bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektivitas Kecerdasan Buatan VerasAI sebagai Referensi Desain Fasad Mahasiswa Arsitektur
Authors: Agi Nasrullah  , Muh Fais Giffari  , Taufik Hidayat. S  , Fanny Siti Rabania Achmad  , Muhammad Fiqri M. Muhlis
Published: December 2023

Digital era development has supported to lighten human work these days. There is a lot of software which is acted in that case. VerasAi is one of the software which support the architecture student to find ideas/reference facade to aplly in a design. Buildang facade has important role in aextethic and building termal performance, In order to an efficient and interesting facade design become crucial in architectural practice. Methode which is used in are kualitatif deduktif that describe plug-in VerasAI application and also sharing quisoner to the architectural students which has been following Studio architecture planning and using VerasAI as a rendering tools in a design process. As results of the research are to measure the efectiveness of using VerasAI in giving facade design concept ideas for architecture students. This research also disclose that VerasAI can help to increasing time effciency in facade design process, student can explore a lot of ideas quikly and effective is possible. However, there are also some constraint of using VerasAI such as algorithm limit and lack of control over some aspects of the design. In other hand, it show how are the advantage and lack of VerasAI and impact to the architecture student.
PERSPEKSTIF PROFESI GURU DALAM PENDIDIKAN INKLUSI ANAK BERBAKAT USIA DINI
Authors: Parwoto  , Faizal  , Usman
Published: December 2023

This article examines the teacher professional development model towards the paradigm of inclusive education for early childhood gifted children. The purpose of this paper is to provide an overview of the results of teacher professional development research carried out by the PPG Study Programme at each University Education Personnel Institute. Research subjects: kindergarten teachers; special school teachers; and lecturers. Data collection techniques were carried out with reference studies; questionnaires and interviews. Data were analysed with qualitative descriptive analysis. The results showed that 1) the inclusive education model for gifted children is feasible to be developed in Indonesia by preparing professional teachers in the field through special training. 2) Different approaches and curricula for gifted children in inclusive education settings; 3) A team of professionals and teachers as well as parents working collaboratively in solving problems of gifted children's existence and educational facilities; 4) The development of reciprocal reasonable attitudes in peers in social-emotional life is conditioned to form a good personality; 5) The acceleration and escalation programme of the early childhood gifted learning system is carried out based on Developpentally Appropriate Practice (DAP). and 6) The Teacher Professional Education (PPG) study program as a forum for assessment and research for the implementation of inclusive education for gifted children effectively.
Integrin-linked Kinase: It's Role in the Vascular System
Authors:   National Research Laboratory for Cardiac Stem Cell, Seoul National University College of Medicine, Seoul, Korea, Kim Hyo-Soo , Lee Seung-Pyo , Youn Seock-Won
Published: December 2023

Integrin-linked kinase (ILK) is an intracellular molecule that binds to the cytoplasmic domain of β1 and β3-integrin. It has been previously demonstrated in various epithelial cell lines to mediate the 'outside-in' signals into the cells and to control the survival of these cells by controlling the phosphorylation of various downstream proteins, such as protein kinase B/Akt (PKB/Akt). We now present in this review the important role of ILK in the vascular system with particular emphasis on its role in endothelial cells (ECs). The results presented here demonstrate that ILK is essential for the proper function, structure and survival of ECs and finally, for the process of neovascularization.
Kinetic Determination of Acarbose and Miglitol in Bulk and Pharmaceutical Formulations Using Alkaline Potassium Permanganate
Authors:   Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, 35516, Mansoura, Egypt, Tolba M. M. , Ibrahim F. A. , Ali F. A. , Ahmed S. M.
Published: December 2023

A simple and sensitive kinetic spectrophotometric method was established for the determination of acar-bose and miglitol in bulk and in their pharmaceutical preparations using alkaline potassium permanganate as an oxidizing agent. the method involves determination of acarbose and miglitol by kinetic studies of their oxidation at room temperature for a fixed time of 15 minutes for acarbose and 25 minutes for miglitol. The absorbance of the colored manganate ion was measured at 610 nm. Alternatively, the kinetic decrease in the absorbance of permanganate upon addition of the studied drugs at 525 nm was also used. The absorbance¬concentration plot was rectilinear over the concentration range of 4 - 20 and 1-10 µg/ ml for acarbose and miglitol, respectively. The detection limits were 0.189 and 0.089 µg/ ml at 610 nm and 0.081 and 0.179 µg/ ml at 525 nm for acarbose and miglitol respectively. The method was successfully applied for the determination of these drugs in their dosage forms. the results obtained were in good agreement with those obtained with the reference methods.
Panretinal-Photocoagulation before Pars Plana Vitrectomy Influences Vitreous Level of Interleukin-6 but not of Vascular Endothelial Growth Factor in Patients with Diabetic Retinopathy
Authors:   Department of Ophthalmology, NTT East Japan Tohoku Hospital, Miyagi, Japan, Shimura Masahiko , Yasuda Kanako , Nakazawa Toru , Nishida Kohji ,   Department of Ophthalmology and Medi cal Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan, Shiono Takashi ,   Shiono Eye Center, Sendai, Japan
Published: December 2023

For eyes with diabetic retinopathy which require vitreous surgery and pan-retinal photocoagulation (PrP), pre-treatment of PrP before vitreous surgery reduce the activity of diabetic retinopathy, however sometimes cause macular edema leading to visual disturbance. some cytokines in the vitreous increase in eyes with diabetic macular edema, thus the relationship between PrP and vitreous cytokines is to be inves-tigated. In this study, 72 eligible eyes of 65 patients were recruited, and 36 eyes had pre-treatment of PrP before vitreous surgery. the other 36 eyes were served as control which had PrP not before but under sur-gery. There was no statistical significant difference of systemic conditions between two groups. All eyes had pars plana vitrectomy, and 1 ml of vitreous sample was obtained under the surgery. Vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in the vitreous sample were measured in each case. After the completion of pre-treatment of PRP, macular edema defined as increase of foveal thickness was prominently worsened, and the vitreous level of IL-6 in PrP pre-treated group showed statistically higher than that in control. In contrast, there was no significant difference of VEGF level between two groups. While, vitreous level of VEGF in control group was strongly correlated with grade of retinopathy and duration of diabetes. In conclusion, PRP influenced vitreous level of IL-6 but not VEGF, leading to macular edema, which sug-gests that IL-6 plays critical roles of PrP induced macular edema.
Urotensin-II Immunoreactivity in Normolipidemic and Hyperlipidemic New Zealand White Rabbits Following Balloon Angioplasty and Stenting
Authors:   Division of Cardiology, Montreal General Hospital, McGill University Health Center, Montreal, Quebec, Canada, Giaid Adel , Bousette Nicolas , Chouiali Fazila ,   Division of Cardiology, Montreal General Hospital, McGill University Health Center, Montreal, Quebec, Canada, Ohlstein Eliot H. , Douglas Stephen A. ,   The Cardiovascular and Urogenital-CEDD, GlaxoSmithKline, King of Prussia, PA, USA
Published: December 2023

Treatment for symptomatic atherosclerosis is being carried out by balloon mediated angioplasty, with or without stent implantation, more and more frequently. Although advances with the development of drug eluting stents have improved prognosis, restenosis is still the most limiting factor for this treatment modality. Urotensin-II (UII), a small pleiotropic vasoactive peptide is increasingly being recognized as a contributory factor in cardiovascular diseases. We qualitatively evaluated UII immunoreactivity (Ir) in three models of balloon angioplasty mediated restenosis. Specifically, we performed balloon angioplasty in the ilio-femoral arteries of New Zealand White rabbits (NZWr) fed either a normal chow or high fat diet. In addition, UII-Ir was also assessed in stent implanted abdominal aortae of NZWr fed a high fat diet. UII was constitutively expressed in the endothelium of all arterial segments evaluated. Abundant expression of UII was associated with lesion progression, particularly in myointimal cells, and less so in medial smooth muscle cells (sMc). the strongest UII-Ir was observed in foam cells of animals fed a high fat diet. We demonstrate abundant expression of UII in regenerating endothelial cells and myointimal cells in vascular lesions following balloon mediated angioplasty and stent implantation in both animals fed a normal chow and high fat diet.
Dual Role of CXCL10 as Conductor of Cellular Trafficking during Type 1 Diabetes
Authors:   Pharmazentrum Frankfurt / Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES), Johann Wolfgang Goethe University, Frankfurt am Main, Germany, Christen Urs , Hintermann Edith
Published: December 2023

One possible way of how autoimmune disease can be initiated is by infection with a foreign pathogen. Especially viruses are thought to act as triggering factors, inducing a detrimental attack against 'self' by the immune system of a susceptible host because of two major reasons. First, viruses cause a massive inflammation of the infected tissue and therefore initiate the infiltration of a broad variety of leukocytes, including potentially 'self'-reactive lymphocytes. Second, some viruses have been demonstrated to bear molecules with a strong structural similarity to host components. The existence of such a 'molecular mimicry' may elicit an immune response, which is initially generated in defense against the invading pathogen but in a second wave targets similar structures of the host. In the present review we will reflect on the dual role of inflammatory factors during this process and discuss possibilities of how such a detrimental second wave of the immune system can be blocked. Most of the presented data have been obtained from animal models that integrate the concept of molecular mimicry. They use transgenic mice expressing a defined model protein specifically in a target tissue and a virus containing either an identical or a similar protein as a triggering factor.
Sildenafil Inhibits the Proliferation of Cultured Human Endothelial Cells
Authors:   Department of Cardiology and Angiology, Justus-Liebig University of Giessen, Erdogan Ali , Kuhlmann Christoph Ruediger Wolfram ,   Institutes of Physiology and Pathophysiology, Johannes Gutenberg-University of Mainz, Luedders Doerte Wiebke , Muenz Benedikt Manuel , Schaefer Christian Alexander , Tillmanns Harald , Wiecha Johannes ,   Department of Cardiology and Angiology, Justus-Liebig University of Giessen
Published: December 2023

The proliferation of endothelial cells plays a crucial role in the development of intraplaque angiogenesis (IPA). IPA is a major source of intraplaque hemorrhage and therefore contributes to the destabilization of atherosclerotic plaques. Therefore, the aim of the present study was to examine, whether sildenafil inhibits endothelial cell growth. The proliferation of human endothelial cells derived from umbilical cord veins (HUVEC) was examined on DNA level by measurements of (3H)-thymidine incorporation. Cell viability was analyzed using trypan blue staining. The proliferation of cultured human endothelial cells was significantly decreased by 1 μmol/l (-48.4%) and 10 μmol/l (-89.6%) sildenafil (n=10, p<0.05). This was not a cytotoxic effect, because cell viability was only reduced at sildenafil concentrations of 50 μmol/l or greater. In addition sildenafil significantly reduced endothelial proliferation induced by bFGF (n=10, p<0.05). The presented results demonstrate an antiangiogenic effect of sildenafil that might be useful in the prevention of atherosclerotic plaque vascularization.
EMRSA-15 Bacteremia is not Associated with a Worse Outcome Compared with Bacteremia Caused by Multidrug-Resistant MRSA
Authors:   Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Hsu Li-Yang , Loomba-Chlebicka Nidhi , Koh Tse-Hsien , Kang Mei-Ling , Tan Ban-Hock ,   Singapore General Hospital, Singapore, Tambyah Paul Ananth ,   Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Published: December 2023

EMRS A-15 (ST 22-MRS A-IV) is rapidly replacing the endemic ST 239 health care-associated methicillin- resistant Staphylococcus aureus clone in Singapore. A one-year single-centre cohort study of inpatients with MRS A bacteremia was performed to determine if bacteremia caused by EMRS A-15 was associated with worse outcomes compared to bacteremia caused by the endemic ST239 strain. Strains were identified by antibiotypes, and subsequent validation was performed on a selected sample of MRS A strains via pulsedfield gel electrophoresis and staphylococcal chromosome cassette mec typing. Two hundred and twenty-eight patients with MRS A bacteremia were studied; Seventy-three were infected with EMRS A-15. EMRS A-15- and ST 239-infected patients were similar regarding gender, frequencies of most co-morbidities, and risk factors for adverse outcomes. Similar numbers of EMRS A-15-infected and ST 239-infected patients died (24.7% vs 27.1%, P=0.70) or developed complicated infections (41.1% vs 40.0%, P=0.88). After multivariate analysis, EMRSA-15 as a cause of bacteremia was not significantly associated with either death or development of complicated infections, although inappropriate therapy (5.45-fold, P<0.01) and a respiratory source of bacteremia (4.69, P<0.01) were independently associated with subsequent mortality. The increased propensity of EMRS A-15 for dissemination was not associated with increased virulence in our patients. Further work in determining the mechanisms by which highly transmissible MRS A spreads rapidly is required to better target infection control approaches at these important emerging MRS A clones.
Suramin Increased Telomerase Activity in the C6 Glioma/ Wistar Experimental Brain Tumor Model
Authors:   Department of Biochemistry, Istanbul University, Faculty of Pharmacy, 34116 Beyazit, Istanbul-Turkey, Erguven Mine , Bilir Ayhan , Aktar Fadime ,   Department of Histology and Embryology, Istanbul University, Faculty of Medicine, 34093 Capa, Istanbul-Turkey, Altug Tuncay ,   Animal Breeding and Research Center, Istanbul University, Cerrahpasa Faculty of Medicine, 34098 Cerrahpasa, Istanbul-Turkey, Akev Nuriye ,   Department of Biochemistry, Istanbul University, Faculty of Pharmacy, 34116 Beyazit, Istanbul-Turkey
Published: December 2023

Glioblastoma multiforme (GBM) is the most treatment-resistant glioma variant. Significant roles for telomerase in etiology, recurrence and drug resistance of GBM have been highlighted. Suramin (Bayer, Leverkusen, Germany) is an antineoplastic agent that affects many cellular mechanisms including growth factor, purinergic receptor, cytokine and key cellular enzymes signaling. The aim of this study was to investigate whether suramin, 40 mg/kg, i.p., inhibits telomerase activity in a subcutaneous C6 glioma/Wistar experimental brain tumor model using PCR based telomeric repeat amplification assay. In comparison to the control group, suramin increased tumor volume and telomerase activity. We also used transmission electron microscopy to evaluate the alterations of cell morphology. Apoptosis was seen markedly in electron micrographs of the control group and anti-apoptotic activity of telomerase was verified in the electron micrographs of suramin-applied group. The in vitro inhibitory effects of suramin on telomerase activity in several cell lines --except for brain tumors-- have been reported. Contrary to in vitro reports, our results were the first to demonstrate that suramin increased telomerase activity in a C6 glioma/Wistar experimental brain tumor. Large numbers of drugs exhibited apparent hormetic effects on cultured cancer cells and in vivo cancer growth. Several drug examples for their hormetic effects in vivo were listed as resveratrol, suramin, and tamoxifen. The action of suramin in the present study could be evaluated as one of the hormetic examples of suramin in vivo.
Sensitive Assay for Carvedilol in Tablets and Spiked Human Plasma Using a Flow-Injection Chemiluminometric Method
Authors:   Department of Pharmaceutical Chemistry, College of Pharmacy, Women Student- Medical Studies and Sciences Sections, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia, Sultan Maha A. , Arfaj Nawal Al ,   Department of Chemistry, College of Science, Women Student-Medical Studies and Sciences Sections, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia, Abdine Heba H. ,   Department of Pharmaceutical Chemistry, College of Pharmacy, Women Student- Medical Studies and Sciences Sections, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia
Published: December 2023

A simple and sensitive chemiluminometric method using flow injection (FI) is developed for the determination of carvedilol, based on the reaction of carvedilol with tris (2, 2'-bipyridyl) ruthenium (II), and KMnO4 in sulfuric acid medium. Under the optimum conditions; the chemiluminescence (CL) intensity is a linear function of carvedilol concentration over the range of 0.04–1.0 μg ml-1 (9.8 × 10-8 - 2.5 × 10-6 mol L-1) with a detection limit (S/N=3) of 0.025 μgml-1 (6.2 × 10-8 mol L-1). The relative standard deviation of the proposed method calculated from 10 replicate injections of 0.4 μg ml-1 carvedilol is 0.95%. The sample throughput is 90 samples h-1. The method is applied successfully to the determination of carvedilol in tablets dosage form and spiked human plasma.
Biological and molecular properties of Dengue 2 strains Isolated during the DHF/DSS Cuban epidemic, 1981
Authors:   Department of Virology, PAHO/WHO Collaborating Centre for the Study of Dengue and its Vector, Institute of Tropical Medicine ", Guzman Maria G. ,   Pedro Kouri",   , Havana City, Cuba, Gonzalez Lester , Alvarez Mayling , del Rosario Delfina , Pavon Alequis , Prado Irina , Diaz Joel , Morier Luis
Published: December 2023

To study some biological and molecular properties of nine DENV-2 strains isolated during the 1981 Cuban epidemic, temperature sensitivity, viral plaque size, the kinetic of virus replication in newborn mice inoculated by intracerebral route, the influence of pH medium on virus-cell attachment phase and the restriction enzyme pattern were studied. Strains were classified in two patterns according to temperature sensitivity, plaque size, virus replication in mouse brain and cell culture and restriction enzymatic pattern The changes observed differentiate clearly the strains isolated at the beginning and at the end of the epidemic suggesting that viruses with different characteristics circulated.
Heterogeneity of 3'-Untraslated Region of Genome RNA of the Tick-Borne Encephalitis Virus (TBEV) Strains Isolated from Ticks in the Western Siberia, Russia
Authors:   Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia, Morozova Olga V. , Morozov Igor V. ,   Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia, Bakhvalova Valentina N. ,   Institute of Systematics and Ecology of Animals of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Published: December 2023

The tick-borne encephalitis virus (TBEV) strains have been isolated from unfed adult ticks Ixodes persulcatus Schulze in Novosibirsk region (South-Western Siberia, Russia) beginning from 1980 till 2006. The TBEV 3'-untraslated region (3'UTR) variable fragment was amplified with primers corresponding to conservative flanking areas. The RT-PCR product lengths varied in range from 100 to 400 bp. Comparative analysis of 3’UTR nucleotide sequences revealed a few groups of the TBEV strains within Siberian genetic subtype with significant intra-group homology and essential differences between groups. Correlation between lengths of the 3’UTR fragments and hemagglutination (HA) titers for subsequent passages of the TBEV strains was not found. However, for the viral strains with shorter 3'UTR (less than 200 nucleotides) incubation period for suckling mice was longer than 5 days. It might be resulted from decreased RNA synthesis or reduced neuroinvasiveness.
Photodynamic Therapy of the Murine LM3 Tumor Using Meso-tetra (4-N,N,N-trimethylanilinium) Porphine
Authors:   Department of Biology, Faculty of Sciences, Autonomous University of Madrid, and Center for Biological Research, High Council for Scientific Research, Madrid, Spain, Stockert Juan C. , Colombo L.L. ,   Institute of Oncology “A.H. Roffo”, University of Buenos Aires, Argentina, Juarranz A. ,   Department of Biology, Faculty of Sciences, Autonomous University of Madrid, Spain, Canete M. ,   Department of Biology, Faculty of Sciences, Autonomous University of Madrid, Spain, Villanueva A. ,   Department of Biology, Faculty of Sciences, Autonomous University of Madrid, Spain
Published: December 2023

Photodynamic therapy (PDT) of cancer is based on cytotoxicity induced by a photosensitizer in the presence of oxygen and visible light, resulting in cell death and tumor regression. This work describes the response of the murine LM3 tumor to PDT using meso-tetra (4-N,N,N-trimethylanilinium) porphine (TMAP). BALB/c mice with intradermal LM3 tumors were subjected to intravenous injection of TMAP (4 mg/kg) followed 24 h later by blue-red light irradiation (lmax: 419, 457, 650 nm) for 60 min (total dose: 290 J/cm2) on depilated and glycerol-covered skin over the tumor of anesthetized animals. Control (drug alone, light alone) and PDT treatments (drug + light) were performed once and repeated 48 h later. No significant differences were found between untreated tumors and tumors only treated with TMAP or light. PDT-treated tumors showed almost total but transitory tumor regression (from 3 mm to less than 1 mm) in 8/9 animals, whereas no regression was found in 1/9. PDT response was heterogeneous and each tumor showed different regression and growth delay. The survival of PDT-treated animals was significantly higher than that of TMAP and light controls, showing a lower number of lung metastasis but increased tumor-draining lymph node metastasis. Repeated treatment and reduction of tissue light scattering by glycerol could be useful approaches in studies on PDT of cancer.
Quality Assurance and Commissioning of an Infrared Marker-based Patient Positioning System for Frameless Extracranial Stereotactic Radiotherapy
Authors:   Department of Radiation Oncology, Advanced Centre for Treatment Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Gupta Tejpal , Phurailatpam Ms Reena , Ajay Mishra , Rajeshri Pai ,   Department of Radiation Oncology, Advanced Centre for Treatment Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, Pranshu Mohindra , Supriya Chopra ,   Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India18, 07743 Jena
Published: December 2023

Rapid advancements in imaging technology have led to remarkable improvements in identification and localization of tumors, ushering the era of high-precision techniques in contemporary radiotherapy practice. However, uncertainties in patient set-up and organ motion during a course of fractionated radiotherapy can compromise precision of radiation therapy. Excellent accuracy has been achieved with invasive and non-invasive fixation systems for stereotactic radiotherapy. This report describes the commissioning procedure and Quality Assurance studies done to evaluate the accuracy of isocenter localization by an infrared marker-based positioning system (ExacTrac). The ExacTrac has two infrared cameras that emit and detect infrared rays from reflective markers and construct three-dimensional coordinates of each marker. It detects the difference of the actual isocenter position from the planned isocenter coordinates in three translational (lateral, longitudinal, vertical, or x,y,z axes) and three rotational axes (six degree of freedom). This study performed on a flat and static phantom shows excellent accuracy achieved by the ExacTrac system. The positioning accuracy of ExacTrac (±1 mm translational displacement and ±1 rotational errors) can be a valuable tool in implementing frameless extracranial stereotactic radiotherapy. Nevertheless, it needs to be further evaluated on patients with inherent motion and greater positional uncertainty before being adopted in clinical practice.
العلامة عبد الله بن أحمد بامخرمة وفتاويه: كتاب المعاملات، مسائل الوكالة ( دراسة وتحقيق ).
Authors: الجريري رامي صالح نصيب
Published: December 2023

تهدف هذا الدراسة إلى التعريف بالقاضي عبدالله بن أحمد بامخرمة، وإلى بيان فتاويه في باب الوكالة، كما حاولت هذه الدراسة عرض جانب من التراث الفقهي الذي خلَّفته المدرسة الحضرمية الفقهية الشافعية، وما شخص العلامة عبد الله بن أحمد بامخرمة إلا نموذج تمثيلي ودليل عملي على النضج العلمي والتميُّز المنهجي لرجالات المدرسة الحضرمية الشافعية، فالعلامة بامخرمة من مشاهير علماء حضرموت البارزين الذين ظلت وستظل آثارهم العلمية شاهدةً على نبوغهم، كما جاءت الدراسة لإبراز علماء المسلمين عمومًا وعلماء اليمن على وجه الخصوص، والتعريف بهم وبجهدهم العلمي في خدمًة الفقه الإسلامي، وهذه الفتاوى مملوءة بالمسائل الفقهية المتنوعة والفوائد المختلفة، والتي يحتاجها كل طالب علم.
      وقد خلصت الدراسة إلى مجموعة من النتائج أبرزها:  _إن الإفتاء منصب عظيم خطير، لا يجوز لأحد أن يتولاه إلا إن تأهَّل له، بأن يكون واسع العلم متبحراً، وهذا ما رأيناه في شخصية العلامة عبدالله بن أحمد بامخرمة.
  _ ما قرره العلامة بامخرمة في أجوبته على مسائل الوكالة لا يخرج - في الأغلب- عن المعتمد عند فقهاء الشافعية. وأوصت الدراسة بمجموعة من التوصيات أبرزها:
 _ ينبغي للدول والحكَّام والمسؤولين إسناد الفتوى لمن هو أهل لها من أهل العلم، وتشكيل دور أو مجالس للإفتاء؛ حتى لا يترك الإفتاء لمن ليس أهلاً له.
 _ضرورة الاهتمام بتحقيق المخطوطات؛ لإحياء التراث الإسلامي القديم والاستفادة مما خطه أجدادنا القدماء في كافة التخصصات.
فاعلية برنامج قائم على استراتيجية القصة في تنمية مهارات الاستماع لدى تلاميذ الصف الخامس من التعليم الأساسي في الجمهورية اليمنية.
Authors: عبده سماح عبد الوهاب علي , السبع سعاد سالم
Published: December 2023

هدف البحث إلى الكشف عن فاعلية برنامج قائم على استراتيجية القصة في تنمية مهارات الاستماع لدى تلاميذ الصف الخامس من التعليم الأساسي في الجمهورية اليمنية، واتبع البحث المنهج شبه التجريبي، واقتصرت عينة البحث على (95) تلميذة من تلميذات الصف الخامس الأساسي، وقُسمت العينة بطريقة عشوائية إلى مجموعتين متكافئتين (تجريبية وضابطة)، بلغ عدد المجموعة التجريبية (47) تلميذة، والضابطة (48) تلميذة، ولتحقيق هدف البحث أعدت الباحثتان قائمة بمهارات الاستماع وبرنامجًا قائمًا على استراتيجية القصة، يتضمن دليلا للمعلم وكتابًا للتلميذ، واختبارًا في مهارات الاستماع، وتوصل البحث إلى مجموعة من النتائج أهمها: وجود فروق ذات دلالة إحصائية عند مستوى دلالة (0.05) بين متوسطات درجات تلميذات المجموعتين (التجريبية والضابطة) في اختبار مهارات الاستماع البعدي لصالح المجموعة التجريبية، ووجود فروق ذات دلالة إحصائية عند مستوى دلالة (0.05) بين متوسطات درجات تلميذات المجموعة التجريبية في التطبيقين (القبلي والبعدي) لاختبار مهارات الاستماع لصالح التطبيق البعدي، وكان من أبرز توصيات البحث: توظيف استراتيجية القصة في تنمية مهارات اللغة العربية، وتخصيص منهاج للاستماع لجميع الصفوف الدراسية، وتحديد مهارات الاستماع الخاصة بكل صف دراسي لتدريس الاستماع بوصفه المهارة اللغوية الأولى التي يقوم عليها تَعلم المهارات اللغوية الأخرى.
المسؤولية الجنائية عن جرائم الاتجار بالبشر في القانون دراسة مقارنة بالفقه الإسلامي
Authors: الوريث محمد شرف أحمد
Published: December 2023

أصبحت جريمة الاتجار بالبشر بمختلف صورها وأشكالها موضوعاً خصباً وثرياً، كونها تنتهك بصورة أساسية حقوق الإنسان وكرامته وحريته، وعلى رأسها حقه في أن يكون متحرراً من كافة أشكال سوء المعاملة والاستغلال، وتتسم بأنها جرائم واقعة على الإنسان ذلك أن محل هذه الجرائم وموضوعها هو الإنسان نفسه، وهي ليست مقصورة على جنس معين أو سن معين، بل تشمل الأطفال والنساء والرجال وتمتد إلى جميع الفئات البشرية وتشمل جميع الفئات العمرية، فهي جريمة تمس حياة الأفراد والمجتمعات عموماً وتؤدي إلى الانهيار الاجتماعي والاقتصادي والثقافي لدى مختلف الشعوب، ومما زاد في تعقيدها تطور صورها ووسائل ارتكابها بين الحين والآخر، خاصةً وان هناك الآلاف من الرجال والنساء والأطفال الذين دفعتهم ظروفهم الاجتماعية أو نتيجة للكوارث الطبيعية والحروب والأزمات الاقتصادية والظروف المعيشية الصعبة إلى أن يكونوا فريسة سهله للوقوع في عمليات الاتجار بالبشر من قبل العصابات الإجرامية التي تتكون من أشخاص طبيعيين أو أشخاص اعتبارية منظمة تتولى غالباً الإشراف على تنظيمها ومراقبة تنفيذ عملياتها المختلفة، التي تتمثل  في تجنيد الضحايا ونقلهم واستلامهم وتسليمهم واستقبالهم وإيواؤهم بصورة مشروعة أو غير مشروعة داخل حدود الدولة نفسها أو عبر حدودها الوطنية إلى دولة أخرى، بغرض استغلال الضحايا في أعمال السخرة والخدمة القسرية أو أعمال الدعارة وسائر صور الاستغلال الجنسي أو نزع الأعضاء البشرية والمتاجرة بها وغيرها من صور الاستغلال بغرض تحقيق أرباح ومنافع مادية أو معنوية، ويستوي في ذلك أن يكون استغلال الضحية طواعية باستخدام وسائل الاحتيال والتغرير أو قسراً عن طريق الإكراه باستعمال القوة أو التهديد بها أو الاختطاف وغيرها من الوسائل، الأمر الذي يستدعي تحديد المسؤول عن هذه الجرائم خصوصا حين يتعدد القائمون عليها والمساهمون في ارتكابها داخل إقليم الدولة أو خارجها، وأيضا تقرير مسؤولية كل من له علاقة بارتكاب هذه الجرائم من فاعل أصلي أو مساهم سواء أكان شخصاً طبيعياً أو  شخصية اعتبارية، لذلك كان علينا كباحثين أن نتطرق لهذه الجريمة ونبين ماهيتها وتحديد مسؤولية مرتكبيها وصولاً إلى المساهمة في إيجاد الحلول والمعالجات المناسبة للتصدي لهذه الجرائم والحد من انتشارها وتوسعها,
آيات الأحكام في سورة الرعد من تفسير العهد الأكيد، للإمام الحسن بن علي المؤيدي (ت:1026هـ)
Authors: العلفي خديجة عبدالله محمد
Published: December 2023

يهدف البحث إلى التعريف بصاحب المخطوط وحياته، والتعريف بالمخطوط، والإسهام في جعل المخطوط كتابًا في متناول يد القارئ، وإضافة مصدرًا من مصادر التفسير للمكتبة الإسلامية.
المنهج المتبع في البحث هو: المنهج الوصفي والتاريخي والاستقرائي، وينقسم إلى : مقدمة، ومبحثين، وخاتمة، وفهرست، اشتملت المقدمة على: أسباب اختيار المخطوط للتحقيق، وأهميّة المخطوط، وأهداف تحقيق المخطوط، والدراسات السابقة، ومنهج البحث، وتقسيمات البحث، كما اشتمل المبحث الأوّل على: الدراسة النظرية، وفيها مطلبان: المطلب الأوّل: ترجمة مؤَلِفي كتابي: (البيان والتجريد)، والتعريف بكتابهما، المطلب الثاني: ترجمة مؤلف مخطوط (العهد الأكيد)، والتعريف بمخطوطه، والمبحث الثاني وفيه: تفسير آيات الأحكام في سورة الرعد، وخُتِم هذا البحث بمجموعة من النتائج كان من أهمها :

إن الإمام الحسن المؤيدي كان مؤثرًا في الحياة العلمية والثقافية والسياسية في عصره من خلال دعوته لنفسه، ومن خلال المؤلفات التي ألفها.
تبين أن مخطوط (العهد الأكيد تفسير القرآن المجيد) غزيرٌ في مادته العلمية؛ حيثُ جمع فيه مؤلفه أمورًا كثيرة، منها ما يتعلق بعلوم القرآن، والقراءات القرآنية، واللغة، مستشهدًا بأحاديث نبوية، مناقشًا للقضايا الفقهية، مهتمًا باللغة واشتقاقات ألفاظها، وغيرها من العلوم الأخرى، فكان جامعًا لآراء وأقوال كثيرة في التفسير من غير إطالة في شرحها، أو إخلال بالاختصار.
إنصاف الإمام الحسن المؤيدي في ترجيحه بين الأقوال فيرجَّح القول بما يقضيه الحال والدليل، وإن لم يكن قول المذهب الزيدي، وهذا يدل على انصافه وعدم تعصبه.

وأخيرًا، ذيَّل هذا البحث بقائمة فهرس المصادر والمراجع مرتبة أبجديًّا.
مستوى اللياقة العضلية الهيكلية لتلميذات مرحلة التعليم الأساسي بأمانة العاصمة صنعاء- للفئة العمرية (10-12) سنة
Authors: الورافي إبراهيم علي , الزبيري سارة سعيد
Published: December 2023

هدفت الدراسة الحالية إلى التعرف على مستوى اللياقة العضلية الهيكلية لتلميذات مرحلة التعليم الأساسي بأمانة العاصمة صنعاء للفئة العمرية (10 – 12 )سنة ، كما هدفت إلى التحقق من وجود فروق في مستوى اللياقة  العضلية التي تعزى إلى متغير الفئة العمرية، وقد استخدم الباحثان المنهج الوصفي، وتكوّنت عينة الدراسة من 530 طالبة  تم اختيارها بالطريقة العشوائية، واستخدم الباحثان الاختبارات والمقاييس بوصفها أداة لجمع البيانات،  وكذلك الأساليب الإحصائية  التالية المتوسطات الحسابية والانحرافات  المعيارية ومعامل ارتباط بيرسون واختبار توكي لمعرفة دلالة الفروق. وتوصلت الدراسة الحالية إلى أن مستوى اللياقة العضلية الهيكلية المتمثلة في اختبار المرونة ثني الجذع إلى الأمام من الجلوس طولاً، واختبار التحمل العضلي(الجلوس من الرقود مع ثني الركبتين) منخفض في حين أن مستوى القوة العضلية (الوثب العريض من الثبات) جاء في المستوى الآمن صحياً. وتوصي الدراسة بضرورة اهتمام المعلمين بالتربية الرياضية، وذلك بتنمية عناصر اللياقة البدنية وخاصة المرتبطة بالصحة في درس التربية الرياضية بجانب تنمية الجانب المهاري.
‘Warming up’ to populist leaders: A comparative analysis of Argentina and Spain
Authors: Carty Emily , Torcal Mariano
Published: December 2023

What makes populist leaders, responsible for many episodes of democratic backsliding, especially appealing to a significant part of the electorate? In the following pages we argue that the effect of perceptions regarding leaders’ ‘warmth’ causes them to be perceived as having good intentions toward and even being part of ‘the people,’ resulting in a more positive overall evaluation among citizens with more critical views of democratic representativeness (external political efficacy). We test this hypothesis in two very different political systems, Argentina and Spain, using data from original surveys that contain batteries of questions on warmth and competence trait dimensions for multiple leaders in both countries. The results show that while perceptions of traits along both warmth and competence dimensions are important for the evaluation of all leaders in democratic systems, the interactive effect between external political efficacy and perceptions of warmth is important for explaining more positive evaluations of populist leaders.
Colonial mechanisms for repudiating indigenous sovereignties in Australia: A Foucauldian-genealogical exploration of Australia day
Authors: Lipscombe Tamara , Hendrick Antonia , Dzidic Peta , Bishop Brian , Garvey Darren
Published: December 2023

A Foucauldian genealogical approach was used to explore the historical context surrounding Australia Day social tensions. Historic Indigenous-settler relations appear central to Australia Day events. Australia Day social contestation suggests unsettlement surrounding the ways in which Australian nationhood is predicated on colonial-settler privilege and exploitation of Aboriginal and Torres Strait Islander sovereignties. While modalities of colonial-settler power are identified, so too are Indigenous forms of resistance that serve to disrupt settler privileges. The findings indicate that settler determination of Australia Day acts to preserve settler sovereignty within the national mythscape as a mechanism in the colonial project and repudiation of Indigenous sovereignties in Australia. However, Indigenous forms of resistance challenge settler constructions of the Australian mythscape and nationhood.
A comparison of methods for specifying optimal random effects structures
Authors: Luo Wen , Li Haoran
Published: December 2023

Using Monte Carlo simulations, this study compared the performance of various approaches to the specification of random effects structures in linear mixed effects models (LMMs), including the minimal approach, the maximal approach, the forward search, the backward search, and the all-possible structures approach. The results showed that if the predictor of interest is at the within-cluster level or involves a cross-level interaction, the maximal approach, the best-path forward search, and the best-path backward search are all desirable methods. If the predictor of interest is at the cluster level, it is not essential to specify random slopes of Level-1 predictors. In addition, it is important to specify random slopes of within-cluster control variables, as they can increase the statistical power for testing the main within-cluster variables, especially when the sample size is small and the variance of the random slope of the control variable is large.
Diversity and molecular identification of endosymbionts of the white-flies Bemisia tabaci and Trialeurodes vaporariorum
Authors: Kareem Ali A. , Al-Zurfi Sienaa , Lahuf Adnan A. , AL-Abedy Aqeel N. , Abd Kamel Lubna , Port Gordon , Wolff Kirsten
Published: December 2023

The infection of insects with symbiotic bacteria has significant implications for the evolution and ecology of the hosts. Maternally inherited symbionts associated with B. tabaci and T. vaporariorum whiteflies play a vital role in their fitness and survival. Whitefly symbionts have been identified in many countries, but no study has been undertaken in Iraq and the UK. For the first time in both countries, the molecular identification and diversity of the symbionts of both whiteflies have been investigated in the present study. Fourteen populations of B. tabaci from Iraq and twenty populations of T. vaporariorum from the UK were used to detect and identify seven common endosymbiont bacteria associated with whitefly using the 16S rRNA and 23S rRNA nuclear markers. All females and males of B. tabaci harboured one primary symbiont, Portiera aleyrodidarum, and almost all of both sexes of all B. tabaci species have the two secondary symbionts Hamiltonella sp. and Rickettsia sp. The primary symbiont P. aleyrodidarum was also detected in both sexes of T. vaporariorum, whereas only one secondary symbiont, Arsenophonus sp., was detected in almost all females but not in the males. Additionally, an investigation into genetic diversity using three genes of the Arsenophonus sp. populations showed no variation among different populations. The results supported the notion that Arsenophonus sp. might play an important role in the survival of T. vaporariorum females and maybe a killer of male whiteflies. Also, secondary symbionts Hamiltonella sp. and Rickettsia sp. with B. tabaci could support their host’s fitness and survival. These findings reveal the endosymbionts associated with B. tabaci and T. vaporariorum in Iraq and the UK, respectively. Further investigation is needed to understand the roles of these symbionts in both countries
Evaluation of the efficiency of some chemical herbicide in eliminating Raphanus raphanistrum L. weed associated with wheat crop
Authors: Jabbar Younis Muneam , Al-Farttosi Hameed Abd Khashan , Farhood Ali Nadhim
Published: December 2023

In order to assess how effectively different herbicides work in          controlling the wild radish weed that are connected with the growth of the wheat crop, The experiment included one factor he four types of chemical herbicides: Navigator, Tatsteler, Decimate and Mark zone,in addition to comparison treatment. and with three replications, according to the randomized complete block design (R.C.B.D). When the process of preparing the soil of the field was carried out, artificial infection of the wheat seeds the Al-Wafia variety was carried out, by adding 0.5 gm of wild radish weed seeds. After that, the polluted wheat seeds were sown, and when the wild radish weeds reached the appropriate stage for control, herbicides were added according to the recommendation of the producing company some characteristics were taken from the wild radish weed after 60 and 90 days of control, as well as some characteristics of the wheat plant and its yield components, results were as follows: excellence the two herbicide, Navigator and Decimate, were superior in reducing most of the studied traits of wild radish weeds, as shown the results show Navigator excelled by giving it the highest average of chlorophyll  index, which reached 50.71 SPAD, and in flag leaf area, which averaged 49.64 cm, in ddition to its superiority in grain yield, with an  average of 5.83 tons. ha-1 and in the harvest index also gave the  highest average of %36.92, as it was noted that Tatsteler herbicide was superior in the tillers number with an average of 472.33 tiller m-2 and in the spikes number of also excelled with an average of 423.57 spike m-2 . as for the Mark zone herbicide, it excelled in the weight of 1000 grains, with an average of 40.10 g. also it was noted that Decimate had superiority in biological yield with an average of 15.13 ton ha-1, but it did not differ significantly from the averages of Navigator and Tatsteler, which were 15.09 and 15.06 ton ha-1 respectively.
The effect of different levels of protein and fat on dietary preference and survival of western honey bees workers, Apis mellifera L.
Authors: Al-Moussawi Azal Abdulaziz Ibrahem , Al-Esawy Mushtaq Talib Kareem
Published: December 2023

This study was conducted at the bee laboratory in the Faculty of Agriculture at the University of Kufa to investigate the possibility of using artificial feeding with protein and fat as an alternative to pollen. The study also aimed to examine the preference of nurse honey bees for artificial feeding mixtures and their consumption compared to a sugar solution (Sucrose 1 M ), and finally to determine the effect of feeding mixtures on the lifespan of nurse bee workers. The results showed that the highest consumption rate of nurse honey bees was in the control treatment (Sucrose 1 M ) at 72.57 microliter /bee /day, while the lowest consumption rate was 27.70 microliter /bee /day in the treatment (15:1 P: F). The consumption rates in the treatments (0:1 P:F), (1:1 P: F), (5:1 P: F ), and (10:1 P: F) were 64.80, 47.24, 44.70, and 32.42 microliter /bee /day, respectively. The results also revealed that the highest survival rate was in the control treatment (Sucrose 1 M) at 96.25%, while the treatment (0:1 P: F) had the lowest survival rate at 67.50%. The survival rates in the treatments (1:1 P: F), (5:1 P: F), (10:1 P: F), and (15:1 P: F) were 81.25%, 73.75%, 83.75%, and 86.25%, respectively.
Optimization and validation for identification of volatile organic com-pounds released from Trogoderma variabile Ballion using headspace solid-phase microextraction and GC-FID/MS
Authors: Alshuwaili Thamer , Mohammedali Mushtak Talib , Lahuf Adnan A. , Koli Pushpendra , Agarwal Manjree
Published: December 2023

Volatile organic compounds (VOC) emitted by Trogoderma variabile at different life stages (larvae, female and male) can help us to understand the chemical signals that are released by the beetle which can serve as biomarkers for diagnostic purpose. There are several factors that effect on the optimization of VOC extraction including, temperature, jar size, number of insects, duration of extraction, and gas chromatography (GC) conditions. This study used headspace solid phase microextraction (HS-SPME) fibre coupled with flame ionization detection (FID) and gas chromatography with mass spectrometry (GC-MS) to determine the optimal method for accurate, rapid and cost-effective extraction and identification of VOC from different life stages of T. variabile. The HS-SPME technique and the analytical conditions with GC and GCMS were optimized and validated for the determination of VOCs released from T. variabile. Selection of the number of insects was based on the height and the number of peaks. Results showed that 15 and 20 larvae and adults respectively gave the best number of peaks. Sixteen hours were optimized as the best extraction time for larvae and adults to get maximum number of emitted VOCs. The number of compound released from T.variabile different stages was 7, 9 and 11 for male, female and larvae respectively. Furthermore, some compounds were identified in all stages such as oxime-, methoxy-phenyl, 2(3H)-furanone, 5-ethyldihydro- and nonanal. Also, most of the compounds were significantly different in peak area between different life stages.
The efficiency of using integrated control agents to manage the Dubas bug Ommatissus binotatus lybicus De Berg (Homoptera: Tropiducidae) in Karbala Governorate
Authors: Tami Mohammad Abd Ali , Kareem Ali A. , Ali Muhsun Abid
Published: December 2023

This study aims to rate the efficiency of using chemical pesticides, bio-fungicides, and the interaction between them against the nymphal and adult stages of the Dubas insect (Ommatissus binotatus lybicus De Berg). Anyhow, the laboratory and field results of the pesticides significantly affected the treated phases. The field results of the treatments were significantly increased after around two weeks, as for the average percentage of death in the treated nymphs. It reached 89.29-75.03-72.5-71, respectively.  The results of the interaction treatments between fungal biocides (Beauveria bassiana, Paecilomyces sp, Beauveria bassiana, Metarhizium anisopliae, Metarhizium anisopliae, and Paecilomyces sp) were significantly increased after two weeks of treatment, as the average percentage of death of the treated nymphs reached 63.95 -77.19 -63.5, respectively. The laboratory results of the treatments were significant for the pesticides used after nine days of treatment, as the average percentage of death of the adults reached 86.01 - 39.25 -32.16 -36.81, respectively. Moreover, the interaction coefficients between the fungal biocides mentioned in the paragraph above were significant after nine days of treatment. The average percentage of treated adults' deaths reached 38.13 -39.64 37.57 - 86.02 to treat the interaction between the chemical pesticide Actara and B. bassiana. The chemical pesticide Actara excelled in the field experiment, as it gave the highest percentage of mortality when used at concentrations of 1-1.5 g/L after two weeks of treatment. The average percentage of nymphs killed was 89.29.

As for the laboratory experiment results, the chemical pesticide Actara was also superior, as it gave the highest mortality rate for adult females. The average mortality rate for adult females reached 86.01 after nine days of treatment compared to the rest of the treatments using other pesticides.
PKM. KEGIATAN PENGABDIAN MASYARAKAT PELATIHAN KEMAMPUAN VOCABULARY BAHASA INGGRIS MELALUI DEMOSTRASI PENGENALAN MAKANAN 4 SEHAT 5 SEMPURNA
Authors: Ni Komang Purwaningsih  , Si Putu Agung Ayu Pertiwi Dewi  , Ni Putu Lindawati
Published: December 2023

The ability to apply English through demonstrations eating 4 healthy 5 perfect food is the ability to know all the words about fruit and vegetables, or vocabulary, or diction that refers to healthy 5 perfect concepts, to express ideas in speaking and in writing English. The purpose of this social activity are: (1) imitate pronouncing English words according to the pictures, (2) Mention English words according to the pictures, (3) match the sounds of English words with the pictures that symbolize them, and (4) link the pictures and the written language words English. The method used is socialization and mentoring. Presentation of material on improving English skills by learning vocabulary through demonstration methods of eating behavior 4 healthy 5 perfect. The participants in this activity were 16 Neo Genesis Kindergarten students. The results of this social activity are: (1) carrying out an approach method through field observations, (2) the team provides facilities in the form of delivering materials, prizes, and providing consumption in the form of healthy food such as fresh fruit to students at Neo Genesis Kindergarten, Dalung, district North Kuta, Badung regency. (3) training through materials, games and question and answer sessions, (4) evaluation of activities regarding the understanding of extension participants. From the results obtained, it can create PKM activities that are useful in relation to improving English skills by learning vocabulary through demonstration methods of eating behavior 4 healthy 5 perfect.