bluuebunny/crossref_metadata_2025 huggingface dataset:
Prospects and problems in implementing 4AR innovations in relation to 4IR perspectives
Authors: Saha Bornali , Islam Md Matiul , Ahmed Mohammad Bashir
Published: July 2024

The Fourth Industrial Revolution (4IR) and the concept of the Fourth Agricultural Revolution (4AR) are interconnected, as they both refer to the application of advanced technologies. The Fourth Industrial Revolution has the power to revolutionize agriculture, enabling farmers to embrace innovation, increase productivity, and foster sustainable practices. The purpose of this study was to determine the extent of knowledge and attitude of respondents; to determine the familiarity of the respondents with 4AR technologies, to measure the severity of problems perceived by the respondents concerning 4AR, to find out the suitability of solutions for adopting 4AR innovations and to explore the relationship between each of the selected characteristics of the respondents with the focused issues. Primary data were collected from purposively selected 70 respondents during the period of 1 May, 2023 to 9 May, 2023 at Khulna district through face-to-face discussions and online interviews by using a pre-tested interview schedule. Descriptive statistics such as mean, standard deviation, percentage and Spearman Coefficient of Correlation  were measured for data interpretation by using SPSS. Almost 72.9% of the respondents had low knowledge of 4AR technologies and a proportion of 95.7% of the respondents had a favorable attitude toward 4AR. Maximum respondents are highly familiar with the technology of “Using an automated machine for seedling transplantation” and “Using agricultural drones in applying fertilizers and pesticides in crop fields”. The main problem based on the problem severity index was “High initial investment to purchase 4AR technologies”. The best possible solutions according to the solution index were making the 4AR technologies available at low prices in the local market” followed by financial support from the Government and other agencies. Knowledge and attitude towards 4AR technologies had a significant positive relationship with the familiarity of 4AR technologies. Training experience had a highly significant relationship with the determination of associated problems in 4AR implementation. Knowledge of 4AR and training experience had a highly significant positive relationship with the measurement of the suitability of probable solutions.
Int. J. Agril. Res. Innov. Tech. 14(1): 77-86, June 2024
Farmers’ attitude towards modern maize production in Dinajpur Sadar upazila
Authors: Hossain Md Belal , Mondol Md Abu Sayed , Goswami Pallab , Huda Saiful
Published: July 2024

The vital determination of the study was to determine the farmers’ attitudes towards modern maize production. The study was carried out in the Chehelgazi unions of Sadar upazila under Dinajpur District. Ninety-two farmers were selected as sample from an updated list of 920 farmers involved in maize production. Data were collected by a pre-tested interview schedule during September to October 2017. Simple and direct questions with different scales were used to obtain information. The co-efficient of correlation (r) was computed to explore the relationships between the nine selected characteristics of the farmers and their attitude towards modern maize production. About three-fourths (73.9%) of the farmers had highly favorable attitude towards modern maize production, while 26.1%  moderately favorable attitude and none of them had slightly favorable attitude towards modern maize production. Correlation analyses indicated that among nine selected characteristics, education, farm size, cosmopoliteness, and extension media contact of the farmers had significant positive relationships with their attitude towards modern maize production. However, age, family size, area under maize production, annual income and training received had no significant relationships with their attitude towards modern maize production. ‘Cost of modern maize production is high than other crops’ (78.3%) emerged as the 1st ranked problem and last ranked (25.0%) perceived problem mentioned by the farmer was ‘Lack of knowledge on hybrid maize variety’ expressed by the farmers. The vital (56.5%) suggestion cited by the farmers was ‘organizing more training program for the farmers’ and ‘Application of IPM technique’ (28.3%) was last suggestion.
Int. J. Agril. Res. Innov. Tech. 14(1): 96-103, June 2024
Exploratory Descriptive on the Self-Confidence of Prospective Accountants Toward Economic Digitalization
Authors: Kusumawardani Anisa , Dhian Andanarini Minar Savitri  , Aurel Ariandrani
Published: July 2024

One of the key characteristic features of change in the modern socio-economic environment is information, which manifested in both the dynamic development of the information within the communication technology and in the transformation of the information itself into a strategic resource for the entities’ welfare, especially for an economic entity inside the turbulence of an ever-changing world. Accounting is considered one of the fragments that is significantly impacted by the speeding up of digital transformation. Academics and practitioners have noted several difficulties and issue that comes to the surface concerning the decline of accounting functionality and the reporting value of the information for stakeholders. The existence of new technological capabilities such as artificial intelligence does not eliminate the possibility of alteration on the role of an accountant, and this can create tension for students majoring in accounting. Whether it is a threat or an opportunity for accounting development for the 'generation Z’ facing the AI era. The existing volatility assessment of the future accounting profession has contributed to the decline in motivation of the current generation to see the prestige of the accounting profession, and negatively affected the demand for accounting education. This study examines how future accountants undergo formal education in the face of the digital accounting era, provide actionable recommendations for individuals and organizations to build and maintain self-confidence in the context of Industry 5.0. The analysis used in this study is qualitative methods with phenomenological approaches analyze with QSR NVivo12 which leads to the conclusion that the current vision and role of an accountant who was previously called a record holder must develop to a bigger role that possesses a certain influence within the present-day market and society. The function of an accountant cannot be fully automated, due to the wide variety of accounting functions that require professional judgment based on systems of expertise, experience, and intuition. By achieving a comprehensive vision and role, the acceleration of accounting information technology will require the role of an accountant and not vice versa.
Potensi Inokulan Trichoderma harzianum (R3) Bagi Pertumbuhan Bibit Jeruk Siam Pontianak (Citrus nobilis var. microcarpa) pada Tanah Gambut
Authors: Fadhkurrahman Muhammad Dzaki , Rahmawati Rahmawati , Gusmalawati Dwi , Mukarlina Mukarlina
Published: July 2024

Trichoderma sp. membantu menyediakan unsur hara bagi tanaman dengan mempercepat terjadinya  dekomposisi senyawa organik. Penelitian ini bertujuan untuk mengetahui pertumbuhan bibit jeruk siam pontianak pada tanah gambut dengan pemberian inokulan T. harzianum (R3). Desain penelitian menggunakan Rancangan Acak Lengkap (RAL) perlakuan sebanyak lima, masing-masing empat ulangan. Variabel pengamatan berupa tinggi tanaman, jumlah daun, berat basah dan berat kering tanaman. Berdasarkan uji analisi sidik ragam, pemberian inokulan T. harzianum (R3) tidak memiliki pengaruh nyata pada tinggi tanaman dan jumlah daun, akan tetapi memiliki pengaruh nyata pada berat basah dan berat kering tanaman. Pemberian 50 g inokulan T. harzianum (R3) merupakan dengan perlakuan terbaik untuk pertumbuhan bibit jeruk siam pontianak.
Instalasi Proteksi Kebakaran pada Gedung Laboratorium Menggunakan Detektor Panas dan Detektor Asap
Authors: Pinto Gaspar Pereira Maia , Setyanto Djoko , Soewono Arka Dwinanda
Published: July 2024

Maraknya berbagai kasus kebakaran perlu diminimalisir melalui sistem proteksi kebakaran menggunakan peralatan yang digerakkan secara manual atau otomatis untuk mendeteksi sekaligus memadamkan kebakaran sedini mungkin. Perubahan suhu dan asap yang muncul di lokasi dapat menjadi parameter deteksi dini kebakaran tersebut. Tesis ini berhasil menentukan jumlah dan titik detektor serta instalasi proteksi kebakaran gedung laboratorium sesuai dengan Standard Nasional Indonesia (SNI) dan Regulasi Indonesia, yakni perhitungan jumlah detektor yang diperoleh 44 buah, terbagi atas 22 detektor panas dan 22 detektor asap, untuk lantai 1 terinstal 16 detektor, 8 detektor asap dan 8 detektor panas, lantai 2 terinstal 16 buah terdiri dari 8 detektor panas dan 8 detektor asap sedangkan lantai 3 terinstal 12 buah dengan 6 detektor panas dan 6 detektor asap.
Desain Sistem Kontrol Container Station Menggunakan Metode Waterfall Berbasis Internet of Things (IoT)
Authors: Erdani Yuliadi , Pratama Rizqi Aji , Ahad Bahdin Ahad , Fadila Ginna Intan Fadila
Published: July 2024

Industri logistik dan manajemen container menghadapi tantangan signifikan dalam pengelolaan container station, seperti kompleksitas operasional, risiko keamanan, dan kurangnya visibilitas. Hal ini dapat menyebabkan kerugian ekonomi yang besar akibat kehilangan atau kerusakan barang, keterlambatan pengiriman, serta pelanggaran keamanan. Penelitian ini bertujuan merancang sistem kontrol container station menggunakan metode waterfall berbasis internet of things (IoT). Metode waterfall dipilih untuk pendekatan sistematis dan terstruktur, sementara IoT memungkinkan pemantauan dan pengendalian jarak jauh secara real-time. Metode waterfall digunakan untuk memastikan pengembangan sistem dilakukan secara berurutan dari analisis kebutuhan, system desain, implementasi, pengujian, hingga pemeliharaan sistem. Pengiriman data pada sistem ini dilakukan menggunakan protokol Message Queuing Telemetry Transport (MQTT). Hasil pengujian menunjukkan integrasi antara perangkat Programmable Logic Controller  dan jaringan Internet of Things sukses terwujud melalui NodeMCU sebagai penghubung. Aplikasi Blynk digunakan untuk kontrol dan pemantauan container station. Dengan aplikasi ini, pengguna dapat dengan mudah mengontrol dan memantau container station melalui push button dan Lihgt Emition Diode (LED).
Perancangan Arsitektur Enterprise Teknologi Informasi Menggunakan Metode TOGAF ADM (Studi Kasus : SMK Negeri 1 Manokwari)
Authors: Turukay Yodhy Yabes Yulezar , Kweldju Alex De , Baisa Lorna Yertas
Published: July 2024

SMK Negeri 1 Manokwari yakni  sekolah SMK Negeri di kota Manokwari, Papua Barat. Saat ini SMK Negeri 1 belum mempunyai SI/TI yang terintegrasi guna mendukung proses bisnisnya, contohnya pendaftaran siswa baru, pengelolaan data kepegawaian, dan pengaturan keuangan sekolah masih dikerjakan dengan manual.  penelitian ini bertujuan melakukan pengembangan arsitektur enterprise SI/TI yang selaras dengan kebutuhan bisnis yang terus berkembang. Dalam penelitian ini, arsitektur enterprise teknologi informasi dirancang menggunakan metodologi Open Group Architecture Framework (TOGAF), dengan 5 tahap awal TOGAF ADM: Visi Arsitektur, Pendahuluan, Arsitektur Aplikasi & Data, Arsitektur Bisnis, dan Arsitektur Teknologi. Penelitian ini menghasilkan portofolio aplikasi SIPS, SIK, dan SIKU. Rekomendasi portofolio aplikasi memungkinkan deskripsi kriteria aplikasi untuk pengambilan keputusan dan pengembangan aplikasi di masa mendatang, dengan menggunakan Matriks McFarland's untuk mengklasifikasikan aplikasi seperti SIPS, SIK, dan SIKU berdasarkan pada kuadran strategic, high potential, key operation, serta support untuk menghasilkan proses bisnis yang maksimal di sekolah SMK Negeri 1 Manokwari.
Teaching as Dwelling Between Two Worlds: Reflection of Being an Educator in the Post-Pandemic Era
Authors: Liu Baergen Patricia
Published: July 2024

This paper discusses the impact of COVID-19 on education, focusing on the rapid shift to online learning. It raises concerns about the ethical implications of AI-generated writing and critiques the dominance of technocratic rationality in education. Drawing from Ted Tetsuo Aoki and Martin Heidegger’s works, it explores the notion of technology, poetic dwelling, and the educators’ beingness in a post-pandemic era. This paper challenges instrumental views on curriculum, teaching, and technology through personal reflections and theoretical analysis, advocating for an existential and poetic understanding. This paper urges rethinking educational practices to embrace human complexity and foster genuine engagement with knowledge.
Self-Efficacy, Motivation, and Employee Performance in Hospitality Industry: A Mediation Analysis
Authors: Wardhana Daniel Yudistya , Harsono Harsono
Published: July 2024

It is hypothesized in several research that that times of crisis and turbulence can lead to considerable changes in how organizations, especially those in the inherently volatile tourism industry, manage their strategies. This research primarily aimed to investigate the relationship between self-efficacy and employee performance, with an emphasis on the intermediary role of motivation in a hospitality companies located in Yogyakarta, Indonesia. To fulfil this aim, a quantitative approach was adopted, involving a survey distributed to a group of 100 employees. The gathered data was then examined using Partial Least Square-Structural Equation Model (PLS_SEM) to determine the effect of each variable. The results of the study indicated that Self-Efficacy had significant influence on Motivation and Performance. Also, the results that the indirect path of self-efficacy, motivation and performance is significant and positive and classified as partial mediation. This research offers practical implications for the tourism industry particularly in terms of how effective the management of tourism companies, as business stakeholders maintain their employee’s performance effectively through real implementation particularly during periods of crisis.
Penanganan Pembiayaan Gadai Bermasalah pada BMT Syariah NU Ngasem Kantor Cabang Paron Kabupaten Ngawi
Authors: Sulandari Siti , Kasmiati Kasmiati
Published: July 2024

Pembiayaan adalah pendanaan yang diberikan oleh suatu pihak kepada pihak lain untuk mendukung investasi yang telah direncanakan. Dalam Lembaga keuangan perbankan Syariah pembiayan merupakan asset yang harus dihajar kualitasnya dengan mendasar pada prinsip kehati-hatian. Rahn adalah merupakan salah satu bentuk perjanjian utang piutang, yang mana mendapatkan sautu kepercayaan dari orang yang berpiutang. Pembiayaan Rahn Tasjily adalah akad yang dimana menjamin suatu barang atas utang seorang, dimana kesepakatan diantara kedua belah pihak menyatakan bahwa peminjam hanya menyerahkan bukti sah kepemilikannya kepada si penerima jaminan (murtahin), sehingga fisik dari barang jaminan tersebut tetap berada dalam penguasaan dan pemanfaatan pemberi jaminan (rahin). Realisasi pembiayaan bukan tahap terakhir dari proses pembiayaan karena mustahil dalam jangka waktu yang panjang tidak terjadi pembiayaan bermasalah. Yang menjadi pokok permasalahan dalam penelitian ini adalah bagaimana metode penanganan
yang diterapka oleh BMT dalam upaya penyekesaian pembiayaan bermasalah. Jenis penelitian yang digunakan adalah penelitian kualitatif yaitu dengan penelitian lapangan. Metode pengumpulan data melalui wawancara dan dokumentasi. Dari hasil penelitian ini dapat diketahui bahwa penyelesaian pembiayan bermasalah di BMT NU Ngasem cabang Paron mengunakan tiga metode yakni metode pendekatan, Restructuring (Penataan kembali), dan rescheduling (Penjadwalan kembali).Kata Kunci : Rahn, Pembiayaan bermasalah, Penyelesaian
Cash Waqf Linked Sukuk (CWLS) sebagai Implementasi Filantropi Islam Berkelanjutan
Authors: Alfidhatun Siti
Published: July 2024

Cash Waqf Linked Sukuk (CWLS) is an innovative instrument of state sukuk with waqf. The novelty of this innovation needs to be analyzed for the distribution of funds and their usefulness. The purpose of this research is to analyze the impact of CWLS in Islamic philanthropy. This research uses qualitative methods with library research. The data obtained comes from OJK financial reports, journals, articles, and documents related to CWLS. The results of this study show that the first series of CWLS (SW0001) was used for the development of the Retina and Glaucoma center at Achmad Wardi Eye Hospital, Serang, Banten Province. This is in accordance with Islamic philanthropy as a form of social and sustainable generosity.
Role of Coronary Physiology in the Modern Catheterisation Lab
Authors: Occhipinti Giovanni , Brugaletta Salvatore
Published: July 2024

Over the past two decades, invasive coronary physiology assessment has advanced significantly. Despite the proven prognostic significance provided by invasive physiological assessment of lesions by means of fractional flow reserve or adenosine-free non-hyperaemic pressure ratios, challenges in clinical practice hinder widespread adoption and limit additional value for optimising percutaneous coronary intervention decisions. Despite notable progress, uncertainties persist, emphasising the need for further research to establish a single numerical parameter in the diagnosis of a functionally significant disease, clarify the impact of longitudinal vessel analysis, and support the relevance of pressure indices in post-intervention optimisation.
Innovative Strategies for Chronic Total Occlusions
Authors: Thornber Katrina
Published: July 2024

CHRONIC total occlusion percutaneous coronary intervention (CTO PCI) strategies were thoroughly discussed at the EuroPCR 2024 Annual Global Course in Paris, France. Experts in the field gathered to discuss the advantages and limitations of various approaches, including the use of intravascular ultrasound (IVUS) when locating ambiguous proximal caps. Experts discussed several techniques in the context of success rate and patient safety, with a focus on what changes can be made to current guidelines to ultimately improve patient outcomes in high-risk cases.
Challenges of Using Publicly-Available Hospital Data to Quantify Health Effects from Wildfire Plumes in the East San Francisco Bay Area Communities of California, USA
Authors: Atkins Natasha , Baskett Ronald
Published: July 2024

In the summer and fall of 2018 and 2020, major wildfires in Northern California (USA) impacted the San Francisco Bay Area. The remote 2018 and 2020 wildfires produced the highest PM2.5 concentrations experienced in the Tri-Valley of the East Bay Area during those two years. The Tri-Valley is composed of the San Ramon, Amador, and Livermore Valleys, surrounded by local terrain that creates a small airshed. In 1967, the California Air Resources Board created 15 Air Basins defined by regional geography, topographic and meteorological conditions. Airshed is sometimes synonymous with an urban-scale component of an Air Basin. We use airshed as a Tri-Valley component of the Bay Area Air Basin. This airshed spans across two counties (Contra Costa and Alameda) and encompasses four cities: San Ramon, Dublin, Pleasanton, and Livermore. PurpleAir (PA) sensors provided good geographic coverage of variation in PM2.5 in the Tri-Valley airshed. Several studies have established significant health effects from wildfire plumes by associating daily hospital visits with PM2.5 air quality data at local and regional scales. We hypothesize that during the wildfire smoke periods of 2018 and 2020 in the Tri-Valley area, there was an increase in hospitalizations and ED visits for respiratory (asthma and COPD-related) health effects, as compared to the same time periods during years with less fire activity. The primary goal of this study was to confirm health effects from wildfire plumes on a community scale using 5 years of publicly-available health data. However, with only monthly hospitalization data available, directly linking respiratory hospital and emergency department (ED) visits with PM2.5 concentrations was unsuccessful. Also, because COVID-19 masked all other causes of hospital visits in 2020, that year was ultimately eliminated from this study. However, visits during November 2018 being much higher than any other November in 2016, 2017, and 2019 implied a potential cause and effect. Daily hospitalization and air quality data are required to quantify any relationship by regression analysis. These findings help inform future studies on the health effects of air quality at community scales. KEYWORDS: PM2.5 Air Quality; Air Pollutant Exposure; Air Quality Monitoring; Wildfire Smoke; Respiratory Health; PurpleAir Sensors
Undergraduate Students’ Confidence in Scientific Activity and Support Systems Based on Diversity in an Environmental Science Course
Authors: Parris Kimberly , Leggett Zakiya , Spence Porche
Published: July 2024

Undergraduate student support systems and individual confidence in science courses have been linked to better academic performance among college students. As the topics of diversity and inclusion continue to draw the attention of the collegiate, the problem of equity surrounding supportive learning environments for all races in higher education comes into focus. This paper adds to the literature by highlighting the importance of adequate support for students in collegiate settings. Disparities in student support and confidence with scientific activities among students of color (SOC) and white students in an undergraduate environmental science course had been evaluated. Students (n = 235) were asked to complete a Qualtrics survey containing questions focused on evaluating support from parents, siblings, close relatives, friends, peers, classmates, and professors and confidence regarding self-efficacy in learning and doing scientific activities. The perceived support and confidence in scientific activities in white students and SOC were measured using an independent T-test. The findings demonstrated that white students may have had access to stronger support systems and had higher perceived confidence levels in completing scientific activities based on survey responses. On average, white students had greater perceived support and more confidence. As a result, higher dropout rates, lower performance overall, and alienation of these students in higher education environments could occur. If this trend continues, racial discrepancies suggest that students of color need stronger support networks related to scientific activities in higher education settings. KEYWORDS: Student Support; Student Scientific Confidence; STEM Confidence; Students of Color; Academic Support; Undergraduate Student; Family Support; Student Peers
ANALISIS KESIAPAN PEGAWAI NEGERI SIPIL DALAM MENGHADAPI IMPLEMENTASI DELAYERING
Authors: Iswandari Virginia Dewi
Published: July 2024

Keberhasilan implementasi suatu perubahan dipengaruhi oleh tingkat kesiapan individu maupun kolektif serta bagaimana implikasi perubahan tersebut pada lingkungan kerja pegawai. Penelitian ini bertujuan untuk menganalisis kesiapan pegawai untuk berubah pada organisasi sektor publik dengan konteks perubahan delayering. Data penelitian terbagi menjadi dua, data kuantitatif dikumpulkan melalui survei terhadap 225 pegawai negeri sipil di lingkungan Badan Pendidikan dan Pelatihan Keuangan (BPPK) yang sedang dalam proses implementasi kebijakan delayering, sementara data kualitatif dikumpulkan melalui wawancara terhadap pejabat struktural di lingkungan BPPK yang nantinya akan terdampak delayering. Pengolahan data dilakukan dengan Structural Equation Method (SEM) berbasis Covariance-Based Structural Equation Modelling (CBSEM) dengan aplikasi LISREL, sementara data kualitatif diolah dengan aplikasi RQDA. Hasil penelitian menunjukkan bahwa secara umum change beliefs memiliki pengaruh positif dan signifikan terhadap kesiapan pegawai untuk berubah, namun secara rinci tidak semua dimensi dalam change beliefs menunjukkan pengaruh yang sama. Dimensi change efficacy dan principal support memiliki pengaruh positif dan signifikan terhadap kesiapan pegawai untuk berubah. Sedangkan dimensi lainnya tidak menunjukkan pengaruh yang sama. Hal ini menjadi indikasi bahwa kedua faktor tersebut memegang peranan yang paling penting pada keberhasilan implementasi inisiatif delayering pada objek penelitian. Penelitian ini dapat menjadi dasar untuk melakukan analisis kesiapan pegawai dalam menghadapi delayering pada instansi pemerintahan lainnya atau untuk jenis jabatan lainnya.
 
Kata Kunci: Kesiapan Pegawai Untuk Berubah; Change Beliefs; Delayering; Sektor Publik.
A connection between twin primes and Riemann zeta function, and a possible way to proof the twin prime conjecture
Authors: Omran Saleh
Published: July 2024

In the present work, we found out a connection between twin primes and Riemann zeta function. This connection may be a possible way to proof the twin prime conjecture. Twin prime conjecture states that there are in�nitely many primes p such that p+2 is also prime. Using the value of zeta function (1) = , we give a possible proof based on the proof by contradiction, that is the conjecture is true.
Eliminating the Term Vψ and Coefficient 1/2 From Schrodinger’s Wave Equation
Authors: Soltani Abolfazl
Published: July 2024

The validity of the de Broglie formula λ=h⁄p for matter waves has been confirmed by numerous experiments such as Davisson-Germer and G. P. Thomson experiments. But there is a major problem here. If λ=h⁄p is valid for matter waves, we must be able to obtain it for these waves using mathematical calculations. But as you will see here, according to de Broglie's hypothesis, which considers matter wave energy equal to E=hf, this work is impossible; and so, we must change the matter wave energy equation to obtain λ=h⁄p. The change in the equation of energy causes two important changes in Schrodinger’s wave equation. These two changes bring us to a new wave equation. In the fourth part of the article you will see that, for explanation of the reason for the quantization of the orbits in Bohr's atomic model, we need a new atomic model for the Hydrogen atom. The new model leads us to new results and findings. In this article, we show what the cause of the quantization of the orbits in the Bohr atomic model is.
The methodological basis of field experiments with forage crops
Authors: Shpakov Anatoly , Novoselov Yuriy , Har'kov Georgiy , Volovik Valentina , Truzina Lyudmila , Prologova Tat'yana , Ulanov Anatoliy , Laretin Nikolay , Sergeeva Svetlana , Usol'ceva Tat'yana
Published: July 2024

This paper outlines the methodological basis for conducting field experiments with forage crops. Based on modern trends in the development of livestock farming and feed production, an integrated approach and the organization of environmental, resource-saving and environmentally friendly feed production systems, classical and latest methods of conducting field experiments on technologies for cultivating basic feed crops are presented in order to increase their productivity, energy and protein nutrition of bulk and concentrated feeds, substantiation of the structure of sown areas and crop rotation systems, development of models for the organization and management of resource-saving, environmentally friendly agroecosystems. This publication is intended for researchers, graduate students and teachers of educational institutions conducting research work in the field of field forage production.
Analisis Terhadap Bidang Usaha Pertanian Pada Disperindag Kabupaten Bener Meriah Melalui Model Bisnis Kanvas
Authors: Musdhalipah  , Fauzi Achmad
Published: July 2024

Pada penelitian ini merujuk pada komoditi perdagangan daerah di kabupaten bener meriah dengan meliputi hasil pertanian kopi, tomat, dan cabai. Pembaharuan tersebut terhadap hasil produk dengan label yang lebih unggul untuk dapat dipertahankan oleh masyarakat maupun sektor pertanian yang berkelanjutan terhadap hasil produk tani ini merambah dengan skala nasional untuk memajukan pertanian daerah secara luas. Adapun indikasi hasil panen tercatat mencapai persentase 88% dengan cakupan yang signifikan pada instansi tersebut, sehingga dapat mengungguli hasil tani dengan daerah lain. Metode ini menggunakan teknik kualitatif berdasarkan konsep awal melaui model bisnis kanvas. Konsep tersebut untuk didapatkan bagaimana proses awal hingga dapat didistribusikan keberbagai daerah, serta dapat memaksimalkan pendapatan masyarakat yang menuju Indonesia Sejahtera. Dalam peningkatan pada hasil tani ini tentunya didukung oleh OPD terkait melalui peran serta dengan peningkatan model bisnis yang akan terus ditekuni dengan melihat cakupan distribusi yang merata. Adapun hasil akhir dari penelitian ini untuk memberikan literasi informasi yang dapat digunakan oleh instansi sebagai kelengkapan data pada hasil tani di kabupaten bener meriah.
The pathogenic mechanism of monosodium urate crystal-induced kidney injury in a rat model
Authors: Li Delun , Li Yimeng , Chen Xuesheng , Ouyang Jianting , Lin Danyao , Wu Qiaoru , Fu Xinwen , Quan Haohao , Wang Xiaowan , Wu Shouhai , Yuan Siyu , Liu Anqi , Zhao Jiaxiong , Liu Xiaowu , Zhu Gangxing , Li Chuang , Mao Wei
Published: July 2024

Objective

(MSU) crystals usually in the kidney tubules especially collecting ducts in the medulla. Previous animal models have not fully reproduced the impact of MSU on kidneys under non-hyperuricemic conditions.

Methods

In the group treated with MSU, the upper pole of the rat kidney was injected intrarenally with 50 mg/kg of MSU, while the lower pole was injected with an equivalent volume of PBS solution. The body weight and kidney mass of the rats were observed and counted. H&E staining was used to observe the pathological damage of the kidney and to count the number of inflammatory cells. Masoon staining was used to observe the interstitial fibrosis in the kidneys of the rat model. Flow cytometric analysis was used for counting inflammatory cells in rats. ElISA was used to measure the concentration of serum and urine uric acid, creatinine and urea nitrogen in rats.

Results

At the MSU injection site, a significantly higher infiltration of inflammatory cells and a substantial increase in the area of interstitial fibrosis compared to the control group and the site of PBS injection were observed. The serum creatinine level was significantly increased in the MSU group. However, there were no significant differences in the rats’ general conditions or blood inflammatory cell counts when compared to the control group.

Conclusion

The injection of urate crystals into the kidney compromised renal function, caused local pathological damage, and increased inflammatory cell infiltration and interstitial fibrosis. Intrarenal injection of MSU crystals may result in urate nephropathy. The method of intrarenal injection did not induce surgical infection or systemic inflammatory response.
River chief governance in China: trends and outlooks
Authors: Yang Chenxinyi , Song Tao
Published: July 2024

The issue of water resources is a perennial topic for achieving human sustainable development goals. Over the last decade, a renewed watershed governance regime, River Chief System emerged to solve the issue of river pollutions in China, and attracted attentions across the world. In this review article, we profiled River Chief System, including its origin, principle and characteristics, and found that the primary feature of River Chief System is its hierarchical structure and the implementation of responsibility. By triangulating bibliometric measurement of the Citespace tool, database of the Web of Science and the China National Knowledge Infrastructure, the development, research trends and hotspots of River Chief System research have been reviewed systematically. The number of publications of River Chief System is showing a significant growing trend, and their foci are diverse: water environmental effects, mechanisms of River Chief System, public participation and supervision and localization of River Chief System, and the implement of “One River, One Policy” plan. Finally, theoretical and practical suggestions for the future study of River Chief System are proposed. This review systematically introduces China’s experience on river management to the world, which is of great significance for the world to fully understand the River Chief System of China and further improve and promote it.
Causal association between phenylalanine and Parkinson’s disease: a two-sample bidirectional mendelian randomization study
Authors: Li Shiqing , Song Huangcheng , Yu Cong
Published: July 2024

Background

Research findings indicate a putative indirect or latent association between phenylalanine (Phe) and Parkinson’s disease (PD). In this study, we aimed to analyze the causal relationship between Phe and PD by two sample Mendelian randomization (MR) analysis.

Methods

In this study, the PD-related dataset and Phe-related dataset were downloaded from Integrative Epidemiology U1nit (IEU) Open Genome-Wide Association Study (GWAS) database. Four algorithms (MR Egger, maximum likelihood, inverse variance weighting (IVW) and unweighted regression) were used to perform MR analysis. The sensitivity analysis (heterogeneity test, horizontal pleiotropy test and Leave-One-Out (LOO) analysis) was used to assess the reliability of MR analyses.

Results

In the forward MR analysis, Phe was a safety factor for PD (p-value < 0.05 and odds ratios (OR) < 1). The results of reverse MR analysis showed that there was no causal relationship between PD and Phe (p-value > 0.05). In addition, sensitivity analysis showed that MR analysis was reliable.

Conclusion

The results of this study revealed that Phe was a safety factor for PD, meaning that Phe reduced the risk of PD.
CX3CL1 release during immunogenic apoptosis is associated with enhanced anti-tumour immunity
Authors: Naessens Faye , Demuynck Robin , Vershinina Olga , Efimova Iuliia , Saviuk Mariia , De Smet Greet , Mishchenko Tatiana A. , Vedunova Maria V. , Krysko Olga , Catanzaro Elena , Krysko Dmitri V.
Published: July 2024

Introduction

Immunogenic cell death (ICD) has emerged as a novel option for cancer immunotherapy. The key determinants of ICD encompass antigenicity (the presence of antigens) and adjuvanticity, which involves the release of damage-associated molecular patterns (DAMPs) and various cytokines and chemokines. CX3CL1, also known as neurotactin or fractalkine, is a chemokine involved in cellular signalling and immune cell interactions. CX3CL1 has been denoted as a “find me” signal that stimulates chemotaxis of immune cells towards dying cells, facilitating efferocytosis and antigen presentation. However, in the context of ICD, it is uncertain whether CX3CL1 is an important mediator of the effects of ICD.

Methods

In this study, we investigated the intricate role of CX3CL1 in immunogenic apoptosis induced by mitoxantrone (MTX) in cancer cells. The Luminex xMAP technology was used to quantify murine cytokines, chemokines and growth factors to identify pivotal regulatory cytokines released by murine fibrosarcoma MCA205 and melanoma B16-F10 cells undergoing ICD. Moreover, a murine tumour prophylactic vaccination model was employed to analyse the effect of CX3CL1 on the activation of an adaptive immune response against MCA205 cells undergoing ICD. Furthermore, thorough analysis of the TCGA-SKCM public dataset from 98 melanoma patients revealed the role of CX3CL1 and its receptor CX3CR1 in melanoma patients.

Results

Our findings demonstrate enhanced CX3CL1 release from apoptotic MCA205 and B16-F10 cells (regardless of the cell type) but not if they are undergoing ferroptosis or accidental necrosis. Moreover, the addition of recombinant CX3CL1 to non-immunogenic doses of MTX-treated, apoptotically dying cancer cells in the murine prophylactic tumour vaccination model induced a robust immunogenic response, effectively increasing the survival of the mice. Furthermore, analysis of melanoma patient data revealed enhanced survival rates in individuals exhibiting elevated levels of CD8+ T cells expressing CX3CR1.

Conclusion

These data collectively underscore the importance of the release of CX3CL1 in eliciting an immunogenic response against dying cancer cells and suggest that CX3CL1 may serve as a key switch in conferring immunogenicity to apoptosis.
Association of inflammatory score with all-cause and cardiovascular mortality in patients with metabolic syndrome: NHANES longitudinal cohort study
Authors: Chen Yan , Ju Haonan , Xie Kailing , Zhao Xin
Published: July 2024

Background

Inflammatory scores are known to reflect the systemic inflammatory burden. Despite this, the association between the inflammatory score and the risk of all-cause and cardiovascular mortality in patients with metabolic syndrome (MetS) remains poorly understood. To address this gap in the literature, this study investigated this potential association between these two factors.

Methods

A total of 3401 patients with MetS from the National Health and Nutrition Examination Survey (1999–2010) were enrolled. Survival status and cause of death were obtained by linking data from the National Death Index (NDI). The inflammatory score was calculated based on the sum of the Z-scores for white blood cell (WBC) count and C-reactive protein (CRP) at baseline. The patients were divided into inflammatory score quartiles. Cox proportional hazards regression was used to determine the association between inflammatory score and mortality. Restricted cubic splines (RCS) were used to explore the dose-response relationship between inflammatory score and mortality. Stratified analyses and interaction tests were conducted according to sex, age, body mass index (BMI), alcohol consumption, smoking status, hypertension, diabetes, and stroke status.

Results

After a mean follow-up of 145.9 months, 1039 all-cause deaths and 295 cardiovascular deaths were recorded. The results of multivariate Cox regression analysis showed that compared to the lowest quartile (Q1), patients in the highest quartile (Q4) had a 1.74-fold increased risk of all-cause mortality (Model 3: HR = 1.74, 95%CI 1.30–2.32, P < 0.001) and a 1.87-fold increased risk of cardiovascular mortality (Model 3: HR = 1.87, 95%CI 1.12–3.13, P = 0.020). There was a ‘J’-shaped nonlinear relationship between the inflammatory score and all-cause mortality (P for nonlinearity = 0.001), and a marginally significant ‘J’-shaped relationship with cardiovascular mortality (P for nonlinearity = 0.057). The threshold points of the inflammatory score for adverse outcomes were - 0.643 and - 0.621, respectively.

Conclusion

The inflammatory score is independently associated with increased all-cause and cardiovascular mortality in patients with MetS, and risk stratification of these patients using inflammatory scores may provide specific therapeutic strategies to improve their prognosis.
Spotlight on pro-inflammatory chemokines: regulators of cellular communication in cognitive impairment
Authors: Wang Chenxu , Wang Jiayi , Zhu Zhichao , Hu Jialing , Lin Yong
Published: July 2024

Cognitive impairment is a decline in people’s ability to think, learn, and remember, and so forth. Cognitive impairment is a global health challenge that affects the quality of life of thousands of people. The condition covers a wide range from mild cognitive impairment to severe dementia, which includes Alzheimer’s disease (AD) and Parkinson’s disease (PD), among others. While the etiology of cognitive impairment is diverse, the role of chemokines is increasingly evident, especially in the presence of chronic inflammation and neuroinflammation. Although inflammatory chemokines have been linked to cognitive impairment, cognitive impairment is usually multifactorial. Researchers are exploring the role of chemokines and other inflammatory mediators in cognitive dysfunction and trying to develop therapeutic strategies to mitigate their effects. The pathogenesis of cognitive disorders is very complex, their underlying causative mechanisms have not been clarified, and their treatment is always one of the challenges in the field of medicine. Therefore, exploring its pathogenesis and treatment has important socioeconomic value. Chemokines are a growing family of structurally and functionally related small (8–10 kDa) proteins, and there is growing evidence that pro-inflammatory chemokines are associated with many neurobiological processes that may be relevant to neurological disorders beyond their classical chemotactic function and play a crucial role in the pathogenesis and progression of cognitive disorders. In this paper, we review the roles and regulatory mechanisms of pro-inflammatory chemokines (CCL2, CCL3, CCL4, CCL5, CCL11, CCL20, and CXCL8) in cognitive impairment. We also discuss the intrinsic relationship between the two, hoping to provide some valuable references for the treatment of cognitive impairment.
Behavioral hotspots of bottlenose dolphins in industrialized ship channels
Authors: Mills Eliza M. M. , Piwetz Sarah , Orbach Dara N.
Published: July 2024

Anthropogenic activity in coastal areas can damage marine habitats and alter marine mammal behavior and habitat use. Understanding behavioral associations with diverse habitat features in industrialized coastal areas is crucial for marine mammal conservation management. A shore-based digital theodolite was used to assess the behavioral states and habitat use of common bottlenose dolphins (Tursiops truncatus) off Port Aransas, Texas across seasons. The relationship between behavioral states and environmental and geographical variables were analyzed. Behavioral hotspots were identified. Dolphins frequently foraged (46%), indicating the area is an important feeding ground. Dolphins also traveled (25%) and milled (22%), with less frequent occurrences of socializing (6%) and resting (1% of observations). Season, time of day, and distance to shoreline were significant predictors of foraging and traveling behavioral states. Dolphins engaged in all behavioral states closer to seawall shorelines than to mangroves and natural seagrass beds, suggesting that hard shoreline features may influence daily activity patterns. Despite daily anthropogenic operations, bottlenose dolphins use features of the industrialized area (i.e., deeply dredged channels, human-engineered seawalls) to engage in a variety of behaviors. Monitoring of dolphin behavioral states and habitat use in active ship channels are needed to assess changes from baseline data from increasing coastal development and vessel activities.
Factors impacting the timing of reproductive development in female Antarctic krill at the northwestern Antarctic Peninsula
Authors: Steinke Kirsten B. , Bernard Kim S. , Reiss Christian S. , Walsh Jennifer , Correa Giancarlo M. , Stammerjohn Sharon E.
Published: July 2024

The northwestern Antarctic Peninsula is an important spawning, recruitment, and overwintering ground for Antarctic krill. The region is warming rapidly, and the current impacts of climate and environmental variability on the reproductive cycle of krill remain unclear. Here, we examine the reproductive stage of female krill in the austral winter from 2012 to 2016 in relation to climate and environmental data to assess what factors influence the timing of reproductive development. We observed significant interannual variability in the degree of maturation in female krill, ranging from 48% of female krill measured at a station in 2016 to a maximum of 94% of female krill measured at a station in 2014. On average, across all five years, three-quarters of the female krill sampled were in the stage known as previtellogenesis, the point at which the onset of sexual maturity begins. The preceding spring, summer, and autumn Southern Annular Mode and the Multivariate El Niño Index explained most of the variance in the data and indicated a strong, preconditioning storm-related effect on environmental conditions leading up to winter, affecting krill maturation status at the end of the winter season. Results from our study can be used to improve krill population models that are necessary for the management of the krill fishery and for conservation at the northwestern Antarctic Peninsula.
Optimization of liquid cooled heat dissipation structure for vehicle energy storage batteries based on NSGA-II
Authors: Sun Guanhua , Peng Jinzhao
Published: July 2024

Introduction: With the development of the new energy vehicle industry, the research aims to improve the energy utilization efficiency of electric vehicles by optimizing their composite power supply parameters.

Methods: An optimization model based on non-dominated sorting genetic algorithm II was designed to optimize the parameters of liquid cooling structure of vehicle energy storage battery. The objective function and constraint conditions in the optimization process were defined to maximize the heat dissipation performance of the battery by establishing the heat transfer and hydrodynamic model of the electrolyzer.

Results: The results showed that the optimization method had excellent performance on multiple evaluation indicators, the material degradation rate after optimization was reduced by 42%, the corrosion rate was reduced by 36%, and the battery life was increased by 17%. The optimization method ensured the maximum temperature control for the safe operation of the lithium-ion battery pack. The temperature of the battery pack was effectively controlled. The temperature difference was kept within 5°C, preventing the battery from overheating and extending its service life.

Discussion: The proposed liquid cooling structure design can effectively manage and disperse the heat generated by the battery. This method provides a new idea for the optimization of the energy efficiency of the hybrid power system. This paper provides a new way for the efficient thermal management of the automotive power battery.
Unilateral severe gynecomastia in a 14 year-old adolescent with neurofibromatosis type 1 undergoing endoscopic mastectomy: a case report
Authors: Shang Fangjian , Xi Bo , Qiu Duojun , Chen Xin , Wang Yifang , He Meng , Liu Bo , Zhao Zengren
Published: July 2024

Gynecomastia can be caused by neurofibromas but has rarely been reported. The present case report describes the clinical appearance, diagnosis, and therapy of a rare combination of a 14 year-old adolescent male unilateral severe gynecomastia with NF-1 neurofibromatosis. In this particular case, we successfully performed minimally invasive surgery using endoscopic mastectomy, which not only resulted in a satisfactory appearance but also confirmed the presence of neurofibroma type 1 by detecting typical immunohistochemical indicators associated with the disease. Additionally, we analyzed the gene responsible for the disease, c.1431del: p. F477Lfs*21, based on the patient’s family history.