bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative effectiveness of glasdegib versus venetoclax combined with low-dose cytarabine in acute myeloid leukemia
Authors: Tremblay Gabriel , Daniele Patrick , Bell Timothy , Chan Geoffrey , Brown Andrew , Cappelleri Joseph C
Published: March 2021

Background:
Two combination therapies recently approved and recommended for use in combination with low-dose cytarabine (LDAC) in acute myeloid leukemia patients unfit for intensive chemotherapy are glasdegib+LDAC and venetoclax+LDAC.
Materials & methods:
An indirect treatment comparison used median overall survival, overall survival hazard ratios, complete remission (CR), CR+CR with incomplete blood count recovery and transfusion independence to assess comparative effectiveness, and a simulated treatment comparison accounted for differences in patient characteristics between trials.
Results:
Differences in efficacy between glasdegib+LDAC and venetoclax+LDAC were suggestive and not statistically significant.
Conclusion:
With no significant differences in comparative effectiveness, considerations such as safety profiles, burden of administration and patient preference are likely to guide treatment decisions.
Superação prospectiva (prospective overruling) como regra - (in)segurança jurídica em caso de virada jurisprudencial
Authors: Gomes Rodolfo Perini
Published: March 2021

O artigo trata da revogação de jurisprudência dominante, sumulada ou não, do Supremo Tribunal Federal e dos tribunais superiores, sem declaração de inconstitucionalidade, e sua correlação, de lege data (artigo 927, § 3º, do CPC/2015), com o princípio da segurança jurídica em sua vertente subjetiva. Para tanto, pautar-se-á no método de abordagem qualitativo, embasado em fontes bibliográficas. Conclui-se que a eficácia das decisões revogatórias de entendimentos jurisprudenciais consolidados há de ser, em regra, prospectiva (ex nunc), de modo a preservar as relações jurídicas travadas sob a égide da diretriz hermenêutica anterior e, pelo próprio fato, o princípio da proteção à confiança, com o objetivo de uniformizar a prestação jurisdicional diante dos efeitos expansivos/ultrapartes irradiados pelos respectivos julgados.
Juiz das garantias: o inquérito policial deve compor os autos do processo?
Authors: Suxberger Antonio Henrique Graciano
Published: March 2021

A figura do juiz das garantias, inserida no Código de Processo Penal – CPP pela Lei 13.964, de 24 de dezembro de 2019, suscitou uma série de polêmicas, e, neste artigo, será examinada uma delas, de relevante interesse prático, qual seja, a destinação do inquérito policial nos casos de instauração de processo criminal: aquele comporia os autos deste ou seria acautelado na secretaria do juízo? A análise parte da confusa redação do § 3º do art. 3º-C do CPP. Após indicada a aparente contrariedade deste parágrafo ao enunciado do art. 12 do CPP, são apresentadas e examinadas as proposições principais que versavam sobre o assunto e tramitaram no Congresso Nacional durante a elaboração da Lei 13.964/2019. O conteúdo delas bem como o CPP, a Lei Complementar 95, de 26 de fevereiro de 1998, e a Lei de Introdução às Normas do Direito Brasileiro constituem a base para a intepretação sistemática e literal do referido parágrafo. Como metodologia, foi utilizada a análise documental e a literatura sobre as funções da investigação preliminar para o processo penal de conformação acusatória. Na conclusão, sustenta-se que os autos do inquérito policial devem integrar os autos do processo-crime, salvo nas hipóteses processadas em apartado que sejam objeto de decisão do juiz das garantias.
Online disputes resolution: audiências por videoconferência e o acesso à justiça para as pessoas com deficiência
Authors: Silva Nathanne Monize Costa , Xavier Marina Corrêa
Published: March 2021

O presente artigo analisa a aplicabilidade concreta dos princípios do acesso à justiça, da duração razoável do processo e da isonomia, no contexto da realização de audiências de conciliação por videoconferência com a participação de pessoa com deficiência auditiva. Após breve apanhado teórico sobre o tema, trabalha-se o conceito de Online Dispute Resolution (ODR) e discorre-se sobre sua ampla utilização pelo TJDFT como forma de compatibilizar as audiências de conciliação com a suspensão de atos processuais determinada em razão das medidas de contenção da pandemia causada pela COVID-19. Diante do emprego da videoconferência como ferramenta para a realização das conciliações por parte dos CEJUSCs, indaga-se quais são as adaptações exigidas pela nova prática para se garantir efetivamente a inclusão das pessoas com deficiência. Com base na análise de um caso concreto vivenciado pelo CEJUSC de Ceilândia, verifica-se a possibilidade de promover a inclusão da pessoa com deficiência com o adequado emprego das novas tecnologias de modo a compatibilizar os princípios da isonomia, da duração razoável do processo e do acesso à justiça com a realização de audiências por videoconferência. Chega-se, assim, à conclusão de que a adoção do modelo de videoconferência para a realização de audiências de conciliação deve ser acompanhada de instrumentos que proporcionem o acesso ao sistema às pessoas com deficiência.
APRESENTAÇÃO - VOLUME 111, N. 2, DA REVISTA DE DOUTRINA JURÍDICA - RDJ
Authors: Brito Desa. Ana Maria Duarte Amarante
Published: March 2021

O Tribunal de Justiça do Distrito Federal e dos Territórios traz aos leitores, operadores do Direito, estudantes, pesquisadores e todos aqueles interessados no saber jurídico o volume 111, n. 2, da RDJ, com artigos científicos inéditos de temas relevantes, selecionados criteriosamente após avaliação realizada pelos pareceristas. Este primeiro volume foi elaborado com enorme entusiasmo, em razão do grande apreço da Editora-Chefe pela docência e pelo meio acadêmico. Assim, a atual gestão inicia-se com o compro- misso de elevar a RDJ ao patamar dos renomados periódicos científicos e de receber uma boa qualificação no processo da Qualis Periódico da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES. E já traz uma novidade. Os Enunciados de Súmula aprovados pelo TJDFT foram excluídos. Assim, com a publicação exclusiva de artigos científicos, a revista passa a denominar-se Revista de Doutrina Jurídica, mantida a sigla RDJ. Ressalte-se que os citados Enunciados poderão ser consulta- dos no Livro de Súmulas eletrônico, disponível no sítio deste Tribunal. Ainda com o objetivo de manter a respeitabilidade no meio acadêmico, a atual equipe executiva tem trabalhado para ampliar a divulgação da RDJ e, com isso, receber artigos de alta qualidade que representem a exogenia intelectual pátria. Como é cediço, os textos enviados por autores de todo o País são submetidos ao método double blind peer review, o processo de avaliação realizado por dois especialistas do Direito, com elevada titulação acadêmica, que inviabiliza a identificação da autoria dos articulistas e também preserva o anonimato dos avaliadores. Para aprimorar a confiabilidade e o alcance das publicações da RDJ, encontra-se em anda- mento o processo de aquisição de licença do software de detecção de plágio e do DOI (Digital Object Identiier), para a respectiva atribuição aos artigos publicados. Além disso, aguarda-se a análise da parceria entre o TJDFT e o Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT), para atualização do software Open Journal Systems (OJS), atualmente utilizado para realização de todo o fluxo editorial da RDJ.
Tax buoyancy in Jordan: Meeting the challenge after COVID-19
Authors: Khataybeh Mohammad , Omet Ghassan , Haddad Fayez
Published: March 2021

Public finance in Jordan has always been poor. Indeed, not a single Jordanian government has managed to have a surplus in its budget. In addition, and within the context of the already high, and rising public debt, COVID-19 will not only exacerbate this problem even further. This is why the main purpose of this paper is to estimate tax buoyancy in Jordan. This is a timely issue to examine because once the Jordanian economy goes back to its normal growth rates (after COVID-19), the status of the fiscal deficit (and public debt) will depend, to a large extent, on tax buoyancy. To estimate the impact of Gross Domestic Product (GDP) on tax revenues (tax buoyancy), the paper uses annual data (1992 2019) and time series techniques including stationarity tests, Johnsen cointegration test, and vector error correction model (VECM). Based on the empirical estimations, one can state that tax buoyancy in Jordan is less than one. This indicates that once the Jordanian economy goes back to its pre-COVID-19 growth rates, the increase in total tax revenues will not reciprocate the increases in GDP. This is unfortunate, given the already high existing public debt level. However, what is encouraging is the fact that sales tax and corporate tax are buoyant. The only way to increase tax buoyancy (and total tax to GDP ratio) is to make the sources of tax revenues more diversified and more progressive.
Argumentación y Política curricular para la Paz: Enfoque glotopolítico
Authors: Cisneros Estupinán Mireya , Cediel Gómez Yulia Katherine , Olave Arias Giohanny
Published: March 2021

Este libro se deriva de dos proyectos inscritos en la Vicerrectoría de Investigaciones, Innovación y Extensión de la Universidad Tecnológica de Pereira (UTP): el primero, «Introducción de los estudios glotopolíticos en la formación profesional de docentes de lenguaje en Colombia», identificado con el código CIE 4-19-3, que busca contribuir a la introducción de la perspectiva glotopolítica en los estudios lingüísticos contemporáneos en Colombia (Cisneros-Estupiñán y Olave-Arias, 2018); el segundo, titulado «Contribuciones de los estudios del discurso a la transición hacia la paz en Colombia», con código CIE 4-19-1, que tiene como objetivo adelantar acciones investigativas, formativas y divulgativas desde los estudios del discurso en la Maestría en Lingüística de la UTP, que contribuyan a la transición contemporánea hacia la paz en Colombia.
Side effects of triazoles on treated crops
Authors: Jakl Michal , Zeljković Sanja Ćavar , Kovač Ishak , Bělonožníková Kateřina , Dytrtová Jana Jaklová
Published: March 2021

Triazolic fungicides are widely applied in crop production to protect
plants against fungal pathogens. However, they may influence the
biochemical processes in plants and other non-target species. This paper
is aimed at the effect of triazoles (namely tebuconazole, cyproconazole,
and penconazole) single/mixed applications on the phenolics production
in tomato (Solanum lycopersicum L.) fruit peel, amount of
chlorophyll a and b in tomato leaves as well as on basic
plant growth parameters. For this purpose, cherry tomatoes were planted
in the pot experiment and foliarly-treated weekly, with the same total
triazoles dose of 3.52 μmol per plant (in mixtures of 1.71 or 1.17 μmol
of each in two or three components, respectively). The treatments
increased the weight of fruits in the 1 harvest
about 43%, however, this effect was not observed in the next harvest.
Increased oxidative stress in the triazoles presence was observed, based
on the elevated production of antioxidant phenolics in the
1 harvest. Most alarming is the decrease of the
weight of thin stems and foliage and the concentration of
chlorophyll a (b) in leaves in all triazoles-treated
variants. The non-target impacts on plant biochemical processes (related
to the phenolics or chlorophylls production and functionality) were
confirmed.
Evaluation of the predictive power of d-dimer/albumin ratio and fibrinogen/albumin ratio for in-hospital mortality in COVID-19 patients
Authors: Küçükceran Kadir , Ayrancı Mustafa Kürşat , Girisgin Sadik , Koçak Sedat , Dündar Zerrin Defne
Published: March 2021

Introduction: Due to the high mortality of coronavirus disease 2019
(COVID-19), There are difficulties in the management of the emergency
department. As such, we investigated whether the d-dimer/albumin ratio
(DAR) and fibrinogen/albumin ratio (FAR) predicts mortality in the
COVID-19 patients. Methods: A total of 717 COVID-19 patients who were
brought to the emergency department within the period from March to
October 2020 were included in the study. The d-dimer level, fibrinogen
level, albumin level, DAR, FAR, age, gender, and in-hospital mortality
status of the patients were recorded. The patients were grouped by
in-hospital mortality. Statistical comparison was conducted between the
groups. Results: Of the patients who were included in the study,
371(51.7%) were male, and their median age was 64 years (50–74). There
was in-hospital mortality in 126 (17.6%) patients. The
area-under-the-curve (AUC) and odds ratio values obtained by DAR to
predict in-hospital mortality were higher than the values obtained by
the all other parameters (AUC of DAR, albumin, d-dimer, FAR, and
fibrinogen: 0.773, 0.766, 0.757, 0.703, and 0.637, respectively; odds
ratio of DAR>56.36, albumin<4.015,
d-dimer>292.5, FAR>112.33, and
fibrinogen>423: 7.898, 6.216, 6.058, 4.437, and 2.794,
respectively). In addition; patients with concurrent
DAR>56.36 and FAR>112.33 had an odds ratio of
21.879 referring to patients with concurrent DAR<56.36 and
FAR<112.33. Conclusion: DAR was found to be more valuable than
the other parameters. In addition the concurrent high levels of DAR and
FAR levels were found to be more valuable in predicting in-hospital
mortality compared to a separate evaluation. Keywords: Covid-19,
D-dimer, Fibrinogen, Serum Albumin, in-Hospital Mortality
Primary bladder angiosarcoma synchronous with prostatic acinar adenocarcinoma in an 82-year-old male
Authors: Paranici Cătălina , Achim Sanda , Enache Valentin
Published: March 2021

Primary bladder angiosarcoma is a rarely encountered and poorly described malignancy. Only 34 cases have been described in the English literature according to PubMed, accounting for only 2% of the genitourinary soft tissue sarcomas and 0.6% of all bladder tumors. We report a case of a primary angiosarcoma of the urinary bladder in an 82-year-old patient and present the clinical history, histopathological and immunohistochemical features of this tumor, in order to provide better understanding of the diagnosis, possible therapies and clinical outcome.
A very rare case of FLT3-D835 positive blastic plasmacytoid dendritic cell neoplasm
Authors: Cianga Vlad Andrei , Dănăilă Cătălin Doru , Antohe Ion
Published: March 2021

Blastic plasmacytoid dendritic cell neoplasms (BPDCNs) are extremely rare and aggressive hematological malignancies that derive from precursors of plasmacytoid dendritic cells (pDC) and frequently involve skin lesions and bone marrow infiltration. They mostly affect the elderly population and the prognosis is poor with the therapeutic choices currently available. Diagnosis is made with the help of tools such as immuno-histochemistry and flow cytometry. Here, we present a particular case of BPDCN with a positive FLT3-D835 mutation and we discuss the possible impact this may have on the evolution of the disease and response to treatment.
Chains of three-dimensional evolution algebras: A description
Authors: Imomkulov Anvar , Velasco Victoria
Published: March 2021

In this paper we describe locally all the chains of three-dimensional
evolution algebras (3-dimensional CEAs). These are families of evolution
algebras with the property that their structure matrices with respect to a
certain natural basis satisfy the Chapman-Kolmogorov equation. We do it by
describing all 3-dimensional CEAs whose structure matrices have a fixed rank
equal to 3, 2 and 1, respectively. We show that arbitrary CEAs are locally
CEAs of fixed rank. Since every evolution algebra can be regarded as a
weighted digraph, this allows us to understand and visualize time-dependent
weighted digraphs with 3 nodes.
Operator matrices and their Weyl type theorems
Authors: An Ju , Ko Eungil , Lee Ji
Published: March 2021

We denote the collection of the 2 x 2 operator matrices with (1,2)-entries
having closed range by S. In this paper, we study the relations between the
operator matrices in the class S and their component operators in terms of
the Drazin spectrum and left Drazin spectrum, respectively. As some
application of them, we investigate how the generalized Weyl?s theorem and
the generalized a-Weyl?s theorem hold for operator matrices in S,
respectively. In addition, we provide a simple example about an operator
matrix in S satisfying such Weyl type theorems.
INverse problem of identifying a time-dependent coefficient and free boundary in heat conduction equation by using the meshless local Petrov-Galerkin (MLPG) method via moving least squares approximation
Authors: Karami Akbar , Abbasbandy Saeid , Shivanian Elyas
Published: March 2021

In this paper we investigated the inverse problem of identifying an unknown
time-dependent coefficient and free boundary in heat conduction equation. By
using the change of variable we reduced the free boundary problem into a
fixed boundary problem. In direct solver problem we employed the meshless
local Petrov-Galerkin (MLPG) method based on the moving least squares (MLS)
approximation. Inverse reduced problem with fixed boundary is nonlinear and
we formulated it as a nonlinear least-squares minimization of a scalar
objective function. Minimization is performed by using of f mincon routine
from MATLoptimization toolbox accomplished with the Interior - point
algorithm. In order to deal with the time derivatives, a two-step time
discretization method is used. It is shown that the proposed method is
accurate and stable even under a large measurement noise through several
numerical experiments.
Some novel inequalities involving a function’s fractional integrals in relation to another function through generalized quasiconvex mappings
Authors: Nwaeze Eze , Kashuri Artion
Published: March 2021

In this paper, we establish new inequalities of the Hermite-Hadamard,
midpoint and trapezoid types for functions whose first derivatives in
absolute value are ?-quasiconvex by means of generalized fractional integral
operators with respect to another function ? : [?,?] ? (0,?). Our theorems
reduce to results involving the Riemann-Liouville fractional integral
operators if ? is the identity map, and results involving the Hadamard
operators if ?(x) = ln x. More inequalities can be deduced by choosing
different bifunctions for ?. To the best of our knowledge, the results
obtained herein are new and we hope that they will stimulate further
interest in this direction.
Schatten-von Neumann characteristic of tensor product operators
Authors: Ipek Al Pembe , Ismailov Zameddin
Published: March 2021

In this paper, the relations between Schatten-von Neumann property of the
tensor product of operators and Schatten-von Neumann property of its
coordinate operators are studied.
Generalized hypergeometric identities with extra parameters
Authors: Masjed-Jamei Mohammad , Milovanovic Gradimir
Published: March 2021

Anew class of hypergeometric identities with extra parameters is introduced
in order to generate various kinds of summation theorems for generalized
hypergeometric series. Some interesting examples are also given in this
direction.
Several identities of classical, complementary and generalized Euler numbers
Authors: Komatsu Takao , Li Rusen
Published: March 2021

In this paper, we establish several interesting identities and congruences
involving classical, complementary and generalized Euler numbers, by using
generating functions.
Developmental hypomineralization of the enamel of the first permanent and the second deciduous molars - report of two cases
Authors: Hocevar Luka , Mandinic Zoran , Mandic Jelena , Pavlic Alenka
Published: March 2021

Introduction. Molar-incisor hypomineralization (MIH) is a developmental defect of dental enamel that affects one to all four first permanent molars (FPM) and frequently permanent incisors. Enamel aberrations are observed as demarcated opacities of different colors (from white to brown) and as posteruptive enamel breakdown. Clinically similar pathological signs can also be present in deciduous molars. Case outline. Histology of an FPM and a second deciduous molar was performed after extraction from two unrelated patients with MIH due to inflammatory complications. Tooth samples were analyzed using a stereomicroscope (SM), light microscope (LM), and scanning electron microscope (SEM). Enamel thickness of both affected teeth was normal. An obvious distinction in enamel microstructure was observed between the normally developed and the molar-incisor hypomineralized enamel with SM, LM, and SEM. Conclusion. In MIH patients, regular dental visits enable early diagnosis of the disease and appropriate treatment of the patient as soon as possible, with included preventive measures.
Partially stabilized zirconia (3Y-ZrO2) aluminum borate (Al18B4O33) needles composite materials by direct sintering
Authors: Martinez Juan , Hernández María , Booth Fernando , Lopez Paula , Suarez Gustavo , Conconi María , Rendtorff Nicolás
Published: March 2021

Novel 1:1 Yttria partially stabilized zirconia (PSZ) - aluminum borate (AB:
Al11B4O33) ceramic composites were prepared and characterized by a simple
direct sintering process of PSZ-mixtures. Sintering was performed below
1300?C to minimize the decomposition of borate. Phases were corroborated by
XRD. SEM permitted to characterize the microstructure as interlocking
needles of - rounded by PSZ grains. Porous microstructure configuration
was achieved by the proposed processing route. Porosity was within 30% for
samples thermally treated at 1200 and 1300?C. Mechanical behavior was
evaluated by diametral compression. A fragile behavior was observed. Both
strength and apparent Young modulus were evaluated being ?30 MPa and ?3 GPa
respectively; values four times higher than the corresponding alumina-AB
composite. This is more important when firing at higher temperature. The
density of the obtained composites coupled with the mechanical behavior are
the main characteristics of this novel composite with potential structural,
insulating and filtering applications.
Fast oxide-ion conductors in Bi2O3-V2O5 system: Bi108-xVxO162+x(x=4-9) with 3×3×3 superstructure
Authors: Dapcevic A. , Radojkovic A. , Zunic M. , Pocuca-Nesic M. , Milosevic O. , Brankovic G.
Published: March 2021

In this study, the possibility to stabilize O2-ion conductors in Bi2O3-V2O5
system was investigated. Six pseudo-binary Bi2O3-V2O5 mixtures [3.50 <
x(V2O5) < 8.50 mol%] were thermally treated at 1000?C for 1 h. The samples
were characterized by XRD, HRTEM/SAED, DTA and EIS techniques. The
high-temperature reaction between ? Bi2O3 and V2O5 resulted in formation of
microcrystalline single-phase specimens containing the phase based on
?-Bi2O3 if V2O5 content was ? 4.63 mol%. The obtained phases exhibited main
diffraction peaks corresponding to the simple cubic ?-Bi2O3 (space group
Fm-3m) but Rietveld refinement showed a threefold repeat on a simple cubic
sublattice indicating that the true unit cell is 3?3?3 supercell. Within
proposed supercell, the octahedrally coordinated V5+ ions fully occupy 4a
Wyckoff position and partially occupy 32f. The Bi3+ ions are placed at the
rest of 32f and at 24e and 48h with full occupation. In total, 22 % of
anionic sites are vacant. The ionic conductivity of phase with the lowest
dopant content, i.e. Bi 103V5O167, amounts 0.283 S cm-1 at 800?C with the
activation energy of 0.64(5) eV, which is comparable to the undoped ?-Bi2O3
known as the fastest ion conductor.
Enhancing the electrical properties of inkjet-printed silver ink by electrolyte sintering, photonic sintering, and electroless plating
Authors: Mukai Yusuke , Suh Minyoung
Published: March 2021

Conductive inkjet printing is an emerging rapid manufacturing technology in
the field of smart clothing and wearable electronics. The current challenge
in conductive inkjet printing includes upgrading of electrical performance
of printed inks to the equivalent level to traditional conductors such as
bulk silver and copper, especially for high-performance electronic
applications such as flexible antennas and circuits. Post-treatments are
commonly employed to enhance the electrical conduction of inkjet-printed
tracks. This research discusses the effects of electrolyte sintering,
photonic sintering and electroless copper plating on the DC electrical
resistance and resistivity of inkjet-printed silver nanoparticles. From
experimental results and measurements, it was found that all the
post-treatment methods effectively improved the electrical properties of
printed silver ink, but in different ways. The lowest resistance of 4.5 ?
(in 0.1 mm ? 10 mm) and thickest (4.5 ?m) conductor were achieved by
electroless copper plating, whereas the lowest resistivity (7.5?10-8 ??m)
and thinnest (1.0 ?m) conductor were obtained by photonic sintering.
Numerical evaluation of the elastic properties of carbon fiber reinforced composite material at elevated and lowered temperatures
Authors: Saleem Alteer , Petrovic Veljko , Grbovic Aleksandar , Lozanovic-Sajic Jasmina , Balac Igor
Published: March 2021

The effect of elevated and lowered temperatures on the elastic properties of
carbon fiber-epoxy composite material was studied using multi-phase unit
cell (MPUC) numerical model. Evaluation of the elastic properties of carbon
fiber-epoxy composite material is based on the finite element method.
Obtained results confirmed that elevated and lowered temperature has
noticeable influence on elastic properties of carbon fiber-epoxy composite
material. As demonstrated, this fact has considerable influence on accurate
evaluation of generated thermal stresses in real laminated composite
structures, exposed to extremely high or low operating temperatures.
Frank Lewis Clarke (1933–2020): An International Journey in Quest of a More Serviceable Accounting
Authors: Dean Graeme W. , Persson Martin E. , Sargiacomo Massimo
Published: March 2021

SYNOPSIS

Frank Lewis Clarke (1933–2020), a member of the Sydney School of Accounting, was a keen observer of business practices, successes, and failures, an international journeyman for better accounting standards, an influential accounting academic, and a master teacher. This memorial considers Clarke's early childhood, education, and his contribution to accounting scholarship. During a career spanning several decades, Clarke published over 50 articles in scholarly journals, a dozen books, smaller pieces in professional outlets and popular press, and many submissions to professional and governmental inquiries. Ideas were exposed in presentations at conferences nearly every year. His prodigious output addressed, generally, how to improve the usefulness of accounting data in respect to the uses ordinarily made of them. Much of his research examined accounting anomalies revealed in analyses of corporate financial dilemmas and unexpected corporate collapses. He leaves behind a legacy that highlights the need for a more serviceable accounting.

JEL Classifications: M41; M42; M48.
Nanopore 16S Amplicon Sequencing Enhances the Understanding of Pathogens in Medically Intractable Diabetic Foot Infections
Authors: Moon Jangsup , Kim Narae , Lee Han Sang , Lee Soon-Tae , Jung Keun-Hwa , Park Kyung-Il , Lee Sang Kun , Lee Dong-Oh , Lee Dong Yeon , Chu Kon
Published: March 2021

Diabetic foot infections (DFIs) cause substantial morbidity and mortality. The mainstay of the treatment is empiric antibiotics and surgical debridement in severe cases. In this study, we performed nanopore 16S rDNA sequencing from the debridement specimens of DFIs. Fifty-four surgical debridement specimens obtained from 45 patients with medically intractable DFI were included. The 16S rDNA PCR was performed on each specimen, and Nanopore sequencing was performed for up to 3 h. The reads were aligned to the BLAST database, and the results were compared with conventional culture studies. The 16S sequencing results revealed that the majority of the DFIs (44 of 54, 81.5%) were polymicrobial infections. All bacteria isolated by conventional culture studies were detected by 16S sequencing. Several anaerobes (Prevotella, Finegoldia, Anaerococcus, Bacteroides) were commonly identified by 16S sequencing but were frequently missed by culture studies. In many cases, certain bacteria only revealed by the 16S sequencing were more abundant than the bacteria isolated by the culture studies. In conclusion, nanopore 16S sequencing was capable of pathogen identification in DFIs and has many advantages over conventional culture studies. Nanopore 16S sequencing enables a comprehensive understanding of the bacteria involved in DFIs.
T-Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early Diabetes
Authors: Forbes Josephine M. , McCarthy Domenica A. , Kassianos Andrew J. , Baskerville Tracey , Fotheringham Amelia K. , Giuliani Kurt T.K. , Grivei Anca , Murphy Andrew J. , Flynn Michelle C. , Sullivan Mitchell A. , Chandrashekar Preeti , Whiddett Rani , Radford Kristen J. , Flemming Nicole , Beard Sam S. , D’Silva Neisha , Nisbet Janelle , Morton Adam , Teasdale Stephanie , Russell Anthony , Isbel Nicole , Jones Timothy , Couper Jennifer , Healy Helen , Harris Mark , Donaghue Kim , Johnson David W. , Cotterill Andrew , Barrett Helen L. , O’Moore-Sullivan Trisha
Published: March 2021

Half of the mortality in diabetes is seen in individuals <50 years of age and commonly predicted by the early onset of diabetic kidney disease (DKD). In type 1 diabetes, increased urinary albumin-to-creatinine ratio (uACR) during adolescence defines this risk, but the pathological factors responsible remain unknown. We postulated that early in diabetes, glucose variations contribute to kidney injury molecule-1 (KIM-1) release from circulating T cells, elevating uACR and DKD risk. DKD risk was assigned in youth with type 1 diabetes (n = 100; 20.0 ± 2.8 years; males/females, 54:46; HbA1c 66.1 [12.3] mmol/mol; diabetes duration 10.7 ± 5.2 years; and BMI 24.5 [5.3] kg/m2) and 10-year historical uACR, HbA1c, and random blood glucose concentrations collected retrospectively. Glucose fluctuations in the absence of diabetes were also compared with streptozotocin diabetes in apolipoprotein E−/− mice. Kidney biopsies were used to examine infiltration of KIM-1–expressing T cells in DKD and compared with other chronic kidney disease. Individuals at high risk for DKD had persistent elevations in uACR defined by area under the curve (AUC; uACRAUC0–10yrs, 29.7 ± 8.8 vs. 4.5 ± 0.5; P < 0.01 vs. low risk) and early kidney dysfunction, including ∼8.3 mL/min/1.73 m2 higher estimated glomerular filtration rates (modified Schwartz equation; Padj < 0.031 vs. low risk) and plasma KIM-1 concentrations (∼15% higher vs. low risk; P < 0.034). High-risk individuals had greater glycemic variability and increased peripheral blood T-cell KIM-1 expression, particularly on CD8+ T cells. These findings were confirmed in a murine model of glycemic variability both in the presence and absence of diabetes. KIM-1+ T cells were also infiltrating kidney biopsies from individuals with DKD. Healthy primary human proximal tubule epithelial cells exposed to plasma from high-risk youth with diabetes showed elevated collagen IV and sodium–glucose cotransporter 2 expression, alleviated with KIM-1 blockade. Taken together, these studies suggest that glycemic variations confer risk for DKD in diabetes via increased CD8+ T-cell production of KIM-1.
T Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early Diabetes
Authors: Forbes Josephine M. , McCarthy Domenica A. , Kassianos Andrew J. , Baskerville Tracey , Fotheringham Amelia J. , Giuliani Kurt T.K. , Grivei Anca , Murphy Andrew J. , Flynn Michelle C. , Sullivan Mitchell A. , Chandrashekar Preeti , Whiddett Rani , Radford Kristen J. , Flemming Nicole , Beard Sam S. , D’Silva Neisha , Nisbet Janelle , Morton Adam , Teasdale Stephanie , Russell Anthony , Isbel Nicole , Jones Timothy , Couper Jennifer , Healy Helen , Harris Mark , Donaghue Kim , Johnson David W. , Cotterill Andrew , Barrett Helen L. , O’Moore-Sullivan Trisha
Published: March 2021

Half of the mortality in diabetes is seen
in individuals <50 years of age and commonly predicted by the early onset of
kidney disease (DKD). In Type 1 diabetes, increased uACR (urinary
albumin-creatinine ratio) during adolescence defines this risk, but the
pathological factors responsible remain unknown. We postulated that early in
diabetes, glucose variations contribute to kidney injury molecule- 1 (KIM-1)
release from circulating T cells, elevating uACR and DKD risk.

DKD risk was assigned in youth with type
1 diabetes [n=100; 20.0±2.8 yrs; M:F-54:46, HbA1C-66.1(12.3)
mmol/mol; diabetes duration-10.7±5.2 yrs; BMI-24.5(5.3) kg.m-2]
and 10 year historical uACR, HbA1C and random blood glucose
concentrations collected retrospectively. Glucose fluctuations in the absence
of diabetes were also compared to streptozotocin diabetes in Apolipoprotein
E-/- mice. Kidney biopsies were used to examine infiltration of KIM-1
expressing T cells in DKD and compared with other chronic kidney disease.

Individuals at high risk for DKD had
persistent elevations in uACR (uACRAUC0-10yrs, 29.7±8.8 vs
4.5±0.5; P<0.01
vs low risk) and early kidney dysfunction including ~8.3ml.min-1.1.73m-2
higher estimated glomerular filtration rates (eGFRSCHWARTZ; Padj <0.031 vs low risk)
and plasma KIM-1 concentrations (~15% higher vs low risk; P<0.034). High risk individuals had greater glycemic
variability and increased peripheral blood T cell KIM-1 expression, particularly
on CD8+ T cells. These findings were confirmed in a murine model of glycemic
variability both in the presence and absence of diabetes. KIM-1+ T cells were
also infiltrating kidney biopsies from individuals with DKD. Healthy primary human
proximal tubule epithelial cells exposed to plasma from high risk youth with diabetes
showed elevated collagen IV and SGLT2 expression, alleviated with KIM-1
blockade. Taken together, these studies suggest that glycemic variations confer
risk for DKD in diabetes via increased CD8+ T cell production of KIM-1.
Penggunaan Model Pembelajaran Kooperatif Tipe Students Teams Achievement Divisions (STAD) untuk Meningkatkan Hasil Belajar Jasa Boga Materi Pengolahan Soup
Authors: Kusumastuti Eni
Published: March 2021

Kemajuan sector pariwisata khususnya bidang kuliner terus mengalami peningkatan. Hal ini sejalan dengan program sekolah kejuruan yang mencetak lulusan siap kerja. Salah satu menu tata boga yang sering kita jumpai dalam menu nasional maupun internasional adalah soup. Soup yang sesuai dengan standar menu hotel pariwisata membutuhkan pengolahan dan penyajian dengan prosedur yang tepat. SMKN 1 Dlanggu menangkap momentum tersebut dengan meningkatkan kompetensi siswa bidang Tata Boga. Penelitian tindakan kelas ini bertujuan meningkatkan kompetensi siswa dalam mengolah dan menyajikan soup dengan menerapkan tiga aspek yaitu konsistensi, warna, dan rasa. Model pembelajaran yang dipilih peneliti adalah menggunakan mode kooperatif tipe Students Teams Achievement Divisions (STAD). Model ini peneliti ambil dengan dasar bahwa untuk meningkatkan kompetensi siswa tidak hanya didapat dari guru sebgai sumber utama, namun juga sikap tolong-menolong dalam tim untuk menyelesaikan masalah. Penelitian ini dilakukan pada siswa kelas XI TB 3 SMKN 1 Dlanggu tapel 2019/2020 semester gasal dengan lama penelitian 4 bulan yaitu dari September sampai Desember 2019
Büyük ve Küçük Şirketlerin Finansal Performanslarındaki Farklılıklar: Borsa İstanbul’da İşlem Gören Konaklama Şirketlerinde Bir Araştırma
Authors: Karadeniz Erdinç , Beyazgül Mehmet
Published: March 2021

Bu araştırmanın amacı, büyük ve küçük konaklama şirketlerinin finansal performansları arasındaki farklılıkları tespit etmektir. Bu amaçla 2012-2019 yılları arasında Borsa İstanbul’da işlem gören konaklama şirketleri, aktif toplamlarının ortanca değerine göre büyük ve küçük olarak ayrılmıştır. Daha sonra büyük ve küçük konaklama şirketlerinin likidite, finansal yapı, faaliyet, karlılık ve piyasa performans oranları hesaplanmış ve Mann Whitney U farklılık testi uygulanmıştır. Analiz sonucunda küçük şirketlerin likidite, finansal yapı, faaliyet, karlılık ve piyasa performansı açısından büyük şirketlere göre daha başarılı oldukları saptanmıştır. Ayrıca hesaplanan bütün oranlar açısından büyük ve küçük şirketler arasında istatistiksel olarak anlamlı bir fark bulunmuştur.
Gastronomi Turizmi Kapsamında Yöresel Yemeklerin Restoranlarda Sunulması Üzerine Bir Araştırma: Şarköy Örneği
Authors: Kızıldemir Özgür , Şimşek Enver
Published: March 2021

Bu çalışmanın amacı, Tekirdağ’a bağlı Şarköy yöresinde bulunan restoranların, bölgeye ait yöresel yemeklerinin menülerinde yer alma durumunu tespit edip, gastronomi turizmi çerçevesinde değerlendirmektir. Amaca ulaşabilmek adına alan yazın incelenmiş, nitel araştırma yöntemlerinden yarı yapılandırılmış görüşme tekniği ile Şarköy yöresindeki 8 restoran yetkilisinden veriler toplanmıştır. Yerel halkın yemek türlerinde zeytinyağı ve tahıl ürünlerini sıklıkla kullandıkları anlaşılmıştır. Mülakatlar sonucunda, Şarköy’ün yöresel yemeklerinin çok fazla uğraş gerektiren yemekler olması sebebiyle restoranlarda yeterli düzeyde sunulmadığı, diğer sebebin ise talep düşüklüğü olduğu saptanmıştır. Katılımcılar, yöresel yemeklerin tanıtımı için belediye reklam desteklerinin sağlanması, Şarköy yöresinin genel tanıtımının yapılması, gastronomi festivalleri yapılması ve festivallere katılım sağlanması gerektiğini belirtmişlerdir.
Effects of Question Prompts in Web-Based Video Analysis System on Pre-service Teachers’ Reflective Thinking
Authors: YILDIZ İsmail , TOKEL Saniye
Published: March 2021

In this study, in order to facilitate pre-service teachers’(PSTs) peer-interaction and reflective thinking during their microteaching process, a web-based video analysis environment was designed. The purpose of this study is to examine the effects of generic and directed scaffolds embedded within this environment on PSTs’ reflective thinking while they are making the reflection on peers’ microteaching video. For this purpose, a true experimental study was designed and applied. 55 PSTs were enrolled in this study. Findings of this study revealed that the use of directed question prompts embedded in a web-based video analysis system has a positive significant effect on PSTs' reflective thinking level.
PENGARUH PROFITABILITAS, LIKUIDITAS, KEBIJAKAN DEVIDEN DAN KEPUTUSAN INVESTASI TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN SEKTOR REAL ESTATE DAN PROPERTY YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) PERIODE TAHUN 2012-2016
Authors: Sibarani Choms Gary Ganda Tua
Published: March 2021

Penelitian ini bertujuan untuk mengetahui pengaruh Profitabilitas, Likuiditas, Kebijakan Deviden dan Keputusan Investasi terhadap Nilai Perusahaan pada perusahaan sektor real estate dan property yang terdaftar di Bursa Efek Indonesia (BEI) periode tahun 2012-2016. Variabel independen dalam penelitian ini adalah nilai perusahaan. Variable dependennya adalah Profitabilitas, Likuiditas, Kebijakan Deviden dan Keputusan Investasi. Populasi penelitian meliputi semua perusahaan sektor real estate dan property yang terdaftar di Bursa Efek Indonesia (BEI) periode tahun 2012-2016. Metode pengambilan sampel dalam penelitian ini adalah dengan menggunakan metode purposive sampling. Populasi data penelitian sebanyak 48 perusahaan, dan diperoleh sampel  sebanyak 17 perusahaan. Data penelitian ini diperoleh melalui situs Bursa Efek Indonesia (www.idx.co.id). Metode analisis yang digunakan adalah regresi linier berganda. Berdasarkan hasil analisis data menunjukkan bahwa: (1.) Profitabilitas berpengaruh positif dan signifikan terhadap nilai perusahaan. (2.) Likuiditas berpengaruh negatif dan signifikan terhadap nilai perusahaan. (3.) Kebijakan Deviden tidak berpengaruh dan tidak signifikan terhadap nilai perusahaan. (4.) Keputusan Investasi berpengaruh positif dan signifikan terhadap nilai perusahaan. (5.) Secara simultan Profitabilitas, Likuiditas, Kebijakan Deviden dan Keputusan Investasi berpengaruh positif dan signifikan terhadap Nilai Perusahaan pada perusahaan sektor real estate dan property yang terdaftar di Bursa Efek Indonesia (BEI) periode tahun 2012-2016.
On aspect of reducing bank risks of corporate loan
Authors: Ushanov Aleksandr Evgenievich
Published: March 2021

The article considers stagnation of lending by Russian commercial banks to corporate borrowers in the recent years. It has been proved that banks are more willing to invest their free credit resources in the financial sector, rather than the real sector of the economy, or place them on correspondent accounts and deposits with the Bank of Russia in the conditions of a continuing liquidity surplus, as well as taking into account the growth of overdue loan arrears. The necessity of stimulating measures at the micro-economic and macro-economic levels is justified. The basic condition for reducing credit risks is not only to improve the financial condition of borrowers and increase the profitability of their activities, but also to build a carefully verified, risk-oriented mechanism for reviewing loan applications. The elements of the new lending process are listed: updated mechanism for setting limits and risk profiles, mandatory participation in the approval of an underwriter’s application, using models in the analysis of transaction risk. The participants and main operations in the new lending process are illustrated. The stages of considering an application of a potential borrower for a loan are discussed in detail. Measures to support banks lending to the economy at the state level are also formulated, among which are: limiting the ability to invest borrowed funds in financial instruments, improving the legal framework for the practical large-scale development of mergers and acquisitions, developing a long-term concept of the investment process for using the internal resources of the country’s economy, foreseeing tax benefits, refinancing commercial banks on preferential terms for investment projects, expanding the practice of issuing government guarantees for bank loans, etc.
Teaching to Self-Regulate in Mathematics: A Quasi-Experimental Study with Low-Achieving Elementary School Students
Authors: Trias Seferian Daniel , Mels Auman Cindy , Huertas Martínez Juan Antonio
Published: March 2021

Teaching students to self-regulate enhances their mathematics performance, yet few studies have investigated the long-term differential impact of particular self-regulation strategies specifically for low-achieving students. This quasi-experimental study evaluates the effect of teaching different self-regulation strategies on mathematical problem solving in low-achieving students. The participants were 69 sixth-grade elementary school students randomly assigned to one of three experimental groups (and taught predominantly cognitive, metacognitive or volitional strategies, while verifying intervention fidelity) or a control group for 16 sessions. Mathematical problem-solving skills were evaluated prior to the intervention, upon completion, and two months later. While all three intervention groups obtained significantly better results compared to the control group immediately after the intervention, volitional and metacognitive strategies showed the strongest and most lasting positive effects. We conclude that low-achieving students could benefit from learning self-regulation strategies, particularly when these strategies take into account the affective and motivational dynamics of learning.
Migración de retorno en México y su bilingüismo. Revisión de la literatura 2006-2018
Authors: Velasco Zárate Kalinka
Published: March 2021

Se presenta una revisión de la literatura sobre los estudiantes migrantes de retorno en el sistema educativo en México, la cual incluyó artículos de investigación y otros textos académicos disponibles publicados en el período 2006-2018. La revisión permitió identificar los métodos investigativos y temáticas de estudio: una tipología de estos estudiantes basada en variables como edad, nacionalidad y estatus migratorio, condiciones al ingreso y las necesidades surgidas durante su estancia en el contexto educativo. También emergió un perfil educativo, con base en información sobre sus características psicológicas, experiencias lingüísticas y escolares previas, así como aspectos relacionados con la convivencia escolar e integración social. Aunque la investigación existente es útil para conocer algunas características y necesidades al retorno, aún son necesarios estudios que indaguen aspectos como la relación bilingüismo-desarrollo académico en los distintos niveles educativos.
PENGARUH STRUKTUR PENGENDALIAN INTERNAL, TATA KELOLA DAN ANALISIS RISIKO KEUANGAN TERHADAP EFEKTIVITAS PENYALURAN KREDIT PADA KOPERASI SIMPAN PINJAM DI KABUPATEN ACEH BESAR
Authors: Hariyati Suci , BZ Fazli Syam
Published: March 2021

The purpose of this study was to determine the effect of internal control structures, governance, and financial risk analysis on the effectiveness of credit distribution to savings and loan cooperatives in Aceh Besar District. The data used in this study are primary data using a quantitative approach. This study uses purposive sampling method in determining the sample, and there are 10 cooperatives that become samples that meet the criteria.Based on the research results, it shows that the structure of internal control, governance, and financial risk analysis together has a significant effect on the effectiveness of lending. The magnitude of the influence of internal control, governance and financial risk analysis on the effectiveness of lending was 63.8%. The internal control structure has a significant effect on the effectiveness of lending. Governance does not have a significant effect on the effectiveness of lending. Financial risk analysis has no significant effect on the effectiveness of lending
Evaluation of Antibacterial Activities of Stryax Liquidus on Staphylococcus aureus on Stainless Steel Surface
Authors: KEYVAN Erhan , SAVAŞ Menendi Merve
Published: March 2021

Sığla tree (Liquidambar orientalis Miller) is an endemic species and the styrax liquidus obtained from its extract has antiparasitic and antibacterial properties. Staphylococcus aureus is an important agent of mastitis, it can be found in milk and on the milk collection tank surfaces and the toxins it secretes may cause food poisoning. In this study; It was aimed to investigate the effects of the styrax liquidus solution applied for different periods on the bacterial culture applied to the stainless-steel surface experimentally. As a result of the study, it was determined that styrax liquidus was effective on S. aureus in all concentrations on the surface of the bulk tank milk at 5%, 10%, 15% and 20% concentrations. It was determined that styrax liquidus was reduced population of S. aureus level of 7.94 log cfu/ml. Styrax liquidus could be used as a natural antimicrobial agent in industrial surface cleaning. This is the first study to determine the disinfection properties of styrax liquidus.