bluuebunny/crossref_metadata_2025 huggingface dataset:
THEORETICAL ANALYSIS OF THE PROBLEM OF PROFESSIONAL ADAPTATION OF TEACHERS OF SECONDARY EDUCATION INSTITUTIONS
Authors: KUZMENKO N. , PROTSENKO I.
Published: April 2021

The article «Theoretical analysis of the problem of professional adaptation of secondary school teachers» is devoted to the theoretical substantiation of the adaptation of young teachers to the professional activity of secondary schools. The presented research uses a set of interrelated methods: theoretical (analysis of pedagogical, psychological literature and teaching materials to determine the real state of training of future secondary education teachers), empirical (questionnaires, surveys and interviews). allows to calculate and assess the level of socio-psychological adaptation of future teachers ZZSO.In the process, a set of research methods was used: theoretical: analysis of philosophical, managerial, psychological and pedagogical domestic and foreign pedagogical literature on the research topic to clarify the state of the problem; systematization, comparison, generalization and modeling of scientific and theoretical material for studying the essence and content of professional adaptation of teachers.

The methodological and theoretical basis of the study are the leading provisions of pedagogy, psychology, philosophical concepts devoted to the study of socio-professional adaptation of young teachers); conceptual ideas for self-realization of the individual; provisions on activity - personal orientation of the pedagogical process; creating a comfortable environment; theoretical and practical developments on aspects of adaptation of young professionals. The method of analysis allowed to generalize the essence of the basic concepts: "adaptation", "professional adaptation", "maladaptation". Based on the analysis and synthesis of scientific and pedagogical literature, professional adaptation is mostly understood by managers as a one-sided process of mastering the existing requirements for professional activity (with adaptation to specific requirements of a particular school) and is not considered as a process of active introduction of new ideas. activities. As a result of such an approach, sufficient conditions are not created for a high level of activity, creativity of teachers, their self-expression in professional activities. Analyzing the content of primary adaptation as a whole, school principals do not clearly understand and comprehend the content of secondary adaptation of teachers (related to changes in the type of educational institution, changes in student assessment, introduction of new information and computer technologies, rather dynamic changes in mental development of children, crisis stages in the professional development and professional career of teachers themselves, as well as transformational processes in society).
FORMATION OF SOCIAL ACTIVITY OF STUDENT YOUTH BY MEANS OF STUDENT SELF-GOVERNMENT IN THE COURSE OF PROJECT ACTIVITY
Authors: PECHONKINA L. , MANZYUK M.
Published: April 2021

The article considers the essence and ways of solving an important task of a modern secondary school - the formation of social activity of student youth. Possibilities of student self-government in the context of solving this problem are analyzed. One of the ways of social activation of schoolchildren is considered - their involvement in work on various projects, during the implementation of which students learn to identify socially significant problems and make fruitful efforts to solve them.

The purpose of the article is to substantiate the feasibility of using student government projects to form the social activity of student youth.

The results of the research are given, which give grounds to consider student self-government as an actual and perspective means of activating schoolchildren as members of society, young citizens of Ukraine. One of the activities of student government, which is comprehensive and contributes to its effectiveness and influence in the school and out-of-school environment, is a project activity, which today has a wider scope and deserves further study, in particular in the context of solving educational problems of secondary school .
LABOR ACTIVITY AS A MEANS OF SENSITIVITY EDUCATION AMONG PRESCHOOL CHILDREN
Authors: STANICHENKO O.
Published: April 2021

The article analyses the question of theoretical and methodological basis of labor education of preschool year children. The focus of this study is on the need to look at moral education through a retrospective of labor education. Much attention is given to the work teachers of the past (D. Locke, K. Ushinsky, A. Makarenko, V. Sukhomlinsky, etc.) who used work as a means of comprehensive development of the child. In Soviet times, thorough systematic research was conducted in this area (Z. Borysova, T. Vvedenska, V. Nechayeva, V. Pavlenchyk). Considering the issue of preschooler labor education, researchers have proved the educational significance of children's work in educational institutions, linking it with the formation of individual moral qualities. Modern Ukrainian scientists (G. Byelyenka, O. Dolynna, M. Mashovets, O. Nyzkovska) recommend to promote the active participation of children in hard work from an early age that will determine the formation of their work skills and positive attitude to work. They argue that labor education in preschool childhood contributes to the effective development of moral qualities of individual, the improvement of the educational process. The necessary moral qualities of the child's personality are formed in the relationship of labor and moral education. They are responsibility, diligence, mutual assistance, etc. The analysis of scientists’ research shows that the up-to-date development of this problem is marked by the lack of attention to it.

The author gives the reasons for the necessity of cultivating the sensitivity by means of labor activity within the preschool children. Extensive coverage is given to involving preschoolers in hard work that is associated with the care of animals and plants, having the aim to improve the morality of personality. The author points out that the effectiveness of the use of labor in nature as a form of work in preschool education, in order to improve children sensitivity through daily taking care of animals and plants. The author argues that sensualy-joyful knowledge of the natural environment by preschool children, their humane perception of living beings is a reliable background for the formation of sensitivity in childhood. At the same time, the study confirms that children are not isolated from suffering, grief and worries. Having the opportunity for such an experience, children understand the necessity of care process.
21 ST CENTURY SKILLS IN SCHOOL EDUCATION IN THE UNITED KINGDOM
Authors: TIMENKO M.
Published: April 2021

The author of the article considers and characterizes the main current trends in the development of school education in the UK. The author describes the necessary skills of the XXI century for students of secondary schools in Great Britain and the conditions of their formation. These are skills such as: joint problem solving, responsibility, critical thinking, creativity, emotional intelligence, cooperation, decision making, IT skills, self-regulation, communication, flexibility and adaptability, respect, information and economic literacy, etc. The author also describes the so-called soft skills (flexible) and hard skills (hard). The article notes the role of the 21st century teacher, which today cannot be limited to knowledge transfer, but to focus, discuss and, of course, evaluate students' progress so that they know when more support is needed, as today's innovative schools design classes for knowledge. , not its transportation.

It is argued that modern and relevant and key skills of the 21st century include: problem solving, critical thinking, creativity, collaboration, decision making, IT skills, self-regulation, communication, respect, information and economic literacy, which in turn require appropriate teaching methods of the 21st century. The role of teachers can no longer be limited to knowledge transfer, but should be well-guided, discussed and, of course, evaluated by students' progress so that they know when more support is needed. Today, innovative schools design classrooms for the pursuit of knowledge, not its transportation.
FEATURES OF THE USE OF AUDIOVISUAL TEACHING AIDS IN TEACHING THE COURSE "BIOGEOGRAPHY"
Authors: KHANNANOVA O. , SHKURA T.
Published: April 2021

The article is devoted to the consideration of pedagogical and organizational conditions for the use of audiovisual teaching aids in teaching the course "Biogeography" at Poltava Pedagogical University named after V.G. Korolenko. The ways of introduction of modern video teaching aids in the educational process are analyzed.

It is proved that the use of audiovisual teaching aids in the study of disciplines "Biogeography", "Biogeography with the basics of landscape science" is aimed at deepening the acquisition of knowledge, skills and abilities about the peculiarities of the distribution of living organisms on Earth. Learning material illustrated using audiovisual teaching aids is an effective form of learning. The optimal use of audiovisual media allows you to develop classes more informative, interesting and meaningful, but requires much more time to prepare from the teacher in order to clearly organize the participants in the educational process.
DESIGNING THE BASIS OF THE SHOULDER PRODUCT USING THE TECHNOLOGY OF ECOLOGIKAL PROCESSING OF TEXTILE MATERIALS
Authors: CHYSTIAKOVA L. , KUTSENKO T.
Published: April 2021

In condition of nowadays, it raises the question of life and professional realization of the individual, the ability to use and acquire knowledge throughout life, to build own professional path, while having a high level of general and professional culture.

Future specialists of professional education (Technology of light industry goods) acquire object and professional competencies in the process of educational and research activities, including the mastering of the method of clothing design that is decisive. The development of general competencies is no less important, especially awareness of the values of sustainable development of society, including environmental culture, which is formed in the process of education. The improvement of this training helps students to do creative projects on the technology of ecological processing of textile materials, which corresponds to the introduction of the principles of sustainable fashion into the educational process.

The article also describes the technology of "upcycling", which expects the reuse of textiles and clothing. It is the process of creating a new thing from another one that is not used any more. Its potential is the formation students’ environmental culture and the relevant skills of resource conservation. Since the amount of material is limited, there is a need to build an accurate design of the product base, which can be used further modeling a new product without extra elaboration.

The article presents the substantiation of one of the methods of constructing the basis of the shoulder product – dip transfer welding, which is one of the effective one when students do creative projects on the manufacture of garments using the technology of ecological processing of textile materials. Involving students in such projects contributes to the formation of environmental culture, forms an idea of sustainable fashion, and it is an effective way to slow down fashion.

The creating of an algorithm for building the basis of the shoulder product on a non-standard figure will contribute to the formation of object competencies of students during doing creative projects using the technology of ecological processing of textile materials.
DEVELOPMENT OF THE FUTURE MANAGER'S ABILITY TO CREATE AN EFFECTIVE BUSINESS IMAGE
Authors: SHTEPA N. , ZDIR M.
Published: April 2021

The essence and components of the manager's business image, criteria of its efficiency are analyzed.

Under the effective business image, the authors understand the image of the future manager in the perception of his colleagues, partners, customers, the public, which contributes not only to a positive attitude towards this person, but is a business and emotional core of successful joint activities. Its creation requires from the manager the formed image competence which is reached only by long enough and various work on itself, and, therefore, should be put from the first days of study at university, in particular, studying of specially oriented training courses.

As an example of such training, the article substantiates the importance of studying the course "Fundamentals of Imageology" for future managers. Features of application of interactive techniques for development of ability of the future manager to design and creation of effective business image are considered.
Protective Effects of Zeolite (Clinoptilolite) on Copper Toxicity in Tilapia (Oreochromis niloticus)
Authors: TÜRKMEN Mustafa , DİNLER Zühtü Mete
Published: April 2021

In this study, the protective effect of zeolite added to water on tilapias exposed to sub-lethal concentration of copper was investigated. Treatments were copper, copper + zeolite, zeolite and control. During the experiment, fish growth by weight and length, copper accumulation in liver, and muscle protein ratios were measured. BUN, LDH, glucose, cholesterol, and triglyceride parameters of blood were also measured by taken monthly blood samples. The greatest increase in weight was observed in zeolite treatment by 68.8%. Liver copper accumulations were 12.6; 10.8; 1.27 and 1.33 ppm for the copper, copper + zelite, zeolite and control treatment, respectively. Although, BUN, LDH, cholesterol of copper + zeolite treatment were lower, triglyceride and glucose levels were higher comparing to control group (p
A Preliminary Study on Zooplankton Fauna of Kızılca Pond (Konya-Seydişehir/Turkey)
Authors: APAYDIN YAĞCI Meral , ERBATUR İsmail , DEMİR Abdullah , YAĞCI Abdulkadir
Published: April 2021

Kızılca Pond has the most intensive population of Giant Spring Minnow fish (Pseudophoxinus anatolicus). In order to draw attention to the distribution area of the Anatolian endemic species, this pond was chosen as the study area and this preliminary study was carried out on one-time zooplankton species diversity in July 2018. Zooplankton samples were taken from the pelagic part of the lake at 8 m depth (sampling just once from this depth). Also, samples were collected with Hydro-Bios model plankton net with 55 μm mesh size. Physicochemical parameters of the lake (pH, conductivity,water temperature, dissolved oxygen concentration, saturation of dissolved oxygen) were measured. The zooplankton fauna of the pond consist of Rotifera (87%) and Cladocera groups (13%). The dominant species were recorded as Asplanchna priodonta, Keratella cochlearis and Testudinella patina.
Sistem pemantauan dan pengisian cairan pada mesin hemodialisa berbasis IoT dengan protokol MQTT
Authors: Aprinaldi Yanda , Saputra Dede Irawan
Published: April 2021

Masalah yang sering terjadi saat melakukan cuci darah adalah habisnya cairan acid dan bicarbonate saat proses cuci darah sedang berlangsung yang mengakibatkan efek samping pada pasien. Internet of Things (IoT) merupakan metode komunikasi sederhana yang dapat menghubungkan semua objek fisik di kehidupan sehari-hari melalui internet. Pada penelitian ini dibuat prototype berbasis IoT yang mampu memonitor dan mengisi ulang cairan acid dan bicarbonate dan dapat mengisi ulang cairan sebelum kosong. Sistem dibuat menggunakan sensor ultrasonic dan aliran untuk pendeteksian cairan. Pengiriman data pada sistem ini dilakukan menggunakan protokol Message Queuing Telemetry Transport (MQTT). Hasil pengujian menunjukkan sistem mampu berjalan dengan baik dengan tingkat error data sensor ultrasonik yang sudah terkalibrasi sebesar 0,105 cm dan error sensor flowmeter sebesar 0,11 L/m. Hasil pembacaan pada serial monitor memiliki hasil yang sama dengan pembacaan yang ditampilkan interface. Data yang dikirimkan mencapai kesesuaian 100% dikarenakan pada sistem monitor dan pengisian ini dilakukan menggunakan protokol MQTT yang terdapat publish, subscribe, dan broker.
SAĞLIK HİZMETLERİNDE DEĞER TEMELLİ YÖNETİM: DEĞER TEMELLİ ÖDEME MODELLERİ
Authors: Kopuz Koray , Akman Eren
Published: April 2021

Günümüzde sağlık sektöründe hizmet başına ödeme modeli yaygın olarak kullanılmakta ve bu modelde ağırlıklı olarak hizmetin hacmi ödüllendirilmektedir. Hacmin ödüllendirilmesi, daha fazla hizmet sunumuna ve maliyet artışına neden olmaktadır. Sağlık alanında değer temelli yönetim yaklaşımı Porter ve Teisberg tarafından 2006 yılında ortaya konulmuştur. Bu yaklaşımın amacı yüksek değere ulaşmaktır. Değer kavramı ise paraya çevrilebilen girdilere göre sağlık sonuçları şeklinde tanımlanmaktadır. Değer artarsa sağlık sisteminin sürdürülebilirliği artar ve bütün paydaşlar bundan fayda sağlayabilir. Sağlık sektöründe pek çok alanda değer temelli yaklaşımlar kullanılmakla birlikte bunlardan bir tanesi de değer temelli ödemedir. Değer temelli ödeme modelleri, hizmet başına ödeme modelinin aksine, hastaneler ve hekimler de dâhil olmak üzere bütün hizmet sunucularını, olumlu sonuçlar üreten yüksek kaliteli ve uygun maliyetli bakım sağlamaları için ödüllendirir. Değer temelli ödeme modellerinin; ödül ve performans kriterlerinin belirlenmesi, ödemenin bir kısmının hizmet sunumu sonrası alınması, maliyetlerin ölçülmesi, paydaşlar arası koordinasyon sağlanması, taraflar arasında risklerin dağılımı gibi bir takım uygulama zorlukları bulunmaktadır. Ancak hizmet kalitesinin arttırılması, sağlık hizmeti maliyetlerinin düşürülmesi, ödeyici kurumlar açısından ödeme verimliliğinin arttırılması, kanıta dayalı bakım sağlanması, komplikasyonların azaltılması, bakım koordinasyonunun güçlendirilmesi ve geri ödemelerde artışın sağlanması gibi pek çok fayda sağlar. Bu çalışmanın amacı değer temelli ödeme modellerinin kullanımı ile ilgili genel bir çerçeve oluşturmak ve değer temelli ödemeye geçiş sürecinde dikkat edilmesi gereken noktaları ortaya koymaktır.
Marketing digital y posicionamiento web en comunicación científica
Authors: Mandiá Rubal Sara , López Ornelas Maricela
Published: April 2021

La Red opera hoy como una gran biblioteca global self-service, abierta 24x7, en la que hay que saber describirse para optar a ser recuperado. Se produce una simbiosis entre producción científica, perfil académico ―identidad digital, personal branding― y ciencia visible. A partir de una muestra realizada a 2257 investigadores españoles del área de Comunicación, referente a su producción científica, visibilidad e impactos alcanzados, según su ausencia o presencia activa en perfiles de Internet; y habiendo concluido como relevante el uso de redes académicas para capturar la atención del área; se plantea ahora la siguiente fase de investigación, estudiar la influencia positiva de diseñar y aplicar estrategias propias del marketing digital y el posicionamiento web al perfil de un investigador junior, desde su etapa predoctoral a la actualidad ―postdoctorado, con algunas publicaciones arbitradas―. Desde la triangulación, se toman para el análisis cuantitativo, los flujos de visitas registrados en ORCID, Google Scholar, Publons, ReaserchGate, Academia.edu, Directorio Exit y Mendeley; para el análisis cualitativo, una entrevista personal al sujeto de estudio. No sólo se verifica la hipótesis de investigación ‘una presencia activa y bien planificada en Internet mejora la visibilidad del investigador, también en el mundo analógico’ sino que se extraen interesantes totales del análisis web realizado a través de la herramienta SEO, SemRush.
Providing a framework for knowledge sharing in knowledge-based organizations according to social capital indicators
Authors:   Malek Ashtar University of Technology, Tehran, Iran, Ghorbani Saeed , Naghdi Khanachah Shayan ,   Malek Ashtar University of Technology, Tehran, Iran
Published: April 2021

Purpose: This study aimed to provide a framework for examining knowledge sharing from the perspective of social capital in knowledge-based organizations. For this purpose, the social capital and knowledge sharing literature has been reviewed and appropriate dimensions and components have been selected for use in the proposed framework. Research methodology: The number of experts participating in this study was 12. Kendall’s W Ranks is a statistical index for assessing the degree of agreement in a group. This statistical index, which is related to non-parametric statistics, is used to assess the degree to which a number of evaluators agree on the ranking of several factors. Result: This research's proposed framework shows that the main bottleneck in the knowledge sharing process is the sender. Numerous factors affect the motivation, quantity and quality of knowledge shared by him. The proposed conceptual model shows the factors in the field of social capital well. This means that the organization's managers should pay special attention to people with knowledge to activate the process of knowledge sharing in the organization as a driving force. Limitations: This research only described knowledge-based organizations. Contribution: The proposed conceptual framework makes a good distinction between formal and informal knowledge-sharing channels in a knowledge-based organization. Formal channels are controlled and manageable channels. Although the main burden of knowledge sharing in organizations lies with informal channels, the more managers can shift the organization's knowledge to formal channels, the more they can manage the process. This is a part of the job that social capital, in particular, helps to achieve. The proposed framework discusses the acceptance of the use of formal frameworks. Keywords: Social capital, Knowledge management, Knowledge sharing, Expertise method
Hulladékok mintavételezése és mintavételezési módszerek bemutatása
Authors: Romenda Roland , Nagy Sándor , Faitli József
Published: April 2021

A hulladékkezelők egyik adatszolgáltatási kötelezettsége – a hivatali szervek felé – a telephelyre bekerülő hulladékok mennyiségének és összetételének közlése. Utóbbi feladatot mintavételezéssel és az összetételre irányuló analízissel lehet kielégíteni, amelyet többnyire erre a célra specializálódott cégek végeznek. A mintavételezésből és analízisből származó adatok felhasználhatóak a különféle feldolgozó rendszerek technológiai tervezésére, a meglévő rendszerek hatékonyságának ellenőrzésére, módosítására vagy egyéb, a hulladékok energetikai vagy anyagában történő hasznosításával, feldolgozásával kapcsolatos kutatásokra. Mivel mindezen területeket nem lehet egyfajta hulladékelemzési szabvánnyal megoldani, ezért különböző módszerek alkalmazására van szükség. A tanulmány a szerzők és korábbi szerzőtársainak eredményeit és megállapításait mutatja be néhány projekten keresztül.
FDM/FLM/FFF 3D nyomtatók típusainak összehasonlítása
Authors: Csehi Bálint , Bihari Zoltán
Published: April 2021

Ez a cikk az FDM/FLM/FFF technológiát használó 3D nyomtatók vázszerkezetét, extruder- és nyomtatófej-kialakításait vizsgálja. Összehasonlítjuk a különböző lehetőségeket, azt vizsgálva, hogy milyen hibalehetőségekkel kell számolnunk egy tetszőleges 3D nyomtatónál, annak vázától az egyéb mechanikai elemeivel bezárólag.
Drying behaviour observations for wood chips of grade EN14961
Authors: Kumar Baibhaw , Szepesi L. Gábor , Szamosi Zoltán
Published: April 2021

Solid biofuels such as woodchips have always been a significant source of fuel in the field of renewable energy. However, the drying of wood chips has been a challenge in preparing biofuels and other applications. The moisture content of below 25% in the wood chips of grade EN 14961 is considered the premium wood chip material. Solar drying emerged as a leading solution for the drying of wood chips. The paper investigates the comparison of moisture removal rate using a natural convective solar dryer compared to open sun drying developed at Miskolc, Hungary (48°06'15.0"N 20°47'30.0"E).
Topológiai optimalizálási feladatok alapvető sajátosságai Abaqus végeselemes programrendszerben
Authors: Gönczi Dávid
Published: April 2021

Jelen cikk a modern mérnöki gyakorlatban egyre többet alkalmazott optimalizálási technikák, azon belül is részletesebben a topológiai optimalizálási problémák kereskedelmi végeselemes szoftverekkel való megoldásával foglalkozik. Bemutatásra kerülnek az Abaqus általános célú VEM szoftveren belül az optimalizálási eljárás főbb jellemzői. Áttekintjük a modern mérnöki anyagok, mint például a kompozitok, avagy a funkcionálisan gradiens anyagok vizsgálatának lehetőségeit is egyszerű mintapéldákon keresztül.
Topológiai módszerek alkalmazása
Authors: Szabó Kristóf
Published: April 2021

Az alábbi cikk röviden összefoglalja a napjainkban alkalmazható tervezést segítő módszereket, mint például az integrált CAD rendszerekben elterjedő topológiai optimalizációt és a generatív tervezést. Az említett módszerek nyújtotta eredményeket egy esettanulmány segítségével mutatjuk be és hasonlítjuk össze.
Staircase Selective Harmonic Elimination in Multilevel Inverters to Achieve Wide Output Voltage Range
Authors: Pourdadashnia Amirhossein , Farhadi-Kangarlu Mohammad , Sadoughi milad
Published: April 2021

12th Annual Power Electronics, Drive Systems and Technologies (PEDSTC 2021)
Biomonitoring Pajanan Pestisida Organofosfat pada Pekerja Pertanian
Authors: Liem Jen Fuk
Published: April 2021

Untuk mengendalikan organisme pengganggu, kegiatan pertanian pada umumnya menggunakan pestisida secara rutin diantaranya insektisida organofosfat (OP). Oleh karenanya, para pekerja di sektor pertanian terutama mereka yang bertugas mengaplikasikan pestisida akan terpajan dengan OP dalam jumlah tertentu dan berisiko mengalami dampak kesehatan. Penilaian pajanan bahan kimia atau efeknya dengan mengukur kandungan bahan kimia tersebut, dalam hal ini pajanan OP, dapat dilakukan melalui biomonitoring. Pemilihan biomarker, matrik biologis, dan waktu pengambilan spesimen merupakan faktor penting yang harus direncanakan dengan cermat mengingat bahwa keberadaan biomarker pajanan OP sangat dipengaruhi oleh proses metabolisme toksikan. Mekanisme toksisitas organofosfat (OP) telah diketahui secara luas yaitu berlangsung melalui penghambatan enzim asetilkolinesterase (AChE). Sehubungan dengan hal tersebut, pemeriksaan pajanan pestisida OP umumnya terbatas pada pemeriksaan asetilkolinesterase (AChE) maupun butirilkolinesterase (BChE) yang memberikan informasi mengenai keberadaan pajanan OP namun tidak secara spesifik menunjukkan agen penyebabnya. Artikel ini membahas informasi mengenai parameter monitoring biologis yang dapat dilakukan untuk menilai pajanan pestisida OP pada pekerja di sektor pertanian.
The Relationship of Interferon Gamma +874T/A and Interleukin-10 -1082G/A Gene Polymorphism to The Recovery of Multidrug Resistant Tuberculosis Patients
Authors: Haryatie Ita , Harsini Harsini , Reviono Reviono
Published: April 2021

Background: Multidrug resistant (MDR) TB caused by the M.Tb strain is resistant toward at least rifampicin and isoniazid. Interferon Gamma is responsible for activating macrophages and phagocytosis for M.Tb destruction. Interleukin 10 causes a significant decrease in reactive nitrogen intermediates, increased arginase 1, and overall decreased macrophage function. Gene mutation causes IFN production by CD4 - T cells less effective and disrupts the immune response against M.Tb. There has been no research on the relationship between IFN-γ and IL-10 gene polymorphisms with TB recovery in Indonesia, especially in patients with MDR-TB. The aim of this study is to determine gene polymorphism relationship of IFN-γ +874T/A and IL-10 -1082G/A with MDR-TB recovery.

Methods: This study was a non-experimental clinical trial with a retrospective cohort design. The study was conducted on 105 MDR-TB patients treated in dr. Moewardi Hospital between January 2011-June 2014 consists of 84 recovered patients and 21 patients died/failed.

Results: Gene polymorphism of IFN-γ +874T/A was obtained OR=0.703 (0.265-1.863) and P=0.477 which mean IFN-γ +874 T/A gene was not related to recovered case of MDR-TB. The IL-10 -1082G/A gene obtained the value of OR=0.657 (0.173-2.491) and the value P=0.785 which means that IL-10 -1082G/A is not related to the MDR-TB case recovery.

Conclusions: There is no relationship of IFN-γ + 874T/A and IL-10 -1082G/A gene polymorphisms in the recovery of MDR-TB patients. (J Respir Indo. 2017; 37(4): 299-306)
Effect Of Nigella sativa Cement Extract on Procalcitonin, TNF-α Level and Time to Clinical Stable in Pneumonia Patients
Authors: Utami Lusiana Susilo , Reviono Reviono , Suradi Suradi , Harsini Harsini , Aphridasari Jatu
Published: April 2021

Background: Pneumonia is an infectious disease with highest morbidity and mortality in the world. The research objectives is to determine the effect of Nigella sativa cement extract in procalcitonin, TNF-α levels, and clinical improvement in pneumonia patients.
Methods: This study is a clinical trial quasi experimental design with pre and post test approach in the treatment group and the comparison group. Samples were taken by consecutive sampling between April and May 2016 a total of 30 patients were divided into 2 groups:the treatment group and the comparison group. The treatment group was given additional therapy capsules Nigella sativa cement extract, the comparison group was given the standard therapy. Procalcitonin levels and TNF-α is checked when the patient was admitted and when clinical improvement is achieved.
Results: Decreased levels of procalcitonin in the treatment group (8.969±13.591 ng/dl) and a comparison group (1.907±6293 ng/dl) was statistically significant (p= 0.014; 95 % CI= 0.222-1.770). Decreased levels of TNF-α was not significantly different between treatment groups (58.759(1.840-166.50) pg/dl) and a comparison group (57.485 (35.410-81.650) pg/dl), with p= 0.395. The achievement of clinical improvement in the treatment group 4.60±8.28 days and the comparison group 5.53 ±1.45 today, statistically no difference between the two groups.
Conclusion: Capsule Nigella sativa cement extract provides benefit for declining levels of procalcitonin and accelerate achievement of clinically stable in pneumonia patients. (J Respir Indo. 2017; 37(4): 316-24)
Effects of Green Tea to Absolute Neutrophil Count, MMP-9, %VEP1, and COPD Assessment Test Scores Stable COPD Patients
Authors: Apriningsih Hendrastutik , Suradi Suradi , Sutanto Yusup Subagio
Published: April 2021

Backgrounds: Chronic obstructive pulmonary disease is the leading cause morbidity and mortality worldwide. Cigarette smoke and noxious agent causing oxidative stress activated nuclear factor-κB then increase inflammatory genes releases. Epigallocatechin-3-gallate green tea have antiiinflammatory effect which can be use as addition therapy for stable COPD.
Methods: This study aimed to analyze the effect of EGCG to absolute neutrophil count (ANC), serum MMP-9, %FEV1, and CAT score stable COPD patients. Clinical trials of experimental with pre-test and post-test design was conducted on 30 patients in Dr. Moewardi Hospital Surakarta from February-April 2017. Samples were taken by consecutive sampling divided into treatment group (n=15) received standard therapy and green tea capsule 2x500mg/day during 28 days and control group received only standard therapy (n=15). Decreased inflammation measured by ANC and serum MMP-9, improvement of obstruction measured by %FEV1, and clinic improvement measured by CAT score.
Results: There were no significant differences (P=0.135) decrease ANC treatment group (-662.45±1446.80 µL) compared control (413.79±2292.90 µL), decrease serum MMP-9 (P=0.413) treatment group (-324.34±333.56 ng/ml) compared control (-181.21±577.52 ng/ml), %FEV1 (P=0.236) treatment group (2.56±10.77), compared control (-4.30±19.12), and significant difference (P=0.034) CAT score treatment group (-1.07±1.16) compared control (-0.20±1.08).
Conclusions: The addition of green tea capsule 2x500 mg/day during 28 days was significantly lowered CAT score, decreasing ANC, serum MMP-9 and increasing %FEV1 but not significant. (J Respir Indo 2018; 38(1): 7-15)
Correlation of Hemostatic Parameter with Lung Tumor Marker in Non-Small Cell Lung Cancer Patient with Chemotherapy
Authors: Samosir Ganda M. Leonard , Siagian Parluhutan , Eyanoer Putri Chairani
Published: April 2021

Backgrounds: There is a subclinical activation of coagulation and ﬁbrinolysis system in patient with lung cancer. Alterations in hemostatic system are seen frequently in lung cancer correlated with the prognosis of disease. In oncology practice, the use of tumor markers may be helpful in the diagnosis and pathologic classification of tumors. Tumor marker may reflect both, stage of the disease and prognosis. Aim of this research is to asses the correlation of this parameters in patient non-small cell lung cancer with chemotherapy.
Methods: This research is an analytic observational with a cross sectional design. The research was conducted at RSUP Haji Adam Malik, Medan from January 1, 2015 to May 31, 2016. Blood test examination was performed to measure the hemostatic parameter (PT, INR, APTT, TT, D-dimer) and serum tumor marker (CEA, Cifra21-1, NSE) of 41 non-small cell lung cancer patients before first cycle of chemotherapy and after fourth or sixth cycles of chemotherapy.
Results: The study comprised 41 patients of non-small cell lung cancer (31 adenocarcinoma, 10 squamous cell carcinoma), There were 35 men (85,4%) and 3 women (14,6%) with mean age of 56,7 years. For all patients, we give a platinum based therapy as first line chemotherapy (gemsitabine and carboplatin regimen in 27 patients, paclitaxel and carboplatin in 10 patients, vinorelbine and carboplatin in 4 patients). There is no significant difference of hemostatic parameter and serum tumors marker values before chemotherapy againts after chemotherapy values. And there is a weak negative correlation of hemostatic parameter againts serum tumor marker on non-small cell lung cancer patients with chemotherapy.
Conclusion: There is a weak negative correlation of hemostatic parameter againts serum tumor marker in non-small cell lung cancer patients with chemotherapy. (J Respir Indo 2018; 38(1): 33-38)
A Comparison of Aerobic Bacterial Culture between BAL and Induced Sputum Method on HIV-AIDS Patient with Bacterial Pneumonia CO-Infection
Authors: Marhana Isnin Anang , Sholeh Amir
Published: April 2021

Background: Bacterial pneumonia is the main cause of morbidity and mortality in immunocompromised individuals. The incidence of bacterial pneumonia on HIV patients is 2,3 cases per 100 people per year. On several cases, obtaining sputum sample for cultivation to confirm bacterial pneumonia diagnosis is difficult, thus further work to gain representative sample is necessary. This can be acquired through sputum induction and bronchoscopy. This study aims to compare aerobic bacteria culture result between BAL and induced sputum NaCl 3% method.
Method: This is a comparative analytical study which was done in UPIPI dr. Soetomo Hospital Surabaya on HIV-positive patients between 21 – 60 years old with suspected bacterial pneumonia through clinical and radiology findings. All patients went through sputum induction and BAL procedure. The sputum obtained was cultured aerobically to confirm the diagnosis of bacterial pneumonia.
Results: There were 26 subjects with average age 40 years old and male majority (73,1%). All patients were present with coughing and breahtlessness as their chief complaint, while the general complaint was coughing with difficulty in excreting sputum. The dominant risk factor is a history of free sex. The radiologic findings were dominated with unilateral infiltrate (73,1%). Most of the FOB imaging results were normal (88,5%). The results of aerobic bacterial culture from sputum induction are: Streptococcus pneumoniae (20%), Pseudomonas aeroginosa (20%), Acinetobacter spp. (20%), while from BAL method: Klebsiella pneumoniae (25%). The different specimen-obtaining method between induced sputum and BAL method has significant result with p= 0,001 (p
Correlation Between Copeptin and PSI with Intravenous to Oral Antibiotic Switch Theraphy and Length of Stay in Community-Acquired Pneumonia
Authors: Irawan Risky , Reviono Reviono , Harsini Harsini
Published: April 2021

Background: Pneumonia is a world’s health problem. AVP level in the circulation is difficult to measure therefore copeptin is chosen since
it is more comparable in number and more stable.
Method: Prospective observational study on 25 patients with community-acquired pneumonia in Dr.Moewardi Hospital from July-August 2017.
Result: There were no significant differences between switch therapy duration and length of stay to subject’s characteristic. There was a positive and significant correlation of PSI score to switch therapy and length of stay with a medium to strong correlation strength. Copeptin to switch therapy and length of stay had a positive and significant correlation with a medium to strong correlation strength. Pneumonia patients with PSI Score >90 had a risk of 36.67 times higher with switch therapy duration >4 days and it could be used as a predictor of switch therapy duration. Copeptin >17.23 with switch theraphy duration >4 days on pneumonia patient had a risk of 24.75 times higher and it could be used as a predictor of switch therapy duration. Pneumonia’s patient with PSI Score >100 with length of stay >10 days had a risk of 26.00 times higher and it could be used as a predictor of length of stay. Copeptin >27.39 with length of stay >10 days on pneumonia’s patient had a risk of 36.00 times higher and it could be used as a predictor of length of stay.
Conclusion: Both PSI Score and copeptin level had positive and significant correlation to switch theraphy and length of stay. (J Respir Indo 2019; 39(1): 44-53)
Hypercoagulation in Lung Cancer
Authors: Harlivasari Annisa Dian , Syahruddin Elisna
Published: April 2021

Hypercoagulation with a clinical manifestation of Venous Thromboembolism (VTE) is a frequent complication of malignancy whose incidence has increased markedly these recent years. The occurrence of VTE is likely to be triggered by multiple pathways dominated by tissue factor (TF). The VTE itself can directly lead to patient mortality and becoming the cause of death in cancer patients. Furthermore, emerging data suggest that activation of coagulation in malignancy is integrally linked with tumor biology, host associated and cancer treatment particularly with anti-angiogenesis. The clinical hypercoagulable state is linked with prognosis in patients with lung cancer, including patients receiving systemic chemotherapy. (J Respir Indo 2019; 39(2): 130-9)
The Effect of Ophiocephalus Striatus Extract on suPAR, Neutrophil Levels and Lung Diffusion Capacity (DLCO) in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients with Muscle Wasting
Authors: Nugroho Sasongko Adhi , Sartono Teguh Rahayu , Djajalaksana Susanthy , Rasyid Harun Al
Published: April 2021

Background: Muscle wasting is one of the extrapulmonary manifestation which influence quality of life in Chronic Obstructive Pulmonary Disease (COPD) patients. It caused by imbalance of protein metabolism in skeletal muscle. This study aimed to evaluate the effect of Ophiocephalus striatus extract on neutrophil count, soluble urokinase-type plasminogen activator (suPAR) level, diffusion capacity of lung for carbon monoxide (DLCO) and quality of life in stable COPD patients with muscle wasting.
Methods: Clinical pre and post quasi experimental study was conducted to 32 stable muscle-wasted COPD patients from Pulmonary Outpatient Clinic Saiful Anwar Hospital Malang, determined by The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016, Bioelectrical impedance analysis (BIA) dengan fat-free mass (FFM)
Correlation between Anxiety and Depression with Quality of Life among Chronic Obstructive Pulmonary Disease Patients
Authors: Mizarti Dessy , Herman Deddy , Sabri Yessy S , Yanis Amel
Published: April 2021

Background: Anxiety and depression among COPD patients can lead to physical limitation, lung function deterioration, risk of exacerbation and poor quality of life. This study aims to investigate correlation between anxiety and depression with quality of life among COPD patients Method: This was cross sectional analytic study recruiting COPD patients in Pulmonary outpatient setting in Dr. M. Djamil Central Hospital Padang and Achmad Mochtar Hospital Bukittinggi from January to March 2017. Samples were recruited through consecutive technique (accidental sampling). Result: Results showed from 101 COPD patients, average age was 65,54 + 9,99 years old. Mostly were male 83,17%, basic education 71,29%, low economical status 58,42%, married 81,19%, ex smoker 71,29%, severe Brinkman index 60,40%. There was correlation between gender (p value =0,002) and marital status (p value =0,010) with anxiety and or depression. Severe COPD patients tend to suffer from anxiety, depression, anxiety and depression, as many as 34,78%, 100% and 54,55%, respectively. Most COPD patients who suffered from anxiety and depression had poor quality of life 28,57%. There was correlation between anxiety and or depression with quality of life among COPD patients p-value= 0,005. COPD patients in D group often had poor quality of life 82,14%. There was correlation between COPD population group and quality of life (p-value=0,001). Conclusion: Anxiety and depression could occur in every stage of COPD, especially severe COPD. There was correlation between anxiety and or depression with quality of life so thus COPD treatment should embrace the comorbid factors. (J Respir Indo 2019; 39(2): 121-9)
The Prevalens of Ototoxicity in Drug Resistance Tuberculosis Patients and The Associated Factors at Persahabatan General Central Hospital
Authors: Rahmawati Ismulat , Isbaniah Fathiyah , Agustin Heidy , Sarikencana Raden Ena
Published: April 2021

Background: The treatment of drug resistance tuberculosis needs second line injection antituberculosis drug that associated with irreversible ototoxic. The aim of this study is to know the prevalence of ototoxicity in tuberculosis drug resistance patients and the contributing factors.
Methods: This is a cross sectional study among drug resistance TB patients who receive kanamysin or capreomycin as a part of drug regimen during intensive phase in January to September 2017 at Persahabatan hospital. Ototoxic defined according to American Speech Language and Hearing Association (ASHA) 1994 criteria by comparing baseline audiometric examination before treatment with current result.
Results: Seventy-two patients were included in this study. The prevalence of ototoxicity was found in 34 patients (47,2%). Ototoxic found in 5 subjects (14,7%) during the first month of treatment and 19 subjects (56%) without hearing disturbance complain. Ototoxic in kanamisin group (47,9%) is more frequent compared with capreomisin (36,8%). Ototoxicity was associated with age, the risk increases 5% every 1 year older p=0,029 aOR:1,050 IK95% (1,005-1,096). The prevalences of ototoxicity are higher in diabetes and increasing serum creatinin patients but statistically not significance. Sex, body mass index, the history of using injectable antiTB drug, HIV status and total dosis were not associated with ototoxicity.
Conclusion: Ototoxicity is common in intensive phase of drug resistance tuberculosis treatment. Further study needed to determine the association of contributing factors. (J Respir Indo. 2019; 39(3):180-95)
Urinary Cotinine and Expired CO Concentrations in Women Exposed to Environmental Tobacco Smoke at Home
Authors: Suryatama Herman , Fitriani Feni , Andarini Sita , Susanto Agus Dwi , Hudoyo Achmad
Published: April 2021

Introduction: The health effects of exposure to environmental tobacco smoke (ETS) using cotinine was a nicotine metabolite detected in urine. This should be recommended as a quantitative measurement of nicotine intake and as biomarker for ETS exposure in humans.
Method: We performed a cross-sectional study to 60 ETS-exposed and 58 non ETS exposed adult women in Pasar Rebo area, Jakarta. The urinary cotinine concentrations were measured and analyzed using ELISA method, other informations were collected such as expired CO data, questionnaire regarding smoking habits of the subjects’ family members at home and respiratory health effects occured to subjects.
Results: Median of urinary cotinine concentrations in ETS-exposed group were 24.65 ng/ml and 7.30 ng/ml in non-exposed group (P=0.0001). Median of expired CO in ETS-exposed group were 5.00 ppm and 3.00 ppm in non-exposed to ETS group (P=0.0001). Total amount of time (hours/day) in women exposed to ETS in their house was significantly correlated to urinary cotinine concentrations (P=0.037). The respiratory symptoms showed significant correlation with ETS exposure status (P=0.01). Time duration of last exposed to ETS had significant correlation with expired CO (P=0.004). The urinary cotinine concentrations cut-off point was 14.4 ng/ml (sensitivity=75%, specificity=74%, P=0.0001). The expired CO cut-off point was 3.5 ppm (sensitivity=75%, specificity=81%, p=0.0001). Strong and significant correlation was found between expired CO and urinary cotinine (r=0.641, P=0.0001).
Conclusion: The urinary cotinine and expired CO concentration were significantly higher in women exposed to tobacco smoke at home than the non-exposed group. Urinary cotinine measurement was a sensitive, non-invasive and effective method to correlate with ETS exposure. (J Respir Indo. 2019; 39(3):140-53)
Climate Caracteristic and Childhood Pneumonia: Systematic Review
Authors: Mas’udah Anni Fithriyatul , Pristya Terry Yuliana Rahadian
Published: April 2021

Backgrounds: Pneumonia is the leading cause of death in children worldwide. Pneumonia is the cause of mortality in an estimated of 922,000 children under age 5 in 2015, accounting for 15% of all deaths of children under five years old. The climatic conditions are complex and varied, had pneumonia a different impact in each country. The purpose of this study is to address the relationship between complications and childhood pneumonia.

Methods: This research was a systematic review of the study literature. The review method follows the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) checklist 2009. The number of articles that match the keywords is 254 articles and 8 articles that can be used.

Results: Seven of eight article's differences show the relationship between characteristics and pneumonia in children.

Conclusions: There is a relationship with the characteristics of pneumonia in children. (J Respir Indo. 2020; 40(1): 58-65)