bluuebunny/crossref_metadata_2025 huggingface dataset:
BRONCHOALVEOLAR LAVAGE FLUID STUDY FOR THE PRESENCE OF MALIGNANT CELLS IN PATIENTS WITH SUSPECTED LUNG CANCER IN MANIPUR
Authors: Ibungo Singh Irom , Reang Arabil , TV Swathi , Tongbram Christy , Mutum Anish , Rai Sabin
Published: July 2023

Introduction- Lung cancer is one of the common malignant neoplasms in the world. Although histopathology remains the gold standard for diagnosis, it is not possible to perform bronchial biopsies in all patients with suspicion of cancer. Cytological studies with bronchoalveolar lavage 1 (BAL) uid serves as a safe, economical and a quick diagnostic method of lung lesions . To examine BAL uid for the presence of Objectivesmalignant cells in patients with suspected lung cancer. This was a Methodology- cross sectional study performed on 118 cases of suspected lung cancer who attended Respiratory Medicine, Out Patient Department (OPD), Regional Institute of Medical Sciences (RIMS), Imphal, Manipur from September 2019 to August 2021. This study determined the presence of malignant ce Results- lls in 17.8% of the samples of BAL uid. Conclusion- Our study is one of the few studies that are available on utility of BAL uid analysis in detection of lung cancers. Among the malignant lesions diagnosed, squamous cell carcinoma was the most common cytological type and it was found to be signicantly more common among smokers when compared to non-smokers.
Nel silenzio della mia stanza… Riflessioni pedagogiche sul fenomeno Hikikomori
Authors: Certini Rossella , Distefano Christian
Published: July 2023

The category of Care, understood as an ontological construct of pedagogy, is a topic of research and in-depth study by many researchers for several reasons: for the importance it has in the epistemic framework of pedagogical science and for the centrality that this category has in educational practice. Talking about Care means to speak of a fundamental topical category today. The PRIN project Pratiche educative di prevenzione e ben-essere per gli Hikikomori. Dalla onsapevolezza alla “Cura educativa”, presented in 2022 and awaiting evaluation, sought to combine the category of Care with the educational emergency of the Hikikomori: they are young people locked inside their own room, who manifest their vulnerability by cancelling all kinds of relationships except the virtual one.
Analisis Blue Ocean Strategic Management Pada PT. Bank Jago
Authors: Andrealin Meilysa Grecia
Published: July 2023

Studi ini menganalisis penerapan strategi Blue Ocean oleh PT. Bank Jago, sebuah bank di Indonesia. Melalui metode penelitian deskriptif kualitatif dan pengumpulan data dari berbagai sumber, penelitian ini mengungkap beberapa temuan penting. Bank Jago telah mengadopsi pendekatan Blue Ocean Strategic Management untuk membedakan diri dari pesaing di pasar perbankan Indonesia. Mereka mengidentifikasi segmen pasar yang belum terpenuhi dan menciptakan layanan perbankan khusus untuk segmen tersebut. Bank Jago melakukan inovasi dengan memanfaatkan teknologi digital untuk memberikan pengalaman perbankan yang lebih baik kepada pelanggan. Mereka meluncurkan aplikasi perbankan berbasis mobile yang memungkinkan transaksi cepat dan mudah, serta menyediakan fitur analisis keuangan dan manajemen keuangan pribadi. Transformasi internal juga dilakukan oleh Bank Jago dalam budaya perusahaan dan struktur organisasi. Kolaborasi antardepartemen didorong, dan pendekatan yang lebih fleksibel dan adaptif diterapkan dalam pengambilan keputusan. Hal ini memungkinkan respons yang cepat terhadap perubahan pasar dan tantangan yang ada. Strategi Blue Ocean yang diadopsi oleh Bank Jago telah memberikan hasil positif, meningkatkan pangsa pasar dan pertumbuhan pendapatan dengan menarik pelanggan baru dan mempertahankan pelanggan yang ada. Secara keseluruhan, PT. Bank Jago berhasil menerapkan strategi Blue Ocean Strategic Management dengan sukses. Dengan inovasi, pemanfaatan teknologi, transformasi internal, dan fokus pada segmen pasar yang belum terpenuhi, mereka menciptakan keunggulan kompetitif yang membedakan mereka dari pesaing di industri perbankan. Penelitian ini memberikan wawasan berharga bagi perusahaan lain yang ingin mengadopsi pendekatan Blue Ocean dalam menghadapi persaingan ketat di pasar mereka.
TO THE QUESTION OF THE NEED FOR A NEW STATE POLICY OF FINANCIAL AND CREDIT RELATIONS
Authors: Rezbayev Vil M.
Published: July 2023

The article is devoted to the actual problems that exist in the modern world economy, the solution of which is aimed at a significant increase in the efficiency of its industries and the use of specific features, the development of a new state policy of financial and credit relations. The task is to substantiate that the achievement of the best results of labor in the financial and credit system of modern management is possible mainly due to the development of numerous factors in the activities of the relevant organizations, which are ultimately expressed in new technologies and new types of competitive products. Used content analysis of available sources, comparative analysis and statistics. It is shown that the introduction of new technical and organizational and technological solutions in the industries of production, the improvement of the basic principles of management in relation to the specifics of domestic producers will help create the necessary conditions for updating and improving the efficiency of labor processes in the industries of production. It is noted that in connection with this, at the turn of the 21st century, the problems of researching the latest financial policy of modern monetary regulation carried out by enterprises of the banking system have acquired great importance. It is concluded that the development of an effective financial policy of an enterprise involves the construction of the most appropriate system for managing the financial resources of an organization in order to achieve the goals of its functioning, which are expressed in maximizing profits, ensuring financial stability and investment attractiveness. It is noted that the formation of an effective financial policy of an enterprise should be based on a whole range of measures, in particular, on the use of tools for the redistribution and attraction of resources, as well as the prevention of possible risks.
PENGEMBANGAN MEDIA PEMBELAJARAN COMIC BERBASIS COMIC LIFE MATERI BENTUK-BENTUK ENERGI UNTUK MENDUKUNG MERDEKA BELAJAR SISWA KELAS IV SEKOLAH DASAR
Authors: Darniyanti Yulia , Aspialana  , Estuhono
Published: July 2023

Education is the process of a person developing all the abilities both intellectual and emotional, attitudes, and behaviors he has. Education can also be interpreted as the process of changing the attitudes and behaviors of a person or group of people with the aim of maturing through teaching media. Education is the main key in improving the quality of a nation. This research aims to create a comic learning media. This study uses the type of research and development (R &; D) this researcher uses the ADDIE model (analyze, design, dpelovment, implementation, and evaluation) the type of data taken in this study is quantative and qualitative data. The instruments used in this study are validation sheets, practicality sheets and effectiveness sheets. Data collection techniques used using observation techniques. Interviews and documentation. Data analysis in the form of validity analysis, practicality analysis and effectiveness analysis. The results of the validity of comic learning media assessed by validators amounted to 3 people, showing that comic learning media obtained a percentage of 85.83%. With a very valid category, comic learning media is suitable for use and in  accordance with the provisions of SD Negeri 04 Koto Baru. Practicality assessed from teacher response questionnaires and student response questionnaires to comic learning media obtained the following percentages: teacher response questionnaire 96% with very practical category, student response questionnaire 93.05% with very practical category, so based on the analysis of the teacher response questionnaire and student response questionnaire, it can be concluded that comic learning media is very practical for science learning in the SDN Negeri 04 koto baru class. The effectiveness assessed from the test question results obtained a percentage of 80% with the effectiveness category so that it can be said that using comic learning media is able to achieve learning objectives.
Odpowiedzialność karna i dyscyplinarna nauczyciela akademickiego za ten sam czyn – rozważania na temat zbiegu odpowiedzialności penalnej nauczyciela akademickiego
Authors: Łakomy Kamil
Published: July 2023

Przedmiotem artykułu jest analiza teoretycznych podstaw rozstrzygania zbiegu odpowiedzialności karnej i dyscyplinarnej nauczyciela akademickiego za ten sam czyn. Wobec braku jednoznacznego rozstrzygnięcia tej kwestii przez ustawodawcę, problemem badawczym jest pytanie o to czy wymierzenie odpowiedzialności karnej nauczycielowi akademickiemu za dany czyn, wyłącza odpowiedzialność zawodową. Rozważania przeprowadzone zostały w oparciu o systemowe uzasadnienie wprowadzenia odpowiedzialności dyscyplinarnej oraz teoretyczno-prawne koncepcje rozstrzygania jednoczynowego zbiegu odpowiedzialności penalnej. Wnioski analizy wskazują, że odpowiedzialność karna i dyscyplinarna realizują jakościowo inne cele, wobec czego zasadne jest przyjęcie tezy o ich niezależności w analizowanym obszarze.
 
The aim of the article is to analyse the theoretical basis for resolving the concurrence of criminal and disciplinary  liability of an academic teacher for a single act. In the absence of an explicit resolution of this issue by the legislature, the research problem is whether imposing criminal liability on an academic teacher for a given act excludes disciplinary liability. The analysis was carried out based on the systemic justification for introducing disciplinary liability and the theoretical legal concepts of resolving concurrent penal liability for a single act. The conclusions indicate that criminal and disciplinary responsibility pursue qualitatively different goals; thus, it is reasonable to assume that they are independent in this area.
Current role of machine learning and radiogenomics in precision neuro-oncology
Authors: Perillo Teresa , de Giorgi Marco , Papace Umberto Maria , Serino Antonietta , Cuocolo Renato , Manto Andrea
Published: July 2023

In the past few years, artificial intelligence (AI) has been increasingly used to create tools that can enhance workflow in medicine. In particular, neuro-oncology has benefited from the use of AI and especially machine learning (ML) and radiogenomics, which are subfields of AI. ML can be used to develop algorithms that dynamically learn from available medical data in order to automatically do specific tasks. On the other hand, radiogenomics can identify relationships between tumor genetics and imaging features, thus possibly giving new insights into the pathophysiology of tumors. Therefore, ML and radiogenomics could help treatment tailoring, which is crucial in personalized neuro-oncology. The aim of this review is to illustrate current and possible future applications of ML and radiomics in neuro-oncology.
Using Generative Adversarial Networks in Classification Tasks with Very Small Amounts of Training Data
Authors: Halmuratov Gofur , Veselý Arnošt
Published: July 2023

Deep learning algorithms are incredibly powerful and have achieved impressive results in various classification tasks. However, one of their limitations is their dependence on large amounts of training data. When there is limited training data available, the standard approach is to increase the dataset size by using data augmentation and training a neural network on the expanded dataset. This method can be effective, but it requires significant computational resources and may not always be feasible. In our work, we proposed a new approach to address the problem of limited training data. Instead of relying solely on increasing the dataset size, we train Generative Adversarial Networks (GANs) to generate distributions of individual categories. The classification of the unknown element is then performed using distributions generated by trained GAN networks. We proposed four methods that compare the unknown element with the elements generated by trained GAN networks and establish estimates of the conditional probabilities of the unknown element belonging to individual categories. These conditional probabilities are then used for the classification of the unknown element into individual categories. This approach enables us to make informed decisions and achieve accurate classification results even when dealing with limited training data.
HYDROCHEMICAL COMPARISON OF GROUNDWATER IN DIBBDIBA AND DAMMAM AQUIFERS IN THE KARBALA PLATEAU, CENTRAL IRAQ
Authors: Al-Kilabi Joudah A.
Published: July 2023

Fifty groundwater samples of water wells drilled in Karbala Plateau by the General Commission for Groundwater, twenty samples from Dibdibba and thirty from Dammam aquifers. The samples were anlaysed for major ions (Ca2+, Mg2+, Na+, K+, SO4 2+, Cl–, HCO3 –, and NO3 –), in addition to pH, EC and TDS. The aim of this study is to compare these aquifers hydrocamically and identify factors controlling their chemistry. Rock weathering is the main process affecting chemistry of Dammam groundwater in addition to cation exchange process. Evaporation process plays an important role influenced the chemical composition of groundwater in Dibdibba aquifer. The (Ca + Mg) SO4 and Na – (SO4 + Cl) are the predominant hydrochemical facies in Dibaiba and Dammam aquifers respectively. The alkaline water in some wells of Dibdibba aquifer may reflect the mixing with the Dammam aquifer.
A TEORIA DA LUA DE PIERRE-SIMON LAPLACE
Authors: Azevedo Herbert Wesley , Jesus Thiago
Published: July 2023

Apresenta-se neste trabalho uma tradução do artigo “Mémorie sur la théorie de la Lune” de Pierre-Simon Laplace. Publicado originalmente em 1800, em francês, perante o Institut national des Sciences et Arts e anexado posteriormente em 1802 ao volume III, livro VII, do Traité de mécanique céleste e republicado em edições posteriores das Oeuvres de Laplace a pedido do rei francês Louis Philippe I em 1842. O artigo de Laplace é reconhecido por utilizar o cálculo diferencial com elegância e possui inúmeras implicações na Astronomia, além de grande importância nos subsequentes trabalhos dele, tais como o estudo da forma do planeta Terra e o movimento da Lua.
PLANEJAMENTO DE CARREIRA EM MUSICOTERAPIA: ELABORANDO UM PLANO DE AÇÃO
Authors: Aires Filho Sergio Alexandre de Almeida , Anastácio Junior Mauro Pereira Amoroso
Published: July 2023

O objetivo deste artigoé promover uma reflexão sobre o planejamento de carreira do profissional musicoterapeuta no Brasil, apresentando uma sugestão de um plano de ações necessárias com metas estipuladas dentro do campo profissional. Também se pretendeapresentar um panorama sobre a consolidação da Musicoterapia no Brasil, passando pela Classificação Brasileira das Ocupações, Matriz DACUM, Musicoterapia no SUS, SUAS e nas Práticas Integrativas e Complementares. De forma geral, aponta-se a importância de o musicoterapeuta refletir sobre seu plano profissional, evitando a estagnação e a desatualização no que diz respeito à sua capacitação. Recomenda-se que estes assuntos sejam abordados nos cursos de graduação e pós-graduação em Musicoterapia.
An investigation of the relationship between mobile phone use in social media and college student anxiety
Authors: Fan Ziqiang
Published: July 2023

With the development of technology, the use of social platforms is becoming more and more common. People have very different views on social media, some think it is a good tool to help us maintain social interaction, while, others think that social media has too many negative effects that weigh out its positive effects. College students are a large part of the population that uses social media. In this paper, the author uses a literature study to investigate the previous literature and tries to find the relationship between college students' social media use and their anxiety level. The study aims to help the college student population address social anxiety-related issues. The results of the study did not find a strong positive or negative relationship between social media use and anxiety level among college students. However, the study found that the three negative effects of social media use did increase social anxiety levels among college students.
The Research on the Functions of Misleading on Suspense Setting -- Taking Hitchcock and the Psycho as Examples
Authors: Liu Zongheng
Published: July 2023

Hitchcock is considered as one of the most crucial film directors in history, since he has directed a series of successful suspense films and created many theories about them. Therefore, doing research on his film will help deepen the cognition in suspense movies in the field of movie studies. This article aims to explore Hitchcock’s suspense setting skills in film narratology. The author takes the Psycho, which is one of Hitchcock’s representative works as an example, and uses literature reading as well as some film theories to analyze the methods in suspense setting by Hitchcock. The article can be divided into four parts. The first part is the introduction. The second part is the introduction of Hitchcock and his Psycho. The third part shows analyses on Hitchcock’s suspense setting in Psycho. The last part is about Hitchcock’s effects on the following directors. Through the four parts’ analyses, the author discovered that Hitchcock’s suspense setting has a feature to use certain sounds or paintings to mislead the audience’s conjecture to the plot. The author calls this “misleading” and finds that there are still few system theories to describe it. The author makes some analyses about the misleading in suspense setting in Psycho in this article and hopes it can help following researchers when doing further research.
COVID-19, consequences on psychiatric care and access to mental health services: A patients’ opinions survey
Authors: Tempier Raymond , Bouattane El Mostafa , Tshiabo Muadi Delly , Abdulnour Joseph , Jacob Helena
Published: July 2023

Objective: The COVID-19 pandemic has (and will continue to have) quite a strong impact on patients whose mental conditions worsen due to isolation, disruption of usual routine, activities, and loss of community support, if not the infection itself. Therefore, exploring and evaluating existing ways and proposing new ways to communicate and maintain a strong therapeutic alliance between therapists and patients was important.Methods: A semi-structured interview based on a homemade grid designed to assess participants’ opinions on access to telehealth services and their efficiency. Period of study: March 2020 to June 2021.Results: Impact of COVID-19 on daily life: 70% experienced isolation due to the pandemic life-changing, 65% experienced anxiety, 42% depression, and 28% anger. Teleconsultations’ perceptions during the COVID-19 pandemic were perceived as a good solution for a pandemic era and no need for displacement (30%). 38% thought that video consultation is a better option than telephone consultations, with 60% stating a similar level of comfort in video/phone consultation compared to in-person. Recommendations to address Mental Health (MH) care delivery soon after this pandemic were: Patients (60%) are interested in accessing a website (or mobile application) on resources of MH services available in their city/region.Conclusions: Results show that isolation and anxiety were the factors most affecting the social life and conditions of participants, with some significant levels of depression and anger. Participants largely accepted the transition to virtual care with some improvements.
Model of Causal Relationship Affecting Value-oriented Marketing Strategy of Local Souvenirs in the Lower Northeastern Territory of Thailand
Authors: Ratree Umarin , Laksitamas Prin
Published: July 2023

: The survey and development research were designed to investigate the elements influencing the valueoriented marketing strategy of local souvenirs in Thailand's lower northeastern territory. Structural equation model analysis was used to statistically examine the data (SEM). According to the research findings, the value-oriented marketing strategy of local souvenirs was practically applicable at a high level (X = 4.420). The generated model on souvenirs was created consistently and fitly with empirical data, and the developed model had a good and acceptable degree of prediction at 92.70%. At a statistical significance of 0.05, the causal link revealed that the perceived value of local souvenirs, attitudes toward local souvenirs, and kinds of local souvenirs are related to the value-oriented marketing strategy of local souvenirs.
EFFECTIVE TEACHING BECOME A DETERMINER OF THE QUALITY OF A TEACHER
Authors: Nagata Zamzami
Published: July 2023

The educational process in schools is faced with the complexity and variety of student behavior in the learning process, the success of students in the learning environment even though it is influenced by the innate nature of individual students and their environment, but the teacher's role in learning becomes the most dominant focus of hope for student success in learning expected by all parties. Of course, based on these expectations, effective teaching skills in all respects are needed. Teachers must have knowledge of teaching materials from various perspectives, expertise in how to teach it, be professional in carrying out their teacher's duties, commitment and high motivation to pay attention to their students.
A nociva linguagem neoliberal na educação e as questões econômico-políticas
Authors: Furtado Filho Verissimo dos Santos , Alves Arlison Frank Lisboa
Published: July 2023

Com este artigo, tem-se por objetivo discutir a relação entre a educação e as questões econômico-políticas, com ênfase na influência da lógica neoliberal na concepção da aprendizagem delineada nos documentos oficiais sobre a educação básica, como a Lei de Diretrizes e Bases da Educação (LDB 9.394/1996) e a Base Nacional Comum Curricular (BNCC). Para tanto, são utilizadas as perspectivas de Michel Foucault e Christian Laval, cujas teorias proporcionam um arcabouço analítico abastado para entender como a pedagogia da aprendizagem e seus fundamentos neoliberais afetam a compreensão do indivíduo e da sociedade. Além disso, adota-se as concepções de Jorge Larrosa, que questiona o papel tradicionalmente atribuído à escola como salvadora do mundo, especialmente em um contexto marcado pela produção de mercadorias e lixo. Com este texto, pretende-se fazer um convite à reflexão sobre os sentidos e as experiências da atividade docente na atualidade. Nesse sentido, é fundamental compreender os desafios enfrentados pelos professores no atual panorama educacional, permeado por políticas neoliberais que enfatizam resultados quantitativos e competição. A análise crítica dessas tendências é essencial para repensar e reconfigurar práticas pedagógicas que considerem a formação integral dos estudantes, estimulando sua autonomia, criatividade e pensamento crítico.
School violence and class management
Authors: Balan Corina
Published: July 2023

This article addresses the issue of school violence from the perspective of the impact on student class manage-ment. In the context of student class management, student and teacher behaviours are influenced by several factors that make their mark on interlocutors’ relationships. Educational relationships determine positive or negative behavi-ours. Positive relationships generate a desirable atmosphere, and a constructive climate, while negative relationships generate an undesirable and conflicting environment, creating discipline problems. Discipline, seen as desirable behaviour in the classroom, can be defined as a process that determines the resolution of disciplinary problems and implicitly, the prevention and counteracting of students’ violent behaviour.
Career decision determinant of professional achievement
Authors: Cotruta Aida
Published: July 2023

A successful society, built on knowledge and the forming of new attitudes and skills, needs wide access to edu-cational and learning opportunities to face the social changes of the 21st century. Individual human potential has the capacity to adapt to new technologies and business needs, and is essential for a competitive and dynamic economy, taking into account personal educational background. These aspects must take account of scientific and technological progress, which places new requirements and quality training in front of everyone. The choice of training areas is often strongly shaped by social and parental influences. These influences are due to parental status, intra-familial emotional ties or inter-school relationships, which become important factors and deter-mine their resonance and impact on career choice. The latter try to influence the beneficiary’s career decision, often based on arguments founded on lived experiences. In this way, the conscious career decision comes with the maturity of the beneficiary, which reflects personal disposition to make the right decisions in reference to vocational training
Nivel de conocimiento, actitudes y practicas sobre la prueba de Papanicolaou en mujeres de 18 a 59 años en la urbanización Albino Herrera del callao en el periodo 2020
Authors:   , Aguilar Mendoza Wendy Fiorella
Published: July 2023

Objetivo: Determinar el nivel de conocimiento, actitudes y prácticas sobre la prueba de Papanicolaou en mujeres de 18 a 59 años en la Urbanización Albino Herrera del Callao en el periodo 2020. Metodología: Estudio observacional, descriptivo, transversal y prospectivo mediante encuesta validada por juicio de expertos, a 194 mujeres de 18 a 59 años en la Urbanización Albino Herrera del Callao en el periodo 2020, se procesaron los datos en Excel 2016 y SPSS 24. Resultados: Se obtuvo que 57.2% de mujeres tienen un nivel de conocimiento alto acerca de la prueba de Papanicolaou, asimismo un 72.7% poseían una actitud favorable y que el 58.8% realizaban prácticas inadecuadas. Conclusiones: El nivel de conocimiento de las féminas de esta investigación acerca del Papanicolaou fue alto y tenían actitudes favorables; sin embargo, sus prácticas eran inadecuadas a pesar de que la mayoría de las encuestadas si se habían realizado la prueba anteriormente al menos una vez.
Análisis de la seguridad jurídica de los contratos electrónicos establecida en la Ley N° 29571, provincia de Chincha, 2021-2022
Authors:   , Mendoza Cerna Luciana Isabel
Published: July 2023

Para el desarrollo de la presente investigación que lleva como título: “Análisis de la seguridad jurídica de los contratos electrónicos establecida en la ley N° 29571, Provincia de chincha, 2021-2022 “, fue necesario especificar temas de gran importancia respecto a los contratos electrónicos, como es analizar doctrinariamente la celebración de contratos, en la constitución política de 1993 y la legislación civil, así como describir desde el punto de vista constitucional, la regulación sobre el derecho de los consumidores, además, analizar según la doctrina, la celebración de los contratos electrónicos, asimismo, la ley N° 29571. El presente trabajo tiene como objetivo general analizar los argumentos jurídicos, para incorporar en el ordenamiento civil peruano e identificar si se brinda al consumidor la seguridad jurídica que requiere para celebrar los contratos electrónicos. Para la metodología fue necesario utilizar técnicas como son las encuestas, donde se formuló 20 preguntas dirigidos a 25 usuarios y a 25 estudiantes de derecho, de esta manera el presente trabajo concluye con lo siguiente, los contratos electrónicos se encuentran escasamente legislados de una manera bastante general, ya que no es suficiente ni brinda seguridad jurídica, existe un vacío en la normatividad, en cuanto a la regulación de estos. Finalmente, la presente investigación es de gran importancia, pues se identificará el nivel de protección en seguridad jurídica que tienen los consumidores al momento de realizar contratos electrónicos, para que así mismos ellos puedan tomar precauciones y evitar que sus derechos de consumidores sean vulnerados.
Suspensión perfecta de labores y el derecho al trabajo en la empresa Lima Caucho durante el estado de emergencia COVID 19 - 2020
Authors:   , Montes Ayala Julio Ruben
Published: July 2023

La presente investigación titulada “SUSPENSIÓN PERFECTA DE LABORES Y EL DERECHO AL TRABAJO EN LA EMPRESA LIMA CAUCHO DURANTE EL ESTADO DE EMERGENCIA COVID 19 – 2020” tuvo como objetivo determinar si la suspensión perfecta de labores afectó el derecho al trabajo en la empresa Lima Caucho durante el estado de emergencia Covid 19 - 2020, siendo que el problema de investigación tiene por fundamento que no se afecte el derecho al trabajo / o dicho derecho laboral y otros conexos con el uso de la suspensión perfecta de labores. En el marco metodológico, se empleó procedimientos propios de las investigaciones con enfoque cualitativo, de tipo aplicada - descriptiva, de nivel teórico práctico, el diseño de estudio fue no experimental de corte transversal, cuya muestra representativa de la población fue 40 conformado por trabajadores de la empresa Lima Caucho, trabajadores del Juzgado de Trabajo zona 03 de Santa Anita y abogados especialistas en derecho laboral, y en el análisis de los datos se empleó el método hipotético deductivo. Una vez presentado los resultados se ha llegado concluir que la suspensión perfecta de labores si afectó el derecho al trabajo en la empresa Lima Caucho durante el estado de emergencia Covid 19 – 2020.
Metal‐Free One‐Pot Tandem Construction of C4‐Phosphorylated Phthalazin‐1(2H)‐ones under Visible‐Light Photoredox Catalysis
Authors: Yao Zhen , Liu Xiongwei , Liu Chang , Pan Bowen , Shi Yang , Feng Tingting , Zhou Ying , Xu Lijin
Published: July 2023

Visible‐light photoredox‐catalyzed metal‐free one‐pot tandem regioselective synthesis of C4‐phosphorylated phthalazin‐1(2H)‐ones from arylhydrazines, 2‐formylbenzoic acids with diarylphosphine oxides is described. This three‐component transformation occurs smoothly under mild conditions, providing regiospecific access to various phosphorylated products in 73–91% yield. The efficacy of the current catalysis arises from the use of organic 1,2,3,5‐tetrakis(carbazol‐9‐yl)‐4,6‐dicyanobenzene (4CzIPN) as the photocatalyst and cheap K2S2O8 as the oxidant.
Anomalous Charge Transfer from Organic Ligands to Metal Halides in Zero‐Dimensional [(C6H5)4P]2SbCl5 Enabled by Pressure‐Induced Lone Pair‐π Interaction
Authors: Luo Hui , Bu Kejun , Yin Yanfeng , Wang Dong , Shi Cuimi , Guo Songhao , Fu Tonghuan , Liang Jiayuan , Liu Bingyan , Zhang Dongzhou , Xu Liang‐Jin , Hu Qingyang , Ding Yang , Jin Shengye , Yang Wenge , Ma Biwu , Lü Xujie
Published: July 2023

Low‐dimensional (low‐D) organic metal halide hybrids (OMHHs) have emerged as fascinating candidates for optoelectronics due to their integrated properties from both organic and inorganic components. However, for most of low‐D OMHHs, especially the zero‐D (0D) compounds, the inferior electronic coupling between organic ligands and inorganic metal halides prevents efficient charge transfer at the hybrid interfaces and thus limits their further tunability of optical and electronic properties. Here, using pressure to regulate the interfacial interactions, efficient charge transfer from organic ligands to metal halides is achieved, which leads to a near‐unity photoluminescence quantum yield (PLQY) at around 6.0 GPa in a 0D OMHH, [(C6H5)4P]2SbCl5. In situ experimental characterizations and theoretical simulations reveal that the pressure‐induced electronic coupling between the lone‐pair electrons of Sb3+ and the π electrons of benzene ring (lp‐π interaction) serves as an unexpected “bridge” for the charge transfer. Our work opens a versatile strategy for the new materials design by manipulating the lp‐π interactions in organic–inorganic hybrid systems.
Korrektur der absoluten Konfiguration von Chelocardin und Amidochelocardin
Authors: Sikandar Asfandyar , Popoff Alexander , Jumde Ravindra P. , Mándi Attila , Kaur Amninder , Elgaher Walid A. M. , Rosenberger Lara , Hüttel Stephan , Jansen Rolf , Hunter Maja , Köhnke Jesko , Hirsch Anna K. H. , Kurtán Tibor , Müller Rolf
Published: July 2023

Selbst mit Hilfe modernster Techniken ist die Bestimmung der absoluten Konfiguration von Naturstoffen eine anspruchsvolle und fehleranfällige Herausforderung. Dementsprechend gibt es auch Fälle, in denen die Stereochemie nach einer Totalsynthese oder einer Kristallstrukturanalyse (XRD) korrigiert werden muss. In diesem Artikel korrigieren wir die absolute Konfiguration von Amidochelocardin auf Basis einer Kombination aus XRD, NMR, ECD‐Spektroskopie und time‐dependent density‐functional theory (TDDFT)‐ECD‐Berechnungen. Da Amidochelocardin aus einer genetisch veränderten Chelocardin‐Biosynthese stammt, ist eine identische Stereochemie naheliegend. Die Ergebnisse von TDDFT‐ECD‐Berechnungen unterstützen diese Vermutung. Zusätzlich konnte die Analyse der Spektren von zwei strukturell verwandten Analoga, 6‐Desmethyl‐Chelocardin (6‐DMCHD) und dem semisynthetischen Derivat 1 von 6‐DMCHD diese Hypothese bestätigen.
Bottom‐up Synthesis of Single‐Crystalline Poly (Triazine Imide) Nanosheets for Photocatalytic Overall Water Splitting
Authors: Wang Qian , Zhang Guigang , Xing Wandong , Pan Zhiming , Zheng Dandan , Wang Sibo , Hou Yidong , Wang Xinchen
Published: July 2023

Poly (triazine imide) (PTI/Li+Cl−), one of the crystalline versions of polymeric carbon nitrides, holds great promise for photocatalytic overall water splitting. In principle, the photocatalytic activity of PTI/Li+Cl− is closely related to the morphology, which could be reasonably tailored by the modulation of the polycondensation process. Herein, we demonstrate that the hexagonal prisms of PTI/Li+Cl− could be converted to hexagonal nanosheets by adjusting the binary eutectic salts from LiCl/KCl or NaCl/LiCl to ternary LiCl/KCl/NaCl. Results reveal that the extension of in‐plane conjugation is preferred, when the polymerisation was performed in the presence of ternary eutectic salts. The hexagonal nanosheets bears longer lifetimes of charge carriers than that of hexagonal prisms due to lower intensity of structure defects and shorter hopping distance of charge carriers along the stacking direction of triazine nanosheets. The optimized hexagonal nanosheets exhibits a record apparent quantum yield value of 25 % (λ=365 nm) for solar hydrogen production by one‐step excitation overall water splitting.
Implementation of an Industrial Automation Remote Lab (IARL) and validation using a deep learning approach during the COVID pandemic
Authors: Sekaran Julius Fusic , Hildas Ramesh
Published: July 2023

The purpose of this study is to demonstrate a novel remote lab development for improving student psychomotor skills in the Industry 4.0 course. In this work, the vision and Internet of Things‐based lab setup for third‐year undergraduates is proposed as Industrial Automation Remote Lab (IARL). The major motivation of this novel approach is to replicate Industry 4.0 in the laboratory for learning purposes to undergraduate students during pandemic condition. In industries, it is essential to collect all the data from the machines to make optimal use of resources and increase the efficiency of the system. The stored data are interfaced through the user datagram protocol to control the speed of the hydraulic actuator. In the proposed experimental work, a vision sensor‐based anydesk remote control software technique is employed to conduct programmable logic circuit (PLC) experiments. To collect the various output image data sets, numerous PLC experiments were conducted. The collection of images is classified to investigate the student performance using deep learning algorithms like YOLOv4, VGG, and YOLOv5. Based on the simulation and validation results, the IARL‐based approach with YOLOv5 outperforms the other two algorithms with 98% accuracy. Additionally, the validated statistical internal and external results show that the remote laboratory Conceive, Design, Implement, and Operate (CDIO) batch performance is highly improved over virtual laboratory CDIO batch students.
NAC1 confines virus‐specific memory formation of CD4+ T cells through the ROCK1‐mediated pathway
Authors: Wang Liqing , Peng Hao‐Yun , Kishore Das Jugal , Kumar Anil , Ren Yijie , Ballard Darby J. , Xiong Xiaofang , Yang Wen , Ren Xingcong , de Figueiredo Paul , Yang Jin‐Ming , Song Jianxun
Published: July 2023

Nucleus accumbens‐associated protein 1 (NAC1), a transcriptional cofactor, has been found to play important roles in regulating regulatory T cells, CD8+ T cells, and antitumor immunity, but little is known about its effects on T‐cell memory. In this study, we found that NAC1 expression restricts memory formation of CD4+ T cells during viral infection. Analysis of CD4+ T cells from wild‐type (WT) and NAC1‐deficient (−/−) mice showed that NAC1 is essential for T‐cell metabolism, including glycolysis and oxidative phosphorylation, and supports CD4+ T‐cell survival in vitro. We further demonstrated that a deficiency of NAC1 downregulates glycolysis and correlates with the AMPK‐mTOR pathway and causes autophagy defective in CD4+ T cells. Loss of NAC1 reduced the expression of ROCK1 and the phosphorylation and stabilization of BECLIN1. However, a forced expression of ROCK1 in NAC1−/− CD4+ T cells restored autophagy and the activity of the AMPK‐mTOR pathway. In animal experiments, adoptively transferred NAC1−/− CD4+ T cells or NAC1−/− mice challenged with VACV showed enhanced formation of VACV‐specific CD4+ memory T cells compared to adoptively transferred WT CD4+ T cells or WT mice. This memory T‐cell formation enhancement was abrogated by forcing expression of ROCK1. Our study reveals a novel role for NAC1 as a suppressor of CD4+ T‐cell memory formation and suggests that targeting NAC1 could be a new approach to promoting memory CD4+ T‐cell development, which is critical for an effective immune response against pathogens.
A Mucin‐Based Bio‐Ink for 3D Printing of Objects with Anti‐Biofouling Properties
Authors: Rickert Carolin A. , Mansi Salma , Fan Di , Mela Petra , Lieleg Oliver
Published: July 2023

With its potential to revolutionize the field of personalized medicine by producing customized medical devices and constructs for tissue engineering at low costs, 3D printing has emerged as a highly promising technology. Recent advancements have sparked increasing interest in the printing of biopolymeric hydrogels. However, owing to the limited printability of those soft materials, the lack of variability in available bio‐inks remains a major challenge. In this study, a novel bio‐ink is developed based on functionalized mucin—a glycoprotein that exhibits a multitude of biomedically interesting properties such as immunomodulating activity and strong anti‐biofouling behavior. To achieve sufficient printability of the mucin‐based ink, its rheological properties are tuned by incorporating Laponite XLG as a stabilizing agent. It is shown that cured objects generated from this novel bio‐ink exhibit mechanical properties partially similar to that of soft tissue, show strong anti‐biofouling properties, good biocompatibility, tunable cell adhesion, and immunomodulating behavior. The presented findings suggest that this 3D printable bio‐ink has a great potential for a wide range of biomedical applications, including tissue engineering, wound healing, and soft robotics.
A millimeter‐wave broadband power amplifier with a tree‐like transistor structure using 0.15‐μm GaAs technology
Authors: Guo Letian , Huang Wenhua , Wang Yujia , Wu Tianxiang , Ma Shunli , Ren Junyan
Published: July 2023

In this paper, a millimeter‐wave broadband high‐efficiency power amplifier (PA) for Ka‐band (26–32 GHz) using 0.15‐μm GaAs pseudomorphic high‐electron‐mobility transistor process is proposed. The PA utilizes a three‐stage cascade structure and adopts an RC series feedback network, which expands the bandwidth and ensures the circuit stability. To improve the output power and efficiency of the circuit, a tree‐like transistor structure is proposed. The power amplifier, it can provide 23.6 dBm output P1dB with 33.1% power‐added efficiency at 28 GHz with high linearity. The maximum small signal gain can reach 27 dB with 3‐dB bandwidth from 24 to 33 GHz for the measured results.
Dirichlet process mixture models using matrix‐generalized half‐t distribution
Authors: Lee Sanghyun , Kim Chanmin
Published: July 2023

Dirichlet process mixture models (or mixture of Dirichlet process [MDP]) are Bayesian non‐parametric mixture models that can solve the problem of determining the number of components in mixture models by assuming infinitely many components. We propose a new approach for MDP by using a matrix‐generalized half‐
distribution as a non‐informative prior for the covariance in the base distribution. This new approach aims to improve the performance of MDP in cases where conjugacy constraints cause underperformance of current priors, such as Wishart distribution or inverse‐Wishart. The effectiveness of this approach is demonstrated through simulations and by comparing its performance on the Old Faithful geyser dataset with existing MDP specifications.
Synthesis and Crystal Structures of Three Thioether Functionalized Lithium Silylamides
Authors: Liebing Phil , Schatz Philipp , Merzweiler Kurt
Published: July 2023

A series of three lithium silylamides Li2Me2Si(NC6H4‐2‐SR)2 (R=Me, Ph, tBu) were prepared from the reaction of the corresponding silylamines Me2Si(NH‐C6H4‐2‐SR)2 with n‐butyl lithium. X‐ray single crystal structure analyses revealed the formation of dimers [Li4{Me2Si(NC6H4‐2‐SR)2}2] with Si2N4Li4 hetero‐adamantane cores. Recrystallisation of [Li4{Me2Si(NC6H4‐2‐SMe)2}2] and [Li4{Me2Si(NC6H4‐2‐SPh)2}2] from diethyl ether led to the formation of the adducts [Li4(Et2O)2{Me2Si(NC6H4‐2‐SMe)2}2] and [Li4(Et2O){Me2Si(NC6H4‐2‐SPh)2}2]. In the case of the SMe derivative the addition of two diethyl ether molecules led to a rearrangement of the Si2N4Li4 core to give a double decker structure and in contrast the hetero adamantane structure is retained in the diethyl ether adduct of the SPh derivative.
Slow Down, Move Over: A Case Study in Formal Verification, Refinement, and Testing of the Responsibility-Sensitive Safety Model for Self-Driving Cars
Authors: Strauss Megan , Mitsch Stefan
Published: July 2023

Technology advances give us the hope of driving without human error, reducing vehicle emissions and simplifying an everyday task with the future of self-driving cars. Making sure these vehicles are safe is very important to the continuation of this field. In this paper, we formalize the Responsibility-Sensitive Safety model (RSS) for self-driving cars and prove the safety and optimality of this model in the longitudinal direction. We utilize the hybrid systems theorem prover KeYmaera X to formalize RSS as a hybrid system with its nondeterministic control choices and continuous motion model, and prove absence of collisions. We then illustrate the practicality of RSS through refinement proofs that turn the verified nondeterministic control envelopes into deterministic ones and further verified compilation to Python. The refinement and compilation are safety-preserving; as a result, safety proofs of the formal model transfer to the compiled code, while counterexamples discovered in testing the code of an unverified model transfer back. The resulting Python code allows to test the behavior of cars following the motion model of RSS in simulation, to measure agreement between the model and simulation with monitors that are derived from the formal model, and to report counterexamples from simulation back to the formal model.
A test instance generator for multiobjective mixed-integer optimization
Authors: Eichfelder Gabriele , Gerlach Tobias , Warnow Leo
Published: July 2023

Application problems can often not be solved adequately by numerical algorithms as several difficulties might arise at the same time. When developing and improving algorithms which hopefully allow to handle those difficulties in the future, good test instances are required. These can then be used to detect the strengths and weaknesses of different algorithmic approaches. In this paper we present a generator for test instances to evaluate solvers for multiobjective mixed-integer linear and nonlinear optimization problems. Based on test instances for purely continuous and purely integer problems with known efficient solutions and known nondominated points, suitable multiobjective mixed-integer test instances can be generated. The special structure allows to construct instances scalable in the number of variables and objective functions. Moreover, it allows to control the resulting efficient and nondominated sets as well as the number of efficient integer assignments.
Water speciation and hydrogen isotopes in hydrous stishovite: implications for the deep Earth water cycle
Authors: Kueter Nico , Brugman Kara , Miozzi Francesca , Cody George D. , Yang Jing , Strobel Timothy A. , Walter Michael J.
Published: July 2023

Stishovite is a key mineral for understanding the deep Earth water cycle because of its potential as a main carrier for water into the transition zone and lower mantle. During subduction-related metamorphism of basaltic oceanic crust, stishovite stabilizes at 8–9 GPa and comprises 10–25 vol% of the bulk mineralogy, with some experimental studies indicating that stishovite can accommodate 3.5 wt% H2O or more in the transition zone and upper lower mantle. This large water solubility has been explained by a hydrogarnet substitution mechanism (1Si4+ ↔ 4H+) and/or the incorporation of interstitial molecular water. To investigate water speciation and hydrogen isotope behavior, we synthesized partially deuterated hydrous stishovite at 9 GPa and 450 °C in a multi-anvil press (MA). The hydrous stishovite contains on average 1.69 ± 0.05 wt% water, which is consistent with earlier MA studies but is significantly lower than the 3.5 wt% reported from in situ diamond anvil cell (DAC) studies made at higher pressures and temperatures. 1H MAS NMR spinning sideband characteristics suggest a high abundance of interstitial molecular water in hydrous stishovite, while the presence of a hydrogarnet defect cannot be ruled out. Unit-cell volumes and deuterium enrichment in the quenched hydrous stishovite indicate that ~ 45% of the water is lost from the stishovite upon quenching and decompression of the experiment, consistent with a higher solubility. This implies that the pristine water contents of a P–T–fO2 equilibrated hydrous stishovite cannot be quenched to 1 atm and room temperature from classical MA experiments. We further present a capillary-based recovery method for fluid from experimental capsules, allowing direct determination of the D/H ratio of the experimental fluid and indirect determination of the hydrous stishovite. Using Rayleigh modeling to account for the quench-related water loss, we find that, at 450 °C and 9 GPa, deuterium is 3.5–4.5 times enriched in hydrous stishovite relative to coexisting aqueous fluid. This is opposite of what is commonly observed for mineral–fluid pairs above 300 °C, rendering hydrous stishovite a potential sink for deuterium and decreasing the D/H ratio of coexisting aqueous fluids. Partial decomposition (30–60%) of hydrous stishovite during mantle upwelling and production of primary basaltic melts could be accompanied by high-temperature D/H fractionation, decreasing the hydrogen isotope composition of such melts towards “mantle-like” δD values between −75 and −220‰.