bluuebunny/crossref_metadata_2025 huggingface dataset:
Percutaneous tracheostomy procedures and patient results in a tertiary intensive care unit: A single-center experience
Authors: Vahapoğlu Ayşe , Kaya Gök Ayfer , Çavuş Zuhal
Published: February 2025

The ideal timing for tracheostomy in patients undergoing prolonged mechanical ventilation (MV) in the intensive care unit (ICU) remains controversial. The present study aimed to provide an overview of the timing of percutaneous dilation tracheostomy performed in the ICU over a 5-year period, and the effect of this procedure on 28-day mortality. The study included patients who underwent early (≤14 days) (n = 112) and late (>14 days) (n = 171) tracheostomy during their follow-up in the ICU between 2018 and 2023. It is a single-center retrospective study. The diagnoses, comorbidities, MV duration, tracheostomy timing, tracheostomy indications, tracheostomy complications, ICU length of stay, hospital length of stay, extubation attempts, mortality, time to decannulation, and ICU discharge location were determined in both tracheostomy groups and compared. The effect of tracheostomy timing on mortality risk was evaluated using multivariate Cox regression analyses. In the early tracheostomy group, MV duration, ICU hospitalization, hospital stay, and extubation attempt were lower. The 28-day intensive care mortality rates were not statistically different between the early and late tracheostomy groups. Multivariate regression analysis showed that mortality risk increased with prolonged MV and tracheostomy complications. In terms of mortality rates in palliative care, mortality in the late tracheostomy group was significantly lower than in the early tracheostomy group. The study demonstrated that the timing of tracheostomy in the ICU had no effect on mortality risk in multivariate analysis. We believe that time is not the only limiting factor when considering tracheostomy and prospective randomized studies are needed.
Long-term ocular sequelae in preterm Thai infants: A comprehensive retrospective study
Authors: Srimanan Worapot , Kitsirilarp Warissara
Published: February 2025

Prematurity can lead to various ocular conditions, including strabismus, refractive errors, amblyopia, and cataracts. However, comprehensive data on these outcomes in preterm Thai infants is limited. This study aimed to investigate the incidence of retinopathy of prematurity (ROP) and assess long-term ocular sequelae, such as cataracts, refractive errors, strabismus, and amblyopia, among preterm infants at Phramongkutklao Hospital. A retrospective review of medical records was conducted for premature infants screened for ROP between January 2011 and April 2022. Data were collected at birth, and follow-up visits were analyzed at 6 months, 1 year, and 2 years of age. The primary outcomes included the incidence of ROP and the prevalence of long-term ocular sequelae. A total of 308 preterm infants were included in the study. The incidence of ROP was found to be 31.5%. At the 2-year follow-up, the prevalence of cataracts was 0.65%, strabismus 14.4%, and amblyopia 6%. Refractive errors were observed in 51.8% of the infants, with 18.1% showing myopia and 33.7% hyperopia. Logistic regression analysis indicated that delayed growth and development (adjusted odds ratio = 13.28, 95% confidence interval: 1.83–96.68) and amblyopia (adjusted odds ratio = 19.65, 95% confidence interval: 2.85–135.54) were significantly associated with an increased risk of developing strabismus, after adjusting for confounding factors. The study identified an ROP incidence of 31.5% in the preterm cohort. At 2 years, long-term ocular sequelae included a prevalence of cataracts (0.65%), strabismus (14.4%), amblyopia (6%), and refractive errors (51.8%). Delayed growth and development, along with amblyopia, were found to elevate the risk of strabismus development significantly.
Afipia dichlorophenoxyacetatis sp. nov., isolated from field soil in Japan, degrades 2,4-dichlorophenoxyacetic acid
Authors: Sawada Hiroyuki , Sakai Yoriko , Takashima Yusuke , Naito Ken , Horita Mitsuo , Satou Mamoru
Published: February 2025

Bacterial strains, designated DD3T and DDX28, were isolated from field soil in Japan. The strains had the ability to use 2,4-dichlorophenoxyacetic acid as the sole carbon source. They were Gram-reaction-negative, oxidase-positive, weakly catalase-positive, aerobic and non-spore-forming. Their cells were rod-shaped and often lacked flagella, but some exhibited motility due to the presence of one or two polar flagella. The genomic DNA G+C content was 58.8 mol%, and the major cellular fatty acids (>10% of the total fatty acids) were summed feature 8 (C18 : 1
 ω7c and/or C18 : 1
 ω6c), C18 : 0 and C17 : 0 cyclo. Phylogenetic analyses based on gyrB gene sequences and phylogenomic analysis using whole-genome sequences confirmed that the strains belong to the genus Afipia; however, their phylogenetic position did not match that of any known species of this genus. Comparative studies of the average nucleotide identity and digital DNA–DNA hybridization with closely related species revealed values lower than the thresholds used for prokaryotic species delineation (95–96 and 70%, respectively), with the highest values observed for Afipia broomeae ATCC 49717T (79.92 and 21.5%, respectively). Phenotypic characteristics, cellular fatty acid composition and specific metabolic processes and biosynthetic gene clusters could differentiate the strains from their closest relatives. Our phenotypic, chemotaxonomic and genotypic data indicate that DD3T/DDX28 constitute a novel Afipia species, for which we propose the name Afipia dichlorophenoxyacetatis sp. nov., with DD3T (MAFF 311804T=ICMP 25015T) as the type strain.
The EMCV protein 2B* is required for efficient cell lysis via both caspase-3-dependent and -independent pathways during infection
Authors: Nguyen Samantha K. , Long Edward , Edgar James R. , Firth Andrew E. , Stewart Hazel
Published: February 2025

2B* is a poorly characterized protein encoded by an overlapping ORF in the genome of encephalomyocarditis virus (EMCV). We have previously found 2B* to have a role in innate immune antagonism; however, this role is distinct from an earlier described phenotype whereby 2B*KO viruses exhibit extremely small plaques compared to WT. Here, we report that the small plaque phenotype is recapitulated by novel EMCV mutant viruses harbouring mutations across the C-terminal domain of 2B*, confirming a functional role of 2B* in promoting viral spread. We found that 2B*KO EMCV displays impaired extracellular virus titres compared to WT EMCV, despite producing a similar number of infectious particles overall. This correlates with a reduction in cell lysis and lower levels of caspase-3 cleavage occurring during infection. Further investigation using caspase inhibitors and knockout cells revealed that WT EMCV can utilize both caspase-3-dependent and caspase-3-independent pathways to achieve cell lysis, the former of which is likely to be GSDME-mediated pyroptosis. 2B* increases the efficiency of both lytic pathways through an as-yet-undefined mechanism. This work reveals 2B*, a protein only found in EMCV, to be a key regulator of multiple lytic cell death pathways, leading to enhanced rates of virus release. This explains the rapid cell death observed during WT EMCV infection and the small plaque phenotype seen in both 2B*KO and previously described 2B* mutant viruses.
Evaluation of reproductive profiles, epigenetic aging, and mortality in post-menopausal women
Authors: Ye Qiaofeng , Ahamed Aaliya , Shalev Idan , Etzel Laura
Published: February 2025

Evolutionary theories of aging indicate trade-offs between reproduction and longevity. Epigenetic clocks, such as PhenoAge, GrimAge, and DunedinPoAm, were designed to reflect biological age and be used as surrogates for mortality and healthspan. The current study investigated the connection between reproductive profiles, epigenetic aging and mortality among post-menopausal women (50-85 years) with data from the National Health and Nutrition Examination Survey across the United States (N=770). Using latent profile analysis, we identified four distinct reproductive profiles: high gravidity but average parity (Class 1); high gravidity and parity (Class 2); early menopause (Class 3); an average profile (Class 4). Women of Class 3 had an accelerated pace of aging as indicated by DunedinPoAm, but not an older epigenetic age as measured by PhenoAge or GrimAge. The association was significant among women who had ever used female hormones (β=0.521; 95%CI 0.014-1.027). Women of Class 1 or 2 did not exhibit accelerated epigenetic aging. Women of Class 3 had higher mortality (HR=1.40, 95%CI 1.08-1.81), and 36.3% of the effect was mediated through accelerated DunedinPoAm. Findings suggest that women with reproductive profiles characterized by early menopause may have altered epigenetic aging trajectories. Pace of aging may be more sensitive to the impact of reproductive profile variations than the status of biological age as indicated by PhenoAge or GrimAge. Clinically monitoring the pace of biological aging among women with early menopause and an appropriate application of hormone replacement therapy may minimize the negative consequence of accelerated biological aging and reduce premature mortality.
Decoding yeast transcriptional regulation via a data-and mechanism-driven distributed large-scale network model
Authors: Fan Xingcun , Xiang Guangming , Liao Wenbin , Xiao Luchi , He Siwei , Lu Hongzhong , Yan Xuefeng
Published: February 2025

The complex transcriptional regulatory relationships among genes influence gene expression levels and play crucial roles in determining cellular phenotypes. Here, we present a novel distributed large-scale transcriptional regulatory neural network model (DLTRNM) by integrating prior knowledge into the reconstruction of pre-trained machine learning models followed with fine-tuning. TakenS. cerevisiaeas the example, the transcriptional regulatory relationships, carefully compiled and documented, are utilized to define interactions between TFs and their TGs within DLTRNM. Subsequently, DLTRNM is pre-trained on pan-transcriptomic data and fine-tuned with time-series data, enabling it to accurately predict dynamic regulatory correlations between TFs and TGs, such as simulating TG responses by tuning the expression of TFs. In addition, DLTRNM can assist in identifying potential key TFs for a subset of genes, thus simplifying the complex and interrelated transcriptional regulatory networks (TRN). Based on the key TFs, it can also refine previously reported transcriptional regulatory subnetworks and highlight the core regulatory networks. DLTRNM offers a powerful tool for studying transcriptional regulation with reduced computational demands and enhanced interpretability. Thus, this study represents a significant step forward in systems biology for understanding the complicated transcriptional regulation within cells.
Molecular bases for the loss of type VI secretion system activity during enteroaggregativeE. coliexperimental evolution
Authors: Taillefer Boris , Desjardins Jonas B. , Cascales Eric
Published: February 2025

The type VI secretion system (T6SS) is a nanoweapon deployed by Gram-negative to inject effectors into target cells and hence involved in pathogenesis and bacterial competition. While T6SS gene clusters are found in all recently isolated commensals or pathogenicEscherichia colistrains, they are absent from classical laboratory strains. TheseE. colistrains, which have been used since decades for bacterial genetics, were usually grown in pure cultures, suggesting that T6SS might have been lost during evolution in absence of competitors. Here, we conducted a 640-generation experimental evolution by passaging the enteroaggregativeE. coli(EAEC) 17-2 strain under controlled competition conditions against susceptible or immune recipient cells. EAEC T6SS activity was almost abolished when grown in the presence of immune recipients, while no difference with the ancestral strain was observed for EAEC grown in the presence of susceptible cells. Whole genome sequencing of 18 clones identified adaptative mutations responsible for the loss of T6SS activity, including mutations of the T6SS promoter and within genes encoding T6SS subunits, and revealed a novel regulatory mechanism involving RfaH-dependent antitermination. We further found that the RfaH binding siteopselement is present in T6SS gene clusters of several species, suggesting a conserved RfaH-dependent regulation of T6SSs across enterobacteria. This work exemplifies the power of experimental evolution to understand T6SS genetic adaptation and to unravel new players for its function.
Quantum simulation in hybrid transmission lines
Authors: Ferreri Alessandro , Wilhelm Frank K.
Published: February 2025

Platforms based on transmission lines are nowadays employed for the simulation of standard phenomena in quantum electrodynamics and quantum field theory. In this work, we propose a hybrid platform, in which a right-handed transmission line is connected to a left-handed transmission line by means of a superconducting quantum interference device. We examine the interaction between the two transmission lines, as well as the excitation flow along the composite platform. We show that, by activating specific resonance conditions, this platform can be used as a quantum simulator of different phenomena in quantum optics, multimode quantum systems, and quantum thermodynamics.

Published by the American Physical Society
2025
Hadamard regularization of the graviton stress tensor
Authors: Negro Anna , Patil Subodh P.
Published: February 2025

We present the details for the covariant renormalization of the stress tensor for vacuum tensor perturbations at the level of the effective action, adopting Hadamard regularization techniques to isolate short distance divergences and gauge fixing via the Faddeev-Popov procedure. The subsequently derived renormalized stress tensor can be related to more familiar forms reliant upon an averaging prescription, such as the Isaacson or Misner-Thorne-Wheeler forms. The latter, however, are premised on a prior scale separation (beyond which the averaging is invoked) and therefore unsuited for the purposes of renormalization. This can lead to potentially unphysical conclusions when taken as a starting point for the computation of any observable that needs regularization, such as the energy density associated to a stochastic background. Any averaging prescription, if needed, should only be invoked at the end of the renormalization procedure. The latter necessarily involves the imposition of renormalization conditions via a physical measurement at some fixed scale, which we retrace for primordial gravitational waves sourced from vacuum fluctuations through direct or indirect observation.

Published by the American Physical Society
2025
The use of management information in process innovation: effects of knowledge conversion by socialization
Authors: Beuren Ilse Maria , Meurer Silvana Mannes , Ferraz Pazetto Celliane
Published: February 2025

Purpose

The article analyzes the effects of using management information and knowledge conversion by socialization in process innovation.

Design/methodology/approach

A survey was conducted with 133 managers of Brazilian firms that received tax subsidies to develop technological innovation. For data analysis, structural equation modeling was used.

Findings

Results show that the use of management information to score keeping and focusing organizational attention triggered higher levels of process innovation. In contrast, improving understanding and improving organizational learning did not show statistical significance, suggesting that these do not have the potential to influence directly process innovation. It was also found that managers’ skill to convert knowledge by socialization precedes process innovation. Furthermore, mediating effect of knowledge conversion by socialization between the use of management information and process innovation was statistically significant only in improving organizational learning.

Practical implications

The finding that the use of management information for score keeping, focusing organizational attention directly and improving organizational learning indirectly reflects in higher levels of innovation can be used as part of the strategy and support organization’s management in process innovation. Furthermore, the organization can emphasize on knowledge conversion by socialization, both explicit and tacit knowledge, to leverage process innovation.

Originality/value

The study addresses recent calls to understand the potential of managers’ skills to convert knowledge through socialization. Evidence shows that, by socializing knowledge, managers expand and disseminate the organization’s tacit knowledge, which can stimulate process innovation. It also adds to the debate about which uses of information managers should emphasize to promote process innovation.
The great pretending: artistic logic for entrepreneurial action
Authors: Sigurdarson Hallur Thor , Candi Marina , Dimov Dimo
Published: February 2025

Purpose

We propose an artistic logic of entrepreneurial action whereby individuals undertake entrepreneurial acts even without entrepreneurial intentions, creating a pretended reality through performance-like processes. We explore how these actions impact real-world entrepreneurship, challenging conventional venture creation and evaluation paradigms.

Design/methodology/approach

Artistic logic is developed and illustrated through an in-depth analysis of a qualitative case study of a pretend airline employing a constructivist-interpretive approach.

Findings

We identify four dimensions of artistic logic in entrepreneurial action, which underscore the capacity of artistic entrepreneurial performances to simulate real entrepreneurial experiences: leveraging a socio-economic situation, building an evocative image of a venture, attracting engagement and pretending.

Practical implications

The findings have significant implications for venture creation, offering entrepreneurs a framework for conducting expansive prototyping to develop, evaluate and actualise opportunities. Additionally, the findings can enrich entrepreneurial education by highlighting the value of expansive prototyping that immerses student entrepreneurs in the opportunity as a creative process.

Originality/value

Framing entrepreneurial action within the context of performance art as artistic logic bridges theoretical gaps between creativity, subversion and entrepreneurship, offering a novel perspective on venture simulation, creation and opportunity evaluation.
The evolution of cybersecurity in self-driving cars: insights from bibliometric research
Authors: Dias Lousã Mário , Teixeira Henrique , Pereira de Morais José Carlos
Published: February 2025

Purpose

This study aims to investigate the evolution of cybersecurity in autonomous vehicles over the past decade, focusing on influential publications, leading authors, key themes and emerging research trends.

Design/methodology/approach

A systematic literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach, with data extracted from The Lens database and analyzed using VOSviewer and Bibliometrix. This study provides a quantitative overview of academic trends from 2014 to 2023. The analysis reveals significant growth in scientific production, predominantly driven by the USA, China and the UK. Central themes include network security, cyberattack prevention and regulatory frameworks.

Findings

The findings emphasize that cybersecurity, artificial intelligence (AI) and regulation are critical for developing secure and reliable vehicular systems.

Research limitations/implications

Future research should focus on enhancing security in vehicle-to-everything, vehicle-to-vehicle and vehicle-to-infrastructure communications by improving protocols and integrating AI.

Practical implications

Key themes identified include trust in security, reliability and user experience.

Social implications

The analysis highlights future research directions, particularly the integration of AI with sustainable development and autonomous transportation policies.

Originality/value

This study provides a quantitative overview of academic trends from 2014 to 2023 regarding the theme of cybersecurity and self-driving cars.
Do Islamic cryptocurrency and Bitcoin co-move at different investment horizons?
Authors: Hosen Mosharrof , Mohd Thas Thaker Hassanudin , Uddin Mohammad Nazim , Qoyum Abdul , Taghizadeh-Hesary Farhad
Published: February 2025

Purpose

Cryptocurrencies, which have been popular since 2009, raise concerns among investors, researchers and professionals. Amid global economic, financial and health crises, uncertainty has surged, leading investors to seek risk reduction and portfolio diversification. While some critique conventional fiat-based cryptocurrencies, others propose asset-backed alternatives. However, the impact of Shari’ah law-based cryptocurrencies on equity market returns remains largely unexplored in existing literature. This study aims to investigate the lead/lag relationship of selected Islamic and conventional cryptocurrencies from ASEAN and global perspectives.

Design/methodology/approach

The authors collected daily data of Bitcoin, Ethereum, X8X (Islamic cryptocurrency), Cardano (Islamic cryptocurrency), S&P500, Volatility Index, Economic Policy uncertainty and FTSE Asean Index (from the 4th of November 2019 to the 1st of July 2022) to reveal empirical results through Continuous Wavelet Transform and Correlation Heatmap with Dendrogram.

Findings

The findings indicate that Bitcoin offers a diversification opportunity for FTSE ASEAN investors for the long-term horizon while S&P500 investors will benefit from short-term investment. On the other hand, Ethereum provides better investment opportunities for both indices in the short run compared to long run. Cardano and X8X offer better investment opportunities in the long run for S&P500 and FTSE ASEAN investors. Interestingly, to check the robustness, the authors used correlation Heatmap based on Dendrogram which provided almost similar results.

Originality/value

This study contributes fresh insights to the existing literature concerning cryptocurrency due to the inconclusive findings of past studies, investors are curious to know the impact of cryptocurrency on stock market return from a global perspective which is extensively overlooked, and whether there is any difference between Islamic and conventional cryptocurrency. Therefore, by investigating the abovementioned timely demand issue, this study substantially contributes to the body of cryptocurrency literature.
Evaluating the challenges of metaverse-enabled digital entrepreneurship: evidence from Saudi Arabia as an emerging economy
Authors: Alomar Jawaher Abdulrahman , Alatawi Fatmah Mohmmad
Published: February 2025

Purpose

Although several papers have been published over the past decade on various aspects of digital entrepreneurship, nothing has hitherto been written on the theme of digital entrepreneurship in the metaverse. This paper, therefore, aims to explore the key challenges of digital entrepreneurship in the metaverse, with a view to developing a model to address these challenges.

Design/methodology/approach

The Decision Making Trial and Evaluation Laboratory approach was adopted in this study to rank the selected challenges in order of importance and establish a cause-and-effect relationship between them. The data were gathered from 10 experts from Saudi Arabia who deploy augmented reality, virtual reality and other immersive technologies in the course of their business.

Findings

Three challenges, namely, “Market fragmentation (C3)”, “Technical complexity (C1)” and “Monetisation and revenue models (C5)” were highlighted in the findings as the main factors of influence in the Cause group, whereas the remaining five challenges, “Infrastructure and connectivity (C2)”, “Social and ethical considerations (C8)”, “User adoption and engagement (C6)”, “Privacy and security (C7)” and “Intellectual property protection (C4)”, were categorised in the Effect group, being significantly influenced by the challenges in the Cause group.

Originality/value

To the best of the authors’ knowledge, this is the first study to explore the challenges of metaverse-enabled digital entrepreneurship and classify the identified challenges into groups of Cause and Effect.
Motivational dimensions of slow fashion to promote environmentally and socially sustainable consumption in the fashion industry
Authors: Ortegón Cortazar Leonardo , Cachón-Rodríguez Gabriel , Pascual Nebreda Laura , Medrano Maria Luisa
Published: February 2025

Purpose

The aim of this research is to assess the impact of the motivational dimensions of slow fashion (exclusivity, equity, authenticity, functionality and localism) on environmental and socially sustainable consumption.

Design/methodology/approach

The necessary information to conduct the empirical analysis was obtained through an online survey administered to consumers of slow fashion. Data processing was carried out using the partial least squares structural equation modeling (PLS-SEM) technique.

Findings

The obtained results demonstrate that exclusivity and equity significantly influence environmentally and socially sustainable consumption. However, the results indicate that authenticity and localism only have a significant influence on socially sustainable consumption and not on environmental consumption. Furthermore, the findings also reveal that functionality has a significant impact solely on environmentally sustainable consumption.

Research limitations/implications

This study is based on self-reported data collected from buyers aged between 18 and 29, commonly known as Generation Z. Future research could enhance the generalizability of the findings by conducting comparative studies involving other age groups, both older and younger, who are interested in sustainable fashion. Although existing literature suggests that this generation shows a stronger preference for products and brands that promote environmentally and socially responsible practices, broadening the scope to include other demographics could provide a more comprehensive understanding of sustainable fashion consumption.

Practical implications

The findings suggest the importance of developing value propositions that align slow fashion with motivational factors such as exclusivity and equity. Moreover, the practical nature of these motivational dimensions is evident in maximizing their effects on environmentally friendly behaviors, care behaviors and social responsibility. It is recommended to emphasize attributes of garment scarcity, durability, degree of personalization, provenance benefits and information on the company’s social responsibility to foster environmentally and socially sustainable behaviors.

Originality/value

This research contributes to a better understanding of the motivational dimensions that influence sustainable consumption measures and provides valuable information for managers in the fashion industry by clarifying the attributes that act as triggers from the consumer’s perspective.
The implementation of Section 1071 of the Dodd-Frank Act: the legal exposure of banking
Authors: Tran Arthur M. , Winters Drew B.
Published: February 2025

Purpose

This study aims to determine whether implementation of the Consumer Financial Protection Bureau’s (CFPB) rule will achieve the goal of providing data for preliminary analysis of banks compliance with fair lending regulations.

Design/methodology/approach

Empirical analysis of the CFPB’s implementation of Dodd–Frank Section 1071.

Findings

The data available under the CFPB’s rule will suggest that banks provide less access to minority borrowers, which would be a violation of fair lending regulations. The authors show that the addition of a simple credit risk variable shows that community banks provide fair access for minority borrowers to loans.

Research limitations/implications

The analysis is limited to one year of the Fed’s Small Business Credit Survey (2017). Also, the authors are limited to the data collected by the survey.

Practical implications

Bank regulations tend to be one size fits all, which creates high compliance costs for small (community) banks with questionable benefits. The implementation of Section 1071 appears to be another example of this pattern, as the results suggest that the implementation of the CFPB’s rule for Section 1071 is unlikely to achieve its goals.

Social implications

The results have significant public policy implications for the design and implementation of banking regulations.

Originality/value

To the best of the authors’ knowledge, this study is the first research project on the topic.
Anti-money laundering law strengthened on the implementation of carbon tax in Indonesia
Authors: Lisanawati Go , Kristina Michelle
Published: February 2025

Purpose

This study aims to evaluate the efficacy of a comprehensive anti-money laundering framework in implementing the carbon tax in Indonesia.

Design/methodology/approach

This paper is a conceptual paper that uses a qualitative method. The primary sources are the regulations related to the carbon tax, followed by sets of rules for Indonesian anti-money laundering and green crime, among other things, environmental crime. Then, it continued to an analysis process until it concluded.

Findings

The money laundering scheme in the context of the carbon tax is challenging to trace and requires strengthening when integrated with other state revenue sources.

Research limitations/implications

Implementing a carbon tax is linked to money laundering risks, as it allows carbon buying and selling transactions on the carbon market. There could be a risk of state revenue leakage when implementing the carbon tax. Other than that, there are crime risks surrounding implementing the carbon tax. Therefore, other scholars can do research in the field of the compliance of the responsible parties when implementing a carbon tax.

Practical implications

Criminals are suspected of laundering money by purchasing carbon credits through brokers and reselling them, which obscures illicit sources and makes tracking difficult.

Originality/value

Indonesia should elaborate on anti-money laundering principles to ensure the secure implementation of the carbon tax in all areas and maintain financial system integrity.
East or west, home is the best: the nexus between government-public relationship, patriotism and tourism ethnocentrism in emerging tourism destinations
Authors: Rukiko Massami Denis , Amani David
Published: February 2025

Purpose

This study aims to shed light on the under-researched relationship between government–public relationship and tourism ethnocentrism via patriotism in emerging tourism destinations. The study empirically test the determinant role of government–public relationship and patriotism on tourism ethnocentrism within the theoretical lens of social exchange theory.
Cardiorespiratory Fitness Improvements Following Low‐Frequency Training Are Not Inferior to High‐Frequency Training Matched for Intensity and Volume
Authors: Tripp Thomas R. , Ghitter Rachel S. , Kontro Hilkka , Hargrave Sarah J. , Gibala Martin J. , Aboodarda S. Jalal , MacInnis Martin J.
Published: February 2025

Epidemiological evidence suggests low‐frequency physical activity provides health benefits, but the physiological impacts of weekly training frequency are understudied. We investigated whether “Weekend Warrior” (WW) training was inferior to traditional, high‐frequency (HF) training for improving maximal oxygen uptake (V̇O2max). The secondary aim was to assess integrative physiological adaptations to each protocol. Twenty‐eight sedentary‐to‐recreationally‐active adults aged 18–45 years (14 males and 14 females) were randomized to perform 8‐weeks of HF or WW training on a cycle ergometer (either four or two sessions weekly, respectively), consisting of continuous and interval exercise, with intensity and volume matched between groups. WW training was not inferior to HF training for improving V̇O2max (mean ± standard deviation; WW: 43.5 ± 6.5 vs. 47.8 ± 6.4 mL/kg/min; HF: 42.3 ± 6.2 vs. 47.3 ± 6.7; main effect of training, p < 0.001). Severe domain cycling time‐to‐task‐failure also increased in both groups (WW: 3.7 ± 1.6 vs. 8.6 ± 3.2 min; HF: 3.5 ± 0.9 vs. 7.7 ± 2.8; main effect of training: p < 0.001). Frequency did not affect improvements in hemoglobin mass (WW: 771 ± 203 vs. 790 ± 189 g; HF: 754 ± 185 vs. 765 ± 202; main effect of training: p = 0.043) or skeletal muscle oxidative capacity (WW: 0.034 ± 0.008 vs. 0.045 ± 0.015 s−1; HF: 0.036 ± 0.011 vs. 0.041 ± 0.010; main effect of training: p = 0.002), nor did it influence improvements in cardiorespiratory, substrate oxidation, voluntary muscle contractile, and perceptual responses to submaximal exercise (interaction effect: p > 0.05 for all outcomes). Eight weeks of training improved V̇O2max and a wide range of physiological outcomes with no difference between training frequencies, suggesting that the distribution of weekly exercise volume has a limited effect during short‐term training.

Trial Registration: This trial was registered at ClinicalTrials.gov identifier: NCT05908578
Management of the hypertensive patient in dentistry: narrative review
Authors: Nagni Matteo , Verdino Flavia , Potenza Sofia , Pensa Vittorio , Martinelli Andrea , D'Orto Bianca
Published: February 2025

Purpose: Considering the issues surrounding the treatment of a patient with hypertension in the dental setting, this narrative review aims to highlight what approaches and guidelines should be kept in mind when approaching a hypertensive patient.
Methods: All articles and reviews considering the topic of hypertension management in dentistry were searched on the online platform of scientific reading sites such as PubMed and Medline, selecting the most current ones, up to January 2022, including any language. Considering the keywords "hypertension," "Dentistry," "blood pressure' and "posology," randomized controlled trials (RCTs), prospective studies, observational studies, reviews, and retrospective studies were considered. Textbooks relevant to the topic were then examined, and the citations of each retrieved article and those of reviews and expert opinions were examined to include as much knowledge as possible.
Result: by analyzing the literature data, it could be inferred that hypertension should be carefully attended to and treated with appropriate precautions especially in the pre-surgical phase. 
Conclusion: controlled hypertension does not represent a contraindication to dental and surgical treatment; nevertheless, in some cases, pressure abnormalities due to severe stress attributable to the hospital environment (white coat hypertension) can be found, which if they were to lead to a pressure higher than 200 mmGH in the pre-surgical phase should lead to the cessation of clinical treatment.
Aesthetic rehabilitation in lower mandibular area for agenesis in site 4.2: a case report and literature review
Authors: Palmacci Matteo , Saverino Marco , Pancrazi Gian Luca , Ferraro Costanza , Ceresoli Lara , Manica Umberto , Nagni Matteo
Published: February 2025

Agenesis, or congenital absence of one or more dental elements, is one of the most frequently occurring craniofacial disorders in humans and is a clinical problem that compromises aesthetics and dental function from an early age. It is a condition that can involve both deciduous and permanent dentition, with contextually different prognoses and treatment solutions.
In both cases, the clinical management of this issue involves a multi-disciplinary approach designed to cover the comprehensive dental needs of patients with agenesis. Among the elements of the permanent dentition less commonly affected by this malformation are the lower lateral incisors, whose absence may be rare but, at the same time, aesthetically and functionally debilitating for the patient.
Aim: The current study presents a review of the existing literature regarding the prevalence, etiology, and classification of the various clinically detectable dental agenesis, with a focus especially directed toward absent mandibular lateral incisors and possible clinical dental management to resolve the problem. This article’s description of a case report aims to outline a possible aesthetic rehabilitation approach in the presence of these rare cases of agenesis and then present the clinical results obtained through implant-prosthetic rehabilitation combined with orthodontic therapy.
Pterygoid implants: a viable alternative for the rehabilitation of the posterior sectors of the atrophic maxilla
Authors: Rastelli Sofia , Capogreco Mario , D'Amario Maurizio , Falisi Gianni , Severino Marco , Iacomino Enzo
Published: February 2025

Osseointegrated implants are considered one of the best treatments for dental prosthetic rehabilitation. (Papaspyridakos et al., 2013, Brånemark et al., 1969).
In cases of posterior maxillary atrophy, dental rehabilitation with osseointegrated implants is challenging as there is less bone volume (pneumatisation of the maxillary sinus) and poor bone quality (type III and IV according to Misch’s classification).
In 1989, Tuslane and Tessier first described pterygoid implants, which can now be considered one of the rehabilitation solutions for patients with posterior maxillary atrophy.
The present study was conducted to evaluate the survival and success rates of pterygoid implants 3 years after placement.
The surgical activity was conducted from January 2017 to January 2019 with a sample of 37 edentulous patients (partially and/or totally) characterized by poor bone quality and quantity in the posterior maxillary area.
The results of this study supported the research hypothesis because the survival and success rates of the pterygoid implants were 99%
Clinical and histomorphometric comparison of autologous dentin graft versus a deproteinized bovine bone graft for Socket Preservation
Authors: Meme Lucia , Grilli Filippo , Pizzolante Tommaso , Capogreco Mario , Bambini Fabrizio , Sampalmieri Francesco , Mummolo Stefano
Published: February 2025

Dentin has been a significant focus of research due to its potential as a bone substitute, owing to its higher mineral content than any material derived from bone. Additionally, dentin shares two key similarities with autologous bone: it is both osteocompatible and osteoconductive, providing a physical framework for the deposition of new bone. This comparative study assessed the osteoinductive and osteoconductive capabilities of various materials commonly used in “socket preservation” or alveolar ridge preservation. The results showed that the autologous dentin matrix and bovine-derived xenografts (Bio-oss) achieved superior bone regeneration, with a greater volume of newly formed bone (measured by the BV/TV parameter) and reduced fibrous bone, which has undesirable characteristics for implant biomechanics.
Haar wavelet method for the solution of sixth-order boundary value problems
Authors: Amin Rohul
Published: February 2025

In this article, a numerical scheme is developed for solution of sixth-order boundary value problems. The Haar collocation method is developed for both linear and nonlinear boundary value problems. In this method, the sixth-order derivative in boundary value problem is approximated using Haar functions and integration is used to obtain the values of lower derivatives and approximate solution. Some examples are given for convergence of proposed method. The Haar technique devoted in this paper is compared with Septic spline method, Sine-Galerkin method, and decomposition method. Maximum absolute and root mean square errors are given for different Gauss and collocation points. Convergence rate using distinct numbers of nodal points is calculated, which is nearly equal to $2$.
Set-Based Robust Control Co-Design: Application to a Hybrid Thermal Management System
Authors: Gulewicz Demetrius , Bird Trevor , Pangborn Herschel , Jain Neera
Published: February 2025

Control co-design (CCD) techniques are effective design tools for systems with highly transient operation, such as vehicle power and thermal management systems, where electrification necessitates a shift away from steady-state cooling solutions to transient thermal management that can respond to dynamic heat generation. The primary control objective of such systems is guaranteeing robustness to uncertainty in exogenous disturbance signals. Set based methods are well suited for solving such optimization problems due to their ability to guarantee satisfaction of safety constraints. While a principal challenge with set-based methods is their computational expense, recent work has provided new ways to exactly and efficiently conduct set-based optimization for mixed logical dynamical (MLD) systems. In this work, we show how these methods can be applied to the problem of robust CCD for a hybrid thermal management system subject to a time-varying disturbance set.
Two new species of Neognathus Willmann (Acariformes: Caligonellidae) from the Aegean region of Türkiye
Authors: Akyol Mustafa
Published: February 2025

Two new species of Neognathus viz. N. irfani sp. nov., collected from litter and soil under Verbascum sp. (Scrophulariaceae), and N. aegeanus sp. nov., collected from litter and soil under Pinus brutia (Pinaceae), Alhagi pseudalhagi (Fabaceae), Olea europaea (Oleaceae) and Verbascum sp. Manisa, İzmir and Aydın provinces (the Aegean region of Türkiye), are illustrated and described. An updated key to the species of Neognathus from Türkiye is given.
A conserved lysine/arginine-rich motif is essential for the autophagic degradation of potyviral 6K1 protein and virus infection
Authors: Hu Weiyao , Deng Changhui , Qin Li , Liu Peilan , Wang Linxi , Wang Xaioqing , Shi Wei , Aziz Asma , Li Fangfang , Cheng Xiaofei , Wang Aiming , Dai Zhaoji , Xiang Xiaohua , Cui Hongguang
Published: February 2025

Potyviruses possess one positive-sense single-stranded RNA genome, mainly dependent on polyprotein processing as the expression strategy. The resulting polyproteins are proteolytically processed by three virus-encoded proteases into 11 or 12 mature proteins. One such factor, 6 kDa peptide 1 (6K1), is an understudied viral factor. Its function in viral infection remains largely mysterious. This study is to reveal part of its roles by using pepper veinal mottle virus (PVMV) as the model. Alanine substitution screening analysis revealed that 15 of 17 conserved residues across potyviral 6K1 sequences are essential for PVMV infection. However, 6K1 protein is less accumulated in virus-infected cells, although P3-6K1 and 6K1-CI junctions are efficiently processed by NIa-Pro for its release, indicating that 6K1 undergoes a self-degradation event. Mutating the cleavage site to prevent NIa-Pro processing abolishes viral infection, suggesting that the generation of 6K1 along with its degradation might be important for viral multiplication. We corroborated that cellular autophagy is engaged in 6K1’s degradation. Individual engineering of the 15 6K1 variants into PVMV allows their expression along with viral infection. Five of such variants, D30A, V32A, K34A, L36A, and L39A, significantly interfere with viral infection. The five residues are enclosed in a conserved lysine/arginine-rich motif; four of them appear crucial in engaging autophagy-mediated self-degradation. Based on these data, we envisaged a scenario which potyviral 6K1s interact with an unknown anti-viral component to be co-degraded by autophagy to promote viral infection.

IMPORTANCE

Potyvirus
is the largest genus of plant-infecting RNA viruses, which encompasses socio-economically important virus species, such as
Potato virus Y
,
Plum pox virus
, and
Soybean mosaic virus
. Like all picorna-like viruses, potyviruses express their factors mainly via polyprotein processing. Theoretically, viral factors P3 through CP, including 6K1, should share an equivalent number of molecules. The 6K1 is small in size (~6 kDa) and conserved across potyviruses but less accumulated in virus-infected cells. This study demonstrates that cellular autophagy is engaged in the degradation of 6K1 to promote viral infection. In particular, we found a conserved lysine/arginine-rich motif in 6K1s across potyviruses that is engaged in this degradation event. This finding reveals one facet of a small protein that helps understand the pro-viral role of cellular autophagy in viral infection.
Proliferation of oxygen oases in Mesoarchean oceans
Authors: Ye Hui , Wu Chang-Zhi , Wang Xiao-Lei , Yang Tao , Guan Yue , Yang Xiuqing , Hao Weiduo , Konhauser Kurt O. , Li Weiqiang
Published: February 2025

Oxygenic photosynthesis played an essential role in the accumulation of free oxygen (O2) at Earth’s surface, but questions persist regarding its evolutionary timeline. Manganese (Mn)-rich sedimentary rocks from the Mesoarchean Pongola Supergroup in South Africa have been invoked among the earliest evidence for O2-dependent Mn(II) oxidation and thus photosynthetic O2 production in oceans. However, as a singular suite of rocks, uncertainties persist about whether the evidence for O2 in the Pongola region has global implications. Here we report on another Mesoarchean Mn-rich iron formation in South China, dating back to ca. 2.88−2.80 Ga. The Dianzihe iron formation exhibits a positive correlation between Mn enrichment (MnO up to 7.08 wt%, Fe/Mn ratio down to 5.1) and negative δ56Fe values (−0.21 to −1.33‰; average = −0.91‰). This pattern requires oxygenated seawater (i.e., O2 > 10 μM) at least to the seafloor, allowing not only for the oxidation of Fe(II) and Mn(II) but also for the preservation of Fe(Mn) oxyhydroxides until post-depositional modifications. Based on our findings in China alongside the distribution of Mn-rich iron formations in South Africa, we posit that a global distribution of oxygen oases, driven by cyanobacterial O2 production, already existed in the Mesoarchean.
Systemic lupus erythematosus unmasked: intestinal pseudo-obstruction as the first presentation
Authors: Kranthi Dandi , Banerjee Debabrata , Dahale Amol , Karad Abhijeet Bhausaheb
Published: February 2025

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory condition with a varied clinical presentation. It can involve multiple organ systems and has the potential to impact any part of the gastrointestinal tract. Intestinal pseudo-obstruction (IPO) is a rare yet severe gastrointestinal manifestation of SLE. Two-thirds of SLE patients with IPO present with concomitant hydroureteronephrosis. This report details the case of a young woman who presented with IPO as the initial manifestation of SLE. The presence of proteinuria with bilateral hydroureteronephrosis in this patient with IPO prompted a trail of investigations that led to the diagnosis of SLE. This diagnosis mitigated the need for surgery, as the patient responded to immunosuppressive therapy.