bluuebunny/crossref_metadata_2025 huggingface dataset:
The epidemiology and associated factors of non-exclusive breastfeeding: a comparative cross-sectional study of livelihood-secure and insecure areas
Authors: Negesse Ayenew , Girma Tsinuel , Desalegn Beruk Berhanu , Kerac Marko , Berhane Melkamu
Published: May 2024

Introduction

Regardless of national commitment, non-exclusive breastfeeding (NEBF) is a public health problem that worsens over time. It can be associated with sociodemographic, economic, and environmental factors and may vary depending on livelihood security. Hence, this study aimed to determine the magnitude of NEBF and identify its associated factors by considering two areas with varied degrees of livelihood security.

Methods

This study represented a comparative cross-sectional survey of 1,060 under 6 months (u6m) infant–mother pairs. Both descriptive and analytic statistics were evaluated using STATA version 17 packages. A binary logistic regression was used to identify associated factors of NEBF. The odds ratio (OR) with a 95% confidence interval (CI) was used to measure the significance of the association at a p-value of <0.05.

Results

The pooled magnitude of 51% of NEBF mothers (95% CI: 48.0, 54.0) was 53.1% (95% CI: 49.2, 57.0) and 48.1% (95% CI: 43.4, 52.8) in livelihood-secure and livelihood-insecure areas, respectively. The lack of recollecting the infant’s birth date by mothers (AOR = 2.4; 95% CI = 1.15–4.40) had the highest odds of NEBF while household heads with tertiary education (AOR = 0.14; 95% CI = 0.01–0.54) and the poorest households (AOR = 0.43; 95%CI = 0.20–0.82) had the lowest odds of NEBF in livelihood-secure areas but not in livelihood-insecure areas. Moreover, mothers with male infants (AOR = 1.9; 95% CI = 1.18–2.92) had high odds of NEBF in livelihood-insecure areas but not in livelihood-secure areas. Infants of 2 to less than 4-month-old (AOR = 8.5; 95% CI = 3.47–18.63) and 4 to less than 6-month-old (AOR = 22.2; 95% CI = 8.02–51.97) in livelihood-secure areas and infants of 2 to less than 4-month-old (AOR = 4.3; 95% CI = 1.29–11.67) and 4 to less than 6-month-old (AOR = 8.3; 95% CI = 2.44–22.39) in livelihood-insecure areas had high odds of NEBF.

Conclusion

Over half of the mothers were practicing NEBF, which represents a failure to meet national and international targets. Area vulnerability to livelihood security modifies factors of NEBF. Male infants in insecure areas, infants of unknown age in secure areas, and infants aged 2 months or older, regardless of setting, were more vulnerable to NEBF. However, households with the lowest wealth and higher household head educational status in livelihood-secure areas were less vulnerable to NEBF. Hence, livelihood-based interventions targeting mothers of 2 to less than 6-month-old infants, with emphasis on these factors, may help address and reduce NEBF.
Efficiently recording and processing data from arbuscular mycorrhizal colonization assays using AMScorer and AMReader
Authors: Jarratt-Barnham Edwin , Oldroyd Giles E. D. , Choi Jeongmin
Published: May 2024

Arbuscular mycorrhizal (AM) fungi engage with land plants in a widespread, mutualistic endosymbiosis which provides their hosts with increased access to nutrients and enhanced biotic and abiotic stress resistance. The potential for reducing fertiliser use and improving crop resilience has resulted in rapidly increasing scientific interest. Microscopic quantification of the level of AM colonization is of fundamental importance to this research, however the methods for recording and processing these data are time-consuming and tedious. In order to streamline these processes, we have developed AMScorer, an easy-to-use Excel spreadsheet, which enables the user to record data rapidly during from microscopy-based assays, and instantly performs the subsequent data processing steps. In our hands, AMScorer has more than halved the time required for data collection compared to paper-based methods. Subsequently, we developed AMReader, a user-friendly R package, which enables easy visualization and statistical analyses of data from AMScorer. These tools require only limited skills in Excel and R, and can accelerate research into AM symbioses, help researchers with variable resources to conduct research, and facilitate the storage and sharing of data from AM colonization assays. They are available for download at https://github.com/EJarrattBarnham/AMReader, along with an extensive user manual.
Relationship between maternal grit and effortful control among 18–21-month-old toddlers
Authors: Jung Awoun , Ishibashi Mikako , Shinya Yuta , Itakura Shoji
Published: May 2024

Grit is known to be effective for long-term academic and social success. However, few studies have focused on the role of grit in parenting and its effect on the development of grit in children. Therefore, this study investigated the effect of maternal grit on children’s effortful control (EC), which is thought to be a precursor to grit, using parenting as a mediating factor. Participants in the current study were 412 children (age range: 18–21 months, M = 34.67 months, SD = 4.51 months) and their mothers. We assessed maternal grit, parenting style, maternal EC, and child EC, and found that maternal grit, maternal EC, and parenting style were positively correlated with child EC. Furthermore, maternal grit was related to EC in children not only directly, but also indirectly through responsive parenting. Additionally, maternal grit was found to be directly related to child EC only when assessed separately from maternal EC. The current study’s findings suggest that maternal grit is directly related to EC in children in a way that differs from the mother’s EC in child-rearing situations.
Mendelian randomization and single-cell expression analyses identify the causal relationship between depression and chronic rhinosinusitis
Authors: Zhou Fangwei , Yang Yan , Li Jianyao , Jin Ying , Zhang Tian , Yu Guodong
Published: May 2024

Background

The causative relationship between chronic rhinosinusitis (CRS) and depression remains unclear. Herein we employed Mendelian randomization (MR) coupled with single-cell analysis to investigate the causality between CRS and depression.

Methods

Data pertaining to CRS and depression were mined from the genome-wide association study database, and a single-cell dataset was sourced from the literature. To explore causality, we conducted bidirectional MR analysis using MR-Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode, with IVW representing the most important method. Further, sensitivity analysis was performed to evaluate the robustness of MR analysis results. Candidate genes were analyzed via single-cell combined MR analysis.

Results

Forward MR analysis indicated depression as a risk factor for CRS when depression was the exposure factor and CRS was the outcome (OR = 1.425, P < 0.001). Reverse MR analysis revealed the same positive relationship between CRS and depression when CRS was the exposure factor and depression was the outcome (OR = 1.012, P = 0.038). Sensitivity analysis validated the robustness of bidirectional MR analysis results. Ten cell types (endothelial, ciliated, basal, myeloid, mast, apical, plasma, glandular, fibroblast, and T cells) were identified in the single-cell dataset. The network of receptor–ligand pairs showed that in normal samples, cell–cell interactions were present among various cell types, such as epithelial, mast, myeloid, and endothelial cells. In contrast, CRS samples featured only one specific receptor–ligand pair, confined to myeloid cells. TCF4 and MEF2C emerged as potentially crucial for CRS-associated depression development.

Conclusions

Our findings suggest a bidirectional causal relationship between CRS and depression, offering a new perspective on the association between CRS and depression.
The worldwide trend in diabetes awareness, treatment, and control from 1985 to 2022: a systematic review and meta-analysis of 233 population-representative studies
Authors: Shahrestanaki Ehsan , Mohammadian Khonsari Nami , Seif Ehsan , Baygi Fereshteh , Ejtahed Hanieh-Sadat , Sheidaei Ali , Djalalinia Shirin , Magliano Dianna J. , Qorbani Mostafa
Published: May 2024

Background

With the rapid increase in the prevalence of DM, studies on the awareness, treatment, and control of this condition are essential. Therefore, this study aimed to review the literature and pool the awareness, treatment, and control of diabetes at the global, regional, and national levels.

Methods

In this systematic review and meta-analysis, several databases, including MEDLINE/PubMed, Institute of Scientific Information (ISI), Scopus, and Google Scholar, were searched using appropriate keywords up to June 2022. Observational studies investigating the awareness, treatment, and control of glucose levels among diabetic individuals were included. Awareness, treatment, and control were defined as the proportion of participants who were aware of their diabetes condition, treated pharmacologically, and achieved adequate glucose control, respectively. Two investigators independently conducted the study selection, data extraction, and quality assessment. Heterogeneity among studies was calculated using Chi-square, and a random-effect meta-analysis was used to pool the rates.

Results

A total of 233 studies published between 1985 and 2022 met the inclusion criteria. The included studies had a combined population of 12,537,968. The pooled awareness of DM was 60% (95%CI: 56–63) and ranged from 41% (25–57) in low-income countries to 68% (64–72) in high-income countries, with no significant trend observed over the assessed periods at the global level. The pooled treatment of DM globally was 45% (42–48) and varied from 37% (31–43) in lower-middle-income countries to 53% (47–59) in high-income countries, showing variation over the examined time period. Before 2000, the proportion of adequate DM control was 16% (12–20), which significantly improved and reached 22% (19–25) after 2010. The pooled awareness, treatment, and control of DM were higher in females, high-income countries, and urban areas compared to males, upper and lower-middle-income countries, and rural areas, respectively. The older adults population had higher awareness and treatment rates than the adult population, but their DM control did not differ significantly.

Conclusion

Despite the high level of awareness and treatment among the diabetic population, treatment success (control) is considerably low, particularly in low-income countries and rural areas. It is crucial to improve awareness, treatment, and control by strengthening the primary care system in all countries.
Exploratory screening for micro-RNA biomarkers in canine multicentric lymphoma
Authors: Hammer Sabine E. , Sprung Julia , Škor Ondřej , Burger Stefanie , Hofer Martin , Schwendenwein Ilse , Rütgen Barbara C.
Published: May 2024

Lymphoma is one of the most frequent hematopoietic tumors in dogs and shares similar features with human counterparts. MicroRNAs (miRNA, small non-coding RNAs) are pivotal in gene regulation fine tuning and cancer hallmarks are influenced by their aberrant expression. Consequently, miRNA biomarkers may assist predicting therapeutic response and clinical outcome by providing less-invasive novel diagnostics tools. The aim of this study was to detect dysregulated miRNAs in lymphomatous lymph node tissues in comparison to lymph node material or PBMCs from healthy control dogs. Potential significant differences in miRNA expression profiles between four lymphoma entities were evaluated. A customized PCR array was utilized to profile 89 canine target miRNAs. Quantification was performed using qPCR, relative expression was determined by the delta–delta Ct method, and p-values were calculated with student’s t-test. In the 14 diffuse large B-cell lymphoma (DLBCL) patients, 28 and 24 different miRNAs were significantly dysregulated compared to lymph node material or PBMCs. Sixteen miRNAs occurred in both control groups, with 12 miRNAs being down- and four miRNAs being upregulated. The six peripheral T-cell lymphoma (PTCL) samples showed 24 and 25 dysregulated miRNAs when compared to the healthy controls. A combined analysis of DLBCL and PTCL samples revealed seven shared and 19 differently expressed miRNAs. Potential biomarkers in T- and B-cell lymphoma could be the miRNA-17/92 cluster and miRNA-181-family together with miRNA-34a and miRNA-150. Diagnostic utility of potential biomarkers must be validated in larger, prospective cohorts of canine lymphoma cases and in higher numbers of physiological patient material.
Application of Irrigation Management and Water-Lifting Technologies to Enhance Fodder Productivity in Smallholder Farming Communities: A Case Study in Robit Bata, Ethiopia
Authors: Hussein Misbah A. , Riga Fikadu T. , Derseh Melkamu B. , Assefa Tewodros T. , Worqlul Abeyou W. , Haileslassie Amare , Adie Abera , Jones Chris S. , Tilahun Seifu A.
Published: May 2024

Small-scale cultivation of irrigated fodder is emerging as a vital production system in mixed farming communities. Efficient water management plays a key role in enhancing forage production, especially in the face of changing climate. A field-scale experimental study was conducted in Robit Bata kebele, Ethiopia, with the following objectives: (1) to examine the effects of conventional farmers’ irrigation scheduling versus climate-based irrigation scheduling; and (2) to assess the influence of water-lifting technologies (manual pulley and solar Majipump) on dry matter yield (DMY), water productivity (WP), irrigation labor productivity (ILP), and water productivity in terms of crude protein and metabolizable energy (WP.CP and WP.ME) of Napier grass. The experiment used 10 farmers’ plots each with a size of 100 m2. Half of the plots were treated using farmers’ scheduling while the other half were treated using climate-based irrigation scheduling. Monitoring of irrigation water use and crop yield took place over two irrigation seasons from November 2020 to June 2021. Results showed there was an interaction effect of irrigation management (p = 0.019) and water-lifting technologies (p = 0.016) with season on DMY. The highest DMY occurred in the first irrigation season with climate-based scheduling and solar Majipump use. The interaction effect of irrigation management and season affected WP (p = 0.047). Climate-based scheduling had a higher WP in the first season, while farmers’ scheduling had a higher WP during the second season. On average, the solar Majipump outperformed the pulley, achieving 5 kg m−3 WP compared to the pulley’s 4 kg m−3 (p = 0.018). Emphasizing the seasonal impact, it is recommended to promote full irrigation (climate-based) in the first season for maximum yield and WP. Conversely, in the second season, advocating only deficit irrigation is advised due to water scarcity and sustainability concerns. Statistical parity in DMY and lower WP with full irrigation in the second season supports this recommendation, addressing the challenge of optimizing water use in the context of a changing climate and ensuring sustainable smallholder agriculture practices. Therefore, implementing appropriate irrigation management alongside efficient water-lifting technologies holds the potential to enhance fodder productivity and bolster smallholder farmers’ livelihoods. Future research should explore the comparative benefits of irrigated fodder versus other crops and the overall advantages of investing in irrigated fodder over vegetables.
Towards Extensive Definition and Planning of Energy Resilience in Buildings in Cold Climate
Authors: Rehman Hassam ur , Hamdy Mohamed , Hasan Ala
Published: May 2024

The transition towards a sustainable future requires the reliable performance of the building’s energy system in order for the building to be energy-resilient. “Energy resilient building in cold climates” is an emerging concept that defines the ability to maintain a minimum level of indoor air temperature and energy performance of the building and minimize the occupant’s health risk during a disruptive event of the grid’s power supply loss in a cold climate. The aim is to introduce an extensive definition of the energy resilience of buildings and apply it in case studies. This article first reviews the progress and provides an overview of the energy-resilient building concept. The review shows that most of the relevant focus is on short-term energy resilience, and the serious gap is related to long-term resilience in the context of cold regions. The article presents a basic definition of energy resilience of buildings, a systematic framework, and indicators for analyzing the energy resilience of buildings. Terms such as active and passive habitability, survivability, and adaptive habitable conditions are defined. The energy resilience indicators are applied on two simulated Finnish case studies, an old building and a new building. By systematic analysis, using the defined indicators and thresholds, the energy resilience performance of the buildings is calculated and compared. Depending on the type of the building, the results show that the robustness period is 11 h and 26 h for the old building and the new building, respectively. The old building failed to provide the habitability conditions. The impact of the event is 8.9 °C, minimum performance (Pmin) is 12.54 °C, and degree of disruption (DoD) is 0.300 for the old building. The speed of collapse (SoC) is 3.75 °C/h, and the speed of recovery (SoR) is 0.64 °C/h. On the other hand, the new building performed better such that the impact of the event is 4 °C, Pmin is 17.5 °C, and DoD is 0.138. The SoC is slow 3.2 °C/h and SoR is fast 0.80 °C/h for the new building. The results provide a pathway for improvements for long-term energy resilience. In conclusion, this work supports society and policy-makers to build a sustainable and resilient society.
The Effects of Eye Illuminance Distribution in the Horizontal Field of View on Human Performance in a Home Paper-Based Learning Situation
Authors: Luo Yuanyi , Zhao Yixiang , Zhang Xin , Niu Bentian , Xia Hongxing , Wang Wei
Published: May 2024

Previous studies have focused on task/ambient illumination for visual effects and eye illumination for non-visual effects. In this context, eye illumination within the non-visual realm was defined as vertical non-visual eye illuminance. Considering the functional specificity of central vision and peripheral vision, this study aims to explore whether the distribution of eye illuminance in the horizontal field of view (FOV) affects human performance in home paper-based learning settings. In this study, a within-subject design was used to investigate the effects of eye illuminance distribution on mental perception, task performance, and physiological health while maintaining constant task illuminance and correlated color temperature (CCT). The findings revealed that eye illuminance and its distribution in the horizontal FOV had complex effects on visual fatigue, Landolt ring performance, heart rate variability, and luminous environment appraisal. A relatively optimal lighting configuration was suggested—Scene 4, which was characterized by an eye illuminance level in central FOV of 186 lx and an “m” shaped eye illuminance distribution pattern. This indicates the importance of considering eye illuminance distribution in the horizontal FOV, rather than solely focusing on vertical eye illuminance.
Integration of Smart Cities and Building Information Modeling (BIM) for a Sustainability Oriented Business Model to Address Sustainable Development Goals
Authors: Liu Zhen , Liu Yixin , Osmani Mohamed
Published: May 2024

The construction industry, business models, and smart cities are recognized as pivotal domains with profound implications for fostering sustainability, prompting extensive research endeavors. However, there remains a dearth of interdisciplinary integration within this sphere aimed at fostering sustainable development. Nevertheless, current studies suggest that research in this area could provide theoretical and practical guidance for the sustainable transformation of society and make a positive contribution to the realization of the Sustainable Development Goals (SDGs). Therefore, this paper aims to utilize an innovative mixed research approach combining macro-quantitative bibliometric analysis with subsequent micro-qualitative content examination based on the SDGs to explore the relationship between BIM and smart cities in promoting a sustainability-oriented business model, which provides a comprehensive understanding of the overall situation and development of research topics in the field and contributes to the improvement of the SDGs. The results show that, during the last 13 years (from the year 2011 to 2023), the period from the year 2011 to 2016 was the initial stage of the field, followed by a rapid growth after the year 2018, of which “BIM”, “Smart City”, “Business Model”, “Building Life Cycle”, “Urban Management”, and “Business Model Innovation” are the keywords representing the current research hotspots. The circular economy model that has been developed since 2021 has contributed to life cycle stages, including “briefing stages” and “procurement stages”. As such, the “whole life cycle”, “strategic urban planning frameworks”, and “sustainable business models” have become future research trends, whilst real-world applications such as “smart tourism”, “e-government”, and “green building” have emerged. Further, the key partnerships of “city managers”, “corporate enterprises”, and “public participation” for smart cities contribute to the achievement of SDGs 8 and 17 in terms of integrating urban information technology and urban infrastructure, policy regulation, knowledge-sharing, improving economic efficiency, and promoting sustainable economic growth.
Recent Developments on CO2 Hydrogenation Performance over Structured Zeolites: A Review on Properties, Synthesis, and Characterization
Authors: Cutad Methene Briones , Al-Marri Mohammed J. , Kumar Anand
Published: May 2024

This review focuses on an extensive synopsis of the recent improvements in CO2 hydrogenation over structured zeolites, including their properties, synthesis methods, and characterization. Key features such as bimodal mesoporous structures, surface oxygen vacancies, and the Si/Al ratio are explored for their roles in enhancing catalytic activity. Additionally, the impact of porosity, thermal stability, and structural integrity on the performance of zeolites, as well as their interactions with electrical and plasma environments, are discussed in detail. The synthesis of structured zeolites is analyzed by comparing the advantages and limitations of bottom-up methods, including hard templating, soft templating, and non-templating approaches, to top-down methods, such as dealumination, desilication, and recrystallization. The review addresses the challenges associated with these synthesis techniques, such as pore-induced diffusion limitations, morphological constraints, and maintaining crystal integrity, highlighting the need for innovative solutions and optimization strategies. Advanced characterization techniques are emphasized as essential for understanding the catalytic mechanisms and dynamic behaviors of zeolites, thereby facilitating further research into their efficient and effective use. The study concludes by underscoring the importance of continued research to refine synthesis and characterization methods, which is crucial for optimizing catalytic activity in CO2 hydrogenation. This effort is important for achieving selective catalysis and is paramount to the global initiative to reduce carbon emissions and address climate change.
Molecular Markers in Melanoma Progression: A Study on the Expression of miRNA Gene Subtypes in Tumoral vs. Benign Nevi
Authors: Prodan Mihaela , Costescu Sergiu , Elagez Ahmed , Laitin Sorina Maria Denisa , Bloanca Vlad , Crainiceanu Zorin , Seclaman Edward , Toma Ana-Olivia , Fericean Roxana Manuela , Puenea George , Cozma Gabriel Veniamin
Published: May 2024

This study investigates the differential expression of miRNA gene subtypes in tumoral versus benign nevi in individuals with melanoma, aiming to identify clinically significant correlations that could serve as reliable markers for assessing tumor stage and progression. Conducted between 2019 and 2022, this descriptive, quantitative observational research analyzed 90 formalin-fixed paraffin-embedded (FFPE) samples from the Pius Brinzeu County Emergency Clinical Hospital, Timisoara, including 45 samples of advanced-stage melanoma and 45 samples of pigmented nevi. miRNA purification and analysis were performed using the miRNeasy Kit and the Human Cancer PathwayFinder miScript miRNA PCR Array, with statistical analysis (including logistic regression) to determine associations with cancer staging, such as high Breslow index risk, number of mitoses, and vascular invasion. After the analysis and comparison of 180 miRNA gene subtypes, we selected 10 of the most upregulated and 10 most downregulated genes. The results revealed that hsa-miR-133b, hsa-miR-335-5p, hsa-miR-200a-3p, and hsa-miR-885-5p were significantly upregulated in melanoma samples, with fold changes ranging from 1.09 to 1.12. Conversely, hsa-miR-451a and hsa-miR-29b-3p showed notable downregulation in melanoma, with fold changes of 0.90 and 0.92, respectively. Additionally, logistic regression analysis identified hsa-miR-29b-3p (OR = 2.51) and hsa-miR-200a-3p (OR = 2.10) as significantly associated with an increased risk of a high Breslow index, while hsa-miR-127-3p and hsa-miR-451a were associated with a reduced risk. Conclusively, this study underscores the significant alterations in miRNA expression in melanoma compared to benign nevi and highlights the potential of specific miRNAs as biomarkers for melanoma progression. The identification of miRNAs with significant associations to melanoma characteristics suggests their utility in developing non-invasive, cost-effective diagnostic tools and in guiding therapeutic decisions, potentially improving patient outcomes in melanoma management.
Malposition of Central Venous Catheter into Coronary Sinus throughout the Persistent Left Superior Vena Cava and Other Complications Related to Catheterization
Authors: Syska Barbara , Veer Anna S. , Matusik Patrycja S. , Jarczewski Jarosław D. , Krzanowska Katarzyna , Popiela Tadeusz J.
Published: May 2024

This case concentrates on the persistent left superior vena cava (PLSVC), a rare vascular anomaly which contributes to central venous catheter (CVC) misplacement. A 72-year-old woman with renal insufficiency presented to the hospital with recurrent bleeding from her permanent CVC device placed in the right common jugular vein. An initial attempt to replace the device was unsuccessful, necessitating the placement of a secondary catheter in the left jugular vein. Shortly after the procedure, the patient developed swelling of the face and neck. Further diagnostic imaging, including a chest radiograph and computed tomography (CT), revealed CVC misplacement in the PLSVC and coronary sinus, thrombosis of the common jugular vein, and a posterior mediastinal hematoma. Conservative therapy of the mediastinal hematoma was implemented and proved effective in this case. A temporary CVC was inserted into the left femoral vein. Two months later, the catheter underwent further dysfunction and a decision was made to place a long-term permanent CVC via the right femoral vein. The patient is currently awaiting an arteriovenous fistula for dialysis use. This case emphasizes the importance of radiological techniques for CVC procedural placement, as well as the detection of congenital abnormalities. Providers regularly placing CVCs should have an in-depth knowledge of the possible complications and potential anatomical variations, especially as seen in high-risk patients.
Comparative Evaluation of Chest Ultrasonography and Computed Tomography as Predictors of Malignant Pleural Effusion: A Prospective Study
Authors: Shehata Samah M. , Almalki Yassir Edrees , Basha Mohammad Abd Alkhalik , Hendy Rasha Mohamed , Mahmoud Eman M. , Abd Elhamed Marwa Elsayed , Alduraibi Sharifa Khalid , Aboualkheir Mervat , Almushayti Ziyad A. , Alduraibi Alaa K. , Basha Ahmed M. Abdelkhalik , Alsadik Maha E.
Published: May 2024

Malignant pleural effusion (MPE) is a manifestation of advanced cancer that requires a prompt and accurate diagnosis. Ultrasonography (US) and computed tomography (CT) are valuable imaging techniques for evaluating pleural effusions; however, their relative predictive ability for a malignant origin remains debatable. This prospective study aimed to compare chest US with CT findings as predictors of malignancy in patients with undiagnosed exudative pleural effusion. Fifty-four adults with undiagnosed exudative pleural effusions underwent comprehensive clinical evaluation including chest US, CT, and histopathologic biopsy. Blinded radiologists evaluated the US and CT images for features suggestive of malignancy, based on predefined criteria. Diagnostic performance measures were calculated using histopathology as a reference standard. Of the 54 patients, 33 (61.1%) had MPEs confirmed on biopsy. No significant differences between US and CT were found in detecting parietal pleural abnormalities, lung lesions, chest wall invasion, or liver metastasis. US outperformed CT in identifying diaphragmatic pleural thickening ≥10 mm (33.3% vs. 6.1%, p < 0.001) and nodularity (45.5% vs. 3%, p < 0.001), whereas CT was superior for mediastinal thickening (48.5% vs. 15.2%, p = 0.002). For diagnosing MPE, diaphragmatic nodularity detected by US had 45.5% sensitivity and 100% specificity, whereas CT mediastinal thickening had 48.5% sensitivity and 90.5% specificity. Both US and CT demonstrate reasonable diagnostic performance for detecting MPE, with particular imaging findings favoring a malignant origin. US may be advantageous for evaluating diaphragmatic pleural involvement, whereas CT is more sensitive to mediastinal abnormalities.
Is Thailand Attractive to Japanese Companies?
Authors: Sakurai Hiroaki
Published: May 2024

This study examines the relationship between the business sentiment of Japanese companies regarding promising or potential countries for investment and macroeconomic statistics, such as economic or population growth in Thailand, using data from the Survey Report on Overseas Business Operations by Japanese Manufacturing Companies from 1992 to 2022. Although investing in Thailand has been popular among Japanese companies since the late 1980s, it has seemingly become relatively inactive in recent years. The present study’s results are summarized as follows: First, the business sentiment of Japanese companies has some relationships with relatively short-term economic growth and the business cycle in the short run. Second, business sentiment depends on long-term trends, and this stance may have changed after 2020. Third, other elements, such as minimum wage or fewer young people, do not necessarily have a relationship with business sentiment. Although more studies including capital accumulation or the global value chain should be conducted, improving the sentiments of Japanese businesspersons is desirable.
The Academic System Influence on Instructional Change: A Conceptual Systems Dynamics Model of Faculty Motivation to Adopt Research-Based Instructional Strategies (RBIS)
Authors: Cruz-Bohorquez Juan Manuel , Adams Stephanie G. , Bravo Flor Angela
Published: May 2024

Many universities have implemented initiatives to drive instructional change, yet their success has often been limited due to a lack of recognition of academia as a complex dynamic system. This paper explores how the interconnected and dynamic nature of academic systems influences faculty motivation to adopt instructional innovations, such as project-based learning (PBL) and small group collaborations (SGCs). We present a Conceptual Systems Dynamics Model (CSDM) that illustrates these interconnections, demonstrating how systemic factors create feedback loops that either reinforce or hinder faculty motivation, as well as other related factors. These loops, represented as Causal Loop Diagrams (CLDs), were derived from literature reviews and qualitative data obtained from interviews and focus groups involving 17 faculty and administrators within an Engineering Department at a research university in South America. The paper identifies thirteen CLDs, comprising seven reinforcing dynamics that positively influence faculty motivation and six balancing dynamics that exert negative pressure. Using empirical evidence and analysis, we describe how the systemic factors influence faculty motivation, and how shifts in motivation reciprocally impact these interconnected factors. By elucidating the complex dynamics at play, this research contributes to a deeper understanding of how to promote sustainable instructional change within academic institutions.
How Can the University Environment Support Student Quality of Life? A Novel Conceptual Model
Authors: Dodd Alyson Lamont , Punton Georgia , McLaren Joanna Mary Averill , Sillence Elizabeth , Byrom Nicola
Published: May 2024

During emerging adulthood (18–25 years), university students have taken steps towards independent living and learning. However, they are also in a liminal phase before the ‘stable roles’ of adulthood. This developmental context distinguishes them from both adolescents and peers who are not attending university. In order to support student well-being, their unique priorities and concerns need to be taken into consideration. This qualitative study explored what life domains were important to students, and what influenced Quality of Life (QoL) within these, in order to build a novel conceptual model of student QoL. Individual interviews (n = 18) were conducted with undergraduate students (aged 18–25 years). The themes derived via Template Analysis were Supportive and Rewarding University Studies, Personal Growth, Social Support, Concerns about Finances and Financial Independence, Physical Environment, Physical and Mental Well-being, and Maintaining Balance. As well as conceptualising QoL in students, this model has practical value for operationalising student QoL. It is a framework to help universities to understand the needs and priorities of students and provide well-being initiatives in line with these needs.
Enhancing a Deep Learning Model for the Steam Reforming Process Using Data Augmentation Techniques
Authors: Pizoń Zofia , Kimijima Shinji , Brus Grzegorz
Published: May 2024

Methane steam reforming is the foremost method for hydrogen production, and it has been studied through experiments and diverse computational models to enhance its energy efficiency. This study focuses on employing an artificial neural network as a model of the methane steam reforming process. The proposed data-driven model predicts the output mixture’s composition based on reactor operating conditions, such as the temperature, steam-to-methane ratio, nitrogen-to-methane ratio, methane flow, and nickel catalyst mass. The network, a feedforward type, underwent training with a comprehensive dataset augmentation strategy that augments the primary experimental dataset through interpolation and theoretical simulations of the process, ensuring a robust model training phase. Additionally, it introduces weights to evaluate the relative significance of different data categories (experimental, interpolated, and theoretical) within the dataset. The optimal artificial neural network architecture was determined by evaluating various configurations, with the aim of minimizing the mean squared error (0.00022) and maximizing the Pearson correlation coefficient (0.97) and Spearman correlation coefficient (1.00).
Nanofluidic Study of Multiscale Phase Transitions and Wax Precipitation in Shale Oil Reservoirs
Authors: Lu Zhiyong , Wan Yunqiang , Xu Lilong , Fang Dongliang , Wu Hua , Zhong Junjie
Published: May 2024

During hydraulic fracturing of waxy shale oil reservoirs, the presence of fracturing fluid can influence the phase behavior of the fluid within the reservoir, and heat exchange between the fluids causes wax precipitation that impacts reservoir development. To investigate multiscale fluid phase transition and microscale flow impacted by fracturing fluid injection, this study conducted no-water phase behavior experiments, water injection wax precipitation experiments, and water-condition phase behavior experiments using a nanofluidic chip model. The results show that in the no-water phase experiment, the gasification occurred first in the large cracks, while the matrix throat was the last, and the bubble point pressure difference between the two was 12.1 MPa. The wax precipitation phenomena during fracturing fluid injection can be divided into granular wax in cracks, flake wax in cracks, and wax precipitation in the matrix throat, and the wax mainly accumulated in the microcracks and remained in the form of particles. Compared with the no-water conditions, the large cracks and matrix throat bubble point in the water conditions decreased by 6.1 MPa and 3.5 MPa, respectively, and the presence of the water phase reduced the material occupancy ratio at each pore scale. For the smallest matrix throat, the final gas occupancy ratio under the water conditions decreased from 32% to 24% in the experiment without water. This study provides valuable insight into reservoir fracture modification and guidance for the efficient development of similar reservoirs.
Numerical Investigation of Rotor and Stator Matching Mode on the Complex Flow Field and Pressure Pulsation of a Vaned Centrifugal Pump
Authors: Du Leilei , Zheng Fankun , Gao Bo , Gad Mona , Li Delin , Zhang Ning
Published: May 2024

The match of rotor and stator blades significantly affects the flow field structure and flow-induced pressure pulsation characteristics inside the pump. In order to study the effects of the rotor and stator matching mode on the complex flow field and pressure pulsation of a centrifugal pump with a vaned diffuser, this paper designs three different vaned diffusers (DY5, DY8 and DY9) and uses the DDES (Delayed Detached Eddy Simulation) numerical method combined with structured grids to simulate the unsteady flow phenomena of the model pump under rated conditions. The results show that, under different rotor and stator matching modes, the pressure pulsation spectrum is dominated by the blade passing frequency and its harmonics. The matching mode of the rotor and stator significantly affects the time–frequency domain characteristics of the pressure pulsation inside the pump, and it is observed that the pressure pulsation energy of vaned diffusers with more blades is significantly smaller than that of fewer-blade vaned diffusers in comparison to the energy of the pressure pulsation at the blade passing frequency and within the 10–1500 Hz frequency band. Combined with the distribution characteristics of the complex flow field inside the pump, it can be found that increasing the number of vaned diffuser blades can reduce the energy of flow-induced pressure pulsation, improve the distribution of high-energy vortices in the interaction zone and stabilize the flow inside the centrifugal pump effectively.
Molecular Mechanisms of Metabolic Syndrome
Authors: Vesa Cosmin Mihai , Zaha Dana Carmen , Bungău Simona Gabriela
Published: May 2024

Metabolic syndrome represents a cluster of conditions, such as abdominal obesity, hypertension, dyslipidemia, and hyperglycemia, that are highly prevalent in developed countries because of unhealthy lifestyles [...]
FGF23 as a Potential Pathophysiological Factor in Peripheral Arterial Disease Associated with Chronic Kidney Disease
Authors: Donate-Correa Javier , Martín-Núñez Ernesto , Hernández-Carballo Carolina , González-Luis Ainhoa , Mora-Fernández Carmen , Martín-Olivera Alberto , Rodríguez-Ramos Sergio , Cerro-López Purificación , López-Castillo Ángel , Delgado-Molinos Alejandro , López-Tarruella Victoria Castro , Navarro-González Juan F.
Published: May 2024

Fibroblast growth factor 23 (FGF23) levels are often elevated in chronic kidney disease (CKD). FGF23 and inflammation are common characteristics in CKD, and both are associated with worse disease progression and the occurrence of complications. The existence of an interaction between FGF23 and inflammation has been suggested, each of which influences the expression and activity of the other, leading to a vicious feedback loop with adverse outcomes, including cardiovascular disease and mortality. In this work, we determined circulating FGF23 levels in a group of patients with CKD stages 3 and 4 subjected to elective femoral endarterectomy due to established peripheral artery disease (PAD), a condition resulting from an athero-inflammatory process, and we studied its associations with different inflammatory markers and mediators. We evaluated its association with serum tumor necrosis factor (TNF)α, interleukin (IL) 6, and IL10, as well as with the gene expression levels of these parameters and A disintegrin and metalloproteinase domain-containing protein (ADAM) 17 in femoral vascular tissue and peripheral blood circulating cells (PBCCs). We also analyzed its association with serum concentrations of C-reactive protein (CRP), the systemic immune inflammation index (SII), and the neutrophil-to-lymphocyte ratio (NLR). Finally, we determined the vascular immunoreactivity of protein TNFα in a subgroup of patients. FGF23 concentrations were independently associated with circulating and PBCC mRNA levels of TNFα. Worst kidney function and diabetes were also found to be contributing to FGF23 levels. Patients with higher levels of FGF23 also had greater vascular immunoreactivity for TNFα.
Metabolite Profiling and Biological Activity Assessment of Paeonia ostii Anthers and Pollen Using UPLC-QTOF-MS
Authors: Jiang Fengfei , Li Mengchen , Huang Linbo , Wang Hui , Bai Zhangzhen , Niu Lixin , Zhang Yanlong
Published: May 2024

Paeonia ostii is an important economic oil and medicinal crop. Its anthers are often used to make tea in China with beneficial effects on human health. However, the metabolite profiles, as well as potential biological activities of P. ostii anthers and the pollen within anthers have not been systematically analyzed, which hinders the improvement of P. ostii utilization. With comprehensive untargeted metabolomic analysis using UPLC-QTOF-MS, we identified a total of 105 metabolites in anthers and pollen, mainly including phenylpropanoids, polyketides, organic acids, benzenoids, lipids, and organic oxygen compounds. Multivariate statistical analysis revealed the metabolite differences between anthers and pollen, with higher carbohydrates and flavonoids content in pollen and higher phenolic content in anthers. Meanwhile, both anthers and pollen extracts exhibited antioxidant activity, antibacterial activity, α-glucosidase and α-amylase inhibitory activity. In general, the anther stage of S4 showed the highest biological activity among all samples. This study illuminated the metabolites and biological activities of anthers and pollen of P. ostii, which supports the further utilization of them.
Available Therapeutic Options for Corneal Neovascularization: A Review
Authors: Drzyzga Łukasz , Śpiewak Dorota , Dorecka Mariola , Wyględowska-Promieńska Dorota
Published: May 2024

Corneal neovascularization can impair vision and result in a poor quality of life. The pathogenesis involves a complex interplay of angiogenic factors, notably vascular endothelial growth factor (VEGF). This review provides a comprehensive overview of potential therapies for corneal neovascularization, covering tissue inhibitors of metalloproteinases (TIMPs), transforming growth factor beta (TGF-β) inhibitors, interleukin-1L receptor antagonist (IL-1 Ra), nitric oxide synthase (NOS) isoforms, galectin-3 inhibitors, retinal pigment epithelium-derived factor (PEDF), platelet-derived growth factor (PDGF) receptor inhibitors, and surgical treatments. Conventional treatments include anti-VEGF therapy and laser interventions, while emerging therapies such as immunosuppressive drugs (cyclosporine and rapamycin) have been explored. Losartan and decorin are potential antifibrotic agents that mitigate TGF-β-induced fibrosis. Ocular nanosystems are innovative drug-delivery platforms that facilitate the targeted release of therapeutic agents. Gene therapies, such as small interfering RNA and antisense oligonucleotides, are promising approaches for selectively inhibiting angiogenesis-related gene expression. Aganirsen is efficacious in reducing the corneal neovascularization area without significant adverse effects. These multifaceted approaches underscore the corneal neovascularization management complexity and highlight ideas for enhancing therapeutic outcomes. Furthermore, the importance of combination therapies and the need for further research to develop specific inhibitors while considering their therapeutic efficacy and potential adverse effects are discussed.
Molecular Chaperonin HSP60: Current Understanding and Future Prospects
Authors: Singh Manish Kumar , Shin Yoonhwa , Han Sunhee , Ha Joohun , Tiwari Pramod K. , Kim Sung Soo , Kang Insug
Published: May 2024

Molecular chaperones are highly conserved across evolution and play a crucial role in preserving protein homeostasis. The 60 kDa heat shock protein (HSP60), also referred to as chaperonin 60 (Cpn60), resides within mitochondria and is involved in maintaining the organelle’s proteome integrity and homeostasis. The HSP60 family, encompassing Cpn60, plays diverse roles in cellular processes, including protein folding, cell signaling, and managing high-temperature stress. In prokaryotes, HSP60 is well understood as a GroEL/GroES complex, which forms a double-ring cavity and aids in protein folding. In eukaryotes, HSP60 is implicated in numerous biological functions, like facilitating the folding of native proteins and influencing disease and development processes. Notably, research highlights its critical involvement in sustaining oxidative stress and preserving mitochondrial integrity. HSP60 perturbation results in the loss of the mitochondria integrity and activates apoptosis. Currently, numerous clinical investigations are in progress to explore targeting HSP60 both in vivo and in vitro across various disease models. These studies aim to enhance our comprehension of disease mechanisms and potentially harness HSP60 as a therapeutic target for various conditions, including cancer, inflammatory disorders, and neurodegenerative diseases. This review delves into the diverse functions of HSP60 in regulating proteo-homeostasis, oxidative stress, ROS, apoptosis, and its implications in diseases like cancer and neurodegeneration.
Nano(bio)Materials Do Not Affect Macrophage Phenotype—A Study Conducted by the REFINE Project
Authors: David Christopher A. W. , Vermeulen Jolanda P. , Gioria Sabrina , Vandebriel Rob J. , Liptrott Neill J.
Published: May 2024

Macrophages are well known for their involvement in the biocompatibility, as well as biodistribution, of nano(bio)materials. Although there are a number of rodent cell lines, they may not fully recapitulate primary cell responses, particularly those of human cells. Isolation of tissue-resident macrophages from humans is difficult and may result in insufficient cells with which to determine the possible interaction with nano(bio)materials. Isolation of primary human monocytes and differentiation to monocyte-derived macrophages may provide a useful tool with which to further study these interactions. To that end, we developed a standard operating procedure for this differentiation, as part of the Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices (REFINE) project, and used it to measure the secretion of bioactive molecules from M1 and M2 differentiated monocytes in response to model nano(bio)materials, following an initial assessment of pyrogenic contamination, which may confound potential observations. The SOP was deployed in two partner institutions with broadly similar results. The work presented here shows the utility of this assay but highlights the relevance of donor variability in responses to nano(bio)materials. Whilst donor variability can provide some logistical challenges to the application of such assays, this variability is much closer to the heterogeneous cells that are present in vivo, compared to homogeneous non-human cell lines.