five rating scales. The questionnaire data revealed strong positive connections between self-talk and mental toughness. Challenge had the largest effect on negative self-talk, while control had the largest effect on positive self-talk. In conclusion, self-talk has a significant impact on athletes’ mental toughness.
ANALYSIS OF SOCIAL MEDIA MARKETING STRATEGY (GOFOOD) IN INCREASING CONSUMERS AT WARUNG SOTO PAK KOYA KRAKSAAN SHARIA ECONOMIC PERSPECTIVE
Authors: Maula Ismatul
Published: September 2024

Social media marketing strategies have become a crucial element in the development of culinary businesses, playing a key role in acquiring and retaining customers. By leveraging the GoFood platform, Warung Soto Pak Koya has designed and implemented a series of strategies aimed at increasing the number of consumers. This research focuses on Warung Soto Pak Koya, a soto stall located in Kraksaan, and investigates the effectiveness of social media marketing strategies, especially through the GoFood platform, in increasing the number of consumers. The objectives of this research are to understand the social media marketing strategies (GoFood) in increasing consumers at Warung Soto Pak Koya Kraksaan and to determine the impact of GoFood marketing strategies on Warung Soto Pak Koya in enhancing consumer numbers. The research method applied by the author is a qualitative research method through a case study at Warung Soto Pak Koya. Data collection techniques include observation, testing, interviews, and documentation. The results obtained from this research are as follows: the social media marketing strategies through GoFood at Warung Soto Pak Koya Kraksaan include uploading a complete menu, optimizing taste quality, offering special GoFood promotions, and analyzing performance. The impact of social media marketing strategies through GoFood in increasing consumers is positive, although the increase in consumers is not as significant as before using the GoFood platform.
The role of peroxis proliferator-activated receptors in metabolic diseases
Authors: Alekseeva R. I. , Sharafetdinov Kh. Kh. , Plotnikova O. A. , Pilipenko V. V. , Sorokinа E. Yu.
Published: September 2024

Аim: to analyze and summarize literature data on the effect of peroxisome proliferator-activated receptors (PPARs) on cardiometabolic parameters in chronic non-infectious diseases, including type 2 diabetes mellitus.Materials and methods: a comprehensive search was conducted in electronic databases, including PubMed/Medline, Web of Science, Scopus, on the role of peroxisome proliferator-activated receptors (PPAR) on cardiometabolic parameters in type 2 diabetes mellitus.Results: the relevance of research into the identification of structural determinants responsible for the binding and activation of PPAR is shown. Their contributions are particularly relevant in the characterization and optimization of new PPAR modulators of different origins, taking into account their activity, selectivity and safety profiles. Identification of known PPAR agonists found in foods makes a potential contribution to the comprehensive treatment of patients with type 2 diabetes. PPAR receptors play a key role in lipid metabolism and glucose homeostasis, as well as in the prevention and treatment of metabolic diseases.Conclusion: further research on the role of PPAR agonists of various isoforms opens up new perspectives with the use of dietary and drug therapies in a number of metabolic diseases.
Monitoring the nutrition of elementary school students
Authors: Portnov N. M. , Gorelova Zh. Yu. , Ivanova V. N.
Published: September 2024

In Russia, an automated system for monitoring the nutrition of primary school students has been successfully operating for 3 years, in which 39 thousand catering units participate, providing meals to 7.6 million students. The database contains 13.2 million actual nutrition menus and standard menus of 31 thousand catering units, in digital form, available for scientific analysis by nutritionists and commodity experts. Information from the federal monitoring system is used in the operational management of school meals; detected deviations from school consumption standards are used to correct and improve the menu.
Effect of different doses of caffeine on speed and strength parameters of freestyle wrestlers: a pilot study
Authors: Rybakova P. D. , Antonov A. G. , Miroshnikov A. B.
Published: September 2024

The ever-increasing competition in combat sports requires the introduction of optimal nutritional and metabolic support factors. Among popular supplements, caffeine is one of the most consumed substances in the world of sport and is recognised as an ergogenic agent.Objective. To evaluate the effect of different doses of biologically active caffeine supplement on speed and strength performance parameters in freestyle wrestlers.Methods. A cross-sectional study included 5 highly qualified athletes involved in freestyle wrestling. Genetic variations of the CYP1A2 enzyme were determined. In a double-blind method, participants took 60 minutes before testing: placebo; caffeine: 6 mg/kg body weight, 3 mg/kg body weight, and 1.5 mg/kg body weight. Participants performed a 30-second Wingate anaerobic test on a manual ergometer. Oxygen demand and oxygen debt were recorded using a gas analyzer, and blood lactate levels were recorded at 3, 5 and 7 minutes after the end of the test.Results. Caffeine ingestion according to the protocol of 1.5 mg/kg body weight showed no differences compared to placebo. Caffeine administration under the protocol 3 mg/kg body weight decreased oxygen consumption values, while the other parameters were not changed. Caffeine administration under the protocol of 6 mg/kg body weight did not change the time to reach maximal power, oxygen consumption parameters, but power parameters were decreased. Blood lactate was increased at the 7th minute of running compared to the 3rd minute when taking placebo. Caffeine administration at a dosage of 1.5 mg/kg body weight resulted in a significant increase in lactate compared to the 3rd minute, but the changes were not statistically significant. A caffeine dosage of 3 mg/kg body weight resulted in an increase in lactate compared to the 3rd and 5th minute. Caffeine administration at a dosage of 6 mg/kg body weight showed a decrease to its baseline level at the 7th minute.Conclusions. Wrestlers did not improve speed and strength performance and recovery after caffeine ingestion in the 30-second Wingate anaerobic manual ergometer test.
EDUCACIÓN ARTÍSTICA Y MUSEOS EN CLAVE DE GÉNERO: ESPACIOS DE APRENDIZAJE E IMAGINARIOS VISUALES EN CONSTRUCCIÓN
Authors: Abad De Los Santos Belén
Published: September 2024

Este artículo propone una reflexión sobre los museos como espacios de aprendizaje derivada de una investigación que busca conocer su potencialidad didáctica dentro del marco de una práctica formativa universitaria llevada a cabo en colaboración con el Centro Andaluz de Arte Contemporáneo (CAAC) en 2024, motivada por la exposición Malgorzata Mirga-Tas. Remembranza y resignificación. El itinerario seguido trató de ofrecer orientaciones a los discentes del MAES de la Universidad de Sevilla que facilitaran la interpretación de las creaciones de la artista y activista romaní Malgorzata Mirga-Tas, bajo las que subyace un marcado trasfondo político y feminista. Tras el balance de la experiencia museística se focalizará la atención en la valoración de su impacto.
Deep Back Massage sebagai Metode Penanganan Nyeri Persalinan
Authors: Kartika Ira , Trisiani Desi , Herawati Yanti , Rahmawati Nur Syifa
Published: September 2024

Banyak penyebab yang mengakibatkan terjadinya nyeri dalam persalinan, nyeripersalinan adalah hal yang normal tetapi kadang bisa menyebabkan trauma yangberlebihan pada ibu bersalin. Nyeri persalinan yang berlebihan menyebabkan strespada ibu bersalin yang dapat meningkatkan nadi dan respirasi sehingga mengganggupasokan oksigen ke jan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruhdeep black masasse terhadap penurunan nyeri persalinan Metode penelitianmenggunakan quasi eksperimen dengan desain pre-test dan post-test. sampel yangdigunakan sebanyak 30 ibu bersalin kala 1 fase aktif dimana 15 sebagai kelompokintervensi dan 15 orang sebagai kelompok kontrol, intrumen penelitian menggunakannumeric rating scale, Analisa bivariat menggunakan Uji Wilcoxon. Hasil penelitianKelompok intervensi sebelum dilakukan perlakuan didapatkan mengalami nyeri sedangsebanyak 13 (86,7%) dan berat sebanyak 2 (13,3%) dan pada kelompok kontrol, yangmengalami nyeri ringan 4 (26,7%) responden, nyeri sedang 9 (60%) dan nyeri berat 2(13,3%) responden. sesudah dilakukan intervensi kelompok intervensi menjadi nyeriringan sebanyak 4 (26,7%) responden, yang mengalami nyeri sedang sebanyak 9 (60,0%)responden serta nyeri berat 2 (13,3%) responden dan untuk kelompok kontrol sesudahmenjadi nyeri ringan 2 (13,3 %) responden nyeri sedang 11 (73,4%) responden, nyeriberat 2 (13,3%) responden. Terdapat pengaruh penurunan intensitas nyeri pada kelompokintervensi dengan nilai p-value 0,000 < 0,050).
Therapeutic approaches to CNS diseases via the meningeal lymphatic and glymphatic system: prospects and challenges
Authors: Zhang Rui , Li Jiuhong , Li Xueying , Zhang Si
Published: September 2024

The brain has traditionally been considered an “immune-privileged” organ lacking a lymphatic system. However, recent studies have challenged this view by identifying the presence of the glymphatic system and meningeal lymphatic vessels (MLVs). These discoveries offer new opportunities for waste clearance and treatment of central nervous system (CNS) diseases. Various strategies have been developed based on these pathways, including modulation of glymphatic system function, enhancement of meningeal lymphatic drainage, and utilization of these routes for drug delivery. Consequently, this review explores the developmental features and physiological roles of the cerebral lymphatic system as well as its significance in various CNS disorders. Notably, strategies for ameliorating CNS diseases have been discussed with a focus on enhancing glymphatic system and MLVs functionality through modulation of physiological factors along with implementing pharmacological and physical treatments. Additionally, emphasis is placed on the potential use of the CNS lymphatic system in drug delivery while envisioning future directions in terms of mechanisms, applications, and translational research.
Cathelicidins—a rich seam of antimicrobial peptides waiting for exploitation
Authors: Tossi Alessandro , Gerdol Marco , Caporale Andrea , Pacor Sabrina , Mardirossian Mario , Scocchi Marco , Prickett Michael D. , Manzini Giorgio , Gennaro Renato
Published: September 2024

Cathelicidins are a ubiquitous family of host defence antimicrobial peptides in vertebrate animals. Unlike other antimicrobial peptide families, it is defined by a large and relatively well conserved proregion rather than by the mature bioactive peptides themselves, which are highly diverse and conform to at least five different structural types, resulting in distinct modes of action. Cathelicidin-derived host defence peptides have a pleiotropic role in immunity, displaying both a direct antimicrobial activity and the ability to boost other host responses to infection and injury. The presence of a relatively well conserved proregion attached to a vast repertoire of structurally and functionally diverse peptides allows mining the increasing number of vertebrate genomes for lead sequences to potentially useful new anti-infective and/or immunomodulatory agents. This should increase the number of cathelicidin-based peptides entering clinical trials, which has been limited to date, despite considerable efforts in the last 2 decades.
The global drivers of wildfire
Authors: Haas Olivia , Keeping Theodore , Gomez-Dans José , Prentice I. Colin , Harrison Sandy P.
Published: September 2024

Changes in wildfire regimes are of growing concern and raise issues about how well we can model risks in a changing climate. Process-based coupled fire-vegetation models, used to project future wildfire regimes, capture many aspects of wildfire regimes poorly. However, there is now a wealth of information from empirical studies on the climate, vegetation, topography and human activity controls on wildfire regimes. The measures used to quantify these controls vary among studies, but certain variables consistently emerge as the most important: gross primary production as a measure of fuel availability, vegetation cover as a measure of fuel continuity, and atmospheric humidity as a measure of fuel drying. Contrary to popular perception, ignitions are generally not a limiting factor for wildfires. In this review, we describe how empirical fire models implement wildfire processes, synthesise current understanding of the controls on wildfire extent and severity, and suggest ways in which fire modelling could be improved.
Photonanozyme–Kras–ribosome combination treatment of non-small cell lung cancer after COVID-19
Authors: Si Qiaoyan , Bai Mingjian , Wang Xiaolong , Wang Tianyu , Qin Yan
Published: September 2024

With the outbreak of the coronavirus disease 2019 (COVID-19), reductions in T-cell function and exhaustion have been observed in patients post-infection of COVID-19. T cells are key mediators of anti-infection and antitumor, and their exhaustion increases the risk of compromised immune function and elevated susceptibility to cancer. Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer with high incidence and mortality. Although the survival rate after standard treatment such as surgical treatment and chemotherapy has improved, the therapeutic effect is still limited due to drug resistance, side effects, and recurrence. Recent advances in molecular biology and immunology enable the development of highly targeted therapy and immunotherapy for cancer, which has driven cancer therapies into individualized treatments and gradually entered clinicians’ views for treating NSCLC. Currently, with the development of photosensitizer materials, phototherapy has been gradually applied to the treatment of NSCLC. This review provides an overview of recent advancements and limitations in different treatment strategies for NSCLC under the background of COVID-19. We discuss the latest advances in phototherapy as a promising treatment method for NSCLC. After critically examining the successes, challenges, and prospects associated with these treatment modalities, their profound prospects were portrayed.