bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of the etiology, pathogenesis and epidemiology of renal cell carcinoma in kidney transplant recipients
Authors: Trushkin R. N. , Isaev T. K. , Sokolov A. A.
Published: January 2025

Renal cell carcinoma (RCC) in a kidney transplant is a rare condition as it occurs in the donor kidney of a recipient undergoing immunosuppressive therapy and differs exceptionally from a similar cancer that develops in the native kidney. Given the relative rarity, characteristic specificity of RCC in transplant recipients, and the difficulty in diagnosis and treatment, this type of tumor is less thoroughly studied than the «standard» RCC. However, as more transplants are performed and recipients are being detected with this pathology more frequently, the study of this tumor becomes significantly relevant.
Single-center experience in kidney transplantation: outcomes, conclusions, and perspectives
Authors: Khubutia M. Sh. , Dmitriev I. V. , Balkarov A. G. , Anisimov Yu. A. , Shmarina N. V. , Zagorodnikova N. V. , Borovkova N. V. , Minina M. G. , Lonshakov D. V. , Aleksandrova V. O. , Smirnova V. , Rustambek A. U.
Published: January 2025

Kidney transplantation (KT) remains the best treatment for patients with chronic kidney disease (CKD) stage 4–5. It helps patients live longer, have better quality of life, and undergo improved medical and social rehabilitation. This paper examines the outcomes of KT performed between 2019 and 2023.

Materials and methods. There were 1,106 KTs deceased donor KTs performed between January 1, 2029, and December 31, 2023. The recipients had a median age of 45 (37–54) years, with 664 (60%) males and 442 (40%) females. Donors were mainly males (n = 706, 63.8%), with the median donor age being 50 (43–57) years. Induction immunosuppressive therapy (IST) with monoclonal antibodies was administered to 859 (77.7%) recipients, with polyclonal antibodies to 122 recipients (11%), and induction without antibodies to 125 recipients (11.3%). Triple-drug baseline IST consisted of a combination of calcineurin inhibitors, antimetabolites and glucocorticoids. Tacrolimus was the most often utilized calcineurin inhibitor (n = 961, 86.9%), while cyclosporine was used less often (n = 145, 13.1%). Mycophenolic acid (n = 1041, 94.1%) was used as the second medication in most recipients, while everolimus (n = 54, 4.9%) and azathioprine (n = 11, 1%) were used less often.

Results. Primary initial renal graft function was noted in 714 patients (64.6%) and delayed in 392 recipients (35.4%). Overall incidence of surgical complications was 11.6% (n = 130), and immunological complications 9.9% (n = 109). At hospital discharge, 768 recipients (69.4%) had satisfactory kidney allograft (KAG) function, while 276 recipients (25%) were discharged with graft dysfunction; median serum creatinine and blood urea levels were 158 (120–204) μmol/L and 11 (8–16) mmol/L, respectively. Twenty-six recipients (2.4%) were discharged to continue renal replacement therapy; 28 recipients (2.6%) underwent in-hospital graft nephrectomy. Twelve individuals passed away during the hospitalization phase. The cumulative uncensored in-hospital graft and recipient survival rates were 97.5% (n = 1078) and 98.9% (n = 1094), respectively.

Conclusion. KT is an effective and safe transplant modality for stage 4–5 CKD. Our KT outcomes are consistent with those of reputable transplant centers around the globe.
EFEITOS DA EQUOTERAPIA EM CRIANÇA E ADOLESCENTE COM SÍNDROME DE DOWN
Authors: GRAPIGLIA JULIA BOGONI , SILVA MONIKE DOS SANTOS DA , PERES LIVIA WILLEMANN
Published: January 2025

Introdução: A utilização da terapia com cavalos como recurso terapêutico dentro da fisioterapia tem crescido atualmente, nesse método, o cavalo torna-se um agente promotor de ganhos de ordem física, psicológica e educacional. Esse recurso pode ser utilizado em diferentes patologias, especialmente na síndrome de Down, intervém em aspectos como controle postural, estabilidade e equilíbrio. Objetivo: Essa pesquisa objetivou verificar os efeitos nos aspectos motores da Equoterapia em criança e adolescente com síndrome de Down. Métodos: A pesquisa tem caráter quanti-qualitativos, e a amostra conta com uma criança e um adolescente com Síndrome de Down com cinco e quatorze anos, que estejam de acordo com os termos de inclusão deste estudo. Foi realizado o acompanhamento de uma criança e um adolescente durante um período de dois meses. A avaliação foi quinzenal e consiste em ficha de avaliação, ficha de anamnese e Escala de Desenvolvimento Motor. Resultados: Na avaliação final, os resultados foram positivos, evidenciando melhoria nos quesitos equilíbrio, motricidade global e organização espacial. Conclusão: Há benefícios na qualidade de vida, no bem-estar e no desenvolvimento motor em crianças e adolescentes portadores de Síndrome de Down que praticam equoterapia.
A PRÁTICA DE ATIVIDADES FÍSICAS NO COMBATE À OBESIDADE INFANT
Authors: MIRANDA ANDRÉ LUCAS DOS SANTOS , MEDEIROS LAYSA ESHILLEY MACÊDO DE , GAIA LUANA DA SILVA , COSTA ROSA MARIA ALVES DA , MANESCHY MARIELA DE SANTANA
Published: January 2025

Introdução: A obesidade infantil é uma questão global urgente que requer intervenções eficazes e abrangentes. Objetivo: O objetivo deste estudo foi investigar a importância da prática regular de atividade física no combate à obesidade infantil. Métodos: Para tal, realizou-se uma revisão sistemática da literatura, conduzida por meio de buscas de artigos acadêmicos nas plataformas SciELO e Google Acadêmico. Foram utilizadas as palavras-chave "obesidade infantil", "atividade física", "prevenção" e "tratamento". Como critérios de inclusão, foram aceitos artigos publicados nos últimos 20 anos, relevantes para o estudo da obesidade infantil e atividade física, e estar disponíveis em língua portuguesa ou inglesa. Os artigos que não atendiam a esses critérios foram excluídos da análise. Resultados: Foram selecionados três estudos para compor a amostra desta pesquisa. Os resultados dos artigos revisados destacaram que a atividade física não apenas ajuda na redução do peso corporal, mas também melhora a saúde metabólica, sendo mais eficaz quando combinado com a educação nutricional e a participação ativa de famílias e comunidades. Conclusão: Concluiu-se que a integração da atividade física com iniciativas educacionais e políticas públicas de apoio é vital para enfrentar a obesidade infantil.
EDUCAÇÃO FÍSICA INCLUSIVA
Authors: PEREIRA GUSTAVO REIS DE CARVALHO , GARCIA GLADYS ALVES SILVA , SOUSA CÂNDIDA JOSÉLIA DE , LIMA MARCONI PEREIRA , MOURA RANIESE DE JESUS FERREIRA DE
Published: January 2025

Introdução: A Educação Física Inclusiva tem encontrado muitas barreiras desde sua concepção de fato, em meados de 1990. Diante desse fator, estagiários de Educação Física cada vez mais necessitam de esforços para conseguir incluir alunos com deficiências, a fim de que se efetive a realização de propostas inclusivas. Objetivo: Dessa forma, a presente pesquisa teve como objetivo geral identificar se existem dificuldades entre os estagiários de Educação Física da Universidade Estadual do Piauí do Campus Dra. Josefina Demes em incluir alunos com deficiência em suas aulas. Métodos: Os participantes da pesquisa foram discentes matriculados no bloco VIII do curso de Licenciatura em Educação Física da Universidade Estadual do Piauí, a amostra foi delimitada somente para alunos de Educação Física que tiverem vivência de estágio no âmbito do tema investigado desta. A análise de dados baseou-se na estruturação de Bardin. Resultados: as figuras apresentam relatos dos discentes no quesito dificuldades, bem como estratégias utilizadas para inclusão de alunos com deficiência nas aulas de educação física. Conclusão: foi possível descobrir com os relatos, que existem dificuldades sim em incluir alunos com deficiência em suas aulas de Educação Física e que são diferentes problemas enfrentados, seja uma falta de formação adequada, falta de recursos e apoio, ou barreiras físicas e estruturais.
Relação entre Aptidão Física e Composição Corporal dos Atletas Adolescentes 85	de Voleibol
Authors: JESUS EDUARDA EUGENIA DIAS DE , BERNARDI INGRIDY THAIS DELLA BETTA , BRASILINO FABRICIO FAITARONE , ROSA ALEXANDRE , COSTA ALESSANDRA BEATRIZ HILARIO DA COSTA , MORALES PEDRO JORGE CORTES
Published: January 2025

O estudo teve o objetivo de verificar a relação entre aptidão física e composição corporal de atletas de voleibol, adolescentes entre 15 e 16 anos, da região Joinville, Santa Catarina. A população do estudo foi composta 25 atletas de base da AVOJOI da região de Joinville/SC, sendo todos os jogadores do sexo masculino com idade de 15 e 16 anos. As variáveis de aptidão física foram: 1) Salto Vertical, 2) Salto Horizontal, e 3) Velocidade; e as variáveis de composição corporal, foram: 1) Indice de Massa Corporal (IMC kg/m²) e 2) Percentual de Gordura (%G). As informações analisadas no software R Studio, onde os dados foram comparados utilizando a ANOVA One-Way para verificar diferenças significativas nas variáveis. Os resultados mostraram que o IMC (kg/m²) tem efeito significativo (p=0,011) nos valores de Velocidade (3,55±0,18), revelando diferença significativa entre as classificações “Normal” e Sobrepeso” (p=0,010). Assim como, o %G tem efeito significativo nos valores de Salto Horizontal (p=0,036) e Vertical (p=0,012), revelando diferença significativa entre as classificações “Ótimo” e “Moderadamente Alto” (p<0,05). Salienta-se que a interação entre a idade e as demais variáveis não houve significância. Nesse sentido, reforça-se a importância da aplicação dessas variáveis visando à performance dos atletas de Voleibol. Palavras-chave: Voleibol, Aptidão Física, Composição Corporal, Adolescentes.
THE INFLUENCE OF DIGITAL PLATFORMS
Authors: PEREIRA GABRIELA LUIZ MEIGRE DIAS , BREDA HAYSSON NASCIMENTO NUNES , SOARES MISSIAS SANDRE , FERREIRA WEBER GOMES
Published: January 2025

Instagram influencia a busca pelo corpo ideal e a prática de exercícios, mas também pode causar pressões na imagem corporal. O objetivo desse trabalho foi compreender o papel da rede social Instagram na prática de exercício físico, na imagem corporal e suas implicações. Trata-se de um estudo de revisão bibliográfica de natureza básica e integrativa, que tem como objetivo discorrer sobre a temática em estudo de forma descritiva e obter conclusões a partir da abordagem qualitativa, onde foram selecionados artigos para análise. Os resultados demonstraram que o Instagram influencia a prática de atividade física de várias maneiras. Exposição a corpos saudáveis e influenciadores de fitness motiva a atividade física, mas informações imprecisas podem levar a práticas inadequadas. Além disso, a interação social do Instagram motiva, mas comparações e pressões estéticas podem causar insatisfação corporal, especialmente em mulheres. Portanto, a influência do Instagram na atividade física pode ser positiva ou negativa.
NÍVEIS DE ATIVIDADE FÍSICA E QUALIDADE DE VIDA ENTRE UNIVERSITÁRIOS
Authors: OLIVEIRA II ARIEL CUSTÓDIO DE , SILVA VALÉRIA NAZARÉ DA , COSTA FRANCISCO EDENISVALDO DA , MOURA AYLA DE JESUS , CARVALHO LEANDRO PAIM DA CRUZ , SILVA NÉLIDA AMORIM DA
Published: January 2025

Introdução: Uma melhor qualidade de vida (QV) está fortemente associada a comportamentos saudáveis e a prática regular e sistemática de atividade física é um fator fundamental. Apesar da intensa rotina acadêmica, espera-se que universitários da área da saúde apresentem um considerável nível de atividade física (NAF) e boa QV, devido à melhor compreensão dos benefícios para a promoção e manutenção da saúde. Objetivo: Verificar o NAF e QV de universitários da área de saúde da Universidade Estadual do Piauí (UESPI), comparando entre cursos. Métodos: A amostra foi composta por 40 universitários, de ambos os sexos, matriculados nos cursos de Educação Física (n=20) e Enfermagem (n=20) da UESPI-Picos, com a média de 22,3±4,1 anos. Utilizou-se dois questionários: o International Physical Activity Questionnaire (IPAQ versão curta) para mensurar o NAF e o World Health Organization Quality of Life (WHOQOL-Bref) para avaliar a QV, ambos na versão em português, além de um questionário sociodemográfico. Os dados foram analisados pelo SPSS® versão 25.0. Resultados: Os estudantes do curso de Educação Física apresentaram escore de QV significativamente maior nos domínios físico (p<0,001), psicológico (p=0,004) e meio ambiente (p=0,012), mas não no domínio relações sociais (p=0,096), em comparação com os acadêmicos do curso de Enfermagem. Em relação ao NAF, 20% dos estudantes de Educação Física foram classificados como ativos e 50% muito ativos. Os estudantes do curso de Enfermagem, 35% foram classificados como sedentários, 35% ativos e apenas 5% muito ativos. Conclusão: Embora sejam estudantes de cursos da área da saúde, há ainda um percentual considerável que não atinge o NAF mínimo recomendado pelos órgãos de saúde, em especial no curso de enfermagem.
O PROFESSOR DE EDUCAÇÃO FÍSICA NO AFECTO POSITIVO DOS ALUNOS
Authors: ESQUEDA-VALERIO ERIC IVÁN , VARGAS-BATRES DIANA MAGDALENA , FERNÁNDEZ-ARREDONDO JUAN ULISES , GARCÍA-CASTILLO NAYELI , LÓPEZ-WALLE JEANETTE MAGNOLIA
Published: January 2025

Introdução: A educação física no México enfrenta desafios na motivação e envolvimento dos alunos do ensino secundário. Este estudo tem como objetivo analisar as inter-relações entre a qualidade da apresentação dos trabalhos de casa pelo professor de educação física, a satisfação da necessidade de novidade e o afeto positivo dos alunos do ensino secundário em Aguascalientes, México. Metodologia: A investigação, de carácter correlacional e transversal, envolveu 398 alunos com idades compreendidas entre os 11 e 14 anos. Foram utilizadas análises descritivas, cálculos de fiabilidade e correlações com o SPSS v27, bem como análise fatorial confirmatória e equações estruturais com o AMOS v24. Resultados: Os resultados revelam que, ao testar os modelos, os resultados indicaram que a apresentação da tarefa estava positiva e significativamente associada à satisfação com a novidade, bem como a satisfação com a novidade e o afeto positivo, e quando foi feita uma relação direta entre a apresentação da tarefa e o afeto positivo, esta relação não foi significativa, indicando que havia uma mediação total da satisfação com a novidade. Conclusão: Conclui-se que a qualidade da apresentação da tarefa pelo professor de educação física influencia significativamente a necessidade de satisfação com a novidade por parte dos alunos e está associada ao seu afeto positivo, o que pode ter implicações importantes para a motivação e o empenho dos alunos nas aulas de educação física.
BIOLOGIA CELULAR EM LICENCIATURAS DE EDUCAÇÃO FÍSICA EM INSTITUIÇÕES PÚBLICAS
Authors: OLIVEIRA BRUNO BARROS DE , MEIRELES JOSÉ ROBERTO CARDOSO
Published: January 2025

Introdução: O profissional de Educação Física é múltiplo, atuando inclusive em equipes multidisciplinares de programas de atenção à saúde. Assim, sua formação deve contemplar matérias básicas que lhe permita compreender a fisiologia humana. Dentre estas, a Biologia Celular constituí a base da fisiologia, anatomia e histologia, uma vez que em última análise a saúde depende das células. Objetivo: Analisar, através dos Projetos Políticos Pedagógicos de Cursos (PPPC), a abordagem da Biologia Celular em cursos de Licenciatura em Educação Física de Instituições de Ensino Superior públicas brasileiras.  Métodos: Através de pesquisa qualitativa documental, analisou-se nos PPPC (1) a oferta da disciplina de Biologia Celular e/ou disciplinas que com conteúdos relacionados a Biologia Celular (carga horária total), (2) o período do curso em que a disciplina é indicada, (3) natureza (obrigatória ou optativa), (4) a metodologia (prática e/ou teórica e/ou extensão com respectiva carga horária) e (5) os conteúdos abordados. Resultados: De 59 PPPC analisados observou-se que a disciplina de Biologia Celular é oferecida em apenas seis dos cursos (cerca de apenas 10 %). Neste a matéria tem carga horária muito variada (de 30 h a 97 75 h) e conteúdos extensos que na maioria não está de acordo com a carga horária. Conclusão: É preciso uma revisão nos currículos para a inserção do estudo da célula, uma vez que esta estrutura é a base dos tecidos, órgãos e sistemas do corpo humano. Isto contribuiria para uma formação mais sólida dos educadores físicos para atuar na área da saúde.
Influence of chemical composition of steels for production of grinding balls on their deformation characteristics
Authors: Umanskii A. A. , Baidin V. V. , Simachev A. S.
Published: January 2025

The conducted studies determined the patterns of influence of chemical composition and deformation parameters of ball steels with experimental chemical composition on their deformability. The development of experimental chemical compositions of ball steels was carried out based on the existing experience of domestic and foreign researchers, taking into account the possibility of further application of the obtained results for ball steels of standard grades. The studies were carried out using a specialized laboratory installation by the method of hot-rolling samples. An increase in the carbon content in the range of 0.72 ‒ 0.85 %, manganese in the range from 0.72 to 0.85 %, chromium in the range of 0.38 – 1.71 % and nickel in the range from 0.08 to 0.87 % has a significant effect on increasing the deformation resistance of steels. At the same time, the quantitative effect of carbon content in the steels on their deformation resistance is much more pronounced in relation to manganese, chromium and nickel. It was determined that a decrease in the deformation temperature from 1200 to 900 °C, an increase in the deformation rate in the range from 1 to 10 s–1 and true deformation in the range 0.05 ‒ 0.35 cause an increase in the deformation resistance of ball steels, regardless of their chemical composition. The influence of all these parameters on the deformation resistance of steels has a pronounced nonlinear character and the deformation temperature has the greatest relative influence on the deformation resistance. The data obtained are summarized in the form of a multiple regression equation, which establishes the quantitative relationship between the resistance of steel to deformation with its chemical composition and deformation para­meters. Verification of the adequacy of the obtained equation in relation to the rolling conditions of ball steel billets of standard grades at the continuous medium-grade mill 450 of JSC EVRAZ United West Siberian Metallurgical Plant confirmed the possibility of using it to predict the energy-power parameters of rolling ball steels of various chemical composition.
Functional properties of plastic deformation resistance of 12Kh18N10T steel
Authors: Vydrin A. V. , Krasikov A. V. , Korsakov A. A. , Geim E. A.
Published: January 2025

The resistance of metals and alloys to plastic deformation has functional properties, since it depends on the history of the development of deformation over time. This is especially true for hot deformation processes. At the same time, complexity of the mathematical description and lack of the necessary experimental equipment for a long time did not allow us to design functionals of this type. Currently, due to the emergence of multifunctional research complexes like Gleeble, such an opportunity has appeared. Accordingly, a methodology was developed to study the functional properties of the resistance of metals and alloys of plastic deformation, which was applied to the study of 12Kh18N10T steel. The choice of steel grade is due to the fact that the behavior of austenitic stainless steel during plastic deformation differs significantly from carbon steels. On the other hand, at present, more and more attention is being paid to the production of metal products from stainless steels. This is due, on the one hand, to the tighte­ning of the operating conditions of metal products, the development of new areas of their application and, on the other hand, a fairly high share of imports in the market of products made of austenitic stainless steels. Therefore, the study of the technological properties of such metals and alloys is relevant. At the same time, it should be noted that the most significant functional properties of the metal resistance to plastic deformation are manifested during hot deformation under continuous rolling conditions. Therefore, in this paper, the temperature range of hot plastic deformation is investigated. The results obtained can be used to determine the energy-power parameters in such processes as continuous rolling of strips in the finishing groups of strands and continuous rolling of sleeves in the lines of modern pipe rolling units.
Effect of mechanical processing on reduction of iron oxides in man-made raw materials
Authors: Kleonovskii M. V. , Sheshukov O. Yu. , Mikheenkov M. A. , Mikheenkov A. M. , Matyukhin O. V.
Published: January 2025

The study considers ways to increase the efficiency of reduction of iron oxides from man-made waste (dust from electric arc furnaces) using mechanochemical activation (MCA), grinding and pressing. The analysis of chemical and phase compositions of the dust samples was carried out, which made it possible to identify their potential for processing. The experiments included a study of the effect of grinding and pressing at pressures up to 300 MPa on the materials’ phase composition, as well as an assessment of the effects of coke addition during MCA. To study the effect of pressing pressure on the reduction processes, briquettes were fired at a temperature of 1200 °C. The results showed that the degree of iron metallization increases with an increase in pressing pressure: concentration of metallic iron reaches 19 % at a pressure of 300 MPa, which is higher compared to 17 % in the initial state without pressing. The novelty of the work lies in optimizing the pressing parameters and demonstrating its effect on the iron reduction process. The proposed conditions make it possible to increase the efficiency of processing man-made waste, which can be used to improve the environmental and economic components of production.
Three peculiar new genera of lebiine carabid beetles from Queensland, Australia (Insecta: Coleoptera: Carabidae: Lebiini)
Authors:   Queensland Museum, Baehr Martin
Published: January 2025

Three new genera and four species of the carabid tribe Lebiini are described from eastern Queensland, Australia: Anomotariella gen. nov. with the species A. hippocrepis sp. nov.; Geoffreyella gen. nov. with the species G. holoserica sp. nov. and G. lamingtonensis sp. nov.; and Australovelinda gen. nov. with the species A. seriata sp. nov. The wide, explanate mandibles, presence of a wide mental tooth, denticulate tarsal claws, slightly widened labial palpi, and the narrow, elongate, and parallel-sided gonocoxite 2 place Anomotariella in the subtribe Anomotarina (=Calleidina), but in body shape and in the setosity of the female gonocoxite 2 it is quite distinct from all described Oriental-Australian genera of the subtribe. The structure of the ligula, the female gonocoxite 2, and the male aedeagus place the genus Geoffreyella in the lebiine subtribe Dromiina, but it is very peculiar within this group because of the atypical, dense, depressed pilosity on the whole body. The setosity of the female gonocoxite 2 is also unusual within the subtribe, although its shape is dromiine-like. Although the female genitalia of Australovelinda are not yet known, the body shape, structure of the mouth parts, and structure of the dorsal surface demonstrate that this genus belongs to the small tribe Lichnasthenina which has not previously been recorded from Australia and was known from only southern Africa, Madagascar and India. Their peculiar body shapes and colour patterns make all the new genera easily identified among the Australian lebiines. Anomotariella and Geoffreyella apparently do not possess close relatives within their respective subtribes.
Permissive strategies in intensive care units (ICUs): actual trends?
Authors: Domi Rudin , Coniglione Filadelfo , Huti Gentian , Lilaj Krenar
Published: January 2025

Permissive strategies in the intensive care unit (PSICU) intentionally allow certain physiological parameters to deviate from traditionally strict control limits to mitigate the risks associated with overly aggressive interventions. These strategies have emerged in response to evidence that rigid adherence to normal physiological ranges may cause harm to critically ill patients, leading to iatrogenic complications or exacerbation of underlying conditions. This review discusses several permissive strategies, including those related to hypotension, hypercapnia, hypoxemia, and lower urinary output thresholds. The key principles of these strategies require careful balancing and close monitoring to ensure that the benefits outweigh the risks for each patient. This approach emphasizes individualized care, thoughtful decision-making, and flexible application of guidelines. The use of a PSICU may help minimize the side effects of treatment while addressing the primary condition of the patient and allowing for a more holistic view of critically ill patients.
PUMPING UNIT PRESSURE OBSERVER WITH ASYNCHRONOUS ELECTRIC DRIVE
Authors:   Omsk State Technical University, Lysenko Oleg A.
Published: January 2025

Relevance The synthesis of a liquid pressure observer for a pumping unit with an asynchronous electric drive is considered. This type of electric drives with a centrifugal pump is widely used in agriculture and housing and communal services, industry, and transport, which indicates its relevance. This electrical engineering complex includes a source of electric energy, an electric motor, a pump as an executive body and a technological object. The use of closed feedback in adjustable electric drives of pumping units for monitoring liquid pressure leads to the need to determine this coordinate. This task can be accomplished by using indirect pressure estimates using the Luenberger observer, based on information obtained from current and voltage sensors of the asynchronous electric drive. Aim of research The main aim of the research perform a synthesis of a pressure observer for a pumping unit with an asynchronous electric drive. Research methods The Luenberger observer was used to identify the pressure. The performance of the synthesized observer was tested using simulation models of the electric drive and the observer in the Simintech environment. Results A pressure observer for the electric drive of a pumping unit has been developed. A simulation model of the electric drive of a pumping unit and a pressure observer has been developed in the Simintech environment, allowing the pump output coordinates to be estimated in transient modes. A comparison has been made of the estimated pressure value obtained using the synthesized observer with the transient process curves of the reference pressure, with changes in the value and frequency of the stator voltage, as well as the hydraulic resistance of the pressure pipeline. As a result of the work performed, it has become possible to determine the pump pressure based on the values of the stator current and voltage in dynamics.
SOFTWARE AND TECHNICAL IMPLEMENTATION OF THE INFORMATION MEASURING AND CONTROL SYSTEM OF THE ACETYLENE HYDROGENATION PROCESS
Authors:   Ufa State Petroleum Technological University (Branch in Salavat), Bashirov Mussa G. , Kryshko Konstantin A. ,   Ufa State Petroleum Technological University (Branch in Salavat), Khafizov Alik M. ,   Ufa State Petroleum Technological University (Branch in Salavat)
Published: January 2025

Relevance The development of an information measuring and control system for ethylene production in Russia is of key importance for ensuring the efficiency, safety and competitiveness of the chemical industry. Ethylene is a basic product of the petrochemical industry, and many products are made from it, including plastics, synthetic rubbers and chemical fibers. That is why the optimization of this production directly affects the economy and technological development of the petrochemical industry. In the era of information technology, it is important to develop not only technological aspects in the petrochemical industry, but also to pay attention to the development of information and measurement systems for process control. One of the aspects of improving the information and measurement and control system of the facility is software and technical modernization. Aim of research Increasing acetylene conversion by improving the information and measurement system for controlling the acetylene hydrogenation process. Research methods In the course of the research, an analysis of scientific and technical literature devoted to software and technical aspects of the development of information measuring and control systems for petrochemical processes was carried out. Methods of statistical analysis of process parameter data were used, as well as modern approaches to software development, including programming with functional blocks and the use of specialized modeling tools. Results Software has been developed for an information-measuring and control system for acetylene hydrogenation using virtual analyzers and archived data from an active acetylene hydrogenation reactor.
Metabolic Reprogramming in Prostate Cancer: The Roles of HOXB13 and FASN in Tumor Progression and Therapy
Authors: Saeed Faisal , Harik Lara
Published: January 2025

Metabolic reprogramming, particularly lipid metabolism, is a hallmark of cancer progression and a critical vulnerability in prostate cancer (PCa). Two pivotal studies, one by Lu et al. and the other by Dairo et al., have illuminated the roles of HOXB13, a transcriptional regulator, and fatty acid synthase (FASN), a key enzyme in lipid biosynthesis, in the metabolic dysregulation of PCa. The Lu et al. study highlights HOXB13’s role in androgen receptor (AR)-independent PCa, where it regulates lipid metabolism via epigenetic mechanisms involving histone deacetylase HDAC3. A G84E mutation in HOXB13 disrupts this regulation, leading to increased lipid synthesis and a pro-metastatic phenotype. The Dairo et al. study demonstrates that FASN hypomethylation, coupled with increased expression, drives lipid biosynthesis critical for tumor growth. Both studies establish a link between HOXB13 mutations and FASN dysregulation, underscoring their interplay in PCa biology. Therapeutically, pharmacological inhibition of FASN mitigates the aggressive features of HOXB13-deficient or mutant PCa, highlighting lipid metabolism as a promising target. Despite their strengths, including robust methodologies, limitations include reliance on preclinical models and the need for broader patient diversity. These studies collectively emphasize the potential of metabolic and epigenetic interventions for precision medicine in PCa, paving the way for novel therapies targeting lipid metabolism in patients with specific genetic and epigenetic profiles.
cDNA generation (RT) using RevertAid reverse transcriptase v1
Authors: Valle-Garcia David
Published: January 2025

This protocol is used for generating cDNA from purified RNA. It is based on RevertAid's manufacturer's protocol, with minor modifications. It can be used with other common RT enzymes such as M-MVL, just make sure to incubate the enzyme at the right temperature. Using this protocol, we have successfully generated cDNA from eukaryotic RNA from several sources. The cDNA can be further used for qPCR, clonning, end-point PCR, etc.
ОКЕАН ЭНЕРГИИ СО ДНА ОКЕАНА
Authors: Коробко А.Н.
Published: January 2025

Электроэнергия всё больше становится самым востребованным энергетическим ресурсом в мире, её дефицит всё больше обостряется с вводом в эксплуатацию каждого нового потребителя. Энергетическая бедность – это новая реальность в 21 веке, с которой уже столкнулась половина человечества. Особенно остро ситуация обстоит в Европе, Англии, Японии, США и Китае. Но, как мы видим, последствия той зимы таковы, что ситуация с энергетическим кризисом только усугубляется. Несмотря на рекордный ввод в 2020 году установленных мощностей солнечной (126 ГВт) и ветровой (112 ГВт) энергетики, их общая выработка упала на 12% из-за особенностей установившейся погоды. Ставка на альтернативные источники энергии в глобальном энергопереходе провалилась. Например, Германия, которая является лидером по использованию солнечно-ветровой энергетики (доля в 2020 году – 32,1%), является также лидером по стоимости электроэнергии для домохозяйств и лидером по неустойчивости энергосистемы, о чём уже в открытую предупреждает Стефан Капферер - глава крупного оператора систем передачи электроэнергии Германии «50Hertz». "Нам нужны электростанции, которые мы можем регулировать в долгосрочной перспективе, чтобы гарантировать надёжность поставок электроэнергии в Германии" - заявил Стефан Капферер в ответ на угрозу электроэнергии вывода последних угольных и атомных станций из энергосистемы страны и замену их на ветрсолнечную генерацию. В этой статье будут рассмотрены основные способы преобразования энергии океанов в электрическую энергию.
Разработка тематических моделей корпуса по корпусной лингвистике с автоматическим назначением меток тем
Authors: Митрофанова Ольга Александровна , Голубев Ростислав Васильевич , Гусяцкая Полина Андреевна , Макеев Кирилл Владимирович , Плюснина Елизавета Алексеевна , Сухан Даниил Дмитриевич , Трошина Александра Валерьевна , Уткина Александра Алексеевна
Published: January 2025

В статье представлены результаты экспериментов по обучению семейства тематических моделей корпуса текстов по корпусной лингвистике, создаваемого на кафедре математической лингвистики СПбГУ под руководством В. П. Захарова. Тематическое моделирование корпуса ТКиКЛ осуществлено с помощью алгоритмов NMF, LSA, LDA, Biterm. Обобщение тем с помощью меток реализовано на основе обработки данных из выдачи информационно-поисковой системы, статических предсказывающих моделей Word2Vec, обученных на корпусе, а также большой языковой модели ChatGPT. Результаты тематического моделирования с назначением меток тем сопоставляются с данными о распределении докладов по тематическим блокам конференций в соответствии со схемой экспертной разметки.
Электронное взаимодействие общественных активистов и власти: возможности и проблемы на примере кампаний «Антиборщевик» и «Спаси Горенский лес»
Authors: Попова Мария Юрьевна
Published: January 2025

В последние годы онлайн-взаимодействие стало нормой не только для граждан, но и для госструктур, и всё больше людей предпочитают обращаться к представителям власти в электронном виде. Накоплено достаточно много материала по такому взаимодействию и настала пора его проанализировать для повышения эффективности, как с точки зрения граждан, так и государственных органов. На основе опыта двух общественных кампаний, в рамках которых граждане продвигали свои природоохранные интересы, методом включённого наблюдения были выявлены основные проблемы коммуникации общества и власти, а также предложены способы их решения. Вариантов электронного взаимодействия общественных активистов с представителями власти достаточно много, но суть проблем везде схожая. Она кроется не в электронных сервисах, а в самих процессах, которые эти сервисы автоматизируют. По ходу исследования удалось увидеть, что можно изменить во взаимодействии общества и власти для взаимопонимания и скорейшего решения проблем.
Цели и факторы институциональных трансформаций системы электронного гражданского участия в России: данные экспертных интервью
Authors: Панфилов Георгий Олегович
Published: January 2025

В настоящей статье представлены результаты исследования коллектива Центра технологий электронного правительства Института дизайна и урбанистики Университета ИТМО (ЦТЭП) с применением метода экспертных интервью, посвященного институциональным трансформациям системы электронного гражданского участия в России, произошедшим в результате централизации политики цифрового развития. Были собраны и проанализированы данные от 76 экспертов из 33 регионов России, являющихся непосредственными участниками построения и эксплуатации системы электронного гражданского участия (руководители органов власти и местного самоуправления, общественные активисты, разработчики и исследователи). В результате анализа полученных данных были сформированы две целевые модели, отображающие цели региональных и федеральных органов власти при реализации проектов электронного гражданского участия, и факторная модель, отображающая ключевые факторы, влияющие на трансформации институтов электронного участия в регионах. Основной вывод, сформированный в результате исследования — институциональные трансформации обусловлены значительным количеством разных факторов: от политических и управленческих, до экономических и объективных, а происходящие изменения — продукт столкновения разных целей и интересов ключевых стейкхолдеров государственной политики.
Исследование использования цифровых сервисов муниципальными служащими Санкт-Петербурга
Authors: Метелева Алина Сергеевна , Филатова Ольга Георгиевна , Слав Юлия    Эдуардовна , Чугунов Андрей Владимирович
Published: January 2025

В статье представлены результаты социологического опроса муниципальных служащих Санкт-Петербурга об отношении к городским цифровым сервисам. Опрос позволил определить степень осведомлённости респондентов о существующих сервисах, охарактеризовать особенности использования сервисов в работе органов местного самоуправления (ОМСУ) и выявить потребность в создании отдельных цифровых сервисов для муниципальных служащих Санкт-Петербурга. По результатам пилотного исследования сделаны выводы о недостаточно эффективном использовании цифровых сервисов сотрудниками ОМСУ непосредственно для взаимодействия с жителями муниципалитетов, необходимости повышения цифровой грамотности муниципальных служащих и недостатках системы межуровневого взаимодействия ведомств и структур. Предложены направления экспертной и исследовательской активности для развития муниципального сегмента Санкт-Петербурга.
Внедрение чат-ботов в деятельность органов местного самоуправления Санкт-Петербурга
Authors: Вильнер Ирина Александровна
Published: January 2025

В статье рассматриваются возможности цифровизации муниципального управления с акцентом на применении диалоговых агентов (чат-ботов). Представляются предварительные результаты проекта «Цифровая экосистема муниципалитета», основанного на применении чат-ботов и реализуемого во внутригородском Муниципальном образовании Санкт-Петербурга Муниципального округа УРИЦК. Анализ специфики применения цифровых технологий, обеспечивающих автоматизацию взаимодействия с гражданами, позволяет сформулировать рекомендации по масштабированию данного проекта на другие муниципальные образования города. Внедрение муниципальных чат-ботов в Санкт-Петербурге поможет сделать работу органов местного самоуправления более открытой и проактивной, оптимизировать и автоматизировать обработку входящих запросов от граждан, повысить удовлетворенность граждан от взаимодействия с органами местного самоуправления, экономить ресурсы муниципальных образований для направления их на решение иных важных задач, сократить число процедур с привлечением человеческих ресурсов, сократить текущие расходы на содержание аппаратов органов публичной власти.
Проблемы описания объектов цифрового наследия
Authors: Прокудин Дмитрий Евгеньевич
Published: January 2025

В современном обществе осознаны и решаются проблемы сохранения цифрового наследия как части культурного наследия. Существуют различные инициативы, в рамках которых оцифровываются объекты культурного наследия (вторичное цифровое наследие). Исторически этими видами деятельности занимаются институции культуры — библиотеки, архивы и музеи. В этих сообществах сложились подходы и стандарты описания объектов культурного наследия. Эти же подходы используются и для описания оцифрованных объектов. В рамках деятельности разработчиков программного обеспечения и информационных систем, коллективов по выполнению цифровых гуманитарных проектов, инициативных групп появляются различные цифровые объекты, претендующие стать в будущем первичным цифровым наследием. Для некоторых из них разрабатываются стандарты описания. В целом, задачи описания и классификации цифровых объектов являются одной из важнейших в деятельности по сохранению цифрового наследия. В данном исследовании анализируются существующие подходы к описанию и классификации различных цифровых объектов. Отдельное внимание уделяется описанию и классификации информационных систем как сложных программно-аппаратных комплексов. На основе анализа выявляются проблемы, не позволяющие предложить единый подход к описанию различных объектов цифрового наследия. Предлагаются пути решения проблем, что направлено на возможность систематизации и каталогизации цифрового наследия, что позволит синхронизировать и интегрировать деятельность заинтересованных сторон в области сохранения цифрового наследия.
A NEW DIMENSION IN SOMALI-TURKEY RELATIONS: WHY SOMALIA SEES TURKEY AS A SECURITY PARTNER?
Authors:   University of Wroclaw, Taşkın Murat Özay , Şenyurt Sümer Esin ,   University of Silesia
Published: January 2025

Sub-Saharan Africa is one of the regions characterized by civil wars, terrorism and instability. This situation has required countries in this geography to identify strategies and take various measures to protect themselves from risks and threats. Security and stability in the region are of great importance for the Somali state, which is located in the Horn of Africa and in today's conjuncture, both fighting against terrorist organizations such as Al-Shabaab, which continue to exist in the region, and trying to counter piracy activities on its coasts opening to the Red Sea and the Indian Ocean. In this context, Somalia has chosen Turkey, with which it has positively deepened its relations, as its strategic security partner among many dominant actors in the region against potential risks in the region and has given Turkey an effective mission for the security and stability of its coasts with the new 'Defense and Economic Cooperation Framework Agreement' signed in February 2024. At this point, this article will mainly focus on why Somalia, grappling with security challenges in the Horn of Africa, has embraced and favoured Turkey as a strategic partner and ally, and will also examine the putative relationship dynamics that led to the signing of a new agreement. By addressing these dynamics from a historical perspective and analyzing Somalia's security needs, this study will also examine the dynamics behind Turkey's important role in Somalia and try to analyze the dynamics behind Turkey's important role in Somalia's coastline in line with the question of why Somalia sees Turkey as a security partner.
The Federal subject as a basic element of the geolegal sustainability of Russia
Authors: Tarasov A. D.
Published: January 2025

The article raises the question of the exceptional importance of the territorial organization of the state. The author proceeds the fact that geolaw is designed to identify specific features that have a positive or negative impact on the spatial development of the country. The article reveals the characteristic features of Russian federalism that exist in the conditions of the historically established geo-legal policy of state authorities aimed at establishing an effective strategy for the holistic and sustainable development of regions. The author analyzes the legal basis of the existing system of Russian territorial development, including by the example of strategic planning documents. The article emphasizes the importance of such a category as geolegal sustainability, defines it, and provides examples of threat to them. The federal subjects, as structural elements of the national architecture of public power, with a share of autonomy, act as indicators of the success of federal policy to maintain and increase the level of territorial development. The subjects are both sources of stability and tension within the framework of a single state. The author concludes about the exclusive role of federal policy in the development, adoption and application of an array of legal norms reflecting the geolegal sustainability of the state and designates the federal subject as the basic structural unit for ensuring geolegal sustainability.
Analysing the role of the perceptual dimension in the formation of the urban third place
Authors: Joshi Upendra , Nagarsheth Snehal
Published: January 2025

Urban third places like parks, plazas, and cafes play a significant role in fostering social interaction, community engagement, and a sense of belonging in contemporary society, and this recognition is growing. It has been a subject of critical analysis across multiple disciplines and intellectual traditions. Although the term 'Third Place' has been the subject of considerable research for some time, a sensible investigation into the psychological needs of users broadens the study's scope, adding a new dimension to the research. This study's perceptual dimension focuses particularly on an individual's perceptions of the built environment of the urban third place.
It deals with how people perceive and experience these places. Thus, the purpose of this paper is to investigate the contribution of the perceptions that users generate in the formation of urban third places. Research begins with an understanding of this term and its significance in an urban environment. The theoretical approach interprets a perceptual dimension by analysing an individual's 'Sense of Place' in relation to the urban third place. A projective survey questionnaire further explores the concept. We decipher the qualitative observations of the survey using Nvivo, a software tool that supports both descriptive and inferential statistical inferences. The consideration of age versus the diverse perceptual needs of the users explains the interrelationship while making it convenient for the statistical analysis of the study's observations.
As a result, this research examines the significance of associations, identifies dominant perceptions, and analyses the possible patterns of the same across the identified age groups of the sample population. A statistical analysis of these observations offers insights to designers, planners, and policymakers in terms of prioritising users' experiences, needs, and preferences, i.e., sense of place, to accommodate the contemporary needs of the users in the practice of urban design at the human scale.
Architectural Laboratories
Authors: Uzal Derya , Şenel Aslıhan
Published: January 2025

This paper examines the emerging role of the laboratory in architecture, investigating how the "lab" framework has transcended its traditional scientific connotations to become integral to creative, practice-based fields. Historically understood as a controlled environment for producing reliable scientific facts, the laboratory has now been appropriated in interdisciplinary contexts, particularly in architecture, where the focus extends beyond the replication of scientific methods to the development of new research methodologies. This shift has been driven by architecture's inherent dualities—science vs. art, theory vs. practice, and living vs. non-living—compounded by increasing complexity in production. Through an exploration of laboratories in universities in detail the paper situates architecture within a possibility of a new practice supported by research. By engaging with thinkers like Bruno Latour, Karen Barad, and Bernard Stiegler, this study highlights the dynamic possibilities of architectural practice when rethinking material agency, data, and human/non-human relationships. It argues that architecture’s appropriation of the lab framework reflects a deeper engagement with the performative systems of matter, technology, and epistemology. Furthermore, the paper underscores the necessity of reconfiguring architectural practice to address contemporary challenges, by fostering new forms of action that transcend conventional boundaries of laboratory. Ultimately, this paper reveals how the laboratory in architecture is not merely a space for the application of scientific methods but a fertile ground for speculative practices and experimental methodologies that challenge established epistemological frameworks. Through this lens, the architect-agent becomes a connector, facilitating a process that resists total control and embraces open-ended, interactive systems, contributing to the creation of new forms of knowledge and practice.