bluuebunny/crossref_metadata_2025 huggingface dataset:
Remembering Jerome and Forgetting Zwingli: The Zurich Latin Bible of 1543 and the Establishment of Heinrich Bullinger’s Church
Authors: Gordon Bruce
Published: September 2024

In 1543 the Zurich reformers produced Latin translations of the Old Testament and the Apocrypha together with a revised edition of Erasmus' New Testament. The Biblia sacrosancta was a beautiful volume, Froschauer’s finest work. The work on the Old Testament was primarily done by Leo Jud, though it was completed by Theodor Bibliander and Konrad Pellikan after his death in 1542. The translation, together with the textual apparati, and the extensive prefaces form the most complete expression of the theological and ecclesiastical vision of the Zurich church under Heinrich Bullinger. Printed twelve years after the death of Huldrych Zwingli, the Bible embodied the ideals of a restored church that had to turn its back on its fallen founder. Zwingli was never mentioned and the model for a new, proud, and confident church was St Jerome, represented in the figure of the translator Leo Jud. This essay explores the relationship between biblical interpretation, identity, and church building for the second generation of the Reformation.
Biblical and Theological Themes in Heinrich Bullinger’s "De Testamento" (1534)
Authors: Mock Joe
Published: September 2024

De testamento is a both theological and a historically biblical treatise in which Bullinger discusses themes such as, for example, justification by faith, God’s accommodation to mankind, the covenant as the subject or focus of all Scripture, the covenant with Adam, the unity of the Old and New Testaments, the seed of Abraham, the covenant and right living, the Holy Spirit and covenant, the Law and covenant, the conditions of covenant, the ceremonies of covenant and the sacrament of the covenant. Far from being a work that only focuses on the covenant De testamento reveals Bullinger as a biblical theologian who is committed to challenge the elect to live integer before the sovereign El Shaddai. An examination of the Latin terms for "covenant" (foedus, testamentum and pactum) reveals that, for Bullinger, the terms are interchangeable. However, he avoids using pactum lest pactum theology be read into his work. His use of the terms are more consistent than that of Zwingli which indicates a measure of independence from Zwingli in his understanding of the covenant.
Alfred Ehrensperger, Der Gottesdienst in Stadt und Landschaft Bern im 16. und 17. Jahrhundert, 2011
Authors: Baumann Michael
Published: September 2024

No abstract available.
Michael Diller, Augustinerprior und evangelischer Prediger in Speyer, als Geächteter in Straßburg bei Bucer (1548/49) und als "Interimsflüchtling" in Basel (1549-1552)
Authors: Jenny Beat Rudolf , Bodenmann Reinhard
Published: September 2024

Michael Diller, the Augustinian prior in Speyer, was something of an anomaly amongst the reformers of the Imperial cities in the south and southwest of the Empire. That difference stemmed in part from the particular status of Speyer within the Empire, and in part from Diller's own reticence and controversy-averse personality. Additionally, we know remarkably little of Diller’s background (he came from the diocese of Speyer) and of his education (he matriculated in Wittenberg in 1523); we remain uncertain about exactly when and where he entered the order. Diller is also unusual in that he retained his position as prior up until his banishment from Speyer. He proved particular effective as an evangelical preacher precisely because of his irreproachable behavior as an Augustinian monk. This study fills in some of the gaps in our knowledge of Diller’s life after 1548 and brings clarity to numerous ambiguities. We are now aware that in spring 1549, before fleeing to Basel, Diller found refuge for several months in Strasbourg with Martin Bucer (and Conrad Hubert) and he self-identified as Bucer's pupil by that date at the latest. This relationship explains why in 1552, on being appointed as court preacher by Otto Henry, Count Palatine of Palatinate-Neuburg, he had in his possession a manuscript of Bucer and why he recommended Bucer's writings be published, although not without reservation. And, finally, we now also know the dates of his involvement in the small town of Laufen, in the territory of Basel, and have evidence for the first time that while in Laufen he was married, as had become common amongst preachers; his wife was the widow of his predecessor.
Matthias Freudenberg, Aleida Siller (Hg.), Was ist dein einiger Trost? Der Heidelberger Katechismus in der Urfassung, 2012 – Matthias Freudenberg (Hg.), Heidelberger Katechismus-Brevier, 2012 – Paolo Ricca, La fede cristiana evangelica: Un commento al Cat
Authors: Campi Emidio
Published: September 2024

No abstract available.
Luca Baschera, Tugend und Rechtfertigung, 2008
Authors: Frank Günter
Published: September 2024

No abstract available
Fritz Blanke – Lehrer und Forscher: Vortrag an der Mitgliederversammlung des Zwinglivereins 2012
Authors: Jehle Frank
Published: September 2024

In this address to the Zwingli Society in Zurich, Fritz Blanke (1900–1967) is remembered as a teacher and scholar, who educated several generations of Reformed theologians and historians, and set new standards for research as editor and commentator of Johann Georg Hamann and Huldrych Zwingli. Blanke made text come to life and reveal its relevance with utmost care and high erudition. It was essential to him that the text was elucidated whilst his personal ideas remained in the background. For this reason, his commentaries will remain indispensable.
Karine Crousaz, L’Académie de Lausanne entre humanisme et Réforme (ca. 1537–1560), 2012
Authors: Bodenmann Reinhard
Published: September 2024

No abstract available.
Heiko A. Oberman, John Calvin and the Reformation of the Refugees, 2009
Authors: Balserak Jon
Published: September 2024

No abstract available.
Pierre Viret et la diffusion de la Réforme, hg. von Karine Crousaz und Daniela Solfaroli Camillocci, 2014
Authors: Mazaheri John H.
Published: September 2024

No abstract available.
Amy Nelson Burnett, Karlstadt and the Origins of the Eucharistic Controversy, 2011
Authors: Bürki Silvianne
Published: September 2024

No abstract available.
Calvin und Reformiertentum in Ungarn und Siebenbürgen, hg. von Márta Fata und Anton Schindling, 2010
Authors: Bryner Erich
Published: September 2024

No abstract available.
Lavaters Rezeption von Spaldings "Ueber die Nutzbarkeit des Predigtamtes" und Herders "An Prediger" in seiner Predigtreihe zur Apokalypse
Authors: Kohler Daniela
Published: September 2024

After Joachim Spalding's oeuvre, "Ueber die Nutzbarkeit des Predigtamtes" was published in 1722, Johann Caspar Lavater challenged Spalding's view of the duties and benefits of the clerical minister. Above all, Lavater criticized Spalding’s focus on the moral aspects of religion, arguing that Spalding failed to concentrate on the true center – Christ and all Christian dogma. Lavater felt that Johann Gottfried Herder had furnished a better interpretation of ministerial responsibilities in "An Prediger. Funfzehn Provinzialblätter" (1774). Intrigued by Herder's proclamation of the evangelical Christ, Lavater thought that he had found support for his own Christianity in Herder. His assumption was destroyed by Herder’s work on the Apocalypse in "Maran Atha" (1779). In accordance, Lavater in his sermons about the Book of Revelation sought to provide an example, not only of how to understand the last book of the New Testament, but also by emphasizing where a minister should focus his attention in order to function as a prophet of the evangelical Jesus.
Jahresbericht des Zwinglivereins
Authors: Senn Matthias
Published: September 2024

No abstract available
Heinrich Bullinger: De scripturae sanctae authoritate, 2009
Authors: Burnett Amy Nelson
Published: September 2024

No abstract available
Urs B. Leu et al., Conrad Gessner’s Private Library, 2008
Authors: Moser Christian
Published: September 2024

No abstract available
Zur Dynamik der frühen Reformbewegung in Graubünden: Staats-, kirchen- und privatrechtliche Erlasse des Dreibündestaates 1523-1526
Authors: Bundi Martin
Published: September 2024

The article concerns a series of legal decrees made between 1523 and 1526 by the three free states of Churrätien – today the region of Graubünden. Influenced by the early reform movement these legal decisions affected both church and private law, and vestrymen were instrumental in creating them. At the same time, the representatives also constructed a new Federal Charter to replace the older and less cohesive alliance with a federation. The proclamation of faith from 1526 stands as one of the greatest achievements from this period because it gave each individual the freedom to choose between the Roman and the Reformed faith.
Calvin and His Influence, ed. Irena Backus and Philip Benedict, 2011
Authors: Giselbrecht Rebecca A.
Published: September 2024

No abstract available.
Jan Loop, Johann Heinrich Hottinger, 2013
Authors: Baschera Luca
Published: September 2024

No abstract available.
Kaspar Bütikofer, Der frühe Zürcher Pietismus (1689–1721), 2009
Authors: Seidel J. Jürgen
Published: September 2024

No abstract available.
Heike Bock, Konversionen in der frühneuzeitlichen Eidgenossenschaft, 2009
Authors: Mühling Andreas
Published: September 2024

No abstract available.
Bullingers Familiengeschichte: Edition und Kommentar
Authors: Stettler Bernhard
Published: September 2024

Annotated edition of the family history of Heinrich Bullinger with introduction,glossary and index. In 1568, Bullinger looks back and recalls his family’s history. His immediate relatives are introduced with many enlightening details, those of the inlaws only in list form. The events are committed to God’s grace. Bullinger, member of a family long-established in the town of Bremgarten in Aargau, finds his way to Zurich during the turbulences of the Reformation. His rise to become the successor of the reformer Huldrych Zwingli is experienced as God-decreed, and he and his descendants are able to integrate seamlessly into the leading elites of Zurich.
Randolph C. Head, Jenatschs Axt: Soziale Grenzen, Identität und Mythos in der Epoche des Dreissigjährigen Krieges, 2012
Authors: Bernhard Jan Andrea
Published: September 2024

No abstract available.
Jon Balserak, John Calvin as Sixteenth-Century Prophet, 2014
Authors: West Jim
Published: September 2024

No abstract available.
Girolamo Zanchi: De religione christiana fides – Confession of Christian Religion, hg. von Luca Baschera und Christian Moser, 2007
Authors: Beck Andreas J.
Published: September 2024

No abstract available.
Robert M. Kingdon mit Thomas A. Lambert, Reforming Geneva, 2012
Authors: Wildt Kees de
Published: September 2024

No abstract available.
Consensus Tigurinus (1549), hg. von Emidio Campi und Ruedi Reich, 2009
Authors: Burnett Amy Nelson
Published: September 2024

No abstract available.
The Myth of the Reformation, hg. von Peter Opitz, 2013
Authors: West Jim
Published: September 2024

No abstract available.
Christian Moser, Theodor Bibliander: Annotierte Bibliographie der gedruckten Werke, 2009
Authors: Bodenmann Reinhard
Published: September 2024

No abstract available.
"Ecclesia semper reformanda": Metamorphosen einer altehrwürdigen Formel
Authors: Campi Emidio
Published: September 2024

The purpose of this essay is to examine the history of the old formula ecclesia semper reformanda that is the church is always in need of reform. This phrase is constantly attributed to the Reformers, but in fact can be found throughout the bimillenial history of Christianity, from the early monastic movement to the medieval forms of dissent, in the documents of the Council of Trent and in the treaties of the Protestant Orthodoxy, in the decree on ecumenism of the II Vatican Council and in the Constitution of the World Alliance of Reformed Churches. However, Reform of the church is not mere change, and certainly not »modernization«. Reform of the church comes, as the Reformers understood it and Karl Barth in the mid 20th century reiterated it, from the leading of God’s word, made present in the power of the Spirit. After rewiewing recent deliberations of ecumenical bodies the paper concludes that ecclesia semper reformanda is much more than a confessional slogan. To be really universal the church is always to be refocused on Christ the Saviour as he is presented to us in the Scriptures.
Helmut Meyer/Bernhard Schneider, Mission und Diakonie: Die Geschichte der Evangelischen Gesellschaft des Kantons Zürich, 2011
Authors: Gebhard Rudolf
Published: September 2024

No abstract available.
Christoph Möhl, Fritz Blanke, 2011
Authors: Meyer Helmut
Published: September 2024

No abstract available.
Reformationsmandat für den Thurgau 1530
Authors: Wälchli Philipp
Published: September 2024

In 1530, Philipp Brunner, the governor in the dependent territory of Thurgau enacted a church ordinance introducing reform. Brunner did so by consent of Zurich, which was one of the governing states. However, the strong opposition of the other governing states, resting Catholic, made the ordinance ineffective, for the most part, and Thurgau remained bi-confessional. A short analysis of this church ordinance, critically edited here for the first time, is astonishing because only six of thirteen chapters are derived from the fundamental church ordinance of Zurich, enacted in 1530, while seven are excerpts of the Basle church ordinance of 1529. Since Zurich did not have a church ordinance covering all matters of interest, but Basle did, the two primary church ordinances from both cities were combined. Thus, the Thurgau Church Ordinance of 1530 is an early and important testimony to the effects and reception of the church ordinances from both cities.
Premisas para el análisis de los valores liberadores en las leyes de educación
Authors: López García Torres Rocío , Saneleuterio Elia
Published: September 2024

La actual Ley Orgánica 3/2020, de 29 de diciembre, por la que se modifica la Ley Orgánica 2/2006, de 3 de mayo, de Educación (LOMLOE) ha supuesto un debate crítico en nuestro país, que alude a ciertas limita- ciones en la libertad. Este artículo pretende establecer y discutir las premi- sas sobre las cuales poder realizar un análisis del concepto de la libertad y las oportunidades para su ejercicio contenidos tanto en la LOMLOE como en cualquier marco normativo educativo. El objetivo es concretar y discutir sobre los valores liberadores que, según la legislación educativa, alcanzará el alumnado a su paso por las diversas enseñanzas del sistema educativo. Para ello, la metodología propuesta es la del análisis de contenido axiológico. Los valores resultantes se presentan agrupados en: autonomía personal, esfuerzo, hábitos y disciplina, criterio propio, elección y decisión, autonomía pedagógica, organizativa y de gestión y sociedad libre. Constituyen el ejercicio responsable de la libertad, que exige un largo proceso formativo que las leyes educativas han de garantizar.
Las virtudes personales del docente en el contexto educativo actual
Authors: Vilarroig Martín Jaime , Monfort Prades Juan M.
Published: September 2024

El profesor es un elemento fundamental en todo el proceso educativo. En el actual contexto de desorientación pedagógica por la abru- madora presencia de innovaciones, conviene no olvidar los planteamientos más clásicos que ponen en el centro a la persona y la educación en virtudes. Reconocidos expertos nacionales e internacionales nos invitan a ello. La vir- tud es un hábito operativo bueno y cierto término medio entre dos extremos: esto hace que la ética de las virtudes sea más coherente con el personalismo que otras propuestas, como la ética del deber, de las consecuencias o de los valores. El docente debe ser prudente, justo, fuerte y moderado porque estas son no solo las virtudes que lo hacen mejor persona, sino también las que lo convierten en mejor docente. Además, son las virtudes en las que debe educar al alumnado. Podemos añadir a estas virtudes clásicas las virtudes teologales leídas en clave personalista: el maestro debe creer en, esperar en y amar al alumno que le ha sido confiado.
Solidarity with Creation and Human Rights: Discovering the Lost Foundation
Authors: Taylor Michael Dominic
Published: September 2024

A true sense of solidarity played a crucial role in counteringCommunism’s denial of the unalienable dignity of the human person froma non-antagonistic position based in the universal message of the Gospel.Pope John Paul II, through the Thomistic Personalism that was fundamentalto the Universal Declaration of Human Rights, fought tirelessly to reinstatethe pre-political truth of this dignity throughout the West. However, afterthe fall of the Berlin Wall, in the face of a persistent materialism, his focusbroadened to include a deeper consideration and stronger defense of the entire created order. Solidarity with creation speaks to the ontological covenantthat undergirds the dignity of the human person and calls him or her to atemporal and eschatological responsibility for the created world that “waitswith eager longing for the revealing of the sons of God” (Rm 8, 19). A deeperappreciation of and commitment to the metaphysical truths of reality implicit in solidarity with creation –participation, communion, and self-donation are necessary for the health of our natural world as well as the health of ourhuman communities and our democracies.
The Scene of the Crime: October 9th, Maspero, and Egyptian Journalism after the Revolution
Authors: Chammah Maurice
Published: September 2024

On October 9, 2011, violence broke out in front of the Maspero building in downtown Cairo, turning a peaceful march into clashes that resulted in the deaths of over twenty protesters. Immediately, accusations targeted the state-owned media, claiming that it had reverted to Mubarak-era practices of provoking inter-religious violence and had failed to acknowledge the possibility that the military had purposefully killed protesters. While covering the story, independent journalists found themselves working out their relationship to activists as they tried to build a credible case against the state-sanctioned version of the events. This is the story of the march, its aftermath, and the way it was covered, along with brief forays into the history of Egyptian media, offering a broad look at Egyptian journalism a year after Mubarak’s fall from power.
Private Satellite Channels in Egypt: The Relationship between Ownership and Editorial Policy
Authors: Nasser Mohamed
Published: September 2024

Many observers say that the Egyptian media, both state-owned and private, are on the front lines of the crisis Egypt has been going through since the fall of the old regime, because, in spite of repeated demands for restructuring state-owned radio and television, the old status quo is still entrenched.[1] In fact, the revival of the post of information minister in itself and the selection of a minister who is close to the establishment confirms that the mentality for dealing with the state-owned media remains as it was—that is, to make sure that the media owned by the people remains under the control of the regime, whatever the regime might be. This crisis in the state-owned media, with all its negative effects, is relatively modest compared with the chaos and deliberate anarchy that prevail in the private satellite media, which many people believe is seriously attempting to contain the Egyptian revolution and gradually empty it of content.
Al Jazeera Television: Rhetoric of Deflection
Authors: Al-Sadi Mahmoud R.
Published: September 2024

Some media scholars and commentators argue that Al Jazeera is radicalizing Arab audiences; others argue that the channel is moderating the beliefs of both the Arab public and Arab regimes. A third group of scholars and commentators argues that Al Jazeera, despite its identification with the Arab masses, is still in line with other official mass media, whose primary objective is to advance and defend the interests of the host government. To contribute to the ongoing debate over Al Jazeera, and to help situate Al Jazeera more accurately in the matrix of Arab mass media, I offer a close reading of the channel’s political discourse on issues that sharply divide the Arab public from the Qatari government and other Arab regimes. The evidence emerging from textual analysis of the channel’s political discourse indicates that identification between the channel and the majority of the Arab masses does not signal a substantive, liberational rhetoric. Rather, identification signals a widely used rhetorical strategy that allows Al Jazeera to ultimately deflect the viewers’ radicalism and channel it towards nonviolent political ideologies that are conducive to Qatari interests and policies. Furthermore, by indirectly connecting Qatar with the anti-establishment viewers, Al Jazeera reinvents Qatari autocracy, depicting it as an acceptable form of governance.
Remembering Anthony Shadid’s Craft and Conscience
Authors: Khouri Rami G.
Published: September 2024

The many deserved accolades and tributes to the late New York Times correspondent Anthony Shadid after his death in February were moving testaments to his life and work.[1] It was hard to count the many ways in which his friends and colleagues—and thousands of readers who never knew him personally—emphasized the special, even unique, aspects of his personal and professional lives. It is fitting to recall those two dimensions of his life, but also perhaps to wonder if we who are left behind can make a greater effort to go beyond merely recalling what made him special, to reach the point where his now widely noted special qualities might infuse the work and attitudes of those thousands of journalists who still deal with the Middle East and the Arab world, as writers, editors, reporters and producers.
Embracing AI in Change Management
Authors: Westover Jonathan
Published: September 2024

Abstract: This article discusses how organizations can leverage artificial intelligence (AI) to support rather than hinder change management efforts amid technological transformation. It first establishes a research foundation on common sources of resistance to change, such as job insecurity, lack of understanding, and lack of involvement. The article then presents examples of how AI can augment traditional change management approaches to systematically address each resistance factor. Specifically, AI enhances two-way communication through personalized outreach and question answering. It also enables immersive, dynamic training solutions for ubiquitous, experiential skill development. AI fosters wider participation and feedback while monitoring employee well-being and performance. By addressing causes of resistance at each stage, AI strengthens critical aspects of communication, education, participation, and support to build understanding of changes rather than apathy. The article argues leaders who view AI as an ally in change management will empower their workforce through disruption.
Melestarikan Budaya Kinang Dalam Menjaga Kesehatan Gigi dan Mulut di Desa Paku Alam Kota Banjarmasin Timur
Authors: Rahman Subhannur , Siti Nurhaliza  , Syrly Syrly , Fitriani Elisa , Susan Pradini Raihana , Kurnia Wina
Published: September 2024

Kebiasaan mengunyah sirih sekarang ini sudah jarang atau bahkan ada yang tidak pernah mendengar istilah “nginang”. Aktivitas nginang merupakan aktivitas warisan leluhur yang sudah sangat langka dan hampir punah di Banjarmasin. Peminatnya sangat sedikit dan hanya dilakukan oleh orang-orang tertentu saja. Pengabdian masyarakat ini dilakukan di salah satu desa daerah Banjarmasin Timur. Kegiatan dilakukan menggunakan metode ceramah, diskusi dan latihan. Pengabdian Masyarakat ini menggunakan 12 informan. Informan yang dipilih adalah informan yang masih mengunyah sirih pinang ketika wawancara dilakukan. Hasil pengabdian menunjukkan bahwa masyarakat disana mengalami peningkatan kebiasaan mengunyah sirih pinang, yang ditandai dengan kondisi giginya sangatlah bagus. Rata-rata masyarakat disana yang tidak memiliki kebiasaan menginang, mengalami kerusakan pada gigi seperti adanya karies gigi, gigi yang tidak utuh lagi, dan gigi. Penemuan di lapangan menunjukkan bahwa masyarakat Desa Paku Alam kurang dalam merawat kesehatan gigi dan memicu adanya kerusakan pada gigi. Setelah dilakukan pengabdian, masyarakat disana mengalami perubahan pola pikir dan mereka memiliki keinginan yang kuat untuk menjadikan menginang sebagai kebiasaan mereka.
Manajemen Gigitan Ular Dengan Budaya Betatawar (Getah Daun Pepaya) melalui Pendekatan Culture Care
Authors: Mohtar M. Sobirin , Mahmudah Rifa'atul , Ariani Malisa , Riyanti Dewi , Erianti  , Putri Nazilatul Audah Surya
Published: September 2024

Daun pepaya merupakan salah satu tanaman yang mengandung saponin. Saponin adalah salah satu senyawa yang memacu dalam pembentukan suatu kolagen, yaitu suatu protein struktur yang berperan dalam proses penyembuhan luka. Senyawa ini merupakan salah satu senyawa flavonoid yang larut dalam air serta dapat diekstrakkan menggunakan etanol 70% Berdasarkan data Lokakarya Nasional Tanaman Obat pada tahun 2010, dari total 40.000 jenis tumbuhan di dunia, Indonesia telah memiliki 30.000 jenis tumbuhan termasuk di antaranya 940 jenis tumbuhan yang berkhasiat sebagai obat. Pepaya (Carica papaya L.) adalah tanaman yang berkhasiat sebagai obat. Salah satu bagian dari tanaman pepaya yang berkhasiat sebagai obat ialah daunnya. Daun Carica papaya merupakan salah satu tanaman yang mengandung saponin, sedangkan kulit batang dan akar dari Carica papaya mengandung flavonoid dan alkaloid, selain itu juga daun serta akarnya mengandung polifenol dan bijinya mengandung saponin. Polifenol dan flavonoid memiliki aktivitas yaitu sebagai antiseptic. Pengobatan tradisional adalah pengobatan atau perawatan menggunakan cara maupun obat – obat atau ramuan tradisional yang mengacu pada pengalaman, keterampilan turun temurun dan diterapkan sesuai norma–norma yang berlaku dalam masyarakat Salah satunya getah daun pepaya sebagai pengobatan tradisional pada gigitan ular.
Epigenetic Modifications as Predictive Biomarkers for Cardiovascular Disease: A Longitudinal Study on DNA Methylation Patterns and Disease Risk
Authors: Burhanuddin M.A.
Published: September 2024

Cardiovascular disease (CVD) is a leading cause of death worldwide, and early detection and prevention are essential to reduce its burden. Although traditional risk factors such as hypertension and lipid levels are standard predictors, they tend to identify the risk of disease at a later date There is an urgent need to develop more accurate, leading-edge biomarkers indicating molecular changes that occur before the onset of clinical symptoms. Epigenetic changes, in particular DNA methylation, provide a promising approach to identify individuals at risk for CVD. Despite advances in understanding the genetic underpinnings of CVD, little is known about how dynamic epigenetic modifications influenced by environmental and lifestyle factors can serve as early predictive biomarkers the risk of the disease. This study aims to address this gap by investigating whether DNA methylation patterns can predict future CVD risk before clinical manifestations. The primary objective of this study was to systematically investigate the association between DNA methylation patterns and CVD risk. Specifically, the study seeks to identify regions where DNA methylation changes are associated with cardiovascular outcomes and investigate the predictive potential of these epigenetic changes for future disease. 1,000 participants aged 30-75 years were followed for 5 to 10 years. Periodic blood samples were collected for DNA methylation analysis by bisulfite sequencing and microarrays. Major CVD risk factors such as adiposity, hypertension and smoking status were also controlled. Comprehensive statistical models were used to assess the association between DNA methylation changes and CVD incidence. Participants who developed CVD showed significant differences in DNA methylation in regions associated with lipid metabolism (e.g., APOA5) and inflammation (e.g., TNF-α) Over time, those who developed heart disease and vascular events revealed progressive hyper methylation of key genes, with 85% sensitivity 78 to predict future CVD risk % and specificity skin. These methylation patterns were discovered years before the appearance of conventional clinical pathology. This study shows that DNA methylation patterns are determinants of acute cardiovascular risk, providing a novel approach for early detection and prevention The findings suggest the inclusion of epigenetic biomarkers in routine risk assessment about may improve the identification of individuals at high risk for CVD It is important to inform individuals at high risk of CVD of the diagnosis and to explore possible interventions that can alter change a occurs in this epigenetic and reduced CVD risk.
Engineering Bioartificial Liver Constructs Using 3D Bioprinting and Stem Cell Technology: Addressing Organ Shortages for Transplantation
Authors: Li Xiang , Pan Haoyuan , Yao Jianlin
Published: September 2024

The global shortage of donor liver transplants poses a significant challenge to healthcare systems, with thousands of patients dying each year while on waiting lists This study examines the potential of technological liver transplantation 3D bioprinting and advanced stem cell technologies serve as solutions to address this important issue The goal was to create functional liver tissues that are complex structures of the natural liver and some of the important functions, and assess its viability as an alternative organ donor includes hepatocytes and other liver-specific cell types with an optimal pro-mesenchymal differentiation pattern stem cells ( MSCs). Experimental results indicated that these compounds could perform important hepatic functions such as hepatic metabolism, urea synthesis, pharmacokinetics, under in vitro and in vivo conditions in addition to promising a have been carried out with foreign tissues through pre-testing in animal models and showed that although further improvements are needed, especially in improving tissues and ensuring long-term function, findings in this review represents a significant step toward the development of bioartificial livers as alternatives to conventional liver transplantation.
Learning Readiness Profile of 10th Grade SMK Students in Civic Education with Social-Emotional Worksheets
Authors: Thoriq Abdul Aziz  , Arini Fathia Handayani
Published: September 2024

This study aims to analyze the learning readiness profile of 10th-grade students at SMK Negeri 5 Garut in Civic Education (Civic Education) lessons facilitated by social-emotional worksheets (LKPD) A quantitative descriptive method was employed, involving the distribution of social-emotional student worksheet and a Google Form questionnaire to 36 students. The results reveal that 73.8% of students exhibit a medium to high level of learning readiness in Civic Education. These findings indicate that the integration of Social Emotional Learning (SEL) approaches within student worksheet contributes positively to the enhancement of students' affective aspects and civic dispositions, which are essential goals of Civic Education. Furthermore, these results suggest the potential of SEL-based student worksheet in facilitating character development aligned with the Profil Pelajar Pancasila, particularly in the dimensions of independence, critical thinking, and collaboration.
Pelatihan IPTEK dan Pengenalan Aplikasi E-Commerce Kepada Guru Madrasah Ad-diniyyah, Kampung Tipar, Jakarta Timur
Authors: Novianti Eva , Astuty Eka Yuni , Ayu Susilawati Endang , Syamsiyah Nur , Febriana Sesunan Mira
Published: September 2024

Pengabdian kepada masyarakat merupakan bentuk penerapan ilmu pengetahuan, teknologi, dan seni budaya secara langsung kepada masyarakat melalui institusi pendidikan dengan menggunakan pendekatan ilmiah sebagai bagian dari pelaksanaan Tri Dharma Perguruan Tinggi. Program pengabdian ini didanai oleh universitas melalui proses seleksi proposal yang ketat. Kegiatan dengan judul “Pelatihan IPTEK dan Pengenalan Aplikasi E-Commerce kepada Guru Madrasah Ad-diniyyah, Kampung Tipar, Jakarta Timur” bertujuan untuk meningkatkan kompetensi para guru melalui pelatihan IPTEK dan memperkenalkan E-Commerce sebagai platform jual beli online untuk membantu memasarkan produk kreatif Madrasah. Pelatihan IPTEK dilakukan dengan menggunakan aplikasi seperti Word dan Excel, yang bertujuan memudahkan peserta dalam kegiatan administratif serta meningkatkan keterampilan mereka. Pengenalan E-Commerce dilakukan melalui marketplace Indonesia seperti Lazada, meliputi proses pembuatan akun, pembuatan email, pembukaan toko online, serta teknik pemasaran dan transaksi produk. Metode pelatihan dilakukan melalui demonstrasi yang disampaikan oleh instruktur, kemudian diikuti dengan latihan bagi peserta untuk mempraktikkan materi yang telah diberikan. Meskipun program ini berjalan sesuai rencana dan berhasil dilaksanakan dengan baik, terdapat beberapa peserta yang belum sepenuhnya menguasai materi yang disampaikan, yang disebabkan oleh keterbatasan waktu yang tersedia.
Cultural historical research in support of inclusive classrooms:
Authors: Stepaniuk Inna , Ferholt Beth
Published: September 2024

This article showcases the potential of dialogue within cultural historical research (CHR) to enhance our understanding of and advocacy for inclusivity in schools. It illustrates how the authors, each rooted in distinct subfields – cultural historical activity theory (CHAT) and romantic science – employ a unique approach to knowledge production regarding inclusive classrooms. By refraining from the pursuit of agreement and instead fostering an environment where their studies are juxtaposed, the authors engage in what they term “inclusive coauthoring,” approaching each other’s methodologies with an asset-based, solidarity-seeking stance. The first author utilizes excerpts from an ethnographic study in an elementary classroom to demonstrate how CHAT can elucidate the intricate dynamics of diverse classrooms, shedding light on mechanisms of inclusion/exclusion and identifying potential barriers (opportunities) to inclusive practices. On the other hand, the second author illustrates how a romantic science perspective can empower educators to cultivate inclusivity in ways previously unexplored before their deep engagement with the study. Uniting in collaboration around shared goals rather than shared methods, led the authors to unforeseen advancements, particularly in one of the studies.
Redes sociales, turismofobia y vivienda
Authors: San Cornelio Gemma
Published: September 2024

Los meses de verano conllevan las vacaciones y, por lo tanto, la proliferación de viajes y turismo en general. Por gracia de los algoritmos que gobiernan las redes sociales y sus cámaras de resonancia, durante las últimas semanas he recibido una serie de anuncios y sugerencias de cuentas a seguir que muestran dos caras de la vivienda turística y sus manifestaciones en forma comunicativa.
Optimization of conditions to achieve a high content of alizarin and purpurin in the adventitious roots of Rubia cordifolia L.
Authors: Gnanaraj Muniraj , Sundaram Bhagavathi  Sivamaruthi , Mohamed Sulaiman Sheik , Sisubalan Natarajan , Ghouse Basha Mohamed Hussain , Chaiyasut Chaiyavat
Published: September 2024

Rubia cordifolia L. (Indian madder) is a valuable medicinal plant known for its natural dye content, notably alizarin and purpurin, with applications in textiles and cosmetics. This study aims to optimize the concentrations of auxin, salicylic acid, elicitors, and precursors to maximize the production of alizarin and purpurin in adventitious roots. Various concentrations and combinations of auxins were systematically tested to explore their effects on the yield of adventitious root formation and dye compounds. Nodal explants cultivated in MS media supplemented with IAA + IBA + NAA (1.5 + 0.5 + 0.75 mg/L) at a pH of 5.7 exhibited the highest adventitious root production. Post-establishment of root cultures, the impact of salicylic acid, L-phenylalanine, elicitors (yeast extract, pectin, and Xylan), and the precursor α-ketoglutaric acid on the production of anthraquinones (AQ) was evaluated. High-performance liquid Chromatography (HPLC) analysis revealed enriched alizarin, purpurin, and total AQ content. The maximum amount of AQ (64.65 mg/g), alizarin (17.59 mg/g), and purpurin (19.61 mg/g) was observed when cultured on 30 mg/L of α-ketoglutaric acid, compared to other elicitors and precursors. This optimized condition provides valuable insights for the sustainable cultivation and utilization of R. cordifolia as a prominent source of natural dyes. It offers practical implications for the dye industry and its production.
Review of the hyperfine structure theory of hydrogen molecular ions
Authors: Zhong Zhen-Xiang ,   Theoretical Physics Research Center, School of Physics and Optoelectronic Engineering, Hainan University, Haikou 570228, China,   Department of Theory and Interdisciplinary Research, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China
Published: September 2024

The study of high-precision spectroscopy for hydrogen molecular ions enables the determination of fundamental constants, such as the proton-to-electron mass ratio, the deuteron-to-electron mass ratio, the Rydberg constant, and the charge radii of proton and deuteron. This can be accomplished through a combination of high precision experimental measurements and theoretical calculations. The spectroscopy of hydrogen molecular ions reveals abundant hyperfine splittings, necessitating not only an understanding of rovibrational transition frequencies but also a thorough grasp of hyperfine structure theory to extract meaningful physical information from the spectra. This article reviews the history of experiments and theories related to the spectroscopy of hydrogen molecular ions, with a particular focus on the theory of hyperfine structure. As far back as the second half of the last century, the hyperfine structure of hydrogen molecular ions was described by a comprehensive theory based on its leading-order term, known as the Breit-Pauli Hamiltonian. Thanks to the advancements in non-relativistic quantum electrodynamics (NRQED) at the beginning of this century, a systematic development of next-to-leading-order theory for hyperfine structure has been achieved and applied to \begin{document}$\text{H}_2^+$\end{document} and \begin{document}$\text{HD}^+$\end{document} in recent years, including the establishment of the \begin{document}$m\alpha^7\ln(\alpha)$\end{document} order correction. For the hyperfine structure of \begin{document}$\text{H}_2^+$\end{document}, theoretical calculations show good agreement with experimental measurements after decades of work. However, for HD+, discrepancies have been observed between measurements and theoretical predictions that cannot be accounted for by the theoretical uncertainty in the non-logarithmic term of the \begin{document}$m\alpha^7$\end{document} order correction. To address this issue, additional experimental measurements are needed for mutual validation, as well as independent tests of the theory, particularly regarding the non-logarithmic term of the \begin{document}$m\alpha^7$\end{document} order correction.
Cell crowding induces TRPV4 inhibition and its relocation to plasma membranes, implicating pro-invasive cell volume reduction mechanotransduction pathway
Authors: Bu Xiangning , Ashby Nathanael , Vitali Teresa , Lee Sulgi , Gottumukkala Ananya , Yun Kangsun , Tabbara Sana , Latham Patricia , Teal Christine , Chung Inhee
Published: September 2024

Cell crowding is a common microenvironmental factor that affects various disease processes, but its impact on cell invasiveness into surrounding tissues is not well understood. In this study, we investigated the biomechanical changes induced by cell crowding, focusing on pro-invasive cell volume reduction. We discovered that cell crowding enhanced the invasiveness of high-grade ductal carcinoma in situ (DCIS) cells, which experienced significant cell volume reduction compared to hyperplasia-mimicking or normal cells. Mass spectrometry analyses revealed that cell crowding relocated ion channels, including TRPV4, a calcium-permeant ion channel, to the plasma membrane selectively in high-grade DCIS cells but not in less aggressive or normal cells. Cell crowding inhibited TRPV4 in high-grade DCIS cells, which led to decreased intracellular calcium levels and subsequent volume reduction. TRPV4 inhibition also prompted relocation of TRPV4 to the plasma membrane. This relocation primed inactive TRPV4 for activation, effectively counterbalancing the calcium loss from crowding-induced channel inhibition. Analyses of patient-derived breast cancer tissues validated that TRPV4 selectively associated with the plasma membrane in high-grade DCIS but not in lower-grade DCIS or less aggressive pathologies. The extent of plasma membrane TRPV4 association scaled with cell volume reduction and increased cell invasiveness and motility, suggesting its utility as an active pro-invasive mechanotransduction pathway indicator. Additionally, hyperosmotic conditions and pharmacologic TRPV4 inhibition mimicked the pro-invasive volume reduction observed under cell crowding, while TRPV4 activation reversed this effect by inducing cell volume increase. In summary, our study reveals a previously unrecognized pro-invasive mechanotransduction pathway triggered by cell crowding, which is selective in high-grade DCIS cells. This discovery offers new biophysical perspectives on cell invasiveness, highlighting the critical role of a selective mechanotransduction mechanism in the progression of breast cancer cells that are considered non-invasive but associated with high risk.
Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease
Authors: Homan Edwin A , Gilani Ankit , Rubio-Navarro Alfonso , Johnson Maya , Cortada Eric , Pereira de Lima Renan , Stoll Lisa , Lo James C
Published: September 2024

Together with obesity and type 2 diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global epidemic. Activation of the complement system and infiltration of macrophages has been linked to progression of metabolic liver disease. The role of complement receptors in macrophage activation and recruitment in MASLD remains poorly understood. In human and mouse,
C3AR1
in the iver is expressed primarily in Kupffer cells, but is downregulated in humans with MASLD compared to obese controls. To test the role of complement 3a receptor (C3aR1) on macrophages and liver resident macrophages in MASLD, we generated mice deficient in C3aR1 on all macrophages (C3aR1-MφKO) or specifically in liver Kupffer cells (C3aR1-KpKO) and subjected them to a model of metabolic steatotic liver disease. We show that macrophages account for the vast majority of
C3ar1
expression in the liver. Overall, C3aR1-MφKO and C3aR1-KpKO mice have similar body weight gain without significant alterations in glucose homeostasis, hepatic steatosis and fibrosis, compared to controls on a MASLD-inducing diet. This study demonstrates that C3aR1 deletion in macrophages or Kupffer cells, the predominant liver cell type expressing
C3aR1
, has no significant effect on liver steatosis, inflammation or fibrosis in a dietary MASLD model.
A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model
Authors: Sugimoto Mitsuru , Takagi Tadayuki , Suzuki Tomohiro , Shimizu Hiroshi , Shibukawa Goro , Nakajima Yuki , Takeda Yutaro , Noguchi Yuki , Kobayashi Reiko , Imamura Hidemichi , Asama Hiroyuki , Konno Naoki , Waragai Yuichi , Akatsuka Hidenobu , Suzuki Rei , Hikichi Takuto , Ohira Hiromasa
Published: September 2024

Background:

Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed to establish a simple PEP risk score model (SuPER model: Support for PEP Reduction) that can be applied before ERCP.

Methods:

This multicenter study enrolled 2074 patients who underwent ERCP. Among them, 1037 patients each were randomly assigned to the development and validation cohorts. In the development cohort, the risk score model for predicting PEP was established via logistic regression analysis. In the validation cohort, the performance of the model was assessed.

Results:

In the development cohort, five PEP risk factors that could be identified before ERCP were extracted and assigned weights according to their respective regression coefficients: –2 points for pancreatic calcification, 1 point for female sex, and 2 points for intraductal papillary mucinous neoplasm, a native papilla of Vater, or the pancreatic duct procedures (treated as ‘planned pancreatic duct procedures’ for calculating the score before ERCP). The PEP occurrence rate was 0% among low-risk patients (≤0 points), 5.5% among moderate-risk patients (1–3 points), and 20.2% among high-risk patients (4–7 points). In the validation cohort, the C statistic of the risk score model was 0.71 (95% CI 0.64–0.78), which was considered acceptable. The PEP risk classification (low, moderate, and high) was a significant predictive factor for PEP that was independent of intraprocedural PEP risk factors (precut sphincterotomy and inadvertent pancreatic duct cannulation) (OR 4.2, 95% CI 2.8–6.3; p<0.01).

Conclusions:

The PEP risk score allows an estimation of the risk of PEP prior to ERCP, regardless of whether the patient has undergone pancreatic duct procedures. This simple risk model, consisting of only five items, may aid in predicting and explaining the risk of PEP before ERCP and in preventing PEP by allowing selection of the appropriate expert endoscopist and useful PEP prophylaxes.

Funding:

No external funding was received for this work.
Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent
Authors: Lejeune Alannah , Zhou Chunyi , Ercelen Defne , Putzel Gregory , Yao Xiaomin , Guy Alyson R , Pawline Miranda , Podkowik Magdalena , Pironti Alejandro , Torres Victor J , Shopsin Bo , Cadwell Ken
Published: September 2024

Gastrointestinal (GI) colonization by methicillin-resistant Staphylococcus aureus (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune and microbial factors that permit GI colonization remain unknown. Male sex is correlated with enhanced Staphylococcus aureus nasal carriage, skin and soft tissue infections, and bacterial sepsis. Here, we established a mouse model of sexual dimorphism during GI colonization by MRSA. Our results show that in contrast to male mice that were susceptible to persistent colonization, female mice rapidly cleared MRSA from the GI tract following oral inoculation in a manner dependent on the gut microbiota. This colonization resistance displayed by female mice was mediated by an increase in IL-17A+ CD4+ T cells (Th17) and dependent on neutrophils. Ovariectomy of female mice increased MRSA burden, but hormonally female mice that have the Y chromosome retained enhanced Th17 responses and colonization resistance. Our study reveals a novel intersection between sex and gut microbiota underlying colonization resistance against a major widespread pathogen.