bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S6 from Complex Patterns of Genomic Heterogeneity Identified in 42 Tumor Samples and ctDNA of a Pulmonary Atypical Carcinoid Patient
Authors: Robb Tamsin J. , Tsai Peter , Fitzgerald Sandra , Shields Paula , Houseman Pascalene S. , Patel Rachna , Fan Vicky , Curran Ben , Tse Rexson , Ting Jacklyn , Kramer Nicole , Woodhouse Braden J. , Coats Esther , Le Quesne Stabej Polona , Reeve Jane , Parker Kate , Lawrence Ben , Blenkiron Cherie , Print Cristin G.
Published: April 2023

Supplementary Figure S6: ctDNA detection of private variants
While only four private variants were reported by the sequencing platform’s IonReporter software
(indicated in orange, key top right), there were sequencing reads to support other private variants.
Private variants unique to samples La1 (3 variants) and Pa6 (1 variant) were supported by 2 to 3 variant
molecules, and there was a single variant molecule detected to support private variant detection in the
following samples: Br2, Cr1, In2, Ki2, La1, Lh1, Lh2, Lu6, Lu7, Lu9, Pa2, Pa3, Pa6, Sc7, Th1, Th2, Ut1, Ve2,
Ve3.
Supplementary Figure S4 from Complex Patterns of Genomic Heterogeneity Identified in 42 Tumor Samples and ctDNA of a Pulmonary Atypical Carcinoid Patient
Authors: Robb Tamsin J. , Tsai Peter , Fitzgerald Sandra , Shields Paula , Houseman Pascalene S. , Patel Rachna , Fan Vicky , Curran Ben , Tse Rexson , Ting Jacklyn , Kramer Nicole , Woodhouse Braden J. , Coats Esther , Le Quesne Stabej Polona , Reeve Jane , Parker Kate , Lawrence Ben , Blenkiron Cherie , Print Cristin G.
Published: April 2023

Supplementary Figure S4: Absence of ARID1A variant in targeted panel sequencing of Biopsy 1
despite adequate depth Top panel shows Biopsy 1 targeted panel sequencing. Bottom panel shows representative tumor sampled at autopsy (Sc6) with heterozygous deletion in ARID1A, clearly absent from Biopsy 1
sequencing despite adequate depth (7240 unique molecules). The probability of not sampling the
ARID1A variant in Biopsy 1 due to chance alone was calculated assuming tumor cellularity of 80% and
the heterozygous ARID1A variant being present in 50% of tumor reads. 7240 unique molecules covered
this genomic position. The binomial distribution in R was used to calculate the probability of not
sampling this variant: dbinom(7240, size=7240, prob=0.6).
Movie S3 from Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer
Authors: Tucker John B. , Bonema Sarah C. , García-Varela Rebeca , Denu Ryan A. , Hu Yang , McGregor Stephanie M. , Burkard Mark E. , Weaver Beth A.
Published: April 2023

Lagging chromosome
Fig FS4 from Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer
Authors: Tucker John B. , Bonema Sarah C. , García-Varela Rebeca , Denu Ryan A. , Hu Yang , McGregor Stephanie M. , Burkard Mark E. , Weaver Beth A.
Published: April 2023

Figure S4. Misaligned chromosomes are the predominant mitotic error in breast cancer
organoids. A. Biopsies of primary breast cancer were grown in Matrigel suspension into
patient-derived organoids (PDOs), which were prepared for immunofluorescence and confocal
imaging. B. Representative images of mitotic cells with misaligned chromosomes observed in
PDOs. C. Frequency of mitotic defects assessed in PDOs from 10 patients. P values derived
from unpaired t-test.
Table TS6 from Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma
Authors: Wong Derek , Luo Ping , Znassi Nadia , Arteaga Diana P. , Gray Diana , Danesh Arnavaz , Han Ming , Zhao Eric Y. , Pedersen Stephanie , Prokopec Stephenie , Sundaravadanam Yogi , Torti Dax , Marsh Kayla , Keshavarzi Sareh , Xu Wei , Krema Hatem , Joshua Anthony M. , Butler Marcus O. , Pugh Trevor J.
Published: April 2023

regression statistics
Table TS4 from Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma
Authors: Wong Derek , Luo Ping , Znassi Nadia , Arteaga Diana P. , Gray Diana , Danesh Arnavaz , Han Ming , Zhao Eric Y. , Pedersen Stephanie , Prokopec Stephenie , Sundaravadanam Yogi , Torti Dax , Marsh Kayla , Keshavarzi Sareh , Xu Wei , Krema Hatem , Joshua Anthony M. , Butler Marcus O. , Pugh Trevor J.
Published: April 2023

mutations
Table TS2 from Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma
Authors: Wong Derek , Luo Ping , Znassi Nadia , Arteaga Diana P. , Gray Diana , Danesh Arnavaz , Han Ming , Zhao Eric Y. , Pedersen Stephanie , Prokopec Stephenie , Sundaravadanam Yogi , Torti Dax , Marsh Kayla , Keshavarzi Sareh , Xu Wei , Krema Hatem , Joshua Anthony M. , Butler Marcus O. , Pugh Trevor J.
Published: April 2023

sequencing coverage
Figure S2 from Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma
Authors: Wong Derek , Luo Ping , Znassi Nadia , Arteaga Diana P. , Gray Diana , Danesh Arnavaz , Han Ming , Zhao Eric Y. , Pedersen Stephanie , Prokopec Stephenie , Sundaravadanam Yogi , Torti Dax , Marsh Kayla , Keshavarzi Sareh , Xu Wei , Krema Hatem , Joshua Anthony M. , Butler Marcus O. , Pugh Trevor J.
Published: April 2023

Supplemental Figure 2
Supplementary Figures S1-3 from A PRRX1 Signature Identifies TIM-3 and VISTA as Potential Immune Checkpoint Targets in a Subgroup of Microsatellite Stable Colorectal Cancer Liver Metastases
Authors: Nygaard Vigdis , Ree Anne Hansen , Dagenborg Vegar Johansen , Børresen-Dale Anne-Lise , Edwin Bjørn , Fretland Åsmund Avdem , Grzyb Krzysztof , Haugen Mads H. , Mælandsmo Gunhild M. , Flatmark Kjersti
Published: April 2023

Figure S1. Gene expression heatmaps. Identification of an EMT/MES subgroup.

Figure S2. Validation of the PRRX1 signature in independent CLM data sets.

Figure S3. CRP measure in patient blood samples analyzed across PRRX1 subgroups.
Supplementary Methods SM1 from Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42
Authors: Medina Julia I. , Cruz-Collazo Ailed , Maldonado Maria del Mar , Matos Gascot Tatiana , Borrero-Garcia Luis D. , Cooke Mariana , Kazanietz Marcelo G. , Hernandez O'Farril Eliud , Vlaar Cornelis P. , Dharmawardhane Suranganie
Published: April 2023

Supplementary methods
Supplementary Movie 3 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Authors: Milutinovic Stefan , Abe Jun , Jones Emma , Kelch Inken , Smart Kathryn , Lauder Sarah N. , Somerville Michelle , Ware Carl , Godkin Andrew , Stein Jens V. , Bogle Gib , Gallimore Awen
Published: April 2023

Global overview of intra-tumoral HEVs in a 4T1 non-regressor tumour following PI-3065 treatment.
Table S4 from Elevated Dietary Carbohydrate and Glycemic Intake Associate with an Altered Oral Microbial Ecosystem in Two Large U.S. Cohorts
Authors: Monson Kelsey R. , Peters Brandilyn A. , Usyk Mykhaylo , Um Caroline Y. , Oberstein Paul E. , McCullough Marjorie L. , Purdue Mark P. , Freedman Neal D. , Hayes Richard B. , Ahn Jiyoung
Published: April 2023

Sensitivity analyses, beta diversity
Table S3 from Elevated Dietary Carbohydrate and Glycemic Intake Associate with an Altered Oral Microbial Ecosystem in Two Large U.S. Cohorts
Authors: Monson Kelsey R. , Peters Brandilyn A. , Usyk Mykhaylo , Um Caroline Y. , Oberstein Paul E. , McCullough Marjorie L. , Purdue Mark P. , Freedman Neal D. , Hayes Richard B. , Ahn Jiyoung
Published: April 2023

Sensitivity analyses, alpha diversity
Figure S2 from Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells
Authors: Milutinovic Stefan , Abe Jun , Jones Emma , Kelch Inken , Smart Kathryn , Lauder Sarah N. , Somerville Michelle , Ware Carl , Godkin Andrew , Stein Jens V. , Bogle Gib , Gallimore Awen
Published: April 2023

Naïve LN HEV Characterisation.
Chinese Expert Consensus on the Use of Biologics in Patients with Chronic Rhinosinusitis (2022, Zhuhai)
Authors: Hong Hai-yu , Chen Teng-yu , Yang Qin-tai , Sun Yue-qi , Chen Feng-hong , Lou Hong-fei , Wang Hong-tian , Yu Rui-li , An Yun-fang , Liu Feng , Wang Tian-sheng , Lu Mei-ping , Qiu Qian-hui , Wang Xiang-dong , Chen Jian-jun , Meng Cui-da , Xie Zhi-hai , Meng Juan , Zeng Ming , Xu Cheng-li , Wang Ying , Yang Yu-cheng , Zhang Wei-tian , Tang Jun , Yang Yan-li , Xu Rui , Yu Guo-dong , Shi Zhao-hui , Wei Xin , Ye Hui-ping , Sun Ya-nan , Yu Shao-qing , Zhang Tian-hong , Yong Jun , Hang Wei , Xu Yuan-teng , Xu Yu , Tan Guo-lin , Sun Na , Yang Gui , Li You-jin , Ye Jing , Zuo Ke-jun , Zhang Li-qiang , Wang Xue-yan , Yang An-ni , Xu Ying-xiang , Liao Wei , Fan Yun-ping , Li Hua-bin
Published: April 2023

Background: Chronic rhinosinusitis (CRS) is a common inflammatory disease in otolaryngology, mainly manifested as nasal congestion, nasal discharge, facial pain/pressure, and smell disorder. CRS with nasal polyps (CRSwNP), an important phenotype of CRS, has a high recurrence rate even after receiving corticosteroids and/or functional endoscopic sinus surgery. In recent years, clinicians have focused on the application of biological agents in CRSwNP. However, it has not reached a consensus on the timing and selection of biologics for the treatment of CRS so far. Summary: We reviewed the previous studies of biologics in CRS and summarized the indications, contraindications, efficacy assessment, prognosis, and adverse effects of biologics. Also, we evaluated the treatment response and adverse reactions of dupilumab, omalizumab, and mepolizumab in the management of CRS and made recommendations. Key Messages: Dupilumab, omalizumab, and mepolizumab have been approved for the treatment of CRSwNP by the US Food and Drug Administration. Type 2 and eosinophilic inflammation, need for systemic steroids or contraindication to systemic steroids, significantly impaired quality of life, anosmia, and comorbid asthma are required for the use of biologics. Based on current evidence, dupilumab has the prominent advantage in improving quality of life and reducing the risk of comorbid asthma in CRSwNP among the approved monoclonal antibodies. Most patients tolerate biological agents well in general with few major or severe adverse effects. Biologics have provided more options for severe uncontrolled CRSwNP patients or patients who refuse to have surgery. In the future, more novel biologics will be assessed in high-quality clinical trials and applied clinically.
Gastroduodenal Ulcers in Liver Transplant Recipients under Immunosuppressive Therapy
Authors: Kakizoe Kozue , Torisu Takehiro , Ihara Yutaro , Harada Noboru , Yoshizumi Tomoharu , Fujioka Shin , Kondo Masahiro , Kitazono Takanari
Published: April 2023

Introduction: The proportion of gastroduodenal ulcers caused by drugs is increasing. However, the risk of gastroduodenal ulcer from drugs other than nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin is unclear. An association between immunosuppressive drugs and gastroduodenal ulcers has been suggested. We aimed to identify the immunosuppressive drugs and clinical characteristics associated with gastroduodenal ulcers in post-liver transplant patients. Methods: The study investigated 119 patients who underwent esophagogastroduodenoscopy after liver transplantation, and 2 patients were excluded. Clinical characteristics, medications, and endoscopic images were retrospectively reviewed. Results: Among 117 post-living donor liver transplant recipients, gastroduodenal ulcers were found in 10 (9.2%) patients. The ulcer group had endoscopic gastritis more frequently (40%) compared with the non-ulcer group (10%). Logistic regression analysis revealed gastritis, NSAID use, and mycophenolate mofetil were risk factors in the post-liver transplant patients. Among 103 patients not on NSAIDs, 8 (7.8%) had peptic ulcer. The most common ulcer site and ulcer shape were the gastric antrum and a circular shape, respectively. All patients in the ulcer group were taking mycophenolate mofetil, which was the only immunosuppressive drug that showed a significant difference between the two groups. Five out of 8 ulcer patients (63%) were taking gastric acid suppressants, and gastroduodenal ulcers in post-liver transplant recipients were suggested to be refractory. Conclusion: Patients treated with immunosuppressive drugs after liver transplantation can develop gastroduodenal ulcers, even with gastric acid suppressant medication. Mycophenolate mofetil may increase the risk of gastroduodenal ulcers compared with other immunosuppressive drugs.
Measuring Room and Object Temperature Using MLX90614 Infrared Temperature Based on Arduino
Authors: Roza Liszulfah , Iman Haflan Nur , Nursabrina Fakhira , Nailufar Adila , Hidayah Ghina El , Sulaeman Ahmad Sofyan
Published: April 2023

Temperature measurement is needed in today's laboratory environment. Various sensors have been developed to meet these needs. One of them is an infrared temperature sensor that is used to measure temperature without the need to come into contact with the object whose temperature is to be measured, commonly called contactless. In the project we created, we used the MLX90614 infrared temperature sensor based on Arduino Uno to measure 2 objects alternately, the first is the ambient or room temperature and the second is body temperature. The measurement is carried out without touching and is 1–2 cm from the object being measured. The LCD will display the measurement output in real-time every second using ℃ units. The results of room temperature measurements that have been carried out with the MLX90614 infrared temperature sensor are compared with the results of digital hygrometer room temperature measurements while the results of body temperature measurements carried out with the MLX90614 infrared temperature sensor are compared with the results of thermo gun measurements.
The Founding Year of the Khitan Dynasty: A Textual Investigation Based on Primary Sources
Authors: Liu Pujiang
Published: April 2023

This article is an investigation into the founding of the Khitan empire based on a diverse collection of historical documents from both the Northern and Central Plains regions. These sources include the official history of the Liao dynasty, Liaoshi, written during the year of dynasty’s foundation in 907, the Qidan guo zhi from 916, as well as a variety of documents ranging from as early as the late 8th century to the mid 10th century. Some historians go as far as to say that Yelü Abaoji, who ruled the Liao dynasty from 907–926, never assumed the title of emperor. Although today’s scholarship on the Liao dynasty tends to fundamentally agree that Yelü Abaoji, who is known in history books as Taizu, the first emperor of the Liao dynasty, officially proclaimed the founding of the dynasty with himself as emperor in the first year of Shence in 916, no one has yet undertaken a proper investigation as to the details of the historical source material which has led to this assumption. This article is based on primary source research and investigates these critical pieces of historical evidence surrounding the founding of the Liao dynasty to better clarify events surrounding this major historical moment.
From the Enigma of Identity to “Becoming a Subject”: The Transitional Double
Authors: Jung Johann
Published: April 2023

In the field of psychopathology, “narcissistic and identity-related suffering” refers to a type of suffering characterized by a lack of being that centrally affects narcissism and identity continuity/discontinuity. Present in many clinical and psychopathological pictures, these problems in turn invite us to undertake a rereading of the modalities of structuration of subjectivity in the course of development. Elements for a model of identity construction are proposed based on the paradigm of the double. Approached from the angle of paradox, identity is thought of as a process in the service of “becoming a subject” based, essentially, on the role of the object and its reflexive function. Drawing on the concept of “transitional double,” this perspective allows the foundations of subjective identity and their stages of construction to be described; these foundations underlie the creation of an internal psychic mirror, the locus of one’s relationship to self. These considerations give us a better understanding of the logics of narcissistic and identity-related pathologies, which are characterized in particular by a failure of reflexive capacities, revealing the uncertainties of the dual relational dynamic in the course of early development.
Analyzing Competition in the Online Economy
Authors: Glass Victor , Tardiff Timothy
Published: April 2023

Since economic analysis of the workings of the online economy is in its early stages, detecting anticompetitive behavior remains challenging. There have been some insights from models that explain how two-sided markets work, but the practical uses of these models are limited thus far. More research is necessary on the definition and operations of platforms of different sizes and with different objectives, for example, the identification of data clustering and flows related to product clustering and information production and the relationships between data, information, and innovation. Furthermore, corporate culture, which can produce cultural clashes within an organization, may influence both (anti)competitive behavior and innovation. The cultural issue becomes even more complex when evaluating whether a merger would result in both innovation and the abuse of market power. This paper develops an overview of the technology and operations of the online economy as a start toward informing competition and antitrust policy. We present a technical overview that becomes a starting point for understanding potential areas of excessive market power. We also examine market dynamics from the large platforms’ points of view to understand where they believe the online economy is heading.
EQA: There’s not a glitch in the matrix. Investigation of CRP bias on the Roche Cobas c701
Authors: Stevenson Emma , Walsh Chelsey , Thomas Sadie
Published: April 2023

Background

The Roche Cobas c Tina-quant C-Reactive Protein (CRP) IV method has shown persistent, significant negative bias compared to other methodologies in the UK NEQAS external quality assurance (EQA) scheme. The aim of this study was to compare CRP concentrations determined by this restandardized 4th generation assay with another commercially available method to assess the extent of any bias and impact on clinical cut-offs.

Methods

CRP concentrations in 38 anonymized patient serum samples were determined by a particle-enhanced immunoturbidimetric assay on the Roche Cobas c701 module and a latex assay on the Beckman Coulter AU5800 analyser over a concentration range of 1–308 mg/L.

Results

97.4% samples analysed by the Roche Tina-quant CRP IV method demonstrated a negative bias compared to the Beckman AU latex method. The mean absolute bias was −4.12 mg/L (range: −19.13–10.93 mg/L; 95% CI: −17.25–9.01 mg/L). The mean relative difference was −15.5% (range: -40–4%; 95% CI: −33.03–1.94%). This bias was seen across the range of samples assayed, including at clinically significant cut-offs of 5 mg/L (−24% bias), 20 mg/L (−5%) and 100 mg/L (−13%).

Conclusion

The negative bias of the Roche method demonstrated in the EQA scheme appears to reflect genuine differences in patient results, rather than an EQA matrix effect, despite re-standardization of the CRP assay. This report indicates that clinical cut-offs and reference ranges may be method-dependent, which should be reflected in published guidance and interpretation provided by laboratories.
Bereavement and Professional Competencies: Exploring the Personal Experience of Death Among Nursing Students — A Qualitative Study
Authors: Tang Qianqian , Xu Tianmeng , Li Zhaoyu , Wang Mengmeng , Xu Lijie , Xu Gonglin , Yue Peng
Published: April 2023

Purpose: To explore the death experiences of nursing students in their personal lives. Methods: This study employed a qualitative descriptive design using the semi-structured interview approach. A purposive sampling method was used to recruit 24 nursing students from September 2020 to July 2022. Data were analyzed using Colaizzi’s analysis method. Lincoln and Guba’s criteria was used to evaluate the trustworthiness of the data. Results: Four main themes emerged from the interviews: (a) reactions to encounters with death; (b) adjustment strategies; (c) personal growth induced by the death experiences; and (d) professional reflections for preparing nurse role. Conclusions: Although the death of a loved one makes nursing students suffer from grief and emotional distress, we show that the experience promotes the personal growth and professional competencies of nursing students and thereby, developing their overall aptitude towards the profession. Death experiences of nursing students have shown to allow them to reflect on both life and death, to consider the demands of the nursing profession, and to provide foundation for nursing students to be more empathetic and compassionate when facing death in the future. Exploring death experiences of nursing students is vital in better providing better quality education and personal support for nursing students.
“Everybody Needs to Talk About Their Child”: A Descriptive Phenomenological Study of Bereaved Parents’ Experiences in Digital Storytelling
Authors: Rolbiecki Abigail J. , Washington Karla , Posley Kayla
Published: April 2023

Digital Storytelling (DS) is a narrative intervention that supports participants’ ability to find meaning in their life experiences – in this case, bereavement after child death. Thirteen ( N = 13) bereaved parents engaged in a DS workshop in which they created a story about the death of their child. Using a descriptive phenomenological approach, researchers explored participants’ experience with child death via their completed digital stories. Results highlight connection as a pathway to meaning making for bereaved parents who participate in DS, specifically in regard to connection with other bereaved parents and connection with their deceased child via telling their story.
“His Is a Reverent Vandalism”: Alain Locke’s Aesthetics and Fugitive Democracy
Authors: Rose Michelle K. L.
Published: April 2023

Several contemporary scholars have embraced the aesthetic resources in the Black Radical Tradition for the purpose of revitalizing the democratic project. Ironically, however, many drawn to the radical potential of fugitive escape are concerned about flight or exodus from the democratic project itself resulting in a defense of politics that constricts the possible benefits of fugitive aesthetics for democratic life. This article draws on the work of Alain Locke, a key figure of the Harlem Renaissance, to suggest another way in which we might follow Black fugitive aesthetics. Through an engagement with Locke, I theorize the notion of a fugitive bearing associated with a set of sensibilities that we might cultivate in order to approach the task of democratic transformation as a “reverent vandalism.” This article also challenges dismissive readings of Locke’s aestheticism by closely reexamining his commitment to expressive autonomy in connection with his theory of democracy. His “New Negro” avant-garde, like the fugitive, remains tethered to political life even while seeking a freedom that is unavailable within the strictures of the standing normative order.
Reflections on the Ideas, Paradigms, and Methodologies of China Studies: Philip C. C. Huang and Modern China
Authors: Liu Ping , Li Song , Tang Jiaman
Published: April 2023

Since its inception almost fifty years ago, Modern China has kept pace with international scholarly trends and greatly influenced global academia. As the founder and editor of Modern China, Philip C. C. Huang’s editorial principles, scholarly ideas, and personal theories and methodologies have been prominently embodied in the themes and contents of the journal, which has guided the development, evolution, and changing currents in the field of China studies. Reflecting back on the older methodologies of China studies, Huang abandoned the existing theoretical framework of either/or binaries and, basing himself firmly in empirical practice, pursued a new perspective focusing on the interrelationships and interpenetrations between dualities. Huang’s work has laid out the path for the future development of theory and practice in China studies.
Prophylactic bilateral internal iliac balloon occlusion to control hemorrhage in placenta accreta spectrum: a boon for obstetricians
Authors: Gambhir Mohit , Gamanagatti Shivanand , Sharma Raju , Manchanda Smita , Hemachandran Naren , Dadhwal Vatsla , Sharma JB
Published: April 2023

Background

Placenta accreta spectrum (PAS) is abnormal placental adhesion beyond superficial myometrium, which may lead to severe life-threatening hemorrhage requiring massive blood transfusions in the peripartum period. Prophylactic balloon catheterization of bilateral internal iliac arteries with or without additional embolization with Cesarean hysterectomy in patients with PAS prevent excessive intraoperative hemorrhage and may also obviate the need for hysterectomy.

Purpose

To study the efficacy of intervention radiological procedures in controlling intraoperative hemorrhage in patients with PAS.

Material and Methods

This ethically approved prospective study was conducted between November 2017 and October 2019 and written informed consent was obtained from all patients. Consecutive patients diagnosed with PAS during the antepartum period were evaluated. A total of 18 patients with PAS underwent prophylactic balloon catheterization of the bilateral internal iliac arteries followed by delivery of the infant. Interventional and intraoperative data of these patients were collected and compared with retrospectively collected data of patients (control group) who underwent hysterectomy without prophylactic balloon occlusion over the past four years (January 2016–November 2019).

Results

Significantly lower intraoperative blood loss (2.8 L vs. 4.7 L; P = 0.048) and pure red blood cell (PRBC) requirement ( P = 0.026) between patients who had hysterectomy with and without interventional radiological management was observed. Significantly higher blood loss ( P = 0.006) and fluid requirement ( P = 0.007) was observed with a higher degree of placental invasion. Only 1 (6%) major procedure-related complication was observed.

Conclusion

Interventional radiological procedures are effective in significantly reducing intraoperative blood loss and blood product requirement in patients with PAS.
Solitary metachronous adrenal metastasis after radical resection of gastric large cell neuroendocrine carcinoma: a case report and literature review
Authors: Qin Wuyao , Shang Jiwen , Cui Hao , Chang Zhi , Yang Shushang
Published: April 2023

Surgical resection is rarely employed for the treatment of metastatic gastric cancer, especially in patients with adrenal metastases, which usually indicate advanced systemic dissemination. Few published case reports have thus described the use of adrenalectomy for adrenal metastases from gastric cancer. In addition, most primary gastric malignancies are gastric adenocarcinomas, and gastric large cell neuroendocrine carcinoma (GLCNEC) is less common and has a poor prognosis. We report the case of a 71-year-old man who was diagnosed with solitary adrenal metastases 10 months after radical resection for GLCNEC and who was treated by adrenalectomy. He was followed-up for 9 months after adrenalectomy, with no further evidence of disease at his last follow-up examination. This case indicates that elective surgical resection may be feasible, even in rare cases of GLCNEC metastases to the adrenal glands, provided that the patient meets certain criteria, including solitary, metachronous tumors less than 4 cm.
Risk-taking under time-sensitivity in Sino-Pak negotiation in the context of the BRI project
Authors: Malik Tariq H. , Liang Qiusha , Zhao Yanzhi , Nielsen Klaus
Published: April 2023

China and Pakistan took part in the Belt and Road Initiative (BRI) project through CPEC (China–Pakistan Economic Corridor), but it faced many challenges at the negotiation and implementation stages. While their firms and individuals have come closer to exploring the scope and scales of opportunities, they have faced difficulties associated with uncertainty and time (risk-taking behaviour directly and indirectly through time sensitivity). Culturally, the potential differences in the risk orientation are plausible, but the contextualised differences in the negotiation process are not clear at the style level of analysis. This article explores whether how and why the negotiation style of China and Pakistan differs despite the visible values ahead of them. Based on postgraduate students in business schools, we investigated the notion of risk-taking orientation and moderation of the time sensitivity to both sides. The survey was based on 1398 participants: 917 (66%) Chinese and 481 (34%) Pakistani participants responded to risk-taking (low-high) and time sensitivity (low-high). The results are consistent across models. Directly, Chinese negotiators are more risk-takers than Pakistani negotiators. Indirectly, time-sensitive Chinese negotiators are low risk-takers than time-sensitive Pakistani negotiators. The study extends the risk orientation and time-sensitivity in perceptual assumptions in the cultural context.
Nutrition of School-Aged Children and Adolescents in Europe and Central Asia Region: A Literature and Survey Review
Authors: Mates Emily , Lelijveld Natasha , Ali Zakari , Sadler Kate , Yarparvar Amirhossein , Walters Tamsin , Brown Rebecca , Rodriques Basil
Published: April 2023

Background:

Middle childhood and adolescence are critical times for the growth, development, and establishment of healthy eating habits. The Europe and Central Asia (ECA) region has been through economic and nutrition transitions over the past 20 years, which are likely to have affected the nutritional status of this group.

Objective:

This review aimed to collate data on the nutritional status and dietary patterns of school-aged children (SAC) and adolescents (5-19 years) across the ECA region in order to inform policy and programming decisions.

Methods:

A systematic search of the literature in Pubmed, Cochrane, and ScienceDirect databases was conducted (April 2019), complemented by a systematic review of nationally representative surveys. Inclusion criteria were any data on micronutrient deficiencies, overweight, stunting, wasting, thinness, or dietary patterns in SAC and adolescents in the 21 UNICEF-defined countries of ECA, published since the year 2000.

Results:

Results included 134 published papers and 6 sources of survey data. The majority of studies were conducted in Turkey (56%), with all other countries having fewer than 10 studies each; 8 countries in the region having no studies on this age group at all. The most significant nutrition issue was overweight and obesity. Micronutrient deficiencies, particularly anemia, emerge as a further challenge. Dietary patterns were worse in urban areas and boys.

Conclusions:

The findings of this review suggest that there are 3 critical areas that need immediate attention: the promotion of healthy diets and physical activity to address high levels of overweight/obesity, anemia prevention efforts, and addressing the considerable data gaps for SAC and adolescent nutrition.
Objective and Subjective Stress among Grandparents Providing Assistive Regular Grandchild Care
Authors: Sowan Wafaa , Kochli-Hailovski Tal , Cohen Miri
Published: April 2023

Research on stress and coping has differentiated the effects of objective stress and subjective perceptions of stress on psychological and physical health, including in old age. This study examined the moderating role of social support in the relationship between objective and subjective stress with depressive and somatic symptoms in the context of Israeli grandparents. This cross-sectional study involved 243 grandparents who provided at least 5 hours a week of assistive regular care to their grandchildren, divided into lower and higher support groups. The results show that the levels of depressive and somatic symptoms were higher in the lower support group. Social support moderated the association between the intensity of care and perceived stress. Social support moderated the association between subjective stress and somatic symptoms. To conclude, the combination of high subjective stress and lower social support constitutes a risk factor for impaired psychological and physical health.
Administration and Scoring Errors on the Woodcock–Johnson IV Tests of Achievement: Before and During COVID-19
Authors: Lockwood Adam B. , Klatka Kelsey , Parker Brandon , Benson Nicholas
Published: April 2023

Eighty Woodcock–Johnson IV Tests of Achievement protocols from 40 test administrators were examined to determine the types and frequencies of administration and scoring errors made. Non-critical errors (e.g., failure to record verbatim) were found on every protocol ( M = 37.2). Critical (e.g., standard score, start point) errors were found on 98.8% of protocols ( M = 15.3). Additionally, a series of paired samples t-test were conducted to determine differences in total, critical, and non-critical errors pre- and during-COVID-19. No statistic differences were found. Our findings add to a growing body of research that suggests that errors on norm-referenced tests of achievement are pervasive. However, the frequency of errors did not appear to be affected by COVID-19 stressors or social distancing requirements. Implications of these findings for training and practice are discussed. Suggestions for future research are also provided.
A Standardized, 3-Tiered, Seizure Burden–Based Protocol for the Treatment of Neonatal Seizures
Authors: Moeller Ashley A. , Stefanescu Andrei R. , Stefanescu Beatrice M. , Golomb Meredith R. , Boyle Frances A. , Buss William F. , Rose Rebecca S. , Wing Sarah E.
Published: April 2023

Objective

To evaluate use of a standardized, 3-tiered, seizure burden-based protocol for treatment of all electroencephalography (EEG)-confirmed seizures in a level IV neonatal intensive care unit (NICU).

Study Design

All infants admitted to the NICU with EEG-confirmed seizures over a 25-month period were enrolled in the study. We compared short-term outcomes before and after implementation of a standardized, 3-tiered protocol.

Results

A total of 107 infants were enrolled in the study. Use of midazolam infusions was reduced by 53.7% ( p  = 0.02). Midazolam infusion duration increased from 4 to 7.5 days ( p = 0.003); however, when excluding 3 outliers, there was no significant difference between groups (­ p  = 0.67). Duration of EEG monitoring decreased from 5 to 3 days ( p  = 0.005). Hospital length of stay was unchanged.

Conclusion

Implementation of a standardized, 3-tiered protocol for treatment of neonatal seizures improved short-term outcomes. Although not measured directly, reductions in EEG duration and midazolam use are promising indicators of overall seizure burden. More research is needed to evaluate impact on long-term neurodevelopmental outcomes.
Insomnia in the Veteran Population: A Sleep Health and Wellness Intervention
Authors: DeBellis Joy E. , Ellison Kathy Jo , McMillan Libba , Duffey John
Published: April 2023

The purpose of this evidence-based project (EBP) was to determine if an evidence-based sleep health and wellness intervention improved sleep in veterans self-reporting a history of insomnia. Insomnia can negatively affect an individual's physical and psychological well-being, as well as increase health-care costs and decrease the overall quality of life. The intervention utilized a combination of insomnia treatments, delivered to two American Legion veteran participant groups: an Alabama American Legion Retreat and individuals at an American Legion Post site. The holistic-focused modalities used in this intervention included Cognitive Behavioral Therapy for Insomnia (CBT-I) techniques, sleep hygiene principles, and Complementary and Alternative Medicine (CAM) methods. The measurement tool, the Insomnia Severity Index (ISI), indicated statistically significant changes in the severity of participants’ self-reported insomnia. Based upon the research evidence and results of the pre- and post-test ISI, a more permanent, ongoing sleep health and wellness intervention is feasible and would have numerous beneficial effects for the veteran's management of insomnia symptoms. Future efforts include implementing sleep hygiene, CAM interventions, and holistic nursing-supported education interventions at other sites and venues within the Alabama American Legion, as well as maintaining long-term community partnerships with veteran groups such as the Alabama American Legion.
Physician leadership during the current crisis in healthcare: A perspective drawn from anthropological and clinical leadership research
Authors: Looi Jeffrey C L , Allison Stephen , Kisely Stephen R , Bastiampillai Tarun
Published: April 2023

Objectives

There are ongoing challenges in workforce sustainability and service delivery due to the COVID-19 pandemic. Recruiting credible clinical leaders can enhance outcomes through mentoring, leading by example, and creating positive work environments. We investigate the anthropology of, and related research on leadership.

Conclusions

Clinical and anthropological research provides strong grounds for investing in clinical leadership. The stability of ‘prestige-based’ leadership can be contrasted with the outcomes of ‘dominance-based’ leadership that relies on force, control, and threats. Dominance-based leadership increases the risks of bullying in stressed healthcare organisations. In contrast, expert clinical leaders can exert culturally mediated effects on social learning, team cooperation and morale, and patient outcomes.
Beyond boundaries: The present and future of 4E cognitive science in interdisciplinary academia, industry, and everyday life
Authors: Tavassoli Samira , Montoya Morgan , Ishihara Ken
Published: April 2023

What gives a scientific framework a place among laypeople? Can cognitive science change human livelihood? How can cognitive science research extend beyond the bounds of its own field to change academia and society? These are precisely the kinds of questions the 2022 Workshop on “Challenges in 4E Cognition and the Opportunities They Present” sought to address. The workshop gathered an interdisciplinary cohort of researchers from philosophy, psychology, cognitive science, neuroscience, and artificial intelligence to discuss the future of 4E (embodied, embedded, enacted, and extended) cognition research in and outside of Japan. The aim was to identify the most prominent fields in which 4E research is taking place, such as 4E in relation to artificial life, human–computer interfaces, and phenomenology. We strived to articulate the most important open questions in these fields, and understand how adopting a 4E perspective may yield unique ways of answering them, as well as novel avenues of long-term interdisciplinary collaboration. We then discussed how the 4E framework may embed itself as a point of connection between the social and biological sciences, and bridge the gap between academia, medicine, and policymaking, to inform how humans conduct research, think about ourselves, and live life. In this report, we summarize the topics of discussion, the insights garnered, and the practical methods used to ignite discussions and collaborations amongst the researchers in attendance, as a model for future workshops with similar aims.
Urinary Bladder “Melanosis”: A Case Report and Review of the Literature
Authors: Cao Qi , Goldenberg Mitchell , Aron Manju , Wang Tiannan
Published: April 2023

Melanosis of the urinary bladder, so-called melanosis vesicae, is a rare condition characterized by dark, velvety bladder mucosa observed by cystoscopy examination. Up to 20 examples have been reported in the English literature, and the etiology of this disease still needs to be discovered. We present an 82-year-old woman with a history of pelvic organ prolapse-associated urinary symptoms. The patient was found to have pigmented urinary bladder mucosa on cystoscopy and underwent a total hysterectomy and bladder mucosal biopsy. Histologically, pigmented granules were evident in the bladder stroma and epithelium, highlighted by Periodic Acid-Schiff (PAS) stain, suggestive of lipofuscin in nature. We outline the diagnostic features of bladder melanosis, discuss the diagnostic mimickers, and thoroughly review the literature on the subject.
Quality of Life in Breast Cancer Patients: A Systematic Review of the Qualitative Studies
Authors: Heidary Zohreh , Ghaemi Marjan , Hossein Rashidi Batool , Kohandel Gargari Omid , Montazeri Ali
Published: April 2023

Objective

Quality of life (QoL) in breast cancer patients is still an important topic. Despite numerous quantitative scales, qualitative studies can help to in-depth understand the QoL of breast cancer patients. The purpose of this systematic review was to integrate qualitative studies on the QoL of women with breast cancer.

Methods

A literature search was performed in electronic databases including PubMed, Scopus, and Web of Science from January 1, 2010 until June 28, 2022 to find out qualitative studies assessing breast cancer patient’s QoL. Two authors independently evaluated methodological quality according to the consolidated criteria for reporting qualitative research (COREQ) checklist. Data were extracted and reported by themes for cancer-free women and patients with metastatic cancer separately.

Results

In all, 1565 citations were retrieved. After removing 1387 duplicate and irrelevant papers, the full texts of 27 articles were reviewed and finally, 9 were eligible for evaluation. In quality checking of the citations, all articles gained the required quality score. After examining and merging similar topics, nine major themes were extracted. Physical, spiritual, and psychological aspects of QoL were the common issues in cancer-free women (before and after the COVID-19 pandemic) and patients with metastatic cancer. Perception of cancer and social life were the other main concerns in cancer-free women, whereas, in metastatic patients’ overall survival and planning for the future and their children’s life was the focus of interest. Women with metastatic disease showed more vulnerability in coping compared to cancer-free women.

Conclusion

This review provides an opportunity to have a closer look into the several domains of QoL in women with breast cancer. In-depth information provided by this review might help to develop interventions for patients and their families to support women to cope much better with their life challenges.
Good, Bad, and Hopefully Not the God Trick: Technological Systems in Qualitative Inquiry
Authors: Naomi Nordstrom Susan
Published: April 2023

This article is a tangle of threads made possible by theoretical and practical snags in my work with qualitative inquiry technology. One snag pulls at the term “technology” and its etymology to think about technology as a creative system used in the production of knowledge. That snag leads to a study of early anthropological work and technology to better understand the history that feeds into qualitative inquiry. And another snag considers who and what is involved in the making of technological tools used in research. These unraveling snags entangle together to consider technology as an open-ended system consisting of a variety of tools used to create political, cultural, and social realities. Such thinking offers a space to contemplate how technological advances have shaped qualitative inquiry’s past, present, and future. The forceful snags studied in this article begin to ask the question, “Can we think of qualitative inquiry without technology?”
Anti-cancer therapeutic agents and carpal tunnel syndrome: Clinical, electrodiagnostic, and ultrasound findings in seven patients
Authors: Shields Lisa BE , Iyer Vasudeva G , Zhang Yi Ping , Shields Christopher B
Published: April 2023

Introduction

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and rarely develops after drug therapy. This study describes the clinical, electrodiagnostic (EDX), and ultrasound (US) findings in seven patients who experienced CTS due to anti-cancer therapeutic agents.

Methods

All patients underwent EDX testing, and four patients had an US study.

Results

CTS occurred in four patients with aromatase inhibitors, two with immune checkpoint inhibitors, and one with a selective estrogen receptor modulator. The mean duration between initiation of the anti-cancer therapeutic agents and symptom onset was 6 weeks (range: 2–12 weeks). Decreased digit sensation was noted in all patients; wasting and weakness of the abductor pollicis brevis (APB) was observed in three (42.8%) patients. The compound muscle action potentials (CMAP) of the APB and sensory nerve action potentials of the second or third digit could not be recorded in two (28.5%) and four (57.1%) patients, respectively. The needle EMG detected fibrillations and positive sharp waves in the APB in two patients. The motor unit potentials of the APB were decreased with large polyphasics in three (42.8%) patients. Of the four patients who underwent US testing, all had increased cross-sectional area of the median nerve at the carpal tunnel inlet, three (75%) had thenar muscle atrophy, and two (50%) had a loss of fascicular pattern. Three (42.8%) patients underwent a CTR.

Conclusions

Physicians should be cognizant of the relationship between anti-cancer therapeutic agents and CTS. EDX studies and US play important roles in the diagnostic assessment of such patients.
“To be Good as a Manager”: Masculinities and Everyday Life Within Transnational Corporations in Colombia and Ecuador
Authors: Sánchez Voelkl Pilar
Published: April 2023

This article examines the role of homosociality in the definition of power hierarchies within transnational corporations and the ways by which these firms control the sexual life of their managers to preserve patriarchy. It is based on the ethnographic research that I carried out to study masculinities among corporate elites in Colombia and Ecuador. More than being a good manager, to be good as a manager requires to perform traditional codes of masculinity, to actively participate in male homosocial rituals, and to act both as a sexualized, desirable, heterosexual man and as an exemplary father for the corporate family.