bluuebunny/crossref_metadata_2025 huggingface dataset:
Using an e-Health Intervention to Reduce Prolonged Sitting in UK Office Workers: A Randomised Acceptability and Feasibility Study
Authors: Carter Sophie E. , Draijer Richard , Maxwell Joseph D. , Morris Abigail S. , Pedersen Scott J. , Graves Lee E. F. , Thijssen Dick H. J. , Hopkins Nicola D.
Published: December 2020

Low-cost workplace interventions are required to reduce prolonged sitting in office workers as this may improve employees’ health and well-being. This study aimed to assess the acceptability and feasibility of an e-health intervention to reduce prolonged sitting among sedentary UK-based office workers. Secondary aims were to describe preliminary changes in employee health, mood and work productivity after using an e-health intervention. Healthy, university office workers (n = 14) completed this study. An 8 week randomised crossover design was used, consisting of two trials: Intervention (computer-based prompts) and Control. Eligibility and retention rates were recorded to assess the feasibility of the trial and interviews were conducted following the intervention to explore its acceptability. Sitting, standing and stepping were objectively assessed prior to and during week 8 of each trial. Before and after each trial, measurements of vascular function, cerebrovascular function, mood and work productivity were obtained. This study had eligibility and retention rates of 54.5% and 77.8%, respectively. Participants expressed a lack of autonomy and disruption to their workflow when using the e-health intervention, raising concerns over its acceptability and long-term implementation. Preliminary data indicate that the intervention may improve the patterning of activity accrued during work hours, with increases in the number of standing and stepping bouts completed, in addition to improving vascular function. This e-health intervention is feasible to deliver in a cohort of university office workers. However, adaptations to its implementation, such as personalised settings, are needed to increase acceptability before larger trials can be conducted.
Comparative Analysis of ROS Network Genes in Extremophile Eukaryotes
Authors: Lyall Rafe , Nikoloski Zoran , Gechev Tsanko
Published: December 2020

The reactive oxygen species (ROS) gene network, consisting of both ROS-generating and detoxifying enzymes, adjusts ROS levels in response to various stimuli. We performed a cross-kingdom comparison of ROS gene networks to investigate how they have evolved across all Eukaryotes, including protists, fungi, plants and animals. We included the genomes of 16 extremotolerant Eukaryotes to gain insight into ROS gene evolution in organisms that experience extreme stress conditions. Our analysis focused on ROS genes found in all Eukaryotes (such as catalases, superoxide dismutases, glutathione reductases, peroxidases and glutathione peroxidase/peroxiredoxins) as well as those specific to certain groups, such as ascorbate peroxidases, dehydroascorbate/monodehydroascorbate reductases in plants and other photosynthetic organisms. ROS-producing NADPH oxidases (NOX) were found in most multicellular organisms, although several NOX-like genes were identified in unicellular or filamentous species. However, despite the extreme conditions experienced by extremophile species, we found no evidence for expansion of ROS-related gene families in these species compared to other Eukaryotes. Tardigrades and rotifers do show ROS gene expansions that could be related to their extreme lifestyles, although a high rate of lineage-specific horizontal gene transfer events, coupled with recent tetraploidy in rotifers, could explain this observation. This suggests that the basal Eukaryotic ROS scavenging systems are sufficient to maintain ROS homeostasis even under the most extreme conditions.
TGF-β Pathway in Salivary Gland Fibrosis
Authors: Zhang Xianglan , Yun Jun Seop , Han Dawool , Yook Jong In , Kim Hyun Sil , Cho Eunae Sandra
Published: December 2020

Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland. Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of fibrosis in several organs, including the salivary glands. Among the TGF-β superfamily members, TGF-β1 and 2 are pro-fibrotic ligands, whereas TGF-β3 and some bone morphogenetic proteins (BMPs) are anti-fibrotic ligands. TGF-β1 is thought to be associated with the pro-fibrotic pathogenesis of sialadenitis, post-radiation salivary gland dysfunction, and Sjögren’s syndrome. Potential therapeutic strategies that target multiple levels in the TGF-β pathway are under preclinical and clinical research for fibrosis. Despite the anti-fibrotic effect of BMPs, their in vivo delivery poses a challenge in terms of adequate clinical efficacy. In this article, we will review the relevance of TGF-β signaling in salivary gland fibrosis and advances of potential therapeutic options in the field.
Leptin Mediated Pathways Stabilize Posttraumatic Insulin and Osteocalcin Patterns after Long Bone Fracture and Concomitant Traumatic Brain Injury and Thus Influence Fracture Healing in a Combined Murine Trauma Model
Authors: Garbe Anja , Graef Frank , Appelt Jessika , Schmidt-Bleek Katharina , Jahn Denise , Lünnemann Tim , Tsitsilonis Serafeim , Seemann Ricarda
Published: December 2020

Recent studies on insulin, leptin, osteocalcin (OCN), and bone remodeling have evoked interest in the interdependence of bone formation and energy household. Accordingly, this study attempts to investigate trauma specific hormone changes in a murine trauma model and its influence on fracture healing. Thereunto 120 female wild type (WT) and leptin-deficient mice underwent either long bone fracture (Fx), traumatic brain injury (TBI), combined trauma (Combined), or neither of it and therefore served as controls (C). Blood samples were taken weekly after trauma and analyzed for insulin and OCN concentrations. Here, WT-mice with Fx and, moreover, with combined trauma showed a greater change in posttraumatic insulin and OCN levels than mice with TBI alone. In the case of leptin-deficiency, insulin changes were still increased after bony lesion, but the posttraumatic OCN was no longer trauma specific. Four weeks after trauma, hormone levels recovered to normal/basal line level in both mouse strains. Thus, WT- and leptin-deficient mice show a trauma specific hyperinsulinaemic stress reaction leading to a reduction in OCN synthesis and release. In WT-mice, this causes a disinhibition and acceleration of fracture healing after combined trauma. In leptin-deficiency, posttraumatic OCN changes are no longer specific and fracture healing is impaired regardless of the preceding trauma.
Genome-Wide Association Studies and Transcriptome Changes during Acclimation and Deacclimation in Divergent Brassica napus Varieties
Authors: Horvath David , Zhang Jiaping , Chao Wun , Mandal Ashok , Rahman Mukhlesur , Anderson James
Published: December 2020

Information concerning genes and signals regulating cold acclimation processes in plants is abundant; however, less is known about genes and signals regulating the deacclimation process. A population of primarily winter B. napus varieties was used to conduct a genome-wide association study and to compare the transcriptomes from two winter B. napus varieties showing time-dependent differences in response to cold acclimation and deacclimation treatments. These studies helped to identify loci, candidate genes, and signaling processes impacting deacclimation in B. napus. GWAS identified polymorphisms at five different loci associated with freezing tolerance following deacclimation. Local linkage decay rates near these polymorphisms identified 38 possible candidate genes. Several of these genes have been reported as differentially regulated by cold stress in arabidopsis (Arabidopsis thaliana), including a calcium-binding EF-hand family protein (encoded by BnaCnng10250D) that was also differentially expressed during deacclimation in this study. Thousands of other genes differentially expressed during the acclimation and deacclimation treatments implicated processes involving oxidative stress, photosynthesis, light-regulated diurnal responses, and growth regulation. Generally, responses observed during acclimation were reversed within one week of deacclimation. The primary differences between the two winter B. napus varieties with differential deacclimation responses involved protection from oxidative stress and the ability to maintain photosynthesis.
Special Issue: Molecular Research on Dental Materials and Biomaterials 2018
Authors: Rehman Ihtesham Ur , Melo Mary Anne
Published: December 2020

Worldwide, populations of all ages suffer from oral diseases, disorders, pathological conditions of the oral cavity, and their impact on the human body [...]
Effects of Helioxanthin Derivative-Treated Human Dental Pulp Stem Cells on Fracture Healing
Authors: Yamakawa Daiki , Kawase-Koga Yoko , Fujii Yasuyuki , Kanno Yuki , Sato Marika , Ohba Shinsuke , Kitaura Yoshiaki , Kashiwagi Miki , Chikazu Daichi
Published: December 2020

Bone defects affect patients functionally and psychologically and can decrease quality of life. To resolve these problems, a simple and efficient method of bone regeneration is required. Human dental pulp stem cells (DPSCs) have high proliferative ability and multilineage differentiation potential. In our previous study, we reported a highly efficient method to induce osteogenic differentiation using DPSC sheets treated with a helioxanthin derivative (4-(4-methoxyphenyl)pyrido[40,30:4,5]thieno[2,3-b]pyridine-2-carboxamide (TH)) in a mouse calvarial defect model. However, the localization of the DPSCs after transplantation remains unknown. Therefore, in this study, we investigated the localization of transplanted DPSCs in a mouse fracture model. DPSCs were collected from six healthy patients aged 18–29 years, cultured in normal medium (NM), osteogenic medium (OM), or OM with TH, and fabricated them into cell sheets. To evaluate the efficacy of fracture healing using DPSCs treated with OM+TH, and to clarify the localization of the transplanted DPSC sheets in vivo, we transplanted OM+TH-treated DPSC sheets labeled with PKH26 into mouse tibiae fractures. We demonstrated that transplanted OM+TH-treated DPSCs sheets were localized to the fracture site and facilitated bone formation. These results indicated that transplanted OM+TH-treated DPSCs were localized at fracture sites and directly promoted fracture healing.
Bringing New Methods to the Seed Proteomics Platform: Challenges and Perspectives
Authors: Smolikova Galina , Gorbach Daria , Lukasheva Elena , Mavropolo-Stolyarenko Gregory , Bilova Tatiana , Soboleva Alena , Tsarev Alexander , Romanovskaya Ekaterina , Podolskaya Ekaterina , Zhukov Vladimir , Tikhonovich Igor , Medvedev Sergei , Hoehenwarter Wolfgang , Frolov Andrej
Published: December 2020

For centuries, crop plants have represented the basis of the daily human diet. Among them, cereals and legumes, accumulating oils, proteins, and carbohydrates in their seeds, distinctly dominate modern agriculture, thus play an essential role in food industry and fuel production. Therefore, seeds of crop plants are intensively studied by food chemists, biologists, biochemists, and nutritional physiologists. Accordingly, seed development and germination as well as age- and stress-related alterations in seed vigor, longevity, nutritional value, and safety can be addressed by a broad panel of analytical, biochemical, and physiological methods. Currently, functional genomics is one of the most powerful tools, giving direct access to characteristic metabolic changes accompanying plant development, senescence, and response to biotic or abiotic stress. Among individual post-genomic methodological platforms, proteomics represents one of the most effective ones, giving access to cellular metabolism at the level of proteins. During the recent decades, multiple methodological advances were introduced in different branches of life science, although only some of them were established in seed proteomics so far. Therefore, here we discuss main methodological approaches already employed in seed proteomics, as well as those still waiting for implementation in this field of plant research, with a special emphasis on sample preparation, data acquisition, processing, and post-processing. Thereby, the overall goal of this review is to bring new methodologies emerging in different areas of proteomics research (clinical, food, ecological, microbial, and plant proteomics) to the broad society of seed biologists.
Small but Smart: On the Diverse Role of Small Proteins in the Regulation of Cyanobacterial Metabolism
Authors: Brandenburg Fabian , Klähn Stephan
Published: December 2020

Over the past few decades, bioengineered cyanobacteria have become a major focus of research for the production of energy carriers and high value chemical compounds. Besides improvements in cultivation routines and reactor technology, the integral understanding of the regulation of metabolic fluxes is the key to designing production strains that are able to compete with established industrial processes. In cyanobacteria, many enzymes and metabolic pathways are regulated differently compared to other bacteria. For instance, while glutamine synthetase in proteobacteria is mainly regulated by covalent enzyme modifications, the same enzyme in cyanobacteria is controlled by the interaction with unique small proteins. Other prominent examples, such as the small protein CP12 which controls the Calvin–Benson cycle, indicate that the regulation of enzymes and/or pathways via the attachment of small proteins might be a widespread mechanism in cyanobacteria. Accordingly, this review highlights the diverse role of small proteins in the control of cyanobacterial metabolism, focusing on well-studied examples as well as those most recently described. Moreover, it will discuss their potential to implement metabolic engineering strategies in order to make cyanobacteria more definable for biotechnological applications.
Erratum: Scherzad, A., et al. Molecular Mechanisms of Zinc Oxide Nanoparticle-Induced Genotoxicity Short Running Title: Genotoxicity of ZnO NPs. Materials 2017, 10, 1427
Authors: Scherzad Agmal , Meyer Till , Kleinsasser Norbert , Hackenberg Stephan
Published: December 2020

There is an error in the title [...]
Investigations into Structural Behavior of Concrete-Filled RHS Columns with Unequal Flange Thickness under Compressive Load
Authors: Fu Guangyuan , Fu Gongyi , Li Siping , Yang Jian , Wang Feiliang
Published: December 2020

Previous studies have shown that components with an unequal-walled concrete-filled rectangular hollow section (CFRHS) can achieve a greater resistance under bending than those with equal-walled CFRHS. However, the study on the compressive behavior of the CFRHS column is limited. Therefore, this paper investigates the performance of compressed CFRHS columns with unequal flange thickness, based on experimental and numerical approaches. In the test, the effects of slenderness and eccentricity on the compressive capacity of the CFRHS columns with unequal shell thickness are discussed. Numerical models based on the finite element method are established, to evaluate the resistance and failure pattern of each specimen in the test. Parametric studies are carried out based on the validated model, to investigate the effect of eccentricity, wall thickness, and steel and concrete material properties on the load-bearing capacity of the compressed CFRHS column. In addition, the analytical expressions of the resistance of CFRHS columns with unequal wall thickness are derived, and the prediction values are validated through comparing with the test results. It is found that eccentric compressed columns with unequal-walled CFRHS have a similar load-bearing capacity and better ductility when compared with the equal-walled CFRHS.
Clinical Evaluation of Time Efficiency and Fit Accuracy of Lithium Disilicate Single Crowns between Conventional and Digital Impression
Authors: Park Ji-Su , Lim Young-Jun , Kim Bongju , Kim Myung-Joo , Kwon Ho-Beom
Published: December 2020

The purpose of this study was to demonstrate the time-efficiency and the clinical effectiveness of chairside-fabricated lithium disilicate single crowns by digital impressions compared to the conventional method. Thirteen patients requiring a single crown on the maxillary or mandibular premolar or first molar were assigned as study subjects. The impressions were obtained using the conventional method and two digital methods with intraoral scanners: AEGIS.PO (Digital Dentistry Solution, Seoul, Korea) and CEREC Omnicam (Sirona, Bensheim, Germany). Two types of lithium disilicate single crowns were obtained; a reference crown (by conventional workflow) and a chairside crown (by digital workflow). The total time taken for fabricating the chairside crown was recorded. The replica technique was performed to compare the marginal and internal fit of the two types of crowns. In addition, accuracy of the intraoral scanners was evaluated by the best-fit alignment method. The difference between the groups was analyzed using the two-tailed paired t-test or one-way ANOVA, followed by the Student–Newman–Keuls test for multiple comparisons. Statistical significance was accepted at p < 0.05 for all statistical tests. The time required to obtain the impressions by the AEGIS (7:16 ± 1:50 min:s) and CEREC (7:29 ± 2:03 min:s) intraoral scans was significantly lower than the conventional method (12:41 ± 1:16 min:s; p < 0.001). There was no significant difference between the intraoral scanners. The total working time to fabricate the chairside crown averaged 30:58 ± 4:40 min:s. The average marginal gap was not significantly different between the reference (107.86 ± 42.45 µm) and chairside (115.52 ± 38.22 µm) crowns (p > 0.05), based on results of replica measurement. The average internal gaps were not significantly different. The average value of the root mean square between the AEGIS (31.7 ± 12.3 µm) and CEREC (32.4 ± 9.7 µm) scans was not significantly different (p > 0.05). Intraoral scans required a significantly shorter impression time than the conventional method, and it was possible to fabricate a lithium disilicate crown in a single visit. There were no statistically significant differences in the fit of the restorations and accuracy of the intraoral scanners compared to the conventional workflow.
Occurrence and Characteristics of Extended-Spectrum β-Lactamase-Producing Escherichia coli from Dairy Cattle, Milk, and Farm Environments in Peninsular Malaysia
Authors: Kamaruzzaman Emelia Aini , Abdul Aziz Saleha , Bitrus Asinamai Athliamai , Zakaria Zunita , Hassan Latiffah
Published: December 2020

The emergence and spread of antimicrobial resistance genes and resistant bacteria do not recognize animal, human, or geographic boundaries. Addressing this threat requires a multidisciplinary approach involving human, animal, and environmental health (One Health) sectors. This is because antimicrobial agents used in veterinary medicine have been reported to be the same or similar to those in human medicine use. Extended-spectrum β-lactamase (ESBL) E. coli is a growing public health problem worldwide, and the agri-food industry is increasingly becoming a source of clinically important ESBL bacteria. Accordingly, the aim of this study was to investigate the occurrence and characteristics of ESBL-producing E. coli from dairy cattle, milk, and the farm environment. E. coli isolates were identified by their 16sRNA, and their ESBL production was confirmed using ESBL–CHROMagar media and the double disk diffusion method. Genotypes of ESBL producers were characterized using multiplex polymerase chain reaction (mPCR) assay. It was found that 18 (4.8%) of the total samples were positive for ESBL-producing E. coli. Of these, 66.7% were from milk, and 27.8% and 5.5% were from the farm environment and faecal samples, respectively. Predominant ESBL genotypes identified were a combination of both TEM and CTX-M in eight out of 18 (44.4%) isolates. Four (22.2%) isolates produced the CTX-M gene, two (11.1%) isolates produced the TEM gene, and four (22.2%) remaining isolates produced the ESBL genes other than TEM, SHV, CTX-M, and OXA. The SHV and OXA gene were not detected in all 18 isolates. In all, there were four profiles of genetic similarity. The occurrence of these genotypes in indicator organisms from dairy cattle, milk, and the farm environment further re-enforced the potential of food-animals as sources of ESBL-producing E. coli infection in humans via the food chain. Thus, there is the need for the adoption of a tripartite One Health approach in surveillance and monitoring to control antimicrobial resistance.
Comparative Analysis of Volatile Compounds in Flowers of Different Actinidia Species
Authors: Stasiak Agnieszka , Latocha Piotr
Published: December 2020

Among the actinidia genus (Actinidia spp.) native to China, few species are grown commercially for their edible and healthy fruits. As they are dioecious plants, a lot of interest is paid to effective pollination and to insects as the most efficient pollinators. In this study we have concentrated on the composition of volatile compounds in male flowers of four different actinidia species (A. chinensis var. deliciosa, A. arguta, A. kolomikta and A. polygama) and on the diversity between male and female flower volatiles for the two most winter-hardy species (A. arguta and A. kolomikta) with growing commercial value. Analyses were provided using gas chromatography with mass spectrometry (GC-MS). In total, 120 compounds were found in 15 actinidia genotypes. However, the number of identified compounds varied between species. Different main compounds or groups of volatile compounds characterised flowers of every species. Smaller differences were observed between male and female flowers of the same species. Our results suggest that actinidia flowers could be attractive to pollinating insects.
Polyphenols, Antioxidant Activity and Volatile Compounds in Fermented Leaves of Medicinal Plant Rosebay Willowherb (Chamerion angustifolium (L.) Holub)
Authors: Jariene Elvyra , Lasinskas Marius , Danilcenko Honorata , Vaitkeviciene Nijole , Slepetiene Alvyra , Najman Katarzyna , Hallmann Ewelina
Published: December 2020

At present, the consumption of medical plants and functional foods is growing in the whole world. Rosebay willowherb (Chamerionangustifolium (L.) Holub) is an important medicinal plant that has various pharmacological effects (antioxidant, anti-inflammatory, anticancer, and others), can improve the state of health and well-being, and reduce the risk of various diseases. The aim of this work was to investigate volatile compounds, polyphenols, and antioxidant activity in rosebay willowherb leaves fermented for 24 and 48 h in solid state fermentation under aerobic and anaerobic conditions. High-performance liquid chromatography (HPLC) for polyphenols and the spectrophotometric method for antioxidant activity determinations were used. To recognize and identify the leaves’ fragrances, electronic nose (Alpha M.O.S) measurement technology was used. The results showed that the highest amounts of total polyphenols in dried matter were after 48 h aerobic solid state fermentation (SSF). Antioxidant activity was higher under 48 h SSF compared to the control. The most abundant flavoring compound groups were esters, terpenes, and aldehydes. In unfermented leaves, (z)-3-hexen-1-ol, acetate, hexyl acetate, and trans-hex-2-enyl acetate prevailed, characterized by fragrances of greenery, flowers, and fruits. The undesired esters group compounds, ethyl butyrate and butyl acetate, with pungent odor, were detected after 48 h anaerobic SSF.
Vasorelaxant Effect of Boesenbergia rotunda and Its Active Ingredients on an Isolated Coronary Artery
Authors: Adhikari Deepak , Gong Dal-Seong , Oh Se Hee , Sung Eun Hee , Lee Seung On , Kim Dong-Wook , Oak Min-Ho , Kim Hyun Jung
Published: December 2020

Cardiovascular diseases are a major cause of death in developed countries. The regulation of vascular tone is a major approach to prevent and ameliorate vascular diseases. As part of our ongoing screening for cardioprotective natural compounds, we investigated the vasorelaxant effect of rhizomes from Boesenbergia rotunda (L.) Mansf. [Boesenbergia pandurata (Roxb.) Schltr.] used as a spice and herbal medicine in Asian countries. The methanol extract of B. rotunda rhizomes (BRE) exhibited significant vasorelaxation effects ex vivo at EC50 values of 13.4 ± 6.1 μg/mL and 40.9 ± 7.9 μg/mL, respectively, with and without endothelium in the porcine coronary artery ring. The intrinsic mechanism was evaluated by treating with specific inhibitors or activators that typically affect vascular reactivity. The results suggested that BRE induced relaxation in the coronary artery rings via an endothelium-dependent pathway involving NO-cGMP, and also via an endothelium-independent pathway involving the blockade of Ca2+ channels. Vasorelaxant principles in BRE were identified by subsequent chromatographic methods, which revealed that flavonoids regulate vasorelaxant activity in BRE. One of the flavonoids was a Diels-Alder type adduct, 4-hydroxypanduratin A, which showed the most potent vasorelaxant effect on porcine coronary artery with an EC50 of 17.8 ± 2.5 μM. Our results suggest that rhizomes of B. rotunda might be of interest as herbal medicine against cardiovascular diseases.
Design, Implementation, and Empirical Validation of an IoT Smart Irrigation System for Fog Computing Applications Based on LoRa and LoRaWAN Sensor Nodes
Authors: Froiz-Míguez Iván , Lopez-Iturri Peio , Fraga-Lamas Paula , Celaya-Echarri Mikel , Blanco-Novoa Óscar , Azpilicueta Leyre , Falcone Francisco , Fernández-Caramés Tiago M.
Published: December 2020

Climate change is driving new solutions to manage water more efficiently. Such solutions involve the development of smart irrigation systems where Internet of Things (IoT) nodes are deployed throughout large areas. In addition, in the mentioned areas, wireless communications can be difficult due to the presence of obstacles and metallic objects that block electromagnetic wave propagation totally or partially. This article details the development of a smart irrigation system able to cover large urban areas thanks to the use of Low-Power Wide-Area Network (LPWAN) sensor nodes based on LoRa and LoRaWAN. IoT nodes collect soil temperature/moisture and air temperature data, and control water supply autonomously, either by making use of fog computing gateways or by relying on remote commands sent from a cloud. Since the selection of IoT node and gateway locations is essential to have good connectivity and to reduce energy consumption, this article uses an in-house 3D-ray launching radio-planning tool to determine the best locations in real scenarios. Specifically, this paper provides details on the modeling of a university campus, which includes elements like buildings, roads, green areas, or vehicles. In such a scenario, simulations and empirical measurements were performed for two different testbeds: a LoRaWAN testbed that operates at 868 MHz and a testbed based on LoRa with 433 MHz transceivers. All the measurements agree with the simulation results, showing the impact of shadowing effects and material features (e.g., permittivity, conductivity) in the electromagnetic propagation of near-ground and underground LoRaWAN communications. Higher RF power levels are observed for 433 MHz due to the higher transmitted power level and the lower radio propagation losses, and even in the worst gateway location, the received power level is higher than the sensitivity threshold (−148 dBm). Regarding water consumption, the provided estimations indicate that the proposed smart irrigation system is able to reduce roughly 23% of the amount of used water just by considering weather forecasts. The obtained results provide useful guidelines for future smart irrigation developers and show the radio planning tool accuracy, which allows for optimizing the sensor network topology and the overall performance of the network in terms of coverage, cost, and energy consumption.
Toward Smart Soil Sensing in v4.0 Agriculture: A New Single-Shape Sensor for Capacitive Moisture and Salinity Measurements
Authors: Escriba Christophe , Aviña Bravo Eli Gabriel , Roux Julien , Fourniols Jean-Yves , Contardo Michel , Acco Pascal , Soto-Romero Georges
Published: December 2020

Modern agriculture imposes the need for better knowledge of the soil moisture content to rationalize the amount of water needed to irrigate farmlands. In this context, since current technological solutions do not correspond to the cost or use criteria, this paper presents a design for a new original capacitive bi-functional sensor to measure soil moisture and salinity. In this paper, we outline the design stages from simulation to finished elements of the optimal design to deployment in the fields, considering the mechanical integration constraints necessary for industrialization. The measurement electronics were developed based on the sensor’s electric model to obtain a double measurement. An on-site (field lot) measurement program was then carried out to validate the system’s good performance in real-time. Finally, this performance was matched with that of leading commercially available sensors on the market. This work demonstrates that, after deployment of the sensors, the overall system makes it possible to obtain a precise image of cultivated soil’s hydric condition, with the best response time.
LoRa Architecture for V2X Communication: An Experimental Evaluation with Vehicles on the Move
Authors: Haque Khandaker Foysal , Abdelgawad Ahmed , Yanambaka Venkata Prasanth , Yelamarthi Kumar
Published: December 2020

The industrial development of the last few decades has prompted an increase in the number of vehicles by multiple folds. With the increased number of vehicles on the road, safety has become one of the primary concerns. Inter vehicular communication, specially Vehicle to Everything (V2X) communication can address these pressing issues including autonomous traffic systems and autonomous driving. The reliability and effectiveness of V2X communication greatly depends on communication architecture and the associated wireless technology. Addressing this challenge, a device-to-device (D2D)-based reliable, robust, and energy-efficient V2X communication architecture is proposed with LoRa wireless technology. The proposed system takes a D2D communication approach to reduce the latency by offering direct vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communication, rather than routing the data via the LoRa WAN server. Additionally, the proposed architecture offers modularity and compact design, making it ideal for legacy systems without requiring any additional hardware. Testing and analysis suggest the proposed system can communicate reliably with roadside infrastructures and other vehicles at speeds ranging from 15–50 km per hour (kmph). The data packet consists of 12 bytes of metadata and 28 bytes of payload. At 15 kmph, a vehicle sends one data packet every 25.9 m, and at 50 kmph, it sends the same data packet every 53.34 m with reliable transitions.
Type IIb Heat Labile Enterotoxin B Subunit as a Mucosal Adjuvant to Enhance Protective Immunity against H5N1 Avian Influenza Viruses
Authors: Tang Neos , Lu Chun-Yi , Sue Shih-Che , Chen Ting-Hsuan , Jan Jia-Tsrong , Huang Ming-Hsi , Huang Chung-Hsiung , Chen Chung-Chu , Chiang Bor-Luen , Huang Li-Min , Wu Suh-Chin
Published: December 2020

Human infections with highly pathogenic avian influenza H5N1 viruses persist as a major global health concern. Vaccination remains the primary protective strategy against H5N1 and other novel avian influenza virus infections. We investigated the use of E. coli type IIb heat labile enterotoxin B subunit (LTIIb-B5) as a mucosal adjuvant for intranasal immunizations with recombinant HA proteins against H5N1 avian influenza viruses. Use of LTIIb-B5 adjuvant elicited more potent IgG, IgA, and neutralizing antibody titers in both sera and bronchoalveolar lavage fluids, thus increasing protection against lethal virus challenges. LTIIb-B5 mucosal adjuvanticity was found to trigger stronger Th17 cellular response in spleen lymphocytes and cervical lymph nodes. Studies of anti-IL-17A monoclonal antibody depletion and IL-17A knockout mice also suggest the contribution from Th17 cellular response to anti-H5N1 protective immunity. Our results indicate a link between improved protection against H5N1 live virus challenges and increased Th17 response due to the use of LTIIb-B5 mucosal adjuvant with HA subunit proteins.
Kajian Aspek Interior Kantor (Studi Kasus : Pt. Balai Diklat Perkretaapian)
Authors: Irwansyah Irwansyah , Giovani Giovani
Published: December 2020

Kantor adalah tempat yang digunakan untuk perniagaan atau bisa disebut dengan “Perusahaan” yang dijalankan secara rutin. Kantor terbagi atas dua jenis, yaitu kantor besar atau yang sering disebut kantor pusat dan kantor sederhana atau disebut kantor cabang. Kantor yang  menyenangkan adalah tempat yang tidak membosankan dan dapat membangkitkan gairah kerja. Balai Diklat Perkeretaapian merupakan kantor tempat unit kerja di bawah Badan Pengembangan Sumber Daya Manusia yang bergerak dibidang layanan perkeretaapian. Permasalahan dan penataan pada kantor ini berbeda-beda dimulai dari tata cahaya, kondisi ruangan, serta penataan perabotan yang mempengaruhi ruangan interior tersebut. Secara fisik, interior kantor masa kini lebih dibutuhkan yang bersuasana terbuka dan akrab. Penerapan warna dan cahaya yang tepat dapat menghilangkan sudut-sudut gelap yang ada. Dinding masif dapat dikurangi dengan cara menempatkan kaca transparan di beberapa sisi ruang sehingga kesannya luas dan terbuka. Permasalahan ini dirasa penting untuk dipecahkan dan diberikan solusi dengan membuat sebuah kajian aspek interior kantor. Tujuannya dapat mengoptimalan ruang kerja agar mampu mengembalikan passion karyawan yang bekerja di  dalamnya dan memberikan kesan pertama yang membekas kepada klien.

Kata Kunci : Aspek, Desain Interior, Elemen, dan Kantor
Schwinger Model as Prototype for Confined Fermions
Authors: Almeida Luis , Santos Rodrigo Francisco dos
Published: December 2020

We will present the Schwinger Model by characteristics like Mechanism of Higgs-Schwinger, Fermionic Charge Shielding, and Chiral Anomaly. Confinement and Topological Vacuum are prototype of theories with Confined Fermions. We will present some aspects of Bosonization and, for example, we will make a representation of the Free Field of Dirac with null mass. We will do a review of Schwinger's model with Lowestein-Swieca, and we will discuss the theory. We also will present modified models of Rothe-Stamatescu, Schroer and Thirring, demonstrating its equivalence with Sine-Gordon's theory.
Desain Simulasi Robot Kesetimbangan Dua Roda Dengan Kecerdasan Buatan
Authors: Hartayu Ratna , Santoso Santoso , Kaleka Abraham Octorio Umbu , Musakhol Moh. Khilmi
Published: December 2020

Dalam penelitian dijelaskan salah satu metode alternatif analisa kontrol pada robot kesetimbangan dua roda dengan menggunakan progam simulasi. Program simulasi menggunakan software Matlab. Penelitian ini menghasilkan analisa simulasi kontrol, berupa analisa data sensor  gyroscope, simulasi PID dan logika fuzzy. Pada simulasi PID nilai kestabilan didapat pada Kp=100, Ki=200, Kd=10, hasil analisa data gyroscope didapat nilai minimum pada 0,074616, nilai maksimum 0,110321, dengan nilai rata-rata 0,092469, standar deviasi 0,025247, jumlah data 0,184937. Penerapan logika fuzzy pada deteksi sudut dan pemberian nilai PWM, menghasilkan data kestabilan nilai konstanta PID. Penelitian ini diharapkan menjadi acuan pemberian nilai kontrol pada robot, dan untuk penelitian berikutnya dapat dikembangkan dengan menambahkan filter komplement atau kalman untuk menghasilkan kestabilan gerak robot.
Rancang Bangun Aplikasi Pengaduan Pelanggan Berbasis Web Menggunakan Framework Codeigniter Di Indotechno Purwokerto
Authors: Casro Casro , Purwati Yuli , Setyaningsih Gustin , Kuncoro Adam Prayogo
Published: December 2020

Teknologi yang berkembang sangat cepat berpengaruh besar terhadap kehidupan manusia untuk kemudian dimanfaatkan dalam segala bidang, salah satunya bidang bisnis penyedia barang dan jasa. Indotechno Purwokerto merupakan perusahaan yang berfokus pada jasa penyedia kebutuhan hardware, maintenance, networking, multimedia dan security system. Proses pendataan aduan pelanggan di Indotechno Purwokerto masih menggunakan media kertas dan diolah menggunakan software Microsoft excel yang disimpan di komputer karyawan customer service, selain itu komputer karyawan yang bertugas melayani pengaduan sesuai dengan job descriptionription masing-masing belum saling terhubung satu sama lain. Selain itu pelanggan perusahaan Indotechno harus menghubungi secara langsung melalui call center atau dengan cara mendatangi kantor perusahaan Indotechno untuk menyampaikan keluhannya. Cara ini memiliki keterbatasan dikarenakan pengaduan hanya akan dilayani pada jam dan hari operasional perusahaan saja. Penelitian ini bertujuan untuk merancang dan membangun sebuah aplikasi pengaduan pelanggan berbasis web menggunakan framework codeigniter di perusahaan Indotechno Purwokerto. Pengumpulan data penelitian dilakukan dengan cara observasi, wawancara dan studi literatur. Metode pengembangan sistem menggunakan waterfall. Hasil penelitian ini adalah sebuah aplikasi pengaduan pelanggan berbasis website yang diharapkan dapat memberikan solusi agar pelayanan dan pengolahan data keluhan pelanggan dapat lebih cepat ditangani. Hasil pengujian blackbox menunjukkan bahwa semua fitur dalam aplikasi dapat berjalan sesuai harapan.
Pengembangan Sistem Informasi Manajemen Praktik Kerja Lapangan Penerapan Semua Program Studi Politeknik Negeri Tanah Laut
Authors: Amirudin Muhammad Muslih , Herpendi Herpendi , Julianto Veri , Sholeha Eka Wahyu
Published: December 2020

Program Praktik Kerja Lapangan (PKL) diterapkan pada Politeknik Negeri Tanah Laut yang sebelumnya telah dibangun sistem pengelolaan proses kegiatan PKL yaitu Sistem Informasi Manajemen Praktik Kerja Lapangan (SIMPKL), dapat di akses pada laman https://simpkl.politala.ac.id. Hasil observasi penulis yang dilaksanakan pada saat menggunakan sistem tersebut, terdapat beberapa kekurangan yang ada pada SIMPKL. Adapun kekurangannya yaitu belum dilakukannya dinamisasi sistem berupa persentase penilaian akhir, batas waktu seminar, batas waktu pendaftaran seminar, batas waktu revisi, batas waktu pemberkasan, perbaikan tampilan modal pada jadwal seminar, muat ulang halaman secara otomatis setelah penginputan jadwal seminar, menu mahasiswa belum lulus PKL, menu mahasiswa selesai PKL, serta penambahan fitur user yaitu peserta seminar tidak perlu membawa kertas form melihat seminar, penulis menyarankan untuk langsung login pada sistem, yang diverifikasi oleh pembimbing. Kemudian perlu diterapkannya pada semua program studi yang ada di Politeknik Negeri Tanah Laut, karena saat ini masih diterapkan dalam program studi teknologi informasi. Solusi dari permasalahan yang telah dipaparkan penulis membangun Pengembangan Sistem Informasi Manajemen Praktik Kerja Lapagan untuk Penerapan Semua Program Studi pada Politeknik Negeri Tanah Laut dibangun menggunakan bahasa pemrograman Hypertext Markup Language (HTML), framework Codeigniter (CI) dan Hypertext Preprocesor (PHP), metode perancangan menggunakan Unified Modelling Language (UML) yang dirancang menggunakan Microsoft Visio, perancangan user interface menggunakan Cascading Style Sheet (CSS), JavaScript dan Balsamiq Mockup 3 sedangkan basis data yang digunakan adalah MySQLi.
Reseñas
Authors: Martocci Federico , Della Bianca Mariana , De Juan-García José María , Alvarez Carlos Alberto , Martínez Martínez Juan Miguel
Published: December 2020

Ferreyra, S. (2018).El peronismo denunciado. Antiperonismo, corrupción y comisiones investigadoras durante el golpe de 1955. Eudem-Grupo Editor Universitario: Mar del Plata, 118 páginas Astarita, C. (2019), Revolución en el burgo. Movimientos comunales en la Edad Media. España y Europa.  Akal: Madrid, 1.148 páginas.   García Hurtado, M. R. (2020) Las innovaciones de la Armada en la España del siglo de Jorge Juan. Consejo Superior de Investigaciones Científicas: Madrid, 618 páginas. Glasman, L. y Rot, G. (Comp.), (2020). Entre la Revolución y la Tragedia. Fotografías, documentos y miradas sobre la Semana Trágica. Buenos Aires: El Topo Blindado, 380 páginas. Babiano, J., Gómez, G., Míguez, A., y Tébar, J. (2018). Verdugos impunes: el franquismo y la violación sistémica de los derechos humanos. Pasado & Presente: Barcelona, 285 páginas.
Artikel
Authors: Ardiyanti Silva , Munastiwi Erni
Published: December 2020

Social media is a tool that makes it easy for users to carry out various activities anytime, anywhere and with anyone without any time limit. Research This aims to describe the role of parents in utilizing social media for children during social distancing, a descriptive analytical qualitative approach is the approach and method used in this research Data collection uses observation, interview and documentation techniques, while the data collection tool is an interview guide.  consists of 10 parents who have children aged 6-13 years and use social media Test the validity of the data through tringulation of data sources The results showed that the role of parents in utilizing social media for children during social distancing in terms of learning and developing creativity of young people  well done,  because parents have their own activities, especially the impact of Covid-19 makes their economic conditions difficult, while the cost of living increases, especially the purchase of internet quota in supporting the online learning process of children during social distancing.
El software, un bien intangible con naturaleza propia
Authors: Troncoso Estrada Olga Lucía
Published: December 2020

Con la invención de la computadora y el internet a mediados del siglo xx, fue necesario enfrentar las dificultades que podían presentarse para la protección de la propiedad intelectual en este nuevo escenario, que lejos de quedar resueltas se vuelven más complejas en la medida que los avances tecnológicos ofrecen nuevos retos. Surgen, así mismo, nuevos bienes inmateriales, como lo es el software, el que jurídicamente se ha asimilado a una obra literaria y en consecuencia se protege por las normas autorales que, no obstante, ha generado múltiples discusiones doctrinales, sosteniéndose por cierto sector que este bien es susceptible de ser patentado en caso de que se reúnan los presupuestos para este tipo de reconocimiento. Otros, defienden la necesidad de una normativa especial que contemple las condiciones especiales de este bien y, ante todo, se vislumbra la necesidad de un organismo especial, dotado de los recursos técnicos necesarios, que se encargue del registro y verificación de los requisitos para su protección, dado que se trata de un bien intangible con unas características particulares que demanda un tratamiento especial.
PAPR reduction using selective mapping scheme in universal filtered multicarrier waveform
Authors: ŞİMŞİR Şakir , TAŞPINAR Necmi
Published: December 2020

In this paper, the selective mapping (SLM) technique possessing the powerful and distortionless peak to average power ratio (PAPR) reduction capability was employed in universal filtered multicarrier (UFMC) waveform that is considered as one of the most promising fifth generation (5G) waveform candidates in order to provide a solution to the PAPR issue encountered in the related waveform. Owing to our SLM-based PAPR reduction implementation performed by employing the SLM scheme between the quadrate amplitude modulation (QAM) mapping and bandwidth-subdivision operations at the transmitter side, successful PAPR reduction results were achieved in a straightforward and effective manner. In the simulations, the effect of the related way of SLM application on alleviating the PAPR and spectral leakages of the UFMC signal amplified via the solid state power amplifier (SSPA) was investigated for various number of phase factor combinations. Besides, the impact of SLM on the bit error rate (BER) of the UFMC waveform was analyzed for varied values of SSPA parameters called smoothness (p) and input back off (IBO) controlling the linearity and operation point of the SSPA, respectively.
自动化监控系统在中卫市南山台扬水泵站更新改造工程中的应用
Authors: 黄 秀芳
Published: December 2020

论文将以中卫市南山台扬水泵站综合自动化工程为例，明确扬水泵站更新改造工程自动化监控系统设计需求，完成包括网络及通信系统、计算机监控系统、微机保护系统、视频监视系统、软件系统等子系统的水泵站更新改造工程自动化监测系统设计，以期能够提高中卫市南山台扬水泵站自动化监测效果的同时，为其他同类工程提供理论参考。
港口码头工程施工技术分析
Authors: 张 伟杰
Published: December 2020

论文分析了港口码头工程的特点，并结合具体的工程案例，讨论了港口码头工程施工技术，并提出了一系列质量控制措施，并为相关研究人员提供一定的借鉴和帮助。
建筑机电安装工程的施工管理分析
Authors: 何 金龙 , 杨 丹
Published: December 2020

机电工程的发展日新月异，机电一体化的应用也越来广泛，在机电安装工程中要注意的地方值得研究探讨。论文就建筑机安装工程中施工管理和施工工艺进行研究，对于出现的问题进行了简要的分析。
加强施工管理提高建筑质量
Authors: 岳 雨勤
Published: December 2020

在建筑工程中，整个建筑的根本就是整体的施工质量，对人们的人身财产安全有着直接影响。因此，加强建筑工程质量的管理，是建筑行业中最为基础的部分，可以有效扩大建筑行业在市场中的占有率，也可以使企业信誉得到根本的提升。
The Model-less Neuromimetic Chip and its Normalization of Neuroscience and Artificial Intelligence
Authors: Hales Colin
Published: December 2020

The conceptual basis of a novel neuromimetic chip
is described. Based on an existing computational bioelectrodynamics study and
adaptive brain signaling biophysics knowledge from neuroscience, the chip is,
in effect, a form of inorganic artificial brain tissue. This ‘physics
replication’ approach involves no abstract models of brain tissue physics or
function. Instead of the physics of a general-purpose computer or the physics
of abstract models of the brain on the chip (analogue or digital), this
neuromimetic chip has an inorganic version of natural adaptive brain signaling
physics. As a result of using the native brain physics, the chip has functionally
relevant endogenous quasistatic electric and magnetic field systems of the form
known to be expressed by excitable cell tissue. Fully developed at macroscopic
scales it can be expected to produce an EEG/MEG-like electromagnetic signature.
This article does an extended analysis to understand an observed generalized lack
of the physics-replication approach and its implications for the neuroscience
of natural and artificial intelligence. This is achieved through a technical
comparison with the neuromimetic chip’s closest relative, the neuromorphic chip
(of the class of general-purpose computers). The results indicate that the
physics-replication approach is a possible but neglected option. It also
reveals that the neuromimetic chip contributes empirical science, in contrast
to the theoretical science conducted using general-purpose computers. Because
of the chip’s novelty and proximity to foundational issues, the article
contributes necessary background information in anticipation of the arrival of
the first prototyping results over the coming years.