bluuebunny/crossref_metadata_2025 huggingface dataset:
Solid‐Phase Oligosaccharide Synthesis of a Small Library of N‐Glycans
Authors: Jonke Simon , Liu Ke‐gang , Schmidt Richard R.
Published: November 2005

Solid‐phase oligosaccharide synthesis is based on a hydroxymethylbenzyl benzoate spacer linker which is connected to the Merrifield resin (1 P). Glycosylation was performed with O‐glycosyl trichloroacetimidates of glucosamine, mannose, and galactose permitting chain extension (2e, 5e), branching (4b, 7b, 8b), and chain termination (3t, 6t, 9t) with the use of O‐benzyl, O‐benzoyl, and N‐dimethylmaleoyl as permanent and O‐fluorenylmethoxycarbonyl (Fmoc) and O‐phenoxyacetyl (PA) as temporary protecting groups. The steps required on solid phase are i) glycosylation under TMSOTf catalysis, ii) selective cleavage of the temporary protecting groups, Fmoc with NEt3 and PA with 0.5 equivalents of NaOMe in CH2Cl2/MeOH, and iii) product cleavage from the resin with 4.0 equivalents of NaOMe in CH2Cl2/MeOH and following O‐acetylation for convenient product isolation. Thus a highly successful synthesis of a small library of seventeen N‐glycan structures was made possible comprising the N‐glycan pentasaccharide core structure 53 and two further chain extended hexa‐ and heptasaccharide N‐glycans with a glucosamine or a lactosamine residue, respectively, which is attached to one of the mannose residues of the core structure (56 and 59).
A New Approach to Enantiopure C3‐Symmetric Molecules
Authors: Castaldi M. Paola , Gibson Susan E. , Rudd Matthew , White Andrew J. P.
Published: November 2005

Chiral base chemistry has been used to create three chiral centres in one pot on a C3‐symmetric substrate. The potential of this new approach to C3‐symmetric molecules is exemplified by the creation of an enantiopure C3v‐symmetric triol, triphosphane and tripyridine. A ruthenium complex of the last compound has been studied by X‐ray crystallography.
Inequality of Quenched and High Temperature Structure of Lithium Deficient LiMn2O4.
Authors: Piszora P.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
The Influence of the Concentration of Sb Ions onto the Local Crystal and Electronic Structures of CuCr2‐xSbxS4 (x = 0.3, 0.4, 0.5) Studied by XANES and EXAFS Measurements and LAPW Numerical Calculations.
Authors: Zajdel P. , et al. et al.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
A Flexible and Versatile Strategy for the Covalent Immobilization of Chiral Catalysts Based on Pyridinebis(oxazoline) Ligands.
Authors: Cornejo Alfonso , Fraile Jose M. , Garcia Jose I. , Gil Maria J. , Luis Santiago V. , Martinez‐Merino Victor , Mayoral Jose A.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Sterically‐Controlled Regioselective para‐Substitutions of Aniline.
Authors: Dyer Philip W. , Fawcett John , Griffith Gerald A. , Hanton Martin J. , Olivier Celine , Patterson Adam R. , Suhard Samuel
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Acyclic Amino Acid‐Catalyzed Direct Asymmetric Aldol Reactions: Alanine, the Simplest Stereoselective Organocatalyst.
Authors: Cordova Armando , Zou Weibiao , Ibrahem Ismail , Reyes Efraim , Engqvist Magnus , Liao Wei‐Wei
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Reaction of 1,3‐Dicarbonyl Compounds with o‐Phenylenediamine or 3,3′‐Diaminobenzidine in Water or under Solvent‐Free Conditions via Microwave Irradiation.
Authors: Wang Zhong‐Xia , Qin Hua‐Li
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Addition of Nitrogen Pronucleophiles to Alkylidenecyclopropanes.
Authors: Siriwardana Amal I. , Kamada Michiru , Nakamura Itaru , Yamamoto Yoshinori
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
First Application of Ionic Liquid to Reactions Involving Organotellurium Compounds as Intermediates.
Authors: Wang Lei , Huang Zhizhen
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Catalytic Tricarbonylation of Alkynes with Palladium Catalysts.
Authors: Izawa Yusuke , Shimizu Isao , Yamamoto Akio
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
A New Method for the Synthesis of Carboxylic Esters and Lactones with Di‐2‐thienyl Carbonate (2‐DTC) by the Promotion of DMAP and Iodine.
Authors: Oohashi Yoshiaki , Fukumoto Kentarou , Mukaiyama Teruaki
Published: November 2005

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Mild One‐Pot Conversion of Carboxylic Acids to Amides or Esters with Ph3P/Trichloroisocyanuric Acid.
Authors: Rodrigues Rogerio da C. , Barros Igor M. A. , Lima Edson L. S.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Heteroaryl Manganese Reagents: Direct Preparation and Reactivity Studies.
Authors: Rieke Reuben D. , Suh YoungSung , Kim Seung‐Hoi
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Nucleophilic Addition to Acetylenes in Superbasic Catalytic Systems. Part 8. Fluoride Cesium Containing Systems, Efficient Catalysts for Alkanols Vinylation.
Authors: Oparina L. A. , Shaikhudinova S. I. , Parshina L. N. , Vysotskaya O. V. , Preiss Th. , Henkelmann J. , Trofimov B. A.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
1,4‐Conjugate Additions of Methoxyamine and 1,1‐Dimethylhydrazine to Hex‐3‐yne‐2‐one: A Facile Synthesis of Functionalized Isoxazole and Pyrazole Precursors.
Authors: Sauers Ronald R. , Van Arnum Susan D.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
New Approach to the Synthesis of trans‐Aconitic Acid Imides.
Authors: Martynov A. V.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Facile Conversion of Alcohols into Esters and Dihydrogen Catalyzed by New Ruthenium Complexes.
Authors: Zhang Jing , Leitus Gregory , Ben‐David Yehoshoa , Milstein David
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
An Efficient Method for Alkylation of Alcohols with Alkyl P,P‐Diphenyl‐N‐(methanesulfonyl)phosphinimidates.
Authors: Aoki Hidenori , Mukaiyama Teruaki
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Simple Procedure for the Synthesis of Arylmethylenemalononitrile Without Catalyst.
Authors: Wang Xiang‐Shan , Zeng Zhao‐Sen , Li Yu‐Ling , Shi Da‐Qing , Tu Shu‐Jiang , Wei Xian‐Yong , Zong Zhi‐Min
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
CuI‐Catalyzed Intramolecular O‐Vinylation of Carbonyl Compounds.
Authors: Fang Yewen , Li Chaozhong
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
A New Type of Uniformly Stacked Phase in Tetrathiapentalene‐Based Organic Metals.
Authors: Bando Yoshimasa , Matsuzawa Takahiro , Takashita Norihiro , Kawamoto Tadashi , Mori Takehiko , Yamada Jun‐ichi
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Stereoselective Construction of cis‐2,6‐Disubstituted Tetrahydropyrans via an Intramolecular Bismuth‐Mediated Oxa‐Conjugate Addition Reaction.
Authors: Evans P. Andrew , Andrews William J.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of New 8‐Arylisoquinoline Derivatives by Application of Palladium‐Catalyzed Suzuki Cross‐Coupling Reactions.
Authors: Andreu Immaculada , Cabedo Nuria , Fabis Frederic , Cortes Diego , Rault Sylvain
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Fluorine‐Containing Heterocycles. Part 2. Synthesis and Reactions of New Thieno[2,3‐b]pyridine Derivatives Bearing Trifluoromethyl Group.
Authors: Abdel‐Rahman Abdu E. , Bakhite Etify A. , Al‐Taifi Elham A.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Selective Nucleophilic Replacement of the Benzylsulfanyl Group in 2,4‐Disulfanyl‐substituted Thieno[2,3‐d]pyrimidin‐6‐carboxylic Acid Derivatives by Secondary Amines.
Authors: Briel Detlef , Drescher Simon , Dobner Bodo
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
An Asymmetric ent‐Kauranoid Dimer from Isodon rubescens var. lushanensis.
Authors: Han Quan‐Bin , Lu Yang , Wu Li , He Zhen‐Dan , Qiao Chun‐Feng , Xu Hong‐Xi , Zheng Qi‐Tai , Sun Han‐Dong
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Template Synthesis of Peptidomimetics Composed of Aspartic Acid Moiety by Ugi Four‐Component Condensation Reaction.
Authors: Zhang Xin , Zou Xiaomin , Xu Ping
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Stripping off Water at Ambient Temperature: Direct Atom‐Efficient Acetal Formation Between Aldehydes and Diols Catalyzed by Water‐Tolerant and Recoverable Vanadyl Triflate.
Authors: Chen Chien‐Tien , Weng Shiue‐Shien , Kao Jun‐Qi , Lin Chun‐Cheng , Jan Mi‐Dan
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Annulation of Pyrrole: Application to the Synthesis of Indolizidine Alkaloids.
Authors: Amos Ruth I. J. , Gourlay Brendon S. , Molesworth Peter P. , Smith Jason A. , Sprod Owen R.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
An Efficient Route for Commercially Viable Syntheses of Furan‐ and Thiophene‐Anellated β‐Hydroxychalcones.
Authors: Yadav Prem P. , Ahmad Ghufran , Maurya Rakesh
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Biosynthetic Capacities of Actinomycetes. Part 34. Novel Marine Natural Products. Part 8. Gephyromycin, the First Bridged Angucyclinone, from Streptomyces griseus Strain NTK 14
Authors: Bringmann Gerhard , et al. et al.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Surfactant‐Free Hydrothermal Synthesis of Lithium Aluminate Microbricks and Nanorods from Aluminum Oxide Nanoparticles.
Authors: Joshi Upendra A. , Chung Soo Hyun , Lee Jae Sung
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Transition Metals in Atmospheric Liquid Phases. Sources, Reactivity, and Sensitive Parameters
Authors: Deguillaume Laurent , Leriche Maud , Desboeufs Karine , Mailhot Gilles , George Christian , Chaumerliac Nadine
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Collective Spin and Charge Excitations in (Sr,La)14‐xCaxCu24O41 Quantum Spin Ladders
Authors: Gozar A. , Blumberg G.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Commensurate and Incommensurate Magnetism in Layered Antiferromagnets
Authors: Chovan J. , Papanicolaou N.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Functional Microporous Materials of Metal Carboxylate: Gas‐Occlusion Properties and Catalytic Activities
Authors: Mori Wasuke , Sato Tomohiko , Ohmura Tesushi , Nozaki Kato Chika , Takei Tohru
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Analytical Aspects of Organolithium Compounds
Authors: Zabicky Jacob
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Effects of Structural Variation on Organolithium Compounds
Authors: Charton Marvin
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Recent Advances in Catalytic Asymmetric Hydrogenation: Renaissance of the Monodentate Phosphorus Ligands
Authors: Guo Hongchao , Ding Kuiling , Dai Lixin
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Carbohydrates as Versatile Platforms in the Construction of Small Compound Libraries
Authors: Timmer Mattie S. M. , Verhelst Steven H. L. , Grotenbreg Gijsbert M. , Overhand Mark , Overkleeft Herman S.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Strategies for Total and Diversity‐Oriented Synthesis of Natural Product(‐like) Macrocycles
Authors: Wessjohann Ludger A. , Ruijter Eelco
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
The Kinetics and Energy Balance of Mechanochemical Transformations
Authors: Butyagin P. Yu. , Streletskii A. N.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Ubiquitin at Fox Chase (Nobel Lecture)
Authors: Rose Irwin
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Gaussian Basis Sets for Some Polyatomic Two‐Heavy‐Atom Hydrides
Authors: Pires Jose M. , Jorge F. E.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Crystal Growth, Structural Transitions, and Magnetic Properties of the Fluorite‐Related Osmates: Sm3OsO7, Eu3OsO7, and Gd3OsO7.
Authors: Gemmill William R. , Smith Mark D. , Mozharivsky Yurij A. , Miller Gordon J. , zur Loye Hans‐Conrad
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Ln18Li8Rh5O39 (Ln: La, Pr): A Mixed‐Metal Oxide with a Charge‐Ordered Arrangement of Rh3+ and Rh4+.
Authors: Frampton Philip P. C. , Battle Peter D. , Ritter Clemens
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Compounds Ln5(Ag, Ga)19‐x (Ln: Gd, Tb) — Defective Partially Ordered Representatives of the Rb5Hg19 Structure Type.
Authors: Gumeniuk Roman V. , Akselrud Lev G. , Kuz'ma Yurij B.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Monoclinic La1‐xBaxMnO3 (x = 0.185) at 160 K.
Authors: Rotiroti Nicola , Tamazyan Rafael , van Smaalen Sander , Mukovskii Ya.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Octahedral—Tetrahedral Framework Structures of InAsO4×H2O and PbIn(AsO4)(AsO3OH).
Authors: Kolitsch Uwe , Schwendtner Karolina
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Enantioselective Hydrogenation of Allylphthalimides: An Efficient Method for the Synthesis of β‐Methyl Chiral Amines.
Authors: Wang Chun‐Jiang , Sun Xianfeng , Zhang Xumu
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Highly Regio‐, Chemo‐ and Diastereoselective Synthesis of Oxa‐Bridged Spirocycles: A Novel Observation of Reverse Selectivity.
Authors: Muthusamy Sengodagounder , Krishnamurthi Janagiraman , Nethaji Munirathnam
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Engaging Morita—Baylis—Hillman Reaction for the Generation of Isobenzofuran and the Consequent Entry into Highly Substituted Aromatic Systems.
Authors: Nair Vijay , Abhilash K. G.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis, Characterization and Structure of a Tetrameric DABCO—Bromine Complex: A Novel Oxidizing Agent for Oxidation of Alcohols to Carbonyl Compounds.
Authors: Heravi Majid M. , Derikvand Fatemeh , Ghassemzadeh Mitra , Neumueller Bernhard
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Preparation of N‐Chloroamides Using Trichloroisocyanuric Acid.
Authors: Hiegel Gene A. , Hogenauer Tyrone J. , Lewis Justin C.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Mercurous Chloride Catalyzed Mannich Condensation of Terminal Alkynes with Secondary Amines and Aldehydes.
Authors: Ll Pin‐Hua , Wang Lei
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Metalation of Sulfoxides in the Benzodiazine Series. Diazines. Part 44.
Authors: Le Fur Nicolas , Mojovic Ljubica , Ple Nelly , Turck Alain , Marsais Francis
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Chromium‐Mediated Fluoroalkenylation Reactions of 1,1‐Dibromo‐1‐fluoroalkane and 1‐Bromo‐1‐fluoroalkene Derivatives.
Authors: Saito Akio , Nakagawa Muga , Taguchi Takeo
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Highly Regio‐ and Enantioselective Asymmetric Hydroformylation of Olefins Mediated by 2,5‐Disubstituted Phospholane Ligands.
Authors: Axtell Alex T. , Cobley Christopher J. , Klosin Jerzy , Whiteker Gregory T. , Zanotti‐Gerosa Antonio , Abboud Khalil A.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Nucleophilic Addition to Acetylenes in Superbasic Catalytic Systems. Part 14. Vinylation of Diols in a System CsF—NaOH.
Authors: Oparina L. A. , Khil'ko M. Ya. , Chernyshova N. A. , Shaikhudinova S. I. , Parshina L. N. , Preiss Th. , Henkelmann J. , Trofimov B. A.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Cyclopropyl Building Blocks for Organic Synthesis. Part 112. Titanium‐Mediated Cyclopropanation of N,N‐Dibenzylcarboxamides Towards Functionally Substituted 2‐(1′‐Aminocyclopropyl)acetic Acids.
Authors: Brackmann Farina , de Meijere Armin
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Organocatalysis Using Protonated 1,2‐Diamino‐1,2‐diphenylethane for Asymmetric Diels—Alder Reaction.
Authors: Kim Kyoung Hoon , Lee Seil , Lee Dae‐Woong , Ko Dong‐Hyun , Ha Deok‐Chan
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Biologically Active Substances Based on Phenoxyethanol Derivatives.
Authors: Kukovinets O. S. , Yamansarova E. T. , Kasradze V. G. , Lozhkina E. A. , Zainullin R. A. , Abdullin M. I.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Facile Synthesis of Aryl‐ and Alkyl‐bis(trifluoromethylsulfonyl)methanes.
Authors: Hasegawa Aiko , Ishikawa Takuo , Ishihara Kazuaki , Yamamoto Hisashi
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Phosphine‐Free Palladium Acetate Catalyzed Suzuki Reaction in Water.
Authors: Liu Leifang , Zhang Yuhong , Wang Yanguang
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Pd—EDTA as an Efficient Catalyst for Suzuki—Miyaura Reactions in Water.
Authors: Korolev Dmitrii N. , Bumagin Nikolay A.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Rare Earth(III) Perfluorooctane Sulfonates and Perfluorooctanesulfonic Acid in Fluorous Solvents: Novel and Recyclable Catalytic Systems for Friedel—Crafts Acylation of Unactivated Benzenes.
Authors: Yi Wen‐Bin , Cai Chun
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
3,5‐Bis(trifluoromethyl)phenyl Sulfones in the Direct Julia—Kocienski Olefination.
Authors: Alonso Diego A. , Fuensanta Monica , Najera Carmen , Varea Montserrat
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
New α‐Methylene‐γ‐butyrolactones with Antimycobacterial Properties.
Authors: Hughes Minerva A. , McFadden Jill M. , Townsend Craig A.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Synthesis of 3,3‐Disubstituted Isoindolinones.
Authors: Comins Daniel L. , Hiebel Anne‐Cecile
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Indole‐ and Indoline‐Based Kainate Analogues with Antagonist Activity at Ionotropic Glutamate Receptors.
Authors: Shou Xiaohong , Miledi Ricardo , Chamberlin A. Richard
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and SAR of Novel Oxazolidinones: Discovery of Ranbezolid.
Authors: Das Biswajit , et al. et al.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
A Mild and Efficient Synthesis of 5‐Oxo‐5,6,7,8‐tetrahydro‐4H‐benzo‐[b]‐pyran Derivatives in Room Temperature Ionic Liquids.
Authors: Jiang Zhao‐Qin , Ji Shun‐Jun , Lu Jun , Yang Jin‐Ming
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Molecular Iodine Catalyzed One‐Pot Synthesis of 4‐Substituted‐1,4‐dihydropyridine Derivatives via Hantzsch Reaction.
Authors: Ko Shengkai , Sastry M. N. V. , Lin Chunchi , Yao Ching‐Fa
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
High Throughput Synthesis of Pyrazolopyrimidines via Copper‐Catalyzed Cyclization and X‐Ray Study.
Authors: Abdel‐Jalil Raid J. , Khanfar Monther , Al‐Gharabli Samer , El‐Abadelah Mustafa M. , Eichele Klaus , Anwar Muhammad Usman , Voelter Wolfgang
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
A Selective Synthesis of 3,6‐Dihydro‐7H‐1,2,3‐triazolo[4,5‐d]pyrimidin‐7‐ones.
Authors: Zhao Jun‐Feng , Xie Chang , Ding Ming‐Wu , He Hong‐Wu
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
An Expedient Method for the Synthesis of 6‐Substituted Uracils under Microwave Irradiation in a Solvent‐Free Medium.
Authors: Devi Ipsita , Bhuyan Pulak J.
Published: November 2005

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Selective Synthesis and Cycloaddition Reactions of New Azomethine Imines Containing a 1,2,4‐Triazine Ring.
Authors: Grof Csilla , Hegedus Gabor , Riedl Zsuzsanna , Hajos Gyoergy , Egyed Orsolya , Csampai Antal , Kudar Veronika , Stanovnik Branko
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Second Generation N‐Heterocyclic Carbene—Pt(0) Complexes as Efficient Catalysts for the Hydrosilylation of Alkenes.
Authors: Buisine Olivier , Berthon‐Gelloz Guillaume , Briere Jean‐Francois , Sterin Sebastien , Mignani Gerard , Branlard Paul , Tinant Bernard , Declercq Jean‐Paul , Marko Istvan E.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Microwave‐Assisted One‐Pot Synthesis of α‐Amino Phosphonates via Three Component Coupling on a Silica Gel Support.
Authors: Zhan Zhuang‐Ping , Yang Rui‐Feng , Li Jun‐Ping
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Convenient Preparation of Diethyl (2‐Thienyl)methanephosphonate.
Authors: Davis Matthew C.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Convenient Palladium‐Catalyzed Arsination: Direct Synthesis of Functionalized Aryl Arsines, Optically Active As,N Ligands, and Their Metal Complexes.
Authors: Kwong Fuk Yee , Lai Chi Wai , Yu Michael , Tan Duan‐Ming , Lam Fuk Loi , Chan Albert S. C. , Chan Kin Shing
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Novel Strategies for the Preparation of Aminocarbasugar Analogues: Syntheses of N‐Substituted Aminocyclitols from D‐Mannose.
Authors: Gomez Ana M. , Moreno Eduardo , Uriel Clara , Jarosz Slawomir , Valverde Serafin , Lopez J. Cristobal
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
New Sesquicillins, Insecticidal Antibiotics Produced by Albophoma sp. FKI‐1778
Authors: Uchida Ryuji , Imasato Rie , Yamaguchi Yuichi , Masuma Rokuro , Shiomi Kazuro , Tomoda Hiroshi , Omura Satoshi
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of a sec‐Precursor and Analogues of Macrolactin A.
Authors: Xiao Xiangshu , Li Shukun , Yan Xuebin , Liu Xuejun , Xu Rui , Bai Donglu
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
New 24‐Membered Macrolides SPA‐6952A and B Produced by Streptomyces sp.
Authors: Hosotani Nobuo , Kumagai Kazuo , Nakagawa Hiroyuki , Shimatani Takuro , Saji Ikutaro
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Fluorinated Pyridine Derivatives. Part 1. The Synthesis of Some Mono‐ and Bis‐quaternary Pyridine Salts of Potential Use in the Treatment of Nerve Agent Poisoning.
Authors: Timperley Christopher M. , Bird Mike , Heard Suzannah C. , Notman Stuart , Read Robert W. , Tattersall John E. H. , Turner Simon R.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Structure—Property Relationship of Permutite‐Like Amorphous Silicates, Nax+2yM3+xSi1‐xO2+y (M3+: Al, Mn, Fe, Y), for Ion‐Exchange Reactions.
Authors: Pless Jason D. , Maxwell Robert S. , Philips Mark L. F. , Helean Katheryn B. , Axness Marlene Y. , Nenoff Tina M.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Mixed Crystalline Precursor Complexes of the Type [Ba(C2H6O2)4] [Ti1‐xSnx (C2H4O2)3] (x = 0—1) for BaTi1‐xSnxO3 Ceramics: Synthesis, Structure and Calcination.
Authors: Koeferstein Roberto , Jaeger Lothar , Lorenz Volker , Abicht Hans‐Peter , Woltersdorf Joerg , Pippel Eckhard , Goerls Helmar
Published: November 2005

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The Chemistry of Phosphanyl‐Ferrocenecarboxylic Ligands
Authors: Stepnicka Petr
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Photochromism of Diarylethene Single Crystals: Crystal Structures and Photochromic Performance
Authors: Morimoto Masakazu , Irie Masahiro
Published: November 2005

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Construction of Carbocycles via Zirconacycles and Titanacycles
Authors: Xi Zhenfeng , Li Zhiping
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Reactions of Ion‐Pair Intermediates of Solvolysis
Authors: Tsuji Yutaka , Richard John P.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
1‐Alkoxyvinyl Esters: Renaissance of Half‐Century‐Old Acyl Donors with Potential Applicability
Authors: Kita Yasuyuki , Akai Shuji
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Utility of Microwaves as New Methodology for Electron Transfer Reactions
Authors: Gellis Armand , Rathelot Pascal , Crozet Michel P. , Vanelle Patrice
Published: November 2005

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Regioselectivity Control and SRN1 Reactivity in Quinonic Series
Authors: Giraud Luc , Giraud Anne , Terme Thierry , Vanelle Patrice
Published: November 2005

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Enamine‐Based Reactions Using Organocatalysts: From Aldolase Antibodies to Small Amino Acid and Amine Catalysts
Authors: Tanaka Fujie , Barbas Carlos F. III
Published: November 2005

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Syntheses of Carbosilane Dendrimers Carrying Peripheral Globotriaose Derivatives — The Relationship Between the Carbosilane Dendrimer Structure and the Magnitude for Neutralizing Shiga Toxin‐Producing Escherichia coli O157:H7
Authors: Terunuma Daiyo , Matsuoka Koji , Hatano Ken
Published: November 2005

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Structure‐Based Inhibitor Design of Human Hematopoietic Prostaglandin D Synthase
Authors: Inoue Tsuyoshi , Kai Yasushi , Urade Yoshihiro
Published: November 2005

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The Conjugate Addition of Enantiomerically Pure Lithium Amides as Homochiral Ammonia Equivalents: Scope, Limitations, and Synthetic Applications
Authors: Davies Stephen G. , Smith Andrew D. , Price Paul D.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Unsymmetrical Azaporphyrins: Synthesis, Structure, and Properties
Authors: Maizlish V. E. , Kulinich V. P. , Shaposhnikoy G. P.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Diastereoselective Alkylation of cyclo‐β‐Dipeptides en route to Enantiopure β‐Amino Acids
Authors: Juaristi Eusebio , Avina Judit
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Aryl Nucleoside H‐Phosphonates: Versatile Intermediates in the Synthesis of Nucleotides and Their Analogues
Authors: Kraszewski Adam , Stawinski Jacek
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Starch Retrogradation
Authors: Ottenhof Marie‐Astrid , Farhat Imad A.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Liquid‐Phase Synthesis of Polyamide Nucleic Acids (PNA): Applications in Targeting Specific Viral RNA Sequences
Authors: Di Giorgio C. , Depecker G. , Schwergold C. , Leroux M. L. , Caldarelli S. , Di Giorgio A. Farese , Patino N. , Condom R.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
The Structure, Biological Activities and Synthesis of 3‐ Hydroxylpyrrolizidine Alkaloids and Related Compounds
Authors: Pyne Stephen G. , Tang Minyan
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Application of the Carbene Cyclization—Cycloaddition Cascade in Total Synthesis
Authors: Chiu Pauline
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Syntheses of Antiangiogenic or Cytotoxic Natural Products: Fumagillin and Bengacarboline
Authors: Bedel O. , Haudrechy A. , Pouilhes A. , Langlois Y.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Metalated Calixarenes and Cyclotriveratrylenes as Anion Hosts
Authors: Holman K. Travis , Atwood Jerry L.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Multiple Modes of Active Center Communication in Thiamin Diphosphate‐Dependent Enyzmes
Authors: Jordan Frank , Nemeria Natalia S. , Sergienko Eduard
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Multivalency and Cooperativity in Supramolecular Chemistry
Authors: Badjic Jovica D. , Nelson Alshakim , Cantrill Stuart J. , Turnbull W. Bruce , Stoddart J. Fraser
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Velocity Modulation Spectroscopy of Ions
Authors: Stephenson Serena K. , Saykally Richard J.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Chromatographic analysis of allosteric effects between ibuprofen and benzodiazepines on human serum albumin
Authors: Chen Jianzhong , Fitos Ilona , Hage David S.
Published: November 2005

The effects of (R)‐ and (S)‐ibuprofen on the binding of benzodiazepines to human serum albumin (HSA) were examined by biointeraction chromatography. The displacement of benzodiazepines from HSA by (R)‐ and (S)‐ibuprofen was found to involve negative allosteric interactions (or possible direct competition) for most (R)‐benzodiazepines. However, (S)‐benzodiazepines gave positive or negative allosteric effects and direct competition when displaced by (R)‐ or (S)‐ibuprofen. Association equilibrium constants and coupling constants measured for these effects indicated that they involved two classes of ibuprofen binding regions (i.e., low‐ and high‐affinity sites). Based on these results, a model was proposed to explain the binding of benzodiazepines to HSA and their interactions with ibuprofen. This model gave good agreement with previous reports examining the binding of benzodiazepines to HSA. © 2005 Wiley‐Liss, Inc. Chirality
Chiral Recognition of Carboxylic Acids by Chiral Nitrogen Containing Calix[4]arene
Authors: Zheng Yan‐Song , Xiao Qin
Published: November 2005

Chiral nitrogen‐containing calix[4]arene was easily synthesized by the reaction of 25,27‐di(2‐bromoethoxy)‐26,28‐dihydroxy‐5,11,17,23‐tetrakis(t‐butyl)calix[4]arene with S‐((−)‐1‐phenylethylamine in excellent yield, and showed good ability to recognize the enantiomers of mandelic acid and 2,3‐dibenzoyltartaric acid. This finding has potential application to assay and separation of enantiomers of the carboxylic acids.
Novel Pd/TiO2‐Al2O3 Catalysts for Methane Total Oxidation at Low Temperature and Their 18O‐Isotope Exchange Behavior
Authors: Lin Wei , Lin Li , Zhu Yue‐Xiang , Xie You‐Chang , Scheurell K. , Kemnitz E.
Published: November 2005

Pd supported on TiO2‐Al2O3 binary oxides prepared by coprecipitation method has been investigated for the total oxidation of methane. All Pd/TiO2‐Al2O3 catalysts show higher activity than Pd/Al2O3 and Pd/TiO2. Among them, Pd/2Ti‐3Al with a Ti/Al ratio of 2 to 3 has a T90% of 395 °C at a gas hourly mass velocity of 33000 mL/(h·g), which is at least 50 °C lower than that of Pd supported on single metal oxide Al2O3 or TiO2. The results of TPR and 18O‐isotope exchange experiments demonstrated that the excellent activity of Pd/2Ti‐3Al was due to its high oxygen mobility and moderate reducibility, which is in accordance with our previous work. XPS results indicated that the dispersion of Pd was not the key factor to influence the catalytic activity.
Self‐assembly of Two Novel Supramolecular Frameworks Based on Flexible Oligo‐α‐Pyridylamino Ligands and Copper(II) Maleate
Authors: Zhou Cai‐Hua , Wang Yao‐Yu , Zhou Li‐Jun , Liu Ping , Li Dong‐Sheng , Shi Qi‐Zhen
Published: November 2005

Two novel supramolecular complexes, [Cu(bpapa)(mal)]·H2O·CH3OH (1) and {[Cu(bpapap)](Hmal)2}·2H2O (2) [bpapa=bis‐[6‐(2‐pyridylamino)pyrid‐2‐yl]amine, bpapap=2,6‐bis‐[6‐(pyrid‐2‐ylamino)pyrid‐2‐ylamino]‐pyridine, mal=maleate dianion] were rationally designed and synthesized based on flexible multidentate ligands and copper(II) maleate. Complexes 1 and 2 were all characterized by elemental analysis, spectroscopic techniques, thermal analysis and single crystal X‐ray diffraction analysis. Complex 1 is of an infinite 3‐D supramolecular framework constructed by 2‐D sheets to contain 1‐D helical chains formed by intermolecular hydrogen bond interactions between the non‐coordinated oxygen atoms from maleate and nitrogen atoms from amino groups of bpapa. Complex 2 also takes a 3‐D supramolecular structure, which is built from 2‐D rhombic sheets produced by sequential dimer units. Interestingly, three pairs of symmetrical hydrogen bonds generate these dimer units.
Preparation, Structural Characterization and Thermal Decomposition Mechanism of [Cu(TO)2(H2O)4](PA)2
Authors: Zhang Jian‐Guo , Zhang Tong‐Lai , Liu Yan‐Hong
Published: November 2005

[Cu(TO)2(H2O)4](PA)2 was prepared by the reaction of aqueous 1,2,4‐triazol‐5‐one (TO) solution with the solution of copper picrate Cu(PA)2 and characterized by elemental analysis, FT IR and X‐ray powder diffraction analysis. The title complex has been studied by means of TG‐DTG and DSC under conditions of linear temperature increase. The thermal decomposition residues were examined by FT IR analysis. Thermal decomposition mechanism of the title complex was proposed. In the temperature range of 30–680 °C, the thermal decomposition process was composed of four major stages. The first stage was an endothermic process with the loss of four coordination water molecules. Since the dehydration product was unstable, when it was heated, it would be decomposed much more easily. The second stage was composed of an acute endothermic process and a continued strong exothermic process and the main decomposed residues were CuCO3, Cu(NCO)2 and polymers during this stage. The third stage was a sharp exothermic process, which resulted from the decomposition of the polymer. After the forth stage, the final decomposed residues were certainly copper oxide. The Arrhenius parameters have been also studied on the dehydration process and the first‐step exothermic decomposition of [Cu(TO)2(H2O)4](PA)2 using Kissinger's method and Ozawa‐Doyle's method. The results using both methods were consistent with each other. The Arrhenius equation can be expressed as ln k=24.0–179.8×103/RT for the dehydration process and ln k=16.7–206.0×103/RT for the first‐step exothermic decomposition, on the basis of the average of Ea and ln A through the two methods.
Syntheses, Structures and Antibacterial Activities of Two Nickel(II) Complexes with N‐Hexanoylsalicylhydrazide Ligand
Authors: Yang Ming‐Xing , Lin Shen , Yu Ping , Chen Li‐Juan , Liu Shi‐Xiong
Published: November 2005

The two trinuclear nickel(II) complexes, Ni3(C13H15N2O3)2(C5H5N)4 (1) and Ni3(C13H15N2O3)2(C5H5N)2‐ (C3H7NO)2 (2), were prepared by the reaction of Ni(OAc)2·4H2O with N‐hexanoylsalicylhydrazide. The crystal structures of complexes were determined by X‐ray diffraction analysis. Complex 1 takes triclinic symmetry with space group P‐1 and cell dimensions of a=0.92377(2) nm, b=1.08786(6) nm, c=1.29391(3) nm, α=76.395(4) °, β=78.418(3)°, γ=67.378(4)°, V=1.15772(7) nm3, Z=1, µ=12.63 cm−1. Complex 2 belongs to triclinic system and P2(1) space group and the crystallographic data: a=1.4889(2) nm, b=1.0389(1) nm, c=1.4994(2) nm, β=96.174(4)°, V=2.3058(5) nm3, Z=2, µ=12.70 cm−1. The structures of the two molecules are similar. The three nickel atoms in each molecule of the two title complexes arrange in a strictly linear structure. The central nickel atom of the molecule adopts octahedral configuration, while the two nickel atoms on the two sides adopt square‐planar configuration in each molecule. But the central nickel atoms of the two complexes have different axial ligands, which cause a slight difference in the bond distances of the octahedron. The antibacterial activity of compound 1 against seven common bacteria was investigated.
The First Total Synthesis of Phebaclavin A and C
Authors: Zhang Yu , Liu Dong , Li Yang , Cao Xiao‐Ping
Published: November 2005

Phebaclavin A (1) and C (2) were synthesized in 60% and 58% total yields over 5 steps from commercially available starting meterials respectively. The synthesis feature was usage of the Wittig reaction twice and solvent‐free cyclizing reaction as the key steps.
Chiral Oxazaborolidine‐catalyzed Asymmetric Borane Reduction of Alkyl 4‐Dialkylaminophenyl Ketones
Authors: Xu Jia‐Xi , Lan Yu , Wei Tie‐Zheng , Zhang Qi‐Han
Published: November 2005

A series of alkyl 4‐dialkylaminophenyl ketones were prepared and reduced asymmetrically by borane under the chiral oxazaborolidine catalysis. The results indicate that the ketones show a more obvious substituent effect on the enantioselectivity than the corresponding 4‐alkyl/alkoxy/alkylthiophenyl ketones in the asymmetric reduction because of the existence of a strong coordinate nitrogen atom with the boron atom in the catalyst and borane.
Aufklärung tut Not: Gefährliche Peroxide
Authors: Obendrauf Viktor
Published: November 2005

Die im Folgenden thematisierten Fakten sind ausschließlich als Informationen für Lehrkräfte zu verstehen (siehe auch [1]). Von der Weitergabe dieses Beitrages im Rahmen von Facharbeiten an Lernende wird explizit abgeraten.
Die Erklärung der Brownschen Bewegung durch Einstein, Smoluchowski und Perrin
Authors: Jansen Walter
Published: November 2005

Über Albert Einstein, geboren am 14. März 1879 in Ulm und gestorben vor fünfzig Jahren am 18. April 1955 in Princeton (USA), ist gerade in diesem „Jubiläumsjahr”︁ ausführlichst geschrieben und berichtet worden. Denn es jährte sich nicht nur zum fünfzigsten Mal Einsteins Todesjahr, es ist auch genau 100 Jahre her, dass drei die Wissenschaft bewegende Arbeiten erschienen:

˙Zur Theorie der Lichtquanten: Über einen die Erzeugung und Umwandlung des Lichtes betreffenden heuristischen Standpunkt [1]

˙Zur Erklärung der Brownschen Bewegung: Über die von der molekularkinetischen Theorie der Wärme geforderte Bewegung von in ruhenden Flüssigkeiten suspendierten Teilchen [2] und die

˙Spezielle Relativitätstheorie Zur Elektrodynamik bewegter Körper [3].

Einsteins Tätigkeit im Schweizer Patentamt in Bern, wo er ab dem 16. Juni 1902 als Experte III. Klasse angestellt war, ließ ihm offensichtlich sehr viel Zeit, sich tiefschürfend mit wissenschaftlichen Fragestellungen zu beschäftigen.
Estimating late adverse events using competing risks after autologous stem‐cell transplantation in aggressive non‐Hodgkin lymphoma patients
Authors: Ruiz‐Soto Rodrigo , Sergent Guillaume , Gisselbrecht Christian , Larghero Jerome , Ertault Marjan , Hennequin Christophe , Manson Julien , de Kerviler Eric , Briere Josette , Mounier Nicolas
Published: November 2005

BACKGROUND

Consolidative autologous stem‐cell transplantation (ASCT) is a valuable option in high‐risk or disease recurrence large‐cell non‐Hodgkin lymphoma patients (NHL); however, its long‐term toxicity must still be assessed.

METHODS

Among the 439 lymphoma patients transplanted at our institution from January 1, 1993, to January 1, 2002, 158 exhibited aggressive NHL. The median age of the patients was 46 years (range, 18–69), 98 males and 60 females. Ninety (57%) patients received first‐line ASCT. The median number of prior chemotherapy regimens was 2 (range, 1–10). Thirty‐eight (24%) patients received total body irradiation conditioning. Here we report the adverse events which occurred at least 30 days after ASCT and before disease recurrence.

RESULTS

After a median follow‐up of 3 years, the overall and disease‐free survival rates were 61% and 55%, respectively. Sixty‐eight late adverse events affected 43 (27%) patients, leading to a cumulative incidence of 34% at 3 years. Infections were the most frequent adverse events (n = 13), followed by neurologic (n = 12), pulmonary (n = 6), or cardiovascular (n = 4). Eight malignancies were diagnosed (six solid, two hematologic), leading to a cumulative incidence of 3.7% at 3 years. Taking into account the competing risks, multivariate analysis revealed that the number of progressions (relative risk [RR] = 2.68) and a mitoxantrone‐containing conditioning regimen (RR = 2.98) significantly increased the incidence of late toxicity.

CONCLUSION

ASCT is effective in patients with aggressive NHL with a poor prognosis. However, careful long‐term follow‐up of survivors is recommended because of the increase in malignant and nonmalignant toxicities. Cancer 2005. © 2005 American Cancer Society.
Does maintenance/consolidation chemotherapy have a role in the management of small cell lung cancer (SCLC)?
Authors: Bozcuk Hakan , Artac Mehmet , Ozdogan Mustafa , Savas Burhan
Published: November 2005

BACKGROUND

The role of maintenance/consolidation chemotherapy was assessed in the management of small cell lung cancer (SCLC) via a metaanalytic approach.

METHODS

The Medline and Cochrane databases were searched for relevant randomized clinical trials that compared maintenance chemotherapy with follow‐up. Quality of trials was assessed by European Lung Cancer Working Party (ELCWP) score. Odds ratios and rate differences were used as the effect size. Mantel–Haenszel tests with fixed and random effect models were conducted for 1‐ and 2‐year overall survival (OAS) and progression‐free survival (PFS).

RESULTS

Fourteen relevant randomized clinical trials to date, encompassing 2550 patients, with trial sizes ranging from 36 to 610, were identified. Both 1‐ and 2‐year mortality were reduced with maintenance/consolidation chemotherapy. With the fixed model, odds ratios for 1‐ and 2‐year OAS were 0.67 (95% confidence interval [CI] = 0.56–0.79), P < 0.001, and also 0.67 (95% CI = 0.53–0.86), P < 0.001. Likewise, 1‐ and 2‐year PFS were better with maintenance/consolidation chemotherapy, with odds ratios of 0.49 (95% CI = 0.37–0.63), P < 0.001, and 0.64 (95% CI = 0.45–0.92), P < 0.015. The random model gave similar results. In accordance, maintenance chemotherapy improved 1‐ and 2‐year OAS by 9% (from 30–39%) and 4% (from 10–14%), respectively. Similarly, 1‐ and 2‐year PFS were also improved.

CONCLUSION

Maintenance/consolidation chemotherapy improves survival in SCLC. New randomized clinical trials are needed to further refine the place of this approach in the management of SCLC. Cancer 2005. © 2005 American Cancer Society.
Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas
Authors: Yamaguchi Taketo , Shirai Yoshihiko , Ishihara Takeshi , Sudo Kentarou , Nakagawa Akihiko , Ito Hiroshi , Miyazaki Masaru , Nomura Fumio , Saisho Hiromitsu
Published: November 2005

BACKGROUND

The examination of pancreatic juice cytology could hypothetically contribute to the establishment of a definite diagnosis of malignant intraductal papillary mucinous neoplasm of the pancreas (IPMN), but to the authors' knowledge, its significance has not been confirmed to date. The current study was conducted to assess the diagnostic value of pancreatic juice cytology in IPMN and to examine the usefulness of peroral pancreatoscopy (POPS) in sampling pancreatic juice.

METHODS

The study subjects were comprised of 103 patients with IPMN who underwent surgical resection of pancreatic tumors (adenoma in29 patients, borderline in17 patients, carcinoma in situ in 25 patients, and invasive carcinoma in 32 patients). Pancreatic juice was collected with a catheter in 71 patients and by POPS in 32 patients. Patients with pancreatic carcinoma (n = 81) and chronic pancreatitis (n = 76) also were investigated.

RESULTS

The cytologic diagnosis was found to be of nondiagnostic value in only one patient with an IPMN, whereas it was of no diagnostic value in 14 of the patients with pancreatic carcinoma (17.3%), a difference that was statically significant (P < 0.001). The location of the IPMN (either in the pancreas or the pancreatic ducts) was not found to significantly affect the diagnostic value of the test. The sensitivity for IPMN was 62.2% when pancreatic juice was collected by POPS, and was 38.2% when it was collected using a catheter. In the case of pancreatic carcinoma, the sensitivity of pancreatic juice cytology was found to be 25.4%, which was significantly lower than that for IPMN when the pancreatic juice was collected by POPS (P < 0.001).

CONCLUSIONS

Pancreatic juice cytology was found to have better diagnostic value in the patients with IPMNs compared with those with pancreatic carcinoma. POPS was found to be useful for the collection of pancreatic juice. Cancer 2005. © 2005 American Cancer Society.
To achieve (E)quality health care for childhood cancer survivors
Authors: Zebrack Brad J. , Chesler Mark A.
Published: November 2005

An expressed goal of psychosocial oncology research and intervention is to facilitate patients' and family members' adjustment to both the short‐term and long‐term consequences of treatment, recovery, and survivorship. Unfortunately, despite the growing attention to inequalities in health care, little is known regarding the ways in which socioeconomic, racial, and sociocultural status may affect the long‐term adjustment and functioning of ill children and their family members.
L‐asparaginase as a marker of chemotherapy dose modification in children with acute lymphoblastic leukemia
Authors: Baillargeon Jacques , Langevin Anne‐Marie , Lewis Margaret , Thomas Paul J. , Mullins Judith , Dugan John , Pollock Brad H.
Published: November 2005

BACKGROUND

The objective of the current study was to compare chemotherapy dose modifications in obese (a body mass index [BMI] > 95%) and nonobese (a BMI ≤ 95%) pediatric patients with acute lymphoblastic leukemia (ALL).

METHODS

The study cohort was comprised of 199 pediatric patients diagnosed with ALL who were treated at 1 of 2 South Texas pediatric oncology centers between 1990–2000. The relative chemotherapy dose modification during the induction phase of chemotherapy was calculated as the ratio of 1) the actual administered dose of L‐asparaginase and 2) the protocol‐calculated dose of L‐asparaginase. The extent to which the chemotherapy dose modification varied according to obesity status was assessed using stratified Student t tests and an ordinary least‐squares regression analysis.

RESULTS

Obese ALL patients were found to exhibit a 7% decrease in the mean relative modification of L‐asparaginase during induction chemotherapy compared with their nonobese counterparts. This finding was statistically significant (P = 0.009), even after adjustment for gender, age, ethnicity, and clinical institution.

CONCLUSIONS

To the authors' knowledge, the current study is the first published report of an obesity‐associated chemotherapy dose modification in pediatric patients with ALL, the most common childhood malignancy. It will be important to examine whether these findings are consistent with those observed in future studies, and ultimately to assess the association between obesity‐related dose modifications and long‐term cancer outcomes. Cancer 2005. © 2005 American Cancer Society.
Performance analysis of high‐performance file‐transfer systems for Grid applications
Authors: Anglano Cosimo , Canonico Massimo
Published: November 2005

Data‐intensive Grid applications require the availability of tools able to transfer very large files in the shortest amount of time. Many file‐transfer tools, based on solutions aimed at overcoming the limitations imposed by the TCP protocol, have recently been developed. In this paper we experimentally compare the performance of some of these tools in various network scenarios by running experiments on PlanetLab, an open platform for the development, deployment, and access of planetary‐scale services, that comprises hundreds of hosts scattered across the globe. Our results show that solutions based on UDP and adopting rate‐based algorithms result in better performance than other alternatives in most cases, while solutions based on TCP achieve similar performance only under specific circumstances. Copyright © 2005 John Wiley & Sons, Ltd.