bluuebunny/crossref_metadata_2025 huggingface dataset:
Integration of Gender-Affirming Primary Care and Peer Navigation With HIV Prevention and Treatment Services to Improve the Health of Transgender Women: Protocol for a Prospective Longitudinal Cohort Study (Preprint)
Authors: Lama Javier R , Mayer Kenneth H , Perez-Brumer Amaya G , Huerta Leyla , Sanchez Hugo , Clark Jesse L , Sanchez Jorge , Reisner Sari L
Published: March 2019

BACKGROUND

Public health strategies are urgently needed to improve HIV disparities among transgender women, including holistic intervention approaches that address those health needs prioritized by the community. Hormone therapy is the primary method by which many transgender women medically achieve gender affirmation. Peer navigation has been shown to be effective to engage and retain underserved populations living with HIV in stable primary medical care.

OBJECTIVE

This study aims to assess the feasibility and acceptability of an integrated innovative HIV service delivery model designed to improve HIV prevention and care by combining gender-affirming primary care and peer navigation with HIV prevention and treatment services.

METHODS

A 12-month, nonrandomized, single-arm cohort study was implemented in Lima, Peru, among adult individuals, assigned a male sex at birth, who identified themselves as transgender women, regardless of initiation or completion of medical gender affirmation, and who were unaware of their HIV serostatus or were living with HIV but not engaged in HIV treatment. HIV-negative participants received quarterly HIV testing and were offered to initiate pre-exposure prophylaxis. HIV-positive participants were offered to initiate antiretroviral treatment and underwent quarterly plasma HIV-1 RNA and peripheral CD4+ lymphocyte cell count monitoring. All participants received feminizing hormone therapy and adherence counseling and education on their use. Peer health navigation facilitated retention in care by visiting participants at home, work, or socialization venues, or by contacting them by social media and phone.

RESULTS

Patient recruitment started in October 2016 and finished in March 2017. The cohort ended follow-up on March 2018. Data analysis is currently underway.

CONCLUSIONS

Innovative and culturally sensitive strategies to improve access to HIV prevention and treatment services for transgender women are vital to curb the burden of HIV epidemic for this key population. Findings of this intervention will inform future policies and research, including evaluation of its efficacy in a randomized controlled trial.

CLINICALTRIAL

ClinicalTrials.gov NCT03757117; https://clinicaltrials.gov/ct2/show/NCT03757117

INTERNATIONAL REGISTERED REPOR

DERR1-10.2196/14091
A Mobile Health Intervention for Prostate Biopsy Patients Reduces Appointment Cancellations (Preprint)
Authors: Balakrishnan Ashwin Sriram , Nguyen Hao G. , Shinohara Katsuto , Au Yeung Reuben , Carroll Peter R. , Odisho Anobel Y.
Published: March 2019

BACKGROUND

Inadequate patient education and preparation for office-based procedures often leads to delayed care, poor patient satisfaction, and increased costs to the healthcare system. We developed and deployed a mobile health (mHealth) reminder and education program for patients scheduled for transrectal prostate biopsy.

OBJECTIVE

We aimed to evaluate the impact of an mHealth reminder and education program on appointment cancellation rates, communication frequency, and patient satisfaction.

METHODS

We developed a text message-based (SMS) program with seven reminders containing links to web-based content and surveys sent over an 18-day period (14 days before through 3 days after prostate biopsy). Messages contained educational content, reminders, and readiness questionnaires. Demographic information, appointment cancellations or change data, and patient/provider communication events were collected for 6 months before and after launching the intervention. Patient satisfaction was evaluated in the post-intervention cohort.

RESULTS

The pre-intervention (n=473) and post-intervention (n=359) cohorts were composed of men of similar median age, racial/ethnic distribution, and living a similar distance from clinic. The post-intervention cohort had significantly fewer cancelled or rescheduled appointments (33.8% vs 21.2%, p<0.01) and fewer same day cancellations (3.8% vs 0.5%, p<0.01). There was a significant increase in pre-procedural telephone calls (0.6 vs. 0.8 calls/patient, p=0.02) in the post-intervention cohort, but not a detectable change in post-procedural calls. The mean satisfaction with the program was 4.5 out of 5 (SD 0.9).

CONCLUSIONS

An mHealth peri-procedural outreach program significantly lowered appointment cancellations and was associated with high patient satisfaction scores with a slight increase in pre-procedural telephone calls. This led to fewer under-utilized procedure appointments and high patient satisfaction.
The Use of Virtual and Immersive Technology in Creating Personalized Multisensory Spaces for People Living With Dementia (SENSE-GARDEN): Protocol for a Multisite Before-After Trial (Preprint)
Authors: Goodall Gemma , Ciobanu Ileana , Taraldsen Kristin , Sørgaard Jon , Marin Andreea , Drăghici Rozeta , Zamfir Mihai-Viorel , Berteanu Mihai , Maetzler Walter , Serrano J Artur
Published: March 2019

BACKGROUND

The number of people living with dementia is rapidly increasing. With dementia’s impact on memory, communication, and self-identity, it is important to identify ways of meeting individual needs of diagnosed individuals and their caregivers. This study will test a new intervention, SENSE-GARDEN, that integrates autobiographical music, films, pictures, and scents with innovative technology to create an immersive environment tailored specifically for the individual.

OBJECTIVE

The SENSE-GARDEN study is an Active Assisted Living Program–funded multicenter project. The primary objective of the study is to assess whether a personalized, innovative technology-based intervention can improve the well-being of older adults living with moderate to severe dementia. The study will also assess whether the intervention can improve coping and reduce burden in caregivers.

METHODS

A controlled before-after study design will be used. There will be 3 sites in 3 trial countries: Belgium, Norway, and Portugal. A total of 55 people with dementia (PWDs) will be recruited. All eligible participants for the study will be randomized into the intervention or control group. For the first three months of the study, all participants will receive the SENSE-GARDEN intervention. For the final month of the study, the intervention group will continue visits to the SENSE-GARDEN, and the control group will discontinue visits. A mixed-methods approach will be used, including the use of standardized outcome measures, quantitative physiological data, and qualitative interview data.

RESULTS

The trials commenced recruitment in August 2019, and all data is expected to be collected by the end of May 2020. A user-centered design process is underway, with results from the first phase of user interviews indicating that people with mild cognitive impairment, family caregivers, and professional caregivers consider the SENSE-GARDEN to be a potentially valuable tool in providing numerous benefits to dementia care. Feasibility testing of the SENSE-GARDEN has been completed and results are expected to be published in October 2019.

CONCLUSIONS

Findings from the SENSE-GARDEN trials will provide insights into the use of technology for personalizing interventions to the PWD. This will have potential implications on not only dementia research, but it may also have influences on care practice.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)

DERR1-10.2196/14096
Do Daily Fluctuations in Psychological and App-Related Variables Predict Engagement With an Alcohol Reduction App? A Series of N-Of-1 Studies (Preprint)
Authors: Perski Olga , Naughton Felix , Garnett Claire , Blandford Ann , Beard Emma , West Robert , Michie Susan
Published: March 2019

BACKGROUND

Previous studies have identified psychological and smartphone app–related predictors of engagement with alcohol reduction apps at a group level. However, strategies to promote engagement need to be effective at the individual level. Evidence as to whether group-level predictors of engagement are also predictive for individuals is lacking.

OBJECTIVE

The aim of this study was to examine whether daily fluctuations in (1) the receipt of a reminder, (2) motivation to reduce alcohol, (3) perceived usefulness of the app, (4) alcohol consumption, and (5) perceived lack of time predicted within-person variability in the frequency and amount of engagement with an alcohol reduction app.

METHODS

We conducted a series of observational N-of-1 studies. The predictor variables were measured twice daily for 28 days via ecological momentary assessments. The outcome variables were measured through automated recordings of the participants’ app screen views. A total of nine London-based adults who drank alcohol excessively and were willing to set a reduction goal took part. Each participant’s dataset was analyzed separately using generalized additive mixed models to derive incidence rate ratios (IRRs) for the within-person associations of the predictor and outcome variables. Debriefing interviews, analyzed using thematic analysis, were used to contextualize the findings.

RESULTS

Predictors of the frequency and amount of engagement differed between individuals, and for the variables 'perceived usefulness of the app' and 'perceived lack of time', the direction of associations also differed between individuals. The most consistent predictors of within-person variability in the frequency of engagement were the receipt of a daily reminder (IRR=1.80-3.88; P<.05) and perceived usefulness of the app (IRR=0.82-1.42; P<.05). The most consistent predictors of within-person variability in the amount of engagement were motivation to reduce alcohol (IRR=1.67-3.45; P<.05) and perceived usefulness of the app (IRR=0.52-137.32; P<.05).

CONCLUSIONS

The utility of the selected psychological and app-related variables in predicting the frequency and amount of engagement with an alcohol reduction app differed at the individual level. This highlights that key within-person associations may be masked in group-level designs and suggests that different strategies to promote engagement may be required for different individuals.
Um “tribunal orientado para a vítima”: o minimalismo de Nils Christie e as suas contribuições à justiça restaurativa
Authors: Riboli Eduardo Bolsoni
Published: March 2019

Partindo de ideias defendidas por Nils Christie como a noção de que toda pena é uma imposição intencional de dor, do “roubo do conflito” pelo Estado e da necessidade de integração comunitária para a criação e o reforço de valores sociais essenciais para a consolidação de um senso de justiça, o presente estudo tem como principal objetivo analisar pormenorizadamente as contribuições do referido autor à justiça restaurativa hodierna. Mediante uma pesquisa exploratória e descritiva realizada a partir de revisão bibliográfica e documental nacional e internacional, propomo-nos a analisar o problema da possibilidade de elaboração e aplicação de métodos alternativos de solução de conflitos criminais. Verificar-se-á como a vítima pode reconquistar o protagonismo no processo de solução de conflitos, através do que Christie denominou “tribunal orientado para a vítima”: um sistema humanitário de solução de conflitos criminais que possibilita à vítima a efetiva realização de justiça. Demonstrar-se-á como as ideias desenvolvidas pelo criminólogo norueguês influenciaram o paradigma atual de justiça restaurativa. Ao final, mediante abordagem crítica, analisar-se-á a compatibilidade da prática restaurativa portuguesa denominada mediação penal “de adultos” com os fundamentos do paradigma restaurativo e os ideais defendidos por Christie.
The inmate as a victim of the rise in the incarceration rate and the perception of insecurity in western society. A particular analysis of the Chilean case.
Authors: Cuneo Silvio
Published: March 2019

Often, the discussion about the victim in the penal process recognizes only the crime victim and doesn’t take into consideration that the inmate, the person deprived of liberty, might also be a victim of the criminal justice system. This paper analyses the issue of mass imprisonment with particular attention to the Chilean case. The excessive and selective use of the deprivation of freedom has become a controlling tool, filling our prisons with those excluded from society. After a general analysis, we will investigate the causes of mass imprisonment: the dismantling of the Welfare State (followed by tougher punishment) and punitive populism (result of a vindictive demagogic attitude). We believe that the selection by which it operates, the effects that it produces and the resulting advantages for the privileged minorities make this not only illegitimate but also intolerable in a democratic society. We will conclude with a realistic proposal, an alternative to mass imprisonment, compatible with respect for human dignity.
Editorial do dossiê “Meios alternativos, consenso e a participação da vítima no processo penal”: Participação da vítima na solução do conflito penal
Authors: Letelier Loyola Enrique
Published: March 2019

El resurgimiento de la víctima, como sujeto de interés para las ciencias criminológicas y el derecho penal,ha provocado la necesidad de cuestionarse si los tradicionales modelos de justicia penal son adecuados para satisfacer sus intereses, considerando que se trata de un protagonista del conflicto penal. Recogiendo diversas experiencias restaurativas y con apoyo de la victimología más moderna, los sistemas de justicia penal dejan de enfocarse solo en el castigo al infractor penal y se abren a la adopción de programas de justicia restaurativa, que reconocen en la víctima un sujeto titular del derecho a la reparación del daño.
El militarismo en la vida del mexicano hasta 1855
Authors: Fernández de Velasco Manuel
Published: March 2019

El autor plantea la necesidad de buscar las causas del militarismo en México hasta la revolución de Ayutla, a partir del análisis de lo indígena, lo español, lo mestizo, lo criollo y lo mexicano.
Conciencia jurídica del mexicano en la Revolución
Authors: Anaya Monroy Fernando
Published: March 2019

El artículo establece tres momentos por los que ha atravesado el proceso de estructuración de la conciencia jurídica del mexicano. Analiza igualmente los quebrantos y alteraciones que ha sufrido la conformación del conocimiento jurídico con posterioridad a la Revolución.
Reflexiones de Edmundo O'Gorman sobre la significación del triunfo de la República
Authors: Quirarte Martín
Published: March 2019

Martín Quirarte reflexiona sobre la aptitud crítica y el valor documental de la obra de Edmundo O'Gorman. De esta forma, analiza "El triunfo de la república en el horizonte de su historia", colaboración del mismo en el libro A cien años del triunfo de la república. Quirarte considera que el texto logra trascender la historiografía tradicional, evita las censuras y las concesiones y otorga magnitud y sentido plenos a la victoria de la República: derrotar tanto al enemigo externo como al interno y permitir a México cobrar su ser como nación.
La Decena Trágica
Authors: Valero Silva José
Published: March 2019

José Valero Silva comienza su ensayo con un recuento de lo ocurrido antes de la Decena Trágica. Menciona los fundamentos ideológicos de la Revolución Mexicana, la actuación y el significado de la figura de Francisco I. Madero así como los problemas que se presentaron en su gobierno y que lo enfrentaron con diversos grupos revolucionarios y no revolucionarios. El autor se concentra en Victoriano Huerta y explica que éste, ajeno al movimiento para derrocar al presidente, logra ponerse a la cabeza del mismo, lleva a cabo la contrarrevolución y reestablece el viejo régimen. Anexa una reproducción del Pacto de la Ciudadela.
Acta original de la designación del general Gildardo Magaña Cerda (1891-1939) como general en jefe del Ejército Libertador del Sur
Authors: Valero Silva José
Published: March 2019

El acta presentada contiene la designación de Gildardo Magaña como nuevo jefe revolucionario tras la muerte de Emiliano Zapata. El documento expresa la voluntad de los zapatistas de elegir a su nuevo líder por medio de sufragios exentos de corrupción para mantener el orden y ser congruentes con sus ideales.
Del Breviario al recinto de la gran historia. Estudio historiográfico
Authors: Quirarte Martín
Published: March 2019

Martín Quirarte hace una revisión historiográfica de la obra de José C. Valadés a través de los textos Breviario de historia de México e Historia del pueblo mexicano. Señala que el enfoque de dicho historiador radicó en el análisis de los hombres y las cosas. El autor afirma que el pensamiento de Valadés mostró una constancia ideológica en el estudio de la historia nacional.
Theodore V. Buttrey Jr. y Clyde Hubbard, A guidebook of Mexican coins, 1822 to date
Authors: Matute Álvaro
Published: March 2019

Reseña
Retrospectiva periodística alemana sobre los iniciadores de la independencia mexicana
Authors: Monjarás-Ruiz Jesús
Published: March 2019

Jesús Monjarás-Ruiz divulga el documento titulado Dos héroes revolucionarios americanos, en el cual se estudian las figuras del cura Hidalgo y de Morelos así como su aparición en los rotativos alemanes de mayor circulación. En la presentación, expone los motivos que lo indujeron a mostrar el escrito.
La Decena Trágica: una versión periodística alemana
Authors: Ortega y Medina Juan A.
Published: March 2019

Jesús Monjarás-Ruiz presenta y analiza 116 comunicados, en su mayoría telegramas, publicados en el periódico Kölnische Zeitung, de la ciudad de Colonia, Alemania, y editados por Walter Jacobs et al. El material que el autor considera abarca desde el levantamiento de Félix Díaz en Veracruz hasta el fin de la llamada Decena Trágica.
La crisis de México en el siglo XIX
Authors: Rodríguez O Jaime E.
Published: March 2019

A partir de una comparación entre el México independiente y el México republicano, Jaime Rodríguez hace un balance de los términos en los que concluyó la vida colonial para dar pie a la nación independiente. El autor considera capitalista a la sociedad novohispana del siglo XVIII, en contraste con la del siglo XIX, que se enfrentó a la guerra de Independencia, a invasiones extranjeras y a una crisis económica. Ésta última se incrementó ante la incapacidad del sector minero y textil de reactivarse así como por la falta de crédito en los bancos; hecho que provocó un declive en la capacidad exportadora de México y su consecuente dependencia del capital extranjero. El autor anexa cuadros con información económica.
Secularización: Estado e Iglesia en tiempos de Gómez Farías
Authors: Staples Anne
Published: March 2019

Anne Staples estudia el proyecto de secularización de Valentín Gómez Farías, que buscaba crear un Estado moderno en donde se le diera prioridad al aspecto económico y político. Este esquema recrudeció la pugna entre Estado e Iglesia, particularmente cuando Gómez Farías intentó abolir los fueros constitucionales del clero para limitar su influencia política. La autora afirma que este proyecto no se concretó; sin embargo, indica que estableció las bases para una nueva relación entre las dos instituciones.
Polonia en la prensa de la capital mexicana, septiembre de 1939
Authors: Sánchez Lozano Mayte
Published: March 2019

Mayte Sánchez Lozano examina la prensa nacional durante el primer mes de la Segunda Guerra Mundial. Analiza los titulares de los diarios de mayor circulación en el país, en los cuales, se trata el tema de la ocupación de Polonia y las reacciones que produjo en los países europeos. Afirma que cada periódico percibía los acontecimientos de diferente manera y eso se reflejaba en el espacio que dedicaban a cada suceso. Anexa diversos artículos periodísticos y caricaturas.
Conciencia regional y poder central: ensayo sobre el pensamiento separatista yucateco en la primera mitad del siglo diecinueve
Authors: Urías Horcasitas Beatriz
Published: March 2019

Beatriz Urías Horcasitas expone el surgimiento de la conciencia regional en el México independiente. Analiza el pensamiento decimonónico en Yucatán y afirma que, tras la Colonia, la consolidación del Estado-nación se caracterizó por los problemas para conciliar los principios democráticos con la estructura de clases. La autora cree que la lucha de los separatistas yucatecos contra el poder central pudo estar vinculada con la Guerra de Castas, pues dicha rebelión incluyó a los indígenas en un discurso de igualdad mientras éstos eran marginados por la clase dominante.
Michoacán: tres décadas de historia militar
Authors: Sánchez Díaz Gerardo , Uribe Salas José Alfredo , Guzmán Ávila José Napoleón
Published: March 2019

Los autores examinan el desarrollo de las fuerzas armadas michoacanas durante las primeras tres décadas del México independiente ya que ha existido un vacío en el análisis de la relación ejército-sociedad y en el de la historia militar. Exponen cómo, durante ese periodo, la ausencia de un poder hegemónico central y la crisis económico-social causaron la movilización de milicias formadas por clases empobrecidas, las cuales, intentaron reestablecer el orden social de la región. Concluyen que el ejército derivado de las milicias locales se volvió un mecanismo para reprimir rebeliones agrarias y sociales.
Identidad cultural en la frontera entre México y los Estados Unidos
Authors: Moyano Pahissa Ángela
Published: March 2019

Ángela Moyano afirma que la existencia de una identidad nacional en la frontera norte de México es cuestionada debido al ímpetu de la influencia cultural estadounidense. Analiza las diferencias entre las dos civilizaciones y explica el pensamiento de Estados Unidos, pues dicha nación tiene la convicción histórica de que, por destino providencial, debe llevar la democracia y el trabajo al resto del continente. La autora asegura que la linde nacional se mantiene independiente ya que sólo hay influencia pero no hay dominación; más aún, los habitantes de la región constituyen una barrera contra la transculturación.
La división territorial del Segundo Imperio Mexicano, 1865
Authors: Commons Áurea
Published: March 2019

El artículo expone cómo es que las divisiones territoriales han sido establecidas con base en intereses políticos locales y no para fomentar el desarrollo económico, político y social del país. La primera parte es una suma de la administración del Segundo Imperio en la que se promulgaron leyes a favor de los derechos individuales y el sector primario de la economía. La segunda abarca la división territorial que Maximiliano encomendó a Manuel Orozco y Berra y cuyo motivo no sólo fue el relieve geográfico sino también las facilidades de comunicación y avance. Hay una serie de anexos sobre la partición del territorio, así como el decreto del Diario Oficial del Imperiodonde fue plasmada la primera división del México de Maximiliano.
Francisco Bulnes y su visión de las relaciones diplomáticas en la época de Juárez
Authors: Zondowicz Elena
Published: March 2019

Elena Zondowicz analiza la obra de Francisco Bulnes, quien fue definido como un historiador con muchas capacidades pero también con defectos pues, a pesar de su talento como autor, fue un crítico positivista con varios excesos de subjetividad. Zondowicz asegura que Bulnes estudió el México decimonónico con base en la disertación de las relaciones internacionales y que realizó la mayoría de sus escritos sobre Benito Juárez porque lo motivó el desmitificar y presentar a éste como el arquetipo de los defectos de una raza incapaz de alcanzar la democracia.
De los gremios a las sociedades de socorros mutuos: el artesanado mexicano, 1814-1853
Authors: Illades Carlos
Published: March 2019

Carlos Illades intenta reconstruir el largo y complejo proceso a través del cual los artesanos, primero agrupados en gremios, se integraron en sociedades mutualistas, y propone que éstos, efectivamente, lograron constituirse en una clase social. Para ello, analiza el impacto del proyecto industrializador materializado en 1830 sobre la forma de vida del artesanado mexicano, así como sus demandas en contra del capitalismo y la política librecambista
El papel desempeñado por Prim y Manuel Doblado en los preliminares que antecedieron a la intervención francesa
Authors: Villegas Revueltas Silvestre
Published: March 2019

Silvestre Villegas indaga los antecedentes de la invasión francesa y, para ello, estudia las relaciones internacionales de México durante la Guerra de Reforma; particularmente, la actuación de Manuel Doblado, ministro juarista, y Juan Prim, jefe del ejército español. El autor concluye que, de no haber sido por la inteligencia en la negociación de estos dos liberales, la invasión tripartita por parte de Francia, España e Inglaterra, se habría consumado en su totalidad.
Restaurarlo todo en Cristo: Unión de Damas Católicas Mejicanas, 1920-1926
Authors: O´Dogherty Laura
Published: March 2019

Laura O'Dogherty estudia el origen y desarrollo de la Unión de Damas Católicas Mejicanas. Analiza los objetivos que este grupo persiguió mediante obras de caridad y moralización en los estados de la república donde se hizo presente pues consideraban al presidente Obregón como un elemento negativo para la sociedad mexicana. La autora muestra que esta organización, en su lucha por refrendar los valores cristianos, impulsó un proyecto educativo y se opuso a la alternativa socialista como remedio para el problema nacional. Incluye tres cuadros con información sobre los centros y las obras de éstos en el país así como un anexo con los centros regionales y locales.
El pronunciamiento de julio de 1840 en la ciudad de México
Authors: Pérez Toledo Sonia
Published: March 2019

Sonia Pérez Toledo estudia el pronunciamiento federalista encabezado por José Urrea, el cual se oponía al gobierno de Anastasio Bustamante, particularmente al centralismo, a la imposición de contribuciones y a la limitación de la libertad de prensa. Explica que el fracaso del ejército rebelde, formado por emigrantes pobres, se debió a la falta de apoyo en el interior del país y al temor del retorno de Santa Anna.
Reflexionar lo regional
Authors: Serrano Álvarez Pablo
Published: March 2019

Pablo Serrano califica el texto Balance y perspectivas de los estudios regionales en México, compilado por Carlos Martínez Assad, como un acierto ya que, debido a la necesidad de comprobar la heterogeneidad de los procesos históricos, es menester abordar los estudios sociales desde una perspectiva regional y multidisciplinaria. El autor señala que dichas investigaciones se realizarán con base en la historia, la geografía, la cultura y la política con el fin de reformular la metodología que suele homogeneizar las dinámicas colectivas.
Ecosistema de la competitividad caqueteña
Authors: Corredor Jorge Enrique , Giraldo Aguirre Dora Cecilia , Henriquez Cesar Mauricio , Hurtado Hurtado Soraya Lisethe
Published: March 2019

Colombia ha tenido que padecer por más de cincuenta años las consecuencias nefastas de la violen- cia y el conflicto armado. Esto ha traído desplazamiento de la población, tierras baldías en manos de los grupos disidentes, población rural en zona de conflicto, la cual emigró hacia las ciudades capita- les en búsqueda de oportunidades, y apoyo del gobierno como reparador del daño ocasionado a esta población víctima, sin dejar de lado el gran impacto negativo sobre el nivel de competitividad de las economías de los departamentos receptores de dicha población afectada. En el presente artículo se realiza un análisis sobre el impacto que tiene para la economía regional y su nivel de competitividad, el fenómeno de la violencia y el conflicto armado padecido en el país, la llegada de población despla- zada del campo a la cuidad y todo los atropellos que ello implica para sus comunidades.

Mediante un cuadro comparativo se intenta mostrar cómo el conflicto armado sufrido por la región del Caquetá se ha convertido en una barrera para que su economía sea competitiva, en comparación con economías que no han sido tocadas directamente por la violencia y el conflicto armado y que logran ser competitivas.
Análisis de los factores de competitividad: el caso colombiano
Authors: Niño Rodrígez Cladia Rocio , Alonso Contreras Carlos Oswaldo , Caviedes Villegas Clara Sofia , Valbuena Torres Leidy Viviana , Figueredo Carlos Alberto
Published: March 2019

La competitividad en Colombia es un asunto dinámico, de permanente cambio y estudio, desa- fortunadamente se avanza en unos aspectos y el resultado no es el mismo en otros. Por ejemplo, a nivel de gobierno se vienen presentando problemas de corrupción que no paran de asombrar a propios y extraños y son un riesgo para la inversión. Respecto al mercado laboral, tres de cada cinco trabajadores se encuentran en la informalidad; en cuanto a la introducción del país en el mercado mundial, aún es baja a pesar de lo intentado por más de dos décadas; en investigación y desarrollo hay debilidades acentuadas a causa de la calidad de las instituciones y la incidencia del Estado en aspectos como educación y salud. Los problemas de competitividad se acentúan a causa de la trasparencia y eficiencia de las instituciones, sin embargo, no todo parece estar mal: el pilar que encierran los indicadores macroeconómicos es fuerte y da una buena posición a la economía nacional
TGF-β downregulates CAIII expression via MAPK and PI3K signaling pathways in colon carcinoma and osteosarcoma cells
Authors: Aydogan Turkoglu , Okuyan Derya , Kockar Feray
Published: March 2019

Identification of cancer-associated genes is critical for developing effective treatments of colorectal cancer (CRC). A limited number of studies have examined the mechanisms and genes underlying CRC. Abnormal transforming growth factor beta (TGF-?) expression was observed at different stages of carcinoma. We examined the effect of cancer-related cytokine TGF-? on carbonic anhydrase (CA) III gene expression in colon cancer HT-29 cells. TGF-? (500 U/mL) downregulated CAIII gene expression at both the mRNA and protein levels. Transient transfection experiments indicated that different CAIII promoter constructs were active in HT-29 cells. TGF-? reduced transcriptional activity of all promoter constructs, indicating that the potential response element for TGF-?-directed transcription lies within the -108/+86 region of the CAIII promoter. According to the non-Smad pathway inhibitory assay, TGF-? downregulated the CAIII gene through mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and phosphoinositide-3-kinase (PI3K) pathways. The same decreasing effect was determined in the Saos-2, osteosarcoma cell line, indicating that the effect of TGF-? on CAIII was not tissue-specific. However, examination of PI3K and MAPK/ERK signaling pathways with suitable inhibitors revealed that the PI3K but not the MAPK/ERK pathway was responsible for TGF-? downregulation.
Analytical solutions of biharmonic equation by the Fourier-Yang integral transform
Authors: Gao Lin , Zhang Zhizhen , Xing Yan
Published: March 2019

The biharmonic equation are frequently encountered in CFD. In this investigation, the biharmonic equation in the semi-infinite domains is addressed using a new Fourier-like integral transform proposed in [1]. The properties of the new Fourier-like integral transform are expanded in this article. Meanwhile, the analytical solutions for the biharmonic equation in the semi-infinite domains are found. This demonstrates the new Fourier-like integral transform is an efficient and accurate method to clarify mathematical physics problems described by PDE.
Inverse scattering transform for a supersymmetric Korteweg-de Vries equation
Authors: Zhang Sheng , You Caihong
Published: March 2019

In this paper, the inverse scattering transform is extended to a super Korteweg-de Vries equation with an arbitrary variable coefficient by using Kulish and Zeitlin?s approach. As a result, exact solutions of the super Korteweg-de Vries equation are obtained. In the case of reflectionless potentials, the obtained exact solutions are reduced to soliton solutions. More importantly, based on the obtained results, an approach to extending the scattering transform is proposed for the supersymmetric Korteweg-de Vries equation in the 1-D Grassmann algebra. It is shown the the approach can be applied to some other supersymmetric non-linear evolution equations in fluids.
Energy evolution of coal subjected to thermo-gas-mechanical coupling
Authors: Gao Yanan , Gao Feng , Dong Guanghui , Wang Hao , Changa Xueyun
Published: March 2019

In this paper, the orthogonal experiment method is employed to design mechanical test of coal under different temperature, confining pressure, and gas pressure. The results of the experiment were analyzed using statistical methods, such as elastic modulus, peak stress, Poisson?s ratio. The linear model is used to describe the mechanical parameters of coal under the influence of temperature, confining pressure, and gas. The energy formula of coal sample under constant confining pressure is deduced. The evolution of input energy, elastic energy, and dissipation energy in coal deformation process are analyzed.
Roles of adsorption potential and surface free energy on pure CH4 and CO2 adsorption under different temperatures
Authors: Xia Tong-Qiang , Meng Jing-Yu , Wang You-Pai , Kang Jian-Hong , Ren Hong-Yun
Published: March 2019

To fill the knowledge of adsorption characteristics of CH4 and CO2 associated with equilibrium and thermodynamics, adsorption equilibrium tests of pure gas on a coal were conducted under the different temperatures (35 ?C, 50 ?C, and 65?C by the static volumetric method. The equilibrium data were well matched by the SLD-PR model. The influence of some significant factors including temperature, pressure, adsorption potential and surface free energy on gas adsorption capacity were discussed. The results showed that the higher temperature (gas pressure) corresponds to the smaller (larger) adsorption capacity and the larger adsorption potential is, the smaller adsorption capacity is. Taking CH4 as adsorbent, the modified Langmuir equation can well match the SLD-PR model. However, when the adsorption medium is CO2, modified Freundlich equation is better. Using the two modified equations, we study further the relationship among the variation of surface free energy, its reduction rate and gas adsorption capacity. It can be concluded the larger the gas adsorption capacity is, the greater the reduction of surface free energy is, and the smaller the reduction rate of surface free energy is.
Performance on the Rey-Osterrieth complex figure test and the correlation with the magnetic resonance imaging brain lesion volume in multi-infract versus small vessel disease dementia
Authors: Semnic Marija , Semnic Robert , Nikolasevic Zeljka , Bugarski-Ignjatovic Vojislava , Vujanic-Stankov Tijana , Kostic Smiljana , Ocic Gordana , Kozic Dusko
Published: March 2019

Background/Aim. Regarding several cognitive domains, including visuospatial and visuoconstructional abilities, little is known about the differences between vascular dementia (VaD) subtypes, even in the most common sub-types, such as multi-infarct dementia (MID) and subcortical ischemic small vessel disease dementia (SSVD). This paper aimed to identify the differences between the performances on the Rey-Osterrieth Complex Figure (ROCF) test in MID and SSVD and correlate the ROCF scores in both groups with magnetic resonance imaging (MRI) ischemic lesion load. Methods. Sixty VaD patients with matching severity of dementia, age, and education were included in this study: 32 with SSVD and 28 with MID ac-cording to the NINDS-AIREN (National Institute of Neuro-logical Disorders and Stroke and Association Internationale pour la Recherch? et l'Enseignement en Neurosciences) neuroradiological criteria. A quantitative scoring system was performed. ROCF was given to all subjects in three test conditions: copy, immediate recall after 3 minutes, and delayed recall after 45 min. Magnetic resonance imaging (MRI) of the is-chemic brain volumes of anterior and posterior lesions, left and right hemispheric lesions, left and right-sided basal ganglia lesions, and total lesion load (TLL) were calculated in both groups. Results. The MID group was more impaired than SSVD on ROCF copy (p = 0.008), immediate recall (p= 0.005) and delayed recall (p = 0.001). There were significant correlations between ROCF copy score and the TLL (p < 0.05) and posterior brain lesion volume (p< 0.05) in the MID group. Conclusion. The importance of visuospatial, visuoconstructional deficit and impairment of visual memory is disregarded in VaD subtypes. These impairments are more severe in MID than SSVD and the deficit of ROCF copying in MID patients correlates with posterior and total MRI lesion volume.
Accounting and Cybersecurity Risk Management
Authors: Eaton Tim V. , Grenier Jonathan H. , Layman David
Published: March 2019

As the number of cybersecurity incidents continue to rise and stakeholders are becoming increasingly concerned, companies are devoting considerable resources to their cybersecurity risk management efforts and related cybersecurity disclosures. This paper describes how accountants are uniquely positioned to assist companies with these efforts in advisory and assurance capacities. We present a model of effective cybersecurity risk management and discuss how accountants' core competencies can add significant value in each of the model's five stages. In addition, we use several recent high-profile cybersecurity incidents as illustrative examples in each of the five stages. We conclude by discussing implications for accountants.
Генетически кодируемый биосенсор roKate для регистрации редокс-состояния пула глутатиона
Authors: Шохина А. Г. , Белоусов В. В. , Билан Д. С.
Published: March 2019

Генетически кодируемые биосенсоры на основе флуоресцентных белков представляют собой инструмент исследования ряда биологических процессов в живых системах в режиме реального времени. За последние годы было создано целое семейство биосенсоров, позволяющих визуализировать в живых клетках изменения редокс-состояния пула глутатиона. Целью настоящей работы была разработка нового биосенсора для регистрации соотношения 2GSH/GSSG на основе красного флуоресцентного белка mKate2. Для этого методом направленного мутагенеза в структуру флуоресцентного белка вносили пару аминокислотных остатков цистеина, которые при окислении окружающего пула глутатиона формируют дисульфидную связь, что приводит к изменению спектральных характеристик. Полученный биосенсор был протестирован in vitro на выделенном препарате белка, в частности, были исследованы спектральные характеристики, рН-чувствительность белка, окислительно-восстановительный потенциал. Кроме того, биосенсор, названный roKate, был протестирован в культуре живых клеток млекопитающих. Он отличается высокой яркостью и повышенной стабильностью сигнала при изменениях рН в физиологическом диапазоне. От других представителей данного семейства биосенсоров roKate отличается необратимым изменением сигнала при окислении в клетках млекопитающих. Применение данного сенсора предпочтительно в экспериментах с наличием длительного промежутка времени между воздействием на биологическую систему и последующим анализом вызванного эффекта, например в условиях длительной пробоподготовки.
Execution of Security Rights in Islamic Banking at The Religious Court of Purbalingga
Authors: Triana Nita
Published: March 2019

This article examines the execution of a security interest in Islamic banking in the Islamic economic disputes in  the  Purbalingga  Religious  Court. The case of non-performing loans in the world of Islamic banking is often the case, this was due to the debtor defaults. Mortgages used as collateral can be executed based on the decision of the Religious Court. The method used in this research is a kind of field research with the approach of Socio Legal Research, including in the realm of non-doctrinal study. The results show the execution of a security interest in dispute sharia economy in Purbalingga Religious Court has been run in accordance with the mandate of the Act: On the substance of the Implementation of the decision of execution is the end of a case that is the result of what is required by the plaintiff are determined in a court of Religion with using the guidelines do not separate from the disciplinary proceedings contained in HIR or Rbg. On the  Structure  of  Purbalingga Religious Court  carry out executions by institutions that are available from the start to the filing of the petition to the Chairman of the Religious Courts, judges who will examine the final verdict, Executor who will call and will execute and when the auction Clerk role of the mentor  State Property Office and Auction (KPKNL). Culturally law. Purbalingga Religious Court  carry out the execution-based approaches to religion and culture. This approach proved to facilitate execution. Obstacles that faced in general, form, creditors often receive a guaranteed land and buildings where the land certificate is no longer appropriate to the actual situation, the Debtor is not willing to leave the place right dependents, barriers to the sale of objects auction execution which does not go unsold objects auction / auction. Constraints that normally occurs in the execution of this economic security rights dispute, can be resolved by various reinforcement structures / institutions and culture through the law chosen by the Purbalingga Religious Courts.
Upaya Meningkatkan Motivasi Kerja dan Kreativitas dalam Kepemimpinan PAUD
Authors: Munfarijah Siti
Published: March 2019

Lembaga Pendidikan Anak Usia Dini (PAUD) merupakan suatu lembaga yang berupaya untuk menyelenggarakan pembinaan pendidikan yang ditujukan kepada anak sejak usia tiga sampai dengan usia enam tahun yang dilakukan melalui pemberian rangsangan pendidikan untuk membantu pertumbuhan dan perkembangan jasmani dan rohani anak agar memiliki kesiapan dalam memasuki pendidikan lebih lanjut. Untuk mencapai tujuan-tujuan tersebut diperlukan suatu upaya dari seorang pemimpin untuk menjadikan lembaga PAUD menjadi lembaga yang dapat mengembangkan potensi anak usia dini sesuai dengan harapan orangtua dan masyarakat. Kepala sekolah sebagai pemimpin harus dapat melaksanakan fungsi - fungsi manajerial seperti perencanaan, pengorganisasian, pengarahan, pemberian motivasi, pelaksanaan, pengorganisasian, pengendalian, evaluasi dan inovasi.

Kepala Sekolah harus dapat memotivasi guru untuk memiliki kreativitas yang tinggi agar kualitas pembelajaran berhasil dengan baik. Untuk memberikan motivasi,  pemimpin / kepala sekolah dapat melakukan berbagai upaya seperti misalnya : Menciptakan dan mengembangkan suasana organisasi yang merangsang kreativitas, sikap pemimpin yang terbuka seperti kesediaan mendengar , menanggapi, menghargai, dan mempertimbangkan setiap kreativitas dari guru / pendidik. Usaha ini dapat dikembangkan dengan pemberian insentif, reward baik dalam bentuk material maupun non material. Menciptakan dan mengembangkan kerjasama yang dapat menumbuhkan perasaan ikut bertanggungjawab dalam mewujudkan usaha mengembangkan dan memajukan lembaganya, seperti mengadakan MOU dengan organisasi wirausaha atau instansi pemerintah untuk menambah pengetahuan dan kreativitas anak.  

Dalam era globalisasi saat ini, kreativitas merupakan pendukung  kerja yang penting untuk memajukan sebuah lembaga pendidikan khususnya lembaga PAUD, karena kemajuan suatu Lembaga PAUD  sangat tergantung pada sumbangan kreatif yang berupa ide-ide baru dan teknologi baru dari guru maupun masyarakat. Motivasi dan kreativitas dalam kepemimpinan PAUD adalah dua hal yang saling berhubungan dan mempunyai keterkaitan. Tanpa Motivasi kreativitas tidak akan berkembang, karena seringkali kreativitas seorang guru tidak terlihat karena tidak adanya motivasi dari pimpinan. Upaya meningkatkan motivasi dan kreativitas dalam kepemimpinan PAUD sangat diperlukan untuk memajukan suatu lembaga agar lebih berkembang dan berkualitas.
Mining for Reality in Late-Stage Capitalism: Reading Murakami Haruki and Don DeLillo Towards a New Literary Realism
Authors: Chin Gabriel
Published: March 2019

This paper articulates an unexplored convergence between authors Murakami Haruki and Don DeLillo. I contend that these authors share similarities in style, content, and context, particularly in their responses to the epoch Murakami calls late-stage capitalism. Focusing on Murakami’s short story ‘A Folklore for my Generation: a Prehistory of Late Stage Capitalism’ (2007) and DeLillo’s Mao II (1991), I examine each author’s profound concern with the status of literature and representation within this age, arguing that the task of fiction for these two writers is to represent reality in a mode not reducible to the bare fact. I find theoretical support for this reading in the philosophical work of Object-Oriented Ontology (OOO) and draw out from OOO’s philosophical realism the possibility of a new literary realism which not only defends the status of fiction as the genuine possibility of a non-reductive relation to things in the world, but a constructive response to the forces of late-stage capitalism, be they the reductive models of the market, mass-culture, or so-called ‘facts’ themselves. In studying the intersection where these writers cross between Japanese and American contexts within the moment of late-stage capitalism, this essay opens the space for a new understanding of each of their oeuvres more widely and demonstrates the fruitful viability of working in a cross-cultural, cross disciplinary for the possibility of novel, constructive, and imaginative work for the future of literary studies.
“Our old enemy the commodity”: Image, Narration, Spectacular Time
Authors: Barrow Daniel
Published: March 2019

Guy Debord and the Situationist International's analysis of late capitalist temporality remains an under-examined area of their work. Time as a 'form of appearance' - Marx's description of the commodity - replaces the reality of a time that cannot develop quantitatively. This article argues that this far-reaching analysis, which has been controversial in art theory and literary studies, sheds valuable light on theories of narrative time and subjectivity in late capitalist culture.
Software Defect Prediction Using AWEIG+ADACOST Bayesian Algorithm for Handling High Dimensional Data and Class Imbalance Problem
Authors: Suntoro Joko , Christanto Febrian Wahyu , Indriyawati Henny
Published: March 2019

The most important part in software engineering is a software defect prediction. Software defect prediction is defined as a software prediction process from errors, failures, and system errors. Machine learning methods are used by researchers to predict software defects including estimation, association, classification, clustering, and datasets analysis. Datasets of NASA Metrics Data Program (NASA MDP) is one of the metric software that researchers use to predict software defects. NASA MDP datasets contain unbalanced classes and high dimensional data, so they will affect the classification evaluation results to be low. In this research, data with unbalanced classes will be solved by the AdaCost method and high dimensional data will be handled with the Average Weight Information Gain (AWEIG) method, while the classification method that will be used is the Naïve Bayes algorithm. The proposed method is named AWEIG + AdaCost Bayesian. In this experiment, the AWEIG + AdaCost Bayesian algorithm is compared to the Naïve Bayesian algorithm. The results showed the mean of Area Under the Curve (AUC) algorithm AWEIG + AdaCost Bayesian yields better than just a Naïve Bayes algorithm with respectively mean of AUC values are 0.752 and 0.696.