bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultraviolet B irradiation increases the expression of cornulin and retepin in human skin xenotransplants
Authors: Makino Teruhiko , Mizawa Megumi , Takemoto Keita , Shimizu Tadamichi
Published: January 2024

Cornulin (CRNN) and repetin (RPTN) belong to the fused-type S100 protein family. Although these proteins have been reported to be expressed in the granular layer of the epidermis and are suggested to be associated with barrier formation in the epidermis, the exact function of these proteins remains unclear. The present study examined the effects of UVB irradiation on the CRNN and RPTN expression in human skin xenotransplantation. The expression of CRNN increased in the granular layer of UVB-irradiated skin two days after UVB irradiation in comparison to sham-irradiated skin. Interestingly, CRNN signals were observed not only in the cytoplasm but also in the peripheral region of the granular keratinocytes. In contrast, RPTN was rarely expressed in sham-irradiated skin; however, RPTN signals were markedly increased in the granular layer of UVB-irradiated skin. The number of RPTN-positive keratinocytes on day 2 after UVB irradiation was significantly higher than that in the sham-irradiated skin. Accordingly, the present study demonstrated that CRNN and RPTN are novel proteins whose expression can be increased by UVB irradiation. In addition, we speculate that the role of CRNN and RPTN in barrier formation of the epidermis may differ according to the expression pattern of these proteins in UVB-irradiated skin.
Synchronization networks reflect the contents of visual working memory
Authors: Haque Hamed , Wang Sheng H. , Siebenhühner Felix , Robertson Edwin , Palva J. Matias , Palva Satu
Published: January 2024

Visual working memory (VWM) comprises of distinct short-term storage of sensory information coupled with executive processes. It has remained untested whether long-range synchronization of neuronal oscillations in the human brain would reflect sensory contents of VWM. We used a VWM task in which memorized contents were precisely controlled to test the sensitivity of synchronization to VWM contents using concurrent magneto- and electroencephalography (M/EEG) combined with source-connectivity analysis. We show here that alpha-band phase-synchronization and theta-band desynchronization track VWM contents and correlates with performance. The alpha-band network was found in visual areas corresponding to the memorized features coupled to the fronto-parietal network (FPN) such that key connections of the FPN network were shared across contents. Machine-learning analysis established that only alpha-band networks contained content-information and allowed decoding of VWM contents. Our results establish that alpha-band phase synchronization reflects remembered VWM contents and provides a novel perspective for the organization of VWM.
Stakeholder capitalism as a modern model of corporate social responsibility
Authors: Kytsak Taras , Marshavin Yurii , Vasylenko Andrii , Marshavin Oleg , Hutnitskyi Vitalii
Published: January 2024

The article reveals the conceptual foundations and importance of the stakeholder model for the successful functioning of modern business organizations, their development, ensuring competitive advantages, strengthening sustainability, brand and image growth. The relevance of this concept is also substantiated for ensuring sustainable social development. The purpose of the study is to examine the practical aspects of stakeholder capitalism as a modern model for implementing social responsibility by business organizations. In the course of scientific research into the essence and scope of expression of the modern stakeholder model of business activities, the author's own idea of the practical value of these processes for business and society as a whole was developed. The key potential benefits for business organizations in establishing an effective dialogue with key stakeholders based on social responsibility are identified. The author's own vision of the substantive essence of an effective model of interaction with stakeholders is developed, which will affect the increase in a company’s capitalization, increased sustainability, and increased investment attractiveness. A list of possible areas and directions of interaction between the company and key stakeholders is presented in a reasoned manner. Proposals have been developed for promising areas for the development of the stakeholder model of capitalism, based on the principles of social responsibility in modern conditions.
Peningkatan Kualitas SDM Pengelola Desa dalam Digitalisasi Desa Wisata
Authors:   Politeknik Pariwisata NHI Bandung, Jalan Setiabudi No. 186, Bandung, Indonesia, Rosiana Eka Nuraisah , Maulina Lien ,   Politeknik Pariwisata NHI Bandung, Jalan Setiabudi No. 186, Bandung, Indonesia, Irani Siti Yulia ,   Politeknik Pariwisata NHI Bandung, Jalan Setiabudi No. 186, Bandung, Indonesia, Daniati Hanna ,   Politeknik Pariwisata NHI Bandung, Jalan Setiabudi No. 186, Bandung, Indonesia, Kuswandi Dede ,   Politeknik Pariwisata NHI Bandung, Jalan Setiabudi No. 186, Bandung, Indonesia
Published: January 2024

This study aims to determine the quality of human resources, digitalization of tourist villages, and strategies to improve the quality of human resources in digitalization efforts in the Cikakak Tourism Village. The research was conducted using a qualitative research method, with data collection using structured interviews with the village government, BUMDes, Pokdarwis, Pokja, and tourism managers. The results of this study show that the quality of human resources managing the Cikakak Tourism Village in terms of physical capabilities in the form of health human resources, both village government, BUMDes, Pokdarwis, Pokja, and tourism managers, is quite good. Then to digitize the Cikakak Tourism Village, it utilizes several digital platforms, namely websites, Instagram, and YouTube. However, the use of digital platforms, including websites, Instagram, and YouTube, still has deficiencies in helping tourists buy entrance tickets to tourist attractions, order homestays, culinary delights, and tour packages online. The Cikakak Tourism Village has low quality human resources in digitalization efforts, this can be seen in terms of the number of digital media managers who are still small, the knowledge and ability of human resources in digitizing tourist villages is also still low.
Insight into Fintech Products and Services in India among Generation Z
Authors: Anand Abhijeet , Himani Himani , Gautam Abhishek Kumar , Modi Satish
Published: January 2024

The primary objective of this research is to establish a comprehensive comprehension of the attitudes harbored by Generation Z toward fintech products and services and to identify the influential factors shaping their adoption and utilization patterns. This study endeavors to provide valuable insights regarding the determinants impacting the adoption and usage of fintech within this demographic. To achieve this goal, a descriptive and exploratory research design was employed, drawing upon a sample comprising more than 200 respondents. The study offers an extensive analysis of the market landscape, key industry participants, and emerging trends that are reshaping the fintech sector. The research findings divulge that the variables such as technological compatibility, economic stability, and usage frequency have significant influence over Generation Z’s perception and willingness to embrace fintech. The results accentuate the pivotal role these factors play in shaping the level of acceptance and adoption of fintech technologies among this demographic.
Enabling the uptake of circular water solutions
Authors: Frijns Jos , Smith Heather M. , Makropoulos Christos
Published: January 2024

This study advances the discourse on the transition from a linear to a circular water paradigm, within which water is reused and resources such as nutrients and energy can be recovered. The research provides an empirical evidence from demonstrative cases, identifying the technological, economic, socio-cultural, and regulatory factors that facilitate or impede the broader adoption of circular solutions in the water sector. It proposes an integrated system approach, which encompasses a comprehensive set of enabling instruments, including (a) the demonstration of the sustainability of circular water technologies at a system level, thereby providing a robust proof of concept; (b) a shift from a conventional financial cost-benefit approach to a business model predicated on circular value chains, underscoring the economic feasibility of these solutions; (c) the enhancement of social acceptance through active stakeholder engagement, thereby fostering a supportive community for these transformative changes; and (d) the adaptation of the regulatory framework to incentivise circular water solutions, such as the establishment of dedicated end-of-waste criteria to facilitate market access for recovered resources. The study concludes that a concerted effort is required to reconceptualise our water systems as circular systems, and to legitimise the role of circular water within our society and economy.
Léxico de las bebidas afrodisíacas de la selva peruana: una perspectiva y aproximación lexicográfica
Authors: Reyes Capcha Janeth , Gonzales Jesús Sofía
Published: January 2024

El Perú es un país que se destaca por su diversa gastronomía y arte culinario. Esa misma diversidad se ve reflejada en los nombres de cada plato y bebida, los cuales pueden ser el resultado de la convergencia de costumbres y tradiciones. Mediante el desarrollo del presente estudio se busca realizar una propuesta lexicográfica sobre los nombres de los licores, cocteles y tragos afrodisíacos de la selva peruana y definirlos en correspondencia con los lineamientos del Diccionario de la lengua española (DLE); además, identificar y registrar las categorías gramaticales, así como las marcas diatópicas. Metodológicamente, la investigación es de enfoque cualitativo y de alcance descriptivo. El corpus se constituye por noventa y cinco (95) entradas léxicas. Entre las conclusiones se destaca que los nombres de las bebidas se corresponden, en su mayoría, con procesos de metaforización, pues las palabras que se usan para denominarlas presentan un sentido distinto del significado objetivo; además, que una cantidad significativa proviene del quechua, seguido del castellano. Asimismo, que algunos de los términos no se usan solamente para nombrar a las bebidas, sino que también forman parte de las expresiones cotidianas que suelen utilizarse en ámbitos amicales y familiares, las cuales favorecen la construcción y el fortalecimiento de la identidad regional de los habitantes de Iquitos.
Exploration of Key Genes Combining with Immune Infiltration Level and
Tumor Mutational Burden in Hepatocellular Carcinoma
Authors: Chen Jing , Zhang Lu , Lu Cui-Hua , Xu Chen-Zhou
Published: January 2024

Background:

Hepatocellular carcinoma (HCC) is a lethal malignancy due to its heterogeneity and
aggressive behavior. Recently, somatic mutations and tumor cell interactions with the surrounding tumor
immune microenvironment (TIME) have been reported to participate in HCC carcinogenesis and predict
HCC progression. In this study, we aimed to investigate the association between tumor mutational burden
(TMB) and TIME in HCC. Additionally, we sought to identify differentially expressed genes (DEGs) associated
with HCC prognosis and progression.

Methods:

The expression, clinical, and mutational data were downloaded from the cancer genome atlas
(TCGA) database. The immune infiltration levels and TMB levels of the HCC samples were estimated and
the samples were divided into immune cluster (ICR)-1 and 2 based on immune infiltration score and high and
low TMB groups based on TMB score. Thereafter, differential gene expression analysis was conducted to
identify the DEGs in the ICR1/2 and high/low TMB groups, and the intersecting DEGs were selected. Thereafter,
Cox regression analysis was performed on 89 significant DEGs, among which 19 were associated with
prognosis. These 19 DEGs were then used to construct a prognostic model based on their expression levels
and regression coefficients. Thereafter, we analyzed the DEGs in mutant and wildtype TP53 HCC samples
and identified high BCL10 and TRAF3 expression in the mutant TP53 samples. BCL10 and TRAF3 expression
was detected by real-time quantitative reverse transcription PCR and immunohistochemistry, and their
clinical correlation, biological function, and immune infiltration levels were analyzed by chi-square analyses,
Gene Set Enrichment Analysis (GSEA), and “ssGSEA”, respectively.

Results:

The results of our study revealed that immune infiltration level was correlated with TMB and that
they synergistically predicted poor prognosis of HCC patients. DEGs enriched in immune-related pathways
could serve as indicators of immunotherapy response in HCC. Among these DEGs, BCL10 and TRAF3 were
highly expressed in HCC tissues, especially in the mutant TP53 group, and they co-operatively exhibited
immunological function, thereby affecting HCC progression and prognosis.

Conclusion:

In this study, we identified BCL10 and TRAF3 as potential prognostic indicators in HCC patients.
Additionally, we found that BCL10 and TRAF3 influence TMB and TIME in HCC patients and can be
used for the development of immune-based therapies for improving the long-term survival of HCC patients.
Simultaneous Determination of Levo-tetrahydropalmatine and Naltrexone
in Rat Plasma by LC-MS/MS and its Application in a Pharmacokinetic
Study
Authors: Feng Kun , Sy Sherwin K. B. , Yu Mingming , Lv Zhihua , Yan Meixing
Published: January 2024

Background:

Levo-tetrahydropalmatine and low-dose naltrexone are used in association
with reducing cocaine-related cravings, but there are no analytical methods for the quantitative
simultaneous analysis of this drug combination.

Objective:

A highly selective and sensitive LC-MS/MS assay was developed and validated to
simultaneously quantify l-THP and naltrexone. The analytical method for l-THP offers improved
sensitivity compared to previously published methods.

Methods:

The product ion transitions of l-THP and naltrexone were 357.0→193.0 and
342.2→324.1, respectively. Chromatographic separations were performed using a BEH-C18
column by an isocratic elution mode with acetonitrile and 0.1% formic acid in water containing 3
mM ammonium acetate. L-THP and naltrexone were extracted from rat plasma using a liquidliquid
extraction method.

Results:

For l-THP and naltrexone, the assay displayed good linear response over a concentration
range of 0.5-1000 ng/mL and 0.25-500 ng/mL, respectively. The intra-day accuracy of the
method for l-THP and naltrexone was 93.8-101% with a precision (%CV) of 2.43-8.15% and
93.4-108% with a precision of 3.47-8.22%. The inter-day accuracy for l-THP and naltrexone was
91.2-102% with a CV of 2.46–8.06% and 91.5–97.8% with a CV of 3.29–8.92%, respectively.

Conclusion:

The assay has been used for pharmacokinetic studies of l-THP and naltrexone in the rat.
Targeting Protein Phosphatases for the Treatment of Chronic Liver
Disease
Authors: Li Yi-Ming , He Hong-Wei , Zhang Na
Published: January 2024

There exists a huge number of patients suffering from chronic liver disease worldwide.
As a disease with high incidence and mortality worldwide, strengthening the research on the pathogenesis
of chronic liver disease and the development of novel drugs is an important issue related
to the health of all human beings. Phosphorylation modification of proteins plays a crucial role in
cellular signal transduction, and phosphatases are involved in the development of liver diseases.
Therefore, this article summarized the important role of protein phosphatases in chronic liver disease
with the aim of facilitating the development of drugs targeting protein phosphatases for the
treatment of chronic liver disease.
Cytokines and Regulating Epithelial Cell Division
Authors: Abdullah Marzoog Basheer
Published: January 2024

Physiologically, cytokines play an extremely important role in maintaining cellular and
subcellular homeostasis, as they interact almost with every cell in the organism. Therefore, cytokines
play a significantly critical role in the field of pathogenic pharmacological therapy of different
types of pathologies. Cytokine is a large family containing many subfamilies and can be
evaluated into groups according to their action on epithelial cell proliferation; stimulatory include
transforming growth factor-α (TGF-α), Interlukine-22 (IL-22), IL-13, IL-6, IL-1RA and IL-17 and
inhibitory include IL-1α, interferon type I (IFN type I), and TGF-β. The balance between stimulatory
and inhibitory cytokines is essential for maintaining normal epithelial cell turnover and tissue
homeostasis. Dysregulation of cytokine production can contribute to various pathological conditions,
including inflammatory disorders, tissue damage, and cancer. Several cytokines have shown
the ability to affect programmed cell death (apoptosis) and the capability to suppress non-purpose
cell proliferation. Clinically, understanding the role of cytokines' role in epithelial tissue is crucial
for evaluating a novel therapeutic target that can be of use as a new tactic in the management of
carcinomas and tissue healing capacity. The review provides a comprehensive and up-to-date synthesis
of current knowledge regarding the multifaceted effects of cytokines on epithelial cell proliferation,
with a particular emphasis on the intestinal epithelium. Also, the paper will highlight the
diverse signaling pathways activated by cytokines and their downstream consequences on epithelial
cell division. It will also explore the potential therapeutic implications of targeting cytokine-
epithelial cell interactions in the context of various diseases.
A Review on the Recent Advancements and Artificial Intelligence in
Tablet Technology
Authors: Sahu Amit , Rathee Sunny , Saraf Shivani , Jain Sanjay K.
Published: January 2024

Background::

Tablet formulation could be revolutionized by the integration of modern
technology and established pharmaceutical sciences. The pharmaceutical sector can develop tablet
formulations that are not only more efficient and stable but also patient-friendly by utilizing artificial
intelligence (AI), machine learning (ML), and materials science.

Objectives::

The primary objective of this review is to explore the advancements in tablet technology,
focusing on the integration of modern technologies like artificial intelligence (AI), machine
learning (ML), and materials science to enhance the efficiency, cost-effectiveness, and quality of
tablet formulation processes.

Methods::

This review delves into the utilization of AI and ML techniques within pharmaceutical
research and development. The review also discusses various ML methodologies employed, including
artificial neural networks, an ensemble of regression trees, support vector machines, and
multivariate data analysis techniques.

Results::

Recent studies showcased in this review demonstrate the feasibility and effectiveness of
ML approaches in pharmaceutical research. The application of AI and ML in pharmaceutical research
has shown promising results, offering a potential avenue for significant improvements in
the product development process.

Conclusion::

The integration of nanotechnology, AI, ML, and materials science with traditional
pharmaceutical sciences presents a remarkable opportunity for enhancing tablet formulation processes.
This review collectively underscores the transformative role that AI and ML can play in advancing
pharmaceutical research and development, ultimately leading to more efficient, reliable
and patient-centric tablet formulations.
Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in
Rats with Alzheimer’s Disease: An Experimental and Bioinformatics
Study
Authors: Ma Wei , Lu Kui , Liang Hua-Min , Zhang Jin-Yuan
Published: January 2024

Background:::

Alzheimer’s disease (AD) is a persistent neuropathological injury that
manifests via neuronal/synaptic death, age spot development, tau hyperphosphorylation, neuroinflammation,
and apoptosis. Synapsin 1 (SYN1), a neuronal phosphoprotein, is believed to be responsible
for the pathology of AD.

Objective::

This study aimed to elucidate the exact role of SYN1 in ameliorating AD and its potential
regulatory mechanisms.

Methods::

The AD dataset GSE48350 was downloaded from the GEO database, and SYN1 was focused
on differential expression analysis and Gene Ontology (GO) and Kyoto Encyclopedia of
Genes and Genomes (KEGG) enrichment analyses. After establishing an AD rat model, they were
treated with RNAi lentivirus to trigger SYN1 overexpression. The amelioration of SYN1 in AD-associated
behavior was validated using multiple experiments (water maze test and object recognition
test). SYN1’s repairing effect on the important factors in AD was confirmed by detecting the
concentration of inflammatory factors (interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α),
neurotransmitters (acetylcholine (ACh), dopamine (DA), and 5-hydroxytryptophan (5-HT)) and
markers of oxidative stress (glutathione (GSH), malondialdehyde (MDA), reactive oxygen species
(ROS)). Molecular biology experiments (qRT-PCR and western blot) were performed to examine
AD-related signaling pathways after SYN1 overexpression.

Results::

Differential expression analysis yielded a total of 545 differentially expressed genes, of
which four were upregulated and 541 were downregulated. The enriched pathways were basically
focused on synaptic functions, and the analysis of the protein– protein interaction network focused
on the key genes in SYN1. SYN1 significantly improved the spatial learning and memory abilities
of AD rats. This enhancement was reflected in the reduced escape latency of the rats in the water
maze, the significantly extended dwell time in the third quadrant, and the increased number of
crossings. Furthermore, the results of the object recognition test revealed reduced time for rats to
explore familiar and new objects. After SYN1 overexpression, the cAMP signaling pathway was
activated, the phosphorylation levels of the CREB and PKA proteins were elevated, and the secretion
of neurotransmitters such as ACh, DA, and 5-HT was promoted. Furthermore, oxidative
stress was suppressed, as supported by decreased levels of MDA and ROS. Regarding inflammatory
factors, the levels of IL-6, IL-1β, and TNF-α were significantly reduced in AD rats with SYN1
overexpression.

Conclusion::

SYN1 overexpression improves cognitive function and promotes the release of various
neurotransmitters in AD rats by inhibiting oxidative stress and inflammatory responses
through cAMP signaling pathway activation. These findings may provide a theoretical basis for
the targeted diagnosis and treatment of AD.
Investigating the Influence of Gut Microbiota-related Metabolites in
Gastrointestinal Cancer
Authors: Marzhoseyni Zeynab , Shaghaghi Zahra , Alvandi Maryam , Shirvani Maria
Published: January 2024

Gastrointestinal (GI) cancer is a major health concern due to its prevalence, impact on
well-being, high mortality rate, economic burden, and potential for prevention and early detection.
GI cancer research has made remarkable strides in understanding biology, risk factors, and treatment
options. An emerging area of research is the gut microbiome's role in GI cancer development
and treatment response. The gut microbiome, vital for digestion, metabolism, and immune
function, is increasingly linked to GI cancers. Dysbiosis and alterations in gut microbe composition
may contribute to cancer development. Scientists study how specific bacteria or microbial
metabolites influence cancer progression and treatment response. Modulating the gut microbiota
shows promise in enhancing treatment efficacy and preventing GI cancers. Gut microbiota dysbiosis
can impact GI cancer through inflammation, metabolite production, genotoxicity, and immune
modulation. Microbes produce metabolites like short-chain fatty acids, bile acids, and secondary
metabolites. These affect host cells, influencing processes like cell proliferation, apoptosis, DNA
damage, and immune regulation, all implicated in cancer development. This review explores the
latest research on gut microbiota metabolites and their molecular mechanisms in GI cancers. The
hope is that this attempt will help in conducting other relevant research to unravel the precise
mechanism involved, identify microbial signatures associated with GI cancer, and develop targets.
Synthesis of Some Novel 4-bromobenzoic Acid Clubbed Hydrazone Schiff Base Derivatives as Potent α-amylase Inhibitors: In vitro and In silico Studies
Authors: Khan Momin , Alam Faima , Alam Aftab , Wadood Abdul , Shams Sulaiman , Ali Mahboob , Shah Sana , AlAsmari Abdullah F. , Alharbi Metab , Alasmari Fawaz
Published: January 2024

Aims:

Synthesis of novel 4-bromobenzoic acid-based hydrazone-Schiff base derivatives
and to screen them for their α-amylase inhibitory activity.

Objective:

The biological activities of hydrazone-Schiff base compounds encouraged us to evaluate
the synthesized derivatives (4-32) for in-vitro inhibition activity against the α-amylase enzyme.

Methods:

In current research work twenty-nine Schiff base derivatives (4-32) of 4-bromobenzoic
acid were synthesized in worthy yields by treating various replaced aldehydes with 4-
bromobenzohydrazide using methanol solvent in catalytic quantity of acetic acid. The products
were structurally described through the support of several spectroscopic methods (EI-MS and 1HNMR)
and finally evaluated against α-amylase enzyme.

Results:

All the made derivatives exhibited worthy inhibition potential from IC50 = 0.21 ± 0.01 to
5.50 ± 0.01 μM when equated to the usual acarbose drug having IC50 = 1.34 ± 0.01 μM. Compound
21 (IC50 = 0.21 ± 0.01 μM) was established as the most active inhibitor among the series
better than standard. The structure-activity relationship study showed that the alteration in the activity
of the produced products might be due to the attached position and nature of the substituents.
Furthermore, in-silico study supported the effects of groups attached on the binding interaction
with α-amylase enzyme.

Conclusion:

A series of substituted hydrazone Schiff bases based on 4-bromobenzoic acid were
produced, confirmed the structures by EI-MS and 1H-NMR spectroscopic methods and lastly tested
for their in-vitro α-amylase inhibitory potential. Among the series, twenty-four products indicated
brilliant inhibition potential having IC50 values from 0.21 ± 0.01 to 1.30 ± 0.01 μM. The
structure-activity relationship study showed that the alteration in the activity of the synthesized
products might be due to the attached position and nature of the substituents. On the other hand, in
silico studies advocated that the synthesized Schiff base derivatives have prevalent interactions of
binding within the active site of the α-amylase enzyme, and because of their various attached substituent,
their conformation is altered in the active site of the enzyme. The current study recognized
a number of lead candidates derived from 4-bromobenzoic acid. Additional investigation of the
synthesized derivatives for coming research to get novel α-amylase inhibitors.
Is there an Association between Complementary and Alternative Medicine
use and Trust in Physicians in Patients with Rheumatic Diseases?
Authors: Aharrane Fatima Zahra , Taik Fatima Zahrae , Takhrifa Nihad , Bensaid Rajaa , Soba Nabil , Fourtassi Maryam , Abourazzak Fatima Ezzahra
Published: January 2024

Introduction:

Generally, patients with chronic rheumatic diseases use complementary
and alternative medicine (CAM) in addition to their conventional treatments to manage their
health. Discussing these treatments with their physician is still rare, which might be directly related
to patients’ trust toward them.

Aim:

The primary objective of this study was to assess the association between patients’ trust in
their physician and the use of complementary and alternative medicine among patients with chronic
inflammatory rheumatic diseases. As secondary objectives, to estimate the prevalence of CAM
use, and to identify the associated factors with their use and with trust in physicians.

Methods:

This is a cross-sectional study, which included patients with established chronic inflammatory
rheumatic diseases, at the University Hospital Center in Tangier. The questionnaire included
demographic and clinical information, use of conventional therapy, complementary and alternative
therapy, as well as interpersonal trust in patient-physician relationships using the Trust in
Physician Scale (TPS). A regression analysis was conducted to identify factors associated with
CAM use and with trust in physicians.

Results:

The study included 189 patients. 57.14% of patients reported using complementary
medicine at least once, most patients were women (77.78%), mean age was 46.67 ± 13.25 years
with an average course of the disease of 11.11 ± 9.23 years. The most frequently used CAM treatments
were cupping therapy, massage and the ingestion of a mixture of plants. Mean ± SD Trust
in Physician Scale was 47.64 ± 7.2. There was no significant difference between CAM users vs.
non-users (48.08 ± 6.9 vs 47.04 ± 7.4; p = 0.35). In uni and multivariate analysis, a low level of education
was significantly associated with the use of CAM. However, no statistically significant difference
was found with trust in physicians (OR = 1.020, 95% CI (0.978-1.063), p = 0.354).

Conclusion:

CAM therapy is common in patients with chronic inflammatory rheumatic diseases.
No statistically significant association was found with trust in physicians, it was rather observed
with level of education.
Intrathecal Baclofen Infusion-Botulinum Toxin Combined Treatment
Efficacy in the Management of Spasticity due to Cerebral Palsy
Authors: Marvulli Riccardo , Lagioia Giuseppa , Ianieri Giancarlo , Dell'Olio Lucrezia , Zonno Alessandra , Riccardi Mariagrazia , Sinisi Rosa Bianca , Rizzo Laura Belinda , Farì Giacomo , Megna Marisa , Ranieri Maurizio
Published: January 2024

Background:

Cerebral Palsy (CP) is a group of permanent, but not unchanging, disorders
of movement and/or posture and motor function, which are due to a non-progressive interference, lesion,
or abnormality of the developing/immature brain. One clinical presentation is muscle spasticity,
which leads to a significant impact on the individual’s functionality and quality of life. Spasticity
treatment is multidisciplinary and includes pharmacological and physical intervention; intrathecal
baclofen shows a positive effect in severe spasticity and suboptimal response to oral drugs, while local
injection of Botulinum toxin type A (BTXA) improves muscle tone, motion and pain.

Objective:

The aim of this study was to evaluate the efficacy of the combined intrathecal baclofen
infusion (ITB) - botulinum toxin treatment in the management of spasticity in CP.

Methods:

8 patients with spastic tetraparesis were enrolled. All patients were treated with intrathecal
Baclofen; in lower limbs, no spastic symptoms appeared, while marked spasticity was noted in upper
limbs. We injected the right and left Biceps Brachial (BB) and Flexor Digitorum Superficialis (FDS)
muscles with botulinum toxin type A. All patients underwent Myometric measurement, Ashworth
Scale, Numerical Rating Scale, and Visual Analogic Scale evaluation before infiltration (T0), 30
days after injection (T1), 60 days after injection (T2), and 90 days after treatment (T3).

Results:

All data demonstrated an improvement in spasticity, pain, quality of life, and self-care during
the study, with p < 0.05. No side effects appeared.

Conclusion:

This study demonstrated the efficacy and safety of intrathecal baclofen infusion and
botulinum toxin combined treatment in the management of spasticity, pain, quality of life, and selfcare
in CP patients.
Nanostructured Lipid Carrier-loaded In Situ Gel for Ophthalmic Drug Delivery: Preparation and In Vitro Characterization Studies
Authors: Sabale Vidya , Belokar Vaishnavi , Jiwankar Manasi , Sabale Prafulla
Published: January 2024

Background:

Nanostructured lipid carriers (NLCs) are explored as vehicles for ophthalmic
drug delivery owing to their better drug loading, good permeation, and satisfactory safety profile.

Objective:

The purpose of the study was to fabricate and characterize an in situ ocular gel of loratadine
as a model drug based on NLCs to enhance the drug residence time.

Methods:

NLCs were fabricated using the microemulsion method in which solid lipid as Compritol
888 ATO, lipid as oleic acid, surfactant as Tween 80, and isopropyl alcohol as co-surfactant as alcohol
were used. Based on the evaluation of formulation batches of NLCs, the optimized batch was selected
and further utilized for the formulation of in situ gel containing Carbopol 934 and HPMC
K15M as gelling agents, and characterized.

Results:

The optimized NLCs of loratadine exhibited entrapment efficiency of 83.13 ± 0.13% and an
average particle size of 18.98 ± 1.22 nm. Drug content and drug release were found to be 98.67 and
92.48%, respectively. Excellent rheology and mucoadhesion were demonstrated by the loratadine
NLC-loaded in situ gel to enhance its attachment to the mucosa. NLC-based in situ ocular gel showed
the desired results for topical administration. The prepared gel was observed to be non-irritating to
the eye.

Conclusion:

The optimized NLC-based in situ gel formulation presented better corneal retention and
it was found to be stable, offering sustained release of the drug. Thus, the joined system of sol-gel
was found promising for ophthalmic drug delivery.
Exploring code-switching and code-mixing dynamics in Sundanese-Indonesian bilingual aphasia
Authors: Nasrullah Riki , Lukman Fahmy , Parmin Parmin
Published: January 2024

This research explores the intricate phenomenon of code-switching and code-mixing within the realm of bilingual aphasia patients who converse in both Sundanese and Indonesian. This research is essential to understanding the code-switching and code-mixing phenomenon to improve rehabilitation and effective communication for these patients. Employing a descriptive-qualitative methodology, this study aims to shed light on the language dynamics exhibited by these individuals. To this end, data were meticulously gathered through participant observation in everyday communication, supplemented by in-depth interviews conducted with family members and language therapists. The findings from meticulous data analysis illuminate that aphasia patients fluently alternate between Sundanese and Indonesian, frequently engaging in code-switching and code-mixing when grappling with linguistic expression or comprehension difficulties. Furthermore, this language phenomenon manifests in the patients' inclination toward employing shorter and simpler sentence structures. Consequently, these results underscore the importance of accounting for language selection, code-switching, and code-mixing within the language therapy process for Sundanese-Indonesian bilingual aphasia patients. Language therapists are urged to comprehend and adapt to the patients' flexible language utilization while devising tailored therapeutic strategies to enhance their linguistic proficiency. Moreover, this research calls for future investigations to explore this captivating phenomenon across diverse cohorts of bilingual aphasia patients, thus broadening our understanding of the intricacies involved.
Assessing EFL Papuan students’ ability in memorizing English vocabulary using context clues strategy
Authors: Gultom Monika
Published: January 2024

Research on how to utilize students’ ability to master the foreign language especially in memorizing some words in a target language is believed very important. The purpose of the study is to assess the ability of native Papuans in memorizing some English vocabulary using the keyword system strategy of a selected translated Sentani folktale, entitled The Legend of Sentani Lake. Data was obtained from around 32 students who were asked to memorize several target words. The result showed that students’ keyword system strategy was useful in connecting the spelling, pronunciation, and new words to their prior knowledge by looking at the similarity between the target word and keyword in sound using the key-word system strategy. It is also showed that Papuan EFL students have a high ability to utilize existing knowledge and memorable relationship to memorize new or currently studied English vocabulary. The findings provide important insight for foreign language teaching and learning regarding the importance of encouraging students to develop their ability to master the language being learned by connecting it with something close to the context of Papuan native students’ live in order to make it more effective and meaningful.
Diseño de un sistema para la producción de planchas biodegradables a base de la tusa de maíz (Zea mays)
Authors: Jácome Walter , Moreira Mercedes , Mancheno Edison , Ullón Ariel , Rodríguez Daniel
Published: January 2024

En este artículo se propone una solución constructiva de materiales aislantes a partir de partículas de biomasa de residuos agrícolas, considerando el aglomerado de mazorca de maíz. Mediante pruebas experimentales, se determinó la cantidad de materia prima, densidades, resistencias y como factor de interés, el tiempo de secado, actividades del proceso productivo, diagrama de flujo, recursos humanos y equipos necesarios para llevar a cabo el proceso. Este trabajo tiende a la innovación, a la reducción del impacto ambiental y al aprovechamiento de la mazorca de maíz como materia prima para la obtención de un nuevo producto. La investigación adopta un enfoque exploratorio y descriptivo para evaluar la factibilidad de mitigar el impacto ambiental causado por la quema de la mazorca de maíz en el campo. Este estudio se centra en el desarrollo de láminas comprimidas biodegradables utilizando rastrojo de maíz como materia prima. El objetivo es determinar si el uso de estas láminas puede reducir el impacto medioambiental de la quema en el campo.
Además, este proyecto de investigación se presenta como una iniciativa innovadora que utiliza de forma integral los recursos disponibles en el sector agrícola. En este contexto, buscamos alinear esta propuesta con los principios de producción más limpia y sostenibilidad ambiental. El método utilizado es un diseño descriptivo no empírico combinado con un estudio cualitativo. El estudio pretende evaluar la conciencia cultural y ecológica del consumidor a la hora de comprar láminas ecológicas biodegradables comprimidas de base biológica.
Palabras clave: Aglomerado, mazorca de maíz, proceso, biomasa natural, medio ambiente.
Privacy Concerns About Sharing General and Specific Health Information on Twitter: Quantitative Study
Authors: Esmaeilzadeh Pouyan
Published: January 2024

Background

Twitter is a common platform for people to share opinions, discuss health-related topics, and engage in conversations with a wide audience. Twitter users frequently share health information related to chronic diseases, mental health, and general wellness topics. However, sharing health information on Twitter raises privacy concerns as it involves sharing personal and sensitive data on a web-based platform.

Objective

This study aims to adopt an interactive approach and develop a model consisting of privacy concerns related to web-based vendors and web-based peers. The research model integrates the 4 dimensions of concern for information privacy that express concerns related to the practices of companies and the 4 dimensions of peer privacy concern that reflect concerns related to web-based interactions with peers. This study examined how this interaction may affect individuals’ information-sharing behavior on Twitter.

Methods

Data were collected from 329 Twitter users in the United States using a web-based survey.

Results

Results suggest that privacy concerns related to company practices might not significantly influence the sharing of general health information, such as details about hospitals and medications. However, privacy concerns related to companies and third parties can negatively shape the disclosure of specific health information, such as personal medical issues (β=−.43; P<.001). Findings show that peer-related privacy concerns significantly predict sharing patterns associated with general (β=−.38; P<.001) and specific health information (β=−.72; P<.001). In addition, results suggest that people may disclose more general health information than specific health information owing to peer-related privacy concerns (t165=4.72; P<.001). The model explains 41% of the variance in general health information disclosure and 67% in specific health information sharing on Twitter.

Conclusions

The results can contribute to privacy research and propose some practical implications. The findings provide insights for developers, policy makers, and health communication professionals about mitigating privacy concerns in web-based health information sharing. It particularly underlines the importance of addressing peer-related privacy concerns. The study underscores the need to build a secure and trustworthy web-based environment, emphasizing the significance of peer interactions and highlighting the need for improved regulations, clear data handling policies, and users’ control over their own data.
Web-Based Health Information Seeking by People Living With Multiple Sclerosis: Qualitative Investigation of the Multiple Sclerosis Online Course
Authors: Bevens William , Davenport Rebekah , Neate Sandra , Yu Maggie , Jelinek Pia , Jelinek George Alexander , Reece Jeanette
Published: January 2024

Background

Digital technologies have afforded people living with multiple sclerosis (MS) access to telehealth consultations, diagnostic tools, and monitoring. Although health care professionals remain the most trusted source of information, the internet has emerged as a valuable resource for providing MS-related information, particularly during the COVID-19 pandemic. Notably, people living with MS are increasingly seeking educational content for a range of topics related to the self-management of MS; however, web-based information seeking remains largely underevaluated. To address this gap and ensure that web-based health-related information is accessible and engaging, this study used qualitative methods to analyze the reflections from participants of web-based educational programs for people living with MS.

Objective

This study aimed to explore the motivations, behaviors, and expectations of web-based health information seeking for people living with MS.

Methods

We conducted semistructured interviews for 38 people living with MS 1 month after they completed the novel MS Online Course, which provided information on modifiable lifestyle-related risk factors for people living with MS. Of the 38 participants, 22 (58%) completed the intervention course and 16 (42%) completed the standard care course. Inductive thematic analysis was used within a qualitative paradigm, and 2 authors coded each interview separately and arrived at themes with consensus.

Results

We identified 2 themes: motivation to learn and MS information on the web. The diagnosis of MS was described as a pivotal moment for precipitating web-based information seeking. People living with MS sought lifestyle-related information to facilitate self-management and increase control of their MS. Although social media sites and MS websites were considered useful for providing both support and information, discretion was needed to critically appraise information. Recognizable institutions were frequently accessed because of their trustworthiness.

Conclusions

This study provided novel insights into the motivations of people living with MS for seeking web-based health information. Furthermore, their preferences for the content and format of the web-based information accessed and their experiences and reactions to this information were explored. These findings may guide educators, researchers, and clinicians involved in MS care to optimize the engagement and processing of web-based health information seeking by people living with MS.
Effectiveness of Non-face-to-face Behavioral Activation Treatment for Negative Symptoms of Schizophrenia population (Preprint)
Authors: Kim Won-Hyoung , Kim Hee Seon , Lee Tae Joo , Koo Hoon Jung
Published: January 2024

BACKGROUND

Behavioral activation (BA) improved negative symptoms in patients with schizophrenia.

OBJECTIVE

The purpose of this study was to examine the effectiveness of non-face-to-face BA treatment of negative symptoms in patients with schizophrenia.

METHODS

This study was double-blinded, and placebo-controlled. A total of 98 patients with schizophrenia participated until the end of the study. (49 to BA treatment and 49 to treatment as usual TAU). The non-face-to-face BA treatment program was conducted once a week, 40 minutes per session. TAU included pharmacotherapy, case management and supportive psychotherapy. The Positive and Negative Syndrome Scale (PANSS), the Clinical Assessment Interview for Negative Symptoms (CAINS), and the Behavioral Activation for Depression Scale (BADS) was measured.

RESULTS

PANSS negative decreased in the BA treatment group (22.695.13 vs. 18.905.38, P=.003), whereas it did not change in the TAU group (20.824.61 vs. 19.906.00). There was a statistically significant difference in the degree of improvement from pre- to post-treatment in PANSS negative (P<.001), the CAINS total score (P<.001), and the CAINS motivation/pleasure (P<.001) in the BA treatment group compared to TAU group.

CONCLUSIONS

Non-face-to-face BA treatment is a more effective psychological treatment than TAU for negative symptoms of patients with schizophrenia. Additionally, BA treatment might increase motivation/pleasure and behavioral activation.

CLINICALTRIAL

ClinicalTrials.gov ID ‘NCT05764148’
Exploring E-cigarettes: Ingredients, Health Effects, and Considerations for Use
Authors:   Binghamton University Libraries, Chung Jae Moon
Published: January 2024

Electronic cigarettes, or e-cigarettes are becoming an increasingly popular nicotine delivery system, especially among adolescents and college aged students. They appeal to this population because they are new, are convenient to use, have appealing flavors, and are viewed as a cleaner, safer alternative to cigarettes. However, there are known ingredients in both the e-cigarette solution and vapors that have significant health effects and it is becoming an emerging public health issue that needs to be addressed. There is a gap in the knowledge about the potential harmful effects of e-cigarettes on both the part of the user and the healthcare providers who may need to counsel a user of e-cigarettes, since a lot of evidence is still emerging related to the health effects of e-cigarette use. To address this gap in knowledge, this paper summarizes some of the literature related to e-cigarette use, their health and safety effects that could be used to inform both users and healthcare providers, specifically nurses and nurse practitioners. There is still much to be learned about the long-term effects of e-cigarette use and what healthcare providers can do to minimize those effects.