bluuebunny/crossref_metadata_2025 huggingface dataset:
The Study of an Adaptive Bread Maker Using Machine Learning
Authors: Lee Jooho , Kim Youngjin , Kim Sangoh
Published: November 2023

Bread is one of the most consumed foods in the world, and modern food processing technologies using artificial intelligence are crucial in providing quality control and optimization of food products. An integrated solution of sensor data and machine learning technology was determined to be appropriate for identifying real-time changing environmental variables and various influences in the baking process. In this study, the Baking Process Prediction Model (BPPM) created by data-based machine learning showed excellent performance in monitoring and analyzing real-time sensor and vision data in the baking process to predict the baking stages by itself. It also has the advantage of improving the quality of bread. The volumes of bread made using BPPM were 127.54 ± 2.54, 413.49 ± 2.59, 679.96 ± 1.90, 875.79 ± 2.46, and 1260.70 ± 3.13, respectively, which were relatively larger than those made with fixed baking time (p < 0.05). The developed system is evaluated to have great potential to improve precision and efficiency in the food production and processing industry. This study is expected to lay the foundation for the future development of artificial intelligence and the food industry.
Red Meat Consumption and Cancer Risk: A Systematic Analysis of Global Data
Authors: Ma Hongyue , Qi Xiangming
Published: November 2023

The association between red meat consumption and cancer risk remains a controversy. In this study, we systematically collected and analyzed global data (from Our World in Data and Global Cancer Observatory) to investigate this association for the first time. Our results confirmed significant positive associations between red meat consumption (RMC) and overall cancer incidence (0.798, p < 0.001), or colorectal cancer incidence (0.625, p < 0.001). Several previously unreported cancer types linked to RMC were also unveiled. Gross domestic product (GDP) per capita were found to have an impact on this association. However, even after controlling it, RMC remained significantly associated with cancer incidence (0.463, p < 0.001; 0.592, p < 0.001). Meanwhile, after controlling GDP per capita, the correlation coefficients between white meat consumption and overall cancer incidence were found to be much lower and insignificant, at 0.089 (p = 0.288) for poultry consumption and at −0.055 (p = 0.514) for seafood and fish consumption. Notably, an interesting comparison was performed between changes of colorectal cancer incidence and RMC in many countries and regions. A lag of 15–20 years was found, implying causality between RMC and cancer risk. Our findings will contribute to the development of more rational meat consumption concept.
Polymeric Hydrogels for Intervertebral Disc Replacement/Integration: Playing with the Chemical Composition for Tuning Shear Behavior and Hydrophilicity
Authors: Maniglio Devid , Bissoli Elia , Callone Emanuela , Dirè Sandra , Motta Antonella
Published: November 2023

Damages to the intervertebral disc (IVD) due to improper loading or degeneration result in back pain, which is a common disease affecting an increasing number of patients. Different strategies for IVD remediation have been developed, from surgical treatment to disc replacement, by using both metallic and non-metallic materials. Hydrogels are very attractive materials due to their ability to simulate the properties of many soft tissues; moreover, their chemical composition can be varied in order to assure performances similar to the natural disc. In particular, for the replacement of the IVD outer ring, namely, the anulus fibrosus, the shear properties are of paramount importance. In this work, we produced hydrogels through the photo-induced crosslinking of different mixtures composed of two hydrophilic monofunctional and difunctional polymers, namely, poly(ethyleneglycol) methyl ether methacrylate (PEGMEMA) and poly(ethyleneglycol) dimethacrylate (PEGDMA), together with a hydrophobic molecule, i.e., tert-butyl acrylate (tBA). By changing the ratio among the precursors, we demonstrated the tunability of both the shear properties and hydrophilicity. The structural properties of hydrogels were studied by solid-state nuclear magnetic resonance (NMR). These experiments provided insights on both the structure and molecular dynamics of polymeric networks and, together with information obtained by differential scanning calorimetry (DSC), allowed for correlating the physical properties of the hydrogels with their chemical composition.
Unveiling the Genetic Basis Underlying Rice Anther Culturability via Segregation Distortion Analysis in Doubled Haploid Population
Authors: Sun Bin , Ding Xiaorui , Ye Junhua , Dai Yuting , Cheng Can , Zhou Jihua , Niu Fuan , Tu Rongjian , Hu Qiyan , Xie Kaizhen , Qiu Yue , Li Hongyu , Feng Zhizun , Shao Chenbing , Cao Liming , Zhang Anpeng , Chu Huangwei
Published: November 2023

Anther culture (AC) is a valuable technique in rice breeding. However, the genetic mechanisms underlying anther culturability remain elusive, which has hindered its widespread adoption in rice breeding programs. During AC, microspores carrying favorable alleles for AC are selectively regenerated, leading to segregation distortion (SD) of chromosomal regions linked to these alleles in the doubled haploid (DH) population. Using the AC method, a DH population was generated from the japonica hybrid rice Shenyou 26. A genetic map consisting of 470 SNPs was constructed using this DH population, and SD analysis was performed at both the single- and two-locus levels to dissect the genetic basis underlying anther culturability. Five segregation distortion loci (SDLs) potentially linked to anther culturability were identified. Among these, SDL5 exhibited an overrepresentation of alleles from the female parent, while SDL1.1, SDL1.2, SDL2, and SDL7 displayed an overrepresentation of alleles from the male parent. Furthermore, six pairs of epistatic interactions (EPIs) that influenced two-locus SDs in the DH population were discovered. A cluster of genetic loci, associated with EPI-1, EPI-3, EPI-4, and EPI-5, overlapped with SDL1.1, indicating that the SDL1.1 locus may play a role in regulating anther culturability via both additive and epistatic mechanisms. These findings provide valuable insights into the genetic control of anther culturability in rice and lay the foundation for future research focused on identifying the causal genes associated with anther culturability.
The Whole-Exome Sequencing of a Cohort of 19 Families with Adolescent Idiopathic Scoliosis (AIS): Candidate Pathways
Authors: Marie-Hardy Laura , Courtin Thomas , Pascal-Moussellard Hugues , Zakine Serge , Brice Alexis
Published: November 2023

A significant genetic involvement has been known for decades to exist in adolescent idiopathic scoliosis (AIS), a spine deformity affecting 1–3% of the world population. However, though biomechanical and endocrinological theories have emerged, no clear pathophysiological explanation has been found. Data from the whole-exome sequencing performed on 113 individuals in 19 multi-generational families with AIS have been filtered and analyzed via interaction pathways and functional category analysis (Varaft, Bingo and Panther). The subsequent list of 2566 variants has been compared to the variants already described in the literature, with an 18% match rate. The familial analysis in two families reveals mutations in the BICD2 gene, supporting the involvement of the muscular system in AIS etiology. The cellular component analysis revealed significant enrichment in myosin-related and neuronal activity-related categories. All together, these results reinforce the suspected role of the neuronal and muscular systems, highlighting the calmodulin pathway and suggesting a role of DNA-binding activities in AIS physiopathology.
Comparative Transcriptomic Analysis of Largemouth Bass (Micropterus salmoides) Livers Reveals Response Mechanisms to High Temperatures
Authors: Zhou Fan , Qi Ming , Li Jiapeng , Huang Yuanfei , Chen Xiaoming , Liu Wei , Yao Gaohua , Meng Qinghui , Zheng Tianlun , Wang Zhanqi , Ding Xueyan
Published: November 2023

High temperatures are considered one of the most significant limitations to subtropical fishery production. Largemouth bass (Micropterus salmoides) is an economically important freshwater species grown in subtropical areas, which are extremely sensitive to heat stress (HS). However, comprehensive transcriptomic data for the livers of largemouth bass in response to HS are still lacking. In this study, a comparative transcriptomic analysis was performed to investigate the gene expression profiles of the livers of largemouth bass under HS treatment. As a result, 6114 significantly differentially expressed genes (DEGs), which included 2645 up-regulated and 3469 down-regulated genes, were identified in response to HS. Bioinformatics analyses demonstrated that the ‘ECM-receptor interaction’ pathway was one of the most dramatically changed pathways in response to HS, and eight DEGs assigned to this pathway were taken as hub genes. Furthermore, the expression of these eight hub genes was determined by quantitative reverse transcription PCR, and all of them showed a significant change at the transcriptional level, suggesting a crucial role of the ‘ECM-receptor interaction’ pathway in the response of largemouth bass to HS. These findings may improve our understanding of the molecular mechanisms underlying the response of largemouth bass to HS.
Outcome of Involuntary Mental Health Assessment in a Psychiatric Department in Greece
Authors: Papadopoulou Vasiliki , Arvaniti Aikaterini , Kalamara Eleni , Georgaca Eugenie , Stylianidis Stelios , Peppou Lily E. , Samakouri Maria
Published: November 2023

Despite their controversiality, involuntary admissions in psychiatric departments remain a central issue in mental health care. The present study aims to identify demographic and clinical factors possibly associated with emergency involuntary psychiatric assessment and its outcome in Greece. This study was carried out in the psychiatric department of the University General Hospital of Alexandroupolis (UGHA) from 1 March 2018 to 28 February 2019. The sample included 191 individuals who had been psychiatrically assessed without their consent following a prosecutorial order. The majority of the involuntary assessments resulted in hospitalization (71%), with 51% of them resulting in involuntary hospitalization. Almost all patients diagnosed with “F20–29 schizophrenia, schizotypal and delusional disorders” were subsequently admitted to the psychiatric department of the UGHA (77 of 81, 66 of them involuntarily). Higher admission rates were recorded among those who had been referred from the Prosecutor’s Office of regions that are located far from the psychiatric department of UGHA (Fisher’s exact test, p-value = 0.045). In multivariate logistic regression, prior contact with psychiatric services and having an “F20–29 schizophrenia, schizotypal and delusional disorders” diagnosis was statistically significant with admission to the hospital as an outcome variable. Our study suggests an increased risk of involuntary admission among patients with psychosis, patients who had visited a psychiatric service prior to their assessment as well as those living further away from the main psychiatric services of the hospital. Better organization of community psychiatric services in remote places from hospital central services may lead to fewer prosecutorial referrals and coercive measures.
Paul Delvaux: The Study of Nine Paintings by Non-Invasive Methods
Authors: Derzelle Edène , Strivay David , Defeyt Antoine , Klein Sarah-Jane , Vandepitte Francisca , Defeyt Catherine
Published: November 2023

Paul Delvaux (1897–1994) was a Belgian Surrealist painter known for his dreamlike and enigmatic compositions. His works often featured nude or semi-nude women and deserted urban landscapes, evoking a sense of mystery and intrigue. Delvaux’s meticulous attention to detail and masterful use of light and shadow added depth and realism to his surrealistic style, making him one of the leading figures of the Belgian Surrealist movement. Although writings about Paul Delvaux’s work are not lacking, the literature mainly deals with the stylistic and iconographic aspects of his work. Taking an interest in painting materials and the painter’s technique allows us to understand his personality and to apprehend his work in a different way. In order to collect such information, the early painted production of Delvaux was studied in situ with imaging methods (high-resolution photography, infrared reflectography and X-ray radiography) and non-invasive analytical techniques (MA-XRF and Raman spectroscopy). The results obtained for nine oil paintings produced from 1928 to 1958 are discussed in terms of the support, the preparatory layer, the preparatory drawing, the changes in composition and reuse of paintings, the pictorial layer and the dripping phenomenon.
Colored Shading Nets Differentially Affect the Phytochemical Profile, Antioxidant Capacity, and Fruit Quality of Piquin Peppers (Capsicum annuum L. var. glabriusculum)
Authors: Jiménez-Viveros Yamir , Valiente-Banuet Juan Ignacio
Published: November 2023

Piquin pepper fruits, a semi-domesticated wild pepper species highly valued in Mexico, currently face the threat of unsustainable harvesting practices that endanger the species. For this reason, it is necessary to establish sustainable agricultural practices for the cultivation of these peppers. Solar radiation, a critical determinant in crop production, plays a crucial role in plant development, influencing a spectrum of physiological and morphological processes, including the synthesis of phytochemicals. Our study evaluated the effect of light manipulation through colored shading nets on the phytochemical profile, antioxidant capacity, and fruit quality of semi-domesticated piquin peppers at two maturation stages: immature and mature (green and red fruits). Our hypothesis posits that these shading treatments may induce changes in these fruits’ phytochemical composition and antioxidant properties, as well as quality. Our results indicate that the shading treatments and maturity stage have significant on capsaicinoid and carotenoid levels, with the highest levels observed in mature fruits. Notably, red fruits grown under black shading treatments resulted in the highest capsaicinoid levels. Carotenoid levels were higher in the black shading treatment during the first cycle, while in the second cycle, the blue shading treatment showed elevated carotenoid levels, suggesting that high irradiance conditions could reduce carotenoid contents. Although no significant differences were observed among the treatments in green fruits, in red fruits, both black and blue treatments exhibited the highest total phenolic compounds in both production cycles. Furthermore, the antioxidant capacity revealed that red fruits exhibited higher antioxidant levels than green fruits. Color analysis showed that red fruits had higher chroma and hue angle values, indicating their brighter and more intense red color than green fruits. The morphological changes in fruit width, length, and weight can be attributed to shading treatments and maturation stages. These results indicate the potential of piquin peppers to act as rich sources of bioactive compounds, emphasizing the benefits of shading as an effective strategy to improve the quality and quantity of phytochemical compounds in piquin peppers. Our findings provide substantial insights into the intricate relationship between maturation, shading treatments, and phytochemical composition, offering a path to improve the nutritional value and quality of piquin peppers.
Differences in Physiological Characteristics of Green Prickly Ash Germplasm Resources in Response to Low-Temperature Stress
Authors: Shi Lin , Dong Xixi , Fu Hao , Chai Xingying , Bao Shuqin , Ren Yun , Hu Kai , Li Qiang , Chen Zexiong
Published: November 2023

In this study, we investigated the physiological response to low-temperature stress and comprehensively evaluated the cold resistance of green prickly ash germplasms. One-year-old branches of 23 green prickly ash varieties were used as experimental materials, three branches were selected from each variety, and three replicates of single branches were established. Subsequently, the physiological responses of the 23 green prickly ash germplasm resources to low-temperature stress were analyzed based on the relative conductivity (REC), osmotic adjustment substances, and antioxidant enzyme activities. We found that as the temperature decreased, the REC of each germplasm increased. The most rapid REC increase occurred from 0 to −10 °C and continued to gradually gently increase from −10 to −30 °C. The lethal dose-50 temperature (LT50) of the germplasms was between 3.16 and −12.37 °C. The top three cold-resistant varieties were TJ, SCHJ, and CJ, and the last three cold-resistant varieties were EWJ, DYSJ, and HYXJ. The results of a correlation analysis revealed a significant correlation between superoxide dismutase (SOD) activity and REC, between REC and free protein, and between SOD activity and catalase. The results of the PCA revealed that the first category includes 5 pepper varieties of CJ, LFJ, and XYTJ with higher cold-resistance score indexes; the second category includes 13 pepper varieties of YQ2 H, WCFZ, and TZJ with appropriate scores; and the third category includes 5 pepper varieties of HYXJ, HNJ, and DYSJ with lower scores. Cluster analysis was performed to classify the cold-resistance physiological indices, and four groups were obtained. The most cold-resistant groups included CJ and LFHJ, whereas the most cold-sensitive groups included HYXJ, DYSJ, and HNJ. Finality, the subordinate function method was used to determine the cold resistance from strong to weak. The varieties with the strongest cold resistance were LFJ, EWJ, and CJ, and the weakest varieties were DYSJ, YQ1H, and HYXJ. The strongest cold-resistant varieties were LFHJ and CJ, followed by DYSJ, YQ1H, and HYXJ. Based on multiple lines of evidence, the most cold-resistant varieties were CJ and LFJ, while the most cold-sensitive varieties were DYSJ and HYXJ. In conclusion, in this study, we elucidated the low-temperature tolerance of different varieties of green prickly ash, and varieties with high cold resistance were selected. These findings provide theoretical guidance and technical support for the screening of cold-resistant green prickly ash germplasms, which will facilitate their introduction to northern China.
Physiological and Molecular Responses of Camellia oleifera Seedlings to Varied Nitrogen Sources
Authors: Wang Rui , He Zhilong , Zhang Ying , Zhang Zhen , Wang Xiangnan , Chen Yongzhong
Published: November 2023

Camellia oleifera Abel. is a unique woody edible oil tree species in China mainly distributed in red soil areas. Nitrogen is one of the important growth-limiting factors for C. oleifera, and the nitrogen form has a vital impact on the growth and development of the plants. Ammonium and nitrate are the two nitrogen forms that are maximally absorbed and utilized by the plants. Here, we used one-year-old seedlings of the main varieties of C. oleifera (‘Xianglin No. 1’, ‘Xianglin No. 27’, and ‘Xianglin No. 210’) to set up six experimental groups treated with different nitrogen forms ([NO3−:NH4+] 0:0, 10:0, 7:3, 5:5, 3:7, and 0:10) and investigated the effects of nitrogen on the vegetative growth and photosynthetic characteristics of the seedlings. This study showed that mixed nitrogen sources could significantly increase the seedling height, ground diameter, biomass accumulation, and photosynthesis efficiency. Transcriptome sequencing analysis led to the identification of 3561 differentially expressed genes in the leaves. Preliminary screening identified several key enzyme genes from nitrogen nutrient metabolic pathways that were differentially expressed among seedlings grown with different nitrogen forms, and their expression pattern changes were further characterized. All the results demonstrate that the same proportion of ammonium nitrate ratio promoted the expression of genes encoding glutamine synthetase and glutamate synthase, thereby improving nitrogen assimilation and utilization efficiency. This study could provide a theoretical basis for scientific and rational fertilization and the improvement of nitrogen utilization efficiency in C. oleifera seedlings.
Structural, Familial, and Psychosocial Factors Affecting Long-Term Antiretroviral Treatment Adherence amongst Adolescents Living with Perinatally Acquired HIV in Limpopo, South Africa
Authors: Mabasa Rirhandzu Austice , Madiba Sphiwe , Mothiba Tebogo Maria
Published: November 2023

After more than two decades of the expansion of antiretroviral treatment (ART) in adolescents living with perinatal HIV (APHIV) in sub-Saharan Africa, there is still poorly sustained long-term adherence to ART due to multifactorial factors with the consequence of increased mortality and morbidity. There are little data available on the familial and structural factors which affect sustenance to long-term adherence to ART. A qualitative exploratory design was used to conduct in-depth interviews with 21 APHIV attending HIV care and management in the rural health facilities of Vhembe district in Limpopo Province, South Africa. Transcripts were translated verbatim into English, and data were analyzed using Tesch’s eight steps of qualitative data analysis. The sample consisted of APHIV 10–19 years old who were aware of their HIV status, and all had received ART for more than 5 years. They lived in extended, disrupted, grandparent- and child-headed households. They experienced food insecurities due to poverty or orphanhood, as well as living in disrupted households, which deterred them from long-term adherence. In addition, dependency on social support grants to sustain their livelihoods affected long-term adherence. APHIV had challenges with structural factors such as inconsistent clinic attendance, clashes between school activities and clinic appointments, and the lack of transport fare to the clinic, which affected adherence. Although APHIV were on one-pill fixed-dose ART, they were not able to sustain long-term adherence due to various familial, structural, and psychosocial challenges. In addition to institution-based interventions, there is a need for family, community-based, and multi-sectorial interventions to support long-term ART adherence among APHIV.
The Relationship between Wellbeing, Self-Determination, and Resettlement Stress for Asylum-Seeking Mothers Attending an Ecosocial Community-Based Intervention: A Mixed-Methods Study
Authors: Wu Yufei Mandy , Kreitewolf Jens , Kronick Rachel
Published: November 2023

Psychosocial support programs have been increasingly implemented to protect asylum seekers’ wellbeing, though how and why these interventions work is not yet fully understood. This study first uses questionnaires to examine how self-efficacy, satisfaction of basic psychological needs, and adaptive stress may influence wellbeing for a group of asylum-seeking mothers attending a community-based psychosocial program called Welcome Haven. Second, we explore mothers’ experiences attending the Welcome Haven program through qualitative interviews. Analysis reveals the importance of relatedness as a predictor of wellbeing as well as the mediating role of adaptive stress between need satisfaction and wellbeing. Further, attending Welcome Haven is associated with reduced adaptive stress and increased wellbeing, which correspond with the thematic analysis showing that attendance at the workshops fostered a sense of belonging through connection with other asylum seekers and service providers as well as empowerment through access to information and self-expression. The results point to the importance of community-based support that addresses adaptive stress and the promotion of social connection as key determinants of wellbeing. Nonetheless, the centrality of pervasive structural stressors asylum seekers experience during resettlement also cautions that relief offered by interventions may be insufficient in the face of ongoing systemic inequality and marginalization.
Beam Test of the First Prototype of SiPM-on-Tile Calorimeter Insert for the EIC Using 4 GeV Positrons at Jefferson Laboratory
Authors: Arratia Miguel , Bagby Bruce , Carney Peter , Huang Jiajun , Milton Ryan , Paul Sebouh J. , Preins Sean , Rodriguez Miguel , Zhang Weibin
Published: November 2023

We recently proposed a high-granularity calorimeter insert for the Electron-Ion Collider (EIC) that uses plastic scintillator tiles read out by SiPMs. Among its features are an ASIC-away-from-SiPM strategy for reducing cooling requirements and minimizing space use, along with employing 3D-printed frames to reduce optical crosstalk and dead areas. To evaluate these features, we built a 40-channel prototype and tested it using a 4 GeV positron beam at Jefferson Laboratory. The measured energy spectra and 3D shower shapes are well described by simulations, confirming the effectiveness of the design, construction techniques, and calibration strategy. This constitutes the first use of SiPM-on-tile technology in an EIC detector design.
Optic Disc Swelling in Cancer Patients: Etiology and Implications
Authors: Yousef Yacoub A. , Sid Ahmed Isra M. , Kanj Ahmad Danah , Mohammad Mona , Makahleh Hala , AlJabari Reem , Alkhatib Fawzieh , Toro Mario Damiano , Rejdak Robert , Mehyar Mustafa , Alnawaiseh Ibrahim
Published: November 2023

Purpose: To analyze the etiology and implications of optic disc swelling in cancer patients treated at a specialized tertiary cancer center in Jordan. Methods: This was a retrospective study of all cancer patients who had optic disc swelling between January 2019 and December 2020 at King Hussein Cancer Center (KHCC). Patients’ data included age, sex, laterality, visual acuity, and the underlying cause and management for the optic disc swelling. Results: Optic disc swelling was present in 58 cancer patients (96 eyes), with 38 (65%) having bilateral involvement. Among these, 33 (57%) were female, and 43 (74%) were ≤40 years old. At diagnosis, 58 (63%) eyes had a best-corrected visual acuity (BCVA) better than 0.5, improving to 73 (76%) eyes at the last follow-up. High intracranial pressure (ICP) was the most common primary cause (30 patients/52%), followed by tumor infiltration of the optic nerve (10 patients/17%), optic nerve compression (7 patients/12%), and optic nerve inflammation (5 patients/9%). Four patients had pseudopapilledema. Among the 30 patients with high ICP, CNS tumors were predominant (21 patients/70%), with only 3 having idiopathic intracranial hypertension. Medications, including ATRA (All-Trans Retinoic Acid) and systemic steroids, contributed to increased ICP in six patients (20%). BCVA was less than 0.5 in all eyes (100%) affected by tumor infiltration, optic nerve inflammation, and ischemic optic neuropathy, while only eight eyes (14%) with optic disc swelling due to elevated ICP had a BCVA less than 0.5 (p < 0.0001). Management included steroids (53 patients/91%), acetazolamide (30 patients/52%), chemotherapy (20 patients/34%), radiation therapy (13 patients/22%), frequent lumbar punctures (12 patients/21%), and surgery (28 patients/48%). Visual acuity improved in 40 eyes (42%), with only 4 eyes (4%) experiencing deterioration. At a 12-month median follow-up period, 11 (19%) patients were dead, 10 (10%) eyes had poor vision (BCVA less than 0.1), and 21 (22%) eyes had BCVA 0.5 or better. Conclusions: Various underlying pathologies can induce optic disc swelling in cancer patients, a grave condition capable of causing vision loss. Notably, tumor infiltration of the optic nerve tends to result in more profound visual impairment compared to papilledema due to elevated ICP. Timely detection is crucial, and immediate symptomatic treatment followed by addressing the underlying cause is essential to prevent irreversible optic nerve damage and vision loss in cancer patients.
Intravenous Diuresis in Severe Precapillary Pulmonary-Hypertension-Related Right Heart Failure: Effects on Renal Function and Blood Pressure
Authors: Labrada Lyana , Romero Carlos , Sadek Ahmed , Belardo Danielle , Raza Yasmin , Forfia Paul
Published: November 2023

In patients with right heart failure (RHF) and pulmonary hypertension (PH), classical teaching often advises cautious diuresis in the setting of ‘preload dependence’ to avoid renal injury and hemodynamic compromise. However, while this physiology may hold true in some clinical settings, such as acute ischemia with right ventricular infarction, it cannot necessarily be extended to PH-related RHF. Rather, in patients with precapillary PH and decompensated RHF, diuresis aimed to decongest the right heart and systemic venous system may be directly beneficial. This study aimed to evaluate the effects of diuresis on renal function and blood pressure in patients with severe precapillary PH. A retrospective chart review was conducted on 62 patients with severe precapillary PH admitted for decompensated RHF. The hemodynamic phenotype of these patients was characterized by invasive hemodynamics and echocardiographic data. Laboratory and hemodynamic data were collected at both admission and discharge. After large-volume diuresis in this patient population, there was an improvement in both glomerular filtration rate and creatinine. While there was a decline in blood pressure after diuresis, this was not clinically significant, given the blood pressure remained in a normal range with improvement in renal function. In conclusion, this study demonstrated that despite concern for preload dependence, significant diuresis in patients with acute decompensated RHF from precapillary PH is not only safe but beneficial.
Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties
Authors: He Jiayu , Liu Yuandong , Zeng Xiaofeng , Tong Yan , Liu Run , Wang Kan , Shangguan Xiangdong , Qiu Guanzhou , Sipaut Coswald Stephen
Published: November 2023

Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from common production methods. SEM and pore distribution analysis revealed the microstructure of microwave-sintered silicon nitride with obvious pores. Mechanical performance analysis shows that microwave sintering can improve the mechanical properties of silicon nitride. The CCK-8 method was used to demonstrate that microwave-sintered silicon nitride has no cytotoxicity and good cytocompatibility. From SEM and CLSM observations, it was observed that there was good adhesion and cross-linking of cells during microwave-sintered silicon nitride, and the morphology of the cytoskeleton was good. Microwave-sintered silicon nitride has been proven to be non-cytotoxic. In addition, the antibacterial ability of microwave-sintered silicon nitride against Staphylococcus aureus and Escherichia coli was tested, proving that it has a good antibacterial ability similar to the silicon nitride prepared by commonly used processes. Compared with silicon nitride prepared by gas pressure sintering technology, microwave-sintered silicon nitride has excellent performance in mechanical properties, cell compatibility, and antibacterial properties. This indicates its enormous potential as a substitute material for manufacturing bone implants.
Analysis of the Wave Attenuating and Dynamic Behaviour of a Floating Breakwater Integrating a Hydro-Pneumatic Energy Storage System
Authors: Cutajar Charise , Sant Tonio , Farrugia Robert N. , Buhagiar Daniel
Published: November 2023

Floating breakwaters have recently been generating increasing interest as a vital means to provide shelter and protect the ever-increasing number of structures deployed at sea. Notwithstanding the novel ideas being put forward, to date, floating breakwater deployment has been limited to inshore and shallow water areas. The scale of such structures has been restricted to the smaller spectrum. Furthermore, whilst some concepts to integrate floating breakwaters with other offshore systems have been proposed to benefit from cost-sharing strategies, studies related to floating breakwaters integrating energy storage are lacking in the open literature. The present research investigates the wave attenuating and dynamic performance of a large-scale floating breakwater in deep seas with a hydro-pneumatic energy storage system also integrated within the structure. This article highlights the arising need for floating breakwaters and sheds light on the present-day technological status of floating wave breakers. It then lays the ground for the proposed, novel floating breakwater concept that aims to address the current knowledge gaps in this field of study. The simulation results generated from numerical modelling via the potential flow solver ANSYS® AQWA™ have been promising, connoting that the addition of hydro-pneumatic energy storage to a floating breakwater will not lead to a degradation in the dynamic performance or wave breaking efficiency of the floating structure.
The Plant Defensin Ppdef1 Is a Novel Topical Treatment for Onychomycosis
Authors: van der Weerden Nicole L. , Parisi Kathy , McKenna James A. , Hayes Brigitte M. , Harvey Peta J. , Quimbar Pedro , Wevrett Sean R. , Veneer Prem K. , McCorkelle Owen , Vasa Shaily , Guarino Rosemary , Poon Simon , Gaspar Yolanda M. , Baker Michael J. , Craik David J. , Turner Rob B. , Brown Marc B. , Bleackley Mark R. , Anderson Marilyn A.
Published: November 2023

Onychomycosis, or fungal nail infection, causes not only pain and discomfort but can also have psychological and social consequences for the patient. Treatment of onychomycosis is complicated by the location of the infection under the nail plate, meaning that antifungal molecules must either penetrate the nail or be applied systemically. Currently, available treatments are limited by their poor nail penetration for topical products or their potential toxicity for systemic products. Plant defensins with potent antifungal activity have the potential to be safe and effective treatments for fungal infections in humans. The cystine-stabilized structure of plant defensins makes them stable to the extremes of pH and temperature as well as digestion by proteases. Here, we describe a novel plant defensin, Ppdef1, as a peptide for the treatment of fungal nail infections. Ppdef1 has potent, fungicidal activity against a range of human fungal pathogens, including Candida spp., Cryptococcus spp., dermatophytes, and non-dermatophytic moulds. In particular, Ppdef1 has excellent activity against dermatophytes that infect skin and nails, including the major etiological agent of onychomycosis Trichophyton rubrum. Ppdef1 also penetrates human nails rapidly and efficiently, making it an excellent candidate for a novel topical treatment of onychomycosis.
Structural and Functional Alterations Caused by Aureobasidin A in Clinical Resistant Strains of Candida spp.
Authors: Rollin-Pinheiro Rodrigo , de Moraes Daniel , Bayona-Pacheco Brayan , Curvelo Jose , dos Santos-Freitas Giulia , Xisto Mariana , Borba-Santos Luana , Rozental Sonia , Ferreira-Pereira Antonio , Barreto-Bergter Eliana
Published: November 2023

Candida species are one of the most concerning causative agents of fungal infections in humans. The treatment of invasive Candida infections is based on the use of fluconazole, but the emergence of resistant isolates has been an increasing concern which has led to the study of alternative drugs with antifungal activity. Sphingolipids have been considered a promising target due to their roles in fungal growth and virulence. Inhibitors of the sphingolipid biosynthetic pathway have been described to display antifungal properties, such as myriocin and aureobasidin A, which are active against resistant Candida isolates. In the present study, aureobasidin A did not display antibiofilm activity nor synergism with amphotericin B, but its combination with fluconazole was effective against Candida biofilms and protected the host in an in vivo infection model. Alterations in treated cells revealed increased oxidative stress, reduced mitochondrial membrane potential and chitin content, as well as altered morphology, enhanced DNA leakage and a greater susceptibility to sodium dodecyl sulphate (SDS). In addition, it seems to inhibit the efflux pump CaCdr2p. All these data contribute to elucidating the role of aureobasidin A on fungal cells, especially evidencing its promising use in clinical resistant isolates of Candida species.
Anterior Open Bite Malocclusion: From Clinical Treatment Strategies towards the Dissection of the Genetic Bases of the Disease Using Human and Collaborative Cross Mice Cohorts
Authors: Lone Iqbal M. , Zohud Osayd , Midlej Kareem , Paddenberg Eva , Krohn Sebastian , Kirschneck Christian , Proff Peter , Watted Nezar , Iraqi Fuad A.
Published: November 2023

Anterior open bite malocclusion is a complex dental condition characterized by a lack of contact or overlap between the upper and lower front teeth. It can lead to difficulties with speech, chewing, and biting. Its etiology is multifactorial, involving a combination of genetic, environmental, and developmental factors. Genetic studies have identified specific genes and signaling pathways involved in jaw growth, tooth eruption, and dental occlusion that may contribute to open bite development. Understanding the genetic and epigenetic factors contributing to skeletal open bite is crucial for developing effective prevention and treatment strategies. A thorough manual search was undertaken along with searches on PubMed, Scopus, Science Direct, and Web of Science for relevant studies published before June 2022. RCTs (clinical trials) and subsequent observational studies comprised the included studies. Orthodontic treatment is the primary approach for managing open bites, often involving braces, clear aligners, or other orthodontic appliances. In addition to orthodontic interventions, adjuvant therapies such as speech therapy and/or physiotherapy may be necessary. In some cases, surgical interventions may be necessary to correct underlying skeletal issues. Advancements in technology, such as 3D printing and computer-assisted design and manufacturing, have improved treatment precision and efficiency. Genetic research using animal models, such as the Collaborative Cross mouse population, offers insights into the genetic components of open bite and potential therapeutic targets. Identifying the underlying genetic factors and understanding their mechanisms can lead to the development of more precise treatments and preventive strategies for open bite. Here, we propose to perform human research using mouse models to generate debatable results. We anticipate that a genome-wide association study (GWAS) search for significant genes and their modifiers, an epigenetics-wide association study (EWAS), RNA-seq analysis, the integration of GWAS and expression-quantitative trait loci (eQTL), and micro-, small-, and long noncoding RNA analysis in tissues associated with open bite in humans and mice will uncover novel genes and genetic factors influencing this phenotype.
History of Pica, Obesity, and Their Associations with Anemia in Pregnancy: A Community-Based Cross-Sectional Study
Authors: Ali Suhaila A. , Hassan Ahmed A. , Adam Ishag
Published: November 2023

Anemia in pregnancy represents a major global health problem, and progress is insufficient to meet the World Health Assembly’s global nutrition target of halving anemia prevalence by 2030. We assessed the prevalence and factors associated with anemia among pregnant women in northern Sudan. This community-based cross-sectional study was conducted at Almatamah, River Nile State, Sudan. Sociodemographic and obstetric data were collected using a questionnaire. Hemoglobin (Hb) was measured using an automated hematology analyzer. Multivariate and simple linear regression analyses were performed. A total of 586 pregnant women were enrolled. Their median (interquartile range, IQR) age was 25 (21–30) years. The median (IQR) of body mass index (BMI) was 26.67 (24.34–30.04) kg/m2. The median (IQR) for Hb was 11.0 (10.0–11.9) g/dL. Of the 586 women, 271 (46.2%) had anemia (Hb: <11 gm/dL). In multivariate analysis, increasing BMI and obesity were significantly associated with decreased odds ratios (ORs) of anemia, while pica was associated with increased ORs of anemia. In conclusion, anemia in pregnant women is a major public health problem, as approximately half of pregnant women in northern Sudan have anemia. Increasing BMI and obesity were associated with a lower risk for anemia. More efforts are needed to improve the maternal nutritional status for good pregnancy outcomes.
Modeling Hospital Operating Theater Services: A System Dynamics Approach
Authors: Rahman Md Mahfuzur , Karim Rubayet , Moniruzzaman Md. , Hossain Md. Afjal , Younes Hammad
Published: November 2023

Background: A hospital’s operating theater service system is a large-scale, complicated system that must be carefully managed to offer the best possible results for its patients. Unlike other industries such as manufacturing and logistics, system dynamics (SD) methodologies are not extensively applied in hospital operating theaters. This study deals with the future development and possible future scenarios for hospital operating rooms in Bangladesh. Methods: Due to demographic dynamics and demographic processes, increased pressures on hospital care are expected in Bangladesh. The SD model anticipates possible future scenarios, reconciles service capacities and the variability of patient demand, and reduces patient congestion and waiting times in the hospital area. This study introduces a causal loop diagram to show a causal link between the hospital operating theater system variables. It also introduces a stock flow diagram to understand the dynamic behavior of the system. Results: The model validation testing reports that in extreme conditions, such as a 50% reduction in the patient arrival rate, the model is valid and runs as usual. Conclusions: This first work of SD modeling for hospital operating theater systems can help healthcare managers, decision makers, or researchers of any responsibility level make better predictions in order to reduce patient waiting times and backlogs and make appropriate decisions.
Mechanical Properties and Microscopic Mechanism of a Multi-Cementitious System Comprising Cement, Fly Ash, and Steel Slag Powder
Authors: Zhang Yuzhi , Zhang Shujing , Nie Qingke , Shen Liang , Wang Wei
Published: November 2023

The objective of this study was to reduce the stockpile of steel slag, which is a solid waste generated in the steelmaking process, and promote the resource utilization of steel slag powder (SSP) in construction projects. Experimental research was conducted on SSP and fly ash (FA) as supplementary cementitious materials. Composite cement paste samples were prepared to investigate the effects of the water-to-binder ratio and cement-substitution rate on the macroscopic mechanical properties, including the setting time, fluidity, flexural strength, and compressive strength of the prepared paste. The mineral composition in the raw materials was measured using X-ray diffraction (XRD), and a micro-morphological and structural analysis of the hydrated cementitious material samples was performed using scanning electron microscopy (SEM); the SEM and Image Pro Plus (IPP) image analysis techniques were combined for a quantitative analysis of the microstructure. The results showed that the addition of FA and SSP delayed the hydration of cement, thereby improving the flowability of the composite paste. Under the same curing age and cement substitution rate, the sample strength decreased with increasing water-to-binder ratio. Under the same water-to-binder ratio and curing age, the variations in the flexural and compressive strengths of the SSP group samples were inconsistent in the early and later stages, and the sample group with 20% SSP exhibited optimal mechanical strength in the later stage. The microscopic results showed that the needle-like AFt crystals in the hydrated pores decreased in number with the increase in the SSP content. The hydration products of the FA–SSP admixture, such as C–S–H gel and RO phase, acted as pore fillers in alkaline environments. When the water-to-binder ratio was 0.4 and the FA-to-SSP ratio was 1:1 to replace 40% cement, the performance of the hardened cement paste was the best among all the test groups containing both FA and SSP. This study provides a theoretical basis for the practical application of SSP and FA as cementitious materials in construction-related fields.
Ferroelectric Resistance Switching in Epitaxial BiFeO3/La0.7Sr0.3MnO3 Heterostructures
Authors: Qi Hongyan , Wu Weixin , Chen Xinqi
Published: November 2023

BiFeO3/La0.7Sr0.3MnO3 (BFO/LSMO) epitaxial heterostructures were successfully synthesized by pulsed laser deposition on (001)-oriented SrTiO3 single-crystal substrates with Au top electrodes. Stable bipolar resistive switching characteristics regulated by ferroelectric polarization reversal was observed in the Au/BFO/LSMO heterostructures. The conduction mechanism was revealed to follow the Schottky emission model, and the Schottky barriers in high-resistance and low-resistance states were estimated based on temperature-dependent current–voltage curves. Further, the observed memristive behavior was interpreted via the modulation effect on the depletion region width and the Schottky barrier height caused by ferroelectric polarization reversal, combining with the oxygen vacancies migration near the BFO/LSMO interface.
Molecular Dynamics Simulation and Viscosity Analysis of Red Mud–Steel Slag Glass–Ceramics
Authors: Tan Wenjie , Sun Tao , Ma Fukun , Jing Min , Liu Liqiang
Published: November 2023

The preparation of glass–ceramics with red mud and steel slag can not only solve the pollution problem caused by industrial waste slag but also produce economic benefits. It is difficult to analyze the high-temperature melt with the existing test methods, so the simulation experiment with molecular dynamics calculation becomes an important research method. The effects of steel slag content on the microstructure of red mud glass–ceramics were studied by molecular dynamics method. The results show that the binding ability of Si-O, Al-O, and Fe-O decreases with the increase in steel slag content. The number of Si-O-Si bridge oxygen increased gradually, while the number of Al-O-Al, Al-O-Fe, and Fe-O-Fe bridge oxygen decreased significantly. The number of tetrahedrons [SiO4] increased, the number of tetrahedrons [FeO4] and [AlO4] decreased, and the total number of three tetrahedrons decreased. The mean square displacement value of Si4+ and O2− increases first and then decreases, resulting in the viscosity of the system decreasing first and then increasing. The molecular dynamics method is used to analyze the structure of red mud–steel slag glass–ceramics on the microscopic scale, which can better understand the role of steel slag and has guiding significance for the experiment of this kind of glass–ceramics.