bluuebunny/crossref_metadata_2025 huggingface dataset:
A prospective small-sample random controlled trial of navigation system-assisted distraction osteogenesis for hemifacial microsomia based on artificial intelligence
Authors: Liu Xiangqi , Zhang Ziwei , Han Wenqing , Zhao Zhijie , Kim Byeong Seop , Yan Yingjie , Chen Xiaojun , Wang Xuetong , Li Xin , Yang Xianxian , Wang Bingshun , Xu Haisong , Lin Li , Chai Gang
Published: April 2023

Background: Mandibular distraction osteogenesis (MDO) is a major part of the treatment for hemifacial microsomia patients. Due to the narrow surgical field of the intraoral approach, osteotomy accuracy is highly dependent on the surgeons’ experience. Electromagnetic (EM) tracking systems can achieve satisfying accuracy to provide helpful real-time surgical navigation. Our research team developed an EM navigation system based on artificial intelligence, which has been justified in improving the accuracy of osteotomy in the MDO in animal experiments. This study aims to clarify the effect of the EM navigation system in improving the MDO accuracy for hemifacial microsomia patients.
Methods:This study is designed as a single-centered and randomized controlled trial. Altogether 22 hemifacial microsomia patients are randomly assigned to the experiment group and control groups. All patients receive three-dimensional CT scans and preoperative surgical plans. The EM navigation system will be set up for those in the experiment group, and the control group will undergo traditional surgery. The primary outcome is the surgical precision by comparing the osteotomy position of pre- and postoperative CT scan images through the Geomagic Control software. The secondary outcomes include mandibular symmetry (occlusal plane deviation angle, mandibular ramus height and body length), pain scale and complications. Other indications, such as the adverse events of the system and the satisfactory score from patients and their families, will be recorded.
Discussion: This small sample randomized controlled trial intends to explore the application of an EM navigation system in MDO for patients, which has been adopted in other surgeries such as orthognathic procedures. Because of the delicate structures of children and the narrow surgical view, accurate osteotomy and protection of nearby tissue from injury are essential for successful treatment. The EM navigation system based on artificial intelligence adopted in this trial is hypothesized to provide precise real-time navigation for surgeons and optimally improve patients outcomes including function and aesthetic results. The results of this trial will extend the application of new navigation technology in pediatric plastic surgery.
Trial registration: Trial registration: Chinese Clinical Trial Registry: No. ChiCTR2200061565. Registered on June29, 2022.
Non-coding RNAs identification and regulatory networks in pathogen-host interaction in the microsporidia congenital infection
Authors: Shen Zigang , Yang Qiong , Luo Lie , Li Tangxin , Ke Zhuojun , Li Tian , Chen Jie , Meng Xianzhi , Xiang Heng , Li Chunfeng , Zhou Zeyang , Chen Ping , Pan Guoqing
Published: April 2023

Background：
The interaction networks between coding and non-coding RNAs (ncRNAs) including long non-coding RNA (lncRNA), covalently closed circular RNA (circRNA) and miRNA are significant to elucidate molecular processes of biological activities and interactions between host and pathogen. Congenital infection caused by vertical transmission of microsporidia N. bombyciscan result in severe economic losses in the silkworm-feeding industry. However, little is known that about ncRNAs that take place in the microsporidia congenital infection. Here we conducted whole-transcriptome RNA-Seq analyses to identify ncRNAs and regulatory networks for both N. bombycis and host including silkworm embryos and larvae during the microsporidia congenital infection.
Results:
A total of 4,171 mRNAs, 403 lncRNA, 62 circRNAs, and 284 miRNAs encoded by N. bombycis were identified, among which some differentially expressed genes formed cross-talk and are involved in N. bombycis proliferation and infection. For instance, a lncRNA/circRNA competing endogenous RNA (ceRNA) network including 18 lncRNAs, one circRNA, and 20 miRNAs was constructed to describe 14 key parasites genes regulation, such as polar tube protein 3 (PTP3), ricin-B-lectin, spore wall protein 4 (SWP4), and heat shock protein 90 (HSP90). Regarding silkworm host upon N. bombyciscongenital infection, a total of 14,889 mRNAs, 3,038 lncRNAs, 19,039 circRNAs, and 3,413 miRNAs were predicted based on silkworm genome with many differentially expressed coding and non-coding genes during distinct developmental stages. Different species of RNAs form interacting network to modulate silkworm biological processes, such as growth, metamorphosis and immune responses.Furthermore, a lncRNA/circRNA ceRNA network consisting of 140 lncRNAs, five circRNA, and seven miRNAs are constructed hypothetically to describe eight key host genes regulation, such as Toll-6, Serpin-6, inducible nitric oxide synthase (iNOS) and Caspase-8. Notably, cross-species analyses indicate that parasite and host miRNAs play a vital role in pathogen-host interaction in the microsporidia congenital infection.
Conclusion:
This is the first comprehensive pan-transcriptome study inclusive of both N. bombycis and its host silkworm with a specific focus on microsporidia congenital infection, and show that ncRNA-mediated regulation plays a vital role in the microsporidia congenital infection, which provides a new insight into understanding the basic biology of microsporidia and pathogen-host interaction.
Effects of C-S-Hs-PCE and Na2SO4 on hydration behavior of cement-lithium slag binder
Authors: He Yan , Chen Juan , Liu Shuhua , Jiang Mingjing , Hooton R.D.
Published: April 2023

Application of C-S-Hs-PCE and sodium sulfate into Portland cement containing 20 wt% lithium slag (LS) powder was investigated, in order to strengthen early mechanical properties. Synergistic effects of C-S-Hs-PCE and sodium sulfate on hydration properties and microstructure of cement-LS system were analyzed. Results showed that C-S-Hs-PCE was advantageous for modifying fluidity of fresh LS-cement binder, while increased dosage of sodium sulfate decreased dispersibility of fresh paste. C-S-Hs-PCE and sodium sulfate exhibited a synergistic effect on strength enhancement, hydration acceleration as well as setting behavior of LS-cement binder. Sodium sulfate increased alkalinity of interstitial solution and promoted dissolution of LS. Dissolved Al and Si from LS powder reacted with dissolved sulfate ions from sodium sulfate to produce extra hydrates, and C-S-Hs-PCE accelerated pozzolanic reaction as well as hydration reaction via nucleation effect collaborated with dispersing effect. C-S-Hs-PCE accelerated reaction process of sodium sulfate via nucleation effect, and activation effect of sodium sulfate provided more newly-formed hydrates to act as nucleation seeds or crystal skeleton for induce hydration of new phases. The accelerated hydration generated more AFt and C-S-H gel in the matrix. Newly formed hydrates promoted exceedingly the appearance of network, leading to a refinement of pore structure as well as enhancement in mechanical strength. Application of LS into cement as a greener binder could be obtained by synergistic adoption of C-S-Hs-PCE and sodium sulfate.
The Impact of a Love Language Game Intervention on Relationship Satisfaction Among Chinese Couples in China and Malaysia: Examining the Role of Individualism-Collectivism
Authors: Chen Guanzheng , Chen Yanying
Published: April 2023

Background:
Relationship satisfaction is crucial for the well-being and longevity of romantic relationships. Although love language interventions have demonstrated positive effects on relationship satisfaction, most research has focused on Western contexts. This study investigates the impact of a Love Language Game intervention on relationship satisfaction among Chinese couples in China and Malaysia and examines the role of individualism-collectivism in determining the intervention's effectiveness.
Methods:
Employing a mixed-methods approach and a randomized controlled trial design, this study incorporated both quantitative and qualitative components. The quantitative analysis utilized a two-way ANOVA to compare the Love Language Game intervention group with a control group participating in an alternative relationship enhancement workshop series. The qualitative component consisted of interviews exploring participants' experiences and perceptions of the interventions.
Results:
The findings revealed the effectiveness of the Love Language Game intervention in improving relationship satisfaction among Chinese couples and highlighted the influence of individualism-collectivism on the intervention's outcomes. Participants' experiences and perceptions emphasized the significance of engagement, communication, cultural sensitivity, and tailored strategies in relationship interventions.
Conclusions:
This study contributes to the literature on love language-based interventions and their application in culturally diverse settings, offering valuable insights for relationship counsellors, educators, and policymakers. The findings may guide the development and implementation of culturally sensitive interventions to enhance relationship satisfaction and overall well-being in diverse populations.
Applications of λ-dominance degree based rough sets in conflict problems
Authors: Rehman Noor , Ali Abbas , Liu Peide , Park Choonkil , Donganont Mana
Published: April 2023

Multi-attribute group decision making can be considered as the process of ranking alternatives or selecting an optimal alternative by many decision makers based on multiple criteria. By comparing any two alternatives pairwise, the preference relations provide efficient ways to represent the preference degrees of decision makers. The aim of this paper is to propose a general framework for the study of multi-attribute and multi decision information system by introducing the λ-dominance degree based rough set. Applying the notion of λ-dominance degree relation, we propose λ-dominance degree based rough set approach by substituting the dominance relation with λ-dominance degree relation. After employing λ-dominance degree based rough set approach to it for any times, we can only get six different sets at most. That is to say, every rough set in a universe can be approximated by only six sets, where the lower and upper approximations of each set in the six sets are still lying among these six sets. The relationships among these six sets are established. Another theme of the present study is to build two types of approximate precision, rough degree, approximate quality and approximate accuracy and their mutual relationship. Finally, two different algorithms for conflict situation are proposed and we compare the proposed models with other existing models.
A Case Report of Scrub Typhus in Third Trimester of Pregnancy Leading to Multi-organ Dysfunction – A Lesson Learned.
Authors: Singla Rimpi , Katoch Tanvi , Suri Vikas , Biswal Manisha
Published: April 2023

Introduction:
Scrub typhus in pregnancy may present with varying clinical spectrum ranging from mild febrile illness to multi-organ dysfunction. Severe form of untreated disease may result in maternal and/or fetal death. We present the case report of a primigravida in her third trimester of pregnancy with scrub typhus that faced “maternal near miss” and fetal demise.
Case:
A 25-year-old primigravidaat 36 weeks of gestation was referred to us with fever, headache, and malaise for 15 days and progressive dyspnea for two days. She was being treated with antipyretics and non-specific antibiotics before referral. She had tachycardia, hypotension, tachypnoea, orthopnea, oxygen saturation of 90% on room air, and generalized anasarca. Investigations revealed thrombocytopenia, deranged renal function tests, and increased procalcitonin. Azithromycin and ceftriaxone were started empirically. ELISA for Scrub typhus was positive. Subsequently, an eschar was found below left breast. Her condition improved with resuscitation, supportive therapy, and definitive treatment. Patient had spontaneous labor within 24 hours of admission resulting in vaginal delivery. She had intrapartum stillbirth.
After delivery, she again developed respiratory distress requiring intubation. The chest Xray showed a deteriorating picture with consolidation in right upper lung and bilateral reticulo-nodular opacities. Antibiotics were switched to meropenem and doxycycline 100mg twice a day. Fever subsided after day-4 postpartum and she was gradually weaned off from the ventilator.
Conclusions:
It is important to consider this differential early in the course of illness especially in tropical countries. Delay in diagnosis and hence, treatment can result in catastrophic outcome.
A molecular phylogeny of the subfamily Plusiinae (Lepidoptera: Noctuidae) in India inferred from mitochondrial and nuclear ribosomal DNA sequences
Authors: Sinha Twinkle , Shashank P. R.
Published: April 2023

Background The subfamily Plusiinae is an economically important moth pest group under species rich family Noctuidae (Lepidoptera). The evolutionary history of this important subfamily has not been resolved completely. Particularly in India, the genus is represented by a species complex, but the taxonomic delineation between them is still unclear.Methods and results In present study, a comprehensive phylogenetic relationship among Indian species of this subfamily has been inferred for the first time based on mitochondrial marker, Cytochrome Oxidase I (COI), and nuclear gene marker, Ribosomal Protein S5 (RPS5), emphasizing tribal level classification. Here, we analyzed 125 plusiinae taxa from eight biogeographical zones of India comprising 2 molecular markers: mitochondrial marker, Cytochrome Oxidase I (COI), and nuclear gene marker, Ribosomal Protein S5 (RPS5). The results revealed that Plusiinae tribes were monophyletic and considered sister groups that shared many derived characteristics. The ML/MP cladogram based on the barcoding gene successfully separates all the species, but not all tribes. While the nuclear gene marker, RPS5 separated all the species according to their tribes. The combined analysis of both genes showed tribe resolution into distinct clades.Conclusions This is the first comprehensive study on phylogenetic studies of 25 species of plusiinae from India which gives a clear information about species position and arrangement within taxa.
Genetic association between the APOE ε4 allele, toxicant exposures and Gulf War Illness diagnosis
Authors: Abdullah Laila , Nkiliza A , Niedospial D , Aldrich G , Bartenfelder G , Keegan A , Hoffmann M , Mullan M , Klimas N , Baraniuk J , Crawford F , Krengel M , Chao L , Sullivan K
Published: April 2023

Introduction: Exposure to nerve agents, pyridostigmine bromide (PB), pesticides, and oil-well fires during the 1991 Gulf War (GW) are major contributors to the etiology of Gulf War Illness (GWI). Since the apolipoprotein E (APOE) ε4 allele is associated with the risk of cognitive decline with age, particularly in the presence of environmental exposures, and cognitive impairment is one of the most common symptoms experienced by veterans with GWI, we examined whether the ε4 allele was associated with GWI.
Methods: Using a case-control design, we obtained data on APOE genotypes, demographics, and self-reported GW exposures and symptoms that were deposited in the Boston Biorepository and Integrative Network (BBRAIN) for veterans diagnosed with GWI (n = 220) and healthy GW control veterans (n = 131). Diagnosis of GWI was performed using the Kansas and/or Center for Disease Control (CDC) criteria.
Results: Age- and sex-adjusted analyses showed a significantly higher odds ratio for meeting the GWI case criteria in the presence of the ε4 allele (Odds ratio [OR] = 1.84, 95% confidence interval [CI = 1.07 – 3.15], p ≤ 0.05) and with two copies of the ε4 allele (OR = 1.99, 95% CI [1.23 - 3.21], p ≤ 0.01). Combined exposure to pesticides and PB pills (OR = 4.10 [2.12-7.91], p ≤ 0.05) as well as chemical alarms and PB pills (OR = 3.30 [1.56-6.97] p ≤ 0.05) during the war were also associated with a higher odds ratio for meeting GWI case criteria. There was also an interaction between the ε4 allele and exposure to oil well fires (OR = 2.46, 95% CI [1.07-5.62], p ≤ 0.05) among those who met the GWI case criteria.
Conclusion: These findings suggest that the presence of the ε4 allele was associated with meeting the GWI case criteria. Gulf War veterans who reported exposure to oil well fires and have an ε4 allele were more likely to meet GWI case criteria. Long-term surveillance of veterans with GWI, particularly those with oil well fire exposure, is required to better assess the future risk of cognitive decline among this vulnerable population.
The assessment of the associated factors of Emotional divorce among Iranian couples during the Covid19 Pandemic: A descriptive study
Authors: Sadeghzadeh Zahra , Ghodssi-ghassemabad Robabeh , Hamdieh Mostafa , Shariatpanahi Samirasadat , babazadeh faeze , Abdoli Mitra , gelehkolaee Keshvar samadaee
Published: April 2023

Background: Emotional divorce can be defined as an important factor in the boredom of the couple, the cooling of the relationship between them, the feeling of sadness and despair, and the lack of dependence of the couple on each other, which has irreparable consequences for the family. Therefore, the present study was designed to assess the affecting associated factors of emotional divorce among Iranian couples during the Covid19 pandemic.
Methods: A descriptive-analytical study was performed on 900 men and women from 22 districts of Tehran who were selected by the available sampling methods from March to October 2021. Data collection tools are Guttmann demographic and Emotional Divorce Questionnaires. The Questionnaires were completed by the participants of the study. R 4.0.2 software was used to analyze the data, in addition, an independent t-test and chi-square were used to compare the subjects in terms of the emotional divorce. Also, the multiple logistic regression method was used to determine the independent factors affecting emotional divorce.
Results: The results showed that the associated factors of emotional divorce include age, marriage rank, duration of the marriage, choosing the spouse by parents, the education level of the couple, the job of the couple, infection of Covid19, and having disputes before Covid19 infection outbreak.
Conclusion: Emotional divorce is considered as a social harm which could be the prelude of legal divorce. Therefore, the study of affecting factors on it in any society can pave the way for culture-based interventions to reduce such social harms.
Virtual Education as an Academic Model in the Use of Medical Cannabis in Colombia
Authors: Bermúdez-Ocampo Juan S. , Zapata Juan P , Zuluaga Andrés F
Published: April 2023

Background: There is a global tendency to decriminalize the use of cannabis, either medical or recreational. Colombia is no exception and from 2016 it has been legal to produce and prescribe medical cannabis. Nonetheless, like it has happened in other countries, there appears to be neglect to medical education on the subject.
Methods: A Situational analysis was conducted, in which bibliography sources were revised, a survey and questionnaire were conducted, a focus group was developed, a normogram designed and available courses were revised.
Results: The legal framework facilitates the production and prescription of medical cannabis, the survey, the questionnaire, and the focus group all converged on the fact that medical education is not adequate and guidelines for an adequate course were proposed, the courses available did not meet the quality criteria established.
Conclusions: Even though Colombia has the legal framework to produce and prescribe medical cannabis, its doctors are not prepared academically to do so. This subject should be strengthened and included in the medical pensum of the different local universities.
Allogeneic hematopoietic stem cell transplantation and pre-transplant strategies in patients with NPM1-mutated acute myeloid leukemia – a single center experience –
Authors: Jäger Paul , Rautenberg Christina , Kaivers Jennifer , Kasprzak Annika , Geyh Stefanie , Baermann Ben-Niklas , Haas Rainer , Germing Ulrich , Schroeder Thomas , Kobbe Guido
Published: April 2023

Patients with acute myeloid leukemia (AML) and nucleophosmin 1 gene mutations (NPM1mut) show a favorable prognosis with chemotherapy (CT) in the absence of negative prognostic genetic abnormalities. Between 2008 and 2021 64 patients with NPM1mutAML received alloHSCT because of additional adverse prognostic factors (1st line), inadequate response to or relapse during or after CT (2nd line). To expand the evidence in alloTX in NPM1mut AML, clinical and molecular data were retrospectively analyzed with respect to pre-transplant strategies and outcome. Patients with minimal residual disease negative (MRD-) CR at transplant had better 2-y-PFS and 2-y-OS (77% and 88%) than patients with minimal residual disease positive (MRD+) CR (41% and 71%) or patients with active disease (AD) at transplant (20% and 52%). The 2nd line patients with relapse after completing CT responded well to high dose cytarabine based salvage chemotherapy (salvage CT) in contrast to patients relapsing while still on CT (90% vs 20%, p = 0.0170). 2-y-PFS and 2-y-OS was 86% in patients who achieved a 2nd MRD- CR pre alloHSCT. Outcome in NPM1mutAML depends on disease burden at alloHSCT. Time and type of relapse in relation to CT are predictive for response to salvage CT.
Relapse rate and predictors of relapse after cessation of glucocorticoid maintenance therapy in type 1 autoimmune pancreatitis: a multicenter retrospective study
Authors: Kiyoshita Yusuke , Ishii Yasutaka , Serikawa Masahiro , Hanada Keiji , Sasaki Tamito , Fujimoto Yoshifumi , Yamaguchi Atsushi , Hirao Ken , Noma Bunjiro , Minami Tomoyuki , Okazaki Akihito , Yukutake Masanobu , Mouri Teruo , Tsuboi Tomofumi , Tatsukawa Yumiko , Nakamura Shinya , Hirano Tetsuro , Ikemoto Juri , Saeki Sho , Tamura Yosuke , Miyamoto Sayaka , Furukawa Masaru , Nakmura Kazuki , Yamashita Yumiko , Iijima Noriaki , Oka Shiro
Published: April 2023

Background:
Type 1 autoimmune pancreatitis responds well to glucocorticoid therapy with a high remission rate. Moreover, glucocorticoid maintenance therapy can help prevent relapse. However, the relapse rate following cessation of long-term glucocorticoid therapy is unknown. The aim of this study was to clarify the relapse rate and predictors of relapse following long-term glucocorticoid therapy cessation.
Methods:
We analyzed 94 patients who achieved remission after undergoing glucocorticoid therapy, discontinued treatment after at least 6 months of maintenance therapy, and were subsequently followed up for at least 6 months. The patients were divided into three groups based on treatment duration (< 18, 18–36, and ≥ 36 months), and their relapse rates were compared. Univariate and multivariate analyses of clinical factors were conducted to identify relapse predictors.
Results:
After discontinuing glucocorticoid therapy, relapse was observed in 43 (45.7%) patients, with cumulative relapse rates of 28.2% at 1 year, 42.1% at 3 years, 47.0% at 5 years, and a plateau of 77.6% at 9 years. Of the 43 patients who relapsed, 25 (58.1%) relapsed within 1 year after after cessation of glucocorticoid therapy. Relapse and cumulative relapse rates did not differ significantly according to treatment duration. In the multivariate analysis, an elevated serum IgG4 level at the time of glucocorticoid cessation was found to be an independent predictor of relapse (hazard ratio, 3.351; p = 0.005).
Conclusions:
A high relapse rate occurred after cessation of glucocorticoid maintenance therapy, regardless of the duration of maintenance therapy, especially within the first year after cessation. However, the normalization of long-term serum IgG4 levels may be a factor in considering cessation.
WITHDRAWN: Effect of Hypothalamic Adrenal Axis and Thyroid Function Alterations on Prognosis of Critically Ill Covid-19 Patients
Authors: Korkusuz Muhammet , Karaburgu Sulbiye , Et Tayfun , Yarımoglu Rafet , Kumru Nuh
Published: April 2023

Purpose: The aim of this study was to evaluate the changes in adrenal, and thyroid functions on the prognosis of COVID-19 patients admitted to the intensive care unit (ICU).
Methods:This was a retrospective evaluation that included COVID-19 patients requiring ICU admission. Serum cortisol, adrenocorticotrophic hormone (ACTH), thyroid-stimulating hormone (TSH), free thyroxine (fT4) and triiodothyronine (fT3) levels were measured on admission and two more times during the hospitalization. Routine biochemistry, hemogram, C-reactive protein, procalcitonin, fibrinogen and D-dimer levels were also measured, along with hormones.All-cause mortality during ICU stay, inotropic drug and mechanical ventilation needs, and duration of hospitalization were recorded for each patient. Euthyroid sick syndrome (ESS) and hypocortisolism rates were determined. Deceased and survivor patients were compared in terms of hormone values, and logistic regression to determine independent associates of mortality were performed.
Results: Overall, 124 patients (58% male, mean age 70.7±11.3 years) were included. During the ICU stay, both fT3 and fT4, but not TSH, showed a statistically significant decrease compared to admission values. Serum cortisol and ACTH values increased compared to admission values, this increase was not significant. ESS was present in 89.5% of the patients. Two-thirds of the patients died in ICU. Serum fT3 values were significantly lower among decedents compared to survivors. Hypocortisolism was detected in 20.1% of the patients. Only the fT3 level could independently and significantly predict all-cause mortality.
Conclusion:ESS was almost universal among critically ill COVID-19 patients. Serum fT3, but not other thyroid or adrenal hormones, could significantly predict all-cause mortality.
Trial registration number: 02-2020/04
Date of registration: 07/12/2020
Mitochondrial Health Index Correlates with Plasma Circulating Cell-Free Mitochondrial DNA in Bipolar Disorder
Authors: Scaini Giselli , Cordeiro Rafaela , Lima Camila Carvalho , Fries Gabriel , Zunta-Soares Giovana , Soares Jair C. , de Quevedo Joao
Published: April 2023

Background: Although mitochondria dysfunction is known to play an essential role in the pathophysiology of bipolar disorder (BD), there is a glaring gap in our understanding of how mitochondrial dysfunction can modulate clinical phenotypes. This study aimed to evaluate the composite mitochondrial health index (MHI) in BD subjects and non-psychiatry controls (Non-psychiatry controls). We will also explore whether lower MIH will be related to higher cell-free mtDNA (ccf-mtDNA) levels and poor clinical outcomes.
Methods: Fourteen BD-I patients and 16 age- and sex-matched non-psychiatry controls were enrolled for this study. Peripheral blood mononuclear cells (PBMCs) were used to measure the enzymatic activities of citrate synthase and complexes I, II, and IV and mtDNA copy number. ccf-mtDNA was evaluated by qPCR in plasma. Mitochondrial quality control (MQC) proteins were evaluated by western blotting.
Results: One-Way ANCOVA after controlling for age, sex, body mass index (BMI), and smoking status showed that patients with BD present a decrease in the MHI compared to non-psychiatry controls, and higher ccf-mtDNA levels, which was negatively correlated with MHI. Because the MQC network is essential to maintain mitochondrial health, we also evaluated the relationship between MQC-related proteins with MHI and ccf-mtDNA. Our results showed that MHI negatively correlated with Fis-1 and positively with Opa-1 and LC3. Moreover, we found a negative correlation between ccf-mtDNA, Opa-1, and LC3 and a positive correlation between cff-mtDNA and Fis-1. Finally, we found that subjects with longer illness duration, higher depressive symptom scores, and worse functional status had lower MHI and higher ccf-mtDNA.
Conclusion: In summary, the present findings corroborate previous studies and provide strong support for the hypothesis that mitochondrial regulation and function are integral parts of the pathogenesis of BD.
Prototypical Latent Space Regularization for Improved Reconstruction Quality in Variational Autoencoders
Authors: Oliveira Dario Augusto Borges , Rosa Laura Elena Cue La
Published: April 2023

Variational autoencoders use latent space regularization with known distributions to facilitate stochastic synthesis via simple sampling procedures. However, existing regularization approaches often struggle to balance regularization and reconstruction quality effectively. To address this, we propose a distributed latent space regularization approach using prototypical deep clustering with known distributions. Our method achieves high-quality data synthesis by decoding samples around prototypes, without the need for auxiliary networks to explicitly learn decoder synthesis from codes. Our approach enables obtaining an appropriate number of clusters for solid regularization with better reconstruction quality and improved synthesis control. Through widespread exploratory benchmarks, we demonstrate that our regularization centered on optimal prototypes' coordinates or cluster centroids neutralizes the adverse effects of regularization terms on autoencoder reconstruction quality, matching non-regularized autoencoders' performance. Additionally, we report promising results for interpreting data representatives via simple prototype synthesis and controlling the synthesis of samples with prototype-like characteristics by decoding noise around prototype coordinates using known distributions.
Ceramic Art Image Design Based on Neural Network and Particle Image Algorithm
Authors: Zhang Lijian , Liu Guangfu
Published: April 2023

In recent years, scientists have developed a new type of algorithm called convolutional neural network algorithm in the field of neural networks. This algorithm not only has a powerful image recognition function, but also can distinguish and arrange data images. At the same time, the algorithm's recognition and processing functions are also very powerful, able to identify relatively hidden images and process a very large image library in a short time. The research content of this article is the application and development of ceramic image creation based on the classification effect of neural network and the characteristics of quantum particle swarm algorithm. And according to the principles, standards, characteristics of neural network classification and the characteristics and technology of particle swarm algorithm, the traditional LB G algorithm and an improved LB G algorithm are discussed, and simulation experiments are carried out. During the experiment, the staff analyzed and optimized the specific process of the quantum particle swarm algorithm through a large number of calculations and simulation experiments. And according to the classification of neural network and quantum particle swarm algorithm, the researchers also proposed a set of practical ceramic image design methods. Through the inspection and comparison of the design results, the researchers preliminarily judged that the design method is not only practical, but also high Many advantages such as recognition, high accuracy and good visual experience. At the same time, the staff also optimized the method based on the preliminary design results.
Environmental Resource Allocation and Online English Teaching Based on Voice Dialogue System
Authors: Wang Panpan
Published: April 2023

In speech conversation systems, the specific distribution of computing resources is very complex, and resource requirements exhibit dynamic changes. If the evaluation of customer needs is too low, computing resources cannot complete the work proposed by the customer; If customer demand is overestimated, many computing resources are wasted and idle, and a reasonable environmental resource allocation algorithm is the top priority in solving the problem. As mankind enters the information modernization society, multimedia technology and Internet technology are increasingly being widely used in various fields of society, including online teaching. In lifelong learning systems, online English teaching is now an essential learning method. However, online learning has been widely used in the world. When engaging in online learning activities, it is found that there are insufficient systematic research and low participation in learning. People can access a large number of very rich learning resources on the Internet. In the online learning process, learners can fully exert their autonomy and initiative to cultivate and expand their own innovation and practical abilities. When participating in the learning process of online courses, learners can not only develop themselves, but also strengthen effective coordination and communication with others and society, enabling them to coordinate the development of all aspects of their own abilities, improving learning effectiveness and efficiency. This article aims to promote the better development of online English teaching through the research on environmental resource allocation based on voice dialogue systems and its application to online English teaching.
Cloud computing-based online video sports course management
Authors: Liu Qiao
Published: April 2023

This paper designs a kind of effective online video system by introducing cloud computing technology into the field of sports course management. The main idea is to use the attention network mechanism to obtain the characteristics of the target course and use the recommendation algorithm to calculate the accurate recommendation for the user. In this process, the course vector and user features obtained through the model can be stored and compiled by the system, and a course recommendation system database can be constructed. Then, a system engine is designed based on clustering implicit vectors and course data, which can make personalized recommendation based on different application scenarios and users, thus providing data support for system course recommendation. Finally, the platform requirements of online video teaching practice are investigated, and the demonstration object of online teaching practice is proposed; The system is mainly equipped with user information and authority management, live video teaching management and video-on-demand teaching management, teaching video album management, teaching evaluation online course management, teaching and research interaction, examination management and other functions, and its microservice division is completed in distributed cloud computing. implemented in the service.. A series of tests have confirmed the effectiveness of the platform, which has a certain reference value for improving the effect of physical education teaching and improving the effect of students' physical education.
Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector
Authors: Kise Satoko , Iijima Ayano , Nagao Chika , Okada Tadashi , Nishikawa Miyu , Ikushiro Shinichi , Nakanishi Tomoko , Sato Shigeto , Yasuda Kaori , Sakaki Toshiyuki
Published: April 2023

Type II rickets is a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. The main symptoms of this disease are bone dysplasia and alopecia. Bone dysplasia can be ameliorated by high calcium intake; however, there is no suitable treatment for alopecia. In this study, we verified whether gene therapy using an adenoviral vector (AdV) had a therapeutic effect on alopecia in Vdr-KO rats. The VDR-expressing AdV was injected into six 7-week-old female Vdr-KO rats (VDR-AdV rats). On the other hand, control-AdV was injected into 7-week-old female rats (control-AdV rats); non-infected Vdr-KO rats (control rats) were also examined. The hair on the backs of the rats was shaved with hair clippers, and VDR-AdV or control-AdV was intradermally injected. Part of the back skin was collected from each rat after AdV administration. Hair follicles were observed using hematoxylin and eosin staining, and VDR expression was examined using immunostaining and western blotting. VDR-AdV rats showed significant VDR expression in the skin, enhanced hair growth, and low cyst formation, whereas control-AdV and non-infected rats did not show any of these effects. These results indicate that gene therapy is useful to treat alopecia associated with type II rickets.
‘Rebuilding Myself’- An intervention enhancing the adaptability of cancer patients to return to work: protocol of a randomized controlled trial.
Authors: Tang Jue , SANG Honghua , QUE Wenqian , ZHAO Jingyi , SU Xiaoqin , KUAI Benxin , SHI Yue , GUO Yujie
Published: April 2023

Aim: To describe a protocol that explores the feasibility and effectiveness of an intervention enhancing the adaptability of cancer patients to return to work.
Background: Current evidence suggests the situation of cancer patients returning to work in China is unsatisfactory. Based on the ‘Adaptation Experience and Coping Resource Model for cancer patients to return to work’, we designed an intervention protocol.
Design: A two-armed non-blinded randomized controlled trial.
Methods: 96 participants will be recruited from three hospitals and the Cancer Rehabilitation Association in Nantong. After signing the informed consent form and completing the baseline assessment questionnaire, patients will be randomly assigned to either the intervention or control group at a ratio of 1:1. The primary outcome is the adaptability to return to work. The secondary outcomes are the self-efficacy of returning to work, mental resilience, quality of life, and work ability.
Discussion: This study is to design a protocol for the ‘Rebuilding Myself’ intervention to enhance the adaptability of cancer patients to return to work. This study will provide new insights into the feasibility and effectiveness of the intervention. We anticipate that cancer patients will benefit from this study.
Impact: This study will guide for researchers to carry out interventions enhancing cancer patients’ adaptability to return to work. If proven feasible and practical, it will be carried out broadly.
Trial registration: This study was registered at the Chinese Clinical Trial Registry (Registration number: ChiCTR2200057943) on 23 March, 2022.
The ever wider clinical spectrum of RMND1-related disorders and limitedness of phenotype-based classifications
Authors: Rioux Alexis V. , Riopel Julie , Marcoux Nicolas , Thériault Catherine , Gould Peter V. , Garneau Alexandre P. , Isenring Paul
Published: April 2023

RMND1 has been identified as a mitochondriopathy-associated gene less than 12 years ago. The most common phenotype related to this gene is an early onset, severe form of encephalomyopathy that leads to death in a medium time of three years after birth. However, milder and later onset presentations have been reported in some individuals, including two in whom the mitochondriopathy was identified at ~ 40 years of age, and the early onset presentations have been the object of no reports in those who survived beyond age 10. It is thus unclear how lethal RMND1-related conditions really are. We herein describe the oldest case to have been identified hitherto with this condition, i.e., that of a white female who was 61 at the time of diagnosis but was still active in her everyday life. The gene defect identified was nonetheless associated with many manifestations including ovarian insufficiency and sensorineural hearing loss (two features of what is currently designated as Perrault syndrome) as well as chronic renal failure, asymptomatic myopathy, leukopenia and a few others. In our opinion, this case is of great translational interest for at least three reasons. First, it hints towards the possibility of near-normal life expectancies in some if not many individuals with RMND1 insufficiency. Second, it underlines the wide clinical spectrum associated with this gene. Third, it brings us to question the use of eponyms and syndromic features to identify the true etiology of multisystemic phenotypes.
Enteral L-citrulline supplementation in preterm infants is safe and effective in increasing plasma arginine and citrulline levels – A pilot randomized-controlled trial
Authors: Jain Sunil , Qasim Amna , Bhatia Snigdha , Fuenmayor Maria Franco , Mehdi Mohammad
Published: April 2023

Objective
Deficiencies of citrulline and arginine have been associated with adverse outcomes in preterm-infants (PI) and data regarding enteral supplementation in PI is unknown.
Study Design:
This randomized-controlled-trial [NCT03649932] included 42 PI (gestational age ≤ 33 weeks) randomized to receive enteral L-citrulline in low (100 mg/kg/day), medium (200 mg/kg/day) and high-dose (300 mg/kg/day) groups for 7 days. Plasma citrulline and arginine levels were obtained pre-and-post supplementation and efficacy was determined by a significant increase in levels after supplementation. A p < 0.05 was considered significant. Safety monitoring included blood-pressure-monitoring as well as complications and death during hospitalization.
Results
A total of 40/42 (95%) of the recruits completed the 7-day supplementation with no adverse events. Plasma-citrulline levels increased significantly in all 3 groups while plasma-arginine levels increased significantly in the medium and high-dose groups.
Conclusion
Enteral L-citrulline supplementation in PI is safe and effective in increasing plasma citrulline and arginine levels.
High-Gain Printed Monopole Antenna with Dual-Band Characteristics using FSS- Loading and Top-Hat Structure
Authors: Danuor Patrick , Jung Young-Bae , Moon Jung-Ick
Published: April 2023

This paper presents a high-gain printed monopole antenna with dual-band omnidirectional radiation pattern characteristics for applications in WLAN and IoT sensor networks. The antenna is loaded with a layer of frequency selective surface (FSS) unit cells and a top-hat structure which is seated on top of the dielectric substrate. The proposed antenna structure realizes a high gain without compromising the omnidirectional radiation patterns within the antenna’s operating band. A prototype of the proposed antenna is fabricated where good agreement is achieved between the measured and full-wave simulation results. The proposed antenna attains an impedance bandwidth |S11| < -10 dB at 1.6–2.1 GHz and 2.4–2.85 GHz with a measured peak gain of 5.2 dBi and 6.1 dBi, respectively.
A novel biomarker for Ataxia-Telangiectasia: Evaluating the lack of hypointensity of the dentate nuclei
Authors: Tiet May Yung , Scoffings Daniel J , Blanchard Caroline , Dineen Robert A , Horvath Rita , Hensiek Anke E
Published: April 2023

Ataxia-Telangiectasia (A-T) is a very rare autosomal recessive disease characterised by cerebellar ataxia, extrapyramidal movements and cancer predisposition. Delayed diagnosis is common due to clinical heterogeneity. The development of clinical trials in A-T is limited by a lack of suitable biomarkers. Abnormal hypointensity of the dentate nuclei (DN) has been demonstrated in some genetic ataxias. We assess the degree of hypointensity of the DN in paediatric and adult A-T patients using the Gupta visual ranking score and report a novel observation of a lack of hypointensity of the DN in adults. Adult A-T patients had significantly lower visual rating scores than paediatric patients (0.07 versus 0.55 respectively). Our findings demonstrate that the normal process leading to hypointensity of the DN is initiated in children with A-T, but the physiological DN hypointensity is lost by adulthood.
Preparation of porous silica materials using a eucalyptus template method and its efficient adsorption of methylene blue
Authors: Zhu Wenxin , Liu Leping , Lao YuanXia , He Yan
Published: April 2023

Mesoporous silica has become one of the primary adsorbent materials for solving dye wastewater pollution due to its high specific surface area and good adsorption properties. However, the high cost of the traditional chemical synthesis method limits its wide application. In this thesis, low-cost and high-efficiency porous silica adsorbent materials (PSAM) were successfully prepared by dissolving quartz powder in NaOH solution and depositing and growing in the pores of eucalyptus wood under hydrothermal conditions using eucalyptus wood as a templating agent. The experimental results showed the prepared materials have a loose, porous slit pore structure and many active adsorption sites. The adsorption efficiency of methylene blue was high, reaching more than 85% within 10 min, and the maximum adsorption amount was 90.01 mg/g. The adsorption process was by the pseudo-first-order，pseudo-second-order, and Langmuir models. The analysis of thermodynamic data showed that the adsorption of methylene blue by PSAM was a heat-absorbing process and spontaneous. Therefore, PSAM can be effectively used for the application of methylene blue dye removal in water.
WITHDRAWN: Exploring the features of quanvolutional neural networks for improved image classification
Authors: Tuan Hai Vu , Le Lawrence H , The Bao Pham
Published: April 2023

In several machine learning applications, image classification is a crucial problem. Numerous classification techniques based on quantum machine learning have been presented recently. In this article, we investigate the features of the quanvolutional neural network - a hybrid quantum-classical image classification technique inspired by the convolutional neural network which has the potential to outperform current image processing techniques. We improve the training strategy and evaluate the classification tasks on traditional datasets by different topologies, sizes, and depth of filters. Finally, we propose an efficient configuration for the quanvolutional neural network, making it a promising solution for image classification problems.
Interfacial thermal transport of carbon nanotube on substrate
Authors: Chen Jiao , Hu Baoyi , Wang Zhaoliang
Published: April 2023

Exploring the thermal transport properties of the interface structure of low-dimensional nanomaterials contributes to a deeper understanding of the interface phonon modes and may provide theoretical support for efficient chip cooling devices. In this manuscript, we have simulated in detail the effects of system temperature, substrate location and heat flow density on the thermal transport at the SWCNT/Si interface using the Non-equilibrium Molecular Dynamics approach and predicted the interfacial thermal conductance of SWCNT/Si for second, third and fourth order phonon using the Anharmonic Inelastic model. The results show that the low-frequency acoustic branch of SWCNT is suppressed by phonon scattering from the substrate, and the low-frequency phonon branch of SWCNT is boosted by about 1 THz. The anharmonic channels and inelastic phonon scattering significantly affect the interface phonon modes at higher temperatures, and the anharmonic interactions could increase additional thermal transport channels, which result in an increased number of additional phonon peaks. The increase in temperature gradually consumes the phonons incident at the interface in SWCNT, which enhances the anharmonic scattering and weakens the nonlinear characteristics of the bimaterial heterostructure, while the weakening of the acoustic branch accompanied by the temperature increase makes the LA phonon branch thermal conduction rate slower and the interfacial thermal conductance gradually stabilizes, which leads to the weakening of the thermal rectification effect.