bluuebunny/crossref_metadata_2025 huggingface dataset:
Swelling Prediction of Expansive Soil Using Numerical Method Analysis
Authors: Diaz Ishak  , Hidayat Wirman , Sudisman Rangga Adiprima , Aristo Arlyn
Published: January 2023

Expansive soil is one of the factors that cause road damage in Indonesia. Its behavior is influenced by moisture content. At high moisture content, expansive clay has a very low bearing capacity and high swelling and shrinkage rate compared to other soil types. This soil expansion causes a heave force on the road pavement. When the force exceeds the strength of the pavement, the pavement will deform and break as the initial damage is created. Therefore, it is critical to investigate the effect of moisture content on the swelling-shrinkage behavior of expansive soil. In this study, soil expansion is numerically predicted using the finite element approach on ABAQUS compared to the laboratory expansion index test. The geometric shape and loading of the soil model are the same as the sample shape and loading of a laboratory expansion index test. The Mohr-Coulomb soil constitutive model with sorption is used to simulate water absorption in partially saturated soils. Coupled wetting liquid flow and porous medium stress analysis are used to simulate swelling and shrinkage. The simulation is divided into two types: geostatic, which simulates soil model loading, and coupled pore fluid, which simulates changes in water content. The simulation is then compared to the laboratory test for validation. The numerical analysis results show that the model's accuracy depends highly on the constitutive soil model, whereas the Mohr-Coulomb model shows a limitation in accuracy with the maximum swelling in the simulation is 21.704%, while the average maximum swelling in laboratory testing is 15.515%.
Improving bearing capacity using tire-derived-geo-cylinder – a haul road case study in Jalan Sikar Penajam Paser
Authors: Rus Tatag Yufitra , Susanto Willy , Sulardi
Published: January 2023

This paper showcases a potential solution to improve soil bearing capacity using tire-derived-geo-cylinder (TDGC). TDGC uses used tires to provide confining pressure and tensile strength, hence improving the soil’s bearing capacity. The solution is applied for a haul road project on Jalan Sikar Penajam Paser. The site is frequently passed by large vehicles such as large trucks for the transportation of wooden logs and other heavy equipment. The tires used for TDGC are used tires of type LT245/75R16, which has a standard rim of 16 mm, a tire width of 248 mm, and an overall diameter of 780 mm. This category of tires has a load index of 1250-1600 kg. The load index is the value representing the tire's capacity to withstand load. The improvement in bearing capacity is evaluated using dynamic cone penetrometer (DCP) tests. In addition, the DCP tests were also used to interpret the Californian Bearing Ratio (CBR) values. The results show that without TDGC, the average CBR value is only 4.7%. In contrast, with TDGC, the average CBR increased to 17.2%, an increase of 265%. The CBR value obtained with TDGC places the soil into fair category for Subbase course. The average bearing capacity value obtained before TDGC was about 75 kN/m2 and with TDGC, the soil experienced a significant increase in bearing capacity value to 245 kN/m2. The increase of bearing capacity and CBR value from application of TDGC are due to the combination of the tires and stone fill. The tires provide tensile strength to resist lateral soil pressure as well as increased confining pressure, hence increasing the compressive strength.
FACTORES QUE AFECTAN LA FIJACIÓN DE NITRÓGENO EN EL SISTEMA Inga spp. -RIZOBIOS EN CAFETALES DE SOMBRA
Authors: Velasco-Trejo Jorge Alejandro , Alarcón-Gutiérrez Enrique , García-Pérez José Antonio , Pineda-López María Del Rosario , Flores-Estévez Norma
Published: January 2023

Background. The results of a review on the factors that affect nitrogen fixation in the Inga-café system are presented. The nitrogen contribution that the Inga Miller tree genus provides to shade coffee plantations and the factors that affect its stability in biological nitrogen fixation are scarcely recognized. This work delves into the ecological factors and glyphosate herbicides that can affect the symbiosis of Inga spp. with diazotrophic bacteria in their roots (rhizobia), which form nodules and carry out biological nitrogen fixation. Methodology. Different information sources such as EBSCO, Scopus and Google Schoolar were reviewed, with logical or Boolean data search. 183 papers were used to address the factors that affect the symbiosis between trees of the Inga genus and rhizobia. The findings were organized in: Inga Miller taxonomy, shade coffee plantations with Inga spp., symbiosis between Inga spp. and Bradyrhizobium spp., ecological factors that affect the functioning of the Inga spp.-rhizobia symbiosis and the agrochemical factor: glyphosate herbicide. Results. The genus Inga is recognized as a clade Mimosoideae nested in the subfamily Caesalpinioideae. Shade coffee plantations with Inga are established below 23º N and 30º S, up to 3,100 m.a.s.l. and the symbiont genus is predominantly Bradyrhizobium spp. whose ecological limits of Inga spp-rhizobia were: altitude [988.7-1,381.5 m.a.s.l.], annual precipitation [2,048.4-2,064.36 mm], temperature [20.39-21.93 ºC] and soil pH [4.88-5.42 pH]. Glyphosated herbicides, as an external stimulus, can reduce the benefit of biological nitrogen fixation and erode the soil by keeping it devoid of vegetation. Additionally, some Bradyrhizobium spp. (thiO gene), which oxidizes glyphosate to aminomethylphosphonic acid (AMPA), could be a potential glyphosate degrader in the soil. Implications. Shade coffee plantations with 205-250 trees per hectare of Inga spp. allow fixing around 45 kg of N ha-1 year-1. This review may allow the adoption of new observational or experimental studies of the Inga spp.-rhizobia symbiosis, to approach the performance that favors the biological fixation of nitrogen in shade coffee plantations. Conclusions. The review indicates that there is a specific association between Inga spp. and Bradyrhizobium spp., that ecological factors, including the agronomic management with glyphosated herbicides can decrease nitrogen fixation performance during the symbiosis between Inga spp. and rhizobia. No systematic studies of the symbiosis-environment-agrochemical interaction in shade coffee plantations were found.
Գարեգին Ա. Կաթողիկոս Ամենայն Հայոց․ աստվածաբանական դիմանկար
Authors: ԱՆԱՆՅԱՆ Տ․ ՇԱՀԵ ԾԱՅՐԱԳՈՒՅՆ ՎԱՐԴԱՊԵՏ
Published: January 2023

SUMMARY
The theological legacy of the late Catholicos of All Armenians, Karekin I (1932-1999) includes a variety of spiritual essays, reflections, sermons, books and studies on the historical-theological tradition of the Armenian Church. As a famous orator and ecumenical leader, he left his indelible mark on the modern ecumenical movement. This article aims at creating a theological portrait of His Holiness, reflecting especially on the two main views of his thought: experience as method and theology in dialogue. Some parallels were made also between His Holiness’s theological legacy and the public theology’s methods. In the second part of the article a brief outline of his ecumenical views and vision was presented, as well.

РЕЗЮМЕ
Богословское наследие покойного Католикоса Всех Армян Гарегина I (1932-1999) включает разнообразные духовные очерки, размышления, проповеди, книги и исследования по истории и богословской традиции Армянской Апостольской Церкви. Как известный оратор и экуменический лидер, он оставил неизгладимый след в современном экуменическом движении. Данная статья направлена на создание богословского портрета Его Святейшества, в особенности выделяя два основных направления его мысли: духовный опыт как метод и богословие в диалоге. Были также проведены некоторые параллели между богословским наследием Его Святейшества и методами так называемого публичного богословия (public theology). Во второй части статьи также представлен краткий очерк его экуменических взглядов и видений.
Pengaruh Pemberian Pakan Komplit Berbasis Silase Jerami Jagung dengan Level yang Berbeda terhadap Konsumsi, Kecernaan Serat Kasar dan Lemak Kasar Sapi Bali Penggemukan
Authors: Babu Maria Elisabeth , Sulistijo Edi Djoko , Maranatha Grace
Published: January 2023

Penelitian dilaksanakan di UPT Laboratorium Lapangan Lahan Kering, Universitas Nusa Cendana Kupang tanggal 25 Januari sampai 8 April 2021. Tujuan untuk mengetahui pengaruh pemberian pakan komplit berbasis silase jerami jagung dengan level yang berbeda terhadap konsumsi dan kecernaan serat kasar serta lemak kasar sapi Bali penggemukan. Digunakan 12 ekor sapi Bali jantan dengan kisaran umur 1-1,5 tahun dan bobot badan 66-93kg dengan rataan 80,16kg serta (KV) koefisien variasi sebesar 10,28%. Penelitian ini dirancang menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 3 ulangan. Perlakuan dalam penelitian ini yaitu: P0; pakan silase jerami jagung (80%) + konsentrat (20%), P1; pakan silase jerami jagung (60%) + konsentrat (40%), P2; pakan silase jerami jagung (40%) + konsentrat (60%), P3; pakan silase jerami jagung (20%) + konsentrat (80%). Data yang diperoleh dianalisis menggunakan analisis ragam dan bila ada pengaruh maka dilanjutkan dengan uji Duncan. Hasil  penelitian ini menunjukkan konsumsi serat kasar (g/e/h) : P0; 539,85, P1; 485,16, P2; 411,21, P3; 434,81. Konsumsi lemak kasar (g/e/h) : P0; 67,75, P1; 71,55, P2; 71,03, P3; 87,86. Kecernaan serat kasar (%) : P0; 56,0, P1; 58,37, P2; 59,19, P3; 60,23. Kecernaan lemak kasar (%) : P0; 42,03, P1; 45,28, P2; 53,60, P3; 49,18. Hasil analisis ragam menunjukkan bahwa perlakuan P0-P3 berbeda nyata (P<0,05) dan P0-P2 berbeda sangat nyata (P<0,01) pada konsumsi serat kasar,  sedangkan konsumsi lemak kasar, kecernaan serat kasar serta kecernaan lemak kasar berpengaruh tidak nyata (P>0,05). Pembahasan diatas disimpulkan bahwa pemberian pakan komplit berbasis silase jerami jagung selama 9 minggu berpengaruh positif terhadap konsumsi serat kasar dengan perlakuan P2 silase jerami jagung (40%) + konsentrat (60%) dan P3 silase jerami jagung (20%) + konsentrat (80%) memiliki kecenderungan hasil terbaik sedangkan konsumsi lemak kasar, kecernaan serat kasar dan lemak kasar memberi pengaruh yang relatif sama.
Pengaruh Pemberian Pakan Komplit Kombinasi Silase Batang Pisang Dan Konsentrat Dengan Level Yang Berbeda Terhadap Nilai Hemoglobin, Eritrosit Dan Hematokrit Darah Sapi Bali Penggemukan
Authors: Sobang Alex Umbu Laiya , Rosnah Upik Syamsiar , Kihe Johny Nada
Published: January 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian pakan komplit kombinasi silase batang pisang dan konsentrat dengan level yang berbedah terhadap nilai Hemoglobin, Eriktrosit dan hematokrit darah sapi Bali penggemukan. Ternak sapi Bali jantan sebanyak 12 ekor dengan kisaran umur 1-1,5 tahun dan berat badan 80,5-97 kg (x̄=89,4 kg) digunakan dalam penelitian ini. Metode yang digunakan adalah metode percobaan menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dan 4 ulangan.  Adapun perlakuan dalam penelitan adalah RO = pakan komplit (silase batang pisang 80% + 20% konsentrat), R1= pakan komplit (silase batang pisang 70% + konsentrat 30%), R2= pakan komplit (silase batang pisang 60% + konsentrat 20%) R3 = pakan komplit (silase batang pisang 50% + konsentrat 20%). Variabel yang diuji dalam penelitian ini adalah hemoglobin, eritrosit dan hematokrit . Data yang diperoleh dianalisis menggunakan Analisis Of Variance (ANOVA). Dari hasil penelitian diperoleh rataan nilai hemoglobin untuk Ro =10.35±0.68 g/dl, R1 = 11.24±0.60 g/dl, R2 = 11.37±0.45 g/dl, dan R3 = 11.55±0.51 g/dl. Rataan nilai Eritrosituntuk perlakuan Ro = 9.78±047(106/µl), R1 = 10.09±0.05 (106/µl), R2 = 10.78±0,05 (106/µl), dan R3 =10.38±0.33 (106/µl). nilai Hematokrit untuk perlakuan Ro = 11.82±0,61(104/µl) , R1 = 12.70±0.44 (104/µl), R2 = 12.28±1.07(104/µl) dan R3 =11.89± 0.72 (106/µl).  Hasil ANOVA menunjukan bahwa perlakuan berpengaruh tidak nyata P>0,05 terhadap nilai hemoglobin, eritrosit dan hemotokrit darah sapi Bali penggemukan. Disimpulkan bahwa ternak sapi Bali penggemukan yang mengkonsumsi pakan komplit kombinasi silase batang pisang dan konsentrat dengan level yang berbeda memberikan kecendrungan yang relaive sama untuk profil darah yaitu nilai hemoglobin, eriktrosit, dan hematokrit dan berada dalam kisaran normal.
Pengaruh Penambahan Tepung Daun Kelor Dalam Pembuatan Nugget AyamTerhadap Mutu Organoleptik
Authors: Aristika Gega Indah , Riwu Agustinus Ridolf , Sulmiyati Sulmiyati
Published: January 2023

Penelitian ini dilatarbelakangi adanya kelemahan dari olahan nugget dikarenakan komposisi sayuran yang kurang.. Oleh sebab itu, sangat diperlukan pembaruan  untuk digunakan dalam penambahan sayuran pada nugget ayam. Dilihat dari kandungan yang dimiliki oleh daun kelor rupanya sayuran ini sungguh  mempunyai kemampuan yang  ditambahkan pada produk olahan nugget. Penelitian ini memiliki tujuan untuk menganalisis pengaruh penambahan tepung daun kelor dalam pembuatan nugget ayam terhadap mutu organoleptik. Rancangan yang dipakai yaitu Rancangan Acak Lengkap (RAL) yang mencakup pada 4 perlakuan dan 4 ulangan. Perlakuan 1 = 100% adonan  nugget ayam tanpa tepung daun kelor (kontrol), perlakuan 2 = penambahan 10% tepung daun kelor berdasarkan berat daging ayam, perlakuan 3 = penambahan 20% tepung daun kelor berdasarkan berat daging ayam, dan perlakuan 4 = penambahan 30% tepung daun kelor berdasarkan berat daging ayam. Parameter yang diteliti terdiri dari warna, aroma, rasa dan tekstur. Hasil penelitian menunjukkan bahwa peningkatan level daun kelor pada nugget ayam mengalami penurunan mutu organoleptik. Kesimpulan warna, aroma, rasa dan tekstur mengalami penurunan dengan penambahan 30% tepung daun kelor. Perlakuan  yang terunggul dari mutu organoleptikyaitu pada perlakuan yang ditambahkan tepung daun kelor 10% (P1).
Konsentrasi VFA, N-NH3 dan pH In-Vitro Ransum Mengandung Bekatul Sorgum sebagai Pengganti Jagung pada Level Berbeda
Authors: Bansae Dominggus , Nenobais Mariana , Lestari I Gusti Y. , Hartati Erna
Published: January 2023

Suatu eksperimen dengan tujuan mengetahui konsentrasi Volatile Fatty Acid (VFA), N-NH3 dan pH In-vitro ransum yang mengandung bekatul sorgum yang menggantikan jagung pada level yang tidak sama. Eksperimen dilakukan di Laboratorium Kimia Pakan Fakultas Peternakan, Kelautan dan Perikanan Undana Kupang. Eksperimen ini diarahkan pada November 2019 - Februari 2020, terdiri dari 1 bulan pengumpulan bahan baku konsentrat, penyusunan konsentrat dan pengambilan sampel serta 1 bulan analisis sampel. Eksperimen dengan desain rancangan acak lengkap (RAL) yaitu empat perlakuan dan empat ulangan. Dengan percobaan sebagai berikut P0= Konsentrat + tepung jagung 100% tanpa dedak sorgum: P1= Konsentrat, 75% tepung jagung + 25% dedak sorgum, P2= Konsentrat, 50% tepung jagung + 50% dedak sorgum, P3= Konsentrat, 25% tepung jagung + 75% dedak sorgum. Analisis data yang dikumpulkan menggunakan Analisis Of Variance (ANOVA). Hasil eksperimen menyatakan bahwa dari perlakuan yang digunakan berpengaruh tidak nyata (P>0,05) terhadap, VFA, N-NH3 dengan pH In-vitro. Dari hasil penelitian dapat disimpulkan, dedak sorgum mampu mensubsitusi jagung sampai pada level 75% dalam konsentrat.
Penggunaan Mikroorganisme Lokal (MOL) Dalam Silase Isi Rumen Sapi terhadap Kecernaan Bahan Kering, Bahan Organik dan Total Digestible Nutrient (TDN) secara In Vitro
Authors: Bano Novia Aurelia , Hilakore Maritje A. , Lawa Emma D. Wie , Lazarus Edwin J. L.
Published: January 2023

This study aims to determine the effect of the use of local microorganisms (moles) in the silage of cow rumen contents on the digestibility of dry matter, organic matter and total digestible nutrients (TDN) in vitro. The method used in this study was an experimental method using a complete randomized design (CRD) consisting of four treatments of four replicates. The treatment is P0 = 60% rumen contents + 35% rice bran + 5% sugar; P1 = P0 + 40 ml Mole; P2 = P0 + 80 ml Mole; P3 = P0 + 120 ml Mole. The variables measured were dry matter, organic matter digestibility and total digestible nutrient (TDN). The data were analyzed using Analysis of Variance (Anova) and if there were differences among the treatments with Duncan's range test. Statistical analysis show that there were significant difference (P<0.01) on dry matter and organic matter digestibility and total digestible nutrients (TDN). The conclusion showed that the use 40 ml of local microorganisms was the best level to increase dry and organic matter digestibility and total digestible nutrients. 

 

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan mikroorganisme lokal (mol) dalam silase isi rumen sapi terhadap kecernaan bahan kering, bahan organik dan total digestible nutrient (TDN) secara in vitro. Metode yang digunakan adalah metode eksperimen dengan menggunakan rancangan acak lengkap (RAL) terdiri dari 4 perlakuan 4 ulangan. Perlakuannya yaitu P0 = 60% isi rumen + 35% dedak + 5% gula; P1 = P0 + 40 ml Mol; P2 = P0 + 80 ml Mol; P3= P0 + 120 ml Mol. Variabel yang diukur adalah kecernaan bahan kering, bahan organik dan total digestible nutrient (TDN). Data dianalisis menggunakan Analysis of Variance (Anova) dan dilanjutkan dengan uji jarak berganda Duncan. Hasil analisis statistik menunjukkan perlakuan berpengaruh sangat nyata (P<0,01) terhadap kecernaan bahan kering, bahan organik dan total digestible nutrient (TDN). Hasil uji jarak bergandan Duncan menunjukkan perlakuan yang menggunakan mikroorganisme lokal (mol) berbeda sangat nyata dibandingkan dengan perlakuan kontrol. Disimpulkan bahwa penggunaan level mikroorganisme lokal pada silase isi rumen dapat meningkatkan KcBK, KcBO dan TDN. Perlakuan terbaik adalah penggunaan mikroorganisme lokal 40 ml.
An Overview on Low Back Pain and Functional Disability: Associated Risk Factors and Management
Authors: Abdelbasset Walid Kamal , Sulieman Abdelmoneim
Published: January 2023

Recently, low back pain (LBP) has been a major contributor to disability worldwide. Chronic LBP affects 80% of the population at some point. The incidence of LBP is on the rise, especially among the elderly, and it is more common in men than in women. The different aspects of one’s life, such as a history of mental illness, being overweight, smoking, not getting enough exercise, getting older, and leading a sedentary lifestyle, all increase the likelihood of developing LBP. According to research, there are a number of causes and contributing factors that add up to a hefty price tag for disabled people. Functional disability in chronic LBP can be caused in part by causes other than the disease itself, such as psychological and professional variables, and can put restrictions on one’s personal life, work life, and family life. According to a recent study, more than 80% of those with a functional disability were classified as having a moderate-to-severe impairment. Therefore, we have proposed this review to clarify the appropriate assessment and interventional modalities for LBP and reduce disability. The diagnosis of LBP may need physical examination as well as imaging procedures to rule out the possibility of other ailments, such as broken bones. There is more than one technique to treat the underlying causes of LBP. Interventions include several modalities, including medication, physical therapy, manual therapy, injections, and surgery. In terms of pain treatment, we could choose between over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) and prescribed drugs. Back spasms can be treated with other medications that relax the muscles in the back. Physiotherapy can help an individual build up the core muscles that protect the spine. Physical therapy can help individuals to stay injury-free by doing more than just increasing the range of motion. Tense muscles can be relaxed, pain can be lessened, and posture and alignment can be enhanced through a series of sessions.
Personal Branding: Membangun Karakter Melalui Content Writing Berbasis Media Sosial
Authors: Musrifah
Published: January 2023

Dalam era komunikasi digital saat ini, siapapun sepakat media sosial memiliki pengaruh besar dalam banyak hal. Salah satunya untuk membangun personal branding. Dalam konteks komunikasi pemasaran, branding dikenal sebagai cara untuk membentuk persepsi positif publik atas produk tertentu sehingga mendorong keputusan pembelian dan terjadinya transaksi.

Menariknya, branding kini bukan hanya giat dilakukan oleh korporat, institusi, dan pebisnis, tapi juga oleh individu untuk membentuk identitas dan membangun karakter pribadi seseorang. Aktivitas ini yang kemudian dikenal dengan nama: personal branding.

Penulis mendapati beberapa strategi content writing yang dapat dipraktikkan dalam membangun personal branding. Strategi content writing tersebut peneliti sebut sebagai : Showing, Telling, Personal Selling, Adapting, dan Understanding.
Authenticity and the (in)visibility of service user representation
Authors: Clarke Simon , Jones Nev , Mordecai David
Published: January 2023

INTERVIEW
Entre homonimia y polisemia. La identificación del significante y la definición de los significados.
Authors: García-Hernández Benjamín
Published: January 2023

Los criterios de análisis lexicológico contribuyen a mejorarlos métodos de elaboración lexicográfica, tanto en el aspecto morfológicocomo en el semántico. La estructura de oposición privativa en particularpuede precisar la definición de sinónimos (río, arroyo, regato).La investigación etimológica es imprescindible para evitar la confusiónde homónimos (varios sufijos -ato), para revelar la compleja identidadhistórica de regato, rego, riego, riega, reguero, reguera, regajo, regacho,asociados tradicionalmente a regar, o para establecer el parentesco entreius (‘derecho’) y ius (‘salsa’), entendidos hasta ahora como homónimos.Finalmente, consideramos útil insertar en diccionarios especiales y léxicosde autor los homónimos y polisemas que se atestiguan de forma indirectaen contextos de ambigüedad intencional.
Nomdedeu, Antoni: Diccionario de Fútbol, Anexos de la Revista de Lexicografía, 11, A Coruña, 2009.
Authors: Iglesia Martín Sandra
Published: January 2023

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Con el pretexto de la publicación de Procesos de formación y cambio en las llamadas «palabras gramaticales» de la profesora Rosa María Espinosa Elorza
Authors: Sánchez Santiago U.
Published: January 2023

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Hacia una edición crítica del «vocabulario en seis lenguas» del Libro de los secretos de agricultura de Miguel Agustín
Authors: Pablo Núñez Luis
Published: January 2023

Este artículo aborda la edición del «Vocabulario en seis lenguas» que aparece como apéndice al final del Libro de los secretos deagricultura (1617, 1626) de Miguel Agustín. Tras la determinación de susediciones más significativas y de las variantes en ellas contenidas, se estableceuna versión depurada del texto, seguida de varios índices alfabéticos.Se realizan también algunas observaciones sobre los problemas de ediciónde los diccionarios del Siglo de Oro.
Los límites del léxico especializado: la terminología de los gramáticos latinos
Authors: Uría Javier
Published: January 2023

En este artículo se exponen algunos problemas que se planteanen la delimitación de la terminología técnica, ejemplificados enel léxico de la gramática latina antigua. Partiendo de dos distincionesbásicas, la de metalenguaje y terminología gramatical, y la de significacióny designación, se abordan aspectos como: 1) los problemas dedelimitación del corpus, que comporta diferentes niveles de densidadtécnica; 2) la identificación de los conceptos técnicos y su adscripción adiferentes clases de palabras; 3) la imbricación del vocabulario técnicocon la lengua común y su función comunicativa, que explica aparentesdeficiencias de las terminologías; 4) la aportación del análisis sémico alcenso de términos técnicos; 5) la importancia de las relaciones de hiperonimiae hiponimia en la configuración de las terminologías; 6) los tiposde sinonimias terminológicas.
Juan de Valdés, humanista y lingüista
Authors: Monreal Pérez Juan Luis
Published: January 2023

Juan de Valdés debe ser incluido en la lista de humanistas españolesrelevantes, en cuanto que su trayectoria personal y de hombre deletras está marcada por un claro humanismo, cultivando todos los valorespropios de esta corriente. La lengua y la literatura siempre fueron paraValdés elementos permanentes en su cultura humanista contribuyendo especialmenteal desarrollo de la lengua española mediante su obra principalel Diálogo de la lengua. Precisamente, la perspectiva humanista-renacentistaque impregna toda la obra de Valdés le lleva a tratar los problemaslingüísticos desde dicha orientación. Ello explica que este texto filológicoresponda a lo que se ha llamado la ideología renacentista.
Seminario modular sobre la preservación digital, edición y estudio filológico de documentos hispánicos
Authors: Grande López Clara
Published: January 2023

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Lexicon nauticum et aquatile
Authors: García Aranda M.ª Ángeles
Published: January 2023

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Francisco de Osuna y la imprenta
Authors: Madroñal Abraham
Published: January 2023

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ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma
Authors: Morgan Kimberly J , Doggett Karen , Geng Fansuo , Mieruszynski Stephen , Whitehead Lachlan , Smith Kelly A , Hogan Benjamin M , Simons Cas , Baillie Gregory J , Molania Ramyar , Papenfuss Anthony T , Hall Thomas E , Ober Elke A , Stainier Didier YR , Gong Zhiyuan , Heath Joan K
Published: January 2023

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using both larval and adult zebrafish models of hepatocellular carcinoma (HCC), in which the expression of an inducible mutant kras transgene (krasG12V) drives hepatocyte-specific hyperplasia and liver enlargement, we show that reducing ahctf1 gene dosage by 50% markedly decreases liver volume, while non-hyperplastic tissues are unaffected. We demonstrate that in the context of cancer, ahctf1 heterozygosity impairs nuclear pore formation, mitotic spindle assembly, and chromosome segregation, leading to DNA damage and activation of a Tp53-dependent transcriptional programme that induces cell death and cell cycle arrest. Heterozygous expression of both ahctf1 and ranbp2 (encoding a second nucleoporin), or treatment of heterozygous ahctf1 larvae with the nucleocytoplasmic transport inhibitor, Selinexor, completely blocks krasG12V-driven hepatocyte hyperplasia. Gene expression analysis of patient samples in the liver hepatocellular carcinoma (LIHC) dataset in The Cancer Genome Atlas shows that high expression of one or more of the transcripts encoding the 10 components of the NUP107–160 subcomplex, which includes AHCTF1, is positively correlated with worse overall survival. These results provide a strong and feasible rationale for the development of novel cancer therapeutics that target ELYS function and suggest potential avenues for effective combinatorial treatments.
Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders
Authors: Burglen Lydie , Van Hoeymissen Evelien , Qebibo Leila , Barth Magalie , Belnap Newell , Boschann Felix , Depienne Christel , De Clercq Katrien , Douglas Andrew GL , Fitzgerald Mark P , Foulds Nicola , Garel Catherine , Helbig Ingo , Held Katharina , Horn Denise , Janssen Annelies , Kaindl Angela M , Narayanan Vinodh , Prager Christina , Rupin-Mas Mailys , Afenjar Alexandra , Zhao Siyuan , Ramaekers Vincent Th , Ruggiero Sarah M , Thomas Simon , Valence Stéphanie , Van Maldergem Lionel , Rohacs Tibor , Rodriguez Diana , Dyment David , Voets Thomas , Vriens Joris
Published: January 2023

TRPM3 is a temperature- and neurosteroid-sensitive plasma membrane cation channel expressed in a variety of neuronal and non-neuronal cells. Recently, rare de novo variants in TRPM3 were identified in individuals with developmental and epileptic encephalopathy, but the link between TRPM3 activity and neuronal disease remains poorly understood. We previously reported that two disease-associated variants in TRPM3 lead to a gain of channel function . Here, we report a further 10 patients carrying one of seven additional heterozygous TRPM3 missense variants. These patients present with a broad spectrum of neurodevelopmental symptoms, including global developmental delay, intellectual disability, epilepsy, musculo-skeletal anomalies, and altered pain perception. We describe a cerebellar phenotype with ataxia or severe hypotonia, nystagmus, and cerebellar atrophy in more than half of the patients. All disease-associated variants exhibited a robust gain-of-function phenotype, characterized by increased basal activity leading to cellular calcium overload and by enhanced responses to the neurosteroid ligand pregnenolone sulfate when co-expressed with wild-type TRPM3 in mammalian cells. The antiseizure medication primidone, a known TRPM3 antagonist, reduced the increased basal activity of all mutant channels. These findings establish gain-of-function of TRPM3 as the cause of a spectrum of autosomal dominant neurodevelopmental disorders with frequent cerebellar involvement in humans and provide support for the evaluation of TRPM3 antagonists as a potential therapy.
FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
Authors: Liu Cong , Schönke Milena , Spoorenberg Borah , Lambooij Joost M , van der Zande Hendrik JP , Zhou Enchen , Tushuizen Maarten E , Andreasson Anne-Christine , Park Andrew , Oldham Stephanie , Uhrbom Martin , Ahlstedt Ingela , Ikeda Yasuhiro , Wallenius Kristina , Peng Xiao-Rong , Guigas Bruno , Boon Mariëtte R , Wang Yanan , Rensen Patrick CN
Published: January 2023

Analogues of the hepatokine fibroblast growth factor 21 (FGF21) are in clinical development for type 2 diabetes and nonalcoholic steatohepatitis (NASH) treatment. Although their glucose-lowering and insulin-sensitizing effects have been largely unraveled, the mechanisms by which they alleviate liver injury have only been scarcely addressed. Here, we aimed to unveil the mechanisms underlying the protective effects of FGF21 on NASH using APOE*3-Leiden.CETP mice, a well-established model for human-like metabolic diseases. Liver-specific FGF21 overexpression was achieved in mice, followed by administration of a high-fat high-cholesterol diet for 23 weeks. FGF21 prevented hepatic lipotoxicity, accompanied by activation of thermogenic tissues and attenuation of adipose tissue inflammation, improvement of hyperglycemia and hypertriglyceridemia, and upregulation of hepatic programs involved in fatty acid oxidation and cholesterol removal. Furthermore, FGF21 inhibited hepatic inflammation, as evidenced by reduced Kupffer cell (KC) activation, diminished monocyte infiltration, and lowered accumulation of monocyte-derived macrophages. Moreover, FGF21 decreased lipid- and scar-associated macrophages, which correlated with less hepatic fibrosis as demonstrated by reduced collagen accumulation. Collectively, hepatic FGF21 overexpression limits hepatic lipotoxicity, inflammation, and fibrogenesis. Mechanistically, FGF21 blocks hepatic lipid influx and accumulation through combined endocrine and autocrine signaling, respectively, which prevents KC activation and lowers the presence of lipid- and scar-associated macrophages to inhibit fibrogenesis.
Neural assemblies uncovered by generative modeling explain whole-brain activity statistics and reflect structural connectivity
Authors: van der Plas Thijs L , Tubiana Jérôme , Le Goc Guillaume , Migault Geoffrey , Kunst Michael , Baier Herwig , Bormuth Volker , Englitz Bernhard , Debrégeas Georges
Published: January 2023

Patterns of endogenous activity in the brain reflect a stochastic exploration of the neuronal state space that is constrained by the underlying assembly organization of neurons. Yet, it remains to be shown that this interplay between neurons and their assembly dynamics indeed suffices to generate whole-brain data statistics. Here, we recorded the activity from ∼40,000 neurons simultaneously in zebrafish larvae, and show that a data-driven generative model of neuron-assembly interactions can accurately reproduce the mean activity and pairwise correlation statistics of their spontaneous activity. This model, the compositional Restricted Boltzmann Machine (cRBM), unveils ∼200 neural assemblies, which compose neurophysiological circuits and whose various combinations form successive brain states. We then performed in silico perturbation experiments to determine the interregional functional connectivity, which is conserved across individual animals and correlates well with structural connectivity. Our results showcase how cRBMs can capture the coarse-grained organization of the zebrafish brain. Notably, this generative model can readily be deployed to parse neural data obtained by other large-scale recording techniques.
Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
Authors: Brown Tanya L , Horton Emma C , Craig Evan W , Goo Camille EA , Black Erik C , Hewitt Madeleine N , Yee Nathaniel G , Fan Everett T , Raible David W , Rasmussen Jeffrey P
Published: January 2023

Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex. Development and patterning of Merkel cells and associated neurites during skin organogenesis remain poorly understood, partly due to the in utero development of mammalian embryos. Here, we discover Merkel cells in the zebrafish epidermis and identify Atonal homolog 1a (Atoh1a) as a marker of zebrafish Merkel cells. We show that zebrafish Merkel cells derive from basal keratinocytes, express neurosecretory and mechanosensory machinery, extend actin-rich microvilli, and complex with somatosensory axons, all hallmarks of mammalian Merkel cells. Merkel cells populate all major adult skin compartments, with region-specific densities and distribution patterns. In vivo photoconversion reveals that Merkel cells undergo steady loss and replenishment during skin homeostasis. Merkel cells develop concomitant with dermal appendages along the trunk and loss of Ectodysplasin signaling, which prevents dermal appendage formation, reduces Merkel cell density by affecting cell differentiation. By contrast, altering dermal appendage morphology changes the distribution, but not density, of Merkel cells. Overall, our studies provide insights into touch system maturation during skin organogenesis and establish zebrafish as an experimentally accessible in vivo model for the study of Merkel cell biology.
Differential expression of lysine acetylation proteins in gastric cancer treated with a new antitumor agent bioactive peptide chelate selenium
Authors: Xu Yanan , Wen Jianxun , Han Wenyan , Yan Jin , Jia Wei , Su Xiulan
Published: January 2023

The method of anticancer bioactive peptide (ACBP) functionalized selenium particle (Se), which has enhanced anticancer activity, inhibited the growth of gastric cancer (GC) cells, and increased the ability of apoptosis in vitro, has been reported in previous studies. We used tandem mass spectrometry (TMT) labeling to construct a complete atlas of the acetylation-modified proteome in GC MKN-45 cells treated with ACBP-Se. The proteomics data database was searched and analyzed by bioinformatics: Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), functional enrichment, and protein-protein interaction network. Finally, we conducted a quantitative PRM analysis of the selected target-modified peptides. We identified 4,958 acetylation sites from 1,926 proteins in this research. Among these, 4,467 acetylation sites corresponding to 1,777 proteins were quantified. Based on the above data and standards, we found that in the ACBP-Se group vs. the control group, 297 sites were upregulated, and 665 sites were downregulated. We systematically assessed the proteins containing quantitative information sites, including protein annotation, functional classification, and functional enrichment, cluster analysis supported by functional enrichment, domain structures, and protein interaction networks. Finally, we evaluated differentially expressed lysine acetylation sites. We revealed that SHMT2 K200 and PGK1 K97 were the most critical acetylated non-histone proteins, which may have an essential role in ACBP-Se treatment. Here, we identified and quantified the lysine acetylation proteins in GC cells treated with ACBP-Se. The characterization of acetylation indicates that acetylated proteins might be pivotal in the biological process, molecular binding, and metabolic pathways of ACBP-Se treatment progress. Our findings provide a broad understanding of acetylation ACBP-Se treatment of GC, suggesting a potential application for molecular targeted therapy.
Nitrogen and potassium interactions optimized asynchronous spikelet filling and increased grain yield of japonica rice
Authors: Xu Weitao , Li Jianming , Feng Jiancheng , Shao Zhenzhu , Huang Yidan , Hou Wenfeng , Gao Qiang
Published: January 2023

Poor grain filling severely reduces rice yield. Fertilizers play a vital role in regulating grain filling, especially nitrogen (N) and potassium (K). In this field study we aimed to investigate the interactive effects of N and K on the asynchronous filling properties of superior and inferior spikelets of japonica rice. We looked at grain filling under three N rates (0, 90, and 180 kg N ha−1) and three K rates (0, 60, and 120 kg K2O ha−1) during 2020 and 2021. Across two years, the results showed that the combined use of N and K on superior and inferior spikelets significantly increased their weight by 1.29 mg and 2.31 mg, their maximum grain filling rate by 0.24 mg d−1 and 0.07 mg d−1, and their average grain filling rate by 0.21 mg d−1 and 0.06 mg d−1, respectively, in comparison with the control (N0K0) treatment. Likewise, K supply increased the average contribution rate of superior and inferior spikelets to yield by 9.1% and 10.0%, respectively. Correlation analysis showed that the grain filling rate of superior and inferior spikelets was an important factor in determining the spikelet weight, whereas the grain filling time was not. We also found that the 1,000-grain weight mainly increased after increasing the spikelets’ maximum grain filling rate and average grain filling rate. Collectively, these results illustrate that the combined use of N and K can optimize the asynchronous filling of superior and inferior spikelets and, in particular, enhance inferior spikelet weight with higher rice yield.
Gêneros do Istmo
Authors: Baena Pâmela Keiti , Lana Rita de Cássia
Published: January 2023

Em Juchitán de Zaragoza, cidade mexicana da região do Istmo de Tehuantepec, há o que se convencionou chamar de ‘terceiro gênero’, as muxes. Com o objetivo de discutir a possibilidade de existência de um espaço de gênero não binário em sociedades não-ocidentais, colocou-se a questão: o que as muxes podem informar sobre a possibilidade de se pensar sob uma perspectiva de gênero menos binarista? Para isso, tomou-se como base teórico-metodológica a concepção de Henri Lefebvre sobre a produção do espaço e suas três dimensões conceituais: a prática espacial; as representações do espaço; e os espaços de representação. Por meio de uma reconstituição historiográfica do espaço geográfico, da condição das mulheres e da construção da identidade muxe, concluiu-se que o espaço produzido pelos corpos muxes é um espaço diferencial que resiste às imposições coloniais, negocia com os discursos das mídias, dialoga com os espaços acadêmicos e emerge como questionamento às forças que tentam ocultá-los.
Reinvenção dos corpos trans interioranos
Authors: Bitencourt Kueyla Andrade , Ferreira dos Santos João Diógenes
Published: January 2023

Este artigo propõe discutir sobre a potência criativa do processo de reinvenção dos corpos trans interioranos. Buscou-se problematizar o território interiorano, desde a perspectiva decolonial, com vistas a apresentar processos de singularização de corpos dissidentes que transitam e afirmam sua existência fronteiriça desde esses locais. Assim, será apresentada a experiência de Tieta, travesti que agenciou táticas insurgentes diante das condições de extrema vulnerabilidade a que estiveram expostas as pessoas trans em Vitória da Conquista, cidade do interior da Bahia, na pandemia de covid-19. Afirma-se que, os corpos trans interioranos, em sua potência disruptiva, tornam possível a composição de novas territorialidades e de práticas de liberdade ao se deslocarem das normatividades. Além disso, elaboram outras expressões criativas, novos vínculos afetivos e sexuais, saberes inéditos, e reinventam suas existências em torno de modos de vida comuns.
Anatomy From Nazi Germany to Today
Authors: Hildebrandt Sabine
Published: January 2023

This viewpoint reviews the anatomical body procurement used in Nazi Germany, notes the continued use of those images, and calls for disclosure of the biographical history of the people whose bodies and tissues are now studied.
Prevalence of Colorectal Neoplasia 10 or More Years After a Negative Screening Colonoscopy in 120 000 Repeated Screening Colonoscopies
Authors: Heisser Thomas , Kretschmann Jens , Hagen Bernd , Niedermaier Tobias , Hoffmeister Michael , Brenner Hermann
Published: January 2023

Importance

Screening colonoscopy to prevent and early detect colorectal cancer is recommended to be repeated in 10-year intervals, which goes along with high demands of capacities and costs. Evidence of findings at screening colonoscopies conducted 10 or more years after a negative colonoscopy result is sparse, and it remains unclear whether screening colonoscopy intervals could possibly be prolonged.

Objective

To assess the prevalence of advanced colorectal neoplasms (ADNs) at least 10 years after a negative screening colonoscopy in a very large cohort of repeated screening colonoscopy participants in Germany.

Design, Setting, and Participants

This registry-based cross-sectional study on screening colonoscopy findings reported to the German screening colonoscopy registry during January 2013 to December 2019 included data on screening colonoscopies that were offered to the German general population 55 years or older since 2002; virtually all screening colonoscopies among individuals covered by Statutory Health Insurance (approximately 90% of eligible adults) are reported to the national registry. A total of 120 298 repeat screening colonoscopy participants 65 years or older were identified who had a previous negative screening colonoscopy at least 10 years prior. The findings were compared with all screening colonoscopies conducted at 65 years or older during the same period (1.25 million). The data were analyzed from March to July 2022.

Main Outcomes and Measures

Prevalence of colorectal cancers and ADNs (advanced adenomas and cancers).

Results

Of 120 298 participants, 72 349 (60.1%) were women. Prevalence of ADN was 3.6% and 5.2% among women and men 10 years after a negative screening colonoscopy and gradually increased to 4.9% and 6.6%, respectively, among those who had a negative colonoscopy 14 years or longer prior compared with 7.1% and 11.6% among all screening colonoscopies. Sex-specific and age-specific prevalence of ADNs at repeated colonoscopies conducted 10 or more years after a negative colonoscopy were consistently at least 40% lower among women than among men, lower at younger vs older ages, and much lower than among all screening colonoscopies (standardized prevalence ratios for cancers: 0.22-0.38 among women, 0.15-0.24 among men; standardized prevalence ratios for ADNs: 0.49-0.62 among women, 0.50-0.56 among men).

Conclusions and Relevance

The results of this cross-sectional study suggest that ADN prevalence at screening colonoscopies conducted 10 or more years after a negative screening colonoscopy is low. Extension of the currently recommended 10-year screening intervals may be warranted, especially for female and younger participants without gastrointestinal symptoms.
Longitudinal Developmental Outcomes of Infants and Toddlers With Traumatic Brain Injury
Authors: Keenan Heather T. , Clark Amy , Holubkov Rich , Ewing-Cobbs Linda
Published: January 2023

Importance

Among children, infants and toddlers have some of the highest rates of traumatic brain injury (TBI), but longitudinal information on their developmental outcomes to guide postinjury surveillance is sparse.

Objective

To evaluate infants’ and toddlers’ development over 3 years following TBI compared with those with orthopedic injury (OI).

Design, Setting, and Participants

A longitudinal observational cohort study was conducted at 2 level 1 pediatric trauma centers from January 20, 2013, to September 30, 2015; data analysis was performed from May 12 to October 20, 2021. Participants included children injured when younger than 31 months with TBI or OI who received emergency department care.

Exposures

Mild, moderate, or severe TBI or OI.

Main Outcomes and Measures

Parents completed baseline measures representing preinjury status and 3-, 12-, 24-, and 36-month postinjury status, using the Ages & Stages Questionnaire-3 (ASQ-3), with a mean reference value of 50 and higher scores indicating more advanced development. Linear mixed models characterized children’s outcomes for each ASQ-3 domain after adjustment for baseline ASQ-3, injury severity and group, age, injury mechanism (abuse or not), sex, prematurity, family function, social capital, and time. Interactions with time were evaluated.

Results

Consent for participation was provided for 195 children; 184 parents (94%) completed a baseline survey. The cohort included 168 children who completed at least 1 follow-up survey: 48 (29%) mild; 54 (32%) complicated mild/moderate; 21 (13%) severe TBI; and 45 (27%) orthopedic injury. The cohort included 95 boys (57%), 49% injured before age 1 year; and 13% injured by abuse. Mean (SD) age at the time of injury was 13.9 (9.4) months. At 36 months, children with mild or complicated mild/moderate TBI performed similarly to children with OI across ASQ-3 domains. Children with severe TBI performed poorly as shown by negative mean differences in communication (–8.8; 95% CI, –13.8 to –3.8); gross motor (–10.1; 95% CI, –15.1 to –5.1); problem solving (–6.6; 95% CI, –11.2 to –1.9), and personal social (–6.3; 95% CI, –10.4 to –2.1) domains with little recovery over time. Children with abusive injury experienced decrements in ability over time in fine motor and personal social skills. Social capital was protective in communication (mean, 1.5; 95% CI, 0.3-2.7) and problem solving (mean, 1.2; 95% CI, 0.1-2.3) domains.

Conclusions and Relevance

In this cohort study of children with TBI, children with severe injury showed little recovery. These findings suggest that early childhood intervention is needed, while children with milder injury remained on their developmental track and should continue routine developmental surveillance.