bluuebunny/crossref_metadata_2025 huggingface dataset:
Experiences of the impact of living with COPD and its psychological effects on participating in community-based physical activity in Brazil: a qualitative study. Findings from the Breathe Well group
Authors: Adams Rachel , Martins Sonia , Magalhães Eduardo , Stelmach Rafael , Adab Peymane , Chunhua Chi , Cheng KarKeung , Cooper Brendan G. , de Sousa Jaime Correia , Dickens Andy , Enocson Alexandra , Farley Amanda , Gale Nicola , Jolly Kate , Jordan Rachel , Jowett Sue , Maglakelidze Maka , Maglakelidze Tamaz , Sitch Alice , Stavrikj Katarina , Turner Alice , Williams Siân , Nascimento Vania
Published: November 2023

Physical activity (PA) improves dyspnoea, psychological wellbeing and quality of life (QoL) for people with COPD and reduces their risk of exacerbation. However, engagement in PA is low especially amongst those with anxiety and depression, and provision of PA programmes limited in countries with limited resources such as Brazil. We explored the perceptions of 21 people with COPD about the impact of their disease on taking part in community-based PA programmes in Sao Paulo, Brazil through semi-structured telephone interviews from October 2020 to April 2021. Discussions were audio-recorded, transcribed, and analysed using the Framework method. Five main themes were identified: Knowledge about COPD and its management; Self-perception of life with COPD; Knowledge and experiences about depression and anxiety; Opinions on PA and repercussions of COVID-19. COPD was viewed as a neglected disease that led to a reduction in QoL and is dependent on specialist care. PA was considered to be important in bringing physical and mental health benefits but there were barriers in accessibility of formal PR programmes and therefore local community PA programs were considered to be important. People with mental health conditions tended to view PA more negatively. COVID-19 had reduced PA opportunities, access to COPD treatment and social interaction, and was associated with more exacerbations and emotional suffering. In general, this study showed an urgent need to improve knowledge about COPD and its risk factors and management among both patients, the public and primary healthcare professionals. We provide important content for the formulation of public policies for the implementation of specific activity programs for people with COPD in community spaces using local resources and intersectoral partnerships.
General high-order solitons and breathers with a periodic wave background in the nonlocal Hirota-Maccari equation
Authors: Yang Xiaolin , Zhang Yi , Li Wenjing
Published: November 2023

Soliton and breather solutions to the nonlocal Hirota-Maccari equation with a periodic wave background are constructed via the KP hierarchy reduction approach. By constraining tau functions of bilinear equations in the KP hierarchy, we obtain general 2N-line solitons and Nbreather solutions with a periodic wave background. What needs to be emphasized is the twosoliton can be divided into non-degenerate and degenerate soliton according to the asymptotic analysis. Meanwhile, one- and two-breather solutions in a periodic wave and constant background are investigated.
Present-day mass loss rates are a precursor for West Antarctic Ice Sheet collapse
Authors: Akker Tim van den , Lipscomb William , Leguy Gunter , Bernales Jorjo , Berends Constantijn , de Berg Willem Jan van , de Wal Roderik van
Published: November 2023

The observed mass loss from the West Antarctic Ice Sheet (WAIS) raises concerns about its stability1-4, since a collapse would raise global sea levels by several meters5. This mass loss is projected with ice sheet models that represent the present-day Antarctic ice sheet. We developed a new initialization method that optimizes agreement not only with ice thickness and surface velocity, but also with satellite-observed mass change rates. Starting from this initial state, we project future Antarctic mass changes while holding the ocean and atmospheric forcing constant at present-day values. We find that for a wide range of model settings, Thwaites Glacier and Pine Island Glacier collapse. The collapse is manifested by a slow retreat over several centuries followed by a significant speedup that lasts about 200 years. Our results imply that today’s mass loss rates are a precursor of the deglaciation of large parts of the WAIS, which would raise sea levels by at least a meter in the coming centuries, even without additional climate forcing.
miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s disease
Authors: Han Sang-Won , Pyun Jung-Min , Bice Paula J , Bennett David A. , Saykin Andrew J. , Kim SangYun , Park Young Ho , Nho Kwangsik
Published: November 2023

BackgroundAlzheimer's dementia (AD) pathogenesis involves complex mechanisms, including microRNA (miRNA) dysregulation. Integrative network and machine learning analysis of miRNA can provide insights into AD pathology and prognostic/diagnostic biomarkers.MethodsWe performed co-expression network analysis to identify network modules associated with AD, its neuropathology markers, and cognition using brain tissue miRNA profiles from the Religious Orders Study and Rush Memory and Aging Project (ROS/MAP) (N = 702) as a discovery dataset. We performed association analysis of hub miRNAs with AD, its neuropathology markers, and cognition. After selecting target genes of the hub miRNAs, we performed association analysis of the hub miRNAs with their target genes and then performed pathway-based enrichment analysis. For replication, we performed a consensus miRNA co-expression network analysis using the ROS/MAP dataset and an independent dataset (N = 16) from the Gene Expression Omnibus (GEO). Furthermore, we performed a machine learning approach to assess the performance of hub miRNAs for AD classification.ResultsNetwork analysis identified a glucose metabolism pathway-enriched module (M3) as significantly associated with AD and cognition. Five hub miRNAs (miR-129-5p, miR-433, miR-1260, miR-200a, and miR-221) of M3 had significant associations with AD clinical and/or pathologic traits, with miR129-5p by far the strongest across all phenotypes. Gene-set enrichment analysis of target genes associated with their corresponding hub miRNAs identified significantly enriched biological pathways including ErbB, AMPK, MAPK, and mTOR signaling pathways. Consensus network analysis identified two AD-associated consensus network modules, and two hub miRNAs (miR-129-5p and miR-221). Machine learning analysis showed that the AD classification performance (area under the curve (AUC) = 0.807) of age, sex, andapoEε4 carrier status was significantly improved by 6.3% with inclusion of five AD-associated hub miRNAs.ConclusionsIntegrative network and machine learning analysis identified miRNA signatures, especially miR-129-5p, as associated with AD, its neuropathology markers, and cognition, enhancing our understanding of AD pathogenesis and leading to better performance of AD classification as potential diagnostic/prognostic biomarkers.
Exploring the Chemical Reactivity andBioactivity of Romidepsin: A CDFT-BasedComputational Peptidology Study
Authors: Flores-Holguín Norma , Frau Juan , Glossman-Mitnik Daniel
Published: November 2023

Romidepsin is a cyclic peptide derived from a natural product that has shown remarkable therapeutic potential for the treatment of cancer and other diseases. In this study, we employ a CDFT-based Computational Peptidology methodology to investigate the chemical reactivity and bioactivity properties of Romidepsin. Our approach combines conceptual density functional theory descriptors with cheminformatics tools to estimate the bioactivity scores, and identify the drug-likeness of Romidepsin. Our results provide insights into the potential of Romidepsin as a useful drug candidate for various therapeutic applications beyond cancer treatment.
Evaluating the Transformative Impact of Online Education on Medical Student Learning Outcomes
Authors: Alshammari Hessah , Shaheen Sameerah , Alyahya Khaleel , Mahmoud Shimaa , Al-Rabiah Amal
Published: November 2023

The COVID-19 pandemic forced educational institutions worldwide to shift to online learning as a means of continuing education during lockdowns and social distancing measures. This study investigates the effectiveness of online learning in comparison to traditional on-campus learning, specifically within the context of medical education. Two hundred and three first- and second-year medical students at King Saud University participated in the study. The research employed written exams to evaluate learning outcomes, with a focus on understanding the lecture content. The findings reveal that while online learning initially showed similar learning outcomes to on-campus learning, it resulted in significantly lower outcomes as the lecture progressed. Moreover, a smaller percentage of online students demonstrated a full understanding of the lecture material compared to on-campus students. This study emphasizes the importance of assessing the effectiveness of online learning methods, particularly in medical education, to address students' needs better and improve the quality of online learning systems.
Chemoradiation treatment with or without Concurrent Tumor-Treating Fields (TTFields) in Patients with Newly Diagnosed Glioblastoma (GBM) in China
Authors: Liang Liping , Chen Lingchao , Ni Chunxia , Shi Wenyin , Zhou Zhirui , Chen Shu , Zhu Wenjia , Liu Jiabing , Qiu Xianxin , Lin Wanzun , Zhang Junyan , Qin Zhiyong , Wang Yang
Published: November 2023

Background:The TTFields have received the FDA approval as adjuvant therapy after completing radiotherapy in patients with newly diagnosed glioblastoma (GBM). TTFields and radiotherapy may have synergistic anti-glioma effect based on preclinical study. This study evaluated clinical outcomes of patients with newly diagnosed GBM received concurrent and adjuvant TTFields with chemoradiation or adjuvant TTFields only based on a cohort of patients treated at Huashan Hospital, China.
Methods: This is a retrospective study of patients with newly diagnosed GBM (ndGBM) received TTFields treatment at a single institution from 2020-2021. TTFields treatment was either given adjuvant after chemoradiation alone or concurrent and adjuvant with chemoradiation treatment. Treatment outcome and toxicities were evaluated and compared between the two groups. Overall survival (OS) and progression-free survival (PFS) were evaluated with Kaplan- Meier method. The Cox proportional hazards regression model, data matched by propensity score, and inverse probability of treatment weighting (IPTW) based on propensity score were used to evaluate the effect of TTFields and account for confounding factors.
Results: A total of 72 patients with ndGBM were included in the study; 41 received concurrent and adjuvant TTFields in combination with chemoradiotherapy (concurrent and adjuvant TTFields group, CA-TTF), and 31 received adjuvant TTFields with temozolomide (adjuvant TTFields group, A-TTF). The two groups were well balanced in age, sex, extent of resection, MGMT methylation status, KPS, as well as compliance and duration of TTFields usage. With a median follow up of 17.95 months, there was no significant difference in PFS between CA-TTF and A-TTF groups (14.2 and 15.0 months, respectively, HR: 0.97, p=0.92); or the median OS (20.8 and 20.0 months, respectively, HR: 0.97, p=0.92). After IPTW, there remained no significant differences in PFS or OS. In the STR/biopsy subgroup, the CA-TTF group showed an improving trend in terms of both OS and PFS compared to the A-TTF group, but due to small sample size it is not conclusive.
Conclusions: In this pilot study, no survival difference was detected in ndGBM patients between CA-TTF and A-TTF groups. However, CA-TTF group may have worse prognosis than A-TTF group due to the inclusion of early progression patients. The benefit of concurrent TTF with chemoradiation is currently being tested in a phase 3 trial.
Distinct patterns of postoperative fever in paediatric neurosurgery patients
Authors: Goyal-Honavar Abhijit , Markose Annsmol P , Gupta Ankush , Manesh Abi , Varghese George M. , Rose Winsley , Jonathan Gandham Edmond , Prabhu Krishna , Chacko Ari G.
Published: November 2023

Purpose: Postoperative fever is a common problem following neurosurgery but data on the causes among paediatric patients is sparse. In this report, we determined the incidence, causes and outcomes of postoperative fever in paediatric neurosurgical patients (<18 years), and contrasted the findings with an adult cohort published recently from our unit.
Methods: We recruited 61 patients operated for non-traumatic neurosurgical indications over 12 months. A standard protocol was followed for the evaluation and management of postoperative fever, collecting data regarding operative details, daily maximal temperature, clinical features, and use of surgical drains, urinary catheters, and other adjuncts. Elevated body temperature of >99.9°F or 37.7°C for >48 hours or associated with clinical deterioration or localising features was considered as “fever”; elevated temperature not meeting these criteria were classified as transient elevation in temperature (TET).
Results: Twenty-five patients (34.2%) had postoperative fever, more frequent than in adult patients. TET occurred in 12 patients (16.4%). The most common causes of fever were aseptic meningitis (36%), followed by urinary tract infections (16%), pyogenic meningitis, COVID-19 and wound infections. Postoperative fever was associated with significantly longer duration of hospital admission and was the commonest cause of readmission.
Conclusion: In contrast to adults, early temperature elevations in paediatric patients may portend infectious and serious non-infectious causes of fever, including delayed presentation with aseptic meningitis, a novel association among paediatric patients. Investigation guided by clinical assessment and conservative antibiotic policy in keeping with the institutional microbiological profile provide the most appropriate strategy in managing paediatric postoperative fever.
Wissenschaftsgeleitete Wirkungsreflexion – Ansätze der Qualitätsentwicklung für eine Hochschulbildung der Zukunft
Authors: Ditzel Benjamin
Published: November 2023

Angesichts disruptiver gesellschaftlicher Transformationsprozesse stellt sich für eine „Hochschulbildung der Zukunft“ nicht nur die Frage, wie Prozesse des Lehrens und Lernens zukünftig aussehen werden. Vielmehr stellt sich mit Blick auf die organisationale Rahmung des Lehrens und Lernens auch die Frage, wie eine QM-Praxis in einer komplexen, unsicheren und dynamischen Welt ausgestaltet werden kann. Ausgehend von Bezugspunkten zur QM- sowie zur Organisations- und Managementforschung sowie mit Verweis auf Erfahrungen aus einem Projekt an der HAW Hamburg werden Eckpunkte für eine mögliche Neuausrichtung der QM-Praxis vorgestellt. Reflexion und Forschungsorientierung werden dabei als wesentliche Gestaltungselemente verstanden.
Teaching students to collaborate – insights from interprofessional education development
Authors: Mette Mira , Hinrichs Jutta
Published: November 2023

Since (interdisciplinary) collaboration skills are considered essential to thrive in an unpredictable and uncertain future, higher education is demanded to train students to develop collaboration fluency. However, there are no clear guidelines for effective collaboration skills trainings. Thus, different ideas and reflections on theoretically underpinned pedagogical designs, assessment approaches and the alternating role of teachers (experts vs facilitators) are given and – where possible – illustrated with our experience in developing and implementing interprofessional education. Implications for teachers and higher education institutions are derived.
Planspiele und simulative Methoden in der Lehrkräftebildung – ein Literaturüberblick
Authors: Kadel Julia , Buschmann Christian , Haas Silke , Meßner Maria Theresa , Adl-Amini Katja
Published: November 2023

Die Nutzung von simulativen Methoden in der Lehrkräftebildung ist professionstheoretisch gut begründbar und ihre Wirksamkeit ist vielfach belegt. Bisher unklar bleibt jedoch, welche Art simulativer Methoden in welchen Fächern und Inhalten zum Einsatz kommen. In diesem Beitrag werden auf Basis einer systematischen Literaturrecherche aktuelle Trends und offene Potenziale der Verwendung simulativer Methoden mit einem Fokus auf Planspiele herausgearbeitet. Die Ergebnisse zeigen, dass simulative Methoden zumeist zur Förderung kommunikativer, Diversitäts- oder Klassenführungskompetenzen eingesetzt werden. Planspiele kommen in der Lehrkräftebildung dagegen kaum vor. Implikationen für Lehre und Forschung werden diskutiert.
Perceptions of Malaysian Indian Women on Domestic Violence in Malaysia: A Peek into the Indian Households
Authors:   Faculty of Arts and Social Sciences, Universiti Malaya, Kuala Lumpur, Malaysia, Guna Saigaran Nithiya , Bello Bada Abdulrahman ,   Faculty of Social Sciences, Usmanu Danfodiyo University Sokoto, Nigeria
Published: November 2023

This study investigates how Malaysian Indian women perceived and internalised domestic violence in Malaysia. Domestic violence is linked to gender issues that have disproportionately affected women compared to men in society. In traditional societies, women were frequently socialised to be subordinate to men in terms of roles, responsibilities and positions. These setbacks have contributed to the domestic violence issue among women. Domestic violence is a prime example of exploitation and discrimination against women in various aspects of their lives. Women have typically been passive and resisting domestic violence experiences to protect their household, male partners, children and society. The data for this study were gathered through in-depth interviews with 24 Malaysian Indian women, who were recruited through the purposive sampling technique. The qualitative data was analysed with Nvivo11 software. Three themes were identified that reflect participants’ perceptions of domestic violence in Malaysia. First, participants saw domestic violence as a normalising aspect of marital life. Second, participants saw domestic violence as a serious problem that affects women and their rights. Third, participants saw domestic violence as a sign of male identity to protect women. This study offers gender perspectives, such as the impact of masculinities, the patriarchal system and unequal power relationships in the household. It also explains the complexities of women’s socialisation in traditional households, as well as enlightening various stakeholders in Malaysia on the perceptions of Malaysian Indian women on domestic violence.
Sustainable Tourism Development in Border Regions: A Case Study of Kermanshah Province
Authors: AZARMİ Soolmaz
Published: November 2023

This research uses a case study of Kermanshah province in Iran which has variety of historical, cultural and natural attractions. It is imperative to place emphasis on such attractions in a bid to inform the governments and investors in appropriate planning of tourism so as to achieve the set goals. It is applied research. For this article, we used an analytical and descriptive research methodology. Documental and library research techniques were used to gather data and relevant information for this research. Systematic data collection and information from library and documentary search..Kermanshah also faces several barriers and challenges, including insufficient infrastructure, weak marketing activities, inadequate tourism management, and increasing interest in foreign travel. To capitalize on its vast tourism potential, Kermanshah needs comprehensive planning, infrastructure development, effective marketing strategies, and coordinated tourism management. These efforts are essential to overcome the identified challenges and encourage sustainable tourism in the region. Kermanshah has the potential to position itself as a prominent global sustainable tourism destination, contributing to socio-economic development and cultural exchange.
Protective Effects of Alpha-lipoic Acid, Resveratrol, and Apigenin Against
Oxidative Damages, Histopathological Changes, and Mortality Induced by
Lung Irradiation in Rats
Authors: Seyedpour Nasrin , Motevaseli Elahe , Taeb Shahram , Nowrouzi Azin , Mirzaei Fatemeh , Bahri Mina , Dehghan-Manshadi Hamid Reza , Zhaleh Mohsen , Rashidi Khodabakhsh , Azmoonfar Rasool , Yahyapour Rasoul , Najafi Masoud
Published: November 2023

Aim:

This study investigated the protective effects of three antioxidants on radiationinduced lung injury.

Background:

Oxidative stress is one of the key outcomes of radiotherapy in normal tissues. It can
induce severe injuries in lung tissue, which may lead to pneumonitis and fibrosis. Recently, interest in natural chemicals as possible radioprotectors has increased due to their reduced toxicity,
cheaper price, and other advantages.

Objective:

The present study was undertaken to evaluate the radioprotective effect of Alpha-lipoic
Acid (LA), Resveratrol (RVT), and Apigenin (APG) against histopathological changes and oxidative damage and survival induced by ionizing radiation (IR) in the lung tissues of rats.

Methods:

First, the lung tissue of 50 mature male Wistar rats underwent an 18 Gy gamma irradiation. Next, the rats were sacrificed and transverse sections were obtained from the lung tissues and
stained with hematoxylin and eosin (H and E) and Mason trichrome (MTC) for histopathological
evaluation. Then, the activity of Glutathione peroxidase (GPx), Superoxide Dismutase (SOD), and
Malondialdehyde (MDA) was measured by an ELISA reader at 340, 405, and 550 nm.

Results:

Based on the results of this study, IR led to a remarkable increase in morphological
changes in the lung. However, APG, RVT, and LA could ameliorate the deleterious effects of IR
in lung tissue. IR causes an increase in GPX level, and APG+IR administration causes a decrease
in the level of GPX compared to the control group. Also, the results of this study showed that
RVT has significant effects in reducing MDA levels in the short term. In addition, compared to the
control group, IR and RVT+IR decrease the activity of SOD in the long term in the lung tissues of
rats. Also, the analysis of results showed that weight changes in IR, LA+IR, APG+IR, and control
groups were statistically significant.

Conclusion:

APG and RVT could prevent tissue damage induced by radiation effects in rat lung
tissues. Hence, APG, LA, and RVT could provide a novel preventive action with their potential
antioxidant anti-inflammatory properties, as well as their great safety characteristic.
Comparative Study between the use of Ultrasonic Criteria of Weaning versus the Conventional Criteria of Weaning in Post-traumatic Acute Respiratory Distress Syndrome Patients who were Ventilated for a long Time
Authors: Allam Mohamed Gaber Ibrahim Mostafa
Published: November 2023

Introduction:

Failure to wean and re-ventilation is a major problem in the intensive care unit (ICU). Thirty percent of ventilated patients experience weaning failure and are re-ventilated, especially patients who are ventilated for long durations. Ultrasound provides reliable data on lung parenchyma inflammation resolution and diaphragmatic contraction power, thereby assisting in deciding if the patient should be weaned and consequently reducing the percentage of weaning failure.

Aim of the Work:

To compare the ultrasonic criteria for weaning with the conventional criteria of weaning in patients with post-traumatic acute respiratory distress syndrome (ARDS) who were ventilated for a long time and assess their effect on the ICU stay duration.

Materials and Methods:

This was a prospective, double-blind study performed on 200 participants who were weaned from the ventilator after being ventilated for > 1 week due to respiratory failure. Respiratory failure in the patients was either due to severe lung contusion or post-traumatic ARDS. The patients were randomly and equally allocated in two groups of 100 patients each. Groups A and B comprised patients who were weaned from the ventilator using the conventional and ultrasound weaning criteria, respectively. All patients weaned from both groups were followed up for 6 days for signs of weaning failure and post-extubation respiratory failure. The number of patients who were re-ventilated and discharged from the ICU was recorded and compared in both groups.

Results:

Group A had a significantly higher number of patients who experienced deterioration in consciousness, tachypnea, desaturation, tachycardia, and hypertension in addition to showing chest X-ray infiltration and being re-ventilated than group B. Moreover, group A patients had a significantly longer ICU duration than group B patients.

Conclusion:

The use of the ultrasonic criteria for weaning reduces re-intubation, re-ventilation, and post-extubation respiratory failure. Additionally, its use also decreases the ICU stay in patients with post-traumatic ARDS who were ventilated for a long time.
Effect of the New Italian Legislative Measures on the Eye Lens Protection of Radioexposed Workers
Authors: Ferrari Cristiana , Paolino Agostino , Vischetti Andrea , Spina Alessia , Magrini Andrea , Coppeta Luca
Published: November 2023

Introduction:

Legislative Decree no. 101, published on 31 July 2020 in the Italian Official Gazette, the official journal of the Italian Government, sets out the provisions of Directive 2013/59/Euratom, which establishes the basic safety rules for protection against the risks arising from occupational exposure to ionizing radiation.

Methods:

The main purpose of the legislator was to improve the safety of workers exposed to radiation, updating the previous laws adopted by the Italian government 25 years earlier. Many strategies have been attempted in the past to increase the level of protection of these categories of workers. Still, it is too early to evaluate the effectiveness of the proposed measures.

Results:

Medical professionals play a leading role among other figures involved in the field of occupational radiation protection. To achieve a reliable and detailed evaluation of the risk assessment, which in Italy must be reported in a specific mandatory report called the “Risk Assessment Document”, the legislator has assigned differentiated but coordinated tasks to all the actors involved with different responsibilities in radiation protection.

Conclusion:

The drastic reduction of the dose limits for the crystalline lens is a tool for more effective protection of workers against exposure to ionizing radiation.
A Study on the Life and the Academic Characteristics of Chun-am So Eung-cheon
Authors:   The Association of DaeDong-Hanmun, Oh Bo-ra
Published: November 2023

This paper examined So Eung-cheon's life, associates, and academic characteristics. So Eung-cheon was a scholar in a rural area, unknown to academia, but he had a reputation in the Samnam area of the time and also interacted with Soron scholars and Yeongnam scholars. So Eung-cheon is a remarkable figure in examining academic trends in the Samnam region in the 18th century.
So Eung-cheon was associated with unknown scholars, Yeongnam scholars, and Soron scholars in a countyside, and what is particularly noteworthy in his relationship with Soron scholars. When he was young, So Eung-cheon studied various fields, including all classes of philosophers, Buddhism, Taoism, astronomy, and geography. However, when So Eung-cheon interacted with Soron scholars in his late teens and early 20s, he realized that his past academic direction was wrong and devoted himself to Confucianism.
Yoon Dong-soo and Yoon Dong-won, whom So Eung-cheon served as teachers, played a pivotal role in the establishment of the academic background of the Pa-pyeong Yoon family, which led from Yoon Jeung. They pointed out the problem of So Eung-cheon working on general studies and pursuing a high-altitude discourse, and asked So Eung-cheon to work on practicing ethical norms in everyday life. In other words, Yoon Dong-won and Yoon Dong-soo passed on the academic style of Mushil(實務) from Yoon Jeung to So Eung-cheon. After meeting them, So Eung- cheon emphasized this point to his friends and juniors, emphasizing practice and study of So-hak(小學) in everyday life. Through So Eungcheon's academic trend, a new phase of the academic style in Honam region in the late Joseon Dynasty can be found. In addition, through the friendship between the So Eungcheon and Pa-pyeong Yoon families, it is possible to confirm how the academic style of the Soron leading from Yun Jeung were passed down.
The position[view, opinion] of scholars in the late Joseon Dynasty on the composition of Gewuzhizhi chapter[格物致知章] : With Dongguae Jo Gyuimyung's  as the main data
Authors:   The Association of DaeDong-Hanmun, Kim minhak
Published: November 2023

Gewuzhizhi chapter is very important in the understanding of the text 『The Great Learning(大學)』. Ju-hee said that the Gewuzhizhi chapter was disappeared, and he created it himself and transferred it to 『The Great Learning(大學)』. Many people questioned that the contents of the Confucian classics were created by individuals. Donggye Jo Gwi-myeong also argues that the Gewuzhizhi chapter did not disappear in the first place, and that the contents can be restored by correcting the mixed order.
This paper is the result of introducing the contents and considering the meaning of , a new material containing Donggye Jo Gwi-myong's arguments. The writings of Jo Gwi-myeong and Lee Heon-kyung, which were used as data in this paper, have not yet been mentioned in academia. Jo Gwi-myeong widely reviewed the previous data and insisted on his new theory. There are not many similar cases in the history of the study of Confucian classics in Joseon dynasty, and the contents are also very original. Donggye's  is a work that coincides with Donggye's original work in terms of sentences, and it is considered to be an important material to be studied and remembered.
Preoperative Frailty Assessed Comprehensively by a Questionnaire Predicts a Poor Survival Following Curative Resection of Gastric Cancer
Authors: TAMURA TATSURO , SAKURAI KATSUNOBU , RYU KAORU , MURATA TOMOKO , MIYAMOTO HIRONARI , NISHI SATOSHI , DEGUCHI SOTA , NAMBARA MIKIO , MIKI YUICHIRO , YOSHII MAMI , TOYOKAWA TAKAHIRO , KUBO NAOSHI , TANAKA HIROAKI , LEE SHIGERU , OHIRA MASAICHI , MAEDA KIYOSHI
Published: November 2023

Background/Aim: The concept of frailty has been attracting attention as a comprehensive indicator of the various effects of aging, but no conclusion has been reached on how to evaluate it. The present study investigated the adverse effect of preoperative frailty on short- and long-term outcomes in patients with gastric cancer using a questionnaire about frailty. Patients and Methods: One hundred and twenty-five patients with pathological stage (p Stage) I/II/III who underwent radical gastrectomy for gastric cancer at the Department of Gastroenterological Surgery, Osaka, Japan from April 2015 to December 2016 were enrolled in this study. The frailty index (FI) was calculated by dividing the total score of 50 questions consisting of 1 point per question by 50. The study used multiple logistic regression analysis with 5-year overall survival (OS) as the endpoint to create a receiver operating characteristic (ROC) curve to determine the cut-off point for the FI. The short- and long-term outcomes of the frail and non-frail groups were then compared, and prognostic factors for OS were examined. Results: Regarding the short-term outcomes, the postoperative complication rates did not differ significantly between the two groups. Regarding the 5-year OS rates of the patients with p Stages II/III, the outcomes in the frail group were significantly poorer than those in the non-frail group. In the multivariate analysis of OS, frailty was independently associated with unfavorable outcomes in patients with p Stages II/III gastric cancer. Conclusion: Frailty evaluation in this study may be useful in predicting long-term prognosis in patients undergoing surgical treatment for advanced gastric cancer.
Reasons for Crown Failures in Primary Teeth: Protocol for a Systematic Review and Meta-Analysis
Authors: Lampl Stephan , Gurunathan Deepa , Krithikadatta Jogikalmat , Mehta Deepak , Moodley Desigar
Published: November 2023

Background

There is a tendency nowadays to restore large defects in primary dentition with pediatric crowns instead of conventional restorations. Thus, understanding the factors contributing to the survival or failure of dental crowns in pediatric dentistry is essential for optimizing treatment outcomes.

Objective

The primary objective of this protocol is to outline the methodological approach for analyzing data from observational studies and randomized controlled trials to investigate reasons for the failure of dental crowns in primary teeth and to compute their survival and failure rates.

Methods

A comprehensive literature review will be performed in electronic databases, including PubMed (MEDLINE), Cochrane, Embase, and Web of Science. As per predefined inclusion criteria, we will include observational studies (prospective clinical studies) and randomized clinical trials that have an English abstract and involve children aged 1-10 years undergoing crown restorations. Two independent reviewers will independently screen all retrieved records and full-text articles and extract data. The study’s methodological quality will be appraised using suitable tools. Assessments of publication bias will be performed using funnel plots. The findings will be described qualitatively for the systematic review. If possible, a meta-analysis will be performed to estimate failure rates by dividing the number of failures by the total exposure time. A Poisson regression model, assuming constant event rates, will be used to compute 3-year and 5-year survival proportions. The Pearson goodness-of-fit statistics will be used to assess the heterogeneity of the model. A P value <.05 will be considered significant. All analyses will be performed using R Statistical software (version 4.1.2; R Core Team).

Results

This systematic review and synthesis aim to assess the survival and failure rates of dental crowns in pediatric dentistry. By following this rigorous methodology, we seek to provide valuable insights into the factors contributing to the success or failure of these restorations. The results of our full review will have implications for pediatric dentists, researchers, and policy makers, helping to improve dental care for children.

Conclusions

This systematic review protocol helps in establishing a thorough approach for reviewing failures in pediatric crowns. By following this methodology, standardization and transparency of the process as well as accountability for the stated methods and outcomes will be ensured. The findings of this review and analysis will provide useful data on the survival of crowns to pediatric dentists and researchers.

Trial Registration

PROSPERO CRD42023442266; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=442266

International Registered Report Identifier (IRRID)

PRR1-10.2196/51505
Evaluating the Impact of an App-Delivered Mindfulness Meditation Program to Reduce Stress and Anxiety During Pregnancy: Pilot Longitudinal Study (Preprint)
Authors: Balsam Donna , Bounds Dawn T , Rahmani Amir M , Nyamathi Adeline
Published: November 2023

BACKGROUND

Stress and anxiety during pregnancy are extremely prevalent and are associated with numerous poor outcomes, among the most serious of which are increased rates of preterm birth and low birth weight infants. Research supports that while in-person mindfulness training is effective in reducing pregnancy stress and anxiety, there are barriers limiting accessibility.

OBJECTIVE

The aim of this paper is to determine if mindfulness meditation training with the Headspace app is effective for stress and anxiety reduction during pregnancy.

METHODS

A longitudinal, single-arm trial was implemented with 20 pregnant women who were instructed to practice meditation via the Headspace app twice per day during the month-long trial. Validated scales were used to measure participant’s levels of stress and anxiety pre- and postintervention. Physiological measures reflective of stress (heart rate variability and sleep) were collected via the Oura Ring.

RESULTS

Statistically significant reductions were found in self-reported levels of stress (P=.005), anxiety (P=.01), and pregnancy anxiety (P<.0001). Hierarchical linear modeling revealed a statistically significant reduction in the physiological data reflective of stress in 1 of 6 heart rate variability metrics, the low-frequency power band, which decreased by 13% (P=.006). A total of 65% of study participants (n=13) reported their sleep improved during the trial, and 95% (n=19) stated that learning mindfulness helped with other aspects of their lives. Participant retention was 100%, with 65% of participants (n=13) completing about two-thirds of the intervention, and 50% of participants (n=10) completing ≥95%.

CONCLUSIONS

This study found evidence to support the Headspace app as an effective intervention to aid in stress and anxiety reduction during pregnancy.
Research on Degree Program Construction Platform Scheme Based on Data Fusion Thinking
Authors: Guo Hairu , Ju Shui , Jia Xiaoyan , He Junyi
Published: November 2023

The article analyzes the existing system for evaluating the construction of degree programs, sorts out the requirements for various work tasks such as application, assessment, evaluation, and inspection, and extracts various data information related to the direction, teachers, students, teaching and research, process, quality, and other aspects of degree program construction. On this basis, a degree program construction platform scheme was designed using data fusion thinking, taking into account all relevant work related to degree program construction, and unifying the management of data related to degree program construction. This has a positive promoting effect on the long-term construction and efficient management of degree programs, and is also a beneficial attempt to modernize the governance system and governance capabilities of the degree programs.
A Study on Effective Implementation of ERP Software in the Company
Authors: P Pragadesh Karan , A Abisheck , M Gokul Kannan , J Krithika
Published: November 2023

Abstract: Enterprise Resource Planning (ERP) software has emerged as a transformative technology for modern businesses, aiming to streamline processes, enhance collaboration, and improve overall operational efficiency. This research paper presents a comprehensive study on the effectiveness of ERP software implementation in various organizational contexts. The primary objective is to analyse the impact of ERP systems on business performance, operational efficiency, and decision-making processes.
The Structural Relationship among Perception of K-MOOC, Teaching Presence and University Life Satisfaction: Multi-group Analysis according to Participation in K-MOOC
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, . . , Han Jin Wook , Jo Hyeyoung
Published: November 2023

Objectives The purpose of this study is to examine the structural relationship among K-MOOC perception, teach-ing presence, and university life satisfaction, and to analyze them according to participation in K-MOOC courses using a multi-group analysis. The analysis was conducted using Pearson's correlation coefficient to examine the relationships between variables, and the trends and normality were assessed.
Methods The subjects of the study are 244 students at Chungcheong-do University who are taking K-MOOC courses by 2022. It was analyzed by the multi-group structural equation and the structural relationship among var-iables using the SPSS 25.0 and AMOS 23.0 programs.
Results These are the main results. First, there was a positive correlation between perception of K-MOOC, teach-ing presence and university life satisfaction. Second, the measurement model was deemed suitable, and teaching presence was found to be a complete mediator in the process of K-MOOC perception affecting university life satisfaction. third, the results of multi-group analysis based on participation in K-MOOC courses showed that ‘teaching presence -> university life satisfaction’ had a stronger influence on students who took K-MOOC courses than those who didn't, proving the partial adjustment effect.
Conclusions The results of this study are meaningful in that they provide basic data to raise awareness of K-MOOC. In addition, we would like to propose a plan to activate K-MOOC, focusing on universities and departments.
The Mediating and moderating Effects of Decision-making Participation on the relationship between Early Childhood Teachers' Educational Beliefs and Job Satisfaction
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Shin Goeun , Shin Keonho
Published: November 2023

Objectives In this study, the mediating and moderating effects of teachers' participation in decision-making were investigated in the relationship between early childhood teachers' educational beliefs and job satisfaction.
Methods To this end, a regression analysis was conducted on 275 infant teachers in Gyeonggi-do on educational beliefs, job satisfaction, and decision-making participation. Regression analysis was performed using the SPSS 25.0 program and verified using MACRO Model 4.
Results Among the educational beliefs, decision-making participation showed a mediating effect in the relation-ship between child-centered educational beliefs and job satisfaction. In contrast, decision-making participation showed a moderating effect in the relationship between teacher-centered educational beliefs and job satisfaction. Depending on the degree of participation of teachers in decision-making, the effect on the relationship between educational beliefs and job satisfaction was different. In the group with a low degree of participation in deci-sion-making, job satisfaction decreased, but in the group with a high degree of participation, the effect of job sat-isfaction increased.
Conclusions In the relationship between early childhood teachers' educational beliefs and job satisfaction, deci-sion-making participation plays a role as a mediator and control. In order to increase the job satisfaction of early childhood teachers, it is important to actively participate in decision-making at institutions.
Academic Persistence Intention and Influencing Factors among Graduate Students in Special Graduate Schools
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Min Hong Gy , Jang Jae Hong
Published: November 2023

Objectives The purpose of this study was to explore academic persistence and its influencing factors among graduate students in special graduate schools.
Methods To achieve this purpose, hierarchical regression analysis was conducted using data from 113 participants affiliated with the special graduate school of K University located in Seoul. Specifically, at the individual level, the study examined the influence of academic self-efficacy and major immersion as psychological variables, and gender, age, and semester as background variables. At the environmental level, factors such as the professorstudent relationship, social support from peers, and the quality of educational services provided by the school were set as influencing factors. The study aimed to investigate how these variables affect the intention for academic persistence.
Results First, academic self-efficacy and major immersion were found to have a consistent influence on the intention for academic persistence among graduate students in special graduate schools. Second, gender and semesters of study did not have a significant impact on the intention for academic persistence among special graduate school students. However, age differences showed a significant influence on the intention for academic persistence. Third, social support from peers had a significant impact on the intention for academic persistence. However, the professor-student interaction and the quality of educational services provided by the school did not have a significant influence.
Conclusions The need for the development of programs and activities that enhance students' self-efficacy and major immersion, and support the formation of relationships with fellow learners, has been identified. Furthermore, recommendations have been proposed to strengthen the determination of graduate students in special graduate schools to persist in their academic pursuits, and to foster academic success and career development.
Language Variation between Counselors and Clients Utilizing Topic Modeling in Counseling Process
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Ha-Seon , Cho Nam-Ok , Lee Yoon-Joo
Published: November 2023

Objectives The aim of this study is to utilize counseling content between counselors and clients during the coun-seling process using topic modeling, extract key themes, and investigate language changes over time.
Methods A single counselor conducted individual counseling sessions with Client A and Client B, each lasting 50 minutes, once a week for a total of 5 sessions. The transcripts of these counseling sessions, including a follow-up session, underwent refinement before undergoing frequency analysis and topic modeling.
Results In the frequency analysis, key keywords in Client A's counseling sessions included ‘thoughts,’ ‘people,’ and ‘emotions,’ while in Client B's counseling sessions, ‘mother,’ ‘child,’ and ‘stories’ predominated. LDA topic modeling revealed that Client A's major topics were ‘thoughts and emotions’ and ‘personal life,’ while topics such as ‘husband and emotions’ and ‘people's emotions’ were extracted for the counselor, each occurring 5 times. For Client B, primary topics included ‘professor's thoughts’ and ‘complimentary stories,’ while for the counselor, top-ics like ‘worrisome stories’ and ‘mother's studies’ were extracted, each occurring 8 times. Additionally, DTM topic modeling results showed that both Client A and B had higher topic appearances at the beginning and end stages of counseling, with lower appearances during the counseling process. In contrast, the counselor had a high topic appearance from the beginning to the end, while in the follow-up session, both the client and the counselor showed lower topic appearances.
Conclusions Through this study, extracting core keywords and topics during the counseling process allowed for the identification of client interests and themes, as well as the analysis of topic changes over time. This in-formation can assist counselors in focusing on the client's primary concerns, thus improving the quality of the counseling process. Furthermore, the use of artificial intelligence analysis techniques such as topic modeling in analyzing the content of individual counseling sessions is significant in presenting language changes between counselors and clients during the counseling process.