bluuebunny/crossref_metadata_2025 huggingface dataset:
“In the Way of Progress”: How a Federal Highway and Political Fragmentation Blighted Neighborhoods in the Weequahic Section of Newark
Authors: Johnson, Jr. John
Published: July 2023

This paper chronicles the history of interstate highway construction through the Weequahic Section of Newark, New Jersey. It expands the analysis of urban redevelopment in Newark, New Jersey, by shifting the focus from the Central Ward, the primary site of urban renewal, to the Weequahic Section, one of several districts in the broader Newark landscape. Tracing how urban renewal led to a broader set of changes in the Newark cityscape, this paper examines how city and state officials exploited Newark’s geographic resources, not for the benefit of Weequahic residents or Newark citizens more generally, but for downtown and regional commercial interests, and suburban commuters. Using newspapers to map out the chronology of events; municipal and state studies, and official correspondence to document state intentions and policy decisions; and organizational minutes, flyers, and correspondence to discern local reactions to highway construction, this work will show that the construction of the highway through Weequahic was not inevitable.
Murder on the Mountain: Crime, Passion, and Punishment in Gilded Age New Jersey
Authors: Lurie Jonathan
Published: July 2023

Jonathan Lurie reviewing Murder on the Mountain: Crime, Passion, and Punishment in Gilded Age New Jersey, by Peter Wosh and Patricia Schall.
Book Review: With a Zest and in a Refined Form…The 7th International Congress of Historical Sciences in Warsaw, 1933
Authors: Błażejczyk-Majka Lucyna
Published: July 2023

Makowski, K.A., Michalski, M., Schramm, T. (eds), Filipowska, K. (col.) (2021) With a Zest and in a Refined Form… The 7th International Congress of Historical Sciences in Warsaw, 1933, Poznań: Wydawnictwo Miejskie Posnania, Fundacja TRES.
Phytochemical analysis and anticancer activity of the Pithecellobium dulce seed extract in colorectal cancer cells
Authors: Alhamed Abdullah S. , Alqinyah Mohammed , Alghaith Adel F. , Algahtani Mohammad M. , Alqahtani Faleh , Nasr Fahd A. , Alqahtani Ali S. , Noman Omar M. , Bazaid Abdulrahman S. , AlMalki Reem Hussain , Abdel Rahman Anas M. , Alhazzani Khalid , Alanazi Ahmed Z.
Published: July 2023

Colorectal cancer remains a challenging medical issue worldwide, and utilizing natural products and plants to produce novel, effective and safe therapies against this disease is continuously a sought-after strategy. Fruit and leaf extracts of Pithecellobium dulce (P. dulce) showed potential anticancer properties as they induced apoptosis of breast cancer and Dalton’s lymphoma ascites cells. Thus, the main objective of the current study is to determine whether the seed extract of P. dulce will affect apoptosis, cell cycle, migration, and inflammation of LoVo colorectal cancer cells. The high-resolution liquid chromatography–mass spectrometry was used to determine the chemical composition of the P. dulce seed extract, which revealed the presence of 35 phytochemicals. The findings of this study indicated a significant cytotoxic effect of seeds of this plant in colorectal cancer characterized by induction of apoptosis, cell cycle arrest, and reduction of migration. In addition, the seed extract suppressed several genes that are essential for cancer progression such as MMP2, MMP9, and IL-8, and, on the other hand, upregulated pro-apoptotic genes such as BAX and P53. This study has established P. dulce as a potential and valuable source for providing future therapies against colorectal cancer and other cancers.
Performance analysis on the structure of the bracket mounting for hybrid converter kit: Finite-element approach
Authors: Effendi Ma’ruf Yanuar , Ubaidillah Ubaidillah , Budiana Eko Prasetya , Lenggana Bhre Wangsa
Published: July 2023

An electric motor mounting bracket is used in electric vehicles, especially hybrid ones using a parallel hybrid configuration. This study aims to analyze the strength and performance of the initial design and topology optimized design. This study uses the finite-element method (FEM) in the bracket design modeling by applying topology optimization. The topology optimization results show a mass reduction of 50% from the initial design mass. In the case of static loading, the results of optimized design 2 have a stress of 142.19 MPa and a safety factor of 3.09. While optimized design 1 has a stress of 313.8 MPa and a safety factor of 1.4. In terms of dynamic loading, the initial design, optimized design 1, and optimized design 2 have the first natural frequency, which is higher than the operating frequency of the electric motor, respectively, 100.49, 69.043, and 74.864 Hz. Optimized design 1 has the lowest natural frequency and the highest amplitude compared to the initial design, and optimized design 2 has lower damping characteristics. The study results conclude that optimized design 2 is superior in static and dynamic loading.
“That’s all it takes to be trans”: counter-strategies to hetero- and transnormative discourse on YouTube
Authors: Bruns Hanna
Published: July 2023

The discourse surrounding transgender people has for a long time been influenced by certain narrative practices necessary to authenticate people’s trans status to medical professionals. This conventional narrative (master narrative), based on ideals of hetero- and cisnormativity, has led to stereotypical representations of trans identities. These largely continue to exist today. Nevertheless, counter-discourse to these stereotypical representations is becoming more prominent. Particularly YouTube has become an increasingly popular platform for counter-discursive action. The current case study therefore focusses on two transgender YouTubers who challenge the normative ideals by creating their own counter-discourse. The YouTubers address four major topics of stereotypical representation: the ideal of binary gender, heterosexuality, the wish to transition in order to pass as cisgender, and the belief that transgender people have always identified as the other gender. The two creators recognise the discursively reproduced stereotypes and use a combination of five different strategies to refute them: Inversion, Parody, Complexification, Shift, and Personal Experience. Making use of these strategies, the subjects’ positive discourse aims at presenting a multi-faceted representation of transgender identities.
A case of concomitant leukemoid reaction and mucormycosis in a patient with severe COVID-19 infection
Authors: Sayed Issa Rand , Mushtaq Gohar , Unnisa Aziz , Mahli Abdo
Published: July 2023

Objectives

Leukemoid Reaction (LR) signifies leukocytosis characterized by mature neutrophils. The incidence of LR is about 1 % among hospitalized patients. Mucormycosis is a rare, aggressive, fatal fungal infection that afflicts immune-compromised patients. This study discusses the case of concomitant leukemoid reaction and mucormycosis in a patient with severe COVID-19 infection.

Case presentation

A 45-year-old female patient was presented to the hospital with confirmed SARS-CoV-2 and was given supplemental oxygen and placed on mechanical ventilation. Her skin biopsy revealed non-septate hyphae with wide-angle branching. Her blood tests also revealed the presence of LR.

Conclusions

Severe COVID-19 infection causes new-onset hyperglycemia, which can lead to metabolic acidosis, toxic metabolite accumulation in the body due to renal failure, the release of stress hormones and inflammatory cytokines, and the occurrence of secondary bacterial and opportunistic fungal infections. The study has shown that LR in severe COVID-19 may be associated with severe infections (bacterial or fungal) and other pathophysiological changes in the body.
EHMT2 affects microglia polarization and aggravates neuronal damage and inflammatory response via regulating HMOX1
Authors: Yang Huaitao , Chen Zhifang , Gao Wenhong
Published: July 2023

Objective

This research was designed to ascertain the function of euchromatic histone lysine methyltransferase 2 (EHMT2) in ischemic stroke-induced neuronal damage and inflammatory response and its regulatory mechanism.

Methods

Mouse microglia (BV-2 cells) were induced by oxygen glucose deprivation/reoxygenation (OGD/R) to establish a cellular model, and then co-cultured with HT22 hippocampal neurons. After that, HT22 cell viability and apoptosis were evaluated, followed by the measurement of apoptosis-related factors (B-cell lymphoma-2, Bcl-2 associated X, and cleaved-Caspase 3). Meanwhile, the expression of inducible nitric oxide synthase (M1 microglia polarization marker) and arginase 1 (M2 microglia polarization marker) in BV-2 cells was detected, as well as the levels of inflammatory factors (tumor necrosis factor-α, interleukin [IL]-6, IL-10, IL-1β, and IL-4). Additionally, the expression of EHMT2 and heme oxygenase 1 (HMOX1) in BV-2 cells was assessed by quantitative reverse transcription polymerase chain reaction and western blot, and the binding between EHMT2 and HMOX1 was predicted and verified.

Results

OGD/R treatment led to decreased cell viability and increased cell apoptosis in HT22 cells, and aggravated inflammatory response in BV-2 cells. In OGD/R-induced BV-2 cells, EHMT2 and HMOX1 were increasingly expressed, and knockdown of EHMT2 or HMOX1 in BV-2 cells could inhibit neuronal damage and inflammatory response. Moreover, EHMT2 promoted HMOX1 transcription level by histone methylation.

Conclusion

Collected evidence showed that down-regulation of EHMT2 relieved neuronal damage and inflammatory response by inhibiting HMOX1 expression.
Del indigenismo mexicano al cine indígena en Michoacán
Authors: Chávez Rojas Karina Lizeth
Published: July 2023

Con el presente trabajo se hace una revisión y análisis de las circunstancias sociohistóricas y políticas en que se suscribe el ideario nacionalista y su configuración identitaria. Consideramos que esto no sólo posibilitó la promoción de determinados proyectos de nación, también es apoyatura para explicar el surgimiento y los rasgos distintivos del cine indígena mexicano, específicamente el realizado en Michoacán. Para tal efecto, se han contemplado los siguientes momentos históricos: 1. La estética europea como modelo a seguir en los primeros registros de lo indígena y los indígenas a finales del siglo XIX. 2. La reconstrucción nacional posrevolucionaria. 3. El indigenismo institucional e intelectual como guía de los proyectos de nación. 4. Cine etnográfico y televisión, nuevos refuerzos para el indigenismo mexicano. 5. Neoindigenismo y producción comunitaria: primera mirada indígena y surgimiento de un discurso descolonizador. 6. Rasgos teleológicos del cine indígena michoacano.
Úrsula Camba, Persecución y modorra. La Inquisición en la Nueva España
Authors: Galicia Rendón Daniela , López Meraz Oscar Fernando
Published: July 2023

Reseña a: Úrsula Camba, Persecución y modorra. La Inquisición en la Nueva España
Gloria Celia Carreño Alvarado, Los archivos privados como fuente de información para la historia de México
Authors: Rivera Rodríguez Daniel
Published: July 2023

Reseña a: Gloria Celia Carreño Alvarado, Los archivos privados como fuente de información para la historia de México
La producción textil en el Bajío guanajuatense, 1826-1911
Authors: Sánchez Rangel Oscar
Published: July 2023

En este artículo se estudia el comportamiento de la producción textil en Guanajuato durante un periodo en que avanzó la mecanización de dicha actividad en México. Tales problemáticas han sido poco exploradas en la historiografía guanajuatense, mientras que la minería y la agricultura han tenido mayor atención. El desempeño manufacturero es vital para explicar la centralidad económica del Bajío, lo que constituye una continuidad histórica cuyas características específicas conviene dilucidar. A partir de algunas estimaciones se muestra la composición de las manufacturas en Guanajuato y la relevancia de la actividad textil a mediados del siglo XIX. Se busca identificar elementos que contribuyan a una explicación del desarrollo fabril del Bajío, con base en algunas experiencias concretas del ramo textil.
The Genetic Basis of Decathlon Performance: An Exploratory Study
Authors: Remmel Liina , Ben-Zaken Sigal , Meckel Yoav , Nemet Dan , Eliakim Alon , Jürimäe Jaak
Published: July 2023

Remmel, L, Ben-Zaken, S, Meckel, Y, Nemet, D, Eliakim, A, and Jürimäe, J. The genetic basis of decathlon performance: an exploratory study. J Strength Cond Res 37(8): 1660–1666, 2023—Decathlon is a combined track and field competition consisting of 10 different events, most of which are anaerobic-type events. Therefore, it is assumed that an anaerobic genetic predisposition might be prevalent among decathletes. Yet, to the best of our knowledge, the genetic basis of decathlon performance had not been studied. Therefore, the aim of this study was to assess the prevalence genetic polymorphisms associated with power performance (AGT, rs699, Met235Thr T/C), speed (ACTN3, rs1815739 C1747T), aerobic endurance (PPARD, rs2016520 T294C), and lactate clearance (MCT1, rs1049434 A1470T) among decathletes. One hundred thirty-seven male track and field athletes (51 sprinters and jumpers, 59 long distance runners, and 27 decathletes) participated in the study. Genomic DNA was extracted from buccal epithelial cells. Genotypes were determined using the Taqman allelic discrimination assay. Decathletes had a higher prevalence of the ACTN3 RR genotype, which is associated with speed ability, and a lower prevalence of the PPARD CC genotype, which is associated with endurance performance compared with long-distance runners. Decathletes had a higher prevalence of the AGT CC genotype associated with strength performance and a higher prevalence of the MCT1 TT genotype, which is associated with improved lactate transport compared with both sprinters and jumpers and long-distance runners. The results suggest that a favorable genetic polymorphism for strength-related capability might be advantageous for decathletes, whereas a genetic makeup favoring aerobic performance is not necessary.
The Effects of Strength and Conditioning Interventions on Sprinting Performance in Team Sport Athletes: A Systematic Review and Meta-Analysis
Authors: Murphy Andrew , Burgess Katherine , Hall Andy J. , Aspe Rodrigo R. , Swinton Paul A.
Published: July 2023

Murphy, A, Burgess, K, Hall, AJ, Aspe, RR, and Swinton, PA. The effects of strength and conditioning interventions on sprinting performance in team sport athletes: a systematic review and meta-analysis. J Strength Cond Res 37(8): 1692–1702, 2023—Linear sprinting is a key determinant of athletic performance within team sports. The aims of the review were to quantify and compare the effectiveness of popular strength and conditioning (S&C) training modes to improve sprint performance in team sport athletes, with additional focus on potential moderators and the relationships between improvements in physical factors (e.g., strength, power, and jump performance) and improvements in sprint performance. Inclusion was restricted to resistance, plyometric, sprint, and combined training interventions comprising team sport athletes. Multilevel, Bayesian’s meta-analysis and meta-regression models conducted with standardized mean difference effect sizes were used to investigate training modes and potential moderators. Weighted regression models conducted on shrunken estimates from initial Bayesian’s meta-analyses were used to quantify relationships between improvements in physical factors and sprint performance. Certainty of evidence was assessed using the grading of recommendations assessment development and evaluation (GRADE) approach. Similar improvements in sprint performance were obtained across training modes, with some evidence of the largest effects with resistance training (

= 0.55 [95% credible interval [CrI]: 0.36–0.78; very low certainty]). A strong moderating effect of training intensity was identified across all training modes with evidence of greater improvements in sprint performance with high-intensity training (

= 0.17 [95% CrI: 0.01–0.33; very low certainty]). Strong positive relationships were identified between improvements in all physical factors and sprint performance (

= 0.56 [95% CrI: 0.36–0.77; low certainty],

= 0.80 [95% CrI: 0.50–1.0; low certainty],

= 0.78 [95% CrI: 0.57–0.97; low certainty]). The findings indicate that focus on developing speed in team sport athletes should be placed on S&C training with high intensities, including the use of resisted sprint training.
Gravidez de substituição: ressignificando o adoecimento por câncer / Surrogacy: new meaning for cancer disease
Authors: Mergen Natália Taís , Cabral Fernanda Beheregaray , Hildebrandt Leila Mariza , Da Silveira Andressa , Oliveira Girardon-Perlini Nara Marilene , Van der Sand Isabel Cristina Pacheco
Published: July 2023

Objetivo: conhecer a vivência da família ampliada quando um de seus membros/casal decide pela gravidez de substituição após diagnóstico e tratamento de câncer ginecológico. Método: estudo de caso de abordagem qualitativa. Participou uma família ampliada de sete pessoas domiciliadas em dois municípios. Os dados foram produzidos pela narrativa de vivências, obtidos por entrevista aberta e submetidos à análise temática. Resultados: a primeira categoria refere-se à união da família para apoiar a familiar que enfrentava um diagnóstico de câncer ginecológico. A segunda discorre sobre sentimentos que representaram o amálgama familiar diante do adoecimento e da decisão pela gravidez de substituição, vitais ao amparo da gestante substituta e mãe biológica. Conclusões: a gravidez de substituição possibilitou que a família ressignificasse o adoecimento e o sentido de família, mobilizada pela solidariedade, altruísmo, empatia e fé.
Excitation and Inhibition Delays within a Feedforward Inhibitory Pathway Modulate Cerebellar Purkinje Cell Output in Mice
Authors: Binda Francesca , Spaeth Ludovic , Kumar Arvind , Isope Philippe
Published: July 2023

The cerebellar cortex computes sensorimotor information from many brain areas through a feedforward inhibitory (FFI) microcircuit between the input stage, the granule cell (GC) layer, and the output stage, the Purkinje cells (PCs). Although in other brain areas FFI underlies a precise excitation versus inhibition temporal correlation, recent findings in the cerebellum highlighted more complex behaviors at GC–molecular layer interneuron (MLI)–PC pathway. To dissect the temporal organization of this cerebellar FFI pathway, we combinedex vivo patch-clamp recordings of PCs in male mice with a viral-based strategy to express Channelrhodopsin2 in a subset of mossy fibers (MFs), the major excitatory inputs to GCs. We show that although light-mediated MF activation elicited pairs of excitatory and inhibitory postsynaptic currents in PCs, excitation (E) from GCs and inhibition (I) from MLIs reached PCs with a wide range of different temporal delays. However, when GCs were directly stimulated, a low variability in E/I delays was observed. Our results demonstrate that in many recordings MF stimulation recruited different groups of GCs that trigger E and/or I, and expanded PC temporal synaptic integration. Finally, using a computational model of the FFI pathway, we showed that this temporal expansion could strongly influence how PCs integrate GC inputs. Our findings show that specific E/I delays may help PCs encoding specific MF inputs.

SIGNIFICANCE STATEMENTSensorimotor information is conveyed to the cerebellar cortex by mossy fibers. Mossy fiber inputs activate granule cells that excite molecular interneurons and Purkinje cells, the sole output of the cerebellar cortex, leading to a sequence of synaptic excitation and inhibition in Purkinje cells, thus defining a feedforward inhibitory pathway. Using electrophysiological recordings, optogenetic stimulation, and mathematical modeling, we demonstrated that different groups of granule cells can elicit synaptic excitation and inhibition with various latencies onto Purkinje cells. This temporal variability controls how granule cells influence Purkinje cell discharge and may support temporal coding in the cerebellar cortex.
microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes
Authors: Sako Hiroaki , Youssef Mohieldin , Elisseeva Olga , Akimoto Takayuki , Suzuki Katsuhiko , Ushida Takashi , Yamamoto Tadashi
Published: July 2023

Slower translation rates reduce protein misfolding. Such reductions in speed can be mediated by the presence of non‐optimal codons, which allow time for proper folding to occur. Although this phenomenon is conserved from bacteria to humans, it is not known whether there are additional eukaryote‐specific mechanisms which act in the same way. MicroRNAs (miRNAs), not present in prokaryotes, target both coding sequences (CDS) and 3′ untranslated regions (UTR). Given their low suppressive efficiency, it has been unclear why miRNAs are equally likely to bind to a CDS. Here, we show that miRNAs transiently stall translating ribosomes, preventing protein misfolding with little negative effect on protein abundance. We first analyzed ribosome profiles and miRNA binding sites to examine whether miRNAs stall ribosomes. Furthermore, either global or specific miRNA deficiency accelerated ribosomes and induced aggregation of a misfolding‐prone polypeptide reporter. These defects were rescued by slowing ribosomes using non‐cleaving shRNAs as miRNA mimics. We finally show that proinsulin misfolding, associated with type II diabetes, was resolved by non‐cleaving shRNAs. Our findings provide a eukaryote‐specific mechanism of co‐translational protein folding and a previously unknown mechanism of action to target protein misfolding diseases.
Functional status and quality of life in young adults with cerebral palsy
Authors: Kapruz Savaş , Yilmaz Ramazan , Izki Alparslan A. , Akkurt Mustafa F. , Akkurt Burcu , Akkurt Halil E. , Albayrak Gezer İlknur , Yilmaz Halim
Published: July 2023

Objective: To identify the sociodemographic characteristics, pain level, quality of life, functional state, mobility, and depression level in adults with cerebral palsy (CP). Material and methods. Our study included 78 adults with CP (mean age 24.75±7.66 years, 40.5% males) and 79 control subjects (mean age 26.74±6.72 years, 38.5% males). The quality of life, depression, and mobility of all participants were evaluated. In addition, functional status, functional independence and activity level were evaluated in the adult CP group. The depression level was determined by the Beck Depression Inventory (BDI), the mobility level was identified via Rivermead Mobility Index (RMI), and the quality of life was evaluated by the Short Form-36 (SF-36). The functional level of adults with CP was assessed with Gross Motor Function Classification System. Functional independence and activity level were evaluated using the Functional Independence Measure scale (FIM). Pain level was assessed with Visual Analogue Scale (VAS). Results. The patient and control groups were statistically different in terms of their educational status, marital status, duration of marriage, employment status, and monthly income (p<0.05). SF-36 summary scale scores and subgroup scores, as well as RMI and FIM scores of CP patients, were lower than in the control group. In addition, we revealed a statistically significant positive correlation of FIM scores with SF-36 physical and mental components, along with a statistically significant negative correlation of VAS with FIM, and of FIM with GMFCS: p<0.001, r= 0.450; p=0.013, ^0.279; p=0.022, r= -0.257; p<0.001, r= -0.741, respectively. Conclusion. We established that the quality of life, along with the mobility and functional levels, were lower in young adults with CP than in the control group, while the depression and pain levels were higher vs. control group. Hence, pain, depression, mobility, functional level, and quality of life should be assessed during the follow-up of adult patients with CP
Professor Vladimir M. Popkov (to the 65th birth anniversary)
Authors: Ponukalin Andrey N. , Rossolovsky Anton N. , Fomkin Roman N. , Maslyakova Galina N. , Bucharskaya Alla B. , Fedonnikov Alexander S. , Eremin Andrey V.
Published: July 2023

The article presents the creative biography of the famous doctor, scientist, teacher, rector and president of the Saratov State Medical University n. a. V. I. Razumovsky — one of the oldest and most advanced medical universities in Russia, Head of the Department of Urology and Director of the Research Institute of Fundamental and Clinical Uronephrology of One-Name University, a worthy successor of the Saratov Urological School, a member of the Presidium of the Russian Society of Urologists, Doctor of Medical Sciences, Professor, Honored Doctor of the Russian Federation Vladimir Mikhailovich Popkov.
“Navigating The Storm”: Peran Grit sebagai Penghambat Stres Mahasiswa di Masa Pandemi
Authors: Amawidyati Sukma Adi Galuh , Rizki Binta Mu’tiya , Ulya Laila Listiyana
Published: July 2023

Pandemi COVID-19 memunculkan tantangan global terhadap kesejahteraan, baik secara fisik maupun psikologis. Berbagai hasil penelitian menunjukkan bahwa dampak negatif yang muncul selama pandemi adalah permasalahan terkait kesehatan mental, salah satunya adalah stres. Salah satu faktor protektif yang dapat mempengaruhi stres seseorang adalah grit. Grit memiliki pengaruh kuat untuk menurunkan stres karena merupakan salah satu sumber psikologis yang dapat meningkatkan resiliensi dalam diri. Penelitian ini bertujuan untuk melihat peran grit terhadap stress pada mahasiswa di masa pandemi. Teknik sampling yang digunakan dalam penelitian ini adalah convenience sampling. Responden yang terlibat dalam penelitian ini berjumlah 258 mahasiswa. Instrumen yang digunakan dalam penelitian ini adalah Skala Grit dan sub skala stres pada skala Depression Anxiety Stress Scale (DASS-42). Analisis data dalam penelitian ini dilakukan dengan analisis regresi sederhana menggunakan software statistik open source Jamovi. Hasil penelitian menunjukkan bahwa grit memiliki peran negatif terhadap stres (F=8,14; p0,05). Grit memberikan sumbangan efektif 6,7% terhadap stres.  The COVID-19 pandemic creates global challenges to well-being, both physically and psychologically. Various research results show that the negative impacts that emerged during the pandemic were problems related to mental health, one of which was stress. One of the protective factors that can affect a person's stress is grit. Grit has a strong influence on reducing stress because it is a psychological source that can increase self-resilience. This study aims to see the role of grit in stress on students during a pandemic. We use convenience sampling in this research. Respondents involved in this study amounted to 258 students. The instruments used in this study were the grit scale and the stress sub-scale on the Depression Anxiety Stress Scale (DASS-42). Data analysis in this study was carried out by simple regression analysis using the open-source statistical software Jamovi. The results showed that grit negatively affected stress (F=8.14; p0.05). Grit's contribution to stress is 6.7%.
Peran Stres yang Dialami Orang Tua dan Welas Diri terhadap Kepuasan Hidup Selama Pandemi Covid-19
Authors: Sutanto Sandra Handayani , Sugianto Dicky , Anna Jessica Amelia
Published: July 2023

Pandemi Covid-19 dan perubahan yang menyertainya mendatangkan dampak bagi semua orang, termasuk orang tua yang diharuskan beradaptasi dengan metode pembelajaran baru dan kebiasaan baru. Proses beradaptasi ini mendatangkan stres bagi orang tua, ditandai dengan keluhan yang cukup banyak, dan jika tidak ditangani dengan coping yang tepat akan mendatangkan burnout, dan menurunkan kepuasan hidup orang tua. Welas diri merupakan salah satu cara untuk menangani stres sehingga membuat kepuasan hidup tetap terjaga. Penelitian ini menggunakan metode korelasional yang bertujuan secara empiris melihat pengaruh stres yang dialami oleh orang tua dan welas diri yang dimiliki terhadap kepuasan hidup selama masa pandemi. Alat ukur Parenting Stress Scale, Skala Welas Diri dan Satisfaction with Life Scale yang telah diadaptasi digunakan dalam penelitian ini dengan subjek penelitian sebanyak 154 orang tua yang didapat dengan metode convenience sampling. Teknik analisis yang digunakan adalah analisis regresi berganda dengan hipotesa alternatif diterima sehingga hasil penelitian  menunjukkan bahwa stres yang dialami oleh orang tua bersama-sama dengan welas diri memengaruhi kepuasan hidup sebesar 3.8%. Hasil dari penelitian ini dapat memberikan rekomendasi kepada orang tua bagaimana menangani stres serta menjaga kepuasan hidup selama pandemi. The Covid-19 pandemic and all the changes have an impact on everyone, including parents who are required to adapt to new learning methods and new habits. This adaptation process brings stress to parents, characterized by quite a lot of complaints, and if not handled with the right coping, it will cause burnout, and reduce parental life satisfaction. Self-compassion is a way to cope with stress to maintain life satisfaction. This study employs correlational design with the aim of empirically looking at the influence of stress experienced by parents and their self-compassion on life satisfaction during the pandemic. Parenting Stress Scale, Self-Compassion Scale and Satisfaction with Life Scale which have been adapted are used in this study with 154 parents as research subjects obtained by convenience sampling method. The results of the study, using multiple regression analysis with alternatif hypothesis received so it showed that the stress experienced by parents together with self-compassion affected life satisfaction 3.8%. Results suggest recommendation to parents on how to manage stress and improve life satisfaction within the pandemic.
Perilaku Phone Snubbing (Phubbing) pada Generasi X, Y, dan Z
Authors: Najah Miftahun , Fadilah Amaliah Fadilah , Rachmi Ivany , Iskandar Iskandar
Published: July 2023

Perkembangan teknologi informasi dan komunikasi selain memberikan dampak positif juga mengarahkan pada konsekuensi negatif, yaitu phubbing. Phubbing merupakan perilaku mengabaikan lawan bicara dengan berfokus pada ponsel. Perbedaan generasi digital dapat mengarahkan pada perbedaan tingkat perilaku phubbing. Penelitian ini bertujuan untuk mengidentifikasi perbedaan perilaku phubbing pada generasi X, Y dan Z. Penelitian ini melibatkan 250 partisipan. Proses perekrutan partisipan menggunakan teknik non-probability purposive sampling. Peneliti menggunakan adaptasi alat ukur generic scale of phubbing. Uji hipotesis dilakukan melalui teknik analisis data Anova One Way. Hasil penelitian menunjukkan bahwa hipotesis diterima, yaitu terdapat perbedaan perilaku phubbing yang signifikan pada generasi X, Y, dan Z (F [2,247] = 4.70, p .05). Hasil ini mengindikasikan bahwa phubbing dipengaruhi oleh faktor usia atau generasi digital dan penggunaan ponsel pintar.  The development of information and communication technology does not only bring positive impact but also the negative one, namely phubbing. Phubbing is behavior of ignoring other person by focusing on phone. The digital generation difference can lead to different levels of phubbing. This research aims to identify the differences in phubbing behavior of generations X, Y and Z. 250 phone users from various digital generation participated in this research. We used non probability purposive sampling to recruit the participant. In this study, phone snubbing was measured with adapted version of generic scale of phubbing. We carried out One Way Anova data analysis technique to test the hypothesis. The result showed that the hypothesis was accepted, there were significant difference in phubbing behavior between generations X, Y and Z  (F [2,247] = 4.70, p 0.05). The results indicate that phubbing behavior is influenced by digital generation and smartphone use factor.
Corti connesse: Identità e rappresentazione, cultura materiale e immateriale in Sicilia tra XVI e XVII Secolo.
Authors: D'Agata Silvia
Published: July 2023

Questo lavoro si propone di analizzare le connessioni tra corti che si realizzavano mediante la condivisione di letterati, artisti e maestranze specializzate. Un punto di vista capace di mostrare le reti che legavano una Sicilia in cui numerose erano le piccole corti aristocratiche, microcosmi politici di gestione dei territori in cui si inscrissero. Tra XVI e XVII secolo, nell’isola, vi fu un alto livello di cultura prodotta e consumata, arricchita dai rapporti che l’élite intratteneva con Madrid e che diede il via ad un processo di circolarità culturale tra il cuore della monarchia e le sue province, da leggere anche attraverso gli oggetti del gusto, realizzati da sarti che spesso parlavano spagnolo. Altre volte sono gli inventari a definire non solo la circolarità degli uomini, ma uno spagnolismo dei gusti. La cultura quindi assume il significato di elemento di creazione di un terreno di sintesi, di abbattimento di frontiere, mediante la creazione di un’élite sempre più transnazionale.
La importancia del "buen casar". Un acercamiento a la política matrimonial de las camaristas de Palacio en tiempos de Carlos III
Authors: Peña Ramos Jon
Published: July 2023

El presente trabajo pretende dar a conocer la política matrimonial de las camaristas de Palacio que casaron durante el reinado de Carlos III (1759-1788). Estas jóvenes solteras de condición noble formaban parte del círculo femenino palatino y sus puestos cortesanos les granjearon multitud de posibilidades y oportunidades. Entre ellas la de desposar a un contrayente de renombre. Partiendo de este conjunto pretendemos analizar, por un lado, el perfil de las camaristas que tomaron estado y el de sus futuros maridos. El estudio prosopográfico de esta cuestión, así como la utilización de casos particulares de la segunda mitad del siglo XVIII, posibilitará atender a otras cuestiones tales como sus contextos familiares o las redes clientelares en las que se insertaban. Todo ello será posible a través del análisis y valoración de los fondos documentales conservados en los archivos nacionales, y particularmente en el Archivo General de Palacio.
El "efecto Lepanto"
Authors: García Hernán David
Published: July 2023

Este trabajo pretende mostrar a través de algunos aspectos significativos que la batalla de Lepanto, lejos de considerarse un enfrentamiento inútil y sin ninguna trascendencia, como ha venido diciendo la historiografía tradicional, tuvo importantes implicaciones.  La nueva historia cultural y el riquísimo panorama de representaciones culturales sobre el hecho que se están estudiando en los últimos años, permite acercarnos a nuevas perspectivas bastante esclarecedoras; así como otros aspectos que nos introducen en el verdadero contexto político global del momento, y también importantes dimensiones prácticas, como el desarrollo de la logística.  Ello nos permite acercarnos, ayudados por algunos documentos originales no conocidos hasta ahora, y más allá de una simple mirada -ventajista- sobre los hechos posteriores, al verdadero sentido de la victoria cristiana.
Barbaro’s Glass Ball and Sokollu Mehmed’s Finesse. Ottoman-Venetian Peace in 1573
Authors: Işıksel Güneş
Published: July 2023

While the naval battle of Lepanto as well as the founding and dissolution of the Holy League has attracted significant scholarly attention, the preparation and ratification of the ensuing peace treaty between Ottoman Empire and Republic of Venice has received relatively little attention. Nonetheless, the three months of lengthy negotiations that culminated in the treaty of capitulations provide a valuable insight into the early modern Ottoman approaches to international negotiations and treaty-making. Sokollu Mehmed Pasha (1565-1579), Grand Vizier of Sultan Selîm II (1566-1574), was the principal protagonist of these negotiations on the Ottoman side. This article focuses on the encounters of the latter with Marcantonio Barbaro, Venetian bailo and François de Noailles, ambassador of King of France Charles IX and aims to provide a new perspective on their bargainings by emphasising the participants’ points of view, achievements and failures, hidden agendas, as well as tactics.
Canciones, trompetas y salvas: una relectura de Lepanto desde el soundscape hispánico
Authors: Escrivá Llorca Ferran
Published: July 2023

La victoria en la batalla naval de Lepanto fue celebrada de forma excepcional en multitud de lugares. A través del paisaje sonoro histórico se plantea una lectura en tres episodios de cómo fueron de importantes estas celebraciones para la Monarquía Hispánica y los personajes implicados, como don Juan de Austria. A partir de las relaciones de sucesos y de la única composición conservada en castellano se ofrece una panorámica dedicada al evento y recreación de cómo sonarían las ciudades de Barcelona, Sevilla y Mesina. A través de estos ejemplos, este acercamiento desde la musicología histórica muestra la importancia de la música y el sonido en la representación del poder y el orden establecido en la Edad Moderna.
Asociación entre el polimorfismo Val66Met del gen BDNF y el desarrollo de disfunción ejecutiva en pacientes con cáncer de mama
Authors: Cortez-Pacheco Renzo , Acosta Oscar , Casavilca-Zambrano Sandro
Published: July 2023

Introducción. La disfunción ejecutiva asociada a quimioterapia es un efecto adverso del tratamiento antineoplásico convencional y afecta a un porcentaje considerable de personas. Se ha reportado que la presencia de ciertos polimorfismos en genes relevantes puede causar una mayor susceptibilidad a padecerlo. Objetivo. Determinar la relación entre el polimorfismo Val66Met (196 G>A) del gen BDNF y el desarrollo de disfunción ejecutiva en mujeres con cáncer de mama tratadas con quimioterapia. Métodos. Se evaluó a 73 pacientes mujeres con con cáncer de mama antes y después de la quimioterapia, para determinar disfunción ejecutiva. La evaluación fue realizada con la prueba INECO Frontal Screening (IFS). Se determinó el genotipo (GG=Val/Val, GA=Val/Met y AA=Met/Met) por PCR y secuenciamiento del gen BDNF. El análisis de asociación se realizó mediante el cálculo del odds ratio (OR). Resultados. El 13,7% (n = 10) de pacientes presentó el alelo A (GA y AA), además obtuvieron puntajes significativamente menores de la prueba IFS comparado con las homocigotas GG (p < 0,05). Las pacientes agrupadas según la presencia del alelo A (GA/AA vs GG) y comparadas según presencia o ausencia de la disfunción ejecutiva, no mostraron diferencias significativas (OR = 1,86; IC 95%: 0,49 a 7,14; p = 0,483). Conclusiones. No se encontró asociación significativa entre el polimorfismo Val66Met (196G>A) del gen BDNF y el desarrollo de disfunción ejecutiva en pacientes con cáncer de mama tratadas con quimioterapia; sin embargo, las portadoras del alelo A (Met) presentaron puntajes menores en la evaluación cognitiva.
Infarto pulmonar cavitado en mujer con lupus eritematoso sistémico asociado a síndrome antifosfolípido
Authors: Liñán Ponce Freddy , Leiva Goicochea Juan , Miranda Damián Marlong , Leiva Rodriguez Carlos , Sevilla Rodríguez David , Gross Melo Fernando
Published: July 2023

Tanto lupus eritematoso sistémico como síndrome antifosfolípido son enfermedades autoinmunes con potencial tromboembólico, sobre todo por la presencia de anticuerpos trombogénicos. El pulmón es un lugar común donde suele asentarse un trombo y generar una tromboembolia, a veces con posterior infarto y cavitación. Existen pocos estudios que informen un infarto pulmonar cavitado en un paciente con lupus asociado a síndrome antifosfolípido. Presentamos el caso de una mujer de 24 años con síntomas generales y lesión pulmonar derecha cavitada. Fue tratada inicialmente como infección tuberculosa y fúngica. La analítica y las imágenes orientaron y diagnosticaron lupus asociado a síndrome antifosfolípido, complicado con tromboembolismo pulmonar que luego pasó a cavitarse. La paciente mejoró considerablemente con anticoagulantes, corticoides y ciclofosfamida.
Consanguinidad no declarada en pacientes peruanos con trastorno del neurodesarrollo detectada a través de micromatrices
Authors: Abarca Barriga Hugo , Merino Rosas Renzo
Published: July 2023

Introducción. La consanguinidad es la unión entre personas que comparten un ancestro en común, y cuya descendencia presenta un mayor riesgo de aparición de enfermedades autosómicas recesivas, manifestándose en algunos pacientes como trastornos del neurodesarrollo. Objetivos. Describir la consanguinidad parental no declarada en pacientes menores de 18 años con trastornos del neurodesarrollo, descubierta mediante el análisis cromosómico por micromatrices. Métodos. Se realizó el análisis cromosómico por micromatrices a 967 pacientes con trastorno del neurodesarrollo entre 2016 y 2021. Fueron seleccionados los pacientes con regiones de homocigosidad (ROH) con un valor superior a 0,5%. Resultados. Se evaluó a 288 pacientes, el 58,3% fueron varones y el 29,8% presentó una ROH mayor o igual a 0,5%. Se encontró que el 25,9% y el 0,83% de los pacientes tenían padres con un quinto y primer grado de consanguinidad no declarada, respectivamente. Los departamentos con mayor frecuencia relativa de consanguinidad no declarada por cada 10 000 habitantes fueron Huancavelica, Cajamarca y Apurímac. Conclusión. En Perú, existen regiones donde se evidencia uniones parentales consanguíneas, el cual es un factor de riesgo alto para la aparición de enfermedades recesivas autosómicas en su descendencia, como los trastornos del neurodesarrollo.
Características clínicas y epidemiológicas de la viruela del mono en una serie de casos tratados en un establecimiento de salud del Perú
Authors: Briceño Monica
Published: July 2023

La infección por el virus de la viruela del mono es una zoonosis producida por un virus tipo DNA, del género orthopoxvirus. En este reporte se describe una serie de 12 casos cuya media de edad fue 36 años, con antecedente de sexo entre hombres en el 66%; previo al inicio de los síntomas el 50% manifestó haber tenido relaciones sexuales con desconocido. Los síntomas prodrómicos se presentaron en el 90%, entre 1 y 4 días caracterizados por fiebre, cefalea, mialgia. Las lesiones dérmicas fueron pústulas-vesículas, pápulas, costras localizadas principalmente en extremidades, cara-tórax y genitales. Todos los casos tuvieron una evolución favorable.
Aneurisma de arteria iliaca: una causa de dolor abdominal agudo de alto riesgo
Authors: Ayala Garcia Ricardo Jonathan
Published: July 2023

El dolor abdominal de alto riesgo es una condición común en los servicios de emergencia y está asociado a una alta morbilidad y mortalidad, si no se diagnostica y trata de manera rápida y precisa. Un hombre con síntomas de cólico nefrítico se presentó en emergencia con dolor abdominal intenso y deterioro clínico. Después de una tomografía, se encontró una imagen aneurismática en la arteria iliaca común primitiva izquierda. El paciente fue trasladado a sala de operaciones para una reparación quirúrgica, pero falleció. El dolor abdominal de alto riesgo requiere un abordaje diagnóstico integral y tratamiento individualizado para prevenir complicaciones graves. El aneurisma de la arteria iliaca complicado es una causa potencialmente grave de dolor abdominal en hombres fumadores de edad avanzada con antecedentes de hipertensión y aterosclerosis.
Réplica a: Otros factores a considerar y precisiones sobre el artículo “Frecuencia elevada de casos de dengue grave durante la epidemia por el linaje II del DENV-2 americano/asiático en el Perú”
Authors: Durand S.
Published: July 2023

Sr. Editor,

Hemos leído atentamente los comentarios al artículo titulado “Frecuencia elevada de dengue grave durante la epidemia por el Linaje II del DENV-2 americano/asiático en el Perú” (1), publicados en su prestigiosa revista. Agradecemos el interés por el mismo y hacemos algunas precisiones.
Calidad de los efluentes de las Plantas de Tratamiento de Aguas Residuales domésticas de Piura
Authors: Alcántara Alfaro Carlos Alberto , De la Cruz Gutierrez Dallin , Julián Soto Adan Schneider , Mera Villalobos Cintya Melissa , Montoya Castillo Mariana Lisbeth , Sanchez Huayanay Mayumi Rubi , Malca Casavilca Nora Rosa Concepción
Published: July 2023

La presente investigación tuvo por objetivo evaluar la calidad de los efluentes de las Plantas de Tratamiento de Aguas Residuales (PTAR) domésticas del departamento de Piura en el periodo 2019 - 2021. Se hizo uso de una metodología cuantitativa y se analizó la información de los datos estadísticos procedentes de los informes anuales de la Evaluación de la Calidad de los efluentes de los Prestadores de Servicios de Saneamiento, mediante la cual, se logró evaluar la calidad de los efluentes de las PTAR en los años de interés. Los resultados obtenidos indicaron un mayor nivel de incumplimiento en los siguientes parámetros: Coliformes Termotolerantes (93,10%), Sólidos Suspendidos Totales (41,38%), Demanda Química de Oxígeno (79,31%), Demanda Biológica de Oxígeno (65,52%), Aceites y Grasas (10,34%), pH (6,90%) y Temperatura (0,00%). En conclusión, se evidenció que los valores no cumplen con los Límites Máximos Permisibles establecidos, sobrepasando un porcentaje mayor al 40% en 4 de los 7 parámetros de evaluación.
Deforestación en Madre de Dios: Un infierno para la biodiversidad
Authors: Alva-Avila Rosmel Omar , Falcon Briones Isely Dysanda , Hinsbi-Aguirre Nina Angélica Lucía , Ramírez-Vega Clever Andre , Saravia-Inocencio Jackelyn Flor , Valverde-Ashcalla Silvana Lujan , Malca-Casavilca Nora Rosa Concepción
Published: July 2023

Uno de los problemas más graves en la Amazonía peruana es la deforestación, que tiene su mayor expresión en el departamento de Madre de Dios, razón por la cual, el objetivo de este artículo es informar sobre el impacto que causa la deforestación en la biodiversidad de este departamento. Debido a la minería y a la agricultura se ha perdido el bosque en esta zona, se han reducido las especies de mamíferos y aves. En esta investigación, se utilizó una metodología de tipo cualitativa. Se hizo una revisión sistemática y se analizaron estudios de investigaciones ya existentes, con lo que finalmente se obtuvieron datos estadísticos sobre la progresión de la deforestación en Madre de Dios del 2002-2021 y el estado de conservación actual de mamíferos y aves. Como resultado, se evidencia un aumento significativo de la deforestación entre 1999-2021. Asimismo, hay un impacto negativo en la biodiversidad, específicamente en aves y mamíferos. Es un problema que se debe solucionar, impulsar una minería y agricultura sostenible es el camino para mitigar los impactos ambientales en la Amazonía.
Herramientas de Gestión de la Responsabilidad Social en Sudamérica
Authors: Del Aguila Daisy , Córdova Freddy , Díaz Cristopher , Sanchez Carolina , Solís Tomy , Zúñiga Juan , Torres Guerra Jesús Alberto
Published: July 2023

La responsabilidad social es un tema que ha ido tomando importancia con el pasar de los años, pese a ello, en muchos países sudamericanos, aún se desconoce este tema, lo que implica una aplicación incipiente a nivel social, ambiental, comunidad o gobierno. En cuanto a las herramientas de gestión, muchos de estos países están logrando que, en los últimos años, gran parte de sus empresas las implementen. Para cumplir los objetivos del presente trabajo se revisó información bibliográfica, tomando referencias de la aplicación de estas herramientas de gestión en países como Perú, Ecuador, Bolivia y Chile. Se realizó una comparación de estos países para ver su evolución. Para el caso del Perú se realizó una encuesta mixta usando la escala Likert y preguntas abiertas, dirigido a empresas de diferentes rubros. Los resultados muestran que aún no es muy estable este tema en las empresas de estos países, pero se está buscando las maneras de llegar a establecerlos mediante instituciones, universidades y usando las herramientas de responsabilidad social.