bluuebunny/crossref_metadata_2025 huggingface dataset:
DIABETES MELLITUS AND HEALTH EDUCATION’S ROLE IN PATIENT MANAGEMENT: A LITERATURE REVIEW
Authors: Pusparini Ajeng Defriyanti , Zuraida Reni , Susianti Susianti
Published: March 2022

Diabetes Melitus (DM) merupakan penyakit kronis disebabkan organ pankreas tidak dapat memproduksi insulin dalam jumlah yang cukup atau ketika tubuh tidak efektif menggunakan insulin yang diproduksinya sehingga terjadi kadar gula darah yang meningkat. Penderita DM terus meningkat setiap tahunnya selama beberapa dekade terakhir. Sekitar 463,0 juta atau 9,3 % dari orang dewasa berusia 20-79 tahun di seluruh dunia menderita DM pada tahun 2019. Perlunya pengelolaan dan pencegahan DM dimana melibatkan multi disiplin ilmu sesuai dengan kompetensi dan penugasan klinis. Beberapa upaya penatalaksaan dalam upaya pengelolaan dan pencegahan penyakit DM antara lain edukasi, melakukan aktifitas fisik, pengaturan diet dan pola makan, terapi farmakologi dan pemantauan laboratorium secara berkala. Pengelolaan secara komprehensif difokuskan terhadap upaya mengubah perilaku ke arah perilaku sehat dan modifikasi gaya hidup. Upaya yang dilakukan untuk meningkatkan keberhasilan dalam pengelolaan DM adalah dengan cara pendidikan kesehatan. Pendidikan kesehatan dapat meningkatkan kontrol glikemik dan dapat meningkatkan pemahaman serta kemampuan pasien dan keluarga dalam perawatan diri pasien DM sehingga dapat mengurangi komplikasi dan rehospitalisasi.
AKTIVITAS ANTIBAKTERI SEDIAAN KUMUR EKSTRAK ETIL ASETAT DAUN KEMANGI (Ocimum sanctum L.) TERHADAPStreptococcus mutans
Authors: Dola Meilfi Willya , Nofita Nofita , Ulfa Ade Maria
Published: March 2022

Daun kemangi (Ocimum sanctum L.) telah diketahui memiliki manfaat untuk mengobati penyakit yang ada dalam rongga mulut seperti keries gigi dan bau mulut yang disebabkan oleh bakteri yaitu Streptococcus mutans. Penelitian ini bertujuan untuk mengetahui aktivitas dari ekstrak etil asetat daun kemangi serta konsentrasi ekstrak dalam sediaan kumur yang efektif dalam menghambat pertumbuhan Streptococcus mutans. Metode ekstraksi yang digunakan pada penelitian ini adalah perkolasi dan uji aktivitas antibakteri ekstrak daun kemangi dan sediaan kumur ekstrak daun kemangi menggunakan metode disk cakram. Aktivitas antibakteri pada masing-masing konsentrasi ekstrak etil asetat daun kemangi dan sediaan kumur ekstrak etil asetat daun kemangi memiliki aktivitas sebagai antibakteri, aktivitas ekstrak daun kemangi terbesar pada konsentrasi 10% dengan diameter daya hambat sebesar 16,28 mm, sedangkan diameter daya hambat terkecil pada konsentrasi 0,625% sebesar 5,10 mm. Sediaan kumur esktak daun kemangi (Ocimum sanctum L.) konsentrasi 2,5%  memiliki diameter daya hambat sebesar 15,19 mm dan paling kecil konsentrasi 0,625% sebesar 12,92 mm dan tidak berbeda dengan K(+) sebesar 13,65 mm.
PENGARUH KOMPETENSI DAN LINGKUNGAN KERJA TERHADAP KINERJA PEGAWAI
Authors: Abdi Nurgunawan , Wahid Muhsin
Published: March 2022

Tujuan penelitian ini adalah 1) untuk menganalisis pengaruh kompetensi terhadap kinerja pegawai pada Dinas Kesehatan Kabupaten Kepulauan Selayar, dan  2) untuk menganalisis pengaruh lingkungan kerja terhadap kinerja pegawai pada Dinas Kesehatan Kabupaten Kepulauan Selayar. Metode analisis yang digunakan dalam penelitian ini adalah metode analisis Regresi Berganda. Data penelitian diperoleh dari pegawai Dinas Kesehatan Kabupaten Kepulauan Selayar. Pendekatan penelitian adalah pendekatan kausal yang bersifat explanatory. Hasil penelitian ini menunjukkan bahwa: 1) Kompetensi berpengaruh positif dan signifikan terhadap kinerja pegawai pada Dinas Kesehatan Kabupaten Kepulauan Selayar, hal ini berarti bahwa dengan adanya kompetensi yang tinggi, maka kinerja pegawai akan semakin baik sehingga akan menghasilkan kualitas kerja seperti yang diharapkan oleh Dinas Kesehatan Kabupaten Kepulauan Selayar, dan 2) Lingkungan kerja berpengaruh positif dan signifikan terhadap kinerja pegawai pada Dinas Kesehatan Kabupaten Kepulauan Selayar, hal ini berarti bahwa dengan adanya lingkungan kerja yang ada, telah sangat sesuai dengan apa yang diharapkan oleh pegawai Dinas Kesehatan Kabupaten Kepulauan Selayar, sehingga tugas dan tanggungjawab yang telah diberikan dapat terlaksana dengan baik dan sesuai dengan waktu yang telah ditentukan oleh pimpinan
PENGARUH PENGETAHUAN, SIKAP KERJA DAN PENGALAMAN KERJA TERHADAP KINERJA KARYAWAN
Authors: Alias Alias , Serang Serlin
Published: March 2022

Penelitian ini untuk mengetahui pengaruh pengetahun, sikap kerja, dan pengalaman kerja terhadap kinerja karyawan pada Kantor BPJS Ketenagakerjaan Cabang Makassar, serta untuk menganalisis apakah pengetahuan, sikap dan pengalaman secara bersama-sama berpengaruh terhadap kinerja karyawan pada Kantor BPJS Ketenagakerjaan Cabang Makassar. Penelitian ini menggunakan data kuesioner atau angket-angket, yang dilakukan dengan menyebarkan angket kepada pihak yang dijadikan responden dalam penelitian ini. Sedangkan teknik analisis data adalah uji kualitas instrumen, uji asumsi klasik, analisis regresi linear berganda, serta pengujian hipotesis. Hasil penelitian menemukan bahwa pengetahuan berpengaruh positif dan signifikan terhadap kinerja karyawan pada Kantor BPJS Ketenaga-kerjaan Cabang Makassar. Sikap berpengaruh positif dan signifikan terhadap kinerja karyawan pada Kantor BPJS Ketenagakerjaan Cabang Makassar, hal ini dapat dikatakan bahwa sikap memberikan pengaruh yang bermakna dalam peningkatan kinerja karyawan. Pengalaman kerja berpengaruh positif dan signifikan terhadap kinerja karyawan pada Kantor BPJS Ketenagakerjaan Cabang Makassar, hal ini  dapat dikatakan bahwa pengalaman kerja dapat memberikan pengaruh yang berarti terhadap peningkatan kinerja karyawan. Berdasarkan hasil pengujian secara serempak yang menunjukkan bahwa pengetahuan, sikap dan pengalaman kerja secara bersama-sama berpengaruh terhadap kinerja karyawan.
PENGARUH PENGALAMAN, INDEPENDENSI DAN SKEPTISME PROFESIONAL AUDITOR TERHADAP PENDETEKSIAN FRAUD
Authors: Dasila Rifqa Ayu , Hajering Hajering
Published: March 2022

This study aims to examine the influence of auditor experience, independence and professional auditor skepticism on Fraud detection . This research was conducted at inspectorate office in South Sulawesi Province, where auditors as sample in research. Sampling using simple random sampling, with respondent sample 35. The type of data used in this study is the primary data. Data was collected by using questioner. The data analysis technique used multiple regression by using SPSS program. The result of the research shows that the Aauditor experience,  independence and professional auditor skepticism has positive and significantly influence to fraud detection.
PENGARUH KEPUASAN KERJA, STRES KERJA DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN
Authors: Dirga Ilyas Wira , Arfah Aryati
Published: March 2022

Penelitian ini bertujuan menganalisis pengaruh signifikan variabel kepuasan kerja, stress kerja dan lingkungan kerja terhadap kinerja kerja karyawan pada PT. Bumi Jaya Abadi Makassar. Penelitian ini menggunakana data primer melalui survei sebanyak 79 orang. Hasil penelitian ini menemukan bahwa secara simultan dan parsial terdapat pengaruh signifikan variabel kepuasan kerja, stress kerja dan lingkungan kerja terhadap kinerja kerja karyawan pada PT. Bumi Jaya Abadi Makassar. Variabel yang paling dominan berkontribusi memberikan sumbangan terhadap kinerja kerja karyawan pada PT. Bumi Jaya Abadi Makassar adalah lingkungan kerja.
Wheat–Lentil Mixed Cropping System Productivity Under Varied Irrigation Levels
Authors: Neogi MG , Biswas JC , Khan MM , Rashid MM
Published: March 2022

The study on mixed cropping of lentil and wheat was conducted under three levels of irrigation. Wheat at 10, 15, 20, 25, 30, 35, 40, 45 and 50% of the normal seed rates were mixed with full seed rate of lentil to find out a suitable mixing rate of wheat for maximum total yield from unit land. The study was conducted in a split plot design with three replications. Lentil yields obtained with single and two irrigations were identical and higher than with no irrigation. The highest wheat yield was obtained with two irrigations. Total yield was the highest with application of two irrigations. Mixing different proportions of wheat with lentil produced 95-171% additional yield over sole cropping of lentil. Mixing of wheat at 25-35% with lentil was found to be judicious for obtaining maximum total yields. The highest protein yield was obtained with 30-35% and 35% mixing rates of wheat at zero and single irrigation levels. Growing wheat with lentil resulted in increased protein yield in wheat than sole cropping. The highest land equivalent ratio (LER) values were obtained when 30-35% of wheat seed rate were mixed with lentil. Application of two irrigations resulted in high LER values. It is concluded that use of 35% of wheat seed rate along with full seed rate of lentil under two levels of irrigations would be the best mixing ratio for obtaining the highest wheat and total grain yield.
Ann. Bangladesh Agric. (2021) 25 (1) : 1-10
Kombinasi Metode AHP dan TOPSIS pada Penentuan Prioritas Proyek Air Bersih Di Kabupaten Asahan
Authors: Lestari Maya , Yusda Riki Andri , Latiffani Chitra
Published: March 2022

Abstract: Most of the area in Asahan Regency is a plantation and coastal area where some of the people work as farmers and fishermen. Coastal areas are still lagging behind because they are far from urban areas so that the government pays little attention to it, especially regarding clean water. Clean water in the area can be said to be unfit for use. So that people find it difficult to get clean water for drinking, washing and bathing. These problems can be solved by programs to improve clean water infrastructure and facilities, such as drilling wells and allocating river water, so that they can provide optimal services for clean water, which has a very strong relationship with the economic growth of a region and the socio-cultural life of the community. Determining the priority scale for clean water must look at various criteria so as to produce accurate and precise results. The criteria that are considered in determining the priority of clean water are: Water Condition, Population, Regional Economic Potential, Cost, Level of Interest. To determine the priority of clean water projects at the Public Works and Spatial Planning Office of Asahan Regency, a decision support system is needed that can assist in determining which villages have the right to be prioritized in the priority of clean water projects more effectively and efficiently. Keywords: Clean water; AHP; TOPSIS; Asahan  Abstrak: Sebagian Besar Wilayah di Kabupaten Asahan merupakan wilayah perkebunan dan pesisir yang sebagian masyarakatnya bekerja sebagai petani dan nelayan. Di wilayah Pesisir masih tertinggal karena letaknya yang jauh dari perkotaan sehingga kurang diperhatikan oleh pemerintah, terutama mengenai air bersih. Air bersih di wilayah tersebut bisa di bilang tidak layak untuk digunakan. Sehingga masyarakat kesulitan untuk mendapatkan air bersih baik itu untuk diminum, menyuci dan mandi. Masalah tersebut dapat diselesaikan dengan program peningkatan prasarana dan sarana air bersih seperti membuat sumur bor dan pengalokasiam air sungai, agar tetap dapat memberikan pelayanan yang optimal terhadap air bersih memiliki keterkaitan yang sangat kuat dengan pertumbuhan ekonomi suatu wilayah maupun sosial budaya kehidupan masyarakat. Penentuan skala prioritas air bersih tersebut harus melihat dari berbagai kriteria sehingga menghasilkan hasil yang akurat dan tepat. Adapun kriteria yang menjadi pertimbangan dalam penentuan prioritas air bersih ialah: Kondisi Air, Jumlah Penduduk, Potensi Ekonomi Daerah, Biaya, Tingkat Kepentingan. Untuk penentuan proyek prioritas air bersih di Dinas Pekerjaan Umum dan Penataan Ruang Kabupaten Asahan maka diperlukan sistem pendukung keputusan yang dapat membantu dalam menentukan desa mana yang berhak didahulukan dalam prioritas proyek air bersih dengan lebih efektif dan efisien. Kata kunci: Air bersih; AHP; TOPSIS; Asahan
Peramalan Permintaan Minyak dengan Metode Single Moving Average Pada PT. Alam Jaya Wirasentosa
Authors: Viranika Nadya , Ramdhan William , Rahayu Elly
Published: March 2022

Abstract: PT. Alam Jaya Wirasentosa which is located in Hessa Air Genting, Air Batu District, Asahan Regency, North Sumatra. This company is engaged in sales and distribution which has a fairly wide coverage on the island of Sumatra. PT. Alam Jaya Wirasentosa sells Indofood's main products, one of which is bimoli cooking oil. Constraints experienced by PT. Alam Jaya Wirasentosa often has problems with stock availability due to the large number of product requests from consumers. In addition, there are times when there is too much inventory (over stock) that results in too high a cost burden to store and maintain materials during storage in the warehouse even though the goods still have opportunity costs (funds that can be invested / invested in more profitable things). In this study, the SMA method is used to solve the problem of predicting the demand for cooking oil in the next period. In addition, the purpose of this study is to determine the forecasting system used by PT. Alam Jaya Wirasentosa in forecasting the demand for Cooking Oil each month and implementing the Single Moving Average Method in forecasting the Demand for Cooking Oil, especially Bimoli cooking oil. At PT. Alam Jaya Wirasentosa. Keywords: Forecasting; Single Moving Average; Bimoli Cooking Oil; PT. Alam Jaya Wirasentosa  Abstrak: PT. Alam Jaya Wirasentosa yang berlokasi di Hessa Air Genting, Kecamatan Air Batu, Kabupaten Asahan, Sumatera Utara.Perusahaan ini bergerak dalam bidang penjualan dan distribusi yang memiliki cakupan cukup luas di pulau Sumatera. PT. Alam Jaya Wirasentosa menjual produk utama Indofood salah satunya minyak goreng bimoli. Kendala yang dialami oleh PT. Alam Jaya Wirasentosa sering mengalami masalah ketersediaan stock barang dikarenakan banyaknya permintaan produk dari konsumen. Selain itu ada masa dimana terlalu banyaknya persediaan (over stock) yang ada sehingga mengakibatkan terlalu tingginya beban biaya guna menyimpan dan memelihara bahan selama penyimpanan di gudang padahal barang tersebut masih mempunyai opportunity cost (dana yang bisa ditanamankan / diinvestasikan pada hal yang lebih menguntungkan). Pada penelitian ini menggunakan metode SMA dalam memecahkan masalah prediksi permintaan minyak goreng pada periode selanjutnya. Selain itu tujuan penelitian ini adalah untuk mengetahui sistem peramalan yang digunakan oleh PT. Alam Jaya Wirasentosa dalam meramalkan permintaan Minyak Goreng tiap bulannya dan mengimplementasikan Metode Single Moving Average dalam meramalkan Permintaan Minyak Goreng khusunya minyak goreng Bimoli Pada PT. Alam Jaya Wirasentosa. Kata Kunci: Peramalan, Single Moving Average, Minyak Goreng Bimoli, PT. Alam Jaya Wirasentosa,
Comparing Changes in Corneal Astigmatism Using Scheimpflug Camera after Epiblepharon Correction Surgery
Authors: Lee Ji Hye , Kim Sung Eun , Byun Yong-Soo , Yang Suk-Woo
Published: March 2022

Purpose: To evaluate the changes in corneal astigmatism before and after epiblepharon correction surgery with a Scheimpflug camera.Methods: From April, 2019, to June, 2020, 48 eyes of 24 patients underwent epiblepharon correction surgery. The patients were divided into two subgroups by age and their best corrected visual acuity (BCVA) and corneal anterior and posterior astigmatism were compared before and after correction surgery.Results: There was no difference in BCVA after the correction surgery. To assess the changes in the keratometric value and astigmatism after epiblepharon surgery, a Scheimpflug camera was used. The anterior flat and mean keratometry changed from 42.10 ± 1.46 to 42.43 ± 1.10 D (p = 0.035) and from 42.97 ± 1.26 to 43.21 ± 1.15 D (p = 0.012), respectively, while the posterior corneal astigmatism changed from 0.44 ± 0.31 to 0.35 ± 0.17 D (p = 0.047). There were no significant changes in steep keratometry (p = 0.191) or anterior corneal astigmatism (p = 0.126).Conclusions: There were significant changes after epiblepharon correction surgery in anterior keratometry reading and posterior corneal astigmatism.
Presumed Latent Tuberculosis-related Intermediate Uveitis Manifesting as Recurrent Vitreous Hemorrhage
Authors: Lee Joo Hwang , Seo Yong Hoon , Lee Eun Chul
Published: March 2022

Purpose: We report a case of recurrent vitreous hemorrhage in a patient with presumed latent tuberculosis-related intermediate uveitis, and we review the literature.Case summary: A 58-year-old male visited our clinic complaining of ocular pain, conjunctival hyperemia, decreased vision, and uncontrolled intraocular pressure (IOP) in the left eye. The best-corrected visual acuity (BCVA) was 0.4 and the IOP of the left eye was 34 mmHg. Slit lamp examination revealed conjunctival hyperemia, corneal edema, and inflammatory cells in the anterior chamber and anterior vitreous; fundus examination revealed mild vitreous opacity attributable to vitritis. The high IOP and the intraocular inflammation were treated with antiglaucoma agents and corticosteroids under the impression of chronic anterior uveitis and uveitic glaucoma. Of the tests performed to identify the cause of the uveitis-related vitreous hemorrhage, the interferon-gamma release assay was positive. A presumptive diagnosis of latent tuberculosis-related uveitis was made after pulmonary tuberculosis was excluded by our respiratory internal medicine department. Isoniazid was administered for 9 months. The vitreous hemorrhage recurred 1 month after antituberculosis therapy commenced but, at 2 months, all of the hemorrhage was absorbed and the BCVA improved to 1.0 without further recurrence.Conclusions: Intraocular tuberculosis can present with various clinical manifestations. If tuberculosis-related uveitis is presumed, tests for latent and manifest tuberculosis should be scheduled to allow of early diagnosis and immediate antituberculosis therapy.
Sistema Semi-Automatizado para Procesos Universitario de Transacciones Monetarias e Identificación por Medio de Tecnología Near Field Communication
Authors: Tunon Modaldo , Yao Luis , Mastrolinardo Roderick
Published: March 2022

NFC (Near Field Communication) es una tecnología innovadora, flexible y relativamente económica para la intercomunicación de los dispositivos mecatrónicos tanto fijos como móviles. Una de las características principales que lo distingue de tecnologías similares es su capacidad de comunicación bidireccional, es decir, puede enviar y recibir información de una fuente externa, esto abre muchas posibilidades para aplicaciones relacionadas a credenciales y transacciones. En este trabajo nos fundamentamos en crear una aplicación web que pueda aprovechar las capacidades de esta tecnología, para ofrecer una plataforma digital web que permita realizar funciones de identificación y transacciones comunes dentro de una organización. Esta plataforma tiene la intención de crear un ecosistema que incentive la utilización del carnet estudiantil dentro del campus de la Universidad Tecnológica de Panamá, ofreciendo funcionalidades de verificación de credenciales para aumentar la seguridad dentro del área de la institución; funcionalidades como opción alterna de pago para acelerar los procesos repetitivos relacionados con pagos internos, que muchas veces son ineficientes por el factor humano dentro del proceso. Se espera que la comparación de los modelos en este proyecto demuestre que utilizando un sistema digital e innovador se podría disminuir considerablemente el tiempo en espera promedio de los usuarios que realizan procesos de pagos dentro de la Universidad Tecnológica de Panamá, así como cualquier otra institución.
Técnicas de machine learning aplicadas a la evaluación del rendimiento y a la predicción de la deserción de estudiantes universitarios, una revisión.
Authors: Cruz Edmanuel , González Marvin , Rangel Jose Carlos
Published: March 2022

En los últimos años, técnicas de Inteligencia Artificial (IA) como el aprendizaje automático o Machine Learning (ML) y el Aprendizaje profundo o Deep Learning (DL), han impactado de forma positiva el avance de distintos campos del conocimiento entre ellos la educación.  La educación es un importante motor de todas las sociedades, permite a los individuos ser más productivos y resolver problemas con mayor efectividad aplicando generalmente enfoques creativos. En la educación se ha utilizado las técnicas de ML antes mencionadas para distintas tareas entre ellas predicción de deserción y ayuda al rendimiento del estudiante. En este estudio analizaremos los trabajos más relevantes en estos campos, otorgando una perspectiva de cómo han influenciado los algoritmos de ML y DL en la educación.
Зміст моделювання оперативно-службової діяльності прикордонного загону в умовах виникнення ситуацій техногенного характеру під час особливого періоду
Authors: Polonchuk Vasil , Sinishin Mikhail , Torichnyi Vadym
Published: March 2022

Мета роботи: полягає в аналізі змісту моделювання у секторі безпеки та оборони для українського суспільства.

Дизайн/Метод/Підхід дослідження: основними методами дослідження виступали: пошуково-бібліографічний (з метою систематизації та впорядкування інформаційної основи); системний та предметний аналіз (для уточнення змісту ключових понять з проблеми дослідження); аналіз стану проблеми у Державній прикордонній службі України; аналіз наукової та методичної літератури, словниково-довідникової літератури; аналіз змісту (суттєвих ознак) у визначенні понять “модель” (відображення певного факту, об’єкту та відносини певного середовища у вигляді дещо спрощеного, унаочненого матеріального представлення), “моделювання” (процедура створення певного аналітичного опису щодо вивчення окремих сторін, частин об’єкту у певних взаємозв’язках і відношеннях, що полегшує об’єднання одиничних та загальних елементів), “надзвичайна ситуація” (ситуація, що виступає викликом соціальним уявленням про певний (припустимий) стан справ, цінності, безпеку держави).

Результати дослідження: підтверджено що моделювання є передовий метод оптимізації оперативно-службової діяльності прикордонного загону у мирний та воєнний час, сутність понять моделювання та надзвичайна ситуація.

Теоретична цінність полягає у компіляції популярних наукових поглядів із проблеми дослідження.

Практична цінність визначено особливості моделювання оперативно-службової діяльності прикордонного загону в умовах виникнення ситуації техногенного характеру під час особливого періоду.

Майбутні дослідження: аналіз специфіки імітаційного моделювання у Державній прикордонній службі України.

 Тип статті: теоретична.
The movement games: A methodical approach in the intellectual – motric development of preschoolers
Authors:   Petroleum-Gas University, Bucharest Blvd., no.39, Ploiesti, 100520 Romania, Lupu Elena ,   Kindergarten no.1 Boldești-structure of Secondary School “Mihai Viteazul”, Boldești, Romania,   Extended Day Kindergarten no.2, Filipesti de Padure, Filipesti de Padure, Romania., Alecu Anca ,   Petroleum-Gas University, Bucharest Blvd., no.39, Ploiesti, 100520 Romania; Kindergarten no.1 Boldești-structure of Secondary School “Mihai Viteazul”, Boldești, Romania; Extended Day Kindergarten no.2, Filipesti de Padure, Filipesti de Padure, Romania., Ceascai Mădălina ,   Petroleum-Gas University, Bucharest Blvd., no.39, Ploiesti, 100520 Romania; Kindergarten no.1 Boldești-structure of Secondary School “Mihai Viteazul”, Boldești, Romania; Extended Day Kindergarten no.2, Filipesti de Padure, Filipesti de Padure, Romania.
Published: March 2022

In this study, we aimed to analyze if movement games represent a methodical approach in the intellectual-motric development of pre-schoolers and also if there are significant changes regarding their ability and motric performance. The present theme has been initially introduced as a pilot study and continued up to the present with further analysis on an extended group of subjects. Because of the experiment’s enlargement, the actual study has tracked important differences concerning the pre-schoolers' intellect, their scholarly achievements and exams or test papers. It has been discovered the fact that active scholars, who are involved in movement activities (daily physical education classes) have greater performance at school, whereas the rest (having a single physical education class a week, known as the physical activity moment in the curriculum with a duration of 50 minutes/week) do not. The research was achieved on two groups: A - The pilot group-composed of 12 children (boys and girls); B - The group of fundamental observation made up of 80 children-divided into two groups: An experimental group (E.G.) of 39 children (boys and girls): A control group (C.G.) of other 41 children (boys and girls). Children are aged between 5-6 years old attending the same kindergarten. Findings - During a game and through play, children discover how to learn by adopting a working method that involves activities that follow a step-by-step logical sequence. In conclusion, the movement game is an essential methodical approach in the intellectual-motric growth of pre-schoolers. Used regularly, the movement game will have a positive impact both on the capacity of movement guidance and the intellectual development. Keywords: Lesson, physical education, intellect, schedule, kindergartens.
Rooibos tea (Aspalathus linearis) partially prevents oxidative stress in streptozotocin-induced diabetic rats
Authors: Uličná O , Vančová O , Božek P , Čársky J , Šebeková K , Boor P , Nakano M , Greksák M
Published: March 2022

The aim of this study was to investigate the effects of rooibos tea as a natural source of a wide scale of antioxidants on the prevention and treatment of oxidative stress in streptozotocin-induced diabetic rats. Expected significant changes of biochemical parameters characteristic for experimental diabetic state were found in plasma and tissues eight weeks after single dose streptozotocin application. Administration of aqueous and alkaline extracts of rooibos tea (or N-acetyl-L-cysteine for comparison) to diabetic rats did not affect markers of the diabetic status (glucose, glycated hemoglobin and fructosamine). Besides the parameters characterizing hepatotoxic effect of streptozotocin, rooibos tea significantly lowered advanced glycation end-products (AGEs) and malondialdehyde (MDA) in the plasma and in different tissues of diabetic rats, particularly MDA concentration in the lens. From these results we can conclude that antioxidant compounds in rooibos tea partially prevent oxidative stress and they are effective in both hydrophobic and hydrophilic biological systems. Therefore, rooibos tea as a commonly used beverage can be recommended as an excellent adjuvant support for the prevention and therapy of diabetic vascular complications, particularly for protecting ocular membrane systems against their peroxidation by reactive oxygen species.
Relación entre las barreras para la práctica deportiva y la condición física en adolescentes extremeños desde una perspectiva de género
Authors: Macarro-Sillero Antolín , Carlos-Vivas Jorge , Barrios Fernandez Sabina , Mendoza-Muñoz María , Pastor-Cisneros Raquel , Franco-García Juan Manuel
Published: March 2022

En este trabajo se plantea conocer tanto las barreras para la realización de actividad física (AF) como el nivel de condición física (CF) en adolescentes extremeños y la relación entre ambos, examinando posibles diferencias de género. Se realizó un estudio transversal con 67 adolescentes entre 12 y 15 años. Se administraron un cuestionario sobre barreras para la realización de AF y la batería ALPHA-Fitness para CF. Las adolescentes de género femenino manifestaron tener mayores barreras para la realización de AF en comparación con sus compañeros de género masculino en todos los factores, siendo el factor 4, relacionado con las barreras por incompatibilidad con otras tareas, el que muestra diferencias estadísticamente significativas (p=0.016). Con respecto a la CF, los adolescentes masculinos presentaron un mayor índice de masa corporal (IMC), pero mejores puntuaciones en todas las pruebas de la batería ALPHA-Fitness. Se hallaron diferencias significativas en resistencia (p<0.001), fuerza de prensión en mano izquierda (p=0.003) y salto de longitud (p<0.001) a favor de los chicos. Además, se ha encontrado correlaciones inversas entre las barreras para la práctica de AF y la CF entre los factores 2, 3 y 4 y la CF (p < 0.01) en toda la muestra total. Entre las implicaciones prácticas de estos resultados estaría la necesidad de implementar estrategias con perspectiva de género para superar las barreras para la práctica de AF.
Investigation of the Mechanisms Underlying the Development and Evolution of the Cerebral Cortex Using Gyrencephalic Ferrets
Authors: Shinmyo Yohei , Hamabe-Horiike Toshihide , Saito Kengo , Kawasaki Hiroshi
Published: March 2022

The mammalian cerebral cortex has changed significantly during evolution. As a result of the increase in the number of neurons and glial cells in the cerebral cortex, its size has markedly expanded. Moreover, folds, called gyri and sulci, appeared on its surface, and its neuronal circuits have become much more complicated. Although these changes during evolution are considered to have been crucial for the acquisition of higher brain functions, the mechanisms underlying the development and evolution of the cerebral cortex of mammals are still unclear. This is, at least partially, because it is difficult to investigate these mechanisms using mice only. Therefore, genetic manipulation techniques for the cerebral cortex of gyrencephalic carnivore ferrets were developed recently. Furthermore, gene knockout was achieved in the ferret cerebral cortex using the CRISPR/Cas9 system. These techniques enabled molecular investigations using the ferret cerebral cortex. In this review, we will summarize recent findings regarding the mechanisms underlying the development and evolution of the mammalian cerebral cortex, mainly focusing on research using ferrets.
Unsupervised Mining of HLA-I Peptidomes Reveals New Binding Motifs and Potential False Positives in the Community Database
Authors: Sricharoensuk Chatchapon , Boonchalermvichien Tanupat , Muanwien Phijitra , Somparn Poorichaya , Pisitkun Trairak , Sriswasdi Sira
Published: March 2022

Modern vaccine designs and studies of human leukocyte antigen (HLA)-mediated immune responses rely heavily on the knowledge of HLA allele-specific binding motifs and computational prediction of HLA-peptide binding affinity. Breakthroughs in HLA peptidomics have considerably expanded the databases of natural HLA ligands and enabled detailed characterizations of HLA-peptide binding specificity. However, cautions must be made when analyzing HLA peptidomics data because identified peptides may be contaminants in mass spectrometry or may weakly bind to the HLA molecules. Here, a hybridde novopeptide sequencing approach was applied to large-scale mono-allelic HLA peptidomics datasets to uncover new ligands and refine current knowledge of HLA binding motifs. Up to 12-40% of the peptidomics data were low-binding affinity peptides with an arginine or a lysine at the C-terminus and likely to be tryptic peptide contaminants. Thousands of these peptides have been reported in a community database as legitimate ligands and might be erroneously used for training prediction models. Furthermore, unsupervised clustering of identified ligands revealed additional binding motifs for several HLA class I alleles and effectively isolated outliers that were experimentally confirmed to be false positives. Overall, our findings expanded the knowledge of HLA binding specificity and advocated for more rigorous interpretation of HLA peptidomics data that will ensure the high validity of community HLA ligandome databases.
Hydrogen Permeation Behavior of Carbon Steel During Corrosion in Highly Pressed Saturated Bentonite
Authors: Zhang Qichao , Jiang Yishan , Zhao Xin , Song Penglei , Kuang Tingting , Chen Juna , Sun Zhongtao , Zhang Yaopeng , Ai Xiayu , Lu Dongzhu , Huang Yanliang
Published: March 2022

Deep geological disposal is the most reliable method for high-level nuclear waste, of which metal container as the first barrier for deep geological disposal of high-level nuclear waste is particularly important. Carbon steel is used as a container material because of the low possibility of local corrosion in bentonite. However, after the storage is closed, the decrease of oxygen content will create a near-field environment where the hydrogen embrittlement (HE) in the corrosion process of the container could happen. To evaluate the safety of containers in deep geological disposal of Beshai, the preselected area in China, hydrogen permeation efficiency and HE were estimated in highly pressed saturated bentonite by electrochemical and extrapolation analyses. It is concluded that hydrogen permeation efficiency increases with the disposal year, which proves that the hydrogen evolution reaction dominates the cathode process in the corrosion during long-term disposal. However, slow strain rate tensile shows that Q235 steel has a low HE sensitivity.
The Amplitude of Diaphragm Compound Muscle Action Potential Correlates With Diaphragmatic Excursion on Ultrasound and Pulmonary Function After Supraclavicular Brachial Plexus Block
Authors: Bao Xiuxia , Liu Tao , Feng Haorong , Zhu Yeke , Wu Yingying , Wang Xianghe , Kang Xianhui
Published: March 2022

Objective

This prospective, double-blind, randomized study assessed (1) the associations between diaphragm compound muscle action potential (CMAP), hemidiaphragmatic excursion, and pulmonary function after supraclavicular brachial plexus block (SCBPB) and (2) diagnostic efficacy of pulmonary function for hemidiaphragmatic paralysis evidenced by diaphragm CMAP as an assessment of diaphragm strength was evaluated.

Methods

Eighty-six patients were scheduled for the removal of hardware after healing of a right upper limb fracture distal to the shoulder who were randomly assigned in a 1:1 ratio to two groups: Group A (diaphragmatic excursion), or Group B (pulmonary function). Phrenic nerve conduction studies (PNCSs), M-mode ultrasonography of the diaphragm, and pulmonary function tests (PFTs) were performed before and 30 min after SCBPB. PNCSs were used to determine the latency and amplitude of diaphragm CMAP. Ultrasonography of the diaphragm was performed with patients in a supine position using a low-frequency probe over the subcostal space at the midclavicular line. The diaphragmatic excursion was measured during quiet breathing and deep breathing. Pulmonary function, i.e., forced vital capacity (FVC), predicted value of FVC, and forced expiratory flow in the first second (FEV1), was measured with spirometry. Receiver Operating Characteristic (ROC) curve analysis was used to assess the diagnostic efficacy of pulmonary function for hemidiaphragmatic paralysis evidenced by diaphragm CMAP as an assessment of diaphragm strength.

Results

There were significant associations between the reduction in amplitude of diaphragm CMAP and reductions in diaphragmatic excursion during quiet breathing (r = 0.70, p < 0.01) and deep breathing (r = 0.63, p < 0.01) when expressed as a percentage of baseline values. There were significant associations between the reduction in amplitude of diaphragm CMAP and reductions in FVC (r = 0.67, p < 0.01), FVC% (r = 0.67, p < 0.01), and FEV1 (r = 0.62, p < 0.01), when expressed as percentage of baseline values. The area under the ROC curve for FVC was 0.86. A decrease of >8.4% in FVC compared to pre-block predicted hemidiaphragmatic paralysis (determined by diaphragm CMAP) with sensitivity and specificity of 79.2 and 100%, respectively.

Conclusions

The relative reduction in diaphragm CMAP amplitude after SCBPB was correlated with relative reductions in diaphragmatic excursion and pulmonary function. FVC has potential as a useful diagnostic indicator of hemidiaphragmatic paralysis, evidenced by diaphragm CMAP, after SCBPB. These data establish diaphragm CMAP as a direct and objective index of diaphragmatic paralysis after SCBPB.
Treatment of Trypanosoma evansi-Infected Mice With Eucalyptus camaldulensis Led to a Change in Brain Response and Spleen Immunomodulation
Authors: Dkhil Mohamed A. , Al-Shaebi Esam M. , Abdel-Gaber Rewaida , Alkhudhayri Abdulsalam , Thagfan Felwa A. , Al-Quraishy Saleh
Published: March 2022

Surra is a parasitic disease caused by the eukaryotic, unicellular hemoprotozoan, Trypanosoma evansi, which affects the development of animal production and is widespread among both domestic and wild animals. As such, in this research, we studied the antiparasitic activity and the ameliorative impact of Eucalyptus camaldulensis leaf extracts (ELE) against T. evansi-induced brain injury and spleen immune response in mice. As a result, we found that ELE decreased the amount of trypanosomes in the blood and improved the weight loss caused by infection. In addition, ELE reduced the parasite-induced brain and spleen histopathological damage. The parasite affected the levels of dopamine and serotonin, but after treatment with ELE, their concentrations significantly decreased to 154 ± 7 and 258 ± 11 μg/g, respectively. We clearly observed the antioxidant activity of ELE because of its ability to increase the induced change in the brain’s total antioxidant capacity and the nitric oxide level. The histopathological changes in the spleen also improved after ELE application. Based on our results, we concluded that ELE possesses antitrypanosomal antioxidant and protective effects in the brains of mice infected with T. evansi. Additional phytochemical screening and molecular studies are required to understand the mechanism underlying the effect of ELE.
Immune Subtypes Characterization Identifies Clinical Prognosis, Tumor Microenvironment Infiltration, and Immune Response in Ovarian Cancer
Authors: Lu Weihong , Zhang Fei , Zhong Xiaolin , Wei Jinhua , Xiao Hongyang , Tu Ruiqin
Published: March 2022

Objective: Because of the modest immunotherapeutic response among ovarian carcinoma (OC) patients, it is significant to evaluate antitumor immune response and develop more effective precision immunotherapeutic regimens. Here, this study aimed to determine diverse immune subtypes of OC.

Methods: This study curated the expression profiles of prognostic immunologically relevant genes and conducted consensus clustering analyses for determining immune subtypes among OC patients in TCGA cohort. With Boruta algorithm, characteristic genes were screened for conducting an immune scoring system through principal component analysis algorithm. The single-sample gene set enrichment analysis and ESTIAMTE methods were adopted for quantifying the immune infiltrates and responses to chemotherapeutic agents were estimated with pRRophetic algorithm. Two immunotherapeutic cohorts were used for investigating the efficacy of immune score in predicting therapeutic benefits.

Results: Two immune subtypes were conducted among 377 OC patients. Immune subtype 2 was characterized by worse clinical prognosis, more frequent genetic variations and mutations, enhanced immune infiltrates, and increased expression of MHC molecules and programmed cell death protein 1/programmed death ligand 1 (PD-1/PD-L1). In total, 30 prognosis-relevant characteristic immune subtype–derived genes were identified for constructing the immune score of OC patients. High immune score was linked with more dismal prognosis, decreased immune infiltrations, and expression of MHC molecules. High immune score presented favorable sensitivity to doxorubicin and vinorelbine and reduced sensitivity to cisplatin. In addition, immune score possessed the potential in predicting benefits from anti–PD-1/PD-L1 therapy.

Conclusion: Collectively, our findings propose two complex and diverse immune subtypes of OC. Quantitative assessment of immune subtypes in individual patients strengthens the understanding of tumor microenvironment features and promotes more effective immunotherapeutic regimens.
Automated Pupillometry for Prediction of Electroencephalographic Reactivity in Critically Ill Patients: A Prospective Cohort Study
Authors: Peluso Lorenzo , Ferlini Lorenzo , Talamonti Marta , Ndieugnou Djangang Narcisse , Gouvea Bogossian Elisa , Menozzi Marco , Annoni Filippo , Macchini Elisabetta , Legros Benjamin , Severgnini Paolo , Creteur Jacques , Oddo Mauro , Vincent Jean-Louis , Gaspard Nicolas , Taccone Fabio Silvio
Published: March 2022

Background

Electroencephalography (EEG) is widely used to monitor critically ill patients. However, EEG interpretation requires the presence of an experienced neurophysiologist and is time-consuming. Aim of this study was to evaluate whether parameters derived from an automated pupillometer (AP) might help to assess the degree of cerebral dysfunction in critically ill patients.

Methods

Prospective study conducted in the Department of Intensive Care of Erasme University Hospital in Brussels, Belgium. Pupillary assessments were performed using the AP in three subgroups of patients, concomitantly monitored with continuous EEG: “anoxic brain injury”, “Non-anoxic brain injury” and “other diseases”. An independent neurologist blinded to patient's history and AP results scored the degree of encephalopathy and reactivity on EEG using a standardized scale. The mean value of Neurologic Pupil Index (NPi), pupillary size, constriction rate, constriction and dilation velocity (CV and DV) and latency for both eyes, obtained using the NPi®-200 (Neuroptics, Laguna Hills, CA, USA), were reported.

Results

We included 214 patients (mean age 60 years, 55% male). EEG tracings were categorized as: mild (n = 111, 52%), moderate (n = 65, 30%) or severe (n = 16, 8%) encephalopathy; burst-suppression (n = 19, 9%) or suppression background (n = 3, 1%); a total of 38 (18%) EEG were classified as “unreactive”. We found a significant difference in all pupillometry variables among different EEG categories. Moreover, an unreactive EEG was associated with lower NPi, pupil size, pupillary reactivity, CV and DV and a higher latency than reactive recordings. Low DV (Odds ratio 0.020 [95% confidence intervals 0.002–0.163]; p < 0.01) was independently associated with an unreactive EEG, together with the use of analgesic/sedative drugs and high lactate concentrations. In particular, DV values had an area under the curve (AUC) of 0.86 [0.79–0.92; p < 0.01] to predict the presence of unreactive EEG. In subgroups analyses, AUC of DV to predict unreactive EEG was lower (0.72 [0.56–0.87]; p < 0.01) in anoxic brain injury than Non-anoxic brain injury (0.92 [0.85–1.00]; p < 0.01) and other diseases (0.96 [0.90–1.00]; p < 0.01).

Conclusions

This study suggests that low DV measured by the AP might effectively identify an unreactive EEG background, in particular in critically ill patients without anoxic brain injury.
PTPRM Is Critical for Synapse Formation Regulated by Zinc Ion
Authors: Mo Xiaoqiang , Liu Mengxue , Gong Jihong , Mei Ying , Chen Huidan , Mo Huajun , Yang Xiaofei , Li Jun
Published: March 2022

In the nervous system, the trace metal ion zinc is required for normal mammalian brain development and physiology. Zinc homeostasis is essential for the control of physiological and pathophysiological brain functions. Synapses, the junctions between neurons, are the center of the brain’s information transmission. Zinc deficiency or excess leads to neurological disorders. However, it is still unclear whether and how zinc ion regulates synapse formation. Here, we investigated the effect of zinc on synapse formation in a cultured neuron system, and found that synapse formation and synaptic transmission were regulated by zinc ions. Finally, we identified that PTPRM is the key gene involved in synapse formation regulated by zinc ions. This study provides a new perspective to understanding the regulation of brain function by zinc ion.
Diagnosis of Serosal Invasion in Gastric Adenocarcinoma by Dual-Energy CT Radiomics: Focusing on Localized Gastric Wall and Peritumoral Radiomics Features
Authors: Yang Li , Sun Junyi , Yu Xianbo , Li Yang , Li Min , Liu Jing , Wang Xiangming , Shi Gaofeng
Published: March 2022

Objectives

To build a radiomics model and combined model based on dual-energy CT (DECT) for diagnosing serosal invasion in gastric adenocarcinoma.

Materials and methods

231 gastric adenocarcinoma patients were enrolled and randomly divided into a training (n = 132), testing (n = 58), and independent validation (n = 41) cohort. Radiomics features were extracted from the rectangular ROI of the 120-kV equivalent mixed images and iodine map (IM) images in the venous phase of DECT, which was manually delineated perpendicularly to the gastric wall in the deepest location of tumor infiltration, including the peritumoral adipose tissue within 5 mm outside the serosa. The random forest algorithm was used for radiomics model construction. Traditional features were collected by two radiologists. Univariate and multivariate logistic regression was used to construct the clinical model and combined model. The diagnostic efficacy of the models was evaluated using ROC curve analysis and compared using the Delong’s test. The calibration curves were used to evaluate the calibration performance of the combined model.

Results

Both the radiomics model and combined model showed high efficacy in diagnosing serosal invasion in the training, testing and independent validation cohort, with AUC of 0.90, 0.90, and 0.85 for radiomics model; 0.93, 0.93, and 0.89 for combined model. The combined model outperformed the clinical model (AUC: 0.76, 0.76 and 0.81).

Conclusion

The radiomics model and combined model constructed based on tumoral and peritumoral radiomics features derived from DECT showed high diagnostic efficacy for serosal invasion in gastric adenocarcinoma.
Association Between Drug Treatments and the Incidence of Liver Injury in Hospitalized Patients With COVID-19
Authors: Gao Suyu , Yang Qingqing , Wang Xuanxuan , Hu Wen , Lu Yun , Yang Kun , Jiang Qiaoli , Li Wenjing , Song Haibo , Sun Feng , Cheng Hong
Published: March 2022

The outbreak of coronavirus disease 2019 (COVID-19) has led to the emergence of global health care. In this study, we aimed to explore the association between drug treatments and the incidence of drug-induced liver injury (DILI) in hospitalized patients with COVID-19. A retrospective study was conducted on 5113 COVID-19 patients in Hubei province, among which 395 incurred liver injury. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox proportional hazards models. The results showed that COVID-19 patients who received antibiotics (HR 1.97, 95% CI: 1.55–2.51, p < 0.001), antifungal agents (HR 3.10, 95% CI: 1.93–4.99, p < 0.001) and corticosteroids (HR 2.31, 95% CI: 1.80–2.96, p < 0.001) had a higher risk of DILI compared to non-users. Special attention was given to the use of parenteral nutrition (HR 1.82, 95% CI: 1.31–2.52, p < 0.001) and enteral nutrition (HR 2.71, 95% CI: 1.98–3.71, p < 0.001), which were the risk factors for liver injury. In conclusion, this study suggests that the development of DILI in hospitalized patients with COVID-19 needs to be closely monitored, and the above-mentioned drug treatments may contribute to the risk of DILI.
PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells
Authors: Chinn Amy M. , Salmerón Cristina , Lee Jihyung , Sriram Krishna , Raz Eyal , Insel Paul A.
Published: March 2022

Chronic decreases in the second messenger cyclic AMP (cAMP) occur in numerous settings, but how cells compensate for such decreases is unknown. We have used a unique system—murine dendritic cells (DCs) with a DC-selective depletion of the heterotrimeric GTP binding protein Gαs—to address this issue. These mice spontaneously develop Th2-allergic asthma and their DCs have persistently lower cAMP levels. We found that phosphodiesterase 4B (PDE4B) is the primary phosphodiesterase expressed in DCs and that its expression is preferentially decreased in Gαs-depleted DCs. PDE4B expression is dynamic, falling and rising in a protein kinase A-dependent manner with decreased and increased cAMP concentrations, respectively. Treatment of DCs that drive enhanced Th2 immunity with a PDE4B inhibitor ameliorated DC-induced helper T cell response. We conclude that PDE4B is a homeostatic regulator of cellular cAMP concentrations in DCs and may be a target for treating Th2-allergic asthma and other settings with low cellular cAMP concentrations.