bluuebunny/crossref_metadata_2025 huggingface dataset:
Význam kultúrnej kompetencie v príprave budúcich prekladateľov a tlmočníkov
Authors: Koželová Adriána Ingrid
Published: January 2023

Cieľom štúdie je poukázať na význam kultúrnej kompetencie v študijných programoch zameraných na prípravu budúcich prekladateľov a tlmočníkov. Súčasťou štúdia týchto odborov je aj tzv. spoločný základ, ktorý poskytuje vzdelanie v oblastiach, ktoré sú spoločné pre všetky jazykové kombinácie. V prvom rade sú to všeobecné teoretické translatologické disciplíny, ale aj také, ktoré sú špecifické. K takýmto predmetom patrí aj disciplína Klasické jazyky a tradície. Ide o prehľadovú disciplínu, ktorá významným spôsobom prispieva k budovaniu kultúrnej kompetencie prekladateľa. Štúdia poukazuje na vstupné dáta na začiatku semestra a finálne údaje, ktoré mapujú úspešnosť zvládnutia predmetu a  význam jeho absolvovanie  pre prekladateľa a tlmočníka.
Study of AI and ML Based Technologies used in International Space Station
Authors: Piyush Pant  , Anand Singh Rajawat
Published: January 2023

There are billions of galaxies, stars, solar systems, planets, and other undiscovered mysterious objects in expanding space. Humans took a giant step forward in exploring such a three-dimensional dark box when the International Space Station was deployed into Earth's lower orbit for study and to better understand the environment of space. Previous publications have discussed how artificial intelligence is being utilized to explore space and identify habitable worlds. This paper describes some of the AI-based technologies that are employed in the International Space Station, which is a key component of future space exploration. The study also looks at AI technologies that might be deployed on the International Space Station to increase its efficiency and provide security to the crew. The study includes a full explanation of the requirement, operation, and construction of NASA's "Robonauts" designed for the International Space Station. The paper also mentions ATLAS, an asteroid detecting system. The methods for providing medical aid to the crew, debris and its influence, analyzing data and extracting insight from space research data using machine learning are also highlighted. This study investigates how technology used in space exploration could be used to the ISS to improve its performance and provides an overview of some of the existing AI-based technologies utilized in the International Space Station (ISS).
PHYTOPHARMACETICAL AND ANTICANCER PROPERTIES OF NIGELLA SATIVA LINN SEEDS: A COMPREHENSIVE REVIEW
Authors: Saptarshi Samajdar
Published: January 2023

Cancer is a growing health problem around the world and is second leading cause of death after heart disease. Although in the last century there has been effort to control the disease using various synthetic as well as herbal drugs but still not been controlled satisfactorily. Nigella sativa is one such herb which has very high potential in preventing cancer. There are various categories of phytochemicals that have been isolated from the plant and mainly terpene category of phytochemicals in the likes of Thymoquinone, carvone, germacrene, sabinene, alphahederin are prevalent. Some other phytochemicals that has been isolated are nigellone, nigellidone (alkaloids) cycloartenol, tirucallol, some fatty acids as well. Mainly two compounds have been concentrated upon for cancer, they are thymoquinone and alpha hederin N. sativa has been known to shown high efficacy in cancer and mainly works by promoting Caspase 8,9,3, suppressing Akt and NF-kB. Even some semisynthetic derivative like poloxin, kalapanaxosaponin I and also combination therapy has been found to be effective against cancer.
A Thomistic Reading of Alypius’ Curiositas in Augustine’s Confessiones (6, 8, 13)
Authors: Rehman Rashad ,   Instituto Patristico Augustinianum
Published: January 2023

What is Augustine’s commentary on Alypius’ curiosity (curiositas) at the gladiatorial show in Confessiones 6, 8, 13 fundamentally about? Augustinian scholars have interpreted the story widely. Following recent scholarly developments, this work argues for a distinctively Thomistic reading of Alypius’ curiositas. In 1987, Joseph Torchia interpreted this passage as putting only a secondary focus on the story’s emphasis on, in his words, «conflict with God, its inner self, and others». However, this triadic conflict is found in Aquinas: in his Commentary on the Gospel of John (14, 7), Aquinas argues that a conflict with God, self and others is what it means to lack peace (pax). Confessions 6, 8, 13 is read here through a Thomistic lens: the presentation of Alypius’ curiositas is fundamentally a statement about Alypius’ lack of peace.
Ill-Being for Subjectivists
Authors: Dorsey Dale ,   Philosophy Documentation Center
Published: January 2023

The axiological phenomenon of ill-being has been thought to be a special problem for subjectivist theories. I argue here that this common supposition is false. I argue that no leading theory of subjectivism need be unable to accommodate the phenomenon of ill-being. In addition, subjectivists on the whole are licensed to adopt somewhat more outré alternatives, including adopting a disunified approach to ill-being, or rejecting the notion altogether.
The Hydrographer of the Future - Reflections on an international virtual workshop
Authors: Foroutan Mina , Bhatia Sonja , Béchard Geneviève
Published: January 2023

The Canadian Hydrographic Service (CHS) expects the skillsets of its multidisciplinary hydrographers to evolve as the field of hydrography undergoes a digital transformation. To characterize these changes, the CHS organized a virtual workshop titled Hydrographer of the Future, in which it heard the perspectives of international colleagues in other Hydrographic offices (HO’s), industry, and academia. Despite some variations, common themes emerged: the changing technological context, people and culture, and the future role of hydrography. The results of this workshop support the CHS’ own internal planning; however, the CHS also hopes to continue learning from its international partners and share its experiences through the International Hydrographic Organization’s (IHO) e-learning center.
EFFECT OF MAGNESIUM TREATMENT PROCESS ON THE PRODUCING COMPACTED GRAPHITE CAST IRON WITH DIFFERENT CASTING THICKNESS
Authors: Purwadi Wiwik , Ramadhani Tama , Polonia Betti Ses Eka , Yusuf Yusuf
Published: January 2023

Strength, toughness, machinability and damping capacity are properties of compacted graphite iron that distinguish the properties between flake graphite cast iron and spheroidal cast iron. The formation of compacted graphite can be set to achieve the required specification. The formation of compacted graphite is started from spheroidal to compacted cast iron. The residual magnesium after magnesium treatment and the solidification rate have a significant role in the formation of compacted graphite. The high content of residual magnesium can obstruct the graphite plane to grow during the transformation from spheroidal to compacted shape. In addition, the cooling rate of the casting can be controlled by varying the casting thickness. The compacted graphite in the cast iron are characterized according to shape, size and distribution. The optimum compacted graphite in the cast iron that can be produced has 30 mm of casting thickness with 0.017 % of residual magnesium.
PENGARUH KOMPOSISI SERAT KENAF DAN SERBUK CACO3 TERHADAP KEKUATAN TEKUK DAN WATER ABSORPTION KOMPOSIT HYBRID-POLIESTER
Authors: Laksana Alfian Hudan , Waluyo Marhadi Budi
Published: January 2023

Komposisi penguat dalam material komposit hybrid dapat mempengaruh sifat materialnya. Serat kenaf (Hibiscus Cannabinus L.) dapat menjadi penguat komposit hybrid dengan potensi manfaat yang tinggi. Kalsium karbonat berfungsikan sebagai penguat material komposit dan bermanfaat untuk meningkatkan kekakuan. Tujuan penelitian ini adalah menganalisis pengaruh variasi komposisi penambahan serat kenaf dan serbuk CaCO3 terhadap kekuatan tekuk dan sifat daya serap air komposit hybrid poliester tak jenuh/serat kenaf/CaCO3 (PTJ/SK/CaCO3) yang dibuat dengan metode hand layup. Komposit hybrid dibuat dengan variasi komposisi CaCO3 (0%, 2,5%, 5%, 10%, dan 20% berat). Hasil penelitian menunjukkan komposit hybrid PTJ/SK/CaCO3 (5%wt) memiliki kekuatan tekuk tertinggi dengan nilai 74,87 MPa. Peningkatan jumlah komposisi serbuk CaCO3 menunjukkan hasil daya serap air yang menurun pada komposit hybrid PTJ/SK/CaCO3.
IMPLEMENTASI LOAD BALANCING METODE PER CONNECTION CLASSIFIER DAN FAILOVER RECURSIVE MENGGUNAKAN MIKROTIK
Authors: Rahmat Bilal Magfa Ribhi
Published: January 2023

With the rapid development of technology, a company or agency must adapt systems that are evolving fast day by day. At PT Global Teknologi servisindo have problems faced with several problems due to complaints from employees who are constrained by a slow internet connection. Inadequate facilities such as devices to manage all internet connection systems and providers who are not yet able to accommodate the burden of internet lines. The implementation of load balancing with pcc and recursive failover methods enables internet connection and optimizes internet paths effectively. The device used is the Mikrotik RB1100ahx and to configure the load balancing and failover system using the Winbox software. The use of load balancing and failover can reduce internet paths so that there is no overload on the internet network. The results obtained by building a load balancing and failover system that maximizes internet connections properly and reduces overloads on internet lines, this proves that load balancing and failover are running well according to the configuration made.
Ajaran Tasawuf dan Tokoh-Tokohnya
Authors: Ilham  , Muhammad Amri  , Indo Santalia
Published: January 2023

Sufism is part of the Islamic syari'at whose teachings are more focused on purification of the soul in order to achieve closeness, love, and unity with Allah as its creator. Historically Sufism can be divided into several periods, namely the formation period, the development period, the consolidation period, the philosophical period, and the purification period. From these several periods it can be seen that there were two streams in Sufism, namely semi-falsafi Sufism which later became philosophical Sufism and Sunni Sufism. These two streams then colored the world of Sufism. Sunni Sufism is categorized as conscious Sufism, in which the understanding of Sufism is explained simply, so that it can be understood and understood by all groups. The teachings in Sunni Sufism are more directed towards behavior that is in accordance with the Qur'an and the Sunnah of the Prophet Muhammad, so that to become a Sufi candidate one must understand the Shari'ah very well. Meanwhile, philosophical Sufism bases its teachings more on reason and feeling (dzauq), but that does not mean abandoning Shari'at, these two schools of Sufism (Sunni and Falsafi) both prioritize Shari'at, it's just that the understanding of Sufism in Falsafi flow is rather complicated to be understood by humans in general, because the expressions used are vague (syathahiyyat) and contain symbolic elements, their Sufis also experience ecstasy (spiritual intoxication).
Zote 'tonto': una nueva propuesta etimológica
Authors: Georgescu Simona
Published: January 2023

El esp. zote se cataloga en el DCECH como “voz de creación expresiva”, etiqueta criticada por David Pharies (1984). Nos proponemos retomar el asunto, ampliando la perspectiva con un análisis detallado de las voces que se pueden identificar como cognados de la palabra que nos ocupa. En primer lugar, emprendemos un examen semántico de los vocablos para mostrar que las aparentes divergencias de significado responden fielmente a una red conceptual recurrente, cuyo núcleo expresa un ‘ímpetu’, verbalizado por una onomatopeya. Tras identificar los lazos conceptuales entre las palabras originadas en esta onomatopeya, se explica la variación fonética y, por el intermedio del método gramática comparada – reconstrucción, se establece el étimo protorrománico de la familia. Esta investigación confirma, de hecho, la validez de la etiqueta de “creación expresiva” que proponían Corominas y Pascual para zote y sus cognados.
Thomas Jefferson : vers une démocratie de petits propriétaires fonciers indépendants et instruits. Le township and range system, projection territoriale d’un projet de société / Thomas Jefferson: towards a democracy of independent and educated small landowners. The township and range system, territorial projection of a social project
Authors: Charvet Jean-Paul
Published: January 2023

This academic paper presents the spatial model that was built at the end of the 18th century and used for cuting up the major parts of the US rural spaces. It comes from the Jefferson’s vision for an agrarian society founded on a democracy based on small, independent and well educated land owners.
A non-systematic, descriptive literature review of observational research on anxiety during the first COVID-19 pandemic phase
Authors: Cavieres Álvaro , Arancibia Marcelo
Published: January 2023

Fear of contagion, together with the consequences of mitigation strategies, are often cited as causes of high levels of anxiety in the general population in the context of the COVID-19 pandemic. However, it is unclear whether published reports make it possible to distinguish between normal and pathological anxiety. We conducted a non-systematic, descriptive literature review on observational studies reporting the prevalence or frequency of anxiety symptoms in non-clinical settings published between July and December 2020. Seventy-six studies were included. Two were conducted through telephone contact while the remainder were conducted on the internet. Factors associated with greater presence/severity of anxiety symptoms were sociodemographic variables (e.g., age, gender, employment, place of residence, living conditions, marital status, and educational level). Thirty publications (39.4%) reported data on a comparison group, including samples of general populations from different geographic regions or in different periods. Only 16 studies (21%) included some estimation of the functional impairment of detected anxiety symptoms. Only seven of the studies that estimated functional impairment had comparison groups. None of the studies included in this review contain sufficient contextual or descriptive information to determine whether the reported high levels of anxiety are normal reactions of subjects in high-stress situations or actual psychiatric disorders.
Nuevas perspectivas sobre la colonización cisterciense en el noroeste peninsular: la renovadora gestión del Abad Gómez Pérez (1230-1262) y su huella
Authors: ÁLVAREZ CASTRILLÓN José Antonio
Published: January 2023

The Asturian monastery of Villanueva de Oscos, bordering Galicia, is a good example of the Cistercian colonization that shaped the traditional agrarian landscape of northwestern Spain. Articulated around the figure and determining mandate of Abbot Gómez Pérez, in the second third of the 13th century, this work analyses the intense task it faced, and seeks to assess both the originality of its solutions and the continuity of its approaches in the subsequent monastic administration. The method used, in the light of the reference bibliography, comparing his period with the previous tradition and the customs of other institutions: Belmonte, Meira, Carracedo, Oseira and Moreruela.

El monasterio asturiano de Villanueva de Oscos, limitáneo con Galicia, constituye un buen ejemplo de la colonización cisterciense que conformó el paisaje agrario tradicional del noroeste peninsular. Articulado en torno a la figura y el mandato determinante del abad Gómez Pérez, en el segundo tercio del siglo XIII, este trabajo analiza la intensa tarea que afronta, y pretende valorar tanto la originalidad de sus soluciones como la continuidad de sus planteamientos en la administración monástica posterior. El método empleado, a la luz de la bibliografía de referencia, compara su periodo con la tradición anterior y los usos de otros monasterios: el asturiano de Belmonte, los gallegos de Meira y Oseira, el leonés de Carracedo, y el zamorano de Moreruela.
baja nobleza y las luchas de bandos de la ciudad de Valencia (1380-1412)
Authors: GALÁN CAMPOS Luis
Published: January 2023

Lesser nobility in the Kingdom of Valencia in the Late Middle Ages is a topic that offer vast possibilities to research, which would enable us to recognize better the political evolution and relations of power in the aforesaid kingdom during the 14th and 15th centuries. Therefore, in this paper we’ll try to examinate the origins and familiar composition of the city of Valencia lesser nobility at the end of the 14th century and to understand the problematics of feud and elite unrest in this period through questions such as the wealth management and kinship or affinity relationships.

La baja nobleza del reino de Valencia durante la baja edad media es un tema que ofrece grandes posibilidades para la investigación, lo que nos permitiría comprender mejor la evolución política y las relaciones de poder en el dicho reino durante los siglos XIV y XV. Por ello, en este artículo trataremos de analizar el origen y la composición familiar de la baja nobleza de la ciudad de Valencia a finales del siglo XIV y entender la problemática de los bandos y la conflictividad de las élites en este periodo a través de cuestiones como la gestión del patrimonio y las relaciones familiares o de afinidad.
Colaboracionismo y resistencia bajo los gobiernos de los primeros condes de Ureña
Authors: MARTÍN HUMANES José María
Published: January 2023

The Giron clan was as voracious in high Castilian politics as they were in the administration of their manors. The number of lawsuits that their vassals filed against them shows that the government of their territories was anything but peaceful. Their measures in Morón de la Frontera, one of their most prominent villages, offer some of the keys to how the Osunas understood the seigniorial regime and how they put it into practice. In fact, their policies had a strong impact on the local space. The following study aims to take a look at the rural world of Seville and dive into the power struggles unleashed in Morón de la Frontera as a result of the actions of the first counts of Ureña.

Los Girones fueron tan voraces en la alta política castellana como en la administración de sus señoríos. La cantidad de pleitos que libraron contra sus vasallos constata que el gobierno de sus estados fue cualquier cosa menos pacífica. Su actuación en Morón de la Frontera, una de sus villas más destacadas, ofrece algunas de las claves en torno a cómo los Osuna entendieron el régimen señorial y cómo lo llevaron a la práctica. De hecho, sus políticas tuvieron un fuerte impacto en el espacio local. El estudio que presentamos a continuación tiene por objeto volver la mirada al mundo rural sevillano y sumergirnos en las luchas de poder desatadas en Morón de la Frontera como consecuencia de la gobernanza de los primeros condes de Ureña.
Effect of alternate nostril breathing on evoked potentials among internet addicts
Authors:   Department of Physiology, Sri Venkateshwaraa Medical College Hospital and Research Center, Ariyur, Pondicherry, Udayakumar Karthika Priyadharshini
Published: January 2023

Increased availability of smartphones and easy access to the internet among adolescents has resulted in Internet Addiction (IA). Effects of IA and Pranayama on evoked potential are available but studies on the comparison of immediate and 6-week effects of alternate nostril breathing on evoked potentials among medicos with internet addiction are not available as per our search in PubMed, hence the study was chosen. In this comparative study 100 male and female medical students aged between 18-25 years, with internet addiction scores≥50 were included as study participants. P300 auditory event-related potential and pattern reversal visual evoked potential (VEP) were recorded before, immediately, and 6 weeks after practicing pranayama. Repeated measure ANOVA shows statistically significant change (P< 0.05) in P300 amplitude, P100 latency, N145 latency, and VEP amplitude. The post hoc Bonferroni test shows that P100 latency and N145 latency significantly reduced immediately after 15 minutes of pranayama. P300 amplitude and VEP amplitude significantly increased only after practicing pranayama for 6 weeks. Pranayama has an immediate effect on latency, but it takes 6 weeks of practice to significantly change amplitude.
Severity in schizophrenia patients receiving atypical antipsychotic medications
Authors:   Department of Pharmacology, KD Medical College, Hospital & Research Center, Mathura, India, Alam Fatmi yed Meraj
Published: January 2023

Atypical antipsychotic drugs are nowadays the mainstay of treatment of schizophrenia due to their lesser extrapyramidal symptoms (EPS) as adverse effects. However, these drugs have different profiles of adverse drug reactions (ADRs). Here, the objective of this study was to analyze the probability, occurrences, and more significant involvement of various risk factors. A prospective observational study was carried out on a patient with schizophrenia who has prescribed atypical antipsychotic drugs for their treatment. The probability of the ADR was analyzed by using the Naranjo causality assessment scale. While Glasgow antipsychotic Side effect Scale (GASS) was used to estimate the severity of side effects. Statistical software for social science (SPSS) ver 25; was used for different descriptive statistics and chi-square analysis. A total of 140 patients were included in the study of which the majority (58.57 %) was male. However, atypical antipsychotic drugs were primarily prescribed to the patient as mono therapy (81.43 %). Interestingly, COVID-19 infections were reported as positive in 39.29 % of total patients. Probability assessment of ADRs revealed that most (55 %) were “Probable”. Subsequently, the GASS score was evaluated for severity, the majority (55.71 %) were reported as “Mild”. The statistically significant association between gender and severity of side effects &duration of illness and severity of side effects were found (P>0.5).The Present study aids in knowing the risk factors and improving the management practices of ADR, thereby improving the guidelines in terms of safe clinical approaches for psychiatric patients.
Analysis of microbiome diversity in coprolites from Caral, Peru
Authors:   ALBIOTEC, Lima, Perú, Jaramillo-Valverde Luis
Published: January 2023

We analysed human coprolites from the Sacred City of Caral, the oldest civilization in America (3000- and 1800-years BC). Our objective was to know the microbial diversity of the Caral Civilization through the use of a mobile ancient laboratory. DNA extraction was conducted in a mobile laboratory placed near the collection site to reduce exposure of samples to contaminants and favor a rapid molecular processing. Using 16S rRNA and ITS 1 amplicon sequencing, we have elaborated the first list of the microbiomes of Caral, based on the bacterial and fungal community fingerprints detected in the coprolites recovered in six sectors of that ancient urban center. Among the most abundant sequences were those associated with Firmicutes for bacteria, Ascomycota and Basidiomycota for fungi. Bacillus was the most abundant bacterial genera in all samples analyzed, compromising up to 24.81% of the total bacterial abundance; while Aspergillus (11.43%) was the most abundant genera among fungal communities.
Piezo-surgery in periodontics
Authors:   Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600077, Chatterjee Shubhangini
Published: January 2023

Periodontitis is a chronic inflammatory disease of the tooth-supporting structures. The treatment of this condition is primarily based on the removal of local factors and the restoration of the bony architecture. Furthermore, in the modern era of dentistry, successful implant therapy frequently necessitates strong osseous support. Traditionally, osseous surgery has been performed using either manual or motor-driven instruments. Both methods, however, have advantages and disadvantages. A novel surgical approach utilising a piezoelectric device has recently been introduced in the field of periodontology and oral implantology. This narrative review article discusses the numerous applications of this novel technique of piezosurgery in periodontology.
Apperception and Object —Comments on Mario Caimi’s Reading of the B-Deduction
Authors: Schulting Dennis
Published: January 2023

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Acerca de la Deducción de las categorías en la primera edición de la Crítica de la razón pura
Authors: Baum Manfred
Published: January 2023

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Aproximació als recursos documentals catalans per a l’estudi de l’exili del 1939
Authors: Arañó Vega Laia , Doll-Petit Rubèn , Montblanc Joan Lasaga
Published: January 2023

Aquest article pretén ser una eina útil per als especialistes i per a les persones en general que tinguin la voluntat d’aprofundir en l’estudi de l’exili del 1939. Amb una mirada crítica en el context històric europeu del moment, sense el qual la diàspora del 1939 perd qualsevol sentit, en aquest article us detallem els fons documentals de l’exili que es localitzen a Catalunya i, més concretament, la documentació que es troba en molts dels arxius municipals del nostre país i que descriu els recorreguts vitals de tots i cadascun dels protagonistes d’aquesta diàspora.
La recomposició del panorama educatiu francòfon de Barcelona (1965-1972)
Authors: Horn Guillaume
Published: January 2023

L'oferta educativa francòfona a Barcelona va tenir un punt d'inflexió als anys 60: a l'institut francès, l'arribada d'un nou director, amb el projecte d'afrancesar-lo, va provocar divergències. L'any 1968, part de la plantilla i els estudiants el van deixar per fundar Aula, ratllant-ne definitivament la imatge. Les diferències van aparèixer al seu torn en aquesta nova escola, que un professor va deixar per fundar l'escola Bon Soleil l'any 1969. Aquestes successions de desacords van contribuir a reforçar la influència francesa, amb un augment considerable del nombre d'estudiants que estudien en francès o segons el mètode francès a partir dels anys setanta.
Recuperació, dignificació i patrimonialització. Espais de memòria de l'exili republicà a Catalunya i Occitània
Authors: Serrano Jiménez Miquel , Gaitx Moltó Jordi
Published: January 2023

Després d’introduir i contextualitzar la història de la creació i institucionalització dels diferents espais de memòria a Catalunya (Espanya) i a Occitània (França), en aquest article descrivim i analitzem el contingut del «Repositori d’exili (1936–1945). Cercador de la Retirada i dels camps de concentració del sud de França», elaborat per al projecte «Memòria i patrimoni de l’exili a l’Euroregió Pirineus Mediterrània (1936–1945)». Des de finals del segle xx, la tasca de determinades entitats memorialistes de la societat civil, impulsada per les lleis de memòria aprovades el 2007, ha permès posar en valor els projectes de senyalització existents, així com avançar substancialment en la instal·lació de textos explicatius en nous espais. Gràcies a tots aquests esforços, el repositori ha pogut recollir 359 espais de memòria de Catalunya i Occitània vinculats a l’exili republicà.
Jelin, Elisabeth, i Ricard Vinyes. 2021. Cómo será el pasado. Una conversación sobre el giro memorial. Barcelona: Ned Ediciones. 124 p.
Authors: Font Agulló Jordi
Published: January 2023

Aquest text és la ressenya crítica del llibre de la sociòloga argentina, Elisabeth Jelin, i l'historiador català, Ricard Vinyes. En el text es ressegueix la conversa establerta entre els dos autors entorn de qüestions com les polítiques de memòria, les patrimonialitzacions de les memòries, les relacions entre història i memòria, la memòria i la presència a l'espai públic, entre altres.
Topical steroid menace: A case series of severe debilitating infections during the COVID-19 pandemic
Authors:   Department of Dermatology, M S Ramaiah Medical College and Hospital, Bengaluru, India, Patil Deena , Shivaswam Kanakapura Nanjundaswam , Reddy Namitha Subramani , Sumathy Tharayil Kunnet
Published: January 2023

ABSTRACT Background: Topical corticosteroids is a boon and also a bane in treating chronic skin conditions. The risk of cutaneous infections due to topical steroids increases with their potency, dose, and duration of treatment. Herein, we present a case series of severe debilitating infections secondary to topical steroid abuse. Materials and Methods: We came across five cases of severe skin infection following the prolonged application of topical steroids. These cases gave a history of the use of steroid creams for persistent skin conditions and the inability to visit the hospital due to the prevailing COVID-19 pandemic. Observations: We came across two cases of crusted scabies, two cases of Fournier’s gangrene, and a case of erosio interdigitalis blastomycetica. These cases had been using topical steroids for a prolonged period for other dermatological conditions. Conclusion: We propose that, as crusted scabies and erosio interdigitalis blastomycetica mimic various other papulosquamous disorders, a KOH examination is a diagnostic tool. Topical steroid abuse is one of the predisposing factors for Fournier’s gangrene. Key words: Topical Steroids; Crusted Scabies; Fournier’s Gangrene; COVID-19
Pigmented eccrine poroma in collision with seborrheic keratosis: Dermoscopic description and histological correlation
Authors:   Department of Dermatology, University Hospital Hassan II, Fes, Morocco, 2Hassan Anatomical Pathology Center – Rabat, Morocco, Dassouli Ryme , Douhi Zakia , Joutei Kenza Tahiri , BayBay Hanane , Elloudi Sara , Rimani Mouna , Mernissi Fatima Zahra
Published: January 2023

Poromas are rare, benign neoplasms arising from the terminal ductal portion of the sweat glands. They are mainly characterized by flesh-colored or pink papules or nodules, usually located at the extremities. The pigmented variant is rare. Collisions with other benign epithelial tumors have been reported. The clinical appearance may be confused with several benign or malignant tumor pathologies, yet thanks to dermoscopy, which is a non-invasive means of exploration, some signs are highly useful in the diagnosis and in suspecting the collision of two distinct tumors before proceeding to histological confirmation. Herein, we report the original case of a collision between pigmented eccrine poroma of the leg and seborrheic keratosis. Key words: Pigmented poroma; Collision; Dermoscopy; Histology; Seborrheic keratosis
Cutaneous manifestations associated with COVID-19 in 24 cases from Fez, Morocco
Authors:   Department of Dermatology, University Hospital Hassan II Fès, Morocco, Chhiti Sokaina , Baybay Hanane , Hashas Fatima Zahra , Douhi Zakia , Elloudi Sara , Mernissi Fatima Zahra
Published: January 2023

Various cutaneous manifestations occurring during SARS- CoV-2 infection have been reported since March 2020. Their exact incidence remains to be estimated, their pathophysiological mechanisms are largely unknown, and the role of SARS-CoV-2 in their pathogenesis—direct or indirect—is still being debated. This was a prospective study conducted since the beginning of the pandemic including 24 patients with cutaneous manifestations associated with COVID-19.
Rapidly fatal metastatic melanoma arising from a congenital nevus in a young female
Authors:   Department of Dermatology, University Hospital Hassan II, Fes, Morocco, Kassel Jihad ,   Radiation oncology department, Oncology hospital, University Hospital Hassan II, Fes, Morocco, Elloudi Sara , Soussy Kaoutar , Chhiti Soukaina , Baybay Hanane , Douhi Zakia , Bouhafa Touria , Mernissi Fatima-Zahra
Published: January 2023

Melanoma is an aggressive and potentially fatal tumor of melanocytic origin. It may occur at any age yet more rarely at a young age. Melanomas in young patients have overall a more favorable prognosis than in older. However, progression to the metastatic stage and the death of the patient are not exceptional. One of the major risk factors for the development of melanoma in children and young adults is the congenital melanocytic nevus (CMN) [3]. The risk of malignant transformation of all congenital nevi ranges from 0.05% to 10.7%. The risk of malignant degeneration is correlated with size and location [4]. The size of the CMN above 40 cm as well as the presence of satellite nevi and the location in the trunk seem to increase the risk of developing MM. The role of surgical removal in inducing melanomas is controversial. In anatomopathology, melanomas arising from CMNs are usually located in the dermis and hypodermis, while melanocytic proliferation in a melanoma without a CMN starts in the epidermis [3]. Given the differences in the anatomical involvement of the disease, melanoma arising from congenital nevi may be considered a separate entity from the conventional case of melanoma and management may differ. Large excision may not be sufficient to remove all neoplastic cells from the nevi, and adjuvant aggressive systemic therapies may be essential to avoid a fatal outcome. A recent study revealed that congenital nevi preferentially harbor NRAS mutations rather than BRAF mutations commonly seen in other types of nevi, indicating an altered molecular basis of nevogenesis in congenital nevi. Herein, we report the case of a rapidly fatal metastatic melanoma in a young female arising from a congenital nevus of the trunk.
Examining Retro Merchandise Consumers in Sport: Who Prefers Throwback Merchandise and Why?
Authors: Scola Zach , Gordon Brian , Dwyer Brendan
Published: January 2023

Retro marketing in sport has been relied upon for years. Sport fans see more teams and leagues implement retro marketing and merchandise into marketing plans. Despite this, we have little understanding behind the success of retro marketing in sport. Therefore, this paper sought to gain a better understanding of the demographic characteristics of retro merchandise consumers and to examine the impact of two psychographic factors. Surveys collected from fans of various professional sport teams in the United States (N = 1,509), demonstrated novel findings. In this study retro merchandise was preferred overall, younger fans were more likely to prefer retro merchandise, and household income did not explain much of the preference. Most telling was that nostalgic proneness significantly and positively predicted a retro preference. The implications from this study should guide marketers in their usage of retro merchandise and marketing practices and lead to future practical research on the topic.
Parent artery occlusion of a giant internal carotid artery pseudoaneurysm-related direct carotid cavernous fistula: A case report
Authors: Andreev Alexander , McMillan Nadia , Money Kelli , Shutran Max , Ogilvy Christopher
Published: January 2023

Traumatic internal carotid artery injuries can produce direct carotid-cavernous fistulas as well as giant internal carotid artery pseudoaneurysms. Clinical sequelae can include headaches, cranial nerves palsies, proptosis, chemosis and optic neuropathy with visual loss as the most dangerous complication. Herein, we present a case of one of the largest reported internal carotid artery pseudoaneurysms associated with a direct carotid cavernous fistula. We describe the techniques and pitfalls of treatment with parent vessel occlusion.
Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine
Authors: Cheung Foo , Apps Richard , Dropulic Lesia , Kotliarov Yuri , Chen Jinguo , Jordan Tristan , Langweiler Marc , Candia Julian , Biancotto Angelique , Han Kyu Lee , Rachmaninoff Nicholas , Pietz Harlan , Wang Kening , Tsang John S , Cohen Jeffrey I
Published: January 2023

Background:

Both sex and prior exposure to pathogens are known to influence responses to immune challenges, but their combined effects are not well established in humans, particularly in early innate responses critical for shaping subsequent outcomes.

Methods:

We employed systems immunology approaches to study responses to a replication-defective, herpes simplex virus (HSV) 2 vaccine in men and women either naive or previously exposed to HSV.

Results:

Blood transcriptomic and cell population profiling showed substantial changes on day 1 after vaccination, but the responses depended on sex and whether the vaccinee was naive or previously exposed to HSV. The magnitude of early transcriptional responses was greatest in HSV naive women where type I interferon (IFN) signatures were prominent and associated negatively with vaccine-induced neutralizing antibody titers, suggesting that a strong early antiviral response reduced the uptake of this replication-defective virus vaccine. While HSV seronegative vaccine recipients had upregulation of gene sets in type I IFN (IFN-α/β) responses, HSV2 seropositive vaccine recipients tended to have responses focused more on type II IFN (IFN-γ) genes.

Conclusions:

These results together show that prior exposure and sex interact to shape early innate responses that then impact subsequent adaptive immune phenotypes.

Funding:

Intramural Research Program of the NIH, the National Institute of Allergy and Infectious Diseases, and other institutes supporting the Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation. The vaccine trial was supported through a clinical trial agreement between the National Institute of Allergy and Infectious Diseases and Sanofi Pasteur. Clinical trial number: NCT01915212.
DIAMAS
Authors: Mounier Pierre , Aspaas Per Pippin
Published: January 2023

In this episode, we are discussing the project Developing Institutional Open Access Publishing Models to Advance Scholarly Communication, in short: DIAMAS. At the heart of the project is support for Diamond Open Access, i.e. free for the reader as well as the author (no publishing charges). Co-lead of DIAMAS, Pierre Mounier explains the importance of lending support to not-for-profit institutional publishing. Besides the diversity offered by such scholar-led, high quality publication outlets, the multilingualism that they represent is key when the dissemination of knowledge and the promotion of citizen science across Europe is taken into account. The Helsinki Initiative on Multilingualism in Scholarly Publishing lends verbal support to linguistically diverse scholarly outputs; the EU-funded DIAMAS Project paves the way for stronger and more sustainable infrastructures facilitating them.
Since its inception in September 2022, the project will last for 3 years. An ultimate goal of DIAMAS is to help the providers of publishing services raise the quality and visibility of diamond open access by establishing a Europe-wide capacity center. A sister project, CRAFT-OA, focusing on the purely technical aspects of institutional diamond open access publishing begins in January 2023. The preliminary Diamond OA Journals Study (published March 2021), the first ever global survey of diamond open access journals, serves as foundation for both projects.
The recording was made in conjunction with the Munin Conference on Scholarly Publishing in December 2022. First published online January 10, 2023.
Flexor hallucis brevis motor unit behavior in response to moderate increases in rate of force development
Authors: Aeles Jeroen , Kelly Luke A. , Cresswell Andrew G.
Published: January 2023

Background

Studies on motor unit behaviour with varying rates of force development have focussed predominantly on comparisons between slow and ballistic (i.e., very fast) contractions. It remains unclear how motor units respond to less extreme changes in rates of force development. Here, we studied a small intrinsic foot muscle, flexor hallucis brevis (FHB) where the aim was to compare motor unit discharge rates and recruitment thresholds at two rates of force development. We specifically chose to investigate relatively slow to moderate rates of force development, not ballistic, as the chosen rates are more akin to those that presumably occur during daily activity.

Methods

We decomposed electromyographic signals to identify motor unit action potentials obtained from indwelling fine-wire electrodes in FHB, from ten male participants. Participants performed isometric ramp-and-hold contractions from relaxed to 50% of a maximal voluntary contraction. This was done for two rates of force development; one with the ramp performed over 5 s (slow condition) and one over 2.5 s (fast condition). Recruitment thresholds and discharge rates were calculated over the ascending limb of the ramp and compared between the two ramp conditions for matched motor units. A repeated measures nested linear mixed model was used to compare these parameters statistically. A linear repeated measures correlation was used to assess any relationship between changes in recruitment threshold and mean discharge rate between the two conditions.

Results

A significant increase in the initial discharge rate (i.e., at recruitment) in the fast (mean: 8.6 ±  2.4 Hz) compared to the slow (mean: 7.8 ± 2.3 Hz) condition (P = 0.027), with no changes in recruitment threshold (P = 0.588), mean discharge rate (P = 0.549) or final discharge rate (P = 0.763) was observed. However, we found substantial variability in motor unit responses within and between conditions. A small but significant negative correlation (R2 = 0.33, P = 0.003) was found between the difference in recruitment threshold and the difference in mean discharge rate between the two conditions.

Conclusion

These findings suggest that as force increases for contractions with slower force development, increasing the initial discharge rate of recruited motor units produces the increase in rate of force development, without a change in their recruitment thresholds, mean or final discharge rate. However, an important finding was that for only moderate changes in rate of force development, as studied here, not all units respond similarly. This is different from what has been described in the literature for ballistic contractions in other muscle groups, where all motor units respond similarly to the increase in neural drive. Changing the discharge behaviour of a small group of motor units may be sufficient in developing force at the required rate rather than having the discharge behaviour of the entire motor unit pool change equally.
Pemafibrate prevents choroidal neovascularization in a mouse model of neovascular age-related macular degeneration
Authors: Lee Deokho , Nakai Ayaka , Miwa Yukihiro , Negishi Kazuno , Tomita Yohei , Kurihara Toshihide
Published: January 2023

Background

Pathological choroidal neovascularization (CNV) is one of the major causes of visual impairment in neovascular age-related macular degeneration (AMD). CNV has been suppressed by using anti-vascular endothelial growth factor (VEGF) antibodies. However, some clinical cases have demonstrated the failure of anti-VEGF therapies. Furthermore, anti-VEGF agents might induce the development of ocular atrophy. Recently, peroxisome proliferator-activated receptor alpha (PPARα) activation using pemafibrate treatment was suggested as one of the promising therapeutic targets in the prevention of ocular ischemia. However, the preventive role of pemafibrate remains unclear in CNV. We aimed to examine the preventive role of pemafibrate on laser-induced pathological CNV.

Methods

Adult male C57BL/6 mice were orally supplied pemafibrate (0.5 mg/kg) for four days, followed by laser irradiation. Then, pemafibrate was consecutively given to mice with the same condition. CNV was visualized with isolectin-IB4. The eye (retina and/or retinal pigment epithelium [RPE]-choroid), liver, and serum were used for biomolecular analyses.

Results

We found that pemafibrate administration suppressed CNV volumes. Pemafibrate administration activated PPARα downstream genes in the liver and eye (especially, RPE-choroid). Furthermore, pemafibrate administration elevated serum fibroblast growth factor 21 levels and reduced serum levels of triglycerides.

Conclusions

Our data suggest a promising pemafibrate therapy for suppressing CNV in AMD.
La intención de procrear y el interés superior del niño en el contexto de la reproducción asistida
Authors: Rodríguez Pinto María Sara , Fernández Arrojo María
Published: January 2023

Este artículo tiene por objeto proponer el control de idoneidad de los comitentes, la eliminación del anonimato en la donación de gametos y la determinación de la maternidad por el hecho del parto como paradigmas de conciliación entre el interés superior del niño y la intención de uno o más adultos en procrear. Esta proposición responde a una valoración del efecto de las técnicas de reproducción asistida en el derecho de la filiación desde el punto de vista del interés superior del niño. Se critica la reacción normativa que tiende a validar la intención de procrear como fuente de atribución de filiación. Se evalúa la cuestión en aspectos tales como la legitimación de mujeres solas para acceder a las técnicas, la determinación de paternidad en base a la intención de procrear, la doble maternidad y la doble paternidad.
Build Up para o custo de capital próprio do setor sucroenergético brasileiro
Authors: Lima Fabiano Guasti , Neto Alexandre Assaf , Silva Haroldo José Torres da , Gatsios Rafael Confetti
Published: January 2023

A determinação do correto custo de capital próprio no setor sucroenergético sempre foi objeto de interesse e discussão. Este trabalho apresenta o objetivo de propor uma metodologia de análise do custo de capital próprio para organizações brasileiras do setor sucroenergético no Brasil. O estudo se justifica pela reduzida quantidade de pesquisas na área e pela heterogeneidade representativa entre as companhias do setor. O trabalho aplica a metodologia build up, conforme proposto por Pratt (2002), para cálculo do custo de capital próprio, além de comparar os resultados com metodologias tradicionais de análise.. Os resultados apontam para maior aderência da metodologia proposta pelo modelo build up nessa pesquisa, consistindo no cálculo do capital próprio das organizações da área sucroenergética no Brasil, durante o período testado.
A Theoretical Approach of “Invisible Hands” in Public Finance Management: An Urgent Need for Fiscal Policy Sustainability in Developing Countries
Authors: Ewane Enongene Betrand , Elvis Ndodekane
Published: January 2023

The selfish interest of some government officials affects the smooth functioning of the pillars of public expenditure and accountability (PEFA) in public finance management (PFM) through their ‘‘invisible hands”, which deprive the government from achieving its objectives of fiscal policy. This study examines the shortcomings of the pillars of public expenditure and accountability (PEFA) in developing countries and its effects on public finance management (PFM) using a theoretical approach. The study critically examined the functionality of the pillars using a comparative regional and income analysis and why it has not been effective in developing countries. The paper ends up by suggesting key policies that can be used to avoid the selfish interest of individuals in PFM.