bluuebunny/crossref_metadata_2025 huggingface dataset:
Absolute Agreement Between Subjective Hand Squeeze and Objective Handgrip Strength in Adults
Authors: Kieser Jacob , Langford Matthew , Stover Emily , Tomkinson Grant R. , Clark Brian C. , Cawthon Peggy M. , McGrath Ryan
Published: January 2025

Kieser, J, Langford, M, Stover, E, Tomkinson, GR, Clark, BC, Cawthon, PM, and McGrath, R. Absolute agreement between subjective hand squeeze and objective handgrip strength in adults. J Strength Cond Res XX(X): 000–000, 2024—Despite handgrip strength (HGS) being considered a convenient muscle strength assessment, HGS lacks routine measurement in sports medicine and healthcare settings because barriers such as time and lack of instrumentation may exist. Alternatives to circumvent these barriers should be sought. This study examined the absolute agreement of a subjective estimate of strength capacity on objectively measured HGS in adults aged 18–84 years. We also evaluated the test-retest reliability of an electronic handgrip dynamometer as a secondary purpose. There were 4 trained interviewers (i.e., assessors) who were assigned completely at random to subject laboratory visits occurring on 2 separate days. Trained interviewers carefully positioned their fingers into the hand of each subject before asking them to squeeze their fingers with maximal effort, and interviewers estimated each subject's HGS. An electronic handgrip dynamometer objectively measured HGS. Intraclass correlation coefficients (ICCs) were used for the analyses. The analytic sample included 100 subjects (age: 48.0 ± 20.2 years; 61% women). Poor agreement between mean objective HGS and averaged subjective hand squeeze was observed (ICC: 0.47; 95% confidence interval [CI]: 0.40–0.53). However, there was moderate agreement between dynamometer-derived maximal HGS and the most accurate HGS estimate (ICC: 0.75; CI: 0.65–0.86). An excellent test-retest reliability was found for mean (ICC: 0.97; CI: 0.95–0.98) and maximal HGS with the electronic dynamometer (ICC: 0.97; CI: 0.96–0.98). Trained interviewers performing subjective hand squeezes can approximate objective HGS with adequate accuracy, which could be useful when time and handgrip dynamometry access are lacking. Expanded interviewer training and testing may help with implementation.
The Role of Speed, Change of Direction, and Momentum by Position and Starting Status in Division 1 Collegiate Football Players
Authors: Mann J. Bryan , Cowley Nicholas , Weakley Jonathon
Published: January 2025

Mann, JB, Cowley, N, and Weakley, J. The role of speed, change of direction, and momentum by position and starting status in Division 1 collegiate football players. J Strength Cond Res XX(X): 000–000, 2024—This study (a) investigated differences between big, mid, and skill positions in sprint and change of direction times and momentum; (b) compared starting and nonstarting athletes; and (c) investigated whether thresholds can be developed to distinguish between starting and nonstarting Division 1 collegiate football athletes. Data from 496 collegiate football players who completed the 40-yard dash, pro-agility, and L drill were analyzed. Momentum was calculated using body mass and the average velocity during each test. To assess differences between positions and starters and nonstarters, data were analyzed using linear mixed models with effect size ±95% confidence intervals. Receiver operating characteristic (ROC) curves were generated to determine whether a cutoff value could be used to distinguish starters from nonstarters. Significant differences for both time and momentum were found between positional groups and starters and nonstarters for all tests in all positions. Starting skill position players tended to have greater differences in sprint or change of direction times and starting big players had greater sprint momentum. However, it should be noted that all ROC curves demonstrated relatively poor predictive value. Collectively, these findings demonstrate that bigger, faster players are preferentially selected in collegiate Division 1 football and there may be value in coaches collecting and assessing different outcome measures (e.g., sprint times and sprint momentum) depending on the positional group of the player. Finally, it should be acknowledged that setting binary thresholds to guide selection decisions is ill-advised and that speed, change of direction, and momentum are only one piece of the performance puzzle.
The Association Between Body Composition and Performance on Military Fitness Tests
Authors: Feeney Kimberly A. , Melton Bridget F. , Ryan Greg A. , Bland Helen W. , Butler Cody R.
Published: January 2025

Feeney, KA, Melton, BF, Ryan, GA, Bland, HW, and Butler, CR. The association between body composition and performance on military fitness tests. J Strength Cond Res XX(X): 000–000, 2024—Body composition and physical testing are important considerations for military personnel. However, limited research exists on the potential relationship between these 2 factors. The purpose of this retrospective cohort study was to examine the correlations between several body composition measures and performance on the components of 2 separate fitness tests in Air Force special warfare candidates. Within the cohort of candidates, 1,036 completed body composition testing, 1,002 completed a calisthenic-based fitness test, and 562 completed a fitness test designed to mimic occupational tasks. Analysis of Pearson correlations indicated that the calisthenic-based test weakly favored candidates with lower body mass and body fat levels on the lower end of that found within the cohort studied, while a higher score on the occupational-based test was linked to higher body mass index (BMI) and skeletal muscle mass (SMM) and lower absolute and relative body fat levels. Individual components of the occupational-based test favored different body composition relationships. A large negative association was seen between the farmer's carry time and SMM (r = −0.53) and a moderate negative association between farmer's carry time and body mass (r = −0.46), p < 0.01. The weight lifted during 3-RM deadlift demonstrated moderate positive associations with body mass (r = 0.49), BMI (r = 0.50), and SMM (r = 0.49), p < 0.01. These results suggest that individuals in physically active military roles should maximize SMM while managing body fat levels.
Proces kształtowania polskich bibliotek publicznych na przestrzeni wieków. Historia Biblioteki Uniwersyteckiej w Warszawie
Authors:   Biblioteka Uniwersytecka w Warszawie, Gańko Agnieszka
Published: January 2025

The aim of the paper is to present the changing role of public libraries on the example of the University of Warsaw Library. The 18th century was particularly important for the history of public libraries. Then their intensive development as publicly accessible institutions took place. The next century brought the strengthening of the idea of public libraries as centers of culture and education. At the same time, it was a difficult time for libraries in Poland. As a result of the partitions, they were deprived of the protection of the Polish state, and their activities focused on protecting the national heritage. In such circumstances, in 1817 the University of Warsaw Library was established. In fact, from the beginning of its existence, it combined the functions of a university library and a public library, although since then the detailed mode and main function of its activity have changed many times. Nowadays, electronic resources and Internet sources are gaining more and more popularity among library users, and libraries are treated more as a space for personal work than as a place of access to collections.
Transformacje bibliotek akademickich w kontekście sojuszy Uniwersytetów Europejskich
Authors:   Biblioteka Uniwersytecka w Warszawie, Nalewajska Lilianna
Published: January 2025

The Lisbon Declaration and the Bologna Process have laid the groundwork for change in the field of European higher education. A further step to improve the quality of education is the establishment of European Universities in the form of partnerships, multi-level cooperation between universities in the areas of teaching and research. The transformation is affecting all university units, including academic libraries. How is the transformation of academic libraries related to the functioning of universities in an alliance manifesting itself? Are libraries making use of this opportunity for their own development, or does cooperation with foreign libraries place an additional burden on them? How are Polish academic libraries coping with the increasing cooperation of partner European Universities? The article presents, among other things, the results of a survey on the transformation of academic libraries in the context of European Universities alliances conducted by the author among Polish academic libraries of universities belonging to partner alliances.
Transformacja usług bibliotecznych
Authors:   Instytut Solidarności i Męstwa im. Witolda Pileckiego (Instytut Pileckiego), Stępień Justyna
Published: January 2025

Transformation of Library Services The COVID pandemic, dynamic changes in society, mobility – all these factors caused libraries to modify their approach to users. Thanks to the introduction of online registration, home delivery, book dispensers, drop boxes and other solutions, cultural institutions were able to meet readers’ expectations. The presentation will be devoted to innovations that were launched in the years 2020–2023 in selected libraries from among university, voivodeship, public and school libraries. The institutions will indicate which solutions were temporary and which are to be permanent. The users’ expectations about these new services will also be discussed. A survey will be conducted for the purposes of the presentation.
ИЗУЧЕНИЕ IN VITRO ВЛИЯНИЯ ГОМОЦИСТЕИНОВОГО ЛИНКЕРА НА ПОВЕДЕНИЕ КОНЪЮГАТОВ СЫВОРОТОЧНОГО АЛЬБУМИНА ЧЕЛОВЕКА И МОНОМЕТИЛАУРИСТАТИНА F
Authors: ВАН М. , РОГАЛЕВА В.И. , ПОПОВА Т.В. , ЗАХАРОВА О.Д. , ГОДОВИКОВА Т.С. , СИЛЬНИКОВ В.Н.
Published: January 2025

Синтезированы флуоресцентные конъюгаты сывороточного альбумина человека и цитостатического препарата - монометилауристатина F, имеющего расщепляемый пептидный линкер ValCit. В синтезе использованы стратегии прямого присоединения терапевтического пептида к альбумину и присоединение с помощью N-трифторацетилгомоцистеинового линкера. Методом конфокальной микроскопии установлено, что конъюгат, содержащий гомоцистеиновый линкер, эффективно накапливается в цитоплазме опухолевых клеток линии MCF-7, в то время как конъюгат, полученный прямым присоединением пептида к белку, накапливается преимущественно на поверхности клеток. Исследования конъюгатов in vitro на линиях клеток MCF-7 и T98G выявили проявление большей цитотоксичности монометилауристатина F в отношении раковых клеток линий MCF-7 и T98G после его присоединения к альбумину. Установлено, что конъюгат, содержащий гомоцистеиновый линкер, проявлял большую цитотоксичность в сравнении с конъюгатом, полученным прямым присоединением монометилауристатина Fк альбумину, несмотря на меньшую нагрузку белка терапевтическим пептидом.

Fluorescent conjugates of human serum albumin and a maleimide derivative of monomethyl auristatin F containing the cleavable peptide linker ValCit were synthesised. Strategies included the direct attachment of the peptide to the albumin structure and the attachment of the peptide through the N-trifluoroacetylhomocysteine linker. Confocal microscopy showed that the conjugate with the homocysteine linker effectively accumulated in the cytoplasm of the MCF-7 tumor cells, whereas the conjugate without the linker displayed predominant surface accumulation. In vitro studies demonstrated that the monomethyl auristatin F conjugate exhibited enhanced cytotoxicity against MCF-7 and T98G cancer cells after its attachment to albumin. The homocysteine-containing conjugate showed superior cytotoxicity compared to the conjugate without the linker despite the lower peptide load.
ОЦЕНКА ПАРАМЕТРОВ ТЕРМИЧЕСКОЙ ДЕСТРУКЦИИ НАНОКОМПОЗИТОВ ТЕЛЛУРИДА ВИСМУТА НА ОСНОВЕ ПОЛИАНИЛИНА
Authors: ЖМУРОВА А.В. , ЛОГИНОВ Б.А. , ЗВЕРЕВА М.В.
Published: January 2025

Исследовано влияние наночастиц теллурида висмута (Bi2Te3) и многостенных углеродных нанотрубок (МУНТ) на термическую деструкцию и морфологию поверхности их нанокомпозитов с полианилином (ПАНИ) при различном содержании нанофазы (Bi2Te3 - 7.3 мас. %, МУНТ - 1.5 мас. %), впервые полученных с использованием механохимического подхода. На основе данных синхронного термического анализа и сканирующей туннельной микроскопии показано, что введение неорганической нанофазы ключевым образом влияет на термические свойства синтезированных композитов ПАНИ-Bi2Te3 и ПАНИ-Bi2Te3-МУНТ, а также на их структуру. При этом термостойкость нанокомпозитов и исходной полимерной матрицы, оцениваемая по температуре начала второй стадии потери массы образца, совпадает и составляет 166 °C.

The effect of bismuth telluride (Bi2Te3) nanoparticles and multi-walled carbon nanotubes (MWCNTs) on thermal destruction and surface morphology of their nanocomposites with polyaniline (PANI) at different nanophase contents (Bi2Te3 - 7.3 wt%, MWCNTs - 1.5 wt%), obtained for the first time using the mechanochemical approach, has been investigated. It is shown on the basis of the data obtained by synchronous thermal analysis and scanning tunnelling microscopy that the introduction of inorganic nanophase has a key effect on the thermal properties of the synthesised composites PANI-Bi2Te3 and PANI-Bi2Te3-MWCNTs, as well as on their structure. The thermal stability of nanocomposites and the initial polymeric matrix, assessed from the temperature of the onset of the second mass loss stage, is the same and equal to 166 °C.
СОПОСТАВИТЕЛЬНОЕ ИССЛЕДОВАНИЕ ХИМИКО-ТЕХНОЛОГИЧЕСКИХ СВОЙСТВ И МОЛЕКУЛЯРНОГО СТРОЕНИЯ УГЛЕЙ МЕСТОРОЖДЕНИЙ РОССИИ И МОНГОЛИИ КАК СЫРЬЯ ДЛЯ ТЕХНОЛОГИЧЕСКОЙ ПЕРЕРАБОТКИ
Authors: КУЗНЕЦОВ П.Н. , АВИД Б. , ОБУХОВА А.В. , КУЗНЕЦОВА Л.И. , КОСИЦЫНА С.С. , ЛЫРЩИКОВ С.Ю. , ПУРЕВСУРЕН Б. , ЗАОСТРОВСКИЙ А.Н. , ИСМАГИЛОВ З.Р.
Published: January 2025

Представлены результаты химического, технического и петрографического анализа образцов углей разной стадии углефикации, отобранных на различных месторождениях России и Монголии. С применением метода 13C ЯМР-спектроскопии в твердом теле с использованием техники кросс-поляризации и вращения образца под магическим углом (CP/MAS 13C ЯМР) изучены особенности молекулярного строения углеродного каркаса органической массы, установлены существенные различия в строении поликонденсированных ароматических структур, сделана оценка в соотношении пери- и катаконденсированных ароматических ядер в зависимости от степени углефикации. Выполнен корреляционный анализ, установлены взаимосвязи между различными химико-технологическими параметрами углей и показателями их молекулярного строения. Наиболее тесная связь существует между степенью ароматичности углей, долей периконденсированных структур, выходом летучих веществ и коэффициентом отражения витринита. Установленные особенности молекулярного строения органической массы углей и выявленные регрессионные зависимости могут служить физико-химической основой выбора углей для получения поликонденсированных ароматических веществ как сырья для производства углеродных материалов.

The results of chemical, proximate and petrographic analysis of coal samples at different coalification stages from various deposits in Russia and Mongolia are presented. Features of the molecular structure of the carbon framework in the organic matter were studied by the solid-phase 13C NMR spectroscopy using the cross polarization with magic angle spinning (CP/MAS). Significant differences in the structure of polycondensed aromatic nuclei were revealed, and the ratio between the pericondensed and catacondensed cycles depending on the degree of coalification was assessed. Correlation analysis has been carried out and the relationships between various chemical technological parameters of coals and the indicators of their molecular structure were established. The strongest relationships have been revealed between the aromaticity factor of coals, the fraction of carbon in pericondensed structures, the yield of volatile substances and the reflectance of vitrinite. The identified features of the molecular structure of the organic coal matter and the obtained regression dependences can serve as the physicochemical basis when selecting coals for obtaining polycondensed aromatic substances for the production of carbon materials.
ЭВРИСТИЧЕСКИЙ ПОТЕНЦИАЛ ЗАКОНА ОТРИЦАНИЯ ОТРИЦАНИЯ В КОНТЕКСТЕ ЕГО ЗНАЧЕНИЯ ДЛЯ ПОНИМАНИЯ РАЗВИТИЯ НАУЧНОГО ЗНАНИЯ
Authors: КИРИЧЕК А.В. , ХОДИКОВА Н.А.
Published: January 2025

В статье исследуются эвристические возможности закона отрицания отрицания и связанных с ним категорий для раскрытия закономерностей роста научного знания. На материале истории естествознания показано, что борьба альтернативных концепций может быть представлена сквозь призму этого закона в виде завершенных циклов перехода от исходного тезиса через несколько антитезисов к итоговому синтезу, который впоследствии может стать тезисом в рамках нового познавательного цикла. На основе проведенного анализа авторы формулируют рекомендации методологического характера, адресованные широкому кругу исследователей и нацеленные на повышение результативности любой творческой деятельности.

The article studies the heuristic capabilities of the law of the negation of negation and related categories for revealing the patterns of the growth of scientific knowledge. Based on the history of natural science, it is shown that the struggle of alternative concepts can be presented in the light of this law as completed cycles of transition from the initial thesis through several antitheses to the final synthesis, which can subsequently become a thesis within the framework of a new cognitive cycle. According to the conducted analysis, the authors formulate methodological recommendations addressed to a wide range of researchers and aimed at increasing the effectiveness of any creative activity.
Електронна структура та можливість експери-ментального моніторингу фазового складу кристалів полівініліденфториду (PVDF)
Authors: Baranchykov Z. , Hizhnyi Yu. , Makarenko O. , Nedilko S.G.
Published: January 2025

Органiчний полiмер полiвiнiлiденфториду (PVDF) є перспективним та комерцiйно привабливим матерiалом для сучасних потреб нанотехнологiй i мiкроелектронiки та бiомедицини. Детектування фазового складу сумiшей PVDF є важливою технологiчною задачею. В роботi представлено результати ab initio розрахункiв електронної зонної структури трьох найбiльш розповсюджених фаз кристалiв полiвiнiлiденфториду, α-, β- та γ-PVDF. Одержано та проаналiзовано структуру одноелектронних зон, парцiальних густин електронних станiв, просторових розподiлiв електронної гу-стини, спектрiв дiелекричних сталих, комплексного показника заломлення, поглинання та вiдбивання, спектри iнфрачервоного поглинання, комбiнацiйного розсiювання та рентґенограми α-, β- та γ-фаз PVDF. Проведений аналiз результатiв розрахункiв електронної структури дозволив зробити ряд висновкiв щодо особливостей формування електронних та оптичних властивостей α-, β- та γ-фаз кристала PVDF, а також зробити деякi передбачення щодо можливостi експериментального монiторингу фазового складу цiєї сполуки. Встановлено, що детектування одночасної наявностi β- та α-(або γ-) фази в зразках кристалiв PVDF може бути ефективно здiйснене методами спектроскопiї вiдбивання в дiапазонi вакуумного ультрафiолету, iнфрачервоного поглинання, комбiнацiйного розсiювання, рентґенофазного аналiзу. Видiлити ж наявнiсть α-фази на фонi γ-фази PVDF зазначеними методами буде практично неможливо.
Investigation of Content Validity and Exploratory Factor Analysis of Students’ Economic Behavior Measure
Authors: Narmaditya Bagus Shandy , Sahid Sheerad , Hussin Muhammad
Published: January 2025

Economic behavior has attracted scholars in the last decade, and past studies measured this construct partially from consumptive perspectives or entrepreneurial behavior (Mulyani et al., 2018). Therefore, this study aims to develop a new and valid measurement of students’ economic behavior and investigate its content validity using an exploratory factor analysis (EFA). The content validity is provided using an experts’ assessment method with a 4-point evaluation form. At the same time, the exploratory factor analysis is performed using SPSS. This study involved content validity assessment for each item (I-CVI) for the entire scale (S-CVI/Ave). Based on the analysis of the questionnaire scale, it can be concluded that the content validity check using I-CVI, S-CVI/Ave, and S-CVI/UA is all satisfactory except for item SEB20, which was subsequently dropped. On the other hand, the results of EFA indicated that two more items did not meet the thresholds and, thus, were excluded. Therefore, developing instruments to measure students’ economic behavior is prominent in dealing with digital changes, preventing consumptive behavior, and enhancing economic well-being.
Investigation of Construct Validity of The Indonesian Version of The Financial Wellness Questionnaire
Authors: Renanita Theda , Hidayat Rahmat , Santoso Agung
Published: January 2025

Developing a financial wellness questionnaire in Indonesia is necessary to evaluate household financial situation. However, there has been a scarcity of research that adapts and tests the psychometric properties of the financial wellness questionnaire in Indonesia. The purpose of the current study was to evaluate the psychometric properties of the Indonesian version of Joo’s Financial Wellness Questionnaire. Data was collected using an online survey consisting of 388 participants (25-60 years). The results provided two evidences of the validity of the Indonesian version of the Financial Wellness Questionnaire based on the scale’s internal structure. Firstly, the structure of relationships between items in the questionnaire fits the theoretical model of financial wellness, which includes objective and subjective measurements. Furthermore, the structure of relationships between items in the subjective measure fits the theoretical model of the subjective measure of financial wellness, which comprises aspects of subjective perception, financial behavior, and financial satisfaction. Based on the evaluation of the Multiple Indicator Multiple Cause (MIMIC) model fitted, we also identified the effects of gender, education, and socio-economic status (SES) on some of the subjective financial wellness indicators. Therefore, the questionnaire should consider the aforementioned variables in interpreting the questionnaire scores.
Seed germination and seedling emergence of Gundelia tournefortii L. in response to some environmental factors
Authors: Nosratti Iraj , Felegari Hamze , Ghobadi Mohammad Eghbal
Published: January 2025

Gundelia tournefortii has long been considered a valuable medicinal and edible plant in the Mediterranean areas. Seeds are the main means through which G. tournefortii can propagate in space and in time. The aim of this experiment was to evaluate the impact of environmental factors on seed germination of this wild medical and food plant. In this study, we investigated the germination and emergence responses of seeds of G. tournefortii collected from Kamyaran and Sonqor in western Iran to the environmental factors of light, temperature, salt stress, water potential, and sowing depth. The results showed that the optimal temperature for germination was 20°C, with a maximum germination percentage of about 70% for both populations. In general, the two populations responded to the tested factor(s) similarly. Light was not required for germination of G. tournefortii. The species was tolerant to water stress (germinating more than 50% under water potential up to -1.0 MPa), while sensitive to salt stress. More than 50% of the seedlings of G. tournefortii were able to emerge from depths more than 12 cm. According to the results, rain-fed fields located in the western parts of Iran are suitable for the planting of G. tournefortii.
Developing English Language Teachers’ Action Research Competencies Through an Exploratory Action Research Project
Authors: Pinninti Lakshmana Rao
Published: January 2025

This article reports the impact of an exploratory action research (EAR) project on developing teachers’ action research competencies. Through various face-to-face and online activities, the project facilitated four English language teachers to conduct EAR in their teaching contexts. Qualitative data were collected through reflective journals and WhatsApp group chats. Data reveal that each participating teacher critically reflected on the teaching context, selected a research question, collected and interpreted evidence, designed and evaluated an action, and disseminated their research. The findings imply that teachers’ participation in EAR can develop their action-research competencies and ability to integrate teaching and research for their continuing professional development.
Enhancing Intercultural Skills Through a COIL Experience
Authors: Marsee Mickey , Pineda Hoyos Jorge Eduardo
Published: January 2025

This paper describes a case study of instructional strategies employed in a collaborative online international learning experience between students from Colombia and the US to increase their understanding of cultural tolerance. The study aimed to examine student perception of their intercultural skills development, particularly in recognizing both cultural similarities and differences, as previous research suggests that students struggle with identifying differences, focusing only on similarities in exchanges. Data were collected from transcriptions of student reflection recordings and their final presentations and were analyzed using the intercultural competence dimensions and subdimensions framework. The findings suggest that participants developed cultural awareness of differences, openness, and tolerance of their own and their partners’ cultures and increased their teamwork skills.
Positionings and Tensions Among Discursive Acts in a Colombian EFL Classroom: Interpretations of Linguistic Identity
Authors: Silva-Alfonso Katherin
Published: January 2025

This article presents a qualitative study exploring how eleventh-grade EFL students in a Colombian private school construct their linguistic identities through discursive positioning practices. In the context of language standardization, students negotiate their identities amid tensions between institutional frameworks and actual discursive practices. Drawing on discourse analysis, positioning theory, conversational analysis, and speech acts theory, the study reveals the struggle between an imagined ideal of English proficiency and learners’ lived experiences. Findings highlight how institutional discourses influence students’ perceptions of themselves and others, fostering both conformity and resistance. The implications emphasize the need for socially responsible language education practices that challenge hegemonic ideologies and empower learners to redefine their linguistic identities.
Desenvolvimento e validação de método analítico por CLAE para determinação simultânea de atorvastatina, losartana e metformina em formulações farmacêuticas magistrais
Authors: Galana Gerlin Mirella Carla , Mazon Cardoso Teófilo Fernando , Gomes de Souza João Batista , de Moraes Baroni Adriano Cesar , Serrou do Amaral Marcos , Kassab Najla
Published: January 2025

Objetivos: Desenvolver e validar um método analítico para a análise simultânea de atorvastatina (ATO), losartana (LOS) e metformina (MTF) em formulações farmacêuticas magistrais por CLAE. Método: O método foi desenvolvido empregando o cromatógrafo a líquido modelo Dionex® Ultimate 3000, acoplado ao detector de arranjo de diodos (DAD) e a validação se deu conforme compêndios de validação internacional e nacional. Os seguintes parâmetros foram analisados: linearidade, precisão, exatidão, robustez, seletividade, LD e LQ. A separação cromatográfica foi realizada na coluna Sigma-Aldrich® C18, fase móvel MeOH:H2 O (78:22 v/v), pH 3,0 e vazão de 0,3 mL·min-1, modo isocrático. As detecções foram realizadas nos comprimentos de onda de 225 nm (LOS), 236 nm (MTF) e 246 nm (ATO). Resultados: O método foi linear, com coeficientes de correlação linear (r)> 0,99 para todos os fármacos, preciso (DPR entre medidas < 2 %), exato (recuperação entre 98-102 %). As variações propostas no estudo de robustez não tiveram influência significativa nos resultados, exceto a coluna cromatográfica. O método foi seletivo, pois os excipientes não interferiram nas análises. A sensibilidade do método foi demonstrada através da determinação teórica dos LD e LQ. Conclusão: Os resultados obtidos sugerem que o método cromatográfico desenvolvido e validado nessa pesquisa poderá ser empregado nas análises de rotina dos laboratórios de controle de qualidade de medicamentos contendo esses fármacos de forma isolada ou combinados em formulações farmacêuticas de uso oral.
Dispersiones sólidas de solubilidad mejorada fabricadas en mezcladores de alto corte: una oportunidad para la industria farmacéutica local mexicana
Authors: Garcia-Radilla Abigail , Ortiz-Reynoso Mariana , Santillán-Benítez Jonnathan G. , Alcantara-Fierro Edna T.
Published: January 2025

Introducción: los fármacos clase II representan un alto porcentaje de las moléculas en fase de investigación biomédica. Este grupo atrajo la investigación en los últimos años, ya que su baja solubilidad acuosa condiciona su absorción in vivo, lo que plantea un reto para la tecnología farmacéutica. El diseño de dispersiones sólidas (SD) es una técnica que ha tenido éxito y se basa en la dispersión del fármaco en un acarreador polimérico, promoviendo el estado amorfo del primero. Uno de los métodos de obtención de SD es el de fusión, que se puede llevar a cabo en equipos sofisticados, pero los mezcladores de alto corte (HSM) también son una alternativa para obtener granulados por fusión. Objetivo: el objetivo de este trabajo es revisar si han sido reportados procesos de granulación por fusión utilizado HSM para la fabricación de SD y analizar las fortalezas, debilidades, oportunidades y amenazas de este equipo en dicho proceso. Método: en una metodología de revisión documental, se preseleccionaron 90 publicaciones de las bases de datos PubMed, ScienceDirect y Google Scholar de los últimos 20 años, de las cuales ocho describen el uso del método de granulación por fusión en HSM. Resultados: como resultados se vio que el 100% de estos casos reportó mayor solubilidad y velocidad de disolución que el fármaco puro. Se concluye que las empresas locales que cuentan con HSM tienen el potencial para poner en marcha procesos de fabricación de SD exitosos en HSM, con la ventaja de no hacer una inversión adicional.
Reporte de caso: Hepatozoon sp. en un canino en Bogotá
Authors: Cañon-Cocunubo E.
Published: January 2025

Este reporte de caso describe un diagnóstico de hepatozoonosis en Bogotá en una hembra canina mestiza de un año tratada exitosamente con dipropionato de imidocarb. La paciente presentó inicialmente tos persistente, organomegalia, condición corporal baja y palidez de las mucosas. Tras realizar un hemograma, se detectó anemia normocítica normocrómica, trombocitopenia e hiperglobulinemia, lo que sugirió hemoparasitismo como primer diagnóstico diferencial. La confirmación de Hepatozoon sp. mediante PCR permitió iniciar un tratamiento específico con dipropionato de imidocarb, complementado con atropina y doxiciclina dirigida contra posibles coinfecciones. El seguimiento clínico y hematológico mostró una notable mejoría, con resolución de la anemia y la trombocitopenia. Este caso resalta la importancia de incluir Hepatozoon canis en los diagnósticos diferenciales en zonas de altitud superior a los 2.600 m s. n. m., particularmente en caninos provenientes de refugios, debido al riesgo de subdiagnóstico en áreas no endémicas y la posibilidad de transmisión vertical. La aparición de hepatozoonosis en Bogotá sugiere un riesgo emergente para la región, lo que subraya la necesidad de divulgar este caso junto con los métodos diagnósticos y terapéuticos empleados. En este contexto, la disponibilidad de herramientas moleculares, como la PCR, es crucial para un diagnóstico preciso y un manejo adecuado de esta infección en zonas de reciente incidencia.
Tratamiento endodóntico en fractura dentaria con exposición pulpar de cuarto premolar superior derecho en un canino: reporte de caso.
Authors: López–Paredes S. , Alves Da Costa J. , Paredes-Gómez B. A. , De Jesús J. , De Marchi Furuya D.
Published: January 2025

Las fracturas dentales son un conjunto de lesiones específicas que afectan al diente y/o a sus estructuras de soporte. En la odontología veterinaria, la fractura de la corona dental con exposición de la cámara pulpar es una de las lesiones endodónticas más comunes. Aunque la extracción dental es uno de los tratamientos que se puede utilizar para estos casos, el tratamiento del canal radicular es un procedimiento más especializado y menos invasivo, por lo cual es una alternativa viable para fracturas supragingivales horizontales del diente. Este trabajo reporta el caso de un canino macho de raza Cavalier King Charles Spaniel, castrado y de 5 años, evaluado y tratado por el equipo veterinario Amico Dental en Brasil. Durante el examen clínico, se observó gingivitis leve y una fractura dental que afectaba el esmalte, la dentina y la pulpa en el diente 108. El examen radiográfico mostró indicios de lisis ósea periapical, lo que sugirió una posible infección localizada. Este caso subraya la importancia de las fracturas dentales y presenta el tratamiento endodóntico mediante la restauración radicular con la técnica de obturación del canal pulpar como una opción frente a la extracción dental en casos de exposición pulpar.
Prevalencia del síndrome de burnout en médicos familiares que laboran en Colombia y factores asociados
Authors: Ramirez Rios Jorge Luis , Pardo Baez Juan Felipe , Fuentes Estepa Cesar Julian , Toledo Arenas Jose Daniel
Published: January 2025

Objetivo Determinar la prevalencia y los factores asociados a la presencia de síndrome de burnout en los médicos familiares en ejercicio en Colombia en el año 2021.
Métodos Se desarrolló un estudio transversal analítico en el cual, en un momento dado en el tiempo, se tomaron datos de una serie de sujetos (profesionales en Medicina Familiar) y se realizó en el mismo momento una encuesta y el cuestionario de Maslach. Se describió esta población. A continuación, se usó el cuestionario citado previamente, se dividió el grupo en personas con el síndrome de burnout y sin dicho síndrome, y con esta información se procedió a construir tablas de 2x2, donde se obtuvieron los respectivos OR para cada factor de riesgo o protector. Se obtuvo una prevalencia de punto. Para hacer estimación de parámetros se calcularon los intervalos de confianza y se probó cada una de las hipótesis con una p de 0,05.
Resultados Se analizó un total de 206 encuestas. Se encontró una prevalencia de síndrome de burnout de 48% (IC 95% 47,54-48,46), la cual abarcó una muestra que comprende 33 ciudades diferentes en Colombia, y se halló como factor de riesgo estadísticamente significativo el encontrarse trabajando con la modalidad de contrato por orden de prestación de servicios, con un OR de 2,11 (IC 95% 1,19-3,72 p=0,007).
Conclusión Este estudio muestra que uno de cada dos médicos familiares en Colombia presenta síndrome de burnout, lo que refleja posibles dificultades en su labor que requieren ser evaluadas e intervenidas para mitigar esta condición.
Migrations in Latin America: the corridor to the American dream is a public health problem
Authors: Camargo Assis Francisco , Lopez Mejia Yeimi , Salim Mattar Ameth , Mattar Salim
Published: January 2025

Introduction Migrant movements have tripled, and it is evident throughout the Americas. On the way to North America, people come from South America, the Caribbean, mainly Haiti, Cuba, Asia, and Africa. People migrate for work, study, humanitarian situations, poverty, violence in their territories, lifestyle change, or family reunification.
Objetive The aim of this study is to assess the impact of most frequent infectious conditions of the population exposed to migratory movement through the Américas.
Materials and Methods The present review focuses on the leading infectious diseases migrants acquired during the arduous journey through the tropical areas. Official migration web sides, journals, and scientific journals were used to get information.
Results Some infectious diseases have reemerged in transit countries used by migrants, and the increase in migratory phenomena, triggered cases of HIV/AIDS, Tuberculosis, arbovirosis, Malaria, and hepatitis, among others.
Conclusions Migrants suffer infectious diseases as they pass the countries to the USA; besides, they suffer violence and even sexual assault. The receiving countries should establish public policies to regularize the access of migrants to health services, which include preventive programs and easily accessible vaccination plans. Some of the pathologies suffered by migrants are preventable, although there are groups of populations in extreme social conditions and with compromised nutritional status. The need to establish a primary medical care center to apply an innovative border and transnational protocols for infectious diseases for migrant populations is highlighted.
Índices antropométricos, actividad física y patrones alimentarios en estudiantes de nutrición y dietética de Colombia
Authors: Sora Gutiérrez Maritza , Deossa Restrepo Gloria Cecilia , Santa Cristian David , González Difariney
Published: January 2025

Objetivo Analizar los cambios en la composición corporal (Índice de masa corporal e Índice cintura/talla), la actividad física y los patrones alimentarios en estudiantes de nutrición y dietética de universidades colombianas, entre los años 2017 y 2018.
Materiales y Métodos Estudio descriptivo longitudinal, con datos secundarios correspondientes al estudio multicéntrico de estudiantes de nutrición y dietética de universidades de Colombia y México. Muestra de 228 estudiantes de universidades colombianas, entre 18 y 31 años, evaluadas en dos momentos, con diferencia de un año. Incluyó variables sociodemográficas, antropométricas, de actividad física y consumo de alimentos. Se aplicó estadística descriptiva y análisis inferencial. Los patrones alimentarios se determinaron mediante análisis factorial confirmatorio.
Resultados El índice de masa corporal y el índice cintura/talla presentaron diferencias estadísticamente significativas entre las evaluaciones 1 y 2 (p<0,05), con aumento del riesgo cardiovascular, sin diferencias significativas en la actividad física entre las dos evaluaciones (p>0,05). Se determinaron 3 patrones dietéticos: a) cardioprotectores, b) altos en azúcar y c) altos en grasa, sin cambios entre evaluaciones.
Conclusión El presente estudio evidenció aspectos críticos en la alimentación, la composición corporal y la actividad física de las estudiantes, que se mantienen o empeoran en el tiempo, a pesar del avance en su formación académica en el área de alimentos, dietética y salud.
Vigilancia epidemiológica de agentes bacterianos causantes de enfermedades transmitidas por alimentos en el norte de Chile, 2016-2022
Authors: Ortiz Álvarez Mirko , Santander Pulgar Edgardo , Allendes Siles Alejandra , Vicencio Ahumada Marcelo
Published: January 2025

Objetivo Describir las bacterias notificadas en matrices relacionadas con las enfermedades transmitidas por alimentos (ETAs) en la región de Tarapacá (Chile).
Materiales y Métodos Se llevó a cabo un estudio descriptivo del total de las notificaciones informadas por el sistema vigilancia en Tarapacá, desde el año 2016 hasta el 2022. Las variables analizadas fueron bacteria causal, alimento involucrado, programa de vigilancia y distribución temporal de las bacterias notificadas durante dicho periodo.
Resultados Durante el periodo analizado se notificaron 184 cepas de diferentes bacterias (Salmonella spp, Staphylococcus aureus, Listeria monocytogenes, Vibrio parahaemolyticus, Vibrio cholerae y Bacillus cereus). Los productos cárnicos y los platos preparados, en conjunto con los productos de la pesca son los que contienen más detecciones bacterianas. El programa de vigilancia regional de alimentos ha notificado todas las bacterias mencionadas y es el que tiene mayores notificaciones, seguido de las importaciones. Se notificaron más bacterias en alimentos que en agua. El año 2019 fue el que tuvo un mayor número de bacterias notificadas (68 cepas). Salmonella spp y Staphylococcus aureus fueron las bacterias que se notificaron todos los años. Salmonella spp y Vibrio parahemolyticus fueron las que tuvieron un mayor número de notificaciones, con 34,8% y 22,8%, respectivamente.
Conclusión La información solicitada a través de transparencia activa a la Secretaría Regional Ministerial de Salud de Tarapacá y al Instituto de Salud Pública permitió identificar las bacterias con mayor ocurrencia y más frecuentes. También se logró identificar que los programas de vigilancia regional y de importaciones deben fortalecerse y que los productos cárnicos, en conjunto con los productos de la pesca, demandan mayor fiscalización.
Violencia obstétrica desde la percepción y vivencias de mujeres en labor de parto, Valledupar, Colombia
Authors: Corzo Contreras Margareth , Polo Payares Esther Patricia , Murgas Quintero María Cecilia , Hurtado Luján Luz Alba , Cuesta Morato Belkis Vanessa
Published: January 2025

La violencia obstétrica ha sido definida desde legislaturas de Latinoamérica como todas las acciones u omisiones que el personal de salud ejerce sobre el cuerpo y los procesos reproductivos de las mujeres, consistentes en un trato deshumanizado, abuso de medicalización y patologización, que afecta su experiencia de parto.
Objetivo Visibilizar desde las voces de las mujeres su percepción de la vulneración de los derechos sexuales y reproductivos generados por la violencia obstétrica.
Metodología Estudio cualitativo, descriptivo exploratorio. Muestra intencional de 30 mujeres que cumplían los criterios de inclusión, usuarias de instituciones de salud de Valledupar, Colombia, entre 2020 y2021; se utilizó entrevista en profundidad y relatos orales, categorización teórica y emergente. Muestra con saturación, validación interna y externa por triangulación y consideración de aspectos éticos.
Resultados Las narrativas de las participantes dan cuenta de su percepción de las acciones que vulneran sus derechos, reflejada en expresiones que se interpretan a la luz de las recomendaciones de la Organización Mundial de la Salud (OMS), como el parto respetado, el abuso de medicalización y rutinas no recomendadas, que reflejan relaciones hegemónicas y no terapéuticas, silenciamiento e invasión de su corporalidad, así como riesgos para su salud y la de su hijo.
Conclusión La sumisión y falta de calidez experimentadas en un momento de vulnerabilidad de las mujeres, producen en su esfera psicológica la memoria de sus partos como unas experiencias negativas.
Narrativas de la conducta suicida en mujeres estudiantes de una universidad pública en México
Authors: Méndez Romero Nancy Araceli
Published: January 2025

Introducción La conducta suicida comprende diferentes fases: ideación, planeación e intento de suicidio. En México el suicidio representa la tercera y cuarta causa de muerte en mujeres de 10 a 14 y de 15 a 24 años, respectivamente.
Objetivo Analizar las experiencias de ideación e intento suicida de mujeres que cursan sus estudios en una universidad pública del estado de México (México).
Métodos Métodos Investigación cualitativa realizada de junio de 2023 a mayo de 2024. Se obtuvo una muestra intencional de cinco mujeres seleccionadas bajo determinados criterios: ser mayor de edad, tener un riesgo de suicidio de moderado a alto en la Escala de Riesgo Suicida Plutchik, haber recibido una orientación para el cuidado de la salud mental, estrategia utilizada para obtener las declaraciones personales sobre el comportamiento suicida. La información recolectada fue sistematizada en Atlas ti, se obtuvieron tres categorías las cuales fueron analizadas con enfoque de género en salud.
Resultados Se identificó que las participantes del estudio han intentado el suicidio alguna vez y que la ideación y el intento suicida ocurrieron desde etapas tempranas, lo cual les ha ocasionado un malestar psicoemocional persistente. Las experiencias sobre la conducta suicida están vinculadas a la exigencia de roles de género tradicionales, así como a vivir en entornos de violencia o carentes de apoyo.
Conclusiones La universidad requiere fortalecer actividades de acompañamiento académico y solidario, así como llevar a cabo acciones de prevención del suicidio, identificando condiciones de violencia u otras que afecten a mujeres estudiantes. Los casos en riesgo necesitan identificarse y derivarse a los servicios especializados.
Glucagon and insulin immunopositivity of mast cells in porcine gallbladder
Authors: Stefanov I. S , Stefanov S. I. , Gulubova M. V.
Published: January 2025

It is well known that mast cells produce and release biologically active substances such as histamine, heparin, proteases, leukotrienes, cytokines, chemokines and growth factors. According to the available scientific literature on that topic this is the first time when gallbladder mast cells were found to have a capacity to produce insulin and glucagon. We aimed to perform an immunohistochemical study to determine glucagon- and insulin-positive mast cell existence and distribution in the wall of porcine gallbladder. The collocalisation of glucagon and insulin immunopositivity with metachromasy allowed us to detect the presence of glucagon and insulin immunoreactive mast cells in the bottom, body and neck of gallbladder. In addition, an immunohistochemical detection of tryptase as a better marker for mast cells than toluidine blue dye was used to compare the number of mast cells to glucagon and insulin immunoreactive cells. The ability of mast cells to produce hormones was confirmed by the chromogranin A immunopositivity of the same cells. The highest mast cell density was registered in in all layers of gallbladder’s neck, followed by the body and bottom of gallbladder. In conclusion, we established histochemically and immunohistochemically the localisation and density of two new types of mast cells: glucagon and insulin positive mast cells.
Conflicting data and new ways of digitising Byzantine prosopography
Authors: Rózsa Márton
Published: January 2025

This paper aims to illustrate the abilities and practicability of digital prosopographical databases through the case of historical dates. Numerous historical databases were created in the last few decades, and they applied different models to record and store historical data in an effective way. Although the developers and researchers of these projects faced several problems due to a conflict between the characteristics of structured databases and the nature of historical evidence and historical studies. The paper compares the methodologies of two databases, PBW and RELEVEN through the cases of the death of John of Bari and Bisantius Guirdeliku. The primary sources provide conflicting dates of these events. Thus, the analysis can address the issues of interpretation and authority behind a piece of information.
Irish antiquity and ancient Greece: Standish O'Grady's History of Ireland
Authors: McAteer Michael
Published: January 2025

Published between 1878 and 1881, the three volumes of Standish O'Grady's History of Ireland comprise a narrative of Irish mythology, driven by the author's conviction that many of the ancient tales were rooted in actual history. Although not immediately felt, the impact of History of Ireland became long-lasting, a point of departure for an array of literary works treating Irish mythological topics during what came to be known as the Irish Literary Revival. This paper addresses History of Ireland from the perspective of O'Grady's background as a student of ancient Greek civilization. It considers the most important comparisons that he drew between Irish and Greek antiquity, including his contention that the seat of the High Kings of Ireland, Tara, was equivalent in symbolism to Mount Olympus in ancient Greece. The paper assesses the strengths, weaknesses and significance of O'Grady's case for considering Irish mythology as approximate to that of the Greeks.