bluuebunny/crossref_metadata_2025 huggingface dataset:
ROLE OF CASSIA OCCIDENTALIS IN THALASSEMIC PATIENTS
Authors: N. Farooq
Published: July 2023

Effect of the leaves suspension of Cassia occidentalis on the elimination of excess of iron from the artificially iron overloaded rabbits was studied. Leaves suspension of C. occidentalis (250mg/kg) were used for the elimination of iron from iron overloaded rabbits. Rabbits were divided into three groups; overloaded for five weeks and then treated with selected herb for four weeks. Iron concentrations in serum and body organs like heart, liver and kidneys were assayed in all groups of rabbits after iron overloading with jectosol plus injections as per dose of 0.3 ml (15 mg iron) per kg body weight intramuscularly daily for 5 weeks. There was a significant increase in iron concentration in the sera and organs studied. In iron overloaded animals changes, like loss of weight, loss of hair, loss of activity and increased heart rate were observed. After four weeks of herbal treatment (250mg/kg), there was a significant decrease in iron concentration in the serum and organs as compared with iron overloaded untreated with herb group. The decrease was more significant in kidneys and liver as compared to the heart. It was concluded that C. occidentalis leaves suspension was significantly effective in reducing the iron level from serum and organs studied
TRADITIONAL PLANTS OF FAMILY SOLANACEAE FACING THE PROBLEM OF ADULTERATION: A CRITICAL ISSUE
Authors: S. Shaheen
Published: July 2023

Authenticated identification of medicinal plants always had been an issue because of their local names misunderstanding and multiple morphological similarities. Hence the present study was an effort to provide some authenticated taxonomic tools for identification of three valuable selected medicinal plants of the family Solanaceae. i.e., Datura stramonium L., Solanum nigrum L. and Withania somnifera L. This study was based on multiple parameters (morphology, anatomy (Light Microscopy & Scanning electron microscopy), palynology (LM & Scanning Electron Microscopy), Organoleptography, UV (ultra violet) and IR (infra-red) analysis, solubility, fluorescence and chemical analysis, so as to establish some reiliable taxonomic tools for recognition of these plants. Anatomical studies were carried out to identify the species from the taxonomic point of view. A variety of characters like epidermal cells, subsidiary cells, guard cells, trichomes, macro-hairs, micro-hairs and stomata were used as a tool for the taxonomic grouping of different species. Pollen characters in all the three taxa were helpful to distinguish the taxa at species as well as at generic level. The organoleptic, ultra violet, infra red and chemical analysis of the taxa showed a lot of variation among them. The present research work provided a comprehensive detail of the systematics along with the pharmacognosy of selected taxa which can be used as an aid in the identification and exploration of the medicinal wealth of the Pakistan.
BIOREMEDIATION OF HEXAVALENT CHROMIUM BY FREE AND IMMOBILIZED BIOMASS OF CHLORELLA AND PSEUDOMONAS
Authors: S. Akram
Published: July 2023

Hexavalent chromium is a toxic heavy metal and carcinogen. The purpose of present study was to analyze Cr(VI) resistant bacterial strain S7 in combination with Cholera for observing the mutualistic relationship for remediation processes. By 16S rRNA sequencing technique, the strain S7 was identified to be Pseudomonas species (KR095629). It was able to tolerate Cr(VI) stress up to 600μg/mL and showed an optimum Cr(VI) reduction of 100μg/mL. Sodium alginate (2%) was used for immobilization of S7 and Chlorella. Chromium (VI) removal by immobilized cells of S7 and Chlorella was 4.5mg/g and 6.20mg/g, with reduction potential of 58% and 60%, respectively. A direct relation between Cr(VI) concentration and root length of Chlorella was observed. Maximum root length was observed for Chlorella and S7 i.e. 1.9cm at 500μg/ml Cr(VI) concentration. The presence of several absorption peaks in the Fourier transform infrared spectroscopy (FTIR) of the biomass indicated its complex nature. This technique revealed the involvement of hydroxyl group, N-H and C- O group. The Cr(VI) was effectively removed by bacterial strain when used with Chlorella.
FORMULATION OF A COST-EFFECTIVE MEDIUM TO SUPPORT HIGH BIOMASS PRODUCTION AND IMPROVED AMINO ACID PROFILE OF ARTHROSPIRA PLATENSIS
Authors: S. Ali
Published: July 2023

Arthrospiraplatensis is a WHO recognized super food. However, it is not extensively commercialized due to the high cost associated with its cultivation media. This study was designed to devise a cost effective media for the culturing of A. platensis. Standard Zarouk’s media (ZK) was used a reference media for nutrient composition to formulate six cost effective cultivation media (XR-1-XR- 6). Growth of A. platensis was analyzed on the basis of cell count, growth percentages and biomass production. Amino acid contents were determined through Amino Acid Analyzer. Growth of A. platensis cultivated in XR-1 and XR-3 media was observed comparable with ZK in terms of cell count and spiral structure The XR-3 medium formulated in this study was found to produce improved percent growth rate and amino acid content when compared with A. platensis cells grown inconventionally used Zarouk’s medium.
ELEVATION OF WHEAT CULTIVARS AT VARIOUS LEVELS OF NITROGEN THROUGH FIELD EXPERIMENTATION AND MODELING APPROACH IN PUNJAB, PAKISTAN
Authors: N. Ehsan
Published: July 2023

The present study was conducted to evaluate the growth of wheat cultivars at different nitrogen (N) levels through experimental and crop simulation model in Sialkot District of Punjab, Pakistan. The data was collected from the fields as well as the weather and soil data obtained from the relevant departments. The experiment was conducted for two wheat cultivars with four treatments of N i.e. 0, 55, 110, 220 kg N per hector. Overall, the results indicated that the field level observed data showed significantly positive correlation with the model simulated growth and yield variables. The findings of this study showed that out of the two wheat cultivars i.e. Faisalabad-2008 showed earlier anthesis and maturity as compared to the Sehar-2006, however, the wheat yield, leaf area index, and harvest index was higher for Sehar-2006. From these results, it can be concluded that Sehar-2006 has more productivity and must be encouraged as compared to Faisalabad-2008.
HISTOPATHOLOGICAL CHANGES IN THE UTERUS OF INFERTILE SLAUGHTERED BUFFALOES
Authors: M. Ihtisham ul huq  , A.A.Channa  , R.Yousaf  , N.Ullah  , R.Khan  , M.H.Ali  , G.Abbas  , B.Khan
Published: July 2023

Agribusiness is the foundation of Pakistan's economy as it contributes 18.9 percentto the nation's GDP. Buffalo is a significant investor with a populace of 38.8 million heads. Theprofitable characteristics of Nili Ravi wild ox are inimitable with some other buffalo breeds on theplanet, while the conceptive qualities are still nadir. The most widely recognized regenerative issuesexperienced are postponed time of pubescence, helpless estrus articulation, low ripeness with AI,deferred baby blues anestrous, and irregularity. These attributes have made it amazingly hard toincrease quick hereditary advancement in this variety. Conceptive biotechnologies assume a key job inbreed improvement by bypassing these obstacles. For this study eighty animals were selected andslaughtered due to reproductive issues and reproductive tracts were collected from the slaughterhouseand observe the tract grossly (texture and shape, any exudate, ovarian structures). Then cut the uterinetissue sample with the size of 2 × 2 × 2cm was fixed in formalin 10% for histopathology. Afterprocessing microscopy was performed to find histopathologic changes (Endometrial epithelium,uterine gland, and inflammatory cells and caruncles status). The grading of animals is labeled asNormal (-), Mild (+), Moderate (++), and Severe (+++) on basis of the degree of infection. The whiteside test was negative for 40% of samples while 60% of animals are positive with different degrees ofaffection. Endometrial epithelium erosion is absent in 31.43% of animals while 68.67% of animalshave erosions. Atrophy of uterine glands was absent in 41.43% of animals while 58.67% of animalscontained atrophy of glands. 11.43% of animals were negative for inflammatory cells while 88.66% ofanimals were positive for inflammatory cells. 20% of animals had normal caruncles while 80% ofanimals had swelled caruncles. Discharge was collected for the white side test from the cervix. 62.86%of animals had serious discharge while 37.14% of animals had a purulent discharge. The color andtexture of the tract are divided into two categories pale and pale reddish with swelling. 54.74% had apale color while 45.26% had a pale and reddish with swelling. In conclusion, 60% of animals wereaffected by endometritis including mild, moderate, and severe. Histopathological parameters and thenature of exudate also showed a significant relationship with endometritis which was indicated by thewhite side test. The treatment of endometritis should be done after the white side test beforeinsemination. In this way, we can improve reproductive performance and conception rate. Furtherstudies are warranted to perform the culture sensitivity test and treat the animals with intra-uterine andsystemic antibiotic therapy.
Fucik spectrum with weights and existence of solutions for nonlinear elliptic equations with nonlinear boundary conditions
Authors: Mavinga Nsoki , Morris Quinn A. , Robinson Stephen B.
Published: July 2023

We consider the boundary value problem $$\displaylines{ - \Delta u + c(x) u = \alpha m(x) u^+ - \beta m(x) u^- +f(x,u), \quad x \in \Omega, \cr \frac{\partial u}{\partial \eta} + \sigma (x) u =\alpha \rho (x) u^+- \beta \rho (x) u^- +g(x,u), \quad x \in \partial \Omega, }$$ where \((\alpha, \beta) \in \mathbb{R}^2\), \(c, m \in L^\infty (\Omega)\), \(\sigma, \rho \in L^\infty (\partial\Omega)\), and the nonlinearities f and g are bounded continuous functions. We study the asymmetric (Fucik) spectrum with weights, and prove existence theorems for nonlinear perturbations of this spectrum for both the resonance and non-resonance cases. For the resonance case, we provide a sufficient condition, the so-called generalized Landesman-Lazer condition, for the solvability. The proofs are based on variational methods and rely strongly on the variational characterization of the spectrum.
See also https://ejde.math.txstate.edu/special/02/m2/abstr.html
The sociocultural context of the evolution of career concept
Authors: Ornovetchii Tatiana
Published: July 2023

The professional field represents a relevant part in the existence of each individual. The profession is what defines us as personalities, as individuality, as an integral part of the society, as a progressive element in the social structure. Professional life evolves and develops simultaneously/in dependence of personal life, being a fundamental element for the well-being of the personal self, for personal inner comfort and for harmonious symbiosis between personal and professional. Developing a career is a long-lasting process and not a simple destination. Thus, career remains a central concept for any period of life and for any generation, a center of special interest for any area thanks to its theoretical and practical values, for understanding, explaining and proposing solutions in the sphere of professional occupation.
The dynamics of students’ reflection development
Authors: Rusov Veronica
Published: July 2023

The article deals the problem of higher education, which is marked by continuous modernization and innovation to the requirements of contemporary society, seeks solutions for the training/development of the subject quality of students as future professionals. Based on the conceptual analysis of the term „reflection”, the importance of reflexi-vity in ensuring student-centered higher education is argued. Empirical study of the dynamics of the development of reflexivity among students in the process of initial professional training in higher education highlighted the need to adapt reflective didactic technologies to the reflexive potential of students, which proved to be manifested differently during the years of study.
Condicionantes maternos asociados a efectos adversos por anestesia raquídea en gestantes sometidas cesárea en el hospital nacional Arzobispo Loayza, de enero a diciembre 2018, Lima
Authors:   , Mejía Arróstegui Félix Alfonso
Published: July 2023

Objetivo: Determinar acerca de los condicionantes maternos que se asociaron a efectos adversos por anestesia raquídea en gestantes sometidas a cesárea en el Hospital Nacional Arzobispo Loayza, de Enero a Diciembre de 2018. Metodología: Estudio observacional, analítico de casos y controles, corte transversal y retrospectivo. La muestra estuvo conformada por 126 gestantes sometidas a cesárea. Resultados: No se demostró significancia estadística entre las variables de estudio asociadas a efectos adversos por anestesia raquídea. En cambio, se encontró asociación significativa en las variables preeclampsia con criterios de severidad y enfermedad cardíaca, siendo un factor de riesgo asociado a efectos adversos por anestesia raquídea. Conclusiones: La preeclampsia con criterios de severidad y enfermedad cardiaca demostraron ser factores de riesgo asociados a efectos adversos por anestesia raquídea, siendo el más evidente la hipotensión arterial leve en gestantes cesareadas en el H. N. Arzobispo Loayza, de Enero a Diciembre 2018.
Factores de riesgo de cáncer de vesícula en pacientes del hospital nacional dos de mayo periodo. 2014– 2018
Authors:   , Gomez Hinostroza Steve Poul
Published: July 2023

Introducción: El cáncer ubicado en la Vesícula Biliar es considerada dentro de las neoplasias que presentan una alta consecuencia en el aspecto global del paciente, así mismo representa un 3% de los carcinomas y está ubicado en el 5to lugar de las neoplasias malignas del sistema digestivo. Objetivo: Determinar los factores de riesgo de cáncer de Vesícula en pacientes del hospital Nacional Dos de Mayo. Periodo 2014-2018. Métodos: Estudio observacional, Trasversal, retrospectivo, analítico, de casos y controles. La muestra estuvo conformada por 70 casos y 70 controles que se atendieron en la especialidad de cirugía general durante el periodo 2014 a 2018. Se estudió los factores de riesgo asociados al cáncer de vesícula; se recolecto data de las historias clínicas a través de fichas de recolección de datos, que posteriormente fue estudiada por el programa SPPS versión 25.0 usando la prueba estadística del chi cuadrado y odd ratios con un nivel de significancia p<0.005 y un intervalo de confianza de 95%. Resultado: El factor de riesgo asociado a cáncer de vesícula son los cálculos biliares (Or: 34.895, IC: 12.197-99.831, p: 0.000), en lo pólipos vesiculares no se encontró una asociación significativa (Or: 0.942, IC: 0.487- 1.856, p: 0.863) y en la obesidad se mostró como un factor protector (Or: 0.172, IC: 0.072- 0.413, p: 0.000). Conclusión: Se determina que hay una asociación estadísticamente significativa con los cálculos biliares y el cáncer vesicular.
“Nga-wayang”: A New Dance Creation from a Globalized Sociocultural Environment
Authors: Ari Sidiastini Ni Putu , Rai S I Wayan , Ruastiti Ni Made
Published: July 2023

This scientific article aims to discuss a new dance creation entitled “Nga-wayang”, whose creation idea depicts the character Gatot Kaca in a two-dimensional wayang kulit show. No one has worked on a dance that was transformed from a two-dimensional wayang kulit performance into a new three-dimensional dance creation. The creation of the “Nga-wayang” dance uses qualitative methods. The creation process is carried out in stages: ngarencana, nuasen, makalin, nelesin, and ngebah. The search for ideas was carried out using participatory observation techniques and in-depth interviews with related parties. The deepening of the character of Gatot Kaca's character is carried out through library research and discography. The process of creating this new dance creation is carried out using transformation theory and aesthetic theory. The cultivation of this work of art has resulted in a new dance creation entitled “Nga-wayang”. As a new dance creation, “Nga-wayang” is presented full of new ideas based on the influence of the art ecosystem in the influence of globalization in terms of poses, variety of movements, techniques, dynamics, tempo, and level play based on multimedia such as LCD projectors, LED lights, and smoke. The process of composing this dance has been carried out since this material was developed as a final choreography class assignment, the presentation of which has been continuously refined. “Nga-wayang” is a new dance creation that departs from the experience of the cultural environment in the era of globalization, namely the ecosystem as an art reinforcement.
Onthel Bicycle: Creation Model of Experimental Photography using Iwan Zahar Method
Authors: Kayansa I Made Dennis Penn Yohan , Wirakesuma I Nengah
Published: July 2023

In Indonesia, the development of bicycles was heavily influenced by the colonialists, especially the Dutch. They brought bicycles produced in their country to use around to enjoy the fresh nature of Indonesia. This habit was transmitted to the aborigines with blue blood. Finally, the bicycle became a prestigious means of transportation. Onthel bicycles were a means of transportation that were relatively expensive before the independence period. Onthel bicycles, also known as camel bicycles, kebo bicycles, or pit pancal, are standard bicycles with 28-inch tires that were commonly used by urban communities until the 1970s. The heritage factor and the classic shape of the bicycle are interesting to be used as an experimental bicycle photography work. Starting from this phenomenon, the authors argue that research related to bicycles is necessary and interesting to do because in the globalization or modern era which is full of modern lifestyle offers, bicycles actually choose a classic lifestyle.
MERANCANG NARASI DAN VISUAL UNTUK KOMIK FIKSI
Authors: Ramdhan Asep
Published: July 2023

Setiap orang tentu mempunyai cerita masing-masing selama hidupnya, bagi penulis cerita dalam hal ini seorang perancang komik, menyusun cerita bisa berdasarkan dari berbagai sumber inspirasi, baik itu dari pengalaman hidup yang dialami, berdasarkan dari kabar yang didengar dari orang lain, cerita dari hasil lamunan imajinasi maupun cerita dari hasil melihat, membaca, menonton dari media populer seperti buku, film dan internet. Menyusun cerita untuk komik hingga mencapai bentuk visual yang diharapkan, memiliki tantangan tersendiri. Dalam merancang komik, berangkat dari penyusunan narasi hingga visualisasi, setiap perancang komik profesional memiliki langkah yang berbeda-beda, yang pada akhirnya adalah untuk mencapai keterselesaian karya sesuai dengan deadline waktu yang ditetapkan oleh penerbit. Bagi seorang perancang komik pemula yang belum memiliki banyak pengalaman dalam merancang, tentu memerlukan informasi metode ringkas serta contoh tahapan bagaimana langkah-langkah yang harus dikerjakan untuk mencoba melahirkan karya komik yang komunikatif.

Kata kunci: komik, narasi, metode, fiksi
O Risco do Bordado: Desfazendo os Nós e Recosturando o Casamento
Authors: Zagne Ana Maria Oliveira , Kraichete Noemia , Engelhard Suely
Published: July 2023

Trabalho com casais, principalmente casais em risco, tendo o casamento como facilitador de diferenciação, pelo confronto, como no espelho, dos handicaps individuais. Através de entrevistas e vivências avaliamos até onde nós e tramas inconscientes das famílias de origem, que formam o risco do bordado, a planta baixa onde o casal vai fincar os alicerces da vida futura trazem: enriquecimento? Ou histórias de insatisfações, uma dança macabra aonde cada um vai se perdendo mais do que se achando no outro? No casamento em risco aparece um terceiro como sombra, o próprio sujeito casamento. Funcionando autonomamente, com vontades, desejos, mágoas, sintomas e complexos, e o casal passa a se relacionar com e através deste OUTRO. Viemos de nossa origem com traçados diferentes. Perceber que o outro não é uma ideia inscrita na minha cabeça, aquilo que desejo, permite ao casal transformações criativas e o encontro Eu-Tu sobrevive no Nós.
Kecerdasan Kultural (CI): Membangun Pendidikan Bermutu Total
Authors: Muda Hubertus
Published: July 2023

The article introduces the basic concept of “Cultural Intelligence" (CQ),a theoretical framework for evaluating effectiveness in intercultural interaction. Each of the four major components is decribed: Knowledge CQ (understanding cultural differences); Interpretive CQ(ability to interpret cues); Perseverance CQ(persevering though intercultural conflict) and behavioural CQ (acting appropriately).To help readers understand the practical implications of these categories, the article develops a recurring case example in Education. By describing some of their inaccurate assumptions and inappropriateness behaviours, a clear picture emerges ofhow CQ operates practically. Total Quality Education(TQE)based on Total Quality Management (TQM) very much count on how is Cultural Intelligence (Cl) put in practice regularly.
Apresentação Dossiê Vol. I
Authors: Barbalho Alexandre , Severino José Roberto
Published: July 2023

Apresentação Dossiê Cultura Alimentar e Política Cultural Vol. I
Practical experience commissioning MRI‐compatible tandem and ring applicators for use with the Bravos HDR afterloader
Authors: Fagerstrom Jessica M.
Published: July 2023

Five complete MR‐conditionally approved ring sets, including fifteen tandems, and two additional rings, were commissioned at an institution intending to use them in an MRI planning environment with a Bravos HDR brachytherapy remote afterloader. Channel length, radiograph, autoradiograph, ring offset, and treatment interrupt measurements were performed, and applicators were assessed in both CT and MRI. During commissioning, one ring was found to be defective and was returned to the manufacturer for a replacement. The eventual complete applicator suite (including the replacement ring) was found to follow the manufacturer‐provided specifications, including those delineated in vendor‐provided 3D virtual models and those defined within the manufacturer's instructions for use documentation. Based on this work, an offset correction of −0.4 cm will be used for all tested rings using the Bravos system's internal distal dwell position correction feature during treatment preparation. This study reiterated the requirement for careful commissioning of each applicator intended for clinical service considering the intended use and the planned clinical environment and work processes.
A Microfluidic Liquid Biopsy Platform to Monitor Protein Biomarker Heterogeneity in Single Circulating Therapy‐Resistance Cancer Cell
Authors: Ahmed Emtiaz , Shanmugasundaram Karthik Balaji , Li Junrong , Behren Andreas , Lobb Richard , Möller Andreas , Wuethrich Alain , Dey Shuvashis , Sina Abu Ali Ibn , Trau Matt
Published: July 2023

Tumor cells display heterogenous molecular signatures during the course of cancer and create distinct tumor cell subpopulations which challenge effective therapeutic decisions. Detection and monitoring of these heterogenous molecular events at single cell level are imperative to identify tumor cell subpopulations and to engage the best therapeutic options for the individual patient. Herein, a microfluidic liquid biopsy platform to analyze circulating tumor cells (CTCs) at single cell level is reported. The individual CTCs are captured in an alternating current‐induced microfluidic platform and analyzed by using surface‐enhanced Raman scattering spectroscopy. This platform selectively captures single CTCs from the patient's peripheral blood mononuclear cells. Using cell line models and patient samples, it is shown that the assay can simultaneously detect multiple protein biomarkers on a single CTC. The platform can stratify the CTCs into different subpopulations based on their cancer‐associated protein signature changes in response to drug treatment. This enables the identification of CTC subpopulations that are probably not responding to treatment and may assist clinicians in specifically monitoring and eliminating therapy‐resistant cancer cells within a lesion. This single CTC monitoring chip will likely have high clinical importance in disease diagnosis and treatment monitoring, and advance the knowledge of cancer heterogeneity.
Neoadjuvant S‐1 and oxaliplatin plus bevacizumab therapy for high‐risk locally advanced rectal cancer: A prospective multicenter phase II study
Authors: Miura Takuya , Morohashi Hajime , Sakamoto Yoshiyuki , Kagiya Takuji , Hasebe Tatsuya , Nakayama Yoshihito , Fujita Hiromasa , Hakamada Kenichi
Published: July 2023

Aim

We report the short/mid‐term results of surgery for high‐risk locally advanced rectal cancer (LARC) after neoadjuvant chemotherapy (NAC, four courses of S‐1 + oxaliplatin+ bevacizumab) without radiotherapy with the primary aim of ypT0‐2.

Methods

High‐risk LARC was defined as cT4b, mesorectal fascia (MRF) ≤1 mm (MRF+), or lateral lymph node metastasis (cLLN+) on high‐resolution MRI. The planned 32 cases from April 2018 to December 2021 were all included.

Results

There were 10 patients at cT4b (31.2%), 26 MRF+ (81.3%), and 22 cLLN+ (68.8%). Thirteen (40.6%) underwent NAC after a colostomy for stenosis. NAC was completed in 26 (81.2%) cases. Grade 3 or higher adverse events occurred in six (18.7%). One patient developed progressive disease (3.2%). Eleven were ycT0‐3MRF‐LLN‐ (34.3%). Curative‐intent surgery was performed on 31, with sphincter‐preserving surgery in 20, abdominoperineal resection in nine, total pelvic exenteration in two, and lateral lymph node dissection in 24. Two had R1/2 resection (6.4%). A Grade 3 or higher postoperative complication rate occurred in 3.2%. Pathological complete response and ypT0‐2 rates were 12.9% and 45.1%. Three‐year disease‐free survival rates (3yDFS) for ypT0‐2 and ypT ≥3 were 81.2%, 46.6% (p = 0.061), and 3‐year local recurrence rates (3yLR) were 0%, 48.8% (p = 0.015). 3yDFS for ycT0‐3MRF‐LLN‐ and ycT4/MRF+/LLN+ were 87.5%, 48.0% (p = 0.031) and 3yLR were 0%, 42.8% (p = 0.045).

Conclusion

NAC yielded a clinically significant effect in about half of high‐risk LARC patients. If NAC alone is ineffective, radiotherapy should be added, even if extended surgery is intended.
Cytoreductive surgery for synchronous and metachronous colorectal peritoneal dissemination: Japanese P classification and peritoneal cancer index
Authors: Mizumoto Akiyoshi , Takao Nobuyuki , Imagami Toru , An Byonggu , Oe Yasumitsu , Togawa Takeshi , Yonemura Yutaka
Published: July 2023

Aim

The outcomes of cytoreductive surgery (CRS) for synchronous and metachronous colorectal peritoneal dissemination were investigated using the Japanese P classification and peritoneal cancer index (PCI).

Methods

CRS was performed in 111 cases of synchronous peritoneal dissemination and 115 cases of metachronous peritoneal dissemination. The P classification and PCI were determined at the time of laparotomy.

Results

In the synchronous dissemination group, the 5‐year overall survival rates after CRS in P1/P2 and P3 cases were 51% and 13%, respectively. Even for P3, 51% of the patients achieved macroscopic cytoreductive complete resection (CC‐0), with a 5‐year survival rate of 40%. When P3 cases were classified into PCI 0–9, 10–19, 20–29, and 30–39, CC‐0 was achieved in 93%, 70%, 6%, and 0% of the cases, respectively, and the 5‐year survival rate of PCI 0–9 was 41%. In the metachronous dissemination group, the 5‐year survival rates were 62% for PCI 0–9 and 22% for PCI 10–19; 5‐year survival was not observed in patients with a PCI ≥ 20. CC‐0 was significantly associated with the postoperative prognosis in both synchronous and metachronous peritoneal dissemination.

Conclusion

In cases of synchronous dissemination, CRS must be performed for P1 and P2 cases or those with a PCI < 10, while detailed examination using PCI is required for P3 cases. In cases of metachronous dissemination, CRS should be considered when the PCI score is <20.
Synthesis of Enantioenriched 1,2‐cis Disubstituted Cycloalkanes by Convergent NiH Catalysis
Authors: Chen Changpeng , Guo Wenqing , Qiao Deyong , Zhu Shaolin
Published: July 2023

Enantioenriched multi‐substituted cycloalkanes constitute an essential class of compounds in pharmaceuticals, natural products and agrochemicals. Here we report an NiH‐catalyzed asymmetric migratory hydroalkylation process for the efficient and selective construction of such compounds. Through a dynamic kinetic asymmetric transformation (DYKAT), easily accessible racemic and isomeric mixtures of cycloalkenes could be directly utilized as starting materials, convergently producing thermo‐dynamically disfavored chiral 1,2‐cis disubstituted cycloalkanes bearing vicinal stereocenters with high levels of regio‐, diastereo‐ and enantioselectivity. In addition, prochiral cyclic alkenes can be also employed, and deliver chiral 1,2‐cis disubstituted cycloalkanes through desymmetrization process.
Gambogenic acid inhibits proliferation and ferroptosis by targeting the miR‐1291/FOXA2 and AMPKα/SLC7A11/GPX4 axis in colorectal cancer
Authors: Ma Xiaoqi , Xu Midie , Zhang Xing , Wang Xin , Su Kexin , Xu Zihang , Wang Xiaoyu , Yang Yifu
Published: July 2023

The present study aims to investigate the mechanism of the nature compound gambogenic acid (GNA) on the apoptosis and ferroptosis in colorectal cancer (CRC). The effect of GNA on the proliferation of CRC cell lines were detected by MTT and clonogenic assay. The xenograft tumor model was established, and the inhibition effect of GNA were evaluated by observing the tumor growth. The endoplasmic reticulum (ER) of HCT116 was observed by using the ER tracker. The TargrtScan database was used to predict the miRNA binding sites. The level of miRNA with GNA treatment was explored by real‐time quantitative PCR. The effect of ferroptosis were evaluated by detect the expression of reactive oxygen species (ROS), intracellular ferrous iron (Fe2+), malondialdehyde (MDA), glutathione (GSH), subunit solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase (GPX)4, transferrin, and ferritin by Western blot. GNA isolated from gamboge can inhibit the growth and proliferation of CRC cell lines in a concentration‐dependent manner. GNA activated ER stress by upregulating miR‐1291, and miR‐1291 targeted the forkhead box protein A2 (FOXA2). GNA also induced ROS production and mediated the Fenton reaction by activating transferrin to increase Fe2+, thus inducing ferroptosis. In addition, GNA could induce ferroptosis through the depletion of GSH and GPX4. Furthermore, GNA treatment regulated iron metabolism by activating AMPKα/SLC7A11/GPX4 signaling. In conclusion, GNA activated ER stress via miR‐1291 and induced ferroptosis in CRC cells and might be a new inducer of ferroptosis, which can expand the efficacy of chemotherapy drugs.
Fighting calcification with optical coherence tomography‐guided percutaneous coronary intervention. Commentary on the optical coherence tomography‐derived predictors of stent expansion in calcified lesions
Authors: Sonoda Shinjo , Node Koichi
Published: July 2023

Key Points

OCT derived coronary artery calcification assessment on requiring more aggressive lesion preparation is warranted.

The predictive ability of calcium angle, thickness, and presence of calcified nodule for absolute and relative stent expansion was limited, but only total calcium length remained a predictor.

Aggressive lesion preparation and the selection of appropriate balloon size for postdilatation under imaging guidance are necessary for fighting and overcoming calcified lesions.
Electrocautery‐assisted re‐entry to resolve bilateral aorto‐ostial chronic total occlusions due to leaflet obstruction following transcatheter aortic valve replacement
Authors: Kane Jesse , Kearney Kathleen E. , Lombardi William L. , Azzalini Lorenzo
Published: July 2023

Coronary artery obstruction is a rare but life‐threatening complication of transcatheter aortic valve replacement (TAVR). While urgent percutaneous coronary intervention has been described in cases of acute occlusion, little is known about the interventional management of obstruction once it has occurred in the chronic setting. We describe a case in which electrocautery‐assisted re‐entry was successfully utilized to manage the right coronary artery and left main chronic total occlusion due to leaflet‐induced coronary artery obstruction after TAVR.
Bifurcation left main stenting with or without intracoronary imaging: Outcomes from the EBC MAIN trial
Authors: Maznyczka Annette , Arunothayaraj Sandeep , Egred Mohaned , Banning Adrian , Brunel Philippe , Ferenc Miroslaw , Hovasse Thomas , Wlodarczak Adrian , Pan Manuel , Schmitz Thomas , Silvestri Marc , Erglis Andrejs , Kretov Evgeny , Lassen Jens Flensted , Chieffo Alaide , Lefevre Thierry , Burzotta Francesco , Cockburn James , Darremont Olivier , Stankovic Goran , Morice Marie‐Claude , Louvard Yves , Hildick‐Smith David ,   EBC MAIN (European Bifurcation Club Left Main Coronary Stent study) investigators
Published: July 2023

Background

The impact of intracoronary imaging on outcomes, after provisional versus dual‐stenting for bifurcation left main (LM) lesions, is unknown.

Objectives

We investigated the effect of intracoronary imaging in the EBC MAIN trial (European Bifurcation Club LM Coronary Stent study).

Methods

Four hundred and sixty‐seven patients were randomized to dual‐stenting or a stepwise provisional strategy. Four hundred and fifty‐five patients were included. Intravascular ultrasound (IVUS) or optical coherence tomography (OCT) was undertaken at the operator's discretion. The primary endpoint was death, myocardial infarction or target vessel revascularization at 1‐year.

Results

Intracoronary imaging was undertaken in 179 patients (39%; IVUS = 151, OCT = 28). As a result of IVUS findings, operators reintervened in 42 procedures. The primary outcome did not differ with intracoronary imaging versus angiographic‐guidance (17% vs. 16%; odds ratio [OR]: 0.92 (95% confidence interval [CI]: 0.51−1.63) p = 0.767), nor for reintervention based on IVUS versus none (14% vs. 16%; OR: 0.88 [95% CI: 0.32−2.43] p = 0.803), adjusted for syntax score, lesion calcification and ischemic symptoms. With angiographic‐guidance, primary outcome events were more frequent with dual versus provisional stenting (21% vs. 10%; adjusted OR: 2.11 [95% CI: 1.04−4.30] p = 0.039). With intracoronary imaging, there were numerically fewer primary outcome events with dual versus provisional stenting (13% vs. 21%; adjusted OR: 0.56 [95% CI: 0.22−1.46] p = 0.220).

Conclusions

In EBC MAIN, the primary outcome did not differ with intracoronary imaging versus none. However, in patients with angiographic‐guidance, outcomes were worse with a dual‐stent than provisional strategy When intracoronary imaging was used, there was a trend toward better outcomes with the dual‐stent than provisional strategy.
Recent Application and Progress of Metal Halide Perovskite Photodetector on Flexible Substrates
Authors: Li Shuigen , Xie Xiangyu , Huang Fan , Shu Lili , Liu Langyu , Wang Chasheng , Yang Yong , Li Rong
Published: July 2023

Comprehensive Summary

In recent years, flexible photodetectors (FPDs) have received increasing attention due to their applications in electronic eyes, flexible sensing, terminal devices, and wearable devices. In addition, metallic halide perovskite materials are considered as future materials for FPDs due to their compatibility with flexible substrates, low cost, simple synthesis methods, and superior optoelectronic properties. This review provides a comprehensive overview of the relevant cutting‐edge research in the field of flexible perovskite photodetectors (FPPDs) from 2020 to 2022. First, the evaluation criteria for FPPDs are discussed and the development of perovskite stability criteria is emphatically described. Afterwards, the synthesis methods and device construction processes of metal halide perovskite materials commonly used by researchers in the past three years are described. These include single crystals and low‐dimensional materials. Moreover, we have elaborated on the research of self‐powered FPPD and its contributions in wearability, terminals, and portability. Finally, a summary of developments and possibilities in the field of FPPDs from 2020 to 2022 is provided.
Handgrip strength and the prognosis of patients with heart failure: A meta‐analysis
Authors: Wang Yu , Pu Xuehua , Zhu Zhiyun , Sun Wenbin , Xue Lu , Ye Jilu
Published: July 2023

Background

Reduced muscular strength is common in patients with heart failure (HF). The aim of the systematic review and meta‐analysis was to evaluate the association between handgrip strength (HGS) and prognosis of patients with HF.

Hypothesis

Reduced HGS may be a risk factor of poor prognosis of patients with HF.

Methods

Relevant observational studies with longitudinal follow‐up were obtained by a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases. A random‐effects model was used to pool the results.

Results

Fifteen studies involving 7350 patients with HF were included in the meta‐analysis. Pooled results showed that HF patients with lower HGS were associated with a higher risk of mortality during follow‐up (risk ratio [RR]: 2.00, 95% confidence interval [CI]: 1.55–2.58, p < .001; I2 = 0%). Subgroup analysis showed that the association was not significantly affected by characteristics such as study country, design, mean age of the patients, HF status (stable or advanced/acute), HF type (reduced or preserved ejection fraction), follow‐up duration, and quality score (p for subgroup difference all > 0.05). Further analysis showed that per 1 kgf decrease of HGS was associated with an 8% increased risk of mortality during follow‐up (RR: 1.08, 95% CI: 1.05–1.11, p < .001; I2 = 12%). Moreover, HF patients with lower HGS were also related to a higher risk of composite outcome of HF rehospitalization or mortality (RR: 1.67, 95% CI: 1.19–2.35, p = .003; I2 = 53%).

Conclusion

A low HGS may be associated with poor clinical outcomes of patients with HF.
Quantifying seasonal, depression focused recharge in the context of public supply well vulnerability
Authors: Wiebe Andrew J. , Menkveld Paul G. , Rudolph David L.
Published: July 2023

Depression focused recharge (DFR) may be a hydrologically important process that impacts the vulnerability of public supply wells, specifically related to pathogenic contaminants. The nature of DFR in glacial moraine environments, such as those located in northern latitudes within North America and Europe, is less well established than in other regions such as the Prairie Pothole Region (Northern United States, Western Canada) and the High Plains Aquifer (Central United States). The objectives of this study were to quantify seasonal infiltration flux beneath a topographically‐closed depression within 50 m of a public supply well and to interpret the impact of this DFR process on well vulnerability. Field instruments including groundwater monitoring wells, pressure transducers, soil moisture sensors and temperature sensors were installed in vertical clusters to capture the dynamics of infiltration, drainage and recharge within the depression feature. Continuous weather data were recorded by a meteorological station at the site. Transient infiltration was quantified during two contrasting hydrological events. The first event (~2 days) was an intense rainfall (>50 mm) on a melting snowpack during the fall season when the soils were unfrozen. The second was a longer (35 day) period during the spring freshet when the surficial soils were initially frozen and subject to diurnal freezing and thawing and occasional precipitation events. The water table fluctuation method augmented by Darcy flux contributions, in addition to numerical modelling using the HYDRUS‐1D model, were used to quantify recharge rates beneath the depression. Numerical DFR estimates and analytical results differed by ±8%. Results indicate that recharge rates on the order of the annual regional average can occur beneath localized features in response to extreme events associated with snowmelt and intense rainfall. Such events may represent a microbial threat to groundwater quality if public supply wells are located nearby.
CXCL13 variant predicts pegylated‐interferon α treatment response in HBeAg‐positive chronic hepatitis B patients
Authors: Luo Mengqi , Zhang Lingyan , Yang Chou , Zhou Bin , Hou Jinlin , Jiang De‐Ke
Published: July 2023

As a key immune cytokine, C‐X‐C motif chemokine ligand 13 (CXCL13) has been reported to play critical roles in immune control of hepatitis B virus (HBV) infection. We aimed to screen single‐nucleotide polymorphisms (SNPs) of CXCL13 for predicting response to pegylated interferon‐alpha (PegIFNα) therapy of chronic hepatitis B (CHB) patients. Two independent cohorts with a total of 945 (Cohort 1, n = 238; Cohort 2, n = 707) hepatitis B e antigen (HBeAg)‐positive CHB patients treated with PegIFNα were enrolled in this retrospective cohort study. Eight candidate SNPs were selected through gene‐wide SNP mining within or flanking CXCL13. A polygenic score (PGS) was utilized to assess the cumulative effects of multiple SNPs. The associations of candidate SNPs and PGS with combined response (CR, defined as the combination of HBeAg seroconversion and HBV DNA level <3.3log10 IU/mL) and hepatitis B surface antigen (HBsAg) level were evaluated. Among the eight candidate SNPs, rs76084459 which is located at upstream of CXCL13 was significantly associated with both CR (p = 0.002) and HBsAg level (p = 0.015). A PGS integrating CXCL13_rs76084459 and five other SNPs, which were previously identified as predictors of PegIFNα treatment response, was further strongly correlated with CR (p = 1.759 × 10−10) and HBsAg level (p = 0.004). This study demonstrated that CXCL13_rs76084459 can predict response to PegIFNα treatment of HBeAg‐positive CHB patients. A PGS composed of six SNPs including CXCL13_rs76084459 predicts PegIFNα treatment response better.
Winter heat waves characteristics associated with downslope windstorm in south Brazil
Authors: da Rosa Cinara Ewerling , Stefanello Michel , dos Reis Nicolle Cordero Simões , Facco Douglas Stefanello , Teleginski Ferraz Simone , Boiaski Nathalie Tissot , Herdies Dirceu Luis , Degrazia Gervásio Annes
Published: July 2023

The air temperature anomaly was analysed in 16 consecutive winters from 2004 to 2019 in southern Brazil using reanalysis data and hourly atmospheric observations. In this study, 13 heat wave (HW) episodes were identified using the percentile methodology. All identified episodes are associated with the occurrence of a downslope windstorm known as Vento Norte (VNOR; Portuguese for ‘North Wind’). The VNOR is characterized by a sharp increase in air temperature combined with constant, strong, gusty winds from the north and a drop in relative humidity. The average duration was about 5 days for HW and 18 h for VNOR being than in 59.5% of the HW hours, the VNOR windstorm was also detected. The main atmospheric variables were compared during the periods of winter, HW and the VNOR windstorm. The analysis showed that HW alters local weather and climate conditions, with the more pronounced features associated with the VNOR flow. A more detailed investigation comparing the atmospheric variables collected north and south of an abrupt change in terrain altitude (400 m) revealed that the main cause of the amplification of the atmospheric variable anomalies in the centre of the state of Rio Grande do Sul was the simultaneous occurrence of HW and VNOR.
Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems
Authors: Di Luca Mariagrazia , Poursani Ensieh , Curcio Manuela , Cirillo Giuseppe , Salerno Antonietta , Bolognini Sara , De Filpo Giovanni , Filippi Sara , Vittorio Orazio , Iemma Francesca , Nicoletta Fiore Pasquale
Published: July 2023

With the objective of creating an electro‐responsive and antimicrobial device suitable as delivery system for Rose Bengal (RB) to the skin, a hybrid hydrogel combining Chitosan (CS) and Graphene Oxide (GO) are designed, serving as functional polymer support and active filling element, respectively. The hybrid system, synthesized using tripolyphosphate as a crosslinker via ionic gelation, shows a uniform and homogeneous surface, as verified by SEM investigations, high biocompatibility when tested on human fibroblast lung cells MRC‐5 cells, and biodegradability in phosphate buffered medium at physiological pH. Drug loading and release experiments, extensively analyzed using suitable mathematical modeling, shows the enhancement of the binding efficiency conferred by GO (534 and 979 mg g−1 for blank and hybrid hydrogels, respectively) and an electro‐responsive behavior (maximum BR release of 36 and 23% at 0 and 12 V, respectively). Additionally, hybrid hydrogel is found to prevent the adhesion of methicillin‐resistant Staphylococcus aureus and to kill the bacterial cells by taking advantage of the sustained release of the antimicrobial RB.
Technical note: System uncertainty on four‐ and eight‐channel parallel RF transmission for safe MRI of deep brain stimulation devices
Authors: Yang Benson , Chen Chih‐Hung , Graham Simon J.
Published: July 2023

Background

Parallel radiofrequency transmission (pTx) remains a promising technology for addressing high‐field magnetic resonance imaging (MRI) challenges, particularly regarding the safety of patients with implanted deep brain stimulation (DBS) devices. Radiofrequency (RF) shim optimization methods utilizing pTx technology have shown the potential to minimize induced RF heating effects at the electrode tips of DBS devices at 3 T.

Purpose

Research pTx system implementations often involve the combination of custom and commercial hardware that are integrated onto an existing MRI system. As a result, system characterization is important to ensure implant‐friendly safe imaging conditions are satisfied for the operating range of the hardware.

Methods

Utilizing electromagnetic and thermal simulations, the impact of system uncertainty is studied for the proposed 4‐ and 8‐channel pTx system setup and its associated “safe mode” for DBS applications.

Results

Electromagnetic simulations indicated that instrumentation errors can affect the overall electric field strength experienced at the DBS lead tip, and a worst‐case system uncertainty analysis predicted temperature elevations of +1.5°C in the 4‐channel setup and +0.9°C in the 8‐channel setup.

Conclusions

In conclusion, system uncertainty can impact the precision of pTx RF inputs which in the worst‐case, may lead to an unsafe imaging scenario and the proposed 8‐channel setup may provide more robustness and thus, safer conditions for MRI of DBS patients.