bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Battery Levels in Cordless LED Light-curing Units on Properties of Resin Cement and Glass Fiber Post Retention
Authors: Segatto TD , Dolenkei KK , Bernardes P , Soares CJ , Pacheco RR , Raposo LH
Published: August 2024

Purpose:

This study aimed to assess the impact of battery levels in single-peak and multi-peak light-curing units (LCUs) on irradiance, and their effects on glass fiber post push-out bond strength to root dentin and the degree of conversion of dual-cure universal resin cement.

Methods and Materials:

Sixty bovine roots underwent endodontic treatment and were randomly distributed into 6 groups (n=10), formed by combining two LCUs (single-peak and multipeak) and three battery levels (100%, 50%, and 10%). A spectrophotometer measured irradiance (mW/ cm2) and spectral irradiance (mW/cm2/nm). Push-out bond strength (PBS) tests occurred at three root regions (cervical, middle, and apical), with optical and scanning electron microscopy for failure mode analysis. Degree of conversion (DC) was evaluated across the root regions. Data were analyzed using two-way repeated measures ANOVA and the Tukey HSD test. The Fisher exact test verified failure modes (α=0.05).

Results:

As multipeak LCU battery levels decreased, emitted irradiance also diminished, with notable PBS reductions in the apical thirds. Failure modes were influenced by different conditions, primarily exhibiting mixed modes. Battery levels significantly impacted DC in the multipeak LCU, particularly in the cervical region, while the single-peak LCU exhibited DC reduction at the 10% battery level in the cervical region.

Conclusions:

Emitted irradiance, resin cement DC, and glass fiber post bond strength to root dentin may be influenced by varying cordless LCUs and battery levels.
Laser wafer dicing process optimization using the Taguchi approach
Authors: Yang Chih-Fu , Chang Chih-Tsung , Wang Rui-Teng , Kao Jin-Yih , Hsu Chun-Yao
Published: August 2024

This study uses an infrared cutting laser system to dice GaAs wafers. The Taguchi method determines the laser wafer dicing parameters [laser power (W), depth of focus (μm), and platform speed (m/s)] in relation to the dicing yield and single-grain compressive strength. An orthogonal array (L9 33), a signal-to-noise ratio, and an analysis of variance are employed to study the effects of these parameters. The result shows that the laser wafer dicing yield ranges from 85.53% to 95.20%, with laser power accounting for 86.08% of the total variation, making it the most significant factor. Additionally, the wafer dicing yield is positively correlated with grain compressive strength. Grain defects and corner chipping produced during the cutting process will reduce the compressive strength of the grains. Under the optimized laser wafer cutting conditions, the dicing yield and grain compressive strength reached 95.87% and 331.93 N/mm2, respectively.
Respuesta espectral del Obelisco del Bicentenario del Perú, empleando un modelo de sistema continuo
Authors:   Universidad Nacional Intercultural de la Selva Central Juan Santos Atahualpa, Perú., Rupay Vargas Marcos Josue , Loayza Perez Angel Brayan ,   Universidad Nacional Intercultural de la Selva Central Juan Santos Atahualpa, Perú., Buendía Ramos Adriana Carla ,   Universidad Nacional Intercultural de la Selva Central Juan Santos Atahualpa, Perú., Hinostroza Enrique Rossmery Lizbeth ,   Universidad Nacional Intercultural de la Selva Central Juan Santos Atahualpa, Perú., Gonzales Huaman Carlos Bryan ,   Universidad Nacional Intercultural de la Selva Central Juan Santos Atahualpa, Perú.
Published: August 2024

La finalidad de esta investigación fue la de obtener respuesta Espectral del Obelisco del Bicentenario Perú que se ubica en la región de la Libertad; empleando un modelo de sistema continuo de 1 GDL además de los parámetros sísmicos especificados en la Norma E.030 de Diseño Sismorresistente. Para ello, se calcularon respuestas dinámicas como la aceleración y desplazamiento espectral, cortante basal y momento volcante de la estructura. La seudo-aceleración (Sa) resulta en , el seudo-desplazamiento (Sd) en ; la cortante basal ( de y el momento volcante ( de . También, se obtuvo la distribución de la fuerza de inercia que es la siguiente expresión , el cual esencial para determinar las respuestas en la base de la estructura. Concluyendo que, este método es una herramienta muy importante en la ingeniería Sismorresistente, puesto que ofrece los resultados muy aproximados a la realidad; y porque nos permite determinar los parámetros más importantes del diseño sísmico, sin la necesidad de emplear software, ya que en algunas ocasiones es difícil de utilizar en campo.
Turkish ezafe and its Japanese counterparts
Authors: Аврутина А.С. , Шишкин В.А.
Published: August 2024

В статье проводится контрастивный анализ синтаксических систем двух агглютинативных языков, японского и турецкого, с точки зрения турецких изафетов. Исследование показало, что в японском языке существуют аналоги данных определительных синтаксических конструкций, некоторые из них возникли, по всей видимости, в результате влияния китайского языка на японский

The authors perform a contrastive analysis of the syntactic systems of two agglutinative languages, Japanese and Turkish, focusing on Turkish ezafes. The study shows that there are counterparts of these attributive syntactic patterns in Japanese, some of which emerged, apparently, as a result of the influence of the Chinese language on Japanese.
Media communications in the age of cancel culture: crisis management
Authors: Шарифуллина С.В.
Published: August 2024

В статье рассматривается проблема существования современных коммуникаций, которые формировались и продолжают формироваться в особое историческое время – в эпоху культуры отмены. Антикризисные коммуникации – это феномен постковидной эпохи, времени международной нестабильности и продолжающегося противостояния ведущих политических систем. Возможность управления антикризисными коммуникациями – компетенция специалиста – коммуникатора наших дней. В качестве возможных решений существующей проблемы предлагается комплекс мер по стабилизации и укреплению позиций системы медиакоммуникаций в культурном медиаполе России.

The article explores the issue of modern communications that have emerged and continue to develop in a unique historical time – the era of cancel culture. Crisis communication is a phenomenon of the post-COVID era, a time of international instability and ongoing confrontation between leading political systems. The ability to manage crisis communication is a competence of the modern communication specialist. A set of measures to stabilise and strengthen the position of the media communications system in Russia's cultural media field is proposed as possible solutions to the existing problem.
Variability of article categorization of nouns in English proverbs and sayings
Authors: Щербо П.А.
Published: August 2024

Исследование выполнено в рамках когнитивного и функционального подхода к грамматике и интерпретирует типы категоризации существительных формами артикля в английских паремиях. Индивидуализация, классификация и абстрагирование рассматриваются через призму характера паремий и их функционирования в языке. Делаются выводы о приобретении определенным артиклем абстрактно-обобщающего контекстуального значения, о влиянии на употребление артикля исторических и эстетических факторов, признается частотность и важность грамматических и когнитивных принципов категоризации существительных.

The study uses the methods of the cognitive and functional approach to grammar and interprets the categorization of nominal forms by various articles in English proverbs and sayings. Individualization, classification and abstraction are considered with regard to the nature of paroemia and its functioning in the language. Conclusions are drawn about the abstract-generalizing contextual meaning acquired by the definite article, the influence of historical and aesthetic factors on article use, while recognizing the importance of the grammatical and cognitive principles of noun categorization.
The problem-personalistic approach as a tool of historical and pedagogical research (for the anniversary of Alexey Romanov)
Authors: Уткин А.В.
Published: August 2024

В статье представлен анализ научно-педагогической деятельности доктора педагогических наук, профессора Алексея Алексеевича Романова – одного из ведущих исследователей и ярких представителей современной отечественной историко-педагогической науки. Действительный член Академии педагогических и социальных наук и Международной академии наук педагогического образования, Почетный работник высшего профессионального образования РФ, автор 400 научных и учебно-методических работ А. А. Романов является в нашей стране одним из первых исследователей теории и практики отечественной экспериментальной педагогики и свободного воспитания первой трети XX в. Автором рассматриваются характерные особенности применения А. А. Романовым проблемно-персоналистического подхода, позволяющего с помощью анализа наследия известных педагогов и знаковых фигур в истории педагогики проследить содержательные стороны и точки роста научного знания.

This article presents an analysis of the scientific and pedagogical activity of Doctor of Pedagogical Sciences, Professor Alexey Alekseevich Romanov, one of the leading researchers and prominent representatives of modern Russian historical and pedagogical science. Full member of the Academy of Pedagogical and Social Sciences and the International Academy of Sciences of Pedagogical Education, Honorary Worker of Higher Professional Education of the Russian Federation, the author of 400 scientific and educational works A. A. Romanov is one of the first researchers in our country of the theory and practice of Russian experimental pedagogy and free education in the first third of the XX century. The author examines the characteristic features of the A. A. Romanov problem-personalistic approach, which allows analyzing the heritage of famous teachers and iconic figures in the history of pedagogy to trace the negative sides and points of growth in scientific knowledge. The article presents and interprets the results of theoretical, pedagogical and linguistic analysis of scientific texts by Professor A. A. Romanov, which help to identify significant problems in historical and pedagogical science and identify possible directions for further research into the theory and practice of Russian education.
Numerative word formation in Smolensk dialects
Authors: Лунькова Е.С.
Published: August 2024

В статье рассматривается специфика отнумеративного словообразования конкретно-предметных существительных в смоленских говорах. Производные слова сведены в комплексные словообразовательные единицы (типы и гнезда), в работе определяется специфика каждой комплексной единицы. Отмечается особое место сложных существительных среди всех производных данной группы. Устанавливается преобладание производных существительных, мотивированных числительными первого десятка, и делается вывод о значимости этих слов в картине мира смоленского крестьянина.

The article examines the numerative word formation of concrete subject nouns in Smolensk dialects. The derived words are combined into complex word-formation units – types and nests; the specifics of each complex unit are determined in the work. The author emphasizes the unique place of compound nouns among all derivatives in this group; determines the predominance of derived nouns motivated by numerals of the first ten and makes a conclusion about the significance of these words in the world picture of the Smolensk peasant.
Cultural and linguistic components in the structure of bilingual ethnicity
Authors: Салихова Э.А.
Published: August 2024

В статье рассматривается роль регионального фактора в выборе языка и его значимость в структуре этнической идентичности. Изучение этнической идентичности представлено с опорой на социо- и этнопсихолингвистические материалы, обобщение социологических опросов и данных Всероссийской переписи населения. Этноязыковой облик башкир как одного из многочисленных этносов, проживающих на территории полиязычной Российской Федерации, корректируется при непосредственном влиянии родного (национального) языка и культуры. Находит подтверждение тот факт, что в структуре башкирской этничности устойчивость присуща не языковому, а культурному компоненту, при этом велико влияние приобретенных в процессе социализации знаний на образы языкового сознания. Также принимается во внимание их трансформация вследствие межконфессионального и межкультурного контактирования билингвов с представителями иных религий и этносов.

The author examines the role of the regional factor in the choice of language and its significance in the structure of ethnic identity. The study of the latter is based on socio- and ethnopsycholinguistic materials, consolidation of sociological surveys and data from the All-Russian Census. The ethnolinguistic image of the Bashkirs, as one of the numerous ethnic groups living on the territory of the multilingual Russian Federation, is adjusted under the direct influence of the native (national) language and culture. The fact that stability in the structure of Bashkir ethnicity is inherent not in the linguistic but in the cultural component, and the influence of knowledge acquired in the process of socialisation on the images of linguistic consciousness is great. The study also takes into account their transformation due to interfaith and intercultural contact of bilinguals with representatives of other religions and ethnicities. Keywords: identity, native language, symbol, ethnicity, ethnic identifier, language
Exploring Python Programming: A Project Based Learning-Centric Learning Experience
Authors: Karnando Joni , Muskhir Mukhlidi , Luthfi Afdal
Published: August 2024

Information technology has experienced significant developments in science and technology, including programming languages. One of the most popular programming languages today is Python. However, many students still have difficulty learning the Python programming language. These difficulties are caused by the lack of learning media that focus on the Python language, module explanations that are difficult to understand, and a lack of understanding of the library in the Python language. This research aims to create a Python programming language learning module focusing on the project-based Learning (PjBL) approach. The methodology used in this research is Research and Development (R&D). The data needed in this study were collected through questionnaires and learning outcomes exams with a subject of 28 students. The data in the effectiveness aspect is using the T-Test Test. This research results in a valid, practical, and effective PjBL-based Python programming language learning module. This module is considered valid by experts in media aspects with a value of 0.85 and material aspects with a value of 0.89. The practicality of this module is proven through positive responses from lecturers of 88.75%, student responses in the limited test of 88.5%, and the usage trial of 86.96%. Meanwhile, the effectiveness of this module can be seen from the classical completion rate of 82% and the gain score of 57%, and the t-test shows that this module significantly increases student learning outcomes in the Python programming language.
Fields of Interdisciplinarity
Authors: Fisher Evan , Vimal Ruppert
Published: August 2024

This paper provides an empirical account of the problem of interdisciplinarity in the field sciences, considering it as a driver of ontological change. Our case study is an ongoing interdisciplinary research project in environmental science. Its objective is to trace the long-term histories of European old-growth forests. To account for the mechanisms involved when researchers seek to do interdisciplinary science in the field, we describe 1/ four research practices that take advantage of the spatial order of the study site in order to make forests temporal processes knowable, thereby producing a field site crisscrossed by multiple spatiotemporal orders; 2/ those practices geared towards articulating these spatiotemporal orders and the limits faced by the consortium towards their complete integration; 3/ how such articulation transforms the conception of old-growth forests as spaces shaped by historical processes integrating human activities and valued ecological processes. We argue that interdisciplinary research practice in environmental field sciences does not lead to a synthesis of pre-existing domains of knowledge production. Rather, it does tend to transform both the object of study and the disciplines involved. The field, as both an object of study and a research place, becomes a broker toward ontological changes.
PEMETAAN MINAT PESERTA DIDIK BERKEBUTUHAN KHUSUS UNTUK VOCATIONAL PLACEMENT DENGAN APLIKASI IDESMART
Authors: Subagya Subagya , Priyono Priyono , Sari Erma Kumala , Anggrellanggi Arsy
Published: August 2024

Permasalahan yang dihadapi guru Sekolah Luar Biasa (SLB) Negeri Sragen dalam pemetaan minat yaitu keberagaman minat Peserta Didik Berkebutuhan Khusus (PDBK), keberagaman keterampilan vokasi bagi PDBK di SLB, pemetaan minat yang belum didasarkan pada instrumen yang objektif, serta belum adanya pendampingan bagi guru terkait pemetaan minat PDBK untuk vocational placement di SLB. Guru membutuhkan instrumen yang dapat mendukung tugasnya dalam melakukan pemetaan minat untuk vocational placement pada PDBK. Salah satu instrumen digital yang dapat digunakan dalam melakukan pemetaan minat untuk vocational placement pada PDBK adalah aplikasi IDESMART, dengan demikian, tim pengabdian melakukan pendampingan bagi guru dalam melakukan pemetaan minat untuk vocational placement pada PDBK dengan aplikasi IDESMART. Pendampingan pemetaan minat untuk vocational placement pada PDBK dengan aplikasi IDESMART dilaksanakan di SLB Negeri Sragen selaku mitra, yang melibatkan 54 guru di SLB tersebut. Tahapan kegiatan pendampingan terdiri dari tahap persiapan, penyusunan desain pendampingan, pelaksanaan pendampingan, evaluasi, dan pelaporan. Hasil kegiatan pendampingan berupa pemahaman guru terkait kurikulum vokasional di SLB, pemahaman guru terkait konsep minat PDBK, pemahaman guru terkait aplikasi IDESMART, praktek pemanfaatan aplikasi IDESMART, serta kerjasama yang berkelanjutan terkait pendampingan dalam pemetaaan minat PDBK di SLB Negeri Sragen.
Application of ground penetrating radar for evaluating foundation structure condition after earthquake
Authors: Apdeni Risma , Citra Zel , Rifwan Fitra , Putri Prima Yane , Sandra Nevy , Malinda Yosie , Wibowo Paksi Dwiyanto , Ashadi Reza Ferial , Melinda Annisa Prita
Published: August 2024

At the time of seismic activity, the failure of the foundation structure will lead to building damage. When the West Pasaman 2022 earthquake occurred, PT. XYZ is constructing a feed mill tower. Since strong earthquake shocks were felt at the project location, foundation structure evaluation is needed to ensure the safety of the building. Ground Penetrating Radar (GPR) is a tool that is widely used to detect subsurface conditions. This study used GPR as a non-destructive testing technique to evaluate the condition of the foundation structure. The building evaluated is a high-rise steel building, using spun pile foundation. GPR test was carried out in specified lanes, with measurement tracks set at 10 lanes. Any cracks or fractures on the foundation will be indicated by the interruption of waves at the point of the crack or fracture. The GPR test results from readings of electromagnetic wave propagation showed that waves can reach the end of each foundation tested, ranging from 17.10 m to 17.82 m deep. It means that there are no cracks or fractures found on the slab, pile cap, or foundation. Analysis results showed that all slabs and pile caps thicknesses and the detected foundation piles depths are in accordance with the foundation design, which means that the foundations are still in good condition.
Periodization of the Electoral Campaign and its Analytical Support
Authors: Vetrenko Inna A.
Published: August 2024

This article contains the author's approach aimed at separating such concepts as “electoral campaign”, “election campaign”, “election campaign”, “election campaign”, the division of the electoral campaign into chronological stages is proposed and a meaningful description of each of them is given. The author considers several electoral strategies that differ in planning technologies. The most valuable aspect of the article is the characteristic of methods of analytical support of electoral campaigns. The methods of collecting information, processing and analyzing it for each stage of the campaign with a description of their feasibility and practical significance are proposed. The results of the research presented in the article allow us to solve important issues of an applied nature, such as the formation of a strategy and the selection of tactics and technologies for conducting a campaign, identifying the causes of electoral campaign crises at all its stages.
Renewable energy generation in ASEAN: The influence of economic factors, infrastructure, and governance quality
Authors: Pinjaman Saizal , Tee Mcxin , Yun Wong Sing , Nipo Debbra Toria , Zhou Fei , Lu Liangyan
Published: August 2024

This paper examines the relationship between renewable energy (RE) generation, economic factors, infrastructure, and governance quality in ASEAN countries. Based on the Fixed Effects regression model on panel data spanning the years 2002–2021, results demonstrate that domestic capital investment, foreign direct investment, governance effectiveness, and crude oil price exhibit an inverse yet significant relationship with RE generation. An increase in those factors will lead to a decline in RE generation. Meanwhile, economic growth and infrastructure have a positive relationship, which implies that these factors act as stimulants for RE generation in the region. Hence, it is advisable to prioritise policies that foster economic growth, including offering tax breaks specifically for RE projects. Additionally, it’s crucial to streamline governance processes to facilitate infrastructure conducive to RE generation, along with investing in RE infrastructure. This could be achieved by establishing one-stop centres for consolidating permitting processes, which would streamline the often-bureaucratic process. However, given the extensive time period covered, future research should examine the short-term relationship between the variables to address any potential temporal trends between the factors and RE generation.
Particulate matter from wildfire smoke in northern Colorado appears to be associated with conjunctivitis in dogs
Authors: Jones Katrina E. V. , Qu Zhen , Love Kim R. , Daniels Joshua B. , Lappin Michael R. , de Linde Henriksen Michala
Published: August 2024

OBJECTIVE

To evaluate ocular surface parameters in dogs with normal eyes when exposed to 3 different air quality index (AQI) categories corresponding to levels of normal air pollutants (“good,” 0 to 50; “moderate,” 51 to 100) and wildfire smoke (“smoke,” 101 to 150).

ANIMALS

15 privately owned dogs.

METHODS

A prospective cohort study with dogs living in northern Colorado. Ocular surface parameters (conjunctival chemosis and hyperemia, Schirmer tear test-1, tear film break-up time, fluorescein stain, conjunctival microbiology, etc) were evaluated when the AQI was reported in 1 of the 3 categories (good, moderate, and smoke) for 3 consecutive days. The AQI and air pollutant levels (particulate matter < 2.5 μm in diameter [PM2.5], ozone, etc) were retrieved from the AirNow database.

RESULTS

Due to scheduling conflicts, only 7 dogs were examined during the smoke category. Average AQI in the 3 categories were good, 44.1; moderate, 73.7; and smoke, 103.7. The odds for more severe hyperemia and more severe chemosis for smoke were 5.39 and 7,853.02 times the odds, respectively, when compared to good AQI. Additionally, the odds for more severe chemosis were 34,656.62 times the odds for smoke when compared to moderate AQI. A significant relationship was found between chemosis and PM2.5.

CONCLUSIONS

Exposure to increased AQI related to wildfire smoke caused a significant increase in conjunctivitis. The significant relationship between chemosis and PM2.5 could indicate that PM2.5 in wildfire smoke is associated with an inflammatory factor.

CLINICAL RELEVANCE

Preventive measures (eg, use of eyewash, artificial tears, or eye protection) for dogs that are exposed to wildfire smoke should be instituted to decrease the risk of ocular irritation.
Kohlschutter–Tonz syndrome: clinical and genetic insight on patients with ROGDI variant
Authors: Muthaffar Osama , Abdulrahman Lina , Alyazidi Anas , Alotibi Taif
Published: August 2024

Background: Kohlschutter–Tonz syndrome (KTS) is a rare genetically heterogeneous autosomal recessive syn drome initially described in 1974 and characterized by the triad of infantile-onset epilepsy, amelogenesis imperfecta, and developmental delay. KTS patients share a common genetic trait, namely a variant in the ROGDI gene, a gene of unknown function that maps to chromosome 16p13.3.
Methods: Following appropriate ethical and logistical measures, we reviewed literature cases with the ROGDI variant and presented one novel case diagnosed using whole exome sequencing. Clinical, genetic, developmental, and radiological data were reviewed and compared accordingly.
Results: There were 22 studies involving the ROGDI variant, including one additional novel case we reported. Thirteen patients were males, and ten were females. The current age range was 2–24 years. The majority of patients had their first seizure episode between 6 and 12 months. Birth parameters were within normal limits. The majority had unspecified forms of seizures, followed by generalized tonic-clonic and focal tonic-clonic seizures with secondary generalization. Patients with controlled seizures were likely on leveti racetam. Amelogenesis imperfecta and yellowish teeth were distinctive hallmarks. Behavioral problems were observed in one-third of the cases. Electroencephalogram (EEG) and magnetic resonance imaging (MRI) were abnormal in nearly one-third of the cases.
Conclusion: Identifying and drawing conclusive evidence for patients with the ROGDI variant was challenging. Conflicting reports on the efficacy of different anti-seizure medications and the adequate treatment modalities were observed. Potential hallmarks continue to be established. Current evidence can be validated, and a delineation of clinical and molecular findings can be achieved with additional cases.
Movimento Profissão Docente (PD): concepções sobre a formação inicial de professores
Authors: Martini Tatiane Aparecida , Hobold Márcia de Souza
Published: August 2024

Este artigo objetiva identificar as concepções do Movimento Profissão Docente (PD) acerca da formação inicial de professores/as, a partir da seguinte problemática: quais são as concepções do Movimento Profissão Docente (PD) acerca da formação inicial de professores/as? Quanto aos aspectos metodológicos, empregamos uma metodologia de abordagem qualitativa, com procedimentos de pesquisa bibliográfica e documental, de caráter descritivo, analítico e interpretativo. A fim de caracterizar o Movimento, inicialmente buscamos informações nos canais oficiais do PD. Dessa forma, verificamos como ele se configurou, as instituições “parceiras” e a sua vasta produção documental. Assim, elencamos para análise o documento: “O professor que queremos: fatores de qualidade na formação inicial docente” (PDa). Quanto aos resultados, identificamos o embasamento conceitual e ideológico atrelado à pedagogia das habilidades e competências e a intencionalidade de controle sob a formação inicial docente por parte dos aparelhos privados de hegemonia burgueses.
Neural Network-Based Hypersonic Crossflow Transition Model
Authors: Barraza Bryan , Gross Andreas , Leinemann Madlen , Hader Christoph , Fasel Hermann F.
Published: August 2024

A model is proposed for predicting crossflow transition in hypersonic flows. The model is based on transport equations for the crossflow amplification factor and a modified intermittency. The instability onset is estimated with a correlation function. The form of the transport equations is identical to that of typical transport equations for Reynolds-averaged Navier–Stokes (RANS) turbulence models, thus facilitating an easy integration into existing RANS codes. The crossflow amplification factor is estimated from local flow quantities using a neural network. The neural network is trained with a comprehensive database of linear stability theory data. The sensitivity of the amplification factor growth rate prediction to different dimensionless input parameters is evaluated. The input parameters that provide the most-accurate growth rate predictions are selected for the final form of the model. Based on the volume of the training data set, the model is expected to perform reliably for Mach numbers between 5 and 11 and within given upper bounds of the stagnation temperature and pressure. The model is validated for the HiFiRE-5 geometry, a circular cone at angle of attack, and a blunt swept flat plate. The amplification factor distributions obtained from the model are in good agreement with experimental data and linear stability analysis results.
Nonlinear-Model-Inversion Control for Stall-Flutter Suppression of an Airfoil via Camber Morphing
Authors: Li Jinying , Dai Yuting , Wu You , Yang Chao
Published: August 2024

This paper presents a nonlinear-model-inversion control law to suppress stall flutter of an airfoil with active trailing-edge morphing. First, a nonlinear aeroelastic model is proposed utilizing two nonlinear autoregressive neural networks with exogenous inputs , which are used to predict aerodynamic moments on an airfoil due to large-amplitude oscillation and camber morphing, respectively. Afterward, a nonlinear-model-inversion control system is designed upon the mentioned aeroelastic system to suppress stall flutter via the camber morphing. A fluid–structure–control (FSC) coupling strategy is developed with structure and control systems embedded in the high-fidelity computational-fluid-dynamics environment to validate the control effect. The FSC high-fidelity simulations show that the nonlinear-model-inversion controller can suppress pitching oscillation completely, whereas a linear proportional–derivative controller without time delay only performs a limited suppression rate by 25.6%. The flowfield evolution result infers that the active camber morphing can generate a converse training-edge vortex, which counteracts the leading-edge vortex during stall flutter. From the perspective of an energy hysteresis, active camber morphing works well by converting injected aerodynamic energy from positive to negative.
Flow Response of a Laminar Shock–Boundary Layer Interaction to Prescribed Surface Motions
Authors: Fields James L. , Barnes Caleb J. , McNamara Jack J. , Gaitonde Datta V.
Published: August 2024

The response of an impinging laminar shock–boundary layer interaction (SBLI) to prescribed surface motions is investigated numerically at [Formula: see text], [Formula: see text], and a shock-associated pressure ratio of 1.5. Parametric sweeps over classical standing and traveling mode shapes are considered at low-, moderate-, and high-frequency conditions for fluid–structure interaction. The specific values are chosen based on compliant panel deformations and frequencies reported in the literature. At low surface oscillation frequencies, the SBLI responds to the deformations in a quasi-steady fashion, with standing wave forcing displaying both breathing and sloshing of the separated region depending on structural mode shape. As the oscillation frequency is increased, the flow transitions to an unsteady response with pronounced separation bubble undulations in time. Higher-order modes and frequencies lead to the largest reductions in the time-mean separation bubble size, more so with traveling surface waves. Modal decompositions show that pressure fluctuations, which arise due to dynamic interaction with the surface, persist downstream and increase in amplitude with the surface oscillation frequency.
Stochastic load modeling in the residential sector
Authors: Боровский А.В. , Юменчук А.А.
Published: August 2024

Спрос на электроэнергию в электрической сети меняется в зависимости от времени суток и потребностей потребителей. Реагирование на спрос – это изменение кривой потребительской нагрузки, сопровождающееся изменением цены на электроэнергию, в основном используемое поставщиками для ограничения пиков потребления. Уменьшение краткосрочного несоответствия между производством и потреблением помогает интегрировать в энергосистему возобновляемые источники электроэнергии, различные низкоуглеродные технологии, аккумуляторное хранение электроэнергии и электромобили. Одним из инструментов, используемых для сохранения баланса между производством и потреблением электроэнергии, являются умные счетчики, работающие в интеллектуальной сети. Подобные устройства широко распространены в США и странах Европейского союза, в том числе в жилом секторе. В Российской Федерации в настоящий момент внедрение интеллектуальных сетей в жилом секторе только начинается. В статье рассмотрена стохастическая модель потребления электроэнергии бытовыми приборами на основе теории сверток. Выполнен замер потребляемой мощности наиболее распространенными бытовыми приборами. Приведены несколько примеров составления профилей потребителей на основе полученных данных. Выявлены барьеры, возникающие при внедрении интеллектуальных систем энергоснабжения в Российской Федерации, а также причины, в связи с которыми растет заинтересованность поставщиков электроэнергии в интеллектуальных системах энергоснабжения.

The power demand on the electric grid varies depending on the time of day and the needs of consumers. Demand response is a change in the consumer load curve accompanied by a change of price, used primarily by suppliers to limit consumption peaks. Reducing the short-term mismatch between production and consumption helps to integrate renewable energy sources, various low-carbon technologies, battery storage of electricity and electric vehicles into the electric grid. One of the tools used to maintain a balance between electricity production and consumption is smart meters, which operating in asmart grid. Such devices are widespread in the United States and the European Union, in the residential sector too. At the moment, the introduction of smart grids in the residential sector is just beginning in the Russian Federation. The article considers a stochastic model of electricity consumption by household appliances, based on the convolution theory. The measurement of power consumption by the most common household appliances has been performed. Several examples of consumer profiling based on the obtained data are given.The barriers that arise during the implementation of smart grids in the Russian Federation are identified, as well as the reasons why the interest of electricity suppliers in smart grids is growing.
ENSURING RADIATION SAFETY DURING DECOMMISSIONING OF NUCLEAR RADIATION HAZARDOUS FACILITIES JSC “VNIINM”
Authors: Кузнецов А.Ю. , Bocharov K.G. , Хлебников С.В. , Верещагин И.И.
Published: August 2024

Рассматриваются вопросы организации и обеспечения безопасности при выводе из эксплуатации объектов использования атомной энергии ядерного топливного цикла, в том числе находящихся в черте плотной жилой застройки,в частности АО «ВНИИНМ». На примере уже завершенных работ по выводу из эксплуатации корпуса «Б» АО «ВНИИНМ» приводится описание успешной организации и осуществления обеспечения радиационной безопасности работ по выводу из эксплуатации радиоактивно загрязненного здания в черте плотной городской застройки города Москвы. Проанализированы мероприятия по обеспечению радиационного контроля при выводе из эксплуатации корпуса «Б». Показано, что радиационный контроль, проводимый в соответствии с проектной документацией по выводу из эксплуатации корпуса «Б», включал измерение радиационных характеристик демонтируемого оборудования и коммуникаций, строительных конструкций, удаляемых отходов. Проведено 339 039 измерений, что в 1,9 раза превысило запланированное в проектной документации количество. Описано применение средств индивидуальной защиты, позволивших наряду с соблюдением санитарно-пропускного режима полностью исключить попадание радиоактивных веществ на слизистые оболочки и кожные покровы персонала и обеспечить его нормативную дозовую нагрузку. Проведено сопоставление проектных и фактических показателей по выводу из эксплуатации корпуса «Б», проектных показателей вывода из эксплуатации установки У-5, корпуса «Ж» АО «ВНИИНМ».

The issues of organization and safety during decommissioning of nuclear power facilities of the nuclear fuel cycle,including those located in dense residential development, in particular JSC “VNIINM” are discussed. On the example of the already completed decommissioning of the building “B” of JSC “VNIINM”, a description of the successful organization and implementation of radiation safety of decommissioning of a radioactively contaminated building in the dense urban development of the city of Moscow is given. Measures to ensure radiation monitoring during the decommissioning of the building “B” are analyzed. It is shown that the radiation control carried out in accordance with the project documentation for decommissioning of the building “B” included the measurement of radiation characteristics of the dismantled equipment and communications, building structures, and disposed waste. 339 039 measurements were carried out, which is 1.9 times higher than the number planned in the project documentation. The article describes the use of personal protective equipment, which allowed, along with compliance with the sanitary and access control regime, to completely exclude the ingress of radioactive substances on the mucous membranes and skin of personnel, and to ensure the standard dose load of personnel. The comparison of design and actual indicators for decommissioning of the “B” building, design indicators for decommissioning of the U-5 installation, and the building “Zh” of the JSC “VNIINM” was made.
SELECTION OF OPTIMAL OPTION FOR RADIOACTIVE WASTE MANAGEMENT USING MATHEMATICAL METHODS
Authors: Бочкарёв В.В. , Бриллиантов Б.Д. , Крянев А.В.
Published: August 2024

Рассмотрены проблема выбора варианта обращения с радиоактивными отходами и применение методамногофакторного анализа при выборе оптимального варианта на множестве альтернатив. Приведенный метод позволяет решить сложную задачу по определению оптимального сценария обращения с радиоактивными отходами с помощью сравнения факторов, характеризующих возможные сценарии, для ранжирования их по важности и расчета комплексного показателя для каждого рассматриваемого варианта. Результатом применения данногометода является количественная оценка эффективности для каждого из рассматриваемых вариантов обращенияс радиоактивными отходами с максимальным значением комплексного показателя для выбора оптимального варианта.
DEVELOPMENT AND IMPLEMENTATION OF A SEISMIC MONITORING SYSTEM BASED ON THE SAFETY GUIDE “SEISMIC MONITORING OF AREAS SITING HAZARDOUS NUCLEAR OR RADIOLOGICAL FACILITIES” (RB-142-18)
Authors: Кишкина С.Б. , Бугаев Е.Г. , Лободенко И.Ю.
Published: August 2024

Раскрываются некоторые базовые принципы построения системы сейсмологического мониторинга, отраженные в руководстве по безопасности при использовании атомной энергии «Сейсмологический мониторинг участков размещения ядерно- и радиационно опасных объектов» (РБ-142-18). Основное внимание уделено необходимости регистрации и анализа слабых сейсмических событий, а также выбору систем мониторинга, способных такую регистрацию осуществить. Рассмотрены физические основы требований к выбору методики регистрации и к средствам измерений. Предложены методы оценки минимального порога чувствительности. Показано, что в условиях редких тектонических событий один из доступных принципов оценки работоспособности системы мониторинга – регистрация сейсмических сигналов от промышленных взрывов; приведены возможные способы определения природы источников таких сигналов. Решение задачи оценки возможного проявления сейсмических и геодинамических процессов на территории размещения ядерно- и радиационно опасных объектов не может быть полностью унифицировано. Такая задача должна решаться с достоверным научным обоснованием для каждого конкретного объекта с учетом его специфики. РБ-142-18 предоставляет алгоритм решения, опирающийся на мировой опыт ведения сейсмологических наблюдений, который может быть адаптирован для практически любых локальных условий.

The article reveals some basic principles of constructing a seismic monitoring system of sites for the location of nuclear and radiation hazardous objects, reflected in safety guide for the use of nuclear energy “Seismic Monitoring of Areas Siting Hazardous Nuclear or Radiological Facilities” (RB-142-18). The main intention is paid to the need to register small seismic events, as well as the choice of monitoring systems capable of such registration. The physical basis of the requirements for the choice of measurement methods and instruments is considered. In conditions of rare tectonic events, one way of the constructed system conformity assessment is the registration of quarry explosions signals; possible ways of their discrimination are described.The solution to the problem of assessing the possible manifestation of seismic and geodynamic processes in the territory of the location of nuclear and radiation hazardous objects cannot be completely unified. Such a task should be solved with reliable scientific justification for each specific object, taking into account its features. Safety Guide RB-142-18 provides a solution algorithm based on world experience in seismological monitoring, which can be adapted to any local conditions.
How good are current pocket based 3D generative models? : The benchmark set and evaluation on protein pocket based 3D molecular generative models
Authors: Liu Haoyang , Qin Yifei , Niu Zhangming , Xu Mingyuan , Wu Jiaqiang , Xiao Xianglu , Lei Jinping , Ran Ting , Chen Hongming
Published: August 2024

The development of three-dimensional (3D) molecular generative model based on protein pockets has recently attracted a lot of attentions. This type of model aims to achieve the simultaneous generation of molecular graph and 3D binding conformation under the constraint of protein binding. Various pocket based generative models have been proposed, however, currently there is a lack of systematic and objective evaluation metrics for these models. To address this issue, a comprehensive benchmark dataset, named as POKMOL-3D, is proposed to evaluate protein pocket based 3D molecular generative models. It includes 32 protein targets together with their known active compounds as a test set to evaluate the versatility of generation models to mimick the real-world scenario. Additionally, a series of 2D and 3D evaluation metrics was integrated to assess the quality of generated molecular structures and their binding conformations. It is expected that this work can enhance our comprehension of the effectiveness and weakness of current 3D generative models, and stimulate the discussion on challenges and useful guidance for developing next wave of molecular generative models.
Chemoproteomics-Enabled De Novo Discovery of Metallothionein Degraders Facilitates Probing Its Role in Cancer
Authors: Racioppo Brittney , Pechalrieu Dany , Abegg Daniel , Dwyer Brendan , Ramseier Neal , Hu Ying , Adibekian Alexander
Published: August 2024

Proteolysis targeting chimeras (PROTACs) represent powerful tools to modulate the activity of classically “undruggable” proteins, but their application has been limited to known ligands and a few select protein classes. Herein, we present our chemoproteomic strategy for de novo discovery of PROTAC degraders. Using comparative PROTAC versus ligand global proteomics analyses, we rapidly identify proteins selectively downregulated by “untargeted” PROTAC probes containing an E3 ligase recruiter and various cysteine-reactive protein-of-interest (POI) ligands. In this manuscript, we showcase our approach by identifying a first-in-class acrylamide- and VHL-based PROTAC for metallothionein 2A (MT2A) – a small, cysteine-rich, metal-binding protein implicated in heavy metal detoxification, zinc homeostasis, and cellular metastasis. Notably, isoform-specific MT overexpression has been shown to augment cellular migration and invasion across several cancer cell lines, though precise mechanisms are unknown due to insufficient tools to study MTs. We show that optimized PROTAC AA-BR-157 covalently binds conserved C44, degrades overexpressed MT2A with nanomolar potency, and reduces migration and invasion of triple negative breast cancer MDA-MB-231 cells. We further demonstrate a time-dependent increase in intracellular zinc levels following MT2A degradation as well as downregulation of protein diaphanous homolog 3 (DIAPH3), a positive regulator of actin and cell motility. Super-resolution imaging of MDA-MB-231 cells shows that downregulation of MT2A and DIAPH3 inhibits cell polarization and thereby migration, suggesting that MT2A regulates motility via DIAPH3-dependent cytoskeletal remodeling. In summary, our strategy enables the discovery of PROTACs for novel disease-related targets and lays the groundwork for expansion of the druggable proteome.
The development of a method to produce diagnostic reagents using LaNiO3 nanospheres and their application in nanozyme-linked immunosorbent assay
Authors: Nikitina Maria , Khramtsov Pavel , Devyatov Stepan , Valeev Rishat , Eremina Marina , Chukavin Andrey , Rayev Mikhail
Published: August 2024

Background: LaNiO3 perovskite nanoparticles, especially nanospheres (LNNS), show great promise in biomedical assays due to their peroxidase-like catalytic properties. Methods for synthesizing LaNiO3 nanoparticles of various shapes have been developed, with spherical and rod-shaped LaNiO3 showing better stability. However, LNNS-based diagnostic reagents have not been tested in nanozyme enzyme-linked immunosorbent assay (NLISA) or other enzyme-linked immunosorbent assays, and there is limited data on their synthesis. To fill this gap, it is necessary to develop a method for creating LNNS conjugates with monoclonal antibodies and to investigate the reproducibility, scalability, and applicability of these diagnostic reagents in NLISA. Results: We have successfully developed a method for producing novel diagnostic reagents utilizing LaNiO3 nanospheres. Our research demonstrates the application of these nanospheres in a NLISA specifically designed for the detection of C-reactive protein (CRP) in real serum samples. This method is both reproducible and scalable, allowing for the efficient production of nanospheres that are functionalized with monoclonal antibodies targeting CRP, with mean diameter of approximately 270 nm. Based on the promising results obtained from our experiments, we have developed and optimized a sandwich-format NLISA for CRP detection. This assay achieved lower limit of detection at 0.178 µg/L, with a dynamic range from 12.5 to 0.195 µg/L and a linear detection range extending from 0.195 to 6.25 µg/L, showcasing its potential for clinical applications. Significance and Novelty: The new NLISA method, utilizing LaNiO3 nanospheres in a sandwich format for the detection of CRP, significantly enhances sensitivity compared to similar use horseradish peroxidase-based -ELISA. In this study for the first time first the functionalization of lanthanum nickelate nanospheres with recognition elements have demonstrated. This advancement also sheds light on the technological challenges involved in synthesizing diagnostic reagents, identifying areas that need further exploration.