bluuebunny/crossref_metadata_2025 huggingface dataset:
Cocculus hirsutus (L.) W.Theob. (Menispermaceae): A Review on Traditional Uses, Phytochemistry and Pharmacological Activities
Authors: Logesh Rajan , Das Niranjan , Adhikari-Devkota Anjana , Devkota Hari Prasad
Published: November 2020

Background:Cocculus hirsutus (L.) W.Theob. (Menispermaceae) is a perennial climber distributed mostly in tropical and subtropical areas. The main aim of this article is to collect and analyze the scientific information related to traditional uses, bioactive chemical constituents and pharmacological activities. Methods: Scientific information on C. hirsutus was retrieved from the online bibliographic databases (e.g. MEDLINE/PubMed, SciFinder, Web of Science, Google Scholar and Scopus). Information regarding traditional uses was also acquired from secondary resources including books and proceedings. Results: Different plant parts of C. hirsutus were reported to be used for the treatment of fever, skin diseases, stomach disorders and urinary diseases. Alkaloids such as jasminitine, hirsutine, cohirsitine and their derivatives along with a few flavonoids, triterpene derivatives and volatile compounds were reported from whole plant or different plant parts. Extracts were evaluated for their antimicrobial, antidiabetic, immunomodulatory and hepatoprotective activities among others. Conclusion: Although widely used in traditional medicines, only a few studies have been performed related to chemical constituents. Most of the biological activity evaluations were carried out using in vitro evaluation methods and only a few studies were carried out in animal models. In the future, properly designed in vivo and clinical studies are necessary to evaluate the pharmacological activities of C. hirsutus along with bioassay-guided studies to isolate and identify the active constituents.
Amine-Containing Membranes with Functionalized Multi-Walled Carbon Nanotubes for CO2/H2 Separation
Authors: Yang Yutong , Han Yang , Pang Ruizhi , Ho W.S. Winston
Published: November 2020

Amine-containing mixed-matrix membranes incorporated with amino-functionalized multi-walled carbon nanotubes (AF-MWNTs) were synthesized for CO2/H2 separation based on the facilitated transport mechanism. AF-MWNTs were chosen primarily as the mechanical reinforcing filler to enhance the membrane stability. At 107 °C and 0.2-MPa feed pressure, the membrane incorporated with 10 wt.% AF-MWNTs showed a CO2 permeability of 3196 Barrers and a CO2/H2 selectivity of 205. At the higher feed pressure of 1.5 MPa, owing to the carrier saturation phenomenon, the same membrane exhibited reduced transport performance with a CO2 permeability of 776 Barrers and a CO2/H2 selectivity of 31. These separation performances at both the low and high feed pressures were well above the theoretical upper bound. Furthermore, the incorporation of 10 wt.% AF-MWNTs led to a significant improvement on membrane stability. The transport performance and selective layer thickness of this membrane maintained for 100 h, which suggested that the incorporation of AF-MWNTs improved the resistance to membrane compaction upon a high feed pressure. Therefore, this work is considered as one of the crucial steps to enable the application of facilitated transport membranes to high-pressure gas processing such as syngas purification.
The Effect of Preliminary Thermomechanical Processing on the Kinetics of Localized Plasticity Autowaves in Trip Steel
Authors: Orlova Dina V. , Danilov Vladimir I. , Gorbatenko Vadim V. , Danilova Lidiya V. , Shlyakhova Galina V. , Zuev Lev B.
Published: November 2020

The kinetics of the martensitic transformation fronts in transformation-induced plasticity (TRIP) steel was studied in relation to preliminary thermomechanical treatment using the digital image correlation method. It was found that warm rolling of steel to 40–63% reduction significantly increases the stress of the onset of strain-induced phase transformation and changes the loading curve stages. The strain-induced phase transformation in TRIP steel occurring through the formation of Lüders and Portevin–Le Chatelier bands is shown to be an autowave process of localized plasticity. The austenite → martensite transformation at the elastic-plastic transition occurs in the form of several switching localized plasticity autowaves. At the jerky flow stage, excitation autowaves of localized plasticity are generated and propagate repeatedly until the strain-induced austenite → martensite transformation is completed. It is shown for the first time that the sources of excitation autowaves in the material are the sites of nucleation or annihilation of switching autowaves.
TIG Stainless Steel Molten Pool Contour Detection and Weld Width Prediction Based on Res-Seg
Authors: Wang Yiming , Han Jing , Lu Jun , Bai Lianfa , Zhao Zhuang
Published: November 2020

As the basic visual morphological characteristics of molten pool, contour extraction plays an important role in on-line monitoring of welding quality. The limitations of traditional edge detection algorithms make deep learning play a more important role in the task of target segmentation. In this paper, a molten pool visual sensing system in a tungsten inert gas welding (TIG) process environment is established and the corresponding molten pool image data set is made. Based on a residual network, a multi-scale feature fusion semantic segmentation network Res-Seg is designed. In order to further improve the generalization ability of the network model, this paper uses deep convolutional generative adversarial networks (DCGAN) to supplement the molten pool data set, then performs color and morphological data enhancement before network training. By comparing with other traditional edge detection algorithms and semantic segmentation network, it is verified that the scheme has high accuracy and robustness in the actual welding environment. Moreover, a back propagation (BP) neural network is used to predict the weld width, and a fitting test is carried out for the pixel width of the molten pool and its corresponding actual weld width. The average testing error is less than 0.2 mm, which meets the welding accuracy requirements.
Study on Tooth Interior Fatigue Fracture Failure of Wind Turbine Gears
Authors: Bai Houyi , Zhu Caichao , Zhou Ye , Chen Xiaojin , Feng Houbin , Ye Wei
Published: November 2020

Gear contact fatigue has becoming a bottleneck restricting the safety and reliability of wind turbine transmission systems. Tooth interior fatigue fracture (TIFF) failure is commonly observed in case-hardened wind turbine gears. In this work, a contact fatigue model is developed to investigate the effect of design parameters and material properties on TIFF of wind turbine gears. The sub-surface stress field is obtained by superposing the load-introduced stress and initial residual stress. The hardness gradient of the hardened layer is measured by Vickers hardness tests. Based upon the stress field and material properties, a fatigue parameter analysis is presented to characterize the risk of TIFF by using the Dang Van multiaxial fatigue criterion. Results show that the risk of TIFF increases with increasing external load. Increasing pressure angle and residual compressive stress could reduce TIFF risk. The combination of high surface hardness, low core hardness, and large effective case depth could inhibit the crack initiation.
Beta Cell Physiological Dynamics and Dysfunctional Transitions in Response to Islet Inflammation in Obesity and Diabetes
Authors: Cerf Marlon E.
Published: November 2020

Beta cells adapt their function to respond to fluctuating glucose concentrations and variable insulin demand. The highly specialized beta cells have well-established endoplasmic reticulum to handle their high metabolic load for insulin biosynthesis and secretion. Beta cell endoplasmic reticulum therefore recognize and remove misfolded proteins thereby limiting their accumulation. Beta cells function optimally when they sense glucose and, in response, biosynthesize and secrete sufficient insulin. Overnutrition drives the pathogenesis of obesity and diabetes, with adverse effects on beta cells. The interleukin signaling system maintains beta cell physiology and plays a role in beta cell inflammation. In pre-diabetes and compromised metabolic states such as obesity, insulin resistance, and glucose intolerance, beta cells biosynthesize and secrete more insulin, i.e., hyperfunction. Obesity is entwined with inflammation, characterized by compensatory hyperinsulinemia, for a defined period, to normalize glycemia. However, with chronic hyperglycemia and diabetes, there is a perpetual high demand for insulin, and beta cells become exhausted resulting in insufficient insulin biosynthesis and secretion, i.e., they hypofunction in response to elevated glycemia. Therefore, beta cell hyperfunction progresses to hypofunction, and may progressively worsen towards failure. Preserving beta cell physiology, through healthy nutrition and lifestyles, and therapies that are aligned with beta cell functional transitions, is key for diabetes prevention and management.
Metabolic Signatures of the Exposome—Quantifying the Impact of Exposure to Environmental Chemicals on Human Health
Authors: Orešič Matej , McGlinchey Aidan , Wheelock Craig E. , Hyötyläinen Tuulia
Published: November 2020

Human health and well-being are intricately linked to environmental quality. Environmental exposures can have lifelong consequences. In particular, exposures during the vulnerable fetal or early development period can affect structure, physiology and metabolism, causing potential adverse, often permanent, health effects at any point in life. External exposures, such as the “chemical exposome” (exposures to environmental chemicals), affect the host’s metabolism and immune system, which, in turn, mediate the risk of various diseases. Linking such exposures to adverse outcomes, via intermediate phenotypes such as the metabolome, is one of the central themes of exposome research. Much progress has been made in this line of research, including addressing some key challenges such as analytical coverage of the exposome and metabolome, as well as the integration of heterogeneous, multi-omics data. There is strong evidence that chemical exposures have a marked impact on the metabolome, associating with specific disease risks. Herein, we review recent progress in the field of exposome research as related to human health as well as selected metabolic and autoimmune diseases, with specific emphasis on the impacts of chemical exposures on the host metabolome.
Advanced Top-Down Fabrication for a Fused Silica Nanofluidic Device
Authors: Morikawa Kyojiro , Kazoe Yutaka , Takagi Yuto , Tsuyama Yoshiyuki , Pihosh Yuriy , Tsukahara Takehiko , Kitamori Takehiko
Published: November 2020

Nanofluidics have recently attracted significant attention with regard to the development of new functionalities and applications, and producing new functional devices utilizing nanofluidics will require the fabrication of nanochannels. Fused silica nanofluidic devices fabricated by top-down methods are a promising approach to realizing this goal. Our group previously demonstrated the analysis of a living single cell using such a device, incorporating nanochannels having different sizes (102–103 nm) and with branched and confluent structures and surface patterning. However, fabrication of geometrically-controlled nanochannels on the 101 nm size scale by top-down methods on a fused silica substrate, and the fabrication of micro-nano interfaces on a single substrate, remain challenging. In the present study, the smallest-ever square nanochannels (with a size of 50 nm) were fabricated on fused silica substrates by optimizing the electron beam exposure time, and the absence of channel breaks was confirmed by streaming current measurements. In addition, micro-nano interfaces between 103 nm nanochannels and 101 μm microchannels were fabricated on a single substrate by controlling the hydrophobicity of the nanochannel surfaces. A micro-nano interface for a single cell analysis device, in which a nanochannel was connected to a 101 μm single cell chamber, was also fabricated. These new fabrication procedures are expected to advance the basic technologies employed in the field of nanofluidics.
A Novel Algorithm for Routing Paths Selection in Mesh-Based Optical Networks-on-Chips
Authors: Yang Xiao-Ping , Song Ting-Ting , Ye Yi-Chen , Liu Bo-Cheng , Yan Hua , Zhu Yun-Chao , Zheng Yan-Li , Liu Yong , Xie Yi-Yuan
Published: November 2020

Optical networks-on-chips (ONoCs) is an effective and extensible on-chip communication technology, which has the characteristics of high bandwidth, low consumption, and low delay. In the design process of ONoCs, power loss is an important factor for limiting the scalability of ONoCs. Additionally, the optical signal-to-noise ratio (OSNR) is an index to measure the quality of ONoCs. Nowadays, the routing algorithm commonly used in ONoCs is the dimension-order routing algorithm, but the routing paths selected by the algorithm have high power loss and crosstalk noise. In this paper, we propose a 5×5 all-pass optical router model for two-dimensional (2-D) mesh-based ONoCs. Based on the general optical router model and the calculation models of power loss and crosstalk noise, a novel algorithm is proposed in ordder to select the routing paths with the minimum power loss. At the same time, it can ensure that the routing paths have the approximately optimal OSNR. Finally, we employ the Cygnus optical router to verify the proposed routing algorithm. The results show that the algorithm can effectively reduce the power loss and improve the OSNR in the case of network sizes of 5×5 and 6×6. With the increase of the optical network scale, the algorithm can perform better in reducing the power loss and raising the OSNR.
Combined Effect of Naturally-Derived Biofilm Inhibitors and Differentiated HL-60 Cells in the Prevention of Staphylococcus aureus Biofilm Formation
Authors: Reigada Inés , Guarch-Pérez Clara , Patel Jayendra Z. , Riool Martijn , Savijoki Kirsi , Yli-Kauhaluoma Jari , Zaat Sebastian A. J. , Fallarero Adyary
Published: November 2020

Nosocomial diseases represent a huge health and economic burden. A significant portion is associated with the use of medical devices, with 80% of these infections being caused by a bacterial biofilm. The insertion of a foreign material usually elicits inflammation, which can result in hampered antimicrobial capacity of the host immunity due to the effort of immune cells being directed to degrade the material. The ineffective clearance by immune cells is a perfect opportunity for bacteria to attach and form a biofilm. In this study, we analyzed the antibiofilm capacity of three naturally derived biofilm inhibitors when combined with immune cells in order to assess their applicability in implantable titanium devices and low-density polyethylene (LDPE) endotracheal tubes. To this end, we used a system based on the coculture of HL-60 cells differentiated into polymorphonuclear leukocytes (PMNs) and Staphylococcus aureus (laboratory and clinical strains) on titanium, as well as LDPE surfaces. Out of the three inhibitors, the one coded DHA1 showed the highest potential to be incorporated into implantable devices, as it displayed a combined activity with the immune cells, preventing bacterial attachment on the titanium and LDPE. The other two inhibitors seemed to also be good candidates for incorporation into LDPE endotracheal tubes.
Response of Coral Reef Dinoflagellates to Nanoplastics under Experimental Conditions Suggests Downregulation of Cellular Metabolism
Authors: Ripken Christina , Khalturin Konstantin , Shoguchi Eiichi
Published: November 2020

Plastic products contribute heavily to anthropogenic pollution of the oceans. Small plastic particles in the microscale and nanoscale ranges have been found in all marine ecosystems, but little is known about their effects upon marine organisms. In this study, we examine changes in cell growth, aggregation, and gene expression of two symbiotic dinoflagellates of the family Symbiodiniaceae, Symbiodinium tridacnidorum (clade A3), and Cladocopium sp. (clade C) under exposure to 42-nm polystyrene beads. In laboratory experiments, the cell number and aggregation were reduced after 10 days of nanoplastic exposure at 0.01, 0.1, and 10 mg/L concentrations, but no clear correlation with plastic concentration was observed. Genes involved in dynein motor function were upregulated when compared to control conditions, while genes related to photosynthesis, mitosis, and intracellular degradation were downregulated. Overall, nanoplastic exposure led to more genes being downregulated than upregulated and the number of genes with altered expression was larger in Cladocopium sp. than in S. tridacnidorum, suggesting different sensitivity to nano-plastics between species. Our data show that nano-plastic inhibits growth and alters aggregation properties of microalgae, which may negatively affect the uptake of these indispensable symbionts by coral reef organisms.
Volatile-Mediated Inhibitory Activity of Rhizobacteria as a Result of Multiple Factors Interaction: The Case of Lysobacter capsici AZ78
Authors: Vlassi Anthi , Nesler Andrea , Parich Alexandra , Puopolo Gerardo , Schuhmacher Rainer
Published: November 2020

Plant beneficial rhizobacteria may antagonize soilborne plant pathogens by producing a vast array of volatile organic compounds (VOCs). The production of these compounds depends on the medium composition used for bacterial cell growth. Accordingly, Lysobacter capsici AZ78 (AZ78) grown on a protein-rich medium was previously found to emit volatile pyrazines with toxic activity against soilborne phypathogenic fungi and oomycetes. However, the discrepancy between the quantity of pyrazines in the gaseous phase and the minimum quantity needed to achieve inhibition of plant pathogens observed, lead us to further investigate the volatile-mediated inhibitory activity of AZ78. Here, we show that, besides VOCs, AZ78 cells produce ammonia in increased amounts when a protein-rich medium is used for bacterial growth. The production of this volatile compound caused the alkalinization of the physically separated culture medium where Rhizoctonia solani was inoculated subsequently. Results achieved in this work clearly demonstrate that VOC, ammonia and the growth medium alkalinization contribute to the overall inhibitory activity of AZ78 against R. solani. Thus, our findings suggest that the volatile-mediated inhibitory activity of rhizobacteria in protein-rich substrates can be regarded as a result of multiple factors interaction, rather than exclusively VOCs production.
Effects of Potassium Propyl Xanthate Collector and Sodium Sulfite Depressant on the Floatability of Chalcopyrite in Seawater and KCl Solutions
Authors: Arancibia-Bravo María P. , López-Valdivieso Alejandro , Flores Luís F. , Cisternas Luís A.
Published: November 2020

This study demonstrates the effects of a potassium propyl xanthate (PPX) collector and sodium sulfite (Na2SO3) depressant on pure chalcopyrite in synthetic seawater (SSW) and potassium chloride (KCl) solutions. SSW solutions with 35 g/L of salt and 0.01-M KCl were used for microflotation and zeta potential tests. Particles sized between 200# and 100# (75–150 µm) were used, and the pH was between 8.0 and 8.5. The surface of the mineral and its interaction with the collector were characterized using Raman spectrometry. The zeta potential of the chalcopyrite was measured in KCl solution at a pH range of 3–12 using the collector and depressant at a monodispersed particle size of 635# (20 µm). The results indicate that the floatability of chalcopyrite is not affected by the presence of PPX collectors in SSW solutions. SSW provides better recoveries than KCl solutions with values of 91.42% and 88.15%, respectively. The Na2SO3 depressant does not hinder the mineral floatability throughout the entire concentration range used; however, special care must be taken when adjusting the pH range to avoid increasing the zeta potential.
On the Calculation of Van der Waals Force between Clay Particles
Authors: Shang Xiang-Yu , Zhao Kang , Qian Wan-Xiong , Zhu Qi-Yin , Zhou Guo-Qing
Published: November 2020

Complex physical–chemical interactions between clay particles including the van der Waals force control the macroscopic behaviors of clay. The calculation of van der Waals force is essential in the discrete element method (DEM) that has been widely used to enhance the understanding of the behavior of clay. Due to its high computational efficiency, a plate-wall model developed in the literature was adopted to obtain the van der Waals force between the neighboring clay particles approximately in the published DEM simulations. However, different choices of the ideal wall result in different magnitudes as well as directions of total van der Waals forces. To investigate the effect, a new rigorous plate-plate model was put forward and solved using an optimized Cotes integration method. Based on the comparison between the calculated results based on plate-wall and plate-plate model, the above effect was analyzed for the cases of face-face, edge-edge and edge-face contact types. Then, necessary advice for the reasonable use of the ideal-wall model was given accordingly.
Provenance Shift during the Plio-Pleistocene in the Vertex of Yangtze Delta and Its Geomorphological Implications
Authors: Yu Junjie , Yue Wei , Liu Ping , Peng Bo , Zhang Jie , Sun Dandan , Wang Jilong , Lv Hailong , Chen Jing
Published: November 2020

One of the key issues of the Source-to-Sink process is revealing the geomorphological evolutions of large rivers from the perspective of river sink areas. This study aims to reveal the provenance change near the vertex of the Yangtze delta during the late Cenozoic and provide insight into the Yangtze channelization into the sea due to regional tectonic subsidence. Heavy minerals and zircon geochronology in the Plio-Pleistocene sediments of the vertex of the modern Yangtze delta (core RGK15) reveal that a significant provenance shift occurred at ~2.6 Ma (the beginning of the Pleistocene). During the Pliocene, ultra-stable heavy minerals and pre-Mesozoic zircon grains predominated in the sediments, probably derived from contemporary outcrops of sedimentary rock that were widely distributed in the delta and its surrounding area. They are completely different from those in the Pliocene sediments of the south delta, indicating that decentralized, local, small watersheds dominated the Yangtze delta during the Pliocene. This resulted from the relatively elevated terrain of this region due to the adjacent ancient Zhejiang–Fujian Uplift (ZFU) at that time. However, diversified heavy minerals and zircon geochronology similar to those of the modern upper Yangtze fingerprints occur in the Pleistocene sediments of core RGK15, implying that a significant provenance shift to the Yangtze River occurred here at ~2.6 Ma. The provenance shift recorded by the cores in the south delta mainly occurred at ~1.2 Ma, indicating that the Yangtze River channel was dragged southward with the further subsidence of the ancient Zhejiang–Fujian Uplift. This study reveals the southward migration process of the Yangtze River channel with the regional tectonic subsidence from the perspective of provenance evolution, which contributes to an understanding of when the Yangtze River channelized into the sea.
Jigging: A Review of Fundamentals and Future Directions
Authors: Ambrós Weslei M.
Published: November 2020

For centuries, jigging has been a workhorse of the mineral processing industry. Recently, it has also found its way into the recycling industry, and the increasing concerns related to water usage has led to a renewed interest in dry jigging. However, the current scenario of increasing ore complexity and the advent of smart sensor technologies, such as sensor-based sorting (SBS), has established increasingly challenging levels for traditional concentration methods, such as jigging. Against this background, the current review attempts to summarize and refresh the key aspects and concepts about jigging available in the literature. The configuration, operational features, applications, types, and theoretical models of jigging are comprehensively reviewed. Three promising paths for future research are presented: (1) using and adapting concepts from granular physics in fundamental studies about the stratification phenomena in jigs; (2) implementing advanced control functions by using machine vision and multivariate data analysis and; (3) further studies to unlock the potential of dry jigs. Pursuing these and other innovations are becoming increasingly essential to keep the role of jigging as a valuable tool in future industry.
Flocculation of Clay Suspensions by Anionic and Cationic Polyelectrolytes: A Systematic Analysis
Authors: Shakeel Ahmad , Safar Zeinab , Ibanez Maria , van Paassen Leon , Chassagne Claire
Published: November 2020

The characteristics of clayey suspensions, majorly composed of quartz microparticles, in the presence of anionic and cationic polyelectrolytes were investigated using different techniques. A wide range of clay concentrations was used, i.e., from 0.07 to 1000 g/L for different experimental techniques, based on the fact that the clay concentration possible to analyze with selected experimental methods was significantly different. The optimum flocculant to clay ratio was defined as the ratio that gives the fastest initial floc growth by static light scattering or fastest initial settling velocity by settling column experiments. In case of anionic polyelectrolyte, it was observed that the optimum flocculant dose depends on the amount of cations present in the system. For suspensions made with demi-water, a lower optimum flocculant dose (<1 mg/g) than for suspensions prepared in tap water (2.28 mg/g) was observed. At these lower salinities, the supernatant remained turbid in all the experiments and was, therefore, not a good measure for optimal anionic based flocculation. The equilibrium floc size at a given shear rate was found to be independent on the shear history of the floc and only dependent on the current applied shear. This was confirmed by both light scattering and rheological analysis. In case of cationic polyelectrolyte, the optimum flocculant ratio (5–6 mg/g) corresponded to the ratio that gives the lowest electrophoretic mobility for each clay concentration and to the ratio that gives the fastest settling velocity for the highest clay concentrations (12–15 g/L), where static light scattering measurements were not possible. All investigation techniques, therefore, proved to be good indicators for predicting the optimum flocculant to clay ratio. For the lowest concentrations (1.75–8.7 g/L) studied by settling column measurements, the optimum flocculant ratio was observed to increase with decreasing clay concentration, for fixed mixing conditions. The optimum flocculant to clay ratio was not always corresponding to the clearest supernatant and the size of flocs at optimum dosage was dependent on the mixing efficiency. The equilibrium floc size at a given shear rate was found to be dependent on the shear history of the floc and the current applied shear. This was confirmed by both light scattering and rheological analysis.
Towards Volatile Organoselenium Compounds with Cost-Effective Synthesis
Authors: Charvot Jaroslav , Pokorný Daniel , Klikar Milan , Jelínková Veronika , Bureš Filip
Published: November 2020

The current portfolio of organoselenium compounds applicable as volatile precursors for atomic layer deposition can be denoted as very limited. Hence, we report herein facile and cost-effective preparation of two bis(trialkylstannyl)selenides as well as one selenole and three bis(trialkylsilyl)selenides. Their syntheses have been optimized to: (i) use readily available and inexpensive starting materials, (ii) involve operationally simple methodology (heating in a pressure vessel), (iii) use a minimum amount of additives and catalysts, and (iv) either exclude additional purification or involve only simple distillation. The chemical structure of prepared Se derivatives was confirmed by multinuclear NMR and GC/MS. Their fundamental thermal properties were investigated by differential scanning calorimetry (DSC) and TGA methods that revealed thermal stability within the range of 160–300 °C.
Vibrational Properties and DFT Calculations of Perovskite-Type Methylhydrazinium Manganese Hypophosphite
Authors: Ciupa-Litwa Aneta , Ptak Maciej , Kucharska Edyta , Hanuza Jerzy , Mączka Mirosław
Published: November 2020

Recently discovered hybrid perovskites based on hypophosphite ligands are a promising class of compounds exhibiting unusual structural properties and providing opportunities for construction of novel functional materials. Here, we report for the first time the detailed studies of phonon properties of manganese hypophosphite templated with methylhydrazinium cations ([CH3NH2NH2][Mn(H2PO2)3]). Its room temperature vibrational spectra were recorded for both polycrystalline sample and a single crystal. The proposed assignment based on Density Functional Theory (DFT) calculations of the observed vibrational modes is also presented. It is worth noting this is first report on polarized Raman measurements in this class of hybrid perovskites.
Biomass: A Renewable Source of Fuels, Chemicals and Carbon Materials
Authors: Serrano-Ruiz Juan Carlos
Published: November 2020

Fossil fuels have been long used as a source of carbon for synthetizing the fuels, chemicals, and carbon-based materials we use on a daily basis [...]
An Overview of the Role of Adipokines in Cardiometabolic Diseases
Authors: Farkhondeh Tahereh , Llorens Silvia , Pourbagher-Shahri Ali Mohammad , Ashrafizadeh Milad , Talebi Marjan , Shakibaei Mehdi , Samarghandian Saeed
Published: November 2020

Obesity as an independent risk factor for cardiovascular diseases (CVDs) leads to an increase in morbidity, mortality, and a shortening of life span. The changes in heart structure and function as well as metabolic profile are caused by obese people, including those free of metabolic disorders. Obesity alters heart function structure and affects lipid and glucose metabolism, blood pressure, and increase inflammatory cytokines. Adipokines, specific cytokines of adipocytes, are involved in the progression of obesity and the associated co-morbidities. In the current study, we review the scientific evidence on the effects of obesity on CVDs, focusing on the changes in adipokines. Several adipokines have anti-inflammatory and cardioprotective effects comprising omentin, apelin, adiponectin, and secreted frizzled-related protein (Sfrp-5). Other adipokines have pro-inflammatory impacts on the cardiovascular system and obesity including leptin, tumor necrosis factor (TNF), retinol-binding protein4 (RBP-4), visfatin, resistin, and osteopontin. We found that obesity is associated with multiple CVDs, but can only occur in unhealthy metabolic patients. However, more studies should be designed to clarify the association between obesity, adipokine changes, and the occurrence of CVDs.
In Situ and Real-Time Nanoscale Monitoring of Ultra-Thin Metal Film Growth Using Optical and Electrical Diagnostic Tools
Authors: Colin Jonathan , Jamnig Andreas , Furgeaud Clarisse , Michel Anny , Pliatsikas Nikolaos , Sarakinos Kostas , Abadias Gregory
Published: November 2020

Continued downscaling of functional layers for key enabling devices has prompted the development of characterization tools to probe and dynamically control thin film formation stages and ensure the desired film morphology and functionalities in terms of, e.g., layer surface smoothness or electrical properties. In this work, we review the combined use of in situ and real-time optical (wafer curvature, spectroscopic ellipsometry) and electrical probes for gaining insights into the early growth stages of magnetron-sputter-deposited films. Data are reported for a large variety of metals characterized by different atomic mobilities and interface reactivities. For fcc noble-metal films (Ag, Cu, Pd) exhibiting a pronounced three-dimensional growth on weakly-interacting substrates (SiO2, amorphous carbon (a-C)), wafer curvature, spectroscopic ellipsometry, and resistivity techniques are shown to be complementary in studying the morphological evolution of discontinuous layers, and determining the percolation threshold and the onset of continuous film formation. The influence of growth kinetics (in terms of intrinsic atomic mobility, substrate temperature, deposition rate, deposition flux temporal profile) and the effect of deposited energy (through changes in working pressure or bias voltage) on the various morphological transition thicknesses is critically examined. For bcc transition metals, like Fe and Mo deposited on a-Si, in situ and real-time growth monitoring data exhibit transient features at a critical layer thickness of ~2 nm, which is a fingerprint of an interface-mediated crystalline-to-amorphous phase transition, while such behavior is not observed for Ta films that crystallize into their metastable tetragonal β-Ta allotropic phase. The potential of optical and electrical diagnostic tools is also explored to reveal complex interfacial reactions and their effect on growth of Pd films on a-Si or a-Ge interlayers. For all case studies presented in the article, in situ data are complemented with and benchmarked against ex situ structural and morphological analyses.
Two-Dimensional Silicon Carbide: Emerging Direct Band Gap Semiconductor
Authors: Chabi Sakineh , Kadel Kushal
Published: November 2020

As a direct wide bandgap semiconducting material, two-dimensional, 2D, silicon carbide has the potential to bring revolutionary advances into optoelectronic and electronic devices. It can overcome current limitations with silicon, bulk SiC, and gapless graphene. In addition to SiC, which is the most stable form of monolayer silicon carbide, other compositions, i.e., SixCy, are also predicted to be energetically favorable. Depending on the stoichiometry and bonding, monolayer SixCy may behave as a semiconductor, semimetal or topological insulator. With different Si/C ratios, the emerging 2D silicon carbide materials could attain novel electronic, optical, magnetic, mechanical, and chemical properties that go beyond those of graphene, silicene, and already discovered 2D semiconducting materials. This paper summarizes key findings in 2D SiC and provides insight into how changing the arrangement of silicon and carbon atoms in SiC will unlock incredible electronic, magnetic, and optical properties. It also highlights the significance of these properties for electronics, optoelectronics, magnetic, and energy devices. Finally, it will discuss potential synthesis approaches that can be used to grow 2D silicon carbide.
Femtosecond Double-Pulse Laser Ablation and Deposition of Co-Doped ZnS Thin Films
Authors: Lopez-Quintas Ignacio , Rebollar Esther , Ávila-Brande David , Izquierdo Jesús , Bañares Luis , Díaz-Guerra Carlos , Urbieta Ana , Castillejo Marta , Nalda Rebeca , Martín Margarita
Published: November 2020

Nanostructured thin films of Co-doped zinc sulfide were synthesized through femtosecond pulsed laser deposition. The scheme involved ablation of physically mixed Co and ZnS with pairs of ultrashort pulses separated in time in the 0–300 ps range. In situ monitorization of the deposition process was carried out through a simultaneous reflectivity measurement. The crystallinity of generated nanoparticles and the inclusion of Co in the ZnS lattice is demonstrated by transmission electron microscopy and energy dispersive X-ray microanalysis (TEM-EDX) characterization. Surface morphology, Raman response, and photoluminescence of the films have also been assessed. The role of interpulse temporal separation is most visible in the thickness of the films obtained at the same total fluence, with much thicker films deposited with short delays than with individual uncoupled pulses. The proportion of Co in the synthesized doped ZnS nanoparticles is found to be substantially lower than the original proportion, and practically independent on interpulse delay.
Association of Yogurt Consumption with Nutrient Intakes, Nutrient Adequacy, and Diet Quality in American Children and Adults
Authors: Cifelli Christopher J. , Agarwal Sanjiv , Fulgoni Victor L.
Published: November 2020

The popularity of yogurt has increased among consumers due to its perceived health benefits. This study examined the cross-sectional association between yogurt consumption and nutrient intake/adequacy, dietary quality, and body weight in children and adults. National Health and Nutrition Examination Survey 2001–2016 data (n = 65,799) were used and yogurt consumers were defined as those having any amount of yogurt during in-person 24-h diet recall. Usual intakes of nutrients were determined using the National Cancer Institute method and diet quality was calculated using the Healthy Eating Index-2015 (HEI-2015) scores after adjusting data for demographic and lifestyle factors. The data show that approximately 6.4% children and 5.5% adults consume yogurt, with a mean intake of yogurt of 150 ± 3 and 182 ± 3 g/d, respectively. Yogurt consumers had higher diet quality (10.3% and 15.2% higher HEI-2015 scores for children and adults, respectively); higher intakes of fiber, calcium, magnesium, potassium, and vitamin D; and higher percent of the population meeting recommended intakes for calcium, magnesium, and potassium than non-consumers. Consumption of yogurt was also associated with lower body weight, body mass index (BMI), and 23% showed a lower risk of being overweight/obese among adults only. In conclusion, yogurt consumption was associated with higher nutrient intake, nutrient adequacy, and diet quality in both children and adults.
Fennel for Reducing Pain in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Lee Hye Won , Ang Lin , Lee Myeong Soo , Alimoradi Zainab , Kim Eunseop
Published: November 2020

Fennel is used as an alternative treatment for primary dysmenorrhea. This review aims to evaluate the effectiveness and safety of fennel for reducing pain in primary dysmenorrhea. Twenty databases, including English, Korean, Chinese, Japanese, Iranian, and Spanish databases, were searched from inception to 20 October 2020. All randomized controlled trials (RCTs) investigating the effectiveness of fennel for treating primary dysmenorrhea were considered. Two reviewers conducted the data extraction and risk of bias assessment independently. Any discrepancies were resolved through discussion with a third reviewer. A total of 12 studies were included in this review. The pooled results of seven trials showed that the effect of fennel is similar to that of conventional drug therapies in alleviating pain (n = 502, standardized mean difference (SMD): 0.07, 95% confidence interval(CI): −0.08 to 0.21, p < 0.37, I2 = 0%). In comparison with placebo, fennel was seen to have favorable effects on reducing pain in primary dysmenorrhea (n = 468, SMD: −3.27, 95% CI: −5.28 to −1.26, p = 0.001, I2 = 98%). Only three studies assessed adverse events (AEs), and one study reported minor AEs. Although the risk of bias for all the included studies was moderate, potential publication bias was observed due to the presence of a greater number of small studies with favorable effects. This systematic review concludes that fennel is as effective as conventional drug therapies in alleviating pain in primary dysmenorrhea. More studies that include more diverse populations and robust evidence of fennel’s effects will be needed in future research endeavors.
Therapeutic Effects of Morinda citrifolia Linn. (Noni) Aqueous Fruit Extract on the Glucose and Lipid Metabolism in High-Fat/High-Fructose-Fed Swiss Mice
Authors: Inada Aline Carla , Silva Gabriela Torres , Silva Laleska Pâmela Rodrigues da , Alves Flávio Macedo , Filiú Wander Fernando de Oliveira , Asato Marcel Arakaki , Junior Wilson Hino Kato , Corsino Joaquim , Figueiredo Patrícia de Oliveira , Garcez Fernanda Rodrigues , Garcez Walmir Silva , Silva Renée de Nazaré Oliveira da , Santos-Eichler Rosangela Aparecida dos , Guimarães Rita de Cássia Avellaneda , Freitas Karine de Cássia , Hiane Priscila Aiko
Published: November 2020

The aim of this study was to evaluate the therapeutic effects of two different doses (250 and 500 mg/kg) of Morinda citrifolia fruit aqueous extract (AE) in high-fat/high-fructose-fed Swiss mice. The food intake, body weight, serum biochemical, oral glucose tolerance test (OGTT), and enzyme-linked immunosorbent assay (ELISA), as well as histological analyses of the liver, pancreatic, and epididymal adipose tissue, were used to determine the biochemical and histological parameters. The chemical profile of the extract was determined by ultra-fast liquid chromatography–diode array detector–tandem mass spectrometry (UFLC–DAD–MS), and quantitative real-time PCR (qRT-PCR) was used to evaluate the gene expressions involved in the lipid and glucose metabolism, such as peroxisome proliferative-activated receptors-γ (PPAR-γ), -α (PPAR-α), fatty acid synthase (FAS), glucose-6-phosphatase (G6P), sterol regulatory binding protein-1c (SREBP-1c), carbohydrate-responsive element-binding protein (ChREBP), and fetuin-A. Seventeen compounds were tentatively identified, including iridoids, noniosides, and the flavonoid rutin. The higher dose of AE (AE 500 mg/kg) was demonstrated to improve the glucose tolerance; however, both doses did not have effects on the other metabolic and histological parameters. AE at 500 mg/kg downregulated the PPAR-γ, SREBP-1c, and fetuin-A mRNA in the liver and upregulated the PPAR-α mRNA in white adipose tissue, suggesting that the hypoglycemic effects could be associated with the expression of genes involved in de novo lipogenesis.
A Probiotic Lactobacillus gasseri Alleviates Escherichia coli-Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota
Authors: Yun Soo-Won , Kim Jeon-Kyung , Lee Kyung-Eon , Oh Young Joon , Choi Hak-Jong , Han Myung Joo , Kim Dong-Hyun
Published: November 2020

Excessive expression of interleukin (IL)-1β in the brain causes depression and cognitive dysfunction. Herein, we investigated the effect of Lactobacillus gasseri NK109, which suppressed IL-1β expression in activated macrophages, on Escherichia coli K1-induced cognitive impairment and depression in mice. Germ-free and specific pathogen-free mice with neuropsychiatric disorders were prepared by oral gavage of K1. NK109 alleviated K1-induced cognition-impaired and depressive behaviors, decreased the expression of IL-1β and populations of NF-κB+/Iba1+ and IL-1R+ cells, and increased the K1-suppressed population of BDNF+/NeuN+ cells in the hippocampus. However, its effects were partially attenuated by celiac vagotomy. NK109 treatment mitigated K1-induced colitis and gut dysbiosis. Tyndallized NK109, even if lysed, alleviated cognitive impairment and depression. In conclusion, NK109 alleviated neuropsychiatric disorders and colitis by modulating IL-1β expression, gut microbiota, and vagus nerve-mediated gut–brain signaling.
Urinary Sodium and Potassium Levels and Blood Pressure in Population with High Sodium Intake
Authors: Song Da Young , Youn Jiyoung , Kim Kyunga , Sung Joohon , Lee Jung Eun
Published: November 2020

The purpose of this study was to examine the association of urinary sodium-to-creatinine ratio and potassium-to-creatinine ratio with blood pressure in a cross-sectional study comprising Korean adults who participated in the Healthy Twin Study. The participants consisted of 2653 men and women in the Healthy Twin Study aged ≥19 years. Participants’ urinary excretion of sodium, potassium, and creatinine was measured from overnight half-day urine samples. Food intake was assessed using a validated food frequency questionnaire. We examined systolic and diastolic blood pressures according to sodium- or potassium-to-creatinine ratios using the generalized linear model. We determined food groups explaining high urinary sodium- or potassium-to-creatinine ratio using the reduced rank regression and calculated sodium- or potassium-contributing food score. We observed that systolic blood pressure was higher among men and women in the highest quintile of urinary sodium-to-creatinine ratio or sodium-to-potassium ratio than it was in the lowest quintile. Geometric means (95% CIs) of the lowest and the highest quintiles of systolic blood pressure (mmHg) were 113.4 (111.8–115.0) and 115.6 (114.1–117.2; P for trend = 0.02), respectively, for sodium-to-creatinine ratio. The association between urinary sodium-to-creatinine and systolic blood pressure was more pronounced among individuals whose body mass index (BMI) was less than 25 kg/m2 (P for interaction = 0.03). We found that vegetables, kimchi and seaweed intake contributed to high sodium intake and a sodium-contributing food score were associated with increased blood pressure. In our study, we identified the food groups contributing to high sodium intake and found that high urinary sodium levels were associated with increasing blood pressure among Korean adults.
Fructose-Induced Intestinal Microbiota Shift Following Two Types of Short-Term High-Fructose Dietary Phases
Authors: Beisner Julia , Gonzalez-Granda Anita , Basrai Maryam , Damms-Machado Antje , Bischoff Stephan
Published: November 2020

High consumption of fructose and high-fructose corn syrup is related to the development of obesity-associated metabolic diseases, which have become the most relevant diet-induced diseases. However, the influences of a high-fructose diet on gut microbiota are still largely unknown. We therefore examined the effect of short-term high-fructose consumption on the human intestinal microbiota. Twelve healthy adult women were enrolled in a pilot intervention study. All study participants consecutively followed four different diets, first a low fructose diet (< 10 g/day fructose), then a fruit-rich diet (100 g/day fructose) followed by a low fructose diet (10 g/day fructose) and at last a high-fructose syrup (HFS) supplemented diet (100 g/day fructose). Fecal microbiota was analyzed by 16S rRNA sequencing. A high-fructose fruit diet significantly shifted the human gut microbiota by increasing the abundance of the phylum Firmicutes, in which beneficial butyrate producing bacteria such as Faecalibacterium, Anareostipes and Erysipelatoclostridium were elevated, and decreasing the abundance of the phylum Bacteroidetes including the genus Parabacteroides. An HFS diet induced substantial differences in microbiota composition compared to the fruit-rich diet leading to a lower Firmicutes and a higher Bacteroidetes abundance as well as reduced abundance of the genus Ruminococcus. Compared to a low-fructose diet we observed a decrease of Faecalibacterium and Erysipelatoclostridium after the HFS diet. Abundance of Bacteroidetes positively correlated with plasma cholesterol and LDL level, whereas abundance of Firmicutes was negatively correlated. Different formulations of high-fructose diets induce distinct alterations in gut microbiota composition. High-fructose intake by HFS causes a reduction of beneficial butyrate producing bacteria and a gut microbiota profile that may affect unfavorably host lipid metabolism whereas high consumption of fructose from fruit seems to modulate the composition of the gut microbiota in a beneficial way supporting digestive health and counteracting harmful effects of excessive fructose.