bluuebunny/crossref_metadata_2025 huggingface dataset:
α-Globin Messenger Ribonucleic Acid as a Molecular Marker for Determining the Age of Human Blood Spots in Different Temperatures
Authors:   Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Cairo, Egypt., Mostafa Eid Heba Abdullah , Ibrahim Elbarrany Usama Mohammed ,   Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Cairo, Egypt., Ghaleb Sherien S. ,   Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Cairo, Egypt., Mohamed Mohamed Adly ,   Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Cairo, Egypt., Sabry Abdelfattah Dina ,   Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt., Aboubakr Heba Mohamed ,   Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Published: September 2022

Background: Analyzing recovered evidence, such as blood which is one of the most encountered types of biological evidence, can provide information to establish the definite time when a crime was committed. This study aims to investigate the timeand temperature-related effects on human bloodstain’s α-globin messenger RNA expression and to estimate the bloodstain’s age using α-globin mRNA. Methods: A total of 22 blood samples were collected from healthy middle-aged volunteers (12 women and 10 men). After preparation, the samples were exposed to temperatures of 4°C, 24°C, and 40°C. Next, the mRNA expression of the α-globin gene was quantified by real-time RT-PCR at different time intervals of 0, 30, 90, and 150 days. Results: The α-globin gene expression showed the highest mean values by 0 day and at 4°C and the lowest mean values by 150 days and at 40°C. Samples from male participants showed higher mean values of α-globin gene expression compared to their female counterparts. A significant negative correlation was detected between α-globin gene expression and time interval. Meanwhile, a regression equation was formulated to estimate the time interval using the α-globin gene concentration. Conclusion: α-Globin mRNA could be a useful marker to estimate the age of human blood spots.
Strategic planning of balanced development of the Vasyliv territorial community
Authors: Babii Oleg ,   Odessa National Economic University, Kovalov Anatoly ,   Odessa National Economic University, Kotova Inna ,   Odessa National Economic University, Korolova Tetiana ,   Odessa National Economic University, Pavlova Tetiana ,   Odessa National Economic University, Tarasova Krystyna ,   Odessa National Economic University, Shevchenko-Perepolkina Radyslava ,   Odessa National Economic University, Nosachenko Oleksandr ,   Odessa National Economic University
Published: September 2022

The monograph contains conceptual provisions for ensuring local economic development of territories, creating conditions for full use of labor potential and social involvement in order to improve the lives of community residents, based on the principles of sustainable development. Realization of the main goal of the development of the community consists in the correct choice of the main tasks and the arrangement of the main priorities of the economic and social development of the territory of the community and its potential opportunities. The peculiarities and conditions of application of certain tools for ensuring the balanced development of the Vasyliv territorial community of the Bolgrad district of the Odesa region are disclosed. The Development Strategy of Vasylivska OTG is developed. It is a document about which changes can and should be made that arise with the development of society and changes in the economic and political climate in the country.
Marketing and logistics aspects of the activities of export-oriented enterprises
Authors: Tarasova Krystyna ,   Odessa National Economic University, Smyrnova Nataliia , Obniavko Oleksandr ,   Odessa National Economic University, Kukharska Nataliia ,   Odessa National Economic University, Andryeyeva Natalya ,   Odessa National Economic University, Postan Mykhailo , Saiensus Mariia ,   Odessa National Economic University, Rulinska Olha ,   Odessa National Economic University, Zharska Iryna ,   Odessa National Economic University, Sotnikov Yuri ,   Odessa National Economic University, Shkurupska Iryna ,   Odessa National Economic University, Polyanskaya Olga ,   Odessa National Economic University, Salo Yana ,   Odessa National Economic University, Berber Anastasiya ,   Odessa National Economic University, Bespalov Volodymyr ,   Odessa National Economic University, Novak Hanna ,   Odessa National Economic University, Gubernik Arkady ,   Odessa National Economic University, Sheremeta Oleksandra ,   Odessa National Economic University, Butenko Anna ,   Odessa National Economic University
Published: September 2022

The monograph presents the results of a comprehensive study of the theoretical foundations of marketing and logistics activities of export-oriented enterprises. The methodical foundations and practice of modern marketing activities of economic entities of Ukraine and the world in the conditions of the movement towards the digital economy are analyzed and highlighted. The monograph is intended for scientists, practitioners, managers of enterprises, regional marketing managers, logisticians, graduate students and students of all specialties, as well as for all interested persons.
PENGARUH UKURAN PERUSAHAAN, SISTEM PENGENDALIAN INTERNAL, DAN LEVERAGE TERHADAP AUDIT DELAY (Studi pada Perusahaan Jasa Transportasi yang Terdaftar di Bursa Efek Indonesia Tahun 2014 - 2017)
Authors: Haryani Titik , Rispantyo Rispantyo , Puji Astuti Dewi Saptantinah
Published: September 2022

Timeliness of accounting information publication can be affected by short and long audit delay. Some of the factors that may affect the length of audit delay are company size, internal control system and leverage. This research is testing the significance of the influence of the size of the company, internal control systems, and leverage against the audit delay. This research was conducted on the transportation services company listed on the Indonesia stock exchange during the years 2014 - 2017. With a purposive sampling method sampling and retrieved samples of as many as 28 companies from 45 companies. This research is using double linear regression technique. The results showed that company size variable has no significant effect on audit delay variable, internal control system variable significant negatif effect on audit delay variable, and leverage variable has no significant effect on audit delay variable.
ANALISIS PERBEDAAN PROFITABILITAS, TOTAL ASSET TURN OVER, KEBIJAKAN UTANG DAN KEBIJAKAN PEMBAGIAN DIVIDEN PADA PERUSAHAAN ROKOK, PERUSAHAAN KONTRUKSI DAN BANGUNAN SERTA PERUSAHAAN SEMEN YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Firdaus Rizqi Romadhani Ati , Widarno Bambang , Harimurti Fadjar
Published: September 2022

The purpose of this study was to analyze the effect of profitability, total asset turnover and debt policy on dividend policy and to analyze differences in dividend policy in cigarette companies, construction and building companies and cement companies listed on the Indonesia Stock Exchange. This type of research is a case study. A sample of 18 cigarette companies, cement and construction and building companies are listed on the Indonesia Stock Exchange 2013 – 2016. Data collection techniques use documentation. Data analysis techniques use Desciptive test and Post Hoc test.. The results of shows that there is a difference ROA, TATO, debt policy and dividend policy in cigarette companies, construction and building companies and cement companies listed on the Indonesia Stock Exchange.
PENGARUH TRANSPARANSI, AKUNTABILITAS DAN PARTISIPASI MASYARAKAT TERHADAP PENGELOLAAN ALOKASI DANA DESA DI DESA SIDOHARJO KECAMATAN SIDOHARJO KABUPATEN SRAGEN
Authors: Firdaus Anita , Suharno Suharno , Sunarti Sunarti
Published: September 2022

The study aims to examine the influence of transparency, accountability and society participation management of village fund allocation. The study used survey method with questionnairs as its instrument. The population of this study are the rural society and officials village Sidoharjo sub-district Sidoharjo in the district of Sragen. Based on purposive sampling , the number of samples obtained is 80 people. The type in this study is a quantitative study with a view to found the truth contained in this study, which is using multiple linear regression test and tested the validity and reliability the quality of the questionnairs with SPSS 21sofware application. The result of this study found that transparency, accountability and society participation have a significant positive effect management of village fund allocation. This study is expected to provide input for the rural goverment to synergize to improve transparency, accountability and society participation in management og village fund allocation.
Investigation of the working capacity of the operating body suspension functional-transporting machine
Authors: Babii Andrii , Aulin Victor , Babii Mariia , Levytskyi Bohdan
Published: September 2022

The investigation concerning the identification of the effectiveness of reducing the oscillations of the sprayer boom developed by independent pendulum suspension is carried out in this paper. In order to achieve this goal, the field microrelief, which creates kinematic perturbation of the rod oscillations is simulated. Dynamic model of rod mass oscillations on this suspension is also constructed, numerical solutions for a given sprayer operation mode are obtained, and numerical results are analyzed.
Interpretation of Acousting Sounding Records with Meterological Parameters and Ventilation Coefficient Over Delhi
Authors: Singh P. , Soni K. , S. Nair A. , Kumar N. , Sharma R.
Published: September 2022

Atmospheric Boundary Layer (ABL) height is an important parameter in defining the Ventilation Coefficient (VC) of any area. In this work, SODAR (Sound Detection and Ranging) observed data of different echograms for the year 2020 has been used for structure identification. The interpretation of ecograms is often not straight-forward. In this paper, an interpretation of different echograms along with meteorological parameters over Delhi is described. The ecogram structures were interpreted along with VC analysis. It is observed from the structures that during foggy days, VC values vary from day to day in the winter, with daily maximum values occurring between 13:00 and 15:00 h. The daytime values varied significantly from sunrise to sunset, while the night-time values remained relatively stable (200 m2/s). However, due to fog diurnal variation from 16:00 h to 11:00 h, that is from evening to all night and then the next morning until 12:00 h, the atmospheric condition remained stable. At maximal wind speeds, a maximum VC of 1600 m2/s (at 12:00 h) was observed during extended fumigation. With minimal wind speeds and ABL height, a minimum VC of 100 m2/s (at 20:00 h) was observed. However, both VCs were smaller than the optimal VC for 6000 m2/s safe dispersion.
Impacto social de la cuarta revolución industrial y la responsabilidad social empresarial como respuesta
Authors: David López Guerdis Paola
Published: September 2022

La investigación se enfocó en analizar el impacto social de la cuarta revolución industrial, considerando a la RSE como respuesta a sus desafíos. Se identificó el impacto que tiene sobre la sociedad, la empresa 4.0 y la aplicación de los principios de la RSE para responder a los retos que imponen. Se siguió el proceso de consulta en diferentes medios electrónicos y físicos; se utilizaron bases de datos como: SciELO y Redyalic; así como indagación en buscadores. La investigación fue de tipo documental bibliográfica, al aplicar los criterios de inclusión y exclusión, quedaron 30 artículos. El resultado indicó, que la RSE se constituye en un marco idóneo para orientar a la alta gerencia en la toma de decisiones de las empresas durante la cuarta revolución industrial. Concluyéndose, que es posible reducir el impacto social de las Industria 4.0, con la implementación de una gerencia basada en los principios de la RSE
Konsep Teologi Dalam Cerita Srinandi
Authors: Putri Ni Kadek Ayu Kristini
Published: September 2022

Sastra yang dibuat pada jaman dahulu mempunyai beragam tema tentang kehidupan manusia. Kisah-kisah kehidupan yang tak luput dari tulisan baik berupa prosa, lontar maupun tutur yang berupa lontar sangat identic dengan kehidupan sekarang. Kisah Srinandi yang berupa sastra tutur tersebut tidak jauh dari kehidupan sekarang bak layaknya sinetron masa kini yang berbeda jaman. Untuk menghasilkan data yang valid dan reliable, maka penelitian ini menggunakan metode penelitian kualitatif. Untuk menghasilkan data yang bersifat logis, artikel ini melakukan beberapa tahapan pemilahan data berupa : 1). Mereduksi data, 2). Mendisplay data, 3). Memverifikasi data dan, 4). Menginterpretasi data artikel. Refrensi terkait sangat menunjang validitas suatu karya ilmiah, oleh karena itu digunakan juga teknik kepustakaan melalui penjajakan literature di google scholar. Kisah dalam lontar Srinandi tersebut yang mengisahkan kisah pernikahan yang berujung dengan pembunuhan dengan adanya unsur orang ketiga sangat kental dengan adanya campur tangan tuhan itu sendiri. Bhaktinya sang Srinandi sendiri yang membuahkan hasil berupa sorga, karena perjalanan hidup Srinandi yang sangat taat dan bhakti semasa hidupnya.
POLA INTERAKSI KEBERAGAMAAN MASYARAKAT MULTIKULTUR DI DESA PENGASTULAN KECAMATAN SERIRIT (Perspektif Pendidikan Sosiokultural)
Authors: Gata I Wayan
Published: September 2022

Desa Pengastulan sejak dahulu sudah terkenal dengan penduduknya terdapat banyak umat Muslimnya atau ada agama Islam, tetapi desa tersebut secara umum terlihat tentram dan damai tidak terjadi pergesekan yang begitu berarti. Sedangkan secara asal usul penduduknya juga beranekaragam seperti terdapat suku Bali, suku Jawa, suku Madura dan suku Bugis sehingga dari keragaman tersebut tentunya sangat sulit untuk menyamakan kebiasaan dan tata cara bermasyarakat. Untuk menghasilkan data yang valid dan reliable, maka penelitian ini menggunakan metode penelitian kualitatif. Untuk menghasilkan data yang bersifat logis, artikel ini melakukan beberapa tahapan pemilahan data berupa : 1). Mereduksi data, 2). Mendisplay data, 3). Memverifikasi data dan, 4). Menginterpretasi data artikel. Refrensi terkait sangat menunjang validitas suatu karya ilmiah, oleh karena itu digunakan juga teknik kepustakaan melalui penjajakan literature di google scholar. Hasil dari penelitian ini yakni: Interkasi Di Masyarakat Desa Pengastulan,  Upaya-upaya dalam melakukan Interaksi Di Desa Pengastulan, tidak hanya upaya, Kendala-Kendala dalam Interaksi juga terdapat didalamnya. Beragam kendala yang terdapat dalam interaksi sebagai berikut seperti:kurangnya tingkat pendidikan, klaster ekonomi yang beragam dan penyesuaian diri dengan lingkungan.
PENGARUH MODEL PEMBELAJARAN BERBASIS MASALAH DIVARIASI DENGAN PENERAPAN ICE BREAKER UNTUK MENINGKATKAN HASIL BELAJAR SISWA KELAS XI IPA SMA NEGERI 3 TALIABU UTARA
Authors: Saraha Abdul Rasid , Abu St. Hayatun Nur , Nufus Hayatun
Published: September 2022

This study aims to determine the effect of the variation problem based learning model with the implementation of Ice Breaker towards student’s learning outcomes of class 11 IPA at SMA Negeri 3 Taliabu Utara about chemical equilibrium. The type of research used in this study is experimental research with a one group pretest posttest design. The samples of this study were 20 students of class 11 IPA at SMA Negeri 3 North Taliabu which were selected by using saturated sampling technique. The instruments used in this Study were in the form of essay questions consisting of 8 items to measure students’ learning outcomes and observation sheet to measure of the effective and psychomotor domains. The data analysis technique used in this study was inferential statistical analysis using SPSS 21.0. The results of analysis showed that there effect of variation problem based learning model with the implementation of Ice Breaker towards students’ learning outcomes of class 11 IPA at SMA Negeri 3 North Taliabu about chemical equilibrium, with the results of hypothesis test obtained:tcount<ttable or -8.205<1.729, meanwhile the results of affective domain anlysis reached 53 and psychomotor domain reached 53.
LITERASI ASESMEN MAHASISWA CALON GURU PADA FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS KHAIRUN TERNATE
Authors: Jusuf Ridwan , Hadi Dharmawaty , Papuangan Nurmaya
Published: September 2022

This study aims to determine the literacy level of the assessment of prospective teachers at the Faculty of Teacher Training and Education Unkhair. Respondents in this study were 3rd, 5th, and 7th semester students spread over 10 FKIP study programs, respondents were asked to fill out an assessment literacy test instrument which was developed based on the Assessment Literacy Standard. There are seven assessment literacy standards that can be used to measure the assessment literacy of prospective teachers, including: choosing assessment methods, developing assessment methods, managing and interpreting assessment results, using assessment results, developing assessment procedures, communicating assessment results and recognizing unethical assessment methods, illegal, and inappropriate. The instrument was given to respondents through the googleform application. The collected data was then analyzed with descriptive statistics. The results of this research analysis can reveal the level of literacy skills in the assessment of prospective teachers in 10 study programs as follows: Indonesian Language and Literature Education 73% high category, English Language Education 72% high category, Pancasila and Citizenship education 74% high category, Geography Education 75% category High category, Chemistry Education 77% high category, Physics Education 78% high category, Biology Education 78% high category, Early Childhood Education 76% high category and Elementary School Teacher Education 78% high category. Based on the results of the data analysis, it can be concluded that the average assessment literacy ability for prospective teachers in FKIP is in the high category, this happens because the content of the learning evaluation courses in each FKIP study program has given a good understanding to prospective teacher students as a provision for later becoming teachers who are professional in assessing and evaluating students in schools.
The Financial Data Services Domain: From Taxonomies to Ontologies
Authors: Russo Dario , Mura Gianluca
Published: September 2022

There are many different types of instruments and hundreds of different markets for investment, leading to an extremely large and hard-to-define universe of financial data. The related commercial offer is extremely heterogeneous and complex. In this scenario, it is difficult to source the most appropriate financial services providers. In the past, eProcurement was mainly focused on the use of ERP management tools to record and examine previous buying decisions and expenditure data. In recent years, machine learning and artificial intelligence have been applied to procurement workflows, introducing computation of external or third party unstructured data to achieve a higher level of market knowledge and decision automation. In order to exploit the possibilities provided by these new technologies to the full extent possible, theoretical models for understanding large amounts of unstructured data are essential. In this research-in-progress paper we propose a taxonomy of financial data services and depict the related prototype ontological model, providing a possible conceptualisation and specification of the domain of interest potentially useful for the development of applications based on semantic technologies.
Holistic leader: discussing the emerging challenges
Authors: A. Stavrou Lina , Galanou Aikaterini
Published: September 2022

In today's environment the leader is already faced with changes in the status quo of the field of work. Changes such as automation and digitization of work, changing forms of employment and the constant demand for further specialization make up an explosive context that could not easily be considered productive and psychologically likable for humans. There has been a great demographic shift, therefore different generations of employees need to be led properly within the organization. On the threshold of the 4.0 industrial revolution, leaders need to balance variables such as technological advances and the generational differences and/or clashes. To properly lead the organization, leaders must have abilities and skills that fall within all four capitals, economic, human, social and positive psychological capital. The ever-evolving theory of leadership highlights the characteristics that leaders must have for the organization to prosper and subordinates/followers as well. The paper discusses the leadership theory and the emergence of e-leadership. The new mentality and the differences within different generations are analyzed as well. The paper proposes the concept of the ‘holistic’ leader and discusses the gap regarding the leadership theories and the need for the higher education programs to be modified for the new leaders to be trained more effectively.
Interactive Effect of Export Strategic Orientations on Export Market Learning Ambidexterity: A Study of Turkish Export SMEs
Authors: Unal Nesibe Nur
Published: September 2022

The interactive effect of export strategic orientations on export market learning ambidexterity has been studied in this paper. Export market orientation and export entrepreneurial orientation, as strategic orientations, have a complement feature among them, while ambidexterity itself is a complement form of exploration and exploitation. In this study, the relationship between these two complement effects was examined by using 291 export SMEs located in Turkey which is an emerging economy. According to the results, a great impact from interactive effect of strategic orientations to ambidexterity is examined. Also, in line with the previous researches, the results confirmed that export strategic orientations individually have impact on exploration and exploitation. The findings help provide a more complete understanding of how export strategic orientations might be related to export market learning dimensions. It is revealed that both types of orientations provide different managerial efforts individually and interactively to develop and foster exploration, exploitation and ambidexterity in export markets.
Chronically stressed benthic macroinvertebrate communities exhibit limited effects on ecosystem function in a microtidal estuary
Authors: Cronin-O’Reilly S , Wells NS , McCallum R , Hallett CS , Tweedley JR , Valesini FJ , Eyre BD
Published: September 2022

Anthropogenically driven alterations to coastal sediments and their benthic macroinvertebrate communities impair ecosystem function. However, this paradigm is yet to be tested in ecosystems that typically harbour underdeveloped communities lacking larger bioturbating species. Here, we investigated the effects of sediment condition and macroinvertebrate communities on benthic metabolism, nutrient exchange and denitrification (N2 production), and assessed the relative importance of taxon richness, abundance, biomass and community bioturbation potential in influencing these processes in 2 regions of the highly modified, microtidal Peel-Harvey Estuary in temperate Western Australia. Sediment condition influenced benthic metabolism more than the macroinvertebrate community, whereas the reverse was true for nutrient exchange. Denitrification was driven by sediment condition and the community in the upper and lower estuary, respectively, highlighting the change in controls of this nitrogen-removal process within estuaries. Overall, benthic macroinvertebrates had little to no effect on many ecosystem processes, exhibiting the limited functional role played by these chronically stressed biota in this estuary. There was also no interaction between sediment condition and the community, suggesting a functional decoupling between these 2 ecosystem components. Where significant macroinvertebrate effects were detected, community biomass was the most frequently selected predictor, demonstrating its fundamental role in ecosystem function. This study reveals pressing implications of what might be expected when benthic environments become particularly degraded and the highly limited potential of the resultant benthic macroinvertebrate communities to provide key ecosystem services such as nutrient processing.
Kadınlarda Algılanan Ayrımcılık, Göreli Yoksunluk ve Kolektif Eylem Arasındaki İlişkilerin İncelenmesi
Authors: Tayınmak İlknur , Türkeli Aras
Published: September 2022

Dünyanın birçok bölgesinde kadınlar toplumsal cinsiyet rolleri ve algıları temelinde ayrımcılığa, şiddete ve fırsat eşitsizliğine maruz kalmaktadır. Kadınların maruz kaldıkları bu olumsuz tutum, davranışlar ve bunlara bağlı algılar, onların kolektif eylemlilikleri ile ilişkilidir. Bu bağlamda, mevcut araştırmada kadınların cinsiyet temelli ayrımcılık algısı, göreli yoksunluk algısı ve kadın hakları çerçevesindeki kolektif eylemleri arasındaki ilişkilerin ele alınması ve bu ilişkilerde siyasi görüşün rolünün incelenmesi amaçlanmıştır. Mevcut çalışmanın örneklemini Türkiye’nin çeşitli bölgelerinden 328 gönüllü kadın katılımcı oluşturmuştur. Katılımcılara Göreli Yoksunluk Ölçeği, Ayrımcılık Algısı, Siyasi Görüş, Kolektif Eylem ve Kolektif Eylem Niyeti’ne ilişkin ölçeklerin yer aldığı bir anket formu uygulanmıştır. Yürütülen analizler sonucunda kadınların cinsiyetlerine ilişkin ayrımcılık algılarının göreli yoksunluk algılarını, göreli yoksunluk algılarının ise ilgili konuda faaliyet gösteren bir sivil toplum kuruluşuna üyelik niyetlerini pozitif şekilde yordadığı; bu ilişkilerde siyasi görüşün düzenleyici rol oynadığı bulgulanmıştır.
A method for generating dynamic compression shear coupled stress loading on living cells
Authors: Xu Dasen , Zhang Nu , Wang Sijie , Zhang Pan , Li Yulong , Yang Hui
Published: September 2022

Changes in the mechanical properties of single cells are related to the physiological state and fate of cells. The construction of cell constitutive equations is essential for understanding the material characteristics of single cells. With the help of atomic force microscopy, bio-image processing algorithms, and other technologies, research investigating the mechanical properties of cells during static/quasi-static processes has developed rapidly. A series of equivalent models, such as viscoelastic models, have been proposed to describe the constitutive behaviors of cells. The stress-strain relations under dynamic processes are essential to completing the constitutive equations of living cells. To explore the dynamic mechanical properties of cells, we propose a novel method to generate a controllable dynamical compression shear coupling stress on living cells. A CFD model was established to visualize this method and display the theories, as well as assess the scope of the application. As the requirements or limitations are met, researchers can adjust the details of this model according to their lab environment or experimental demands. This micro-flow channel-based method is a new tool for approaching the dynamic mechanical properties of cells.
Six-component synthesis and biological activity of novel spiropyridoindolepyrrolidine derivatives: A combined experimental and theoretical investigation
Authors: Hossaini Zinatossadat , Mohammadi Marziyeh , Sheikholeslami-Farahani Fatemeh
Published: September 2022

Petasites hybridusrhizome water extract was used as green media for the preparation of Ag/Fe3O4/CdO@multi-walled carbon nanotubes magnetic nanocomposites (Ag/Fe3O4/CdO@MWCNTs MNCs), and its activity was evaluated by using in the one-pot multicomponent reaction of isatins, acetyl chloride, secondary amines, vinilidene Meldrum’s acid, primary amines, and malononitrile in an aqueous medium at room temperature for the generation of spiropyridoindolepyrrolidine as new derivatives with tremendous output. In addition, organic pollutant reduction of 4-nitrophenol (4-NP) was carried out by generated Ag/Fe3O4/CdO@MWCNTs in water at room temperature. The results displayed that Ag/Fe3O4/CdO@MWCNTs were reduced as pollutants of organic compounds in a short time. The synthesized spiropyridoindolepyrrolidine has an NH2functional group that has acidic hydrogen and shows high antioxidant ability. Also, the spiropyridoindolepyrrolidine exhibited antimicrobial ability, and the method that is used for this purpose is the disk diffusion method, and two kinds of bacteria, Gram-positive and Gram-negative, were employed for this analysis. Also, to better understand the reaction mechanism density, functional theory-based quantum chemical methods have been applied. For the generation of spiropyridoindolepyrrolidine, the used process has many properties such as reactions with short time, product with good yields, and simple extraction of catalyst from the mixture of reaction.
Determination of phage susceptibility as a clinical diagnostic tool: A routine perspective
Authors: Daubie Valéry , Chalhoub Houssein , Blasdel Bob , Dahma Hafid , Merabishvili Maya , Glonti Tea , De Vos Nathalie , Quintens Johan , Pirnay Jean-Paul , Hallin Marie , Vandenberg Olivier
Published: September 2022

As the global burden of disease caused by multidrug resistant bacteria is a major source of concern, credible clinical alternatives to antibiotic therapy, such as personalized phage therapy, are actively explored. Although phage therapy has been used for more than a century, the issue of an easy to implement diagnostic tool for determining phage susceptibility that meets current routine clinical needs is still open. In this Review, we summarize the existing methods used for determining phage activity on bacteria, including the three reference methods: the spot test, the double agar overlay plaque assay, and the Appelmans method. The first two methods rely on the principle of challenging the overnight growth of a lawn of bacteria in an agar matrix to a known relative phage to bacteria concentration and represent good screening tools to determine if the tested phage can be used for a “passive” and or “active” treatment. Beside these methods, several techniques, based on “real-time” growth kinetics assays (GKA) have been developed or are under development. They all monitor the growth of clinical isolates in the presence of phages, but use various detection methods, from classical optical density to more sophisticated techniques such as computer-assisted imagery, flow-cytometry, quantitative real-time polymerase chain reaction (qPCR) or metabolic indicators. Practical considerations as well as information provided about phage activity are reviewed for each technique. Finally, we also discuss the analytical and interpretative requirements for the implementation of a phage susceptibility testing tool in routine clinical microbiology.
Procalcitonin-guided antibiotic therapy for pediatrics with infective disease: A updated meta-analyses and trial sequential analysis
Authors: Li Peng , Liu JiaLe , Liu Junjun
Published: September 2022

Objective

We aimed to evaluate the effect of procalcitonin (PCT) guided therapy on antibiotic exposure in pediatric patients with infectious disease.

Methods

We performed an updated systematic review and meta-analysis of randomized controlled trials (RCTs) identified in systematic searches of MEDLINE, Embase, the Cochrane Database, Google Scholar, and SinoMed (through July 2021). The primary outcome was the length of the antibiotic therapy. Required information size (RIS) was calculated using trial sequential analysis (TSA).

Results

Four RCTs with 1,313 patients with infectious disease were included. Overall, after a mean 22-day follow-up, PCT-guided antibiotic therapy was associated with a significantly shorter length of antibiotic therapy compared with the control group (WMD, −2.22 days; 95% CI, −3.41 to −1.03; P <0.001) and a decreased rate of antibiotic adverse events (RR, 0.25; 95% CI, 0.11–0.58; P <0.001). However, the length of hospital stay (WMD, −0.39 days; 95% CI, −0.84 to 0.07; P = 0.094), rates of antibiotic prescription (RR, 1.10; 95% CI, 0.97–1.25; P = 0.122), hospital readmission (RR, 1.03; 95% CI, 0.92–1.16; P = 0.613) and mortality (RR, 0.73; 95% CI, 0.17–3.19; P = 0.674) were comparable between the PCT-guided antibiotic and control groups. TSA showed that the RIS was 2,340, indicating a statistically significantly shorter length of antibiotic therapy between PCT-guided antibiotic and control groups (P <0.05).

Conclusions

PCT-guided management seems to be able to decrease antibiotic exposure in patients with infectious disease. However, much larger prospective clinical studies are warranted to confirm these findings.
Contact-induced grammar formation: A model from a study on Hiberno-English
Authors: Shimada Tamami
Published: September 2022

This article examines how certain characteristic grammatical forms in Hiberno-English (HE) are the result of a dynamic process of language formation guided by language contact. A first language contact between Irish and English gives rise to the grammar formation of HE, and a second contact between HE and other varieties of English, presumably over the past 50 years or so, has pruned HE to fit the speakers' awareness toward the standard norm. Examinations of the expressions of tense/aspect and information structure in HE lead to suggestion of grammatical oppositions being inherited from Irish and the resilience of this inheritance in present-day HE. Taking three salient characteristics of HE, thebe afterperfect, thedo behabitual, and the 'tis….. construction as windows to its underlying properties, the article surveys earlier forms in the rise of HE and describes some facets of contemporary HE. One of the central issues in the examination is Irish language traits and their realization in HE morphosyntax. The article concludes by proposing an integrated perspective across the characteristics and a model to capture the grammar formation of HE, which can be applied to find similarities and contrasts with other language contact phenomena.
The safety of pericardiocentesis in patients under antithrombotic therapy: A single-center experience
Authors: Zhu Yuansong , Zhang Chengxiang , Xie Yuqiao , Sasmita Bryan Richard , Xiang Zhenxian , Jiang Yi , Gong Ming , Wang Yaxin , Chen Siyu , Luo Suxin , Huang Bi
Published: September 2022

Objective

This study aimed to analyze the characteristics of patients with pericardial effusion requiring pericardiocentesis and to evaluate the safety of pericardiocentesis without discontinuation of anticoagulant or antiplatelet drugs.

Methods

We performed a retrospective study of patients undergoing pericardiocentesis in our hospital between 2012 and 2022. Patients were categorized into the Antithrombotic Group if they had used any antiplatelet or anticoagulant drugs on the day of pericardiocentesis; otherwise they were categorized into the Non-antithrombotic Group. All procedures were performed by experienced cardiologists with echocardiographic guidance. Bleeding events were defined using the National Institutes of Health scale of adverse events.

Results

A total of 501 consecutive patients were identified and 70 cases were under antithrombotic drugs (Antithrombotic Group). Patients in Antithrombotic Group were older, had more comorbidities, presented with lower platelet counts and prolonged activated partial thromboplastin time (all p < 0.05). Malignancy was the most common etiology for pericardial effusion in both groups (28.6% in Antithrombotic Group and 54.7% in Non-antithrombotic Group) and tuberculosis was the second etiology in the Non-antithrombotic Group (21.9%), while procedure-related effusion (17.1%) accounted for the second cause in the Antithrombotic Group. Two patients in the Antithrombotic Group had mild oozing at the puncture site that resolved without interventions (2.9 vs. 0%, p = 0.019), and no bleeding events higher than Grade 1 occurred in either group.

Conclusion

Although antiplatelet or anticoagulant drugs may put patients undergoing pericardiocentesis at theoretically higher risk of bleeding, our study demonstrated that they are not associated with increased major bleeding complications.
Global pattern of cardiovascular disease management in patients with cancer and impact of COVID-19 on drug selection: IRAQ—IC-OS survey-based study
Authors: Farhan Hasan Ali , Yaseen Israa Fadhil , Alomar Mohammed , Lenihan Daniel , Dent Susan , Lyon Alexander R.
Published: September 2022

Background

Regional variations in cardiovascular disease (CVD) and CVD management are well known. However, there is limited information on geographical variations in the discipline of Cardio-Oncology, including both the nature of CVD in patients with cancer and its management. Furthermore, during the recent COVID-19 pandemic, CV care for patients was disrupted resulting in an unknown impact on cardio-oncology services.

Objective

The aim of this study was to identify the regional variations in the management of CVD among patients with cancer and the impact of the COVID-19 pandemic on the selection of cardiovascular drugs in cardio-oncology.

Methods

An online survey was conducted by the Iraq Chapter of the International Cardio-Oncology Society (IC-OS). The survey was shared with cardiologists and oncologists in all seven continents to identify whether regional variations exist in cardio-oncology daily practice.

Results

From April to July 2021, 140 participants responded to the survey, including cardiologists (72.9%) and oncologists (27.1%). Most of the respondents were from the Middle East (26.4%), North America (25%), Latin America and the Caribbean (25%), and Europe (20.7%). Baseline CV risk assessment in patients with cancer using the HFA/IC-OS score was reported in 75.7% of respondents (78.4% cardiologists and 68.4% oncologists). Hypertension was the most common CVD treated by the survey respondents globally (52.1%) unlike in Europe where heart failure was the most prominent CVD (51.7%). The blood pressure cutoff value to initiate hypertension management is >140/90 mmHg globally (72.9%), but in North America (48.6%) it was >130/80 mmHg. In the Middle East, 43.2% of respondents do not use cardioprotective medication. During the COVID-19 pandemic, 10.7% of respondents changed their practice, such as switching from prescribing ACEI to ARB. Apixaban is the main anticoagulant used in patients with cancer (32.9%); however, in cancer patients with COVID-19 infection, the majority used enoxaparin (31.4%).

Conclusion

More than three-quarters of cardiologists and oncologists responding to the survey are using HFA/IC-OS proformas. The survey showed regional variations in the management of CVD on different continents. The use of cardioprotective agents was limited in some regions including the Middle East. COVID-19 pandemic impacted daily practice on the selection and switching of cardiovascular drugs including ACEI/ARB and the choice of anticoagulants.
Small-volume monogenetic igneous landforms and edifices statistics (SMILES): A catalog of representative mafic volcanic landforms to enable quantitative remote identification
Authors: Nolan Joseph A. , Graettinger Alison H.
Published: September 2022

Accurate classification of terrestrial and non-terrestrial volcanic landforms requires a robust suite of morphometric parameters. The Small-volume Monogenetic Igneous Landforms and Edifices Statistics (SMILES) catalog contains the morphometric characterizations of mafic small-volume volcanic landforms and was created using uncrewed aerial system photogrammetry, open-source LiDAR, and digital elevation model repositories. This study analyzed 20 simple maars, 22 lava collapse features, 24 ring scoria cones, and 24 spatter landforms (fissure and point source spatter ramparts), using high-resolution (<0.1–5 m/pixel) digital elevation models to establish what dimensionless morphometric parameters enable remote identification of the studied landforms. Parameters include isoperimetric circularity, depth ratio (crater depth/major chord), interior slope angles, as well as crater to base ratios for the area, perimeter, and major chord lengths. Landforms were limited to a basal width of <2 km and <1 km3 for scoria cones and spatter landforms, and a major chord of 2 km or less for lava collapse features and maars. Simple maars have an aspect ratio (AR) (>0.74), isoperimetric circularity (IC) (>0.90), interior slope angle (<47°), and depth ratio (<0.26) creating a distinct range of morphometric parameters. Lava collapse features exhibit wider variability in AR (0.26–0.95), IC (0.46–0.98), interior slope angle (up to 16–86°), and depth ratio (0.25–0.52). Scoria cone craters have a distinct range of AR (>0.54), IC (>0.81), interior slope angle (<34°), and lower depth ratio (<0.25). Spatter landforms have a wider range of variability in AR (0.25–0.94), IC (0.43–0.98), interior slope angle (<63°), and depth ratio (0.04–0.37). Scoria cones have lower crater/base area ratios and lower crater/base perimeter ratios than spatter landforms. This study demonstrates that while an individual parameter is not diagnostic for recognizing small-volume mafic volcanic landforms remotely, a suite of parameters is. The SMILES catalog demonstrates the value of evaluating populations of similar landforms using higher-resolution datasets to establish diagnostic suites of dimensionless parameters, to enable accurate and positive remote identification of volcanic landforms. The technique used in this study can be applied to other volcanic and non-volcanic landforms on Earth, as well as non-terrestrial targets.
Mechanisms of deep oil–gas accumulation: New insights from the Carboniferous Central Depression, Junggar Basin, China
Authors: Ablimiti Yiming , He Wenjun , Li Na , Ma Delong , Liu Hailei , Bian Baoli , Ding Xiujian , Jiang Mengya , Wang Jiangtao , Cao Jian
Published: September 2022

To investigate the mechanisms of deep oil–gas accumulation in superimposed basins in western China, and identify deep oil–gas reserves in the Junggar Basin, this study examined Carboniferous reservoirs in the Central Depression of the basin. We determined the hydrocarbon physical properties and geochemical characteristics, and controlling factors on hydrocarbon accumulation in the deep part of the Central Depression. We present a geological model of oil–gas accumulation based on analog modeling of reservoir formation. The deep hydrocarbons in the study area are mainly light–medium oil and wet natural gas, which were mainly derived from Permian and Carboniferous source rocks. The hydrocarbon source rocks and their thermal evolution led to hydrocarbon accumulation in the study area. Adjacent source–reservoir rocks on both sides of faults were key to vertical hydrocarbon migration and multi-stage charging. Suitable reservoir–cap rock assemblages were also important for reservoir preservation. The hydrocarbon accumulation model involves a source–reservoir link along faults, late charging, and paleo-uplifts. The reservoir types include those linked to source rocks by large-scale faults and those in paleo-uplifts surrounded by oil-generating depressions, which both have good exploration prospects. This accumulation model may be applicable to deep parts of other superimposed basins.
Temporal and spatial distribution characteristics of stratospheric aerosols over xinjiang region based on CALIPSO spaceborne lidar observation
Authors: ZiWei Li , Xiangling Tang
Published: September 2022

Based on level 3 stratosphere aerosol profile data retrieved from CALIPSO during 2007–2018, optical properties of stratospheric aerosols over the Xinjiang China are analyzed. The results are as follows:Firstly, the optical depth of stratospheric aerosol over Xinjiang is considerably higher in spring (0.0006) and summer (0.0009), than in autumn (0.0003) and winter (0.0002). Secondly, the backscattering ratio of stratospheric aerosol particles decreases with the increase of altitude, with the bottom of the stratosphere as the main contributor of the optical depth. Thirdly, for latitudinal distribution (35°–50° north latitude), the backscattering ratio gradually increases from south to north, with an average value that reaches 0.0013 × 10–3 km−1sr−1 at maximum in May and 0.0003 × 10–3 km−1sr−1 at minimum in January, October and December.
Migrant parents at high school: Exploring new opportunities for involvement
Authors: Melnikova Julia
Published: September 2022

This article examines the at-school opportunities Norwegian high schools provide for involving migrant parents in their children’s education. The legal and societal expectations of systematic school-home cooperation with all parents at this time of transition to higher education or employment are relatively new in Norway. Thus, how schools act on these expectations as they meet migrant parents is under-researched. To address this gap, interviews with four leaders of three high schools with different sociocultural profiles and observations of meetings with parents at one of the schools were conducted as a part of this study. Examined through a Bourdieusian lens, parental involvement—or rather traditional lack of at-school parental involvement outside crises—can be interpreted as a form of high-school doxa. This unquestionable truth is now challenged as more rights are granted to parents, and new heterodox beliefs and discourses about parents of adolescents at school emerge. At the same time, the schools in the focus of this study appear to have limited room for imagining forms and content of non-crisis communication with the home, especially when parents do not directly claim their rights, as is true for many migrant families. This study thus contributes to the existing research on parental involvement and home-school relations by emphasizing the need for a professional discussion on more equitable and better situated forms of engaging parents, as well as the school’s areas of responsibility in including families in educational communities.
An integrated RNA sequencing and network pharmacology approach reveals the molecular mechanism of dapagliflozin in the treatment of diabetic nephropathy
Authors: Bai Zhenyu , Xie Ting , Liu Tianhao , Chen Zedong , Yu Linde , Zhang Chao , Luo Jincheng , Chen Liguo , Zhao Xiaoshan , Xiao Ya
Published: September 2022

Dapagliflozin, an inhibitor of sodium-glucose cotransporter 2 (SGLT2), is a new type of oral hypoglycemic drugs which can promote glucose excretion in the kidney. Studies have shown that dapagliflozin has renoprotective effect in the treatment of type 2 diabetes. However, the underlying mechanism remains unclear. Here, we combined integrated RNA sequencing and network pharmacology approach to investigate the molecular mechanism of dapagliflozin for diabetic nephropathy (DN). Dapagliflozin significantly relieved glucose intolerance, urinary albumin/creatinine ratio (UACR) and renal pathological injuries of db/db mice. The LncRNA and mRNA expression in kidney tissues from control group (CR), db/db group (DN) and dapagliflozin group (DG) were assessed by RNA sequencing. We identified 7 LncRNAs and 64 mRNAs common differentially expressed in CR vs DN and DN vs DG, which were used to construct co-expression network to reveal significantly correlated expression patterns in DN. In addition, network pharmacology was used to predict the therapeutic targets of dapagliflozin and we constructed component-target-pathway network according to the results of RNA sequencing and network pharmacology. We found that SMAD9, PPARG, CD36, CYP4A12A, CYP4A12B, CASP3, H2-DMB2, MAPK1, MAPK3, C3 and IL-10 might be the pivotal targets of dapagliflozin for treating DN and these genes were mainly enriched in pathways including TGF-β signaling pathway, PPAR signaling pathway, Chemokine signaling pathway, etc. Our results have important implication and provide novel insights into the protective mechanism of dapagliflozin for treating DN.