bluuebunny/crossref_metadata_2025 huggingface dataset:
A mixture of Iranian probiotics had anti-inflammatory and antioxidative effects in oxidative injuries induced by cadmium in liver and blood parameters
Authors: kohan Arezu , Keshtmand Zahra
Published: July 2022

Background: Cadmium (Cd) causes significant oxidative stress, which can lead to major clinical complications and tissue destruction. In this study, the antioxidant and anti-inflammatory effects of a mixture of Iranian probiotic strains were evaluated in Cd-exposed rats. Method and Materials: Twenty-one adult male Wistar rats were randomized into three groups of seven rats. Group one included the control group; group two consisted of Cd-treated (3 mg/kg, a single dose) animals, and group three included the rats treated with Cd + probiotic (Cd+Pro) for 30 days. Histological changes were assessed using hematoxylin and eosin staining, as well as Masson’s trichrome staining. The qRT-PCR method was used for evaluating pro-inflammatory genes’ expression. Liver biomarkers and biochemical enzymes were measured using commercial kits, and hematological parameters were determined in both Cd- and the Cd+Pro- treated groups. Results: Histopathological results revealed that the native probiotic mixture improved the function of Cd-treated liver cells, accompanied with the down-regulation of TNF-α and IL-6 genes’ expression in Cd+Pro- treated compared with Cd-treated rats. In addition, Cd+Pro- treated rats displayed lower production of lipid peroxides, lower levels of hepatic toxicity biomarkers, and greater antioxidant capacity compared to Cd-treated animals. Conclusion: Iranian native probiotics showed antioxidant and anti-inflammatory properties, and it is suggested to investigate their health benefits in animal studies in future.
Hydrocolloids and partially defatted cake on encapsulation of baru oil (Dipteryx alata Vogel): a study on emulsion, particle, and oxidative stability
Authors: Lima Dyana Carla , Noguera Nathan Hargreaves , Granados Angela del Pilar Flores , Rodrigues Rodney Alexandre Ferreira
Published: July 2022

The baru (Dipteryx alata Vogel) is a fruit of the Brazilian Cerrado, composed of a pleasant-tasting almond with a high oil content. The consumption of vegetable oils is suggested by the World Health Organization, but vegetable oils lack protection when extracted from their food matrix. Thus, the hydrocolloids Arabic gum (AG) and maltodextrin (MD) as well as the partially defatted cake (PDC), a co-product of the baru cold-pressed oil, were used to produce baru oil microparticles by spray drying. Fatty acid profile, emulsion stability, microparticle quality, and oxidative stability were evaluated. Baru oil is rich in omega-9 (47.3%). AG/MD (25% maltodextrin) showed better emulsion stability after 1h of preparation, higher zeta potential (-28.87 mV ± 0.026) and encapsulation efficiency (76.72% ± 0.002), and lower peroxide content after 4 weeks at 60°C (28.38 meq/kg). The addition of PDC improved the efficiency parameters in relation to the standard formulation (AG). The replacement of 25% of AG by MD improved the emulsion and microparticles' characteristics and better protected the baru oil against oxidation. Through a well-known technique, this study found technological use for a co-product of the extraction of baru oil and made good use of maltodextrin, a hydrocolloid with a lower relative cost.
Convergence of Neuromarketing Technologies in Modern Conditions of Economic Development
Authors: Sadchenko Olena V.
Published: July 2022

During periods of socio-economic, innovative-ecological and political transformations, the social system may not perform its functions, which will lead to a disruption of the sustainable of public life. The economy of transformation is a part of the societal system that contributes to the change of the client himself and his needs and demands. These processes are manifested in ignoring generally recognized economic and environmental values, political, ideological, cultural and moral. The development of technologies in the past was usually determined over long periods by some one discovery or progress in one area, today with the development of digitalization, the universal introduction of information technologies in various spheres of life: services, production and economic activities, education, culture, etc. etc., there is a convergence of economics, management and marketing in a short time frame. This phenomenon is caused by the rapid development of information and communication technologies, microelectronics, microbiology, simulations, nanomanipulations, “strong” artificial intelligence in most countries of the world. We believe that the convergence of information technology, biotechnology, nanotechnology and cognitive science is especially significant. And in such modern convergent conditions, neuromarketing technologies are rapidly developing at a new level. The development and application of neuromarketing technologies deserve study so that there is no further ethical "shock" and coercion to buy at an unconscious level. Such technologies were used earlier in various fields of economic activity, in psychology and in solving other issues. Neuromarketing technologies are changing ideas about the environment: nature, man, mind. It is difficult to describe the results of such transformation processes, where all aspects of human life are subject to change.
DEVELOPMENT OF MODEL-DRIVEN DECISION SUPPORT SYSTEM TO SCHEDULE UNDERWATER HULL CLEANING
Authors:   Department of Marine Engineering Institut Teknologi Sepuluh Nopember Kampus ITS Sukolilo, Dinariyana AAB
Published: July 2022

Maritime industries are constantly searching for a method to enhance ship efficiency, with increasing concern about the environmental impact and rising fuel prices. Marine biofouling is one of the factors that increase ship fuel consumption. However, removing the fouling of the ship requires effort for hull maintenance. Due to the trade-off between conducting maintenance and performance degradation, this study presents the development of a Model-Driven Decision Support System (MD-DSS) to predict the optimum time for underwater hull cleaning for biofouling management. Five stages (sub-models) are employed to develop a DSS, namely: ship resistance estimation, estimation of additional resistance due to biofouling, an iterative-based method for determining the best time to conduct the hull cleaning, and an analysis report. The implemented algorithm was validated by comparing its result with a manually scheduled maintenance date. The DSS is able to determine the best time (date) for maintenance in all given scenarios. By giving two scenarios of different maintenance costs and different fuel prices, the optimisation results produce the same number of maintenances. Within 60 months, four to five hull cleanings are required. It is also found that when the optimal number of maintenances is known, then increasing this number will not have any impact on reducing the hull cleaning costs because the reduction in fouling does not significantly reduce the costs incurred for maintenance. During several trials of the DSS, it is shown that the system can generate maintenance schedules for different time intervals of ship operation within an acceptable time. It takes approximately 52 minutes, 12 minutes, and 5 minutes consecutively to determine the maintenance schedules for ship operation intervals of 5 years, 2.5 years, and 1 year.
Implementasi Fitur Sinkronisasi Basis Data Pada Aplikasi Monitoring Keuangan Pada Wilayah Dengan Keterbatasan Jaringan Internet
Authors: Setiawan Aldi , Sebastian Danny , Adi Nugraha Kristian
Published: July 2022

Petani tembakau pada Jawa Tengah sering melakukan hubungan komersial terhadap banyak pihak. Salah satu dari aksi proses tersebut adalah proses hutang piutang antara petani dengan pedagang. Kesulitan yang muncul dari proses tersebut adalah ketika mencatat data hutang setiap harinya. Seringkali petani pada daerah tersebut masih menggunakan kertas sebagai media untuk menyimpan data hutang. Tentunya hal ini dapat menjadi masalah ketika kertas tersebut hilang dan data hutang yang dimiliki juga hilang. Sehingga diusulkan untuk membuat aplikasi pencatatan hutang pada perangkat bergerak sehingga mudah dibawa dan data yang disimpan tidak mudah hilang. Tetapi muncul permasalahan baru yaitu ketika perangkat bergerak tidak terhubung dengas jaringan internet apakah data hutang masih tetap dapat disimpan melihat bahwa daerah tempat petani berada tidak memiliki jaringan internet yang memadai.

Berdasarkan pada masalah yang dihadapi, maka diusulkan untuk membuat algoritma sinkronisasi yang dapat menangani ketika perangkat bergerak tidak terhubung dengan jaringan internet. Data tersebut akan dilakukan sinkronisasi pada aplikasi situs web yang dibuat, sehingga data yang dimasukkan oleh petani ketika tidak terhubung dengan jaringan internet dapat tersimpan dengan baik tanpa takut kehilangan data hutang tersebut.

Pengujian dilakukan dengan menggunakan pengujian kotak putih dan pengujian aktual. Untuk pengujian kotak putih yang diujikan pada algoritma yang telah dibuat, didapatkan hasil bahwa algoritma yang dibuat memiliki tingkat resiko yang rendah dan probabilitas perbaikan sebesar 5 persen. Untuk pengujian aktual yang dilakukan, berdasarkan hasil yang didapat tiap skenario pengujian dapat teruji dengan baik dan menghasilkan hasil yang baik. Sehingga dapat disimpulkan bahwa algoritma yang telah dibuat layak untuk diterapkan pada perangkat bergerak.
Fingerprints of quantum criticality in locally resolved transport
Authors: Huang Xiaoyang , Lucas Andrew
Published: July 2022

Understanding electrical transport in strange metals, including the seeming universality of Planckian T-linear resistivity, remains a longstanding challenge in condensed matter physics. We propose that local imaging techniques, such as nitrogen vacancy center magnetometry, can locally identify signatures of quantum critical response which are invisible in measurements of a bulk electrical resistivity. As an illustrative example, we use a minimal holographic model for a strange metal in two spatial dimensions to predict how electrical current will flow in regimes dominated by quantum critical dynamics on the Planckian length scale. We describe the crossover between quantum critical transport and hydrodynamic transport (including Ohmic regimes), both in charge neutral and finite density systems. We compare our holographic predictions to experiments on charge neutral graphene, finding quantitative agreement with available data; we suggest further experiments which may determine the relevance of our framework to transport on Planckian scales in this material. More broadly, we propose that locally imaged transport be used to test the universality (or lack thereof) of microscopic dynamics in the diverse set of quantum materials exhibiting T-linear resistivity.
Personnel solutions for clinical risk management in hospitals: Evidence from the Czech Republic
Authors: Prokešová Radka
Published: July 2022

Clinical risk management (CRM) is a specific form of risk management used in hospitals that focuses directly on clinical processes and indirectly on patient-related processes as well as on individuals, including their potential to make mistakes. The aim of this study was to describe and analyze the central CRM coordination in hospitals using the Czech version of the CRM monitoring tool developed for hospital environments. Quantitative research consisted of collecting and evaluating data using statistical methods. The research set consisted of responses from 53 participating hospitals recorded in the Czech version of the CRM monitoring tool. The results did not identify statistically significant differences among types of hospitals in terms of whether or not a person responsible for the central coordination of clinical risk management activities is designated in them. According to the findings, this fact does not affect the type of hospital or whether it is a public or private hospital. The paper also show that most hospitals have one person responsible for coordinating CRM who is often also employed as the hospital’s quality manager. In faculty hospitals, the person responsible for CRM is often a subordinate to the medical director or the deputy for medical care, etc. In city and other hospitals, they are usually directly subordinate to the director. The study showed that the person responsible for clinical risk management most often holds the quality manager position in hospitals. AcknowledgmentThis contribution was supported by the Faculty of Health and Social Sciences of the University of South Bohemia in České Budějovice as part of an individual internal research project of the ZSF USB entitled “Utilization of Clinical Risk Management in the Environment of Czech Hospitals” funded by the ZSF USB RVO.
DETERMINAÇÃO DE ETIL-GLICURONÍDEO E ETIL-SULFATO EM SANGUE POR UPLC-MS/MS: APLICAÇÃO CLÍNICA EM VÍTIMAS DE TRAUMA
Authors: Ott Isabela , Tegner Mariane , Gerbase Fernando , Sagrilo Octaviano , Linden Rafael , Antunes Marina
Published: July 2022

DETERMINATION OF ETHYL-GLUCURONIDE AND ETHYL-SULFATE IN BLOOD BY UPLC-MS/MS: CLINICAL APPLICATION IN TRAUMA VICTIMS. We developed a UPLC-MS/MS method for the quantification of the ethanol metabolites ethyl-glucuronide (EtG) and ethyl-sulfate (EtS) in blood samples. Sample preparation was a protein precipitation with acetonitrile 0.1% formic acid containing internal standards (IS) 0.5 µg mL-1 EtG-D5 and EtS-D5. Chromatographic separation was performed in a fluoro-phenyl column, mobile phases were 0.1% formic acid in water (A) and acetonitrile (B) in gradient elution from 5% B to 70% B, with 10 min run time. Ionization was performed with electrospray source at 550 °C in negative mode, quantification mass transitions of m/z EtG 221- 75, EtS 125- 80.1, EtS-D5 130- 79.9, and EtG-D5 226- 75.1. The method was linear from 0.1 to 18 µg mL-1 for EtG and 0.02 to 6 µg mL-1 for EtS, specific, with no interfering peaks during the blank samples analyses. The method was precise and accurate, the matrix effect was compensated with the IS (-12% a + 6.1%). EtG and EtS were analyzed in 28 blood samples from trauma patients with positive alcoholaemia. The concentrations of EtG and EtS ranged from 0.25 to 14.11 µg mL-1 and 0.13 to 5.53 µg mL-1, with high correlation with ethanol concentrations, r=0.739 and r=0.817 (p <0,001), respectively
Ham ve Epoksi Reçine Kaplı Teknik Elyaf Kullanımının Yapı Elemanı Performansına Etkisi
Authors: KURBAN Mutlu , BABAARSLAN Osman , ÇAĞATAY İsmail Hakkı
Published: July 2022

Tekstil takviyeli betonlar (TTB) kullanımı giderek yaygınlaşan sandviç paneller, çatı konstrüksiyonları, yürüyüş köprüleri ve bahçe mobilyaları gibi kullanım alanları olan yenilikçi yapı malzemeleridir. TTB’ler ince tanecikli agregadan üretilen beton ve yüksek çekme dayanımına sahip korozyon riski taşımayan tekstil yüzeylerinden oluşan kompozit yapılardır. Çalışmada beton takviyesinde yaygın olarak kullanılan alkali dayanımlı cam, bazalt ve karbon filamentler ham ve epoksi reçine kaplı olarak iki farklı yüzey halinde ve üç farklı konumda kullanılmıştır. Takviyesiz numune ile birlikte farklı parametrelerde 37 adet numune üretilmiş ve numunelere eğilme deneyi uygulanmıştır. Eğilme deneyi sonucunda en fazla değer karbon filamentli numunelerde elde edilirken en düşük değer ise bazalt filamentli numunelerde elde edilmiştir. Epoksi reçine kullanımının ham filament kullanımına göre eğilme dayanımına katkısı ortalama olarak alkali dayanımlı cam filamentte %63, bazalt filamentte %71, karbon filamentte ise %127 olmuştur.
Dematerialization of Art: Concepts and Its Traces in Contemporary Indian Art
Authors:   Research Scholar (UGC-JRF), Department of Fine Arts, Aligarh Muslim University, Aligarh
Published: July 2022

This paper explores the concept of “dematerialization” which was introduced by Lucy Lippard and John Chandler in their work on conceptual art that emerged in the 1960s. Dematerialization stands for the dominance of ideas linked with intelligence on materiality linked with sensory perception. So, dematerialization is a kind of process in which ideas take the lead and become primary, and materiality loses its traditional status and becomes secondary. The notion of dematerialization can be reconsidered on these grounds. First of all, the core of the work is the idea or concept, no material form. Secondly, the core of the artwork is not confined to what the viewer “looks at” as an art object as a final product. Thus, the idea permits the process. The concept of dematerialization gave a new vision to Indian artists to explore their feelings and thoughts through concepts and ideas with readymade objects. By interpreting conceptual art and dematerialization, the author concludes that these tendencies share significant similarities, and that is a beneficial and innovative sight in the contemporary art scene in India.
Micro RNAs as Emerging Therapeutic Targets in Liver Diseases
Authors: Jain Subheet Kumar , Latief Uzma , Tung Gurleen Kaur , Per Tasir Sharief , Kaur Manjot , Thakur Shubham , Singh Harjeet
Published: July 2022

MicroRNAs (MiRNAs) are endogenous non-coding small RNA molecules that regulate
gene expression in plants, animals and some viruses. Both normal and pathological liver processes are
regulated by miRNAs. Recent research indicated that miRNAs have been implicated in liver diseases
caused by viral hepatitis (Hepatitis B and Hepatitis C), metabolic problems, alcohol and drug abuse.
Because altered miRNA expression is linked to liver metabolic dysregulation, liver damage, liver fibrosis,
and tumour growth, miRNAs are promising therapeutic targets for the detection and treatment
of liver diseases. In this review, we summarise the current knowledge about the role of microRNAs in
acute and chronic liver diseases, including hepatocellular carcinoma. We cover the miRNA-based
therapy for liver disorders as well as the use of miRNAs as biomarkers for early diagnosis, prognosis
and assessment of liver diseases. The investigation of miRNAs in liver diseases will provide a better
understanding of the pathogeneses, identification of biomarkers and therapeutic targets for liver diseases
in the future.
Realizar a modernidade: Pesar o legado modernista na prosa contemporânea de língua portuguesa
Authors: Bucaioni Marco
Published: July 2022

No centenário da Semana de Arte Moderna de São Paulo e do lançamento em volume do Ulysses de James Joyce, este artigo visa animar uma reflexão sobre o legado do(s) modernismo(s) no panorama contemporâneo das literaturas de língua portuguesa, incidindo no género do romance, consagrado cada vez mais no último século como género central da modernidade literária mundial. O objectivo desta reflexão será questionar e eventualmente redefinir o conceito de modernidade literária aplicado à prosa em português, considerando as linhas de força que surgem das experiências modernistas nacionais e internacionais. As perguntas cen-trais deste artigo serão: como e em que medida a contemporânea prosa longa em português é devedora dos movimentos modernistas português e brasileiro? Até que ponto está ligada a um eventual modernismo in-ternacional que, irradiando das línguas centrais do Sistema Literário Mundial, iria dialogar separadamente com as várias (semi-)periferias? E, por fim: qual é a voz distintiva da modernidade literária na prosa longa em português – se é que há uma – e de que ingredientes (dispositivos, formas) se compõe?
James Joyce and Mario Vargas Llosa: Meeting on the Margins
Authors: Goodridge Frankie
Published: July 2022

This study critiques two mainstream novelists known for their localities of Ireland and Peru as well as their long sojourns and major works set abroad. It argues that, contrary to popular, recent opinion regarding these seemingly abstruse and possibly elitist figures, both directly engage with the marginal aspects of both society and nature in intriguing and sensitive ways. Furthermore, these margins— as developed through consideration of a series of eclectic philosophical thinkers including Michel Foucault, Margarita Serje and Timothy Morton— are where the authors meet: where their writing converges. Comparison between the two hinges upon a philosophical understanding of these very margins. The writers, complex and irreducible, also seesaw between the terms that are almost always used to describe them: “modernist” and “realist”, “humorous” and “serious”, “local” and “global”, terms which I believe require renewed and nuanced consideration and recasting in the light of this comparison. Through a combination of close-readings and integrated theoretical analysis, I argue that Joyce and Vargas Llosa meet on the margins of: modern society, the environment, and their political contexts, producing some of the most timeless works of twentieth-century fiction as a result.
COVID-19 Cases Among Congregate Care Facility Staff by Neighborhood of Residence and Social and Structural Determinants: Observational Study
Authors: Ma Huiting , Yiu Kristy C Y , Baral Stefan D , Fahim Christine , Moloney Gary , Darvin Dariya , Landsman David , Chan Adrienne K , Straus Sharon , Mishra Sharmistha
Published: July 2022

Background

Disproportionate risks of COVID-19 in congregate care facilities including long-term care homes, retirement homes, and shelters both affect and are affected by SARS-CoV-2 infections among facility staff. In cities across Canada, there has been a consistent trend of geographic clustering of COVID-19 cases. However, there is limited information on how COVID-19 among facility staff reflects urban neighborhood disparities, particularly when stratified by the social and structural determinants of community-level transmission.

Objective

This study aimed to compare the concentration of cumulative cases by geography and social and structural determinants across 3 mutually exclusive subgroups in the Greater Toronto Area (population: 7.1 million): community, facility staff, and health care workers (HCWs) in other settings.

Methods

We conducted a retrospective, observational study using surveillance data on laboratory-confirmed COVID-19 cases (January 23 to December 13, 2020; prior to vaccination rollout). We derived neighborhood-level social and structural determinants from census data and generated Lorenz curves, Gini coefficients, and the Hoover index to visualize and quantify inequalities in cases.

Results

The hardest-hit neighborhoods (comprising 20% of the population) accounted for 53.87% (44,937/83,419) of community cases, 48.59% (2356/4849) of facility staff cases, and 42.34% (1669/3942) of other HCW cases. Compared with other HCWs, cases among facility staff reflected the distribution of community cases more closely. Cases among facility staff reflected greater social and structural inequalities (larger Gini coefficients) than those of other HCWs across all determinants. Facility staff cases were also more likely than community cases to be concentrated in lower-income neighborhoods (Gini 0.24, 95% CI 0.15-0.38 vs 0.14, 95% CI 0.08-0.21) with a higher household density (Gini 0.23, 95% CI 0.17-0.29 vs 0.17, 95% CI 0.12-0.22) and with a greater proportion working in other essential services (Gini 0.29, 95% CI 0.21-0.40 vs 0.22, 95% CI 0.17-0.28).

Conclusions

COVID-19 cases among facility staff largely reflect neighborhood-level heterogeneity and disparities, even more so than cases among other HCWs. The findings signal the importance of interventions prioritized and tailored to the home geographies of facility staff in addition to workplace measures, including prioritization and reach of vaccination at home (neighborhood level) and at work.
Virtual Reality–Based Rehabilitation as a Feasible and Engaging Tool for the Management of Chronic Poststroke Upper-Extremity Function Recovery: Randomized Controlled Trial
Authors: Hernandez Alejandro , Bubyr Liudmila , Archambault Philippe S , Higgins Johanne , Levin Mindy F , Kairy Dahlia
Published: July 2022

Background

A growing number of stroke survivors are left with little to no rehabilitation services upon discharge from stroke rehabilitation, although arm deficits may persist or develop from disuse once rehabilitation services have ceased. Virtual reality (VR)–based rehabilitation, combined with new technologies such as telerehabilitation, including serious games using VR environments that encourage users to practice functional movements from home with minimal supervision, may have an important role to play in optimizing and maintaining upper extremity (UE) function.

Objective

The primary objective of this study is to determine the extent to which a 1-month intervention using a VR-based serious game is effective in improving UE function compared with an evidence-based home exercise program. A secondary objective is to assess the feasibility of implementing the intervention for chronic stroke rehabilitation in participants’ homes.

Methods

A total of 51 chronic stroke participants were randomized to treatment (n=26, 51%; Jintronix system) or standard care (n=25, 49%; standardized Graded Repetitive Arm Supplementary Program kit home program) groups. The participants were evaluated at baseline (before), immediately after the intervention (after), and at follow-up (4 weeks). The primary outcome measure was the Fugl-Meyer Assessment for UE (FMA-UE). Secondary outcome measures included the Stroke Impact Scale and an abridged version of the Motor Activity Log-14. Self-reported number of sessions was logged for the standard care group.

Results

No statistically significant differences between groups were found across measures. Overall time effects were found for the FMA-UE (P=.045), specifically between preintervention and postintervention time points for both groups (P=.03). A total of 9 participants in the treatment group reached or surpassed the minimal clinically important difference in scores for the FMA-UE, with 7 (78%) of them having baseline low or moderate arm function, compared with 3 (33%) participants in the standard care group. Furthermore, 56% (9/16) of the participants in the treatment group who actively engaged with the system reached the minimal clinically important difference for the FMA-UE, compared with none for the 0% (0/10) less-active participants.

Conclusions

These findings suggest that UE training for chronic stroke survivors using virtual rehabilitation in their home may be as effective as a gold standard home exercise program and that those who used the system the most achieved the greatest improvement in UE function, indicating its relevance to being included as part of ongoing rehabilitation services.

Trial Registration

ClinicalTrials.gov NCT02491203; https://clinicaltrials.gov/ct2/show/NCT02491203

International Registered Report Identifier (IRRID)

RR2-10.1016/j.cct.2015.12.006
Key Stakeholder Barriers and Facilitators to Implementing Remote Monitoring Technologies: Protocol for a Mixed Methods Analysis
Authors: Iqbal Fahad Mujtaba , Joshi Meera , Khan Sadia , Wright Mike , Ashrafian Hutan , Darzi Ara
Published: July 2022

Background

The implementation of novel digital solutions within the National Health Service has historically been challenging. Since the start of the COVID-19 pandemic, there has been a greater push for digitization and for operating remote monitoring solutions. However, the implementation and widespread adoption of this type of innovation have been poorly studied.

Objective

We aim to investigate key stakeholder barriers and facilitators to implementing remote monitoring solutions to identify factors that could affect successful adoption.

Methods

A mixed methods approach will be implemented. Semistructured interviews will be conducted with high-level stakeholders from industry and academia and health care providers who have played an instrumental role in, and have prior experience with, implementing digital solutions, alongside the use of an adapted version of the Technology Acceptance Model questionnaire.

Results

Enrollment is currently underway, having started in February 2022. It is anticipated to end in July 2022, with data analysis scheduled to commence in August 2022.

Conclusions

The results of our study may highlight key barriers and facilitators to implementing digital remote monitoring solutions, thereby allowing for improved widespread adoption within the National Health Service in the future.

Trial Registration

ClinicalTrials.gov NCT05321004; https://clinicaltrials.gov/ct2/show/NCT05321004
Digital Technologies for Health Promotion and Disease Prevention in Older People: Protocol for a Scoping Review (Preprint)
Authors: De Santis Karina Karolina , Mergenthal Lea , Christianson Lara , Zeeb Hajo
Published: July 2022

BACKGROUND

Digital technologies could contribute to health promotion and disease prevention. It is unclear if and how such digital technologies address the health needs of older people in nonclinical settings (ie, daily life).

OBJECTIVE

This study aims to identify digital technologies for health promotion and disease prevention that target the needs of older people in nonclinical settings by performing a scoping review of the published literature. The scoping review is guided by the framework of Arksey and O’Malley.

METHODS

Our scoping review follows the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. The information sources are bibliographic databases (MEDLINE, PsycINFO, CINAHL, and SCOPUS) and bibliographies of any included systematic reviews. Manual searches for additional studies will be performed in Google Scholar and most relevant journals. The electronic search strategy was developed in collaboration with a librarian who performed the search for studies on digital technologies for health promotion and disease prevention targeting the needs of older people. Study selection and data coding will be performed independently by 2 authors. Consensus will be reached by discussion. Eligibility is based on the PCC (Population, Concept, and Context) criteria as follows: (1) older people (population); (2) any digital (health) technology, such as websites, smartphone apps, or wearables (concept); and (3) health promotion and disease prevention in nonclinical (daily life, home, or community) settings (context). Primary studies with any design or reviews with a systematic methodology published in peer-reviewed academic journals will be included. Data items will address study designs, PCC criteria, benefits or barriers related to digital technology use by older people, and evidence gaps. Data will be synthesized using descriptive statistics or narratively described by identifying common themes. Quality appraisal will be performed for any included systematic reviews, using a validated instrument for this study type (A Measurement Tool to Assess Systematic Reviews, version 2 [AMSTAR2]).

RESULTS

Following preliminary literature searches to test and calibrate the search syntax, the electronic literature search was performed in March 2022 and manual searches were completed in June 2022. Study selection based on titles and abstracts was completed in July 2022, and the full-text screen was initiated in July 2022.

CONCLUSIONS

Our scoping review will identify the types of digital technologies, health targets in the context of health promotion and disease prevention, and health benefits or barriers associated with the use of such technologies for older people in nonclinical settings. This knowledge could guide further research on how digital technologies can support healthy aging.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/37729
Improving the Health and Well-Being of Individuals by Addressing Social, Economic, and Health Inequities (Healthy Eating Active Living): Protocol for a Cohort Study (Preprint)
Authors: Joshi Ashish , Mohan Surapaneni Krishna , Pandya Apurva Kumar , Grover Ashoo , Kaur Harpreet , Gupta Mansi , Aurora Heemanshu , Bhatt Ashruti
Published: July 2022

BACKGROUND

Health inequity is interlinked with the good health and well-being of an individual. Health inequity can be due to various socioeconomic factors like income levels or social status. Digital health interventions have the potential to reduce the existing health inequities.

OBJECTIVE

This study aims to identify determinants of social, economic, and health inequity in diverse settings to enhance healthy eating and active living. It further aims to design and develop a digital health intervention HEAL (Healthy Eating Active Living) that incorporates a human-centered design framework in order to improve healthy eating and active living among rural and urban population groups in Chennai, Tamil Nadu, India.

METHODS

A prospective, 3-year cohort study will be conducted. This study aims to recruit 6350 individuals across rural and urban settings of Chennai. A total of 11 sites have been selected for participation in the study. Data on sociodemographic characteristics; economic inequity; HEAL profile; depression, anxiety, and stress; well-being; sources of health information; perceived access to health care; health literacy; navigation of health literacy; and satisfaction with the health system will be gathered. This study would help to explore the determinants of social, economic, and health inequity across multiple sites. SAS (version 9.3; SAS Institute Inc) will be used for data analysis, and results will be reported as 95% CI and P values. This study’s findings will guide the design and development of a tailored, human-centered digital health intervention to enhance the health and well-being of Chennai’s population groups.

RESULTS

As of December 2024, the literature review for the development of the intervention has been completed. The recruitment for the baseline data collection will begin shortly, followed by the development of HEAL intervention.

CONCLUSIONS

The proposed study will help in examining the role of the proposed HEAL intervention to enhance the health and well-being of the population groups of Chennai.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/41169
Study of Effective AI Algorithms in Natural Language Processing in Todays Era
Authors: Kulkarni Vaibhav Vijay
Published: July 2022

Abstract: In today’s modern era of technology, text analysis and Natural Language Processing had become crucial in artificial intelligence. Natural language is a specific language which helps machine in reading the text with the help of stimulating the ability of human for understanding a natural language like English or any other language. It consists of a theory-motivated range of computational techniques which can be useful for automatic text analysis and representation of human language. There has been an advancement in state-of-model in recent years but they have become less interpretable. The research paper gives details about the operations and expansion techniques that are used for NLP model predictions in detail and it focuses on recent developments in NLP to look future of NLP related algorithms and techniques. Also, we find out which NLG (Natural Language Generation) evaluation measures is well related
Development of Client-Specific Web Service for Manipulating Real-Time Contextual Data
Authors: K R Dhruva
Published: July 2022

Abstract: The aim of this work was to create a fully functional client-specific solution for accessing real-time context specific data. These kinds of interfaces have been all the buzz in the domain of banking and can help in achieving a faster turn-aroundtime for the queries being asked by the internal users spread all over the globe. These kinds of interfaces provide an effective way to communicate with a user and offer helpful support in a more economical way- saving both time and efforts being spent on accessing real-time data. The application built aims to provide more space for decision making as real-time access is enabled. The study below mainly concentrates on the various techniques used in developing the system for accessing real-time context specific data.
Detection of Diabetic Retinopathy Using Deep Learning
Authors: M R Prof. Bhavya
Published: July 2022

Abstract: Diabetic retinopathy is one of the most dangerous complications of diabetes, leading to permanent blindness if left untreated. One of the major challenges is early detection, which is very important for the success of treatment. Unfortunately, accurate identification of the stage of diabetic retinopathy is notoriously tricky and requires expert human interpretation of fundus images. Simplifying the detection step is essential and can help millions of people. Convolutional Neural Networks (CNNs) have been successfully used in many neighboring subjects and for the diagnosis of diabetic retinopathy itself. However, the high cost of large annotated datasets as well as inconsistencies between different clinicians hinders the implementation of these methods. In this paper, we propose an automatic method based on deep learning to detect the stage of diabetic retinopathy using a single human fundus image. In addition, we propose a multi-stage transfer learning approach that uses similar datasets with different labels. The presented method can be used as a screening method for the early detection of diabetic retinopathy with a sensitivity and specificity of 0.99 and is ranked 54 out of 2943 competing methods (quadratic weighted kappa score 0.925466) on the APTOS 2019 Blindness Detection Dataset (13,000 images).
The Role of Officials of the Federation Council of the Federal Assembly of the Russian Federation in Ensuring Parliamentary Procedures
Authors:   Russian Presidential Academy of National Economy and Public Administration, Chervinskaya A.P.
Published: July 2022

Issues of the differentiation of the role of a parliamentarian and an official of the Parliament are considered. The norm of legislation regulating the status of officials of the Federation Council and the State Duma of the Federal Assembly of the Russian Federation is analyzed. Proposals for the possible improvement of the norm of legislation are given.
Extra Perichondrium Patch to Enhance Cartilage Graft during Endoscopic Cartilage Myringoplasty
Authors: Wang Bing , Zhang Jin , Yang Qimei , Liu Hui , Xu Min , Zhang Wen
Published: July 2022

Abstract Objectives The aim of this study was to evaluate whether adding
an extra perichondrium patch to enhance the cartilage graft during
endoscopic myringoplasty can improve the healing rate and post-operative
hearing of patients with poor prognostic factors (eustachian tube
dysfunction, large perforations, subtotal perforations and marginal
perforations). Methods This retrospective study analyzed a total of 80
patients (40 females and 40 males, median age of 40.55 years) who had
received an extra patch during endoscopic cartilage myringoplasty.
Patients were followed up for six months. Healing rates, complications,
preoperative and postoperative pure-tone average (PTA) and air-bone gap
(ABG) were analyzed. Results At six months follow-up, the healing rate
of tympanic membrane was 100% (80/80). The mean preoperative pure-tone
average (PTA)（43.18± 14.57 dB HL）significantly decreased (27.08±9.36
dB HL) six months after the operation (P=0.002). Similarly, the mean
preoperative ABG（19.05±5.72 dB HL）reduced to（9.36±3.75 dB HL）
(P=0.0019) at sixth month. Major complications were not observed during
follow-up. Conclusions The usage of an extra patch during endoscopic
cartilage myringoplasty for large, subtotal and marginal tympanic
membrane perforations achieved a high healing rate and a statistically
significant hearing gain with low incidence of complications.
Safety of day-case endoscopic sinus surgery in England: An observational study using an administrative dataset
Authors: Navaratnam Annakan , Pendolino Alfonso , Andrews Peter J , Saleh Hesham , Hopkins Claire , randhawa prem , Little Sarah , Day Jamie , Briggs Tim , Gray William
Published: July 2022

Background: As elective surgical services recover from the COVID-19
pandemic a movement towards day-case surgery may reduce waiting lists.
However, evidence is needed to show that day-case surgery is safe for
many ENT operations including endoscopic sinus surgery (ESS). We aimed
to investigate the safety of ESS in England. Methods: This was an
observational, secondary analysis of administrative data. Participants
were all patients in England undergoing elective ESS procedure aged ≥ 17
years during for the five years from 1st April 2014 to 31st March 2019.
The exposure variable was day-case or overnight stay. The primary
outcome was emergency readmission within 30 days post-discharge.
Results: Data were available for 49,223 patients operated on across 129
NHS hospital trusts. In trusts operating on more than 50 patients in the
study period, rates of day-case surgery varied from 100% to 20.6%.
Rates of day-case surgery increased from 64.0% in 2014/15 to 78.7% in
2018/19. Day-case patients had lower rates of 30-day emergency
readmission (odds ratio 0.71, 95% confidence interval 0.62 to 0.81).
For secondary outcomes measures, there was no evidence of poorer
outcomes for day-case patients. Outcomes for patients operated on in
trusts with ≥80% day-case rates compared to patients operated on in
trusts with <50% rates of day-case surgery were similar.
Conclusions: ESS can safely be performed as day-case surgery at current
rates. There is a potential to increase rates of day-case ESS in
England, especially in departments that currently have low rates of
day-case ESS.
Four-Dimensional Magnetic Resonance after Ascending Aorta Replacement and Aortic Valve Repair with HAART 300 Internal Annuloplasty Ring
Authors: Engel Joshua S. , Bharadwaj Sandeep , Elbaz Mohammed , Markl Michael , Allen Bradley D. , Malaisrie S.
Published: July 2022

The hemispherical aortic annuloplasty reconstructive technology (HAART)
is an internal geometric annuloplasty ring designed to restore a natural
elliptical shape to the aortic annulus as part of aortic valve repair.
We present 4D flow hemodynamic analysis before and after implementation
of the HAART ring in patients undergoing ascending aortic replacement.
HAART patients displayed similar or improved flow profiles when compared
to a patient undergoing ascending aortic replacement alone.
Development and characterization of electrochemical sensors based on carbon modified with TiO2 nanoparticles
Authors: Micin Sasa , Malinovic Borislav , Djuricic Tijana
Published: July 2022

The aim of this study is the development and characterization of a
carbon-based electrochemical sensor, modified with TiO2 nanoparticles for
potential application in electroanalytical techniques. The influence of
binder and modifier contents on morphological, physicochemical and
electrochemical characteristics of the electrode material was investigated
in order to determine the optimal ratio of the carbon
material/binder/modifier. Carbon pastes were prepared from mixtures
containing graphite powder, TiO2 nanoparticles and liquid hydrocarbons.
Scanning electron microscopy showed that the electrode material becomes more
compact with the addition and the increase in the binder material content,
while increasing the proportion of TiO2 nanoparticles did not have any
significant effect on the material morphology showing fairly homogeneous
nanoparticle distribution in the graphite electrode material. The test
results indicate that the modified carbon paste with 40 vol.% paraffin oil
(PO) and 6-8 wt.% TiO2 nanoparticles is characterized by the lowest value of
specific resistance. By applying cyclic voltammetry, the most pronounced
degree of reversibility was obtained in relation to the standard reversible
redox system ([Fe (CN)]-3/-4) for the electrode material with 30-40 vol.% PO
and 8-10 wt.% TiO2 nanoparticles. Characterization of the electrode material
based on carbon modified with TiO2 nanoparticles indicated that the optimal
composition contains 40 vol.% PO and 6-8 wt.% TiO2 nanoparticles, which is
important for application in electroanalytical techniques.
Corrosion effects on structural integrity and life of oil rig drill pipes
Authors: Sedmak Aleksandar , Zaidi Radzeya , Vujicic Borivoje , Sarkocevic Zivce , Kirin Snezana , Stamenic Zoran , Djukic Milos , Bakic Gordana
Published: July 2022

Corrosion effects on structural integrity and life of oil rig welded pipes are analysed by experimental, analytical, and numerical methods. Experiments were performed using standard tensile specimens and CT specimens for static loading, Charpy specimens for impact loading, and 3 Point Bending specimens for fatigue crack growth with amplitude loading. In each case new and old pipes were used to evaluate corrosion effects. Results indicated negligible corrosion effects in the case of tensile properties and impact toughness, and strong effects in the case of fracture toughness and especially fatigue crack growth rates, increasing the risk of static failure and reducing significantly structural life. Analytical expressions are used for oil rig pipe structural integrity and life assessment to quantify these effects. Recently introduced risk-based approach is applied to analyse oil rig drill pipe with a corrosion defect treated as a surface crack.
Labial frenectomy: current clinical practice of orthodontists in the United Kingdom
Authors: Ahn John HyunBaek , Newton Tim , Campbell Catherine
Published: July 2022

Objectives

To obtain views of orthodontists in the United Kingdom on frenectomy in terms of its indications and timing and a recommended retention regimen after correction of median diastema.

Materials and Methods

A 14-item online questionnaire was sent to orthodontic specialists for completion. The questionnaire covered demographics and orthodontists' experience and views on frenectomy.

Results

Three hundred and fifty-three orthodontists with various background and experience responded to the survey. Three-quarters of respondents routinely performed a blanche test to aid diagnosis of the abnormal frenum; however, only 15% carried out radiographic investigation. Three-quarters of the orthodontists would consider frenectomy as a part of orthodontic treatment, and variation existed among the clinicians in terms of its timing. Frenectomy without orthodontic treatment was not preferred. There was much variation in the retention regimen after diastema closure regardless of frenectomy.

Conclusions

Complete consensus among the orthodontists was not obtained; however, some agreement was found regarding the development of a logical diagnosis and treatment approach. High-quality studies are required to produce national protocols or UK guidelines.
Mathematical model to study the keyhole formation in pulsed Nd:YAG laser welding of SS 316L material and its experimental verification
Authors: Bhardwaj Vijay , Upadhyaya B. N. , Bindra K. S.
Published: July 2022

A mathematical model to study keyhole formation and its propagation in the material is developed for laser welding performed in an open atmosphere. The present model overcomes the limitations of existing models in assuming sonic vapor jet velocity to calculate vaporization-induced recoil pressure responsible for keyhole formation. In the present model, the exact value of vapor jet velocity is calculated using gas dynamics equations. The minimum threshold value of absorbed laser beam intensity required to perform keyhole welding irrespective of laser pulse duration for laser beam radius of 0.6 mm has been found to be 0.8 × 105 W/cm2 and is in good agreement with the experimental value. In between conduction mode welding and keyhole mode welding, a transition mode exists where a keyhole mechanism develops itself and melt displacement is not considerable in this zone. Weld penetration occurs mainly through heat diffusion in this transition mode. The predicted values for keyhole penetration velocity are also in good agreement with the experimental values. At a longer pulse duration, the model over-predicts the keyhole penetration velocity as compared to the experimental value due to nonconsideration of vapor plasma absorption of the laser beam.