bluuebunny/crossref_metadata_2025 huggingface dataset:
THE DIFFERENCE OF HISTOPATHOLOGICAL IMAGE OF THE WISTAR RAT’S KIDNEY ADMINISTERED WITH GRADUAL DOSAGE OF PYRETHROID
Authors: Almayang Diaz , Saebani Saebani , Dhanardhono Tuntas , Ambarwati Endang , Miranti Ika Pawitra
Published: June 2022

Background: Pyrethroid pesticide poisoning cases in developed and developing countries have a high incidence every year. One of the active substances in pyrethroid widely used is cypermethrin. The effects of cypermethrin intoxication on the kidneys, especially in humans, are little to be studied. This study aims to determine the difference in the histopathological image of the Wistar rat’s kidney.Method: The experimental research of the post-test only control group design involved 24 male Wistar rats divided into 4 groups randomly, the control (not given cypermethrin), treatments of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. Cypermethrin are given orally for 14 days. After the rats were terminated, the kidney were processed to be paraffin-embedded tissues and stained with HE. Tubular injuries were examined using 400x magnification of light microscope and focused on closure of tubular lumen as well as proteinaceous cast inside the lumens.Results: The results of this study showed that the means of histopathological damage to the kidneys increased from control group to 500 mg/kgBW treatment group. Statistical analysis with One way ANOVA showed significant differences (p<0.001), continued with Post hoc games Howell test, there was a significant differences between control group with 250 mg/kgBW treatment group and 500 mg/kgBW treatment group, and between 125 mg/kgBW treatment group with 250mg/kgBW treatment group and 500 mg/kgBW treatment group. There was no significant difference between the control group with 125 mg/kgBW group and 250 mg/kgBW treatment group with 500 mg/kgBW treatment group.Conclusion: There is a significant difference in renal histopathological  image due to exposure to pyrethroid (cypermethrin) in gradual doses. The image of kidney damages can result in tubules injury  which include: albuminous degeneration with narrowing of the tubular lumen and hyaline cast. The means of tubular injury rate will increase with increasing dose of pyrethroid.
The Effect of Various Concentrations of Liquid Smoke with Time Differences on the Viability of Candida albicans
Authors: Nahla Nahla , Lestari Endang Sri , Hardini Nadia
Published: June 2022

Background: Dentures that are rarely cleaned will trigger the growth of Candida albicans, which is a fungus known to be a major cause of opportunistic infections of the oral cavity. Liquid smoke is a chemical produced by distillation of smoke from combustion, containing phenol, carbonyl and carboxylic acids that are effective in killing fungi.Objective: To determine the effect of various concentrations of liquid smoke with different periods of time on the viability of Candida albicans.Methods: This was an experimental laboratory research with post-test only control group design. This study used Candida albicans colonies as samples with 6 different treatment concentrations of liquid smoke (100%, 50%, 25%, 12.5%, and 6.25%) and different periods of time (5 and 15 minutes), with 5 duplications.Results: The Kruskal-Wallis test on the MIC (Minimum Inhibitory Concentration) showed that there are significant differences (p <0.001) in the experimental groups, while the test on the MBC (Minimum Bactericidal Concentration) also showed the same result (p <0.001). The Mann-Whitney test stated that there was a significant difference between liquid smoke concentrations of 12.5% with positive control. The lowest concentration that could inhibit the growth of Candida albicans is 12.5%. At 24 hours incubation with 5 and 15 minute soaking time, the MBC of Candida albicans was 100% with 15 minute soaking time.Conclusions: Liquid smoke affected the growth of Candida albicans, characterized by MIC at a concentration of 12.5% and MBC at a concentration of 100% with a 15-minute soaking time.
TIME IN THERAPEUTIC RANGE (TTR) IN ATRIAL FIBRILLATION WITH WARFARIN THERAPY IN SEMARANG, INDONESIA
Authors: Sekarsari Della Dafina , Ardhianto Pipin , Kresnoadi Erwin , Sobirin Mochamad Ali
Published: June 2022

Background: Atrial fibrillation is one of the factors forming thromboembolism. The thromboembolism can be prevented with warfarin. A side effect of warfarin is increasing the occurrence of bleeding, these therapy requires an evaluation of its usage. These evaluations can be seen in the Time in Therapeutic Range (TTR) patients. TTR is the duration in which the International Normalized Ratio (INR) patients in referral value are 2.0-3.0. TTR > 70% can prevent bleeding on FA patients with warfarin therapy.Aim: To determine TTR in patients receiving warfarin with atrial fibrillation.Methods: This study was descriptive with a cross-sectional design for six months at Dr. Kariadi Hospital Semarang. TTR was calculated using Rosendaal's Methods after collecting three INRs and patients' demographics.Results: Total subject was 111 patients with an average age of 52,63 and the TTR average is 53,75. TTR in this study was divided into two groups, that groups were poor TTR (TTR < 70%) with 82 patients (73.88%) and good TTR (≥70%) with 29 patients (26.12%).Conclusions: The average TTR in FA patients with warfarin therapy was 53,75%.
Association Between Birth Weight and Quality of Life in Early and Middle Adolescence
Authors: Ni'mah Eva Latifatun , Anantyo Dimas Tri , Suswihardhyono Adhie Nur Radityo , Nugroho Teddy Wahyu
Published: June 2022

Background: Children with low birth weight tend to have a higher risk of experiencing abnormal growth and developmental delays. While the risk of developing obesity in the later years is higher in children with high birth weight. Physical and psychological conditions can affect the quality of life of adolescents.Objective: To analyze the association between birth weight and quality of life in early and middle adolescents.Methods: This cross-sectional study involved 120 students aged 13-16 years in Semarang City in which a consecutive sampling method was used.  The study was conducted in August 2020. Research subjects need to fill up the PedsQL, PAQ, birth history, and socio-economic questionnaires. Statistical analyses used were Chi-square and logistic regression tests.Results: Birth weight was significantly associated with quality of life (p=0.002). A history of abnormal birth weight increases the risk of experiencing poor quality of life as a teenager (p=0.002; OR=3.987). Low birth weight was associated with decreased physical function (p=0.001), whereas high birth weight was associated with reduced social and school functioning (p=0.013; 0.032). Gender was significantly associated with quality of life (p=0.016). Girls tend to have a higher risk of experiencing poor quality of life (p=0.021; OR=4.021).Conclusion: Birth weight has a significant association with quality of life in early and middle adolescents. Adolescents with a history of LBW or HBW were more likely to experience decreased quality of life than adolescents with a history of NBW.Keywords: Adolescence, Birth weight, Quality of Life.
EFFECT OF LEMON AROMATHERAPY ON THE ANXIETY LEVEL OF DENTAL EXTRACTION PATIENTS IN RSND SEMARANG
Authors: Laksmidevi Hayuratri Purwalalita , Utami Devi Farida , Wati Arinta Puspita , Rahmawati Maria Belladonna
Published: June 2022

Background: Dental treatment that is often done is the tooth extraction procedure. The treatment and the use of sharp instruments such as syringes, pliers, bein during extraction can cause anxiety. Anxiety will be responded by several changes in the body such as the increasing of MAP, pulse rate, and respiratory rate. Handling anxiety can be done with aromatherapy, one is lemon aromatherapy.Aim: To determine the effect of lemon aromatherapy on anxiety levels and the correlation of anxiety levels with the results of MAP, pulse rate, and respiratory rate in tooth extraction patients at RSND SemarangMethod: Experimental study with pretest and posttest control group design with sampling simple random to get 40 respondents that indicated as extraction teeth patient. Respondents were divided into 2 groups: 20 control respondents and 20 intervention respondents. Anxiety level was measured by the Modified Dental Anxiety Scale (MDAS) questionnaire. Data that was not distributed normally were the difference in pulse rate and the difference in respiratory rate, while the results of the homogeneity test obtained data that were not homogeneous were the difference between the MDAS questionnaire and the difference in the MAP. The rest of the mentioned data above were all distributed normally and homogeneous. Analysis of differences in anxiety levels between before and after lemon aromatherapy was given using paired t-test, analysis of differences in anxiety levels between the control group and the intervention group using the independent t-test, and to analyzing the correlation of anxiety levels with the results of MAP, pulse rate, and respiratory rate using the Spearman test..Results: There was a significant difference in anxiety scale between before and after lemon aromatherapy was given p = 0,000135 (p <0.05) and between the control group and the intervention group p = 0.000002 (p <0.05). There was a positive correlation between anxiety levels with the results of MAP, pulse rate, and respiratory rate.Conclusion: Anxiety of tooth extraction patients shows a decreased after inhaling lemon aromatherapy. When someone is anxiety, there will be an increase in MAP, pulse rate, and respiratory rate.Keywords: Anxiety, tooth extraction, lemon aromatherapy, MAP, pulse rate, respiratory rate.
Histopathology of Seminiferous Tubules of Wistar Rats (Rattus norvegicus) Exposed to Electric Mosquito Repellent with Active Ingredient D-Allethrin
Authors: Izzati Salwa Nabila , Armalina Desy , Ariani RR. Mahayu Dewi , Saktini Fanti
Published: June 2022

Background: An increase in mosquito-borne diseases has resulted in the use of mosquito repellents, especially electric ones in Indonesia. One of the active ingredients of electric mosquito repellent, namely d-allethrin, cangenerate free radicals resulting in oxidative stress. Oxidative stress on the testes can interfere with the spermatogenesis stage in the seminiferous tubules.Objective: Determine the histopathology of seminiferous tubules of Wistar rats exposed to electric mosquito repellents with the active ingredient d-allethrin.Methods: This study used a true experimental design with a post test only control group design. A sample of 25 Wistar rats was divided into 5 groups. The control group (K) was given only standard feed. Treatment group 1 (P1), treatment group 2 (P2), treatment group 3 (P3), and treatment group 4 (P4) were exposed to electric mosquito repellents with active ingredient d-allethrin sequentially for 8 hours/day, 12 hours/day, 18 hours/day, and 24 hours/day. After 30 days the rats were terminated. The testes were taken for histopathological observation with HE staining and assessed according to the Johnsen score criteria.Results: Based on the score, the mean value of the control group was 9.4, P1: 8.36, P2: namely 7.68, P3: 5.84, and P4: 5.64.The results of statistical tests using the one way Anova showed a significant difference (p <0.001).Conclusion: Exposure to electric mosquito repellent containing the active ingredient d-allethrin caused differences in the histopathology of seminiferous tubules score of Wistar rats.
Acute COVID-19 cardiovascular syndrome: A case report
Authors: Layanto Agus , Addin Sofyan Rais , Silitonga Friska Anggraini Helena , Nurani Ayudyah , Hellmi Rakhma Yanti , Limantoro Charles , Seno K Heri Nugroho Hario , Kholis Fathur Nur
Published: June 2022

A man 44 years old with metabolic syndrome and chronic kidney disease was presenting acute COVID-19 cardiovascular syndrome. The condition was aggravated by presence of ureterolithiasis and gout. After treatment, hemodialysis and ureteroscopic lithotripsy-double J ureteral stent, the patient was recovered from his condition
THE EFFECT OF GARLIC (Allium sativum) EXTRACT ON THE HISTOPATOLOGICAL LUNG OF BALB/C MICE WITH NICOTINE EXPOSURE
Authors: Mahardika Ardiansyah , Armalina Desy , Purnawati Ratna Damma , Istiadi Hermawan , Ismail Akhmad
Published: June 2022

Abstract Background: Nicotine is a major aspect of smoking. Nicotine cause damage to the lungs because the oxidative stress caused triggers an inflammatory response and lung damage to the alveoli. Garlic extract as an antioxidant agent so that it can against oxidative stress caused by nicotine exposure.Objective: This study is to proving the effect of multilevel dose of garlic extract on lung histopathology of BALB/c mice exposed to nicotine by inhalationMethods: The study used an experimental post test only control group design which was carried out for 24 days. Mice were given an adaptation period of 7 days followed by a treatment period of 14 days. On the last day, the lungs will be terminated and taken for histopathological tests. Mice were divided into 4 groups, namely a Healthy Control Group  that was only given standard feed, a Negative Control Group  that was given exposure to nicotine by inhalation at a dose of 10 mg/KgBW, treatment group 1 was given garlic extract 300 mg/KgBW orally and exposed to nicotine inhalation with a dose of 10 mg/KgBW, and treatment group 2 who were given garlic extract 500 mg/KgBW orally and exposed to nicotine by inhalation at a dose of 10 mg/KgBW. Histopathological preparations were made on each sample with Hematoxylin-Eosin paint which was then observed microscopically and assessed for severity of damage using scoring criteria.Results: Based on microscopic observations, the degree of lung damage is grouped into normal, mild, moderate, and severe degrees. The results in each group are in the following groups: Healthy Control Group : 73%,27%,0%,0% ; C(-) :0%,0%,33%,67% ; T1 : 0%,33%,67%,0% ; T2 : 0%,100%,0%,0%. The Kruskal Wallis test was performed to obtain significant differences, followed by the Mann Whitnney test which compared the treatment groups which showed significant results.Conclusion: By Giving garlic extract can reduce the degree of microscopic damage of mice lung due to nicotin inhalation exposure.
THE EFFECT OF THE USE OF MASK ON THE INCIDENCE OF ACNE VULGARIS IN STUDENTS OF MEDICAL FACULTY DIPONEGORO UNIVERSITY
Authors: Kurniawati Devy , Wibowo Dhega Anindita , Riyanto Puguh , Widyawati Widyawati
Published: June 2022

Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous follicles that is commonly experienced in adolescents and young adults. The pathogenesis of AV is multifactorial, such as caused by inflammation and external factors of acne exposome, which have an impact on the pathogenesis of acne in the use of masks.Objective: To determine the effect of using a mask and the number of acne vulgaris on students of the Faculty of Medicine, Diponegoro University.Methods: This research is an observational type with a cross sectional design. The research subjects were 58 students of the Faculty of Medicine, Diponegoro University with an age range of 19-23 years who used masks. The data obtained are primary data from the questionnaire. The analytical test used is bivariate chi square analysis.Results: This study showed that there was no significant effect between the type of mask and the incidence of acne vulgaris p 0.610 (p>0.05), the duration of the use of masks and the incidence of acne vulgaris p 0.200 (p>0.05), and the frequency of using masks with the incidence of acne vulgaris p 0.689. (p>0.05)Conclusion: There is no effect between the use of masks and the incidence of acne vulgaris.
ANALYSIS OF RISK FACTORS AFFECTING LUMBAL FACET JOINT OSTEOARTHRITIS IN MRI SCAN
Authors: Anastasia Aulia , Sukmaningtyas Hermina , Priambodo Agus , Setiawati Erna
Published: June 2022

Background: Osteoarthritis is a long-term, chronic disease that is usually marked by cartilage degeneration in the joints, which in turn induces bone friction. One of the subtype of this disease is facet joint osteoarthritis or in short, FJOA. In Indonesia, FJOA has not been commonly documented. The most common method for FJOA inspection is X-Ray modality. The usage of other radiology imaging, such as CT-Scan or MRI, are also used to evaluate erosion, osteophyte creation, subchondral sclerosis, and joint constriction. Nevertheless, the most ideal FJOA inspection method is still an ongoing debate due to strengths and weaknesses of each methods. CT scans are more widely used than MRIs and are typically less expensive. MRIs, however, are thought to be superior in regards to the detail of the image. Objective: To understand the effect of age, sex, and spinal level towards FJOA on MRI scanning. Method: This research used cross-sectional approach. Sample taken in this research were all radiology results from patients that fulfills inclusion criteria and had gone through MRI inspection in Jatinegara Premier Hospital. Age, sex, disk degeneration degree, and spinal level are the main focus for this study since those are the most common risk factor for FJOA. Results: 46.8% of FJOA were found in male patients while the other 53.2% were found in females. L4-5 and Grade 1 FJOA had the highest incidence found, with the amount of 29% and 48.4% respectively. There was no correlation between sex and FJOA degree based on Asymp. Sig of 0.255. There was also no correlation between age and FJOA degree based on Asymp. Sig of 0.702. However, there was a correlation between spinal level and disk degeneration degree with FJOA degree due to Asymp. Sig <0.05.  Conclusion: There was no significant relationship between age and sex to lumbar facet joint osteoarthritis and there was a significant relationship between spinal level and disk degeneration degree with lumbar facet joint osteoarthritis.
CLINICAL MANIFESTATION OF COVID-19 CO-INFECTION CASE IN BENGKULU CITY
Authors: Rizqoh Debie , Nugrahaeni Enny , Endang Jusup , Sundari Mulya , Triana Dessy , Sariyanti Mardhatillah , Massardi Nikki Aldi
Published: June 2022

Background: The COVID-19 pandemic is still ongoing, and no one could predict when it would end. In some cases of COVID-19, patients experienced infection by SARS-Cov-2 and other microorganisms, including viruses, bacteria, and fungi.Objective: This study aims to determine Co-infection on clinical symptoms and mortality of COVID-19 patients in Bengkulu City, Indonesia.Methods: We reviewed and analyzed data on patients with confirmed COVID-19 who were co-infected, including basic information, clinical manifestations, radiological and laboratory examinations, to the final status.Results: A total of 105 patients with confirmed COVID-19 participated in this study with various clinical manifestation: mild case (12%), moderate case/ mild pneumonia (52%), severe pneumonia (20%) and critical case (16%). Of the 105 patients, six patients were co-infected with human immunodeficiency virus (HIV) (1 case), Mycobacterium tuberculosis (2 cases), Salmonella thypii (2 cases), bacterial pneumonia, and viral pneumonia (1 case). As many as three of the six patients experienced inferior clinical manifestations and died.Conclusion: The co-infection of other microorganisms in COVID-19 can affect the severity and mortality in COVID-19 patients.
MAT PILATES EXERCISE IMPROVES STATIC BALACE OF YOUNG ADULTS WITH OBESITY
Authors: Ardana Yudha Hasya , Setiawati Erna , Putri Rahmi Isma Asmara , Supatmo Yuswo
Published: June 2022

Background: The prevalence of obesity in women in Semarang at the age over 18 is 29.93%. This high prevalence rate of obesity can have a negative impact on individual health. The condition of obesity is closely related to its complications that can occur in various aspects of the body's physiology, in the example it can reduce functional abilities such as static balance which can interfere with activities and decrease quality of life. One of the methods that can be used to improve static balance is mat pilates. Mat pilates prioritizes stretching and strengthening core muscles with controlled and precise movements so that mat pilates exercises can improve static balance. However, no studies have yet discussed the effect of mat pilates exercise on static balance in obese young adults Aim: To prove that  mat pilates exercise can increase static balance of  female aged 18-23 years old with obesity. Methods: This study used quasi experimental pre and post-test design and was done in August-October 2020. The subjects were 33 female students of Medical Faculty of Diponegoro University aged 18-23 years with  BMI over 27 kg/m², divided in 2 groups. Treatment group (n=15) was instructed to do 8 weeks of mat pilates exercise (3 times a week) and control group (n=18) was instructed to not do any exercise. Static balace  was measured with Flamingo Balance Test (FBT). Data’s significance was analyzed with paired t test and independent t test. Results : There’s  a significant decrease (p<0,001; paired t test) in FBT score before and after of the mat pilates treatment group from 12,31 ± 5,15 to 10,09 ± 5,59. An insignificant increase (p=0,798; paired t test) found in FBT score before and after of the control group from 12,74 ± 4,65 to 12,93 ± 6,29. The score difference of FBT test of the mat pilates treatment group and control group shows significant result (p=0,013). Conclusion: There is an improvement of static balance after mat pilates exercise intervention on female aged 18-23 years old with obesity
NURSES’ SLEEP QUALITY AND QUALITY OF LIFE DURING THE COVID-19 PANDEMIC: ANALYSIS OF CORRELATION AND DIFFERENCES IN THE RAJAWALI ISOLATION AND NON-ISOLATION WARDS
Authors: Nurhasanah Nurhasanah , Asikin Hang Gunawan , Wardani Natalia Dewi , Sarjana Widodo , Rahayu Witrie Sutaty Miliawati
Published: June 2022

Background: Nurses are one of the first-line fighters who treat Coronavirus disease 2019 (COVID-19) patients. They are prone to stress, anxiety, and sleep disturbances that can interfere with nurses providing medical services. Although some clinical research has established sleep quality and quality of life, the comparisons of sleep quality, quality of life, and each domain of quality of life for nurses who work in isolation and non-isolation wards is not well knownObjective: This study examines the correlation between sleep quality and quality of life amongst Dr. Kariadi General Hospital nurses during the COVID-19 pandemic.Methods: This quantitative study uses a cross-sectional approach. 51 nurses who worked in the Rajawali rooms in the isolation and non-isolation wards for COVID-19 at Dr. Kariadi Semarang were included by the consecutive sampling method. The instrument used are the sociodemographic questionnaire, The PSQI, and The WHOQOL-BREF Indonesian versions. Bivariate analysis was analyzed using the Spearman testResults: There was a correlation between sleep quality and the quality of life of nurses (p=0.020,r= -0.325). There was a difference between the sleep quality of nurses who work in isolation and non-isolation wards (p=0.03). There was no difference between the quality of life of nurses who work in isolation and non-isolation wards (p = 0.698).Conclusion: There is significant correlation between nurses’ sleep quality and their quality of life. There’s bad quality of life for nurses who worked inward isolation so further examination and periodic screening are needed to optimize their care.
ANTIOXIDANT EFFECT OF LONGAN PERICARP EXTRACT IN PARACETAMOL-INDUCED IN RATS
Authors: Wahyudi Nabilah Saniyya , Batubara Lusiana , Sunarsih Endang Sri , Annisaa' Eva
Published: June 2022

Background: Oxidative stress is a condition which were free radicals harm biological molecules, like lipid, protein, and DNA. Consume paracetamol can increase oxidative stress, which can cause increased level of AST and ALT serum. Longan pericarp (Dimocarpus longan L.) is one of natural ingredients that contain phenolic and flavonoids as an antioxidant to prevent oxidative stress. This study aims to prove the effect of longan pericarp (Dimocarpus longan L.) on AST and ALT serum levels of Wistar rats induced paracetamol. Methods: Experimental research with post-test only control group design. Thirty males wistar aged 2-3 months weighing 140-250 grams randomly divided into 5 groups. Group K1 was normal control group. Group K2 was induced by paracetamol 2000 mg/kgBW. Group P1, P2, P3 were induced by paracetamol 2000 mg/kgBW administered by longan shell extract (Dimocarpus longan L.) in multilevel dose 5 mg/200 gBW, 10 mg/200 gBW, and 15 mg/200 gBW. Blood samples in each group were collected to measure AST and ALT serum levels of wistar rats. Results: There were signifficant differences groups of AST serum. There were signifficant difference groups of K1-K2 (p=0,000), K2-P2 (p=0,041), and K2-P3 (p=0,010). There were signifficant differences groups of ALT serum. There were signifficant differences groups of K1-K2 (p=0,001), K2-P2 (p=0,032), and K2-P3 (p=0,006).  Conclusions:  The longan pericarp extract can lower the AST and ALT serum levels of Wistar rats induced by paracetamol.
Interpretanty lektur. Prototypowy program nauczania metodą multimedialnych modułów tematycznych (szkoła średnia)
Authors: Ślósarz Anna
Published: June 2022

Materiał nauczania warto ująć w sekwencje, aby pokazać zależności, a całość zapamiętać. Powiązane tematycznie utwory tworzą kognitywne amalgamaty. Teksty werbalne należy wiązać z multimedialnymi, aby porównywać środki wyrazowe, ucząc dekodowania i tworzenia znaczeń. Taki sposób nauczania języka ojczystego wdrożono w Australii, Finlandii, Norwegii czyli w wysoko rozwiniętych krajach. Metoda nauczania z użyciem multimedialnych modułów tematycznych polega na celowym powiązaniu treści nauczania w moduły, z których każdy zawiera teksty literackie oraz multimedia. Temat ukierunkowuje rozumienie tekstów. Prototypowy program nauczania języka polskiego w szkole średniej Interpretanty lektur zaleca głośne odczytanie tekstu wyjściowego i tematyczne powiązanie go z tekstami innych gatunków oraz multimediami. Jest wdrożony w kilku szkołach, na Uniwersytecie Pedagogicznym i Uniwersytecie Łódzkim. Stworzone na jego bazie autorskie programy należy przed realizacją skonsultować w lokalnym środowisku, w tym z uczniami.
KURUMSAL YÖNETİM ENDEKSİNDE YER ALAN ve YER ALMAYAN BANKALARIN KOVİD 19 SALGIN SÜRECİNDEKİ PERFORMANSI
Authors: BULUT Önder Mutlu , GÜRBÜZ Ali Osman
Published: June 2022

2019 yılının ikinci yarısında Çin’de ortaya çıkan ve geçtiğimiz iki yıl boyunca, bütün dünyada ve ülkemizde etkisini gösteren Koronavirüs salgını, dünyada gelmiş geçmiş en büyük felaketi ve krizi insanoğluna yaşatmaya devam etmektedir. Salgın sebebiyle ortaya çıkmış olan krizi en ez zararla atlatabilmek için yapılan çalışmalar artarak devam etmekte olup, küresel anlamda aşının yaygın hale gelmesiyle salgına çözüm oluşturulabileceği bilim insanları tarafından dile getirilmektedir. Bu çalışma ile 2020 ve 2021 yıllarında dünyada ve ülkemizde daha önce hiç karşılaşılmayan düzeyde bir ekonomik ve sosyal durgunluğun ortaya çıkmasına sebep olan salgının Türkiye üzerine etkilerinin incelenmesi hedeflenmiştir.

Çalışmada BIST kurumsal yönetim endeksi (XKURY) ve BIST Bankalar endeksinde (XBANK) yer alan toplam 11 bankanın verileri kullanılmıştır. Salgının dünyaya yayılmaya başladığı dönem “4Ç2019” olarak kabul edilmiştir. Bu sebeple çalışmaya salgın öncesindeki 5 çeyrek dönemle, salgın sürecindeki 5 çeyrek dönemin verileri analize dahil edilmiştir.

n örnek sayısının 30’dan küçük olması ve aynı örneklem grubunda yer alan bankaların, farklı çeyrek dönemlerde yapılan, aktif karlılık, kaldıraç oranı, özkaynak karlılığı, kredi/mevduat oranı ve özkaynak / toplam varlık oran ölçümlerinin ortalamalarının göz önüne alınıp karşılaştırma yapılması sebebiyle istatistiksel analizlerde bağımlı örneklemler t testi kullanılmıştır.

İncelemeler sonucunda, çalışmaya konu olan bütün finansal performans göstergeleri için, salgın öncesi ve salgın sürecindeki dönemlerin arasında anlamlı farkların meydana geldiği istatistiksel olarak görülmüştür.
KURALA DAYALI-İHTİYARİ POLİTİKA TARTIŞMALARI ÇERÇEVESİNDE TAYLOR KURALI: TCMB ÖZELİNDE BİR UYGULAMA
Authors: EROĞLU İlhan , ŞEKER Hilal
Published: June 2022

Bu çalışmada kurala dayalı ve ihtiyari para politikası tartışmalarından hareketle 2006-2021 dönemi baz alınarak, Türkiye’de Taylor Kuralı dahilinde para politikasının enflasyon açığı, üretim açığı ve kur açığı değişkenleri ile ilişkisi belirlenmeye çalışılmıştır. Söz konusu değişkenlerden sapmalar yaşandığında kısa vadeli faiz oranlarının nasıl seyir izlediği ARDL Sınır testi modeli ile incelenmiştir. İki modele dayanan analizin ilk modelinde Geleneksel Taylor Kuralı, ikinci modelinde ise döviz kurunun da dahil edildiği Genişletilmiş Taylor Kuralı incelenmiş; ilk model için faiz oranları ile üretim açığı arasında anlamı bir ilişki saptanmazken, enflasyon açığı ile faiz oraları arasında negatif bir ilişki bulgulanmıştır. Bu bulgu TCMB’nin politika faizinde fiyat istikrarını göz etmediği şeklindedir. Döviz kurunun da analize dahil edildiği ikinci modelde ise politika faizi ile üretim açığı arasında pozitif ve istatistiki açıdan anlamlı bir ilişki; politika faizi kur açığı arasında negatif ve istatistiki açıdan anlamlı bir ilişki bulgulanmıştır. TCMB’nin politika faizini belirlerken, üretim ve kur değişkenlerini dikkate aldığı sonucuna ulaşılmıştır.
ORMANLARDAKİ İŞ KAZALARINDA ORMAN İDARESİNİN HUKUKİ SORUMLULUĞU
Authors: GÜLOĞLU Yavuz , CESUR İlknur , BULUT Alper
Published: June 2022

Bireyin çalışma hürriyetini kullanabilmesi, bu hakka yönelik tehditlerin bertaraf edilmesi, hakkın ihlali durumunda oluşabilecek olumsuzluklara karşın önlem alınması devletin görev ve sorumlulukları arasındadır. İşçi ve işveren arasında iş sözleşmesine dayalı olarak kurulan iş ilişkisinde, işverene yüklenen işçiyi gözetme borcu, yasadan kaynaklanan bir sorumluluktur. İşçi ve işveren arasındaki karşılıklı borç ve sorumlulukların düzenlendiği iş ilişkisinde işçinin işyeri sınırları içerisinde, işverenin emir ve talimatı altında bulunduğu süre zarfında, aniden ve beklenmedik bir şekilde maruz kaldığı kaza, iş kazası olarak kabul edilmektedir.

Ağır ve tehlikeli iş kolu sınıfında yer alan orman işleri, olası iş kazalarına açık bir iş koludur. Ormanlarda, orman işçileri tarafından yapılacak işlere ilişkin birtakım yasal düzenlemeler bulunmaktadır. Orman idaresi tarafından ormanlarda yaptırılan kesme, sürütme, istifleme, taşıma işleri çoğunlukla vahid-i fiyat sözleşmesi usulüyle yapılırken son zamanlarda dikiliden satış usulünde de artış kaydedilmektedir. Bu çalışmada orman işçileri tarafından vahid-i fiyat sözleşmesi ve dikiliden satış usulüne göre ormanlarda yaptırılan işler esnasında, işçilerin uğradığı iş kazalarında orman idaresinin sorumluluğu belirlenmesi amaçlanmaktadır.
Potentials of autophagy enhancing natural products in the treatment of Parkinson disease
Authors: Olubodun-Obadun Taiwo G. , Ishola Ismail O. , Adeyemi Olufunmilayo O.
Published: June 2022

Parkinson disease (PD) is a progressive neurodegenerative movement disorder characterized by motor and non-motor symptoms due to loss of striatal dopaminergic neurons and disruption of degradation signaling leading to the formation of Lewy bodies (aggregation of α-synuclein). Presently, there are no disease modifying therapy for PD despite improvement in the understanding of the disease pathogenesis. However, the drugs currently used in PD management provide symptomatic relieve for motor symptoms without significant improvement in non-motor complications, thus, a public health burden on caregivers and healthcare systems. There is therefore the need to discover disease modifying therapy with strong potential to halt the disease progression. Recent trend has shown that the dysfunction of lysosomal-autophagy pathway is highly implicated in PD pathology, hence, making autophagy a key player owing to its involvement in degradation and clearance of misfolded α-synuclein (a major hallmark in PD pathology). In this review, we described the current drugs/strategy in the management of PD including targeting the autophagy pathway as a novel approach that could serve as potential intervention for PD management. The discovery of small molecules or natural products capable of enhancing autophagy mechanism could be a promising strategy for PD treatment.
Using the Health and Retirement Study for Research on the Impact of the Working Conditions on the Individual Life Course
Authors: Mullen Kathleen J.
Published: June 2022

The aim of this paper is to evaluate the utility of the Health and Retirement Study (HRS) for studying the impact of working conditions on individuals’ health, well-being and labor supply decisions at older ages. I provide a brief overview of the information on working conditions that is currently available in the HRS and discuss implications for studies on the effects of working conditions on the individual life course. I conclude with a discussion of how recent and projected trends in the U.S. workforce are reflected in the current HRS survey content.
A 3D empirical model of standard compaction curve for Thailand shales: Porosity in function of burial depth and geological time
Authors: Puttiwongrak Avirut , Nufus Syukratun , Chaiyasart Chaiyaphruk , Giao Pham Huy , Vann Sakanann , Suteerasak Thongchai , Hashimoto Kiyota
Published: June 2022

Shale rock formed from small clay particles, and shale compaction is an essential factor to estimate shale reserves. The classical Athy’s model has been used to obtain the shale compaction curve to describe the relationship between porosity and depth, an essential input data for basin modelling. But recent studies revealed that burial time, among other factors, should be considered and that geological age is another important factor in some regions. This is because geological and lithological histories are crucially different among geological ages. This study employed the newest data of Thailand shales and confirmed that different geological ages (Cenozoic, Mesozoic, and Paleozoic ages) require different shale compaction curves by estimating numerical geological time with the relationship of velocity and depth in each geological age. We obtained empirical models of the shale compaction curve of each geological age by multi-linear regression. The standard curve of shale compaction with the relationship among porosity, depth, and time, proposed in a previous study, was also re-affirmed with the newly obtained models.
Chinese Cultural Spirit: The Expression of Values in Chinese Films
Authors: Wang Haizhou , Yuan Yaxuan
Published: June 2022

One of the particular characteristics of Chinese films is that they are based on the unique sources of Chinese cultural thought. This article examines the main spiritual ideas of traditional Chinese culture through the lens of the three relationships between heaven and man, humans and other humans, and man and himself. It explores how Chinese films made in different cultural contexts and historical backgrounds have expressed the spirit of Chinese culture through both inheritance and transformation. We approach this issue by focusing on expressions of the traditional concepts of “the unity of man and heaven,” “vigor and promise,” “balanced harmony and the golden mean,” and “the unity of body and mind.”
Some results on certain types of Putcha semigroups
Authors: Gigoń Roman S.
Published: June 2022

We shall prove a variety of results on certain types of Putcha semigroups such as: left weakly commutative semigroups, 𝓡-commutative semigroups, 𝓡𝓒-commutative semigroups, generalized conditionally commutative semigroups.
Highly active selenium nanotherapeutics combined with metformin to achieve synergistic sensitizing effect on NK cells for osteosarcoma therapy
Authors: Du Yanxin , Zhang Zehang , Yang Yu , Liu Ting , Chen Tianfeng , Li Xiaoling
Published: June 2022

NK cells-based cancer therapy combined with chemotherapeutic drugs for the treatment of tumors can enhance the immunosensitivity of NK cells, increase the expression of NK cell receptors, and eventually boost the killing effect of NK cells on cancer cells. Selenium (Se) with different chemical structures can be metabolized into selenoproteins to regulate tumor and immune cells’ fate and functions. Herein, we found that, functionalized Se nanoparticles (SeNPs) combining with metformin (met) could amply the immunotherapeutic effects of NK92 cells against osteosarcoma cancer. The results revealed that TW80-SeNPs combined with met had the optimum performance on NK92 cells for HepG2 cells, owing to the increased ROS in HepG2 cells and the augmented expression of cell surface receptor proteins ULBP-3/4, PD-L1, MICA, and NK92 cell surface receptor proteins PD-1 and FasL. Additionally, TW80-SeNPs were gradually metabolized into selenoproteins (Gpx4 and TR1) into human osteosarcoma MG63 cells to reinforce the anticancer effect of NK92 cells by regulating the redox balance in the tumor microenvironment. This study provides a therapeutic approach in treating cancer itself or diabetes coupled with cancer. Moreover, it provides a multidrug strategy to improve immune cell function in practical applications, especially for synergistic immunotherapy of osteosarcoma.
Modeling a continuous digester extraction screen zone with an approximated flow model
Authors: Gilbert Wesley , Allison Bruce
Published: June 2022

Phenomenological continuous digester models are normally limited to axial flow. However, under industrial conditions, liquor also flows radially in extraction zones. While multidimensional expansion using computation fluid dynamics is possible, the increase in mathematically complexity and computation burden is intractable for online control and optimization. In this work, an approximate algebraic flow model is proposed which removes the need to evaluate momentum continuity. The model, based on streamlines, superimposes radial and axial flow profiles. The dynamic response, when compared against a single continuous stirred tank model, was found to better predict the process response during industrial trials. Simulation studies suggest enhanced lignin removal and variability reductions are possible by increasing recirculated liquor flow rates in the zone, a result of flattening the radial chemical and temperature profiles in the chip phase. However, a minimum occurs as chemical and energy losses in the extracted flow leaving the zone take precedence.
Ultrasonic viscosity-reduction vacuum residue oil
Authors: Pan Yi , Lou Xu , Yang Shuangchun , Cui Xianglong , Stephan Zabiti Mubuto
Published: June 2022

With the rapid development of economy, the demand for energy is increasing rapidly. And the output and processing amount of vacuum residue oil are also increasing year by year. The processing of vacuum residue oil is always a difficult problem in petrochemical industry. The high viscosity is the significant characteristic of vacuum residue oil. It is easy to cause serious influence in residue oil processing, such as reactor blockage. With the development of ultrasonic technology, ultrasonic viscosity reduction has become the focus of research. Its potential role in petrochemical industry has attracted more and more attention. Ultrasonic viscosity reducing vacuum residue oil is a new viscosity reducing process. Compared with the traditional viscosity reduction method, it has good viscosity reduction effect. The research progress of ultrasonic viscosity reducing vacuum residue oil is reviewed. In this paper, the mechanism of ultrasonic action, physical and chemical effects, ultrasonic viscosity reduction treatment conditions, viscosity reduction residue oil system influence and viscosity recovery, ultrasonic sound field simulation are reviewed and analyzed. In addition, ultrasound has a synergistic effect. Ultrasonic synergistic physicochemical methods (microwave; hydrogen donor) also has remarkable effects. Ultrasonic treatment technology is adopted on the basis of traditional microwave viscosity reduction and residue oil hydrogenation donor. This kind of ultrasonic collaborative method has excellent application prospect. But there are problems with this technology. The research direction of ultrasonic viscosity reduction residue oil in the future is also suggested. It can provide reference for related research.
Advances in facet-dependent photocatalytic properties of BiOCl catalyst for environmental remediation
Authors: Hao Linjing , Zhang Tingting , Sang Haoran , Jiang Suyu , Zhang Jie , Yang Jinghe
Published: June 2022

Bismuth chloride oxide (BiOCl) is a typical V-VI-VII ternary oxide material, which is one of the widely studied metal oxides due to its unique surface, electronic and photocatalytic properties. However, the broad bandgap and the large number of photogenerated electron-hole pair complexes of BiOCl limit its photocatalytic efficiency. Since the photocatalytic performance of BiOCl is highly dependent on its exposed crystallographic facets, research attention has increasingly focused on the different structures and properties possessed by different crystallographic facets of BiOCl. This article reviews the basic principles of using different crystalline surfaces of BiOCl materials to enhance photocatalytic activity, summarizes the applications of BiOCl single-crystal catalysts and composite catalysts in the environmental field, and provides an outlook on the challenges and new research directions for future development in this emerging frontier area. It is hoped that the crystalline surface-related photocatalysis of BiOCl can be used to provide new guidance for the rational design of novel catalysts for various energy and environment-related applications.
Damage Classification Methodology Utilizing Lamb Waves and Artificial Neural Networks
Authors: Ramalho Gabriel M. F. , Barbosa Manuel R. S. P. , Lopes António M. , da Silva Lucas F. M.
Published: June 2022

As the aerospace industry develops, there is a need for applying new materials and construction techniques, able to create lighter and more efficient aircrafts. Most advances also imply severe regulations that require novel methods suited to monitor critical components. One method that goes beyond simple nondestructive testing is structural health monitoring (SHM), more specifically Lamb waves (LW)-based SHM. Indeed, LW have shown great promise in nondestructive in-situ testing, but require computationally expensive calculations, so that precise results can be obtained. An opportunity to overcome LW drawbacks arises with the use of machine learning (ML) algorithms. In this article, the performance of conventional feedforward and convolutional artificial neural networks for damage classification in aluminum sheets is compared, and a novel methodology to classify damage is proposed. The ML techniques adopted require large sets of prior data, which are generated by numerical simulations utilizing the finite element method. The damage classification pipeline comprises (i) generating LW by one actuator, measuring the structure response using a set of sensors, (iii) extracting features from the raw signals and training the ML algorithms, and (iv) assessing the classification accuracy. The methodology has the advantage of being baseline free, easily extendable for automatic feature extraction and testing, and adaptable to different types of damage and structures, as long as the algorithms are trained with suitable data.
Performance Evaluation of High Modulus Asphalt Concrete (HMAC) Prepared Using Asphaltenes-Modified Binders
Authors: Kamran Farshad , Ghasemirad Amirhossein , Baghaee Moghaddam Taher , Bayat Alireza , Hashemian Leila
Published: June 2022

High strength, extended fatigue life, and improvement in rutting resistance are the main advantages of using high modulus asphalt concrete as a base course material in the pavement structure. The primary goal of this paper was to investigate the performance properties of the high modulus base course using different asphaltenes-modified binders. A crude oil binder and two different asphalt binders from Alberta oil sands sources were used to prepare the mixtures. To prepare hard-grade asphalt binders, all binders were modified using asphaltenes, a waste byproduct of the deasphalting of Alberta oil sands. The performance grades of the modified and unmodified binders were determined, and a mix design was developed for the high modulus asphalt concrete mixes. To evaluate the performance properties of high modulus asphalt concrete mixes composed of unmodified and asphaltenes-modified binders, Hamburg wheel tracking, dynamic modulus and flow number, and indirect tensile strength at low temperature were conducted. The high-temperature performance test results, including Hamburg wheel tracking and flow number tests, indicated that asphaltenes-modified mixtures show higher resistance to permanent deformation. However, the indirect tensile strength test results at low temperature showed higher tensile strength and lower fracture energy for the asphaltenes-modified mixtures compared with the unmodified samples. Moreover, according to the dynamic modulus test results, the asphaltenes-modified mixtures exhibited higher modulus values (stiffness) than the unmodified samples at different loading frequencies compared with the unmodified samples.
Implementation of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) and Law No. 5 of 1990 in Law Enforcement Efforts and Guarantees of Environmental Rights in Gunung Leuser National Park, Indonesia
Authors: Lubis Muhammad Ikhsan
Published: June 2022

Indonesia is renowned for its abundant natural resources and vast biodiversity. However, Indonesia also has wildlife species that are most vulnerable to the threat of extinction. Illegal wildlife trade poses a serious threat to the preservation of wildlife in Indonesia. Wildlife illegally traded based on facts found in the field is mostly a catch from nature, not from captive breeding. Gunung Leuser National Park (Taman Nasional Gunung Leuser, TNGL) as one of the national parks in Indonesia faces problems in the protection of this wildlife. This is triggered by the process of industrialization, illegal logging activities and crimes against protected wildlife. Wildlife protection in Indonesia and internationally is regulated legally through Law No.5 of 1990 and internationally through the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). The role of local government, BKSDA TNGL, and related agencies in suppressing the extinction rate provides an understanding to the community of TNGL conservation areas, in particular, to reduce conflicts and clearance of plantation land by utilizing the concept of environmentally sustainable development as well as providing the mitigation measures.