bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGELOMPOKAN SAHAM MENGGUNAKAN K-MEANS DALAM PEMBENTUKAN PORTOFOLIO OPTIMAL
Authors: DEVI ADE AYU NITA , DHARMAWAN KOMANG , TASTRAWATI NI KETUT TARI
Published: January 2024

K-Means clustering analysis is a technique used in grouping objects that have similar characteristics. In forming a portfolio, investors need a group of stocks from different sectors that aim to build a well-diversified portfolio. Portfolio diversification is the placement of assets from various stocks in such a way that risks can be minimized. This study aims to obtain the results of grouping stocks with K-Means at IDX80 and then determine the optimal portfolio of each cluster formed using the Mean Variance method in the period January, 1st 2020 to November, 10th 2022. As a result, obtained in this study that grouping with K -Means produces four groups and  is the best portfolio consisting of 10 stocks with a Sharp ratio performance value of 0.0062 with a risk portfolio of 1.59% and an expected return portfolio of 0.17%.
Occult hepatitis B infection and clinical implications; a systematic review
Authors: Jafari Amirah , Hamzi ‏Shaima , Rdaei ‏Alaa , Khowaji Atyaf , Abdulfattah Ebtehal , Musawi ‏Raghad , Abdali Abdulaziz , Bakri Hanan
Published: January 2024

Occult hepatitis B infection (OBI) is the presence of replication-competent DNA of the hepatitis B virus in the blood or liver of individuals who display a negative test for hepatitis B surface antigen. There are many clinical implications of OBI, including blood product transfusion, the occurrence of cirrhosis, hepatocellular carcinoma (HCC), and liver transplantation. OBI is associated with the development of hepatocellular carcinoma and might influence the progression of the disease, and the response of chronic hepatitis C to the treatment. Thus, this review was conducted to assess the clinical implications of OBI by reviewing the previous studies conducted on this subject. Electronic databases, including PubMed, BioMed Central, Scopus, Elsevier, Springer, Cochrane Library, Web of Science, and Science Direct, were revised for articles published between 2013 and 2023. A total of 2,880 articles were obtained, and only ten articles were found eligible and were included in the final analysis. There was heterogeneity in findings between the included studies; however, it was concluded that OBI could cause the progression to HCC and cause deterioration in HCV patients based on the presence of additive risk factors.
The Role of Pharmacists in Fighting Substance Abuse: A Systematic Review
Authors: Jaafari Malak , Hindi Mohammed , Hadadi Amal , Khobrani Rawan , Hakami Elaf , Humedi Rayyanah , Hadadi Zainab , Shutayfa Asma , Haidar Latifah
Published: January 2024

Pharmacists are crucial to caring for patients who use and abuse psychoactive substances, especially those with substance use disorders, in all care settings. The Association for Multidisciplinary Education and Research in Substance Use and Addiction (AMERSA) has created key skills for pharmacists to address substance use in the 21st century to maximize, maintain, and increase these independent and collaborative responsibilities. Thus, this study aims to explore the role of pharmacists in fighting substance abuse. This is an updated systematic review of studies on the role of pharmacists in fighting substance abuse between 2019 and 2022. The PubMed and Google scholar databases were used to explore studies regarding our subject. The keywords included "Role, Pharmacists, Fighting, Substance, and Abuse" and were used in various combinations. Original research reporting medical therapies used in the role of pharmacists in fighting substance abuse and full-text publications served as the inclusion criterion.Though 150 articles were obtained, only eight met the inclusion criteria. The review involved community pharmacists; all the studies were cross-sectional. The most abused prescription and non-prescription drugs were anti-malarials and simple analgesics, over-the-counter (OTC), opioids, prescription medicines, and Pregabalin. Nearly half of the studied pharmacists received substance use disorder (SUD) education concerning pharmacists\' knowledge and perceptions in pharmacy school. The number of years worked significantly predicted knowledge and screening. Relationships between knowledge, attitudes, and practices indicate a need for experiential education that includes psychosocial aspects of care. This clarifies that the pharmacists\' role in preventing drug abuse is significant. Training programs influenced pharmacists\' attitudes and perceptions about targeted behaviors and associated them with the value of screening for opioid misuse or overdose risk and counseling patients about the benefits and risks of opioids.
Japan's Manchurian Policing and Arms Enhancement to Prepare for the Sino-Japanese War
Authors:   The Korean Association For Japanese History, YOO JIA
Published: January 2024

The 1933 Tanggu Armistice Agreement reduced military conflict between China and Japan. However, Japan resumed its invasion of China in 1935 with the separation of Hebei. As a result, tension between China and Japan reached its peak again. Accordingly, Japan tried to prepare for a war with China by strengthening security and arms against Manchuria. In particular, China-China relations deteriorated rapidly toward the end of 1936. And in June 1937, just before the outbreak of the Sino-Japanese War, Japanese Kwandong Army and Soviet Army clashed in northeastern China. Since then, Japan has carried out a military reorganization in northeastern China and also carried out reforms to the Manchurian Army. The reform was mainly centered on the integration of the military and police central organization. In addition, in the late 1936, Japan spent a lot of money to reorganize the armaments of Manchuria, and the weapons possession situation of Manchurian troops more than doubled compared to before.
In addition, since 1936, Japan has conducted a security settlement in Manchuria to respond to the all-out war. The main contents are based on the security plan of the Manchurian army and the Foreign Ministry police. In particular, this security policy includes ideological work, which promoted a basic ideological exhibition that recognizes the excellence of nationalism in life while promoting the principles of people's lives. At the same time, an exhibition of wartime thought was held to strengthen the ideological general mobilization system in the urgent environment before the war. As such, Japan has already been strengthening security and arms against Manchuria as a preparatory step for invading China since the middle of 1936. Because of this preparation, it was possible to start a war without a declaration of war when the Lugouqiao incident occurred.
Deregulation of Lipid Homeostasis in Metabolic dysfunction–Associated Fatty Liver Disease (MAFLD)
Authors:   Janssen Pharmaceutical Companies Of Johnson And Johnson, Bhat Neha
Published: January 2024

one of the rate-limiting enzymes of gluconeogenesis pathway [12,14,15]. Overall, the functions of liver, skeletal muscles, adipose tissue, and pancreas, get adversely affected and precipitates into MAFLD.
Interventions for Mental Health Care in Gestation and Puerperium Review
Authors:   Barrio Del Pilar Health Centre, Fernández Y Fernández-Arroyo Matilde
Published: January 2024

Introduction: The foundations of a person's health are intimately related to physical and psychological maternal health. Physical care is protocolised and rapidly disseminated throughout the health care However, psycho-emotional care of pregnant and postpartum women receives less attention.
Habitual Abortion in Hansen’s Morbus
Authors: Atfi Ismi Mulya
Published: January 2024

Based on WHO data, Indonesia is one of the countries contributing around 10,000 cases of Hansen’s morbus  2019. Hansen's morbus, or leprosy, is a chronic bacterial infection (Mycobacterium leprae) that attacks skin tissue, peripheral nerves, and the respiratory tract. Hansen's disease can occur during pregnancy and worsen during pregnancy. Pregnancy causes a relative decrease in cellular immunity. This can be explained because immunosuppression occurs during pregnancy. Pregnancy is dangerous for women with Hansen’s morbus . This case study describes a case of habitual abortion with Hansen’s morbus . The patient had a history of Hansen's morbus and had discontinued the medication. During pregnancy, the patient never underwent examination and treatment for Hansen's morbus. So, the patient experiences the habit of abortion. For this reason, it is necessary to carry out good treatment for pregnant women with Hansen's disease so that the mother and fetus receive appropriate treatment.
E-Booklet media can increase teenagers' knowledge about breast self-examination
Authors: Dahliana Maya Dika , Agustina Indah Fitri
Published: January 2024

Breast cancer in women is the highest number of cancer cases in the world. Adolescents aged 10-21 years with breast cancer are often found at an advanced stage. This incident was caused by the low knowledge of teenagers about early detection of breast cancer with BSE. This research aims to determine the effectiveness of e-booklet media in increasing young women's knowledge regarding breast self-examination (BSE). This research is quantitative with a pre-experiment research design with a pre-test and post-test design without a control group design. The sampling technique in this research uses a probability sampling technique with a Simple Random Sampling approach. The sample consisted of 81 respondents who were high school students in DKI Jakarta. The research results showed an increase in the average knowledge score of young women after being given the E-Booklet media about BSE with a p-value < 0.001. Health service institutions and schools can utilize E-Booklet media during health education, especially for young women regarding BSE.
Mastitis in lactating women: A case report
Authors: Yulizawati Yulizawati , Silmi Harridhil , Intasir M. Pemberdi
Published: January 2024

Mastitis, or breast inflammation, is classified as either non-lactational or lactational. Mastitis that occurs during lactation is the most prevalent type. Worldwide, only 50% of women are able to breastfeed for six months. It could be the result of an inflammatory breast condition, such as puerperal mastitis or milk stasis, which in certain cases requires supplementation or stopping breastfeeding entirely. We describe a complicated case of a primipara patient who appeared three months after giving birth with lactational mastitis. In this review, we emphasize how crucial multidisciplinary teamwork using Midwifery care is to accurate diagnosis and successful treatment. We go over the usage of oral antibiotics and provide examples of the kind of client support needed to help patients heal and successfully breastfeed during the postpartum phase. Giving the mother the right care and guidance is therefore crucial since poorly managed mastitis can result in an early end to breastfeeding and cause suffering for both the mother and the child.
THE COMMODIFICATION OF POPULAR MUSIC IN DIGITAL ERA (Case Study of Music Label’s Sun Eater)
Authors: Putra Noverdy , Chatra Emeraldy , Roem Elva Ronaning , Putera AB Sarca
Published: January 2024

The development of digital technology has changed the business structure of the music industry. The presence of social media and music streaming services adds to the size of the music industry itself, starting from the intersection of various actors (music labels, artists/musicians, music streaming service applications, music consumers), interests (business and state regulations), to power (distribution networks), especially in the perspective of the political economy of communication. In the context of this research, the object of research is the independent music label Sun Eater. This study uses a qualitative research method with an intrinsic case study approach. In line with that the data collection used is observation, in-depth interviews and documentation studies. The results of this study indicate that the content commodification carried out by Sun Eater as a music label is not focused on the music itself. But it wraps up the issues of today's youth and makes them like lyrics, pictures and videos. In audience commodification, Sun Eater does not put the audience as mere music fans. However, with a consumer-centric and data driven approach, Sun Eater treats their audience (music fans) like mass media, by “selling” back on advertisers on various digital platforms. Finally, the Commodification of Workers, that musicians are not just music workers. Moreover, Sun Eater places musicians as workers who have other responsibilities, ranging from filming digital content, interacting with fans on social media, to photo shoots with advertisers.
Pengenalan Konsep Dasar Animasi 2D dan 3D kepada Anak SMA/SMK di Wilayah Provinsi Banten
Authors: Suni Eugenius Kau , Sutresno Stephen Aprius , Sihombing Denny Jean Cross , Christanto Henoch Juli , Bata Julius Victor Manuel , Airlangga Gregorius , Setiawan Yohanes Evan
Published: January 2024

Given the rapid development of technology, education in the field of technology becomes crucial for everyone. One of the roles of technology education in fostering someone's creativity can be achieved through learning about things that require creativity, such as animation in the digital world. The Information Systems Program at Atma Jaya Catholic University of Indonesia organized a community service activity in the form of a workshop on November 25, 2023, covering the introduction to the basic concepts of 2D and 3D animation. The workshop was facilitated by Edwar Juanda, S.Ds., M.Ikom, as the speaker, and was attended by 90 participants from high schools and vocational schools in various areas around the Banten province. The workshop proceeded smoothly, and the participants appeared very enthusiastic and active throughout the event. Particularly during the workshop session, participants took turns trying out Virtual Reality tools provided by the speaker. It is hoped that this workshop will provide a broader insight into the younger generation regarding the application of technology, especially in the creation of 2D and 3D animations.
Texas’s Water Future: Legal, Business, Environmental, and Regulatory Concerns
Authors: Royce Robert
Published: January 2024

Around the world freshwater is increasingly scarce, and Texas is no different. Texas continuously operates at a shortage, where freshwater supply cannot meet demand. Projections show that this deficit will increase over the next decade, which would cause billions of dollars in losses for the Texas economy. But Texas is in a unique position to correct its water problems and take corrective measures to avoid such losses. Innovations around hydraulic fracturing in the oil and gas industry, namely recyclable “produced water” and the burgeoning “water midstream” sector will play an important role in remediating Texas’ freshwater scarcity concern. Furthermore, the technological advancements in recyclable produced water, combined with an effective business model and operational infrastructure of the water midstream sector, would generate a consistent source of freshwater for industrial, manufacturing, and agricultural uses that will mitigate the strain on natural freshwater sources.

Private actors continue to fund and build facilities to gather, recycle, and distribute produced water; but there are barriers to expansion of these systems. While the private sector has a foundational blueprint to utilize recyclable produced water, there are business, legal, environmental, and regulatory concerns that must be addressed by the Texas government to pioneer a sustainable water future that will greatly benefit Texas’s economy and residents. The Texas government must adopt a proactive approach to thi
Kajian Pengaruh Perbedaan Kerapatan Tanam dan Tahun Tanam terhadap Produktivitas Kelapa Sawit
Authors: Prasetio Ryan , Wirianata Herry , Tarmadja Samsuri
Published: January 2024

The oil palm yield depends on its genetic and the interaction with environmental factors is affected by spatial arrangement of palm trees. The research objectives are to determine the effect of population density and planting year on oil palm productivity and vegetative growth. This research uses a factorial design arranged with a randomized complete design. Secondary data are palm productivity, fresh bunch number and bunch weight that were collected for three years (2019—2022). Primary data are stem height, frond length, and stem gird which were measured on 90 trees for each treatment combination. There are nine combinations with 810 palm trees that were sampled from 27 estate blocks (30 hectares for one block). The results showed that productivity and amount of oil palm FFB at densities ≥ 142, 136-141, and ≤ 135 SPH and planting years 2007, 2009 and 2011 (mature crop 12-15, 10-13, and 8-11 years) did not show significant differences. The heavier bunch weight was produced palm tree planted in 2007 with density ± 135 trees.ha-1.
A rare presentation of kikuchi disease as hemophagocytic lymphohistiocytosis
Authors: Kasarabada Harish , Singhal Megha , Singh Deependra , Iyengar Sreenivasa , Joshi Sudhir
Published: January 2024

This case report deals with a young lady in her late 20’s who presented as a case of pyrexia of unknown origin complicated by the rapid development of encephalitis transaminitis and pancytopenia within a span of 24 h and later succumbed to her illness. Her clinical diagnosis and cause of death were hemophagocytic lymphohistiocytosis (HLH) secondary to neutropenic sepsis; however, an autopsy was recommended to ascertain the exact cause of death. Her autopsy examination revealed numerous necrotic enlarged lymph nodes with elevated lactate dehydrogenase levels in peritoneal fluid. The final diagnosis was multiorgan failure due to HLH in the case of Kikuchi disease. Kikuchi disease is usually a benign self-limiting illness presenting most commonly as cervical or axillary lymphadenopathy. This case report highlights a fatal case of Kikuchi disease due to HLH, which is an extremely rare entity.
The observed correlation between New Zealand gym member’s perceived level of technique and rate of injury – A research survey
Authors: Williams Brogan Samuel
Published: January 2024

Objectives:

Many in the rehabilitation and fitness community agree that technical ability, skill, or technique is of the utmost importance regarding sports performance. However, whether or not it directly impacts one’s rate of injury or ability to prevent or screen injuries is not unanimous. This study sets out to examine any correlation between a New Zealand gym member’s perception of their own lifting quality, skill, and ability and their rate of injury. The research question was, “Is there a correlation between subjective self-reported technique and the prevalence of injury?”

Material and Methods:

The sample size was n = 70. A convenience sampling method was used, and a 5-question survey was posted on social media (Instagram and Facebook) and open to all who met the inclusion criteria.

Results:

Out of 70 participants, 56 self-reported a level of technique between 6 and 10/10. Fourteen participants reported a level of technique between 1 and 5/10. Of the 56 that fell within 6–10/10, 60.8% did not experience any injuries within the gym for the previous 24 months, with an average of 7.73/10 (±4.2%) (confidence interval [CI]: 7.404–8.056). In addition, 62.5% did not experience any injuries outside of the gym for the previous 24 months. Out of the 14 participants who self-reported 5/10 or less, 100% of them reported that they experienced injuries within the previous 24 months, with an average of 4 ± 0.592 (±14.8%) (CI: 3.408–4.592). In addition, 71.4% said yes to injuring themselves outside the gym within the previous 24 months.

Conclusion:

It can be observed from this study that one’s perception of technical ability in the gym may be correlated to how often they are injured. Further research investigating this correlation is required to reach a stronger conclusion.
Assessment of volatile organic compounds in indoor and outdoor environment – A study on air quality impact assessment
Authors: Mythili K. , Gayatri S.
Published: January 2024

Objectives:

Volatile organic compounds (VOCs) are a type of pollutant that causes health risks and can be present in both indoor and outdoor environments. VOCs originate mainly from solvents and chemicals used at home or in offices and also from vehicle emissions. The current research work was aimed at the detection and quantification of VOCs indoor and outdoor at Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, India.

Material and Methods:

Air was drawn through an adsorbent tube with a pump at a steady flow rate (100 mL min-1) for an hour to gather samples using the active sampling approach. Thermal desorption in combination with a gas chromatography (GC) analyzer was used to estimate the levels of hazardous VOCs, namely benzene, toluene, ethylbenzene, m-xylene, p-xylene, and o-xylene (BTEX) compounds.

Results:

VOCs were analyzed using the GC-mass spectroscopy technique. The finding shows the levels of BTEX as benzene (0.05–0.11 μg/m3), toluene (0.44–1.27 μg/m3), ethylbenzene (0.012–0.03 μg/m3), m-xylene (0.009–0.027 μg/m3), p-xylene (0.007–0.025 μg/m3), and o-xylene (0.003–0.019 μg/m3) compounds.

Conclusion:

The BTEX levels were observed to be well below the maximum acceptable limit. VOC emissions can be reduced by making process changes or by installing air pollution control equipment.
In silico assessments of bioactive compounds from Dayak onion (Eleutherine bulbosa) as antibacterial agents targeting UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA)
Authors: Naibaho Frans Grovy , Maulina Anita , Panjaitan Desimaria , Hartanto Adrian
Published: January 2024

Antibiotic resistance is a formidable global health challenge, a concern that also occurs in Indonesia. Dayak onion (Eleutherine bulbosa), a traditional medicinal plant, holds promising potential as a natural remedy. This study focused on in silico assessment on the antibacterial potential of Dayak onion metabolites as future antibiotics. MurA protein (PDB ID: 1UAE) was selected as the target protein. Eleuthoside C displayed the most favorable binding with a remarkably low ΔG value of -10.5 kcal/mol, denoting robust stability, followed by Eleutherinoside A (-10.1 kcal/mol) and 2,5-dimethyl-10-hydroxynaphtopyrone 8-O-β-glucopyranoside (-10.0 kcal/mol). In contrast, the standard drug fosfomycin showed a lower binding affinity (-4.6 kcal/mol). Eleuthoside C demonstrated 100% of binding site similarity (%BSS), closely followed by Eleuthoside B (91.30%), Eleutherinoside A (78.26%) and Eleutherinoside B (78.26%), with the main target to Cys115. The druglikeness criteria was only fulfilled by Eleutherinoside A, yet being proposed as the alternative lead compound for antibiotic treatment of pathogenic bacteria.
Investigation of herbal dyes from Symplocos racemosa (Lodh) leaves and optimization of procedure for dyeing using synthetic mordants
Authors: Singh Shyam Vir
Published: January 2024

The present study deals with the soaked and woven wool fabrics that were dyed with natural dyes extracted from the leaves of Symplocos racemosa (Lodh). The optimization was carried out with different conditions like concentration of dye material, time for extraction of dye, dyeing time and concentration of mordants. Out of the three methods of mordanting, the best shades for lodh leaf dye were obtained using post-mordanting with ferrous sulphate and stannous chloride and simultaneous mordanting with copper sulphate and potassium dichromate. Poor results were observed in the case of pre-mordanting. The colour fastness analysis indicated the light-coloured samples were affected more rapidly as compared to the dark ones. In this study, the lodh leaf dyed samples exhibited fairly good to excellent fastness to light in the case of ferrous sulphate and stannous chloride while good to good in both copper sulphate and potassium dichromate respectively and the results of washing fastness analysis revealed that lodh leaf dyed samples had good to excellent fastness to washing.
Synthesis, Characterisation, in vitro antibacterial and in silico docking studies of Schiff bases of p-nitro benzaldehyde
Authors: Sangeetha T.V. , Bhuvaneshwari N. , Saranya G.
Published: January 2024

Schiff base ligands have more pharamaceutical applications and are widely used in pharmaceutical industries. Herein, two kinds of Schiff base ligands were synthesized using p-nitrobenzaldehyde with (L1) 1H-1,2,4-triazol-3-amine and (L2) 1,4 phenylene diamine backbone. Synthesised ligands were characterized utilizing ultraviolet visible spectroscopy, Fourier Transform Infra-red Spectroscopy, Carbon 13C NMR and Proton 1H. Then in vitro antimicrobial activity, PASS analysis, Drug likeness and in silico docking studies of synthesized ligands (L1 and L2) were carried out. With the help of PASS and bioactive score results, docking studies were done using two different proteins (PDB ID:6D9T and PDB ID:6HZQ) by Auto dock 4.2.6 program. BNBBDA has good affinity with target protein S. aureus (PDB ID:6D9T) and PNBTAA has with protein E.coli (PDB ID:6HZQ). The findings demonstrated that the compounds are the ideal candidates for the subsequent steps of drug discovery.
Amalgamation, characterization and biological assay of benzyltrimethylammonium chloride
Authors: Deepthi B.V. , Isac Sobana Raj C.
Published: January 2024

The year 2020 appeared to be a massive loss of human population due to the COVID-19 virus. During that period of time, different medicines were utilised as disinfectants to minimise the spread of the virus. Among those, quaternary ammonium compounds were the most likely to be utilised as disinfectants. In this study, a quaternary ammonium compound namely benzyl-trimethylammonium chloride was synthesised at 0.1N to 0.8N concentrations and tested to find the activities of bacteria and fungi. Since this compound prosperously acts against bacteria and fungi, it can also truncate the spread of diseases caused by viruses. Research has proved that if an anti-microbial solution has the faculty to kill bacteria, then it also has viral activity. Then this solution is dissolved with protein powder and studied against protein solubility test. Furthermore, in this research, FTIR and UV spectral analyses of benzyl-trimethylammonium chloride were taken and explicated in brief regarding its functional group and absorption wavelength. This quaternary ammonium compound is very useful for mankind.
Structural parameters of amphetamine: A DFT approach
Authors: Arya B. , Sachidanandan P. , AnandaKumar V.M.
Published: January 2024

The structural parameters of Amphetamine, a significant psychoactive drug, are investigated experimentally and computationally using spectroscopic and DFT methods. The molecule is subjected to optimization using the B3LYP functional with both 6-311+G (2d,p) and augmented cc-pVTZ basis sets. Resulting values are then compared against published crystal data for validation. Analysis of the Fourier Transform Infrared and Raman spectra is carried out with PED assignments and after scaling, the calculated spectral frequency values are verified with experimental spectra, revealing a favorable match between them. The NMR spectrum of the molecule is obtained using TD-DFT techniques. The quantum theory of atoms in molecules is employed to analyze the electron density distributions. The reactivity of the molecule is predicted using various tools including analysis of the molecular electrostatic potential surface, electron localized function, molecular graph, non-covalent interaction (NCI), Hirshfeld charge, frontier orbital as well as local and global reactivity descriptors. Natural bonding orbital analysis identifies the hybridization, charge transfer and correlation effects. The results of this study could be utilized for the development of novel chemical sensors for drug detection and to predict the correlation between the structure and pharmacological activity of various amphetamine derivatives.
Ethological and immunological interrelations in experimental desynchronosis under fluorescent lighting conditions
Authors: Осиков М.В. , Бойко М.С. , Огнева О.И. , Федосов А.А.
Published: January 2024

Цель – изучение особенностей иммунного статуса и поведенческой активности при экспериментальном десинхронозе в условиях люминесцентного освещения. Методы. Световой десинхроноз создавали у морских свинок круглосуточным (24 ч) содержанием в условиях люминесцентного освещения. Для анализа этологического статуса использовали: тест открытое поле, водный «лабиринт» Морриса, определяли в крови содержание интерлейкина-4 (IL-4), интерферона-γ (INF-γ), концентрацию мелатонина и кортизола. Результаты. При экспериментальном десинхронозе в условиях круглосуточного люминесцентного освещения зафиксировано снижение концентрации в крови IL-4, INF-γ и мелатонина и увеличение концентрации кортизола на 10-е, 20-е и 30-е сутки. Корреляционный анализ показал, что при экспериментальном десинхронозе в условиях люминесцентного освещения появляется чувство тревоги, нарастает угнетение ориентировочно-исследовательской активности по мере снижения концентрации мелатонина и повышения уровня кортизола в периферической крови. Заключение. Изменения этологического и иммунного статуса при экспериментальном десинхронозе в условиях люминесцентного освещения прогрессируют по мере снижения концентрации мелатонина и повышения уровня кортизола в крови.

Aim. To identify changes in immune status and behavioral activity during experimental desynchronosis under conditions of fluorescent lighting. Methods. Light desynchronosis was created by exposing guinea pigs to 24 hr of fluorescent light. To analyze the ethological status, we used an open field test, a Morris water maze, and the concentrations of IL-4, IFN-γ, melatonin, and cortisol in the blood were measured. Results. During experimental desynchronosis under fluorescent light, blood IL-4, IFN-γ decreased and melatonin increased. There was an increase in the concentration of cortisol on days 10, 20 and 30. Correlation analysis revealed that in experimental desynchronosis, anxiety and depression of research activity increased as the concentration of melatonin decreased and as the concentration of blood cortisol increased. Conclusions. Changes in the ethological and immune status during experimental desynchronosis under fluorescent light progress as the concentration of melatonin decreases and the concentration of cortisol in the blood increases.
Apples to Apples: Shift from Mass Ratio to Additive Molecules per Electrode Area to Optimize Li-Ion Batteries
Authors: Zhang Bojing , Merker Leon , Vogler Monika , Stein Helge Sören
Published: January 2024

Electrolyte additives in liquid electrolyte batteries can trigger the formation of a protective interphase (SEI) atthe electrodes that aims to suppress side reactions at the electrodes. Studies of varying amounts of additives have been done over the last years, providing a comprehensive understanding of the impact of the electrolyte formulation on the lifetime of the cells. However, these studies mostly focus on the variation of the mass fraction of additive in the electrolyte while disregarding the ratio (radd) of the additive's amount of substance (nadd) to the electrode area (Aelectrode). Herein we utilize our extremely accurate automatic battery assembly system (AUTOBASS) to vary electrode area and amount of substance of the additive. The data provides strong evidence that reporting the mass ratios of electrolyte components is insufficient and the mol of additive relative to the electrodes’ area should be reported. Herein, the two most utilized additives, namely fluoroethylene carbonate (FEC) and vinylene carbonate (VC) were studied. Each additive was varied from 0.1 wt.-% - 3.0 wt.-% for VC, and 5 wt.-% - 15 wt.-% for FEC for two mass loadings of 1 mAh/cm2 and 3 mAh/cm2. To engage the community to find better descriptors, such as the proposed radd, we publish the dataset alongside this manuscript.
PFAS destruction and near complete defluorination of undiluted aqueous film-forming foams at ambient conditions by piezoelectric ball milling
Authors: Yang Nanyang , Guan Yunqiao , Yang Shasha , Olive Caitlyn , Fernando Sujan , Holsen Thomas , Yang Yang
Published: January 2024

The non-thermal destruction of aqueous film-forming foam (AFFF) stockpiles, one of the major culprits responsible for water and soil contamination by per- and polyfluoroalkyl substances (PFAS), is extremely challenging because of the coexistence of mixed recalcitrant PFAS and complicated organic matrices at extremely high concentrations. To date, the complete defluorination of undiluted AFFF at ambient conditions has not been demonstrated. This study reports a novel piezoelectric ball milling (BM) approach for treating AFFF with a total organic fluorine concentration of 9,080 mg/L and total organic carbon of 234 g/L. Near-complete defluorination (> 95% conversion of organofluorine to fluoride) of undiluted AFFF was achieved by co-milling with boron nitride (BN). By carefully examining the experimental data, we identified AFFF liquid film thickness (Z) at the collision interface as a descriptor of treatment performance. We further validated that effective defluorination proceeded when Z was less than a criteria value of 2.3 μm. In light of this new understanding, the addition of SiO2 as a dispersant and the pre-evaporation solvents to reduce Z have been validated as effective strategies to promote AFFF treatment capacity.
Performance of density functionals for excited-state properties of isolated chromophores and exciplexes: Emission spectra, solvatochromic shifts, and charge-transfer character
Authors: Patra Abhilash , Pipim George Baffour , Krylov Anna I. , Sharada Shaama Mallikarjun
Published: January 2024

This study assesses the performance of various meta-generalized gradient approximation (meta-GGA), global hybrid, and range-separated hybrid (RSH) density functionals in capturing excited-state properties of organic chromophores and their excited-state complexes (exciplexes). Motivated by their uses in solar energy harvesting and photoredox CO2 reduction, we use oligo-(p-phenylenes) and their excited-state complexes with triethylamine as model systems. We focus on the fluorescence properties of these systems, specifically emission energies, solvatochromic shifts, and wavefunction characteristics. The latter is described using reduced quantities such as natural transition orbitals (NTOs) and exciton descriptors. The functionals are benchmarked against the experimental fluorescence spectra and the equation-of-motion coupled-cluster method with single and double excitations (EOM-CCSD). The results show that, both in isolated chromophores and in exciplexes, meta-GGA functionals drastically underestimate the emission energies, and exhibit significant exciton delocalization and anti-correlation between electron and hole pair. The performance of global hybrid functionals depends strongly on the percentage of exact exchange. RSH GGAs are the best-performing functionals identified in our study, with ωPBE demonstrating the best agreement with experimental results. RSH meta-GGAs often overestimate emission energies in exciplexes and yield larger hole NTOs. Their performance can be improved by optimally tuning the range-separation parameter.
EFFECTS OF HERBAL PLANT EXTRACTS ON INDUCING ROOTING OF STEM CUTTINGS
Authors: Ali Wagan Maqsood , Fatima Miano Tanveer , Ali Wagan Farhan , Chandio Sagar Raza , Shabrani Haseeb Ahmed , Kumar Ajay , Suthar Munesh , jeeamfraz sar , Lal Roshan
Published: January 2024

In the present observe, an experiment was conducted in which the effect of Aloe vera Gel for Inducing Rooting of Stem Cuttings. A pot test was done at the Sindh agriculture university tando jam, sindh, Pakistan, throughout the duration from March 2022 to June 2022 to quantify the have an effect on of Aloe vera gel on, root induction of cuttings of Rose (Rosa indica). completely randomized layout was used to the arrange the experiment with 4 treatments (T1-cutting end dipped in the Aloe Vera gel for 5 mins, T2-reducing cease dipped in Coconut Water for 4 mins, T3- reducing quit dipped in Honey for 5 minutes, T4 (control) without applying Aloe Vera gel or growth regulator to cutting) to determine/ study the effect of the Aloe vera gel on root induction of cuttings of Rose (Rosa indica) to decide/ take a look at the impact of Aloe vera gel on root induction of cuttings of Rose (Rosa indica). in the experiment in which eight-10 inches lengthy cuttings 5 cuttings of the rose for each remedies changed into gathered, and dipped in remedies T1-reducing stop dipped in Aloe Vera gel for 5 minutes, T2-reducing stop dipped in Coconut Water for 4 mins, T3- reducing stop dipped in Honey for 5 minutes, T4 (control) without applying Aloe Vera gel or growth regulator to cutting, were established. General media of canal slit+ FYM+ Clay Soil (1:1:1) became used as a rooting medium. All pots had been stored in a shaded residence to provide a cool and shaded environment. The outcomes indicated high impact of the natural plant extracts for Inducing Rooting of Stem cuttings including rooting percent, overall number of roots per cutting, overall number of bud formation per cutting, and root length. the highest rooting percentage about (96%), greatest number of Roots per cutting (9),total number of buds formation per cutting (five), and the best period of root approximately (6.fifty four cm) found from T1, rather, the bottom rooting percent about (fifty two%) lowest range of roots per reducing (five) the lowest period of root approximately (four.34 cm), end result became determined from the (T4) manipulate, these treatments were observed through rooting percent approximately (ninety%), overall quantity of roots per cutting (8), total number of buds formation per cutting (4) and the length of root approximately (5.52 cm) T3, rooting percentage about (80%), overall number of roots per cutting (6), overall number of buds formation per cuttings (four) length of root about (5.22 cm) T2.
SOIL MANAGEMENT APPROACH FOR AGRICULTURE IN NEPAL: A REVIEW
Authors: Regmi Susma , Neupane Adarsha , Neupane Suprina
Published: January 2024

This paper reviews the various approaches to soil management for agriculture in Nepal based on the already published information. Agricultural soil management must be included in SDG goals, as it needs more management practices and awareness. Though it is not closely related to United Nations Sustainable Development Goals, it is necessary to do soil management to achieve most of the allocated goals. People must implement sustainable soil management approaches, which might increase soil productivity to catch the larger food demand. However, most of Nepal’s farmers are implementing a traditional cropping system along with poor management practices that hamper soil hazardously and decrease soil productivity. In contrast, few people apply sustainable practices like fodder promotion, integrated plant nutrient systems, reduced tillage, use of farmyard manure rather than chemicals, etc. These are proven to be beneficial, increase production and have a low impact on food security. The government of Nepal endorsed the soil and watershed conservation act in 1983, with its less proper implementation in the practical field needs to be revised. Subsequently poor soil management practices have significantly alluded the soil quality and crop productivity, steps are needed instantaneously to reverse the decreasing trends in crop production, taking sustainable soil management practices to ensure food security. Scientists or the Government of Nepal have to do time-to-time monitoring or evaluation of applied scientific methods like remote sensing, automatic monitoring, or assessment of various parameters like carbon sequestration, soil fertility, potential etc.
Gene architecture is a determinant of the transcriptional response to bulky DNA damages
Authors: Merav May , Bitensky Elnatan M , Heilbrun Elisheva E , Hacohen Tamar , Kirshenbaum Ayala , Golan-Berman Hadar , Cohen Yuval , Adar Sheera
Published: January 2024

Bulky DNA damages block transcription and compromise genome integrity and function. The cellular response to these damages includes global transcription shutdown. Still, active transcription is necessary for transcription-coupled repair and for induction of damage-response genes. To uncover common features of a general bulky DNA damage response, and to identify response-related transcripts that are expressed despite damage, we performed a systematic RNA-seq study comparing the transcriptional response to three independent damage-inducing agents: UV, the chemotherapy cisplatin, and benzo[a]pyrene, a component of cigarette smoke. Reduction in gene expression after damage was associated with higher damage rates, longer gene length, and low GC content. We identified genes with relatively higher expression after all three damage treatments, includingNR4A2, a potential novel damage-response transcription factor. Up-regulated genes exhibit higher exon content that is associated with preferential repair, which could enable rapid damage removal and transcription restoration. The attenuated response to BPDE highlights that not all bulky damages elicit the same response. These findings frame gene architecture as a major determinant of the transcriptional response that is hardwired into the human genome.
Development of International Chinese Language Education in Iran: An Analysis in the Context of Iran’s Foreign Language Policy Characteristics
Authors: Qi Ming , Wang Xinhua
Published: January 2024

This paper focuses on examining the relevant policies concerning Chinese language education within Iran’s foreign language education policy framework from the perspective of its historical context. By analyzing the characteristics of Iran’s foreign language policy and the current situation of Chinese language teaching in Iran, this paper studies the future development of international Chinese language education in Iran.
Design and Implementation of Vocational English Teaching from the Perspective of Curriculum Ideology and Politics: Taking “English for Careers” as an Example
Authors: Qu Renxiong
Published: January 2024

Based on the ideological and political perspective of the curriculum, this paper explores the design and implementation of English teaching in higher vocational colleges. Through the effective integration of ideological and political elements, this paper aims to cultivate students’ English application ability and professional quality, improve students’ comprehensive quality and social responsibility, and at the same time, innovate teaching methods and means, adapt to the needs of different industries and professions, and stimulate students’ learning interest and participation. This study provides some useful guidelines for enhancing the quality of vocational English teaching.
Education and Ecological Innovation Empowered by Technology: Innovation Practices in Inner Mongolia Universities
Authors: Yu Yan-Dong , Zainal Abidin Noraini Binti Hj.
Published: January 2024

This study aims to conduct a thorough analysis of the core elements of educational innovation in Inner Mongolian universities and their mechanisms for enhancing educational quality. By examining technological applications, innovative teaching models, and the educational ecosystem, this paper explores the ways in which technological empowerment enhances students’ learning experiences, the impact of innovative teaching models on educational quality, and the practical outcomes of ecological innovation theory in education. Additionally, relevant recommendations are provided for the future development trends of educational innovation in Inner Mongolian universities.
Research on the Teaching Optimization Path in Children’s Creative Art Curriculum Under the Perspective of “Sanquan Education”
Authors: Li Guiju
Published: January 2024

Children’s creative art curriculum is a professional course supported by art materials and techniques and facilitated through creative activities, aiming at cultivating students’ ability to organize creative art activities using various art materials and techniques. In light of the evolving focus in China’s colleges and universities from “what to know” to “how to apply,” the pivotal question for educators is how to maximize the value of children’s creative art curriculum. Based on this, this article takes “Sanquan education” as the starting point, combines factual and theoretical arguments, and analyzes the teaching optimization path of children’s creative art curriculum under the perspective of Sanquan education, to improve the quality and efficiency of teaching.
Innovative Research on Funding and Educating People in Applied Colleges and Universities Under the Perspective of Labor Education
Authors: Li Yuxuan
Published: January 2024

As an important part of the “Five Education,” labor education is a practical activity for cultivating labor values, labor skills, and labor spirit (also named craftsman spirit). This article points out the importance of integrating labor education into the process of “funding and educating people” in applied colleges and universities. It also explores the role of labor education as a starting point from the three aspects of labor values, labor skills, and labor spirit. It provides an innovative path for applied colleges to fund and educate people.
Integration of the Sunshine Sports Concept in Taekwondo Teaching in Colleges and Universities
Authors: Jia Tao
Published: January 2024

Sunshine Sports has played a significant role in promoting the teaching of Taekwondo in colleges and universities. By analyzing the connection between the Sunshine Sports concept and Taekwondo teaching, the characteristics of the Sunshine Sports concept in Taekwondo teaching in colleges and universities are discussed. This article expounds on the influencing factors in implementing the Sunshine Sports concept and discusses how to carry out scientific and reasonable teaching methods.
The Application of the Constructivism Theory in Enhancing Classroom Teaching
Authors: Zhu Lichao , Atompag Sheryl M.
Published: January 2024

As China’s education develops, the innovation of curriculum teaching mode has been increasingly emphasized, and the theory of constructivism has become a popular topic in educational research. The purpose of this article is to elucidate the theoretical implications of constructivism by examining the psychological mechanisms involved in individual constructivist activities. From setting learning objectives, researching problems, learning to present ideas, reflecting and evaluating, etc., this paper expounds on the application of constructivism theory in curriculum teaching. Besides, strategies for implementing the constructivism theory in curriculum teaching are also proposed, so as to promote autonomous learning and the sustainable development of students.
Research on Digital Practical Training Teaching Under the Background of “Internet +”: Taking the “Front Office Service” Course as an Example
Authors: Cui Lin
Published: January 2024

This article aims to explore the application of digitalization in practical training teaching under the background of “Internet +” by taking the teaching of “Front Office Service” in the hotel management and digital operation major as an example. By using digital teaching methods, tools, and practical training methods, this study analyzes the impact of digital practical training teaching on students’ mastery of front office service skills as well as explores the ways to implement digital practical training teaching. The research results show that digital practical training teaching can effectively improve students’ learning effects and comprehensive quality, and simultaneously has positive significance for cultivating comprehensive hotel management talents that adapt to the needs of the “Internet +” era.