bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Factors of Central Venous Catheter-Related Bloodstream Infection for Continuous Renal Replacement Therapy in Kidney Intensive Care Unit Patients
Authors: Cheng Shuiqin , Xu Shutian , Guo Jinzhou , He Qunpeng , Li Aijuan , Huang Lixuan , Liu ZhiHong , Li Shijun
Published: November 2018

Background: The incidence of central venous catheter-related bloodstream infection (CRBSI) for continuous renal replacement therapy (CRRT) in kidney intensive care unit (ICU) patients is worthy of particular attention and recently, we analyzed clinical characteristics and risk factors of CRBSI for CRRT in our kidney ICU patients. Methods: To be part of this retrospective study, 1,523 patients who had a central venous catheter (CVC) for CRRT during the period April 2010 to May 2015 in our centre were enrolled. The clinical features and pathogens of CRBSI patients were investigated. Patients who also had CRRT of kidney ICU hospitalization without CRBSI were enrolled in a 1: 2 ratio as control. Risk factors of the CRBSI were analyzed. Results: A total of 57 patients had central venous CRBSI. The incidence of the infection was 3.7%. The mean rate of CRBSI was 3.9 per 1,000 catheter days, and the catheter median indwelling time was 14 (7–30) days. The most common pathogens were Gram-positive bacteria, which were noted in 29 cases (50.9%), followed by Gram-negative bacteria (36.8%). The most common pathogens causing CRBSI were Staphylococcus aureus (10 cases) and sewer enterobacteriaceae (10 cases) followed by Staphylococcus epidermidis (9 cases). CVC insertion sites included internal jugular vein (33 cases) and femoral vein (24 cases), accounting for 2.9% of internal jugular vein catheterization (1,140 cases) and 6.3% of femoral vein catheterization (383 cases) respectively. In total, 16, 20, 7 and 14 cases of CRBSI were noted in Spring, Summer, Autumn and Winter, accounting for 28.1, 35.1, 12.3 and 24.6% respectively. The most common infectious manifestations were chills (68.4%), fever (100%), and septic shock (49.1%). Multivariate analysis showed that catheterization of the femoral vein, long catheter indwelling time, low CD4+ lymphocytes and high acute physiology and chronic health evaluation (APACHE) II scores were independent factors associated with CRBSI. Conclusions: The incidence of CRBSI in our kidney ICU was 3.7%. Central venous CRBSI for CRRT was associated with catheterization of the femoral vein, long catheter indwelling time, compromised immune function and high APACHE II scores. Understanding pathogens and risk factors for central venous CRBSI in kidney ICU can help doctors prevent and treat CRBSI earlier.
Comprehensive Circular RNA Profiling Reveals the Regulatory Role of the CircRNA-0067835/miR-155 Pathway in Temporal Lobe Epilepsy
Authors: Gong Guo-Hua , An Feng-Mao , Wang Yu , Bian Ming , Wang Di , Wei Cheng-Xi 
Published: November 2018

Background/Aims: Temporal lobe epilepsy (TLE) is the most common form of adult localization-related epilepsy that is accompanied by progressive etiopathology and high incidences of drug resistance. Circular RNAs (circRNAs) play important roles in fine-tuning gene expression, however, the expression profile and clinical significance of circRNAs in TLE remains unknown. Methods: Circular RNA microarray was conducted to identify TLE-related circRNAs. CCK8 assays and flow cytometric assays were conducted to clarify the role of circRNA in TLE in vitro. Bioinformatics analysis and in vitro experiments were conducted to clarify the mechanism of circRNA-mediated gene regulation in TLE cell. Results: 586 differentially expressed circRNAs were identified between TLE and the control tissues. The expression of circRNA-0067835 was significantly down-regulated in tissues and plasma from TLE patients. Lower circRNA-0067835 correlated to increased seizure frequency, HS, and higher Engel’s score. Overexpression of circRNA-0067835 observably decreased SH-SY5Y cell proliferation by causing G1 arrest and promoting apoptosis. Bioinformatics online programs predicted that circRNA-0067835 acted as miR-155 sponge to regulate FOXO3a expression, which was validated using luciferase reporter assay. Conclusion: Our experiments showed that circRNA-0067835 regulated refractory epilepsy progression by acting as a sponge of miR-155 to promote FOXO3a expression, indicating that circRNA-0067835 may serve as a potential therapeutic target for patients with TLE.
The Long Noncoding RNA 150Rik Promotes Mesangial Cell Proliferation via miR-451/IGF1R/p38 MAPK Signaling in Diabetic Nephropathy
Authors: Zhang Yajuan , Sun Yan , Peng Rui , Liu Handeng , He Weihao , Zhang Luyu , Peng Huimin , Zhang Zheng
Published: November 2018

Background/Aims: Diabetic nephropathy (DN) as the primary cause of end-stage kidney disease is a common complication of diabetes. However, the initiating molecular events triggering DN are unknown. Recently, long noncoding RNAs (lncRNAs) have been shown to play important roles in DN. Methods: The expression level of lncRNA 1500026H17Rik (150Rik for short) was measured by qRT-PCR (quantitative real-time PCR). Cell proliferation ability was detected by 5-Ethynyl-2’-deoxyuridine (EdU). The relationship between 150Rik and microRNA 451 (miR-451) was examined by luciferase assay and RNA immunoprecipitation (RIP) assay. Finally, the effect of 150Rik on cell proliferation through the miR-451/insulin-like growth factor 1 receptor (IGF1R)/mitogen-activated protein kinases (p38MAPK) pathway was detected by EdU, flow cytometry analysis, western blot. Results: We found that 150Rik, an evolutionarily conserved lncRNA, was significantly upregulated in renal tissue of db/db DN mice and in mesangial cells (MCs) cultured under a high glucose condition. Further, overexpression or knockdown of 150Rik was found to regulate cell proliferation in MCs. Moreover, 150Rik was found to interact with miR-451 in both a direct and argonaute-2 (Ago2)-dependent manner. Results also revealed that overexpression of 150Rik inhibited cell proliferation through the miR-451/IGF1R/p38MAPK pathway in MCs under the high glucose condition, while knockdown of 150Rik increased cell proliferation via the miR-451/IGF1R/p38MAPK pathway. Conclusion: Taken together, these results provide new insight into the association between 150Rik and the miR-451/IGF1R/p38MAPK signaling pathway during DN progression.
Beta Adrenergic Receptors Stimulation Attenuates Phosphorylation of NF-κB and IκBα in Hyperglycemic Endothelial Cells
Authors: Safi Sher Zaman  , Shah Humaira , Qvist Rajes , Bindal Priyadarshni , Mansor Marzida , Yan Gracie Ong Siok , Ismail Ikram Shah Bin
Published: November 2018

Background/Aims: NF-κB induces transcription of a number of genes, associated with inflammation and apoptosis. In this study, we have investigated the effect of β-adrenergic receptor stimulation on NF-κB and IκBα in HUVECs. Methods: Human umbilical vein endothelial cells (HUVECs) were cultured in high and low glucose concentrations. All HUVECs were treated with different concentrations of isoproterenol and propranolol for different time periods. The analytical procedures consisted of Western Blot, ELISA, DCFH-DA and TUNEL assays. Results: Isoproterenol (agonist of a beta-adrenergic receptor) significantly reduced phosphorylation at Ser-536 of NF-κB; and Ser-32 and Ser-36 of IκBα in hyperglycemic HUVECs. Isoproterenol also significantly reduced apoptosis and ROS generation. No effect of IκBα was observed on Tyr-42 phosphorylation. The effect of isoproterenol was reversed by the antagonist propranolol. We also checked if NF-κB inhibitor MG132 causes any change at the level of apoptosis. However, we observed an almost similar effect. Conclusion: Given data demonstrates that beta-adrenergic receptors stimulation has a protective effect on HUVECs that might be occuring via NF-κβ and IκBα pathway.
Characterization of the Transcriptome of Hair Cell Regeneration in the Neonatal Mouse Utricle
Authors: Han Jinghong , Wu Hanwei , Hu Hongyi , Yang Weiqiang , Dong Hongsong , Liu Yuchen  , Nie Guohui
Published: November 2018

Background/Aims: Hearing and balance deficits are mainly caused by loss of sensory inner ear hair cells. The key signals that control hair cell regeneration are of great interest. However, the molecular events by which the cellular signals mediate hair cell regeneration in the mouse utricle are largely unknown. Methods: In the present study, we investigated gene expression changes and related molecular pathways using RNA-seq and qRT-PCR in the newborn mouse utricle in response to neomycin-induced damage. Results: There were 302 and 624 genes that were found to be up-regulated and down-regulated in neomycin-treated samples. GO and KEGG pathway analyses of these genes revealed many deregulated cellular components, molecular functions, biological processes and signaling pathways that may be related to hair cell development. More importantly, the differentially expressed genes included 9 transcription factors from the zf-C2H2 family, and eight of them were consistently down-regulated during hair cell damage and subsequent regeneration. Conclusion: Our results provide a valuable source for future studies and highlighted some promising genes, pathways or processes that may be useful for therapeutic applications.
Different PDGF Receptor Dimers Drive Distinct Migration Modes of the Mouse Skin Fibroblast
Authors: Yamada Kohta , Hamashima Takeru , Ishii Yoko , Yamamoto Seiji  , Okuno Noriko , Yoshida Naofumi , Yamada Moe , Huang Ting Ting , Shioda Norifumi , Tomihara Kei , Fujimori Toshihiko , Mori Hisashi , Fukunaga Kohji , Noguchi Makoto , Sasahara Masakiyo
Published: November 2018

Background/Aims: The migration of mesenchymal cells is a fundamental cellular process that has been implicated in many pathophysiological conditions and is induced by chemoattractants such as platelet-derived growth factors (PDGFs). However, the regulatory mechanisms shaping this migration remain to be elucidated. Methods: Here, we prepared mouse skin fibroblasts inactivated for different PDGF receptor genes and systematically measured their chemotactic responses within a gradient of different chemoattractants. Results: We found that PDGFRαβ and PDGFRββ dimers were strong inducers of random and directionally-persistent migration, respectively, that was sustained for up to 24 h. MAPK and PI3K were necessary to mediate random and directional migration, respectively. Directional migration was accompanied by abundant ventral stress fiber formation and consistent cell shape with less frequent formation of branch-like processes. Conclusion: This is the first systematic study that characterized the chemotaxis mediated by three-different types of PDGFR dimers in mesenchymal cell migration. Our data demonstrate that PDGFR dimer formation is the critical step to determine the specific mode of fibroblast chemotaxis, while the accompanying cytoskeletal remodeling might contribute to migration persistence.
The Serum microRNA Profile of Intrahepatic Cholestasis of Pregnancy: Identification of Novel Noninvasive Biomarkers
Authors: Zou Ping , Luo Liang , Zhao Chun , Chen Zhong , Dong Ruirui , Li Na , Wang Yao , Wang Jing , Wang Tiejun , Chen Minjian , Zhang Ting , Chen Daozhen
Published: November 2018

Background/Aims: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disease that significantly increases the risk of fetal complications. Here, we measured serum miRNA levels in ICP patients to identify candidate biomarkers for ICP. Methods: We used the Agilent miRNA array followed by reverse transcription-polymerase chain reaction assays to identify and validate the serum miRNA profiles of 40 pregnant women with ICP and 40 healthy pregnant controls. We used bioinformatics to identify metabolic processes related to differentially expressed miRNAs. Results: The expression levels of three miRNAs (miR-371a- 5p, miR-6865-5p, and miR-1182) were significantly increased in ICP patients compared to controls; the areas under the receiver operating characteristic (ROC) curves (AUCs) were 0.771, 0.811, and 0.798, respectively. Multiple logistic regression analysis showed that a combination of the levels of the three miRNAs afforded a greater AUC (0.845), thus more reliably diagnosing ICP. The levels of all three miRNAs were positively associated with that of total bile acids. Furthermore, bioinformatics analysis indicated that the three miRNAs principally affected lipid phosphorylation, apoptosis, and the MAPK signaling pathway. Conclusion: This preliminary work improves our understanding of serum miRNA changes in pregnant women with ICP. The three miRNAs may serve as novel noninvasive biomarkers of ICP.
Syntaxin 8 and the Endoplasmic Reticulum Processing of ΔF508-CFTR
Authors: Sabirzhanova Inna , Boinot Clément , Guggino William B. , Cebotaru Liudmila
Published: November 2018

Background/Aims: Cystic fibrosis (CF) is a lethal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR). ΔF508, the most common mutation, is a misfolded protein that is retained in the endoplasmic reticulum and degraded, precluding delivery to the cell surface [1]. Methods: Here we use a combination of western blotting, immunoprecipitation, and short circuit current techniques combined with confocal microscopy to address whether the SNARE attachment protein, STX8 plays a role in ΔF508’s processing and movement out of the ER. Results: Although the SNARE protein STX8 is thought to be functionally related and primarily localized to early endosomes, we show that silencing of STX8, particularly in the presence of the Vertex corrector molecule C18, rescues ΔF508-CFTR, allowing it to reach the cell surface and increasing CFTR-dependent chloride currents by approximately 2.5-fold over control values. STX8 silencing reduced the binding of quality control protein, Hsp 27, a protein that targets ΔF508-CFTR for sumoylation and subsequent degradation, to ΔF508-CFTR. STX8 silencing increased the levels of Hsp 60 a protein involving in early events in protein folding. Conclusion: STX8 knockdown creates an environment favorable for mature ΔF508 to reach the cell surface. The data also suggest that when present at normal levels, STX8 functions as part of the cell’s quality control mechanism.
Relationship between Aortic Arch Calcification, Detected by Chest X-Ray, and Renal Resistive Index in Patients with Hypertension
Authors: Adar Adem , Onalan Orhan , Keles Hakan , Cakan Fahri , Kokturk Ugur
Published: November 2018

Objective: Aortic arch calcification (AAC) is a surrogate marker for arterial stiffness and hypertension-related vascular damage. Renal resistive index (RRI), a renal Doppler ultrasonography parameter, is used to assess renal hemodynamics. In this study, we aimed to evaluate the relationship between RRI and AAC in patients with hypertension. Methods: Patients with hypertension underwent a chest X-ray and re nal Doppler ultrasonography. They were divided into two groups according to RRI (group 1: RRI ≥0.70; group 2: RRI < 0.70). Two examiners, blinded to the findings of RRI, reviewed the AAC in these patients. The kappa value was detected to be 0.781 and a p value < 0.001 was considered significant. Results: The study included 289 hypertensive patients (mean age 63.87 ± 11.38 years). In 53.6% (n = 155) of the study subjects, RRI was observed to be ≥0.70. Patients with RRI ≥70 were older and had more prevalent AAC as well as left ventricular hypertrophy. A multiple linear regression analysis was carried out to test whether presence of AAC significantly predicted RRI. The results of the regression analysis indicated that presence of AAC significantly predicted RRI (β = 0.053; p < 0.001). Conclusions: A strong and independent relationship was found between AAC on chest X-ray and RRI in patients with hypertension.
Clinicopathological Profiling of Lung Carcinoids with a Ki67 Index > 20%
Authors: Kasajima Atsuko , Konukiewitz Björn , Oka Naomi , Suzuki Hiroyoshi , Sakurada Akira , Okada Yoshinori , Kameya Toru , Ishikawa Yuichi , Sasano Hironobu , Weichert Wilko , Klöppel Günter
Published: November 2018

The clinicopathological features of lung neuroendocrine neoplasms (NEN) with a high proliferative index at the border area between atypical carcinoid and neuroendocrine carcinoma have not been investigated so far. The aim of this study was, therefore, to search for lung NENs which are well differentiated but show Ki67 values that overlap with those of poorly differentiated (PD)-NENs. Resected lung NENs from 244 Japanese patients were reviewed, and Ki67 indices were assessed in all tumors. The data were then correlated to clinicopathological parameters and patient outcome. Among 59 (24%) well-differentiated (WD)-NENs and 185 (76%) lung PD-NENs, 7 were defined as WD-NENs with Ki67 indices > 20%. The Ki67 indices of these tumors (mean 29%, range 24–36) were significantly lower than those of PD-NENs (mean 74%, range 34–99). All WD-NENs with Ki67 > 20% lacked abnormal p53 and loss of retinoblastoma 1 (Rb1) expression. In contrast, many PD-NENs expressed p53 (48%) and showed loss of Rb1 (86%). The 2- and 5-year disease-free survival rates in WD-NEN patients with Ki67 > 20% were lower than those of WD-NEN patients with Ki67 ≤20% (p < 0.01 for disease-free and overall survival). No statistical differences were detected between outcome of WD-NEN patients with Ki67 > 20% and those of PD-NEN. It is concluded that WD-NEN patients with Ki67 > 20% share the morphological and immunohistochemical features of WD-NEN patients with Ki67 ≤20%, but they have a worse prognosis, suggesting that this tumor group requires particular attention in future classifications and probably new therapeutic regimes.
РОЛЬ МЕДИЧНОЇ СЕСТРИ В ПРОФІЛАКТИЦІ УСКЛАДНЕНЬ ІШЕМІЧНОГО ІНСУЛЬТУ
Authors: Maiboroda O. V. , Sydorenko O. L.
Published: November 2018

У статті висвітлено роль медичної сестри у наданні допомоги хворим, які перенесли інсульт. Розглянуто основні моменти, на які необхідно звертати увагу при наданні допомоги для профілактики ускладнень мозкового інсульту.
ОСОБЛИВОСТІ МЕДИЧНОЇ ЕТИКИ ТА ДЕОНТОЛОГІЇ
Authors: Popovych Y. M.
Published: November 2018

У статті наведено особливості медичної етики і деонтології, а також принципи,які необхідно знати і дотримуватися медичним сестрам.
ПРОБЛЕМА ШКІДЛИВИХ ЗВИЧОК У ПІДЛІТКІВ
Authors: Zarudna O. I. , Zarudna D. O. , Abukhazhar O. P. , Karanevich M. I. , Lehka L. L.
Published: November 2018

У статті наведено дані анкетування підлітків щодо поширеності шкідливих звичок у їхньому середовищі, ставлення до шкідливих звичок школярів та їхнього оточення. Проведено аналіз отриманих результатів.
МОДЕЛЬ РОЗВИТКУ ІНФОРМАЦІЙНО-АНАЛІТИЧНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ МЕДИЧНИХ СЕСТЕР
Authors: Varava O. B.
Published: November 2018

У статті спроектовано модель розвитку інформаційно-аналітичної компетентності майбутніх медичних сестер в освітньому середовищі медичних коледжів; обґрунтовано взаємозв’язок і зміст її структурних блоків; сформульовано педагогічні умови її успішної реалізації.
Porfiria aguda intermitente com complicações decorrentes do diagnóstico tardio em paciente pediátrico
Authors: Cunha Gabriel Veloso , Gonçalves Suziane Soares , Silva Luana Cicília Sousa da , Fontes Tânia Maria De Souza , Silva Luciano Máximo da
Published: November 2018

A porfiria é uma doença rara, decorrente da deficiência enzimática associada à biossíntese do grupamento heme. O objetivo deste relato é descrever um caso de crise porfirêmica aguda intermitente em um paciente de 15 anos, que evoluiu rapidamente com tetraplegia e insuficiência renal crônica terminal, além de distúrbios neuropsiquiátricos. Representa uma entidade de difícil diagnóstico devido à inespecificidade dos achados clínicos. À admissão a creatinina era de 6,44 mg/dL e a uréia de 103 mg/dL. Déficit neurológico importante e insuficiência renal crônica são complicações raras, decorrentes do diagnóstico e tratamento tardio. É fundamental que o tratamento seja iniciado imediatamente após o diagnóstico, devido não somente à morbidade a curto-médio prazo, mas também aos possíveis efeitos deletérios permanentes.
Evolução da neurociência comportamental nos últimos 50 anos. Foco no sistema de defesa e na neurotransmissão
Authors: Graeff Frederico Guilherme
Published: November 2018

A evolução da Neurociência Comportamental nos últimos 50 anos é apresentada em função das pesquisas desenvolvidas pelo autor e colaboradores na área de Neuropsicofarmacologia. A principal linha de investigação relatada aborda o papel da serotonina na regulação das repostas de defesa, que estão relacionadas com as emoções ansiedade, medo e pânico, bem como com as respectivas patologias: transtorno de ansiedade generalizada, fobias e pânico. As estruturas cerebrais críticas para a ansiedade – amígdala, hipocampo e ínsula – estão localizadas no cérebro anterior, enquanto que as relacionadas com o medo e o pânico – hipotálamo e matéria cinzenta periaquedutal (MCP) – situam-se no diencéfalo e no tronco cerebral. Dá-se ênfase ao papel da MCP nas reações a ameaças proximais – imobilidade , fuga e luta – que estão relacionadas com ataques de pânico. São relatados resultados obtidos em modelos animais de pânico e em experimentação com seres humanos, incluindo testes de ansiedade experimental e neuroimagem morfométrica e funcional, cujas implicações para o conhecimento da fisiopatologia do transtorno de pânico e seu tratamento farmacológico são discutidas.
Advanced cancer
Authors: Vettori Josiane Cheli , Santos Andre Filipe Junqueira , Peria Fernanda Maris
Published: November 2018

Background: Cancer patients usually require palliative care. One of the reasons for this is malnutrition, which is common in these patients, affecting their prognosis and quality of life. Data on nutritional care in palliative care are still scarce. Objective: To characterize the diagnosis and nutritional care in palliative care cancer patients hospitalized in a public health setting. Methods: Descriptive retrospective cohort study on clinical, laboratory, and nutritional data obtained from medical records of cancer patients in palliative care. Results: A total of 128 admissions of cancer patients in palliative care were analyzed. Main primary cancer sites were in digestive, urologic and pulmonary systems. Mean age was 64.3±16.6 years. Patients were clinically and nutritionally compromised – mean performance status of 17.77±7.15, hemoglobin 9.6±2.37U/dL, albumin 2.64±0.64g/dL, C-reactive protein 125.37±68.37ml/L, and 60.8% of malnutrition (mean BMI of 20.19±5.57kg/m2). Oral route was the main route of administration (62.5%) and analysis of agreement revealed nutritional provision in excess of estimated daily requirements. No association was found between fasting condition, hospitalization outcome (death) and nutritional diagnosis (p=0.51). Conclusions: These cancer patients received palliative care just at the end stage of life, when most of them were malnourished, symptomatic, without specific oncologic treatment, and with a poor performance status. There was a preference for oral nutritional therapy, however, energy and protein supply were higher than the estimated nutritional requirements. The realization of fasting during hospitalization in the moments before death was not associated with the patient’s outcome.
Artrite Reumatoide de apresentação incomum
Authors: Dumbra Gabriel Antonio Cabriott , Conte Mariana Storino , Sestini Giulia , Casaroti Karoline Jacob , Teixeira Ana Laura Arroyo , Roma Daneila Vichiato Polizelli
Published: November 2018

A artrite reumatoide (AR) é uma doença de natureza autoimune, inflamatória, sistêmica e crônica, cuja característica clínica principal é a inflamação das articulações. Na sua apresentação habitual, o acometimento visceral ocorre após a instalação do quadro articular. O envolvimento pulmonar pode aparecer como derrame pleural, sendo este um evento incomum quando se apresenta como primeira manifestação da doença. Neste relato de caso, apresentamos um paciente do sexo masculino, de 52 anos diagnosticado posteriormente com Artrite Reumatoide, cuja manifestacão inicial foi o derrame pleural, demonstrando um desafio diagnóstico.
Carcinomas escamosos com miíase, uma nova tendência?
Authors: Rodrigues Felipe Tavares , Cardozo Marcos Roberto Pereira , Silva Larissa Raquel Klemig e , Aguiar Valéria Magalhães , Lessa Claudia Soares
Published: November 2018

Importância do problema: Este artigo se propõe a descrever dois casos de miíase em feridas neoplásicas de carcinomas escamosos, uma associação rara que vem se tornando comum. Comentários: Esta associação deve-se as altas prevalências de HPV, baixas condições socioeconômicas e de higiene, além do manejo inadequado de feridas e do descaso dos homens para com sua saúde, os principais afetados quando o assunto é câncer orofaríngeo e de pênis
Poliangiite microscópica com síndrome pulmão-rim
Authors: Rocha Francisco de Assis Pimentel , Farias Luis Arthur Brasil Gadelha , Jovino Ana Rívia Silva , Teixeira André Costa , Vieira Walber Pinto
Published: November 2018

A poliangiite microscópica (PAM) é uma vasculite necrosante sistêmica pauci-imune associada ao anticorpo anticitoplasma de neutrófilos (ANCA) com preferência de pequenos vasos. Relato do caso: Relatamos o caso de uma paciente do sexo feminino, 54 anos, que apresentou quadro de poliartrite migratória em punhos, joelhos e tornozelos associada à rigidez matinal progressiva, com histórico de “rash” malar, fotossensibilidade e alopecia. Progrediu ao longo do ano de 2017 com deterioração da função renal e hemorragia pulmonar, necessitando de cuidados intensivos. A biópsia renal sugeriu padrão compatível com glomerulonefrite pauci-imune e o diagnóstico de poliangiite microscópica foi aventado. Realizou pulsoterapia com metilprednisolona e ciclofosfamida, além de plasmaférese, recebendo alta após estabilização do quadro clínico. Importância do problema: O presente caso ilustra uma complicação incomum e de elevada morbimortalidade da PAM. A negatividade do ANCA dificultou o diagnóstico, sendo necessária a realização de biópsia renal com confirmação diagnóstica. A síndrome pulmão-rim apresenta evolução potencialmente fatal se não instituído precocemente o tratamento.
Do Out‐of‐Hospital Cardiac Arrest Patients Have Increased Chances of Survival When Transported to a Cardiac Resuscitation Center?
Authors: Lipe Demis , Giwa Al , Caputo Nicholas D. , Gupta Nachiketa , Addison Joseph , Cournoyer Alexis
Published: November 2018

Background

Patients suffering from an out‐of‐hospital cardiac arrest are often transported to the closest hospital. Although it has been suggested that these patients be transported to cardiac resuscitation centers, few jurisdictions have acted on this recommendation. To better evaluate the evidence on this subject, a systematic review and meta‐analysis of the currently available literature evaluating the association between the destination hospital's capability (cardiac resuscitation center or not) and resuscitation outcomes for adult patients suffering from an out‐of‐hospital cardiac arrest was performed.

Methods and Results

PubMed,
EMBASE
, and the Cochrane Library databases were first searched using a specifically designed search strategy. Both original randomized controlled trials and observational studies were considered for inclusion. Cardiac resuscitation centers were defined as having on‐site percutaneous coronary intervention and targeted temperature management capability at all times. The primary outcome measure was survival. Twelve nonrandomized observational studies were retained in this review. A total of 61 240 patients were included in the 10 studies that could be included in the meta‐analysis regarding the survival outcome. Being transported to a cardiac resuscitation center was associated with an increase in survival (odds ratio=1.95 [95% confidence interval 1.47‐2.59],
P
<0.001).

Conclusions

Adult patients suffering from an out‐of‐hospital cardiac arrest transported to cardiac resuscitation centers have better outcomes than their counterparts. When possible, it is reasonable to transport these patients directly to cardiac resuscitation centers (class
II
a, level of evidence B, nonrandomized).

Clinical Trial Registration

URL
:
www.crd.york.ac.uk/PROSPERO/
. Unique identifier:
CRD
42018086608.
Biermannia longicheila (Orchidaceae, Aeridinae), a new species from southern Vietnam
Authors: AVERYANOV LEONID V. , NURALIEV MAXIM S. , KUZNETSOV ANDREY N. , KUZNETSOVA SVETLANA P.
Published: November 2018

Biermannia King & Pantling (1898a: 591) comprises about ten species distributed from northeastern India and southern China through the Indochinese and Malay Peninsulas to Sumatra, Java and Borneo (Comber 1990, 2001, Seidenfaden & Wood 1992, Pearce & Cribb 2002, Chen & Wood 2009, Chase et al. 2015). All species of this genus are miniature, canopy epiphytes with small, unattractive fugacious flowers lasting only few hours in the morning. As a result, representatives of this genus are easily overlooked in botanical surveys, poorly represented in herbaria and remain infrequently inventoried in local floras throughout its range. One more new species that differs strikingly from all hitherto known species of this genus was recently discovered in southern Vietnam. Here we describe and illustrate this unusual plant.
Linaria argillicola (Plantaginaceae), a new species of L. sect. Supinae from the southern Iberian Peninsula
Authors: JUAN ANA , BLANCA GABRIEL , CUETO MIGUEL , FUENTES JULIÁN , SÁEZ LLORENÇ
Published: November 2018

A new species of the genus Linaria is described, illustrated and compared with its morphologically closest relatives from L. sect. Supinae: L. accitensis, L. aeruginea, L. tristis and L. badalii. A principal component analysis (PCA), correspondence analysis (CA), and linear discriminant analysis (LDA) were carried out for morphological differentiation. The species is characterized by long abaxial sepals, corolla mostly yellow or rarely reddish with wide tube, wide winged seeds with a tuberculate seminal disc, and a non-continuous fruiting inflorescence. Linaria argillicola is an edapho-endemic species, growing on the marly gypsiferous deposits from the Guadiana Menor river basin, on the border of Granada and Jaén provinces (Andalusia, Spain).
New narrowly distributed species of Myrcia s.l. (Gomidesia clade, Myrtaceae) from the Atlantic Forest of southeastern Brazil
Authors: AMORIM BRUNO S. , ALVES MARCCUS
Published: November 2018

Two new species of Myrcia s.l. from the Atlantic Forest of southeastern Brazil are here described and illustrated. Myrcia longisepala and M. rogersiana share morphological features which place them in the Gomidesia clade. The species are recorded for lowland and submontane forests in the Atlantic Forest. Myrcia longisepala is morphologically related to M. congestiflora, but differs by its smaller leaves, fewer secondary leaf veins, smaller petioles and fruits. Myrcia rogersiana is morphologically related to M. springiana, but differs by its reduced inflorescence main axis and flowers clustered at the apex of the inflorescence. Distribution maps and conservation assessments based on IUCN criteria are also given.
New and Newly Record Orchids of Nervilia (Nervilieae, Epidendroideae, Orchidaceae) in China
Authors: TANG FENG-XIA , LI JIAN-WU , PAN BO , WU XUN-FENG , LUO YONG , LIU QIANG
Published: November 2018

Nervilia Commerson ex Gaudichaud (1829: 42) is characterized by having prominent fan-shaped venation of leaves and developing flowers and leaves at different times and all above ground parts died back at the end of the growing season (Pridgeon et al. 2005). This genus comprised approximately 71 species, distributed from tropical, subtropical and warm temperate regions of Africa, Asia, Australia, and the Southwest Pacific islands (Govaert et al. 2017). The characteristic of ephemeral pattern of emergence tends to make plants overlooked in the field and under-represented in herbaria, and the temporal separation of the flowering and leafing phases makes complete or correctly matched collections rare (Seidenfaden 1978), confounding taxonomic understanding of the genus as a whole (Chen and Gale 2009). The genus was divided into four sections (Linervia, Vinerlia, Nervilia and Kyimbilaea) by Schlechter (1911, 1915), but Pettersson (1990a, b) sunk sect. Kyimbilaea into the sect. Linervia. Although revision of some confused species or new species have been published in the last decade (Gale et al. 2008, 2010, 2013, Eum et al. 2011, Jalal et al. 2012, Hsu et al. 2012), a comprehensive infrageneric delimitation combined with descriptions of morphological characters and molecular phylogeny within Nervilia is still needed.
A taxonomic revision of the genus Buddleja (Buddlejeae, Scrophulariaceae) in Brazil
Authors: COELHO GUILHERME PERES , MIOTTO SILVIA TERESINHA SFOGGIA
Published: November 2018

In this work, we revise the taxonomy of Buddleja in Brazil. This genus has 16 native and two introduced cultivated and adventitious species in the country. We present here descriptions, distribution and habitat information, flowering and fruiting periods, taxonomic remarks, photographs and propose a conservation status for each species.
New insights in the taxonomy of Trichobranchidae (Polychaeta) with description of a new Terebellides species from Australia
Authors: SCHÜLLER MYRIAM , HUTCHINGS PAT A.
Published: November 2018

During taxonomic studies on the Trichobranchidae housed at the Australian Museum, Sydney morphological characters of specimens were found to serve taxonomists on four taxonomic levels – family, genus, species and specimen level. The number of neuropodial uncini per torus and abdominal segments, long considered holding information for species determination, proved to be highly variable within species. Characters found to be consistent within species were e.g., the position of nephridial papillae, shape of branchiae and chaetae, and the development of anterior segments and lateral lappets. Also, staining in methyl green resulted in a clear pattern without intraspecific variability in most cases and is since considered a helpful tool for identification of Trichobranchidae. In this study an overview of morphological characters of Trichobranchidae and their information for taxonomy is given based on the trichobranchid collection of the Australian Museum. Additionally, description of a new species Terebellides jitu sp. nov., formerly treated as a variation of Terebellides narribri, is given. The description of T. narribri is revised.
A review of the taxa of solitary entoprocts (Loxosomatidae)
Authors: NIELSEN CLAUS
Published: November 2018

All taxa of solitary entoprocts (Loxosomatidae) are listed, along with information concerning the original description and also the type material for species where the depositories are mentioned in the descriptions or where type material has been found in various museums. The species belonging to Loxosoma (with 25 described species) are illustrated. It is recommended that the genus Loxosomella (with 118 described species) should be used in its wide sense to include Loxocorone, Loxomitra and Loxomespilon as subgenera. This move will make it possible to refer species to the correct genus even when the diagnostic details of the attachment organ are undescribed.
Mr. Darwin’s mysterious spider: on the type species of the genus Leucauge White, 1841 (Tetragnathidae, Araneae)
Authors: DIMITROV DIMITAR , HORMIGA GUSTAVO
Published: November 2018

For more than a century and a half the identity of Linyphia (Leucauge) argyrobapta White, 1841, the type species of the spider genus Leucauge, has been a mystery and an obstacle for revisionary work on this orb weaving genus. The only known specimen of argyrobapta, the type, was collected by Charles Darwin in Rio de Janeiro during the voyage of the H.M.S. Beagle and was lost after White’s description was published. We designate a neotype for Linyphia argyrobapta (White, 1841) based on specimens collected in the type locality. The common and widespread American species Leucauge venusta (Walckenaer, 1841) is a senior synonym of L. argyrobapta.
A molecular phylogenetic analysis of genus Anevrina (Diptera: Phoridae), with the description of a new species and updated world key
Authors: SMITH PAUL T. , BROWN BRIAN V.
Published: November 2018

Here we report on the first molecular phylogenetic study of the phorid genus Anevrina using a combination of nuclear (28S) and mitochondrial (12S, ND1 and CO1) genes for a total of 2220bp. Both maximum parsimony and Bayesian analyses recovered Anevrina as a monophyletic lineage within a broad sampling of phorid taxa that included 13 genera from 4 subfamilies. The higher-level relationships of phorid taxa based on the molecular tree were (Sciadocerinae + ((Hypocerinae + Phorinae) + Metopininae))). Relationships of species within Anevrina were also fully resolved with strong branch support in the form of posterior probabilities, bootstrap values, and decay indices. Two major clades were identified within Anevrina: ((A. luggeri + A. macateei) + (A. curvinervis + A. unispinosa)), which was joined as a sister group to ((A. variabilis + A. thoracica) + (A. olympiae + A. urbana)). A new and first Neotropical species, A. neotropica, from Costa Rica is described, illustrated, and included in an updated world key. Anevrina setigera (Loew, 1874) is synonymized with A. urbana (Meigen, 1830), new synonymy.
Parameristomerinx copelandi—a new genus and species of Afrotropical Pachygastrinae and a new generic synonym of Dolichodema Kertész (Diptera: Stratiomyidae)
Authors: WOODLEY NORMAN E.
Published: November 2018

A new genus and species, Parameristomerinx copelandi gen. et sp. n. (Diptera: Stratiomyidae: Pachygastrinae) is described from material from Kenya. This genus is similar to the Afrotropical genera Meristomerinx Enderlein, 1914 and Meristomeringina James, 1952. A new generic synonym is also proposed, Nemodema Lindner, 1958 = Dolichodema Kertész, 1916, syn. n. A key is included for the six genera related to Meristomerinx.
Ancinus jarocho (Isopoda: Sphaeromatidea: Ancinidae), a new species from the central Gulf of Mexico, Mexico
Authors: ROCHA–RAMÍREZ ARTURO , CHÁVEZ–LÓPEZ RAFAEL , PELÁEZ–RODRÍGUEZ EDGAR
Published: November 2018

Ancinus jarocho n. sp. described from mesolittoral zone of sandy beaches in Veracruz State, Mexico, is the eighth species of the genus and the second record for the Gulf of Mexico coast. The new species is characterized by an antennular flagellum of 11–16 articles, single aesthetasc in 9 distal flagellar articles, uropodal endopod styliform, lightly arched and shortest than pleotelson, male pleopod 5 exopod with the distomesial margin serrated, with minutes spines. Ancinus jarocho n. sp. is morphologically similar to A. granulatus, which has a truncate pleotelson apex, densely granulated body surface and eyes on elevated swellings.
New genera, species and host plant records of Nearctic and Neotropical Tephritidae (Diptera)
Authors: NORRBOM ALLEN L. , SUTTON BRUCE D. , STECK GARY J. , MONZÓN JOSÉ
Published: November 2018

Three new genera and five new species of Tephritidae (Diptera) are described from the Nearctic and Neotropical Regions. The new genera are: Agallamyia Norrbom (type species: A. pendula Norrbom, n. sp.), Neosphaeniscus Norrbom (type species: Euribia m-nigrum Hendel), and Phacelochaeta Norrbom (type species: Procecidochares quinquefasciata Hendel). The new species include: Acidogona stecki Norrbom (Guatemala, Mexico: Chiapas), Agallamyia pendula Norrbom (Guatemala), Phacelochaeta obliqua Norrbom (Ecuador), Procecidochares suttoni Norrbom (Guatemala), Stenopa mexicana Norrbom (Mexico). Five new generic synonyms are proposed: Cecidocharella Hendel, 1936 =4 · Zootaxa 2398 © 2010 Magnolia PressDracontomyia Becker, 1919; Gerrhoceras Hering, 1942 = Pyrgotoides Curran, 1934; Stoneola Hering, 1941 = Rhagoletis Loew, 1862; Strobelia Rondani, 1868 = Rachiptera Bigot, 1859; and Xenochaeta Snow, 1894 = Acidogona Loew, 1873. The following 41 new combinations are proposed: Acidogona dichromata (Snow), Dictyotrypeta crenulata (Wulp), D. incisa (Wulp), Dioxyna crockeri (Curran), Dracontomyia tucumana (Aczél), D. borrichia (Bush & Huettel), and D. elegans (Hendel), Homoeothrix aberrans (Schiner), Neosphaeniscus m-nigrum (Hendel) and N. flexuosus (Bigot), Paracantha trinotata (Foote), Phacelochaeta quinquefasciata (Hendel) and P. quinquevittata (Norrbom), Plaumannimyia ameghinoi (Brèthes), P. coelestina (Hering), P. delicatella (Blanchard), P. difficilis (Malloch), P. dolores (Hering), P. eugenia (Wulp), P. flava (Adams), P. hestiae (Hendel), P. imitatrix (Hering), P. miseta (Hering), P. plagiata (Blanchard), P. scutellata (Séguy), P. setulosa (Malloch), P. subaster (Malloch), P. suspecta (Malloch), P. thomsoni (Hendel), P. titschacki (Hering), and P. valdesiana (Gandolfo & Norrbom), Pyrgotoides paradoxus (Hering) and P. peruvianus (Korytkowski), Rachiptera alboguttata (Hendel), R. baccharidis (Rondani), R. bimaculata (Hendel), R. ferruginea (Hendel), R. lutulenta (Hendel), R. parallela (Hendel), and R. rubiginosa (Rondani), and Rhagoletis fuscobasalis (Hering). A lectotype is designated for R. fuscobasalis. New distribution and host plant records also are reported.
One new species of scorpion belonging to the genus Euscorpiops Vachon, 1980 from Yunan, China (Scorpiones: Euscorpiidae, Scorpiopinae)
Authors: SUN DONG , ZHU MING-SHENG
Published: November 2018

A new species of the genus Euscorpiops Vachon, 1980 is described, based on specimens collected from Menglian County, Yunnan Province, China. It is characterized by the following characters: (1) pectinal teeth number 7–7 in females and 8–8 in males; (2) cheliceral movable finger with 6–7 basal teeth on ventral edge; (3) chela ratio of length to width over 3.5 in females and over 4.1 in males; (4) a slight lobe on movable finger and corresponding notch on fixed finger in both males and females, with no marked sexual dimorphism; (5) patella with 19 external trichobothria (6eb, 2esb, 2em, 4est, 5et), and with 10 ventral trichobothria. With the species described in the present publication, the number of known species of Euscorpiops is raised to 17.
Parapiromis nom. nov., a new name for Piromis Fennah (Hemiptera: Fulgoromorpha: Ricaniidae), with descriptions of three new species
Authors: BU CUI-PING , LARIVIÈRE MARIE-CLAUDE , LIANG AI-PING
Published: November 2018

Parapiromis Bu, Larivière & Liang is created as a new name for Piromis Fennah (Hemiptera: Fulgoromorpha: Ricaniidae), which is preoccupied by Piromis Kinberg, 1869 (Annelida), and three new species of the genus are described and illustrated from the Pacific region: P. guadalcanalensis Bu & Liang sp. nov. (Solomon Islands), P. kiungaensis Bu & Liang sp. nov. (Papua New Guinea), P. santacruzensis Bu & Liang sp. nov. (Solomon Islands). P. translucida (Montrouzier) is redescribed and illustrated, including the external morphology of adult and the structure of the male and female genitalia. A key and a distribution map to the species of Parapiromis are provided.
Planeocoris, a new genus of Stenopodainae (Hemiptera: Heteroptera: Reduviidae) from Madagascar
Authors: CHŁOND DOMINIK
Published: November 2018

Planeocoris, a new genus and one new species P. redeii, are described based on a single specimen from Madagascar selected from undetermined materials of the Collection of the Muséum National d’Histoire Naturelle, Paris. The dorsal habitus as well as diagnostic characters of male genitalia are illustrated with 17 figures.
Family-group names proposed in the family Pseudococcidae (Hemiptera: Sternorrhyncha: Coccoidea)
Authors: WILLIAMS D. J. , GULLAN P. J.
Published: November 2018

Since Cockerell (1905) erected the family-group name Pseudococcini, the name has become widely used for all mealybugs. Lobdell (1930) raised the status of the group to family level as the Pseudococcidae, but it was not until Borchsenius (1949) and Ferris (1950) accepted the family level that the rank of Pseudococcidae became more widely accepted within the superfamily Coccoidea. Various tribes and subtribes have been introduced without any reliable classification of the family.
Four new species of the genus Brithura Edwards from China, with an updated key to world species (Diptera, Tipulidae)
Authors: LIU QIFEI , YANG DING
Published: November 2018

The following four new species of the genus Brithura Edwards from China are described: B. shii sp. nov., B. aureola sp. nov., B. flaviflagellum sp. nov., B. stigmosa sp. nov. An updated key to the world species of the genus Brithura is presented.
Revision of Metadorodocia Machatschke, 1957, a genus endemic to Madagascar (Coleoptera: Scarabaeidae: Rutelinae: Adoretini)
Authors: AKHMETOVA LILIA , MONTREUIL OLIVIER
Published: November 2018

The genus Metadorodocia, which is endemic to Madagascar, is revised. A lectotype is designated for its type species, Adoretus vittatus Waterhouse, 1878. A second species of this genus, Metadorodocia frolovi n. sp., is diagnosed from M. vittata and described. Illustrations for both species are provided and their distributions are clarified.
A new name in the genus Ocypus Leach, 1819 (Coleoptera: Staphylinidae, Staphylinini, Staphylinina)
Authors: SMETANA ALEŠ
Published: November 2018

When describing Ocypus (Pseudocypus) bicolor Smetana, 2008: 175 from China: Sichuan, I overlooked the fact that the name was a junior secondary homonym of Staphylinus helleni var. bicolor J. Müller, 1943: 105 (in Ocypus) from Caucasus. I therefore provide a replacement name Ocypus (Pseudocypus) bicoloris new name, for Ocypus (Pseudocypus) bicolor Smetana, 2008, nec Ocypus (Pseudocypus) bicolor (J. Müller, 1943).
A new dromaeosaurid (Dinosauria: Theropoda) from the Upper Cretaceous Wulansuhai Formation of Inner Mongolia, China
Authors: XU XING , CHOINIERE JONAH N. , PITTMAN MICHAEL , TAN QINGWEI , XIAO DONG , LI ZHIQUAN , TAN LIN , CLARK JAMES M. , NORELL MARK A. , HONE DAVID W. E. , SULLIVAN CORWIN
Published: November 2018

We describe a new dromaeosaurid theropod from the Upper Cretaceous Wulansuhai Formation of Bayan Mandahu, Inner Mongolia. The new taxon, Linheraptor exquisitus gen. et sp. nov., is based on an exceptionally well-preserved, nearly complete skeleton. This specimen represents the fifth dromaeosaurid taxon recovered from the Upper Cretaceous Djadokhta Formation and its laterally equivalent strata, which include the Wulansuhai Formation, and adds to the known diversity of Late Cretaceous dromaeosaurids. Linheraptor exquisitus closely resembles the recently reported Tsaagan mangas. Uniquely among dromaeosaurids, the two taxa share a large, anteriorly located maxillary fenestra and a contact between the jugal and the squamosal that excludes the postorbital from the infratemporal fenestra. These features suggest a sister-taxon relationship between L. exquisitus and T. mangas, which indicates the presence of a unique dromaeosaurid lineage in the Late Cretaceous of Asia. A number of cranial and dental features seen in L. exquisitus and T. mangas, and particularly some postcranial features of L. exquisitus, suggest that these two taxa are probably intermediate in systematic position between known basal and derived dromaeosaurids. The discovery of Linheraptor exquisitus is thus important for understanding the evolution of some salient features seen in the derived dromaeosaurids.
Systematics and ecology of the genus Dendrozetes (Acari: Oribatida: Peloppiidae) from arboreal habitats in Western North America
Authors: LINDO ZOE , CLAYTON MARILYN , BEHAN-PELLETIER VALERIE
Published: November 2018

We present the systematics and ecology of a new species of arboreal oribatid mite in the family Peloppiidae (Acari: Oribatida), Dendrozetes jordani n. sp., a dominant arthropod on branch tips and arboreal lichens associated with western hemlock (Tsuga heterophylla (Pinaceae)) and Pacific silver fir (Abies amabilis (Pinaceae)) in the coniferous temperate and montane forests of the Pacific Northwest of North America. Dendrozetes jordani represents the first record of the genus Dendrozetes in North America. The species is described on the basis of morphology of all active instars plus molecular sequence data for the mitochondrial cytochrome oxidase I (COI) gene. Dendrozetes jordani is compared with type specimens of D. caudatus Aoki from Japan, and a revised diagnosis of the genus Dendrozetes is given. Dendrozetes jordani has a stable, overlapping population structure through the year, and its association with trees in Pinaceae is an ecological characteristic shared with D. caudatus from Japan.