bluuebunny/crossref_metadata_2025 huggingface dataset:
HOXA4, down-regulated in lung cancer, inhibits the growth, motility and invasion of lung cancer cells
Authors: Cheng Shaofei , Qian Fengying , Huang Qin , Wei Lirong , Fu Yawen , Du Yuzhen
Published: April 2018

The involvement of HOXA4 in colorectal cancer and epithelial ovarian cancer has been reported. Although it has been reported that the Hoxa4 gene is involved in the patterning of the mouse lung during embryonic development, little is known about the biological functions of HOXA4 in lung cancer. In the current study, HOXA4 expression was down-regulated in lung cancer tissues when compared with non-cancerous tissues. HOXA4 expression was associated with tumor size, TNM stage, lymph node metastasis and prognosis. Bioinformatics analysis revealed that HOXA4 expression was negatively correlated with cell cycle, metastasis, and the Wnt signaling pathway. Moreover, HOXA4 overexpression in lung cancer cell lines suppressed cell proliferation, migration, and invasion. HOXA4 decreased the protein expression levels of β-catenin, Cyclin D1, c-Myc and Survivin, indicating the inhibition of Wnt signaling. HOXA4 significantly increased the protein and mRNA levels of glycogen synthase kinase-3β (GSK3β) by promoting its transcription. Furthermore, inhibition of GSK3β by LiCl abolished the suppression of cell growth, migration, and invasion mediated by HOXA4. Overexpression of HOXA4 in xenograft tumors also decreased tumor growth and Wnt signaling. Collectively, these data suggest that HOXA4 is a potential diagnostic and prognostic marker in lung cancer, and its overexpression could inhibit lung cancer progression in part by promoting GSK3β transcription.
Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway
Authors: Feng Hao , Li Ziyu , Du Juan , Sun Jing , Feng Wei , Li Dongfang , Liu Shanshan , Wang Wei , Liu Hongrui , Amizuka Norio , Li Minqi
Published: April 2018

Lipopolysaccharide (LPS)-induced osteoblast apoptosis is a prominent factor to the defect in periodontal tissue repair in periodontal disease. LPS challenge contributes to the production of reactive oxygen species (ROS) in periodontitis, and peroxiredoxin 1 (Prx1) is an antioxidant protein that protect cells against oxidative damage from ROS. Without LPS stimulation, apoptotic rates were higher in both Prx1 knockout (Prx1KO) and Prx1 overexpression (Prx1OE) cells compared with wild type. After LPS stimulation, intracellular ROS in Prx1KOcells showed the highest level and Prx1OEcells showed the least. Treatment with LPS significantly elevated the expression of Bax, Cyto-c, and caspase 3 in Prx1KOcells compared with wild type, although this could be completely abolished by NAC. In Prx1OEcells, the expression and activation of ASK1 were significantly increased, and this was slightly reduced by LPS stimulation. NQDI-1 completely abolished the increased phosphorylation of JNK and p38 and the expression of caspase 3 in LPS-stimulated cells. These results indicate that Prx1 eliminates intracellular ROS and exhibits a cytoprotective role in LPS-induced apoptosis. However, under physiological conditions, Prx1 overexpression acts as a H2O2messenger, triggering the expression of ASK1 and its downstream cascades.
Interplay of cell death signaling pathways mediated by alternating magnetic field gradient
Authors: Wong De Wei , Gan Wei Liang , Teo Yuan Kai , Lew Wen Siang
Published: April 2018

The ability to control or manipulate the pathways leading to cell death plays a pivotal role in cancer treatment. We demonstrate magneto-actuation of magnetic nanoparticles (MNPs) to induce different cell death signaling pathways, exemplifying the intricate interplay between apoptosis and necrosis. In vitro cell experiments show the cell viabilities decreases with increasing field strength and is lower in cells treated with low aspect ratio MNPs. In a strong vertical magnetic field gradient, the MNPs were able to apply sufficient force on the cell to trigger the intracellular pathway for cell apoptosis, thus significantly reducing the cell viability. The quantification of apoptotic and necrotic cell populations by fluorescence dual staining attributed the cell death mechanism to be predominantly apoptosis in a magnetic field gradient. In contrast, the MNPs in an alternating magnetic field gradient can effectively rupture the cell membrane leading to higher lactate dehydrogenase leakage and lower cell viability, proving to be an effective induction of cell death via necrosis.
Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation
Authors: Taki Mana , Abiko Kaoru , Baba Tsukasa , Hamanishi Junzo , Yamaguchi Ken , Murakami Ryusuke , Yamanoi Koji , Horikawa Naoki , Hosoe Yuko , Nakamura Eijiro , Sugiyama Aiko , Mandai Masaki , Konishi Ikuo , Matsumura Noriomi
Published: April 2018

Snail is a major transcriptional factor that induces epithelial-mesenchymal transition (EMT). In this study, we explore the effect of Snail on tumor immunity. Snail knockdown in mouse ovarian cancer cells suppresses tumor growth in immunocompetent mice, associated with an increase of CD8+ tumor-infiltrating lymphocytes and a decrease of myeloid-derived suppressor cells (MDSCs). Snail knockdown reduces the expression of CXCR2 ligands (CXCL1 and CXCL2), chemokines that attract MDSCs to the tumor via CXCR2. Snail upregulates CXCR ligands through NF-kB pathway, and most likely, through direct binding to the promoters. A CXCR2 antagonist suppresses MDSC infiltration and delays tumor growth in Snail-expressing mouse tumors. Ovarian cancer patients show elevated serum CXCL1/2, which correlates with Snail expression, MDSC infiltration, and short overall survival. Thus, Snail induces cancer progression via upregulation of CXCR2 ligands and recruitment of MDSCs. Blocking CXCR2 represents an immunological therapeutic approach to inhibit progression of Snail-high tumors undergoing EMT.
The Ustilago maydis repetitive effector Rsp3 blocks the antifungal activity of mannose-binding maize proteins
Authors: Ma Lay-Sun , Wang Lei , Trippel Christine , Mendoza-Mendoza Artemio , Ullmann Steffen , Moretti Marino , Carsten Alexander , Kahnt Jörg , Reissmann Stefanie , Zechmann Bernd , Bange Gert , Kahmann Regine
Published: April 2018

To cause disease in maize, the biotrophic fungus Ustilago maydis secretes a large arsenal of effector proteins. Here, we functionally characterize the repetitive effector Rsp3 (repetitive secreted protein 3), which shows length polymorphisms in field isolates and is highly expressed during biotrophic stages. Rsp3 is required for virulence and anthocyanin accumulation. During biotrophic growth, Rsp3 decorates the hyphal surface and interacts with at least two secreted maize DUF26-domain family proteins (designated AFP1 and AFP2). AFP1 binds mannose and displays antifungal activity against the rsp3 mutant but not against a strain constitutively expressing rsp3. Maize plants silenced for AFP1 and AFP2 partially rescue the virulence defect of rsp3 mutants, suggesting that blocking the antifungal activity of AFP1 and AFP2 by the Rsp3 effector is an important virulence function. Rsp3 orthologs are present in all sequenced smut fungi, and the ortholog from Sporisorium reilianum can complement the rsp3 mutant of U. maydis, suggesting a novel widespread fungal protection mechanism.
The State of the World’s Beaches
Authors: Luijendijk Arjen , Hagenaars Gerben , Ranasinghe Roshanka , Baart Fedor , Donchyts Gennadii , Aarninkhof Stefan
Published: April 2018

Coastal zones constitute one of the most heavily populated and developed land zones in the world. Despite the utility and economic benefits that coasts provide, there is no reliable global-scale assessment of historical shoreline change trends. Here, via the use of freely available optical satellite images captured since 1984, in conjunction with sophisticated image interrogation and analysis methods, we present a global-scale assessment of the occurrence of sandy beaches and rates of shoreline change therein. Applying pixel-based supervised classification, we found that 31% of the world’s ice-free shoreline are sandy. The application of an automated shoreline detection method to the sandy shorelines thus identified resulted in a global dataset of shoreline change rates for the 33 year period 1984–2016. Analysis of the satellite derived shoreline data indicates that 24% of the world’s sandy beaches are eroding at rates exceeding 0.5 m/yr, while 28% are accreting and 48% are stable. The majority of the sandy shorelines in marine protected areas are eroding, raising cause for serious concern.
Thymol nanoemulsion exhibits potential antibacterial activity against bacterial pustule disease and growth promotory effect on soybean
Authors: Kumari Sarita , Kumaraswamy R. V. , Choudhary Ram Chandra , Sharma S. S. , Pal Ajay , Raliya Ramesh , Biswas Pratim , Saharan Vinod
Published: April 2018

An antibacterial and plant growth promoting nanoemulsion was formulated using thymol, an essential oil component of plant and Quillaja saponin, a glycoside surfactant of Quillaja tree. The emulsion was prepared by a sonication method. Fifty minutes of sonication delivered a long term stable thymol nanoemulsion which was characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), cryogenic-field emission scanning electron microscopy (Cryo-FESEM) and fourier transform infra-red (FTIR) spectroscopy. Creaming index, pH and dilution stability were also studied for deliberation of its practical applications. The nanoemulsion (0.01–0.06%, v/v) showed substantial in vitro growth inhibition of Xanthomonas axonopodis pv. glycine of soybean (6.7-0.0 log CFU/ml). In pot experiments, seed treatment and foliar application of the nanoemulsion (0.03–0.06%, v/v) significantly lowered the disease severity (DS) (33.3–3.3%) and increased percent efficacy of disease control (PEDC) (54.9–95.4%) of bacterial pustule in soybean caused by X. axonopodis pv. glycine. Subsequently, significant enhancements of plant growth were also recorded in plants treated with thymol nanoemulsion. This is the first report of a thymol based nanoemulsion obtained using Quillaja saponin as a surfactant. Our study claims that nano scale thymol could be a potential antimicrobial and plant growth promoting agent for agriculture.
Relationships between digestive efficiency and metabolomic profiles of serum and intestinal contents in chickens
Authors: Beauclercq Stéphane , Nadal-Desbarats Lydie , Hennequet-Antier Christelle , Gabriel Irène , Tesseraud Sophie , Calenge Fanny , Le Bihan-Duval Elisabeth , Mignon-Grasteau Sandrine
Published: April 2018

The increasing cost of conventional feedstuffs has bolstered interest in genetic selection for digestive efficiency (DE), a component of feed efficiency, assessed by apparent metabolisable energy corrected to zero nitrogen retention (AMEn). However, its measurement is time-consuming and constraining, and its relationship with metabolic efficiency poorly understood. To simplify selection for this trait, we searched for indirect metabolic biomarkers through an analysis of the serum metabolome using nuclear magnetic resonance (1H NMR). A partial least squares (PLS) model including six amino acids and two derivatives from butyrate predicted 59% of AMEn variability. Moreover, to increase our knowledge of the molecular mechanisms controlling DE, we investigated1H NMR metabolomes of ileal, caecal, and serum contents by fitting canonical sparse PLS. This analysis revealed strong associations between metabolites and DE. Models based on the ileal, caecal, and serum metabolome respectively explained 77%, 78%, and 74% of the variability of AMEn and its constitutive components (utilisation of starch, lipids, and nitrogen). In our conditions, the metabolites presenting the strongest associations with AMEn were proline in the serum, fumarate in the ileum and glucose in caeca. This study shows that serum metabolomics offers new opportunities to predict chicken DE.
Development of a Click-Chemistry Reagent Compatible with Mass Cytometry
Authors: Shaklee Jessica , Srivastava Kriti , Brown Heather , Arriaga Edgar A. , Pierre Valerie C. , van Berlo Jop H.
Published: April 2018

The recent development of mass cytometry has allowed simultaneous detection of 40 or more unique parameters from individual single cells. While similar to flow cytometry, which is based on detection of fluorophores, one key distinguishing feature of mass cytometry is the detection of atomic masses of lanthanides by mass spectrometry in a mass cytometer. Its superior mass resolution results in lack of signal overlap, thereby allowing multiparametric detection of molecular features in each single cell greater than that of flow cytometry, which is limited to 20 parameters. Unfortunately, most detection in mass cytometry relies on lanthanide-tagged antibodies, which is ideal to detect proteins, but not other types of molecular features. To further expand the repertoire of molecular features that are detectable by mass cytometry, we developed a lanthanide-chelated, azide-containing probe that allows click-chemistry mediated labeling of target molecules. Following incorporation of the thymidine analog 5-ethynyl-2′-deoxyuridine (EdU) during DNA synthesis in S-phase of the cell cycle, we demonstrate that the probe introduced here, tagged with Terbium-159 (159Tb), reacts via copper-catalyzed azide-alkyne Huisgen cycloaddition (click-chemistry) with Edu. Thus, detection of 159Tb makes it possible to measure DNA synthesis in single cells using mass cytometry. The approach introduced here shows similar sensitivity (true positive rate) to other methods used to measure DNA synthesis in single cells by mass cytometry and is compatible with the parallel antibody-based detection of other parameters in single cells. Due to its universal nature, the use of click-chemistry in mass cytometry expands the types of molecular targets that can be monitored by mass cytometry.
Acceptability, tolerability, and potential efficacy of cognitive behavioural therapy for Insomnia Disorder subtypes defined by polysomnography: A retrospective cohort study
Authors: Miller Christopher B. , Espie Colin A. , Bartlett Delwyn J. , Marshall Nathaniel S. , Gordon Christopher J. , Grunstein Ronald R.
Published: April 2018

In this retrospective cohort study, we describe acceptability, tolerability and potential efficacy of cognitive behavioural therapy (CBT) in Insomnia Disorder subtypes, derived from polysomnography (PSG): insomnia with normal-sleep duration (I-NSD) and insomnia with short-sleep duration (I-SSD). All research volunteers were offered access to digital CBT, single component sleep restriction therapy and face-to-face group CBT. Follow-up occurred at three months post-treatment using the insomnia severity index (ISI). 96 participants (61 females, mean age of 41 years) were grouped into either normal-sleep (n = 53) or short-sleep (n = 43). CBT was acceptable to 63% of participants (normal-sleep = 31, short-sleep = 29), with 28 completing therapy (tolerability: normal-sleep = 11, short-sleep = 17). For potential efficacy, 39 (normal-sleep = 20, short-sleep = 19) out of 96 participants (41%) completed a follow-up ISI assessment. In this reduced sample, mean (SD) ISI scores decreased across both groups (normal-sleep: 18.0 (4.0) to 10.7 (4.6); short-sleep: 16.5 (5.5) to 11.0 (6.3); both P < 0.01). Those with normal-sleep were more likely to respond (≥6-point ISI reduction) to CBT compared to short-sleep (70%, n = 14/20 vs. 37%, n = 7/19 respectively, P = 0.038). In this cohort, 60 (63%) of participants attempted CBT and of those 28 (47%) completed therapy. Results may be comparable to clinical participants with implications for the successful translation of CBT for insomnia.
Dietary patterns and chronic kidney disease: a cross-sectional association in the Irish Nun Eye Study
Authors: Paterson Euan N. , Neville Charlotte E. , Silvestri Giuliana , Montgomery Shannon , Moore Evelyn , Silvestri Vittorio , Cardwell Christopher R. , MacGillivray Tom J. , Maxwell Alexander P. , Woodside Jayne V. , McKay Gareth J.
Published: April 2018

Associations between dietary patterns and chronic kidney disease are not well established, especially in European populations. We conducted a cross-sectional study of 1033 older Irish women (age range 56–100 years) with a restricted lifestyle. Dietary intake was assessed using a food frequency questionnaire. Renal function was determined by estimated glomerular filtration rate. Two dietary patterns were identified within the study population using factor analysis. A significant negative association was found between unhealthy dietary pattern adherence and renal function in both unadjusted and adjusted models controlling for potential confounding variables (p for trend <0.001), with a mean difference in estimated glomerular filtration rate of −6 ml/min/1.73 m2 between those in the highest fifth of adherence to the unhealthy dietary pattern compared to the lowest, in the fully adjusted model. Chronic kidney disease risk was significantly greater for the highest fifth, compared to the lowest fifth of unhealthy dietary pattern adherence in adjusted models (adjusted odds ratio = 2.62, p < 0.001). Adherence to the healthy dietary pattern was not associated with renal function or chronic kidney disease in adjusted models. In this cohort, an unhealthy dietary pattern was associated with lower renal function and greater prevalence of chronic kidney disease.
Interaction of the GntR-family transcription factor Sll1961 with thioredoxin in the cyanobacterium Synechocystis sp. PCC 6803
Authors: Kujirai Junichi , Nanba Sato , Kadowaki Taro , Oka Yoshiki , Nishiyama Yoshitaka , Hayashi Yuuki , Arai Munehito , Hihara Yukako
Published: April 2018

Changes in the redox state of the photosynthetic electron transport chain act as a signal to trigger acclimation responses to environmental cues and thioredoxin has been suggested to work as a key factor connecting the redox change with transcriptional regulation in the cyanobacteriumSynechocystissp. PCC 6803. We screened for redox-dependent transcription factors interacting with thioredoxin M (TrxM) and isolated the GntR-type transcription factor Sll1961 previously reported to be involved in acclimation responses of the photosynthetic machinery. Biochemical analyses using recombinant Sll1961 proteins of wild type and mutants of three cysteine residues, C124, C229 and C307, revealed that an intramolecular disulfide bond is formed between C229 and C307 under oxidizing conditions and TrxM can reduce it by attacking C307. Sll1961 exists in a dimeric form of about 80 kDa both under reducing and oxidizing conditions. C124 can form an intermolecular disulfide bond but it is not essential for dimerization. Based on these observations, tertiary structure models of the Sll1961 homodimer and the Sll1961-TrxM complex were constructed.
Transmission events revealed in tuberculosis contact investigations in London
Authors: Cavany Sean M. , Vynnycky Emilia , Sumner Tom , Macdonald Neil , Thomas H. Lucy , White Jacqui , White Richard G. , Maguire Helen , Anderson Charlotte
Published: April 2018

Contact tracing is a key part of tuberculosis prevention and care, aiming to hasten diagnosis and prevent transmission. The proportion of case-contact pairs for which recent transmission occurred and the typical timespans between the index case and their contact accessing care are not known; we aimed to calculate these. We analysed individual-level TB contact tracing data, collected in London from 20/01/2011-31/12/2015, linked to tuberculosis surveillance and MIRU-VNTR 24-locus strain-typing information. Of pairs of index cases and contacts diagnosed with active tuberculosis, 85/314 (27%) had strain typing data available for both. Of these pairs, 79% (67/85) shared indistinguishable isolates, implying probable recent transmission. Of pairs in which both contact and the index case had a social risk factor, 11/11 (100%) shared indistinguishable isolates, compared to 55/75 (75%) of pairs in which neither had a social risk factor (P = 0.06). The median time interval between the index case and their contact accessing care was 42 days (IQR: 16, 96). As over 20% of pairs did probably not involve recent transmission between index case and contact, the effectiveness of contact tracing is not necessarily limited to those circumstances where the index case has transmitted disease to their close contacts.
Rylene annulated phthalocyanine: a fully conjugated block for the construction of a supramolecular two-dimensional framework
Authors: Feng Jiajing , Fu Lulu , Huang Tengda , Geng Hua , Jiang Wei , Wang Zhaohui
Published: April 2018

A rylene annulated phthalocyanine was designed with a quasi-planar “four leaf clover” skeleton and a two-dimensional cage-like supramolecular structure.
Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein–Ru(carbene) adduct
Authors: Sullivan Matthew P. , Nieuwoudt Michél K. , Bowmaker Graham A. , Lam Nelson Y. S. , Truong Dianna , Goldstone David C. , Hartinger Christian G.
Published: April 2018

The first crystallographic study of a Ru(carbene)–protein adduct is complemented by EPR spectroscopy showing Ru oxidation upon binding.
Quantum anomalous/valley Hall effect and tunable quantum state in hydrogenated arsenene decorated with a transition metal
Authors: Zhang Tian , Mu Yi , Zhao Jian-Zhou , Hu Cui-E , Chen Xiang-Rong , Zhou Xiao-Lin
Published: April 2018

The QAH effect in TM@AsH and its relationship with band inversion caused by the competition between SOC and the exchange field are found.
Phase transition in amphiphilic poly(N-isopropylacrylamide): controlled gelation
Authors: Li Bin , Thompson Mark E.
Published: April 2018

Amphiphilic random poly(N-isopropylacrylamide) copolymers are found to form a hydrogel which is highly elastic, stable, thermo-reversible and self-healable.
ZnMn2O4 nanorods: an effective Fenton-like heterogeneous catalyst with t2g3eg1 electronic configuration
Authors: Qiu Maoqin , Chen Zhangxian , Yang Zeheng , Li Wenming , Tian Yuan , Zhang Weixin , Xu Yishu , Cheng Hansong
Published: April 2018

The t2g3eg1 electron configuration of Mn benefits the Fenton-like spinel ZnMn2O4 nanorod catalyst by promoting the creation of oxygen-containing radicals.
Structure–function relationship during CO2 methanation over Rh/Al2O3 and Rh/SiO2 catalysts under atmospheric pressure conditions
Authors: Martin Natalia M. , Hemmingsson Felix , Wang Xueting , Merte Lindsay R. , Hejral Uta , Gustafson Johan , Skoglundh Magnus , Meira Debora Motta , Dippel Ann-Christin , Gutowski Olof , Bauer Matthias , Carlsson Per-Anders
Published: April 2018

Intermediate species formed during CO2 methanation over Rh/Al2O3 and Rh/SiO2 catalysts.
Laminated pyroelectric generator with spin coated transparent poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) electrodes for a flexible self-powered stimulator
Authors: Jiang Weitao , Zhao Tingting , Liu Hongzhong , Jia Rui , Niu Dong , Chen Bangdao , Shi Yongsheng , Yin Lei , Lu Bingheng
Published: April 2018

A laminated pyroelectric generator with spray coated transparent PEDOT:PSS electrodes has been designed for use as a flexible self-powered stimulator.
Enhancing performance of Ag–ZnO–Ag UV photodetector by piezo-phototronic effect
Authors: Zhang Xiaotong , Qiu Yu , Yang Dechao , Li Bing , Zhang Heqiu , Hu Lizhong
Published: April 2018

An ultraviolet photodetector based on a ZnO nanowires with metal–semiconductor–metal Schottky structure was fabricated on a flexible polyester fibre substrate.
Efficient removal of hexavalent chromium from water by an adsorption–reduction mechanism with sandwiched nanocomposites
Authors: Liu Weikang , Yang Liang , Xu Shihao , Chen Yao , Liu Bianhua , Li Zhong , Jiang Changlong
Published: April 2018

A sandwiched nanocomposite has been developed to remove hexavalent chromium ion Cr(vi) from water by an adsorption–reduction mechanism.
Selective catalytic amination of halogenated aldehydes with calcined palladium catalysts
Authors: Villa Alberto , Dumoleijn Kim , Evangelisti Claudio , Moonen Kristof , Prati Laura
Published: April 2018

This work focuses on understanding the influence of the conditions used in the calcination step of palladium catalysts on the performance of this catalyst in the reductive amination of halogen-containing substrates.
Magnetically targeted co-delivery of hydrophilic and hydrophobic drugs with hollow mesoporous ferrite nanoparticles
Authors: Xu Chao , Yu Suchun , Liu Langlang , Wu Xiaopei , Dai Honglian
Published: April 2018

A magnetically targeted drug delivery system (DDS) is developed to solve the delivery problem of hydrophobic drugs by using hollow mesoporous ferrite nanoparticles (HMFNs).
Transition metal triflate catalyzed conversion of alcohols, ethers and esters to olefins
Authors: Keskiväli J. , Parviainen A. , Lagerblom K. , Repo T.
Published: April 2018

In this work, we report an efficient solvent-free metal triflate catalyzed conversion of various biomass-based alcohols, ethers and esters to olefins.
A bifunctional electrolyte additive for H2O/HF scavenging and enhanced graphite/LiNi0.5Co0.2Mn0.3O2 cell performance at a high voltage
Authors: Zhou Rong , Huang Jianxing , Lai Shaobo , Li Jiyang , Wang Feng , Chen Zhiqiang , Lin Weiqing , Li Chao , Wang Jing , Zhao Jinbao
Published: April 2018

A novel strategy for selecting additives is adopted and a bifunctional additive is investigated for H2O/HF-scavenging and enhanced cell performance.
Complex hydrides as thermal energy storage materials: characterisation and thermal decomposition of Na2Mg2NiH6
Authors: Humphries Terry D. , Sheppard Drew A. , Li Guanqiao , Rowles Matthew R. , Paskevicius Mark , Matsuo Motoaki , Aguey-Zinsou Kondo-Francois , Sofianos M. Veronica , Orimo Shin-ichi , Buckley Craig E.
Published: April 2018

The thermodynamic properties of Na2Mg2NiH6have been investigated to determine feasibility as a thermal energy storage material.
Construction of uniform transition-metal phosphate nanoshells and their potential for improving Li-ion battery performance
Authors: Zhang Dong , Hu Lin-Lin , Sun Yong-Gang , Piao Jun-Yu , Tao Xian-Sen , Xu Yan-Song , Cao An-Min , Wan Li-Jun
Published: April 2018

The construction of uniform core–shell nanostructures using transition-metal phosphates as the shell has been a long-standing challenge in the field of nanotechnology.
2D porous carbon nanosheets constructed using few-layer graphene sheets by a “medium-up” strategy for ultrahigh power-output EDLCs
Authors: Chang Panpan , Matsumura Kazuki , Zhang Jizong , Qi Jie , Wang Chengyang , Kinumoto Taro , Tsumura Tomoki , Chen Mingming , Toyoda Masahiro
Published: April 2018

2D porous carbon nanosheets (PCNs) occupy the foreground in the field of electric double-layer capacitors (EDLCs).
Amino N-oxide functionalized graphene quantum dots as a cathode interlayer for inverted polymer solar cells
Authors: Zhang Lu , Xu Han , Ding Zicheng , Hu Junli , Liu Jun , Liu Yichun
Published: April 2018

A non-ionic graphene derivative, amino N-oxide functionalized graphene quantum dots, is developed and used as a cathode interlayer for inverted polymer solar cells.
Clinical characteristics and prognosis of multiple myeloma with bone-related extramedullary disease at diagnosis
Authors: Tian Chen , Wang Lu , Wu Ling , Zhu Lei , Xu Wengui , Ye Zhaoxiang , Zhao Zhigang , Wang Yafei , Zhang Yizhuo
Published: April 2018

Multiple myeloma (MM) is a hematological neoplasm which results in diffuse or focal bone infiltration and extramedullary lesions. It’s reported that infiltration of organs by plasma cells indicated worse prognosis, but the prognosis of patients with bone-related extramedullary disease (bEMD) is still unknown. One hundred and fourteen newly diagnosed MM patients were retrospectively reviewed. Results showed that the clinical features, overall survival (OS), and progression-free survival (PFS) of patients with and without bEMD had no statistical significance. Rib (46.1%) and vertebrae (17.9%) are common sites bEMD involved. Patients with diffuse bEMD had worse prognosis compared with patients with focal bEMD. Bisphosphonates played an important role in prolonging the survival of patients with bEMD. Positron emission tomography (PET)/computed tomography (CT) is sensitive in discovering bEMD than whole body low dose CT suggesting PET/CT to be a promising technique for initial staging. High β2-microglobulin and low albumin indicated shorter survival in patients with bEMD.
A simple quantum generator of random numbers
Authors: Roussille Hugo , Djadaojee Lionel , Chevy Frédéric
Published: April 2018

Cryptography techniques rely on chains of random numbers used to generate safe encryption keys. Since random number generator algorithms are in fact pseudo-random their behavior can be predicted if the generation method is known and as such they cannot be used for perfectly safe communications. In this article, we present a perfectly random generator based on quantum measurement processes. The main advantage of such a generator is that using quantum mechanics, its behavior cannot be predicted in any way. We verify the randomness of our generator and compare it to commonly used pseudo-random generators.
Geographic Information System for Higher Education via Data Scrapping
Authors: Alfiansyah Agung , Azhar Anas
Published: April 2018

This paper aims to build a database that can be used as the most important part of a geographic information system by using data from reliable sources. Data collection is done through process scrapping on some official website of Indonesia government. In addition to collecting quantitative data of higher education, this paper also mapping geographically from the high level of existing in Indonesia. It is expected that this data will be able to help the community and government in observing and analyzing the quantity and distribution of universities. The result of this research is one database that is ready to be integrated in more complex geographic information system. In addition, the scrapping method used allows us to perform the upgrade of data that has been obtained previously.
Information System Strategic Planning for Department of Housing and Settlement Region in the Jakarta Provincial Government - Indonesia
Authors: Sembodo Suroso Jarot , Harisno  , Mauritsius Tuga , Setyawan Agung
Published: April 2018

This research was conducted in the Unit Pengelola Rumah Susun—UPRS (Flats Manager Unit) in Jakarta Provincial Government and based on the existence of problems strategic planning of information systems. The purpose of this study is to provide a proposal of Information System Strategy and Management Information System for UPRS. The strategic planning of the information systems on research was conducted using the method of Ward and Peppard. The IS strategic planning in the UPRS which is proposed in this research is hope to be used to integrate each business process and IS system which is connected to the Jakarta Smart City. IS is needed with the competent human resources to manage the IS/IT of the UPRS to increase the service quality to the flat occupants and to increase the employees productivity in implementing their job functions.
Development of Presentation Model with Cloud Based Infrastructure
Authors: Magdalena Widiantari Maria , Budiman Arief
Published: April 2018

Computer mediated communication are the communication activities using technology which have rapidly in progress. Communication interactive activities nowadays has no longer only involving person to person but mediated by technology, and have been done in many fields including in education and teaching activity. In this study, presentation media based on cloud's infrastructure designed to replace face to face or in class lectures. In addition, the presentation will allow media data storage indefinitely, and accessible wherever and anytime. This is in line with the concept of student center learning where students were encouraged to more active in the lecture activities. The purpose of this research is making or designing a presentation model based on cloud‘s infrastructure. This research is using research and development method which is consists of four stages, where the first phase is composing the concept of media presentation design. The second phase are choosing the subject that will be designed as the subject of presentation. The third stage is designing presentation model. And the fourth phase is collecting materials of the subject that will be presented by each lecturer.
Design and Development of Smart Aquaculture System Based on IFTTT Model and Cloud Integration
Authors: Dzulqornain Muhammad Iskandar , Harun Al Rasyid M. Udin , Sukaridhoto Sritrusta
Published: April 2018

The internet of things technology (IoT) is growing very rapidly. IoT implementation has been conducted in several sectors. One of them is for aquaculture. For the traditional farmers, they face problems for monitoring water quality and the way to increase the quality of the water quickly and efficiently. This paper presents a real-time monitoring and controlling system for aquaculture based on If This Then That (IFTTT) model and cloud integration. This system was composed of smart sensor module which supports modularity, smart aeration system for controlling system, local network system, cloud computing system and client visualization data. In order to monitor the water condition, we collect the data from smart sensor module. Smart sensor module consists of sensor dissolved oxygen, potential of hydrogen, water temperature and water level. The components of smart aeration system are microcontroller NodeMCU v3, relay, power supply, and propeller that can produce oxygen. The system could set the IFTTT rules for the ideal water condition for the pond in any kinds of aquaculture based on its needs through the web and android application. The experimental result shows that use IFTTT model makes the aquaculture monitoring system more customizable, expandable and dynamic.
The Importance of Credit Program Scheme on Waste to Energy Program in Indonesia: Case Study on Tofu Industry
Authors: Syaifudin Noor , Nurkholis  , Handika Rangga , Hendroko Setyobudi Roy
Published: April 2018

This study aimed to provide a basis for future policy making in supporting the waste to energy from tofu in Indonesia. The policy studied was the credit program scheme for tofu industry. The financial feasibility, as well as cost and benefit analysis, were conducted to meet the objectives. Tofu industries are mostly small-sized industry which supports people with middle-to-low incomes. On the other hand, tofu industry also contributes significant amounts of emissions. Thus this calls for government intervention to encourage tofu industries to convert their wastes to energy. The result of the study shows that the developments of biogas reactors are feasible for size 84 m3 and 94 m3. The study also found that for both sizes, the benefits are higher than the costs.
Formulating Interest Subsidy Program to Support the Development of Electricity Generation from Palm Oil Mill Effluent (POME) Biomass: An Indonesian Case Study
Authors: Syaifudin Noor , Nurkholis  , Handika Rangga , Hendroko Setyobudi Roy
Published: April 2018

This paper analyses financial feasibility and cost-benefit and formulates the relevant subsidy program that is currently implemented by the government. We find that providing interest subsidy is financially feasible only if it serves to substitute the consumption of diesel. The benefits are higher than the costs among three types (45 t, 60 t and 75 t) of the palm waste generator capacity. The paper also reveals that Credit Program is relevant with the objective, to provide interest subsidy to farmers, but certain adaptations are required.
Biomass and Sugar Content of Some Varieties of Sorghum (Sorghum Bicolor L. Moench) on Dry Land Forest as Feedstock Bioethanol
Authors: Gamawati Adinurani Praptiningsih , Rahayu Sri , Sulistiyo Budi Luluk , Nindita Anggi , Soni Peeyush , Mel Maizirwan
Published: April 2018

The possibility of sustainable use of sorghum as raw material for bioethanol needs to be supported by evaluation and selection of sorghum varieties for high biomass production and sugar content. An experiment was conducted on forest dry land , altitude 63 m asl. This research aimed to determine the interaction of sorghum varieties and mycorrhiza on biomass production and the high sugar content. The experiment was a two factor (varieties and dosage of mycorrhiza plus) in a randomized complete block design with three replications. The varieties were Suri 3, Kawali, Super 2, Suri 4. Dosage of mycorrhiza plus (5, 10, 15) g per plant. The interaction only significant on a number of internodes and bagasse. There are no effects of dosages mycorrhiza plus, however, varieties of sorghum have significant effects on many variables measured. The highest amount of biomass include the stem height (301.28 cm), stem Dry Weight (DW) is 23.48 t ha-1, leaf DW (4.65 t ha-1), panicle DW (11.35 t ha-1) and biomass DW (39.98 t ha-1) were obtained in varieties Super 2. Sugar content (16.93 %) was obtained in varieties Suri 3 and juice production (2 742.86 L ha-1) in varieties Suri 4.
Effect of Cryogenic Treatment on Micro-structure and Properties of Different Polymer Materials
Authors: Ni Hongjun , Zhuo Lu , Gu Hai , Lv Shuaishuai , Zhu Yu , Shi Chongshi , Wang Xingxing
Published: April 2018

In order to improve the mechanical properties of the polymer materials, three kinds of samples with the same size were manufactured by the 3D printing equipment. And the materials were polycarbonate, ABS and polypropylene, respectively. After -190°C+8h cryogenic treatment, the mechanical properties such as wear resistance and hardness were tested and the functional groups and internal molecule chain changes were observed by Fourier transform infrard spectrometer. The results showed that the mechanical properties of polymer materials can be improved effectively after the cryogenic treatment. Compared with the untreated samples, the hardness of the PC, ABS and PP samples increased by 27.6%, 10.8% and 20.3% respectively. Among the three materials, the wear resistance of ABS material was improved obviously.
Neural Network Optimized Model Predictive Multi-Objective Adaptive Cruise Control
Authors: Zhang Siyi , Zhang Junzhi
Published: April 2018

A model predictive multi-objective adaptive cruise control (MPC MO-ACC) system, designed to consider both the tracking performance and the fuel consumption, is optimized by a neural network in this paper, reducing the computational complexity without sacrificing the control performance. The optimized MO-ACC control system is built by training a neural network with the control results of the MPC MO-ACC system. Simulation tests are conducted in Matlab/Simulink in conjunction with the high-fidelity CarMaker software. Influences of four driving conditions (the learning track, NEDC, JP05, FTP75) and two kinds of sensor models (ideal radar sensor and 77GHz physical radar sensor) are analysed. Simulation results have shown that the neural network optimized model predictive MO-ACC has the same control capability and strong robustness as the original MPC MO-ACC. Meanwhile, the optimized control system has much lower computational complexity, which shows potentials for the application in real-time vehicle control and industry.
Estimation of Vehicle Side-Slip Angle Using an Artificial Neural Network
Authors: Chindamo Daniel , Gadola Marco
Published: April 2018

In this work, a reliable and effective method to predict the vehicle side-slip angle is given by means of an artificial neural network. It is well known that artificial neural networks are a very powerful modelling tool. They are largely used in many engineering fields to model complex and strongly non-linear systems. For this application, the network has to be as simple as possible in order to work in real-time within built-in applications such as active safety systems. The network has been trained with the data coming from a custom manoeuvre designed in order to keep the method simple and light from the computational point of view. Therefore, a 5-10-1 (input-hidden-output layer) network layout has been used. These aspects allow the network to give a proper estimation despite its simplicity. The proposed methodology has been tested by means of the CarSim® simulation package, which is considered one of the reference tools in the field of vehicle dynamics simulation. To prove the effectiveness of the method, tests have been carried out under different adherence conditions.
Modular Estimation Strategy of Vehicle Dynamic Parameters for Motion Control Applications
Authors: Rawash Mustafa , Abdelaziz Mohamed , Ghoneima Maged , Tolbah Farid
Published: April 2018

The presence of motion control or active safety systems in vehicles have become increasingly important for improving vehicle performance and handling and negotiating dangerous driving situations. The performance of such systems would be improved if combined with knowledge of vehicle dynamic parameters. Since some of these parameters are difficult to measure, due to technical or economic reasons, estimation of those parameters might be the only practical alternative. In this paper, an estimation strategy of important vehicle dynamic parameters, pertaining to motion control applications, is presented. The estimation strategy is of a modular structure such that each module is concerned with estimating a single vehicle parameter. Parameters estimated include: longitudinal, lateral, and vertical tire forces – longitudinal velocity – vehicle mass. The advantage of this strategy is its independence of tire parameters or wear, road surface condition, and vehicle mass variation. Also, because of its modular structure, each module could be later updated or exchanged for a more effective one. Results from simulations on a 14-DOF vehicle model are provided here to validate the strategy and show its robustness and accuracy.
Road Bank Angle Estimation for Three Wheel Tilting Vehicle Using Multi Model Estimator
Authors: Jeong Kicheol , Choi Seibum
Published: April 2018

In recent years, the need for micro-mobility, especially three-wheel vehicles, is increasing to address pollution and traffic congestion problems. With regard to the development of tilting vehicles, the precise tilt angle is important information in the tilting mechanism. Since the road environment affects the vehicle tilt angle, the road bank and hill angle have to be estimated to optimize the tilt control system. Furthermore, a new tilt mechanism is required due to the energy consumption of the previous active tilting mechanism. This paper introduces the road state observer. In this paper, the observer that combines a kinematic model with a dynamic model of a three wheel vehicle is proposed. The dynamic model has four states, including lateral velocity, yaw rate, tilt angle, and tilt angle ratio. Similarly, kinematic model has two states, including roll and pitch angles. It is assumed that the data set received from the six-dimensional inertial measurement unit including the vehicle acceleration and angular velocity of all axes is available. To verify the proposed algorithm, simulation verification using Carsim ADAMS and Matlab&Simulink is performed and a discussion of the result is provided. In addition, this paper proposes a semi-active tilt system.
Adaptive Engine Torque Compensation with Driveline Model
Authors: Park Jinrak , Choi Seibum , Oh Jiwon
Published: April 2018

Engine net torque is the total torque generated by the engine side, and includes the fuel combustion torque, the friction torque, and additionally the starter motor torque in case of hybrid vehicles. The engine net torque is utilized to control powertrain items such as the engine itself, the transmission clutch, also the engine clutch, and it must be accurate for the precise powertrain control. However, this net torque can vary with the engine operating conditions like the engine wear, the changes of the atmospheric pressure and the friction torque. Thus, this paper proposes the adaptive engine net torque compensator using driveline model which can cope with the net torque change according to engine operating conditions. The adaptive compensator was applied on the parallel hybrid vehicle and investigated via MATLAB Simcape Driveline simulation.
The design of a composite folding bike to improve the user experience of commuters
Authors: Vervisch Thomas , Christiaens Yannick , Detand Jan
Published: April 2018

Over the last years, the popularity of folding bikes has been increasing as a result of the rise of multi-modal transport. They are used by commuters as a complement to public transport. Despite the increasing popularity, the current market offer of folding bikes still represents quite some restrictions and downsides which decrease their usability. This paper shows a user-centred process of designing and prototyping a composite folding bike with the aim of improving the user experience of folding bike using commuters. By improving the usability and ease of use of folding bikes, their full potential can be unlocked. The design process led to a disruptive folding bike design with front and rear single-sided offset wheel mounting. The concept excels in its intuitive and quick folding mechanism, superior riding performance and comfort, adjustability and overall ease of use. In addition to the design process and prototyping of the folding bike, this extended abstract elaborates on the performed user tests and its results. These tests range from the impact of offset wheels to the intuitiveness of the folding mechanism and were performed in order to prove different aspects of the design. This research shows how rethinking and redesigning a bike concept (product) from scratch, using a user-centred design process and taking into account the three aspects — business, technology and people — can lead to a disruptive design that improves usability and the overall user experience of the stakeholders.
A Preliminary Study on the Priority of Business Evaluating Model for Design Office
Authors: Kim(a) Dae Young , Baek Nak Ku , Lee Dong Heon , Kim(b) Dae Young , Lim Hyoung Chul
Published: April 2018

Considering that we are at the initial phase of application Business Process Management model, a sequential application plan must be taken for each unit task. Adapting Business Process Management into the enterprise recourse of the construction industry across all business process could cause problems due to rapid change in corporate operation systems. We finally suggested the definition of Business Process Management model by analyzing each business unit so that we could propose and generalize value chain and business process architecture suitable for design office. Furthermore, by evaluating each business unit (which is included in the business process architecture), based on quantitative standards, we presented a sequential application plan for business process model.
The Study on Heuristic and Algorithmic Processing Creative Training on Product Design Education: Based on the Bags & Luggage design Course
Authors: Zhang Ziran , Yu Ying , Fan Shengxi , Tian Yujing
Published: April 2018

In the study, context-creativity of Teresa M. Amabile was used as The foundation to apply it in the bags & luggage design course. Moreover, the sectional creative training education mode of prior heuristic task and postpositional algorithmic task was proposed. 26 junior students in product design were used as the trial objects. The Consensual Technique for Creativity (CAT) was considered as the scoring standard of creative performance. In the end, the sectional theoretical framework of effective creative training in product design was finally proposed.