bluuebunny/crossref_metadata_2025 huggingface dataset:
Akibat Hukum Perjanjian Perkawinan yang dibuat Pasca Perkawinan yang tidak diumumkan, yang Berakibat Terhadap Kerugian Pihak Ketiga
Authors: Novany Nadya , Fajri Mekka Putra Mohamad
Published: January 2023

Marriage is the inner bond between a man and a women as husband and wife with the aim of forming a happy and everlasting family that based on the lordship of the almighty. The marriage agreement is a very important thing in the course of marriage. The marriage agreement in the civil code and the Marriage Law is a joint agreement between husband and wife ratified by the registrar of marriages at the time or before the marriage is held. Both parties by mutual consent may enter into a written agreement authorized by the marriage registration employee, as the content applies also to third parties to the extent that the third party is caught. For this reason, what about the regulations regarding marriage agreements and the legal consequences of marriage agreements made after the marriage takes place and are not announced.
Abstrak
Perkawinan adalah ikatan batin antara laki-laki dan perempuan sebagai suami-istri dengan tujuan membentuk keluarga yang bahagia dan kekal berdasarkan ketuhanan Yang Maha Esa. Perjanjian perkawinan merupakan suatu hal yang sangat penting dalam berlangsungnya perkawinan. Perjanjian Perkawinan dalam KUHPerdata maupun UU Perkawinan merupakan persetujuan bersama antara suami dan istri yang disahkan oleh Pegawai Pencatat Perkawinan pada waktu atau sebelum perkawinan dilangsungkan. Kedua pihak atas persetujuan bersama dapat mengadakan perjanjian tertulis yang disahkan oleh Pegawai Pencatatan Perkawinan, sebagaimana isinya berlaku juga terhadap pihak ketiga sepanjang pihak ketiga tersangkut. Untuk itu bagaimana dalam peraturan mengenai perjanjian perkawinan dan akibat hukum terhadap perjanjian perkawinan yang dibuat setelah perkawinan berlangung dan tidak diumumkan.
Pembatalan Akta Perjanjian Pengikatan Jual Beli Tanah
Authors: Inawati Inawati
Published: January 2023

The basis for land ownership can be in the form of a Sale Purchase Deed, a Will or a Grant through the transfer of rights to land or goods first. However, the sale and purchase agreement exists as an alternative to buying and selling between the parties, which can be done through a private deed or can also be done through a deed drawn up before a notary. The deed of sale and purchase binding is often referred to in the form of an authentic deed drawn up before an authorized official, either a Notary or a Land Deed Making Officer (PPAT) who has valid evidentiary powers. Every agreement entered into by the parties must be carried out in accordance with their abilities and in good faith, so that all the rights and obligations of each party stipulated in the agreement can be fulfilled perfectly. This is an ideal implementation of the agreement for the parties involved. In the community there are still many problems in the cancellation of the land sale and purchase binding agreement deed and the settlement process. These problems may arise due to differences in interpretation, lack of understanding between one party and another, as well as disputes because one party cannot comply. If the problems in the agreement cannot be resolved by way of deliberation, litigation and alternative dispute resolution, then the settlement of problems in the agreement can be done by canceling the agreement based on the applicable law.
Abstrak
Dasar kepemilikan tanah bisa di dapat berupa Akta Jual Beli, Wasiat atau Hibah yang melalui pemindahan hak atas tanah atau barang-barang terlebih dahulu. Namun pengikatan jual beli hadir sebagai alternatif jual beli antara para pihak dapat melalui akta dibawah tangan atau dapat pula dilakukan melalui suatu akta yang dibuat dihadapan notaris. Akta pengikatan jual beli sering disebut dalam bentuk akta otentik yang dibuat dihadapan pejabat yang berwenang baik Notaris ataupun Pejabat Pembuat Akta Tanah (PPAT) yang memiliki kekuatan pembuktian yang sah. Setiap perjanjian yang dibuat oleh para pihak harus dapat dilaksanakan sesuai dengan kemampuan dan dengan adanya itikad baik, sehingga segala hak dan kewajiban dari masing-masing pihak yang diatur dalam perjanjian tersebut dapat dipenuhi dengan sempurna. Hal ini merupakan pelaksanaan perjanjian yang ideal bagi pihak-pihak yang terkait. Di masyarakat masih banyak permasalahan dalam pembatalan akta perjanjian pengikatan jual beli tanah dan proses penyelesaiannya. Permasalahan tersebut mungkin muncul karena adanya perbedaan penafsiran, kurang kesepahaman antara para pihak yang satu dan yang lain, serta perselisihan karena salah satu pihak memang tidak dapat memenuhinya. Apabila permasalahan dalam perjanjian belum dapat diselesaikan dengan cara musyawarah, litigasi dan alternatif penyelesaian sengketa maka penyelesaian permasalahan dalam perjanjian dapat dilakukan pembatalan perjanjian berdasarkan undang-undang yang berlaku.
Anti-Candida activity of terpenes from Salvia ovalifolia, S. procurrens and S. uliginosa, native to South Brazil
Authors: Da Silva Sousa Cristiano , Mezzomo Letícia , Butzge Juliana Caroline , Meirelles Gabriela de Carvalho , Bordignon Sérgio Augusto de Loreto , Von Poser Gilsane Lino , Apel Miriam
Published: January 2023

The essential oils of Salvia ovalifolia, S. procurrens and S. uliginosa were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. The three species displayed very low amounts of essential oils, consisting of a few sesquiterpenes, and aliphatic compounds such as aldehydes and long-chain fatty acids. From the leaves of S. uliginosa, an exudate was obtained which presented the diterpene icetexone as the major component. The exudate and icetexone were evaluated for the activity against Candida species, both showing inhibition of fungal growth.
Quality evaluation of solid pharmaceutical preparations for veterinary use containing cephalexin
Authors: Gomes Carpes Camila , Venturi Caroline , Steppe Martin
Published: January 2023

The analysis of pharmaceuticals is fundamental in both human and veterinary medicine. In this context, quality control must accompany the process from the acquisition of raw material to the transformation into a finished product, since its goal is to ensure safe and effective drugs for human or animal consumption. Considering the significant increase in veterinary prescriptions containing antimicrobial drugs, the present work carried out a search for information about the qualification of veterinary preparations available in the national market, highlighting, through legislation, the quality parameters applied to pharmaceutical products for veterinary use. The quality of solid pharmaceutical preparations containing cephalexin, acquired in the national veterinary pharmaceutical market, was also evaluated. The six different brands of cephalexin tablets and coated tablets analyzed in this study were approved with regard to identification, average weight, determination of mechanical strength in tablets, disintegration test, and content. The results of the determination of the content varied between 94.9% and 103%, being within the limits indicated for preparations for human use, as recommended by USP 44 and the Brazilian Pharmacopeia 6th edition. Even so, it is important to emphasize the need for improvement in the legislation that regulates the quality control of medicines for veterinary use, since the norms are not very specific, with an absence of parameters, specifications, and release procedures that ensure which tests should be performed. This study is a perspective that can bring subsidies for investigations of other therapeutic classes, considering the large number of formulations available in the Brazilian market of veterinary medicines.
ENLAÇAMENTOS E PROPOSTAS PARA PENSAR A EDUCAÇÃO EM ESPAÇOS DE RESTRIÇÃO E PRIVAÇÃO DE LIBERDADE
Authors: Onofre Elenice , Caldas Edla
Published: January 2023

O artigo apresenta concepções de educação, educação escolar e não escolar, educação na e da prisão e socioeducação, correlacionadas ao fenômeno da restrição e privação de liberdade (RPL) de jovens e adultos, na perspectiva libertadora. Ancora-se na perspectiva freiriana de sociedade e de educação, na qual ambas se opõem à opressão das classes populares ocasionada pelas desigualdades sociais. Nessa perspectiva, traz-se a socioeducação como criadora de espaços e de acontecimentos situados organicamente no mundo, com atividades concretas de formação do ser no tempo presente, objetivando a continuidade da vida numa constante possibilidade de ser mais. As concepções apresentadas permitem exercitar o pensar no grupo de todos os brasileiros e de seus direitos, incluindo-se as pessoas que se encontram em RPL.
A LITERATURA COMO INTERPRETAÇÃO DO BRASIL E DA AMÉRICA LATINA
Authors: De Oliveira Elise Aparecida
Published: January 2023

Darcy Ribeiro foi um dos maiores intérpretes da sociedade brasileira. A literatura é um dos atalhos que o intelectual encontrou para pensar o Brasil e, por extensão, a América Latina. Em alguma medida, o antropólogo-ficcionista extrapola o texto ficcional dialogando diretamente com o contexto histórico, cultural e social que ele traçou em sua obra antropológica, criando uma espécie de romance de tese, para instigar novas reflexões sobre os problemas persistentes no país.
GOLIAS E DAVI: CIÊNCIAS HUMANAS VERSUS CIÊNCIAS BIOMÉDICAS
Authors: Neves dos Reis Nilo Henrique Neves dos Reis
Published: January 2023

A história da humanidade tem repetidamente mostrado que um egoísmo silencioso apenas espera a oportunidade para se manifestar. Seja no plano político, seja nas questões éticas que envolvem pesquisas com seres humanos, é significativo apontar que a busca de novos conhecimentos científicos não pode prescindir de uma ética responsável nas suas próprias atividades. E se as ciências, sejam as biomédicas, sejam as de humanidades, transformam participantes das investigações em objetos de seus experimentos, por suas especificidades científicas, então não restará muita coisa para fazer com as sobras das pesquisas. Discussões acerca da reflexão ética são imprescindíveis, motivo pelo qual o controle social da pesquisa com seres humanos, é parte constituinte que assegura os direitos e deveres dos participantes e pesquisadores envolvidos na investigação científica.
GRANDEZA DE DARCY RIBEIRO
Authors: Maia Leonardo
Published: January 2023

Darcy Ribeiro 100 anos. Grandeza de Darcy. Grandeza como paradoxo, em meio a um povo ainda pequeno, ou menor do que seria. A ele, Darcy se devota: procura pensá-lo, configurá-lo, dar voz à sua ‘ninguendade’, confunde-se a ele do início ao fim. O centenário, via de regra, é momento de ressaltar um legado. Mas como, se o próprio Darcy se disse, mais de uma vez, derrotado? Essa derrota é porém cheia de encantos, encrustada em vários dos grandes eventos do país e do mundo, ou mesmo pessoais: amores. De Darcy, talvez se deva dizer o que Deleuze disse de Proust: um processo de intensa liberação de signos. Cuja decifração confunde-se, em parte, com o próprio enigma brasileiro dos últimos cem anos. Voltar a Darcy é voltar a pensar a nossa ontologia frustrada, o nosso ainda não-ser. Darcy enfrentou a tudo como grande vivente. Talvez sejam precisos mais cem anos para nos aproximarmos melhor da sua imprudência.
A Leadership Intervention Targeting Job Satisfaction Among ABA Practitioners
Authors: Morgan Stephanie M. , Burnett Mitze , Firebaugh Casey Mace
Published: January 2023

Organizational culture shapes workplace dynamics and employee relations. Leaders contribute to this by setting the parameters for behavioral expectations and modeling them. In this pilot study, it was hypothesized that a motivational email would increase job satisfaction and increase completion rates of clinical notes. Pretest posttest T-tests were performed to determine significant differences between scores in the experimental and control group. The results indicated a significant difference in job satisfaction when receiving a positive motivational email. The completion of clinical notes increased and there was a significant difference in completing clinical notes when receiving a positive motivational email. The findings of this study aligned with the current literature available on the topic of employee job satisfaction. Using these findings to make shifts in the way an organization operates and provides a positive work environment for their employees will yield happier employees who have a higher level of performance.
Impact of selection process on employees’ performance: A case of Lebanese small and medium enterprises
Authors: Daw Dory N. , Tawk Charles J.
Published: January 2023

The main objective of this paper is to explore if the selection process has an impact on employees’ performance inside Lebanese small and medium-sized enterprises (SMEs). The research was conducted in SMEs located in the Greater Beirut area in which the empirical study consists of a quantitative method. The results have shown that the selection process has a full impact on employees’ performance and retention inside Lebanese SMEs. This study contributes to mitigating selection errors among SMEs that forms the backbone of the Lebanese economy and hence reducing their turnover expenses, and increasing their longevity. This paper concludes that SMEs shall consider seriously the selection process in hiring.
The influence of debt-to-equity ratio, capital intensity ratio, and profitability on effective tax rate in the tourism sector
Authors: Chang Andreas , Meiryani Meiryani , Sumarwan Ujang , Gunawan Theresia , Devi Sonnya Rahma , Samukri Samukri , Salim Gazali
Published: January 2023

Masri and Martani (2012) explain agency problems that arise with the existence of influenceive tax rate due to differences in interests between the shareholder and management. Influence tax rate aims to apply tax regulations correctly to achieve the expected profit efficiency. This study examines the influence of debt level, capital intensity ratio (CIR), and company profitability on influenceive tax rates. Effective tax rate is measured in this paper, the debt level is measured using debt-to-equity ratio (DER), profitability is measured using return on assets (ROA) and the CIR shows property fixed assets in the company by compared total assets owned. The population in this study is the tourism sub-sector that has been audited and listed on the Indonesia Stock Exchange (IDX). This research period was conducted for 3 (three) years using a purposive sampling method. In this study, the data analysis techniques used were descriptive statistical analysis, classical assumption test, multiple linear regression analysis, F-test, t-test, and coefficient of determination test using the Statistical Product and Service Solutions (SPSS) program. The results of this study indicate that the level of debt, capital intensity ratio, and company profitability does not influence effective tax rate. This shows that if DER, ROA, and CIR have increased or decreased, the effective tax rate is not affected.
Las TIC en la formación universitaria durante la pandemia COVID-19: perspectivas de estudiantes de Comunicación en el Perú
Authors: Castañeda-Maizel Andrea-Jalla , Tito-Estevez Haydee-Katherine , Mateus Julio-César
Published: January 2023

La pandemia por COVID-19 repercutió en la educación al optar por la virtualidad como única opción para sobrellevar el derecho a la misma. Este artículo presenta los resultados de una investigación de enfoque mixto que incluyó encuestas (n=100) y dos grupos focales a estudiantes de la carrera de Comunicación de una universidad pública y otra privada de la ciudad de Lima, Perú, con el objeto de analizar el uso de las TIC en el desarrollo de las clases según la perspectiva de estos en el contexto de la COVID-19.
Los hallazgos reflejan dificultades relacionadas con el equipamiento e infraestructura sobre todo en las clases prácticas (talleres), la importancia de la relación afectiva entre los estudiantes y los docentes para un óptimo desarrollo de las clases, así como la compartición de información personal que puede afectar la privacidad de los mismos. Los participantes proponen sugerencias de mejora para que la virtualidad siga siendo parte del proceso educativo a pesar del regreso a las aulas.
Editorial
Authors: Izquierdo Barrera Martha Lucía
Published: January 2023

Nos complace presentar a nuestros lectores y público en general el primer número del volumen 17 de la Revista Miradas - 2022 de la Facultad de Ciencias de la Educación de la Universidad Tecnológica de Pereira.

En esta edición continuamos trabajando en el posicionamiento de la revista tanto en el ámbito local, nacional e internacional. 

Este número de 2022 trae cinco artículos que muestran resultados de investigación, revisión y reflexión alrededor de categorías como la educación, la comunicación y la cultura a través de temas como las políticas públicas como las TIC y la formación universitaria, Covid-19, prácticas pedagógicas, primera infancia, empleo, pronombres, derecho penal y lavado de dinero. 

La lectura inicia con el primer trabajo titulado “Las TIC en la formación universitaria durante la pandemia COVID-19: Perspectivas de estudiantes de Comunicación en el Perú”, es un trabajo resultado de investigación en el cual se habla de la implementación de las TIC en los procesos de formación virtual a causa de la pandemía por Covid-19 en Perú. 

El segundo artículo titulado “Resignificación de las prácticas pedagógicas: la reflexión docente y su implicación con la primera infancia” es un trabajo resultado de investigación donde se asume el análisis, resignificación y reflexión generada desde la práctica pedagógica docente al proceso de enseñanza y aprendizaje de niños y niñas de primera infancia según las políticas públicas de educación emitidas por el Ministerio de Educación Nacional MEN para el territorio colombiano.

Continuando con este ejercicio de presentación, el tercer artículo titulado “Precarización de las condiciones del empleo en Ciudad Juárez, Chihuahua, México 2021” y hace aprte de los resultados de investigación  El objetivo central fue el caracterizar las condiciones laborales de la población ocupada en Ciudad Juárez, Chihuahua, México a través de la creación de un Índice de Precariedad del Empleo (IPE) que represente de manera resumida la precarización del empleo por sexo y grupo de edad.

Así mismo, el cuarto artículo titulado “El uso de los pronombres de tratamiento tú, usted y vos en el departamento del Quindío”, hace parte de los resultado de una investigaciónesta titulada “Tratamiento pronominal en el Quindío”, el objetivo principal de esta investigación fue analizar el uso de los pronombres de tratamiento en este departamento a través de encuestas a personas cuyas edades oscilaron entre los 12 y 70 años.

En este punto, se da un giro temático, el quinto artículo titulado “Derecho penal del enemigo para combatir el delito de lavado de dinero en México” que es resultado de investigación del fenómeno delictivo del lavado de dinero en México, se sanciona conforme a ordenamientos jurídicos tanto internacionales como nacionales.

 

Esperamos que esta publicación sea del agrado de nuestros lectores.

Dra. Martha Lucía Izquierdo Barrera

Directora Revista miradas
Cuarentena: experiencias de consumo y afrontamiento de colombianos isleños y continentales
Authors: Docal Millán María del Carmen , Cabrera García Victoria Eugenia , Mclean Chaves Rosa Elvira , Quincosis Sanabria Leidy Johana
Published: January 2023

En Colombia, por causa de la pandemia del covid-19, las personas estuvieron en aislamiento estricto entre marzo y septiembre de 2020, lo que obligó a las familias a desarrollar en casa todas las actividades de la vida cotidiana. En este contexto, los cambios en el consumo y las estrategias de afrontamiento aparecen como temas de interés por sus implicaciones en la salud y el bienestar de las personas. En esta situación también es pertinente tener en cuenta que Colombia tiene dos zonas territoriales marcadas: la continental y la isleña, compuesta por el archipiélago de San Andrés, Providencia y Santa Catalina. La continental, a pesar de la diversidad entre regiones, mantiene patrones comunes y la isleña, una fuerte particularidad cultural tanto en su estructura social como en su población raizal. Objetivo: conocer las diferencias entre un grupo de colombianos, hombres y mujeres, continentales e isleños, en su vivencia de la cuarentena según los cambios en el consumo y las estrategias de afrontamiento. Metodología: estudio cuantitativo de tipo descriptivo, transversal, mediante cuestionario en línea. Participaron 1252 hombres y mujeres colombianos, mayores de 18 años, residentes en Colombia en la zona continental e isleña. Resultados: los isleños consumieron más alimentos y medicamentos que los continentales, y estos consumieron más bebidas alcohólicas y realizaron más compras por internet. Los hombres consumieron más bebidas alcohólicas, cigarrillo y sustancias psicoactivas, y las mujeres más medicamentos. Los isleños utilizaron más estrategias de afrontamiento, como acudir a apoyo intrafamiliar, apoyo profesional, actividades espirituales y de ocio. Las mujeres acudieron más que los hombres a la participación en actividades espirituales como estrategia de afrontamiento. Conclusiones: durante el confinamiento por el covid-19, las personas vivieron muchas circunstancias particulares que jamás habían vivido; por esta razón, tuvieron que acudir a estrategias de afrontamiento centradas en la búsqueda de apoyo en otras personas y en la ejecución de actividades que les ayudaran a sentirse aliviados mental y emocionalmente.
Relación entre supervisión o monitoreo, empatía y comportamiento agresivo en adolescentes escolarizados de Bogotá
Authors: Guevara Marín Ivon Paola , Arango Diago Tatiana , Monroy Cano Katherine Paola
Published: January 2023

El propósito de esta investigación consistió en analizar la relación entre la supervisión o monitoreo, la empatía y el comportamiento agresivo –verbal y físico– en adolescentes escolarizados de Bogotá. El estudio es de tipo descriptivo-correlacional de corte trasversal.
La muestra estuvo conformada por 324 adolescentes escolarizados en la ciudad de Bogotá, con edades comprendidas entre los 11 a 18 años: 158 adolescentes de sexo femenino (48,76 %) y 166 de sexo masculino (51,24 %).
Los resultados mostraron que la divulgación o comunicación espontánea de las actividades de los adolescentes hacia la madre se relaciona de manera inversa con el comportamiento agresivo, específicamente la agresión física en adolescentes de sexo masculino. Así mismo, se encontró que la empatía es la variable predictora con mayor peso en la aparición de la agresión física en adolescentes de sexo masculino; mientras que las variables independientes: comunicación abierta de papá, control parental de papá y empatía logran explicar el 24,6 % de la variabilidad de la agresión verbal en adolescentes mujeres.
Consideraciones Sobre El Rol Del Estado Y El Mercado En La Economía Cubana
Authors: Guillén Jorge Ignacio
Published: January 2023

Este trabajo propone una reflexión sobre la economía cubana a partir del criterio de que la persona ha de ser considerada como centro y fin de la actividad económica. La economía, más que buscar los tradicionales objetivos de crecimiento y eficiencia económica, debe –sobre todo– estar al servicio de la persona. Para ello tanto el Estado como el mercado, deben complementarse y articularse como medios que garanticen la primacía de la persona y promuevan su desarrollo pleno. El objetivo de la investigación precedente es reflexionar sobre estas cuestiones –poco debatidas en la realidad cubana–, pero que conviene abordarlas para que el cambio que necesita la economía avance por un camino coherente con el Desarrollo Humano Integral (DHI).
Responsabilidad de la intelectualidad cubana en la consolidación de los mitos del discurso ideológico, la propaganda y la represión política
Authors: Valle Amir
Published: January 2023

En los estudios literarios cubanos se refiere la participación de la intelectualidad cubana en los procesos sociales ocurridos en la isla desde los mismos inicios de esa nación. Aunque gran parte de esos estudios hablan del protagonismo de los intelectuales en la lucha contra el poder colonial español, y las dictaduras o las democracias corruptas en la primera mitad del siglo XX, solo unos pocos hablan sobre la responsabilidad intelectual en la consolidación de los mecanismos de censura, represión cultural y política en el período revolucionario (1959 hasta el presente). Basado en una experiencia de cuatro décadas como protagonista de la cultura cubana en la isla y la diáspora, el autor reflexiona sobre este fenómeno.
A case of cardiopulmonary arrest on arrival due to pilsicainide intoxication
Authors: Takahashi Yoshihito , Matsuura Hiroshi , Hino Hiroshi , Chujoh Satoru , Kishimoto Masafumi
Published: January 2023

A 22-year-old male was admitted to our hospital after taking 2450 mg of
pilsicainide. On admission, the patient was in cardiac arrest, and
percutaneous cardiopulmonary support was introduced to maintain his
circulation. After three days of intensive care, he was no impaired
consciousness and transferred another hospital for psychological
problem.
Deep learning analysis of mid-infrared microscopic imaging data for the diagnosis and classification of human lymphomas
Authors: Zelger Philipp , Brunner Andrea , Zelger Bettina , Willenbacher Ella , Unterberger Seraphin , Stalder Roland , Huck Christian , Willenbacher Wolfgang , Pallua Johannes
Published: January 2023

The present study presents an alternative analytical workflow that
combines mid-infrared (MIR) microscopic imaging and deep learning to
diagnose human lymphoma and differentiate between small and large cell
lymphoma. We could show that using a deep learning approach to analyze
MIR hyperspectral data obtained from benign and malignant lymph node
pathology results in high accuracy for correct classification, learning
the distinct region of 3900 cm-1 to 850 cm-1. The accuracy is above 95%
for every pair of malignant lymphoid tissue and still above 90% for the
distinction between benign and malignant lymphoid tissue for binary
classification. These results demonstrate that a preliminary diagnosis
and subtyping of human lymphoma could be streamlined by applying a deep
learning approach to analyze MIR spectroscopic data.
Modified Technique in Sample Preparation for Light Microscopy with Oil Immersion Objective Lens Imaging
Authors: Isaac Ubi Essien , Oyo-Ita Emmanuella , Ije Eze Lazarus , Igwe Nancy Paulina
Published: January 2023

Background: There is a growing need for contemporary
application of microscopic techniques in laboratory practice. Moreover,
the oil immersion microscopy is rarely done because of its intricacy. As
such concerned scientists need to be abreast of the step-by-step
procedures for preparing a biological specimen on the whole as well as
method for increasing the resolving power of a microscope. Aim:
To prepare slides from various organ systems with photomicrographs of
different resolutions. Materials and Methods: Tissue samples
were sourced from laboratory Wistar rats ( Rattus norvegicus).
Other research items included histopathology lab reagents as well as
equipment including embedding mould, water bath, oven and rotary
microtome. Standard method of paraffin embedding was used with some
modification and sections stained with hematoxylin (Harris) and eosin.
Images were prepared using a photomicroscope connected to a computer
interface. Results: 500 pieces of microscope slides
encompassing 20 different organ/tissue samples, with each mounted on 25
glass slides, while the photomicrographs taken at low (x100), high
(x400) and higher (x1000) power magnifications were produced from the
various specimens and saved on a disk. Conclusion: The outcome
demonstrates the adequacy of the histological protocol used to guide
researchers in related fields.
Heat Transfer of MHD Flow over a Wedge with Surface of Mutable Temperature
Authors: Moghimi Seyed Morteza , MFarsi *
Published: January 2023

The current study focuses on the thermal distribution in the boundary
layer of a wedge with a variable surface temperature. The governing
equations of MHD flow for variable wall temperature conditions can be
converted to ODE by using similarity solutions, and the Hartmann number
(Ha) from 1 to 3 can be solved via the colocation method. This method’s
results are compared to those of the numerical method, and it is then
evaluated and validated. As the angle or Ha increases, the width of the
hydrodynamic boundary layer decreases, and the slope of the boundary
layer increases, increasing the coefficient of friction on the surface.
The results are obtained for variable wall temperature (n), Prandtl
number (Pr) and Eckert number (Ec), where they are 0.5≤n≤1.5, 0.5≤Pr≤5,
and 0.001≤Ec≤0.002, and at a certain angle. It is observed that when Ha,
Pr, and n increase, the thermal boundary layer grows faster than before;
thus, thickness decreases and the Nusselt number (Nu) rises; however, as
the Ec adds, the Nu decreases on the wall.
Modeling Hippocampal Spatial Cells in Rodents navigating in 3D environments
Authors: AZIZ AZRA , Patil Bharat , Lakshmikanth Kailash , Peesapati Sreeharsha , Mukhopadhyay Ayan , Chakravarthy Srinivasa
Published: January 2023

Studies on the neural correlates of navigation in 3D environments are
plagued by several unresolved issues. For example, experimental studies
show markedly different place cell responses in rats and bats, both
navigating in 3D environments. In an effort to understand this
divergence, we propose a deep autoencoder network to model the place
cells and grid cells in a simulated agent navigating in a 3D
environment. We also explore the possibility of a vital role that Head
Direction (HD) tuning plays in determining the isotropic or anisotropic
nature of the observed place fields in different species. The input
layer to the autoencoder network model is the HD layer which encodes the
agent’s HD in terms of azimuth (θ) and pitch angles (ϕ). The output of
this layer is given as input to the Path Integration (PI) layer, which
integrates velocity information into the phase of oscillating neural
activity. The output of the PI layer is modulated and passed through a
low pass filter to make it purely a function of space before passing it
to an autoencoder. The bottleneck layer of the autoencoder model encodes
the spatial cell like responses. Both grid cell and place cell like
responses are observed. The proposed model is verified using two
experimental studies with two 3D environments in each. This model paves
the way for a holistic approach of using deep neural networks to model
spatial cells in 3D navigation.
Development and application of the Branched and Isoprenoid GDGT Machine learning Classification algorithm (BIGMaC) for paleoenvironmental reconstruction
Authors: Martínez-Sosa Pablo , Tierney Jessica , Perez-Angel Lina C , Stefanescu Ioana Cristina , Guo Jingjing , Kirkels Frédérique Marie Sophie Anne , Sepúlveda Julio , Peterse Francien , Shuman Bryan N , Reyes Alberto
Published: January 2023

Glycerol dialkyl glycerol tetraethers (GDGTs), including both the
archaeal isoprenoid GDGTs (isoGDGTs) and the bacterial branched GDGTs
(brGDGTs), have been used in paleoclimate studies to reconstruct
temperature in marine and terrestrial archives. However, GDGTs are
present in many different types of environments, with relative
abundances that strongly depend on the depositional setting. This
suggests that GDGT distributions can be used more broadly to infer
paleoenvironments in the geological past. In this study, we analyzed
1153 samples from a variety of modern sedimentary settings for both
isoGDGT and brGDGTs. We used machine learning on the GDGT relative
abundances from this dataset to relate the lipid distributions to the
physical and chemical characteristics of the depositional settings. We
observe a robust relationship between the depositional environment and
the lipid distribution profiles of our samples. This dataset was used to
train and test the Branched and Isoprenoid GDGT Machine learning
Classification algorithm (BIGMaC), which identifies the environment a
sample comes from based on the distribution of GDGTs with high accuracy.
We tested the model on the sedimentary record from the Giraffe
kimberlite pipe, an Eocene maar in subantarctic Canada, and found that
the BIGMaC reconstruction agrees with independent stratigraphic
information, provides new information about the paleoenvironment of this
site, and helps improve paleotemperature reconstruction. In cases where
paleoenvironments are unknown or are changing, BIGMaC can be applied in
concert with other proxies to generate more refined paleoclimatic
records.
Centuries-old journey of deli through language, literature and history
Authors: Djindjic Marija
Published: January 2023

The paper is on the analyses of the usage of lexemes of Turkish origin deli
and delija in Serbian. Aiming to present a complete image of the semantic
transformation of these loanwords, the Serbian language, literary and
historical material is compared with the relevant Turkish data. In Turkish
the lexeme deli represents both an adjective and a noun, while in Serbian,
there is the adjective deli and the noun delija. The lexeme deli occurs very
often in Serbian folk poems as attribute attached to the name of a brave
hero (deli-Radivoje, deli-Marko) and is also an indispensable attribute
attached to the names of Oguz heroes in the heroic epic poem The Book of
Dede Korkut. In these epic works the adjective deli is used in the same
meaning in both languages, meaning brave, fearless. The semes brave,
fearless from the semantic content of lexeme delija, meaning a member of a
cavalry unit of the Ottoman army, have induced secondary meanings brave man,
hero; strong, personable man. The primary meaning (crazy) which the
adjective deli has in Turkish is at the periphery of polysemantic structure
in Serbian, confirmed just as a regional word. Lexemes deli and delija in
Serbian and deli (adjective and noun) in Turkish have been independently
semantically developed according to universal process of polysemy in both
languages.
Svetislаv Vulovic’s Notebook
Authors: Milosavljevic Boris
Published: January 2023

The National Library of Serbia holds numerous collections of manuscripts.
Among them is a notebook attributed to Bozidar Knezevic (1862-1905),
philosopher, historian and translator from English, French, German and
Russian into the Serbian language. After thorough analysis of the
manuscript, chronology, and published papers the author of the Notebook
referred to, we could conclude that Notebook did not belong to Bozidar
Knezevic, but Svetislav Vulovic (1847-1898), literary critic and literary
historian, professor of Belgrade Faculty of Philosophy, member of the Royal
Serbian Academy of Sciences. The paper deals with the composition and dating
of the Notebook (1894, 1896, 1897). It considers Vulovic?s diary notes,
reconstruction of his travels in Southern Serbia and Austria-Hungary
(Abbazzia respectively), the identity of the people he met and spoke to. He
recorded the versions of Serbian national epic poems he heard sung to the
gusle, and published them.
Wear and microstructural properties of Ni-B4C/CNF composites
Authors: Islak Serkan , Koç Vahdettin , Gariba Abdualkarim
Published: January 2023

The aim of this study is to investigate the microstructure and wear
properties of nickel (Ni) matrix boron carbide (B4C) and carbon nanofiber
(CNF)-reinforced composite materials. Microstructure and phase composition
of the composites manufactured by powder metallurgy (PM) method were
determined by SEM-EDS and XRD analysis. While hardness values of the
composites were determined by Vickers hardness measurement method, their
wear properties were determined by using pin-on-disc method. SEM images
showed that B4C was homogeneously distributed, but CNF accumulated in some
areas, even though it was slight. Addition of B4C and CNF to the matrix
significantly increased it. The increase was quite high in B4C addition, and
hardness was slightly lower in the addition of CNF. According to the results
of the wear test carried out under dry conditions, the reinforcement to the
Ni matrix reduced the wear rate and friction coefficient.
Influence of calcination temperature on physical and optical properties of nickel chromite nanoparticles
Authors: Kumar Katrapally , Bhavani Sara
Published: January 2023

Nickel chromite nanoparticles were prepared by sol-gel auto combustion method followed by calcination at different temperatures, 700, 900, 1100 and 1300oC for 8h. The prepared nanoparticles were characterized by XRD, SEM, EDS, FTIR and UV-Vis spectroscopy. From the XRD patterns, the Miller indices (hkl) were identified for all the prominent peaks for all the samples, it was clear that the compound crystallized according to spinel structure with a space group of Fd3m. SEM images showed non-uniform agglomerated fragments having a lot of voids and pores. UsingScherrer method, the crystallite size was calculated and found gradually increasing trend with the calcination temperature from 13.73 to 22.33 nm, where as the average grain size was increased from 140.00 to 163.46 nm with calcination temperature. FTIR spectra showed six fundamental absorption bands in the range 500 to 3470 cm-1, whereas the two absorption bands in the range 500-625 cm-1 confirmed the bonding vibrations of metal-oxygen bonds situated at octahedral and tetrahedral sites. UV-Vis spectroscopy was carried out in the wavelength range 200-800 nm and the optical band gap (Eg) was observed in the range 4.2129-4.3115 eV.
Loss of Hematopoietic Cell–Derived Oncostatin M Worsens Diet-Induced Dysmetabolism in Mice
Authors: Albiero Mattia , Ciciliot Stefano , Rodella Anna , Migliozzi Ludovica , Amendolagine Francesco Ivan , Boscaro Carlotta , Zuccolotto Gaia , Rosato Antonio , Fadini Gian Paolo
Published: January 2023

Innate immune cells infiltrate growing adipose tissue and propagate inflammatory clues to metabolically distant tissues, thereby promoting glucose intolerance and insulin resistance. Cytokines of the IL-6 family and gp130 ligands are among such signals. The role played by oncostatin M (OSM) in the metabolic consequences of overfeeding is debated, at least in part, because prior studies did not distinguish OSM sources and dynamics. Here, we explored the role of OSM in metabolic responses and used bone marrow transplantation to test the hypothesis that hematopoietic cells are major contributors to the metabolic effects of OSM. We show that OSM is required to adapt during the development of obesity because OSM concentrations are dynamically modulated during high-fat diet (HFD) and Osm−/− mice displayed early-onset glucose intolerance, impaired muscle glucose uptake, and worsened liver inflammation and damage. We found that OSM is mostly produced by blood cells and deletion of OSM in hematopoietic cells phenocopied glucose intolerance of whole-body Osm−/− mice fed a HFD and recapitulated liver damage with increased aminotransferase levels. We thus uncovered that modulation of OSM is involved in the metabolic response to overfeeding and that hematopoietic cell–derived OSM can regulate metabolism, likely via multiple effects in different tissues.

ARTICLE HIGHLIGHTS
Inflammatory Cell Infiltration Into Islets Without PD-L1 Expression Is Associated With the Development of Immune Checkpoint Inhibitor–Related Type 1 Diabetes in Genetically Susceptible Patients
Authors: Kawata Satoshi , Kozawa Junji , Yoneda Sho , Fujita Yukari , Kashiwagi-Takayama Risa , Kimura Takekazu , Hosokawa Yoshiya , Baden Megu Y. , Uno Sae , Uenaka Rikako , Namai Kazuyuki , Koh Yoko , Tomimaru Yoshito , Hirata Haruhiko , Uemura Motohide , Nojima Satoshi , Morii Eiichi , Eguchi Hidetoshi , Imagawa Akihisa , Shimomura Iichiro
Published: January 2023

Immune checkpoint inhibitors (ICIs) could cause type 1 diabetes (T1D). However, the underlying mechanism remains unclear. We immunohistochemically analyzed pancreatic specimens from three individuals with ICI-related T1D, and their histopathological data were compared those from three patients who had received ICI therapy but did not develop T1D (non-T1D) and seven normal glucose-tolerant subjects as control subjects. All ICI-related T1D patients had susceptible HLA haplotypes. In ICI-related T1D, the β-cell area decreased and the α-cell area increased compared with non-T1D and control subjects. The number of CD3-positive cells around islets increased in ICI-related T1D and non-T1D compared with control subjects, while the number of CD68-positive cells around islets increased in ICI-related T1D compared with non-T1D and control subjects. The expression ratios of programmed death-ligand 1 (PD-L1) on islets decreased in non-T1D and almost completely disappeared in ICI-related T1D, while PD-L1 expression was observed in most cells of pancreatic islets in control subjects. This study, therefore, indicates that ICI therapy itself could reduce PD-L1 expression on islets in all subjects, which may be related to β-cell vulnerability. In addition, we showed that absence of PD-L1 expression on β-cells, genetic susceptibility, and infiltration of macrophages as well as T lymphocytes around islets might be responsible for T1D onset.

ARTICLE HIGHLIGHTS
Predictive Value of C-Peptide Measures for Clinical Outcomes of β-Cell Replacement Therapy in Type 1 Diabetes: Report From the Collaborative Islet Transplant Registry (CITR)
Authors: Baidal David A. , Ballou Cassandra M. , Rickels Michael R. , Berney Thierry , Pattou Francois , Payne Elizabeth H. , Barton Franca B. , Alejandro Rodolfo ,   CITR Investigators
Published: January 2023

OBJECTIVE

To determine C-peptide measures and levels associated with positive glycemic control outcomes following islet transplant (ITx) in type 1 diabetes.

RESEARCH DESIGN AND METHODS

We evaluated Collaborative Islet Transplant Registry (CITR) islet-alone recipients with pretransplant C-peptide <0.1 nmol/L and mean follow-up of 4.6 ± 1.1 years (n = 677). Receiver operating characteristic area under the curve (ROC-AUC) was used to evaluate the predictive value of fasting and stimulated glucose and C-peptide measures for seven primary outcomes: 1) absence of severe hypoglycemic events (ASHEs); 2) HbA1c <7.0%; 3) HbA1c <7.0% and ASHEs; 4) HbA1c ≤6.5%; 5) HbA1c ≤6.5% and ASHEs; 6) insulin independence; and 7) ASHEs, HbA1c ≤6.5%, and insulin independence (the optimal outcome). Measures with the highest ROC-AUC were selected for determination of optimal cut points.

RESULTS

Fasting C-peptide was highly predictive for ASHE (ROC-AUC 0.906; optimal cut point 0.070 nmol/L) and the optimal outcome (ROC-AUC 0.845; optimal cut point 0.33 nmol/L). Mixed-meal tolerance test (MMTT)–stimulated C-peptide-to-glucose ratio (CPGR) outperformed both fasting and stimulated C-peptide for all outcomes except ASHE. The optimal cut point for the optimal outcome was 0.12 nmol/mmol for MMTT-stimulated CPGR and 0.97 nmol/L for MMTT-stimulated C-peptide.

CONCLUSIONS

Fasting C-peptide reliably predicts ITx primary outcomes. MMTT-stimulated CPGR provides marginally better prediction for composite ITx outcomes, including insulin independence. In the absence of an MMTT, a fasting C-peptide ≥0.33 nmol/L is a reassuring measure of optimal islet graft function. C-peptide targets represent excellent and easily determinable means to predict glycemic control outcomes after ITx and should be considered as potential goals of β-cell replacement.
Optimization of Albuminuria-Lowering Treatment in Diabetes by Crossover Rotation to Four Different Drug Classes: A Randomized Crossover Trial
Authors: Curovic Viktor Rotbain , Jongs Niels , Kroonen Marjolein Y.A.M. , Zobel Emilie H. , Hansen Tine W. , Sen Taha , Laverman Gozewijn D. , Kooy Adriaan , Persson Frederik , Rossing Peter , Heerspink Hiddo J.L.
Published: January 2023

OBJECTIVE

Renin–angiotensin system (RAS) inhibitors decrease the urinary albumin to creatinine ratio (UACR) but are ineffective in up to 40% of patients. We hypothesized that rotation through different drug classes overcomes RAS inhibitor resistance and tested this in a randomized crossover trial.

RESEARCH DESIGN AND METHODS

We assigned 26 adults with type 1 diabetes and 37 with type 2 diabetes and UACR between 30 and 500 mg/g and estimated glomerular filtration rate >45 mL/min/1.73 m2 to 4-week treatment periods with telmisartan 80 mg, empagliflozin 10 mg, linagliptin 5 mg, and baricitinib 2 mg in random order, separated by 4-week washout periods. Each participant was then re-exposed for 4 weeks to the drug that induced that individual’s largest UACR reduction. Primary outcome was the difference in UACR response to the best-performing drug during the confirmation period versus UACR response to the other three drugs.

RESULTS

There was substantial variation in the best-performing drug. Telmisartan was best performing for 33 participants (52%), empagliflozin and linagliptin in 11 (17%), and baricitinib in 8 participants (13%). The individuals’ best-performing drug changed UACR from baseline during the first and confirmatory exposures by a mean of −39.6% (95% CI −44.8, −33.8; P < 0.001) and −22.4% (95% CI −29.7, −12.5; P < 0.001), respectively. The Pearson correlation for first versus confirmatory exposure was 0.39 (P = 0.017). The mean change in UACR with the other three drugs was +1.6% (95% CI −4.3%, 8.0%; P = 0.593 versus baseline; difference versus individuals’ best-performing drug at confirmation, 30.9% [95% CI 18.0, 45.3]; P < 0.001).

CONCLUSIONS

We demonstrated a large and reproducible variation in participants’ responses to different UACR-lowering drug classes. These data support systematic rotation through different drug classes to overcome therapy resistance to RAS inhibition.
construção da identidade profissional dos residentes do núcleo Interdisciplinar da residência pedagógica
Authors: Oliveira Júnior Ailton Paulo de , Souza Carla Alves de , Servidoni Maria do Carmo Pereira
Published: January 2023

O objetivo deste trabalho foi analisar as indicações da construção de identidade profissional pelos residentes de uma universidade federal do estado de São Paulo, Brasil, referente às ações do núcleo interdisciplinar/matemática em 2020/2021. O software IRaMuTeQ foi utilizado para a análise textual multidimensional a partir da organização em textos (corpus), sendo cada um deles definido como “segmento de texto”. Cada texto foi elaborado considerando o que foi enfatizado na pesquisa: “De que forma a residência pedagógica contribuiu para sua identidade como docente?” É possível considerar que, mesmo nesse período de atividades remotas e pandemia da Covid-19, os(as) residentes vinculados ao Programa Residência Pedagógica (PRP) consideraram as experiências vivenciadas no programa relevantes para sua formação docente, visto que relataram consideráveis aprendizados que foram fundamentais para a qualificação de sua prática docente e, consequentemente, para a formação de sua identidade profissional.
Ansiedade Matemática
Authors: CAMPOS ANA MARIA ANTUNES DE , MANRIQUE ANA LÚCIA
Published: January 2023

Este trabalho traz elementos de um projeto de doutoramento que tem por objetivos investigar, por meio de uma formação de professores, como os participantes observam os padrões de riscos comportamentais à ansiedade matemática em sala de aula e, consequentemente, analisar as atividades elaboradas por esses professores com vistas a examinar os elementos da Teoria do Flow, e como essas atividades podem ser benéficas para estudantes que apresentam os padrões de riscos comportamentais à ansiedade matemática. A pesquisa, de natureza qualitativa, será realizada por uma formação remota com professores que ensinam matemática. Serão realizadas análises dos registros produzidos pelos professores participantes da formação e, consequentemente, serão apresentados os resultados e conclusões.