bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of an LC–MS/MS Assay and Toxicokinetic Characterization of Hexamethylenetetramine in Rats
Authors: Kim Woojin , Kim Eunbin , Lee Jaewoong , Song Chang Ho , Jung Woohyung , Shin Soyoung , Kim Kyu-Bong , Shin Beom Soo , Kim Tae Hwan
Published: April 2023

Hexamethylenetetramine, an aldehyde-releasing agent, is used as a preservative in various food, cosmetics, and medical treatments, such as a treatment for urinary tract infections. It has been reported to be allergenic on contact with the skin, with the additional possibility of causing toxicity once absorbed systemically. Despite its potential toxicity, there are no reports on the in vivo bioavailability of hexamethylenetetramine following oral or dermal administration. In this study, we developed a new simple and sensitive LC–MS/MS method for the determination of hexamethylenetetramine in plasma and applied this method to characterize the toxicokinetics. The developed assay had a sufficient specificity and sensitivity for toxicokinetic characterization, and its accuracy and precision were verified. Following iv injection, the plasma concentration of hexamethylenetetramine showed mono exponential decay, with an elimination half-life of about 1.3 h. Following oral administration, the Tmax reached an average of 0.47 h and bioavailability was estimated as 89.93%. After percutaneous administration, it reached Cmax on average at 2.9–3.6 h. Although the absorption rate was relatively slow, its average bioavailability was calculated as 77.19–78.91%. Overall, most of the orally and percutaneously administered hexamethylenetetramine was absorbed into systemic circulation. The derived results in this study are expected to be utilized as the scientific evidence for further toxicokinetic study and risk assessment.
Multilevel Comparison of Indian Naja Venoms and Their Cross-Reactivity with Indian Polyvalent Antivenoms
Authors: Deka Archana , Bhatia Siddharth , Santra Vishal , Bharti Omesh K. , Lalremsanga Hmar Tlawmte , Martin Gerard , Wüster Wolfgang , Owens John B. , Graham Stuart , Doley Robin , Malhotra Anita
Published: April 2023

Snake envenoming is caused by many biological species, rather than a single infectious agent, each with a multiplicity of toxins in their venom. Hence, developing effective treatments is challenging, especially in biodiverse and biogeographically complex countries such as India. The present study represents the first genus-wide proteomics analysis of venom composition across Naja species (N. naja, N. oxiana, and N. kaouthia) found in mainland India. Venom proteomes were consistent between individuals from the same localities in terms of the toxin families present, but not in the relative abundance of those in the venom. There appears to be more compositional variation among N. naja from different locations than among N. kaouthia. Immunoblotting and in vitro neutralization assays indicated cross-reactivity with Indian polyvalent antivenom, in which antibodies raised against N. naja are present. However, we observed ineffective neutralization of PLA2 activities of N. naja venoms from locations distant from the source of immunizing venoms. Antivenom immunoprofiling by antivenomics revealed differential antigenicity of venoms from N. kaouthia and N. oxiana, and poor reactivity towards 3FTxs and PLA2s. Moreover, there was considerable variation between antivenoms from different manufacturers. These data indicate that improvements to antivenom manufacturing in India are highly desirable.
Scattering in Algebraic Approach to Quantum Theory—Jordan Algebras
Authors: Schwarz Albert
Published: April 2023

Using the geometric approach, we formulate a quantum theory in terms of Jordan algebras. We analyze the notion of a (quasi)particle (=elementary excitation of translation-invariant stationary state) and the scattering of (quasi)particles in this framework.
Evolving Treatment Options for Metastatic Renal Cell Carcinoma (mRCC)
Authors: Yu Eun-mi , Mudireddy Mythri , Patel Ishan , Aragon-Ching Jeanny B.
Published: April 2023

Approximately a third of patients diagnosed with kidney cancer in the United States present with advanced disease and those who present with distant metastases historically had dismal 5-year relative survival. However, over the last several years, advancements have led to improved life expectancy and patient outcomes in those who develop advanced renal cell carcinoma. Metastatic clear cell renal cell carcinoma (mccRCC) treatment has rapidly evolved with multiple drug approvals since 2006. Moreover, multiple combination regimens including a vascular endothelial growth factor tyrosine kinase inhibitor (VEGF-TKI) plus immune checkpoint inhibitor (ICI) and the combination of ipilimumab plus nivolumab have supplanted first-line VEGF-TKI monotherapy. Thus, the insights we gained from prospective randomized controlled trials focusing on systemic therapy beyond first-line therapy in mRCC patients treated in the TKI monotherapy era quickly became less relevant with the adoption of contemporary first-line combination regimens. Herein, we will review contemporary first- and second-line therapies for mccRCC, as well as highly anticipated clinical trials looking into novel regimens beyond first-line therapy in patients who have received combination therapy.
Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo
Authors: Raj Sneha , Vishwakarma Preeti , Saxena Shikha , Kumar Varun , Khatri Ritika , Kumar Amit , Singh Mrityunjay , Mishra Surbhi , Asthana Shailendra , Ahmed Shubbir , Samal Sweety
Published: April 2023

Immunogens mimicking the native-like structure of surface-exposed viral antigens are considered promising vaccine candidates. Influenza viruses are important zoonotic respiratory viruses with high pandemic potential. Recombinant soluble hemagglutinin (HA) glycoprotein-based protein subunit vaccines against Influenza have been shown to induce protective efficacy when administered intramuscularly. Here, we have expressed a recombinant soluble trimeric HA protein in Expi 293F cells and purified the protein derived from the Inf A/Guangdong-Maonan/ SWL1536/2019 virus which was found to be highly virulent in the mouse. The trimeric HA protein was found to be in the oligomeric state, highly stable, and the efficacy study in the BALB/c mouse challenge model through intradermal immunization with the prime-boost regimen conferred complete protection against a high lethal dose of homologous and mouse-adapted InfA/PR8 virus challenge. Furthermore, the immunogen induced high hemagglutinin inhibition (HI) titers and showed cross-protection against other Inf A and Inf B subtypes. The results are promising and warrant trimeric HA as a suitable vaccine candidate.
Clinical Effects of Faecal Microbiota Transplantation as Adjunctive Therapy in Dogs with Chronic Enteropathies—A Retrospective Case Series of 41 Dogs
Authors: Toresson Linda , Spillmann Thomas , Pilla Rachel , Ludvigsson Ulrika , Hellgren Josefin , Olmedal Gunilla , Suchodolski Jan S.
Published: April 2023

Chronic enteropathies (CE) are common in dogs, but not all affected dogs respond to standard therapy. Successful responses to faecal microbial transplantation (FMT) in dogs with non-responsive CE have been reported in two case series. The objective of this retrospective study was to describe the clinical effects of FMT as an adjunctive therapy in a larger population of dogs with CE. Forty-one dogs aged 0.6–13.0 years (median 5.8) under treatment for CE at one referral animal hospital were included. Dogs were treated with 1–5 (median 3) FMTs as a rectal enema at a dose of 5–7 g/kg body weight. The canine inflammatory bowel disease activity index (CIBDAI) was compared at baseline versus after the last FMT. Stored faecal samples (n = 16) were analysed with the dysbiosis index. CIBDAI at baseline was 2–17 (median 6), which decreased to 1–9 (median 2; p < 0.0001) after FMT. Subsequently, 31/41 dogs responded to treatment, resulting in improved faecal quality and/or activity level in 24/41 and 24/41 dogs, respectively. The dysbiosis index at baseline was significantly lower for good responders versus poor responders (p = 0.043). Results suggest that FMT can be useful as an adjunctive therapy in dogs with poorly responsive CE.
Distribution of Silver (Ag) and Silver Nanoparticles (AgNPs) in Aquatic Environment
Authors: Mat Lazim Zainab , Salmiati Salmiati , Marpongahtun Marpongahtun , Arman Nor Zaiha , Mohd Haniffah Mohd Ridza , Azman Shamila , Yong Ee Ling , Salim Mohd Razman
Published: April 2023

Nanomaterials, classified as emerging pollutants that are toxic to the environment, are known to bioaccumulate across different trophic levels in the aquatic ecosystem. This study therefore investigates the distribution of silver and silver nanoparticles (AgNPs) in the aquatic environment of Skudai River, Johor, Malaysia. Water, sediment, plant, and fish samples were collected seasonally along four sites along Skudai River between May 2018 and April 2019. All samples were subjected to Ag analysis using an inductively coupled plasma mass spectrometer (ICP-MS). The analysis demonstrated that the concentration of Ag detected in water samples ranging from 0.001 to 0.505 mg/L was the lowest, whereas in the plants, 0.235 to 4.713 mg/kg of Ag was quantified. The upper sediments contained 0.036 to 28.115 mg/kg of Ag, whilst fish samples presented the highest accumulation of Ag, averaging between 9.144 and 53.784 mg/kg of Ag. Subsequently, the formation of silver nanoparticles was further proven by TEM-EDX analysis, where the detected size of AgNPs ranged from 20 nm to 35 nm. The overriding conclusion implied by bioaccumulation factor (BAF) and biota–sediment accumulation factor (BSAF) calculations suggested that Skudai River was indeed polluted by Ag and AgNPs. The values obtained stipulated that silver accumulation is occurring at an alarming rate and could therefore endanger fish consumers.
River Green Land and Its Influence on Urban Economy, Leisure Development, Ecological Protection, and the Well-Being of the Elderly
Authors: Du Xiao-Juan , Lin Hsiao-Hsien , Hsu I-Cheng , Ling Ying , Zhang Su-Fang , Li Qi-Yuan
Published: April 2023

The purpose of this study is to analyze whether the green space generated by river water engineering can promote urban development and the well-being of the elderly in high-risk environments. Firstly, quantitative research methods were used to analyze 750 valid questionnaires, and IBM SPSS Statistics 26.0 statistical software was used for data inspection. We continued to adopt the qualitative research method and collect the opinions of nine respondents according to the results of the questionnaire analysis. The data were then integrated, categorized, summarized, compared, and finally examined by multivariate analysis. The river green land has rich ecological and natural landscape resources and spacious leisure space, creating a comfortable leisure and living environment. This can increase job opportunities, promote community and economic development, and create safe leisure conditions. It can also improve people’s willingness for leisure, increase opportunities for interpersonal communication, and improve the quality of life and happiness of the elderly. If we should strengthen the soil structure of the river, pay attention to ecological conservation, and reduce exhaust gas and noise pollution to provide a more complete leisure space and enhance the contribution of river green space to rural areas and lives of the local elderly.
Using the Spatiotemporal Hot Spot Analysis and Multi-Annual Landslide Inventories to Analyze the Evolution and Characteristic of Rainfall-Induced Landslide at the Subwatershed Scale in Taiwan
Authors: Wu Chunhung
Published: April 2023

This study used rainfall and annual landslide data for the 2003–2017 period in Taiwan to determine the long-term evolution of landslides and conducted a spatiotemporal analysis of landslides at the subwatershed scale. The historically severe landslide induced by Typhoon Morakot in 2009 was mainly distributed in the central mountainous region and southern Taiwan. The Mann–Kendall trend test revealed that in 2003–2017, 13.2% of subwatersheds in Taiwan exhibited an upward trend of landslide evolution. Local outlier analysis results revealed that the landslide high–high cluster was concentrated in the central mountainous region and southern Taiwan. Moreover, the spatiotemporal analysis indicated 24.2% of subwatersheds in Taiwan in 2003–2017 as spatiotemporal landslide hot spots. The main patterns of spatiotemporal landslide hot spots in 2003–2017 were consecutive, intensifying, persistent, oscillating, and sporadic hot spots. The recovery rate in the first two years after the extreme rainfall-induced landslide event in Taiwan was 22.2%, and that in the third to eighth years was 31.6%. The recovery rate after extreme rainfall-induced landslides in Taiwan was higher than that after major earthquake-induced landslides in the world, and the new landslides were easily induced in the area of rivers and large landslide cases after Typhoon Morakot in 2009.
Solar Light-Induced Photocatalytic Degradation of Sulfamethoxazole by Cobalt Phosphide-Promoted Bismuth Vanadate
Authors: Ioannidi Alexandra A. , Zappa Joanne , Petala Athanasia , Souliotis Manolis , Mantzavinos Dionissios , Frontistis Zacharias
Published: April 2023

The pursuit of low-cost, high-efficiency co-catalysts that are free of noble metals has become an area of considerable interest in the field of photocatalysis over the past few years. In this work, a series of cobalt phosphide (CoP 0.125–1.00 wt.%)-promoted bismuth vanadate (BiVO4) photocatalysts was synthesized and physicochemical characterized by means of X-Ray diffraction, nitrogen isotherm absorption diffuse-reflectance spectroscopy, and high-resolution transmission electron microscopy. The efficiency of the as prepared photocatalytic materials was investigated for sulfamethoxazole (SMX) destruction in ultrapure water under simulated solar light irradiation. Results showed that the deposition of small amounts (0.50 wt.%) of CoP on BiVO4 enhances SMX degradation. Moreover, SMX removal increased by increasing 0.50 CoP/BiVO4 loading (up to 1 g/L) and decreasing SMX loading (1000–250 μg/L). Further tests were carried out in real and synthetic matrices, such as wastewater secondary effluent and bottled water, revealing the existence of hindering effects on SMX removal. The efficiency of 0.50 CoP/BiVO4 photocatalyst was further investigated in a pilot plant configuration where the examined system was able to remove >99% of 300 μg/L SMX in deionized water utilizing 80 kJ/L of solar irradiation.
A Framework for Assessment of Flood Conditions Using Hydrological and Hydrodynamic Modeling Approach
Authors: Kumar Anil , Khosa Rakesh , Gosian Ashwin Kumar
Published: April 2023

River flooding has been triggering significant damage to lives and infrastructure and is a major worry all around the globe. To lessen these losses, proper planning and management methods need to be deployed. The purpose of this research is to fill a knowledge gap on the effects of reservoirs operation of the Idukki and Idamalyar to Periyar River Basin massive flooding. The proposed methodology is implemented on the Periyar River Basin located in Kerala, India, where severe flooding occurred during monsoon season in the year 2018. In this study, modelling technique has been used in two-step: (1) development of 1D physically based, distributed-parameter model (Soil and Water Assessment Tool, SWAT) to compute the stream flow and estimate the stream discharge at different outlet points; and (2) hybrid model is developed by linking SWAT with a well-known 2D hydrodynamic model (International River Interface Cooperative, iRIC) to display flood scenarios and to identify the flood-prone areas. The ArcSWAT user interface employed in the ArcGIS software was utilized to delineate the river basin. The SWAT model was calibrated and validated on daily and monthly basis at two gauge discharge stations, i.e., Neeleeswaram and Kalady. The statistical coefficients result obtained from SWAT model was in good agreement with the measured values for calibration and validation. The hybrid model simulation results compared with observed flood depth and remote sensing data demonstrated good capability of the model. Agreeable performances of computed results were observed in both flow fields and flood propagations. The result was compared with 2018 flood to check model accuracy and found to be satisfactory. The proposed framework can be utilized as an effective tool for efficient planning and management of natural disasters, such as flash floods.
Effects of Climate Change on Navigability Indicators of the Lower Athabasca River, Canada
Authors: Peters Daniel L. , Dibike Yonas B. , Shudian Joseph , Monk Wendy A. , Baird Donald J.
Published: April 2023

The lower Athabasca River (Canada) has experienced notable declines in streamflow and increasing oil sands development since the 1970s. This study investigates the potential impacts of climate change on navigability using both observed historical and projected future flows derived via hydrological simulations driven by an ensemble of statistically downscaled general circulation model climate data. Our use of proposed indices that form the Aboriginal Navigation Index (ANI) and a new index based on percentage over threshold (POT) occurrences yielded novel insights into anticipated changes to the flow regime. Comparisons of near (2041–2070) and far (2071–2100) future periods with the historical baseline (1981–2010) yielded results that project significant reductions in the 500 m3 s−1 POT during the fall navigability period spanning weeks 34 to 43, as well as reductions in the integrated ANIFall. These results indicate that challenging navigational conditions may become more frequent in the second half of the 21st century, not only during this fall period but also earlier into the summer, due to a shift in the flow regime, with potentially severe impacts on the users of the river channels. Our assessment approach is transferable to other regional study areas and should be considered in water management and environmental flow frameworks.
Smooth Speed Control of Permanent Magnet Synchronous Machine Using Back Propagation Neural Network
Authors: Zhao Chenhao , Zuo Yuefei , Wang Huanzhi , Hou Qiankang , Lee Christopher H. T.
Published: April 2023

Torque ripple is one of the most critical problems in PMSM system. In this paper, a neural network (NN) torque compensator is combined with a conventional extended state observer (ESO)-based active disturbance rejection controller (ADRC) system to suppress the torque ripple at wide machine operation speed range by generating the optimal current reference. The ESO is able to estimate and reject the low-frequency component in the torque ripple, while the remaining disturbances can be learned and compensated by the neural network. Compared with commonly used schemes, the proposed method does not need to analyze the influence of various sources of the torque ripple, such as the cogging torque, non-sinusoidal back-EMF, parameter variations, and unmodeled disturbances. In addition, the simple structure of the neural network helps reduce the computation time and save computer memory. The effectiveness of the proposed neural network compensator with both the rotor position and mechanical angular velocity as inputs is verified in the experiment under different operation speeds.
A Method for Electric Tractor Molding Based on Terminal Sliding Mode Control Algorithm
Authors: Yin Shanshan , Mao Pengjun , Li Wenjun
Published: April 2023

Smart transformation and green development are the core research directions of electric vehicles. An electric tractor is powered by the vehicle battery. The motor converts electric energy into mechanical energy and drives the wheels through the drive train. Therefore, the electric tractor model is a modular mathematical model for the battery, motor, drive train, and drive wheel. A class of high-order terminal sliding mode control strategies is adopted to establish the relative rotational angles of drive wheels, driving angular speeds, and motor angular speeds as input, and driving angular speeds and motor angular speeds as output. This process ensures stable operating speed and good working quality under the operating conditions and achieves small-scale unattended driving. The output is a nonlinear system state equation. An n-order derivative continuous function is introduced to design the terminal sliding surface of the sliding mode. A control function to reduce chattering is also designed to ensure that the output function converges at the finite time and the existing sliding stage achieves zero steady-state error. Simulation results of the whole electric tractor model show that the speed remains stable under the condition of outside interference, and experiments verify the feasibility of the control strategy.
Periodontal pathogens and antibiotic resistance genes in individuals with chronic generalized periodontitis
Authors: Opravin A. S. , Galieva A. S. , Davidovich N. V. , Spiricheva E. P. , Polivanaya E. A. , Bazhukova T. A.
Published: April 2023

Relevance. Considering the role of personalized medicine in dental practice, the accumulation of knowledge about the genetic determinants of bacterial resistance and the use of antibacterial drugs, the learning of periodontal microbiota, sensitivity to antimicrobial drugs, the identification of key periodontal pathogens will allow predicting the development mechanisms of inflammatory periodontal diseases and monitoring and prescribing effective antibacterial therapy.Aim. The study aimed to determine the prevalence of pathogens and the occurrence of antibiotic resistance genes in individuals with chronic generalized periodontitis (CGP).Materials and methods. Clinical and laboratory examinations studied 163 subjects aged 18 to 45 years, of which there were 100 patients with inflammatory periodontal diseases and 63 subjects with intact periodontium. The study obtained periodontal pocket and gingival crevice swabs. The real-time PCR isolated marker bacteria and resistance genes to glycopeptide and β-lactam antibiotics.Results. The patients with chronic periodontitis demonstrated a periodontal pathogen detection rate of 96.4 %. Among the isolated periodontal pathogens, bacteria of the red complex were the most common: T. forsythia (81%; p < 0.001), T. denticola (63%; p = 0.054) and P. gingivalis (69%; p < 0.001). In healthy individuals with intact periodontium, P. gingivalis (12.7%), T. denticola (47.62%), and T. forsythia (36.51%) prevailed in the studied material, i.e., gingival fluid. The mean ratio of bone loss in relation to the root length (the Fuchs Index) was 0.83 ± 0.03 in patients with mild CGP and 0.71 ± 0.05 with moderate CGP. The β-lactam antibiotic resistance genes appeared to occur frequently (%). So, TEM and SHV genes were in 72% and 26%. The control group demonstrated the TEM gene in 41.27% (p < 0.001) and the SHV gene in 4.76% (p < 0.001).The group with CGP appeared to have resistance genetic markers: MecA to cephalosporins (15%) and OXA-51 to carbapenems (9%). The control group detected MecA (6.35%; p = 0.0948), while OXA-51 markers were absent (p = 0.014). Both groups did not show resistance genes to other antibiotic groups (AB).Conclusion. The "red complex" microorganisms T. forsythia, T. denticola and P. gingivalis, which were the most frequent during the progression of bone destruction, appeared to play the leading role in the onset and progression of inflammatory periodontal diseases.The oral microbiome can serve as a reservoir for the transfer of resistance genes: the study results indicate a high incidence rate (%) of β-lactam antibiotic resistance genes in the group of patients with chronic periodontitis. The group with chronic periodontitis revealed TEM and SHV genes in 72% and 26%, respectively. The group with intact periodontium also demonstrated a high occurrence rate of the TEM gene in 58.3 % of cases.
Evaluation of oroantral communication potential risk during maxillary teeth extraction in patients with different types of facial skeleton
Authors: Zhidkov R. A. , Tsitsiashvili A. M. , Vasiliev Ju. L. , Panin A. M. , Lezhnev D. A. , Gurevich K. G.
Published: April 2023

Relevance. Tooth extraction is the most common operation in oral surgery practice. For oroantral communication (OAC) treatment and prevention as one of the surgery complications, it is paramount to study the prevalence of anatomical risk factors for OAC in patients based on their facial sk eleton type.Materials and Methods. We analyzed 1629 cone-beam CT scans of patients aged 18 to 85 years of both sexes to determine the potential risk of OAC in patients with different types of the facial skeleton.Results. The overall assessment of OAC potential risk demonstrated a high risk in 29.7% of cases (4514 teeth) (p < 0.01). The high-risk group determined teeth most often in patients with a mesoprosopic type of facial skeleton – 31.2% of cases (2912 teeth), in euryprosopic – 29.46% (914 teeth), in leptoprosopic – 24.96% of cases, (688 teeth), (p < 0.01). The potential risk of the first and second molar OAC was the highest of all teeth in all facial skeleton types (p < 0.01).Conclusion. A potentially high OAC risk of about 30% can be related to the upper teeth, located in the maxillary sinus floor area in patients with any facial skeleton type, though the risk is higher in meso- and euryprosopic types (p < 0.01). Among all groups of teeth, the highest potential risk of OAC (up to 40%, p < 0.01) is in the maxillary 1st and 2nd molar region in any facial sk eleton type.
Taxons nouveaux dans le genre Arceuthobium M. Bieb. (Viscaceae, Santalales)
Authors: Fridlender Alain
Published: April 2023

Une nouvelle espèce de gui nain du genévrier est décrite en Provence : Arceuthobium gambyi Fridl. Ses tiges, fleurs et graines sont plus grandes que celles d’A. oxycedri (DC.) M. Bieb. Ses fleurs sont tri-ou tétramères, vs. dimères ou trimères chez A. oxycedri. Leur quantité d’ADN 2C diffère : 2C = 20 pg chez A. gambyi et 2C = 18,2 pg chez A. oxycedri. Endémique ibéro-provençal, A. gambyi parasite Juniperus phoenicea et rarement J. oxycedrus, tandis que A. oxycedri semble inconnu sur J. phoenicea. Deux taxons infra-spécifiques sont décrits en Espagne (A. gambyi var. fagcii Fridl.) et en Algérie (A. oxycedri var. shadii Fridl.).
NANOCERIA INFUSED CHITOSAN-PVA HYDROGELS TO TREAT BURN WOUNDS
Authors:   University of Georgia, Athens, GA, Tavares Lucas , Shim Minchan , Borole Ruchi Patil , Mohakar Vijay , Sorkin Anton , Reukov Vladimir
Published: April 2023

Burn wounds are highly dangerous injuries with significant mortality rates. They are painful and increase the risk of bacterial infection. Burn wounds could also harm adjacent tissues by releasing dangerous compounds. Thus, their treatment should work quickly and effectively. Hydrogels are used as burn wound dressings that provide a suitable environment for regeneration. They closely imitate the structure of the skin’s extracellular matrix and have high water uptake properties, providing a moist environment for faster healing. Chitosan-PVA based hydrogels demonstrated antibacterial and healing effects on wounds. Nanoparticles of cerium oxide called nanoceria were shown to reduce local oxidative stress by decomposing reactive oxygen species. The goal of this study is to learn the effects of nanoceria infused chitosan-PVA hydrogels on wound regeneration. We characterized hydrogels with various chitosan-PVA ratios, crosslinked with tetraethyl orthosilicate. These trials improved the procedure for making hydrogels capable of maintaining a moist environment for better wound healing. Further experiments demonstrated the biocompatibility and antibacterial properties of the hydrogels crosslinked with glutaraldehyde, where 3T3 fibroblasts seeded on the hydrogels were shown to be viable and zone of inhibition tests performed with E. coli demonstrated the antibacterial capacity of the hydrogels. Future studies will determine the antioxidant capacity and further bioactive properties of the nanoceria infused hydrogel. Once the small-scale procedure is well established the proposed methods could be implemented in clinical applications to aid in burn wound recovery.
Зміни ігрових показників гандболістів 13–14 років під впливом вправ координаційної спрямованості
Authors: Pomeschikova I. P , Bykova Helena
Published: April 2023

В статті наведені результати педагогічного експерименту, метою якого було підвищити ефективність ігрової діяльності гандболістів 13-14 років використовуючи спеціально-розроблену програму підготовки юнаків. У дослідженні приймали участь дві групи юнаків по 14 осіб в кожній, віком 13-14 років, що займались у групах ДЮСШ з гандболу. Експериментальна програма будувалась на виконанні акробатичних вправ та стрибкових вправах із застосуванням координаційної драбини, що були спрямовані на подразнення вестибулярного апарату та утримання рівноваги спортсменами та їх виконання поєднувалось із виконанням технічних прийомів гри. Після педагогічного експерименту, який тривав шість місяців, у юнаків експериментальної групи відмічається зменшення кількості помилок під час виконання ігрових дій, підвищення ефективності нападу та захисту у порівнянні зі змінами, що відбулися у показниках ігрової діяльності спортсменів контрольної групи.
Одноцикловое построение тренировочного процесса в хоккее на траве
Authors: Kostiukevych V.M.
Published: April 2023

В статье анализируется одноцикловое построение тренировочного процесса спортсменов высокой квалификации в хоккее на траве в течение года. Определены структура и содержание подготовительного, соревновательного и переходного периодов годичного тренировочного цикла. Планирование тренировочного процесса в каждом из этих периодов должно осуществляется с учетом методических подходов и принципов теории периодизации спортивной тренировки.
Применение системного анализа в научных иссделованиях в области спорта
Authors: Kozina Zh. L. , Ryepko O.A. , Kozin S.V. , Cieślicka M. , Muszkieta R.
Published: April 2023

Цель работы состояла в определении алгоритма системного анализа индивидуализации процесса подготовки спортсменов на основе общих естественно-научных закономерностей в природе. Материал и методы. Методы исследования: теоретический анализ литературных данных, методы педагогического тестирования, педагогический эксперимент, физиологические, биохимические, психофизиологические методы исследования, методы математической статистики. Результаты. Показано, что создание эффективных индивидуальных программ подготовки спортсменов требует применения системного анализа различных аспектов функционирования организма. Основные закономерности развития спортсмена или команды повторяют общие закономерности развития сложных систем в живой и неживой природе. Для анализа спортсмена как системы и создания индивидуальных программ подготовки необходимо опираться на структуру подготовленности и закономерности динамики игровой результативности. Выводы. Применение индивидуальных программ подготовки в сочетании с универсальными методами индивидуализации повышает эффективность соревновательной деятельности.
Реабілітаційний потенціал хворих з міофасціальним синдромом при периферичній формі розсіяного склерозу
Authors: Lysenko Yu.O.
Published: April 2023

Мета дослідження – виявити суб’єктивно-об’єктивні показники для розподілу пацієнтів з міофасціальному больовому синдромі асоційованого з розсіяним склерозом на окремі групи за величиною їх реабілітаційного потенціалу. Матеріал і методи. Обстежені 50 чоловіків і 55 жінок (разом 105 хворих) у віці від 26 до 55 років, у яких діагностований розсіяний склероз у поєднанні з міофасціальним больовим синдромом, який було верифіковані за даними клінічного та електроміографічного обстеження. Розподіл на рівні реабілітаційного потенціалу проводили за шкалою ВАШ, Ашворт і Вейсс, визначенням м’язової сили за Хабіровим і за Потехіним, кількістю та періодичністю загострень та електроміографічними показниками: амплітудою М-відповіді, швидкості проведення нервового імпульсу, швидкості F-хвилі і Н-рефлексу. Результати. Проведене дослідження з реєстрацією електрофізіологічних характеристик важкості і динаміки розвитку неврологічного дефіциту внаслідок розсіяного склерозу, свідчать про доцільність застосування реабілітаційного моніторингу у хворих з міофасціальним больовим синромом за величиною їх реабілітаційного потенціалу. Отримані результати служать обгрунтуванням для введення в практику реабілітаційних заходів кріотерапії (з високим потенціалом) та її поєднання з акупунктурною стимуляцією (з середнім потенціалом) і комплексним застосуванням з розтягуванням антигравітаційної групи м’язів (з низьким потенціалом) як адекватний метод реабілітації таких хворих. Висновок. Рекомендовані схеми визначення рівня реабілітаційного потенціалу з адекватним призначенням окремих чи комплексних заходів дозволяють зменшити неврологічний дефіцит при міофасціальному больовому синдромі асоційованого з розсіяним склерозом.
Застосування нетрадиційних оздоровлювальних систем у психофізичній рекреації
Authors: Musiyenko O.V. , Lemeshko O.S.
Published: April 2023

Здоров’я нації існує у вигляді певної норми плину поколінь, яка зберігає певний рівень достатності здоров’я. Здоров’я нації виявляється тісно пов’язаним з нормою розвитку суспільного інтелекту, освіти, науки, культури, фізичного виховання і спорту. Нова парадигма здоров’я формується у суспільстві вченими в галузі медицини, психології, педагогіки. В даний час спостерігається активний пошук найбільш ефективних форм і методів укріплення здоров’я населення нашої країни засобами фізичної культури, зокрема – фізичної рекреації. Досліджено рівень реактивної і особистісної тривожності, а також емпатійні тенденції осіб, які займались Хатха-Йогою. Виявлено позитивний ефект застосування оздоровчої системи Йоги як засобу психофізичної рекреації для профілактики психоемоційного напруження, розвитку особистісних якостей, відповідно, гармонійного вдосконалення особистості.
Explanation Of E-Service Quality and Actual Use of M-Banking
Authors: Shafira Az-Zahra Shafira Az-Zahra , Setiawati Lina , Sosianika Adila , Senalasari Widi
Published: April 2023

Technological developments are increasingly rapid from time to time, causing all areas of the business sector to be required to be adaptive. One of which is the banking sector. The digital era has made mobile banking an option to facilitate transaction activities. The actual use of mobile banking is a real-world interpretation to explain the impact of electronic service quality more comprehensively. This study aims to explore mobile banking users in Indonesia. The quality of e-service in mobile banking uses the Technology Acceptance Model (TAM) approach. With total of 202 mobile banking users in Bandung as respondents; the data were analyzed using SMART PLS with the methods of reliability test, validity test, hypothesis test, and mediation analysis to be able to interpret the research objectives more specifically. The findings indicate e-service quality significantly impacts attitudes towards m-banking, perceived usefulness, and perceived ease of use. It points out that internet-based transactions, especially mobile banking systems, should be made easier, safer, and more convenient for consumers to use.
Responsive Strategy of Courier Services Companies on Handling Customer Complaint in Social Media: The Effect on Brand Trust and Customer Loyalty
Authors: Kania Rafiati , Salsabila Hanumsari Nurul
Published: April 2023

This study aims to research how potential customers evaluate courier service brand responses to customer complaints on social media that influence consumer trust and loyalty. Integrating the literature on perceived justice in service recovery and brand feedback in social media communication, this study examines the effect of brand feedback, procedural justice, and interactional justice in the company response to customer complaints on potential customer trust in the brand (brand trust) and customer loyalty toward the courier service brand. A total of 333 respondents participated in this survey and confirmed the research model by the PLS-SEM method as data analysis. The main result includes the two-way interaction effect of brand feedback and procedural justice on trust and the mediating effect of brand trust on customer loyalty. However, the interactional justice effect becomes insignificant in influencing trust and customer loyalty. This study provides practical implications for courier service companies on how to effectively respond to customer complaints on= social media.
Social Media User Perception on Communication Types: Comparing One-Two Way of Communicating Brand
Authors: Gunawan Arie Indra , Monoarfa Hilda , Hendrayati Heny , Bahri Khoirun Nisa , Rahayu Agus , Huda Miftakul
Published: April 2023

Social media is a communication medium expected to create brand satisfaction and trust. If we attempt to classify communication patterns and intensity on Instagram media, there are one- and two-way communication patterns. Some posts do not require confirmation, and the goal is not to create a conversation between the messenger and the audience. This condition creates a knowledge gap in marketing communications that need to be known empirically. This research was conducted with a quantitative approach - descriptive statistics. Research data was collected by distributing questionnaires through communication and sending messages to Instagram accounts. 249 data are obtained and analyzed using Warp-PLS. The research findings show that one-way communication patterns are more effective in creating brand trust. The audience considers information conveyed in this pattern more effective and valid because they are not distracted by multi-respondent conversations, which often extend from information topics. This study has implications for theoretical contributions to creating brand satisfaction and trust and for the company's communication strategy to deliver brand communications to the audience. Also, companies can vary their communication patterns on social media, especially Instagram, from the audience that continues to respond (further conversations occur)
The Perception of Young Women towards Beauty Value in Beauty Advertisements
Authors: Amalia Fatya Alty , Andani Adiva Rakhma , Guteres Alexandre Desausa
Published: April 2023

Fulfillment of beauty standards with a thin body, fair skin, and straight hair should have status as an old idea that does not need to be perpetuated. There is a change from women who no longer interpret beauty according to the standards that are instilled. This is in line with the many brands that are starting to break the stereotype of beauty when creating their campaigns and advertising media, with values that are increasingly changing, now many beauty brands have created positive and inclusive campaigns to touch more people who care about physical and non-physical beauty. The current study aims to know how female customers perceive the value of beauty toward the ideal women that are being promoted in media, especially in advertising, and how its impacts women. To explore the perceptions of women as a customer, this study uses a qualitative method to dig deeply into how the perception of the customer will work against the brands. This study suggests that brands, especially beauty brands, to put attention to female customers’ perception of how they want to appear in any media that exist. Instead of focusing on idealized women, brands should use a more natural model which might bring inclusion and diversity.
Shipwrecks of Feasibility in the Field of Investment Business
Authors: Parashtheo Bintang , Cahyono Akhmad Budi
Published: April 2023

Indonesian Valuable Objects on the Load of Sinking Ships (BMKT) have a large potential. This makes the ships buried in Indonesian territorial seas a tremendous resource. Illegal treasure hunters have targeted Indonesia's BMKT because to its great potential, causing considerable losses.  Realizing this, it is vital to pay attention to Valuable Items on the Load of Sinking Ships (BMKT) and develop rules to maximize their potential. This study aims to analyze the policies governing BMKT to support investors in participating in investing in the business sector of BMKT management and creating BMKT management that is optimal and feasible for all aspects of the values contained in the BMKT itself. The approach method used to achieve this research is an approach focused on regulations or policies (statute approach) and conceptual analysis. The result showed that there is still substantial overlap between regulations controlling BMKT, making BMKT administration feasible. In spite of this, the Economic Analysis of Law is used to explain the expansion of the legal dimension through its studies. In addition, the economic value and cultural legacy of BMKTs that cannot be appointed due to the difficulties of appointment or the impossibility of relocation may be used on-site via marine tourist activities, notably diving tourism. As such, investors who wish to participate in the business sector of BMKT management may use BMKT more properly and optimally, including local and international investors.
Actual aspects of surgical treatment of the mediagastric malignant tumors, complicated by bleeding and perforation
Authors: Ivanchov P.V. , Prudnikova O.B.
Published: April 2023

The aim of the work is to improve the results of surgical treatment of mediogastric malignant tumors complicated by bleeding, perforation and stenosis. During the period 2006–2020, the clinic treated 766 patients with malignant stomach tumors complicated by gastrointestinal bleeding and perforation. Malignant mediogastric tumors were diagnosed in 227 (29.6%) patients, in particular complicated by bleeding – in 212 (93.4%), perforation – in 9 (4.0%), perforation and bleeding – in 6 (2.6%) patients. In total, 106 (46.7%) among 227 patients were operated on, in particular, 13 (12.3%) patients underwent emergency surgery for tumor perforation, and in the group with newly detected cancer operative activity was 48.7% (56 out of 115). Radical operations were performed in 75 (70.8%) patients, palliative and symptomatic – in 31 (29.2%) patients. The total postoperative mortality was 6.6% (7 patients). After radical surgical interventions, 2 (1.9%) patients died, and after palliative and symptomatic operations – 5 (4.7%) (2 (40.0%) of them were operated on for tumor perforation, diffuse peritonitis). It was established that the mortality after emergency operations (22.2%) at the height of ongoing and recurrent bleeding is 4.0 times higher than after operations performed in the early delayed period (5.6%), which are performed after adequate preparation and comprehensive follow-up examination of patients. Therefore operations at the height of bleeding in patients with acutely bleeding malignant mediogastric tumors to be too dangerous, which is associated with high postoperative mortality. In the case of perforation of the tumor, it is advisable to perform palliative or symptomatic surgical interventions at the first stage in order to save the patient's life, followed by delayed (1.5–2 months) radical surgical intervention with lymphodissection D2.

Keywords: malignant stomach’s tumors, endoscopic hemostasis, radical operations, palliative operations, symptomatic operations.
Perfeccionando los exámenes escritos: reflexiones y sugerencias metodológicas
Authors: Hernández Nodarse Mario
Published: April 2023

Actualmente, uno de los centros del debate acerca de la evaluación del aprendizaje, gira en torno de los exámenes. El desarrollo de las ciencias y la tecnología, promueve nuevas inquietudes: ¿Deben ser eliminados los exámenes escritos? ¿Pueden estos instrumentos contribuir a la obtención de juicios valorativos fiables acerca del desarrollo del aprendizaje de los alumnos? ¿Pueden impulsar significativamente los aprendizajes en correspondencia con las necesidades individuales y con las finalidades formativas generales de la educación? Este trabajo, ofrece algunas reflexiones y sugerencias metodológicas fundamentadas, que contribuyen a mejorar la elaboración y la aplicación de dichos instrumentos, sustentado en concepciones formativas contemporáneas.
Las nuevas tecnologías y el aprendizaje de las matemáticas
Authors: Macias Ferrer David
Published: April 2023

Es evidente el acelerado desarrollo de la tecnología. El lenguaje y la comunicación no han escapado ante los cambios. Han existido cambios radicales en el lenguaje escrito y ahora éste, ha revolucionado con la era de la electrónica y la computación; surgen las llamadas nuevas tecnologías de la comunicación y la información (NTCI) y por extensión los medios informáticos, y su principal instrumento: la computadora. Hipertexto, multimedia, hipervínculos e hipermedia son términos que pertenecen a un nuevo bagaje cultural en una sociedad afectada por las nuevas tecnologías y que se han introducido desde hace varios años en México dentro del ámbito educativo. Dentro del marco de las nuevas posibilidades que ofrecen los recursos hipermediales junto con dos de sus características esenciales, la visualización y la interactividad, se desarrolla uno de los factores esenciales de la enseñanza: el aprendizaje y en particular el de las matemáticas.
Um olhar retrospectivo sobre a avaliação externa no Brasil: das primeiras medições em educação até o SAEB de 2005
Authors: Horta Neto João Luiz
Published: April 2023

Neste trabalho serão apresentados alguns fatos considerados marcantes na evolução da avaliação educacional no Brasil, desde a realização dos primeiros levantamentos de dados educacionais no início do século XX, passando pela institucionalização do Ministério da Educação como órgão responsável pela administração da política educacional nacional e a criação do Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira – INEP. São apresentadas algumas das diferentes funções a ele atribuídas ao longo de sua existência, até se tornar uma autarquia responsável pelos levantamentos educacionais do Ministério da Educação. São também apresentados os principais acontecimentos que deram origem ao Sistema de Avaliação da Educação Básica – SAEB, desde os primeiros estudos, ainda em 1988, até os dias atuais, inclusive situando-os dentro do contexto mundial.
Las tareas comunicativas en el aprendizaje de lenguas extranjeras: una alternativa para el desarrollo de habilidades comunicativas
Authors: Benítez Menéndez Orquídea
Published: April 2023

El proceso de enseñanza-aprendizaje de lenguas extranjeras ha sido objeto de disímiles investigaciones a lo largo del tiempo. Los estudios acerca de cómo se enseñan y se aprenden las lenguas han ido progresando, cambiando de orientación en función de los diferentes estadíos del desarrollo científico intelectual y de las necesidades que exige el desarrollo social.

Las lenguas como fenómeno social evolucionan y se desarrollan. El inglés no solo ha evolucionado en relación con su extensión en el mundo, sino que como consecuencia, se han modificado los perfiles sociolinguísticos de quienes lo estudian, de quienes lo enseñan y por supuesto de quienes lo aprenden. En los inicios del tercer milenio, el desarrollo científico-tecnológico, la globalización como fenómeno social y el ingente desarrollo de las tecnologías de la comunicación han propiciado un contexto diferente para la enseñanza-aprendizaje de la lengua inglesa. En todos los procesos de enseñanza-aprendizaje se habla hoy en términos de eficiencia, lograr un aprendizaje eficiente de una lengua extranjera implica indudablemente la habilidad de utilizar la lengua que se aprende con fines comunicativos reales.