bluuebunny/crossref_metadata_2025 huggingface dataset:
Physical and Sedentary Activity Patterns in Youths with Autism Spectrum Disorder
Authors: Pan Chien-Yu , Tsai Chia-Liang , Chen Fu-Chen , Chow Bik C. , Chen Chih-Chia , Chu Chia-Hua
Published: February 2021

Little is known about the patterns of sedentary behavior and physical activity (PA) within different school levels (i.e., primary school and secondary school) and on different day types (i.e., weekdays and weekend days) among youths with autism spectrum disorder (ASD). The sample was recruited from one city in Taiwan. A total of 68 male youths with ASD, aged 6–17 years, participated in the study. PA was assessed using an ActiGraph accelerometer, and sedentary behaviors (i.e., TV viewing, computer use, and reading time) were determined using a self-report log. The main findings were that (a) primary school youths with ASD were more active than secondary school youths with ASD on both weekdays and weekend days, but primary school youths with ASD also had more sedentary time than did secondary school youths with ASD on both weekdays and weekend days; (b) secondary school youths with ASD were more active but also more sedentary on weekdays compared with weekend days, but they had more screen use on weekend days compared with on weekdays. Future interventions are required to decrease sedentary behavior and increase PA to improve the health of these youths according to school level and day of the week.
Emotional Eating in Adults: The Role of Sociodemographics, Lifestyle Behaviors, and Self-Regulation—Findings from a U.S. National Study
Authors: Elran Barak Roni , Shuval Kerem , Li Qing , Oetjen Reid , Drope Jeffrey , Yaroch Amy L. , Fennis Bob M. , Harding Matthew
Published: February 2021

Background: Emotional eating, the tendency to overeat in response to negative emotions, has been linked to weight gain. However, scant evidence exists examining the prevalence and correlates of emotional eating among large samples of adults in the United States (U.S.). Hence, we examine the relationship among individual and socioeconomic factors, health behaviors, and self-regulation with emotional eating patterns among U.S. adults. Methods: Cross-sectional analysis of 5863 Family Health Habits Survey participants. Multivariable, ordered, logistic regression was employed to examine the relationship between the frequency of the desire to eat when emotionally upset (never, rarely, sometimes, often, and very often) and the independent variables. Results: Analysis reveals that 20.5% of the sample tended to emotionally eat often or very often. Being female, non-Hispanic White, and of younger age were all related to a higher likelihood of emotional eating. Additionally, inability to delay gratification (impatience) was related to an 18% increased likelihood (95% confidence interval (CI) 1.05–1.33) for emotional eating. Finally, emotional eating was significantly related to more frequent fast-food consumption. Conclusions: Program planners might need to develop targeted interventions aimed at enhancing emotional regulation skills while addressing these less healthful behaviors (e.g., fast-food intake) with the goal of obesity and chronic disease prevention.
Social–Emotional Competence and Academic Achievement of Nursing Students: A Canonical Correlation Analysis
Authors: Kim Sun-Hee , Shin Sujin
Published: February 2021

This study was conducted to investigate the correlations between social–emotional competence (SEC) and academic achievement (AA) among nursing students and to compare students’ level of each core skill of SEC (critical thinking disposition, self-directed learning, creativity, emotional intelligence, problem-solving, and collaboration) and academic achievement (clinical performance and subjective academic achievement). A cross-sectional design was adapted. Data were collected from 195 nursing students in the junior and senior years who had participated in clinical practicum from four universities in South Korea. General characteristics, levels of critical thinking disposition, self-directed learning, creativity, emotional intelligence, problem-solving, collaboration, and academic achievement were collected via self-reported questionnaire. Canonical correlation analysis was performed to evaluate the relationship between SEC and AA. The canonical correlation coefficient between SEC and AA was 0.762. Critical thinking disposition (Rs = 0.89), problem-solving (Rs = 0.86), and cooperation (Rs = 0.80) made the most important contributions to SEC. Clinical performance (Rs = 0.95) and subjective AA (Rs = 0.57) were correlated with AA. SEC should be addressed to improve the AA of nursing students. All core skills of SEC should be regularly promoted. It is particularly urgent for nursing students to improve their creativity.
Telehealth Use in Geriatrics Care during the COVID-19 Pandemic—A Scoping Review and Evidence Synthesis
Authors: Doraiswamy Sathyanarayanan , Jithesh Anupama , Mamtani Ravinder , Abraham Amit , Cheema Sohaila
Published: February 2021

Introduction: Globally, the COVID-19 pandemic has affected older people disproportionately. Prior to the pandemic, some studies reported that telehealth was an efficient and effective form of health care delivery, particularly for older people. There has been increased use of telehealth and publication of new literature on this topic during the pandemic, so we conducted a scoping review and evidence synthesis for telehealth use in geriatric care to summarize learning from these new data. Methods: We searched PubMed, Embase, and the World Health Organization’s COVID-19 global research database for articles published between 1 January and 20 August 2020. We included 79 articles that met our inclusion criteria. The information collected has been synthesized and presented as descriptive statistics. Strengths, weaknesses, opportunities, and threats (SWOT) have also been discussed. Results: The articles included in our review provide some evidence of effective provision of preventive, curative, and rehabilitative telehealth services for older people, but they highlight a greater focus on curative services and are mostly concentrated in high-income countries. We identified convenience and affordability as the strengths of telehealth use in geriatric care. Weaknesses identified include the inability of telehealth to cater to the needs of older people with specific physical and cognitive limitations. While the threats of increasing inequity and the lack of standardization in the provision of age-friendly telehealth services remain, we identified opportunities for technologic advancements driven by simplicity and user-friendliness for older people. Conclusion: Telehealth offers futuristic promise for the provision of essential health care services for older people worldwide. However, the extent of these services via telehealth appears to be currently limited in low and low-middle income countries. Optimizing telehealth services that can be accessed by older people requires greater government investments and active engagement by broader participation of older people, their caregivers, physicians and other health care providers, technology experts, and health managers.
Examining Public Concerns and Attitudes toward Unfair Events Involving Elderly Travelers during the COVID-19 Pandemic Using Weibo Data
Authors: Liu Xinghua , Ye Qian , Li Ye , Fan Jing , Tao Yue
Published: February 2021

The Chinese government has launched a digital health code system to detect people potentially exposed to the coronavirus 2019 (COVID-19) disease and to curb its spread. Citizens are required to show the health code on their smartphones when using public transport. However, many seniors are not allowed to use public transport due to their difficulties in obtaining health codes, leading to widespread debates about these unfair events. Traditionally, public perceptions and attitudes toward such unfair events are investigated using analytical methods based on interviews or questionnaires. This study crawled seven-month messages from Sina Weibo, the Chinese version of Twitter, and developed a hybrid approach integrating term-frequency–inverse-document-frequency, latent Dirichlet allocation, and sentiment classification. Results indicate that a rumor about the unfair treatment of elderly travelers triggered public concerns. Primary subjects of concern were the status quo of elderly travelers, the provision of transport services, and unfair event descriptions. Following the government’s responses, people still had negative attitudes toward transport services, while they became more positive about the status quo of elderly travelers. These findings will guide government authorities to explore new forms of automated social control and to improve transport policies in terms of equity and fairness in future pandemics.
Burnout, Positivity and Passion in Young Mexican Athletes: The Mediating Effect of Social Support
Authors: Martínez-Alvarado Julio Román , Aguiar Palacios Luis Horacio , Chávez-Flores Yolanda Viridiana , Berengüí Rosendo , Asadi-González Ahmed Ali , Magallanes Rodríguez Ana Gabriela
Published: February 2021

The burnout syndrome is a negative experience for athlete development and it has been demonstrated that it gets worse when a sport is practiced in an obsessive way. Interventions with a positive view towards sports could be a protective factor to boost the athlete’s wellbeing. The aim of the present study was to analyse the mediator effect from social support, the relationship between the burnout, positivity and passion in young Mexican athletes. The sample was composed by 452 Mexican athletes, males and females (women 45%), from 12 to 18 years of age (M = 16.29, SD = 1.66). Participants answered the Athlete Burnout Questionnaire, The Scale of the Social Support Perceived by Athletes, the Passion Scale and the Positivity Scale. The results of structural equation modeling showed a good adjustment model (χ2 = 889.213; df = 274; χ2/df = 3.245; p ˂ 0.01; CFI = 0.93; TLI = 0.91; IFI = 0.94; NFI = 0.91; RMSEA = 0.07). The harmonious passion presented direct and indirect effects on the burnout, being the perceived social support the mediator variable of the indirect effect. The positivity resulted positive predictor from the social support (β = 0.714, p ˂ 0.001) and social support predicted the burnout (β = −0.270, p ˂ 0.005). The obsessive passion had a direct effect over burnout (β = 0.627, p ˂ 0.001). Developing negative commitments to sports could be an indicator of a greater risk of experiencing individual conflicts that lead to sports burnout.
Influence of Resistance Training on Gait & Balance Parameters in Older Adults: A Systematic Review
Authors: Keating Christopher J. , Cabrera-Linares José Carlos , Párraga-Montilla Juan A. , Latorre-Román Pedro A. , del Castillo Rafael Moreno , García-Pinillos Felipe
Published: February 2021

In this work we aimed to perform a systematic review of randomized controlled trials within an aging population that investigated the general impacts of a resistance training (RT) protocol on key outcome measures relating to gait and/or balance. Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement guidelines, two electronic databases (PubMed, and Scopus) were searched for randomized controlled trials that measured at least one key outcome measure focusing on gait and/or balance in older adults. 3794 studies were identified, and after duplicates were removed, 1913 studies remained. 1886 records were removed due to the abstract not meeting the inclusion criteria. 28 full-text articles were assessed further, and 20 of the articles were identified as meeting the criteria for inclusion. The remaining 20 studies were assessed for quality using the Physiotherapy Evidence Database (PEDro) scale; 12 studies remained and were included in this systematic review. Our review suggests that RT has a positive effect on both gait and balance in an elderly population. RT improves gait, specifically straight-line walking speed in older adults. RT is an adequate training method to improve balance in an aging population. Improvements in strength, attributed to RT, may allow for greater autonomy and independence to carry out activities of daily living as we age.
Parental Beliefs about Childhood and Adolescence from a Longitudinal Perspective
Authors: Ridao Pilar , López-Verdugo Isabel , Reina-Flores Carmen
Published: February 2021

Research into family context as a socializing agent points to the need to take parental beliefs into account due to the role they play in both parenting strategies and, ultimately, in the psychosocial adjustment of children and adolescents. The present study aims to explore possible relationships between parental beliefs about childhood and adolescence from a longitudinal and qualitative perspective. The beliefs held by parents of teenagers about adolescence are compared with those they hold about childhood at that same moment, and the evolution of these ideas is charted over the course of 16 years as their children grow. A total of 102 parents participated in the longitudinal study. They completed two types of semi-structured interviews: one of them throughout the entire study period and the other once their children became teenagers. The results reveal an association between the type of beliefs parents hold about childhood and their perception of adolescence, and they indicate that these ideas change over time as more adjusted and modern beliefs about child development correlate with a more positive perception of adolescence. These results are interpreted from the perspective of their influence on beliefs about parenting styles, reflecting what is reported in the recent literature regarding the most successful styles for fostering children’s and adolescents’ psychosocial adjustment.
Mapping the Worldwide Trends on Energy Poverty Research: A Bibliometric Analysis (1999–2019)
Authors: Xiao Yiming , Wu Han , Wang Guohua , Mei Hong
Published: February 2021

Energy poverty is one of the main challenges facing humanity in the 21st century. Research on energy poverty is becoming a common focus of scholars in many areas. Bibliometrics can help researchers dig deep into the information of specific research fields from a quantitative perspective. In this study, we collected 1018 research papers in the field of energy poverty published in the period 1999–2019 from the Web of Science databases and conducted a bibliometric analysis on them. Cleaning and screening of sample papers, matrix construction, and visualization were performed using Bibliometrix, VOSviewer, and HistCite, summarizing the internal and external characteristics of the papers. With regard to external characteristics, a total of 982 research institutions in 80 regions conducted research in this field. There is extensive cooperation between the countries, and the UK, the USA, Australia, and Italy play the most active role in the cooperation network. With regard to internal characteristics, we found the two most representative citation paths: one path starts from the concerns of energy-poor groups and stops at an ethical discussion on energy poverty; the second path is based on the existing technological path, continuously developing coping policies, evaluation methods, and a conceptual framework for dealing with energy poverty. Furthermore, through coupling analysis, we discovered four focuses of energy poverty research: improvement of definition, improvement of evaluation methods, effects of coping policy, and energy justice. Through a comprehensive analysis of existing papers, this paper reveals some limitations of previous studies and recommends some promising directions for future research on energy poverty.
The Relegated Goal of Health Institutions: Sexual and Reproductive Health
Authors: Martínez-Galiano Juan Miguel , Delgado-Rodríguez Miguel
Published: February 2021

Sexual and reproductive health does not always receive the attention it deserves and frequently is not supported with the necessary resources to guarantee its maintenance [...]
Coping, Resilience, and Perceived Stress in Individuals with Internet Gaming Disorder in Taiwan
Authors: Lin Pai-Cheng , Yen Ju-Yu , Lin Huang-Chi , Chou Wei-Po , Liu Tai-Ling , Ko Chih-Hung
Published: February 2021

Aim: Gaming escapism is an essential factor for developing internet gaming disorder (IGD). We evaluated coping strategies, resilience, stress, and depression in individuals with IGD. Methods: We included 69 participants with IGD and 138 controls (69 regular gamers and other non-gamers) in Taiwan. The self-reported coping strategies, coping stress with gaming, resilience, perceived stress, and depression were assessed. Results: Participants with IGD had higher dysfunctional coping, coping stress by gaming, perceived stress, and depression, as well as lower problem-focused coping and resilience. Regression analysis revealed that coping by gaming was associated with dysfunctional coping mechanisms, particularly venting and self-distraction. Compared with participants with adequate resilience, those with lower resilience had higher perceived stress, depression, and coping by gaming, and lower problem-focused and emotion-focused coping. Dysfunctional coping and coping by gaming were associated with perceived stress and depression in both IGD and control groups. Problem-focused coping was negatively associated with perceived stress and depression in controls. Conclusion: Individuals with IGD had higher perceived stress and depression, as they were more likely to cope with stress by dysfunctional coping and gaming and less likely to try problem-focused coping, particularly those with lower resilience. Interventions for IGD should promote problem-focused coping, such as active coping and planning strategies, particularly among those with lower resilience.
Transition of Radioactive Cesium Deposition in Reproductive Organs of Free-Roaming Cats in Namie Town, Fukushima
Authors: Fujishima Yohei , Kino Yasushi , Ono Takumi , Goh Valerie Swee Ting , Nakata Akifumi , Ariyoshi Kentaro , Kasai Kosuke , Toyoda Tadashi , Akama Toru , Tazoe Hirofumi , Yamada Masatoshi , Yoshida Mitsuaki A. , Miura Tomisato
Published: February 2021

We investigated the internal contamination by radioactive cesium associated with the FDNPP accident, in the testes or uterus and ovaries of free-roaming cats (Felis silvestris catus), which were protected by volunteers in the Namie Town, Fukushima. A total of 253 samples (145 testes and 108 uterus and ovaries) obtained from adult cats and 15 fetuses from 3 pregnant female cats were measured. Free-roaming cats in Namie Town had a higher level of radioactive contamination in comparison to the control group in Tokyo, as the 134Cs + 137Cs activity concentration ranged from not detectable to 37,882 Bq kg−1 in adult cats. Furthermore, the radioactivity in the fetuses was almost comparable to those in their mother’s uterus and ovaries. The radioactivity was also different between several cats protected in the same location, and there was no significant correlation with ambient dose-rates and activity concentrations in soil. Moreover, radioactive cesium levels in cats decreased with each year. Therefore, it is likely that decontamination work in Namie Town and its surroundings could affect radioactive cesium accumulation, and thus possibly reduce the internal radiation exposure of wildlife living in contaminated areas. It is hence necessary to continue radioactivity monitoring efforts for the residents living in Namie Town.
Blind Deconvolution Based on Compressed Sensing with bi-l0-l2-norm Regularization in Light Microscopy Image
Authors: Kim Kyuseok , Kim Ji-Youn
Published: February 2021

Blind deconvolution of light microscopy images could improve the ability of distinguishing cell-level substances. In this study, we investigated the blind deconvolution framework for a light microscope image, which combines the benefits of bi-l0-l2-norm regularization with compressed sensing and conjugated gradient algorithms. Several existing regularization approaches were limited by staircase artifacts (or cartooned artifacts) and noise amplification. Thus, we implemented our strategy to overcome these problems using the bi-l0-l2-norm regularization proposed. It was investigated through simulations and experiments using optical microscopy images including the background noise. The sharpness was improved through the successful image restoration while minimizing the noise amplification. In addition, quantitative factors of the restored images, including the intensity profile, root-mean-square error (RMSE), edge preservation index (EPI), structural similarity index measure (SSIM), and normalized noise power spectrum, were improved compared to those of existing or comparative images. In particular, the results of using the proposed method showed RMSE, EPI, and SSIM values of approximately 0.12, 0.81, and 0.88 when compared with the reference. In addition, RMSE, EPI, and SSIM values in the restored image were proven to be improved by about 5.97, 1.26, and 1.61 times compared with the degraded image. Consequently, the proposed method is expected to be effective for image restoration and to reduce the cost of a high-performance light microscope.
Mechanisms and Empirical Modeling of Evaporation from Hardened Surfaces in Urban Areas
Authors: Zhou Jinjun , Liu Jiahong , Chu Qi , Wang Hao , Shao Weiwei , Luo Zhuoran , Zhang Yongxiang
Published: February 2021

Urban evaporation, as an essential part of local water vapor resources in urban areas, has often been underestimated. One possible reason is that the evaporation of urban hardened surfaces is seldom considered and poorly understood in urban evaporation estimation. This study focused on the mechanisms and calculation of evaporation on hardened surfaces in urban areas. Experimental monitoring was used to monitor the processes and characteristics of evaporation on hardened surfaces. Mathematical models based on water quantity constraints were built to calculate evaporation of hardened surfaces. The results showed that: The interception abilities for rainwater and rainfall days of impervious hardened surfaces determine their evaporated water amount, which means no water, no evaporation for the impervious surfaces. The greater evaporation of artificial sprinkling on roads happened in fewer days of rainfall and frost. The evaporation of pervious hardened ground is continuous compared to the impervious surface. Its soil moisture in the sub-layer of permeable concrete decreases periodically with a period of one day. The evaporation of hardened surfaces occupies 16–29% of the total amount of evaporation in the built-up areas in cities. Therefore, the hardened surface evaporation has great significance on the urban hydrological cycle and urban water balance.
Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and Obesity in Five-Year-Olds in the CHAMACOS Cohort
Authors: Berger Kimberly , Hyland Carly , Ames Jennifer L. , Mora Ana M. , Huen Karen , Eskenazi Brenda , Holland Nina , Harley Kim G.
Published: February 2021

Exposures to phthalates, parabens, and other phenols are often correlated due to their ubiquitous use in personal care products and plastics. Examining these compounds as a complex mixture may clarify inconsistent relationships between individual chemicals and childhood adiposity. Using data from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a longitudinal cohort of children in Salinas Valley, California (n = 309), we examined biomarkers of 11 phthalate metabolites and 9 phenols, including several parabens and bisphenol A, measured in maternal urine at two time points during pregnancy. We measured child height and weight at age five to calculate the body mass index (BMI) z-scores and overweight/obesity status. The association between prenatal urinary concentrations of biomarkers with the childhood BMI z-score and overweight/obesity status was analyzed using single-pollutant models and two mixture methods: Bayesian hierarchical modeling (BMH) and Bayesian kernel machine regression (BKMR). Urinary concentrations of monoethyl phthalate, monocarboxy-isononly phthalate (metabolites of diethyl phthalate and di-isodecyl phthalate, respectively), and propylparaben were consistently associated with an increased BMI z-score and overweight/obesity status across all modeling approaches. Higher prenatal exposures to the cumulative biomarker mixture also trended with greater childhood adiposity. These results, robust across two methods that control for co-pollutant confounding, suggest that prenatal exposure to certain phthalates and parabens may increase the risk for obesity in early childhood.
Predictors of Sports Gambling among College Students: The Role of the Theory of Planned Behavior and Problem Gambling Severity
Authors: Wang Xin , Won Doyeon , Jeon Hyung Sang
Published: February 2021

The current study investigated what influences college students’ behavioral intention and behavior towards sports gambling using the theory of planned behavior (TPB) as a theoretical framework. The study also explored the moderation effect of problem gambling severity in the relationships between TPB determinants, behavioral intention, and sports gambling behavior. Data were collected from 334 college students from four different universities in the U.S. and analyzed through partial least squares structural equation modeling (PLS-SEM) and multi-group analysis. The results indicated that attitude was the most critical determinant of college students’ sports gambling intentions, followed by the subjective norms, while both behavioral intention and perceived behavioral control were significant predictors of sports gambling behavior. The study also found some meaningful moderation effects of problem gambling severity. Subjective norms were influential on college students with greater problem gambling severity, while attitude was the strongest predictor of recreational sports gamblers. Suggestions on prevention and treatment programs regarding sports gambling and problem gambling are discussed.
Risky Behaviour among Nurses in Poland: An Analysis of Nurses’ Physical Condition, Mental Health, and Resilience
Authors: Gieniusz-Wojczyk Lucyna , Dąbek Józefa , Kulik Halina
Published: February 2021

Background: Nursing is a profession where staff are exposed to chronic stress. Mental resilience plays a significant role in the process of coping with these challenges. The aim of this study was to assess nurses’ mental and physical wellbeing, as well as resilience, by taking into account the occurrence of risky behaviour among nurses in Poland. Methods: A descriptive study was carried out between June 2017 and May 2018 among nurses (n = 1080) employed in primary healthcare or in training centres in Silesia, Poland. Data were obtained from a number of questionnaires. Results: Over half of the nurses (n = 735; 68%) had an average psychophysical mood level resulting from stress, and 179 (16.6%) nurses had a low psychophysical mood. Those with a lower psychophysical mood showed a greater tendency towards developing improper eating habits (r = −0.23; p < 0.001). Most nurses had an average (n = 649; 60.1%) or low (n = 255; 23.6%) level of resilience. Higher resilience levels were observed in nurses aged over 30 years (p = 0.004) and in those with additional employment (p = 0.008). High resilience was associated with a lower intensity of risky behaviour. Conclusion: Most nurses in Poland display average and low levels of resilience, which can have unfavourable consequences for their health.
The Recreational Trail of the El Caminito del Rey Natural Tourist Attraction, Spain: Determination of Hikers’ Flow
Authors: Gea-García Gemma María , Fernández-Vicente Carmelo , Barón-López Francisco J. , Miranda-Páez Jesús
Published: February 2021

Hiking is a very popular outdoor activity, and has led to an exponential increase in the number of visitors to natural spaces. The objective of this study was to analyze the circulation pattern of visitors to the Caminito del Rey trail, based on the three zones into which the trail can be divided. The sample consisted of 1582 hikers distributed into three different profiles. Of these, 126 utilized an eye-tracking device during the hike, while, for the rest (1456), only their travel speed along the trail was recorded. The use of eye tracking devices identified a greater number of interesting landscapes located in zones 1 and 3 of the trail, and it was observed that the mean travel speed was greater for zone 2 (42.31 m/min) (p < 0.01). Additionally, when the three different visitor profiles were analyzed, significant differences were found between the mean travel speeds according to sectors (p < 0.05). This information is crucial for more efficient management of the trail, as it allows for the development of measures to control and regulate the flow of visitors according to zone, and the design of additional strategies to increase the awareness of the hiker about specific areas of the hike.
Ant Guild Identity Determines Seed Fate at the Post-Removal Seed Dispersal Stages of a Desert Perennial
Authors: Ben-Zvi Gilad , Seifan Merav , Giladi Itamar
Published: February 2021

Ants play a dual role in their interaction with plant seeds. In deserts, the consumption of seeds by granivorous ants is common, whereas mutualistic seed dispersal, often associated with scavenging ants, is rarely documented. We evaluated the contribution of both ant guilds to efficient seed dispersal of an ant-dispersed plant, Sternbergia clusiana, in a desert ecosystem. We presented seed to colonies of three species of desert ants from the Cataglyphis (scavengers) and Messor (granivorous) genera. We recorded seed consumption, ejection from the nest, and seed transportation to potentially beneficial microhabitats. We evaluated microhabitat quality by testing the association between habitat types and the plant at various life stages. As expected, granivores mainly consumed the seeds, whereas scavengers consumed the elaiosome (seed appendage serving as a reward), but left the seeds intact. Moreover, scavenging ants relocated the seeds much further than granivores, mainly to shrub patches. The disproportional distribution of the plant under shrubs at several life stages suggests that this microhabitat is beneficial for the plant. Overall, while granivores seem to mainly harm seed dispersal, we provide the first evidence for the beneficial contribution of scavenging ants in deserts, showing they exhibit the same suite of characteristics that render them efficient seed dispersers in other ecosystems.
Nutrient Imbalance of the Host Plant for Larvae of the Pale Grass Blue Butterfly May Mediate the Field Effect of Low-Dose Radiation Exposure in Fukushima: Dose-Dependent Changes in the Sodium Content
Authors: Sakauchi Ko , Taira Wataru , Toki Mariko , Tsuhako Masakazu , Umetsu Kazuo , Otaki Joji
Published: February 2021

The pale grass blue butterfly Zizeeria maha is sensitive to low-dose radioactive pollution from the Fukushima nuclear accident in the field but is also highly tolerant to radioactive cesium (137Cs) in an artificial diet in laboratory experiments. To resolve this field-laboratory paradox, we hypothesize that the butterfly shows vulnerability in the field through biochemical changes in the larval host plant, the creeping wood sorrel Oxalis corniculata, in response to radiation stress. To test this field-effect hypothesis, we examined nutrient contents in the host plant leaves from Tohoku (mostly polluted areas including Fukushima), Niigata, and Kyushu, Japan. Leaves from Tohoku showed significantly lower sodium and lipid contents than those from Niigata. In the Tohoku samples, the sodium content (but not the lipid content) was significantly negatively correlated with the radioactivity concentration of cesium (137Cs) in leaves and with the ground radiation dose. The sodium content was also correlated with other nutrient factors. These results suggest that the sodium imbalance of the plant may be caused by radiation stress and that this nutrient imbalance may be one of the reasons that this monophagous butterfly showed high mortality and morphological abnormalities in the field shortly after the accident in Fukushima.
Estimating Potential Distribution of Sweetgum Pest Acanthotomicus suncei and Potential Economic Losses in Nursery Stock and Urban Areas in China
Authors: Li You , Wan Yuxuan , Lin Wei , Ernstsons A. Simon , Gao Lei
Published: February 2021

American sweetgum Liquidambar styraciflua (Altingiaceae) was first introduced to China over 60 years ago. It is an important tree species for increasing landscape value and promoting afforestation in urbanized areas of eastern China in the past 20 years. Sweetgum inscriber Acanthotomicus suncei (Coleoptera: Curculionidae) is a local bark beetle pest and lethal to the introduced American sweetgum. To provide preliminary estimates of the potential economic losses caused by the sweetgum inscriber, a field investigation was conducted to survey the beetles’ natural distribution in China. Based on field collections, potential distribution was predicted using Maxent. All nurseries stocking American sweetgum were in the high and very high suitability area of sweetgum inscriber. Additionally, we employed a model of direct loss incorporating tree and removal cost. A questionnaire was sent to maintenance companies, growers, and gardener associations for tree removal prices. We estimated the removal cost of each tree. In addition, the market price and inventory were also gained from telephone interview. Our economic analysis indicates that if sweetgum inscriber were to become established in the main American sweetgum business, the potential losses of nursery stock and urban area could range from USD 12.81 to 14.41 million.
Laboratory and Instrumental Risk Factors Associated with a Sudden Cardiac Death Prone ECG Pattern in the General Population: Data from the Brisighella Heart Study
Authors: Coppola Pierangelo , Cicero Arrigo , Fogacci Federica , D’Addato Sergio , Bacchelli Stefano , Borghi Claudio ,   on behalf of the Brisighella Heart Study Group
Published: February 2021

Sudden cardiac death (SCD) remains a daunting problem and a major public health issue. We applied the validated Electrocardiogram (ECG) score to the Brisighella Heart Study (BHS) cohort, in order to verify if there were also other recognized laboratory and instrumental risk factors for cardiovascular disease associated with a sudden death risk-prone pattern. We examined the ECG traces of 1377 participants of the 2016 BHS survey and identified 33 subjects at high risk for SCD (while 1344 subjects had no cumulative ECG abnormalities). Serum uric acid (SUA) and carotid-femoral pulse wave velocity (cfPWV) values were significantly higher in the high-risk cohort (p < 0.05) and were both independently associated with the presence of ECG abnormalities [Odd ratio (OR) = 2.14, p < 0.05–OR = 1.23, p < 0.05, respectively]. A similar independent correlation was found with long-term non-steroid anti-inflammatory drugs (NSAIDs) use, more widespread among high-risk subjects (OR = 1.19, p < 0.05). Conversely, the analysis did not show any significant association with impaired renal function (p = 0.09). This study showed that long-term NSAID use and high SUA and cfPWV values are independent risk factors for ECG abnormalities predictive of SCD. These findings herald the need for further prospective research to identify the optimal combination of SCD risk markers in order to prevent fatal events.
Impact of Adjuvant Chemotherapy on Survival of Patients with Advanced Residual Disease at Radical Cystectomy following Neoadjuvant Chemotherapy: Systematic Review and Meta-Analysis
Authors: Krajewski Wojciech , Nowak Łukasz , Moschini Marco , Poletajew Sławomir , Chorbińska Joanna , Necchi Andrea , Montorsi Francesco , Briganti Alberto , Sanchez-Salas Rafael , Shariat Shahrokh F , Palou Juan , Babjuk Marek , Teoh Jeremy YC , Soria Francesco , Pradere Benjamin , Ornaghi Paola Irene , Pawlak Aleksandra , Dembowski Janusz , Zdrojowy Romuald
Published: February 2021

Background: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) with pelvic lymph-node dissection is the standard treatment for cT2-4a cN0 cM0 muscle-invasive bladder cancer (MIBC). Despite the significant improvement of primary-tumor downstaging with NAC, up to 50% of patients are eventually found to have advanced residual disease (pT3–T4 and/or histopathologically confirmed nodal metastases (pN+)) at RC. Currently, there is no established standard of care in such cases. The aim of this systematic review and meta-analysis was to assess differences in survival rates between patients with pT3–T4 and/or pN+ MIBC who received NAC and surgery followed by adjuvant chemotherapy (AC), and patients without AC. Materials and Methods: A systematic search was conducted in accordance with the PRISMA statement using the Medline, Embase, and Cochrane Library databases. The last search was performed on 12 November 2020. The primary end point was overall survival (OS) and the secondary end point was disease-specific survival (DSS). Results: We identified 2124 articles, of which 6 were selected for qualitative and quantitative analyses. Of a total of 3096 participants in the included articles, 2355 (76.1%) were in the surveillance group and 741 (23.9%) received AC. The use of AC was associated with significantly better OS (hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.75–0.94; p = 0.002) and DSS (HR 0.56, 95% CI 0.32–0.99; p = 0.05). Contrary to the main analysis, in the subgroup analysis including only patients with pN+, AC was not significantly associated with better OS compared to the surveillance group (HR 0.89, 95% CI 0.58–1.35; p = 0.58). Conclusions: The administration of AC in patients with MIBC and pT3–T4 residual disease after NAC might have a positive impact on OS and DSS. However, this may not apply to N+ patients.
Sex Differences in the Effects of COPD on Incidence and Outcomes of Patients Hospitalized with ST and Non-ST Elevation Myocardial Infarction: A Population-Based Matched-Pair Analysis in Spain (2016–2018)
Authors: de-Miguel-Diez Javier , Jiménez-García Rodrigo , Hernandez-Barrera Valentín , Ji Zichen , de Miguel-Yanes José María , López-Herranz Marta , López-de-Andrés Ana
Published: February 2021

We aimed to compare the incidence, clinical characteristics, and outcomes of patients admitted with myocardial infarction (MI), whether ST elevation MI (STEMI) or non-ST elevation MI (NSTEMI), according to the presence of chronic obstructive pulmonary disease (COPD), and to identify variables associated with in-hospital mortality (IHM). We selected all patients with MI (aged ≥40 years) included in the Spanish National Hospital Discharge Database (2016–2018). We matched each patient suffering COPD with a non-COPD patient with identical age, sex, type of MI, and year of hospitalization. We identified 109,759 men and 44,589 women with MI. The MI incidence was higher in COPD patients (incident rate ratio (IRR) 1.32; 95% confidence interval (CI) 1.29–1.35). Men with COPD had higher incidence of STEMI and NSTEMI than women with COPD. After matching, COPD men had a higher IHM than non-COPD men, but no differences were found among women. The probability of dying was higher among COPD men with STEMI in comparison with NSTEMI (odds ratio (OR) 2.33; 95% CI 1.96–2.77), with this risk being higher among COPD women (OR 2.63; 95% CI 1.75–3.95). Suffering COPD increased the IHM after an MI in men (OR 1.14; 95% CI 1.03–1.27), but no differences were found in women. COPD women had a higher IHM than men (OR 1.19; 95% CI 1.01–1.39). We conclude that MI incidence was higher in COPD patients. IHM was higher in COPD men than in those without COPD, but no differences were found among women. Among COPD patients, STEMI was more lethal than NSTEMI. Suffering COPD increased the IHM after MI among men. Women with COPD had a significantly higher probability of dying in the hospital than COPD men.
A Novel Language Paradigm for Intraoperative Language Mapping: Feasibility and Evaluation
Authors: Rosengarth Katharina , Pai Delin , Dodoo-Schittko Frank , Hense Katharina , Tamm Teele , Ott Christian , Lürding Ralf , Bumes Elisabeth , Greenlee Mark W , Schebesch Karl Michael , Schmidt Nils Ole , Doenitz Christian
Published: February 2021

(1) Background—Mapping language using direct cortical stimulation (DCS) during an awake craniotomy is difficult without using more than one language paradigm that particularly follows the demand of DCS by not exceeding the assessment time of 4 s to prevent intraoperative complications. We designed an intraoperative language paradigm by combining classical picture naming and verb generation, which safely engaged highly relevant language functions. (2) Methods—An evaluation study investigated whether a single trial of the language task could be performed in less than 4 s in 30 healthy subjects and whether the suggested language paradigm sufficiently pictured the cortical language network using functional magnetic resonance imaging (fMRI) in 12 healthy subjects. In a feasibility study, 24 brain tumor patients conducted the language task during an awake craniotomy. The patients’ neuropsychological outcomes were monitored before and after surgery. (3) Results—The fMRI results in healthy subjects showed activations in a language-associated network around the (left) sylvian fissure. Single language trials could be performed within 4 s. Intraoperatively, all tumor patients showed DCS-induced language errors while conducting the novel language task. Postoperatively, mild neuropsychological impairments appeared compared to the presurgical assessment. (4) Conclusions—These data support the use of a novel language paradigm that safely monitors highly relevant language functions intraoperatively, which can consequently minimize negative postoperative neuropsychological outcomes.
Changes in Plasma Glial Fibrillary Acidic Protein in Children Receiving Sevoflurane Anesthesia: A Preliminary Randomized Trial
Authors: Kim Eun-Hee , Jang Young-Eun , Ji Sang-Hwan , Lee Ji-Hyun , Cho Sung-Ae , Kim Jin-Tae , Yoon Hyunyee , Kim Hee-Soo
Published: February 2021

We investigated changes in plasma glial fibrillary acidic protein concentration during sevoflurane anesthesia induction in children < 3 years old and determined the effect of co-administering dexmedetomidine. This preliminary randomized trial included 60 pediatric patients who received sevoflurane anesthesia for >3 h. Patients were assigned to dexmedetomidine or control groups at a 1:1 ratio. The primary outcome was changes in plasma glial fibrillary acidic protein concentration of dexmedetomidine and control groups over time. Fifty-five patients were included in the final analysis. The median (interquartile range (IQR)) of the plasma glial fibrillary acidic protein level was 387.7 (298.9–510.8) pg·mL−1 immediately after anesthetic induction, 302.6 (250.9–412.5) pg·mL−1 at 30 min, and 321.9 (233.8–576.2) pg·mL−1 at 180 min after the first sample. These values did not change over time (p = 0.759). However, plasma glial fibrillary acidic protein increased after 180 min of infusion of dexmedetomidine compared with values at 30 min infusion (p = 0.04, mean difference and 95% confidence interval of 221.6 and 2.2 to 441.0 pg·mL−1). In conclusion, three hours of sevoflurane anesthesia in pediatric patients < 3 years old did not provoke neuronal injury assessed by the plasma biomarker. Further studies regarding the effect of prolonged dexmedetomidine infusion on anesthetic neuronal injury are required.
Endometriosis and Risk of Adverse Pregnancy Outcome: A Systematic Review and Meta-Analysis
Authors: Breintoft Kjerstine , Pinnerup Regitze , Henriksen Tine Brink , Rytter Dorte , Uldbjerg Niels , Forman Axel , Arendt Linn Håkonsen
Published: February 2021

Background: This systematic review and meta-analysis summarizes the evidence for the association between endometriosis and adverse pregnancy outcome, including gestational hypertension, pre-eclampsia, low birth weight, and small for gestational age, preterm birth, placenta previa, placental abruption, cesarean section, stillbirth, postpartum hemorrhage, spontaneous hemoperitoneum in pregnancy, and spontaneous bowel perforation in pregnancy. Methods: We performed the literature review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), by searches in PubMed and EMBASE, until 1 November 2020 (PROSPERO ID CRD42020213999). We included peer-reviewed observational cohort studies and case-control studies and scored them according to the Newcastle–Ottawa Scale, to assess the risk of bias and confounding. Results: 39 studies were included. Women with endometriosis had an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth, compared to women without endometriosis. These results remained unchanged in sub-analyses, including studies on spontaneous pregnancies only. Spontaneous hemoperitoneum in pregnancy and bowel perforation seemed to be associated with endometriosis; however, the studies were few and did not meet the inclusion criteria. Conclusions: The literature shows that endometriosis is associated with an increased risk of gestational hypertension, pre-eclampsia, preterm birth, placenta previa, placental abruption, cesarean section, and stillbirth.
Estimating the Prevalence of Knee Pain and the Association between Illness Perception Profiles and Self-Management Strategies in the Frederiksberg Cohort of Elderly Individuals with Knee Pain: A Cross-Sectional Study
Authors: Ginnerup-Nielsen Elisabeth , Christensen Robin , Heitmann Berit L , Altman Roy D. , March Lyn , Woolf Anthony , Bliddal Henning , Henriksen Marius
Published: February 2021

Knee pain is an early sign of later incident radiographic knee osteoarthritis (OA). However, the prevalence of knee pain in the general population is unknown. Additionally, it is unknown how people with knee pain choose to self-manage the condition and if the perception of the illness affects these choices. In this study, 9086 citizens between 60–69 years old in the municipality of Frederiksberg, Copenhagen, Denmark, were surveyed, of which 4292 responded. The prevalence of knee pain was estimated, and associations between illness perceptions (brief illness perception questionnaire [B-IPQ]), self-management strategies, and knee symptoms were assessed. The prevalence of knee pain was 21.4% of which 40.5% reported to use no self-management strategies (non-users). These non-users perceived their knee pain as less threatening and reported less severe symptoms than users of self-management strategies. Further, we found that a more positive illness perception was associated with less severe knee symptoms. In conclusion, among Danes aged 60–69 years, the knee pain prevalence is 21.4%, of which 40.5% use no treatment and perceive the condition as non-threatening. These non-users with knee pain represent a subpopulation being at increased risk of developing knee OA later in life, and there is a potential preventive gain in identifying these persons.