bluuebunny/crossref_metadata_2025 huggingface dataset:
Yogic Practices as a Complementary Approach to Physical Fitness: An Intervention Study
Authors: Pramanik Tarak Nath , Rahaman Aminur , Saha Gopal Chandra , Roy Anupam , Pradhan Punam
Published: January 2025

Background. Yoga is an ancient practice that has gained attention for its potential benefits on muscular strength and endurance, flexibility, power, agility, balance, reaction time, and body mass index (BMI), making it an effective complementary approach for improving overall health and physical fitness.
Objectives. This study aimed to evaluate the effects of a six-week yogic regimen on overall health and physical fitness in male university students.
Materials and Methods. Forty male students, aged 18 to 24, from the University of Delhi were randomly assigned to an experimental group or a control group, each comprising 20 participants. The experimental group underwent a six-week yogic intervention, including asanas, pranayama, and meditation, conducted daily under the guidance of certified instructors. The control group continued their usual daily routines. Pre- and post-intervention measurements were conducted to assess muscular strength, muscular endurance, flexibility, power, agility, balance, reaction time, and BMI. Data analysis involved both descriptive statistics and inferential statistics (paired and independent sample t-tests) using SPSS software (version 25), with a significance level set at α = 0.05.
Results. The experimental group showed considerable improvements in muscular strength, muscular endurance, flexibility, power, agility, balance, reaction time, and BMI (p < .005). In contrast, the control group did not exhibit any notable changes in these parameters. Pre-test comparisons revealed no substantial differences between the experimental and control groups across any variables. However, post-test comparisons between the groups demonstrated significant differences in several key areas: muscular strength, muscular endurance, balance, and reaction time (p < .005). Conversely, no major differences were observed in flexibility, power, agility, or BMI (p > .005).
Conclusions. A six-week yogic intervention effectively enhances muscular strength, muscular endurance, flexibility, power, agility, balance, and reaction time, while reducing BMI in university students. Incorporating yoga into physical education and individualized training programs has the potential to significantly enhance fitness outcomes across diverse populations.
Promoting Inclusion and Well-Being Through Inclusive Physical Education and Parasports: an Approach for Adolescents with Motor Impairment
Authors: Ben Rakaa Omar , Bassiri Mustapha , Lotfi Said
Published: January 2025

Objectives. This study aimed to examine the impact of inclusion students with motor impairment (MI) into adapted physical education (APE) and school para-athletics on their feeling of pedagogical and school inclusion, as well as on their psychological well-being and self-esteem.
Materials and Methods. The study involved 96 pupils having motor impairment, aged 16.79 ± 0.87, enrolled in public schools in Morocco. The pupils were divided into three groups according to the para-athletics classification: 30 % (family of 30), 40 % (families of 40) and 30 % (family of 50). The participants were randomly assigned into three groups: a control group with no specific programme, a group following an APE programme (24 sessions), and a third group with APE and additional para-athletics sessions (24 sessions), including competitions for three months. The assessments were carried out before and after the intervention. The scales were employed to gauge self-esteem, psychological well-being, as well as feeling of pedagogical and schooling inclusion.
Results. The findings indicate that students who engaged in both the APE and para-athletics programmes exhibited enhancements in their feeling of pedagogical and schooling inclusion, psychological well-being, and self-esteem, when compared to the control group. The group that participated in both APE and para-athletics demonstrated the most significant progress in this study.
Conclusions. The findings suggest that the integration of adapted physical education and inclusive sports, including para-athletics, into school curricula in a systematic manner represents a pivotal element in promoting inclusion, well-being and self-esteem among students with motor impairments.
Exploratory Factor Analysis on the Talent Development Environment Questionnaire (TDEQ-5) for Basketball in Indonesia
Authors: Putro Kukuh Hardopo , Suharjana Suharjana , Marhaendro Agus Susworo Dwi , Fauzi Fauzi , Wicaksono Danang , Irianto Subagyo , Prabowo Trisnar Adi
Published: January 2025

Objectives. This study aimed to adapt and measure the level of validity and reliability of the Talent Development Environment Questionnaire (TDEQ-5) for basketball in Indonesia. 
Materials and methods. A quantitative approach was employed, using the Exploratory Factor Analysis (EFA) method and Cronbach’s Alpha test to determine the reliability of the instrument. The sample comprised 420 basketball athletes (212 men, 208 women) from the Developmental Basketball League, distributed across eight provinces, which were divided into nine major cities in Indonesia. The characteristics of the sample (mean ± SD) were as follows: aged 15 to 18 (17.8 ± 7.2 years old), training experience was 4 to 8 years (5.3 ± 8.9 years), and participating in competitions experience twice to four times a year. The analysis of this study is based on each factor: Long-term development (LTD), Alignment of expectations (AOE), Communication (COM), Holistic quality preparation (HQP), and Social network (SN). 
Results. The results showed that KMO-MSA was p > 0.5, and Bartlett’s Test of Sphericity was p < 0.05. Furthermore, Anti-image Correlation, Communalities, and Pattern Matrix Test also exhibited p > 0.5. The Cronbach’s Alpha value was found to be 0.924. 
Conclusions. These findings indicate that the TDEQ-5 is a reliable and valid tool for assessing the talent development environment of basketball athletes, especially in Indonesia. However, further development of this instrument is recommended to be adapted to the sports culture in Indonesia and to ensure a more comprehensive and scientific evaluation of talent coaching in basketball.
NEW MANAGEMENT PRINCIPLES: INTERACTION BETWEEN THE MAIN ACTORS OF THE CITY
Authors:   University of Tyumen, Kostko Natalya , Pecherkina Irina ,   University of Tyumen, Popkova Alena ,   Tyumen Industrial university
Published: January 2025

The article analyzes the willingness to accept the polysubjectivity of city development management by all its participants. The answer to the research question: do representatives of municipal authorities, businesses, NGOs see the population as a subject of urban development management, demonstrates the difference in the approaches between the main actors. The essential characteristic of the concept of "citizen subjectivity" is substantiated taking into account the analysis of two concepts of urban development: new municipalism and smart city. The paper draws on the results of a mass survey of residents of six cities of the Tyumen region (the total sample size is 2,860 people) and interviews with experts (65 expert interviews with representatives of government, business, non-profit organizations of thesame cities). The findings of the study demonstrate that the imperfection of the existing horizontal links presents an obstacle to the embodiment of the subjective role of citizensin the processes of urban development. The unequ al or uneven opportunities available to the actors of city management (in terms of access to information, budgetaryresources, infrastructure, services, etc.) often become a significant barrier to constructive interaction. The principal challenge in accepting the subjectivity of residents is the lack of synchronization between the development goals and the strategies for achieving them collectively by the actors involved in urban development management. It is argued that constructive interaction is possible when common, shared values, motives, and competencies of the significant actors of modern city management – namely, the authorities, businesses, and the urban population – are formed in the urban space.
Оценка эффективности социальной технологии с точки зрения преимуществ и затрат
Authors: Рождественская Елена , Абрамов Роман , Сабля Алексей
Published: January 2025

Статья посвящена оценке эффективности социальных технологий. Мы фокусируем внимание на балансе затрат и преимуществ при осуществлении социальной интервенции в проблемные семьи с детьми. В практике оценки редко рассматриваются издержи реализации таких программ. Исследование основано на клиенто-­ориентированной концепции модели Шрайнера, которая включает показатели общей стоимости услуг, стоимости, преимуществ и чистой выгоды для клиента, количества клиентов, объема предоставляемых услуг и времени оказания услуги. Модифицированная версия модели, дополненная оценкой влияния качества управления на эффективность услуги, была эмпирически реализована через качественную методологию, а именно интервьюирование сотрудников семейных центров. Результаты исследования показали, что стоимость случая включает не только зарплату специалистов, но и благотворительные средства, гранты НКО, выплаты управ, частные и даже личные деньги сотрудников. Хотя услуги для клиентов бесплатны, они иногда несут небольшие личные затраты (транспорт, оформление документов и справок) и не материальные издержки (эмоции стыда и потеря репутации). Преимущества для клиента очевидны и включают профессиональную помощь команды, которая восполняет навыки и ресурсы, предоставляет консультации и помощь, улучшает эмоциональный фон семьи, способствует росту доверия, самоуважения и самоэффективности. Выявлен значительный разрыв между нормативным стандартом по количеству опекаемых детей из проблемных семей и фактически обслуживаемым количеством. Менеджериальная оценка демонстрирует необходимость выделения службы выявления новых случаев в отдельный функционал и подчеркивает амбивалентную реакцию специалистов на эту политику, рациональность которой не всегда принимается.
GenomeTrakr WGS Protocol Collection and Workflow for MiSeq v2
Authors: Pfefer Tina , Haendiges Julie , Balkey Maria , Hope Bias Candace , Timme Ruth
Published: January 2025

Here we have created a collection of all the protocols used for WGS using the MiSeq, in order, from sample extraction to NCBI submission. This collection has three sections: Section 1: WGS Wet lab workflow for Illumina MiSeq Section 2: Dry lab workflow for sequence QC and NCBI submission - Direct Submission Section 3: Dry lab workflow for sequence QC and NCBI submission - PulseNet labs Version history: V4: Links to protocols updated with latest version, and Step 13 - Removed protocol "Populating NCBI template for submissions using BioNumerics", and replaced with protocol "Populating metadata templates for NCBI submissions using PulseNet 2.0" V3: Links to protocols updated with latest version, Added new protocol: DNA Extraction from Inoculated Broth for WGS using the Maxwell RSC Cultured Cells DNA Kit, Added new protocol: Querying for Bacterial Pathogen Genomic Data at NCBI.
U-PLEX® Metabolic Group 1 (mouse) Multiplex Assays v1
Authors: White Alexandria , Chang Jianjun
Published: January 2025

The U-PLEX platform allows the creation of custom multiplex assays for any combination of analytes in the same Group. This product insert is for U-PLEX Combos and multiplex assays that contain any number of the 58 assays in the U-PLEX Metabolic Group 1 (mouse). Using open spots, custom combinations can include R-PLEX® Antibody Sets or your antibodies for other analytes. Representative data for each U-PLEX assay is presented in the product-specific datasheets available at the www.mesoscale.com® website. The performance of MSD assays may vary when tested in combination. The data presented in the datasheets do not represent the product specifications
Human Tissue Procurement from Atlanto-Axial Fusion Surgery v1
Authors: P Hofstetter Christoph , Tran Nguyen , Payne Cathryn
Published: January 2025

Purpose Describe the human tissue removal, preservation, storage, and transportation procedures during tissue procurement from patients undergoing C1-2 arthrodesis (surgical immobilization of a joint by fusion of the adjacent bones). Responsibility The Human Tissue Procurement and Processing Core at the University of Washington and the University of Texas at Dallas are responsible for maintaining this protocol, ensuring it is updated and controlled, and ensuring that users receive proper training prior to its implementation. Definitions and Abbreviations DRG = dorsal root ganglia OR = operating room PPE = personal protective equipment UTD = The University of Texas at Dallas UW = University of Washington Tissue Recovery Sites Local hospitals Tissue Recovery Team UW Surgical Staff UW Research Coordinator UW Scrub Nurse
Plasmid Cloning - PureLink Kit v1
Authors: Flanagan Ty
Published: January 2025

This protocol is for plasmid cloning using E. coli and the PureLink Quick Plasmid Miniprep Kit. See the Plasmid Ext - PureLink Quick Plasmid Miniprep Kit Protocol.pdf on the Goolge Drive.
METHODOLOGICAL ASPECTS AND RESULTS OF DETERMINING THE TECHNICALLY POSSIBLE HYDROPOWER POTENTIAL OF UKRAINIAN RIVERS (ON THE EXAMPLE OF THE DNIPRO RIVER BASIN)
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, OBODOVSKIY Oleksandr , DANKO Kostiantyn ,   Ukrainian Hydrometeorological Institute, Kyiv, Ukraine, POCHAIEVETS Olena ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, KOROHODA Nataliia ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, GREBIN Vasyl ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: January 2025

Background. Diversification of electricity generation sources is gaining considerable attention in Ukraine today. This is especially true when the russian aggressors put out of commission the power generating capacities of thermal power plants and large hydroelectric power plants. In this context, the use of alternative (renewable) energy sources, in particular small hydropower, becomes important. That is why it is important to study the technically possible hydropower potential of rivers.

Methods. The rationale for and the size of the technically feasible hydropower potential of rivers can be determined from the general scheme for determining the potential for rivers in Ukraine that we have proposed. For this purpose, an expert assessment of the main risks that may reduce the overall hydropower production was carried out.

Results. It has been established that the largest percentage of losses of technically possible potential, relative to the total hydropower potential (THP), is inherent in the basins of the Pripyat, Stokhid and Samara rivers and ranges from 48–58.5 %. The slopes of river channels and waterlogging of their catchments play a key role here. The lowest rates of these losses are typical of such rivers as the Supiy, Irkliy, Stvyha and Uzh, and vary from 23 to 25 %. The priority here is losses caused by waterlogging and reclamation of floodplains.

Conclusions. Taking into account all potential losses and risks, 226087 kW (39 %) of the total hydropower potential of the studied rivers can be considered suitable for use.
SEA-LAND SEGMENTATION MODELS IN DEEP LEARNING FROM REMOTE SENSING DATA
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, OKHRIMCHUK Roman , DEMIDOV Vsevolod ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, SLIUSAR Kateryna ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: January 2025

Background. Coastline changes can have a significant impact on coastal landscape, ecosystems and communities. Therefore, monitoring of such a highly dynamic system as sea-land is an urgent task that can be solved both by traditional methods and by using depth learning techniques to improve the efficiency of processing such as class of tasks. The object of the authors' research is the coastline along the coast of the western part of the Crimean Peninsula, the study of which by traditional methods has become impossible due to the temporary occupation of the Crimean Peninsula since 2014. The paper considers the main coastal indicators and methods of coastline digitization. The main types of satellite images as well as their combinations are compared for effective utilization of the shoreline mapping task. Many methods are used to recognize and extract shorelines in satellite images, which are generally divided into three groups: indexing, edge detection and classification methods.

Methods. Authors compared the main depth learning models that can be used to efficiently recognize the coastline and its boundaries in satellite images, which include ISODATA (Iterative Self-Organizing Data Analysis Technique), Maximum Likelihood Estimation (MLE), Random Forest (RF), K-Nearest Neighbors (KNN), Support Vector Machine (SVM), U-Net, and Segment Anything Model (SAM).

Results. The outlines of the Crimean Peninsula coastline were obtained on the basis of PlanetScope images using ISODATA, MLE, RF, KNN, SVM, U-Net, SAM methods. The obtained images and their performance were compared. The study included the development of a Python code to automatically generate reports including information on five evaluation metrics, such as accuracy (98.96), recall (99.45), precision (97.27), F1-score (98.34), and IoU (96.74), which facilitated the evaluation of different approaches and methods.

Conclusions. The comparative analysis highlights the advantage of the U-Net model for shoreline extraction from remotely sensed images. U-Net consistently provides the most accurate and detailed segmentation in different scenarios, demonstrating robustness and accuracy.
Kavramdan Sınıfa: Yapay Zekânın Keşfi ve Eğitime Yansımaları
Authors: Deniz Serpil , Bağçeçi Birsen
Published: January 2025

Bu araştırma yapay zekânın doğuşu, tarihsel gelişimi, güncel durumu ve eğitimdeki mevcut etkileri üzerinde kapsamlı bir inceleme sunmaktadır. Geleneksel alanyazın taraması benimsenerek yürütülen bu çalışmada yapay zeka türleri ve bunların eğitim sektöründeki uygulama alanlarının mevcut literatür kapsamında titizlikle incelendiği ve eleştirel bir okumasının yapılmış, çağdaş bilimsel çalışmalardan ve devam eden tartışmalardan yararlanılarak eğitimde yapay zekâ kullanımının olumlu ve olumsuz getirileri karşılaştırılmıştır. Uluslararası alanda yapay zekâ uygulamalarının ve sonuçlarının eğitimin gelişimindeki rolüne genel bir bakış açısı sunmak için geniş bir akademik tarama yapılarak elde edilen bulguların sentezi yapılmıştır. Yapay zekânın öğrenme deneyimlerini geliştirmede ne tür bir devrim yaratabileceği, eğitim öğretim ortamlarını bireysel ihtiyaçlara göre nasıl uyarlayabileceği ve kurumsal görevleri nasıl kolaylaştırabileceği vurgulanırken, diğer bir açıdan etik ihlaller, veri gizliliği ve potansiyel risklerle ilgili endişeleri de gündeme getirmektedir. Ayrıca bu makalede eğitimde yapay zekâ çalışmalarındaki mevcut sonuçlar tanımlanmakta ve gelecek çalışmalar için aydınlatıcı öneriler sunulmaktadır. Ayrıntılı ve eleştirel bir bakış açısı sunan bu çalışmada yapay zekânın ilk günlerinden son gelişmelerine kadar, eğitimdeki dönüştürücü potansiyelinden. yaratabileceği zorlukları hafifletme stratejileri hakkında alınabilecek önlemlere varan önemli çıkarımlar sunulmuştur.

This research comprehensively examines the emergence, historical development, current status, and current effects of artificial intelligence on education. In this study, which is conducted by adopting a traditional literature review, types of artificial intelligence and their application areas in the education sector are meticulously examined and critically read within the scope of the existing literature, and the positive and negative outcomes of the use of artificial intelligence in education are compared by making use of contemporary scientific studies and ongoing debates. A broad academic review was conducted to provide an overview of the role of artificial intelligence applications and results in developing education in the international arena, and the findings were synthesised. While emphasising how AI can revolutionise the development of learning experiences, tailor educational and training environments to individual needs and facilitate institutional tasks, it also raises concerns about ethical violations, data privacy and potential risks. In addition, this article describes the current results of artificial intelligence studies in education and provides enlightening suggestions for future studies. Offering a detailed and critical perspective, this study presents important implications from the early days of artificial intelligence to its recent developments, from its transformative potential in education to precautions that can be taken about strategies to mitigate the challenges it may create.
Prospects for using a proteomic approach to evaluate the effectiveness of implantation of embryos transferred in an IVF cycle
Authors: Zementova Maria S. , Selkov Sergey A. , Dmitry Dmitry I.
Published: January 2025

This review presents non-invasive ways to evaluate the implantation potential of embryos that have entered the IVF cycle. A morphological approach to assessing the quality of embryos used in clinical practice is described. In addition, non-invasive approaches such as cell-free DNA analysis in culture medium, assessment of morphokinetic changes of individual embryos using artificial intelligence models, analysis of oxygen consumption by individual embryos, and the proteomic approach are considered in the literature as additions to the existing embryo quality assessment system. The focus of this article is on the identification of protein molecules in spent culture media of cleavage embryos as the most promising and poorly studied approach. The diagnostic significance of human chorionic gonadotropin and its isoforms, tumor necrosis factor alpha, interleukin-6, -8, -1β, human leukocyte antigens-G, stem cell factor, interferon-α, chemokines (CCL15, CCL27, CXCL12), platelet endothelial cell adhesion molecule 1, tissue inhibitors of metalloproteinase 4, E-selectin, von Willebrand factor and other compounds as biomarkers of embryo implantation potential is described. The analysis of these proteins in the spent culture media of embryos can complement the morphological assessment of embryo quality when making decisions on choosing an embryo for transfer.
Prognostic significance of the microbial factor in patients with miscarriage in early pregnancy registration
Authors: Beliaeva Natalia R. , Budilovskaya Olga V. , Khusnutdinova Tatiana А. , Krysanova Anna А. , Shalepo Kira V. , Savicheva Alevtina M. , Tapilskaya Natalya I. , Kogan Igor Yu.
Published: January 2025

Background: The role of the microbial factor in the genesis of early miscarriages (up to 10 weeks of pregnancy) has not been established. However, disruption of the vaginal microbiota may be associated with the occurrence of late miscarriage.
Aim: The aim of this study was to evaluate the frequency of early and late miscarriages and to determine the prognostic significance of the microbial factor in early pregnancy registration.
Materials and methods: This study involved 113 pregnant women registered before 10 weeks of gestation, who were divided into two study groups. Group I consisted of 22 women whose pregnancy ended in miscarriage before 22 weeks (subgroup IA of 19 patients with early miscarriage and subgroup IB of three patients with late miscarriage). Group II comprised 91 women whose pregnancy ended in term delivery. Vaginal microflora was investigated using microscopic and molecular biological methods.
Results: The frequency of miscarriages among the examined women was 20.4%. The proportion of early miscarriages was 86.4% and late miscarriages 13.6%. In Group I, the number of births in the anamnesis was higher than in Group II. The average rate of births per woman was 2.0 in Group I and 0.9 in Group II (p = 0.037); the number of previous pregnancy loss per woman was 1.2 in Group I and 0.5 in Group II (p = 0.019). Lactobacilli were detected in the vaginal biotope of all pregnant women. Lactobacillus iners and Lactobacillus crispatus were the most frequently occurring species. In subgroup IA and Group II, opportunistic pathogenic microorganisms were detected with equal frequency at first pregnancy examination and did not alter the existing vaginal microbiocenosis. In subgroup IB, Gardnerella vaginalis, Atopobium vaginae, Enterobacteriaceae, Staphylococcus spp., Streptococcus spp., Mycoplasma hominis or Ureaplasma spp. were detected simultaneously in early pregnancy, with Lactobacillus cristatus predominating.
Conclusions: The proportion of early miscarriages was six times higher than that of late miscarriages. We have not found an association between the quantitative and qualitative compositions of vaginal microorganisms in the first trimester of pregnancy and early miscarriages. The microbial factor was established to be important in late miscarriages. Further studies are needed to assess the prognosis of late miscarriages at the time of pregnancy registration.
Experimental model of non-alcoholic fatty liver disease in pregnant rats to evaluate the effectiveness of therapy
Authors: Mozgovaia Elena V. , Kryshnia Marina A. , Blazhenko Alexandra А. , Nuzhnova Alina А. , Tolibova Gulrukhsor , Tral Tatyana G. , Toumasova Janna N. , Korenevsky Andrey V. , Zalozniaia Irina V. , Ganzhina Victoria S. , Bespalova Olesya N.
Published: January 2025

Background: The growing incidence of non-alcoholic fatty liver disease in the population contributes to the development of obstetric complications during pregnancy and demands searching effective methods of hepatoprotective therapy.
Aim: The aim of this study was to evaluate the efficacy of therapy for non-alcoholic fatty liver disease in an experimental model in pregnant rats.
Materials and methods: this experimental study was carried out on 19 female Wistar rats weighing 250–300 g, obtained from the laboratory animal nursery of SMK Stezar Ltd. (Vladimir, Russia). Using a high-fat diet, non-alcoholic fatty liver disease was simulated in the study groups as follows. Group 1 (n = 7) consisted of non-pregnant rats, group 2 comprised pregnant rats without therapy (n = 6), and group 3 included pregnant rats and intraperitoneal administration of 12 mg of the low-molecular sugar preparation from day 16 to day 20 of gestation (n = 6). During the experiment, the body weight of female rats was measured weekly. After the experiment was completed, we evaluated the blood serum levels of aspartate aminotransferase, alanine aminotransferase, ferritin, triglycerides, total cholesterol, total bilirubin, urea, total alkaline phosphatase, bile acids, glucose, C-reactive protein, cholinesterase, and malondialdehyde, as well as catalase activity. Histological examination of the rat liver was carried out using the standard method with hematoxylin and eosin staining.
Results: This study showed that high-fat diet caused oxidative stress manifested by decreased the blood catalase level and increased malonovodialdehyde in both pregnant and non-pregnant females; the blood bile acids level also increased. In pregnant rats with non-alcoholic fatty liver disease, the serum C-reactive protein and total alkaline phosphatase levels increased, the cholinesterase level decreased, and the catalase activity decreased even more. In the study group using the low-molecular sugar preparation, biochemical parameters in non-alcoholic fatty liver disease improved, probably due to the effect on lipogenesis and oxidative stress in the liver. The histological pattern was characterized by the impaired structural characteristics of hepatocytes and the circulatory bed. With the use of the low-molecular-weight sugar preparation, we noted a tendency to restore the structure of the hepatic beam area and a decrease in the manifestations of steatosis.
Conclusions: The use of the low-molecular-weight sugar preparation in the treatment of non-alcoholic fatty liver disease improves biochemical blood parameters and tends to restore the histological structure of the liver.
The new method for premature ovarian insufficiency treatment based on the effect of omaveloxolone (RTA 408) on the mitochondrial function of granulosa cells
Authors: Zakuraeva Karina А. , Yarmolinskaya Maria I. , Vinokurov Andrey Yu. , Pogonyalova Marina Yu.
Published: January 2025

Background: Premature ovarian insufficiency is a syndrome characterized by secondary hypergonadotropic ovarian insufficiency and a decrease in the ovarian function in women under 40 years of age, thereby leading to impaired reproductive function, metabolic changes, and a decrease in the quality of life. Increased production of reactive oxygen species inhibits the mitochondrial respiration chain and leads to mitochondrial dysfunction and oxidative stress, which are considered as the triggers of premature ovarian insufficiency. To date, there is no universal method of premature ovarian insufficiency prevention, and accepted treatment methods can only compensate for clinical symptoms, but not restore the lost ovarian reserve.
Aim: The aim of this study was to develop a new method of premature ovarian insufficiency treatment based on an experimental ovarian granulosa cell model using omaveloxolone (RTA 408).
Materials and methods: The cell model of premature ovarian insufficiency used in the study was realized according to the Patent RU 2 815 539 C1, 2023 (by M.I. Yarmolinskaya, K.A. Zakuraeva, A.Yu. Vinokurov, M.Yu. Pogonyalova). Ovarian granulosa cells isolated from three-month Wistar rats were subcultivated five times with subsequent seeding on coverslips. The cells on the coverslips were divided into three groups (three coverslip in each group). In Group 1 (comparison group — premature ovarian insufficiency model without treatment), cells were treated with cyclophosphamide (0.1 mg/ml) during 6 h. In Group 2 (main group — premature ovarian insufficiency model with experimental treatment) cells were pretreated with RTA 408 (2 µl/ml) during 1 h with subsequent addition of cyclophosphamide (0.1 mg/ml) and cultivation during 6 h. And in Group 3 (control group), cells were added no substances.
Results: Compared to Groups 2 and 3, the use of omaveloxolone (RTA 408) led to an increase in reduced glutathione level and a decrease in reactive oxygen species production rate, which indicates the antioxidant and anti-inflammatory effects of the drug and may be considered as a perspective strategy of premature ovarian insufficiency treatment. The claimed method expands the number of premature ovarian insufficiency treatment strategies and avoids the use of hormonal medications and surgical procedures, thus reducing the risk of side effects and complications associated with their use.
Leveraging Submarine DAS Arrays for Offshore Earthquake Early Warning: A Case Study in Monterey Bay, California
Authors: Gou Yuancong , Allen Richard M. , Zhu Weiqiang , Taira Taka’aki , Chen Li-Wei
Published: January 2025

Detecting offshore earthquakes in real time is challenging for traditional land-based seismic networks due to insufficient station coverage. Application of distributed acoustic sensing (DAS) to submarine cables has the potential to extend the reach of seismic networks and thereby improve real-time earthquake detection and earthquake early warning (EEW). We present a complete workflow of a modified point-source EEW algorithm, which includes a machine-learning-based model for P- and S-wave phase picking, a grid-search location method, and a locally calibrated empirical magnitude estimation equation. Examples are shown with offshore earthquakes from the SeaFOAM DAS project using a 52-km-long submarine cable in Monterey Bay, California, demonstrating the robustness of the proposed workflow. When comparing to the current onshore network, we can expect up to 6 s additional warning time for earthquakes in the offshore San Gregorio fault zone, representing a substantial improvement to the existing ShakeAlert EEW system.
Imaginary or Real Necessity of War with Ottoman Empire per 1877–1878? (on materials of sources of a personal origin)
Authors:   State Archive of the Saratov region, Kochukov S. A.
Published: January 2025

Clause is devoted to analysis of the various points of view on necessity of war with Turkey, and also critical estimations of Russian army and readness of Russia for operations. The author consides positions of various representatives of Russian society – historians D.I. Ilovajskogo, M.P. Dragomanova; the representative of high society of prince V.P. Meshcherskogo.
American Missionaries in the Osmanic Empire in the XIX Century and Beginning of XX Century
Authors:   Volga region Cooperative Institute (branch) of the Russian University of Cooperation, Zimina N. G.
Published: January 2025

The policy of proselitism in the Ottoman Empire in the nineteenth and at the beginning of the twentieth centuries in the article. The activity of the American Protestant missionaries is shown among the Orthodox Christians and Armenians.
Holidays and Everyday Life of «the Great Mogul» through the Eyes of the First English Travellers (late XVI – early XVII Centurie)
Authors:   Saratov State University, Koroleva О. V.
Published: January 2025

This article analyse the portrayal of Eastern ruler as ‘another’ culture by English travellers. The endeavour was to show what were early modern English perceptions of a way of life of the Emperor Jahangir. During the first period of English commercial presence in India, the figuration of a culture was represented by its ruler. This practice homogenized and simplified a culture, making it more easily knowable and thus inferior. In the English travel writing of East, a ruler quickly becomes the focus of the civilized/barbaric binary. The Jahangir, figured in this way as «the Great Mogul», becomes the subject of discourses about exoticism, cruelty, and sensuality that characterize Eastern ruler (supreme or local), and his power were depicted was despotic if not tyrannical. That allowed Europeans to declare their superiority over the most powerful and impressive non-European civilizations during early modern time.
Analisys of the socio-economic impact of the energy crisis
Authors:   Universidad de Deusto, Larrea Basterra Macarena , Badajoz Lopez Arkaitz
Published: January 2025

Energy crises can have essential repercussions in various areas, such as society, the economy, national security and the environment. Shortages of energy resources can lead to higher
prices and increased competition for energy resources, which can negatively affect economic growth and business competitiveness. In addition, an energy crisis can also lead to outages in
the supply of electricity or other energy sources and interruptions in essential services, which can harm national security and the population's well-being. Similarly, higher energy prices,
such as gas in this case, can result in higher coal consumption with a corresponding impact on GHG emissions. This report develops a framework for analyzing the socioeconomic impact of
an energy crisis based on a review of the literature on the subject. This framework is then applied further to explore the effects of the recent energy crisis in Spain.
De los Sistemas de Medición del Desempeño a los Sistema de Gestión del Desempeño en la administración pública local: ¿Colombia realizó la transición?
Authors: Ceballos-García Grey Yuliet , Agudelo Luis Fernando , Pinzón-Villa Mariana
Published: January 2025

Este artículo examina la transición de los Gobiernos locales en Colombia desde la medición del desempeño hacia la gestión del desempeño, como instrumento de la gestión de relaciones intergubernamentales. La implementación de esquemas de seguimiento y evaluación basados en índices, para categorizar y medir el desempeño de los municipios, fue una expresión de las reformas gerencialistas y la profundización de la descentralización desde la década de 1980. Estos cambios se centraron en la medición, en primer lugar, y en el control de la sostenibilidad fiscal, después. Tras más de dos décadas de implementación, se ha avanzado en la medición de capacidades fiscales y administrativas locales. Sin embargo, aún queda mucho trabajo por hacer, como comprender las capacidades coercitivas y lograr procesos de acompañamiento que viabilicen una mejora sostenible de la gestión y una provisión más homogénea de bienes públicos en el territorio.
RACISMO, GUERRA ÀS DROGAS E A PEC 45/2023: o avanço de estratégias de destruição
Authors: Prudencio Juliana Lobo , Passos Rachel Gouveia
Published: January 2025

O presente artigo convoca à reflexão acerca da guerra às drogas como artifício racista para a contenção de corpos negros no Brasil, realizando uma aproximação analítica com a PEC 45/2023, a chamada “PEC drogas”, que vem convocando reflexões acerca da ação estatal no ato de aprisionar. Para tal, utiliza, como recurso metodológico, a revisão de literatura e análise documental. Observa os caminhos da guerra às drogas através da mão opressora estatal e do descaso governamental, seja pela condenação por tráfico de drogas, pelo sucateamento da política de saúde mental, álcool e outras drogas ou pela aprovação da PEC 45/2023 que transforma o usuário de drogas em criminoso, escancarando a postura racista de um Estado que, pela opressão ao tráfico de drogas, mata cotidianamente pessoas negras e pobres.
ASSISTÊNCIA SOCIAL E TOMADA DE CRÉDITO: ameaça à proteção social estatal
Authors: Oliveira Tâmara Feitosa , Alencar Júnior Osmar Gomes de
Published: January 2025

Neste artigo o objetivo é problematizar a repercussão da financeirização da assistência social na proteção social. Para tanto, realiza revisão bibliográfica das categorias: proteção social, capital portador de juros, capital fictício e assistência social. Ademais, recorre a fontes secundárias sobre o financiamento da assistência social e da seguridade social. Concluique a Assistência Social tem sido porta de entrada das famílias de baixa renda no processo de acumulação financeira, contribuindo para o fortalecimento do capitalismo monopolista, marcado pelas finanças e que fragiliza a proteção social.
EDUCAÇÃO INCLUSIVA NO BRASIL, ANGOLA E MOÇAMBIQUE
Authors: Renk Valquiria Elita , Guebert Mirian
Published: January 2025

Este estudo visa identificar como Angola, Moçambique e Brasil adotam as políticas públicas educacionais com vistas à promoção da inclusão escolar, aborda as políticas educacionais inclusivas no recorte temporal de 1975 a 2020. É um estudo comparativo com análise dos documentos oficiais sobre educação de cada país, para identificar se os documentos contemplam a temática de educação inclusiva. Utiliza a metodologia baseada no estudo documental, com a análise interpretativa e na perspectiva interdisciplinar da educação como um direito humano, subsidiado por Silva(2014) Silva(2015), Garcia(2017) Visentini (2012). Os resultados apontam para a articulação das recomendações internacionais para a estruturação das políticas públicas educacionais nos países estudados para a desenvolvimento de uma sociedade inclusiva e menos desigual, tendo a educação como um direito.
POLÍTICA EDUCACIONAL E GOVERNO BOLSONARO: “Conta pra Mim”, Escolas Cívico-Militares e “Future-se”
Authors: Martins Thales Eduardo de Oliveira , Duarte Janaína Lopes do Nascimento
Published: January 2025

Este artigo analisa os principais programas direcionados à educação durante o Governo Bolsonaro, considerando a particularidade brasileira de capitalismo dependente. Realiza uma pesquisa qualitativa, a partir do levantamento bibliográfico sobre a temática e de uma pesquisa documental, com destaque para os Programas “Conta pra Mim”, Escola CívicoMilitares e “Future-se”. Os resultados foram sistematizados em dois tópicos: 1) repercussões do capitalismo dependente na política de educação; 2) política de educação e os direcionamentos do Governo Bolsonaro; 2.1) Programa “Conta pra Mim”; 2.2) Programa Escolas Cívico-Militares; e 2.3) “FUTURE-SE”. Verifica, ainda, a presença de traços neofascistas no Governo Bolsonaro que estimularam o processo em curso de privatização da educação, militarização dos espaços educacionais e do controle ideológico da classe trabalhadora e seus descendentes.
QUEM TEM FOME NO BRASIL? análise da insegurança alimentar a partir de raça e gênero
Authors: Henig Edir Vilmar
Published: January 2025

O Brasil voltou recentemente ao mapa da fome da Organização das Nações Unidas. Esta realidade coloca a classe trabalhadora em situação de vulnerabilidade, o que justifica a necessidade de se abordar o tema em estudos. Neste sentido, este artigo tem por objetivo refletir a situação de insegurança alimentar dos brasileiros a partir do recorte de raça e gênero. Os dados para a discussão foram coletados juntos à plataforma SIDRA do Instituto Brasileiro de Geografia e Estatística (IBGE), amparado por referências bibliográficas críticas que dão sustentação à discussão. O debate é travado pelas vias das contradições existentes no modo de produção capitalista, fruto de uma construção histórica e que deve ser percebido em sua totalidade, tendo assim o materialismo histórico e dialético como instrumento de interpretação da realidade. É possível destacar que em relação aos brancos, as pessoas negras apresentam maior propensão à insegurança alimentar. Contudo, a situação é mais grave entre as trabalhadoras negras.
Percursos literários na trilogia de filmes de João César Monteiro: Recordações da casa amarela (1989), A comédia de Deus (1995) e As bodas de Deus (1998)
Authors: Santos Fernanda Cristina da Encarnação dos
Published: January 2025

João César Monteiro (1939-2003) foi um cineasta português integrante do movimento Novo Cinema. O seu primeiro filme remonta à década de 70. A partir daí construiu uma filmografia baseada na crítica social e na transgressão moral, sobretudo do seu personagem maior, João de Deus, a quem emprestou o nome e o corpo, uma vez que o realizador também era ator. Nas décadas de 80 e 90 contou as peripécias do personagem em cinco filmes, sendo que três deles formam, sequencialmente, uma trilogia de acontecimentos na vida de João de Deus e no seu comportamento marginal e transgressor. Pretende-se, neste artigo, analisar algumas referências literárias nos filmes Recordações da Casa Amarela (1989), A Comédia de Deus (1995) e As Bodas de Deus (1998), com as quais João César Monteiro dialogou, trazendo uma linguagem cinematográfica nova, eivada de complexas teias de sentido estético, literário e filosófico.
Memória, discurso e sujeito: o entrelugar do surdo entre L1 e L2
Authors: Silva Cleyce Carla Pereira da , Santos Thatiana Silva , Silva Filho Marcelo Nicomedes dos Reis
Published: January 2025

A presente investigação tem por finalidade analisar como se constitui a produção de sentidos na escrita do sujeito surdo, pondo em destaque as possíveis marcas da memória de si como sujeito que requisita um eu individual e, ao mesmo tempo, reconhece-se coletivo e sobretudo, diferente dos demais. Neste estudo, trazemos uma proposta que se insere no escopo teórico-metodológico da Análise de Discurso materialista francesa e refletiremos a luz de autores como: Pêcheux (1999; 2009), Orlandi (2007; 2015), Indursky (2000; 2013) dentre outros. Para tratarmos sobre a Libras e a relação de L1 e L2: Fernandes e Moreiras (2009), Quadros (1997), dentre outros. O corpus em análise foi coletado a partir de uma postagem na rede social Facebook, tendo seus recortes feitos resultando em 2 sequências discursivas -SDs. Nossa proposta é relacionar a discussão teórica presente na AD aqui, pelas seguintes categorias: memória/interdiscurso; analisamos a relação que a escrita do surdo desempenha e evoca sentidos que já existem na memória e no interdiscurso bem como a intrínseca relação que a Libras, L1 do surdo se faz presente no português como marca identitária desse sujeito marcando também a posição-sujeito que este assume. A análise do corpus aponta para a demarcação de posições-sujeito filiadas à defesa de identidades surdas possíveis pelo discurso que suporta a surdez como diferença socioantropológica e não pelo discurso filiado à deficiência, funcionamentos estes que são evocados pela memória presente nas formações discursivas e pelos pré-construídos disponíveis no interdiscurso.
Fantasmagorias canônicas na obra De passagem mas não a passeio: literatura marginal periférica desconstruindo a poiésis
Authors: Gomes Francisco Alves , Ferreira Cacio José , Bottos Júnior Norival
Published: January 2025

A literatura periférica espraia-se visceralmente no sistema literário brasileiro, ao incorporar inúmeros matizes estilísticos, contribui de maneira efetiva para a criação de redes de pensamento que possam redimensionar aspectos importantes no que diz respeito ao cânone, ao poeta e a poesia, ou seja, repensar a própria condição da literatura no mundo contemporâneo. Neste sentido, nosso ensaio visa analisar algumas dessas condições de trânsito teórico no livro De passagem mas não a passeio, da poeta Dinha, nome representativo na literatura periférica de autoria feminina. A obra, ao evocar poetas de extração canônica, nos coloca uma série de questionamentos sobre a maquinaria do texto poético, bem como uma discussão sobre o que é ser poeta, tendo em vista que a ideia de metapoesia é sistematizada ao longo do livro, criando assim um todo orgânico a enlaçar elementos canônicos com a experiência de vida, elemento fulcral no desenho identitário dessa literatura que reinscreve os padrões legitimados pelo cânone.
A natureza da ofensa dos termos derivados de animais
Authors: Silva Giovanna Costa , Basso Renato Miguel
Published: January 2025

Nesse artigo exploraremos propriedades semânticas, morfológicas, e a natureza da ofensa dos termos derivados de nomes de animais, ou seja, qual é o domínio de significado a partir do qual um dado termo é ofensivo. Num primeiro momento, baseados em Basso e Silva (2024), mostraremos que os pejorativos derivados de nomes de animais podem ser classificados como ofensas, injúrias e injúrias de gênero, para então explorar algumas de suas características morfossintáticos, e então investigar as razões por trás da pejoratividade desses termos, se eles têm a ver com comportamento sexual, capacidades cognitivas, formato do corpo, entre outros. Este não é um trabalho exaustivo, mas pode ser visto como um panorama das ofensas baseadas em nomes de animais e dos valores atualmente em jogo na sociedade brasileira quando se trata de ofensas.
Léxico disponible español de estudiantes de secundaria y bachillerato: incidencia de la variable sexo
Authors: Herranz-Llácer Cristina V.
Published: January 2025

El objetivo de este artículo es investigar sobre la incidencia de la variable sexo en el léxico disponible de 184 estudiantes de 1.º de secundaria y 1.º bachillerato, y analizar si existen diferencias en el número de palabras, y en el uso que hacen varones y mujeres. Para el desarrollo del estudio se ha utilizado el índice de disponibilidad léxica (IDL), el índice de compatibilidad (IC) y el porcentaje de disponibilidad léxica retenida (PDR) en ocho centros de interés (cinco tradicionales y tres novedosos). Así, tras la recogida de información y el análisis de los resultados, se ha visto reflejada la existencia de diferencias entre ambos repertorios. La principal conclusión versa sobre la existencia, en determinadas áreas, de un uso diferenciado del vocabulario.
El prefijo super- con valor de intensificación: un reto para la ortografía actual
Authors: Delgado-Olmos Alicia
Published: January 2025

Existe entre los hispanohablantes una tendencia generalizada a la adhesión a las normas ortográficas, presumiblemente ligada al mantenimiento de la propia imagen. Las desviaciones suelen responder, en especial en entornos juveniles o virtuales, a una voluntad deliberada de pertenencia a cierto grupo o al desconocimiento. Uno de los fenómenos con mayores dificultades ortográficas es el uso intensificador del prefijo super-, en auge en las últimas décadas. Por ello, se plantea en este estudio un análisis panhispánico de las frecuencias de las diferentes variantes gráficas y su distribución en corpus con distintos grados de familiaridad, al tiempo que se buscan las posibles causas. Se valora, paralelamente, si ciertas consonantes iniciales en las bases pueden influir en la selección de dichas variantes.