bluuebunny/crossref_metadata_2025 huggingface dataset:
Taxonomic distribution and origins of the extended LHC (light-harvesting complex) antenna protein superfamily
Authors: Engelken Johannes , Brinkmann Henner , Adamska Iwona
Published: March 2019

Background

The extended light-harvesting complex (LHC) protein superfamily is a centerpiece of eukaryotic photosynthesis, comprising the LHC family and several families involved in photoprotection, like the LHC-like and the photosystem II subunit S (PSBS). The evolution of this complex superfamily has long remained elusive, partially due to previously missing families.

Results

In this study we present a meticulous search for LHC-like sequences in public genome and expressed sequence tag databases covering twelve representative photosynthetic eukaryotes from the three primary lineages of plants (Plantae): glaucophytes, red algae and green plants (Viridiplantae). By introducing a coherent classification of the different protein families based on both, hidden Markov model analyses and structural predictions, numerous new LHC-like sequences were identified and several new families were described, including the red lineage chlorophyll a/b-binding-like protein (RedCAP) family from red algae and diatoms. The test of alternative topologies of sequences of the highly conserved chlorophyll-binding core structure of LHC and PSBS proteins significantly supports the independent origins of LHC and PSBS families via two unrelated internal gene duplication events. This result was confirmed by the application of cluster likelihood mapping.

Conclusions

The independent evolution of LHC and PSBS families is supported by strong phylogenetic evidence. In addition, a possible origin of LHC and PSBS families from different homologous members of the stress-enhanced protein subfamily, a diverse and anciently paralogous group of two-helix proteins, seems likely. The new hypothesis for the evolution of the extended LHC protein superfamily proposed here is in agreement with the character evolution analysis that incorporates the distribution of families and subfamilies across taxonomic lineages. Intriguingly, stress-enhanced proteins, which are universally found in the genomes of green plants, red algae, glaucophytes and in diatoms with complex plastids, could represent an important and previously missing link in the evolution of the extended LHC protein superfamily.
Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse
Authors: Miterko Lauren N. , White Joshua J. , Lin Tao , Brown Amanda M. , O’Donovan Kevin J. , Sillitoe Roy V.
Published: March 2019

Background

Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of hereditary ataxia, severe motor deficits arise despite the cerebellum overcoming initial defects in size and morphology.

Methods

To resolve how this compensation occurs, we asked how the loss of carbonic anhydrase 8 (CAR8), a regulator of IP3R1 Ca2+ signaling in Purkinje cells, alters cerebellar development in Car8wdl mice. Using a combination of histological, physiological, and behavioral analyses, we determined the extent to which the loss of CAR8 affects cerebellar anatomy, neuronal firing, and motor coordination during development.

Results

Our results reveal that granule cell proliferation is reduced in early postnatal mutants, although by the third postnatal week there is enhanced and prolonged proliferation, plus an upregulation of Sox2 expression in the inner EGL. Modified circuit patterning of Purkinje cells and Bergmann glia accompany these granule cell adjustments. We also find that although anatomy eventually normalizes, the abnormal activity of neurons and muscles persists.

Conclusions

Our data show that losing CAR8 only transiently restricts cerebellar growth, but permanently damages its function. These data support two current hypotheses about cerebellar development and disease: (1) Sox2 expression may be upregulated at sites of injury and contribute to the rescue of cerebellar structure and (2) transient delays to developmental processes may precede permanent motor dysfunction. Furthermore, we characterize waddles mutant mouse morphology and behavior during development and propose a Sox2-positive, cell-mediated role for rescue in a mouse model of human motor diseases.
Timing the spinal cord development with neural progenitor cells losing their proliferative capacity: a theoretical analysis
Authors: Azaïs Manon , Agius Eric , Blanco Stéphane , Molina Angie , Pituello Fabienne , Tregan Jean-Marc , Vallet Anaïs , Gautrais Jacques
Published: March 2019

In the developing neural tube in chicken and mammals, neural stem cells proliferate and differentiate according to a stereotyped spatiotemporal pattern. Several actors have been identified in the control of this process, from tissue-scale morphogens patterning to intrinsic determinants in neural progenitor cells. In a previous study (Bonnet et al. eLife 7, 2018), we have shown that the CDC25B phosphatase promotes the transition from proliferation to differentiation by stimulating neurogenic divisions, suggesting that it acts as a maturating factor for neural progenitors. In this previous study, we set up a mathematical model linking fixed progenitor modes of division to the dynamics of progenitors and differentiated populations. Here, we extend this model over time to propose a complete dynamical picture of this process. We start from the standard paradigm that progenitors are homogeneous and can perform any type of divisions (proliferative division yielding two progenitors, asymmetric neurogenic divisions yielding one progenitor and one neuron, and terminal symmetric divisions yielding two neurons). We calibrate this model using data published by Saade et al. (Cell Reports 4, 2013) about mode of divisions and population dynamics of progenitors/neurons at different developmental stages. Next, we explore the scenarios in which the progenitor population is actually split into two different pools, one of which is composed of cells that have lost the capacity to perform proliferative divisions. The scenario in which asymmetric neurogenic division would induce such a loss of proliferative capacity appears very relevant.
Fast approximate STEM image simulations from a machine learning model
Authors: Combs Aidan H. , Maldonis Jason J. , Feng Jie , Xu Zhongnan , Voyles Paul M. , Morgan Dane
Published: March 2019

Accurate quantum mechanical scanning transmission electron microscopy image simulation methods such as the multislice method require computation times that are too large to use in applications in high-resolution materials imaging that require very large numbers of simulated images. However, higher-speed simulation methods based on linear imaging models, such as the convolution method, are often not accurate enough for use in these applications. We present a method that generates an image from the convolution of an object function and the probe intensity, and then uses a multivariate polynomial fit to a dataset of corresponding multislice and convolution images to correct it. We develop and validate this method using simulated images of Pt and Pt–Mo nanoparticles and find that for these systems, once the polynomial is fit, the method runs about six orders of magnitude faster than parallelized CPU implementations of the multislice method while achieving a 1 − R2 error of 0.010–0.015 and root-mean-square error/standard deviation of dataset being predicted of about 0.1 when compared to full multislice simulations.
Recent advances in the development of gene delivery systems
Authors: Sung YK , Kim SW
Published: March 2019

Background

Gene delivery systems are essentially necessary for the gene therapy of human genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to cure any disease. The gene therapy is one of promising therapies for a number of diseases such as inherited disorders, viral infection and cancers. The useful results of gene delivery systems depend open the adjustable targeting gene delivery systems. Some of successful gene delivery systems have recently reported for the practical application of gene therapy.

Main body

The recent developments of viral gene delivery systems and non-viral gene delivery systems for gene therapy have briefly reviewed. The viral gene delivery systems have discussed for the viral vectors based on DNA, RNA and oncolytic viral vectors. The non-viral gene delivery systems have also treated for the physicochemical approaches such as physical methods and chemical methods. Several kinds of successful gene delivery systems have briefly discussed on the bases of the gene delivery systems such as cationic polymers, poly(L-lysine), polysaccharides, and poly(ethylenimine)s.

Conclusion

The goal of the research for gene delivery system is to develop the clinically relevant vectors such as viral and non-viral vectors that use to combat elusive diseases such as AIDS, cancer, Alzheimer, etc. Next step research will focus on advancing DNA and RNA molecular technologies to become the standard treatment options in the clinical area of biomedical application.
Sacroiliac Joint Pain in Pregnancy: A Case Report
Authors: Vincent Ryan , Blackburn John , Wienecke Gretchen , Bautista Alexander
Published: March 2019

Sacroiliac joint pain is one of the most common causes of low back pain in pregnant women. We present a case of a 30-year-old G2P1 at 20 weeks gestation presenting with intractable low back pain refractory to conservative management. History and physical examination revealed sacroiliac joint as the pain generator. We elected to do an ultrasound-guided sacroiliac joint injection that significantly abated her pain. This article aims to review the diagnosis, pathophysiology, and treatment approaches to adequately manage sacroiliac joint pain in pregnant women.
MRI evaluation of pelvis in Mayer–Rokitansky–Kuster–Hauser syndrome: interobserver agreement for surgically relevant structures
Authors: Bhayana Aanchal , Ghasi Rohini Gupta
Published: March 2019

Objectives:

Diagnostic role of MRI in Mayer–Rokitansky–Kuster–Hauser (MRKH) syndrome is well documented. Recent studies have shown the relevance of MRI in detailing the pelvic anatomy, particularly small Mullerian remnants. The results are, however, not consistent and reproducibility of MRI features has not been confirmed. The aim of our study was to evaluate the detailed pelvic anatomy in patients with MRKH syndrome and to calculate the interobserver agreement of the MRI features.

Methods:

The study was carried out on female patients, aged 15–30 years, with primary amenorrhea. Following clinical, gynaecological, endocrinological, ultrasound and chromosomal work-up and a provisional diagnosis of MRKH syndrome, MRI pelvis was performed on 25 patients using a 1.5 T scanner. MRI images were retrospectively reviewed by two radiologists for a detailed evaluation of Mullerian structures (uterine buds, fibrous bands, midline triangular soft tissue), vagina, and ovaries. κ coefficient was calculated as a measure of interobserver agreement.

Results:

Interobserver agreement was good to excellent (κ: 0.7788 ± 0.2168 to 1 ± 0) for uterine buds and their characteristics, vagina, ovaries and associated renal/vertebral anomalies; poor to fair for fibrous bands (κ: 0.2857 ± 0.3273 to 0.6032 ± 0.2149) and good for midline triangular soft tissue (κ: 0.7826 ± 0.1474).

Conclusion:

MRI is capable of providing key pre-operative anatomical information in MRKH syndrome non-invasively. There is good to excellent interobserver agreement for MRI features of most of the surgical relevant structures.

Advances in knowledge:

MRI features of salient preoperative anatomical structures are reproducible between observers.
Influence of cone beam CT volume orientation on alveolar bone measurements in patients with different facial profiles
Authors: Costa Eliana Dantas , Peyneau Priscila Dias , Ambrosano Glaucia Maria Bovi , Oliveira Matheus Lima
Published: March 2019

Objectives:

To evaluate the influence of cone beam CT (CBCT) volume orientation on alveolar bone measurements for dental implant planning using CBCT in patients with different facial profiles.

Methods:

74 CBCT volumes were selected from a database and classified according to the facial profile of the patient. Height and width measurements of the alveolar bone were carried out with the volume of the mandible in two different orientations: occlusal plane and mandibular base parallel to the horizontal plane. The data were subjected to the mixed model methodology for repeated measures, through the PROC MIXED procedure. Multiple comparisons were performed by Tukey Kramer test (α = 0.05).

Results:

Alveolar bone width was significantly greater when the CBCT volume was oriented with the mandibular base parallel to the horizontal plane, for all facial profiles (p ≤ 0.05). Alveolar bone height was significantly higher (p ≤ 0.05) for dolichofacial individuals when compared to that of mesofacial and brachyfacial individuals, who did not differ significantly between each other (p > 0.05), regardless of the CBCT volume orientations used in this study.

Conclusions:

CBCT-based alveolar bone width is increased when the image volume is oriented with the mandibular base parallel to the horizontal plane and dolichofacial individuals present greater alveolar bone height.
Recent advances in understanding and managing adenomyosis
Authors: Vannuccini Silvia , Petraglia Felice
Published: March 2019

Adenomyosis is a benign uterine disorder in which endometrial glands and stroma are pathologically demonstrated in the uterine myometrium and it is considered a specific entity in the PALM-COEIN FIGO (polyp; adenomyosis; leiomyoma; malignancy and hyperplasia; coagulopathy; ovulatory dysfunction; endometrial; iatrogenic; and not yet classified – International Federation of Gynecology and Obstetrics) classification of causes of abnormal uterine bleeding (AUB). Although it has always been considered the classic condition of multiparous women over 40 years old who have pain and heavy menstrual bleeding, diagnosed at hysterectomy, the epidemiological scenario has completely changed. Adenomyosis is increasingly identified in young women with pain, AUB, infertility, or no symptoms by using imaging techniques such as transvaginal ultrasound and magnetic resonance. However, there is no agreement on the definition and classification of adenomyotic lesions from both the histopathology and the imaging point of view, and the diagnosis remains difficult and unclear. A uniform and shared reporting system needs to be implemented in order to improve our understanding on imaging features, their relationship with pathogenic theories, and their importance in terms of clinical symptoms and response to treatment. In fact, adenomyosis pathogenesis remains elusive and not a single theory can explain all of the different phenotypes of the disease. Furthermore, adenomyosis often coexists with other gynecological conditions, such as endometriosis and uterine fibroids, increasing the heterogeneity of available data. Treatment requires a lifelong management plan as the disease has a negative impact on quality of life in terms of menstrual symptoms, fertility, and pregnancy outcome and has a high risk of miscarriage and obstetric complications.
A curated transcriptome dataset collection to investigate the blood transcriptional response to viral respiratory tract infection and vaccination.
Authors: Bougarn Salim , Boughorbel Sabri , Chaussabel Damien , Marr Nico
Published: March 2019

The human immune defense mechanisms and factors associated with good versus poor health outcomes following viral respiratory tract infections (VRTI), as well as correlates of protection following vaccination against respiratory viruses, remain incompletely understood. To shed further light into these mechanisms, a number of systems-scale studies have been conducted to measure transcriptional changes in blood leukocytes of either naturally or experimentally infected individuals, or in individual’s post-vaccination. Here we are making available a public repository, for research investigators for interpretation, a collection of transcriptome datasets obtained from human whole blood and peripheral blood mononuclear cells (PBMC) to investigate the transcriptional responses following viral respiratory tract infection or vaccination against respiratory viruses. In total, Thirty one31 datasets, associated to viral respiratory tract infections and their related vaccination studies, were identified and retrieved from the NCBI Gene Expression Omnibus (GEO) and loaded in a custom web application designed for interactive query and visualization of integrated large-scale data. Quality control checks, using relevant biological markers, were performed. Multiple sample groupings and rank lists were created to facilitate dataset query and interpretation. Via this interface, users can generate web links to customized graphical views, which may be subsequently inserted into manuscripts to report novel findings. The GXB tool enables browsing of a single gene across projects, providing new perspectives on the role of a given molecule across biological systems in the diagnostic and prognostic following VRTI but also in identifying new correlates of protection. This dataset collection is available at: http://vri1.gxbsidra.org/dm3/geneBrowser/list.
FEATURES OF APOPTOSIS, FORMATION OF MEMBRANE-RELEASED MICROPARTICLES AND CYTOKINES PRODUCTION IN CASE OF LYMPHOCYTE DAMAGE IN SYNTROPY OF BRONCHIAL ASTHMA AND OBESITY IN YOUNG PATIENTS
Authors: Соловьева Ирина , Soloveva Irina , Демко Ирина , Demko Irina , Собко Елена , Sobko E. , Малиновская Н. , Malinovskaya N. , Крапошина Ангелина , Kraposhina Angelina , Гордеева Н. , Gordeeva N.
Published: March 2019

The aim of the research was to study the characteristics of apoptosis, membrane-released microparticles (MRM) formation and cytokines production in case of lymphocyte damage in young patients with bronchial asthma, depending on body mass index. 224 people were examined. In all the patients there was done an assessment of the excessive weight and determination of obesity degree as well as clinical and functional examination; there was performed a determination of cytokines and adipokines; the lymphocytes were separated from the peripheral blood. The number of apoptotic cells was estimated in accordance with the standard protocol; the number of MRM was counted. It was found out that in case of bronchial asthma and obesity syntropy, even at a young age, more often there are patients with moderate and severe clinical course; besides, the severity of bronchial-obstructive syndrome in patients of this group is more significant with the tendency to decrease in FEV1 and FEV1/FVC. In the group of young patients with obesity combined with bronchial asthma in the peripheral blood there was imbalance of both adipokines and cytokines, characterized by evident increase in the levels of pro-inflammatory leptin, IL-4, IL-6, TNF-α, and the decrease in potential body weight regulator IL-15, and at the same time low levels of anti-inflammatory adiponectin. In patients with obesity, the percentage of cells in apoptosis was significantly lower compared to both those in control with obesity and patients with normal body weight. The number of MRM, as cell damage indicator, significantly increased in the group with obesity. It can be assumed that the imbalance of cytokines, adipokines and mechanisms of programmed cell death is a possible pathogenetic factor in asthma and obesity syntropy.
Medicalização da queixa escolar e o uso de psicofármacos como resposta à questões comportamentais
Authors: Silva Cristiane Moreira da , Rodrigues Rafael Coelho , Mello Letícia Nascimento
Published: March 2019

Este artigo apresenta os resultados de pesquisa documental realizada nos arquivos da Assessoria de Psicologia Escolar da Secretaria de Educação do Município de Petrópolis, com a finalidade de investigar o uso de psicofármacos em crianças com queixa escolar. Do total de crianças atendidas, um percentual elevado fazia uso de psicofármacos como resposta aos comportamentos considerados problemáticos pelas escolas. Sendo assim, a pesquisa realizou um levantamento que tornou possível identificar e rastrear a presença de diagnósticos e uso indeterminado de psicofármacos em crianças em decorrência de queixas comportamentais, com o intuito de investigar a possível apropriação das instituições escolares dos discursos medicalizantes e, consequentemente, os diagnósticos e terapêuticas biomédicas para questões escolares.
Um cuidado tecido em rede: versões de um atendimento clínico na graduação de psicologia
Authors: Araujo Erika Da Silva , Quadros Laura Cristina de Toledo
Published: March 2019

Este trabalho debruça-se sobre uma experiência clínica em psicologia a partir do estágio e acompanhamento de um caso clínico no Serviço de Psicologia Aplicada em uma universidade pública do Rio de Janeiro. Nosso principal objetivo é o mapeamento das redes de cuidado que suportam esse atendimento, utilizando para tal a Teoria Ator-Rede, tendo como fio condutor a Lógica do Cuidado proposta por Mol (2008). O caso descrito é narrado através de experiências vivenciadas pela cliente, que retratam diferentes redes onde essa cliente atuou. Compreendendo que o cuidado na psicoterapia individual não acontece exclusivamente na relação terapeuta-cliente, mas pode transbordar por outros espaços, buscamos realizar uma reflexão acerca das práticas de cuidado como um processo que acontece articulado a uma rede, incluindo humanos e não humanos. Nessa escrita, tangenciamos a formação em psicologia e alguns pressupostos da Gestalt-terapia, abordagem que orientou o referido atendimento clínico.
O Sujeito e a Fala em Psicopatologia: Aportes Sobre a Foraclusão
Authors: Ghilardi Ricardo Bertazzo , D'Agord Marta Regina de Leão
Published: March 2019

Neste trabalho apresentamos uma contribuição ao estudo da especificidade da escuta psicanalítica na prática clínica. Iniciamos com uma análise histórica do termo foraclusão e da leitura que Lacan fez da concepção freudiana do processo de Verwerfung. Interessa mostrar a aproximação entre o sujeito foracluído da ciência, a constituição do sujeito na fala e o modelo topológico do corte. Trata-se de indagar sobre a estrutura na qual o sujeito está simbolicamente representado, e na qual, ao mesmo tempo, ele faz parte.  Nesse sentido, o termo indiscriminado sujet responde tanto ao uso gramatical quanto ao topológico. Trabalhamos através de um caso clínico a diferença entre uma clínica do fenômeno e uma clínica da escuta, cujo efeito é um sujeito.
Mujeres en los Archivos de pedagogía y ciencias afines (1906-1914)
Authors: Ostrovsky Ana Elisa
Published: March 2019

A Seção Pedagógica da Faculdade de Ciências Jurídicas da Universidade da Plata foi ao inicio do século XX um importante centro de investigações pedagógicas e psicológicas. Os Archivos de Pedagogía y Ciencias Afines (1906-1914), logo Archivos de Ciencias de la Educación (1914-1920), foi a responsável pela divulgação dos estudos feitos na dita seção. No presente trabalho apresentamos as participações femininas, os perfis dos autores e as características de suas obras.
A "Natureza Feminina" na Ótica dos Médicos, Operários e Literatos no Início do Século XX
Authors: Siqueira Beatriz Colabone , Boarini Maria Lucia
Published: March 2019

O objetivo deste estudo é refletir sobre a concepção de mulher veiculada pela literatura, pela imprensa operária e pela imprensa científica no Brasil no início do século XX. Para isso, foram utilizadas como fontes primárias e principais o jornal operário A Plebe (1917-1951),os Archivos Brasileiros de Hygiene Mental (1925-1947) e dois romances nacionais: Parque Industrial (1933) de Patrícia Galvão e O Quinze (1930) de Rachel de Queiroz. As fontes históricas de qualquer natureza têm importância fundamental para a pesquisa, uma vez que são consideradas testemunhas dos momentos históricos em que foram produzidas, e por isso, amparam a produção do conhecimento acerca de determinado período. Os resultados indicam que imperava um ideal de mulher pautado na existência de uma natureza feminina que significa a aptidão natural da mulher para o cuidado com o lar e com os filhos.
A participação do pai no parto domiciliar planejado: um ato significativo para a mulher
Authors: Quitete Jane Baptista , Monteiro Jéssika Andrade de Melo Braga
Published: March 2019

Objetivo: discutir a participação do pai durante o trabalho de parto e parto sob a ótica da mulher. Método: pesquisa de natureza qualitativa, realizada entre 2014 e 2015, utilizando entrevistas semiestruturadas, com oito mulheres que tiveram parto domiciliar planejado e assistido por enfermeiras obstétricas no Estado do Rio de Janeiro. O projeto foi aprovado por Comitê de Ética em Pesquisa. Os depoimentos foram tratados por análise de conteúdo. Resultados: a análise dos dados evidenciou uma categoria temática denominada: significando a presença paterna, na qual se observa a importância do apoio paterno para a mulher, favorecendo o nascimento de forma mais natural e gerando sentimentos de segurança e amparo às mulheres. Conclusão: a participação do pai durante o trabalho de parto e parto foi considerada fundamental para as mulheres.
A maternidade de mulheres cegas: possíveis contribuições de enfermagem.
Authors: Santos Rosângela Da Silva , Ribeiro Vivian Mara
Published: March 2019

Objetivo: identificar o estado da arte do contexto da maternidade de mulheres cegas. Método: realizou-se revisão integrativa através de busca on-line de artigos indexados em periódicos do sítio Portal de Periódicos Capes e da Biblioteca Virtual em Saúde, utilizando termos em português e seus correspondentes em inglês: mães e deficiência visual e mãe cega. Adotou-se como critérios de inclusão para a seleção: todos os artigos publicados entre 2000 e 2016, em português e inglês, disponíveis na íntegra, com enfoque na deficiência visual e maternidade. Resultados: a comunicação e interação mãe/filho é foco entre os estudos que abordam a maternidade de mulheres cegas. Conclusão: a realização de estudos sobre as mães cegas, seus anseios, suas experiências de vida com relação a elas mesmas e a seu novo papel social pode fortalecer e aprimorar o cuidado em saúde e indicar para quais aspectos a enfermagem pode efetivamente direcionar o cuidado em saúde.
What is the paramedic's role in smoking cessation?
Authors: Wilson Sophia , Hill Lawrence
Published: March 2019

Background:

Both the National Institute for Health and Care Excellence (NICE) and Public Health England have made smoking cessation a health promotion priority but the paramedic's potential impact in this important area has yet to be fully realised.

Aim:

This article proposes an evidence-based quality improvement intervention that can be adopted by paramedics at an individual, service-wide or national level to promote smoking cessation.

Methodology:

Building on a structured literature review and using the three fundamental questions and a Plan Do Study Act cycle, we propose a quality improvement strategy and evaluation methodology suited to the aims of the article.

Discussion:

Very Brief Advice is an evidence-based, effective and time-efficient way of reducing harm from smoking and improving quality of life for patients, saving NHS money as well as increasing paramedic job satisfaction.
Peramalan Banyaknya Pengunjung Pantai Glagah Menggunakan Metode Autoregressive Integrated Moving Average Exogenous (ARIMAX) dengan Efek Variasi Kalender
Authors: Intan Solikhah Novita , Zukhronah Etik , Wibowo Supriyadi
Published: March 2019

Glagah Beach is one of the tourist destinations in Kulon Progo Regency, Yogyakarta which is the most visited by tourists. Glagah Beach visitors data show  that in the month of Eid Al-Fitr there was a significant increase. This shows that there is an effect of the calendar variation of Eid al-Fitr. Therefore, it is needed a method that can be used to analyze time series data which contains effects of calendar variations, that is ARIMAX method. The aim of this study are to find the best ARIMAX model and to predict the number of visitors to Glagah Beach in the future. The result shows that the best ARIMAX model was ARIMAX([24],0,0). Forecasting from January to September 2016 are 37211, 21306, 26247, 24148, 28402, 29309, 81724, 26029, and 23688 visitors.
 Keywords: Glagah Beach; variation of calendar; Eid al-Fitr; ARIMAX.
The naked designer: Changing the self
Authors: Maggio Tommaso
Published: March 2019

As a designer, in order to fully comprehend the community where I work, I have to shift my attention from creating objects to build relationship; by doing so I have transformed myself as node of an expanding network of people and knowledge. This does not mean that I reject the objects that I have realized within the collaborations of artisans, institutions and local entrepreneurs, but rather that I give more importance to reviewing the process of designing. I comprehend that it is a cumulative procedure raised by the necessity of understanding the new–normal context that I have embraced in the last few years. Here, outcomes if physical are then to be considered a shell of a temperament raised by the encounters within moral and social elements. As a profession, design evolves and moves from a solo, collective to a participative approach; it is relevant to underline here that in my perspective co-design, it is a process that aims to fabricate physicality as a sum of encounters and dialogues with other people. The process can be read as a response to visual stimuli. By unfolding the narrative of persuading this path, the article looks at cultural studies and it evolves the role of design profession in the momentum flux. Case studies conceived as world-view translate to corporate as site-specific point of view are then deconstructed in this article as sections of a rhizomatic process that is still in process. The article draws the lines between context and people where the objects are responses to the built relation.
Estudo da ação emulsificante da polpa de abacate associada às proteínas do soro de leite
Authors: Coelho Marta De Oliveira , Rezende Suélen De Oliveira , Pena Mariana Gavioli dos Reis , Costa Fabiano Freire
Published: March 2019

O abacate é uma fruta rica em gorduras monoinsaturadas. O soro lácteo apresenta ação emulsificante e a sua combinação com outros componentes naturais pode ser potencializada formando novos produtos estáveis e atrativos ao consumidor. O presente estudo avaliou se a polpa de abacate poderá agir como agente emulsificante na fase oleosa de uma emulsão para fins alimentícios. Foi preparada uma emulsão básica com e sem a polpa de abacate. Estas emulsões foram pasteurizadas e microfluidizadas (Mixer e Turrax). Foram realizados testes de estabilidade (com e sem variações de temperaturas) e condição de armazenamento, teste de escoamento, liofilização, caracterização das amostras por tamanho de partícula e análise microscópica. Os resultados mostraram que a estabilidade da emulsão com abacate foi inferior à emulsão base. No estudo de escoamento as amostras das emulsões com abacate tiveram uma maior quantidade de massa perdida. Foi comprovada que houve um aumento da viscosidade pela ação emulsificante proveniente da polpa de abacate e ocorreu uma redução do tamanho das partículas dessa emulsão.
Temperatura de armazenamento e qualidade microbiológica do leite cru granelizado na região de Rio Pomba, Minas Gerais
Authors: Condé Patrícia Rodrigues , Pinto Cláudia Lúcia de Oliveira , Gandra Scarlet Ohana da Silva , Silva Roselir Ribeiro da , Martins Maurilio Lopes
Published: March 2019

A refrigeração do leite cru em tanques de granelização representa um entrave na cadeia produtiva do leite associado à seleção de bactérias psicrotróficas deterioran tes com consequências negativas para a indústria. Objetivou-se avaliar a temperatura e a qualidade microbiológica de leite cru armazenado em 15 tanques de refrigeração do município de Rio Pomba, MG, nas estações do ano, entre outubro de 2016 e julho de 2017. A temperatura do leite em cada tanque foi determinada no momento da coleta das amostras. Posteriormente, realizou-se a contagem de microrganismos mesófilos aeróbios, psicrotróficos, psicrotróficos proteolíticos, psicrotróficos lipolíticos, psicrotróficos produtores de lecitinase e de Pseudomonas sp. Não houve diferença (p > 0,05) de temperatura do leite no momento da coleta entre os 15 tanques de granelização, porém as médias das temperaturas foram acima de 4,0 ºC, portanto em desacordo com a Instrução Normativa n.º 76. A contagem de microrganismos me sófilos aeróbios apresentou variação entre 3,4 a 6,8 Log UFC/mL, sendo que 42% das amostras não estavam em conformidade com o padrão legal. A contagem de microrganismos psicrotróficos apresentou variação entre 3,0 e 8,1 Log UFC/mL com média igual (p > 0,05) à média da contagem de microrganismos mesófilos aeróbios. Mais de 50% das amostras apresentaram contagens de Pseudomonas sp. acima de 4,0 Log UFC/mL. Concluiu-se que as condições higiênico-sanitárias na obtenção de leite cru no município de Rio Pomba, MG, apresentaram-se inadequadas, destacando-se, portanto, a importância da prevenção de contaminação do leite cru por meio da implementação das Boas Práticas na cadeia produtiva.
Platform Teknolojileri ve Temsiliyet Sorunu: Uber ve Booking.com Vakaları
Authors: TEKİN BİLBİL Ebru
Published: March 2019

Booking.com ve Uber firmaları vaka analizlerine odaklanmaktadır. Bu çalışma ile, bu firmalarınfaaliyet gösterdikleri piyasaların yapısını değiştirmesi, çıkar ilişkilerini tetiklemesi ve yeni müdahalealanları yaratması irdelenirken bu alanlarda ortaya çıkan temsiliyet sorunları incelenmektedir.Booking.com ve Uber’in bu çalışma dahilinde vaka örnekleri olarak seçilmesinin sebepleri arasındaiki firmanın da Türkiye’de yasal takipte olması; geleneksel piyasaya karşı yenilikçi uygulamalara sahipolmaları; dünyada da bu firmalar ile ilgili farklı yasaklama ve yasal düzenleme getirilmiş olması yeralmaktadır. Literatürde, dijital platformların yasal değişimleri nasıl kışkırttığına ilişkin olarak dörtyöntem kategorize edilmektedir. Bu yöntemler şu şekildedir: (1) Yasayı ihlal etmek ya da yasalardankaynaklanan gri alanlardan istifade etmek; (2) Piyasada yasaklanamayacak kadar bir büyüme sağlamak;(3) Tüketicileri ve diğer paydaşları siyasi güç için harekete geçirmek; (4) Daha ziyade geleneksel siyasiteknikler uygulamak. Söz konusu bu çalışma temsiliyet sorununun formal olan ve formal olmayan ilesiyasi ve politik ikilemlerinin ötesinde dijital platform firmalarının nasıl muğlak, çetrefilli ve belirsizyeni siyaset alanlarını oluşturduğu ve yine bu alanlardaki müdahale süreçlerinde nasıl daha çetrefillitemsiliyet problemleri yarattığını incelemektedir. Ayrıca, bu çalışma, sözü geçen siyaset alanlarıiçerisindeki aktörlerin koşullara bağlı yaklaşım ve etkileşimlerini temsiliyet sorunu çerçevesindeirdelerken, bu hizmetlerden mahrum kalan gruplar açısından temsiliyet boşlukları olduğunu ortayaçıkarmaktadır. Meslek birliklerinin, yenilikçi teknoloji ve yeni ekonomi piyasası temsiliyetindeboşluklar yaratacak şekilde çıkar faaliyetlerine girerek temsiliyet boşlukları yarattığı görülmektedir.Bu temsiliyet boşluğu aynı sektördeki STK’lar arasında da çatışma alanları yaratmaktadır. Bu analizışığında, temsiliyet sorunu 6 faktör açısından söz konusu vaka analizleri üzerinden sonuçlandırılabilir.Bu faktörler şu şekildedir: (1) Kurumsal tercihler, (2) Kimin katıldığı, (3) Kimin dışlandığı, (4) Nasılkatılım sağlandığı, (5) Katılımın gerekçeleri, (6) Sonuç üzerindeki etki. Buna göre, çalışma şu sonuçları ortaya çıkarmıştır: (1) Türkiye’de dijital platform firmaları özelinde onların da haklarını koruyucubir regülasyon olmaması; (2) Yeni teknolojilerin tetiklediği regülasyonların farklı müdahale alanlarıve ilişki formları yaratması; (3) Seçimle gelen tepeden-aşağıya temsiliyet ile betimsel ve semboliktemsiliyet arasında yeni iletişim, yönetişim ve etkileşim alanlarının geliştirilmesi gereği. Bu çalışmavaka analizi metodunu benimserken kalitatif görüşmeler, telefon mülakatları ve katılımcı gözlemler iledoküman analizlerine dayanmaktadır.
Why did They Leave? Perceptions on the Turkish Emigration from Dobrogea to Turkey (1918-1940)
Authors: OMER Metin
Published: March 2019

In this paper I try to present the perceptions of a process that marked not only the evolution of therelations between two countries (Romania and Turkey) but also determined some important socialchanges in the Turkish-Tatar community from Dobrogea, Romanian province known as Dobrudja inthe Turkish historiography. In order to obtain an accurate image we used in our research documentsfrom Romanian and Turkish archives, Romanian press, Turkish press and the press of Turkish-Tatarcommunity from Dobrogea. In our analysis we consider Dobrogea, the main region of Romania whereTurks and Tatars leave, a “contact zone”, a term used by Mary Louise Pratt (1992: 4) for “social spaceswhere disparate cultures meet, clash, and grapple with each other”. We also consider the emigration fromDobrogea to Turkey in the interwar as part of “balkanlaşma göçleri” (Balkanization migration), a termused by Turkish researcher İlhan Tekeli to designate the emigration from the ex-Ottoman territoiresin the Balkans to Anatolia (or more specifically within the new borders of Ottoman Empire/TurkishRepublic). Tekeli (2013: 44-45) argues that “Balkanization migration” has a direct connection with theprocess of formation of the national states in the Balkans.
Morphology, molecular phylogeny and toxinology of Coolia and Prorocentrum strains isolated from the tropical South Western Atlantic Ocean
Authors: de Queiroz Mendes Maria Cristina , de Castro Nunes José Marcos , Fraga Santiago , Rodríguez Francisco , Franco José Mariano , Riobó Pilar , Branco Suema , Menezes Mariângela
Published: March 2019

The morphology, molecular phylogeny and toxinology of two Coolia and one Prorocentrum dinoflagellate strains from Brazil were characterized. They matched with Coolia malayensis and Coolia tropicalis morphotypes, while the Prorocentrum strain fitted well with the morphology of Prorocentrum emarginatum. Complementary identification by molecular analyses was carried out based on LSU and ITS-5.8S rDNA. Phylogenetic analyses of Coolia strains (D1/D2 region, LSU rDNA), showed that C. malayensis (strain UFBA044) segregated together with sequences of this species from other parts of the world, but diverged earlier in a separate branch to sequences from São Paulo (Brazil) or Caribbean areas. Coolia tropicalis (strain UFBA055) grouped with other sequences of this species, in a subclade with an isolate from Belize, closer to a subgroup including isolates from Thailand, Australia and Hong Kong. Phylogenetic analyses (ITS-5.8S rDNA) of P. emarginatum (strain UFBA033) grouped together with another sequence of this species from China Sea. Diarrhetic shellfish poisoning toxins (OA, DTXs and PTX2) were not detected in P. emarginatum by mass spectrometry analyses. However, hemolytic assays in P. emarginatum and both Coolia strains in this study showed positive results.
Identification of chemical constituents from the bark of Larix kaempferi and their tyrosinase inhibitory effect
Authors: Kakumu Yuya , Yamauchi Kosei , Mitsunaga Tohru
Published: March 2019

Most of the wood bark produced by the forestry production is discarded in spite of containing many kinds of the phytochemical ingredients. The aim of the present study was to identify secondary metabolites from the bark of Larix kaempferi generated as waste material and evaluate their potential as cosmetic agents. Eighteen compounds, including a novel phenanthrene, 4,6,7-trihydroxyphenanthrene-2-O-β-D-glucopyranoside (16), were isolated from the bark of L. kaempferi and identified by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS) and nuclear magnetic resonance (NMR). In addition, the tyrosinase inhibitory activity of these compounds was evaluated. Procyanidin B7 (18) exhibited the most potent inhibition with IC50 values of 31.0 μM and 61.8 μM when using L-tyrosine and L-dopa as the substrate, respectively, which were similar to those of the positive control, kojic acid. Interestingly, quercetin-3-O-α-L-rhamnopyranoside (10) was shown to possess the tyrosinase inhibition although the other series of 3-glycoylated flavonols were not active, suggesting that the rhamnosyl group at C-3 and the hydroxyl group at C-3ʹ played an indispensable role in the anti-tyrosinase activity. These findings indicate that a number of constituents from L. kaempferi bark may have potential as additives in cosmetics.
Bismuth-based metamaterials: from narrowband reflective color filter to extremely broadband near perfect absorber
Authors: Ghobadi Amir , Hajian Hodjat , Gokbayrak Murat , Butun Bayram , Ozbay Ekmel
Published: March 2019

In recent years, sub-wavelength metamaterials-based light perfect absorbers have been the subject of many studies. The most frequently utilized absorber configuration is based on nanostructured plasmonic metals. However, two main drawbacks were raised for this design architecture. One is the fabrication complexity and large scale incompatibility of these nano units. The other one is the inherent limitation of these common metals which mostly operate in the visible frequency range. Recently, strong interference effects in lithography-free planar multilayer designs have been proposed as a solution for tackling these drawbacks. In this paper, we reveal the extraordinary potential of bismuth (Bi) metal in achieving light perfect absorption in a planar design through a broad wavelength regime. For this aim, we adopted a modeling approach based on the transfer matrix method (TMM) to find the ideal conditions for light perfect absorption. According to the findings of our modeling and numerical simulations, it was demonstrated that the use of Bi in the metal-insulator-metal-insulator (MIMI) configuration can simultaneously provide two distinct functionalities; a narrow near unity reflection response and an ultra-broadband near perfect absorption. The reflection behavior can be employed to realize additive color filters in the visible range, while the ultra-broadband absorption response of the design can fully harvest solar irradiation in the visible and near infrared (NIR) ranges. The findings of this paper demonstrate the extraordinary potential of Bi metal for the design of deep sub-wavelength optical devices.
A compact structure for realizing Lorentzian, Fano, and electromagnetically induced transparency resonance lineshapes in a microring resonator
Authors: Gu Linpeng , Fang Hanlin , Li Juntao , Fang Liang , Chua Soo Jin , Zhao Jianlin , Gan Xuetao
Published: March 2019

Microring resonators, as a fundamental building block of photonic integrated circuits, are well developed into numerous functional devices, whose performances are strongly determined by microring’s resonance lineshapes. We propose a compact structure to reliably realize Lorentzian, Fano, and electromagnetically induced transparency (EIT) resonance lineshapes in a microring. By simply inserting two air-holes in the side-coupled waveguide of a microring, a Fabry-Perot (FP) resonance is involved to couple with microring’s resonant modes, showing Lorentzian, Fano, and EIT lineshapes over one free spectral range of the FP resonance. The quality factors, extinction ratios (ERs), and slope rates (SRs) in different lineshapes are discussed. At microring’s specific resonant wavelength, the lineshape could be tuned among these three types by controlling the FP cavity’s length. Experiment results verify the theoretical analysis well and represent Fano lineshapes with ERs of about 20 dB and SRs over 280 dB/nm. The reliably and flexibly tunable lineshapes in the compact structure have potentials to improve microring-based devices and expand their application scopes.
Optimal Resort to Court-Appointed Experts
Authors: Lambert Eve-Angeline , Oytana Yves
Published: March 2019

Departing from the observation that neutral experts are increasingly appointed by courts, this paper investigates the incentives of courts to appoint experts, and the interactions between the judge’s and the expert’s efforts to discover the truth about a given case. Judges seek to make correct decisions and may choose to appoint experts in order to do so. Experts are assumed to be guided by both reputational and truth-finding motives. We highlight the determinants of the judge’s and the expert’s effort levels and of the judge’s decision whether to appoint an expert. We find that the expert’s effort is decreasing in the judge’s effort, which implies potential freeriding from the judge. Moreover, we find that (i) the judge’s effort is generally suboptimal, and (ii) they might resort to an expert appraisal too frequently, thereby contributing to increased court congestion and higher costs for society. Our results therefore suggest that, under conditions that we discuss, it may be socially beneficial to apply a principle of proportionality to the use of expert testimony, depending on the complexity of the case.
Peirce on assertion and other speech acts
Authors: Bellucci Francesco
Published: March 2019

This paper offers a selective but reasonably representative reconstruction of the evolution of Peirce’s “speech acts theory” across different, consecutive versions of speculative grammar. It examines Peirce’s pre-1903 theory of assertion, the Syllabus (1903) and “Καινὰ στοιχεῖα” (c. 1904), and reconstructs Peirce’s speech-act-oriented semiotic classifications after 1904.
Verfahren zur kombinierten Form- und Zentrierprüfung mikrooptischer Asphären mit optischer Kohärenztomographie
Authors: Riediger Max , Schmitt Robert
Published: March 2019

Mikrooptische Asphären aus Kunststoff spielen zunehmend eine Rolle bei Sensing- und Imagingapplikationen. Die messtechnische Charakterisierung dieser Bauteile stellt im Stand der Technik jedoch noch immer eine Herausforderung dar. In dieser Arbeit wird ein auf optischer Kohärenztomographie (OCT) basierendes Verfahren vorgestellt, welches in der Lage ist, die Form- und Zentrierung beider Funktionsflächen mikrooptischer Asphären mit nur einer Messung zu erfassen. Die Herausforderung stellt dabei die Messung der dem Messkopf abgewandten Funktionsfläche dar, da diese aufgrund der Lichtbrechung an der dem Messkopf zugewandten Funktionsfläche verzerrt gemessen wird und mit Hilfe von Raytracing korrigiert werden muss.
Synthesis, crystal structure, and magnetic properties of a multicage compound: [(Me)2EtNH][Mn(N3)3] with a perovskite-related structure
Authors: Yang Jie , Huang Yuan , Fang Ting , Qian Kun , Chen Wen-Bin , Yu Xiu-Feng , Ai Yi-Chun , Ye Jia-Li , Li Xiang-Yun
Published: March 2019

A new multicage compound [(Me)2EtNH][Mn(N3)3] (Me = methyl, Et = ethyl) with a perovskite-related structure has been synthesized. The manganese(II) cations are bridged by end-to-end (EE) azide anions to form three-dimensional cages with the N,N-dimethylethylammonium cations residing in the cavities of the [Mn(N3)3]
n
n

− cages. The compound has been characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis, second-harmonic generation, and magnetic measurements. The second-harmonic generation results support its noncentrosymmetric polar crystal structure. Magnetic susceptibility measurements show antiferromagnetic interactions among the MnII ions.