bluuebunny/crossref_metadata_2025 huggingface dataset:
Gas in the Inferior Mesenteric Vein – successful non operative management of a rare complication of diverticulitis
Authors:   1Department of General Surgery, Redland Hospital, Cleveland, Queensland, Australia 2Department of General Surgery, Hervey Bay Hospital, Urraween, Queensland, Australia
Published: August 2021

Septic phlebitis (also known as pyelephlebitis) because of diverticulitis is a rare but important complication. Many previous cases have mandated urgent surgical management for fear of further deterioration. This case report details one of the first cases where septic phlebitis was successfully managed conservatively, and details important clinical lessons clinicians should be aware of.
Myxedema coma in COVID-19
Authors: Yuichi Takashi , Daiji Kawanami
Published: August 2021

SARS-CoV-2 infection is associated with thyroid disorders. It has been reported that myxedema coma (MC) can be complicated with COVID-19. COVID-19-related thyroid disorders consist of a broad spectrum of thyroid dysfunction, from thyrotoxicosis to decompensated hypothyroidism. It is possible that both primary and central thyroid disorders are induced by COVID-19 due to systemic inflammatory and immune responses. We experienced two cases in which patients with COVID-19 developed MC with central hypothyroidism. It is likely that MC affected the severity of COVID-19. It is necessary to consider the existence of MC during SARS-CoV-2 infection. We propose the potential mechanisms.
Analysis of the nutritional status of adolescents in Pará, Brazil, from 2010 to 2019
Authors: De Sousa Costa Ana Gabriela , De Araujo Sousa Randerson José , Amaral Filgueiras Ligia
Published: August 2021

Objective: to analyze the nutritional status of adolescents in the status state of Pará, Brazil, in order to observe the trends in the Height x Age and BMI x Age indexes. Material and Methods: it was a quantitative, retrospective and cross-sectional study from 2010 to 2019. The female and male sex were evaluated in each nutritional status index “Height x Age” and “BMI x Age”. The collected data were organized in Microsoft Excel 2010 software and statistics was performed in the Action Stat 3.7 program. A theoretical framework was adopted with complete scientific articles published in the BVS, SciELO, MEDLINE, LILACS databases and institutional documents. The ethics committee's assessment was not necessary. Results: in “Height x Age”, a total of 132,114 adolescents were registered and the female gender prevailed (65.8%), normality in the distribution of data was observed and a difference was noted in the category “Suitable for age”, which registered more notifications (80.9%). In the "BMI x Age", 132,204 were reported, a normal distribution was found, but there was a statistical difference between the sexes in the categories: "overweight", "obesity", "severe obesity" and "eutrophy", which represented the largest percentage (73.4%). Conclusion: the population is mostly female, and the distribution of records is heterogeneous. Both sexes were shown to be of adequate height for their age and eutrophic. However, it was noticed that the nutritional scenario is changing, which may lead, in the future, to public health problems, such as the increase in the number of patients with chronic non-communicable diseases.
Mortalidad relacionada con tuberculosis en mayores de 50 años en el departamento de Caldas (Colombia) 2010 a 2017
Authors: Gomez Fernando , Osorio Carmenza , Aguilar Carlos Darío
Published: August 2021

Objetivo: describir las características de los pacientes mayores de 50 años que murieron debido a tuberculosis en Caldas (Colombia) durante los años 2010-2017 y comparar dos grupos: 50-69 años y 70 años y más. Previamente se ha demostrado la diferencia en los perfiles de los casos de muertes debido a tuberculosis tanto como causa básica y como causa asociada, especialmente relacionada con la edad. Materiales y métodos: estudio descriptivo de muertes por TB reportadas en la base de datos del Sistema Nacional de Vigilancia en Salud Pública –SIVIGILA-. Se realizó un análisis bivariado. Resultados: se identificaron 119 muertes de las cuales 61% fueron hombres, 79 (66%) fueron causadas directamente por TB y como causas asociadas se encontraron secuelas de TB, enfermedad respiratoria crónica y VIH. No se encontraron diferencias estadísticas entre los grupos respecto a la causa de muerte. Sin embargo, en el grupo más joven fueron hombres, solteros, agricultores con menos de 5 años de escolaridad mientras en el grupo mayor fueron mujeres, amas de casa, casadas, con bajo nivel educativo. Conclusión: se encuentran diferencias en la mortalidad por tuberculosis debidas a la edad que deben ser tenidas en cuenta al momento de evaluar pacientes y al diseñar programas de prevención y tratamiento.
Homo Faber
Authors: González González Miguel Alberto
Published: August 2021

Sólo el homo faber se comporta como señor y amo de toda la tierra. Arendt (2012, p. 168). La condición humana.

 

En lo  ordinario o refinado, el faber dedica su ingenio a construir, a elaborar artefactos para su entorno y, como no, en repetidas ocasiones a destruir la  naturaleza, al sentirse señor de su espacio, al creerse amo del universo le lleva a comportarse en rasgos devastadores.
Planteamiento del problema de investigación en educación: algunas orientaciones para profesores que investigan en el aula
Authors: Pineda Ballesteros Eliécer , Lizcano Dallos Adriana Rocío , Parra Valencia Jorge Andrick
Published: August 2021

Este artículo presenta una serie de reflexiones relacionadas con el planteamiento del problema de investigación en el aula, realizadas durante el año 2019, en el campo de la investigación en tecnología educativa, a partir de la racionalización de la práctica académica y tutorial en trabajo de grado con estudiantes de un programa de maestría virtual en tecnología aplicada a la educación, de la Universidad de Santander. Se usó el método de revisión sistematizada de la literatura, desde una perspectiva cualitativa, tomando en cuenta palabras clave de búsqueda relacionadas con el planteamiento del problema de investigación en educación; una vez procesados los documentos obtenidos y seleccionados, se redactaron los principales hallazgos. Se confirma que la formulación del problema es la parte más crítica del proceso de investigación y se encuentra que para ser exitosos en el planteamiento de un problema de investigación es útil partir del reconocimiento de una situación problemática.
Literasi dan Pendampingan Skrining Kesehatan Sistem Pernafasan Dalam Upaya Meningkatkan Program Gerakan Masyarakat Sehat
Authors: Zuriati  , Nani Asna Dewi  , Erika Lubis  , Pramestiyani Mustika , Sondang Manurung
Published: August 2021

Tuberkulosis paru (TB paru) adalah penyakit menular yang disebabkan bakteri mycobacterium tuberculosis. The World Health Organization (WHO) melaporkan Indonesia menduduki posisi ketiga dengan kasus  TB tertinggi di dunia dan merupakan negara penyumbang 60% dari seluruh kasus TB dunia. Upaya menurunkan kasus TB adalah melalui suatu literasi yang baik pada tentang sistem pernafasan. Tenaga kesehatan berusaha mengedukasi masyarakat dengan skrining. Pelayanan Keperawatan merupakan ujung tombak dalam pelayanan asuhan kepada pasien, tenaga kesehatan merupakan garda depan yang melayani masyarakat, terlebih pada masa pandemi COVID 19 sehingga berusaha memberikan pendampingan dan skrining kesehatan pada sistem pernafasan yang selaras dengan program Gerakan Masyarakat Sehat (Germas). Metode yang digunakan adalah ceramah dengan tatap muka yang diikuti oleh kader Kampung Cililitan berjumlah 15 orang. Hasil menunjukkan bahwa pengetahuan kader dengan kriteria baik naik dari 15,3% menjadi 90,6%. Kegiatan upaya literasi dan pendampingan skrining kesehatan sistem pernafasan meningkatkan pengetahuan kader dalam upaya program gerakan masyarakat sehat.
IBN TAIMIYAH�S VIEW ON GOVERNMENT INTERVENTION IN PRICING
Authors: Mujahidin Ali , Astuti Rika Pristian Fitri , Ningrum Ifa Khoiria
Published: August 2021

This study is a literature review with the normative approach. To achieve the desired objectives, the authors collected data consisting of primary and secondary data. The data obtained through the previous discussion of some theses, books, websites, supported by guidelines of the Qur�an and Al-Hadith. In gathering the data, the researcher uses the method of a documentary, and with the way the method of indirect observation, by visiting the library in search of data. The result of this research that Ibn Taimiyyah had two views in pricing, the first is valid pricing, second is invalid pricing. And valid pricing can be done by the government to stabilize the economic condition which is called intervention. The goal of intervention is to ensure social justice and prosperity of society. Intervention mechanisms are divided into two, namely direct and indirect. Direct intervention in the form of Al-Hisbah, the character of the institution as a corporate planner, set the market mechanism that is not fair. Besides, in the particular circumstances that required the intervention price, for example when there was war and famine, so all the high-priced goods, or when there was speculation in the market, which requires the seller to sell goods, or when there was speculation in the market, which requires the seller to sell goods with high price levels. While the indirect intervention was implemented in the educational problems and the fulfillment of public facilities such as transport and communication.
Фармакокинетика и тканевое распределение коэнзима Q10 при внутривенном введении в окисленной и восстановленной формах
Authors: Каленикова Елена Игоревна , Городецкая Евгения Ароновна , Оболенская Ольга Николаевна , Шаповал Натьлья Сергеевна , Макаров Валерий Геннадьевич , Медведев Олег Стефанович
Published: August 2021

Препараты, содержащие коэнзим Q10 (CoQ10) в окисленной (убихинон) или восстановленной (убихинол) формах, применяются для лечения заболеваний, сопряженных с окислительно-восстановительным дисбалансом, и предназначены только для приема внутрь. В связи с его низкой биодоступностью наиболее полно раскрыть терапевтический потенциал CoQ10 могли бы его парентеральные лекарственные формы. Цель исследования — сравнение фармакокинетики и тканевого распределения CoQ10 при внутривенном введении новых лекарственных форм убихинона и убихинола. Препараты (1 % водные растворы, аналогичные по составу вспомогательных веществ) вводили крысам однократно внутривенно (30 мг/кг). Отбор проб крови и образцов миокарда, мозга, печени и почек производили в течение 8 сут после введения, используя по 5 крыс на каждую временную точку. Содержание CoQ10 определяли методом ВЭЖХ-ЭХ и рассчитывали AUC и Clt. Показано, что, несмотря на различия убихинола и убихинона по величине общего клиренса, пополнение тканевого содержания CoQ10 в отдельных органах происходит одинаково успешно, что предполагает их равную эффективность при внутривенном введении.
Синтез и фармакологические свойства азоконъюгата эритропоэтина β с полиэтиленгликолем
Authors: Шереметьев Сергей Викторович , Лоншаков Дмитрий Владимирович , Белослудцева Елена Михайловна , Борисова Ольга Васильевна , Сидорова Анна Владимировна , Катлинский Антон Викентьевич
Published: August 2021

С целью поиска новых лекарственных средств на основе эритропоэтина β, для импортозамещения препарата Мирцера на территории Российской Федерации, был синтезирован конъюгат данного белка с линейным метоксиполиэтиленгликолем с молекулярной массой 30 кДа, в котором в качестве спейсера между полиэтиленгликолевым и белковыми фрагментами молекулы используется азогруппа. Эритропоэтическая активность синтезированного конъюгата, параметры его фармакокинетики у мышей линии CBA были сходными с таковыми для препарата Мирцера. На основе рассчитанных фармакокинетических параметров показана биоэквивалентность предложенного азоконъюгата препарату Мирцера у мышей.
Фотогенерированный йод для определения активных фармацевтических ингредиентов препарата «Тетралгин»
Authors: Турусова Елена В. , Насакин Олег Евгеньевич
Published: August 2021

Разработана методика ускоренного определения активных фармацевтических субстанций (АФС) препарата «Тетралгин», основанная на предварительном экстракционном разделении компонентов, дальнейшем получении водных извлечений и их вольтамперометрическом титровании раствором фотогенерированого йода, полученного в результате облучения вспомогательного раствора, содержащего йодид калия, смесь сенсибилизаторов (эозинат натрия:флуоресцеин:аурамин в молярном соотношении 1:1:1) и ацетатный буферный раствор (рН 5,6). Экстракционное (хлороформное) разделение компонентов препарата позволяет извлечь из модельного раствора до 97 % кофеина (pH 11,0 – 12,0) и 98 % фенобарбитала (pH 4,0 – 5,0). Найденные содержания АФС препарата входят в интервал, рекомендованный ОФС.1.4.2.0009.15, что свидетельствует о соответствии качества препарата стандартам GMP.
Синтез, антиаритмическая, гемостатическая, антигельминтная и ларвицидная активность гидрохлоридов (3,3-диалкил-6,7-диэтокси-3,4-дигидроизохинолин-1(2H)-илиден)ацетамидов
Authors: Михайловский Александр Георгиевич , Лихтенштейн Евгения Сергеевна , Рудакова Ирина Павловна , Старкова Алла Валентиновна , Першина Наталья Николаевна
Published: August 2021

Реакцией циклоконденсации Риттера 1,1-(R1)2-2-(3,4-диэтоксифенил)-этанолов с N-R2-N-R3-цианоацетамидами синтезированы гидрохлориды (3,3-диалкил-6,7-диэтокси-3,4-дигидроизохинолин-1(2H)-илиден)ацетамидов (R1 = Me, Et, NR2R3 = NH2, NHMe, пирролидин, пиперидин, гексаметиленимин, морфолин). Гидрохлориды полученных соединений испытаны на антиаритмическую активность (хлоридкальциевая модель), 5 соединений из 11 показали антиаритмическую активность, наиболее активное соединение имело антиаритмический индекс (АИ) 13,9. По влиянию на свертываемость крови 10 из 11 соединений оказались гемостатиками, наиболее активное соединение повышает свертываемость крови на 32,2 %. Шесть веществ по антигельминтной активности превышают пирантел. Ларвицидное (инсектицидное) действие обнаружено для 4 соединений, которые уменьшали продолжительность жизни личинок на 16,8 – 25,0 мин, что превышает эффект имидоклоприда.
Implikasi Tata Kelola Produksi terhadap Kualitas pada Gerabah Desa Pagelaran Kabupaten Malang Jawa Timur
Authors: Hasyimy Muhammad afaf , Hidajat Robby
Published: August 2021

Artikel ini bertujuan mengkaji implikasi tata kelola produksi gerabah di Desa Pagelaran di Malang Jawa Timur. Tata kelola yang dimaksud adalah konsep, sistem, dan hasil produksi gerabah yang dilakukan oleh perajin di Desa Pagelaran. Mengkaji tata kelola tersebut, sebab adanya kecenderungan produksi gerabah semakin terdesak oleh benda-benda buatan pabrik. Hal ini secara perlahan dirasakan oleh para perajin sebagai ancaman. Pada tahun 2020, perajin gerabah di Desa Pagelaran mulai mengawali meningkatkan kualitas produk, yaitu dengan adanya paguyuban yang dipimpin oleh Yatmono (57 th). Upaya paguyuban masih mengalami hambatan, karena kebiasaan konvensional perajin, yaitu menggantungkan pada tengkulak. Sehingga upaya inovasi seringkali mengalami hambatan. Metode penelitian menggunakan deskriptif kualitatif yang difokuskan pada tata kelola produksi gerabah. Data menggunakan metode wawancara, observasi dan kajian dokumen. Teknik keabsahan data menggunakan triangulasi data (sumber) melalui wawancara narasumber kunci, dan analisis data menggunakan teori fungsi dan tata kelola produksi. Hasil kajian menunjukan ada kecenderungan yang dapat diperhatikan dari aspek, (1) tata kelola konvensional dan progresif, (2) perlakukan kualitas untuk produksi bersifat kualitas dan kuantitas, dan (3) tata kelola gerabah yang berdampak ekonomi. Upaya menciptakan produk yang mempunyai dampak perluasan bisnis, sehingga penghargaan terhadap produk gerabah tidak lagi dihitung sebagai kuantitas, tapi barang selalu diposisikan dalam ukuran kualitas.
Catur Guru Dalam Seni Pertunjukan Wayang Wong Millenial
Authors: Ni Made Ruastiti
Published: August 2021

Karya ilmiah ini bertujuan membahas konsep dan implementasi Catur Guru dalam Seni Pertunjukan Wayang Wong Millenial (sebuah model seni pertunjukan baru yang dirancang khusus bagi generasi millenial). Sebagai hasil penelitian kualitatif, pengumpulan data dilakukan melalui studi dokumen, observasi dan wawancara mendalam dengan beberapa informan, yakni pendidik, wakil seniman dan pengamat sosial budaya Bali. Semua data yang terkumpul dianalisis secara kualitatif deskriptif dengan mengunakan teori pedagogik dan teori tindakan sosial Bourdeau. Hasil penelitian menunjukkan bahwa : Pertama, Catur Guru merupakan konsep pendidikan yang meliputi guru swadyaya, yakni Tuhan Yang Maha Esa, guru wisesa (pemerintah), guru pengajian (guru di sekolah), dan  guru rupaka (orang tua di rumah). Kedua, Seni Pertunjukan  Wayang Wong Millenial yang benampilkan lakon Cupu Manik Astagina mengimplementasi ajaran Catur Guru, yakni (1) menggugah kesadaran untuk senantiasa berbakti kepada Tuhan (guru swadyaya), (2) adanya peran dan dukungan pihak pemerintah untuk merawat dan mengembangkan Seni Pertunjukan Wayang Wong (guru wisesa), (3) adanya peran pendidik di sekolah yang membimbing para siswanya agar mencintai seni-budaya bangsanya; dan (4) adanya peran orang tua dalam mendidik putra-putrinya (guru rupaka). Seni Pertunjukan Wayang Wong Millenial juga mengajarkan agar generasi muda Bali “melek teknologi”. Anak-anak yang terlibat sebagai pemain Wayang Wong Millenial diharapkan mampu berpikir kreatif, terampil, komunikatif, kolaboratif, kritis serta siap bersaing dalam arus kompetisi global. Guru dan orang tua siswa perlu mendampingi anaknya dalam mengakses internet untuk mendukung pertumbuhan fisik, perkembangan sosial, intelektual dan kecerdasan spiritual mereka.
The Hero’s Journey: 12 Stages in The Narrative of Animation Boboiboy Movie 2
Authors: Wong Oscar Gordon , Achin Imelda Ann
Published: August 2021

2019 is a phenomenal year for the development of the Malaysian animated film industry as it has successfully produced two superheroes animated films in total. However, the animated film industry in Malaysia is still not competitive at the international level. This can be seen from the 17 animated films that have been produced from 1998 to 2019, only two superheroes animated films managed to get the attention of the audience. This is due to the lack of knowledge of the concept and function of the hero character in animated films. Therefore, the main objective of this paper aims to demonstrate how the Hero’s Journey narrative structure can be applied in BoBoiBoy Movie 2 (2019). This research method involves the use of video analysis tools namely Kinovea and Motion Picture Analysis Worksheet to explain on how the Hero’s Journey of this film conveys the storytelling. The results of this study found that each semicircle Hero’s narrative structure has an important meaning across from one half-circle to the other half-circle. As a result, it explains the concept of peace and chaos as well as stasis and changes in the narrative structure of superhero animated films. This paper will provide information to researchers on the importance and use of the Hero’s Journey approach to analyze superhero animated films.
Ngẫm về hai tấn bi kịch lớn
Authors: Ho Tung Manh , Long Nguyen Thanh
Published: August 2021

Cuốn “Moral Tribes: Emotion, Reason and the Gap between Us and Them” suy ngẫm về hai tấn bi kịch lớn. Bi kịch vềtài sản công và bi kịch về đạo đức lẽ thường.
Làu-ngoi tăng-kể khíu-chọ
Authors: Vuong Quan-Hoang
Published: August 2021

Nếu làm việc lâu dài, và không có được những kết quả động viên hay môi trường hợp tác giúp giải tỏa và lấy lại sự cân bằng, thì vấn đề sức khỏe tâm lý sẽ trầm trọng hơn theo thời gian. Chưa nói tới dẫn đến trầm cảm, và nhiều hội chứng khác.
Statistical Analysis Plan for the Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING)
Authors: Billot Laurent , Monaghan Helen , Wong Muh Geot , Perkovic Vlado
Published: August 2021

The TESTING (Therapeutic Evaluation of STeroids in IgA Nephropathy Global) study is a multicenter, double-blinded, randomised, placebo-controlled trial designed to evaluate the long-term efficacy and safety of oral methylprednisolone, on a background of routine renin angiotensin system (RAS) inhibitor therapy, in preventing kidney events in patients with IgA nephropathy with features suggestive of a high risk of disease progression. This statistical analysis plan (SAP) provides the details of all pre-specified analyses to be conducted at the end of the trial. The SAP was written by the trial statistician, chief investigator, study director and project manager and approved by the management committee.
Broken Connections: The Evidence for Neuroglial Failure in ME/CFS
Authors: Renz-Polster Herbert
Published: August 2021

In spite of decades of research, the pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is still poorly understood. Several pathomechanisms have been identified, yet, it remains unclear how they are related and which of them may be upstream or downstream.. In this paper, we present a theoretical strategy that may help clarify the causal chain of pathophysiological events in ME/CFS. We propose to focus on the common final histological pathway of ME/CFS and suggest to ask: Which cellular compartment may explain the pathological processes and clinical manifestations observed in ME/CFS? Any functional unit consistently identified through this search may then be a plausible candidate for further exploration.For this "histological" approach we have compiled a list of 22 undisputed clinical and pathophysiological features of ME/CFS that need to be plausibly and most directly explained by the dysfunctional cellular unit in question. For each feature we have searched the literature for pathophysiological explanations and analyzed if they may point to the same functional cellular unit.Through this search we have identified the CNS neuroglia - microglia and astroglia - as the one functional unit in the human body which may best explain all and any of the clinical and pathological features, dysfunctions and observations described for ME/CFS. While this points to neuroinflammation as the central hub in ME/CFS, it also points to a novel understanding of the neuroimmune basis of ME/CFS. After all, the neuroglial cells are now understood as the functional matrix of the human brain connectome which operates beyond and above specific brain centers, receptor units or neurotransmitter systems and integrates innate immune functions with CNS regulatory functions pertaining to autonomous regulation, cellular metabolism and the stress response.
Differential expression of protein tyrosine phosphatase, non-receptor type 6 in human epithelial ovarian cancer.
Authors: Mamoor Shahan
Published: August 2021

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding protein tyrosine phosphatase, non-receptor type 6, PTPN6, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. PTPN6 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. PTPN6 expression correlated with progression-free survival in patients with ovarian cancer. These data indicate that expression of PTPN6 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. PTPN6 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.
Inégalité des revenus et confiance organisationnelle en Europe – Perception et réalité
Authors: Dempsuy Clair
Published: August 2021

Les conséquences indésirables liées à des niveaux élevés d'inégalité des revenus sont nombreuses. La littérature existante soutient que les effets négatifs des inégalités sont canalisés par de faibles niveaux de confiance. Cette étude montre que la confiance dans les organisations gouvernementales diminue dans un environnement de forte inégalité. Avec l'introduction d'une mesure subjective de la façon dont les individus perçoivent l'inégalité des revenus, les limitations passées dans la quantification du mécanisme sous-jacent entre l'inégalité et la confiance sont abordées. Une association négative significative entre l'inégalité perçue et la confiance dans les institutions politiques, comme le gouvernement et l'UE, est trouvée en utilisant un échantillon de 27 pays européens.
Sosiologi pendidikan
Authors: Efryawan
Published: August 2021

mata kuliah sosiologi pendidikan
Calibration, inversion and sensitivity analysis for hydro-morphodynamic models
Authors: Clare Mariana , Kramer Stephan , Cotter Colin , Piggott Matthew
Published: August 2021

The development of reliable, sophisticated hydro-morphodynamic models is essential for protecting the coastal environment against hazards such as flooding and erosion. There exists a high degree of uncertainty associated with the application of these models, in part due to incomplete knowledge of various physical, empirical and numerical closure related parameters in both the hydrodynamic and morphodynamic solvers. This uncertainty can be addressed through the application of adjoint methods. These have the notable advantage that the number and/or dimension of the uncertain parameters has almost no effect on the computational cost associated with calculating the model sensitivities. Here, we develop the first freely available and fully flexible adjoint hydro-morphodynamic model framework. This flexibility is achieved through using the pyadjoint library, which allows us to assess the uncertainty of any parameter with respect to any output functional, without further code implementation. The model is developed within the coastal ocean model Thetis constructed using the finite element code-generation library Firedrake. We present examples of how this framework can perform sensitivity analysis, inversion and calibration for a range of uncertain parameters based on the final bedlevel. These results are verified using so-called dual-twin experiments, where the `correct' parameter value is used in the generation of synthetic model test data, but is unknown to the model in subsequent testing. Moreover, we show that inversion and calibration with experimental data using our framework produces physically sensible optimum parameters and that these parameters always lead to more accurate results. In particular, we demonstrate how our adjoint framework can be applied to a tsunami-like event to invert for the tsunami wave from sediment deposits.
Importance-related fillers improve the classification accuracy of the Response Time Concealed Information Test in a crime scenario
Authors: Wojciechowski Jerzy , Lukács Gáspár
Published: August 2021

Purpose. The Response Time Concealed Information Test (RT-CIT) can reveal when a person recognizes a relevant item among other irrelevant items, based on comparatively slower responding. Therefore, if a person is concealing knowledge about the relevance of this item (e.g., recognizing it as a murder weapon), this deception can be revealed. A recent study introduced additional “familiarity-related fillers”, and these items substantially enhanced diagnostic efficiency in detecting autobiographical data. However, the generalizability of the efficiency of fillers to other scenarios remains an open question. We empirically investigated whether new importance-related fillers enhanced diagnostic efficiency in an imaginary crime scenario. Methods. Two hundred and thirty-nine volunteers participated in an independent samples experiment. Participants were asked to imagine either committing a crime (“guilty” group) or to imagine visiting a museum (“innocent” group). Then, all participants underwent RT-CIT testing using either a standard single probe or an enhanced single probe (with importance-related fillers) protocol.Results. The enhanced RT-CIT (with importance-related fillers) showed high diagnostic efficiency (AUC = .810), and significantly outperformed the standard version (AUC = .562). Neither dropout rates nor exclusion criteria influenced this enhancement.Conclusions. Importance-related fillers improve diagnostic efficiency when detecting episodic information using the RT-CIT, and seem to be useful in detecting knowledge in a wide range of scenarios.
Rating Norms Should be Calculated from Cumulative Link Mixed Effects Models
Authors: Taylor Jack Edward , Rousselet Guillaume A , Scheepers Christoph , Sereno Sara C
Published: August 2021

Studies which provide norms of Likert ratings typically report per-item summary statistics. Traditionally, these summary statistics comprise the mean and the standard deviation (SD) of the ratings, and the number of observations. Such summary statistics can preserve the rank order of items, but provide distorted estimates of the relative distances between items because of the ordinal nature of Likert ratings. Inter-item relations in such ordinal scales can be more appropriately modelled by cumulative link mixed effects models (CLMMs). In a series of simulations, and with a reanalysis of an existing rating norms dataset, we show that CLMMs can be used to more accurately norm items, and can provide summary statistics analogous to the traditionally reported means and SDs, but which are disentangled from participants’ response biases. CLMMs can be applied to solve important statistical issues that exist for more traditional analyses of rating norms.
Toddlers search longer when there is more information to be gained
Authors: Ruggeri Azzurra , Pelz Madeline , gopnik alison , Schulz Eric
Published: August 2021

One of the greatest challenges for artificial intelligence is how to behave adaptively in scenarios with uncertain or no rewards. One---and perhaps the only---way to approach such complex learning problems is to build simple algorithms that grow into sophisticated adaptive agents, just like children do. But what drives children to explore and learn when external rewards are absent? Across three studies, we tested whether information gain itself acts as an internal reward and motivates children's actions. We measured 24- to 56-month-olds’ persistence in a game where they had to search for an object (animal or toy), which they never find, hidden behind a series of doors, manipulating the degree of uncertainty about \emph{which specific object} was hidden. We found that children were more persistent in their search when there was higher uncertainty, and therefore more information to be gained with each action, highlighting the importance of research on artificial intelligence to invest in curiosity-driven algorithms.
Gender Inequality In Relational Position-Taking: An Analysis Of Intra-Organizational Job Mobility Networks
Authors: Wilcox Annika , McDonald Steve , Benton Richard A. , Devey Donald Tomaskovic
Published: August 2021

We conceptualize within-organization job mobility as a position-taking process, arguing that the structure and outcome of claims over positions are characteristics of organizational inequality regimes. Drawing on data from 10 distribution centers from a large U.S. firm, we examine gendered job mobility as the observed network of workers moving among jobs. Results from network analysis and meta-regression reveal that in the firm examined, workers tend to move between jobs with similar gender compositions, that mobility lattices tend to be more ladder-like for male-concentrated jobs but more circuitous for female-concentrated jobs, and that there is less upward mobility overall in organizations with higher levels of wage inequality. Both organization level inequalities and the relationship between positions within organizations condition mobility. While we do not observe discursive claims on positions, we argue that these are the underlying mechanisms driving gendered job mobility.
Consumers' Attitude towards Online Shopping in Janakpurdham
Authors: Shah Binod , Tiwari Uday Kishor
Published: August 2021

The paper aims to explore about the use of Internet that changes the way consumers purchase goods and services. The growing number of internet users in Nepal provides a bright prospect for online shopping. Recent research has shown an interest in investigating the factors that affect the attitude of consumers towards online shopping. The study is being carried out to identify and analyze the factors that affect consumers' attitude towards online shopping in Janakpurdham and to examine the factors that motivate consumers to shop online. In this study, quantitative research method has been used. Questionnaire method is used to collect the data. The study has been done by convenient sampling method. The main finding of this study is that among the four factors (convenience, website design/features, time saving and security) selected for this research, the most attractive and influencing factor for online shopping is convenience, followed by time saving the second and thirdly security. Results have also showed that the website design/features are also important for online shopping. The findings also indicate that time saving is the most important factor that motivate consumers to shop online, followed by easy to purchase second and thirdly variety at one shop. This study is useful to understand the online shopping behavior of consumers.
BBS Second Year English Course in TU for the Development of Business Communication Skills
Authors: Timalsina Ramji
Published: August 2021

Skill for effective communication is an essential quality of a business professional. A course on business communication needs to help them develop such a capacity. The course of English entitled ‘business communication’ prescribed in BBS second year in Tribhuvan University has intended to achieve this goal. On this background, this article analyses how the combination of the contents, language skills and recommended pedagogical approach of tis course is useful to achieve the intended goal of the curriculum. The study is based on Content and Language Integrated Learning (CLIL) principles which argue that language learning should be relevant to the future career of the learners. Only such a course can encourage the learners’ involvement and makes a language class lively and goal oriented. Seen from this perspective, the course under analysis connects the value of English with professional competence with its focus on communication, collaboration, critical thinking, and creativity of its learners. The task based learning pedagogical approach makes both the students and teachers active in the classroom and students continue learning language even beyond the classroom set up. Such a course is useful for career based studies.
Skuteczność Narodowego Programu Mieszkaniowego w zakresie społecznej polityki mieszkaniowej
Authors: Sobczak Michał
Published: August 2021

In the first 20 years of the 21st century, the social housing policy in Poland underwent many changes. They resulted from the lack of consistency in this respect and low patience of the ruling parties, which led to profound modifications in the approach to the housing policy practically with every new government. Until the implementation of the National Housing Programme (NHP), the housing policy in Poland was characterised by fragmented solutions, without any comprehensive approach to the issue in question. The aim of the article is to verify the effectiveness of the NHP, especially in terms of its social part, i.e., Mieszkanie Plus [Apartment Plus] package. The programme was described using the framework of theoretical assumptions of the social housing policy and the implementation of this policy in Poland after the year 2000. The author claims that the NHP is the first housing policy in Poland which applies a holistic approach and moves away from the practice of short-term, fragmented solutions. He recommends that those who are in power should exercise patience and refrain from introducing alterations after a very short period from the point of view of investment processes, as the implementation of such a complex housing policy as the NHP is planned for many years.
Isu Lesbian Gay Biseksual Transgender (LGBT) Pada Media Online
Authors: Jaya Sakti Dwi , Afifi Subhan , Triwardani Reny
Published: August 2021

This study discusses the framing analysis of news about the issue of lesbian, gay, bisexual, and transgender (LGBT) on Online Media Jogja (January-March 2016).
Pengaruh Struktur Modal Terhadap Profitabilitas Serta Dampaknya Pada Nilai Perusahaan
Authors: Victoria Laura , Mulyanto Indro Herry , Utomo Hastho Joko Nur
Published: August 2021

This research is to know the influence of the capital structure
PENENTUAN PRIORITAS PENINGKATAN KUALITAS JASA DENGAN MENGGUNAKAN METODE IMPORTANCE-PERFORMANCE ANALYSIS (IPA) DAN INDEKS POTENTIAL GAIN CUSTOMER VALUE (PGCV)
Authors: Arifianto Nur Hakim , Kancana Sauptika , Soeprapto Adi
Published: August 2021

The purpose of the research is (1) analyzing the level of conformity betweenexpectations (importance) customer and performance (performance) of the company against the quality of services provided by Yamaha Motorcycle repair shop (2) Determine the priority Quality improvement based on the level of conformity and index of Potential Gain Customer Value (PGCV) to improve the quality of services provided by Yamaha Motorcycle repair shop. The population in this research is a customer Yamaha Motorcycle repair shop Demangan Yogyakarta for approximately arround 2 months April 2019 till June 2019.Determination of the number of samples will be determined by the level of Confidance 95% and margin of error is 10% then obtained the number of samples as many as 98 people. The sampling techniques used in this study were based on Non Probabiliy Sampling methods using the Accidental Sampling approach.The results showed that (1) the level of conformity between expectations (importance) of the customer and performance (performance) of the company against the quality of services provided by the Yamaha Motorcycle repair shop Demangan Yogyakarta has an average level of conformity Below 100% of which is 88.30%. 88.30% means the company lacks or does not fulfill what is considered important by the customer and the service has not beensatisfactory; (2) Priority of improvement of service quality (top priority in the Quadrant A IPA diagram with index PGCV) namely: 1) Workshop Yamaha new source Motor Demangan has a complete spare parts, 2) equipment used Yamaha Workshop new source Demangan complete, 3) Employees Yamaha Motorcycle repairshop Demangan tell the customers when the service is certainly motorbike will be delivered, 4) Employees Yamaha Motorcycle repair shop Demangan always ready in responding to customer demand, 5) Mechanics workshop Yamaha Motorcycle repair shop Demangan fast In servicing motorcycles, 6) Employees Yamaha Motorcycle repair shop Demangan always able to answer questions related to Yamaha motorcycles, 7) Employees Yamaha Motorcycle repair shop Demangan always prioritize the expectations of customers.
POTENSI, EFEKTIVITAS DAN KONTRIBUSI PAJAK HOTEL TERHADAP PENDAPATAN ASLI DAERAH KOTA YOGYAKARTA
Authors: Darmanto Dita Dwi Agustina , Mulyanto Indro Herry , Suratna Suratna
Published: August 2021

This study aims to determine the potential hotel tax that actually has inYogyakarta City, how far the level of hotel tax effectiveness and how much the hotel tax contribution in the City of Yogyakarta. This research is included in the type of quantitative descriptive research. The population in this study are all hotels in the city of Yogyakarta. The data used in this study are secondary data obtained from the Regional Finance and Assets Agency, Yogyakarta Central Statistics Agency. The sampling technique used is non probability sampling by means of purposive sampling based on selected criteria. The analysis technique uses the analysis of hotel tax potential calculations, analysis of hotel tax effectiveness calculations and analysis of hotel tax contribution calculations.The results of this study point out that the comparison between hotel tax  potential with the realization of hotel tax revenue within five years is from years 2011-2015 there is a big difference, with a potential hotel tax of Rp. 425,219,891,636 and realized hotel tax revenue of Rp. 335,529,045,226, then the local government lost the potential of Rp. 89,690,846,410, from the two hotel classifications in the city of Yogyakarta star hotels that have a greater proportion of potential than non-star hotels. The level of effectiveness shows that hotel tax revenue shows the average percentage is still below 100% with the criteria "Not Effective" so that it can be concluded that the realization ofhotel tax revenue in the city of Yogyakarta has not yet reached the maximum potential, while the level of hotel tax contribution to local revenue in The city of Yogyakarta in accordance with the targets set by the local government shows a percentage above 4% with the criterion "Very Contribute", so it can be concluded that the hotel tax contribution also contributes greatly to local original income in the city of Yogyakarta
AUSTRALIAN HUMAN RIGHTS COMMISSION (AHRC) DALAM MENGURANGI KASUS DISKRIMINASI RAS DI AUSTRALIA TAHUN 2015-2018
Authors: Dani Micaella , Muharjono Muharjono
Published: August 2021

This journal discussing about the efforts of the Australian Human RightsCommission (AHRC) to reduce racial discrimination cases in Australia 2015-2018. The AHRC efforts was defined into five rules and procedures for resolving racial discrimination complaints. They are socialization or early warning, collecting complaints and investigation, fulfillment, continuation of legal actions, and public hearings. The Australia’s moment ratified the rules of the United Nations of Human Rights Commissioner (UNHRC), namely the CERD rules concerning the International Convention on the Elimination of All Forms of Racial Discrimination which sparked the 1975 Racial Discrimination Act could construct the formation of the AHRC in 1986. The principle of UNHRC is an organization known as regime which adopted in Australia in the form of AHRC. This journal aims to discuss, describe and find out the efforts of the Australian Human Rights Commission in reducing cases of racial discrimination in Australia 2015-2018. Explain the rules and procedures for resolving racial discrimination complaints received by the AHRC through five stages of resolution. Afterwards analyze whether the five rules and procedures implemented by the AHRC implemented optimally to reduce racial discrimination cases which happened in Australia in 2015-2018.
Lithostratigraphic definition of the Anisian carbonate-ramp deposit of the Annaberg Formation (Middle Triassic, Northern Calcareous Alps, Austria)
Authors: Moser Michael , Piros Olga
Published: August 2021

Concerning the Middle Triassic stratigraphic succession of the Northern Calcareous Alps (NCA), a modern, litho- and biostratigraphic oriented evaluation of the early- and middle Anisian Annaberg Formation is presented. Due to the fact, that Middle Triassic formations are characterized by a wide distribution within the NCA, any lithostratigraphic definitions of these formations would be of great benefit for mapping geologists, engineers and hydrogeologists. The lithostratigraphic term Annaberg Formation may substitute former designations like “Alpiner Muschelkalk”, “Anisian Limestone and Dolomite” or, partly, “Gutenstein Limestone”. It is exclusively of Anisian age and earlier then the Steinalm and Reifling Formation. Mainly based on microfacies data and lithological data, we define the Annaberg Formation (former: Annaberg Limestone) as one of the most significant Middle Triassic lithostratigraphic units within the NCA. After a detailed description of the type area, findings gained in other areas of the NCA are incorporated to obtain the largest possible overview about the lithological variability and constituents of the Annaberg Formation. As a result, we can describe the Annaberg Formation as mainly organic-rich, medium bedded wackestone, containing remnants of crinoids, little bivalves and gastropods. Typically, fossil-rich layers with accumulations of bivalves and crinoids can often be observed within the Annaberg Formation. In contrast to the Gutenstein Formation no siliceous concretions or fossils (like radiolarians) appear and the fauna is in the main shallow marine. The rock-colour varies from dark- to medium-grey and the bench thicknesses are greater than within the Gutenstein Formation sensu stricto. The fossil content is also larger than in the essentially anaerobe Gutenstein Formation. With respect to the Virgloria Formation the Annaberg Formation is rather planar bedded, not so rich in bioturbation-structures and poor in silica and clay. Hence, the depositional environment of the Annaberg Formation can be described as a restricted carbonate ramp succession, with only minor water movement and separated from the open sea by a shoal with crinoid and brachiopod meadows. Breccias may be an indication for collapse-structures and slumping. In addition, knife-cavity structures (“Messerstichkalke”) indicate an occasional hypersaline environment with precipitation of evaporite-minerals like gypsum. Fossil-rich layers with accumulations of molluscs and crinoids may indicate short-term storm affected sedimentation.
U-Pb dating and composition of columbite from Vishteritsa: Implication for timing of granite magmatism and rare-element granitic pegmatites in the Western Rhodopes, Bulgaria
Authors: Peytcheva Irena , Von Quadt Albrecht , Kostov-Kytin Vladislav , Kadiyski Milen , Stavrev Milen
Published: August 2021

The economic significance of pegmatites as a source of strategic rare metals for high-tech products and green energy motivated the present study on Ta–Nb oxides from Vishteritsa rare-element beryl–columbite LCT pegmatites of the Rila–West Rhodopes Batholith in the Western Rhodopes, Bulgaria. Here, we present the first U/Pb age data from columbite with application of the LA–ICP–MS U–Pb technique and a new X36 columbite standard reference material. The obtained Concordia age of 47.57 ± 0.32 Ma with a small spread of the individual 206Pb/238U ages between 45 and 51.3 Ma argues for Early Eocene magmatism and pegmatite formation. The host granite of the rare-element pegmatites is dated 51.94 ± 0.61 Ma with LA–ICP–MS U–Pb technique on zircon and suggests a fertile Early Eocene magmatic period in the Western Rhodopes. EPMA data for the composition of the columbite is used to refine the formula of the mineral (Mn0.554Fe0.427U0.006)0.987(Nb1.826Ta0.085Ti0.116)2.03O6 and define it as columbite-(Mn). Application of the in-situ LA–ICP–MS data technique establishes a series of typical trace elements (Ti, U, Zr, Hf, Y, W, and Zn) that are usually found in content above 500 ppm. The studied columbite is enriched in heavy rare earth elements (HREE sum: 306–697 ppm) and depleted in light REE and Eu. These geochemical characteristics are collectively interpreted as evidence for crystallization from highly fractionated fluid-rich magma. High UO2 content reaching 0.89 wt. % is characteristic for the Vishteritsa columbite. The decrease of U proximal to cracks and in outer crystal zones documents U-mobility during overprinting hydrothermal processes.