bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Penanggulangan Stunting di Nagari Labuah Panjang Kecamatan X Koto Diatas Kabupaten Solok Berbasis Posyandu: Studi Kasus Posyandu Mawar Melati
Authors: Kabullah Muhammad Ichsan , Aromatica Desna , Kusdarini Kusdarini , Koeswara Hendri , Yulivestra Malse
Published: June 2023

Solok Regency is one of the regencies that occupy the highest prevalence of stunting in West Sumatra Province, with a total of 41.47% with details child's height of 15.77% concise and 25.70% short. The various negative impacts of stunting will be challenging to handle amid the current Covid-19 pandemic due to the increasing economic burden on families and poverty rates. It directly affects the increasing number of malnutrition children receive. A malnourished child gradually fails to achieve a standard and healthy height according to age. Stunting has an impact on reducing the IQ of children in Indonesia by 10 to 15 points. There needs to be a substantial effort to provide strategy in the context of stunting prevention so that the program of integrated community service post is directed measurably. These strategies are expected to generate a definite commitment from every policymaker to push down the stunting problem. The steps in this community engagement were problem identification, introducing innovation and best practices, and making an action plan. The recommended substantial efforts were massive media campaigns, increasing responsible personnel competence, and changing the Local Government Budget Planning pattern.
Optimasi Budidaya dan Pemasaran Maggot Black Soldier Fly di Kelompok Peternak Labung Raya untuk Bahan Pakan Sumber Protein
Authors: Ratni Eli , Montesqrit Montesqrit , Setyaka Virtuous
Published: June 2023

The main problem of livestock farming is still providing qualified feed at lower costs. Commercial feed prices are not suitable for traditional farming, thus increasing production costs more. The Labung Raya farmer's group understood that the provision of maggot larvae of Black Soldier Fly (BSF) could meet the protein needs of the livestock, such as poultry and catfish. The problems raised so far were that the growth of maggot produced was not maximized, such as few eggs, small larval body size, maggot coming out of the bucket, and not optimal fermentation of maggot feed. The activity began with a brainstorming event about the negative impact of the Covid-19 pandemic on the community. The implementation of the activities was continued with the method of counselling, training, and continuous mentoring. This community engagement was welcomed by the general community and the Labung Raya breeder group's partners. The practice of cultivating Maggot BSF is straightforward for anyone to do. The cultivation process only requires simple technology and low cost but requires breeding skills for optimal results. Maggot as a product is expected to be used as an alternative protein-rich animal feed ingredient in soaring prices for conventional feed, especially for poultry.
Pembimbingan dan Pendampingan Pendaftaran HKI Merek Dagang pada UMKM di Desa Kualu Kabupaten Kampar
Authors: Ardi Fira Nabilah , Mutamima Anisa , Fitrianingrum Tiara Indah
Published: June 2023

Mutiara Ayu is a Micro, Small, and Medium Enterprise (MSME) founded in November 2020 by a group of housewives in Mutiara Kualu 8 Housing Complex, Kualu Village, Tambang District, Kampar Regency. Mutiara Ayu produces Healthy Soybean Milk using natural ingredients without the addition of preservatives, artificial sweeteners, and synthetic flavors. In running their business, MSME Mutiara Ayu experienced various problems, such as the production process was not optimal, the product was not standardized and certified, and the trademark was not registered. The University of Riau Abdimas team was integrated with the Real Work Lecture (Kukerta) program in partnership with MSME Mutiara Ayu by assisting in solving the problems being faced by increased knowledge and skills. One of the activities carried out was guidance and assistance in registering trademarks. Through this activity, it was hoped that Mutiara Ayu could understand the procedures and register their trademarks at the Ministry of Law and Human Rights (Kemenkumham). With the official registration of trademarks at the Ministry of Law and Human Rights, Mutiara Ayu could obtain the power and legal protection for registered trademarks, could promote and market products in the broader market, increase competitiveness in the business, and prevent products from plagiarism.
Edukasi Peningkatan Pengetahuan Masyarakat dalam Menerapkan Konsep 3R, Pencegahan Penyakit Tidak Menular, Pintar dengan Obat dan PHBS di Nagari Paninggahan
Authors: Siswati Sri , Shalda Ghina Azaria , Vijay Seftiando Tehira Ago , Suhendri Devina Rahmadayanthi , R Natashya Aurellia , Jennifer Jennifer , Khisti Mawazinal , Najla Azarine Sidqi , Fauziah Gusrina
Published: June 2023

Environmental factors primarily influence the degree of public health. However, what is happening in today's society in improving the degree of health is even higher in health services. Many people receive curative treatment in health facilities but pay little attention to personal and environmental hygiene. The problems in Nagari Paninggahan are the need for more knowledge and awareness of the Paninggahan community in waste management, non-communicable diseases, rational use of drugs, and personal hygiene. This activity aims to increase public knowledge and awareness to improve the health status of the Paninggahan community. This activity was carried out using health promotion methods and practices and through leaflets. The results were that people could use used goods to make new, more valuable goods, understand that diseases such as hypertension must be appropriately handled with routine checks, know how to use the right medicines and practice proper hand washing to avoid various diseases. This activity hopes to increase public knowledge and awareness to avoid disease and improve the health status of the Paninggahan community.
Sosialisasi dan Pelatihan Pemeliharaan Unggas Lokal di Kelompok Wanita Tani Kejora Sawahlunto
Authors: Amizar Robi , Wizna Wizna , Mirzah Mirzah , Djulardi Ade
Published: June 2023

This activity aims to realize a growing livestock business in Kelompok Wanita Tani (KWT) Kejora in Sawahlunto that can generate profits to increase household incomes for KWT Kejora partner groups. The implementation of this activity was carried out in three stages; the first was the delivery of material and distributing questionnaires, the second stage was training and modeling, and the third stage was post-training assistance. The service activities in the form of socialization and training on local poultry farming at the KWT Kejora Sawahlunto have been carried out well. The result of this activity was that this activity was attended by 20 group members and accompanied by field officers from the Food Security, Agriculture, and Fisheries Service of Swahlunto City. Group members generally know about local poultry farming (village chicken) but do not know how to raise chickens properly and do not know the factors that affect the sustainability of the livestock business. Therefore, this group must continue to be accompanied so that the sustainability of the group's business can develop and increase the household income of group members.
Edukasi Gizi dan Pembinaan Kelompok Dasa Wisma dalam Pemanfaatan Pekarangan Berbasis Daun Kelor di Kecamatan Pauh Kamba, Padang Pariaman
Authors: Syahrial Syahrial , Helmizar Helmizar , Fitri Salma Nur
Published: June 2023

Nutritional status is an essential indicator of children's health status because it is a risk factor for morbidity and mortality. Good nutritional status in children will contribute to their health in recovering from illness. Malnutrition is a condition in children's weight for age (BB/U) that does not match their age. Moringa leaf (Moringa oleifera) is a functional food from the monogeneric Moringaceae family and contains several minerals. The purpose of this community service was to empower the Dasa Wisma group to utilise the community's yard by planting Moringa to improve the nutritional status of toddlers and reduce Stunting rates. This service was carried out from April to July 2022 at the Stunting locus, i.e. Pauh Kamba District, Padang Pariaman Regency. The activities included coaching the Dasa Wisma group regarding Stunting, how to overcome Stunting, processing Moringa leaves as a source of nutrition and family income, and evaluating Dasa Wisma group activities in processing Moringa leaves into food. The partnership program is expected to have sustained assistance from an expert to the community in the village.
Pemicuan Community Led Total Sanitation di Jorong Ronah Bengkek Kecamatan Kapur IX Kabupaten 50 Kota
Authors: Zulkarnaini Zulkarnaini , Gusmeri Elva
Published: June 2023

Community Led Total Sanitation (CLTS) is an approach to changing hygiene and sanitation behaviour through community empowerment with a triggering method that aims to change the behaviour of people who defecate anywhere. Environmental-based diseases, primarily related to water-borne diseases, still dominate the prevalence of diseases in Indonesia. Changing hygiene and sanitation behaviour through community empowerment is needed to improve the health status of the community as high as possible. Community service activities were conducted through interviews, triggering activities and community observations. The flow of triggering activities were introductions, conveying intentions and objectives, atmosphere building, identification of local languages, simple mapping, counting faeces, transect walk, water contamination paths, discussions, social contracts, and free defecation commitment. Participants who previously did not have latrine facilities became aware of and committed to constructing latrines independently. The village where this activity has been carried out will soon become an open defecation-free village. Become a promotor for monitoring and triggering activities for people to stop open defecation.
Physiological response of cocoa (Theobroma cacao L. ) genotypes to drought
Authors: Suchithra M. , Suma B. , Minimol J.S. , Mathew Deepu , Santhosh Kumar A.V.
Published: June 2023

Drought is one of the major environmental stresses affecting crop productivity worldwide. Climate change is expected to result in a rise in the number and intensity of drought events in the coming decades, so climate-resilient crops that can withstand this stress are in high demand. There are few genotypes in cocoa where it can tolerate water deficit conditions. The objective of the current investigation was to evaluate the effect of drought stress on the photosynthetic and physiological parameters of six cocoa genotypes (Theobroma cacao L.) with two irrigation regimes (100% field capacity and 40% field capacity) under greenhouse conditions at Cocoa Research Station, Kerala Agricultural University, Thrissur. The effect of water deficit conditions on gas exchange and physiological parameters such as relative water content, membrane stability index, chlorophyll stability index, and chlorophyll content were evaluated. Drought stress conditions resulted in reduced photosynthetic rate, relative water content, chlorophyll content, chlorophyll stability and membrane stability. All genotypes revealed significant differences for most parameters with two irrigation regimes. Among the cocoa genotypes, P.IV 19.9, which is classified as a highly tolerant genotype, recorded better results for all the parameters studied under water deficit conditions at 40 per cent FC. The findings of this study support the classification of these genotypes as highly tolerant, tolerant, and susceptible. These parameters may be used as the most promising indicators to screen for drought tolerance in cocoa. The results of the study revealed that photosynthetic and physiological parameters have a significant role in imparting drought stress tolerance to cocoa. Furthermore, these selected drought-tolerant genotypes can be used in future crop improvement programmes in cocoa.
The Analysis of Relationship Between Critical Thinking Ability in Early Childhood and Thematic Learning Outcomes
Authors: Rissa Megavitri  , Devin Mahendika  , Rahman Pranovri Putra  , Apit Fathurohman  , Yulius Luturmas
Published: June 2023

This study aims to determine the relationship between critical thinking skills and student learning outcomes, as well as to find out how much the level of critical thinking skills has to do with the thematic learning outcomes that the researchers concatenated into learning outcomes for Indonesian language, social studies, and civics in fifth grade elementary school students. This study used the descriptive-correlational method. The tools used to collect data are Likert scales and documents. The sample used is a saturated sample, that is, the entire population is 83 fifth-grade elementary school students. The correlation technique used in this research is product moment correlation, with the t-count results being 3,446 for Indonesian language learning outcomes, 2,819 for social studies learning outcomes, and 8,971 for civics learning outcomes. The results of the correlation between critical thinking skills and Indonesian learning outcomes are 0.253, 0.303 for social studies learning outcomes, and 0.258 for civics learning outcomes. So, the descriptive results are that there is a significant positive relationship between critical thinking skills and learning outcomes in social sciences and civics, with the level of relationship being at a moderate level.
Improving Creative Thinking Skills of Early Childhood by Utilizing Robotic Activities in Learning Process
Authors: Miftahus Surur  , Muhammad Ridhwan  , Achmad Abdul Azis  , Irma Noervadila  , Ruski
Published: June 2023

This study aims to determine the effect of robotics activities on improving the creative thinking skills of early childhood. This study used quanitative research with the Single Subject Design (SSD) method. The research design used in this study is using the A-B-A reversal design. Data collection was carried out using with a pre-test post-test experimental research design without clear control. The results of this study indicate that robotics activities can improve the creative thinking skills of early childhood. Robotics activities can improve creative thinking skills because the implementation of robotics activities is an activity based on constructive and manipulative activities. The characteristics of creative thinking skills that are improved through robotic activities are fluency, flexibility, originality, elaboration, and tenacity and patience. The relationship between robotics activities and creative thinking skills is that robotics activities are designed to follow environmental developments. So that it can bring out creativity in humans in developing ideas and become a means of realizing these creative ideas.
Proprioception and osseoperception in prosthodontics – A review
Authors: Sashi Varsha , Leoney A , Port Louis Leena Rajathy
Published: June 2023

The masticatory system receives neural inputs by means of proprioception and perception. Defective proprioceptive or perceptive input results in dysfunctional or pathological conditions. The prognosis of a prosthodontic restoration depends on the integration of proprioceptive input and motor output. The absence of intradental and periodontal mechanoreception accompanying tooth loss alters the fine proprioceptive control feedback. Complete denture rehabilitation is a compromised restoration which restores function with many lacunae. In contrast to conventional dentures, implant-supported prostheses restore jaw function with improved psychophysiological discriminatory ability, oral stereognosis, and osseoperception.
Options for antiangiogenic therapy of subretinal hemorrhages by of age-related macular degeneration
Authors:   M. Krasnov Research Institute of Eye Diseases, Korobov E.N. , Petrachkov D.V. ,   M. Krasnov Research Institute of Eye Diseases, Alkharky L. ,   M. Krasnov Research Institute of Eye Diseases
Published: June 2023

Purpose. To evaluate the effectiveness of various options for anti-angiogenic therapy in patients with subretinal hemorrhage (SRH) by of age-related macular degeneration (AMD). Material and methods. A total of 15 patients (15 eyes) with SRH by of AMD were treated. The mean duration of a hemorrhage from its onset to the start of treatment was 18.8 ± 10.0 days. The size of the SRH varied from 0.5 to 5 DD. The best corrected visual acuity (BCVA) before treatment varied from hand movement near the face to 0.1. Patients underwent the following treatment options for SRH: 1) anti-VEGF intravitreal injection (IVI) – 8 (53.3%); 2) IVI anti-VEGF + IVI prourokinase + IVI ophthalmic gas (SF6, C2F6) – 7 (46.7%). The average follow-up period for patients after treatment was 10.8 ± 6.3 months. Results and discussion. With the maximum follow-up period after the treatment in 2nd group it was possible to achieve hemorrhage displacement: partial – in 2 (58%) patients, complete – in 5 (71.5%) patients. At the maximum follow-up period, an improvement in BCVA in comparison with the preoperative one was observed in 8 (53.3%) cases, no dynamics – in 4 (26.7%) cases, and negative dynamics – in 3 (20%) cases. All patients underwent anti-VEGF therapy after the start of SRH treatment. Conclusions. The data obtained indicate that the use of antiangiogenic therapy of SRH by of AMD has positive results in improving BCVA and reducing the volume of hemorrhage. The choice of treatment method is determined by the size and duration of the existence of the SRH. It is necessary to continue anti-VEGF therapy in all patients after the start of treatment with SRH by of AMD. Keywords: submacular hemorrhage, age-related macular degeneration, pneumodislocation, anti-VEGF inhibitors, tissue plasminogen activator
Analysis of the causes of eye removal surgeries at the present stage
Authors:   Federal State Budget Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Healthcare of the Russian Federation, Yakovlev I.A. , Revta A.M. ,   State Autonomous Health Institution of the Arkhangelsk Region «Arkhangelsk Clinical Ophthalmic Hospital», Seliverstova D.V. ,   State Autonomous Health Institution of the Arkhangelsk Region «Arkhangelsk Clinical Ophthalmic Hospital», Bezhanidze A.M. ,   State Autonomous Health Institution of the Arkhangelsk Region «Arkhangelsk Clinical Ophthalmic Hospital»
Published: June 2023

Retrospective analysis of the case histories of 243 patients (111 men and 132 women) aged 6 months to 96 years who underwent eye removal operations (22 eviscerations and 221 enucleations) was conducted. In the structure of clinical indications for enucleation and evisceration of the eye dominated severe pyo-inflammatory processes (infectious ulcer with corneal perforation, endophthalmitis, panophthalmitis, chronic sluggish uveitis with the threat of sympathetic ophthalmia) – 46.5 %. The percentage of malignant neoplasm (melanoma and retinoblastoma) is 27.9 %. Painful absolute glaucoma was the cause of enucleation in 18.9 %, severe eye injury in 6.5 % of patients. Radical surgeries were more often performed in women of the older age group with inflammatory pathology and oncopathology, men were more often operated on for painful absolute glaucoma and eye injury. Keywords: еnucleation; еvisceration; аnophthalmia
Features of corneal pathomorphology in secondary dystrophy of traumatic genesis
Authors:   Siberian State Medical University, Tomsk, Russia, Zhigalskaya T.A. , Denisko M.S. ,   Siberian State Medical University, Tomsk, Russia
Published: June 2023

Currently, secondary corneal dystrophy is a common cause of corneal blindness. In addition to a significant decrease of vision, this pathology is accompanied by a significant corneal syndrome and damage to all layers of corneal tissue. The article presents the data of light microscopy of a fragment of the surface layer of pathologically altered corneal tissue obtained during surgical treatment of secondary corneal dystrophy of traumatic genesis. It was found that in this pathology there is a expressed fibrinoid swelling of the main substance and neovascularization of the subepithelial structures of the cornea. Keywords: secondary corneal dystrophy, pathomorphology, fibrinoid swelling, neovascularization
Cases of lack of therapeutic effect of corneal collagen crosslinking in treatment of keratoconus
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Kutuzova Y.V. , Sorokin E.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Dutchin I.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation
Published: June 2023

Purpose. Study of changes in morphometric parameters of cornea in keratoconus before and after corneal collagen crosslinking (CXL). Material and methods. 35 patients (35 eyes) with progressive keratoconus stages 1–3. The indexes of photokeratoscopy were studied in depth (topographer Pentacam (Oculus, Germany). CXL was performed according to the Dresden protocol. A corneal lenticule was used in 6 eyes. The analysis of the studied parameters was carried out initially and after 12 months. Results. By the end of the observation, in all patients, the average values of maximum keratometry (Kmax) decreased statistically significantly from 54.5 to 53.1 diopters, which indicated positive trend. Most indices of keratoconus according to topographer data (ISV, IVA, KI, CKI, IHA, Rmin), as well as the central corneal thickness, on average, significantly decreased. But in 5 patients (all men, mean age 25 years), the Kmax exceeded initial values (from 61.7 to 64.5 diopters), which indicated further progression of keratoconus. The initial values of Kmax in 3 out of 5 of these patients exceeded 57 diopters, which is risk of further progression of keratoconus. Conclusion. With a follow-up period of one year, it was found that CXL in 5 patients (14 %) with keratoconus stages 2-3 turned out to be ineffective. Keywords: keratoconus, photokeratoscopy, corneal collagen crosslinking
Comparative analysis of changes in the number of calls to the emergency department of the OBUZ «Ophthalmological Clinical Hospital – Ophthalmological Center» in Kursk against the background of the COVID-19 coronavirus pandemic
Authors:   OBUZ «Ophthalmological Clinical Hospital – Ophthalmological Center» of Kursk, Loktionova O.N. ,   Kursk State Medical University of the Ministry of Health of Russia, Gerasenkov S.V. ,   OBUZ «Ophthalmological Clinical Hospital – Ophthalmological Center» of Kursk,   Kursk State Medical University of the Ministry of Health of Russia, Bereznikov A.I. ,   OBUZ «Ophthalmological Clinical Hospital – Ophthalmological Center» of Kursk,   Kursk State Medical University of the Ministry of Health of Russia
Published: June 2023

Eye injuries, along with other urgent conditions, are one of the main causes of disability in ophthalmology. The organization of emergency departments in ophthalmic hospitals serves to minimize the time interval between injury and the provision of highly specialized care. Against the background of the COVID-19 pandemic, certain changes have occurred both in the structure of morbidity and in the provision of emergency assistance to the population. The purpose of the work: to study the epidemiology of appeals related to emergency ophthalmological care, according to the emergency department of the OBZ «Ophthalmological Clinical Hospital – Ophthalmological Center» in Kursk in 2012 and 2021 and compare the indicators. Material and methods. As part of the work of the emergency department of eye microsurgery, a retrospective quantitative analysis of appeals with damage to the visual organ and other pathologies was carried out. There is a significant, more than 100-fold increase in the volume of treatment of patients with inflammatory diseases. This is partly due to the transformation of a number of medical institutions into institutions for the treatment of coronavirus infection. COVID-19 infection not only causes inflammatory diseases of various organs and systems, but also contributes to the manifestation of all chronically occurring pathologies. Keywords: emergency care, COVID-19 pandemic, inflammatory diseases.
Comparative analysis of effectiveness research of ranibizumab and aflibercept
Authors:   Research Institute of Eye Diseases, Moscow, Russian Federation, Plyukhova A.A. , Savochkina O.A. ,   Research Institute of Eye Diseases, Moscow, Russian Federation
Published: June 2023

Summary. Intravitreal administration of anti-VEGF drugs is currently the main method of treatment for all types of exudative form of age-related macular degeneration (eAMD). However, most studies did not divide patients. Currently, there are two drugs with a long clinical history of use in Russia for the treatment of neovascular AMD, these are ranibizumab and aflibercept. Data regarding the binding affinity of ranibizumab and aflibercept to VEGF have been inconsistent in in vitro studies. To analyze the effectiveness of aflibercept and ranibizumab in real clinical practice over a three-year follow-up period. Material and methods. The clinical material of the study was the data of examination and treatment of 344 patients (344 eyes) aged 50 to 87 years with a diagnosis of exudative form of age-related macular degeneration on the basis of the Federal State Budget Scientific Institution “NIIGB. Results. During the first treatment, the difference between groups in BCVA (0.51 ± 0.25 for both groups) and CRT (403.3 ± 115.9 for ranibizumab and 364.2 ± 119.6 for aflibercept) during the first year was not noted (p > 0.05). During the third year of observation and treatment in both groups, the same number of IVIs was produced – 3.5. BCVA in the aflibercept group was 0.53 ± 0.30, in the ranibizumab group it was 0.41 ± 0.30 (p < 0.05). In our opinion, the main factor in the stabilization of visual functions in the aflibercept group is more thorough “disease control», while in the ranibizumab group, with a comparable number of injections, visual acuity was lower by the end of the 3rd year of observation, which we attribute to the negative effect of persistent edema, leading to to death of retinal cells. Keywords: age related macular degeneration, anti-VEGF therapy, aflibercept, ranibizumab
Quantitative characteristics of the retinal microvasculature at various stages of diabetic retinopathy
Authors:   Research Institute of Eye Diseases, Moscow, Russian Federation, Pavlov V.G. , Gurevich I.B. ,   Federal Research Center «Computer Science and Control» of the Russian Academy of Sciences FRC CSC RAS, Moscow, Russian Federation, Tleubaev A.T. ,   Federal Research Center «Computer Science and Control» of the Russian Academy of Sciences FRC CSC RAS, Moscow, Russian Federation, Yashina V.V. ,   Federal Research Center «Computer Science and Control» of the Russian Academy of Sciences FRC CSC RAS, Moscow, Russian Federation, Durzhinskaya M.H. ,   Research Institute of Eye Diseases, Moscow, Russian Federation, Khalatyan A.S. ,   Research Institute of Eye Diseases, Moscow, Russian Federation, Petrachkov D.V. ,   Research Institute of Eye Diseases, Moscow, Russian Federation, Budzinskaya M.V. ,   Research Institute of Eye Diseases, Moscow, Russian Federation, Yousef Y.N. ,   Research Institute of Eye Diseases, Moscow, Russian Federation
Published: June 2023

Diabetic retinopathy (DR) is a vision-threatening complication of diabetes mellitus (DM). OCT angiography is the gold standard for diagnostics of microcirculatory changes associated with DR. In this study, AI-based software assessment of OCT-A images was used to analyze images of patients with type 1 diabetes and healthy volunteers. Keywords: diabetic retinopathy, biomarkers, OCT angiography, artificial intelligence
Features of subjective manifestations of computer visual syndrome among students
Authors:   Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of Russia, Ufa, Russia, Shaykhutdinova E.F. , Khusniyarova A.R. ,   Federal State Budgetary Educational Institution of Higher Education «Bashkir State Medical University» of the Ministry of Health of Russia, Ufa, Russia
Published: June 2023

Purpose. To conduct a qualitative and quantitative evaluation of the subjective components of the CVS. Material and methods. 346 people participated in the study, who are students of various higher and secondary educational institutions in Russia, whose average age was 20.6 ± 0.1 years. With the help of a multidimensional author's questionnaire, such groups of CVS symptoms as conjunctival, accommodative, visual-motor, neuroreceptor and neuropsychiatric, as well as the frequency and duration of use of devices were evaluated. Results. The average experience of using digital devices among students was 10.6 ± 0.2 years, the frequency of using «I live with a computer / smartphone» turned out to be the most popular, and the most common manifestations of CVS in each group were complaints of dryness, difficulty focusing at a long distance, blurred vision during visual work, sleep disturbance and eye pain. Conclusion. A preliminary analysis of the results of a multidimensional online questionnaire on the qualitative and quantitative analysis of the subjective components of CVS among students showed the need to take into account and further study such symptoms as neuroreceptor and psychoneurological, which could expand the possibilities of diagnosing CVS and help in the subsequent assessment of clinical complaints of CVS in people using digital devices. Keywords: computer visual syndrome, device, complains, symptoms, questionnaire, dry eye syndrome
Prevention of intraoperative bleeding from neovascularization of the disc in complicated cases of proliferative diabetic retinopathy
Authors:   Federal State Institution «Eye Microsurgery Center named after S.N. Fyodorov» Ministry of Health of the Russian Federation, Kashtan O.V. , Levashov I.A. ,   Federal State Institution «Eye Microsurgery Center named after S.N. Fyodorov» Ministry of Health of the Russian Federation, Petukhova A.A. ,   Federal State Institution «Eye Microsurgery Center named after S.N. Fyodorov» Ministry of Health of the Russian Federation
Published: June 2023

Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in diabetic patients and is characterized by neovascularization particularly in optic nerve head (NVD). NVD may bleed spontaneously or be caused by minimal trauma. During vitrectomy, it is often difficult to stop this type of bleeding, thus surgeons are faced with such a problem as poor visualization and residual hemorrhage in the early postoperative period. Aim was to evaluate the clinical efficacy of the platelet-rich plasma (PRP) use in intraoperative bleeding from the NVD during the surgical treatment of PDR. Material and Methods. The group consists of 12 patients (12 eyes). Preoperative examination of all patients revealed the vitreous hemorrhage as well as the retinal traction detachment according to B-scan. A standard three-port vitrectomy (25 g) was performed, accompanied with the removal of proliferated blood vessels, diathermic coagulation, endolaser coagulation of the retina and an intravitreal injection of PRP on the NVD (PRP obtained by one-step closed centrifugation). Vitreal cavity was tamponaded with air. Results. We achieved an almost complete cessation of bleeding into vitreal cavity from NVD in all participants by using the intravitreal injection of the PRP. Conclusion. Intravitreal injection of PRP on the optic disc during vitrectomy is effective and safe. Keywords: proliferative diabetic retinopathy, PDR , neovascularization of the disc, vitreous hemorrhage, platelet-rich plasma, PRP, vitrectomy
The Benefits of Electronic Medical Records Reviewed from Economic, Clinical, and Clinical Information Benefits in Hospitals
Authors: Ariyanti Novita , Agushybana Farid , Widodo Aris Puji
Published: June 2023

The development and progress of information technology are advancing very rapidly, electronic medical records are one form of these developments and advances in the health sector. A hospital is a place of service in the health sector that performs services related to medical records. Medical records can be made in full and clearly in electronic (digital) form. The implementation of medical record technology can solve many problems in the economic field, clinical, and information of clinical in the hospital system. The high cost of operational and complicated procedures is a crucial problem in the hospital system. So, the advance of medical technology can press high costs, cutting off the manual process to faster and more effective system and efficiency costs of operational. The study uses Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA), with many articles on the same issue. The same issues that can be found at the same topics of articles are probably more than fifty topics of articles. Articles were taken from various sources and database references, including Scopus 2 journals, Science Direct 16 journals, ProQuest 10 journals, Springer Link 3 journals, Google Scholar 36 journals, Research Gate 21 journals, PubMed 31 journals, and Emerald Insight 31 journals. So the total journal database is 133 journals. Then filtering was carried out by identifying the suitability of the journal until it was narrow and 27 articles were selected to be used as a reference in this research.. The purpose of this study is to determine the benefits of applying Electronic Medical Records in terms of economic, clinical, and access to clinical information. Some of the economic benefits include cost savings, effectiveness, and cost efficiency. Clinical benefits include reducing medical errors, improving data readability, improving the quality of care services, and increasing the productivity of medical personnel. And the benefits of accessing clinical information include improving the accessibility of patient history information, improving patient confidentiality, and assisting the decision-making process.
Virtual feedback
Authors: Pałczyńska Anna
Published: June 2023

Feedback is a complex issue that can be discussed from many perspectives. It can be given by teachers to students, by students to teachers, by students to students, by teachers to teachers. Moreover, nowadays thanks to technology our students can be offered automatic feedback that will be given to them immediately upon completing a task. Even though there are several texts dealing with feedback that students receive from teachers, it seems that not much research has been done on other types of feedback. This article aims to start a discussion on the different types of feedback as well as to show ways in which technology can be useful in terms of giving and eliciting feedback.
Analiza slangu polskiej subkultury techno na podstawie materiału źródłowego
Authors: Zarzycki Łukasz , Świątek Artur
Published: June 2023

Niniejsza praca ma na celu wykazanie, iż subkultura technomaniaków lub technomanów jest czymś więcej niż tylko subkulturą młodych ludzi. Członkowie owej subkultury doświadczają często duchowych doznań oraz przemian podczas imprez masowych. Eskapizm uczestników imprez związanych z muzyką techno został przeanalizowany w pracy pod względem językowo-kulturowym. Autorzy sugerują trzy obszary, które mają wpływ na terapeutyczne właściwości imprez masowych oraz doznawanie przez ich uczestników „podróży” (ang. trips). W pracy przeanalizowano 120 słów i zwrotów związanych z muzyką elektroniczną na podstawie materiału źródłowego dostępnego na największym Forum Muzyki Elektronicznej, które istnieje od 2009 roku. Obszerna analiza literatury dotyczącej języka i kultury stanowi tło teoretyczne do analizy subkultury techno i pozwala wskazać, jak blisko związane są ze sobą te dwa terminy.
Usos do G-CSF no tratamento da COVID-19 e o papel de fatores de crescimento hematopoiético na fisiopatologia da doença: uma revisão sistemática / G-CSF’s uses on COVID-19 treatment and the role of hematopoietic growth factors on the disease pathophysiology: a systematic review
Authors: Marques Tatiana Carvalho , Ferreira Eliana Claudia Perroud Morato
Published: June 2023

Introdução: A hematopoese é controlada por determinados fatores, e o isolamento destes leva a uma nova classe de agentes terapêuticos como o fator estimulador de colônias de granulócitos, que age nos neutrófilos. Objetivo: Tendo em vista a importância deste medicamento e da pandemia da COVID-19 atualmente, essa revisão tem como objetivo discutir os possíveis benefícios e riscos do uso do fator estimulador de colônias de granulócitos no tratamento da COVID-19, assim como o papel de fatores de crescimento hematopoiético na fisiopatologia da doença. Método: Foi feita uma revisão sistemática usando como base de dados o PubMed, SciELO e Biblioteca Regional de Medicina, utilizando as palavras-chave: COVID-19 e Granulocyte Colony-stimulating Factor. Resultados: Na ferramenta Biblioteca Virtual em Saúde, foram selecionados dez artigos. Não foi recuperado nenhum estudo da ferramenta SciELO. Na pesquisa pela base de dados PubMed, um artigo se encaixou nos critérios de inclusão. Conclusão: Após análise da literatura, não foi possível comprovar a eficácia do uso de fator estimulador de colônias de granulócitos no tratamento da COVID-19, apesar de, ao que tudo indica, seu uso ser seguro e com poucos efeitos colaterais.Palavras-chave: Filgrastim, COVID-19, Fator estimulador de colônias de granulócitos, SARS-CoV-2.
ABSTRACT:
Introduction: Hematopoiesis is controlled by specific growth factors, and its isolation leads to a new type of therapeutic agents such as the granulocyte colony-stimulating factor, that acts on neutrophils. Aims: In light of the importance of this drug and the COVID-19 pandemic, this review aims to discuss the possible benefits and risks of granulocyte colony-stimulating factor use on COVID-19 treatment, in addition to the role of hematopoietic growth factor on the disease pathophysiology. Method: A systematic review was conducted using the United States National Library of Medicine (PubMed), Scientific Electronic Library Online (SciELO) and Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde (BIREME) as databases, utilizing the keywords COVID-19 and granulocyte colony-stimulating factor. Results: From Biblioteca Virtual em Saúde ten papers were selected. No study was retrieved from SciELO. From the PubMed database, only one paper fit the inclusion criteria. Conclusion: After literature review and analysis, it was not possible to verify the efficacy of granulocyte colony-stimulating factor on COVID-19 treatment, even though it seems to be safe and have few side effects.Keywords: Filgrastim, COVID-19, Granulocyte colony-stimulating factor, SARS-CoV-2.
From Particle-in-a-Box Thought Experiment to a Complete Quantum Theory?
Authors: Chen Jixin
Published: June 2023

The Schrödinger equation provides wavefunctions that describe the behavior of atoms, molecules, and materials, but constructing these wavefunctions by basis sets from fitting experimental data has rendered quantum chemistry predominantly empirical. The computational intensity of this process arises partly from the requirement to integrate wavefunctions across space to calculate energy levels. In this manuscript, a novel equation is proposed that significantly accelerates the computation of energy levels compared to classical quantum mechanics. Leveraging the first law of thermodynamics, which dictates that an equilibrium system maintains its total energy, an energy density function is derived that exhibits spatial uniformity and eliminates the need for normalization and renormalization. Consequently, the energy calculation no longer necessitates the integration of the entire wavefunction and transforms the second-order differential equation into a first-order counterpart. This new equation draws inspiration from the energy conservation method employed in solving classical mechanics problems like the pendulum. Remarkably, it successfully quantizes the energy levels of classical quantum systems, including the particle-in-a-box thought experiment, harmonic oscillator, and free spin, relying on simple rules such as momentum conservation. Therefore, it holds the potential to fit experimental data and reduce computational costs in modern quantum chemistry calculations.
The phosphorescent properties of heteroleptic Ir (III) complexes: uncovering their emissive species
Authors: Kumar Prashant , Pérez-Escribano Manuel , van Raamsdonk Davita M. E. , Escudero Daniel
Published: June 2023

In this contribution we assess the computational machinery to calculate the phosphorescence properties of a large pool of heteroleptic [Ir(C^N)2(N^N)]+ complexes (where N^N is an ancillary ligand and C^N is a cyclometalating ligand) including their phosphorescent rates and their emission spectra. Efficient computational protocols are next proposed. Specifically, different flavors of DFT functionals were benchmarked against DLPNO-CCSD(T) for the phosphorescence energies. Transition density matrix and decomposition analysis of the emitting triplet excited state enables to categorize the studied complexes into different cases, from e.g., predominant triplet ligand-centered (3LC) character to predominant charge-transfer (3CT) character, either of metal-to-ligand charge transfer (3MLCT), ligand-to-ligand charge transfer (3LLCT) or a combination of the two. We have also calculated the vibronically resolved phosphorescent spectra and rates. Ir (III) complexes with predominant 3CT character are characterized by less vibronically-resolved bands as compared to those with predominant 3LC character. Furthermore, some of the complexes are characterized by close-lying triplet excited states, so that the calculation of their phosphorescence properties poses additional challenges. In these scenarios, it is necessary to perform geometry optimizations of higher-lying triplet excited states (i.e., Tn). We demonstrate that in the latter scenarios all the close-lying triplet species must be considered to recover the shape of the experimental emission spectra. The global analysis of computed emission energies, shape of the computed emission spectra, computed rates, etc. enable us to unambiguously pinpoint for the first time the triplet states involved in the emission process and to provide a general classification of Ir (III) complexes with regards to their phosphorescent properties.
Describing nuclear quantum effects in vibrational properties using molecular dynamics with Wigner sampling
Authors: Tikhonov Denis , Vishnevskiy Yury
Published: June 2023

In this work we discuss the generally applicable Wigner sampling and introduce a new, simplified Wigner sampling method, for computationally effective modeling of molecular properties containing nuclear quantum effects and vibrational anharmonicity. For various molecular systems have been performed test calculations of (a) vibrationally averaged rotational constants, (b) vibrational IR spectra and (c) photoelectron spectra. The performance of Wigner sampling has been assessed by comparing with experimental data and with results of other theoretical models, including harmonic and VPT2 approximations. The developed simplified Wigner sampling method shows advantages in application to large and flexible molecules.
PI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase
Authors: Ghosh Avishek , Venugopal Aishwarya , Shinde Dhananjay , Sharma Sanjeev , Krishnan Meera , Mathre Swarna , Krishnan Harini , Saha Sankhanil , Raghu Padinjat
Published: June 2023

Phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 5-phosphate (PI5P) are low-abundance phosphoinositides crucial for key cellular events such as endosomal trafficking and autophagy. Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) is an enzyme that regulates PI5P in vivo but can act on both PI5P and PI3P in vitro. In this study, we report a role for PIP4K in regulating PI3P levels inDrosophila. Loss-of-function mutants of the onlyDrosophilaPIP4K gene show reduced cell size in salivary glands. PI3P levels are elevated indPIP4K29and reverting PI3P levels back towards WT, without changes in PI5P levels, can rescue the reduced cell size.dPIP4K29mutants also show up-regulation in autophagy and the reduced cell size can be reverted by depleting Atg8a that is required for autophagy. Lastly, increasing PI3P levels in WT can phenocopy the reduction in cell size and associated autophagy up-regulation seen indPIP4K29. Thus, our study reports a role for a PIP4K-regulated PI3P pool in the control of autophagy and cell size.
Advances in Biophysics
Authors: R Dr S Chitra
Published: June 2023

This book is intended as a reference book for all students in Physics and Biological field. The present book, A Textbook of Biophysics gives a vibrant scientific field where scientists from many fields including math, chemistry, physics, engineering, pharmacology, and materials sciences, use their skills to explore and develop new tools for understanding how biology—all life—works. The Biophysics major also serves as an excellent pathway for students intending to pursue postgraduate study. 'Biophysics' implies physics applied to biology: is that what biophysics is? Yes, biophysics is the study of biological systems and biological processes using physics-based methods or based on physical principles.
No Relative Age Effect Among Brazilian Elite Female Futsal Athletes
Authors: Alves Rodrigues Mylena Aparecida , de Oliveira Vivian , de Castro Ribeiro Lucas , William Bortolan Kevin , Manuel Clemente Filipe , Lima Ricardo Franco , Savassi Figueiredo Lucas , de Oliveira Castro Henrique
Published: June 2023

Our aim in this study was to analyze: (i) the presence of the relative age effect (RAE) on the Brazilian elite female futsal athletes according to their team’s final position in the National Championship, and (ii) the relationship between the presence of the RAE and the athletes’ tactical individual performance. Participants were 77 female Brazilian elite futsal athletes that competed in the 2021 National Championship. Data included their dates of birth aggrupation by quartiles (Q1-Q4), their team’s final position in the National Championship, and their tactical individual performance indicators (time played, goals scored, assists, steals, shots on goal, unbalanced passes, and challenges won in 1vs1). Analyses of the overall sample indicated that RAE was not prevalent in this context since the observed birthdate distribution was not different from the expected one (p=.796). When the final placement in the championship was considered, the birthdate distributions were also not different from the expected for both the top-ranked (p=.572) and low-ranked (p=.679) team athletes. Regarding athletes’ tactical individual performance, no differences were found between the athletes with early and late birthdates for any of the variables analysed (p>.05). Our results suggest that RAE has no impact on this specific sport context, which should be interpreted as a positive factor since female futsal athletes seem to have the same chance of achieving the elite level in Brazil, regardless of their birthdates.