bluuebunny/crossref_metadata_2025 huggingface dataset:
Peculiarities of Professional Training of Educational Managers in Conditions of Transformation Processes
Authors: Prykhodkina Nataliia , Tymoshko Hanna , Sholokh Olena , Makhynia Tetiana , Koroliuk Svitlana , Genkal Svitlana
Published: June 2022

The article is devoted to the study of theoretical aspects of professional training of educational managers within the requirements of modern transformational society. In the conditions of the prevailing postmodernism new requirements to the manager of education as the specialist and as the person are allocated, according to what the emphasis on the influence of such processes as globalization, informatization, and innovative development on the preparation of modern experts in management is made. Changes in the educational paradigm indicate the need for a specialist with universal abilities, able to quickly adapt to new socio-economic and social changes and effectively perform their professional duties. The analysis of the newest tendencies in pedagogical education proves the growth of requirements to professionally significant qualities of the head of a modern educational institution. Based on a thorough analysis, the features of professional competence of education managers, their professionally important and personal qualities that determine their professional activity are determined. Among the main professionally significant qualities of an education manager are such as strategic thinking, readiness for self-development, ability to make operational decisions, special and general abilities, positive motivation of professional activity, cross-cultural competence, emotional intelligence and cognitive empathy, effective time management. It is established that the effectiveness of management activities of a modern education manager is determined by his ability to properly assess the business environment, set complex but achievable goals, organize staff for their implementation.
Development of Ukrainian Choral Art in Conditions of Postmodernism
Authors: Havrylenko Yuliia , Hrytsun Yuliia , Kondratenko Iryna , Sukhova Liubava
Published: June 2022

The article presents a research work in a context of highlighting the peculiarities of development of  Ukrainian choral art. The research describes the main theoretical and methodological approaches to defining the essence of choral art and postmodernism as a basis for the formation of a new worldview, a new thinking, which is a sign of a challenge of modernity. The basic context of formation of choral art is researched. The results of the research form the main historical trends in a development of choral art in the context of a basis of a human worldview and factors shaping an idea of worldview as a cultural manifestation of an era.

In the research the tendencies are identified in postmodern influence on the development of a culture, in particular choral art. Postmodernism is defined by a worldview that has become a challenge to the social development in the post-industrial era. In postmodern period appear art movements of surrealism, abstractionism, impressionism, symbolism and other cultural and art movements, which are reflected in an unrealistic way, indicating new trends in a new society.

We used analytical and research methods, a characteristic of music and game activities. Methods of a synthesis, an analysis and interpretation of choral art in a context of development of the Ukrainian culture were used for the research. The results of the research confirmed that in the conditions of postmodernism new tendencies of choral art are formed, which presents mental features in a context of information, a post-industrial society.
Enterpreneship Transformation in the Context of the Digitization of Business Processes
Authors: Lytvyn Lyubov , Hryhoruk Anatoliy , Verbivska Liudmyla , Poprotskyy Oleksandr , Medynska Tetiana , Pelekh Oksana
Published: June 2022

This article examines the transformation of enterprises activity in terms of digitalization of business processes. The rapid and global spread of information and communication technologies contributes to the development of the digital economy and causes changes in the economic environment, which leads to the transformation of business activities, methods of transactions and the level of connections between economic entities.

Globalization and digitalization of the economy transform the key characteristics and objectives of enterprises, the directions of their development and business management processes. Technological innovations create benefits that affect the economic system as a whole and its individual components. At the same time, the introduction of innovations is carried out in conditions of uncertainty and is associated with a high degree of risk that affects the economic security of enterprises.

In the new conditions of information economy development, the competitive struggle of enterprises is intensifying, the models of enterprise management are changing, and the level of digitalization of business processes is growing. The digital age is changing the approach to doing business.  The use of information technology such as marketing management systems, sales and service, telephony and messengers, document management and personnel management systems, accounting systems and other applications transform the activities of enterprises. In the process of enterprise modernization, information becomes a new factor of production, which gradually replaces other factors of production. Тechnology continues to be the largest sector in terms of market capitalization.

Effective implementation of innovations, digitalization of business processes allows companies to increase their productivity, achieve the required level of competitiveness and take a stable position in the markets.
Contemporary Geoinformation Technologies in Postmodern Education of Geographers, Hydrometeorologists, Land Surveyors
Authors: Yushchenko Yuriy , Pasichnyk Mykola , Darchuk Kostiantyn , Kostashchuk Ivan , Zakrevskyi Oleksandr
Published: June 2022

There is a problem of incision of rivers. To solve it, it is necessary to obtain and analyze objective information about the processes of incision and related processes of changes in morphology, structure, functioning of the flow-channel system, the young river landscape. The next step in solving the problem is an objective analysis of possible factors of incision. The main factor in the studied objects is the extraction of river alluvium for many decades. It is also important to identify and study the consequences and extent of changes in the young river landscape, to assess its condition. We propose a method of analysis of processes and factors of incision that can be applied to other rivers, it can also be supplemented and developed. It allows to put in perspective the situation and justify the necessary solutions in the process of planning integrated management of the young river landscape as an important component of the river basin system. Significantly anthropogenically altered sections of rivers, their channels and floodplains may occur as a result of incision. They need special public attention to restore the environmental properties of capacity building. This is an integral part of the culture of interaction between society and rivers, which primarily includes objective quality monitoring, availability and quality of all necessary information (its systematicity, system analysis) as a basis for effective decision-making. An important conclusion is the feasibility of monitoring changes in the vertical position of channels and floodplains, as well as changes in alluvial deposits as part of hydromorphological monitoring in general. In particular, conducting GPS surveillance.
Morvan syndrome presenting with agrypnia excitata in post-thymectomy myasthenia gravis: a case report
Authors: Oh Seong-il , Kang Mi-Ri , Ji Ki-Hwan
Published: June 2022

Background: Morvan syndrome is characterized by neuromyotonia, dysautonomia, and various neuropsychiatric symptoms, as well as sleep disturbances, although these are less common than neuromuscular symptoms. Herein, we report a case of Morvan syndrome with peculiar sleep disturbances, documented via polysomnography. Case Report: We present herein the case of a 67-year-old man who developed agitation and severe insomnia after undergoing a thymectomy for the treatment of myasthenia gravis, which was subsequently diagnosed as agrypnia excitata due to Morvan syndrome, based on 24-hour polysomnography. Conclusion: We presented the 24-hour polysomnographic findings of a case of agrypnia excitata in Morvan syndrome. An extended polysomnography, however, might be helpful in analyzing sleep disturbances in Morvan syndrome.
Newcomer Wellbeing and Placemaking in Southeast England
Authors:   University of Sussex, Soye Emma , Watters Charles
Published: June 2022

How do refugees and asylum seekers experience wellbeing and placemaking in urban contexts? The Displacement, Placemaking and Wellbeing in the City (DWELL) project explored this question through interviews with people working for non-governmental and community organisations in southeast England. It found that the current asylum system negatively impacts wellbeing and placemaking for asylum seekers, and that access to urban spaces is key to building community connections. Non-governmental organisations and faith groups play an important role in sustaining a sense of wellbeing and place for refugees and asylum seekers.
Co-Designing Urban Play Spaces to Improve Migrant Children’s Wellbeing
Authors:   Dr B.R. Ambedkar University Delhi, Dar Anandini , Chopra Divya
Published: June 2022

Between 2001 and 2011, India’s urban population increased from almost 28 per cent to just over 31 per cent. Almost 139 million people migrated to cities (mainly Delhi and Mumbai), often bringing their children with them. Most live in poverty in informal settlements that lack basic infrastructure and services. Their children are often out of school and have no safe spaces to play. The United Nations Convention on the Rights of the Child (UNCRC), ratified by India in 1989, recognises children’s right to play as fundamental to their social, emotional, and physical wellbeing. Urban planners need to involve children in co-designing better neighbourhoods that accommodate children’s right to play.
“It's Frustrating, but…”: Brazilian and Indonesian Teachers’ Resilience to Assist Deaf Students’ Online Language Learning
Authors: De Moraes Antonio Henrique Coutelo , Indah Rohmani Nur
Published: June 2022

Due to the recent increase in studies on emotions in Applied Linguistics and, especially now, in pandemic times, it opens more discussion to relate teachers' emotions with several other aspects including resilience. Therefore, this research aims to analyze language teachers’ experience in teaching deaf students in Recife, Brazil, and Malang, Indonesia. The methodology applied was qualitative. This study involved teachers in Recife, Brazil, and Malang, Indonesia. The teachers selected to be interviewed in this study were those who had experience teaching deaf students for at least five years and those who, during the pandemic times taught online. Two teachers were taken from each city. Findings point out, among other things, that decreasing the number of students per class and having parents involved in the process may help improve students' learning and teachers' experience and resilience. Based on the data on the implementation of language learning and the teachers' perception of the benefit, the constraints, and strategies in online language learning, resilience is triggered by the professional, personal, institutional, and community challenges.
West Coastal Toponyms of Sumatra Island: A Corpus Linguistics Study
Authors: Triana Hetti Waluati , Kustati Martin , Nelmawarni Nelmawarni , Reflinaldi Reflinaldi
Published: June 2022

Several pieces of research on the toponym of place names in Indonesia have been carried out but focus on place names on the island of Java. The limited documentation of place names makes the study of toponymy in Sumatra a must. This article aims to map the thematization of place naming on the West Coast of Sumatra Island. The research was conducted in a qualitative descriptive manner with a corpus linguistic approach. Data was collected by means of documentation, interviews, and focus group discussions. Data were analyzed by following work procedures by Miles and Huberman (2013), involving data condensation, data display, verification drawing, and Sudaryat's toponymy categorization (2009). The results showed that the toponym of place names on the West Coast of Sumatra Island reflects the relationship between humans and their natural environment. This relationship is manifested through the thematization of place names, namely: embodiment, social, and culture. The embodiment aspect includes the sub-themes of water background, topographical background, and natural environment background. The social aspects include the sub-themes of residential background, economic activity background, and building background. The cultural aspects include sub-themes of myths, folklore, and legends passed down through oral traditions.
Imaginando el futuro: ejes centrales para un modelo de Responsabilidad Social Universitaria
Authors: González Rodríguez Guillermo Isaac
Published: June 2022

La misión universitaria es un tema de debate que es considerado desde hace algunas décadas, como algo que se debe reformarse con la intención de estar acorde a las necesidades de los distintos contextos. El presente trabajo hace un abordaje al papel que asumen las universidades respecto a su misión y sus funciones sustantivas en aras de asimilar las problemáticas sociales y responder con ello a la Responsabilidad Social Universitaria (RSU). Se tiene el objetivo de describir los principales elementos que se encuentran alrededor de un modelo de RSU de cara a enfrentar la etapa posmoderna. Para ello, se toma como base la agenda 2030 de la Organización de las Naciones Unidas (ONU) como eje central, así como las posturas de la gestión social del conocimiento y la RSU para el análisis. Como resultado, se ofrecen una serie de elementos que pueden servir como base para la formulación de un modelo de aprovechamiento social del conocimiento mediante el desarrollo de proyectos desde la universidad que sean aplicables al entorno social y con los cuales se fomente en la comunidad académica y estudiantil, una conciencia sobre los problemas que deben atenderse como prioridad en los distintos ámbitos sociales.
Palabras clave: Misión; Responsabilidad Social Universitaria; Objetivos de desarrollo sostenible; Gestión social del conocimiento; Universidad.
Elevated Plasma Soluble ST2 Levels are Associated With Neuronal Injury and Neurocognitive Impairment in Children With Cerebral Malaria
Authors: Fernander Elizabeth , Adogamhe Pontian , Datta Dibyadyuti , Bond Caitlin , Zhao Yi , Bangirana Paul , Conroy Andrea L. , Opoka Robert O. , John Chandy
Published: June 2022

Background: Murine experimental cerebral malaria studies suggest both protective and deleterious central nervous system effects from alterations in the interleukin-33 (IL-33)/ST2 pathway. 
Methods: We assessed whether soluble ST2 (sST2) was associated with neuronal injury or cognitive impairment in a cohort of Ugandan children with cerebral malaria (CM, n=224) or severe malarial anemia (SMA, n=193). 
Results: Plasma concentrations of sST2 were higher in children with CM than in children with SMA or in asymptomatic community children. Cerebrospinal fluid (CSF) sST2 levels were elevated in children with CM compared with North American children. Elevated plasma and CSF ST2 levels in children with CM correlated with increased endothelial activation and increased plasma and CSF levels of tau, a marker of neuronal injury. In children with CM who were ≥5 years of age at the time of their malaria episode, but not in children <5 years of age, elevated risk factor-adjusted plasma levels of sST2 were associated with worse scores for overall cognitive ability and attention over a 2-year follow-up. 
Conclusions: The study findings suggest that sST2 may contribute to neuronal injury and long-term neurocognitive impairment in older children with CM.
Estimating the performance of a material in its service space via Bayesian active learning: a case study of the damping capacity of Mg alloys
Authors: Shi Bofeng , Zhou Yumei , Fang Daqing , Tian Yuan , Ding Xiangdong , Sun Jun , Lookman Turab , Xue Dezhen
Published: June 2022

In addition to being determined by its chemical composition and processing conditions, the performance of a material is also affected by the variables of its service space, including temperature, pressure, and frequency. A rapid means to estimate the performance of a material in its service space is urgently required to accelerate the screening of materials with targeted performance. In the present study, a materials informatics approach is proposed to rapidly predict performance within a service space based on existing data. We utilize an active learning loop, which employs an ensemble machine learning method to predict the performance, followed by a Bayesian experimental design to minimize the number of experiments for refinement and validation. This approach is demonstrated by predicting the damping properties of a ZE62 magnesium alloy in a service space defined by frequency, strain amplitude, and temperature based on the available data for other magnesium alloys. Several utility functions that recommend a particular experiment to refine the estimates of the service space are used and compared. In particular, the standard deviation is found to reduce the prediction error most efficiently. After augmenting the database with nine new experimental measurements, the uncertainties associated with the predicted damping capacities are largely reduced. Our method allows us to forecast the properties in the service space of a given material by rapid refinement of the predictions via experiment measurements.
IMPACT OF THE SMART GRID SYSTEM ON THE NATIONAL ENERGY NETWORK
Authors: Lobodzinskiy V. , Buryk M. , Petruchenko O. , Illina О.
Published: June 2022

Modern power system technologies offer the integration of renewable energy in electricity grids, intelligent metering, bidirectional communication between power generation units and the central control system for energy production and consumption, prevention of power outages, sustainable and safe energy sources, and energy security. Moreover, the modern energy system requires control, measurement and cybersecurity of energy processes at every point of the grid.

The infrastructure of the national networks of many countries is very old and includes classic technologies of production, transmission and distribution of electricity. In addition, the controllability and managebility of these systems are also unsatisfactory. On the other hand, Smart Grid technologies include sophisticated tools to monitor and control the power system in both directions from power plants to end users or vice versa so that vulnerabilities can be identified in advance and the necessary measures taken. In addition, the smart grid system offers monitoring and management of electricity from production to the end user, as well as provides smart accounting, integration of renewable energy into the grid. Morover, the efficient use of energy sources with minimal losses and minimal illegal use is also addressed in smart grid technology. This article highlights the impact of smart grid technologies on national power grids and offers some useful suggestions for transforming their classic power grid system into a Smart Grid grid system.

Transforming the classic network into an intelligent one fills its own business areas and provides increased efficiency, loss reduction, flexible price for consumers, safe and stable electricity, as well as reliable and digital infrastructure.

As a result, building a Smart Grid is a complex task, starting with a detailed quantification of system requirements, determining the actual goals and the levels of operation needed to achieve them. This research will be an effective and efficient tool for researchers, engineers, transmitter operators and distributors to transform the classical national energy system into an intelligent energy system.
VineyardFACE: Investigation of a moderate (+20 %) increase of ambient CO2 concentration on berry ripening dynamics and fruit composition of Cabernet-Sauvignon
Authors: Kahn Cécile , Tittmann Susanne , Hilbert Ghislaine , Renaud Christel , Gomès Eric , Stoll Manfred
Published: June 2022

Climate change and rising atmospheric carbon dioxide concentration are a concern for agriculture, including viticulture. Studies on elevated carbon dioxide have already been conducted on grapevines, mainly taking place in greenhouses using potted plants or using field-grown vines under instant and higher CO2 enrichment, i.e., > 650 ppm. The VineyardFACE, located at Hochschule Geisenheim University, is an open field Free Air CO2 Enrichment (FACE) experimental set-up designed to study the effects of elevated carbon dioxide using adapted, field-grown vines (Vitis vinifera L. cv. Cabernet-Sauvignon). As the carbon dioxide fumigation started in 2014, the long-term effects of elevated carbon dioxide treatment can be investigated on berry ripening parameters and fruit metabolic composition.The present study investigates the effect on fruit composition under a moderate increase (+20 %; eCO2) of carbon dioxide concentration, as predicted for 2050 on Cabernet-Sauvignon. Berry growth, ripening dynamics and composition were determined and primary (sugars, organic acids, amino acids) and secondary metabolites (anthocyanins) were analysed. Compared to previous results of the early adaptive phase of the vines (Wohlfahrt et al., 2020), our results show little effects of eCO2 treatment on primary metabolites composition in berries. However, total anthocyanins concentration in berry skin was lower for eCO2 treatment in the hot and dry season of 2020, although the ratio between anthocyanins derivatives did not differ.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 18.06.2022 г. по 24.06.2022 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: June 2022

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19, за неделю с 18.06.2022 г. по 24.06.2022 г.
Peroneus Longus and Peroneus Brevis
Authors: Koutsogiannis Petros , Frane Nicholas , Aliyev Teymur , Regala Peter , Tarazi John M. , Bitterman Adam D.
Published: June 2022

» Peroneus longus (PL) and peroneus brevis (PB) pathologies involve a variety of etiologies and degrees of dysfunction, which complicates their diagnoses.

» Patient presentation includes a spectrum of disease; however, despite advanced imaging, a misunderstanding of the pathology and diagnostic algorithms has contributed to continued misdiagnoses.

» This article summarizes the anatomy and the pathophysiology of the PL and the PB; it also provides updated treatment options and their associated outcomes in order to illuminate an often-misunderstood topic.
The Role of Stability and Alignment in Improving Patient Outcomes After Total Knee Arthroplasty
Authors: Vajapey Sravya P. , Fitz Wolfgang , Iorio Richard
Published: June 2022

» Total knee arthroplasty (TKA) is an effective treatment option for many patients, but a small group of patients are dissatisfied following TKA.

» Alignment, in combination with balance, stability, and knee kinematics, is an important modifiable surgical factor that can affect patient outcomes.

» Driven by the subset of dissatisfied patients after TKA, new techniques have evolved in the search for a more anatomic reconstruction of individual knee morphology and a more accurate approximation of the individual lower-extremity alignment.

» There is a need to optimize 3 aspects of TKA to improve patient outcomes—mechanical tooling processes, implants that resurface the epiphysis, and techniques that respect the variable anatomy of patients.
Construction of a Predictive Model of Respiratory Endoscopic Intervention in Children with Lobar Pneumonia Caused by Mycoplasma Pneumoniae Infection
Authors: Zhang Jiahui , Ma Yu , Sun Zhichao , Wang Ting , Yan Yongdong , Huang Li , Chen Zhengrong
Published: June 2022

Objectives: This study aimed to analyze the clinical features of children with lobar pneumonia caused by Mycoplasma pneumoniae (MP) infection, to provide a prognostic evaluation of interventional bronchoscopy, and to explore the independent risk factors for bronchoscopic intervention in children with lobar pneumonia caused by MP infection. We also aimed to construct an early-warning model of bronchoscopic intervention, so as to provide an objective evaluation tool for clinicians.Methods: We collected the clinical data from 533 children with lobar pneumonia caused by MP infection. The patients were divided into three groups according to the interventional indications for bronchoscopy and whether they were treated with bronchoscopic intervention, and the clinical features and prognosis of the three groups were compared. Binary logistic regression analysis was performed on the indicators with a significance value of P < 0.05, which we retrieved from the comparative analysis between the first two groups, in order to uncover the independent risk factors and regression equations concerning bronchoscopic intervention. The regression coefficient (β) of our regression model was then used to score related values in the model so as to construct a predictive scoring model of bronchoscopic intervention for the treatment of children with lobar pneumonia caused by MP infection.Results: Children with lobar pneumonia caused by MP infection who demonstrated absolute indications for bronchoscopy exhibited more severe clinical manifestations, and children without absolute indications for bronchoscopy achieved a better prognosis even without bronchoscopic intervention. To establish our early-warning model of bronchoscopic intervention for children with lobar pneumonia caused by MP infection, we utilized the following indices: a C-reactive protein (CRP) ≥ 20.94 mg/L (β1 = 2.253) received 3 points; a fever duration before bronchoscopy ≥ 6.5 d (β2 = 1.424), lactate dehydrogenase (LDH) ≥ 461.5 U/L (β3 = 1.246), or fever (β4 = 1.223), each received 2 points; and if complicated by pleural effusion (β5 = 0.841), 1 point, for a total score of 10 points.Conclusions: When the score for the children with lobar pneumonia caused by MP infection was ≥6, the possibility of bronchoscopic intervention for treatment was higher than 80%. The higher the score, the greater the possibility of bronchoscopic intervention.
A Novel Starch Digesting Halo-Acid-Alkali-Tolerant and Surfactant Stable Amylase from Newly Isolated Halophilic Bacterium Bacillus Siamensis Sp. F2: Application in Waste Valorization to Ethanol Fermentation
Authors: Rathod Baliram Gurunath , Pandala Srinija , Poosarla Venkata Giridhar
Published: June 2022

The extracellular amylase production level by the moderate halophile Bacillus siamensis sp. F2 was optimized, and the enzyme was biochemically characterized. The culture parameters for NaCl, carbon, nitrogen, pH, and temperature were optimized for high titers of amylase production. Growing Bacillus siamensis sp. F2 cultures in Great Salt Lake-2 medium with additions of (in g/l) NaCl (100), starch (30), yeast extract (2), KNO3 (2), and MgSO4 (1) at pH 8, 30°C resulted in the maximum amylase production (4.2 U/ml). The amylase was active across a wide range of salinities (0 to 30% NaCl), pH (5.0–10.0), and temperatures (20–70oC), and showed good stability with surfactants (SDS and Triton X-100); hence identified as halo-acid-alkali-tolerant and surfactant stable. Temperature, pH, and salinity were optimal for amylase activity at 50°C, pH 7, and 5% NaCl, respectively. It also generates amylase utilizing agricultural wastes like sugarcane bagasse, wheat bran, and rice husk. Based on the performance of Bacillus siamensis sp. F2 using sugarcane bagasse and synthesizing amylase, the current study attempted to produce bioethanol by co-culturing with baker's yeast, which yielded 157 g/L of bioethanol. This novel amylase may have many potential applications in industrial waste-valorization and biorefinery sectors.
Personal and work-oriented characteristics distinguishing older nurses’ partial or complete actual retirement behavior over three years
Authors: Rodwell John
Published: June 2022

The authors have requested that this preprint be removed from Research Square.
WITHDRAWN: Alpha-fetoprotein Promotes Hepatocellular Carcinoma Progression by Negatively Regulating Hippo Signaling Pathway Running title: AFP Regulate the Hippo Signaling Pathway
Authors: Leng Guangxian , Wu Fahong , Gong Hongxia , Liu Guiyuan , Wei Hangzhi , Guo Liuqing , Ma Hanwei , Kong Yin , Wang Mancai , Zhang Youcheng
Published: June 2022

Background: Alpha-fetoprotein (AFP) is a specific tumor marker for hepatocellular carcinoma (HCC) and promotes tumor cell proliferation in HCC, but the mechanism is not completely clear. This research aimed to supplement the mechanism of AFP in HCC. Methods: Lentivirus transfected HCC cells for AFP knockdown and overexpression, CCK-8, clone formation, scratch assay, and 3D multicellular tumor spheroids（MCTS） formation assay verified the positive regulation of AFP on HCC. Co-immunoprecipitation, liquid chromatography-mass spectrometry (LC-MS/ MS), and bioinformatics techniques were used to identify proteins interacting with AFP and related pathways in HCC cells, and western blot, real-time quantitative PCR(RT-qPCR), and immunofluorescence were used to detect the expression changes of proteins associated with AFP pathways. The effect of AFP on the HCC cell cycle was detected by flow cytometry. Results: AFP promotes the proliferation, migration, and the formation of MCTS of HCC cells. In HCC, AFP interacts with large tumor suppressor 2 (LATS2) and negatively regulates Hippo signaling pathway. AFP inhibits the phosphorylation of LATS2, which in turn inhibits the phosphorylation of yes associated protein (YAP). In addition, AFP was positively correlated with the expression of CyclinD1. Conclusion: AFP negatively regulates Hippo signaling pathway through the LATS2/YAP axis and promotes the proliferation, migration, and formation of MCTS of HCC cells.
Whole-Transcriptome RNA Sequencing Reveals the Molecular Responses and C eRNA Regulatory Network under Simulated Long-term Spaceflight Composite Stress in Hippocampus
Authors: Yin Yishu , Liu Junlian , Xu Chong , Zeng Deyong , Wu Xiaorui , Zhu Yuanbing , Fan Quanchun , Zhao Shuang , Wang Jiaping , Liu Yu , Jiao Lei , Li Yongzhi
Published: June 2022

To systematically evaluate the affect of simulated long-term spaceflight composite stress (LSCS) in hippocampus and to gain more insights into the transcriptomic landscape and molecular mechanism, we performed whole-transcriptome sequencing based on the control group (Ctrl) and the simulated long-term spaceflight composite stress group (LSCS) from six hippocampus of rats. Subsequently, differential expression analysis was performed on the Ctrl and LSCS groups, followed by enrichment analysis and functional interaction prediction analysis to investigate gene-regulatory circuits in LSCS. In addition, competitive endogenous RNA (ceRNA) network was constructed to gain insights into genetic interaction. The result showed that 276 differentially expressed messenger RNAs (DEmRNAs), 139 differentially expressed long non-coding RNAs (DElncRNAs), 103 differentially expressed circular RNAs (DEcircRNAs), and 52 differentially expressed microRNAs (DEmiRNAs) were found in LSCS samples compared with the controls, which were then subjected to enrichment analysis of Gene Ontology (GO) term and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways to find potential functions. PI3K-Akt signaling pathway and MAPK signaling pathway may play fundamental roles in the pathogenesis of LSCS. A ceRNA network was constructed with the predicted 340 DE pairs, which revealed the interaction roles of 220 DEmiRNA-DEmRNA pairs, 76 DEmiRNA-DElncRNA pairs, and 44 DEmiRNA-DEcircRNA pairs. Further, Thrombospondins2 was found to be a key target among those ceRNAs. Overall, we conducted for the first time a full transcriptomic analysis of the response of hippocampus to the LSCS that involved a potential ceRNA network, thus providing a basis to study the underlying mechanism of the LSCS.
Using End-to-End imbalanced Temporal Deep Gaussian Process (iTDGP) to Predict Acute Ischemic Stroke Lesions
Authors: Soltanpour Mohsen , Yousefnezhad Muhammad , Greiner Russ , Boulanger Pierre , Buck Brian
Published: June 2022

As one of the leading causes of mortality and disability worldwide, Acute Ischemic Stroke (AIS) occurs when the blood supply to the brain is suddenly interrupted because of a blocked artery. Within seconds of AIS onset, the brain cells surrounding the blocked artery die. The automated and precise prediction of AIS lesions plays a vital role in the treatment planning and prevention of further injuries. Unfortunately, the current standard AIS assessment method, which thresholds the 3D measurement maps extracted from Computed Tomography Perfusion (CTP) images, is not accurate enough. Due to this fact, in this article, we propose the imbalanced Temporal Deep Gaussian Process (iTDGP), a probabilistic model that can improve AIS lesions prediction by using baseline CTP time series. Our proposed model can effectively extract temporal information from the CTP time series and map it to the class labels of the brain's voxels. In addition, by using batch training and voxel-level analysis iTDGP can learn from a few patients and it is robust against imbalanced classes. Moreover, our model incorporates a post-processor capable of improving prediction accuracy using spatial information. Our comprehensive experiments, on the ISLES 2018 and the University of Alberta Hospital (UAH) datasets (including 63 and 100 patients respectively), show that iTDGP performs better than state-of-the-art AIS lesion predictors, obtaining the (cross-validation) Dice score of 71.42% and 65.37% with a significant p<0.05, respectively.
Readability Assessment of Online Men's Health Education Materials from the Sexual Medicine Society of North America, Urology Care Foundation, and European Association of Urology.
Authors: Callegari Michael , Pominville Raymond , Zhou Christopher , Piyevsky Brandon , Jesse Erin , Prunty Megan , Loeb Aram , Thirumavalavan Nannan , Ghayda Ramy Abou
Published: June 2022

Introduction: The use of online health information by patients has gained considerable attention during the last decade. The National Institute of Health (NIH) and American Medical Association (AMA) advocate the dissemination of accessible and readable resources. We aimed to evaluate the readability of online patient resources from the Sexual Medicine Society of North America (SMSNA) website.Methods: Content published under the web-section “SMSNA: For Patients - conditions and topics'' portal (n=16) were reviewed. Identical topics published online via Urology Care Foundation (ie AUA; n=8) and the European Association of Urology (ie EAU; n=8) were also reviewed. Readability and estimated educational level required for understanding was assessed using validated readability and English language assessment tools including the Flesh Reading Ease score, Flesch Kincade, Gunning Fog, Simple Measure of Gobbledygook (SMOG), Coleman-Liau and Automated Readability index.Results: SMSNA online patient education materials (PEM), on average, are written at a college sophomore reading level (14th grade). This is 6.5 and 8 grade levels higher than the average U.S. adult and recommended reading levels for PEM, respectively. Comparable AUA and EAU resources were an average of 10th (p<0.05) and 12th (p=0.854) grade reading levels, respectively.Conclusion: Men’s sexual health PEM’s published online are written at an advanced reading level, most notably the SMSNA compared to equivalent professional sources. This could pose a barrier to patient understanding and impact patients’ engagement and health decision-making. One proposed mitigatory strategy is for PEM to provide improved readability, and appropriate user-friendly language to facilitate easier and inclusive understanding, outreach and educational support.
The practice of COVID-19 prevention strategy post vaccination among health professionals in Felege Hiwot Referral Hospital, Northwest Ethiopia
Authors: Engdaw Garedew Tadege , Worede Eshetu Abera , Destaw Bikes
Published: June 2022

Background
Corona Virus Disease is an acute respiratory illness first discovered and identified in China. Countries are taking various precautions to prevent COVID-19 in accordance with WHO guidelines.
Objective
The objective of this study is to assess the practice of the COVID-19 prevention strategy post vaccination and associated factors among health professionals in Felege Hiwot Referral Hospital, Bahir Dar, Northwest Ethiopia, in 2021.
Methods
An institutional-based cross-sectional study was carried out at Felege Hiwot Referral Hospital, Bahir Dar Ethiopia.
Results
In this study, 68.7% (95% CI: (63.7, 73.8)) of health care professionals had good practice of the COVID-19 prevention strategy post vaccination. Sex, 1.76% (95% CI: (1.08, 2.89), Marital status (Married) 1.75% (95% CI: (1.09, 2.93)), and good attitude towards vaccination 3.42% (95% CI: (2.13, 5.48)) were significantly associated with the practices of health care professionals post vaccination.
Conclusions
The practices of COVID-19 preventive strategies post vaccination was good among healthcare professionals.
Dielectric Characterization and Statistical Analysis of Ex-Vivo Burnt Human Skin Samples For Microwave Sensor Development
Authors: Rangaiah PRAMOD K B , Kouki Mokhtar , Dhouibi Yasmina , Huss Fredrik , Mandal Bappaditya , Augustine Bobins , Perez Mauricio D , Augustine Robin
Published: June 2022

Precise data acquisition, characterization, and finding the relationship between permittivity variations of human skin with degree of burns is critically important because It further helps in the development of excellent sensor devices for diagnostics and treatment of patients suffering from burns and scalds. This work is also a part of the European “Senseburn” project that focuses to develop a non-invasive diagnostic tool for the assessment of human burns based on its degree and depth in the clinical setup. In this work, several Ex-vivo burnt samples were collected from the Uppsala University Hospital (Akademiska sjukhuset, Sweden), and out of that, eight samples with different burn degrees and of various human body parts were selected for the analysis. The dielectric characterization of the categorized samples was done by using an open-end co-axial probe kit. The measurement was made systematically and clinician feedback forms were maintained throughout the process. The measurement data followed the FASTCLUS procedure which was analyzed initially using density plot, Convergence, and cubic clustering criteria respectively. The dielectric characterization was made from 500 MHz to 10 GHz with 1001 points and from the previous sensor designs, the results were found to be excellent between 500 MHz to 5 GHz. For the statistical analysis, 11 frequency points were considered for 8 samples. The results of the basic statistical analysis using the FASTCLUS procedure resulted in 88 data sets. Later, data sets were analyzed based on the cluster-wise of all samples and sample-wise clusters. Every sample was made with two clusters i.e, cluster 1 which consisted of healthy sectors, and cluster 2 which consisted of burnt sectors. Furthermore, we found that the permittivity differences of clusters are proportional to the degree of the burns. This is pivotal information and It helps to improve the functioning of the diagnostic microwave sensors by designing them according to the permittivity variations. For this purpose, an extensive campaign of around 1000 measurements across a band of 1–30 GHz was done and it leads to the conclusion that each skin region of interest (ROI) provides unique dielectric properties.
Association between plasma-free hemoglobin levels, lactate dehydrogenase and hemolysis-index in patients with and without mechanical circuit support - a retrospective data analysis
Authors: Zapletal Bernhard , Zimpfer Daniel , Schloeglhofer Thomas , Fritzer-Szekeres Monika , Szekeres Thomas , Bernardi Martin Herrmann , Kainz Michael , Neugebauer Thomas , Tschernko Edda Maria
Published: June 2022

Purpose
Hemolysis is a frequent problem in patients with mechanical circulatory support (MCS) that can indicate device malfunctions or pump thrombosis. In this retrospective cohort study, we assessed whether hemolysis index (HI) can replace plasma free hemoglobin (fHb) and lactate dehydrogenase (LDH) to guide anticoagulation and performed a cost analysis to combine medical with economical efficacy.
Methods
We correlated simultaneously obtained HI, fHb, LDH measures of venous blood samples in a cohort of 96 ICU patients. 429 datasets (40.7%) were collected from patients with and 556 datasets (52.8%) without extracorporeal life support (ECLS). 68 (6.5%) from a cohort of 51 outpatients on LVAD support. A cost analysis of all three hemolysis monitoring options was performed.
Results
Correlation of HI and fHb values was highly significant (r = 0.968, p < 0.01) overall and equally significant (r = 0.949, p < 0.01) in samples with clinically significant hemolysis (HI ≥ 20). Correlation of fHb and LDH was low (r = 0.192, p < 0.01) in all patients. Estimated cost per ICU patient on ECLS was 0 USD if HI, 4.347.25 (794.21-5350.46) USD if fHb, 383.29 (70.02-471.74) USD if serial measurements of LDH were used for hemolysis monitoring.
Conclusions
HI represents a cost-efficient, accurate and easily obtainable alternative to fHb measurements for clinicians treating patients with and without MCS, whereas LDH is significantly less specific. Further clinical studies on major cohorts of short and long-term MCS patients are needed to assess the optimal HI target with minimal thromboembolic as well as bleeding events.
Topological pressure on subsets for fixed-point free flows
Authors: Ji Yong , Wang Yunping
Published: June 2022

In this paper we introduce Pesin-Pitskel’s pressure for fixed-point free flows. By proving an result about ergodic approximation for flow, we establish two variational principles. A Billingsley type theorem for pressure is also given.
Effects of Nitrogen and Phosphorus on the Regulation of Germination, Seedling Growth and the Yield Traits of Perennial Cool-Season Forage Grasses
Authors: Chen Zhao , Niu Junpeng , Guo Zhipeng , Cao Xinlong , Yan Xuebing , Wang Quanzhen
Published: June 2022

Purpose Crop production in saline-alkali soils is often challenged by excessive fertilization, that can increase carbon equivalent emissions, and also by inadequate soil quality, thereby threatening sustainability. Previous researches on fertilization management focused on the short-term effects of single application of nitrogen (N) and phosphorus (P). Little is known about the long-standing effects that combined N and P fertilizers on seedling growth and crop yields. Thus, specific knowledge regarding the interactions between N and P fertilizers management practices targeting improved system sustainability on crop yield and quality.Methods Using combinations of 18 levels of N fertilizer and 16 levels of P fertilizer, we conducted multi-factorial, orthogonally-designed field experiments with large sample sizes for three years to determine the optimal ratio of N and P for germination, seed yield, seedling growth and yield components of six grasses. Results We calculated the mode of the physiological traits and used the thickest value as the optimum, and found a significantly antagonistic interaction between N and P for seedling growth traits, seed components and seed yields when the N: P ratio was between 2 and 3, with the optimal N: P ratio being 2.86:1. And the plants treated with high N and low P had higher values for physiological traits, seed components and seed yields, and strongly promoted vegetative/reproductive growth of seedlings. Conclusion These results can be applied to develop breeding strategies and quality detection in saline-alkali environments that contain soil with low availability of N and P.
Drag Reducing Nose Fairings for Existing Freight Train Locomotive
Authors: Stucki Chad L. , Maynes Daniel
Published: June 2022

At cruising speed, the largest contributing factor to train fuel consumption is aerodynamic drag, and the leading locomotive experiences much more drag than any other car in the train. This work reports on the drag reduction that can be realized by the use of add-on nose fairings that are deployed on leading locomotives in a train set. Two types of fairing shapes were considered and all fairing walls are flat. It is anticipated that the fairing shapes would result from the deployment of easily stowed panels in an origami inspired manner. One of the fairing shapes has the appearance of a wedge and the other fairing is also wedge shaped, but with flow directing side wall features. For each general fairing shape, the important dimensions were parametrically varied in a systematic manner to identify the dimensions that yield maximum drag reduction. For the first shape, 45 different scenarios were considered; for the second shape, 15 were considered. A steady commercial computational fluid dynamic solver was employed to solve the flow field and locomotive drag for each of the scenarios. The best performing wedge-shaped fairing reduced the leading locomotive drag by nominally 14% and the best performing fairing shape with the side walls reduced the drag by 17%.
Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway
Authors: Meng Fan , Zhang Xiaokang , Wang Yanting , Lin Jie , Tang Yulin , Zhang Guisheng , Qiu Binqiang , Zeng Xingdu , Liu Weiyou , He Xin
Published: June 2022

Background: The morbidity and mortality of esophageal squamous cell carcinoma (ESCC) remain high globally. Circular RNAs (circRNAs) play an important role in tumor progression. We discovered a novel aberrantly expressed circRNA (hsa_circ_0021727) in ESCC patients. However, the mechanism of hsa_circ_0021727 in tumors is still not elucidated. The purpose of this article is to investigate the biological role of hsa_circ_0021727 and its role in ESCC progression.Methods: Microarray analysis was used to screen diferentially expressed novel circRNAs.qRT-PCR,RNA-ISH and FISH were used to analyze the expression and localization of hsa_circ_0021727.MTT, colony formation, EdU, transwell assay, three-dimensional (3D) spheroid invasion assays and wound healing assays were used to describe biological effects on ESCC cells.Xenograft experiment and tail vein injection experiment were used to analyze tumor growth and metastasis in vivo.RNA-sequencing was used to identify hsa_circ_0021727 downstream targets.Western blot was used to detect the downstream protein expression of hsa_circ_0021727.RNA pulldown and dual luciferase experiments were used to evaluate the interaction of hsa_circ_0021727, miR-23b-5p and TAB1.Results: We screened a novel circRNA (hsa_circ_0021727) whose expression was upregulated in ESCC patients.ESCC patients with high expression of hsa_circ_0021727 had shorter survival time.Hsa_circ_0021727 promoted the proliferation, invasion and migration of ESCC cells. However, miR-23b-5p inhibited this ability of hsa_circ_0021727. MiR-23b-5p acts by targeting TAB1. In conclusion, hsa_circ_0021727 promoted ESCC progression by upregulating the expression of TAK1-binding protein 1(TAB1) via "sponge adsorption" of miR-23b-5p. In addition, in vivo experiments also confirmed that hsa_circ_0021727 can promote the proliferation, invasion and migration of ESCC cells.Conclusions：Hsa_circ_0021727 (circ_CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway.These findings may provide potential targets for the treatment of ESCC.