bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic modeling in the functioning of security systems in the field of information security
Authors: Konakov A. M. , Pevneva A. G.
Published: January 2024

Objective. The purpose of the study is the functionality of designing, building and implementing protection systems taking into account the time factor. Method. The analysis of the functional interaction of the construction of three sequentially interconnected dynamic models and data transfer between them is carried out. Result. A general model of the system of protection and forecasting of possible threats in ensuring the security of information and infrastructure, taking into account the time factor, has been developed and proposed for implementation. Conclusion. The field of information security considered in the article is a necessary component of ensuring the protection of information resources and related systems from various threats. The application of the basics of dynamic modeling of data, processes and structures in terms of time, allows you to assess risks and threats, identify certain significant shortcomings and eliminate them, thereby optimizing costs, increasing the efficiency of ensuring security
Development of methods for neutralizing «Zero-day» threats
Authors: Dubrovina A. I. , Alcordi M. H.
Published: January 2024

Objective. The purpose of this study is to develop and analyze methods for neutralizing «zero-day» threats in order to increase the level of cybersecurity and protection of information systems. Method. In this article, a behavioral analysis of the threat is used. The characteristic features of the zero-day exploit behavior have been studied. The threat model is based on solving the tasks of timely detection and neutralization of the threat. Result. The actual problem of information systems security - the threat of «zero-day» is considered. The review of existing neutralization methods and discussion of effective new approaches were carried out. It has been revealed that the main vulnerability is outdated threat signatures. Threat detection is based on a study of the behavior of software a comparison with the previous day tracking is possible mainly by analyzing log files taken from an automated workplace. Conclusion. The content of this work emphasizes the importance of developing methods to neutralize «zero-day» threats in order to avoid the centralized spread of vulnerability and infection of a large number of automated workplaces, which can lead to the suspension of production processes within a large enterprise.
Stikstof, falend beleid en radicaliserende boeren
Authors: Loopmans Maarten
Published: January 2024

Boekbespreking van Van der Ploeg, J.D.(2023) Gesloten vanwege Stikstof, Amersfoort: Noordboek, pp. 182.
Protective Properties of Ablated Cerium Oxide Nanoparticles for Cell Cultures under Conditions of Oxidative Stress under Ultraviolet and Ionizing Irradiation
Authors: Pugachevskii M. A. , Mamontov V. A. , Kryukov A. A. , Dodonova S. A. , Artyushkova E. B. , Pikkiev V. A.
Published: January 2024

Purpose. Study of the protective properties of ablated cerium oxide nanoparticles for cell cultures in an oxidative reaction under ultraviolet and ionizing irradiation.

Methods. Cerium dioxide nanoparticles with high antioxidant activity were obtained using laser ablation. Atomic force microscopy was used to characterize ablated cerium dioxide nanoparticles and cells incubated with cerium dioxide nanoparticles. The protective properties of cerium dioxide nanoparticles were studied after 0 (without incubation), 6and 24-hour incubation using the colorimetric MTT test method.

Results. Using laser ablation, cerium oxide nanoparticles with a maximum size of up to 50 nm were obtained. The resulting nanoparticles were incubated with BJ TERT cell lines for 6 and 24 hours. The samples were subjected to ultraviolet (UV) and ionizing irradiation in order to reveal the protective properties of CeO2 nanoparticles. Based on the results of the MTT test, it was found that incubation with cerium dioxide nanoparticles has a pronounced protective effect on the BJ TERT cell line. After UV irradiation, 6-hour and 24-hour incubation of cerium oxide nanoparticles with cell culture provides 15±5% and 20±5% more cell survival, respectively, than without particles. After ionizing radiation, the percentage of survival of cells incubated for 24 hours with cerium nanoparticles also increases by 20±5%.

Conclusion. This work shows that ablated cerium dioxide nanoparticles have a protective effect on healthy BJ TERT cells. The work shows that cerium oxide nanoparticles are promising antioxidants that can provide a protective effect for cell cultures from ultraviolet and ionizing radiation.
Kinetics and Mechanism of Liquid-Phase Interaction of Carbide Steels with a Steel Base
Authors: Narva V. K. , Eremeeva Zh. V. , Gomzhin V. V. , Volgina N. I.
Published: January 2024

Resume. To develop a mathematical model of the interaction of a carbide steel coating with a steel base under conditions of the formation of a liquid phase.

Methods. The average value of the transition zone was experimentally determined using a PMT-3 device. The size of the transition zone in the carbide steel layer was determined using a MAR-2 X-ray microanalyzer.

Results. A mathematical model of the interaction of a carbide steel coating with a steel base under conditions of liquid phase formation has been developed. It is established that the distribution of carbon in the transition zone of the carbide steel layer (δL) and the steel base (δS) is described by an exponential dependence, and the above technique allows to predict the size of the transition zone with high accuracy, which confirms the corollary of the theory that when applying a layer on a base with a lower carbon content, the width of the transition zone will be greater, and the speed of the melting of the base is less. properties of coatings made of carbide steels of various compositions. High adhesion strength of coatings to the substrate after vacuum sintering has been established (for carbide steel of 10% TiC, steel Cr6V3Mo 116 MPa; for carbide steel of 40% TiC, steel Cr6V3Mo 131 MPa; for carbide steel of 40% TiC, steel Cr12Mo 220 MPa), which in combination with their high physical-mechanical properties allow us to recommend the method of plasma spraying of coatings made of carbide steels for the restoration of worn surfaces of parts and tools for various purposes.

Conclusion. The developed mathematical model makes it possible to calculate the size of the intermediate layer, as well as the diffusion coefficients of carbon in the liquid phase and in the steel base.
The Potential of Batu City-Western Australia Partnership in the Fields of Agriculture and Livestock: Challenges and Opportunities
Authors: Prasetya Dion Maulana , Qomaria Nurul , Ardiyanti Devi , Habibah Putri Ulfa , Putri Adila , Hermayanis Irma
Published: January 2024

The objective of this essay is to assess the possibility of collaboration between Batu City and Western Australia in the field of Agriculture and Livestock. The author employed a qualitative research methodology to investigate the collaboration between Batu City and Western Australia. The study approach adopted was descriptive, focusing on providing a detailed account of the collaboration. The primary method of data gathering involved conducting interviews with government personnel from Batu City. Additionally, secondary material was gathered from reputable websites and periodicals, and subsequently examined within the concept of the Paradiplomacy. The researchers discovered a significant potential for collaboration between the two cities. Batu City excels in producing high-quality horticultural seeds that are exported to multiple countries. However, there is a drawback in the livestock sector due to the prevalence of diseases affecting animals. As a highly developed province, Western Australia has the capability to transfer technology to Batu City in order to enhance the quality and quantity of these two sectors. Regrettably, the collaboration's potential was limited to the exploratory stage due to the Batu City Government's subpar efforts in uploading the city profile. This hindered partners from fully recognizing the potential of Batu City. Hence, it is imperative to augment the human capital of the Batu City Government and enhance its systems and administration in order to effectively engage in paradiplomacy with overseas counterparts.
The Utilization of Information Technology for the Professional Development of Islamic Education Teachers in Indonesia
Authors: Ikhwan M. , Fuadi Muhammad , Mailizar Mailizar , Jannah Misbahul
Published: January 2024

The professional development of Islamic Religious Education (PAI) teachers is crucial to enhancing the quality of PAI learning in schools. One effective means to support their professional growth is through the utilization of technology as a learning medium and information source. This article aims to explore the use of technology by PAI teachers in their professional development, focusing on three key aspects: (1) The Importance of Integrating Technology in Teacher Professionalism; (2) Types and Functions of Technology Used by PAI Teachers; (3) Challenges Encountered by PAI Teachers in Advancing Professionalism through Technology. The research methodology used the qualitative method with the literature review approach, encompassing data collection and analysis from diverse sources such as journals, books, reports, and websites. The findings reveal that PAI teachers in Indonesia employ various technologies, including computers, laptops, smartphones, tablets, internet connectivity, social media platforms, applications, and software, for multiple purposes like information retrieval, communication, collaboration, content creation, presentation, and assessment of learning. The use of technology among PAI teachers yields several advantages, including the enhancement of knowledge, skills, motivation, creativity, networking opportunities, and learning resources. However, they face challenges related to limited infrastructure, access, costs, and support. Moreover, there's a lack of readiness, competence, and awareness regarding ethics and security among these educators. PAI teachers encounter difficulties, obstacles, and risks such as network disruptions, viruses, malware, spam, phishing, hacking, cyberbullying, and plagiarism. The challenges of utilizing technology for teacher professional development encompass skills, attitudes, infrastructure, and ethical considerations. Therefore, PAI teachers must possess adequate competence and readiness to integrate technology into their professional development.
Effects of Mannyeon-hwan on Acetic Acid-induced Colitis in Rats
Authors: Kong Won-ho , Kim Bum-hoi , Kim Won-ill
Published: January 2024

Objectives: This study is designed to verify the effects of Mannyeon-hwan (MNH) on acetic acid-induced colitis in rats.Methods: Colitis was induced in male Sprague-Dawley rats weighing approximately 250 g by injecting acetic acid through the anus. The rats were classified into four groups: normal group, acetic acid (AA) group, AA+MNH (L) (low concentration) group, and AA+MNH (H) (high concentration) group. The body weight, visual evaluation of the colonic mucosa, anatomical histological changes, and changes in the expression of cytokines in the colon tissue were compared and analyzed.Results: Compared with the normal group, weight loss was observed in mice induced with colitis. Compared with the AA group, weight loss recovery occurred in the AA+MNH (L) and AA+MNH (H) groups, and significant changes were observed after the sixth day. In the visual evaluation of the colonic mucosa, a significant decrease in damage indicators was observed in the AA+MNH (L) and AA+MNH (H) groups compared with the AA group. In terms of anatomical histological changes and changes in the expression of tumor necrosis factor-α and interleukin-6 in colon tissue, a significant decrease was observed in the AA+MNH (L) and AA+MNH (H) groups compared with the AA group. A more pronounced decrease was observed in the AA+MNH (H) group compared with the AA+MNH (L) group.Conclusion: The effects of MNH on colitis were confirmed through research. MNH can be used as a first-line treatment for patients complaining of colitis who visit oriental medicine clinics.
A Review of Domestic Research on Traditional Korean Medicine for Chronic Prostatitis in Clinical Research Papers
Authors: Lee Ji-yoon , Jo On-you , Park Sang-min , Choi Sae-rom , Shin Jae-wook , Baek Jee-hoon , Lee Eun-jee
Published: January 2024

Objectives: This study was conducted to examine the current status of traditional Korean medicine studies on chronic prostatitis in Korea, identify deficiencies, and suggest future medicine research methods to lay the foundation for traditional Korean medicine treatment.Methods: All domestic clinical research papers on the traditional Korean treatment of chronic prostatitis were selected from the literature published until October 2023 in three domestic databases. A total of 13 selected research data were classified into clinical research papers.Results: In clinical research papers, the basis for the diagnosis of cases was clinical symptoms through medical history listening and diagnosis through past visits to hospitals. The average treatment period was 7 weeks, and the duration of treatment was not significantly affected by the duration of the disease. The most widely used Korean medicine treatment intervention was herbal medicine.Conclusions: This study included all domestic clinical research papers on chronic prostatitis to identify research trends in the Korean oriental medicine community. Based on this, it is meaningful to confirm areas that need to be supplemented in future research plans.
Recent Research Trends in the Pharmacological Effects of Zingiber officinale in Korea
Authors: Hwang Bo Saem-Gyeol , Roh Jong Seong
Published: January 2024

Objectives: This study aims to analyze recent research on the pharmacological effects of Zingiber officinale.Methods: We searched for papers from databases such as ScienceON, RISS, DBPia, and NaNet. The papers were classified according to pharmacological effects, and the selected studies were analyzed.Results: Six studies were finally included in the study. 1. Four studies mainly focused on the effects of anti-inflammation using in vitro or in vivo experiments. 2. Two studies mainly focused on the effects of antioxidants using in vitro experiments. 3. Other pharmacological effects, including improvement of gastrointestinal function, inhibition of body temperature reduction, and anti-aging, were investigated using in vitro or in vivo studies.Conclusion: This study shows that Z. officinale has several pharmacological effects, including anti-inflammation and antioxidant.
Orally Administered Korean Herbal Medicine Medications of Randomized Controlled Trials Published in the Journal of Korean Medicine and Related Journals: A Narrative Analysis using CONSORT-CHM 2017
Authors: Moon Se-hun , Jo Jung-ho , Choi Seung-kwan , Han Yun-hee , Woo Hyeon-jun , Jeon Byeong-hyeon , Ha Won-bae , Lee Jung-han
Published: January 2024

Objectives: This study aims to explore the current usage status of orally administered Korean herbal medicine in randomized controlled trials (RCTs) published in the Journal of Korean Medicine and member journals using the CONSORT-Chinese HerbalMedicine Formulas 2017 (CONSORT-CHM 2017) checklist. Methods: We searched the OASIS, RISS, and KMBASE archives as well as the websites of the Journal of Korean Medicine and 45 member journals to identify RCTs that used herbal interventions. Two independent researchers searched and categorized the RCTs and performed a quantitative evaluation by journal, study design, and target disease, as well as qualitative evaluation of the literature using CONSORT-CHM 2017.Results: After the search, 66 articles were selected. The quantitative evaluation resulted in 13 articles (19.6%) that were published in the Journal of Korean Medicine and 12 articles (18.1%) in the Journal of Internal Korean Medicine. In terms of study design, 62 articles (93.9%) were parallel, 4 articles (6%) were crossover, and 2-arm parallel study designs were the most common in 45 articles (68.2%). In terms of the study participants, physiological characteristics and mechanisms in healthy individuals were the most common in 21 studies (31.8%) and obesity in 9 studies (13.6%). In terms of assessing completeness in the CONSORT-CHM 2017 items, 29 articles were rated high, 31 were rated moderate, and 6 were rated low. Items 4a, 6a, and 7a had low reporting rates (≤ 30%), while items 2a, 2b, and 12a were completely reported in all studies.Conclusion: Future RCTs using orally administered Korean herbal medicine need to be reported completely, and the CONSORT-CHM 2017 checklist can be a helpful tool for this purpose.
Study of the Effect and Underlying Mechanism of Enzyme-Treated Garlic Extract on a Lipopolysaccharide-Induced Acute Colitis Model
Authors: Kim Min Ju , Shin Mi-Rae , Choi Hak Joo , Roh Seong-Soo
Published: January 2024

Objective: This study aims to explore the pharmacological effects and mechanisms of enzyme (Viscozyme)-treated garlic extract (EG) in an animal model of acute enteritis induced by lipopolysaccharide (LPS).Methods: The experiment included four subgroups: normal, control, EG200 (treated with 200 mg/kg EG), and EG400 (treated with 400 mg/kg EG). Drug administration lasted 3 days, followed by the induction of acute enteritis in all groups (except normal) through the intraperitoneal administration of 20 mg/kg of LPS 1 h after the last oral dose. Autopsy was conducted 24 h later to collect serum and colon tissue. Serum was analyzed for reactive oxygen species (ROS) and C-reactive protein (CRP), while Western blotting was performed on the colon tissue.Results: After analyzing the ROS and CRP levels in serum, the EG treatment group exhibited a significant decrease compared with the control group. The EG treatment group exhibited a significant decrease in the activation of the mitogen-activated protein kinases (MAPKs)/nuclear factor-kappa B p65 (NF-κB) pathway compared with the control group. EG administration significantly regulated apoptosis-related factors, including B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X, cysteine aspartyl-specific protease-3, and cytochrome C.Conclusions: EG treatment in mice with LPS-induced acute colitis reduced the ROS and CRP levels, suppressed the MAPKs/NF-κB pathway in the colon, and effectively alleviated acute enteritis by modulating apoptosis-related factors. Based on these findings, EG emerges as a promising candidate for the prevention and treatment of acute colitis, showing its potential therapeutic efficacy in this experimental model.
A Discussion on Three Different Issues Between Huangdi Neijing 黃帝內經 and Yixuexinwu 醫學心悟 Regarding the 19 Mechanisms of Disease (病機十九條)
Authors: Jeon Chan-yong
Published: January 2024

Objective: The 19 Mechanisms of Disease were first described in Huangdi Neijing. When examining Yixuexinwu, three descriptions that were different from Huangdi Neijing were found.Methods and Results: After examining the two books, three differences in the description of the 19 Mechanisms of Disease were discovered: 1) The upper and lower locations of dyspnea (喘症) are reversed. 2) The ratio of provisions for “fire (火)” and “cold (寒)” is different. 3) The organ affiliation for pain is different.Conclusion: 1) The upper and lower locations of dyspnea (喘症) are reversed. : Regarding external contraction dyspnea (外感喘), Yixuexinwu used the disease of the upper location (lung 上, 肺) in the same way as in Huangdi Neijing. In terms of internal damage (內傷喘), it was separately classified as a disease of the lower location (kidney 下, 腎). 2) The ratio of provisions for “fire (火)” and “cold (寒)” is different. : Arithmetically, if you round off the number after calculating the fraction, the difference between the two ratios becomes the same. Theoretically, five provisions of “fire” are replaced by four provisions of “heat (熱)”, and the difference in ratios is exactly the same. Empirically, it emphasizes that there are more illnesses from fire and heat than from cold. 3) The organ affiliation for pain is different. : Huangdi Neijing described general inflammatory pain, while the Yixuexinwu described only stress-related abdominal pain (肝木乘脾腹痛).
Korean Medicine Treatment for a Patient with Post-COVID-19 Pulmonary Fibrosis: A Case Report
Authors: Shin Jeong-Won , Park Jiwon , Chin Su-Hyun , Kim Kwan-Il , Jung Hee-Jae , Lee Beom-Joon
Published: January 2024

Background: Post-COVID-19 pulmonary fibrosis (PCPF) is a common complication in severe COVID-19 cases, often associated with acute respiratory distress syndrome or mechanical ventilation. Patients with PCPF frequently experience a decline in their quality of life due to persistent COVID-19 sequelae, including cough and chest pain. However, there is currently no established standard treatment, and the efficacy of existing medications remains uncertain.Case Report: A 65-year-old female patient presenting with cough, dyspnea, chest pain, and fatigue due to PCPF received Korean medicine treatment for 25 days. Symptom evaluation utilized the modified Medical Research Council scale, the Leicester Cough Questionnaire, and the Numeral Rating Scale. Quality of life and functional status were assessed using the Post-COVID-19 Functional Status and the EuroQol 5-Dimensional 5-Level. The extent of pulmonary fibrosis was assessed by comparing chest computed tomography (chest CT) scans before and after hospitalization. Following treatment, the patient demonstrated clinically meaningful improvement in clinical symptoms, enhanced quality of life, and decreased fibrotic lesions on CT scans.Conclusion: This case report suggests that Korean medicine treatment may be effective in improving clinical symptoms, such as cough and dyspnea caused by PCPF, while also enhancing post-COVID-19 quality of life and ameliorating pulmonary fibrotic lesions.
Combined Effects of Gami-sipjeondaebo-tang Administration, Acupuncture, and Wet Dressing in a Patient with Grade 4 Pressure Ulcer: A Case Report
Authors: Kang Sunny , Song Ju-hwan , Ji Sang-ho , Kim Cheol-hyun , Lee Sang-kwan
Published: January 2024

Introduction: Pressure ulcers, often found in patients with mobility issues, particularly elderly patients, are increasing in prevalence. Their treatment is complex, with recovery more challenging in advanced stages, and certain factors can delay healing.Case Presentation: An 87-year-old male developed a grade Ⅳ pressure ulcer on his left greater trochanter following lumbar fractures and subsequent percutaneous vertebroplasty in 2021. Despite potential surgical recommendations, his treatment consisted of daily wet dressings, acupuncture from July 2021 to February 2022, and Gami-sipjeondaebo-tang beginning August 2021. The ulcer, initially measuring 6 cm×6 cm and showing a red wound without necrosis, healed completely and showed no signs of recurrence as of August 2023.Conclusion: A grade IV pressure ulcer was effectively treated using wet dressing, acupuncture, and Gami-sipjeondaebo-tang, demonstrating no recurrence over a 1.5-year period.
A Case Report of Anti-NMDA Receptor Encephalitis with Ovarian Teratoma Improved by Korean Medicine
Authors: Nam Irang , Kim Min-hwa , Kim Mariah , Ku Ki-beom , Lee Se-yeon , Kim So-yeon , Park So-jung , Choi Jun-yong , Han Chang-woo , Hong Jin-woo , Kang Ji-won , Lee In
Published: January 2024

Objectives: This study reports on the improvement of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis with ovarian teratoma after Korean medicine treatment.Methods: A patient was treated with Korean medicine treatments, such as acupuncture and herbal medications (Gami-ondam-tang and Samulanshin-tang-gamibang). The patient’s improvement was evaluated using manual muscle testing (MMT), the Mini-Mental State Exam-Korea (MMSE-K), the modified Barthel index (MBI), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE).Results: After using Korean medicine treatments, the patient’s MMT, MMSE-K, and MBI scores increased, and the CASE score decreased.Conclusion: This case suggests that Korean medicine can be effective in treating the symptoms of anti-NMDA receptor encephalitis.
A Comparative Study of Residential Mobility of Elderly Households before and after COVID-19
Authors:   Residential Environment Institute Of Korea, Yang Ji Soo , Kim Ho Cheol
Published: January 2024

This study aimed to analyze changes in the housing mobility patterns of elderly households nationwide before and after the COVID-19 pandemic, as well as the determinants influencing their intention to move, using microdata from Korea housing survey. The analysis utilized binary logistic regression, considering the characteristics of the dependent variable. The main findings of this study are as follows. First, there were significant differences in the determinants influencing the elderly households’ intention to move before and after COVID-19. The determinants include the number of household members, monthly average total disposable income and residential environment satisfaction. Second, after COVID-19, elderly households tend to have an increased preference for urban areas with relatively good residential environments. Third, a polarization in housing mobility between urban and non-urban areas was observed among the elderly after COVID-19. This study aimed to interpret the implications and motivations of residential mobility choices through a micro-level analysis of the residential mobility of the elderly, which has been discussed collectively due to the small number of cases. This study also confirmed that in order to ensure housing stability for the elderly, senior employment policies should be implemented concurrently. According to the findings, it is it is necessary to implement localized senior housing alternatives that reflect the changing residential mobility needs of the elderly. Furthermore, the reconfiguration of urban infrastructure to accommodate the aging population should be prioritized in elderly housing policies, in line with the pace of population aging.
The　Effect of Housing Value Factors of Korean University Students and Foreign Students on Housing Satisfaction: Comparative analysis before and after COVID-19
Authors:   Residential Environment Institute Of Korea, Koh Eun Ha , Kim Seok Tae
Published: January 2024

The purpose of this study is to compare and analyze the effect of housing value factors of Korean and foreign students on housing satisfaction before and after COVID-19. The relationship between housing value and housing satisfaction is important in choosing one-room housing for Dongguk University students living near Dongguk University. SPSS statistical data were analyzed through surveys from January 2019 to December 2020. These studies show that Dongguk University students, especially those living in Jangchung-dong, Jung-gu, Seoul, are aware of the value of typical one-room residents and problems with one-room housing, which is meaningful in predicting more suitable demand for startups and providing basic data. It is more appropriate to establish a one-room housing and one-room housing plan. This study will illuminate the housing value and housing satisfaction factors of college students living in Seoul.
A study on architectural design information processing model using artificial intelligence (AI)
Authors:   Residential Environment Institute Of Korea, Choi Du ho
Published: January 2024

Recently, there is a lot of discussion in the architectural world about the impact that artificial intelligence image generation models will have on architectural design. Artificial intelligence uses information processing theory to analyze and model human cognitive abilities. According to information processing theory, architectural design is an information processing activity that establishes reasonable concepts to solve spatial problems and processes visual and conceptual information that corresponds to them. In this study, the five information processing processes of Akin's (1986) information processing model, DIPS (design information processing system), 'Information acquisition', 'Information representation', 'Information projection', 'Information confirmation', and 'Regulation of control'. The characteristics of architectural design thinking types, ‘convergent thinking’, ‘divergent thinking’, and ‘analogical thinking’ were examined. Through this, I identified the characteristics of representative design-related artificial intelligence NLP, GAN, and DNN and proposed an architectural design information processing model using artificial intelligence. The purpose of this paper is to examine the architectural design information processing model and compare the characteristics of the thinking style that occurs in the process with the characteristics of the artificial intelligence model to analyze the possibility of using artificial intelligence in architectural design and to provide architectural design information using artificial intelligence. The goal is to propose a processing model.
A rare clinical case of a labyrinthine lesion: an endolymphatic sac tumor
Authors: Zhorina A. S. , Voronov V. A. , Pustovoy S. V. , Demidenko D. Yu. , Zhorina O. M.
Published: January 2024

Endolymphatic sac tumors are rare neoplasms originating from the endolymphatic epithelium of the intraosseous part of the endolymphatic duct and sac, typically characterized by slow growth and local destructive changes. We present a case of an endolymphatic sac tumor in a 28-year-old man who consulted an otoneurologist with complaints of progressive hearing loss and dizziness attacks and was referred for a CT scan of the temporal bones and MRI of the inner ear with delayed contrast enhancement. The data of otoneurological and radiological examinations before and after surgical treatment and the results of surgical treatment with histological verification of the tumor are presented. The objective of this case presentation is to demonstrate the usefulness of CT and MRI methods in detecting an endolymphatic sac tumor, to compare the results of otoneurological and radiological examinations and intraoperative and histological data followed by surgery. Radiological examination revealed a neoplasm of the right temporal bone with typical imaging characteristics of endolymphatic sac tumor. Surgery was performed, the mass was removed completely, and the endolymphatic sac tumor was histologically verified. Radiologic presentation includes a typically located area of bone destruction in the petrous part of the temporal bone in the area of the vestibular aqueduct, possibly with the spread of the tumor into the cerebellopontine angle, with a heterogeneous structure, with uneven contrast enhancement. Due to the rarity of this pathology, diagnosis in the early stages is often difficult, and for the correct interpretation of radiologic findings in patients with hearing loss and dizziness, knowledge of the normal anatomy of the temporal bone and awareness of rare variants of its lesions are of key importance. Timely examination of patients with suspected temporal bone lesions and correct diagnosis are the key to successful treatment and maintaining the quality of life in this group of patients.
Brain microstructure mapping in major depressive disorder: a pilot MR study
Authors: Abramova V. D. , Petrovskiy E. D. , Savelov А. А. , Mazhirina K. G. , Korostyshevskaya A. M.
Published: January 2024

INTRODUCTION: Major depressive disorder is a common mental health disorder. Alterations in cortical structures have been identified in this disease, but findings have been variable and inconsistent. Previous studies have illustrated that the cingulate and prefrontal gyrus, along with the amygdala, are involved in emotional processing and the development of abnormal emotional responses in depression.OBJECTIVE: Our research aims to investigate the neurological structural differences and alterations in ACC, bilateral amygdala, and dmPFC regions in patients with MDD using quantitative MRI (MPF and Diffusion parameters mapping (DPM), including diffusion kurtosis).MATERIALS AND METHODS: In this study, we utilized advanced quantitative MRI techniques, specifically Diffusion Tensor Imaging, Diffusion Kurtosis Imaging, and Мacromolecular Proton Fraction Mapping, to investigate microstructural differences and alterations in the specific regions in patients diagnosed with major depressive disorder. RESULTS: Our findings revealed no significant interaction between Мacromolecular proton fraction Mapping with depressive disorder. However, patients with major depressive disorder exhibited a statistically significant increase in apparent mean, axial and radial diffusivity (F=6.3, p=0.01, F=5.0, p=0.03, F=7.08, p=0.01, respectively) in the bilateral amygdala compared to healthy controls, as well as in mean and radial diffusivity in the anterior cingulate cortex (F=5.61, p=0.02, F=7.08, p=0.01, respectively).DISCUSSION: These findings suggest that altered molecular diffusion characteristics in the amygdala and the anterior cingulate cortex may be specifically associated with major depressive disorder.CONCLUSIONS: The importance of using new quantitative MRI methods to assess structural changes at the molecular level in the brain is shown, which, ultimately, expands the fundamental understanding of the pathophysiology of depression.
Texture analysis of CT- and MR-Images in the differential diagnosis of renal cell carcinoma: a review
Authors: Karelskaya N. A. , Gruzdev I. S. , Raguzina V. Yu. , Karmazanovsky G. G.
Published: January 2024

INTRODUCTION: Renal cell carcinoma (RCC) is a heterogeneous group of diseases. The most common type of RCC is clear cell RCC. Tumor biopsy is the «gold» standard for verifying the diagnosis, however, it can be unsatisfactory due to the characteristic heterogeneity of the RCC structure. Non-invasive diagnostic methods — computed tomography and magnetic resonance imaging — in combination with the use of texture analysis can potentially provide a large amount of information about the structure of the kidney tumor and the presumed degree of its differentiation (grade).OBJECTIVE: Тo analyze publications devoted to texture analysis in RCC, the possibilities and prospects of using this method to increase the information content of CT and MR studies.MATERIALS AND METHODS: Our review presents data obtained from available sources PubMed, Scopus and Web of Science, published up to March 2022 inclusive, found using the keywords: renal cell carcinoma, CT, MRI, texture analysis, radiomics in Russian and English.RESULTS: The literature review describes the methods of texture analysis: selection of the region of interest, modality and contrast phase of the study, diagnostic aim. Based on the results of published scientific papers, the authors conclude that the use of texture analysis makes it possible to predict the grade of RCC with high sensitivity, specificity and accuracy, as well as to make a differential diagnosis of RCC with other kidney neoplasias, primarily lipid poor angiomyolipomas.CONCLUSION: The use of texture analysis based on published materials is extremely promising for non-invasive prediction of RCC grade and its differential diagnosis, however, the difference in methods and the lack of standardization of texture analysis requires additional research.
Assessment of pulmonary fibrosis severity at autopsy in patients after COVID-19: comparison with quantitative CT scan data in the acute phase of the disease
Authors: Zakharova A. V. , Gvozdetskiy A. N. , Alekseev D. A. , Pozdnyakov A. V.
Published: January 2024

INTRODUCTION: After the COVID-19 pandemic, there is increasing evidence that many patients show fibrous changes in lung tissue accompanied by functional lung disorders. Objective data on the histopathogenesis of such changes is still insufficient. Prospective studies are required to fully assess the consequences of these clinical manifestations.OBJECTIVE: Evaluation of the capabilities of digital processing of histological preparations of lung tissue and their comparison with quantitative CT data of lung patients in the acute phase of COVID-19.MATERIALS AND METHODS: The study included data from patients after COVID-19 (7 women and 3 men aged 47 to 93 years) who died after the acute phase of COVID-19 from extrapulmonary causes. The control group included data from 7 people (5 women and 2 men aged 35 to 93 years) who died shortly after hospitalization from extrapulmonary causes (myocardial infarction or acute cerebral stroke), with no signs of lung diseases, including autopsy results. Digital processing of histological preparations of lung tissue obtained during autopsy was carried out, and their comparison with the results of quantitative semi-automatic processing of CT data.Statistics. Beta regression (mgcv library) was used. The model was characterized by a pseudodetermination coefficient R2. The association was considered statistically significant at p<0.05.RESULTS: A reliable dependence of the severity of fibrous changes in histological samples on the results of quantitative analysis of CT images of patients in the acute period of COVID-19 was demonstrated.DISCUSSION: Extrapolation of lung autopsy data through quantitative CT assessment is one of the ways to pre-diagnose and identify groups of patients who require specific treatment of post-COVID-19 pulmonary fibrosis.CONCLUSION. Computerized digital processing of histological images made it possible to correctly compare the histopathological examination data with the CT picture in COVID-19, which could potentially have a prognostic value in the search for more effective treatment strategies.
Разработка схемы взаимодействия участников строительного процесса с целью получения достоверной сметной стоимости на этапе проведения государственной экспертизы проектной документации с помощью технологий информационного моделирования
Authors: Серёгина Наталья Юрьевна , Сербин Сергей Андреевич , Фомин Никита Игоревич
Published: January 2024

В работе были исследованы организационные возмож­ности разрешения проблемы несоответствия сметной и фактической стоимости объектов капитального строительства за счет разделения процесса проведения государственной экспертизы на два организационных этапа: проверки проектных решений объекта капитального строительства и оценки достоверности сметной стоимости. Авторами была проведена экспертная оценка текущего количества объектов капитального строительства на основании опроса экспертной группы, в ходе которой было выявлено, что в среднем 59,5 % объектов капитального строительства в год, финансируемых из государственного и муниципального бюджета, имеют более 2 % расхождения между сметной стоимостью на этапе архитектурно-строительного проектирования и фактической стоимостью строительства. Была проведена оценка трудозатрат специалистов Министерства строительства и развития инфраструктуры Свердловской области при необходимости корректировки бюджетных программ. Была сформирована действующая схема взаимодействия участников строительного процесса, на основании которой выявлены проблемные участки, на которых происходит информационный разрыв между детализацией цифровой информационной модели, необходимой для экспертизы проектных решений и для оценки достоверности сметной стоимости объекта капитального строительства. Авторами статьи была разработана и предложена схема взаимодействия с применением технологий информационного моделирования для получения сметной стоимости объектов капитального строительства, исключающая информационный разрыв за счет разделения процесса государственной экспертизы на два этапа, и рассчитана разница временных издержек процессов обеих схем, которая составляет 51 день. Было предложено внесение корректировок в законодательство с утверждением проведения процесса экспертизы в два этапа, а также утверждение единых требований к цифровым информационным моделям для реализации предложенной схемы и внедрению технологий информационного моделирования в процесс государственной экспертизы.
Формирование факторов риска строительства объектов атомной энергии в странах Латинской Америки
Authors: Гусев Юрий Сергеевич
Published: January 2024

Анализ развития международного рынка атомно-энергетического строительства позволяет выявить и оценить проблематику экономической надежности и рисков при реализации международных проектов Государственной корпорации (ГК) Росатом. ГК Росатом на протяжении многих лет последовательно ведет международное сотрудничество и сопровождение различных проектов за рубежом, развитие компетенций компании и мирного атома в других странах. Основные направления в области международного сотрудничества: сопровождение и реализация АЭС, а также развитие нового перспективного направления развития международного бизнеса по сооружению центров ядерных исследований и технологий. В статье рассмотрен пример реализации центра ядерных исследований и технологий в многонациональном государстве Боливия. Центр ядерных исследований и технологий — сложный инновационный технический проект, воплотивший в себе комплекс ядерных технологий для развития на уровне государства самых разных областей (исследований, развития сельского хозяйства, повышения уровня медицины, экспертиз и др.). Проект реализуется в рамках Соглашения между Правительством Российской Федерации и Правительством Боливии. Это также позволяет в дальнейшем получить новый контракт на рынке стран Латинской Америки. Рассмотрены примеры международного сотрудничества по направлению международной деятельности госкорпорации Росатом. Выполнен экспертный анализ рисков проекта в Боливии. Таким образом, в перспективе в Латинской Америке предстоит реализация нескольких крупных пилотных инновационных высокотехнологичных проектов, а также дальнейшая реализация аналогичных проектов в других частях мира (Африка и Азия).
Entre o local e o global: as redes de parcerias e a constituição da visibilidade religiosa na Igreja da Comunidade Metropolitana do Rio de Janeiro (ICM-Rio)
Authors: Azevedo Pedro Costa
Published: January 2024

O presente artigo analisa a circulação de representantes religiosos, imagens e ideias ligadas à Igreja da Comunidade Metropolitana (ICM) nos EUA, com maior enfoque nas atividades desenvolvidas na filial carioca, no período de 2019. Busco mostrar etnograficamente a manutenção de relações transnacionais que possibilitam a criação de uma agenda de medidas e estratégias comuns de atuação religiosa. Inicialmente o intercâmbio entre o local e o global será mobilizado através da ida das lideranças da ICM-Rio de Janeiro à Conferência Geral da Universal Fellowship of Metropolitan Community Churches (UFMCC), sediada na Flórida (EUA). Em um segundo momento, abordarei a recepção da moderadora geral da UFMCC, cargo primaz da instituição religiosa, à ICM-Rio. Além desses eventos, os cultos dominicais, material digital e outras atividades também foram acionados para entender a constituição de uma trajetória institucional compartilhada entre a igreja local e as atuações e representações da ICM em nível global. Foi possível compreender um ativismo político na ICM-Rio atrelado às questões de gênero, sexualidade e étnico-raciais, através do enfrentamento ao HIV-Aids e de práticas antirracistas. Concluo que essa atuação local estabelece redes de parcerias que possibilitam a legitimidade e a visibilidade da instituição religiosa no espaço público.
Testing multifactor asset pricing models in the stock market
Authors: Khanh Pham Dan , Duong Le Quy , Anh Pham Vu
Published: January 2024

lthough the superiority of Fama-French (FF) five-factor model in capturing the United States (US) equity returns, this model performs poorly in other stock markets (Fama & French, 2017). Using the monthly data of nearly 600 Vietnamese published firms from 2008 to 2022, the primary purpose of this paper is to analyze and examine the performance of four famous multifactor asset pricing models: the capital asset pricing model (CAPM), the Carhart four factor model, and the FF three-factor and five-factor models. We document the preference for the Carhart four-factor model over other models in producing a precise description to Vietnamese stock returns. The CAPM cannot give a reasonable explanation to the variation of Vietnamese stock returns, implying that market risk only accounts for a small proportion of the risk of holding Vietnamese stocks. Furthermore, adding the profitability and investment factors does not improve the explanatory power of asset pricing models in Vietnam, inconsistent with the result reported in the US stock market (Fama & French, 2015, 2020).
Structuring and determining the influence of stakeholders on the innovation ecosystem
Authors: Ostapenko Viktoriia , Tyshchenko Viktoriia , Rats Olha , Brusentseva Olga
Published: January 2024

In this paper, criteria for the distribution of stakeholders of the innovation ecosystem (IE), such as subsystems, functional features and positions, are formed. Stakeholder matrices and maps have been constructed for monitoring and identifying trends in changes in the rank of stakeholders in the innovation ecosystem. According to the conducted calculations, in addition to quantitative calculations, their qualitative assessments were provided according to linguistic sets. In the process of research, the method of constructing membership functions of discrete fuzzy sets, as cognitive modeling, was used to determine the influence of cause-and-effect relationships. The elements of the matrix of mutual influences of the cognitive map were expertly formed in the modeling process. The purpose of the paper is to identify the stakeholders of the innovation ecosystem, structure them by subsystem categories, sphere and level of influence, to model the interaction of stakeholders within the innovation ecosystem. Understanding the systemic roles and interactions of stakeholders is critical to gaining a more accurate and detailed view of their contributions. A purposeful approach to building an innovative ecosystem allows you to form stakeholders to ensure their effective interaction.
SmartTA: A Block chain and Auto-ml Approach for Game-based Teaching Guidance to improve student’s performance
Authors: Liang Guo
Published: January 2024

Yue Lei was once involved in the literature review writing of this
article and was responsible for ensuring the correctness of the English
writing. However, during the process of revising the article, Yue Lei
and Guo Liang had disagreements and conflicts regarding how to modify
the content. Therefore, Yue Lei is no longer involved in the editing and
publication of this article and bears no responsibility for the content
published. As of today, Guo Liang is the sole author of this article.
Please be informed. January 20, 2024.
Multi-GNSS Robot
Authors: Bhatt Narendra , Singh Mandeep
Published: January 2024

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ICESat-2 Onboard Flight Receiver Algorithms: On-orbit Parameter Updates the Impact on Science Driven Observations
Authors: Magruder Lori A. , Reese Ann R , Gibbons Aimée , Dietrich James T. , Neumann Thomas A
Published: January 2024

The ICESat-2 (Ice, Cloud and Land Elevation Satellite-2) photon-counting
laser altimeter technology required the design and development of very
sophisticated onboard algorithms to collect, store and downlink the
observations. These algorithms utilize both software and hardware
solutions for meeting data volume requirements and optimizing the
science achievable via ICESat-2 measurements. Careful planning and
dedicated development were accomplished during the pre-launch phase of
the mission in preparation for the 2018 launch. Once on-orbit all of the
systems and subsystems were evaluated for performance, including the
receiver algorithms, to ensure compliance with mission standards and
satisfy the mission science objectives. As the mission has progressed
and the instrument performance and data volumes were better understood,
there have been several opportunities to enhance ICESat-2’s
contributions to earth observation science initiated by NASA and the
ICESat-2 science community. We highlight multiple updates to the flight
receiver algorithms, the onboard software for signal processing, that
have extended ICESat-2’s data capabilities and allowed for advanced
science applications beyond the original mission objectives.