bluuebunny/crossref_metadata_2025 huggingface dataset:
HUBUNGAN ANTARA KETEPATAN TIMBANG TERIMA PERAWAT DENGAN INSIDEN KESELAMATAN PASIEN RAWAT INAP RUMAH SAKIT X DI MALANG
Authors: Kusumaningrum Winanda Setyo Putri
Published: November 2022

ABSTRAK

Keselamatan pasien merupakan prinsip dasar dari pelayanan kesehatan yang memandang bahwa keselamatan merupakan hak bagi setiap pasien dalam menerima pelayanan kesehatan.T imbang  terima  pasien  adalah  suatu  cara  dalam memberikan laporan  dari  perawat  setiap  shift  sebelumnya  baik  itu  shift  pagi,  siang ataupun  malam  kepada  perawat  shift  selanjutnya  tentang  kejadian  dan  perawatan  yang  telah  diberikan  dan  dijalankan. Tujuan penelitian ini adalah untuk mengetahui hubungan antara ketepatan timbang terima perawat dengan insiden keselamatan pasien rawat inap Rumah Sakit X di Malang. Sampel yang digunakan adalah populasi perawat pelaksana di rawat inap Rumah Sakit X di Malang sebanyak 68 orang . Desain penelitian ini adalah Cross Sectional dengan variabel independen adalah timbang terima pasien dan variabel dependen adalah keselamatan pasien. Analisis bivariat menggunakan uji korelasi Rank Spearman. Hasil penelitian menunjukkan hubungan antara ketepatan timbang terima perawat dengan insiden keselamatan pasien rawat inap Rumah Sakit X di Malang signifikan (sig<0.05). Hubungan tersebut sebesar 25.6% (0.256) bersifat negatif (-) yang berarti semakin tinggi ketepatan timbang terima perawat maka semakin rendah insiden keselamatan pasien. Perawat dengan pelaksanaan timbang terima yang baik dan efektif dapat mencegah terjadinya insiden keselamatan pasien. Diperlukan peningkatan dan kesadaran terhadap kepatuhan dalam melaksanakan Standar Operasional Prosedur (SOP) dan juga supervisi pimpinan sehingga dapat meningkatkan program keselamatan pasien yang ada di rumah sakit.

 

Kata Kunci: Insiden Keselamatan Pasien, Timbang Terima Pasien, Perawat Pelaksana
THE THE EFFECT OF BOWEL MASSAGE ON BODY NOISE FREQUENCY IN POST TREPANATION PATIENTS
Authors: Sinaga Galih Pandu
Published: November 2022

Trepanation is one of the most serious and soul-critical traumas. The main goal of anesthetic management for patients with brain injury is optimization of cerebral perfusion pressure and brain oxygenation. As a result of anesthetic drugs reduce peristalsis in the large intestine and small intestine. Bowel massage is a mechanism of action to reduce contractions and tension in the abdominal muscles, increase motility in the digestive system, increase secretions in the intestinal system and have an effect on sphincter relaxation so that this mechanism of action will facilitate and facilitate expulsion of feces. The universal aim of this research is to identify the comparison of bowel sounds frequency in post trepanation patients between being treated and not being treated in the ICU room at RSUD dr. Saiful Anwar Malang. This study uses a quantitative approach with a Quasi Experimental design with a Non Equivalent Control Group Design approach. The sampling technique used in this research is accidental sampling. Linear regression test between time and bowel sounds in the treatment group obtained a p value of 0.048 (p <0.05), it can be concluded that time has a significant effect on bowel sounds in the treatment group. Test the difference in bowel bissing between the control group with the Mann Whitney test at 3 different times. The p value is (p < 0.05), meaning that there is a difference in bowel sounds after bowel massage.
PENGARUH PEMBERIAN EDUKASI PERSIAPAN PRE OPERATIF MELALUI MULTIMEDIA VIDEO TERHADAP TINGKAT KECEMASAN PADA PASIEN PRE OPERASI ELEKTIF
Authors: Arif Taufan , Fauziyah Mita Nuur , Astuti Erlina Suci
Published: November 2022

Abstrak: Tingkat kecemasan pre-operasi tinggi terbukti meningkatkan hemodinamika pasien sehingga terjadi penundaan operasi. Tujuan penelitian mengetahui pengaruh pemberian edukasi persiapan pre-operatif melalui multimedia video terhadap tingkat kecemasan pada pasien pre-operasi elektif. Desain penelitian menggunakan quasi eksperimental dengan pendekatan one group pre-test post-test design with control group. Variabel penelitian adalah video edukasi pre-operatif dan tingkat kecemasan. Metode pengambilan sampel yaitu purposive sampling dengan 32 responden sebagai sampel sesuai kriteria inklusi dengan 16 responden pada masing-masing kelompok. Uji paired t-test membandingkan rata-rata 2 sampel berpasangan. Uji independent t-test membandingkan 2 sampel tidak berpasangan. Ada pengaruh pemberian edukasi persiapan pre-operatif melalui multimedia video terhadap tingkat kecemasan pada pasien pre-operasi elektif dengan p-value = 0,000 pada paired t-test kelompok perlakuan, sedangkan pada kelompok kontrol menunjukkan p-value = 0,000. Uji independent t-test pra-intervensi menunjukkan p-value = 0,721, sedangkan post-intervensi menunjukkan p-value = 0,000. Edukasi melalui video dapat menurunkan kecemasan pre-operatif secara signifikan karena memanfaatkan lebih banyak indra. Informasi lebih mudah terserap melalui lobus frontal dan jalur korteks, menambah tingkat pengetahuan sehingga menurunkan kecemasan.
A vérnyomás mérése : A fehérköpeny- és az álcázott hypertonia
Authors: Járai Zoltán
Published: November 2022

A hypertonia felismerése fontos, miután az érrendszeri és szívbetegségek okozta halálozáshoz vezető betegségek leggyakoribb, és ezáltal a legjelentősebb kockázati tényezője. A diagnosztika alapja a helyes vérnyomásmérés. A hagyományos rendelői mé­réseken túlmenően bekerültek az irányelvekbe a rendelőn kívüli vérnyomásmérések, így az otthoni és az ambuláns vérnyomás-monitorozás. Ezek nemcsak többlet prognosztikai értékkel rendelkeznek, de elő­nyük, hogy speciális kórformákat (fehérköpeny- és álcázott hypertonia) lehet felismerni használatukkal. Az otthoni mérések ezenfelül javítják a betegek együtt­mű­kö­dését a kezeléssel. A rövid összefoglaló cikk a vérnyomásméréssel kapcsolatos legfontosabb információkat foglalja össze.
A célvérnyomás-tartomány és a hypertonia nem gyógyszeres kezelése
Authors: Barna István
Published: November 2022

A nemzetközi ajánlások, és így a hazai irányelv is, a célvérnyomás-tartomány és nem a célvérnyomásértékek alkalmazását javasolják, hiszen ezek a mindennapi gyakorlatnak is jobban megfelelnek. A magasvérnyomás-betegség kezelésében kiemelt jelentőségű a nem gyógyszeres kezelés (életmód-változtatás, a túlsúly csökkentése, dohányzás abbahagyása, sófogyasztás csökkentése, rendszeres fizikai aktivitás) mielőbbi elkezdése. Fizikai aktivitás legalább hetente három–négy alkalommal javasolt, 30–60 perces időtartamban. Ha­tár­érték-hypertonia esetén a fizikai aktivitás 6/7 Hgmm átlagos vérnyomáscsökkenést eredményez. Ajánlott a normális testtö­meg­index elérése és megtartása (BMI 20–25 között), a napi 5 g alatti nátrium-klorid-fo­gyasztás, nagyobb mennyiségű zöldség, gyümölcs, és kis transzzsírtartalmú tejtermékek, ételek fogyasztása. Javasolt az al­koholfogyasztás mérséklése: kevesebb le­gyen, mint 20–30 g/nap etanol férfiak, és ke­vesebb, mint 10–20 g/nap etanol nők ese­tében. A dohányzó betegeknek leszo­kási tanácsokat kell adni.
Az artériás életkor meghatározásának klinikai jelentősége
Authors: Benczúr Béla , Miklós Zsuzsanna , Kulin Dániel , Nemcsik János
Published: November 2022

Az artériás öregedés fiziológiás, az emberi szervezet idősödésével együtt járó folyamat, ugyanakkor egy adott egyén kronológiai életkorához képest az artériás életkora eltérő lehet. Ennek hátterében genetikai tényezők, sejtbiológiai folyamatok és számos rizikófaktor hatása áll. Annak ellenére, hogy a kockázatbecslési kalkulátorok nélkülözhetetlenek a prevenciós stratégiák megvalósításában, jelentős különbségeket tapasztalhatunk az előre jelzett és a valóban bekövetkező események számában. Emiatt van szükség egy adott egyén individuális kockázatbecslésének további finomítására, erre szolgálnak a biomarkerek. A biomarkerek köztes (surrogate) végpontként szolgálnak, melyek megelőzik, helyettesítik a valódi, kemény végpontú klinikai eseményeket. Számos lehetséges vascularis biomarker szerepe felmerült a primer és a szekunder cardiovascularis prevencióban. Ezek legtöbbje beleillik a korai vascularis öregedés (early vascular aging, EVA) kon­cep­ciójába. Közülük kizárólag a carotis-ultrahangvizsgálat, a boka-kar index és a carotis-femoralis pulzushullám-terjedési sebesség felel meg teljesen a biomarkerekkel szemben támasztott legszigorúbb kri­tériumoknak. Az artériás öregedés folya­ma­ta lassítható, kedvezően befolyásolható a nem gyógyszeres, illetve gyógyszeres ke­zelési stratégiákkal.
A Study on Watching Motivation and Watching Satisfaction of OTT: Focusing on Korean Original Drama
Authors:   The Korean Society of Culture and Convergence, Rim Hoon
Published: November 2022

This study empirically analyzed the watching motivation and satisfaction of college students who showed active media use behavior targeting OTT Korean original dramas, which are attracting attention as OTT core contents. In addition, based on the analysis, we presented implications for the direction of production activation and development to improve the watching satisfaction of OTT Korean original dramas. First, as a result of analyzing the motivation factors for OTT Korean original drama watching by college students, four factor structures were identified: 'companion motive', 'use convenience motive', 'social usefulness motive', and 'learning/information motive'. Second, as a result of analyzing the influence of four factors of OTT Korean original drama watching motivation on watching satisfaction, 'use convenience motive' and 'learning/information motive' were found to be statistically significant, and 'use convenience motive' was the most has been found to have a great influence.
An Analysis of Medium Effect of Learners’ Satisfaction between the Functional Factors and the Learners’ Loyalty in the Metaverse Debate Education
Authors:   The Korean Society of Culture and Convergence, Lim Ju Young
Published: November 2022

The purpose of this paper is to understand The purpose of this research is to identify the medium effect of English learners’ satisfaction between functional factors and leaners loyalty in the use of metaverse. IBM SPSS Statistics Version 24 and AMOS 24 were used as a package for statistical analysis, in order to identify the correlation of research concepts, structural model analysis and boost-strap analysis was conducted to identify the medium effect of juveniles. First, the functional facors of metaverse was analyzed to influence the user satisfaction. Second, learner satisfaction of metaverse learning was analyzed to positively influence the user loyalty. Third, learner satisfaction was analyzed to have a medium effect for the influence of users’ interface and partial control function on loyalty of metaverse learning users. In addition, it was analyzed how convenient system as a functional factor including users’ interface and partial control function needed to be provided to improve learner satisfaction when designing metaverse English learning. In addition, such learning satisfaction turned out to make a medium effect between the functional factors and learners’ loyalty on metaverse English learning.
A Study on the Exhibition of Public Space in Performance Hall Applying the Concept of Museum Theater
Authors:   The Korean Society of Culture and Convergence, Heo bokyung , Lee Min , Lee Juhyun , Hong Youjin
Published: November 2022

This study started with interest in inter-genre fusion through the application of the museum theater concept. To this end, the museum theater concept was applied to the documentary music play <1919 Philadelphia> which was performed three times in 2022, and the exhibition was planned and installed in the lobby of the concert hall. Out of the 20 performances, 9 exhibition and performance visitors were surveyed focusing on their reactions and the effects of inter-genre intersection. The study found that the synergy effect between the media, the need to utilize the content and commemorative and experiential elements, the need to communicate with the audience, and the environment of the exhibition space should be considered. It is expected that the museum theater project will lead to a follow-up study that can verify the degree of understanding and immersion of viewers and the synergy effect between genres.
A Study on the Soundscape of Resistance Appeared in Bruegel's Religious Paintings
Authors:   The Korean Society of Culture and Convergence, NOH SHIHUN
Published: November 2022

The purpose of this study is to examine how Pieter Bruegel de Oude uses sound in his work to secretly and effectively lead his own resistance to the foreign powers of Spain and Catholicism through the analysis of the soundscape of resistance in his religious paintings. Of the total of 45 paintings by this artist, 20 are religious paintings, of which 10 are allusive to the subject of resistance. First, in these paintings, he achieves the purpose of covert resistance through art by marginalizing the “sacred noise” by letting the secular sounds of everyday life bury the noise in it. He also effectively uses sacred noise and secular sounds of everyday life to mask or reinforce the subject of resistance by appropriately placing them in the “figure” or “ground.”
The Position of Prescriptive Grammar Education in the Liberal Arts Writing Class: Focusing on the Expansion of Grammar Awareness
Authors:   The Korean Society of Culture and Convergence, Kim Nammee
Published: November 2022

The purpose of this paper is to propose a plan to cultivate writing ability that establishes the principle of prescriptive grammar education and applies it to text reading and writing. The principles of prescriptive grammar education should be the process of discovering learners' own grammar, learning the system and structure of grammar, reflecting its principles in other language forms, and understanding and expanding the validity of the criteria involved in the macroscopic interpretation framework. Applying the prescriptive grammar education principle to liberal arts writing classes means that these three principles are consistently applied to the acceptance and production of text. Throughout the writing class, learners check their language skills and strategic skills, read the longitudinal and lateral hierarchies between the language items that make up their thoughts, and carry out the meta-cognitive strategy process by thinking for the possibility of expanding the validity of self-interpretation
Dislocated Screen Memory of Gendered Trauma : Wartime Rape Postmemory in Grbavica and Snowy Road
Authors:   The Korean Society of Culture and Convergence, Nam Seung Suk
Published: November 2022

This study compares Snowy Road(2017) in Korea and Grbavica(2005) in Bosnia and Herzegovina and examines then the cinematic dismemberment of 'gendered trauma' related to women as wartime rapists. The following research process was carried out to examine these comparative films and visual culture research. Grbavica and Snowy Road were compared and discussed in turn as the study subjects. Speculation of the comfort women movie Snowy Road is about how the victims of the Japanese military comfort station during World War II are being reproduced as 'dislocated screen memories' by the present and the past. A speculation of the post-Yugoslavian cinema Grbavica is about the ‘postmemory’ related to the victim woman and daughter systematically perpetrated in the rape camp for the purpose of ethnic cleansing during the Bosnian Civil War. The studies of the two works, which focus on the aspects of women's harm caused by war, have been compared and reviewed, and the ethics of 'cosmopolitanism' is enhanced through the consideration of 'dislocated screen memory' of 'gendered trauma'.
Research to Secure Core Competency System and Feasibility
Authors:   The Korean Society of Culture and Convergence, Choi Heoncheol , Kim Soo Dong
Published: November 2022

The purpose of this study is to develop a core competency diagnostic tool. As for the contents of the study, the core competency diagnostic questions were developed and the reliability and validity of the core competency diagnostic questions were analyzed. The research results are as follows. First, 504 diagnostic questions for core competency were produced. Second, university professors and related experts developed 216 preliminary questions out of 504 diagnostic questions. Third, the preliminary questions were revised and supplemented by conducting a facial validity assessment of the preliminary questions for graduates with a doctoral degree in education. Fourth, as a result of analyzing the reliability and validity of the core competency diagnostic tool, it was found that there were no problems with reliability and validity.
A Study on Consciousness of Existence in the Early Poetry of Goh Jung-hee : Focusing on Who is stepping on the winepress alone
Authors:   The Korean Society of Culture and Convergence, Jeong Chihun
Published: November 2022

The purpose of this paper is to look back on the ‘consciousness of existence’ that appeared in Goh Jung-hee’s early poetry and to solidify the development process of the poetic world. As is well known, the discussion of Goh Jung-hee was centered on late poetry with the evaluation that she was a 'pioneer of feminist literature'. Accordingly, early poetry is placed as a part and limit of the process to advance to the later period. However, it is important to keep in mind that early poetry is the ‘starting point’ of Goh Jung-hee’s poetic world. Therefore, this paper approached with a focus on ‘consciousness of existence’ while distanced from ‘Minjung’ and ‘Women’, who can be said to be the core of Goh Jung-hee’s poetic world. As directly mentioned by Goh Jung-hee, the early poetry deals with the problem of existence. Although there has been a mention of this, there has been relatively little discussion in earnest. This paper first examines the background of Goh Jung-hee’s formation of consciousness of existence and then examines ‘transcendental recognition’ and its practice as a concrete aspect.
The True Value of a Journalist's Imagination Novel in the Mid-1920s: Focusing on Yeom Sang-seop's A Waiting Lounge in the Prosecutor's Office and Rotary Press
Authors:   The Korean Society of Culture and Convergence, Kwon Dongwoo
Published: November 2022

This paper intends to try a more active approach and interpretation of the impact of Yeom Sang-seop's journalist activities, which have been attracting attention by researchers, on the creation of novels. As a journalist on “fact/object” and “fictional/subjective”, which have historically been a debate between journalism and reporting, I would like to analyze Yeom Sang-seop's understanding and judgment, and examine the influence of the artist's creative worldview and work in the mid-1920s, the formation of realism literature. In other words, the starting point of this study is that Yeom Sang-seop's worries due to the tension between “object” and “subject” required by journalism in dealing with specific cases have been transferred to fiction creation. By exploring the process in which “objective” and “subjective” intersect and the position as a reporter and identity as a writer intervene to form a novel, I would like to confirm the “true value” of the journalist-shaped novel and approach the source of Yeom Sang-seop's realism literature.
A Study on the Nail Research Trend of the Domestic Society Based on Network Theory
Authors:   The Korean Society of Culture and Convergence, Park Sohyun , Kwon Kihan
Published: November 2022

This study analyzed the research trends centered on 192 keywords, with 96 keywords for 20 years, 60 keywords for 21 years, and 36 keywords for 22 years from 5 academic societies up to the last 3 years (20-22 years) according to the Korean Journal Standards (KCI). The keywords for 22 years are written only in the first half of June. The number of simultaneous occurrences of keywords by year was analyzed for frequency, and network analysis was performed using NodeXL to derive research keywords that are being studied in common at 5 conferences. the results are as follow. First, the research keywords that appeared the most in 20 years were nail design, three-dimensional art, and flat art. In 21, it was nail design, nail art, and three-dimensional art, and in 2022, it appeared as nail design, self-nail, and consumer value. In common, nail design was the center of research. As a result of the network analysis, the sub-elements of nail design showed expression methods, techniques, expression diversity, and patterns.
A Study on the Effects of University Freshman's Self-directed Activity Project and Proposal Writing
Authors:   The Korean Society of Culture and Convergence, Oh Seieun
Published: November 2022

This study attempted to analyze the process of preparing for the future with more creative and problem-solving ability with writing proposals through university freshman’s self-directed activity and writing activity. Through a new class called Dongduk Arete, students go through the process of self-exploration and develop creative ideas in order to lead them to develop themselves more. Each student tries developing a self-directed program based on ideas that fit their circumstances and tastes and writing them as a proposal. As it has been said that a proposal is 'building', not 'writing', proposal writing is an activity that goes beyond simple writing. As writing a proposal is like building up bricks and writing them together one by one, it is a document for realizing an idea, so it is called a 'blueprint' that is made before construction. Planning is a complex blueprint for putting ideas into practice, a bird's eye view, and a plan for carrying out work. The process of university freshmen leading their life through the process of self-exploration and planning it as a document is a work that demonstrates important values for self-growth in future.
A Study on the Functions of Music Narrative in Chinese Animation from the Perspective of John D. White’s Theory of Music Analysis: (1980) as an Example
Authors:   The Korean Society of Culture and Convergence, Zang BaiLing
Published: November 2022

This study researched on Chinese short animation Three Monks as an example based on the functions of music narrative based on John White’s 3-stage model. First, it analyzes the influence of character images from the micro-analysis point of view and the influence of characters’ personality from the point of view of spatio-temporal scene and sound effect. Second, in terms of meso-analysis, it analyzes the core meaning and roles of music in the animation music narrative from the point of view of story theme and music melody. Third, in terms of macro-analysis, it analyzes the narrative development role of music in animation content development from the viewpoint of combination of story content and music structure. The result shows that music plays a very important role in the narrative of the animation Three Monks. In addition, traditional Chinese music narrative has become one of the features of Chinese animation style.
A Study on the Effect of Reducing the Sleep Latency in Men and Women over 50 Years of Age by using ‘Hypnosis’ Sleep Induction Music
Authors:   The Korean Society of Culture and Convergence, Kang Yoonjeong , Jeon Yoonhan
Published: November 2022

This study was conducted to examine the effect of 'hypnosis', a music designed for sleep, on sleep latency and sleep quality. The subjects of the study were adult men and women aged 50 or older. In order to find out the effect of sleep induction music, the same questionnaire was used to investigate the sleep latency and sleep quality before and after listening to sleep induction music, and then analyzed using SPSS 25.0. As a result of the study, there were no significant differences in sleeping difficulty due to physical symptoms and sleeping environment, sleeping difficulty owing to depression, anxiety, fear, tension, restlessness, and worry about not being able to fall asleep, taking medications, work concentration difficulties because of insomnia, daytime drowsiness and fatigue due to insomnia, and overall sleep quality. However, there was a significant difference in sleep latency before and after the listening period, confirming that sleep induction music shortened the sleep latency.
Research Trends of Group Counseling Program for University Students: Focused on Academic Journal from 2010-2022
Authors:   The Korean Society of Culture and Convergence, Chun kyungsook , Jeong Moonkyeong
Published: November 2022

The purpose of this study is to compare and analyze research topics according to research trends in college student group counseling programs by dividing the time when COVID-19 spread in Korea (2010-2019 and 2020-2022). As for the trend of this study, a total of 90 papers from domestic academic journals were selected under the keywords 'university student' and 'group counseling' in RISS. As a result of the study, it was confirmed that the career path of college students before the outbreak of COVID-19 and emotions (depression, anxiety, etc.) after the outbreak of COVID-19 were the central topics of the group counseling program. This study suggested the need to develop various programs that can enhance the positive emotions of college students in the future group counseling program development.
Soviet Ethnography in the History of State-Building and National Policy: A Collective Monograph
Authors:   Russian Academy of Science N.N.Mikluho-Maklay Institute of Ethnology and Anthropology, martynova Marina , Tishkov Valery
Published: November 2022

he authors focus on the role of the science of nations (ethnology, more precisely according to the terminology of the time - ethnography) in nation-building in the Soviet era, its applied significance and practical functions. The influence of scientists on state management practices and the dynamics of life of the peoples living therein during the Soviet period is investigated. The treatment of interactions between science and politics is based on the analysis of conceptual approaches and topics related to the "national question" (social scientists' contribution to the formulation of criteria for ethnic identity, the interaction of linguistic and economic-geographical issues with the ethnic factor, organization of general censuses, creation of museum expositions, etc.). A thorough review of regional historiography is given, and the research tools of Soviet ethnography are characterized. The authors question the role of people's project activities in the historical process, the significance of the implementation of purposeful plans and programs by the efforts of states, large groups and individuals.
Interferon-gamma release assays for diagnosis of latent TB infection in chronic kidney diseases and dialysis patients
Authors: Hayuk Pattorn , Boongird Sarinya , Pornsuriyasak Prapaporn , Bruminhent Jackrapong
Published: November 2022

Introduction

Patients with chronic kidney disease (CKD), especially end-stage kidney disease (ESKD), are at risk of developing tuberculosis (TB). The prevalence and predictors of LTBI assessed by a high-sensitivity, high-specificity test such as an interferon-gamma release assay (IGRA) has not been thoroughly explored.

Methods

All patients with CKD were prospectively recruited from September 2020 to November 2021 and retrospectively reviewed from December 2020 to November 2021. The prevalence of LTBI was determined using IGRA by CKD stage and dialysis type. Predictors of LTBI were assessed by logistic regression analysis.

Results

In total, 199 patients with CKD were enrolled (102 prospectively, 97 retrospectively). Of these, 173 patients were evaluable (mean age, 53 ± 16 years; 44% male). Ninety-five (55%) patients had ESKD and were maintained on renal replacement therapy. Overall, 39 (22.5%) patients had LTBI with a prevalence of 25.0%, 12.5%, 25.0%, 25.0%, and 24.2% among patients with CKD stage 1, 2, 3a, 3b, and ESKD, respectively (p=0.89). Among patients with ESKD, the prevalence of LTBI was higher in those on hemodialysis than in those on peritoneal dialysis (28.9% vs. 5.3%, p=0.03). In the multivariable analysis of patients with ESKD, drinking alcohol was significantly associated with LTBI (odds ratio, 8.51; 95% confidence interval, 1.24–58.38; p=0.029), and hemodialysis was marginally associated with LTBI (odds ratio, 8.14; 95% confidence interval, 0.95–69.91; p=0.056).

Conclusion

In TB-endemic settings, 20% of patients with CKD and 25% of patients with ESKD may have LTBI. Alcohol consumption and hemodialysis can help to identify high-risk patients with ESKD and potentially screen for LBTI.
Effects of dietary Bacillus amyloliquefaciens on the growth, immune responses, intestinal microbiota composition and disease resistance of yellow catfish, Pelteobagrus fulvidraco
Authors: Xue Mingyang , Wu Yeying , Hong Yizhan , Meng Yan , Xu Chen , Jiang Nan , Li Yiqun , Liu Wenzhi , Fan Yuding , Zhou Yong
Published: November 2022

The influence of dietary probiotic Bacillus amyloliquefaciens on the growth performance, digestive enzyme activity, immune parameters and disease resistance of yellow catfish (Pelteobagrus fulvidraco) was evaluated. Commercial diet (C) or diet containing 106 cfu/g B. amyloliquefaciens (T) was fed for 4 weeks, and final weight (FW), specific growth rate (SGR) and feed conversion ratio (FCR) were improved (p<0.05) in the T group. Dietary B. amyloliquefaciens increased protease and amylase activities in the digestive tract after 2 and 4 weeks, respectively. Respiratory burst (RB), plasma lysozyme (LZM) activity, total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) activity were also elevated (p<0.05). Immune-related genes signal transducer and activator of transcription 1 (STATA-1), immunoglobulin M (IgM) and C-type lectin (CTL) were upregulated (p<0.05), but interleukin-1 β (IL-1β) was not (p >0.05). Intestinal microbiota analysis showed that the community structure was significantly different between the two groups; the relative abundance of Cetobacterium was increased but Plesiomonas was decreased in T. Moreover, challenge tests showed that the resistance of fish fed B. amyloliquefaciens against Aeromonas veronii and Edwardsiella ictaluri was significantly enhanced (p<0.05). In conclusion, dietary supplementation of B. amyloliquefaciens can effectively improve the growth performance, digestive enzyme activity, immune responses, intestinal microbiota composition and disease resistance of yellow catfish.
Identification and characterization of human cytomegalovirus-encoded circular RNAs
Authors: Deng Jingui , Wang Qing , Zhang Jing , Ma Yanping , Qi Ying , Liu Zhongyang , Li Yibo , Ruan Qiang , Huang Yujing
Published: November 2022

Circular RNA (circRNA) exists extensively and plays essential roles in serving as microRNA (miRNA) or protein sponges and protein scaffolding in many organisms. However, the profiles and potential functions of the virus-encoded circRNA, including human cytomegalovirus (HCMV)-encoded circular RNAs, remain unclear. In the present study, HCMV-encoded circRNAs profile in human embryonic lung fibroblasts (HELF) with lytic infection was investigated using RNA deep sequencing and bioinformatics analysis. In total, 629 HCMV-encoded circRNAs were identified with various expression patterns in our results. The full sequences and alternative splicings of circUS12, circUL55, and circUL89 were verified by reverse transcriptase-PCR (RT-PCR) with divergent primers followed and Sanger sequencing. Transcription of circUL89 was validated by Northern blot. The HCMV-encoded circRNA-miRNA network analyses revealed the potential function of HCMV-encoded circRNAs during HCMV infection in HELFs. Collectively, HCMV infection deduced abundant HCMV-associated circRNAs during infection, and the HCMV-encoded circRNAs might play important roles in benefiting HCMV infection.
Clinical outcomes of percutaneous coronary intervention for de novo lesions in small coronary arteries: A systematic review and network meta-analysis
Authors: Ma Wen-Rui , Chandrasekharan Karthik H. , Nai Chang-Sheng , Zhu Yong-Xiang , Iqbal Javaid , Chang Shang , Cheng You-Wei , Wang Xin-Yu , Bourantas Christos V. , Zhang Yao-Jun
Published: November 2022

Background

Percutaneous coronary intervention (PCI) has a well-established role in revascularization for coronary artery disease. We performed network meta-analysis to provide evidence on optimal intervention strategies for de novo lesions in small coronary arteries.

Materials and methods

Enrolled studies were randomized clinical trials that compared different intervention strategies [balloon angioplasty (BA), biolimus-coated balloon (BCB), bare-metal stent (BMS), new-generation drug-eluting stent (New-DES), older generation sirolimus-eluting stent (Old-SES), paclitaxel-coated balloon (PCB), and paclitaxel-eluting stent (PES)] for de novo lesions in small coronary arteries. The primary outcome was major adverse cardiac events (MACE).

Results

A total of 23 randomized clinical trials comparing seven intervention devices were analyzed. In terms of the primary outcome, New-DES was the intervention device with the best efficacy [surface under the cumulative ranking curve (SUCRA), 89.1%; mean rank, 1.7], and the Old-SES [risk ratio (RR), 1.09; 95% confidence interval (CI), 0.45–2.64] and PCB (RR, 1.40; 95% CI, 0.72–2.74) secondary to New-DES, but there was no statistically significant difference between these three intervention devices. All DES and PCB were superior to BMS and BA for MACE in both primary and sensitivity analysis. For secondary outcomes, there was no association between all-cause mortality and myocardial infarction (MI) with any intervention strategy, and additionally, the findings of target lesion revascularization (TLR) were similar to the primary outcomes.

Conclusion

Paclitaxel-coated balloon yielded similar outcomes to New-DES for de novo lesions in small coronary arteries. Therefore, this network meta-analysis may provide potential support for PCB as a feasible, effective, and safe alternative intervention strategy for the revascularization of small coronary arteries.

Systematic review registration

[https://www.crd.york.ac.uk/PROSPERO/#recordDetails], identifier [CRD42022338433].
TELS: Evolution patterns of research keywords from the evidence of PNAS Social Sciences topics
Authors: Liu Bing , Shi Mengfan , Kuang Yi , Jiang Xin
Published: November 2022

By reviewing scientific literature, researchers may obtain a comprehensive understanding of field developments, keeping abreast of the current research status and hotspot shifts. The evolution pattern of keywords is supposed to be an efficient indicator in revealing the shifting and sustainability configuration of scientific concepts, ideas, and research hotspots. Here we take an extensive investigation of the evolution of keywords among all publications in PNAS Social Sciences from 1990 to 2021. Statistical tests show the keyword mention time series always accompanied by the emergence of a log-normal distribution. Additionally, we introduce a novel schema of four patterns (TELS), which are Transient impact type, Explosive impact type, Large impact type, and Small impact type, respectively, to illustrate the evolution of keywords. The TELS schema can be used to capture the whole life circle feature of any proposed keyword, from a pool of candidates. By dividing the entire time into four periods, we also introduce the concept of elite keywords to reveal the temporal feature of social sciences focus. An explicit transition from anthropology research to neuroscience and social problems research can be observed from the evolution diagram. We argue that the proposed method is of general sense and might be applicable to other fields of science.
Diabetes associated with HPV infection in women aged over 50 years: A cross-sectional study from China’s largest academic woman’s hospital
Authors: Yue Chaoyan , Zhang Chunyi , Ying Chunmei , Jiang Hua
Published: November 2022

Background

Metabolic disturbances and immune alterations caused by diabetes are not just bystanders of HPV infection, but the conclusion that diabetes increases the risk of HPV infection requires more clinical epidemiological evidence to confirm. Our aim was to evaluate the association of diabetes with HPV infection risk in female patients aged over 50 years in the cervical clinic.

Methods

We conducted a cross-sectional study of 6402 women aged over 50 years in the cervical clinic between May 2019 and March 2022 from China’s largest academic woman’s hospital. The quantitative-effect relationship between diabetes and HPV infection was observed by dose-response graph. Segmented multivariate logistic regression analysis was conducted to estimate the relative risk of HPV infection in diabetes patients. Multivariable predicted marginal proportions from logistic regression models were used to compute adjusted risk ratios.

Results

There is a nonlinear relationship between HbA1c and the risk of HPV infection. When the HbA1c exceeds 5.7%, there is a saturation effect. After adjustment for confounders, the risk ratio for HPV infection in women with prediabetes was 1.09 (95% CI: 1.00-1.18) compared with women with HbA1c <5.7%, and the risk ratio for HPV infection in women with diabetes was 1.18 (95%). CI: 1.04-1.33). Sensitivity analysis showed that the risk ratio for HPV infection was 1.47 (95% CL: 1.07-1.91) when diabetes was associated with vaginitis. E-value analysis suggested robustness to unmeasured confounding.

Conclusions

Diabetes and prediabetes are at increased risk of coinfection with HPV in female patients aged over 50 years in the cervical clinic.
Optimized RNN-oriented power quality enhancement and THD reduction for micro grid integration of PV system with MLI: Crow Search-based Harris Hawks Optimization concept
Authors: A. Praveena , K. Sathishkumar
Published: November 2022

Grid-connected Photo Voltaic (PV) power systems are becoming increasingly popular in several nations. The goal of achieving maximum power and acceptable power quality in a grid-connected PV power system is considered a major difficulty. Hence, this paper develops an artificial intelligence-based optimization concept for PV system and novel cascaded Multi Level Inverter (MLI) for the grid integration of PV system. The cascaded MLI was designed with fewer power electronic switches and can function at asynchronous voltage sources, making it the most suitable for PV systems. This novel inverter minimizes the THD at the output with the help of enhancing the output voltage level. It also improves the power quality of the system. The micro grid integration of the introduced inverter is controlled by Optimized Recurrent Neural Network (ORNN), where the hidden neurons are tuned by novel hybrid meta heuristic algorithm by merging Crow Search Algorithm (CSA) and Harris Hawks Optimization (HHO) leading to Crow Search-based Harris Hawks Optimization (CS-HHO). The proposed model is designed at several loading conditions and weather conditions. The simulation findings proved the efficiency of the developed system.
Comprehensive risk assessment of non-typhoon rainstorms over the southeastern coastal region of China
Authors: Ye Jinyu , Zhang Rongyan , Lin Guangfa , Zhang Mingfeng , Gao Lu
Published: November 2022

The daily precipitation data (20-20 o’clock) of 66 meteorological stations from 1981 to 2020 were collected. According to the definition of rainstorm day and rainstorm process, 614 non-typhoon rainstorm processes data were obtained after removing the typhoon rainstorm processes data. Combined with the topographic data, the geological disaster points data and the social economic data, this study established an indices system from four aspects: disaster-causing factors, disaster-formative environment, disaster-affected bodies, and disaster prevention and mitigation abilities. Based on the analytic hierarchy process, the entropy method and the correlation coefficient analysis method, the combination weighting was assigned to carry out the non-typhoon rainstorm disaster risk assessment. The results show that the spatial pattern of the comprehensive risk of non-typhoon rainstorm in Fujian Province is completely different from that of typhoon rainstorm in this study area. It shows a gradually increasing trend from the eastern coastal area to the mountainous area in the northwest. The risk areas above middle were observed in the northwestern Fujian and the narrow coastal area of southeastern Fujian. Risk of most of the areas between the two mountain ranges in the middle and northwest of Fujian was relatively lower. The disaster-causing factors were the dominant risk factors of non-typhoon rainstorm. The spatial pattern of non-typhoon rainstorm hazard is obviously affected by the topography of Fujian Province. The comprehensive risk pattern of a specific historical non-typhoon rainstorm case is significantly different from that of the general comprehensive risk of non-typhoon rainstorm disasters. In terms of historical cases, most of the higher-risk and high-risk areas of non-typhoon rainstorm cases were generally small, and were concentrated in northwestern Fujian, but the comprehensive risk pattern of different cases was significantly different.
Landscape of sialylation patterns identify biomarkers for diagnosis and prediction of response to anti-TNF therapy in crohn’s disease
Authors: Ye Chenglin , Zhu Sizhe , Gao Yuan , Huang Yabing
Published: November 2022

Crohn’s disease (CD), a subtype of inflammatory bowel disease (IBD), causes chronic gastrointestinal tract inflammation. Thirty percent of patients do not respond to anti-tumor necrosis factor (TNF) therapy. Sialylation is involved in the pathogenesis of IBD. We aimed to identify potential biomarkers for diagnosing CD and predicting anti-TNF medication outcomes in CD. Three potential biomarkers (SERPINB2, TFPI2, and SLC9B2) were screened using bioinformatics analysis and machine learning based on sialylation-related genes. Moreover, the combined model of SERPINB2, TFPI2, and SLC9B2 showed excellent diagnostic value in both the training and validation cohorts. Importantly, a Sial-score was constructed based on the expression of SERPINB2, TFPI2, and SLC9B2. The Sial-low group showed a lower level of immune infiltration than the Sial-high group. Anti-TNF therapy was effective for 94.4% of patients in the Sial-low group but only 15.8% in the Sial-high group. The Sial-score had an outstanding ability to predict and distinguish between responders and non-responders. Our comprehensive analysis indicates that SERPINB2, TFPI2, and SLC9B2 play essential roles in pathogenesis and anti-TNF therapy resistance in CD. Furthermore, it may provide novel concepts for customizing treatment for individual patients with CD.
Prognostic peripheral blood biomarkers at ICU admission predict COVID-19 clinical outcomes
Authors: Messing Melina , Sekhon Mypinder S. , Hughes Michael R. , Stukas Sophie , Hoiland Ryan L. , Cooper Jennifer , Ahmed Nyra , Hamer Mark S. , Li Yicong , Shin Samuel B. , Tung Lin Wei , Wellington Cheryl L. , Sin Don D. , Leslie Kevin B. , McNagny Kelly M.
Published: November 2022

The COVID-19 pandemic continues to challenge the capacities of hospital ICUs which currently lack the ability to identify prospectively those patients who may require extended management. In this study of 90 ICU COVID-19 patients, we evaluated serum levels of four cytokines (IL-1β, IL-6, IL-10 and TNFα) as well as standard clinical and laboratory measurements. On 42 of these patients (binned into Initial and Replication Cohorts), we further performed CyTOF-based deep immunophenotyping of peripheral blood mononuclear cells with a panel of 38 antibodies. All measurements and patient samples were taken at time of ICU admission and retrospectively linked to patient clinical outcomes through statistical approaches. These analyses resulted in the definition of a new measure of patient clinical outcome: patients who will recover after short ICU stays (< 6 days) and those who will subsequently die or recover after long ICU stays (≥6 days). Based on these clinical outcome categories, we identified blood prognostic biomarkers that, at time of ICU admission, prospectively distinguish, with 91% sensitivity and 91% specificity (positive likelihood ratio 10.1), patients in the two clinical outcome groups. This is achieved through a tiered evaluation of serum IL-10 and targeted immunophenotyping of monocyte subsets, specifically, CD11clow classical monocytes. Both immune biomarkers were consistently elevated ( ≥15 pg/ml and ≥2.7 x107/L for serum IL-10 and CD11clow classical monocytes, respectively) in those patients who will subsequently die or recover after long ICU stays. This highly sensitive and specific prognostic test could prove useful in guiding clinical resource allocation.
Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and pro-inflammatory cytokines
Authors: Mulder Patrick P.G. , Vlig Marcel , Fasse Esther , Stoop Matthea M. , Pijpe Anouk , van Zuijlen Paul P.M. , Joosten Irma , Boekema Bouke K.H.L. , Koenen Hans J.P.M.
Published: November 2022

The systemic and local immune response in burn patients is often extreme and derailed. As excessive inflammation can damage healthy tissues and slow down the healing process, modulation of inflammatory responses could limit complications and improve recovery. Due to its complexity, more detailed information on the immune effects of thermal injury is needed to improve patient outcomes. We therefore characterized and quantified subsets of immune cells and mediators present in human burn wound tissue (eschar), sampled at various time points. This study shows that after burn injury, the number of immune cells were persistently increased, unlike the normal wound healing process. There was an immediate, strong increase in neutrophils and a moderate increase in monocytes/macrophages and lymphocytes, especially in the second and third week post burn. The percentage of classical (CD14highCD16-) monocytes/macrophages demonstrated a steady decrease over time, whereas the proportion of intermediate (CD14highCD16+) monocytes/macrophages slowly increased. The absolute numbers of T cells, NK cells and B cells increased up to week 3, while the fraction of γδ T cells was increased only in week 1. Secretome profiling revealed high levels of chemokines and an overall pro-inflammatory cytokine milieu in burn tissue. The local burn immune response shows similarities to the systemic immune reaction, but differs in neutrophil maturity and lymphocyte composition. Altogether, the neutrophil surges, high levels of pro-inflammatory cytokines and limited immunosuppression might be key factors that prolong the inflammation phase and delay the wound healing process in burns.