bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the $$\mathrm {X_{AV}}$$ state through its electromagnetic properties
Authors: Özdem Ulaş
Published: April 2024

To improve our understanding of the quark–gluon dynamics underlying multiquark states, we systematically study their electromagnetic properties. In this study, the magnetic and quadrupole moments of the theoretically predicted singly-charmed state with the quantum numbers $$\textrm{J}^\textrm{P} = 1^{+}$$

J
P

=

1
+

is investigated within the framework of the QCD light-cone sum rules method by considering the diquark–antidiquark configuration of this state with quark contents $$[ud][\bar{c}\bar{s}]$$

[
u
d
]
[

c

¯

s

¯

]

. The predicted results for the magnetic and quadrupole moments are as $$\mu _{\mathrm {X_{AV}}}=-0.89 ^{+0.14}_{-0.12}~\mu _N $$

μ

X
AV

=
-
0
.

89

-
0.12

+
0.14

μ
N

and $$\mathcal {D}_{\mathrm {X_{AV}}} = (-0.46 ^{+0.07}_{-0.06})\times 10^{-2} ~\text{ fm}^2$$

D

X
AV

=

(
-
0
.

46

-
0.06

+
0.07

)

×

10

-
2

fm
2

. The results obtained can be useful in determining the exact nature of this state. This work will hopefully stimulate experimental interest in the study of the electromagnetic properties of multiquark systems.
Electronic and optical properties of tetrapod quantum dots under applied electric and magnetic fields
Authors: Hahn R. V. H. , Mora-Rey F. , Restrepo R. L. , Morales A. L. , Montoya-Sánchez J. , Eramo G. , Barseghyan M. G. , Ed-Dahmouny A. , Vinasco J. A. , Duque D. A. , Duque C. A.
Published: April 2024

In this work, the ground and low-lying excited states in GaAs tetrapod-shaped nanocrystals and in CdTe/CdS core/shell tetrapod-shaped nanocrystals are computed in the case of a finite confinement potential model using the finite element method and the effective mass approximation. For the single material tetrapod, electron energy levels are studied as a function of size parameters and the intensity of externally applied electric and magnetic fields, while for the core/shell tetrapod the electron and hole states are analyzed relative to size parameters of the core and shell thickness. The results show that the energies are strongly influenced by the tip-arm geometry, arm diameter, shell thickness and the intensity of the electric and magnetic fields.
Update of high voltage isolation control and monitoring system for HVE-400 ion implanter
Authors: Li Chengbo , Sun Xuepeng , Liu Zhiguo , Guo Chungang , Li Xiaoming
Published: April 2024

HVE-400 ion implanter is special ion implantation equipment for semiconductor materials boron and phosphorus doping. The ion source and extraction deflection system are at high voltage platform, while the corresponding control system is at ground voltage position. The control signals and measurement signals of various parameters at the high-voltage end need to be transmitted between ground voltage and high voltage through optical fibers to isolate high voltage. Upgrading is carried out due to the aging of the optical fiber transmission control and monitoring system, which cannot work stably. The transformation replaces the original distributed single-point control method with an advanced distributed centralized control method, and integrates all control and monitoring functions into an industrial control computer for digital operation and display. In the computer software, two kinds of automatic calculation of ion mass number are designed. After upgrading, the implanter high-voltage platform control and monitoring system features digitalization, centralized control, high reliability, strong anti-interference, fast communication speed, and easy operation.
Computation of the knot symmetric quandle and its application to the plat index of surface-links
Authors: Yasuda Jumpei
Published: April 2024

A surface-link is a closed surface embedded in the 4-space, possibly disconnected or non-orientable. Every surface-link can be presented by the plat closure of a braided surface, which we call a plat form presentation. The knot symmetric quandle of a surface-link [Formula: see text] is a pair of a quandle and a good involution determined from [Formula: see text]. In this paper, we compute the knot symmetric quandle for surface-links using a plat form presentation. As an application, we show that for any integers [Formula: see text] and [Formula: see text], there exist infinitely many distinct surface-knots of genus [Formula: see text] whose plat indices are [Formula: see text].
AN ENHANCEMENT IN THE COPPER ELECTRODE WEAR CHARACTERISTIC ELECTRICAL DISCHARGE MACHINED INCONEL 718 THROUGH ION NITRIDING, LASER SURFACE HARDENING AND HYBRID PROCESS
Authors: DHANABALAN S. , RAJ KUMAR D. , JEYAPRAKASH N. , SATHEESH KUMAR M. , VASUDEV HITESH
Published: April 2024

The virgin copper electrode has limited application due to its wear and mechanical properties using Electrical Discharge Machined (EDMed) on Inconel 718 superalloys. In order to enhance the performance of copper electrodes, in this work, Ion Nitriding (IN), Surface Hardening by Laser (LSH) and Hybrid Process ([Formula: see text]) are performed on copper electrodes to reduce the electrode wear in frontal and lateral. The electrode wear in the frontal and lateral of virgin copper electrode is processed and studied using EDM with varying pulse durations, current and Silicon Carbide (SiC) mixed EDM oil. The surface hardness in virgin and processed electrodes is also investigated. Overall analysis found that the hybrid technique produced a 59% higher hardness than that of virgin copper. The hardness in the EDMed surface was higher than that of the processed copper surface. A 1000[Formula: see text][Formula: see text]s pulse duration, 2 A current and 15 g/l SiC powder mixing EDM oil produced a low frontal wear in both virgin and processed copper electrodes. The electrode wear was reduced by 30% for frontal and 76% for lateral using a hybrid method.
Kirchhoff’s Law of Thermal Radiation Has Not Been Violated
Authors: Kirk Alexander P.
Published: April 2024

Although violation of Kirchhoff’s Law of Thermal Radiation has been claimed in a magneto-optic structure, it is shown that Kirchhoff’s Law of Thermal Radiation has not been violated, noting that violation of Kirchhoff’s Law of Thermal Radiation would imply that the Second Law of Thermodynamics has also been violated.
Fourth Party Logistics Routing Problem Under Uncertain Time and Random Demand
Authors: Gao Xinyu , Gao Xin , Liu Yang
Published: April 2024

With the rapid development of the economy, the fourth party logistics (4PL) has become an indispensable part of economic development, and the path optimization is an important topic in the research of 4PL routing problem. This paper studies the fourth party logistics routing problem with random demand and uncertain transportation time and transfer time by considering the randomness and uncertainty of the environment. In order to solve the path optimization strategy that minimizes the total transportation cost, this paper establishes an uncertain random programming model under the constraints of the total transportation time, the carrying capacity of the logistics provider, the transfer capacity of the transfer station, and the demand of the distributor. Subsequently, this paper transforms the uncertain random programming model into an equivalent deterministic programming model based on the distribution functions of random demand and uncertain time, and verifies the effectiveness of the model through two examples. The results show that the uncertain random programming model can give a reasonable path optimization strategy.
On improper interval colorings of complete multipartite graphs
Authors: Mkrtchyan Rafayel
Published: April 2024

An improper edge-coloring of a graph [Formula: see text] is a mapping [Formula: see text]. An improper edge-coloring of [Formula: see text] is called an improper interval coloring if the colors (excluding repetitions) of the edges incident to each vertex of [Formula: see text] form an integral interval. An improper coloring of [Formula: see text] is called [Formula: see text]-improper coloring, if there are at most [Formula: see text] adjacent edges with the same color. In this note we show that complete multipartite graphs have a [Formula: see text]-improper interval coloring; this proves a conjecture of Casselgren and Petrosyan.
Monotonicity of the logarithmic energy for random matrices
Authors: Chafaï Djalil , Dadoun Benjamin , Youssef Pierre
Published: April 2024

It is well known that the semi-circle law, which is the limiting distribution in the Wigner theorem, is the minimizer of the logarithmic energy penalized by the second moment. A very similar fact holds for the Girko and Marchenko–Pastur theorems. In this work, we shed the light on an intriguing phenomenon suggesting that this functional is monotonic along the mean empirical spectral distribution in terms of the matrix dimension. This is reminiscent of the monotonicity of the Boltzmann entropy along the Boltzmann equation, the monotonicity of the free energy along ergodic Markov processes, and the Shannon monotonicity of entropy or free entropy along the classical or free central limit theorem. While we only verify this monotonicity phenomenon for the Gaussian unitary ensemble, the complex Ginibre ensemble, and the square Laguerre unitary ensemble, numerical simulations suggest that it is actually more universal. We obtain along the way explicit formulas of the logarithmic energy of the models which can be of independent interest.
Thrust-related metamorphism in Carboniferous slates of southern Patagonia (South America): the fate of forearc successions
Authors: Suárez Rodrigo Javier , González Pablo Diego , Oriolo Sebastián , Parada Martín Nazareno , Ramos Miguel Esteban , Ghiglione Matías C. , Zaffarana Claudia , Albano Juan , Ponce Juan José
Published: April 2024

The Devonian to early Carboniferous western margin of Patagonia (South America) includes a NW–SE-trending magmatic arc associated with a NE-dipping palaeo-subduction zone. Along the Andean region of southern Patagonia, the Eastern Andean Metamorphic Complex developed in a forearc position and consists of a succession of very low- to low-grade metaturbidite–metabasic rocks emplaced from the Devonian to Carboniferous. There are significant uncertainties surrounding this metamorphic complex, mainly related to the tectonosedimentary setting of the basin and the subsequent conditions of deformation and metamorphism, which hinder our understanding of the orogenic architecture. To reveal the links between tectonics and metamorphism, we conducted a structural analysis and sampled metapelites to measure the illite crystallinity along a regional structural cross-section in the Eastern Andean Metamorphic Complex. Our analysis reveals broadly lower to upper anchizonal metamorphism roughly synchronous with deformation along northwards-verging thrusts. These findings support the development of a forearc hyperextended basin that was subsequently closed during the Gondwanide Orogeny (late Paleozoic), a model that reconciles previous proposals suggesting passive margin v. back-arc basin models. This closure led to the emplacement of supra-subduction zone ophiolites and turbidites over the continent through the landwards migration of brittle–ductile reverse shear zones.

Supplementary material:
Measurements of the Kübler index are available at
https://doi.org/10.6084/m9.figshare.c.7160849

Thematic collection:
This article is part of the Ophiolites, melanges and blueschists collection available at:
https://www.lyellcollection.org/topic/collections/ophiolites-melanges-and-blueschists
Doing and Defining Interdisciplinarity in Undergraduate Computing
Authors: Newhouse Kaitlin N. S. , Lehman Kathleen J. , Wofford Annie M. , Sendowski Michelle
Published: April 2024

Interdisciplinarity has been touted as a means to recruit more racially and gender-diverse students to computing. In this explanatory sequential mixed-methods study, we investigated demographic characteristics among a sample of undergraduate students pursuing interdisciplinary computing major and minor combinations at 15 institutions in the United States who completed a survey at the end of their introductory course. Descriptive analyses of responses to this survey of introductory computing students revealed that enrollment in interdisciplinary major and minor combinations was limited and did not appear to disproportionately attract women or Black/African American, Latine, Indigenous, and/or Multiracial students. We then conducted a directed content analysis of departmental websites to examine the language and policies that may have precluded or encouraged students to pursue interdisciplinary computing major and minor combinations. Findings revealed that departmental offerings of such programs were limited, and, among those that did offer such programs, communication about their goals and requirements was often lacking. Implications for research and practice, especially as they pertain to efforts to broaden participation in computing, are discussed.
MIMIC: Misogyny Identification in Multimodal Internet Content in Hindi-English Code-Mixed Language
Authors: Singh Aakash , Sharma Deepawali , Singh Vivek Kumar
Published: April 2024

Over the years, social media has emerged as one of the most popular platforms where people express their views and share thoughts about various aspects. The social media content now includes a variety of components such as text, images, videos etc. One type of interest is memes, which often combine text and images. It is relevant to mention here that, social media being an unregulated platform, sometimes also has instances of discriminatory, offensive and hateful content being posted. Such content adversely affects the online well-being of the users. Therefore, it is very important to develop computational models to automatically detect such content so that appropriate corrective action can be taken. Accordingly, there have been research efforts on automatic detection of such content focused mainly on the texts. However, the fusion of multimodal data (as in memes) creates various challenges in developing computational models that can handle such data, more so in the case of low-resource languages. Among such challenges, the lack of suitable datasets for developing computational models for handling memes in low-resource languages is a major problem. This work attempts to bridge the research gap by providing a large-sized curated dataset comprising 5,054 memes in Hindi-English code-mixed language, which are manually annotated by three independent annotators. It comprises two subtasks: (i) Subtask-1 (Binary classification involving tagging a meme as misogynous or non-misogynous), and (ii) Subtask-2 (multi-label classification of memes into different categories). The data quality is evaluated by computing Krippendorff's alpha. Different computational models are then applied on the data in three settings: text-only, image-only, and multimodal models using fusion techniques. The results show that the proposed multimodal method using the fusion technique may be the preferred choice for the identification of misogyny in multimodal Internet content and that the dataset is suitable for advancing research and development in the area.
Nitrate ingestion blunts the increase in blood pressure during cool air exposure: a double-blind, placebo-controlled, randomized, crossover trial
Authors: Rowland Samantha N. , O’Donnell Emma , James Lewis J. , Da Boit Mariasole , Fujii Naoto , Arnold Josh T. , Lloyd Alex B. , Eglin Clare M. , Shepherd Anthony I. , Bailey Stephen J.
Published: April 2024

Compared with normothermic conditions, acute nitrate ingestion increased plasma [nitrite], a substrate for oxygen-independent nitric oxide generation, to a greater extent during cool air exposure. Systolic blood pressure was increased during cool air exposure in the placebo condition with this cool-induced blood pressure increase attenuated after acute nitrate ingestion. These findings improve our understanding of environmental factors that influence nitrate metabolism and the efficacy of nitrate supplementation to lower blood pressure.
A Case Report of Dextrocardia with Situs Inversus: A Rare Condition and Its Clinical Importance
Authors: Deshimo Girma , Abebe Haile , Damtew Getiye , Demeke Enguday , Feleke Seife
Published: April 2024

Situs inversus totalis (SIT) is a rare medical condition characterized by a complete mirror-image reversal of the normal positioning of the internal organs. Aristotle initially described situs inversus in animals, while Fabricius first characterized it in humans. Although the specific cause is uncertain, there is evidence of autosomal recessive and X-linked inheritance. Before seeking treatment for an unrelated ailment, many people with SIT are unaware of their distinct anatomy, as in our case. The presented case is a 30-year-old female patient from Central Ethiopia, presented to Hakim Gizaw Teaching Hospital outpatient department of medicine with the complaint of right-sided anterior chest pain for five days. Clinically, the apical beat was heard in the right 5th intercostal space. After undergoing an electrocardiogram (ECG), echocardiogram, chest X-ray, and abdominal ultrasound, she was diagnosed with situs inversus totalis. The clinical implications of SIT encompass challenges in diagnosis and procedures, potential congenital cardiac abnormalities, considerations for organ transplantation, and clinical decision-making, particularly in emergency scenarios. Key Clinical Messages. This case highlights the clinical implications of dextrocardia with situs inversus totalis, emphasizing the importance of awareness for accurate diagnosis, procedural challenges, and informed clinical decision-making. Understanding this rare condition is crucial for providing appropriate medical care and to navigate potential complications in affected individuals.
Bonding Effectiveness of Saliva-Contaminated Monolithic Zirconia Ceramics Using Different Decontamination Protocols
Authors: Demir Necla , Genc Ozge , Akkese Ipek Balevi , Malkoc Meral Arslan , Ozcan Mutlu
Published: April 2024

Objective. This research study investigated the effect of new decontamination protocols on the bonding capacity of saliva-contaminated monolithic zirconia (MZ) ceramics cemented with two different monomer-containing self-adhesive resin cements. Materials and Methods. Standardized tooth preparations (4 mm. axial height) were performed for eighty human maxillary premolars under constant water cooling system. Eighty monolithic zirconia crowns (Whitepeaks Supreme Monolith) (n=8/10 groups) were manufactured by CAD-CAM. Specimens were kept in the artificial saliva at pH=7.3 for 1 minute at 37°C except control groups. The specimens have not been prealumina blasted and grouped according to cleaning methods and resin cements: control groups (C) (no saliva contamination+GPDM+4‐META (N) (CN) and 10-MDP (M) containing resin cement (CM), alumina blasted AL+GPDM+4‐META (ALN) and 10-MDP containing resin cement (ALM), zirconium oxide containing universal cleaning agent (IC) applied+GPDM+4‐META (N) (ICN) and 10-MDP containing resin cement (ICM), pumice (P) applied+GPDM+4‐META (PN) and 10-MDP containing resin cement (PM), and air-water spray (AW) applied+GPDM+4‐META (AWN) and 10-MDP containing resin cement (AWM)). Monobond Plus was applied to all surfaces for 40 seconds before cementation. The thermal cycle was applied at 5,000 cycles after cementation. The crowns were tested in tensile mode at a speed of 1 mm/min. The mode of failure was recorded. SEM examinations were carried out at different magnifications. Data were analyzed using rank-based Kruskal-Wallis and Mann–Whitney tests. Results. No significant differences were found between the surface treatments and between the two types of resin cements. Interaction effects between surface treatments and resin cements were found to be significant by two-way ANOVA analysis. ICM group resulted in significantly better bond strength results compared with CN. ICM was found to result in better bond strength results compared with PM. The combination of universal cleaning agent and 10-MDP containing resin cement had significantly the highest cementation bond strength values. The increasing order of mean tensile bond strength values of decontamination protocols was C<AW<P<AL<IC. The mean tensile bond strength of 10-MDP containing resin cement was slightly higher than GPDM+4‐META containing resin cement. Conclusions. Universal cleaning agents can be preferred as an efficient cleaning method with 10-MDP-containing cement after saliva contamination for better adhesive bond strength of 4 mm crown preparation height of monolithic zirconia ceramics.
Supplementary Table S6 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: April 2024

Supplementary Table S6
RNA-seq analysis of MTRX-849-resistant tumor nodules from KCL mice
Supplementary Table S3 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: April 2024

Supplementary Table S3
RNA-seq analysis of H2030 and H2122 cells treated with MRTX-849 or vehicle for 48 hr
Cancer and the Metaorganism
Authors: Zitvogel Laurence , Kroemer Guido
Published: April 2024

Pathogenic shifts in the gut microbiota are part of the “ecological” alterations that accompany tumor progression and compromise immunosurveillance. The future management of health and disease including cancer will rely on the diagnosis of such shifts and their therapeutic correction by general or personalized strategies, hence restoring metaorganismal homeostasis.
The Cancer Spectrum Theory
Authors: Lee Hwa-Young , Song Minkyo , Stopsack Konrad H. , Peng Cheng , Phipps Amanda I. , Wang Molin , Ogino Shuji , Sasamoto Naoko , Ugai Tomotaka
Published: April 2024

Biological characteristics of tumors are heterogeneous, forming spectra in terms of several factors such as age at onset, anatomic spatial localization, tumor subtyping, and the degree of tumor aggressiveness (encompassing a neoplastic property spectrum). Instead of blindly using dichotomized approaches, the application of the multicategorical and continuous analysis approaches to detailed cancer spectrum data can contribute to a better understanding of the etiology of cancer, ultimately leading to effective prevention and precision oncology. We provide examples of cancer spectra and emphasize the importance of integrating the cancer spectrum theory into large-scale population cancer research.
Glioblastoma: Not Just Another Cancer
Authors: Fine Howard A.
Published: April 2024

This commentary urges a paradigm shift in how we approach research and drug development for glioblastoma, reimagining it as an aberrant brain-like organ, distinct from other cancers, to inspire innovative treatment strategies and interdisciplinary collaboration, addressing the minimal progress in extending glioblastoma patient survival despite years of research and investment.
The Virtual Child
Authors: Gilbertson Richard J. , Behjati Sam , Böttcher Anna-Lisa , Bronner Marianne E. , Burridge Matthew , Clausing Henrick , Clifford Harry , Danaher Tracey , Donovan Laura K. , Drost Jarno , Eggermont Alexander M.M. , Emerson Chris , Flores Mona G. , Hamerlik Petra , Jabado Nada , Jones Andrew , Kaessmann Henrick , Kleinman Claudia L. , Kool Marcel , Kutscher Lena M. , Lindberg Gavin , Linnane Emily , Marioni John C. , Maris John M. , Monje Michelle , Macaskill Alexandra , Niederer Steven , Northcott Paul A. , Peeters Elizabeth , Plieger-van Solkema Willemijn , Preußner Liane , Rios Anne C. , Rippe Karsten , Sandford Peter , Sgourakis Nikolaos G. , Shlien Adam , Smith Pete , Straathof Karin , Sullivan Patrick J. , Suvà Mario L. , Taylor Michael D. , Thompson Emma , Vento-Tormo Roser , Wainwright Brandon J. , Wechsler-Reya Robert J. , Westermann Frank , Winslade Shannon , Al-Lazikani Bissan , Pfister Stefan M.
Published: April 2024

We are building the world's first Virtual Child–a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will “develop cancer” that we will subject to unlimited virtual clinical trials that pinpoint, predict, and prioritize potential new treatments, bringing forward the day when no child dies of cancer, giving each one the opportunity to lead a full and healthy life.
Using the National Cancer Plan to Drive Innovation in Cancer Research
Authors: Rathmell W. Kimryn
Published: April 2024

The NCI director presents her vision of the National Cancer Plan as an integrated framework that can help drive innovation in cancer research to speed progress toward ending cancer as we know it.
Small Extracellular Vesicle piR-hsa-30937 Derived from Pancreatic Neuroendocrine Neoplasms Upregulates CD276 in Macrophages to Promote Immune Evasion
Authors: Zhong Yuan , Tian Ye , Wang Yan , Bai Jian’an , Long Qin , Yan Lijun , Gong Zhihui , Gao Wei , Tang Qiyun
Published: April 2024

The role of PIWI-interacting RNAs (piRNA) in small extracellular vesicles (sEV) derived from pancreatic neuroendocrine neoplasms (PNEN) in the tumor microenvironment (TME) remains unexplored. We used multiplex IHC to analyze the expression of CD68, CD276 (B7H3), and CD3 on PNEN. CD276+ tumor-associated macrophages (TAM) were more abundant in tumor tissues than nontumor tissues and negatively correlated with T-cell infiltration. Serum sEV piRNA sequencing was performed to identify piRNAs enriched in patients with PNEN. We then investigated the function and mechanism of sEV piR-hsa-30937 in the cross-talk between tumor cells and macrophages in the PNEN TME. PNEN-derived sEV piR-hsa-30937 targeted PTEN to activate the AKT pathway and drive CD276 expression. CD276+ macrophages inhibited T-cell proliferation and IFNγ production. piR-hsa-30937 knockdown and anti-CD276 treatment suppressed progression and metastasis in a preclinical model of PNEN by enhancing T-cell immunity. Thus, our data show that PNEN-derived sEV piR-hsa-30937 promotes CD276 expression in macrophages through the PTEN/AKT pathway and that CD276+ TAMs suppress T-cell antitumor immunity. sEV piR-hsa-30937 and CD276 are potential therapeutic targets for immunotherapy of PNEN.
FIGURE 2 from Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
Authors: Cottrell Kyle A. , Ryu Sua , Pierce Jackson R. , Soto Torres Luisangely , Bohlin Holly E. , Schab Angela M. , Weber Jason D.
Published: April 2024

Validation of putative protein–protein interactions identified by proximity labeling. Immunoprecipitation of DHX9 (A–C), DDX54 (D–E), or DDX17 (F–G) followed by immunoblot for ADAR in breast cancer cell lines. Immunoblot of immunoprecipitation eluates and inputs from SK-BR-3 (A, D, and F), MCF-7 (B, E, and G), and MDA-MB-231 (C). Input represents 5% of the lysate used for immunoprecipitation. The IgG lanes represent immunoprecipitation eluates from pulldown with anti-rabbit IgG antibody. The lanes labeled DHX9, DDX54, and DDX17 indicate the eluates from immunoprecipitation with antibodies against those proteins, respectively. The IgGHC label indicates the band corresponding to the IgG heavy chain from the antibody used for immunoprecipitation. Uncropped immunoblots for A–G can be found in Source Data Figures. Immunofluorescence for ADAR1 and DHX9 (H), DDX54 (I), or DDX17 (J) in SKBR3 or MCF-7.
Human papillomavirus genotype distribution patterns in Zimbabwe; is the bivalent vaccine sufficient?
Authors: Marembo Takudzwa , Fitzpatrick Megan Burke , Dube Mandishora Racheal S.
Published: April 2024

Background: Vaccination against Human papillomavirus (HPV) is the primary preventative strategy that has been shown to reduce the burden of HPV related diseases. Zimbabwe introduced the bivalent vaccine (HPV 16/18) in the vaccination program targeting prepubescent girls in 2018. This review is an analysis of the distribution of HPV genotypes from various studies conducted in Zimbabwe to ascertain the effectiveness of the bivalent vaccine and make recommendations for future HPV vaccine choices.

Summary: Zimbabwean studies have mostly reported on cervical HPV in the urban areas. The most frequent HPV genotypes from cervical sites were 16, 18, 33, 35, 45, 56 and 58. These were identified from samples with normal cytology, pre-cancer and invasive cervical cancer. The few studies that have been done in rural areas reported HPV 35 as the most frequent cervicovaginal genotype. From the anal region of individuals reporting for routine screening, HPV 16, 18, 35 52 and 58 were the most frequent. A study on genital warts identified HPV 6, 11, 16, 40, 51and 54. In a study on children with recurrent respiratory papillomatosis (RRP), HPV 6 and 11 were the most common and HPV 35 was also identified in these children. There is no available published data on HPV distribution in head and neck cancers in Zimbabwe.

Key messages: Given that 83% of cervical cancers in Zimbabwe are caused by HPV 16/18, the bivalent vaccine could cover a significant proportion of HPV related cervical cancer. The current limitation of the bivalent vaccine is its failure to prevent benign lesions such as genital warts and RRP or all cervical cancer cases in Zimbabwe. For the prevention of most HPV related conditions, the nonavalent vaccine would be the most appropriate option for the Zimbabwean population. Currently there is no vaccine that includes HPV 35, yet this genotype was frequently identified in HPV related diseases. Vaccine developers may need to consider HPV 35 when manufacturing the next generation HPV vaccines. Furthermore, boys should also be included in HPV vaccination programs to improve herd immunity, as well as prevent RRP and HPV-related head and neck cancers.
Brain-Heart Axis and the Inflammatory Response: Connecting Stroke and Cardiac Dysfunction
Authors: Chen Xiaosheng , Gu Jiajie , Zhang Xiaojia
Published: April 2024

Background: In recent years, the mechanistic interaction between the brain and heart has been explored in detail, which explains the effects of brain injuries on the heart and those of cardiac dysfunction on the brain. Brain injuries are the predominant cause of post-stroke deaths, and cardiac dysfunction is the second leading cause of mortality after stroke onset. Summary: Several studies have reported the association between brain injuries and cardiac dysfunction. Therefore, it is necessary to study the influence on the heart post-stroke to understand the underlying mechanisms of stroke and cardiac dysfunction. This review focuses on the mechanisms and the effects of cardiac dysfunction after the onset of stroke (ischemic or hemorrhagic stroke). Key Messages: The role of the site of stroke and the underlying mechanisms of the brain-heart axis after stroke onset, including the hypothalamic-pituitary-adrenal axis, inflammatory and immune responses, brain-multi-organ axis, are discussed.
Bibliometric study of association rule-market basket analysis
Authors: Yanti Roaida , Elquthb Jundi Nourfateha , Rachmadewi Ira Promasanti , Qurtubi Qurtubi
Published: April 2024

Association rule-market basket analysis (AR-MBA) is a data mining technique for finding distinguished relationship patterns from a collection of items. The application of AR-MBA is also increasingly widespread, starting from retail and hotels to hospitals. So, bibliometrics related to AR-MBA needs to be done to reveal what research opportunities can be later carried out by reviewing and analyzing publications about AR-MBA. 91 bibliographies in 1 decade from 2012-2022 were collected using Harzing's Publish or Perish (PoP). VOSviewer is also employed to map authorship and publication topic trends. This paper is innovative because it identifies trends and future research directions in data mining, specifically in association with AR-MBA. The findings show publication productivity, top authors, types of publications, annual topic trends within a decade, term distribution, most cited and most influential articles, and research gaps that can be opportunities for further research.
A cost-effective counterfeiting prevention method using hashing, QR code, and website
Authors: Hossain Monir , Begum Momotaz , Das Bimal Chandra , Uddin Jia
Published: April 2024

In this paper, we proposed a cost-effective software method to prevent counterfeiting where we used a website, quick-response (QR) code, and hashing. At the early stage of the product, the system will create a unique ID and a password with a random password generator for all products. Then, the password hash would be stored along with the ID in the database. At the same time, the password would be converted into a QR code for each product. The manufacturer will collect the QR code and ID and attach them to the product. When consumers attempt to verify the product, they will enter the website provided by the manufacturer and scan the QR code. After applying the same hash used before, the code will be checked on the database. After a successful check, the product entity will be destroyed and the life of the product ends. This paper contains flowcharts, figures, cost estimation, and a detailed explanation of the system. As it only requires domain hosting, thus the fixed cost of the system is so lower to bear for small enterprises also. We built a similar system using PHP, HTML, JavaScript for websites, and MYSQL for databases.
Enhanced human activity recognition through deep multi-layer perceptron on the UCI-HAR dataset
Authors: Hossain Md. Anwar , Ray Sajeeb Kumar , Islam Naima , Alamin Alamin , Hasan Mirza AFM Rashidul
Published: April 2024

Using the UCI-HAR dataset, this paper examines human activity recognition (HAR) from the perspectives of data science and artificial intelligence. The primary objective is to present and evaluate the effectiveness of a multi-layer perceptron (MLP) model, concentrating on six different activity categories. We train and assess the MLP model using the UCI-HAR dataset, contrasting its results with those of convolutional neural networks (CNN). The MLP model shows competitive results, attaining an amazing 97% validation and testing accuracy, highlighting its efficiency for smaller datasets. An extensive study is carried out to assess the model's adaptation to a larger Motion Sense dataset using confusion matrices and cross-entropy, the model shows robustness with an accuracy of 89%. The MLP model performs admirably, demonstrating its capacity to pick up complex patterns. Results from comparative analysis with CNN are competitive, especially when dealing with smaller datasets. The suggested MLP model shows up as a practical and efficient way to advance HAR techniques. Its remarkable performance and versatility not only show its usefulness in real-world scenarios but also point to interesting directions for further study in the area of HAR.
A non-isolated PFC bridgeless SEPIC-Cuk converter with adaptive PI controller for induction motor
Authors: Suguna R. , Tamil Selvi S. , Mohana Sundaram K. , Katta Pradeep
Published: April 2024

In general, the induction motor (IM) is extremely nonlinear in nature and frequency dependent. In most cases, the power generated by the IM has a low power factor (PF), which exhibits detrimental effect on the extent to which the whole transmission and distribution system functions. Since there exists more current harmonics as an outcome of minimized PF, the efficiency of the power system suffers due to transmission line heating and voltage distortion characteristics. Therefore, this paper proposes a power factor correction (PFC) method to overcome the aforementioned issues. Here, by the utilization of AC-DC bridgeless SEPIC-Cuk converter, the power quality is improved by reducing reactive power consumption and enabling better control of voltage and current outputs. To maintain the stable DC link voltage with reduced ripples, the adaptive proportional-integral (PI) controller is used in this work. The three-phase voltage source inverter (VSI) transitioning function is controlled by cascaded fuzzy logic (CFL) controller, which is also utilized for regulating the speed of the three-phase IM. Implementing the proposed control strategy improves power quality significantly by reducing total harmonic distortion (THD). The proposed system is simulated in the MATLAB platform and the attained outcomes, it is clear that the proposed system is highly effective.
Analysis, design, and control of standalone PV based boost DC-AC converter
Authors: Nayak Jnanaranjan , Kumar Sunil , Sahu Pradeep Kumar , Jena Satyaranjan
Published: April 2024

This paper presents a new control scheme for a boost DC–AC converter which is used for solar power applications. The proposed DC-AC converter configuration can produce an AC voltage level across the output or load side greater than input DC voltage based on the operating duty cycle. Generally, the conventional DC-AC converter or voltage source inverter (VSI) generates AC voltage which is less than input DC voltage. Maintaining a constant voltage across the load with improved dynamic performance is challenging for anyone for the solar photovoltaic (PV) system. A dual-loop sliding mode control is proposed for the boost VSI to address the above issues. The proposed controller has robust in nature against the wide fluctuation in the plant or load parameters. The design, analysis and control of the boost DC-AC converter are briefly discussed in this paper. This topology can be broadly used in solar powered uninterruptible power supply (UPS) where boosting operation is essential for low voltage solar PV system. This topology eliminates the DC boosting power processing stage which leads an improved efficiency of the overall system. The MATLAB/Simulink results are presented to highlight the above issues.
Investigating the effects of corrosion parameters on the surface resistivity of transformer’s insulating paper using a two-level factorial design
Authors: Azlan Nur Farhana Mohd , Ghani Sharin Ab , Khiar Mohd Shahril Ahmad , Chairul Imran Sutan , Din Mohamad Nazri Mohamad
Published: April 2024

The integrity of the insulation in oil-filled power transformers, shunt reactors, and high voltage bushings can be affected when copper dissolves in the insulating oil and then deposits onto the paper insulation. The presence of dissolved copper in the oil increases dielectric losses, while copper deposition significantly improves the conductivity of the paper insulation. Various factors, including temperature, oxygen, sulfur groups, passivators, and ageing time, have been found to contribute to the acceleration of corrosion activity in transformer insulating oils. Unfortunately, there is a lack of extensive research focused on systematically analysing and measuring the impact of corrosion-related factors on the dissolution of copper in transformer insulating oils and the deposition of copper onto solid insulation surfaces (Kraft paper). Therefore, this study aims to thoroughly examine the effects of corrosion factors on copper and sulfur deposition on Kraft paper insulation when it is submerged in transformer mineral oil (TMO). Using a two-level (2k) factorial design, we investigated three crucial factors: i) oil temperature, ii) elemental sulfur concentration, and iii) ageing time. It is worth mentioning that the results obtained from the two-level factorial design indicate that the surface resistivity is primarily affected by the temperature of the oil. This factor alone explains a significant 38.68% of the observed variation. In order to improve predictability, a regression model was created to estimate the surface resistivity of TMO-impregnated paper insulation. This model takes into account factors such as oil temperature, elemental sulfur concentration, and ageing time.
Cost optimization of electricity in energy storage system by dynamic programming
Authors: Mishra Debani Prasad , Routray Bhabesh , Pattanayak Nitesh , Shekhar Priyansu , Behera Pratyus Ranjan , Salkuti Surender Reddy
Published: April 2024

This paper presents a dynamic programming solution for the cost optimization of an electric storage system. The objective is to minimize the total cost of meeting electricity demand over a specified time interval, considering energy constraints and costs. The proposed algorithm efficiently determines the optimal energy discharge and charge strategies for the storage system, resulting in reduced overall costs. The effectiveness and efficiency of the algorithm are demonstrated through various test cases, highlighting its potential for real-world applications in energy storage systems and electric grid management. It also provides an overview of different types of electrical storage systems, review recent research on optimization techniques for energy storage, and examines recent studies on the optimization of electrical storage systems for specific applications, such as peak load shaving and grid stability. Through this comprehensive analysis, we hope to shed light on the current state of the field and identify areas for further research and improvement.
Short-circuit current analysis of DC distribution system in a ship with non-electric propulsion
Authors: Kurniawan Adi , Gumilang Ahlur Roi Novanto , Sarwito Sardono , Budianto Firman , Kurniawan Akhmad Reinaldy
Published: April 2024

Converting conventional AC radial shipboard distribution system to DC system has been recognized as a potential high impact solution to reduce ship’s fuel consumption. As big ships in Indonesia commonly use low voltage AC (LVAC) distribution system an effort to apply low voltage direct current (LVDC) distribution system without replace the propulsion system is a plausible choice. However, technical and economical investigations are required before recommendation to convert the shipboard distribution system to LVDC is officially launched. In this study, technical aspect in the term of short-circuit current is discussed. The goal of this study is to analyze how much the impact on the short-circuit current when LVDC system replaces LVAC system. The impact may affect the feasibility of LVDC system as the short-circuit current in a system dictate the scheme and capacity of the protection devices. Numerical simulations on a sample vessel are performed to obtain the profile of maximum short-circuit currents on all panels. The results show that the utilization of LVDC system decreases the short-circuit current by 10 times. Further investigations on the economic aspect needs to be performed to give clearer view of the feasibility of the LVDC system.
Power quality conditioning using two-level buck inverter based DSTATCOM
Authors: Suneetha P. , Subbaramaiah K. , Visali Nagalamadaka
Published: April 2024

A two-level buck inverter is derived from the voltage source inverter, by replacing the additional power devices and suitable combination of inductor circuits respectively. Novel isolated buck inverter, featuring each-phase conversion and soft-switching within wide operation range, is developed. An optimized control strategy is employed to realize isolated buck conversion. By utilizing the buck inverter, the voltage stress on the power devices and passive components, the self-supported capacitor and filter inductance, is reduced to the half of the output voltage. Moreover, it is proven that the thyristor-controlled series capacitor (TCSC) equipped with a well-designed distributed static compensator (DSTATCOM) can effectively improve source current harmonics reduction, power factor correction in the source side, load compensation, regulation of load voltage and upholding constant voltage across the DC-link capacitor. In order to verify the effectiveness of the proposed DSTATCOM, its performance is compared with the two level DSTATCOM. The extensive simulations are carried out using MATLAB/Simulink to analyze the results. Experimental results using dSPACE-1104 prototype verify the appropriate DSTATCOM.
Voltage stability index: a review based on analytical method, formulation and comparison in renewable dominated power system
Authors: Kanojia Sarika Sanjay , Suthar Bhavik N.
Published: April 2024

In an interconnected complex power system network voltage stability evaluation is indispensable to guarantee secure power system operation. To further increase the system performance and to make the system safer assessment, the voltage stability improvement is obligatory. In the various literature different voltage security assessment method using the voltage stability index has been presented. Different lists proposed in literature can be utilized to realize the weak buses and weak transmission lines to enacting the countermeasures against issues of voltage insecurity. Additionally, the arrangement and measuring of inexhaustible assets, on the web and disconnected observing of force framework and the measure of load to be shed at whatever point essential. This paper shows a survey on the different voltage stability index from various perspectives. The audit results on various record gives a far and wide logical to perceive the impending works in this field and to choose the best index for variety of applications such as voltage security assessment, renewable energy integration, distributed generation (DG) placement and sizing, online monitoring of the power system, and shedding of load.
Use of analytical hierarchy process for selecting and prioritizing islanding detection methods in power grids
Authors: Abu Sarhan Mohammad , Bien Andrzej , Barczentewicz Szymon
Published: April 2024

One of the problems that are associated to power systems is islanding condition, which must be rapidly and properly detected to prevent any negative consequences on the system's protection, stability, and security. This paper offers a thorough overview of several islanding detection strategies, which are divided into two categories: classic approaches, including local and remote approaches, and modern techniques, including techniques based on signal processing and computational intelligence. Additionally, each approach is compared and assessed based on several factors, including implementation costs, non-detected zones, declining power quality, and response times using the analytical hierarchy process (AHP). The multi-criteria decision-making analysis shows that the overall weight of passive methods (24.7%), active methods (7.8%), hybrid methods (5.6%), remote methods (14.5%), signal processing-based methods (26.6%), and computational intelligent-based methods (20.8%) based on the comparison of all criteria together. Thus, it can be seen from the total weight that hybrid approaches are the least suitable to be chosen, while signal processing-based methods are the most appropriate islanding detection method to be selected and implemented in power system with respect to the aforementioned factors. Using Expert Choice software, the proposed hierarchy model is studied and examined.