bluuebunny/crossref_metadata_2025 huggingface dataset:
THE RED SEQUENCE AT BIRTH IN THE GALAXY CLUSTER Cl J1449+0856 AT z = 2
Authors: Strazzullo V. , Daddi E. , Gobat R. , Valentino F. , Pannella M. , Dickinson M. , Renzini A. , Brammer G. , Onodera M. , Finoguenov A. , Cimatti A. , Carollo C. M. , Arimoto N.
Published: December 2016

We use  Hubble Space Telescope/WFC3 imaging to study the red population in the IR-selected, X-ray detected, low-mass cluster Cl J1449+0856 at z = 2, one of the few bona fide established clusters discovered at this redshift, and likely a typical progenitor of an average massive cluster today. This study explores the presence and significance of an early red sequence in the core of this structure, investigating the nature of red-sequence galaxies, highlighting environmental effects on cluster galaxy populations at high redshift, and at the same time underlining similarities and differences with other distant dense environments. Our results suggest that the red population in the core of Cl J1449+0856 is made of a mixture of quiescent and dusty star-forming galaxies, with a seedling of the future red sequence already growing in the very central cluster region, and already characterizing the inner cluster core with respect to lower-density environments. On the other hand, the color–magnitude diagram of this cluster is definitely different from that of lower-redshift z ≲ 1 clusters, as well as of some rare particularly evolved massive clusters at similar redshift, and it is suggestive of a transition phase between active star formation and passive evolution occurring in the protocluster and established lower-redshift cluster regimes.
EQUILIBRIUM ROTATION STATES OF DOUBLY SYNCHRONOUS BINARY ASTEROIDS
Authors: Golubov Oleksiy , Scheeres Daniel J.
Published: December 2016

A doubly synchronous binary asteroid simultaneously experiences YORP and BYORP, the former being independent of the radius of the orbit, while the latter is linearly dependent on the radius. In many systems, YORP and BYORP can compensate each other at some radius, causing an equilibrium state, to which other orbits converge in the course of their evolution. We derive the mathematical formalism of such equilibria in terms of dimensionless YORP and BYORP coefficients. We compute YORP and BYORP coefficients for a set of photometric and radar shape models, and find equilibria to be relatively common, with a probability of 4% to roughly 10% depending on how the mass is distributed within the binary.
Caius Munatius Faustus, l’ Augustalis et paganus pompéien aux deux tombeaux
Authors: Rossi Lucia
Published: December 2016

Le présent article développe l’étude des monuments épigraphiques de l’affranchi C. Munatius Faustus, conservés dans deux nécropoles pompéiennes et dans le désert Oriental égyptien. Après un examen approfondi des informations textuelles, notamment du vocabulaire et des formulaires, l’auteur étudie les spécificités matérielles des monuments épigraphiques, notamment l’iconographie et le contexte topographique. Ces éléments permettent en effet de reconstituer les pratiques sociales de certains acteurs du corps social et les processus de leur codification en un ensemble de savoirs sociaux.
L’ identité professionnelle et l’ expression du métier dans l’ épigraphie portuaire occidentale : différents niveaux de codification
Authors: Rougier Hélène
Published: December 2016

À travers l’étude d’inscriptions relatives aux métiers portuaires issues de six cités, l’article vise à déceler dans les noms de métiers les traces d’identités professionnelles. Ces dernières reposent sur des signes, des « codes » de reconnaissance établis par les professionnels eux-mêmes ou bien par d’autres types d’acteurs, comme les collèges ou les autorités publiques. Il s’agit de tenter de saisir la nature de ces signes et l’influence qu’ils peuvent avoir au sein du milieu professionnel.
Personajes foráneos en la epigrafía de las ánforas Pascual 1 y Oberaden 74
Authors: Járrega Domínguez Ramón
Published: December 2016

Dans cet article, on étudie l’apparition de nouveaux types d’amphores vinaires (Pascual 1 et Oberaden 74) sur la côte est de l’Hispania Citerior et leurs relations avec le changement de régime occasionné par l’arrivée au pouvoir d’Auguste. D’autre part, l’épigraphie amphorique nous aide à étudier la présence de propriétaires terriens venus d’Italie et de Gaule cisalpine ; la découverte de différentes marques faisant références à des Iulii , peut-être affranchis impériaux, sert à envisager la présence possible de propriétés impériales dans la région ou, en tout cas, de la présence à cet endroit d’intérêts impériaux qui pouvaient être gérés par ces affranchis.
S'exprimer et se faire comprendre
Authors: Janner-Raimondi Martine
Published: December 2016

Mener un entretien de recherche ne saurait éviter au chercheur de s’interroger sur la place et le rôle accordés à l’enquêté, d’autant plus lorsque la communication est entravée. La réflexion philosophique sur l’éthique conduit le chercheur qui mène un entretien à prendre en considération le cadre dans lequel il établit sa relation avec autrui, mais également la valeur principielle au nom de laquelle il est amené à réguler son intervention. Si le respect de la personne humaine constitue une valeur centrale, elle ne saurait occulter sa singularité. Dès lors se pose au chercheur la question de la responsabilité, l’invitant à se montrer prudent dans l’usage des notions de contrat et de consentement mutuel. En outre, la recherche elle-même requiert des principes éthiques pour s’efforcer de chercher en vérité. Enfin, la préoccupation éthique n’invite-t-elle pas à évaluer de façon récurrente, non seulement la posture du chercheur lors de l’entretien, mais aussi ses « stratégies » ainsi que la portée et la pertinence de ses questions, de ses relances et de ses reformulations dans le but de recueillir le point de vue d’autrui en première personne, le faisant advenir comme sujet autonome.
S'exprimer et se faire comprendre
Authors: Bedoin Diane , Lantz Elise , Marcellini Anne
Published: December 2016

Ce chapitre traite de la conduite de l’entretien de recherche mené auprès de sujets enquêtés présentant des troubles de l’expression en croisant des expériences d’entretiens semi-directifs menés auprès d’enquêtés sourds et d’entretiens biographiques réalisés avec des personnes ayant une infirmité motrice cérébrale ( imc ). Il vise d’abord à identifier les obstacles à la communication qui peuvent être créés, ou au contraire annulés selon le cadre d’entretien adopté : en quoi la situation d’entretien peut-elle être « handicapante » ? Il s’agit ensuite de proposer des modalités supplétives permettant de favoriser la libre expression des sujets enquêtés : comment créer les conditions de possibilité d’un entretien ? La préparation de l’entretien, les modalités relationnelles et communicationnelles, les outils utilisés, l’attitude du chercheur seront analysés.
S'exprimer et se faire comprendre
Authors: Midelet Julia , Scelles Régine
Published: December 2016

Atteints par une déficience intellectuelle ou touchés par des troubles des fonctions cognitives qui affectent la communication de leur pensée envers autrui, adultes ou adolescents peuvent néanmoins participer à des entretiens proposés par les chercheurs. De nombreuses conditions sont à réunir, comme le souligne la revue de littérature proposée ; il s’agit de soulever, au travers de ce chapitre, la préparation nécessaire en amont de l’entretien et l’organisation de la scène d’échange. Une connaissance des besoins spécifiques de la personne rencontrée permettra d’identifier la pertinence de la présence d’un tiers, l’image renvoyée par le chercheur ou encore les modalités de présentation d’un document permettant de parler de consentement éclairé. La scène de l’entretien mérite aussi que l’on s’y intéresse au sens où la conduite et le rythme impulsés peuvent révéler un certain nombre d’obstacles qu’il convient d’identifier pour tenter de les dépasser.
S'exprimer et se faire comprendre
Authors: Mellier Daniel , Sorin Anne-Laure , Chanoni Émilie
Published: December 2016

L’utilisation de la photographie commentée pour soutenir et motiver l’expression de l’enfant a été expérimentée dans plusieurs domaines de recherche comme la santé ou l’éducation. Nous proposons une réflexion sur cette technique d’entretien avec de jeunes enfants puis rendons compte d’une étude sur les représentations du bien-être à l’école maternelle. Des enfants âgés de 5 ans ont photographié des éléments qu’ils apprécient ou n’aiment pas dans l’école. Ils répondent pour eux ou à la place d’un enfant handicapé de leur classe. Les résultats indiquent d’abord que les enfants sont en mesure d’identifier ce qu’ils apprécient ou non et qu’ils distinguent leur point de vue de celui d’un autre enfant. Ils montrent aussi que leurs réponses concernant l’enfant handicapé coïncident avec celles de cet enfant à la fois dans le choix des photos et dans les arguments développés pour justifier ces choix. L’entretien à partir de photographies prises par les enfants est utilisable pour examiner leur représentation du handicap.
S'exprimer et se faire comprendre
Authors: Souriau Jacques
Published: December 2016

Le recueil des attentes de personnes présentant des déficiences complexes constitue une difficulté habituellement contournée par le recours à des tiers détenteurs de compétence juridique ou technique. On peut cependant concevoir des conditions permettant l’établissement d’un dialogue direct. C’est ainsi qu’une longue pratique des personnes présentant une surdicécité congénitale a permis de construire une approche s’appuyant sur une épistémologie associant approche de seconde personne, dialogisme et narrativité de l’esprit et sur des outils sémiotiques capables de mieux saisir le sens d’expressions peu élaborées. Par ailleurs, une méthodologie d’entretien mise en œuvre dans le cadre d’une recherche-action sur le recueil des attentes des personnes en situation de handicap complexe permet d’énoncer des conditions qui rendent possible un entretien direct.
S'exprimer et se faire comprendre
Authors: Bedoin Diane , Scelles Régine
Published: December 2016

À partir de deux populations différentes – déficients intellectuels et sourds sans troubles associés – et de deux ancrages disciplinaires distincts – l’un en psychologie, l’autre en sociologie –, ce chapitre traite des spécificités de l’analyse des entretiens de recherche réalisés avec ces types de public. Il s’agit de présenter et de discuter des moyens dont dispose le chercheur pour analyser le contenu des discours recueillis auprès de ces sujets enquêtés qui ont parfois eu du mal à s’exprimer, à formuler leur pensée et donc à se faire comprendre au cours de l’entretien. Les trois temps de l’analyse seront successivement abordés : travail de transcription, processus d’interprétation et restitution des données.
Ça n’est pas Lacan
Authors: Bruno Pierre
Published: December 2016

Résumé « Il n’y a de cause qu’après l’émergence du désir », telle est la proposition centrale du séminaire interrompu de novembre 1963, de Lacan, intitulé Les noms du père . Critiquant le mythe freudien de Totem et tabou , Lacan tient qu’il n’y a de Dieu que comme désir.
« Le livre de sable » de Borges : un Autre insaisissable
Authors: Corpelet Dominique
Published: December 2016

Résumé Dans trois de ses contes, « La Bibliothèque totale », « La Bibliothèque de Babel » et « Le livre de sable », J. L. Borges effectue un parcours au terme duquel il peut énoncer que le savoir ne saurait se constituer en totalité close. Avec Russell et le paradoxe des ensembles, l’écrivain donne forme littéraire au mathème de A barré. Il rejoint Lacan qui, dans D’un Autre à l’autre , avec la logique ensembliste, démontre la topologie de A : il est affecté d’une faille.
Du trait à la lettre, du saut du lit à l’amour
Authors: Bakir Aïssa
Published: December 2016

Résumé Trajectoire d’une passe, dans laquelle celle-ci aurait pu s’écrire au pluriel. Singulier du trait faisant signe et matière à la lettre. Le passage de l’analysant à l’analyste, mouvement qui se dépose dans la passe, et dont la musique peut se faire entendre comme un « finale » dans la cure qui se conclut. Tintamarre du trait qui, sans se lisser, se fait lyre et se fait lettre. Lettre qui, sans se forcer, se fait lettre d’amour.
Dante Alighieri ou la poésie amoureuse
Authors: Delécluze Étienne-Jean
Published: December 2016

Résumé Une référence de Lacan.
Análisis longitudinal del Sistema Bibliotecario ecuatoriano
Authors: Álvarez-Muñoz Patricio , Hernández-Domínguez Carmen
Published: December 2016

El éxito de las mejores universidades del mundo se basa en gran medida en el desarrollo de su sistema bibliotecario. Estos sistemas, a su vez, se someten a una dinámica más competitiva con el objetivo de fomentar la generación del conocimiento. Ecuador no está al margen de esta dinámica, y actualmente se encuentra en una evolución integral de su Sistema de Educación Superior, por lo que aquí se muestra un análisis longitudinal del estado actual del sistema universitario de bibliotecas, a partir de una muestra de 25 universidades de las 54 existentes, considerando variables administrativas, tecnológicas, económicas y de servicios, siendo una de las más relevantes el número de documentos por estudiante, la inversión realizada en los accesos a las bases de datos. Además, se explora la manera de cómo las bibliotecas adquieren las bases de datos de información científica, la oferta actual y la inversión del gobierno para proveer las mismas.
Herramientas para la participación ciudadana virtual y su desarrollo en las webs del Sistema Sanitario Público de Andalucía
Authors: Calvo-Calvo Manuel Ángel
Published: December 2016

Los objetivos del estudio fueron identificar herramientas web para materializar la participación virtual ciudadana en salud, averiguar cuales de esas herramientas existen y su grado de desarrollo en las webs del Sistema Sanitario Público de Andalucía. Se identificaron 42 herramientas webs que pueden favorecer la información e interactividad con la ciudadanía y se realizó un estudio descriptivo y transversal, para averiguar qué herramientas participativas aparecen en seis webs del Sistema Sanitario Público de Andalucía. De las herramientas propuestas, 33 estaban presentes en las webs analizadas. La presencia en redes sociales y las aplicaciones Web 2.0 y 1.0 para la información de la ciudadanía, fueron los recursos participativos más desarrollados. Las herramientas 2.0 para la interacción web-usuarios y para la publicación de contenidos creados por los usuarios tuvieron un bajo grado de desarrollo. En las webs estudiadas no se desarrollaron aplicaciones on line para la interacción y colaboración entre usuarios.
La comunicación entre investigadores en Twitter. Una etnografía virtual en el ámbito de las ciencias de la documentación
Authors: Álvarez-Bornstein Belén , Montesi Michela
Published: December 2016

La presente investigación se centra en el estudio de la comunicación científica en Twitter. Pretende conocer y describir el tipo de actividad científica que tiene lugar en esta plataforma, identificando el tipo de información que se difunde y el tipo de actividad que realizan los científicos estudiados.Se analiza una muestra de investigadores del área de ByD que publicaron al menos 3 artículos en la revista EPI en el periodo 2009-2013 y con presencia en Twitter. Para ello empleamos una metodología de tipo cualitativo, utilizando el método de la etnografía virtual, basada en la técnica de la observación no participante. Como principales conclusiones encontramos que los investigadores utilizan Twitter fundamentalmente para una comunicación científica informal, así como para dar a conocer su actividad profesional y difundir sus propias publicaciones científicas, para darles así mayor visibilidad e impacto.
Una herramienta para el seguimiento del profesorado universitario en Entornos Virtuales de Aprendizaje
Authors: Cantabella Magdalena , López-Ayuso Belén , Muñoz Andrés , Caballero Alberto
Published: December 2016

La interacción en Entornos Virtuales de Aprendizaje (EVA) está enfocada principalmente a mejorar la experiencia de uso y resultados académicos del alumnado. Sin embargo, no se debe descuidar la interacción del resto de actores del proceso educativo con estas plataformas, tales como el profesorado y los coordinadores. Este trabajo se centra en la interacción que tiene lugar entre los coordinadores de titulación y un EVA para realizar labores de seguimiento del desempeño del profesorado, especialmente en la modalidad online. Se establecen tres objetivos que guían la metodología seguida: (1) analizar las limitaciones de monitorización del profesorado de los EVA actuales; (2) desarrollar una herramienta de monitorización para superar las limitaciones encontradas; y (3) evaluar empíricamente la herramienta propuesta. Los resultados obtenidos muestran que dicho tipo de herramienta ayuda a los coordinadores a analizar de forma intuitiva y eficiente el estado de las asignaturas de su titulación.
Investigación sobre Bibliotecología, Ciencia de la Información, e Inteligencia Empresarial, a través de las presentaciones a los congresos INFO e IntEmpres: un análisis bibliométrico (2002-2012)
Authors: González-Valiente Carlos Luis
Published: December 2016

En este estudio se describen bibliométricamente los eventos cubanos Congreso Internacional de Información (INFO) y Taller Internacional sobre Inteligencia Empresarial y Gestión del Conocimiento en la Empresa (IntEmpres) durante el periodo 2002-2012. Son aplicados indicadores de productividad de autores, países, años, instituciones, idioma, tipo de estudio (teórico/empírico) y co-ocurrencia de términos. Se obtuvo un total de 1342 ponencias que resaltan a Cuba, México, Brasil y España como los países más participantes. Se destacan autores de algunos de estos países, procedentes mayormente del sector universitario. Los estudios presentados son mayormente empíricos, desde donde se destacan cinco líneas temáticas: (1) bibliometría, (2) educación y alfabetización en información, (3) gestión de información y del conocimiento, (4) actividad bibliotecaria y diseminación de información, y (5) tecnología de la información. Fueron obtenidos patrones de la productividad investigativa en información a través de dos de los eventos científicos más representativos dentro de la comunidad científica iberoamericana.
Médiation scientifique
Authors: Bergeron Andrée
Published: December 2016

Cet article s’intéresse à la « médiation scientifique » considérée comme catégorie. Il s’attache à en restituer l’émergence au cours des deux dernières décennies du xxe siècle en France dans le double contexte de la montée en puissance des médiations de tous ordres, d’une part, et des constantes tentatives de remplacement du mot « vulgarisation ». Il montre les liens forts qui existent entre la promotion de cette nouvelle appellation et la professionnalisation croissante des institutions culturelles (scientifiques ou non).
Voyage à la recherche du chaînon manquant de l’évolution
Authors: Husti Carmen
Published: December 2016

Cet article analyse la façon dont Jules Verne s’est inspiré des théories biologiques en circulation à la fin du xixe siècle – notamment chez Georges Pouchet, Armand de Quatrefages et Louis Figuier - concernant la limite qui sépare l’humain de l’animal ainsi que l’existence d’un chaînon manquant de l’évolution entre l’homme et le singe dans son roman Un village aérien publié en 1901.
Le corps dégénéré : des textes scientifiques à la littérature française du xixe siècle
Authors: Percheron Bénédicte
Published: December 2016

En 1766, Buffon tente de rendre compte des variations dans l’espèce humaine par un phénomène qu’il nomme dégénération. Repris par les naturalistes, étendu à l’ensemble du vivant, puis introduit dans la littérature, le concept séduit par sa puissance et par ses potentialités imaginaires. De Nodier aux romans d’anticipation de la fin du xixe siècle, le corps humain se dégrade pour rejoindre les espèces considérées comme inférieures ou au contraire se perfectionne pour se libérer des lois de la physique terrestre. Avec la réutilisation et l’élargissement de la notion par le médecin Morel dans son Traité des dégénérescences physiques, intellectuelles et morales et des causes qui produisent ces variétés maladives, paru en 1857, le terme devient une notion importante de la psychiatrie et se charge d’une connotation morale. De l’espèce à l’individu, du physique au psychique, le terme renvoie à de multiples réflexions dont nous souhaitons évaluer les enjeux.
Le retrait de la Fédération de Russie de sa signature du traité de Rome ou l’art de pervertir le droit des traités
Authors: Runavot Marie-Clotilde
Published: December 2016

Par décret présidentiel du 16 novembre 2016, la Russie a annoncé sa « volonté (…) de ne pas prendre part au Statut de Rome de la Cour pénale internationale ». Une telle prétention de retrait de signature du Statut de Rome a été annoncée au lendemain de la présentation du Rapport du Procureur de la CPI sur les activités menées en 2016 en matière d'examen préliminaire, lequel gêne visiblement Moscou. Pourtant, ni le droit des traités ni le Statut de Rome n’envisagent qu’un Etat puisse désigner un traité à l’égard duquel il n’a pas manifesté son consentement à être lié. La démarche russe constitue donc un nouvel exemple d’instrumentalisation du droit international.
Feasibility and Effectiveness of a Delirium Prevention Bundle in Critically Ill Patients
Authors: Smith Claudia DiSabatino , Grami Petra
Published: December 2016

Background

Strategies for preventing delirium include early identification and avoiding or modifying patient, environmental, and iatrogenic factors. Minimal research exists on a prescriptive delirium prevention bundle that details elements or strategies for each bundle component. Even less research has been focused on nurse-driven interventions or components.

Objective

To evaluate the effectiveness of a delirium prevention bundle in decreasing delirium incidence in 2 medical-surgical intensive care units in a large Texas medical center.

Methods

Researchers used the Confusion Assessment Method for the Intensive Care Unit to assess delirium incidence by using a controlled interventional cohort design with 447 delirium-negative critically ill patients. Bundle components consist of sedation cessation, pain management, sensory stimulation, early mobilization, and sleep promotion.

Results

The intervention, analyzed by using a logistic regression model, reduced the odds of delirium by 78% (odds ratio, 0.22; P = .001).

Conclusions

The delirium prevention bundle was effective in reducing the incidence of delirium in critically ill medical-surgical patients. Further validation studies are under way.
Role of CCL7 in Type I Hypersensitivity Reactions in Murine Experimental Allergic Conjunctivitis
Authors: Kuo Chuan-Hui , Collins Andrea M. , Boettner Douglas R. , Yang YanFen , Ono Santa J.
Published: December 2016

Molecules that are necessary for ocular hypersensitivity reactions include the receptors CCR1 and CCR3; CCL7 is a ligand for these receptors. Therefore, we explored the role of CCL7 in mast cell activity and motility in vitro and investigated the requirement for CCL7 in a murine model of IgE-mediated allergic conjunctivitis. For mast cells treated with IgE and Ag, the presence of CCL7 synergistically enhanced degranulation and calcium influx. CCL7 also induced chemotaxis in mast cells. CCL7-deficient bone marrow–derived mast cells showed decreased degranulation following IgE and Ag treatment compared with wild-type bone marrow–derived mast cells, but there was no difference in degranulation when cells were activated via an IgE-independent pathway. In vivo, CCL7 was upregulated in conjunctival tissue during an OVA-induced allergic response. Notably, the early-phase clinical symptoms in the conjunctiva after OVA challenge were significantly higher in OVA-sensitized wild-type mice than in control challenged wild-type mice; the increase was suppressed in CCL7-deficient mice. In the OVA-induced allergic response, the numbers of conjunctival mast cells were lower in CCL7-deficient mice than in wild-type mice. Our results demonstrate that CCL7 is required for maximal OVA-induced ocular anaphylaxis, mast cell recruitment in vivo, and maximal FcεRI-mediated mast cell activation in vitro. A better understanding of the role of CCL7 in mediating ocular hypersensitivity reactions will provide insights into mast cell function and novel treatments for allergic ocular diseases.
IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis
Authors: Huang Jinling , Yuan Qing , Zhu Hui , Yin Lan , Hong Shanjuan , Dong Zhongjun , Jin Wei , Dong Chen
Published: December 2016

Autoimmune hepatitis is a worldwide health problem and significant cause of mortality. However, the disease etiology is largely unknown, which accounts for ineffective treatment and uncontrolled disease progression. In this study, we demonstrated the functional importance of the IL-17C/IL-17RE axis in Con A–induced hepatitis. Elevated IL-17C expression was detected in liver samples of both human and mouse autoimmune hepatitis. IL-17C, produced by hepatocytes, and its specific receptor IL-17RE on liver-resident T cells were both found to be required in Con A–induced liver damage. Mechanistically, IL-17C augmented the expression of IL-2 by intrahepatic CD4+ T cells to promote NK cell activation and liver damage. To our knowledge, our findings thus for the first time defined the indispensable role of IL-17C/IL-17RE in autoimmune hepatitis; this axis may serve as a novel drug target for the treatment of this disease.
A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation
Authors: Peng Di , Wang Zining , Huang Anfei , Zhao Yong , Qin F. Xiao-Feng
Published: December 2016

The F-box proteins were originally identified as the key component of SKP1-Cullin1-F-box E3 ligase complexes that control the stability of their specific downstream substrates essential for cell growth and survival. However, the involvement of these proteins in type I IFN (IFN-I) signaling during innate immunity has not been investigated. In this study we report that the F-box protein FBXO17 negatively regulates IFN-I signaling triggered by double-strand DNA, RNA, or viral infection. We found that FBXO17 specifically interacts with IFN regulatory factor 3 (IRF3) and decreases its dimerization and nuclear translocation. The decrease of IRF3 dimerization and nuclear translocation is due to the recruitment of protein phosphatase 2 (PP2A) mediated by FBXO17, resulting in IRF3 dephosphorylation. Interestingly, PP2A recruitment does not require the F-box domain but instead the F-box associated region of the protein; thus, the recruitment is independent of the canonical function of the SKP1-Cullin1-F-box family of E3 ligase. Together, our studies identify a previously unreported role of FBXO17 in regulating IFN-I signaling and further demonstrate a novel mechanism for IRF3 deactivation by F-box protein-mediated recruitment of PP2A.
Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10–Mediated Responses
Authors: Marple Andrew , Wu Wenhui , Shah Suhagi , Zhao Yanlin , Du Peicheng , Gause William C. , Yap George S.
Published: December 2016

Concurrent helminth infection potently inhibits T cell immunity; however, whether helminthes prevent T cell priming or skew clonal recruitment and effector differentiation is not known. Using coinfection with two natural mouse pathogens, Heligmosomoides polygyrus and Toxoplasma gondii, to investigate the negative impact of helminthes on the CD8 T cell response, we demonstrate helminth-induced suppression of IL-12–dependent differentiation of killer-like receptor G1+ effector CD8 T cells and IFN-γ production. Nevertheless, reversal of helminth suppression of the innate IL-12 response of CD8α+ dendritic cells, which occurred in STAT6-deficient mice, was not sufficient to normalize CD8 T cell differentiation. Instead, a combined deficiency in IL-4 and IL-10 was required to reverse the negative effects of helminth coinfection on the CD8 T cell response. Monoclonal T. gondii–specific CD8 T cells adoptively transferred into coinfected mice recapitulated the spectrum of helminth-induced effects on the polyclonal CD8 T response, indicating the lack of requirement for clonal skewing.
Geology of the Labrador Shelf
Authors: Umpleby D C
Published: December 2016

The Cretaceous-Tertiary sequences penetrated by drilling operations on the Labrador Shelf have been divided into four formations for which formal names are proposed in this paper. The BerriasianValanginian Alexis Formation, up to 260 m thick, consists of
subaerially extruded basalt flows and associated sediments which overlie Precambrian basement containing outliers of Paleozoic rocks. The Alexis Formation is overlain by the Bjarni Formation, a series of predominantly continental coarse clastic rocks up to 1130 m thick of Hauterivian to Early
Neocomian age. The unconformably overlying Cartwright Formation, up to 1200 m thick, consists of shallow water marine turbiditic shales of Turonian to Early Eocene age. Locally, paralic to shallow water marine sand members occur in the Cartwright Formation. The conformably overlying Early Eocene
and younger Saglek Formation, over 1700 m thick, comprises a series of deeper water marine turbiditic mudstones overstepping the older formations. Within the Saglek Formation, shallower water and locally developed paralic sediments were deposited during the Late Eocene and Oligocene, a period of
reduced basin subsidence.
Structural sections across the Labrador margin show that two superimposed basins are present. The earlier, forming in the Berriasian, is bound by en echelon faults, trends approximately parallel to the present day Labrador coast and terminates on the northern flank of the Cartwright Arch. This
inshore basin is overstepped by Early Eocene and younger sediments which form a simple clastic wedge on the margin of the present day Labrador Sea, a basin apparently formed in the Late Cretaceous or Paleocene.
While the Labrador Sea is presumed by others to have resulted from seafloor spreading, this theory does not satisfactorily explain some important geological features. An alternative origin for the Labrador Sea proposed by the author is the collapse of a minor undation in lowermost Cretaceous times
followed by the collapse of a major undation in late Cretaceous times.
Three gas and condensate discoveries on the Labrador Shelf show similarities in structure and source though the reservoirs are different. In each discovery, closure is associated with upthrown faulted basement blocks within the inshore basin and the hydrocarbons appear to originate from the
Cartwright Formation. Insufficient data exist to assess the hydrocarbon potential of the Labrador Shelf but there are indications the area could prove to be an important hydrocarbon province.
Lithostratigraphy of the Lower Cretaceous Coal-bearing Sequence, Foothills of Alberta
Authors: Mclean J R
Published: December 2016

The Lower Cretaceous sequence in the Foothills of Alberta consists of a complex interfingering of mudstone, siltstone and sandstone with subordinate coal, conglomerate, limestone and bentonite. Lithofacies changes along the Foothills necessitate changes in
nomenclature. The Blairmore Croup in the southern Foothills of Alberta is divided into four formations in ascending order: Cadomin, Gladstone, Beaver Mines and Ma Butte. The Gladstone Formation is modified slightly from its original definition by excluding the basal conglomerate and sandstone unit
to which the name Cadomin Formation is applied. Ma Butte is a new name, introduced for the sequence of beds between the Beaver Mines and Crowsnest Formations. Use of the name Mill Creek, formerly used to encompass the Ma Butte and Crowsnest sequence, is discontinued. The name Crowsnest is retained
for the prominent volcanogenic unit overlying the Ma Butte Formation. The Crowsnest Formation is not recognized north of the Oldman River and the Ma Butte is absent north of Clearwater River. The Beaver Mines Formation is recognized as far north as Ram River although between Waiparous Creek and Ram
River, its lower beds are atypical of the formation and are an unmappable southern extension of the Malcolm Creek Formation. The nomenclature for the Lower Cretaceous succession in the central and northern Foothills of Alberta is substantially modified. The proposed succession, from the base upward,
is: Cadomin Formation, Gladstone Formation, Malcolm Creek Formation including Moosebar, Torrens und Grande Cache Members, and Mountain Park Formation. Ail of these formations are included in the Blairmore Croup, the use of which is extended to the central and northern Alberta Foothills to emphasize
the elements of similarity to the southern Alberta Foothills section. Use of the name Luscar is discontinued as it has not been used consistently and because the interval to which it was originally applied can be usefully divided into two distinct formations. The name Gladstone is applicable from
the type urea to near the Smoky River, north of which the name Gething is preferable. The Malcolm Creek and Mountain Park Formations are recognized to the Alberta-British Columbia border. North of this, the same interval is divided into the Moosebar, Gates, Hulcross and Boulder Creek Formations.
Coal seams of current economic interest south of Smoky River are confined to the Grande Cache Member of the Malcolm Creek Formation. They have been observed in the Alberta Foothills everywhere north of Waiparous Creek. One to six major seams occur in the member with thicknesses up to about 11 m.
Thick coal seams are also present in the Gething Formation along the Smoky River and to the north.
The canonical basis of the quantum adjoint representation
Authors: Lusztig George
Published: December 2016

We identify the canonical basis of the quantum adjoint representation of a quantized enveloping algebra with a basis that we defined before the theory of canonical bases was available.
Adapting and Evaluating a Rapid, Low-Cost Method to Enumerate Flies in the Household Setting
Authors: Wolfe Marlene K. , Dentz Holly N. , Achando Beryl , Mureithi MaryAnne , Wolfe Tim , Null Clair , Pickering Amy J.
Published: December 2016

Diarrhea is a leading cause of death among children under 5 years of age worldwide. Flies are important vectors of diarrheal pathogens in settings lacking networked sanitation services. There is no standardized method for measuring fly density in households; many methods are cumbersome and unvalidated. We adapted a rapid, low-cost fly enumeration technique previously developed for industrial settings, the Scudder fly grill, for field use in household settings. We evaluated its performance in comparison to a sticky tape fly trapping method at latrine and food preparation areas among households in rural Kenya. The grill method was more sensitive; it detected the presence of any flies at 80% (433/543) of sampling locations versus 64% (348/543) of locations by the sticky tape. We found poor concordance between the two methods, suggesting that standardizing protocols is important for comparison of fly densities between studies. Fly species identification was feasible with both methods; however, the sticky tape trap allowed for more nuanced identification. Both methods detected a greater presence of bottle flies near latrines compared with food preparation areas (P < 0.01). The grill method detected more flies at the food preparation area compared with near the latrine (P = 0.014) while the sticky tape method detected no difference. We recommend the Scudder grill as a sensitive fly enumeration tool that is rapid and low cost to implement.
Transverse Myelitis as an Unusual Complication of Dengue Fever
Authors: Mota Mânlio Tasso de Oliveira , Estofolete Cássia Fernanda , Zini Nathalia , Terzian Ana Carolina Bernardes , Gongora Delzi Vinha Nunes , Maia Irineu Luiz , Nogueira Maurício Lacerda
Published: December 2016

Dengue fever is the most common arbovirus disease, and presents with a large spectrum of clinical manifestations ranging from asymptomatic disease through to the development of dengue hemorrhagic fever. These extreme cases can lead to dengue shock syndrome, and sometimes death. Spinal cord involvement in dengue virus (DENV) infections is rare. Here, we report a case in which the patient developed acute transverse myelitis (TM) without paraparesis following a DENV infection. This case highlights the importance of physicians' awareness of the possible link between DENV and TM in endemic areas.
Women's oral and dental health aspects in humanitarian missions and disasters: Jordanian experience
Authors: Smadi, BDS, MDentSci, FDS RCSEd Leena , Al Sumadi, MD, FRCOG Aiman
Published: December 2016

Objective: The study aimed to review oral and dental health aspects in female patients presented to Jordanian Royal Medical Services (RMS) international humanitarian missions over a 3-year period.Design and Method: Analysis of humanitarian missions of RMS data and records over a 3-year period (2011-2013) in regard to women's oral and dental health issues was done. The data were analyzed in regard to the number of women seen, the presenting conditions, and the prevalence of oral and dental diseases and procedures in these cases.Results: During the 3-year period, 72 missions were deployed in four locations (Gaza, Ram Allah—West Bank, Jeneen—West Bank, and Iraq). The total number of females seen in this period was 86,436 women, accounting for 56 percent of adult patients seen by RMS humanitarian missions. Dental Clinics were deployed to only two missions (Iraq and Gaza), during which they received 13,629 visits; of these, 41 percent were females (5,588 patients), 29 percent were males, and 30 percent were in the pediatric age group. Trauma accounts for only 7 percent of the cases, while nonacute dental problems (caries and gingivitis) were responsible for the majority of cases (31.6 and 28.7 percent, respectively).Conclusion: RMS dental services during humanitarian mission deployment are a vital part of comprehensive healthcare. Women usually seek more dental care than men, with the majority of treatments for nonacute conditions. RMS experiences demonstrate the tremendous need for a well-defined preparedness plan for deployment of humanitarian missions that considers the contributions of all types of health professionals, the appropriate mobile technology to respond to emergent health risks, and a competent workforce ready and able to respond. Such preparation will require our dental education programs to develop disaster preparedness competencies to achieve the desired level of understanding.
Injury-related fatalities in selected governorates of Iraq from 2010 to 2013: Prospective surveillance
Authors: Bilukha, MD, PhD Oleg O. , Sultan, MBChB, DM Abdul-Salam Saleh , Hassan, MBChB, FICMS Ahmed , Hussain, MD Syed Jaffar , Leidman, MSPH Eva
Published: December 2016

Objective: After several years of relative stability in Iraq, the emergence of the Islamic State militant group has spurred a resurgence of violence. This study explores the impact of the conflict on the overall injury profile to estimate the proportion of injury fatalities related to conflict and better understand how violence has affected nonconflict-related injuries.Design: Routine prospective injury surveillance operated by the Iraqi Ministry of Health.Setting: Surveillance data were collected from coroner offices in eight pilot governorates: Al-Anbar, Baghdad, Basrah, Erbil, Kerbala, Maysan, Ninevah, and Al-Sulaimaniya.Participants: We analyzed all fatalities from external injury causes recorded between January 1, 2010 and December 31, 2013. Analysis included 32,664 fatal injuries.Results: Of all injury fatalities reported, 27.1 percent were conflict-related fatalities, approximately the same proportion as road traffic-related fatalities (24.4 percent) and other unintentional injuries (27.5 percent). The proportion of fatalities from conflict was approximately three times higher among males than females (33.0 percent and 10.3 percent, respectively) and four times higher among adults than children (29.8 percent and 7.3 percent, respectively). The total number of injury fatalities remained stable between 2010 and 2012; an increase in injury fatalities in 2013 was driven primarily by increases in fatalities from both interpersonal violence and conflict.Conclusions: From 2010 to 2013, nearly one in four injury fatalities in Iraq was attributable to conflict, a notably higher proportion than other conflict-affected countries in the region. The overall profile of nonconflict injuries in Iraq is also distinct from other countries of similar socioeconomic level that have not experienced violence.
Social support for terror-related victims: The Israeli system
Authors: Ellenberg, MD, PhD Eytan , Sasporte, LLB Jacob , Bar-on, MD, MHA Zvia , Sfez, LLD Rolland , Cohen Osnat , Taragin, MD, MPH Mark , Ostfeld, MD, MHA Ishay
Published: December 2016

Since its foundation, the State of Israel has been affected by terror violence toward its civilian population. For more than 45 years, the Israeli legislation has built a legal insurance allowing citizens casualties of such violence to benefit from specific coverage and support. The objective of this article is to describe the history, legal framework, and organization of social support for terror victims in Israel.
The acid-catalyzed hydrolysis of an α-pinene-derived organic nitrate: kinetics, products, reaction mechanisms, and atmospheric impact
Authors: Rindelaub Joel D. , Borca Carlos H. , Hostetler Matthew A. , Slade Jonathan H. , Lipton Mark A. , Slipchenko Lyudmila V. , Shepson Paul B.
Published: December 2016

Abstract. The production of atmospheric organic nitrates (RONO2) has a large impact on air quality and climate due to their contribution to secondary organic aerosol and influence on tropospheric ozone concentrations. Since organic nitrates control the fate of gas phase NOx (NO + NO2), a byproduct of anthropogenic combustion processes, their atmospheric production and reactivity is of great interest. While the atmospheric reactivity of many relevant organic nitrates is still uncertain, one significant reactive pathway, condensed phase hydrolysis, has recently been identified as a potential sink for organic nitrate species. The partitioning of gas phase organic nitrates to aerosol particles and subsequent hydrolysis likely removes the oxidized nitrogen from further atmospheric processing, due to large organic nitrate uptake to aerosols and proposed hydrolysis lifetimes, which may impact long-range transport of NOx, a tropospheric ozone precursor. Despite the atmospheric importance, the hydrolysis rates and reaction mechanisms for atmospherically derived organic nitrates are almost completely unknown, including those derived from α-pinene, a biogenic volatile organic compound (BVOC) that is one of the most significant precursors to biogenic secondary organic aerosol (BSOA). To better understand the chemistry that governs the fate of particle phase organic nitrates, the hydrolysis mechanism and rate constants were elucidated for several organic nitrates, including an α-pinene-derived organic nitrate (APN). A positive trend in hydrolysis rate constants was observed with increasing solution acidity for all organic nitrates studied, with the tertiary APN lifetime ranging from 8.3 min at acidic pH (0.25) to 8.8 h at neutral pH (6.9). Since ambient fine aerosol pH values are observed to be acidic, the reported lifetimes, which are much shorter than that of atmospheric fine aerosol, provide important insight into the fate of particle phase organic nitrates. Along with rate constant data, product identification confirms that a unimolecular specific acid-catalyzed mechanism is responsible for organic nitrate hydrolysis under acidic conditions. The free energies and enthalpies of the isobutyl nitrate hydrolysis intermediates and products were calculated using a hybrid density functional (ωB97X-V) to support the proposed mechanisms. These findings provide valuable information regarding the organic nitrate hydrolysis mechanism and its contribution to the fate of atmospheric NOx, aerosol phase processing, and BSOA composition.
Influence of urban pollution on the production of organic particulate matter from isoprene epoxydiols in central Amazonia
Authors: de Sá Suzane S. , Palm Brett B. , Campuzano-Jost Pedro , Day Douglas A. , Newburn Matthew K. , Hu Weiwei , Isaacman-VanWertz Gabriel , Yee Lindsay D. , Thalman Ryan , Brito Joel , Carbone Samara , Artaxo Paulo , Goldstein Allen H. , Manzi Antonio O. , Souza Rodrigo A.F. , Mei Fan , Shilling John E. , Springston Stephen R. , Wang Jian , Surratt Jason D. , Alexander M. Lizabeth , Jimenez Jose L. , Martin Scot T.
Published: December 2016

Abstract. The atmospheric chemistry of isoprene contributes to the production of a substantial mass fraction of the particulate matter (PM) over tropical forests. Isoprene epoxydiols (IEPOX) produced in the gas phase by the oxidation of isoprene under HO2-dominant conditions are subsequently taken up by particles, thereby leading to production of secondary organic PM. The present study investigates possible perturbations to this pathway by urban pollution. The measurement site in central Amazonia was located 4 to 6 hours downwind of Manaus, Brazil. Measurements took place from February through March 2014 of the wet season, as part of the GoAmazon2014/5 experiment. Mass spectra of organic PM collected with an Aerodyne Aerosol Mass Spectrometer were analyzed by positive-matrix factorization. One resolved statistical factor (“IEPOX-SOA factor”) was associated with PM production by the IEPOX pathway. Loadings of this factor correlated with independently measured mass concentrations of tracers of IEPOX-derived PM, namely C5-alkene triols and 2-methyltetrols (R = 0.96 and 0.78, respectively). Factor loading, as well as the ratio of the factor loading to organic PM mass concentration, decreased under polluted compared to background conditions. For the study period, sulfate concentration explained 37 % of the variability in the factor loading. After segregation of the data set by NOy concentration, the sulfate concentration explained up to 75 % of the variability in factor loading within the NOy subsets. The sulfate-detrended IEPOX-SOA factor loading decreased by two- to three-fold for an increase in NOy concentration from 0.5 to 2 ppb. The suppressing effects of elevated NO dominated over the enhancing effects of higher sulfate with respect to the production of IEPOX-derived PM. Relative to background conditions, the Manaus pollution contributed more significantly to NOy than to sulfate. In this light, increased emissions of nitrogen oxides, as anticipated for some scenarios of Amazonian economic development, could significantly alter pathways of PM production that presently prevail over the tropical forest, implying changes to air quality and regional climate.