bluuebunny/crossref_metadata_2025 huggingface dataset:
Stretchable and Robust Candle-Soot Nanoparticle-Polydimethylsiloxane Composite Films for Laser-Ultrasound Transmitters
Authors: Faraz Muhammad , Abbasi Muhammad Awais , Sang Pilgyu , Son Donghee , Baac Hyoung Won
Published: June 2020

Considerable attention has been devoted to the development of nanomaterial-based photoacoustic transmitters for ultrasound therapy and diagnosis applications. Here, we fabricate and characterize candle-soot nanoparticles (CSNPs) and polydimethylsiloxane (PDMS) composite-based photoacoustic transmitters, based on a solution process, not just to achieve high-frequency and high-amplitude pressure outputs, but also to develop physically stretchable ultrasound transmitters. Owing to its non-porous and non-agglomerative characteristics, the composite exhibits unique photo-thermal and mechanical properties. The output pressure amplitudes from CSNPs–PDMS composites were 20–26 dB stronger than those of Cr film, used as a reference. The proposed transmitters also offered a center frequency of 2.44–13.34 MHz and 6-dB bandwidths of 5.80–13.62 MHz. Importantly, we characterize the mechanical robustness of CSNPs–PDMS quantitatively, by measuring laser-damage thresholds, to evaluate the upper limit of laser energy that can be ultimately used as an input, i.e., proportional to the maximum-available pressure output. The transmitters could endure an input laser fluence of 54.3–108.6 mJ·cm−2. This is 1.65–3.30 times higher than the Cr film, and is significantly higher than the values of other CSNPs–PDMS transmitters reported elsewhere (22–81 mJ·cm−2). Moreover, we characterized the strain-dependent photoacoustic output of a stretchable nanocomposite film, obtained by delaminating it from the glass substrate. The transmitter could be elongated elastically up to a longitudinal strain of 0.59. Under this condition, it maintained a center frequency of 6.72–9.44 MHz, and 6-dB bandwidth ranges from 12.05 to 14.02 MHz. We believe that the stretchable CSNPs–PDMS composites would be useful in developing patch-type ultrasound devices conformally adhered on skin for diagnostic and therapeutic applications.
Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer’s Disease Progression
Authors: Protto Virginia , Tramutola Antonella , Fabiani Marco , Marcocci Maria Elena , Napoletani Giorgia , Iavarone Federica , Vincenzoni Federica , Castagnola Massimo , Perluigi Marzia , Di Domenico Fabio , De Chiara Giovanna , Palamara Anna Teresa
Published: June 2020

Compelling evidence supports the role of oxidative stress in Alzheimer’s disease (AD) pathophysiology. Interestingly, Herpes simplex virus-1 (HSV-1), a neurotropic virus that establishes a lifelong latent infection in the trigeminal ganglion followed by periodic reactivations, has been reportedly linked both to AD and to oxidative stress conditions. Herein, we analyzed, through biochemical and redox proteomic approaches, the mouse model of recurrent HSV-1 infection we previously set up, to investigate whether multiple virus reactivations induced oxidative stress in the mouse brain and affected protein function and related intracellular pathways. Following multiple HSV-1 reactivations, we found in mouse brains increased levels of oxidative stress hallmarks, including 4-hydroxynonenal (HNE), and 13 HNE-modified proteins whose levels were found significantly altered in the cortex of HSV-1-infected mice compared to controls. We focused on two proteins previously linked to AD pathogenesis, i.e., glucose-regulated protein 78 (GRP78) and collapsin response-mediated protein 2 (CRMP2), which are involved in the unfolded protein response (UPR) and in microtubule stabilization, respectively. We found that recurrent HSV-1 infection disables GRP78 function and activates the UPR, whereas it prevents CRMP2 function in mouse brains. Overall, these data suggest that repeated HSV-1 reactivation into the brain may contribute to neurodegeneration also through oxidative damage.
The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review
Authors: Gonzalez-Gil Adrian M. , Elizondo-Montemayor Leticia
Published: June 2020

Exercise is an effective strategy for preventing and treating obesity and its related cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue browning, redistribution of energy substrates, optimization of global energy expenditure, enhancement of hypothalamic circuits that control appetite-satiety and energy expenditure, and decreased systemic inflammation and insulin resistance. Novel exercise-inducible soluble factors, including myokines, hepatokines, and osteokines, and immune cytokines and adipokines are hypothesized to play an important role in the body’s response to exercise. To our knowledge, no review has provided a comprehensive integrative overview of these novel molecular players and the mechanisms involved in the redistribution of metabolic fuel during and after exercise, the loss of weight and fat mass, and reduced inflammation. In this review, we explain the potential role of these exercise-inducible factors, namely myokines, such as irisin, IL-6, IL-15, METRNL, BAIBA, and myostatin, and hepatokines, in particular selenoprotein P, fetuin A, FGF21, ANGPTL4, and follistatin. We also describe the function of osteokines, specifically osteocalcin, and of adipokines such as leptin, adiponectin, and resistin. We also emphasize an integrative overview of the pleiotropic mechanisms, the metabolic pathways, and the inter-organ crosstalk involved in energy expenditure, fat mass loss, reduced inflammation, and healthy weight induced by exercise.
Influence of Self-Efficacy and Motivation to Follow a Healthy Diet on Life Satisfaction of Patients with Cardiovascular Disease: A Longitudinal Study
Authors: Castillo-Mayén Rosario , Cano-Espejo Cristina , Luque Bárbara , Cuadrado Esther , Gutiérrez-Domingo Tamara , Arenas Alicia , Rubio Sebastián J. , Delgado-Lista Javier , Pérez-Martínez Pablo , Tabernero Carmen
Published: June 2020

Today, cardiovascular disease has a great impact on the global population due to its high prevalence. One challenge that cardiovascular patients face to achieve a better prognosis is to follow a healthy diet. This study focused on psychological factors linked to adaptation to a healthy diet in these patients. The main objective was to analyze the interrelationship between motivation to follow a healthy diet and self-efficacy to adhere to the Mediterranean diet with life satisfaction over time. The sample consisted of cardiovascular patients who were assessed at three measurement moments (NT1 = 755; NT2 = 593; NT3 = 323, average interval time: nine months). Correlation analyses showed that self-efficacy, motivation, and life satisfaction followed a pattern of positive relations across the three measurements. A time effect over the study variables was also observed. The results of path analyses showed that self-efficacy positively predicted autonomous motivation, which in turn was associated with patients’ life satisfaction. This interrelation was stable over a period of 18 months. Moreover, life satisfaction predicted self-efficacy nine months later. Psychological interventions might be a positive resource for cardiovascular patients, since psychological variables influence their life satisfaction and their subsequent quality of life in their new health condition.
Binding and Neutralizing Capacity of Respiratory Syncytial Virus (RSV)-Specific Recombinant IgG Against RSV in Human Milk, Gastric and Intestinal Fluids from Infants
Authors: Demers-Mathieu Veronique , Lueangsakulthai Jiraporn , Qu Yunyao , Scottoline Brian P. , Dallas David C.
Published: June 2020

Oral administration of pathogen-specific recombinant antibodies may help to prevent infant gastrointestinal (GI) pathogen infection; however, to neutralize an infectious agent, these antibodies must resist degradation in the GI tract. Palivizumab, a recombinant antibody specific for the respiratory syncytial virus (RSV), was used as a model for pathogen-specific IgG in human milk. The aim was to compare the remaining binding capacity of palivizumab in milk between three mothers after exposure to an in vitro model of infant gastrointestinal digestion (gastric and duodenal fluids) using ELISA. The neutralizing capacity of palivizumab in pooled human milk, gastric contents, and stools from preterm infants was also evaluated for blocking RSV with green fluorescent protein (RSV-GFP) infection in Hep-2 cells using confocal and inverted microscopy and flow cytometry. The reduction of palivizumab binding capacity in human milk and digested samples was slightly different between mothers. Overall, palivizumab decreased 50% after simulated gastric digestion with pepsin and 62% after simulated intestinal digestion with pancreatin. Palivizumab (2–8 μg/mL) in human milk or stool samples blocked RSV (3.4 × 104 FFU/mL) infection (no syncytia formation on Hep-2 cells) by microscopy. Syncytia formation was detected on Hep-2 cells when RSV was incubated in gastric contents or virus medium with 2–4 μg/mL of palivizumab, but no infection was observed at 8 μg/mL. No fluorescence (absence of infected cells) was detected when palivizumab (100 μg/mL) was incubated in human milk or medium with RSV-GFP (1.1 × 105 FFU/mL), whereas fluorescence increased with the reduced concentration of palivizumab using flow cytometry. These results suggest that undigested and digested matrices could change the binding and neutralizing capacity of viral pathogen-specific antibodies.
Nutritional and Clinical Factors Affecting Weight and Fat-Free Mass Loss after Gastrectomy in Patients with Gastric Cancer
Authors: Lim Hee-Sook , Lee Bora , Cho In , Cho Gyu Seok
Published: June 2020

After a gastrectomy, the nutritional status of patients with gastric cancer has great effect on the treatment outcome and patients’ quality of life. We investigated the changes in body composition and nutrient intake after gastrectomy in 288 gastric cancer patients. A multiple linear regression analysis was used for each time period to verify the effects of nutritional and clinical factors on weight and fat-free mass loss rates. Gastric cancer patients who underwent a gastrectomy continued to experience weight and fat-free mass loss until three months after surgery and became stagnant at six months. The marginal mean of calorie intake per weight was 24.5, 26.8, and 29.4 kcal at one, three, and six months. The protein intake per kg lean mass was 1.14, 1.14, and 1.16 g at one, three, and six months, respectively. One month after surgery, the rate of weight loss increased significantly in females who received chemotherapy (p < 0.001). At one to three months postoperative, females who had undergone chemotherapy tended to significantly lose weight (p = 0.016). Females with a history of chemotherapy also showed a reduction in fat-free mass for one to three months (p = 0.036). Calorie intake was a significant factor in preventing fat-free mass weight loss at one month after surgery. Chemotherapy was an independent factor affecting the weight and fat-free mass loss rate up to six months after gastrectomy. Careful monitoring of weight and muscle mass changes following active nutritional intervention for sufficient nutrition support could be helpful for patients after gastrectomy.
Dietary Patterns Are Associated with Risk of Prostate Cancer in a Population-Based Case-Control Study in Montreal, Canada
Authors: Trudeau Karine , Rousseau Marie-Claude , Barul Christine , Csizmadi Ilona , Parent Marie-Élise
Published: June 2020

This study describes the association between dietary patterns and prostate cancer (PCa) risk in a population-based case-control study conducted in Montreal, Canada (2005–2012). Cases (n = 1919) were histologically confirmed, aged ≤75 years. Concomitantly, controls (n = 1991) were randomly selected from the electoral list and frequency-matched to cases by age (±5 years). During face-to-face interviews, a 63-item food frequency questionnaire focusing on the two years before diagnosis/interview was administered. Three dietary patterns were identified from principal component analysis. Unconditional logistic regression estimated the association between dietary patterns and PCa, adjusting for age, ethnicity, education, family history, and timing of last PCa screening. When comparing scores in the highest vs. lowest quartiles, the Healthy Eating pattern was associated with a decreased risk of overall PCa (Odds ratio (OR) = 0.76, 95% confidence interval (CI) = 0.61, 0.93); this association was stronger for high-grade cancers (OR = 0.66, 95% CI = 0.48, 0.89). By contrast, the Western Sweet and Beverages pattern was associated with an elevated risk of overall PCa (OR = 1.35, 95% CI = 1.10, 1.66). The Western Salty and Alcohol pattern was not associated with PCa risk. These findings suggest that some dietary patterns influence PCa development.
Conjugated Linoleic Acid and Its Beneficial Effects in Obesity, Cardiovascular Disease, and Cancer
Authors: Basak Sanjay , Duttaroy Asim K.
Published: June 2020

Conjugated linoleic acid (CLA) is a dietary polyunsaturated fatty acid found in animal fats such as red meat and dairy products [...]
Usefulness of Carnitine Supplementation for the Complications of Liver Cirrhosis
Authors: Hanai Tatsunori , Shiraki Makoto , Imai Kenji , Suetugu Atsushi , Takai Koji , Shimizu Masahito
Published: June 2020

Carnitine is a vitamin-like substance that regulates lipid metabolism and energy production. Carnitine homeostasis is mainly regulated by dietary intake and biosynthesis in the organs, including the skeletal muscle and the liver. Therefore, liver cirrhotic patients with reduced food intake, malnutrition, biosynthetic disorder, and poor storage capacity of carnitine in the skeletal muscle and liver are more likely to experience carnitine deficiency. In particular, liver cirrhotic patients with sarcopenia are at a high risk for developing carnitine deficiency. Carnitine deficiency impairs the important metabolic processes of the liver, such as gluconeogenesis, fatty acid metabolism, albumin biosynthesis, and ammonia detoxification by the urea cycle, and causes hypoalbuminemia and hyperammonemia. Carnitine deficiency should be suspected in liver cirrhotic patients with severe malaise, hepatic encephalopathy, sarcopenia, muscle cramps, and so on. Importantly, the blood carnitine level does not always decrease in patients with liver cirrhosis, and it sometimes exceeds the normal level. Therefore, patients with liver cirrhosis should be treated as if they are in a state of relative carnitine deficiency at the liver, skeletal muscle, and mitochondrial levels, even if the blood carnitine level is not decreased. Recent clinical trials have revealed the effectiveness of carnitine supplementation for the complications of liver cirrhosis, such as hepatic encephalopathy, sarcopenia, and muscle cramps. In conclusion, carnitine deficiency is not always rare in liver cirrhosis, and it requires constant attention in the daily medical care of this disease. Carnitine supplementation might be an important strategy for improving the quality of life of patients with liver cirrhosis.
Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis
Authors: López-Moreno Ana , Suárez Antonio , Avanzi Camila , Monteoliva-Sánchez Mercedes , Aguilera Margarita
Published: June 2020

Obesity is a growing health threat worldwide. Administration of probiotics in obesity has also parallelly increased but without any protocolization. We conducted a systematic review exploring the administration pattern of probiotic strains and effective doses for obesity-related disorders according to their capacity of positively modulating key biomarkers and microbiota dysbiosis. Manuscripts targeting probiotic strains and doses administered for obesity-related disorders in clinical studies were sought. MEDLINE, Scopus, Web of Science, and Cochrane Library databases were searched using keywords during the last fifteen years up to April 2020. Two independent reviewers screened titles, abstracts, and then full-text papers against inclusion criteria according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. From 549 interventional reports identified, we filtered 171 eligible studies, from which 24 full-text assays were used for calculating intervention total doses (ITD) of specific species and strains administered. Nine of these reports were excluded in the second-step because no specific data on gut microbiota modulation was found. Six clinical trials (CT) and 9 animal clinical studies were retained for analysis of complete outcome prioritized (body mass index (BMI), adiposity parameters, glucose, and plasma lipid biomarkers, and gut hormones). Lactobacillus spp. administered were double compared to Bifidobacterium spp.; Lactobacillus as single or multispecies formulations whereas most Bifidobacteria only through multispecies supplementations. Differential factors were estimated from obese populations’ vs. obesity-induced animals: ITD ratio of 2 × 106 CFU and patterns of administrations of 11.3 weeks to 5.5 weeks, respectively. Estimation of overall probiotics impact from selected CT was performed through a random-effects model to pool effect sizes. Comparisons showed a positive association between the probiotics group vs. placebo on the reduction of BMI, total cholesterol, leptin, and adiponectin. Moreover, negative estimation appeared for glucose (FPG) and CRP. While clinical trials including data for positive modulatory microbiota capacities suggested that high doses of common single and multispecies of Lactobacillus and Bifidobacterium ameliorated key obesity-related parameters, the major limitation was the high variability between studies and lack of standardized protocols. Efforts in solving this problem and searching for next-generation probiotics for obesity-related diseases would highly improve the rational use of probiotics.
Correlation of Body Composition and Nutritional Status with Functional Recovery in Stroke Rehabilitation Patients
Authors: Irisawa Hiroshi , Mizushima Takashi
Published: June 2020

Previous studies have suggested that the nutritional status after stroke is independently associated with long-term outcomes and that sarcopenia delays poststroke rehabilitation and worsens the prognosis. However, many stroke patients have a deteriorated nutritional status and a decreased muscle mass in the acute phase. This prospective study included 179 patients who were admitted to the stroke rehabilitation unit. We performed bioelectrical impedance analysis and determined the Geriatric Nutritional Risk Index (GNRI) to assess muscle mass and the nutritional status on admission. Furthermore, we analyzed the activities of daily living using the Functional Independence Measure (FIM) at the time of admission and four weeks later. Furthermore, we evaluated the change in motor FIM items and examined the relationship with the data. Multiple regression analysis revealed that a high muscle rate (skeletal muscle mass/body weight) (odds ratio OR = 2.43), high phase angle (OR = 3.32), and high GNRI (OR = 2.57) were significantly associated with motor FIM items at four weeks in male and female patients. Muscle mass maintenance through nutritional management and early rehabilitation in the acute period of stroke is essential for functional recovery in stroke patients.
The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
Authors: Ikeda Takashi , Morotomi Nobuo , Kamono Arinori , Ishimoto Saki , Miyazawa Ryo , Kometani Shogo , Sako Rikitaro , Kaneko Naohisa , Iida Mamoru , Kawate Nobuyuki
Published: June 2020

The combination of exercise and nutritional intervention is widely used for stroke patients, as well as frail or sarcopenic older persons. As previously shown, supplemental branched chain amino acids (BCAAs) or protein to gain muscle mass has usually been given just after exercise. This study investigated the effect of the timing of supplemental BCAAs with exercise intervention on physical function in stroke patients. The participants were randomly assigned to two groups based on the timing of supplementation: breakfast (n = 23) and post-exercise (n = 23). The supplement in the breakfast group was provided at 08:00 with breakfast, and in the post-exercise group it was provided just after the exercise session in the afternoon at 14:00–18:00. In both groups, the exercise intervention was performed with two sessions a day for two months. The main effects were observed in body fat mass (p = 0.02, confidence interval (CI): 13.2–17.7), leg press strength (p = 0.04, CI: 94.5–124.5), and Berg balance scale (p = 0.03, CI: 41.6–52.6), but no interaction with intake timing was observed. Although the effect of the timing of supplementation on skeletal muscle mass was similar in both groups, BCAA intake with breakfast was effective for improving physical performance and decreasing body fat mass. The results suggest that a combination of BCAA intake with breakfast and an exercise program was effective for promoting rehabilitation of post-stroke patients.
NHANES 2011–2014 Reveals Cognition of US Older Adults may Benefit from Better Adaptation to the Mediterranean Diet
Authors: Taylor Matthew K. , Mahnken Jonathan D. , Sullivan Debra K.
Published: June 2020

Although the Mediterranean diet (MedD) has gained interest for potential Alzheimer’s disease (AD) prevention, it is unknown how well US older adults follow a MedD. We used two National Health and Nutrition Examination Survey (NHANES) cycles (2011–2014) to conduct our primary aim of reporting population estimates of MedD adherence among older adults (60+ years) in the US (n = 3068). The mean MedD adherence score for US older adults was 5.3 ± 2.1 (maximum possible = 18), indicating that older adults in the US do not adhere to a MedD. There were various differences in MedD scores across demographic characteristics. We also assessed the cross-sectional relationship between MedD adherence and cognitive performance using survey-weighted ordinary least squares regression and binary logistic regression models adjusted for 11 covariates. Compared to the lowest MedD adherence tertile, the highest tertile had a lower odds ratio of low cognitive performance on three of five cognitive measures (p < 0.05 for each). Sensitivity analyses within participants without subjective memory complaints over the past year revealed similar results on the same three cognitive measures. We conclude that MedD interventions are a departure from usual dietary intake of older adults in the US and are a reasonable approach for AD prevention trials.
Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease
Authors: Kalantar-Zadeh Kamyar , Joshi Shivam , Schlueter Rebecca , Cooke Joanne , Brown-Tortorici Amanda , Donnelly Meghan , Schulman Sherry , Lau Wei-Ling , Rhee Connie , Streja Elani , Tantisattamo Ekamol , Ferrey Antoney , Hanna Ramy , Chen Joline , Malik Shaista , Nguyen Danh , Crowley Susan , Kovesdy Csaba
Published: June 2020

Chronic kidney disease (CKD) affects >10% of the adult population. Each year, approximately 120,000 Americans develop end-stage kidney disease and initiate dialysis, which is costly and associated with functional impairments, worse health-related quality of life, and high early-mortality rates, exceeding 20% in the first year. Recent declarations by the World Kidney Day and the U.S. Government Executive Order seek to implement strategies that reduce the burden of kidney failure by slowing CKD progression and controlling uremia without dialysis. Pragmatic dietary interventions may have a role in improving CKD outcomes and preventing or delaying dialysis initiation. Evidence suggests that a patient-centered plant-dominant low-protein diet (PLADO) of 0.6–0.8 g/kg/day composed of >50% plant-based sources, administered by dietitians trained in non-dialysis CKD care, is promising and consistent with the precision nutrition. The scientific premise of the PLADO stems from the observations that high protein diets with high meat intake not only result in higher cardiovascular disease risk but also higher CKD incidence and faster CKD progression due to increased intraglomerular pressure and glomerular hyperfiltration. Meat intake increases production of nitrogenous end-products, worsens uremia, and may increase the risk of constipation with resulting hyperkalemia from the typical low fiber intake. A plant-dominant, fiber-rich, low-protein diet may lead to favorable alterations in the gut microbiome, which can modulate uremic toxin generation and slow CKD progression, along with reducing cardiovascular risk. PLADO is a heart-healthy, safe, flexible, and feasible diet that could be the centerpiece of a conservative and preservative CKD-management strategy that challenges the prevailing dialysis-centered paradigm.
Tick-Borne Encephalitis Virus: Seasonal and Annual Variation of Epidemiological Parameters Related to Nymph-to-Larva Transmission and Exposure of Small Mammals
Authors: Bournez Laure , Umhang Gerald , Moinet Marie , Richomme Céline , Demerson Jean-Michel , Caillot Christophe , Devillers Elodie , Boucher Jean-Marc , Hansmann Yves , Boué Franck , Moutailler Sara
Published: June 2020

A greater knowledge of the ecology of the natural foci of tick-borne encephalitis virus (TBEV) is essential to better assess the temporal variations of the risk of tick-borne encephalitis for humans. To describe the seasonal and inter-annual variations of the TBEV-cycle and the epidemiological parameters related to TBEV nymph-to-larva transmission, exposure of small mammals to TBEV, and tick aggregation on small mammals, a longitudinal survey in ticks and small mammals was conducted over a 3-year period in a mountain forest in Alsace, eastern France. TBEV prevalence in questing nymphs was lower in 2013 than in 2012 and 2014, probably because small mammals (Myodes glareolus and Apodemus flavicollis) were more abundant in 2012, which reduced tick aggregation and co-feeding transmission between ticks. The prevalence of TBEV in questing nymphs was higher in autumn than spring. Despite these variations in prevalence, the density of infected questing nymphs was constant over time, leading to a constant risk for humans. The seroprevalence of small mammals was also constant over time, although the proportion of rodents infested with ticks varied between years and seasons. Our results draw attention to the importance of considering the complex relationship between small mammal densities, tick aggregation on small mammals, density of infected questing nymphs, and prevalence of infected nymphs in order to forecast the risk of TBEV for humans.
Photoprotective Effects of Selected Amino Acids on Naproxen Photodegradation in Aqueous Media
Authors: Kawabata Kohei , Kanoh Momoka , Okazaki Mayu , Maeda Rina , Mori Satomi , Akimoto Shiori , Inagaki Masanori , Nishi Hiroyuki
Published: June 2020

It is important to develop a photostabilization strategy to ensure the quality of photosensitive compounds, including pharmaceuticals. This study focused on the protective effects of 20 amino acids on the photodegradation of naproxen (NX), a photosensitive pharmaceutical, to clarify the important nature of a good photostabilizer. Our previous report indicated the photodegradability of NX and the protective effects of some antioxidants on its photodegradation, therefore, this compound was used as a model compound. The degradation of NX in aqueous media during ultraviolet light (UV) irradiation and the protective effects of selected amino acids were monitored through high-performance liquid chromatography (HPLC), equipped with a reverse-phase column. Addition of cysteine, tryptophan, and tyrosine induced the significant suppression of NX photodegradation after UV irradiation for 3 h (residual amount of NX; 15.35%, 6.82%, and 15.64%, respectively). Evaluation of the antioxidative activity and UV absorption spectrum showed that cysteine suppressed NX degradation through its antioxidative ability, while tryptophan and tyrosine suppressed it through their UV filtering ability. Furthermore, three amino acids at higher concentrations (more than 100 µmol/L) showed more protective effects on NX photodegradation. For 10 mmol/L, residual amounts of NX with cysteine, tryptophan, and tyrosine were 58.51%, 69.34%, and 82.40%, respectively. These results showed the importance of both photoprotective potencies (antioxidative potency and UV filtering potency) and stability to UV irradiation for a good photostabilizer of photosensitive pharmaceuticals.
Nora’s Ironic Longing for Christlike Love: Self-Sacrifice, Self-Love, and the “Religion of Torvald” in Ibsen’s A Doll House
Authors: Urban David V.
Published: June 2020

This essay argues that in Ibsen’s A Doll House, both Nora and her husband, Torvald Helmer, exhibit a “religion of Torvald” characterized by their respective devotion to Torvald himself. However, while Torvald’s devotion to himself is characterized by self-love and self-centeredness, Nora’s “religion of Torvald” is based on her expectation that Torvald will exhibit the Christlike office of bearing Nora’s sins by proclaiming himself guilty of her crime of forgery, thus rendering her blameless. After Torvald shatters Nora’s expectations by reacting with abuse and cowardice to the news of Nora’s forgery and Krogstad’s consequent blackmail, Nora loses her previous faith in Torvald and instead exhibits a preoccupation with her own self that, ironically enough, imitates the self-love of the “religion of Torvald” that Torvald has practiced all along.
Bilateral Breast Edema: Case Report and Review of the Literature
Authors: Vouxinou Andriani D. , Iatrakis Georgios M. , Zervoudis Stefanos , Bothou Anastasia , Tsitsiou Sofia , Markja Anisa , Margelis Zois , Tooulias Christos A. , Antoniou Evangelia
Published: June 2020

Both benign and malignant conditions related to regional or systemic disorders could be included in the differential diagnosis of bilateral breast edema. Some of them are often unilateral, including stromal infiltration and lymphatic obstruction presented in “peau d’ orange”, which is the usual presentation of breast cancer. However, the term “idiopathic” could be included in the spectrum of diagnoses. Here, we present a woman of 78 years old who came into our breast unit with a bilateral, painless edema of the breasts (appeared one month ago). Clinical examination revealed that both breasts were swollen with widespread erythema and the appearance of an orange peel/“peau d’ orange”. On palpation, the breasts were not sensitive, and no tumor was palpable. However, clinically palpable lymph nodes were found in both axillas. Her temperature was normal. The breast edema could not be explained from her medical history nor the medications taken. Breast ultrasound, Mammography and Magnetic Resonance Imaging were non-conclusive (BI-RADS 0) and bilateral core biopsy was negative for cancer. Anti-inflammatory plus antibiotic therapy was prescribed for 10 days and at the end of treatment, regional redness and edema were disappeared and reduced, respectively. Total recovery was found one month after the initial findings. It can be concluded that bilateral breast edema is correlated to regional or systemic conditions or it is presented as an “idiopathic” disorder of unknown etiology.
An Amputated Tongue—The Consequences of a Human Bite
Authors: Hardwick Constance , Cameron Alice , Puryer James
Published: June 2020

Drug-related hospital admissions are common, and up to 25% of patients presenting to emergency departments with injuries test positive for alcohol and drug use. This case reports on a 55-year-old male who attended the emergency department (ED) at the Royal United Hospital, Bath, UK. He presented after sustaining significant soft tissue trauma to his tongue, following recreational drug use of an unknown substance. His injuries included the amputation and loss of the anterior third of his tongue, having suffered a bite from another individual. This unusual case describes the patient’s injuries and subsequent management, both in the emergency department and during follow-up. This case will be of benefit to clinicians from many disciplines including dentists, oral and maxillofacial surgeons, ENT surgeons and speech and language therapists.
Quantification of Precipitation Using Polarimetric Radar Measurements during Several Typhoon Events in Southern China
Authors: Xia Qiulei , Zhang Wenjuan , Chen Haonan , Lee Wen-Chau , Han Lei , Ma Yu , Liu Xiantong
Published: June 2020

Accurate quantitative precipitation estimation (QPE) during typhoon events is critical for flood warning and emergency management. Dual-polarization radar has proven to have better performance for QPE, compared to traditional single-polarization radar. However, polarimetric radar applications have not been extensively investigated in China, especially during extreme events such as typhoons, since the operational dual-polarization system upgrade only happened recently. This paper extends a polarimetric radar rainfall system for local applications during typhoons in southern China and conducts comprehensive studies about QPE and precipitation microphysics. Observations from S-band dual-polarization radar in Guangdong Province during three typhoon events in 2017 are examined to demonstrate the enhanced radar rainfall performance. The microphysical properties of hydrometeors during typhoon events are analyzed through raindrop size distribution (DSD) data and polarimetric radar measurements. The stratiform precipitation in typhoons presents lower mean raindrop diameter and lower raindrop concentration than that of the convection precipitation. The rainfall estimates from the adapted radar rainfall algorithm agree well with rainfall measurements from rain gauges. Using the rain gauge data as references, the maximum normalized mean bias ( N M B ) of the adapted radar rainfall algorithm is 20.27%; the normalized standard error ( N S E ) is less than 40%; and the Pearson’s correlation coefficient ( C C ) is higher than 0.92. For the three typhoon events combined, the N S E and N M B are 36.66% and -15.78%, respectively. Compared with several conventional radar rainfall algorithms, the adapted algorithm based on local rainfall microphysics has the best performance in southern China.
Using Linear Regression, Random Forests, and Support Vector Machine with Unmanned Aerial Vehicle Multispectral Images to Predict Canopy Nitrogen Weight in Corn
Authors: Lee Hwang , Wang Jinfei , Leblon Brigitte
Published: June 2020

The optimization of crop nitrogen fertilization to accurately predict and match the nitrogen (N) supply to the crop N demand is the subject of intense research due to the environmental and economic impact of N fertilization. Excess N could seep into the water supplies around the field and cause unnecessary spending by the farmer. The drawbacks of N deficiency on crops include poor plant growth, ultimately reducing the final yield potential. The objective of this study is to use Unmanned Aerial Vehicle (UAV) multispectral imagery to predict canopy nitrogen weight (g/m2) of corn fields in south-west Ontario, Canada. Simple/multiple linear regression, Random Forests, and support vector regression (SVR) were established to predict the canopy nitrogen weight from individual multispectral bands and associated vegetation indices (VI). Random Forests using the current techniques/methodologies performed the best out of all the models tested on the validation set with an R2 of 0.85 and Root Mean Square Error (RMSE) of 4.52 g/m2. Adding more spectral variables into the model provided a marginal improvement in the accuracy, while extending the overall processing time. Random Forests provided marginally better results than SVR, but the concepts and analysis are much easier to interpret on Random Forests. Both machine learning models provided a much better accuracy than linear regression. The best model was then applied to the UAV images acquired at different dates for producing maps that show the spatial variation of canopy nitrogen weight within each field at that date.
A Fast Bistatic ISAR Imaging Approach for Rapidly Spinning Targets via Exploiting SAR Technique
Authors: Yang Zhijun , Li Dong , Tan Xiaoheng , Liu Hongqing , Liao Guisheng
Published: June 2020

Because of the large range of cell migration (RCM) and nonstationary Doppler frequency modulation (DFM) produced by non-cooperative targets with rapid spinning motions, it is difficult to efficiently generate a well-focused bistatic inverse synthetic aperture radar (ISAR) by use of the conventional imaging algorithms. Utilizing the property of the inherent azimuth spatial invariance in strip-map synthetic aperture radar (SAR) imaging mode, in this work, an efficient bistatic ISAR imaging approach based on circular shift operation in the range-Doppler (RD) domain is proposed. First, echoes of rapidly spinning targets are transformed into the RD domain, whose exact analytical is derived on the basis of the principle of stationary phase (POSP). Second, the RCM is corrected by using an efficient circular shift operation in the RD domain. By doing so, the energies of a scatterer that span multiple range cells are concentrated into the same range cell, and the time-varying DFM can also be compensated along the rotating radius direction. Compared with existing methods, the proposed method has advantages in its computational complexity, avoiding the interpolation and multi-dimensional search operation, and in its satisfactory imaging performance under low signal to noise ratio (SNR) conditions thanks to the two-dimensional coherent integration gain utilized. Finally, several numerical simulations are conducted to show the validity of the proposed algorithm.
High-Sensitivity Goos-Hänchen Shifts Sensor Based on BlueP-TMDCs-Graphene Heterostructure
Authors: Han Lei , Hu Zhimin , Pan Jianxing , Huang Tianye , Luo Dapeng
Published: June 2020

Surface plasmon resonance (SPR) with two-dimensional (2D) materials is proposed to enhance the sensitivity of sensors. A novel Goos–Hänchen (GH) shift sensing scheme based on blue phosphorene (BlueP)/transition metal dichalogenides (TMDCs) and graphene structure is proposed. The significantly enhanced GH shift is obtained by optimizing the layers of BlueP/TMDCs and graphene. The maximum GH shift of the hybrid structure of Ag-Indium tin oxide (ITO)-BlueP/WS2–graphene is −2361λ with BlueP/WS2 four layers and a graphene monolayer. Furthermore, the GH shift can be positive or negative depending on the layer number of BlueP/TMDCs and graphene. For sensing performance, the highest sensitivity of 2.767 × 107λ/RIU is realized, which is 5152.7 times higher than the traditional Ag-SPR structure, 2470.5 times of Ag-ITO, 2159.2 times of Ag-ITO-BlueP/WS2, and 688.9 times of Ag-ITO–graphene. Therefore, such configuration with GH shift can be used in various chemical, biomedical and optical sensing fields.
C2DAN: An Improved Deep Adaptation Network with Domain Confusion and Classifier Adaptation
Authors: Sun Han , Chen Xinyi , Wang Ling , Liang Dong , Liu Ningzhong , Zhou Huiyu
Published: June 2020

Deep neural networks have been successfully applied in domain adaptation which uses the labeled data of source domain to supplement useful information for target domain. Deep Adaptation Network (DAN) is one of these efficient frameworks, it utilizes Multi-Kernel Maximum Mean Discrepancy (MK-MMD) to align the feature distribution in a reproducing kernel Hilbert space. However, DAN does not perform very well in feature level transfer, and the assumption that source and target domain share classifiers is too strict in different adaptation scenarios. In this paper, we further improve the adaptability of DAN by incorporating Domain Confusion (DC) and Classifier Adaptation (CA). To achieve this, we propose a novel domain adaptation method named C2DAN. Our approach first enables Domain Confusion (DC) by using a domain discriminator for adversarial training. For Classifier Adaptation (CA), a residual block is added to the source domain classifier in order to learn the difference between source classifier and target classifier. Beyond validating our framework on the standard domain adaptation dataset office-31, we also introduce and evaluate on the Comprehensive Cars (CompCars) dataset, and the experiment results demonstrate the effectiveness of the proposed framework C2DAN.
Stone Paper as a New Substrate to Fabricate Flexible Screen-Printed Electrodes for the Electrochemical Detection of Dopamine
Authors: Varodi Codruta , Pogacean Florina , Gheorghe Marin , Mirel Valentin , Coros Maria , Barbu-Tudoran Lucian , Stefan-van Staden Raluca-Ioana , Pruneanu Stela
Published: June 2020

Flexible screen-printed electrodes (HP) were fabricated on stone paper substrate and amperometrically modified with gold nanoparticles (HP-AuNPs). The modified electrode displayed improved electronic transport properties, reflected in a low charge-transfer resistance (1220 Ω) and high apparent heterogeneous electron transfer rate constant (1.94 × 10−3 cm/s). The voltammetric detection of dopamine (DA) was tested with HP and HP-AuNPs electrodes in standard laboratory solutions (pH 6 phosphate-buffered saline (PBS)) containing various concentrations of analyte (10−7–10−3 M). As expected, the modified electrode exhibits superior performances in terms of linear range (10−7–10−3 M) and limit of detection (3 × 10−8 M), in comparison with bare HP. The determination of DA was tested with HP-AuNPs in spiked artificial urine and in pharmaceutical drug solution (ZENTIVA) that contained dopamine hydrochloride (5 mg/mL). The results obtained indicated a very good DA determination in artificial urine without significant matrix effects. In the case of the pharmaceutical drug solution, the DA determination was affected by the interfering species present in the vial, such as sodium metabisulfite, maleic acid, sodium chloride, and propylene glycol.
Assessing the Activity of Individual Group-Housed Broilers Throughout Life Using a Passive Radio Frequency Identification System—A Validation Study
Authors: van der Sluis Malou , de Haas Yvette , de Klerk Britt , Rodenburg T. Bas , Ellen Esther D.
Published: June 2020

Individual data are valuable for assessing the health, welfare and performance of broilers. In particular, data on the first few days of life are needed to study the predictive value of traits recorded early in life for later life performance. However, broilers are generally kept in groups, which hampers individual identification and monitoring of animals. Sensor technologies may aid in identifying and monitoring individual animals. In this study, a passive radio frequency identification (RFID) system was implemented to record broiler activity, in combination with traditional video recordings. The two main objectives were (1) to validate the output of the RFID system by comparing it to the recorded locations on video, and (2) to assess whether the number of antennas visited per unit time could serve as a measure of activity, by comparing it to the distance recorded on video and to the distance moved as recorded using a validated ultra-wideband (UWB) tracking system. The locations recorded by the RFID system exactly matched the video in 62.5% of the cases, and in 99.2% of the cases when allowing for a deviation of one antenna grid cell. There were moderately strong Spearman rank correlations between the distance recorded with the RFID system and the distance recorded from video (rs = 0.82) and between UWB and RFID (rs = 0.70) in approximately one-hour recordings, indicating that the RFID system can adequately track relative individual broiler activity, i.e., the activity level of a broiler in comparison to its group members. As the RFID tags are small and lightweight, the RFID system is well suited for monitoring the individual activity of group-housed broilers throughout life.
Three-Event Energy Detection with Adaptive Threshold for Spectrum Sensing in Cognitive Radio Systems
Authors: Martian Alexandru , Al Sammarraie Mahmood Jalal Ahmad , Vlădeanu Călin , Popescu Dimitrie C.
Published: June 2020

Implementation of dynamic spectrum access (DSA) in cognitive radio (CR) systems requires the unlicensed secondary users (SU) to implement spectrum sensing to monitor the activity of the licensed primary users (PU). Energy detection (ED) is one of the most widely used methods for spectrum sensing in CR systems, and in this paper we present a novel ED algorithm with an adaptive sensing threshold. The three-event ED (3EED) algorithm for spectrum sensing is considered for which an accurate approximation of the optimal decision threshold that minimizes the decision error probability (DEP) is found using Newton’s method with forced convergence in one iteration. The proposed algorithm is analyzed and illustrated with numerical results obtained from simulations that closely match the theoretical results and show that it outperforms the conventional ED (CED) algorithm for spectrum sensing.
Long-Term Evaluation and Calibration of Low-Cost Particulate Matter (PM) Sensor
Authors: Lee Hoochang , Kang Jiseock , Kim Sungjung , Im Yunseok , Yoo Seungsung , Lee Dongjun
Published: June 2020

Low-cost light scattering particulate matter (PM) sensors have been widely researched and deployed in order to overcome the limitations of low spatio-temporal resolution of government-operated beta attenuation monitor (BAM). However, the accuracy of low-cost sensors has been questioned, thus impeding their wide adoption in practice. To evaluate the accuracy of low-cost PM sensors in the field, a multi-sensor platform has been developed and co-located with BAM in Dongjak-gu, Seoul, Korea from 15 January 2019 to 4 September 2019. In this paper, a sample variation of low-cost sensors has been analyzed while using three commercial low-cost PM sensors. Influences on PM sensor by environmental conditions, such as humidity, temperature, and ambient light, have also been described. Based on this information, we developed a novel combined calibration algorithm, which selectively applies multiple calibration models and statistically reduces residuals, while using a prebuilt parameter lookup table where each cell records statistical parameters of each calibration model at current input parameters. As our proposed framework significantly improves the accuracy of the low-cost PM sensors (e.g., RMSE: 23.94 → 4.70 μ g/m 3 ) and increases the correlation (e.g., R 2 : 0.41 → 0.89), this calibration model can be transferred to all sensor nodes through the sensor network.
Blockchain Tree as Solution for Distributed Storage of Personal ID Data and Document Access Control
Authors: Kushch Sergii , Baryshev Yurii , Ranise Silvio
Published: June 2020

This paper introduces a new method of Blockchain formation for reliable storage of personal data of ID-card holders. In particular, the model of the information system is presented, the new structure of smart ID-cards and information on these cards are proposed. The new structure of Blockchain, “Blockchain Tree”, allows not only to store information from ID-cards but also to increase the level of security and access control to this information. The proposed Subchains system allows us to integrate Blockchain of the lower level to Blockchain of the higher level, allowing us to create a multilevel protected system.