bluuebunny/crossref_metadata_2025 huggingface dataset:
“DEVELOPMENT AND CHARACTERIZATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) FOR BAUHINIA VARIEGATA LEAF EXTRACT”
Authors: Chandrakar Nidhi , Das Dr Pulak , Mishra Dr.Mohit , Karley Dr.Durgeshwar , Pandey Dr Akanksha
Published: January 2024

This study aimed to formulate and characterize a Self-Microemulsifying Drug Delivery System (SMEDDS) for Bauhinia variegata leaves, a traditional medicinal plant renowned for its anti-tumor properties, in order to enhance the solubility and bioavailability of its bioactive compounds. Bauhinia variegate leaves were collected locally (Amity university ).The successful formulation and characterization of the SMEDDS for Bauhinia variegata not only contribute to advancing drug delivery technologies for traditional medicines but also pave the way for further research into practical applications in the pharmaceutical and herbal medicine industries. This study provides valuable insights for the development of innovative and effective delivery systems for bioactive compounds derived from traditional medicinal plants. Developing a self-microemulsifying drug delivery system (SMEDDS) for an ethanol extract from Bauhinia Variegate leaves involves creating a formulation that can spontaneously form a stable microemulsion when introduced to aqueous media, such as the gastrointestinal fluids. The use of a ternary phase diagram can help optimize the proportions of the key components in the formulation. SMEDDS are described as isotropic mixtures of herbal or synthetic oils, solid or liquid surfactants, or instead, one or greater hydrophilic solvents and co-solvents/surfactants that have a completely unique ability of forming satisfactory oil-in-water (o/w) microemulsions upon mild agitation followed by way of dilution in aqueous media, including GI fluids
In vitro Anti-malarial Activity of Rhizome Extracts of Curcuma species
Authors: Donipati Prasanthi , Harasreeramulu Dr.S. , Donipati Prasanna Jyothi
Published: January 2024

Anopheles mosquitoes carry the deadly parasite illness malaria, which kills thousands of people annually in many tropical and subtropical areas. This study set out to evaluate the effectiveness of chloroquine in treating Curcuma species malaria caused by Plasmodium vivax. In this investigation, the malaria pathogen Plasmodium vivax was employed. In an incubator with 5% CO2 and 37°C, parasitemia was cultivated in RPMI 1640 culture media supplemented with 10% human serum and 2µg/ml of gentamycin. In order to evaluate plant extracts' ability to combat malaria, we employed the susceptibility micro assay method. Significant parasitaemia inhibitions were demonstrated by ethanolic extracts of Curcuma longa, Hedychium coronarium, and Curcuma caesia against blood stage chloroquine-resistant P. vivax, with low cytotoxic effects to parasitaemia cells in vitro. These inhibitions ranged from 5.8-75.6%, 2.2-29%, and 2-29.8%. The growth of P. vivax, which is resistant to chloroquine, was effectively inhibited by extracts derived from six different plant species. The results supported the fractionation of these plants using a bioassay to identify strong anti-malarial chemicals or to create standardised extracts that could strengthen the anti-malarial impact in vitro
MEMAHAMI KONSEP MEDITASI DALAM KAJIAN SUTTA-SUTTA DALAM SUTTAPIṬAKA
Authors: Fendy Fendy , Surya Julia , Angela Shelfia , Suyati  , Lie Nie
Published: January 2024

This article aims to explain the understanding of meditation, which is useful for achieving a state of perfect mental health, peace and tranquility. This is because not all have a complete understanding of meditation, on the contrary, the diversity of types of meditation has resulted in many perspectives on meditation, some of which are contrary to Buddhist teachings, such as meditation to gain wealth, attractive appearance, or supernatural powers. This research uses literature and literature review methods. Literature review with reference review, review of literature publications by previous researchers related to the topic to be researched. The author not only collects theories but various reference sources including journals, Buddhist scriptures and books. From the literature search, the discussion includes: types of meditation to train the mind, conditions that support meditation, the benefits of meditation, samatha bhavana and vipassana bhavana meditation practice, and also current meditation practices, as well as the implications of meditation practice for householders in everyday life as more and more the urgent need to be able to organize oneself better in facing various roles in the family, work and environment.
Developing Training Courses about Spiritual Leadership in Higher Education in Thailand: Critical Review
Authors:   Korea Association for Public Value, Chongyan Zhang Chongyan Zhang
Published: January 2024

Purpose: Spiritual leadership launched into a significant topic in higher education globally; Thailand also desires to make positive social change sustainably in the World, the national higher education system is friendly identifying to a kind of leadership with spiritual growth, positive transformation, sustainability; however, the spiritual leadership is such one the higher education institutions in Thailand would like to search.
Method: The study was a critical review; in literature searching, there were keywords such as spiritual leadership, higher education, curriculum, and Thailand. Then, the researcher synthesizes the pieces of literature to develop the critical reviews under compared analysis (diverse perspectives, advantages, and disadvantages); however, all documental resources were searched from qualified engines, such as Google Scholar, Research Gate, and online libraries.
Results: The critical review found concepts of spiritual leadership with different perspectives in religion, business and higher education; then, the critical review also briefly introduced higher education in Thailand and why its higher education needs spiritual leadership and related training courses; however, the critical review disclosed the six types of training curriculums in developing spiritual leadership and general advantages and disadvantages in the training courses; finally, the researcher provided potential implications according to the major findings in the literature review, it may contribute practical suggestions to develop spiritual leadership in higher education in Thailand. Regarding the above necessary for developing spiritual leadership in higher education in Thailand, the researcher aimed to conduct a critical review, to fiful related theories in spiritual leadership concepts, what types of curriculums can assist spiritual leadership, what advantages and disadvantages in the curriculums, and why spiritual leadership suitably develop in Thailand.
Conclusion: In conclusion, the study disclosed spiritual leadership there were different perspectives on its concepts; however, spiritual leadership in higher education refined as leadership encourages personal growth, positive transformation, and sustainability for individuals; then, the study found six types of training curriculums suitable for developing spiritual leadership in higher education in Thailand; according to Thailand's details in higher education and major findings, the researcher suggested potential implications to higher education institutions in Thailand for developing spiritual leadership, such as organizing the six curriculums into students.
THE IMPACT OF COMPANY CHARACTERISTICS TO INCREASE COMPANY VALUE WITH CORPORATE RISK MANAGEMENT AS MEDIATION IN COMPANIES LISTED ON THE IDX IN 2016-2020
Authors: Sarsiti Sarsiti , Juni Trisnowati  , Erni Widiastuti
Published: January 2024

The research objectives are based on the research of Bohnert, A., et al., 2023 and Nguyen, Lan, et al. 2021, namely to examine the impact of size and leverage on firm value with enterprise risk management (ERM) as mediation. The sample technique used is purposive sampling, and the data used is secondary data from annual financial report data listed on the Indonesia Stock Exchange from 2016-2020, totaling 15 property and real estate industry sectors. Path analysis and the Sobel test are used in the data analysis technique. The findings indicated that: (1) firm size has a negative and insignificant impact on ERM; (2) leverage has a positive and insignificant impact on ERM; (3) firm value is positively but insignificantly impacted by company size and leverage; and (4) ERM has a negative and insignificant impact on firm value. (5) The impact of firm size and leverage on firm value is not mediated by ERM
Unravelling Emotional Tones: A Hybrid Optimized Model for Sentiment Analysis in Tamil Regional Languages
Authors: M Sangeetha , K Nimala
Published: January 2024

Review comments from digital platform such as Facebook, Twitter and YouTube used for identification of emotional tones from text. Nowadays, reviews are posted in different languages such as English, French, Chinese, and Indian regional languages such as Tamil, Telegu, and Hindi. Identification of emotional tones from text written in Indian regional language is challenging. During the translation of the regional language to the English language for sentiment analysis, lexical and pragmatic ambiguity are the major problem. The above problem arises due to dialects in language such as regional, standard, and social dialects. In this paper, dialect-based ambiguity problems solve through proposed Hybrid optimized deep learning transformer Models like M-BERT, M-Roberta, and M-XLM-Roberta for Tamil language dialects recognise and classified. The proposed algorithms provide better sentimental analysis after Hybrid optimization due to adaptation mechanisms, dynamic changes in the parameters and strategies in fine-tuning the search. The proposed Hybrid optimized algorithms perform better than existing algorithms such as SVM, Naïve Bayes, and LSTM with an accuracy of 95%.
Variety awareness, nutrition knowledge and adoption of nutritionally enhanced crop varieties: Evidence from Kenya
Authors:   Department of Agricultural Economics, University of Nairobi, Nairobi, Kenya, Nguthi Muthini Davis , Makau Nzuma Jonathan ,   Department of Agricultural Economics, University of Nairobi, Nairobi, Kenya, Adhiambo Nyikal Rose ,   Department of Agricultural Economics, Lilongwe University of Agriculture and Natural Resources, Lilongwe, Malawi.
Published: January 2024

This paper evaluates the impact of variety awareness and nutrition knowledge on the adoption of biofortified crop varieties using a sample of 661 households from Kisii and Nyamira counties in Kenya. The study employs the average treatment effect (ATE) framework to control for information on the KK15 bean variety and knowledge of its nutritional attributes among small-scale farmers. The results show that farmers who had knowledge of the nutritional attributes of KK15 beans were more likely to adopt relative to those who were only aware of the variety. A nutrition attribute knowledge gap of 8% was estimated, which represents the potential adoption loss due to a lack of knowledge of the nutritional benefits. Adoption of biofortified crops can therefore be improved by disseminating information on the varieties and their nutritional attributes. This can be achieved by entrenching nutrition information in extension packages disseminated to farmers.
The effect of climate change and agricultural diversification on the total value of agricultural output of farm households in Sub-Saharan Africa
Authors:   Faculty of Economics, Thammasat University, Bangkok, Thailand and World Bank, Washington DC, USA, Jithitikulchai Theepakorn
Published: January 2024

This study investigates the effect of temperature and precipitation on the economic value of agricultural output from farm households in six Sub-Saharan African countries: Ethiopia, Malawi, Niger, Nigeria, Tanzania and Uganda. Using a repeated cross-sectional dataset covering the period from 2008 to 2016, the study explores how the adverse effects of climate change vary among different levels of agricultural diversification. The findings reveal that a one-degree increase in temperature has a negative effect on the value of agricultural output. Nevertheless, households engaged in diversified production activities exhibit better adaptation to higher temperatures, leading to attenuated effects of climate change. Therefore, this study highlights the critical importance of diversification as a strategy to enhance the resilience of farm households in Sub-Saharan Africa.
Climate-induced crop failure and crop abandonment: What do we know and not know?
Authors:   Texas Tech University, Lubbock, Texas, Chekenya Nixon
Published: January 2024

Our understanding of climate-induced crop failure and crop abandonment is limited at present. This study surveyed theoretical and empirical literature on climate-induced crop failure and crop abandonment. We reviewed widely used models of crop abandonment decisions and emerging evidence of determinants of crop failure and crop abandonment. While most of the studies reviewed focus on crop failure, a very limited body of work examines crop abandonment decisions, with climate variables emerging as the key determinant. The review also highlights both theoretical and empirical models popular in the literature. We link crop failure and crop abandonment to weather variables and the resultant agricultural productivity loss and possible risk management strategies, highlighting policy implications and areas for future research.
Exploring the Mindset of Wonosari Village Citizens in the Mantra of the Grebeg Memetri Tradition, Tutur District, Pasuruan District (Ethnosemiotic Study)
Authors: Mardiana Ninik , Andharu Devito , Fadillah M Reza Ishadi , Setyawan Dedi
Published: January 2024

In the Pasuruan Regency of East Java Province, specifically in the Tutur Subdistrict, there is a village called Wonosari that holds a unique traditional ceremony to honor God, seek His blessings, and request safety from disasters for the village. The villagers of Wonosari conduct this traditional ceremony, which involves oral literature in the form of mantras. The mantras used in this tradition serve as prayers and are recited during the ritual burial of a cow's head in the center of the market. The mantras are recited by the village elders or traditional shamans during the ceremony. During the execution, the mantras are chanted aloud and listened to by the villagers of Wonosari in a solemn atmosphere.The traditional ritual of burying a cow's head in the village of Wonosari is known as Grebeg Memetri. The term "Grebeg" originates from a royal tradition aimed at distributing agricultural produce as charity to the people. The existence of mantras in the Grebeg Memetri tradition reflects the mindset of the village residents. This mindset is closely related to matters of belief, mythology, and experience. The villagers' mindset can be discerned from the oral traditions recited by the traditional shamans during the Grebeg Memetri ceremony. Investigating the mindset of the residents of Wonosari is intriguing, considering various aspects such as belief, mythology, and experience that accompany it.Given the issues described above, this research aims to examine the mindset of the residents of Wonosari through the oral tradition of Grebeg Memetri. To investigate the mindset of the villagers as manifested in the oral tradition of Grebeg Memetri, a literary approach called ethno-semiotics is required. Ethno-semiotics is an interdisciplinary field that combines ethnography and semiotics. The use of the ethno-semiotic approach is expected to represent the mindset of the residents of Wonosari based on the sign systems found in the oral tradition of Grebeg Memetri.
Il ruolo dell’editing nell’elaborazione dell’antigrafo
Authors: Baldassari Gabriele
Published: January 2024

A partire da alcune esperienze sul campo, il presente contributo mette in luce le difficoltà di ricostruire il passaggio dall’originale all’antigrafo di testi che hanno subito un processo editoriale moderno, entro il quale sono spesso coinvolte varie figure, talvolta numerose e parecchio diverse l’una dall’altra. In un tale contesto, infatti, è necessario considerare anche gli scambi tra l’autore, il redattore e le altre persone coinvolte, molti dei quali tuttavia, non sono documentabili. Dunque, anche per opere recentissime, come è normale in filologia, ciò a cui si può giungere è quasi sempre, se non sempre, solo un’approssimazione o un’ipotesi. 
The role of editing in creating the antigraph
Taking its cue from some relevant experiences within the field, this contribution highlights the difficulties in reconstructing the transition from the original to the antigraph of texts that have undergone a modern editorial process. This usually involves various figures, sometimes quite different from each other. In such a context, it is necessary to consider the exchanges between the author, the editor, and individuals, many of which, however, are not always documented. Therefore, even for works that have been very recently published, as is usual in philology, what can be achieved is almost always, if not always, only an approximation or a hypothesis.
Upaya Gereja Mewujudkan Dialog Antar Umat Beragama dalam Konteks Kemajemukan Agama
Authors: Prakosa Pribadyo
Published: January 2024

On the one hand, religious pluralism is something that can enrich the life of the Indonesian nation, but on the other hand it can become fertile ground for disputes, divisions, even bloodshed between one religion and another as well as acts of conflict and terrorism in the name of religion. Therefore, to avoid the outbreak of conflict between religious communities which could lead to violence, every religious follower needs to make efforts for dialogue between religious communities. The aim of the research is to describe and analyze the form and process of dialogue between religious communities carried out by the church, namely the Kalimantan Evangelical Church (GKE) Sion Basarang, Kapuas Regency, Central Kalimantan Province (hereinafter referred to as GKE Sion Basarang) which is one of the churches that lives in a pluralistic society both in terms of religion and ethnicity. The method used is qualitative with a descriptive-analytic research approach. The research results show that the form of dialogue between religious communities at GKE Sion Basarang is work dialogue and theological dialogue, meanwhile there are two stages in the dialogue process between religious communities, namely the first stage takes place spontaneously because church members live side by side in a pluralistic society and the The second is systematic because it is carried out through meetings between religious leaders, namely priests and other religious leaders.
Recognition of Sleep Disorders using IoT-Based Wearables and Neutrosophic Data Analytics
Authors:   College of Technological Innovation, Zayed University, Dubai, UAE, Taher Fatma
Published: January 2024

In the dynamic landscape of healthcare technology, the amalgamation of Internet of Things (IoT) systems and Neutrosophic Data Analytics has heralded a paradigm shift. This study delves deep into this transformative synergy by presenting an innovative IoT-based wearable system design for the recognition of sleep disorders. Our meticulously crafted multilayer cellular system seamlessly integrates IoT devices, data acquisition, cloud computing, and machine learning to unlock a wealth of insights into sleep patterns, their anomalies, and the presence of sleep disorders. Through fair and rigorous experimental comparisons, we unveil the prowess of Long Short-Term Memory (LSTM) within the machine learning realm, showcasing its superior performance over baseline models. The results affirm LSTM's ability to detect sleep disorders with remarkable accuracy, precision, and recall, revolutionizing sleep medicine and healthcare practices. This research, at the crossroads of innovation and healthcare, not only illuminates the path to advanced sleep disorder diagnosis but also heralds a new era of personalized healthcare interventions and remote monitoring solutions. As we navigate the realm of IoT and data-driven healthcare, our findings hold the promise of improving the quality of life for countless individuals, reaffirming the pivotal role of technology in safeguarding one of the most fundamental aspects of human well-being – a peaceful and restorative night's sleep.
The Heckscher-Ohlin Model in Modern International Trade
Authors: Lu Runlin
Published: January 2024

The Heckscher-Ohlin model, initially developed by Elie Heckscher and Bertil Ohlin, remains a cornerstone of international economics. This paper evaluates the model's relevance in the context of contemporary global trade dynamics, with a specific focus on how changes in relative factor abundance among countries continue to influence long-term trade patterns. By combining historical perspectives with modern insights, this study seeks to provide a comprehensive understanding of the model's applicability in today's interconnected world. While empirical research continues to validate its core principles, the study also acknowledges the complexities of real-world trade, including technological advancements, trade policies, and non-homogeneous factors of production. In conclusion, the Heckscher-Ohlin model remains an invaluable tool for understanding international trade, but its effective application requires an integrated approach that considers the multifaceted nature of today's global economy, guiding policymakers and businesses in navigating the evolving landscape of international trade.
Peran Guru dalam Mengatasi Kesulitan Membaca Permulaan Siswa Kelas 1
Authors: Hani Siti Umi , Rofi’ah Gina
Published: January 2024

Penelitian ini bertujuan untuk menganalisis kemampuan membaca permulaan siswa kelas I MI An-Nihrir beserta peran guru dalam mengatasi kesulitan membaca permulaan tersebut. Penelitian ini menggunakan kualitatif dengan metode deskriptif dan mengamati 5 siswa yang mengalami kesulitan membaca permulaan. Pengempulan data dengan menggunakan Teknik observasi, wawancara dan dolumntasi. Berdasarkan hasil penelitian kesulitan membaca permulaan pada siswa kelas 1 di MI An-Nihrir dengan kondisi yang berbeda-beda, diantaranya adalah siswa mengalami kesulitan membaca dengan kondisi pembalikan huruf, pengucapan kata yang salah, membaca dengan tersendat-sendat dan membaca dibantu oleh guru. Untuk mengatasi kesulitan membaca permulaan, guru berperan sebagai innovator, fasilitator, pengajar dan motivator.
Faktor Organisasi Regional di Timur Tengah Tidak Berhasil Mencegah Konflik
Authors: Rasendrianto Daffa Raihan
Published: January 2024

Faktor Organisasi Regional di Timur Tengah Tidak Berhasil Mencegah Konflik
Penelitian ini dilakukan untuk membahas mengenai kegagalan organisasi regional di Kawasan Timur Tengah dalam mengatasi konflik. Organisasi regional mempunyai peran yang krusial dalam mengatasi konflik yang terjadi terutama pada anggotanya. Meskipun idealnya mereka berusaha mensejahterakan anggotanya, namun pada kenyataannya mereka belum berhasil untuk mengatasi konflik. Situasi ini terjadi pada organisasi regional di Kawasan Timur Tengah. Untuk mengetahui faktor yang menyebabkan kegagalan organisasi regional di Kawasan Timur Tengah, penelitian ini menggunakan metode penelitian kualitatif dan menggunakan pendekatan studi kasus. Studi kasus akan dilakukan pada konflik yang terjadi di Libya, yaitu Perang Sipil Libya dan Liga Arab sebagai organisasi regional yang berperan untuk mengatasi konflik tersebut. Terdapat dua faktor yang menyebabkan organisasi di Kawasan Timur Tengah tidak dapat mengatasi konflik. Pertama, terdapat kepentingan politik anggota organisasi sehingga mendahulukan hal tersebut sebagai prioritas mereka. Kedua, adanya ketimpangan kekuatan antara sesama anggota organisasi yang menyebabkan pemanfaatan kekuatan bagi mereka yang memilikinya. Dengan faktor-faktor yang telah disebutkan, diharapkan bahwa setiap anggota organisasi dapat mengesampingkan kepentingan politik mereka untuk membantu sesama anggota sesuai dengan tujuan utama dibentuknya organisasi. Petinggi organisasi pun dapat menjalankan sanksi bagi anggota yang tidak mengikuti peraturan.
Meningkatkan Kemampuan Skill Membaca dan Berfikir Kritis Menghadapi Ancaman AI di Era Digital yang Semakin Modern
Authors: Saiddaeni Saiddaeni , Zulfandika Achfan Aziz , Fitriana Andalusia Ajeng , Nugroho Fariz Nurman Adi , Huda Itsnindar Nur
Published: January 2024

Bagi sebagian orang, Kecerdasan Buatan dianggap sebagai ancaman terhadap keberadaan manusia dan peluang kerja. Namun, saya memandang fenomena ini secara berbeda. Bagi sebagian orang, AI akan menempati banyak peluang kerja. Namun, bagi saya, manusia telah dan masih menjadi bagian dari masa depan. Manusia memiliki mekanisme berpikir yang sangat berbeda dibandingkan AI. Jika manusia ingin berada di peta, manusia harus mengembangkan keterampilan yang tidak dapat dicapai oleh AI seperti intuisi dan empati. Berpikir kritis dan belajar adalah kunci untuk mencapai tujuan tersebut. Dalam tulisan ini, saya akan membuktikan pendirian saya berdasarkan metode penelitian yang disebut Systematic Literature Review (SLR). Masih banyak ruang kompetisi bagi manusia ketika berhadapan dengan AI. Yang terpenting adalah manusia harus melihat dan memahami bahwa manusia memiliki kelebihan dibandingkan dengan AI. Kelebihan manusia ketimbang AI ini harus diwujudkan dengan belajar dan membaca kritis. Caranya adalah dengan manusia belajar tanpa harus terbebani mencapai kompetensi tertentu, merefleksikan apa yang manusia pelajari, memandang ilmu dengan empati dan visioner serta kemudian mempersonalisasi ilmu yang telah manusia pelajari agar menjadi bagian dari diri manusia untuk kemudian dapat menggunakan ilmu tersebut untuk kepentingan yang lebih baik di masa depan.
Mechanism of long-term high-dose prednisolone administration producing myocardial fibrosis in beagle dogs
Authors: Tanaka Sachiyo , Suzuki Shuji , Soeta Satoshi , Kaneda Takeharu , Hara Yasushi
Published: January 2024

Background:
We previously reported that myocardial fibrosis may be one of the causes of left ventricular hypertrophy and cardiac dysfunction in dogs with hyperglucocorticism (HGC). The detailed mechanism by which myocardial fibrosis of the left ventricle occurs in dogs with hyperglucocorticism (HGC) remains unclear.
Aim:
This study investigated the mechanism by which HGC causes fibrosis of the left ventricle.
Methods:
The impacts of HGC on the heart by comparing samples obtained from high-dose glucocorticoid-treated (P) and untreated (C) dogs. The P group included healthy Beagle dogs (n=6) treated with prednisolone (2 mg/kg, bid, po) for 84 days, and the C group included healthy Beagle dogs (n=6) euthanized for unrelated reasons. In three of the P group dogs, serum was collected before the start of administration (Day 0) and on Day 84 to measure angiotensin II concentrations and oxidative stress markers (8-hydroxy-2’-deoxyguanosine (8OHdG), NADPH oxidase, and superoxide levels). Samples of the left ventricular free wall (LVFW), right ventricular free wall (RVFW), interventricular septum (IVS), and aortic root were harvested from both groups (n = 6 for each group). Using these tissue samples, angiotensin II type 1 receptor (AT1R), 8OHdG, and transforming growth factor β1 (TGFβ1) immunohistochemical stains were performed.
Results:
The blood NADPH oxidase concentration was significantly higher (P=0.027) in the P group 84 days after initiation of the medication compared to that before prednisolone treatment. By contrast, there was no significant difference in serum angiotensin II (P=0.450), 8OHdG (P=0.068), and superoxide (P=0.057) concentrations. The positive staining rates of AT1R, 8OHdG, and TGFβ1 in the heart (LVFW, RVFW, IVS, and aortic root) were significantly higher in the P group than those in the C group.
Conclusion:
Angiotensin II and oxidative stress in HGC may cause left ventricular fibrosis in dogs.
Analysis for the diagnostic accuracy of PCR detection of Macrorhabdus in companion birds
Authors: Kanno Shoko , Matsumoto Yusuke
Published: January 2024

Background:
Macrorhabdus ornithogaster, a yeast-like fungus, has the potential to infect various bird species, including companion birds. Although birds infected with M. ornithogaster may often remain asymptomatic, the infection can develop into chronic wasting gastritis and even progress to gastric cancer, highlighting the importance of early detection of M. ornithogaster infection. Despite direct fecal examination being a commonly used diagnostic method, the polymerase chain reaction (PCR) is anticipated to offer a higher detection rate. However, the actual diagnostic accuracy of the PCR for M. ornithogaster remains unknown.
Case Description:
Ninety fecal samples collected from companion birds that visited or were admitted to a hospital, regardless of their stage of Macrorhabdus diagnosis or treatment, were subjected to PCR testing. An accuracy analysis was then performed, considering symptomatology, direct fecal testing, and sequencing. The PCR test had a sensitivity of 83.33 %, specificity of 95.00 %, false negative rate of 16.67%, false positive rate of 5.00%, positive predictive value of 89.29%, negative predictive value of 91.94%, prevalence of 33.33 %, positive likelihood ratio of 16.67, negative likelihood ratio of 0.18, and diagnostic odds ratio of 95.00.
Conclusion:
The findings suggest that the PCR for Macrorhabdus possesses high diagnostic accuracy, with the ability to accurately identify uninfected individuals as negative. While the direct fecal examination is appropriate for routine primary screening, in cases where M. ornithogaster is not detected by fecal testing, the PCR may provide a more accurate and definitive diagnosis due to its high specificity.
Metabolomic and proteomic changes in Standardbred horses in training
Authors: Johansson Lisa
Published: January 2024

Metabolomic and proteomic changes in blood plasma were analysed in 16 young Standardbred horses from the age of 1.5 to 3.5 years. All horses had the same training programme from September as 1.5-year-olds until March as 2-year-olds, when highintensity training was introduced and the horses were divided into two training groups, High and Low. Both groups followed the same training programme, but the Low group performed 30% shorter high-intensity training distances than the High group. The same speed was aimed for with both groups. In blood samples collected from age 1.5 to 3.5 years, insulin-like growth factor 1 (IGF-1) was analysed with an ELISA kit, metabolomic profile was analysed using targeted absolute quantitative mass spectrometry and proteomic profile was analysed using untargeted mass spectrometry. There was no significant difference in IGF-1 between the training groups, but the expected ongoing IGF-1 decline was interrupted at a time which coincided with the onset of high-intensity training. Metabolomic differences between the training groups were only observed at 2 years of age, but concentrations of several metabolites changed significantly over time compared with at 1.5 years of age. Metabolites that differed significantly between the training groups and over time are associated with aerobic energy production and amino acid metabolism, and potentially also pH-buffering and vascular responses. The proteomics data did not reveal any significant differences between the training groups but the concentrations of 17 proteins related to energy metabolism, bone formation and circulatory functions changed significantly over time. In summary, both the metabolomic and proteomic profile in young horses in training changed over time, while the metabolic profile was also affected by training programme.
Growth and Storage Study of Streptococcus agalactiae as a Potential Target in Whole-Cell Based ‘Systematic Evolution of Ligands by Exponential Enrichment (SELEX)’ Procedure
Authors: Tan Pei Qin , Gan ZiXuen , Wasoh Helmi , Yasid Nur Adeela , Shukor Mohd Yunus , Halim Murni , Yusof Mohd Termizi , Hashim Amalia Mohd , Abdullah Jaafar , Manaf Yanty Noorzianna
Published: January 2024

Streptococcus agalactiae is a pathobiont that causes severe invasive infections, especially in fishponds or freshwater aquatic organisms. Streptococcus outbreak in cultured fishponds causes a negative impact on the production of fishes, especially tilapias. Therefore, it is essential to develop a reliable method for on-site monitoring of S. agalactiae in fishponds. This study aims to investigate a local S. agalactiae strain TP540K as a potential target for DNA aptamer in a whole-cell based ‘systematic evolution of ligands by exponential enrichment (SELEX)’ procedure. Before this procedure, the bacterial growth profile of S. agalactiae strain TP540K was studied. Besides, the viability of S. agalactiae strain TP540K was compared between different storage solutions (glycerol, phosphate buffer saline, distilled water) and temperatures (-20, 4 and 27 °C). In this study, S. agalactiae strain TP540K entered the log phase at 1.5 h of incubation time, thus the cells were collected at 2 h of incubation time with an OD600 value of 0.436 to proceed to SELEX process. Moreover, glycerol stock (20%, -20 °C) was the best storage condition for preservation of S. agalactiae strain TP540K until Day 84 with a cell viability of 2.48 x 107 CFU/mL. With the findings obtained, S. agalactiae strain TP540K could be utilised as a target for future study in DNA aptamer development through whole-cell based SELEX procedure, which could be useful for future investigations to overcome Streptococcus outbreak in the Malaysian aquaculture industry.
Perception of UHT Ready-to-Drink Coconut Water in Bangkok via Online Media
Authors:   Department of Communication Innovation and Agricultural Development, Faculty of Agricultural Technology,  King Mongkut’s Institute of Technology Ladkrabang, Bangkok, 10520, Mokanan Songtham , Eamkijkarn Sabaijai Phatchara ,   Department of Communication Innovation and Agricultural Development, Faculty of Agricultural Technology,  King Mongkut’s Institute of Technology Ladkrabang, Bangkok, 10520
Published: January 2024

The objective of this research was to study the awareness of UHT coconut water in Bangkok via an online channel. Survey responses were collected from 404 participants (age range of 18 to 40 years old) who were exposed to online media and consumed UHT ready-to-drink coconut water. The data collected were then analyzed by descriptive statistical analysis for frequency, relative frequency, and standard deviation. The results showed that the group that has the highest awareness of online media is female (62.10%) at the age between 24 to 29 years old (48.00%), having bachelor's degrees (76.00%), and being employed in private companies (49.80%) with a salary range of 20,001-30,000 baht per month (30.90%). For the overall perception of UHT ready-to-drink coconut water, there is a high awareness from online media exposure of (x̄ = 3.84) and factors rank from high to low, i.e. Convenience (x̄ = 4.01), Communication (x̄ = 3.92), and worthiness (x̄ = 3.75), and consumers (Cost of Consumer) (x̄ = 3.69). respectively. It can be concluded that consumers order UHT ready-to-drink coconut water online due to its convenience.
Unraveling the Symphony: How the COVID-19 Pandemic Orchestrated Changes in Working Capital Management within the Steel Industry
Authors:   Faculty of Commerce Banaras Hindu University, Varanasi, Singh Disha , Singh Shivani ,   Faculty of Commerce Banaras Hindu University, Varanasi
Published: January 2024

The world health organisation (WHO) has discovered a novel coronavirus known as COVID- 19, which has shattered human civilization and the global economy. The study is based on the impact of covid on working capital Management in selected public sector steel industry in India. The period of study taken for prior covid is 2016-2019 and 2019-2022. The study describes a favorable correlation, both before and after the advent of the COVID-19 pandemic (r = 0.649, p < 0.001). There is no significant difference between (t=1.510, p < 0.001). On average, the points prior to COVID exceeded those after COVID by 21844.69 points. (95% CI-8083.24, 51772.63]). Keywords: Working Capital Management, Covid 19, Steel Industry, Paired Sample t test.
Pemanfaatan Model Modifikasi Blended Learning dalam Pembelajaran Bahasa Bali pada Masa Pandemi Covid-19
Authors: Miarta Putra I Nyoman
Published: January 2024

This study aims to share the best learning experiences during the Covid-19 pandemic. Finding a suitable learning model in the midst of this epidemic, the authors innovate because of government policies that cover the implementation of distance learning. Modifying the learning paradigm of Blended Learning is one of them. Blended learning is a type of learning that combines online and face-to-face instruction. Because the face-to-face learning method cannot be implemented directly, changes must be made. Changes are made on both sides, both online and in person. From packaging subject information to offering discussion space for students to explain elements that are not yet understood, the online side is being modified. The study of small test results was used as a starting point for designing virtual "face to face" learning techniques. Meanwhile, learning takes place informally through Zoom Meeting media at the face-to-face stage. For students who are unable to participate in live learning via Zoom due to network problems or internet limitations, the teacher sends learning videos with small file capacities. Videos are stored in LMS Schoology and can be accessed and downloaded at any time. Modified Blended Learning can be used as a learning technique during the Covid-19 pandemic, according to the findings. In addition, it is known that the education unit requires teachers and students to be trained in the use of digital technology gadgets. School systems thinking must also evolve to recognize that learning can take place outside the classroom and can be accessed from anywhere. The government will be forced to boost free wifi facilities as a result of the implementation of this Blended Learning change. Because we live in the digital era, the internet network plays an important role in helping the teaching and learning process.
Pola Komunikasi Interpersonal Antar Pustakawan Dan Pemustaka Dalam Meningkatkan Kualitas Pelayanan Pada Perpustakaan Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar
Authors: Eka Kurniawan Wayan Ngurah
Published: January 2024

The library is a work unit in the form of a place for collecting, storing and maintaining library material collections that are managed and systematically arranged in a certain way, to be used sustainably by users as a source of information. Good library management can support education and the learning process in higher education, with good communication patterns it will have an impact on the quality of service at the library. Universitas Hindu Negeri I Gusti Bagus Sugriwa is a university that has just changed its status to a university in 2020. Based on this formulation, the theories used to dissect the formulation of the problem are: (1) Communication Planning Theory, (2) Discourse Theory, and (3) Social Action Theory. This research took place in the library of Universitas Hindu Negeri I Gusti Bagus Sugriwa. The type of research used is qualitative, with the determination of informants using purposive sampling method. Collecting data using observation methods, interviews with guidelines assisted by voice recorder research tools and cellphones, literature and documentation. Data analysis carried out in this study used data reduction, data presentation, and data verification. The findings of this study, namely in its implementation, the existence of librarians in establishing communication with users using verbal and non-verbal communication patterns in providing information to users so that users make it easier to find library materials in the library of Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar, will have an impact on the quality of existing resources, Libraries in service to users use an open management system in serving users where users look for library materials on library shelves according to the field they are involved in.
Kajian Ekologi Lingkungan Dalam Upacara Ngelukat Gumi
Authors: Sastrawan Gede Arma
Published: January 2024

Ekologi dalam upacara Ngelukat Gumi memiliki arti penting dalam konteks permbersihan atau penyucian alam semesta yang melibatkan aspek Bhuana Agung(alam makrokosmos) dan Bhuana Alit(alam mikrokosmos),Ngelukat Gumi merupakan sebuah upacara dalam catur Desa Adat Dalem Tamblingan yang dijadikan tujuan menjaga keharmonisan dan keseimbangan alam semesta.Dalam upacara Ngelukat Gumi,masyarakat Catur Desa melibatkan aspek ekologi dengan cara membersihkan dan menyucikan alam semesta,pembersihan alam semesta ini mencakup dua dimensi penting yaitu Bhuana Agung Dan Bhuana Alit.Bhuana Agung mencerminkan alam semesta secara keseluruhan atau dalam konteks luas,termasuk kedalam elemen air,tanah,udara,dan api.Bhuana Alit mencapuk aspek Mikrokosmos seperti tumbuhan,binatang,dan manusia.Selain aspek fisik,Ngelukat Gumi juga memiliki dimensi spiritual yang tinggi berkaitan dengan Ekologi,umat Hindu percaya bahwa alam semesta adalah tempat tinggal bagi roh-roh leluhur dan para dewa, menjaga kesucian alam semesta berarti menjaga hubungan spiritual dengan mereka.Dalam Upacara Ngelukat Gumi umat hindu berharap untuk mendapatkan berkah dan keharmonisan dengan alam semesta .Upacara Ngelukat Gumi menunjukkan kesadaran akan pentingnya Ekologi dan keberlanjutan alam semesta ,ini mencerminkan pemahaman bahwa kehidupan manusia tidak dapat dipisahkan dari lingkungan hidupnya ,dengan menjaga Ekologi,umat Hindu berharap untuk menciptakan keharmonisan antara manusia dan alam serta mewujudkan kehidupan yang lebih berkelanjutan bagi generasi saat ini dan dimasa depan
Eksistensi Perempuan Bali Dalam Budaya Patriarki
Authors: Alit Septiari Desak Made , Widya Dhammayanti I Gusti Ayu
Published: January 2024

Women and their existence are two things that are very closely related. If you look at history, Indonesia has many female figures who contributed to the country's progress, which proves that women are also capable of making changes that are just as significant as men. The struggle for gender equality began with introducing formal education to Indonesian women, as was done by Raden Ayu Adipati Kartini Djojoadhiningrat (Raden Ajeng Kartini). Not only that, Bali also has female figures such as Raden Ajeng Kartini named I Gusti Ayu Rapeg, she and her friends are persistent in visiting people's houses one by one to introduce education for women. The struggle for gender equality fought by female leaders in fact must continue to this day. Many people still underestimate women, especially in areas that adhere to a patriarchal system. This phenomenon is something that must be addressed so that in the future women will have more space to express, create, and feel safe in public spaces.
Limfadenopati Tuberkulosis dengan Drugs-induced Hepatitis (DIH) di Sikka, Nusa Tenggara Timur, Indonesia
Authors: Rahmad David Denada , Purnama Asep
Published: January 2024

Latar belakang: Limfadenopati TB merupakan TB ekstraparu terbanyak dengan persentase 35% total kasus di dunia. Drugs-induced hepatitis (DIH) adalah salah satu risiko efek samping obat anti-tuberkulosis (OAT). Kasus: Pria berusia 18 tahun dengan beberapa benjolan di leher sebelah kanan yang dirasa nyeri sejak 2 minggu. Pemeriksaan fisik mendapatkan beberapa benjolan submandibular dan supraklavikula kanan. Biopsi benjolan mendapatkan hasil limfadenitis granulomatous supuratif. Pasien didiagnosis limfadenopati TB dan diberi OAT Kategori 1. Lima hari kemudian, pasien mual muntah dan terjadi peningkatan AST/ALT. OAT dihentikan sementara hingga klinis dan laboratorium kembali normal. OAT selanjutnya diberikan secara individual. Simpulan: Pasien TB dan DIH memerlukan terapi individual berdasarkan toleransi terhadap obat. Perlu pemantauan klinis dan laboratorium saat pengobatan agar efek samping dapat dicegah dan pengobatan bisa berhasil.
Komplikasi Okular pada Demam Dengue
Authors: Putra Iqra Haikal Hamas , Priyantono Rabiul , Purnama Mia
Published: January 2024

Ocular complications rarely occur in dengue fever, but were reported increasing. Several studies showed that cross-reactive antibody is responsible for ocular involvement in dengue. Blurred vision, followed by posterior segment involvement was seen in most cases. A simple examination in primary medical care such as the Amsler grid may detect scotoma and metamorphopsia. Early recognition of ocular involvement in dengue cases may prevent morbidity.
Efektivitas Citicoline dalam Terapi Demensia
Authors: Ar Rochmah Mawaddah , Indrihapsari Erupsiana Fitri , Nugroho Dhite Bayu
Published: January 2024

Background: In the development of pharmacological therapy for dementia, especially Alzheimer's disease, several types of therapy are widely used: acethylcholine esterase inhibitors/AChEI, N-methyl-D-aspartate (NMDA) receptors inhibitors, and cholinergic precursor. Aim: To review the evidence on the effectiveness of citicoline supplementation to the standard therapy of dementia to prevent the progression or improve the manifestations of dementia. Methods: A literature search was performed in three following databases: Pubmed, EBSCOhost, Scopus, and Cochrane within the last ten years. Results: Of the 239 articles, five studies were eligible for critical appraisal. Four studies showed a significant mean MMSE score increase in the citicoline + standard therapy group (intervention) compared to the standard therapy group (control) during the follow up period between 3 – 12 months. One study showed a significant mean MMSE score increase of in the intervention group compared to the control group. Conclusion: Oral citicoline supplementation of 1,000 mg/day to the standard therapy showed a positive effect on cognitive function in dementia patients. Critical appraisal of validity and application of the included studies should be considered upon daily clinical application.
Auditoria informática a centros de estudios. Caso U.E. “Nuestra Señora de Fátima”
Authors: Zhuño Sahiry , Heredia Santiago , Paltan David
Published: January 2024

La Auditoría Informática se ocupa de comprobar el adecuado desempeño de los equipos 13 computacionales y software institucional, así como examinar la legalidad o ilegalidad de los programas 14 que tiene la institución para de esta forma prevenir inconvenientes en el campo legal o sugerir la compra 15 de licencias, caso contrario se debe proceder a la desinstalación de estos, del mismo modo detectar 16 programas que no se necesitan para llevar a cabo el trabajo conforme el cargo que se tenga. Estos y otros 17 aspectos como el entorno, seguridad, redes de telecomunicaciones y personal se tomaron en cuenta para 18 el desarrollo del proyecto el cual proporcionará conclusiones y recomendaciones finales en base a los 19 hallazgos que se susciten. La Unidad Educativa “Nuestra Señora de Fátima” en la ciudad de Riobamba 20 carece de un manual de Auditoría Informática, en el cual se detalle información del estado del centro de 21 cómputo que a diario es utilizado por estudiantes y docentes para llevar a cabo las actividades de 22 enseñanza y aprendizaje. Gracias al presente plan investigativo se logrará tener un mejor control en el 23 campo informático de las distintas zonas.
Comparativa De Herramientas Tics Aplicadas En El Proceso De Auditoria Informática
Authors: Salcán Cristian
Published: January 2024

El artículo científico aborda la comparativa de dos herramientas de tecnología de la información (TI), Netwrix Auditor y ACL Analytics, en el contexto de la auditoría informática. Se examinan sus características, funcionalidades y alcances, destacando su importancia en la evaluación de la integridad de los datos y el cumplimiento normativo. El objetivo del artículo es realizar una comparativa entre las herramientas de tecnología de la información en el proceso de auditoría informática, También se discute la eficiencia, facilidad de uso, adaptabilidad y soporte técnico de ambas herramientas, así como su costo. Se concluye que la elección entre ellas depende de las necesidades específicas de cada organización, y que su utilización junto con la auditoría continua fortalece los procesos de auditoría informática y ayuda a identificar riesgos en un entorno digitalizado.