bluuebunny/crossref_metadata_2025 huggingface dataset:
Serial tissue Doppler imaging in the evaluation of bronchopulmonary dysplasia-associated pulmonary hypertension among extremely preterm infants: a prospective observational study
Authors: Gopagondanahalli Krishna Revanna , Abdul Haium Abdul Alim , Vora Shrenik Jitendrakumar , Sundararaghavan Sreekanthan , Ng Wei Di , Choo Tze Liang Jonathan , Ang Wai Lin , Binte Mohamad Taib Nur Qaiyimah , Wijedasa Nishanthi Han Ying , Rajadurai Victor Samuel , Yeo Kee Thai , Tan Teng Hong
Published: April 2024

Objectives

To evaluate serial tissue Doppler cardiac imaging (TDI) in the evolution of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) among extremely preterm infants.

Design

Prospective observational study.

Setting

Single-center, tertiary-level neonatal intensive care unit.

Patients

Infant born <28 weeks gestation.

Main outcome measures

Utility of TDI in the early diagnosis and prediction of BPD-PH and optimal timing for screening of BPD-PH.

Results

A total of 79 infants were included. Of them, 17 (23%) had BPD-PH. The mean gestational age was 25.9 ± 1.1 weeks, and mean birth weight was 830 ± 174 g. The BPD-PH group had a high incidence of hemodynamically significant patent ductus arteriosus (83% vs. 56%, p < 0.018), longer oxygen days (96.16 ± 68.09 vs. 59.35 ± 52.1, p < 0.008), and prolonged hospital stay (133.8 ± 45.9 vs. 106.5 ± 37.9 days, p < 0.005). The left ventricular eccentricity index (0.99 ± 0.1 vs. 1.1 ± 0.7, p < 0.01) and the ratio of acceleration time to right ventricular ejection time showed a statistically significant trend from 33 weeks (0.24 ± 0.05 vs. 0.28 ± 0.05, p < 0.05). At 33 weeks, the BPD-PH group showed prolonged isovolumetric contraction time (27.84 ± 5.5 vs. 22.77 ± 4, p < 0.001), prolonged isovolumetric relaxation time (40.3 ± 7.1 vs. 34.9 ± 5.3, p < 0.003), and abnormal myocardial performance index (0.39 ± 0.05 vs. 0.32 ± 0.03, p < 0.001). These differences persisted at 36 weeks after conceptional gestational age.

Conclusions

TDI parameters are sensitive in the early evolution of BPD-PH. Diagnostic accuracy can be increased by combining the TDI parameters with conventional echocardiographic parameters. BPD-PH can be recognizable as early as 33–34 weeks of gestation.
Chemotherapeutic potential of betanin/capecitabine combination targeting colon cancer: experimental and bioinformatic studies exploring NFκB and cyclin D1 interplay
Authors: Ahmed Rehab , Zaitone Sawsan A. , Abdelmaogood Asmaa K. K. , Atef Huda M. , Soliman Mona F. M. , Badawy Alaa M. , Ali Howaida S. , Zaid AbdelNaser , Mokhtar Hatem I. , Elabbasy Lamiaa M. , Kandil Emad , Yosef Asmaa Mokhtar , Mahran Rama I.
Published: April 2024

Introduction: Betanin (C₂₄H₂₆N₂O₁₃) is safe to use as food additives approved by the FDA with anti-inflammatory and anticancer effects in many types of cancer cell lines. The current experiment was designed to test the chemotherapeutic effect of the combination of betanin with the standard chemotherapeutic agent, capecitabine, against chemically induced colon cancer in mice.

Methods: Bioinformatic approach was designed to get information about the possible mechanisms through which the drugs may control cancer development. Five groups of mice were assigned as, (i) saline, (ii) colon cancer, (iii) betanin, (iv) capecitabine and (v) betanin/capecitabine. Drugs were given orally for a period of six weeks. Colon tissues were separated and used for biological assays and histopathology.

Results: In addition, the mRNA expression of TNF-α (4.58-fold), NFκB (5.33-fold), IL-1β (4.99-fold), cyclin D1 (4.07-fold), and IL-6 (3.55-fold) and protein levels showed several folds increases versus the saline group. Tumor histopathology scores in the colon cancer group (including cryptic distortion and hyperplasia) and immunostaining for NFκB (2.94-fold) were high while periodic-acid Schiff staining demonstrated poor mucin content (33% of the saline group). These pathologic manifestations were reduced remarkably in betanin/capecitabine group.

Conclusion: Collectively, our findings demonstrated the usefulness of betanin/capecitabine combination in targeting colon cancer and highlighted that betanin is a promising adjuvant therapy to capecitabine in treating colon cancer patients.
Exploring the role of pyroptosis in the pathogenicity of heart disease
Authors: Bhatti Rohail , Sato Priscila Y.
Published: April 2024

Cell death is an essential cellular mechanism that ensures quality control and whole-body homeostasis. Various modes of cell death have been studied and detailed. Unbalanced cell death can lead to uncontrolled cell proliferation (i.e., tumors) or excessive loss of cells (i.e., ischemia injury tissue loss). Thus, it is imperative for modes of cell death to be balanced and controlled. Here, we will focus on a recent mode of cell death called pyroptosis. While extensive studies have shown the role of this route of cell death in macrophages and monocytes, evidence for pyroptosis have expanded to encompass other pathologies, including cancer and cardiac diseases. Herein, we provide a brief review on pyroptosis and discuss current gaps in knowledge and scientific advances in cardiac pyroptosis in recent years. Lastly, we provide conclusions and prospective on the relevance to various cardiac diseases.
A multi-omic survey of black cottonwood tissues highlights coordinated transcriptomic and metabolomic mechanisms for plant adaptation to phosphorus deficiency
Authors: Kangi Emel , Brzostek Edward R. , Bills Robert J. , Callister Stephen J. , Zink Erika M. , Kim Young-Mo , Larsen Peter E. , Cumming Jonathan R.
Published: April 2024

Introduction

Phosphorus (P) deficiency in plants creates a variety of metabolic perturbations that decrease photosynthesis and growth. Phosphorus deficiency is especially challenging for the production of bioenergy feedstock plantation species, such as poplars (Populus spp.), where fertilization may not be practically or economically feasible. While the phenotypic effects of P deficiency are well known, the molecular mechanisms underlying whole-plant and tissue-specific responses to P deficiency, and in particular the responses of commercially valuable hardwoods, are less studied.

Methods

We used a multi-tissue and multi-omics approach using transcriptomic, proteomic, and metabolomic analyses of the leaves and roots of black cottonwood (Populus trichocarpa) seedlings grown under P-deficient (5 µM P) and replete (100 µM P) conditions to assess this knowledge gap and to identify potential gene targets for selection for P efficiency.

Results

In comparison to seedlings grown at 100 µM P, P-deficient seedlings exhibited reduced dry biomass, altered chlorophyll fluorescence, and reduced tissue P concentrations. In line with these observations, growth, C metabolism, and photosynthesis pathways were downregulated in the transcriptome of the P-deficient plants. Additionally, we found evidence of strong lipid remodeling in the leaves. Metabolomic data showed that the roots of P-deficient plants had a greater relative abundance of phosphate ion, which may reflect extensive degradation of P-rich metabolites in plants exposed to long-term P-deficiency. With the notable exception of the KEGG pathway for Starch and Sucrose Metabolism (map00500), the responses of the transcriptome and the metabolome to P deficiency were consistent with one another. No significant changes in the proteome were detected in response to P deficiency.

Discussion and conclusion

Collectively, our multi-omic and multi-tissue approach enabled the identification of important metabolic and regulatory pathways regulated across tissues at the molecular level that will be important avenues to further evaluate for P efficiency. These included stress-mediating systems associated with reactive oxygen species maintenance, lipid remodeling within tissues, and systems involved in P scavenging from the rhizosphere.
Defense strategies and associated phytohormonal regulation in Brassica plants in response to chewing and sap-sucking insects
Authors: Ali Jamin , Tonğa Adil , Islam Tarikul , Mir Sajad , Mukarram Mohammad , Konôpková Alena Sliacka , Chen Rizhao
Published: April 2024

Plants have evolved distinct defense strategies in response to a diverse range of chewing and sucking insect herbivory. While chewing insect herbivores, exemplified by caterpillars and beetles, cause visible tissue damage and induce jasmonic acid (JA)-mediated defense responses, sucking insects, such as aphids and whiteflies, delicately tap into the phloem sap and elicit salicylic acid (SA)-mediated defense responses. This review aims to highlight the specificity of defense strategies in Brassica plants and associated underlying molecular mechanisms when challenged by herbivorous insects from different feeding guilds (i.e., chewing and sucking insects). To establish such an understanding in Brassica plants, the typical defense responses were categorized into physical, chemical, and metabolic adjustments. Further, the impact of contrasting feeding patterns on Brassica is discussed in context to unique biochemical and molecular modus operandi that governs the resistance against chewing and sucking insect pests. Grasping these interactions is crucial to developing innovative and targeted pest management approaches to ensure ecosystem sustainability and Brassica productivity.
“What do they mean?” a systematic review on the interpretation, usage and acceptability of “they”
Authors: Batista da Costa Mafalda , Tenenbaum Harriet R. , Grandison Alexandra
Published: April 2024

The rise of feminist and LGBTQIA+ movements paved the way for many equality reforms. These include language reforms, which facilitate inclusion of multiple groups in society. For example, the shift from the generic “he” to “he or she” and “they” allows for the inclusion of women, transgender, and non-binary individuals in many narratives. For this reason, many institutions worldwide encourage neutral language. It remains unclear how individuals interpret neutral language. One case of neutral language is the pronoun “they,” which has been assigned multiple definitions from the 1970s to 2022. We examine how the pronoun “they” has been interpreted, used, and accepted over time. We discuss trends in the findings and make suggestions for future research directions, including the need for better methods to investigate pronouns and clarification on what the focus of neutral language should be. This timely commentary has implications for action on equality, diversity, and inclusion.
Servant leadership, brand love, and work ethic: important predictors of general health in workers in the education sector
Authors: Laura-Arias Elena , Villar-Guevara Miluska , Millones-Liza Dany Yudet
Published: April 2024

Background

Building a path aimed at the wellbeing of workers in the education sector is the fundamental basis to encourage quality education. To fill the gap in knowledge and address this aspect by understanding the behavior of the study population, it was proposed as with the objective of determining if servant leadership, brand love and work ethic predict the general health in workers.

Methods

A non-probability sampling was applied for convenience. For this purpose, a sample of 509 workers from Peru was submitted to study, who completed a questionnaire consisting of: scale of servant leadership, work ethic, GHQ-12 and brand love. By applying a quantitative method using a structural equation modeling partial least squares approach.

Results

The present study demonstrated that the three constructs (servant leadership, brand love, and work ethic) predict the general health of workers in a positive and significant way, in a sample of Peruvian workers in the education sector. Furthermore, the results suggest that these factors can be used to improve the health of employees in educational institutions in Peru and possibly in other contexts as well.

Conclusion

Given these results and after knowing the solidity of the predictions, the importance of promoting general health in workers in the education sector.
What are the roles of positive psychological construct in blended learning contexts? Integrating academic buoyancy into the Community of Inquiry framework
Authors: Yang Yan , Lay Yoon Fah
Published: April 2024

Introduction

In the post-epidemic era, blended learning has become a social trend for the future of higher education, and scholars have endeavored to understand the factors that influence student learning in these blended communities. Communities of Inquiry is a conceptual framework that describes the components of blended learning environments, indicating teaching presence, social presence, and cognitive presence. However, the framework fails to adequately explore how individual learning motivational factors influence student learning. Therefore, this study extends the Community of Inquiry framework by drawing on a positive psychological construct-academic buoyancy to reveal the relationship between academic buoyancy and the three presences through empirical research.

Methods

The theoretical model was validated by SPSS 26.0 and smartPLS4.0. To evaluate the measurement and structural models, structural equation modeling (SEM) was carried out using the partial least squares (PLS) method.

Findings

(a) Teaching presence positively predicts academic buoyancy, and academic buoyancy positively predicts social presence and cognitive presence; (b) academic buoyancy mediates teaching presence and social presence, as well as teaching presence and cognitive presence; and (c) academic buoyancy acts as a chain mediator between teaching presence and cognitive presence through social presence.

Discussion

The results of this study fill a gap in the multiple roles of individual positive psychological construct-academic buoyancy in blended learning communities, extend the Community of Inquiry theoretical framework, and provide empirical evidence for blended learning quality and practical improvement strategies.
Against the odds: exploring individuals’ pushback mechanisms against commercialized football gambling
Authors: Adebisi Tunde , Aregbesola Ayooluwa , Taiwo-Abdul Timilehin
Published: April 2024

Introduction

The need for money, the pursuit of pleasure, and the liberalized access to gambling have been documented in several pieces of literature as the drivers of gambling. Such drivers are predicated on commercialized gambling, leading to the growth of the gambling industry and constituting a structural influence that normalizes the activity among young people.

Methods

Through a qualitative inquiry, this study investigates the social agentic factors of individuals who are susceptible to gambling. Fifteen non-gamblers were recruited across three commercial cities in Africa, namely Nairobi, Lagos, and Johannesburg. We first established the gambling susceptibility of the participants: their need for money, their passion for football, ownership of a smartphone, access to the internet, and exposure to football gambling marketing.

Results

Consequently, we probed for their agency, which is indicative of why they do not gamble, despite being susceptible to engaging in the activity. Four major agentic factors were identified from the participants; knowledge of the industry’s business model, conserving the integrity of football, identity of self, morality and/or religion model.

Discussion

As such, these factors may be utilized to develop an intervention program for gamblers within the geographical context.
Cultural worldviews and waste sorting among urban Chinese dwellers: the mediating role of environmental risk perception
Authors: Cai Lin , Li Qingjun , Wan Erya , Luo Menglin , Tao Siwen
Published: April 2024

Objective

Waste sorting has received considerable attention in recent decades. However, research on the mechanisms underlying the relationships among cultural worldview, environmental risk perception, and waste sorting is rather scarce. This study aims to explore the cultural worldviews, environmental risk perception, and waste sorting among urban Chinese and their mechanisms.

Methods

This was a cross-sectional study involving 744 urban Chinese residents (371 men and 373 women). A questionnaire was utilized to measure cultural worldviews, environmental risk perception, and waste sorting. Pearson correlation analysis and structural equation modeling were used to examine the relationship between cultural worldviews, perceptions of environmental risk, and waste sorting.

Results

Waste sorting had a relatively insignificant negative relationship with fatalism and individualism. The correlation between environmental risk perception and cultural worldviews was negative except for egalitarianism, and the correlation between hierarchy and environmental risk perception was higher than the others, while individualism was higher than fatalism. Heightened environmental risk perception mediates the relationship between egalitarianism and waste sorting. Reduced environmental risk perception mediates the relationship between hierarchy and waste sorting, and mediates the relationship between individualism and waste sorting.

Conclusion

These new findings provide initial support for the mediating role of environmental risk perception in the relationship between cultural worldviews and waste sorting. Both theoretical and practical implications for understanding the psychological mechanisms of waste sorting are discussed.
Glossary of healthcare pathways: a methodological approach involving a transdisciplinary team in public health
Authors: Fraticelli Laurie , Verot Elise , Späth Hans-Martin , Genton Marine C. , Kempf Cédric , Clement Celine , Darlington-Bernard Adeline , Roy Sylvain , Dussart Claude , Mick Gérard , Carrouel Florence
Published: April 2024

Introduction

The healthcare pathway is at the heart of public health organization concerns, but communication between the various players can be an obstacle. This work, produced by a French transdisciplinary team, offers a methodological approach based on formalized consensus to elaborate a glossary of healthcare pathways. A two-steps procedure was elaborated, including a double rounded Delphi method to formalize expert consensus, and two groups of experts: a workgroup and a review group.

Methods

The workgroup provided a list of words or expressions that, in their opinion, described, evaluated or compared the healthcare pathways for patients, caregivers or regulators. The review group checked this list and added or deleted words or expressions. Then, definitions were added by the workgroup based into account three dimensions: official, academic and from the field. The review group validated the definitions and provided complementary proposals if needed.

Results

After pooling the list of words proposed by each of the six members of the working group, 417 words/expressions were ranked. After the two rounds of evaluation, 294 words/expressions were rated “appropriate” and were analyzed by the review group. This group, after two rounds of evaluation, agreed on 263 words/expressions that were transmitted to the working group who defined them. These definitions were rated by the review group. The first round of evaluation established 195 definitions as being appropriated whereas 68 definitions were amended by the review group.

Conclusion

This glossary supports transdisciplinary communication, reduces the extent of variations in practice and optimizes decision-making. International debate on all aspects might be strengthened by an improved understanding of the concept of health pathway.
Emergency department visits for dog bite injuries in Missouri municipalities with and without breed-specific legislation: a propensity score-matched analysis
Authors: Wyker Brett , Gupta Maya
Published: April 2024

Breed-Specific Legislation is a type of law that bans or restricts ownership of specific dog breeds. Some local governments – including over seventy municipalities in the state of Missouri – have enacted Breed-Specific Legislation to prevent injuries from dog bites. Several studies from the peer-reviewed literature have found that aggressive behavior is not associated with any particular dog breeds and, since 2018, at least a dozen municipalities in Missouri have repealed these laws. To evaluate the impact of Breed-Specific Legislation on public safety, the 2010–2015 rates of emergency department visits for dog bite-related injuries in Missouri municipalities with and without Breed-Specific Legislation were compared. Propensity-score matched negative binomial regression models were used to assess the effect of breed restrictions on injury rates while balancing the samples on population characteristics and estimates of dog ownership. After matching the sample on population, housing and dog ownership estimates, no association was found between emergency department visits for dog bite injuries and whether the municipality enacted Breed-Specific Legislation. However, the incidence rate ratio of emergency room visits for dog bite-related injuries increased by 13.8% for every 1% increase in the percentage of males aged 5 to 9 in the population (p < 0.01). This study has found breed discriminatory laws have not reduced the risk of emergency department visits for injury from dog bites in Missouri. There appears to be no greater risk to public safety as local governments move to repeal existing breed bans.
Association of depression and sleep quality with frailty: a cross-sectional study in China
Authors: Zhang Yue , Yu Ge , Bai Wei , Wu Songyu , Geng Xiaohan , Zhang Wangyi , Liu Yihang , Meng Yujiao , Gao Junling , Li Wenjun , Kou Changgui
Published: April 2024

Background

With the rapid growth of global aging, frailty has become a serious public health burden, affecting the life quality of older adults. Depressive symptoms (depression hereafter) and sleep quality are associated with frailty, but the pathways in which sleep quality and depression affect frailty remain unclear.

Method

This cross-sectional study included 1866 community-dwelling older adults. Demographic characteristics and health-related data of them was collected, and we also assessed frailty, depression, and sleep quality. Descriptive statistics were carried out and ordinal logistic regression analysis was used to identify the factors correlated with frailty. Spearman correlation analysis and mediation analysis were employed to assess associations between sleep quality, depression and frailty. Two-sided p < 0.05 was considered as significant.

Results

The results showed that 4.1% older adults were frail and 31.0% were pre-frail. Ordinal logistic regression showed that age, consumptions of vegetables, exercise, sleep quality, depression, number of chronic diseases, chronic pain, and self-rated health were correlated with frailty. Spearman correlation analysis revealed that frailty was associated with depression and sleep quality. There was a mediation effect that sleep quality was a significant and positive predictor of frailty (total effect = 0.0545, 95% boot CI = 0.0449–0.0641), and depression was a mediator between sleep quality and frailty (mediation effect = 60.4%).

Conclusion

Depression and poor sleep quality may be early indicators of frailty in older adults. Improving the sleep quality and psychological state of older adults can improve frailty, which is beneficial for healthy aging.
Socially-supported sleep in older adults aged 50 and older: a concept analysis
Authors: Huang Yingyan , Fleury Julie
Published: April 2024

Introduction

The population of older adults is growing disproportionately, constituting 13% of the global population in 2022, and is expected to double by 2050. One of public health’s priorities is healthy aging, the maintenance of functional ability aligned with well-being. As many as 50% of older adults report poor sleep quality, leading to an increased risk of morbidity and mortality. The quality and quantity of social relationships may broadly benefit sleep in older adults. However, the concept of socially-supported sleep is underdeveloped as a basis for intervention.

Methods

Existing literature was searched without time restriction in PubMed, CINAHL, PsycINFO, and Scopus ending in August 2022. Thematic analysis was used to determine the defining attributes, antecedents, and consequences of socially-supported sleep guided by Rodgers’ evolutionary concept analysis.

Results

Twenty-nine articles written in English, peer-reviewed, and examined social support and sleep in participants aged ≥50 were included. The defining attributes reflect dimensions of sleep quality. The antecedents are safe and secure, belonging and connection, and warmth and comfort. The consequences of socially-supported sleep include improved regulatory capabilities, physical and emotional well-being, and quality of life.

Conclusion

Socially-supported sleep has the potential to inform interventions that promote sleep in older adults. Ongoing research is needed to address the antecedents and mechanisms through which socially-supported sleep may promote sleep quality for healthy aging.
Impact of war-associated factors on spread of sexually transmitted infections: a systemic review
Authors: Kvasnevska Yulia , Faustova Mariia , Voronova Kseniia , Basarab Yaroslav , Lopatina Yaroslava
Published: April 2024

Introduction

Statistical data indicate a link between war and the spread of sexually transmitted infections (STIs), then it is necessary to carefully analyze the factors that directly affect the identified pattern in order to overcome this problem. Therefore, the purpose of the study was to systematically analyze the factors that influence the spread of STIs during war.

Methods

The study included all original research articles and meta-analyses on the impact of war on the spread of sexually transmitted infections that met the following eligibility criteria: (1) articles published exclusively in English; (2) articles published in the period 2013–2023; (3) studies with quantitative, qualitative or mixed design. The search for relevant literature was conducted using four databases: PubMed, Embase, Web of Science, and Ebsco.

Results

The articles selected for our systematic review had different research designs and were mainly published as original studies (n = 8) and literature reviews (n = 6). As a result of the evaluation of the selected articles for the systematic review, the authors identified migration, a decrease in access to health care, difficult access to contraception, sexual violence as the most frequent factors directly affecting the spread of STIs during the war.

Conclusion

This systematic review systematizes data on the impact of hostilities on the spread of STIs and outlines the main factors that contribute to the dissemination of pathogens far beyond the territory at the epicenter of the conflict.

Systematic review registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023479808, CRD42023479808.
Healthy lifestyle behaviors among teachers working in public primary schools and affecting factors
Authors: Örs Mukaddes
Published: April 2024

Healthy lifestyle behaviors have been recognized as a key strategy to achieve a policy of health for all. The aim of this study was to determine the levels of health promotion lifestyle behavior among teachers working in public primary schools. The present study also investigated the effects of selected socio-demographic characteristics on these behaviors. The research was designed using the survey model, one of the quantitative research methods. The sample of the research consisted of public primary school teachers (n = 372). Research data were collected using the Health-Promotion Lifestyle Profile-II (HPLP-II) scale. As a result of the research, it was put forward that there were statistically significant differences in levels of health promotion lifestyle behaviors based on taking courses on health promotion, and following programs and articles about healthy living (p < 0.05). It was revealed that primary teachers' taking courses on health promotion, and following programs and articles affected their healthy lifestyle behaviors. Public primary school teachers' health promotion lifestyle behaviors were found to be moderate. It was found that the primary teachers obtained the highest mean score for the spiritual growth subscale of the health promotion lifestyle behaviors scale; however, the primary school teachers had the lowest mean score for the physical activity subscale, which indicates that they need support in improving their healthy lifestyle. Male teachers had higher mean scores in the physical activity subscale, whereas females had higher mean scores in all other subscales. Training programs to protect and improve the health of teachers should be organized.
Enhancing research support services in health organizations by implementing a “Research Concierge Desk”, a case study
Authors: AlFattani Areej , AlFirm Abeer , AlBedah Norah , AlDakhil Haifa , Al Muaythir Elaf , Zeyad Leena , AlTwaijri Yasmin
Published: April 2024

Health organizations with teaching and research responsibilities face the need to establish a comprehensive system that addresses the processes and challenges associated with research activities; a system that assists local institutes in becoming research-active by identifying gaps and providing actionable recommendations. The involvement of epidemiologists, biostatisticians, and data scientists is paramount in offering technical and scientific support to health researchers. In our organization, research support services, such as technical, statistical, logistical, and scientific assistance, have been provided to researchers for the past 20 years under the name of “Data Clinic Service”. This article discusses the establishment of a physical booth called the “Research Concierge Desk” within a medical center to offer on-site, free-of-charge, and direct consultations to researchers, thereby improving accessibility to data clinic services. The underlying concept of the “Research Concierge Desk” is to align the research workflow for busy clinicians, who require vital assistance in the technical aspects of their research. As well, the desk and its digital platform enabled us to assess research process workflow, such as research submission, data clinic requests, research progress tracking, and researcher satisfaction assessment. We present the initiation of the “Research Concierge Desk” as an innovative solution in hospital settings, outline the available resources, benefits, challenges, and propose areas for improvement. The experience gained from implementing the “Research Concierge Desk” model can greatly benefit other health centers in adopting a similar approach to develop enhanced services for clinical researchers.
How to See It Both Ways
Authors: Zappe Ashley , Papesh Megan H.
Published: April 2024

When you see something, how do you figure out what it is? It might seem like you “just know”, but your brain uses two methods to help you know what you are seeing. One method is called bottom-up processing. In this method, the brain uses the shapes and colors seen by your eyes to figure out what something is. The other method is called top-down processing, which uses experiences, memories, or expectations to figure out what you are seeing. These processes happen at the same time in different parts of the brain. This article will explain how the brain’s top-down and bottom-up expectations can change what you see, and we include special pictures so you can experience it yourself.
Acute physiological, biomechanical, and perceptual responses of runners wearing downward-curved carbon fiber insoles
Authors: Engel Florian A. , Zehnter Frank , Yona Tomer , Mai Patrick , Willwacher Steffen , Düking Peter , Sperlich Billy
Published: April 2024

In a randomized controlled cross-over study ten male runners (26.7 ± 4.9 years; recent 5-km time: 18:37 ± 1:07 min:s) performed an incremental treadmill test (ITT) and a 3-km time trial (3-km TT) on a treadmill while wearing either carbon fiber insoles with downwards curvature or insoles made of butyl rubber (control condition) in light road racing shoes (Saucony Fastwitch 9). Oxygen uptake, respiratory exchange ratio, heart rate, blood lactate concentration, stride frequency, stride length and time to exhaustion were assessed during ITT. After ITT, all runners rated their perceived exertion, perceived shoe comfort and perceived shoe performance. Running time, heart rate, blood lactate levels, stride frequency and stride length were recorded during, and shoe comfort and shoe performance after, the 3-km TT. All parameters obtained during or after the ITT did not differ between the two conditions [range: p = 0.188 to 0.948 (alpha value: 0.05); Cohen's d = 0.021 to 0.479] despite the rating of shoe comfort showing better scores for the control insoles (p = 0.001; d = −1.646). All parameters during and after the 3-km TT showed no differences (p = 0.200 to 1.000; d = 0.000 to 0.501) between both conditions except for shoe comfort showing better scores for control insoles (p = 0.017; d = −0.919). Running with carbon fiber insoles with downwards curvature did not change running performance or any submaximal or maximal physiological or biomechanical parameter and perceived exertion compared to control condition. Shoe comfort is impaired while running with carbon fiber insoles. Wearing carbon fiber insoles with downwards curvature during treadmill running is not beneficial when compared to running with control insoles.
The associations of daily steps and body mass index with incident gastroesophageal reflux disease in older adults
Authors: Saavedra Joey M. , Lefferts Elizabeth C. , Song Bong Kil , Lee Duck-chul
Published: April 2024

Background

High body mass index (BMI) is a major risk factor of gastroesophageal reflux disease (GERD), a prevalent morbidity of older adulthood linked to lower quality of life and an increased risk of esophageal cancers. Daily stepping behavior, the most common physical activity of older adulthood, is associated with an array of favorable health outcomes, sometimes independent of high BMI. Whether stepping behavior is associated with the incidence of GERD independently or in combination with BMI is currently unclear.

Materials and methods

We followed 442 individuals (58.4% female) aged 65–91 years enrolled in the Physical Activity and Aging Study. Baseline steps were obtained by pedometer and categorized by tertiles (lower, middle, upper), while BMI was categorized into normal weight, overweight, and obesity. To explore joint associations, daily steps were dichotomized into “high steps” (middle/upper tertiles) and “low steps” (lower tertile), while BMI was dichotomized into normal weight and overweight/obesity. The joint exposure categories included “low steps and overweight/obesity,” “low steps and normal weight,” “high steps and overweight/obesity,” and “high steps and normal weight.”

Results

We identified 35 (7.9%) cases of GERD over a mean follow-up of 2.5 years. Compared to the lower tertile of steps, the hazard ratios (HRs) [95% confidence intervals (95% CIs)] of GERD were 0.44 (0.20–0.96) and 0.17 (0.05–0.54) for the middle and upper tertiles, respectively, after adjusting for confounders (including BMI). Compared to normal weight, the HRs (95% CIs) of GERD were 1.35 (0.54–3.37) and 3.00 (1.19–7.55) for overweight and obesity, respectively, after adjusting for confounders (including steps). In a joint analysis, compared to “low steps and overweight/obesity,” the HRs (95% CIs) of GERD were 0.32 (0.10–1.00), 0.23 (0.10–0.54), and 0.20 (0.07–0.58) for “low steps and normal weight,” “high steps and overweight/obesity,” and “high steps and normal weight,” respectively.

Conclusion

Higher daily steps were associated with a lower risk of GERD in older adults, independent of BMI. Since accumulating steps through walking is an achievable and acceptable modality of physical activity in older adulthood, future lifestyle interventions designed to achieve high daily steps counts may have favorable implications for the development of GERD in older adults of any BMI status.
Analyzing the impact of non-participation in the FIFA World Cup Qatar 2022 on LaLiga players' physical performance
Authors: Reverte-Pagola Gonzalo , Pecci Javier , del Ojo-López Juan José , del Campo Roberto López , Resta Ricardo , Feria-Madueño Adrián
Published: April 2024

Background

Monitoring external load demands in soccer is crucial for optimizing performance and reducing injury risk. However, events like the FIFA World Cup Qatar 2022 and unexpected interruptions can disrupt load management strategies. Understanding the impact of such events on player performance is essential for effective training and recovery strategies.

Objective

This study retrospectively assessed the impact of the FIFA World Cup Qatar 2022 on the physical performance of LaLiga elite soccer players who were not part of the tournament. The aim was to analyze various external load parameters and determine the direction of their changes post-tournament.

Methods

Data from 239 LaLiga players who were not selected for the World Cup were analyzed. External load parameters from 8 matches before and after the tournament were compared. Statistical analyses, including repeated measures ANOVA, were conducted to evaluate changes in performance metrics.

Results

Minutes played and total distance covered showed no significant changes post-tournament. However, maximal speed decreased significantly (p < 0.001; η2p = 0.117). High-speed running parameters improved significantly (p < 0.05), except for HSRRelCount (p = 0.074; η2p = 0.013). Sprint-related variables demonstrated significant enhancements, except for SprintAbsAvgDuration, SprintMaxAvgDuration, and Sprints >85% Vel Max. Acceleration metrics showed significant improvements in Accel_HighIntensityAccAbsCount (p = 0.024; η2p = 0.021), while Accel_Accelerations showed no significant changes. Deceleration metrics remained unchanged, but Accel_HighIntensityDecAbsCount and Accel_HighIntensityDecAbsDistance increased significantly post-tournament (p = 0.002; η2p = 0.040, p = 0.001; η2p = 0.044, respectively).

Conclusion

Non-participant LaLiga players demonstrated enhanced performance in most external load metrics after the FIFA World Cup Qatar 2022. These findings highlight the importance of effective load management during periods of competition interruption and suggest strategies to optimize performance and reduce injury risk. Further research should consider holistic performance metrics and internal load parameters to provide comprehensive insights into player response to mid-season tournaments.
Traditional African vegetables’ seed access and management practices: case of Vernonia amygdalina (Delile) in southern Benin
Authors: Houegban Jordan , Aglinglo Lys Amavi , N’Danikou Sognigbé , Tchokponhoué Dèdéou A. , Amissah Jacqueline Naalamle , Ankamah-Yeboah Theresa , Achigan-Dako Enoch
Published: April 2024

Vernonia amygdalina is an African traditional leafy vegetable which is a source of income for many households involved in its production in West and Central Africa. The species possesses several medicinal and nutritional properties. Despite its importance, there is limited information on farmers’ access to seed, seed production practices, seed trade, and related constraints. This research aimed at investigating farmers’ seed access and management practices. A non-probabilistic snowball method was used to sample and interview 164 bitter leaf seed sector actors from urban and peri-urban areas in Benin. Results indicated that vegetable farming is mainly practiced by men and it was the main occupation for 94.47% of the farmers interviewed. A significant association was found between the location and farmers’ experience (p-value = 0.01358). A diversity of Vernonia amygdalina morphotypes were found. Sixty-three percent of the farmers surveyed use seeds as planting material, 29% use purchased seedlings and only 7% use stem cuttings for Vernonia amygdalina production. Most of the seeds used (74%) were from farmer-saved seeds, harvested from isolated plants during production. The main constraints to V. amygdalina production reported by farmers were the unavailability of seeds (41% of respondents), low germination percentage (18%) and low seed longevity (12%). Findings from this study can inform solutions to improve farmers’ access to high-quality seeds and enhance V. amygdalina vegetable production.
Urban food waste for soil amendment? Analysis and characterisation of waste-based compost for soil fertility management in agroecological horticultural production systems in the city of Rosario, Argentina
Authors: Terrile R. , Martinez N. , Paz N. , Brunotto F. , Costa M. , Budai N. , Ruiz C. , Rizzi M. , Invernizzi M. , Scarpeci T. , Piacentini R. D. , Winter K. , Tornaghi C.
Published: April 2024

Urban and peri-urban lands can be an important source of food production for localised and sustainable food systems, however, their soils can be of poor quality, degraded or damaged by anthropic activities, and little is known about their suitability or safety. This paper aims to contribute to this knowledge gap by assessing the soil remediation capacity and qualities of different types of compost made from urban and peri-urban organic wastes for agroecological food production. Prepared over the course of 2021, and used in 2022 for food growing, five different composts were observed and analysed, in two different farms in the city of Rosario, Argentina. Four raw materials generated largely by local industries were used to make the composts: chicken manure, rumen (cow’s stomachs), brewer’s bagasse (byproducts of the beer industry) and urban leaves collected from the municipality waste collection. These were mixed in different proportions (all reaching the 20–30 C/N ratio, typical of quality compost) to produce viable growing substrates where radishes and lettuces were grown. The aim of the study was to assess the possibility, quality and limitations to use locally available organic inputs for soil fertility management in agroecological farming, in the context of urbanisation and to assess pathways to develop closed-cycle agroecological agriculture at metropolitan level. Natural manure substrates (raw and composted) were analysed, as well as crops grown and fertilised with each of the substrates. The attributes and limiting factors of each substrate and their response to local soil conditions were compared and physicochemical, biochemical, and microbiological analyses were performed, including among others, the study of microbial biomass, biological activity, biophytotoxicity, pH, aerobic heterotrophs, nitrogen fixation, and the presence of antibiotics, agrochemicals and heavy metals. The results of the analyses show that all the composted materials improved the physical, chemical and biological properties. However, in some cases, pollutants were present even after composting. Analysis carried out on the vegetables generally indicate undetectable levels or levels below the admissible limits, demonstrating the filtering capacity of the different composts and the soil.
Melanoma of the dog and cat: consensus and guidelines
Authors: Polton Gerry , Borrego Juan F. , Clemente-Vicario Francisco , Clifford Craig A. , Jagielski Dariusz , Kessler Martin , Kobayashi Tetsuya , Lanore Didier , Queiroga Felisbina L. , Rowe Annika Tranaeus , Vajdovich Péter , Bergman Philip J.
Published: April 2024

Melanoma of the dog and cat poses a clinical challenge to veterinary practitioners across the globe. As knowledge evolves, so too do clinical practices. However, there remain uncertainties and controversies. There is value for the veterinary community at large in the generation of a contemporary wide-ranging guideline document. The aim of this project was therefore to assimilate the available published knowledge into a single accessible referenced resource and to provide expert clinical guidance to support professional colleagues as they navigate current melanoma challenges and controversies. Melanocytic tumors are common in dogs but rare in cats. The history and clinical signs relate to the anatomic site of the melanoma. Oral and subungual malignant melanomas are the most common malignant types in dogs. While many melanocytic tumors are heavily pigmented, making diagnosis relatively straightforward, melanin pigmentation is variable. A validated clinical stage scheme has been defined for canine oral melanoma. For all other locations and for feline melanoma, TNM-based staging applies. Certain histological characteristics have been shown to bear prognostic significance and can thus prove instructive in clinical decision making. Surgical resection using wide margins is currently the mainstay of therapy for the local control of melanomas, regardless of primary location. Radiotherapy forms an integral part of the management of canine oral melanomas, both as a primary and an adjuvant therapy. Adjuvant immunotherapy or chemotherapy is offered to patients at high risk of developing distant metastasis. Location is the major prognostic factor, although it is not completely predictive of local invasiveness and metastatic potential. There are no specific guidelines regarding referral considerations for dogs with melanoma, as this is likely based on a multitude of factors. The ultimate goal is to provide the best options for patients to extend quality of life and survival, either within the primary care or referral hospital setting.
Identifying and addressing barriers and opportunities for bovine respiratory disease complex vaccination: a consensus paper on practical recommendations for best practise vaccination
Authors: Yarnall Matt , Amovilli Federica , Assié Sébastien , Bokma Jade , Pugh Matt , Werling Dirk
Published: April 2024

Many questions are raised, and challenges faced in the new era of (intranasal) bovine respiratory disease complex vaccination. An increase in vaccination rate is expected, due to its positive impact on cattle health, reduction of antimicrobial use and economic factors. However, engagement of farmers and veterinarians with regard to vaccination is often affected by limitations, resulting in the development of barriers to vaccination, but also opportunities to overcome these. The objective of the report is to provide practical recommendations and a consensus on best practises for BRDC vaccination, addressing barriers faced by veterinarians and farmers. The report combines an evidence review with expert opinions and includes discussions on different vaccination approaches, such as intranasal and systemic protocols. As result of the discussions, several barriers to BRDC vaccination were identified, including a lack of knowledge or visibility of the disease’s impact, the preference for blanket antibiotic use over vaccination, resistance to change, the need for visible success, uncertainty about the best time to vaccinate, and concerns about adverse reactions and vaccine efficacy in the presence of maternal antibodies. While these barriers seem substantial, they provide opportunities for the veterinary sector. Indeed, veterinarians are encouraged to use the argumentation presented, along with local case studies and diagnostic testing to highlight the impact of disease, while conducting calf health audits, ensuring expectations are managed to achieve visible success. Overall, this consensus paper aims to provide practical recommendations and support for veterinarians and farmers to overcome barriers and increase BRDC vaccination rates in cattle.