bluuebunny/crossref_metadata_2025 huggingface dataset:
Field Trips as Science Learning In Early Children
Authors: Ulfah Maulidya , Saifuddin Saifuddin , Khoirunnisa Khoirunnisa
Published: January 2023

ABSTRAK. Field trip merupakan salah satu metode pembelajaran yang memberi kesempatan kepada anak-anak untuk mengamati atau mengobservasi dan memperoleh informasi secara langsung dengan berbagai benda di sekitar anak. TK Nara Islamic School Kota Cirebon menerapkan metode field trip dalam mengembangkan kemampuan sains. Jenis peneliti ini menggunakan penelitian deskriptif kualitatif. Pemerolehan data berasal dari observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa field trip sangat efektif digunakan pada anak Taman Kanak-kanak karena anak dapat belajar secara langsung berbagai kejadian yang terjadi dan dapat merangsang anak untuk bertanya. Filedtrip diterapkan sesuai dengan perencanaan yang sudah dibuat. Pelaksanaan pembelajaran sains melalui kegiatan field trip diantaranya dengan memperkenalkan langsung anak ke alam. Anak dapat melihat, mendengar, merasakan, rasa dan menyentuh sesuai dengan yang distimulasi Pendidik. Anak juga dapat belajar secara langsung sehingga lebih mudah memahami. Keberhasilan penggunaan metode dalam pembelajaran sains melalui kegiatan field trip anak usia dini dapat teramati dengan hasil penilaian anak berkembang sesuai harapan dalam aspek memecahkan masalah dan berpikir logis.Kata Kunci:  Anak usia dini, metode field trip, pembelajaran sains ABSTRACT. Field trips are one of the learning methods that provide opportunities for children to observe or observe and obtain information directly with various objects around the child. TK Nara Islamic School Cirebon City applies the field trip method in developing scientific skills. This type of research uses descriptive qualitative research. Data acquisition comes from observation, interviews, and documentation. The results show that field trips are very effective for Kindergarten children because children can learn directly about various events that occur and can stimulate children to ask questions. Filedtrip is applied according to the plan that has been made. Implementation of science learning through field trip activities, including by introducing children directly to nature. Children can see, hear, feel, taste and touch according to what is stimulated by the educator. Children can also learn directly so that it is easier to understand. The success of using the method in learning science through field trip activities for early childhood can be observed with the results of the assessment that children develop according to expectations in the aspect of solving problems and thinking logically.Keyword: early childhood, field trip methods, learning science
Ambidestria contextual frente as inovações disruptivas: o caso de um contact center
Authors: Silveira Saito Lígia Maria , Domingues Carlos Roberto
Published: January 2023

Objetivo: Analisar como as respostas estratégicas de um negócio maduro (Contact Center) levaram ao desenvolvimento da ambidestria contextual em um cenário de inovação disruptiva.
Originalidade/Relevância: A ambidestria organizacional tem sido objeto de diferentes estudos, quando a organização se torna capaz de equilibrar ações estratégicas de naturezas distintas e conflitantes com importantes avanços, mas, há espaço para discutir desafios e aspectos relacionados à ambidestria contextual (Rainsch & Birkinshaw, 2008; Brun, 2016) no cenário brasileiro.
Método: Abordagem qualitativa e uso do estudo de caso único, coleta de dados por meio de entrevistas semiestruturadas, formulário e grupo focal com gestores e participantes da equipe de trabalho, garantindo a triangulação de dados. Para análise foi utilizada técnica de análise de conteúdo.
Resultados: Aumentou a agilidade de resposta à inovação disruptiva e aumento do grau de exigência dos consumidores, também houve resistência às mudanças empreendidas que precisa ser melhor observada pelos gestores. Ocorreu desenvolvimento da ambidestria contextual com construção de contexto comportamental de alto desempenho, com enfoque ainda desequilibrado entre desempenho e suporte social.
Conclusões: Apesar do estímulo à criação de contexto de alto desempenho, a empresa não foi capaz de garantir a capacidade de ambidestria contextual da organização como um todo.
Pryamoye mass-spektrometricheskoye profilirovaniye meningiom: intraoperatsionnyy monitoring na osnove onkometabolov
Authors: Бормотов Д. С. , Шамраева М. А. , Кузин А. А. , Шамарина E. В. , Елиферов В. А. , Силкин С. В. , Жданова Е. В. , Пеков С. И. , Попов И. А.
Published: January 2023

Osnovnoy metod lecheniya meningiom na pervom etape yavlyayetsya neyrokhirurgicheskim vmeshatel'stvom s ostorozhnost'yu. Dlya rassmotreniya polnoty rezektsii v nastoyashcheye vremya razrabatyvayutsya razlichnyye podkhody k intraoperatsionnoy diagnostike, v chastnosti, opirayushchiyesya na printsipy molekulyarnogo profilirovaniya. Ustanovlennyye na mass-spektrometrii s pryamoy ionizatsiyey, takiye metody realizuyut svoyu effektivnost' na razlichnykh vidakh opukholey, odnako osobennosti molekulyarnoy struktury i mekhanicheskiye kharakteristiki meningiom ne pozvolyayut effektivno translirovat' protokoly, razrabotannyye dlya drugikh nozologiy. Tsel'yu raboty bylo primeneniye sravneniya vozmozhnostey trekh metodov pryamoy ionizatsii dlya issledovaniy obraztsov meningiom: metod pryamogo spreya tkani, metod kartridzhnoy ekstraktsii i metod ionizatsii s poverkhnosti sfericheskogo probootbornika. Dlya etogo analizirovali lipidnyy i metabolicheskiy profil' tkaney s meningiom, issechennykh v khode planovogo neyrokhirurgicheskogo vmeshatel'stva. Bylo prodemonstrirovano, chto dlya analiza primeneniya lipidnykh molekul molekulyarnogo profilya optimal'nym dlya klinicheskogo primeneniya yavlyayetsya metod kartridzhnoy ekstraktsii, otlichayushchiysya naiboleye prostoy realizatsiyey i vysokoy informativnost'yu. Dlya analiza onkometabolov s maloy molekulyarnoy massoy yavlyayetsya luchshim vyborom metoda ionizatsii poverkhnosti sfericheskogo probootbornika, dostizheniyem vysokoy chuvstvitel'nosti i nailuchshey proizvoditel'nost'yu mass-spektrometricheskogo kompleksa.
Avaliação dos impactos sociais oriundos da interiorização da Universidade Federal do Ceará (UFC)
Authors: Andriola Wagner , Suliano Daniele
Published: January 2023

Relata os principais resultados de estudo avaliativo sobre os impactos da presença da Universidade Federal do Ceará (UFC) em municípios do interior do estado, após a adesão desta ao Programa de Apoio a Planos de Reestruturação e Expansão das Universidades Federais (Reuni). Para tal, realizou-se pesquisa descritiva (ex-post facto) com 129 docentes e 503 discentes dos três campi avançados da UFC, nos municípios de Sobral, de Quixadá e da Região do Cariri (Juazeiro do Norte, Crato e Barbalha), e com 191 moradores locais. Os questionários destinados aos docentes e aos discentes foram autoaplicados, isto é, distribuídos aos respondentes para que estes os preenchessem de modo individual e, posteriormente, devolvidos aos auxiliares de pesquisa. Com os moradores locais, empregou-se roteiro semiestruturado de entrevista, aplicado de modo individualizado. Os resultados obtidos com as audiências estudadas (alunos, docentes e moradores locais) nos três campi convergiram para a aceitação de que a UFC causou impactos sociais positivos nos municípios cearenses do interior, dentre os quais: maior dinamização econômica local, implicando crescimento municipal; maior oportunidade de a população local contar com novas formas de qualificação profissional por meio do acesso à UFC; geração de mais postos de trabalho para os moradores locais.
Materiais e estratégias didáticas em ambiente virtual de aprendizagem
Authors: Lacerda Andreson , Silva Tatiana
Published: January 2023

Discute as bases teóricas e metodológicas da elaboração de material didático para uma disciplina presencial de Física Básica, no âmbito da graduação, em um ambiente virtual de aprendizagem (AVA), assim como a integração deste enquanto ferramenta de apoio ao ensino presencial. A área da Física possui variados recursos digitais, disponíveis em rede, para serem utilizados no processo de ensino-aprendizagem. Tais possibilidades estão baseadas em pesquisas e relatos de experiências que têm resultado em melhorias na aprendizagem e em potencialidades de abordagem de conceitos e temas dessa área do conhecimento. Assim, propõe-se integrar nossos olhares àqueles já lançados para esses recursos disponíveis em rede, a fim de pensá-los na perspectiva do design instrucional (DI), que vem auxiliar na estruturação de conteúdos, na sugestão da maneira mais adequada para sua apresentação e na união com atividades de aprendizagem elaboradas e implementadas por meio das ferramentas do AVA. Os resultados mostram que, do ponto de vista dos alunos, o AVA desenvolvido atende aos objetivos pretendidos porque complementa as discussões em sala, diversifica o conteúdo e atende a diferentes estilos de aprendizagem.
O espelho do gestor escolar do ensino público: relação de poder e governamentabilidade
Authors: Ferreirinha Isabella
Published: January 2023

Analisa o discurso do gestor escolar no contexto político-administrativo-pedagógico de escolas públicas de ensino fundamental do Brasil. Para tanto, toma-se como referência a prosa de Clarice Lispector, sobretudo seu conceito de instante-já, e as proposições de Michel Foucault quanto à relação entre poder e governamentabilidade. Objetiva demonstrar, por meio de pesquisa qualitativa, a multiplicidade das imagens-discurso de gestores no exercício da gestão escolar, utilizando-se da metáfora do espelho, em que estariam representadas. A coleta de dados foi realizada mediante entrevista semiestruturada junto a uma população composta por 17 gestores de escolas do primeiro e do segundo segmentos do ensino fundamental de um município de Santa Catarina. As reflexões apresentadas ao longo do texto subsidiam novas abordagens e ações sobre a gestão escolar no âmbito do ensino e do governo municipal. Os resultados obtidos apresentam uma alternativa para repensar a gestão escolar sob o prisma da estrutura teórica foucaultiana.
Recortes históricos sobre a noção de schème em Piaget: o processo de desenvolvimento de um conceito
Authors: Carvalho Júnior Gabriel , Parrat-Dayan Silvia
Published: January 2023

Apresenta o resultado de uma pesquisa realizada nos Archives Jean Piaget sobre o modo com que Piaget se valeu do conceito de schème ao longo de sua obra. Para tanto, foram investigadas as diversas fases da produção piagetiana à luz desse conceito, apresentado no livro Biologie et connaissance , para se fazer uma leitura tanto retrospectiva quanto prospectiva com base na hipótese central de que, mesmo de forma subjacente, Piaget utilizava elementos ligados a esse conceito em suas explicações. A partir do estudo realizado, foi possível estabelecer três características principais para os schèmes que, mesmo não sendo formalmente tematizadas em todas as fases do trabalho de Piaget, estavam presentes nas explicações do sujeito em situação. Indica, por fim, implicações didáticas da concepção de schème , inclusive com a explicitação de trabalhos recentes que utilizam tal noção para estudar o processo de construção de conceitos científicos.
Educação não escolar como campo de práticas pedagógicas
Authors: Lima Severo José
Published: January 2023

Apresenta considerações acerca do conceito de educação não escolar (ENE) e, a partir delas, estabelece contribuições críticas ao debate que envolve o reconhecimento e o fortalecimento dos processos educativos que se inserem nesse âmbito, sob o entendimento da pedagogia como ciência da educação capaz de imprimir sentidos pedagógicos nesses processos. Admitindo a existência de dimensões formativas intrínsecas a diferentes relações e processos sociais influenciados por uma nova racionalidade educativa contemporânea, discute a perspectiva da sociedade pedagógica e da aprendizagem ao longo da vida, o lugar da ENE quanto às categorias descritivas do fenômeno educacional e os aspectos que a configura como cenário de práticas pedagógicas fundadas pela práxis da pedagogia.
Perfil dos alunos internos no ensino profissional agrícola federal mantido pelo Ministério da Agricultura em Sergipe (1934-1967)
Authors: Conceição Joaquim
Published: January 2023

Aborda historicamente a condição socioeconômica dos alunos assistidos no internato da instituição de ensino profissional agrícola mantida pelo Ministério da Agricultura no estado de Sergipe, no período de 1934 a 1967. A operação historiográfica seguiu separando, reunindo e transformando em documentos históricos as informações coletadas. Foram manejadas fontes diversas, como relatórios, livros, imagens fotográficas, legislação, jornais e relatos de memórias. A pesquisa, recepcionando as contribuições de trabalhos sobre a história do ensino agrícola, procurou compreender o internato como uma marca significativa do ensino agrícola. Transparece, no decorrer do período pesquisado, especialmente da década de 1930 a meados de 1950, uma dualidade de atuação da instituição: a formação profissional agrícola e o assistencialismo mediante o internato público e gratuito.
Relações entre as representações sociais sobre o estudo e o desempenho na Prova Brasil
Authors: Koga Viviane , Rosso Ademir
Published: January 2023

Investiga as representações sociais (RS) dos alunos do 9º ano sobre o estudo com base em sua abordagem estrutural e nos subsídios fornecidos pela Psicologia e Epistemologia Genética. A coleta de informações foi realizada mediante a aplicação de questionário (N=213), solicitando que os alunos evocassem palavras ou expressões relacionadas ao termo indutor “estudar é” e justificassem a expressão listada como a mais importante. As evocações foram analisadas com o auxílio dos softwares Evoc, e as justificativas, pela análise de conteúdo. Os resultados revelaram que os alunos possuem uma representação ambivalente sobre o estudo, o qual é visto ora de forma positiva, como algo importante para o futuro; ora de forma negativa, caracterizado como chato e cansativo. Elevadas ou baixas, as médias de desempenho na Prova Brasil estão associadas ao tempo dedicado ao estudo, ao hábito de estudar e ao controle escolar e familiar do estudo. Nas duas situações foram identificadas atitudes heterônomas e representações hegemônicas sobre o estudo, de modo que os desempenhos na Prova Brasil não se traduzem em uma maior autonomia no estudo nem em uma compreensão mais positiva deste.
Jogo tradicional-popular e aprendizagem: uma análise teórica das comunicações dos jogadores
Authors: Cruz Rodrigo Wanderley , Gomes-da-Silva Pierre , Magno Ribas João
Published: January 2023

Objetiva estabelecer dupla abordagem teórica sobre a comunicação no jogo. Para tal, propomos a praxiologia motriz, com o fim de analisar a lógica interna do jogo, e a pedagogia da corporeidade, com sua analítica existencial do movimento, para compreender o modo de agir dos jogadores. Na especificidade das abordagens, o jogo tradicional-popular recebeu uma análise objetivo-funcional e subjetivo-cultural das ações dos jogadores em sua interação com o ambiente do jogo. Assim, neste ensaio analítico-propositivo, o jogo foi apresentado como situação de movimento privilegiada para os processos de ensino-aprendizagem na escola.
Awareness, attitude, and behavior regarding the use of proton pump inhibitors among healthcare providers, Al-Ahsa, Saudi Arabia
Authors: Bohamad Abdullah , Alamer Mohammed , Ali Hatem , Albash Latifah , Buali Hadeel , Ali Mahdi , Essa Abdallah
Published: January 2023

Objective: This study aimed to assess knowledge, attitude, and behavior of using proton pump inhibitors (PPIs) among healthcare providers.
Methods: This was a cross-sectional study conducted in Al-Ahsa, Saudi Arabia between March and June, 2022 using a self-administrated questionnaire and including 300 medical professionals. Saudi healthcare providers, male or female, were included in this study. The questionnaire covered demographics, awareness, attitude, and behavior related to the use of PPIs.
Results: According to the results, out of 300 participants, 33.1% were physicians, 33.4% were nurses, and 33.4% were pharmacists. Pharmacists demonstrated the greatest level of knowledge. Most participants (81.3%) answered that the main cause of PPI overuse was doctors, while others (18.7%) answered patients. The findings revealed that nurses, those who had bachelor's degrees, and those who were between the ages of 25 and 40 years, and who worked in primary healthcare had less knowledge.
Conclusion: Medical professionals of Al-Ahsa were aware about the use of PPIs. Raising their level of knowledge and reducing their dependency on PPIs are necessary. The widespread abuse of PPI must be reduced by regular professional development programs and training for healthcare professionals.
Case report of 16-year-old male with tubulointerstitial nephritis with refractory uveitis in Saudi Arabia
Authors: Malik Fatima , Alabdulsalam Abdulrahman , Moalwi Samiah , Alshehri Abdulrahman , Almutairi Faisal , Almutairi Talal , Alshehri Ahmad
Published: January 2023

Background: Tubulointerstitial nephritis with uveitis (TINU) syndrome is a condition characterized by uveitis with tubulointerstitial nephritis in the absence of another systemic condition.
Case Presentation: We report a case of a 16-year-old boy referred to our hospital due to elevated renal function and a 7-day history of unilateral eye congestion. An ophthalmologist made the diagnosis of left eye anterior uveitis. The diagnosis of acute kidney injury was made. A renal biopsy was obtained and showed tubulointerstitial nephritis with granulomatous inflammation and foreign body giant cell reaction. The patient improved after initiating corticosteroid therapy with a tapering dose.
Conclusion: TINU syndrome is a rare clinical condition that can present unusually and can be misdiagnosed. Hence, physicians should be familiar with this condition to diagnose it and start proper treatment without delay. The patient should follow up with ophthalmologists, nephrologists, and primary physicians for a better treatment outcome. The outcome is usually excellent with treatment, but some patients may have recurrent uveitis.
Traumatic bone cyst of the mandible: a case report
Authors: Othman Ahmad , Zaki Hattan , Ka’aki Muhannad , Alsaedi Rahaf , Almukhlifi Rahaf , Aljohani Rahaf
Published: January 2023

Background: Traumatic bone cyst (TBC) is defined as a non-neoplastic osseous lesion and is considered a pseudocyst since it lacks an epithelial lining. There is a lack of understanding of the etiology and pathogenesis of this lesion. About 90%-95% of TBC cases involve the metaphysis of long bones. This article presented a case of TBC in the mandible.
Case Presentation: A 21-year-old male patient was presented with no history of trauma. Intra-oral examination revealed normal soft tissue. The lesion was asymptomatic and the teeth in the affected area responded normally to the vitality test. Orthopantomograph showed a well-defined unilocular radiolucent lesion, altered bone trabeculations with slightly increased bone density from the distal root of tooth # 46 to the distal root of tooth # 48, and mild thinning of the inferior mandibular borders. Cone-beam computed tomography showed a well-defined periapical lesion with a scalloping border around the roots at the same site and the inferior alveolar canal was displaced. The patient was draped and prepared for an incisional biopsy. A scant soft tissue and fragment of bony material were sent for histopathological examination to confirm the diagnosis. Microscopic examination of the specimen revealed a fragment of vital trabecular bone surrounded by fibrovascular connective tissue, and areas of hemorrhage were also observed that were managed by surgical curettage. Osseous regeneration was reported after 12 months of follow-up.
Conclusion: Swelling of the mandible without symptom in a young patient, with or without a trauma history would rise the suspension of a solit ary bone cyst.
مضامين سلاسل الرسوم المتحركة إزاء نقد المشكلات الاجتماعية في العراق "دراسة تحليلية"
Authors: Fadel Ali Mouloud
Published: January 2023

تحددت مشكلة البحث في الإجابة على تساؤل رئيس مفاده: ما مضامين سلاسل الرسوم المتحركة ازاء نقد المشكلات الاجتماعية في العراق، والذي يهدف إلى معرفة مضامين تلك الرسوم المتحركة التي قدمتها فضائية الشرقية، ونقدت من خلالها بعض المشكلات الاجتماعية في العراق. واتخذ من المنهج المسحي، وبشقيه الوصفي والتحليلي منهجا لدراسة ذلك، من خلال اداة تحليل المضمون لعينة قصدية قوامها (87) تمثلت في "العتاك1، وحبزبوز، وشلش من حي التنك" بواقع (29) لكل سلسلة من هذه السلاسل، وذلك للمدة من 1 نيسان وحتى 31 آب 2021. وقد توصل البحث إلى عدة نتائج من أهمها: جاءت مضامين سلاسل الرسوم المتحركة –عينة الدراسة- "ساخرة" في سلسلة "حبزبوز" بنسبة 83%، بينما جاءت "بأسلوبين معا" في سلسلة "العتاك1" بنسبة 72%، وحلت هذه المضامين "جادة" في سلسلة "شلش" بنسبة 10%، وقد استهدفت المضامين فئة "كبار السن" بنسبة 86% في سلسلة "شلش"، وبنسبة 72% في سلسلتي "العتاك، وحبزبوز". كذلك بينت النتائج تركيز سلسلة "شلشل" على مشكلة "التفكك الاسري" وذلك بنسبة 24%، بينما اهتمت سلسلة "العتاك" بمشكلة "الادمان"، وذلك بنسبة 17% من مضامينها، وركزت سلسلة "حبزبوز بنسبة 45% من مضامينها على مشكلة "الانحراف الاخلاقي"، كما بينت النتائج أن سلسلة "العتاك" قد اتخذت أساليب النقد "الرمزية –بالصور، والايماءات، والرسوم-" بنسبة 55% في مضامينها، ولجأت سلسلة "حبزبوز" إلى الأساليب "المادية –بالفعل-" بنسبة 14%، بينما سلسلة "شلش" قد اتخذت أساليب "لغوية –بالقول-" بنسبة 41% من مضمونها.  الكلمات المفتاحية: الرسوم المتحركة، السلاسل، مضامين، المشكلات، نقد.
اهمية واستخدام التعليم المدمج في تصميم وتطوير دروس الحاسوب في المرحلة الاعدادية من وجهة نظر مدرسي الحاسوب
Authors: AASI ABUDULSATTAR SALEH
Published: January 2023

هدفت الدراسة إلى التعرف على "أهمية واستخدام التعليم المدمج في تصميم وتطوير دروس الحاسوب في المرحلة الاعدادية من وجهة نظر مدرسي الحاسوب".
ولتحقيق أهداف الدراسة استخدم الباحث المنهج الوصفي، وتم تطبيق مقياس أهمية واستخدام التعليم المدمج على عينة عشوائية قوامها (39) مدرساً ومدرسه من مدرسي ومدرسات الحاسوب في المرحلة الإعدادية بمحافظة صلاح الدين، وتم استخدام المتوسطات الحسابية الحساب درجة اهمية واستخدام التعليم المدمج لدى معلمي ومعلمات المرحلة الاعدادية، كما تم استخدام اختبار (ت) للتعرف على درجة الفروق والتي تعزي لمتغير الجنس والمتغير الاكاديمي. وتوصلت الدراسة إلى النتائج التالية: إن اتجاهات التعلم المدمج لدى مدرسي ومدرسات المرحلة الاعدادية بمحافظة صلاح الدين جاء بدرجة متوسطة بشكل عام وبمتوسط حسابي (3,72). كما جاءت درجة فروق اتجاهات مدرسي ومدرسات الحاسوب نحو اهمية واستخدام التعليم المدمج في تصميم وتطوير دروس الحاسوب تبعاً لمتغير الجنس بمتوسط حسابي (3,72) للمدرسين و(3,73) للمدرسات. جاءت درجة فروق اتجاهات مدرسي ومدرسات الحاسوب نحو اهمية واستخدام التعليم المدمج في تصميم وتطوير دروس الحاسوب تبعاً لمتغير الاكاديمي بمتوسط حسابي على التوالي لكل من (كلية التربية وكلية العلوم) (3,72). وفي ضوء ما توصلت إليه الدراسة من نتائج، أوصى الباحث بالتأكيد على أهمية استخدام تكنولوجيا التعلم في التدريس، وضرورة اهتمام المسؤولين في وزارة التعليم بتشجيع وحث المدرسين والمدرسات في بناء البرامج التعليمية المحوسبة المعتمدة على التعلم المدمج، وكذلك توعية أولياء الأمور بأهمية التعلم المدمج وتأثيره في عملية التعليم والتعلم وتحقيق نواتج إيجابية باستخدامه.
Fundamentals of the Legislation of the Union SSR and the Union Republics in the Centralization of the Legislative Space of the USSR (the Second Half of the 1950s - 1970s)
Authors: Kodan Sergei Vladimirovich
Published: January 2023

The problem of centralization and formation of a single legislative space in the USSR was one of the directions of maintaining the unity of the Soviet Union state. Even during the creation and the first years of the RSFSR's existence in the first Soviet Federal Republic, this issue was among the priorities in the policy of the RCP (b) and the Soviet state, which considered the "revolutionary codification" of Soviet legalizations as the main means of forming "proletarian legality and law and order". Already the first codes of the RSFSR laid down a steady trend of using the systematization of legislation to create a single regulatory space in the conditions of the Soviet socialist federation. With the creation of the USSR in 1922, the issue of coordinating and ensuring the unity of legislative activity and legislation within the USSR was actualized due to the presence of their own legislation in the Union republics and the need to streamline approaches to legal regulation within the Union and republican legal space. In this regard, the second half of the 1950s was a period of increasing the level of legislative centralization through the use of the Fundamentals of the Legislation of the USSR and the Union Republics as an instrument of unification and the creation of single approaches to sectoral legal regulation in the USSR. The scientific novelty of the article is that the analysis of the phenomena under consideration and the main conclusions allow us to talk about a new stage in the creation of sufficiently effective mechanisms to ensure the unity of the legislative space as one of the main elements of the unity of the USSR as a federal state as a whole.
Economic Feasibility Analysis of Fishing Job Operation in Well YS13
Authors: Muhammad Ariyon  , Bella Santika  , Fitrianti
Published: January 2023

Oil consumption in Indonesia has increased from year to year. However, the increasing demand for oil and natural gas is inversely proportional to oil and gas production, which always declines from year to year. One of the factors causing the decline in production is the well damage. Well YS13 is a well that is damaged in the form of fish in the well. A fishing job is the most appropriate option to solve the problem of the presence of fish in the well because the fish in the well must be removed to continue well production activities or drilling activities. This study aimed to determine the economic feasibility of fishing job activities to be carried out at the YS13 well. The research begins with the preparation of the required data, then calculate the predicted production of the YS13 well with the decline curve method, estimates the cost of the fishing job, and economic fishing time (EFT). And determines the economic feasibility of the fishing job project by calculating profit indicators, namely Net Present Value (NPV), Internal Rate of Return (IRR), and Pay Out Time (POT). The results of calculations using the decline curve method obtained that the total production for 20 months is 4293.52 bbl. The EFT value is 3 days with Ps = 10% and the total cost of fishing is $28.657,70. The economic value of the project with discount rate = 12%, MARR = 12%, NPV = $147.367,20, IRR = 114%, and POT = 1.44. From the results of the calculation of the economic feasibility, the project is considered feasible to be carried out.
Control Structure On Damage Zone and Fault Plane to Geometry Of Quartz Veins and Calcite In Muaradua Ogan Komering Ulu Selatan, South Sumatra, Indonesia
Authors: Setiawan Budhi , Goestyananda Pratama
Published: January 2023

Geological mapping was carried out on the Gilas and Malau rivers in the Muaradua area, South Ogan Komering Ulu Regency, South Sumatra by observing the presence of joints, faults, and veins in the granite and phyllite rock outcrops of the Tarap Formation. Research on pattern geometry and vein type in the crushing zone is focused on measuring the direction (trend) of veins and joints. The measurement results are then analyzed to obtain a general pattern of quartz and calcite veins so that the orientation of their development can be known. The method used in this study is in the form of determining the orientation and geometry of the veins based on classifications that refer to several studies, then an analysis is carried out using DemNAS data to determine the general direction of the straightness pattern of the study area. The quartz veins that developed in the study area have an extensional fracture type with the geometry found in the form of isolated, abutting, cutting, mutually-cutting, and crosscutting. The veins that develop in the research area are relatively north-south and west-east and indicated the presence of a fault and traces of deformation that occurred in the study area. With the help of veins and joints found in the study area, it is possible to determine the structural control of the presence of a crushing zone in the fault plane.
Clinical heterogenity of Russian children with a CRB2 gene defect
Authors: А.М. Милованова, , Т.В. Вашурина, , П.В. Ананьин, , А.А. Пушков, , А.Н. Цыгин, , К.В. Савостьянов, , А.Ю. Асанов,
Published: January 2023

Нефротический синдром, вызванный нуклеотидными вариантами в гене CRB2, является редким и недостаточно хорошо изученным состоянием. На настоящий момент существует лишь несколько сообщений об этой патологии и нет ни одного описания мягкого течения заболевания. Целью настоящего сообщения является демонстрация фенотипических особенностей нефротического синдрома, вызванного мутациями в гене CRB2, и обоснование дальнейшего изучения его генетических причин. На базе нефрологического и молекулярно-генетического отделений ФГАУ «НМИЦ здоровья детей» проведено ретро- и проспективное исследование генетических причин первичного стероидрезистентного нефротического синдрома (СРНС), включившее 250 детей. Среди 250 детей лишь двое имели причинные нуклеотидные варианты в гене CRB2 (0,8% от всех детей с СРНС и 1,21% от детей с выявленными генетическими причинами СРНС). Дети имели разные течение болезни и выраженность экстраренальных проявлений. Выводы: нефротический синдром, вызванный мутациями в гене CRB2, является чрезвычайно редкой патологией. Нами описано два случая с абсолютно разным клиническим течением.

Nephrotic syndrome (NS) with variants in the CRB2 gene is a rather rare condition, and there are only a few reports of its severe course and no one of mild one. The aim of the communication is to demonstrate the phenotypic features of nephrotic syndrome caused by mutations in the CRB2 gene. On the basis of the nephrological and molecular-genetic departments of the Federal State Autonomous Institution “National Medical Research Center of Children’s Health” we performed retro- and prospective study of the genetic causes of primary steroid-resistant nephrotic syndrome, included 250 children. Among 250 children, only two had causative nucleotide variants in the CRB2 gene (0.8% of all children with steroid-resistant and 1.21% of children with identified genetic causes of SRNS). Children had a different course of the disease and the severity of extrarenal manifestations
Achieving a full-color palette with thickness, temperature, and humidity in cholesteric hydroxypropyl cellulose
Authors: Ren Hongning , Balcerowski Tadeusz , DUMANLI Ahu Gümrah
Published: January 2023

Hydroxypropyl cellulose (HPC) is a sustainable, cost-efficient, and bio-compatible cellulose derivative that forms cholesteric liquid crystalline phases in highly concentrated water solutions. While there have been studies exploiting HPC’s structural coloration and transferring the cholesteric order of the solutions into solid form via cross-linking and heat treatments, there is still a lack of understanding of the mechanisms that enable the transfer of the structural ordering of the HPC at high temperatures. In this work, we demonstrate the balance between temperature, humidity, and film thickness to achieve a full-color palette of pure HPC. While the cholesteric phase is trapped by water evaporation, the formation of a dense skin on the gels enables a thermal expansion of the encapsulated HPC gel during the heat treatment. Increasing the thickness, applying higher curing temperatures, and exposing the samples to higher humidity during the evaporation all result in increased pitch values that cause a red shift in coloration in the solid state. Our analysis of the HPC samples cured in controlled temperature and humidity conditions at a fixed thickness provided an understanding of the dominance of the thermal expansion which drives the final structural organization in the solid cholesteric phase. When the thickness of the films was varied against fixed temperature and humidity conditions, the color shift from red to violet follows the thickness gradient of the sample due to the change in the curing time required to reach the solid form.
Cleavage of the Au−P Bond in Au-Substituted Phosphines
Authors: Wei Rui , Wang Xin-Feng , Liu Liu Leo
Published: January 2023

Three protocols that involve the cleavage of the Au−P bond in Au-substituted phosphines (AuPhos) have been demonstrated, namely i) direct demetallation with a strong anionic base; ii) protonation followed by demetallation with a neutral base; iii) oxidation-triggered metal migration. Specifically, direct demetallation of (CAAC)AuPPh2 (1a) (CAAC = cyclic (alkyl)(amino)carbene) with KP(TMS)2 or LiC(N2)TMS yields (CAAC)AuPTMS2 (2) or (CAAC)AuC(N2)TMS (3), respectively. Treatment of (NHC)AuPPh2 (1b) (NHC = N-heterocyclic carbene) with HOTf followed by the corresponding neutral phosphine gives scarce examples of aurophosphonium salts [(NHC)AuPHAd2][OTf] (5) and [((NHC)Au)2PPh2][OTf] (6). Oxidation of 1a or 1b with Se affords LAuSeP(Se)Ph2 (L = CAAC, 7a; NHC, 7b).
Catalytic Dinitrogen Conversion to Secondary Silylamines using Bimetallic Titanium Aryloxides
Authors: Wong Anthony , Hernandez Matthew , Ochiai Tatsumi , Rao Guodong , Britt David , Kaltsoyannis Nikolas , Arnold Polly
Published: January 2023

A tetraphenolate-supported bimetallic Ti complex undergoes multiple two-electron reductions, the last of which leads to the reductive activation of dinitrogen. The inclusion of weak acid and silyl electrophiles during the reduction enables the catalytic conversion of N2 to purely secondary amines. Yields of up to 35.9 equivalents of amine per complex are produced under ambient conditions. The Zr analogue is also a competent catalyst. A detailed electron paramagnetic resonance (EPR) spectroscopic, crystallographic, and computational analysis of the reduced intermediates, and comparisons with the Zr analogues, helps explain the roles of the Group 4 metal, reductant, and ligand.
Highly Chemoselective Ligands for Suzuki–Miyaura Cross-Coupling Reaction Based on Virtual Ligand-Assisted Screening
Authors: Matsuoka Wataru , Harabuchi Yu , Nagata Yuuya , Maeda Satoshi
Published: January 2023

Ligand screening is a crucial step in the development of transition metal catalysis, as it involves identifying the optimal ligand for a particular reaction from a large pool of candidate molecules. Conventionally, this process is performed through a time-consuming and resource-intensive trial-and-error approach. One alternative strategy for streamlining this process is a transition state theory (TST)-based approach, which aims to design optimal catalysts using quantum chemical calculations. However, TST-based ligand screening can be impractical owing to the large number of ligands that need to be evaluated through quantum chemical calculations. In this study, we present a practical TST-based ligand screening method in accordance with our virtual ligand-assisted (VLA) screening strategy. Using the chemoselective Suzuki–Miyaura cross-coupling (SMC) reaction of p-chlorophenyl triflate as the target reaction, we identified the features of phosphine ligands that maximize chemoselectivity through VLA screening. Based on the obtained results, we successfully found several ligands with high chemoselectivity. Our results suggest that the VLA screening strategy could be a useful tool for ligand screening and catalyst design.
68 million natural product-like compound database generated via molecular language processing
Authors: Tay Wei Peng Dillon , Yeo Zhen Xi Naythan , Adaikkappan Krishnan , Lim Yee Hwee , Ang Shi Jun
Published: January 2023

Natural products are a rich resource of bioactive compounds for valuable applications across multiple fields such as food, agriculture, medicine. For natural product discovery, high throughput in silico screening offers a cost-effective alternative to traditional resource-heavy assay-guided exploration of structurally novel chemical space. In this data descriptor, we report a characterized database of 68,113,839 natural product-like molecules generated using a recurrent neural network trained on known natural products, demonstrating a significant 167-fold expansion in library size over the currently estimated 406,919 natural products known. This study highlights the potential of using deep generative models to uncover novel natural product chemical space for high throughput in silico screening toward natural product discovery.
Spectrophotometric Measurement of Lithium in Human Saliva Using the Chromogenic Reagent Thorin
Authors: Levitt, MD, PhD Stephen Robert
Published: January 2023

This study explored the feasibility of using the chromogenic dye Thorin to spectrophotometrically measure the lithium concentration in human saliva. The absorbance wavelength maximum of the Li-Thorin complex was determined to be 480 nm. Lithium concentrations were measured spectrophotometrically at 480 nm in human pooled saliva with lithium added to produce calibration standards of 0.00-5.29 mEq/L of lithium, which corresponds to a blood lithium range of 0.00-2.60 mEq/L, assuming a saliva/blood ratio of 2/1. A least-squares fit of the absorbance vs lithium concentration calibration data produced a regression equation y = 0.128x + 1.449 with correlation coefficient = 0.997. This regression equation was then used to predict lithium concentrations from absorbance data in prepared lithium/saliva test solutions and in hospitalized patients being treated with lithium. The results generally agreed well with those determined by atomic absorption spectroscopy. By measuring absorbance of test saliva vs reagent blank containing the same amount of saliva, interfering effects of saliva protein and electrolytes in the test samples were avoided. This study supports the continued exploration of this method as a non-invasive point-of-care testing approach for monitoring saliva lithium during lithium treatment.
Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome
Authors: Watson James A , Pantier Raphaël , Jayachandran Uma , Chhatbar Kashyap , Alexander-Howden Beatrice , Kruusvee Valdeko , Prendecki Michal , Bird Adrian , Cook Atlanta G
Published: January 2023

Spalt-like 4 (SALL4) maintains vertebrate embryonic stem cell identity and is required for the development of multiple organs, including limbs. Mutations in SALL4 are associated with Okihiro syndrome, and SALL4 is also a known target of thalidomide. SALL4 protein has a distinct preference for AT-rich sequences, recognised by a pair of zinc fingers at the C-terminus. However, unlike many characterised zinc finger proteins, SALL4 shows flexible recognition with many different combinations of AT-rich sequences being targeted. SALL4 interacts with the NuRD corepressor complex which potentially mediates repression of AT-rich genes. We present a crystal structure of SALL4 C-terminal zinc fingers with an AT-rich DNA sequence, which shows that SALL4 uses small hydrophobic and polar side chains to provide flexible recognition in the major groove. Missense mutations reported in patients that lie within the C-terminal zinc fingers reduced overall binding to DNA but not the preference for AT-rich sequences. Furthermore, these mutations altered association of SALL4 with AT-rich genomic sites, providing evidence that these mutations are likely pathogenic.
ENTREVISTA A MARÍA GALINDO
Authors: Sánchez Miranda Bertha
Published: January 2023

María Galindo es fundadora del Movimiento de Mujeres Creando de Bolivia y quizá una de las feministas más radicales de América Latina. Lleva cerca de dos décadas viajando al Estado español para presentar algunos de sus trabajos. Estuvo hace unos meses en Zaragoza presentando su nuevo libro Feminismo Bastardo. La presentación del libro tuvo lugar en el Centro Social Luis Buñuel, al que asistieron más de un centenar de personas. Posterior a la presentación del libro, nos juntamos con ella un grupo de mujeres feministas migrantes. La mayoría procedentes de Latinoamérica y el Sáhara, con situación migratoria distinta que va desde mujeres nacionalizadas que llegaron hace décadas, hasta solicitantes de asilo político que llevan pocos inviernos en estas tierras. Esta entrevista a varias voces recoge parte de esa conversación íntima entre María Galindo y el grupo de migras, y las reflexiones que sacudieron el Luis Buñuel.
Decent Work Systems: Management Model Analysis on the Example of Russian Railways
Authors: Gileva K. V.
Published: January 2023

Decent work governance for modern socio-economic systems is a key goal and a common operating methodology. The current literature does not fully disclose the questions posed, which require the proposal of system management models, formed considering the factors of the external and internal environment that determine the characteristics of management in different sectors of the economy. The purpose of the paper is to update the modern provisions of the decent work theory, the formation of a basic model for managing decent working conditions and its substantive justification on the example of Russian Railways enterprises. For this purpose, the author describes the implementation research work using the methods of interdisciplinary analysis of literature and practical experience, as well as a regulatory framework, professional recruitment, including for the transport industry, strategic documents and concepts in responsible work. Also, the research used the method of counter modeling, which represents the decomposition of the theoretical model into the results of the production conditions, financial and socio-economic activities of a particular enterprise. As a result of the work carried out, the author built a model for managing suitable labor at the enterprise based on the scheme of suitable labor management, also relying on empirical data and the regulatory framework of Russian Railways. This model has become a methodological basis for analyzing the situation of decent labor management at the enterprises of Russian Railways. The data obtained testify to the operation of managerial, legal, supervisory, institutional and financial mechanisms for managing suitable work. The practice of applying the results of the study led both to positive results and identified problem areas that cause socio-economic risks in implementing personnel policy measures of Russian Railways.
On the Progressive Views on the Economic Entities’ Governance in Various Regions of the Globe
Authors: Marshev V. I. , Bogachev V. F. , Chernov S. E.
Published: January 2023

XXII International Conference on the History of Management Thought and Business “Development of views on regional Economic management in the countries of the world: History and modernity” was held on July 1 and 2, 2022 at the Faculty of Economics of Lomonosov Moscow State University. The event was announced in the informational paper of the journal “Management Sciences” [2022;12(1):96–98]. The participants at the conference were asked the following questions:

— Why did ideas and concepts of regional economic management arise and develop?

— How did the authors’ views of the concepts of regional governance differ and what were the factors and reasons for changing these views?

— Which way and what aspect languages (political, economic, socio-cultural, etc.) were measured and estimated the concepts and results of conflict governance in managing the economies of regions in various countries of the world?

— How and why did the views change on the staffing of regional economic management processes?

Over 90 people attended the conference (in online and offline forms) —  students, masters, graduate students, lecturers, scientists and practitioners from 6 countries. They had read 32 lectures and reports. This paper provides an analytical review of some of them.
Interaction of Public Authorities in Strategic Planning
Authors: Belyaev I. I. , Pobyvaev S. A. , Silvestrov S. N.
Published: January 2023

The relevance of the paper is determined by the authors’ intentions to solve the problems of national economic strategy to a greater extent than issues of purely academic interest, since the effectiveness of domestic strategic planning, despite the efforts actively made to organize this process, including in terms of legal regulation, is clearly insufficient. The principal method of research is the comparison of existing legislative provisions with each other, with elements of foreign experience and with the actual state of things, and their linking into a single logic. The authors analyzed system and tactical problems of the strategic planning and management, considering the involvement of public authorities in this process. System problems include the absence of both a hierarchy of documents and an analytical planning entity of high capacity, as well as a lack of performers’ competencies. Tactical problems include the unsatisfactory state of affairs at the municipal level and the overload of the strategic planning system of inferior quality documents. The primary task of the study is to determine the fundamental ways to resolve systemic and tactical problems. Separately, the authors highlight an importance of introducing the public authority legal category that is going to synchronize strategies of all its levels in the future. Based on the analysis of the internal logic of the development of a strategic planning and management system, as well as the best practices of foreign experience, the authors conclude that the state system of strategic audit. According to the results of the study, this system is inadequate to the tasks of effective implementation of the state strategy. Also, the authors concluded the need for digitalization of strategic planning to reconstruct existing connections, methods of interaction and the use of new, informational analysis methods. The practical significance of the research is determined by the possibility of applying the authors’ recommendations being in the normative regulation of the process of domestic strategic planning and management.
Modern Forms of Flexible Management Systems in Russia
Authors: Slavin B. B.
Published: January 2023

The paper considers modern forms of flexible organization’s management systems in Russia. The aim of the research is to study the necessity and features of flexible management systems use for self-organization of employees’ work, as well as the consequences of the transition from rigid hierarchies to flexible ones. The author solved the following tasks: he described the formation of a new employee and his political behavior; analyzed the new “shop” structures that have appeared in the Russian Federation and their struggle for social rights. The study described experiments of domestic companies with “turquoise” practices and revealed specific features of self-organization in Russia. Also, the author explored flexible methods used not just in management hierarchies but also to coordinate the implementation of projects, build information structures, as well as to organize the financing of innovations in organizations. The study used the method of comparative analysis of the existing practice of applying digitalization in the economy, as well as theoretical approaches to understanding its essence. As a result, it was shown that industrial enterprises caught in the digital transformation zone had to use flexible management practices for innovative development (at least in terms of their information systems development). Nevertheless, not all of them are universal and lead to increased efficiency. The paper reveals the role of a human factor as the most important component in the innovative company management, since self-organization and implementation of changes require special personality characteristics.