bluuebunny/crossref_metadata_2025 huggingface dataset:
The Power of “We”: Using Inclusive Pronouns in Norm-Based Messages to Promote PrEP-Related Information Seeking Among Men Who Have Sex With Men
Authors: Ji Yadong
Published: August 2023

Pre-exposure prophylaxis (PrEP) is an effective medicine preventing HIV transmission. This study designs and tests normative messages that promote PrEP-related information seeking among men who have sex with men (MSM) (n = 410). Two factors were manipulated in normative messaging: type of norm (descriptive [“people do”] vs. injunctive [“people should”]) and type of pronoun (individual “you” vs. collective “we”). The results favored the use of descriptive normative appeal and collective pronouns in normative message design. For health campaigns that target MSM's PrEP-related behaviors, this study suggests that descriptive norms may increase behavioral changes whereas injunctive norms may appear intrusive and backfire. At the same time, using inclusive agency assignment (e.g., pronouns) may encourage HIV prevention through provoking solidarity considerations.
A praça como espaço de identidade e memória da cidade
Authors: Luz Emanuely Ferreira dos Reis , Cutrim Kláutenys Dellene Guedes , Luz Mariely Ferreira dos Reis
Published: August 2023

Este artigo busca investigar como a praça, enquanto espaço público, pode ser considerada um lugar capaz de contribuir para a construção da identidade e da memória coletiva das cidades. De caráter descritivo e bibliográfico, esta investigação procura, de forma interdisciplinar, reunir a concepção de autores das áreas da geografia, do urbanismo, da identidade e da memória. Para tanto, a constante busca em referencial bibliográfico proporcionou a constituição de reflexões mais significativas sobre os conceitos de espaço, espaço público, praça, identidade e memória, contribuindo para o entendimento das identidades fragmentadas dos habitantes na pós-modernidade e das suas memórias individuais. Esses fatores permitem que a praça ganhe sentido, seja um espaço dinâmico, plural e híbrido, se constituindo um lugar que tem a capacidade de promover as relações entre as pessoas, a ponto de contribuir para o surgimento de memórias coletivas, fortalecedoras das relações sociais nos espaços públicos das cidades.
Producción y consumo alternativo de alimentos: la búsqueda de la producción de un espacio diferencial
Authors: Vieira Sidney Gonçalves , Arzeno Mariana Beatriz , Oliveira Giovana Mendes de , Troncoso Claudis Alejandra
Published: August 2023

El artículo reflexiona acerca de procesos en torno a la producción de alimentos que, iniciados y llevados adelante por diferentes actores en distintos contextos, generan transformaciones sociales y espaciales que pueden interpretarse como procesos de creación de espacios diferenciales. Tomamos dos casos que dan cuenta de la diversidad de expresiones que pueden tomar los procesos por los cuales diferentes actores, con distintas estrategias, en diferentes contextos desafían formas dominantes de organizar la producción de alimentos recurriendo a productos, técnicas y saberes asociados con lugares, culturas y tradiciones específicas. Estas experiencias han sido abordadas a partir de la generación de información empírica basada en entrevistas personales con los actores clave de estos procesos, así como la observación de los ámbitos productivos y de los eventos y lugares en que se concreta la producción y la comercialización de los productos. Ambos casos han sido analizados teniendo en cuenta dimensiones significativas de los procesos por los cuales se han generado transformaciones socio-espaciales que dan cuenta de la conformación de ámbitos diferentes a aquellos organizados por lógicas dominantes.
Tempo, variação e esquecimento: seis operações da ética da memória
Authors: Spohn Cezar Brida Emanoele , Costa Luis Artur
Published: August 2023

Este artigo aborda a memória desde uma perspectiva trágica que a afirma enquanto um devir em constante transformação. Na sua relação indissociável e paradoxal com o esquecimento, busca-se visibilizar a possibilidade de metabolização do vivido e de incorporação das formas constantemente devolvidas às forças de criação e destruição inerentes às paisagens de dois vilarejos atravessados pela ferrovia: São Salvador e Paranapiacaba. Seis operações distintas acompanham o percurso de um pensamento debruçado sobre imagens e intensidades que se aglutinam em camadas: o tempo não é compreendido mais em estágios, mas em estratos que podem ser escavados e reunidos de modo fragmentário. São elas: a evaporação, a decomposição, a oxidação, a preservação, a digestão e a decomposição. Não existem homogeneidades e generalizações: cada qual enseja a sua própria travessia num ritmo dessemelhante e assimétrico, assim como cada qual estabelece as suas alianças, rizomas e desvios no encontro com as sobrevivências e suas metamorfoses.
Disputa pelo passado e “efeito bumerangue”: um estudo sobre o ex-centro clandestino de detenção Dopinha (Porto Alegre, 1960-...)
Authors: Carneiro Anita Natividade , Bauer Caroline Silveira
Published: August 2023

Este artigo reflete sobre a construção da memória social da ditadura civil-militar brasileira e as possibilidades de ensino e aprendizado a partir de iniciativas de reconhecimento de espaços que materializam determinados relatos sobre o período, notadamente as cartografias de memória. Analisa-se não somente as dinâmicas entre a lembrança e o esquecimento que permeiam as intencionalidades de diferentes agentes, mas também as formas de representação desse passado e para o ensino de história em espaços não-formais. O caso escolhido para estudo são as batalhas memoriais a respeito do centro clandestino de detenção Dopinha, localizado em Porto Alegre, Brasil, e sua definição como um dos pontos que compõem o projeto Caminhos da Ditadura em Porto Alegre. Argumenta-se que as disputas sobre a narrativa da ditadura são permanentes, e que iniciativas como o Caminhos contribuem na consolidação de direitos e na reparação histórica ao explicitar o potencial educativo das cidades.
O tambor de sopapo e a ressignificação de memórias traumáticas
Authors: Tomiello Fernanda , Polidori Maurício Couto , Polidori Miguel Delanoy
Published: August 2023

O tambor de sopapo é um instrumento de grandes dimensões, feito originalmente com tronco de árvore e couro, cuja origem é associada às charqueadas. Este artigo aborda o seu papel na cultura, memória e identidade da comunidade afro-sul-riograndense, percorrendo sua trajetória, desde suas origens até a contemporaneidade. A discussão aponta o sopapo como um dos elos que conecta a herança africana, as memórias traumáticas do período da escravidão e o contexto cultural contemporâneo. Nesse caminho, o risco de esquecimento se revela como potência na promoção de uma reinvenção e reinserção do tambor como elemento identitário, em diferentes situações e lugares. As conclusões indicam que a memória e a identidade associadas ao sopapo parecem se metaforizar na intensidade e duração do seu som grave, ou seja, na sua capacidade de resistência e reinvenção em cada contexto, conectando gerações.
Prior Knowledge Uses Prestimulus Alpha Band Oscillations and Persistent Poststimulus Neural Templates for Conscious Perception
Authors: Shen Lu , Wu Zehua , Yue Zhenzhu , Li Bing , Chen Qi , Han Biao
Published: August 2023

Prior knowledge has a profound impact on the way we perceive the world. However, it remains unclear how the prior knowledge is maintained in our brains and thereby influences the subsequent conscious perception. The Dalmatian dog illusion is a perfect tool to study prior knowledge, where the picture is initially perceived as noise. Once the prior knowledge was introduced, a Dalmatian dog could be consciously seen, and the picture immediately became meaningful. Using pictures with hidden objects as standard stimuli and similar pictures without hidden objects as deviant stimuli, we investigated the neural representation of prior knowledge and its impact on conscious perception in an oddball paradigm using electroencephalogram (EEG) in both male and female human subjects. We found that the neural patterns between the prestimulus alpha band oscillations and poststimulus EEG activity were significantly more similar for the standard stimuli than for the deviant stimuli after prior knowledge was provided. Furthermore, decoding analysis revealed that persistent neural templates were evoked after the introduction of prior knowledge, similar to that evoked in the early stages of visual processing. In conclusion, the current study suggests that prior knowledge uses alpha band oscillations in a multivariate manner in the prestimulus period and induces specific persistent neural templates in the poststimulus period, enabling the conscious perception of the hidden objects.

SIGNIFICANCE STATEMENTThe visual world we live in is not always optimal. In dark or noisy environments, prior knowledge can help us interpret imperfect sensory signals and enable us to consciously perceive hidden objects. However, we still know very little about how prior knowledge works at the neural level. Using the Dalmatian dog illusion and multivariate methods, we found that prior knowledge uses prestimulus alpha band oscillations to carry information about the hidden object and exerts a persistent influence in the poststimulus period by inducing specific neural templates. Our findings provide a window into the neural underpinnings of prior knowledge and offer new insights into the role of alpha band oscillations and neural templates associated with conscious perception.
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3
Authors: Perlee Sarah , Kikuchi Sota , Nakadai Tomoyoshi , Masuda Takeshi , Ohtsuki Sumio , Matsumoto Makoto , Rahmutulla Bahityar , Fukuyo Masaki , Cifani Paolo , Kentsis Alex , Roeder Robert G , Kaneda Atsushi , Hoshii Takayuki
Published: August 2023

The H3K4 methyltransferase SETD1A plays a crucial role in leukemia cell survival through its noncatalytic FLOS domain‐mediated recruitment of cyclin K and regulation of DNA damage response genes. In this study, we identify a functional nuclear localization signal in and interaction partners of the FLOS domain. Our screen for FLOS domain‐binding partners reveals that the SETD1A FLOS domain binds mitosis‐associated proteins BuGZ/BUB3. Inhibition of both cyclin K and BuGZ/BUB3‐binding motifs in SETD1A shows synergistic antileukemic effects. BuGZ/BUB3 localize to SETD1A‐bound promoter‐TSS regions and SETD1A‐negative H3K4me1‐positive enhancer regions adjacent to SETD1A target genes. The GLEBS motif and intrinsically disordered region of BuGZ are required for both SETD1A‐binding and leukemia cell proliferation. Cell‐cycle‐specific SETD1A restoration assays indicate that SETD1A expression at the G1/S phase of the cell cycle promotes both the expression of DNA damage response genes and cell cycle progression in leukemia cells.
Public Exposure to Natural Radioactivity Near Uranium Deposits in Manyoni Area, Central Tanzania
Authors: Sawe Shovi
Published: August 2023

Assessment of public exposure to background radiation was performed in Manyoni, Tanzania to address public concerns following the discovery of uranium deposits in their neighborhoods. Results show that the highest concentrations of radionuclides are 112, 95 and 463 Bq.kg-1 for 226Ra, 232Th and 40K, respectively. The highest annual effective dose to the public is 2.91 mSv.y-1 with a mean value of 1.29 mSv.y-1. Authorities may use these results to address public concerns as well as the baseline information. Further investigations on public exposures in Manyoni are recommended.
Realitas Keagamaan Amanat Keagungan Ilahi dalam Perspektif Ninian Smart
Authors: Nurdiana Rina , Kahmad Dadang , Syukur Abdul , Huriani Yeni
Published: August 2023

Penulisan artikel ini dilatarbelakangi fenomena bermunculannya kelompok keagamaan di Indonesia saat ini, salah satunya yaitu kelompok Amanat Keagungan Ilahi (AKI) yang berada di Desa Cangkuang Kecamatan Leles Kabupaten Garut. Kelompok ini mempunyai aspek esoteric dan eksoterik yang khas dan berbeda terutama pada aspek ritual dan ekeperensial sehingga kelompok ini di sorot cukup tajam oleh masyarakat setempat. Tujuan penulisan artikel ini untuk mendeskripsikan fenomena kelompok Amanat Keagungan Ilahi yang berkaitan dengan  7 dimensi keagamaan Ninian Smart mencakup dimensi ritual, ajaran, expernsial, mitos dan sosial kelembagaan dan dimensi material   para penganutnya. Hasil analisis menunjukkan bahwa AKI merupakan gerakan keagamaan di mana pengikutnya harus melewati ritual berupa pewarisan, mandi tobat, khalwat guha dan khalwat alam menjadi tahapan yang sangat sacral yang harus dilalui oleh anggota AKI yang bersungguh sungguh dalam mendekatkan diri kepada Allah SWT. Prinsip dasar tujuan ajaran AKI adalah untuk mencapai suci hati, suci ucap, dan suci akhlaq. Melalui penelitian lapangan, wawancara mendalam serta obervasi menyimpulkan bahwa corak keagamaan kelompok AKI mengandung unsur percaya kepada alam ghaib, tradisi nenek moyang, mengandalakan olah pikir dan olah rasa serta mengutamakan urusan batin dari pada amalan lahir. Meyakini adanya wahyu berupa wangsit yang turun bagi pengikut yang terpilih.
Cohomology algebra of mapping spaces between quaternion Grassmannians
Authors: Maphane Oteng
Published: August 2023

Let Gk,n(ℍ) for 2≤k<n denote the quaternion Grassmann manifold of k-dimensional vector subspaces of ℍn. In this paper we compute, in terms of the Sullivan models, the rational cohomology algebra of the component of the inclusion i: Gk,n(ℍ) → Gk,n+r(ℍ) in the space of mappings from Gk,n(ℍ) to Gk,n+r(ℍ) for r≥1 and, more generally, we show that the cohomology of Map(Gk,n(ℍ),Gk,n+r(ℍ);i) contains a truncated algebra ℚ[x]x4r+n+k^{2}-nk for n≥4.
Enhancing University Students’ Functional Fitness by Applying Health Programs Based on Individual Student Heart Rate Monitoring Data
Authors: Otaraly Svetlana , Alikey Aibek , Sabyrbek Zhanna , Poteliūnienė Sniegina
Published: August 2023

The purpose of this work was to assess the impact on the students’ functional fitness of a one academic year student health-enhancing program based on equipping students with theoretical and methodological knowledge which allows them to analyze the dynamics of their own functional state and interpret digital feedback received from heart rate monitors. Studies have proven that receiving timely feedback of heart rate during the implementation of the training program, is a promising direction to enhance students functional fitness. The obtained research data can help to better understand how providing digital feedback during exercise can help improve student health and self-management skills that are important for students when planning independent physical activity programs.
Piloting a New Virtue Education Curriculum for 5–15-Year-Old Students: What are the Most Challenging Issues in Its Delivery?
Authors: Surikova Svetlana , Sidorova Anna
Published: August 2023

The article analyses Latvian teachers’ opinions regarding the feasibility of a virtue education curriculum for students aged 5–15 years, which they piloted in spring 2021, and identifies the challenges faced when implementing the virtue education curriculum during the COVID-19 pandemic. The findings showed that the curriculum could be delivered successfully in both modalities – face-to-face and online – since the teachers’ approaches were creative and transformative in addressing all the challenges identified.
HYPERGOLIC IGNITION OF SOLID FUELS WITH REACTIVE ADDITIVES USING HYDROGEN PEROXIDE
Authors: Lin Wei-Che , Young Gregory
Published: August 2023

Hypergolic ignition offers significant benefits for hybrid rockets since it eliminates the need for external
ignition devices or catalyst beds. Numerous studies have demonstrated promising results when
utilizing various reactive additives and oxidizers. Nevertheless, the impact of fuel temperature and
particle size on ignition performance, which is critical in practical applications, is often overlooked.
In this study, we explored the ignition behavior of a metal hydride-based hypergolic fuel with rocketgrade
hydrogen peroxide (RGHP) as the oxidizer. The solid fuel was composed of low-density polyethylene as the binder and sodium borohydride as the reactive additive. Through image processing, we analyzed the ignition behavior by measuring the ignition delay time in droplet tests using different
concentrations of the additives, particle sizes, and initial fuel surface temperatures. Three types of ignitions
were observed, and all of the droplet tests were successfully ignited. To examine the initial fuel
temperature and powder particle size effects on the ignition, we varied the initial temperature of the
fuel pellet and composition percentage of two different particle sizes in the powder. Our experimental
findings suggest that both the initial fuel surface temperature and powder particle size play a crucial
role in the hypergolic ignition delay time.
INVESTIGATION OF THERMAL DISPERSION FOR STEADY AND PULSATING WATER FLOW IN METAL FOAM
Authors: Arbak Altay , Dukhan Nihad
Published: August 2023

The dispersion coefficient in metal foam is critical for analysis and design using the volume-averaged equations. This coefficient is hardly investigated for steady flow, and has not been reported for non-steady flows in metal foam. This paper presents experimental and numerical investigations on the thermal dispersion coefficient in a metal-foam rectangular channel for steady and pulsating water flow. The foam channel was asymmetrically heated from one side representing a heat sink. The heating was accomplished by applying a constant heat flux. For the steady-state investigation, Reynolds number based on the hydraulic diameter of the channel ranged from 365 to 1164. For this range, the experimental thermal dispersion was obtained and given in the form of a correlation. For the pulsating flow investigation, the flow frequency ranged from 0.07 to 0.17 Hz with a maximum velocity amplitude of 0.07 m/s. The thermal dispersion coefficient was obtained experimentally for the pulsating flow in metal foam, most likely for the first time. Results have shown that the velocity amplitude has a significant effect on the thermal dispersion coefficient, whereas the frequency has a limited effect. The dispersion coefficient for pulsating flow was significantly higher than that for steady-state flow, and the difference between the two increased with Reynolds number. This increase in dispersion for pulsating flow is responsible in part for the increased heat transfer.
Investigation of deformation coordination between optical fibre and borehole sand backfill
Authors: Yimit Hasanjan , Zhang Dan , Luo Qi , Gong Xulong , Wang Haoyu , Liao Haiyang
Published: August 2023

Land subsidence has threatened the safety of municipal infrastructures and even that of inhabitants. As one of the deformation monitoring methods, distributed optical fibre sensing (DOFS) technology has been developed for the investigation of land subsidence. The deformation coordination between the optical fibre and soil (DCf-s) under different conditions is critical for land subsidence monitoring with DOFS. In this paper, a medium-sized triaxial apparatus was modified for testing the DCf-s. Consolidated drained triaxial tests were conducted to investigate the effect of sand types on the DCf-s. By linearly fitting the deformation of the sensing cable with that of the triaxial specimen, the other factors that affect the DCf-s, such as the confining pressure, dry or wet state of the soil and cyclic variation of the loads, can be discussed. The experiments reveal that better DCf-s comes with a larger particle size, poor gradation of sand and larger confining pressure. The DCf-s of wet sand is better than that of dry sand. The DCf-s coefficient tends to be stable with an increase of loading cycles. The DCf-s obtained and its dependence on influencing factors can be used to modify the measured cable strain in practical land subsidence monitoring with DOFS.
Dolor de Pie e Imposibilidad para la deambulación luego de hiperflexión plantar
Authors:   Hospital General del Sur de Quito, IESS, Solá Navarrete Ruth Aydeé , Moreano Sánchez Daniel Bolívar ,   Hospital Guasmo Sur, Mendoza Arrieta Guido Ricardo ,   Hospital General del Sur de Quito, IESS, Ochoa-Andrade Miguel ,   Hospital General del Sur de Quito, IESS
Published: August 2023

Paciente femenino, ama de casa, de 39 años de edad, biotipo pícnico, con antecedente de hipotiroidismo en tratamiento con levotiroxina 50 mcg diarios, ingresa por emergencia de una casa de salud de tercer nivel por traumatismo indirecto de pie izquierdo con mecanismo de hiperflexión plantar con carga axial añadida lo que provoca dolor intenso e imposibilidad para la deambulación.
[Research Note] A study on the behavioral characteristics of active senior tourists
Authors:   The Tourism Sciences Society Of Korea, Chang Pyong-Kwon
Published: August 2023

The purpose of this study is to identify the profile of active seniors who drive the tourism market and to analyse the behavioural attributes of active seniors in the tourism market. In this study, active seniors are defined as people in the 50s and 60s who participate in social activities based on time and economic conditions. They are mainly interested in leisure rather than work, pursue various hobbies, and interact with other cultures and generations. Many studies have shown that active seniors account for 20.6% to 32.0% of the total tourism market. In the future, the scale of active senior tourism will continue to increase and will drive the overall tourism market. In addition, the tourism behaviour of active seniors is expected to be smart, creative and interactive. In conclusion, the tourism industry needs to build a business system 2.0 for active seniors.
Pain Control and Sedation in Neuro Intensive Critical Unit
Authors: Park Soo-Hyun , Kim Yerim , Kim Yeojin , Bae Jong Seok , Lee Ju-Hun , Kim Wookyung , Song Hong-Ki
Published: August 2023

Neurocritical patients who can self-report pain use the 0-10 numerical rating scale (NRS, verbal or visual form). However, critically ill patients whose nervous systems cannot express pain use the behavioral pain scale (BPS) and the critical care pain observation tool (CPOT) behavioral pain assessment tools. These tools reveal pain-related changes in movement, facial expression, posture, and physiological indicators such as heart rate, blood pressure, and respiratory rate. In pain control, it is first essential to reduce unnecessary painkillers through non-drug therapy and maximize the effect of the administered analgesics. For nonneuropathic pain, narcotic analgesics such as fentanyl, hydromorphone, morphine, and remifentanil are administered intravenously. Gabapentin, pregabalin, and carbamazepine are recommended along with narcotic analgesics for neuropathic pain control. In addition, nonnarcotic analgesics for multi-modal analgesia are used to reduce the use of narcotic analgesics or the side effects of narcotic analgesics. In the intensive care unit (ICU), the sedation-agitation scale (SAS) and the Richmond agitation-sedation scale (RASS) are used to determine the depth of sedation to be maintained during shallow or deep sedation, considering the condition of the critically ill patient. When selecting sedatives for critically ill patients, preferentially consider nonbenzodiazepines such as propofol or dexmedetomidine rather than benzodiazepines such as midazolam or lorazepam. In addition, patients use painkillers or sedatives for over a week, and neurological changes or physiological dependence may occur. Therefore, clinicians should evaluate the critically ill patient’s condition, and sedatives and painkillers should be reduced or discontinued.
Seizure Occurring 4 Days after Discontinuation of Long-term High-dose Zolpidem
Authors: Kang Kyung Ho , Kim Myeong-Kyu , Hong Jong hwa , Jung Jisu , Kang Kyung Wook
Published: August 2023

Zolpidem is widely used for insomnia and is known to have relatively few side effects. There have been several reports of side effects, but only a few for withdrawal symptoms. A 41-year-old woman developed convulsions 4 days after discontinuing zolpidem. She was taking more than 10 times the standard dosage. After electroencephalography monitoring without antiseizure medications, she showed no more seizures. This case highlights the danger of zolpidem withdrawal and warns about the easy accessibility of zolpidem for individuals.
Endogenous tagging of the YIPF4 gene with mNEON Green and imaging of these cells by microscopy v2 v1
Authors: JW Harper
Published: August 2023

This protocol describes a method to create cells in which the YIPF4 gene has been endogenously tagged with mNEON fluorescent protein. CRISPR-based gene editing was used to introduce mNEON Green into the N-terminus of YIPF4 in WT and FIP200-/- HEK293T cells. We also describe a protocol for imaging of mNEON-YIPF4 in Golgi using the Golgi marker GOLGB1.
Persicaria minor F-box Gene Pmf-box1 Indirectly Affects Arabidopsis thaliana LOX-HPL Pathway for Green Leaf Volatile Production
Authors: Abd Hamid Nur Athirah , ul Hassan Muhammad Naeem , Zainal Zamri , Ismail Ismanizan
Published: August 2023

Green leaf volatiles (GLVs) play an essential role in plant defence, plant-plant interaction and plant-insect interaction. The plant releases GLVs and inhibits the growth and propagation of plant pathogens. In this study, overexpression of PmF-box1 in wild type A. thaliana showed the downregulation of genes involved in the lipoxygenase-hydroperoxide lyase (LOX-HPL) pathway, which contributes to the biosynthesis of GLVs. It resulted in a marked reduction of hexanal production in the PmF-box1-overexpressing plant. The expression pattern of LOX-HPL branch genes in the kelch-repeat modified PmF-box1 (KMF)-overexpressing plant showed a pattern much closer to the expression of LOX-HPL branch genes in the vector control (VC) plant. It was shown that the functional KMF protein sequence was not responsible for the significant reduction of all GLVs including hexanal, 1-hexanol, (Z)-3-hexen-1-ol, and the carbon 5 (C5) volatile, 1-penten-3-ol, in plants overexpressing KMF. Furthermore, this study also showed that the relative proportion of production of 1-penten-3-ol to hexanal was higher in the PmF-box1-overexpressing plant. Based on the current comparative literature search, PmF-box1 does not appear to interact directly with the proteins or transcription factors of the LOX-HPL pathway. On the other hand, PmF-box1 interacts with SAMS1, which subsequently influences the HPL pathway enzyme genes. Thus, this study highlights the potential roles of PmF-box1 in the manipulation of GLV productions.
Activity and Safety of Cinchonine Nanostructured Lipid Carriers as a Hair Growth Stimulant in Mice Model of Androgenetic Alopecia
Authors: Hariyanti Hariyanti , Rachmat Mauludin Rachmat Mauludin , Yeyet Cahyati Sumirtapura Yeyet Cahyati Sumirtapura , Neng Fisheri Kurniati Neng Fisheri Kurniati
Published: August 2023

Androgenetic alopecia (AA) is a hair growth disorder characterized by hair loss and miniaturization of the size of follicles and dermal papillae. Cinchonine is a quinoline alkaloid that can increase VEGF production and potential as a hair growth stimulant. This study aimed to determine the morphology, penetration (in vitro), as well as safety and activity of cinchonine nanostructured lipid carriers (CN-NLC) serum as a hair growth stimulant. Preparation of CN-NLC serum using a combination of micro-emulsification and ultra-sonification methods, characterization of CN-NLC serum included morphology and closed hair follicle diffusion methods. Dermal and eye irritation test using New Zealand rabbit strain with primary irritation index parameters. Hair growth stimulant activity test using Swiss Webster mice strain, induced with the hormone testosterone. Observations were performed at 7, 14, and 21 days with hair length and histology parameters. CN-NLC serum morphology is a spherical shape with size ±500 nm, diffusion of serum CN-NLC (open hair follicles) of 23.92±0.84%; (close hair follicles) of 11.37±2.29%; and CN solution of 6.00±0.72%. CN-NLC serum are non-irritant with a primary irritation index of 0.0. Activity tests showed hair length on days 7; 14 and 21 were increased by 20.24-23.74%; 33.47-36.43%, and 39.30-39.97% (P≤0.05). Histological data showed an increase in the number and size of both dermal papillae and hair follicles compared to the control group. CN-NLC serum can improve the penetration of CN into hair follicles. CN-NLC serum is safe and effective as a hair growth stimulant in the treatment of AA.
Properties of Spray-Dried Iron Microcapsule using Hydrolysed Glucomannan as Encapsulant: Effect of Feed Viscosity
Authors: Dyah Hesti Wardhani Dyah Hesti Wardhani , Irsyadia Nindya Wardana Irsyadia Nindya Wardana , Hana Nikma Ulya Hana Nikma Ulya , Andri Cahyo Kumoro Andri Cahyo Kumoro , Nita Aryanti Nita Aryanti
Published: August 2023

As one of the polysaccharides with high viscocity, even in low concentration, glucomannan could block the nozzle and hinder its application as spray-dried encapsulant. The present research aimed to investigate the effect of viscosity of hydrolysed glucomannan as a spray-dryer feed on properties of encapsulated iron particles. Glucomannan was hydrolysed using cellulase to obtain various viscosities (83-222 cP) and used for encapsulating iron. Enzymatic hydrolysis reduced the glucomannan's glass transition temperature and transmittance values of O-H, C-O, and C-H groups. Increasing the viscosity lightened the particle colour, and improved encapsulation efficiency and mean particle diameter, however, reduced moisture content and bulk density. The highest encapsulation efficiency (99.95%) was obtained using the most viscous encapsulant (222 cP). Thicker encapsulants produced larger particles with more wrinkles on the surface but performed better in protecting iron. Solubility and swelling of the particles were higher in neutral solution (pH=6.8) than in an acidic one. The degree of iron degradation was around 70% after 10 months of storage. These results suggested the use of an appropriate viscosity of hydrolysed glucomannan not only allow it to be sprayed but also showed a potency to protect the iron from solubility in acid ambient and degradation during the storage.
Kinetic Study of Total Phenolic Content from Piper betle Linn. Leaves Extract Using Subcritical Water
Authors: Rahmah Nur Lailatul , Mustapa Kamal Siti Mazlina , Sulaiman Alifdalino , Taip Farah Saleena , Siajam Shamsul Izhar
Published: August 2023

The green plant-based extraction of phenolic compounds is still challenging and attractive due to their benefit. The mechanism controlling of desorption rate of phenolic compounds, measured as total phenolic content (TPC), from Piper betle Linn. (PBL) leaves using subcritical water, and a one-site kinetic desorption model (first order) was studied. One-site kinetic desorption model has well explained the extraction mechanism of phenolic compounds from PBL leaves using subcritical water through desorption and diffusion mechanism. This model fits with the experimental data and presents a good description of the extraction mechanism with R-squared of 0.94. The recovery of TPC from PBL leaves using subcritical water was influenced by intraparticle diffusion, temperature, and extraction time. The desorption rate constant in the one-site kinetic desorption model increased from 100 to 200 °C (0.3975±0.02 to 3.3045±0.00 min-1) and then decreased to 250 °C (3.2093±0.00 min-1). The highest TPC was recovered quickly for 5 min at 200 °C. In addition, a high yield of TPC was also obtained at a slow desorption process for 30 min at a lower temperature of 175 °C. The low activation energy for the diffusion of phenolic compounds from PBL leaves of this study was 8.964 kJ/mol. This result showed that the one-site kinetic desorption model of subcritical water extraction has an excellent opportunity to be applicable in phenolic compounds recovery from PBL leaves. The one-site kinetic desorption rate constant and mathematical kinetic model equation achieved in this study might control the quality of phenolic compounds extracted from PBL leaves through subcritical water.
Methods of Evaluating Adaptation and Accuracy of Additive Manufactured Removable Partial Dentures: A Scoping Review
Authors: Elhadery Safa , Yacob Norlela , Safii Syarida Hasnur , Ibrahim Norliza , Zanul Abidin Zubaidah , Mohd Salleh Nosizana
Published: August 2023

This study aimed to provide a comprehensive review of various recent methods that can be used to assess the fit and accuracy of additive-manufactured removable partial dentures (RPDs), focusing on 3D-printed RPDs. An electronic search of the English language literature from January 2000 to February 2022 was performed using four databases: Medline/PubMed, Scopus, Web of Science, and EBSCOhost, using relevant keywords. The parameters of interest were extracted and tabulated. Of 936 retrieved studies, 26 studies were included. Most of the studies were laboratory studies, conducted between 2011 and 2022, did not include control group, used stone cast model as reference, used direct 3D printing method, and polished the final RPD framework. Methods of assessment can be divided into two categories: 1) qualitative assessment which is based mainly on visual inspection or tactile sense, and 2) quantitative assessment which includes optical assessment (with or without a registration material) and computerized assessment based on surface-matching software programs. In conclusion, computerized assessment using different surface matching software provides more accurate and precise quantitative assessment of denture fit and allows researcher and practitioner to detect minute dimensional changes that cannot be detected visually.
Geometric recurrence of inhomogeneous Gaussian autoregression process
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Moskanova Olga
Published: August 2023

In this paper we study Gaussian autoregression model of the form X_{n+1} = α_{n+1} X_n + W_{n+1}. It has time-inhomogeneous centered normal increments W_n and control ratios α_n. We obtained upper bounds for expectation of exponential return time to the compact [−c; c] and for expectation of the function of compressing ratios and the mentioned moment.
FİRMALARIN FİNANSAL BAŞARISIZLIKLARININ TAHMİNİNDE ÇEŞİTLİ YÖNTEMLERİN KARŞILAŞTIRILMASI: BIST ÖRNEĞİ
Authors: KURTARAN ÇELİK Melike , KURTARAN Ahmet
Published: August 2023

Bu çalışmanın amacı firmaların finansal başarısızlıklarını önceden tahmin edebilmek için, bugüne kadar geliştirilen çeşitli tahmin modellerinden literatürde oldukça yaygın kullanılan Diskriminant Analizi ve Yapay Sinir Ağları modellerinin tahmin güçlerini karşılaştırarak en iyi tahmin modelinin oluşturulmasıdır. Çalışmada BIST’te işlem gören 355 firmaya ait finansal oranlar kullanılarak firmaların finansal başarısızlığa düşme olasılıkları 1, 2 ve 3 yıl öncesinden tahmin edilmeye çalışılmıştır. Bu amaçla finansal başarısızlıktan önceki her bir yıl için diskriminant analizine ve yapay sinir ağlarına göre ayrı ayrı tahmin modelleri oluşturulmuştur. Çalışma sonucunda firmaların finansal başarısızlığa düşme olasılıklarını en iyi tahmin eden modellerin bir ve üç yıl öncesine göre diskriminant analizi oranlarıyla oluşturulan yapay sinir ağı modeli; İki yıl öncesine bakıldığında tüm finansal oranlarla oluşturulan yapay sinir ağı modeli olduğu tespit edilmiştir.
Rationale and Design for Time Restricted Eating (TRE) and Mediterranean Diet TRE During Chemotherapy for Breast Cancer
Authors: Gabel Kelsey
Published: August 2023

Current standard care during treatment for breast cancer encourages enough energy intake to avoid lean mass loss, yet most patients struggle with weight gain during treatment. Time restricted eating (TRE) may garner positive effects on treatment outcomes as well as beneficial effects on glucose regulation and body composition. One potential drawback to TRE is that it does not address deficiencies in diet quality. Like TRE, a Mediterranean Diet (MedDiet) may provide benefits to this patient population. Thus, combining TRE with a MedDiet may have important health implications for breast cancer patients. TRE alone or combined with a MedDiet in breast cancer patients during chemotherapy treatment is limited or not yet investigated. We describe a 12-week pilot trial of 8-hour TRE, 8-hour MedTRE, or Control among 45 females initiating chemotherapy for Stage I-III breast cancer. Aims of the study include, (1) Feasibility and accessibility and (2) preliminary efficacy on treatment related outcomes and (3) preliminary efficacy on glucometabolic and cancer-related biomarkers, body weight, and body composition. The long-term goal of this line of inquiry is to improve quality of life and long-term health outcomes to lead to a fully powered efficacy trial of TRE and MedTRE in this patient population.
The Role of Rural Health Centres in the Detection and Management of Malaria Outbreaks in a Low Transmission Setting of Choma District, Zambia
Authors: lubinda Mukuma , Matoba Japhet , Sing’anga Caison , G. Meleki Emmanuel , Mukosha Rakel , Mudenda Twig , Simubali Limonty , M. Mburu Monicah , Simulundu Edgar , Thuma Phillip , Shiff Clive
Published: August 2023

The Southern Province of Zambia has been afflicted with malaria for many years, but in recent times, with the success of the national malaria control programme, malaria transmission has declined significantly and is now at low ebb. This success has been attributed to the effective use of indoor residual spraying, proper use of insecticide-treated mosquito nets provided to the people, as well as the use of artemisinin combination therapies in all rural health centres (RHCs) to treat clinical malaria cases at health facilities as well as in the communities by trained community health workers (CHWs). Despite this success and in trying to understand the epidemiology and control of malaria in rural areas of sub-Saharan Africa, it has been clear that local elimination is most unlikely due many challenges such as lack of incentives for CHWs who are the first link of the community to the health care system, inability of the officially approved rapid diagnostic tests to detect low level parasitemia in asymptomatic individuals, and anti-malaria stock-outs in RHCs, especially during the rainy season when most areas are unreachable due to impassable roads. This paper discusses the role of RHCs in the detection and management of malaria outbreaks in low transmission settings and the challenges of achieving elimination in Choma District, Southern Province, Zambia. These challenges could adversely impact malaria elimination if they remain unanswered.
Medical Oxygen as a Life-Saving Medicine: A rapid review of the oxygen landscape and innovative efforts in the World Health Organization Eastern Mediterranean Region in Response to COVID-19 and Beyond
Authors: Kodama Chiori , Salem Mohamed , Kuniyoshi Gary , Koya Shaffi , Othman Mostafa , Iwamoto Kazuyo , Abubakar Abdinasir , Brennan Richard
Published: August 2023

Background: Medical oxygen is an essential treatment for life-threatening hypoxemic conditions and is commonly indicated for the clinical management of many leading causes of mortality. Many countries of the World Health Organization (WHO) Eastern Mediterranean Region (EMR) lacked robust medical oxygen systems prior to the COVID-19 (corona virus disease) pandemic and this situation was exacerbated by increased needs, particularly in remote and rural health facilities, resulting in many unfortunate deaths. The aim of this article is to describe the oxygen landscape in the region and the regional initiatives undertaken by countries and WHO. Methodology: We conducted a rapid review to synthesize the available literature on the needs and availability of oxygen and its related resources and the regional initiatives undertaken. We conducted search in PubMed, relevant WHO and World Bank websites, and in general using google to understand the health of conditions that could benefit from the availability of medical oxygen, oxygen related resources including health workforce available for support and usage of medical oxygen, and the initiatives by WHO, countries and partners to improve the situation. We used a snowballing technique and reviewed all available databases for reports, surveys, assessments, and studies related to medical oxygen, besides WHO internal records, assessments, and consultation reports. Results: The data on oxygen availability, supply demand gap, infrastructure facilities, and human resources were sparse. The regional initiatives have led to increase in resources, including human resources and oxygen production infrastructure. The Live Oxygen Platform (LOP), contributed to improved availability of quality data needed for supply-demand assessments. Conclusion: A regional enterprise strategy to promote sustainable, decentralized, and contextualized production, supply, and monitoring of oxygen together with human resource support including training and placement by WHO, partners, and governments contributed to improved availability of oxygen in the region. Additionally, with the LOP, governments, WHO, and partners have access to better data availability for policy decision making and timely resource allocation.
Risk of Acute Kidney Injury Following Mytomicin C Resorption during Hyperthermic Intraperitoneal Chemotherapy
Authors: Witte Piet , Bruins Peter , Boerma Djamila , Kemmel Veronique
Published: August 2023

Background: Surgical cytoreduction and simultaneous hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is a common treatment for peritoneal carcinomatosis. During intraperitoneal chemotherapy, mitomycin C is frequently used. Mitomycin C is known to be nephrotoxic. Little is known about the effect of systemically absorbed mitomycin C on renal function during HIPEC surgery. Methods: In twenty-two patients undergoing cytoreductive surgery and HIPEC for peritoneal carcinomatosis the systemic levels of mitomycin C were measured in plasma. The relation of plasma levels of mitomycin C with duration of surgery and complexity of surgery was evaluated. Furthermore, we evaluated the relation between systemic mitomycin C levels with renal function. Results Two patients of the total of 22 patients developed acute kidney injury. In these patients, preoperative creatinine level increased from (1) 109 μmol/L to maximum 890 μmol/L on the 6th postoperative day after which renal replacement therapy was started and (2) from 67 μmol/L to 213 μmol/L. Whereas maximum plasma levels of mitomycin C in these 2 patients were 145 μg/L and 280 μg/L compared to the levels in the other patients (167 μg/L ±80.8). Peak levels of plasma creatinine were on post operative day 2. None of the other patients needed renal replacement therapy. Eight patients showed significant increase of plasma creatinine levels, i.e. >20% increase from preoperative values. We did not observe a correlation between complexity of surgery, increased absorption of mitomycin C, higher mitomycin C plasma levels and signs of kidney injury. Conclusions: Systemic absorption of mitomycin C during HIPEC surgery is independent to extension of cytoreductive surgery and duration of surgery. In this small study group, we observed an impairment of renal function which may be related to systemic absorption of mitomycin C. Further research is warranted to answer possible association of mitomycin C levels in patients at risk for development of AKI.
Eradication of Antibiotic-Resistant E. coli, S. aureus, K. pneumoniae, S. pneumoniae, A. baumannii, and P. aeruginosa with Chlorine Dioxide In Vitro
Authors: Georgiou George , Kotzé Agnieszka
Published: August 2023

Bacterial Antibiotic Resistance (AMR) is a problem in all regions, with six pathogens accounting for 73.4% of deaths attributable to bacterial AMR, namely Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Klebsiella pneumoniae (K. pneumoniae), Streptococcus pneumoniae (S. pneumoniae), Acinetobacter baumannii (A baumannii), and Psuedomonas aeruginosa (P. aeruginosa). The World Health Organization instigated a Global Action Plan on AMR in 2021, which is still active - healthcare costs for AMR run into many billions of dollars worldwide. A Review on Antimicrobial Resistance commissioned by the British Government argued that AMR could kill 10 million people per year by 2050 and has emerged as one of the greatest public health threats of the 21st century. Just one AMR pathogen, Methicillin-Resistant Staphylococcus aureus (MRSA), caused more than 100,000 deaths worldwide, with the other four pathogens covered in this research causing as many deaths again. This research has focused on studying chlorine dioxide's effectiveness in eradicating five different AMR bacteria in vitro as a novel and effective treatment. This study used different chlorine dioxide concentrations with five antibiotic-resistant bacteria, ranging from 1 – 7 ppm concentrations. Disinfection studies were compared to controls, and the results demonstrated a greater than 95% disinfection with concentrations of 7 ppm. Chlorine dioxide is a size-selective antimicrobial agent that can kill micron-sized organisms rapidly but will not cause actual harm to much larger organisms like animals or humans as it cannot penetrate deeply into their living tissues. It is safe when used in low concentrations for short durations. Clinical trials must be undertaken to gain experience in the best dosages and protocols to eradicate antibiotic-resistant microorganisms from the body.
Analyzing Career Perception and Preparation Behaviors of College of Education Students Using Q-Methodology
Authors:   The Korea Association of Yeolin Education, Choi Ryumi , Kim Eunbin
Published: August 2023

Through the Q methodology, this study attempted to identify types of career perception and behavior of students at College of Education and to analyze the contents and methods of career education according to the characteristics of each type. Thirty-six Q statements were selected that represent the perception and preparation behavior of career were drawn by literature review and interview. The sample consisted of 32 college of education students. They were asked to rank-order Q statements on the 11 point continuum first, and then to explain the reasons why they made their choices. The result of this study was classified into five types, based on the interpretation of the most agreed and disagreed statements: 1) burden of examination of education 2) thorough career behavior 3) career immaturity 4) exploring alternative career 5) deferral of career preparation. Based on the results of this study, suggestions that include guidance plans of education and policy for college of education are discussed.