bluuebunny/crossref_metadata_2025 huggingface dataset:
Mobile-Based and Self-Service Tool (iPed) to Collect, Manage, and Visualize Pedigree Data: Development Study
Authors: Sun Chen , Xu Jing , Tao Junxian , Dong Yu , Chen Haiyan , Jia Zhe , Ma Yingnan , Zhang Mingming , Wei Siyu , Tang Guoping , Lyu Hongchao , Jiang Yongshuai
Published: June 2022

Background

Pedigree data (family history) are indispensable for genetics studies and the assessment of individuals' disease susceptibility. With the popularity of genetics testing, the collection of pedigree data is becoming more common. However, it can be time-consuming, laborious, and tedious for clinicians to investigate all pedigree data for each patient. A self-service robot could inquire about patients' family history in place of professional clinicians or genetic counselors.

Objective

The aim of this study was to develop a mobile-based and self-service tool to collect and visualize pedigree data, not only for professionals but also for those who know little about genetics.

Methods

There are 4 main aspects in the iPed construction, including interface building, data processing, data storage, and data visualization. The user interface was built using HTML, JavaScript libraries, and Cascading Style Sheets (version 3; Daniel Eden). Processing of the submitted data is carried out by PHP programming language. MySQL is used to document and manage the pedigree data. PHP calls the R script to accomplish the visualization.

Results

iPed is freely available to all users through the iPed website. No software is required to be installed, no pedigree files need to be prepared, and no knowledge of genetics or programs is required. The users can easily complete their pedigree data collection and visualization on their own and through a dialogue with iPed. Meanwhile, iPed provides a database that stores all users’ information. Therefore, when the users need to construct new pedigree trees for other genetic traits or modify the pedigree trees that have already been created, unnecessary duplication of operations can be avoided.

Conclusions

iPed is a mobile-based and self-service tool that could be used by both professionals and nonprofessionals at any time and from any place. It reduces the amount of time required to collect, manage, and visualize pedigree data.
Associations of Maternal and Paternal Parenting Practices With Children’s Fruit and Vegetable Intake and Physical Activity: Preliminary Findings From an Ecological Momentary Study
Authors: Lopez Nanette Virginia , Lai Mark HC , Yang Chih-Hsiang , Dunton Genevieve Fridlund , Belcher Britni Ryan
Published: June 2022

Background

Childhood obesity prevention interventions routinely focus on changing maternal parenting practices. Failure to assess how fathers’ weight-related (ie, diet and physical activity) parenting practices contribute to children’s energy balance behaviors limits the understanding of their paternal role within the family. Examining the independent and interacting effects of fathers’ and mothers’ weight-related parenting practices on children’s diet and physical activity addresses this important research gap.

Objective

This study used ecological momentary assessment (EMA) to investigate the within-subject and between-subject independent and interactive effects of maternal and paternal encouragement to eat and preparation of fruits and vegetables (F/V) and encouragement of and taking their child to be physically active on their child’s self-reported F/V intake and physical activity engagement.

Methods

Participants included mother-father-child triads (n=22 triads, n=205-213 prompts/occasions) in the Mothers and Their Children’s Health Study and the University of Southern California Fathers Study. Simultaneously, mothers and fathers (agesmean 44.2 years, SD 5.6, and 45.2 years, SD 8.1, respectively), and their children (agemean 12.0 years, SD 0.7) completed up to 8 randomly prompted EMA surveys per day on separate smartphones for 7 days. At each prompt, mothers and fathers each reported whether they did the following in the past 2 hours: (1) encouraged their child to eat F/V, (2) prepared F/V for their child, (3) encouraged their child to be physically active, or (4) took their child to be physically active. Children self-reported whether they consumed F/V or were physically active in the past 2 hours.

Results

Results from Bayesian multilevel logistic models (all in log-odd units) indicated that at the within-subject level, greater maternal encouragement (β=2.28, 95% CI 0.08 to 5.68) of eating F/V was associated with greater child report of eating F/V, but paternal encouragement (β=1.50, 95% CI –0.83 to 4.52) showed no effects above and beyond maternal encouragement. Additionally, greater than usual paternal encouragement (β=2.28, 95% CI 0.08 to 5.54) and maternal encouragement (β=2.94, 95% CI 0.36 to 6.69) of physical activity had significant independent effects and were associated with greater child report of physical activity. No other within-subject or between-subject associations nor interactive effects were significant.

Conclusions

Findings from this study suggest that fathers play a role in supporting their children’s physical activity but not their intake of F/V. Future EMA studies should recruit larger samples to evaluate the independent and interacting roles of mothers’ and fathers’ weight-related parenting practices on child’s obesogenic behaviors.
Telehealth Technology Competency and Difficulties in the Therapeutic Process
Authors: Hynes Kevin , Tambling Rachel , Bischoff Thomas
Published: June 2022

Background

Telehealth therapy services increased during the COVID-19 pandemic and have the potential to shape service provision in the future. The growing body of research on telehealth services provides evidence of the efficacy of such services and the possibility for greater accessibility of counseling services for hard-to-reach clients. However, less is known regarding 2 unique processes of engaging in telehealth services, which are telehealth difficulties and perceived therapist telehealth competency.

Objective

This study examines the factor structure of the following 2 new measures: the Telehealth Difficulties Scale and the Therapist Telehealth Competency Scale.

Methods

Exploratory factor analyses were used with 223 participants who used telehealth services. Following this validation, these measures were tested with their association with the therapeutic alliance and therapy productiveness among clients of telehealth services using linear regressions.

Results

The study found that both measures had a one-factor structure and predicted therapeutic alliance scores. In addition, telehealth competency predicted therapy productiveness.

Conclusions

The implications for these results are discussed, and future directions are given.

Conflict of Interest

None declared.
Acceptability and feasibility of wearable transdermal alcohol sensors: A systematic review (Preprint)
Authors: Brobbin Eileen , Deluca Paolo , Hemrage Sofia , Drummond Colin
Published: June 2022

BACKGROUND

Transdermal alcohol sensors (TAS) have the potential to be used to monitor alcohol consumption objectively and continuously. These devices can provide real-time feedback to the user, researcher or health professional and measure alcohol consumption and peaks of use, addressing some of the limits of self-reported data.

OBJECTIVE

This systematic review aims to evaluate the acceptability and feasibility of the currently available devices.

METHODS

A systematic search was conducted of the CINAHL, EMBASE, Google Scholar, MEDLINE, PsycINFO, PubMed and Scopus bibliographic databases in February 2021. Two members of the study team independently screened studies for inclusion, extracted data and assessed the risk of bias. The study’s methodological quality was appraised using the Mixed Methods Appraisal Tool. The primary outcome was TAS acceptability. The second outcome was feasibility. The data is presented as a narrative synthesis.

RESULTS

We identified and analysed 22 studies. Study designs included: laboratory and ambulatory-based studies, mixed designs, randomised controlled trials and focus groups and the length the device was worn ranged from days to weeks. While views on TAS were generally positive with high compliance, some factors were indicated as potential barriers and suggestions to overcome these.

CONCLUSIONS

There is a lack of research investigating the acceptability and feasibility of TAS devices as a tool to monitor alcohol consumption in clinical and non-clinical populations. While preliminary evidence suggests their potential in short-term, laboratory-based studies with volunteers, more research is needed to establish long-term, daily use with other populations, specifically clinical and within the criminal justice system.
Digital platform for remote monitoring of patient using a smartwatch (Preprint)
Authors: Bin Kaio , De Pretto Lucas Ramos , Sanchez Fábio Beltrame , Battistella Linamara Rizzo
Published: June 2022

BACKGROUND

Vital signs monitoring such as oximetry, blood pressure and heart rate are important to follow-up the evolution of patients, alerting the need for clinical intervention and adjustments in the therapeutic process, avoiding worsening of the clinical picture, new hospitalizations and the expansion of the disabling condition. And the possibility of measuring continuously and naturally through wearable devices, such as smart watches, is a revolution in medicine through mobile health (m-health) and digital health (e-health).

OBJECTIVE

Build a digital solution that captures vital signs data from smart watches in a continuous, secure and reliable way.

METHODS

This is a single-centre prospective study following the guidelines “Evaluating digital health products” from UK Health Security Agency. A digital solution was created to capture and display data from mobile phone of the volunteers with the smartwatches. 80 volunteers were selected for this clinical trial, divided by the previous diagnosis of Covid-19 in two groups, and are followed by 24 weeks each.

RESULTS

In 14 weeks of project progress, we managed to recruit 80 volunteers, with 68 already registered in the digital solution. More than 2.8 million records have already been collected.

CONCLUSIONS

The digital solution is working properly in its role of collecting data from the smart watches of research volunteers. Vital sign values are being monitored by the research team as part of monitoring the health of volunteers. Accuracy and reliability studies still need to be performed at the end of the 24-week follow-up of volunteers.

CLINICALTRIAL

This project was submitted to the Ethics and Research Committee of the Hospital das Clínicas, Faculty of Medicine, University of São Paulo under number CAAE: 51711921.3.0000.0068 and Opinion No. 4,975,512.
Its opinion was approved on September 15, 2021 without the need for consideration by CONEP.
Correction: A Model for Estimating Biological Age From Physiological Biomarkers of Healthy Aging: Cross-sectional Study (Preprint)
Authors: Husted Karina Louise Skov , Brink-Kjær Andreas , Fogelstrøm Mathilde , Hulst Pernille , Bleibach Akita , Henneberg Kaj-Åge , Sørensen Helge Bjarup Dissing , Dela Flemming , Jacobsen Jens Christian Brings , Helge Jørn Wulff
Published: June 2022

UNSTRUCTURED

This is corrigendum for MS 35696.
Religión en los procesos de integración: una mirada a la migración mexicana en Alemania
Authors: Mora Duro Carlos Nazario
Published: June 2022

El artículo analiza qué sucede con la religión de los migrantes en los procesos de integración en las sociedades receptoras, mediante una aproximación cualitativa a la experiencia de los mexicanos y mexicanas residentes en Berlín y en matrimonio mixto con ciudadanos alemanes. La hipótesis es que las expresiones religiosas se ajustan a las dimensiones de la integración mediante una agencia adaptativa, que debe lidiar con los pesos de la valorización de las culturas y de los imaginarios sociales de los migrantes en la nación destino; por tanto, se describen algunas adaptaciones estratégicas de lo religioso durante la experiencia migratoria.
Blade Design and Performance Analysis of Wind Turbine
Authors: Vaidhye Rahul
Published: June 2022

Abstract: This paper reviews the design optimization of wind turbine blades through investigating the design methods and analyzing the performance of the blades. The current research work in this area include wind turbine blade geometric design and optimization, aerodynamics analysis, wind turbine blade structural design and dynamics analysis. Blade geometric design addresses the design parameters, including airfoils and their aerodynamic coefficients, attack angles, design tip speed ratio, design and/or rated wind speed, rotor diameter, blade aerodynamic shape with chord length and twist distributions, so that the blade achieves an optimum powerperformance. The geometry of the blade is an aerodynamic shape with nonlinear chord and twist distribution, which can be obtained based on the BEM theory with respect to given aerofoil with known aerodynamic coefficients. In terms of blade aerodynamics analysis, there are four types of aerodynamic models which can be used to predict the aerodynamic performance of blades, including blade element momentum (BEM) model, lifting panel and vortex model, actuator line model, and computational fluid dynamics (CFD) model. Among the four, computational fluid dynamics (CFD) model has been used to calculate the aerodynamic effect on the bladeairfoil. Critical Reynolds number and constant wind speed has been considered during analysis under different turbulence models Viz, spallart-almaras, k-epsilon, invicid flow. During investigation it is observed that only k- epsilon showed efficient results than others and 14 degree angle of attack (AOA) is the optimum value at which there is much lift coefficient and minimum drag
Optimized Position and Angle Tracking of Windmill System Using Arduino Joystick
Authors: T Sathish.
Published: June 2022

Abstract: In this paper, a new optimized position and angle tracking of wind mill system using smart phone app called arduino joystick, is investigated to increase the output of wind mill system by tracking direction of the wind and turn the rotor part according to the maximum wind density by arduino joystick. This System presents the development of an experimental Prototype of an emulator for wind turbines, with controllers based on android communication networks. Most of the wind mill position is in stationary or fixed direction. But the density of the air is not good enough in particular directions and it’s based on the environmental cyclic period process. So that most of the wind mills are not working continuously in all the days. The application of the android network in this system focuses on the maximum wind density direction and rotor is adjusted according to the wind density to obtain maximum power production of wind mill.
Mortality Prediction in ICU Using Artificial Neural Networks
Authors: Sricharan Cheeti
Published: June 2022

Abstract: Intensive Care Unit (ICU) death rate prediction supported artificial neural network, patients WHO have important unwellness and injury can get admitted to the unit. The dying rate for sufferers admitted to the unit can vary from Associate in Nursing underlying illness with a dying rate as low as one in twenty sufferers admitted for non-compulsory surgical operation and as excessive as one in 4 sufferers with metabolic process diseases. Artificial Neural Networks facilitate health care management selections, improve care and cut back value at same time by exploiting the applications of ANN within the care department. It helps to alter, minimize errors and predict additional correct diagnoses for the diseases or injuries that may cut back patients' risk of hospitalization supported given knowledge. Associate in Nursing empiric study was conducted with 4000+ adult patients from 100+ ICUs. The patients with ≥1 organ failure are forty sixth. Patients without infection receiving antibiotics stand for an hour. There have been 500+ deaths and 183 discharges from the unit. In 1627 patients admitted among twenty four h of the study day, the standardized mortality quantitative relation was zero.67. We have a tendency to develop our model exploitation of a synthetic Neural Network to predict the death rate of sick patients supported by their diseases, injuries, and medical records. This can additionally facilitate managing the unit beds in hospitals throughout the Associate in Nursing emergency.
Dam Gate Control System using IOT
Authors: Narasimharao Jonnadula
Published: June 2022

Abstract: Dams are in the main used for producing hydroelectricity and for irrigation purposes. This utilization has resulted within the construction of a variety of dams in potential areas over the years. As there are plenty of risk factors related to the existence of those dams, it’s became the necessity to develop a correct automatic monitoring system regarding the opening of the dam gates thereby managing a system for maintaining a secure water level in dams. Mismanagement of dams can also bring about manmade disasters. The dams that are present now are monitored and controlled manually. This ends up in pause in deciding. The proposed system involves real-time monitoring of water levels of the dam. Water levels may also range because of drastic adjustments in water levels of linked rivers of lakes, or because of the immoderate rainfall withinside the catchment area. The proposed system is an IoT system which is able to monitor and send real time parameters associated with Dam. The system also includes features like SMS alerts to the people of the locality and higher authorities, live display of water level and also the early-stage crack identification so as to scale back the risks of cracks which can lead to dam failure.
Monitoring Social Distancing Violation
Authors: Kumar Bokka Revanth , Sruthi C. , Vagdevi J Divya , Teja D Sai
Published: June 2022

Abstract: At the end of December 2019, Wuhan city in China was hit by the coronavirus illness 2019 (COVID-19). At this point, the infection has spread all over. The majority of governments have adopted a variety of steps to halt the spread of the disease. To prevent the transmission of COVID-19, people should keep a safe distance from one another. SD is one of the most effective treatments. Monitor social separation using a model that incorporates the data from YOLOv4. Starting with a video or photo, the model generates warnings for SD violations. At universities, malls, railway stations, and other public places, we deployed a deep learning system called YOLOv4 to better analyse pedestrian behaviour. A warning sub-system is activated as soon as the SD threshold (SDTH) or violation index (VI) are breached, resulting in an immediate awareness action. In addition, the current literature on SD, object recognition methods, and SD monitoring is thoroughly investigated and discussed in this work. While COVID-19 is still a threat, the model offered is designed to keep track of people in the areas where it is most prevalent.
Image Processing in Open CV
Authors: Malik Udit
Published: June 2022

Abstract: Now a day’s need of Machine Learning is growing day by day because by using Machine learning algorithm anyone can get accurate results. Image Processing is one of the many applications of machine Learning. OpenCV is one of the famously used open-source Python libraries meant exclusively for Computer Vision and Image Processing. Modules and methods available in OpenCV allow users to perform image processing with a few lines of codes
¿Qué queda hoy de Los herederos y La reproducción (1964-1971)? Preguntas, métodos, conceptos y recepción de una sociología de la educación
Authors: Passeron Jean-Claude
Published: June 2022

Este texto revisita el contexto de producción de Los herederos y La reproducción, sus influencias, sus conceptos y métodos, sus aportaciones y resultados, y su recepción y difusión. Estas obras se gestaron en un contexto de revitalización de la sociología francesa tras la Segunda Guerra Mundial, conectando con debates previos sobre la “cuestión escolar” y con la experiencia escolar y social de sus autores. Recuperando críticamente elementos de Durkheim, Weber y Marx, de otras disciplinas y de otros sociólogos contemporáneos, y combinando diversos métodos, produjeron una descripción y explicación de la relación entre origen social y éxito escolar y sirvieron de base para la renovación epistemológica propuesta por sus autores. Aunque generaron reacciones múltiples y cambiantes, debates más ideológicos que técnicos, contrasentidos y estereotipos, mostraron la importancia de la “herencia cultural” y el “capital cultural” en la desigualdad de oportunidades escolares, avivando el debate sobre la relación entre sociología y reforma social.
En torno a La reproducción, 50 años después
Authors: Subirats Marina
Published: June 2022

La reproducción sigue siendo un libro vivo. Este texto analiza, primero, los puntos centrales de la obra para ver hasta qué punto siguen hoy vigentes. En segundo lugar, examina algunas de las objeciones que surgieron más tarde y que han contribuido a que se considerara obsoleto su contenido. Los sistemas educativos siguen contribuyendo a la reproducción de las clases sociales en las sociedades actuales, condicionando la movilidad social y la constitución de las élites, aunque con algunas variaciones en los últimos cincuenta años. A pesar de la democratización del sistema escolar y el crecimiento del estudiantado universitario, ni se ha solucionado el problema del elitismo del sistema educativo que Bourdieu y Passeron denunciaron, ni se ha producido una transformación de la propia educación. El cribaje económico y cultural y nuevos mecanismos sutiles de selección hacen que los mecanismos reproductores de las desigualdades funcionen plenamente.
‘The more things change the more they stay the same’: The continuing relevance of Bourdieu and Passeron’s Reproduction in Education, Society and Culture
Authors: Reay Diane
Published: June 2022

The publication of Bourdieu and Passeron’s Reproduction had a mixed response. On the one hand the work was criticised for its determinism and pessimistic prognosis of the possibilities of educational change and, on the other hand, praised for its complex analysis of the relationship between education and class inequalities, and the workings of class domination through the educational system. This paper explores the reception Reproduction, and its companion text The Inheritors received before examining the contribution they have made, and continue to make, to understandings of social class inequalities in education. It argues that the work has continuing significance in contemporary England just as it had in 1960s France. As well as examining the relevance of Reproduction for the twenty-first century, it also focuses on the potential of Bourdieu and Passeron’s analysis for enabling animated and agentic conceptualisations of educational and social reproduction by drawing on recent case-study data from English schools. However, it also argues that the lack of sufficient questioning of the dominant educational code, as well as the absence of any moral dimensions of class culture make their study a work in progress which needed the insights of Bourdieu’s later work to bring its analysis to fruition.
OPTIMIZATION OF BEARING STRUCTURES SUBJECT TO MECHANICAL SAFETY: AN EVOLUTIONARY APPROACH AND SOFTWARE
Authors: Alekseytsev Anatoly , Al Ali Mohamad
Published: June 2022

An approach to solving the urgent problem of optimizing the load-bearing structures of buildings and structures based on adapted genetic algorithms is presented. As a tool for finding a solution, iterative schemes are used, in which, in the classical approach to evolutionary modeling, a system of constraints is used that forms the operational requirements for reinforced concrete, steel and other structures. In this case, the value of the risk of material losses is used as one of the measures of the design optimality. This value is used to assess the feasibility of increasing the initial costs of manufacturing structures, taking into account the degree of their mechanical safety in case of emergency impacts. Groups of scenarios are considered as such impacts, including local damage to one or more load-bearing elements. A limitation is formed on the resistance to progressive collapse of the structure, which is interpreted as preventing large displacements and limiting deformations of certain parts or the structure as a whole. The magnitude of the risk is determined by a relative index determined as the ratio of the likely cost for damage from material loss to the initial cost of manufacturing the structure. The block diagrams that implement such iterative processes, information about the developed software and an example of optimization of the reinforced concrete supporting structure of the frame of an administrative multi-storey building are considered.
METHOD FOR EXTRACTING DIAGNOSTIC FEATURES OF THE FACILITIES TECHNICAL CONDITION IN THE SYSTEM FOR MONITORING
Authors: Kats Vladislav , Adamtsevich Liubov
Published: June 2022

Technical diagnostics of facilities is an urgent problem during its operation. An integral part of the implementation of diagnostic monitoring systems is the development of a decision support system (DSS) based on the analysis of acoustic emission (AE) diagnostic data and machine learning methods. A necessary condition for the application of machine learning methods in the development of DSS is the process of extracting diagnostic features from the AE signal. In the present work, an improved method is proposed for extracting diagnostic features from time series of AE signals. This includes two successive steps. At the first step, the frequency and frequency-time characteristics are calculated in a sliding window of short duration, which describe local changes in the shape and structure of single pulses. At the second step, the resulting matrix of informative features is aggregated by calculating statistical moments of various orders, which makes it possible to effectively detect long-term trends in the AE signal changes emitted by the defect. Verification of the proposed method was carried out on a full-scale control object of the oil tank RVS No. 3 ("NTEK LLC"). Based on the results obtained, a conclusion was made about the effectiveness of the proposed method in the development of diagnostic monitoring systems based on acoustic emission data.
Sustainable value creation – a farm case on business model innovation
Authors: Fernqvist Fredrik , Sadovska Vera , Langendahl Per-Anders
Published: June 2022

The agricultural sector in Sweden, as elsewhere, is affected by increased intensification and specialisation, leading to fewer and larger farms. The majority of agricultural firms acquire profits by pushing an economies of scale strategy, which is not always possible for small farms. However, there are alternative strategies. This teaching case focuses on a small farm in Sweden and offers students an opportunity to study the management of business model innovation in this context. The case explores the value creation strategy of a cattle farm and applies activities such as mapping a business model, developing suggestions for business model innovation, analysing existing and lacking managerial competences and pinpointing implications for agricultural policy. As a result, profitability, competitiveness and sustainability of the study farm should be achieved, together with acquisition of knowledge and skills by its owner. This educational case is suitable for agricultural students of different levels requiring knowledge of business and management.
Bullying Among Medical Residents: Gender, Social Norms, and Reporting Behavior
Authors: Terry Danielle L. , Williamson Meredith L.C.
Published: June 2022

Introduction: Bullying behavior in residency is common, with prevalence rates ranging from 10% to 48%. Negative acts adversely impact junior physicians. The aims of this study were to examine (a) gender differences in experiences of bullying and/or negative acts while working as a medical resident, (b) residents’ perceptions of injunctive (ie, approval of) and descriptive (ie, behavior) norms related to reporting bullying behaviors, and (c) whether greater self-other differences predict greater engagement in reporting bullying behavior by others in the workplace.
Methods: Self-report surveys were administered to family medicine, internal medicine, surgical, and emergency medicine residents (N=61).
Results: Female residents reported experiencing significantly more bullying than males. Overall, resident physicians held inaccurate beliefs, and thought other residents reported bullying more often than they did. Finally, the degree of inaccuracy was associated with reporting bullying behavior.
Conclusion: These findings are an initial indication that normative interventions may be applicable with this population. In a field that struggles with high rates of burnout, finding ways to improve the culture of an organization may assist with addressing at least part of these systemic issues.
Biuret toxicity induces accumulation of nitrogen-rich compounds in rice plants
Authors: Ochiai Kumiko , Nomura Yosuke , Uesugi Asuka , Matoh Toru
Published: June 2022

Excess biuret, a common impurity in urea fertilizers, is toxic to
plants. Little is known about the mechanisms of biuret toxicity in
plants. A previous study had shown that transgenic rice ( Oryza
sativa) plants overexpressing bacterial biuret hydrolase
improved biuret tolerance. Additionally, the biuret
hydrolase-overexpressing plants showed a higher N
ratio than wild-type plants when the roots were fed
N-labeled biuret. Here, we determined biuret
accumulation in rice seedlings by directly measuring the biuret. We
found that the biuret hydrolase-overexpressing plants did not
contain biuret, whereas wild-type plants accumulated biuret in shoots in
the order of mmol L tissue water. We also found
that the concentration of allantoin, a nitrogen-rich intermediate
compound in the purine degradation pathway, in rice shoots under biuret
toxicity was higher than those in control conditions. Inhibition of
allantoinase activity by biuret was not detected, and allantoin
accumulation appeared to be associated with changes in the expression of
putative allantoin transporter genes. Furthermore, another nitrogenous
compound citrulline, which is a nonprotein amino acid, accumulated in
rice suspension cells under biuret toxicity. The accumulation of these
two nitrogen-rich compounds suggests that rice plants subjected to
biuret toxicity may need to reduce the generation of surplus ammonium
ions.
Coexistence of anti-MDA5 and anti-PL-7 in a patient with dermatomyositis: a case report
Authors: Fu Hongyan , Sun Shaofeng , Zhang Hong , Chi Shuhong , Ma Weirong , Yang Guilan , chen juan
Published: June 2022

Anti-melanoma differentiation-associated gene 5 (anti-MDA5) and
anti-threonyl-tRNA synthetase (anti-PL-7) are myositis-specific
autoantibodies, associated with rapidly progressive interstitial lung
disease (RP-ILD). A 41-year-old woman presented productive cough,
dyspnea, and muscle pain. Anti-MDA5 and anti-PL-7 were double-positive.
The patient was diagnosed with dermatomyositis-associated ILD, and
responded successfully to glucocorticoids and immunosuppressants.
Labor Market Conditions for Health and Elderly Care Workers in the People’s Republic of China
Authors: Dong Xiao-Yuan , Joffre Veronica Mendizabal , Song Yueping
Published: June 2022

This paper examines the labor market conditions of the paid workforce in the health and elderly care industry in the People’s Republic of China (PRC). Findings indicate that the wages for elderly care workers, most of whom are women, were low, and that most of the elderly care institutions had difficulty generating sufficient revenue to cover operation costs. The growth in employment in the health and elderly care industry has lagged other sectors, limiting the supply of high-quality services for the PRC’s growing population with health and care needs.
Total Postprandial Hepatic Nonesterified and Dietary Fatty Acid Uptake Is Increased and Insufficiently Curbed by Adipose Tissue Fatty Acid Trapping in Prediabetes With Overweight
Authors: Ye Run Zhou , Montastier Émilie , Noll Christophe , Frisch Frédérique , Fortin Mélanie , Bouffard Lucie , Phoenix Serge , Guérin Brigitte , Turcotte Éric E. , Carpentier André C.
Published: June 2022

Excessive lean tissue uptake of fatty acids (FAs) is important in the development of insulin resistance and may be caused by impaired dietary FA (DFA) storage and/or increased nonesterified FA (NEFA) flux from adipose tissue intracellular lipolysis. Cardiac and hepatic total postprandial FA uptake of NEFA+DFA has, however, never been reported in prediabetes with overweight. In this study, 20 individuals with impaired glucose tolerance (IGT) and 19 participants with normal glucose tolerance (NGT) and normal fasting glucose underwent postprandial studies with whole-body positron emission tomography/computed tomography (PET/CT) with oral [18F]fluoro-thia-heptadecanoic acid and dynamic PET/CT with intravenous [11C]palmitate. Hepatic (97 [range 36–215] mmol/6 h vs. 68 [23–132] mmol/6 h, P = 0.03) but not cardiac (11 [range 4–24] mmol/6 h vs. 8 [3–20] mmol/6 h, P = 0.09) uptake of most sources of postprandial FA (NEFA + DFA uptake) integrated over 6 h was higher in IGT versus NGT. DFA accounted for lower fractions of total cardiac (21% [5–47] vs. 25% [9–39], P = 0.08) and hepatic (19% [6–52] vs. 28% [14–50], P = 0.04) uptake in IGT versus NGT. Increased adipose tissue DFA trapping predicted lower hepatic DFA uptake and was associated with higher total cardiac FA uptake. Hence, enhanced adipose tissue DFA trapping in the face of increased postprandial NEFA flux is insufficient to fully curb increased postprandial lean organ FA uptake in prediabetes with overweight (ClinicalTrials.gov; NCT02808182).
Protein tyrosine phosphatase 1B deficiency improves glucose homeostasis in insulin-dependent diabetes mellitus treated with leptin
Authors: Ito Yoshihiro , Sun Runan , Yagimuma Hiroshi , Taki Keigo , Mizoguchi Akira , Kobayashi Tomoko , Sugiyama Mariko , Onoue Takeshi , Tsunekawa Taku , Takagi Hiroshi , Hagiwara Daisuke , Iwama Shintaro , Suga Hidetaka , Konishi Hiroyuki , Kiyama Hiroshi , Arima Hiroshi , Banno Ryoichi
Published: June 2022

  

Leptin, a hormone secreted by adipocytes, exhibits therapeutic potential for the treatment of insulin-dependent diabetes mellitus (IDDM). Protein tyrosine phosphatase 1B (PTP1B) is a key enzyme that negatively regulates leptin receptor signaling. Here, the role of PTP1B in the treatment of IDDM was investigated using PTP1B deficient (KO) mice and a PTP1B inhibitor. IDDM wild-type (WT) mice induced by streptozotocin showed marked hyperglycemia compared to non-IDDM WT mice. KO mice displayed significantly improved glucose metabolism equivalent to non-IDDM WT mice, whereas peripheral or central administration of leptin partially improved glucose metabolism in IDDM WT mice. Peripheral combination therapy of leptin and a PTP1B inhibitor in IDDM WT mice improved glucose metabolism to the same level as non-IDDM WT mice. Leptin was shown to act on the arcuate nucleus in the hypothalamus to suppress gluconeogenesis in liver and enhance glucose uptake in both brown adipose tissue and soleus muscle via the sympathetic nervous system. These effects were enhanced by PTP1B deficiency. Thus, treatment of IDDM with leptin, PTP1B deficiency or a PTP1B inhibitor was shown to enhance leptin activity in the hypothalamus to improve glucose metabolism. These findings suggest a potential alternative therapy for IDDM.
Psychological Distress, Pain and Insurance Claims Negatively Affect Long-Term Health-Related Quality of Life After Road Traffic Injuries
Authors: Hung Kevin K. C. , Kifley Annette , Brown Katherine , Jagnoor Jagnoor , Craig Ashley , Gabbe Belinda , Derrett Sarah , Collie Alex , Dinh Michael , Gopinath Bamini , Cameron Ian D. , FISH Investigators On behalf of the
Published: June 2022

Objective: A prospective cohort study to investigate how injury and early post-injury psychosocial factors influence health outcomes 12 months after road traffic injury.Methods: Residents of New South Wales, Australia, with road traffic injury in the period 2013–16 were recruited. Explanatory factors were evaluated for outcomes over 12 months using 12-Item Short Form Survey (SF-12) Physical and Mental Component Scores (PCS and MCS). Path models and mediation analysis were used to examine the effect of injury severity and explanatory factors.Results: SF-12 PCS and MCS outcomes were poorer among participants with baseline psychological distress, for all injury severities (β coefficients –3.3 to –9.3, p < 0.0001). Baseline pain and psychological distress, and baseline PCS and MCS were each involved in indirect effects of injury severity on 12-month PCS and MCS. Injury severity, baseline PCS and MCS, and baseline psychological distress were also associated with the likelihood of a compulsory third-party insurance claim, and claiming was negatively associated with 12-month PCS and MCS outcomes (beta coefficients –0.22 and –0.14, respectively, for both, p < 0.01).Conclusion: Baseline factors, including pain, psychological distress and lodging a compulsory third-party insurance claim, negatively impact long-term physical and mental health status following road traffic injury, emphasizing the importance of early screening and intervention.Trial registration: Australia New Zealand Clinical trial registry identification number: AC- TRN12613000889752.
LAY ABSTRACTRoad traffic injury (RTI) can lead to adverse long-term physical and mental health outcomes. This study followed participants with RTI for 12 months to assess the effects of acute post-injury psychological distress and physical and mental health outcomes. For physical health outcomes, greater severity of injury leads directly to a more restricted physical state; pain and psychological distress soon after injury also contribute to negative physical outcomes for participants experiencing more severe injuries. For mental health outcomes, injury severity has no direct effect on worsening mental state; mental state and psychological distress soon after injury leads to worsening outcomes for participants experiencing more severe injury. Individuals with higher psychological distress or pain were more likely to lodge a motor vehicle insurance claim. These people had subsequently poorer 12-month physical and mental health outcomes. It is essential to understand how early screening and interventions for psychological distress and pain can affect recovery.
Aksept og asymmetri. Status for folkemålet 160 år etter
Authors: Dimmen Torgeir Parr
Published: June 2022

In this article, I discuss the current status and position of Norwegian nynorsk, the less-used variety of the written Norwegian language. In 1885, nynorsk was formally granted equal status with Danish, the official written language in Norway at that time (later evolving into modern Norwegian bokmål). After this radical resolution in the Norwegian Parliament 137 years ago, many variables influenced the balance between the two language varieties. In the first decades after 1885, the church played an important role in the expansion and status of nynorsk. Later, other arenas had more impact, especially newspapers, literature, broadcasting and other media. All along, political regulations in public institutions and in school curriculums have constituted the framework for the development. Nynorsk writers have always been a relatively small minority, and in the last decades its use has declined further. Currently 8–10% of the population writes in nynorsk. In order to illustrate the changes in the use of nynorsk and bokmål I will present some statistics, reports and examples from different parts of society, followed by a discussion of what might influence people and institutions today in their choice of written and oral language. In recent years, the formal equality of nynorsk and bokmål has been strengthened, and there are signals of less public resistance to nynorsk. Nevertheless, nynorsk is not used by more people or in more contexts than before. The conclusion is that both the acceptance and the asymmetry are increasing.
EVOLUSI HAK PEKERJA DI ERA DIGITAL: PRAWACANA RIGHT TO DISCONNECT DI INDONESIA
Authors: Rifqi Noval Sayid Muhammad
Published: June 2022

ABSTRAK

Bagi seorang pekerja saat ini, waktu kerja tidak selalu berakhir ketika telah meninggalkan kantor. Pekerja dalam berbagai profesi kerap menerima komunikasi elektronik dari klien, kolega dan pimpinannya sepanjang waktu, termasuk pada akhir pekan maupun hari libur. Walaupun pekerja secara fisik telah meninggalkan kantor, namun tidak serta merta pekerja turut meninggalkan pekerjaannya. Pandemi Covid-19 turut kembali menguatnya keterhubungan pekerja dengan serangkaian instruksi pengusaha. Hal ini sesungguhnya telah mencederai hak dasar pekerja, bahkan merusak iklim ketenagakerjaan yang berorientasi pada keseimbangan kehidupan pribadi dan pekerjaan. Right to disconnect dapat menjadi salah satu alternatif yang dapat diadopsi sebagai solusi dini. Tiga nilai utama Right to Disconnect adalah: (1) ) hak pekerja untuk tidak melakukan pekerjaan di luar jam kerja normal; (2) hak untuk tidak menanggung akibat negatif karena melakukannya dan (3) kewajiban pihak lain untuk menghormati right to disconnect. Metode penelitian yang digunakan adalah yuridis normatif dengan pendekatan undang-undang, kasus, analitis dan perbandingan. Ditemukan kesesuaian kebijakan Right to Disconnect yang diberlakukan oleh Perancis, khususnya mengenai serikat pekerja, peraturan perusahaan serta sanksi. Kata kunci: hak digital; jam kerja; right to disconnect.

ABSTRACT

For current employees, working time does not always end when they leave their office. Employees from various professions often receive electronic communications from clients, colleagues and bosses all the time, including on weekends and holidays. Even though the employee has physically left the office, it does not mean the employee leave their job. The Covid-19 pandemic has also strengthened the relationship between employees and a series of employer instructions. This actually has violated the basic rights of employees, and even damaged the workforce climate which is oriented towards the balance of personal life and work. Right to disconnect can be an alternative that can be adopted as an early solution. The three main values of Right to Disconnect are: (1) the right of workers not to work outside normal working hours; (2) the right not to endure negative consequences for doing it and (3) the obligation of other parties to respect the right to disconnect. The research method used was juridical normative with a statute approach, case approach, analytical approach, and comparative approach. It was found that the suitability of the Right to Disconnect policy imposed by France, particularly regarding labor unions, company regulations and sanctions. Keywords: digital right; right to disconnect; work hours
IMPLEMENTASI SISTEM E-COURT DALAM PENEGAKAN HUKUM DI PENGADILAN NEGERI
Authors: Setiawan Annisa Dita , Artaji  , Sherly Ayuna Putri
Published: June 2022

ABSTRAK

Sistem terobosan yang diberi nama sistem E-Court merupakan salah satu inovasi Mahkamah Agung dalam menghadapi tantangan terkait perkembangan kehidupan manusia yang diatur dalam Peraturan Mahkamah Agung Republik Indonesia Nomor 1 Tahun 2019 tentang Administrasi Perkara dan Persidangan di Pengadilan secara Elektronik. Sistem ini dibuat untuk menjembatani kendala geografis Indonesia, membuat sistem peradilan lebih sesuai dengan asas yang ada, dan memicu peningkatan kepercayaan masyarakat terhadap penegakan hukum dan keadilan yang dilakukan oleh lembaga peradilan. Penelitian ini menggunakan metode pendekatan yuridis empiris dengan data dianalisis secara kualitatif dan spesifikasi penelitian adalah deskriptif analitis. Hasil penelitian menunjukan bahwa Implementasi Peraturan Mahkamah Agung Nomor 1 Tahun 2019 tentang Administrasi Perkara dan Persidangan secara Elektronik di beberapa Pengadilan Negeri sebagian besar sudah terlaksana dengan efektif, namun beberapa fitur seperti pemanggilan secara elektronik dan persidangan secara elektronik belum sepenuhnya diterapkan karena masih terdapat perdebatan terkait asas hukum.

Kata kunci: e-court; penegakan hukum; persidangan elektronik.

 

ABSTRACT

The E-Court system is one of the Supreme Court's innovations in facing challenges related to the development of human life, regulated in the Regulation of the Supreme Court of the Republic of Indonesia Number 1 of 2019 concerning the Administration of Cases and Trials in Courts electronically. This system was designed to solve Indonesia's geographic constraints, make the judicial system simpler and faster, reduce court costs, and increase public confidence in the judiciary in upholding law and justice. This study used an empirical juridical approach to the specifications of the research carried out in a descriptive analytical manner with data analyzed qualitatively. The results show that the implementation of Supreme Court Regulation No.1 of 2019 concerning Electronic Case and Trial Administration in District Courts has mostly been carried out effectively, but features such as electronic summons (E-Summon) and electronic trials (E-Litigation) have not fully implemented. There are still obstacles such as the trial schedule not appearing. The current E-Court regulations do not regulate access to court for the public, additional evidence, and fee refunds. Public trust in the security of the E-Court system is still low, so further socialization is needed to the public and judicial apparatus to maximize E-Court users.

Keywords: e-court; law enforcement; electronic trial.
TINJAUAN PERKAWINAN PERIPARAN BERDASARKAN PERSPEKTIF HUKUM ISLAM DAN HUKUM ADAT
Authors: Mutiara Putri Mega , Djanuardi Djanuardi , Kusmayanti Hazar
Published: June 2022

ABSTRAKPerkawinan bukanlah peristiwa kemasyarakatan biasa, melainkan peristiwa yang menimbulkan akibat-akibat yang diatur oleh hukum. Dalam masyarakat terjadi berbagai bentuk perkawinan yang sangat beragam salah satunya ialah perkawinan periparan yang banyak terjadi di salah satu daerah di Kabupaten Garut dalam dua bentuk. Pertama, pernikahan antar ipar dimana pasangan suami isteri yang menikah diikuti dengan adik mereka masing-masing melangsung peknikahan juga. Bentuk kedua, yaitu suami menikah dengan saudara pasangan. Penelitian ini bertujuan untuk mengkaji bagaimana keabsahan perkawinan periparan tersebut ditinjau berdasarkan perspektif hukum islam dan hukum adat dihubungkan dengan UUP, serta mengakaji juga bagaimanakah akibat hukum dari perkawinan periparan tersebut. Penelitian ini menggunakan metode yuridis normatif. Berdasarkan penelitian dapat diketahui bahwa perkawinan periparan dalam bentuk yang pertama sah baik menurut hukum islam dan hukum adat, sedangkan perkawinan periparan dalam bentuk kedua sah pula menurut hukum adat, tetapi menurut hukum islam sah sepanjang dilakukan tidak dalam satu waktu yang bersamaan. Kata kunci: Hukum Adat, Hukum Islam, Perkawinan Periparan.

ABSTRACT Marriage is not an ordinary social event, but an event that has consequences that are regulated by law. In society, there are various forms of marriage that are very diverse, one of which is periparan marriage, which occurs in one area in Garut Regency in two forms. First, the marriage between in-laws where a married couple is followed by their respective siblings to get married as well. The second form, namely the husband married to the spouse's brother. This study aims to examine how the legitimacy of the partner marriage is reviewed from the perspective of Islamic and customary law, and also to examine how the legal consequences of the partner marriage are. This study uses a normative juridical research method. Based on the research, it can be seen that the partner marriage in the first form is valid both according to Islamic law and customary law, while the partner marriage in the second form is also valid according to customary law, but according to Islamic law as long as it is not carried out at the same time.Keywords: Customary Law, Islamic Law, Marriage In Relation