bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Change of Neutrophil to Lymphocyte Ratios and Infection in Patients with Acute Ischemic Stroke
Authors: Wang Lu , Guo Wen , Wang Changyi , Yang Xue , Hao Zilong , Wu Simiao , Zhang Shihong , Wu Bo , Liu Ming
Published: April 2020

Background:

Neutrophil to lymphocyte ratio (NLR) on admission was reported to be a
predictor of pneumonia after stroke. The aim of this study was to investigate the association between
the temporal change of NLR and post-stroke infection and whether infection modified the
effect of NLR on the outcome.

Methods:

We enrolled patients with acute ischemic stroke within 24 h after onset. The blood was
collected on admission, day 1, 3, 7 after admission to detect white blood cells (WBC), neutrophils,
and lymphocytes. Primary outcomes included pneumonia, urinary tract infection (UTI), other infection,
and the secondary outcome was 3-month death.

Results:

Of 798 stroke patients, 299 (37.66%) developed infection with 240 (30.23%) pneumonia,
78 (9.82%) UTI, and 9 (1.13%) other infection. The median time of infection occurrence was 48 h
(interquartile range 27-74 h) after onset. NLR reached to the peak at 36 h. For all outcomes, NLR
at 36 h after stroke had the highest predictive value than WBC, neutrophil, lymphocyte. NLR was
independently associated with the presence of any infection (odds ratio [OR] 1.11, 95% confidence
interval [CI] 1.05-1.17), pneumonia (OR 1.12, 95%CI 1.05-1.19), but not UTI (OR 0.95, 95%CI
0.89-1.01). Adding infection or the interaction term did not substantially change the OR of NLR
predicting 3-month death (OR 1.09, 95%CI 1.01, 1.17).

Conclusion:

Increased NLR around 36 h after stroke was a predictor of infection in patients with
acute ischemic stroke. The increased NLR value was associated with a higher risk of 3-month
death, which was independent of poststroke infection.
In Silico Discovery of Novel Flavonoids as Poly ADP Ribose Polymerase (PARP) Inhibitors
Authors: Shah Ashish , Parmar Ghanshyam , Seth Avinash Kumar
Published: April 2020

Background:

The concept of synthetic lethality is an emerging field in the treatment of
cancer and can be applied for new drug development of cancer as already been represented by Poly
(ADP-ribose) polymerase (PARPs) inhibitors.

Objectives:

In this study, we performed virtual screening of 329 flavonoids obtained from the Naturally
Occurring Plant-based Anti-cancer Compound-Activity-Target (NPACT) database to identify
novel PARP inhibitors.

Materials and Methods:

Virtual screening carried out using different in silico methods which include
molecular docking studies, prediction of drug-likeness and in silico toxicity studies.

Results:

Fifteen out of 329 flavonoids achieved better docking score as compared to rucaparib
which is an FDA approved PARP inhibitor. These 15 hits were again rescored using accurate
docking mode and drug-likeliness properties were evaluated. The accuracy of the docking method
was checked using re-docking. Finally NPACT00183 and NPACT00280 were identified as
potential PARP inhibitors with docking score of -139.237 and -129.36, respectively. These two
flavonoids also showed no AMES toxicity and no carcinogenicity which was predicted using
admetSAR.

Conclusion:

Our finding suggests that NPACT00183 and NPACT00280 have promising potential
to be further explored as PARP inhibitors.
Bio-Analytical Method Development and Validation for Estimation of Zaltoprofen in Human Plasma by Reverse Phase -HPLC Method
Authors: Erukulla Kishor Kumar , Renjitham Suseem Sundaram
Published: April 2020

Objective:

A particular, easy and precise reverse phase liquid chromatographic technique was developed for the
determination of Zaltoprofen in human plasma.

Methods:

The ODS C18 (250mm x 4.6mm, 5µm) column was
utilized for determination. The mobile phase contains buffer and acetonitrile (55:45 v/v). The rate of flow was 1.0
ml/min. The volume of sample infused was 10 µl. The column has been kept at a temperature of ~300C. The column
was equilibrated for no less than 30 min prior to injection of the solutions. The detection wavelength was set at of
331 nm.

Results:

The linearity experiment was performed for Zaltoprofen in the range of 0.15 to 20 µg/ml. The
observed recovery of Zaltoprofen was 98.32 %.

Conclusion:

The suggested technique has been validated and the
same is very helpful for zaltoprofen determination in human plasma.
A Label-free Electrochemical Immunosensor for Highly Sensitive Detection of TNF α, Based on Star Polymer-modified disposable ITO Electrode
Authors: Aydin Elif Burcu , Aydin Muhammet , Sezgintürk Mustafa Kemal
Published: April 2020

Background:

Biomarkers are very important disease-related biomolecules which should be
analyzed sensitive and selective in related physiological fluids or tissues. Tumor necrosis factor-α is a
type of cytokine which plays vitlly important roles in different methabolic pathways such as cell death,
survival, differentiation, proliferation and migration, and infectious and inflammatory diseases including
rheumatoid arthritis, diabetes.

Objective:

In this study, it was aimed to develop a reliable tool based on star-shaped poly(glycidyl
methacrylate) polymer coated disposable indium tin oxide electrode for determination of Tumor necrosis
factor-α, an important disease biomarker.

Methods:

Star shaped polymer was used as an interface material for anti- Tumor necrosis factor α antibodies
immobilization. The antibodies were immobilized covalently onto polymer coated indium tin
oxide electrode. Electrochemical impedance spectroscopy and cyclic voltammetry techniques were
used for all electrochemical measurements.

Results:

The suggested immunosensor exhibited a linear range between 0.02 and 4 pg/mL Tumor necrosis
factor-α, and the detection limit was found as 6 fg/mL. Scanning electron microscopy and atomic
force microscopy were used for electrode surface characterization. In addition, the suggested immunosensor
was used for Tumor necrosis factor-α sensing in human serum samples. The results displayed
recoveries between 97.07 and 100.19%. Moreover, this immunosensor had a simple fabrication
procedure and a long storage-stability.

Conclusion:

A new biosensor based on a Star shaped polymer for the ultra sensitive determination of a
biomarker Tumor necrosis factor-α was developed. The biosensor presented excellent repeatability and
reproducubility, and also wide calibration range for Tumor necrosis factor- α.
Quality Evaluation of the Tugaksheeree Samples by ATR-FTIR Spectroscopy Using Multicomponent Analysis
Authors: Patel Nikunj D. , Kanaki Niranjan S.
Published: April 2020

Background:

Numerous Ayurvedic formulations contain tugaksheeree as a key ingredient.
Tugaksheeree is the starch gained from the rhizomes of two plants, Curcuma angustifolia Roxb.
(Zingiberaceae) and Marantaarundinacea (MA) Linn. (Marantaceae).

Objective:

The primary concerns in quality assessment of Tugaksheeree occur due to adulteration or
substitution.

Method:

In the current study, Fourier Transform Infrared (FTIR) technique with Attenuated Total
Reflectance (ATR) facility was used to evaluate the tugaksheeree samples. A total of 10 different
samples were studied and transmittance mode was kept to record the spectra devoid of the pellets of
KBR. Further treatment was given with multi-component tools by considering the fingerprint region
of the spectra. Multivariate analysis was performed by various chemometric methods.

Result:

Multi-component methods, like Principal Component Analysis (PCA) and Hierarchical
Cluster Analysis (HCA), were used to discriminate the tugaksheeree samples using Minitab software.

Conclusion:

This method can be used as a tool to differentiate samples of tugaksheeree from its adulterants
and substitutes.
Social Media Use in College-age Youth: A Comprehensive Review and a Call to Action
Authors: Holmes Hilary , Lara Alba E. , Brown Gregory S.
Published: April 2020

Background:

Social media is a relatively new and impactful way to connect
millions of people around the world. The intersection of mental health and social media is
a poorly studied, yet important area of research. Specifically, with regard to college-aged
youth, social media can potentially offer an educational tool to enhance mental health
awareness or augment treatment when it is used for professional purposes by mental health
advocates or healthcare professionals. There is also the added risk of disinformation,
cyberbullying, and privacy breaches.

Objective:

This review aims to assess the current state of social media use and its influence
on mental health, especially in college-age youth.

Methods:

The authors of this paper utilized PubMed and Medline databases to review the
most recent experimental studies and literature reviews available on the topic of mental
health and social media.

Results:

Abstracts and relevant papers were read in full, and information from these studies
was cited accordingly.

Conclusion:

The authors conclude that although more research needs to be conducted, social
media may offer benefits for mental health awareness, education, and treatment, specifically
in populations such as college-age youth.
Mobile Phone Technologies in the Management of Ischemic Heart Disease, Heart Failure, and Hypertension: Systematic Review and Meta-Analysis
Authors: Indraratna Praveen , Tardo Daniel , Yu Jennifer , Delbaere Kim , Brodie Matthew , Lovell Nigel , Ooi Sze-Yuan
Published: April 2020

Background

Cardiovascular disease (CVD) remains the leading cause of death worldwide. Mobile phones have become ubiquitous in most developed societies. Smartphone apps, telemonitoring, and clinician-driven SMS allow for novel opportunities and methods in managing chronic CVD, such as ischemic heart disease, heart failure, and hypertension, and in the conduct and support of cardiac rehabilitation.

Objective

A systematic review was conducted using seven electronic databases, identifying all relevant randomized control trials (RCTs) featuring a mobile phone intervention (MPI) used in the management of chronic CVD. Outcomes assessed included mortality, hospitalizations, blood pressure (BP), and BMI.

Methods

Electronic data searches were performed using seven databases from January 2000 to June 2019. Relevant articles were reviewed and analyzed. Meta-analysis was performed using standard techniques. The odds ratio (OR) was used as a summary statistic for dichotomous variables. A random effect model was used.

Results

A total of 26 RCTs including 6713 patients were identified and are described in this review, and 12 RCTs were included in the meta-analysis. In patients with heart failure, MPIs were associated with a significantly lower rate of hospitalizations (244/792, 30.8% vs 287/803, 35.7%; n=1595; OR 0.77, 95% CI 0.62 to 0.97; P=.03; I2=0%). In patients with hypertension, patients exposed to MPIs had a significantly lower systolic BP (mean difference 4.3 mm Hg; 95% CI −7.8 to −0.78 mm Hg; n=2023; P=.02).

Conclusions

The available data suggest that MPIs may have a role as a valuable adjunct in the management of chronic CVD.
Rethinking Social Interaction: Empirical Model Development
Authors: Bjornestad Jone , Moltu Christian , Veseth Marius , Tjora Tore
Published: April 2020

Background

Social media is an integral part of human social life. More than 90% of young people use social media daily. Current theories, models, and measures are primarily based on face-to-face conceptions, leaving research out of sync with current social trends. This may lead to imprecise diagnoses and predictions.

Objective

To develop a theoretically based empirical model of current social interfaces to inform relevant measures.

Methods

A three-stage, qualitative, data-collection approach included anonymous individual Post-it notes, three full-class discussions, and 10 focus groups to explore 82 adolescents’ relational practices. Data analysis followed a meaning-condensation procedure and a field-correspondence technique.

Results

We developed an empirical model that categorizes adolescents’ social interactions into five experiential positions. Four positions result from trajectories relating to social media and face-to-face social interaction. Positions are described by match or mismatch dynamics between preferred and actual social platforms used. In matched positions, individuals prefer and use both face-to-face and social media platforms (position 1), prefer and use face-to-face platforms (position 2), or prefer and use social media platforms (position 3). In mismatched positions, individuals prefer face-to-face interactions but use social media platforms (position 4) or prefer social media but use face-to-face platforms (position 5). We propose that matched positions indicate good social functioning while mismatched positions indicate serious social challenges.

Conclusions

We propose a model that will expand previous unidimensional social interaction constructs, and we hypothesize that the described match and mismatch analyses provide conceptual clarity for research and practical application. We discuss prediction value, implications, and model validation procedures.
Patient-Reported Outcomes During Immunotherapy for Metastatic Melanoma: Mixed Methods Study of Patients’ and Clinicians’ Experiences (Preprint)
Authors: Tolstrup Lærke K , Pappot Helle , Bastholt Lars , Zwisler Ann-Dorthe , Dieperink Karin B
Published: April 2020

BACKGROUND

The benefits of electronic patient reported outcomes (PRO) questionnaires have been demonstrated in many settings, including in hospitals and patient homes. However, it remains to be investigated how melanoma patients and their treating clinicians experience the electronic self-reporting of side effects and the derived communication.

OBJECTIVE

The primary objective of this study was to examine patients’ and clinicians’ experiences with an eHealth intervention for weekly monitoring of side effects during treatment with immunotherapy.

METHODS

An eHealth intervention based on questions from the PRO-Common Terminology Criteria for Adverse Events (CTCAE) library was used and tested in a randomized clinical trial with patients receiving immunotherapy for malignant melanoma and clinicians at a university hospital in Denmark. On a weekly basis, patients reported their symptoms from home during the treatment via a provided tablet. The electronic patient reports were available to clinicians in the outpatient clinic. A mixed methods approach was applied to investigate the patients’ and clinicians’ experiences with the intervention. Data from patient experiences were collected in a short survey, the Patient Feedback Form. Moreover, a subset of the patients participating in the survey was interviewed about their experience. Furthermore, one focus group interview with clinicians was carried out to elucidate their views.

RESULTS

A total of 57 patients completed the Patient Feedback Form, and 14 patients were interviewed. The focus group interview included 5 clinicians. Overall, patients and clinicians were satisfied with the tool. They believed it enhanced patients’ awareness of side effects and increased their feeling of involvement. The patients reported that it was easy to fill out the questionnaire and that it made sense to do so. However, a minority of the patients expressed in the interviews that they did not believe that the health care professionals had seen their reports when they came to the clinic, and that the reporting did not lead to increased contact with the department.

CONCLUSIONS

Overall, satisfaction with the eHealth intervention was high among patients and their treating clinicians. The tool was easy to use and contributed to greater symptom awareness and patient involvement. Thus, in terms of patient and clinician satisfaction with the tool, it makes sense to continue using the tool beyond the project period.

CLINICALTRIAL

ClinicalTrials.gov NCT03073031; https://tinyurl.com/tjx3gtu
Efficacy of an Online Physical Activity Intervention Coordinated With Routine Clinical Care: Protocol for a Pilot Randomized Controlled Trial (Preprint)
Authors: Rockette-Wagner Bonny , Fischer Gary S , Kriska Andrea M , Conroy Molly B , Dunstan David , Roumpz Caroline , McTigue Kathleen M
Published: April 2020

BACKGROUND

Most adults are not achieving recommended levels of physical activity (150 minutes/week, moderate-to-vigorous intensity). Inadequate activity levels are associated with numerous poor health outcomes, and clinical recommendations endorse physical activity in the front-line treatment of obesity, diabetes, dyslipidemia, and hypertension. A framework for physical activity prescription and referral has been developed, but has not been widely implemented. This may be due, in part, to the lack of feasible and effective physical activity intervention programs designed to coordinate with clinical care delivery.

OBJECTIVE

This manuscript describes the protocol for a pilot randomized controlled trial (RCT) that tests the efficacy of a 13-week online intervention for increasing physical activity in adult primary care patients (aged 21-70 years) reporting inadequate activity levels. The feasibility of implementing specific components of a physical activity clinical referral program, including screening for low activity levels and reporting patient program success to referring physicians, will also be examined. Analyses will include participant perspectives on maintaining physical activity.

METHODS

This pilot study includes a 3-month wait-listed control RCT (1:1 ratio within age strata 21-54 and 55-70 years). After the RCT primary end point at 3 months, wait-listed participants are offered the full intervention and all participants are followed to 6 months after starting the intervention program. Primary RCT outcomes include differences across randomized groups in average step count, moderate-to-vigorous physical activity, and sedentary behavior (minutes/day) derived from accelerometers. Maintenance of physical activity changes will be examined for all participants at 6 months after the intervention start.

RESULTS

Recruitment took place between October 2018 and May 2019 (79 participants were randomized). Data collection was completed in February 2020. Primary data analyses are ongoing.

CONCLUSIONS

The results of this study will inform the development of a clinical referral program for physical activity improvement that combines an online intervention with clinical screening for low activity levels, support for postintervention behavior maintenance, and feedback to the referring physician.

CLINICALTRIAL

ClinicalTrials.gov NCT03695016; https://clinicaltrials.gov/ct2/show/NCT03695016.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/18891
Opportunities for Mobile App–Based Adherence Support for Children With Tuberculosis in South Africa (Preprint)
Authors: Morse Rachel M , Myburgh Hanlie , Reubi David , Archey Ava E , Busakwe Leletu , Garcia-Prats Anthony J , Hesseling Anneke C , Jacobs Stephanie , Mbaba Sharon , Meyerson Kyla , Seddon James A , van der Zalm Marieke M , Wademan Dillon T , Hoddinott Graeme
Published: April 2020

UNSTRUCTURED

Tuberculosis is the number one infectious cause of death globally. Young children, generally those younger than 5 years, are at the highest risk of progressing from tuberculosis infection to tuberculosis disease and of developing the most severe forms of tuberculosis. Most current tuberculosis drug formulations have poor acceptability among children and require consistent adherence for prolonged periods of time. These challenges complicate children’s adherence to treatment and caregivers’ daily administration of the drugs. Rapid developments in mobile technologies and apps present opportunities for using widely available technology to support national tuberculosis programs and patient treatment adherence. Pilot studies have demonstrated that mobile apps are a feasible and acceptable means of enhancing children’s treatment adherence for other chronic conditions. Despite this, no mobile apps that aim to promote adherence to tuberculosis treatment have been developed for children. In this paper, we draw on our experiences carrying out research in clinical pediatric tuberculosis studies in South Africa. We present hypothetical scenarios of children’s adherence to tuberculosis medication to suggest priorities for behavioral and educational strategies that a mobile app could incorporate to address some of the adherence support gaps faced by children diagnosed with tuberculosis. We argue that a mobile app has the potential to lessen some of the negative experiences that children associate with taking tuberculosis treatment and to facilitate a more positive treatment adherence experience for children and their caregivers.
Social media as a recruitment platform for a nationwide online survey of COVID-19 knowledge, beliefs, and practices in the United States: Methodology and feasibility analysis (Preprint)
Authors: Ali Shahmir H. , Foreman Joshua , Capasso Ariadna , Jones Abbey M. , Tozan Yesim , DiClemente Ralph J.
Published: April 2020

BACKGROUND

The COVID-19 pandemic has evolved into one of the most impactful health crises in modern history. The rapid onset and evolution of the pandemic has compelled researchers to explore innovative ways to efficiently collect public health data in a timely manner. Social media platforms, such as Facebook, have been explored as a recruitment tool for research in other settings; however, their feasibility for collecting data on population beliefs and practices during infectious disease epidemics, such as COVID-19, and their capacity to yield nationally representative samples in these contexts remain unexplored.

OBJECTIVE

This study has two aims 1) describe the methodology used to recruit a nationwide sample of adults residing in the United States to participate in a survey on COVID-19 knowledge, beliefs, and practices, and 2) outline the preliminary findings related to recruitment, challenges using social media as a recruitment platform, and strategies used to address these challenges.

METHODS

A Facebook advertisement campaign was used to disseminate the link to an online Qualtrics survey between March 20-30, 2020. Two supplementary male-only and racial minority- targeted advertisements with otherwise identical characteristics to the original advertisement were created on the sixth and tenth day of recruitment, respectively, to address issues of disproportionate female- and White-oriented gender- and ethnic-skewing observed in the advertisement’s reach and response trends.

RESULTS

The advertisements cumulatively reached 236,017 individuals and resulted in 9,609 clicks (4.07% reach). In total, 6,602 participant responses were recorded (68.7% of those who clicked on the advertisement). Total cost of the advertisement was $906, resulting in costs of $0.09 per click, $0.14 per response (all surveys), and $0.18 per full response (completed surveys). Implementation of the supplementary male-only advertisement successfully improved the cumulative percentage of male respondents from approximately 20% to 40%.

CONCLUSIONS

The social media advertisement campaign was an effective and efficient strategy to collect large scale, nationwide data on COVID-19 within a short time period. However, significant limitations included gender and racial skewing, which may have resulted from Facebook’s cost optimization algorithms, and advertisement review challenges. Future research should attempt to address such challenges. These findings can inform future research on the use of social media recruitment for the rapid collection of survey data on knowledge, beliefs and practices related to significant public health problems, including rapidly evolving pandemics such as COVID-19.
Topic Modeling of Social Networking Service Data on Occupational Accidents in Korea: Latent Dirichlet Allocation Analysis (Preprint)
Authors: Min Kyoung-Bok , Song Sung-Hee , Min Jin-Young
Published: April 2020

BACKGROUND

In most industrialized societies, regulations, inspections, insurance, and legal options are established to support workers who suffer injury, disease, or death in relation to their work; in practice, these resources are imperfect or even unavailable due to workplace or employer obstruction. Thus, limitations exist to identify unmet needs in occupational safety and health information.

OBJECTIVE

The aim of this study was to explore hidden issues related to occupational accidents by examining social network services (SNS) data using topic modeling.

METHODS

Based on the results of a Google search for the phrases occupational accident, industrial accident and occupational diseases, a total of 145 websites were selected. From among these websites, we collected 15,244 documents on queries related to occupational accidents between 2002 and 2018. To transform unstructured text into structure data, natural language processing of the Korean language was conducted. We performed the latent Dirichlet allocation (LDA) as a topic model using a Python library. A time-series linear regression analysis was also conducted to identify yearly trends for the given documents.

RESULTS

The results of the LDA model showed 14 topics with 3 themes: workers’ compensation benefits (Theme 1), illicit agreements with the employer (Theme 2), and fatal and non-fatal injuries and vulnerable workers (Theme 3). Theme 1 represented the largest cluster (52.2%) of the collected documents and included keywords related to workers’ compensation (ie, company, occupational injury, insurance, accident, approval, and compensation) and keywords describing specific compensation benefits such as medical expense benefits, temporary incapacity benefits, and disability benefits. In the yearly trend, Theme 1 gradually decreased; however, other themes showed an overall increasing pattern. Certain queries (ie, musculoskeletal system, critical care, and foreign workers) showed no significant variation in the number of queries.

CONCLUSIONS

We conducted LDA analysis of SNS data of occupational accident–related queries and discovered that the primary concerns of workers posting about occupational injuries and diseases were workers’ compensation benefits, fatal and non-fatal injuries, vulnerable workers, and illicit agreements with employers. While traditional systems focus mainly on quantitative monitoring of occupational accidents, qualitative aspects formulated by topic modeling from unstructured SNS queries may be valuable to address inequalities and improve occupational health and safety.
Case Report: Embodied Virtual Reality Mirror Visual Feedback for an Adult with Cerebral Palsy (Preprint)
Authors: Bullock Kim , Muccini Julie , Bronte Stewart Helen , Bailenson Jeremy , Paul Margot , Stevenson Won Andrea , Birckhead Brandon , Miner Adam
Published: April 2020

BACKGROUND

Virtual reality-assisted physical therapy is a promising treatment for children with cerebral palsy. However, thus far, it has not been used for adult patients.

OBJECTIVE

The following case report examines the safety and feasibility of customized virtual reality interventions for an adult patient with cerebral palsy who was experiencing right sided pain, weakness, dystonias.

METHODS

This research included two phases of intervention, which were based on the principles of mirror visual feedback, occasionally termed “mirror box therapy.” The patient used self-report rating scales to monitor anxiety and depression levels, as well as provided verbal feedback regarding pain levels.

RESULTS

The treatments were well tolerated, and the patient reported improved function in the injured limb. However, the duration of pain relief was only 2–4 days between sessions, causing the patient to require ongoing in office virtual reality treatments.

CONCLUSIONS

The implications of these findings for the future treatment of such patients are discussed.
ROBUST RECURSIVE IDENTIFICATION OF HAMMERSTEIN MODELS BASED ON WEISZFALD ALGORITHM
Authors: Filipović Vojislav
Published: April 2020

The Hammerstein models can accurately describe a wide variety of nonlinear systems (chemical process, power electronics, electrical drives, sticky control valves). Algorithms of identification depend, among other, on the assumption about the nature of stochastic disturbance. Practical research shows that disturbances, owing the presence of outliers, have a non-Gaussian distribution. In such case it is a common practice to use the robust statistics. In the paper, by analysis of the least favourable probability density, it is shown that the robust (Huber`s) estimation criterion can be presented as a sum of non-overlapping - norm and - norm criteria. By using a Weiszfald algorithm - norm criterion is converted to - norm criterion. So, the weighted - norm criterion is obtained for the identification. The main contributions of the paper are: (i) Presentation of the Huber`s criterion as a sum of - norm and - norm criteria; (ii) Using the Weiszfald algorithm  – norm criterion is converted to a weighted - norm criterion; (iii) Weighted extended least squares in which robustness is included through weighting coefficients are derived for NARMAX (nonlinear autoregressive moving average with exogenous variable) . The illustration of the behaviour of the proposed algorithm is presented through simulations.
Cuerpos desplazados y ciudades heridas: procesos de des(re)territorialización de personas menores de edad en situación de calle y de riesgo social
Authors: Garcez Leme Maria Cecilia , Blanck de Oliveira Lilian
Published: April 2020

El artículo presenta la síntesis de un estudio bibliográfico sobre desarrollo urbano y procesos de des(re)territorialización de personas menores de edad en situación de calle y de riesgo social, el cual tiene como objetivo analizar posibles relaciones entre estos dos factores. Metodológicamente, el estudio asume el enfoque cualitativo, de carácter bibliográfico, y articula tres temáticas específicas: desarrollo urbano, territorio e infancia vulnerabilizada, como aporte para una investigación doctoral, la cual, a través de un análisis crítico de la realidad urbana, indagará las causas de la presencia y/o permanencia de niños, niñas y adolescentes en la calle, y la relación de este fenómeno con los modelos de desarrollo.
El concurso desde una perspectiva procesal
Authors: Carrasco Delgado Nicolás Ignacio Ariel
Published: April 2020

Bankruptcy Law possesses a certain functionality, organization and structure which is not easily reconcilable with a contractualist or privatist view. The need for the coordination on the part of creditors (a central aspect of its correct functioning) demands that procedural instruments foresake the individual consideration of the interests of creditors’ sole interests, and in doing so reinforces the need for them to act as a group (the collective action problem). In accordance with this logic, the complete adaptation of procedural law in order to understand its purposes is hereby explained. In this context, bankruptcy procedural law avails of a series of instruments which seek to achieve the efficiency goals of the bankruptcy proceedings.
STUDI HUMAS DI MADRASAH ALIYAH MUHAMMADIYAH 1 MALANG
Authors: . Sunarto
Published: April 2020

Sunarto *)Fakultas Agama Islam UMMABSTRACTThis research is meant to know and elaborating clearly the society relationdevelopment at Madrasah Aliyah Muhammadiyah I Malang which cover: developmentplan of madrasah relation with society, execution of activity of liaison covering;activity type and form, executor, and penanggungjawab of activity, and evaluate resultof the society relation development; evaluation technique, period of evaluation, andexploiting of evaluation result. The research result can be concluded that MadrasahAliayah Muhammadiyah I of Malang have owned activity plan in yielded PublicRelations area. As for fundamental component which decanted in plan is target, activityform and type, time execution of activity, penanggngjawab of activity, executor ofactivity, evaluation, and activity budget. All of activity in the field of public relations inMadrasah Aliyah Muhammadiyah I of Malang executed under the chief of madrasahresponsibility that delegated to Chief Of Public Relations. And all of activity plan havebeen executed by various activity form and type except free medication and masscircumcision. The result evaluation of public relations development of Madrasah AliyahMuhammadiyah I of Malang executed at two aspect, that are process aspect and resultaspect. The evaluation process executed in the middle of and final of every activity,while evaluation result of executed at the (time) of activity have. At process aspect,evaluation executed to be able to know the parts of un-executed better and anticipateearly possibility of[is existence of resistance at execution of activity which still will takeplace. While evaluation result of executed by chief of Madrasah and by sejawat throughforum co-ordinate and more have the character of to dig information.
MENGEJAWANTAHKAN NILAI TASAWUF DALAM DIRI GURU
Authors: W. Truli Maulida
Published: April 2020

The position of educators in the world of education has received important attention from the government. They are an important medium in the transformation of knowledge for students in particular and for the progress of the nation in general. That is, they are the bearers of socio-cultural tasks whose function is to prepare the younger generation according to the ideals of the nation. Therefore, leading people in the right direction is the formal duty of a teacher. So, every educator should have a manifestation of Sufism values in teaching students. This research paper wants to examine how to realize the values of Sufism in educators to students. Then, the goal to be achieved in this discussion is to describe the manifestation of Sufism values in the teacher / educator as a noble task. This discussion uses a descriptive method because it is limited to providing a description of a phenomenon based on library research.
REORIENTASI PENDIDIKAN ISLAM DI ERA REVOLUSI INDUSTRI 4.0
Authors: M M Samkhan
Published: April 2020

The implementation of Islamic education is still oriented towards the romanticism of the past rather than looking at the future. The main challenges in the industrial era 4.0 include the issue of the quality of teaching resources. Therefore this study wants to answer; the orientation of the educational paradigm as an epistemological framework which underlies the set of ideas or concepts in the implementation of education as well as the actualization and evaluation of education. The effort to transform Islamic education uses an integrated approach between the reasoning of Bayani, Burhani, and Irfani. The hope, the integrated paradigm produces a scientific structure that emphasizes the creation of know-why and know-how competencies, rather than know-what. In this case it is a philosophical form of Islamic education in its axiological and epistemological aspects, so that professional Islamic education can give birth to a generation of knowledgeable knowledge, mastering technology in addition to holding fast to the religion of God.
Política Pública e Reforma Agrária: Uma Análise dos Principais Indicadores da Política de Assentamentos Rurais
Authors: Figueredo Cléria , Silva Christian Luiz da
Published: April 2020

RESUMO: O presente artigo, apresenta resultados dos principais indicadores da Politica de Reforma Agrária, desde a sua implementação na década de 1970 até 2017. A metodologia adotada foi o estudo de caso, com o levantamento dos dados dos Imóveis rurais obtidos para fins de criação de Projetos de Assentamento, Famílias Assentadas e de Supervisão Ocupacional destes projetos. Os resultados mostram que a cada mudança de governo, a agenda politica para criação e assentamento de famílias sofre altos e baixos, bem como apontam para a necessidade de novas pesquisas que deem conta de avaliar se os objetivos da Politica de Reforma Agraria atingiram àqueles estabelecidos na legislação que regulamenta e legitima esta politica desde sua implementação.
National innovation system of India: genesis and key performance indicators
Authors: Bokachev Ivan N.
Published: April 2020

The article discusses the formation of the India’s national innovation system (NIS), which passes through the phases of protectionism, liberalism and duality. Special attention is paid to the peculiarities of the India’s innovation system based on efficiency indicators, such as gross domestic expenditures on research and development, exports of high-tech products, as well as foreign direct investment in high technology sector. The paper notes that India is one of the most attractive countries for investing in the innovation sector. The author also highlights the negative aspects of NIS development in India, such as imbalances in income and wages, low literacy and high levels of poverty, uneven inflow of foreign investment in different regions, lack of innovation culture in manufactured products, etc. The article especially notes that India after the start of the process of economic liberalization has grown economically in terms of GDP, exports, employment, investment, the inflow of foreign technology and investment, the ICT industry, and the internationalization of investment in research and development sphere.
Physical-ceramic characterization of clays used in the manufacture of mansory products for construction
Authors: García León Ricardo Andrés , Flórez Solano Eder Norberto , Acevedo Peñaloza Carlos Humberto
Published: April 2020

Nowadays, in Colombia, specifically in the north-eastern, in Santander region, the process of mixing the ceramic paste used to manufacture masonry products for construction (H- 10 bricks, tiles, roof tiles, etc.) is done manually. For this reason, approximately 70% of the companies do not possess the technological tools which facilitate the prediction of the behavior of the raw material (clay). The main objective of this research is to formulate mixtures at a laboratory-level in order to verify the physical properties of ceramic raw materials used by a company which was takenas a sample. The research development was carried out through the execution of tests and laboratory analysis, taking into account the formulation of mixtures with the help of Statgraphics Centurion XV software in order to obtain combinations of raw materials according to the requirements of the current standard techniques. The results demonstrate the importance of using statistical programs for the improvement of systems and processes, predicting the behavior of raw materials as well as conducting pilot tests, taking into account the laboratory analyses in the ceramic industry. Conclusions: The results show that the mixture combinations obtained have the necessary parameters to meet the current standards such as resistance and absorption, which will optimize the economic and physical resources of the company, as well as the quality of the final product.
Asociatividad para la administración los sistemas de producción campesina
Authors: Fonseca-Carreño Nelson Enrique , González Moreno Manuel Ricardo , Narváez Benavides Carlos Arturo
Published: April 2020

Introducción: Los sistemas de producción campesina – SPC- son un componente fundamental para el desarrollo de economías locales a través de la generación de empleo, inclusión de género, seguridad y soberanía alimentaria. La investigación evalúa el beneficio percibido de los productores agropecuarios a través de la asociatividad en los SPC en la Provincia del Sumapaz, bajo elementos estratégicos de competitividad, mediante indicadores económicos, sociales y productivos. Metodología: Los SPC fueron seleccionados de 80 fincas distribuidas en los municipios que conforman la provincia. Adicionalmente, se consideraron características como: tenencia de tierra, fuentes de ingreso, participación en grupos asociativos y fuentes de financiación. Por lo cual, el grado de importancia para evaluar la asociatividad se deriva de sumar los indicadores: Productividad, Equidad, Estabilidad, Confiabilidad, Adaptabilidad, y Autogestión. Resultados: 20 SPC, evidenciando el uso de prácticas productivas para generar un aumento de la cantidad, calidad y frecuencia de los productos e incremento de ingresos, que utilizan para adecuación de infraestructura, compra de tecnología, materia prima e insumos. Asimismo, se determinó el grado de asociatividad de 5 SPC priorizados, dentro de los cuales 3 SPC arrojaron índices superiores del 70%, suscitando beneficios a la comunidad, lo que demuestra que la producción no es dependiente del uso de insumos externos, existe un aumento en la productividad por unidad de superficie, mediante la adopción y difusión de tecnologías. En conclusión, existe un gran avance respecto a la aceptación de la asociatividad entre los SPC, su inclusión e integración demuestran alternativas productivas y comerciales que son favorables para responder a los retos y oportunidades del mercado regional.
Hollandalı Göçmen Yazar Murat Işık'tan Bir Göç ve Kültürlenme Romanı: Verloren G
Authors: Gündüz Nazli
Published: April 2020

Eski çağlardan günümüze açlık, kuraklık, husumet ya da daha iyi eğitim arayışı insanın yaşadığı toprakları bırakıp aynı topraklarda başka yerlere veya başka memleketlere gitmesine neden olmaktadır. Bu makalede, küçük yaşta göçe tanıklık etmiş olan Zaza/Alevi asıllı Hollandalı yazar Murat Işık kaleme aldığı ve ailesinin gerçek yaşam öyküsünden izler taşıyan Verloren Grond (Kayıp Toprak) romanında iç göç etmenlerini ne şekilde ele aldığı incelenmiştir. Eserde kırdan kıra ve oradan da büyük şehre göç eden Uslu ailesinin önce zorunlu, sonra gönüllü göç edişi, aile bireylerinin duygu, düşünce, umut ve hayal kırıklıkları eşliğinde gündeme getirilir. Eser, göç kuramı itme-çekme modeli ve göç üzerine oluşturulan birtakım itici ve çekici etmenler aracılığı ile irdelenir. Bireyler yaşadıkları yerlerden belirli itici nedenlerden dolayı ayrılarak kendilerini çekici etmenlerin beklediğini düşündükleri yerlere giderler. Eserde en önemli itici etmen aile reisinin bacağının kesilmesi ve buna karşılık ailenin ekonomik kurtuluşu için çekici etmen teşkil eden kendi köyünde bulunan babadan kalma tarladır. Toprak olgusu insanoğlu için önemlidir çünkü ata mirasıdır, aidiyeti, kimliği ve özgürlüğü ifade eder. İkinci önemli itici etmen deprem ise çekici etmen olarak büyük şehre gitme fikrini doğurur. Göçlerin ardından farklı sosyal, kültürel ve psikolojik uyum sorunları yaşayan aile bireyleri kültürlenme süreci ile karşı karşıya kalır.
Corporate Social Responsibility and the Market Reaction to Negative Events: Evidence from Inadvertent and Fraudulent Restatement Announcements
Authors: Bartov Eli , Marra Antonio , Momenté Francesco
Published: April 2020

We advance a theory asserting that CSR performance may exacerbate, not necessarily moderate, a company's negative stock price response to negative events. In testing this theory, we hypothesize and find that CSR performance alleviates (magnifies) the immediate negative stock price response to inadvertent (fraudulent) restatement announcements, and that these findings are robust to specifications that consider alternative CSR measures and a multitude of control variables shown by prior research to have explanatory power for the cross-sectional variation in stock returns. Overall, using restatement announcements as a channel through which CSR performance may affect company value, we show, in contrast to prior research, that depending on management conduct leading to the restatement, a company's CSR performance may destroy, not necessarily enhance, firm value. Our findings may, thus, inform researchers, market participants, and regulators.

Data Availability: The data used in this study are publicly available from sources indicated in the text.
Analisis Kepuasan Pelanggan dengan Metode Servqual dan Pendekatan Structural Equation Modelling (SEM) pada Perusahaan Jasa Pengiriman Barang di Wilayah Kota Pekanbaru
Authors: Lubis Fitriani Surayya , Rahima Annisa Putri , Umam Muhammad Isnaini Hadiyul , Rizki Muhammad
Published: April 2020

Kualitas pelayanan pada umumnya akan selalu mendapat perhatian besar dari perusahaan penyedia layanan/ jasa sebab mempunyai hubungan langsung dengan kemampuan bersaing dan tingkat keuntungan perusahaan. Pada penelitian ini akan dibahas kualiatas pelayanan jasa pada perusahaan ekspedisi wilayah Kota Pekanbaru yang bergerak di bidang pengiriman barang/ paket dengan tujuan  wilayah Pekanbaru, Provinsi Riau, dan Kota-Kota Besar di Indonesia. Penelitian ini masih berupa usulan penggunaan metode/ pendekatan pengukuran kualitas pelayanan dengan tujuan yang diharapkan adalah untuk mendapatkan kriteria faktor prioritas utama kualitas pelayanan serta kesesuaian antara harapan konsumen terhadap kualitas layanan yang ada. Faktor-faktor kualitas pelayanan dalam hal ini terdiri dari Tangible, Reliability, Responsiveness, Assurance, dan Empathy. Metode Service Quality (SERVQUAL) dan Structural Equation Modelling (SEM) diusulkan untuk menganalisis faktor-faktor tersebut. Metode SERVQUAL akan membangun model kualitas jasa melalui pengukuran perbedaan antara harapan konsumen mengenai kinerja (pelayanan) dari perusahaan dan penilaian konsumen mengenai kinerja aktual pada kelima faktor kualitas pelayanan. Sementara itu, analisis dengan metode SEM  menggunakan model pengukuran Confirmatory Factor Analysis (CFA) dan Multiple Regression Analysis dilakukan untuk mengetahui apakah ada hubungan yang signifikan antara faktor kriteria kepuasan pelanggan terhadap kinerja (pelayanan) perusahaan.
Catálogo de líquenes de Asturias
Authors: De la Torre Fernández Fernando , Fernández Ordóñez Mª Carmen
Published: April 2020

Catálogo de líquenes de Asturias. Catálogo de los líquenes de Asturias en el que se recogen 340 táxones en 180 localidades, provenientes de 2133 citas. Se incluyen datos procedentes tanto de referencias bibliográficas como de la revisión del Herbario FCO Lich.
Aspectos metodológicos del naturalismo matemático. La aproximación conjuntista de Maddy
Authors: Caba Antonio
Published: April 2020

ResumenEntre otras razones, el reciente rechazo por parte de Maddy de la tesis de indispensabilidad significa que ya no considera el realismo como opción viable, tal como pensaba en los primeros novente. Con objeto de proporcionar una teoría filosófica que cuadre con la práctica, propone una posición naturalista en la que la metodología de las matemáticas no necesite justificación externa a la propia matemática. Pese a todo, el campo elegido por Maddy para desarrollar su planteamiento, es decir, la justificación de los axiomas de la teoría de conjuntos, no ha cambiado. Este artículo trata de hacer un esquema crítico de los principales aspectos de este cambio.Palabras claveFundamentación conjuntista-Maddy-naturalismo matemático
Loyalty of Green Tourist : Mediating Role of Satisfaction
Authors: Yuniati Nining , Priyanto Sony Heru , Suharti Lieli , Kusuma Linda
Published: April 2020

The paper aims to test a research model of the mediating role of satisfaction in creating loyalty of green tourists. The importance of loyalty refers to a number of unique characteristics of green tourists such as being associated with the middle class, high spenders, staying longer than common tourists, high involvement, and tolerance. By using SEM a mediation test was carried out related to the position of customer satisfaction (GCS) in mediating its decision to buy in an environmentally friendly hotel (GP) and its loyalty (GCL). In short, to get loyal customers, services must be created in order to encourage customer satisfaction.

Keywords: green hotel, green tourist, loyalty, purchasing, satisfaction