bluuebunny/crossref_metadata_2025 huggingface dataset:
In Situ Compensation Method for Precise Integral SQUID Magnetometry of Miniscule Biological, Chemical, and Pow-der Specimens Requiring the Use of Capsules
Authors: Gas Katarzyna , Sawicki Maciej
Published: January 2022

Steadily growing interest in magnetic characterization of organic compounds for therapeutic purposes or of other irregularly shaped specimens calls for refinements of experimental methodology to satisfy experimental challenges. Encapsulation in capsules remains the method of choice, but its applicability in precise magnetometry is limited. This is particularly true for minute specimens in the single milligram range as they are outweighed by the capsules and are subject to large alignment errors. We present here a completely new experimental methodology that permits 30-fold in situ reduction of the signal of capsules by substantially restoring the symmetry of the sample holder that is otherwise broken by the presence of the capsule. In practical terms it means that the standard 30 mg capsule is seen by the magnetometer as approximately a 1 mg object, effectively opening the window for precise magnetometry of single milligram specimens. The method is shown to work down to 1.8 K and in the whole range of the magnetic fields. The method is demonstrated and validated using the reciprocal space option of MPMS-SQUID magnetometers; however, it can be easily incorporated in any magnetometer that can accommodate straw sample holders (i.e., the VSM-SQUID). Importantly, the improved sensitivity is accomplished relying only on the standard accessories and data reduction method provided by the SQUID manufacturer, eliminating the need for elaborate raw data manipulations.
Abiotic Reactivity of De Novo Designed Artificial Copper Peptides (ArCuPs): The Case of C-H Activation
Authors: Prakash Divyansh , Mitra Suchitra , Murphy Morgan , Chakraborty Saumen
Published: January 2022

We report a series of de novo designed Artificial Cu Peptides (ArCuPs) that oxidize and peroxygenate C-H bonds of model abiotic substrates via electrochemically generated Cu-oxygen species using H2O2 as the terminal oxidant, akin to native Cu enzymes. Detailed assessment of kinetic parameters established the catalytic nature of the ArCuPs. Selective alteration of outer sphere steric at the d layers above and below the Cu site allows facilitated access of substrates, where a more pronounced effect on catalysis is observed when space is created at the d layer below the Cu site via Ile to Ala mutation producing a kcat of 6.2 s-1, TONmax of 14800 and catalytic proficiency (kcat/KM/kuncat) of 340 M-1 for the oxidation of benzyl alcohol. Independent spectroscopic studied revealed that the rate of formation of the Cu-oxygen species and the spectroscopic feature of the most active variant is distinct compared to the other ArCuPs. Systematic alteration of outer sphere hydrophobicity led to a correlated tuning of the T2 Cu site redox potentials by ~80 mV. The enhanced activity of the ArCuP variant is attributed to a combination of steric effect that allows easy access of substrates, the nature of Cu-oxygen species, and stability of this construct compared to others, where Ile to Ala mutation unexpectedly leads to a higher thermostability which is further augmented by Cu binding.
Photochemical Degradation of Short-Chain Chlorinated Paraffins in Aqueous Solution by Hydrated Electrons and Hydroxyl Radicals
Authors: DiMento Brian , Tusei Cristina , Aeppli Christoph
Published: January 2022

Short-chain chlorinated paraffins (SCCPs) are a complex mixture of polychlorinated alkanes (C10-C13, chlorine content 40-70%), and have been categorized as persistent organic pollutants. However, there are knowledge gaps about their environmental degradation, particularly the effectiveness and mechanism of photochemical degradation in surface waters. Photochemically-produced hydrated electrons (e-(aq)) have been shown to degrade highly chlorinated compounds in environmentally-relevant conditions more effectively than hydroxyl radicals (·OH), which can degrade a wide range of organic pollutants. This study aimed to evaluate the potential for e-(aq) and ·OH to degrade SCCPs. To this end, the degradation of SCCP model compounds was investigated under laboratory conditions that photochemically produced e-(aq) or ·OH. Resulting SCCP degradation rate constants for e-(aq) were on the same order of magnitude as well-known chlorinated pesticides. Experiments in the presence of ·OH yielded similar or higher second-order rate constants. Trends in e-(aq) and ·OH SCCP model compounds degradation rate constants of the investigated SCCPs were consistent with that of other chlorinated compounds, with higher chlorine content producing in higher rate constants for e-(aq) and lower for ·OH. Above a chlorine:carbon ratio of approximately 0.6, the e-(aq) second-order rate constants were higher than rate constants for ·OH reactions. Results of this study furthermore suggest that SCCPs are likely susceptible to photochemical degradation in sunlit surface waters, facilitated by dissolved organic matter that can produce e-(aq) and ·OH when irradiated.
Titulización : nueva alternativa de inversión y financiamiento en el Perú
Authors: Arroyo Gordillo Pedro Antonio
Published: January 2022

El nuevo instrumento financiero, que ha visto la luz con la puesta en vigencia de la nueva Ley del Mercado de Valores, es la titulización de activos. Este proceso implica la transformación de activos en títulos valores que serán colocados en los mercados capitales.
STATUS OF FISH HATCHERY AND NURSERY MANAGEMENT IN, DHANUSHA, NEPAL
Authors: Chaudhary Priti , Kumar Yadav Pankaj , Kumar Jha Dilip
Published: January 2022

The study was conducted to overview status of fish hatchery and nursery management. The main occupation of owners is hatchery business and 23% owners run as side business. 23% of respondents reared fifteen species including major seven species Rupchand, Puntius, Basai, Bhagi, Bata, Magur and Black carp. 30.8% respondents use brood stock from other hatchery of different place for cross breeding to reduce stress, inbreeding depression and to increase disease resistance, growth, performance and production. 61.53% respondents do not monitor the pond to check water quality pararameters like DO, pH and turbidity of water. The average hatchlings, fish fry and fingerling survivality was found 31.10%, 57% and 64% respectively. The problem encountered were flood, predator, unavailability of feed, hormone, fertilizer, skilled manpower and water shortage. The B/C ratio in private hatchery was 1.59 and 1.31 in government hatchery. Most of the respondents use motorcycle (53.8%) as means of transportation of fish seed. The main severe disease was learnaea followed by argulus. The inputs used in nursery management were less than that of recommended dose. High stocking density of fingerlings found (546.15kg/kattha). 69.23% of respondents sold fish, fry and fingerlings to distant market and 30.8% of fish farmers sold their fish seed products in local market. About 75%, 20% and 5% of hatchery fish seed production transferred through channel 1, channel 2 and channel 3 respectively. The problems faced in market were trader monopoly followed by open boarder, road inaccessibility, transportation loss and lack of market information
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
Authors: Varona Jose F , Landete Pedro , Lopez-Martin Jose A , Estrada Vicente , Paredes Roger , Guisado-Vasco Pablo , Fernandez de Orueta Lucia , Torralba Miguel , Fortun Jesus , Vates Roberto , Barberan Jose , Clotet Bonaventura , Ancochea Julio , Carnevali Daniel , Cabello Noemi , Porras Lourdes , Gijon Paloma , Monereo Alfonso , Abad Daniel , Zuñiga Sonia , Sola Isabel , Rodon Jordi , Vergara-Alert Julia , Izquierdo-Useros Nuria , Fudio Salvador , Pontes Maria Jose , de Rivas Beatriz , Giron de Velasco Patricia , Nieto Antonio , Gomez Javier , Aviles Pablo , Lubomirov Rubin , Belgrano Alvaro , Sopesen Belen , White Kris M , Rosales Romel , Yildiz Soner , Reuschl Ann-Kathrin , Thorne Lucy G , Jolly Clare , Towers Greg J , Zuliani-Alvarez Lorena , Bouhaddou Mehdi , Obernier Kirsten , McGovern Briana L , Rodriguez M Luis , Enjuanes Luis , Fernandez-Sousa Jose M , Krogan Nevan J , Jimeno Jose M , Garcia-Sastre Adolfo
Published: January 2022

Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that plitidepsin distributes preferentially to lung over plasma, with similar potency against across several SARS-CoV-2 variants in preclinical studies. Simultaneously, in this randomized, parallel, open-label, proof-of-concept study (NCT04382066) conducted in 10 Spanish hospitals between May and November 2020, 46 adult hospitalized patients with confirmed SARS-CoV-2 infection received either 1.5 mg (n = 15), 2.0 mg (n = 16), or 2.5 mg (n = 15) plitidepsin once daily for 3 d. The primary objective was safety; viral load kinetics, mortality, need for increased respiratory support, and dose selection were secondary end points. One patient withdrew consent before starting procedures; 45 initiated treatment; one withdrew because of hypersensitivity. Two Grade 3 treatment-related adverse events were observed (hypersensitivity and diarrhea). Treatment-related adverse events affecting more than 5% of patients were nausea (42.2%), vomiting (15.6%), and diarrhea (6.7%). Mean viral load reductions from baseline were 1.35, 2.35, 3.25, and 3.85 log10 at days 4, 7, 15, and 31. Nonmechanical invasive ventilation was required in 8 of 44 evaluable patients (16.0%); six patients required intensive care support (13.6%), and three patients (6.7%) died (COVID-19-related). Plitidepsin has a favorable safety profile in patients with COVID-19.
The Predictive Diagnosis Based on Hurst Indicator and Logistics Trends
Authors: Shpicer V. Ya. , Krivin V. V. , Tolstov V. A.
Published: January 2022

The article presents the results of identifying pre-failure conditions. The results based on fractal analysis and nonparametric statistics. The NPP equipment units are highly reliable systems for long life cycle. These systems are characterized by slow graduating failures. This happens due to the accumulation of irreversible damage. Standard information measuring systems supply time series. They are traditionally processed by parametric methods. The processing of experimental data can be automated for industrial monitoring of NPP equipment parameters.
МОДЕРНІЗАЦІЯ МАГІСТЕРСЬКОЇ ПІДГОТОВКИ МАЙБУТНІХ ПЕДАГОГІВ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ В УМОВАХ ЦИФРОВІЗАЦІЇ ОСВІТНЬОГО ПРОСТОРУ
Authors: Іваницький О. І. , Панічук М. А. , Сичева С. В.
Published: January 2022

У статті досліджено шляхи модернізації професійної підготовки майбутніх педагогів закладів вищої освіти в умовах цифровізації освітнього простору. Емпіричне дослідження показало значну неоднорідність рівнів педагогічних знань та рівня цифрової компетентності здобувачів освітньої програми «Педагогіка вищої школи». Обґрунтовано детермінанти, орієнтація на які сприяє більш ефективній магістерській підготовці майбутніх педагогів закладів вищої освіти. Виділені детермінанти вказують на шляхи модернізації професійної підготовки майбутніх педагогів закладів вищої освіти, а саме: 1) забезпечення гнучкості й варіативності освітньо-професійної програми, силабусів і робочих програм, змісту дисциплін; 2) здійснення планомірних науково-методичних досліджень членами проєктної групи щодо вихідного рівня підготовленості студентів до навчання в магістратурі, ефективності формування загальних і фахових компетентностей майбутніх педагогів закладів вищої освіти; 3) порівняльне вивчення ефективних систем діяльності педагогів закладів вищої освіти, націленість на формування в магістрантів елементів авторської системи діяльності викладача закладу вищої освіти; 4) демонстрацію викладачами активної взаємодії зі студентами як експертів, «тренерів», консультантів, фасилітаторів; 5) урахування рівня підготовленості студента до навчання в магістратурі, розроблення й виконання індивідуальних програм підготовки студентів; 6) фокусування на актуальних рекомендаціях та визнаних ефективних практиках Європейського освітнього простору. На основі виділених детермінантів оновлено освітньо-професійну програму «Педагогіка вищої школи», зокрема, доповнено перелік фахових компетентностей, поданих у Стандарті вищої освіти України. Представлені в освітньо-професійній програмі компетентності інтегрують досягнення педагогіки, освітнього менеджменту, педагогічної психології, акмеології, андрагогіки та публічної діяльності, що підкреслює націленість програми на підготовку нової генерації дієвих та ефективних педагогів закладів вищої освіти, здатних до інноваційної й пошуково-дослідницької діяльності.
КОУЧИНГ ЯК ПРОЦЕС ПІДТРИМКИ ТА РОЗВИТКУ НОВИХ МОДЕЛЕЙ ПОВЕДІНКИ В ОСВІТНЬОМУ СЕРЕДОВИЩІ
Authors: Зонов Б. С.
Published: January 2022

У статті розкрито поняття педагогічного коучингу, що визначають його як різновид технології науково-методичного супроводу, систему андрагогічних принципів і прийомів, які сприяють розвитку потенціалу особистості та групи людей, котрі спільно працюють (команди, організації), а також забезпечують максимальне розкриття і дієву реалізацію цього потенціалу. Зауважується, що коучинг у системі вищої освіти України може бути використаний як універсальний інструмент, котрий дає можливість ефективно працювати на суб’єкт-суб’єктному рівні. Розкривається таке поняття, як коучинг-технологія, що базується на демократичному стилі керівництва, заснованому на системному мисленні та певним чином організованій техніці запитань, що в кінцевому підсумку орієнтована на перспективу позитивних змін й оптимізацію виробничих відносин на основі співробітництва та налагодження зворотного зв’язку. Акцентовано увагу на тому, що коучинг – це сфокусований на рішенні, орієнтований на результат систематичний процес співробітництва, внаслідок якого коуч сприяє покращенню виконання завдань, збільшенню життєвого досвіду, самостійному навчанню й особистісному зростанню людей. У статті автор зауважує, що класичний коучинговий процес можна розглядати через декілька поетапних кроків: аналіз (оцінка рівня компетенцій, узгодження особистих цілей і цілей організації, які реалізуються в процесі коучингу, укладення контракту); планування (визначення ключових чинників успіху, підготовка плану розвитку вмінь, узгодження плану дій і моніторинг ефективності результатів); впровадження (супровід від моменту «зараз» до моменту «бажане майбутнє», безпосередні дії, відповідно до довгострокових і короткострокових цілей, визначення пріоритетів); оцінку (систематичне надання зворотного зв’язку, схвалення набутих умінь, а також мотивування до відповідальності і прийняття нових викликів, створення методів самодисципліни студента без підтримки коуча). Для фахівців-коучів коучинг – це планований двосторонній процес, в якому людина розвиває вміння та досягає окреслених компетенцій за допомогою ретельної оцінки, цілеспрямованої практики та регулярного зворотного зв’язку.
СОВРЕМЕННЫЕ КРАУД-ИНВЕСТИЦИИ: ОСОБЕННОСТИ, ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ
Authors: Арсланов Шамиль
Published: January 2022

Целью исследования является попытка проанализировать современные механизмы крауд - технологий на основе выявления их особенностей, проблем и перспектив. Методология исследования основана на методах анализа и синтеза, а также систематизации, сравнения, экономического и логического анализа. Научной базой исследования выступили публикации как зарубежных так и российских учёных-исследователей в области развития механизмов краудфандинговой деятельности, в ивкжк иных альтернативных механизмов привлечения частных инвестиций. Результаты. Проанализированы различные аспекты инструментария краудфандинговой деятельности в условиях развития рынка привлечения инвестиционно-финансовых ресурсов, исследована специфика краудфандинговой деятельности с выделением краудлендинга и крауд-инвестирования., а также рассмотрена практика реализации краудфандинговых платформ как в мировом экономическом пространстве, так и в национальной экономике. Выводы. Основываясь на проведенном исследовании, можно утверждать, что рынок альтернативных инвестиционно-финансовых ресурсов России показывает значительный рост и развитие, несмотря на все ограничения и последствия пандемии COVID-19. В тоже время очевидно, что необходимо наращивание потенциала краудфандинговых технологий на основе развития совершенствования эффективных условий и механизмов их регулирования. Необходим постоянный анализ и совершенствование законодательных условий, ориентированных на создание достаточно гибких условий регулирования эффективных краудфандинговых механизмов, а также позволяющее укреплять доверие населения к крауд-технологиям.
СОВЕРШЕНСТВОВАНИЕ УПРАВЛЕНИЯ КОМПЛЕКСНОГО РАЗВИТИЯ ОТРАСЛЕЙ ПРОИЗВОДСТВЕННОЙ ИНФРАСТРУКТУРЫ РЕГИОНА
Authors: Гасанов Магомед
Published: January 2022

Цель работы. В статье анализируются экономические аспекты совершенствования управления комплексного развития отраслей производственной инфраструктуры и перспективы системного формирования видов инфраструктуры. При этом целью исследования является определить стратегические приоритеты эволюции подотраслей инфраструктуры с позиции комплексного исследования отрасли. Метод или методология проведения работы. Проведен системный экономический анализ оптимизации процессов развития отраслей инфраструктуры региона в условиях рыночных отношений и современных вызовов. Основой исследования являются фундаментальные научные труды отечественных и зарубежных учёных в области экономики производственной составляющей инфраструктуры. В ходе исследования использованы методы научного познания: системный анализ, сравнение и экономико-статистические методы. Результаты. Научные результаты анализа позволят использовать комплексный подход формирования и оптимизации составляющей экономики инфраструктуры региона. Среди приоритетных направлений предложена разработка правово-законодательной базы, усовершенствовать в соответствии с новыми рыночными и модернизационными условиями эффективный механизм комплексного и сбалансированного прогнозирования. Сформированы приоритетные пути совершенствования комплексного формирования отраслей инфраструктуры в условиях инновационных преобразований. Область применения результатов. Результаты проведенного исследования могут быть применены при формировании эффективной и радикальной системы экономической инфраструктуры СКФО, а также прогнозировании субъектов Российской Федерации. Вместе с тем результаты анализа рекомендованы для разработки и реализации инвестиционных программ функционирования и системного развития дорожно-транспортной инфраструктуры. Кроме того, реализация стратегических приоритетов автора позволят использовать резервы управления в повышении эффективности отраслевых предприятий в условиях преобразования региональной экономики. Выводы. По результатам проведенного исследования сделан вывод, практическое использование авторской концепции будет способствовать: повышению эффективности функционирования предприятий, сбалансированному развитию составляющих производственно-отраслевой инфраструктуры страны и ее регионов в условиях современных вызовов.
BIDADARI DALAM TAFSIR ALQURAN: KOMPARASI PEMIKIRAN IBN ‘ÂSYÛR DAN AMINA WADUD
Authors: Rozin Moh
Published: January 2022

Isu-isu gender dianggap tidak bisa dilepaskan dari pengaruh sistem teologi paling mendasar dalam agama. Dalam kaitan ini tema bidadari penting untuk dikaji, sebab merupakan bagian penting dari konsep eskatologi Islam. Sementara wacana eskatologi Islam, meskipun kerap menciptakan variasi interpretasi dan memancing perdebatan, namun faktanya diskursus tentangnya selama ini berlangsung statis. Ibn ‘Âsyûr  dan Amina Wadud hadir sebagai sosok yang berusaha menghidupkan kembali pembahasan tersebut. Fokus dari kajian ini adalah bagaimana hakikat bidadari menurut Ibn ‘Âsyûr  dan Amina Wadud, dan bagaimana persamaan dan perbedaan pemikiran keduanya. Metode deskriptif-analitis-komparatif digunakan untuk mengkaji pemikiran kedua tokoh tersebut terhadap ayat-ayat yang mengandung pengertian bidadari, yang meliputi term hūrun ‘īn dan azwāj. Ungkapan hūrun ‘īn, menurut Ibn ‘Âsyûr , perlu dipahami sebagai petunjuk eksistensinya, sementara bagi Amina Wadud, ungkapan tersebut perlu dipahami sebagai petunjuk metaforis, oleh sebab ungkapan yang sebenarnya dimaksudkan Alquran tentang konsep pasangan di Surga adalah ungkapan azwāj yang tidak terikat jenis kelamin. Amina Wadud mengalienasi konsep hūrun ‘īn dari konsep azwāj, sementara Ibn ‘Âsyûr  menganggap kedua istilah tersebut sama atau setara. Perbedaan kontras di antara pemikiran kedua tokoh terdapat dalam argumentasi yang mereka gunakan untuk mendukung pendapat masing-masing. Hal ini berangkat dari latar belakang pemikiran dan konstruksi metodologi yang berbeda.
The Impact of the Fourth Industrial Revolution on Ethical Leadership
Authors: Hai Thanh Nguyen , Van Quang Nguyen
Published: January 2022

Objectives: ethical leadership is a widely discussed topic, but so far there are still debates around this topic, even arguing that ethical leadership is just statements of right and wrong or that it is a style “leadership style”. Now, the impact of the fourth industrial revolution will make ethical leadership even more essential to improving leadership performance. Therefore, the aim of the study is to show the advantages and challenges of the fourth industrial revolution, these impacts on ethical leadership, so that the effects are useful to leadership performance. Focus on developing ethical leadership. Methods / Analysis: this study conducts analysis and evaluation from data sources on Science Direct, Web of Science, and Scopus, thereby showing the basic characteristics of leadership, ethics, ethical leadership, fourth industrial revolution, advantages and challenges, discussions on the impact of the fourth industrial revolution on ethical leadership. Findings: The findings of the study indicate that the ethical leadership qualities are quite stable, such as perseverance, service spirit, tolerance, power sharing, fairness, etc. The impact of the fourth technological revolution will make ethical leaders more effective in their roles, making it easier for leaders to overcome challenges, contributing to improving leadership performance. Novelty / Improvement: research shows that ethical leaders will be dedicated leaders, service-minded leaders, impacted by the fourth technological revolution, making leadership even more powerful. Virtue becomes more and more important. Therefore, in order to successfully implement the fourth industrial revolution, it is necessary to pay attention to developing ethical leadership. Doi: 10.28991/HEF-2021-02-03-05 Full Text: PDF
Water Table Effects on the Behaviors of the Reinforced Marine Soil-footing System
Authors: Vali Ramin
Published: January 2022

This study evaluates the effects of a water table on the behaviors of a geogrid reinforced soil-footing system on marine soft soil layers in Qeshm Island, Iran. The main aim of this research is to recommend the optimum specification of the reinforced soil-footing system. A series of geotechnical tests were adopted to measure the properties of the soil profile. The impacts of the water table and the geogrid layer specifications were evaluated by the finite element analysis to investigate the system’s behaviors. Finally, the optimal reinforced soil-footing is suggested. Doi: 10.28991/HEF-2021-02-03-09 Full Text: PDF
Análisis de la producción de biogás en un Relleno Sanitario en Othón P. Blanco, Quintana Roo
Authors: Carrión Manuel , Murrieta Fernando , González José Luis , Ordaz Alberto , Delgado Victor  Hugo
Published: January 2022

La generación de biogás en un relleno sanitario propuesto para el municipio de Othón P. Blanco fue estimada mediante el Modelo Mexicano de Biogás 2.0. El modelo fue aplicado para un periodo de operación del relleno de 10 años y considerando dos velocidades de degradación (muy rápida y muy lenta). Los resultados del modelo fueron promediados y se estimó que el relleno podría generar en promedio 3,863,923 m' de biogás al año. Esta producción de biogás permitiría de acuerdo con una simulación termodinámica con un ciclo Rankine, generar una potencia neta de 760 kW durante el periodo de funcionamiento del relleno. Este biogás generado se puede aprovechar con el uso de microturbinas. confiriendo así ventajas tanto económicas como ambientales al relleno sanitario con producción promedio de 6,485,078 kWh anuales y disminución de emisión de gases de efecto invernadero.
Abandono escolar no contexto da pandemia:
Authors: Machado Sílvio Nei da Silva , Fritsch Rosangela , Pasinato Darciel
Published: January 2022

O presente artigo tem por objetivo compreender o comportamento dos estudantes da Escola Estadual de Ensino Médio Olindo Flores da Silva, localizada no município de São Leopoldo, região metropolitana de Porto Alegre, no estado do Rio Grande do Sul, durante a pandemia do novo coronavírus, no ano de 2020, quando da suspensão das aulas presenciais e adoção do ensino remoto. Para tanto, os dados foram produzidos por meio de um questionário online disponibilizado aos estudantes da escola na plataforma Google Classroom e nos grupos de mensagens instantâneas do aplicativo Whatsapp. Trata-se de um estudo de caso qualitativo, cujas respostas dos estudantes serão ponderadas por meio da análise textual discursiva. Os efeitos da pandemia foram sentidos por todos os setores da sociedade brasileira e a rotina das escolas foi substancialmente afetada. Neste contexto emergencial de implantação do ensino remoto, vislumbra-se um cenário complexo, cujos atores menos favorecidos acabam sendo excluídos do processo. A pandemia é mais uma das forças contrárias que, somadas a outros fatores externos e internos à escola, podem potencializar o abandono escolar, especialmente no Ensino Médio.
The Problem of Economic Availability of Anticoagulants in COVID-19 Outpatient Treatment
Authors:   Tver State Medical University, Tver, Russian Federation, Vinogradova A. D. , Demidova M. A. ,   Tver State Medical University, Tver, Russian Federation
Published: January 2022

An assessment of the economic availability of direct oral anticoagulants for COVID-19 outpatient treatment was carried out. For each anticoagulant, the average cost of the package and treatment course were determined, the coefficients of availability in relation to the average wage and the minimum living wage were calculated. Based on the results of the study, an ABC analysis was carried out. The costs of dabigatran, apixaban and rivaroxaban were found to be in category A (high cost) in relation to the minimum living wage. The most accessible of the investigated anticoagulants is apixaban 5 mg in a package of 60 tablets, the coefficient of availability of this drug in relation to the average wage was 21.7, in relation to the living wage – 66.1. The low availability of anticoagulants for the course treatment of COVID-19 in outpatient settings justifies the need for the formation of drug programs for COVID-19 outpatient with at the expense of the federal budget.
Features of the Subject Composition of Persons Entitled to Compensation for Moral Harm in the Event of Harm to Life in Case of Provision of Medical Care
Authors:   Moscow bar ", Grishin S. M. ,   Intellectual Solutions"
Published: January 2022

The article examines the subject composition of persons entitled to compensation for moral harm in the event of violation of citizens' rights in the event of harm to life in the provision of medical care, based on the norms of international law, current Russian legislation, theoretical materials and judicial practice. The composition of persons entitled to compensation for moral damage is analyzed. Examples from judicial practice are presented.
IMPLEMENTASI PERATURAN DIRJEN PAJAK NOMOR PER-16/PJ/2014 TENTANG TATA CARA PEMBUATAN DAN PELAPORAN FAKTUR PAJAK BERBENTUK ELEKTRONIK DI PT. BALING BALING BAMBU
Authors: Abdurrasitudin  , Sujadi
Published: January 2022

Penelitian dengan judul “Implementasi Peraturan Dirjen Pajak Nomor PER-16/PJ/2014 Tentang Tata Cara Pembuatan dan Pelaporan Faktur Pajak Berbentuk Elektronik di PT. Baling Baling Bambu”. Tujuan penulis melaksanakan Penelitian adalah untuk pengetahuan praktek pembuatan faktur pajak berbentuk elektronik serta pelaporan di PT. Baling Baling Bambu. Dalam pengamatan yang penulis lakukan hasil pengamatan menunjukan bahwa proses atau prosedur perusahaan dalam membuat, pembetulan bahkan pelaporan SPT Masa PPN sudah sesuai dengan Peraturan Dirjen Pajak Nomor PER-16/PJ/2014 Tentang Tata Cara Pembuatan dan Pelaporan Faktur Pajak Berbentuk Elektronik. Degan beberapa bantuan dari konsultan pajak dan inovasi yang dikembangkan secara personal perusahaan seperti menggunakan aplikasi atau program khusus untuk proses penginputan transaksi sampai dengan proses penomeran sehingga sangat membantu staf devisi pajak dalam pemenuhan kewajiban perpajakan perusahan sebagai Pengusaha Kena Pajak sesuai dengan peraturan atau UU Perpajakan di Indonesia.
De “monumento natural” à “antropogeografia”: ideias de natureza na Revista do Patrimônio (1937-1945)
Authors: Vidal Rafael
Published: January 2022

O trabalho tratará das ideias e representações de natureza publicadas por membros de distintos campos científicos e articulados à revista oficial do Serviço do Patrimônio Histórico e Artístico Naciona
Comparative evaluation of effect of legume type on feed intake among dairy cows fed maize (Zea mays) stover treated with groundnut (Arachis hypogea) and soybean (Glycine max) stover
Authors: Chisowa DM  , Mpofu IDT  , Daura MT  , Syampaku EM
Published: January 2022

This study evaluated the use of maize, groundnut and soybean stover in cattle feeding. The study assessed the value of upgrading the quality of crop residues. The study involved evaluation of palatability of maize stover improved using urea (U), chopped groundnut stover (cGS), chopped soybean stover (cSS), mineralized groundnut stover solution (mGS) and mineralized soybean stover solution (mSS). In the feeding trial, twelve (12) crossbred dairy cows in their second parity were used as experimental units. A 22 factorial experiment within a Completely Randomised Design (CRD) was used. Maize stover was chopped before being mixed with urea, chopped legume stover and mineralized legume stover solutions. The effect of supplementation using maize stover upgraded with U, cGS, cSS, mGS and mSS was studied for supplement intake levels. Urea Ensilage Treatment (UET) was used as the novel therapy in the study. Both legume type and processing method had influence on supplement intake of maize stover. Groundnut stover had significantly (p˂0.05) higher (0.99kg/day, se=0.04) effect on supplement intake of maize stover than soybean stover(0.83kg/day, se=0.04). The use of mineralized legume stover solution proved significant (p˂0.05) to the use of chopped legume stover in improving the intake of maize stover. Results have indicated that intake was highest (1.01kg/day, s.e=0.04) for mineralised groundnut stover solution and lowest (0.67kg/day, s.e=0.04) for Urea Ensiling Treatment.
A review on synthesis methods of tricyclic 1,2,3,4-tetrahydrocarbazoles
Authors: Nitin Kumar  , Vinod Kumar  , Yogita Chowdhary
Published: January 2022

In this review article, we discussed old to new synthetic methods used for the preparation of 1,2,3,4-Tetrahydrocarbazole (THCz) based on reported literature. Around the worldwide, various researchers energetically reported new synthetic methods for tetrahydrocarbazoles preparation using conventional method or microwave method or use of catalyst. This review will be helpful to synthetic and medicinal chemist to find selective method for the preparation of 1,2,3,4-Tetrahydrocarbazoles with good percentage yield and less time. This review will also useful to medicinal chemist to design new biologically active tetrahydrocarbazoles based on reported synthetic methods.
Predicting Maternal Attachment: The Role of Emotion Regulation and Resilience during Pregnancy
Authors: ŞAHİN Berkan
Published: January 2022

Purpose: Evidence suggests that maternal attachment (MA) is both a developmental task of pregnancy and an indicator of compliance with pregnancy and associated with prenatal health. Understanding all aspects of attachment will contribute to improving our understanding of developing preventions.

Methods: The study design was prospective cohort study. The relationship between emotion regulation skills or psychological resilience of pregnant women in the second or third trimester period and postpartum MA was investigated. After written consent was obtained, two interviews were completed with the participants. In the first interview, Difficulties in Emotion Regulation Scale-Brief Form (DERS), Connor–Davidson Resilience Scale (CD-RISC) was applied to all participants. In the second interview, the Maternal Attachment Inventory (MAI) was applied to the participants in the 30-40 days postpartum period.

Results: Of the 120 women recruited, 77 completed two interviews. A negative correlation between MAI scores and DERS scores (p=0.001) and a positive correlation between MAI scores and CD-RISC scores (p
Assessment of neck pain, low back pain and disability in patients isolated at home due to mild-COVID-19: a cross-sectional study
Authors: BARĞI Gülşah , ÖZONAY Kübra
Published: January 2022

Purpose: Neck pain (NP), low back pain (LBP) and related disability status in patients with COVID-19 have been not known yet. Therefore, pain and related disability status in patients with mild COVID-19 was investigated in current study.

Methods: Patients with mild-COVID-19 (n=45, 40.64±17.18 yr) were included in current study. Pain perception (Numeric Rating Scale) and disability status (Neck Disability Index (NDI), Oswestry Disability Index (ODI)) were evaluated remotely on the online forms at pre-COVID-19, isolation, and post-COVID-19 periods between 18 February 2021 and 9 May 2021.

Results: NP existed in 9 (20%) patients (resting: 0.96±2.29, activity: 1.02±2.42) at pre-COVID-19, 16 (35.6%) patients (resting: 1.93±3.02, activity: 2.27±3.52) at isolation and 6 (13.3%) patients (resting: 0.62±1.81, activity: 0.87±2.31) at post-COVID-19 periods (p
Penerapan Model Pembelajaran Cooperative Learning Tipe Everyone Is A Teacher Here Pada Pembelajaran Pai Materi Pokok Makanan Yang Lalal Dan Haram Sebagai Upaya Meningkatkan Hasil Belajar Di Kelass 9 F Smp Negeri 4 Gresik
Authors: Ghozi Abdullah Al
Published: January 2022

Penerapan model cooprative learning tipe Everyone Is A Teacher Here pada pelajaran PAI materi pokok yang halal dan haram dalam upaya meningkatkan hasil belajar di Kelas 9 F SMP 4 Gresik dapat di ketahui dengan menggunakan tiga tahap siklus analisis yakni perencanaan, pengamatan dan refleksi. Sehingga mampu menjawab permasalahan tentang Bagaimanakah penerapan model pembelajaran cooperatif learning tipe everyone is a teacher here pada pembelajaran PAI materi pokok makanan yang halal dan haram dapat menngkatkan keaktifan dan hasil belajar. tampak pada hasil penelitian sebelum menggunakan model pembelajaran cooperative learning tipe everyone is a teacher here mencapai rata-rata 74.4. ketuntasan klasikal pada siklus I adalah 72.22 % dan siswa yang tidak tuntas sebanyak 10 siswa. Kemudian pada siklus II rata-rata siswa mencapai 84.38 dan pada siklus III naik menjadi 84.55. Prosentase ketuntasan klasikal naik dari 91.67 % naik menjadi 100 %. penggunaan model pembelajaran cooperatif learning tipe everyone a teacher here, guru dapat meningkatkan peran serta siswa dalam proses pembelajaran / siswa sebagai subyek belajar.
Effect of preliminary laser treatment of 12Cr18Ni10Ti steel surfaces on their diffusion welding
Authors:   LLC “Aviaspace Technologies”, Liushinskii A. V. , Petrovskii V. N. ,   National Research Nuclear University MEPhI, Yolkin V. N. ,   N.A. Dollizhal Research and Design Institute of Power Engineering
Published: January 2022

Specific features of the influence of laser processing applied to surfaces of 12Cr18Ni10Ti stainless steel samples on formation of bonding by the diffusion welding are considered.  The laser fluency was 2.1; 3.2 and 4.3 J/sm2, the diameter of spot was 220 µm. The beam scanning was carried out both in one direction and in two perpendicular directions. As a result of the laser processing with different mode parameters, there on their surfaces are formed microroughnesses of different heights. The researches demonstrated that the size of these microroughnesses is the main factor having an influence on the strength of welded joints. It agrees well with the data of experiments carried out earlier. The preliminary laser treatment of welding surfaces before diffusion welding brings a possibility to lower the temperature of a diffusion bonding process.
Interaction of B and Hf with oxygen in a nickel melt at РAr = 0.1 MPa and analysis of nonmetallic inclusions
Authors:   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences, Burtsev V. T. , Chabina E.B. ,   Russian research institute of aviation materials “VIAM”
Published: January 2022

The deoxidation of complex alloyed nickel-based alloys during melting in vacuum is carried out in the presence of aluminum with strong deoxidizers B and Hf, which requires additional knowledge about the activity of dissolved oxygen. For this, the activity was investigated in model melts Ni – O – (B/Hf, 0.001 – 0.1 wt. % of each) and Ni – O – Al (5 %) – (B/Hf, 0.001 – 0.1 wt. % of each) at 1560 °C and РAr = 0.1 MPa by the method of instantaneous EMF recording using certified sensors. It was shown that a[O] with the introduction of B into the melt without aluminum is 1.3 times less than with the introduction of Hf, and for melts with aluminum, a[O] decreased 1.6 times as compared with Hf. The study of the morphology and composition of non-metallic inclusions of the Ni – O – (B/Hf) systems showed that the inclusions are located along grain boundaries, have various complex configurations and sizes from 2 to 100 μm. These phases contain Ni, Fe, Zr, S, O, as well as Hf, Pb, Bi, Si, Mg after deoxidation of Hf and an increased content of Zr after deoxidation of B.
Applying CO2 and ytterbium fiber lasers to high-performance production of refractory oxide nanopowders
Authors:   Institute of Electrophysics of the Ural Branch of the Russian Academy of Sciences, Osipov V. V. , Platonov V. V. ,   Institute of Electrophysics of the Ural Branch of the Russian Academy of Sciences, Lisenkov V. V. ,   Institute of Electrophysics of the Ural Branch of the Russian Academy of Sciences, Tikhonov E. V. ,   Institute of Electrophysics of the Ural Branch of the Russian Academy of Sciences
Published: January 2022

The main features of obtaining refractory oxide nanopowders using a repetitively-pulsed CO2-laser (10,6 µm) with an average radiation power of 500 W or a CW ytterbium fiber laser (1,07 µm) with a radiation power of up to 700 W are considered. In particular, the influence of pressure, buffer gas composition and average radiation power on the size of nanoparticles and the productivity of their obtaining were studied. Depending on the thermophysical properties of the material, in atmospheric pressure air the productivity of nanopowder synthesis varies from 15 – 23 g/h (YSZ) to 350 g/h (WO3). The mass yield of nanopowder obtained upon evaporation of one target is usually is 30 wt. % of the weight of the initial target. The obtained nanopowders contain weakly agglomerated nanoparticles of spherical shape. The average size of nanoparticles 11 – 20 nm weakly depends on their material. The most important features of using a CW ytterbium laser to obtain nanopowders of refractory oxides are their high transparency for radiation of 1,07 μm, as well as the spraying of many melt droplets. These features led to a reduction in the productivity of nanopowder production and its mass yield. On the other hand, the scattering of laser radiation in porous of the initial target and its concentration in some regions makes it possible to efficiently evaporate oxide targets from materials with a refractive index of more than 1.7 – 1.75. The transition to a repetitively-pulsed mode of radiation (pulse duration 120 μs, square waveform, and peak power 600 W), an increase in the spot diameter and the speed of beam movement over the target surface made it possible to significantly reduce droplet spattering and increase the yield of Nd: Y2O3 nanopowder from 9,7 to 30 wt.% of the weight of the initial target. However, a twofold decrease in the average radiation power led to the fact that the productivity of obtaining the nanopowder was only 15 g/h. Thus, to obtain nanopowders of refractory oxides, it is desirable to use a quasi-CW fiber ytterbium laser, which is specially designed for operation in a repetitively pulsed mode. The obtained nanopowders YSZ, Nd: Y2O3, Al2O3, etc. are used for the manufacture of ceramic solid electrolytes of the YSZ type and highly transparent laser ceramics.
Study of structural and morphological changes during acсelerated oxidative degradation of mixtures of polyoxybutyrate with polycaprolactane
Authors:   V.I. Schumakov National Medical Research Center of Transplantology and Artificial Organs, Vasilets V. N. ,   Branch of N. N. Semenov Federal Research Center of Chemical Physics RAS, Pankina A. P. ,   ANO “ Institute of Biomedical Research and Technologies”, Nemets E. A. ,   V.I. Schumakov National Medical Research Center of Transplantology and Artificial Organs, Belov V. Yu. ,   ANO “ Institute of Biomedical Research and Technologies”, Sevastianov V. I. ,   V.I. Schumakov National Medical Research Center of Transplantology and Artificial Organs,   ANO “ Institute of Biomedical Research and Technologies”
Published: January 2022

Structural and morphological changes in the films of poly(oxybirutyrate-co-oxyvalerate) (P(OB-OV)) with poly-e-caprolactone (PCL) were studied by IR spectroscopy, DSC, and scanning electron microscopy during accelerated oxidative degradation under tests in Fenton reagent. It is shown by the DSC method that the phase separation of the P(OB-OV) and PCL components is observed in the initial mixture. The melting of various phases of P(OB-OV) is observed at temperatures of 147 °C and 157 °C, and PCL melts at a temperature of 61 °C. The degree of crystallinity of P(OB-OV) and PCL in the mixture is 67 % and 50 %, respectively. It was found that the degradation of poly(oxybirutyrate-co-oxyvalerate) prevails during incubation of composite samples in Fenton solution for 2 to 12 weeks. By changing the ratio of the components, it is possible to significantly change the rate of oxidative degradation, the molecular weight and the degree of crystallinity of the polymer composite material P(OB-OV):PCL.
Some features of the analysis of water, soil and ground in mass spectrometers with inductively coupled plasma (ICP-MS)
Authors:   Institute of Physics of the National Academy of Sciences of Azerbaijan, Nurubeyli T. K.
Published: January 2022

The paper discusses the possibilities and limitations of the method of mass spectrometry with inductively coupled plasma on the example of elemental analysis of natural and drinking waters, soils and grounds. It is shown that the combination of this method with the simpler atomic emission method makes it possible to expand the range of determined elements, simplify the mass-spectral analysis and increase its reliability. It is shown that the use of the ICP-MS method in the analysis of various objects makes it possible to determine the majority of elements with extremely low detection limits. The reason for the manifestation of matrix effects is the positive space charge formed between the interface and the extractor, the composition of which is determined by the composition of singly charged argon ions. The increase in the concentration of ions in this region is the appearance of a matrix element, which facilitates the scattering of ions from this region. It was found that the heavier the ions of the matrix element, the more the space charge density increases and the scattering occurs. A serious limitation of the method is associated with interferences due to the presence of a certain amount of two and three-charged ions in the plasma. These ions, which have approximately the same mass as the isotopes of the element being determined, are formed as a result of various plasma-chemical reactions and interfere with the determination.
ВИЗНАЧЕННЯ ГІГІЄНІЧНИХ ВЛАСТИВОСТЕЙ ВКЛАДНИХ ІНДИВІДУАЛЬНИХ ЗАСОБІВ З ВСТАВКАМИ РОСЛИННОЇ СИРОВИНИ У ВЗУТТЯ
Authors: LESHCHYSHYN MARYNA , IUNGIN OLGA
Published: January 2022

Purpose: To conduct experimental studies of embedded hygienic installed insoles with tableted plant inserts in footwearMethodology. The properties of embedded hygienic insoles have been studied for vapor permeability and moisture content according to the methods of GOST 22900-78. The solid inserts were ground and extracted with distilled water for a week to obtain aqueous extracts for microbiological studies. Determination of antimicrobial activity was performed using a culture of S.aureus ATCC 25923 in microtiter 96-well plates in liquid nutrient medium NB spectrophotometrically by optical density (Hipo MPP-96, Biosan, λ = 620 nm, control medium – by the location of a non-sterile sample with (30 × 30 mm) on the surface of sterile NA medium.Findings. To improve the hygienic characteristics of the inner space of the shoe, the research presents embedded hygienic products with solid inserts in the form of tablets from the plant raw materials of medicinal thyme and sage. The technological characteristics of tableted inserts from vegetable raw materials are given. The results of vapor permeability and moisture content in the studied samples are obtained, which correspond to the normative values according to GOST 940-81 and are safe for human feet.Originality. Determination of indicators of vapor permeability and moisture content of embedded hygienic installed insoles with tableted plant inserts and establishing their compliance with regulatory requirements. Determined the regularities of inhibitory effect of aqueous extracts of thyme on the growth of biomass of gram-negative bacteria in planktonic culture.Practical value. Another advantage of custom-made shoes is the ability to consider the customer's preferences regarding shoe care products during the operation. At the same time, an important task is to ensure the hygiene of the inner space of the shoe through the use of insoles containing elements obtained from medicinal plant materials.
Rapid response petrology for the opening eruptive phase of the 2021 Cumbre Vieja eruption, La Palma, Canary Islands
Authors: Pankhurst Matthew J. , Scarrow Jane H. , Barbee Olivia A. , Hickey James , Coldwell Beverley C. , Rollinson Gavyn K. , Rodríguez-Losada José A. , Martín Lorenzo Alba , Rodríguez Fátima , Hernández William , Calvo Fernández David , Hernández Pedro A. , Pérez Nemesio M.
Published: January 2022

How and why magmatic systems reactivate and evolve is a critical question for monitoring and hazard mitigation efforts during initial response and ongoing volcanic crisis management. Here we report the first integrated petrological results and interpretation provided to monitoring authorities during the ongoing eruption of Cumbre Vieja, La Palma, Canary Islands, Spain. The first eruptive products comprised simultaneous Strombolian fountain-fed lava flows and tephra fall from near-continuous eruption plumes. From combined field, petrographic and geochemical analyses conducted in the 10 days following sample collection, we infer low percentage mantle melts with a variably equilibrated multimineralic crystal-cargo and compositional fractionation by winnowing during eruptive processes. Hence ‘rapid response’ petrology can untangle complex magmatic and volcanic processes for this eruption, which combined with further study and methodological improvement can increasingly assist in active decision making.