bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Affecting the Reproduction and Mass-Rearing of Sclerodermus brevicornis (Hymenoptera: Bethylidae), a Natural Enemy of Exotic Flat-Faced Longhorn Beetles (Coleoptera: Cerambycidae: Lamiinae)
Authors: Jucker Costanza , Hardy Ian C.W. , Malabusini Serena , de Milato Silvia , Zen Giacomo , Savoldelli Sara , Lupi Daniela
Published: September 2020

Many species of long-horned beetles are invasive pests causing significant economic damage in agro-forestry systems. They spend the majority of their life-cycle concealed inside natural wood or wooden packaging materials and are largely protected from adverse environmental conditions and pesticide sprays. Biological control via parasitoid natural enemies including members of the bethylid genus Sclerodermus, has proven effective against some long-horned beetles that are invasive in China. In Europe, the biocontrol potential of native Sclerodermus species is being evaluated with a view to developing efficient mass-rearing techniques and then actively deploying them against invasive Asian beetles. Here, we continue evaluations of S. brevicornis by establishing that groups of females that have already reared offspring to emergence are capable of reproducing subsequent hosts and by evaluating the lifetime reproductive capacity of individual females provided with successive hosts. Additionally, we assess the laboratory shelf-life of adult females stored for different times at different temperatures including cold storage, and then assess the post-storage reproductive performance of groups of females provided with a single host. We found that adult female longevity declines with increasing storage temperature and that most aspects of subsequent performance are negatively affected by high temperatures. The adaptability to low temperature storage enhances the suitability of S. brevicornis to mass-rearing programs and thus biocontrol deployment.
Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation
Authors: Bagoly Zsuzsa , Hajas Orsolya , Urbancsek Réka , Kiss Alexandra , Fiak Edit , Sarkady Ferenc , Tóth Noémi Klára , Orbán-Kálmándi Rita , Kovács Kitti Bernadett , Nagy László , Nagy Attila , Kappelmayer János , Csiba László , Csanádi Zoltán
Published: September 2020

Background. Cerebral thromboembolism is a rare but feared complication of transcatheter ablation in patients with atrial fibrillation (AF). Here, we aimed to test which pre-procedural anticoagulation strategy results in less intracardiac activation of hemostasis during ablation. Patients and methods. In this observational study, 54 paroxysmal/persistent AF patients undergoing cryoballoon ablation were grouped according to their periprocedural anticoagulation strategy: no anticoagulation (oral anticoagulation (OAC) free; n = 24), uninterrupted vitamin K antagonists (VKA) (n = 11), uninterrupted dabigatran (n = 17). Blood was drawn from the left atrium before and immediately after the ablation procedure. Cryoablations were performed according to standard protocols, during which heparin was administered. Heparin-insensitive markers of hemostasis and endothelial damage were tested from intracardiac samples: D-dimer, quantitative fibrin monomer (FM), plasmin-antiplasmin complex (PAP), von Willebrand factor (VWF) antigen, chromogenic factor VIII (FVIII) activity. Results. D-dimer increased significantly in all groups post-ablation, with lowest levels in the dabigatran group (median [interquartile range]: 0.27 [0.36] vs. 1.09 [1.30] and 0.74 [0.26] mg/L in OAC free and uninterrupted VKA groups, respectively, p < 0.001). PAP levels were parallel to this observation. Post-ablation FM levels were elevated in OAC free (26.34 [30.04] mg/L) and VKA groups (10.12 [16.01] mg/L), but remained below cut-off in all patients on dabigatran (3.98 [2.0] mg/L; p < 0.001). VWF antigen and FVIII activity increased similarly post-ablation in all groups, suggesting comparable procedure-related endothelial damage. Conclusion. Dabigatran provides greater inhibition against intracardiac activation of hemostasis as compared to VKAs during cryoballoon catheter ablation.
Alcohol Septal Ablation versus Septal Myectomy Treatment of Obstructive Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis
Authors: Bytyçi Ibadete , Nistri Stefano , Mörner Stellan , Henein Michael Y.
Published: September 2020

Surgical myectomy (SM) and alcohol septal ablation (ASA) are two invasive therapies for symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM), despite medical therapy. This meta-analysis aims to compare the efficacy of the two procedures. We searched all electronic databases until February 2020 for clinical trials and cohorts comparing clinical outcomes of ASA and SM treatment of patients with HOCM. The primary endpoint was all-cause mortality, cardiovascular (CV) mortality, sudden cardiac death (SCD), re-intervention, and complications. Secondary endpoints included relief of clinical symptoms and drop of left ventricular outflow tract (LVOT) gradient. Twenty studies (4547 patients; 2 CTs and 18 cohorts) comparing ASA vs. SM with a mean follow-up of 47 ± 28.7 months were included. Long term (8.72 vs. 7.84%, p = 0.42) and short term (1.12 vs. 1.27%, p = 0.93) all-cause mortality, CV mortality (2.48 vs. 3.66%, p = 0.26), SCD (1.78 vs. 0.76%, p = 0.20) and stroke (0.36 vs. 1.01%, p = 0.64) were not different between procedures. ASA was associated with lower peri-procedural complications (5.57 vs. 10.5%, p = 0.04) but higher rate of re-interventions (10.1 vs. 0.27%; p < 0.001) and pacemaker dependency (12.4 vs. 4.31%, p = 0.0004) compared to SM. ASA resulted in less reduction in LVOT gradient (−47.8 vs. −58.4 mmHg, p = 0.01) and less improvement of clinical symptoms compared to SM (New York Heart Association (NYHA) class III/IV, 82.4 vs. 94.5%, p < 0.001, angina 53.2 vs. 84.2%, p = 0.02). Thus, ASA and SM treatment of HOCM carry a similar risk of mortality. Peri-procedural complications are less in alcohol ablation but re-intervention and pacemaker implantations are more common. These results might impact the procedure choice in individual patients, for the best clinical outcome.
A New Therapeutic Application of Platelet-Rich Plasma to Chronic Breast Wounds: A Prospective Observational Study
Authors: Berná-Serna Juan de Dios , Guzmán-Aroca Florentina , García-Vidal José A. , Hernández-Gómez Dolores , García-Ortega Ana Azahara , Chivato Martín-Falquina Tomás , Piñero-Madrona Antonio , Berná-Mestre Juan de Dios
Published: September 2020

The aim of this study was to investigate the usefulness of platelet-rich plasma (PRP) treatment for chronic wounds (CWs) of the breast. A prospective study was performed in 23 patients with CW of the breast who were treated with PRP. The procedure was repeated until the wound was closed completely. The study included patients with a history of breast cancer (n = 8) and patients without cancer (n = 15). The treatment with PRP was successful in all cases and observed in ≤4 weeks in 82.6% (19/23) of patients. The patients without breast cancer showed significantly less time for wound closure than the patients with a history of breast cancer. Moreover, a greater number of PRP treatments were necessary to achieve wound closure in patients undergoing conservative breast treatment. No patients had complications associated with the application of PRP. Conclusions: To the best of our knowledge, this is the first study to reveal that PRP treatment for CWs of the breast is safe, simple, useful and well-tolerated by patients.
Negative Effect of Reduced NME1 Expression on Recurrence-Free Survival in Early Stage Non-Small Cell Lung Cancer
Authors: Kim Dohun , Kim Yujin , Lee Bo Bin , Kim Dongho , Lee Ok-Jun , Jeong Pildu , Kim Wun-Jae , Cho Eun Yoon , Han Joungho , Shim Young Mog , Kim Duk-Hwan
Published: September 2020

This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β-catenin were analyzed using immunohistochemistry in formalin-fixed paraffin-embedded tissues from 425 early stage NSCLC patients. Reduced NME1 expression was found in 39% of samples. The median duration of follow-up was 56 months, and recurrence was found in 186 (44%) of 425 patients. The negative effect of reduced NME1 expression on RFS was worsened by cisplatin-based adjuvant chemotherapy (adjusted hazard ratio = 3.26, 95% CI = 1.16–9.17, p = 0.03). β-catenin overexpression exacerbated the effect of reduced NME1 expression on RFS and the negative effect was greater when receiving cisplatin-based adjuvant chemotherapy: among patients treated with cisplatin-based adjuvant chemotherapy, hazard ratios of patients with reduced NME1 expression increased from 5.59 (95% confidence interval (CI) = 0.62–50.91, p = 0.13) to 15.52 (95% CI = 2.94–82.38, p = 0.001) by β-catenin overexpression, after adjusting for confounding factors. In conclusion, the present study suggests that cisplatin-based adjuvant chemotherapy needs to be carefully applied to early stage NSCLC patients with overexpressed β-catenin in combination with reduced NME1 expression.
Effects of Initial Periodontal Therapy on Heat Shock Protein 70 Levels in Gingival Crevicular Fluid from Periodontitis Patients
Authors: Furuse Nobuhisa , Takai Hideki , Ogata Yorimasa
Published: September 2020

Periodontitis is an inflammatory disease of periodontium which is caused by periodontopathic bacteria. Moreover, various cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and IL-6 are expressed in the inflamed periodontium. Heat shock proteins (HSPs) protect cells from abnormal conditions including inflammation, microbial infection and diseases. The 70-kDa HSPs (HSP70s) are major HSPs that express in the inflamed tissues. In this study, an enzyme-linked immunosorbent assay was applied to measure the levels of HSP70 in gingival crevicular fluid (GCF) from two periodontal pockets in each of 10 patients with Stage III, Grade B periodontitis. Sites with probing pocket depth (PPD) of ≤3 mm were named the healthy control (HC) sites, and sites with PPD of ≥5 mm were named the diseased sites. HSP70 levels in GCF were expressed higher at diseased sites than at HC sites, and decreased after initial periodontal therapy at diseased sites. These results suggest the association of HSP70 with the stage of periodontitis.
Ganglionated Plexi Ablation for the Treatment of Atrial Fibrillation
Authors: Avazzadeh Sahar , McBride Shauna , O’Brien Barry , Coffey Ken , Elahi Adnan , O’Halloran Martin , Soo Alan , Quinlan Leo. R
Published: September 2020

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system (ANS) plays an important role in the initiation and development of AF, causing alterations in atrial structure and electrophysiological defects. The intrinsic ANS of the heart consists of multiple ganglionated plexi (GP), commonly nestled in epicardial fat pads. These GPs contain both parasympathetic and sympathetic afferent and efferent neuronal circuits that control the electrophysiological properties of the myocardium. Pulmonary vein isolation and other cardiac catheter ablation targets including GP ablation can disrupt the fibers connecting GPs or directly damage the GPs, mediating the benefits of the ablation procedure. Ablation of GPs has been evaluated over the past decade as an adjunctive procedure for the treatment of patients suffering from AF. The success rate of GP ablation is strongly associated with specific ablation sites, surgical techniques, localization techniques, method of access and the incorporation of additional interventions. In this review, we present the current data on the clinical utility of GP ablation and its significance in AF elimination and the restoration of normal sinus rhythm in humans.
Global and Local Modeling of Land Use Change in the Border Cities of Laredo, Texas, USA and Nuevo Laredo, Tamaulipas, Mexico: A Comparative Analysis
Authors: Zhao Chunhong , Jensen Jennifer L.R. , Weaver Russell
Published: September 2020

This paper estimates global logistic regression and logistic geographically weighted regression (GWR) models of urban growth in the adjacent border cities of Laredo, Texas in the United States and Nuevo Laredo, Tamaulipas in Mexico, for two time periods from 1985 to 2014. Historical land use and land cover patterns were monitored through Landsat imagery from the United States Geological Survey to identify instances of urban growth through land type change. Data on socioeconomic variables related to urban growth were collected from various sources and used as independent variables. In both time periods, the logistic GWR was proven to be a complementary model for the global logistic regression to explore the urban growth effect. In addition, GWR outperformed the global logistic regression model with respect to goodness of fit. These results suggest that local models are complementary to global models to empirically analyze the determinants of urban growth in study areas that contain political borders, presumably because the relationships between socioeconomic factors and urban growth are characterized by spatial heterogeneity in such areas. The spatial variable of the relationship between urban growth and the neighborhood interactions and proximity effect present the idea of complexity and interconnections between the land use change and associated factors.
Hot Deformation Behavior and Microstructure Evolution of 6063 Aluminum Alloy Modified by Rare Earth Y and Al-Ti-B Master Alloy
Authors: Ding Wanwu , Liu Xiaoxiong , Zhao Xiaoyan , Chen Taili , Zhang Haixia , Cheng Yan , Shi Huaixin
Published: September 2020

The hot deformation behaviors of the new 6063 aluminum alloy modified by rare earth Y and Al-Ti-B master alloy were studied through isothermal hot compression experiments on the Gleeble-3800 thermal simulator. By characterizing the flow curves, constitutive models, hot processing maps, and microstructures, we can see from the true stress–true strain curves that the flow stress decreases with the increase of deformation temperature and the decrease of strain rate. Through the calculation of the constitutive equation, we derived that the activation energy of the new composite modified 6063 aluminum alloy is 224.570 KJ/mol. we roughly obtained its excellent hot processing range of temperatures between 470–540 °C and the strain rates of 0.01–0.1 s−1. The verification of the deformed microstructure shows that with the decrease of lnZ, the grain boundary changes from a low-angle one to a high-angle one and the dynamic recrystallization is dominated by geometric dynamic recrystallization and continuous dynamic recrystallization. Analysis of typical samples at 480 °C/0.01 s−1 shows that the addition of rare earth Y mainly helps form Al3Y5 and AlFeSiY phases, thus making the alloy have the performance of high-temperature recrystallization, which is beneficial to the hot workability of the alloy.
Effects of Portland Cement and Polymer Powder on the Properties of Cement-Bound Road Base Mixtures
Authors: Buczyński Przemysław , Iwański Marek , Mazurek Grzegorz , Krasowski Jakub , Krasowski Maciej
Published: September 2020

This article presents the test results for the physical and mechanical properties and fracture toughness of polymer-modified hydraulically-bound mixtures (HBM) produced with Portland cement for road base layers. The modifier used was a redispersible polymer powder (RPP) based on a vinyl ethylene acetate (EVA) copolymer obtained by spray drying. A three-level full factorial design with two factors was applied to determine the contents of Portland cement and polymer powder in the cement-bound mixture (CBM). Both Portland cement and polymer powder were added at three levels: 0%, 2%, and 4%. The assessment included basic physical properties (water absorption, density, and bulk density) and mechanical properties (stiffness modulus, axial compressive strength, and indirect tensile strength) of the CBM. Particular attention was paid to the assessment of fracture toughness in the semi-circular bending test. The results of the research show that polymer powder positively influenced the mechanical properties of CBM by improving its cohesion while maintaining its stiffness. Another benefit coming from the use of polymer powder was the CBM’s increased resistance to cracking, which is the desired characteristic from the perspective of pavement durability.
Strengthening of a Near β-Ti Alloy through β Grain Refinement and Stress-Induced α Precipitation
Authors: Chen Wei , Li Chao , Feng Kangtun , Lin Yongcheng , Zhang Xiaoyong , Chen Chao , Zhou Kechao
Published: September 2020

Near β-Ti alloys with high strength and good ductility are desirable for application in aviation and aerospace industries. Nevertheless, strength and ductility are usually mutually exclusive in structural materials. Here we report a new thermo-mechanical process, that is, the alloy was cross-rolled in β field then aged at 600 °C for 1 h. By such a process, a high strength (ultimate tensile strength: 1480 MPa) and acceptable ductility (elongation: 10%) can be simultaneously achieved in the near β-Ti alloy, based on the microscale β matrix and nanoscale α phase. The microstructure evolution, mechanical properties and strengthening mechanisms have been clarified by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results showed that the grain size of the β phase progressively decreased with the increasing of rolling reduction. Moreover, dense dislocation structures and martensite phases distributed in the cross-rolled β matrix can effectively promote the precipitation of nanoscale α particles. TEM analyses confirmed that a heat-treatment twin was generated in the newly formed α lath during aging. These findings provide insights towards developing Ti alloys with optimized mechanical properties.
Coefficient Estimates for a Subclass of Starlike Functions
Authors: Răducanu Dorina
Published: September 2020

In this note, we consider a subclass H3/2(p) of starlike functions f with f″(0)=p for a prescribed p∈[0,2]. Usually, in the study of univalent functions, estimates on the Taylor coefficients, Fekete–Szegö functional or Hankel determinats are given. Another coefficient problem which has attracted considerable attention is to estimate the moduli of successive coefficients |an+1|−|an|. Recently, the related functional |an+1−an| for the initial successive coefficients has been investigated for several classes of univalent functions. We continue this study and for functions f(z)=z+∑n=2∞anzn∈H3/2(p), we investigate upper bounds of initial coefficients and the difference of moduli of successive coefficients |a3−a2| and |a4−a3|. Estimates of the functionals |a2a4−a32| and |a4−a2a3| are also derived. The obtained results expand the scope of the theoretical results related with the functional |an+1−an| for various subclasses of univalent functions.
Certain Properties of Vague Graphs with a Novel Application
Authors: Rao Yongsheng , Kosari Saeed , Shao Zehui
Published: September 2020

Fuzzy graph models enjoy the ubiquity of being present in nature and man-made structures, such as the dynamic processes in physical, biological, and social systems. As a result of inconsistent and indeterminate information inherent in real-life problems that are often uncertain, for an expert, it is highly difficult to demonstrate those problems through a fuzzy graph. Resolving the uncertainty associated with the inconsistent and indeterminate information of any real-world problem can be done using a vague graph (VG), with which the fuzzy graphs may not generate satisfactory results. The limitations of past definitions in fuzzy graphs have led us to present new definitions in VGs. The objective of this paper is to present certain types of vague graphs (VGs), including strongly irregular (SI), strongly totally irregular (STI), neighborly edge irregular (NEI), and neighborly edge totally irregular vague graphs (NETIVGs), which are introduced for the first time here. Some remarkable properties associated with these new VGs were investigated, and necessary and sufficient conditions under which strongly irregular vague graphs (SIVGs) and highly irregular vague graphs (HIVGs) are equivalent were obtained. The relation among strongly, highly, and neighborly irregular vague graphs was established. A comparative study between NEI and NETIVGs was performed. Different examples are provided to evaluate the validity of the new definitions. A new definition of energy called the Laplacian energy (LE) is presented, and its calculation is shown with some examples. Likewise, we introduce the notions of the adjacency matrix (AM), degree matrix (DM), and Laplacian matrix (LM) of VGs. The lower and upper bounds for the Laplacian energy of a VG are derived. Furthermore, this study discusses the VG energy concept by providing a real-time example. Finally, an application of the proposed concepts is presented to find the most effective person in a hospital.
A New Family of Discrete Distributions with Mathematical Properties, Characterizations, Bayesian and Non-Bayesian Estimation Methods
Authors: Aboraya Mohamed , M. Yousof Haitham , Hamedani G.G. , Ibrahim Mohamed
Published: September 2020

In this work, we propose and study a new family of discrete distributions. Many useful mathematical properties, such as ordinary moments, moment generating function, cumulant generating function, probability generating function, central moment, and dispersion index are derived. Some special discrete versions are presented. A certain special case is discussed graphically and numerically. The hazard rate function of the new class can be “decreasing”, “upside down”, “increasing”, and “decreasing-constant-increasing (U-shape)”. Some useful characterization results based on the conditional expectation of certain function of the random variable and in terms of the hazard function are derived and presented. Bayesian and non-Bayesian methods of estimation are considered. The Bayesian estimation procedure under the squared error loss function is discussed. Markov chain Monte Carlo simulation studies for comparing non-Bayesian and Bayesian estimations are performed using the Gibbs sampler and Metropolis–Hastings algorithm. Four applications to real data sets are employed for comparing the Bayesian and non-Bayesian methods. The importance and flexibility of the new discrete class is illustrated by means of four real data applications.
Unsteady Stagnation Point Flow of Hybrid Nanofluid Past a Convectively Heated Stretching/Shrinking Sheet with Velocity Slip
Authors: Zainal Nurul Amira , Nazar Roslinda , Naganthran Kohilavani , Pop Ioan
Published: September 2020

Unsteady stagnation point flow in hybrid nanofluid (Al2O3-Cu/H2O) past a convectively heated stretching/shrinking sheet is examined. Apart from the conventional surface of the no-slip condition, the velocity slip condition is considered in this study. By incorporating verified similarity transformations, the differential equations together with their partial derivatives are changed into ordinary differential equations. Throughout the MATLAB operating system, the simplified mathematical model is clarified by employing the bvp4c procedure. The above-proposed approach is capable of producing non-uniqueness solutions when adequate initial assumptions are provided. The findings revealed that the skin friction coefficient intensifies in conjunction with the local Nusselt number by adding up the nanoparticles volume fraction. The occurrence of velocity slip at the boundary reduces the coefficient of skin friction; however, an upward trend is exemplified in the rate of heat transfer. The results also signified that, unlike the parameter of velocity slip, the increment in the unsteady parameter conclusively increases the coefficient of skin friction, and an upsurge attribution in the heat transfer rate is observed resulting from the increment of Biot number. The findings are evidenced to have dual solutions, which inevitably contribute to stability analysis, hence validating the feasibility of the first solution.
Opposition-Based Ant Colony Optimization Algorithm for the Traveling Salesman Problem
Authors: Zhang Zhaojun , Xu Zhaoxiong , Luan Shengyang , Li Xuanyu , Sun Yifei
Published: September 2020

Opposition-based learning (OBL) has been widely used to improve many swarm intelligent optimization (SI) algorithms for continuous problems during the past few decades. When the SI optimization algorithms apply OBL to solve discrete problems, the construction and utilization of the opposite solution is the key issue. Ant colony optimization (ACO) generally used to solve combinatorial optimization problems is a kind of classical SI optimization algorithm. Opposition-based ACO which is combined in OBL is proposed to solve the symmetric traveling salesman problem (TSP) in this paper. Two strategies for constructing opposite path by OBL based on solution characteristics of TSP are also proposed. Then, in order to use information of opposite path to improve the performance of ACO, three different strategies, direction, indirection, and random methods, mentioned for pheromone update rules are discussed individually. According to the construction of the inverse solution and the way of using it in pheromone updating, three kinds of improved ant colony algorithms are proposed. To verify the feasibility and effectiveness of strategies, two kinds of ACO algorithms are employed to solve TSP instances. The results demonstrate that the performance of opposition-based ACO is better than that of ACO without OBL.
Current Evidence Regarding Biomarkers Used to Aid Postoperative Delirium Diagnosis in the Field of Cardiac Surgery—Review
Authors: Majewski Paweł , Zegan-Barańska Małgorzata , Karolak Igor , Kaim Karolina , Żukowski Maciej , Kotfis Katarzyna
Published: September 2020

Postoperative cognitive disorders after cardiac surgery may manifest as postoperative delirium (POD) or later as postoperative cognitive dysfunction (POCD). The incidence of POD after cardiac surgery ranges from 16% to 73%. In contrast to POD, POCD is usually diagnosed after the discharge from hospital, with an incidence of 30 to 70% of cases, very often noticed only by close relative or friends, decreasing after six (20–30%) and twelve (15–25%) months after surgery. Perioperative cognitive disorders are associated with adverse short- and long-term effects, including increased morbidity and mortality. Due to the complexity of delirium pathomechanisms and the difficulties in the diagnosis, researchers have not yet found a clear answer to the question of which patient will be at a higher risk of developing delirium. The risk for POD and POCD in older patients with numerous comorbidities like hypertension, diabetes, and previous ischemic stroke is relatively high, and the predisposing cognitive profile for both conditions is important. The aim of this narrative review was to identify and describe biomarkers used in the diagnosis of delirium after cardiac surgery by presenting a search through studies regarding this subject, which have been published during the last ten years. The authors discussed brain-derived biomarkers, inflammation-related biomarkers, neurotransmitter-based biomarkers, and others. Work based on inflammation-related biomarkers, which are characterized by the low cost of implementation and the effectiveness of delirium diagnosis, seems to be the closest to the goal of discovering an inexpensive and effective marker. Currently, the use of a panel of tests, and not a single biomarker, brings us closer to the discovery of a test, or rather a set of tests ideal for the diagnosis of delirium after cardiac surgery.
Structural Analysis of Brain Hub Region Volume and Cortical Thickness in Patients with Mild Cognitive Impairment and Dementia
Authors: Zdanovskis Nauris , Platkājis Ardis , Kostiks Andrejs , Karelis Guntis
Published: September 2020

Background and Objectives: A complex network of axonal pathways interlinks the human brain cortex. Brain networks are not distributed evenly, and brain regions making more connections with other parts are defined as brain hubs. Our objective was to analyze brain hub region volume and cortical thickness and determine the association with cognitive assessment scores in patients with mild cognitive impairment (MCI) and dementia. Materials and Methods: In this cross-sectional study, we included 11 patients (5 mild cognitive impairment; 6 dementia). All patients underwent neurological examination, and Montreal Cognitive Assessment (MoCA) test scores were recorded. Scans with a 3T MRI scanner were done, and cortical thickness and volumetric data were acquired using Freesurfer 7.1.0 software. Results: By analyzing differences between the MCI and dementia groups, MCI patients had higher hippocampal volumes (p < 0.05) and left entorhinal cortex thickness (p < 0.05). There was a significant positive correlation between MoCA test scores and left hippocampus volume (r = 0.767, p < 0.01), right hippocampus volume (r = 0.785, p < 0.01), right precuneus cortical thickness (r = 0.648, p < 0.05), left entorhinal cortex thickness (r = 0.767, p < 0.01), and right entorhinal cortex thickness (r = 0.612, p < 0.05). Conclusions: In our study, hippocampal volume and entorhinal cortex showed significant differences in the MCI and dementia patient groups. Additionally, we found a statistically significant positive correlation between MoCA scores, hippocampal volume, entorhinal cortex thickness, and right precuneus. Although other brain hub regions did not show statistically significant differences, there should be additional research to evaluate the brain hub region association with MCI and dementia.
Prediction of the Ideal Implant Size Using 3-Dimensional Healthy Breast Volume in Unilateral Direct-to-Implant Breast Reconstruction
Authors: Kim Jeong-Hoon , Park Jin-Woo , Woo Kyong-Je
Published: September 2020

Background and objectives: There is no consensus regarding accurate methods for assessing the size of the implant required for achieving symmetry in direct-to-implant (DTI) breast reconstruction. The purpose of this study was to determine whether the ideal implant size could be estimated using 3D breast volume or mastectomy specimen weight, and to compare prediction performances between the two variables. Materials and Methods: Patients who underwent immediate DTI breast reconstruction from August 2017 to April 2020 were included in this study. Breast volumes were measured using 3D surface imaging preoperatively and at postoperative three months. Ideal implant size was calculated by correcting the used implant volume by the observed postoperative asymmetry in 3D surface imaging. Prediction models using mastectomy weight or 3D volume were made to predict the ideal implant volume. The prediction performance was compared between the models. Results: A total of 56 patients were included in the analysis. In correlation analysis, the volume of the implant used was significantly correlated with the mastectomy specimen weight (R2 = 0.810) and the healthy breast volume (R2 = 0.880). The mean ideal implant volume was 278 ± 123 cc. The prediction model was developed using the healthy breast volume: Implant volume (cc) = healthy breast volume × 0.78 + 26 cc (R2 = 0.900). The prediction model for the ideal implant size using the 3D volume showed better prediction performance than that of using the mastectomy specimen weight (R2 = 0.900 vs 0.759, p < 0.001). Conclusions: The 3D volume of the healthy breast is a more reliable predictor than mastectomy specimen weight to estimate the ideal implant size. The estimation formula obtained in this study may assist in the selection of the ideal implant size in unilateral DTI breast reconstruction.
Impact of ED Organization with a Holding Area and a Dedicated Team on the Adherence to International Guidelines for Patients with Acute Pulmonary Embolism: Experience of an Emergency Department Organized in Areas of Intensity of Care
Authors: Savioli Gabriele , Ceresa Iride Francesca , Maggioni Paolo , Lava Massimiliano , Ricevuti Giovanni , Manzoni Federica , Oddone Enrico , Bressan Maria Antonietta
Published: September 2020

Background: Adherence to guidelines by physicians of an emergency department (ED) depends on many factors: guideline and environmental factors; patient and practitioner characteristics; the social-political context. We focused on the impact of the environmental influence and of the patients’ characteristics on adherence to the guidelines. It is our intention to demonstrate how environmental factors such as ED organization more affect adherence to guidelines than the patient’s clinical presentation, even in a clinically insidious disease such as pulmonary embolism (PE). Methods: A single-center observational study was carried out on all patients who were seen at our Department of Emergency and Acceptance from 1 January to 31 December 2017 for PE. For the assessment of adherence to guidelines, we used the European guidelines 2014 and analyzed adherence to the correct use of clinical decision rule (CDR as Wells, Geneva, and YEARS); the correct initiation of heparin therapy; and the management of patients at high risk for short-term mortality. The primary endpoint of our study was to determine whether adherence to the guidelines as a whole depends on patients’ management in a holding area. The secondary objective was to determine whether adherence to the guidelines depended on patient characteristics such as the presence of typical symptoms or severe clinical features (massive pulmonary embolism; organ damage). Results: There were significant differences between patients who passed through OBI and those who did not, in terms of both administration of heparin therapy alone (p = 0.007) and the composite endpoints of heparin therapy initiation and observation/monitoring (p = 0.004), as indicated by the guidelines. For the subgroups of patients with massive PE, organ damage, and typical symptoms, there was no greater adherence to the decision making, administration of heparin therapy alone, and the endpoints of heparin therapy initiation and guideline-based observation/monitoring. Conclusions: Patients managed in an ED holding area were managed more in accordance with the guidelines than those who were managed only in the visiting ED rooms and directly hospitalized from there.
Advances in Label-Free Detections for Nanofluidic Analytical Devices
Authors: Le Thu , Shimizu Hisashi , Morikawa Kyojiro
Published: September 2020

Nanofluidics, a discipline of science and engineering of fluids confined to structures at the 1–1000 nm scale, has experienced significant growth over the past decade. Nanofluidics have offered fascinating platforms for chemical and biological analyses by exploiting the unique characteristics of liquids and molecules confined in nanospaces; however, the difficulty to detect molecules in extremely small spaces hampers the practical applications of nanofluidic devices. Laser-induced fluorescence microscopy with single-molecule sensitivity has been so far a major detection method in nanofluidics, but issues arising from labeling and photobleaching limit its application. Recently, numerous label-free detection methods have been developed to identify and determine the number of molecules, as well as provide chemical, conformational, and kinetic information of molecules. This review focuses on label-free detection techniques designed for nanofluidics; these techniques are divided into two groups: optical and electrical/electrochemical detection methods. In this review, we discuss on the developed nanofluidic device architectures, elucidate the mechanisms by which the utilization of nanofluidics in manipulating molecules and controlling light–matter interactions enhances the capabilities of biological and chemical analyses, and highlight new research directions in the field of detections in nanofluidics.
Circuit Simulation Considering Electrical Coupling in Monolithic 3D Logics with Junctionless FETs
Authors: Ahn Tae Jun , Yu Yun Seop
Published: September 2020

The junctionless field-effect transistor (JLFET) compact model using the model parameters extracted from the LETI-UTSOI (version 2.1) model was proposed to perform circuit simulation considering the electrical coupling between the stacked JLFETs of a monolithic 3D integrated circuit (M3DIC) composed of JLFETs (M3DIC-JLFET). We validated the model by extracting the model parameters and comparing the simulation results of the technology computer-aided design and the Synopsys HSPICE circuit simulator. The performance of the M3DIC-JLFET was compared with that of the M3DIC composed of MOSFETs (M3DIC-MOSFET). The performance of a fan-out-3 ring oscillator with M3DIC-JLFET varied by less than 3% compared to that with M3DIC-MOSFET. The performances of ring oscillators of M3DIC-JLFET and M3DIC-MOSFET were almost the same. We simulated the performances of M3DICs such as an inverter, a NAND, a NOR, a 2 × 1 multiplexer, and a D flip-flop. The overall performance of the M3DIC-MOSFET was slightly better than that of the M3DIC-JLFET.
Special Issue: “Actinobacteria and Myxobacteria—Important Resources for Novel Antibiotics”
Authors: Wink Joachim
Published: September 2020

The history of our antibiotics is inseparably connected to microorganisms as producers [...]
An Unexpectedly Broad Thermal and Salinity-Tolerant Estuarine Methanogen Community
Authors: Blake Lynsay I. , Sherry Angela , Mejeha Obioma K. , Leary Peter , Coombs Henry , Stone Wendy , Head Ian M. , Gray Neil D.
Published: September 2020

Moderately thermophilic (Tmax, ~55 °C) methanogens are identified after extended enrichments from temperate, tropical and low-temperature environments. However, thermophilic methanogens with higher growth temperatures (Topt ≥ 60 °C) are only reported from high-temperature environments. A microcosm-based approach was used to measure the rate of methane production and methanogen community structure over a range of temperatures and salinities in sediment from a temperate estuary. We report short-term incubations (<48 h) revealing methanogens with optimal activity reaching 70 °C in a temperate estuary sediment (in situ temperature 4–5 °C). While 30 °C enrichments amended with acetate, H2 or methanol selected for corresponding mesophilic trophic groups, at 60 °C, only hydrogenotrophs (genus Methanothermobacter) were observed. Since these methanogens are not known to be active under in situ temperatures, we conclude constant dispersal from high temperature habitats. The likely provenance of the thermophilic methanogens was studied by enrichments covering a range of temperatures and salinities. These enrichments indicated that the estuarine sediment hosted methanogens encompassing the global activity envelope of most cultured species. We suggest that estuaries are fascinating sink and source environments for microbial function study.
Effect of Fast-Growing Trees on Soil Properties and Carbon Storage in an Afforested Coal Mine Land (India)
Authors: Ahirwal Jitendra , Kumar Adarsh , Maiti Subodh Kumar
Published: September 2020

Surface coal mining activities have numerous consequences on terrestrial ecosystems. Loss of soil and biomass carbon pool due to mining activities is a serious concern in the rapidly changing environment. We investigated the effect of fast-growing trees (Albizia lebbeck, Albizia procera, and Dalbergia sissoo) on soil fertility and ecosystem carbon pool after eight years of afforestation in the post-mining land of Jharia coalfield, India, and compared with the adjacent natural forest site. Significant differences in soil organic carbon (SOC) and total nitrogen (TN) stocks in afforested mine soil and natural forest soils were observed. Greater SOC stock was found under D. sissoo (30.17 Mg·C·ha−1) while total N stock was highest under A. lebbeck (4.16 Mg·N·ha−1) plantation. Plant biomass accumulated 85% of the natural forest carbon pool after eight years of afforestation. The study concluded that planting fast-growing trees in post-mining lands could produce a promising effect on mine soil fertility and greater carbon storage in a short period.
Does Incorporating Gender Differences into Quantifying a Food Frequency Questionnaire Influence the Association of Total Energy Intake with All-Cause and Cause-Specific Mortality?
Authors: Kang Minji , Park Song-Yi , Boushey Carol J. , Wilkens Lynne R. , Le Marchand Loïc , Hankin Jean H. , Paik Hee-Young
Published: September 2020

This study aims to evaluate whether incorporating gender differences in portion sizes as part of quantifying a food frequency questionnaire influences the association of total energy intake with mortality. The analysis included 156,434 participants (70,142 men and 86,292 women) in the Multiethnic Cohort Study, aged 45–75 years at baseline. A total of 49,728 deaths were identified during an average follow-up of 18.1 years. Total energy intake and percentage energy from macronutrients were calculated using original portion sizes (PSs) and gender specific (GS)-PS and were divided into quintiles for men and women. The associations of total energy intake and percentage energy from macronutrients with all-cause, cardiovascular disease (CVD), and cancer mortality were examined using Cox regression with adjustment for potential confounders. Mean ± standard deviation daily total energy intake using original-PS was 2449 ± 1135 kcal for men and 1979 ± 962 kcal for women; using GS-PS was 1996 ± 884 kcal for men and 1595 ± 731 kcal for women. For men, the hazard ratios (HRs) (95% confidence intervals) for all-cause, CVD, and cancer comparing the highest to the lowest quintile of total energy intake were 1.05 (1.00–1.10), 1.07 (0.99–1.16), 1.03 (0.95–1.13) using original-PS and 1.07 (1.02–1.12), 1.11 (1.03–1.20), 1.02 (0.94–1.12) using GS-PS, respectively. For women, the corresponding HRs were 1.03 (0.98–1.09), 0.99 (0.91–1.08), 1.10 (1.00–1.21) using original-PS and 1.06 (1.01–1.12), 1.02 (0.94–1.12), 1.07 (0.97–1.18) using GS-PS. Both versions of percentage energy from total fat were associated with an increased risk of all-cause, CVD, and cancer mortality; on the other hand, both versions of percentage energy from carbohydrate showed inverse associations with all-cause, CVD, and cancer mortality in both men and women. When using original-PS and GS-PS, the estimated total energy intake differed, resulting in marginal differences in the associations of total energy intake with all-cause, CVD, and cancer mortality.
Enteral Bioactive Factor Supplementation in Preterm Infants: A Systematic Review
Authors: Mank Elise , Naninck Eva F. G. , Limpens Jacqueline , van Toledo Letty , van Goudoever Johannes B. , van den Akker Chris H. P.
Published: September 2020

Feeding preterm infants with mother’s own milk is associated with a reduction in postnatal complications and an improved neurocognitive outcome. Therefore, the bioactive factor composition of human milk has been used as a tool for the development of nutritional supplements with a potential prophylactic or therapeutic effect. The aim of this systematic review was to provide an overview on bioactive factors which have been studied as supplement to enteral nutrition in randomized controlled trials, and to provide an overview of ongoing trials. MEDLINE, EMBASE, CENTRAL, and clinical trial registers were searched. Studies on the antimicrobial protein lactoferrin were excluded as these were summarized very recently in three separate systematic reviews. Studies on vitamins D, K and iron were also excluded as they are already incorporated in most international guidelines. We identified 17 different bioactive factors, which were investigated in 26 studies. Despite the encouraging potential effects of several bioactive factors, more high-quality studies with a sufficient number of preterm infants are required before a certain factor may be implemented into clinical practice. Three large trials (n > 500) that investigate the effects of either enteral insulin or vitamin A are currently ongoing and could provide more definite answers on these specific supplements.
Families’ Perception of Classic Ketogenic Diet Management in Acute Medical Conditions: A Web-Based Survey
Authors: Pasca Ludovica , Varesio Costanza , Ferraris Cinzia , Guglielmetti Monica , Trentani Claudia , Tagliabue Anna , Veggiotti Pierangelo , De Giorgis Valentina
Published: September 2020

Objective: To describe families’ experiences in managing epileptic patients undergoing ketogenic dietary therapies (KDTs) in acute medical settings. Methods: We conducted a short online survey addressed to the families of patients undergoing a classic ketogenic diet (cKD) for at least three months. The survey was composed of 18 questions exploring the following issues: demographic characteristics, epilepsy diagnosis, ketogenic-diet treatment history, the reason for emergency-ward admission and patient management, surgery-procedure management, and outcomes. Results: A sample of 50 families agreed to participate. Out of 50 patients, 33 (66%) had been undergoing a cKD for more than two years. Fifteen (30%) patients had been admitted at least once to the Emergency Room (ER), and 8.2% had undergone surgical procedures during cKD treatment. The causes of ER admission were the following: seizures, infection, trauma, and gastrointestinal or respiratory problems. In 75% of cases, blood ketonemia was not monitored during ER admission, and according to 46% of responders, the medical staff intervening did not have a basic knowledge of KDTs. Conclusions: According to both our experience and caregivers’ reports, it might be useful to search for standardized specific approaches to patients undergoing KDTs in the emergency setting.
A Priori and a Posteriori Dietary Patterns in Women of Childbearing Age in the UK
Authors: Khaled Karim , Hundley Vanora , Almilaji Orouba , Koeppen Mareike , Tsofliou Fotini
Published: September 2020

Poor diet quality is a major cause of maternal obesity. We aimed to investigate a priori and a-posteriori derived dietary patterns in childbearing-aged women in UK. An online survey assessed food intake, physical activity (PA), anthropometry and socio-demographics. An a priori defined diet quality was determined via Mediterranean diet (MD) adherence score and Exploratory Factor Analysis (EFA) derived dietary patterns (DPs). Multiple linear regression explored associations between DPs with anthropometric measures, PA and socio-demographics. Participants (n = 123) had low-to-medium MD adherence (average MD-score: 4.0 (2.0)). Age was positively associated with higher MD adherence (X2 (2) = 13.14, p = 0.01). EFA revealed three DPs: ‘fruits, nuts, vegetables and legumes’ (“Vegetarian-style” DP); ‘sweets, cereals, dairy products and potatoes’ (“Dairy, sweets and starchy foods” DP); and ‘eggs, seafood and meats’ (“Protein-rich” DP). “Vegetarian-style” DP was positively associated with higher maternal educational level (p < 0.01) and PA (p = 0.01), but negatively with white ethnicity (p < 0.01). “Dairy, sweets and starchy foods” DP was positively associated with white ethnicity (p = 0.03) and negatively with age (p = 0.03). “Protein-rich” DP was positively associated with age (p < 0.001) and negatively with PA (p = 0.01). A poor diet quality was found among childbearing-aged women; notably in the younger age category, those of white ethnicity, that were more physically inactive and with a lower socioeconomic background.