bluuebunny/crossref_metadata_2025 huggingface dataset:
A Narrative Review of the Association between Post-Traumatic Stress Disorder and Obstructive Sleep Apnea
Authors: McCall Catherine A. , Watson Nathaniel F.
Published: January 2022

Obstructive sleep apnea (OSA) and post-traumatic stress disorder (PTSD) are often co-morbid with implications for disease severity and treatment outcomes. OSA prevalence is higher in PTSD sufferers than in the general population, with a likely bidirectional effect of the two illnesses. There is substantial evidence to support the role that disturbed sleep may play in the pathophysiology of PTSD. Sleep disturbance associated with OSA may interfere with normal rapid eye movement (REM) functioning and thus worsen nightmares and sleep-related movements. Conversely, hyperarousal and hypervigilance symptoms of PTSD may lower the arousal threshold and thus increase the frequency of sleep fragmentation related to obstructive events. Treating OSA not only improves OSA symptoms, but also nightmares and daytime symptoms of PTSD. Evidence suggests that positive airway pressure (PAP) therapy reduces PTSD symptoms in a dose-dependent fashion, but also presents challenges to tolerance in the PTSD population. Alternative OSA treatments may be better tolerated and effective for improving both OSA and PTSD. Further research avenues will be introduced as we seek a better understanding of this complex relationship.
Therapeutic Anticoagulation Impacts MR Morphologic Recurrence Patterns in Glioblastoma—A Matched-Pair Analysis
Authors: Dubinski Daniel , Won Sae-Yeon , Behmanesh Bedjan , Dosch Max , Puchinin Viktoria , Baumgarten Peter , Bernstock Joshua D. , Voss Martin , Schuss Patrick , Konczalla Jürgen , Czabanka Marcus , Freiman Thomas M. , Gessler Florian
Published: January 2022

Background: Glioblastoma (GBM) patients are at particularly high risk for thrombotic complications. In the event of a postoperative pulmonary embolism, therapeutic anticoagulation (tAC) is indispensable. The impact of therapeutic anticoagulation on recurrence pattern in GBM is currently unknown. Methods: We conducted a matched-pair cohort analysis of 57 GBM patients with or without tAC that were matched for age, sex, gross total resection and MGMT methylation status in a ratio of 1:2. Patients’ characteristics and clinical course were evaluated using medical charts. MRI characteristics were evaluated by two independent authors blinded to the AC status. Results: The morphologic MRI appearance in first GBM recurrence showed a significantly higher presence of multifocal, midline crossing and sharp demarcated GBM recurrence patterns in patients with therapeutic tAC compared to the matched control group. Although statistically non-significant, the therapeutic tAC cohort showed increased survival. Conclusion: Therapeutic anticoagulation induced significant morphologic changes in GBM recurrences. The underlying pathophysiology is discussed in this article but remains to be further elucidated.
First-Response ABCDE Management of Status Epilepticus: A Prospective High-Fidelity Simulation Study
Authors: Kliem Paulina S. C. , Tisljar Kai , Baumann Sira M. , Grzonka Pascale , De Marchis Gian Marco , Bassetti Stefano , Bingisser Roland , Hunziker Sabina , Marsch Stephan , Sutter Raoul
Published: January 2022

Respiratory infections following status epilepticus (SE) are frequent, and associated with higher mortality, prolonged ICU stay, and higher rates of refractory SE. Lack of airway protection may contribute to respiratory infectious complications. This study investigates the order and frequency of physicians treating a simulated SE following a systematic Airways-Breathing-Circulation-Disability-Exposure (ABCDE) approach, identifies risk factors for non-adherence, and analyzes the compliance of an ABCDE guided approach to SE with current guidelines. We conducted a prospective single-blinded high-fidelity trial at a Swiss academic simulator training center. Physicians of different affiliations were confronted with a simulated SE. Physicians (n = 74) recognized SE and performed a median of four of the five ABCDE checks (interquartile range 3–4). Thereof, 5% performed a complete assessment. Airways were checked within the recommended timeframe in 46%, breathing in 66%, circulation in 92%, and disability in 96%. Head-to-toe (exposure) examination was performed in 15%. Airways were protected in a timely manner in 14%, oxygen supplied in 69%, and antiseizure drugs (ASDs) administered in 99%. Participants’ neurologic affiliation was associated with performance of fewer checks (regression coefficient −0.49; p = 0.015). We conclude that adherence to the ABCDE approach in a simulated SE was infrequent, but, if followed, resulted in adherence to treatment steps and more frequent protection of airways.
Diagnosis of Mitral Valve Prolapse: Much More than Simple Prolapse. Multimodality Approach to Risk Stratification and Therapeutic Management
Authors: Alenazy Ali , Eltayeb Abdalla , Alotaibi Muteb K. , Anwar Muhammah Kashif , Mulafikh Norah , Aladmawi Mohammed , Vriz Olga
Published: January 2022

Mitral valve prolapse (MVP) is the most common valvular disease with a prevalence of 2%. It has generally a benign course; however, recent findings suggested an association between MVP and complex arrhythmias and eventually cardiac arrest and for this reason, it is also called arrhythmogenic MVP. Subjects who experience this complication are in general young women, with thickened mitral leaflets or bileaflet prolapse not necessarily associated with severe mitral regurgitation (MR). The nature of the relation between MVP and cardiac arrest is not clearly understood. Actually, the challenging task is to find the cluster of prognostic factors including T-wave inversion, polymorphic premature ventricular contractions, bileaflet prolapse, MR severity, but most importantly, those parameters of hypercontractility, mitral annulus disjunction (MAD), and myocardial fibrosis using a multimodality approach. Transthoracic echocardiography is the first-line imaging modality for the diagnosis of MVP, but also for detecting MAD and hypercontractility, followed by cardiac magnetic resonance for tissue characterization and detection of myocardial and papillary muscle fibrosis, using either late gadolinium enhancement (at the basal segment of the inferolateral wall and papillary muscles) (macro-fibrosis), or diffuse fibrosis by T1 mapping (native and post contrast T1). Moreover, there are also preliminary data on positron emission tomography utilizing 18F-fluorodeoxyglucose as a tool for providing evidence of early myocardial inflammation. The objective of this review article is to provide the clinician with an overview and a practical clinical approach to MVP for risk stratification and treatment guidance.
Unraveling Bicuspid Aortic Valve Enigmas by Multimodality Imaging: Clinical Implications
Authors: Evangelista Masip Arturo , Galian-Gay Laura , Guala Andrea , Lopez-Sainz Angela , Teixido-Turà Gisela , Ruiz Muñoz Aroa , Valente Filipa , Gutierrez Laura , Fernandez-Galera Ruben , Casas Guillem , Panaro Alejandro , Marigliano Alba , Huguet Marina , González-Alujas Teresa , Rodriguez-Palomares Jose
Published: January 2022

Multimodality imaging is the basis of the diagnosis, follow-up, and surgical management of bicuspid aortic valve (BAV) patients. Transthoracic echocardiography (TTE) is used in our clinical routine practice as a first line imaging for BAV diagnosis, valvular phenotyping and function, measurement of thoracic aorta, exclusion of other aortic malformations, and for the assessment of complications such are infective endocarditis and aortic. Nevertheless, TTE is less useful if we want to assess accurately other aortic segments such as mid-distal ascending aorta, where computed tomography (CT) and magnetic resonance (CMR) could improve the precision of aorta size measurement by multiplanar reconstructions. A major advantage of CT is its superior spatial resolution, which affords a better definition of valve morphology and calcification, accuracy, and reproducibility of ascending aorta size, and allows for coronary artery assessment. Moreover, CMR offers the opportunity of being able to evaluate aortic functional properties and blood flow patterns. In this setting, new developed sequences such as 4D-flow may provide new parameters to predict events during follow up. The integration of all multimodality information facilitates a comprehensive evaluation of morphologic and dynamic features, stratification of the risk, and therapy guidance of this cohort of patients.
Hemodynamic Evaluation of the Right Heart-Pulmonary Circulation Unit in Patients Candidate to Transjugular Intrahepatic Portosystemic Shunt
Authors: Manguso Giulia , Vignone Anthony , Merli Manuela , Miotti Cristiano , Caputo Annalisa , Vizza Carmine Dario , Badagliacca Roberto
Published: January 2022

In Europe, liver cirrhosis represents the fourth-most common cause of death, being responsible for 170,000 deaths and 5500 liver transplantations per year. The main driver of its decompensation is portal hypertension, whose progression radically changes the prognosis of affected patients. Transjugular intrahepatic portosystemic shunt (TIPS) is one of the main therapeutic strategies for these patients as it reverts portal hypertension, thus improving survival. However, the coexistence of portal hypertension and pulmonary hypertension or heart failure is considered a contraindication to TIPS. Nevertheless, in the latest guidelines, the definition of heart failure has not been specified. It is unclear whether the contraindication concerns the presence of clinical signs and symptoms of heart failure or hemodynamic changes in the right heart-pulmonary circulation. Moreover, data about induced right heart volume overload after TIPS and the potential development of heart failure and pulmonary hypertension is currently scanty and controversial. In this article we revise this issue in finding predictors of cardiac performance after TIPS procedure. Performing a fluid challenge during right heart catheterization might be a promising expedient to test the adaptation of the right ventricle to a sudden increase in preload in the first few months after TIPS. This test may unmask a potential cardiac inability to sustain the hemodynamic load after TIPS, allowing for a clearer definition of heart failure and, consequently, a more robust indication to TIPS.
Principles for an Implementation of a Complete CT Reconstruction Tool Chain for Arbitrary Sized Data Sets and Its GPU Optimization
Authors: Hofmann Jürgen , Flisch Alexander , Zboray Robert
Published: January 2022

This article describes the implementation of an efficient and fast in-house computed tomography (CT) reconstruction framework. The implementation principles of this cone-beam CT reconstruction tool chain are described here. The article mainly covers the core part of CT reconstruction, the filtered backprojection and its speed up on GPU hardware. Methods and implementations of tools for artifact reduction such as ring artifacts, beam hardening, algorithms for the center of rotation determination and tilted rotation axis correction are presented. The framework allows the reconstruction of CT images of arbitrary data size. Strategies on data splitting and GPU kernel optimization techniques applied for the backprojection process are illustrated by a few examples.
Control of Reactive Oxygen Species through Antioxidant Enzymes Plays a Pivotal Role during the Cultivation of Neopyropia yezoensis
Authors: Feng Zezhong , Wu Lingjuan , Sun Zhenjie , Yang Jiali , Liu Guiyan , Niu Jianfeng , Wang Guangce
Published: January 2022

Neopyropia yezoensis is an economically important marine crop that can survive dehydrating conditions when nets are lifted from seawater. During this process, production of oxygen radicals and the resulting up-regulation of antioxidant enzymes mediated by the abscisic acid (ABA) signaling pathway played an important role. However, there were no reports about the significance regarding the protection of seaweed throughout the entire production season. Especially, in new aquatic farms in Shandong Province that were formed when traditional N. yezoensis cultivation moved north. Here, we determined the levels of ABA, hydrogen peroxide (H2O2), soluble protein, chlorophyll, and cell wall polysaccharides in samples collected at different harvest periods from Jimo aquatic farm, Shandong Province. The activities and expression of NADPH oxidase (NOX) and antioxidant enzymes in the corresponding samples were also determined. Combined with the monitoring data of sea surface temperature and solar light intensity, we proposed that the cultivation of N. yezoensis in Shandong Province was not affected by high-temperature stress. However, photoinhibition in N. yezoensis usually occurs at noon, especially in March. Both the activities and the expression of NOX and antioxidant enzymes were up-regulated continuously. It is reasonable to speculate that the reactive oxygen species (ROS) produced by NOX induced the up-regulation of antioxidant enzymes through the ABA signaling pathway. Although antioxidant enzymes play a pivotal role during the cultivation of N. yezoensis, the production of ROS also caused a shift in gene expression, accumulation of secondary metabolites, and even decreased the chlorophyll pool size, which eventually led to a decrease in algae assimilation. Accordingly, we suggest that the dehydration of N. yezoensis nets should be adopted when necessary and the extent of dehydration should be paid special consideration to avoid an excessive cellular response caused by ROS.
The CfMK1 Gene Regulates Reproduction, Appressorium Formation, and Pathogenesis in a Pear Anthracnose-Causing Fungus
Authors: Li Chaohui , Sun Weibo , Cao Shulin , Hou Rongxian , Li Xiaogang , Ming Liang , Kan Jialiang , Zhao Yancun , Liu Fengquan
Published: January 2022

Colletotrichum fructicola, the causal agent of pear anthracnose, causes significant annual economic losses. Mitogen-activated protein kinase (MAPK) cascades are highly conserved signal transduction pathways that play a crucial role in mediating cellular responses to environmental and host signals in plant pathogenic fungi. In this study, we identified an ortholog of the FUS3/KSS1-related MAPK gene, CfMK1, and characterized its function in C. fructicola. The Cfmk1 deletion mutants exhibited poorly developed aerial hyphae, autolysis, no conidial mass or perithecia on solid plates. However, the conidiation of the Cfmk1 mutant in PDB liquid medium was normal compared with that of the wild type (WT). Conidia of the Cfmk1 mutant exhibited a reduced germination rate on glass slides or plant surfaces. The Cfmk1 deletion mutants were unable to form appressoria and lost the capacity to penetrate plant epidermal cells. The ability of the Cfmk1 mutants to infect pear leaves and fruit was severely reduced. Moreover, RNA sequencing (RNA-seq) analysis of the WT and Cfmk1 mutant was performed, and the results revealed 1886 upregulated and 1554 downregulated differentially expressed genes (DEGs) in the mutant. The DEGs were significantly enriched in cell wall and pathogenesis terms, which was consistent with the defects of the Cfmk1 mutant in cell wall integrity and plant infection. Overall, our data demonstrate that CfMK1 plays critical roles in the regulation of aerial hyphal growth, asexual and sexual reproduction, autolysis, appressorium formation, and pathogenicity.
Saccharomyces cerevisiae Cells Lacking the Zinc Vacuolar Transporter Zrt3 Display Improved Ethanol Productivity in Lignocellulosic Hydrolysates
Authors: Terra-Matos Joana , Teixeira Marta Oliveira , Santos-Pereira Cátia , Noronha Henrique , Domingues Lucília , Sieiro Carmen , Gerós Hernâni , Chaves Susana Rodrigues , Sousa Maria João , Côrte-Real Manuela
Published: January 2022

Yeast-based bioethanol production from lignocellulosic hydrolysates (LH) is an attractive and sustainable alternative for biofuel production. However, the presence of acetic acid (AA) in LH is still a major problem. Indeed, above certain concentrations, AA inhibits yeast fermentation and triggers a regulated cell death (RCD) process mediated by the mitochondria and vacuole. Understanding the mechanisms involved in AA-induced RCD (AA-RCD) may thus help select robust fermentative yeast strains, providing novel insights to improve lignocellulosic ethanol (LE) production. Herein, we hypothesized that zinc vacuolar transporters are involved in vacuole-mediated AA-RCD, since zinc enhances ethanol production and zinc-dependent catalase and superoxide dismutase protect from AA-RCD. In this work, zinc limitation sensitized wild-type cells to AA-RCD, while zinc supplementation resulted in a small protective effect. Cells lacking the vacuolar zinc transporter Zrt3 were highly resistant to AA-RCD, exhibiting reduced vacuolar dysfunction. Moreover, zrt3Δ cells displayed higher ethanol productivity than their wild-type counterparts, both when cultivated in rich medium with AA (0.29 g L−1 h−1 versus 0.11 g L−1 h−1) and in an LH (0.73 g L−1 h−1 versus 0.55 g L−1 h−1). Overall, the deletion of ZRT3 emerges as a promising strategy to increase strain robustness in LE industrial production.
In Vitro Assessment of Organic and Residual Fractions of Nematicidal Culture Filtrates from Thirteen Tropical Trichoderma Strains and Metabolic Profiles of Most-Active
Authors: Moo-Koh Felicia Amalia , Cristóbal-Alejo Jairo , Andrés María Fé , Martín Jesús , Reyes Fernando , Tun-Suárez Jose María , Gamboa-Angulo Marcela
Published: January 2022

The nematicidal properties of Trichoderma species have potential for developing safer biocontrol agents. In the present study, 13 native Trichoderma strains from T. citrinoviride, T. ghanense (2 strains), T. harzianum (4), T. koningiopsis, T. simmonsii, and T. virens (4) with nematicidal activity were selected and cultured in potato dextrose broth to obtain a culture filtrate (CF) for each. Each CF was partitioned with ethyl acetate to obtain organic (EA) and residual filtrate (RF) fractions, which were then tested on second-stage juveniles (J2s) of the nematodes Meloidogyne javanica and M. incognita in a microdilution assay. The most lethal strains were T. harzianum Th43-14, T. koningiopsis Th41-11, T. ghanense Th02-04, and T. virens Th32-09, which caused 51–100% mortality (%M) of J2s of both nematodes, mainly due to their RF fractions. Liquid chromatography–diode array detector-electrospray-high resolution mass spectrometry analysis of the most-active fractions revealed sesquiterpene and polyketide-like metabolites produced by the four active strains. These native Trichoderma strains have a high potential to develop safer natural products for the biocontrol of Meloidogyne species.
Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity
Authors: Martins-Gomes Carlos , Silva Tânia L. , Andreani Tatiana , Silva Amélia M.
Published: January 2022

Glyphosate-based herbicide has been the first choice for weed management worldwide since the 1970s, mainly due to its efficacy and reported low toxicity, which contributed to its high acceptance. Many of the recent studies focus solely on the persistence of pesticides in soils, air, water or food products, or even on the degree of exposure of animals, since their potential hazards to human health have raised concerns. Given the unaware exposure of the general population to pesticides, and the absence of a significant number of studies on occupational hazards, new glyphosate-induced toxicity data obtained for both residual and acute doses should be analyzed and systematized. Additionally, recent studies also highlight the persistence and toxicity of both glyphosate metabolites and surfactants present in herbicide formulations. To renew or ban the use of glyphosate, recently published studies must be taken into account, aiming to define new levels of safety for exposure to herbicide, its metabolites, and the toxic excipients of its formulations. This review aims to provide an overview of recent publications (2010–present) on in vitro and in vivo studies aimed at verifying the animal toxicity induced by glyphosate, its metabolite aminomethylphosphonic acid (AMPA) and glyphosate-based formulations, evaluated in various experimental models. Apart from glyphosate-induced toxicity, recent data concerning the role of surfactants in the toxicity of glyphosate-based formulations are discussed.
Identification of Survival-Specific Genes in Clear Cell Renal Cell Carcinoma Using a Customized Next-Generation Sequencing Gene Panel
Authors: Hwang Jia , Kim Heeeun , Han Jinseon , Lee Jieun , Hong Sunghoo , Kim Saewoong , Yoon Sungjoo Kim , Choi Keonwoo , Yang Jihoon , Park Unsang , Kim Kwangjoong , Yim Kwangil , Kim Yuil , Choi Yeongjin
Published: January 2022

Purpose: Although mutations are associated with carcinogenesis, little is known about survival-specific genes in clear cell renal cell carcinoma (ccRCC). We developed a customized next-generation sequencing (NGS) gene panel with 156 genes. The purpose of this study was to investigate whether the survival-specific genes we found were present in Korean ccRCC patients, and their association with clinicopathological findings. Materials and Methods: DNA was extracted from the formalin-fixed, paraffin-embedded tissue of 22 ccRCC patients. NGS was performed using our survival-specific gene panel with an Illumina MiSeq. We analyzed NGS data and the correlations between mutations and clinicopathological findings and also compared them with data from the Cancer Genome Atlas-Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) and Renal Cell Cancer-European Union (RECA-EU). Results: We found a total of 100 mutations in 37 of the 156 genes (23.7%) in 22 ccRCC patients. Of the 37 mutated genes, 11 were identified as clinicopathologically significant. Six were novel survival-specific genes (ADAMTS10, CARD6, NLRP2, OBSCN, SECISBP2L, and USP40), and five were top-ranked mutated genes (AKAP9, ARID1A, BAP1, KDM5C, and SETD2). Only CARD6 was validated as an overall survival-specific gene in this Korean study (p = 0.04, r = −0.441), TCGA-KIRC cohort (p = 0.0003), RECA-EU (p = 0.0005). The 10 remaining gene mutations were associated with clinicopathological findings; disease-free survival, mortality, nuclear grade, sarcomatoid component, N-stage, sex, and tumor size. Conclusions: We discovered 11 survival-specific genes in ccRCC using data from TCGA-KIRC, RECA-EU, and Korean patients. We are the first to find a correlation between CARD6 and overall survival in ccRCC. The 11 genes, including CARD6, NLRP2, OBSCN, and USP40, could be useful diagnostic, prognostic, and therapeutic markers in ccRCC.
Clinical, Genetic and Functional Characterization of a Novel AVPR2 Missense Mutation in a Woman with X-Linked Recessive Nephrogenic Diabetes Insipidus
Authors: Selvaraj Senthil , Rodrigues Dírcea , Krishnamoorthy Navaneethakrishnan , Fakhro Khalid A. , Saraiva Luís R. , Lemos Manuel C.
Published: January 2022

Nephrogenic diabetes insipidus (NDI) is a rare disorder characterized by renal unresponsiveness to the hormone vasopressin, leading to excretion of large volumes of diluted urine. Mutations in the arginine vasopressin receptor-2 (AVPR2) gene cause congenital NDI and have an X-linked recessive inheritance. The disorder affects almost exclusively male family members, but female carriers occasionally present partial phenotypes due to skewed inactivation of the X-chromosome. Here, we report a rare case of a woman affected with X-linked recessive NDI, presenting an average urinary output of 12 L/day. Clinical and biochemical studies showed incomplete responses to water deprivation and vasopressin stimulation tests. Genetic analyses revealed a novel heterozygous missense mutation (c.493G > C, p.Ala165Pro) in the AVPR2 gene. Using a combination of in-silico protein modeling with human cellular models and molecular phenotyping, we provide functional evidence for phenotypic effects. The mutation destabilizes the helical structure of the AVPR2 transmembrane domains and disrupts its plasma membrane localization and downstream intracellular signaling pathways upon activation with its agonist vasopressin. These defects lead to deficient aquaporin 2 (AQP2) membrane translocation, explaining the inability to concentrate urine in this patient.
Perceived Causes and Solutions to Soil Degradation in the UK and Norway
Authors: Rust Niki , Lunder Ole Erik , Iversen Sara , Vella Steven , Oughton Elizabeth A. , Breland Tor Arvid , Glass Jayne H. , Maynard Carly M. , McMorran Rob , Reed Mark S.
Published: January 2022

Soil quality is declining in many parts of the world, with implications for the productivity, resilience and sustainability of agri-food systems. Research suggests multiple causes of soil degradation with no single solution and a divided stakeholder opinion on how to manage this problem. However, creating socially acceptable and effective policies to halt soil degradation requires engagement with a diverse range of stakeholders who possess different and complementary knowledge, experiences and perspectives. To understand how British and Norwegian agricultural stakeholders perceived the causes of and solutions to soil degradation, we used Q-methodology with 114 respondents, including farmers, scientists and agricultural advisers. For the UK, respondents thought the causes were due to loss of soil structure, soil erosion, compaction and loss of organic matter; the perceived solutions were to develop more collaborative research between researchers and farmers, invest in training, improve trust between farmers and regulatory agencies, and reduce soil compaction. In Norway, respondents thought soils were degrading due to soil erosion, monocultures and loss of soil structure; they believed the solutions were to reduce compaction, increase rotation and invest in agricultural training. There was an overarching theme related to industrialised agriculture being responsible for declining soil quality in both countries. We highlight potential areas for land use policy development in Norway and the UK, including multi-actor approaches that may improve the social acceptance of these policies. This study also illustrates how Q-methodology may be used to co-produce stakeholder-driven policy options to address land degradation.
2,2′-(Ethane-1,2-diyl)bis(4-chlorophenol)
Authors: Aitken R. Alan , Gidlow Anna L. G. , Ramsewak Russel S. , Slawin Alexandra M. Z.
Published: January 2022

The X-ray structure of the title compound, obtained as a byproduct in a natural product synthesis, has been determined and shows an unusual pattern featuring chains of molecules with both intra- and intermolecular hydrogen bonding of the OH groups.
A Study on the Electromagnetic–Thermal Coupling Effect of Cross-Slot Frequency Selective Surface
Authors: Lu Yi , Chen Juan , Li Jianxing , Xu Wenjing
Published: January 2022

In high-power microwave applications, the electromagnetic-thermal effect of frequency selective surface (FSS) cannot be ignored. In this paper, the electromagnetic-thermal coupling effects of cross-slot FSS were studied. We used an equivalent circuit method and CST software to analyze the electromagnetic characteristics of cross-slot FSS. Then, we used multi-field simulation software COMSOL Multiphysics to study the thermal effect of the FSSs. To verify the simulation results, we used a horn antenna with a power of 20 W to radiate the FSSs and obtain the stable temperature distribution of the FSSs. By using simulations and experiments, it is found that the maximum temperature of the cross-slot FSS appears in the middle of the cross slot. It is also found that the FSS with a narrow slot has severer thermal effect than that with a wide slot. In addition, the effects of different incident angles on the temperature variation of FSS under TE and TM polarization were also studied. It is found that in TE polarization, with the increase in incident angle, the maximum stable temperature of FSS increases gradually. In TM polarization, with the increase in incident angle, the maximum stable temperature of FSS decreases gradually.
Semi-Infinite Structure Analysis with Bimodular Materials with Infinite Element
Authors: Huang Wang , Yang Jianjun , Sladek Jan , Sladek Vladimir , Wen Pihua
Published: January 2022

The modulus of elasticity of some materials changes under tensile and compressive states is simulated by constructing a typical material nonlinearity in a numerical analysis in this paper. The meshless Finite Block Method (FBM) has been developed to deal with 3D semi-infinite structures in the bimodular materials in this paper. The Lagrange polynomial interpolation is utilized to construct the meshless shape function with the mapping technique to transform the irregular finite domain or semi-infinite physical solids into a normalized domain. A shear modulus strategy is developed to present the nonlinear characteristics of bimodular material. In order to verify the efficiency and accuracy of FBM, the numerical results are compared with both analytical and numerical solutions provided by Finite Element Method (FEM) in four examples.
Improvement of La0.8Sr0.2MnO3−δ Cathode Material for Solid Oxide Fuel Cells by Addition of YFe0.5Co0.5O3
Authors: Mosiałek Michał , Zimowska Małgorzata , Kharytonau Dzmitry , Komenda Anna , Górski Miłosz , Krzan Marcel
Published: January 2022

The high efficiency of solid oxide fuel cells with La0.8Sr0.2MnO3−δ (LSM) cathodes working in the range of 800–1000 °C, rapidly decreases below 800 °C. The goal of this study is to improve the properties of LSM cathodes working in the range of 500–800 °C by the addition of YFe0.5Co0.5O3 (YFC). Monophasic YFC is synthesized and sintered at 950 °C. Composite cathodes are prepared on Ce0.8Sm0.2O1.9 electrolyte disks using pastes containing YFC and LSM powders mixed in 0:1, 1:19, and 1:1 weight ratios denoted LSM, LSM1, and LSM1, respectively. X-ray diffraction patterns of tested composites reveal the presence of pure perovskite phases in samples sintered at 950 °C and the presence of Sr4Fe4O11, YMnO3, and La0.775Sr0.225MnO3.047 phases in samples sintered at 1100 °C. Electrochemical impedance spectroscopy reveals that polarization resistance increases from LSM1, by LSM, to LSM2. Differences in polarization resistance increase with decreasing operating temperatures because activation energy rises in the same order and equals to 1.33, 1.34, and 1.58 eV for LSM1, LSM, and LSM2, respectively. The lower polarization resistance of LSM1 electrodes is caused by the lower resistance associated with the charge transfer process.
Methodology for Neural Network-Based Material Card Calibration Using LS-DYNA MAT_187_SAMP-1 Considering Failure with GISSMO
Authors: Meißner Paul , Winter Jens , Vietor Thomas
Published: January 2022

A neural network (NN)-based method is presented in this paper which allows the identification of parameters for material cards used in Finite Element simulations. Contrary to the conventionally used computationally intensive material parameter identification (MPI) by numerical optimization with internal or commercial software, a machine learning (ML)-based method is time saving when used repeatedly. Within this article, a self-developed ML-based Python framework is presented, which offers advantages, especially in the development of structural components in early development phases. In this procedure, different machine learning methods are used and adapted to the specific MPI problem considered herein. Using the developed NN-based and the common optimization-based method with LS-OPT, the material parameters of the LS-DYNA material card MAT_187_SAMP-1 and the failure model GISSMO were exemplarily calibrated for a virtually generated test dataset. Parameters for the description of elasticity, plasticity, tension–compression asymmetry, variable plastic Poisson’s ratio (VPPR), strain rate dependency and failure were taken into account. The focus of this paper is on performing a comparative study of the two different MPI methods with varying settings (algorithms, hyperparameters, etc.). Furthermore, the applicability of the NN-based procedure for the specific usage of both material cards was investigated. The studies reveal the general applicability for the calibration of a complex material card by the example of the used MAT_187_SAMP-1.
Magneto-Mechanical Enhancement of Elastic Moduli in Magnetoactive Elastomers with Anisotropic Microstructures
Authors: Chougale Sanket , Romeis Dirk , Saphiannikova Marina
Published: January 2022

Magnetoactive elastomers (MAEs) have gained significant attention in recent years due to their wide range of engineering applications. This paper investigates the important interplay between the particle microstructure and the sample shape of MAEs. A simple analytical expression is derived based on geometrical arguments to describe the particle distribution inside MAEs. In particular, smeared microstructures are considered instead of a discrete particle distribution. As a consequence of considering structured particle arrangements, the elastic free energy is anisotropic. It is formulated with the help of the rule of mixtures. We show that the enhancement of elastic moduli arises not only from the induced dipole–dipole interactions in the presence of an external magnetic field but also considerably from the change in the particle microstructure.
Self-Healing of SiC-Al2O3-B4C Ceramic Composites at Low Temperatures
Authors: Wang Baoguo , Tu Rong , Wei Yinglong , Cai Haopeng
Published: January 2022

Self-healing ceramics have been researched at high temperatures, but few have been considered at lower temperatures. In this study, SiC-Al2O3-B4C ceramic composite was compacted by spark plasma sintering (SPS). A Vickers indentation was introduced, and the cracks were healed between 600 °C and 800 °C in air. Cracks could be healed completely in air above 700 °C. The ceramic composite had the best healing performance at 700 °C for 30 min, recovering flexural strength of up to 94.2% of the original. Good crack-healing ability would make this composite highly useful as it could heal defects and flaws autonomously in practical applications. The healing mechanism was also proposed to be the result of the oxidation of B4C.
New BODIPY Dyes Based on Benzoxazole as Photosensitizers in Radical Polymerization of Acrylate Monomers
Authors: Skotnicka Agnieszka , Kabatc Janina
Published: January 2022

A series of 2-phenacylbenzoxazole difluoroboranes named BODIPY dyes (1–8) was designed and applied as photosensitizers (PS) for radical photopolymerization of acrylate monomer. The light absorption within the ultraviolet-visible (UV–Vis) range (λmax = 350–410 nm; εmax = 23,000–42,500 M−1cm−1), that is strongly influenced by the substituents on the C3 and C4 atoms of phenyl ring, matched the emission of the Omnicure S2000 light within 320–500 nm. The photosensitizer possess fluorescence quantum yield from about 0.005 to 0.99. The 2-phenacylbenzoxazole difluoroboranes, together with borate salt (Bor), iodonium salt (Iod) or pyridinium salt (Pyr) acting as co-initiators, can generate active radicals upon the irradiation with a High Pressure Mercury Lamp which initiates a high-performance UV–Vis light-induced radical polymerization at 320–500 nm. The polymers obtained are characterized by strong photoluminescence. It was found that the type of radical generator (co-initiator) has a significant effect on the kinetic of radical polymerization of acrylate monomer. Moreover, the chemical structure of the BODIPY dyes does not influence the photoinitiating ability of the photoinitiator. The concentration of the photoinitiating system affects the photoinitiating performance. These 2-phenacylbenzoxazole difluoroborane-based photoinitiating systems have promising applications in UV–Vis-light induced polymerization.
Design and Optimization of High-Pressure Water Jet for Coal Breaking and Punching Nozzle Considering Structural Parameter Interaction
Authors: Chen Lihuan , Cheng Muzheng , Cai Yi , Guo Liwen , Gao Dianrong
Published: January 2022

The technology of increasing coal seam permeability by high-pressure water jet has significant advantages in preventing and controlling gas disasters in low-permeability coal seam. The structural parameters of a nozzle are the key to its jet performance. The majority of the current studies take strike velocity as the evaluation index, and the influence of the interaction between the nozzle’s structural parameters on its jet performance is not fully considered. In practice, strike velocity and strike area will affect gas release in the process of coal breaking and punching. To further optimize the structural parameters of coal breaking and punching nozzle, and improve water jet performance, some crucial parameters such as the contraction angle, outlet divergence angle, and length-to-diameter ratio are selected. Meanwhile, the maximum X-axis velocity and effective Y-axis extension distance are used as evaluation indexes. The effect of each key factor on the water jet performance is analyzed by numerical simulation using the single factor method. The significance and importance effect of each factor and their interaction on the water jet performance are quantitatively analyzed using the orthogonal experiment method. Moreover, three optimal combinations are selected for experimental verification. Results show that with an increase in contraction angle, outlet divergence angle, and length-to-diameter ratio, the maximum X-axis velocity increases initially and decreases thereafter. The Y-direction expansion distance of the jet will be improved significantly with an increase in the outlet divergence angle. Through field experiments, the jet performance of the improved nozzle 3 is the best. After optimization, the coal breaking and punching diameter of the nozzle is increased by 118%, and the punching depth is increased by 17.46%.
A Relaxed and Bound Algorithm Based on Auxiliary Variables for Quadratically Constrained Quadratic Programming Problem
Authors: Hu Chenyang , Gao Yuelin , Tian Fuping , Ma Suxia
Published: January 2022

Quadratically constrained quadratic programs (QCQP), which often appear in engineering practice and management science, and other fields, are investigated in this paper. By introducing appropriate auxiliary variables, QCQP can be transformed into its equivalent problem (EP) with non-linear equality constraints. After these equality constraints are relaxed, a series of linear relaxation subproblems with auxiliary variables and bound constraints are generated, which can determine the effective lower bound of the global optimal value of QCQP. To enhance the compactness of sub-rectangles and improve the ability to remove sub-rectangles, two rectangle-reduction strategies are employed. Besides, two ϵ-subproblem deletion rules are introduced to improve the convergence speed of the algorithm. Therefore, a relaxation and bound algorithm based on auxiliary variables are proposed to solve QCQP. Numerical experiments show that this algorithm is effective and feasible.
Individual Disturbance and Attraction Repulsion Strategy Enhanced Seagull Optimization for Engineering Design
Authors: Yu Helong , Qiao Shimeng , Heidari Ali Asghar , Bi Chunguang , Chen Huiling
Published: January 2022

The seagull optimization algorithm (SOA) is a novel swarm intelligence algorithm proposed in recent years. The algorithm has some defects in the search process. To overcome the problem of poor convergence accuracy and easy to fall into local optimality of seagull optimization algorithm, this paper proposed a new variant SOA based on individual disturbance (ID) and attraction-repulsion (AR) strategy, called IDARSOA, which employed ID to enhance the ability to jump out of local optimum and adopted AR to increase the diversity of population and make the exploration of solution space more efficient. The effectiveness of the IDARSOA has been verified using representative comprehensive benchmark functions and six practical engineering optimization problems. The experimental results show that the proposed IDARSOA has the advantages of better convergence accuracy and a strong optimization ability than the original SOA.
A Novel Bidirectional AlGaN/GaN ESD Protection Diode
Authors: Yao Bin , Shi Yijun , Wang Hongyue , Xu Xinbin , Chen Yiqiang , He Zhiyuan , Xiao Qingzhong , Wang Lei , Lu Guoguang , Li Hao , Huang Yun , Zhang Bo
Published: January 2022

Despite the superior working properties, GaN-based HEMTs and systems are still confronted with the threat of a transient ESD event, especially for the vulnerable gate structure of the p-GaN or MOS HEMTs. Therefore, there is still an urgent need for a bidirectional ESD protection diode to improve the ESD robustness of a GaN power system. In this study, an AlGaN/GaN ESD protection diode with bidirectional clamp capability was proposed and investigated. Through the combination of two floating gate electrodes and two pF-grade capacitors connected in parallel between anode or cathode electrodes and the adjacent floating gate electrodes (CGA (CGC)), the proposed diode could be triggered by a required voltage and possesses a high secondary breakdown current (IS) in both forward and reverse transient ESD events. Based on the experimental verification, it was found that the bidirectional triggering voltages (Vtrig) and IS of the proposed diode were strongly related to CGA (CGC). With CGA (CGC) increasing from 5 pF to 25 pF, Vtrig and IS decreased from ~18 V to ~7 V and from ~7 A to ~3 A, respectively. The diode’s high performance demonstrated a good reference for the ESD design of a GaN power system.
A Review on Manufacturing and Post-Processing Technology of Vascular Stents
Authors: Jiang Wei , Zhao Wenxiang , Zhou Tianfeng , Wang Liang , Qiu Tianyang
Published: January 2022

Percutaneous coronary intervention (PCI) with stent implantation is one of the most effective treatments for cardiovascular diseases (CVDs). However, there are still many complications after stent implantation. As a medical device with a complex structure and small size, the manufacture and post-processing technology greatly impact the mechanical and medical performances of stents. In this paper, the development history, material, manufacturing method, and post-processing technology of vascular stents are introduced. In particular, this paper focuses on the existing manufacturing technology and post-processing technology of vascular stents and the impact of these technologies on stent performance is described and discussed. Moreover, the future development of vascular stent manufacturing technology will be prospected and proposed.
Antiviral Property of the Fungal Metabolite 3-O-Methylfunicone in Bovine Herpesvirus 1 Infection
Authors: Fiorito Filomena , Cerracchio Claudia , Salvatore Maria Michela , Serra Francesco , Pucciarelli Alessia , Amoroso Maria Grazia , Nicoletti Rosario , Andolfi Anna
Published: January 2022

Bovine herpesvirus type-1 (BoHV-1) is a widespread pathogen that provokes infectious rhinotracheitis and polymicrobial infections in cattle, resulting in serious economic losses to the farm animal industry and trade restrictions. To date, non-toxic active drugs against BoHV-1 are not available. The exploitation of bioactive properties of microbial products is of great pharmaceutical interest. In fact, fungi are a promising source of novel drugs with a broad spectrum of activities and functions, including antiviral properties. Hence, the potential antiviral properties of 3-O-methylfunicone (OMF), a secondary metabolite produced by Talaromyces pinophilus, were evaluated on BoHV-1. In this study, during BoHV-1 infection in bovine cells (MDBK), the non-toxic concentration of 5 µM OMF considerably reduced signs of cell death and increased cell proliferation. Furthermore, OMF significantly decreased the virus titer as well as the cytopathic effect and strongly inhibited the expression of bICP0, the major regulatory protein in the BoHV-1 lytic cycle. These findings were accompanied by a considerable up-regulation in the expression of the aryl hydrocarbon receptor (AhR), a multifunctional transcription factor also linked to the host’s response to a herpesvirus infection. Overall, our results suggest that by involving AhR, OMF shows potential against a BoHV-1 infection.
Regulation of Tomato Specialised Metabolism after Establishment of Symbiosis with the Endophytic Fungus Serendipita indica
Authors: Ntana Fani , Johnson Sean R. , Hamberger Björn , Jensen Birgit , Jørgensen Hans J. L. , Collinge David B.
Published: January 2022

Specialised metabolites produced during plant-fungal associations often define how symbiosis between the plant and the fungus proceeds. They also play a role in the establishment of additional interactions between the symbionts and other organisms present in the niche. However, specialised metabolism and its products are sometimes overlooked when studying plant-microbe interactions. This limits our understanding of the specific symbiotic associations and potentially future perspectives of their application in agriculture. In this study, we used the interaction between the root endophyte Serendipita indica and tomato (Solanum lycopersicum) plants to explore how specialised metabolism of the host plant is regulated upon a mutualistic symbiotic association. To do so, tomato seedlings were inoculated with S. indica chlamydospores and subjected to RNAseq analysis. Gene expression of the main tomato specialised metabolism pathways was compared between roots and leaves of endophyte-colonised plants and tissues of endophyte-free plants. S. indica colonisation resulted in a strong transcriptional response in the leaves of colonised plants. Furthermore, the presence of the fungus in plant roots appears to induce expression of genes involved in the biosynthesis of lignin-derived compounds, polyacetylenes, and specific terpenes in both roots and leaves, whereas pathways producing glycoalkaloids and flavonoids were expressed in lower or basal levels.
Estimation of the Impact of Basement Heterogeneity on Thermal History Reconstruction: The Western Siberian Basin
Authors: Peshkov Georgy Alexandrovich , Chekhonin Evgeny Mikhailovich , Pissarenko Dimitri Vladilenovich
Published: January 2022

Some of the simplifying assumptions frequently used in basin modelling may adversely impact the quality of the constructed models. One such common assumption consists of using a laterally homogeneous crustal basement, despite the fact that lateral variations in its properties may significantly affect the thermal evolution of the model. We propose a new method for the express evaluation of the impact of the basement’s heterogeneity on thermal history reconstruction and on the assessment of maturity of the source rock. The proposed method is based on reduced-rank inversion, aimed at a simultaneous reconstruction of the petrophysical properties of the heterogeneous basement and of its geometry. The method uses structural information taken from geological maps of the basement and gravity anomaly data. We applied our method to a data collection from Western Siberia and carried out a two-dimensional reconstruction of the evolution of the basin and of the lithosphere. We performed a sensitivity analysis of the reconstructed basin model to assess the effect of uncertainties in the basement’s density and its thermal conductivity for the model’s predictions. The proposed method can be used as an express evaluation tool to assess the necessity and relevance of laterally heterogeneous parametrisations prior to a costly three-dimensional full-rank basin modelling. The method is generally applicable to extensional basins except for salt tectonic provinces.