bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatiotemporal Regulation of Tumor Angiogenesis by Circulating Chromogranin A Cleavage and Neuropilin-1 Engagement
Authors: Dallatomasina Alice , Gasparri Anna Maria , Colombo Barbara , Sacchi Angelina , Bianco Mimma , Daniele Tiziana , Esposito Antonio , Pastorino Fabio , Ponzoni Mirco , Marcucci Fabrizio , Curnis Flavio , Corti Angelo
Published: February 2019

The unbalanced production of pro- and antiangiogenic factors in tumors can lead to aberrant vasculature morphology, angiogenesis, and disease progression. In this study, we report that disease progression in various murine models of solid tumors is associated with increased cleavage of full-length chromogranin A (CgA), a circulating vasoregulatory neurosecretory protein. Cleavage of CgA led to the exposure of the highly conserved PGPQLR site, which corresponds to residues 368–373 of human CgA1-373, a fragment that has proangiogenic activity. Antibodies against this site, unable to bind full-length CgA, inhibited angiogenesis and reduced tumor perfusion and growth. The PGPQLR sequence of the fragment, but not of the precursor, bound the VEGF-binding site of neuropilin-1; the C-terminal arginine (R373) of the sequence was crucial for binding. The proangiogenic activity of the CgA1-373 was blocked by anti-neuropilin-1 antibodies as well as by nicotinic acetylcholine receptor antagonists, suggesting that these receptors, in addition to neuropilin-1, play a role in the proangiogenic activity of CgA1-373. The R373 residue was enzymatically removed in plasma, causing loss of neuropilin-1 binding and gain of antiangiogenic activity. These results suggest that cleavage of the R373R374 site of circulating human CgA in tumors and the subsequent removal of R373 in the blood represent an important “on/off” switch for the spatiotemporal regulation of tumor angiogenesis and may serve as a novel therapeutic target.

Significance:

This work reveals that the interaction between fragmented chromogranin A and neuropilin-1 is required for tumor growth and represents a novel potential therapeutic target.
LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response
Authors: Shahabi Shandy , Kumaran Vishaly , Castillo Jonathan , Cong Zhengmin , Nandagopal Gopika , Mullen Daniel J. , Alvarado Alexander , Correa Michele Ramos , Saizan Autumn , Goel Riya , Bhat Amrita , Lynch Sean K. , Zhou Beiyun , Borok Zea , Marconett Crystal N.
Published: February 2019

Lung cancer is the leading cause of cancer-related death in the United States. Long noncoding RNAs (lncRNA) are a class of regulatory molecules whose role in lung carcinogenesis is poorly understood. In this study, we profiled lncRNA expression in lung adenocarcinoma (LUAD) cell lines, compared their expression with that of purified alveolar epithelial type II cells (the purported cell of origin for LUAD), cross-referenced these with lncRNAs altered in the primary human tumors, and interrogated for lncRNAs whose expression correlated with patient survival. We identified LINC00261, a lncRNA with unknown function in LUAD, adjacent to the pioneering transcription factor FOXA2. Loss of LINC00261 was observed in multiple tumor types, including liver, breast, and gastric cancer. Reintroduction of LINC00261 into human LUAD cell lines inhibited cell migration and slowed proliferation by inducing G2–M cell-cycle arrest, while upregulating DNA damage pathway genes and inducing phosphorylation-mediated activation of components of the DNA damage pathway. FOXA2 was able to induce LINC00261 expression, and the entire locus underwent hypermethylation in LUAD, leading to loss of expression. We have thus identified an epigenetically deregulated lncRNA, whose loss of expression in LUAD promotes the malignant phenotype and blocks activation of the DNA damage machinery, predisposing lung cells to cancer development.

Significance:

These findings identify LINC00261 as a tumor suppressor that blocks cellular proliferation by activating the DNA damage response and suggest that epigenetic therapy to inhibit DNA methylation may enhance treatment of LUAD.
Assassination and Judicial Misconduct in Cold War Greece: The Polk/Staktopoulos Case in Retrospect
Authors: Iatrides John O.
Published: February 2019

In May 1948, as the Cold War escalated and the Communist insurgency in Greece intensified, the assassination of CBS News journalist George Polk in Salonica became an international cause célèbre. Polk had openly criticized the Greek government and questioned the U.S. government's support of an undemocratic regime. Most probably, he was killed trying to reach an insurgent command post to interview guerrilla leaders about the civil war. With no claims of responsibility for the murder and no credible forensic evidence, suspicions of culpability fell on many actors, including the Communists, extreme rightwing elements, common criminals, and rogue British intelligence operatives. Although responsibility for identifying and bringing to justice the guilty fell squarely on the Greek authorities, the country's heavy dependence on U.S. assistance enabled U.S. officials and journalists to influence the case. Eager to blame the crime on the Communists and produce quick results, Greek police and justice officials fabricated a case against two known Communists (never apprehended) and a small-time reporter, Gregory Staktopoulos, whose incoherent confessions were clearly coerced. Staktopoulos's trial, conviction, long imprisonment, and failed appeals to the country's highest court left an indelible stigma on Greek justice. Polk's murder—which has never been solved—and Staktopoulos's cruel fate illustrate the powerfully corrosive impact of Cold War perceptions and priorities on the institutions of Western democracies.
Shattered Hopes amid Violent Repression: The 1956 Hungarian Revolution and the United Nations (Part 2)
Authors: Nagy András
Published: February 2019

Few historical events over the past 70 years have rivaled the 1956 Hungarian revolution in its domestic and international impact. The research presented in the first part of this article (published in the Fall 2017 issue of the journal), which was based largely on recently declassified archival documents, focused on a specific aspect of the international response to the revolution—namely, the efforts of the United Nations (UN) to deal with urgent events during and immediately after the revolution. This second part focuses on the tragic consequences of the revolution, including trials, imprisonments, and executions, in the years that followed. The limitations of the UN in this instance have rarely been discussed, particularly by the organization's supporters. The silence surrounding these issues has affected dissidents and others throughout the world confronting dictatorial regimes. An understanding of what went wrong is crucial if the UN is to be more effective in the future.
Oreocharis panzhouensis (Gesneriaceae), a new species from karst regions in Guizhou, China
Authors: CAI LEI , GUO YING , ZHANG RONG-MEI , DAO ZHI-LING , WEN FANG
Published: February 2019

A new species of Gesneriaceae, Oreocharis panzhouensis, is described and illustrated from Panzhou City, Guizhou Province, China. The new species is morphologically similar to O. cavaleriei and O. forrestii in corolla shape and color, number of stigmas and stamens, but it can be easily distinguished by the shape of leaf blade and calyx, leaf blade indumentum, filament and pistil indumentum and length, and peduncle length.
A new Nucras Gray, 1838 (Squamata: Lacertidae) from the Strandveld of the Western Cape, South Africa
Authors: BAUER AARON M. , CHILDERS JACKIE L. , BROECKHOVEN CHRIS , MOUTON P. LEFRAS N.
Published: February 2019

A striking new sandveld lizard of the Nucras tessellata group is described from the Lambert’s Bay Strandveld of the Western Cape Province, South Africa. It is sister to the clade N. livida + N. tessellata, and is phenetically most similar to N. tessellata, from which it differs in its more elongate body and possibly increased number of presacral vertebrae and patternless orange dorsal coloration. The form elegans, described as a species by Andrew Smith (1838), but treated as an infrasubspecific variant by Broadley (1972), also exhibits weak patterning, but is likely a regional color variant. Nucras aurantiaca sp. nov. is the ninth member of the genus found in southern Africa. Its discovery in the well-collected coastal Western Cape suggests that further herpetofaunal surveys are needed in this region, which is threatened by agricultural activity and tourism-related development.
Influence of Tropical SSTs on the Interannual Variation of the Summer Monsoon Break over the Western North Pacific
Authors: Xu Ke , Lu Riyu , Kim Baek-Jo , Mao Jiangyu , Park Jong-Kil
Published: February 2019

The break of the western North Pacific (WNP) summer monsoon (WNPSM) occurs climatologically in early August and is accompanied by a remarkable suppression of convection over the ocean east of the Mariana Islands (10°–20°N, 140°–160°E). This suppression of convection is sandwiched between two convection peaks in late July and mid-August. Two types of monsoon break are identified in the interannual variation of the WNPSM break in the period 1979–2015, exhibiting a distinct subseasonal evolution of convection that is either in phase or out of phase with the climatological evolution. The preceding SST anomalies in the tropical WNP during early and mid-July are responsible for the interannual variation of the monsoon break. Warm (cold) SST anomalies induce an advanced (delayed) evolution of the WNPSM, with the establishment of strong convection in late July (early August) followed by a monsoon break in early August (mid-August). The subseasonal evolution of convection is therefore in phase (out of phase) with that of the climatological mean. The above SST anomalies mainly result from the local wind–evaporation–SST positive feedback during spring and summer. This local air–sea interaction is still robust after the linear regression components related to the variability of ENSO are excluded from the original fields, indicating that it is, to a large extent, independent of ENSO. The ENSO decaying phases have a secondary role in modulating the SST anomalies related to the WNPSM break.
A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency
Authors: Kaufmann Kerstin B. , Garcia-Prat Laura , Liu Qiang , Ng Stanley W. K. , Takayanagi Shin-Ichiro , Mitchell Amanda , Wienholds Erno , van Galen Peter , Cumbaa Christian A. , Tsay Mike J. , Pastrello Chiara , Wagenblast Elvin , Krivdova Gabriela , Minden Mark D. , Lechman Eric R. , Zandi Sasan , Jurisica Igor , Wang Jean C. Y. , Xie Stephanie Z. , Dick John E.
Published: February 2019

There is a growing body of evidence that the molecular properties of leukemia stem cells (LSCs) are associated with clinical outcomes in acute myeloid leukemia (AML), and LSCs have been linked to therapy failure and relapse. Thus, a better understanding of the molecular mechanisms that contribute to the persistence and regenerative potential of LSCs is expected to result in the development of more effective therapies. We therefore interrogated functionally validated data sets of LSC-specific genes together with their known protein interactors and selected 64 candidates for a competitive in vivo gain-of-function screen to identify genes that enhanced stemness in human cord blood hematopoietic stem and progenitor cells. A consistent effect observed for the top hits was the ability to restrain early repopulation kinetics while preserving regenerative potential. Overexpression (OE) of the most promising candidate, the orphan gene C3orf54/INKA1, in a patient-derived AML model (8227) promoted the retention of LSCs in a primitive state manifested by relative expansion of CD34+ cells, accumulation of cells in G0, and reduced output of differentiated progeny. Despite delayed early repopulation, at later times, INKA1-OE resulted in the expansion of self-renewing LSCs. In contrast, INKA1 silencing in primary AML reduced regenerative potential. Mechanistically, our multidimensional confocal analysis found that INKA1 regulates G0 exit by interfering with nuclear localization of its target PAK4, with concomitant reduction of global H4K16ac levels. These data identify INKA1 as a novel regulator of LSC latency and reveal a link between the regulation of stem cell kinetics and pool size during regeneration.
Taking a “BiTE out of ALL”: blinatumomab approval for MRD-positive ALL
Authors: Curran Emily , Stock Wendy
Published: February 2019

Blinatumomab, a bispecific T-cell engager (BiTE) associated with improved survival in relapsed or refractory acute lymphoblastic leukemia (ALL), was recently approved for treatment of minimal residual disease (MRD). MRD is an important predictor of survival in ALL, and recent studies suggest that achievement of MRD-negativity with blinatumomab improves outcomes in patients with ALL. However, further research is needed to determine how to optimally incorporate blinatumomab, and other novel therapies, into current therapies for ALL.
German (for economists)
Authors: Коплякова Екатерина , Koplyakova Ekaterina , Веселова Татьяна , Veselova Tat'yana
Published: February 2019

As a result of the work on this textbook, students will be able to master reading, listening, speaking and writing as types of speech activity.
This publication is intended for students enrolled in the field of training 38.03.01 "Economics", learning German at the senior stage in the system of full-time education.
PROPOSIÇÃO DA GOVERNANÇA RELACIONAL COMO FACILITADORA DA FUNCIONALIDADE DE REDES
Authors: Neroni João Baptista , Piuchi Roni , Lopes Ione , Giglio Ernesto Michelangelo
Published: February 2019

O artigo analisa a produção acadêmica sobre as categorias governança e funcionalidade de redes, buscando evidências de uma relação entre as duas. Uma linha de autores afirma que a governança, no sentido de um conjunto de mecanismos, práticas, partilha de valores e normas, é a matriz central que orienta as ações na rede. Neste artigo isto é denominado de funcionalidade da rede. No entanto, tal relação carece de sustentação em pesquisas. Para buscar as evidências dessa proposição realizou-se uma pesquisa bibliográfica nas bases Web of Science e Portal Capes. A seleção e análise do material pesquisado possibilitou o desenvolvimento de um desenho de pesquisa onde se detalham as variáveis componentes das duas categorias, assim como, a apresentação de alguns indicadores, o que pode ser utilizado como matriz de planejamento e execução de pesquisas sobre esse tema.
La Economía Social en tiempos de austeridad: el caso portugués
Authors: Ampudia de Haro Fernando
Published: February 2019

Durante la aplicación del programa de ajuste económico-financiero, el XIX Gobierno Constitucional portugués (PSD/CDS, 2011-2015) reivindicó la Economía Social (ES) como medio principal para responder a la situación de crisis vivida por el país. El objetivo de este artículo es analizar la visión proyectada de la ES desde el poder político en lo que toca a sus funciones, su articulación con las políticas públicas y su justificación moral. De este modo, se identifica el papel atribuido a la ES en un contexto de crisis a la vez que se determina en qué medida es posible discursivamente compatibilizar las iniciativas propias de la ES y las denominadas políticas de austeridad.Este trabajo toma como material empírico de referencia la producción documental del XIX Gobierno sobre la ES así como la comunicación pública de sus iniciativas en este terreno. Dicho material se analiza críticamente con el objeto de reconstruir la visión gubernamental de la ES como herramienta de combate al impacto social de la crisis. En un contexto de austeridad caracterizado por la desinversión en el sistema público de bienestar, el aumento del desempleo y el incremento de las formas de pobreza y exclusión social, dicha visión se asocia a la idea de paliativo frente a las insuficiencias de la acción estatal y las asimetrías del mercado.
Tokiko Garapen Agentzien eta Ekonomia Sozial eta Solidarioaren gaitasuna Tokiko Giza Garapenaren bidean: Agència de Desenvolupament del Bergueda-ren esperientzia aztergai
Authors: Zulaika Arriaga Andoni
Published: February 2019

El artículo que tenéis entre manos, parte del cuestionamiento del actual modelo económico y de desarrollo, y se centra en dar las claves para un nuevo modelo económico y de desarrollo que garantice el bienestar de todos los individuos.La hipótesis principal de la investigación se desarrolla en base a tres pilares fundamentales: Desarrollo Humano Local, Economía Social y Solidaria y Agencias de Desarrollo Local. Esta hipótesis defiende, de una forma tanto teórica como empírica, la capacidad de la Economía Social y Solidaria, como soporte económico, y las Agencias de Desarrollo que incorporan este paradigma económico, como herramientas institucionales, de cara a promover el Desarrollo Humano Local.
Pobrezia Energetikoa: Fenomenoaren hurbilketa kontzeptuala, Ekonomia Sozial eta Solidarioarekiko loturak
Authors: Domínguez Olabide Peru
Published: February 2019

Lan honek, inguru akademiko, mugimendu sozial, eta orokorrean, mendebaldeko gizartearen imaginario kolektiboan gero eta presentzia handiagoa lortu duen po-brezia energetikoaren gaiari hurbilketa bat egitea izan du helburu. Analisi honek, bi atal bereizi aurkezten ditu. Lehenengoan, fenomenoaren hurbilketa kontzeptual bat eginez, pobrezia energetikoaren literaturaren baitan aurkitu litezkeen bi joera teoriko nagusiak aurkezten dira, «ikuspegi dikotomikoa» eta «energia zerbitzuen ikuspegia» hurrenez hurren. Horrekin batera, kontzeptualizazio ariketa aberasteko asmoz, pobrezia energetiko eta pobrezia orokorraren arteko erlazioa aztertu da. Biak era bateratuan edo era bereizian aztertzearen egokitasuna, erabiltzen den pobrezia definizioaren araberakoa dela ondorioztatuz. Bigarren atalean, bestalde, pobrezia energetikoaren eta Ekonomia Sozial eta Solidarioaren artean egon dai-tezkeen lotura edota bidegurutze posibleak aztertu dira. Bi elkargune nagusi identifikatu dira ahalegin honetan. Lehena, Ekonomia Sozial eta Solidarioko erakun-deek energia pobreziaren ondorioak ikustarazteko izango luketen gaitasuna liteke. Bigarrena, erakunde beretsuek gabezia energetikoko egoerak ekiditeko neurri, estrategia eta ekintzak aurrera eramateko gaitasuna liteke. Azken honen baitan, hiru fronte nagusitan paper garrantzitsua lukete erakunde hauek, hala nola, identifikazioan, energia horniketan eta interbentzioan.
Financiación de asociaciones: examen especial del ejercicio de actividades económicas.
Authors: Palacios Ronda Esteban
Published: February 2019

La crisis económica ha conllevado un aumento de las necesidades de financiación de las asociaciones y, al tiempo, una disminución de sus recursos. Ante este escenario, examinaremos las distintas posibilidades existentes para obtener un marco financiero estable y, ante las limitaciones de que adolecen otros sistemas, concluiremos que la realización de actividades económicas se revela como la solución más realista. Sin embargo, este ejercicio tropieza con el disfavor de la administración, la cual considera, en no pocas ocasiones, que dicha alternativa conlleva la pérdida de su declaración de utilidad pública y en consecuencia de la posibilidad de optar por el régimen fiscal privilegiado propio de la Ley 49/2002, de 23 de diciembre, de régimen fiscal de las entidades sin fines lucrativos y de los incentivos fiscales al mecenazgo. Para contrastar esta afirmación utilizaremos como criterio metodológico el estudio de las dieciocho asociaciones que durante los años 2015 a 2018, tras ver revocada su declaración de utilidad pública, obtuvieron una resolución, favorable o desfavorable a sus pretensiones, por parte del Tribunal Supremo. El resultado de este análisis resultará abrumadoramente coincidente y nos permitirá contrastar la prevención administrativa ante la intervención privada en actividades de interés general.
Mengukur pengaruh kualitas layanan model CARTER terhadap kepuasan nasabah perbankan syariah Indonesia
Authors: Fauzi Abu Amar
Published: February 2019

Sharia banking in Indonesia continues to grow from year to year and there are currently 12 sharia commercial banks and 22 sharia business units of conventional banks. However, the market share of sharia banking is still less than 5% of the market share of conventional banking. This phenomenon proves that the existence of sharia banking on a dual banking system that runs in Indonesia is still a shadow of conventional banking. By using a CARTER model consisting of the dimensions of compliance, assurance, reliability, tangible, empathy, and responsiveness, this research is directed to explore the perception of customers to service quality dan its influence on customer satisfaction of sharia banking in Indonesia. Structural Equation Model (SEM) based on nonlinear regression techniques partial least square (PLS) on WarpPLS 5.0 is used to analyze the data obtained from a survey of 97 customers of Bank Muamalat Indonesia in Surabaya. These results indicate that the service quality of sharia bank has a significant relationship with customer satisfaction. Empathy has the most powerful influence on customer satisfaction of sharia bank. Yet, compliance becomes the lowest dimension of service quality that affects customer satisfaction in Indonesia sharia banks.
Pengaruh niat berperilaku dan kecerdasan spiritual terhadap pengelolaan keuangan keluarga
Authors: Faridawati Ririt , Silvy Mellyza
Published: February 2019

Family financial-management is vital for achieving a financial well-being. When a family has a barely-enough income that is managed properly and wisely, it is possible that the family can live peacefully, happily, and prosperously. Although people know the importance of family financial- management, there are still many families who haven’t applied a financial management in their families. This study aimed to examine the impact of behavioral intention and spiritual intelligence on family financial-management. The sample was taken from financial managers of families that live in Gresik, Surabaya, Sidoarjo, and Mojokerto. The sample was taken using a purposive sampling based on family income with a minimum total income Rp 4,000,000/month and snowball sampling. The data were taken by distributing the questionnaires. The results show that the behavioral intention has a positive and significant effect on family financial-management and spiritual intelligence laso has a positive impact but not significant on family financial-management.
Literasi keuangan dan pengelolaan keuangan keluarga dalam perspektif budaya Jawa dan Bugis
Authors: Purniawati Reni Tri , Lutfi Lutfi
Published: February 2019

Consumptive behavior can negatively affect family welfare. Financial literacy is one of the factors which may affect family financial management behavior. This family financial may differ across ethnic groups due to the different characters and principles of life among them. This study aimed to examine the effect of financial literacy on family financial management using ethnic as a moderating variable. This study uses a questionnaire instrument that is distributed to 140 respondents of Javanese in Madiun residency and 96 respondents of Bugis at Makassar, East Sulawesi. The data analysis technique is multiple regression analysis. This research use purposive sampling and convenience sampling as the sampling technique. The result of this study shows that financial literacy positively affect family financial management behavior, while ethnic does not moderate the effect of financial literacy on family financial management behavior. This study suggests that families, both Javanese and Bugis, need to enhance their financial literacy to enable them to manage their finance well so that they can improve their welfare.
Fluktuasi indeks harga saham industri jasa sektor property dan real estate dengan determinan faktor ekonomi makro
Authors: Jazuli Muhammad Fiqhuddin , Iramani Iramani
Published: February 2019

Capital market have very important macroeconomic’s indicator for a country. The purpose of this study is to examine the effect of macroeconomic factors to the stock price index of property and real estate. In this study used purposive sampling method as determining the sample and multiple linear regression analysis. The result is in a whole inflation, interest rate, balance of payments, and Gross Domestic Product have significant effect to Stock Index Property and Real Estate Sector. Partially, inflation has a negative significant effect on the Stock Price Index, while interest rates, Balance of Payments and Gross Domestic Product have no effect.
The effect of corporate social responsibility (csr) on Brand image in PT. PLN (persero)
Authors: Harimurti Rosa , Lindiawati Lindiawati
Published: February 2019

Corporate Social Responsibility (CSR) is one of strategicmarketing concept son social causes. The purpose of this study is to explain the influence of CSR’s dimension on dimension of brand image in PLN Company in Indonesia. This study focuses on legal and ethical responsibilities that can enhance the positive functional and symbolic image. Sample of this study are 110 consumers that was chosen used on random sampling techniques in Mojokerto and data collected by questionnaires. The anlysis tool used is Partial Least Squares (PLS). The empirical results indicate that corporate legal responsibility has significantly effect on functionalimage but legal responsibility does not significantly effect on symbolicimage. Next, ethical responsibility has significant effect on both functionalimage and symbolicimage. Legal responsibility helps enhancing the functional image than symbolic image, meanwhile the ethical responsibility helps enhancing the symbolic image than functional image. The suggestion is that if firms should focus on one aspect of theCSR’s dimension to enhance the brand image.
Apakah profitabiltas, risiko keuangan dan ukuran perusahaan meningkatkan praktik perataan laba perusahaan?
Authors: Banjarnahor Erliana , Curry Khirstina
Published: February 2019

Earnings Management is the selection accounting policies by management to achieve certain goals. The usual way of management to influence the numbers on the financial statements is to make earnings management one of them with income smoothing. The purpose of this research is to test empirically the influence of profitability, financial risk, and company size to the practice of income smoothing. Population in this research is all public company year 2012-2016, while for sample of research use purposive sampling method, with secondary data. Methods of data analysis using binary logistic regression. The result obtained is profitability does not affect the income smoothing action. Financial risk does not affect earnings smoothing. Firm size affects earnings smoothing action. Positive influence means that if the size of the company the higher the company doing income smoothing.
Pengambilan keputusan investasi Investor di pasar modal indonesia ditinjau dari Teori reasoned action
Authors: Listyarti Indra
Published: February 2019

Penelitian ini bertujuan untuk mengkaji factor-faktor yang mempengaruhi perilaku investor ketika melakukan keputusan investasi ditinjau dari Teori Reasoned Action. Penelitian melibatkan 190 investor di pasar modal Indonesia  dan analisis  dilakukan dengan regresi linier berganda. Uji hipotesis dengan t-test untuk menguji pengaruh variabel independen secara parsial terhadap variabel dependen.  Hasilnya menunjukkan bahwa Faktor  Makro berpengaruh positif  signifikan terhadap informasi teknikal.  Informasi  keuangan, faktor makro dan norma subyektif  berpengaruh positif dan signifikan terhadap niat investor. Niat investor dan informasi keuangan berpengaruh positif signifikan terhadap keputusan investasi. Lebih jauh hasil penelitian ini menjelaskan bahwa informasi keuangan memegang kontribusi besar dalam membentuk niat investor dan keputusan investasi.
The influence of tax, tunneling incentive, and bonus mechanisms on transfer pricing decision in manufacturing companies
Authors: Indriaswari Yasfiana Nuril , Nita Riski Aprillia
Published: February 2019

Transfer pricing is a way conducted by a multinational company to do tax avoidance. Concentrated ownership structure makes the majority shareholders tend to perform a tunneling incentive that could harm minority shareholders. Companies that set bonus mechanism based on the profits will make the management or the board of directors tend to conduct profit manipulation. The aim of this research is to analyze the influence of tax, tunneling incentive and bonus mechanism on transfer pricing decision taken by manufacturing companies listed on the Indonesia Stock Exchange. The sample used on this study is manufacturing companies listed on the Indonesia Stock Exchange in 2012-2014 totaling 69 companies taken using purposive sampling method. The analysis technique used in this study is analysis binary logistic regression. The result of this study shows that tax and tunneling incentive have significantly influence on transfer pricing, while bonus mechanism does not have significant influence on transfer pricing
The effect of management change, audit opinion, and financial distress on auditor switching
Authors: Augustyvena Endistria Verosa , Wilopo Romanus
Published: February 2019

To avoid undesirable things related to auditor independence, some companies take an action to make mandatory auditor switching, but on the other hand, many other compa-nies make voluntary auditor switching. This study, therefore, aims to find out empirical evidence related to the factors, such as management changes, audit opinion, and financial distress, which affect the manufacturing companies to do voluntary auditor switching. The data used in this research are consumer goods industry sector companies listed on the Indonesia Stock Exchange during 2011-2015. A total of 33 manufacturing compa-nies are used as the sample. Analysis method used is logistic regression analysis. Overall, the finding shows that there is no significant evidence that management change, audit opinion, and financial distress have an effect on auditor switching. Suggestion for the future research is to extend survey area coverage and to add more variables that can influence auditor switching.
Proses Penerbitan Buku dan Kebijakan Pemberian Royalti kepada Penulis di Penerbit Insan Madani Yogyakarta
Authors: Rifauddin Machsun
Published: February 2019

Industri penerbitan buku harus tetap eksis di era globalisasi untuk mewadahi hasil karya para penulis, dan tetap memberikan royalti yang pantas. Penelitian ini bertujuan untuk untuk menjelaskan bagaimana system royali pada perjanjian penerbitan buku di Penerbit Insan Madani Yogyakarta. Penelitian ini menggunakan pendekatan kualitatif dengan studi lapangan, dan pengumpulan data dilakukan dengan wawancara dan observasi. Hasil penelitian menunjukkan bahwa Penerbit Insan Madani menerapkan dua konsep pemberian royalti kepada penulis buku. Pertama, adalah sistem 10% dari harga jual dipotong pajak 15% dimana royalti dibayarkan dua kali dalam setahun, dan kedua dengan sistem beli putus dimana sebuah naskah akan dibayar langsung ke penulis begitu bukunya diterbitkan. Pemberian royalti sudah sesuai dengan strandar umumnya yaitu 10% dari harga buku setelah dipotong pajak 15%. Permasalahan dalam perjanjian penerbitan buku dan royalti adalah apabila buku tidak laku dipasaran atau dijual dengan harga dibawah standar maka diperlukan perjanjian ulang.
Pengekang Crossties di Zona Tekan Balok dengan Pembebanan Siklik
Authors: Priastiwi Yulita Arni , Imran Iswandi , Nuroji Nuroji , Hidayat Arif
Published: February 2019

Crossties that was installed as a confinement in the compression zone of the beam is proven can increase the ductility, especially when receiving the earthquake load. Using an experimental study, this paper  explains  the effect of crossties which was installed in compression zone of the beam. The model was a simplification of the plastic hinge of the beam. The beam was enlarged in the center of the span and would be loaded with a cyclic of point load, so as to produced the largest moment and shear fields in the face beam of the column. Moreover, the loading was provided by the displacement control system to achieve the ultimate condition. The results show that the crossties significantly increases the displacement and curvature ductility of the beams of 58.7% and 78.2%, respectively, compared to the beam without confinement. In addition, the load cycle formed by cyclic loading increases to 43 cycles in beam with crossties, meanwhile the beam without confinement can only survive up to 33 cycles. The crossties could also increase the cumulative value of inelastic displacement that occurs up to 98%, whereas its  energy dissipation value is six times than the beam without confinement. On the other hand, the maximum load and capacity moment only increase about 6.5%.
First record of Caulerpa prolifera in the Azores (NE Atlantic)
Authors: Cacabelos Eva , Faria João , Martins Gustavo M. , Mir Carles , Parente Manuela Isabel , Gabriel Daniela , Sánchez Rocío , Altamirano María , Costa Ana Cristina , Prud’homme van Reine Willem , Neto Ana Isabel
Published: February 2019

This paper reports a recently discovered population of Caulerpa prolifera in the Azores (NE Atlantic), which becomes the westernmost record of this species in European waters. Morphological, anatomical and molecular characters were investigated for species recognition. The occurrence of the species in the Azores represents a northern expansion of its distributional range, covering now the whole Macaronesia region. It may have been brought by rafting from the western Atlantic through the Gulf Stream, but human-assisted transport may also have been involved in its arrival or dispersion.
Sociopragmatic factors and melodic patterns: Spanish vocatives and imperatives compared
Authors: Robles-Puente Sergio
Published: February 2019

Due to their addressing nature, vocatives and imperatives have been said in multiple occasions to have the same function and similar phonological characteristics. The aim of this paper is to examine the intonational link between these two kinds of sentences in Peninsular Spanish considering sociopragmatic and situational factors like the level of formality and the degree of insistence. In order to do so, twenty-eight native speakers of Peninsular Spanish produced isolated names and verbs in formal and informal settings followed by insistent productions. The phonetic and phonological analyses of 1232 one-word productions indicate that both speech acts share multiple contours; namely L* H%, L + H* HL%, L + H* !H%, L + H* L%, L + H* H%, L + H* LH%. Nevertheless, L + H* L% was the most used contour for both speech acts regardless of the sociopragmatic and situational factors. Interestingly, speakers modified the phonetic properties of intensity and F0 depending on the situation since informal and insistent productions had a higher F0, wider pitch excursions and more intensity than their formal and non-insistent counterparts. As alternatives, L* L% contours were attested in formal imperatives while L + H* LH% and L + H* HL% were more common in informal ones. After L + H* L% contours, L + H* HL% and L* H% were the preferred options in formal vocatives but the latter was hardly attested in informal ones.
Augmented Powell-Based Krill Herd Optimization for Roadside Unit Deployment in Vehicular Ad Hoc Networks
Authors: Saravanan D. , Janakiraman S. , Chandraprabha K. , Kalaipriyan T. , Raghav R. S. , Venkatesan S.
Published: February 2019

This article focuses on roadside unit (RSU) deployment based on the analysis of aggregation delay causes between the accident-occurring location and the nearby RSU. Information aggregation in vehicular ad hoc networks using RSU is one of the phenomenal concepts that look ahead in today’s recent advancements, since the consistency in aggregation and dissemination of data in a volatile network is high when compared with vehicle to vehicle communications. Deploying the RSU as appropriate in rural areas is cost-sensitive since the collection of information is not up to the mark when compared with urban regions. A mathematical model called Powell’s Method and a bioinspired algorithm, namely krill herd algorithm, have been hybridized and proposed in this research article for effective RSU deployment. The proposed algorithm has been tested under three different road maps, and the consistency of the algorithm has been evaluated under appropriate performance measures.
SRT1720 retards renal fibrosis via inhibition of HIF1A/GLUT1 in diabetic nephropathy
Authors: Han Weixia , Wang Chen , Yang Zhifen , Mu Lin , Wu Ming , Chen Nan , Du Chunyang , Duan Huijun , Shi Yonghong
Published: February 2019

Renal fibrosis is the major pathological characteristic of diabetic nephropathy (DN). Reportedly, increased SIRT1 expression played a renal protective role in animal models of DN. This study was designed to elucidate the molecular mechanisms underlying the protective effects of SRT1720, an SIRT1 activator, against diabetes-induced renal fibrosis. Type 2 diabetic mice (db/db) were treated with SRT1720 (50 mg/kg/day) by gavage for 10 weeks. Renal proximal tubular epithelial cells (HK-2 cells) were treated with high glucose (HG, 30 mM) in the presence or absence of SRT1720 (2.5 µM) for 48 h. We observed that impaired SIRT1 expression and activity were restored by SRT1720 administration in db/db mice as well as in HG-treated HK-2 cells. Moreover, SRT1720 administration improved the renal function, attenuated glomerular hypertrophy, mesangial expansion, glomerulosclerosis and interstitial fibrosis and inhibited TGFB1 and CTGF expressions and nuclear factor κB (NF-KB) activation in db/db mice. Similarly, HG-induced epithelial-to-mesenchymal transformation (EMT) and collagen IV and fibronectin expressions were inhibited in SRT1720-treated HK-2 cells. Mechanistic studies demonstrated that SRT1720 suppressed HIF1A, GLUT1 and SNAIL expressions both in vivo and in vitro. Furthermore, HIF1A or GLUT1 knockdown effectively abrogated HG-induced EMT and collagen IV and fibronectin expressions in HK-2 cells. These findings suggest that SRT1720 prevented diabetes-induced renal fibrosis via the SIRT1/HIF1A/GLUT1/SNAIL pathway.
Los criterios interpretativos del Consejo de Transparencia. Alcance y significado
Authors: Neira Barral Daniel
Published: February 2019

El art. recensiona y analiza los criterios interpretativos del Consejo de la Transparencia y Buen Gobierno. La aprobación de la LETAI y las competencias atribuidas en ella al Consejo de la Transparencia obliga a abordar los distintos criterios que esta institución va dictando al objeto de clarificar los problemas que puedan generar las interpretaciones de los preceptos contenidos en la ley. Todo ello para dar cumplimiento a la propia naturaleza de este consejo como órgano de control, de divulgación o informador cuando no clarificador del derecho de acceso a la información y transparencia.
Modeling Heterogeneity in the Genetic Architecture of Ethnically Diverse Groups Using Random Effect Interaction Models
Authors: Veturi Yogasudha , de los Campos Gustavo , Yi Nengjun , Huang Wen , Vazquez Ana I , Kühnel Brigitte
Published: February 2019

In humans, most genome-wide association studies have been conducted using data from Caucasians and many of the reported findings have not replicated in other populations. This lack of replication may be due to statistical issues (small sample sizes or confounding) or perhaps more fundamentally to differences in the genetic architecture of traits between ethnically diverse subpopulations. What aspects of the genetic architecture of traits vary between subpopulations and how can this be quantified? We consider studying effect heterogeneity using Bayesian random effect interaction models. The proposed methodology can be applied using shrinkage and variable selection methods, and produces useful information about effect heterogeneity in the form of whole-genome summaries (e.g., the proportions of variance of a complex trait explained by a set of SNPs and the average correlation of effects) as well as SNP-specific attributes. Using simulations, we show that the proposed methodology yields (nearly) unbiased estimates when the sample size is not too small relative to the number of SNPs used. Subsequently, we used the methodology for the analyses of four complex human traits (standing height, high-density lipoprotein, low-density lipoprotein, and serum urate levels) in European-Americans (EAs) and African-Americans (AAs). The estimated correlations of effects between the two subpopulations were well below unity for all the traits, ranging from 0.73 to 0.50. The extent of effect heterogeneity varied between traits and SNP sets. Height showed less differences in SNP effects between AAs and EAs whereas HDL, a trait highly influenced by lifestyle, exhibited a greater extent of effect heterogeneity. For all the traits, we observed substantial variability in effect heterogeneity across SNPs, suggesting that effect heterogeneity varies between regions of the genome.
Evaluation of Transitions for Land Functions in Subak Bulan, Mengwi, Badung District
Authors: I Nengah Subagia Ir. I Made Letra, M.Si Wayan Giatmajaya,
Published: February 2019

Subak is a traditional irrigation organization that has existed in Bali for approximately 1000 years. This traditional institution has a socio-religious pattern based on a high spirit of mutual cooperation. Subak is very effective as a buffer for agricultural development in Bali, which is a noble value that is inherited so it needs to be preserved. Today's developmental development has begun to urge subak culture both elements of war. Pawongan and its weakness. In the subak region of Mengwi Month, land conversion has begun due to several factors. This study aims to find out what factors influence function transfer whether due to water withdrawal, population development, or community behavior / subak krama. The method used is descriptive and correlational and the data is taken from water withdrawal, open debiet, interview using a questionnaire. The results of this study indicate that subak Bulan debiet irrigated irrigated water is highly influenced by the season, so it depends on the discharge of the spring in the subak Bulan region. Water extraction was very detrimental to farmers, function change has occurred in the last five years reaching 5.25 ha caused by several factors including; uptake of water upstream, opening of new roads, opening of housing. This study can be concluded, there is a lack of water in subak Bulan uneven and fluctuating which is influenced by the season. Need to re-plan existing irrigation networks. Water resources need to be maintained, managed wisely and preserved. The government needs to make regulations on water governance, especially in subak Bulan so that there is no conflict of interest in the water user community.
State of health literacy in higher education (M.H.S.A & M.H.A programs) in the U.S.
Authors: Kim Dae Hyun , Standish Melanie , Kim Soojin
Published: February 2019

This article was migrated. The article was not marked as recommended. Only 12% of the American adults are considered proficiently health literate. Limited health literacy is known to be associated with avoidance of seeking access to healthcare and poor adherence of healthcare instructions. While majority of the research of has been focused on the health literacy level of patients, nurses, and the physicians, few studies have focused on hospital CEOs. While hospital CEOs come with diverse educational backgrounds, Master of Health Services Administration (M.H.S.A) and Master of Health Administration (M.H.A) are known as programs that "groom" future leaders in healthcare. This is why this paper examines if M.H.S.A and M.H.A programs put much emphasis on health literacy. Descriptive analysis was done to examine top 5 ranked M.H.S.A and M.H.A programs' vision, mission statements, and competency models and whether there was any mention of the word 'health literacy.' The result shows that none of the selected programs' vision, mission statements, and competency models mentioned anything in regards to 'health literacy.' If programs fail to stress the importance of health literacy, future hospital CEOs will lack the knowledge regarding the importance of health literacy.
Cirurgia híbrida na exérese de tumor glômico Shamblin II
Authors: Amato Alexandre Campos Moraes , Ferreira Diego Daniel Gomes , Silva Fernanda Teixeira Fonseca da , Uemura Marielly Ayako , Stucchi Thais de Oliveira , Santos Ricardo Virgínio dos
Published: February 2019

Resumo O tumor glômico é uma neoplasia benigna rara originada de células paraganglionares da crista neural que se desenvolve na camada adventícia do vaso. São tumores não encapsulados e altamente vascularizados. Paciente feminina, 64 anos, foi diagnosticada com tumor glômico hipervascularizado com 5 cm posteriormente à bifurcação carotídea esquerda e oclusão de carótida contralateral. Optou-se por realizar embolização através de acesso endovascular seguida de punção percutânea direta, guiada por angiografia, para preenchimento da área remanescente. Após embolização, realizou-se a exérese cirúrgica do tumor com menor sangramento e maior facilidade para encontrar o plano de clivagem das estruturas adjacentes. Em acompanhamento tardio, a paciente apresenta-se sem recidiva tumoral. O tumor foi classificado como pertencente ao grupo Shamblin II, o qual inclui tumores apresentando de 4 a 6 cm com inserção arterial moderada. Através dessa dupla abordagem, foi possível notar uma redução relativa do sangramento intraoperatório e facilitação de identificação do plano de clivagem, colaborando para sua exérese e evitando o pinçamento cirúrgico.
Percepção de mães sobre cuidados de saúde bucal ofertados na residência em Neonatologia
Authors: DINIZ Angélica , ALVES Fabiana BUCHOLDZ TEIXEIRA , GALVAN Jessica , ZANESCO Camila , BORDIN Danielle , FADEL Cristina BERGER
Published: February 2019

Resumo Introdução A avaliação materna acerca da oferta de serviços de saúde destinada ao cuidado em saúde de neonatos destaca-se como importante referencial de qualidade, no âmbito hospitalar. Objetivo analisar a percepção de mães sobre cuidados de saúde bucal trazidos por profissionais de Odontologia residentes em Neonatologia. Material e método Trata-se de uma pesquisa descritiva com abordagem qualitativa às mães de neonatos que estiveram internados na Unidade de Terapia Intensiva Neonatal do Hospital Universitário Regional dos Campos Gerais. Resultado Inicialmente, a informação da presença do cirurgião-dentista na equipe de cuidados à saúde neonatal foi encarada com surpresa pelas participantes, porém somente até que a ações fossem destacadas. Após o esclarecimento, a maioria das entrevistadas expressou satisfação, motivação e segurança em relação ao atendimento odontológico e admiração pela oferta deste serviço de saúde, em um hospital público. Conclusão A percepção da participação do cirurgião-dentista na equipe de saúde foi avaliada de maneira positiva pelas mães participantes, ao ser evidenciada a atuação deste no âmbito hospitalar. O levantamento realizado fortalece a necessidade de continuidade e ampliação das ações de promoção e prevenção em saúde, promovendo, desta forma, o incentivo precoce e o empoderamento das mães e familiares de neonatos.