bluuebunny/crossref_metadata_2025 huggingface dataset:
Stent strut ablation with rotational atherectomy device (Rotablator™) for restenosis treatment. Analysis and late follow-up
Authors: Rocha Débora , Guimarães Henrique , Barbosa Flávio , Morais Júnior Álvaro , Diniz Roosevelt , Gardenghi Giulliano
Published: October 2020

The widespread use of bare metal stents as from 1995 led to the appearance of a new entity called in-stent restenosis, and the severe concomitant calcification of the vessels is a challenge for the interventional cardiologist. In this scenario, rotational atherectomy has rised as a therapeutic rescue approach to manage this situation, using trephines to eliminate the underexpanded and non-expandable coronary stents. However, comprehensive data on the long-term efficacy or results of the procedures have not been published yet. We report a case of rotational atherectomy in stent restenosis, followed by percutaneous coronary intervention with implantation of a new stent to treat a calcified in-stent lesion.
الـمُسْتَدرِكُ عَلَى شِعْرِ ابْنِ حَـــرِيـْق البَلَنْسِي
Authors: عبد الله برهان صفاء
Published: October 2020

هذا استدراك على شعر ابن حريق البلنسي (ت 622هـ)، الذي جمعه للمرة الأولى الدكتور محمد بن شريفة قبل ربع قرن من الزمان، وكان له فضل التعريف بهذا الأديب الأندلسي الكبير وقتذاك، وتقديمه إلى المهتمين بالتراث العربي عامة، والباحثين في الشأن الأندلسي خاصة. فجاء هذا الاستدراك مكملا ومصححا لما قدمه ابن شريفة، ومضيفا إلى عمله السابق أبيات شعرية جديدة، لم يسبق نشرها في ذلك المجموع، وهو شأن طبيعي عند توافر الأدوات وإسعاد الوسائل التي يجود بها الزمان؛ بحسب ما يظهر للوجود من مخطوطات وما ينشر منها، حسبت في ضمن المفقودات لقرون من الزمن، ومنه ما يتعلق بموضوع هذا الاستدراك، فظهر لنا من شعر ابن حريق ما يدعو إلى الاستدراك؛ لتوضيح نبذة من ملامح ذلك الشعر.
اتخاذ القرار وعلاقته باتساق الذات لدى المشرفين الاختصاصيين
Authors: علي جاسم حياة
Published: October 2020

اتخاذ القرار لدى المشرفين الاختصاصين ، اتساق الذات لدى المشرفيين الاختصاصين العلاقة بين اتخاذ القرار واتساق الذات لدى المشرفيين الاختصاصين ، الفروق في العلاقة بين اتخاذ القرار واتساق الذات حسب الجنس (ذكر ، انثى)، الفروق في العلاقة بين اتخاذ القرار واتساق الذات حسب سنوات الخدمة لدى المشرفيين الاختصاصين.

         استخدمت الباحثة المنهج الوصفي ، وشملت عينة البحث من (100) مشرف ومشرفة ، تم اختيارهم بالطريقة العشوائية ذات التوزيع المتناسب بواقع (60) من الذكور (40) من الاناث.

تم التوصل الى النتائج التالية:

        ان المشرفين الاختصاصيين اندفاعيين في أتخاذ قراراتهم وغير مترددين باتخاذها ، يتمتع  المشرفين الاختصاصيين باتساق الذات ولابعاده الثلاثة ، استقلالية اتخاذ القرار الاندفاعي والمتردد عن اتساق الذات ، ولا توجد علاقه تفسر بينهما تفسير الاخر

       عدم وجود اختلاف في طبيعة العلاقة بين اتخاذ القرارات المتروية واتساق الذات اذا ما اختلف جنس المشرف، ان متخذي القرارات المتروية يرتبطون اكثر باتساق الذات كلما زادت سنوات الخدمة وينخفض عند المشرفين الاختصاصيين الجدد في العمل , كما لم تظهر النتائج وجود فروق حقيقية بين اتخاذ القرار المندفع والمتردد بسنوات الخدمة للمشرفين الاختصاصين.
ضوابط التفكير الصوتي عند الخليل في مقدِّمة كتاب العين
Authors: حازم عيدان جاسم الحديدي خالد
Published: October 2020

هذا البحث يسلِّط الضوءَ على الضوابط الصوتية التي اعتمدها الخليل بن أحمد الفراهيدي رحمه الله تعالى (ت 175هـ) في مقدِّمة كتابه العين من خلال جملة الأمور التي عرضها في تلك المقدِّمة، والتي تعدُّ مفتاحاً للوصول إلى المادة اللغوية داخله من جهة، وبيان الخصائص الصوتية للغة العربية من جهة أخرى. ورَسَم البحث تلك الضوابط على شكل نقاط عامة متضمِّنة ضوابطَ فرعيةً يجمعها قاسمٌ مشتركٌ في معالجتها للجوانب الصوتية الواردة في تلك المقدِّمة، وكلُ ذلك بالاعتماد على آرائِه وأفكاره التي بثَّها وهو يبيِّن منهجَه في الكتاب.
المقدمات الجاهلية بالأفواه العباسية
Authors: عبد الرحمن زايد إيناس
Published: October 2020

تعد المقدمة إنموذجا حياً لشعراء العصر الجاهلي فهي بنيه في قصائدهم التي تميزوا بها، وافتتاحية جوهرية لكل شاعر في قصيدته، وفي العصر العباسي أخذ من ينادي بفكرة التخلص من تلك المقدمات وتركها؛ لأنها لا تمت بأية صلة لعصرهم، لكن بعضهم افتتحوا قصائدهم العباسية بمقدمات شبيهه بمقدمات جاهلية، لذا ارتأيتُ بيان هذه الملامح الطلليه عند الشعراء العباسيين. وقد قسمتُ البحث بعد الملخص على مقدمة ومبحثين أوضحتُ في المقدمة ماهية المقدمة في العصور كافه ، أما المبحث الاول فكان حديثنا عن الصراعات ما بين مؤيد ورافض ، أما المبحث الثاني فأوضحت فيه أهم الاسباب التي دعتْ شاعراً عباسياً متحضراً الى التمسك بذلك التقليد القديم، ثم أوردت فيه الشواهد العباسية بما يقابلها شواهد جاهلية، ثم اختتمته بخاتمه أوضحتُ فيها أهم النتائج التي توصلتُ اليها، ثم ثبت قائمة الهوامش، ومصادر البحث.
الأمن الاجتماعي لأطفال العراق دراسة في حالة الطفولة العراقية في ظل احتلال داعش
Authors: مجيد علي نورا
Published: October 2020

اهتمت الدراسة بالتعرف على الأوضاع الاجتماعية للطفل العراقي ابان احتلال داعش للمدن العراقية عام 2014 ومنها مدينة الموصل ، اعتمدت الباحثة على منهج المسح الاجتماعي باعتماد الاستبانة من خلال عينة من الاسر في مدينة الموصل للكشف عن أهداف الدراسة ، وتوصلت الدراسة الى مجموعة نتائج أهمها:

عانت الطفولة العراقية الامرين جراء احتلال داعش الإرهابية للمدن العراقية.

تاثر الأطفال في مدينة الموصل بممارسات داعش الإرهابية من قتل وتعذيب وعنف تجاه افراد المجتمع .

ان غالبية الأطفال في المدينة أصيبوا بامراض نفسية وجسدية بسبب ممارسات داعش تجاههم او تجاه احد افراد اسرتهم .

مازالت الكثير من الاسر تعاني من أحوال اطفالها المرضية بسبب ماواجهتها من ظلم وعنف وتعسف من داعش .
أنماط التكوين الفني لنتاجات طلبة المرحلة الثانية في مادة الخط العربي (دراسة تحليلية)
Authors: رشك خضير حسين , كاظم محمد جواد
Published: October 2020

هدف البحث الى الكشف عن أنماط التكوين الفني لنتاجات طلبة المرحلة الثانية في مادة الخط العربي ، آذ أعد الباحث أستمارة تحليل تتكون من (7) فقرات تتضمن كل تكوين وخصائصه ، وبعد تصميمها وعرضها على الخبراء وأجراء التعديلات اللازمة عليها لتكون بصيغتها النهائية، وبعد الـتأكد من صدقها وثباتها قام الباحث بتطبيقها على عينة البحث التي بلغ عددها (28) نتاجا فنيا والذي تمثل مجموع مجتمع البحث البالغ (28) نتاجا أيضا، والتي اختارها الباحث بشكل قصدي مستخدما التحليل وفق الاستمارة المعدة لهذا الغرض فأظهرت النتائج ، أن معظم الأعمال الفنية المنجزة لطلبة المرحلة الثانية للعام الدراسي 2018/2019 ذات نمط تكوين واحد وهو النمط الأفقي وبنسبة 95% وبنسبة5% ذات نمط تكويني دائري. ومن ذلك استنتج الباحث الى أن المستوى المعرفي الضعيف وعدم تلقي المعلومات الوافية حول موضوع أنماط التكوين الفني الرئيسية الأخرى (التكون الشاقولي، والتكوين القطبي، والتكوين الهرمي والتكوين الدائري، والتكوين الانتشاري) وهو ما جعل نتاجاتهم يسودها هكذا نمط .ومن ذلك أوصى الباحث بضرورة العناية بتعليم الطلبة أنواع التكوين الفني الأخرى (التكون الشاقولي، والتكوين القطبي، والتكوين الهرمي والتكوين الدائري) لضمان التنوع والتشكيل لتحقيق الجمال الفني للخط العربي ويكون ذلك من خلال جعله من ضمن مفردات مادة الخط العربي التي تتناول مفهوم التكوين الفني للخط العربي  وعناصره والأسس التي يقوم عليها وكذلك أنماط التكوين التي هي هدف البحث.
MEMFASILITASI ANAK-ANAK UNTUK BELAJAR DALAM MENGHADAPI COVID-19 DI DESA BONTOMATENE KEC. TURATEA
Authors: Mubaraqah Ikhwan
Published: October 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh masyarakat dalam waktu tertentu. oleh karena, sifatnya intraku rikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (SI) harus mengikuti KKLP.
Italy Towards Mandatory Sustainability Reporting. Voluntary Corporate Social Responsibility Disclosure of Italian Companies and Legislative Decree 254/2016 Statements. A Quantitative Analysis of the Last 10 Years
Authors: Balluchi Federica , Furlotti Katia , Torelli Riccardo
Published: October 2020

Corporate Social Responsibility Disclosure (CSRD) is crucial in providing transparent and reliable information. Company characteristics play a key role in CSRD, but legislation is important and positive in increasing the number of companies, which make complete and transparent sustainability disclosure and stimulating CSR initiatives. In 2016, for the first time, Italian Legislative Decree 254/2016 requires ‘public interest entities’, to integrate statutory financial statements with disclosure of environmental, social and governance strategies from financial year 2017 onwards. This chapter investigates the role of company characteristics in influencing voluntary disclosure. The analysis focused on voluntary CSRD (2007–2016) implemented by Italian listed companies in the 10-year period, and shows that in a non-mandatory context the number of CSR reports published grew steadily. It reveals the voluntary behavior of Italian companies, compliance with the requirements of the Decree with reference to the different dimensions of sustainability, and to the use of international standards and guidelines. Findings show also a marked increase of the number of companies, which, in 2017, produced a non-financial report after the entry into force of the new law. The strength of this work is that it investigates what happened in the decade preceding the introduction of the new law tracing the relationship between historical situation, business characteristics and the requirements of the legislative decree. These results and the immediate impact of the new regulation are interestingly linked to the relationship between law and sustainable development and will be directly and indirectly useful for scholars, managers and national and international regulators.
MEMFASISLITASI MASYARAKAT MELAWAN REVOLUSI 4.0 DI DESA BONTOMATENE KEC. TURATEA
Authors: Surianti
Published: October 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh masyarakat dalam waktu tertentu. oleh karena, sifatnya intraku rikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (SI) harus mengikuti KKLP.
MEMFASISLITASI MASYARAKAT MELAWAN REVOLUSI 4.0 DI DESA BONTOMATENE KEC. TURATEA
Authors: Ardi
Published: October 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh masyarakat dalam waktu tertentu. oleh karena, sifatnya intraku rikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (SI) harus mengikuti KKLP.
MEMFASILITASI ANAK-ANAK UNTUK BELAJAR DALAM MENGHADAPI COVID-19 DI DESA BONTOMATENE KEC. TURATEA
Authors: ASTUTI
Published: October 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh masyarakat dalam waktu tertentu. oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (SI) harus mengikuti KKLP.
MEMFASISLITASI MASYARAKAT MELAWAN REVOLUSI 4.0 DI DESA BONTOMATENE KEC. TURATEA
Authors: Subair
Published: October 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh masyarakat dalam waktu tertentu. oleh karena, sifatnya intraku rikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (SI) harus mengikuti KKLP.
Morphodynamic modelling of beach cusp formation: the role of wave forcing and sediment composition
Authors: Daly Christopher , Floc'h France , Almeida Luis Pedro , Almar Rafael , Jaud Marion
Published: October 2020

A field of beach cusps formed during a field experiment at Nha Trang Beach, Vietnam, under accretive conditions. The measured data was used to set-up morphodynamic simulations in XBeach, which was able to simulate cusp formation from an initially long-shore uniform beach profile. Several types of simulations were run in order to observe the resulting variation in mean cusp dimensions (length, depth and height), swash flow patterns, and sediment sorting. Both time-constant (JONSWAP) and time-varying (measured) wave forcing conditions were superimposed on the measured tide. In the former, four wave parameters were varied (wave height, period, direction, and spreading), while in the latter, the median sediment size and sediment composition were varied. The wave period was found to primarily influence long-shore length scales, the wave height cross-shore length scales, and obliquely incident waves enhance all these dimensions particularly under narrow-banded conditions. Cusps are not prominent if the wave energy is too low to effect significant onshore transport, if the wave angle of incidence and spreading are too large (effectively smoothing out swash perturbations), or if the sediment is too fine in relation to the wave conditions (dissipative beaches or highly erosive wave conditions). Coarse sediment generally tends to be located on cusp horns above the waterline, but is otherwise variable depending on cross-shore location and tide levels. As the XBeach model results show large agreement with well-established norms, it may therefore be used to more rigorously study processes that help to initiate cusps in future work.
Global sensitivity analysis of a pure steam dropwise condensation heat transfer model
Authors: Sablowski Jakob , Unz Simon , Beckmann Michael
Published: October 2020

In recent years, established heat transfer models for dropwise condensation (DWC) have been refined to consider the influence of wetting behavior, surface structure and nucleation dynamics on the heat transfer rate in more detail. Despite these efforts to develop more sophisticated models, uncertainties of the model parameters still lead to a high variation of the calculated heat transfer rate. In this study, we apply quantitative sensitivity analysis to a pure steam DWC heat transfer model in order to attribute the variation of the model result to its input parameters. Four scenarios with different variations of the model parameters are discussed and sensitivity coefficients for each parameter are calculated. Our results show that the contact angle and the nucleation site density have the greatest influence on the model result if no additional coating layer is considered. The influence of the nucleation site density is mainly due to the large uncertainties associated with this parameter. In scenarios with an additional coating layer, the heat flux is mainly governed by the thickness of the coating layer, underlining the need for thin conformal coatings to effectively promote DWC. Furthermore, trends within the heat transfer model are discussed and beneficial conditions for a high heat flux are identified for each scenario. The results underline that the wetting properties of functional surfaces should be tailored towards medium contact angles in the range of 70° to 130° and low contact angle hystereses below 10° to achieve high heat flux DWC.
The irrational interplay between partisanship, beliefs about the severity of the COVID-19 pandemic, and support for policy interventions
Authors: Freira Lucia , Sartorio Marco , Boruchowicz Cynthia , Boo Florencia Lopez , Navajas Joaquin
Published: October 2020

The COVID-19 pandemic is a global crisis that has forced governments around the world to implement large-scale interventions such as school closures and national lockdowns. Previous research has shown that partisanship plays a major role in explaining public attitudes towards these policies and beliefs about the severity of the crisis. However, the cognitive roots of this phenomenon remain poorly understood. In principle, partisan gaps in policy support could emerge from cost-benefit analyses from individuals with dissimilar perceptions about the severity of the pandemic, as proposed by rational models of partisan behavior. Alternatively, polarized responses may be driven by social identity motives that are unrelated to individual beliefs, as predicted by theories of tribal partisanship. Here, we tested the predictions of these two models across four experiments (N=1980) performed in four different countries (Argentina, Uruguay, Brazil, and the United States). Participants forecasted the number of COVID-19 deaths in their country after considering either a high or low number. Then, they rated their agreement with a series of interventions. This anchoring procedure, which experimentally induced a large variability in the forecasted number of deaths, did not modify policy preferences. Instead, we observed that partisanship independently modulated the optimism of forecasts and participants’ support for COVID-19 policies. These results, which are against the predictions of the rational partisanship model, have strong policy implications. In particular, our findings suggest that communication strategies aimed at informing the public about the severity of the pandemic will not substantially change levels of support for COVID-19 interventions.
Learning Loss Due to School Closures During the COVID-19 Pandemic
Authors: Engzell Per , Frey Arun , Verhagen Mark D.
Published: October 2020

Suspension of face-to-face instruction in schools during the COVID-19 pandemic has led to concerns about consequences for student learning. So far, data to study this question have been limited. Here we evaluate the effect of school closures on primary school performance using exceptionally rich data from the Netherlands (n≈350,000). We use the fact that national exams took place before and after lockdown, and compare progress during this period to the same period in the three previous years. The Netherlands underwent only a relatively short lockdown (8 weeks), and features an equitable system of school funding and the world's highest rate of broadband access. Still, our results reveal a learning loss of about 3 percentile points or 0.08 standard deviations. The effect is equivalent to a fifth of a school year, the same period that schools remained closed. Losses are up to 60% larger among students from less-educated homes, confirming worries about the uneven toll of the pandemic on children and families. Investigating mechanisms, we find that most of the effect reflects the cumulative impact of knowledge learned rather than transitory influences on the day of testing. Results remain robust when balancing on the estimated propensity of treatment and using maximum entropy weights, or with fixed-effects specifications that compare students within the same school and family. The findings imply that students made little or no progress whilst learning from home, and suggest losses even larger in countries with weaker infrastructure or longer school closures.
Figures of Thought in Marjane Satrapi’s Persepolis and Riad Sattouf’s The Arab of the Future
Authors: Wiese Doro
Published: October 2020

This article takes Deleuze and Guattari’s ideas on art’s inventive function as a point of departure to analyse two graphic narratives that undermine ideas about truthfulness: Marjane Satrapi’s Persepolis and Riad Sattouf’s The Arab of the Future. It is argued that these allegedly autobiographical memoirs undermine genre conventions to create an implied readership who co-witnesses Satrapi’s and Sattouf’s experiences of oppression, racism, and war during their respective childhoods. It is shown how Satrapi and Sattouf undermine the autobiographical pact through graphic narrative’s ‘figures of thought’, a term introduced to capture the formal, thematic, and narrative possibilities of comics and graphic literature to make readers come into contact with unforeseen visions—and to possibly think anew. Specific attention is paid to the narrative voice, which in Satrapi’s and Sattouf’s works often goes beyond the personal perspective to account for collective experiences, as well as to the use of colour and line work that add critical layers to the stories told. In line with Deleuze and Guattari’s arguments, the poetic, which is the productive function of art, is shown to go beyond questions of truthfulness and falseness, allowing for new ways of thinking and for the creation of new worlds.
Funder Acknowledgement
Doro Wiese was a WIRL-COFUND Fellow at the Institute of Advanced Study at the University of Warwick supported by funding from the European Union's Horizon 2020 research and innovation programme, under the Marie Skłodowska Curie Actions COFUND programme (grant agreement number 713548).
Exchanges Discourse Podcast
A Conversation with…Doro Wiese [13:50]
SIMULATION OF THE ELECTROMAGNETIC FIELD OF THE TECHNICAL PRODUCTS IN PRACTICAL TASKS
Authors:   Samara State Technical University, Usenger A.
Published: October 2020

The article considers the issue of modeling the electromagnetic field of a finished industrial product in the ANSYS Electronics Desktop software environment in order to optimize design and engineering solutions.
Urbanization and Sustainability after the COVID-19 Pandemic
Authors: Motta Paolo
Published: October 2020

This article explores the current scenario of urban agglomerations, drawing attention to the growth of population and the process of unruled urbanization that endangers the delicate balance between human settlements and the surrounding environment. It focuses on the heritage values as fundamental elements for a correct urban development and highlights the impacts that metropolises and megacities have on climate change and the effects on them produced by COVID-19. It then looks at the role that minor cities and towns play and the coming opportunity to revamp them using new technologies and connectivity corridors and to mitigate urbanization. It concludes by observing how complex urban problems must be faced with a comprehensive vision that is driven by the social quality approach and an engagement with the BRICS countries.
ХЕМОСЕНСИБИЛИЗАЦИЯ ОПУХОЛЕВЫХ КЛЕТОК ФЕНОЛЬНЫМИ АНТИОКСИДАНТАМИ: РОЛЬ ФАКТОРА ТРАНСКРИПЦИИ NRF2
Authors:   Белорусский государственный университет, Мартинович Г.Г. , Мартинович И.В. ,   Белорусский государственный университет, Вчерашняя А.В. ,   Белорусский государственный университет, Зенков Н.К. ,   Федеральный исследовательский центр фундаментальной и трансляционной медицины, Меньщикова Е.Б. ,   Федеральный исследовательский центр фундаментальной и трансляционной медицины, Черенкевич С.Н. ,   Белорусский государственный университет
Published: October 2020

Pharmacological modification of the redox properties of tumor cells is a promising approach to enhance the efficiency of antitumor therapy. Currently, the transcription factor Nrf2 is considered as a new target for the development of selective chemosensitizers. Nrf2 plays a key role in regulation of cellular redox homeostasis against stress and during adaptation processes. Many natural and synthetic phenolic antioxidants are inducers of Nrf2 transcriptional activity. Due to differences in Nrf2 transcriptional activity between normal and tumor cells, phenolic antioxidants at certain concentrations act as biological regulators the antioxidant activity of which has two different effects: in tumor cells they promote the development of oxidative stress and enhance the effect of antitumor drugs, in normal cells these antioxidants exhibit protective properties. The review discusses the possible molecular mechanisms of action and the prospects for the clinical use of natural and synthetic phenolic antioxidants in antitumor therapy.
ВЛИЯНИЕ МИКРОВОЛНОВОГО ИЗЛУЧЕНИЯ НА ЧУВСТВИТЕЛЬНОСТЬ КЛЕТОК К ОДНОАТОМНЫМ СПИРТАМ В ОБОГАЩЕННОЙ ТРОМБОЦИТАМИ ПЛАЗМЕ
Authors:   Фрязинский филиал Института радиотехники и электроники им. В.А. Котельникова РАН, Казаринов К.Д. , Щелконогов В.А. ,   Фрязинский филиал Института радиотехники и электроники им. В.А. Котельникова РАН,   Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России,   МИРЭА - Российский технологический университет, Баранова О.А. ,   Фрязинский филиал Института радиотехники и электроники им. В.А. Котельникова РАН,   Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России, Чеконов А.В. ,   Фрязинский филиал Института радиотехники и электроники им. В.А. Котельникова РАН,   Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России, Соловьева Э.Ю. ,   Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России, Федин А.И. ,   Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России
Published: October 2020

We present the results of experimental studies on the aggregation of blood cells in platelet-rich plasma in the presence of an aggregation inducer rhystomicin under the effects of low-intensity radiation of extremely-high frequency. Primary alcohols were used as stimulators for partial degradation of protein-lipid bilayer in the cell membrane. The results showed that exposure to radiation of extremely-high frequency reduces the extent of rhystomicin-induced platelet aggregation and changes the angle of inclination of the aggregatogram. This study revealed a two-phase nature of the effects of alcohols on platelet aggregation - the first phase is characterized by a decrease in aggregation and in the angle of inclination of the aggregatogram, the second phase includes an increase in platelet aggregation and in the angle of inclination simultaneously with an increase in the concentration of alcohols in the sample. A possible mechanism underlyinhg the observed effects is under debate.
ВЛИЯНИЕ УСЛОВИЙ КУЛЬТИВИРОВАНИЯ МЕЗЕНХИМАЛЬНЫХ СТВОЛОВЫХ КЛЕТОК НА ИХ ЖИЗНЕСПОСОБНОСТЬ ПРИ ТРАНСПЛАНТАЦИИ В СУБРЕТИНАЛЬНОЕ ПРОСТРАНСТВО
Authors:   Калужский филиал НМИЦ «МНТК «Микрохирургия глаза» имени академика С.Н. Федорова» Минздрава России, Плахотний М.А. , Кодунов А.М. ,   Калужский филиал НМИЦ «МНТК «Микрохирургия глаза» имени академика С.Н. Федорова» Минздрава России, Горина Е.В. ,   Московский физико-технический институт (национальный исследовательский университет), Бояринцев В.В. ,   Московский физико-технический институт (национальный исследовательский университет), Трофименко А.В. ,   Московский физико-технический институт (национальный исследовательский университет), Бирюков С.А. ,   Московский физико-технический институт (национальный исследовательский университет), Фильков Г.И. ,   Московский физико-технический институт (национальный исследовательский университет)
Published: October 2020

The use of mesenchymal stem cells is an effective treatment strategy for a number of retinal degenerative diseases. Limited survival of these cells following transplantation remains a significant barrier in achieving a therapeutic effect. It has been shown earlier that hypoxia-grown mesenchymal stem cells display enhanced proliferative activity. We hypothesized that such cultivation condition could be beneficial for successful injection of these cells into the subretinal region. For this purpose, we isolated mesenchymal stem cells from mouse red bone marrow, described phenotypic characterization and the ability of these cells to chondrogenic, osteogenic and adipogenic differentiation, and proliferative activity in hypoxic (5% of oxygen in the atmosphere) and normoxic (21% of oxygen in the atmosphere) conditions. In the same manner, we isolated mesenchymal stem cells from red bone marrow obtained from GFP-expressing C57 black mice. After preliminary cultivation under normoxia (control cells) or hypoxia (experimental cells), the cells were loaded with magnetic particles and injected into the subretinal region of rabbit eyes...
ВЛИЯНИЕ ОСМОЛИТОВ НА БИОЛЮМИНЕСЦЕНТНУЮ РЕАКЦИЮ БАКТЕРИЙ: СТРУКТУРНО-ДИНАМИЧЕСКИЕ АСПЕКТЫ
Authors:   Сибирский федеральный университет, Суковатый Л.А. , Лисица А.Е. ,   Сибирский федеральный университет, Кратасюк В.А. ,   Сибирский федеральный университет,   Институт биофизики СО РАН, Немцева Е.В. ,   Сибирский федеральный университет,   Институт биофизики СО РАН
Published: October 2020

The effects of viscous media with glycerol and sucrose (10-40%) on the kinetics of the bacterial bioluminescent reaction have been investigated by stopped-flow technique. Increment of quantum yield in media with 10% of both osmolytes was shown. Higher concentrations of glycerol, up to 30-40%, were found to reduce the efficiency of the reaction, while this effect was not observed in the media with sucrose. The molecular dynamics simulation was used to study the structure of bacterial luciferase surrounded by either water molecules solely or by mixture of water with various numbers of glycerol/sucrose molecules. It was found that both cosolvents at studied concentrations did not cause a significant change in conformation of bacterial luciferase. The calculated root mean square fluctuations for Cα-atoms of bacterial luciferase α-subunit indicated that the higher flexibility of the enzyme mobile loop could be responsible for increment of quantum yield in the presence of 10% of both osmolytes. The active site of bacterial luciferase was found to be accessible for glycerol molecules while sucrose did not enter catalytic gorge. Moreover, at 30% and 40% concentration the glycerol molecules were found to locate in the active site of bacterial luciferase throughout the whole simulation time (40 ns) and to exclude water molecules, which can explain the experimentally obtained reaction quantum yield decrease.
ДИНИТРОЗИЛЬНЫЕ КОМПЛЕКСЫ ЖЕЛЕЗА C ТИОЛСОДЕРЖАЩИМИ ЛИГАНДАМИ ПРЕДСТАВЛЕНЫ В ЖИВЫХ ОРГАНИЗМАХ В ОСНОВНОМ ИХ БИЯДЕРНОЙ ФОРМОЙ
Authors:   Федеральный исследовательский центр химической физики им. Н.Н. Семёнова РАН, Микоян В.Д. , Бургова Е.Н. ,   Федеральный исследовательский центр химической физики им. Н.Н. Семёнова РАН, Бородулин Р.Р. ,   Федеральный исследовательский центр химической физики им. Н.Н. Семёнова РАН, Ванин А.Ф. ,   Федеральный исследовательский центр химической физики им. Н.Н. Семёнова РАН,   Институт регенеративной медицины Первого Московского государственного медицинского университета имени И.М. Сеченова МЗ РФ
Published: October 2020

The number of mononitrosyl iron complexes with diethyldithiocarbamate, formed in the liver of mice in vivo and in vitro after intraperitoneal injection of binuclear dinitrosyl iron complexes with N-acetyl-L-cysteine or glutathione, S-nitrosoglutathione, sodium nitrite or the vasodilating drug Isoket® was assessed by electron paramagnetic resonance (EPR). The number of the said complexes, in contrast to the complexes, formed after nitrite or Isoket administration, the level of which sharply increased after treatment of liver preparations with a strong reducing agent - dithionite, did not change in the presence of dithionite. It was concluded that, in the first case, EPR-detectable mononitrosyl iron complexes with diethyldithiocarbamate in the absence and presence of dithionite appeared as a result of the reaction of NO formed from nitrite with Fe2+-dieth- yldithiocarbamate and Fe3+-diethyldithiocarbamate complexes, respectively. In the second case, mononitrosyl iron complexes with diethyldithiocarbamate appeared as a result of the transition of iron-mononitosyl fragments from ready-made iron-dinitrosyl groups of binuclear dinitrosyl complexes, which is three to four times higher than the content of the mononuclear form of these complexes in the tissue...
ИНФРАКРАСНАЯ СПЕКТРОСКОПИЯ СЫВОРОТКИ КРОВИ БОЛЬНЫХ ОНКОГЕМАТОЛОГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ
Authors:   Санкт-Петербургский государственный университет, Тельная Е.А. , Плотникова Л.В. ,   Санкт-Петербургский государственный университет, Гарифуллин А.Д. ,   Российский научно-исследовательский институт гематологии и трансфузиологии ФМБА России,   Военно-медицинская академия им. С.М. Кирова,   Северо-Западный государственный медицинский университет им. И.И. Мечникова, Кувшинов А.Ю. ,   Российский научно-исследовательский институт гематологии и трансфузиологии ФМБА России,   Военно-медицинская академия им. С.М. Кирова,   Северо-Западный государственный медицинский университет им. И.И. Мечникова, Волошин С.В. ,   Российский научно-исследовательский институт гематологии и трансфузиологии ФМБА России,   Военно-медицинская академия им. С.М. Кирова,   Северо-Западный государственный медицинский университет им. И.И. Мечникова, Поляничко А.М. ,   Санкт-Петербургский государственный университет
Published: October 2020

A comparative analysis was performed of the secondary structure of serum proteins in patients with multiple myeloma, chronic lymphocytic leukemia patients and healthy donors. Determination of serum protein secondary structure was accomplished by the application of IR spectroscopy. It has been shown that the proposed approach allows to detect a decrease in the length of α-helical regions and an increase in the content of β-sheets in the serum of patients with multiple myeloma compared to healthy donors and chronic lymphocytic leukemia patients.
КЛАССИФИКАЦИЯ АДАПТИВНЫХ ПРИЗНАКОВ И ВЫВОД КРИТЕРИЕВ ИХ ЭВОЛЮЦИОННОЙ ОПТИМАЛЬНОСТИ
Authors:   Первый Московский государственный медицинский университет имени И.М. Сеченова МЗ РФ, Овсянников Л.Л. , Шпитонков М.И. ,   Вычислительный центр им. А.А. Дородницына Федерального исследовательского центра «Информатика и управление» РАН
Published: October 2020

This study proposes a mathematical model of biological community dynamics which is represented by a system of equations that describe the dynamics of ecosystem variables - population density; body weight of mature individuals; the density of energy received by an individual with food - and takes into account the age structure of the consumer's population. Using the results on competition obtained for point models by other researchers, algorithms for determining the evolutionarily optimal values of adaptive traits of mature individuals of the population were obtained. It has been shown that during food resource competition between populations each harboring a different set of traits, selection favored only the population which will survive and have larger reproductive function, that corresponds to the general criterion for optimality in adaptive evolution. The classification of traits by types is carried out, it is shown that each type corresponds to its own criterion for optimality in adaptive evolution. Simple algorithms for a search for evolutionarily optimal values of various adaptive traits and body weight are proposed, the optimal distribution of energy consumption for all types of vital functions of the organism is determined. Optimality in adaptive evolution of these traits is illustrated by a numerical experiment.
КОМПЬЮТЕРНАЯ ОЦЕНКА ВЕРОЯТНОСТИ ОБРАЗОВАНИЯ МЕТАБОЛИТОВ КСЕНОБИОТИКОВ В ОРГАНИЗМЕ ЧЕЛОВЕКА
Authors:   Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича, Филимонов Д.А. , Рудик А.В. ,   Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича, Дмитриев А.В. ,   Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича, Лагунин А.А. ,   Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича,   Российский национальный исследовательский медицинский университет имени Н.И. Пирогова, Поройков В.В. ,   Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича
Published: October 2020

In the human body, xenobiotics undergo biotransformation, that may result in the formation of metabolites physical, chemical and biological properties of which differ significantly from the initial substances; the formation of toxic and reactive metabolites is possible. An experimental study of xenobiotic biotransformation appears challenging and the development of computational methods of prediction is therefore an important task. The main disadvantage of computational methods includes that a large number of possible metabolites are generated leading to a "combinatorial explosion". The purpose of this work is to select criteria for optimizing the prediction of metabolites within the framework of our web resource MetaTox (http://www.way2drug.com/MG), which is freely available via Internet. We compared the performance of additive and multiplicative methods for assessing the probability of the formation of metabolites and shown the additive approach's superiority.
EFFECT OF 5 WEEKS RADIATION THERAPY ON PULMONARY FUNCTIONS IN BREAST CANCER PATIENTS: A PILOT STUDY
Authors: Shastri Nikita Anil , Diwate Abhijit D , Das Arijit Kumar , Shete Reshma
Published: October 2020

ABSTRACT:

BACKGROUND: The lung has a very little regenerative capacity; it cannot tolerate long doses of radiation. The critical injuries that eventually lead to impaired ventilation and diffusion capacity are related to total dose, its fractionation, and volume of lung irradiated. The absorption of ionizing radiation causes immediate subcellular and cellular damage while its gross morphological expression in terms of tissue injury.

Aim of study: To observe the effect of 5 weeks of Radiation Therapy on Pulmonary Functions in breast cancer patients Methodology: The study was carried out on ten subjects ranging in the age group of 35-65 years where PFT parameters were recorded initially and at the end of every week for five weeks. Then parameters were compared pre radiation and every week after the radiation therapy for five weeks.

RESULT: Data was analyzed in terms of the mean difference. Statistically, there were no significant changes seen in the PFT parameter values that are pre- radiation and post-radiation every week for five weeks and the p values obtained were for following parameters 1) FVC – 0.487 2) FEV1 – 0.863 3) FEV1/FVC – 0.487 4) FEF25-75% - 5) PEFR- .

CONCLUSION: There were no significant changes that were found in the parameters of the pulmonary function test. Changes in lung volume and capacities are expected after Radiation therapy that is risk of damaging pulmonary parenchyma and losing type 2 pneumocytes but patient never present changes due to compensation in relation to healthy changes which did not receive radiation.

KEY WORDS: Breast Cancer,Radiation Therapy,Pulmonary Function Test
Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report
Authors: Virkar Mayuresh D. , Chauhan Rajkumar , Chadha Pranav , Talapatra Kaustav , Rodrigues Reuben Jake , Shrivastava Amrita , Sen Santanu , Tulpule Sameer
Published: October 2020

Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.
Momentum Effect in Developed and Emerging Stock Markets
Authors: Imran Zulfiqar Ali , Wong Woei-Chyuan , Ismail Rusmawati
Published: October 2020

The study aims to reaffirms the existence of short-term momentum effect in 13 developed and emerging stock markets where previous literature has lack of consensus. Although many studies emphasis on the existence of momentum effect, but still, there are substantial number of researchers that deny the its presence. The contradictory finding of many researchers over the existence of momentum effect, raises a serious question, to what extend our stock markets are informationally efficient and whether investor can make abnormal profits by using momentum investment strategies. This study applies momentum investment strategy, J6K6, to calculate momentum returns. Our study finds negative significant momentum effect in all 13 stock markets. Although momentum effect is present in 13 countries but Investors are not able to attain abnormal profit through momentum investing. These findings have an utmost importance for practitioners that they should not adopt momentum investment strategies in these countries as these strategies are generating lose. Moreover, stock market regulators should formulate these markets on the notion of efficient market hypothesis.
Efficiency of organomineral fertilizer “Bioklad” in mixed sowing of oats with peas in the conditions of the forest-steppe zone Republic of North Ossetia-Alania
Authors: Ikoeva Larisa , Haeva Oksana
Published: October 2020

Abstract. The authors present the results of the application of complex organo-mineral fertilizer “Bioklad” on mixed sowing of oats with peas in the conditions of the forest-steppe zone Republic of North Ossetia-Alania. The purpose of the work is to study the effectiveness of the use of the organomineral fertilizer “Bioklad” on the yield and nutrition of mixed sowing of oats with peas in the conditions of the forest-steppe zone Republic of North Ossetia-Alania. Methods. Studies on the tasks were carried out in 2016–2018 at the experimental site of the North Caucasus Research Institute of Mountain and Foothill Agriculture – branch of the Federal Center “Vladikavkaz Scientific Center of the Russian Academy of Sciences” in the conditions of the forest-steppe zone Republic of North Ossetia-Alania according to generally accepted methods. The soil of the experimental plot is medium-power heavy loamy leached chernozem, lined with pebbles. Results. The use of fertilizer “Bioklad” had a significant impact on the timing, fullness of shoots and the density of standing plants up to harvest. The field germination rate for peas varied between 70,5 and 72,4 %, while the oat rate was 76,4 to 80 %. The option with seed inoculation was highlighted. According to the dynamics of the height of the plants also stood out the option with the inoculation of seeds. The use of complex fertilizer “Bioklad” had a positive effect on the yield and quality of the green mass of oats with peas. The largest amount of phytomass was obtained under the variant with inoculation of seeds – 283,3 c/ha, which is higher than the control version at 68,3 c/ha. In terms of the content of digestible protein, the harvest of the mixture of oats with peas exceeded the zootechnical norm, the yield from one hectare reached 6,0–6,9 c/ha, against 5,2 c/ha in control, which per feed unit was 113,7–119,9 g. The collection of feed units amounted to 50,02–60,68 kg/ha, and in the control 44,23 kg/ha, feed protein units, respectively: 55,01–64,84 kg/ha; 48,12 kg/ha. Scientific novelty. For the first time in the conditions of the forest-steppe zone Republic of North Ossetia-Alania studied the effect of complex organomineral fertilizer “Bioklad” on plant growth processes, formation of green mass, quality of products in a two-component mixture (oats + peas).
The result of using a haylage made of sandpaper in the diets of dairy cows
Authors: Morozkov Nikolay , Maysak Galina
Published: October 2020

Abstract. The purpose of the research was to study the effect of feeding by sainfoin haylage in the dry period (21 days before calving) and in the period of early lactation (50 days after calving) on the metabolic processes of dairy cows and the results of reproduction. The article gives the brief description of sainfoin (Onobrychis arenaria Kit.) as a valuable feed protein crop that can be successfully cultivated in Perm region conditions. High sugar content in sainfoin forage was noted 4.86 %, which is 1.6 times higher compared with standard class 1 for legume haylage first class. Methods. Experiments for use of sainfoin haylage in feeding highly productive cows were conducted in 2018. Cows of the experimental groups received a diet including sainfoin haylage. Cows in the control group received 5 kg of poaceous grass hay as a fodder. The first experimental group got 50 % of forage dry matter as sainfoin haylage. The second experimental group received 100 % of forage dry matter as sainfoin haylage. Results. Hay replacing by equal dry matter amount of sainfoin haylage provided positive effect on immuno-biochemical parameters of cows blood. The protein content increased in the blood plasma of cows during the time of the experiment: in the second experimental group by 4.3 g/l (5.47 %, p < 0.01) and reached 82.80 g/l, in the first experimental group by 1.72 % (p < 0.05), in the control – by 2.28 % (p < 0.05). Feeding sainfoin haylage to cows had a positive effect on their reproductive functions. The service period for cows of the second experimental group was shorter by 8.1 days (9.28 %, p < 0.01) compared with the first experimental group and by 21 days (24.05 %, p < 0.05) shorter than in the control group. The scientific originality of the work is that for the first time the biochemical composition of sainfoin was studied thoroughly in Perm region and the results of sainfoin haylage feeding to animals were presented.
Increasing the information capacity of a fiber-optic multi-sensor converter of binary mechanical signals into electrical signals
Authors: Grechishnikov V. M. , Komarov E. G.
Published: October 2020

The design and operation principle of a multi-sensor Converter of binary mechanical signals into electrical signals based on a partitioned fiber-optic digital-to-analog Converter with a parallel structure is considered. The digital-to-analog Converter is made from a set of simple and technological (three to five digit) fiber-optic digital-to-analog sections. The advantages of the optical scheme of the proposed. Converter in terms of metrological and energy characteristics in comparison with single multi-bit converters are justified. It is shown that by increasing the number of digital-analog sections, it is possible to repeatedly increase the information capacity of a multi-sensor Converter without tightening the requirements for its manufacturing technology and element base. A mathematical model of the proposed Converter is developed that reflects the features of its operation in the mode of sequential time conversion of the input code vectors of individual fiber-optic sections into electrical analogues and the formation of the resulting output code vector.
Neural networks application for phasechronometric measurement information processing
Authors: Boldasov D. D. , Drozdova J. V. , Komshin A. S. , Syritskii A. B.
Published: October 2020

This article describes the processing technique of measuring phasechronometric information based on the neural networks use. The novelty of the proposed approach lies in the choice of a classification feature and the perceptron algorithm use as an algorithm for binary classification performing. In this article, to assess the concept operability, the simplest binary classification of the lathe operation modes is made: idle or cutting.