bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating the Construct Validity of the Charité Alarm Fatigue Questionnaire using Confirmatory Factor Analysis
Authors: Wunderlich Maximilian Markus , Krampe Henning , Fuest Kristina , Leicht Dominik , Probst Moriz Benedikt , Runge Julian , Schmid Sebastian , Spies Claudia , Weiß Björn , Balzer Felix , Poncette Akira-Sebastian
Published: January 2024

Background. The Charité Alarm Fatigue Questionnaire (CAFQa) is a 9-item Questionnaire that aims to standardize how alarm fatigue (AF) in nurses and physicians is measured. We previously hypothesized that it has two correlated scales, i.e. one on the psychosomatic effects of AF and the other on staff’s coping strategies in working with alarms.
Objective. We aimed to validate the hypothesized structure of the CAFQa and thus underpin the instrument's construct validity.
Methods. We conducted two independent studies with nurses and physicians from ICUs in Germany (NStudy 1 = 265, NStudy 2 = 1212). Responses to the questionnaires were analyzed using confirmatory factor analysis with the unweighted least-squares algorithm based on polychoric covariances. Convergent validity was assessed by participants' estimation of their own AF and exposure to false alarms in percent.
Results. In both studies the chi-square test reached statistical significance (ꭓ2(26) = 44.932, p = 0.012 and ꭓ2(26) = 92.416, p < 0.001 for Study 1 and 2, respectively). Other fit indices suggested a good model fit (in both studies RMSEA < 0.05, SRMR < 0.08, RNI > 0.95, TLI > 0.95, and CFI > 0.995). Participants' mean scores correlated moderately with self-reported AF (rStudy 1 = 0.45; rStudy 2 = 0.53) and weakly with self-perceived exposure to false alarms (rStudy 1 = 0.3; rStudy 2 = 0.33).
Conclusion. The questionnaire measures the construct of alarm fatigue as proposed in our previous study. Researchers and clinicians can rely on the CAFQa to measure the AF of nurses and physicians.
Inter-Organizational Alignment and Implementation Outcomes in Integrated Mental Healthcare for Children and Adolescents: A Cross-Sectional Observational Study
Authors: Zhang Yanchen , Larson Madeline , Ehrhart Mark G. , King Kevin , Lyon Aaron R. , Locke Jill , Cook Clayton
Published: January 2024

Background: Integrated care involves care provided by a team of professionals, often in non-traditional settings. A common example worldwide is integrated school-based mental health (SBMH), which involves externally employed clinicians providing care at schools. Integrated mental healthcare can improve the accessibility and efficiency of evidence-based practices (EBPs) for vulnerable populations suffering from fragmented traditional care. However, integration can complicate EBP implementation due to overlapping organizational contexts, diminishing the public health impact. Emerging literature suggests that EBP implementation may benefit from the similarities in the implementation context factors between the different organizations in integrated care, which we termed inter-organizational alignment (IOA). This study quantitatively explored whether and how IOAs in general and implementation context factors are associated with implementation outcomes in integrated SBMH.
Methods: SBMH clinicians from community-based organizations (CBOs; nclinician=27) and their proximal student-support school staff (nschool=99) rated their schools and CBOs (clinician only) regarding general (organizational culture and molar climate) and implementation context factors (Implementation Climate and Leadership), and nine common implementation outcomes (e.g., treatment integrity, service access, acceptability). The levels of IOA were estimated by intra-class correlations (ICCs). We fitted multilevel models to estimate the standalone effects of context factors from CBOs and schools on implementation outcomes. We also estimated the 2-way interaction effects between CBO and school context factors (i.e., between-setting interdependence) on implementation outcomes.
Results: The IOA in general context factors exceeded those of implementation context factors. The standalone effects of implementation context factors on most implementation outcomes were larger than those of general context factors. Similarly, implementation context factors between CBOs and schools showed larger 2-way interaction effects on implementation outcomes than general context factors.
Conclusions: This study preliminarily supported the importance of IOA in context factors for integrated SBMH. The findings shed light on how IOA in implementation and general context factors may be differentially associated with implementation outcomes across a broad array of integrated mental healthcare settings.
A Comparative Analysis Between Intraoperative Fluorescein Sodium Videoangiography and Postoperative Imaging for Evaluating Clipped Intracranial Aneurysms
Authors: Dellaretti Marcos , Soares André Guimarães , Lima Allan Douglas de Oliveira , de Melo Matheus Tavares , Acherman Natalia Dilella , de Almeida Júlio Cesar , Gonçalves Vitor de Deus da Rocha Ribeiro , Costa Bruno Silva
Published: January 2024

Comparing the findings of intraoperative fluorescein sodium videoangiography (FL-VA) and post operative Computed Tomography Angiography (CTA), this study aims to assess whether FL-VA is a suitable modality for intraoperative evaluation of aneurysmal obliteration and the patency of parent and adjacent vessels. This study is an observational prospective analysis focused on patients who underwent surgery for aneurysms at the Department of Neurosurgery, Santa Casa BH, Belo Horizonte, Minas Gerais, from December 2021 to September 2022. Postoperative CTA was conducted in 54 patients (61 aneurysms). The results of the CTA revealed complete occlusion in 51 out of the 61 aneurysms, accounting for 83.6% of the cases. FL-VA revealed complete occlusion in 93.4% of the studied aneurysms (57 out of 61). Ten cases of discordance between FL-VA and CTA were identified: One patient was indicated as a neck remnant in FL-VA, but CT angiography revealed a residual aneurysm; one patient CT angiography showed neck remnant and stenosis in branching vessels, that it was not identified by FL-VA; five aneurysms had neck remnants, and three cases had stenosis in branching vessels, which were not observed in FL-VA but were detected in CTA. No studied factor showed significant association with the discordance observed between FL-VA and CT angiography. The results of this study contribute to the increasing evidence that supports FL-VA as a highly valuable modality for the intraoperative assessment of aneurysmal obliteration and the patency of parent and adjacent vessels
A fault diagnosis technique based on Multi-domain Features and RelifF-Bayes-KNN
Authors: Wang Bing , Xiong Hu
Published: January 2024

In order to improve the fault diagnosis efficiency of rotating mechanisms such as rolling bearings, a fault diagnosis model based on multi-domain features and RelifF feature selection-Bayesian optimized K nearest neighbor (abbreviated as MDF-Relief-Bayes-KNN) is proposed in this paper. Firstly, processing fine-grained multi-scale analysis (abbreviated as FGMA) on the vibration signal and extracting fine-grained multi-scale sample entropy (abbreviated as FGMSE) to characterize the nonlinear complexity characteristics in multi-scale quantitatively. Then, multi-dimensional time-domain features are extracted to quantitatively describe the time-domain statistical features of the signal. Multi-domain features are constructed by combining the two types of features. Considering information redundancy in multi-domain features, ReliefF method is introduced for feature selection and a simplified feature vector is obtained. Bayesian Optimization (abbreviated as BO) is imported to optimize the distance type and k (the nearest neighbors’ number) of k-Nearest Neighbor (abbreviated as KNN) model, and Bayes-KNN fault diagnosis model is established. An instance analysis on Case Western Reserve University rolling bearing dataset shows that the average 10-folders CV accuracy of the proposed technique can reach 99.24%. The selection of feature vectors is also scientific and effective when adopting different features. Compared with different fault diagnosis models such as Support vector machine (abbreviated as SVM), Naive Bayes (abbreviated as NB), Binary classification decision tree (abbreviated as BDT) and Linear discriminant analysis (abbreviated as LDA), the proposed technique has high accuracy and calculation speed, and it is a kind of fault diagnosis method with potential application.
Association between systemic immune-inflammation index and psoriasis: A cross-sectional study
Authors: Bo Yang , Zhong Xiaojing , Ren Qingjun , Xiang Yanping , Luo Nana , Chen Xingyin , Ma Zuchao , Hao Pingsheng
Published: January 2024

Objectives
The Systemic Immune-inflammatory Index (SII), an emergent biomarker for inflammation, has recently garnered attention. Psoriasis, characterized by its immune-inflammatory nature, presents an intriguing domain for exploring potential associations with SII. This investigation is poised to unravel the complexities of this relationship.
Methods
Leveraging data from the National Health and Nutrition Examination Survey (NHANES), spanning five distinct cycles (2003–2004, 2005–2006, 2009–2010, 2011–2012, and 2013–2014), this cross-sectional study meticulously calculated the SII, taking into account lymphocyte, neutrophil, and platelet counts. Questionnaire data from individuals with psoriasis were meticulously analyzed. An array of statistical methodologies was employed to discern the linear and non-linear relationships between SII and psoriasis, including multivariate regression, subgroup analyses, smoothed curve fitting, and threshold effect analyses.
Results
Encompassing a demographic of 23,825 Americans, this population-based study identified 623 individuals (2.61%) with psoriasis. Following a rigorous adjustment for pivotal covariates such as age, gender, and race, multivariate logistic regression analyses unveiled a significant and positive correlation between SII and psoriasis (OR = 1.14, 95% CI = 1.01–1.29, P = 0.0286), with the interaction test demonstrating robustness in this association. Intriguingly, the relationship between SII and psoriasis was elucidated to be non-linear, as evidenced by a two-stage linear regression model, pinpointing an inflection point at 790.4 (1,000 cells/l).
Conclusion
The present study establishes an independent association between a self-reported history of psoriasis and SII. Moreover, it delineates SII as an independent risk factor for psoriasis at levels below 790.4 (1,000 cells/l), thereby contributing valuable insights into the immunological landscape of psoriasis.
The co-occurrence of sarcoidosis and anti-PLA2R-associated membranous nephropathy in a patient with underlying genetic susceptibility
Authors: DING Ying , Li WAN , Qu Zhen , Yu Feng
Published: January 2024

Background
Sarcoidosis is a multisystemic inflammatory disease, characterized by the presence of non-caseating, epithelioid granulomas. Glomerular disease in patients with sarcoidosis is rare and membranous nephropathy (MN) is cited as the most common. The association between the two diseases remained unclear. This article reported a case of co-occurrence of sarcoidosis and anti-PLA2R-associated MN, to provide a possible relationship between these two entities.
Patient concerns:
A 61-year-old Chinese Han woman with a history of sarcoidosis was admitted to our hospital for nephrotic syndrome (NS).
Diagnosis:
Her sarcoidosis was diagnosed according to the adenopathy observed on the computed tomography (CT) scan and the biopsy of the right supraclavicular lymph node. The MN presented with nephrotic syndrome with a PLA2R antibody titer of 357RU/ml, and the final diagnosis was based on a renal biopsy.
Intervention:
The patient’s sarcoidosis was remitted after treatment with prednisone. One year later MN was diagnosed, and she was treated with prednisone combined with calcineurin inhibitors, based on a full dose of renin-angiotensin system (RAS) inhibitor.
Outcomes:
The patient's sarcoidosis had been in remission while the MN was recurrent, and her renal function deteriorated to end-stage renal disease 6 years later due to discontinuation of immunosuppression. A genetic test led to identifying the HLA-DRB1*0301 and HLA-DRB1*150 genes associated with both sarcoidosis and MN, which provides a possible explanation of the co-occurrence of these two diseases.
Conclusion
This case suggested for the first time a potential genetic connection between idiopathic MN and sarcoidosis which needs further studies in the future.
A 2BS cell adapted China fixed rabies virus vaccine strain 2aG4-B40 and its application prospect in human rabies vaccine
Authors: Xu Ying , Weng Lin , Wang Xuan , Li Ming , Guo Wanping , Liu Yiqing , Li Xiang , Wang Zhenping , Liu Xinyu , Xu Shengnan , He Feide , Hou Qianqian , Li Tengzhou , Du Wenke , Zhang Yabo , Chang Shumin , Zhang Liwen , Zhang Yuntao
Published: January 2024

BACKGROUND
Rabies virus is a fatal zoonotic disease which the pathogenesis has not been fully elucidated, vaccination is the only effective method to protect against rabies virus infection. Most inactivated vaccines are produced using Vero cells (African green monkey kidney cells) for its large-scale productivity. However, there is a potential carcinogenic risk due to the non-human DNA contamination. Thus, replacing Vero cells with human diploid cells is a better solution. In this study, we invented a 2BS adapted rabies virus strain and analyzed its sequence, virulence and immunogenicity to prepare a new strain that may be used in the production of human diploid cell inactivated vaccine.
METHODS AND RESULTS
The human diploid adapted rabies virus strain 2aG4-B40 was established at the 40th generation by the combination of passage and pick spot in 2BS cells. The RNA sequence analysis showed that the mutations in 2BS adapted strains were not located on the key sites that affect the production of neutralizing antibodies and virulence compared to aG strain (GQ412744.1). The gradually increased virulence (remained above 7.0LogLD50/ml from the 40th to 55th generation) and antigen further indicated that these mutations may enhance the affinity of adapted strains to human diploid cells. Identification tests showed that the 2BS adaption virus strain was neutralized by anti-rabies serum with a neutralization index of 19952. PrEP and PEP vaccination and the NIH test further indicated that the vaccine prepared with the 2aG4-B40 strain had high levels of neutralizing antibody (2.24 to 46.67 IU/ml), immunogenicity (protection index 270) and potency (average 11.6 IU/ml).
CONCLUSIONS
In this study, 2BS adapted strain of 2aG4 rabies virus was obtained at the 40th generation. The results of sequencing analysis and titer determination of the adapted strains showed that, the mutations in the adaptive process are not located at key sequence regions of the virus, and these mutations may enhance the affinity of adapted strains to human diploid cells. Meanwhile, vaccines made from the adapted strain 2aG4-B40 had high potency and better immunogenicity, which could be an ideal candidate rabies virus strain for inactivated vaccines preparation.
Capturing the heterogeneity of the pancreatic ductal adenocarcinoma tumor microenvironment: novel triple co-culture spheroids for drug screening and angiogenic evaluation
Authors: Verloy Ruben , Privat-Maldonado Angela , Audenaerde Jonas Van , Rovers Sophie , Zaryouh Hannah , De Waele Jorrit , Deben Christophe , Smits Evelien , Bogaerts Annemie
Published: January 2024

Background Pancreatic ductal adenocarcinoma (PDAC) poses a significant health threat with poor response to current treatment options. The desmoplastic reaction, characteristic of PDAC, hinders therapeutic efficacy and emphasizes the need for novel in vitro models to study the complex tumor microenvironment and increase translatability. Three-dimensional in vitro co-culture models with clinically relevant numbers of cancer-associated fibroblasts and endothelial cells are still lacking and lead to failure of clinical trials and low improvement of patient survival.Methods MiaPaCa-2 and BxPC-3 cancer cell lines, RLT-PSC and hPSC21 pancreatic stellate cell lines and the endothelial cell line HMEC-1 were seeded in ultra-low-attachment round-bottomed plates to form triple co-culture spheroids. A growth assay including all cell lines was performed to evaluate if DMEM or MCDB131 is most ideal for spheroid formation and culturing. Multi-color flow cytometry was used to quantify cell populations after three days of spheroid formation to optimize the seeding ratios. Drug response profiles of mono-culture and triple co-culture spheroids were made using a cell viability assay. Finally, a tube formation assay with spheroid-conditioned medium was performed to showcase the potential of our model for angiogenic studies.Results We developed a panel of high-throughput triple co-culture spheroid models of pancreatic cancer cells, pancreatic stellate cells and endothelial cells. We were able to capture different facets of PDAC heterogeneity in scope of the tumor microenvironment using two different cancer and stellate cell lines, and one endothelial cell line. Importantly, drug responses varied between mono-culture and triple co-culture spheroids, underlining the impact of the tumor microenvironment, spatial arrangement, and spheroid density on therapeutic outcomes. Gemcitabine and paclitaxel treatments revealed different drug response profiles depending on the combination of BxPC-3 or MiaPaCa-2 with RLT-PSC or hPSC21 in a triple co-culture environment. A tube formation assay showcased the potential of our models to assess angiogenesis, providing a quantitative understanding of a treatment-induced response.Conclusions Our study brings sophisticated high-throughput in vitro models that are easy to reproduce and provide valuable insights into PDAC research to improve translatability and preclinical screening efficacy. In addition, our triple co-culture spheroids are cheap and include the heterogeneity of the PDAC tumor microenvironment.
Bilateral optic nerve infiltration and leukemic retinopathy as initial signs of leukemia relapse with central nervous system involvement in an adult: A case report
Authors: Wang Yisai , Zhu Ling , Wang Hongtao , Li Zhen , Bai Ruomeng , Wei Qinghua , Huang Lin , Xu Ying , Li Songguo , Chen Hui
Published: January 2024

Background:
We describe a case in which bilateral optic nerve infiltration and leukemic retinopathy were the initial signs of disease relapse in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+-ALL) with central nervous system (CNS) involvement.
Case presentation:
A 65-year-old Asian female with Ph+-ALL in complete remission presented at our institution with symptoms of visual disturbance, central scotoma and pain with eye movement in both eyes for a 1-month duration. Ophthalmic examination revealed remarkable optic disc swelling with multiple flame-shaped peripapillary hemorrhages, retinal venous dilation and retinal hemorrhages in both eyes. She was subsequently referred to the treating oncologist and diagnosed with Ph+-ALL relapse with multiple relapsed diseases involving the bone marrow and CNS. After intrathecal (IT) therapy, her visual acuity dramatically improved, and her leukemic infiltrates decreased.
Conclusions:
To the best of our knowledge, this is the first case report of ALL relapse with CNS involvement presenting as bilateral optic nerve infiltration and leukemic retinopathy in an adult. Hence, we highlight the priority and sensitivity of ophthalmic examinations, as they are noninvasive methods for detecting leukemia relapse.
Aplastic anemia triggered by the Bruton tyrosine kinase inhibitor acalabrutinib in two patients with mantle cell lymphoma – a case report
Authors: Nikkarinen Anna , Glimelius Ingrid
Published: January 2024

The use of Bruton's tyrosine kinase inhibitors (BTKi) is rapidly increasing for patients with mantle cell lymphoma (MCL). Side effects reported so far are usually manageable and self-determining after dose-reduction or termination of the drug. However, here we present a new aspect of BTKi’s that needs to be taken into consideration as we report two cases of life-threatening aplastic anemia upon treatment with the BTKi acalabrutinib for MCL. The two patients were treated with acalabrutinib as first line treatment, patient 1 for a classical MCL with moderate proliferation and patient 2 for an aggressive tumor with blastoid morphology, p53 overexpression and high proliferation rate. Both patients had excellent tumor responses but within a few months they presented with trombocytopenia that quickly led to a fulminant pancytopenia. Acalabrutinib treatment was stopped immediately but the pancytopenia did not resolve. Investigations led to the diagnosis of the autoimmune disease aplastic anemia in both cases. Patient 1 died of neutropenic infection shortly after the diagnosis. Patient 2 was treated successfully with immunosuppression and regained near to normal blood counts, but subsequently developed relapsed MCL. Autoimmune diseases in general are overrepresented in patients with lymphoma, and there are reports of other autoimmune anemias such as autoimmune hemolytic anemia being triggered by lymphoma treatment. Aplastic anemia however, has never previously been reported as a potential side effect of BTKi in MCL. There is a possibility that this condition is underrecognized and mistaken for progression of tumor infiltration in the bone marrow. Aplastic anemia should be taken into consideration when patients present with pancytopenia during treatment with BTKi.
PyLST: A Python-based application for retrieving Land Surface Temperature from Landsat 5, 7, 8, & 9
Authors: Parvar Zahra , Salmanmahiny Abdolrassoul
Published: January 2024

Land Surface Temperature (LST) can be used to understand the impacts of changes in Land Use and Land Cover (LULC) through remote sensing. This research introduces an open-access Python-based user interface for retrieving LST from Landsat images (Landsat 5, 7, 8 & 9) using multiple algorithms including Mono Window Algorithm (MWA), Radiative Transfer Equation (RTE) method, Single Channel Algorithm (SCA) and Split Window Algorithm (SWA). This software enables users to efficiently choose the most suitable algorithms by comparing different methods within their study area. A total of 24 Landsat images, comprising six images for each Landsat mission and encompassing various seasons, were employed to assess and compare the accuracy of the algorithms. All methods presented acceptable results, however, RTE provided slightly better results for Landsat 5 and Landsat 7 with a lower RMSE value. In Landsat 8 and 9, SWA had better results than the other algorithms (RMSE 2.1°C).
Comparison of the effectiveness of microneedling with topical insulin versus saline (as a placebo) in the treatment of striae Alba using Antera 3D camera. Controlled left-right comparative study
Authors: Abdallah Marwa , Ibrahim Samah , Ragab Aya , Elhawatky Ahmed
Published: January 2024

Background
Striae Alba is caused by overstretching of the skin's dermis with permanent structural alteration of collagen fibers and scaring of the dermis. Microneedling stimulates a cascade of growth factors by multiple cutaneous injuries, which stimulates the migration, and proliferation of fibroblasts with the synthesis of new collagen. Insulin is of interest in the field of wound repair and can help in restoring the integrity of damaged skin.
Objectives
Evaluation of the clinical response, efficacy, safety, and adverse effect of combined microneedling with topical insulin compared to microneedling alone (with saline as a placebo) in treating stria alba.
Subjects and methods:
In this controlled left/right comparative study, microneedling with saline (as a placebo) was done on the right side of the abdomen, while the left half of the microneedling was done using topical insulin. For each patient; we did four sessions with 1 month in-between. We evaluated the treatment outcome using photographic documentation and a 3D Antera camera and measured the decrease in the indentation index.
Results
A significant decrease was found in the stria-alba indentation index after treatment in both the insulin sides and placebo sides; the insulin side being superior. There was no statistical significant difference between them as regards the side effects like erythema and hyperpigmentation.
Conclusion
Microneedling with topical insulin is an effective and safe method for treating patients with striae alba.
Dapagliflozin did not increase in serum K in advanced CKD in spite of initial eGFR decline
Authors: Mitani Waka , Iwata Yukimasa , Kobayashi Midori , Notsu Shoki , Morimoto Madoka , Yamato Masafumi
Published: January 2024

Sodium–glucose cotransporter 2 inhibitors (SGLT2i) exhibit renoprotective effect in patients with chronic kidney disease (CKD) and do not increase serum K levels in the long term. However, it is unknown whether SGLT2i increase serum K levels in patients with advanced CKD in the short term. This study aimed to investigate the impact of SGLT2i on changes in serum K levels in patients with advanced CKD.
Data of 127 Japanese patients with CKD who were newly administered 10 mg dapagliflozin in our department between August 2021 and August 2022 were analyzed. Changes in serum K and fractional excretion of K (FEK) were analyzed using multiple regression analysis.
Of 127 patients, 41 were excluded.
The median age was 67 years, and 70.9% were male. Overall, 24 (27.9%) patients had diabetes mellitus. The median estimated glomerular filtration rate (eGFR), serum K levels, and FEK were 35.4 mL/min/1.73 m2, 4.2 mEq/L, and 11.8%, respectively, at the time of dapagliflozin administration. Although eGFR declined to 33.2 mL/min/1.73m2 from 35.4 mL/min/1.73m2 after dapagliflozin administration (p<0.001), serum K and FEK levels increase to 4.3 mEq/L and 14.7% after dapagliflozin administration and it was not statistically significant.
Dapagliflozin did not increase serum K levels in patients with advanced CKD.
Comparison of standard endovascular repair and chimney graft for juxtarenal abdominal aortic aneurysm
Authors: Wang Mingshan , Cai Huoying , Liu Zhen , Huang Lin , Liu Ruiming , Wang Siwen , Qin Yuansen , Cui Jin , Chang Guangqi , Yao Chen , Wang Shenming , Wang Jinsong , Zhou Yu , Hu Zuojun
Published: January 2024

Objective
This study compared the efficacy of standard grafting (S-EVAR) and chimney grafting (Ch-EVAR) for treating juxtarenal abdominal aortic aneurysms(JAAA).
Methods
Data of patients with JAAA, who underwent S-EVAR and Ch-EVAR from January 2015 to December 2021 were collected. Follow-up was performed by CTA and ultrasonography of the aorta were performed before discharge, at 6 and 12 months postoperatively, and annually thereafter. Main outcome measures: AAA-related mortality, type Ia endoleak and reoperation
Results
A total of 62 patients underwent S-EVAR and 23 underwent Ch-EVAR. The proportion of men who underwent S-EVAR (91.9%, 57/62) was higher than the proportion who underwent Ch-EVAR (69.6%, 16/23) (p = 0.023). The postoperative incidence rate of type Ia endoleak was lower in S-EVAR (9.7% vs 13%, p = 0.698). Times for. hospitalization, ICU monitoring, operation, and anesthesia, and perioperative bleeding were less in S-EVAR (12 vs 17 days, 0 vs 1 day, 122.5 vs 220 min, 177.5 vs 300 min, 50 vs 100 mL, p < 0.05). In S-EVAR, a suprarenal aortic angle was associated with type Ia endoleak (p = 0.016). Median follow-up duration was 48 months, (range, 0–94 months) in the S-EVAR group and 42 months (range, 0–90 months) in the Ch-EVAR group. 1-year survival rate were (91.9% vs 91.3%), 3-year survival rate (81.7% vs 78.7%), 5-year survival rate (62.2% vs 45.8%) were not statistically different. No significant differences were found in postoperative complications. The long-term patency rate of chimney stent was 100%.
Conclusions
The off-label use of S-EVAR for JAAA, with a straight and 8–10 mm aortic neck length, can be considered safe and effective. Ch-EVAR is more suitable for JAAA with excessive twisting of the neck (suprarenal aortic angle < 114°). In this study, long-term data of both technologies showed satisfactory results in preventing aneurysm rupture and the related mortality.
Effect Of Dexmedetomidine On Controlled Hypotension In Hypertensive Patients Undergoing Endoscopic Sinus Surgery
Authors: Ye Li-Sha , Wang YiXuan , Wang BenFu , Jin YueXi , Ye WenLian , Jiang Tian-Fang
Published: January 2024

Nasal endoscopic surgery is a high-resolution, fine-grained procedure. With the development of nasal endoscopic surgery, the demand for a clear surgical field of vision is gradually increasing. Controlled hypotension technology can effectively reduce intraoperative bleeding and provide a clear visual field for surgery. In hypertensive patients, we use dexmedetomidine as an adjuvant on the basis of traditional nitroglycerin controlled hypotension. The experimental results show that the use of dexmedetomidine can help control blood pressure faster to the target blood pressure, while also exhibiting more stable performance during resuscitation and extubation. Although in terms of heart rate
The effect of motor interventions on gross motor skills in children with autism: a systematic review and META analysis
Authors: CAO YUANG , FAN LIXIA , MAO XIAOJIN
Published: January 2024

OBJECTIVE
To systematically and quantitatively evaluate the effects of different forms of interventions on the development of gross motor skills in children with autism and to provide a reference for further enhancing the development of gross skills in children with autism.
METHODS
Randomised controlled trials (RCTs) on gross motor skill interventions for children with autism were collected according to the criteria developed by searching in China Knowledge Network (CNKI), Wanfang Digital Resources, Wipu database, and web of science database. The Chinese and English search terms included: (autism OR autism spectrum disorder) AND (motor skill OR fundamental motor skill OR fundamental movement skill) AND (pupil OR child). The retrieved literature was screened, data extracted, and the quality of the included literature was evaluated using Cochrane. Meta-analysis and sensitivity analysis, regression analysis, and publication bias were performed using Review Manager 5.4 and Stata 15.1 software.
Result
Meta-analysis results showed that targeted motor interventions significantly improved the development of gross motor skills in children with autism and were effective in improving the total TGMD scores of children with autism (SMD = 13.61, 95% CI [8.77,18.46]). There was a significant increase in displacement skills (SMD = 7.07, 95% CI [5.20,8.94]) and object control skills (SMD = 6.55, 95% CI [4.98,8.12]). In terms of displacement skills, a certain duration of motor intervention had a good effect on children with autism for fast running, side sliding, single-leg jumping, and straddle jumping, but not for front sliding and standing long jump. In terms of object control skills: the motor intervention significantly improved children with autism's ability to throw the ball underhand, kick the ball, and hit the stationary ball, but not overhand throwing and slapping the ball in place.
Conclusion
Targeted motor interventions have an important role in promoting gross skills in children with autism spectrum disorders. Further research should be conducted to validate this with larger sample sizes and high-quality RCTs.
A case of newly diagnosed acute myeloid leukemia with multiple myeloma: challenges in diagnosis and treatment
Authors: Li Liang , Liu Haiyun , Liu Tingting
Published: January 2024

Background: It is a rare coincidence that acute myeloid leukemia and multiple myeloma are diagnosed simultaneously in patients without a history of malignant diseases and special treatment. The pathogenesis, differential diagnosis, and treatment of these patients are still unclear, and currently they are mainly evaluated based on the specific situation of MICM classification.
Case report: An 81 year old male with a 2-year history of hypertension was admitted to the hospital for treatment due to recurrent chest tightness and pain for 3 years, which worsened for 1 day. During physical examination, there is obvious chest tightness when lying flat, with general limited mobility, anemic appearance, visible bleeding points on the skin and mucosa, no fever, no liver, spleen, or lymph node enlargement. Bone marrow morphology examination showed active bone marrow hyperplasia, with 28% of primitive cells and weakly positive peroxidase staining; The proportion of plasma cells significantly increased, accounting for 15%; The mature red blood cells are arranged in a prominent shape. At the same time, flow cytometry and bone marrow biopsy revealed two different abnormal cell populations, with 42% being primitive myeloid cells and 10% being abnormally proliferating plasma cells. Serum M protein was detected by serum electrophoresis and immunofixation electrophoresis, and specific reaction precipitation bands were observed with anti IgG and anti LAM. The diagnosis was acute myeloid leukemia with multiple myeloma, and there was no history of malignant disease or special treatment.
Treatment and outcome: The patient initially received BCL inhibitor Venetoclax and demethylated drug Azarcytidine for the treatment of acute myeloid leukemia. Subsequently, due to severe cardiac insufficiency caused by coronary atherosclerotic heart disease, the patient could not tolerate the follow-up treatment, and was automatically discharged to the local hospital for life support treatment.
Discussion: In the clinical process of diagnosing and treating hematological diseases, it is rare for these two different types of clonal malignant hematological diseases to occur simultaneously. Patient based prospective studies and case series are needed to guide diagnosis and treatment strategies.
Depressive symptoms prevalence and its associated factors among cross border migrants in Thailand, 2023: a cross-sectional mixed-method study
Authors: Sikhiwat Naruemon , Rajsiri Kullatida , Nunes Jordanna , Uansri Sonvanee , Panapong Nitjanan , Kunpeuk Watinee , Adhibai Rujira , Wongsuwanphon Saruttaya , Suphanchaimat Rapeepong
Published: January 2024

Background: Depression constitutes a substantial portion of global mental health concerns. Among migrant populations, access to mental healthcare is often hindered by various barriers, potentially leading to undiagnosed depressive symptoms. Thailand has hosted a large number of cross-border migrants from its neighboring countries, especially, Cambodia, Laos PDR and Myanmar (CLM), for years. However, little is known about the prevalence of depressive symptoms and its associated factors amongst migrants in Thailand, and this comes the objective of this study.
Methods: We conducted a cross-sectional mixed-method study to assess the prevalence of depressive symptoms and identify its associated factors. Quantitative data were collected through a paper-based questionnaire which comprised demographic characteristics and depressive symptoms screening questions by the Department of Mental Health, the Thai Ministry of Public Health. Multiple logistic regression analysis was used to determine the related factors of depressive symptoms. Qualitative data were gathered by in-depth interviews with civic group representatives and migrants. Content analysis with inductive coding was applied.
Results: A total of 431 participants were included in the analysis, with the majority being female (73.3%) and from Myanmar (97.9%). The prevalence of depressive symptoms was 11.8%, categorized as mild (9.7%), moderate (1.6%), and severe (0.5%) respectively. Factors associated with reduced likelihood of depressive symptoms included having public insurance, completing at least high school education, and being employed, while alcohol consumption increased the odds of depressive symptoms. Qualitative analysis highlighted the protective role of public insurance against depressive symptoms. Besides, from the interviews, some migrants consumed alcohol as a coping mechanism towards depressive symptoms.
Conclusion: This study reveals a noteworthy prevalence of depressive symptoms among cross-border migrants in Thailand. Significant factors included being insured by public insurance scheme, obtaining favorable education background and being employed. A better understanding of how these factors contribute to depressive symptoms is vital in designing comprehensive mental health policies to address the mental well-being of migrants. Further studies that reach out to all types of migrants and expand the scope of mental health beyond depressive symptoms are recommended.
Comparison of Different Screening Methods for Selection of Ascochyta Blight Disease on Chickpea (Cicer arietinum L.) Genotypes
Authors: Aydoğan Abdulkadir
Published: January 2024

Chickpea (Cicer arietinum L.) is the second most important and commonly grown edible food legume crop all over the world. However, chickpea cultivation and production are mainly affected by Ascochyta Blight (AB) disease that results in up to 100% loss in areas having high humidity and warm temperature conditions. Various screening methods are used in the selection of chickpea genotypes for resistance to AB disease. These methods are Natural Field Condition (NFC), Artificial Epidemic Field Condition (AEFC), Marker Assisted Selection (MAS), and Real-Time PCR (RT-PCR). The study was conducted between the 2014 to 2016 growing seasons with 88 chickpea test genotypes. The results of the screening were used to sort the genotypes into the three categories susceptible (S), moderately resistant (MR), and resistant (R). Using MAS screening, 13, 21, and 54 chickpea genotypes were identified as S, MR, and R, respectively. For RT-PCR screening, 39 was S, 31 was MR, and 18 genotypes were R. NFC screening revealed 7, 17, and 64 genotypes that were S, MR, and R while 74 and 6 genotypes were S and MR, 8 genotypes were R to AB disease in the AEFC method.
Epidemiologic relationship between alcohol flushing and smoking in the Korean population: the Korea National Health and Nutrition Examination Survey
Authors: Yook Hwa Jung , Lee Gyu-Na , Lee Ji Hyun , Han Kyungdo , Park Young Min
Published: January 2024

Although facial flushing after drinking alcohol (alcohol flushing response) is common in Asian populations, the epidemiological features in a large sample have been investigated in only a few studies. This study assessed the epidemiologic characteristics and risk factors of alcohol flushing in a Korean population. This study was based on data collected during the 2019 Korea National Health and Nutrition Examination Survey (KNHANES). A total of 5,572 Korean adults was included in the general population group, and the alcohol flushing group consisted of 2,257 participants. Smoking and physical activity were evaluated as possible risk factors for alcohol flushing. The overall prevalence of alcohol flushing was estimated at 40.56% of the general population (43.74% in males and 37.4% in females), and the prevalence was highest at 60–69 years of age and lowest in individuals older than 80 years. Occasional, frequent, and persistent alcohol flushing was reported by 11.9%, 3.7%. and 15.0% of current flushers, among whom persistent flushers consumed the least amount of alcohol. The risk of alcohol flushing increased with current smoking status (adjusted OR 1.525, 95% CI 1.2–1.938), and smoking history of 20–29 pack-years (PYs) showed the highest association (adjusted OR 1.725, 95% CI 1.266–2.349) with alcohol flushing after adjustment for confounders. In contrast, significant association was not found between physical activity and alcohol flushing. The results demonstrated that current smoking could increase the risk of alcohol flushing, and that current smokers with a history of smoking > 20 PYs had a higher risk of alcohol flushing than non-smokers or ex-smokers.
Basal cell carcinoma superficial type is a basal cell carcinoma in situ
Authors: Kaur Harsimran , Bentley Karen L. de Mesy , Rahman Minhaj , R.Cohen Philip , Smoller Bruce R.
Published: January 2024

Background:
Basal cell carcinoma (BCC) is the most common skin cancer with rising incidence. Skin cancers may present either as non-invasive or invasive malignancy. The terminology of carcinoma in situ is used when the tumor is either just limited to epidermis or not present as single cells or nests in the dermis. However, unlike the usual terminology, superficial BCC instead of BCC in situ is used for BCC that is limited to epidermis.
Purpose:
We aim to compare the histomorphology of superficial BCC to nodular and infiltrative BCCs using electron microscopy to identify the ultrastructural characteristics and validate the previously proposed terminology.
Methods
A total of three cases from three BCC types (superficial BCC, nodular BCC, and infiltrative BCC) diagnosed by dermatopathologists at our institute were selected for review. Paraffin block tissue from these cases was sent for electron microscopy studies.
Results
Electron microscopy demonstrates disruption of basal lamina in both nodular and infiltrative type of BCC, while it remains intact in BCC superficial type after extensive examination.
Conclusion
Our study demonstrates intact basal lamina in the BCC superficial type; therefore, like with other in situ skin cancers there is no invasion of the neoplasm into the dermis. Therefore, the older term superficial BCC should be appropriately replaced with the newer terminology BCC in situ.
Myoclonus improvement after seizures in progressive myoclonic epilepsy type 7: a case report
Authors: Guimarães Thiago Gonçalves , Nóbrega Paulo Ribeiro , Freua Fernando , Lima Pedro Lucas Grangeiro de Sá Barreto , Braga-Neto Pedro , Paiva Anderson Rodrigues Brandão , Kok Fernando
Published: January 2024

Background: Progressive Myoclonic Epilepsy (PME) is a group of rare diseases that are difficult to differentiate from one another based on phenotypical characteristics.
Case Report: We report a case of PME type 7 due to a pathogenic variant in KCNC1 with myoclonus improvement after epileptic seizures.
Discussion: Myoclonus improvement after seizures may be a clue to the diagnosis of Progressive Myoclonic Epilepsy type 7.
Identification of small molecule inhibitors against Lin28/let-7 to suppress tumor progression and its alleviation role in LIN28-dependent glucose metabolism
Authors: Raja Rachanaa , Sundarraj Rajamanikandan , Kandasamy Ruckmani
Published: January 2024

The reciprocal suppression of an RNA binding protein LIN28 (human abnormal cell lineage 28) and miRNA Let-7 (Lethal 7) is considered to have a prime role in hepatocellular carcinoma (HCC). Though targeting this inhibition interaction is effective for therapeutics, it causes other unfavorable effects on glucose metabolism and increased insulin resistance. Hence, this study aims to identify small molecules targeting Lin28/let-7 interaction along with additional potency to improve insulin sensitivity. Of 22,14,996 small molecules screened by high throughput virtual screening, 6 molecules, namely 41354, 1558, 12437, 23837, 15710, and 8319 were able to block the LIN28 interaction with let-7 and increase the insulin sensitivity via interacting with PPARγ (peroxisome proliferator-activated receptors γ). MM-GBSA (Molecular Mechanics-Generalized Born Surface Area) analysis is used to re-score the binding affinity of docked complexes. Upon further analysis, it is also seen that these molecules have superior ADME (Absorption, Distribution, Metabolism and Excretion) properties and form stable complexes with the targets for a significant period in a biologically simulated environment (Molecular Dynamics simulation) for 100 ns. From our results, we hypothesize that these identified 6 small molecules can be potential candidates for HCC treatment and the glucose metabolic disorder caused by the HCC treatment.
HDAC Inhibitor Regulates the Tumor Immune Microenvironment via Pyroptosis in Triple Negative Breast Cancer
Authors: YANG XUE , Cui Xiaoqing , Wang Ge , Zhou Mengying , Wu Yonglin , Du Yaying , Li Xingrui , Xu Tao
Published: January 2024

Objective
Pyroptosis, an inflammatory form of cell death, promotes the release of immunogenic substances and stimulates immune cell recruitment, a process which could turn cold tumours into hot ones. Thus, instigating pyroptosis in triple-negative breast cancer (TNBC) serves as a viable method for restoring anti-tumor immunity.
Methods
We analyzed the effects of Histone Deacetylase Inhibitors (HDACi) on TNBC cells using the CCK8 and colony formation assay. Apoptosis and lactate dehydrogenase (LDH) release assays were utilized to determine the form of cell death. The pyroptotic executor was validated by qRT-PCR and Western Blot. Transcriptome was analyzed to investigate pyroptosis-inducing mechanisms. A subcutaneously transplanted tumor model was generated in BALB/c mice to evaluate infiltration of immune cells.
Results
HDACi significantly diminished cell proliferation, and pyroptotic “balloon”-like cells became apparent. HDACi led to an intra and extracellular material exchange, signified by the release of LDH and the uptake of propidium iodide. Amongst the gasdermin family, TNBC cells expressed maximum quantities of GSDME, and expression of GSDMA, GSDMB and GSDME were augmented post HDACi treatment. Pyroptosis was instigated via the activation of the caspase 3-GSDME pathway with the potential mechanisms being cell cycle arrest and altered intracellular REDOX balance due to aberrant glutathione metabolism. In vivo experiments demonstrated that HDACi can activate pyroptosis, limit tumor growth, and escalate CD8 + lymphocyte and CD11b + cell infiltration along with an increased presence of granzyme B in tumors.
Conclusion
HDACi can instigate pyroptosis in TNBC, promoting infiltration of immune cells and consequently intensifying the efficacy of anticancer immunity.
GIS Based Artificial Neural Network(Ann) Method for Flood Susceptibility Mapping Case of Djelfa City (Algeria)
Authors: Ameur Harfouche , lynda Djerbal
Published: January 2024

Djelfa city situed in the center of Algeria,is particuulary prone to the risk of flooding due to its topography and location,especially considering the presence of unpredictable and forceful watercourses like Oued mellah and Oued boutrifis flowing through the urban area. Various methods exist for predicting and mapping flood susceptibilityand the latest approaches involve deep learning machine and artificial neural networks,which were employed in the current study.
Four geoenvironmentalflood conditioning factors were considered including elevation, slope,urban density and distance to streams. Recent artificial neural network(ANN)model has been used to obtain an optimal output with minimized cross entropy error and better assess flood susceptibility in Djelfa City.The weights for each factor were determined using the backpropagation training method.Subsequently,flood susceptibility indices were calculated using the trained backpropagation weights and susceptibility maps were created based on geographic information system (GIS) data.The results of the flood susceptibility maps were then compared to flood location data to validate the model.The good convergence of the resultsclearly demonstrates that artificial neural network is an effective tool to analyzing flood susceptibility.