bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in Bone Quality after Treatment with Etelcalcetide
Authors: Khairallah Pascale , Cherasard Jenna , Sung Joshua , Agarwal Sanchita , Aponte Maria Alejandra , Bucovsky Mariana , Fusaro Maria , Silberzweig Jeffrey , Frumkin Gail N. , El Hachem Karim , Schulman Linda , McMahon Donald , Allen Matthew R. , Metzger Corinne E. , Surowiec Rachel K. , Wallace Joseph , Nickolas Thomas L.
Published: August 2023

Introduction

Secondary hyperparathyroidism is associated with osteoporosis and fractures. Etelcalcetide is an intravenous calcimimetic for the control of hyperparathyroidism in patients on hemodialysis. Effects of etelcalcetide on the skeleton are unknown.

Methods

In a single-arm, open-label, 36-week prospective trial, we hypothesized that etelcalcetide improves bone quality and strength without damaging bone–tissue quality. Participants were 18 years or older, on hemodialysis ≥1 year, without calcimimetic exposure within 12 weeks of enrollment. We measured pretreatment and post-treatment areal bone mineral density by dual-energy X-ray absorptiometry, central skeleton trabecular microarchitecture by trabecular bone score, and peripheral skeleton volumetric bone density, geometry, microarchitecture, and estimated strength by high-resolution peripheral quantitative computed tomography. Bone–tissue quality was assessed using quadruple-label bone biopsy in a subset of patients. Paired t tests were used in our analysis.

Results

Twenty-two participants were enrolled; 13 completed follow-up (mean±SD age 51±14 years, 53% male, and 15% White). Five underwent bone biopsy (mean±SD age 52±16 years and 80% female). Over 36 weeks, parathyroid hormone levels declined 67%±9% (P < 0.001); areal bone mineral density at the spine, femoral neck, and total hip increased 3%±1%, 7%±2%, and 3%±1%, respectively (P < 0.05); spine trabecular bone score increased 10%±2% (P < 0.001); and radius stiffness and failure load trended to a 7%±4% (P = 0.05) and 6%±4% increase (P = 0.06), respectively. Bone biopsy demonstrated a decreased bone formation rate (mean difference −25±4 µm3/µm2 per year; P < 0.01).

Conclusions

Treatment with etelcalcetide for 36 weeks was associated with improvements in central skeleton areal bone mineral density and trabecular quality and lowered bone turnover without affecting bone material properties.

Clinical Trial registry name and registration number:

The Effect of Etelcalcetide on CKD-MBD (Parsabiv-MBD), NCT03960437
Peritoneal Dialysis–Related Infections
Authors: Cho Yeoungjee , Chow Kai-Ming , Kam-Tao Li Philip , Runnegar Naomi , Johnson David W.
Published: August 2023

Peritoneal dialysis (PD) represents an important treatment choice for patients with kidney failure. It allows them to dialyze outside the hospital setting, facilitating enhanced opportunities to participate in life-related activities, flexibility in schedules, time and cost savings from reduced travel to dialysis centers, and improved quality of life. Despite its numerous advantages, PD utilization has been static or diminishing in parts of the world. PD-related infection, such as peritonitis, exit-site infection, or tunnel infection, is a major concern for patients, caregivers, and health professionals—which may result in hesitation to consider this as treatment or to cease therapy when these complications take place. In this review, the definition, epidemiology, risk factors, prevention, and treatment of PD-related infection on the basis of the contemporary evidence will be described.
Competitive Team-Based Learning and Teachers’ and Students’ Resposiblities
Authors: Hassan Hosseini Seyed Mohammad
Published: August 2023

The present article brings to the fore teachers’ as well as students’ responsibilities in my innovative approach to teaching, Competitive Team Based Learning (CTBL), situations. Some of ver high significant guidelines and hints have been provided for more effective (language) learning and teaching via CTBL. These noteworthy guidelines and hints would be of immense help to educators, for more effective (language) teaching via my instructional approach. The paper also elaborates the initial process I went through in the course of developing my seminal approach based on my own edu-political theories. (Hosseini, 2023) This would, I hope, give teachers a sence of how they can contribute to the development and to the quality of their teaching.
Methods Analysis: Comparing Competitive Team-Based Learning with other Instructional Methods and Approaches
Authors: Hassan Hosseini Seyed Mohammad
Published: August 2023

Having introduced Competetive Team Based Learning (CTBL), my innovative approach to teaching, this paper presents a cogent and critical analysis and comparison of CTBL with other popular methods /approaches in the arena of Education in general and Language Teaching in particular, in terms of their distinguishing features and characteristics. Among such methods and approaches are Communicative Language Teaching (CLT), Collaborative Learning (ColL), Interactive Learning (IntL), and Cooperative Learning (CL) methods which are appreciated particularly in the U.S. and in the West. A synthesis of the distinguishing drawbacks of the comparison methods and approaches is part of the article. The chapter also explicates how CTBL, my educational innovation, that has been formulated based on my edu-political theories (Hosseini, 2023) is, in the last analysis, an approach to human security and prosperity and world peace. I hope this chapter would contribute to making a sound decision on implementing CTBL in the arena of (Language) Education for the ultimate goal of peace making and more compassionate civilizations building.
Netaji's Armed Struggle in Southeast Asia and the Ina Trials
Authors: Aamresh Aamresh , Meena Dr. Rajesh Kumar
Published: August 2023

This study examines the years from 1943 to 1946 with regards to the activities of Bose. The study also analyses the extraordinary place of Bose among Indian revolutionaries and the characteristics that set him apart from his kindred revolutionaries which allowed him to single-handedly create a "Free India" movement in Occupied Europe and Southeast Asia. The reshaping of Indian National Army by Bose and the internal dynamics and limitations of the movements that Bose headed with Japanese collaboration is also examined. This study critically examines the job of Bose in taking over the Andaman and Nicobar Islands and the degree of achievement of his visit to Andaman as the head of Andaman and Nicobar Islands. The points of interest of Bose's strategies for alliances, armed struggles and revolting against the British are critically analyzed. The study also takes a gander at how the INC saw the activities of Bose and the Free India struggle during the war and how it used the countrywide turmoil in favor of Bose during the INA Officers Trial of 1945 for their own closures. The study finishes up by looking at how the British saw Bose during this period, the precautions they took against the Indian National Army and the impact of the INA Officers Trial of 1945.
Comparative Effect of Faradic and Russian Currents on the Quadriceps Muscle in Patients with Knee Osteoarthritis
Authors: Rani Neha , Verma Sonam , Das Karishma , Pramanick Palas , Chauhan Komal
Published: August 2023

Abstract: Osteoarthritis is amongst the most common musculoskeletal condition which affects overall function and quality of life in the Indian population. Clinical features of knee osteoarthritis include pain that affects the functional mobility of joints and thus interferes with walking and activities of daily living. Quadriceps function declines with age, and is further impaired in patients with knee and may contribute to the risk of falls. The aim of the present study was to compare the effect of Faradic and Russian Currents on the quadriceps muscle in Patients with knee osteoarthritis. Objectives: To evaluate the effect of Faradic Currants on the quadriceps muscle for the management ofknee osteoarthritis. To evaluate the effects of Russian Currants on the quadriceps muscle for t h e management of knee osteoarthritis. To Comparative effects between Faradic and Russian Currants on the quadriceps muscle formanagement of knee osteoarthritis. Methodology: Permission from the head of the department of Sanskriti University Mathura, and approval from the ethical committee. Patients pre-diagnosed with grade II OA were selected for this study. Consent was taken from the patients after confirming the diagnosis of Grade II OA. The subjects were divided into two groups (15 in each group): one group consist of a Faradic current + quadriceps isometric exercise (5 days a week for 4 weeks) and the second group consisted of a Russian current + quadriceps isometric exercise (5 days in a week for 4 weeks). Result: The statistics a r e done based on the objectives and hypotheses and it has been organized by following three sections: Section I: Frequency and percentage distributions of socio-demographic variables.Section II: Effectiveness of pre and post-test values. Section III: Comparison of Faradic Currants and Russian Currants Values. Conclusion: This study concludes that faradic current and Russian current show significant effect in quadriceps muscle in patients with knee osteoarthritis and there is no significant difference between faradic and Russian current on quadriceps muscle Patients with knee osteoarthritis.But the only significant difference in WOMAC scores after intervention (The WOMAC score ismore decreased in Russian as compared to faradic current)
Humedales costeros en mares interiores de Isla Grande de Chiloé y Golfo de Reloncaví, Región de Los Lagos, Chile: comparación de flora, vegetación y degradación antrópica
Authors:   Pontificia Universidad Católica de Chile, Ramírez Carlos , Pérez Yessica ,   Universidad Austral de Chile, Montaña Alvaro , San Martín Cristina ,   Pontificia Universidad Católica de Chile, Vidal Osvaldo , Valenzuela Jorge ,   Instituto de La Patagonia, Universidad de Magallanes
Published: August 2023

Con metodologías de sistemática tradicional, fitosociológica y estadística multivariada se comparó la flora y la vegetación de tres humedales costeros de mares interiores: Huildad y Putemum en la isla grande de Chiloé y Quillaipe en el Golfo de Reloncaví, en la Región de Los Lagos, en el Sur de Chile. La flora total de ellos está formada por 91 especies de las cuales, 75 son nativas y 16 introducidas. También a ella pertenecen 62 Dicotiledóneas, 20 Monocotiledóneas y 9 Pteridófitos. En el espectro biológico dominan plantas leñosas y hierbas perennes. Cincuenta y seis especies son terrestres, 26 palustres, 5 epifíticas, 2 psamófitas y 3 plantas acuáticas (hidrófitos). Setenta especies son de ambientes no salinos, 16 son halófilos y 5 indiferentes. Helechos se encontraron sólo en Chiloé, con una mayor extensión de vegetación boscosa. Las especies nativas disminuyen de sur a norte y las introducidas de norte a sur, de la misma manera se comportan las plantas leñosas y las hierbas perennes. Sólo en Quillaipe abundaron los helófitos (plantas palustres) y caméfitos de marismas. Se presentó una correlación negativa entre número de habitantes de la ciudad más cercana con el número de especies presentes. La similitud florística entre humedales es muy baja. Se distinguieron 5 formaciones vegetales: bosques, matorrales, praderas, arroyos dulciacuícolas y marismas. En los tres humedales se presentaron en total 16 asociaciones vegetales de las cuales sólo 2 son comunes a ellos, por lo que también se presentó baja similitud vegetacional. Once asociaciones son primarias, 4 secundarias y 1 terciaria (matorral de Ulex europaeus). En general, los humedales estudiados son menos diversos en flora y vegetación que los del mar abierto y de más al norte, en Chile.
POSITIVES AND NEGATIVES OF GLOBALIZATION IN THE ARABIC LANGUAGE
Authors: Akmal Fajri  , Zulhelmi Anshar
Published: August 2023

Globalilasi yang terjadi membawakan perubahan dalam budaya, politik, ekonomi, dan teknologi. Sehingga terjadinya era globalisasi tidak dapat dihindari oleh setiap lapisan masyarakat, negara, dan bangsa di dunia ini, khususnya bagi negara arab. Globalisasi yang membawa perkembangan teknologi informasi dan komunikasi tentu memberikan dampak terhadap bahasa dalam hal ini bahasa arab. Sebagaimana yang kita ketahui bahwa bahasa merupakan budaya dan juga alat komunikasi yang digunakan dalam masyarakat. Sedangkan globalisasi yang terjadi membawa perubahan yang sangat besar dalam budaya tentu saja dalam hal ini juga meberikan dampak bagi bahasa arab yang merupakan objek dalam penelitian pada artikel ini. Setiap dampak yang diberikan globalisasi selalu terdiri dari nilai positif dan nilai negatif. Kedua nilai ini yaitu positif dan negatif tidak dapat kita hindari dari penilai terhadap dampak yang diberikan oleh globalisai. Nilai positif yang diterima selau dipadang sebagai hal yang bagus sedangkan nilai negatif  adalah sebaliknya yaitu memiliki hal buruk yang diterima. Dalam artikel ini penulis ingin melihat dampak dari nilai positif dan negatif yang didapatkan oleh bahasa arab dari globalisasi. Dengan mengunakan metode analisis deksritif dan kajian pustakan dalam pengumpulan data. Dimana bahan-bahan diambil dari artikel-artikel jurnal ilmiah dan buku-buku yang membahas tentang globalisai terhadap bahasa arab dan juga nilai positif dan negatif dari globalisai pada bahasa arab.
VERBAL AGGRESSION ON SOCIAL MEDIA INSTAGRAM AND POLITICAL DISENGAGEMENT ON VOTERS IN INDONESIA
Authors: Qurratuain Luthfiyah , Syaiful Irfan Aulia , Umam Ahmad Naufalul
Published: August 2023

Penelitian ini bertujuan untuk melihat pengaruh agresi verbal terhadap political disengagement pada Pemilih Pemula. Penelitian ini memiliki desain penelitian kuasi eksperimen. Partisipan penelitian ini adalah 152 mahasiswa (18 yang secara acak dikelompokkan menjadi kelompok eksperimen dan kontrol dengan teknik matching dan random assignment. Partisipan kelompok eksperimen mendapatkan perlakuan untuk melihat unggahan foto mengandung agresi verbal di Instagram sedangkan partisipan kelompok kontrol tidak mendapat perlakuan apapun. Hasil penelitian menunjukkan adanya perbedaan signifikan political disengagement partisipan, di mana partisipan yang terpapar dengan konten agresi verbal di kelompok eksperimen menunjukkan kadar political disengagement yang lebih tinggi daripada yang tidak terpapar dikelompok kontrol (t=2.23 , p=.027). Studi ini dapat menjadi langkah awal pemahaman terhadap agresi verbal di media sosial dan ketidak terikatan terhadap politik terhadap pemilih di Indonesia.
Chromosome-scale genome assembly and conservation genomics reveals purifying selection and adaptation in a critically endangered bird
Authors: Zheng Chenqing , Chen Qing , Huang Shiguo , Chen Guoling , Song Weizhen , Lin Hongzhou , Xu Chunsheng , Qian Xiran , Cheng Yachang , Jiang Aiwu , Fan Zhongyong , Liu Yang
Published: August 2023

The effective purging of deleterious mutations in small populations can
alleviate inbreeding depression caused by historical bottlenecks.
However, how evolutionary history and adaptation have influenced the
genetic load and genomic make-up in small populations remains
contentious. Here, we evaluated the genetic consequences of long-term
severe bottlenecks on genetic diversity, genetic load, and adaptation by
a critically endangered nocturnal species, the White-eared Night-Heron
Gorsachius magnificus (GOM). We assembled a chromosome-scale
genome of GOM and applied several conservation genomic analyses on
multiple individuals of GOM and its closely related Black-crowned
Night-heron Nycticorax nycticorax (NYN). Our analyses revealed
contrasting demographic trajectories between the two species with the
sharp population decline since the Pleistocene in GOM, whereas large and
relatively stable effective population size in NYN. The severe
population bottleneck has resulted in a lower level of genetic diversity
and a higher level of inbreeding, which further led to a greater number
of runs of homozygosity and the accumulation of deleterious mutations in
the GOM population relative to the NYN population. The deleterious
alleles with strong negative impacts were effectively purged to mitigate
the inbreeding depression during the GOM population contractions. We
also identified candidate genes under positive selection and specific
eyeball tissue that is involved in immune activity, DNA repair
functions, and visual functions, which may be related to of adaptation
lifestyle of GOM. Overall, our study sheds light on the endangerment
mechanism of an endangered species but also provides an invaluable
genomic resource for a poorly studied bird group, the Ardeidae.
Factors associated with SARS-CoV-2 symptomatic infection in university students: a school-wide web-based survey during the Omicron variant outbreak
Authors: Katahira Mai , Sameshima Hisami , Tanuma Rie , Setoyama Kumi , Yamaguchi Yuka , Kamachi Akiyo , Nakamura Satoko , Sakuma Mayuko , Kawaike Yoichi , Furuya Tamotsu , Ijichi Shinji
Published: August 2023

Background: The Omicron outbreak is characterized by breakthrough
infection and reinfection. If no strategic solution can be found,
vaccination-rate-based risk compensation may prolong the COVID-19
crisis. Infection control in university students may have an indirect
impact on the COVID-19 burden for other age groups Methods: To reveal
the association between related factors and a symptomatic episode of
COVID-19, a school-wide web-based questionnaire survey was conducted
among university students as a part of the annual health check-up in
April, 2023. The positive outcome was confined to the first symptomatic
onset during the Omicron variant outbreak. Results: In this
self-administered and non-observational survey, risk or protective
associations were merely estimated statistically in university students
(n = 5,406). In measured factors, karaoke and club/group activities
could maintain the statistical significance in adjusted odds ratios
(ORs) as (relative) risk factors, and science course, measles/rubella
(MR) vaccination, and COVID-19 vaccination remained as (relative)
protective factors in adjusted OR analyses. Club/group activities (with
member gathering) and karaoke sing-along sessions in university students
may frequently have WHO’s three Cs. These risk factors are still
important topics for the infection control of COVID-19 in university
students. Together with some recent reports from other researchers, the
significant protective role of MR vaccine in our survey warrants further
clinical investigation. Conclusions: If the breakthrough infection
continuously constitutes the majority of infection, real data in
test-negative case-control or web-based questionnaire design continue to
be important for statistical analysis to determine the minimal
requirement of our strategies which may replace COVID-19 vaccines.
Ransomware in Cybersecurity: Threat Landscape, Recent Incidents, and Mitigation Strategies
Authors: Anandhi G.
Published: August 2023

The escalating menace of ransomware attacks has emerged as a formidable
challenge within the realm of cybersecurity. This research paper
meticulously delves into the intricate evolution of ransomware threats,
underscored by their escalating frequency and severity. Recent instances
of companies falling victim to these pernicious attacks are spotlighted,
offering a sobering view of the potential consequences. With a keen
focus on deciphering the strategies and countermeasures employed to
effectively navigate and neutralize these threats, this paper assumes a
pivotal role in shedding light on the imperative need for proactive
measures. By scrutinizing the tactics harnessed by cybercriminals and
the resolute efforts mustered by organizations in their quest to
mitigate risks, this research endeavors to unravel the dynamic landscape
of ransomware threats. The synthesis of empirical case studies,
meticulous statistical analysis, and expert insights creates a
multifaceted perspective, enriching the discourse on ransomware’s
evolving nature. Consequently, the paper accentuates the pressing
importance of fostering collaborative and comprehensive cybersecurity
protocols, laying the foundation for fortifying the digital domain
against the relentless tide of ransomware incursions.
CPmatrixandCl(1,3) Algebra in Electrodynamics
Authors: Hasan Syed Najamul , Manzoor Tahir
Published: August 2023

We constructed the electromagnetic wave equation in the Dirac algebraic
system C l ( 1 , 3 ) . Then, the interpretation of Maxwell’s equations
in terms of the spectral basis defined for the algebra along with the
octonion formalism using its Fano plane concept is addressed thoroughly
Serial Document Layout Analysis Method Based on Improved Mask R-CNN Architecture
Authors: Zhang Xiaoming , Zhao Weidong , Xue Qingjun , Li Xujian , Xiao Zhiyong
Published: August 2023

Document Layout Analysis plays an important part in understanding the
content of the document and extracting OCR text. Existing methods rely
primarily on parallel analytical and identification techniques. Based on
the analysis of the advantages and disadvantages of parallel methods,
this article proposes a Serial Classification Recognition Method based
on the improved architecture of the Mask R-CNN. To be specific, an
improved feature pyramid model SCBAM-FPN is proposed, which utilizes
Spatial Attention Module and Channel Attention Module as well as Atrous
Convolution to reduce the loss of local information in feature maps and
expand the receptive field, thereby increasing the performance of FPN
express ability. Experiments show that using SCBAM-FPN to replace the
original feature pyramid network in Mask R-CNN improves the detection
performance of Mask R-CNN network for multi-scale targets. In addition,
in order to improve the accuracy of segmentation, a Mask edge correction
algorithm is proposed, which combines the FCN semantic segmentation
results with edge superpixel information and uses the Mask-IoU mechanism
to perform edge corrections on Masks with scores of less than 90%. The
serial classification recognition method utilizes the improved Mask
R-CNN architecture to perform Document Layout Analysis. Firstly, the
document image is recognized and the table is segmented. Secondly, the
image after the split table is used to identify and segment the
illustrations. Finally, identify the title and paragraph of the image
after removing the table and the illustration. Although the serial
classification and recognition method has a certain degree of decline in
speed, this method solves the problem of competition among multiple
attributes and improves the accuracy of recognition compared with
existing methods. In this article, experiments that were conducted on
three datasets show that the proposed method surpasses existing methods
in terms of accuracy and efficiency.
Western Barents Sea Circulation and Hydrography, past and present
Authors: Kolås Eivind Hugaas , Baumann Till M. , Skogseth Ragnheid , Koenig Zoe , Fer Ilker
Published: August 2023

The Barents Sea is one of the main pathways for warm and saline Atlantic
Water (AW) entering the Arctic Ocean. It is an important region for
water mass transformation and dense-water production that contribute to
the Atlantic meridional overturning circulation. Here, we present data
from three cruises and nine glider missions conducted between 2019 and
2022 in the western Barents Sea, and compare with historical data
collected from 1950 to 2009. We present circulation pathways,
hydrography, heat content and volume fluxes of Atlantic- and
Arctic-origin waters. Our observations show that 0.9±0.1 Sv (1 Sv =
10 m s) of
Atlantic-origin water reaches the Polar Front (PF) region before
splitting into several branches and eventually subducting beneath Polar
Water (PW). The observed increased heat content in the AW inflow over
the past decades can be traced under the Polar front. The amount of heat
stored in the basin north of the PF is determined by the density
difference between AW and PW, and reached a maximum in the 90s when PW
was particularly fresh. The inflow of Atlantic Water (AW) into the
Barents Sea during the period from 2019 to 2022 exhibits a decrease in
salinity of up to 0.1 g kg compared to previous
decades. Consequently, this leads to a reduction in the production of
dense water, an increased temperature gradient across the PF, and a
reduced poleward transport of warm water.
Influence of thermal ageing on tensile-plastic flow and work hardening parameters of Indian reduced activated Ferritic Martensitic steel
Authors: Sahoo K.C. , Laha K.
Published: August 2023

The present study investigates the influence of thermal ageing (873K/5000h) on the microstructure, tensile-plastic flow behavior, and work hardening parameters of normalized and tempered (N&T) 1.4W-0.06Ta Indian Reduced Activated Ferritic Martensitic (INRAFM) steel. To comprehensively understand the tensile-plastic flow response of the INRAFM steel across a broad temperature spectrum of 300-873 K, the Hollomon, Ludwigson and Voce equations were employed. The results reveal an augmentation in the strain hardening exponent following the ageing process, attributed to the heightened work hardening capability of the aged steel, while the strain hardening coefficient exhibited a decline post ageing. To elucidate the dislocation debris structure?s formation and movement within both the N&T and thermally aged specimens, transmission electron microscopy (TEM) specimens were procured in close proximity to the tensile tested specimens at varying temperatures of 300, 573 and 873 K. The tensile plastic flow behavior at diverse temperatures was aptly described by Hollomon, Ludwigson, and Voce equations. The fitting accuracy of these equations was determined using the goodness of fit, as indicated by the lowest ?2 values. The constitutive Voce equation successfully captured the yield strength (YS) and ultimate tensile strength (UTS) with the initial stress and saturation stress acting as fitting parameters. Distinct patterns of initial stress and saturation stress variations were observed concerning both N&T and aged steel in relation to temperature. Furthermore, absolute value of the Voce strain component (nv) demonstrated a reduction consequent to ageing, manifesting a two-stage behavior corresponding to temperature elevation. Notably, the deceleration of the recovery process during high temperature conditions was more pronounced in the thermally aged steel when contrasted with the N&T steel. Conclusively, the Voce relation proved efficacious in predicting the yield stress (YS) and ultimate tensile strength (UTS) of both the thermally aged and N&T INRAFM steel at varying temperatures.
Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming
Authors: Pan Xiaowen , Ye Lingxia , Guo Xiaozhen , Wang Weihua , Zhang Ziyin , Wang Qintao , Huang Jingjing , Xu Jingya , Cai Yanhan , Shou Xinxin , Wang Yuting , Feng Yu , Xie Cen , Shan Pengfei , Meng Zhuo-Xian
Published: August 2023

Thermogenic adipocytes have been extensively investigated because of their energy-dissipating property and therapeutic potential for obesity and diabetes. Besides serving as fuel sources, accumulating evidence suggests that intermediate metabolites play critical roles in multiple biological processes. However, their role in adipocyte differentiation and thermogenesis remains unexplored. Here, we report that human and mouse obesity is associated with marked downregulation of glutamine synthetase (Glul) expression and activity in thermogenic adipose tissues. Glul is robustly upregulated during brown adipocyte (BAC) differentiation and in brown adipose tissue (BAT) upon cold exposure and Cl316,243 stimulation. Further genetic, pharmacologic, or metabolic manipulations of Glul and glutamine levels reveal that glutamine cells autonomously stimulate BAC differentiation and function and BAT remodeling and improve systemic energy homeostasis in mice. Mechanistically, glutamine promotes transcriptional induction of adipogenic and thermogenic gene programs through histone modification–mediated chromatin remodeling. Among all the glutamine-regulated writer and eraser genes responsible for histone methylation and acetylation, only Prdm9, a histone lysine methyltransferase, is robustly induced during BAC differentiation. Importantly, Prdm9 inactivation by shRNA knockdown or a selective inhibitor attenuates glutamine-triggered adipogenic and thermogenic induction. Furthermore, Prdm9 gene transcription is regulated by glutamine through the recruitment of C/EBPb to its enhancer region. This work reveals glutamine as a novel activator of thermogenic adipocyte differentiation and uncovers an unexpected role of C/EBPb-Prdm9–mediated H3K4me3 and transcriptional reprogramming in adipocyte differentiation and thermogenesis.

Article Highlights
Análisis de personalidad emprendedora en agricultores del municipio de Bahía de Banderas Nayarit
Authors: Becerra Bizarrón Manuel Ernesto , Castellón Palacios Mercedes Rosario
Published: August 2023

En México, la agroindustria enfrenta problemas de baja productividad y carece de herramientas para elaborar presupuestos y costos de producción. Además, los agricultores carecen de una visión empresarial y no tienen actitudes ni personalidad emprendedora, lo que dificulta el desarrollo de un modelo de negocios. El objetivo de la investigación fue evaluar los rasgos de personalidad emprendedora en agricultores mediante un estudio cualitativo, transversal y descriptivo. Como resultado, se encontró que los rasgos de personalidad emprendedora con puntajes más altos son autoeficacia, autonomía, locus de control y optimismo. Se observaron diferencias en los rasgos de innovación y motivación por logro. De manera similar, los rasgos con puntajes más bajos, es decir, los que no se destacaron, son: innovación, que implica que el emprendedor crea ideas originales, apoya nuevas ideas, está dispuesto a aprender nuevas formas de trabajo e incorpora ideas nuevas en sus tareas; y tolerancia al estrés, que implica que el emprendedor pueda controlar sus emociones y concentrarse en situaciones estresantes, además de trabajar bajo presión.
QUALITY OF ACCOUNTING INFORMATION SYSTEMS, HR COMPETENCE AND GOVERNMENT INTERN CONTROL SYSTEM IN BELITUNG DISTRICT
Authors: Lisda Ruslina , Ari Ari anugrah
Published: August 2023

This Study aims to determine how much influence the quality of accounting information systems, human resource competencies and government internal control systems have on the performance of local government agencies. Data collection techniques were carried out through primary data with questionnaires. The population in this study were employees at the Dinas-Dinas di Pemerintah Kabupaten Belitung. The results show that partially the quality of the accounting information system affects the performance of the agency with an influence contribution of 25,1%, the competence of human resources affects the performance of the agency with a contribution of 17,3% influence, and the government’s internal control system affects the performance of the agency by influence contribution of 29%. The results of this study also show that simultaneously the quality of accounting information systems, human resource competencies and government intenral control systems have an effect on agency performance with a contribution of 71,4% influence.
DISCLOSURE OF CARBON EMISSIONS: MEDIA EXPOSURE, INDUSTRY TYPE, AND PROFITABILITY OF FOOD AND BEVERAGE COMPANIES
Authors: Asmeri Rina , Ardiany Yuli , Sari Rubianti , Suarsa Abin , Sari Lira
Published: August 2023

This study aims to determine the effect of media exposure, industry type, and profitability on the disclosure of carbon emissions in food and beverage sector manufacturing companies listed on the Indonesia Stock Exchange in 2017-2019. The type of data used in this study is quantitative data sourced from the company’s financial statements. The source of data in this study is secondary data. The population in this study is the food and beverage sector companies on the Indonesia Stock Exchange in the 2017 to 2019 period with a total of 60 companies. The sampling technique used purposive sampling technique based on predetermined criteria. Based on the predetermined criteria, a sample of 18 companies was obtained. The analytical method used in this study used logistic regression analysis. The results of this study show that, partially, media exposure has an insignificant effect on carbon emissions, industry type has a significant effect on carbon emissions, profitability has an insignificant effect on carbon emissions, and simultaneously, media exposure, industry type, and profitability have an effect on carbon emissions. The unique findings of this paper are relevant to government, management, and standard setters.
RELATIONSHIP BETWEEN INTELLECTUAL INTELLIGENCE, ADVERSITY QUOTIENT AND EMPLOYEE PERFORMANCE MEDIATED BY RELIGIOUSITY
Authors: Bachmid Sofyan , Harun Harun , Noval Noval
Published: August 2023

This article presents a novel approach to understanding the relationship between intellectual intelligence, Adversity Quotient, religiosity, and employee performance in Islamic banks. While previous research has focused on examining the individual impact of these variables on employee performance, this study explores the potential mediating effects of religiosity. The study was conducted on a sample of 141 employees at Islamic banks in Palu City, and the data were analyzed using PLS-SEM. The findings indicate that religiosity mediated the relationship between Adversity Quotient and employee performance, while the relationship between intellectual intelligence and employee performance was not mediated by religiosity. These unique findings highlight the importance for Islamic banks to provide worship facilities and hold Islamic studies to enhance employee religiosity, ultimately leading to improved performance. Overall, this study adds novelty to the literature by offering a fresh perspective on the dynamics of employee performance in the Islamic banking sector.
UNDERSTANDING HOW JOB STRESS, ACHIEVEMENT MOTIVATION, WORK DISCIPLINE, AND EMOTIONAL INTELLIGENCE IMPACT EMPLOYEE JOB SATISFACTION
Authors: Safrida Safrida , Wasesa Supar , Yudha Tri Kartika , Simbolon Ramadona
Published: August 2023

This research aims to explain the Job Stress, Achievement Motivation, Work Discipline and Emotional Intelligence on Employee Job Satisfaction at PT. Bank Maybank Indonesia Tbk. Diponegoro Center. A quantitative study using a saturation sample methodology was conducted on 56 employees, and multiple linear regression analysis and SEM PLS were used for data analysis. The results indicated that both emotional intelligence and job stress have an effect on job satisfaction, partially showing the same results, i.e., emotional intelligence partially has a positive and significant influence on job satisfaction and job stress has a positive and significant influence on job satisfaction. Using SEM-PLS produces the same result: emotional intelligence has a positive and significant influence on job satisfaction. Research results can be a company's input to improve performance with variables in research. Research only at PT. MayBank Indonesia Therefore, the data collected is limited to only one company.
Perancangan Sistem Jurnal Online Berbasis Android di Perpustakaan
Authors: Gunaidi Aang , Yoanda Sely
Published: August 2023

The development of information technology allows the development of an innovative library service system, one of which is the development of a journal management system. Research purposes to develop an android-based online journal system in library. The research method uses a prototype system development method with five stages. The results of this study succeeded in developing an android-based online journal system with several search, submit and review journal features. The results of the system testing show that the web design is attractive to users with a score of 4.0; realibility is good enough to get a mean of 3.0; (c) Responsiness is quite good with a score of 3.0; security 3.0 the system's ability to maintain user data security is good enough; Functionality is quite good with 3.0; Attractivess is very interested in the 5.0 score; Personalization 3.0, this shows that the availability of information to ask questions is good enough.
Rancang Bangun Perpustakaan Buku Digital (E-Book) Berbasis Web
Authors: Saputra Ricco Herdiyan , Waziana Winia , Baba Jimi Ali , Magribi M Ridho , Putra Aditya Dwi
Published: August 2023

One of the efforts to improve the quality of human resources is to foster interest and reading habits. For this reason, the library is expected to become a center for activities that foster interest and reading habits. Libraries have a great responsibility to increase and develop interest and enthusiasm for reading. Information and communication technology (ICT) has become a part of human life today. Therefore, all institutions are competing in the integration of ICT to build and strengthen their knowledge-based talents, to be able to compete in the global era. The need for information technology (IT) is closely related to the role of libraries as a driving force in the preservation and dissemination of scientific information, which develops along with people's activities of writing, printing, educating, and meeting their information needs. The writing of this study uses the descriptive qualitative method and STMIK Pringsewu as the object of the study. The Web-Based Digital Book Library is designed to be easily accessible to readers. Uploaded e-books are created in PDF format. The digital library system can only be accessed locally in the STMIK Pringsewu environment.
Peran Green Library dan Perpustakaan Islam dalam Pengembangan Ilmu Pengetahuan
Authors: Kesuma Aghesna Rahmatika , Rahmawati Dwi Indri , Putri Mutiara Cahyani
Published: August 2023

Human civilization is characterized by the existence of a writing culture, since the discovery of human letters began to write starting from writing using stones, leaves, palm stems and other writing lats that existed at that time. From these writings which are then stored in the library which becomes a legacy for future generations. During the classical Islamic period, libraries experienced very rapid development, starting from the many libraries that were built magnificently and equipped with adequate facilities. During the classical Islamic era there were several types of libraries, one of which was the public library. The public library itself was built to be shown to the general public around the library. Islamic libraries are very closely related to science, so libraries have an important role in the development of science, such as; as an information center or learning center, as a research center, and as a translation center. Green Library also acts as an environmentally friendly library (cool, fresh, beautiful, beautiful) which is far from damaging the environment so that learning and working activities become more comfortable and enthusiastic.
Transformasi Konsep Kegiatan Perpustakaan Berbasis Inklusi Sosila di Masa Pandemi (Studi Kasus Perpustakaan Universitas Teknokrat Indonesia)
Authors: Iqbal Rahmat , Soleha Nadya Amalia
Published: August 2023

The University Library is an integrated library of educational, research and community service activities and functions as a learning resource center to support the achievement of educational goals located in higher education. The library provides various kinds of information that can help people who do not have a job base by providing information about the job market and providing training or practice for someone to be able to become an entrepreneur. The author uses qualitative research with library research methods. In collecting data, the author makes observations, documentation and direct interviews. From the recap in January-April, it shows that there has been an increase in student interest in visiting the library, this is shown by the number that continues to increase every month. From this it can be concluded that library activities have a very effective role in attracting student visits. Therefore, it is proper for us librarians to present activities that increase knowledge and knowledge in the university environment. The increase in interest in visiting is always accompanied by interest in borrowing/reading library users.
Analisis Kebutuhan Informasi dan Ketersediaan Koleksi di Perpustakaan Fakultas Hukum Universitas Lancang Kuning
Authors: Situmeang Elfrida , Rismayeti Rismayeti , Latiar Hadira
Published: August 2023

Tujuan penelitian ini adalah untuk mengetahui tingkat ketersediaan koleksi di Perpustakaan Fakultas Hukum Universitas Lancang Kuning. Populasi dari penelitian ini sebanyak 1.610 Mahasiswa sedangkan sampel yang ada dalam penelitian ini sebanyak 95 Mahasiswa. Metode penelitian yang digunakan adalah metode deskriptif kuantitatif dengan teknik pengumpulan data observasi, kuesioner, wawancara dan dokumentasi. Hasil dari penelitian ini sebagai berikut (a) Kebutuhan Informasi mutakhir (Current Need Aproach) sebanyak 45 orang membutuhkan koleksi dari sisi keilmuan  (b) Kebutuhan informasi rutin (Everyday Need Approach) sebanyak 52 responden membutuhkan bahan informasi didalam mencari koleksi seperti hasil penelitian dosen (jurnal) dan penelitian mahasiwa (skripsi). (c) Kebutuhan informasi Mendalam (Exhaustic Need Approach)  yang paling dibutuhkan mahasiswa dalam bentuk karya cetak : (buku, majalah, laporan dan lain lain) berjumlah 65 responden.  (d) Kebutuhan informasi sekilas (Catching Up Need) yang paling dibutuhkan daftar judul koleksi baru di perlukan dalam mencari informasi sebanyak 58 respoden, sementara itu ketersediaan koleksi perpustakaan Hukum Unilak paling banyak menyediakan koleksi dari daftar  berupa buku, prosiding dan jurnal judul buku baru yang berjumlah 3.503 judul, Sehingga ketersediaan koleksi dengan kebutuhan informasi sekilas dinyatakan tersedia dari sisi daftar judul buku baru
Politics and Conflict during the Reign of Caliph Uthman ibn Affan 644-656
Authors: Rohmatillah Itsna , Setiawan Agus Mahfudin , Rifai Idris Ahmad
Published: August 2023

This study discusses Politics and Conflict in Islamic History during the reign of Usman bin Affan. Usman bin Affan's 644-656 reign is considered one of the most controversial periods in Islamic history due to the many conflicts and disagreements among political leaders at that time. The aim of this study is to understand the political background during Usman bin Affan's reign, analyze the political conflicts that occurred at that time, and evaluate the impact of these political conflicts on society at that time. This study uses historical analysis methods by examining literature and primary and secondary sources related to Islamic history during Usman bin Affan's reign 644-656 . The research findings indicate that the political conflicts during Usman bin Affan's 644-656 reign were very complex and had a broad impact on society at that time. Therefore, this research is expected to provide a deeper understanding of the political history and conflicts in Islamic history and to serve as a basis for understanding the political dynamics in the future. Additionally, the results of this study can contribute to the development of knowledge of Islamic history and serve as a reference for researchers and academics in the fields of history and Islamic politics.
Potret Kejayaan Umat Islam dalam Ilmu Agama, Falsafat dan Sains (Belajar Dari Pengalaman Abbasiyah)
Authors: Masykuroh Siti , Saputra Nurdin Andy
Published: August 2023

Mencermati rentang perguliran sejarah pada masa Abbasiyah, umat Islam tengah berada di puncak kejayaan dan memimpin peradaban dunia. Pada masa ini kedaulatan umat Islam telah sampai pada puncak kemuliaan dan kemajuan dengan lahirnya berbagai bidang ilmu pengetahuan seperti ilmu pengetahuan bidang agama, falsafat dan sains. Kemajuan ilmu pengetahuan yang dihantarkan oleh Bani Abbasiyah, sesungguhnya adalah hasil dari proses dialog yang panjang antara panggilan al-Qur’an dalam mengolah dan menata kehidupan dengan usaha mencermati dan memahami fenomena alam sekitar. Hal seperti ini tentu tidak semudah membalikkan tangan, tapi dibutuhkan semangat dan kerja keras pada setiap lapisan masyarakat. Kesemuanya dituntut bahu membahu dalam mencapai tujuan bersama.
Enhancing Mathematical Interest and Learning Outcomes: The Lift-the-flap Book Incorporating Tolaki Local Wisdom and Islamic Values
Authors: Samrin Samrin , Riansyah Firman , Patih Tandri , Tarty Indri Purnama , Nastiti Dyah Kumala
Published: August 2023

This research addresses the problem of low student interest and learning outcomes in junior high school mathematics. It aims to develop a lift-the-flap mathematics book contextualized with Tolaki local wisdom and Islamic religious values and investigate its impact on students' interest and achievement. The study was conducted following the Research and Development (RD) framework, specifically the ADDIE model comprising Analysis, Design, Development, Implementation, and Evaluation phases for instructional design. The teaching material developed was applied to a Grade VII Junior High School class focusing on numerical topics. Results from data analysis suggested that the material demonstrated a good level of feasibility, scoring 76 percent for media feasibility and 77 percent for content feasibility. Overall, the material was well received by both teachers and students, with positive response rates of 74 percent and 85 percent, respectively. Descriptive analysis indicated a notable increase of 26.43 percent in students' interest in learning mathematics following the use of the lift-the-flap book. Moreover, inferential statistics revealed a significant improvement in students' interest and learning outcomes in mathematics after the implementation of the teaching materials contextualized with Tolaki local wisdom and Islamic religious values. The improvement was statistically significant with a p-value less than 0.05, indicating that the lift-the-flap book has substantial potential in enhancing mathematics education. Based on the results, we recommend further studies to investigate the impact of such culturally-infused teaching materials on other aspects of learning, and exploration of its applicability in other educational levels or subjects.
Alıç Anacının Hafif Çukurgöbek Yenidünya Çeşidinde Vejetatif Büyüme, Çiçeklenme ve Meyve Tutumu Üzerine Etkilerinin Ön Sonuçları
Authors: POLAT Atila Aytekin
Published: August 2023

Çalışmanın amacı, alıç anacının Hafif Çukurgöbek (HÇG) yenidünya çeşidinin vejetatif büyümesi, fenolojik özellikleri, çiçeklenme ve meyve tutum oranları üzerine etkisini araştırmaktır. Çalışmada, yenidünya çöğür anacı da kontrol olarak kullanılmıştır. Anaç/çeşit kombinasyonlarının, vejetatif büyümesi (anaç ve gövde çapı, yıllık sürgün uzunluğu) çiçeklenme dönemleri (çiçeklenme başlangıcı, ilk çiçeklenme, tam çiçeklenme, çiçeklenme sonu ve meyve tutumu tarihleri) ile çiçek salkım özellikleri (salkım uzunluğu, salkımdaki somak, çiçek tomurcuğu ve açan çiçek sayıları ile salkımdaki tutan ve derimi yapılan meyve sayıları) incelenmiştir. Ayrıca, anaçlara göre çiçeklenme ve meyve tutum oranları belirlenmiştir. Tüm çiçeklenme dönemleri, alıç anacı üzerindeki bitkilerde, yenidünya çöğür anacından daha erken meydana gelmiştir. Alıç anacına aşılı olan bitkiler, yenidünya anacına aşılı olanlara göre meyve deriminde iki gün erkencilik sağlamıştır. Gerek salkım uzunluğu gerek salkımın öteki özellikleri bakımından anacı yenidünya çöğürü olan bitkiler, alıç anacına aşılı bitkilere göre daha yüksek değerler verirken, küçük meyve ve derimi yapılan meyve sayısı bakımından alıç anacına aşılı bitkiler, daha iyi sonuçlar vermiştir. Anacı alıç olan bitkilerin çiçeklenme oranı (%93.52) anacı yenidünya çöğürü (%89.00) olanlara göre daha yüksek olmuştur. Salkımdaki ilk meyve, küçük meyve ve derimi yapılan meyve oranları bakımından da anacı alıç olan bitkilerden (sırasıyla %11.16, %7.91 ve %6.29) daha yüksek değerler elde edilmiştir. Yıllık sürgün uzunluğu, kalem ve anaç çapı bakımından yenidünya çöğür anacı, alıç anacına göre önemli düzeyde daha yüksek değerler vermiştir. İncelenen öteki bütün parametreler bakımından da yenidünya çöğür anacının daha kuvvetli vejetatif büyüme gösterdiği belirlenmiştir. Elde edilen bu ilk verilere göre alıç anacı, yenidünya çöğür anacına göre üzerine aşılı kalemde yaklaşık %60 bodurluk sağlamaktadır.