bluuebunny/crossref_metadata_2025 huggingface dataset:
Plan de negocios para la implementación de licorería "D"Boleto" en la ciudad de Lima, 2022
Authors:   , Alagon Quispe Juan Diego Guillermo , Coloma Canela Maria del Rosario , La Rosa Huapaya Ronald Lino
Published: November 2022

El concepto surgió de la necesidad creada y desarrollada por los consumidores durante la pandemia del Covid19, donde las personas durante el transcurso de la pandemia crearon nuevos hábitos de compra, que muchas empresas notaron y se acoplaron para continuar con sus ventas en el mercado, ya que Alvarado (2020) indicó que las personas sufrieron un desenfoque en sus valores de compra y tomaron un punto que antes no eran tan significativos, como el servicio de entrega, para evitar la propagación del virus.En consecuencia, en mayo de 2022 se descubrió una nueva enfermedad que podría llevar a la vuelta a la cuarentena; hablamos del virus del Mono, que ya ha causado epidemias en países occidentales, provocando el enclaustramiento de los ciudadanos. A raíz de esta idea se plantea el presente plan de negocio, que es una licorería denominada “D¨BOLETO” que tiene el fin el expendo de bebida alcohólicas con entregas a domicilio, será implementada para la venta y distribución de una variedad de licores. El objetivo del proyecto es comercializar bebidas alcohólicas en el distrito de Santiago de Surco, Lima, teniendo en cuenta un estudio realizado por Global Research Marketing (2020), que muestra que el consumo de alcohol se incrementó en un 57% durante la pandemia en comparación con el año anterior y que, si bien la cerveza es la bebida preferida en el Perú, no fue la más vendida; ésta fue superada por el vino en primer lugar, seguido de la cerveza, el pisco, el champán, el whisky y el ron.
Implementación de un sistema de costos en una empresa de Serigrafía en el Distrito de Chosica - Lima
Authors:   , Zeballos Zavala Araceli Yezmin
Published: November 2022

En el capítulo uno se definió todos los datos fundamentales del proyecto realizado datos como información esencial con respecto al rubro averiguado, incluyendo el organigrama de funciones, foda con todas sus estrategias bien planteadas, los objetivos que tiene la empresa para lograr cumplir sus metas en un tiempo esperado. En el capítulo dos se detecta el problema esencial que tiene la empresa para lo cual se ve necesario implementar un sistema de costos y se definen los objetivos claros de la empresa y se da a conocer información sobre lo que se averiguara según autores. En el capítulo tres es donde se pondrá en marcha la implementación del sistema de sistema de costos, Esperamos que mejoren todos los flujos de información con la creación de un plan de costos y ayude a evaluar si los gastos realizados en la empresa de serigrafía sean de mucho beneficio para la empresa. En el capítulo cuatro básicamente se hace el estudio del mercado con los competidores y se evalúa porque es necesario la implementación del sistema de costos para ellos se desarrolla la técnica de la entrevista a la gerencia, esto brindara un diagnóstico ya que permite saber la situación real que está pasando la empresa sin llevar un sistema de costos. Por último, en el capítulo cinco se implementa el sistema de costos evaluando todos los puntos a analizar y se compara los resultados considerando si fue lo esperado para que el negocio siga en marcha sin problemas con los registros pertinentes para poder tener una información clara.
Abundancia y distribución espacial de ballenas barbadas y cachalotes en el mar de Perú: una revisión histórica
Authors:   , Cortez Casamayor Sarai Valeria
Published: November 2022

Existen relatos históricos de cetáceos mayores en aguas peruanas antes del inicio de la caza comercial de ballenas. La investigación sobre ballenas barbadas (suborden: Mysticeti) y cachalotes (Physeter macrocephalus) (suborden: Odontoceti) fue intensa durante la caza de ballenas, produciendo así un conocimiento esencial sobre estas especies. Las poblaciones de cetáceos mayores disminuyeron considerablemente con la presión ballenera desde 1925. Tras la moratoria de la caza de ballenas en 1985, la investigación sobre estas especies disminuyó considerablemente, produciendo un considerable vacío de conocimiento hasta la actualidad. El objetivo de esta revisión es realizar un análisis histórico de la abundancia y distribución espacial de ballenas barbadas y cachalotes en las aguas de Perú. Los resultados mostraron que, durante la época de caza comercial de ballenas, la abundancia y distribución de los cachalotes recibió la mayor parte del esfuerzo de investigación, ya que esta especie era el objetivo más importante de la flota ballenera. Después del cese de las actividades balleneras, todavía hay una considerable falta de información sobre la ballena azul (Balaenoptera musculus), la ballena de aleta (Balaenoptera physalus) y la ballena de Bryde (Balaenoptera edeni), mientras que la ballena jorobada (Megaptera novaeangliae) es la especie más estudiada debido a la actividad de observación de ballenas que se produce en la costa norte de Perú. Es necesario el desarrollo continuo de investigaciones para actualizar y complementar la información histórica.
Turismo y cambios en las expresiones culturales de la comunidad nativa Pampa Michi
Authors:   , Santos Shingari Omar Daniel
Published: November 2022

El turismo es una actividad social y como tal genera impactos. En algunos casos puede ser un aliado para la preservación de la cultura, pero en otros casos puede ocasionar cambios importantes en la cultura de los pueblos, sobre todo cuando es realizado de manera no planificada. Este artículo tiene como objetivo describir los cambios en las expresiones culturales de la Comunidad Nativa Pampa Michi que estuvieron expuestas al turismo entre los años 1998 y 2019. El estudio se realizó con un enfoque cualitativo y diseño narrativo, y se utilizaron entrevistas semiestructuradas e historias de vida como instrumentos para la recolección de datos. De acuerdo con los resultados obtenidos, las expresiones culturales de la comunidad han cambiado y ahora se muestran nuevas danzas como la pandilla o anaconda, nuevos diseños y colores en su vestimenta típica y nuevos productos y materiales en su artesanía. Se concluye que las expresiones culturales de la comunidad que estuvieron expuestas a la actividad turística han cambiado desde los inicios de esta actividad en 1998 hasta el comienzo de la pandemia.
Biosorción de plomo (II) utilizando un biosorbente obtenido a partir de la cascarilla de café (Coffea arabica L.)
Authors:   , Pariona Palomino Jordy Pier
Published: November 2022

La biosorción de metales pesados utilizando residuos agrícolas resulta ser una técnica eficiente para la descontaminación de los ríos. Por ello, se evaluó la biosorción de Pb (II) utilizando cascarilla de café como biosorbente. Para la biosorción, se utilizó un sistema batch, a temperatura ambiente 22,5 °C, agitación 300 rpm, así como, el biosorbente, la cascarilla de café la cual fue lavada, secada, triturada y tamizada a 212 μm. La densidad aparente (DA) se halló empleando una probeta; humedad por diferencia de pesos; Punto de carga cero (PZC) por diferencia de pH y grupos funcionales por espectrofotometría infrarroja (FTIR). El Pb (II) se determinó por espectrofotometría de absorción atómica. Los resultados mostraron que se obtuvo un valor de DA de 0,50 ± 0,004 g/mL; humedad 7,18 ± 0,152 %; PZC 2,20. Los grupos funcionales fueron (C=O) aldehídos y cetonas; (O-H) hidroxilo o moléculas de agua; (C-H) alcanos; (C-O) carboxilo; (C-N) grupo amino y (C-O-C) éteres. El pH favorable fue 2,0 y la dosis de biosorbente 0,5 g. Se logró el equilibrio en 10 min con eficiencia de remoción de Pb (II) de 96,45 ± 0,023 %. Predominó el modelo de pseudo-segundo orden (R2 = 0,9999). En la muestra de agua del río Rímac se removió Pb (II) en un 66,18 ± 0,95 %. En síntesis, el pH favorable está relacionado con el diagrama de Pourbaix y se observa un mecanismo de quelación, mientras que la baja concentración inicial de Pb (II) permite acelerar el tiempo de remoción y lograr el equilibrio. La muestra real mostró alta remoción a pesar de factores fisico-químicos presentes en el agua. El uso de la cascarilla de café como biosorbente representa una alternativa ecoamigable y sostenible en el tiempo.
Determinación de parámetros hematológicos de Oncorhynchus mykiss procedentes de un centro de producción acuícola del centro poblado Vilcacoto, Junín
Authors:   , Contreras Luya Claudia Fernanda
Published: November 2022

El presente trabajo tuvo como objetivo determinar los parámetros hematológicos de Oncorhynchus mykiss en un centro de cultivo ubicado en el distrito de Huancayo, según su estadio de desarrollo, con la finalidad de contribuir en el manejo sanitario de esta especie. Se colectaron muestras de sangre de 30 individuos por grupo etario (alevines, juveniles y adultos). La extracción de sangre se realizó mediante punción de la vena caudal. Los valores obtenidos de la serie eritrocítica para los estadios de alevines, juveniles y adultos, fueron respectivamente: hematocrito 6.49 ± 3.26%, 42.77 ± 4.24%, 35.47 ± 4.76%; hemoglobina 16.16 ± 1.07g/dL, 10.40 ± 0.97g/dL, 10.20 ± 1.45g/dL; eritrocitos totales 1.55 ± 0.03cel x 106/µL, 1.64 ± 0.03cel x 106/µL, 1.48 ± 0.05cel x 106/µL; VCM 415 ± 20.97µm3, 260.22 ± 23.79µm3, 239 ± 35.68µm3; HCM 104.16 ± 6.67pg, 63.33 ± 5.72pg, 68.84 ± 10.66pg y CHCM 25.07 ± 1.20%, 24.41 ± 1.78%, 28.81 ± 2.28%. En la serie leucocítica se identificaron: leucocitos totales 2.81 ± 0.09 cel x 104/ µL, 2.67 ± 0.04 cel x 104/ µL, 2.22 ± 0.05 cel x 104/ µL; linfocitos 69.49 ± 8.13%, 63.47 ± 7.68%, 71.32 ± 8.79%; neutrófilos segmentados 6.35 ± 3.33%, 7.87 ± 4.42%, 3.17 ± 1.63%; neutrófilos no segmentados 15.44 ± 9.04%, 24.68 ± 6.02%, 23.35 ± 8.44%; basófilos 0.65 ± 1.07%, 0.15 ± 0.39%, 0.14 ± 0.44% y monocitos 8.08 ± 4.23%, 3.82 ± 1.65%, 2.01 ± 1.25%. Los valores hematológicos hallados presentan características similares a las encontradas en otros estudios.
Diferencias en la percepción de la discapacidad vocal asociado al uso de micrófonos en docentes de educación secundaria de centros educativos privados mixtos de Trujillo, Perú - 2017
Authors:   , Galvez Andabak Ybka Anitza
Published: November 2022

La presente tesis es un análisis de diseño no experimental, de corte transversal, de tipo analítico correlacional, con enfoque cuantitativo, que tiene como objetivo determinar la diferencia en la percepción de la discapacidad vocal asociado al uso de micrófonos en docentes de centros educativos privados mixtos de Trujillo, Perú – 2017. Se determinó un muestreo aleatorio simple que consideró 97 docentes que cumplieron los métodos de selección. Se aplicó el instrumento de recolección de datos que fue el “Índice de Discapacidad Vocal”, se obtuvo el consentimiento informado de cada docente participante. Para validar la hipótesis se usó la prueba de U de Mann Whitney. En los resultados se halló que el 79.4% de docentes refirió que nunca hizo uso del micrófono durante sus clases. Mientras que veinte 20.6% de docentes señaló que siempre hacen uso del micrófono. Se concluye que hay desigualdades en la idea de la discapacidad vocal asociado al uso de micrófonos en docentes de centros educativos privados mixtos de Trujillo, Perú – 2017.
Inference of an Epidemic Driven by Random Transmission Rate: Explaining the Dynamics of COVID-19 in Bogotá
Authors: Ríos-Gutiérrez Andrés , Mubayi Anuj , ARUNACHALAM VISWANATHAN
Published: November 2022

The epidemic disease model is often used to predict an epidemic's characteristics and help plan an effective control strategy. Motivated by recent COVID-19 outbreaks, we develop and mathematically analyze a simple stochastic model that considers random perturbations in transmission rates and shows its validity using data from the Colombian city of Bogota. The stochastic epidemic model is stratified in the Susceptible-Exposed-Infectious-Recovered, \textit{SEIR}, type compartmental model with the randomness depicting the impact of stochastic variations due to external factors such as changes in environmental conditions and human behaviors that may impact the dynamics of an infectious disease. The analysis resulted in derivation of approximate distribution of \textit{eventual extinction of infection state}, \textit{persistence of infection in the mean}, and \textit{the quasi-stationary infectious state}). Finally, we illustrate inferences and model parameters using reported COVID-19 epidemic data from the Colombian city of Bogotá. The outbreak in Bogota is divided into six distinct periods, with transmission rates high during the initiation of the epidemic and even much higher during the last period, potentially due to the rapid spread of the Omicron variant in Colombia still has a low vaccination rate.
Mathematics Subject Classification: 92D30
Bioinformatics analysis of gene expression network regulation in osteogenic differentiation of human bone marrow mesenchymal stem cells RunningTitle: Bioinformatics analysis of osteogenic differentiation
Authors: zhang shuhong , Yao Jingke , Bai Xiaoyuan , Li Lihua , Li Shuang , Xu Xinhui , Sun Yongkun , Xu Chunyang , Zhang Hu , Wang Xianwei
Published: November 2022

Background:Among mesenchymal stem cells (MSCs), bone marrow mesenchymal stem cells (BMSCs) are considered the gold standard treatment for bone tissue regeneration. BMSCs have become an important cell source in bone and cartilage tissue engineering and regenerative medicine. However, the mechanism of osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) remains incompletely understood. In this study, we aimed to analyze the function of key gene in osteogenic differentiation of hBMSCs.Methods:From the Gene Expression Omnibus (GEO) database, we downloaded three microarray data sets: GSE12266, GSE18043 and GSE80614. Differentially expressed genes (DEGs) were screened using the ‘limma’ package, and enrichment analysis was performed. Protein–protein interaction network analysis and visualization analysis were performed in the String website and in Cytoscape software. We construct core gene regulatory network, and a reactome-based Gene Set Enrichment Analysis (GSEA) was performed on the differential genes. Experimental verification of target gene expression, osteogenic differentiation and the related markers was assessed by alkaline phosphatase (ALP) activity detection, calcium content detection, alizarin red (ARS) staining and RT-qPCR, respectively.Results:A total of 11,077 DEGs were identified, including 5296 upregulated genes and 5781 downregulated genes. Functional enrichment pathways of the identified DEGs are related to cell cycle, nuclear division, apoptosis, organelle fission, chromosomal region, centromeric region, ATPase activity, tubulin binding, microtubule blinding, shear stress, TNF signaling, etc. Further functional and correlation analyses of four core genesBRCA1,BIRC5,GMNNandTSC22D3, as well as the followed verification experiments including qPCR, ARS and ALP staining all showed thatTSC22D3andBIRC5were significantly related to the osteogenic differentiation of hBMSCs.Conclusions：This study provides a novel insight into the biological process of osteogenic differentiation of hBMSCs, and identifies novel genes for osteogenic differentiation of MSCs. Meanwhile, the findings in this study also provide potential therapeutic targets for bone tissue engineering.
SMPD1 Expression Profile and Mutation Landscape Help Decipher Genotype–Phenotype Association and Precision Diagnosis for Acid Sphingomyelinase Deficiency
Authors: Wang Ruisong , Qin Ziyi , Huang Long , Luo Huiling , Peng Han , Zhou Xinyu , Zhao Zhixiang , Liu Mingyao , Yang Pinhong , Shi Tieliu
Published: November 2022

Background
Acid sphingomyelinase deficiency (ASMD) disorder, also known as Niemann–Pick disease (NPD) is a rare genetic disease caused by mutations in SMPD1 gene, which encodes sphingomyelin phosphodiesterase (ASM). Except for liver and spleen enlargement and lung disease, two subtypes (Type A and B) of NDP have different onset times, survival times, ASM activities, and neurological abnormalities. To comprehensively explore the genotype-phenotype association and pathophysiological characteristics of NPD, we collected 144 NPD cases with strict quality control through literature mining.
Results
The difference in ASM activity can differentiate NPD type A from other subtypes, with the ratio of ASM activity to the reference values being lower in type A (threshold 0.045 (4.45%)). Severe variations, such as deletion and insertion, can cause complete loss of ASM function, leading to type A, whereas relatively mild missense mutations generally result in type B. Among reported mutations, p.Arg3AlafsX76 mutation is highly prevalent in the Chinese population, and p.R608del mutation is common in Mediterranean countries. The expression profiles of SMPD1 from GTEx and single-cell RNA sequencing data of multiple fetal tissues showed that high expressions of SMPD1 can be observed in the liver, spleen, and brain tissues of adults and in hepatoblasts, hematopoietic stem cells, STC2_TLX1-positive cells, mesothelial cells of the spleen, vascular endothelial cells of the cerebellum and the cerebrum of fetuses, indicating that SMPD1 dysfunction is highly likely to have a significant effect on the function of those cell types during development and the clinicians need pay attention to these organs or tissues as well during diagnosis. In addition, we also predicted 21 new pathogenic mutations in the SMPD1 gene that potentially cause the NPD, signifying that more rare cases will be detected with those mutations in SMPD1.
Conclusions
Our study is the first one to elucidate the effects of SMPD1 mutation on cell types and at the tissue level, which provides new insights into the genotype-phenotype association and can help in the precise diagnosis of NPD.
Codes based on basic algebras
Authors: Yılmaz Damla
Published: November 2022

In this article, we consider basic algebra, a common generalization of an MV-algebra (an algebraic counterpart of the Lukasiewicz many-valued propositional logic) and an orthomodular lattice (an algebraic counterpart of the logic of quantum mechanics). We get some results regarding b-functions and b-subsets by giving the concept of basic-function on a nonempty set V . We also build a basic code W and explore a new order of it. Finally, we prove that the corresponding orders of the basic algebra B and the basic code W generated by B are the same.
Impact of the COVID-19 pandemic on a clinical trial of pneumococcal vaccine scheduling (PVS) in rural Gambia
Authors: Hossain Ilias , Osei Isaac , Lobga Galega , Wutor Baleng M. , Olatunji Yekini , Adefila Williams , Adeshola Banjo , Isa Yasir , Nguyen Cattram , Sonko Kemo , Ceesay Lamin , Baldeh Bubacarr , Barrow Omar , Young Benjamin , Ceesay Saidina , Nyassi Abdoullah , Sarwar Golam , Barjo Ousman , Drammeh Momodou M. , Salaudeen Rasheed , Mackenzie Grant
Published: November 2022

The COVID-19 pandemic represents an unprecedented challenge for clinical research. The Pneumococcal Vaccine Schedules (PVS) study is a non-inferiority, interventional trial in which infants resident in 68 geographic clusters are randomised to two different schedules for pneumococcal vaccination. From September 2019 onwards, all infants resident in the study area became eligible for trial enrolment at all Expanded Programme on Immunisation (EPI) clinics in the study area. Surveillance for clinical endpoints is conducted at all 11 health facilities in the study area. PVS is conducted as a collaboration between the Medical Research Council Unit The Gambia (MRCG) at LSHTM and the Gambian Ministry of Health (MoH). The COVID-19 pandemic caused many disruptions to PVS. MRCG instructed interventional studies that participant enrolment be suspended on 26 March 2020 and a public health emergency was declared in The Gambia on 28 March 2020. Enrolment in PVS restarted on 1 July 2020, was suspended again on 5 August 2020 after The Gambia experienced a sharp increase in COVID-19 cases in late July 2020 and restarted again on 1 September 2020.. During periods of suspended enrolment of infants at EPI clinics PVS continued safety surveillance at health facilities, albeit with disruptions. During the periods of suspended enrolment infants who had been enrolled before 26 March 2020 continued to receive the PCV schedule to which they had been randomly allocated based on their village of residence, whereas all other infants received the standard PCV schedule. Throughout 2020 and 2021 the trial faced numerous technical and operational challenges; disruption to MoH delivery of EPI services and clinical care at health facilities, episodes of staff illness and isolation, disruption of MRCG transport, procurement, communications, human resource management, and also a range of ethical, regulatory, sponsorship, trial monitoring, and financial challenges. In April 2021 a formal review concluded that the pandemic had not compromised the scientific validity of PVS and that the trial should continue as per protocol. The continuing challenges that COVID-19 poses to PVS and other clinical trials will persist for some time.
A Pleistocene origin of the coastal platform (strandflat) in southwestern Scandinavia
Authors: Fossen Haakon
Published: November 2022

An impressively extensive shore platform, the strandflat, is cut 20-50 km into hard crystalline bedrock along most of the Norwegian coastline. Its age and origin have been debated for more than a century, including a model that it represents a weathered, buried and re-exposed Triassic surface. Resolving this issue requires integrated examination of the coastal area, including the offshore Mesozoic rift margin. Here we combine new 3D broadband seismic, bathymetric and onshore elevation data along coastal West Norway and find that the near-horizontal strandflat postdates both the west-sloping onshore “paleic” surface and the offshore Jurassic denudation surface. It also postdates tilted North Sea Neogene sediments. Consistent with low-temperature thermochronologic data, this shows that the strandflat is a Pleistocene geomorphic feature formed through periods of varying climatic conditions, facilitated by mostly rift-related fault and fracture zones. It is not, in general, part of an inherited Mesozoic landscape.
Key genes associated with Alzheimer's disease and periodontitis
Authors: Zhou Kebing , Wang Lijun , Wu Lingbo , Wu Qing , Zhu Lingping , Yang Xuefeng , li duo
Published: November 2022

Background: With increasing research on Alzheimer's disease and periodontitis, many studies suggest a close correlation between Alzheimer's disease and periodontitis, but the underlying pathophysiological mechanisms remain unclear. The aim of this study was to identify potential pivotal genes and pathways associated with both diseases by using a bioinformatics approach.
Materials/Methods: The GEO dataset GSE5281 for Alzheimer's disease patients and normal controls was downloaded from the GEO database. The GSE10334 dataset for periodontitis patients and healthy controls was also obtained. Differentially expressed genes (DEGs) for the Alzheimer's disease and periodontitis datasets were obtained, as well as genes common between them. Further GO and KEGG enrichment analyses were performed on the common genes. To determine the pathogenesis associated with Alzheimer's disease and periodontitis, protein-protein interaction (PPI) networks were constructed. Finally, the diagnostic value of HUB genes in the Alzheimer's disease and periodontitis datasets was analyzed separately using SPSS software.
Results: A total of 16 common genes were obtained for Alzheimer's disease and periodontitis with a P value <0.05. 7 GO entries and 2 KEGG pathways were obtained. In addition, the first 6 central genes (CD4, KDR, CXCR4, CXCL12, JAK2 and PTPN11) were selected with a P<0.05.
Conclusion: The results of this study suggest that some novel genes play an important role in the development and progression of Alzheimer's disease and periodontitis. More experimental studies and clinical trials are needed to validate our results.
Climate Change and Food Security in Sub-Saharan Africa
Authors: Muleta Batru Wolde
Published: November 2022

Climate change affects food security directly through temperature levels and water availability in agriculture and indirectly through its impact on disease vectors and pests. This paper investigates the economic impact of climate change on food security in SSA. Panel data of all SSA countries are used in the analysis, to analyze the impact of temperature and precipitation on food security. Their coefficient of variation is used to analyze their impact on food security. The results from the analysis indicate that the coefficient of variations in both temperature and precipitation affects food security negatively. The climate variables affect food security directly through its impact on food production and indirectly through its impact on other food security indicators. The study recommends ecosystem management and production system improvement. According to the findings, the impact of climate change on food security in the SSA region is damaging. To overcome the impact, the study suggests appropriate land use policy formulation, natural resource conservation, implementing best agronomic practices and maintaining the number of population at an optimum level in the region.
Patterns and predictors of public dental service utilisation among refugees in Victoria, Australia: A latent profile and multilevel analysis
Authors: Veginadu Prabhakar , Masood Mohd , Gussy Mark , Calache Hanny
Published: November 2022

Background
The purpose of the study was to explore, analyse, and describe the patterns of public dental services utilisation among the refugee populations in Victoria, Australia, and determine their predictors at the individual and contextual levels.
Methods
Data on the refugees who attended Victorian public dental services between July 2016 to June 2020 was gathered from the Dental Health Program dataset. Latent profile analysis was used to identify discrete groups among the refugee clientele with similar mean utilisation patterns across six indicator variables describing the attributes of dental services received and the site of care provision, over the study period. Multilevel multinomial logistic regression analysis was performed to examine the individual and contextual level correlates of the identified utilisation patterns.
Results
Six distinct profiles of public dental service utilisation were identified among the study population (n = 25542). The largest group comprised refugees predominantly using restorative services under general course of care (38.10%), followed by extraction services under emergency course of care (23.50%). Only a small proportion were estimated as having a higher mean utilisation of preventive services under general course of care (9.10%). Multilevel analysis revealed that the following variables had a significant association with refugee utilisation pattern: at the individual-level – demographic and ethnic attributes including age, gender, region of birth, preferred language for communication, use of language interpreter services, and type of eligibility card; at the contextual-level – characteristics of refugees’ area of residence including urbanicity, area-based socioeconomic disadvantage, delivery of Refugee Health Program at the community health centres, and spatial accessibility to public dental services via driving and public transit modes of travel.
Conclusions
The study represents a significant step towards the development of an evidence-based knowledge around public dental service utilisation among Victorian refugees. Overall, the study findings reiterate the critical need for targeted strategies to promote the importance of routine dental visits, oral disease prevention, and timely intervention among refugee groups.
The cisplatin-induced acute kidney injury is a novel risk factor for postoperative complications in patients with esophageal cancer: a retrospective cohort study
Authors: Ueno Shuhei , Murashima Miho , Ogawa Ryo , Saito Masaki , Ito Sunao , Hayakawa Shunsuke , Okubo Tomotaka , Sagawa Hiroyuki , Tanaka Tatsuya , Takahashi Hiroki , Matsuo Yoichi , Mitsui Akira , Kimura Masahiro , Hamano Takayuki , Takiguchi Shuji
Published: November 2022

Background
Cisplatin-induced acute kidney injury (AKI) is common during preoperative chemotherapy for esophageal cancer. The purpose of this study was to investigate the association between AKI after preoperative chemotherapy and postoperative complications in patients with esophageal cancer.
Methods
In this retrospective cohort study, we included patients who had received preoperative chemotherapy with cisplatin and underwent surgical resection for esophageal cancer under general anesthesia from January 2017 to February 2022 at an education hospital. A predictor was stage 2 or higher cisplatin-induced AKI (c-AKI) defined by the KDIGO criteria within 10 days after chemotherapy. Outcomes were postoperative complications and length of hospital stays. Associations between c-AKI and outcomes including postoperative complications and length of hospital stays were examined with logistic regression models.
Results
Among 101 subjects, 22 developed c-AKI with full recovery of the estimated glomerular filtration (eGFR) before surgery. Demographics were not significantly different between patients with and without c-AKI. Patients with c-AKI had significantly longer hospital stays than those without c-AKI (mean [95% confidence interval (95%CI)]: 27.6 days [23.3–31.9] and 43.8 days [26.5–61.2], respectively, mean difference [95%CI]: 16.2 days [4.4–28.1]). Those with c-AKI had higher C-reactive protein (CRP) levels and prolonged weight gain after surgery and before the events of interest despite having comparable eGFR trajectories after surgery. c-AKI was significantly associated with anastomotic leakage and postoperative pneumonia (odds ratios [95%CI]: 4.14 [1.30-13.18] and 3.87 [1.35-11.0], respectively). Propensity score adjustment and inverse probability weighing yielded similar results. Mediation analysis showed that a higher incidence of anastomotic leakage in patients with c-AKI was primarily mediated by CRP levels (mediation percentage 45%).
Conclusion
c-AKI after preoperative chemotherapy in esophageal cancer patients was significantly associated with the development of postoperative complications and led to a resultant longer hospital stay. Increased vascular permeability and tissue edema due to prolonged inflammation might explain the mechanisms for the higher incidence of postoperative complications.
Soil physical and biological quality in a peasant agroforestry in Southern Brazil
Authors: Charnobay Aghata C. R. , Neto Pedro H. Weirich , Auler André C. , Gomes Jaime A. , de Souza Natali M. , Hyeda Daiane , Galvão Carolina W. , Gomes Aline L. , Lima Carmen L. R. F.
Published: November 2022

Agroforestry systems bring together social, economic, and environmental services and can be alternatives for promoting development and sustainability in peasant agriculture. This study aimed to evaluate the soil physical and microbiological quality in a four-years peasant agroecological agroforestry intercropped with vegetables, located in Lapa, South Brazil. Treatments included an agroforestry row (AFS-R) managed under no-tillage and cultivated with trees for fruit and wood production; an agroforestry inter-row (AFS-I) managed with conventional tillage and cultivated with vegetables; and an area managed with conventional tillage (CT) for one year and cultivated with landrace maize. Soil physical assessments comprised soil bulk density, total porosity, macroporosity, microporosity, bioporosity, mean weight diameter of aggregates, field capacity, aeration capacity, soil saturated hydraulic conductivity, and the visual evaluation of soil structure. Microbiological indicators included soil microbial biomass, basal respiration, microbial quotient, metabolic quotient, soil organic carbon, and the most probable number of nitrogen-fixing, ammonifying, and nitrite-oxidizing bacteria. The results demonstrated that AFS-R management improved several soil physical and microbiological attributes, highlighting the importance of plants diversity, organic residues input, and no-tillage for soil quality. On the other hand, the tillage practice contributed to structural and microbiological degradation in CT, and more intensively in AFS-I, indicating that more conservationist soil management, like minimum or no-tillage, might be studied as an alternative for the cultivation of vegetable crops in agroforestry systems.
Explaining the Nutritional Behavior of Iranian Pregnant Women with Diabetes: application of Health Action Process Approach model : Across sectional study
Authors: Changizi Maryam , Mohamadian Hooshang , Shojaezadeh Davoud
Published: November 2022

Background: Gestational diabetes mellitus (GDM) is currently the most common medical complication of pregnancy. Evidence suggests that by lifestyle modifications, especially nutritional behaviors, GDM may be preventable. This study aimed to investigate the Health Action Process Approach in predicting behavior and nutrition style in diabetic pregnant mothers referred to health centers under Abadan University of Medical Sciences (southern Iran).
Method: This descriptive cross-sectional study on 82 pregnant women with diabetes referred to an urban health center. The samples were selected using simple random sampling. Data were analyzed using SPSS 25 software through descriptive tests, regression, analysis of variance, and correlation.
Results: Most pregnant mothers (41.5 %) were in the 21-30 age group. 4 3.9% of the subjects were at the moderate economic level. Linear regression test showed among demographic variables, the strongest predictor of HAPA model was income (p<0.01, R=19.9, β=-0.299).The result also showed that none of the model constructs alone predicted nutritional behavior in pregnant women. The HAPA model was able to predict 21% of the variance of the nutritional behavior (p<0.001, r=0.210, β=0.458).
Conclusion: Positive or negative outcomes, pregnant women's behavioral intent, and planning for healthy eating behaviors are effective in educating pregnant women about the prevention and control of diabetes.
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor cell invasion
Authors: Li Lifang , Wang Xuefei , Hu Kai , Liu Xinhua , Qiu Li , Bai Changsen , Cui Yanfen , Wang Biyun , Wang Zhaosong , Wang Hailong , Cheng Runfen , Hua Jialei , Hai Linyue , Wang Mengdie , Liu Miao , Song Zian , Xiao Chunhua , Li Binghui
Published: November 2022

Background
Because of the complexity and heterogeneity, therapeutic effect of breast cancer varies in each subtype, which is classified based on the molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2. Thus, novel comprehensive and precise molecular indicators in breast carcinogenesis are urgently in need.
Methods
The expression of ZNF133 in breast cancer tissues was detected by immunohistochemical staining. The interaction between KAP1 complex and ZNF133 was identified by affinity purification-coupled mass spectrometry. The regulatory mechanisms were validated by luciferase reporter assay and co-immunoprepitation. The target genes of ZNF133 was determinged by chromatin immunoprecipitation-based deep sequencing. Gain-or-loss-of-function assays were used to identify the function and underlying mechanisms of ZNF133 in breast cancer. Cancer cell proliferation, invasion, and tumorigenesis of breast cancer cells were analyzed using cell counting assays, colony formation, transwell, and xenograft tumor models.
Results
Here we report that ZNF133, a zinc-finger protein, is negatively associated with advanced pathological staging and poor survival of breast carcinomas. Moreover, ZNF133 is a transcription repressor, physically associated with the KAP1 complex and transcriptionally represses a cohort of genes including L1CAM that are critically involved in cell proliferation and motility. We demonstrate that the ZNF133/KAP1 complex inhibits the proliferation and invasion of breast cancer cells in vitro and suppresses breast cancer growth and metastasis in vivo through dampening the transcription of L1CAM.
Conclusion
Our study ascertains the value of ZNF133 and L1CAM level in the diagnosis and prognosis of breast cancer, contributes to the deeper understanding of the regulation mechanism of ZNF133 for the first time, and provides a new therapeutic strategy and precise intervention target for breast cancer.
Coronavirus spike protein-specific antibodies indicate frequent infections and reinfections in infancy and among BNT162b2-vaccinated healthcare workers
Authors: Kolehmainen Pekka , Huttunen Moona , Iakubovskaia Alina , Maljanen Sari , Tauriainen Sisko , Yatkin Emrah , Pasternack Arja , Naves Rauno , Toivonen Laura , Tähtinen Paula , Ivaska Lauri , Lempainen Johanna , Peltola Ville , Waris Matti , Kakkola Laura , Ritvos Olli , Julkunen Ilkka
Published: November 2022

The burden of seasonal human coronavirus (HCoV) infections in early childhood and adults has not been well analyzed in longitudinal serological studies. Here we analyzed the changes in HCoV (229E, HKU1, NL63, OC43, MERS, and SARS-CoV-2) spike-specific antibody levels in follow-up serum specimens of 140 children at the age of 1, 2, and 3 years, and of 113 healthcare workers vaccinated for Covid-19 with BNT162b2-vaccine. IgG antibody levels against six recombinant HCoV spike subunit 1 (S1) proteins were measured by enzyme immunoassay. We show that by the age of three years the cumulative seropositivity for seasonal HCoVs increased to 38-81% depending on virus type. BNT162b2 vaccinations increased anti-SARS-CoV-2 S1 antibodies, but no increase in seasonal coronavirus antibodies associated with vaccinations. In healthcare workers, during a one year follow-up, diagnostic antibody rises were seen in 5, 4 and 14% of the cases against 229E, NL63 and OC43 viruses, respectively, correlating well with the circulating HCoVs. In 6% of the HCWs, a diagnostic antibody rise was seen against S1 of HKU1, however, these rises coincided with anti-OC43 S1 antibody rises. Rabbit and guinea pig immune sera against HCoV S1 proteins indicated immunological cross-reactivity within alpha-CoV (229E and NL63) and beta-CoV (HKU1 and OC43) genera.
Microwave-assisted High-Throughput Synthesis of Crystalline Porphyrin-based Two-dimensional Polymers for Neuromorphic Vision Sensor
Authors: Yang Haoyong , Sun Qihao , Liao Zhongquan , Hambsch Mike , Guo Zhecheng , Wu Daheng , Jost Birgit , Zhang Yuejun , Mannsfeld Stefan C. B. , Feng Xinliang , Zhu Xiaojian , Zhang Tao
Published: November 2022

Emulating the biological visual adaptation in machine vision systems typically requires a neuromorphic vision sensor system that exhibits biomimetic light intensity-dependent photoadaptation. Inspired by the biological counterpart, porphyrin-based two-dimensional polymers (p2DPs) are of high interest for adaptative sensor due to their atomic thinness and adjustable charge transfer and trapping under light irradiations. However, the high-throughput synthesis of highly crystalline p2DPs thin films for the device application remains a great challenge because of the slow nucleation and crystallization process in classical interfacial synthesis. Here, we report a microwave-assisted interfacial methodology for the rapid synthesis (~3 mins) of p2DP thin films. The resultant film displays a long-range ordered molecular structure with a lateral size of ~23 cm2 and large crystal domains of ~4 µm as well as controllable thickness (2-40 nm). The p2DP film was then used to fabricate a vision sensor which exhibits a biomimetic light intensity-dependent photoadaptation and habituation behavior. Furthermore, a machine visual system consisting of a 4×8 p2DP-sensor array is developed to implement adaptive image recognition under bright and dim light stimuli, showing an accuracy of over 90%.
Dynamics of multipartite quantum steering for different types of decoherence channels
Authors: Li Wei-Chen , Xiao Ya , Han Xin-Hong , Fan Xuan , Hei Xiao-Bing , Gu Yong-Jian
Published: November 2022

Multipartite quantum steering, a unique resource for asymmetric quantum network information tasks, is very fragile to the
inevitable decoherence, which makes it useless for practical purposes. It is thus of importance to understand how it decays in
the presence of noise channels. We study the dynamic behaviors of genuine tripartite steering, reduced bipartite steering,
and collective steering of a generalized three-qubit W state when only one qubit interacts independently with the amplitude
damping channel (ADC), phase damping channel (PDC) or depolarizing channel (DC). Our results provide the region of
decoherence strength and state parameters that each type of steering can survive. The results show that these steering
correlations decay the slowest in PDC and some non-maximally entangled states more robust than the maximally entangled
ones. Unlike entanglement and Bell nonlocality, the sudden death of reduced bipartite steering and collective steering are
directional. In addition, we fifind that not only one party can be steered by a group system, but also two parties can be steered
by a single system. There is a trade-off between the monogamy relation involving one steered party and two steered parties.
Our work provides comprehensive information about the effect of decoherence on multipartite quantum steering, which will
help to realize quantum information processing tasks in the presence of noise environments.
Moderation of mindfulness on the relationship between anxiety and somatization symptoms in middle-aged and elderly female patients with hypertension：A cross-sectional analysis
Authors: Shen Haifei , Zhang Ri , Zhang XiuJie , Zhang Ying , Liu Yan , Song Wei , Cheng Yunpeng , Yang Minghui , Jiang Yinong , Lu Yan
Published: November 2022

Purpose: To explore the moderation of mindfulness on the relationship between anxiety and somatization symptoms in middle-aged and elderly female patients with hypertension, and provide foundation for the development of more effective mindfulness intervention strategies.
Methods: A total of 109 middle-aged and elderly female patients with hypertension were participated in this cross-sectional study from April to July 2022, who were valid responses to the Five Facet Mindfulness Questionnaire (FFMQ), the General Hospital Anxiety and Depression Scale (GHAD), and the Somatization symptom self-rating scale (SSS). The moderating effect of mindfulness was determined using multi-distance linear regression.
Results: The average quantification of all participants: mindfulness was 123.86 ± 10.49, anxiety was 7.41 ± 3.62, and somatization symptoms was 41.2 ± 9.44. In contrast to the improved level of mindfulness, anxiety (P=0.000) and somatization symptoms (P=0.001) were significantly reduced. Anxiety was positively correlated with somatization symptoms (r=-0.606, P=0.000), while mindfulness level was negatively correlated with both anxiety (r=-0.468, P=0.000) and somatization symptoms (r=-0.439, P=0.000). Moreover, mindfulness had a significant moderating effect on the relationship between anxiety and somatization symptoms (N=109) (B=-0.166, t=2.125, P=0.036). The regulation of mindfulness on anxiety and somatic symptoms was more significant in participants with low mindfulness levels (N=56) (B=0.144, t=2.805, P=0.008), but not in participants with high mindfulness levels (N=53) (B=0.037, t=-0.864, P=0.393).
Conclusion: The moderating effect analysis based on regression analysis showed that mindfulness level had a significant moderating effect on anxiety and somatization symptoms, especially in low mindfulness level.
Intrinsic room-temperature ferromagnetism in a two-dimensional semiconducting metal-organic framework
Authors: Feng Sihua , Duan Hengli , Tan Hao , Hu Fengchun , Liu Chaocheng , Wang Yao , Li Zhi , Cai Liang , Yuyang Cao , Wang Chao , Qi Zeming , Song Li , Liu X. G. , Sun Zhihu , Yan Wensheng
Published: November 2022

The development of two-dimensional (2D) magnetic semiconductors remains a challenging issue in materials science, and plays an important role in the next-generation spintronics devices. Herein, we demonstrate that a 2D semiconducting antiferromagnetic Cu-MOF can be endowed with intrinsic room-temperature ferromagnetic coupling using a ligand cleavage strategy to regulate the inner magnetic interaction within the Cu dimers. Notably, employing the element-selective X-ray magnetic circular dichroism (XMCD) technique, we provide an unambiguous evidence for intrinsic ferromagnetism. Exhaustive structural characterizations confirm that the change of magnetic coupling is caused by the increased distance between Cu atoms within a Cu dimer. Theoretical calculations reveal that the ferromagnetic coupling is enhanced with the increased Cu-Cu distance, which depresses the hybridization between 3d orbitals of nearest Cu atoms. Our work provides an effective avenue to design and fabricate MOF-based semiconducting room-temperature ferromagnetic materials, and promotes their practical applications in next-generation spintronics devices.
Effect of drilling parameters on the hole surface integrity of low alloy steel for nuclear power during BTA deep hole drilling
Authors: Li Binghao , Huang Chuanzhen , Tang Zhengyi , Chen Zhen , Liu Hanlian , Chen Zengtao , Niu Jiahui , Wang Zhen
Published: November 2022

Boring Trepanning Association (BTA) deep hole drilling is widely used in machining tube sheet of steam generator. In order to get a better service integrity, the surface quality after machining is required to be higher. In this paper, the effect mechanism of BTA deep hole drilling on the integrity and quality of the machined surface layer of low alloy steel SA508Gr.3Cl.2 for nuclear power are investigated. The results show that the gradient microstructure can be obtained by BTA drilling on the surface of inner hole, including the recrystallized layer with grain refinement and the plastic deformation layer with high density sub-crystal structure and grain distortion. With the increase of drilling speed and feed rate, the deformation layer thickness will increase. The proportion of low angle grain boundaries (LAGBs) increases with the increase of the depth from the machined surface under each drilling parameter. The increase of drilling speed leads to the increase of recrystallization degree and the proportion of LAGBs in the machined surface. The effect of feed rate on the proportion of LAGBs is opposite. The machined surface is characterized by regular peak and valley, and there are typical surface defects mainly involving feed marks, surface tearing, and ploughing grooves. With the increase of drilling speed, the surface roughness will decrease. The effect of feed rate on surface roughness is obviously lower than that of drilling speed. With the increase of drilling speed and feed rate, the depth of hardened layer increases gradually, which is caused by dislocation strengthening and fine grain strengthening effect during BTA drilling process. Higher drilling speed is recommended in forming a good machined surface with a strengthening layer of a certain thickness.