bluuebunny/crossref_metadata_2025 huggingface dataset:
Existing and Evolving Therapies for Arteriovenous Fistula and Graft Dysfunction
Authors: Vachharajani Tushar J , Bhargava Vinant , Sequeira Adrian , Meena Priti
Published: July 2024

A functional vascular access (VA) is of paramount importance to patients on hemodialysis therapy. While arteriovenous fistula (AVF) remains the preferred VA, their long-term patency is unpredictable. A dysfunctional VA contributes to a high morbidity rate, an increased susceptibility to major adverse cardiovascular events, recurrent hospitalization, and a poor quality of life. The recent innovations in devices and technologies have significantly expanded our options to create and prolong VA patency. Endovascular devices such as WavelinQ and Ellipsys are recent additions to creating a VA. The endovascular creation of AVF helps reduce the wait time and potentially avoids or reduces the duration of catheter use. The bioengineered graft and immediate access arteriovenous graft offer reasonable alternatives in a select group of patients. There is growing evidence that covered stents and drug-coated balloons offer options to prolong the VA patency. Finally, the role of stem cell therapy in VA is currently being explored. This article presents a comprehensive review of the conventional and current developments in the management of a dysfunctional VA.
Foot-and-mouth disease: prevention and controls.
Authors: Лозовой Д.
Published: July 2024

Своевременная диагностика ящура, изучение выделенных изолятов, срочное изготовление вакцин с использованием новых штаммов и их оперативное применение в неблагополучных зонах позволяют эффективно ликвидировать очаги заболевания.

Timely diagnosis of foot-and-mouth disease, studying the isolates, urgent production of vaccines using new strains, and their prompt use in disease areas allow effective elimination of the disease foci.
When Do Quantum Mechanical Descriptors Help Graph Neural Networks Predict Chemical Properties?
Authors: Li Shih-Cheng , Wu Haoyang , Menon Angiras , Spiekermann Kevin , Li Yi-Pei , Green William
Published: July 2024

Deep graph neural networks are extensively utilized to predict chemical reactivity and molecular properties. However, because of the complexity of chemical space, such models often have difficulty extrapolating beyond the chemistry contained in the training set. Augmented model with quantum mechanical (QM) descriptors is anticipated to improve its generalizability. However, obtaining QM descriptors often requires CPU-intensive computational chemistry calculations. To identify when QM descriptors help graph neural networks predict chemical properties, we conduct a systematic investigation of the impact of atom, bond, and molecular QM descriptors on the performance of directed message passing neural networks (D-MPNNs) for predicting 16 molecular properties. The analysis surveys computational and experimental targets, classification and regression tasks, and varied dataset sizes from several hundred to hundreds of thousands of datapoints. Our results indicate that QM descriptors are mostly beneficial for D-MPNN performance on small datasets, provided that the descriptors correlate well with the targets and can be readily computed with high accuracy. Otherwise, using QM descriptors can add cost without benefit or even introduce unwanted noise that can degrade model performance. Strategic integration of QM descriptors with D-MPNN unlocks potential for physics-informed, data-efficient modeling with some interpretability that can streamline de novo drug and material designs. To facilitate the use of QM descriptors in machine learning workflows for chemistry, we provide a set of guidelines regarding when and how to best leverage QM descriptors, a high-throughput workflow to compute them, and an enhancement to Chemprop, a widely adopted open-source D-MPNN implementation for chemical property prediction.
Digestion-Free Absolute Quantification of Conjugated Payload from ADCs Using Middle-Down Fragmentation Mass Spectrometry
Authors: Yuan Jiaqi , Tan Hui Yin , Huang Yue , Rosenbaum Anton
Published: July 2024

Antibody-drug conjugate (ADC) is a therapeutic modality that aims to improve payload delivery specificity and to reduce systemic toxicity. Considering the complex structure of ADCs, various bioanalytical methods by liquid chromatography coupled with mass spectrometry (LC-MS) and ligand binding assay (LBA) as well as hybrid LBA-LC-MS approaches have been established for ADC characterization and quantification. LCMS-based assays enable Drug-Antibody Ratio (DAR) sensitive quantification of conjugated payload. For quantitative DAR-sensitive assessment by LC-MS/MS, typically the conjugated payload is enzymatically liberated and quantified. Despite recent advances in ADC bioanalytical methods, the DAR-sensitive quantification of non-cleavable linker ADCs by LC-MS/MS remains challenging. Thus, we developed a novel middle down Collision-Induced Dissociation fragmentation approach for absolute quantification of conjugated payload for 4 different ADCs in biological matrix with minimum sample preparation. The results of these four examples demonstrate that ADCs with different linker-payload structures can be quantified, including a non-cleavable linker ADC trastuzumab emtansine. It also shows that the assay sensitivity is comparable to conventional ADC quantification method by linker-payload cleavage using enzyme, while assay dynamic range depends on factors including payload ionization and fragmentation efficiency, DAR and its distribution, and species abundance. By demonstrating absolute quantification of both cleavable and non-cleavable linker ADCs, this novel middle down intact ADC approach demonstrates its potential application in bioanalysis and analytical characterization, especially for early discovery where high-throughput screening is required as the new approach saves time and resources by not requiring enzymatic digestion for cleavable ADCs or development of anti-payload antibodies for non-cleavable linker ADCs.
NQO1-responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell-targeted Migrastatic
Authors: Kagho Mervic D. , Schmidt Katharina , Lambert Christopher , Jia Lili , Rottner Klemens , Stadler Marc , Stradal Theresia , Klahn Philipp
Published: July 2024

Migrastatic drugs targeting cell motility and thereby suppress invasiveness of solid cancer cells, including their ability to metastasize and establish secondary tumors, are of high interest and have the potential to bring about a paradigm shift in the treatment of solid cancer. Cytochalasans, such as cytochalasin B, are known to disrupt cytoskeletal dynamics by inhibiting actin polymerization and have attracted considerable attention as potential migrastatics over the last decades, but are limited by selectivity issues so far. We herein report on the design, synthesis and evaluation of a bioresponsive prodrug BQTML-CB cleavable by the quinone-oxidoreductase NQO1, discussed as therapeutic target for the treatment of cancer.
Rapid Synthesis of Phase-Engineered Tungsten Carbide Electrocatalysts via Flash Joule Heating for High-Current-Density Hydrogen Evolution
Authors: Mashhadian Amirarsalan , Wu Shiwen , Hao Yun , Mosadegh Mahdi , Cho Kyeongjae , Minary-Jolandan Majid , Xiong Guoping
Published: July 2024

Fabricating durable and high-performance electrocatalysts operating at high current densities for industrial acidic hydrogen evolution remains a daunting challenge. Tailoring the phase composition of electrocatalysts is a promising strategy to harness synergistic effects and improve charge transfer, thereby optimizing their performance. This work presents a fast, green method based on flash joule heating (FJH) to synthesize phase-engineered tungsten carbide electrocatalysts for the acidic hydrogen evolution reaction (HER) at high current densities. Tungsten carbide electrodes with varying FJH treatment durations (3, 10, 30, and 60 seconds) are fabricated to fine-tune the mixture of tungsten monocarbide (WC) and tungsten semicarbide (W2C) phases. Results show that samples with a 30-second treatment (TC-3) exhibit an optimal balance between these phases, leading to a low overpotential of 387 mV at a high current density of 4 A/cm2. Notably, the TC-3 electrocatalysts remain stable for over 6 days at 4 A/cm2 due to their controlled phases and excellent corrosion-resistant properties. This work highlights a new method to fabricate cost-effective, high-performance tungsten carbide electrocatalysts with well-controlled phase compositions.
Ab initio electronic absorption spectra of para-nitroaniline in different solvents: intramolecular charge transfer effects
Authors: Maximo-Canadas Matheus , Modesto-Costa Lucas , Borges Jr. Itamar
Published: July 2024

IIntramolecular charge transfer (ICT) effects of para–nitroaniline (pNA) in eight solvents (cyclohexane, toluene, acetic acid, dichloroethane, acetone, acetonitrile, dimethylsulfoxide, and water) are investigated extensively. The second-order algebraic diagrammatic construction, ADC(2), ab initio wave function is employed with the COSMO implicit and discrete multiscale solvation methods. We found a decreasing amine group torsion angle with increased solvent polarity and a linear correlation between the polarity and ADC(2) transition energies. The first absorption band involves π→π* transitions with ICT from the amine and the benzene ring to the nitro group, increased by 4 -11% for different solvation models of water compared to the vacuum. A second band of pNA is characterized for the first time. This band is primarily a local excitation (LE) on the nitro group, including some ICT from the amine group to the benzene ring that decreases with the solvent polarity. For cyclohexane, the COSMO implicit solvent model shows the best agreement with the experiment, while the explicit model has the best agreement for water.
Dyeing to Know: Optimizing Solvents for Nile Red Fluorescence in Microplastics Analysis
Authors: Ho Derek , Masura Julie
Published: July 2024

With the escalation of microplastic (MP) pollution and the laborious nature of existing MP identification methods, new approaches for large-scale sampling of MPs in the environment are necessary. A promising solution lies in the fluorescence staining of Nile Red (NR), whose fluorescence is polarity-dependent, offering the potential for classification based on fluorescence. However, the choice of carrier solvents to dissolve NR remains unstandardized, and methods to represent and differentiate the fluorescent behavior of MPs are lacking. To address this gap, we conducted tests on eight NR-carrier solvents (n-hexane, chloroform, acetone, methanol, ethanol, acetone/hexane, acetone/ethanol, and acetone/water) applied to ten different types of MPs (HDPE, LDPE, PP, EPS, PS, PC, ABS, PVC, PET, and PA). We compared their fluorescence behavior (fluorescence intensity and Stokes shift), evaluated their effects on polymer degradation, and assessed the ability of different potential polarity measures and color spaces to accurately reflect Stokes shift for MP classification. Furthermore, Fenton oxidation was found to quench the fluorescence of natural organic matter (e.g., eggshells, fingernails, wood, and cotton), with minimal changes observed in NR-stained MPs. Our findings identified acetone/water [25%] as the best compromise, effectively mitigating the adverse effects of acetone while maintaining strong fluorescence behavior suitable for classification.
First-principles study of structural, electronic, optical, and thermoelectric properties of BaTmSe2 (TM = Fe, Co, and Ni) for optoelectronic devices
Authors: Zia Bukhari Sayada Ayesha , Ismail Khawar , Aslam Muhammad Anis , Khan Adnan Ali , Abbas Muhammad Sohail , Ahmad Rashid
Published: July 2024

In this study, the structural, electrical, optical, and thermoelectric properties of BaTMSe2 (TM = Fe, Co, Ni) are investigated using DFT within the Wien2k software. For electronic band structure and thermal characteristics, the PBE + GGA approximation method is employed, while the density of state analysis is used to ascertain the contributions and polarization of electronic states. The compounds exhibit unsymmetrical behavior of majority charge carriers in spin up and down, and Fe, Co, and Ni atoms contribute most to TDOS and PDOS via hybridization with Se and Ba atoms. The materials show semiconductor characteristics, with BaFeSe2 having the largest peak on the optical properties graph. BaXSe2 has a refractive index higher than, and BaFeSe2 and BaCoSe2 have separate peaks in their extinction coefficients within the visible spectrum. The optical properties graph shows that BaFeSe2 has the highest peak at 1eV and that all compounds exhibit a comparable pattern as they move towards greater energies. The negative value in the real part expresses that the electromagnetic radiation is partially reflected from the surface of the material and shows semiconductor behaviour. The extinction coefficient of BaFeSe2 and BaCoSe2 have sharp peaks in the visible energy range. The refractive index of BaXSe2 (X = Fe, Co, Ni) is higher than 1 due to the interplay of electrons with the substance slowing down photons. The highest peak of the refractive index is at 0.1 eV, 0.2 eV, and 0.3 eV for BaFeSe2, BaCoSe2, and BaNiSe2, respectively. The trend gradually declines in higher energies before becoming constant after 4 eV. Additionally in this article, thermal properties of BaTMSe2 (TM=Fe, Co, Ni) like the Seebeck coefficient, thermal conductivity, magnetic susceptivity, figure of merit, and specific heat capacity are investigated, and it significantly enhances the properties of compounds having a rapid response to charge mobility.
Unlocking Inclusive Growth and Sustainable Development in Nigeria: A Roadmap Through Challenges and Opportunities
Authors: Aluko O. A. , Odewale A. T. , Taiwo K. , Adefeso H.
Published: July 2024

Purpose: This paper aimed to explore the concept of inclusive growth within Nigeria's socio-economic framework, particularly in light of the Nigeria Agenda 2050 (NA2050), a strategic policy initiative. It seeks to understand Nigeria's multifaceted challenges and opportunities in achieving inclusive growth.
Design/Methodology/Approach: The study reviewed secondary data sources including, reports from various agencies and institutions, and government data. It utilised thematic analysis to dissect and present insights into Nigeria's developmental trajectory as outlined by NA2050.
Findings: Despite significant economic strides, Nigeria struggles with socio-economic disparities, marked by high unemployment, rising inflation, and infrastructural deficits. The NA2050 is a crucial framework advocating for robust governance, macroeconomic stability, economic diversification, and human capital development to overcome these challenges.
Practical Implications: The study highlighted the essential roles of technological advancement and financial inclusion as key drivers of sustainable development and economic resilience in Nigeria. It calls for a multi-stakeholder approach to implement NA2050's strategies effectively, enhancing transparency in the oil sector, prioritising human capital development, and fostering private sector-led growth.
Social Implications: This research emphasised the need for inclusive growth that benefits all societal layers in Nigeria, addressing the persistent socio-economic gaps that hinder equitable development and social cohesion.
Originality and Value: The paper contributes to the discourse on inclusive growth by providing a pragmatic roadmap for Nigeria’s socio-economic revitalisation, offering a detailed analysis of the strategies embedded in the NA2050 and their potential impact on the nation's future.
NGHIÊN CỨU MỐI QUAN HỆ GIỮA HOẠT ĐỘNG LOGISTICS VÀ HIỆU QUẢ KINH DOANH CỦA CÁC DOANH NGHIỆP DỆT MAY KHU VỰC BÌNH TRỊ THIÊN
Authors: Thanh Lê Thị Phương , Thảo Lê Thị Phương , Hoàng Tống Viết Bảo
Published: July 2024

Mục đích của bài viết nhằm xác định mối quan hệ giữa các yếu tố hoạt động logistics và hiệu quả kinh doanh của doanh nghiệp dệt may trên khu vực Bình Trị Thiên. Nghiên cứu đã tổng hợp kết quả khảo sát 212 doanh nghiệp dệt may tại ba tỉnh và dữ liệu thu thập được phân tích bằng phương pháp PLS - SEM. Kết quả đã thể hiện có 5 yếu tố cấu thành hoạt động logistics đó là: logistics nội bộ, logistics đầu vào, logistics đầu ra, logistics hỗ trợ và chi phí logistics. Nghiên cứu cũng đã xây dựng mô hình dự đoán ảnh hưởng của hoạt động logistics đến hiệu quả kinh doanh của doanh nghiệp dệt may là thuận chiều (với hệ số chuẩn hóa là 0,524). Ngoài ra kết quả cũng chỉ ra nếu hoạt động logistics dưới tác động của dịch Covid 19 thì lại ảnh hưởng ngược chiều đến hiệu quả kinh doanh của doanh nghiệp dệt may (với hệ số chuẩn hóa là -0,069). Thông qua đó, bài viết đã chỉ ra các doanh nghiệp dệt may muốn nâng cao hiệu quả kinh doanh cần sử dụng hợp lý chi phí logistics và nâng cao chất lượng các hoạt động logistics đầu vào, đầu ra, nội bộ, hỗ trợ trong thời gian tới.
ẢNH HƯỞNG CỦA TRUYỀN MIỆNG ĐIỆN TỬ (EWOM) ĐẾN THÁI ĐỘ CỦA DU KHÁCH ĐỐI VỚI ĐIỂM ĐẾN DU LỊCH HUẾ
Authors: Hương Nguyễn Thị Lệ , Hoàn Phan Thanh
Published: July 2024

Nghiên cứu này nhằm mục đích phân tích ảnh hưởng của truyền miệng điện tử (eWOM) đến thái độ của du khách đối với điểm đến du lịch Huế. Từ mô hình nghiên cứu đề xuất, 3 nhân tố được xác lập là eWOM, hình ảnh điểm đến (HADD) và thái độ điểm đến (TDDD) với 17 biến đo lường. Kết quả phân tích SEM cho thấy, eWOM ảnh hưởng trực tiếp đến sự hình thành HADD của những người tìm kiếm thông tin qua internet và đến thái độ của du khách đối với điểm đến; HADD là nhân tố trung gian và có vai trò quan trọng đối với TDDD. Trong mối quan hệ của các nhân tố, eWOM chính là nguồn gốc để thúc đẩy sự tích cực trong nhận thức của du khách về HADD và TDDD. Từ đó, các khuyến nghị tập trung vào việc hoàn thiện các yếu tố của điểm đến để tạo nên eWOM tích cực; tăng cường sự tiếp cận người viết và người đọc đối với eWOM; và chủ động khai thác và kiểm soát nguồn thông tin eWOM của các điểm đến.
TÀI SẢN THƯƠNG HIỆU BÁO ĐIỆN TỬ VIỆT NAM: TỪ HÀI LÒNG ĐẾN TRUNG THÀNH THƯƠNG HIỆU
Authors: Quân Nguyễn Hồng , Linh Nguyễn Thuỳ , Ngọc Tống Bảo , Linh Nguyễn Dương Thùy , Nguyệt Hoàng Thị Minh
Published: July 2024

Nghiên cứu phân tích mối quan hệ phức tạp giữa các yếu tố Nhận thức thương hiệu, Niềm tin thương hiệu, Giá trị cảm nhận, Hài lòng thương hiệu và Trung thành thương hiệu trong bối cảnh thương hiệu báo điện tử ở Việt Nam dựa trên lý thuyết về mô hình tài sản thương hiệu CBBE (Customer-based Brand Equity). Dữ liệu điều tra được thu thập bằng hình thức trực tiếp và trực tuyến đối với 303 độc giả số của các trang báo điện tử phố biến nhất hiện nay như: VnExpress, Dân trí, VietNamNet, Tuổi Trẻ và Thanh Niên. Dữ liệu thu thập được làm sạch, xử lý và tiến hành phân tích mô hình cấu trúc PLS-SEM bằng công cụ SmartPLS. Kết quả nghiên cứu đã cung cấp một cơ sở thực chứng về tác động tích cực của các nhân tố ảnh hưởng đến sự trung thành thương hiệu và vai trò trung gian của sự hài lòng thương hiệu trong bối cảnh thương hiệu báo điện tử ở Việt Nam, từ đó đóng góp vào cơ sở lý thuyết về mô hình tài sản thương hiệu.
Jóvenes indígenas y resignificaciones identitarias en la educación superior intercultural en México
Authors: Mira Tapia Alejandro
Published: July 2024

Este artículo aborda los procesos de resignificación identitaria de las juventudes indígenas en la educación superior intercultural. El objetivo es evidenciar cómo detrás del reforzamiento de las identidades étnicas de los agentes sociales que participan en este campo educativo, necesariamente están implicados procesos de agencia y subjetivación que revierten las posiciones desvalorizadas que les han sido asignadas externamente. Para ello, se comparten testimonios atravesados por el racismo que son proporcionados por jóvenes ñöñho quienes se escolarizan en una universidad intercultural ubicada en su propia localidad.
Escola sem Partido e as discussões de gênero e sexualidade
Authors: Silveira Bonacazata Santos Marina , Miesse Maria Carolina , De Carvalho Fabiana Aparecida , Cordeiro de Queiroz Leonardo , Matias de Souza Vânia de Fátima
Published: July 2024

A investigação objetiva analisar o impacto do conservadorismo do Movimento Escola Sem Partido (MESP) na abordagem das temáticas de gênero e sexualidade dentro da política curricular da educação básica brasileira. Ancorada em análise documental, a pesquisa discute a conjuntura histórica e educacional e a conformação das ideologias do movimento nas políticas educacionais, em especial, na Base Nacional Comum Curricular (BNCC). Assim, o texto discorre sobre a história do programa, bem como aborda o combate às questões de gênero pautado em uma postura conservadora e sua relação com a aprovação da BNCC.
“Fazia uma dança que nem sabia fazer”: arte, docência e pesquisa com crianças
Authors: Silva Andréa Fraga da , Prado Patrícia Dias
Published: July 2024

A partir da investigação de processos de criação em dança com crianças da Escola Municipal de Iniciação Artística de São Paulo (EMIA), o artigo apresenta modos de participação das crianças, validando suas linguagens e assumindo a improvisação, o caos e a deriva como procedimentos investigativos, artísticos e pedagógicos. Amparadas nos Estudos Sociais da Infância, a escuta e diálogo com as crianças deixaram emergir suas perspectivas sobre seus processos investigativos e experiências estéticas, presentes em suas falas e gestualidades, contribuindo assim com a construção da docência e pesquisa em dança com crianças.
A trama narrativa urdida no cotidiano da docência
Authors: Abrahão Maria Helena Menna Barreto , Cunha Maria Amália de Almeida
Published: July 2024

Este Dossiê busca refletir acerca da presença da pesquisa narrativa na vivência do ordinário da docência, tendo em vista justamente entendermos que, ao trabalharmos com formação de professores, operamos com narrativas reflexionadas de si, na dimensão pessoal estendida ao social do fazer docente. Nossas lembranças, nossa memória, nossa capacidade de relatabilidade do mundo vivido transformam-se em disposições no espaço da docência, voltadas para a transmutabilidade da palavra, da ação, da escrita, do gesto. A palavra, a ação, a escrita, o gesto expressam-se em narrativas de si, construtoras do sujeito da docência, o sujeito que, ao se narrar reflexivamente, narra-se para outrem, dele diferente. Esse é, pois, um movimento que se dá na alteridade exigente de um eu e um outro, em diálogo. Assim, é mediante a trama narrativa produzida em alteridade que se constrói uma identidade narrativa gestada na dialética do si mesmo, constitutivo da identidade pessoal e o outro, instituinte da alteridade do si. Essa trama entrelaça, em uma intriga discursiva, elementos concordantes/discordantes que dão sentido ao vivido, para o narrador e para o outro, ao urdir os fatos e relacioná-los ao contexto sociopolítico, cultural e profissional vivenciado. Essa trama também emerge mediante um constructo tridimensional, em que passado, presente e futuro se vinculam, no sentido de que o caráter temporal da experiência do sujeito, tanto na perspectiva pessoal, quanto social, igualmente articula-se pela narrativa autobiográfica. Com esse entendimento, este Dossiê busca refletir sobre a polissemia da trama narrativa tecida no cotidiano da docência, urdida pelos sujeitos no tempo quando, por meio de recordações-referências, pensam sua vida mediante um rito de passagem, e sobre memoriais de formação e acadêmicos, para aqueles sujeitos que concebem e planejam suas práticas profissionais mobilizando as diferentes formas de relatar e narrar o mundo que os habita.
Pilot Study of Behavioral Attitudes of Youth towards People with Skin Imperfections
Authors: Zorina S. V. ,   Samara National Research University
Published: July 2024

The article presents the study of the correlation between an explicit attitude and an implicit tendency of nearing/distancing from people with skin imperfections. The subjects did a task on a computer where they had either to place nearer the photos of people with dermatological facial problems (capillary angiodisplasya, pitted acne scars, acne) or to distance them, fixing the time of the response delay. The study has shown no difference between behavioral tendency of nearing and distancing towards people with dermatological facial problems and without them. The subjects showed readiness to start personal relationships and positively assessed the social status of this kind of people. The study has revealed no correlation between the indices of the implicit task of nearing/distancing and those of direct questionnaire methods. The subjects need more time to show behavioral tendency of both nearing and distancing towards people with skin imperfections.
The Effectiveness of a Comprehensive threat Mitigation Framework in NETWORKING: A Multi-Layered Approach to Cyber Security
Authors: Balisane Hewa ,   Business School, The University of Law, United Kingdom, Egho-Promise Ehigiator , Lyada Emmanuel , Aina Folayo , Sangodoyin Abimbola , Kure Halima ,   ICT department, City of Oxford College and University Centre,  United Kingdom,   Learning Content Developer, ISBAT University, Kampala, Uganda,   Department of Computing, School of Engineering and Computing University of Central Lancashire, United Kingdom,   School of Computer Science, University of Lincoln, United Kingdom,   Department of Engineering & Computing University of East London
Published: July 2024

The rapidly evolving landscape of cyber threats necessitates robust and adaptable strategies to safeguard networking. This study explores the development and evaluation of a comprehensive framework for threat mitigation, integrating advanced methodologies from cybersecurity, risk management, and threat intelligence. Leveraging a mixed-methods approach, including surveys and secondary data analysis, the research assesses current practices and identifies critical gaps in existing frameworks. The proposed multi-layered defense mechanism incorporates proactive and reactive measures, aligning real-time threat intelligence with sophisticated incident response strategies. Key components such as anomaly detection systems, employee training, and continuous security audits are highlighted as essential elements of the framework. Through extensive validation, including empirical tests and case studies, the framework demonstrates its efficacy in enhancing organizational resilience against complex cyber threats. The findings provide valuable insights into the practical application of integrated cybersecurity measures, offering a scalable and flexible solution tailored to the dynamic nature of digital security challenges. This study addresses the critical need for an adaptable and holistic approach to threat mitigation, contributing to the field of cybersecurity with actionable strategies for managing and mitigating digital threats
Tourism activities in the frontline areas of Sumy region: problems, opportunities and prospects
Authors: Kornus Olesia , Venherska Natalia , Reimann Mart , Kornus Anatolii , Patsiuk Viktoriia
Published: July 2024

The Sumy region has great and significant tourism potential. Before the Russo-Ukrainian War, the region had 3,465 historical and cultural monuments, including 367 architectural and urban planning monuments (five of them of national importance). Before the war, the tourism sector was developing steadily, with new types of tourism services and the formation of tourism clusters. However, Russia's Invasion of Ukraine resulted in a significant decrease in tax revenues, which has a negative impact on tourism. The purpose of this paper is to study the peculiarities and future prospects of tourism development in the Sumy region during the war, based on data from a sociological survey conducted in five Ukrainian frontline regions in the framework of the Estonian-Ukrainian research project "Development of Ukrainian frontline communities and tourism business during the war and future strategy", which was supported by the Estonian Research Agency.

The sociological survey was conducted online and included 25 closed and open-ended questions. Survey results were processed using Microsoft Excel 2010 and SPSS Statistics V21.0. A total of 29 respondents (20.1%) from the Sumy region participated in the sociological survey, 69% of whom live in urban areas and 31% in rural areas. Analysis of the areas of activity of the tourism respondents from the Sumy region revealed that urban respondents were more representative of tourism businesses (tour operators, travel agents, sole proprietors, etc.), while rural respondents were predominantly representatives of tourist attractions (museums, educational and recreational facilities, etc.). Responses to the following questions were analyzed: pre-war tourism activities, wartime tourism activities, changes in tourism, prospects for tourism development, threats and opportunities for tourism development, problems in the tourism sector, prospects for tourism development, and advantages in cluster cooperation.
The Effects of TMR® Fab 6 on Hamstring Flexibility in Healthy Subjects; An Exploratory Observational Investigation
Authors: Patterson Richard D. , Zettlemoyer Alexander , Plackowski Mary , Baker Russell , Cheatham Scott W. , Nasypany Alan
Published: July 2024

Background

Stretching programs are designed to improve hamstring flexibility by attempting to mechanically increase the length of the target tissue. However, other manual treatment approaches such as those utilized in Total Motion Release (TMR®), could be beneficial by identifying body asymmetries to assess and treat soft tissue impairments leading to diminished extensibility.

Purpose

The purpose of this study was to determine the effectiveness of the TMR® Fab 6 assessment and treatment to increase hamstring flexibility in healthy participants following one session of TMR®.

Study Design

Observational Cohort study

Methods

A convenience sample of 20 healthy participants (10 males, 10 females) were recruited from three institutions. Following collection of demographic information and a brief medical history, each participant performed a five minute warm-up on the stationary bike at a moderate intensity (80-90 RPMs) followed immediately by the bilateral performance of the Active Knee Extension Test (AKET) and Passive Straight Leg Raise (PSLR) to assess hamstring muscle length. Participants were randomly placed in the TMR® or control group. The TMR® group completed the “Fab 6” evaluation and treatment, while the control group performed one repetition of standing active hip flexion every 30-seconds for 15-minutes with both knees in full extension. Upon completion of treatment, control and TMR® groups were immediately re-evaluated on the AKET and the PSLR in the same order and fashion as baseline testing. Participants were asked to return in 24-hours for the same objective measurements as previously described.

Results

A significant time by group interaction was identified across all variables (p ≤ 0.001) for AKET and PSLR except the PSLR preferred leg from post-treatment to 24hr follow-up. The most significant increase in the AKET occurred in the TMR® group between baseline and post-treatment of the non-preferred leg (12.15°±2.94) when compared to the control group (7.15°±1.56).

Conclusion

The results of the study suggest that implementing a regionally interdependent treatment approach like TMR® results in significant improvements in hamstring extensibility and hip ROM compared to the control group.

Level of evidence

3
Enhancing Return to Alpine Skiing: Integrating Perceptual-Motor-Cognitive Considerations in Testing and Progressions: A Clinical Commentary
Authors: Smith Conor , Grooms Dustin R. , Bradley Helen
Published: July 2024

Alpine skiing poses significant risks for anterior cruciate ligament (ACL) injury at both recreational and professional levels, which is compounded by high rates of re-injury. Despite the existence of return to sport (RTS) and return to snow protocols, the frequency of ACL re-injury has not been mitigated, raising doubts about protocol effectiveness. Current RTS protocols primarily focus on biomechanical and neuromuscular factors in isolation, neglecting the important perceptual-motor-cognitive changes associated with ACL injuries and the high cognitive demands of skiing. The purpose of this clinical commentary is to address the perceptual-motor-cognitive demands specific to alpine skiing, evaluate RTS testing for skiers, and propose updated standards for testing and return to snow progressions that incorporate these considerations.

Level of Evidence

5
An systemic overview of pharmacognostical and therapeutical herbal application of gymnema sylvestre
Authors: Bhavithra V.
Published: July 2024

Gymnema sylvestre, commonly known as Gurmar and belonging to the family Asclepiadaceae, is widely distributed in India, Malaysia, Sri Lanka, Australia, Indonesia, Japan, Vietnam, tropical Africa, and the southwestern region of the Republic of China. The plant G. sylvestre is traditionally used as a sugar destroyer in glycosuria and other urinary diseases. The drug is also used in the composition of Ayurvedic preparations such as Ayaskri, Varunadi kasaya, Varunadighrtam, and Mahakalyanakaghrtam. The present review focuses on the reports available in various literatures. The various chemical constituents isolated include saponins, carbohydrates, anthraquinone derivatives, flavones, flavonoids, formic acid, resins, phytin, etc. The chief constituents are saponins like gymnemic acids, gymnemasaponins, gymnemasides, and gymnemagenin. Gymnema sylvestre is found in capsule, tablet, powder, and tea powder forms. A tablet containing 200-400mg of gymnemic acid is used as a supplement for diabetes and to promote healthy pancreatic function. A 100mg capsule helps maintain blood sugar levels in the normal range and reduce inflammation. Gymnema sylvestre helps to fight sugar cravings and neutralize cravings for sweets.
VULNERABILITY, SUFFERING AND THE LAW UNDER THE EARTHQUAKE
Authors: Uygur Gülriz
Published: July 2024

This paper focuses on the intersection of vulnerability, suffering, and the law in the context of the February 2023 earthquakes in Turkey. The research critically examines the state's responsibility in addressing the vulnerabilities exacerbated by natural disasters. The paper argues that state institutions, by failing to act on prior knowledge and warnings about the earthquakes, displayed a form of culpable ignorance that intensified public vulnerability and suffering. The author draws upon Fineman's vulnerability theory and Fricker's concept of ignorance, emphasizing the importance of acknowledging and responding to inherent human vulnerabilities and societal inequalities in legal and governmental frameworks. The lack of institutional resilience and effective response in the wake of the disaster highlights the need for law and policies grounded in the reality of human vulnerability. The author also explores the role of solidarity in crisis management, suggesting that community efforts can somewhat mitigate the failures of state institutions. The article asserts that legal reforms and international recognition of state responsibility in disaster management are crucial for addressing structural inequalities and improving resilience against future disasters.
Modeling and Behavior Rehearsal to Improve Communication Skills in Adolescent with Language Disorder
Authors: Kurniandini Priskila , Yoenanto Nono Hery
Published: July 2024

Background: Adolescents with language disorder have significant language difficulties in many situations and impact their communication skills. Communication difficulties experienced by adolescents with language disorders can increase the risk of feeling anxious in social situations and having fewer peer relations. Therefore, interventions are needed that can optimize communication skills. Objective: The aim of this research is to find out whether modeling and behavior rehearsal can improve communication skills in adolescent with language disorder. Method: This research is a quantitative research that uses single subject ABA design. The participant is a 14-year-old girl with language disorder. There are 4 skills that are taught & observed, such as giving comments, asking relevant questions, asking the other person's opinion, and paying attention to the other person's attitude while speaking. Results: All communication skills is increasing, including ask the other person's opinion and provide comments that match with the topic. Conclusion: This proves that modeling and behavior rehearsal are effective in improving adolescent's communication skills with language disorder.AbstrakLatar Belakang: Remaja dengan language disorder memiliki hambatan yang signifikan dalam berbahasa di berbagai situasi dan itu berdampak pada kemampuan komunikasi. Kesulitan berkomunikasi yang dialami remaja dengan language disorder dapat meningkatkan risiko merasa cemas dalam situasi sosial dan memiliki sedikit relasi teman sebaya. Karena itu, dibutuhkan intervensi yang bertujuan untuk mengoptimalkan kemampuan komunikasi saat berinteraksi sosial, seperti bertanya dan memberi komentar. Tujuan: Tujuan penelitian ini adalah untuk mengetahui apakah penerapan teknik modeling & behavior rehearsal dapat meningkatkan kemampuan komunikasi pada remaja yang mengalami language disorder. Metode: Penelitian kuantitatif dengan desain single subject research ABA. Partisipan merupakan remaja perempuan berusia 14 tahun dengan language disorder. 4 target perilaku yang diobservasi yaitu memberi komentar, bertanya hal yang relevan, menanyakan pendapat lawan bicara, dan memperhatikan sikap lawan bicara saat berbicara. Hasil: Adanya peningkatan pada kemampuan menanyakan pendapat lawan bicara dan memberikan komentar yang sesuai topik pembicaraan. Simpulan: Teknik modeling dan behavior rehearsal efektif meningkatkan kemampuan komunikasi remaja dengan language disorder.
Flourishing: Development of a Higher-Level Uses Well-Being Scale and Concept in Positive Psychology
Authors: Nur'aini Nadja Alfin , Mulyana Olievia Prabandini
Published: July 2024

Background: Flourishing is the highest level of well-being in positive psychology. Flourishing individuals have high levels of well-being based on hedonic and eudaimonic well-being perspectives. Flourishing is a developing concept that has yet to be widely studied in positive psychology.
Objective: This literature review aims to trace the development of theoretical concepts and scales that can be used to research the flourishing variable further.
Methods: This research uses a literature review, which involves searching reputable journals for articles related to the concept and scale of flourishing.
Results: The PERMA concept introduced by Seligman is the primary literature that forms the foundation for examining flourishing by combining two theories. This PERMA concept states that flourishing in individuals can be measured by five aspects: positive emotions, engagement, positive relationships, meaningfulness, and individual achievement.
Conclusion: Other researchers then developed the PERMA concept as a reference for creating a flourishing scale.
 
Keywords: Flourishing, well-being, theory, scale, literature review
Legal Support for the Digitalization of the Financial Sector in the Context of Achieving the National Goals of Russia's Economic Development
Authors: Molchanova N.P. ,   Lomonosov Moscow State University Moscow, Russia
Published: July 2024

The subject of the study is the current state of digitalization of the financial sector in the Russian Federation. The purpose of the work is to establish prospects for the development of the regulatory framework for the digitalization of the financial sector in conjunction with activities to ensure the achievement of national economic development goals of the country. The article reveals the debatable nature of the conceptual apparatus reflecting the digital transformation of the economy, characterizes various approaches to the meaningful content of the terminology of digitalization of the financial sector. Based on information sources, the progressive nature of the increase in spending on the development of the digital economy has been determined. The analysis of the degree of digitalization of the financial sector is carried out. The positive dynamics of Russian financial sector organizations switching to the use of software innovations, digital data protection technologies and encryption tools has been established. The priorities of digitalization development in the context of achieving the national goals of economic development of Russia are determined. The urgency of the need to create a multidisciplinary legal framework as a reliable basis for continuing the systemic digital transformation of the financial sector has been confirmed. The regulatory documents in force and in the process of public discussion are considered, intended for the legal regulation of the digitalization process in the financial sector of the economy. The directions of improving the work on the legal support of the financial sector are substantiated: data protection, the introduction of the digital ruble, SupTech, RegTech technologies, etc. Conclusions are drawn on the expediency of intensifying research in order to accumulate substantive information for the development of regulatory tools and operational decision-making in the field of legal regulation of financial sector institutions in conjunction with activities to achieve national goals of economic development of the Russian Federation.
The Psychological Well-being of Chinese University Students Under State Bursary
Authors: Yan Wenjuan , Liu Yaoping , Anyanwu Clinton Chidiebere , Siripala Wannaporn , Anwar Khoirul , Santoso Rahmat Agus
Published: July 2024

The purpose of this research is to identify, assess and provide solutions to the psychological challenges faced by university students obtaining state bursaries. The research methodology employed in this study is a mixed-methods design. This study took a two-pronged approach, presenting a questionnaire to 360 bursary-receiving university students and completing semi-structured interviews with a chosen group of ten people at Guangxi Liuzhou University. Utilizing purposive sampling, semi-structured interviews were executed with a select cohort of two financial aid personnel, two counselors, and six bursary recipients, facilitating a comprehensive comprehension of the prevailing circumstances. The data collection tools included Internet questionnaires and in-person interviews. The acquired data was then thoroughly examined utilizing statistical methods such as frequency distribution, percentage computation, and analysis of variance (ANOVA). The investigation revealed that students' psychological difficulties are consistent with the six-factor model's flaws and have multiple causes. The study suggests strategies to address these challenges, such as improving students' psychological well-being education and encouraging self-acceptance, personal growth, autonomy and interpersonal interactions.
N.F. FEDOROV’S ETHICS OF COMMON CAUSE AND ETHICS OF NONVIOLENCE
Authors: Gacheva Anastasiya G. ,   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences,   The Moscow School of Social and Economic Sciences,   Fyodorov’s Library no. 180 OKC of the Southern Administrative District of Moscow
Published: July 2024

The article considers the complex of religious and philosophical ideas of N.F. Fedorov, a Russian thinker, who affirmed the ideal of man’s cooperation with God in the transformation of the world, who put forward the idea of history as a “work of salvation”. It is shown that Fedorov’s philosophy of resurrection and regulation is based on the principle of matching goals and means and relies on a subject-subject approach to the world and man, puts Christ’s commandment about love as the basis of social interaction and in that sense is related to the ethics of nonviolence, appealing to the highest principle in man. In the context of comparing the ethics of the common cause and the ethics of nonviolence, as well as the dispute between N.F. Fedorov and L.N. Tolstoy is considered. It is revealed that the philosopher, arguing with the writer, seeks to put the principle of nonviolence in a strong position, combining it with an ideal of active Christianity, overcoming division and fratricide through the return of life to all victims of history. It is also revealed that the main divide between the ethics of the common cause and the ethics of nonviolence runs along the line of faith/disbelief in the possibility of overcoming evil and death altogether. Fedorov’s approach, which opens up the prospect for moving from non-resistance to evil by violence toward overcoming death and discord as inevitable causes and equally inevitable consequences of violence, frees the ideal of nonviolence from internal contradictions and inevitable compromise with distorted social reality. In the light of the ideal of the universal cause, nonviolence becomes the “minimum program” that should lead to the “maximum program”, where the commandment “Thou shalt not kill!” will expand into Christ’s “Raise the dead!”.
FROM LANGUAGE EVENTS TO EVENT LANGUAGE
Authors: Panyukov Anatoly V. ,   Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences
Published: July 2024

The article presents the background of the author’s concept of selfassembly of the plot. The proximity of the language of demonological stories to the spoken language requires special attention to the text, to its linguistic semantics. The linguosemantic approach to the analysis of texts, which was justified by the author, is demonstrated by the example of the concept of “to lead the water”, widely represented in mythological stories. A lot of predicative compounds were found that implement semantic transitions between two lexico-semantic nests. It is shown that the analyzed narratives are based on the actualization of intra-linguistic, potential predications (“language events”) into predicative syntagmasmythological motifs (“language of events”). The search for an answer to the question of how interactions arising in the language between different levels of the language system (intra-language predications between secondary and primary meanings of words, between literal and metaphorical meanings of idiomatic expressions, etc.) are transformed into text-building constructs led to the emergence of the concept of selfassembly of the plot.
El Impacto de Google Maps Platforms en la Eficiencia del Sector Turístico
Authors: García Castillo Luis Antonio , Catalán Villegas Arnulfo , Cuevas Valencia René E.
Published: July 2024

Este artículo posee un enfoque documental, su contenido se ha recopilado a partir de una variedad de fuentes: primarias, secundarias y terciarias. A continuación, se analiza en detalle la tecnología de Google Maps y la manera en que las empresas han capitalizado sus servicios a través de esta plataforma. Se enfoca principalmente en ámbitos ligados al sector turístico, resaltando su relevancia en este campo. La información se presenta de manera estructurada, abordando desde las tendencias más recientes en el sector turístico hasta la exposición de casos concretos que han marcado un impacto significativo mediante la creación de aplicaciones e innovaciones disruptivas en diversos segmentos que componen el ámbito turístico. Para culminar, se proporciona una conclusión basada en el análisis y la reflexión sobre la información recopilada. Al adentrarse en este artículo, el lector obtendrá una comprensión más clara acerca de los servicios que ofrece esta plataforma, los beneficios que conlleva y su impacto en la generación de nuevas tecnologías.