bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of hepatitis A virus antibodies in Central-Eastern Poland – a comparative study (1990-2012)
Authors: Pachnia Dariusz , Polz-Gruszka Dorota , Macielag Pawel , Polz-Dacewicz Malgorzata
Published: March 2018

Hepatitis A virus (HAV) is an hepatotropic human picornavirus that is associated only with acute infection of liver. This pathogen is mainly transmitted through the faecal-oral route, by person-to-person contact, and also contaminated drinking water and food. This reserach presenting the comparative seroepidemiological study (1990/1999/2012) on HAV infection was carried out in population from south-eastern Poland. Anti-HAV was tested in 613 subjects from 0 to over 60 years of age and the results were compared with those observed in 1990 and 1989/99. We also analyzed the number of vaccinations in the past decade and their role in preventing disease.
FAPA mass spectrometry of hydroxychalcones. Comparative studies with classical methods of ionization
Authors: Smoluch Marek , Bartkowiak Grazyna , Reszke Edward , Lechowicz Wojciech , Silberring Jerzy , Schroeder Grzegorz
Published: March 2018

In this paper we are focused on analysis of hydroxychalcones, i.e. 2’-hydroxychalcone, 3’-hydroxychalcone and 4’-hydroxychalcone, by the Flowing Atmospheric Pressure Afterglow mass spectrometry (FAPA-MS), and on comparison of the obtained data with other classical methods including ESI-MS, APCI, MALDI, and GC/EI-MS. The paper is presenting fragmentation pathways of both positive-, and negative hydroxychalcone ions. Tested compounds were characterized by comparison of the results (signals m/z and relative intensities) from the five mass spectrometry techniques, showing very good utility of FAPA method for fast and easy analysis of the low molecular weight compounds. Moreover, FAPA does not require a time-consuming derivatization, nor search for a suitable solvent or matrix, often incompatible with various ion sources.
An analysis of potential costs of adverse events based on Drug Programs in Poland. Pulmonology focus
Authors: Szkultecka-Debek Monika , Drozd Mariola , Jahnz-Rozyk Karina , Kiepurska Nina , Mazurek Joanna , Janowska Agnieszka , Paprzycki Piotr , Adamczyk-Korbel Marta , Paluchowska Beata , Drozd Kazimierz
Published: March 2018

The project was performed within the Polish Society for Pharmacoeconomics (PTFE). The objective was to estimate the potential costs of treatment of side effects, which theoretically may occur as a result of treatment of selected diseases. We analyzed the Drug Programs financed by National Health Fund in Poland in 2012 and for the first analysis we selected those Programs where the same medicinal products were used. We based the adverse events selection on the Summary of Product Characteristics of the chosen products. We extracted all the potential adverse events defined as frequent and very frequent, grouping them according to therapeutic areas. This paper is related to the results in the pulmonology area. The events described as very common had an incidence of ≥ 1/10, and the common ones ≥ 1/100, <1/10. In order to identify the resources used, we performed a survey with the engagement of clinical experts. On the basis of the collected data we allocated direct costs incurred by the public payer. We used the costs valid in December 2013. The paper presents the estimated costs of treatment of side effects related to the pulmonology disease area. Taking into account the costs incurred by the NHF and the patient separately e calculated the total spending and the percentage of each component cost in detail. The treatment of adverse drug reactions generates a significant cost incurred by both the public payer and the patient.
Cytotoxic activity of ethanolic extracts of Eleutherococcus species cultivated in Poland on HL60 leukemia cell line
Authors: Zaluski Daniel , Smolarz Helena Danuta , Bogucka-Kocka Anna
Published: March 2018

The Eleutherococcus species including 40 species native to Asia are medicinal plants widely used in traditional medicine. Some of these species are cultivated at the botanical gardens in Europe. On the basis on our earlier studies it was concluded that the extracts of analyzed species act as antioxidants, inhibitors of MMPs, and cytotoxic against Jurkat 45 leukemia cell line. In this study, the anti-leukemic potential of roots and leaves from six Eleutherococcus species cultivated in Poland was determined. The in vitro cytotoxic activity towards human promyelotic leukemia cell line HL60 using trypan blue assay was evaluated. The induction of apoptosis in stimulated leukemia cells was determined by AnnexinV method. Morphological changes in treated cells were observed by microscopic investigations.

The results showed that ethanolic extracts from the roots and the leaves of E. senticosus, E. setchuensis, E. sessiliflorus, E.gracilistylus, E. henryi and E. divaricatus exhibit cytotoxic effect towards leukemic HL60 cells. The received IC50 values for roots ranged from 49- 208 μg/mL and for the leaves from 116-518 μg/mL. The ethanol extract from the roots of E. divaricatus showed the highest cytotoxic and proapoptotic effect on HL60 human lymphoid leukemia cell line.
Influence of the dissolution medium on the release of dehydroepiandrosterone from lipophilic suppositories
Authors: Kasperek Regina , Galczynski Krzysztof , Nalesniak Magdalena , Iwaniak Karol , Poleszak Ewa
Published: March 2018

Suppositories with cocoa butter containing dehydroepiandrosterone (DHEA) without and with the addition of Span 80 and Tween 80 as surfactants with low and high HLB values were prepared. The physical properties and the drug content of all prepared suppositories were in accordance with the pharmacopoeial requirements. The release study tests in three dissolution media such as water, lactic acid solution at pH 4.2 and phosphate buffer at pH 7.4 were carried out. In acidic and alkalic media only about 10% and 27% of DHEA were released, respectively. The addition of Span 80 to the suppository mass did not improve the release process, but the addition of Tween 80 caused the increase in the amount of DHEA released in the acidic medium to about 35%. The data showed that rectal administration of suppositories with DHEA based on cocoa butter caused about 30% availability and after vaginal administration, only topical activity can be expected. By the addition of Tween 80 to the suppository mass availability of DHEA of about 35% from vaginal suppositories can be achieved.
Essential oil composition and variability of Hypericum perforatum L. from wild population in Kosovo
Authors: Hajdari Avni , Mustafa Behxhet , Nebija Dashnor , Kashtanjeva Albana , Widelski Jaroslaw , Glowniak Kazimierz , Novak Johannes
Published: March 2018

Aerial parts of Hypericum perforatum L. (Hypericaceae) were collected from five wild populations in Kosovo, with aim to investigate the chemical composition and natural variation of essential oils between wild populations. This species could be considered of economic potential as it is widespread in Kosovo, on the other hand H. perforatum is one of the best-known medicinal herbs used in Kosovo folk medicine. Essential oils were obtained by steam distillation and analysed by GC-FID and GC-MS. Sixty-seven components were identified. The yields of essential oils differed depending on the population and ranged from 0.04 to 0.26% based on dry weight. The aerial parts of H. perforatum were characterized by the following main constituents: 2-methyl-octane (1.1-15.5%), α-pinene (3.7-36.5%), β-caryophyllene (1.2-12.4%), caryophyllene oxide (3.3-17.7%) and n-tetradecanol (3.6- 10.4%). Hierarchical cluster analysis revealed that the concentration of components depends on the origin of the plant populations, thus α-pinene and 2-methyl-octane were present in the highest concentration in population originating from Gjakove, Prizren and Ferizaj, whereas in the populations originating from Peje and Prishtine the most abundant constituents were caryophyllene oxide, β-caryophyllene and n-tetradecanol. Further investigation is needed to establish the natural variability and chemopolymorphism of this species in the territory of Kosovo, which should be supported by molecular level analyses.
Effect of N-(m-bromoanilinomethyl)-p-isopropoxyphenylsuccinimide on the anticonvulsant action of four classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model
Authors: Luszczki Jarogniew J. , Marzeda Ewa , Kondrat-Wrobel Maria W. , Pyrka Daniel , Kocharov Sergey L. , Florek-Luszczki Magdalena
Published: March 2018

The purpose of this study was to determine the effects of N-(m-bromoanilinomethyl)- p-isopropoxyphenylsuccinimide (BAM-IPPS - a new succinimide derivative) on the protective action of four classical antiepileptic drugs (AEDs: carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT] and valproate [VPA]) in the mouse maximal electroshock (MES)-induced tonic seizure model. Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via ear-clip electrodes. BAM-IPPS administered (i.p.) at a dose of 150 mg/kg significantly elevated the threshold for electroconvulsions in mice (P<0.05). Lower doses of BAM-IPPS (50 and 100 mg/kg) had no significant impact on the threshold for electroconvulsions in mice. Moreover, BAM-IPPS (100 mg/kg) did not significantly affect the anticonvulsant potency of CBZ, PB, PHT and VPA in the mouse MES model. BAM-IPPS elevated the threshold for electroconvulsions in mice in a dosedependent manner. However, BAM-IPPS (100 mg/kg) did not affect the anticonvulsant action of various classical AEDs in the mouse MES model, making the combinations of BAM-IPPS with CBZ, PB, PHT and VPA neutral, from a preclinical point of view.
Phenolic substances in Ailanthus glandulosa Desf
Authors: Pekala Karolina , Wawrzusiszyn Katarzyna , Bogucka-Kocka Anna
Published: March 2018

The aim of this work was the isolation and identification of phenolic acids from fruit and leaves of Ailanthus glandulosa Desf. The methods used in the isolation and identification of the compounds were: isolation of phenolic acids modified by Ibrahim and Towers, acidic and alkaline hydrolysis by Schmidtlein and Herrmann and identification of phenolic acids in the isolated fraction of two-dimensional thin layer chromatography (TLC) on cellulose plates. In the course of the study, the presence of phenolic acids in leaves and fruit of Ailanthus glandulosa Desf was confirmed. Overall, proportions of 15 phenolic acids were found and identified in the analyzed material. These are: gallic acid, ellagic acid, caffeic acid, gentisic acid, protocatechuic acid, p-hydroxybenzoic acid, m-hydroxybenzoic acid, ferulic acid, p-coumaric acid, syryngic acid, vanillic acid, salicylic acid, 2-hydroxy-4- methoxybenzoic acid, 2,5-dimethoxycinnamic, p-hydroxyphenylacetic acid, and 3 other compounds named A, B, C, whose identification was not possible due to the lack of suitable reference patterns. Studies have shown that leaves and fruit of the plant Ailanthus glandulosa Desf. contain a large number of phenolic acids which possess many important pharmacological activities.
The influence of proteasome inhibitor on the expression of cardiomyocytes damage markers after incubation with doxorubicin
Authors: Tereszkiewicz Sylwia , Matysiak Wlodzimierz , Mandziuk Slawomir , Korga Agnieszka , Oleksiejuk Malgorzata , Hejna Marcin , Korobowicz-Markiewicz Agnieszka , Iwan Magdalena , Dudka Jaroslaw
Published: March 2018

The aim of the study was to verify the thesis that the cardiotoxic effects of doxorubicin are connected with activation of the ubiquitin - proteasome pathway followed by protein degradation. The expression of myocardial damage markers - fatty acid binding protein (H-FABP) and brain natriuretic peptide (BNP) was evaluated in rat fetal cardiomyocytes simultaneously treated with doxorubicin and the proteasome inhibitor - bortezomib. The level of H-FABP and BNP protein under the influence of doxorubicin was decreased below the detection threshold with unchanged (H-FABP) or elevated (BNP) mRNA expression level. Against the expectations, the inhibitor of proteasome did not abolish this effect. The observed abnormal expression of BNP and H-FABP protein after doxorubicin treatment makes their diagnostic significance in anthracycline cardiotoxicity questionable.
The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes
Authors: Rahnama Mansur , Lobacz Michal , Szyszkowska Anna , Trybek Grzegorz , Kozicka-Czupkallo Maryla
Published: March 2018

In adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes. In menopausal period, female patients experience gradual reduction in blood estradiol levels. The deficit of estrogens leads to enhanced osteoclastogenesis and bone resorption. Alkaline phosphatase (ALP) is a membranebound enzyme that stimulates the osteoblast activity and bone mineralization. It is synthesized by osteoblasts and incorporated into the newly formed bone tissue. The produced enzyme stimulates the osteoblast activity and bone mineralization. The goal of this study is to determine the effect of hormone replacement therapy in postmenopausal women on the expression of alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes. The studies show that hormone replacement therapy has no significant effect on the increase in ALPL expression within the mucosal epithelium of the cheek. Only in women having undergone ovarectomy (OV), the epithelial ALPL expression level was higher than in the remaining groups.
Comparison of visual, impedance spectroscopy and laser fluorescence methods in detecting early carious lesions on occlusal surfaces
Authors: Chalas Renata , Wojcik-Checinska Ilona , Zubrzycka-Wrobel Joanna , Piatek Dominika , Bachanek Teresa
Published: March 2018

The diagnostic management is a very important and integral part of the entire treatment process and has a direct influence on the decision-taking on the choice of the most appropriate form of therapy consistent with current knowledge. Knowledge of the morphology of hard dental tissues lesions has led to the development of quantitative methods for diagnosis and monitoring of dental caries, which enabled the implementation of appropriate treatments aimed at repairing than replacing damaged tissue. The aim of the study was to compare selected diagnostic methods: visual (ICDAS), impedance spectroscopy (CarieScan PRO) and laser fluorescence (Diagnodent Pen) in detecting caries in grooves on the chewing surfaces of molars and premolars. The obtained results indicated a high concordance of measurements performed with the Diagnodent Pen with the results of visual examination and a lower compliance of visual examination with the results obtained using the CarieScan PRO. A combination of visual and tactile method with tests using advanced technology provides greater opportunity to confirm the diagnosis of carious lesions requiring medical intervention.
Different faces of a febrile state
Authors: Rymarz Ewa , Milaniuk Sylwia , Prystupa Andrzej , Mosiewicz Jerzy
Published: March 2018

Fever develops in various diseases. It is mainly associated with infectious diseases but can also occur in non-infectious ailments. Clinical symptoms are not always explicit, which can hinder the diagnosis and delay the institution of appropriate treatment. The aim of the study is to present difficulties in diagnosing the cause of a febrile state in a patient with splenic abscess.
Is there any benefit of harmonic scalpel for hemorrhoidectomy versus conventional diathermy?
Authors: Yıldırım Doğan , Dönmez Turgut , Aktürk Okan Murat , Kocakuşak Ahmet , Çakır Mikail , Yurtteri Mustafa Ertuğrul
Published: March 2018

Aim: Symptomatic hemorrhoidal disease is among the most common surgical diseases and it may necessitate surgical intervention. The most common and effective approaches used for surgical treatment are harmonic scalpel hemorrhoidectomy and conventional diathermy excision. The aim of the study was to compare the outcomes of hemorrhoidectomy using harmonic scalpel and the conventional diathermy excision techniques. Methods: The files of 113 consecutively operated patients (26 females 23%, 87 males 77%), who were operated on for symptomatic Grade III–IV hemorrhoids, were retrospectively reviewed for length of operation and hospitalization, early and delayed bleeding, urinary retention, postoperative abscess and anal stenosis. Exclusion criteria were additional operations, recurrent cases and inflammatory bowel disease. Results: Conventional diathermy hemorrhoidectomy in 60 (53%) and harmonic scalpel hemorrhoidectomy were used in 53 patients (47%). There were significant differences between the operation and hospitalization times in favor of harmonic scalpel group (p<0.05 for both). The other parameters did not show any significant differences (p>0.05 for all). Conclusion: Harmonic scalpel hemorrhoidectomy is advantageous and superior to conventional diathermy hemorrhoidectomy in regard to shorter operation time and earlier discharge from the hospital with no additonal complications.
Persepsi Resiko Bencana Alam Ditinjau dari Sentralitas Jaringan Informasi Kebencanaan
Authors: Wusana Sapta Widi , Hidayat Rahmat
Published: March 2018

This research aims to understand the risk perception of Merapi disaster in hazardous community, based on social network centrality. Quantitative approach with psychology scale is used to reveal perceptions of volcanic risk of Merapi, collaborated with name generator to reveal index of social network centrality from 83 people. Result of this research proves that degree, betweeness, closeness, and eigenvector centrality all together are able to predict Merapi’s disaster risk perception, with 17% coefficient determination value (R2). Which means that the research hypothesis is convicted. Separately, betweenness, closeness and eigenvector centrality contribute negatively with perceptions of Merapi volcanic risk. Strong, influential and independent actors consider the potential danger of Merapi as predictable and avoidable. The availability of support, information and access further enhances confidence in the ability of the self to control the impact of Merapi exposure. Conversely, peripheral actors have concerns and more assumptions about the dangers of Merapi, which results from a lack of information, access, support that ultimately reduces his beliefs.
Propertis Psikometris Skala Sikap Terhadap Pelajaran Sosial Humaniora
Authors: Periantalo Jelpa
Published: March 2018

The purpose of research was to assess psychometric properties of scale attitude toward social sciences subject: Economics, Sociology, History and Geography. Psychometric properties consisted of validity, reliability and item discrimination. The subjects were  198 high school students with purposive sampling method. Scale used semantic differensial format  with overall 68 items. One item unpassed, 67 items passes selection with rit ≥ 0,400. Factorial validity confirmed 3 assumed factors: activity, evaluation and potential. Convergent validity showed positive correlation among subscale. The parallel test reliability showed of equivalent coefficient rxx’ 0,939. The final scale consisted of 12 items, easily in used and scoring. The scale could be used for research, external validation of other scale, high school majoring, educational counseling, learning evaluation, education intervension and university majoring. The next research was to validate with  external criterion especially academic achievement.
Front Cover, Masthead, Boards and Contents
Authors: Atsan Emre
Published: March 2018

FSECON, Volume 2, Special Issue 1 / State and Development in the 21st Century Published: 28 February 2018
Guest-Dependent Stabilization of the Low Spin State in Spin-Crossover Metal-Organic Frameworks
Authors: Pham C. Huy , Lab Paesani
Published: March 2018

Computer simulations are carried out to characterize the variation of spin crossover (SCO) behavior of the prototypical {Fe(pz)[Pt(CN)4]} metal-organic framework (MOF) upon adsorption of chemically and structurally different guest molecules. A detailed analysis of both strength and anisotropy of guest molecule-framework interactions reveals direct correlations between the mobility of the guest molecules inside the MOF pores, the rotational mobility of the pyrazine rings of the framework, and the stabilization of the low-spin state of the material. Based on these correlations, precise molecular criteria are established for predicting the spin state of {Fe(pz)[Pt(CN)4]} upon guest adsorption. Finally, predictions of the SCO temperature upon adsorption of various toxic gases demonstrate that in silico modeling can provide fundamental insights and design principles for the development of spin-crossover MOFs for applications in gas detection and chemical sensing.
Synthesis of Mesoscale, Crumpled, Reduced Graphene Oxide Roses by Water-in-Oil Emulsion Approach
Authors: Sharma Shruti , Pham Viet Hung , Boscoboinik Jorge A. , Camino Fernando , Dickerson James H. , Tannenbaum Rina
Published: March 2018

Mesoscale crumpled graphene oxide roses (GO roses) were synthesized by using colloidal graphene oxide (GO) variants as precursors for a hybrid emulsification/rapid evaporation approach. This process produced rose-like, spherical, reduced mesostructures of colloidal graphene oxide, with corrugated surfaces and particle sizes ranging from ~800 nm to 15 μm. The morphology and chemical structure of these produced GO roses was investigated using electron microscopy and spectroscopy techniques. The proposed synthesis route provides control over particle size, morphology and chemical properties of the synthesized GO roses.
A REFORMA GERENCIAL NO BRASIL E AS POSSIBILIDADES DE VIABILIZAR DIREITOS SOCIAIS, POLÍTICOS E ECONÔMICOS
Authors: Miranda Lara Caxico Martins , Kempfer Marlene
Published: March 2018

Apropriando-se do método dedutivo, a pesquisa bibliográfica analisa a intervenção do Estado sobre o domínio econômico para viabilizar direitos sociais, políticos e econômicos conforme os pilares do Estado liberal e social. Atualmente, fortes são as tendências neoliberais e grande a modificação do posicionamento do Estado com relação a esses direitos. Defende-se que o Brasil absorveu os ideais do neoliberalismo e de conquistas sociais na Constituição Federal de 1988, mas apenas com a Emenda Constitucional n. 19 de 1998 e a implementação da reforma gerencial foi possível incorporar as conquistas obtidas em lutas políticas, sociais e econômicas do Estado moderno.
CONSÓRCIOS INTERMUNICIPAIS PARA LICENCIAMENTO AMBIENTAL: UM INSTRUMENTO DE GARANTIA DO DIREITO FUNDAMENTAL À BOA ADMINISTRAÇÃO PÚBLICA
Authors: Da Silva Corralo Giovani , Moura da Silva Boanova Aline
Published: March 2018

O  meio ambiente remete à dicotomia entre desenvolvimento e sustentabilidade. No ordenamento brasileiro o protagonismo do município em questões desse tipo é inegável. O estudo tem por objetivo demonstrar que o consórcio intermunicipal para licenciamento ambiental é um importante instrumento de garantia do direito fundamental à boa administração pública. Especificamente abordaremos questões como: consórcios intermunicipais, direito ambiental, competências constitucionais e o licenciamento ambiental de interesse local descrito na Lei Complementar 140 de 2011. Como resultado concluímos que o consórcio intermunicipal para licenciamento ambiental é a melhor forma de garantir o direito fundamental à boa administração pública.
Dinamik Çok Amaçlı Eniyileme Problemleri için Hibrid Çerçevenin İncelenmesi
Authors: Kiraz Berna
Published: March 2018

Çok amaçlı evrimsel algoritmalar ve sezgisel seçen üst-sezgiseller ortamda
meydana gelebilecek farklı dinamizm tiplerini ele alan adaptif yöntemlerdir. Bu
çalışmada, bu yöntemlerin birleştirildiği yapı, dinamik çok amaçlı eniyileme
problemlerini çözmek için kullanılmıştır. Bu yapıda üst-sezgiseller toplumun
bireylerini üretecek olan sezgiselleri seçmek için kullanılır. Sezgisel seçen
üst-sezgiseller içinde kullanılan farklı sezgisel seçim yöntemlerinin etkisi
ile birlikte önerilen yaklaşımın performansı yapay olarak oluşturulmuş dinamik
test problemleri üzerinde deneysel olarak incelenmiştir. Deneysel sonuçlar öğrenme
içeren üst-sezgisellerin kullanıldığı yaklaşımın öğrenme içermeyenlere göre
daha iyi sonuç verdiğini göstermiştir. Ayrıca, önerilen yaklaşımın literatürde
iyi bilinen yöntemlerle karşılaştırıldığında rekabet edebilecek düzeyde
sonuçlar verdiği görülmüştür.
Metal Şekillendirme Proseslerinde Sac Açınım Geometrisinin Sonlu Elemanlar Yöntemi ile Geliştirilmesi
Authors: ESENER Emre , SÖNMEZ Emre , FIRAT Mehmet
Published: March 2018

Ağırlık/dayanım avantajlarından dolayı sac metal malzemeler
bir çok endüstriyel uygulamada tercih edilmektedir. Proses tasarımı, sac metal
şekillendirme yöntemleri açısından oldukça kritik bir adımdır. Sac açınım
geometrisinin belirlenmesi proses tasarımı açısından oldukça önemlidir. Optimum
açınım geometrisinin belirlenmesi ile malzeme fire miktarları önemli oranlarda
azaltılabilmektedir. Bu çalışmada kare çekme prosesi için, alüminyum 5754
alaşımı kullanılarak proses parametrelerini ve ürün geometrisini dikkate alan
sonlu elemanlar yöntemi tabanlı bir sac açınım geliştirme yöntemi sunulmuştur.
Elde edilen yeni sac açınımı ile malzeme fire miktarında önemli bir kazanç elde
edilmiş ve şekillendirilebilirlik açısından daha güvenli bir geometri
oluşturulmuştur.
O (DES)ENVOLVIMENTO EDUCACIONAL E A PROFISSIONALIZAÇÃO – UM DEBATE VICERAL PARA O COENVOLVIMENTO
Authors: Silva Rafael Santos , Souza Karine Pinheiro de Souza Pinheiro
Published: March 2018

O presente estudo apresenta uma  discussão epistemológica sobre a profissionalização da educação, contrapondo com a necessidade de formar para além de adestrar operários para o mercado. Com isso, iniciamos com um debate quantitativo e crítico com base em dados primários e secundários brasileiros referentes aos indicadores de matrícula, ao orçamento executado pelo Ministério da Educação. Com o objetivo de debater o real papel da educação como instrumento do direito social básico, especificando nosso debate sobre o processo de  (des)envolvimento da educação profissional, atrelado ao avanço da técnica pela técnica, num simples processo de industrialização da educação como corretor educativo via controle de conteúdo das determinações mercadológicas por meio da capacitação formal e não essencial. Numa abordagem crítica percebemos que o modelo de gestão se aproxima do modelo de ensino, e nos questionamos como o processo de (de)senvolvimento da educação está atrelado ao modelo de industrialização da educação? Diante desse contexto, apontamos para a força da tecnologia enquanto instrumento mobilizador de mudanças sociais quando associada ao Coenvolvimento, pode se configurar por meio de processos colaborativos e cooperativos e podem fazer emergir novas formas de aprender e ensinar rompendo com a mercantilização da Educação.
ENSINO MÉDIO NO ESTADO DO PARÁ
Authors: Ceccon Ellen Cristina
Published: March 2018

Considera-se que a transferência de recursos públicos da educação para o setor privado caracteriza-se como processos de formas de privatização da educação básica. O objetivo deste trabalho é apresentar e analisar o volume de despesas com Manutenção e Desenvolvimento do Ensino (MDE) na etapa do Ensino Médio regular (MDE-EM), empreendido pelo governo do estado do Pará no período de 2005 a 2015, focalizando os recursos contingenciados para o setor privado inscritos nas categorias econômicas 3.33.90.39 – Outros Serviços de Terceiros – Pessoa Jurídica e 3.33.50.00 – Transferências a Instituições Privadas sem fins lucrativos. Pretende-se averiguar a representatividade destes gastos no total investido em MDE no Ensino Médio para verificação do fluxo de recursos públicos transferidos para o setor privado. Para o desenvolvimento da pesquisa, realizou-se um estudo de caso, qualitativo, por meio de fontes primárias. Para análise e levantamento dos dados financeiros utilizou-se informações disponibilizadas pelo Sistema de Informações sobre Orçamentos Públicos em Educação (Siope) nos relatórios contábeis do estado do Pará. O período da pesquisa corresponde ao período histórico que compreende os anos de 2005 a 2015, pois considera-se a vigência da Lei de Responsabilidade Fiscal (Lei Complementar n. º 101/2000) que institui normas de finanças públicas relacionadas à responsabilidade na gestão fiscal. Com o estudo, observou-se que o investimento em MDE no Ensino Médio aumentou no período analisado, e que os recursos transferidos para o setor privado nessa etapa, nas categorias econômicas analisadas, oscilam, apresentando picos de elevação e recuo no estado do Pará.
RESSIGNIFICANDO OS CONCEITOS DE CRIANÇA E INFÂNCIA
Authors: De Pontes e Souza Jhaina Aryce , Mubarac Sobrinho Roberto Sanches , Herran Vallace Chriciano Souza
Published: March 2018

Este artigo busca abordar a conceituação dos termos ‘criança’ e ‘infância’ a partir de um percurso histórico, demonstrando como estes eram compreendidos e como se deu a evolução dos estudos acerca do tema até chegarmos ao momento contemporâneo. Esta pesquisa foi desenvolvida para compor a parte inicial de dissertação de mestrado com o tema “Criança: o conhecimento científico como direito na escola”, realizada durante o curso de Mestrado em Educação em Ensino de Ciências na Amazônia, na Universidade do Estado do Amazonas – UEA em 2017. A metodologia adotada foi a pesquisa bibliográfica que desencadeou a construção de revisão de literatura sobre os temas. Percebemos a dificuldade em encontrarmos conceitos claros sobre o que seria criança, bem como infância e a valorização à fase da infância como uma etapa que deve ser vivida pela criança, já que esta é um ser ativo e partícipe na construção de suas próprias culturas da infância e da construção do conhecimento.
Inherited Diseases of Holstein Cattle: Story So Far in Turkey
Authors: AVANUS Kozet , ALTINEL Ahmet
Published: March 2018

Inherited diseases are caused by recessive alleles proceed from increased inbreeding in Holstein cattle population. Bovine leucocyte adhesion deficiency (BLAD), deficiency of uridine monophosphate synthase enzyme (DUMPS), complex vertebral malformation (CVM), factor XI deficiency (FXID) and bovine citrulinaemia (BC) are the most frequent inherited diseases in Holstein cattle population. The prevalence for carriers of BLAD, DUMPS, CVM, FXID and BC diseases were reported highest in Denmark (21.5%), USA (1.2%), Japan (32.5%), Turkey (18%) and Australia (13%) respectively. Moreover the highest prevalence for carriers of BLAD, CVM and FXID were reported as 2.2%, 3.4%  and 18% respectively in Turkey so far. Neither DUMPS nor BC carriers were identified in Turkey so far. However further studies are required in order to identify the provinces that have risks for mutant alleles of inherited diseases in Turkey. Determining the carrier animals and exclude them from breeding is the only solution for eradication studies of inherited diseases.
Malignant hyperthermia in dogs during general anaesthesia
Authors: GÜZEL Özlem , ŞADALAK MCKİNSTRY Defne
Published: March 2018

Malignant hyperthermia is a pharmacogenetic disorder of skeletal muscles developing as a hypermetabolic response to inhalation anaesthetics such as halothane, sevoflurane or isoflurane and depolarizing muscle relaxants such as succinylcholine. It is produced by mutation of the RYR1 gene in dogs. In anaesthetised dogs, regardless of the anaesthetic drugs used, calcium ion channel activity may change and malignant hyperthermia may develop. Clinical features are hyperthermia, tachypne, hypercarbia, increased oxygen consumption, severe metabolic acidosis, hyperkalemia, cardiac arrhytmias and muscle rigidity. For a diagnosis of malignant hyperthermia to be made, at least 3 of the clinical findings must be determined. Dantrolene sodium is specific antagonist of malignant hyperthermia. However, it is not usually preferred by veterinary practitioners due to its high cost as well as the low incidence of the occurence of this complication. Therefore it is useful for alternative drugs such as acepromazine, diazepam and alfentanil to be used for the treatment of clinical findings manifested during malignant hyperthermia. The purpose of this review is to share with colleagues the latest information regarding the treatment of canine malignant hyperthermia occurring in relation to general anaesthesia.
BİR İLETİŞİM BİÇİMİ OLARAK EVLİLİĞİN KÜLTÜREL, SİYASİ VE EKONOMİK UNSURLARI (GİRESUN ÖRNEĞİ)
Authors: GÜLTEPE Mustafa , ÖZKAN Selfiye
Published: March 2018

Kültür, bireyin içinde yaşadığı
toplumun, inançları, değerleri, ekonomik siyasal düşünüşlerini de kapsayan bir
olgudur. Bu nedenle Levi-Strauss,  kültürün uygar ya da barbar şeklinde
tanımlanmasına karşı çıkmaktadır. Ona göre her kültür pratiğinin ait olduğu
toplumda bir işlevi bulunmaktadır. Bu bağlamda kültür bireylerin ya da
grupların tarihsel, ekonomik, sosyal ilişkilerini düzenleyen kurallar
bütünüdür. Levi-Strauss “Akrabalık İlişkileri” adlı çalışması kapsamında
evliliğin farklı boyutları incelenmeye çalışılmıştır. Bu çalışmada
Levi-Strauss’un bu eserinden yola çıkılarak Giresun ilinde yaşayan 80 yaş üstü
bireylerle görüşülerek evlilik ilişkilerinin iletişimsel, kültürel, ekonomik ve
siyasi boyutları araştırılmıştır. Araştırmada veri toplama aracı olarak görüşme
tekniğinden yararlanılmıştır. Elde edilen veriler içerik analizi yöntemi
kapsamında kodlama tekniği ile çözümlenmiştir. Kültürel bir unsur olarak
evliliğin gerçekleşme sürecinde ne gibi uygulamalar olduğuna değinilerek bu
uygulamaların işlevleri üzerinde durulacaktır.
SİYASİ ALANDA DEMOKRATİKLEŞME HAREKETLERİNİN TOPLUMSAL ALANDAKİ REALİTESİ (1808 – 1908)
Authors: AGAHABALAEI FANID Nematollah , YILMAZER Derya
Published: March 2018

Demokratikleşme sürecine Avrupa’ya
göre çok geç başlayan Osmanlı Devletinde demokratikleşme çabaları toplumsal
alanda yeteri kadar karşılığını bulamamış ve demokrasi kavramı halk için fazla
bir anlam ifade etmemiştir. Osmanlı devleti için demokratikleşme azınlıkları
devlet bünyesinde tutabilmek, dağılmayı engellemek için bir çare olarak
düşünülmüş ve genelde dış baskılar sonucu iç sorunların çözümü için bir araç
olarak kullanılmıştır. Tanzimat Döneminde aydın bir sınıfın oluşması basın yolu
ile kamuoyu yaratma çabaları umut verici olsa da Tanzime ve Islahat Fermanları
halk hareketlerinin değil saray bürokrasisinin çabaları sonucunda
gerçekleşmiştir. Halk hukuksal olarak kendisine verilen hakların çoğu zaman
farkına bile varmamıştır. Demokratik düşüncenin zayıf başarısı   Kanun-i Esasi ile iki aşamalı da olsa bir
seçim sisteminin getirilmesidir. Fakat hemen ardından otuz yıl sürecek bir
istibdat yaşanması meşruti yönetimin halk tarafından benimsenmediğini gösterir.
İncelenen yüz yıllık sürecin en önemli sonucu 1908’de Anayasanın tekrar ilan
edilmesi ve 1909 değişiklikleridir. Milli Mücadeleyi gerçekleştiren ve
Cumhuriyeti kuran kadro bu süreçte yetişmiştir.
Patronazgo y poder en la Castilla del siglo XVII: el patronato sobre el convento de las Dominicas de la Encarnación Villanueva de los Infantes), 1602-1660
Authors: Sánchez Molina Carlos
Published: March 2018

El ejercicio del patronato sobre una comunidad conventual fue uno de los privilegios a los que aspiraron la nobleza titulada y los poderosos en España durante la Edad Moderna. Se trataba de crear una Corte terrenal, un lugar de propaganda y exhibición del linaje, el poder y la preeminencia, además de expresión de la piedad nobiliaria. El poderoso de Villanueva de los Infantes (Ciudad Real), Don Francisco Fernández Buenache, regidor y alguacil mayor de Montiel, se apropió del patronazgo sobre la iglesia de las Dominicas de la Encarnación, amparándose en la necesidad que tenía el cenobio de una iglesia digna para la liturgia y la crisis que padecía Castilla a mediados del siglo XVII.
El camarín del santuario de Nuestra Señora de la Carrasca de Villahermosa (Ciudad Real): Historia, Arte y devoción
Authors: Calamardo Murat Javier
Published: March 2018

El objeto del presente trabajo es estudiar desde un punto de vista histórico y artístico el camarín del santuario de Nuestra Señora de la Carrasca de Villahermosa (Ciudad Real). Se trata de una pequeña estancia creada a finales del siglo XVII, cuyas pinturas murales conforman un ciclo iconográfico mariano que sirve de marco a la talla de la Virgen. No obstante, la decoración actual de este camarín dista de ser la original, configurándose lo que hoy en día podemos ver a lo largo de los siglos.
Factors Affecting the Efficiency of Inventory Management of Janapriya Multiple Campus, Pokhara
Authors: Bhandari Hari Bahadur
Published: March 2018

Each and every organization needs inventories to perform day to day activities to achieve set objectives. This study entitled 'factors affecting the efficiency of inventory management of janapriya multiple campus, pokhara' is to assess the factors that affect on inventory management of the campus. Basically, the study is based on primary data including 21 sample out of total population 28. Stratified random sampling is used to select a sample size of 21 respondents. Structured questionnaire and other official documents are used to collect data from primary sources. Samples were three groups of office staff. Group wise distribution of sample was top level, middle level and assistant level. The collected data are tabulated and presented according to the needs and objectives of the study. Descriptive statistics of mean and standard deviation were used for data analysis. Factors related with proper record keeping of inventory, financial resources, skill possessed by store staff and bureaucratic procurement procedure positively affect on the effectiveness of inventory management. Proper inventory record, stock information and competent & qualified store employees are very important for the effectiveness of inventory management. Sufficient fund, skillful store clerks, training and development for store staff, few quality suppliers and easy process of budget release are inevitable for superior inventory management. Janapriya Journal of Interdisciplinary Studies, Vol. 6 (December 2017), page: 78-87
Social Relationship at Workplace and Emotional Attachment of Employees: An Evidence of Pokhara Based Development Bank
Authors: Adhikari Nabin Bahadur
Published: March 2018

Effective social relationship at workplace and the emotional attachment is must for the survivable and betterment of the organization. This research paper aims to investigate employee social relationship at work and their emotional attachment with organization. For this regard hypothesis were set to test under some constraints. The study applied empirical approach in which a survey questionnaire was used to collect quantitative data and other statistical techniques like Chi square test, Pearson correlation was applied and conclude that employee commitment towards organization has some relationship to the social relationship at workplace. Additionally, the level of job involvement is associated with social relationship at workplace. Employee who is highly involved in job may not have the same proportion of level of social relationship at workplace.Janapriya Journal of Interdisciplinary Studies, Vol. 6 (December 2017), page: 88-96
Normative human brain volume growth
Authors: Peterson Mallory , Warf Benjamin C. , Schiff Steven J.
Published: March 2018

OBJECTIVE

While there is a long history of interest in measuring brain growth, as of yet there is no definitive model for normative human brain volume growth. The goal of this study was to analyze a variety of candidate models for such growth and select the model that provides the most statistically applicable fit. The authors sought to optimize clinically applicable growth charts that would facilitate improved treatment and predictive management for conditions such as hydrocephalus.

METHODS

The Weibull, two-term power law, West ontogenic, and Gompertz models were chosen as potential models. Normative brain volume data were compiled from the NIH MRI repository, and the data were fit using a nonlinear least squares regression algorithm. Appropriate statistical measures were analyzed for each model, and the best model was characterized with prediction bound curves to provide percentile estimates for clinical use.

RESULTS

Each model curve fit and the corresponding statistics were presented and analyzed. The Weibull fit had the best statistical results for both males and females, while the two-term power law generated the worst scores. The statistical measures and goodness of fit parameters for each model were provided to assure reproducibility.

CONCLUSIONS

The authors identified the Weibull model as the most effective growth curve fit for both males and females. Clinically usable growth charts were developed and provided to facilitate further clinical study of brain volume growth in conditions such as hydrocephalus. The authors note that the homogenous population from which the normative MRI data were compiled limits the study. Gaining a better understanding of the dynamics that underlie childhood brain growth would yield more predictive growth curves and improved neurosurgical management of hydrocephalus.
Early postnatal cranial vault reduction and fixation surgery for severe hydrocephalic macrocephaly
Authors: Iyer Rajiv R. , Carey Carolyn M. , Rottgers S. Alex , Tetreault Lisa , Shimony Nir , Katzenstein Jennifer , Ruas Ernesto , Tuite Gerald F.
Published: March 2018

OBJECTIVE

Infants with severe hydrocephalus and extreme macrocephaly typically undergo CSF diversion early in life, which can result in significant cranial deformity due to CSF overdrainage. In this scenario, overlap of the cranial plates can precede the development of secondary synostosis and/or severe, permanent cranial deformity. As a result, extensive cranial vault remodeling is sometimes undertaken later in life, which is often challenging and has been associated with mortality and a high morbidity rate. The authors have previously described a technique for early postnatal cranial vault reduction and fixation (CVRF), in which the calvarial bones are stabilized using absorbable fixation plates in the neonatal period, in an attempt to facilitate patient positioning, simplify hydrocephalus management, and improve cosmesis. Here, the authors describe their institutional experience managing patients with extreme neonatal hydrocephalus with CSF diversion, with and without CVRF, over the past 12 years.

METHODS

The authors retrospectively reviewed the charts of infants with extreme hydrocephalus (head circumference > 49 cm) treated at their children’s hospital with ventriculoperitoneal shunting, with or without CVRF, between 2005 and 2017. Data collected included age, sex, etiology of hydrocephalus, type of CVRF performed (anterior, posterior, or combined), follow-up duration, orbitofrontal circumference, craniometric measurements, intraoperative blood loss, operative duration, and postoperative complications. Developmental data were collected using the third edition of the Ages and Stages Questionnaire. Photographic imaging was used to demonstrate esthetic outcomes, and family questionnaires were used to evaluate satisfaction with the esthetic outcome.

RESULTS

Eleven patients with extreme neonatal hydrocephalus underwent CSF shunting; 5 underwent shunting alone and 6 patients underwent shunting and CVRF. For patients who underwent shunting and CVRF, the median age at CVRF was 6 days and the median interval between shunt placement and CVRF was 2.5 days. The mean extent of calvarial vault volume reduction was 44.5% (± 3.9%). The mean duration of the CVRF procedure was 108 minutes, and 5 of 6 patients required intraoperative transfusion. Of the 5 patients who underwent shunting alone, 3 developed severe cranial deformities. Of 6 patients who underwent shunting and CVRF, 1 had a poor cosmetic outcome. In the shunting-alone group, 2 patients died and 1 required extensive cranial vault correction at 10 years of age. One patient in the shunting and CVRF group also died.

CONCLUSIONS

CVRF in combination with CSF shunting in the neonatal period can simplify the treatment of the rare case of severe hydrocephalic macrocephaly and leads to cosmetic outcomes that are considered good by their families.
MynxGrip vascular closure device use in pediatric neurointerventional procedures
Authors: Shokuhfar Tahaamin , Hurley Michael C. , Al-Smadi Anas , Ansari Sameer A. , Potts Matthew B. , Jahromi Babak S. , Alden Tord D. , Shaibani Ali
Published: March 2018

OBJECTIVE

The aim of this paper was assess the efficacy and safety of using the MynxGrip arterial closure device in pediatric neuroendovascular procedures where the use of closure devices remains off-label despite their validation and widespread use in adults.

METHODS

A retrospective review of all pediatric patients who underwent diagnostic or interventional neuroendovascular procedures at the authors’ institution was performed. MynxGrip use was predicated by an adequate depth of subcutaneous tissue and common femoral artery (CFA) diameter. Patients remained on supine bedrest for 2 hours after diagnostic procedures and for 3 hours after therapeutic procedures. Patient demographics, procedural details, hemostasis status, and complications were recorded.

RESULTS

Over 36 months, 83 MynxGrip devices were deployed in 53 patients (23 male and 30 female patients; mean age 14 years) who underwent neuroendovascular procedures. The right-side CFA was the main point of access for most procedures. The mean CFA diameter was 6.24 mm and ranged from 4 mm to 8.5 mm. Diagnostic angiography comprised 46% of the procedures. A single device failure occurred without any sequelae; the device was extracted, and hemostasis was achieved by manual compression with the placement of a Safeguard compression device. No other immediate or delayed major complications were recorded.

CONCLUSIONS

MynxGrip can be used safely in the pediatric population for effective hemostasis and has the advantage of earlier mobilization.