bluuebunny/crossref_metadata_2025 huggingface dataset:
Microvibration Control of Hybrid Platform for High-Tech Equipment in Buildings Using Brain Emotional Learning-Based Intelligent Controller
Authors: Tappiti Chandrasekhara , Lin Tzu-Kang
Published: October 2023

In the semiconductor industry, the vulnerability of high-tech facilities installed on platforms to ground excitations induced by nearby traffic is significantly pronounced, primarily due to their small-scale dimensions. Consequently, it is imperative to design a smart control technique by effectively utilizing model-free controllers. Recently, adaptive intelligent control algorithms have emerged as a viable alternative to conventional model-based control algorithms. To address this issue, this study meticulously designed a hybrid platform using the adaptive intelligent controller known as the brain emotional learning-based intelligent controller, along with a Sugano fuzzy inference system to effectively optimize the controller’s learning parameters. These learning and intelligent-based algorithms offer notable advantages, including the ability to handle nonlinearity, uncertainty, and training capabilities within the control systems. To assess the effectiveness of the proposed controller in mitigating vibrations induced by traffic on high-tech facilities, a three degree-of-freedom structure is employed along with the hybrid platform. Finally, the performance of the hybrid platform in terms of microvibration control levels is meticulously validated using the Bolt Beranek Newman vibration criteria. Simulation results unequivocally demonstrate that the proposed controller outperforms both an uncontrolled system and a traditional linear quadratic regulator controller in terms of reducing the traffic-induced response of the hybrid platform and second floor, respectively. Through the integration of learning and intelligent-based controllers, the velocity levels of both the hybrid platform and the second floor are reduced to approximately 49.02% and remain well within the acceptable standard criteria curves.
A New Cardiovascular Mock Loop Driven by Novel Active Capacitance in Normal and Abnormal Conditions
Authors: Iscan Mehmet , Yesildirek Aydin
Published: October 2023

The hybrid mock circulatory loop (hMCL) serves as a crucial hemodynamic simulation tool, offering exceptional flexibility, controllability, and reproducibility for investigating the mechanisms underlying cardiovascular diseases (CVD) in a controlled environment, circumventing the limitations of live organism studies. This paper introduces a novel design and control strategy for hMCL, introducing a novel left ventricle volume–elastance (LVVE) equation that unifies the autoregulation of the Frank–Starling mechanism (FSM) with left ventricle contractility (LVC). LVVE establishes a dynamic link between left ventricular volume (LVV) and LVC, inherently satisfying the regulatory relationship between left ventricular pressure (LVP) and LVV through a mathematical equation. For the first time, LVVE integration significantly enhances the physiological relevance of hMCL by faithfully replicating FSM responses across diverse conditions, including aortic stenosis (AS), variations in systemic vascular resistance (SVR), and heart rate (HR) variations. Furthermore, this study introduces the stability proofs for the discrete closed-loop hMCL, enabling real-time proportional valve control through discrete feedback linearization—an innovative departure from conventional methods. Notably, FSM emulation is achieved by tracking reference maximum and minimum LVV values, eliminating the reliance on predefined functions or existing data, such as the maximum LV elastance value. Rigorous experimental validation, encompassing numerical simulations and comparative analyses with prior research, attests to the precision and efficacy of the proposed hMCL in faithfully replicating both normal and abnormal CV conditions. Significantly, the hMCL demonstrates that increasing HR enhances LVC while maintaining physiological pressures; however, this increase in LVC corresponds with a decrease in LVV, in alignment with human data and FSM principles. Crucially, the coupling mechanism between the FSM and LVC yields results of enhanced physiological fidelity, significantly advancing the hMCL’s utility in physiological research. Moreover, the hMCL’s capacity to simulate critical cardiovascular scenarios, including AS, SVR fluctuations, and HR variations, underscores its versatility and substantial potential for investigating complex CV dynamics.
Bachmann’s Bundle Modification in Addition to Circumferential Pulmonary Vein Isolation for Atrial Fibrillation: A Novel Ablation Strategy
Authors: Sun Jiaqi , Chen Sanbao , Liang Ming , Zhang Qi , Zhang Ping , Sun Mingyu , Ding Jian , Jin Zhiqing , Han Yaling , Wang Zulu
Published: October 2023

Background. Bachmann’s bundle (BB) is the main pathway of interatrial connection that could be involved in the development of atrial fibrillation (AF). Based on this hypothesis, we raised a novel ablation strategy, BB modification in addition to circumferential pulmonary vein isolation (CPVI-BB) in patients with AF. Methods. A retrospective cohort of patients with AF who underwent CPVI-BB or CPVI alone from March 2018 to July 2021 was enrolled in our study. Propensity score matching was performed in patients with paroxysmal AF and persistent AF, respectively, to reduce the risk of selection bias between the treatment strategies (CPVI-BB or CPVI alone). The primary endpoint was overall freedom from atrial arrhythmia recurrence through 12 months of follow-up. Results. Our propensity score-matched cohort included 82 patients with paroxysmal AF (CPVI group: n = 41; CPVI-BB group: n = 41) and 168 patients with persistent AF (CPVI group: n = 84; CPVI-BB group: n = 84). Among patients with persistent AF, one-year freedom from atrial arrhythmia recurrence rate was 83.3% in the CPVI-BB group and 70.2% in the CPVI group (log-rank

P

 = 0.047). Among patients with paroxysmal AF, no significant difference was found in the primary endpoint between two groups (85.4% in the CPVI-BB group vs. 80.5% in the CPVI group; log-rank

P

 = 0.581). In addition, procedure-related complications and recurrence of atrial tachycardia or atrial flutter were similar between the two treatment groups, regardless of the type of AF. Conclusions. BB modification in addition to CPVI is an effective approach in increasing the maintenance of sinus rhythm in patients with persistent AF, while it does not improve the clinical outcomes of radiofrequency catheter ablation in patients with paroxysmal AF.
Splitting Mealtime Insulin Doses for Mixed Fat and Protein Meals in Children and Adolescents with Type 1 Diabetes Using Multiple Daily Injection Regimen: A Randomized Cross-Over Trial
Authors: Hegab Ahmed M. , Hasaballah Susana E. , Mohamed Montaser M.
Published: October 2023

Aims. Assessment of the glycemic outcomes of increasing and splitting mealtime insulin doses for mixed fat and protein meals in pediatric patients with type 1 diabetes mellitus (T1DM) using multiple daily injection regimen and comparing the effects of regular insulin and fast-acting insulin on glycemic outcomes following those meals. Methods. This single-center, randomized, cross-over trial included 43 children and adolescents with T1DM randomly assigned to receive three interventional insulin doses for lunch meals over 3 consecutive days; Intervention A (100% insulin-to-carbohydrate ratio (ICR) dose given as premeal insulin lispro with an additional insulin sensitivity factor-calculated correction dose after 3 hr), Intervention B (130% ICR dose split into 60% premeal insulin lispro and 40% postmeal insulin lispro after 30 min), and Intervention C (130% ICR dose split into 60% premeal insulin lispro and 40% postmeal regular insulin after 30 min). The test meal consisted of two slices of pizza (weight: 150 g, carbohydrates: 40 g, fat: 15 g, protein: 20 g, and calories: 380 kcal). Postprandial blood glucose levels were monitored for 6 hr. Results. There were no significant differences in postprandial blood glucose excursions following the three interventions. However, Intervention C had a significantly lower late (3–6 hr) blood glucose area under the curve (

p
=
0.01

). Postprandial hypoglycemia developed in 12 participants (27.9%) following Interventions A and B and in 17 participants (39.5%) following Intervention C (

p
=
0.32

). Conclusions. Using regular insulin as a postmeal portion of increased and split insulin doses provided better late postprandial glycemic outcomes following mixed fat and protein meals. However, the amount of additional insulin used needs optimization to reduce the frequency of postprandial hypoglycemia. This trial is registered with NCT04783376.
HSF1 Inhibits Antitumor Immune Activity in Breast Cancer by Suppressing CCL5 to Block CD8+ T-cell Recruitment
Authors: Jacobs Curteisha , Shah Sakhi , Lu Wen-Cheng , Ray Haimanti , Wang John , Hockaden Natasha , Sandusky George , Nephew Kenneth P. , Lu Xin , Cao Sha , Carpenter Richard L.
Published: October 2023

Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes cancer cell malignancy. To provide a better understanding of the biological processes regulated by HSF1, here we developed an HSF1 activity signature (HAS) and found that it was negatively associated with antitumor immune cells in breast tumors. Knockdown of HSF1 decreased breast tumor size and caused an influx of several antitumor immune cells, most notably CD8+ T cells. Depletion of CD8+ T cells rescued the reduction in growth of HSF1-deficient tumors, suggesting HSF1 prevents CD8+ T-cell influx to avoid immune-mediated tumor killing. HSF1 suppressed expression of CCL5, a chemokine for CD8+ T cells, and upregulation of CCL5 upon HSF1 loss significantly contributed to the recruitment of CD8+ T cells. These findings indicate that HSF1 suppresses antitumor immune activity by reducing CCL5 to limit CD8+ T-cell homing to breast tumors and prevent immune-mediated destruction, which has implications for the lack of success of immune modulatory therapies in breast cancer.

Significance:

The stress-responsive transcription factor HSF1 reduces CD8+ T-cell infiltration in breast tumors to prevent immune-mediated killing, indicating that cellular stress responses affect tumor-immune interactions and that targeting HSF1 could improve immunotherapies.
PHF6-altered T-ALL Harbor Epigenetic Repressive Switch at Bivalent Promoters and Respond to 5-Azacitidine and Venetoclax
Authors: Pinton Antoine , Courtois Lucien , Doublet Charlotte , Cabannes-Hamy Aurélie , Andrieu Guillaume , Smith Charlotte , Balducci Estelle , Cieslak Agata , Touzart Aurore , Simonin Mathieu , Lhéritier Véronique , Huguet Françoise , Balsat Marie , Dombret Hervé , Rousselot Philippe , Spicuglia Salvatore , Macintyre Elizabeth , Boissel Nicolas , Asnafi Vahid
Published: October 2023

Purpose:

To assess the impact of PHF6 alterations on clinical outcome and therapeutical actionability in T-cell acute lymphoblastic leukemia (T-ALL).

Experimental Design:

We described PHF6 alterations in an adult cohort of T-ALL from the French trial Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)-2003/2005 and retrospectively analyzed clinical outcomes between PHF6-altered (PHF6ALT) and wild-type patients. We also used EPIC and chromatin immunoprecipitation sequencing data of patient samples to analyze the epigenetic landscape of PHF6ALT T-ALLs. We consecutively evaluated 5-azacitidine efficacy, alone or combined with venetoclax, in PHF6ALT T-ALL.

Results:

We show that PHF6 alterations account for 47% of cases in our cohort and demonstrate that PHF6ALT T-ALL presented significantly better clinical outcomes. Integrative analysis of DNA methylation and histone marks shows that PHF6ALT are characterized by DNA hypermethylation and H3K27me3 loss at promoters physiologically bivalent in thymocytes. Using patient-derived xenografts, we show that PHF6ALT T-ALL respond to the 5-azacytidine alone. Finally, synergism with the BCL2-inhibitor venetoclax was demonstrated in refractory/relapsing (R/R) PHF6ALT T-ALL using fresh samples. Importantly, we report three cases of R/R PHF6ALT patients who were successfully treated with this combination.

Conclusions:

Overall, our study supports the use of PHF6 alterations as a biomarker of sensitivity to 5-azacytidine and venetoclax combination in R/R T-ALL.
Sensitivität und Spezifität verschiedener prognostischer Systeme zur Lenkung der Überwachung auf Metastasen beim Aderhautmelanom
Authors: Seibel Ira
Published: October 2023

Uveal melanoma (UM) metastasises in ∼50% of patients, most frequently to the liver. Surveillance imaging can provide early detection of hepatic metastases; however, guidance regarding UM patient risk stratification for surveillance is unclear. This study compared sensitivity and specificity of four current prognostic systems, when used for risk stratification for surveillance, on patients treated at the Liverpool Ocular Oncology Centre (LOOC) between 2007–2016 (n = 1047). It found that the Liverpool Uveal Melanoma Prognosticator Online III (LUMPOIII) or Liverpool Parsimonious Model (LPM) offered greater specificity at equal levels of sensitivity than the American Joint Committee on Cancer (AJCC) system or monosomy 3 alone, and suggests guidance to achieve 95% sensitivity and 51% specificity (i.e., how to detect the same number of patients with metastases, while reducing the number of negative scans). For example, 180 scans could be safely avoided over 5 years in 200 patients using the most specific approach. LUMPOIII also offered high sensitivity and improved specificity over the AJCC in the absence of genetic information, making the result relevant to centres that do not perform genetic testing, or where such testing is inappropriate or fails. This study provides valuable information for clinical guidelines for risk stratification for surveillance in UM.
Trichoscopy of Discoid Lupus Erythematosus in the Black Scalp: A Literature Review
Authors: Lemos Thayane Batista , Cortez de Almeida Rita Fernanda , Frattini Sidney , Starace Michela , Melo Daniel Fernandes
Published: October 2023

Discoid lupus erythematosus (DLE) is the most common type of chronic cutaneous lupus erythematosus. It is more frequent in adult women, particularly black race. Scalp DLE has an earlier onset and a more severe clinical course in black patients compared to Caucasians. Nevertheless, studies on this population remain scarce. The aim of this study was to review the literature and summarize the most frequent trichoscopic findings of scalp DLE among patients with a higher phototype. The main trichoscopic findings of DLE on black scalp are interruption of the honeycomb pattern, reduction, or absence of pinpoint white dots, keratotic follicular plugs and peripilar casts, blue-gray dots in a speckled pattern, and large tortuous arboriform vessels. Knowledge of these and other changes enables an early diagnosis of these individuals, preventing cicatricial sequelae and reducing its impact on quality of life.
Subkonjunktivale okuläre Argyrose nach Behandlung des Aderhautmelanoms mit Ruthenium-106-Brachytherapie
Authors: Khasati Aya , Thaung Caroline , Mudhar Hardeep S. , Wagner Bart , Goggin Patricia , Stoker Ian , Sagoo Mandeep S. , Damato Bertil , Quhill Hibba
Published: October 2023

Einleitung: Die Brachytherapie mit Ruthenium-106 (Ru-106) ist eine der am weitesten verbreiteten augenschonenden Behandlungsmethoden des Aderhautmelanoms. Diese Patienten benötigen eine langfristige Überwachung des behandelten Tumorrestes, um sicherzustellen, dass es nicht zu einem lokalen Rezidiv kommt. Neue oder fortschreitende pigmentierte Läsionen in behandelten Augen werden oft als verdächtig angesehen, insbesondere wenn eine extrasklerale Ausbreitung befürchtet wird. Fallvorstellungen: Wir stellen 2 Fälle von posteriorem Aderhautmelanom vor, die 5 bzw. 10 Jahre zuvor mit Ru-106 behandelt worden waren. In beiden Fällen entwickelten sich dunkle/schwarze subkonjunktivale Läsionen auf der vorderen Augenoberfläche im Quadranten der Bindehautperitomie während der Behandlung mit Ru-106. Beide wiesen ähnliche histopathologische Befunde auf: schwarzes, anorganisches, partikuläres Fremdmaterial unterschiedlicher Konfluenz, das sich auf Elastin- und Kollagenfasern ablagerte. Die energiedispersive Röntgenmikroanalyse bestätigte das Vorhandensein von Silber im Material.
Ultrasonographic aspects of the gallbladder mucocele in 30 dogs: retrospective study
Authors: Deusdado Fernanda de Carlo , Lorigados Carla Aparecida Batista , Pantano Marianna , Hayashi Ayne Murata , Calderon Fabio
Published: October 2023

Gallbladder mucocele is characterized by hyperplasia of the gallbladder epithelium, increased mucus production, accumulation, and densification of the bile content, which can lead to biliary obstruction, necrosis, and rupture of the gallbladder wall. Its finding may be accidental or related to symptoms. A retrospective study (2016-2019) was carried out based on abdominal ultrasound examinations in dogs, correlating aspects of the gallbladder and biliary system in the mucocele with existing comorbidities. Thirty dogs diagnosed with biliary mucocele were evaluated, of which 46.66% had the disease at an early stage, and 53.33% showed a more advanced stage. Of these, 66.66% were related to endocrinopathies and hyperadrenocorticism. Signs of extrahepatic bile duct obstruction and biliary peritonitis were observed in two animals. Due to their potential risk of complications, follow-up ultrasound assessments are indicated in cases that opt for clinical treatment, not excluding the need for surgical intervention.
Association of S(+) ketamine, dexmedetomidine and butorphanol for chemical restraint in scarlet macaws (Ara macao)
Authors: Caldas Suzana Maria da Silva , Gering Ana Paula , Santos Mara Régia Teixeira , Mendonça Cinthian Cássia , Carreira Adriana Genelhú , Armani Daniela Jorge Coutinho , Benarrós Marina Sette Camara , Diniz Rafael Romeu Ferreira
Published: October 2023

The present study aimed at assessing the effects of combining 20 mg/kg S(+) ketamine with 25 μg/kg dexmedetomidine and 0.4 mg/kg butorphanol on the physiological parameters and anesthetic recovery time and score of eight captive scarlet macaw (Ara macao) specimens. These specimens were captured at the Marabá Zoobotanic Foundation (Fundação Zoobotânica de Marabá), Pará, using butterfly and mist nets, and subsequently subjected to the proposed protocol. The following physiological parameters were evaluated: heart rate (HR), respiratory rate (RR), saturation of peripheral oxygen (SpO2), body temperature (BT), and non-invasive blood pressure 5 min after drug administration (M0) and every 10 min thereafter (M1‒M5), with a total of 55 min of analysis of anesthetic effects. Glycemia was measured 5 min after drug administration and every 30 min thereafter. Anesthetic induction and recovery times were also determined. Among the parameters evaluated in this study, both HR and BT significantly decreased throughout the anesthetic period, with the lowest levels at 55 min after drug administration (M5). In contrast, RR did not significantly differ, and all animals remained stable, maintaining an RR close to a mean of 20 ± 8 cpm. Throughout the anesthetic period, SpO2 was 92 ± 5%, with no significant difference. The birds remained under spontaneous ventilation and without oxygen supplementation. Systolic, diastolic, and mean blood pressures remained stable, with no significant differences in any of these measurements. At M0 and M3, the glycemia decreased slightly, albeit with no significant difference justifying an adverse effect or even hypoglycemia. The anesthetic induction time, from M0 to decubitus, was 2.4 ± 0.7 min. The anesthetic recovery time, from M0 to effortless bipedal position and adequate phalangeal flexion, was 99.3 ± 32.4 min. The sedation was assessed as intense, and the anesthetic recovery was rated excellent in 62.5% and good in 37.5% of the animals.
A crítica que nos faz outros
Authors: Pino Claudia Amigo , Vidal Paloma
Published: October 2023

Editorial do dossiê "Travessias da crítica da América Latina".
A poeta invisível: a posição do sujeito em La Bandera de Chile, de Elvira Hernández, a partir da morte do autor barthesiana
Authors: Zelic Helena
Published: October 2023

O artigo propõe uma aproximação entre a ética e os procedimentos de escrita da poeta chilena Elvira Hernández (1951-) e a perspectiva do crítico francês Roland Barthes (1915-1980) sobre a posição do autor, descrita no ensaio “A morte do autor”, publicado na obra O rumor da língua. Para isso, foram analisados três poemas da obra La bandera de Chile (1991) em relação à construção do sujeito na obra. Um diálogo entre Barthes e Hernández é elaborado, ancorado em entrevistas e textos críticos da poeta, nos quais ela defende a prioridade da palavra em detrimento do autor. O artigo também traça um breve panorama da circulação de Barthes no Chile ditatorial, mapeando relações entre poetas, professores e críticos, bem como textos em que mencionam o pensamento barthesiano, e propondo uma leitura sobre suas consequências estético-políticas no contexto autoritário e censório do período.
Duchamp na América Latina, outra vez: Um percurso por Bolaño, Antelo e Bellatin
Authors: Lima Natalie
Published: October 2023

Em Maria com Marcel – Duchamp nos trópicos (2010), Raúl Antelo realiza o que chama de “política do anacronismo”: articula ideias, personagens e procedimentos que transitam entre continentes no início do século XX; faz emergir um heterogêneo arquivo ficcional latino-americano em que os trabalhos de Duchamp funcionam como motores críticos para pensar a arte, a política e a literatura na América Latina. Juntamente com Antelo, traz-se dois escritores contemporâneos que operam procedimentos e questões duchampianas de maneiras distintas: Roberto Bolaño e sua apropriação do Ready-made infeliz, em 2666, e Mario Bellatin na ficção El gran vidrio – Trés autobiografias. Ao articularem os jogos de Duchamp em torno do (in)visível, ambos apontam para o revolucionário em sua arte – uma operação que não é retiniana, plástica, mas crítica e filosófica; operação que faz da crítica uma criação. Nesse gesto, ele mesmo crítico, conferem historicidade às invenções do artista francês quando vistas desde a América Latina contemporânea, bem como às suas próprias ficções.
Autoria, Autoridade: Questões sobre a escrita de mulheres
Authors: Lousa Pilar Lago e , Brito Tarsilla Couto de
Published: October 2023

Autoria, autoridade, autora, feminino, poetisa, são apenas alguns dos vocábulos insuficientes para o desejo de literatura de escritoras de todos os tempos. A língua, esse organismo vivo, urge ser modificada para dar conta da escrita de mulheres ao sul global. Aqui, onde os construtos eurocentrados não alcançam a diversidade de existências, parece pouco aceitar os prêmios de consolação de um cânone sisudo, excludente e branco-hetero-cis-patriarcal. Então se o texto delas pede uma postura diferente da teoria, um empenho do corpo da crítica que vislumbra o estranhamento, este artigo procura escavar algumas concepções a respeito do tema “autoria” para desfazer, desaprender, desrespeitar e a partir daí criar epistemologias à luz de teóricas como María Lugones (2020), Ochy Curiel (2020) e Conceição Evaristo (2019) para compreender a escrita de mulheres. Atendendo ao chamado de Glória Anzaldúa, é preciso que essas mulheres escrevam, em qualquer lugar e tempo, não dá para esperar as condições perfeitas chegarem. É preciso ousar existir. Ao final deste estudo, deixamos que algumas de nossas escritoras se digam em processos de escuta e aprendizado que não se encerram neste artigo.
"Torto Arado" entre o sinuoso e o retilíneo: elogios e interdições
Authors: Souza Yuri Moura Lima Amaral de
Published: October 2023

Este artigo tem como objetivo contribuir com a discussão acerca de um dos maiores fenômenos literários brasileiros do século XXI: o romance Torto Arado. A discussão acerca da qualidade da obra literária, no entanto, parece estar sendo pautada pela necessidade e pela pertinência temática. Os elogios à obra, pouco alicerçados na análise da construção literária, parecem ter criado um ambiente que interdita o debate acerca dos avanços e das fragilidades da elaboração poética da narrativa. Nesse sentido, abordamos alguns momentos da recepção do romance e fazemos uma proposta de leitura realista de algumas passagens do texto para tecer algumas considerações sobre determinados aspectos que podem ser considerados problemáticos ou inconsistentes na construção das três narradoras da referida obra.
UMA LEITURA DA PROPAGANDA PRODUZIDA PELO IPES (1962-1964) A PARTIR DAS BASES BIOLÓGICAS E PSICOSSOCIAIS DO COMPORTAMENTO HUMANO
Authors: Kaufmann Celia Regina Justo , Batista Leandro Leonardo
Published: October 2023

Um dos acontecimentos mais marcantes da história do Brasil, refere-se ao Golpe de 1964, o qual subverteu a ordem existente e deu início a um regime ditatorial. Partindo do pressuposto de que outros métodos de análise podem ser incorporados às pesquisas em História, o presente trabalho tem por objetivo contribuir com conceitos da Biologia, da Psicologia e da Comunicação Social, para analisar e compreender como a opinião pública poderia ter sido moldada entre 1962 e 1964. A partir de métodos comparativos e dedutivos de análise de uma vasta literatura específica, verificou-se a eficácia que uma campanha multifacetada teve em recrutar efeitos psicológicos e biológicos, moldando a opinião pública e levando à derrocada de João Goulart.
A REPRESENTAÇÃO SOCIAL DA MÃE IDOSA NA PUBLICIDADE BRASILEIRA DO DIA DAS MÃES: COMUNICAÇÃO CONSOLATÓRIA ENTRE O ESTILO AGELESS E AGEFULL DE ENVELHECER
Authors: Sampaio César Augusto , Gonzales Lucilene dos Santos
Published: October 2023

A amostra da representação social da mãe idosa na publicidade brasileira compreende as publicidades do Dia das Mães de 2021. De caráter quanti-qualitativo, o objetivo foi saber se as mensagens mercadológicas validaram estereótipos e preconceitos de uma imagem sempre jovem e em boa forma da mulher, ou se questionavam ideologias e relações de poder para valorizar a diversidade do gênero feminino, a partir dos pilares de empoderamento do femvertising. Foram coletados anúncios em revistas impressas e digitais, mídias sociais e numa emissora de TV aberta. Prevaleceu a imagem da mãe jovem e de meia-idade, com uma retórica consolatória em detrimento daquela comunicação de acréscimo nutritivo que quebra valores e padrões do establishment social vigente. Mas notou-se também uma tendência na direção de um estilo agefull de envelhecer, que procura se dissociar da conotação mercadológica que teria tomado conta da expressão ageless.
A VIOLÊNCIA INVISÍVEL NA INTERNET: O QUE ESCAPA AO RADAR DO JORNALISMO TRADICIONAL
Authors: Ramos Daniela Osvald , Vilicic Filipe
Published: October 2023

A partir da identificação de Abdin (2021) dos elementos que compõem a internet tida como situada “abaixo do radar” e das distinções entre redes invisível e visível de Bergman (2001), procura-se caracterizar e problematizar a atuação de jornalistas brasileiros em espaços obscuros do online. Como evidências, selecionamos reportagens publicadas entre 2016 e 2019, principalmente na revista e no site da Veja. A partir de pressupostos, observamos preocupantes limites técnicos e metodológicos que comprometem as operações do jornalismo. Para vencer essas barreiras, cujos efeitos são limitantes para o papel noticioso e informativo da profissão, propõe-se o prolongamento das pesquisas com revisões de métodos e aplicação de formas alternativas de apuração.
A UNIÃO DA GUCCI COM O CAMP: O ACIONAMENTO DO PASSADO PARA FALARMOS DO PRESENTE
Authors: Abib Tamiris
Published: October 2023

O campo da moda, parte visível de uma cultura e identidade do indivíduo, produz e divulga valores próprios de seu tempo e de seus consumidores. Ao consumir, pensamos, escolhemos e reelaboramos nosso sentido social. Neste artigo, analisaremos a comunicação da marca Gucci e como sua união com o camp, baseadas em memórias do passado, tornam-se condizentes com os valores atuais de uma sociedade, por meio de rituais de posse: nos quais o consumidor transfere significados dos bens para suas vidas.
APP em topos de morro em dois maciços cristalinos de Florianópolis/SC: aplicação para diferentes modelados de relevo e segundo critérios de delimitação do Antigo e do Novo Código Florestal
Authors: Bernardes Marina Pinho , Luiz Edna Lindaura
Published: October 2023

As Áreas de Preservação Permanente (APP) em topos de morros sofreram alterações nos seus critérios de aplicação no Novo Código Florestal (NCF), especialmente em relação ao que é preconizado na Resolução Conama 303/2002. Além disso, o NCF desconsidera que as elevações brasileiras possuam diferentes modelados de relevo, de acordo com sua estrutura geológica e processos geomorfológicos atuantes em cada região. Os objetivos deste artigo são analisar a aplicação desta tipologia de APPs em dois maciços cristalinos com modelado de dissecação em Florianópolis/SC e verificar possíveis mudanças no grau de proteção em relação aos critérios das normativas citadas. Os resultados revelaram que em uma área de geologia relativamente homogênea, os aspectos de relevo são diferentes e condicionam a delimitação das APPs. Também foi observado que com os critérios do NCF houve redução de 100% das APPs em topo de morro em relação aqueles do Antigo Código e Resolução Conama 303/2002.
Territórios da natureza: apropriação e extinção no Brasil
Authors: Suertegaray Dirce Maria Antunes
Published: October 2023

A geografia, desde sua origem como campo do conhecimento e, mesmo antes, desde a antigüidade, sempre se preocupou em compreender o espaço enquanto morada do homem (e das mulheres) no planeta Terra. Constitui, portanto, uma ciência cujo conceito balizador de seus estudos é o espaço geográfico. Entende-se por espaço geográfico a materialização das práticas humanas sobre a superfície da terra (no sentido amplo). Trata-se de refletir sobre a produção do espaço na sua relação complexa e contraditória entre as práticas humanas que decorrem de seu modo de produzir, de sua forma de se organizar socialmente e da construção de sua cultura. Pensado dessa forma, o espaço geográfico constitui uma totalidade, impossível de ser contemplado analiticamente. Por essa razão, propomos que este possa ser lido a partir de diferentes conceitos, expressão diferenciada da leitura geográfica sobre o espaço geográfico.
O papel da geografia na valorização da ciência
Authors: Vilela Fernando Nadal Junqueira
Published: October 2023

O papel da geografia na valorização da ciência.
A divulgação científica do canal Nerdologia no YouTube
Authors: Reale Manuella Vieira
Published: October 2023

Este artigo compreenderá as diferentes estratégias enunciativas e os regimes de sentido e de interação dos vídeos do canal Nerdologia. O objeto de estudo é composto pelo canal Nerdologia no YouTube. A análise da enunciação do texto sincrético segue a corrente teórica da sociossemiótica, com base em Greimas (ano). Para a noção de divulgação científica, Bueno (ano), Vogt (ano) e Lewestein (ano). Em diferentes regimes de sentido e de interação Landowski (ano), verifica-se como o Nerdologia lança mão de narrativas estratégicas para impelir a construção de sentido conjuntamente com o destinatário a fim de acentuar o gosto pela ciência enquanto objeto de valor.
MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy
Authors: Shridhar Puneeth , Glennon Michael S. , Pal Soumojit , Waldron Christina J. , Chetkof Ethan J. , Basak Payel , Clavere Nicolas G. , Banerjee Dipanjan , Gingras Sebastien , Becker Jason R.
Published: October 2023

BACKGROUND:

Microvasculature dysfunction is a common finding in pathologic remodeling of the heart and is thought to play an important role in the pathogenesis of hypertrophic cardiomyopathy (HCM), a disease caused by sarcomere gene mutations. We hypothesized that microvascular dysfunction in HCM was secondary to abnormal microvascular growth and could occur independent of ventricular hypertrophy.

METHODS:

We used multimodality imaging methods to track the temporality of microvascular dysfunction in HCM mouse models harboring mutations in the sarcomere genes
Mybpc3
(cardiac myosin binding protein C3) or
Myh6
(myosin heavy chain 6). We performed complementary molecular methods to assess protein quantity, interactions, and post-translational modifications to identify mechanisms regulating this response. We manipulated select molecular pathways in vivo using both genetic and pharmacological methods to validate these mechanisms.

RESULTS:

We found that microvascular dysfunction in our HCM models occurred secondary to reduced myocardial capillary growth during the early postnatal time period and could occur before the onset of myocardial hypertrophy. We discovered that the E3 ubiquitin protein ligase MDM2 (murine double minute 2) dynamically regulates the protein stability of both HIF1α (hypoxia-inducible factor 1 alpha) and HIF2α (hypoxia-inducible factor 2 alpha)/EPAS1 (endothelial PAS domain protein 1) through canonical and noncanonical mechanisms. The resulting HIF imbalance leads to reduced proangiogenic gene expression during a key period of myocardial capillary growth. Reducing MDM2 protein levels by genetic or pharmacological methods normalized HIF protein levels and prevented the development of microvascular dysfunction in both HCM models.

CONCLUSIONS:

Our results show that sarcomere mutations induce cardiomyocyte MDM2 signaling during the earliest stages of disease, and this leads to long-term changes in the myocardial microenvironment.
Upregulated Cytoskeletal Proteins Promote Pathological Angiogenesis in Moyamoya Disease
Authors: He Shihao , Zhang Junze , Liu Ziqi , Wang Yanru , Hao Xiaokuan , Wang Xilong , Zhou Zhenyu , Ye Xun , Zhao Yahui , Zhao Yuanli , Wang Rong
Published: October 2023

BACKGROUND:

Moyamoya disease (MMD) is a rare progressive vascular disease that leads to intracranial internal carotid artery stenosis and eventual occlusion. However, its pathogenesis remains unclear. The purpose of this study is to explore the role of abnormally expressed proteins in the pathogenesis of MMD.

METHODS:

Data-independent acquisition mass spectrometry identifies the differentially expressed proteins in MMD serum by detecting the serum from 60 patients with MMD and 20 health controls. The differentially expressed proteins were validated using enzyme linked immunosorbent assays. Immunofluorescence for superficial temporal artery and middle cerebral artery specimens was used to explore the morphological changes of vascular wall in MMD. In vitro experiments were used to explore the changes and mechanisms of differentially expressed proteins on endothelial cells.

RESULTS:

Proteomic analysis showed that a total of 14 726 peptides and 1555 proteins were quantified by mass spectrometry data. FLNA (filamin A) and ZYX (zyxin) proteins were significantly higher in MMD serum compared with those in health controls (Log
2
FC >2.9 and >2.8, respectively). Immunofluorescence revealed an intimal hyperplasia in superficial temporal artery and middle cerebral artery specimens of MMD. FLNA and ZYX proteins increased the proportion of endothelial cells in S phase and promoted their proliferation, angiogenesis, and cytoskeleton enlargement. Mechanistic studies revealed that AKT (serine/threonine kinase)/GSK-3β (glycogen synthase kinase 3β)/β-catenin signaling pathway plays a major role in these FLNA- and ZYX-induced changes in endothelial cells.

CONCLUSIONS:

This study provides proteomic data on a large sample size of MMD. The differential expression of FLNA and ZYX in patient with MMD and following in vitro experiments suggest that these upregulated proteins are related to the pathology of cerebrovascular intimal hyperplasia in MMD and are involved in MMD pathogenesis, with diagnostic and therapeutic ramifications.
Probabilistic models and contingency tables for studying potential species interactions between two intertidal decapods in the north of Chile (Cifuncho, 25°S, Antofagasta region, Chile)
Authors: De los Ríos-Escalante Patricio R. , Wilson Rodolfo , Ghory Farhana S.
Published: October 2023

The northern Chilean coast is characterized by its high productivity and diversity due to the presence of the cold, nutrient-rich water of the Humboldt Current. In this scenario, the rocky shore provides many microhabitats for invertebrates such as crustaceans. The aim of the present study was to analyse potential species interactions using probabilistic models and contingency tables. In this particular case we analysed the potential interactions between two sympatric intertidal decapods, Cyclograpsus cinereus and Petrolisthes granulosus, on the rocky shores of Cifuncho Bay, an isolated bay in the north of Chile. The results revealed that both species had a uniform pattern, that was adjusted to a binomial distribution for C. cinereus, and a Poisson distribution for P. granulosus. These results are probably due to territorial behaviour, and this was corroborated by the results of the contingency table, which denoted the independence of both species. These results would not coincide with classical observations of intertidal decapods on rocky shores of continental Chile, as those denoted a gregarious pattern. However, on the other hand, the present results do not explain any details about potential interactions between the two species here analysed.
Pyrrho and Vagueness: A Fregean Analysis
Authors: Güremen Refik
Published: October 2023

Pyrrho of Elis advises us not to trust our sensations and opinions, but instead to be without opinions about individual things. He suggests that such a state is to be achieved by saying, concerning each individual thing, that it is “no more” a certain way than it is not. This paper argues that the current metaphysical reading of Pyrrho’s views falls short of explaining why we should not trust our sensations and opinions; in addition, it does not explain how to achieve the state of being “without opinions” about individual things. It is argued that a Fregean analysis of Pyrrho’s views can provide satisfactory answers to both questions. The purpose of the paper, however, is to refine, rather than rebut, the metaphysical reading.
Some Evidence That Truth-Tellers Are More Attractive Than Liars
Authors: ten Brinke Leanne , Raymundo Isaac , Mukherjee Merusha , Carney Dana R.
Published: October 2023

Despite the prevalence of deception, people rarely doubt others’ sincerity. However, indirect evaluations of liars and truth-tellers may differ even in the absence of suspicion about veracity. Across three studies, we provide evidence for the truth attraction effect in two samples of target stimuli and three samples of participant judges. Target people are perceived as more attractive when telling the truth versus when they lie, an effect mediated by target warmth and openness. The truth attraction effect is stronger for female targets (vs. males); however, it is unaffected by the gender of the judge. Findings suggest people may be more likely to approach truth-tellers versus liars, even when not actively judging veracity. We discuss the challenges and benefits of treating both targets and participants as random factors in linear mixed-effect analyses and join the chorus of calls to increase the number of target stimuli in deception research.
Does Dance Expertise Enhance Sensitivity? A Comparative Study
Authors: Izountouemoi Anna , Esteves Francisco
Published: October 2023

The overall aim was to study the impact of dance expertise in relation to emotional expressivity and emotional sensitivity, by comparing dance experts and nonexperts. The results are based on a survey answered by 120 individuals, consisting of the Berkeley Emotional Expressivity Questionnaire (BEQ) and the Emotional Sensitivity Questionnaire (ESS). Dance experts in comparison to nonexperts scored higher on ESS, more specifically, other-directed sensitivity, that is, the positive interpersonal sensitivity subscale. No significant differences were obtained on negative egocentric sensitivity, the other subscale of ESS, and neither regarding emotional expressivity. However, it was found that those with more frequent dance habits scored higher on the Impulse Strength subscale of the BEQ. Our findings point out the relationship between dance and our ability to perceive emotions, which could have interesting educational and clinical implications. Lastly, we discuss current and future perspectives on the topic.
A text mining approach to the use of “groove” in everyday language
Authors: Stupacher Jan , Bechtold Toni , Senn Olivier
Published: October 2023

When speaking about music, the term groove can refer to objective qualities, such as rhythmic patterns, or to subjective experiences, such as the pleasurable urge to move to the music. However, the mere juxtaposition of objective musical causes and subjective psychological effects may be too simplistic to fully capture the multifaceted groove phenomenon. We therefore broaden the perspective of groove research by analyzing how people use the term groove in the everyday language of 970,220 comments on 155 YouTube music videos. The corresponding songs were previously rated on groove, operationalized as a pleasurable urge to move. Results show that groove terms were more likely to be used in comments on songs that received higher groove ratings. Resonating with the definition of groove as a pleasurable urge to move, groove terms were very likely to co-occur with movement terms, and comments mentioning groove expressed more positive sentiments. We also found that groove terms were predominantly used to describe objective musical qualities in comments on funk, soul, and R&B songs, suggesting that the use of groove is related to genre. In general, we demonstrate how text mining can be used to review existing definitions and gain new perspectives on current topics in music science.
Deep Q-Network-Enabled Platoon Merging Approach for Autonomous Vehicles
Authors: Wang Jiawen , Hu Chenxi , Zhao Jing , Zhang Lingzhi , Han Yin
Published: October 2023

Platoon merging control of autonomous vehicles driving in a platoon formation can improve traffic efficiency. However, current platoon merging control approaches primarily rely on rules, making it challenging to achieve optimal control. In this study, we propose a platoon merging control approach based on a deep Q-network (DQN). First, we specify the state and action of the vehicle and establish a set of reward functions to ensure safe driving. Then, the DQN algorithm is used to train a neural network suitable for merging the controls of connected and automated vehicles (CAVs) to continuously approach the state-value function. Finally, we compare the proposed approach with a rule-based (RB) vehicle merging approach using a MATLAB simulation. In particular, CAVs are driven simultaneously using the two approaches in a random environment. The simulation results show that the proposed DQN-based vehicle merging approach requires less merging travel time and fewer vehicle lane change times than the RB approach. Additionally, merging can result in improved capacity in medium and high traffic densities compared with no-merging: the higher the CAV penetration rate, the larger the improvement. We verify the effectiveness of the proposed approach for different initial conditions. We suggest that the proposed method is a safe and robust method for CAV platoon merging, and that it can be applied to increase the capacity of freeways and roads.
Medical Assistance in Dying for Mental Illness as a Sole Underlying Medical Condition and Its Relationship to Suicide: A Qualitative Lived Experience-Engaged Study: Aide Médicale à Mourir Pour Maladie Mentale Comme Seule Condition Médicale Sous-Jacente et Son Lien Avec le Suicide: Une Etude Qualitative Engagée Dans l’Expérience Vécue
Authors: Hawke Lisa D. , Bastidas-Bilbao Hamer , Cappe Vivien , van Kesteren Mary Rose , Stewart Donna E. , Gupta Mona , Simpson Alexander I. F. , Campbell Bartholemew H. , Castle David , Stergiopoulos Vicky ,   the MAiD Study Team at the Centre for Addiction and Mental Health
Published: October 2023

Objective

This lived experience-engaged study aims to understand patient and family perspectives on the relationship between suicidality and medical assistance in dying when the sole underlying medical condition is mental illness (MAiD MI-SUMC).

Method

Thirty individuals with mental illness (age M = 41.8 years, SD = 14.2) and 25 family members (age M = 47.5 years, SD = 16.0) participated in qualitative interviews examining perspectives on MAiD MI-SUMC and its relationship with suicide. Audio recordings were transcribed and analysed using reflexive thematic analysis. People with lived experience were engaged in the research process as team members.

Results

Four main themes were developed, which were consistent across individuals with mental illness and family members: (a) deciding to die is an individual choice to end the ongoing intolerable suffering of people with mental illness; (b) MAiD MI-SUMC is the same as suicide because the end result is death, although suicide can be more impulsive; (c) MAiD MI-SUMC is a humane, dignified, safe, nonstigmatized alternative to suicide; and (4) suicidality should be considered when MAiD MI-SUMC is requested, but suicidality's role is multifaceted given its diverse manifestations.

Conclusion

For patient-oriented mental health policy and treatment, it is critical that the voices of people with lived experience be heard on the issue of MAiD MI-SUMC. Given the important intersections between MAiD MI-SUMC and suicidality and the context of suicide prevention, the role that suicidality should play in MAiD MI-SUMC is multifaceted. Future research and policy development are required to ensure that patient and family perspectives guide the development and implementation of MAiD MI-SUMC policy and practice.
Examining Relationships Between Field Placements and Preservice Teachers’ Self-Efficacy and Career Plans
Authors: Shaheen Tashnuva , Mathews Hannah , Bettini Elizabeth , Jones Nathan
Published: October 2023

Field placements are arguably the most crucial component of traditional preservice special education teacher preparation. In field placements, cooperating teachers and university supervisors foster preservice special educators’ sense of efficacy to teach, supporting their investment in continuing in the profession. Although ample research indicates the importance of cooperating teachers for preservice teachers’ outcomes, little of this research has been conducted with preservice special educators. Moreover, prior research has almost never focused on university supervisors, despite their critical role bridging the relationship between content learned in coursework and the applied practice of special education within placement schools. In this investigation, we examined how preservice special educators’ experiences of support from cooperating teachers and university supervisors relate to their teacher self-efficacy and their plans to teach. Analyzing a survey of 154 preservice special educators from six traditional preparation programs, we found that perceptions of university supervisors’ support significantly predicted both self-efficacy and plans to teach, whereas perceptions of support from cooperating teachers were unrelated to either outcome. Our findings indicate that university supervisors’ roles are crucial for preservice special educators’ outcomes, and thus that they could be an important leverage point for improving special education teacher preparation. We call for much more extensive research on university supervisors’ roles.