bluuebunny/crossref_metadata_2025 huggingface dataset:
The Dormouse Reintroduction Program in the UK
Authors: White Ian
Published: April 2022

Hazel Dormice have been lost from 17 English Counties over the past 150 years and the population has declined by 51% since the year 2000. The dormouse reintroduction program has been running since 1993 with the aim of restoring dormice to their native range in the UK. In the early years, a single dormouse population was released in a suitable woodland with the hope that it would occupy all available habitats in the release site and then start to disperse into the wider countryside. While this approach did have some successes, it also had some failures. The program was reviewed in 2014 and some amendments were proposed to the original protocol. A key amendment was to identify at least two woodlands at a site, in relatively close proximity, each suitable for a dormouse release and to undertake at least two reintroductions in an area. Further to the dormouse reintroductions, a landscape project would be established to improve connectivity between the woodlands. The longer-term aim is now to facilitate the creation of a dormouse metapopulation in an area rather than just hoping it would happen. This talk discusses the advantages and difficulties of this new approach and its successes and failures.
The Great British Hedgerow Survey
Authors: White Ian , Gimber Megan
Published: April 2022

In 2013, when the dormouse reintroduction protocol was revised, a national hedge survey methodology was available. This survey enabled individual hedge quality to be assessed and from that, it was possible to quantify the quality of landscape links between reintroduction sites. There was an opportunity to build on this survey so that it could be used more widely and have more useful outcomes. The People's Trust for Endangered Species (PTES) acquired the existing data from the national (DEFRA) survey and started to develop a survey methodology that would be compatible with it, be simple to use, provide a report on the existing state of the hedgerow and give management advice on how to maintain the hedgerow in good condition. As part of the survey development, posters were designed. One of these asks: ‘What have hedgerows ever done for us’, to demonstrate the benefit of hedgerows in the landscape. The other shows ‘The hedgerow management cycle’ to highlight the dynamic nature of hedgerow condition. There are two different hedgerow surveys available, each with a slightly different focus and outcomes. Healthy Hedgerows is a rapid hedgerow survey designed for landowners that want to create a hedge management plan. The Great British Hedgerow Survey generates more detailed feedback on hedgerow health and offers management advice. It is particularly suited to volunteer groups. This talk will discuss the development of the surveys and their part in hedgerow protection in the UK in the future.
Genetic assessment of the Forest Dormouse Dryomys nitedula (Pallas, 1773) in Latvia
Authors: Ruņģis Dainis , Gavarāne Inese , Bankovska Linda , Pilāts Valdis , Segliņa Zanda , Pilāte Digna
Published: April 2022

The Latvian population of the Forest Dormouse is small and isolated, situated far from the main distribution range of this species. The population is located in the south-eastern region of Latvia, close to the Belarusian border. Sixty-three nest-boxes were located throughout this distribution area and captured forest dormouse individuals were sampled for genetic analysis. Animal age, sex, and coordinates from place of capture were recorded. DNA was extracted from 120 individuals using the QIAamp DNA Mini Kit (Qiagen, Germany). RAPD-PCR polymorphisms at 65 loci were used to examine the genetic diversity and differentiation of the Forest Dormouse population in Latvia. 89% of loci were polymorphic, average expected heterozygosity over all loci was 0.321, average polymorphism information content (PIC) was 0.246. The program ‘Structure’ was used to perform Bayesian assignment of individuals to a predefined number of clusters. The deltaK method identified that the most likely number of clusters within the Latvian Forest Dormouse population was three. Assignment of individuals to a particular cluster mostly corresponded with the location where the individual was captured. Analysis of molecular variance (AMOVA) indicated that there was significant genetic differentiation between the three clusters with pairwise Phipt (a modification of Fst) values ranging from 0.118 to 0.180.
Protecting local populations of Hazel Dormice (Muscardinus avellanarius) by translocation: a long-term case study from North Rhine-Westphalia (Germany)
Authors: Höcker Lisa , Weiß Katja , Dietz Markus
Published: April 2022

As part of the mitigation measures adopted in the context of preparatory clearcutting for surface mining, Hazel Dormice have been translocated since 2011. The project is situated in the geographical region of Lower Rhine Basin (North Rhine-Westphalia, Germany). To date, Hazel Dormice have been translocated from an old-growth deciduous forest to four other sites. Three release sites are re-cultivation areas which were planted with trees and shrubs roughly 10 to 30 years ago. The other release site is an old-growth deciduous forest with a well-developed understory. Nest boxes were placed in the source forest and checked between April and October. Any dormice that were found were individually marked and released, inside their nest boxes, at the new sites. Two or three additional nest boxes were placed within the surroundings of each translocated box.

Between 2011 and 2018 we translocated 1,840 individuals. We verify the success of translocation by monitoring the release sites in June and September of the first, second, fifth and eighth year after translocation. Additionally, a sample of 200 nest boxes were checked each month between April and October for five years. Finally, we examined groups of nest boxes shortly after translocation to gather information on the translocated animals immediately after release. Individual records reveals that translocation can be a successful conservation measure to secure local populations if their former habitat is damaged.
A new species of the genus Sweltsa Ricker, 1943 (Plecoptera, Chloroperlidae) from Guizhou Province, China
Authors: Rehman Abdur , Huo Qing-Bo , Du Yu-Zhou
Published: April 2022

Sweltsa is a genus of green stoneflies in the family Chloroperlidae and is distributed throughout the Nearctic and East Palaearctic Regions. As they are sensitive to pollutants, they are often used as an indicator species for determining the quality of water bodies. There are around 57 species of this genus worldwide and 11 of those have been identified from China.

A new species of the Alloperlini genus Sweltsa Ricker, 1943, Sweltsa ligula Rehman, Huo & Du sp. n. is described from Kuankuoshui National Natural Reserve, Suiyang County, Guizhou Province, southwest China. This is the first report of the family Chloroperlidae from Guizhou Province. Diagnosis, description of male, female and nymph, illustration of terminalia and similarities with closely-related species are provided and discussed.
Three new species of Apseudomorpha (Crustacea, Tanaidacea) from Jiaozhou Bay, the Yellow Sea, and the South China Sea off coasts of China
Authors: Tzeng You-Wei , Ma Lin , Li Xinzheng
Published: April 2022

Three new species of the crustacean order Tanaidacea are described from the coasts of China. Apseudes spinidigitussp. nov. (family Apseudidae), from the South China Sea, can be distinguished from the most similar species, A. nhatrangensis, by the features of the maxilliped endite, cheliped dactylus, pereopod 1 carpus and propodus, and pleopods basal article. Phoxokalliapseudes shandongensissp. nov. (family Kalliapseudidae), from Jiaozhou Bay and the Yellow Sea, can be differentiated from the most similar species, P. gibbus, by the features of the antennule article 1, pereopods 1 and 6 propodi, and uropod basal article. Swireapseudes planafrontissp. nov. (family Parapseudidae), from Jiaozhou Bay, can be clearly separated from its congeners by its rostrum, antennule article 1, and pereopod 4 dactylus. A morphological key and comparison table of genus Apseudes from the South China Sea, as well as all known species of the genera Phoxokalliapseudes and Swireapseudes are provided.
Baseline Disease Activity Predicts Achievement of cDAPSA Treatment Targets With Apremilast: Phase III Results in DMARD-naïve Patients With Psoriatic Arthritis
Authors: Mease Philip J. , Kavanaugh Arthur , Ogdie Alexis , Wells Alvin F. , Bergman Martin , Gladman Dafna D. , Richter Sven , Teng Lichen , Jardon Shauna , Smolen Josef S.
Published: April 2022

Objective.

The probability of achieving Clinical Disease Activity Index for Psoriatic Arthritis (cDAPSA) treatment targets (remission [REM], low disease activity [LDA]) was evaluated following apremilast monotherapy in disease-modifying antirheumatic drug (DMARD)-naïve patients with psoriatic arthritis (PsA) based on baseline disease activity.

Methods.

This post hoc probability analysis of PALACE 4, a phase III, multicenter, randomized, placebo-controlled study, evaluated shifting across cDAPSA categories from baseline to week 52 and included DMARD-naïve patients receiving apremilast 30 mg BID with available baseline cDAPSA data. Changes in articular/extraarticular manifestations were evaluated in patients with week 52 cDAPSA components. cDAPSA treatment target achievement was assessed in a subgroup with baseline extraarticular PsA manifestations (skin involvement, enthesitis, dactylitis).

Results.

Of 175 apremilast-treated patients in the probability analysis, 66.3% were in high disease activity (HDA) and 31.4% in moderate disease activity (ModDA) at baseline. Approximately twice as many patients in ModDA at baseline reached REM/LDA at week 52 vs those in HDA (61.7% vs 28.2%). Achieving cDAPSA treatment targets was associated with reductions in articular (swollen/tender joints) and extraarticular (skin involvement, enthesitis, dactylitis, functional disability) disease activity. Similar treatment target achievement rates were observed in the subgroup with ≥ 1 extraarticular PsA manifestation (n = 126; ModDA: 66.7%, HDA: 32.2%).

Conclusion.

Apremilast-treated patients with baseline ModDA had higher probability of achieving cDAPSA treatment targets than patients with HDA. Resolution and/or near resolution of articular and/or extraarticular PsA manifestations was achieved by patients in REM/LDA at week 52. Consistent treatment target achievement was observed in patients with 1 or multiple extraarticular manifestations of active PsA.
Mortality Rates in Patients With Ankylosing Spondylitis With and Without Extraarticular Manifestations and Comorbidities: A Retrospective Cohort Study
Authors: Kelty Erin , Ognjenovic Milica , Raymond Warren D. , Inderjeeth Charles A. , Keen Helen I. , Preen David B. , Nossent Johannes C.
Published: April 2022

Objective.

To examine mortality rates in hospitalized patients with ankylosing spondylitis (AS) and the association of extraarticular manifestations (EAMs) and comorbidities with mortality rates.

Methods.

This study was a retrospective, population-based cohort study using linked administrative data from patients with AS who were hospitalized (n = 1791) and patients in a matched comparison group (n = 8955). Mortality data for patients were obtained from the Western Australia Death Register. The presence of EAMs and comorbidities was identified from hospital records. Mortality rates were compared between the 2 groups using Cox proportional hazard models overall and stratified by a history of EAMs, comorbidities, and smoking status.

Results.

Crude mortality rates were significantly higher among patients with AS than among patients in the comparison group (hazard ratio [HR] 1.85, 95% CI 1.62–2.12), with excess mortality in the AS group associated with cardiovascular disease (CVD; HR 5.32, 95% CI 3.84–7.35), cancer (HR 1.68, 95% CI 1.27–2.23), external causes (HR 3.92, 95% CI 2.28–6.77), and infectious diseases (HR 25.92, 95% CI 7.50–89.56). When patients were stratified by history of EAMs, CVD, and smoking, the risk of mortality was elevated in patients both with and without each risk factor. Among patients with AS, histories of CVD (HR 6.33, 95% CI 4.79–8.38), diabetes (HR 2.81, 95% CI 1.99–3.95), smoking (HR 1.49, 95% CI 1.18–1.89), and EAMs (HR 1.62, 95% CI 1.24–2.11) were associated with an increased risk of mortality.

Conclusion.

The presence of comorbidities, EAMs, and smoking contributes to an increased risk of all-cause mortality among patients with AS who are hospitalized compared to patients in the comparison group. These results support the need to prevent or reduce the occurrence of comorbidities and smoking in patients with AS.
Secukinumab in United States Biologic-Naïve Patients With Psoriatic Arthritis: Results From the Randomized, Placebo-Controlled CHOICE Study
Authors: Nguyen Tien , Churchill Melvin , Levin Robert , Valenzuela Guillermo , Merola Joseph F. , Ogdie Alexis , Orbai Ana-Maria , Scher Jose U. , Kavanaugh Arthur , Kianifard Farid , Rollins Chauncy , Calheiros Renato , Chambenoit Olivier
Published: April 2022

Objective

To evaluate secukinumab (SEC) 300 mg and 150 mg vs placebo in a United States–only population of biologic-naïve patients with psoriatic arthritis (PsA).

Methods

CHOICE was a double-blind, randomized controlled trial conducted in the US. Biologic-naïve patients with PsA and psoriasis (PsO) were randomized 2:2:1 to SEC 300 mg (n = 103), SEC 150 mg (n = 103), or placebo (n = 52). The primary objective was to show superiority of SEC 300 mg vs placebo in American College of Rheumatology 20% (ACR20) response at week 16. Additional objectives included the effect of SEC on dactylitis, enthesitis, PsO, and safety.

Results

ACR20 response rates at week 16 were higher with SEC 300 mg than with placebo (51.5% vs 23.1%; odds ratio 3.51 [95% CI 1.65-7.45]; P = 0.001). SEC 300 mg also led to greater ACR50/70 responses and improvements in other variables vs placebo. Responses were generally sustained over time. Patients with inadequate response to SEC 150 mg at weeks 16, 28, or 40 who received dose escalation to 300 mg experienced improved clinical response after uptitration. The most common adverse events were upper respiratory tract infections and diarrhea. No inflammatory bowel disease was reported or new safety signals observed.

Conclusion

SEC 300 mg led to rapid and significant improvements over placebo in symptoms of PsA in this heavier population of US-only, biologic-naïve patients. Findings were consistent with previous studies and suggest that SEC 300 mg is a safe and efficacious first-line biologic treatment for patients with PsA. [ClinicalTrials.gov: NCT02798211]
Whole-Body Macrophage Positron Emission Tomography Imaging for Disease Activity Assessment in Early Rheumatoid Arthritis
Authors: Verweij Nicki J.F. , de Jongh Jerney , Wee Marieke M. ter , Zwezerijnen Gerben J.C. , Yaqub Maqsood , Voskuyl Alexandre E. , Lammertsma Adriaan A. , van Schaardenburg Dirkjan , Boers Maarten , Lems Willem F. , van der Laken Conny J.
Published: April 2022

Objective

To investigate the potential of whole-body positron emission tomography/computed tomography (PET/CT) with a macrophage tracer to image arthritis in patients with early rheumatoid arthritis (RA).

Methods

Thirty-five previously untreated, clinically active patients with early RA underwent whole-body PET/CT scanning with the macrophage tracer (R)-[11C]PK11195 in addition to clinical assessment (Disease Activity Score in 44 joints [DAS44]). Tracer uptake was assessed quantitatively as standardized uptake values (SUVs). In addition, 2 readers blinded to clinical assessment visually scored tracer uptake in joints. Clinical and PET variables were compared using Cohen , linear regression/correlation, and t tests, where appropriate.

Results

All but 1 patient showed enhanced tracer uptake in at least 1 joint. Twelve percent of all joints (171/1470) were visually positive on the PET scan, most frequently the small joints in feet (40%) and hands (37%), followed by wrists (15%). Correlations of visual scores with clinical findings both at patient and joint levels were absent or weak. In contrast, average SUVs in the hands, feet, and whole body showed significant correlations with DAS44 scores, with the best correlation seen in the feet (R2 = 0.29, P < 0.01).

Conclusion

Clinically active patients with early RA had increased joint uptake of a macrophage PET tracer, especially in the feet. Quantitative, but not visual PET measures of whole body and joint groups, particularly the feet, showed moderate and statistically significant correlations with clinical outcome.
Potential Impact of Sex and BMI on Response to Therapy in Psoriatic Arthritis: Post Hoc Analysis of Results From the SEAM-PsA Trial
Authors: Mease Philip J. , Gladman Dafna D. , Merola Joseph F. , Deodhar Atul , Ogdie Alexis , Collier David H. , Liu Lyrica , Kavanaugh Arthur
Published: April 2022

Objective

In this post hoc analysis, we examined the potential impact of sex and BMI on response in the Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects with Psoriatic Arthritis (SEAM-PsA) trial (NCT02376790), a 48-week, phase III, randomized controlled trial that compared outcomes with methotrexate (MTX) monotherapy, etanercept (ETN) monotherapy, and MTX+ETN combination therapy in patients with psoriatic arthritis (PsA) who were naïve to MTX and biologics.

Methods

We evaluated key outcomes at week 24 stratified by sex (male vs female) and BMI (kg/m2; ≤ 30 vs > 30), including the American College of Rheumatology 20 (ACR20) criteria, minimal disease activity (MDA), very low disease activity (VLDA), and Psoriatic Arthritis Disease Activity Score (PASDAS). We analyzed data using descriptive statistics, normal approximation, logistic model, and analysis of covariance.

Results

A total of 851 patients completed the SEAM-PsA trial. Higher proportions of men than women who received MTX+ETN combination therapy achieved ACR20 (71.5% vs 58.3%;P= 0.02), MDA (45.8% vs 25.2%;P= 0.0003), and VLDA (19.1% vs 9.5%;P= 0.03), and men achieved better PASDAS (-3.0 vs -2.3;P= 0.0004). Patients with BMI ≤ 30 generally had better outcomes than those with BMI > 30 in some treatment arms for ACR20, MDA, VLDA, and PASDAS; however, there was no consistent pattern regarding the treatment arm in which the difference occurred.

Conclusion

Improved outcomes were observed more in men than in women for MDA and PASDAS with MTX+ETN combination therapy. Patients with BMI ≤ 30 had better outcomes than those with BMI > 30, with no clear pattern regarding treatment received. These findings suggest that contextual factors such as sex and BMI may affect response to PsA therapy.
Challenges in the Diagnosis and Assessment of Psoriatic Arthritis
Authors: Ogdie Alexis , Lindsay Christine A. , Mease Philip J. , Callis Duffin Kristina , Rosen Cheryl F. , Siebert Stefan
Published: April 2022

Each year, the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) holds a trainee symposium adjacent to the GRAPPA annual meeting. The target audience for this meeting includes trainees in rheumatology, dermatology, and related fields. The 2021 GRAPPA Trainee Symposium focused on challenges in the diagnosis and assessment of psoriatic arthritis (PsA). During the meeting, speakers focused on identification of psoriasis (PsO), the differential diagnosis for both PsO and PsA, diagnostic errors and pitfalls, physical examination in PsA, patient-reported outcomes and composite measures in the assessment of PsA, and the patient perspective on diagnosis and assessment, followed by a panel discussion. This paper summarizes the content discussed at the meeting.
Incidence Rates of Psoriasis in Children With Inflammatory Bowel Disease and Juvenile Arthritis Treated With Tumor Necrosis Factor Inhibitors and Disease-Modifying Antirheumatic Drugs
Authors: Baggett Katelyn , Brandon Timothy G. , Xiao Rui , Valenzuela Zachary , Buckley Lisa H. , Weiss Pamela F.
Published: April 2022

Objective

To estimate the differential effect of tumor necrosis factor inhibitor (TNFi) therapies and presence or absence of conventional synthetic disease-modifying antirheumatic drugs (DMARDs) on the incidence of psoriasis (PsO) in children with inflammatory bowel disease (IBD), juvenile idiopathic arthritis (JIA), and chronic nonbacterial osteomyelitis (CNO).

Methods

This was a retrospective cohort study from 2008 to 2020. TNFi and DMARD exposures were dichotomized as ever/never. The primary outcome was incident PsO. Incidence rates (IRs) of PsO were stratified by underlying diagnosis, TNFi agent, and DMARD use. Poisson regression was used to assess the IR ratios (IRRs) between exposure groups.

Results

There were 5088 children who met the inclusion criteria: 3794 (75%) had IBD, 1189 (23%) had JIA, and 105 (2%) had CNO. Of the 2023 children with TNFi exposure, 613 (30%) and 1410 (70%) were with or without a DMARD, respectively. When controlling for DMARD, sex, and family history of PsO, the IRR of developing PsO in patients exposed to adalimumab (ADA) was 2.70 times higher (95% CI 1.53-4.75; P < 0.001) than those who did not receive any TNFi treatment. IRR was lower, but not significantly different, for patients exposed to infliximab (IFX; IRR 2.34, 95% CI 1.56-3.51; P < 0.001) and etanercept (ETN; IRR 2.21; 95% CI 1.17-4.21; P = 0.006) compared to TNFi-unexposed patients. IRR of TNFi exposure was lower by 0.25 (P < 0.001) in DMARD-exposed patients compared to non–DMARD-exposed patients.

Conclusion

IRR of TNFi-induced PsO was not significantly different among ADA, IFX, and ETN. However, for patients with exposure to any of the TNFi evaluated, the IRR was significantly lower in those also exposed to a DMARD.
Rho Kinase Expression in Giant Cell Arteritis: Validating Phosphorylated Ezrin/Radixin/Moesin Intensity Score to Increase Sensitivity of Temporal Artery Biopsy
Authors: Lally Lindsay , Narula Navneet , Goodfellow Nicola , Luqmani Raashid , Pisapia David , Spiera Robert F.
Published: April 2022

Objective

Aberrant Rho-associated protein kinase (ROCK) activity is implicated in several vascular and immunologic disorders. We previously demonstrated increased ROCK activity in histopathologically negative temporal artery biopsies (TABs) in subjects with clinical giant cell arteritis (GCA) compared to those without GCA. This current study aimed to examine ROCK activity in a larger cohort of biopsy-negative GCA subjects and to validate the prior findings.

Methods.

Based on clinical data 6 months after TAB, subjects were categorized into 2 groups: biopsy-negative GCA and controls without GCA. Paraffin-embedded TABs were stained for phosphorylated ezrin/radixin/ moesin (pERM), a surrogate of ROCK activity, and scored by 2 pathologists blinded to clinical diagnosis using a previously derived scoring system measuring staining intensity in 3 areas of the vessel.

Results.

Thirty-six subjects with biopsy-negative GCA and 43 controls were analyzed. The mean (SD) pERM intensity score in non-GCA subjects was 3.9 (1.4), compared to 5.0 (1.4) in those with GCA (P = 0.002). Using the predetermined cut-off of 4 to define high pERM intensity, subjects with GCA were significantly more likely to have a high pERM intensity score compared to non-GCA (odds ratio 3.67, 95% CI 1.19-11.36; P = 0.02. The sensitivity of high pERM intensity score for diagnosis of GCA in histologically negative TABs was 86% (95% CI 70-95).

Conclusion.

In this well-characterized cohort, those with biopsy-negative GCA had significantly higher pERM intensity scores compared to subjects without GCA. pERM staining has diagnostic significance in enhancing the sensitivity of TAB and may help to define the clinically important group of biopsy-negative GCA.
Gout and Hospital Admission for Ambulatory Care–Sensitive Conditions: Risks and Trajectories
Authors: Kiadaliri Ali , Neogi Tuhina , Englund Martin
Published: April 2022

Objective.

To investigate the risks and trajectories of hospital admission for ambulatory care–sensitive conditions (ACSCs) in gout.

Methods.

Among individuals aged 35 years to 85 years residing in Skåne, Sweden, in 2005, those with no doctor-diagnosed gout during 1998 to 2005 (n = 576,659) were followed from January 1, 2006, until a hospital admission for an ACSC, death, relocation outside Skåne, or December 31, 2016. Treating a new gout diagnosis (International Classification of Diseases, 10th revision, code M10) as a time-varying exposure, we used Cox proportional and additive hazard models to estimate the effects of gout on hospital admissions for ACSCs. We investigated the trajectory of hospital admissions for ACSCs from 3 years before to 3 years after gout diagnosis using generalized estimating equations and group-based trajectory modeling in an age-and sex-matched cohort study.

Results.

Gout was associated with a 41% increased rate of hospital admission for ACSCs (hazard ratio 1.41, 95% CI 1.35-1.47), corresponding to 121 (95% CI 104-138) more hospital admissions for ACSCs per 10,000 person-years compared with those without gout. Our trajectory analysis showed that higher rates of hospital admission for ACSCs among persons with gout were observed from 3 years before to 3 years after diagnosis, with the highest prevalence rate ratio (2.22, 95% CI 1.92-2.53) at the 3-month period after diagnosis. We identified 3 classes with distinct trajectories of hospital admissions for ACSCs among patients with gout: almost none (88.5%), low-rising (9.7%), and moderate-sharply rising (1.8%). The Charlson Comorbidity Index was the most important predictor of trajectory class membership.

Conclusion.

Increased risk of hospital admissions for ACSCs in gout highlights the need for better management of the disease through outpatient care, especially among foreign-born, older patients with comorbidities.
Treatment of rituximab in patients with idiopathic membranous nephropathy: a case series and literature review
Authors: Jeon Soo-Jee , Kim Ji-Hye , Noh Hee-Won , Lee Ga-Young , Lim Jeong-Hoon , Jung Hee-Yeon , Cho Jang-Hee , Choi Ji-Young , Kim Chan-Duck , Kim Yong-Lim , Park Sun-Hee
Published: April 2022

Background/Aims: Membranous nephropathy (MN) is a major cause of nephrotic syndrome in adults. This study aimed to evaluate the effect of rituximab (RTX) in patients with idiopathic MN (iMN) who have a high risk of progression.Methods: We retrospectively analyzed data of 13 patients with iMN, who received RTX treatments from January 2014 to July 2020. RTX was indicated in patients with iMN with severe proteinuria and decreasing estimated glomerular filtration rate (eGFR) in the previous 6 months despite other immunosuppressive therapies.Results: The patients were predominantly males (n = 11) and with a mean age of 55.3 years; median eGFR, 37.0 mL/min/1.73 m2 (interquartile range [IQR], 26.3 to 66.5); serum albumin level, 2.6 g/dL (IQR, 1.9 to 3.1); and spot urine protein-to-creatinine ratio at baseline, 6.6 g/g (IQR, 5.7 to 12.9). In a median follow-up of 22 months, eight patients (61.5%) achieved complete or partial remission. In responder group (n = 8), median eGFR increased from 31.5 to 61.5 mL/min/1.73 m2 (p = 0.049) and serum albumin level increased from 2.3 to 4.2 g/dL (p = 0.017) from RTX initiation to last follow-up. Antiphospholipase A2 receptor antibody (anti-PLA2R-Ab) was positive in six among seven tested patients, which markedly decreased in the responder group. There were no adverse events after RTX.Conclusions: This study suggests that RTX is a safe and effective treatment option for patients with iMN who have a high risk of progression. Individualized therapy based on anti-PLA2R-Ab titer would be needed for better outcomes.
De l’utilité des objets flottants dans le cadre d’un dispositif « groupe fratrie » destiné à des frères et sœurs d’enfants porteurs de troubles du spectre de l’autisme
Authors: Claudel-Valentin Stéphanie , Jehenne Anne-Bérengère , Gagnard Marie-Line , Arnould Delphine
Published: April 2022

Dans une perspective combinant approche systémique et psychodynamique de manière complémentaire, cet article présente une étude portant sur le vécu des frères et sœurs d’enfants porteurs de troubles du spectre de l’autisme. Afin de répondre à leurs besoins spécifiques, un dispositif nommé « groupe fratrie » a été mis en place durant 3 ans dans le cadre d’un Centre Ressources Autisme. Comprenant deux groupes d’âges d’enfants de 5 à 11 ans et d’adolescents âgés de 12 à 17 ans, il a été coanimé par deux psychologues cliniciennes. Au fil des séances et à l’aide de supervisions réalisées dans le cadre d’une recherche action, des objets flottants ont été proposés pour créer une dynamique de groupe et ainsi permettre aux enfants / adolescents d’élaborer et d’exprimer plus aisément leurs émotions et leurs difficultés. Cette étude est ponctuée par une vignette clinique, dans laquelle est décrite la construction, la mise en scène et les répercussions d’un objet flottant adapté à cette population.
Faire « sans » les pulsions ? Remarques sur la postérité kleinienne
Authors: Castel Pierre-Henri
Published: April 2022

Après avoir retracé un certain nombre de vicissitudes sémantiques du terme anglais emotion , de nature à éclairer son fonctionnement dans les théorisations psychanalytiques outre-Manche, je soutiens l’idée qu’il a été mis à contribution dans le courant kleinien et post-kleinien pour conserver un rôle causal dans la vie psychique consciente et inconsciente à la dimension purement affective-qualitative de la pulsion freudienne, en économisant le recours à la dimension économique. Dans cette mesure, et cette mesure seulement, l’introduction d’un concept psychanalytique d’émotion n’est pas inéluctablement vouée à faire le lit d’une théorie dégénérée de l’empathie dans la cure.
Potential Synergy of Lithium and Ketamine in Treatment of Recurrent Major Depression
Authors: Sun Tony , Francois Dimitry
Published: April 2022

Combination pharmacotherapy has proven to be effective in the treatment of major depressive disorder (MDD), particularly when medications from different drug classes are combined. Lithium and ketamine, although typically not prescribed as first-line treatments, have been used individually to augment the effects of antidepressants; however, little is known about the efficacy of combined lithium and ketamine therapy in treating MDD. We present a patient diagnosed as having MDD whose biweekly ketamine infusions augmented with lithium resulted in an improvement of depressive symptoms, leading to a successful discharge following 2.5 months of hospitalization, during which the patient failed to show improvement with both electroconvulsive therapy and trials of multiple classes of antidepressants.

[
Psychiatr Ann
. 2022;52(4):170–172.]
Management of Patients With Obsessive-Compulsive Disorder: Focus on Pharmacotherapy
Authors: Maziero Maria Paula , Macaya Daniela , Shavitt Roseli Gedanke , Diniz Juliana Belo , Miguel Eurípedes C. , Silva Renata Melo Felipe da , Costa Daniel Lucas da Conceição
Published: April 2022

The use of selective serotonin reuptake inhibitors (SSRIs) for the treatment of obsessive-compulsive disorder (OCD) has dramatically changed clinical practice. Indeed, SSRIs are currently considered the first-line pharmacological therapy for OCD. However, randomized controlled trials (RCTs) have demonstrated a limited efficacy of SSRI treatment in OCD, with nearly half of patients experiencing an unsatisfactory outcome. Critically, nonresponse to treatment of OCD is associated with significant morbidity and social disability. In this study, we conducted a narrative review of the literature to describe and reinforce the basic rationale for pharmacological treatment of OCD. Our primary aim is to discuss the most common clinical issues that arise during the treatment of patients with OCD—details that have not been fully covered within the reports of RCTs. To this end, based on the knowledge of clinicians experienced in OCD treatment, here we provide the best evidence regarding pharmacotherapy for OCD and the management of potential clinical situations that may arise therein. The topics explored in this article include the first- and second-line pharmacological treatments for OCD, concepts of response and remission, pharmacological strategies for SSRI-resistant OCD, and management of adverse events.

[
Psychiatr Ann
. 2022;52(4):143–151.]
Obsessive-Compulsive Disorder Treatment Based on Neurocircuits
Authors: Shephard Elizabeth , Stern Emily R. , Miguel Eurípedes C.
Published: April 2022

Psychiatric disorders affect close to 30% of the global population and account for more than 7% of the global burden of disease. To address this problem, new treatment approaches are required that target the heterogeneity of psychiatric conditions and their underlying neurobiological bases. In this article, we use obsessive-compulsive disorder (OCD) as an example to summarize recent conceptual work that has attempted to offer solutions to better understanding heterogeneity and improving effectiveness of psychiatric treatments. Specifically, we highlight hypothetical “clinical profiles” of OCD that are based on neurocognitive alterations (eg, dysregulated fear), which are underpinned by dysfunctions in specific neurocircuits (eg, hyperactive frontolimbic circuit function) and could be ameliorated with neurocircuit-based treatments. While this model of OCD is not yet ready for clinical use, this approach to understanding OCD may be helpful for clinicians in understanding individual patients under their care and the mechanisms involved in different treatments for OCD.

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Psychiatr Ann
. 2022;52(4);152–156.]
Wellposedness of a DNA replication model based on a nucleation-growth process
Authors: Nieto J. , Vásquez M. O.
Published: April 2022

In this paper, we analyze a nonlinear equation modeling the mechanical replication of the DNA molecule based on a Kolmogorov-Jhonson-Mehl-Avrami (KJMA) type model inspired on the mathematical analogy between the DNA replication process and the crystal growth. There are two different regions on the DNA molecule deep into a duplication process, the connected regions where the base pairs have been already duplicated, called eyes or islands and the regions not yet duplicated, called holes. The Cauchy problem associated with this model will be analyzed, where some dependences and nonlinearities on the replication velocity and the origins of replication are introduced.
Sharp subcritical Sobolev inequalities and uniqueness of nonnegative solutions to high-order Lane-Emden equations on $ \mathbb{S}^n $
Authors: Chen Lu , Lu Guozhen , Shen Yansheng
Published: April 2022

In this paper, we are concerned with the uniqueness result for non-negative solutions of the higher-order Lane-Emden equations involving the GJMS operators on \begin{document}$ \mathbb{S}^n $\end{document}. Since the classical moving-plane method based on the Kelvin transform and maximum principle fails in dealing with the high-order elliptic equations in \begin{document}$ \mathbb{S}^n $\end{document}, we first employ the Mobius transform between \begin{document}$ \mathbb{S}^n $\end{document} and \begin{document}$ \mathbb{R}^n $\end{document}, poly-harmonic average and iteration arguments to show that the higher-order Lane-Emden equation on \begin{document}$ \mathbb{S}^n $\end{document} is equivalent to some integral equation in \begin{document}$ \mathbb{R}^n $\end{document}. Then we apply the method of moving plane in integral forms and the symmetry of sphere to obtain the uniqueness of nonnegative solutions to the higher-order Lane-Emden equations with subcritical polynomial growth on \begin{document}$ \mathbb{S}^n $\end{document}. As an application, we also identify the best constants and classify the extremals of the sharp subcritical high-order Sobolev inequalities involving the GJMS operators on \begin{document}$ \mathbb{S}^n $\end{document}. Our results do not seem to be in the literature even for the Lane-Emden equation and sharp subcritical Sobolev inequalities for first order derivatives on \begin{document}$ \mathbb{S}^n $\end{document}.
Design of energy balancing circuit for battery cells connected in series based on modifying the bidirectional CuK converter
Authors: Van Nguyen Chi , Vinh Thuy Nguyen
Published: April 2022

This paper proposes a design of energy balance circuit for two adjacent Lithium-ion battery cells in the cell string based on the modifying of the bidirectional CuK converter principle. This design only uses one MOSFET to transfer energy between two cells in a direction controlled by the first relay, second relay controls the cutting energy balance circuit off the cells when they have the same energy level. The control command sent by the management battery system (BMS) to the energy balance circuit via an RS485 communication protocol controls the direction of transferring energy, the amplitude of the balance current, the frequency and duty of PWM, the PWM signal applied to MOSFET is programmed by a microprocessor PIC18F2685. This design overcomes some disadvantages caused by applying the principle of bidirectional CuK converter to design the energy balancing circuit, these are the need for a multiple level DC source to open MOSFETs and issue of the energy loss on the elements of energy balance circuit. This design is also easy to expand for the battery string with a large number of cells. The energy balance control strategy can be implemented directly by each the energy balance circuit or remotely by BMS using RS485 communication. The experimental results of online optimal energy balance control based on state of charge (SoC) feedback for 07 SAMSUNG 22P battery cells connected in series are presented to prove the efficiency of the energy balance circuit design for two adjacent cells proposed in this paper.
Permutations involving squares in finite fields
Authors: Wu Hai-Liang , Wang Li-Yuan
Published: April 2022

Let $ p $ be an odd prime and let $ \mathbb{F}_p $ be the finite field of $ p $ elements. In 2019, Sun studied some permutations involving squares in $ \mathbb{F}_p $. In this paper, by the theory of local fields we generalize this topic to $ \mathbb{F}_{p^2} $, which gives a partial answer to the question posed by Sun.
A new very simply explicitly invertible approximation for the standard normal cumulative distribution function
Authors: Lipoth Jessica , Tereda Yoseph , Papalexiou Simon Michael , Spiteri Raymond J.
Published: April 2022

This paper proposes a new very simply explicitly invertible function to approximate the standard normal cumulative distribution function (CDF). The new function was fit to the standard normal CDF using both MATLAB's Global Optimization Toolbox and the BARON software package. The results of three separate fits are presented in this paper. Each fit was performed across the range $ 0 \leq z \leq 7 $ and achieved a maximum absolute error (MAE) superior to the best MAE reported for previously published very simply explicitly invertible approximations of the standard normal CDF. The best MAE reported from this study is 2.73e–05, which is nearly a factor of five better than the best MAE reported for other published very simply explicitly invertible approximations.
An investigation on boundary controllability for Sobolev-type neutral evolution equations of fractional order in Banach space
Authors: Ma Yong-Ki , Kumar Kamalendra , Patel Rohit , Shukla Anurag , Nisar Kottakkaran Sooppy , Vijayakumar Velusamy
Published: April 2022

The main focus of this paper is on the boundary controllability of fractional order Sobolev-type neutral evolution equations in Banach space. We show our key results using facts from fractional calculus, semigroup theory, and the fixed point method. Finally, we give an example to illustrate the theory we have established.
Conceptions de la recherche des universitaires de sciences de l’éducation et formes des travaux émergents
Authors: Bart Daniel
Published: April 2022

Partant d’une approche théorique de l’activité scientifique qui insiste sur le processus d’évaluation et de construction par les pairs de la qualité de recherche émergente, cet article vise à cerner les cadres de référence à partir desquels les travaux émergents sont reconnus par les chercheurs de la communauté de recherche en éducation. Pour ce faire, nous nous appuyons sur les résultats d’une enquête par entretiens menée auprès d’enseignants-chercheurs en sciences de l’éducation. Les interviews portaient notamment sur leur conception de la recherche et de ses activités attenantes. L’analyse de contenu des discours recueillis nous permet d’élaborer quatre formes distinctes de « l’émergence » qui se différencient selon des dimensions épistémologiques, organisationnelles, axiologiques et selon les modes privilégiés de formalisation et de communication de ces travaux. En conclusion, nous discutons des enjeux actuels de l’innovation scientifique pour la recherche en éducation.
Nouveaux modèles de formation et enseignement supérieur : l’exemple du tutorat à l’université
Authors: Annoot Emmanuelle
Published: April 2022

En 1998, le tutorat est officialisé dans l’ensemble des universités françaises par un arrêté du Ministère de l’Éducation nationale. Le tutorat d’accompagnement méthodologique et pédagogique s’effectue sur la base du volontariat pour les étudiants et revêt des formes variées. De nombreux travaux ont exposé les apports et les limites du tutorat. Il sera utile d’en exposer les principales conclusions. En 2007, un plan pluri-annuel pour la réussite en licence, intitulé « Plan licence » est lancé. La loi du 10 août 2007 sur les libertés et responsabilités des universités donne aux établissements d’enseignement supérieur une nouvelle mission en matière d’orientation et d’insertion professionnelle. Dans ce cadre institutionnel, la fonction « tutorat » n’est plus exclusivement réservée aux étudiants puisque les enseignants sont sollicités pour l’aide individualisée (notion d’enseignant référent). Cette aide se décline à plusieurs étapes du parcours de l’étudiant (aide à l’orientation, accueil en premier cycle, parcours progressif dans une licence rénovée, aide à l’insertion) par rapport à des finalités définies à partir du niveau de compétences à atteindre par l’étudiant dans la formation (compétences spécifiques aux disciplines et compétences génériques). On pourra tenter une définition actualisée du tutorat étudiant dans les nouvelles dispositions du plan licence. Cet article a donc pour but de montrer comment le plan licence, lancé en décembre 2007, redéfinit la place du tutorat dans les formations universitaires, ce dispositif devenant un élément d’une politique d’établissement visant à favoriser la réussite des étudiants dès la dernière année du lycée. L’auteure s’interrogera sur la place du discours scientifique dans la définition et l’analyse de ces politiques publiques. Elle s’appuiera sur la synthèse d’un ensemble de travaux de recherche élaborés sur le tutorat conduits avec l’Institut national de Recherche pédagogique (1997-2001) puis le C.N.C.R.E. (1998-2000) et sur un programme en cours intitulé « Formation, qualification, emploi » conduit au sein du Grand réseau de recherche « Culture et Société en Normandie ». Enfin, elle posera des questions sur l’analyse des effets de ces politiques au regard des objectifs affichés et précisera, en conclusion, en quoi ce thème fait émerger des thématiques de recherche centrales pour comprendre les mutations récentes de l’université française.
Les classes préparatoires scientifiques T.B. et A.T.S. : des « prépas » mal connues et reconnues
Authors: Fontanini Christine
Published: April 2022

Cet article s’intéresse à deux classes préparatoires scientifiques peu connues et reconnues dans le monde de l’éducation, de la recherche et de la politique : la préparation Technologie et Biologie (T.B.) et A.T.S. Biologie (années préparatoires spéciales pour technicien supérieur). Pourtant, ces préparations existent depuis plus de vingt ans. Notre recherche par questionnaire, en 2008, auprès de 28 élèves de la classe T.B. (15 filles et 13 garçons) de première année et de 31 élèves de la préparation A.T.S. Biologie (16 filles et 15 garçons) de deux lycées toulousains a mis en évidence que ces deux préparations permettent à des élèves, pas suffisamment excellents pour une intégration en classes préparatoires traditionnelles post-baccalauréat, de tenter néanmoins une intégration dans une école d’ingénieurs agronome ou vétérinaire.
Un métier émergent en éducation : l’accompagnateur de jeunes professeurs recrutés dans le contexte d’un établissement formateur
Authors: Jamet Luc
Published: April 2022

Le nouveau schéma de formation des enseignants en France (Décret 19/12/2006) s’articule autour de deux pôles principaux : « une formation qualification » concrétisée par le master et une « formation qualification » certifiée par le concours. Mais la « formation sensibilisation » qui promouvait une approche pédagogique initiale a disparu et est remplacée par une formation professionnalisante des jeunes recrutés, encadrés par des professeurs expérimentés, au sein d’un établissement formateur. C’est un nouvel espace culturel de formation qui ressemble à un laboratoire mental et intime où tout est à construire, à vérifier, d’un point de vue théorique de construction de l’objet, dans les interactions qui peuvent se nouer entre les recrutés et les expérimentés, dans les finalités de la formation.
Matériaux pour une sociologie du travail des agents de la formation
Authors: Frétigné Cédric
Published: April 2022

Qu’apporte de nouveau ou de différent une perspective de sociologie du travail des agents de la formation ? En quoi cette pratique de recherche émergente contribue-t-elle à mieux rendre compte de ce que former veut dire ? Dans une première partie, l’article montre que la sociologie des groupes professionnels, perspective largement dominante, fait clairement l’impasse sur la question du travail proprement dit des professionnels de la formation. Montrant, dans une seconde partie, la valeur ajoutée des quelques travaux conduits dans une perspective de sociologie du travail des agents de la formation, l’article insiste sur l’importance d’interroger les pratiques et de les replacer dans les configurations sociales qui leur donnent sens. Le texte se poursuit par l’établissement d’un programme de recherche où il est notamment notifié la nécessité de poursuivre et d’intensifier les travaux empiriques pour réellement donner corps à cette perspective de sociologie du travail appliquée aux métiers de la formation. La conclusion propose, sous forme de trois brèves notations, de synthétiser les principaux apports de cette orientation.