bluuebunny/crossref_metadata_2025 huggingface dataset:
Umbelliferone Loaded Nanocarriers for Healthcare Applications
Authors: Singh Deepika , Rahman Mahfoozur
Published: March 2020

Background:

Nanotechnology brings innovation in the healthcare sector and revolutionized
the therapeutic domain in recent years. It provides better health facilities and bring advancement in the
field of science and technology. Nanocarriers are extremely small structure and involve synthesis, designing,
application of medicament in the size range of 1-100 nm. Nanocarriers are especially explored
for their chemical, physical and biological activity. Good understanding of all these properties
is necessary to increase the therapeutic application of nanocarriers in different fields, by abating the
hazards to creatures and the environment. The goal of this article is to review the developed nanocarriers
of Umbelliferone from the viewpoints of research trend, synthesis, targeting mechanism, its clinical
applications and future perspective.

Method:

A wide variety of nanocarriers system of umbelliferone have been developed, such as
nanoshell, nanowire, nanoparticles, solid lipid nanostructure, dendrimers, nanoemulsion, nanosponges,
etc. Nanosystem of umbelliferone is prepared by two approaches i.e. top-up and bottom down method,
as well as their potential application in several areas, is presented in this paper.

Results:

Umbelliferone, a 7-hydroxycoumarin is widely available Rutaceae and Apiaceae families and
termed as a therapeutic active agent. It is a derivative of coumarin and contain a heterocyclic ring with
the improved biological property. In the literature survey, antifungal, antibacterial, antihyperglycaemic,
anti-cancer, anti-diabetic, anti-arthritic, antioxidant and anti-inflammatory property
are reported. Nanocarriers encapsulated umbelliferone have been recommended and explored to treat
various types of diseases.

Conclusion:

This article upsurges the understanding of the nano-based delivery system of drug Umbelliferone
in the field of biomedical application along with the safety concerns. A future perspective
on the fabrication of nanocarriers of umbelliferone, scaling up technique, therapeutic efficacy and environmental
protection is presented in the review. This advocates that numerous possible application
of this drug for the future works are available for the commercialization.
Distributed Ledger System for Stock Market Using Block Chain
Authors: Johri Era , Kantariya Bhakti , Gandhi Rachana , Mistry Unnati
Published: March 2020

Background:

Lacuna of the traditional stock market systems overtime has been bridled
by BlockChain Technology. Used cases designed in BlockChain Technology has a flair to deal with
the problems in the financial sector. Most vituperative outburst is related to stock markets where the
centralization of the clearing house increases the dependency on the central system. Centralization
of the clearing houses increases the risks and delay in response to the users of the system. Traditionally,
stock market players need to endure the complex multi-layer process of pre-trading, trading
and post-trading settlements. The processes in these systems were time consuming and cost inefficient
in terms of resources utilized due to the role of intermediaries.

Objective:

The objective of this paper is to propose a system which will embark the issues of processing, traceability, transparency, and availability of stocks using BlockChain Technology.

Method:

We offer a decentralized system for the stock market users, and as a result, the intermediaries
become expendable. The rules and regulations will execute within every smart contract for
every trade transaction being regulatory.

Results:

This paper discusses various solutions to the problems arise due to current centralized or decentralized systems.

Conclusion:

We will discuss aspects like security and transparency of the proposed system while
concluding the paper.
COMPARATIVE ANALYSIS OF THE DIAGNOSTIC VALUE CLINICAL GRADING SCALES FOR FACIAL NERVE AT CHILDREN WITH FACIAL NERVE NEUROPATHY
Authors: Liskevych I. I. , Pityk M. I.
Published: March 2020

In the article there is the comparative analysis of major national and foreign clinical scales of assessment of "facial nerve - facial muscles" dysfunction, considered the advantages and disadvantages of using these scales in clinical practice.
CLINICAL-NEUROPHYSIOLOGICAL FEATURES IN PATIENTS WITH REPEATED CEREBRAL ISCHEMIC HEMISPHERIC STROKE IN ACUTE PHASE OF DISEASE
Authors: Kozolkin O. A. , Novikova L. V.
Published: March 2020

Summary. In order to study the clinical and neurophysiological features in patients with recurrent cerebral ischemic hemispheric ischemic stroke (RCHIS), a comprehensive clinical-paraclinical study of 49 patients (28 men and 21 female, mean age 72 (63; 76) years) in the acute period of the disease was conducted. It was found domination of mild and moderate dementia, the median total NIHSS score in the debut of the disease consisted 10 (7; 13), which corresponded to the average severity of the stroke. It was found that the parameters of δ-rhythm APS, δ-rhythm RSP and β rhythm  relative spectral power have the strongest correlation with level of neurological deficit by NIHSS score and with  level of disability by MRS, as well as parameters of occipital-frontal grade of  βhi-rythm and hemispheric asymmetry of αlo-subband correlated with the level of cognitive deficit.
FACTORS OF INFLUENCE ON PAIN INTENSITY AND FUNCTIONAL ACTIVITY OF PATIENTS WITH BACK PAIN OF DIFFERENT LOCALIZATION
Authors: Maslova I. G. , Mykhailovska N. O. , Slobodin T. M.
Published: March 2020

In order to identify the probable factors of the effect on the intensity of the pain syndrome and the parameters of the functioning of patients with back pain, depending on the location of the pain syndrome and concomitant pathology, 139 patients with non-specific back pain who were in inpatient treatment in the medical and sanitary part of JSC "Motor -Sich "with the first detected acute pain syndrome and acute exacerbation of chronic.

The results of the study revealed a decrease in the level of physical functioning, deterioration of vital activity and the state of general and mental health (on the scale of SF-36) in patients with exacerbation of chronic pain, the lowest indicators of vital activity, social functioning, mental health and a high level of anxiety and depression - in patients with cervical and cranial localization of pain syndrome, despite the fact that patients with localized pain in the lower back are markedly higher levels of pain not only for YES, but also zg BP bottom axis scale SF-36. Patients with a combination of arterial hypertension and diabetes have been shown to have chronic pain syndrome.
THE PECULIARITIES OF THE QUALITY OF LIFE OF PATIENTS, SUFFERED FROM ANEURYSMAL SUBARACHNOID HAEMORRHAGE
Authors: Duve K. V.
Published: March 2020

The analysis of data from a number of scientific sources shows that even those patients, with favorable outcomes after suffering from aneurysmal subarachnoid hemorrhage (aSAH), may often experience a decline in quality of life (QoL), both at the physical and psychosocial levels. The influence of functional dependence on the patient’s quality of life remains controversial, because among the number of patients, who save the ability of self-care, there exists a part of those, who are not able to return to their previous lifestyle, kind of activity, they have difficulties in their relationships and emotional disorders.

The aim of study was to assess the quality of life of patients in recovery and residual periods of aSAH.

Material and methods. We examined 114 patients (64.91 % - males, 35.09 % - females). The patients’ quality of life was studied by using the questionnaire SF-36. The control group consisted of 20 healthy participants, matched by age and gender.

Results. The significant decrease in QoL of patients was observed in all scales, with the exception of physical functioning, vital activity and social functioning. It should be noted, that "mental health" scale rates correlated with the level of anxiety (r = -0,55) and depression (r = -0,61). In the different age groups, the QoL indicators were almost identical, with the exception of "physical functioning" component, because older patients received a lower score for this scale (p<0.01). Patients with a moderate level of disability were observed with a decline in all QoL categories of the scale SF-36. Patients, who were totally independent, had also a significant decline in all QoL scale components, with the exception of physical functioning.

Conclusions. We found the decrease in QoL of patients in recovery and residual periods of aSAH, which does not depend on one’s level of functional dependence. The influence of anxiety (r = -0,55) and depression (r = -0,61) on the subscale "mental health" was established.
NEW DEVELOPMENTS IN MORPHOLOGICAL DIAGNOSIS OF ISCHEMIC STROKE IN THE VERTEBRO-BASILAR BASIN
Authors: Hryhorova I. A. , Ibragimova O. L. , Eskin O. R. , Tykhonova L. V. , Hryhorov N. N.
Published: March 2020

Clinical manifestations of ischemic stroke in the VBB depend on many factors and their diagnosis is often difficult due to atypical clinical presentation and rare classic symptoms [1; 2; 8]. The pathomorphological comparison of changes in the brain in patients who died of ischemic vertebrobasilar and carotid stroke. In VBB stroke stenotic lesion precerebral and intracerebral vertebral artery segments are of most important etiopathogenetic importance. Maximum intensity of the pathological changes in ischemic stroke occurs at 2-3 days of onset of irreversible damage of structural elements of the nervous tissue in the area of the primary ischemic lesion.
POST-INFLATED GLENOHUMERAL PAIN
Authors: Muratova T. M. , Khramtsov D. M. , Kotov S. A.
Published: March 2020

The aim of the study was to assess the prevalence of post-storoke glenohumeral pain and the effectiveness of its diagnosis and treatment in a university clinic. It was shown that pain in the shoulder joint of the parectic limb is recorded in 28.3% of inpatients and 20.3% during the first weeks after discharge. At controlled visits 3 and 6 months later, in 61.5% of cases, satisfactory clinical effects were achieved by reducing the intensity of pain to 1.8 ± 0.1 scores, and in the rest of the patients to achieve complete control of the pain. It was established that the use of preventive measures can reduce the number of patients with post-venous glomerular syndrome, moral pain.
CRYPTOGENIC STROKE? LOOK FOR THROMBOPHILIA
Authors: Genyk S. I. , Genyk S. M. , Gryb V. A. , Genyk Ya. I. , Maksymchuk L. T. , Doroshenko O. O. , Sorokhman A. V. , Gerasymchuk V. R.
Published: March 2020

About 25% of ischemic strokes remain without an established cause. The article describes the characterization of some hereditary and acquired thrombophilias, which play a significant role in genesis of stroke. One of the ways to solve the problem of etiological diagnosis of thrombotic states is to identify the markers of hereditary or acquired pathology and to conduct molecular genetic typing of the hemostasis system factors. Thrombophilia screening is required for all patients with ischemic strokes of unknown etiology.
DYNAMICS OF RADIOGENIC CHANGES IN THE INTENSITY OF LIPID PEROXIDATION PROCESSES IN THE BLOOD OF ANIMALS UNDER DIFFERENT MODES OF IRRADIATION
Authors: Petryna L. G. , Moiseienko M. I.
Published: March 2020

Experimental studies were performed on male Wistar rats. Single exposure of animals at doses of 1.0, 5.0, and 9.0 Gy was performed from a source with dose rates of 0.001, 0.01 0.1, and 1.0 Gy/min. The content of diene conjugates was determined at 0.5, 1, 2, 4, 6, 8, 10, 15, 20, and 30 days after exposure. It was found that the content of diene conjugates of blood varied wavy. The relative change in early products per 1 Gy irradiated at doses of 5.0 and 9.0 Gy was 1.5-2.0 and 4-5 times lower, respectively, than in animals irradiated at dose 1.0 Gy. After 4, 6, 8, 10 days, a clear dependence of the indicator on the magnitude of the radiation dose rate was not observed.

The dynamics of accumulation of early LPO R products in the blood of rats, irradiated over a wide range of doses and capacities, indicates the nature of the development or inhibition of free radical oxidation processes.
MODESTY AS A DOCTOR’S MORAL TRAIT OF CHARACTER
Authors: Stefurak V. P. , Mykytyn T. V. , Dovganych N. V.
Published: March 2020

The paper deals with a mentor’s part in forming students’ personality, future professionals in the fields of medicine and biology. The main emphasis is given to their moral traits of character, namely to modest behavior as well as communication competence with future patients, such as a sincere, gentle word as a prerequisite for the behaviour of an educated and decent doctor.
THE INTENSITY OF OXIDATIVE MODIFICATION OF PROTEINS AND PEROXIDATION OF LIPIDS IN THE BLOOD SERUM, BRAIN, LIVER AND PANCREAS TISSUES OF RATS WITH INSULIN RESISTANCE AND CONGENITAL IODINE DEFICIENCY
Authors: Stetsevyat V. B. , Voronych-Semchenko N. M.
Published: March 2020

The results of the study about the nature of oxygen-dependent processes in rats that were on a high-fructose diet for 8 weeks under conditions of adequate iodine supply and congenital iodine deprivation is presented in the article. The significant activation of peroxide oxidation of proteins (by increasing the aldo- and keto-derivates of a neutral nature) and lipids (increased of diene conjugates content and products, that are responsible to thiobarbituric acid) of animals with insulin resistance was found. An aggravating factor in the course of these processes is a congenital iodine deficiency. The changes of oxidative modification of proteins in animals with congenital iodine deficiency had multidirectional character, and processes of lipid peroxidation mainly increased. The most pronounced changes of the studied processes were observed in the liver and pancreas of animals with insulin resistance against the background of congenital iodine deficiency.
ATEROSCLEROSIS AND INFLAMMATION: GENERAL PATHOGENETIC MECHANISMS
Authors: Kotiuzhynska S. H. , Umanskyy D. O.
Published: March 2020

According to modern notions, atherosclerosis is a complex multifactorial process in which the mechanisms of development involved endothelial dysfunction, inflammation, dyslipidemia, disorders of the blood coagulation system, and the like. Polyunsaturated fatty acids are a source of biologically active substances that regulate metabolic processes in the body. It is known that during the development of inflammation, biologically active agents are synthesized and accumulated, which both provide a protective function, and play the role of triggers or lead to the development of additional alteration and the formation of pathological systems.

Purpose of the study. The purpose of the work is to study the functional state of the lipid transport system and to ascertain the role of polyunsaturated fatty acids in the mechanisms of atherosclerosis.

The analysis of the functional state of the lipid-transport system of 221 patients with diffuse cardiosclerosis with different nosological forms revealed a disturbance of direct and reverse transport of cholesterol, but with varying degrees of orientation. Significant increase in the content of saturated fatty acids by 7.51% and reduction of unsaturated.

Reducing the level of polyunsaturated fatty acids is a consequence of increased formation of prostaglandins and leukotrienes in inflammatory processes of the vascular wall, and indicates a disbalance in the regulation of lipid homeostasis. The deficiency in polyunsaturated fatty acid cells for many years models the high potential of endothelial dysfunction, which can be a pathogenetic mechanism not only for atherosclerotic lesions, but also for inflammation of the vessels.

Conclusion. The recognition of atherogenesis as an active process rather than a cholesterol storage disease has highlighted some key inflammatory mechanisms. In our opinion, the local violation of the transport of lipids in the tissue is at the heart of the atherosclerotic lesion of the vascular wall, which develops irrespective of inflammation in the vessel wall, but substantially potentiates them due to the action of inflammatory mediators.
EFFЕCIIVENESS OF USING NEW METHODS AND METHODS OF LEARNING THE UKRAINIAN LANGUAGE AS A FOREIGN IN MEDICAL UNIVERSITY
Authors: Lychuk S. V.
Published: March 2020

The article attempts to identify effective methods of teaching Ukrainian as a foreign language and to base them on the European experience. The most commonly used methods in the European practice of foreign language teaching are characterized: communicative, project, audio-lingual, distance, intensive and blended learning. The advantages of the blended learning system are examined. An interpretation of the term "blended learning" is proposed. The features of the organization of online learning and the structure of blended learning are described. The data of the conducted survey are presented: a) teachers conducting classes in Ukrainian as a foreign language; b) foreign students from different countries. Questionnaire was developed for the survey.

The article proposes some tasks for teachers of Ukrainian as a foreign language, commenting on the specifics of different models of blended learning.

Based on the results of the survey, the respondents outlined effective methods of teaching a foreign language, identified factors that influence the use of the blended learning model of future doctors when teaching Ukrainian as a foreign language.

The advantages and prospects of using blended learning in the educational process of a higher medical institution are analyzed. The results of the study strongly suggest that the blended learning model opens up new possibilities for presenting educational material in a new and accessible form for students.
Sistem Pendingin Termoakustik Dengan Menggunakan Stack Acak dan Penukar Kalor Tambahan Dalam Resonator
Authors: Yumnawati Yumnawati , Murti Prastowo , Achmadin W N , Setio Utomo Agung Bambang
Published: March 2020

Telah dilakukan penelitian pada kinerja sistem pendingin termoakustik menggunakan stack acak dan kemudian ditingkatkan lagi kinerjanya dengan memberi penukar kalor tambahan sebagai auxiliary heat exchanger. Resonator yang digunakan berbentuk silinder dengan satu ujung tertutup, sedangkan ujung yang lain dihubungkan dengan speaker. Gelombang bunyi yang dihasilkan dari speaker dalam resonator akan memberi pengaruh pada medium udara dalam tabung resonator. Dalam hal ini pengaruh utamanya pada daya pendinginan, sehingga perlu dibuat sistem yang cukup efisien. Diharapkan dengan terwujudnya sebuah pendingin termoakustik menggunakan penukar kalor tambahan dapat meningkatkan kinerja sistem.
Visualisasi Fungsi Legendre dan Perilaku dari Permukaan Bola Harmonik dengan Menggunakan Bahasa Pemrograman Matlab
Authors: Setiawan Ari
Published: March 2020

Telah dilakukan penelitian yang berhubungan dengan medan potensial gravitasi di permukaan bumi yang merupakan persamaan harmonik bola. Harmonik bola tersebut merupakan penyelesaian dari persamaan Laplace, dalam sistem koordinat bola. Persamaan ini dikenal dengan Associated Legendre Functions. Pada penelitian ini dikembangkan visualisasi Associated Legendre Functions atau disebut juga dengan Spherical Harmonic Functions dalam tampilan 1D, 2D, 3D dengan menggunakan pemrograman MATLAB. Telah berhasil dikembang visualisasi dalam koordinat bola untuk fungsi r + Pnm(x) dengan r = 5 dan Pnm(x) yaitu Associated Legendre Functions untuk derajat n = dari 1 sampai 7 dan dengan orde m ≤ n.
Penyelidikan Prospek Pasir Besi di Dusun Sungai Topo, Desa Sungai Teluk, Kecamatan Sangkapura, Kabupaten Gresik menggunakan Metode Magnetik
Authors: Karimah Karimah - , Irjan Irjan
Published: March 2020

Penelitian yang telah dilakukan dikawasan pantai dusun sungai topo desa sungai teluk kecamatan sangkapura kabupaten gresik bertujuan untuk mengetahui pola sebaran pasir besi dan mengetahui struktur bawah permukaan di daerah penelitian. Daerah penelitian memiliki formasi Quarter Aluvial yang merupakan endapan sungai dan pantai yang tersusun dari kerakal, kerikil, lempung, lumpur, dan pasir. Akuisisi data interpretasimagnetik dalam penelitian ini telah dilakukan pada bulan juli 2018, diperoleh 103 titik pengamatan dengan jarak 80-100 m antar titik pengamatan. Pengambilan data dengan menggunakan Proton Procession Magnetometer (PPM) diperoleh medan magnet total dititik pengamatan pada daerah penelitian. Hasil interpretasi kualitatif dengan koreksi variasi harian, koreksi IGRF, kontinuasi keatas dengan ketinggian 200 m dan reduksi ke kutub. Hasil analisis menunjukkan rentang nilai anomali medan magnet dari -70nT sampai 70 nT. Hasil interprtasi kuantitatif dari pemodelan 2D menggunakan oasis montaj, diperoleh beberapa model benda anomali bawah permukaan. Model benda anomali dengan nilai suseptibilitas 15x10-6 satuan SI diinterpretasi sebagai pasir besi yang berselingan dengan lanau, lempung, pasir dan kerikil.dari formasi Alluvium. Berdasarkan data anomali lokal, data singkapan, stratigrafi, pada area penelitian memiliki anomali tinggi dan anomali rendah dengan bentuk klosur tertutup yang tersebar tidak merata di area penelitian, dan memiliki lapisan struktur bawah permukaan yang tersusun dari pasir halus, pasir yang bercampur dengan pasir besi, gamping bercampur dengan batu pasir, dan gamping dengan kedalaman 50 meter dibawah permukaan.
Universos poéticos en complicación: un encuentro entre filosofía y crítica literaria
Authors: Aurora Pimentel Luz
Published: March 2020

Artículo
Entre el edén y la barranca. La dimensión mágica y trágica de Under the Volcano
Authors: Alcázar Jorge
Published: March 2020

Artículo
Los monstruos de Frankenstein
Authors: Fe Marina
Published: March 2020

Artículo
Frankenstein y Blade Runner. Variaciones sobre el tema de Prometeo
Authors: Novell Noemí
Published: March 2020

Frankenstein y Blade Runner. Variaciones sobre el tema de Prometeo
Las rutas de la culpa y de la seducción en el Ulises de James Joyce
Authors: Aurora Pimentel Luz
Published: March 2020

Las rutas de la culpa y de la seducción en el Ulises de James Joyce
Sobre la obra literaria de Madame Blavatsky
Authors: Ricardo Chaves José
Published: March 2020

The main goal of this essay is to present Helena P. Blavatsky, widely known as a great occultist of the XIX century, as a fiction writer, that used the rethorical powers of the fantastic to develop some stories to attract a wider audience. Her traveling chronicles around India are very interesting because of her skillful narrative and her Russian point of view, that differs from writers from England or India.
Fabulous Awakenings: The Ethics of Metafiction in La vida es sueño by Calderón de la Barca and Some Tales from the Arabian Nights
Authors: González Treviño Ana Elena
Published: March 2020

La manipulación de la realidad al estilo de La vida es sueño produce una estructura narrativa en planos asociada con la metaficción. Dicha estructura se puede encontrar también en varios cuentos de Las mil y una noches. Este ensayo busca describir y tipificar esta manipulación citando, además de la obra de Calderón, los cuentos “El durmiente despierto”, “La historia del príncipe Camaralzamán y la princesa Budur” y “La historia de Nuredín Alí y Bedredín Hasán”. Si bien en la metaficción contemporánea es el autor quien usualmente manipula la realidad, en la obra de Calderón y en los cuentos citados es una figura de poder, natural o sobrenatural, la que interrumpe el curso normal de la acción. Se describe la dimensión ética del acto, así como las consecuencias de los tres tipos de despertar que viven las víctimas de esta interferencia.
La relación entre poesía e historia en el joven Octavio Paz
Authors: De Teresa Ochoa Adriana
Published: March 2020

Este artículo explora la perspectiva desde la cual el joven Octavio Paz se inscribió en el debate central de la tercera década del siglo XX, que oponía dos modelos antagónicos: el del arte comprometido, al servicio de una ideología, y el del arte puro, ajeno a la historia y la realidad extrapoética. En 1938, al integrarse como responsable de la revista Taller, Paz contribuyó de manera destacada a mantener una postura independiente y a explorar las complejas relaciones entre la poesía y la historia en el mundo contemporáneo, tema que sería central para la nueva generación de escritores mexicanos. En poetas como T. S. Eliot, Novalis y Rimbaud, Paz encuentra un modelo que le permitirá conciliar “lo eterno con lo efímero” y plantear que la verdadera poesía consiste en la cristalización de un presente absoluto que jamás rehúsa a la fidelidad con su tiempo.
La otredad gótica y la figura del doble
Authors: Alcalá González Antonio
Published: March 2020

El encuentro con un doble es un recurso común en la literatura gótica que lleva al protagonista a cuestionar y dudar acerca de la concepción occidental del ser humano como una identidad unificada. El doble inicia como una proyección hacia el otro de todo aquello desagradable que, conscientemente o no, reconozco dentro de mí mismo. De este modo, la aparición de dobles en la literatura gótica hace posible el justificar los crímenes del protagonista, así como personificar los límites de lo admisible y señalar hacia los riesgos de buscar transgredir más allá de tales barreras; estos dobles permiten a sus creadores expresar preocupaciones personales de diversa índole. En Latinoamérica, Jorge Luis Borges y Carlos Fuentes retoman la figura gótica del doble para explorar la presencia de lo inadmisible dentro de sus protagonistas, quienes, al reconocerse como seres abyectos, encuentran en el doble la posibilidad para escapar a tal condición.
L' essence humaniste du roman contemporain
Authors: Landais Choimet Monique
Published: March 2020

Al instituir la actividad literaria como verdadero trabajo, Gustave Flaubert provocó una suerte de avalancha que sigue, hoy en día, arrasando con los cánones de la narrativa tradicional: carácteres, intrigas, sentimientos. La Nueva Novela, a su vez, llena de recelo y sospecha, hizo de cada obra la concreta búsqueda de nuevas formas literarias en la que el objeto, el sujeto y el lenguaje entrarían en una crisis que conduciría, afortunadamente, a principios de los ochentas, a la aparición de un nuevo género novelesco ecléctico, enriquecido por la simbología y la alegoría, la intertextualidad y la pluridisciplinaridad, los juegos de lenguaje y de narratividad. Este reencantamiento poético y mágico nos abre, una vez más, una ventana esencialmente humanista hacia el recién estrenado siglo XXI.
El arte del encantamiento en la narrativa e Salman Rushdie
Authors: Piñeiro Aurora
Published: March 2020

La seducción y la palabra, el arte de narrar son temas centrales de la última novela de Salman Rushdie. En este ensayo se propone una lectura de The Enchantress of Florence, de Rushdie, desde la perspectiva de la “metaficción historiográfica”, concepto desarrollado por Linda Hutcheon y otros críticos de la narrativa posmoderna, como un análisis de la puesta en práctica de una poética de lo excéntricoo lo inestable que caracteriza a una buena parte de la narrativa escrita a partir de la segunda mitad del siglo XX.
El Holocausto en tanto tropos universal para experiencias históricas traumáticas
Authors: Seydel Ute
Published: March 2020

En su libro En busca del futuro perdido. Cultura y memoria en tiempos de la globalización (2002), Andreas Huyssen llama la atención sobre el desplazamiento del Holocausto, en tanto tropos de la historia traumática, a contextos norelacionados con el Holocausto histórico. A partir de sus planteamientos se analizarán en el presente artículo dos novelas: Morirás lejos (1967) de José Emilio Pacheco y Gefährliche Verwandtschaft (1989) de Zafer Şenocak. En la novela del escritor mexicano se aborda tanto el Holocausto perpetrado durante el Tercer Reich como los genocidios cometidos durante la Conquista e Inquisición españolas. A su vez, en la del autor alemán, de origen turco, el narrador autodiegético elabora la memoria familiar, por un lado, respecto al Holocausto y, por otro, en cuanto al genocidio de los armenios perpetrado durante el Imperio otomano. Así, ambas propuestas literarias contribuyen a la construcción de una especie dememoria histórica transnacional acerca de crímenes de guerra y delitos de lesa humanidad cometidos por regímenes autoritarios.
El equilibrio inestable de la Historia en Memorial del convento
Authors: Paula Arnaut Ana
Published: March 2020

En el presente trabajo se aborda la interacción entre la historia, la ficción y la ideología en la novela Memorial del convento, teniendo en cuenta las relaciones axiológicas y pragmáticas entre la obra y el lector. De esta manera se observa cómo la autenticidad histórica constituye uno de los pilares del escenario de la novela al mismo tiempo que permite el desarrollo del pilar ficcional, evidenciado sobre todo en la creación del personaje de Blimunda.
Buenos Aires Tour: nuevas maneras de leer la ciudad
Authors: González Akories Susana
Published: March 2020

Buenos Aires Tour (2003), obra colectiva elaborada por el artista visual Claudio Macchi, la escritora María Negroni y el artista sonoro Eduardo Rudnitzky, presenta un tejido interartístico tan complejo como fascinante que tiene a la ciudad como su tema principal. El acercamiento a la obra en este ensayo se enfoca en las estrategias a las que recurre cada uno de los creadores para construir un texto que nos permite conocer la capital porteña desde un ángulo pocas veces considerado. A partir de la ocurrencia, la glosa, el detalle nimio, todos ellos recogidos o registrados en esos espacios públicos urbanos condenados al abandono y al anonimato, esos “no-lugares”, esta propuesta no sólo invita un recorrido múltiple, abierto e intermedial, sino que nos enseña a leer e interpretar la esencia urbana y sus referentes de una forma distinta.
La superposición de la vida y la muerte en 2666 de Roberto Bolaño
Authors: Tornero Salinas Angélica
Published: March 2020

El objetivo de este artículo es explorar, en la novela 2666, del escritor chileno Roberto Bolaño, la ficcionalización del crimen, a partir del análisis e interpretación de las dos partes de la novela en las que se aborda directamente la temática: “La parte de los crímenes” y “La parte de Archimboldi”. En ambas “partes”, las voces narrativas toman distancia de los acontecimientos, lo cual conduce a los lectores a experimentar la pérdida de la línea que divide a la muerte de la vida. En Santa Teresa, en donde se asesina a las mujeres, y en el sitio ubicado en Polonia, a donde llegan los judíos, la vida y la muerte se imbrican. Los que vivenahí, ya están muertos.
El valor del francés en el mundo: más allá de la utilidad
Authors: Gallardo Uribe Marco Antonio
Published: March 2020

En el marco del coloquio Pluralidad de las Lenguas-culturas, en la mesa redonda intitulada “¿Por qué estudiar letras y lenguas modernas?”, se expone la diferencia entre la utilidad y el valor en el aprendizaje de la lengua y las letras modernas (francesas).
Conciencia, condición y estado trágicos en el pensamiento de Albert Camus
Authors: Padilla Longoria María Teresa
Published: March 2020

En este artículo nos proponemos mostrar que el punto de partida antropológico en el pensamiento de Albert Camus es el estatus trágico de los hombres, el cual implica el reconocimiento y la conciencia de nuestra condición y estado de seres mortales, limitados y sufrientes. Para exponer nuestro caso recurriremos a cinco de sus obras: El extranjero, en donde se muestra la impronta inmanente y autosuficiente del heroísmo de Meursault; El mito de Sísifo, como un canto al absurdo ante la ineluctabilidad victoriosa del destino trágico de los hombres; La peste, como crónica objetiva de guerra que enuncia la esencia contradictoria de la naturaleza humana, y El hombre rebelde y Las cartas a un amigo alemán, como testimonios de una rebeldía sin concesiones en cuanto lucha contra el absurdo inexorable de la vida humana. Haremos ver que la propuesta final de Camus alcanza su más alto refinamiento ético-estético como posible salvación antropológica en el binomio bondad-belleza arraigado a una búsqueda de justica telúrica.
Albert Camus: traductor
Authors: Isibasi Pouchin María Elena
Published: March 2020

Albert Camus ha sido, sin duda alguna, uno de los autores franceses del siglo xxmás leídos. Sin embargo, pocos son los estudios que abordan su quehacer de traductor.En búsqueda del lenguaje trágico propio de la época en que vive, Camusse aventura en la traducción y adaptación de dos obras españolas de los Siglos deOro, de una obra de Dino Buzzati y finalmente de una de William Faulkner. Elresultado, en ocasiones más creativo que fiel, da cuenta de su propia poética.
La "escrupulosa mezquindad" de la escritura en Dublineses de James Joyce
Authors: Pimentel Luz Aurora
Published: March 2020

De acuerdo con la intención manifiesta de Joyce de escribir los cuentos de Dublineses“en un estilo de escrupulosa mezquindad”, este artículo aborda la coleccióntomando en cuenta el contexto histórico que explica el deterioro de Dublín—patente en las descripciones de la ciudad— a partir del Acta de la Unión de1801 y el desastre humano que significó la gran hambruna de mediados del sigloXIX. En este contexto de depresión urbana y económica —agravada por la obsesiónque tiene el irlandés de emigrar, “de huir de la ‘isla condenada que se moríade hambre’ y encontrar un refugio en otra parte”— se analiza, en un primermomento, la temática general de los cuentos, para luego particularizar el análisisen algunos de ellos —“Las hermanas”, “Una nubecilla” y “Los muertos”. Destaca enel análisis no sólo la “escrupulosa mezquindad” del estilo, el cual podría considerarsecomo la marca del sobrio realismo de los cuentos, sino la vertiente simbólicaque reside en lo no dicho, en la historia virtual, aquella que por la técnicanarrativa de la indirección no ha sido contada, la historia ausente (gnomon) queproyecta su sombra o irradia su luz en la epifanía típicamente joyceana; todoaquello, en fin, que constituye la dimensión poética y simbólica de los relatos deDublineses.
Dos concepciones de la razón: una confrontación de Thérèse Philosophe con la filosofía moral kantiana
Authors: Hiller Daniel Rudy
Published: March 2020

Saber si la razón es capaz o no de tener un influjo directo sobre la voluntad y, por lo tanto, sobre la libertad, es una de las cuestiones más debatidas en el pensamiento del siglo xviii. De su resolución en uno u otro sentido depende conocer si la felicidad o la moralidad constituye el fin último de la existencia humana. En este artículo se aborda este debate tomando como hilo conductor la confrontación de un texto representativo de la literatura libertina, Thérèse Philosophe,con la filosofía moral kantiana.
El rito de iniciación en La philosophie dans le boudoir del Marqués de Sade: tiempo hierático e isolismo
Authors: Ortega Villela Berenice
Published: March 2020

Proyectada mucho antes de la explosión revolucionaria y publicada hasta 1795, cuando Sade se encontraba libre después de haber pasado doce años de encierro en la Bastilla, La philosophie dans le boudoir es una de las tres novelas en las que el Marqués desarrolla los elementos del mundo narrativo perverso que lo ha trascendido. La nouvelle Justine ou les infortunes de la vertu, suivie de Juliette, sa soeur y la inconclusa Les 120 journées de Sodome completan la tríada de textos en los cuales se desarrolla lo que hemos llamado, de manera errónea,“sadismo”: el placer derivado de ejercer violencia sobre los otros. Dicho término, utilizado tanto por expertos como no para hablar de los temas de Sade no sólo es problemático por el hecho de que crea ideas preconcebidas acerca de lo que encontramos al enfrentarnos al texto sadeano, sino también porque deja de lado el término que el Marqués mismo creó para definir su concepción del ser en el mundo: el isolismo. Un poco olvidado de los estudios sadeanos, este término es producto de la experiencia en prisión de Sade y encierra una complejidad  idéntica a la construcción de los relatos que lo desarrollan. Este trabajo busca establecer la relación entre isolismo, encierro y temporalidad, a partir de algunos conceptos de la triple mimesis de Paul Ricoeur y del análisis de la estructura de La philosophie dans le boudoir.
Wolfgang Paalem y su visión relativista de integración del arte amerindio y precolombino al surrealismo
Authors: Barbosa Araceli María
Published: March 2020

En el contexto latinoamericano el primitivismo e indigenismo en el arte se vinculan al surrealismo una de las vanguardias artísticas del siglo XX a partir del interés mostrado por los más connotados representantes de este movimiento y su afán por establecer nexos entre los postulados plásticos y las estéticas de los pueblos originarios de América. A su vez, el contacto con las propuestas vanguardistas y sus lenguajes plásticos enriqueció el imaginario del discurso visual latinoamericano. En México la presencia del pintor austriaco Wolfgang Paalen resulta crucial en el acontecer artístico y la emergencia del surrealismo plástico a partir de 1939.
In vitro and in silico analysis of the effect of fluconazole, an antifungal drug, on DNA
Authors: Zarf Sumeyye , Arman Ibrahim
Published: March 2020

Fluconazole is an important antifungal drug used worldwide for the treatment of peritonitis and cryptococcal meningitis, urinary tract infections, esophageal tract infections and vaginal candidiasis. In this research, pUC19 plasmid DNA was treated with different concentrations of fluconazole in the presence of ascorbic acid, H2O2, iron, iron plus H2O2, copper and copper plus ascorbic acid, followed by agarose gel electrophoresis. Fluconazole?DNA interactions were investigated by UV?Vis spectrophotometeric titration and in silico methods. Even in the presence of an oxidative agent or a reducing agent, at higher concentrations of fluconazole, double stranded DNA was not broken more than usually found in human plasma. Fluconazole concentrations ? 88 ?M could protect 46 ?M of DNA against hydroxyl radicals produced in the reaction between 1.5 mM of FeSO4 and 6 mM of H2O2 while drug concentrations ? 44 ?M could not provide the protection. In addition, the drug could not protect DNA against ROS originating from the reaction between copper and ascorbic acid. The binding constant of fluconazole?DNA in UV-Vis spectrophotometry analysis and docking analysis was estimated to be 1.087?103 and 6.22?105 M-1, respectively.
MicroRNA-34 expression in gingival crevicular fluid correlated with orthodontic tooth movement
Authors: Zhang Bin , Yang Li , Zheng Weilong , Lin Ting
Published: March 2020

Objectives

To explore the expression of miR-34a and its effect on expression of matrix metalloproteinases (MMPs) during orthodontic tooth movement (OTM).

Materials and Methods

Twenty patients, age 12–18 years old, who underwent orthodontic treatment were enrolled. The expression of miR-34a and MMPs (MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, and MMP-14) were detected in gingival crevicular fluid by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction at different time points. The miR-34a mimics or inhibitors were transfected into human periodontal ligament (hPDL) cells, and the MMP expression was measured by ELISA.

Results

The miR-34 expression in GCF on both the tension and pressure sides after orthodontic treatment were significantly downregulated, while the levels of MMPs were significantly upregulated compared with baseline level. The levels of miR-34 and MMPs returned to baseline level 3 months after orthodontic treatment. The expression of miR-34 was negatively correlated with the expression of MMP-2, MMP-9, and MMP-14. After transfection with miR-34, the MMP-2, MMP-9, and MMP-14 expression by hPDL cells were significantly downregulated compared with miR-control and miR-34 inhibitor.

Conclusions

Downregulated miR-34 expression was positively correlated with MMP-2, MMP-9, and MMP-14 expression. The miR-34a transfection into hPDL cells inhibited expression of MMPs. The results suggest that miR-34a is involved in expression of MMPs during OTM.
Effect of fiber laser welding on solute segregation and proprieties of CoCrCuFeNi high entropy alloy
Authors: Fan Y. , Li P. , Chen K. , Fu L. , Shan A. , Chen Z.
Published: March 2020

The effect of fiber laser welding on solute segregation and proprieties of CoCrCuFeNi high entropy alloy was investigated. The microstructure and mechanical properties of the parent metal and the fusion zone were comparably studied. The parent metal was dendrite, with elemental Cu segregated to interdendrites owing to small bonding energies with Fe, Co, Ni, and Cr atoms. After laser welding, the microstructure in the center of the fusion zone was predominantly equiaxial grains, whereas that in the edge region was mainly columnar crystals oriented perpendicular to the fusion line. The segregation of Cu in the fusion zone is alleviated by grain refinement and molten pool agitation. Because of the fine-grain strengthening and precipitation hardening effect, the hardness and yield stress of the fusion zone are 12.84% and 26.87% greater than those of the parent metal, respectively.
Renovation of residential areas for benefit of builders, state and citizens
Authors: Грушина Ольга , Торгашина Ирина
Published: March 2020

The paper deals with the problem of residential housing renovation projects for benefit of builders, citizens and state. The numerous interpretations of the “renovation” term we understand here as a complete renovation of the housing stock, i.e. demolition of old buildings and construction of new ones in contrast to their reconstruction and modernization. In other words, the renovation is considered as an urgent city-planning challenge involving changes in the field of territorial planning. On the example of the classic "Khrushchev" quarter of Irkutsk city, the authors propose a pilot renovation project with the distribution of roles and expenditures of all participants. The analysis conducted allows drawing a conclusion that renovation will be beneficial to the builder only if budget funds are invested in these projects in order to compensate the costs related to temporary resettlement of citizens from demolished dwellings. Another prerequisite is the governmental repurchase of apartments intended for resettlement of citizens from demolished housing at the prices not lower than those set by the authorities in the region. Citizens are ready to support renovation projects in case of their returning to their former place of residence in conditions improved from the point of view of the living environment comfort. To ensure the profit of the builder, the living area of the newly commissioned housing should exceed the area of the demolished housing by no less than one and a half times, provided that cheap technologies of modern prefabricated housing are used.
Optimization Performance on Plate Fin Tube Heat Exchanger
Authors: Alam Mahtab , Rajput Dr. Dharmendra Singh
Published: March 2020

The main objective of the present work is to investigation of optimum design of plate fin tube heat exchanger using Computational fluid dynamic approach and maximizing thermal performance. There are total five designs of plate fin and tube heat exchanger are used in present work and CFD analysis have been performed in it to get maximum heat transfer. It has been observed from CFD analysis that the maximum heat transfer can be achieved from plate fin and tube heat exchanger with elliptical tube arrangement inclined at 30o with 23.22% more heat transfer capacity as compared to circular tube plate pin heat exchanger. So that it is recommended that if the plate fins and tube heat exchanger with inclined elliptical tube used in place of circular tube arrangement, batter heat transfer can be achieved.
The Process of Creating an Accessible Environment for People With Health Limitations and Disabilities as a Priority of Social Policy: Sociological Analysis
Authors:   Siberian State Industrial University, Terskova Svetlana Gennadyevna , Miryukova Maria Aleksandrovna ,   Siberian State Industrial University
Published: March 2020

The paper presents the concept of an accessible environment, the special legislative framework in the sphere of creating a barrier-free environment for people with disabilities and health limitations is re-flected. The authors considered the process of form-ing an accessible environment as a priority direction of social policy, the results of sociological research conducted by the methods of questionnaire survey and expert survey by interview method are repre-sented. On the example of a specific city it analysed the availability of objects and services for disabled persons in the priority areas of activity such as transport and housing, employment, culture and information. The state of the available environment at the current stage is also reflected. The basic prob-lems of its formation are identified, the priority tasks that require special attention and recommendations for their solution are formulated.
Adaptation of Young Teachers in High Schools: an Integrated Approach
Authors:   Head Headquarters of the All-Russian Military Training and Patriotic Social Movement «UNARMIA», Belyaeva Yekaterina Sergeevna
Published: March 2020

The study considers issues of the absence of an employee pool at educational institutions, the in-crease of an average age of high school teachers and the reluctance of young professionals to fill this niche. In the Nizhny Novgorod region a re-gional target program “Measures of Social Support for Young Specialists of the Nizhny Novgorod re-gion for 2011–2023” has been developed to solve the problem of young professionals’ adaptation. How-ever, the results of author's survey have shown that in addition to material incentives (provision of ac-commodation, vehicles and maintaining a certain level of wages), promoting adaptation of young specialists there are also needed social incentives, such as: a high status and public prestige of teach-ers in a society, possibility of social mobility and career growth, internships at institutions in the oth-er places, exchange of best practices, mentoring, social infrastructure of a place of residence, pres-ence of preschool/high school and additional educa-tion and training, community commitment, presence of necessary facilities at rural schools and building new schools. National projects that take into ac-count both material and non-material incentives are created to solve the problem of young profession-als’ adaptation.