bluuebunny/crossref_metadata_2025 huggingface dataset:
Automating Drug Discovery using Machine Learning
Authors: Abdul Raheem Ali K. , Dhannoon Ban N.
Published: June 2023

Drug discovery and development have been sped up because of the advances in computational
science. In both industry and academics, artificial intelligence (AI) has been widely used. Machine
learning (ML), an important component of AI, has been used in a variety of domains, including
data production and analytics. One area that stands to gain significantly from this achievement of machine
learning is drug discovery. The process of bringing a new drug to market is complicated and
time-consuming. Traditional drug research takes a long time, costs a lot of money, and has a high failure
rate. Scientists test millions of compounds, but only a small number make it to preclinical or clinical
testing. It is crucial to embrace innovation, especially automated technologies, to lessen the complexity
involved in drug research and avoid the high cost and lengthy process of bringing a medicine
to the market. A rapidly developing field, a branch of artificial intelligence called machine learning
(ML), is being used by numerous pharmaceutical businesses. Automating repetitive data processing
and analysis processes can be achieved by incorporating ML methods into the drug development process.
ML techniques can be used at numerous stages of the drug discovery process. In this study, we
will discuss the steps of drug discovery and methods of machine learning that can be applied in these
steps, as well as give an overview of each of the research works in this field.
Predicting Intention for Food Safety Behavior among Food Handlers:
A Cross-sectional Study in Indonesia’s Beach Culinary Area
Authors: Rustiawan Asep , Sulaeman Endang Sutisna , Suminah Suminah , Mulyani Sri
Published: June 2023

Background:

The food safety behavior of food handlers constitutes the main factor in
foodborne disease control. According to the Theory of Planned Behavior, behavior is determined by
the intention that is established from a combination of attitudes, subjective norms, and perceived
behavioral control. This research aimed to predict the intention for food safety behavior using the
Theory of Planned Behavior.

Methods:

A cross-sectional study was conducted for two months in the Bantul beach culinary area,
Yogyakarta, Indonesia. The research population consisted of 80 food handlers representative of all
existing seafood stalls. The respondents were interviewed face-to-face using a paper-based questionnaire
related to attitudes, subjective norms, perceived behavioral control, and intention. The data
collected were evaluated using structural equation model-partial least square (SEM-PLS), version
3.0, with a sig. level of 0.05.

Results:

This research successfully predicted 64.3% of the variance in the intention for food safety
behavior of food handlers (R2 adjusted = 0.643). The variable-perceived behavioral control was the
strongest and most significant predictor, with a positive effect on intention for food safety behavior
(β = 0.560, p = 0.000 < 0.05), followed by the variable subjective norms (β = 0.275, p = 0.001 <
0.05). The variable attitude was the weakest predictor, with an insignificant positive effect (β =
007.0, p = 0.182 > 0.05).

Conclusion:

This research successfully predicted the intention for food safety behavior of food
handlers in the Bantul beach culinary area, Yogyakarta, Indonesia.
A Review of In Vitro Antimicrobial Activities of Carbazole and its
Derivative From 2014 to 2022
Authors: Kumar Nitin , Sharma Shalini , Nirmal Puneet
Published: June 2023

A large number of antibiotics are easily accessible for the treatment of various micro-bial infections. However, antibiotic resistance has become a major concern to public health across the globe. Carbazole derivatives are present in carbazomycins, an unprecedented class of antibiotics showing potential antibacterial activities. As reported in the literature, carbazole de-rivatives also possess significant antimicrobial activities against bacterial resistance, such as Methicillin Resistant Staphylococcus aureus (MRSA). The antimicrobial profile of carbazole derivatives has been achieved through various bacterial pathways. Carbazole hybrids based on the multi-target direct ligand (MTDL) approach were also extensively studied as they exhibited significant antibacterial activities. This article reviews antimicrobial potential, docking analysis, and structure-activity relationship (SAR) studies of carbazole and its derivatives against tested bacterial strains from 2014 to 2022. This review can also be helpful for investigators in the de-sign and development of new molecules based on carbazole structure against various resistant bacterial infections.
Characterization and In-vitro Study of Micro-encapsulation Chitosan
Alginate of Single-bulb Garlic Extract
Authors: Lestari Sri Rahayu , Gofur Abdul , Hartatiek Dra. , Annisa Yuslinda , Ramadhani Dimas Nur , Rahma Amalia Nur , Aisyah Dahniar Nur , Mufidah Ikfi Nihayatul , Dini Rifqi Nadiya
Published: June 2023

Background:

Single-bulb garlic extract (SBGE) contains more active compounds than regular
garlic, but it is unstable and easily degraded in the digestive tract. SBGE is expected to be protected
by microencapsulation chitosan-alginate (MCA).

Objective:

The present study aimed to characterize and assess the antioxidant activity, hemocompatibility,
and toxicity of MCA-SBGE in 3T3-L1 cells.

Methods:

The research procedures consist of extraction of single bulb garlic, preparation of MCASBGE,
Particle Size Analyzer (PSA), FTIR analysis, DPPH assay, hemocompatibility test, and MTT
assay.

Results:

The average size of MCA-SGBE was 423.7 ± 2.8 nm, the polydispersity index (PdI) was 0.446
± 0.022, and the zeta potential was -24.5 ± 0.4 mV. MCA-SGBE was spherical with a diameter range of
0.65-0.9 μm. A shift in absorption and addition of functional groups was found in SBGE after encapsulation.
MCA-SBGE, at a concentration of 24 x 103 ppm, has higher antioxidants than SBGE. The hemocompatibility
test shows the hemolysis of MCA-SBGE lower than SBGE. MCA-SBGE was not toxic to
3T3-L1 cells with cell viability percentage above 100% at all concentrations.

Conclusion:

MCA-SBGE characterization has microparticle criteria with homogeneous PdI values, low
particle stability, and spherical morphology. The results showed that SBGE and MCA-SBGE are nonhemolytic,
compatible with red blood cells, and non-toxic to 3T3-L1 cells.
Agricultural and Veterinary Pesticides Residues in Human Food
Authors: Khattabi Latifa , Mokhtari Moussa , Bouhenna Mustapha Mounir , Fellak Ahmed , Abu-Mustapha Mohamed , Akkal Saleh , Sellam Feriel
Published: June 2023

Introduction:

Expanding utilization of pesticides can provoke serious issues due to their biomagnification and persistent nature. Eventual contamination of fresh daily-consumed food by pesticide
constitutes a human food security problem.

Methods:

The present investigation planned to check out whether the most hazardous pesticides could be
found in a varied collection of wheat, vegetables and fruit, on the other hand, we attempted to know if
some banned and no more commercialized pesticides could be even detected. Effectively, we have chosen
to analyze wheat, potato, tomato, apple, peach and grape, so, after the extraction procedure of pesticides,
we used gas chromatography-mass spectrometry (GC-MS) to identify some hazardous compounds (organochlorines and organophosphorus). These compounds were used as standards to generate calibration
curves and estimate precisely their concentration in the tested samples using selected ion monitoring
(SIM) mode.

Results:

The results have shown the presence of an important quantity of pesticides that are no more used
(banned) for decades for agriculture purposes but they are still used as veterinary drugs, such as lindane
(0.2 ppm grape, 0.32 ppm tomato) and fenchlorphos (0.5 ppm grape).

Conclusion:

This survey should be routinely executed by scientists and concerned authorities to control
pesticides circulation with their exact amounts in food and other environmental matrices as well as eventual contamination with another toxic element.
Pengembangan LKPD Berbasis Literasi Konten Kearifan Lokal pada Materi Asam dan Basa
Authors: Saputri Febri , Laksono Endang Widjajanti
Published: June 2023

Penelitian pengembangan ini dilakukan dengan tujuan: (1) menghasilkan produk Lembar Kerja Peserta Didik (LKPD) materi asam basa yang mengacu pada model pembelajaran Student Team Achievement Divission (STAD) berbasis literasi konten kearifan lokal sesuai dengan kekhasan yang dibuat; (2) mengetahui kelayakan LKPD yang dihasilkan berdasarkan penilaian lima guru kimia SMA; (3) mengetahui respon peserta didik terhadap produk melalui uji keterbacaan oleh peserta didik. Prosedur pengembangan mengacu pada model pengembangan 4D. Tahap yang dilakukan antara lain: (1) Define (pendefinisian); (2) Design (perancangan); (3) Development (pengembangan); (4) Disseminate (penyebaran). Hasil validasi oleh dosen ahli pembelajaran kimia LKPD ini layak digunakan setelah direvisi berdasarkan saran penilai. Hasil penilaian kualitas produk LKPD oleh reviewer  memperoleh  persentase keidealan 88,00% dan hasil uji keterbacaan oleh peserta didik memperoleh   persentase keidealan sebesar 83,31%, sehingga secara keseluruhan LKPD ini layak digunakan pada pembelajaran kimia.Kata Kunci: LKPD, STAD, literasi, kearifan lokal, asam basa.
Pengembangan E-Modul Berbasis Model Pembelajaran Discovery Learning Menggunakan Powerpoint dan Flip Pdf Corporate Pada Materi Alat Optik
Authors: Ramadhan Galih , Maulidah Rifa'atul
Published: June 2023

Tujuan penelitian ini adalah untuk mengetahui tingkat kevalidan dan kepraktisan E-Modul berbasis model pembelajaran Discovery Learning menggunakan Powerpoint dan Flip Pdf Coorporate pada materi Alat Optik. Jenis penelitian adalah penelitian Research and Development (R D) dengan menggunakan model pengembangan Analysis, Design, Development, Implementation, Evaluation (ADDIE). Teknik pengumpulan data meggunakan wawancara kepada satu guru fisika SMA Negeri 1 taraju, angket uji validitas kepada tiga ahli, angket kepraktisan kepada 64 siswa SMA Negeri 1 Taraju dan satu guru fisika SMA Negeri 1 Taraju. Hasil penelitian menunjukan bahwa rata-rata persentase validasi ahli materi sebesar 81% dengan kriteria sangat valid, persentase validasi ahli media sebesar 82% dengan kriteria sangat valid, persentase validasi ahli bahasa sebesar 88% dengan kategori sangat praktis. Hasil uji kepraktisan siswa mendapatkan persentase 83% sedangkan hasil uji kepraktisan guru mendapatkan persentase 89% dengan kategori sangat praktis. E-Modul yang dikembangkan memenuhi kriteria sangat valid dan praktis untuk digunakan dalam proses pembelajaran.Kata Kunci: Alat Optik, E-Modul, Flip Pdf Corporate, Powerpoint
Specialized Content Knowledge Lower Secondary School Teachers on Quadrilaterals
Authors: Pagiling Sadrack Luden , Nur'aini Khumaeroh Dwi
Published: June 2023

The teachers' knowledge of specific content has a positive relationship with the students' mathematics achievement. Mathematics teachers must have an appropriate level to ensure mathematics learning effectively. The quadrilateral is one of the essential contents in geometry.  However, many teachers did not successfully deliver and teach this content in classroom instruction. Therefore, this qualitative study explores the specialized content knowledge of lower secondary teachers in defining and classifying quadrilaterals. Four teachers, two male and two female teachers, were recruited to become participants in this work. All participants have similar teaching experience and do not hold an educator certificate. A test and semi-structured interviews were assigned to obtain specialized content knowledge of the teachers on quadrilaterals. The interview data were analyzed in three stages: data condensation, data presentation, and conclusion drawing. The findings show that only one teacher understands hierarchically in defining and classifying quadrilaterals, two teachers are at the partial prototype level because they cannot see the hierarchical relationship between the quadrilaterals, and another teacher is at the prototype understanding level because it relies on the prototype of quadrilaterals' shape. These findings suggest that lower secondary teachers' special content knowledge of quadrilateral needs to be strengthened through workshops and training professional development.
Pengembangan Bahan Ajar Matematika Berbasis Kontekstual
Authors: Mahmudi Ali , Sugiman Sugiman , Hernawati Kuswari , Lestari Himmawati Puji
Published: June 2023

Penelitian pengembangan ini bertujuan untuk mengembangkan bahan ajar matematika berbasis kontekstual yang valid, praktis, dan efektif dengan model pengembangan ADDIE yang terdiri atas lima langkah pengembangan, yaitu Analysis, Design, Development, Implementation, dan Evaluation. Pengembangan bahan ajar ini penting untuk memfasilitas siswa dalam membangun pemahaman dan kebermaknaan dalam belajar matematika yang terjadi ketika siswa memahami keterkaitan antara suatu pengetahuan dengan pengetahuan lain atau dengan konteks kehidupan sehari-hari. Pembelajaran kontekstual dilaksanakan dengan strategi REACT yang terdiri atas lima aktivitas produktif, yaitu relating (mengaitkan materi pembelajaran dengan konteks), experiencing (melakukan eksplorasi untuk menemukan konsep atau pengetahuan), applying (menerapkan pengetahuan yang telah dikonstruksi), cooperating (bekerjasama untuk menyelesaikan masalah), dan transferring (menerapkan pengetahuan pada situasi atau masalah baru). Struktur penyajian bahan ajar ini diawali dengan penyajian konteks atau masalah yang sesuai dengan suatu konsep. Pemahaman dan penyelesaian terhadap masalah tersebut dijadikan dasar untuk membahas konsep-konsep matematis. Bahan ajar juga dilengkapi dengan berbagai soal-soal latihan yang berupa masalah kontekstual untuk memfasilitasi siswa untuk mengaplikasikan konsep. Insrumen penelitian ini adalah lembar kevalidan bahan ajar, angket kepraktisan bahan ajar, angket respon siswa terhadap bahan ajar, dan tes hasil belajar matematika. Hasil penelitian ini adalah bahan ajar matematika berbasis kontekstual yang valid, efektif, dan praktis.Development of contextual mathematics teaching material AbstractThis development research aims to develop mathematics contextual teaching materials that are valid, practical, and effective with the ADDIE development model consisting of five development steps, namely Analysis, Design, Development, Implementation, and Evaluation. The development of the teaching materials is important to facilitate students in building meaningfulness in learning mathematics. Meaningfulness can be obtained when students understand the relationship between concepts with other concepts and with the context in everyday life. Contextual learning is implemented with a REACT strategy consisting of five productive activities: relating, experiencing, applying, cooperating and transferring. The structure of contextual-based mathematical teaching materials begins with an exploration of the context or problem as a basis for constructing a mathematical concept. Teaching materials are also equipped with various problems of contextual problem solving as a concept application that has been constructed. The instrument of this research is the validation sheet, the instrument of the practicality of the teaching materials, the questionnaire of the students’ response to the teaching materials and the test of achievement. The results of this study are mathematics contextual materials that are valid, effective and practical.
Association of adverse childhood experiences with health-related behaviors and mental health among adults in China: findings from the China Health and Retirement Longitudinal Study (Preprint)
Authors: You Yueyue , Yu Shunfei , Guo Jiadi , Xuan Zhiqiang , Hao Xiaoji
Published: June 2023

BACKGROUND

Adverse childhood experiences (ACEs) refer to some of the most intensive and frequently occurring sources of stress that children may suffer early in life. There is an extensive amount of literature reporting the negative impact of ACEs on adults’ mental health. However, evidence on the association between ACEs and health-related behaviors and mental health, using a nationally representative survey of Chinese people is relatively scarce.

OBJECTIVE

This study investigated the association of ACEs with health-related behaviors and mental health and the independent effect of ACE components.

METHODS

We analyzed data for 10119 adults from the 2015 China Health and Retirement Longitudinal Study (CHARLS) and the 2014 CHARLS life history survey. Twelve ACE indicators were collected via a self-reported questionnaire. Health-related behaviors (i.e. binge drinking, heavy drinking, smoking, insufficient and long sleep) and mental health (i.e. loneliness, social isolation, and life satisfaction) were measured via a self-reported questionnaire. Multiple logistic regression and linear regression assessed the association of ACE score categories and individual ACE components with outcomes.

RESULTS

A total of 79.5% (8041/10119) of participants reported at least one ACE and 11.9% (1209/10119) reported experienced four or more ACEs. Compared with individuals without ACE, those who experienced four or more had a higher risk of heavy drinking (OR=1.47, 95%CI: 1.17, 1.83), insufficient sleep (OR=1.54, 95%CI: 1.31, 1.83), loneliness (OR=1.87, 95%CI: 1.54, 2.27), more social isolation (β=0.10, 95%CI: 0.01, 0.16), and lower life satisfaction (β=-0.20, 95%CI: -0.25, -0.15). Trend analyses showed a dose-response association of ACEs with outcomes (all P<0.001). Additionally, the individual components had different effects on health-related behaviors and mental health.

CONCLUSIONS

Our findings indicated that there is a cumulative effect of ACEs on heavy drinking, insufficient sleep, loneliness, social isolation, and life satisfaction. Individual ACE components have differential relationship with health-related behaviors and mental health. Childhood experiences are a good target for preventing adult health-related behaviors and mental health programs.
Adrenaline Intolerance in ASD Curing From Autoimmune Pathogens — Sebaceous Immunobiology in Autoimmune Pathogen Research (Preprint)
Authors: Pachankis Yang
Published: June 2023

UNSTRUCTURED

The review is summarative to the clinical trials numbered NCT05711810 and NCT05839236 on ClinicalTrials.gov, with the sole participant's recovery from autoimmune pathogens who was also diagnosed as neurodivergent during the first interventional trial. The review seeks to bridge the literature gaps between psychiatry and the medical sciences on neurodiversity with the focus on immunobiology. It chooses the concept of adrenaline intolerance during the final phase of the recovery process to summarize the clinical evidences. The first part of the review synthesizes the key locations of autism spectrum disorder (ASD)'s neurological differences to neurotypical individuals. With the anatomic overview, the second part reviews the relevances to the immune system and implications in immune reflex. The third part reviews the neuroatypical hormonic paths based on the ASD participant's data, whereby the final recovery process with hypolipidemic agent intervention posed a contradiction between the neuronal needs and autoimmune needs of the participant's internal conditions. The review predicts that the contradiction offers a new window into the study of sebaceous immunobiology.
Pollution Reduction and Economic Growth —A Small Town’s Journey to Sustainable Development
Authors: Dong Lily , Zhou Zhaoxi
Published: June 2023

It’s commonly believed that one can do well by doing good. When applied to business, the concept means that an environmentally friendly and responsible business can also do well in regards to profit. Or, if a state or region devotes resources to improving the environment, the economic growth will be strengthened. This concept echoes the essential meaning of the famous quote by China’s leader, “Clean waters and green mountains mean mountains of gold and silver.” Is this theory true in the real world? We intend to investigate the case of a small rural town from northern China which went from a heavily polluted town with small businesses scattered around, to today’s paradise with clean waters, green parks, and sustainable agro-farms. The town went from a poor rural town with low GDP before the 1990s to boomed economy in early 2000s, when the heavy pollution imposed a threat to the health of local residents. After almost two decades of government intervention, the town has transformed into a clean and sustainable community with public parks and agro-tourism based farms.Our paper intends to take a close look at the transformation process, and describe key factors of success, and identify areas for improvement. We also attempt to provide implications for future research, and recommendations for policy makers.
ASSESSMENT OF POSTPARTUM DEPRESSION IN A TERTIARY CARE INSTITUTE
Authors: Anju  , Gupta Rajat , Kaur Parneet
Published: June 2023

Introduction: India is in a state of obstetric transition, where indirect causes of maternal morbidity and mortality are now more common. Depression is one such entity that goes unscreen and untreated, contributing to maternal morbidity.
Objective: The study aimed to find the incidence of postpartum depression (PPD) in a tertiary care institute and determine the associated risk factors contributing to PPD.
Methods: This was a prospective cross-sectional study conducted in the Department of Obstetrics and Gynecology, Government Medical College and Rajindra Hospital, Patiala, from June 1, 2020 to July 31, 2022. All the patients who were in the postpartum period and gave consent were included in the study. They were subjected to the Edinburgh Postnatal Depression Scale (EPDS) questionnaire, and their responses were recorded. The same patients were subjected to the same EPDS questionnaire at 6 months, and the score was calculated. A score of more than or equal to 12 was considered statistically significant for depression, and patients were referred to a psychiatrist for further evaluation and management.
Results: In total, 102 were enrolled in the study. The incidence of PPD in the study participants was 12.75% at the immediate postparity period and 15.69% at 6 months postpartum. Husband’s unemployment (p<0.05), low family income (p<0.05), unplanned pregnancy (p<0.05), development of antenatal complications (p<0.05), lack of regular ANC care (p<0.05), neonatal death (p<0.05), bad relationship with in-laws (p<0.05), and low self-esteem (p<0.05) were the main contributors to the development of PPD in both immediate postpartum period as well as at 6 months postpartum. Only four patients agreed to visit the psychiatrist, the rest refused the evaluation and treatment.
Conclusion: In India, despite the National mental health program 1983, maternal mental health is still not a prominent component of the program which needs to be included. Screening tools should be used to identify and treat women.
FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF REPAGLINIDE
Authors: Begum Asma , RANI G UMA
Published: June 2023

Objective: The present study’s is to develop floating drug delivery system of repaglinide.
Methods: Moringa gum, Repaglinide, HPMC K100M, Sodium alginate, Calcium Carbonate, Sodium Citrate. The obtained formulation was evaluated for drug content, pH, in vitro gelling capacity, in vitro buoyancy studies, and in vitro dissolution studies.
Results and Discussion: All the total F1-F12 formulations showed pH ranging from 5.1 to 7.9, floating lag time of F1-F12 ranging from 5 s to 12 s with total floating time greater than 12 h, viscosity of F1-F12 ranging from 619 to 3856 cp, drug content of F1-F12 ranging from 31.2% to 93.1%, and percent drug release of F1-F12 ranging from 78.9% to 93.9%. Dissolution studies showed that F12 formulation-containing drug (30 mg) and polymer (4000 mg) showed 93.9% drug release in 12 h which is said to be optimized. Thus, the best formulation (F12) was subjected for a 3-month period of stability studies found to be stable and reported no significant change.
Conclusion: The study’s goal is to develop and evaluate floating in situ gel forming solution of repaglinide with moringa gum as rate retardant polymer.
ROLE OF PLATELET INDICES IN DENGUE FEVER CASES IN CORRELATION WITH SEROLOGICAL MARKERS – A STUDY OF 100 CASES
Authors: K Srikanth reddy , V Bharadwaj , Naidu Sree Ramulu
Published: June 2023

Objective: This study aims to evaluate the utility of various platelet indices, i.e., platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in dengue fever and to study different serological markers (NS1 Ag, IgM, and IgG) and compare them with platelet counts.
Methods: This was a retrospective, observational, and cross-sectional study done over 6 months. A total of 100 cases with symptoms of dengue and seropositive for any of the rapid tests (NS1 Ag, Ig M, and Ig G antibodies) were included. Platelet count, MPV, (PDW), and (PCT) were determined using six-part Hematology analyzer. Based on the platelet count, all dengue seropositive cases were divided into 5 groups, and platelet indices were analyzed and tested for statistical significance using Chi-square test and Anova test.
Results: Thrombocytopenia was more common in the NS1 Ag-only reactive cases. Dengue hemorrhagic fever (DHF) cases (12) had significantly low MPV, high PDW, and low PCT. Statistical analysis between mean MPV, mean PDW, mean PCT, and platelet count among various groups was significant. Low MPV, high PDW, and low PCT were more evident when platelet count was < 1lakh.
Conclusion: Our study showed that thrombocytopenia was more common in the NS1 Ag-only reactive cases than other serological markers.A Low MPV with a spike in PDW, and a plummeted PCT in cases with thrombocytopenia indicate severity of dengue infection. These platelet indices act as surrogate markers in predicting the risk of bleeding.
NEED OF INTEGRATION OF COURSE ON MEDICAL DEVICES IN UNDERGRADUATE PHARMACY CURRICULUM
Authors: Kaur Sukhpreet
Published: June 2023

Medical Devices are becoming indispensable part of Indian healthcare sector. Medical Devices are multi-product sector which includes various products such as implants, consumables, IVD reagents. The market of medical devices is growing tremendously but India mainly relies on imports of these devices. Indian Government has announced Promotion of Medical Devices Parks. This will encourage setting of Med Tech Industry in India. But, India has short fall of skilled manpower to work in Med Tech Industries. Pharmacists are the main authority involved in procurement and sale of these medical devices. The current curriculums of B. Pharmacy does not include Medical Devices. A course on Medical Devices should be included in curriculum. Faculty experts in pharmaceutical sciences and regulatory officers are of the view that study of medical devices should be made a mandatory discipline for all pharmacy courses approved by the Pharmacy Council of India (PCI) because, like medicines and other health technologies, these devices are also necessary for patient care.  Equipping pharmacist with knowledge will benefit the pharmacist as well as improve patient care. Moreover, this will open a new avenue of jobs for the pharmacist.
A COMPARISON OF EFFICACY OF INTRANASAL FENTANYL AND INTRANASAL DEXMEDETOMIDINE AS PREMEDICATION IN PEDIATRIC PATIENTS
Authors: Rishikesh Premgeeth , Joseph Elizabeth , Joseph Thomas
Published: June 2023

Objective: The objective of the study was to determine the effects of intranasal fentanyl compared to intranasal dexmedetomidine, when used for relieving pre-operative anxiety in children on the basis of onset and quality of anxiolysis, parental separation, hemodynamic stability, and cooperation to mask holding.
Methods: A prospective observational study was conducted in Government Medical college Kottayam for a period of 12 months from December 2021 to December 2022, randomly assigned a total of 40 pediatric patients (the American Society of Anesthesiologists I and II) in the age group 3–6 years, undergoing elective surgeries requiring general anesthesia who received either intranasal fentanyl (group F) or intranasal dexmedetomidine (group D). Onset and quality of anxiolysis was compared using modified Yale pre-operative anxiety scale. Parental separation score, hemodynamic stability, and cooperation to mask holding were compared. Data collected were analyzed using SPSS version 25.
Results: Children who received intranasal fentanyl as premedication had better quality and onset of anxiolysis as compared to dexmedetomidine group. In parent-child separation, intranasal fentanyl was found to be better than intranasal dexmedetomidine.
Conclusion: We conclude that intranasal fentanyl is superior to intranasal dexmedetomidine in relieving pre-operative anxiety in pediatric population of age 3–6 years.
FUNCTIONAL OUTCOME OF PATIENTS WITH MODERATE-TO-SEVERE OSTEOARTHRITIS TREATED BY TOTAL KNEE ARTHROPLASTY AT A TERTIARY CARE CENTER
Authors: Patil Jaydeep , Ghorpade Kapil , Khambalkar Shouryashil , Naik Nagesh , Patil Tanish
Published: June 2023

Objectives: Osteoarthritis (OA) is one of the common causes of significant morbidity in elderly individuals. It typically manifests as painful joints affecting mobility in individuals particularly women in and after fifth or sixth decade of life. While most of the mild-to-moderate cases are managed conservatively, in severe OA total knee arthroplasty (TKA) is being increasingly done with good functional outcome. The aim of the study was to assess functional outcome in case knee OA cases treated by TKA. The study aimed to study the complication in patients undergoing TKA.
Methods: Forty patients with moderate-to-severe knee OA and treated by TKA were included in this study on the basis of a predefined inclusion and exclusion criteria. Demographic details such as gender and age were noted in all the cases. Body mass index (BMI) was determined. All patients were treated by TKA. Functional outcome was assessed by Japanese Orthopaedic Association score (JOA) as well as Functional knee clinical score (KCS). Incidence of complications was assessed during follow-up. For statistical purposes, p<0.05 was taken as significant.
Results: There were 25 (62.50%) females and 15 (37.50%) males with a M: F ratio of 1:1.66. 13 (32.50%) patients were obese (BMI≥30) and 16 (40.00%) patients were overweight (BMI≥25 but <30). A total of 11 (27.50%) patients had BMI <25. The mean KCS as well as JOA scores at the time of final follow-up were found to be significantly improved as compared to KCS and JOA scores at the time of presentation and the difference was found to be statistically highly significant (p<0.05). There was a significant reduction in pain as assessed by VAS score. Total 6 (15%) patients developed complication which could be managed conservatively.
Conclusion: TKA in patients with moderate-to-severe OA treated by TKA is associated with significant improvement in functional outcome and acceptable complication rate.
Guía de Animales de Compañía para Dueños Responsables
Authors:   Facultad de Medicina Veterinaria y Zootecnia, Ramírez García Juan Ulises , Arvizu Tovar Laura Olivia ,   Facultad de Medicina Veterinaria y Zootecnia, Soberanis Ramos Orbelin ,   Facultad de Medicina Veterinaria y Zootecnia, Sánchez Zambrano Luisa María ,   Facultad de Medicina Veterinaria y Zootecnia, Téllez Reyes Retana Eduardo Ramón ,   Facultad de Medicina Veterinaria y Zootecnia
Published: June 2023

Lo fundamental de esta obra está basado en el perfil del profesionista médico veterinario y en el conjunto de leyes, reglamentos, normas que tiene que observar en cada una de sus actividades, con el único objetivo de proteger la salud pública; adicional al conocimiento científico y la ética profesional. En México, el conocimiento del marco legal permite al médico veterinario identificar y aplicar sus conocimientos técnicos y científicos, con ética y dentro del marco normativo, lo que impacta en beneficio personal y en la sociedad a la que sirve. La obra ofrece una guía respecto de los trámites y documentos necesarios para establecer una clínica, un hospital o un consultorio médico veterinario. Y para lograr una buena comprensión se divide en una primera parte documental, la cual especifica los trámites; la segunda parte trata de los productos farmacéuticos veterinarios, de acuerdo con su clasificación y prescripción, así como aquellos que están prohibidos o permitidos para la comercialización; y finalmente la tercera parte trata sobre la clasificación de residuos y los procesos a seguir para su desecho.
Medición de los principales impactos económico-urbanos en el Sector Construcción en la Región Centro de México, 2015-2019. Un enfoque espacial con insumo-producto regional
Authors:   Instituto de Investigaciones Económicas, Garduño Maya Karina
Published: June 2023

Esta obra aborda la necesidad de medir los impactos económicos generados en la indus-tria de la construcción, a partir de la puesta en marcha de infraestructura urbana, tomando como caso de estudio a la Región Centro de México.
SalonPro: Discover, Book and Beautify
Authors: Bora Shradha
Published: June 2023

Abstract: In the fast-paced salon industry, effective data management and seamless appointment booking are crucial for maintaining a successful business. This abstract presents the key features and benefits of a comprehensive website-based system designed to streamline data management and appointment booking for salons. The system incorporates a user-friendly appointment booking feature on the website, enabling customers to easily schedule appointments with their preferred stylists or therapists. The website presents an intuitive interface where customers can view available time slots, select desired services, and make bookings in real-time. Additionally, the system can offer supplementary features such as online payment processing, customer reviews and feedback, loyalty programs, and marketing tools. These features empower salons to engage with customers, cultivate loyalty, and attract new clients through targeted promotional campaigns. Implementing this comprehensive data management and appointment booking system website brings numerous advantages for salon owners and customers alike. It optimizes salon operations, improves customer satisfaction, increases revenue, and provides valuable insights for business growth.
Differences in children's empathy and caring behavior across mother happiness cluster types
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Heo Ja-youn , Moon Hyuk-jun
Published: June 2023

Objectives This study aimed to examine the differences in empathy ability and caring behavior of children across the cluster type of mother's happiness. Methods A survey was conducted on 370 mothers with children aged 4 to 5 living in Seoul and Gyeonggi Province, from October to November 2021. Based on the collected data, cluster types were derived through hierarchical cluster analysis and K-means cluster analysis methods, and the analysis was performed by one-way ANOVA. The main research findings are as follows. Results First, four types of happiness were identified: ‘a group for higher happiness’, ‘a group for higher autonomy’, ‘a group for higher personal growth’, and ‘a group for lower happiness’. Second, the children of mothers from the ‘higher happiness group’ and ‘higher autonomy group’ showed higher empathy and caring behavior than those of mothers from the other groups. Lastly, children of mothers of the ‘higher personal growth’ group were not higher in empathy and caring behavior than those of other mother groups. Conclusions The study results imply that the mother's happiness as a caregiver is important for the development of children's empathy and caring behavior, and that an social and policy approach that can enhance mother's happiness is needed for better children’s empathy and caring behavior. This study is to understand the relationship between parent-child finteraction, child's self-regulation, and child's caring behavior in the early childhood.
The influence of insecure adult attachment on depression: The mediating effect of internalized shame and mentalization
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Sangsoon , Kim Songji
Published: June 2023

Objectives The purpose of this study was to verify the mediating effects of internalized shame and mentalization in the relationship between insecure adult attachment (attachment anxiety, attachment avoidance) and depression. Methods For that purpose, 317 adults across the country were surveyed to measure adult attachment, internalized shame, mentalization, depression. SPSS Process Macro was used to analyze the data. Results First, attachment anxiety, attachment avoidance, internalized shame, mentalization, depression all showed significant correlations. Second, The mediating effect of internalized shame and mentalization in the relationship between attachment anxiety, attachment avoidance and depression was significant. Third, The sequential mediating effect of internalized shame and mentalization in the relationship between attachment anxiety and depression was not significant. Fourth, The sequential mediating effect of internalized shame and mentalization in the relationship between attachment avoidance and depression was significant. Conclusions This study confirmed the complete mediating effect of internalized shame and mentalization in the process of attachment anxiety affecting depression, and confirmed the sequential mediating effect of internalized shame and mentalization in the process of attachment avoidance affecting depression.
The Relationship between Adult Attachment and Emotion Dysregulation in College Students: The mediating effects of mentalization and rejection sensitivity
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Bobae , Lee Eunju
Published: June 2023

Objectives This study attempted to verify the mediating role of mentalization and rejection sensitivity in the relationship between adult attachment and emotion dysregulation of college students. Methods To this end, the results were analyzed for 409 college students attending universities nationwide. The research period was conducted as an online survey from August 3 to September 5, 2021, and analyzed through SPSS 28.0 and PROCESS Macro (ver. 3.5). Model 6 was used to verify the mediating effect of mentalization and rejection sensitivity in the relationship between adult attachment and emotion dysregulation, and bootstrapping was performed to verify the significance of the mediating effect. Results There was a significant correlation between adult attachment (attachment anxiety, attachment avoidance), mentalization, rejection sensitivity, and emotion dysregulation. Mentalization showed a complete mediating effect in the relationship between attachment avoidance and emotion dysregulation, and a partial mediating effect was confirmed in the relationship between attachment anxiety and emotion dysregulation. Rejection sensitivity showed a complete mediating effect in the relationship between attachment avoidance and emotion dysregulation, and a partial mediating effect was confirmed in the relationship between attachment anxiety and emotion dysregulation. As a result of verifying the sequential mediating effect of mentalization and rejection sensitivity in the relationship of emotion dysregulation of adult attachment (attachment anxiety, attachment avoidance), attachment avoidance showed a complete mediating effect in emotion dysregulation sequentially through mentalization and rejection sensitivity. Attachment anxiety negatively affected mentalization, but mentalization did not have an influence on rejection sensitivity, so there was no sequential mediating effect to emotion dysregulation. Conclusions The relationship between adult attachment and emotion dysregulation was confirmed for the college student group, and this will give appropriate implications for the intervention of counseling considering the level of mentalization and rejection sensitivity in the unstable college student counseling scene.
Effects of Carbon Dioxide Concentration and Noise Level in Classroom on Attention and Problem Behavior of Elementary School Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Hansol , Park Daechul , Kim Hyunwook
Published: June 2023

Objectives The purpose of this study is to examine changes in carbon dioxide concentration and noise levels in classrooms, and to analyze the effects of these changes on elementary school students' attention and problem behaviors. Methods First, To measure the change of carbon dioxide and noise levels in classrooms, theses levels were measured in general classroom, specific subject classroom, and specific subject classroom with ventilation system operating. Second, to analyze the effect of carbon dioxide and noise levels on students’ attention and problem behavior, situations where both carbon dioxide and noise levels are low (cLnL), only carbon dioxide levels are high (cHnL), and only noise levels are high (cLnH), and both carbon dioxide and noise levels are high (cHnH). Results The carbon dioxide concentration in each classroom ranged from 400 to 1951.8 ppm, and the noise level ranged from 12.6 to 96.6 db(A). As a result of analyzing the effects of carbon dioxide and noise levels on attention and problem behavior, it was resulted that the higher the noise level, the negatively correlated with Work instruction comprehension, Selective attention, and Sustained attention. In addition, problem behaviors occurred the least (3 times) in the cLnL group and the most (31 times) in the cHnH group. Conclusions Carbon dioxide concentration and noise levels in the school exceeded the standard. The learning environment can affect not only students' attention and problem behavior, but also their health. To improve this, physical environment improvement is required.
A Study on the Perceptions of Graduate Students of Education on Cooperative Learning: Based on the metaphorical analysis
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Sihyun , Yim Sujin , Kim Daekwon
Published: June 2023

Objectives Due to the development of technology and rapid social change, there is a need to train talents equipped with core competencies for the future society and to innovate classroom teaching. Cooperative learning is attracting attention as an effective teaching and learning methods that can replace the learning structure of traditional learning methods through many prior studies. This study aims to derive implications for the perception of cooperative learning and class innovation as an adult learner targeting graduate students of education who have experienced cooperative learning. Methods To this end, we tried to examine their perceptions through a questionnaire that asked 50 master's courses to write metaphors and describe specific reasons for selecting metaphors at K University and S University's Graduate School of Education in Seoul. The collected data categorized the answers of each area of open questions into inductive content analysis according to the metaphor category based on metaphor analysis. Results The metaphorical expression of graduate students of education regarding cooperative learning could be categorized into five types: ① responsible activities, ② interactive activities, ③ various activities, ④ challenging but meaningful process, and ⑤ lack of will to cooperate. Conclusions From the questionnaire survey, graduate students of education recognized the cooperative learning as the teaching and learning methods (various activities) that make student accept the perspectives of others through the process of solving tasks (challenging but meaningful process) based on the positive interdependence (‘interactive activities’) by cooperation each other (responsible activities). Therefore, the authors drew the following implications for class innovation. First, the need for interaction between teachers and students, second, practical support, such as the application of various teaching methods in the curriculum of graduate schools of education, are required.
The Effects of Online Havruta Discussion Based AI(Artificial Intelligence) Application Education: Focusing Pre-service Teachers' Creative Teaching Efficacy
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Joung Sunyoung , Jang Sang-Kyun
Published: June 2023

Objectives The purpose of this study was to investigate the effects of online Havruta discussion-based AI application education on pre-service teachers' creative teaching efficacy. Methods For this purpose, 48 college students taking education method and educational engineering courses at K University in Seoul were randomly assigned to either experimental or control group, and eight topics on AI application education were conducted for eight weeks. The experimental group conducted online Havruta discussion activities in AI application education, and the students in the control group conducted a general online teaching method in AI education. Pre- and post-surveys were conducted in the control group and the experimental group, and covariance analysis was performed on the collected data to find out the difference in creative teaching efficacy of pre-service teachers between the two groups. Results It was found that there was a statistically significant difference in creative teaching efficacy between the experiment and control group. The experimental group showed higher scores in creative teaching strategy efficacy and creative thinking efficacy, which are sub-elements of creative teaching efficacy than the control group, which showed statistically significant differences. Conclusions This online Havruta discussion-based AI application education promoted high-quality discussions through continuous questions and answers to pre-service teachers, and improved creative teaching efficacy. This study, which applied the online Havruta discussion activities, is meaningful in that it presented specific ways to promote social interaction in an online educational environment and specific strategies for teachers to effectively apply artificial intelligence education in the authentic educational environment.