bluuebunny/crossref_metadata_2025 huggingface dataset:
Bingöl İl Merkezinde Taşkın Risk Alanlarının Coğrafi Bilgi Sistemleri ile Belirlenmesi
Authors: ÇELİKER Murat , NACAR KOÇER Nilüfer , YILDIZ Osman
Published: June 2020

Taşkın, ülkemizde en sık görülen doğal afetler arasında yer almaktadır. Bu nedenle, taşkın yayılım alanlarının önceden belirlenmesi, taşkın riskinin azaltılması ve buna bağlı olarak can ve mal güvenliğinin sağlanması açısından çok önemlidir. Bu çalışmada, Coğrafi Bilgi Sistemleri (CBS) ve HEC-RAS yardımıyla Bingöl İl merkezinden geçen Çapakçur, Gayt ve Göynük çaylarının kent içerisinde oluşturacağı taşkın su derinliklerinin ve yayılım alanlarının belirlenmesi amaçlanmıştır. Bunun için, sentetik birim hidrograflardan elde edilen 2, 5, 10, 25, 50, 100, 500 ve 1.000 yıllık tekerrür sürelerine ait taşkın pik debileri kullanılarak HEC-RAS ile bu derelerin il merkezinden geçen kısımlarının hidrolik modellemeleri yapılmıştır. İl merkezine ait 1/1.000 ölçekli hali hazır haritalardan elde edilen verilerin modele tanımlanması ArcGIS üzerinde çalışan HEC-GeoRAS ile gerçekleştirilmiştir. HEC-RAS yardımıyla elde edilen hidrolik model sonuçlarına göre CBS ortamında hazırlanan taşkın yayılım haritalarında, göz önüne alınan taşkın debilerinin sebep olduğu maksimum su derinliğinin 8,12–9,62 m, su yayılım alanının ise 635.402- 1.561.982 m2 arasında değiştiği görülmüştür. Elde edilen bu taşkın yayılım haritaları, bölgenin ileriye yönelik yerleşim ve kalkınma planları için önemli bir veri kaynağı niteliği taşımaktadır.
Recent Computational Studies on Mechanisms of Hypervalent Iodine(III)-Promoted Dearomatization of Phenols
Authors: Zheng Hanliang , Xue Xiao-Song
Published: June 2020

Hypervalent iodine-promoted dearomatization of phenols has received intense
attention. This mini-review summarizes recent computational mechanistic studies of phenolic
dearomatizations promoted by hypervalent iodine(III) reagents or catalysts. The first part
of this review describes mechanisms of racemic dearomatization of phenols, paying special
attention to the associative and dissociative pathways. The second part focuses on mechanisms
and selectivities of diastereo- or enantio-selective dearomatization of phenols.
Strong Association between Serotonin Transporter 5-HTTVNTR Variant and Psychoactive Substance (Nicotine) Use in the Turkish Cypriot Population
Authors: Kandemis Emine , Tuncel Gulten , Asut Ozen , Temel Sehime G. , Ergoren Mahmut C.
Published: June 2020

Background:

The use of psychoactive substances is one of the most dangerous social problems worldwide. Nicotine dependence results from the interaction between neurobiological, environmental and genetic factors. Serotonin is a neurotransmitter that has a wide range of central nervous system activities. The serotonin transporter gene has been previously linked to psychological traits.

Objective:

A variable number of tandem repeats within the serotonin transporter-linked polymorphic gene region are believed to alter the transcriptional efficiency of the 5-HTT gene. Therefore, we aimed to investigate the association between this polymorphic site and smoking behavior in the Turkish Cypriot population.

Methods:

A total of 259 (100 smokers, 100 non-smokers and 59 ex-smokers) Turkish Cypriots were included in this population-based cross-sectional study. Genomic DNA was extracted from peripheral blood samples and the 5-HTTVNTR2 polymorphisms were determined by the PCR-RFLP.

Results:

The allelic frequency and genotype distribution results of this study showed a strong association (P<0.0001) between smokers and non-smokers. No statistical significance was found between non-smokers and ex-smokers.

Conclusion:

This is the first genetic epidemiology study to investigate the allelic frequencies of 5-HTTVNTR2 polymorphisms associated with smoking behavior in the Turkish Cypriot population. Based on the results of this study, genome-wide association studies should be designed for preventive medicine in this population.
2020 FDA Drug-drug Interaction Guidance: A Comparison Analysis and Action Plan by Pharmaceutical Industrial Scientists
Authors: Sudsakorn Sirimas , Bahadduri Praveen , Fretland Jennifer , Lu Chuang
Published: June 2020

Background:

In January 2020, the US FDA published two final guidelines, one entitled “In vitro Drug
Interaction Studies - Cytochrome P450 Enzyme- and Transporter-Mediated Drug Interactions Guidance for Industry”
and the other entitled “Clinical Drug Interaction Studies - Cytochrome P450 Enzyme- and Transporter-Mediated
Drug Interactions Guidance for Industry”. These were updated from the 2017 draft in vitro and clinical DDI
guidance.

Methods:

This study is aimed to provide an analysis of the updates along with a comparison of the DDI guidelines
published by the European Medicines Agency (EMA) and Japanese Pharmaceuticals and Medical Devices Agency
(PMDA) along with the current literature.

Results:

The updates were provided in the final FDA DDI guidelines and explained the rationale of those changes
based on the understanding from research and literature. Furthermore, a comparison among the FDA, EMA, and
PMDA DDI guidelines are presented in Tables 1, 2 and 3.

Conclusion:

The new 2020 clinical DDI guidance from the FDA now has even higher harmonization with the
guidance (or guidelines) from the EMA and PMDA. A comparison of DDI guidance from the FDA 2017, 2020,
EMA, and PMDA on CYP and transporter based DDI, mathematical models, PBPK, and clinical evaluation of DDI
is presented in this review.
Monocyclic β-Lactam: A Review on Synthesis and Potential Biological Activities of a Multitarget Core
Authors: Leite Taíse H.O. , Saraiva Mauricio F. , Pinheiro Alessandra C. , de Souza Marcus Vinícius N.
Published: June 2020

A monocyclic ring in their structure characterizes monobactams, a subclass of β-lactam antibiotics.
Many of these compounds have a bactericidal mechanism of action and acts as penicillin and
cephalosporins, interfering with bacterial cell wall biosynthesis. The synthesis of novel β-lactams is an
emerging area of organic synthesis research due to the problem of increasing bacterial resistance to
existing β -lactam antibiotics, and, in this way, new compounds have been presented with several
structural modifications, aiming to improve biological activities. Among the biological activities
studied, the most outstanding are antibacterial, antitubercular, anticholesterolemic, anticancer, antiinflammatory,
antiviral, and anti-enzymatic, among others. This review explores the vast number of
works related to monocyclic β-lactams, compounds of great importance in scientific research.
Effective Pharmacophore for CDC25 Phosphatases Enzyme Inhibitors: Newly Synthesized Bromothiazolopyrimidine Derivatives
Authors: El-Shahat Mahmoud , Salama Mowafia. A.M. , El-Farargy Ahmed F. , Ali Mamdouh M. , Ahmed Dalia M.
Published: June 2020

Background:

Thiazolopyrimidine analogues are versatile synthetic scaffold possessing wide
spectrum of biological interests involving potential anticancer activity.

Objective:

To report the synthesis of novel bromothiazolopyrimidine derivatives and the study of both
molecular modeling and in-vitro anticancer activity.

Methods:

Novel bromothiazolopyrimidine derivatives 5-18 have been prepared from 2-bromo-3-(4-
chlorophenyl)-1-(3,4-dimethylphenyl)-propenone 3 as a key starting compound. The anti-cancer activities
of the new compounds were evaluated against HepG2, MCF-7, A549 and HCT116 cell lines.

Results:

The compounds 16, 17 and 18 showed cytotoxic and growth inhibitory activities on both
colon and lung cells. The cytotoxic activities of the novel synthetic compounds 8, 9, 11, 16, 17 and 18
were due to CDC25 phosphatases inhibition as shown by the enzymatic binding assay. Although compounds
8, 9 and 11 have only demonstrated CDC25B phosphatases inhibition.

Conclusion:

The novel bromothiazolopyrimidine derivatives showed promising in vitro anticancer
activities against colon cancer HCT116 and lung cancer A549 cell lines comparable to the anticancer
drug doxorubicin.
The Functional Role of Long Non-coding RNA UCA1 in Human Multiple Cancers: a Review Study
Authors: Hosseini Nashmin Fayazi , Manoochehri Hamed , Khoei Saeideh Gholamzadeh , Sheykhhasan Mohsen
Published: June 2020

In various cancers, high-grade tumor and poor survival rate in patients with
upregulated lncRNAs UCA1 have been confirmed. Urothelial carcinoma associated 1
(UCA1) is an oncogenic non-coding RNA with a length of more than 200 nucleotides.
The UCA1 regulate critical biological processes that are involved in cancer progression,
including cancer cell growth, invasion, migration, metastasis, and angiogenesis. So It
should not surprise that UCA1 overexpresses in variety of cancers type, including
pancreatic cancer, ovarian cancer, gastric cancer, colorectal cancer, breast cancer,
prostate cancer, endometrial cancer, cervical cancer, bladder cancer, adrenal cancer,
hypopharyngeal cancer, oral cancer, gallbladder cancer, nasopharyngeal cancer,
laryngeal cancer, osteosarcoma, esophageal squamous cell carcinoma, renal cell
carcinoma, cholangiocarcinoma, leukemia, glioma, thyroid cancer, medulloblastoma,
hepatocellular carcinoma and multiple myeloma. In this article, we review the biological
function and regulatory mechanism of UCA1 in several cancers and also, we will discuss
the potential of its as cancer biomarker and cancer treatment.
The Roles of Alternative Splicing in Tumor-immune Cell Interactions
Authors: Wang Yue , Zhang Honglei , Jiao Baowei , Nie Jianyun , Li Xiyin , Wang Wenhuan , Wang Hairui
Published: June 2020

Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide
neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated
tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms
involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and protumoral
roles in different types of cancer. For example, ULBP1_RI, MLL5Δ21spe, NKp44-1Δ5,
MHC-IΔ7, CD200SΔ1, 2, PVR α/β/γ/δ and IL-33 variants 1/2/3 act as regulators in solid tumors and
IPAK4-L and, FOXP1ΔN100 exhibit functions in hematological cancers.
Crosstalk between Inflammation and the BBB in Stroke
Authors: Huang Yuyou , Chen Shengpan , Luo Yumin , Han Ziping
Published: June 2020

The blood-brain barrier (BBB), which is located at the interface between the central
nervous system (CNS) and the circulatory system, is instrumental in establishing and maintaining
the microenvironmental homeostasis of the CNS. BBB disruption following stroke promotes inflammation
by enabling leukocytes, T cells and other immune cells to migrate via both the paracellular
and transcellular routes across the BBB and to infiltrate the CNS parenchyma. Leukocytes
promote the removal of necrotic tissues and neuronal recovery, but they also aggravate BBB injury
and exacerbate stroke outcomes, especially after late reperfusion. Moreover, the swelling of astrocyte
endfeet is thought to contribute to the ‘no-reflow’ phenomenon observed after cerebral ischemia,
that is, blood flow cannot return to capillaries after recanalization of large blood vessels. Pericyte
recruitment and subsequent coverage of endothelial cells (ECs) alleviate BBB disruption,
which causes the transmigration of inflammatory cells across the BBB to be a dynamic process.
Furthermore, interneurons and perivascular microglia also make contacts with ECs, astrocytes and
pericytes to establish the neurovascular unit. BBB-derived factors after cerebral ischemia triggered
microglial activation. During the later stage of injury, microglia remain associated with brain ECs
and contribute to repair mechanisms, including postinjury angiogenesis, by acquiring a protective
phenotype, which possibly occurs through the release of microglia-derived soluble factors. Taken
together, we reviewed dynamic and bidirectional crosstalk between inflammation and the BBB
during stroke and revealed targeted interventions based on the crosstalk between inflammation and
the BBB, which will provide novel insights for developing new therapeutic strategies.
The New NNRTI ACC007 Combined with Lamivudine and Tenofovir Disoproxil Fumarate Show Synergy Anti-HIV Activity In Vitro
Authors: Huang Xu-Sheng , Luo Rong-Hua , Hu Xiong-Lin , Chen Huan , Xiang Si-Ying , Tang Cheng-Run , Zhang Chun-Tao , Shen Xiao-Ning , Zheng Yong-Tang
Published: June 2020

Background:

Acquired immunodeficiency syndrome can hardly be cured currently and
people with human immunodeficiency virus (HIV) need lifelong treatment that may result in the
emergence of drug resistance which leads to failed treatment. Thus, the development of new anti-
HIV drugs and new treatment regimens are necessary.

Objective:

The aim of this study is to analyze the combined anti-HIV activity of tenofovir disoproxil
fumarate, lamivudine and ACC007, a new non-nucleoside reverse transcriptase inhibitor.

Methods:

The antiviral activity of tenofovir disoproxil fumarate, lamivudine and ACC007 alone or
in combination against different HIV-1 strains was determined by the detection of HIV-1 p24 level
through enzyme-linked immunosorbent assay.

Result:

ACC007 showed EC50 of nanomolar range (from 3.03 nM to 252.59 nM) against all HIV-1
strains used in this study except the HIV-1A17, with EC50 of 1.57 μM. The combined antiviral activity
of ACC007, lamivudine and tenofovir disoproxil fumarate showed synergy antiviral activity
against all HIV-1 strains used in this study. The three-drug combination showed moderate synergism
against HIV-1A17, HIV-14755-5, HIV-1K103N and HIV-1V106M, with a combination index value
ranging from 0.71 to 0.87, and showed synergism against the other HIV-1 strains with combination
index value from 0.35 to 0.67. The combination with ACC007 significantly increases the dose reduction
index value of lamivudine and tenofovir disoproxil fumarate, compared with two-drug
combination.

Conclusion:

ACC007 exhibits potent antiviral activity alone or with 3TC and TDF, and exerts synergistic
effect against all HIV strains used in our investigation in vitro.
Indol-2-Carboxylic Acid Esters Containing N-Phenylpiperazine Moiety - Preparation and Cholinesterase-inhibiting Activity
Authors: Padrtová Tereza , Marvanová Pavlína , Kubínová Renáta , Csöllei Jozef , Farsa Oldřich , Goněc Tomáš , Odehnalová Klára , Opatřilová Radka , Pazourek Jiří , Sychrová Alice , Šmejkal Karel , Mokrý Petr
Published: June 2020

Background:

The indole derivatives and the N-phenylpiperazine fragment represent interesting
molecular moieties suitable for the research of new potentially biologically active compounds. This study was
undertaken to identify if indol-2-carboxylic acid esters containing N-phenylpiperazine moiety possess
acetylcholinesterase and butyrylcholinesterase inhibitory activity.

Materials and Methods:

The study dealt with the synthesis of a novel series of analogs of 1H-indole-2-
carboxylic acid and 3-methyl-1H-indole-2-carboxylic acid. The structure of the derivatives was represented by
the indolylcarbonyloxyaminopropanol skeleton with the attached N-phenylpiperazine or diethylamine moiety,
which formed a basic part of the molecule. The final products were synthesized as dihydrochloride salts, fumaric
acid salts, and quaternary ammonium salts. The first step of the synthetic pathway led to the preparation of esters
of 1H-indole-2-carboxylic acid from the commercially available 1H-indole-2-carboxylic acid. The Fischer indole
synthesis was used to synthesize derivatives of 3-methyl-1H-indole-2-carboxylic acid.

Results and Discussion:

Final 18 indolylcarbonyloxyaminopropanols in the form of dihydrochlorides, fumarates,
and quaternary ammonium salts were prepared using various optimization ways. The very efficient way for the
formation of 3-methyl-1H-indole-2-carboxylate (Fischer indole cyclization product) was the one-pot synthesis of
phenylhydrazine with methyl 2-oxobutanoate with acetic acid and sulphuric acid as catalysts.

Conclusion:

Most of the derivatives comprised of an attached N-phenylpiperazine group, which formed a basic
part of the molecule and in which the phenyl ring was substituted in position C-2 or C-4. The synthesized
compounds were subjected to cholinesterase-inhibiting activity evaluation, by modified Ellman method.
Quaternary ammonium salt of 1H-indole-2-carboxylic acid which contain N-phenylpiperazine fragment with
nitro group in position C-4 (7c) demonstrated the most potent activity against acetylcholinesterase.
Electrochemical Oxidative Esterification of Thiophenols: Efficient Access to Sulfinic Esters
Authors: Yang Chun-Hui , Wu Cheng , Zhang Jun-Ming , Tao Xiang-Zhang , Xu Jun , Dai Jian-Jun , Xu Hua-Jian
Published: June 2020

Background:

The sulfinic esters are important and useful building blocks in organic synthesis.

Objective:

The aim of this study was to develop a simple and efficient method for the synthesis of sulfinic esters.

Materials and Methods:

Constant current electrolysis from thiols and alcohols was selected as the method for the
synthesis of sulfinic esters.

Results and Discussion:

A novel electrochemical method for the synthesis of sulfinic esters from thiophenols and
alcohols has been developed. Up to 27 examples of sulfinic esters have been synthesized using the current methods.
This protocol shows good functional group tolerance as well as high efficiency. In addition, this protocol can be easily
scaled up with good efficiency. Notably, heterocycle-containing substrates, including pyridine, thiophene, and
benzothiazole, gave the desired products in good yields. A plausible reaction mechanism is proposed.

Conclusion:

This research not only provides a green and efficient method for the synthesis of sulfinic esters but
also shows new applications of electrochemistry in organic synthesis. It is considered that this green and efficient
synthetic protocol used to prepare sulfinic esters will have good applications in the future.
Telematics Healthcare Through Digital Terrestrial Television Networks: Applications and Perspectives
Authors: Kardaras Konstantinos , Lambrou George I. , Koutsouris Dimitrios
Published: June 2020

Background:

The trend nowadays is the interconnection of rural health centers with a specialized
monitoring medical center.

Aim:

The paper investigates the qualitative and quantitative characteristics that degrade the perceived video
picture quality for a variety of short MPEG-4 video clips.

Methods:

In the present work our approach was considered in three branches; first the customization of video
quality in terms of video and data compression, so maximum quality is achieved, second the use of the optimized
video data transfer for emergency situations and third the subsequent creation of a “virtual doctor”.

Results:

Further on, novel architectures will be suggested in order to achieve the creation of a broadcasting
network for healthcare telematics. Remote medical supervision and healthcare treatment will be provided to
remote patients in rural health centers and understaffed areas that lack telemetry infrastructures and medical
expertise personnel.

Conclusions:

The proposed architecture, along with the optimized data transmission, demonstrates the
integration of present and forthcoming telecommunication network technologies enabling remote interactivity
for fixed, portable and mobile users.
Molecular Docking, Physicochemical Properties, Pharmacokinetics and Toxicity of Flavonoids Present in Euterpe oleracea Martius
Authors: de Oliveira Nayana Keyla Seabra , Almeida Marcos Rafael Silva , Pontes Franco Márcio Maciel , Barcelos Mariana Pegrucci , Silva Guilherme Martins , de Paula da Silva Carlos Henrique Tomich , Cruz Rodrigo Alves Soares , da Silva Hage-Melim Lorane Izabel
Published: June 2020

Background:

Euterpe oleracea Martius, popularly known as açaí, is a fruit rich in α-
tocopherols, fibers, lipids, mineral ions, and polyphenols. It is believed that the high content of polyphenols,
especially flavonoids, provides several health-promoting effects to the açaí fruit, including
anti-inflammatory, immunomodulatory, antinociceptive and antioxidant properties. Most of the
flavonoids are antioxidant molecules of plant origin that act as a trap for free radicals, reacting and
neutralizing them, thus offering perspectives in preventing oxidative damage.

Objective:

In this study, we aim to perform an in silico evaluation of flavonoids present in the pulp
and the oil of Euterpe oleracea Martius, evaluating their potential to serve as antioxidant agents.

Methods:

Firstly, we selected 16 flavonoids present in Euterpe oleracea Martius pulp and oil, and
then their physicochemical properties were analyzed concerning the Lipinski’s Rule of Five. Moreover,
we evaluated their pharmacokinetic properties using the QikProp module of the Schrödinger
software as well as their toxicity profile, using the DEREK software. Docking simulations, using
the GOLD 4.1 software, as well as pharmacophoric hypotheses calculation of molecules were also
performed.

Results:

Flavonoids present in the açaí pulp including catechin, epicatechin, luteolin, chrisoeriol,
taxifolin, apigenin, dihydrokaempferol, isovitexin, and vitexin presented good oral bioavailability.
Regarding the pharmacokinetic properties, the compounds catechin, epicatechin, isovitexin, luteolin,
chrisoeriol, taxifolin, and isorhamnetin rutinoside presented the best results, besides high human
oral absorption. Regarding the prediction of toxicological properties, compounds isorhamnetin
rutinoside and rutin presented mutagenicity for hydroxynaphthalene or derivate, and regarding the
docking simulations, all the compounds investigated in this study presented key interactions with
the corresponding targets.

Conclusion:

The flavonoids catechin, chrysoeriol, and taxifolin presented the best results according
to the evaluation conducted in this study. These computational results can be used as a theoretical
basis for future studies concerning the development of drug candidates, as well as to enlighten biological
tests in vitro and in vivo, which can contribute to the treatment of neurodegenerative diseases,
such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Development and Validation of a Robust HPLC Method for Simultaneous Estimation of 5-Fluorouracil and Resveratrol and its Application in the Engineered Nanostructured Lipid Carrier
Authors: Iqubal Mohammad Kashif , Kamal Abid , Iqubal Ashif , Imran Mohammad , Ali Javed , Baboota Sanjula
Published: June 2020

Background:

5-fluorouracil and resveratrol are the two most effective anticancer drugs.
Combination therapy with these two drugs has shown promising results in cancer. The formulation
containing 5-fluorouracil and resveratrol has been prepared, but no analytical method is available in
the literature for their simultaneous estimation. However, several analytical methods are there for estimation
of either 5-fluorouracil or resveratrol alone. Therefore, the present article is designed for the
simultaneous estimation of 5-fluorouracil and resveratrol by HPLC and its application in the quantification
of the drugs present in the formulated nanostructured lipid carrier (NLC).

Methods:

The method was developed using a C18 column (Purospher® STAR RP-18 endcapped (5
μm) Hibar® RT 250-4.6) with acetonitrile and water as the mobile phase (25:75 v/v) and estimated at
272 nm. The currently developed method was further validated by the ICH guideline Q2 (R1). Combinatorial
NLC of 5-fluorouracil and resveratrol was also prepared and characterized.

Results:

The LOD and LOQ were 8.22 and 24.91 μg mL-1 and 6.58 and 19.93 μg mL-1, respectively.
The precision was under the acceptable limits of <2% RSD. The content of 5-fluorouracil and
resveratrol in NLC were found to be 99.452% and 96.421%, respectively.

Conclusion:

The findings showed that the developed and validated method was simple, fast, costeffective,
and reproducible for the simultaneous estimation of both the drugs in the same formulation.
Antigene and Antiproliferative Effects of Triplex-Forming Oligonucleotide (TFO) Targeted on hmgb1 Gene in Human Hepatoma Cells
Authors: Lohani Neelam , Rajeswari Moganty R.
Published: June 2020

Background:

The high mobility group box 1 (hmgb1) is one of the frequently over-expressed genes
whose aberrant expression is reported in a number of human cancers. Various strategies are underway to inhibit
hmgb1 expression in cancer cells having considerable therapeutic value.

Objective:

The present work involves selective transcriptional inhibition of the hmgb1 gene using selective DNA
triplex structure-based gene technology. Here, the promoter region of the hmgb1 gene at position (-183 to -165) from
the transcription start site as a target was selected using bioinformatic tools.

Methods:

The DNA triplex formation by the DNA of the target gene and TFO was confirmed using UV absorption
spectroscopy, Circular Dichroism, and Isothermal Calorimetry.

Results:

Treatment of HepG2 cell with specific Triplex-forming Oligonucleotide significantly downregulated
HMGB1 expression level at mRNA and protein levels by 50%, while the classical anticancer drugs, actinomycin/
adriamycin as positive controls showed 65% and the combination of TFO and drug decreased by 70%. The
anti-proliferative effects of TFO correlated well with the fact of accumulation of cells in the Go phase and apoptotic
cell death. Further, the binding of anti-cancer drugs to hmgb1 is stronger in DNA triplex state as compared
to hmgb1 alone, suggesting the combination therapy as a better option.

Conclusion:

Therefore, the ability of hmgb1 targeted triplex-forming oligonucleotide in combination with triplex
selective anticancer drug holds promise in the treatment of malignancies associated with hmgb1 overexpression.
The result obtained may open up new vistas to provide a basis for the rational drug design and searching
for high-affinity ligands with a high triplex selectivity.
Updates on Receptors Targeted by Heterocyclic Scaffolds: New Horizon in Anticancer Drug Development
Authors: Kharb Rajeev
Published: June 2020

Anticancer is a high priority research area for scientists as cancer is one of the leading causes of death
globally. It is pertinent to mention here that conventional anticancer drugs such as methotrexate, vincristine,
cyclophosphamide, etoposide, doxorubicin, cisplatin, etc. are not much efficient for the treatment of different
types of cancer; also these suffer from serious side effects leading to therapy failure. A large variety of cancerrelated
receptors such as carbonic anhydrase, tyrosine kinase, topoisomerase, protein kinase, histone deacetylase,
etc. have been identified which can be targeted by anticancer drugs. Heterocycles like oxadiazole, thiazole,
thiadiazole, indole, pyridine, pyrimidine, benzimidazole, etc. play a pivotal role in modern medicinal chemistry
because they have a broad spectrum of pharmacological activities including prominent anticancer activity.
Therefore, it was considered significant to explore heterocyclic compounds reported in recent most literature
which can bind effectively with the cancer-related receptors. This will not only provide a targeted approach to
deal with cancer but also the safety profile of the drugs can be further improved. The information provided in
this manuscript may be found useful for the design and development of anticancer drugs.
Co-Existence of Sarcoidosis and Sjögren’s Syndrome with Hypercalcemia and Renal Involvement: A Case Report and Literature Review
Authors: Xu Jing , Yang Yumei , Chen Dandan , Lu Zhiqiang , Ge Junbo , Li Xiaomu , Gao Xin
Published: June 2020

Background:

Sarcoidosis and Sjögren's syndrome (SS) are chronic multi-system
inflammatory diseases of unknown origin that most commonly attack the salivary glands. Both of the
diseases have vague and non-specific symptoms, causing difficulties for the clinicians to distinguish
between the two diseases. Main diagnostic criteria of SS exclude sarcoidosis. However, a co-existence
of both diseases should be noted. Here, a case of co-existing sarcoidosis and Sjögren's syndrome is
reported, complicated with severe hypercalcemia and renal failure, in addition to a literature review.

Case Report:

A 71-year-old man visited our hospital complaining of daily progressive oral dryness,
thirst, and blurred vision with a feeling of dry eyes for a one-year duration. His physical examination
showed enlargement of both sides of cervical and supraclavicular lymph nodes. Lung auscultation
showed decreased breath sounds with bibasilar inspiratory crackles. However, initial laboratory results
revealed severe hypercalcemia with moderate hypercalciuria and renal failure. The final diagnosis was
co-existing SS and sarcoidosis according to clinical, radiological, and laboratory data. The patient received
oral prednisone therapy for 18 months. After a follow-up of years, the serum calcium concentration,
renal function, and chest CT scan remained normal after prednisone treatment stopped for more
than 18 months.

Conclusion:

In the literature, calcium metabolic disorder and renal involvement have not been reported among patients with Sarcoidosis and Sjögren's syndrome, suggesting that calcium metabolic
disorder may be underestimated. Serum and urine calcium concentration should be measured in addition to routine laboratory tests.
Emerging Therapeutic Effects of Herbal Plants in Rheumatoid Arthritis
Authors: Makkar Rashita , Behl Tapan , Kumar Arun , Nijhawan Priya , Arora Sandeep
Published: June 2020

Rheumatoid arthritis is a chronic inflammatory autoimmune disease characterized by the
failure of spontaneous resolution of inflammation with lifetime perseverance, becoming one of the
major causes of disability in millions of people. It is mainly characterized by progressive erosion of
cartilage in response to the formation of pannus leading to chronic polyarthritis and joint distortion.
Early diagnosis and advances in molecular biology undoubtedly revolutionized therapeutic interventions
in the past decade for better disease management. Despite favorable prospects, many patients still
fail to respond to the current therapies urging a burning need to develop newer and safer medications.
Herbal plants have been utilized since the ancient era and provided the base for massive bioactive
compounds with flaunting therapeutic potential, many being advanced to drugs that are consumed
worldwide for treating countless ailments. Scientific studies showed the involvement of several cellular
mechanisms like oxidative stress suppression, downregulated synthesis of proinflammatory cytokines
namely interleukins (IL-1, IL-6), TNF-α, NF-κB, demoted metalloproteinases induced cartilage destruction
and augmentation of free radical scavenging and antioxidant activity in the treatment of
rheumatoid arthritis. A plethora of active phytoconstituents like flavonoids, saponins, terpenes, alkaloids,
lactones, etc, have been isolated from herbal plants with proven curative actions. The present
review enlists some of the herbal drugs that can be used to amend the effects of rheumatoid arthritis
and impart symptomatic relief to patients.
A Review on Expedient Assets of Polymers Employed in Novel Topical Formulation for Successful Treatment of Arthritis
Authors: Nishal Suchitra , Jhawat Vikas , Phaugat Parmita
Published: June 2020

Background:

Rheumatoid arthritis (RA) is an autoimmune ailment where the body's defense
system is violated by damaging its joints. In RA treatment strategies, attempts have been
made for oral, topical, and parenteral formulations with different drugs, but none of the formulations
could be regarded as the perfect dosage form. In the current review, the meticulous discussion
has been made on the suitability of novel topical formulations in the treatment of RA. Moreover,
the emphasis has been made on activities of biodegradable polymers such as hyaluronic acid,
lecithin, pluronic acid, chitosan, human serum albumin (HSA), and polylactide glycolic acid (PLGA)
as well as their role in the management of RA.

Objective:

The study aimed to apprehend the role of polymeric materials in developing an ideal topical
drug delivery system that can bestow targeted delivery, enhanced penetration of drugs, improved
stability of the formulation, and improved PKPD profile of the drugs.

:

These polymers possess twofold functions, primarily by increasing skin penetration and secondarily
by improving joint mobility and cartilage regeneration. Furthermore, biocompatibility and
biodegradability are features that increase the use of the aforementioned polymers.

Results:

The significant role of all the polymers in improving the conditions of bones and joints
suffering from rheumatoid arthritis has been demonstrated by various studies.
Inventario y mapeo de variables forestales mediante sensores remotos en el estado de Quintana Roo, México
Authors: Hernández-Ramos Jonathan , García-Cuevas Xavier , Peréz-Miranda Ramiro , González-Hernández Antonio , Martínez-Ángel Luis
Published: June 2020

Los sensores remotos en combinación con información derivada de los inventarios forestales estiman variables de interés con precisión y bajo costo. El objetivo de este trabajo fue estimar el área basal (AB), volumen maderable (VTA) y biomasa aérea (B) en diferentes ecosistemas de selvas mediante información Landsat ETM+ e Inventario Nacional Forestal y de Suelos (INFyS) en Quintana Roo, México. Se generó una matriz de correlación entre datos del INFyS e información espectral, posteriormente, un modelo de regresión lineal múltiple. Con las ecuaciones seleccionadas se generaron mapas de distribución espacial de AB (m2 ha-1), VTA (m3 ha-1) y B (Mg ha-1). El inventario total se estimó mediante tres enfoques: i) estimadores de razón (ERaz), ii) estimadores de regresión (EReg) y iii) estimadores del muestreo simple al azar. Los dos primeros enfoques corresponden al inventario alternativo mediante sensores remotos y el tercero al inventario tradicional. El coeficiente de correlación resultó mayor del índice de diferencia normalizada con 0.35, 0.39 y 0.39 para AB, VTA y B. Los modelos de regresión presentaron coeficientes de determinación ajustada de 0.28, 0.32 y 0.32 para estimar AB, VTA y B, respectivamente. Los tres estimadores son estadísticamente diferentes y muestran que el EReg es el más conservador y con precisión en AB, VTA y B de 2.73%, 2.92% y 2.71%, respectivamente, además de intervalos de confianza de menor amplitud que el MSA y ERaz. Con la actualización del inventario mediante sensores remotos se mejora el proceso de evaluación de los recursos forestales y su planificación.
Ensayos de tensión y flexión en raíces de dos especies tropicales
Authors: Valdés-Rodríguez Ofelia Andrea , Jimenez Alonso Ángel Eduardo , Servín Martínez Alberto , Tejero-Andrade José
Published: June 2020

Las raíces de las plantas permiten evitar la pérdida del suelo al formar mallas que lo retienen, especialmente en suelos arenosos debido a la poca cohesión de estos sustratos; sin embargo, la literatura técnica sobre la ejecución de las pruebas para caracterizar raíces es escasa, por lo que se requiere documentar su caracterización. Los objetivos de este trabajo fueron documentar y caracterizar las propiedades mecánicas de dos raíces de especies tropicales mediante pruebas de tensión y flexión. Para ello se diseñaron dispositivos especiales para sujetar raíces de Jatropha curcas L. y Ricinus communis L. extraídas de suelos arenosos. Las raíces se sometieron a pruebas de tensión y flexión y se estimaron sus módulos de Young en tensión, así como los esfuerzos máximos de flexión. Los módulos de Young en tensión obtenidos variaron en intervalos de 6.27 MPa a 334 MPa para R. comunis y de 4.56 MPa a 271 MPa para J. curcas, con diámetros entre 0.5 mm y 6.8 mm para ambas especies; en las pruebas de flexión las raíces nunca alcanzaron el punto de ruptura, pero los esfuerzos máximos registrados fueron de 21 MPa y 28 MPa, para Ricinus y Jatropha, respectivamente. Se concluye que las raíces de Jatropha y Ricinus poseen módulos de elasticidad muy bajos, similares a otras raíces de especies herbáceas y arbóreas, con una muy alta flexibilidad y comparables con las propiedades del polietileno de baja densidad.
Reintegración de la Fábrica a la Ciudad , a través del Parasitismo y la Regeneración Urbana
Authors: Andica Pérez Luis Felipe , García Lozano Andrés Mauricio
Published: June 2020

El artículo responde a la pregunta: ¿Cómo reintegrar la Fábrica a un Sistema de Ciudad? Como lugar de estudio se estableció la Zona Industrial de La Tebaida, Quindío. La metodología parte de un análisis cualitativo del lugar y una búsqueda de herramientas que conceptualicen un modelo de transformación urbana. Se establecen los conceptos de Parasitismo y Regeneración Urbana, como instrumentos que permiten reinterpretar el espacio y función de la Fábrica en torno a las dinámicas urbanas. Los resultados determinan un modelo urbano conceptual, en el cual se recicla la Fábrica y se le otorga valor, permitiendo que haga parte del sistema vivo de ciudad.
Pseudoxanthoma-like papillary dermal elastolysis: A case report (Preprint)
Authors: Kim Jason Ho Seung , Jenkins Jr Donald
Published: June 2020

UNSTRUCTURED

An 88-year old female presented with axillary lesions on both sides that have developed over a year. She has been asymptomatic, but it was causing cosmetic concerns. There was no significant medical history and she was not taking any medications. Physical exam showed 1-6mm firm yellow dermal papules scattered over the axillae. Initial differential diagnoses included Fox-Fordyce disease and sebaceous cysts. First skin biopsy showed perivascular lymphocytes, extravasated red cells, and skin atrophy thought to be within the normal range expected of an elderly patient. There was some loss of elastic fibres within papillary dermis on Verhoeff-Van Gieson stain, but no clear diagnosis could be made. A second skin biopsy was performed which showed diminution of collagen fibres in reticular dermis and areas in papillary dermis lacking elastic fibres. Differential diagnoses were revised to include pseudoxanthoma-like papillary dermal elastolysis, but histopathology results were not definitive for the diagnosis. The diagnosis of pseudoxanthoma-like papillary dermal elastolysis was made based on the morphology and location of the lesions, epidemiological factors, and histopathological findings. No treatment was initiated, but the patient was content with knowing the diagnosis and agreed to vigilant monitoring of the lesions. This case discourages the sole reliance on histopathological evidence and reminds the importance of gathering clinical evidence to support the diagnosis of pseudoxanthoma-like papillary dermal elastolysis.
Atypical bullous pemphigoid after linagliptin intake (Preprint)
Authors: Salloum Antoine , Bazzi Nagham , Habre Maya
Published: June 2020

UNSTRUCTURED

Bullous pemphigoid is among the commonest pruritic skin lesion and affecting mainly the elderly. It is caused by an immunologic reaction between auto-antibodies and hemidesmosome proteins. Several forms of typical bullous pemphigoid post linaglipltin have been reported. However, this is the first reported case of atypical non-bullous pemphigoid after linagliptin intake. The patient presented with multiple erythematous papule and nodules on the upper extremity and on trunk. Diagnosis was made with biopsy followed by direct immunofluorescence. Direct immunofluorescence showed linear IgG and C3 antibodies to hemidesmosomes at lamina Lucida of the basement membrane.
Reseña del libro Why Learn History (When It’s Already on Your Phone)
Authors: Gallo Óscar
Published: June 2020

No precisa de un resumen.
Retos epistemológicos del Trabajo Social: indicios de alternativas al paradigma moderno de bienestar social
Authors: Guzmán Cáceres Maricela , Carrillo Gómez Karla Patricipa , Vázquez Sánchez Idalia
Published: June 2020

En el marco de la sociedad postindustrial y la reconfiguración del Estado de Bienestar, el Trabajo Social como disciplina y práctica científica encara los retos de mediatizar las relaciones entre el Estado, el mercado y la sociedad. Ello amerita repasar los fundamentos epistemológicos de esta disciplina, de ahí que el objetivo principal del artículo sea reflexionar respecto a sus especificidades en el marco del paradigma interdisciplinario y la división sociotécnica del trabajo. Se siguió un método sintético bajo un paradigma constructivista y se emplearon recursos bibliográficos. Se argumenta que la teorización en Trabajo Social es una necesidad ante la búsqueda de asideros existenciales para afrontar la falta de certezas derivada de la crisis de los metarrelatos de la modernidad y las contradicciones internas del Estado de Bienestar. Se concluye que el Trabajo Social como disciplina encuentra una veta potencial en la indagación de epistemologías alternativas al paradigma occidental, en particular aquellas vinculadas al buen vivir, en tanto que complementan la búsqueda de bienestar y calidad de vida ligadas al ejercicio de intervención del trabajo social, en función de su vocación emancipadora.
Evolución y estado actual de la ciencia y la tecnología en República Dominicana
Authors: Riggio-Olivares Giovanna
Published: June 2020

Este artículo ofrece una revisión general del estado actual de la ciencia y la tecnología en la República Dominicana, describiendo la evolución del marco institucional y normativo de este sistema en el nivel nacional, así como las principales políticas públicas, estrategias e instrumentos que se han implementado para la regulación y la promoción de la actividad científica y tecnológica del país. El estudio aporta datos recientes sobre la capacidad, los resultados científicos y el posicionamiento alcanzado por el país en este sector a la luz de algunos indicadores y analiza brevemente el papel que desempeñan las universidades dominicanas en este sistema. Los resultados del análisis realizado indican que, si bien el balance de los indicadores de República Dominicana en la última década es positivo, todavía el país se encuentra lejos de alcanzar el nivel de desarrollo de muchos de los países de América Latina en materia de ciencia y tecnología. Las conclusiones ponen de relieve que la búsqueda de un mejor desempeño del país en este ámbito conlleva la superación de una serie de barreras, señalando debilidades del marco institucional, desarticulación entre los distintos actores del ecosistema nacional de ciencia, tecnología e innovación, escasa capacidad de financiamiento e insuficiente asignación de recursos para la ejecución de proyectos de investigación e innovación y la ausencia de políticas científicas en la mayoría de las universidades dominicanas.
La vorágine: el antiviaje determinista de Arturo Cova
Authors: Paniagua Gutiérrez Edwin Rafael
Published: June 2020

El presente artículo corresponde a un análisis de la novela La vorágine, de José Eustasio Rivera. En primer lugar, se presenta un contexto de la obra (literario e histórico). Luego, se explica que lo narrado por Arturo Cova no es un viaje, sino un antiviaje: un desplazamiento continuo y forzoso. Se aplica un esquema narratológico mínimo para analizar la trayectoria del personaje principal y, posteriormente, se conceptualiza el determinismo evidenciado en el libro, en sus manifestaciones ambiental, sociológica y psicológica, y se identifica su presencia en la novela. Como metodología, se refieren citas y hechos que justifican la tesis de que Arturo Cova es arrastrado por las circunstancias; por lo cual se trata de un desplazamiento determinista. Él, en lugar de actuar, reacciona. Se deja llevar por las circunstancias. El remolino lo arrastra hacia el fondo. Al final de la obra, se puede constatar que tanto la selva como el azar y los otros lo redefinieron, lo reformaron (¿deformaron?), lo reconstruyeron. Ya no hay ideales, ya no hay presente ni futuro: “la selva lo devoró”.
Período de transición del niño y el adolescente a la adultez tratado con Hormona de Crecimiento Recombinante (RHGH). Una realidad
Authors: Carvajal Martínez Francisco , Piz Ramos Yuraimi , Carvajal Aballe Mónica
Published: June 2020

La baja talla por Deficiencia de Hormona de Crecimiento es una de las causas endocrinas más frecuentes. El tratamiento se realiza con hormona de crecimiento recombinante (rhgh) durante un período habitualmente de larga duración. Existe un grupo de pacientes que su tratamiento con hormona de crecimiento no concluye en la adultez y debe ser tratado también en ese periodo de la vida. El tema de las transferencias se planteó por primera vez en Estados Unidos en 1984, como consecuencia del importante aumento de supervivencia durante los años setenta y ochenta de niños con patología crónica y discapacitante. Se entiende por transición a una etapa de cambios físicos y psicológicos que, de forma arbitraria, se extiende desde el final de la pubertad hasta que la maduración adulta se completa. Es preciso reevaluar los pacientes con deficiencia de hormona de crecimiento tras alcanzar la talla adulta y definir el estado de la secreción de GH para valorar la conti el periodo de transición y en la adultez.
Percepciones sobre actitudes y deseo sexual en personas que cohabitan en pareja con más de dos años de relación
Authors: Gutiérrez Valerio Rosaura , Chávez Esponda Dunia , Guzmán Esquea Deseado
Published: June 2020

La sexualidad humana constituye una parte sumamente importante en la vida de las personas, sin embargo, para muchas de ellas se convierte en un tema lleno de mitos y tabúes. Este trabajo tuvo como objetivo explorar la percepción que tenían las parejas con más de dos años de convivencia sobre el deseo y actitudes sexuales como punto de partida para visibilizar las creencias, las conductas aceptadas y rechazadas que pueden estar influenciando en el disfrute o en la disfuncionalidad de una acoplada relación conyugal. Se aplicaron cuestionarios a una muestra de 52 personas del Cantón Puyo, Ecuador. Se incluyeron variables como: edad, sexo, tiempo de relación con la pareja, edad que tenía cuando tuvo su primera relación, si era mujer: situación en su ciclo reproductivo (menstruación, amenorrea, menopaúsica, embarazo) y nivel de estudios. Se utilizaron gráficos de barras, tablas de contingencia y pruebas Chi cuadrado. Los resultados mostraron que, en el campo del deseo, las actitudes sexuales y la fantasía, los hombres manifestaron que les gusta el sexo con mayor frecuencia que las mujeres y que sienten mucho placer o disfrute al pensar en el sexo. En cambio, las mujeres declararon que raramente o algunas veces tienen pensamientos sexuales, observándose una menor motivación por la actividad sexual, ya sea por problemas laborales o financieros, en muchos de los casos encuestados. Estos resultados permitirán reforzar en los talleres realizados, los temas que generaron distanciamientos en las parejas.
Complicaciones del uso de catéter venoso central en pacientes de la Unidad de Cuidados Intensivos en el Hospital General Plaza de la Salud en el período de junio 2017 – junio 2018
Authors: Espiritusanto Lora Darlene , Cabrera Luis Jasmín , Eunice Cid Emilia
Published: June 2020

Introducción: el uso de un catéter venoso central es esencial para el manejo de miles de paciente en los centros hospitalarios en República Dominicana y el resto del mundo. No obstante, los CVC están asociados a varias complicaciones, incluyendo algunas que son potencialmente fatales.

Método: se realizó un estudio observacional descriptivo retrospectivo en el área de UCI en el Hospital General de la Plaza de la Salud, en el cual se evaluaron los historiales clínicos de 93 pacientes a los que se les colocó un CVC en el periodo de junio 2017 - junio 2018.

Conclusión: en este estudio se observó que dentro de una muestra de 93 pacientes a los cuales se les colocó un CVC en el Hospital General de la Plaza de la Salud en el periodo junio 2017- junio 2018, un 19 % presentaron complicaciones por CVC, siendo la infección la complicación más frecuente.