bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Prognostic Markers in Determining the Mortality in Patients Diagnosed With Pneumonia in Intensive Care
Authors: Altaş Ömer Faruk , Kızılkaya Mehmet
Published: June 2021

Objective: In this study, we aimed to reveal the level of predicting mortality of the Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratios (TLR) calculated in patients hospitalized with the diagnosis of pneumonia in the intensive care unit when compared with other prognostic scores. Method: The hospital records of 112 patients who were admitted to the intensive care unit between January 2015 and January 2018 and met the inclusion criteria were retrospectively reviewed. The patients’ demographic data, the NLR and PLR levels, and the APACHE II (Acute Physiology and Chronic Health Evaluation II) and SOFA (Sequential Organ Failure Assessment) scores were calculated from the patient files. Results: Of the 112 patients examined, 70 were males. The risk analysis showed that the male gender had 2.7 times higher risk of mortality. The NLR, PLR, APACHE II, and SOFA values were found statistically significant in predicting mortality (p<0.001). An evaluation of the risk ratios demonstrated that each one point increase in the NLR increased the mortality risk by 5%, and each one point increase in the SOFA score increased the mortality risk by 13% (p<0.05). In the ROC (receiver operating characteristic) analysis, the NLR assessment proved to be the most powerful, most specific, and sensitive test. The cut-off values were 11.3 for the NLR, 227 for the PLR, 29.8 for the APACHE II scores, and 5.5 for the SOFA scores. Conclusion: We believe that NLR and PLR are strong and independent predictors of mortality that can be easily and cost-effectively tested.
THE IMPACT OF BREXIT ON BRITISH-EUROPEAN RELATIONS
Authors:   Moldova State University, Cebotari Svetlana , Budurina-Goreacii Carolina ,   Moldova State University
Published: June 2021

The exit of Great Britain from the European Union, “Brexit”, respectively “British exit”, has become one of the most important processes that trouble and concern the European world and not only. The impact of Brexit on British-European relations is considerable. Withdrawal of the United Kingdom of Great Britain and Northern Ireland from the European Community. were argued by a series of arguments that can be grouped according to three major considerations: economic, political and security. Analyzing Brexit, it can be seen that the separation of the United Kingdom from the European Union is a phenomenon that can only bring disadvantages to both parties, as well as European security. Regarding the security of the two entities, Brexit is considered as a risk, but also an opportunity for Great Britain, as well as for the states of the European Union. This article aims to highlight the main consequences of Brexit on British-European relations, including the British Overseas Territories.
A Study to Assess the Knowledge, attitude and practice of Nursing officers Regarding Covid-19 at selected Covid Care Centre, Chamarajanagar
Authors: D G Vishakantamurthy , Hemeshamurthy Hemeshamurthy , R Jayashree
Published: June 2021

As COVID-19 pandemic has caused unprecedented challenges to health care professionals. Knowledge, attitude, practice of health care workers of India towards the transmission and prevention plays vital role for effective control measures. The study was conducted to assess the knowledge, attitude and practice of the Nursing officers regarding Covid-19 at selected Covid Care Centre Chamarajanagar. In this study, a web-based cross-sectional survey was conducted between August 2020 to September 2020. A 37-item questionnaire was generated, Cronbach’s alpha was used to measure the internal consistency of the questionnaire & randomly distributed among nursing officers the using Google forms through social media networks. The chi-square test or Fischer exact test was used to compare categorical data and multiple linear regression was used to identify factor influencing KAP. Among 50 participants, the overall knowledge, attitude and practice score was 85.5%, 83.66% and 79.8% consecutively. Majority of nursing officers demonstrated preceded good knowledge, positive attitude and good practice regarding COVID-19 pandemic.
A Study to assess the knowledge regarding prevention of Cardiovascular Diseases (CVD) among Obese women in selected urban community areas at Mangalore
Authors: Varghese Neethu , Shine John
Published: June 2021

Background: Cardiovascular disease (CVD) is the leading cause of death in women and primary target for prevention. Obesity is an important biological risk factor for cardiovascular disease (CVD). The main aim of this study was to answer the question regarding knowledge about preventive measures of CVD. A further aim was to replicate previous findings that obese individuals are at higher risk of developing other biological risk factors for CVD. Objectives of the study: To identify the knowledge level of obese women regarding prevention of cardiovascular disease in a selected community at Mangalore. Method: A descriptive study was conducted among 50 obese women who were selected by Purposive sampling technique. The study was conducted in local areas, at Mangalore. Data was collected through baseline information, structured knowledge questionnaire. The data collected was analysed and interpreted based on descriptive and inferential statistics. Result: Majority of the samples belonged in the age group of 40-45 years (40%), most of their BMI were in obese category (64%), nearly half of the subjects completed pre university education (40%), 64% of the subjects were office workers and have not attained menopause, almost half of them had 2 pregnancies (48%) and majority of them did not undergo hormone replacement therapy (80%), family history of CVD and obesity were 72% and 56% respectively, majority of people had personal history of diabetes mellitus (36%). With regard to level of knowledge, among 50 obese women 50% had average knowledge, 34% had good knowledge, 6% had very good knowledge and 10% had poor knowledge about prevention of cardiovascular diseases. There was a significant association for age, type of occupation, number of pregnancies, hormone replacement therapy and personal history of CVD with knowledge of obese women and no association found for BMI, menopause, family history of CVD and obesity. Conclusion: Knowledge level of obese women regarding prevention of cardiovascular diseases is comparatively low. Various multisectoral approaches are required to improve their knowledge which would help to improve their quality of life.
Resource-efficient pooled sequencing expands translational impact in solid tumors
Authors:   Memorial Sloan Kettering Cancer Center, New York, USA, DiNatale Renzo , Mano Roy , Makarov Vladimir , Rusk Nicole , Drill Esther , Winer Andrew , Sankin Alexander , Yoo Angela , Freeman Benjamin , Hsieh James , Chen Ying-Bei , Coleman Jonathan , Berger Michael , Ostrovnaya Irina , Chan Timothy , Russo Paul , Reznik Ed , Hakimi Ari
Published: June 2021

Intratumoral genetic heterogeneity (ITH) poses a significant challenge to utilizing sequencing for decision making in the management of cancer. Although sequencing of multiple tumor regions can address the pitfalls of ITH, it does so at a significant increase in cost and resource utilization. We propose a pooled multiregional sequencing strategy, whereby DNA aliquots from multiple tumor regions are mixed prior to sequencing, as a cost-effective strategy to boost translational value by addressing ITH while preserving valuable residual tissue for secondary analysis. Focusing on kidney cancer, we demonstrate that DNA pooling from as few as two regions significantly increases mutation detection while reducing clonality misattribution. This leads to an increased fraction of patients identified with therapeutically actionable mutations, improved patient risk stratification, and improved inference of evolutionary trajectories with an accuracy comparable to bona fide multiregional sequencing. The same approach applied to non-small-cell lung cancer data substantially improves tumor mutational burden (TMB) detection. Our findings demonstrate that pooled DNA sequencing strategies are a cost-effective alternative to address intrinsic genetic heterogeneity in clinical settings.
PREVALÊNCIA DA HIPOMINERALIZAÇÃO MOLAR INCISIVO (HMI) EM CRIANÇAS ATENDIDAS EM CLÍNICA DE FACULDADE
Authors: Serrão Karen Marques , Rédua Renato Barcellos , Valentim Flavia Bridi , Campos Fernanda de Souza , Brum Bianca Mischiatti , Pinas Jasmine Lorentz
Published: June 2021

A Hipomineralização Molar Incisivo (HMI) é descrita como as opacidades demarcadas que acometem até os quatro primeiros molares permanentes, podendo os incisivos centrais estarem associados. A prevalência dos estudos utilizados nesta revisão apontou a variância de 2,8% em Hong Kong a 40,2% na cidade do Rio de Janeiro. A etiologia desta alteração de esmalte ainda é imprecisa, mencionada como multifatorial, sendo os fatores pré-natais, perinatais e pós-natais frequentemente associados. A pesquisa realizada na Clínica Integrada Infantil da Faculdade Multivix avaliou o total de 302 crianças, com idade entre 5 a 14 anos, destas 66 (21,85%) possuíam HMI. Entre a amostra não houve diferença significativa entre os sexos e sem grande relevância na ligação entre doenças respiratórias e nascimento prematuro, sendo necessário mais estudos para definir a etiologia, e assim conseguir prevenir tal alteração.
FATORES ASSOCIADOS DA ATIVIDADE FÍSICA DE MODERADA A VIGOROSA, TEMPO SEDENTÁRIO, TEMPO DE TELA E ÍNDICE DE MASSA CORPORAL DE CRIANÇAS
Authors: Ferrari Gerson , De Victo Eduardo Rossato
Published: June 2021

Com a Terceira Revolução Industrial ou a também chamada Revolução Digital, ocorreu uma mudança significativa no ambiente e no estilo de vida, resultando na diminuição da atividade física, aumento do comportamento sedentário e da oferta de alimento. Diante disso, surge a necessidade de não só estudar os benefícios da atividade física para a saúde e prevenção de doença, como também, a necessidade de investigar os possíveis fatores associados a esses comportamentos. A atividade física de intensidade moderada vigorosa faz parte das recomendações da Organização Mundial da Saúde e entre os principais fatores associados a ela estão: o uso do transporte ativo, as aulas de educação física, a presença ou não de um dispositivo eletrônico no quarto e o tempo gasto ao ar livre e apoio social. O comportamento sedentário e o tempo de tela também estão sendo cada vez mais investigados e associados à outros fatores, como por exemplo, a adiposidade, raça/etnia, tempo de tela da mãe e padrão alimentar. Já o índice de massa corporal, no qual o nível individual pode explicar mais de 90%, também apresenta associações com o nível socioeconômico, Índice de Desenvolvimento Humano, causas genéticas e com o ambiente escolar e local. Os resultados apresentados mostram que para obter sucesso no desenvolvimento de uma sociedade mais ativa é necessário que se tenha esforços de todos os setores, incluindo ações dos pais e familiares, das escolas e professores, do bairro e vizinhança, além é claro, das políticas públicas advindas do governo.
ORÍGENES PARA O SÉCULO XXI?
Authors: Mendia Maria Cecília
Published: June 2021

Neste capítulo é reafirmada a intemporalidade das mensagens sagradas, a partir das considerações tanto de Karl Jaspers, quanto do próprio Orígenes. É apresentada a transcrição da V Homilia de Orígenes, “A saída dos filhos de Israel”, como referencial para a análise crítica do método de ensino de Orígenes com sua pedagogia alegórica, mística e ética. Em seguida, é feita uma leitura por meio da metodologia didática de Gabriel Perissé, como um auxílio hermenêutico, para compreender a mensagem de Orígenes, de acordo com a experiência e a visão de mundo de cada leitor.
O PROGRAMA BOLSA FAMÍLIA E SEUS IMPACTOS NO BAIRRO ANGARI EM JUAZEIRO - BA: UMA VISÃO A PARTIR DOS BENEFICIÁRIOS
Authors: Silva Bruno Cezar , Sodré Maria Lúcia da Silva
Published: June 2021

Diversos estudos concernentes à avaliação de programas sociais têm discutido a eficiência do Programa Bolsa Família no enfretamento à pobreza. É neste contexto que se insere este trabalho, que teve como objetivo a análise dos impactos socioeconômicos deste programa circunscritos ao Bairro do Angari no município de Juazeiro, Bahia, a partir da visão dos beneficiários do programa. O trabalho fez uma abordagem quali-quantitava e utilizou como técnicas de coleta de dados entrevistas semiestruturadas, observação em campo, somada à análise documental de relatórios institucionais. Trata-se de um trabalho descritivo realizado enquanto estratégia de investigação aplicada para avaliar os programas e políticas, a articulação dos programas de transferência de renda com a expansão e a democratização de serviços sociais básicos permitem auferir avanços para o combate à pobreza e desigualdade. Como resultado obtidos os beneficiários apontam o aumento de renda e acesso a bens de consumo e investimento e manutenção na educação das crianças, todavia, poucos avanços na infraestrutura social e acesso a outras fontes de emprego e renda e articulação por parte dos órgãos públicos para não dependência financeira ao Programa Bolsa Família.
CHINA: REFORMAS DOMÉSTICAS E INSERÇÃO GLOBAL - INOVAÇÕES INSTITUCIONAIS E DEPENDÊNCIA DA TRAJETÓRIA
Authors: Piragibe Clélia Virgínia Santos
Published: June 2021

Este artigo analisa a singularidade do padrão de desenvolvimento recente da República Popular da China, ao aplicar o conceito de dependência da trajetória na interpretação das transformações que vem ocorrendo há menos de um século no milenar “Império do Meio”. A investigação dos mecanismos causais do percurso recente chinês identifica os principais aspectos institucionais das reformas e abertura externa do país, desde o fim dos anos setenta. A opção pelo reformismo durante a conjunção crítica criou legados que permitiram à China tornar-se a “fábrica do mundo” e segundo poder econômico mundial. A (re) ascensão chinesa como potência emergente no Sistema Internacional põe em foco outros desafios à sua trajetória doméstica e externa, bem como pode acarretar riscos à legitimidade do Partido Comunista Chinês.
BR-OVT, STICKY BR-OVT E DOUBLE BR-OVT: POUCAS ADAPTAÇÕES, MÚLTIPLAS FUNCIONALIDADES
Authors: Xavier Morgana do Nascimento , Barbosa Rosângela Maria Rodrigues , Oliveira Cláudia Maria Fontes de
Published: June 2021

Culex quinquefasciatus e Aedes aegypti (Diptera: Culicidae) são insetos de grande importância para a saúde pública, pois estão envolvidos na veiculação de diferentes patógenos. Embora existam vacinas comercialmente disponíveis para a febre amarela e a dengue, novos casos destas doenças vêm sendo registrados. Além disso, apesar de existir tratamento medicamentoso para a filariose linfática, esta doença ainda não foi eliminada no Brasil. Dessa forma, o controle de culicídeos assume uma importância fundamental na redução do contato entre o patógeno e o homem. Nesse sentido, apresentamos o desenvolvimento de três armadilhas, que têm a capacidade de coletar mosquitos em diferentes fases do seu ciclo de vida - BROVT, Sticky BR-OVT e Double BR-OVT - e que podem contribuir com ações de vigilância e controle de culicídeos vetores. A primeira é uma armadilha de oviposição desenvolvida para a coleta de ovos de C. quinquefasciatus. A Sticky BR-OVT é um modelo de armadilha proveniente de adaptações da BR-OVT e que além de retirar ovos de C. quinquefasciatus do ambiente, também aprisiona os mosquitos adultos. A Double BR-OVT é uma armadilha que tem capacidade para coletar concomitantemente ovos e mosquitos adultos de C. quinquefasciatus e Aedes spp., o que pode gerar um importante retorno social, visto que agrega no mesmo instrumento a captura de duas espécies entomológicas de importância médica, em diferentes fases de seu ciclo vida. Estas armadilhas apresentam pequenas modificações entre si. Contudo, são sensíveis e eficazes ao que se propõem e por isso, podem ser facilmente empregadas em estratégias de vigilância entomológica.
A CANÇÃO “TERRA VERMELHA” DO GRUPO INDÍGENA DE RAP BRÔ MC´S: UM OLHAR DISCURSIVO PARA OS SENTIDOS SILENCIADOS DE ‘VIOLÊNCIA’ E ‘DISCRIMINAÇÃO’
Authors: Pires Anderson Aparecido , Limberti Rita de Cássia Aparecida Pacheco
Published: June 2021

O objetivo deste trabalho consiste em compreender, por meio da Análise do Discurso de linha francesa, os sentidos não ditos das palavras violência e discriminação, nas letras das músicas do grupo de rap Brô Mc’s, composto por jovens indígenas pertencentes às aldeias Jaguapiru e Bororó, situadas no município de Dourados, estado de Mato Grosso do Sul (MS), considerado o segundo estado com maior população indígena do Brasil. Pautados pelo conceito de linguagem pelo viés discursivo da Análise de Discurso, de que a palavra ultrapassa os limites daquilo que diz para significar e que assim, muitas vezes, atinge os sentidos daquilo que silencia, pretendemos, com base nos teóricos Orlandi (2011, 2012) e Pêcheux (2009) descobrir como a interpelação do indivíduo em sujeito pela ideologia faz com que o jovem indígena silencie palavras, como ‘violência’ e ‘discriminação’, e não as insira na canção intitulada “Terra Vermelha”. Considerando o contexto indígena de MS, pelo olhar de Costa e Nolasco (2013), Limberti (2012) e Nascimento (2013), sabe-se que problemas como a demarcação de terras, as péssimas condições de vida, os problemas com drogas e o alcoolismo estão presentes nas aldeias douradenses.
AVALIAÇÃO PRELIMINAR DA QUALIDADE DA ÁGUA SUBTERRÂNEA DA REGIÃO DE FEIRA DE SANTANA E MUNICÍPIOS LIMÍTROFES
Authors: Rios Israel Henrique Ribeiro , Santana Alexsandro Fiscina de
Published: June 2021

A avaliação da qualidade das águas subterrâneas é uma das importantes etapas que subsidia o enquadramento dos corpos d’água e auxilia no processo de gestão dos recursos hídricos. Analisar as condições de qualidade das águas é um procedimento importante para o efetivo gerenciamento das bacias hidrográficas, na medida em que mostra a situação atual para nortear metas e ações para alcançar uma situação almejada. Essa análise se dá através de parâmetros físicoquímicos e biológicos de qualidade. Alguns dos parâmetros mais importantes no âmbito de águas subterrâneas são cloreto, dureza, ferro, fluoreto, nitrato e sólidos dissolvidos totais. Este trabalho visa observar a qualidade da água dos aquíferos da região de Feira de Santana e municípios limítrofes no período de 2008 a 2018, através destes parâmetros citados acima. Para obtenção dos dados foi utilizada a plataforma SIAGAS - Sistema de Informações de Águas Subterrâneas do país. Foi observada uma porcentagem alta de pontos acima do limite da Portaria para os parâmetros dureza, cloreto e sólidos dissolvidos totais.
USO DE CYANOBACTERIA NO EIXO LESTE DO PROJETO DE INTEGRAÇÃO DO RIO SÃO FRANCISCO COMO BIOINDICADORA DA QUALIDADE DA ÁGUA PARA ABASTECIMENTO PÚBLICO
Authors: Cardoso Ariane Silva , Marques Érika Alves Tavares , Oliveira Cláudia Ricardo de , Sobral Maria do Carmo , Cunha Maristela Casé Costa
Published: June 2021

As características climáticas associadas à eutrofização das águas, na região semiárida no Nordeste brasileiro, afetam reservatórios utilizados para abastecimento humano. Essas condições propiciam o desenvolvimento das Cyanobacteria nos corpos hídricos. Neste sentido, as Cyanobacteria foram utilizadas como bioindicadoras da qualidade da água em trecho do Projeto de Integração do Rio São Francisco, na região do Alto Curso do Rio Paraíba – PB, a fim de contribuir com ações voltadas à qualidade da água utilizada para abastecimento público. Foi observada nos pontos amostrais a ocorrência de Cyanobacteria, tanto em altas densidades, indicando águas com altos níveis de nutrientes, como apresentando espécies potencialmente produtoras de cianotoxinas. Esses resultados evidenciam risco à saúde pública para as populações na área de estudo, e mostram que é imprescindível o constante monitoramento da qualidade da água, o tratamento adequado da água para abastecimento público e o controle do lançamento de esgotos e efluentes nos corpos hídricos integrantes do PISF.
AVALIAÇÃO DO POTENCIAL DE REÚSO NA AGRICULTURA DO PERMEADO PRODUZIDO EM UM BIORREATOR A MEMBRANA APLICADO AO TRATAMENTO DE EFLUENTES SANITÁRIOS
Authors: Gama Rafael Santos da , Miranda Yara Campos , Lapolli Flávio Rubens , Battistelli André Aguiar
Published: June 2021

A agricultura requer elevadas quantidades de água para irrigação, entretanto algumas regiões enfrentam um cenário de escassez hídrica, o que possibilita a utilização de águas residuária para a irrigação agrícola. Dessa forma, avaliou-se nesse estudo a potencialidade de reúso do permeado produzido em um biorreator a membrana (BRM) tratando efluentes sanitários. A fim de avaliar o potencial de uso do permeado produzido, os seguintes parâmetros foram analisados: turbidez, cor verdadeira, carbono orgânico dissolvido (COD) nitrogênio amoniacal (N-NH4 +), nitrito (N-NO2 - ), nitrato (N-NO3 - ), fosfato (P-PO4 3-), pH, coliformes totais (CT) e coliformes termotolerantes (Escherichia coli), com uma periodicidade de duas vezes por semana, durante 30 dias. O permeado produzido apresentou elevada qualidade em todos os parâmetros analisados, chegando a total remoção de microrganismos indicadores de contaminação fecal por bactérias, além da redução significativa da Turbidez, COD e Cor verdadeira, de 0,3 NTU, 28,8 mg/L1 e 45,6 Pt/Co respectivamente. Dessa forma, os resultados obtidos apresentam elevado potencial de reúso de água para irrigação agrícola, uma vez que o permeado produzido atende as normas especificadas pela United States Environmental Protection Agency (USEPA) e pelas legislações europeias. Porém, constata-se que a inexistência de legislações brasileiras para fins de reúso de água, dificulta sua aplicação na agricultura.
ANÁLISE TEMPORAL DO IMPACTO AMBIENTAL DA CONSTRUÇÃO DO ATERRO SANITÁRIO DE MARITUBA-PA
Authors: Costa Marcus Vinicius Zamorim da , Filho Alexandre Santos Fernandes , Barros Amanda Pamplona Leal , Craveiro Matheus do Rosário Marques , Corrêa Patrick Rafael Silva , Silva Rayssa Soares da , Cruz Salomão Silva da , Souza Samuel Salin Gonçalves de
Published: June 2021

O trabalho realizado tem o objetivo a análise cronológica a partir do ano de 2006 até 2017 do desenvolvimento da construção do aterro de Marituba, no estado do Pará e os impactos ambientais e sociais. O aterro sanitário é um dos meios mais ecológicos e criteriosos na disposição de Resíduos Sólidos Urbanos. O aterro de Marituba é um dos exemplos da mal gestão e construção, falhando no setor social e ambiental sendo punido judicialmente de acordo com o processo judicial instaurado no Inquérito Policial de n°. 40/2017.100116-5, proprietária da Central de Processamento e Tratamento de Resíduos Urbanos - CPTR Marituba, em razão das diversas denúncias, matérias jornalísticas e protestos realizados pela população em torno do aterro acerca do mau cheiro proveniente do lixo além de uma série de irregularidades, as quais evidenciaram o cometimento de diversos crimes ambientais, dentre os quais destaca-se a poluição atmosférica e hídrica.
O PAPEL DA EDUCAÇÃO AMBIENTAL NA GESTÃO DOS RESÍDUOS SÓLIDOS URBANOS
Authors: Framesche Leticia , Biluca Juliana , Schwind Leilane Talita Fatoreto
Published: June 2021

Em decorrência do aumento populacional, do consumo de bens e serviços, e consequentemente da excessiva geração e diversidade de Resíduos Sólidos Urbanos (RSU), as cidades brasileiras enfrentam dificuldades financeiras, estruturais, técnicas e ambientais para gerenciar adequadamente seus resíduos. Umas das ferramentas que possibilita melhorias no gerenciamento adequado dos resíduos e nos aspectos envolvendo a qualidade e quantidade dos resíduos é a educação ambiental. No processo investigativo não foram encontrados estudos que abordem simultaneamente a efetividade de ações de educação ambiental por meio de análises quali-quantitativas dos resíduos encaminhados à reciclagem, desta forma, o presente estudo visa preencher esta lacuna avaliando a evolução da quantidade e qualidade dos RSU em função de uma série de ações educativas envolvendo a sociedade e a comunidade escolar em uma cidade do estado do Paraná - Brasil. A sequência de atividades de educação ambiental foi aplicada em quatro bairros do município e em uma escola, sendo palestras, práticas pedagógicas intencionais, panfleto e instruções porta a porta. Após quatro meses, foi observado um aumento expressivo na quantidade de resíduos recicláveis encaminhada à cooperativa municipal, demonstrando que ações educativas e ambientais impactam positivamente na gestão dos resíduos sólidos, sendo, então, ferramentas eficazes aos gestores públicos no que tange melhorias sustentáveis no gerenciamento dos resíduos sólidos municipais.
What Roles Do Forgiveness and Reconciliation Play in Corporate Mediation?
Authors: Freeke Klaartje
Published: June 2021

What Roles Do Forgiveness and Reconciliation Play in Corporate Mediation?

The terms forgiveness and reconciliation are not the most frequently used words at the corporate mediation table. However, having been a conflict advisor and mediator for the last 17 years in both corporate and criminal cases, I know that the phenomena of forgiveness and reconciliation exist in all domains. Forgiveness can be found in everyday life, in small gestures and words. While researching this article, I spoke to three corporate mediators to find out what forgiveness and reconciliation look like in their fields of work, and it turns out that they might indeed be more present than one might think.
Is Suprascapular Nerve Block Better Than Intra-articular Corticosteroid Injection for the Treatment of Adhesive Capsulitis of the Shoulder? A Randomized Controlled Study
Authors: Haque Russel , Baruah Ranjit Kumar , Bari Abdul , Sawah Amjad
Published: June 2021

Background. Adhesive Capsulitis of shoulder (AdCS) is a treatment dilemma for surgeons. Intraarticular Corticosteroid Injection (IACI) has shown only short-term benefit in improving shoulder-related disability. Suprascapular nerve block (SSNB) has shown promise in trials in reducing chronic shoulder pain. Thus a RCT was conducted to compare the efficacy of SSNB versus IACI in the treatment of AdCS.
Material and methods. 86 patients with AdCS were divided into SSNB and IACI groups by block randomization. SSNB group received single Suprascapular Nerve Block with 10ml of 0.5% Bupivacaine while IACI group received single injection of 40mg Triamcinolone and 1ml 2% Lignocaine in the shoulder; both followed by physiotherapy and followed-up and evaluated with SPADI and modified Constant scores at 1, 6 and 12 weeks.
Results. Statistically significant improvements occurred in both groups. At 12 weeks, the SPADI and Con­stant score for SSNB improved to 9.62±10.07 and 36.95±3.43 respectively (p<0.001); and for IACI improved to 11.65±5.56 and 35.07±3.32 respectively (p <0.001). The difference in the scores between the 2 groups at 1st and 6th week was insignificant, but was statistically significant in favour of SSNB at 12 weeks (p=0.002).
Conclusions. 1. Thus, from the present study it can be concluded that both Suprascapular Nerve Block and Intra-articular Corticosteroid injection are effective mo­dalities of treatment for Adhesive Capsulitis of the shoulder. 2. Suprascapular Nerve Block increased patients’ pain tolerability for effective mobilization, the effect be­ing persistent even at 12 weeks following injection. 3. It was safer than Intra-articular Corticosteroid in­jection with less incidence of adverse effects in our study and the literature. 4. It is an easy-to-perform outpatient procedure, with minimal chance of infection and other complications. 5. In light of the above, we may recommend Su­prascapular Nerve Block as the initial procedure of choice in patients with Adhesive Capsulitis of Shoulder.
Rzeczywistość
wirtualna w architekturze – zastosowania i korzyści. Część 3.
Authors: Szuliński Tomasz
Published: June 2021

Artykuł jest kontynuacją dwóch tekstów opublikowanych w Builder Science. Autor opisuje tutaj zagadnienie związane
z autentycznym wykorzystaniem środowiska AR przy tworzeniu przestrzeni wirtualnych [7]. W dwóch poprzednich artykułach próbowano odpowiedzieć na pytanie, czy potrzebujemy wirtualnej rzeczywistości. W pierwszym artykule autor wraz ze współautorką przedstawił przykłady wykorzystania VR w budownictwie. Przeanalizowano również efekt wykorzystania tej technologii przez firmy deweloperskie, firmy związane z dystrybucją inteligentnych parkingów oraz inne przedsiębiorstwa. W tym artykule autor kontynuuje omówione zagadnienia związane z rozszerzoną rzeczywistością na przykładach branżowych. Przedstawione projekty różnią się stopniem zaawansowania zastosowanej technologii, grupą docelową oraz celami, które mają być osiągnięte dzięki zastosowaniu AR. Omawiane projekty zostały zrealizowane przez różne firmy, z którymi autor publikacji miał okazję mieć styczność. Ten artykuł powstał na podstawie własnych badań podczas pracy z zakresu VR i AR. W tekście wykorzystano własne obserwacje i wywiady z klientami, inwestorami oraz użytkownikami końcowymi.
„Der Staat ist von Verfassungs wegen nicht gehindert..."
Authors: van Ooyen Robert Chr. , Möllers Martin H. W.
Published: June 2021

A problematic ‘German constant’ can be observed in the Federal Constitutional Court: It is the ‘Staat’ (state) as a sovereign political entity. And it is the ‘Volk’ (people) as a homogeneous community. The Constitutional Court’s political theory—so the thesis goes—‘oscillates’ between a liberal and pluralistic conception of citizens, constitution and society and a national and identitarian form of statism. In this book, this is exemplified by:

the theories of constitution and democracy that are represented,

fundamental rights in relation to domestic security,

European integration,

foreign policy and

the emergency constitutional law as a result of 9/11 and the coronavirus pandemic
Chinese Politics
Authors: Noesselt Nele
Published: June 2021

China has undergone a rapid rise to global power status. All too often, however, China’s role in global politics is still analysed according to outdated categories and stereotypical classifications. This textbook introduces the reader to the foundations of Chinese state philosophy and political history, as well as to the one-party state’s basic institutional patterns and its recent transformations. It conducts a theory-based analysis of selected policy areas, while also discussing theories and concepts developed by leading Chinese political scientists. Beyond the Chinese one-party state, the textbook also reflects on the basic patterns of China’s two special administrative regions Hong Kong and Macao, and discusses the special case of Taiwan.

Testimonial“Much more than an ordinary textbook, Noesselt presents a comprehensive and dynamic analysis of Chinese political thinking, organization, and course of development. This is an original work of great insight, well grounded in China’s own discourse about politics. It well rewards a close reading.“
Brantly Womack (Professor of Foreign Affairs, University of Virginia)

"Noesselt shows how understanding China’s international behaviour and global aspirations requires both area-studies type in-depth knowledge of Chinese domestic politics and also international relations disciplinary expertise. Fortunately for the reader, she has both in abundance.“
Shaun Breslin (Professor of Politics and International Studies, University of Warwick)
Clostridioides difficile in Non-hospital Sources (Animals, Food, and Environment) in Asian Countries: A Literature Review
Authors: Esfandiari Zahra , Amani Fatemeh , Khavari Shokofeh , Sami Masoud
Published: June 2021

Context: Clostridioides difficile (C. difficile) is an agent responsible for severe infection with a high mortality rate in healthcare facilities. With the discovery of C. difficile in the community, it was assumed that this bacterium might be transmitted to humans through non-hospital sources. Evidence Acquisition: This study examined different aspects of the epidemiology of C. difficile in Asian countries with a review of the literature using search engines such as Web of Science, Scopus, and PubMed. Results: Based on the literature pertaining to Asia, the highest rate of C. difficile is found in samples collected from farm animals, red meat, and meat-based products. Two ribotypes 027 and 078, as hypervirulent factors, were found in different non-hospital sources. Resistance to the most frequently used antibiotics in healthcare setting was observed in C. difficile. Conclusions: Due to the heterogeneity of the examination of C. difficile, understanding the actual condition of C. difficile is difficult. However, the presence of two hypervirulent ribotypes of C. difficile in non-hospital sources is alarming. It seems that it is necessary to perform further studies on C. difficile in non-hospital sources. Defining a focal point for such research could be helpful to explore the situation of C. difficile in clinical settings and communities of Asian countries.
The planning and conducting transport and transport-sociological surveys for the development of a local project of the Belgorod urban agglomeration
Authors: Kushchenko Liliya , Kushchenko Sergey , Novikov Alexander , Novikov Ivan
Published: June 2021

When forming industrial and economic relations, there is a need for purposeful planning and development of urban agglomerations. The most urgent problem of spatial development of regions is due to the existing differences in the standard of living, conditions, as well as the scheme of the street and road network, namely, peripheral points. An important role in ensuring a high level of development of all the territories of the region is played by "group" forms of highly concentrated settlement, such as urban agglomerations. The development of urban agglomeration makes it possible to distribute industrial production, as well as rationally arrange them in relation to residential development, which will further improve economic and environmental indicators in large cities. In addition, an urban agglomeration that has significantly more opportunities for development is an environment that has properties favorable for inertial processes [6]. The article discusses the features of the formation of the urban agglomeration of the city of Belgorod. The territorial and functional structure of the urban agglomeration is presented. Priorities for the development of the urban agglomeration are outlined. The influence of the agglomeration effect on the economic growth of the region is revealed.
In situ resistance analysis of MgB2 formation process from Mg(BH4)2
Authors: Guo Chen , Cai Xin-Wei , Luo Wen-Hao , Huang Zi-Geng , Feng Qing-Rong , Gan Zi-Zhao ,   State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, Department of Physics, Peking University, Beijing 100871, China
Published: June 2021

Mg(BH4)2 was previously studied as a promising hydrogen storage material, because of its high gravimetric storage capacities for hydrogen and suitable thermodynamic properties. Mg(BH4)2 began to decompose at about 300 ℃, and formed MgB2 at the end of hydrogen desorption process with the weight content of 14.9% of hydrogen lost. Aside from the prominent hydrogen storage property, the decomposition process from Mg(BH4)2 to MgB2 can be a potential method for fabricating superconducting MgB2 at a low sintering temperature. In this paper, MgB2 bulk was prepared by an in-situ reaction, using the Mg(BH4)2 pressed block as a precursor. The resistance change of the sample was monitored during the Mg(BH4)2 decomposition process and the resistance-temperature (R-T) curve of this process was recorded. Phase of MgH2, Mg and B were formed as the block slowly release its hydrogen before MgB2 occurred. According to the R-T curve, the phase formation of MgB2 started in a relatively low temperature of 410 ℃. Because MgB2 was critically formed by Mg and B derived from Mg(BH4)2, we can compare our formation temperature with previous study on MgB2 prepared by Mg and B in different particle size. The fitting result indicated that the particle size of Mg and B harvest from Mg(BH4)2 decomposition was only 3.4 nm on average. The nearly atomic level mixture of Mg and B resulted in a high chemical reactivity, which was the main reason for low sintering temperature. X-ray diffraction results showed that the purity of MgB2 was 95.2%, and the size of MgB2 grains was 10–18 nm. SEM images showed that the MgB2 bulk had a porous structure and poor connectivity, which was caused by large amount the hydrogen release during the decomposition. MgB2 nanofibers can also be observed inside the bulk. In the superconductivity test, the superconducting transition temperature of the bulk was 35 K. After all, such in situ method to fabricate MgB2 showed a great advantage in some aspects, as its low-cost precursors, low sintering temperature, small grain-size and high superconducting transition temperature in the formed MgB2, which have the potential in industrial scale fabrication of MgB2 bulks and wires.
Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons
Authors: Ji Daisy X , Witt Kristen C , Kotov Dmitri I , Margolis Shally R , Louie Alexander , Chevée Victoria , Chen Katherine J , Gaidt Moritz M , Dhaliwal Harmandeep S , Lee Angus Y , Nishimura Stephen L , Zamboni Dario S , Kramnik Igor , Portnoy Daniel A , Darwin K Heran , Vance Russell E
Published: June 2021

Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. The Super susceptibility to tuberculosis 1 (Sst1) locus in mice confers resistance to diverse bacterial infections. Here we provide evidence that Sp140 is a gene encoded within the Sst1 locus that represses type I IFN transcription during bacterial infections. We generated Sp140–/– mice and found that they are susceptible to infection by Legionella pneumophila and Mycobacterium tuberculosis. Susceptibility of Sp140–/– mice to bacterial infection was rescued by crosses to mice lacking the type I IFN receptor (Ifnar–/–). Our results implicate Sp140 as an important negative regulator of type I IFNs that is essential for resistance to bacterial infections.
Molecular Cloning of Selected Regions of Catalytic Domain of CtsK Gene in Escherichia coli – A Feasibility Study
Authors: Madubashetha Hasanka , Cooray Ruwini , Wickramasinghe P. D. S. U. , Warnakula Lakshan , Silva Nimali De
Published: June 2021

Cathepsin K (CatK), encoded by CtsK gene in human, is involved in bone remodeling through ossification. The objective of the work conducted here was to express catalytic domains of CtsK gene in bacterial expression system as an initial step, facilitating recombinant production of human CatK for downstream applications in pharmacology. Four healthy human blood samples were collected. Genomic DNA was extracted using FlexiGene® whole blood DNA extraction kit. Upon quantification of DNA through NanodropTM spectrophotometer, sufficient quantity and quality was observed. CtsK gene was amplified by Polymerase Chain Reaction (PCR) using two pairs of primers tagged with restriction endonuclease sites of Sal1 and HindIII facilitating molecular cloning and visualized by Agarose Gel Electrophoresis (AGE). Two different bands of size 545bp and 265bp were observed. The bands were dissected and gel purified using GenaxxonTM gel purification kit and sequentially double digested by restriction enzymes; SalI and HindIII.  Vector PBS was also subjected to sequential double digestion using same enzymes and visualized via AGE. Double digested insert of size 265bp and vector were ligated using T4 DNA Ligase (all enzymes from PromegaTM). On another trail, ligation of the PCR product with band size 265bp to pGEM-TTM easy vector system (from PromegaTM) was also done and transformed to Top10 Escherichia coli competent cells for expression separately. Cells were grown in LB media in presence of XGAL, IPTG and Ampicillin and transformed cells were screened. In the restriction enzyme digestion and ligation setup, since the insert and vector were both double digested, it is confirmed that white colonies obtained were Escherichia coli cells were transformed with the desired recombinant vector and is therefore confirmatory. In the case of pGEM-TTM ligation, a colony PCR was done using the white colonies obtained and product size was confirmed via AGE. In conclusion, the objective of study was successfully achieved, by expressing a catalytic domain of CtsK. Developments and improvements could be made for expression of entire CatK gene and downstream production of the Cathepsin K protein for effective therapeutic purpose.
Effect of Hormonal Regime and Explant Type on Cell Clusters Expression of Maize Mutants (Zea Mays L) Derived from Gamma Irradiated Seeds of Ev8728 variety
Authors: Nadia Kanga Ahou , Koutoua Ayolié , Konan Yao Kouakou François , Angèle Kassi Amalan , Dogniméton Soro , Hilaire Kouakou Tano , Justin Kouadio Yatty
Published: June 2021

Maize (Zea mays L.) seeds irradiated with gamma or not from the fourth self-fertilisation cycle were selected for tissue culture. For this purpose, MS medium supplemented with 30 g.L-1 sucrose, 100 mg.L-1 casein hydrolysate, 100 mg.L-1 myo-inositol and 6 g.L-1 agar was used. For this purpose, three auxins type (2.4-dichlorophenoxyacetic acid (2.4-D), 2-methoxy-3.6-dichlorobenzoic acid (Dicamba) and Indole-3-Acetic Acid (AIA)) and explants (root, epicotyl and leaf) were tested. The results showed that 2.4-D more precisely at 3.5 mg.L-1 was the best auxin for callus induction in the different maize mutants studied. The induction rate, dry matter weight and water content of callus varied according to the type, age, explant position and the maize mutants studied (control, 200 and 300 grays). Thus, the 7-day root and more precisely its basal part was better for callogenesis. In addition, mutants of the 200 grays dose were more expressive in the ability to induce callus in EV8728maize variety.
Brief Study of the Immune System and A Large Sea of Pathogens and Other things Side A
Authors: Borges Valdecir de Godoy
Published: June 2021

And I will destroy any man who dares to abuse my trust, I promise that you will be mine (Queen 1973) We begin and brief study with this song to illustrate in a simple and interesting way because aimunology itself is something extremely interesting the flagship the captain this boat will be the book cell and molecular immunology by Abul K Abbas, Andrew H. Liichtman and Shiv Pllai we will start from a hypothetical situation of a region injured by a piercing instrument that penetrates the skin layers and skeletal muscle tissues based on this arrangement as we will discuss in this case DAMPs Molecular Patterns Associated with Damages and PAMPs molecular patterns associated with pathogens in this part of the study we stick to pathogens linked to amino acids and their formation in chains of proteins TH1 and TH2 that would be mechanisms of intracellular aggressions such as viruses and microbacteria and mechanisms that attack ectracellular cells like bacteria in the hypotonic situation ethics that we comment on an instrument any sharp drill when the layers of the cells the phosphopipidic layers are injured and all extracellular content moves to the extracellular medium begins with a response called innate or cellular that is given by immune cells intact as macrophages dendritic cells are very important in the presentation of phagocyte antigens also obviously to a perception of the central nervous system pain and a conscious state  this information reaches the cerebral cortex pain and is detected by nociceptors in response the central nervous system releases substance P in this initiation of injury the cells begins an inflammatory process and the damaged cell members these phospholipids generate the cascade of arachidonic acid in this process if this injury is resolved everything is solved with the first phase of defense which is the innate or cellular system in case of intra or intra pathogens extracellular remains and start m a process of aggression to the organism starts the second part of the defense that is acquired that has specific responses for extracellular and intra cellular pathogenic organisms the complementary immune system we did not address in this work this article is dedicated to my esteemed professors of the medical school São Judas Tadeu Cubatão
Oral Health: A Guide for Your Health as a Periodontist’s Point of View
Authors: Vadvadgi Vinay H. , Mani Amit , Padmawar Neeta S. , Harihar Lingraj
Published: June 2021

Dental caries and Periodontitis are the most commonly reported dental diseases. These can lead to loss of tooth structure and compromising the functions of teeth like mastication and thus affecting the overall health. Periodontitis is inflammation of periodontium resulting in loss of periodontal ligament attachment, bone destruction, tooth mobility and ultimately tooth loss. This is caused by the microorganisms present in the oral biofilm. One cubic millimeter of dental plaque contains about 100 million bacteria. At present almost more than 500-600 different varieties of bacteria have been identified in the oral cavity. Key perio-pathogens are the group of

perio-pathogens that are responsible for the commencement and progression of periodontal disease as well as failed periodontal therapy. A. actinomycetemcomitans, Tannerella forsythia and Porphyromonas gingivalis are the established key-pathogens in the various periodontal diseases. Through blood stream, these micro-organisms can be transported to various organs or system in the human body and causing and affecting overall health negatively. Endotoxins produced by these key perio-pathogens are associated with the non-oral diseases. It is a proven fact that periodontal health plays an important role in general health status in mankind. Periodontal pathogens can affect the systemic diseases and conditions adversely and can lead to unfavourable outcomes. Patients with cardiovascular diseases showed pathogens having same DNA as periodontal pathogens. In periodontitis patients, inflammatory mediators produced can trigger the hyperglycaemia. In pregnant women, premature birth and low birth weight is found linked with poor periodontal health. This paper highlights the role of periodontal health in various systemic diseases and conditions for better treatment planning and prevention of the adverse outcomes.