bluuebunny/crossref_metadata_2025 huggingface dataset:
Poliamit 6/Mika kompozitlerin mekanik ve tribolojik performansına mika katkı oranının etkisi
Authors: Ünal Hüseyin , Yetgin Salih Hakan , Ünal Veysel Furkan
Published: July 2024

Elektrik endüstrisinde çalışan bazı parçalardan elektriksel yalıtkanlık, mekanik performans ve aşınma direnci özellikleri beklenildiği için gerekli performansı sağlayabilecek, ağırlıkça %10, 20 ve 30 oranlarında mika katkılı PA6 (PA6-M) kompozitleri üretilmiştir. PA6-M kompozitleri önce çift vidalı olarak tasarlanan bir kompound makinesinde granül formda üretilmiştir. Sonrasında ise enjeksiyonla kalıplama yöntemi kullanılarak mekanik ve tribolojik test numuneleri basılmıştır. Üretilen kompozit test numunelerinin mekanik ve tribolojik performansları incelenmiştir. Mekanik özelliklerin belirlenmesi için çekme, çentikli izod darbe ve sertlik testleri yapılmıştır. Triboloji deneyleri pim-disk aşınma test cihazında, kuru şartlar altında ve ortam sıcaklığında gerçekleştirilmiştir. Triboloji deneyleri 0,6 m/s hızda ve üç farklı yükte (60N, 120N ve 180N) gerçekleştirilmiştir. Deneyler sonucunda, PA6 polimer ana matrisine mika ilavesi ile üretilen kompozit malzemelerin çekme dayanımı, elastiklik modülü ve sertlikte artış göstermiştir. Buna ilaveten darbe mukavemeti, aşınma oranı ve sürtünme katsayısı değerleri ise azalmıştır. Ayrıca, triboloji deneylerinde çalışılan tüm malzemelerin sürtünme katsayısı ve aşınma oranı değerleri yükün artırılması ile birlikte azalmıştır.
Primary hyperparathyroidism in pregnancy after in vitro fertilization
Authors: Bondarenko A. S. , Bibik E. E. , Voskoboynikov V. V. , Kolegaeva O. I. , Sazonova A. I. , Eremkina A. K. , Lunyakina O. V. , Ionanidze T. Yu. , Aksenenko A. A. , Esayan R. M. , Tetruashvili N. K. , Platonova N. M. , Mokrysheva N. G.
Published: July 2024

Primary hyperparathyroidism (PHPT) in pregnant women is a rare condition, often remaining undiagnosed due to non-specific clinical symptoms. However, it can lead to life-threatening complications for both the mother and fetus. In vitro fertilization (IVF) is also associated with an increased probability of adverse outcomes compared to the general population. Timely diagnostics and personalized treatment, taking into account the extremely high risk of complications if PHPT and pregnancy result from IVF, require attention of healthcare professionals and formation of a multidisciplinary team.
Maternal death in world literature
Authors: Makatsariya N. A.
Published: July 2024

The article highlights issues aimed at maternal death in literature. The literary works of Tolstoy, Turgenev, Bunin, Rabelais, Martin, Pushkin, Mann, etc., are discussed.
Innovative approaches to assessing risk factors, diagnostics and treatment of neonatal thrombosis
Authors: Makatsariya A. D. , Vorobev A. V. , Lazarchuk A. V. , Einullaeva S. E. , Gomenko N. A. , Magomedova F. A. , Bitsadze V. O. , Khizroeva J. Kh. , Makatsariya N. A. , Zubenko V. B. , Tretyakova M. V. , Blinov D. V. , Yagubova F. E. , Gashimova N. R. , Grigoreva K. N. , Ponimanskaya M. A. , Li O. N. , Mostovoi A. V. , Karpova A. L. , Gris J-C. , Elalamy I.
Published: July 2024

Compared to children of other ages, neonates especially seriously ill and premature subjects comprise a high thrombotic risk group. A decline in the incidence of neonatal thrombosis may be accounted for by improved treatment of severe conditions in newborns and increased survival of premature infants. Neonatal and adult hemostasis exhibit distinct physiological features: difference in concentration, synthesis rate of blood coagulation factors, metabolic rate, thrombin and plasmin levels. At the same time, neonatal threshold values for natural blood coagulation inhibitors (protein C, protein S, antithrombin, heparin cofactor II) and vitamin K-dependent coagulation factors (FII, FVII, FIX, FX) are quite low, whereas that of FVIII and von Willebrand factor exceeds those found in adults. Thus, newborns have lower plasma fibrinolytic activity. The main risk factors for developing thrombotic complications are as follows: central venous catheters, altered body fluid volume, liver disease, as well as sepsis and inflammatory processes particularly COVID-19. The significance of congenital and acquired maternal and neonatal thrombophilia may pose an additional risk factor for thrombotic complications. Low-molecular weight heparins are the first-choice drugs in treatment and prevention of neonatal thrombosis.
Psychological Characteristics of Adults Who Have Experienced Sexual Violence in Childhood or Adolescence
Authors: Tukhtaeva D.A. , Lukovtseva Z.V.
Published: July 2024

The relevance of the study is determined by the contradictory ideas about the psychological characteristics of people who experienced sexual violence in childhood or adolescence. The study was exploratory in nature and had no hypothesis. The sample consisted of 40 adults with experience of sexual violence at the specified ages. Interviews, “Traumatic Stress Questionnaire”, “Unfinished Sentences”, "Time Perspective Questionnaire”, “Auto- and Heteroaggression Questionnaire”, “Self-Attitude Research Methodology” were used. The relationships between the values were evaluated according to the scales of the methods (Spearman’s r, p≤0.01). The inconsistency and vulnerability of self-attitude, the severity of depressive and anxious experiences, the psychological alienation of the past, and the negative perception of relationships with parents came to the fore. The emotional-protective role of the mnestic-attentive decrease is determined, the resource features of self-attitude and relationships with others are revealed. The importance of further studies of victims of different gender, age and nosological affiliation, as well as comparing the information obtained with the characteristics of victims who did not seek professional help, is substantiated.
Changes in contractile characteristics of rat skeletal muscles associated with P2-receptor activation after spinal cord transection
Authors: Khairullin Adel E. , Efimova Dina V. , Mukhamedyarov Marat A. , Baltin Maxim E. , Baltina Tatiana V. , Grishin Sergey N. , Ziganshin Airat U.
Published: July 2024

Introduction. Traumatic spinal cord and peripheral-nerve injury is associated with release of proinflammatory cytokines and chemokines, which may stimulate neuronal activity. Adenosine triphosphoric acid (ATP) is an important pain mediator involved in the acute and chronic neuropathic pain development. Its excessive release from primary injured tissue leads to activation of P2-receptors, which may further start secondary injury mechanisms. Although the effects of ATP on the peripheral nervous system are relatively well studied, the pathophysiological role of purinergic signaling after spinalization remains unclear.
The study was aimed at assessing the post-spinalization effects of P2-receptors on the contractile characteristics of rat skeleton muscles.
Materials and methods. The objects of the study were the soleus muscle, the extensor digitorum longus (EDL) muscle, and diaphragm in intact rats and spinalized rats. Seven days after laminectomy followed by spinal cord transection, animals were anesthetized, exsanguinated, and their muscles with nerve stumps were isolated. Contractile response parameters were recorded using mechanomyography (MMG). To study effects of ATP on ligand binding, ATP was added to a bath and mechanical responses in the rat muscles were assessed 7 min after. After washing with Krebs–Henseleit solution, the preparations were incubated with suramin solution for 20 min with subsequent ATP application. Then the mechanical responses in the muscles were again recorded. Statistical significance was assessed using Student's t-test for independent (unpaired) and paired samples.
Results. We found a significant (p 0.05) decrease in the modulating activity of ATP, as the main endogenous signaling agent, in the cholinergic synapse of the soleus muscle from 32.4 to 5.8% and from 13.7 to 5.6% for the EDL muscle after the spinalization (spinal cord injury at the Th6–Th7 level) compared with intact animals. No such dramatic changes were observed in the diaphragm.
Conclusions. Abnormal ATP-mediated modulation of neuromuscular transmission demonstrated in this study supports the involvement of purinergic signaling in the neurotrophic control and functioning of various motor units.
Dysphagia in neurological disorders
Authors: Zaytsevskaya Sofya A. , Lyukmanov Roman K. , Berdnikovich Elena S. , Suponeva Natalya A.
Published: July 2024

Neurogenic dysphagia is a disorder with impaired swallowing, which is caused by various disorders of the central and peripheral nervous systems, neuromuscular transmission, or muscles. Dysphagia is one of the most common and at the same time the most dangerous symptoms of many neurological disorders. Patients with dysphagia often have severe disability, a higher risk of aspiration pneumonia, and significantly increased mortality rate. Despite the availability of many diagnostic screening methods, clinical scales, questionnaires, and instrumental diagnostic methods, the issue of neurogenic dysphagia is underestimated, especially in the early stages. As a result, patients do not receive timely treatment and prevention of dysphagia and associated complications. Validation of available diagnostic scales, development of international protocols and standards for the diagnosis, treatment, and prevention of dysphagia and associated complications are important to establish a unified and evidence-based approach for patients with dysphagia.
A man who changed six spectacles: а case of Heidenhain variant of the Creutzfeldt–Jakob disease
Authors: Thiruvuru Ishwarya , Hazeena Philo , Ramesh Rithvik , Shanmugam Sundar , Avadhani Deepa
Published: July 2024

Creutzfeldt–Jakob Disease (CJD) is a rare and rapidly progressive condition. A 54-year-old professor initially presented with insidious, progressive visual symptoms. Imaging suggested post-infectious encephalitis, but symptoms progressed to ataxia, coordination difficulties, and cognitive decline. Repeat MRI revealed findings consistent with CJD, supported by clinical and electrophysiological evidence. Though 14-3-3 protein in CSF was inconclusive, Heidenhain variant CJD was strongly suspected. Isolated visual symptoms progressing rapidly alongside ataxia and dementia prompt suspicion of this variant. Clinical examination, neuroimaging, and EEG play crucial roles in the diagnosis.
Neuropeptide Y is involved in the regulation of the frequency and strength of rat atrium spontaneous contraction
Authors: Iskakov Nikita G. , Anikina Tatyana A. , Zefirov Andrey L. , Bilalova Gulfiya A. , Zefirov Timur L.
Published: July 2024

BACKGROUND: The relevance of the problem increases due to the established cardioprotective effect of neuropeptide Y in pathological conditions such as hypertension, heart failure, and its possible therapeutic use in cardiovascular diseases.
AIM: Study of the effect of neuropeptide Y on the frequency of spontaneous activity and amplitude-time parameters of the myocardium contraction of the rats’ right atrium during different periods of postnatal ontogenesis.
MATERIAL AND METHODS: The experiments used 73 white outbred rats of 7 days (n=23), 21 days (n=25) and 100 days (n=25) of age. Using the classical strain-gauge method, the parameters of isometric contraction of isolated rat atrial myocardium were determined with the addition of a non-selective Y-receptor agonist. The isometric contraction curve was processed using the Chart 8.0 program. Statistical processing of the results was performed in MS Excel and IBM SPSS Statistics 2020. The significance of the differences was calculated using the Student’s t test. Data were presented as mean ± error of mean (M±m); n was the number of atrial myocardium preparations used. Changes were considered statistically significant at p 0.05.
RESULTS: Neuropeptide Y at a concentration of 10–7 M reduces the frequency of spontaneous activity of the right atrium strips of rats with a preserved sinus node in 7, 21 and 100-day-old animals by 8.1%, 15% (p=0.038) and 7.9% (p=0.046) respectively in comparison with the control value. The amplitude of isometric contraction of the atrial myocardium in 7-day-old animals decreases by 12.4% (p=0.041), the duration of contraction decreases in 21-day-old animals by 12% (p=0.040), and in 100-day-old animals does not change compared to control.
CONCLUSION: Neuropeptide Y reduces the frequency of spontaneous activity, increases the contraction duration, reduces the isometric contraction amplitude of rat myocardial strips in early postnatal ontogenesis.
Use of Unmanned Aerial Vehicles for Combat Purposes: Selected Legal and Medical Aspects
Authors: Konaszczuk Wojciech , Nogalski Adam
Published: July 2024

The COVID-19 pandemic has led to a decrease in human contact and a shift towards cyberspace, resulting in the rapid growth of the IT sector and advancements in engineering using IT solutions. This global phenomenon has also caused the collapse of the world economy and increased tensions. In 2022, the largest armed conflict in European history since World War II occurred due to the actions of the Russian Federation. The article focuses on the alignment of legal regulations at domestic and international levels regarding the use of combat drones. The main thesis confirms the assumption that legal systems of states and organizations are ill-prepared for the use of combat drones. The consequences of using these devices in the medical field are examined to support this thesis. The goal of the article is to present legal solutions that prioritize the protection of life and health. The cognitive value for practice is related to the unification of the conceptual framework and focus on transnational norms that can be used in the fields of both law and medicine. By definition, the article has an international scope due to the problems discussed.
The Legal Basis for Protection against Road Traffic Noise (with Particular Emphasis on the Preparation and Implementation of Road Project and the Stage of Road Operation)
Authors: Poniatowski Piotr
Published: July 2024

The article discusses the regulations under which information on the state of the environment is collected, which can be used at the stage of planning, designing, constructing and operating roads (state environmental monitoring, programmes of environment protection against noise, strategic noise maps). It also addresses the issue of protection against road traffic noise at the stage of road design, construction and alteration, as well as at the stage of road operation. It also identifies environmental protection authorities that play an important role in the context of supervising compliance with noise protection regulations, and briefly discusses the legal remedies available to people exposed to excessive road traffic noise.
The COVID-19 Pandemic in Chile: Challenges of Intergovernmental Relations and Coordination in a Decentralized Unitary State
Authors: Szmulewicz Ramírez Esteban
Published: July 2024

The paper explores the relationship between national and subnational authorities in Chile in the context of the government’s response to the COVID-19 pandemic, particularly analyzing the principle of coordination and the complexities of the state of emergency. The analysis is carried out in light of the constitutional provisions of the Chilean political system. Although subnational authorities developed significant activities to address the effects of the pandemic in their respective territories, particularly the local mayors, this was not accompanied by legal or practical reforms to integrate institutional or procedural changes to incorporate the subnational levels of government in the decision-making processes. During this state of emergency, the formal and informal institutions failed to be accountable for the necessary coordination of their competences at national, regional and local levels. Therefore, the COVID-19 pandemic, occurring during a nationwide constitution-making debate in Chile, opened the opportunity to discuss institutions and arrangements that could lead to an effective and legitimate system of intergovernmental relations in a decentralized unitary state.
The Path of Self-sufficiency among Impoverished Young Adults in South Korea: The Investigation on the Relationship between Psychological Self-sufficiency and Economic Self-sufficiency
Authors: Choi Sangmi , Lee Eui Bhin ,   center for social welfare research yonsei university
Published: July 2024

The purpose of this study is to explore the relationship between emotional independence and economic independence among young adults receiving livelihood support in South Korea. Emotional independence is a concept composed of hope and barriers related to labor and employment, involving a process of increasing hope and overcoming obstacles. This research conceptualizes economic independence as transitioning from livelihood support to regular employment and examines the relationships between employment barriers, employment hope, labor in regular jobs, and the transition from livelihood support using structural equation modeling with a sample of 417 young adults receiving livelihood support. The results indicate that hope serves as a mediator between employment barriers and the transition from livelihood support. The findings highlight the importance of overcoming practical and psychological employment barriers and fostering employment-related hope, including recognizing one's own worth and abilities, being motivated by future prospects, setting goals related to work, and utilizing skills and resources to achieve these goals, for low-income young adults to achieve economic independence through the transition from livelihood support. The study's results extend the understanding of independence by revealing the importance of enhancing emotional capacities in the process of economic independence for low-income young adults. Furthermore, it is expected that these findings will stimulate related research and contribute to the development of a more multidimensional and integrated support system in South Korea's youth-related policies, moving beyond a focus on support for employment, housing, and education to support various aspects of young adults' lives, including entrepreneurship.
The role of Monocyte Chemotactic Protein-3 (MCP3) in pyelonephritis patients in Al- Najaf Governorate, Iraq
Authors: Al-janabi D.R.A. , Aljanaby A.A.J.
Published: July 2024

Pyelonephritis is a serious disease that is widespread in Iraq and is mostly caused by Gram-negative bacteria, which are highly contagious and can spread from an infected person to others. The aim of this article was to evaluate the immunomodulatory role of Monocyte chemotactic protein-3 (MCP3) in the blood serum of patients with acute pyelonephritis and chronic pyelonephritis. A group of patients suspected of having nephritis were sampled in Najaf city, Iraq. Clinical and biochemical tests were performed to confirm their infection. Where 30 patients had acute pyelonephritis and 30 patients had chronic pyelonephritis, in addition to 29 healthy people who were considered control. MPC-3 was measured in the serum of the affected person using ELISA technology. MPC3 levels were significantly elevated (P < 0.05) in the group of patients with pyelonephritis compared with the control group. The chronic pyelonephritis group showed higher levels of MPC-3 in blood serum (P < 0.05) compared to the acute pyelonephritis group. This study showed that MPC-3 is related to pyelonephritis and can be used to help in diagnose the disease.
Features of ophthalmological pathologies that occur against the background of neuropsychiatric disorders
Authors: Parshoeva L.S. , Murtazina R.T. , Siriev K.A. , Asylkhuzina D.S. , Podkopaeva D.P. , Timan A.G. , Abilgasanli A.Y. , Kotykhova A.I. , Neibauer A.S. , Klimenkova M.R.
Published: July 2024

The present study is devoted to a comprehensive analysis of the relationship between neuropsychiatric disorders and ophthalmological pathologies. The paper provides an overview of the latest scientific data on this problem, with an emphasis on the pathophysiological mechanisms linking both groups of diseases. The mechanisms of the influence of psychological factors, such as stress and anxiety, on the state of the visual system, as well as the influence of changes in neurochemistry and neuroplasticity on the development of ophthalmic diseases are considered. The clinical manifestations of ophthalmological pathologies in patients with various neuropsychiatric disorders, including depression, anxiety disorders, schizophrenia, etc., are analyzed in detail. The results of clinical observations and studies confirming the importance of this relationship are presented. In addition, the article highlights modern methods of diagnosis and treatment of ophthalmological manifestations in patients with neuropsychiatric disorders. Psychotherapeutic approaches and rehabilitation methods are considered, taking into account the specifics of the patient’s condition.
Methods and tools for three-dimensional cardiac modeling
Authors: Yarovoy A.V.
Published: July 2024

This article explores the use of methods and tools for three-dimensional modeling of the heart with computer-aided design systems. The use of three-dimensional modeling in medicine is a very pressing scientific and engineering problem. The object of study of this work is the process of three-dimensional cardiac modeling with CAD, and the subject of research is methods and means of three-dimensional modeling of the heart. This publication also provides the key elements required to create a 3D computational model of the heart for biophysical modeling. The article discusses some of the difficulties that arise at various stages of developing 3D cardiac modeling. The approaches which are currently available for three-dimensional computer modeling of the heart are briefly described herein.
Instrumental support for increasing personal resilience against destructive manipulations
Authors: Ognev A.S.
Published: July 2024

The article confirms the possibility of metaphorical description by clients of options for manipulating their behavior that are significant to them. It has been shown that Sandplay Therapy can be used to successfully design and rehearse the desired forms of behavior and form associated sensory standards for subsequent ideomotor training. Evidence is presented of the validity of an assumption that the very elements of such materialized displays of the existing orientation schemes and their photographs support to quickly assess the intensity of the emotional experiences accompanying such modeling and the physiological processes associated with them. It has been established that cardiac measurements followed by calculation of the stress index of the various components of the autonomic nervous system make it possible to assess the level of stress caused by the client’s imagination of a problematic situation for him/her, where he/ she is facing a traumatic manipulation. It is noted that measurements of changes in galvanic skin reactions also allows judging the intensity of experiences that accompany the rebuilding of the associative connection of the depicted items with those manifestations of manipulation of which it is a metaphorical representation. Another assumption has also been confirmed that Sandplay Therapy can be used to effectively prevent some undesired manipulative influences on the client’s personality. At the same time, in addition to establishing the effectiveness of therapeutic procedures, cardiometric measurements and recording of electrodermal activity for the client himself/herself serve as a kind of bio-feedback. Using the latter, the client gets an opportunity to assess how much the response to metaphorical representations of manipulative influences corresponds to how exactly he/she would like to act if they are detected.
How a cardiometer and a polygraph help improve the quality of self-awareness by increasing personal self-efficacy
Authors: Likhacheva E.V. , Ognev A.S.
Published: July 2024

The article shows how exactly it is possible, using a selection of specially prepared visual stimuli, to launch such a mental dialogue by the respondent with his/her internal subpersonalities, denoting complex ideas about his/her desirable and undesirable qualities, which allows him/her to obtain authentic information about his/her Self-concept instrumentally. It is also shown that, according to the data obtained, the process of a person’s awareness of his/her personal characteristics is facilitated by the correlation of his/her ideas about himself/herself in the form of a certain metaphorically described during multimodal game modeling of the Self-concept in the form of answers to questions about what this “my Self” is, with that, which in its complex form he/she classifies as such a complex formation as “not-I”.
Personalized medicine and artificial intelligence in neurology: an individual approach to diagnosis and treatment
Authors: Manin A.F. , Gasparyan M.A. , Gambarova L.R. , Usmanova L.R. , Marshukov I.A. , Bartenev A.D. , Ivashchenko T.V. , Vartanyan V.A. , Baybolatova M.Z. , Agabekova N.N.
Published: July 2024

The article considers an individual approach to the diagnosis and treatment of neurological diseases within the framework of personalized medicine and the use of artificial intelligence capabilities. The main focus is on an individual approach to the diagnosis and treatment of neurological diseases. Modern methods of data analysis and technologies allowing to adapt treatment to a specific patient are considered. Examples of successful applications of machine learning and artificial intelligence algorithms for the prediction, diagnosis and treatment of neurological disorders are also being investigated. The authors also emphasize the importance of collecting and analyzing big data in the development of personalized medicine in neurology and identify prospects for further research and application of this methodology. In addition, the advantages of personalized medicine and the use of artificial intelligence in neurology, such as improving diagnostic accuracy, optimizing treatment and improving the effectiveness of results, were analyzed. The challenges and limitations faced by researchers and doctors when implementing personalized approaches in neurological practice are studied, as well as ethical issues related to the use of patient data and decision-making based on machine learning algorithms are analyzed.
Analysis Prediction of Financial Distress in Islamic Commercial Banks in Southeast Asia Using the Springate S-Score Method
Authors: Septiawan Anisa , Monoarfa Hilda , Cakhyaneu Aneu
Published: July 2024

Financial distress is a condition of financial difficulties before entering the bankruptcy stage, so bankruptcy itself is the impact of financial distress, and the company can no longer be saved. The chaotic economy caused by the COVID-19 pandemic had a negative impact on various sectors, especially Islamic banking institutions, which experienced a decline in financial performance and even experienced financial distress. The purpose of this study is to analyze the prediction of financial distress in Islamic Commercial Banks in Southeast Asia using the Springate S-Score method, as well as to see and determine differences in the level of financial distress in each Islamic Commercial Bank that is used as the research sample. The research method used in this research is quantitative, and the research design used is descriptive and comparative. This study used a purposive sampling technique with a sample of 4 Islamic Commercial Banks in Southeast Asia with a 5 year research period. The data analysis applied descriptive analysis techniques, the Springate S-Score method, and the ANOVA Test. The results of this study indicate that each Islamic commercial bank used as a sample is categorized as distressed based on Springate calculations for the 2017-2021 period, and there are differences in financial distress conditions at each bank.
Defense of the Volga River delta in September–November 1919
Authors: Gnido Sergey V. ,   Saratov State University
Published: July 2024

This article explores a little-studied subject of the civil war in the Astrakhan region. The purpose of the research was to study the combat operations of the 11th Army compounds, which made up the defense of the Volga River delta in the fall of 1919. The Volga River delta defense area, which included the western (Yashkul and Kizlyar directions) and eastern (Dzhambay direction) battle areas, was created on August 24, 1919. In the Dzhambay direction up to the middle of November 1919 the task of active defense of its area was set, which was replaced by the order to eliminate the enemy. In the Kizlyar direction the red troops were assigned the task of stopping the advance of the white troops with their subsequent destruction. In September-November 1919, all the tasks assigned to the command of the Volga River delta defense area were successfully accomplished.
National personnel in state and party authorities in the Lower Volga region (1928–1932): Preparation, retraining and accounting
Authors: Furman Ekaterina L. ,   Volgograd State University
Published: July 2024

The article examines the organization of the process of accounting, training and retraining of national personnel in the Lower Volga region during the period of the first five-year plan, when the success of economic, economic and political campaigns carried out in the country was largely determined by the intensification of efforts in the field of training personnel for the party and state apparatus. As practice shows, the authoritieswere ableto achieve asystematic accounting of personnel inthesystem of Soviet and party bodies only in 1929–1930 – inconditions of regionalization andsystemicmovements, itturned outto be difficultto generate data onthereserve of leading personnel. Aserious problem inthe process of organizing training and retraining of personnel was the low starting level of education of employees (the exception was the German and Ukrainian population of the region). At the same time, the campaign to eliminate illiteracy carried out in the region did not qualitatively change the situation – and at the end of the five-year plan, the percentage of simply literate Soviet and party cadres, often without special education, will remain high.
Altered expression of kisspeptin, dynorphin, and related neuropeptides in polycystic ovary syndrome: A cross-sectional study
Authors: Hestiantoro Andon , Al Maghfira Rachellina Noor , Fathmasari Ratna , Febri Ririn Rahmala , Joyo Ericko Ongko , Muharam Raden , Pratama Gita , Bowolaksono Anom
Published: July 2024

Background: Since kisspeptin (KISS1) in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome (PCOS).
Objective: This study compares the expression levels of KISS1, dynorphin, neurokinin-B, leptin, and neuropeptide-Y in women with and without PCOS.
Materials and Methods: In this cross-sectional study, the peripheral blood samples of 20 women with PCOS and 20 women without PCOS who referred to Yamin Kencana Clinic, Cipto Mangunkusumo hospital, Jakarta, Indonesia were enrolled from August-December 2022. mRNA relative expression of genes related to the central factors associated with PCOS, such as leptin, neuropeptide-Y, KISS1, tachykinin-3, and prodynorphin (PDYN), in PCOS and non-PCOS populations were examined. Gene quantification was carried out by the quantitative polymerase chain reaction method.
Results: The KISS1/PDYN ratio was significantly higher in the PCOS group than in the control group (p = 0.02), and the PDYN was lower in the PCOS group than the control group (p < 0.001). Moreover, the positive correlation between KISS1 and the KISS1/PDYN ratio was significantly stronger in the PCOS group than in the control group (R = 0.93; p < 0.001 vs. R = 0.66, p < 0.001).
Conclusion: Our results suggest that an increased KISS1/PDYN ratio in PCOS women is related to diminished dynorphin expression. Low expression of the gene encoding dynorphin and a high KISS1/PDYN ratio is highly specific to PCOS.
Key words: Dynorphins, Kisspeptins, Neuropeptides, Polycystic ovary syndrome.
Extraocular Muscle Transplantation Surgery for Primary Treatment of Extra Large-angle Squint
Authors: Adio Adedayo , Ezisi Chinyelu , Nkanga Elizabeth
Published: July 2024

Purpose: Large-angle horizontal ocular deviations will commonly require bilateral surgery to correct the primary ocular deviation. However, considering the need for full correction with one surgical procedure and patients’ reluctance to be operated on the good eye, such large horizontal ocular deviations may be managed with true muscle transplantation. The authors present a case series of patients who underwent this procedure and develop a surgical table to guide management.
Methods: Patients with horizontal squints measuring 80 prism diopters (PD) or larger in all age groups who underwent extraocular muscle transplantation surgery between January 2019 and June 2022 in Nigeria were included. Preoperative deviation of the squint, sensory evaluation, surgical dosage, and outcomes were documented. Part of the resected muscle was transplanted to give additional recession in the antagonist muscle. Success was defined as deviation corrected by 60% or more or postoperative ocular alignment within 10 PD or less, six weeks postoperatively.
Results: Fourteen patients with extra-large-angle strabismus were operated. Male/female ratio was 0.6:1. Mean preoperative deviation of 89.6 ± 9.3 collapsed to 6.6 ± 1.8 PD at six weeks and continued to improve to a mean deviation of 2.5 PD at six months postoperatively. When the subgroup of patients who were <18 years were analyzed, the outcome was equally successful; preoperative deviation of 89.4 PD collapsed to 1.4 PD, six months postoperatively. There were equal success rates when those with sensory strabismus were compared with those with binocular vision; preoperative deviation of 92.5 PD in the sensory group and 88.5 PD in the binocular group collapsed to 5.9 PD and 1 PD, respectively, six months after surgery.
Conclusion: A viable alternative for treating extra-large-angle strabismus in adults and children in developing countries was described with good postoperative outcome. In addition, a new expanded surgical dosage table for muscle transplantation surgery corrections of up to 130 PD was developed.
Anatomic and Functional Outcomes of Vitrectomy for Advanced Retinopathy of Prematurity: A Systematic Review
Authors: Casey Anthea , Zahra Raihanny Andrea , Barliana Julie Dewi
Published: July 2024

The success of vitrectomy in the advanced stages of retinopathy of prematurity (ROP) is defined not only by anatomical results, but also by functional outcomes. Studies have indicated that vitrectomy produces better outcomes when performed at an earlier stage (stage 4 vs. stage 5 ROP). This study reviewed the outcomes of vitrectomy in advanced stages of ROP and the associated factors. PubMed, ScienceDirect, Cochrane, Wiley, and WorldCat databases were systematically searched for articles published in the last 10 years. Studies involving participants with stages 4 and 5 ROP who underwent vitrectomy were included. The final search was performed on March 24, 2023. Risk of bias was assessed using the National Institutes of Health Quality Assessment Tool. The results were presented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Ten studies were included in the review. A total of 1179 eyes underwent vitrectomy (72% lens-sparing vitrectomy [LSV] and 28% lensectomy-vitrectomy [LV]). LSV was mainly performed in stage 4 ROP and LV in stage 5 ROP. Anatomical and functional successes were more significant in stages 4A and 4B than in stage 5. Factors that improved prognosis included no plus diseases, stage 4, prior treatments such as laser or intravitreal anti-vascular endothelial growth factor injection, and sparing the lens intraoperatively. Vitrectomy resulted in better outcomes in patients with stage 4 ROP. Early detection and a strict screening protocol are needed to prevent ROP progression into stage 5.
Whiplash Maculopathy Following Parachute Injury
Authors: Sen Parveen , Vaidya Harshit
Published: July 2024

Purpose: To report subtle yet important macular changes following a whiplash injury.
Case Report: We report an unusual case of a healthy young male presenting with a three-month history of a drop in vision in both eyes following an accident while crash-landing from a parachute. There was no direct ocular injury. Fundus examination revealed a bilateral well-defined area of retinal pigment epithelium (RPE) alterations over the macula with no other obvious retinal abnormality. Optical coherence tomography (OCT) examination revealed outer retinal layer defects with nearly intact inner retina.
Conclusion: This case highlights the importance of fundus evaluation and reviewing patient’s visual symptoms in otherwise inapparent ocular trauma.
Saúde sexual e reprodutiva de universitárias da área da saúde
Authors: Albino Júlia Camila , Miranda Parreira Bibiane Dias , Machado Ana Rita Marinho
Published: July 2024

Objetivo: identificar questões relacionadas à saúde sexual e reprodutiva de universitárias da área da saúde. Método: estudo quantitativo; transversal; exploratório e não experimental com acadêmicas de todos os cursos de graduação da área da saúde de uma universidade pública. Resultados: participaram 95 acadêmicas dos cursos de Enfermagem, Fisioterapia, Medicina, Nutrição e Biomedicina. A média de idade foi de 26 anos; 93,7% já tiveram relação sexual e não tinham filhos; 54,7% vão em consulta ginecológica uma vez ao ano; realizam o exame de papanicolaou em 76,8% delas; 48,4% afirmou uso da pílula anticoncepcional e 20% uso de preservativo masculino; 29,4% relataram candidíase e 7,3% vaginose bacteriana. Conclusão: os conhecimentos adquiridos durante a graduação podem ser influenciadores no cuidado na vida sexual e reprodutiva das acadêmicas pesquisadas.
Riscos ocupacionais na prática da equipe de enfermagem no Serviço de Atendimento Móvel de Urgência
Authors: Santos Denize Vieira dos , Alves Júnior Josivan Soares , Aragão Samara Farias , Silva Joyce Kell Sampaio da , Raposo Débora Regina Alves , Valle Lohanny Ingridh Moura
Published: July 2024

Objetivo: analisar os riscos ocupacionais enfrentados pela equipe de enfermagem que atua no Serviço de Atendimento Móvel de Urgência e quais são as medidas de contenção implementadas. Método: revisão Integrativa com a inclusão de estudos dos anos de 2018 a 2023. As buscas foram realizadas na National Library of Medicine e Scientifc Eletronic Library Online, Medical Literature Analysis and Retrieval System Online (MEDLINE/PUBMED) via National Library of Medicine e Scientifc Eletronic Library Online, com os descritores e os Medical Subject Headings: riscos ocupacionais, enfermagem e acidentes de trabalho; Occupational risks; Nursing; Accidents, Occupational; Work accidents; Riesgos laborales; Enfermería; Acidentes de trabajo, nas línguas portuguesa, inglesa e espanhola. Resultados: 298 artigos foram identificados inicialmente, desses, nove foram considerados como relevantes para este estudo e, a partir da análise foram construídas 10 categorias. Evidenciou-se que os riscos ocupacionais são considerados mais prevalentes na categoria profissional da equipe de enfermagem do Serviço de Atendimento Móvel em virtude de constituírem um processo complexo, e com determinantes fatores como stress e procedimentos de emergência/urgência, os quais têm sido potenciais motivadores de adoecimento, levando muitas vezes à exaustão da equipe. Conclusão: foi possível identificar diversos riscos ocupacionais entre os trabalhadores da categoria da enfermagem: físico, químico, psíquico e ergonômico, todos com significativa associação com acidentes de trabalho.
Visão de usuários da Atenção Primária à Saúde acerca de emergências cardiovasculares
Authors: Nascimento Caio Bruno Andrade , Silva Aline Teixeira , Pereira Vanessa Oliveira Silva , Carvalho Marco Túlio Menezes , Bernardes Elexandra Helena , Alves Mateus Goulart
Published: July 2024

Objetivo: constatar o quanto os fatores emocionais e empíricos influenciam na conduta de pessoas não treinadas em um evento cardiovascular súbito. Método: estudo transversal, realizado por meio de um questionário sobre fatores socioeconômicos, experiências prévias em situações emergenciais e condutas a serem tomadas diante de casos hipotéticos. Após, identificou-se as variáveis que se encontraram mais associadas à tomada de atitudes corretas. Realizou-se uma análise descritiva. Resultados: participaram 51 pessoas, das quais 14 (27,45%) afirmaram já ter participado de alguma formação em suporte básico de vida ou primeiros socorros e 37 (72,54%) afirmaram não participação. Daquelas que participaram, nove (64,28%) responderam corretamente o número do SAMU 192, e a porcentagem de pessoas que disseram saber realizar uma Ressuscitação Cardiopulmonar foi de 14,81% (nas pessoas que nunca presenciaram emergências) e 37,5% (grupo que já presenciou).  Conclusão: percebeu-se que, quanto mais uma pessoa é exposta a emergências ou recebe formações sobre suporte básico, maiores são as chances de reagir correta e calmamente em uma emergência.
Functional independence measure, sequelae, and comorbidities in individuals with COVID-19: a cross-sectional study
Authors: Martins Silva Lohanne Carolina , Grabaski Accioly Daniel , Otoni Oliveira Ana Carolina , Pereira Troncha de Castro Laianne Liliane , Porcatti Walsh Isabel Aparecida , Accioly Marilita Falangola
Published: July 2024

Objective: to verify whether there is loss of functionality and association between sequelae, comorbidities and between the Functional Independence Measure with sociodemographic data and clinical aspects in individuals affected by COVID-19. Method: this is a cross-sectional, descriptive, exploratory and quantitative study. Participants were contacted by telephone and answered a questionnaire covering sociodemographic and clinical aspects; post-COVID-19 sequelae, presence of comorbidities and Functional Independence Measure Scale. Results: 172 individuals participated with an average age of 41.42±14.21 years, 54.7% were female, 34.9% had comorbidities, 80.2% had post-COVID sequelae, 90.1% did not require hospitalization and 93.6% were vaccinated. The total Functional Independence Measure score was 120.73±11.3, corresponding to complete independence. There was an association between the cognitive domain and female sex (p=0.022) and white individuals (p=0.025), and between the motor domain, age between 18 and 59 years (p=0.014) and not being vaccinated against COVID-19 (p=0.046). Conclusion: comorbidities are associated with post-COVID-19 sequelae. Non-vaccinated individuals, when infected with COVID-19, may present impairment in the motor domain.
Probabilistic analysis of geological and structural Prospects for Oil and gas Potential in Western Yakutia Using three-Dimensional Empirical Mode Decomposition of Potential Fields
Authors: Kalinin D. F. , Dolgal A. S. , Voroshilov V. V.
Published: July 2024

Further development of modern formal approaches to extracting geo-structural information from gravimetric and magnetometric data is herein discussed. A practical example of using 3D GEMD (three-dimensional controlled empirical mode decomposition) algorithm to calculate potential fields transforms associated with the impact of deep and medium (of different ranks) geological structures on the adjacent territories of Western Yakutia was considered. Two types of reference groups were determined based on analysis of the known hydrocarbon fields in the Lena-Vilyuy and Lena-Tunguska oil and gas provinces. Statistical efficiency of the observed fields, fields’ area transforms (modified functions of empirical decomposition), and also spatially-linked combinations of the said attributes, aiming to solve the forecasting tasks, was determined. As a result of integration within the testing area, layout diagrams of deep geological and structural prerequisites for oil and gas potential, similar to group standards, were drawn up. A geological interpretation of forecasting and geophysical constructions is presented. It is shown that a number of identified areas predicted with high probabilities correlate with depressions of rift zones. Combined with thick volcanogenic-sedimentary formations, the latter forms most prospective oil and gas content pre-requisites.
Аналіз ключових показників ефективності роботи залізничних транспортних систем Network Rail і Infrabel
Authors: Попов Микита Дмитрович , Малахова Олена Анатоліївна , Сіконенко Григорій Михайлович , Шандер Олег Едуардович
Published: July 2024

Ефективність діяльності підприємства визначають за ступенем досягнення мети або позитивною  результативністю. У статті порівняно дві європейські залізничні системи з різними наборами критеріїв ефективності, наведено національні відмінності в оцінюванні ключових показників ефективності  функціонування залізниць, виділено складові концепції розвитку  інноваційного потенціалу залізничної транспортної системи. Показано, що для зручності аналізу показники ефективності підприємств  залізничного транспорту групують залежно від інфраструктурної та експлуатаційної складової транспортного процесу.Доведено, що формування різних підходів для оцінювання  ефективності функціонування залізничної системи дає змогу своєчасно виявляти проблемні місця на всіх ланках транспортного  процесу.
Аналіз методів керування випрямно-інверторного перетворювача електровоза
Authors: Нерубацький Володимир Павлович , Плахтій Олександр Андрійович , Івахно Володимир Вікторович , Гордієнко Денис Анатолійович , Шелест Дмитро Андрійович
Published: July 2024

У статті наведено дослідження  характеристик електромагнітної  сумісності в системі «електровоз -  контактна мережа». Проведено  аналіз впливу якості електричної  енергії на надійність і ресурс роботи  залізничних пристроїв та інших  об’єктів. Визнaчeно недоліки режиму роботи тиристорних випрямлячів у  статичних перетворювачах  електровозів однофазного змінного струму. Проведено моделювання різних режимів керування випрямно-інверторного перетворювача електровоза. Подано адаптивну систему різнофазного керування випрямно-інверторного  перетворювача із застосуванням діодного плеча, ввімкненого  паралельно колу випрямленого  струму, що дає змогу незалежно від місця розташування на фідерній зоні  максимально виконувати функцію зниження коефіцієнта гармонічних спотворень.
Метод визначення положення одновагонних відчепів у момент їхнього відриву від состава при розпуску з гірки
Authors: Куценко Максим Юрійович , Токаренко Сергій Олександрович , Вівдиченко Сергій Валентинович
Published: July 2024

Найважливішим параметром  сортувальної гірки є поздовжній профіль, від конструкції якого залежить продуктивність і безпека роботи всього сортувального  комплексу. Окремим завданням є  забезпечення відповідності  параметрів поздовжнього профілю гірок проєкту. У чинних правилах і нормах проєктування сортувальних пристроїв подано діапазони допустимих значень визначення конструктивних параметрів  перевальної частини гірок, при цьому методів і рекомендацій щодо визначення оптимальних значень не наведено. Отже, удосконалення  методів розрахунку параметрів  перевальної частини гірки є  актуальним напрямом наукових  досліджень. У статті розроблено  новий аналітичний метод  визначення положення одновагонних відчепів у момент  їхнього відриву від состава під час  розпуску з гірки, що забезпечує  точність розрахунків, порівнянну з імітаційним моделюванням. Результати досліджень можуть бути  використані при корегуванні норм  проєктування та утримання  сортувальних гірок.