bluuebunny/crossref_metadata_2025 huggingface dataset:
Lobar emphysema ratio of more than 1% in the lobe with lung cancer as poor predictor for recurrence and overall survival in patients with stage I non-small cell lung cancer
Authors: Lee Jeong Pyo , Na Jae Bum , Choi Ho Cheol , Choi Hye Young , Kim Ji Eun , Shin Hwa Seon , Won Jung Ho , Jo Sa Hong , Hong Seok Jin , Yang Won Jeong , Kim Yang Won , Koo Byeong Ju , Jang In Seok , Park Mi Jung
Published: February 2023

Background

The purpose of this study was to examine the relationship between the lobar emphysema ratio (LER) and tumor recurrence and survival in patients with stage I non-small cell lung cancer (NSCLC).

Methods

We enrolled 258 patients with surgically proven stage I NSCLC. These patients underwent noncontrast chest CT, and pulmonary lobe segmentation and lobar emphysema quantification were performed using commercially available software. We assessed the LER in the lobe with lung cancer. We divided the patients into two groups according to the LER, and the cut-off value was 1. Furthermore, we analyzed the disease-free survival of high LER and other clinical factors after surgical resection.

Results

The 258 patients were divided into two groups: low LER (n = 195) and high LER (n = 63). The right upper lobe was the most frequent location in lung cancer and the most severe location in emphysema. In the Kaplan‒Meier curve, high LER showed a significantly lower disease-free survival (8.21 ± 0.27 years vs 6.53 ± 0.60 years, p = 0.005) and overall survival (9.56 ± 0.15 years vs. 8.51 ± 0.49 years, p = 0.011) than low LER. Stage Ib (2.812 [1.661–4.762], p<0.001) and high LER (2.062 [1.191–3.571], p = 0.010) were poor predictors for disease-free survival in multivariate Cox regression analysis. Stage Ib (4.729 [1.674–13.356], p = 0.003) and high LER (3.346 [1.208–9.269], p = 0.020) were significant predictors for overall survival in multivariate Cox regression analysis.

Conclusion

A LER of more than 1% in the lobe with lung cancer is a poor predictor for cancer recurrence and overall survival in patients with stage I NSCLC.
Health-related quality of life and its associated factors among patients with asthma: A multi-centered cross-sectional study in selected referral hospitals in Northwest Ethiopia
Authors: Belachew Eyayaw Ashete , Sendekie Ashenafi Kibret , Tadess Sumeya , Alemayehu Mekuriaw
Published: February 2023

Background

Patients with asthma have a compromised health-related quality of life (HRQoL) due to factors related sociodemographic, clinical, and environmental factors. This study assessed the HRQoL and its determinants in patients with asthma in selected public referral hospitals in Northwest Ethiopia.

Design, setting, and participants

A multicenter facility-based cross-sectional study was conducted in selected hospitals in Northwest Ethiopia from August to October 2021. Participants were enrolled in the study using a systematic random sampling technique.

Main outcome measures

HRQoL was assessed using the asthma-specific quality of life tool Mini-Asthma Quality of Life Questionnaire (Mini-AQLQ). Simple and multivariable linear regression analyses were conducted to determine the association between independent variables and HRQoL. A p-value of < 0.05 at 95% CI was considered statistically significant.

Results

A total of 409 patients were included in the final analysis, and more than half (59.2%) of the subjects had a good health-related quality of life. Regarding HRQoL determinants, asthma control score (β = 0.14, 95% CI: 0.09, 0.17; p 0.001), insurance user (β = 0.15, 95% CI: 0.01, 0.29); p = 0.042), the high role of patient enablement (β = 0.39, 95% CI: 0.25, 0.54; p 0.001), belief in asthma medication (β = -0.23, 95% CI: -0.36, -0.10;p = 0.001), non-adherence to guidelines (β = -0.30, 95% CI: -0.47, -0.15; p < 0.001), and being homemaker (β = -0.21, 95% CI: -0.39, -0.01; p = 0.040) were the significant predictors of HRQoL.

Conclusion

Overall, more than half of the study participants were found to have good HRQoL. HRQoL among adults with asthma was largely dependent on the level of asthma control. Socio-demographic, clinical, healthcare-related, and medication-related variables were significantly associated with health-related quality of life. Therefore, healthcare providers should include comprehensive asthma education along with an integrated treatment plan to improve asthma control and the HRQoL of patients.
Respiratory system impedance in different decubitus evaluated by impulse oscillometry in individuals with obesity
Authors: Holtz Mayara , Perossi Larissa , Perossi Jéssica , Oliveira dos Santos Daniele , de Souza Hugo Celso Dutra , Gastaldi Ada Clarice
Published: February 2023

Background and objective

The body posture can influence gas exchange, respiratory mechanics, and mucociliary clearance and different positions can be used as a therapeutic strategy to improve in gas exchange and can also help physiotherapists to assist patients who have difficult or restrictions to stay seated or the ones who stay in the same position for a long period. The objective of this study was to evaluate the effect of different positions on respiratory system impedance in obese and eutrophic subjects, using Impulse Oscillometry System (IOS).

Methods

The IOS parameters were evaluated in seated (Se), right lateral decubitus (RL), left lateral decubitus (LL), and supine (Su).

Results

Sixty two volunteers were allocated in obese group (OG) or eutrophic group (EG) according to BMI. In seated position, OG showed higher impedance than EG for R5: 0.55 (0.31; 0.93) and 0.33 (0.24; 0.52); R20: 0.39 (0.23; 0.54) and 0.32 (0.03; 0.41); R5-R20: 0.13 (0.02; 0.47) and 0.01 (-0.08; 0.27); X5: -0.20 (-0.51; 0.16) and -0,10 (-0.016; -0.04); Fres: 20.59 (11.54; 36.45 and 10.69 (7.56; 24.7) (p<0.05) and the impedance were higher in the Su for both groups. Compared to Se, there were differences with Su (R5, R5-20, X5), with RL (R20), and with LL (R5, R20) for OG; and with Su (R5, R5-20, X5, Fres), with RL and LL (X5) for EG. Compared to Su, there were differences with RL and LL (R5-20, X5) for OG; and with RL (R5, R5-20, X5, Fres), and LL (R5-20, X5, Fres) for EG. There were no differences between RL and LL for OG and EG.

Conclusion

The respiratory system impedance is increased in OG, with greater contribution of peripheral resistance. The higher values of resistance and reactance were obtained in the supine position, in both groups, with lower differences obtained in the right and left lateral decubitus.
A kompetenciaalapú szemlélet a bölcsődepedagógiában
Authors: Nyitrai Ágnes
Published: February 2023

Nagy József kritériumorientált, kompetenciaalapú pedagógiai
elméletében a személyiség valamennyi kompetenciaterülete értelmezhető
(Nagy, 2007, 2010), a fejlődés kritériumorientált segítése jól illeszkedik
az egyes gyermekek fejlődéséhez, ténylegesen adaptív tevékenységeket alapoz
meg. A gyermekek fejlődésének támogatása az egyes kompetenciaterületeken
elérhető optimális fejlettség eléréséig tart. Ez a pedagógiai elmélet a
neveléstudomány rendszerében jelenleg helyét kereső bölcsődepedagógia
értelmezési keretéül is szolgálhat, elősegítheti a bölcsődei
szakmai-módszertani kultúra rendszerbe foglalását, fejlesztését, támogatja
a szakemberképzés és -továbbképzés korszerűsítését, elősegíti a kora
gyermekkori neveléshez kapcsolódó kutatások tervezését. A tanulmány a
kompetenciaalapú kritériumorientált pedagógia és a bölcsődei nevelést
megalapozó pedagógiai kultúra kapcsolódásait mutatja be.
Óriáslépések a pedagógiában: az óvodás és kisiskolás gyermekek
fejlesztése
Authors: Józsa Krisztián
Published: February 2023

A tanulmány Nagy József (1930–2021) szakmai munkássága előtti
tisztelgés. Nagy József a 20. század második felének és az ezredforduló
éveinek a legkiemelkedőbb magyar neveléstudományi kutatója. Mintegy hat
évtizednyi munkássága alatt a magyar neveléstudományi kutatást és ehhez
kapcsolódóan a közoktatási gyakorlatot is több területen megújította.
Értékes munkásságából külön kiemelkedik a kora gyermekkor terültén végzett
több évtizedes kutatása. A 4–8 éves gyermekek készségeinek a vizsgálatára
nemzetközi szinten is egyedülálló tesztrendszert dolgozott ki. Ennek első
változat a hetvenes években jött létre: PREFER (Preventív
fejlettségvizsgáló rendszer), majd egy átdolgozott, továbbfejlesztett
változata a 2000-es évek elején: DIFER programcsomag (Diagnosztikus
fejlődésvizsgáló és kritériumorientált fejlesztő rendszer 4–8 évesek
számára). A DIFER teszteket a magyar óvodák legalább fele használja saját
választása alapján. Az iskolák első osztályaiban törvényileg ajánlott
mérőeszközök. A DIFER készségekre Nagy József és munkatársai fejlesztő
programokat dolgoztak ki, amelyek hatékonyságát pedagógiai kísérletekkel
igazolták. A készségfejlesztő módszerek könyvsorozat formájában jelentek
meg. E munkákban 25 éven át dolgoztam együtt Nagy Józseffel. Tisztelettel
és szeretettel emlékezem egykori mentoromra.
Képességfejlesztő vizuális nevelés
Authors: Kárpáti Andrea
Published: February 2023

Ez a Nagy József munkássága előtt tisztelgő írás művészetpedagógiai
gondolatainak aktualitását a vizuális nevelés területén mutatja be. Nyomon
követve a rajztanításból a kortárs és klasszikus képi nyelv sokoldalú
elsajátítását segítő tantárggyá vált területet, Nagy József felismerte a
vizuális kultúra egyre növekvő jelentőségét, hangsúlyozta szerepét a
személyes és kommunikatív kompetencia fejlesztésében és esélyteremtő erejét
a szociális hátránnyal élők tanításában. Sosem használta ezt a csak
magyarul létező, értelmetlen kifejezést: készségtárgy, viszont támogatta a
területen zajló képességkutatásokat. Gondolatainak hatása a vizuális
kommunikáció, a környezetkultúra és a művészettel nevelés esélyteremtő,
társadalmi érzékenységű programjai tükrében tisztán látható.
Design of neural predictors for predicting and analysing COVID-19 cases in different regions
Authors: Yildirim Sahin , Durmusoglu Asli , Sevim Caglar , Bingol Mehmet Safa , Kalkat Menderes
Published: February 2023

Nowadays, some unexpected viruses are affecting people with many troubles. COVID-19 virus is spread in the world very rapidly. However, it seems that predicting cases and death fatalities is not easy. Artificial neural networks are employed in many areas for predicting the systems parameters in simulation or real-time approaches. This paper presents the design of neural predictors for analysing the cases of COVID-19 in three countries. Three countries were selected because of their different regions. Especially, these major countries cases were selected for predicting future effects. Furthermore, three types of neural network predictors were employed to analyse COVID-19 cases. NAR-NN is one of the proposed neural networks that have three layers with one input layer neurons, hidden layer neurons and an output layer with fifteen neurons. Each neuron consisted of the activation functions of the tan-sigmoid. The other proposed neural network, ANFIS, consists of five layers with two inputs and one output and ARIMA uses four iterative steps to predict. The proposed neural network types have been selected from many other types of neural network types. These neural network structures are feed-forward types rather than recurrent neural networks. Learning time is better and faster than other types of networks. Finally, three types of neural predictors were used to predict the cases. The R2 and MSE results improved that three types of neural networks have good performance to predict and analyse three region cases of countries.
Role of virtual reality in the life of ageing population
Authors: Lhotska Lenka , Husák Jan , Stejskal Jakub , Kotek Martin , Dolezal Jaromir , Adolf Jindrich
Published: February 2023

Virtual reality (VR) has been on the scene for several decades already. Its first applications were in gaming. However, hardware and software were expensive and thus not for everybody. Since that time, the development of technology proceeded fast and enabled to open new application areas for VR. Currently many commercial systems are available for gaming, training and education, simulations, design, and also for medical purposes. In the article we focus on VR applications in healthcare. First we present existing commercial solutions, and research studies showing the potential of VR in healthcare. In recent years there have appeared many interesting projects and applications aimed at ageing population as target users. We present examples of such projects. Based on our previous experience and after analysis of available solutions, we propose a conceptual architecture od software environment for development of such applications and discuss their potential use. Finally, the implementation of the proposed architecture for interactive application of experience sets is described.
The geoenvironmental susceptibility of the Ribeirão Lajeado watershed – Tocantins
Authors: Ribeiro Lucas Silva , Robaina Luís Eduardo Souza , Cristo Sandro Sidnei Vargas
Published: February 2023

The geoenvironmental study through the integration of natural elements with the use and land cover is a methodological proposal for strategic planning. In this sense, the objective of this article is to perform an analysis of geoenvironmental susceptibility from the use of multicriteria in the watershed of Ribeirão Lajeado. For this, the organization of cartographic materials was carried out, such as the drainage network, slope, lithology, soils, land use and cover and access routes, where normalized weights were established from the technique of the Hierarchical Analytical Process (AHP). This crossing generated the geoenvironmental susceptibility map, defined in four units, namely: I) low (flat top area with vegetation cover and no proximity to the access roads); II) medium (places with some human occupations or with wavy smooth relief); III) high (areas with wide occurrence of roads and abundant drainage network, susceptible to anthropic intervention, mainly related to agricultural activities and urban areas) and IV) very high (places with roads and portions of agricultural use with slopes greater than 15%, presence of fire scars and urban areas. Thus, the AHP technique presents itself as an important tool for geoenvironmental, especially in defining weights for the factors analyzed.
Symétries en physique
Authors: Antoine Jean-Pierre
Published: February 2023

Cet article passe en revue les multiples applications de la théorie des groupes aux problèmes de symétrie en physique. En physique classique, il s’agit surtout de la relativité : euclidienne, galiléenne, einsteinienne (relativité restreinte). Passant à la mécanique quantique, on remarque d’abord que les principes de base impliquent que l’espace des états d’un système quantique a une structure intrinsèque d’espace préhilbertien, que l’on complète ensuite en un espace de Hilbert. Dans ce contexte, la description de l’invariance sous un groupe G se base sur une représentation unitaire de G. On parcourt ensuite les différents domaines d’application : physique atomique et moléculaire, matière condensée, optique quantique, ondelettes, symétries internes, symétries approchées. On discute ensuite l’extension aux théories de jauge, en particulier au Modèle Standard des interactions fondamentales. On conclut par quelques indications sur des développements récents.
* * *
The present article reviews the multiple applications of group theory to the symmetry problems in physics. In classical physics, this concerns primarily relativity : Euclidean, Galilean, Einsteinian (special). Going over to quantum mechanics, we first note that the basic principles imply that the state space of a quantum system has an intrinsic structure of pre-Hilbert space, that one completes into a genuine Hilbert space. In this framework, the description of the invariance under a group G is based on a unitary representation of G. Next we survey the various domains of application : atomic and molecular physics, condensed matter physics, quantum optics, wavelets, internal symmetries, approximate symmetries. Next we discuss the extension to gauge theories, in particular to the Standard Model of fundamental interactions. We conclude with some remarks about recent developments.
«Sup en Poche»
Authors: Coulaud Jean-Baptiste , Guillaume Anne-Marie , Bertrand Émilie , Genette Anne
Published: February 2023

Analyse critique de :

Cottet-Émard (François), Toutes les maths pour bien commencer sa licence. – Louvain-la-Neuve : De Boeck Supérieur, 2017. – v, 249 p. – (Sup en poche). – 1 vol. broché de 15 × 21 cm. – 16,00 €. – isbn 978-2-8073-1012-4.

Villain (Loïc), Mécanique du point. – Louvain-la-Neuve : De Boeck Supérieur, 2017. – vi, 249 p. – (Sup en poche). – 1 vol. broché de 15 × 21 cm. – 16,00 €. – isbn 978-2-8073-0766-7.

Taillet (Richard), Optique géométrique. – Louvain-la-Neuve : De Boeck Supérieur, 2017. – viii, 245 p. – (Sup en poche). – 1 vol. broché de 15 × 21 cm. – 16,00 €. – isbn 978-2-8073-0764-3.

Baggio (Stéphanie) - Rothen (Stéphane) - Deline (Stéphane), Statistique descriptive. – Louvain-la-Neuve : De Boeck Supérieur, 2017. – 220 p. – (Sup en poche). – 1 vol. broché de 15 × 21 cm. – 16,00 €. – isbn 978-2-8073-1491-7.
musiciens, la maladie et la médecine
Authors: Caspar Philippe
Published: February 2023

Analyse critique de :

Pinet (Patrice), Les musiciens, la maladie et la médecine de Guillaume de Machaut à Béla Bartók. – Paris : L’Harmattan, 2017. – 409 p. – (Médecine à travers les siècles). – 1 vol. broché de 15,5 × 24 cm. – 39,00 €. – isbn 978-2-343-13073-6.
Compte rendu de Giordano Bruno : «The Ash Wednesday Supper : A New Translation of «La cena de la ceneri» with the Italian Text Annotated and Introduced by Hilary Gatti»
Authors: Seidengart Jean
Published: February 2023

Bruno (Giordano), The ash wednesday supper / A new translation of « La cena de le ceneri » with the Italian text annotated and introduced by Hilary Gatti. – Toronto ; Buffalo ; London : University of Toronto Press, 2018. – lxiv, 302 p. – (The Lorenzo Da Ponte italian library). – 1 vol. relié de 16,5 × 23,4 cm. – $85,00. – isbn 978-1-4875-0144-0
Compte rendu de Vincent Albouy : «Étonnants envahisseurs : ces espèces venues d’ailleurs»
Authors: Micha Jean-Claude
Published: February 2023

Albouy (Vincent), Étonnants envahisseurs : ces espèces venues d’ailleurs. – Versailles : Éditions Quae, 2017. – 159 p. – 1 vol. électronique. – 16,00 €. – isbn 978-2-7592-2662-7.
Compte rendu de Marie-Chantal Morel-Bracq (sous la direction de) : «Les modèles conceptuels en ergothérapie : introduction aux concepts fondamentaux»
Authors: Terrana Gwendoline , Terrier Florence
Published: February 2023

Les modèles conceptuels en ergothérapie : introduction aux concepts fondamentaux / sous la direction de Marie-Chantal Morel-Bracq ; [préface de Hélène Hernandez]. – 2e édition. – Louvain-la-Neuve : De Boeck Supérieur, 2017. – ix, 261 p. – 1 vol. broché de 16 × 24 cm. – 29,00 €. – isbn 978-2-35327-377-5.
Compte rendu de Jean-Marc Ginoux : «Pour en finir avec le mythe d’Albert Einstein»
Authors: Dhombres Jean
Published: February 2023

Ginoux (Jean-Marc), Pour en finir avec le mythe d’Albert Einstein. – Paris : Hermann, 2019. – 302 p. – 1 vol. broché de 15 × 21 cm. – 23,00 €. – isbn 979-10-370-0101-6.
Paul Mansion (1844-1919)
Authors: Mawhin Jean
Published: February 2023

Les contributions de Paul Mansion aux mathématiques sont illustrées par son action pour l’emploi de la théorie des limites en géométrie élémentaire, par une description de son ouvrage Résumé d’analyse infinitésimale utilisé pour l’enseignement de cette branche à l’Université de Gand, par la discussion de son point de vue sur les infiniment petits et par l’étude de l’influence de son confrère De Tilly sur ses contributions à la géométrie non euclidienne. On discute enfin le rôle de Mansion comme animateur des mathématiques en Belgique.

* * *

The mathematical contributions of Paul Mansion to mathematics are illustrated by his action toward using the theory of limits in elementary geometry, by describing his textbook Résumé d’analyse infinitésimale used in his teaching of this discipline at the University of Gand, by discussing his viewpoint about the infinitesimals and by studying the influence of his fellow-member De Tilly on his contributions to non-Euclidian geometry. Finally, the role of Mansion in promoting mathematics in Belgium is emphasized.
L’idée de «Mathesis universalis» chez Leibniz
Authors: Radelet-de Grave Patricia
Published: February 2023

Analyse critique de :

Leibniz (Gottfried Wilhelm), Mathesis universalis : écrits sur la mathématique universelle / textes introduits, traduits et annotés sous la direction de David Rabouin. – Paris : Vrin, 2018. – 256 p. – (Mathesis). – 1 vol. broché de 13,5 × 21,5 cm. – 23,00 €. – isbn 978-2-7116-2816-2.
Compte rendu de Michael Heller : «God and Geometry: When Space Was God»
Authors: Maldamé Jean-Michel
Published: February 2023

Heller (Michael), God and Geometry : When Space Was God / translated by Piotr Krasnowolski. – Kraków : Copernicus Center Press, 2019. – 224 p. – 1 vol. broché de 16,5 × 24 cm. – 40,39 €. – isbn 978-83-7886-396-0.
Compte rendu de Michel Oury : «Chasseur de comètes : la quête de nos origines»
Authors: Antoine Jean-Pierre
Published: February 2023

Ory (Michel), Chasseur de comètes : la quête de nos origines. – Louvain-la-Neuve : De Boeck supérieur, 2021. – xvii + 168 p. – 1 vol. broché de 15 × 21 cm. – isbn 978-2-8073-3490-8.
Compte rendu de William R. Shea : «Ce que Galilée dit à Milton: dialogue entre le savant et le poète»
Authors: Stoffel Jean-François
Published: February 2023

Shea (William R.), Ce que Galilée dit à Milton : dialogue entre le savant et le poète. – Paris : Les Belles Lettres ; Montréal : Éditions Liber, 2021. – 102 p. – 1 vol. broché de 15 × 20 cm. – 17,00 €. – isbn 978-2-251-45230-2.
Compte rendu de Christian Lévêque : «Quelles rivières pour demain ? Réflexions sur l’écologie et la restauration des cours d’eau»
Authors: Micha Jean-Claude
Published: February 2023

Lévêque (Christian), Quelles rivières pour demain ? Réflexions sur l’écologie et la restauration des cours d’eau. – Versailles : Éditions Quae, 2021. – 288 p. – 1 vol. relié de 16 × 24 cm. – 36,00 €. – isbn 978-2-7592-3319-9.
Examining Classroom Contexts in Support of Culturally Diverse Learners’ Engagement: An Integration of Self-Regulated Learning and Culturally Responsive Pedagogical Practices.
Authors: Anyichie Aloysius C. , Butler Deborah L. , Perry Nancy E. , Nashon Samson M.
Published: February 2023

Research shows that culturally diverse students are often disengaged in multicultural classrooms. To address this challenge, literatures on self-regulated learning (SRL) and culturally responsive teaching (CRT) both document practices that foster engagement, although from different perspectives. This study examined how classroom teachers at schools that enrol students from diverse cultural communities on the West Coast of Canada built on a Culturally Responsive Self-Regulated Learning Framework to design complex tasks that integrated SRL pedagogical practices (SLPPs) and culturally-responsive pedagogical practices (CRPPs) to support student engagement. Two elementary school teachers and their 43 students (i.e., grades 4 and 5) participated in this study. We used a multiple, parallel case study design that embedded mixed methods approaches to examine how the teachers integrated SRLPPs and CRPPs into complex tasks; how culturally diverse students engaged in each teacher’s task; and how students’ experiences of engagement were related to their teachers' practices. We generated evidence through video-taped classroom observations, records of classroom practices, students’ work samples, a student self-report, and teacher interviews. Overall findings showed: (1) that teachers were able to build on the CR-SRL framework to guide their design of an CR-SRL complex task; (2) benefits to students’ engagement when those practices were present; and (3) dynamic learner-context interactions in that student engagement was situated in features of the complex task that were present on a given day. We close by highlighting implications of these findings, limitations, and future directions.
An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of lamotrigine in human serum and plasma
Authors: Salzmann Linda , Spescha Tino , Singh Neeraj , Schierscher Tobias , Bachmann Martina , Bauland Friederike , Geistanger Andrea , Risch Lorenz , Geletneky Christian , Seger Christoph , Taibon Judith
Published: February 2023

Objectives

We developed an isotope dilution (ID)-liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based candidate reference measurement procedure (RMP) for lamotrigine in human serum and plasma, using quantitative nuclear magnetic resonance-characterized reference standards to ensure traceability to the International System of Units.

Methods

A sample preparation protocol based on protein precipitation combined with LC-MS/MS analysis using a C18 column for chromatographic separation was established for the quantification of lamotrigine in human serum and plasma. Assay validation was performed according to current guidelines. Spiked serum and plasma samples were used to assess selectivity and specificity; a post-column infusion experiment and comparison of standard line slopes were performed to ascertain possible matrix effects. Precision and accuracy were determined in a 5 days validation experiment. Measurement uncertainty was determined per the Guide to the Expression of Uncertainty in Measurement.

Results

The method allowed the quantification of lamotrigine in serum and plasma in a range of 0.600–24.0 μg/mL without any observable matrix effects. The relative mean bias (n=6) ranged from 1.7 to 3.7%; intermediate precision, including variances in between-day, -calibration, and -injection, was ≤2.4%, independent of the level and matrix. Total measurement uncertainty for a single measurement was ≤2.6%; expanded uncertainty was ≤5.2% (coverage factor k=2).

Conclusions

This candidate RMP based on ID-LC-MS/MS provides a traceable and reliable platform for the standardization of routine assays and the evaluation of clinical samples.
Fractional Laplacian – Quadrature Rules for Singular Double Integrals in 3D
Authors: Feist Bernd , Bebendorf Mario
Published: February 2023

In this article, quadrature rules for the efficient computation of the stiffness matrix for the fractional Laplacian in three dimensions are presented.
These rules are based on the Duffy transformation, which is a common tool for singularity removal.
Here, this transformation is adapted to the needs of the fractional Laplacian in three dimensions.
The integrals resulting from this Duffy transformation are regular integrals over less-dimensional domains.
We present bounds on the number of Gauss points to guarantee error estimates which are of the same order of magnitude as the finite element error.
The methods presented in this article can easily be adapted to other singular double integrals in three dimensions with algebraic singularities.
Motivation and growth in kanji proficiency: a longitudinal study using latent growth curve modeling
Authors: Tanaka Mitsuko
Published: February 2023

Despite the well acknowledged importance of motivation in second language (L2) learning, longitudinal research regarding the effects of motivation on growth in L2 proficiency remains limited. Furthermore, limited investigation has been done on how motivation and L2 proficiency interactively develop and affect each other. Thus, this study examined the impact of motivation on growth in kanji proficiency and the dual developmental trajectories of motivation and kanji proficiency using the self-determination theory. Learners of Japanese with Chinese as their First language (L1) responded to a questionnaire and took kanji tests three times in one academic semester (n = 192). The results of the univariate latent growth curve (LGC) modeling identified intrinsic motivation and introjected regulation as positive and negative predictors, respectively, of kanji proficiency growth, suggesting the importance of enjoyment and the detrimental nature of introjected regulation in kanji learning by L1 Chinese learners. The results of multivariate LGC modeling demonstrated a lack of reciprocal developmental association between kanji proficiency and intrinsic motivation. Moreover, perceived competence rather than actual growth in kanji proficiency influenced the enhancement of intrinsic motivation, indicating the importance of subjective interpretations of L2 development in promoting motivation.
Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis
Authors: Zhang Chengkai , Zhou Wenjianlong , Zhang Dainan , Ma Shunchang , Wang Xi , Jia Wang , Guan Xiudong , Qian Ke
Published: February 2023

More clinical evidence is needed regarding the relative priority of treatments for brain metastases (BMs) from EGFR/ALK-negative/unselected non-small cell lung cancer (NSCLC). PubMed, EMBASE, Web of Science, Cochrane Library, and ClinicalTrials.gov databases were searched. Overall survival (OS), central nervous system progression-free survival (CNS-PFS), and objective response rate (ORR) were selected for Bayesian network meta-analyses. We included 25 eligible randomized control trials (RCTs) involving 3,054 patients, investigating nine kinds of treatments for newly diagnosed BMs and seven kinds of treatments for previously treated BMs. For newly diagnosed BMs, adding chemotherapy, EGFR-TKIs, and other innovative systemic agents (temozolomide, nitroglycerin, endostar, enzastaurin, and veliparib) to radiotherapy did not significantly prolong OS than radiotherapy alone; whereas radiotherapy + nitroglycerin showed significantly better CNS-PFS and ORR. Surgery could significantly prolong OS (hazard ratios [HR]: 0.52, 95% credible intervals: 0.41–0.67) and CNS-PFS (HR: 0.32, 95% confidence interval: 0.18–0.59) compared with radiotherapy alone. For previously treated BMs, pembrolizumab + chemotherapy, nivolumab + ipilimumab, and cemiplimab significantly prolonged OS than chemotherapy alone. Pembrolizumab + chemotherapy also showed better CNS-PFS and ORR than chemotherapy. In summary, immune checkpoint inhibitor (ICI)-based therapies, especially ICI-combined therapies, showed promising efficacies for previously treated BMs from EGFR/ALK-negative/unselected NSCLC. The value of surgery should also be emphasized. The result should be further confirmed by RCTs.
High-performance waveguide coupled Germanium-on-silicon single-photon avalanche diode with independently controllable absorption and multiplication
Authors: Wang Heqing , Shi Yang , Zuo Yan , Yu Yu , Lei Lei , Zhang Xinliang , Qian Zhengfang
Published: February 2023

Germanium-on-silicon (Ge-on-Si) single photon avalanche diodes (SPADs) have received wide attention in recent years due to their potential to be integrated with Si photonics. In this work, we propose and demonstrate a high-performance waveguide coupled Ge-on-Si separate-absorption-charge-multiplication SPAD with three electric terminals. By providing two separate voltage drops on the light absorption and multiplication regions, the drift and multiplication of carriers can be optimized separately. This indeed improves the freedom of voltage regulation for both areas. Moreover, thanks to the separate controlling, doping profile of the charge layer is greatly released compared to that of the conventional device because of the flexible carrier injection. In this scenario, the dark counts of the detector can be largely reduced through decreasing the electric field on the sidewalls of the Ge absorption region without affecting the detection efficiency. The proposed SPAD exhibits a high on-chip single photon detection efficiency of 34.62% and low dark count rates of 279 kHz at 1310 nm with the temperature of 78 K. The noise equivalent power is as low as 3.27 × 10−16 WHz−1/2, which is, to the best of our knowledge, the lowest of that of the reported waveguide coupled Ge-on-Si SPADs. This three-terminal SPAD enables high-yield fabrication and provides robust performance in operation, showing a wide application prospect in applications such as on-chip quantum communication and lidar.
The crystal structure of N′1,N′2-bis((E)-3-(tert-butyl)-2-hydroxybenzylidene)oxalohydrazide, C24H30N4O4
Authors: Xiao Zhenxiu , Wang Tiantian , Deng Xin , Jiang Wujiu , Tan Yuxing
Published: February 2023

C24H30N4O4, monoclinic, C2/c (no. 15), a = 21.170(3) Å, b = 13.2938(17) Å, c = 9.7133(12) Å, β = 114.423(2)°, V = 2489.0(5) Å3, Z = 4, Rgt
(F) = 0.0473, wRref
(F
2) = 0.1424, T = 296(2) K.
The crystal structure of trimethyl 2,2′,2′′-(benzene-1,3,5-triyltris(oxy))triacetate, C15H18O9
Authors: Wang Tiantian , Su Yizi , Feng Yunyun , Tan Yuxing
Published: February 2023

C15H18O9, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 8.4962(7) Å, b = 8.6835(7) Å, c = 11.9767(10) Å, α = 90.9650(10)°, β = 94.9460(10)°, γ = 115.9310(10)°, V = 790.21(11) Å3, Z = 2, R

gt
(F) = 0.0318, wR

ref
(F
2) = 0.0855, T = 296(2) K.
Matrix metalloproteinase 9 gene-MMP9-DNA methylation status in Turkish schizophrenia patients
Authors: Karaaslan Ezgi , Kartalci Şükrü , Bağ Harika Gözde Gözükara , Acar Ceren
Published: February 2023

Objectives

Schizophrenia is a neuropsychiatric disease caused by disorders in brain development due to genetic and environmental factors. The interactions and mechanisms of the two main etiological factors are not fully understood despite neurobiological, clinical and genetic research and more research is needed. In this study, we aimed to investigate the DNA methylation differences in the matrix metalloproteinase 9 gene (MMP9) between schizophrenia and healthy control groups.

Methods

Our study investigates DNA methylation patterns in the MMP9 gene in peripheral blood cells of schizophrenia patients. For this purpose, pyrosequencing method was used to analyze DNA methylation status of C-phosphate-G (CpG) regions in the 7th exon of MMP9 in 40 schizophrenia patients and 32 healthy individuals who admitted to our university hospital’s psychiatry clinic.

Results

In our results, it has been shown that there is a difference between MMP9 gene DNA methylations between healthy individuals and schizophrenia patients. Significant differences were found in the MMP9 gene exon 7 region in CpG 7-3, CpG 7-4, CpG 7-5 positions and mean methylation patterns between these two groups.

Conclusions

This study provided evidence that DNA methylation differences may exist between schizophrenia patients and healthy individuals, and emphasized the epigenetic aspect of the disorder.
Una experiencia práctica pre-profesional comunitaria vinculada con la docencia en Comunicación Social
Authors: Cruz Vilain Margarita Amalia , González Borges María de los Ángeles , Duvergel Isaac Mercedes
Published: February 2023

Como vía de comunicación alternativa, la comunicación comunitaria es por esencia una herramienta para conferir voz a los grupos sociales vulnerables e históricamente marginados, supuesto que precisa ser visualizado cada día como referente para condicionar cambios sociales en las comunidades mediante la educación. El trabajo tiene como meta exponer algunas experiencias como docentes junto a estudiantes de la carrera de Comunicación Social en algunos barrios de Cuito/Bié, Angola. La experiencia derivó en aprendizajes interculturales compartidos entre alumnos y profesores. Se apoyó en herramientas de la metodología de la Investigación -Acción -Participativa y los postulados de la Educación Popular. No se pretende expresar ideas acabadas, sino provocar acercamientos reflexivos sobre una práctica que se reconstruye continuamente. Como docentes de la Escuela Superior Politécnica de Cuito/Bié, en Angola, se aprovechó la oportunidad que propiciaba la coincidencia de la impartición en el quinto semestre de la carrera, de las asignaturas de Comunicación y Salud y Comunicación Educativa, con la precedencia de haber estudiado Comunicación para el Desarrollo y Comunicación Intercultural en el 2do año, para que los estudiantes, integrados en equipos, realizaran trabajo de campo en algunos barrios de la comunidad, todo ello con el objetivo que aplicaran en la práctica, los conocimientos adquiridos en varias asignaturas. Las visitas a la comunidad con la preparación de los contenidos estudiados, fueron consolidando las vivencias de los estudiantes, permitieron realizar observaciones en el terreno y fortalecer el proceso de interacción entre la teoría y la práctica, utilizando herramientas propias de la metodología de investigación, como entrevistas, guías de observación, cuestionarios y la interacción cara a cara casi diaria con los moradores le dio objetividad científica a la tarea realizada. Se pudo constatar las condiciones de insalubridad de las zonas pesquisadas, las prácticas de vida poco saludables de muchos de sus moradores en su interacción con el medio ambiente, el no aprovechamiento de los líderes naturales de esas comunidades para el mejoramiento de las mismas, así como insuficiente comunicación entre la comunidad y las instituciones cercanas a éstas fundamentalmente. La experiencia corroboro de manera concluyente las debilidades que aún existen en el trabajo extensionista por parte de la universidad, que el trabajo comunitario es espacio casi invisibilizado por los grandes medios de comunicación y las universidades del territorio, ademas permitió a los estudiantes tener una mirada otra de las prácticas culturales y comunicativas del entorno en cuestión. Las evidencias fotograficas ilustran lo anteriormente expuesto.
Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition
Authors: Pitcairn Caleb , Murata Naomi , Zalon Annie J. , Stojkovska Iva , Mazzulli Joseph R.
Published: February 2023

Macroautophagy is a catabolic process that coordinates with lysosomes to degrade aggregation-prone proteins and damaged organelles. Loss of macroautophagy preferentially affects neuron viability and is associated with age-related neurodegeneration. We previously found that α-synuclein (α-syn) inhibits lysosomal function by blocking ykt6, a farnesyl-regulated soluble NSF attachment protein receptor (SNARE) protein that is essential for hydrolase trafficking in midbrain neurons. Using Parkinson's disease (PD) patient iPSC-derived midbrain cultures, we find that chronic, endogenous accumulation of α-syn directly inhibits autophagosome-lysosome fusion by impairing ykt6-SNAP-29 complexes. In wild-type (WT) cultures, ykt6 depletion caused a near-complete block of autophagic flux, highlighting its critical role for autophagy in human iPSC-derived neurons. In PD, macroautophagy impairment was associated with increased farnesyltransferase (FTase) activity, and FTase inhibitors restored macroautophagic flux through promoting active forms of ykt6 in human cultures, and male and female mice. Our findings indicate that ykt6 mediates cellular clearance by coordinating autophagic-lysosomal fusion and hydrolase trafficking, and that macroautophagy impairment in PD can be rescued by FTase inhibitors.

SIGNIFICANCE STATEMENTThe pathogenic mechanisms that lead to the death of neurons in Parkinson's disease (PD) and Dementia with Lewy bodies (LBD) are currently unknown. Furthermore, disease modifying treatments for these diseases do not exist. Our study indicates that a cellular clearance pathway termed autophagy is impaired in patient-derived culture models of PD andin vivo. We identified a novel druggable target, a soluble NSF attachment protein receptor (SNARE) protein called ykt6, that rescues autophagyin vitroandin vivoupon blocking its farnesylation. Our work suggests that farnesyltransferase (FTase) inhibitors may be useful therapies for PD and DLB through enhancing autophagic-lysosomal clearance of aggregated proteins.
MINIMIZED VOLTAGE DROP RECTIFIER CIRCUIT USING PIEZOELECTRIC TRANSDUCER FOR ENERGY HARVESTING
Authors:   Material Synthesis & Characterizations (MSC) Lab-Electronics Division, Department of Physics, Fatima Jinnah Women University (FJWU), The Mall, Rawalpindi-Pakistan, ANWAR S. , BAKHT K. ,   Department of Electronic Engineering, Fatima Jinnah Women University (FJWU), The Mall, Rawalpindi-Pakistan., ALI A. ,   Department of Electrical Engineering, Sukkur IBA University, Sukker-Pakistan, GUL M. T. ,   Sharif College of Engineering and Technology, Lahore-Pakistan., KHAN M. Y. A. ,   Department of Electrical Engineering, Gomal University, D I Khan-Pakistan, DIN A. U. ,   Material Synthesis & Characterizations (MSC) Lab-Electronics Division, Department of Physics, Fatima Jinnah Women University (FJWU), The Mall, Rawalpindi-Pakistan
Published: February 2023

Piezoelectric systems produce an AC voltage signal at the output and to utilize this voltage, It is required to convert this AC signal into DC with the assistance of the rectifying circuit. The aim of this research is to minimize the voltage drop VD of the conventional diode by designing a diode circuit with the help of MOSFETs to be used in the rectifier. In conventional full bridge rectifier (Con-FBR) the power losses are very high because of diodes drop VD. To minimize these losses the Con-FBR circuit is altered with the employment of both n-type and p-type MOSFETs to be operated in the deep triode (ohmic) region while blocking the reverse leakage which results in reducing the threshold voltage VTH to few mV. Both positive and negative cycles are availed and investigated to extract the maximum output voltage. It is simulated in NI-Multisim (version 14.0) and is implemented using discrete components. The results show that the bridge rectifier using proposed low diode drop configuration has a better power conversion efficiency and can extract power ‘4’ four times more than the Con-FBR.
Nickel-titanium based nanocomposites for orthopedic applications: the effects of reinforcements
Authors:   Research Scholar, Department of Mechanical Engineering, Rajkiya Engineering College, Mainpuri, India, Singh R. , Sharma A. K. ,   Associate Professor, Department of Mechanical Engineering, Rajkiya Engineering College, Mainpuri, India, Sharma A. K. ,   Assistant Professor, Department of Mechanical Engineering, Institute of Engineering and Technology, Lucknow, India
Published: February 2023

Owing to better mechanical properties and shape memory effect, the nickel-titanium (NiTi) alloy is a favorable material for orthopedic implants. However, low wear resistance and limited biocompatibility of NiTi can be enhanced by nano-sized reinforcements. Several NiTi-based nanocomposites are developed using nano-sized ceramic reinforcements. Similarly, bioceramic (i.e., HAp) reinforced NiTi nanocomposites are also developed to improve their bioactive properties. However, these nanocomposites show high interconnected pores that severely affect their mechanical strength, corrosion resistance, and biocompatibility. Therefore, some further improvements are required to balance the mechanical and biological properties of NiTi-based nanocomposites. This paper provides a better understanding of NiTi-based nanocomposites developed for orthopedic applications and the resultant effects of nano-sized reinforcements on mechanical, wear, corrosion, biocompatible and bioactive properties. Besides, the synthesis of NiTi nanocomposites using the powder metallurgy process and the effects of process parameters on the nanocomposite properties were also discussed.
Bionspired slippery surfaces by cluster-like ZnO@Co3O4 and its anti-corrosion performance
Authors:   School of Mechanical Engineering, Changchun University of Technology, Changchun, China,130012, Gao S. , Li X. D. ,   School of Mechanical Engineering, Changchun University of Technology, Changchun, China,130012, Zhang M. ,   School of Mechanical Engineering, Changchun University of Technology, Changchun, China,130012
Published: February 2023

Herein, the super slippery surface composed of cluster-like ZnO@Co3O4 was prepared on the surface of Al alloy by a hydrothermal method. The morphology and composition of the film were characterized by SEM, XRD and XPS. In addition, electrochemical measurement results show that the impedance modulus at low frequency of cluster-like ZnO@Co3O4 SLIPS coatings was 6 orders of magnitude higher than that of the blank sample, and still 3 orders of magnitude towered over even after 28 days of immersion, which proves that the good storage capacity and long-term corrosion resistance.
Nanostructure of carbonated hydroxyapatite precipitation extracted from pearl shells (Pinctada maxima) by pH treatment
Authors:   Department of Physics, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia, Anggraini R. , Sari M. ,   Department of Physics, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia, Aminatun  ,   Department of Physics, Universitas Airlangga, Surabaya 60115, Indonesia, Suciati T. ,   Department of Pharmaceutics, Institut Teknologi Bandung, Bandung 40116, Indonesia, Dahlan K. ,   Department of Physics, Institut Pertanian Bogor, Bogor 16680, Indonesia, Yusuf Y. ,   Department of Physics, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
Published: February 2023

Carbonated hydroxyapatite (CHA) was successfully synthesized from pearl shells (Pinctada maxima) using the precipitation method with pH treatment variation. Based on the X-ray diffractometer (XRD) results, pH treatment caused the crystallographic properties of CHA to decrease. The Fourier transform infrared spectroscopy (FTIR) data showed the characteristics of B-type CHA. The energy dispersive X-Ray spectroscopy (EDS) analysis showed that CHA synthesized with a pH of 10 had the most significant carbonate content of 6.3 wt%. Based on the transmission electron microscopy (TEM) analysis, the morphology of CHA with a pH of 10 was the most agglomerated compared to the other samples.
Recém-nascidos prematuros e a alta hospitalar: uma revisão integrativa sobre a atuação da enfermagem
Authors: Schmidt Kayna Trombini , Bessa Jacqueline Botura , Rodrigues Bruna Caroline , Arenas Mônica Mauad , Corrêa Darci Aparecida Martins , Higarashi Ieda Harumi
Published: February 2023

O objetivo desta pesquisa foi investigar evidências sobre as ações de enfermagem utilizadas junto às mães de prematuros internados em Unidades Neonatais no preparo da alta e apontar dificuldades advindas da prática. As bases Lilacs, Bdenf, Medline e a biblioteca eletrônica SCIELO foram utilizadas para a seleção de sete artigos entre 2004 e 2010. As principais ações de enfermagem citadas foram: apoio ao aleitamento materno; cuidados de higiene; orientações sobre ordenha e vacinação; estímulo ao vínculo afetivo e acompanhamento ambulatorial após a alta. Três artigos relataram dificuldades encontradas sendo elas: intervenção dos pais nos cuidados; problemas de relacionamento entre família e profissionais; e medo dos pais em realizar os cuidados. Concluímos ser necessária a padronização das informações fornecidas pelas equipes de saúde nas Unidades Neonatais, bem como uma sistematização do preparo dos pais para a alta.
Comunicação enfermeiro-paciente no pré-operatório: revisão integrativa
Authors: Mafetoni Reginaldo Roque , Higa Rosângela , Bellini Nara Regina
Published: February 2023

O objetivo deste estudo foi identificar as práticas de comunicação do enfermeiro no processo de orientação ao paciente no período pré-operatório. Uma revisão integrativa da literatura resultou na análise de 14 artigos. Sete estudos descreveram a comunicação satisfatória por meio de orientações, diálogo, reuniões, uso de manuais, painéis e outros. Na pediatria, arteterapia e a utilização dos brinquedos foram intervenções eficazes. Seis artigos descreveram insatisfação devido à orientações impositivas, uso de linguagem técnica, a falta de individualidade com o paciente ou apontaram a falta de informação, mostrando que os profissionais tendem a ritualizar as suas funções em instituições onde não há atenção para esta questão. O enfermeiro desempenha um papel importante no cuidado do paciente, sendo a comunicação uma forma relevante de interação, que precisa ser revista e melhorada regularmente.