bluuebunny/crossref_metadata_2025 huggingface dataset:
Jam Kerja, Adversity Quotient, dan Motivasi: Dinamika Kinerja Karyawan Alfamidi di Nusaniwe, Kota Ambon
Authors: Maghfirah Nurul , Leuhery Ferdy , Sitaniapessy Gloria Nia
Published: August 2024

This study aimed to determine the effects of variable working hours, adversity quotient, and work motivation on Alfamidi employee performance in Nusaniwe District, Ambon City. The study's sample consisted of 47 Alfamidi employees chosen at random. The data was analyzed using SPSS Multiple Regression analysis, which employed descriptive and inferential statistics. The results showed that work motivation, adversity quotient, and working hours significantly positively impacted Alfamidi Employee Performance in Nusaniwe District, Ambon City. The study's findings indicate that Alfamidi Employee Performance in Ambon City's Nusaniwe District will benefit from increased working hours, the adversity quotient, and work motivation.

Keywords: Working Hours, Adversity Quotient, Work Motivation, Employee performance

Abstrak
Tujuan dari penelitian ini adalah untuk mengetahui pengaruh jam kerja, adversity quotient, dan motivasi kerja terhadap kinerja karyawan Alfamidi di Kecamatan Nusaniwe, Kota Ambon. Sampel sebanyak 47 karyawan Alfamidi diambil dengan menggunakan teknik random sampling. Analisis data dilakukan dengan menggunakan analisis Regresi Berganda SPSS, yang menggunakan statistik deskriptif dan inferensial. Hasil penelitian menunjukkan bahwa motivasi kerja, adversity quotient, dan jam kerja berpengaruh positif signifikan terhadap Kinerja Karyawan Alfamidi di Kecamatan Nusaniwe, Kota Ambon. Kesimpulan dari penelitian ini menunjukkan bahwa dengan meningkatkan jam kerja, adversity quotient, dan motivasi kerja akan meningkatkan kinerja karyawan Alfamidi di Kecamatan Nusaniwe, Kota Ambon.

Kata kunci: Jam Kerja, Adversity Quotient,Motivasi Kerja, Kinerja Karyawan
Pengaruh Gaya Kepemimpinan Dan Kualitas Pelayanan Terhadap Kinerja Karyawan
Authors: Pratama A Irfan Wahyudi , Sahabuddin Romansyah , Natsir Uhud Darmawan , Burhanuddin Burhanuddin , Ruma Zainal
Published: August 2024

This study aims to determine the effect of leadership style and service quality on employee performance at PT Bank Negara Indonesia (Persero) Tbk. Bulukumba Branch Office. This research variable includes leadership style, service quality, and employee performance. This type of research is quantitative associative. The population has 44 employees at PT Bank Negara Indonesia (Persero) Tbk. Bulukumba Branch Office. The sampling technique used was saturated sampling with a sample size of 44 respondents, namely the entire population. The data collection technique was carried out by distributing questionnaires to employees. Data analysis techniques were simple regression with the help of SPSS software version 25. The results of this study indicate that leadership style and service quality have a positive and significant effect partially on employee performance at PT Bank Negara Indonesia (Persero) Tbk. Bulukumba Branch Office. Simultaneously, the influence of leadership style and service quality significantly affects employee performance at PT Bank Negara Indonesia (Persero) Tbk. Bulukumba Branch Office.

Keywords: Leadership Style, Service Quality, Employee Performance

Abstrak
Penelitian ini bertujuan untuk mengetahui Pengaruh Gaya Kepemimpinan Dan Kualitas Pelayanan Terhadap Kinerja Karyawan Pada PT. Bank Negara Indonesia (Persero) Tbk. Kantor Cabang Bulukumba. Variabel Penelitian ini terdiri dari gaya kepemimpinan, kualitas pelayanan dan kinerja karyawan. Jenis penelitian ini adalah kuantitatif bersifat asosiatif. Adapun populasi dengan jumlah 44 karyawan Pada PT. Bank Negara Indonesia (Persero) Tbk. Kantor Cabang Bulukumba. Teknik pengambilan sampel yang digunakan ialah sampling jenuh dengan jumlah sampel sebanyak 44 responden yaitu keseluruhan populasi. Teknik pengumpulan data dilakukan dengan penyebaran kuesioner kepada karyawan. Teknik analisis data menggunakan regresi sederhana dengan bantuan software SPSS versi 25. Hasil Penelitian ini menunjukkan bahwa gaya kepemimpinan dan kualitas pelayanan memberikan pengaruh positif dan signifikan secara parsial pada kinerja karyawan pada PT. Bank Negara Indonesia (Persero) Tbk. Kantor Cabang Bulukumba. Secara simultan pengaruh gaya kepemimpinan dan kualitas pelayanan memberikan pengaruh yang signifikan terhadap kinerja karyawan pada PT. Bank Negara Indonesia (Persero) Tbk. Kantor Cabang Bulukumba.

Kata Kunci: Gaya Kepemimpinan, Kualitas Pelayanan, Kinerja Karyawan
IMPLEMENTATION OF COOPERATIVE STRATEGIES IN TEACHING ENGLISH TO JUNIOR HIGH SCHOOL
Authors: Putri Nur Afifah Nabila , Husein Ahmad , Damanik Emeliya Sukma Dara
Published: August 2024

Cooperative learning is a strategy that is often used in the teaching and learning process. In which the learning process is carried out in groups by students. In this case the students become more dominant than the teacher. The implementation of this strategy is also a reference to be more open between students with different genders, academic abilities, and different races. The methodology used is qualitative in writing. This paper contains learning strategies for students, especially junior high schools, where the implementation itself will provide variations for teachers in teaching and make students more creative in building their own knowledge.
STUDENTS' PERCEPTION OF USING EDPUZZLE IN LISTENING ASSESSMENT
Authors: Hamid Syifa Fadhilah
Published: August 2024

Edpuzzle is a useful website for teachers to find and edit online videos whether it is from YouTube, TED Talks, or Khan Academy, etc., to present it to their students in the classroom. In addition, Edpuzzle flourished to become one of the effective tools in listening assessment because studentâ€™s progress is easily tracked by the teacher and assigned videos are graded by Edpuzzle. This is a survey study which proposed to get an empirical data about studentsâ€™ perceptions of using Edpuzzle in listening assessment. The result of this study showed that studentsâ€™ perceptions of using Edpuzzle in listening assessment are positive. Using video in Edpuzzle perceived as an up-to-date and interesting way to be used in listening assessment based on 90% of the respondents, and they agreed that the content of the video provided in Edpuzzle as the listening assessment media was authentic since it is related to their daily life conversation. The use of Edpuzzle in listening assessment is perceived and received positively by the students of SMK Diponegoro 1 Jakarta who have ever used Edpuzzle in their listening assessment.
TEACHING ENGLISH FOR SPECIFIC PURPOSES (ESP): TEACHERS' ROLE AND THEIR CHALLENGES
Authors: Fitria Tira Nur
Published: August 2024

This study examines the role of the teacher and the challenges related to teaching English for Specific Purposes (ESP). This investigation was conducted in a library. The analysis indicates that teachers should have multiple responsibilities, such as managing/organizing learning, devising learning objectives, establishing a positive classroom environment, and evaluating student processes. The challenges that ESP teachers face in teaching ESP include the poor quality of teachers, the teachers' improper qualification and teaching methods, the absence of a theoretical framework for teaching ESP, a lack of knowledge about the field of study of their students, a lack of ESP training, the absence of a correct needs analysis, large classes, and learners with varying English proficiency levels. Students' motivation to learn English, demographic characteristics and demands of learning ESP, English proficiency, differences between languages, lack of vocabulary, reliance on the dictionary, and lack of skills in using the dictionary, especially for ESP terms. Among the environmental and other obstacles is the condition of the classroom, a lack of instructional materials, classes with an excessive number of students, and an excessive emphasis on the examination. In further research regarding curriculum and lesson plan comprehension.
LEARNING STYLE AND STUDENTS' ACADEMIC PERFORMANCE, IS THERE ANY RELATION?
Authors: J Syilvia Wenny , Dani Rian
Published: August 2024

When a pandemic hit the entire planet almost one year ago, every facet of the teaching and learning process changed. It is included in the learning styles of students. Some problems were observed during online learning, particularly for students at the University of Muhammadiyah Jambi. Some students seemed to not have a good preparation in studying. There were some distractions when the learning process occurred online at that time. For their task, they were late in submitting the task. Because of these concerns, it appeared that there was some dispute about how students truly learnt through online learning. The purpose of this study was to report statistics on the different types of learning styles utilized by students in their English online learning. Neil Fleming's The VARK Questionnaire was used to analyze the data. The qualitative descriptive method was applied in this study. This study's population consisted of first semester Management Department students in the academic year 2020. There were three different classes: R.B1, R.A7, and R.B3. The findings revealed that most students in this study used a kinesthetic learning style. Then came auditory learning, which was followed by reading and writing learning styles. The final was visual learning style. Nevertheless, there was not a significant correlation between academic performance and studentsâ€™ styles of learning based on the test results.
UNLOCKING YOUNG MINDS: THE POWER OF STORYTELLING IN TEACHING ENGLISH FOR YOUNG LEARNERS
Authors: Isnaniah Isnaniah , Ramalia Tenia , Viona Intan , Luthfiyandini Livia , Belina Tifana
Published: August 2024

This article will explain the power of storytelling in teaching English to young learners. Utilizing stories for scholastic purposes is a very useful system for teaching English to young learners. Storytelling is one of the main support systems for engaging young learners in the learning process. Storytelling has a good chance for young learners to discover the experience of real life and the language learning experience together. Through stories, young learners can gain various abilities and skills to develop themselves in English. Most young learners like stories; therefore, implementing English through stories gives strength to young learners.
Contribution of Image Processing in Chest X-Ray to Early Diagnosis in Radiological Evaluation of Lung Cancer
Authors: Bilgin Cahit , Asil Kıyasettin , Yördan Hilal Hazel , Kamanlı Ali Furkan , Uçar Muhammed Kürşad
Published: August 2024

This paper attempts to investigate the importance of image processing by chest X-rays (CXRs) in the early diagnosis of lung cancer. It analyzes the contributions of CXRs to the radiological assessment of lung cancer, discussing their benefits and flaws and proposing image processing methods for improving their performance. The research evaluates the performance of CXR versus other imaging methods including CT and focuses on the early diagnosis which is crucial for enhancing patients’ outcome Moreover, the paper delves into the latest progress in image technology and shows how it is used in improving the accuracy of chest radiographs in the diagnosis of lung cancer.
Hastanede Meydana Gelen İş Kazalarının İncelenmesi: Erzurum Şehir Hastanesi Örneği
Authors: Yıldırım Nilüfer , Bebek Selda
Published: August 2024

Düşme, iğne batması ve kesici-delici alet yaralanması sağlık çalışanları açısından önemlilik arz eden mesleksel risklerdendir. Bu çalışmanı amacı bir şehir hastanesi sağlık hizmetleri çalışanlarında kaydedilen, gerçekleşmiş kazaların, retrospektif olarak değerlendirilmesidir. Bu amaç ile hastane iş sağlığı güvenliği biriminin 2020-2023 yılları arasındaki kaza bildirim inceleme formları retrospektif olarak incelenmiştir. Bu tarihlerde iş sağlığı güvenliği birimine başvuran 138 bireyin kaza bildirim inceleme formundan veriler elde edilmiştir. Araştırmaya dahil edilen bireylerin 43 (%31.1)’ü temizlik personeli, 28 (%20.3)’i hemşire, 26 (%18.9)’sı işçidir. En fazla yaralanmaların olduğu kaza türü düşme (n=45, %32,6) ve kesilerdir (n=24, %17,4). En sık kaza nedenleri dikkatsizlik (n=91, %65,9), hızlı çalışma (n=16, %11,6), kaygan zemindir (n=12, %8,7). Kaza geçirenlerin tümü (n=138, %100) iş sağlığı güvenliği eğitimi almıştır. Sonuç olarak hastanelerde iş kazalarının analiz edilmesi, iş kazalarının nedenlerinin belirlenmesi, iyi bir güvenlik algısı oluşturma ve güvenlik performansını geliştirmek için oldukça önem arz etmektedir.
Ritual Nyera pada Mesin Kapal bagi Masyarakat Etnis Bajo di Desa Banu-Banua Jaya Kecamatan Kulisusu Kabupaten Buton Utara
Authors: Said Taufiq , La Ando La Ando , Ali Basri La Ode , Marhini La Ode
Published: August 2024

This research aims to analyze the importance of the Nyera Ritual on Ship Engines for the Bajo Ethnic Community and the meaning of the Nyera ritual in the Bajo ethnic community in Banu-Banua Jaya Village, Kulisusu District, North Buton Regency. The research method for collecting data was carried out using observation, interviews and documentation techniques. Using Edward B Tylor's theoretical basis, the technique for determining informants uses the purposive technique. Data were analyzed using data collection techniques, data reduction, data presentation and drawing conclusions. The results of this research show that the importance of the Nyera ritual consists of 5 types: 1.) Purification, 2.) Protection/Safety, 3.) Preserve, 4.) Fortune, 5). Friendship. The meaning in the Nyera ritual has 3 types of meaning: 1.) The meaning of materials such as water, incense, chicken, 2.) The meaning of the Nyera Ritual process, namely reciting prayers on water, the meaning of bathing a chicken, the meaning of reciting prayers on a knife, the meaning of wiping chicken blood on each side of the machine. 3.) The meaning of the final stage of reading prayers on the machine so that all wishes are carried out. The Nyera Ritual can be fulfilled by the Almighty and the meaning of giving syndikka money so that the person giving the syndikka money has good fortune.
Makna Tuturan Mowindahako (Pelamaran) Suku Moronene di Desa Tontonuhu Kecamatan Kontununu Kabupaten Bombana
Authors: Wilda Wilda , Niampe La , Suraya Rahmat Sewa
Published: August 2024

This study aims to determine and describe the meaning of speech in the Mowindahako (proposal) stages of Moronene tribal marriage in Tontonunu Village, Tontonunu District, Bombana Regency. This study uses a qualitative research type, namely research whose procedures produce descriptive data in the form of written or spoken words from traditional leaders (Tolea). Data collection techniques in the study used observation, interview, and documentation methods. The research analysis used a qualitative descriptive method. The results of the study show that the meaning of the Mowindahako (proposal) tradition speech of the Moronene tribe in Tontonunu Village can be seen in several stages, namely: the Kohala stage, the first Mowindahako (Proposal) stage, the second Mowindahako (Proposal) stage, the Moduduhi stage, and the Mompokontodo stage.
Ritual Pengobatan Maduai Kaka’ pada Suku Bajo di Desa Langara Bajo Kecamatan Wawonii Barat Kabupaten Konawe Kepulauan
Authors: Firmayanti Firmayanti , Syahrun Syahrun , Suraya Rahmat Sewa
Published: August 2024

The Maduai Kaka' Treatment Ritual is a ritual performed by the Bajo Tribe Community in Langara Bajo Village, West Wawonii District, Konawe Islands Regency. Inheritance pattern of the Maduai Kaka' Medicine Ritual in Langara Bajo Village, West Wawonii District, Konawe Islands Regency. The research method used in this research is descriptive qualitative. Data collection was carried out by observation, interview and documentation techniques. The technique of determining informants used purposive techniques, the data were analyzed using data collection techniques, data reduction, data presentation, and drawing conclusions.The results showed that the process of carrying out the Maduai Kaka' Treatment Ritual consisted of several stages, (1) the stage of disease diagnosis, this stage was the stage of examining the disease, (2) the stage of preparing tools and materials, (3) the stage of preparing the preparation of tools and materials this is the stage of preparing the offerings, (4) the stage of carrying out the treatment ritual, finally (5) the final stage of the treatment process. The function of the Maduai Kaka Treatment Ritual for the Bajo tribe in Langara Bajo Village, West Wawonii District, Konawe Islands Regency, namely (1) to maintain traditional ritual patterns (2) for treatment and (3) to reduce expenses. The pattern of inheritance in the Madua Kaka's Treatment Ritual is obtained through traditional leaders, namely sandro/shaman who leads the maduai kaka' treatment ritual, the type of inheritance of Madua Kaka' is enculturation and socialization.
Implementasi Support Vector Machine untuk Analisis Sentimen Aplikasi “Mpstore - Super App UMKM”
Authors: Afandi Rizki Baehtiar , Nurdiansyah Titis Fajar , Ramadhani Aimee Natya , Sari Anggraini Puspita
Published: August 2024

Arus revolusi digital semakin deras, menjadikan teknologi sebagai katalis utama yang mengubah berbagai aspek kehidupan, termasuk sektor usaha UMKM. MPStore, sebuah Aplikasi inovatif yang dikembangkan oleh PT. Mitra Pedagang Indonesia Tbk, dirancang untuk memberdayakan pelaku UMKM dalam pengelolaan penjualan, pembelian, pencarian produk, layanan pengguna, dan proses pembayaran. Aplikasi ini menyediakan platform yang efisien untuk menjalankan bisnis, memperluas cakupan pasar, dan meningkatkan daya saing UMKM di era kompetisi global. Penelitian ini bertujuan untuk mengeksplorasi ulasan pengguna terhadap aplikasi MPStore - SuperApp UMKM yang dikembangkan oleh PT. Mitra Pedagang Indonesia Tbk melalui analisis sentimen, sehingga aplikasi tersebut dapat ditingkatkan berdasarkan masukan pengguna. Tahapan penelitian ini dimulai dari pengumpulan data, data cleaning, labeling data menjadi positif dan negatif, pembobotan TF-IDF, membagi data latih dan data uji dengan perbandingan 80:20, dan klasifikasi menggunakan algoritma Support Vector Machine. Hasil penelitian menunjukkan bahwa algoritma SVM memberikan performa yang sangat baik dalam klasifikasi sentimen, dengan akurasi keseluruhan sebesar 90%. Model ini mampu mengidentifikasi sentimen negatif dengan precision sebesar 0.78, recall sebesar 0.59, dan f1-score sebesar 0.67. Sementara itu, untuk sentimen positif, model ini mencapai precision sebesar 0.92, recall sebesar 0.97, dan f1-score sebesar 0.94. Penelitian ini juga memberikan rekomendasi peningkatan fitur pada aplikasi MPStore berdasarkan analisis sentimen yang dilakukan, sehingga dapat meningkatkan kepuasan dan pengalaman pengguna secara keseluruhan. Implementasi dari hasil penelitian ini diharapkan dapat memberikan kontribusi nyata dalam pengembangan teknologi yang mendukung pertumbuhan UMKM di Indonesia.
Visualisasi Potensi Sektor Perekonomian Kota Kediri Menggunakan Metode Shiftshare
Authors: Nurfarida Ellya , Sukya Fadelis , Nugroho Benni Agung , Aullia Fikha Rizky
Published: August 2024

Kota Kediri merupakan Kota berkembang dalam sektor industri, pariwisata, dan hiburan. Hal ini didukung dengan adanya pembangunan Bandara Dhaha Kediri, yang menyebabkan calon investor tertarik berinvestasi. Permasalahan muncul ketika usaha investor tersebut tidak diimbangi dengan ketersediaan data pendukung investasi oleh pemerintah Kota Kediri. Salah satu data pendukung investasi Kota Kediri adalah pengelompokan sektor unggulan dan non unggulan Kota Kediri. Dimana hingga saat ini data perkembangan sektor unggulan maupun non unggulan Kota Kediri hanya tersedia di Badan Pusat Statistik dan disajikan dalam bentuk tabel saja. Sehingga investor mengalami kesulitan dalam menganalisis perkembangan sektor bidikan.  Website dalam bentuk visualisasi dari tahun ke tahun perlu dikembangkan guna menunjang investor dalam menilai tingkat keberhasilan usahanya. Pengembangan aplikasi yang dapat menampilkan sektor unggulan dan non unggulan berbasis web dalam bentuk grafik akan memudahkan investor dalam menganalisis sektor yang diminati. Pengembangan aplikasi website dengan menggunakan framework Laravel menghasilkan visualisasi dalam bentuk diagram batang pada data PDRB Jawa Timur dan Kota Kediri, dan visualisasi dalam bentuk kuadran untuk pengelompokan sektor menggunakan metode shiftshare.
Promosi Kesehatan dengan Film Cerita Pendek tentang Aktivitas Fisik pada Anak Usia Sekolah di Panti Asuhan Ummi Ikhlas Kota Jambi
Authors: Razi Pahrur , Iksarudin Iksarudin , Surayah Surayah
Published: August 2024

The most common causes of death in Indonesia are non-communicable diseases such as stroke, chronic kidney disease, diabetes mellitus, and hypertension. Lack of physical activity will have the potential to cause non-communicable diseases. Intensive health education efforts are needed with various innovative uses of IT to improve PHBS, especially physical activity such as through short story films. This PKM aims to increase perceptions and motivation to do physical activity and test the effectiveness of community service interventions through health promotion with short story films about physical activity. The implementation method is to carry out pre and post-tests through data collection from primary data obtained from questionnaires and observation formats. This PKM will be carried out in May-June 2023 with 80 participants at the Ummi Ikhlas Jambi Orphanage, involving students in data collection. The results increased the perception and motivation to carry out physical activity in school-age children at the Ummi Ikhlas Orphanage, Jambi City, from 25% (pretest) to 100% (posttest). It is recommended to increase it regularly to 2 times a week every morning on Wednesdays and Fridays, doing gymnastics at the Ummi Ikhlas Jambi Orphanage.
Modifikasi Pemberian Tawas Berupa Larutan untuk Penurunan Kekeruhan Air di Desa Sungai Rangas Hambuku
Authors: Khair Abdul , Noraida Noraida
Published: August 2024

As many as 89.3% of people in Sungai Rangas Hambuku Village still use river water for daily purposes. Turbidity measurements in 2021 amounted to 56 Nephelometric Turbidity Units (NTU) and in 2023 amounted to 53 NTU. This turbidity value has exceeded the maximum level allowed for water for hygiene and sanitation purposes of <3 NTU. Training on how to reduce the level of turbidity using alum has been provided in 2021, but the community has difficulty applying alum in a solid dosage form. The purpose of this activity is to train participants in administering alum to water taken from the river with modifications in the form of a solution preparation. The implementation method is pre-test, provision of training materials and demonstrations, post-test, and follow-up on the application of alum application to reduce water turbidity. Activity location in Sungai Rangas Village The duration of the activity is 6 months. The target number is 50 housewives.  The results of the activity showed that participants had increased their knowledge from a score of 41 to 76 to 71 to 100, participants were able to carry out the practice of making a 2% alum solution preparation, participants were able to carry out the practice of reducing the level of water turbidity using alum solution preparation, and participants were able to apply the results of the training in their respective homes.
Pelayanan Kesehatan pada Lansia di Panti Sosial Tresna Werdha Madago Tentena
Authors: Agusrianto Agusrianto , Langitan Rosamey Elleke , Manggasa Dafrosia Darmi Manggasa , Suharto Dewi Nurviana , Ndama Metrys , Rantesigi Nirva , Parwata Ni Made Ridla Nilasanti , Hermanto Raden Bagus Bambang
Published: August 2024

Elderly individuals generally undergo various physical and health changes. They tend to be more susceptible to various chronic diseases, such as diabetes, hypertension, arthritis, and neurological disorders like dementia. Therefore, they require specialized care and ongoing monitoring. These efforts can help prevent diseases and enhance the quality of life for the elderly. Some of the main issues frequently faced by elderly individuals living in nursing homes are related to their health, including chronic diseases, mental disorders, and physical decline. The goal of this community service is to make a tangible contribution to improving elderly healthcare services through collaboration between the community service team and the staff of the independent living facility.The target of this community service team is 63 elderly individuals residing at PTSW Madago Tentena. The results of the community service activities indicate that most of the elderly residents at PTSW suffer from chronic diseases, including 13 individuals (20.64%) with diabetes mellitus, 41 (65.1%) with hypertension, 2 (3.2%) with severe cognitive impairment, and 5 (7.9%) with mild cognitive impairment. The health status is categorized as severe for 8 (12%), moderate for 30 (48%), and mild for 25 (40%). Therefore, the outcomes of this community service can serve as a reference for the nursing home staff to strive for improved health among the elderly and collaborate with other institutions to provide healthcare services in the facility.
Penerapan Senam Lansia Terhadap Kebugaran Jasmani di Desa Tete B Kecamatan Ampana Tete
Authors: Ndama Metrys , Langitan Rosamey Elleke , Supetran I Wayan , Khaira Nuswatul
Published: August 2024

Aging is a natural process that occurs in every individual throughout his life. One aspect that is closely related to aging is a change in physical fitness. Physical fitness is an important factor that affects the quality of life and well-being of the elderly. The growth rate of the elderly population by the year 2030 is estimated to be greater than the age of adolescents and young people by about 2.1 billion, compared to 2 billion worldwide. The goal of the community dedication is to improve the quality of life of the elderly by improving their physical fitness through the exercise of the elders, because exercising can increase muscle strength and flexibility and thus help them to live a healthier and more fit life in their communities. The activity was carried out in the village of Tete B. Ampana Tete was followed by 15 people, along with 5 people. The results of the activity can be described as follows: all the seniors who attended the gym can follow well and walk smoothly, with no obstacles or injuries. There are three elderly people who have arthritis and hearing loss and are so slow to follow instructions, but they can finish the activity well. The conclusion that can be drawn is that the more frequently doing gymnastics with the elderly, the better the older's health.
The essential role of dual-energy x-ray absorptiometry in the prediction of subclinical cardiovascular disease
Authors: Yang Sisi , Chen Qin , Fan Yang , Zhang Cuntai , Cao Ming
Published: August 2024

Subclinical cardiovascular disease (Sub-CVD) is an early stage of cardiovascular disease and is often asymptomatic. Risk factors, including hypertension, diabetes, obesity, and lifestyle, significantly affect Sub-CVD. Progress in imaging technology has facilitated the timely identification of disease phenotypes and risk categorization. The critical function of dual-energy x-ray absorptiometry (DXA) in predicting Sub-CVD was the subject of this research. Initially used to evaluate bone mineral density, DXA has now evolved into an indispensable tool for assessing body composition, which is a pivotal determinant in estimating cardiovascular risk. DXA offers precise measurements of body fat, lean muscle mass, bone density, and abdominal aortic calcification, rendering it an essential tool for Sub-CVD evaluation. This study examined the efficacy of DXA in integrating various risk factors into a comprehensive assessment and how the application of machine learning could enhance the early discovery and control of cardiovascular risks. DXA exhibits distinct advantages and constraints compared to alternative imaging modalities such as ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography. This review advocates DXA incorporation into cardiovascular health assessments, emphasizing its crucial role in the early identification and management of Sub-CVD.
The impact of new infrastructure development on urban total factor carbon productivity-empirical evidence based on Chinese cities
Authors: Liu Yang , Wang Yu , Yan Bing , Zhang Hengshuo
Published: August 2024

Digital technology plays a vital role in driving toward a zero-carbon future. This paper explores whether new infrastructure, serving as carriers for digital technology, contributes to carbon reduction and efficiency gains in cities. Drawing on panel data from 280 Chinese cities spanning 2011 to 2019, we establish a theoretical analytical framework to investigate how new infrastructure influences urban carbon performance through the perspectives of influence, threshold, and spatial spillover effects. The study reveals that new infrastructures development has a contributing effect on the total factor carbon productivity of cities, with consistent results across various testing methods. Additionally, the threshold effect test suggests that the dual threshold of regional energy consumption influences the enhancing effect of new infrastructure on total factor carbon productivity, exhibiting nonlinear characteristics. Furthermore, the spatial spillover effect test suggests that new infrastructure construction accelerates the local carbon emission performance, while having a positive spillover effect on neighboring cities. This study provides innovative ideas and experiences from China for the global realization of simultaneous promotion of digital economy development and energy conservation and emission reduction.
Predictive biomarkers of mortality in patients with severe COVID-19 hospitalized in intensive care unit
Authors: dos Santos Medeiros Sandrelli Meridiana de Fátima Ramos , Sousa Lino Bruna Maria Nepomuceno , Perez Vinícius Pietta , Sousa Eduardo Sérgio Soares , Campana Eloiza Helena , Miyajima Fábio , Carvalho-Silva Wlisses Henrique Veloso , Dejani Naiara Naiana , de Sousa Fernandes Matheus Santos , Yagin Fatma Hilal , Al-Hashem Fahaid , Elkholi Safaa M. , Alyami Hanan , Souto Fabrício Oliveira
Published: August 2024

Objectives

This study was performed to identify predictive markers of worse outcomes in patients with severe COVID-19 in an intensive care unit.

Methods

Sixty patients with severe COVID-19, hospitalized in the Intensive Care Unit (ICU) between March and July 2021, were stratified into two groups according to the outcome survivors and non-survivors. After admission to the ICU, blood samples were collected directly for biomarker analysis. Routine hematological and biochemical biomarkers, as well as serum levels of cytokines, chemokines, and immunoglobulins, were investigated.

Results

Lymphopenia, neutrophilia, and thrombocytopenia were more pronounced in non-surviving patients, while the levels of CRP, AST, creatinine, ferritin, AST, troponin I, urea, magnesium, and potassium were higher in the non-surviving group than the survival group. In addition, serum levels of IL-10, CCL2, CXCL9, and CXCL10 were significantly increased in patients who did not survive. These changes in the biomarkers evaluated were associated with increased mortality in patients with severe COVID-19.

Conclusion

The present study confirmed and expanded the validity of laboratory biomarkers as indicators of mortality in severe COVID-19.
How low can you go? Exploring impact of drones on haul out behaviour of harbour - and grey seals
Authors: Stepien Emilie Nicoline , Khan Jibran , Galatius Anders , Teilmann Jonas
Published: August 2024

Introduction

Drones, or Unmanned Aerial Vehicles (UAVs), have emerged as valuable tools for wildlife monitoring, offering potentially non-intrusive observations in challenging terrains like marine ecosystems. Despite their potential, widespread use is impeded by regulatory constraints, especially in protected areas.

Methods

This study aims to assess the impact of varying flight altitudes and flight approaches of two commercial drones on the behaviour of harbour seals (Phoca vitulina) and grey seals (Halichoerus grypus) and compare to existing findings for marine mammals. We conducted a comparative analysis of the response to flight altitude from 70 m gradually descending to 10 m and two different flight approaches between the DJI Phantom 4Pro and the Autel EVO II RTK drones in the Danish part of the Wadden Sea.

Results

We found varying responses, where species-specific sensitivity and environmental conditions appeared to influence the behavioural reactions of the seals. Our results reveal that seal reactions to drones are complex and depend on several factors, such as flight altitude, drone model, received noise levels, approach, weather conditions, the animals’ annual cycle, and geographic location.

Discussion

The outcomes hold significance for refining regulatory policies governing drone flights in protected marine environments, balancing conservation efforts with technological advancements in wildlife monitoring and ensuring undisturbed observations of seals.
Longitudinal antinuclear antibody titers in systemic lupus erythematosus and other rheumatic diseases
Authors: Littlejohn Emily A. , Kong Lingxuan , Wang Lu , Somers Emily C.
Published: August 2024

Introduction

Antinuclear antibodies (ANAs) are a key feature of systemic lupus erythematosus (SLE) and marker of subclinical autoimmunity. Little is known about longitudinal ANA titers in individuals from the general population or in predicting clinical disease course in persons with rheumatic diseases.

Methods

We performed an exploratory analysis from an academic health system between 1999 and 2020 to assess intra-individual variation in ANAs longitudinally in persons with SLE, other ANA-associated rheumatic diseases, and ANA+ controls without rheumatic disease.

Results

Persons with SLE had a higher odds of positive ANA compared to those with other ANA-associated rheumatic diseases [OR 2.10, 95% CI (1.82, 2.43)] controlling for time and demographics (age, sex, race, ethnicity). Compared to ANA+ controls, the ANA titer strength was significantly higher for both the ANA-associated rheumatic disease (0.33 log units higher) and SLE groups (0.42 log units higher) controlling for demographics and time (p < 0.001 for both). Over time from the first positive ANA, titer strength significantly decreased for all three groups, with average monthly decreases ranging between 0.001 to 0.004 log titer units (p ≤ 0.001 for all).

Conclusion

Based on this analysis of electronic health data spanning two decades, ANA titers may be more dynamic than previously accepted in patients with SLE and ANA-associated rheumatic diseases, with average titers tending to be higher in early disease and decreasing over time.
High phenanthrene degrading efficiency by different microbial compositions construction
Authors: Zhou Guoyan , Qiao Hongtao , Liu Yandong , Yu Xiongsheng , Niu Xiang
Published: August 2024

Microbial remediation has become the most promising technical means for the remediation of polycyclic aromatic hydrocarbons (PAHs) non-point source contaminated soil due to its low cost of treatment, complete degradation of pollutants, and in-situ remediation. In this study, in order to demonstrate the phenanthrene degrading microbial diversity, phenanthrene was chosen as the representative of PAHs and strains capable of degrading phenanthrene were isolated and screened from the sedimentation sludge and the bottom sludge of oil tank trucks, and high throughput sequencing was used to check the dominant strains with a good degrading effect on phenanthrene. Results showed even more than 50% of phenanthrene was degraded in all samples, the composition of PAH-degrading bacteria was diverse, and different environments constructed different functional microbial groups, which resulted in the microbial adapting to the diversity of the environment. Finally, a series of bacterial species with phenanthrene-degrading functions such as Achromobacter, Pseudomonas, Pseudochelatococcus, Bosea was enriched after nine transferring process. Overall, our study offers value information for the enrichment of functional degrading microbes of phenanthrene or other pollutants that more concern should be paid in not only the degradation rate, but also the diversity variation of microbial community composition.
Antimetastatic and antitumor activities of oncolytic NDV AMHA1 in a 3D culture model of breast cancer
Authors: Al-Shammari Ahmed Majeed , Salman Marwa Ibrahim
Published: August 2024

Introduction

Newcastle disease virus (NDV) AMHA1 is capable of killing cancer cells by direct replication or induction of apoptosis alongside other pathways. In this study, we report the potent antimetastatic and anticancer activities of NDV AMHA1 in a 3D spheroid model of breast cancer metastasis.

Methods

we used two breast cancer cell lines AMJ13 and MCF7 in our metastasis model system.

Results

First, we showed that NDV AMHA1 can infect and kill breast cancer cells in proliferating adherent cells and tumor spheroids using different virus doses and studying virus replication kinetics. We showed that NDV can infect and spread within the spheroids that represent metastasis before and after reattachment. Furthermore, we evaluated the ability of NDV to induce apoptosis in cancer spheroids and by virus tracking showed that NDV infection is essential for the elimination of these metastasis spheroids.

Discussion

The mechanism by which NDV induces cell killing in the metastasis model is the induction of caspase-3 and P21 and inhibition of Ki67 in cancer cells, but not in normal cells. In conclusion, these results indicate that NDV AMHA1 has the ability to kill breast cancer metastases in suspension or attached, and this is a novel finding of NDV AMHA1 being a possibly efficient therapy against human metastatic breast cancer.
A comprehensive review of electrophysiological techniques in amyotrophic lateral sclerosis research
Authors: Ren Keyuan , Wang Qinglong , Jiang Douglas , Liu Ethan , Alsmaan Julie , Jiang Rui , Rutkove Seward B. , Tian Feng
Published: August 2024

Amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, is characterized by progressive motor neuron degeneration, leading to widespread weakness and respiratory failure. While a variety of mechanisms have been proposed as causes of this disease, a full understanding remains elusive. Electrophysiological alterations, including increased motor axon excitability, likely play an important role in disease progression. There remains a critical need for non-animal disease models that can integrate electrophysiological tools to better understand underlying mechanisms, track disease progression, and evaluate potential therapeutic interventions. This review explores the integration of electrophysiological technologies with ALS disease models. It covers cellular and clinical electrophysiological tools and their applications in ALS research. Additionally, we examine conventional animal models and highlight advancements in humanized models and 3D organoid technologies. By bridging the gap between these models, we aim to enhance our understanding of ALS pathogenesis and facilitate the development of new therapeutic strategies.
Nonlinear analysis of neuronal firing modulated by sinusoidal stimulation at axons in rat hippocampus
Authors: Yuan Yue , Ye Xiangyu , Cui Jian , Zhang Junyang , Wang Zhaoxiang
Published: August 2024

Introduction

Electrical stimulation of the brain has shown promising prospects in treating various brain diseases. Although biphasic pulse stimulation remains the predominant clinical approach, there has been increasing interest in exploring alternative stimulation waveforms, such as sinusoidal stimulation, to improve the effectiveness of brain stimulation and to expand its application to a wider range of brain disorders. Despite this growing attention, the effects of sinusoidal stimulation on neurons, especially on their nonlinear firing characteristics, remains unclear.

Methods

To address the question, 50 Hz sinusoidal stimulation was applied on Schaffer collaterals of the rat hippocampal CA1 region in vivo. Single unit activity of both pyramidal cells and interneurons in the downstream CA1 region was recorded and analyzed. Two fractal indexes, namely the Fano factor and Hurst exponent, were used to evaluate changes in the long-range correlations, a manifestation of nonlinear dynamics, in spike sequences of neuronal firing.

Results

The results demonstrate that sinusoidal electrical stimulation increased the firing rates of both pyramidal cells and interneurons, as well as altered their firing to stimulation-related patterns. Importantly, the sinusoidal stimulation increased, rather than decreased the scaling exponents of both Fano factor and Hurst exponent, indicating an increase in the long-range correlations of both pyramidal cells and interneurons.

Discussion

The results firstly reported that periodic sinusoidal stimulation without long-range correlations can increase the long-range correlations of neurons in the downstream post-synaptic area. These results provide new nonlinear mechanisms of brain sinusoidal stimulation and facilitate the development of new stimulation modes.
Identification of symptomatic carotid artery plaque: a predictive model combining angiography with optical coherence tomography
Authors: Zhuo Jun , Wang Lin , Li Ruolin , Li Zhiyuan , Zhang Junhu , Xu Yunjian
Published: August 2024

Objective

Symptomatic carotid artery disease is indicative of an elevated likelihood of experiencing a subsequent stroke, with the morphology of plaque and its specific features being closely linked to the risk of stroke occurrence. Our study based on the characteristics of carotid plaque assessed by optical coherence tomography (OCT), the plaque morphology evaluated by digital subtraction angiography (DSA) and clinical laboratory indicators were combined, develop a combined predictive model to identify symptomatic carotid plaque.

Methods

Patients diagnosed with carotid atherosclerotic stenosis who underwent whole-brain DSA and OCT examination at the Affiliated Hospital of Jining Medical University from January 2021 to November 2023 were evaluated. Clinical features, as well as DSA and OCT plaque characteristics, were analyzed for differences between symptomatic and asymptomatic cohorts. An analysis of logistic regression was carried out to identify factors associated with the presence of symptomatic carotid plaque. A multivariate binary logistic regression equation was established with the odds ratio (OR) serving as the risk assessment parameter. The receiver operating characteristic curve was utilized to assess the combined predictive model and independent influencing factors.

Results

A total of 52 patients were included in the study (symptomatic: 44.2%, asymptomatic: 55.8%). Symptomatic carotid stenosis was significantly linked to four main factors: low-density lipoprotein-cholesterol >3.36 mmol/L [OR, 6.400; 95% confidence interval (CI), 1.067–38.402; p = 0.042], irregular plaque (OR, 6.054; 95% CI, 1.016–36.083; p = 0.048), ruptured plaque (OR, 6.077; 95% CI, 1.046–35.298; p = 0.048), and thrombus (OR, 6.773; 95% CI, 1.194–38.433; p = 0.044). The combined predictive model generated using four indicators showed good discrimination (Area Under Curve, 0.924; 95% CI, 0.815–0. 979). The p value was <0.05 with 78.26% sensitivity and 93.10% specificity.

Conclusion

OCT is valuable in evaluating the plaque characteristics of carotid atherosclerotic stenosis. The combined predictive model comprising low-density lipoprotein-cholesterol >3.36 mmol/L, irregular plaque, ruptured plaque, and thrombus could help in the detection of symptomatic carotid plaque. Further research conducted on additional independent cohorts is necessary to confirm the clinical significance of the predictive model for symptomatic carotid plaque.
Comprehensive analysis of systemic, metabolic, and molecular changes following prospective change to low-carbohydrate diet in adults with type 2 diabetes mellitus in India
Authors: Bhandarkar Nikhil Suresh , Shetty K. Bhujang , Shetty Naren , Shetty Keerthy , Kiran Anupama , Pindipapanahalli Narendra , Shetty Rohit , Ghosh Arkasubhra
Published: August 2024

Purpose

South Asians, especially Indians, face higher diabetes-related risks despite lower body mass index (BMI) compared with the White population. Limited research connects low-carbohydrate high-fat (LCHF)/ketogenic diets to metabolic changes in this group. Systematic studies are needed to assess the long-term effects of the diet, such as ocular health.

Method

In this prospective, observational study, 465 candidates aged 25–75 years with type 2 diabetes included with institutional ethics approval. A total of 119 subjects were included in the final study assessment based on the availability of pathophysiological reports, tears, and blood samples collected at baseline, 3rd, and 6th months. Serum and tear samples were analyzed by an enzyme-linked lectinsorbent assay, to examine secreted soluble protein biomarkers, such as IL-1β (interleukin 1 Beta), IL-6 (interleukin 6), IL-10 (interleukin 10), IL-17A (interleukin 17A), MMP-9 (matrix metalloproteinase 9), ICAM-1 (intercellular adhesion molecule 1), VEGF-A (vascular endothelial growth factor A), and TNF-α (tumor necrosis factor-alpha). A Wilcoxon test was performed for paired samples. Spearman’s correlation was applied to test the strength and direction of the association between tear biomarkers and HbA1c. p-value of < 0.05 was considered significant.

Results

After a 3- and 6-month LCHF intervention, fasting blood sugar decreased by 10% (Δ: −14 mg/dL; p < 0.0001) and 7% (Δ: −8 mg/dL; p < 0.0001), respectively. Glycated hemoglobin A1c levels decreased by 13% (Δ: −1%; p < 0.0001) and 9% (Δ: −0.6%; p < 0.0001). Triglycerides reduced by 22% (Δ: −27 mg/dL; p < 0.0001) and 14% (Δ: −19 mg/dL; p < 0.0001). Total cholesterol reduced by 5.4% (Δ: −10.5 mg/dL; p < 0.003) and 4% (Δ: −7 mg/dL; p < 0.03), while low-density lipoprotein decreased by 10% (Δ: −11.5 mg/dL; p < 0.003) and 9% (Δ: −11 mg/dL; p < 0.002). High-density lipoprotein increased by 11% (Δ: 5 mg/dL; p < 0.0001) and 17% (Δ: 8 mg/dL; p < 0.0001). At the first follow-up, tear proteins such as ICAM-1, IL-17A, and TNF-α decreased by 30% (Δ: −2,739 pg/mL; p < 0.01), 22% (Δ: −4.5 pg/mL; p < 0.02), and 34% (Δ: −0.9 pg/mL; p < 0.002), respectively. At the second follow-up, IL-1β and TNF-α reduced by 41% (Δ: −2.4 pg/mL; p < 0.05) and 34% (Δ: −0.67 pg/mL; p < 0.02). Spearman’s correlation between HbA1c and tear analytes was not statistically significant.

Conclusion

The LCHF diet reduces the risk of hyperglycemia and dyslipidemia. Changes in tear fluid protein profiles were observed, but identifying promising candidate biomarkers requires validation in a larger cohort.