bluuebunny/crossref_metadata_2025 huggingface dataset:
CRIMINALLY-LEGAL COUNTERMEASURES TO CRIMES IN THE SPHERE OF HOUSING AND COMMUNAL SERVICES: PROBLEMS OF THEORY AND PRACTICE
Authors: Степанова М.А. , Маркова Ю.В.
Published: June 2024

В силу отсутствия единства взглядов как в  теории, так и  в судебно-следственной практике, вопросы привлечения к  уголовной ответственности за преступления в  сфере жилищно-коммунального комплекса, вызывают повышенный интерес. Жилищно-коммунальное хозяйство – это поле нашей ежедневной жизни, наши ежеминутные заботы и вопросы, которые требуют безотлагательного решения. Многие если не знают, то слышали о  работе домоуправляющих компаний и товариществ собственников жилья, а также о преступлениях, которые совершаются в этой сфере. Разбираться в нюансах совершенных преступлений необходимо для совершенствования всей системы ЖКХ, а также для эффективной деятельности сотрудников правоохранительных органов. Изучение судебно-следственной практики по уголовным делам о  преступлениях в сфере ЖКХ позволяет сделать вывод о том, что действия виновных лиц квалифицируются как мошенничество (ст. 159 УК РФ), присвоение и растрата (ст. 160 УК РФ), кража (ст. 158 УК РФ), злоупотребления полномочиями (ст. 201 УК РФ), злоупотребления должностными полномочиями (ст. 285 УК РФ), нецелевое расходование бюджетных средств (ст. 285.1 УК РФ), получение взятки (ст.  290 УК  РФ) и  другие. В публикации авторы обращают особое внимание на проблемы, возникающие при решении вопроса о привлечении лиц, использующих свое служебное положение, к уголовной ответственности, что впоследствии затрудняет применение уголовного закона.

Due to a lack of consensus in both theory and judicial practice, issues of criminal responsibility for crimes in the sphere of housing and communal services cause an increased interest. Housing and communal services is a field of our daily life, our constant concerns and issues that require urgent solutions. Many people are aware of the work of house management companies and homeowners' associations and the crimes committed in this area. It is necessary to understand the nuances of the crimes to improve the entire system of housing, as well as provide efficient activities of law enforcement officers. Investigations of judicial practice of criminal cases of housing and communal services allow to conclude that the actions of perpetrators are considered as fraud (article 159 of the Russian Criminal Code), misappropriation and embezzlement (article 160 of the Russian Criminal Code), theft (art. 158 of the Russian Criminal Code), abuse of power (article 201 of the Russian Criminal Code), abuse of official powers (article 285 of the Russian Criminal Code), misappropriation of budgetary funds (article 285.1 of the Russian Criminal Code), taking bribes (article 290 of the Russian Criminal Code) and others. The authors pay special attention to the problems arising from the decision of a question on attraction of individuals using their official position, criminal responsibility, which in consequence hinders the application of criminal law.
ENTREPRENEURIAL ACTIVITY OF MEDICAL ORGANIZATIONS: CHALLENGES AND OPPORTUNITIES IN THE DIGITAL ECONOMY
Authors: Хрячков А.Д.
Published: June 2024

В статье представлен анализ вызовов и  возможностей, с  которыми сталкиваются медицинские организации в эпоху цифровой экономики. Рассматриваются проблемы, связанные с  необходимостью модернизации технической базы, обеспечением конфиденциальности данных, преодолением цифрового разрыва, адаптацией к  изменяющимся потребностям пациентов и соблюдением законодательства о защите данных. Предлагаются стратегии успешного внедрения цифровых технологий и подчеркивается важная роль правового регулирования в развитии предпринимательской деятельности в цифровую эпоху.

The article presents an analysis of the challenges and opportunities faced by medical organizations in the era of the digital economy. The author examines the problems associated with the need to modernize the technical base, ensure data confidentiality, bridge the digital divide, adapt to the changing needs of patients and comply with data protection legislation. The article also suggests strategies for the successful implementation of digital technologies and emphasizes the important role of legal regulation in the development of entrepreneurship in the digital age.
Students’ Perceptions of Google Tools on Supporting Self-Regulated Learning in an Asynchronous Course
Authors:   Centre for Instructional Technology and Multimedia, Universiti Sains Malaysia, Penang, Malaysia, Rabu Siti Nazleen Abdul
Published: June 2024

The study investigated students’ perceptions regarding the use of an integrated set of five Google Tools (i.e., Google Classroom, Google Sites, Google Slides, Google Docs, and Google Forms) in creating a Computer-Mediated Communication (CMC) environment for self-regulated learning in an asynchronous course. Using a mixed-method convergent research design, a single online questionnaire comprising close- and open-ended questions was used to collect quantitative and qualitative data. Purposive sampling was employed, and two cohorts of undergraduate education majors were chosen. 114 participants completed the questionnaire. Quantitative data from Likert items were subjected to descriptive analysis and supplemented with students’ open-ended narratives, while specific qualitative data were examined with inductive thematic analysis. The quantitative findings revealed that students positively perceived the integrated set of Google Tools in terms of its usefulness, ease of use, confirmation, satisfaction, and continuance intention for supporting their self-regulated learning. The qualitative findings highlight students’ predominantly positive perception of Google Classroom as a Learning Management System (LMS) for self-regulated learning, stemming from its ease of use, efficient interface, and notification and reminder features. Minimal instances of other perceptions were also observed. The study proposes practical implications for educators to facilitate students’ online self-regulated learning by leveraging and integrating these five Google Tools in forming a CMC environment. Recommendations include allocating adjustment time and practice tasks to help students familiarize with the tools for smooth online learning.
Arctic policy of Türkiye
Authors: Vernigora Alina
Published: June 2024

In 2015, Ankara applied to participate in the work of the Arctic Council as an observer state and was expectedly rejected. The article is devoted to the main directions of Turkey's Arctic policy, as well as the main problems of its implementation. The author concludes that this direction is peripheral in Ankara's foreign policy and serves the general purpose of increasing its own presence in world politics and forming the image of a global power, rather than pursuing any specific goals.
The American electorate in the 2024 elections
Authors: Popov Nikolay
Published: June 2024

Based on the results of public opinion polls, the article examines the structure of the American electorate in the 2024 election campaign and the main problems of American society that will affect the voters’ choice. The composition of the electorate is characterized by an increase in the proportion of young cohorts – millennials and "generation Z", an increase in the number of people with college-level education, the growing number of Spanish speakers, primarily from Latin American countries. The problems that have become the main ones in shaping the choice of voting are government inefficiency, inflation and migration across the southern border. The issue of abortion will continue to play an important role in the campaign, and the problem of the armed conflict in Ukraine and American aid to this country will play a growing role.
Keywords, morpheme parsing and syntactic trees: features for text complexity assessment
Authors: Morozov Dmitry A. , Smal Ivan A. , Garipov Timur A. , Glazkova Anna V.
Published: June 2024

The text complexity assessment is an applied problem of current interest with potential application in the drafting of legal documents, editing textbooks, and selecting books for extracurricular reading. The methods for generating a feature vector when automatically assessing the text complexity are quite diverse. Early approaches relied on easily calculable quantities, such as the average length of a sentence or the average number of syllables per word. With the development of natural language processing algorithms, the space of used features is expanding. In this work, we examined three groups of features: 1) automatically generated keywords, 2) information about the features of morphemic word parsing, and 3) information about the diversity, branching, and depth of syntactic trees. The RuTermExtract algorithm was utilized to generate keywords, a convolutional neural network model was used to generate morphemic parses, and the Stanza model, trained on the SynTagRus corpus, was used to generate syntax trees. We conducted a comparison using four different machine learning algorithms and four annotated Russian-language text corpora. The corpora used differ both in the domain and markup paradigm, due to which the results obtained more objectively reflect the real relationship between the characteristics and the text complexity. The use of keywords performed worse on average than the use of topic markers obtained using latent Dirichlet allocation. In most situations, morphemic characteristics turned out to be more effective than previously described methods for assessing the lexical complexity of a text: the frequency of words and the occurrence of word-formation patterns. The use of an extensive set of syntactic features allowed, in most cases, to improve the quality of work of neural network models in comparison with the previously described set.
Artefatos acessíveis, multissensoriais e digitais em museus orientado ao público com deficiência visual
Authors: De Melo Brito Rocha Luís Cláudio , Chalegre Virgínia
Published: June 2024

Los museos son espacios plurales y educativos que posibilitan la expansión del conocimiento, a partir de la relación y reflexión entre elementos artísticos y culturales.
Creatividad solidaria. Mujeres que relatan
Authors: De Vecchi Cecilia
Published: June 2024

Mujeres que relatan fue creada con el objetivo de que la lectura y la escritura puedan llegar de forma gratuita a las mujeres.
THE RELATIONSHIP BETWEEN THERAPEUTIC COMMUNICATION AND THE SLOGAN IMPLEMENTATION OF KNOW, CHECK, AND, ASK BEFORE DRUG ADMINISTRATION ON ANXIETY LEVEL OF PATIENT’S FAMILY IN THE EMERGENCY ROOM OF PKU MUHAMMADIYAH SUKOHARJO HOSPITAL
Authors: Apriliyanti Fitria , Pebru Nurlaily Ari , Murharyati Atiek
Published: June 2024

Introduction: Emergency treatment often causes anxiety and fear for patients and their families. One way to reduce anxiety is through therapeutic communication. In commemoration of World Patient Safety Day (WPSD) on September 17, 2022, WHO and the Ministry of Health announced slogans about before providing and receiving drugs namely Know (understand drugs and their side effects), Check (check according to the 5 correct drugs), and Ask (ask for information that is not understood). The purpose of this research is to determine the relationship between therapeutic communication and the application of the slogan Know, Check, and Ask before drug administration on the anxiety level of the patient's family in the emergency room of PKU Muhammadiyah Sukoharjo Hospital. Methods: The type of research was quantitative with a descriptive Corelative design and a cross-sectional approach. The sampling used the Quota Sampling technique based on Yount's formula (1999) 5% of the population with 57 sample respondents. The research was conducted in June 2023. Results: The Spearman Rank test analysis obtained a p-value = 0.000 (<α = 0.05), meaning that there is a relationship between therapeutic communication and the implementation of the slogan of Know, Check, and Ask before administering medication to the anxiety level of the patient's family in the IGD room of PKU Muhammadiyah Sukoharjo Hospital. Conclusions: The application of therapeutic communication with the slogan Know, Check, and Ask before drug administration should be maintained properly because it is related to the anxiety level of the patient's family.
THE RELATIONSHIP BETWEEN SELF-CONTROL AND CYBERBULLYING BEHAVIOR
Authors: Dhian Sulistyowati Arlina , Murtana Agus , Fitria Eri Desviana Ajeng
Published: June 2024

Introduction: Self-control is an individual’s ability to restrain themselves or direct themselves in a better direction with existing norms. Individuals with high self-control can control themselves well when faced with various difficult situations, such as impolite behavior, harsh words, and even aggressive behavior on social media. Cyberbullying is a negative action carried out by an individual or a group of people by sending text messages, photos, meme images, and videos to someone's social media account to mock, insult, humiliate, discriminate, or persecute that individual. Cyberbullying perpetrators are predominantly teenagers. The current increase in the use of internet technology magnifies the risk of the cyberbullying behavior phenomenon among teenagers. This research aims to determine the relationship between self-control and cyberbullying behavior among students at SMP N 2 Wedi. Methods: This research employed a quantitative design with a cross-sectional study and a correlational approach. Proportionate stratified random sampling was applied as the sampling technique, with a total of 159 responses considering the predetermined inclusion and exclusion criteria. This study incorporated self-control and cyberbullying behavior questionnaires, while Spearman rank correlation was employed for data analysis. Results: the research findings indicate that students have moderate levels of self-control, accounting for 65.4%, and moderate levels of cyberbullying behavior, accounting for 67.3%. The data analysis results show that the p-value was 0.000 < 0.05, with a correlation coefficient value of -0.836. This suggests there is a significantly negative relationship between self-control and cyberbullying among female students at SMP N 2 Wedi. The higher the level of self-control, the lower the cyberbullying behavior.  Conclusions: There is a relationship between self-control and cyberbullying behavior.
The novelty design method in lightweight structures with low effective elastic modulus
Authors: Ghahramanzadeh Asl Hojjat , Karaman Derya
Published: June 2024

Lightweight structures are of great interest in industrial areas such as automotive, aerospace, and biomedical due to their lightness, and superior mechanical performance. The advantages of lightweight structures are increased with the spread of additive manufacturing and design them in various geometries. Beam-based structures and triply periodic minimal surface structures are currently used to extend these advantages. In this study, it is aimed to create die models of beam-based structures in order to contribute to the geometric diversity for lightweight structures. By designing the die lattice structures of the beam-based structures, the comparison of the mechanical performance of basic lattice and die lattice structures with the same porosity was carried out. For FCC, CFCC, and Octet-Truss lattice structures, basic lattice and die lattice structures are designed on scaffolds in 5x5x5 array with 50%, 60%, 70%, and 80% porosity. Numerical data were obtained for Ti6Al4V with compression tests simulated by applying pressure in the -y direction. According to numerical analyses, the effective elastic modulus decreased due to the increased porosity in both structure models. The CFCC and Octet Truss scaffolds have different force transmission performances. Likewise, this situation is observed in die lattice structures, but the force transmission with the surfaces reveals the difference of the structures. The effective elastic modulus of basic lattice structure with 80% porosity of the Octet Truss structure is approximately twice that of the die lattice structure. Thus, the use of die lattice structures will provide advantages for the design of lightweight structures with low elastic modulus.
Influence of Glycerol on the Surface Morphology and Crystallinity of Polyvinyl Alcohol Films
Authors: Kovtun Ganna , Casas David , Cuberes Teresa
Published: June 2024

The structure and physicochemical properties of polyvinyl alcohol (PVA) and PVA/glycerol films have been investigated by Fourier-transform infrared spectroscopy (FT-IR), X-ray Diffraction (XRD), thermogravimetry/differential thermal analysis (TG/DTA), and advanced scanning probe microscopy (SPM). In the pure PVA films, SPM allowed us to observe ribbon-shaped domains with a different frictional and elastic contrast, which apparently originated from a correlated growth or assembly of PVA crystalline nuclei located within individual PVA clusters. The incorporation of 1.0 wt.% glycerol led to modification in shape of those domains from ribbon-like in pure PVA to rounded in PVA/glycerol 1.0 wt.% films; changes in the relative intensities of the XRD peaks and a decrease of the amorphous halo in the XRD pattern were also detected, while the DTA peak corresponding to the melting point remained at almost the same temperature. For higher glycerol content, FT-IR revealed additional glycerol-characteristic peaks presumably related to the formation of glycerol aggregates, and XRD, FT-IR, and DTA all indicated a reduction in crystallinity. For more than 2.0 wt.% glycerol, the plasticization of the films complicated the acquisition of SPM images without tip-induced surface modification. Our study contributes to the understanding of crystallinity in PVA and how it is altered by a plasticizer such as glycerol.
RGB Color Model: Effect of Color Change on a User in the VR Art Gallery using Polygraph
Authors: Drofova Irena , Richard Paul , Fajkus Martin , Valasek Pavel , Sehnalek Stanislav , Adamek Milan
Published: June 2024

This paper presents computer and color vision research focusing on human color perception in VR environments. A VR art gallery with digital twins of original artworks is created for this experiment. In this research, the field of colorimetry and the application of CMYK and RGB color models are applied. The interrelationships of the two colors models are applied to create a color modification of the VR art gallery environment using C# Script procedures. This color-edited VR environment works with a smooth change of color tone in a given time interval. At the same time, a sudden change in the color of the RGB environment is defined in this interval. This experiment aims to record a user's reaction embedded in a VR environment and the effect of color changes on human perception in a VR environment. The research uses lie detector sensors that record the physiological changes of the user embedded in VR. Five sensors are used to record the signal. An experiment on the influence of the user's color perception in a VR environment using lie detector sensors has never been conducted. This research defines the basic methodology for analyzing and evaluating the recorded signals from the lie detector. The presented text thus provides a basis for further research in the field of colors and human color vision in a VR environment and lays an objective basis for use in many scientific and commercial areas.
A Bptf Inhibitor That Interferes with the Multidrug Resistance Pump to Sensitize Triple Negative Breast Cancer Cells to Chemotherapy
Authors: Sinanian Melanie M. , Rahman Afshan , Elshazly Ahmed M. , Neely Victoria L. , Nagarajan Balaji , Kellogg Glen E. , Risinger April L. , Gewirtz David A.
Published: June 2024

Triple negative breast cancer (TNBC) is associated with a generally poor prognosis due to its highly aggressive and metastatic nature, lack of targetable receptors, as well as the frequent development of resistance to chemotherapy. We previously reported that AU1, a small molecule developed as an inhibitor of BPTF (bromodomain PHD finger containing transcription factor), was capable of sensitizing preclinical models of triple negative breast cancer to chemotherapy, in part via the promotion of autophagy. In studies reported here, we identify an additional property of this compound, specifically that sensitization is associated with inhibition of the P-glycoprotein efflux pump. In silico molecular docking studies indicate that AU1 binds to active regions of the efflux pump, in a manner consistent with inhibition of pump function. This work identifies a novel chemical structure that can influence multidrug efflux, an established mechanism of drug resistance in triple negative breast cancer, that has not yet been successfully addressed by clinical efforts.
Development of The Tabletop Hologram for Spatial Visualization: Application in The Field of Architectural and Urban Design
Authors: Phuc Tam Do Le , Coffin Matteo , Gentet Philippe , Mirzaevich Narzulloev Oybek , Ugli Jumamurod Aralov Farhod , Hwang Leehwan , Dongsu Yi , Lee Seunghyun
Published: June 2024

In the history, architects, engineers or artists traditionally visualized architectural, urban planning, urban design, or landscape design projects with physical models in a smaller scale to represent their ideas. The biggest problems of traditional materialistic models are the long production time and limitation of mobility. Thanks to advancements in digital technology, 3D models can now be generated easily from 2D blueprints using computer software. However, eventually the digitalized approach could not replace the whole industry of making physical models, because of a lack of stereoscopic 3D imaging of space and structures. In this study, we discuss two points: the normal procedure of visualizing 3D models in urbanism and architecture design projects; and proposal of the stereographic hologram visualization for 3D models created with CHIMERA hologram printer as a new approach to solve all the problems in spatial projects visualization of both digitalized and physical models. The experiment's results indicate that tabletop holograms' visualization quality can potentially replace traditional methods in the near future. Moreover, the input data for this method can be seamlessly integrated into current architectural and urban design workflows, making holograms a promising approach for 3D immersive content in this field.
Distinct Plasma Metabolomic and Gut Microbiome Profiles After GDM Diet Treatment: Implications for Personalized Dietary Interventions
Authors: Sugino Kameron Y. , Hernandez Teri L. , Barbour Linda A. , Kofonow Jennifer M. , Frank Daniel N. , Friedman and Jacob E.
Published: June 2024

Gestational diabetes mellitus (GDM) triggers alterations in the maternal gut microbiome. Alongside metabolic shifts, microbial products may impact clinical factors and influence pregnancy outcomes. Here, we performed two separate analyses to integrate the maternal microbiome-metabolomic differences from a subset of the “Choosing Healthy Options in Carbohydrate Energy” (CHOICE) study. Women diagnosed with GDM were randomized to a diet higher in complex carbohydrates (CHOICE, n=18, 60% complex carbohydrate/25% fat/15% protein) or a conventional GDM diet (CONV, n=16, 40% carbohydrate/45% fat/15% protein). All meals were provided, diets were eucaloric, and fiber content was similar. CHOICE diet was associated with increases in TMAO, lysophosphotidylcholines, indoxyl sulfate, and several triglyceride (TG) species, while CONV diet was associated with higher plasma hippuric acid, aspartic acid, betaine, glutamic acid, indole propionic acid, and indoleacetic acid, suggesting that differences in lipid metabolism and tryptophan utilization pathways are linked to specific maternal diets. We also identified two latent metabolic groups not associated with either diet treatment: one metabolome associated with higher fasting glucose, and the other associated with higher fasting TGs after 7 weeks on either diet. Our study underscores the importance of utilizing dietary approaches to optimize maternal-fetal health outcomes in GDM treatment.
Toward the Development of Garlic Varieties: The First Attempts
Authors: Licea-Moreno Ricardo Julián , Rodríguez Haro Ángeles , Marín Martínez Juan Antonio
Published: June 2024

Aimed to obtain purple garlic varieties, 360 bolting bulbs from the Protected Geographical Indication (PGI) “Las Pedroñeras” were selected for their size, and the presence of abundant external scales. After a further selection, 243 out of the 360 bulbs were discarded due to undesired characteristics, as light purple color, high number of small cloves, cloves affected by Fusarium spp. and mites, among other. It was stablished that each bulb would give rise to a family. Thus, 117 families were planted under a random design during season 2021-2022. Either physiological, morphological and phenological traits were assessed for each family, and the affectations by pest and pathogens were also controlled. After the assessment of this trial, 103 out 117 families remained in the program, and were used for the establishment of a second trial the next season. Unlike the first trial, after the evaluations only 23 families remained in the program. There was observed a high variability for most of traits, with a great influence of families. The phenotypic behavior of families was significative influenced by environment, highlighting the need of their assessment under different environmental conditions. The high variability registered for the target sample, opens the possibility to select new garlic varieties from this PGI.
A Real-World Safety Profile in Neurological, Skin, and Sexual disorders of Antiepileptic Drugs Using Pharmacovigilance Database of the Korea Adverse Event Reporting System (KAERS)
Authors: Kim DaJeong , Lee Sukhyang
Published: June 2024

This study aims to examine the safety profile of antiepileptic drugs (AEDs) using real-world data, with a focus on neurological, skin, and sexual/reproductive disorders. Data were collected from AED-caused reports in the Korea Adverse Event Reporting System Database (KAERS-DB) from 2012 to 2022. Totally, 46,963 adverse drug reaction (ADR)-drug pairs were analyzed. At the system organ class level, the most frequently reported classes for sodium channel blockers (SCBs) were skin (37.9%), neurological (16.7%), and psychiatric disorders (9.7%). However, for non-SCBs, these were neurological (31.2%), gastrointestinal (22.0%), and psychiatric disorders (18.2%). The most common ADRs induced by SCBs were rash (17.8%), pruritus (8.2%), and dizziness (6.7%). In contrast, non-SCBs induced dizziness (23.7%), somnolence (13.0%), and nausea (6.3%). Among the most commonly reported ADRs, rash, pruritus, and urticaria occurred on average two days later with SCBs compared to non-SCBs. Sexual/reproductive disorders were reported at a frequency of 0.23%. SCBs were reported as the cause more frequently than non-SCBs (59.8% vs. 40.2%, Fisher’s exact test, p<0.0001). Based on real-world data, we identified the safety profiles of AEDs. AED-induced ADRs exhibited different patterns depending on the mechanism. Therefore, it is important to establish different pharmacovigilance strategies to ensure proper monitoring.
Impact of Thickness of Pd/Cu Membrane on Performance of Biogas Dry Reforming Membrane Reactor Utilizing Ni/Cr Catalyst
Authors: Nishimura Akira , Ito Syogo , Ichikawa Mizuki , Kolhe Mohan Lal
Published: June 2024

This study focuses on a biogas dry reforming to produce H2. Biogas contains CO2 of 40 vol% approximately, indicating that the efficiency of the power generation is reduced because of the smaller heating value compared with a natural gas. The authors have proposed the combination system consisting of biogas dry reforming reactor and solid oxide fuel cell (SOFC). Since a biogas dry reforming is an endothermic reaction, this study adopts a membrane reactor which can be operated by causing the non-equilibrium state with H2 separation from the reaction space. This study aims to clarify the impact of thickness of Pd/Cu membrane on the characteristics of the biogas dry reforming membrane reactor using Pd/Cu membrane and Ni/Cr catalyst. The impact of the operation temperature, the molar ratio of CH4:CO2 and the differential pressure between the reaction chamber and the sweep chamber on the characteristics of the biogas dry reforming membrane reactor using Pd/Cu membrane and Ni/Cr catalyst is examined changing the thickness of Pd/Cu membrane. As a result, the highest concentration of H2 is 122711 ppmV which is obtained in case of CH4:CO2 =1:1 at the reaction temperature of 600 ℃ and the differential pressure of 0 MPa using the Pd/Cu membrane whose thickness of 40 m.
Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS)
Authors: Mundorf Anna Katharina , Semmler Amelie , Heidecke Harald , Schott Matthias , Steffen Falk , Bittner Stefan , Lackner Karl J. , Schulze-Bosse Karin , Pawlitzki Marc , Meuth Sven Guenther , Klawonn Frank , Ruhrländer Jana , Boege Fritz
Published: June 2024

Post-acute COVID-19 vaccination syndrome (PACVS) is distinguished from the normal post-vaccination state by altered receptor antibodies (Semmler et al. Vaccines 2023, 11, 1642). Here, we explore the symptoms registry and standard serum markers acquired in the above study to delineate the disease phenotype of PACVS. Symptoms reported by the participants overlapped with established complex dysautonomia syndromes (ME/CFS, POTS, MCAS, SFN). However, many participants were qualified for several (131/191) or none (31/191) of these syndromes. Unbiased clustering (modified Jaccard index) revealed a prevalent cross-cohort symptomatology of malaise and chronic fatigue (> 80% of cases). Overlapping clusters of (i) peripheral nerve dysfunction, dysesthesia, motor weakness, pain, vasomotor dysfunction, (ii) cardiovascular impairment, and (iii) cognitive impairment, headache, optic, oculo-motoric and acoustic dysfunctions were also frequently represented. Conspicuous serum markers encompassed increases in interleukins 6 and 8 and low fT3 levels (> 80%), IgG-subclass imbalances and impaired iron-storage (> 50%), and increases in sNFL (> 30%). Serum markers were not correlated to specific symptoms or symptom clusters. A single and unique cause (i. e. SARS-CoV-2 vaccination) is improbable to trigger several distinct etiologies. Therefore, the symptoms and serological features observed in our study cohort probably represent facets of a single complex syndrome.
E-Waste Management in Serbia, Focusing on the Possibility of Applying Automated Separation Using Robots
Authors: Nišić Dragana , Lukić Branko , Vukićević Arso , Gordić Zaviša , Pantelić Uros
Published: June 2024

To encourage proper waste management from electrical and electronic devices (e-waste), it is necessary to invest heavily in the development of recycling technologies. One way to improve the process is to automate separating the shredded parts of e-waste using a robot. This paper's literature review, utilizing the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) framework, showcases potential robotic technologies for e-waste separation. However, the intricate design of these devices can pose significant challenges in their implementation. Various legal, organizational, and sociological obstacles have left Serbia's e-waste management practice underdeveloped, resulting in an unsatisfactory recycling rate. In this paper we examined the possibility of using robots on the precise example of recycling refrigerators in a recycling center in Eastern Serbia, concluding that such a solution would have multiple positive effects, both on the employees and the working environment, on the operations of the recycling center itself, and on increasing the e-waste recycling rate in the country.
First Description of a Thermophilic, Endophytic Aspergillus brasiliensis Strain from a Volcanic Ecosystem: Genomic Analysis and Plant Growth Benefits
Authors: Martirena-Ramírez Amanda , Serrano-Gamboa J.Germán , Pérez-Llano Yordanis , Zenteno-Alegría Claribel Orquídea , Iza-Arteaga Mario León , Sánchez-Carbente María del Rayo , Fernández-Ocaña Ana María , Batista Ramon , Foch-Mallol Jorge Luis
Published: June 2024

Abstract: Thermophilic fungi constitute an interesting study model for understanding ecologi-cal mechanisms of adaptation in diverse environments and have attractive toolboxes with a wide range of biotechnological applications. This work describes for the first time an endophytic and thermophilic strain of Aspergillus brasiliensis that was isolated in the crater of the active volcano "El Chichonal" in Mexico. The average temperature of the collection site was around 60 °C and the soil pH was moderately acidic. The complete genome of A. brasiliensis E_15.1 was sequenced and assembled in about 37 Mb of genomic DNA. We performed a comprehensive phylogenomic anal-ysis for the precise taxonomic identification of this species as a novel strain of Aspergillus brasil-iensis. Likewise, the predicted coding sequences were classified according to various functions including Carbohydrate-Active Enzymes (CAZymes), biosynthetic gene clusters of secondary metabolites (BGCs), and metabolic pathways associated with plant growth promotion. Among the functional traits identified was the degradation of chitin, chitooligosaccharides, xylan, and cellulose, as well as the biosynthesis of clavaric acid, a triterpene with antitumor activity due to its ability to inhibit Farnesyl-protein transferase. In addition to the genomic analysis, a set of en-zymatic assays confirmed the thermostability of extracellular xylanases, cellulases of A. brasili-ensis E_15.1. Our findings suggest that the enzymatic repertoire of A. brasiliensis E_15.1 has a high potential for industrial application due to its thermostability and can promote plant growth at high temperatures. Finally, this strain constitutes an interesting source of terpenoids with pharmacological activity.
TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary Ciliary Dyskinesia
Authors: Piatti Gioia , Girotto Giorgia , Concas Maria Pina , Braga Leonardo , Ambrosetti Umberto , Aldè Mirko
Published: June 2024

(1) Background: Several chronic respiratory diseases could be a risk factor for acquiring SARS-CoV-2 infection: among them, Primary Ciliary Dyskinesia (PCD) is a rare (about 1:10.000) inherited ciliopathy (MIM 242650) characterized by recurrent upper and lower respiratory tract infections due to a dysfunctioning of the respiratory cilia; We aimed to investigate if some polymorphisms of the TAS2R38 bitter taste receptor correlate with an increased prevalence of SARS-CoV-2 infection and severity of symptoms in a cohort of PCD subjects; (2) Methods: Patients answered several questions about possible SARS-CoV-2 infection, experienced symptoms and vaccinations; in case of infection, they also filled out a SNOT-22 and ARTIQ questionnaires; (3) Results: Forty PCD adult patients (mean age 36.6 ± 16.7 years, 23 females) participated to the study, out of which 30 % had tested positive for COVID-19 during the last four years; most of them reported a mildly symptomatic disease. We found no differences in age or sex, but a statistic significant difference (p=0.03) was observed in body mass index (BMI), that was higher in the COVID-acquired group (23.2 ± 3.3 vs 20.1 ± 4.1 kg/m2). Genotyping for TAS2R38 polymorphisms showed a prevalence of 28.6% PAV/PAV, 48.6% PAV/AVI and 22.8% AVI/AVI individuals in our cohort. In contrast to our hypothesis, we did not observe a protective role of PAV allele towards SARS-CoV-2 infection; (4) Conclusions: Our findings suggest that subjects with PCD may not be at increased risk of severe outcomes from COVID-19 and the TAS2R38 bitter taste receptor genotype type does not affect SARS-CoV-2 infection.
Fundamental Constraints to the Logic of Living Systems
Authors: Solé Ricard , Kempes Christopher P. , Corominas-Murtra Bernat , De Domenico Manlio , Kolchinsky Artemy , Lachmann Michael , Libby Eric , Saavedra Serguei , Smith Eric , Wolpert David
Published: June 2024

It has been argued that the historical nature of evolution makes it a highly path-dependent process. Under this view, the outcome of evolutionary dynamics could have resulted in organisms with different forms and functions. At the same time, there is ample evidence that convergence and constraints strongly limit the domain of the potential design principles that evolution can achieve. Are these limitations relevant in shaping the fabric of the possible? Here, we argue that fundamental constraints are associated with the logic of living matter. We illustrate this idea by considering the thermodynamic properties of living systems, the linear nature of molecular information, the cellular nature of the building blocks of life, multicellularity and development, the threshold nature of computations in cognitive systems, and the discrete nature of the architecture of ecosystems. In all these examples, we present available evidence and suggest potential avenues towards a well-defined theoretical formulation.
Implementasi Restitusi terhadap Kekerasan Seksual Kepada Anak Menurut Hukum Positif di Indonesia
Authors: Wardhani Devita Wisnu , Pranawa Burham
Published: June 2024

Sistem peradilan pidana Indonesia saat ini telah mengalami banyak perubahan, dengan penekanan yang lebih besar pada pelaksanaan hak-hak terdakwa dan korban kejahatan. proses pelaksanaan undang-undang ini, terdapat beberapa kendala yang masih membutuhkan dukungan hukum dan kepastian hukum. Lalu Pengertian ganti kerugian dalam konteks hak korban adalah pelaku kejahatan membayar ganti rugi kepada korban kejahatan. Selanjutnya yang menjadi metode penelitian  yang digunakan penulis dalam artikel ini bersifat analisis deskriptif, yaitu hanya menggambarkan permasalahan secara umum yang diambil dari buku, jurnal maupun media lain yang relevan. Adapun yang akan penulis kaji dalam artikel ini adalah bagaimanakah Implementasi Restitusi Terhadap Kekerasan Seksual Kepada Anak Menurut Hukum Positif di Indonesia. Hasilnya Implementasi Restitusi Terhadap Kekerasan Seksual Kepada Anak Menurut Hukum Positif di Indonesia belum maksimal karena masih terdapat beberapa kendala diantaranya adalah belum adanya undang-undang khusus yang mengatur mengenai restitusi ini sehingga hal tersebut membuat apparat penegak hukum mempunyai tafsir yang berbeda beda.
Identifying Key Learning Algorithm Parameter of Forward Feature Selection to Integrate with Ensemble Learning for Customer Churn Prediction
Authors: Tasneem Sabahat , Younas Muhammad , Shafiq Qasim
Published: June 2024

The Telecommunication has been facing fierce growth of customer data and competition in the market for a couple of decades. Due to this situation, an analytical strategy of proactive anticipation about customer churn and their profitable retention is inevitable for Telecommunication companies. To nip this problem in the bud, a lot of research work has been conducted in the past, but still the previously introduced churn prediction models possess their own limitations, such as high dimensional data with poor information and class imbalance, which turn into barriers while being implicated in real life to attain accurate and improved predictions. This study has been conducted, basically, to identify the key Learning Algorithm parameter of Forward Feature Selection (FFS) for dimensionality reduction which can be further integrated with class Imbalance Handling Technique and Ensemble Learning (EL) to attain improved accuracy. The core objective of this study is to turn an imbalanced dataset into a balanced one for Ensemble Learning (EL) Model of Customer Churn Prediction (CCP). This study concluded that Logistic Regression (LR) based Forward Feature Selection (FFS) can outperform with Oversampling Class Imbalance Handling Techniques and Ensemble Learning (EL) by scoring 0.96% accuracy, which is the highest accuracy against benchmark studies. The resulting methodology has been named as the Logistic Regression Learning based Forward Feature Selection for ensemble Learning (LRLFFSEL) and applied over Orange dataset with 20 features and 3333 instances. In future this methodology can be evaluated over a bigger dataset and combined with some data optimization techniques to improve its accuracy.
El Estado Social y los derechos sociales como nudo crítico de la crisis constitucional chilena
Authors: Almagro Castro David , Díaz Bravo Enrique
Published: June 2024

The State formula is one of the recurring issues of Chilean public law since the establishment of the Political Constitution of 1980. The doctrinal and social discussion revolves around two opposing poles: maintaining the main lines of the system established in said Political Charter or constitutionalizing for the first time and expressly the option of the Social and Democratic rule of law. In this sense, the social outbreak of October 2019 has revealed the exhaustion of the subsidiary State imposed by the 1980 constitutional text and the need to build a system that allows for using the grotesque gaps of social and economic inequality that affect Chilean society. The political and legal operators who have led the constituent process under development have agreed on the Welfare State formula as one of the twelve constitutional bases of the new social pact. A different issue, and the core of discord, will be the real and effective scope of the Welfare State clause and its main normative projection: social rights. The thesis that supports this article is clear: the formal constitutionalization of the Welfare State, as a legal and political mandate to the public powers, is the essential step for the materialization of social rights as authentic subjective rights.
Fake news, influência na formação da opinião pública e impactos sobre a legitimidade da decisão pública
Authors: Valle Vivian Cristina Lima López , Fernández Ruiz María Guadalupe , Buttner Marcielly
Published: June 2024

Technological transformations related to Artificial Intelligence (AI) impact administrative law as algorithms process information that leads to a new understanding of reality. AI applied to social networks is not neutral, especially when it comes to the circulation of fake news and the modulation of will, generating impacts that go beyond the segmentation of society. The focus of the analysis is centered on the importance of studying the impact of AI applied to social networks on the formation of will, which will directly have repercussions regarding the exercise of citizenship and, consequently, democracy. The objective is to analyze the use of AI to form public opinion with a focus on the dissipation of fake news and how this process impacts the legitimacy of public administration and its processes. Fake news causes dysfunctionality in Public Administration based on its basic principles: legality, impersonality, morality, publicity and efficiency. The need to regulate the matter is justified based on the effects of disinformation, classified as fatal to democracy: reduction of the population's cognitive capacity, influence on the electoral process, harm to competing political versions and silencing of dissonant voices, impoverishment of debate and multiplicity of worldviews.
NaOH Treatment Revolutionizes Strength of Fiber Composites Globally
Authors: Pamungkas Wahyu Aji , Widodo Edi
Published: June 2024

This study investigates Sansivera fiber-reinforced composite materials treated with 15% NaOH alkaline liquid for different durations using the hand lay-up method. The aim is to determine the optimal treatment duration that enhances the tensile properties of these composites. Results indicate that longer NaOH treatment periods positively impact tensile strength, with the best outcomes observed at 15% treatment for 8 hours. These findings contribute to improving the mechanical performance of Sansivera fiber composites for various industrial applications.
 
Highlight: 

Sansivera composites strengthen with 15% NaOH for 8 hours.
Hand lay-up method enhances industrial applicability.
Optimal treatment duration for Sansivera fibers is highlighted.

 
 
Keyword:  Sansivera fiber composites, NaOH alkaline treatment, Tensile strength enhancement, Hand lay-up method, Industrial applications
Isolated External Jugular Thrombophlebitis Secondary to Acute Pharyngitis: A Case Report and a Review of the Literature
Authors: Ezeh Uche C. , Tesema Naomi , Hasnie Sukaina , Kahn Philip J. , April Max M.
Published: June 2024

Background
External Jugular Thrombophlebitis (EJT) is a rare clinical phenomenon with few reports in the literature, especially in the pediatric population. This is a report of an unusual case of right-sided EJT in a pediatric patient secondary to acute pharyngitis with sinusitis most prominent on the left side.
Case presentation:
A 13-year-old presented to the emergency department with worsening upper respiratory infectious (URI) symptoms and facial swelling, cough, throat pain, and emesis. The patient had traveled to Switzerland and received amoxicillin for strep throat 6 weeks before this hospitalization. Physical examination revealed nasal purulence, allodynia over the right side of the face without overlying erythema, and oropharyngeal exudate. CT scan revealed left-sided predominate sinusitis and right external jugular vein thrombosis. Blood cultures confirmed the presence of group A streptococcus infection. Treatment included IV antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), IV steroids, and anticoagulation. Follow-up imaging demonstrated improvement in thrombosis, cellulitis, and sinus disease. The patient was discharged on antibiotics for 6 weeks and anticoagulation for 10 weeks. Follow-up imaging at 6 months revealed no EJT, and medications were discontinued.
Conclusions
EJT is a rare condition, and to our knowledge, no reports of EJT with sinusitis most pronounced on the contralateral side have been published. Physicians will benefit from noting clinical signs of EJT such as facial edema, headache, erythema, and palpable neck mass, especially if these symptoms occur with URI symptoms refractory to treatment. The use of anticoagulation is controversial for internal jugular vein thrombosis, and while no guidelines for EJT exist, anticoagulation is likely not necessary save for severe complications.
The applications of circulating cell-free DNA for oral squamous cell carcinoma patients as non-invasive diagnostics of structural variants and fusions
Authors: Frenkel-Morgenstern Milana , Bhattacharya Mahua , Yaniv Dan , Yosef Eyal , Tzelnick Sharon , Detroja Rajesh , D'Souza Dylan , Baum Eliezer Gideon , Mizrachi Aviram , Bachar Gideon
Published: June 2024

Circulating cell-free DNA (cfDNA) has been widely used as a prognostic marker for different cancers. In this study, we used cfDNA from oral squamous cell carcinoma (OSCC) patients to study various correlation factors that could improve the disease early-stage diagnostics and/or prognosis. We found that OSCC patient cfDNA concentration can serve as an indicator of tumor stage, malignancy, and survival prognosis. Deep genome sequencing of cfDNA revealed genomic alterations, such as copy number variations, fusion gene identification, and viral integrations. Copy number variation analysis suggested correlation with amplification and deletion in chromosome 1 at loci 1q, 2q, 3p, 3q and 8q22. Moreover, at these loci, amplification of TP53, PIK3CA and other genes related to keratinization in OSCC patients were observed. In addition, we identified the novel fusion gene, TRMO-TRNT1 ‘chimera’, in seven high-grade tumor samples. The parental genes of this chimera, TRMO and TRNT1, are known to play roles in tRNA modification and DNA repair, respectively. Therefore, our study indicates that liquid biopsy may thus serve as a sensitive tool to study OSCC patient genomic alterations by exploring cfDNA circulating in the plasma, by means of an easy-to-use blood test. Finally, we detected integrations of human papilloma virus, simian virus, and enterovirus in the OSCC samples, that may point to the origins of OSCC.