bluuebunny/crossref_metadata_2025 huggingface dataset:
Fighting fear: the buffering of well-being-HRM on the effects of nurses’ fear of COVID-19 on job stress and patient care
Authors: Bartram Timothy , Tham Tse Leng , Meacham Hannah , Halvorsen Beni , Pariona-Cabrera Patricia , Cavanagh Jillian , Holland Peter , Afshari Leila
Published: September 2024

Purpose

Pre-pandemic research demonstrated the challenges of the nursing workforce and the provision of quality of patient care. Such challenges have been significantly intensified during the COVID-19 pandemic, not least in the workplace and fear of staff catching and transmitting COVID-19. We draw on conservation of resources (COR) theory to examine the impact of the fear of COVID-19 on nurses and the role of well-being-HRM (WBHRM) in negating the fear of COVID-19 and its impact on job stress and perceived quality of patient care.

Design/methodology/approach

We collected data from 260 nurses (treating COVID-19 patients) employed in US hospitals across two-waves. Data were analyzed using mediated regression and moderated mediation.

Findings

The results indicated that when nurses report higher levels of fear of COVID-19, this translates into higher levels of nursing job stress. This, in turn, reduces nurses’ perceptions of quality of patient care they can provide. As previous research has found, decreased perceptions of quality of patient care is a significant factor driving intentions to leave the profession. The results demonstrated that WBHRM practices buffer the negative impact of fear of COVID-19 on job stress, and in turn, the perceived quality of patient care.

Originality/value

Our paper contributes to new knowledge for healthcare managers on WBHRM bundles and their efficacy in buffering the effects of fear on job stress and quality of patient care. We contribute new knowledge on fear at work and how to manage employees’ fear through WBHRM practices.
Competitive swimming and dental staining among Australian children
Authors: Patel J , Cai S , Huong B , Macdonald M , Anthonappa R
Published: September 2024

Background

Swimming has classically been associated with a distinctive type of extrinsic dental staining. However, its prevalence and characteristics have not been explored in Australia. This case controlled cross‐sectional cohort study aimed to determine the prevalence and severity of dental staining among children who swim competitively compared to non‐swimmers and its impact on oral health‐related quality of life (OHRQL).

Methods

Parents and children from Western Australian swimming clubs completed a survey assessing swimming routine, risk factors for staining and OHRQL. Intra‐oral photographs were taken and staining of anterior teeth was assessed using a modified Lobene Stain Index. A Global Stain Score (GSS) was calculated and compared against age‐matched non‐swimmer controls.

Results

Maxillary anterior teeth from swimmers (n = 400) and non‐swimmers (n = 400) were analysed. Staining prevalence was greater in swimmers (83%) than non‐swimmers (44%). GSS scores were positively correlated with both the total lifetime swimming hours and practice time (P < 0.05), with a significant difference in GSS between swimmers and non‐swimmers (P = <0.001, OR: 6.21). Dietary factors for staining were not significantly correlated with GSS.

Conclusion

Swimmers had a greater risk of developing staining than non‐swimmers, and this negatively impacted their OHRQL. The extent and intensity of staining were associated with the amount of swimming.
The influence of therapy quality on outcomes from behavioural activation and guided self‐help treatments for depression in adults with intellectual disabilities
Authors: Dagnan Dave , Thompson Paul , Hastings Richard P , Hatton Chris , Melville Chris , Cooper Sally‐Ann , McMeekin Nicola , Fulton Lauren , Jones Rob S. P. , McConnachie Alex , Jahoda Andrew
Published: September 2024

Objectives

We report the effect of quality of therapy delivery on outcomes in a randomized, controlled trial of behavioural activation (BA) and guided self‐help (GSH) for depression in adults with intellectual disabilities.

Methods

A study specific measure of quality was used in a linear mixed effect model to determine the effects therapy and therapy quality on therapy outcome.

Results

There was a significant interaction between quality and treatment type, with lower quality therapy associated with better outcome for GSH but poorer outcome for BA, with little difference in outcomes at higher levels of therapy quality.

Conclusions

Factors suggesting high quality in individualized BA may indicate problematic engagement for GSH. More research into processes in therapy for people with intellectual disabilities is required.
Cold tolerance of biological control agents Amblydromalus limonicus and Iphiseius degenerans
Authors: Mbaka Samuel Musyoka , Vasconcelos Sasha , Rezai Mohammad Hosein , Karlsson Miriam Frida , Jonsson Mattias
Published: September 2024

Knowledge about cold tolerance of non‐native biological control agents is critical to avoid permanently establishing them in new temperate areas outside of their native range. The cold tolerance of the predatory mites, Amblydromalus limonicus and Iphiseius degenerans, was investigated in the laboratory to assess their establishment potential in northern Europe, particularly Sweden. The lethal time of I. degenerans (the number of days until 100% mortality was reached) declined steeply from 5°C to 0°C and was almost zero at −5°C. The lethal time of A. limonicus did not differ between 5°C and 0°C, but was reduced at −5°C. For both species, LTime50 (the number of days until 50% of the mites died) was longer for fed than for unfed mites. The lethal temperature of A. limonicus (the temperature at which 100% mortality was reached) was −17.75°C, whereas most I. degenerans died at −8.5°C. LTemp50 (the temperature at which 50% of the mites died) was lower for A. limonicus (−9.8°C) than for I. degenerans (−0.1°C). Collectively, these findings suggest that I. degenerans is unlikely to establish in Sweden but that A. limonicus is more cold tolerant. This highlights the risk associated with releasing A. limonicus in Sweden due to concerns about potential establishment.
A Deconstructionist Theology of the Shoah by Hélène Cixous in Light of Derrida and Levinas: Theodicy, Job and Exile in From Osnabrück to Jerusalem
Authors: Feldmann‐Kaye Miriam
Published: September 2024

The primary objective of this study is to offer an original interpretation in two fields of research: the first, of contemporary Jewish philosophy, and the second, to the continental and specifically deconstructionist method. I wish to achieve this by analysing a new deconstructionist text of the French, Jewish, post‐structuralist, feminist contemporary thinker—Hélène Cixous, which has thus far received little scholarly attention at all, and even less in its contributions to deconstructionism and Jewish philosophical thought. Focusing on this text, I concentrate on its Jewish and philosophical aspects—Gare d'Osnabrück à Jérusalem—The Osnabrück Station in/to Jerusalem.

This study will centre on Cixous’ treatment of theodicy—the theological problem of evil and suffering—contextualising her position in the thought of the post‐war French cultural milieu of Emmanuel Levinas and Jacques Derrida. I will examine the position Cixous develops on theodicy—which is to resist it, and move towards a position of anti‐theodicy. I show how she develops this position, which is through a deconstructionist and hermeneutical reading of the biblical figure of Job. I then trace further theological issues arising from her anti‐theodicy, of the roles of exile and return in this text—especially in Cixous’ positioning of Osnabrück as ‘Jerusalem’. The study is set alongside the ‘Hauntology’ theory of Jacques Derrida. I claim that Cixous’ work can be enhanced through a hauntological reading, but that she ultimately re‐defines this position to advance her own thinking. This study offers questions beyond this particular text: first, relating to the role of deconstructionism in portraying theological issues, especially theodicy, and second, of the contributions, complex as they may be, to contemporary Jewish philosophical discourse.
Impact of recent criteria changes for the deferral criteria specific to men who have sex with men in France
Authors: Sauvage Claire , Laperche S. , Corominas V. , Stefic K. , Le Cam S. , Pouchol É. , Morel P. , Tiberghien P. , Lot F.
Published: September 2024

Background and Objectives

In 2016, France allowed men who have sex with men (MSM) to donate blood if they had not had sex with men in the previous 12 months. In April 2020, this restriction was relaxed to 4 months due to the lack of negative impact observed on blood safety. This study assesses the impact of reducing this deferral period on epidemiological surveillance indicators.

Materials and Methods

This study compares infection surveillance indicators between two 30‐month periods before (P1) and after (P2) this second deferral change.

Results

Overall, 79 donations tested positive for human immunodeficiency virus (HIV) (49 in P1 and 30 in P2), 322 for hepatitis C virus (HCV) (185 and 137), 622 for hepatitis B virus (HBV) (355 and 267) and 1684 for syphilis (799 and 885). Positive donation rates decreased between P1 and P2, except for syphilis: HIV (0.07/10,000 donations vs. 0.04; p > 0.5), HCV (0.25 vs. 0.20; p < 0.05), HBV (0.49 vs. 0.39; p < 0.01) and syphilis (1.10 vs. 1.29; p < 0.001). For all three viruses, residual risks of transmission by transfusion did not increase: HIV (1/7,800,000 donations vs. 1/10,500,000), HCV (1/25,200,000 vs. 1/47,300,000) and HBV (1/6,400,000 vs. 1/6,000,000).

Conclusion

Reducing the deferral period for MSM in April 2020 did not negatively impact residual risks, which remained very low, or the rate of positive donations, except for syphilis, which requires careful monitoring. To ensure equal access to blood donation, MSM have been allowed to donate blood under the same conditions as other donors since March 2022 (i.e., no more than one sexual partner in the last 4 months).
A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in
Drosophila
Authors: Zak Hila , Rozenfeld Eyal , Levi Mali , Deng Patricia , Gorelick David , Pozeilov Hadar , Israel Shai , Paas Yoav , Paas Yoav , Li Jin Billy , Parnas Moshe , Shohat-Ophir Galit
Published: September 2024

A-to-I RNA editing is a cellular mechanism that generates transcriptomic and proteomic diversity, which is essential for neuronal and immune functions. It involves the conversion of specific adenosines in RNA molecules to inosines, which are recognized as guanosines by cellular machinery. Despite the vast number of editing sites observed across the animal kingdom, pinpointing critical sites and understanding their in vivo functions remains challenging. Here, we study the function of an evolutionary conserved editing site in
Drosophila
, located in glutamate-gated chloride channel (
GluCl
α). Our findings reveal that flies lacking editing at this site exhibit reduced olfactory responses to odors and impaired pheromone-dependent social interactions. Moreover, we demonstrate that editing of this site is crucial for the proper processing of olfactory information in projection neurons. Our results highlight the value of using evolutionary conservation as a criterion for identifying editing events with potential functional significance and paves the way for elucidating the intricate link between RNA modification, neuronal physiology, and behavior.
A Delphi Study on the Changes in Work, Organizational Culture, and Health Issues of Nurses at Tertiary Hospitals in South Korea during the COVID‐19 Pandemic
Authors: Yun MiRa , Kim WonJong , Yu Boas , Choi Eun-Hi
Published: September 2024

Nurses in South Korea experience high work intensity and poor working environments, which worsened during the COVID‐19 pandemic. This study aimed to evaluate the work changes and grievances of nurses who provided direct care for patients at tertiary hospitals during the pandemic. The nurses’ perceptions of their organizational culture and its impact on nurses’ health were also explored. A three‐round Delphi study was conducted with 36 expert group participants from six South Korean tertiary hospitals. Overall, 36, 35, and 33 participants responded in the first, second, and third rounds, respectively. Nursing work was divided into three categories: “work related to COVID‐19‐positive and close contacts,” “work related to COVID‐19 negative patients,” and “work related to common nursing tasks.” Organizational culture had the highest average for “increased compliance,” followed by “increased conflict,” “decreased collegiality,” and “growing sense of community.” The identified health problems of nurses during the pandemic were the highest for physical health, followed by mental and social health. These results showed that the workload and work intensity of hospital nurses increased significantly, and their physical, mental, and social health deteriorated during the pandemic. To overcome the crisis, the nursing organizational culture had a strong inclination to comply with the COVID‐19‐related guidelines with an increased sense of community. As conflicts between employees and departments grew, these were able to be overcome through trust and communication between departments, in which the nursing leadership played an important role. To protect the health and lives of people, it is important to secure skilled nurses in preparation for future disasters. In addition, support is needed to protect the safety and health of nurses and to cultivate effective nursing leadership.
Capacidades y bienestar financiero. Evidencia para Chile y economías emergentes de América Latina
Authors: Huenchumarian Saavedra Mauricio Andrés
Published: September 2024

La investigación se centra en el análisis del bienestar financiero. El estudio se realizó a partir de fuentes bibliográficas y de datos de siete países que fueron recolectados de la encuesta sobre capacidades financieras realizada por el Banco de Desarrollo de América Latina. Como principales hallazgos de Chile se establece sobre los elementos centrales del bienestar financiero que los habitantes de zonas rurales tienen un mayor control sobre sus finanzas diarias y están encaminados a sus metas financieras, mientras que los habitantes de zonas urbanas tienen una mayor capacidad de absorber un choque financiero. Respecto del análisis comparativo de países de América se concluye que los habitantes de Chile tienen un gran control sobre sus finanzas diarias, una sólida capacidad de absorber un choque financiero, están bien encaminados a sus metas financieras y poseen una considerable libertad financiera para la toma de decisiones financieras que le permiten disfrutar la vida.
Supplementary Table S2 from Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer
Authors: Menegollo Michela , Bentham Robert B. , Henriques Tiago , Ng Seow Q. , Ren Ziyu , Esculier Clarinde , Agarwal Sia , Tong Emily T.Y. , Lo Clement , Ilangovan Sanjana , Szabadkai Zorka , Suman Matteo , Patani Neill , Ghanate Avinash , Bryson Kevin , Stein Robert C. , Yuneva Mariia , Szabadkai Gyorgy
Published: September 2024

Supplementary Table S2
Figure 5 from Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer
Authors: Menegollo Michela , Bentham Robert B. , Henriques Tiago , Ng Seow Q. , Ren Ziyu , Esculier Clarinde , Agarwal Sia , Tong Emily T.Y. , Lo Clement , Ilangovan Sanjana , Szabadkai Zorka , Suman Matteo , Patani Neill , Ghanate Avinash , Bryson Kevin , Stein Robert C. , Yuneva Mariia , Szabadkai Gyorgy
Published: September 2024

Metabolic wiring of the switch positions probed by 13C-labeled substrates. A, Nutrient supply and 13C-labeling conditions. High and low glutamine (H/L = 1/0.1 mmol/L) levels were combined with the presence and absence of pyruvate (+/−, 1/0 mmol/L), and glucose was kept at 10 mmol/L. B, Glucose uptake, lactate secretion, and fractional enrichment of m + 3 labeled intracellular lactate. Cells were grouped by switch state. Two-way ANOVA with Sidak multiple comparisons test. C, Fractional enrichment of the m+3 pyruvate isotopomer, following U13C-glucose labeling for 24 hours, in cells grouped by switch state. Two-way ANOVA with Sidak multiple comparison tests. D, Overall model of the MB1_UF/MB1_LF metabolic switch in central carbon metabolism. E, Relative carbon contribution to citrate following 24 hours labeling with U13C-glucose and U13C-glutamine, in cells grouped by switch state. Two-way ANOVA with Sidak multiple comparison tests. F, Fractional enrichment of the m+2 (PDH route; left) and m+5 (PDH + PC route; right) isotopologues in citrate following 24 hours labeling with U13C-glucose, in cells grouped by switch state. Two-way ANOVA with uncorrected Fisher LSD multiple comparison tests. G, Glutamine uptake, glutamate secretion, and fractional enrichment of malate m+4 (oxidative route) and citrate m+5 (reductive carboxylation) isotopologues following 24 hours labeling with U13C- glutamine (right panels). Two-way ANOVA with uncorrected Fisher LSD multiple comparison tests. H, Substrate dependence of basal oxygen consumption rate and total cellular ATP content in cells grouped by switch state. Two-way ANOVA with uncorrected Fisher LSD multiple comparison tests. ns, nonsignificant, P > 0.05; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.00; ****, P ≤ 0.0001.
Figure 4 from Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer
Authors: Menegollo Michela , Bentham Robert B. , Henriques Tiago , Ng Seow Q. , Ren Ziyu , Esculier Clarinde , Agarwal Sia , Tong Emily T.Y. , Lo Clement , Ilangovan Sanjana , Szabadkai Zorka , Suman Matteo , Patani Neill , Ghanate Avinash , Bryson Kevin , Stein Robert C. , Yuneva Mariia , Szabadkai Gyorgy
Published: September 2024

Mitochondrial function: MB1_UF cells show active functional biogenesis in contrast to the MB1_LF phenotype. A, Two-dimensional distribution (PC1 vs. ranking index, shown for the MB1 bicluster switch) of biopsies obtained for generating PDX samples from the study by Bruna and colleagues (38), overlaid in left panel with Pam50 categories and in the right panel with PDX status indicating whether the sample has grown from the biopsy to PDX status. B, Cell line scoring to sort cell lines to the MB1 switches. Volcano plot of the scores and −log10 of the P values are shown. The cell lines chosen for experimental work are highlighted in red. C, OCR in cell lines grouped by their switch state (MB1_UF/MB1_LF). Reserve, ATP synthesis coupled, and uncoupled respirations were quantified using FCCP and oligomycin treatments. Two-way ANOVA with Sidak multiple comparisons test. D, Average cellular TMRM intensity grouped by cell line switch state (MB1_UF/MB1_LF). Data were obtained from high content microscopy from >1K cells per group. Unpaired Student t test. E, Relative expression of respiratory chain subunits quantified from Western blot analysis. Results are grouped by switch state (MB1_UF/MB1_LF). Two-way ANOVA with Sidak multiple comparisons test. F, High content imaging analysis of mitochondrial biogenesis, structure, and function in MB1_UF and MB1_LF cells. Scale bars, 10 μm. Quantifications of the picoGreen integrated intensity (readout for mtDNA content), mitochondrial number, total volume, and individual mitochondrial volume are shown. Unpaired Student t tests. ns, nonsignificant, P > 0.05; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001.
Supplementary Tables from WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma
Authors: Li Li , Xie Dacheng , Yu Shijun , Ma Muyuan , Fan Kailing , Chen Jingde , Xiu Mengxi , Xie Keping , Li Yandong , Gao Yong
Published: September 2024

Supplementary Tables
Supplementary Figure S9 from WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma
Authors: Li Li , Xie Dacheng , Yu Shijun , Ma Muyuan , Fan Kailing , Chen Jingde , Xiu Mengxi , Xie Keping , Li Yandong , Gao Yong
Published: September 2024

Supplementary Figure S9
Supplementary Figure S4 from WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma
Authors: Li Li , Xie Dacheng , Yu Shijun , Ma Muyuan , Fan Kailing , Chen Jingde , Xiu Mengxi , Xie Keping , Li Yandong , Gao Yong
Published: September 2024

Supplementary Figure S4
Supplementary Figure 5 from Comprehensive Proteogenomic Profiling Reveals the Molecular Characteristics of Colorectal Cancer at Distinct Stages of Progression
Authors: Li Lingling , Jiang Dongxian , Liu Hui , Guo Chunmei , Zhang Qiao , Li Xuedong , Chen Xiaojian , Chen Zheqi , Feng Jinwen , Tan Subei , Huang Wen , Huang Jie , Xu Chen , Liu Chen-Ying , Yu Wei , Hou Yingyong , Ding Chen
Published: September 2024

Supplementary Figure 5 and related legend of the revised manuscript.
Supplementary Figure from PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT
Authors: Zhang Wenchao , Li Wei , Yin Chi , Feng Chengyao , Liu Binfeng , Xu Haodong , Jin Xin , Tu Chao , Li Zhihong
Published: September 2024

Supplementary Figures of the manuscript
Supplementary Data from PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT
Authors: Zhang Wenchao , Li Wei , Yin Chi , Feng Chengyao , Liu Binfeng , Xu Haodong , Jin Xin , Tu Chao , Li Zhihong
Published: September 2024

Supplementary Table of the manuscript
Table S2 from HPN328, a Trispecific T Cell–Activating Protein Construct Targeting DLL3-Expressing Solid Tumors
Authors: Molloy Mary E. , Aaron Wade H. , Barath Manasi , Bush Mabel C. , Callihan Evan C. , Carlin Kevin , Cremin Michael , Evans Thomas , Guerrero Maria G. , Hemmati Golzar , Hundal Avneel S. , Lao Llewelyn , Laurie Payton , Lemon Bryan D. , Lin S.J. , O’Rear Jessica , Patnaik Purbasa , Sotelo Rocha Sony , Santiago Linda , Strobel Kathryn L. , Valenzuela Laura B. , Wu Chi-Heng , Yu Stephen , Yu Timothy Z. , Anand Banmeet S. , Law Che-Leung , Sun Liping L. , Wesche Holger , Austin Richard J.
Published: September 2024

Antibodies used for immunophenotyping hCD3ε syngeneic model.
Figure S8 from HPN328, a Trispecific T Cell–Activating Protein Construct Targeting DLL3-Expressing Solid Tumors
Authors: Molloy Mary E. , Aaron Wade H. , Barath Manasi , Bush Mabel C. , Callihan Evan C. , Carlin Kevin , Cremin Michael , Evans Thomas , Guerrero Maria G. , Hemmati Golzar , Hundal Avneel S. , Lao Llewelyn , Laurie Payton , Lemon Bryan D. , Lin S.J. , O’Rear Jessica , Patnaik Purbasa , Sotelo Rocha Sony , Santiago Linda , Strobel Kathryn L. , Valenzuela Laura B. , Wu Chi-Heng , Yu Stephen , Yu Timothy Z. , Anand Banmeet S. , Law Che-Leung , Sun Liping L. , Wesche Holger , Austin Richard J.
Published: September 2024

FACS Binding of HPN328 to DLL3+ cells and T cells.
Figure S4 from HPN328, a Trispecific T Cell–Activating Protein Construct Targeting DLL3-Expressing Solid Tumors
Authors: Molloy Mary E. , Aaron Wade H. , Barath Manasi , Bush Mabel C. , Callihan Evan C. , Carlin Kevin , Cremin Michael , Evans Thomas , Guerrero Maria G. , Hemmati Golzar , Hundal Avneel S. , Lao Llewelyn , Laurie Payton , Lemon Bryan D. , Lin S.J. , O’Rear Jessica , Patnaik Purbasa , Sotelo Rocha Sony , Santiago Linda , Strobel Kathryn L. , Valenzuela Laura B. , Wu Chi-Heng , Yu Stephen , Yu Timothy Z. , Anand Banmeet S. , Law Che-Leung , Sun Liping L. , Wesche Holger , Austin Richard J.
Published: September 2024

Binding of HPN328 to DLL3, albumin and CD3e.
Figure S3 from HPN328, a Trispecific T Cell–Activating Protein Construct Targeting DLL3-Expressing Solid Tumors
Authors: Molloy Mary E. , Aaron Wade H. , Barath Manasi , Bush Mabel C. , Callihan Evan C. , Carlin Kevin , Cremin Michael , Evans Thomas , Guerrero Maria G. , Hemmati Golzar , Hundal Avneel S. , Lao Llewelyn , Laurie Payton , Lemon Bryan D. , Lin S.J. , O’Rear Jessica , Patnaik Purbasa , Sotelo Rocha Sony , Santiago Linda , Strobel Kathryn L. , Valenzuela Laura B. , Wu Chi-Heng , Yu Stephen , Yu Timothy Z. , Anand Banmeet S. , Law Che-Leung , Sun Liping L. , Wesche Holger , Austin Richard J.
Published: September 2024

HPN328 directs T cell killing in the presence of DLL3 positive DMS 53 and NCI-H2171 cells.
Figure S15 from HPN328, a Trispecific T Cell–Activating Protein Construct Targeting DLL3-Expressing Solid Tumors
Authors: Molloy Mary E. , Aaron Wade H. , Barath Manasi , Bush Mabel C. , Callihan Evan C. , Carlin Kevin , Cremin Michael , Evans Thomas , Guerrero Maria G. , Hemmati Golzar , Hundal Avneel S. , Lao Llewelyn , Laurie Payton , Lemon Bryan D. , Lin S.J. , O’Rear Jessica , Patnaik Purbasa , Sotelo Rocha Sony , Santiago Linda , Strobel Kathryn L. , Valenzuela Laura B. , Wu Chi-Heng , Yu Stephen , Yu Timothy Z. , Anand Banmeet S. , Law Che-Leung , Sun Liping L. , Wesche Holger , Austin Richard J.
Published: September 2024

TriTAC mediated cytotoxic activity in vitro and in vivo in the hCD3ε mouse model.
Supplementary Figure 2 from Prognostic Significance of SASP-Related Gene Signature of Radiation Therapy in Head and Neck Squamous Cell Carcinoma
Authors: Lee Min Kyeong , Woo Seon Rang , Noh Joo Kyung , Min Soonki , Kong Moonkyoo , Lee Young Chan , Ko Seong-Gyu , Eun Young-Gyu
Published: September 2024

Supplementary figure 2. Pathway analysis (A) Pathway analysis of SASP-related gene signature based on Protein–protein interaction network. The PPI confidence score lower than 0.9 and genes in the network with at least 5 degrees were respectively set as significant. Subsequently, the PPI network with scores> 5, node ≥ counts 5, node score = 0.2, and maximum depth = 100 as cut-off criteria. (B) Enrichment pathway of SASP-related gene signature based on GESA analysis. The human-ENSEMBLE-Gene-MsigDB chip was selected as the chip platform. FDR less than 0.05 after 1,000 random permutations were set as the cut-off criterion. (C) TNF-alpha signaling via NF-kappa B was enriched in cluster 1 of SASP-related gene signature (FDR <0.05) and G2M checkpoint enriched in cluster 2 of SASP-related gene signature (FDR <0.05) The enrichment score (y-axis) is shown. The top portion of the plot shows the ES (green line). (D) The ranked list of genes in TNF-alpha signaling via NF-kappa B of cluster1 (Right) and the ranked list of genes in the G2M checkpoint of cluster2 (Left) are shown.
Figure S3 from Pretargeted Radioimmunotherapy with the Novel Anti-oxMIF/HSG Bispecific Antibody ON105 Results in Significant Tumor Regression in Murine Models of Cancer
Authors: Puchol Tarazona Alejandro A. , Schinagl Alexander , Mirkina Irina , Rossmueller Gregor , Kerschbaumer Randolf J. , Bachmann Friedmund , Thiele Michael
Published: September 2024

Figure S3
Supplementary Figure S3 from A Senescence-Mimicking (Senomimetic) VEGFR TKI Side Effect Primes Tumor Immune Responses via IFN/STING Signaling
Authors: Dolan Melissa , Shi Yuhao , Mastri Michalis , Long Mark D. , McKenery Amber , Hill James W. , Vaghi Cristina , Benzekry Sebastien , Barbi Joseph , Ebos John M.L.
Published: September 2024

Figure S3: Extended data for Fig 3 - SM expression can be regulated by a STING-IFNβ signaling axis. (A-C) Tables summarizing statistical comparisons for densitometry analysis of western blots from (A) Log2FC in expression levels compared to 4T1P controls in Fig 3A, (B) Log2FC in expression levels compared to vehicle-treated control in Fig 3D, and (C) Log2FC in expression levels in EMT6M and EMT6CaR vs. vehicle controls in Fig 3J (n=3 for all; Supplemental Data File 3 shows blotting replicates) (D) Protein expression analysis of the STING pathway in EMT6M tumor cells following treatment with Ax, Ca, or DMXAA evaluated by western blot (n=2-3). (E) Table summarizing statistical comparisons for densitometry analysis of western blot from Fig S3D. (F-G) Ifnb gene expression evaluated by qRT-PCR in: (F) 4T1AxR vs. 4T1P (n=3). (G) EMT6CaR vs. EMT6M (n=3). (H) Log2FC comparison of SM expression in EMT6shCon or EMT6IFNAR1-KD cells before and after Ax or Ca treatment as shown in Fig 3O (n=3). Metastatic parental control for EMT6CaR (EMT6M); Parental (P); shRNA Vector control (shCon); Axitinib-resistant (AxR); Cabozantinib-resistant (CaR); Interferon-beta (Ifnβ); Type I IFN receptor knockdown (IFNAR1-KD); Standard deviation (SD); Drug concentrations for SN-011 (6µM), MSA-2 (33µM), DMXAA (50µM), Ax (0.5µM), Ca (2µM), Su (2µM), Tivo (2µM), Pazo (2µM), and Lenv (2µM). Quantitative data is shown as mean ± SD; * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001.
Supplementary Figure S1 from A Senescence-Mimicking (Senomimetic) VEGFR TKI Side Effect Primes Tumor Immune Responses via IFN/STING Signaling
Authors: Dolan Melissa , Shi Yuhao , Mastri Michalis , Long Mark D. , McKenery Amber , Hill James W. , Vaghi Cristina , Benzekry Sebastien , Barbi Joseph , Ebos John M.L.
Published: September 2024

Figure S1: Extended data for Fig 1 - Enriched IFN signaling in SM+ tumor cells after VEGFR TKI treatment. (A) In vivo derivation of 4T1AxR lung metastasis taken from mice after surgical resection of orthotopically implanted 4T1 cells and following Ax treatment (100mg/kg/day). Described in 7. (B) Proliferation analysis of 4T1 cells after treatment with multiple VEGFR TKIs. IC50 values indicated in red. (MTS assay; n = 3-4) (C) In vivo derivation of a Ca-resistant mouse breast tumor cell line EMT6 (EMT6CaR) and vehicle-treated control (EMT6M) taken from lung metastasis of Balb/c mice after orthotopic implantation of EMT6 and following Ca (30mg/kg/day) or vehicle treatment. (D-E) EMT6CaR cells showed increases (compared to EMT6M controls) in D) SM expression (by flow cytometry; n=6) and E) ISG expression (by qRT-PCR; n=3). (F) Proliferation analysis of EMT6M cells after Ca and Ax treatment to choose optimal dosing. IC50 values indicated in red. (MTS assay; n = 3-4) (G-I) SM expression after Ax or Ca treatment in (F) EMT6M, (G) RENCA, and (H) LM2-4 cells (flow cytometry; n=3-6). (J-L) ISG expression after Ca treatment in (I) EMT6M, (J) 4T1, and (K) LM2-4 cells (qRT-PCR; n=3). (M) ISG expression after Ax treatment in EMT6M cells (qRT-PCR; n=3). Parental (P), Axitinib (Ax), Cabozantinib (Ca), Short-term (ST), Vehicle (Veh), Fold Change (FC); Interferon-stimulated genes (ISGs); 5-Dodecanoylaminofluorescein Di-β-D-Galactopyranoside (C12FDG); Standard deviation (SD); Drug concentration for Ax (0.5µM for F and L; 2µM for G and K) and Ca (2µM for F, G, I and J; 5µM for H and K); #, indicates experiment terminated. Quantitative data is shown as mean ± SD; * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001.
Figure S2 from IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion
Authors: Li Ji , Clark Robyn , Slaga Dionysos , Avery Kendra , Liu Ke , Schubbert Suzanne , Varma Rajat , Chiang Eugene , Totpal Klara , Bernett Matthew J. , Holder Patrick G. , Junttila Teemu T.
Published: September 2024

Supplementary figure S2 shows anti-HER-2/CD3 TDB-induced CD122 upregulation
Supplementary Figure S7 from Combining EHMT and PARP Inhibition: A Strategy to Diminish Therapy-Resistant Ovarian Cancer Tumor Growth while Stimulating Immune Activation
Authors: Nguyen Lily L. , Watson Zachary L. , Ortega Raquel , Woodruff Elizabeth R. , Jordan Kimberly R. , Iwanaga Ritsuko , Yamamoto Tomomi M. , Bailey Courtney A. , To Francis , Jeong Abigail D. , Guntupalli Saketh R. , Behbakht Kian , Gibaja Veronica , Arnoult Nausica , Cocozaki Alexis , Chuong Edward B. , Bitler Benjamin G.
Published: September 2024

Supplementary Figure S7 shows the analysis from the multispectral immunohistochemistry of ex vivo tumors treated with single agents and in combination.
Supplementary Figure S1 from Combining EHMT and PARP Inhibition: A Strategy to Diminish Therapy-Resistant Ovarian Cancer Tumor Growth while Stimulating Immune Activation
Authors: Nguyen Lily L. , Watson Zachary L. , Ortega Raquel , Woodruff Elizabeth R. , Jordan Kimberly R. , Iwanaga Ritsuko , Yamamoto Tomomi M. , Bailey Courtney A. , To Francis , Jeong Abigail D. , Guntupalli Saketh R. , Behbakht Kian , Gibaja Veronica , Arnoult Nausica , Cocozaki Alexis , Chuong Edward B. , Bitler Benjamin G.
Published: September 2024

Supplementary Figure S1 shows the EHMT-inhibition mediated loss of H3K9Me2 in the different HGSC models. It also shows the transcriptional changes via volcano plot and pathway analysis due to the treatment of single treatments and combination treatments.
Supplementary Figure 8 from Enhancing Neutrophil Cytotoxicity of a Panel of Clinical EGFR Antibodies by Fc Engineering to IgA3.0
Authors: Chan Chilam , Jansen J.H. Marco , Hendriks Ilona S.T. , van der Peet Ida C. , Verdonschot Meggy E.L. , Passchier Elsemieke M. , Tsioumpekou Maria , Nederend Maaike , Klomp Sharon A. , Valerius Thomas , Peipp Matthias , Leusen Jeanette H.W. , Olofsen Patricia A.
Published: September 2024

Supplementary Figure 8: Internalization of IgA3.0 EGFR antibodies.
Supplementary Figure 4 from Enhancing Neutrophil Cytotoxicity of a Panel of Clinical EGFR Antibodies by Fc Engineering to IgA3.0
Authors: Chan Chilam , Jansen J.H. Marco , Hendriks Ilona S.T. , van der Peet Ida C. , Verdonschot Meggy E.L. , Passchier Elsemieke M. , Tsioumpekou Maria , Nederend Maaike , Klomp Sharon A. , Valerius Thomas , Peipp Matthias , Leusen Jeanette H.W. , Olofsen Patricia A.
Published: September 2024

Supplementary Figure 4: IgA3.0 EGFR mitigated tumor burden in a short intraperitoneal EL4 tumor model.
Supplementary Figure 3 from Enhancing Neutrophil Cytotoxicity of a Panel of Clinical EGFR Antibodies by Fc Engineering to IgA3.0
Authors: Chan Chilam , Jansen J.H. Marco , Hendriks Ilona S.T. , van der Peet Ida C. , Verdonschot Meggy E.L. , Passchier Elsemieke M. , Tsioumpekou Maria , Nederend Maaike , Klomp Sharon A. , Valerius Thomas , Peipp Matthias , Leusen Jeanette H.W. , Olofsen Patricia A.
Published: September 2024

Supplementary Figure 3: Tumor outgrowth in A431-luc2 tumor-bearing mice.
Supplementary Figure S2 from Crizotinib Enhances PARP Inhibitor Efficacy in Ovarian Cancer Cells and Xenograft Models by Inducing Autophagy
Authors: Santiago-O’Farrill Janice M. , Blessing Bollu Alicia , Yang Hailing , Orellana Vivian , Pina Marc , Zhang Xudong , Liu Jinsong , Bast Robert C. , Lu Zhen
Published: September 2024

Supplementary Figure S2 shows dose response curves, colony formation assays and viability of Olaparib resistant cells treated with Olaparib and crizotinib
Supplementary Table 1 from Hepatitis B Virus X Protein Represses Expression of Tumor Suppressor PTPN18 in Hepatocellular Carcinoma
Authors: Zhou Zhenyu , Yu Wei , Li Huoming , Shi Juanyi , Meng Shiyu , Yan Yongcong , Chen Ruibin , Liu Haohan , Wang Jie , Sun Jian , Xiao Zhiyu , Zhang Jianlong
Published: September 2024

Patient's clinicopathologic features using in the IHC.
Supplementary Figure 2 from Hepatitis B Virus X Protein Represses Expression of Tumor Suppressor PTPN18 in Hepatocellular Carcinoma
Authors: Zhou Zhenyu , Yu Wei , Li Huoming , Shi Juanyi , Meng Shiyu , Yan Yongcong , Chen Ruibin , Liu Haohan , Wang Jie , Sun Jian , Xiao Zhiyu , Zhang Jianlong
Published: September 2024

Kaplan–Meier survival analysis based on the PTPN18 mRNA expression in our center's cohort.
Figure S5 from Intrinsic Epigenetic State of Primary Osteosarcoma Drives Metastasis
Authors: Singh Irtisha , Rainusso Nino , Kurenbekova Lyazat , Nirala Bikesh K. , Dou Juan , Muruganandham Abhinaya , Yustein Jason T.
Published: September 2024

Differential chromatin activity shapes transcriptional profile.
Figure S3 from Intrinsic Epigenetic State of Primary Osteosarcoma Drives Metastasis
Authors: Singh Irtisha , Rainusso Nino , Kurenbekova Lyazat , Nirala Bikesh K. , Dou Juan , Muruganandham Abhinaya , Yustein Jason T.
Published: September 2024

Gene alteration frequency of PREX1.
Figure S7 from Mechanisms of Glioblastoma Replication: Ca2+ Flares and Cl− Currents
Authors: Li Yunzhen , Sanchez Triviño Cesar Adolfo , Hernandez Andres , Mortal Simone , Spada Federica , Krivosheia Ilona , Franco Nicoletta , Spelat Renza , Cesselli Daniela , Manini Ivana , Skrap Miran , Menini Anna , Cesca Fabrizia , Torre Vincent
Published: September 2024

VRAC-like currents are observed in patient-derived GSCs.
Figure S6 from Mechanisms of Glioblastoma Replication: Ca2+ Flares and Cl− Currents
Authors: Li Yunzhen , Sanchez Triviño Cesar Adolfo , Hernandez Andres , Mortal Simone , Spada Federica , Krivosheia Ilona , Franco Nicoletta , Spelat Renza , Cesselli Daniela , Manini Ivana , Skrap Miran , Menini Anna , Cesca Fabrizia , Torre Vincent
Published: September 2024

Comparison of electrical properties of flat and rounded U87 cells.
Supplementary Figure S3 from USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming
Authors: Ekstrom Thomas L. , Hussain Sajjad , Bedekovics Tibor , Ali Asma , Paolini Lucia , Mahmood Hina , Rosok Raya M. , Koster Jan , Johnsen Steven A. , Galardy Paul J.
Published: September 2024

USP44 expression correlates with CIN in neuroblastoma.
Figure S10 from Mechanisms of Glioblastoma Replication: Ca2+ Flares and Cl− Currents
Authors: Li Yunzhen , Sanchez Triviño Cesar Adolfo , Hernandez Andres , Mortal Simone , Spada Federica , Krivosheia Ilona , Franco Nicoletta , Spelat Renza , Cesselli Daniela , Manini Ivana , Skrap Miran , Menini Anna , Cesca Fabrizia , Torre Vincent
Published: September 2024

Histochemical analysis of TMEM16A (A), TMEM16B (B), VRAC (C) and Piezo 1 (D) channels in flat / rounded U87 cells.
Figure S4 from MLLT6/ATF2 Axis Restrains Breast Cancer Progression by Driving DDIT3/4 Expression
Authors: Yu Qing , Zhao Jiayi , Yang Anli , Li Xiangxin
Published: September 2024

Supplementary Figure S4, referred to Figure 4.
Figure S3 from MLLT6/ATF2 Axis Restrains Breast Cancer Progression by Driving DDIT3/4 Expression
Authors: Yu Qing , Zhao Jiayi , Yang Anli , Li Xiangxin
Published: September 2024

Supplementary Figure S3, referred to Figure 3. MLLT6 overexpression positively correlates with the sensitization of breast cancer cells to apoptosis.
Data from Crizotinib Enhances PARP Inhibitor Efficacy in Ovarian Cancer Cells and Xenograft Models by Inducing Autophagy
Authors: Santiago-O’Farrill Janice M. , Blessing Bollu Alicia , Yang Hailing , Orellana Vivian , Pina Marc , Zhang Xudong , Liu Jinsong , Bast Robert C. , Lu Zhen
Published: September 2024

Abstract
Poly (ADP-ribose) polymerase inhibitors (PARPi) can encounter resistance through various mechanisms, limiting their effectiveness. Our recent research showed that PARPi alone can induce drug resistance by promoting autophagy. Moreover, our studies have revealed that anaplastic lymphoma kinase (ALK) plays a role in regulating the survival of ovarian cancer cells undergoing autophagy. Here, we explored whether the ALK-inhibitor crizotinib could enhance the efficacy of PARPi by targeting drug-induced autophagic ovarian cancer cell and xenograft models. Our investigation demonstrates that crizotinib enhances the anti-tumor activity of PARPi across multiple ovarian cancer cells. Combination therapy with crizotinib and olaparib reduced cell viability and clonogenic growth in two-olaparib resistant cell lines. More importantly, this effect was consistently observed in patient-derived organoids. Furthermore, combined treatment with crizotinib and olaparib led to tumor regression in human ovarian xenograft models. Mechanistically, the combination resulted in increased levels of reactive oxygen species (ROS), induced DNA damage, and decreased the phosphorylation of AKT, mTOR, and ULK-1, contributing to increased olaparib-induced autophagy and apoptosis. Notably, pharmacologic, or genetic inhibition or autophagy reduced the sensitivity of ovarian cancer cell lines to olaparib and crizotinib treatment, underscoring the role of autophagy in cell death. Blocking ROS mitigated olaparib/crizotinib-induced autophagy and cell death while restoring levels of phosphorylated AKT, mTOR and ULK-1. These findings suggest that crizotinib can improve the therapeutic efficacy of olaparib by enhancing autophagy.

Implications: The combination of crizotinib and PARPi presents a promising strategy, that could provide a novel approach to enhance outcomes for patients with ovarian cancer.
Supplementary Table S2 from Effect of Clonal Hematopoiesis Mutations and Canakinumab Treatment on Incidence of Solid Tumors in the CANTOS Randomized Clinical Trial
Authors: Woo Janghee , Zhai Tingting , Yang Fang , Xu Huilei , Healey Margaret L. , Yates Denise P. , Beste Michael T. , Steensma David P.
Published: September 2024

Supplementary Table S2 shows the summary of CH mutation status.
Supplementary Figure S2 from Effect of Clonal Hematopoiesis Mutations and Canakinumab Treatment on Incidence of Solid Tumors in the CANTOS Randomized Clinical Trial
Authors: Woo Janghee , Zhai Tingting , Yang Fang , Xu Huilei , Healey Margaret L. , Yates Denise P. , Beste Michael T. , Steensma David P.
Published: September 2024

Supplementary Figure S2 shows cumulative incidence of lung cancer by treatment in patients without CH mutations, stratified by the canakinumab dose.
Supplemental Figure 2 from Diet Modulates the Gut Microbiome, Metabolism, and Mammary Gland Inflammation to Influence Breast Cancer Risk
Authors: Arnone Alana A. , Wilson Adam S. , Soto-Pantoja David R. , Cook Katherine L.
Published: September 2024

Supplemental Figure 2: A. Representative unstained flow plot controls. B. Representative single-antibody controls.
Data from Diet Modulates the Gut Microbiome, Metabolism, and Mammary Gland Inflammation to Influence Breast Cancer Risk
Authors: Arnone Alana A. , Wilson Adam S. , Soto-Pantoja David R. , Cook Katherine L.
Published: September 2024

Abstract
Several studies indicate a strong link between obesity and the risk of breast cancer. Obesity decreases gut microbial biodiversity and modulates Bacteroidetes-to-Firmicutes phyla proportional abundance, suggesting that increased energy-harvesting capacity from indigestible dietary fibers and elevated lipopolysaccharide bioavailability may promote inflammation. To address the limited evidence linking diet-mediated changes in gut microbiota to breast cancer risk, we aimed to determine how diet affects the microbiome and breast cancer risk. For ten weeks, female 3-week-old BALB/c mice were fed six different diets (control, high-sugar, lard, coconut oil, lard + flaxseed oil, and lard + safflower oil). Fecal 16S sequencing was performed for each group. Diet shifted fecal microbiome populations and modulated mammary gland macrophage infiltration. Fecal-conditioned media shifted macrophage polarity and inflammation. In our DMBA-induced breast cancer model, diet differentially modulated tumor and mammary gland metabolism. We demonstrated how dietary patterns change metabolic outcomes and the gut microbiota, possibly contributing to breast tumor risk. Furthermore, we showed the influence of diet on metabolism, inflammation, and macrophage polarity. This study suggests that dietary–microbiome interactions are key mediators of breast cancer risk.

Prevention Relevance: Our study demonstrates the impact of diet on breast cancer risk, focusing on the interplay between diet, the gut microbiome, and mammary gland inflammation.
Supplementary Table S3 from CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma
Authors: Zhang Xu , Duan Shoufu , Apostolou Panagiota E. , Wu Xiaoping , Watanabe Jun , Gallitto Matthew , Barron Tara , Taylor Kathryn R. , Woo Pamelyn J. , Hua Xu , Zhou Hui , Wei Hong-Jian , McQuillan Nicholas , Kang Kyung-Don , Friedman Gregory K. , Canoll Peter D. , Chang Kenneth , Wu Cheng-Chia , Hashizume Rintaro , Vakoc Christopher R. , Monje Michelle , McKhann Guy M. , Gogos Joseph A. , Zhang Zhiguo
Published: September 2024

Analysis for shared DEGs between CHD2 and FOSL1 depletion in H3.1K27M DMG cells.
Supplementary Figure S7 from CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma
Authors: Zhang Xu , Duan Shoufu , Apostolou Panagiota E. , Wu Xiaoping , Watanabe Jun , Gallitto Matthew , Barron Tara , Taylor Kathryn R. , Woo Pamelyn J. , Hua Xu , Zhou Hui , Wei Hong-Jian , McQuillan Nicholas , Kang Kyung-Don , Friedman Gregory K. , Canoll Peter D. , Chang Kenneth , Wu Cheng-Chia , Hashizume Rintaro , Vakoc Christopher R. , Monje Michelle , McKhann Guy M. , Gogos Joseph A. , Zhang Zhiguo
Published: September 2024

CHD2 and FOSL1 regulate H3K27me3 and H3K27ac in H3.1K27M DMG cells.
Supplementary Figure S4 from CHD2 Regulates Neuron–Glioma Interactions in Pediatric Glioma
Authors: Zhang Xu , Duan Shoufu , Apostolou Panagiota E. , Wu Xiaoping , Watanabe Jun , Gallitto Matthew , Barron Tara , Taylor Kathryn R. , Woo Pamelyn J. , Hua Xu , Zhou Hui , Wei Hong-Jian , McQuillan Nicholas , Kang Kyung-Don , Friedman Gregory K. , Canoll Peter D. , Chang Kenneth , Wu Cheng-Chia , Hashizume Rintaro , Vakoc Christopher R. , Monje Michelle , McKhann Guy M. , Gogos Joseph A. , Zhang Zhiguo
Published: September 2024

CHD2 regulates neuron-induced proliferation of H3.1K27M DMG cells.
Table S3 from MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
Authors: Meena Jitendra K. , Wang Jarey H. , Neill Nicholas J. , Keough Dianne , Putluri Nagireddy , Katsonis Panagiotis , Koire Amanda M. , Lee Hyemin , Bowling Elizabeth A. , Tyagi Siddhartha , Orellana Mayra , Dominguez-Vidaña Rocio , Li Heyuan , Eagle Kenneth , Danan Charles , Chung Hsiang-Ching , Yang Andrew D. , Wu William , Kurley Sarah J. , Ho Brian M. , Zoeller Joseph R. , Olson Calla M. , Meerbrey Kristen L. , Lichtarge Olivier , Sreekumar Arun , Dacso Clifford C. , Guddat Luke W. , Rejman Dominik , Hocková Dana , Janeba Zlatko , Simon Lukas M. , Lin Charles Y. , Pillon Monica C. , Westbrook Thomas F.
Published: September 2024

Table S3 shows evolutionary Action analysis of tumor-derived mutation in DIS3L.
Figure S6 from MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
Authors: Meena Jitendra K. , Wang Jarey H. , Neill Nicholas J. , Keough Dianne , Putluri Nagireddy , Katsonis Panagiotis , Koire Amanda M. , Lee Hyemin , Bowling Elizabeth A. , Tyagi Siddhartha , Orellana Mayra , Dominguez-Vidaña Rocio , Li Heyuan , Eagle Kenneth , Danan Charles , Chung Hsiang-Ching , Yang Andrew D. , Wu William , Kurley Sarah J. , Ho Brian M. , Zoeller Joseph R. , Olson Calla M. , Meerbrey Kristen L. , Lichtarge Olivier , Sreekumar Arun , Dacso Clifford C. , Guddat Luke W. , Rejman Dominik , Hocková Dana , Janeba Zlatko , Simon Lukas M. , Lin Charles Y. , Pillon Monica C. , Westbrook Thomas F.
Published: September 2024

Figure S6 shows 6-mercaptopurine dose curve in various cell lines, effect of 6-mercaptopurine on purine catabolite abundance in TNBC cells, effect of XDH knockdown on 6-mercaptopurine induced cell death, and 6-mercaptopurine- induced effect on cell viability upon purine nucleotide supplementation.
Supplemental Table S3 from D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities
Authors: Zhang Jing , Lim Sun Min , Yu Mi Ra , Chen Cheng , Wang Jia , Wang Wenqian , Rui Haopeng , Lu Jingtao , Lu Shun , Mok Tony , Chen Zhi Jian , Cho Byoung Chul
Published: September 2024

Supplemental Table S3 summarizing the anti-tumor activity of D3S-001 in CDX, PDX or PDO xenograft models
Supplemental Figure S3 from D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities
Authors: Zhang Jing , Lim Sun Min , Yu Mi Ra , Chen Cheng , Wang Jia , Wang Wenqian , Rui Haopeng , Lu Jingtao , Lu Shun , Mok Tony , Chen Zhi Jian , Cho Byoung Chul
Published: September 2024

Supplemental Figure S3 shows pERK inhibition by KRAS G12C inhibitors with or without HGF.