bluuebunny/crossref_metadata_2025 huggingface dataset:
Composição química de Eichhornia crassipes (Mart) Solms, no sistema de Baías Chacororé-Sinhá Mariana Pantanal de Mato Grosso, Brasil
Authors: Nunes Josué Ribeiro da Silva , Silva Carolina Joana da
Published: January 2022

O Pantanal constitui-se na maior planície alagável do mundo, englobando um mosaico de diferentes habitats, sustentando rica biota aquática e terrestre. Este mosaico de habitats do Pantanal é bem representado no município de Barão de Melgaço pelo sistema de baías Chacororé-Sinhá Mariana, este sistema de baías, lagoas parentais do rio Cuiabá são reconhecidas pela sua produtividade aquática e beleza cênica. As macrófitas aquáticas são organismos extremamente abundantes no Pantanal sendo considerada a comunidade mais produtiva dos sistemas alagáveis, com grande capacidade de acumulação de biomassa e nutrientes. As coletas foram realizadas em três pontos de coleta, Baía Chacororé, Baía Sinhá Mariana e a transição entre elas. Este estudo teve como objetivo analisar a variação temporal e espacial dos principais nutrientes na biomassa de E. crassipes no Sistema de Baías Chacororé-Sinhá Mariana. Os resultados mostraram que a baía de Chacororé apresentou maior concentração de fósforo total, de conteúdo mineral, sódio, cálcio e potássio das estações de coleta amostradas na estiagem, também apresentou maior concentração de Nitrogênio total, mas na cheia. A maior concetração de magnésio foi obtida na cheia e na estação de coleta SMM. Esta pesquisa corrobora outros estudos realizados no Pantanal sobre a importância do pulso de inundação na variação temporal da concentração de nutrientes na biomassa de E. crassipes nas baías e evidência a heterogeneidade espacial existente entre estas. Dessa forma as macrófitas aquáticas podem indicar os impactos resultantes das mudanças hidrológicas nesse sistema de baías.
Relação da coagulação intravascular disseminada pela determinação do dímero-D com a COVID-19: uma revisão integrativa
Authors: Silva Mariana Lessi , Alves Igor de Oliveira Bezerra , Ribeiro Carolina Heitmann Mares Azevedo , Lo Prete Ana Cristina
Published: January 2022

A síndrome respiratória aguda grave causada pela COVID-19 foi recentemente relatada em Wuhan, capital da província chinesa de Hubei. A doença pode se manifestar de formas graves, em alguns desses casos, foram identificadas condições de hipercoagulabilidade seguido de alterações hematológicas. Este trabalho trata-se de uma revisão integrativa que avalia a relação da coagulação intravascular disseminada pela determinação do dímero-D com a COVID-19 e correlaciona esse marcador como um possível prognóstico da doença. Durante o estudo foi possível evidenciar que o aumento do dímero-D pode estar associado com uma maior gravidade da COVID-19 e/ou mortalidade, observada pelo aumento da ocorrência de CID, incluindo estudos em pacientes que evoluíram para quadros trombóticos, como TVP, TEV e embolia pulmonar. Além disso, tal associação em outras condições que aumentam a coagulação, como no caso de pacientes diabéticos tipo 2 e em pacientes que fizeram uso de ECMO.
Antagonism of different species of Lactobacillus spp. against phytobacteria
Authors: Tavares Rodolfo Sodré , Silva Paulo Alex Neves da , Machado Ludmila Batista , Nascimento Abadia dos Reis , Carneiro Lilian Carla , Vieira José Daniel Gonçalves
Published: January 2022

O tomateiro (Solanum lycopersicum L.) é uma das hortaliças mais importantes e mais cultivadas do mundo, possuindo um mercado de produtos derivados com alto apelo comercial. A inoculação de bactérias probióticas pode atuar na prevenção de doenças como, mancha bacteriana, murcha bacteriana, podridão mole, entre outras, além de diminuir a utilização de pesticidas e antibióticos, ajudando a mitigar o impacto à saúde humana e ambiental. Parte das amostras utilizadas para o isolamento de BAL foram coletadas a partir de folhas de tomateiros sadios na Escola de Agronomia (EA) da Universidade Federal de Goiás (UFG) e outra parte foi obtida de cultura starter a partir do mercado local. Dois métodos de antagonismo foram utilizados, o teste de difusão em meio líquido e o teste em meio sólido. Das 13 cepas testadas neste estudo, 10 apresentaram atividade contra diferentes fitobactérias, o teste de atividade antagônica em meio líquido mostrou-se melhor em comparação ao meio sólido, também foi encontrada ação antimicrobiana de amplo espectro e um halo de inibição de até 22 mm de diâmetro proveniente de uma cepa obtida a partir de cultura starter. Desta forma este trabalho demonstra a atividade antimicrobiana de cepas de BAL testadas in vitro contra diferentes fitobactérias.
Deficiência e COVID-19: “fazer viver e deixar morrer”?
Authors: Amorim Annibal Coelho
Published: January 2022

O ensaio estabelece correlações históricas entre medidas de engenharia social e eugenia, afetando o acesso aos cuidados de saúde de pessoas com deficiência durante a Pandemia no Brasil. Circunstâncias históricas remontam “ideais” propostos pelas Ligas de Eugenia, afetam a equidade em saúde de pessoas com deficiência durante essa crise sanitária. Examinam-se aspectos éticos relacionados na relação Covid-19 e deficiência diante da justificativa da escassez de recursos na Pandemia. Expostos entre “fazer viver, deixar morrer”, busca-se compreender impactos da pandemia nos territórios existenciais de pessoas com deficiência. Reflete-se acerca das “orientações” e “avaliações clínicas” deixam-se atravessar historicamente pela governamentalidade das práticas discursivas, afetando corpos dos sujeitos e o “corpo da sociedade”. A lógica economicista perpassa recomendações do “saber médico” corponormativando corpos que serão priorizados, em detrimento dos segmentos populacionais expostos à doença. Esse biodeterminismo aplicado à triagem de vítimas de Covid-19, abordado no trabalho de Milićević, explicita o uso da deficiência como fator de negação ao tratamento. Reinstitui-se a antinomia “normal”/“anormal” na tentativa de neutralizar a necropolítica no enfrentamento da Covid-19. O ensaio refere-se à Foucault dispondo a biopolítica do aparato médico para lidar com a população como problema científico e político. Para considerar o biodeterminismo que suprime o direito dos sujeitos, recorre-se à bioética pós-moderna de Engelhardt, examinando a atenção emergencial de pessoas com deficiência. O manuscrito trilha caminho bioético debate a equidade em saúde e eficiência na alocação de recursos. Finalmente, reflete-se sobre formas de contribuição da sociedade no mundo pós-pandêmico, privilegiando ético-esteticamente territórios existenciais das pessoas com deficiência.
Diferenças regionais de café da manhã em uma rede hoteleira no Brasil
Authors: Lima Gisele Estevão de , Silva Joásia Xavier da , Veloso Rodrigo Rossetti , Shinohara Neide Kazue Sakugawa
Published: January 2022

Não existe relação mais intima do que a do homem com o ato da alimentação. O que se come, como se come e onde se come, definem qual a cultura alimentar que se está inserido. A intrínseca relação entre o turismo e a gastronomia sempre ocorreu, porém pouco percebido ou estudado em trabalhos acadêmicos. Este levantamento teve como objetivo comparar as preparações culinárias oferecidas no café da manhã de uma rede hoteleira no Brasil e identificar diferenças da cozinha regional, com o intuito de garimpar evidências de que existem diferenças regionais no Brasil e que estas diferenças foram marcados inicialmente pelas culturas indígena, africana e portuguesa e mais recente pelos estrangeiros de diferentes regiões da Europa, ocorrendo a hibridização com nossos valores culinários, contribuindo para a regionalização do café da manhã. Esse fato peculiar de consumo demonstra que o desjejum matinal nos hotéis é um potencial inexplorado pelo trade hoteleiro nacional.
Efeitos do distanciamento social no consumo de bebidas: Uma pesquisa online com estudantes do interior do país
Authors: Freire Leonel Francisco de Oliveira , Leal Danielle Christina Lino , Mendes Jean Michel Regis , Regis Matheus da Silva , Lima João Lindemberg Bandeira , Silva Marielen Ghedin da , Monteiro Maria das Dores de Holanda , Maia Raimunda Gerlane Lima , Lima Francisca Darlânia Nobre , Rodrigues Perla Silva , Leal Rayza Maria Silva , Lima Isabela Pinheiro Cavalcanti
Published: January 2022

O ritmo acelerado da propagação do coronavírus levou ao governo de diversos países adotarem medidas de distanciamento social. Essa estratégia gera alterações emocionais que modificam o padrão de consumo, levando a ingestão excessiva de alimentos e bebidas com baixa qualidade nutricional, esse padrão parece ser intensificado entre estudantes. Considerando a vulnerabilidade deste público, este estudo tem como objetivo investigar e avaliar os impactos da pandemia no consumo de bebidas entre estudantes do ensino técnico e superior da rede federal de ensino. Metodologia: Os participantes da pesquisa responderam um questionário online autoaplicável contendo perguntas referentes ao consumo de bebidas no período anterior e durante a pandemia. Participaram do estudo 106 estudantes. Os dados foram analisados através da aplicação do teste qui-quadrado. Resultados: Os achados revelaram uma redução no consumo de bebidas alcoólicas, suco artificial e refrigerantes, em contraste houve uma elevação no consumo de sucos de fruta. Conclusão: Foi identificado uma melhorias no consumo de bebidas durante o período de distanciamento social entre os estudantes. No entanto, o aumento do consumo de bebidas prejudiciais à saúde, como o suco artificial, refrigerantes e bebidas alcóolicas, entre indivíduos que já apresentavam uma frequência de consumo elevada no período anterior a pandemia, podem revelar o cenário de vulnerabilidade vivido por estudantes no Brasil.
PENERAPAN TEORI CONNECTIONISM DALAM PEMBELAJARAN SUSUN HURUF SISWA MI DARUSSALAM GRESIK
Authors: Latifah Umi
Published: January 2022

Abstract: This research is motivated by children becoming the spirit of learning in various creative ways given by teachers or parents to children. Many ways and theories in learning exist to increase the spirit of children in the learning process, one of which is the theory of connectionism. Because it takes stimulus to train the development of the child in order to produce a response that is in accordance with the stimulus provided by practicing and appreciating the child's results. This article limits the problem to the application of connectionism theory with the law contained in the theory, namely the law of readiness, the law of practice, and the law of consequence. This study uses a qualitative approach. The design of this research is descriptive. This research data was obtained by conducting observations of learning activities of MI Darussalam Gresik students. The population of this study is junior high school students. The sample of this study is a grade 1 student of MI Darussalam Gresik. The data collection techniques used are descriptive. Based on the observations of learning obtained, 1)the law of readiness of STUDENTS MI Darussalam Gresik, 2)the law of training students MI Darussalam Gresik, and 3) the law due to students MI Darussalam GresikKeywords: learning, connectionism, lettering
Etnobotani Kopi di Desa Bambang Kecamatan Wajak Kabupaten Malang
Authors: Jauhari Nasrul , Hakim Luchman , Zayadi Hasan
Published: January 2022

This study aims to determine the types and characterization of coffee in Bambang Village and the pattern of cultivation and utilization of coffee in Bambang Village, Malang Regency. The method used in this study is observation and semi-structured interviews. Qualitative data analysis is presented in descriptive form. There are three types of coffee that are cultivated in Bambang Village, namely Coffea canephora, Coffea liberica and Coffea arabica. There are three constituent layers in coffee agroforestry, the top layer functions as a canopy consisting of Kaliandra, Jackfruit, Waru, Avocado, Lamtoro, Petai, Coconut. The middle layer consists of coffee, papaya and banana and the lower layer consists of taro, ginger and tubers. The complexity of making up coffee agroforestry is used as animal feed, firewood reserves, food sources, nutritional sources and building wood materials and the form of coffee utilization as a drink is often used as a daily dish, guest treats, arts, celebrations and traditional rituals.Keywords: Ethnobotany, Types of Coffee, Coffee AgroforestryABSTRAKPenelitian ini bertujuan untuk mengetahui jenis karakteristik kopi lokal dan pola budidaya serta pemanfaatan kopi yang ada di Desa Bambang Kabupaten Malang. Metode yang digunakan dalam penelitian ini adalah observasi dan wawancara semi terstruktur. Analisis data kualitatif disajikan dalam bentuk deskriptif. Terdapat tiga jenis kopi yang dibudidayakan di Desa Bambang yaitu jenis Coffea canephora, Coffea liberica dan Coffea arabica. Ada tiga lapisan penyusun di dalam agroforestri kopi Desa Bambang, lapisan atas berfungsi sebagai kanopi terdiri dari Kaliandra, Nangka, Waru, Alpukat, Lamtoro, Petai, Kelapa. Lapisan tengah terdiri dari Kopi, Pepaya dan Pisang dan lapisan bawah terdiri dari Talas, Jahe dan Umbi-umbian. Kompleksitas penyusun agroforestri kopi dimanfaatkan sebagai pakan ternak, cadangan kayu bakar, sumber makanan, sumber nutrisi dan bahan kayu bangunan dan bentuk pemanfaatan kopi sebagai minuman sering digunakan sebagai  sajian harian, suguhan tamu, kesenian, selamatan dan ritual adat.Kata kunci : Etnobotani, Jenis-Jenis Kopi, Agroforestri Kopi
Pemetaan Potensi Ekowisata di Wilayah Kecamatan Poncokusumo, Kabupaten Malang
Authors: Musytawan Baihaqi , Hakim Luchman , Zayadi Hasan
Published: January 2022

Ecotourism according to The International Ecotourism Society (TIES), is a responsible journey into natural areas that preserves the environment, maintains the welfare of local communities, and involves interpretation and education that includes management staff and visiting guests. This research is located in Poncokusumo District, Malang Regency. The data collection method uses field observation techniques assisted by GPS to determine the coordinates of the points. The interview method was used to find out more detailed information about the suitability of ecotourism. The data obtained were processed using spatial analysis techniques using the QGIS 10.3 application. The results of the spatial analysis obtained 9 ecotourism locations spread over 4 villages namely Wringinanom, Gubugklakah, Poncokusumo and Ngadas. The next stage is to find out the suitability of tourism activities in the context of ecotourism with field observations and interviews aimed at tourism managers. The data obtained that ecotourism in Poncokusumo District has not all applied the 3 principles of ecotourism according to the 2015 TIES Definition, especially on the principle of interpretation in River Tubing Ledok Amprong, Coban Bidadari and Gunungsari Sunset.Keywords: Ecotourism, Mapping, Poncokusumo, Suitability.ABSTRAKEkowisata menurut The International Ecotourism Society (TIES), sebuah perjalanan yang bertanggung jawab ke dalam daerah atau area alami (natural areas) yang melestarikan lingkungan, mempertahankan kesejahteraan masyarakat setempat, serta melibatkan interpretasi dan pendidikan yang mencakup staff pengelola dan tamu yang berkunjung. Penelitian ini bertempat di Kecamatan Poncokusumo Kabupaten Malang. Metode pengambilan data menggunakan teknik observasi lapangan yang dibantu dengan GPS untuk menentukan titik koordinat. Metode wawancara digunakan untuk mengetahui informasi lebih detail tentang kesesuaian ekowisata. Data yang diperoleh diolah menggunakan teknik analisis spasial menggunakan aplikasi QGIS 10.3. Hasil analisis spasial diperoleh 9 lokasi ekowisata yang tersebar pada 4 desa yaitu Wringinanom, Gubugklakah, Poncokusumo dan Ngadas. Tahapan selanjutnya yaitu mengetahui kesesuaian kegiatan wisata dalam konteks ekowisata dengan teknik observasi lapang dan wawancara yang ditujukan kepada pengelola wisata. Data yang diperoleh bahwa ekowisata di Kecamatan Poncokusumo belum semua menerapkan 3 prinsip ekowisata menurut Definisi TIES 2015 terutama pada prinsip interpretasi pada ekowista River Tubing Ledok Amprong, Coban Bidadari dan Gunungsari Sunset.Kata kunci : Ekowisata, Kesesuaian, Pemetaan, Poncokusumo.
URGENSI PEMAHAMAN JENIS KELAMIN DAN GENDER PADA ANAK USIA DINI
Authors: Jannah Shofiatul , Bramastia Lutfia Sefta
Published: January 2022

AbstrakAnak usia dini adalah yang berusia 0-8 tahun, anak usia dini usia 4-6 tahun mendapatkan pendidikan formal yang disebut dengan pendidikan anak usia dini di Taman Kanak-Kanak/Raudhatul Athfal, pendidikan ini memiliki fungsi untuk memberi stimulus pada anak usia dini agar aspek-aspek perkembangan dan potensi dasar yang dimiliki oleh anak berkembang hingga dapat menjadi fundamental awal anak agar dapat melanjutkan pendidikan selanjutnya. Pendidik berperan penting dalam edukasi pendidikan tentang gender dan jenis kelamin pada anak usia dini dengan menyesuaikan karakteristik anak usia dini. Penelitian ini bertujuan untuk mengetahui upaya pendidik dalam edukasi pendidikan tentang jenis kelamin dan gender pada anak usia dini. Metode penelitian yang digunakan adalah penelitian kualitatif. Pendidik memiliki beberapa upaya untuk memberi edukasi pendidikan tentang gender dan jenis kelamin pada anak usia dini. Kata Kunci: Anak Usia Dini, Pendidikan Anak Usia Dini, Pendidik, Edukasi jenis kelamin dan gender.
The Effect of Tapping on Functional Changes in Spinal Mobility and Respiratory System in Adolescents with Idiopatic Scolosis: Pilot Study
Authors: Čeponkienė Ilona , Aleknavičiūtė-Ablonskė Vaida
Published: January 2022

Background. Scoliosis affects spinal mobility and the respiratory system. The Schroth method is an effective tool for the treatment of scoliosis. However, there is insufficient evidence for the efficiency of kinesio taping with the Schroth method to help manage the condition of spinal mobility and respiratory system changes for adolescents with idiopathic scoliosis.

The aim. To evaluate the efficacy of the Schroth method and the Schroth method in combination with kinesio taping for spinal mobility and functional changes in the respiratory system in adolescents with idiopathic scoliosis.

The methods. The study included 8 adolescent volunteers diagnosed with idiopathic scoliosis. The adolescents were divided into two groups. The Schroth method was used for the first group and the Schroth method with kinesiology taping for the second group. The study lasted 2 months, and both groups underwent 2 interventions per week. Both before and after the interventions, participants were assessed for trunk functional stability (Mathias test), lumbar and thoracic spine mobility (Schober and Otto tests), vital lung capacity (VC), and forced expiratory capacity in 1 s (FEV1).

The results. In the analysed results of the interventions, it was found that the Mathias test, the Schober and Otto test, the VC and the FEV1 were improved in both groups. Comparing the results between the groups, it was established that the spinal mobility was better (p < 0,05) in the second group. However, lumbar and thoracic spinal mobility, VC, FEV1 were better (p<0,05) in the first group.

The conclusion. The Schroth method with and without kinesiological taping increased trunk stability, spinal cord mobility, and VC and FEV1. The Schroth method with kinesio taping is more effective for trunk functional stability, however only the Schroth method is more effective with mobility of the lumbar and thoracic spine part as well as for VC and FEV1.

Keywords: spinal cord mobility, trunk functional mobility, vital capacity.
Serving as a Graduate Teaching Assistant: Tips and Strategies
Authors: Nemerever Zoe , Rubalcava Bianca
Published: January 2022

This chapter outlines the roles and expectations of teaching assistants and discusses resources and strategies for a successful and rewarding experience. This manuscript is part of Strategies for Navigating Graduate School and Beyond, a forthcoming volume for those interested in pursuing graduate education in political science (Fall 2022 publication).
ОТНОШЕНИЕ К БОГАТСТВУ В РУССКОЙ ЦЕРКОВНОЙ ТРАДИЦИИ (X-XVII ВВ.)
Authors: Кириченко Олег Викторович
Published: January 2022

Статья посвящена вопросу конвертации богатства — духовному преобразованию его за счет полной или частичной передачи его на нужды Церкви или нуждающихся членов общества. Автор показывает, что данный процесс носил системный характер и имел огромное влияние на особенности развития страны в целом. Данная тема продолжена в публикациях автора в 15, 17, 18 и 19 номерах журнала.
Памяти Марины Михайловны Громыко
Authors: Кириченко Олег Викторович
Published: January 2022

В статье определены теоретические подходы М. М. Громыко, связанные с ее православным мировоззрением.
A New Two-Parameter Estimator for Beta Regression Model: Method, Simulation, and Application
Authors: Abonazel Mohamed R. , Algamal Zakariya Yahya , Awwad Fuad A. , Taha Ibrahim M.
Published: January 2022

The beta regression is a widely known statistical model when the response (or the dependent) variable has the form of fractions or percentages. In most of the situations in beta regression, the explanatory variables are related to each other which is commonly known as the multicollinearity problem. It is well-known that the multicollinearity problem affects severely the variance of maximum likelihood (ML) estimates. In this article, we developed a new biased estimator (called a two-parameter estimator) for the beta regression model to handle this problem and decrease the variance of the estimation. The properties of the proposed estimator are derived. Furthermore, the performance of the proposed estimator is compared with the ML estimator and other common biased (ridge, Liu, and Liu-type) estimators depending on the mean squared error criterion by making a Monte Carlo simulation study and through two real data applications. The results of the simulation and applications indicated that the proposed estimator outperformed ML, ridge, Liu, and Liu-type estimators.
Shifting Baselines May Undermine Shoreline Management Efforts in the United States
Authors: Correll-Brown Riordan , Wellman Emory H. , Eulie Devon O. , Scyphers Steven B. , Smith Carter S. , Polk Mariko A. , Gittman Rachel K.
Published: January 2022

Rising sea levels, extreme weather events, and unsustainable coastal zone development pose serious threats to growing coastal communities. Human actions, such as shoreline development and hardening in at-risk areas, can damage nearshore ecosystems and exacerbate existing risks to coastal populations. A comprehensive understanding of shoreline changes in response to development, storm events, and sea-level rise is needed to effectively mitigate coastal hazards and promote adaptive and resilient coastlines. To determine whether human modification of shorelines can be accurately quantified and assessed over time, we evaluated past and present shoreline mapping and classification efforts in the United States. We coupled a review of available US shoreline data with a survey of coastal planners and managers involved with US state shoreline mapping programs. Using these data, we estimated the current extent of shoreline modification along the Atlantic, Pacific, and Gulf US coasts. However, we found that quantifying shoreline modifications over time nationally—or even within a single state—is currently infeasible due to changes in shoreline resolution associated with advances in shoreline mapping methodologies and a lack of regularly updated shoreline maps. State-level analysis from surveys revealed that 20 US coastal states have undertaken shoreline mapping projects, with sixteen tracking shoreline type and/or condition. However, of the 36 shoreline maps and databases identified, only half (18) were updated regularly or had planned updates. Lacking shoreline change data, coastal communities risk accepting increasingly degraded coastal zones and making poor management decisions based on shifted baselines. Thus, we recommend increasing the scale and funding for several ongoing innovative shoreline mapping efforts. These efforts are particularly focused on improving and standardizing shoreline mapping techniques, as well as establishing accurate baselines for shoreline conditions in the United States. Without accurate baselines and regular, consistent updates to shoreline data, managers cannot manage shorelines in a way that effectively mitigates coastal hazards while also promoting socio-ecological resilience in a changing climate.
Reduction of Genetic Variation When Far From the Niche Centroid: Prediction for Mangrove Species
Authors: Ochoa-Zavala Maried , Osorio-Olvera Luis , Cerón-Souza Ivania , Rivera-Ocasio Elsie , Jiménez-Lobato Vania , Núñez-Farfán Juan
Published: January 2022

The niche-centroid hypothesis states that populations that are distributed near the centroid of the species' ecological niche will have higher fitness-related attributes, such as population abundance and genetic diversity than populations near the edges of the niche. Empirical evidence based on abundance and, more recently, genetic diversity data support this hypothesis. However, there are few studies that test this hypothesis in coastal species, such as mangroves. Here, we focused on the black mangrove Avicennia germinans. We combined ecological, heterozygosity, and allelic richness information from 1,419 individuals distributed in 40 populations with three main goals: (1) test the relationship between distance to the niche centroid and genetic diversity, (2) determine the set of environmental variables that best explain heterozygosity and allelic richness, and (3) predict the spatial variation in genetic diversity throughout most of the species' natural geographic range. We found a strong correlation between the distance to the niche centroid and both observed heterozygosity (Ho; ρ2 = 0.67 P < 0.05) and expected heterozygosity (He; ρ2 = 0.65, P < 0.05). The niche variables that best explained geographic variation in genetic diversity were soil type and precipitation seasonality. This suggests that these environmental variables influence mangrove growth and establishment, indirectly impacting standing genetic variation. We also predicted the spatial heterozygosity of A. germinans across its natural geographic range in the Americas using regression model coefficients. They showed significant power in predicting the observed data (R2 = 0.65 for Ho; R2 = 0.60 for He), even when we considered independent data sets (R2= 0.28 for Ho; R2 = 0.25 for He). Using this approach, several genetic diversity estimates can be implemented and may take advantage of population genomics to improve genetic diversity predictions. We conclude that the level of genetic diversity in A. germinans is in agreement with expectations of the niche-centroid hypothesis, namely that the highest heterozygosity and allelic richness (the basic genetic units for adaptation) are higher at locations of high environmental suitability. This shows that this approach is a potentially powerful tool in the conservation and management of this species, including for modelling changes in the face of climate change.
Representation of Jews and Anti-Jewish Bias in 19th Century French Public Discourse: Distant and Close Reading
Authors: Levis Sullam Simon , Minello Giorgia , Tripodi Rocco , Warglien Massimo
Published: January 2022

We explore through the lens of distant reading the evolution of discourse on Jews in France during the XIX century. We analyze a large textual corpus including heterogeneous sources—literary works, periodicals, songs, essays, historical narratives—to trace how Jews are associated to different semantic domains, and how such associations shift over time. Our analysis deals with three key aspects of such changes: the overall transformation of embedding spaces, the trajectories of word associations, and the comparative projection of different religious groups over different, historically relevant semantic dimensions or streams of discourse. This allows to show changes in the association between words and semantic domains (referring e.g. to economic and moral behaviors), the evolution of stereotypes, and the dynamics of bias over a long time span characterized by major historical transformations. We suggest that the analysis of large textual corpora can be fruitfully used in a dialogue with more traditional close reading approaches—by pointing to opportunities of in-depth analyses that mobilize more qualitative approaches and a detailed inspection of the sources that distant reading inevitably tends to aggregate. We offer a short example of such a dialogue between different approaches in our discussion of the Second Empire transformations, where we mobilize the historian’s tools to start disentangling the complex interactions between changes in French society, the nature of sources, and representations of Jews. While our example is limited in scope, we foresee large potential payoffs in the cooperative interaction between distant and close reading.
Seismic Imaging of Lithospheric Structure Beneath Central-East Java Region, Indonesia: Relation to Recent Earthquakes
Authors: Muttaqy Faiz , Nugraha Andri Dian , Mori James , Puspito Nanang T. , Supendi Pepen , Rohadi Supriyanto
Published: January 2022

The Central and East Java region, which is part of the Sunda Arc, has an important role in producing destructive earthquakes and volcanic complexes in Indonesia as a result of the convergence between the Indo-Australian plate that subducts under the Eurasian plate. In this study, the 3-D seismic velocity structure (Vp, Vs, and Vp/Vs) of the crust and upper mantle was determined to reveal the presence of the subducted slab, volcanic sources, and seismogenic features in the Central and East Java region. We have manually re-picked P- and S-arrivals of 1,488 events from January 2009 to September 2017 recorded at 27 stations of the BMKG network. An iterative damped least-squares inversion method was applied to simultaneously calculate both hypocenter relocations and velocity structure beneath this high-risk region to a depth of 200 km. We then compare the tomographic results and seismicity to interpret structural features in the seismic zones. The subducted slab is dipping toward the north, imaged by the high-velocity regions with low Vp/Vs at depths of about 50–100 km. Low-velocity anomalies with high Vp/Vs above the slab at a depth of ∼100 km, imply the possible location of partial melting from slab dehydration. Fluids and melts are ascending to feed the volcanoes i. e., Merapi-Merbabu, Wilis, Pandan, Semeru, Bromo, and Ijen that also have similar low-velocity anomalies at 10–30 km depths, suggesting the presence of the sedimentary basin or magma reservoir. We also have redetermined the hypocenter location of the 2021 (Mw 6.1) Malang earthquake at 8.94oS, 112.45oE, with a depth of 59.7 km. The location error in the x, y, and z directions are 3.08, 6.39, and 11.91 km, respectively. This intraslab event with a thrusting mechanism is located in the high-velocity region and close to the intermediate-depth seismic clusters, which indicates the geometry of the oceanic slab. In the region of 1994 (Mw 7.8) Banyuwangi earthquake, we found a low-velocity anomaly at ∼ 50 km depth that might be associated with the presence of subducting seamount that is more hydrated than the surrounding slab. The slip over this subducting seamount caused the tsunamigenic earthquake.
Hyperprolactinemia and Hypopituitarism in Acromegaly and Effect of Pituitary Surgery: Long-Term Follow-up on 529 Patients
Authors: Guo Xiaopeng , Zhang Ruopeng , Zhang Duoxing , Wang Zihao , Gao Lu , Yao Yong , Deng Kan , Bao Xinjie , Feng Ming , Xu Zhiqin , Yang Yi , Lian Wei , Wang Renzhi , Ma Wenbin , Xing Bing
Published: January 2022

Purpose

Studies on hyperprolactinemia and hypopituitarism in acromegaly are limited. We aimed to analyze the preoperative status, postoperative alterations, and correlated factors of hyperprolactinemia and hypopituitarism in acromegaly patients.

Methods

This is a single-center cohort study with long-term follow-up. We prospectively enrolled 529 acromegaly patients. Hyperprolactinemia and hypopituitarism were evaluated by testing hypothalamus-pituitary-end organ (HPEO) axes hormones before and after surgery.

Results

Hyperprolactinemia (39.1%) and hypopituitarism (34.8%) were common in acromegaly. The incidences of axis-specific hypopituitarism varied (hypogonadism, 29.7%; hypothyroidism, 5.9%; adrenal insufficiency, 5.1%), and multiple HPEO axes dysfunction was diagnosed in 5.3% of patients. Patients with preoperative hyperprolactinemia [hazard ratio (HR)=1.39 (1.08-1.79); p=0.012], hypogonadism [HR=1.32 (1.01-1.73); p=0.047], and hypothyroidism [HR=3.49 (1.90-6.44); p<0.001] had higher recurrence rates than those without. Age, sex, body mass index, tumor size, invasiveness, prolactin staining, ki-67 index, and GH/IGF-1 levels were significantly correlated with preoperative hypopituitarism and hyperprolactinemia. At median 34-month follow-up after surgery, hyperprolactinemia in 95% and axis-specific hypopituitarism in 54%-71% of patients recovered, whereas new-onset hypopituitarism (hypogonadism, 6.2%; hypothyroidism, 4.0%; adrenal insufficiency, 3.2%) was also diagnosed. A shorter tumor diameter was associated with the normalization of preoperative hyperprolactinemia after surgery. Cavernous sinus non-invasion, a shorter tumor diameter, cure at follow-up, and a lower GH nadir level were associated with the improvement of preoperative hypopituitarism after surgery. A larger tumor diameter was associated with the newly developed hypopituitarism after surgery.

Conclusion

Hyperprolactinemia and hypopituitarism are common among acromegaly patients and predict worse surgical outcomes. After surgery, improvement and worsening of HPEO axes function co-exist. Correlated factors are identified for clinical management.
Impact of Green Construction Procurement on Achieving Sustainable Economic Growth Influencing Green Logistic Services Management and Innovation Practices
Authors: Sandra Marcelline Tsimisaraka Raymondo , Chengang Ye , Ralison Ny Avotra Andrianarivo Andriandafiarisoa , Hussain Zahid , Zonia Josoa Eric , Nawaz Ahsan
Published: January 2022

Green construction procurement is a part of the sustainable development goals (SDGs) that influence economic growth on a strategic level. Adopting green technologies and practices has no longer been an option but a well-worth route for gaining a competitive advantage in the construction sector. The emergent concepts of green procurement and sustainability have raised the need to measure the financial performances in supply chain practices. Green procurement is now gaining importance in the construction industry and supply chain practices for a safer tomorrow. The study aimed to investigate the impact of construction procurement on green logistic services, innovation practices, and their subsequent role in gaining sustainable economic development goals. The population frame for this study was the project teams (engineers and project managers) of construction companies in China. The sampling design followed was convenient random sampling. The study was conducted using self-administered questionnaire surveys to avoid any respondent biases and/or errors. The study's findings show that construction procurement is partially associated with green logistic services management, which thoroughly determines the sustainable economic development goals. Furthermore, construction procurement is found to have a significant impact on green innovation practices that partially predict the SDGs, and the mediation of green logistic services and innovation practices are partially mediated to the construction procurement and sustainable goals. In the future, the study results will help the construction practitioners, contractors, bidders, and engineering community to shape their relationships in a greener way up or down the stream of their supply chains. Additionally, the implication of green procurement and logistic services offers many challenges in the long run for attaining SDGs; however, in the short run, it gives operational efficiency and less hazardous environmental emissions.
Case Analysis of Turbulence From High-Resolution Sounding Data in Northwest China
Authors: Qin Zilin , Sheng Zheng , He Yang , Feng Yutao
Published: January 2022

This study calculated the Thorpe scale, thickness of turbulent layer, turbulent kinetic energy dissipation rate, and turbulent diffusion coefficient based on the Thorpe method using a set of near-space high-resolution radiosonde data in northwest China, and a case study was conducted to analyze the large-scale turbulent layer in the middle stratosphere. The results showed that the most turbulent layers exist near from the middle and upper troposphere to the tropopause region, accounting for 44.0% of the total turbulence, and the largest Thorpe scale and thickness of turbulent layer also appear in this altitude range. In addition, affected by the large-scale turbulence near the tropopause, the calculated turbulent energy dissipation rate and diffusion coefficient also have maximum values at this altitude, which are 0.003 m2s−3 and 6.94 m2s−1, respectively. By analyzing the meteorological elements, it is found that there is an obvious correlation between precipitation and large-scale turbulence in the stratosphere. When the precipitation occurs, the corresponding two sets of radiosondes detected larger-scale turbulence layers in the middle stratosphere.
Case Report: Endocapillary Glomerulopathy Associated With Large Granular T Lymphocyte Leukemia
Authors: Zhao Tao , Hu Nan , Yu Xiaojuan , Su Tao
Published: January 2022

Large granular T lymphocyte leukemia (T-LGLL) is a rare indolent lymphocyte leukemia. The clonal proliferation of T cells, which is related to STAT3 gene mutation and abnormal Fas-mediated apoptosis pathway after cell activation, plays a major role in disease progression. Some studies have found that the exogenous and continuous stimulation of endogenous antigens, such as virus infection, is related to the pathogenesis of T-LGLL. The renal pathological manifestations of T-LGLL have rarely been described. In this study, we report a case of T-LGLL with kidney involvement as proteinuria, acute kidney injury, with the appearance of circulating T-LGL infiltrating intra-glomerular capillaries, and endocapillary glomerulopathy. We also summarize reported cases of renal injury associated with LGLL.
A Novel Immunobiotics Bacteroides dorei Ameliorates Influenza Virus Infection in Mice
Authors: Song Liqiong , Huang Yuanming , Liu Guoxing , Li Xianping , Xiao Yuchun , Liu Chang , Zhang Yue , Li Jintong , Xu Jianguo , Lu Shan , Ren Zhihong
Published: January 2022

Objective

Probiotics can modulate immune responses to resist influenza infection. This study aims to evaluate the anti-viral efficacy of B. dorei.

Methods

C57BL/6J mice were infected with influenza virus together with treatment of PBS vehicle, B. dorei, or oseltamivir respectively. Anti-influenza potency of B. dorei and the underlying mechanism were determined by measuring survival rate, lung viral load and pathology, gene expression and production of cytokines and chemokines, and analysis of gut microbiota.

Results

Administration of B. dorei increased (by 30%) the survival of influenza-infected mice, and improved their weight loss, lung pathology, lung index, and colon length compared to the vehicle control group. B. dorei treatment reduced (by 61%) the viral load of lung tissue and increased expression of type 1 interferon more rapidly at day 3 postinfection. At day 7 postinfection, B. dorei-treated mice showed lower local (lung) and systemic (serum) levels of interferon and several proinflammatory cytokines or chemokines (IL-1β, IL-6, TNF-α, IL-10, MCP-1 and IP-10) with a efficacy comparable to oseltamivi treatment. B. dorei treatment also altered gut microbiota as indicated by increased levels of Bacteroides, Prevotella, and Lactobacillus and decreased levels of Escherichia, Shigella, and Parabacteroides.

Conclusion

B. dorei has anti-influenza effect. Its working mechanisms involve promoting earlier interferon expression and down-regulating both local and systemic inflammatory response. B. dorei changes the composition of gut microbiota, which may also contribute to its beneficial effects.
Peptide Biomarkers for the Diagnosis of Dengue Infection
Authors: Falconi-Agapito Francesca , Kerkhof Karen , Merino Xiomara , Bakokimi Diana , Torres Fiorella , Van Esbroeck Marjan , Talledo Michael , Ariën Kevin K.
Published: January 2022

In a world with an increasing population at risk of exposure to arthropod-borne flaviviruses, access to timely and accurate diagnostic tests would impact profoundly on the management of cases. Twenty peptides previously identified using a flavivirus proteome-wide microarray were evaluated to determine their discriminatory potential to detect dengue virus (DENV) infection. This included nine peptides recognized by IgM antibodies (PM peptides) and 11 peptides recognized by IgG antibodies (PG peptides). A bead-based multiplex peptide immunoassay (MPIA) using the Luminex technology was set-up to determine Ab binding levels to each of these peptides in a panel of 323 carefully selected human serum samples. Sera are derived from individuals either infected with different viruses, namely, the four DENV serotypes, Zika virus (ZIKV), yellow fever virus (YFV), chikungunya virus (CHIKV), West Nile virus (WNV) and Human immunodeficiency virus (HIV), or receiving vaccination against YFV, tick-borne encephalitis (TBEV), and Japanese encephalitis virus (JEV). Additionally, a set of healthy controls were included. We targeted a minimum specificity of 80% for all the analysis. The PG-9 peptide had the best sensitivity (73%) when testing DENV sera from acute patients (A-DENV; <8 days since symptom onset). With sera from convalescent DENV patients (C-DENV; >10 days since symptom onset) the FPG-1 peptide was the best seromarker with a sensitivity of 86%. When combining all A-DENV and C-DENV samples, peptides PM-22 and FPG-1 had the best-diagnostic performance with a sensitivity of 60 and 61.1%, and areas under the curve (AUC) of 0.7865 and 0.8131, respectively. A Random forest (RF) algorithm was used to select the best combination of peptides to classify DENV infection at a targeted specificity >80%. The best RF model for PM peptides that included A-DENV and C-DENV samples, reached a sensitivity of 72.3%, while for PG peptides, the best RF models for A-DENV only, C-DENV only and A-DENV + C-DENV reached a sensitivity of 88.9%, 89.1%, and 88.3%, respectively. In conclusion, the combination of multiple peptides constitutes a founding set of seromarkers for the discrimination of DENV infected individuals from other flavivirus infections.
Modeling of Direct Economic Losses of Storm Surge Disasters Based on a Novel Hybrid Forecasting System
Authors: Guo Hongbo , Yin Kedong , Huang Chong
Published: January 2022

Modeling the direct economic losses of storm surge disasters can assess the disaster situation in a timely manner and improve the efficiency of post-disaster management in practice, which is acknowledged as one of the most significant issues in clean production. However, improving the forecasting accuracy of direct economic losses caused by storm surge disasters remains challenging, which is also a major concern in the field of disaster risk management. In particular, most of the previous studies have mainly focused on individual models, which ignored the significance of reduction and optimization. Therefore, a novel direct economic loss forecasting system for storm surge disasters is proposed in this study, which includes reduction, forecasting, and evaluation modules. In this system, a forecasting module based on an improved machine learning technique is proposed, which improves the generalization ability and robustness of the system. In addition, the key attributes and samples are selected by the proposed reduction module to further improve the forecasting performance from the two innovative perspectives. Moreover, an evaluation module is incorporated to comprehensively evaluate the superiority of the developed forecasting system. Data on the storm surge disasters from three typical provinces are utilized to conduct a case study, and the performance of the proposed forecasting system is analyzed and compared with eight comparison models. The experimental results show that the mean absolute percentage error (MAPE) predicted by the Extreme Learning Machine (ELM) model was 16.5293%, and the MAPE predicted by the proposed system was 1.0313%. Overall, the results show that the performance of the proposed forecasting system is superior compared to other models, and it is suitable for the forecasting of direct economic losses resulting from storm surge disasters.
Dynamic APACHE II Score to Predict the Outcome of Intensive Care Unit Patients
Authors: Tian Yao , Yao Yang , Zhou Jing , Diao Xin , Chen Hui , Cai Kaixia , Ma Xuan , Wang Shengyu
Published: January 2022

Objective

This study aims to evaluate the accuracy of the Acute Physiology and Chronic Health Evaluation (APACHE) II score on different days in predicting the mortality of critically ill patients to identify the best time point for the APACHE II score.

Methods

The demographic and clinical data are retrieved from the Medical Information Mart for Intensive Care (MIMIC)-IV dataset. APACHE II scores on days 1, 2, 3, 5, 7, 14, and 28 of hospitalization are calculated, and their performance is evaluated using the area under the receiver operating characteristic (AUROC) analysis. The cut-off for defining the high risk of mortality is determined using Youden's index. The APACHE II score on day 3 is the best time point to predict hospital mortality of ICU patients. The Hosmer-Lemeshow goodness-of-fit test is then applied to evaluate the calibration of the day 3 APACHE II score.

Results

We recruited 6,374 eligible subjects from the MIMIC-IV database. Day 3 is the optimal time point for obtaining the APACHE II score to predict the hospital mortality of patients. The best cut-off for day 3 APACHE II score is 17. When APACHE II score ≥17, the sensitivity for the non-survivors and survivors is 92.8 and 82.2%, respectively, and the positive predictive value (PPV) is 23.1%. When APACHE II socre <17, the specificity for non-survivors and survivors is 90.1 and 80.2%, respectively, and the negative predictive value (NPV) is 87.8%. When day-3 APACHE II is used to predict the hospital mortality, the AUROC is 0.743 (P <0.001). In the ≥17 group, the sensitivity of non-survivors and survivors is 92.2 and 81.3%, respectively, and the PPV is 30.3%. In the <17 group, the specificity of non-survivors and survivors is 100.0 and 80.2%, respectively, and the NPV is 81.6%. The Hosmer-Lemeshow test indicated day-3 APACHE II has a high predicting the hospital mortality (X2 = 6.198, P = 0.625, consistency = 79.4%). However, the day-1 APACHE II has a poor calibration in predicting the hospital mortality rate (X2 = 294.898, P <0.001).

Conclusion

Day-3 APACHE II score is an optimal biomarker to predict the outcomes of ICU patients; 17 is the best cut-off for defining patients at high risk of mortality.