bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Changes in Viral Load and Inflammatory Cytokines, as Well as the Occurrence of Secondary Infections, in SFTS Patients Treated with Specific Treatments: A Prospective Multicenter Cohort Study
Authors: Seo Jun-Won , Lee You Mi , Tamanna Sadia , Bang Mi-Seon , Kim Choon-Mee , Kim Da Young , Yun Na Ra , Kim Jieun , Jung Sook In , Kim Uh Jin , Kim Seong Eun , Kim Hyun Ah , Kim Eu Suk , Hur Jian , Kim Young Keun , Jeong Hye Won , Heo Jung Yeon , Jung Dong Sik , Lee Hyungdon , Park Sun Hee , Kwak Yee Gyung , Lee Sujin , Lim Seungjin , Kim Dong-Min
Published: December 2024

Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile illness caused by the SFTS virus (SFTSV). We conducted this study to propose a scientific evidence-based treatment that can improve prognosis through changes in viral load and inflammatory cytokines according to the specific treatment of SFTS patients. This prospective and observational study was conducted at 14 tertiary referral hospitals, which are located in SFTS endemic areas in Korea, from 1 May 2018 to 31 October 2020. Patients of any age were eligible for inclusion if they were polymerase chain reaction positive against SFTSV, or showed a four-fold or higher increase in IgG antibody titers between two serum samples collected during the acute and convalescent phases. On the other hand, patients with other tick-borne infections were excluded. In total, 79 patients were included in the study. The viral load of the group treated with steroids was 3.39, 3.21, and 1.36 log10 RNA copies/reaction at each week since the onset of symptoms, and the viral load in patients treated with plasma exchange was 4.47, 2.60, and 2.00 log10 RNA copies/reaction at each week after symptom onset. The inflammatory cytokines were not reduced effectively by any specific treatment except IVIG for the entire treatment period. Secondary infections according to pathogens revealed four bacterial (26.7%) and one fungal (6.7%) infection in the steroid group. The viral load of SFTSV and inflammatory cytokines cannot be decreased by steroid and plasma exchange treatments. Secondary bacterial infections can occur when steroids are administered for the treatment of SFTS. Therefore, caution should be exercised when choosing treatment strategies for SFTS.
The Pestivirus RNase Erns Tames the Interferon Response of the Respiratory Epithelium
Authors: Beilleau Guillaume , Stalder Hanspeter , Almeida Lea , Oliveira Esteves Blandina I. , Alves Marco P. , Schweizer Matthias
Published: December 2024

Bovine viral diarrhea virus (BVDV), a pestivirus in the family Flaviviridae, is a major livestock pathogen. Horizontal transmission leads to acute transient infections via the oronasal route, whereas vertical transmission might lead to the birth of immunotolerant, persistently infected animals. In both cases, BVDV exerts an immunosuppressive effect, predisposing infected animals to secondary infections. Erns, an immunomodulatory viral protein, is present on the envelope of the virus and is released as a soluble protein. In this form, it is taken up by cells and, with its RNase activity, degrades single- and double-stranded (ds) RNA, thus preventing activation of the host’s interferon system. Here, we show that Erns of the pestiviruses BVDV and Bungowannah virus effectively inhibit dsRNA-induced IFN synthesis in well-differentiated airway epithelial cells cultured at the air–liquid interface. This activity was observed independently of the side of entry, apical or basolateral, of the pseudostratified, polarized cell layer. Virus infection was successful from both surfaces but was inefficient, requiring several days of incubation. Virus release was almost exclusively restricted to the apical side. This confirms that primary, well-differentiated respiratory epithelial cells cultured at the air–liquid interface are an appropriate model to study viral infection and innate immunotolerance in the bovine respiratory tract. Furthermore, evidence is presented that Erns might contribute to the immunosuppressive effect observed after BVDV infections, especially in persistently infected animals.
Evaluation of Safety, Immunogenicity and Cross-Reactive Immunity of OVX836, a Nucleoprotein-Based Universal Influenza Vaccine, in Older Adults
Authors: Jacobs Bart , Leroux-Roels Isabel , Bruhwyler Jacques , Groth Nicola , Waerlop Gwenn , Janssens Yorick , Tourneur Jessika , De Boever Fien , Alhatemi Azhar , Moris Philippe , Le Vert Alexandre , Leroux-Roels Geert , Nicolas Florence
Published: December 2024

Background/Objectives: In a Phase 2a, double-blind, placebo-controlled study including healthy participants aged 18–55 years, OVX836, a nucleoprotein (NP)-based candidate vaccine, previously showed a good safety profile, a robust immune response (both humoral and cellular) and a preliminary signal of protection (VE = 84%) against PCR-confirmed symptomatic influenza after a single intramuscular dose of 180 µg, 300 µg or 480 µg. Methods: Using the same methodology, we confirmed the good safety and strong immunogenicity of OVX836 at the same doses in older adults (≥65 years), a key target population for influenza vaccination. Results: Significant humoral (anti-NP IgG) and cellular (interferon gamma (IFNγ) spot-forming cells per million peripheral blood mononuclear cells and specific CD4+ IFNγ+ T-cells) immune responses were observed at the three dose levels, without clear dose–response relationship. T-cell responses were shown to be highly cross-reactive against various influenza A strains, both seasonal and highly pathogenic avian strains. We also evaluated the effect of sex (stronger immune response in females) and age (stronger immune response in young adults) on the immune response to OVX836 after adjustment based on the pre-vaccination immune status. Conclusions: The results obtained with OVX836 lay the groundwork for a future placebo-controlled, field proof of concept efficacy Phase 2b trial.
Public Awareness and Willingness to Vaccinate Against Herpes Zoster: A Nationwide Cross-Sectional Study in Poland
Authors: Grudziąż-Sękowska Justyna , Sękowski Kuba , Grześczyk-Nojszewska Zuzanna , Kamińska Agnieszka , Sierpiński Radosław , Ostrowski Janusz , Pinkas Jarosław , Jankowski Mateusz
Published: December 2024

Objectives: Herpes zoster (HZ), caused by varicella zoster virus reactivation, affects a significant portion of the population, leading to substantial morbidity. Vaccination is highly effective in preventing HZ, yet awareness and uptake remain low. This study assessed awareness and willingness to vaccinate against HZ in Poland following the introduction of a reimbursement policy. Methods: A nationwide cross-sectional survey (September 2024) using a computer-assisted web interview (CAWI) method collected data from 1137 adults. Factors associated with HZ vaccine awareness and willingness were analyzed using logistic regression models. Results: Only 47% of respondents reported awareness of the HZ vaccine. Television was the primary information source (52%). Factors associated with awareness included chronic disease status (aOR = 1.35, 1.02–1.80, p = 0.04). Willingness to vaccinate was reported by 63.7% of eligible participants, with factors such as the absence of children (aOR = 1.30, 1.01–1.69, p = 0.04) and moderate financial status (aOR = 1.51, 1.04–2.18, p = 0.03) being associated with higher willingness. Conclusions: Significant gaps exist in public awareness and willingness to vaccinate against HZ in Poland. Multifaceted strategies, including targeted media campaigns, enhanced physician engagement and improved access, are needed to increase vaccination rates.
The Relationship of Fish Functional Traits, Physicochemical Characteristics and Exotic Fish (Micropterus salmoides and Lepomis macrochirus)
Authors: Bold Misheel , Kim Kyu-Jin , Yoon Jin-Young , Kim Mooseong , Yoon Juduk , Kim Jae-Goo , Kim Keonhee , Jang Min-Ho
Published: December 2024

An invasive species is defined as a biological species introduced, most often through human action, that causes direct harm, such as reducing or driving native species to extinction. This introduction can result in long-term changes to ecosystem structures and ultimately contribute to a decline in biodiversity within areas where it was not previously present. Thus, continuous monitoring and management are essential. This study examined the impact of two exotic species, largemouth bass (Micropterus salmoides) and bluegill (Lepomis macrochirus), on fish diversity in rivers across South Korea. Data from the “Stream Ecosystem Survey and Health Assessment” project, which was conducted along five major river basins between 2013 and 2021, were analyzed. The data were divided into three periods: 2013–2015, 2016–2018, and 2019–2021, covering a total of 960 sites. The results revealed that largemouth bass and bluegill were present at 360 sites (37.5%) from 2013 to 2015, 325 sites (33.9%) from 2016 to 2018, and 356 sites (37.1%) from 2019 to 2021. Additionally, when comparing sites where exotic fish were present with those where they were absent, the average number of native species was slightly higher in areas where these invasive species were present, yet the average Fish Assessment Index (FAI) value was lower. Statistically significant differences were observed in fish diversity, especially in trophic and tolerance traits. This study provides valuable insight into the impact of invasive species on South Korean river ecosystems and offers important information for developing future conservation and management strategies for biological resources.
Optimization of Maize Irrigation Strategies in the Middle Reaches Irrigation Area of the Heihe River Using a Differential Evolution Algorithm
Authors: Jia Lige , Zhang Bo , Cui Yanqiang
Published: December 2024

Optimizing maize irrigation strategies is essential for improving water use efficiency and crop yields in arid regions. However, limited quantitative research exists on these optimizations. This study focuses on the Heihe River Basin in China, aiming to (1) optimize maize irrigation strategies using a differential evolution (DE) algorithm integrated with the AquaCrop model and remote sensing data; (2) compare the DE algorithm’s performance with the traditional Nelder–Mead (fmin) algorithm regarding yield improvement and irrigation water use; and (3) assess the benefits of different irrigation strategies under limited water availability. Covering 22 irrigation management zones in Zhangye City, Gansu Province, the study utilized soil, weather, and crop data from Google Earth Engine to drive the AquaCrop model. Results indicate that the DE algorithm achieved higher simulated maize yields, increasing by 0.5 to 1 t/ha on average compared to the fmin algorithm, albeit with a 30% rise in irrigation water usage. The integration of both the DE and fmin algorithms with the AquaCrop model facilitates the development of tailored irrigation strategies, providing a scientific foundation for sustainable agricultural water management. These findings can guide efficient irrigation management plans in the region and similar arid systems.
Impact of CO2 Viscosity and Capillary Pressure on Water Production in Homogeneous and Heterogeneous Media
Authors: Zidane Ali
Published: December 2024

This study explores the numerical modeling of CO2 injection in water within a lab-scale domain, where the dimensions are in the order of centimeters, highlighting its diverse applications and significant environmental and economic benefits. The investigation focuses on the impacts of heterogeneity, capillary pressure, and CO2 viscosification on water production. Findings reveal that increasing CO2 viscosity by a factor of 5 drastically influences water production, while further increasing it to a factor of 10 yields minimal additional effect. Capillary pressure notably delays breakthrough and reduces sweeping efficiency (effectiveness of the injected CO2 in displacing water), with a more pronounced impact in slim cores (1 cm) compared to thick cores (3.8 cm). The numerical modeling of CO2 injection in water within a lab-scale domain provides valuable insights into enhanced oil recovery (EOR) techniques. These optimized strategies can improve the efficiency and effectiveness of CO2-EOR, leading to increased oil and gas recovery from reservoirs.
Special Investment Contract Instrument Reforming
Authors:   Lomonosov Moscow State University, Evstafieva Julia
Published: December 2024

In July 2019 the Federal Law of December 31, 2014 N 488-FZ “On industrial policy in the Russian Federation” that determines legal and regulatory basis of the usage of special investment contract instrument (SPIC) was extensively revised. At this moment a package of new secondary legislation is being developed, regulatory framework in the sphere of SPIC is due to be reviewed locally. The article analyses key changes and distinctions between ‘SPIC 2.0’ and the previously used variant of the instrument. In the article there are given the results of SPIC’s application in the previous version during 4-year period. Taking into account that the reviewed changes of the instrument not only clarifies its content and masters its application but also changes subject focus of SPIC one can be talking about complex reforming of the instrument at present time.
Phytochemicals as immunomodulating agents in melanoma
Authors:   Federal State Autonomous Educational Institution of Higher Education «North-Eastern Federal University named after M. K. Ammosov», Yakutsk, Russia, Egorov A. N.
Published: December 2024

The article examines the role of phytochemicals as immunomodulating agents in the
prevention and treatment of melanoma. The main mechanisms of action of phytochemicals
on the immune system and their impact on the development and progression of melanoma
are discussed. Examples of experimental and clinical studies confirming the effectiveness of
phytochemicals in oncology practice are given. The prospects for the use of phytochemicals
in combination with conventional therapy methods and the possibility of their application in
personalized medicine are highlighted.
Ferritin: deficiency symptoms and signs, laboratory diagnostics
Authors:   Medical Institute, Peoples Friendship University of Russia, Moscow, Russian Federation, Yusupova G. K.
Published: December 2024

Ferritin is a protein complex in which iron is stored in tissues. The main biological role of ferritin is the accumulation of iron, which is toxic to the body, but ferritin converts it into a physiologically available state and into a soluble, non-toxic form.
Modern pharmacotherapy approaches to treating chronic obstructive pulmonary disease. Part 2: Algorithms from the standpoint of current clinical guidelines
Authors:   FSAEI CPE Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, FSAEI HE Pirogov Russian National Research Medical University,Moscow, Maksimov M.L. , Bontsevich R.A. ,   Kazan State Medical Academy - Branch of the FSBEI CPE Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Kazan; FSBEI HE Mari State University, Yoshkar-Ola, Shikaleva A.A. ,   Kazan State Medical Academy - Branch of the FSBEI CPE Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Kazan
Published: December 2024

The review article contains current information on the main groups of drugs and al
gorithms for their use in chronic obstructive pulmonary disease (COPD). Pharmacotherapy of
stable COPD and exacerbations is presented. The information is based on current national and
international guidelines for the treatment of COPD. Oxygen therapy, pulmonary rehabilitation and
prevention methods are briefly presented. Approaches to treating a patient with signs of both
bronchial asthma and COPD are given.
Geometric rigidity of sections in the form of in torsion
Authors: Korobko A. V. , Kalashnikova N. G.
Published: December 2024

This article is a generalization of known solutions to the problem of determining the reduced geometric stiffness of sections of elastic prismatic beams using geometric arguments: the shape coefficient and the ratio of conformal radii (internal to external). Analytical dependences are constructed for all considered sections (regular polygons, ellipses, rectangles, isosceles and right triangles): reduced geometric stiffness is the coefficient of shape and reduced geometric stiffness is the ratio of conformal radii. Formulas in the form of polynomials for determining the ratio of conformal radii are also constructed for these sections. An analysis of the changes in both arguments under various geometric transformations showed that the ratio of conformal radii has similar isoperimetric properties as the shape coefficient. This allows to determine the geometric torsional stiffness of the sections by interpolation.
REINFORCEMENT LEARNING-BASED INTELLIGENT CONTROL FOR STEWART PLATFORM
Authors: Duyun I. , Kabalyants P. , Duyun T. , Rybak L.
Published: December 2024

This article presents an intelligent control system for the Stewart platform, a parallel kinematic mechanism with six degrees of freedom. One of the main challenges of such mechanisms is the presence of singular positions within the workspace, which can lead to instability. Standard control algorithms often prove ineffective when navigating these potentially unstable zones. Therefore, the proposed control system utilizes Reinforcement Learning, a type of machine learning, as its core component. The choice of this method is motivated by its effectiveness in continuous action spaces, which is crucial for ensuring smooth movement within a workspace with variable coordinates. In conditions involving operational loads, vibrations, and temperature fluctuations, real-time correction is necessary. The application of an artificial neural network enhances accuracy and flexibility, enabling the system to adapt to changing operational conditions without compromising performance by modeling complex nonlinear dependencies and learning from accumulated experience. The paper discusses the following aspects of the control system: the working scheme and overall architecture of the reinforcement learning method, the learning algorithm scheme, UML diagrams of the environment and agent classes, the architecture of the actor-critic network, the network training process, and the results of its testing, which demonstrate high efficiency in its application.
THE EFFECT OF ADDITIVES ON THE STRENGTH PROPERTIES OF WEDGING AGENTS SYNTHESIZED ON THE BASIS OF DRILLING WASTE
Authors: Golovko D.
Published: December 2024

The article considers the main directions of research in the field of technology of aluminosilicate materials. A new type of materials used in the production of propants has been established – ore dressing waste. Nowadays, quite a lot of research teams are engaged in developments in the synthesis of propants. The most prominent scientific collectives of the world are considered. It is shown that China is the leader in the research of this type of materials. At the moment, positive results have been obtained on the use of waste from the enrichment of phosphate rocks, iron, titanium, germanium, and lead-zinc ores. The main provisions of the research are described, and a conclusion is made about the prospects of using this type of materials in the technology of aluminosilicate propants, especially for regions with a developed mining industry. The predominant oxides are Al2O3 and SiO2. This lies in the fact that aluminum oxide has a direct effect on the strength characteristics, and silicon oxide on the plasticity of the raw material mixture, which is necessary for forming propane granules. Nevertheless, an increase in the proportion of Al2O3 to 96.0 wt. % leads to the appearance of fragility in propants due to their strong shell and hollow center. These characteristics limit their use in the oil production process. During the study, drilling sludge obtained from the Zapadno-Varavenskoye field, which is located in the Slavyansky district of the Krasnodar Territory, just 3.5 km from the Mostovyansky farm, was selected.
نموذج التقييم التفاعلي ثنائي الإجراء للتدريب والتطوير
Authors: الخياط رضا محمد , تقي عبدالعزيز عبدالمحسن
Published: December 2024

يعد التقييم التفاعلي للتدريب من أكثر النماذج المستخدمة لتقييم أنشطة التدريب من بين نماذج كير كباترك الأربعة. وحتى يتسنى فهم العوامل المؤثرة في تكوين ردة فعل المتدرب للبرامج التدريبية، فقد تم تطوير واختبار نموذج للتقييم التفاعلي ثنائي الإجراءات. تشير نتائج الاختبارات إلى أن التقييم اليومي (الإجراء الأول)، ومتغير الوقت، ومجموعتين من المتغيرات الصورية المتعلقة بتصنيف البرامج، ذات علاقة بالتقييم النهائي (الإجراء الثاني). وهذا يقودنا إلى نتيجة مؤداها أن ردة فعل المتدرب لبرنامج التدريب ليس ناتجا فقط من تفاعله مع أحداث اليوم الأخير للبرنامج، إنما ناتج عن تعرضه للأحداث اليومية للبرنامج ككل. وقد أثبت اختبار تحليل الانحدار ذلك، حيث أثبت الاختبار أن التقييم اليومي للبرنامج متنبأ جيد لردة فعل المتدرب، كما أثبت الاختبار أن متغيرات التقييم النهائي للبرنامج، باستثناء متغير الترتيبات الإدارية، قادرة على تفسير المتغيرات التي تكون الانطباع النهائي للمتدرب عن البرنامج.
العلاقة بين بعض أنواع اتصال الرئيس-المرؤوس والرضا الوظيفي: دراسة استكشافية
Authors: اليامي أحمد مداوس
Published: December 2024

يهدف هذا البحث إلى دراسة العلاقة بين أربعة من أبعاد عملية اتصال الرئيس- المرؤوس والرضا الوظيفي، وذلك وسط عينة عشوائية تشمل أربعة مستويات تنظيمية لإحدى شركات الخدمات العامة، في المملكة العربية السعودية. توصلت الدراسة إلى عدد من النتائج هي: (1) أن هناك تبايناً في الرضا الوظيفي بين مديري الشعب (المستوى الإشرافي الثاني) والمجموعات الثلاث الأخرى التي تحت الدراسة. (2) أن هناك علاقة طردية بين الاتصال المتعلق بالوظيفة والرضا الوظيفي بغض النظر عن المستوى التنظيمي. (3) أن هناك علاقة طردية بين الاتصال الإيجابي والرضا الوظيفي في ثلاث مجموعات من المجموعات الأربع التي تحت الدراسة. (4) أن هناك علاقة عكسية بين الاتصال السلبي وبين الرضا الوظيفي بغض النظر عن المستوى التنظيمي.
الأداء المالي وقيمة الشركة: دراسة للشركات الصناعية الكويتية
Authors: الوقيان عادل عبدالله , الشمري تركي بادي
Published: December 2024

تقوم هذه الدراسة بتحليل العلاقة بين الأداء المحاسبي والأداء المالي لمجموعة الشركات الصناعية الكويتية والمقيدة في سوق الكويت للأوراق المالية. ويهدف التحليل المتبع إلى اكتشاف فيما إذا كان المستثمر في سوق الأوراق المالية يقوم باستخدام البيانات المحاسبية والقوائم المالية المنشورة في التقارير المالية السنوية عند اتخاذ قراره الاستثماري. ومن أهم النتائج التطبيقية لهذه الدراسة هو عدم وجود علاقة بين أسعار أسهم الشركات الصناعية وبين بياناتها المحاسبية التي تعبر عن أدائها السنوي. وهذه النتيجة تبين أن المستثمرين في سوق الأوراق المالية الكويتية لا يربطون بين أداء الشركة وسعر سهمها السوقي، على الأقل بالنسبة لفترة الدراسة. ولهذه النتيجة مؤشرات مهمة على صعيد كفاءة سوق الكويت للأوراق المالية ومدى سيادة ما يعرف بالمستثمر "المتذبذب" بالإضافة إلى العلاقة بين العائد والمخاطرة بالنسبة للمستثمر الكويتي.
دراسة تحليلية انتقادية لمعايير المراجعة الدولية لبيان مدى إمكانية تطبيقها على المستوى المحلي
Authors: الشامي مصطفى أحمد
Published: December 2024

تهدف هذه الدراسة إلى بيان مدى ملاءمة معايير المراجعة الدولية للتطبيق على المستوى المحلي بالدول المختلفة، ومدى إمكانية الاسترشاد بها في وضع معايير مراجعة محلية ذات جودة مناسبة. ولقد أوضحت الدراسة أنه على الرغم من أن بيانات المعايير الدولية اشتملت بصفة عامة على متطلبات معايير المراجعة المتعارف عليها، فإن هناك نوعاً من عدم الاتساق في إطارها العام، كما أن هناك قصوراً واضحاً في معالجتها لبعض الجوانب المتعلقة ببعض الموضوعات المهمة، ولقد بينت الدراسة بشئ من التفصيل أوجه القصور تلك، وأوصت بعدم الاعتماد على معايير المراجعة الدولية مصدراً وحيداً تؤخذ عنه معايير المراجعة المحلية.
Nutritional Management of Cancer Patients Undergoing Chemotherapy and Chemoradiation Therapy
Authors: Sakurai Yoichi
Published: December 2024

Although chemotherapy and chemoradiation therapy improve the clinical outcomes and decrease locoregional failure in patients with advanced cancer, they may lead to an increased risk of malnutrition in these patients due to their gastrointestinal side effects. Many cancer patients are already malnourished as a result of their cancer-bearing status. Consequently, these patients experience poor clinical outcomes due to various infectious and noninfectious complications. Nutritional management that is based on frequent monitoring of the nutritional status of patients can ensure that they receive adequate calories and certain nutrients, which is vital to improve their clinical outcomes and quality of life.
Muscle Loss in Cancer Patients: Pathophysiology and Impact on the Outcome
Authors: Salandini Maria Chiara , Pecorelli Nicolò , De Nardi Paola , Braga Marco
Published: December 2024

A generalized loss of skeletal muscle can be associated with malnutrition, cancer, inflammation or neurodegenerative processes. Most cancer patients undergoing surgery are sarcopenic although only a minority of them suffer from severe weight loss. The cancer stage is a major determinant of sarcopenia, while nutritional factors seem to be less important. In cancer patients sarcopenia has been associated with a worse physical performance, a reduced response to chemotherapy and radiotherapy, a higher postoperative morbidity rate, and a reduced life expectancy.
Comorbilidad cardiaca en epilepsia: una revisión bibliográfica
Authors: Alvarado Arguedas José Julián , Sequeira Quesada Carlos Mario , Santillán Zuñiga Juan Rafael , Jiménez Rivera Ariel David , Rodríguez Arroyo Daniela
Published: December 2024

La epilepsia es una enfermedad caracterizada por crisis epilépticas recurrentes debido a actividad neuronal anormal o excesiva a nivel cerebral. Dichas crisis están asociadas a un aumento en comorbilidad cardiaca. En primer lugar, se ha evidenciado una relación de la epilepsia con arritmias cardiacas, siendo la más prevalente la taquicardia sinusal. Además, entidades como bloqueos AV o incluso asistolia se han visto asociados. Diversos mecanismos se han estudiado como los causantes, entre los que destacan alteraciones a nivel de canales iónicos, los cuales en muchos casos están asociados con alteraciones genéticas en canales que se encuentran tanto a nivel cerebral como cardiaco. Otro aspecto importante es la presencia de cambios estructurales, así como cambios moleculares a nivel cardiaco entre lo que se ha evidenciado disfunción sistólica y diastólica, además de hipertrofia ventricular. Asimismo, se ha encontrado la asociación de epilepsia con aumento en la prevalencia de factores de riesgo cardiovasculares y la afectación directa por medicamentos. En esta revisión bibliográfica se evidencia que todos estos factores cumplen un papel en el riesgo cardiovascular, sin embargo, no en todos se ha encontrado una relación estadísticamente significativa, principalmente por problemas al diferenciar la relación directa con la mortalidad cardiovascular.
Ashoughs and poets in the 17th–19th Eastern Armenian and Iranian café houses
Authors:   Yerevan State University History Museum, Saroyan T. E. ,   Mesrop Mashtots Research Institute of Ancient Manuscripts
Published: December 2024

The study endeavors to examine the dynamics of movement, posture,
and social interactions within cafés operating in the two neighboring
countries during the 17th to 19th centuries. These establishments, which
began their global spread in the 17th century, served as quintessential
gathering places for men in Eastern societies, where various discussions
took place amidst the accompaniment of ashough music and poetic recitations. They were venues where the intellectual and creative figures
of the era – writers, musicians, and artists – regarded cafés as the ideal
platform for self-expression, thus becoming the centres of contemporary performances, festivities, and multicultural exchanges. Due to the
deepening cultural relations, artists from neighboring regions, such as
Iran and Armenia, frequently performed in cafés across both countries,
thereby fostering a reciprocal exchange of artistic expression. This is
why many Armenian public figures of the time – musicians and writers
enjoyed recognition in Iran and possessed knowledge of the Persian language. Similarly, a comparable environment was established in cafés
operating within Armenia, where prominent Persian artists showcased
their talents. Nevertheless, with hanging times and the evolving nature
of artistic expression, cafés gradually lost their prestige as primary centres of entertainment and transformed into more inclusive spaces frequented by the general public. Today, they continue to serve as venues for live music, book presentations, and lectures, retaining a legacy of
cultural significance.
Spontaneous Rupture of the Esophagus – Boerhaave’s Syndrome
Authors: Rustamzade U. , Jafarov Ch. , Gasimov E.
Published: December 2024

Introduction. Spontaneous rupture of the esophagus is a complex and difficult to diagnose pathology that requires early surgical intervention to avoid the development of possible serious complications. Purpose. To study the possibilities of early diagnosis and choice of method of surgical treatment of spontaneous rupture of the esophagus, complicated by purulent mediastinitis and pleuritis. Materials and methods. We observed 6 patients with spontaneous esophageal rupture complicated by mediastinitis and pleuritis. The diagnosis was established on the basis of a comprehensive anamnestic, radiological, computed tomographic and endoscopic examination. Results. 1 patient refused surgery. Surgical treatment was performed in 5 patients, 4 of whom recovered, 1 patient died. Conclusion. Spontaneous rupture of the esophagus is a rare pathology, which without the necessary early diagnosis and timely surgical treatment leads to serious complications, with inevitable death.

Введение. Спонтанный разрыв пищевода является сложной и трудно диагностируемой патологией, требующей раннего хирургического вмешательства для предотвращения развития возможных грозных осложнений. Цель. Изучить возможности ранней диагностики и выбора метода хирургического лечения спонтанного разрыва пищевода, осложненного гнойным медиастинитом и плевритом. Материалы и методы. Проведено наблюдение за 6 пациентами со спонтанным разрывом пищевода, осложненным медиастинитом и плевритом. Диагноз установлен на основании комплексного анамнестического, рентгенологического, компьютерно-томографического и эндоскопического исследований. Результаты. Один пациент отказался от операции. Оперативное лечение выполнено 5 пациентам, 4 из которых выздоровели, 1 – умер. Заключение. Спонтанный разрыв пищевода является редкой патологией, которая без необходимой ранней диагностики и своевременного хирургического лечения приводит к грозным осложнениям с неминуемым летальным исходом.
Estructuras de participación del actor social en la renovación urbana
Authors: Sterling Sadovnik Juan Jacobo
Published: December 2024

El desarrollo sostenible de áreas pericentrales requiere un modelo de ocupación que fomente la equidad. La participación ciudadana se presenta como elemento clave para sustentarlo a través de relaciones virtuosas entre actores. El objetivo del artículo es destacar el papel de propietarios, residentes –presentes y futuros– en la configuración del tejido social visualizando formas de asociación que viabilicen su participación.El análisis del contexto físico y social, en el caso de estudio El pericentro sur de Cali, identifica las características de la comunidad que impulsarán la renovación urbana. El conocimiento detallado del contexto, contrastado con experiencias nacionales e internacionales, facilita la estructuración de mecanismos y herramientas que promuevan una participación efectiva y vinculante.El tejido social consolidado, las formas de asociación variadas y los instrumentos de gestión, planificación y financiación normativamente disponibles son las cualidades que sustentan la renovación de las áreas pericentrales como estrategia de desarrollo urbano sostenible, equitativa y paulatina.
Hacia un modelo para un Diseño decolonial y no excluyente en Argentina
Authors: Pittaluga Mariana
Published: December 2024

Este trabajo explora la necesidad de un enfoque de Diseño en Argentina, que sea decolonial y no excluyente, para poder abordar las problemáticas sociales complejas que enfrenta el país en la actualidad. La hipótesis central del trabajo es que un modelo de Diseño basado en la teoría de la complejidad, el codiseño y el diseño para las transiciones, desde una perspectiva decolonial y no excluyente, puede ser una herramienta eficaz para afrontar estos desafíos. Se argumenta que los modelos tradicionales de diseño, con su enfoque eurocéntrico, no se adaptan a las realidades y necesidades del contexto argentino.Se analiza cómo la importación de modelos extranjeros ha perpetuado una dinámica colonialista que ignora las particularidades y la diversidad cultural de Argentina. Se plantea la necesidad de trascender las metodologías tradicionales y construir un Diseño que emerja de las realidades locales, tomando en cuenta los aspectos culturales propios del país.En definitiva, se busca ofrecer una herramienta para la práctica de un Diseño decolonial y no excluyente, con un esquema de trabajo que guía a los diseñadores en la consideración de diferentes variables y ejes de análisis. Esta herramienta, que se presenta como un punto de partida para una práctica más integral, responsable y transformadora en Argentina, busca promover un enfoque sensible a las necesidades y realidades locales, considerando la diversidad cultural y social del contexto argentino.
Historias para el Diseño. Experiencias en el aula-taller de Pensamiento Contemporáneo, FAUD-UNMDP
Authors: Kaczan Gisela Paola
Published: December 2024

Este manuscrito comparte la experiencia desarrollada en el segundo nivel del Taller Vertical de Pensamiento Contemporáneo, perteneciente a la subárea de conocimiento histórico-social, de la carrera de Diseño Industrial, Facultad de Arquitectura, Urbanismo y Diseño, Universidad Nacional de Mar del Plata.En este marco, se busca pensar el diseño en retrospectiva para identificar y rastrear procesos situados, entendiendo que la lectura interdisciplinaria entre diseño y contexto habilita el conocimiento crítico de lo producido, permite hacer interpretaciones y transferencias a diferentes áreas y escalas del diseño, a diferentes tiempos y territorios geográficos.Entendiendo que en la carrera de Diseño Industrial, teoría y proyecto se retroalimentan, la asignatura se dispone como un taller teórico-práctico en torno a cinco ejes cronológicos entre el siglo V y el siglo XVII en diferentes regiones europeas. Esto implica indagar en procesos del diseño, antes de la revolución industrial y la aparición del diseñador/a como sujeto, procesos que articulan transferencias a la cultura material del tiempo presente.
Acompañar la vuelta
Authors: Chemelli Florencia
Published: December 2024

Los tiempos de pandemia a causa del COVID 19 marcaron un antes y después dentro del ámbito educativo, provocando que la vuelta a la presencialidad en las cursadas en 2022 significara un reto. En ese año se recibieron en las aulas estudiantes que cursaron a distancia durante dos años, en el aislamiento de sus hogares, sin haber acudido con anterioridad a la universidad.
En la carrera de Arquitectura, el espacio de taller junto a las dinámicas grupales son la base en la enseñanza de todas las asignaturas de la carrera. Por ende, la vuelta a la presencialidad resultó una oportunidad y un desafío significativos para docentes y estudiantes.
Pensar la educación superior postpandemia, requiere de un alto compromiso por parte de los docentes, con la necesidad de adoptar estrategias que acompañen a los estudiantes ante la nueva realidad. En este sentido, la evaluación de los aprendizajes como instancia de formación es una oportunidad de monitoreo y acompañamiento necesarios.
Este trabajo aborda la experiencia deriva de autoevaluación realizada en el taller de la asignatura Historia de la Arquitectura en la UNDAV, como herramienta de acompañamiento para los estudiantes que regresan a la presencialidad, fomentando prácticas reflexivas y críticas en el proceso de formación universitaria.
Educational innovation: an approach to the japanese Kaizen method in university students. Reflections and perspectives
Authors: Carrillo-Beltrán Julio César Cuauhtémoc , Llanos-Ramírez María del Carmen , Ramírez-Jiménez Armando , Bogarin-Correa María Romelia
Published: December 2024

The article explores the implementation of the Kaizen method in a Mexican university educational context. The research, conducted at a public university, focused on 174 students from different semesters of bachelor’s degrees in administration, Accounting, Marketing, and International Business. The main objective was to analyze the influence of Kaizen on the development of learning skills and the improvement of academic performance. The research was based on a survey conducted through Google Forms, to collect information about students'
perceptions of the Kaizen method. The results revealed that the method had a positive impact on student motivation and participation. Increased individual responsibility for learning was observed, as well as an increase in collaboration and the search for joint solutions to problems. Students emphasized the importance of the focus on continuous improvement and the importance of constant feedback for the development of their abilities. However, some difficulties were also identified, such as the need for greater support from teachers to implement the method effectively. Therefore, the Kaizen method presents significant potential to improve the quality of university education in Mexico. Its integration into study programs is recommended, with a focus on teacher training and the development of strategies to facilitate its implementation and ensure its effectiveness.
Reappearance of the little bustard Tetrax tetrax in Algeria after more than 30 years of extinction
Authors: Cheikh Ibrahim , Chedad Abdelwahab , Mansouri Abderrahman , Cheikh Adem
Published: December 2024

The Little Bustard Tetrax tetrax has been considered extinct in Algeria and Africa since the 1980s, except in Morocco, where its presence is restricted to limited areas and small numbers. We used the Progressive Frequency Sampling method to record the sightings of this species from August 2023 to January 2024 in its known Algerian range, which is at the Macta Marsh and Lake Telamine in the northwest of the country. We also gathered data from surveys with local residents, farmers, and even expert hunters to get as much information as we could. We have observed the species at Macta on multiple occasions, noticing its fluctuating numbers from year to year and from season to season. In November 2016, the largest group was recorded, consisting of over 100 individuals, and in June 2013, 15 juveniles were observed in the same area, especially in lucerne orchard, confirming its breeding. After more than 30 years of extinction, it is evident that this species has returned, with a mix of resident breeding individuals and overwintering migratory ones.
A AUTOPERCEPÇÃO DE SAÚDE DE CUIDADORES DE CRIANÇAS COM AUTISMO E AS BARREIRAS E FACILITADORES DE ACESSO À SAÚDE: UM ENSAIO TEÓRICO-REFLEXIVO
Authors: Pablo Mangueira Lunguinho Juan , Tavares Pinheiro Yago
Published: December 2024

Os Transtornos do Espectro do Autismo (TEA) apresentam desafios relacionados à comunicação e interação social, além de comportamentos restritos e repetitivos. O TEA afeta não apenas a criança, mas também a dinâmica familiar, causando estresse e impactando o bem-estar dos envolvidos. A adaptação e o ajuste familiar são possíveis, mas exigem mudanças significativas na rotina, o que pode gerar conflitos. A falta de suporte adequado aos cuidadores pode comprometer a qualidade de vida dessas famílias. Profissionais da saúde têm um papel crucial em oferecer apoio e estratégias para que os cuidadores possam lidar melhor com o estresse. Assim, o objetivo deste ensaio teórico foi discutir conceitos e apresentar reflexões sobre a percepção de saúde de cuidadores de crianças com autismo, além de destacar algumas barreiras e facilitadores no acesso dessa população à assistência à saúde. Para a análise, foram revisados 13 documentos que abordam as barreiras no acesso à saúde de cuidadores e adultos autistas, com foco em países como Estados Unidos, Reino Unido e Canadá. Desses documentos, 10 atenderam aos critérios de elegibilidade, sendo publicados nos últimos cinco anos. As metodologias utilizadas incluíram revisão de literatura, estudos transversais e revisões sistemáticas. As amostras variaram de 8 a 1.248 participantes, abrangendo adultos autistas, cuidadores e profissionais de saúde. As principais barreiras identificadas foram: dificuldades de comunicação, sensibilidade sensorial, desconhecimento sobre o autismo, estresse, desafios logísticos, uso limitado de tratamentos personalizados, lacunas no conhecimento sobre os serviços disponíveis, além de questões relacionadas a idioma e custo. Por outro lado, destacaram-se como facilitadores a confiança, o respeito entre pacientes e profissionais, o suporte coordenado e uma comunicação clara.

Palavras-chaves: Transtorno do Espectro Autista. Autorrelato de saúde. Assistência à saúde.
PRESCRIÇÃO FARMACÊUTICA DE MEDICAMENTOS EM FARMÁCIAS E DROGARIAS: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: França Gonçalves Sinara , Guilherme Ferreira Marques Galvão José , Islene Holanda Moreira Carla , de Oliveira Nóbrega Rafaela
Published: December 2024

INTRODUÇÃO: A prescrição farmacêutica de medicamentos em farmácias e drogarias é uma prática em crescimento. Historicamente, os farmacêuticos desempenharam um papel fundamental na dispensação de medicamentos prescritos por médicos, verificando as receitas e fornecendo orientações sobre o uso correto dos medicamentos. A prescrição farmacêutica pode oferecer uma série de benefícios para os pacientes, incluindo agilidade e rapidez no atendimento. OBJETIVO: Analisar as contribuições e os desafios da prescrição farmacêutica de medicamentos em farmácias e drogarias. MÉTODO: O percurso metodológico inclui uma revisão integrativa da literatura realizada em sites de busca de dados online como Scielo, Lilacs, Pubmed e Pepsic a partir dos descritores: prescrição farmacêutica, medicamentos e saúde. Os critérios de inclusão consideram artigos brasileiros, publicados nos últimos cinco anos e cujos resumos estejam alinhados com os objetivos desta pesquisa. RESULTADOS: A pesquisa revela que a prescrição farmacêutica pode reduzir problemas como automedicação, além de facilitar o acesso a cuidados de saúde e promover a educação em saúde entre os pacientes. No entanto, também foram identificados desafios, como a necessidade de formação contínua e adequação às normativas, que devem ser superados para que a prática se consolide e traga benefícios significativos à população. CONCLUSÃO: a partir dos resultados obtidos conclui-se que a prescrição farmacêutica contribui para a melhoria na adesão ao tratamento e a otimização do uso de medicamentos de forma responsável e segura, evitando danos e prejuízos ao paciente.

PALAVRAS-CHAVE: Prescrições. Farmácia. Medicamentos. Saúde.
RISCOS DO TEMPO EXCESSIVO DE TELAS NO DESENVOLVIMENTO DE TRANSTORNOS MENTAIS E DE NEURODESENVOLVIMENTO EM CRIANÇAS: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Ferreira de Morais França Albero , Nunes da Silva Edinete , do Nascimento Andrade Feitosa Ankilma , Amanda Mota Seabra Cícer , Lima França Jessica
Published: December 2024

O uso excessivo de dispositivos tecnológicos está inserido fortemente no mundo moderno, alterando formas de comunicação trabalho e aprendizado. Porém vem reduzindo as interações sociais e acarretando em diversos desfechos adversos, como ansiedade, depressão e outros transtornos, especialmente em crianças. Por meio de uma revisão integrativa da literatura, este estudo teve o objetivo de avaliar se existe uma relação entre o tempo excessivo de telas e o desenvolvimento ou aumento dos sintomas de transtornos mentais e de neurodesenvolvimento em crianças. Após a aplicação das estratégias de buscas nas bases de dados Pubmed, Scielo e LILACS e posterior consideração dos critérios de inclusão e exclusão, foram avaliados 48 artigos, publicados entre 2019 e 2024. Os achados demonstraram algumas associações positivas entre o uso excessivo de telas em crianças com alterações comportamentais, atrasos de desenvolvimento, problemas de comunicação, dificuldades motoras, desenvolvimentos de transtornos mentais e intensificação dos sintomas dos transtornos de TEA e TDAH. Ainda, foram observadas alterações cerebrais estruturais nas crianças que tinham um tempo de tela maior, acarretando em problemáticas no processamento de emoções, qualidade de sono e cognição. Crianças que tiveram o uso de telas iniciados mais precocemente também tiveram prejuízos sociais e maiores riscos do desenvolvimento dessas condições. Fatores socioeconômicos, qualidade da parentalidade e condições familiares também podem influenciar ou aumentar esses desfechos. A conscientização do uso de forma equilibrado, principalmente nos primeiros anos de vida, é essencial para um desenvolvimento infantil saudável.

Palavras-chave: Transtornos Mentais; Transtornos do Neurodesenvolvimento; Criança.
Perilaku Penyiaran Jurnalistik Serta Standar Program Siaran Dalam Bentuk Hidden Camera dan Doorstoping di Era 4.0
Authors: Azizah Muthia Dini
Published: December 2024

Every action taken by the government must have a strong legal basis so as not to conflict with the legislation. This research was conducted with the aim of knowing how the form of legal arrangements in the implementation of television broadcast content according to laws and regulations and how the responsibility of broadcast organizers in organizing television broadcast content in accordance with laws and regulations. The research method used is library research, which is a series of activities related to library data collection methods. The findings in this article are related to the concepts of fairness, accuracy and impartiality, which are very important in upholding the law and truth. Reporting events of panic, riots and conflicts is crucial to ensuring public safety and addressing their impact, even though there is no specific law governing such matters. Finally, the use of hidden cameras has legal and ethical implications that must be considered in accordance with the Electronic Information and Transaction Law and its amendments to prevent legal violations and protect public privacy.
PENGARUH PELATIHAN DIGITAL MARKETING TERHADAP KEBUTUHAN DAN TANTANGAN IMPLEMENTASI DI KALANGAN WIRAUSAHA MUDA PEMULA DI BANJARMASIN
Authors: Agustino Lalu , Ridhoni Muhammad , Nawawi Muhammad
Published: December 2024

Penelitian ini mengkaji kebutuhan pelatihan digital marketing serta dampak pelatihan tersebut terhadap peningkatan pengetahuan dan keterampilan wirausaha muda pemula di Banjarmasin. Menggunakan metode kuantitatif, penelitian melibatkan 50 responden yang telah mengikuti pelatihan. Data dikumpulkan melalui kuesioner pre-test dan post-test, yang mengukur perubahan pengetahuan dan keterampilan sebelum dan sesudah pelatihan. Hasil analisis menunjukkan peningkatan signifikan dalam pengetahuan (dari skor rata-rata 2,75 menjadi 4,25) dan keterampilan (dari 2,5 menjadi 4,0), dengan uji t berpasangan yang signifikan secara statistik (p < 0,001). Selain itu, kebutuhan pelatihan utama yang teridentifikasi meliputi strategi media sosial, analisis data, dan pembuatan konten digital. Kesimpulannya, pelatihan digital marketing efektif dalam meningkatkan kompetensi wirausaha muda dan memberikan wawasan untuk mengembangkan program pelatihan yang lebih relevan. Hasil penelitian ini diharapkan dapat mendukung pengembangan daya saing wirausaha muda di era digital melalui program pelatihan yang terarah.
Kata kunci: Pemasaran digital, pelatihan, pengusaha muda, pengetahuan, keterampilan