bluuebunny/crossref_metadata_2025 huggingface dataset:
A Scoring System to Evaluate the Impact of SNPs in a Path Related Context to Study Behçet’s Disease Aetiology in Japanese Population
Authors: Ozisik Ozan , Meguro Akira , Mizuki Nobuhisa , Diri Banu , Sezerman Osman Ugur
Published: May 2018

Motivation

Genome-wide association study (GWAS) is a powerful method that can provide a list of single nucleotide polymorphisms (SNPs) that are significantly related to the pathogenesis of a disease. Even though in Mendelian diseases strong associations can be found for certain SNPs, in most of the complex diseases only modest associations can be identified from the GWAS. Therefore, the main challenge in such studies is to understand how multiple SNPs that have modest association with the phenotype interact and contribute to its aetiology. This can only be done via pathway based analysis of modestly associated SNPs and the genes that are affected by these changes.

Results

In this study, we propose DAPath, a Disease Associated Path analyzer tool for discovering signaling paths and the pathways that contain these paths which are subjected to cumulative impact of modestly associated variants. We applied our proposed method on Behçet’s disease (BD) GWAS dataset from Japanese population. Antigen Processing and Presentation pathway is ranked first with 16 highly affected paths. Th17 cell differentiation, Natural killer cell mediated cytotoxicity, Jak-STAT signaling, and Circadian rhythm pathways are also found to be containing highly affected paths.

Availability

The proposed method is available as a Cytoscape plug-in through https://github.com/ozanozisik/DAPath
Genome-wide sampling suggests island divergence accompanied by cryptic epigenetic plasticity in Canada lynx
Authors: Johnson J.B. , Murray D.L. , Shafer A.B.A.
Published: May 2018

Determining the molecular signatures of adaptive differentiation is a fundamental component of evolutionary biology. A key challenge remains for identifying such signatures in wild organisms, particularly between populations of highly mobile species that undergo substantial gene flow. The Canada lynx (Lynx canadensis) is one species where mainland populations appear largely undifferentiated at traditional genetic markers, despite inhabiting diverse environments and displaying phenotypic variation. Here, we used high-throughput sequencing to investigate both neutral genetic structure and epigenetic differentiation across the distributional range of Canada lynx. Using a customized bioinformatics pipeline we scored both neutral SNPs and methylated nucleotides across the lynx genome. Newfoundland lynx were identified as the most differentiated population at neutral genetic markers, with diffusion approximations of allele frequencies indicating that divergence from the panmictic mainland occurred at the end of the last glaciation, with minimal contemporary admixture. In contrast, epigenetic structure revealed hidden levels of differentiation across the range coincident with environmental determinants including winter conditions, particularly in the peripheral Newfoundland and Alaskan populations. Several biological pathways related to morphology were differentially methylated between populations, with Newfoundland being disproportionately methylated for genes that could explain the observed island dwarfism. Our results indicate that epigenetic modifications, specifically DNA methylation, are powerful markers to investigate population differentiation and functional plasticity in wild and non-model systems.

SIGNIFICANCE

Populations experiencing high rates of gene flow often appear undifferentiated at neutral genetic markers, despite often extensive environmental and phenotypic variation. We examined genome-wide genetic differentiation and DNA methylation between three interconnected regions and one insular population of Canada lynx (Lynx canadensis) to determine if epigenetic modifications characterized climatic associations and functional molecular plasticity. Demographic approximations indicated divergence of Newfoundland during the last glaciation, while cryptic epigenetic structure identified putatively functional differentiation that might explain island dwarfism. Our study suggests that DNA methylation is a useful marker for differentiating wild populations, particularly when faced with functional plasticity and low genetic differentiation.
Reducing blood culture contamination using an initial specimen diversion device
Authors: Zimmerman Frederic S. , Assous Marc V. , Zevin Shoshana , Wiener-Well Yonit
Published: May 2018

False positive blood cultures result from contamination, consuming microbiological laboratory resources and causing unnecessary antibiotic treatment and lengthened hospitalizations. Skin sterilization has been shown to reduce contamination; however, bacteria do not only colonize the surface of human skin, but are also found in deeper tissues, requiring additional techniques to reduce contamination. An initial specimen diversion device diverts the initial 1-2 ml of blood so as to remove any potentially contaminated skin plug, thus potentially further reducing culture contamination. The device has been associated with a reduction in culture contamination over short study periods in certain populations. However, more study is needed to understand whether the effect continues over longer periods of time and in hospitalized patients. Thus, in this prospective, controlled pragmatic study, cultures were obtained from hospitalized patients using the initial specimen diversion device, with cultures taken using standard methods serving as control. In total, 671 blood cultures were obtained: 207 cultures were taken using an initial specimen diversion device, with 2 (1.0%) contaminated cultures and 464 cultures were taken without the device, with 24 (5.2%) contaminated cultures (p < 0.008). No significant difference was shown in the rate of true positive cultures. Thus, use of a diversion device was associated with reduced culture contamination in hospitalized patients over a six month period without concomitant reduction in true positive cultures. This intervention may result in a reduction in costs, antibiotic use and duration of hospitalization.
Structural variability and functional association in the epiphytic bacteria assemblies of freshwater macrophytes (Myriophyllum spicatum)
Authors: Xian Ling , Wan Tao , Cao Yu , Sun Junyao , Wu Ting , Zhao Suting , Apudo Andrew Apudo , Li Wei , Liu Fan
Published: May 2018

The underlying principles influencing bacteria community assembly have long been of interest in the field of microbial ecology. Environmental heterogeneity is believed to be important in controlling the uniqueness and variability of communities. However, little is known about the influence of the host macrophytes on epiphytic bacteria assembly processe. Here, we produced two contrasting artificial water environments (eutrophic and oligotrophic) for reciprocal transplant experiment ofMyriophyllum spicatum, to recover the colonization of epiphytic bacteria accompanied with plants growth. Comparative analysis addressed a higher species diversity in epiphytic bacteria than in bacterioplankton, and the highest microbiome richness in sediment. Our data revealed that the organization of epiphytic bacterial community was interfered by both plant status (i.e. branch number, net photosynthesis rate etc.) and water bodies (i.e. total phosphate, total nitrogen, pH etc.) while plant status effected the assembly in priority to water. 16S rRNA sequencing further indicated that the epiphytic assemblies were motivated by functionalization and interplay with hosts as a whole. The results complemented new evidences for the ‘lottery process’ in the epiphytic bacteria assembly traits and shed insights into the assembly patterns referring to functional adaptation across epiphytic bacteria and macrophytes.

Importance

A robust understanding of inter-adaptation between microbiome and the host plants have been established basing on vast majority of researches. However, great efforts were made mostly on rhizosphere microbiome. By contrast, referring to another representative group, macrophytes who composed of the freshwater ecosystem were relatively less investigated on such issue. Our study pioneered the experimental operation to interrogate the triadic relationship among macrophytes, epiphytic bacteria and water body. The research present here showed significant exemplar on discussion of plant associate bacteria adaptation taking account of host colonization as well as the epiphytes. The results expand the hypotheses of bacteria assembly principle and provides potential leads on understanding of plant - microbe interactions.
TrackingBorrelia afzeliifrom infectedIxodes ricinusnymphs to mice suggests a direct ‘gut-to-mouth’ route of Lyme disease transmission
Authors: Pospisilova Tereza , Urbanova Veronika , Hes Ondrej , Kopacek Petr , Hajdusek Ondrej , Sima Radek
Published: May 2018

Quantitative tracking ofBorrelia afzeliihas shown that its transmission cycle differs from the salivary route ofB. burgdorferitransmission byIxodes scapularis.Borrelia afzeliiare abundant in the guts of unfedIxodes ricinusnymphs and their numbers continuously decrease during feeding. In contrast, spirochetes are not present in the salivary glands.Borrelia afzeliitransmission starts during the early stages of feeding, spirochetes could be detected in murine skin within 1 day of tick attachment. Tick saliva is not essential forB. afzeliiinfectivity, the main requirement for successful host colonization being a change in outer surface protein expression that occurs in the tick gut during feeding. Spirochetes in vertebrate mode are able to survive within the host even if the tick is not present. On the basis of our data we propose that a direct ‘gut-to-mouth’ route of infection appears to be the main route ofB. afzeliitransmission.

Importance

Lyme borreliosis is the most common vector-borne disease in the USA and Europe. The disease is caused by theBorreliaspirochetes and is transmitted throughIxodesticks. A better understanding of howBorreliaspirochetes are transmitted is crucial for development of efficient vaccines for preventing Lyme borreliosis. Here we present that the transmission of EuropeanB. afzeliispirochetes byI. ricinusticks significantly differs from the model transmission cycle described for AmericanB. burgdorferi/I. scapularis. We suggest thatB. afzeliiis not transmitted via salivary glands but most likely through the ‘midgut to mouthpart’ route. We further demonstrate that tick saliva is not important forB. afzeliitransmission and infectivity. Therefore, we support early studies by Willy Burgdorfer, who proposed thatBorreliatransmission occurs by regurgitation of infected gut contents. Our findings collectively point to theBorrelia-tick midgut interface as the correct target in our endeavours to combat Lyme borreliosis.
DeepRibo: precise gene annotation of prokaryotes using deep learning and ribosome profiling data
Authors: Clauwaerts Jim , Menschaert Gerben , Waegeman Willem
Published: May 2018

Annotation of gene expression in prokaryotes often finds itself corrected due to small variations of the annotated gene regions observed between different (sub-species. It has become apparent that traditional sequence alignment algorithms, used for the curation of genomes, are not able to map the full complexity of the genomic landscape. We present DeepRibo, a novel neural network applying ribosome profiling data that shows to be a precise tool for the delineation and annotation of expressed genes in prokaryotes. The neural network combines recurrent memory cells and convolutional layers, adapting the information gained from both the high-throughput ribosome profiling data and Shine-Dalgarno region into one model. DeepRibo is designed as a single model trained on a variety of ribosome profiling experiments, and is therefore evaluated on independent datasets. Through extensive validation of the model, including the use of multiple species sequence similarity and mass spectrometry, the effectiveness of the model is highlighted.
Iodine status of children and Knowledge, Attitude, Practice of Iodised salt use in a remote community in Kerema district, Gulf province, Papua New Guinea
Authors: Goris Janny M , Temple Victor J , Zomerdijk Nienke , Codling Karen
Published: May 2018

Iodine deficiency is the single most common cause of preventable mental impairment in communities with suboptimal iodine intake. Objective of the present study was to assess in more detail the iodine status and knowledge, attitudes and practice (KAP) relating to use of iodised salt in a remote community in Kotidanga area, Kerema district, Gulf province, Papua New Guinea. This prospective school and community based cross-sectional study was carried out in 2017. Simple random sampling was used to select schools. Multistage sampling was used to randomly select 291 children aged 6 to 12 years. Salt samples were collected for analysis from children’s households as well as a single urine sample of selected children. Salt iodine content and Urinary iodine concentration (UIC) were analysed. A semi-structured FAO questionnaire was used to assess KAP of three different community groups. Only 64% of households had salt on the day of data collection. Mean iodine content in household salt samples was 29.0 ± 19.1 ppm. Iodine content was below 30.0 ppm in 54.8% and below 15.0 ppm in 31.2% of salt samples. Mean per capita discretionary intake of household salt was 2.9 ± 1.8 g/day. Median UIC was 25.5 μg/L and Interquartile Range was 15.0 to 47.5 μg/L; 75.9% (221/291) of the children had UIC below 50.0 μg/L, indicating moderate status iodine nutrition. Median UIC was 34.3μg/L for children in households with salt, compared to 15.5 μg/L for children in households without salt, indicating severe iodine deficiency in the latter group. The three community groups had limited knowledge about importance of using iodised salt and consequences of iodine deficiency on health outcomes. This remote community has limited access to adequately iodised household salt due to high cost, inappropriate packaging, storage and food preparation, resulting in iodine deficiency. Strategies to increase iodine intake are needed.
Correlations of objective and self-report assessment of physical activity in twins: insights from the AUTBACK study.
Authors: Soh Keng Yew , Pinheiro Marina B , Mackey Martin , Scurrah Katrina , Bauman Adrian , Leite Hercules Ribeiro , Ferreira Paulo
Published: May 2018

Aim: To investigate the influence of genetic and environmental factors on physical activity levels.
Methods: Data from 134 twins from Twins Research Australia, self-report and objective measures of physical activity were obtained by the International Physical Activity Questionnaire (IPAQ) (n = 110) and Actigraph (n = 120), respectively. Correlations were calculated for twin pairs stratified by zygosity (Monozygotic, MZ; Dizygotic, DZ) and using Spearman's correlation (rs)
Results: Within-pair correlations were usually higher in MZ for the Actigraph (rs ranging from 0.34 [0.0 to 0.57] to 0.48 [0.22 to 0.68]) compared to IPAQ (rs ranging from -0.15 [-0.44 to 0.17] to 0.52 [0.25 to 0.72]. Correlations in DZ were lower for the Actigraph (rs ranging from -0.03 [-0.55 to 0.51] to 0.16 [-0.41 to 0.64]) compared to IPAQ (rs ranging from -0.11 [-0.59 to 0.43] to 0.50 [-0.01 to 0.81]). Correlations between Actigraph and IPAQ for all individuals were small for sedentary vs sitting time (rs = 0.28) and vigorous physical activity (rs = 0.27), but moderate for total physical activity (rs = 0.35).
Conclusion: Within-family correlation of physical activity levels depends on the assessment, with less consistent results when its assessed by self-reported methods.
Nurtured by nature: Considering the role of environmental and parental legacies in coral ecological performance
Authors: Putnam Hollie M. , Ritson-Williams Raphael , Cruz Jolly Ann , Davidson Jennifer M. , Gates Ruth D.
Published: May 2018

The persistence of reef building corals is threatened by human-induced environmental change. Maintaining coral reefs into the future requires not only the survival of adults, but also the influx of recruits to promote genetic diversity and retain cover following adult mortality. Few studies examine the linkages among multiple life stages of corals, despite a growing knowledge of carryover effects in other systems. We provide a novel test of coral parental preconditioning to ocean acidification (OA) to better understand impacts on the processes of offspring recruitment and growth. Coral planulation was tracked for three months following adult exposure to high pCO2and offspring from the second month were reciprocally exposed to ambient and high pCO2. Offspring of parents exposed to high pCO2had greater settlement and survivorship immediately following release, retained survivorship benefits during one and six months of continued exposure, and further displayed growth benefits to at least one month post release. Enhanced performance of offspring from parents exposed to high conditions was maintained despite the survivorship in both treatments declining in continued exposure to OA. Preconditioning of the adults while they brood their larvae may provide a form of hormetic conditioning, or environmental priming that elicits stimulatory effects. Defining mechanisms of positive carryover effects, or positive trans-generational plasticity, is critical to better understanding ecological and evolutionary dynamics of corals under regimes of increasing environmental disturbance. Considering parental and environmental legacies in ecological and evolutionary projections may better account for coral reef response to the chronic stress regimes characteristic of climate change.
Mixed-cropping systems of different rice cultivars have grain yield and quality advantages over mono-cropping systems
Authors: Li Meijuan , Zhang Jiaen , Liu Shiwei , Ashraf Umair , Qiu Shuqing
Published: May 2018

Mixed-cropping system is a centuries-old cropping technique that is still widely practiced in the farmers’ field over the globe. Increased plant diversity enhances farmland biodiversity, which would improve grain yield and quality; however, the impacts of growing different rice cultivars simultaneously were rarely investigated. In present study, five popular rice cultivars were selected and ten mixture combinations were made according to the growth period, plant height, grain yield and quality, and pest and disease resistance. Seedlings of the five cultivars and ten mixture combinations (mixed-sowing of the seeds in an equal ratio, then mixed-transplanting and finally mixed-harvesting) were grown in plastic pots under greenhouse during the early and late growing seasons in 2016. Results showed that, compared with the corresponding mono-cropping systems, almost all combinations of the mixed-cropping systems have advantages in yield related traits and grain quality. Compared with the mono-cropping systems in the early and late growing seasons in 2016, mixed-cropping systems increased the number of spikelets per panicle, seed-setting rate, and grain weight per pot and harvest index by 19.52% and 5.77%, 8.53% and 4.41%, 8.31% and 4.61%, and 10.26% and 6.98%, respectively (paired t-test). In addition, mixed-cropping systems reduced chalky rice rate and chalkiness degree by 33.12% and 43.42% and by 30.11% and 48.13% in the early and late growing seasons, respectively (paired t-test). These results may be due to enhanced SPAD indexes and photosynthetic rates at physiology maturity in mixed-cropping systems. In general, it was found that mixed-cropping with different rice cultivars have potential for increasing grain yield and improving grain quality.
Optogenetic dissection of Rac1 and Cdc42 gradient shaping
Authors: De Beco S. , Vaidžiulytė K. , Manzi J. , Dalier F. , di Federico F. , Cornilleau G. , Dahan M. , Coppey M.
Published: May 2018

During migration, cells present a polarized activity that is aligned with the direction of motion. This cell polarity is established by an internal molecular circuitry, without the requirement of extracellular cues. At the heart of this circuitry, Rho GTPases spontaneously form spatial gradients that define the front and back of migrating cells. At the front of the cell, active Cdc42 forms a steep gradient whereas active Rac1 forms a more extended pattern peaking a few microns away from the cell tip. What are the mechanisms shaping these gradients, and what is the functional role of the shape of these gradients? Combining optogenetics and cell micopatterning, we show that Cdc42 and Rac1 gradients are set by spatial patterns of activators and deactivators and not directly by advection or diffusion mechanisms. Cdc42 simply follows the distribution of GEFs thanks to a uniform GAP activity, whereas Rac1 shaping requires the activity of an additional GAP, β2-chimaerin, which is sharply localized at the tip of the cell. We find that β2-chimaerin recruitment depends on feedbacks from Cdc42 and Rac1. Functionally, the extent -neither the slope nor the amplitude- of RhoGTPases gradients governs cell migration. A Cdc42 gradient with a short spatial extent is required to maximize directionality during cell migration while an extended Rac1 gradient controls the speed of the cell.
The Effects of Different Vibration Frequencies, Amplitudes and Contraction Levels on Lower Limb Muscles during Graded Isometric Contractions Superimposed on Whole Body Vibration Stimulation
Authors: Pujari Amit N. , Neilson Richard D. , Cardinale Marco
Published: May 2018

Background

Indirect vibration stimulation i.e. whole body vibration or upper limb vibration, has been suggested increasingly as an effective exercise intervention for sports and rehabilitation applications. However, there is a lack of evidence regarding the effects of whole body vibration (WBV) stimulation superimposed to graded isometric contractions superimposed on. For this scope, we investigated the effects of WBV superimposed to graded isometric contractions in the lower limbs on muscle activation. We also assessed the agonist-antagonist co-activation during this type of exercise.

Twelve healthy volunteers were exposed to WBV superimposed to graded isometric contractions, at 20, 40, 60, 80 and 100% of the maximum voluntary contractions (V) or just isometric contractions performed on a custom designed horizontal leg press Control (C). Tested stimulation consisted of 30Hzand 50Hz frequencies and 0.5mm and 1.5mm amplitudes. Surface electromyographic activity of Vastus Lateralis (VL), Vastus Medialis (VM) and Biceps Femoris (BF) were measured during V and C conditions. Co-contraction activity of agonist-antagonist muscles was also quantified. The trials were performed in random order.

Results

Both the prime mover, (VL) and the antagonist, (BF) displayed significantly higher (P < 0.05) EMG activity with the V than the C condition. For both the VL and BF, the increase in mean EMGrms values depended on the frequency, amplitude and muscle contraction level with 50Hz-0.5mm stimulation inducing the largest neuromuscular activity. 50Hz-0.5mm V condition also led to co-activation ratios significantly (P< 0.05) higher at 40, 80 and 100% of MVC than the C condition.

Conclusions

Our results show that the isometric contraction superimposed on vibration stimulation leads to higher neuromuscular activity compared to isometric contraction alone in the lower limbs. Compared to the control condition, the vibratory stimulation leads to higher agonist-antagonist co-activation of the muscles around the knee joint in all vibration conditions and effort levels. The combination of vibration magnitude (frequency and amplitude) and the level of muscle contraction affect neuromuscular activity rather than vibration frequency alone. Results of this study suggest that more parameters need to be taken into consideration when designing vibration exercise programs for sports and rehabilitation purposes.
Antagonizing the corticotropin releasing hormone receptor 1 with antalarmin reduces the progression of endometriosis
Authors: Torres-Reverón Annelyn , Rivera-Lopez Leslie L. , Flores Idhaliz , Appleyard Caroline B.
Published: May 2018

Endometriosis is a disorder in which endometrial tissue is found outside the uterus causing pain, infertility and stress. Finding an effective and long-term treatment for endometriosis still remains one of the most significant challenges in the field. Corticotropin releasing hormone (CRH) is one of the main signaling peptides within the hypothalamic pituitary adrenal (HPA) axis released in response to stress. CRH can affect nervous and visceral tissues such as the uterus and gut via activation of two types of CRH receptors: CRHR1 and CRHR2. Our aim was to determine if blocking CRHR1 with antalarmin will reduce endometriosis progression. First, we induced endometriosis in female rats by suturing uterine horn tissue next to the intestinal mesentery and allowed to progress for 7 days. We determined that after 7 days, there was a significant increase in CRHR1 within endometriotic vesicles as compared to normal uterus. A second group of rats received endometriosis but also antalarmin (20 mg/kg, i.p.) during the first 7 days after surgery. As separate group of sham surgery rats served as controls. Endometriosis was allowed to progress until 60 days after surgery. At time of sacrifice, rats were tested for anxiety behaviors and endometriotic vesicles, and uterus were collected. Rats with endometriosis that received antalarmin significantly reduced the size (67% decrease) and number (30% decrease) of endometriotic vesicles. Antalarmin also prevented the increase in CRH and CRHR1 within endometriotic vesicles but not of glucocorticoid receptor. Behaviorally, endometriosis increased anxiety in the zero-maze test but antalarmin did not modify it. Our data provides the first demonstration for the effective use on CRHR1 antagonist for the treatment of endometriosis with promising effects for long-term therapy of this debilitating disease.
Rethinking artisan entrepreneurship in a small island
Authors: Arias Ricardo Alonzo Cortez , Cruz Allan Discua
Published: May 2018

Purpose

There is a growing interest in artisan entrepreneurs around the world. Scholars are increasingly interested in how artisan enterprises use tourism in a resource-constrained resources. Based on the concept of artisan chocolate entrepreneur, the purpose of this paper is to examine the phenomenon of artisanal chocolate making in a small island with limited resources yet influenced by increased tourism.

Design/methodology/approach

Artisan enterprises are considered relevant in developing countries and their creation merits further attention. This study examines artisan enterprises using in-depth interviews, case studies, and an interpretative approach. The approach enables examining how artisan chocolate enterprises use tourism to develop their businesses in a context characterized by limited resources.

Findings

The findings show that artisan entrepreneurs are encouraged to start and develop enterprises due to lifestyle choices. The findings reveal a connection between artisan chocolatiers developing place-bound features to address a growing demand of tourists’ expectation for authentic and local products. The approach of artisan entrepreneurs in such conditions can be explained through entrepreneurial bricolage.

Originality/value

This study contributes to the literature on the initial stages of artisan enterprises particularly in resource-constrained environments influenced by tourism. More specifically, the study provides evidence of the relevance of tourism for artisanal enterprise emergence, which is a relatively overlooked area in tourism and artisanal studies in developing countries. The study highlights the key place bound features that artisanal chocolate entrepreneurs associate to their products based on tourists’ demand for authentic and local products.
Social media adoption and its impact on firm performance: the case of the UAE
Authors: Ahmad Syed Zamberi , Abu Bakar Abdul Rahim , Ahmad Norita
Published: May 2018

Purpose

Through social media technologies, small and medium-sized enterprises (SMEs) can communicate information and respond to competitors with minimal cost. The ability to share and access information can affect SMEs’ performance, but there is little research on the link between SMEs’ social media adoption and their performance. The purpose of this paper is to present a quantitative survey to explore factors that influenced social media adoption by SMEs in the United Arab Emirates (UAE), and its impact on performance.

Design/methodology/approach

The study used a multi-perspective framework combining technological, organizational and environmental elements affecting SMEs. Survey questionnaires were used to collect data from a random sample of SMEs operating in the UAE. Using partial least squares and structural equation modeling techniques, 144 responses were analyzed.

Findings

Social media adoption had no effect on SMEs’ performance. These findings could help managers and decision makers in the SME sector to try to keep pace with research on social media innovations, and enable them to benefit from social commerce as it becomes more ubiquitous.

Research limitations/implications

This has implications for social media experts and anyone wishing to encourage social media use by SMEs.

Originality/value

The study developed a suitable multi-perspective framework covering various factors that may affect social media use. It also tested the framework empirically on a sample of SMEs from the UAE.
Peer assessment through digital storytelling: experiences of pre-service IT teachers
Authors: Tatli Zeynep , Uğur Nursel , Çakiroğlu Ünal
Published: May 2018

Purpose

The purpose of this paper is to reveal the contribution of the digital storytelling to the peer assessments experiences of pre-service teachers within the teaching practices.

Design/methodology/approach

The study is carried out as a special case study. Both qualitative and quantitative data gathering tools were used together to investigate a special case in depth (Yıldırım and Şimşek, 2011; Çepni, 2007). In this study, the case investigated was the process whereby the senior year pre-service teachers enrolled in the faculty of education provided assessments of themselves and their peers through the teaching practice course, using digital storytelling. The contributions of the assessment method employed, in the experiences and personal development of the pre-service teachers, were investigated through interviews with pre-service teachers involved.

Findings

The results suggested that pre-service teachers’ perspectives were quite positive toward the use of digital storytelling for peer assessment in their teaching practices. The prominent contributions were: they caused easily tolerate personally as they did not take a direct form, and that they considered peer assessment through digital storytelling as an alternative means of assessment to effectively reflect the process. Receiving more detailed feedback about their classroom experiences and their teaching skills was helpful for pre-service IT teachers. Suggestions due to the findings were also included.

Originality/value

In the study, peer assessment digital stories in the teaching practice courses offers the benefits of confidence with, different perspectives, satisfaction, and objectivity. These benefits can help pre-service teachers to focus on shortcomings regarding their teaching experiences, and take care for the correction. Further studies can be provided about the digital storytelling processes in various assessment processes of the instructions to reveal the potential of digital narratives in other domains as well.
Explaining the emergence of team agility: a complex adaptive systems perspective
Authors: Werder Karl , Maedche Alexander
Published: May 2018

Purpose

Agile software development helps software producing organizations to respond to manifold challenges. While prior research focused on agility as a project or process phenomenon, the authors suggest that agility is an emergent phenomenon on the team level. The paper aims to discuss this issue.

Design/methodology/approach

Using the theory of complex adaptive systems (CASs), the study captures the multiple influencing levels of software development teams (SDTs) and their interplay with self-organization and emergence. The authors investigate three agile SDTs in different contextual environments that participate with four or more different roles each.

Findings

The results suggest self-organization as a central process when understanding team agility. While contextual factors often provide restriction on self-organization, they can help the team to enhance its autonomy.

Research limitations/implications

The theoretical contributions result from the development and test of theory grounded propositions and the investigation of mature agile development teams.

Practical implications

The findings help practitioners to improve the cost-effectiveness ratio of their team’s operations.

Originality/value

The study provides empirical evidence for the emergence of team agility in agile SDTs. Using the lens of CAS, the study suggests the importance of the team’s autonomy.
Benefits realisation from IT-enabled innovation
Authors: Waring Teresa , Casey Rebecca , Robson Andrew
Published: May 2018

Purpose

The purpose of this paper is to address the call for more public sector empirical studies on benefits realisation (BR), to contribute to the literature on BR as a dynamic capability (DC) within the context of IT-enabled innovation in a public sector context and to highlight the challenges facing organisations if they adopt a BR competence and capability framework.

Design/methodology/approach

The empirical research conducted within this paper is an exploratory survey. Exploratory surveys are particularly useful when investigating a little known phenomenon and can help to uncover or provide preliminary evidence of association among concepts. This survey was a census of all National Health Service acute hospital trusts in England.

Findings

The study indicates that most hospitals that participated in the survey have a basic approach to BR and have yet to develop a more mature approach that would provide the strong micro-foundations of a BR capability.

Research limitations/implications

The BR framework that has been the basis of the survey is interesting in terms of its components but is limited with regards to the micro-foundations of a benefits realisation capability within an organisation. The research suggests that organisations in the public sector need to focus much more on staff development and recruitment in the area of BR to ensure that they have the appropriate skills sets for a rapidly changing environment.

Originality/value

The paper proposes a framework for BR capabilities and IT-enabled change, and suggests that although the concept of maturity is valuable when considering the micro-foundations of BR, DCs change and respond to stimuli within the external and internal environment and must be renewed and refreshed regularly.
Institutions, human capital and entrepreneurial orientation: implications for growth policy
Authors: Mthanti Thanti , Ojah Kalu
Published: May 2018

Purpose

The purpose of this paper is to establish a more robust empirical support for the long established postulation by Adam Smith and Joseph Schumpeter that human capital and institutions enable Schumpeterian entrepreneurship, which, in turn, facilitates economic growth.

Design/methodology/approach

Adopting entrepreneurial orientation (EO) (i.e. innovativeness, proactiveness and risk taking; Mthanti and Ojah, 2017, Research Policy, 46:4, pp. 724-739) as the measure of Schumpeterian entrepreneurship at the macro-level, and using a sample of 93 countries, over 1980-2008, the authors employ system Generalised Method of Moments to investigate institutions and human capital as possible determinants of Schumpeterian entrepreneurship (EO).

Findings

The authors find that the human capital-EO nexus is robust across economic development levels. However, there is a cross-country variation in the institutions-EO nexus. In line with theoretical predictions, institutions indeed drive EO in middle-to-high-income countries. However, in low-income countries, building institutions in order to foster EO yields perverse outcomes, which, for us and especially based on deeper analysis, suggest that improving the quality of institutions may not be a necessary precondition for EO/growth policy in low-income countries. Furthermore, the authors find that EO is a highly persistent series, with self-reinforcing network effects, i.e. lofty EO behaviour encourages more lofty EO behaviour.

Research limitations/implications

Drivers of macro EO are erroneously taken as of growth. This empirical analysis corrects the sequencing.

Practical implications

Policy practice must acknowledge macro-EO importantly has both direct and indirect growth effects.

Originality/value

This study is the first to empirically test the theoretical sequence between drivers of growth/EO and economic growth.
The energetic consequences of habitat structure for forest stream salmonids
Authors: Naman Sean M. , Rosenfeld Jordan S. , Kiffney Peter M. , Richardson John S.
Published: May 2018

Increasing habitat availability (i.e. habitat suitable for occupancy) is often assumed to elevate the abundance or production of mobile consumers; however, this relationship is often nonlinear (threshold or unimodal). Identifying the mechanisms underlying these nonlinearities is essential for predicting the ecological impacts of habitat change, yet the functional forms and ultimate causation of consumer‐habitat relationships are often poorly understood.

Nonlinear effects of habitat on animal abundance may manifest through physical constraints on foraging that restrict consumers from accessing their resources. Subsequent spatial incongruence between consumers and resources should lead to unimodal or saturating effects of habitat availability on consumer production if increasing the area of habitat suitable for consumer occupancy comes at the expense of habitats that generate resources. However, the shape of this relationship could be sensitive to cross‐ecosystem prey subsidies, which may be unrelated to recipient habitat structure and result in more linear habitat effects on consumer production.

We investigated habitat‐production relationships for juveniles of stream‐rearing Pacific salmon and trout (Oncorhynchus spp.), which typically forage in low‐velocity pool habitats, while their prey (drifting benthic invertebrates) are produced upstream in high‐velocity riffles. However, juvenile salmonids also consume subsidies of terrestrial invertebrates that may be independent of pool‐riffle structure.

We measured salmonid biomass production in 13 experimental enclosures each containing a downstream pool and upstream riffle, spanning a gradient of relative pool area (14%–80% pool). Increasing pool relative to riffle habitat area decreased prey abundance, leading to a nonlinear saturating effect on fish production. We then used bioenergetics model simulations to examine how the relationship between pool area and salmonid biomass is affected by varying levels of terrestrial subsidy. Simulations indicated that increasing terrestrial prey inputs linearized the effect of habitat availability on salmonid biomass, while decreasing terrestrial inputs exaggerated a “hump‐shaped” effect.

Our results imply that nonlinear effects of habitat availability on consumer production can arise from trade‐offs between habitat suitable for consumer occupancy and habitat that generates prey. However, cross‐ecosystem prey subsidies can effectively decouple this trade‐off and modify consumer‐habitat relationships in recipient systems.
Gender Equality as a Closed Case: A Survey among the Members of the 2015 Danish Parliament
Authors: Dahlerup Drude
Published: May 2018

Despite almost unanimous adherence to the principle of gender equality in contemporary Denmark, a society with a long historical record of gender equality policies and almost 40 percent women in parliament, are there still divergences to be found among the members of parliament concerning gender equality principles and policies? This article argues that in order to identify underlying cleavages it is necessary to pose fundamental questions that go beyond the day‐to‐day disagreements on policy issues. Based on a new survey of the members of the Danish parliament, this study finds that the support for gender equality is not just a matter of lip service insofar as few MPs hold traditionalist views on women. However, the study reveals conflicting perceptions, left‐right cleavages and gender gaps, sometimes also within the parties. A new discourse is identified, supported by a large minority that includes all of the male MPs from the four right‐wing parties; this minority considers gender equality to be a ‘closed case’ – that is, as having by and large been achieved. This may provide clues to the puzzle of the stagnation in gender equality reforms in spite of the general support for ‘gender equality’. The article discusses the possible connection between the ‘closed case’ discourse, present neoliberal trends in society and the recent construction of gender equality as an ‘intrinsic Danish value’ – an argument familiar in other countries with a harsh debate over immigration.
Demolishing the Present to Sell off the Future? The Emergence of ‘Financialized Municipal Entrepreneurialism’ in London
Authors: Beswick Joe , Penny Joe
Published: May 2018

This article introduces a new mode of urban entrepreneurialism in London through a study of the state‐executed, speculative development and financialization of public land. In response to an intensifying housing crisis and austerity‐imposed fiscal constraints, municipalities in London are devising entrepreneurial solutions to deliver more housing. Among these ‘solutions’ can be found the early signs of the state‐executed financialization of public housing in the UK with the use of speculative council‐owned special purpose vehicles (SPVs) that replace existing public housing stock with mixed‐tenure developments, creating ambiguous public/private tenancies that function as homes and the basis for liquid financial assets. Drawing together parallel literatures on the financialization of urban governance and housing, and combining these with original empirical research, we situate these developments in contrast to earlier modes of governance, identifying a distinct mode of entrepreneurial governance in London: financialized municipal entrepreneurialism. The local state is no longer merely the enabler—limited to providing strategic oversight of the private sector—but financializes its practice in a reimagined commercialized interventionism, as property speculator. This article concludes that while the architects of this new mode of entrepreneurialism extol the increased capacity and control it provides, any such gains must be set against longer‐term financial, democratic and political risks.
Melitz Meets Milk: The Impact of Quota Abolition on EU Dairy Export Competitiveness
Authors: Philippidis George , Waschik Robert
Published: May 2018

Previous studies of EU milk quota abolition usually assume perfect competition (PC) in the dairy industry, despite evidence to the contrary. We use a global computable general equilibrium framework with an imperfectly competitive (IC) model variant, which offers insights into structural change (i.e. scale of output, firm entry/exit) and varietal diversity in the dairy industry. A heterogeneous‐firm Melitz extension enriches our analysis by endogenising the decision‐making process of domestic firms when exporting (or not) to specific foreign markets. The results from a PC CGE model variant are found to be consistent with respected market outlooks and official data. Furthermore, PC and IC variants generate broadly similar trends – a result corroborated in a previous study of Italian dairy firms. Our IC model prediction of a ‘shakeout’ among EU dairy firms is tentatively supported by actual observations. Finally, as an industry characterised by significant product innovation, increased extra‐EU export orientation by remaining dairy firms increases varietal choice, which further boosts EU dairy exports compared with the PC model variant.
Optimal Design of Agri‐environmental Schemes under Asymmetric Information for Improving Farmland Biodiversity
Authors: Gómez‐Limón José A. , Gutiérrez‐Martín Carlos , Villanueva Anastasio J.
Published: May 2018

Information asymmetry is one of the main obstacles to the effective design and implementation of agri‐environmental schemes (AES). The literature has generally addressed this issue through the use of principal‐agent models (PAM). We develop a PAM to support optimal design of a new AES for improving farmland biodiversity. We use the results of choice experiments to assess both the costs incurred by the agent for the provision of biodiversity and the resulting social benefits. We also make a number of novel contributions such as the inclusion of a non‐linear non‐compliance detection curve, a sensitivity analysis to identify which parameter estimates have a critical impact on PAM results, and analysis of the efficiency of different sanction scenarios. The results suggest that: (i) the second‐best solutions differ significantly from the optimal solutions attainable with perfect information, with farmers being strongly over‐compensated for the extra costs associated with improved biodiversity; (ii) monitoring levels should be higher; (iii) the sanction system should be tougher. Sensitivity analysis shows the need for accurate estimates of the marginal cost of public funds and the costs and benefits associated with the public goods, which represent the key parameters determining PAM results.