bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Figure 1 from Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia
Authors: Pillsbury Claire E. , Dougan Jodi , Rabe Jennifer L. , Fonseca Jairo A. , Zhou Chengjing , Evans Alyssa N. , Abukharma Hasan , Ichoku Ona , Gonzalez-Flamenco Gloria , Park Sunita I. , Aljudi Ahmed , DeRyckere Deborah , Castellino Sharon M. , Rafiq Sarwish , Langermann Solomon , Liu Linda N. , Henry Curtis J. , Porter Christopher C.
Published: July 2023

Pathological overexpression of Sig15 in leukemia.
FIGURE 6 from Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia
Authors: Pillsbury Claire E. , Dougan Jodi , Rabe Jennifer L. , Fonseca Jairo A. , Zhou Chengjing , Evans Alyssa N. , Abukharma Hasan , Ichoku Ona , Gonzalez-Flamenco Gloria , Park Sunita I. , Aljudi Ahmed , DeRyckere Deborah , Castellino Sharon M. , Rafiq Sarwish , Langermann Solomon , Liu Linda N. , Henry Curtis J. , Porter Christopher C.
Published: July 2023

Sig15 promotes an immunosuppressive tumor microenvironment in B-ALL. A–M, Unirradiated WT C57BL6 mice were injected via tail vein with 5 × 105 Cas9-only (n = 8 from two independent experiments) or Sig15 KO (n = 8) leukemia. Bone marrow was harvested 7 days later for highly dimensional flow cytometry of non-leukemia bone marrow populations. Healthy, leukemia-naïve mice (Naive) were included as controls (n = 6). CD3+ T cells (A), NK cells (B), classical dendritic cells (cDC; C), and neutrophils (D) were variably present at higher totals in the bone marrow of Sig15 KO recipient mice compared with control leukemia. E, Representative contour plots of T-cell populations. Proportions of CD8+ (F) but not CD4+ (G) T cells were higher in Sig15 KO recipients than control leukemia, increasing the CD8+/CD4+ T-cell ratio (H) to levels comparable with Naive mice. I, Degranulated CD8+ T cells were higher in Sig15 KO recipient mice, as were SLEC (J) and MPEC (K) CD8+ T-cell populations. Early memory-like populations consistent with central (L) and effector memory (M) CD8+ T-cell populations were also higher in Sig15 KO recipients. N–P, From the same experiments, bone marrow supernatant from control and Sig15 KO leukemia recipient mice was analyzed via 44-plex cytokine/chemokine assay. Levels of IL6 (N), LIF (O), and IL5 (P) were all significantly lower in the bone marrow of Sig15 KO recipients as compared with control leukemia (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001). Sig15 expression on B-ALL cells suppresses CD8+ T-cell expansion and activation and contributes overall to formation of a more proleukemia bone marrow microenvironment.
FIGURE 3 from Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia
Authors: Pillsbury Claire E. , Dougan Jodi , Rabe Jennifer L. , Fonseca Jairo A. , Zhou Chengjing , Evans Alyssa N. , Abukharma Hasan , Ichoku Ona , Gonzalez-Flamenco Gloria , Park Sunita I. , Aljudi Ahmed , DeRyckere Deborah , Castellino Sharon M. , Rafiq Sarwish , Langermann Solomon , Liu Linda N. , Henry Curtis J. , Porter Christopher C.
Published: July 2023

B-ALL–expressed Sig15 has dynamic subcellular localization. A, Flow cytometry of human B-ALL cell lines probed for SIG15 in both permeabilized and unpermeabilized (Surface) cells. Dotted line marks mean fluorescence intensity (MFI) of healthy PBMC signal (data representative of three independent experiments). Leukemia and PBMCs had modest surface expression of SIG15, while leukemia cells expressed higher intracellular SIG15 compared with PBMCs. SIG15 was probed using the NP159 mAb (NextCure). B and C, Immunofluorescence of REH cells staining for DAPI, Sig15, and Golgin-97. B, Imaging depicts limited surface localization of Sig15 and strong colocalization with the Golgi apparatus and TGN in unstimulated REH cells. C, Representative images depict REH cells treated for 24 hours with DMSO (vehicle control) or 81 nmol/L PMA and 1.3 μmol/L ionomycin. Stimulated REH cells show decreased colocalization of Sig15 signal with Golgin-97. SIG15 was probed using the Invitrogen polyclonal antibody. D, Flow cytometry of unpermeabilized REH cells treated with PMA with or without BOT64 for 6 hours, demonstrating that NFkB activation stimulates Sig15 localization at the cell surface (data representative of three independent experiments; dotted line represents MFI of isotype staining). SIG15 was probed using the NP159 mAb (NextCure) conjugated to Alexa Fluor 647.
Supplementary Table S5 from Cancer Epidemiology in the Northeastern United States (2013-2017)
Authors: Rees Judy R , Weiss Julie E , Gunn Christine M , Carlos Heather A , Dragnev Nathalie C , Supattapone Emma Y , Tosteson Anna N.A. , Kraft Sally A , Vahdat Linda T , Peacock Janet L
Published: July 2023

Comparison of Age-standardized Cancer Mortality*, All Races, for Maine, New Hampshire, Vermont with the United States, 2013–2017
Supplementary Table 4 from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer
Authors: Moutafi Myrto , Koliou Georgia-Angeliki , Papaxoinis George , Economopoulou Panagiota , Kotsantis Ioannis , Gkotzamanidou Maria , Anastasiou Maria , Pectasides Dimitrios , Kyrodimos Efthymios , Delides Alexander , Giotakis Evangelos , Papadimitriou Nikolaos G. , Panayiotides Ioannis G. , Perisanidis Christos , Fernandez Aileen I. , Xirou Vasiliki , Poulios Christos , Gagari Eleni , Yaghoobi Vesal , Gavrielatou Niki , Shafi Saba , Aung Thazin Nwe , Kougioumtzopoulou Andromachi , Kouloulias Vassilis , Palialexis Konstantinos , Gkolfinopoulos Stavros , Strati Areti , Lianidou Evi , Fountzilas George , Rimm David L. , Foukas Periklis G. , Psyrri Amanda
Published: July 2023

Table 4a. Fold-change values for each signature between Response and No Response based on physical examination, pathology or imaging
Table 4b. Fold-change values for significantly differentially expressed genes between Response and No Response based on physical examination, pathology or imaging
Supplementary Table 3 from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer
Authors: Moutafi Myrto , Koliou Georgia-Angeliki , Papaxoinis George , Economopoulou Panagiota , Kotsantis Ioannis , Gkotzamanidou Maria , Anastasiou Maria , Pectasides Dimitrios , Kyrodimos Efthymios , Delides Alexander , Giotakis Evangelos , Papadimitriou Nikolaos G. , Panayiotides Ioannis G. , Perisanidis Christos , Fernandez Aileen I. , Xirou Vasiliki , Poulios Christos , Gagari Eleni , Yaghoobi Vesal , Gavrielatou Niki , Shafi Saba , Aung Thazin Nwe , Kougioumtzopoulou Andromachi , Kouloulias Vassilis , Palialexis Konstantinos , Gkolfinopoulos Stavros , Strati Areti , Lianidou Evi , Fountzilas George , Rimm David L. , Foukas Periklis G. , Psyrri Amanda
Published: July 2023

Supplementary Table 3. Genes with significanlty changes pre- and post-Olaparib based treatment
Supplementary Table 2 from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer
Authors: Moutafi Myrto , Koliou Georgia-Angeliki , Papaxoinis George , Economopoulou Panagiota , Kotsantis Ioannis , Gkotzamanidou Maria , Anastasiou Maria , Pectasides Dimitrios , Kyrodimos Efthymios , Delides Alexander , Giotakis Evangelos , Papadimitriou Nikolaos G. , Panayiotides Ioannis G. , Perisanidis Christos , Fernandez Aileen I. , Xirou Vasiliki , Poulios Christos , Gagari Eleni , Yaghoobi Vesal , Gavrielatou Niki , Shafi Saba , Aung Thazin Nwe , Kougioumtzopoulou Andromachi , Kouloulias Vassilis , Palialexis Konstantinos , Gkolfinopoulos Stavros , Strati Areti , Lianidou Evi , Fountzilas George , Rimm David L. , Foukas Periklis G. , Psyrri Amanda
Published: July 2023

Supplementary Table 2. Signature scores with significanlty changes pre- and post-Olaparib based treatment
Supplementary Table S2 from Cancer Epidemiology in the Northeastern United States (2013-2017)
Authors: Rees Judy R , Weiss Julie E , Gunn Christine M , Carlos Heather A , Dragnev Nathalie C , Supattapone Emma Y , Tosteson Anna N.A. , Kraft Sally A , Vahdat Linda T , Peacock Janet L
Published: July 2023

Comparison of Age-standardized Incidence of Leading Cancer Sites, All Races, for Maine, New Hampshire, Vermont with United States 2013–2017
Supplementary Materials and Methods from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer
Authors: Moutafi Myrto , Koliou Georgia-Angeliki , Papaxoinis George , Economopoulou Panagiota , Kotsantis Ioannis , Gkotzamanidou Maria , Anastasiou Maria , Pectasides Dimitrios , Kyrodimos Efthymios , Delides Alexander , Giotakis Evangelos , Papadimitriou Nikolaos G. , Panayiotides Ioannis G. , Perisanidis Christos , Fernandez Aileen I. , Xirou Vasiliki , Poulios Christos , Gagari Eleni , Yaghoobi Vesal , Gavrielatou Niki , Shafi Saba , Aung Thazin Nwe , Kougioumtzopoulou Andromachi , Kouloulias Vassilis , Palialexis Konstantinos , Gkolfinopoulos Stavros , Strati Areti , Lianidou Evi , Fountzilas George , Rimm David L. , Foukas Periklis G. , Psyrri Amanda
Published: July 2023

The details for the assays and image analysis are summarized in the Supplementary Materials and Methods.
Supplementary Figure 2 from Cancer Epidemiology in the Northeastern United States (2013-2017)
Authors: Rees Judy R , Weiss Julie E , Gunn Christine M , Carlos Heather A , Dragnev Nathalie C , Supattapone Emma Y , Tosteson Anna N.A. , Kraft Sally A , Vahdat Linda T , Peacock Janet L
Published: July 2023

Average Annual Percent Change (APC) in Age-Adjusted Cancer Incidence (2014-2018); Figure 2b Average Annual Percent Change (APC) in Age-Adjusted Cancer Mortality (2014-18)
Supplementary Figure 4 from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer
Authors: Moutafi Myrto , Koliou Georgia-Angeliki , Papaxoinis George , Economopoulou Panagiota , Kotsantis Ioannis , Gkotzamanidou Maria , Anastasiou Maria , Pectasides Dimitrios , Kyrodimos Efthymios , Delides Alexander , Giotakis Evangelos , Papadimitriou Nikolaos G. , Panayiotides Ioannis G. , Perisanidis Christos , Fernandez Aileen I. , Xirou Vasiliki , Poulios Christos , Gagari Eleni , Yaghoobi Vesal , Gavrielatou Niki , Shafi Saba , Aung Thazin Nwe , Kougioumtzopoulou Andromachi , Kouloulias Vassilis , Palialexis Konstantinos , Gkolfinopoulos Stavros , Strati Areti , Lianidou Evi , Fountzilas George , Rimm David L. , Foukas Periklis G. , Psyrri Amanda
Published: July 2023

Supplementary Figure 4. Relative fold change (2-ΔΔCq) of PD-L1 in respect to Β2Μ (reference gene) in the CTC fraction for individual samples of HNSCC patients before (blue) and after (orange) therapy.
Supplementary Figure 3 from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer
Authors: Moutafi Myrto , Koliou Georgia-Angeliki , Papaxoinis George , Economopoulou Panagiota , Kotsantis Ioannis , Gkotzamanidou Maria , Anastasiou Maria , Pectasides Dimitrios , Kyrodimos Efthymios , Delides Alexander , Giotakis Evangelos , Papadimitriou Nikolaos G. , Panayiotides Ioannis G. , Perisanidis Christos , Fernandez Aileen I. , Xirou Vasiliki , Poulios Christos , Gagari Eleni , Yaghoobi Vesal , Gavrielatou Niki , Shafi Saba , Aung Thazin Nwe , Kougioumtzopoulou Andromachi , Kouloulias Vassilis , Palialexis Konstantinos , Gkolfinopoulos Stavros , Strati Areti , Lianidou Evi , Fountzilas George , Rimm David L. , Foukas Periklis G. , Psyrri Amanda
Published: July 2023

Supplementary Figure 3. A. No significant differences in stromal TILs were found between pre- and post-treatment samples in all arms. In Arm D TILs were increased post-treatment in most of the samples (5 out of 7). Figures B and C show representative images of TILs in pre- and post-treatment samples respectively from one patient in Arm D, measured by QuPath v0.3.0. Figures show tissues before (left) and after (right) QuPath annotations. Color legend; red, tumor cells; purple, lymphocytes; green, fibroblasts; yellow, other; Cisplatin-Olaparib, C-O; Olaparib, O; Durvalumab-Olaparib, D-O
Supplementary Video 1B from Targeted single cell isolation of spontaneously escaping live melanoma cells for comparative transcriptomics
Authors: Tearle Jacqueline L. E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Supplementary Video 1B shows representative images of a naltrindole-treated spheroid. Scale bar: 200 µm, number at top left: days post-implantation.
Supplementary Video 1A from Targeted single cell isolation of spontaneously escaping live melanoma cells for comparative transcriptomics
Authors: Tearle Jacqueline L. E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Supplementary Video 1A shows representative daily images of a vehicle-treated spheroid. Scale bar: 200 µm, number at top left: days post-implantation.
Supplementary Figure 1 from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer
Authors: Moutafi Myrto , Koliou Georgia-Angeliki , Papaxoinis George , Economopoulou Panagiota , Kotsantis Ioannis , Gkotzamanidou Maria , Anastasiou Maria , Pectasides Dimitrios , Kyrodimos Efthymios , Delides Alexander , Giotakis Evangelos , Papadimitriou Nikolaos G. , Panayiotides Ioannis G. , Perisanidis Christos , Fernandez Aileen I. , Xirou Vasiliki , Poulios Christos , Gagari Eleni , Yaghoobi Vesal , Gavrielatou Niki , Shafi Saba , Aung Thazin Nwe , Kougioumtzopoulou Andromachi , Kouloulias Vassilis , Palialexis Konstantinos , Gkolfinopoulos Stavros , Strati Areti , Lianidou Evi , Fountzilas George , Rimm David L. , Foukas Periklis G. , Psyrri Amanda
Published: July 2023

Supplementary Figure 1. Differentially expressed genes (Left) and gene signatures (Right) Cisplatin-Olaparib (A, B), Olaparib (C,D) and Durvalumab-Olaparib (E, F) arms in pre- and post-treatment samples. The significance (p-value, P and adjusted p-value, Padj) is represented relative to Fold Change (FC) in the x-axis.
Supplementary Table 5 from Targeted single cell isolation of spontaneously escaping live melanoma cells for comparative transcriptomics
Authors: Tearle Jacqueline L. E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Supplementary Table 5 shows Differentially expressed genes for epithelial vs. amoeboid analysis
Supplementary Table 3 from Targeted single cell isolation of spontaneously escaping live melanoma cells for comparative transcriptomics
Authors: Tearle Jacqueline L. E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Supplementary Table 3 shows Differentially expressed genes for escaping vs. epithelial analysis
Supplementary Table 1 from Targeted single cell isolation of spontaneously escaping live melanoma cells for comparative transcriptomics
Authors: Tearle Jacqueline L. E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Supplementary Table 1 shows Cell type isolated, age (days) and number of cells sorted for each spheroid included in the study
Supplementary Figure 7 from Targeted single cell isolation of spontaneously escaping live melanoma cells for comparative transcriptomics
Authors: Tearle Jacqueline L. E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Supplementary Figure 7 shows metadata for isolated cells
Supplementary Figure 3 from Targeted single cell isolation of spontaneously escaping live melanoma cells for comparative transcriptomics
Authors: Tearle Jacqueline L. E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Supplementary Figure 3 shows validation of OPRD1 and SLC19A1 protein expression
Data from Targeted Single-cell Isolation of Spontaneously Escaping Live Melanoma Cells for Comparative Transcriptomics
Authors: Tearle Jacqueline L.E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Solid cancer cells escape the primary tumor mass by transitioning from an epithelial-like state to an invasive migratory state. As they escape, metastatic cancer cells employ interchangeable modes of invasion, transitioning between fibroblast-like mesenchymal movement to amoeboid migration, where cells display a rounded morphology and navigate the extracellular matrix in a protease-independent manner. However, the gene transcripts that orchestrate the switch between epithelial, mesenchymal, and amoeboid states remain incompletely mapped, mainly due to a lack of methodologies that allow the direct comparison of the transcriptomes of spontaneously invasive cancer cells in distinct migratory states. Here, we report a novel single-cell isolation technique that provides detailed three-dimensional data on melanoma growth and invasion, and enables the isolation of live, spontaneously invasive cancer cells with distinct morphologies and invasion parameters. Via the expression of a photoconvertible fluorescent protein, compact epithelial-like cells at the periphery of a melanoma mass, elongated cells in the process of leaving the mass, and rounded amoeboid cells invading away from the mass were tagged, isolated, and subjected to single-cell RNA sequencing. A total of 462 differentially expressed genes were identified, from which two candidate proteins were selected for further pharmacologic perturbation, yielding striking effects on tumor escape and invasion, in line with the predictions from the transcriptomics data. This work describes a novel, adaptable, and readily implementable method for the analysis of the earliest phases of tumor escape and metastasis, and its application to the identification of genes underpinning the invasiveness of malignant melanoma.
Significance:
This work describes a readily implementable method that allows for the isolation of individual live tumor cells of interest for downstream analyses, and provides the single-cell transcriptomes of melanoma cells at distinct invasive states, both of which open avenues for in-depth investigations into the transcriptional regulation of the earliest phases of metastasis.
Data from Targeted single cell isolation of spontaneously escaping live melanoma cells for comparative transcriptomics
Authors: Tearle Jacqueline L. E. , Arjunan Satya N.V. , Tay Szun S. , Colakoglu Feyza , Cremasco James , Golo Matteo , Biro Maté
Published: July 2023

Abstract
Solid cancer cells escape the primary tumour mass by transitioning from an epithelial-like state to an invasive migratory state. As they escape, metastatic cancer cells employ interchangeable modes of invasion, transitioning between fibroblast-like mesenchymal movement to amoeboid migration, where cells display a rounded morphology and navigate the extracellular matrix in a protease-independent manner. However, the gene transcripts that orchestrate the switch between epithelial, mesenchymal and amoeboid states remain incompletely mapped, mainly due to a lack of methodologies that allow the direct comparison of the transcriptomes of spontaneously invasive cancer cells in distinct migratory states. Here, we report a novel single cell isolation technique that provides detailed 3D data on melanoma growth and invasion, and enables the isolation of live, spontaneously invasive cancer cells with distinct morphologies and invasion parameters. Via the expression of a photoconvertible fluorescent protein, compact epithelial-like cells at the periphery of a melanoma mass, elongated cells in the process of leaving the mass, and rounded amoeboid cells invading away from the mass were tagged, isolated and subjected to single cell RNA-sequencing. 462 differentially expressed genes were identified, from which two candidate proteins were selected for further pharmacological perturbation, yielding striking effects on tumour escape and invasion, in line with the predictions from the transcriptomics data. This work describes a novel, adaptable and readily implementable method for the analysis of the earliest phases of tumour escape and metastasis, and its application to the identification of genes underpinning the invasiveness of malignant melanoma.
Os descolamentos do sentido, os sentidos do deslocamento: Vera Lúcia Gonçalves Felício
Authors: Pereira Marinê
Published: July 2023

O texto procura realizar uma apresentação do “percurso-pensamento” de Vera Lúcia Gonçalves Felício, professora do Departamento de Filosofia da USP por cerca de vinte anos, a partir de seus escritos, que foram publicados ao longo de décadas em diferentes meios, tais como livros, revistas e jornais.
Na companhia de Hilda Hilst, Mira Schendel e Amélia Toledo
Authors: Cacciola Maria Lúcia
Published: July 2023

O texto a seguir foi apresentado no II Encontro do Grupo de Trabalho de Filosofia e Gênero da ANPOF, na USP, entre os dias 4 e 6 de setembro de 2019, e trata-se de um depoimento de Maria Lúcia Cacciolla.
Race-Based Differences in ST-Segment–Elevation Myocardial Infarction Process Metrics and Mortality From 2015 Through 2021: An Analysis of 178 062 Patients From the American Heart Association Get With The Guidelines–Coronary Artery Disease Registry
Authors: Osho Asishana , Fernandes Marcelo F. , Poudel Ram , de Lemos James , Hong Haoyun , Zhao Juan , Li Shen , Thomas Kathie , Kikuchi Daniel S. , Zegre-Hemsey Jessica , Ibrahim Nasrien , Shah Nilay S. , Hollowell Lori , Tamis-Holland Jacqueline , Granger Christopher B. , Cohen Mauricio , Henry Timothy , Jacobs Alice K. , Jollis James G. , Yancy Clyde W. , Goyal Abhinav
Published: July 2023

BACKGROUND:

Systems of care have been developed across the United States to standardize care processes and improve outcomes in patients with ST-segment–elevation myocardial infarction (STEMI). The effect of contemporary STEMI systems of care on racial and ethnic disparities in achievement of time-to-treatment goals and mortality in STEMI is uncertain.

METHODS:

We analyzed 178 062 patients with STEMI (52 293 women and 125 769 men) enrolled in the American Heart Association Get With The Guidelines–Coronary Artery Disease registry between January 1, 2015, and December 31, 2021. Patients were stratified into and outcomes compared among 3 racial and ethnic groups: non-Hispanic White, Hispanic White, and Black. The primary outcomes were the proportions of patients achieving the following STEMI process metrics: prehospital ECG obtained by emergency medical services; hospital arrival to ECG obtained within 10 minutes for patients not transported by emergency medical services; arrival-to–percutaneous coronary intervention time within 90 minutes; and first medical contact–to-device time within 90 minutes. A secondary outcome was in-hospital mortality. Analyses were performed separately in women and men, and all outcomes were adjusted for age, comorbidities, acuity of presentation, insurance status, and socioeconomic status measured by social vulnerability index based on patients’ county of residence.

RESULTS:

Compared with non-Hispanic White patients with STEMI, Hispanic White patients and Black patients had lower odds of receiving a prehospital ECG and achieving targets for door-to-ECG, door-to-device, and first medical contact–to-device times. These racial disparities in treatment goals were observed in both women and men, and persisted in most cases after multivariable adjustment. Compared with non-Hispanic White women, Hispanic White women had higher adjusted in-hospital mortality (odds ratio, 1.39 [95% CI, 1.12–1.72]), whereas Black women did not (odds ratio, 0.88 [95% CI, 0.74–1.03]). Compared with non-Hispanic White men, adjusted in-hospital mortality was similar in Hispanic White men (odds ratio, 0.99 [95% CI, 0.82–1.18]) and Black men (odds ratio, 0.96 [95% CI, 0.85–1.09]).

CONCLUSIONS:

Race- or ethnicity-based disparities persist in STEMI process metrics in both women and men, and mortality differences are observed in Hispanic White compared with non-Hispanic White women. Further research is essential to evolve systems of care to mitigate racial differences in STEMI outcomes.
Decadal Change in the Linkage between QBO and the Leading Mode of Southeast China Winter Precipitation
Authors: Zhang Ruhua , Zhou Wen
Published: July 2023

In this study, observational and model datasets are used to analyze winter precipitation and its leading empirical orthogonal function (EOF1) mode over Southeast China. EOF1 displays a dominant monosign pattern during the last 60 years; however, its major impacting factors have a decadal transition near the mid-1990s. The first principal component (PC1) is related to El Niño–Southern Oscillation (ENSO) after the mid-1990s and to the quasi-biennial oscillation (QBO) before the mid-1990s. An enhanced ENSO–precipitation relationship is associated with stronger ENSO-induced tropical zonal circulation and the westward shift of ENSO-induced SST over the tropical Pacific after the mid-1990s compared to before the mid-1990s. Negative correlation coefficients between QBO and precipitation are evident before the mid-1990s but are no longer statistically significant after the mid-1990s. This change originates from the interaction between QBO’s subtropical influences and the Holton–Tan effect. The QBO’s subtropical influence and the Holton–Tan effect lead to a zonal pressure gradient and meridional wind anomalies over East Asia before the mid-1990s, which further influence the meridional transport of water vapor and precipitation over Southeast China. However, the Holton–Tan effect is enhanced after the mid-1990s. Downward stratospheric polar vortex signals and the QBO’s subtropical influence cause a meridional pressure gradient over East Asia, and thus the relevant moisture flux divergence lacks statistical significance. The above results indicate that the subtropical response to QBO and the Holton–Tan effect should be considered together when using the QBO signal to improve forecasts of winter precipitation over East Asia.

Significance Statement

Southeast China winter precipitation (SCWP) is often attributed to variation in lower-atmospheric dynamics and sea surface temperature, such as El Niño–Southern Oscillation (ENSO). Few studies focus on the role of the mid- to upper atmosphere. In this study, we diagnose the influence of the stratospheric quasi-biennial oscillation (QBO) on SCWP. Both observational and modeling analyses indicate a strong decadal change in the QBO–SCWP relationship, which limits the use of the QBO in seasonal forecasts of SCWP. This decadal change originates from the strength of the QBO’s modulation of the stratospheric polar vortex. Our results provide a new perspective on the use of the mid- to upper atmosphere in seasonal forecasts of SCWP.
Improving Recidivism Forecasting With a Relaxed Naïve Bayes Classifier
Authors: Lee YongJei , O SooHyun , Eck John E.
Published: July 2023

Correctional authorities require accurate, unbiased, and interpretable tools to predict individuals’ chances of recidivating if released into the community. However, existing prediction models have serious limitations meeting these requirements. We overcome these limitations by applying an established medical diagnostic approach: a relaxed naïve Bayes classifier. Using logistic regression in the form of a naïve Bayes classifier, we estimate the weights of observed features of offenders on recidivism. We apply these weights in a relaxed naïve Bayes classifier to predict the probability of recidivism. Results show that acquired features are stronger predictors of recidivism than innate features. Relaxed naïve Bayes classifier produces far less racial disparity than most alternatives. Critically, it is easier for users to interpret than its alternatives.
Development and Validation of the System Trustworthiness Scale
Authors: Alarcon Gene M. , Capiola August , Lee Michael A. , Willis Sasha , Hamdan Izz Aldin , Jessup Sarah A. , Harris Krista N.
Published: July 2023

Objective

We created and validated a scale to measure perceptions of system trustworthiness.

Background

Several scales exist in the literature that attempt to assess trustworthiness of system referents. However, existing measures suffer from limitations in their development and validation. The current study sought to develop a scale based on theory and methodological rigor.

Method

We conducted exploratory and confirmatory factor analyses on data from two online studies to develop the System Trustworthiness Scale (STS). Additional analyses explored the manipulation of the factors and assessed convergent and divergent validity.

Results

The exploratory factor analyses resulted in a three-factor solution that represented the theoretical constructs of trustworthiness: performance, purpose, and process. Confirmatory factor analyses confirmed the three-factor solution. In addition, correlation and regression analyses demonstrated the scale’s divergent and predictive validity.

Conclusion

The STS is a psychometrically valid and predictive scale for assessing trustworthiness perceptions of system referents.

Applications

The STS assesses trustworthiness perceptions of systems. Importantly, the scale differentiates performance, purpose, and process constructs and is adaptable to a variety of system referents.
How Do Unsustainable Practices Remain Dominant? A Practice Theory Reinterpretation of Gramsci
Authors: Scheurenbrand Klara , Schatzki Theodore , Parsons Elizabeth , Patterson Anthony
Published: July 2023

Sociological studies of sustainable transformation have highlighted the relevance of ‘unequal’ and ‘uneven’ transformation dynamics. We argue that a practice-based approach provides far more insight into such unequal dynamics than currently recognized. We re-interpret the political concepts of agonism, antagonism and historic bloc that Gramsci used to analyse domination in order to theorize practice constellations and dynamics that are responsible for the perpetuation of unsustainable practices and the suppression of sustainable ones. Based on empirical findings, we also expand his vocabulary by introducing the concept of synergy. Using the example of urban cycling in Las Palmas de Gran Canaria, we propose a Gramscian-inspired account of power and domination in practices as a way of understanding inequality in transformation efforts.
Within-School Achievement Sorting in Comprehensive and Tracked Systems
Authors: Engzell Per , Raabe Isabel J.
Published: July 2023

Why do inequalities in schooling persist, even in relatively egalitarian school systems? This article examines within school sorting as an explanation. We use classroom data on friendship networks in 480 European secondary schools and contrast comprehensive (England, Sweden) and tracked systems (Germany, Netherlands). Our question is to what extent comprehensive systems reduce achievement sorting at the level of (a) schools, (b) classrooms, and (c) friendships. Between-school variance in achievement is lower in comprehensive systems. However, this is counterbalanced by greater sorting within schools, between classrooms, and, especially, in friendship networks. Still, comprehensive schools create more equal environments for two reasons. First, the difference in between school sorting is larger than the difference in within school sorting. Second, within school sorting is less strongly related to social background characteristics. These findings help explain both why comprehensive schools produce more equal outcomes and how substantial inequality can nevertheless persist.
The Reciprocal Relationship Between Awe and Perceived Stress Among Chinese Early Adolescents: A Cross-Lagged Analysis
Authors: Wang Jing , Huo Yongquan , Liu Jia
Published: July 2023

Stress among adolescents is a growing concern due to its adverse effects on health and social functioning, especially in China. Awe is related to relief of daily stress and reduction of stress-related symptoms. However, existing research related to perceived stress in Chinese adolescents has not considered awe; moreover, the possible influence of perceived stress on the tendency to feel awe is poorly understood. This study used two-wave cross-lagged analysis to explore the relationship between awe and perceived stress among Chinese adolescents. Three hundred and fifty Chinese middle school students aged 13 to 16 completed the Dispositional Awe Scale and Perceived Stress Scale questionnaires twice, with 3 months between responses. Results show that awe predicts lower levels of perceived stress over time, and perceived stress predicts lower levels of awe, supporting the idea of a reciprocal relationship between the two. This suggests potential practical interventions for stress management in Chinese adolescents.
You Accepted What?: The Impact of Location, Education, and Negotiation on Technical Communication Graduates’ Salaries
Authors: Seawright Leslie , Stanton Rhonda
Published: July 2023

In the discipline of technical/professional writing and communication, one of the strongest recruiting tools we use is the potential earning power students will have once they obtain a degree and secure a job in the industry. This article is the result of two professors learning that one of their most advanced and dedicated students accepted, in her first job out of graduate school, a salary we thought was thousands below her earning potential. Our conversations around this student's situation led us to survey other alumni from our programs. What we have learned is that students often do not know what salaries they should expect, nor do they feel comfortable negotiating a salary offer. In addition, graduates’ location (urban vs. rural) and level of education (BA or BS degree vs. MA) impact their earning potential.
Choosing an Optimal Method for Causal Decomposition Analysis with Continuous Outcomes: A Review and Simulation Study
Authors: Park Soojin , Kang Suyeon , Lee Chioun
Published: July 2023

Causal decomposition analysis is among the rapidly growing number of tools for identifying factors (“mediators”) that contribute to disparities in outcomes between social groups. An example of such mediators is college completion, which explains later health disparities between Black women and White men. The goal is to quantify how much a disparity would be reduced (or remain) if we hypothetically intervened to set the mediator distribution equal across social groups. Despite increasing interest in estimating disparity reduction and the disparity that remains, various estimation procedures are not straightforward, and researchers have scant guidance for choosing an optimal method. In this article, the authors evaluate the performance in terms of bias, variance, and coverage of three approaches that use different modeling strategies: (1) regression-based methods that impose restrictive modeling assumptions (e.g., linearity) and (2) weighting-based and (3) imputation-based methods that rely on the observed distribution of variables. The authors find a trade-off between the modeling assumptions required in the method and its performance. In terms of performance, regression-based methods operate best as long as the restrictive assumption of linearity is met. Methods relying on mediator models without imposing any modeling assumptions are sensitive to the ratio of the group-mediator association to the mediator-outcome association. These results highlight the importance of selecting an appropriate estimation procedure considering the data at hand.
Evaluating the Evidence for Enclothed Cognition: Z-Curve and Meta-Analyses
Authors: Horton C. Blaine , Adam Hajo , Galinsky Adam D.
Published: July 2023

Enclothed cognition refers to the systematic influence that clothes can have on the wearer’s feelings, thoughts, and behaviors through their symbolic meaning. It has attracted considerable academic and nonacademic interest, with the 2012 article that coined the phrase cited more than 600 times and covered in more than 160 news outlets. However, a recent high-powered replication failed to replicate one of the original effects. To determine whether the larger body of research on enclothed cognition possesses evidential value and replicable effects, we performed z-curve and meta-analyses using 105 effects from 40 studies across 24 articles ( N = 3,789). Underscoring the marked improvement of psychological research practices in the mid-2010s, our results raise concerns about the replicability of early enclothed cognition studies but affirm the evidential value for effects published after 2015. These later studies support the core principle of enclothed cognition—what we wear influences how we think, feel, and act.
Exploring sex differences for acute ischemic stroke clinical, imaging and thrombus characteristics in the INTERRSeCT study
Authors: Rebchuk Alexander D , Hill Michael D , Goyal Mayank , Demchuk Andrew , Coutts Shelagh B , Asdaghi Negar , Dowlatshahi Dar , Holodinsky Jessalyn K , Fainardi Enrico , Shankar Jai , Najm Mohamed , Rubiera Marta , Khaw Alexander V , Qiu Wu , Menon Bijoy K , Field Thalia S
Published: July 2023

Women, especially following menopause, are known to have worse outcomes following acute ischemic stroke. One primary postulated biological mechanism for worse outcomes in older women is a reduction in the vasculoprotective effects of estrogen. Using the INTERRseCT cohort, a multicentre international observational cohort studying recanalization in acute ischemic stroke, we explored the effects of sex, and modifying effects of age, on neuroradiological predictors of recanalization including robustness of leptomeningeal collaterals, thrombus burden and thrombus permeability. Ordinal regression analyses were used to examine the relationship between sex and each of the neuroradiological markers. Further, we explored both multiplicative and additive interactions between age and sex. All patients (n = 575) from INTERRseCT were included. Mean age was 70.2 years (SD: 13.1) and 48.5% were women. In the unadjusted model, female sex was associated with better collaterals (OR 1.37, 95% CIs: 1.01–1.85), however this relationship was not significant after adjusting for age and relevant comorbidities. There were no significant interactions between age and sex. In a large prospective international cohort, we found no association between sex and radiological predictors of recanalization including leptomeningeal collaterals, thrombus permeability and thrombus burden.
Local Control, Discretion, and Administrative Burden: SNAP Interview Waivers and Caseloads During the COVID-19 Pandemic
Authors: Heflin Colleen , Fannin William Clay , Lopoo Leonard
Published: July 2023

During the COVID-19 pandemic, the U.S. Department of Agriculture waived the certification interview for the Supplemental Nutritional Assistance Program (SNAP), substantially reducing the administrative burden associated with SNAP application for both applicants and agencies. Using primary policy data collected from ten county-administered states, we find that only 27% of counties implemented the interview waiver. Further, models of local decision-making indicate that public health risk, demographic vulnerability and economic need, and political orientation in the county were not statistically significant predictors of waiver use. Finally, we find that the waiver choice did affect SNAP caseloads: using difference-in-difference models that make use of the natural experiment, we find that counties that adopted the SNAP interview waivers experienced a 5% increase in SNAP caseloads.
California sea lion (Zalophus californianus) lymph-node explant reveals involvement and possible transcriptional regulation of SLAM and nectin-4 during phocine distemper virus infection
Authors: Gonzales-Viera Omar , Goldstein Tracey , Duignan Pádraig , Eiamcharoen Piyaporn , Keel M. Kevin
Published: July 2023

Phocine distemper virus (PDV) is a significant cause of mortality for phocid seals; however, the susceptibility of otariids to this virus is poorly understood. The authors used a lymph-node explant culture system from California sea lions ( Zalophus californianus, CSL) to investigate: (1) the role of signaling lymphocyte activation molecule (SLAM) and nectin-4 in PDV infection and their cellular expression patterns, (2) if PDV induces transcriptional regulation of cell-entry receptors, and (3) the involvement of apoptosis in PDV infection. PDV replicated in the lymph-node explants with peak replication 3 days post-infection (dpi), but the replication was not sustained 4 to 5 dpi. The PDV+ cells co-localized SLAM and nectin-4. These cells expressed IBA1, indicating a histiocytic lineage. Comparison of receptor expression between infected and mock-infected lymph nodes suggested transcriptional downregulation of both receptors during the initial stage of infection and upregulation during the late stage of infection, but the values lack of statistical significance. Cleaved caspase-3+ cells were slightly increased in the infected lymph nodes compared with the mock-infected lymph node from 1 to 4 dpi, but without statistical significance, and a few apoptotic cells co-expressed PDV. The results suggest that lymph-node explants might be an important model to study PDV pathogenesis. CSLs have the potential to be infected with PDV, as they express both cell-entry receptors in histiocytes. The lack of statistical significance in the PDV replication, transcriptional regulation of viral receptors, and changes in apoptosis suggest that although CSL might be infected by PDV, they might be less susceptible than phocid species.
Proliferative strongyloidiasis in a colony of colubrid snakes
Authors: Graham Erin A. , Los Kamp Eric W. , Thompson Nina M. , Tillis Steven B. , Childress April L. , Wellehan James F.X. , Walden Heather D.S. , Ossiboff Robert J.
Published: July 2023

Strongyloides are small rhabditid nematodes primarily associated with enteric disease in a variety of animal species, including reptiles. Strongyloides spp life stages were associated with a disease outbreak in a large breeding colony of snakes. Multiple Pantherophis and Lampropeltis colubrids exhibited respiratory distress, anorexia, stomatitis, facial deformation, and waning body condition that resulted in death or necessitated euthanasia. Postmortem examinations of 13 snakes revealed epithelial hyperplasia and inflammation of the alimentary and respiratory tracts associated with varying numbers of adult and larval nematodes and embryonated or larvated ova. In a subset of snakes, aberrant nematode migration was also observed in the eye, genitourinary system, coelom, and vasculature. Histomorphology and gross examination of parasitic adult female nematodes from host tissues were consistent with a Strongyloides spp. Sedimented fecal material from 101/160 (63%) snakes housed in the affected facility was positive for nematodes and/or larvated ova. Polymerase chain reaction amplification and sequencing of portions of the 18S and 28S ribosomal ribonucleic acid (RNA) genes and the internal transcribed spacer region of adult female parasites and positive fecal samples supported the diagnosis of strongyloidiasis. Strongyloides spp possess a unique life cycle capable of alternating between parasitic (homogonic) and free-living (heterogonic) stages, resulting in the production of directly infective larvae. Commonly utilized husbandry practices in reptile collections can amplify the numbers of infective larvae generated in the captive environment, increasing the risk for rhabditid hyperinfections. This report documents morbidity, mortality, and non-enteric disease manifestations due to Strongyloides hyperinfections in a captive colubrid snake colony.
Travel Time Prediction Utilizing Hybrid Deep Learning Models
Authors: Bharathi Dhivya , Sopeña Juan Manuel González , Clarke Siobhan , Ghosh Bidisha
Published: July 2023

Travel time prediction is vital to the development and maintainence of advanced intelligent transportation system technologies. The travel time on a road segment is dependent on various factors like dynamic traffic demands, incidents, weather conditions, and geometric factors. However, uncertainties associated with prediction performance consistency may reduce the effectiveness of such systems. To tackle these challenges, this paper proposes a hybrid deep learning algorithm-based methodology by integrating variational mode decomposition, multivariate long short-term memory, and quantile regression to predict estimates of travel time ranges instead of single-point predictions. Travel time data collected from loop detectors on motorways near the city of Dublin, Republic of Ireland were modeled. The proposed method was evaluated using various design scenarios and was found to perform efficiently in comparison with conventional deep learning algorithms.
Four Best Practices for Meta-Analysis: A Systematic Review of Methodological Rigor in Mathematics Interventions for Students With or at Risk of Disabilities
Authors: Park Soyoung , Lee Young Ri , Nelson Gena , Tipton Elizabeth
Published: July 2023

Meta-analysis methodology has evolved with the development of more robust statistical techniques; however, few reviews in special education have focused specifically on methodological rigor in meta-analyses. In this study, we examined 29 meta-analyses of mathematics interventions published from 2000 to 2022 to determine the extent to which researchers have applied four best practices in meta-analyses focused on mathematics interventions for students with disabilities. Our findings were (a) studies used three primary moderator techniques: meta-regression ( k = 10), subgroup analysis ( k = 8), analysis of variance ( k = 3), and both subgroup analysis and meta-regression ( k = 1); (b) only one study considered small sample corrections for hypothesis tests; (c) few researchers handled the dependence between multiple effect sizes ( k = 3); and (d) the funnel plot was commonly used to detect publication bias ( k = 8). Based on our findings, we make recommendations for methodological considerations for future meta-analyses.
Successful use of Rectal Pregabalin for the Treatment of Chemotherapy-Induced Neuropathic Pain—a Case Report
Authors: Roch Carmen , Para Servet , Brandhofer Christine , Seitz Anna K. , Rémi Constanze , Berner Jennifer , van Oorschot Birgitt
Published: July 2023

Introduction

A 65-year-old female patient could no longer take oral food or medications due to a duodenal occlusion associated with metastatic urothelial carcinoma. Her pre-existing chemotherapy-induced polyneuropathy had been well treated with pregabalin orally.

Methods

Since only preparations for oral use of pregabalin are available, pregabalin suppositories were compounded by the hospital pharmacy for rectal use in this patient.

Results

With the rectal administration, the treatment was successfully continued; we measured a good increase in serum levels and the symptoms improved significantly.

Discussion

Cancer patients often need to be treated with co-analgesics. At the end of life, treatment often cannot be continued due to lack of other than oral administration. Our case adds to the low evidence of pregabalin administered rectally.