bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity
Authors: Islam M. Rafiul , Hoque M. Nazmul , Rahman M. Shaminur , Alam A. S. M. Rubayet Ul , Akther Masuda , Puspo J. Akter , Akter Salma , Sultana Munawar , Crandall Keith A. , Hossain M. Anwar
Published: August 2020

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel evolutionary divergent RNA virus, is responsible for the present devastating COVID-19 pandemic. To explore the genomic signatures, we comprehensively analyzed 2,492 complete and/or near-complete genome sequences of SARS-CoV-2 strains reported from across the globe to the GISAID database up to 30 March 2020. Genome-wide annotations revealed 1,516 nucleotide-level variations at different positions throughout the entire genome of SARS-CoV-2. Moreover, nucleotide (nt) deletion analysis found twelve deletion sites throughout the genome other than previously reported deletions at coding sequence of the ORF8 (open reading frame), spike, and ORF7a proteins, specifically in polyprotein ORF1ab (n = 9), ORF10 (n = 1), and 3´-UTR (n = 2). Evidence from the systematic gene-level mutational and protein profile analyses revealed a large number of amino acid (aa) substitutions (n = 744), demonstrating the viral proteins heterogeneous. Notably, residues of receptor-binding domain (RBD) showing crucial interactions with angiotensin-converting enzyme 2 (ACE2) and cross-reacting neutralizing antibody were found to be conserved among the analyzed virus strains, except for replacement of lysine with arginine at 378th position of the cryptic epitope of a Shanghai isolate, hCoV-19/Shanghai/SH0007/2020 (EPI_ISL_416320). Furthermore, our results of the preliminary epidemiological data on SARS-CoV-2 infections revealed that frequency of aa mutations were relatively higher in the SARS-CoV-2 genome sequences of Europe (43.07%) followed by Asia (38.09%), and North America (29.64%) while case fatality rates remained higher in the European temperate countries, such as Italy, Spain, Netherlands, France, England and Belgium. Thus, the present method of genome annotation employed at this early pandemic stage could be a promising tool for monitoring and tracking the continuously evolving pandemic situation, the associated genetic variants, and their implications for the development of effective control and prophylaxis strategies.
Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns
Authors: Ämmälä Antti-Jussi , Vitikainen Emma I. K. , Hovatta Iiris , Paavonen Juulia , Saarenpää-Heikkilä Outi , Kylliäinen Anneli , Pölkki Pirjo , Porkka-Heiskanen Tarja , Paunio Tiina
Published: August 2020

Telomeres play an important role in maintaining chromosomal integrity. With each cell division, telomeres are shortened and leukocyte telomere length (LTL) has therefore been considered a marker for biological age. LTL is associated with various lifetime stressors and health-related outcomes. Transgenerational effects have been implicated in newborns, with maternal stress, depression, and anxiety predicting shorter telomere length at birth, possibly reflecting the intrauterine growth environment. Previous studies, with relatively small sample sizes, have reported an effect of maternal stress, BMI, and depression during pregnancy on the LTL of newborns. Here, we attempted to replicate previous findings on prenatal stress and newborn LTL in a sample of 1405 infants using a qPCR-based method. In addition, previous research has been expanded by studying the relationship between maternal sleep quality and LTL. Maternal prenatal stress, anxiety, depression, BMI, and self-reported sleep quality were evaluated with self-reported questionnaires. Despite sufficient power to detect similar or even considerably smaller effects than those previously reported in the literature, we were unable to replicate the previous correlation between maternal stress, anxiety, depression, or sleep with LTL. We discuss several possible reasons for the discrepancies between our findings and those previously described.
Mechanisms protect airborne green microalgae during long distance dispersal
Authors: Chiu Chia-Sheng , Chiu Pai-Ho , Yong Tze Ching , Tsai Hsin-Pei , Soong Keryea , Huang Hsiang-En , Chen Ching-Nen Nathan
Published: August 2020

Viable microalgae occur in the air. Whether they can survive the stresses such as UV, desiccation and freezing temperatures at high altitudes during long distance dispersal is rarely studied. If yes, what mechanisms confer the tolerance? Four freshwater airborne green microalgae were isolated from Dongsha Atoll in the South China Sea, classified as Scenedesmus sp. DSA1, Coelastrella sp. DSA2, Coelastrella sp. DSA3 and Desmodesmus sp. DSA6 based on their morphologies and ITS sequences. Their survival rates under UV stress were tightly correlated with their cell wall thickness. All the four airborne green microalgae survived the air-dry stress on benchtop followed by − 20 °C freeze–desiccation stress for 4 weeks, but not the two waterborne green microalgae Desmodesmus sp. F5 and Neodesmus sp. UTEX 2219-4 used as controls. Three of the four airborne microalgae survived the lyophilization treatment, excluding Desmodesmus sp. DSA6 and the two waterborne microalgae. The four airborne microalgae produced carotenoids under prolonged stress conditions, which might help detoxify the reactive oxygen species generated under environmental stresses and shield from the high-light stress in the air. Characterization of these airborne microalgae may help answer how the descendants of green algae survived on the land about 450 MYA.
Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease
Authors: Parksepp Madis , Leppik Liisa , Koch Kadri , Uppin Kärt , Kangro Raul , Haring Liina , Vasar Eero , Zilmer Mihkel
Published: August 2020

The primary objective of this study was to evaluate how schizophrenia (SCH) spectrum disorders and applied antipsychotic (AP) treatment affect serum level of amino acids (AAs) and biogenic amines (BAs) in the early course of the disorder. We measured 21 different AAs and 10 BAs in a sample of antipsychotic (AP)-naïve first-episode psychosis (FEP) patients (n = 52) at baseline, after 0.6-year as well as after 5.1-year treatment compared to control subjects (CSs, n = 37). Serum levels of metabolites were determined with AbsoluteIDQ p180 kit using flow injection analysis tandem mass spectrometry and liquid chromatography technique. Elevated level of taurine and reduced level of proline and alpha-aminoadipic acid (alpha-AAA) were established as metabolites with significant change in AP-naïve FEP patients compared to CSs. The following 0.6-year treatment restored these alterations. However, further continuous 5.1-year AP treatment changed the metabolic profile substantially. Significantly elevated levels of asparagine, glutamine, methionine, ornithine and taurine, alongside with decreased levels of aspartate, glutamate and alpha-AAA were observed in the patient group compared to CSs. These biomolecule profile alterations provide further insights into the pathophysiology of SCH spectrum disorders and broaden our understanding of the impact of AP treatment in the early stages of the disease.
A retrospective analysis of the dynamic transmission routes of the COVID-19 in mainland China
Authors: Jiang Xiandeng , Chang Le , Shi Yanlin
Published: August 2020

The fourth outbreak of the Coronaviruses, known as the COVID-19, has occurred in Wuhan city of Hubei province in China in December 2019. We propose a time-varying sparse vector autoregressive (VAR) model to retrospectively analyze and visualize the dynamic transmission routes of this outbreak in mainland China over January 31–February 19, 2020. Our results demonstrate that the influential inter-location routes from Hubei have become unidentifiable since February 4, 2020, whereas the self-transmission in each provincial-level administrative region (location, hereafter) was accelerating over February 4–15, 2020. From February 16, 2020, all routes became less detectable, and no influential transmissions could be identified on February 18 and 19, 2020. Such evidence supports the effectiveness of government interventions, including the travel restrictions in Hubei. Implications of our results suggest that in addition to the origin of the outbreak, virus preventions are of crucial importance in locations with the largest migrant workers percentages (e.g., Jiangxi, Henan and Anhui) to controlling the spread of COVID-19.
Publisher Correction: Metabolites of type I, II, III, and IV collagen may serve as markers of disease activity in axial spondyloarthritis
Authors: Hušáková Markéta , Bay-Jensen Anne-C. , Forejtová Šárka , Zegzulková Kateřina , Tomčík Michal , Gregová Monika , Bubová Kristýna , Hořínková Jana , Gatterová Jindra , Pavelka Karel , Siebuhr Anne Sofie
Published: August 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Multimodal imaging of biological tissues using combined MALDI and NAPA-LDI mass spectrometry for enhanced molecular coverage
Authors: Fincher Jarod A. , Korte Andrew R. , Yadavilli Sridevi , Morris Nicholas J. , Vertes Akos
Published: August 2020

Sequential imaging of a tissue section by MALDI and NAPA-LDI mass spectrometry provides enhanced molecular coverage.
Recent advances of BINOL-based sensors for enantioselective fluorescence recognition
Authors: Yu Fangfang , Chen Yun , Jiang Hui , Wang Xuemei
Published: August 2020

The enantioselective fluorescence recognition of BINOL-based sensors toward various chiral molecules is reviewed and the related data of enantioselectivity are listed and compared.
Size-controlled synthesis of metal–organic frameworks and their performance as fluorescence sensors
Authors: Ren Kui , Guo Xiao-Feng , Tang Ying-Jie , Huang Bo-Hui , Wang Hong
Published: August 2020

Fluorescent sensing experiments were carried out to compare the sensing performance for folic acid between bulk and nano Tb-MOFs.
Identifying C2H4N4 structural isomers using fs-laser induced breakdown spectroscopy
Authors: Zhao Y. L. , Lai G. D. , Li G. G. , Shang Y. L. , Shi J. C.
Published: August 2020

Fs-LIBS combined with multivariate analysis based on characteristic spectral information can well identify structural isomers.
Multi-component peptide hydrogels – a systematic study incorporating biomolecules for the exploration of diverse, tuneable biomaterials
Authors: Falcone Natashya , Shao Tsuimy , Andoy Nesha May O. , Rashid Roomina , Sullan Ruby May A. , Sun Xiaoyi , Kraatz Heinz-Bernhard
Published: August 2020

A systematic study showcasing a library of multi-component gels using the novel gelator C14-FF and various biocomponents for the development of tuneable matrices.
Heterogeneous photocatalytic anaerobic oxidation of alcohols to ketones by Pt-mediated hole oxidation
Authors: Sun Danhui , Li Peihe , Wang Xia , Wang Yingying , Wang Jinghui , Wang Yin , Lu Ye , Duan Limei , Sarina Sarina , Zhu Huaiyong , Liu Jinghai
Published: August 2020

We report a platinum nanocluster/graphitic carbon nitride (Pt/g-C3N4) composite solid catalyst with a photocatalytic anaerobic oxidation function for highly active and selective transformation of alcohols to ketones.
Exploration and quantification of ascorbate affecting peroxidase-catalyzed chromogenic reactions with a recirculating-flow catalysis detection system
Authors: Li Yong-Sheng , Zhao Yang , Li Qiao-Jing , Wang Ben , Gao Xiu-Feng
Published: August 2020

This research used a recirculating-flow catalysis detection system to explore the ascorbate interference with peroxidase-catalyzed reactions and simultaneously determined peroxidase and ascorbate with a kinetic curve.
Intracellular delivery of therapeutic proteins through N-terminal site-specific modification
Authors: Liew Si Si , Zhang Chengwu , Zhang Jie , Sun Hongyan , Li Lin , Yao Shao Q.
Published: August 2020

Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed for ROS-responsive targeted cancer therapy.
Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation
Authors: Del Vecchio Antonio , Talbot Alex , Caillé Fabien , Chevalier Arnaud , Sallustrau Antoine , Loreau Olivier , Destro Gianluca , Taran Frédéric , Audisio Davide
Published: August 2020

A procedure which allows labelling cyclic carbamates with all carbon isotopes has been developed. This protocol valorizes carbon dioxide, the universal building block for radiolabeling. A series of pharmaceuticals were obtained and a disconnection/reconnection strategy was implemented.
N-Iminopyridinium ylide-directed, cobalt-catalysed coupling of sp2 C–H bonds with alkynes
Authors: Kwak Se Hun , Daugulis Olafs
Published: August 2020

N-Iminopyridinium ylides are used as directing groups and internal oxidants for cobalt-catalysed annulation of sp2 C–H bonds with internal alkynes. The reactions possess excellent compatibility with heterocyclic substrates.
Correction: Development of a bidirectional isothermal amplification strategy for the sensitive detection of transcription factors in cancer cells
Authors: Zhang Yan , Li Qing-nan , Xiang Dong-xue , Zhou Kaiyue , Xu Qinfeng , Zhang Chun-yang
Published: August 2020

Correction for ‘Development of a bidirectional isothermal amplification strategy for the sensitive detection of transcription factors in cancer cells’ by Yan Zhang et al., Chem. Commun., 2020, 56, 8952–8955, DOI: 10.1039/D0CC03134H.
Unique phase behavior of a room-temperature ionic liquid, trimethylpropylammonium bis(fluorosulfonyl)amide: surface melting and its crystallization
Authors: Nishikawa Keiko , Fujii Kozo , Hashimoto Yusuke , Tozaki Ken-ichi
Published: August 2020

We investigated the phase behavior of trimethylpropylammonium bis(fluorosulfonyl)amide ([N1113][FSA]) using a laboratory-made differential scanning calorimeter (DSC), and found the unique surface-melting layer and its crystallization.
Adsorption under nanoconfinement: a theoretical–computational study revealing significant enhancement beyond the Langmuirian levels
Authors: Polak Micha , Rubinovich Leonid
Published: August 2020

Reporting fundamental deviations from classical adsorption thermodynamics, the study contributes theoretical innovation to physical nanochemistry, and is relevant to nanotechnological applications.
Electron spin polarization transfer induced by triplet–radical interactions in the weakly coupled regime
Authors: Dal Farra Maria Giulia , Martin Caterina , Bergantino Elisabetta , Kandrashkin Yuri E. , van der Est Art , Di Valentin Marilena
Published: August 2020

We report the observation of electron spin polarization transfer from the triplet state of a porphyrin to a weakly coupled nitroxide radical in a mutant of human neuroglobin (NGB).
Bis(pentafluorophenyl)-o-carborane and its arylthio derivatives: synthesis, electrochemistry and optical properties
Authors: Shida Naoki , Owaki Satoshi , Eguchi Hiroshi , Nishikawa Takanobu , Tomita Ikuyoshi , Inagi Shinsuke
Published: August 2020

The synthesis of bis(pentafluorophenyl)-o-carborane is reported, which is further thiolated by nucleophilic aromatic substitution (SNAr) reaction to give emissive materials in the solid state following aggregation-induced emission (AIE) fashion.
Visible and near-infrared driven Yb3+/Tm3+ co-doped InVO4 nanosheets for highly efficient photocatalytic applications
Authors: Zhang Kailian , Guan Jie , Mu Ping , Yang Kai , Xie Yu , Li Xiaoxiao , Zou Laixi , Huang Weiya , Yu Changlin , Dai Wenxin
Published: August 2020

A possible mechanism was proposed for the excellent photocatalytic activities. The upconversion process induced by Yb3+/Tm3+ offered the suitable energy for the activation and subsequent photocatalysis under NIR irradiation.
Terphenyl(bisamino)phosphines: electron-rich ligands for gold-catalysis
Authors: Siewert Jan-Erik , Schumann André , Fischer Malte , Schmidt Christoph , Taeufer Tobias , Hering-Junghans Christian
Published: August 2020

Simple terphenyl(bisamino)phosphines are strong donors and can be utilized as ligands in Au(i)-catalyzed intramolecular hydroamination of alyknes.
Heterogeneous epoxidation of menadione with hydrogen peroxide over the zeolite imidazolate framework ZIF-8
Authors: Ivanchikova Irina D. , Evtushok Vasilii Yu. , Zalomaeva Olga V. , Kolokolov Danil I. , Stepanov Alexander G. , Kholdeeva Oxana A.
Published: August 2020

The zeolite imidazolate framework ZIF-8 acts as a heterogeneous catalyst for epoxidation of menadione using aqueous hydrogen peroxide as the oxidant.
RAFT thermoplastics from glycerol: a biopolymer for development of sustainable wood adhesives
Authors: Forrester Michael , Becker Andrew , Hohmann Austin , Hernandez Nacu , Lin Fang-Yi , Bloome Nicholas , Johnson Grant , Dietrich Hannah , Marcinko Joe , Williams R. Chris , Cochran Eric
Published: August 2020

Glycerol–acrylic RAFT-produced thermoplastics with excellent mechanical properties and tack were used to make environmentally friendly wood adhesives.
Sample preparation with sucrose cryoprotection dramatically alters Zn distribution in the rodent hippocampus, as revealed by elemental mapping
Authors: Pushie M. J. , Hollings A. , Reinhardt J. , Webb S. M. , Lam V. , Takechi R. , Mamo J. C. , Paterson P. G. , Kelly M. E. , George G. N. , Pickering I. J. , Hackett M. J.
Published: August 2020

Transition metal ions (Fe, Mn, Cu, Zn) are essential for healthy brain function, but common sample preparations, such as sucrose cryo-protection alter their distribution, which can confound studies of brain disease.
Correction: Acoustic tweezers based on circular, slanted-finger interdigital transducers for dynamic manipulation of micro-objects
Authors: Kang Putong , Tian Zhenhua , Yang Shujie , Yu Wenzhuo , Zhu Haodong , Bachman Hunter , Zhao Shuaiguo , Zhang Peiran , Wang Zeyu , Zhong Ruoyu , Huang Tony Jun
Published: August 2020

Correction for ‘Acoustic tweezers based on circular, slanted-finger interdigital transducers for dynamic manipulation of micro-objects’ by Putong Kang et al., Lab Chip, 2020, 20, 987–994, DOI: 10.1039/C9LC01124B.
Correction: Separating extracellular vesicles and lipoproteins via acoustofluidics
Authors: Wu Mengxi , Chen Chuyi , Wang Zeyu , Bachman Hunter , Ouyang Yingshi , Huang Po-Hsun , Sadovsky Yoel , Huang Tony Jun
Published: August 2020

Correction for ‘Separating extracellular vesicles and lipoproteins via acoustofluidics’ by Mengxi Wu et al., Lab Chip, 2019, 19, 1174–1182, DOI: 10.1039/C8LC01134F.
Correction: On-chip stool liquefaction via acoustofluidics
Authors: Zhao Shuaiguo , He Weihua , Ma Zhehan , Liu Peiyao , Huang Po-Hsun , Bachman Hunter , Wang Lin , Yang Shujie , Tian Zhenhua , Wang Zeyu , Gu Yuyang , Xie Zhemiao , Huang Tony Jun
Published: August 2020

Correction for ‘On-chip stool liquefaction via acoustofluidics’ by Shuaiguo Zhao et al., Lab Chip, 2019, 19, 941–947, DOI: 10.1039/C8LC01310A.
Chemotherapeutic drug–DNA hybrid nanostructures for anti-tumor therapy
Authors: Huang Xiangang , Blum Nicholas Thomas , Lin Jing , Shi Jinjun , Zhang Chuan , Huang Peng
Published: August 2020

Design, constructions, drug loading strategies and the latest applications of chemotherapeutic drug–DNA hybrid nanostructures.
Cobalt oxide nanoparticle-decorated reduced graphene oxide (Co3O4–rGO): active and sustainable nanoelectrodes for water oxidation reaction
Authors: Munde Ajay V. , Mulik Balaji B. , Dighole Raviraj P. , Sathe Bhaskar R.
Published: August 2020

Herein, cobalt oxide (Co3O4)-decorated reduced graphene oxide (rGO)-based nanoelectrodes were fabricated by the chemical reduction method for electrocatalytic water oxidation reactions.
Structural order and charge transfer in highly strained carbon nanobelts
Authors: Aydın G. , Koçak O. , Güleryüz C. , Yavuz I.
Published: August 2020

We present a computational study of the atomic morphology, structural order and charge transfer properties of radially π-conjugated, closed-loop, and highly strained chiral carbon nanobelts (CNBs).
Anion binding with biphenyl-bis-urea derivatives: solution and solid-state studies
Authors: Grgurić Toni , Cetina Mario , Petroselli Manuel , Bacchiocchi Corrado , Dzolić Zoran , Cametti Massimo
Published: August 2020

Bis-urea derivatives1–3, featuring a biphenyl spacer, were synthesized, characterized and investigated about their anion binding properties in DMSO solution and in the solid state.
Heterogeneous catalysis by ultra-small bimetallic nanoparticles surpassing homogeneous catalysis for carbon–carbon bond forming reactions
Authors: Norouzi Nazgol , Das Mrinmoy K. , Richard Alexander J. , Ibrahim Amr A. , El-Kaderi Hani M. , El-Shall M. Samy
Published: August 2020

Heterogeneous Pd-based bimetallic catalysts supported on fumed silica with high activity and selectivity matching those of homogeneous catalysts have been developed for carbon–carbon cross-coupling reactions.
Boosting the charge transfer of Li2TiSiO5 using nitrogen-doped carbon nanofibers: towards high-rate, long-life lithium-ion batteries
Authors: Liu Junfang , Su Die , Liu Li , Liu Zhixiao , Nie Su , Zhang Yue , Xia Jing , Deng Huiqiu , Wang Xianyou
Published: August 2020

The nitrogen-doped carbon encapsulated Li2TiSiO5 (the insulator for transferring electrons by first-principles calculation) nanofibers were fabricated. And unexpectedly, it can boost the charge transfer effectively.
A theoretical review for novel Lewis base amine/imine-catalyzed reactions
Authors: Deng Qianqian , Mu Fangjing , Qiao Yan , Wei Donghui
Published: August 2020

Recent advances in computational investigations of Lewis base amine/imine-catalyzed reactions have been systematically summarized and reviewed for the first time.
Correction: Poly(hydroxy acids) derived from the self-condensation of hydroxy acids: from polymerization to end-of-life options
Authors: Gabirondo Elena , Sangroniz Ainara , Etxeberria Agustin , Torres-Giner Sergio , Sardon Haritz
Published: August 2020

Correction for ‘Poly(hydroxy acids) derived from the self-condensation of hydroxy acids: from polymerization to end-of-life options’ by Elena Gabirondo et al., Polym. Chem., 2020, 11, 4861–4874, DOI: 10.1039/D0PY00088D.
Carbon dioxide reduction by lanthanide(iii) complexes supported by redox-active Schiff base ligands
Authors: Jori Nadir , Toniolo Davide , Huynh Bang C. , Scopelliti Rosario , Mazzanti Marinella
Published: August 2020

The reduction of Ln(iii)-trensal complexes allows to store electrons, that become available for CO2 reduction, trough the formation of new C–C bonds.
Engineering a recombination neutral protease I from Aspergillus oryzae to improve enzyme activity at acidic pH
Authors: Hu Yucheng , Li Tong , Tu Zhui , He Qinghua , Li Yanping , Fu Jinheng
Published: August 2020

Extracellular neutral proteases (NPs) in Aspergillus oryzae (A. oryzae) play a role in hydrolyzing soybean proteins into smaller peptides at pH about 7.5.
A [3 + 2] cycloaddition/C-arylation of isatin N,N′-cyclic azomethine imine 1,3-dipole with arynes
Authors: Jin Qiaomei , Zhang Dongjian , Zhang Jian
Published: August 2020

A [3 + 2] annulation/C-arylation reaction of 1,3-dipole 1 with arynes has been established for the synthesis of oxindole scaffolds.
Carbohydrate-binding module O-mannosylation alters binding selectivity to cellulose and lignin
Authors: Li Yaohao , Guan Xiaoyang , Chaffey Patrick K. , Ruan Yuan , Ma Bo , Shang Shiying , Himmel Michael E. , Beckham Gregg T. , Long Hai , Tan Zhongping
Published: August 2020

Improved understanding of the effect of protein glycosylation is expected to provide the foundation for the design of protein glycoengineering strategies.
Synchronized fractionation and phase separation in binary colloids
Authors: Yao Lian Dan , Chen Hong Yu , Shi Yan , Liang Ying , Zhang Tian Hui
Published: August 2020

In binary colloids, size fractionation proceeds as two-step crystallization in which small particles and large particles crystallize sequentially.
Construction of a multi-interfacial-electron transfer scheme for efficient CO2 photoreduction: a case study using CdIn2S4 micro-flower spheres modified with Au nanoparticles and reduced graphene oxide
Authors: Li Xin , Jiang Haopeng , Ma Changchang , Zhu Zhi , Song Xianghai , Li Xiuyan , Wang Huiqin , Huo Pengwei , Chen Xiaobo
Published: August 2020

CdIn2S4 micro-flower spheres modified with Au NPs and rGO have been designed for CO2 photoreduction.
Dielectric properties and reliability enhancement of atomic layer deposited thin films by in situ atomic layer substrate biasing
Authors: Chou Chun-Yi , Chang Teng-Jan , Wang Chin-I , Wang Chun-Yuan , Yin Yu-Tung , Chung Tsai-Fu , Yang Jer-Ren , Lin Hsin-Chih , Chen Miin-Jang
Published: August 2020

The dielectric and physical properties of nanoscale thin films are significantly enhanced by atomic layer substrate biasing.
Highly efficient n-type PbTe developed by advanced electronic structure engineering
Authors: Wojciechowski Krzysztof T. , Parashchuk Taras , Wiendlocha Bartlomiej , Cherniushok Oleksandr , Dashevsky Zinovi
Published: August 2020

Advanced electronic structure engineering was applied for obtaining a record-high energy conversion efficiency for n-type PbTe.
Coexistence of relaxor behavior and ferromagnetic order in multiferroic Pb(Fe0.5Nb0.5)O3–BiFeO3 solid solution
Authors: Li Haijuan , Zhuang Jian , Bokov Alexei A. , Zhang Nan , Zhang Jie , Ren Wei , Ye Zuo-Guang
Published: August 2020

The magnetic–ferroelectric phase diagram of the (1 − x)Pb(Fe1/2Nb1/2)O3–xBiFeO3 (x ≤ 0.3) solid solution system is constructed which shows the coexistence of relaxor ferroelectric behaviour and a weakly ferromagnetic state at room temperature.
Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus
Authors: Yap Annie , Misslinger Matthias , Haas Hubertus
Published: August 2020

Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron acquisition. However, in the current study, neither growth assays on solid and in liquid media, analysis of siderophore production nor expression analysis of genes involved in iron acquisition indicated the involvement of Mac1 in the regulation of iron uptake in A. fumigatus.
WITHDRAWN: LncRNA TUG1 knockdown mitigates inflammatory injury induced by cigarette smoke extract in chronic obstructive pulmonary disease via miR-34c/BRD4 axis
Authors: Song Beibei , Wu Siyu , Ye Liyun , Jing Zeng , Cao Jing
Published: August 2020

The Accepted Manuscript version of this article (published on 19 August 2020) was withdrawn on 3 December 2020 due to concerns over data validity.
WGCNA reveals key gene modules regulated by the combined treatment of colon cancer with PHY906 and CPT11
Authors: Xing Shuqin , Wang Yafei , Hu Kaiwen , Wang Fen , Sun Tao , Li Quanwang
Published: August 2020

Irinotecan (CPT11) is one of the most effective drugs for treating colon cancer, but its severe side effects limit its application. Recently, a traditional Chinese herbal preparation, named PHY906, has been proved to be effective for improving therapeutic effect and reducing side effects of CPT11. The aim of the present study was to provide novel insight to understand the molecular mechanism underlying PHY906-CPT11 intervention of colon cancer. Based on the GSE25192 dataset, for different three treatments (PHY906, CPT11, and PHY906-CPT11), we screened out differentially expressed genes (DEGs) and constructed a co-expression network by weighted gene co-expression network analysis (WGCNA) to identify hub genes. The key genes of the three treatments were obtained by merging the DEGs and hub genes. For the PHY906-CPT11 treatment, a total of 18 key genes including Eif4e, Prr15, Anxa2, Ddx5, Tardbp, Skint5, Prss12 and Hnrnpa3, were identified. The results of functional enrichment analysis indicated that the key genes associated with PHY906-CPT11 treatment were mainly enriched in ‘superoxide anion generation’ and ‘complement and coagulation cascades’. Finally, we validated the key genes by Gene Expression Profiling Interactive Analysis (GEPIA) and RT-PCR analysis, the results indicated that EIF4E, PRR15, ANXA2, HNRNPA3, NCF1, C3AR1, PFDN2, RGS10, GNG11, and TMSB4X might play an important role in the treatment of colon cancer with PHY906-CPT11. In conclusion, a total of 18 key genes were identified in the present study. These genes showed strong correlation with PHY906-CPT11 treatment in colon cancer, which may help elucidate the underlying molecular mechanism of PHY906-CPT11 treatment in colon cancer.
Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy
Authors: Zhao Di , Zhao Yanyan , Wang Jiao , Wu Lina , Liu Yanling , Zhao Shuiying , Guo Feng , Ma Xiaojun , Zhang Haohao , Li Zhizhen , Meng Dongdong , Xu Lijun , Zhang Lixia , Liu Junqi , Qin Guijun
Published: August 2020

Background: Retinal endothelial cell (REC) dysfunction induced by diabetes mellitus (DM) is an important pathological step of diabetic retinopathy (DR). Long noncoding RNAs (lncRNAs) have emerged as novel modulators in DR. The present study aimed to investigate the role and mechanism of lncRNA Hotair in regulating DM-induced REC dysfunction.

Methods: The retinal vascular preparations and immunohistochemical staining assays were conducted to assess the role of Hotair in retinal vessel impairment in vivo. The EdU, transwell, cell permeability, CHIP, luciferase activity, RIP, RNA pull-down, and Co-IP assays were employed to investigate the underlying mechanism of Hotair-mediated REC dysfunction in vitro.

Results: Hotair expression was significantly increased in diabetic retinas and high glucose (HG)-stimulated REC. Hotair knockdown inhibited the proliferation, invasion, migration, and permeability of HG-stimulated REC in vitro and reduced the retinal acellular capillaries and vascular leakage in vivo. Mechanistically, Hotair bound to LSD1 to inhibit VE-cadherin transcription by reducing the H3K4me3 level on its promoter and to facilitate transcription factor HIF1α-mediated transcriptional activation of VEGFA. Furthermore, LSD1 mediated the effects of Hotair on REC function under HG condition.

Conclusion: The Hotair exerts its role in DR by binding to LSD1, decreasing VE-cadherin transcription, and increasing VEGFA transcription, leading to REC dysfunction. These findings revealed that Hotair is a potential therapeutic target of DR.
An Evaluation of an Integrated Stuttering and Parent-Administered Self-Regulation Program for Early Developmental Stuttering Disorders
Authors: Druker Kerianne , Mazzucchelli Trevor , Hennessey Neville , Beilby Janet
Published: August 2020

Purpose

This study reports findings from a clinical trial that implemented an early stuttering treatment program integrated with evidence-based parenting support (EBPS) to children who stutter (CWS) with concomitant self-regulation challenges manifested in elevated attention-deficit/hyperactivity disorder (eADHD) symptoms and compared those outcomes to CWS receiving stuttering treatment without EBPS.

Method

Participants were 76 preschool CWS and their parent(s). Thirty-six of these children presented with eADHD and were quasirandomized into two groups: stuttering treatment only (eADHD
standard
) or stuttering treatment integrated with EBPS (eADHD
integrated
). The remaining children did not meet criteria for eADHD symptoms and received stuttering treatment only (No-eADHD
standard
). Pre, post, and 3-month follow-up measures of stuttering treatment outcomes as well as treatment effects on measures of child behavior difficulties and parenting practices were examined.

Results

Significant reduction in stuttering was found for all groups. However, the eADHD
integrated
group showed a greater reduction in stuttering frequency than the eADHD
standard
group, and at follow-up, stuttering frequencies in the eADHD
integrated
group matched those of children in the No-eADHD
standard
group, while stuttering in the eADHD
standard
group remained significantly higher. Children with eADHD symptoms who received the integrated program also required significantly less stuttering intervention time than those children with eADHD symptoms who received stuttering treatment only. Families in the eADHD
integrated
group reported large and significant improvements in child behavior and parenting practices.

Conclusion

This study provides support for an early treatment program for CWS. The integrated stuttering and self-regulation management program for CWS with eADHD symptoms proved successful for fluency and behavioral improvements, which were sustained at follow-up.
Structure and Topography Modifications of Treated AISI 316LN Stainless Steel Surfaces after Friction in Dry Sliding Contact by Case Hardening Process
Authors: Gandhi M. Mamatha , Bain Animesh , Rohith P , Srilatha R. , Subbiah Ram
Published: August 2020

Austenitic stainless is having corrosion resistance property, but certain mechanical applications require improved resistance to wear, inferior cavitation, susceptibility to sensitization. These steels have numerous favourable circumstances for great cryogenic - properties, anti-corrosion, and bio-compatibility. So these steels have a broad application in low temperature innovation, saltwater applications, nourishment industry, bio-medicine, petro-chemical handling, and so forth when alloyed with nitrogen, austenitic treated steels has a progressively steady austenite structure, better mechanical properties and better wear opposition, which has animated extraordinary enthusiasm for this exploration work. Many surface hardening techniques are available, the best surface modification technique is chosen for improved service performance. Surface engineering is a technique to alter the surface of a material by mechanical or microchemical method without affecting the material properties. The alterations are done on the surfaces subjected to the liquid nitriding process to produce a hardened surface. Chosen for this research workbased on their wide application, the wear behaviour of AISI 316LN stainless steels was investigated. Of the various surface hardening techniques available, nitriding is chosen, so that these nitrogen gets penetrated into the material, in which hard iron chromium nitrides are formed at the surface level. AISI 316LN specimens were subjected to salt bath nitriding process. The specimens were nitrided to 60 minutes, 120 minutes and 180 minutes respectively. The specimens were undergone with wear tests by standardized tribiological wear machine and finally the metallographic studies were made.
New Insights of Wear Behavior Analysis on Low Temperature Treated AISI 253MA Stainless steel Material by Gas Nitriding Process
Authors: Sree K. Ramya , Reddy G. Keerthi , Aishwarya K. , Devi E. Nirmala , Subbiah Ram.
Published: August 2020

AISI 253MA Stainless steel samples were treat with the gas nitrating process at low heat around 450°C. It was seen that all-inclusive austenite stage exist when it is nitrade to 8 hours and post addition at time of nitrading to 16 hours the mix of ferrites and progressively substance of nitrogen was gathered in the following layers. Farther nitrading to 24 hour it has seen at Cr-N stage was discovered and turns the steel progressively firmer superficially. Erode tests were led by tribological wear testing machine to examine the tribological wear loss. Volume wear was found to be least in 18 hours test which demonstrated better improvement of wear improvement. High hardness were found in 24 hrs showing a hardness of 1080Hv. The sample nitrided to 24 hours exhibited better wear resistance, high hardness and low wear loss as well as low volume wear loss. Assessment examinations of nitrided test samples were investigated under scanning electron magnifying analysis.
Influence of Process Parameters on Physical and Mechanical Parameters of Friction Surfaced Deposits on Low Carbon Steel
Authors: Sekhar S. Ravi , Govardhan D. , Karthikeyan R , Subbaiah Ram
Published: August 2020

Friction surfacing is the innovative technique employed for the reformation of a metal surface. Frictional heat produced between two interaction surfaces is utilized to deposit one metal above the other professionally. In this process, the quantity heat needed for depositing is essentially be influenced by on choice of process constraints such as friction force, revolving speediness of mechtrode, table speediness and reside duration. Stainless steel was selected for friction surfacing on mild steel in this experiment, the number of experiments were decided based on factorial design. Investigational task of friction surfacing was executed and the responses were quantified from the deposits which were accepted after thorough inspection. Through regression equations the impact of procedure features on each response was determined.
Role of Big Data Analytics in Power System Application
Authors: Angadi Ravi V , Venkataramu P. S , Daram Suresh Babu
Published: August 2020

Power system sector is the back bone for any country economic growth. In current years, electric power systems have experienced various challenges and technological innovations and have become digitalized with the introduction concept of smart grids. Power systems are being operated in a stressed condition mainly due to the ever increasing load demand, depleting energy resources and environmental constraints on Transmission line expansion. This article focus mainly role of Big Data in various industrialization in brief and specifically applied in the power system studies along with other sectors. Also focuses on using very large data collections, which are difficult to access in standard database systems and also refers to as big data, to manage and monitor the power system. System stability is an significant goal for power engineers to use this huge amount of data to run the system in their rated capacity, power sector can beneficial of various potential solicitation of power system by the use of large-scale data analysis that can help improve the optimization process and helps for the power system to operate in the effective manner.
Investigation of Mechanical Properties of AISI 316 Stainless Steel by Carbonitriding Process
Authors: Rohit Sai Krishna A , Vamshi Krishna B , Harshith D , Sashank T , Subbiah Ram
Published: August 2020

This project investigates on salt bath nitriding process in order to improve the wear behavior of the material. This process increases the hardness of the material. The specimens were nitrided at 580°c on three different timing hours such as 60 minutes, 90 minutes & 120 minutes. A pin on disc machine is used to conduct wear test, so that wear loss can be determined. The specimens are to be magnified by metallographic test like scanning electron microscope. The untreated specimen is used to compare with the nitrided specimen. The best specimen is chosen which determines the life of material & improves the better wear resistance. The hardness of untreated material and nitrided material are compared. The material AISI stainless steel has many unique properties but it lacks wear resistance and hardness because of which it has limited applications. By conducting heat treatment operation, the hardness of the material does not improve, but by conducting case hardening process the hardness of the outer case will be high compared to base metal. If the hardness and wear resistance of the material improves the material can be used in wide range of applications.
Evaluation of properties of AISI 431Grade Stainless Steel by Vacuum Annealing Process
Authors: Lakshmi Prasanna Gandla , Keerthi Reddy G. , Ram Subbiah Dr.
Published: August 2020

The wear behaviour of AISI 431stainless steel was investigated at consistent load under a dry sliding touch with vacuum annealing device. The approach implemented was found to have been effective in improving the wear actions of stainless steel products, advancing the pliability properties. For Vacuum Annealed (VA1) 2 hours, Vacuum Annealed (VA2) 4 hours and Vacuum Annealed (VA3) 6 hours respectively, a low temperature heat treatment was performed on sample for the maximum annealing cycle. Untreated stainless steel (UNT) was used as a kind of viewpoint tool for contrast with specific hardening samples and conducted wear checks. The hardening samples show certain hard formed layers which enhance the hardness of the surface. Estimations of small scale toughness showed a crucial improvement in toughness following operation. This method raises the hardness of the substance up to 150 percent. A pin on the disc drive is used to do wear checking to assess wear failure. The layers were represented by optical lens magnification and the examination of electron magnifying glass.
IMPROVEMENT OF CHARACTERISTICS OF AISI 310 GRADE STAINLESS STEEL MATERIAL BY CARBURIZING
Authors: Vamshi Manne , Saranya J. , Subbiah Ram
Published: August 2020

. The investigation on the microstructure and mechanical behaviour of steel AISI 310 has been carried out during a Carburizing process aiming to improve the wear performance. The comparision study was made to treated specimens with untreated sample. Carburizing is a viable technique to enhance the wear resistance of the stainless steel material. The present study focused in the direction of investigating the effect of microstructure, hardness and wear resistance of AISI 310 stainless steel material. In carburizing process the case depth is found to be 11.5, 12, 14 Microns which is treated 2 hrs, 4hrs and 6 hrs respectively. The combination action of strong adhesion, abrasion and severe plastic deformation are the primary reasons for the continuous material loss in the untreated specimens during testing. The Optical microscope, SEM analysis and wear test are conducted to find out the various results
Effect of permeability on GFRP laminate produced by VARTM process
Authors: Shankarachary Bairoju , Sateesh N , Gopinath Lavu , Aparna Siripuram
Published: August 2020

Vacuum assisted resin transfer molding (VARTM) is one of the manufacturing technique that is viable for production of fiber reinforced polymer composite components suitable for aerospace, marine and commercial applications. However the repeatable quality of the product can be achieved by critically fixing the process parameters such as Vacuum Pressure (VP) and permeability of the preform. The present investigation is aimed at studying the effect of permeability for production of Glass Fiber Reinforced Polyester (GFRP) components with consistent quality. The VARTM mould is made with an acrylic transparent top cover to observe and record the resin flow pattern. Six layers of randomly placed glass fiber under five different vacuum pressures VP1 = 0.013, VP2 = 0.026, VP3 = 0.039, VP4 = 0.053 and VP5 = 0.066 MPa were studied. The laminates produced by this process under the above mentioned conditions were characterized with ASTM D procedures so as to study the effect of these process parameters on the quality of the laminate. And as mentioned there is a considerable effect of permeability on the impact strength and the void content in the laminates under different vacuum pressures. SEM analysis of the impact tested fractured GFRP composites showed the bonding of fiber and matrix.
A Survey on Hybrid Machine Translation
Authors: Anugu Anusha , Ramesh Gajula
Published: August 2020

Machine translation has gradually developed in past 1940’s.It has gained more and more attention because of effective and efficient nature. As it makes the translation automatically without the involvement of human efforts. The distinct models of machine translation along with “Neural Machine Translation (NMT)” is summarized in this paper. Researchers have previously done lots of work on Machine Translation techniques and their evaluation techniques. Thus, we want to demonstrate an analysis of the existing techniques for machine translation including Neural Machine translation, their differences and the translation tools associated with them. Now-a-days the combination of two Machine Translation systems has the full advantage of using features from both the systems which attracts in the domain of natural language processing. So, the paper also includes the literature survey of the Hybrid Machine Translation (HMT).
ANN based Battery Health Monitoring - A Comprehensive Review
Authors: Bhagavatula Sai Vasudeva , Yellamraju Venkata Rupesh Bharadwaj , Eltem Karthik Chandra , Bobba Phaneendra Babu , Marati Naveenkumar
Published: August 2020

The development of electric vehicles has bought a great revolution in the field of battery management as it deals with the health of the battery and also the protection of the battery. State of Charge (SoC) and State of Health (SoH) are the important parameters in determining the battery’s health. Advancements in Artificial Neural Networks and Machine Learning, a growing field in recent years has bought many changes in estimating these parameters. Access to huge battery data has become very advantageous to these methods. This manuscript presents an overview of different Artificial Neural Network techniques like Feedforward Neural Network (FNN), Extreme Learning Machine (ELM), and the Long Short Term Memory (LSTM). These techniques are trained with already existing data samples consisting of different values of voltages, currents at different temperatures with different charging cycles and epochs. The errors in each technique are different from the other as the constraints in one method are rectified using the other method to get the least error percentage and get the nearest estimate of the SoC and SOH. Each method needs to be trained for several epochs. This manuscript also presents a comparison of different methods with input parameters and error percentages.
Model Predictive Controller based Unified Power Quality Conditioner for Voltage Regulation Studies in 33- Bus Closed Loop Distribution System
Authors: Pasha SK. Abdul , Kumar N. Prema
Published: August 2020

Recent developments in FACTS have produced U.P.Q.C to mitigate sag and attenuate THD. U.P.Q.C has been urbanized as a FACTS controller between feeding end & far end of distribution system .The U-P-Q-C is capable of improving the voltage profile & reducing THD of distribution system by regulating the voltage using PR (Proportional-Resonant-Controller) and MPC (Model-Predictive) controller. This work proposes U-P-Q-C for Thirty Three Bus Systems .The objective of this work is to enhance-voltage-profile of T-T-B-S. The T-T-B-S in open loop & closed loop-TTBS- U-P-Q-C using PR and MPC-controllers are-modeled,pretend & their consequences are represented. Responses are estimated as a time of settle and error in steady state. The outcomes indicate that MP Controlled T-T-B-S system has better response than PR controlled T-T-B-S system.
Stress-Strain behaviour of basalt fibre reinforced concrete
Authors: Goud E Giri Prasad , Singh Dinesh , Reddy V Srinivasa , Reddy Kaveli Jagannath
Published: August 2020

This paper prophesies the stress strain behaviour of M30 grade concrete reinforced with basalt fibres of length 12 mm, 36 mm and 50 mm of amounts 0.4%, 0.4% and 0.3% by volume of concrete respectively. Modulus of elasticity and toughness of M30 grade basalt fibre reinforced concretes are also evaluated. It was found that BFRCC mixes show good resistance to impact and has superior dissipation capacity. The optimal basalt fibre volume fraction is 0.3% and length is 50 mm. For this case, toughness index and energy absorbed at fracture have considerably enhanced. With the volume fraction of basalt fiber exceeding the optimum volume fraction, the mechanical properties of basalt fiber are weakened.