bluuebunny/crossref_metadata_2025 huggingface dataset:
Blood, saliva and urine maresin-1 and malondialdehyde may be useful biomarker in patients with polycystic ovary syndrome: a prospective study
Authors: Yavuz Adem , Ugur Kader , Karaca Karagoz Zuhal , Ayan Durmus , Aydin Suleyman
Published: April 2022

Background: Maresin-1 (MaR1) plays a major role in many inflammatory disorders. Polycystic ovary syndrome (PCOS) aside from a hormonal disorder, an inflammation might also contribute to PCOS and its metabolic associations. Therefore, the purpose of this prospective study first time was to find out the blood, saliva and urine levels of MaR1 in PCOS patients and evaluate the correlations with other metabolic and hormonal parameters. Methods: Thirty PCOS patients and 30 matched healthy controls were enrolled to prospective case control study. Blood, urine and saliva samples were simultaneously collected from participants after overnight fasting. MaR1 levels in blood, urine and saliva samples were determined by enzyme-linked immunosorbent assay. Ferriman-Gallwey score, anthropometric, hormonal and some other metabolic parameters were also recorded. Regression analysis was preformed to find out the relationship between MaR1, C-reactive protein (CRP) and malondialdehyde (MDA), and hormonal and metabolic parameters. Results: Patients with PCOS compared with control women had higher MDA and CRP and decreased MaR1 levels. Blood, urine and saliva MDA and MaR1 levels were similar and indicated parallel decrease or increase in the PCOS and control groups. Furthermore, regression analysis indicated that blood CRP and MDA was positively associated with luteinizing hormone (LH) and fasting insulin (FI) in PCOS group (p < 0.05) while blood, urine and saliva MaR1 was negatively associated with CRP and MDA. Conclusions: Present results (MaR1, CRP and MDA together) in case of PCOS suggests that decreased MaR1 and elevated MDA and CRP levels in patients with PCOS and may be considered as a useful early biomarker (especially MaR1) in diagnosis of PCOS disease that has not been previously reported and regular monitoring of their levels could be helpful in clinical decisions.
Spontaneous Regression of Cancer: Revealing Granulocytes and Oxidative Stress as the Crucial Double-edge Sword
Authors: Žarković Neven , Jaganjac Morana , Žarković Kamelija , Gęgotek Agnieszka , Skrzydlewska Elżbieta
Published: April 2022

Background: It is commonly believed that cancer development is irreversible, organ-specific as well as systemic malignant disorder, often associated with harmful oxidative stress and inflammation. However, there are also well-documented cases of spontaneous cancer regression, the causative mechanisms of which are not understood. It is known that inflammation is a negative pathophysiological process that may support the development of cancer, but it is also believed that the immune system as well as oxidative stress play important roles in prevention of cancer development and defense against tumor progression. Hence, in animal models spontaneous regression of cancer could be mediated by rapid inflammatory response of granulocytes, acting against cancer mostly as innate immune response. In addition, the administration of granulocytes at the site of solid tumors can lead to tumor regression or can slow down tumor growth and extend the overall survival of animals. In both cases, similar to the radiotherapy, surgery and various chemotherapies, oxidative stress occurs generating lipid peroxidation product 4-hydroxynonenal (4-HNE). This “second messenger of free radicals” acts as growth regulating signaling molecule that exerts relatively selective cytotoxicity against cancer cells. Conclusions: We hypothesize that abundant inflammation and metabolic changes caused by cancer and oxidative stress producing of 4-HNE may be crucial mechanisms for spontaneous cancer regression.
Structural Characterization and Comparative Analyses of the Chloroplast Genome of Eastern Asian Species Cardamine occulta (Asian C. flexuosa With.) and Other Cardamine Species
Authors: Raman Gurusamy , Park SeonJoo
Published: April 2022

Background: Cardamine flexuosa is considered to be two separate species in the Cardamine genus based on their geographical distribution: European C. flexuosa and Eastern Asian C. flexuosa. These two species have not shown any morphological differences to distinguish each other. Recently, the Eastern Asian species has been regarded as Cardamine occulta by their ecological habitats. Therefore, we are interested in analyzing the C. occulta chloroplast genome and its characteristics at the molecular level. Methods: Here, the complete chloroplast (cp) genome of C. occulta was assembled de novo with next-generation sequencing technology and various bioinformatics tools applied for comparative studies. Results: The C. occulta cp genome had a quadripartite structure, 154,796 bp in size, consisting of one large single-copy region of 83,836 bp and one small single-copy region of 17,936 bp, separated by two inverted repeats (IRa and IRb) regions of 26,512 bp. This complete cp genome harbored 113 unique genes, including 80 protein-coding genes, 29 tRNA, and four rRNA genes. Of these, six PCGs, eight tRNA, and four rRNA genes were duplicated in the IR region, and one gene, infA, was a pseudogene. Comparative analysis showed that all the species of Cardamine encoded a small variable number of repeats and SSRs in their cp genome. In addition, 56 divergences (Pi > 0.03) were found in the coding (Pi > 0.03) and non-coding (Pi > 0.10) regions. Furthermore, KA/KS nucleotide substitution analysis indicated that thirteen protein-coding genes are highly diverged and identified 29 amino acid sites under potentially positive selection in these genes. Phylogenetic analyses suggested that C. occulta has a closer genetic relationship to C. fallax with a strong bootstrap value. Conclusions: The identified hotspot regions could be helpful in developing molecular genetic markers for resolving the phylogenetic relationships and species validation of the controversial Cardamine clade.
Can cell and gene therapies improve cognitive symptoms in Parkinson’s disease?
Authors: Lelos Mariah J.
Published: April 2022

Advanced therapeutic medicinal products (ATMPs), including cell and gene therapies, are in development for Parkinson’s disease (PD). In many cases, the goal is to replace the lost dopamine (DA), which is anticipated to improve motor dysfunctions associated with DA loss. However, it is less clear the extent to which these therapeutic interventions may impact on the wide range of cognitive symptoms that manifest as the disease progresses. Although the accepted perception is that cognitive symptoms are predominately non-DAergic in origin, in this commentary, it is argued that several, specific cognitive processes, such as habit formation, working memory and reward processing, have been reported to be DA-dependent. Furthermore, there is evidence of DAergic medications modulating these behaviours in PD patients. Finally, the potential for cell and gene ATMPs to influence these symptoms is considered. It is concluded that DA replacement through ATMPs is likely to improve certain DA-dependent symptoms, but only sparse clinical data are currently available and the ability to precisely titrate DA transmission is likely to be complex.
Elevated Serum Retinol Binding Protein 4 is Associated with the Risk of Diabetic Cardiomyopathy
Authors: Shan Haihua , Ji Yanjing , Gu Haibo , Li Hui , Zhu Jing , Feng Yu , Peng Hao , You Tao , Gu Xiaosong
Published: April 2022

Background: Retinol binding protein 4 (RBP4), a biomarker for insulin resistance in type 2 diabetes (DM), is increased in heart failure. This case-control study aims to determine the association between serum RBP4 levels and diabetic cardiomyopathy (DCM). Methods: Demographic and clinical data were obtained from 245 DM patients and 102 non-diabetic controls. RBP4 levels were measured using ELISA. The association between RBP4 and DCM was evaluated using multivariate logistic regression and restricted cubic splines (RCS) in DM patients. Results: We showed that serum RBP4 levels were higher in DCM patients than in DM patients without DCM or the controls. Multivariate analysis adjusted by age, gender, body mass index, diabetes duration, left ventricular ejection fraction, insulin treatment, triglycerides, low-density lipoprotein cholesterol, estimated glomerular filtration rate, diabetic retinopathy, diabetic nephropathy, diabetic neuropathy and log N-terminal proBNP showed a significant association between RBP4 and DCM (highest vs. lowest tertile OR 16.87, 95% CI: 6.58, 43.23, p < 0.001). RCS displayed a positive linear correlation between RBP4 levels and the risk of DCM in diabetes (p = 0.004). Adding RBP4 to a basic risk model for DCM improved the reclassification (Net reclassification index: 87.86%, 95% CI: 64.4%, 111.32%, p < 0.001). Conclusions: The positive association between serum RBP4 and DCM suggested the role of RBP4 as a potential diagnostic biomarker for distinguishing DCM in patients with DM.
The Utility of the SYNTAX Score II and SYNTAX Score 2020 for Identifying Patients with Three-Vessel Disease Eligible for Percutaneous Coronary Intervention in the Multivessel TALENT Trial: A Prospective Pilot Experience
Authors: Ninomiya Kai , Serruys Patrick W. , Garg Scot , Hara Hironori , Masuda Shinichiro , Kageyama Shigetaka , Kotoku Nozomi , Sevestre Emelyne , Kumar Abhishek , O’Kane Peter , Zaman Azfar , Farah Bruno , Magro Michael , Oemrawsingh Rohit M. , Möllmann Helge , Meneveau Nicolas , Achenbach Stephan , Lemoine Julien , Allali Abdelhakim , Gallagher Sean , Wykrzykowska Joanna , Lesiak Maciej , Silvestri Marc , Wijns William , Sharif Faisal , Onuma Yoshinobu
Published: April 2022

Background: Personalized prognosis plays a vital role in deciding between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with three-vessel disease (3VD). The aim of this study is to compare the modality of revascularization chosen by the local heart team to that recommended by using individualized predictions of medium, and long-term all-cause mortality amongst patients with 3VD screened in the Multivessel TALENT trial. Methods: The SYNTAX score II (SS-II) and SS-2020 were evaluated in 200 consecutive patients by a core laboratory and compared to the decision of the “on site” heart team. Results: According to the SS-II, CABG was the recommended treatment in 51 patients (25.5%) however 34 (66.6%) of them received PCI. According to SS-2020 the predicted absolute risk differences (ARD) between PCI and CABG were significantly higher in patients receiving CABG compared to those treated by PCI for major adverse cardiovascular and cerebrovascular events, a composite of all-cause mortality, stroke or myocardial infarction at 5-years (8.8 ± 4.6% vs 6.0 ± 4.0%, p < 0.001) and all-cause mortality at 5- (5.2 ± 3.5% vs 3.7 ± 3.0%, p = 0.008) and 10-years (9.3 ± 4.8% vs 6.2 ± 4.2%, p < 0.001). Based on the novel threshold of equipoise (individual absolute risk differences [ARD] <4.5%), 133 patients were eligible for PCI however 23 of them underwent CABG; conversely, amongst the 67 patients where CABG was recommendation (individual ARD >4.5%), only 19 received it. Conclusions: Despite the robustness of the risk models proposed for screening, several deviations from the recommended mode of revascularization were observed by the core laboratory among the first 200 patients with 3VD screened in the Multivessel TALENT trial. Clinical Trial Registration: ClinicalTrials.gov reference: NCT04390672.
Effects of Circuit Training Program on Cardiovascular Risk Factors, Vascular Inflammatory Markers, and Insulin-like Growth Factor-1 in Elderly Obese Women with Sarcopenia
Authors: Jung Won-Sang , Kim Yae-Young , Kim Jeong-Weon , Park Hun-Young
Published: April 2022

Background: Sarcopenic obesity is caused by a decrease in muscle mass and an increase in body fat due to aging, and has been the cause of cardiovascular diseases such as hypertension, diabetes, hyperlipidemia, and arteriosclerosis and high inflammatory conditions. However, there is a lack of research on the effects of long-term exercise training as regards to the body composition and blood-related physiological indicators. Therefore, the purpose of this study was to investigate the influences the effect of circuit exercise training for 12 weeks on cardiovascular risk factors, vascular inflammatory markers, and insulin-like growth factor-1 (IGF-1) in elderly obesity women with sarcopenia. Methods: A total of 28 elderly obese Korean women with sarcopenia (75.0 ± 5.1 years) were randomly assigned either to a control group (CG, n = 14) or an exercise group (EG, n = 14). The EG performed circuit exercise training for 25–75 minutes (gradually incremental) three times per week over a period of 12 weeks, while the CG maintained their usual daily lifestyle during the intervention period. Pre- and post-intervention evaluations were performed on selected cardiovascular risk factors, inflammatory markers, and IGF-1. Results: The EG group exhibited improved body composition (i.e., body mass index, fat-free mass, % fat mass, waist-to-hip ratio; all p < 0.030, η2 > 0.169), Cardiovascular risks factor (i.e., heart rate, systolic blood pressure, rate pressure product, high-density lipoprotein cholesterol, total cholesterol/HDL-C ratio, triglyceride/HDL-C ratio, low-density lipoprotein cholesterol/HDL-C ratio, brachial-ankle pulse wave velocity, fasting plasma insulin, homeostasis model assessment-insulin resistance; all p < 0.042, η2 > 0.150), Inflammatory markers (i.e., high sensitivity C-reactive protein, interleukin-6; all p < 0.045, η2 > 0.146), and IGF-1 (p = 0.037, η2 = 0.157). Conversely, there were no significant changes observed in CG. Conclusions: Twelve weeks of circuit training had a positive effect on the improvement in cardiovascular risk factors, vascular inflammatory markers, and IGF-1 in elderly obese women with sarcopenia.
Exercise Training in Patients with Heart Failure: From Pathophysiology to Exercise Prescription
Authors: Cuomo Gianluigi , Di Lorenzo Anna , Tramontano Anna , Iannone Francesca Paola , D’Angelo Andrea , Pezzella Rita , Testa Crescenzo , Parlato Alessandro , Merone Pasquale , Pacileo Mario , D’Andrea Antonello , Cudemo Giuseppe , Venturini Elio , Iannuzzo Gabriella , Vigorito Carlo , Giallauria Francesco
Published: April 2022

Heart failure (HF) is a chronic, progressive, and inexorable syndrome affecting worldwide billion of patients (equally distributed among men and women), with prevalence estimate of 1–3% in developed countries. HF leads to enormous direct and indirect costs, and because of ageing population, the total number of HF patients keep rising, approximately 10% in patients >65 years old. Exercise training (ET) is widely recognized as an evidence-based adjunct treatment modality for patients with HF, and growing evidence is emerging among elderly patients with HF. We used relevant data from literature search (PubMed, Medline, EMBASE) highlighting the epidemiology of HF; focusing on central and peripheral mechanisms underlying the beneficial effect of ET in HF patients; and on frail HF elderly patients undergoing ET. Since many Countries ordered a lockdown in early stages pandemic trying to limit infections, COVID-19 pandemic, and its limitation to exercise-based cardiac rehabilitation operativity was also discussed. ET exerts both central and peripheral adaptations that clinically translate into anti-remodeling effects, increased functional capacity and reduced morbidity and mortality. Ideally, ET programs should be prescribed in a patient-tailored approach, particularly in frail elderly patients with HF. In conclusion, given the complexity of HF syndrome, combining, and tailoring different ET modalities is mandatory. A procedural algorithm according to patient’s baseline clinical characteristics [i.e., functional capacity, comorbidity, frailty status (muscle strength, balance, usual daily activities, hearing and vision impairment, sarcopenia, and inability to actively exercise), logistics, individual preferences and goals] has been proposed. Increasing long-term adherence and reaching the frailest patients are challenging goals for future initiatives in the field.
Perbankan syariah
Authors: Azifah Nurul
Published: April 2022

Bank syariah atau dalam istilah internasional dikenal sebagai Islamic Banking atau disebut dengan interest free banking. Kata Islamic tidak dapat dilepaskan dari asal usul sistem perbankan itu sendiri. Bank syariah pada awalnya dikembangkan sebagai bentuk suatu respon dari beberapa kelompok ekonom muslim dan kalangan kalangan praktisi perbankan muslim yang berupaya memenuhi dan mengakomodasi desakan dari berbagai pihak yang menginginkan tersedianya lembaga jasa keuangan yang dilaksanakan sesuai dengan prinsip islam. Sektor keuangan islam sangat mempengaruhi pertumbuhan ekonomi dalam tiga dekade terakhir. Institusi keuangan syariah seperti bank syariah telah mampu bersaing dan dan beroperasi secara efektif dan efisien. Industri perbankan syariah berkontribusi pada stabilitas sistem keuangan dan lebih mampu menahan guncangan krisis (Rizvi (Rizvi et al, 2019). Pada tahun 2007 terjadi krisis pinjaman (subprime) di Amerika Serikat yang berimbas langsung terhadap kestabilan ekonomi global, semua lembaga-lembaga keuangan tidak stabil dan ekonomi sedang buruk sementara perbankan syariah tetap beroperasi secara stabil (Mat Rahim & Zakaria, 2013; N. Trad et al 2017).
Resume Konsep dan Teori Uang Dalam Perspektif Islam
Authors: Irhamni
Published: April 2022

Uang dalam Islam pada mulanya dicerminkan dalam dirham sebagai alat tukar dan alat nilai, kemudian berkembang menjadi uang emas dan perak dengan nama dinar (negara Arab). Uang dan fungsinya sebagai alat tukar dan alat nilai dikemukakan juga oleh Ibn Khaldun dan al-Ghazali.
GAMBARAN UMUM PERBANKAN SYARIAH DI INDONESIA
Authors: Ihsan Ahmad
Published: April 2022

Bank syariah merupakan lembaga keuangan yang sangat penting bagi masyarakat Indonesia sebagai lembaga yang mampu menggambarkan masyarakat yang sejahtera dengan produknya ketika diimplementasikan secara konsisten. Namun pengertian bank syariah di masyarakat masih ragu karena bank syariah sama dengan bank konvensional. Pemahaman yang kurang tepat dapat dijelaskan secara filosofis, yuridis dan sosiologis. Bank syari’ah pada awalnya dikembangkan sebagai suatu respon dari kelompok ekonom dan praktisi perbankan muslim yang berupaya mengakomodasi desakan dari berbagai pihak yang menginginkan agar tersedia jasa transaksi keuangan yang dilaksanakan sejalan dengan nilai moral dan prinsip-prinsip syari’ah Islam. Utamanya adalah berkaitan dengan pelarangan praktek riba, kegiatan maisir (spekulasi), dan gharar (ketidakjelasan).
Mindsponge-based theoretical reasoning on the political psychology that begets and empowers a dictator
Authors: Vuong Quan-Hoang
Published: April 2022

This conceptual paper represents my first attempt to tackle a difficult research problem (at least for me), employing the mindsponge concept facilitated by the BMF analytical approach. These ‘weapons’–as we at AISDL usually call them–have shown usefulness and capabilities to shed light on numerous challenging research problems in social sciences and humanities.
Investigating Lexical Concept and Semantic Representation of Covid-19 in Coronavirus Corpus: A Corpus-Based Study
Authors: Citraresmana Elvi , Erlina  , Sidiq Inu Isnaeni
Published: April 2022

This article discusses the lexical and semantic representation through the collocation that appeared in the Coronavirus Corpus. This research investigates the frequent collocates that appeared together with the node word Corona and find out how those collocates construct the meaning through the linguistic system and conceptual system as they are involved in lexical representation. This research offers a new insight into teaching language using Lexical Concepts and Cognitive Models (Evans, 2009). The data collected are from the Coronavirus corpus by using the corpus-based method. The strength of the keywords and collocate is measured by using Mutual Information (MI). The MI was set in 5; therefore, three lexemes resulted, i.e., cases, patients, and outbreak. The data were analyzed using the lexical concept and cognitive model proposed by Evans (2009). The research results, in general, reveal that the information is coming from the “authorized institution” and “government’s representative”; it needs “the official approval or agreement” before publishing to the media, and in the passive form, it describes the foregrounded information and agentless informational assertion. Therefore, the information should be accurate and firm. However, another lexical concept reveals that the information is terrorizing and terrifying; the educated and trained person should also conduct the treatment.
Ô nhiễm môi trường lao động
Authors: Anh Quỳnh
Published: April 2022

Ô nhiễm môi trường lao động
Hubungan dan pembagian kerja dalam pengelolaan koperasi
Authors: Arief A. Anggie Zabrina
Published: April 2022

Cooperative management is a professional activity carried out by cooperatives to assist all cooperative members in achieving their goals. Cooperative management is not based on coercion of authority, but through involvement and participation. Organizational management in cooperatives, an organization that produces an arrangement of tasks or responsibilities consisting of parts that are integrated through relationships between parts within the cooperative. In order for cooperatives to run well, cooperatives need to be run professionally and involve elements such as member meetings, management, members, and supervisory bodies.Keywords: Cooperative Management, relations and division of labor in cooperatives
Levels of Self-Threat and Compensatory Consumption
Authors: Kim Jin , Wong Jared
Published: April 2022

Previous research has demonstrated that consumers experiencing a self-threat can cope with the threat by engaging in compensatory consumption; that is, they consume products symbolic of the threatened attribute (e.g., sophisticated books symbolic of intelligence) to signal to themselves and others the possession of the threatened attribute. Little research, however, has examined how levels (i.e., severity or magnitude) of self-threat relate to compensatory consumption. In the present research, we manipulate levels of threat in the domain of intelligence and argue that—unlike a low-level threat—a high-level threat can discourage compensatory consumption. While compensatory consumption may sufficiently reduce self-discrepancy from a low-level threat, it may not sufficiently reduce self-discrepancy from a high-level threat. We therefore hypothesize that consumers will be less likely to engage in compensatory consumption after experiencing a high-level (vs. low-level) threat. Across four studies and an internal meta-analysis, we find directional (but not significant) evidence in support of our hypothesis.
Forschungsethik in Organisationen. Ein Überblick über Herausforderungen und praktische Umgangsweisen
Authors: Scheytt Carla , Pflüger Jessica
Published: April 2022

The consideration of ethical principles to protect the research subjects is a central element of empirical social research but is only marginally discussed in Industrial Relations and Organization Research. Existing debates focus primarily on questions of data protection and anonymization. However, due to the nature of the research field, specific ethical challenges arise: First, the research field is organized hierarchically. Employees may face sanctions if they refuse to participate or if sensitive data are not sufficiently anonymized or protected. Second, the field is characterized by a high degree of formal and informal practices. Ensuring confidentiality is particularly challenging here. We want to discuss these and similar problems for qualitative research projects based on existing literature. The article aims (1) to provide practical advice for dealing with research ethics issues throughout the research process, and (2) to initiate a broader discussion of research ethics specifics in Industrial Relations and Organization Research.
Perimenopausal invasive complete hydatidiform mole: a rare encounter
Authors: Rajbhandari Aasiya , Malla Vaidya Karishma , Dahal Bibhuti
Published: April 2022

Invasive mole, classified under the gestational trophoblastic diseases, comprises of hydropic chorionic villi invading the underlying myometrium, blood vessels or extra-uterine sites. They are usually diagnosed clinically and are treated with chemotherapy. Thus, surgery is rarely performed owing to good response to chemotherapy and preservation of fertility, since most women are in reproductive age. Thus, these specimens are rarely encountered by the pathologists. Here, we report a case of invasive mole in a 48 year old female with persistent elevation of serum beta HCG levels and completed family status who underwent hysterectomy and was diagnosed as a case of invasive mole on histopathologic examination.
Mucinous lesions of the appendix: a histopathological study
Authors: Shrestha Oshan , Baral Reetu
Published: April 2022

Background: Mucinous lesions of the appendix are frequently misinterpreted in histopathological examination due to their relative rarity. Our study focuses on interpreting the histopathological spectrum of such lesions and understanding the disease burden of appendiceal mucinous lesions in a tertiary centre.
Materials and Methods: This was a retrospective cross-sectional study conducted in the Department of Pathology. Gross and microscopic findings of appendicectomy specimens with mucinous lesions were analysed and classified according to the latest WHO 2019 recommendation.
Results: Seven hundred and forty appendicectomy specimens were received during the study period out of which nine appendix (1.2%) had mucinous lesions. Five (55.6%) of these lesions had a mucinous neoplasm while four of them (44.4%) were non-neoplastic. The most common lesion was low-grade appendiceal mucinous neoplasm (n=4; 44.4%). Two cases (22.2%) were retention cysts and there was one case each of mucinous adenocarcinoma, appendiceal diverticulosis, and endometriosis-associated mucinous metaplasia of the appendix. The mucinous neoplasms were significantly more common in females (80%). High-grade appendiceal mucinous neoplasms and serrated lesions or polyps weren’t seen in our study.
Conclusions: Mucinous lesions of the appendix are often incidental findings in patients operated for symptoms of acute appendicitis. Low-grade appendiceal mucinous neoplasms are the most common among them. Thorough knowledge of the neoplastic mimics and careful gross, as well as microscopic examination, is a must for proper diagnosis and staging since it has a significant impact on further patient management and prognostication.
A (I)legalidade do Recrutamento Restritivo de Policiais Militares Femininas
Authors: Pivetta Luciane Benedita Duarte
Published: April 2022

A reduzida proporção de mulheres em órgãos de segurança pública ainda é um padrão ao redor do mundo.  No entanto, a conscientização acerca da necessidade de promover a igualdade de gênero tem estimulado a implementação de políticas públicas para incentivar o recrutamento de policiais femininas, especialmente em países desenvolvidos. Infelizmente o Brasil tem caminhado em direção oposta a este processo de integração feminina nas forças policiais. Este estudo investigou os processos seletivos mais recentes para ingresso na polícia militar em todas as unidades federativas brasileiras, bem como as leis estaduais que regulam a entrada nessa instituição, verificando, de maneira inédita, que 74% dos últimos editais impuseram restrições ao ingresso de mulheres. Ao invés de promover a diversidade, incentivando o recrutamento feminino, estes processos seletivos exacerbaram o fosso existente entre homens e mulheres na polícia militar brasileira. Ademais, tais limitações foram injustificadas, representando violações aos direitos de igualdade e não-discriminação, assegurados não somente na Constituição Federal de 1988, mas também em diversos tratados internacionais ratificados pelo Brasil.
ELETROQUÍMICA FORENSE APLICADA NA REVELAÇÃO DE IMPRESSÕES DIGITAIS LATENTES
Authors: Assis Alexandro Mangueira Lima de , Costa Cristiane Vieira , Ribeiro Adriana Santos
Published: April 2022

Impressões digitais latentes coletadas em cenas de crime são vestígios frequentes e relevantes às investigações policiais, entretanto ainda se observa baixas taxas de sucesso quanto à qualidade de sua revelação com as técnicas convencionais, especialmente no caso de superfícies metálicas. Nesse contexto, o trabalho apresenta uma estratégia de revelação de impressões digitais latentes através da eletrodeposição de polímeros condutores em superfícies metálicas, que se mostra como uma metodologia promissora para a Química Forense. Os resultados apresentaram detalhes completos das cristas papilares e impressões digitais totalmente identificáveis, mostrando se tratar de uma metodologia simples, eficiente, barata e de baixa toxicidade.
Molecular Prevalence of Ent amoeba histolytica and Ent amoeba dispar Infection among Aboriginal Communities in the Southern Region of Perak, Malaysia
Authors: Saidin Syazwan , Abu Bakar Adibah , Bun Poh Remmy Keong , Raja Khairuddin Raja Farhana , Md Zain Badrul Munir
Published: April 2022

INTRODUCTION: In Malaysia, there are little up-to-date data on the prevalence of Ent amoeba spp. and most of the previous studies were carried out using the conventional insensitive method of stool microscopic examinations. MATERIALS AND METHODS: A cross-sectional study was conducted from September 2018 to Mac 2019 in the three villages of Orang Asli communities at Slim River, Perak using the molecular assay. Risk factors associated with Ent amoeba spp. infection was assessed by analysing questionnaire responses obtained from the study participants. RESULTS: From the 55 stool samples collected, molecular prevalence revealed 7.3% and 9.1% E. histolytica and E. dispar infection respectively. Infection was due to indiscriminate defecation and not washing hands after playing with soil or gardening, as well as associated with gastrointestinal symptoms. CONCLUSION: This study showed that there is still an ongoing transmission of Ent amoeba spp. among the studied population, thus warrants the implementation of specific prevention and control strategies of this infection in Malaysia.
Impact of Public Expenditures on the Dynamics of Economic Development of the Republic of Bulgaria
Authors: Mitkov Milen
Published: April 2022

Introduction. Regardless of the degree of government intervention in the economy, government spending is huge and often dominant in fiscal policy. Given the fact that costs are the main tool for fulfilling the economic and social functions of the state, adequate measures are needed to maximize their provision. The main goal of economic policy in Bulgaria is to ensure high economic growth in order to reach the average levels of Gross Domestic Product (GDP) per capita in the EU, therefore it is requires to identify all instruments that can affect the level of aggregate production.
Aim and tasks. The purpose of this study is to analyze the main factors influencing the effectiveness of government spending on the basis of in-depth analysis and guidance on the implementation of public spending in the Republic of Bulgaria. The following main tasks have been set for the realization of the stated goal: disclosure of the essence and content, through theoretical statements about gross domestic product and government spending; carrying out an analysis of gross domestic product for the period 2010-2020; carrying out an analysis of government expenditures for the period 2010-2020; establishing a link between development of gross domestic product and government spending for the period 2010-2020.
Results. Public spending has the potential to play the role of a kind of public lever for reducing the risks of poverty and social exclusion only when it is focused on the real causes of the problem and reaches the ultimate beneficiaries of the system. In 2020, compared to 2010, the gross domestic product increased by a little over BGN 46 million or by 63.8%.  The effect of the crisis was reflected in the main macroeconomic aggregates, with a negative rate of -0.4 compared to 2019. In 2020, compared to 2010, government spending increased by just over BGN 20 million or 76.4%. 
Conclusions. During the considered period 2010-2020, there is a continuous economic growth both compared to the base year and compared to each subsequent year. For the entire period of the study, the pace of development of government expenditures outpaces the pace of GDP development. For the period 2010-2020 consolidated expenditures form a real share of redistribution through public finances in the ratio of about 35-40 percent of gross domestic product.
The Dual-Natured Direction of Intellectual Capital Formation in the System of Higher Education
Authors: Yereshko Julia , Ageieva Iryna , Gura Olga , Tkach Oleksandr
Published: April 2022

Introduction. In а modern world, higher education institutions (HEIs) play a key role in the development of science, technology, industry, economics and, most importantly, the development of humans, their individual and social consciousness, which are key innovative resources for sustainable development. At the same time, the specificity of the HEIs’ intellectual capital leads to the formulation of a paradox: higher education is both the most and the least (at least domestic one) intellectualized economic structure. HEIs are a source of knowledge, their staff, students and graduates – its carriers and, at the same time, domestic universities are stagnating in their development, not using this knowledge as a value-generating income factor.
Aim and tasks. The purpose of the study is to develop a model in order to analyze the formation and implementation of HEIs’ intellectual capital in the entire structure of their economic activities. The model is proposed in order to identify the motives and ways of its development and the awareness of its main feature – a dual-natured direction, manifested for universities, scientific and teaching staff, students, business and state.
Results. The article deals with an analysis of possible directions for achieving the goals of the HEI in the implementation of its chosen business model, as well as the relationship of elements of intellectual capital, should be based on the proposed model, which allows its management to ensure the synergistic effect of the totality of its components.
Conclusions. The study presents the main sources of innovative advantage, and also describes how the intellectual capital of the HEI is related to its market value. It is a process of commercialization of knowledge, which generates intellectual capital at the HEI, giving it not only scientific and educational value, but also market value. Collaboration between HEIs and industry offers researchers the opportunity to increase the value of their intellectual capital through monetary or contextual support for research, which contributes to their greater scientific productivity. As for students, this allows them, in particular, to gain practice, learn to apply theoretical knowledge in practice and respond to business needs.
Rancang Bangun Sistem Informasi Praktek Kerja Lapangan Berbasis Web pada Program Studi Teknik Informatika Jurusan Teknik Elektro Politeknik Negeri Pontianak
Authors: Siswanto Lindung , Sufandi Muhammad Ridwan , Suryanto Tommi , Atmojo Tri Bowo
Published: April 2022

Praktek Kerja Lapangan (PKL) merupakan salah satu mata kuliah yang ada pada Program Studi Teknik Informatika Jurusan Teknik Elektro Politeknik Negeri Pontianak lebih mengarahkan mahasiswa pada perilaku berkarya. Saat ini proses administrasi kegiatan PKL masih dilakukan secara manual, dengan adanya keterbatasan waktu dan sedang berlangsungnya penyebaran virus covid-19 (corona virus) menghimbau untuk menerapkan Social distancing dan physical distancing, maka proses manual tersebut tidak berjalan secara optimal, maka diperlukan sistem informasi praktek kerja lapangan untuk mengoptimalkan proses yang ada, sistem informasi dibuat berbasis web dengan menggunakan framework codeigniter dengan teknologi pendukung JSON, javascript dan Mysql sebagai Database Management System. Sistem informasi ini memiliki empat level user yaitu mahasiswa, dosen pembimbing PKL, koordinator dan jurusan. Sistem ini mampu melayani pengusulan lokasi PKL, cetak surat pengantar, penentuan dosen pembimbing, unduh berkas yang diperlukan pada saat PKL dilaksanakan, dan media konsultasi antara mahasiswa dengan dosen pembimbing untuk kelancaran pelaksanaan PKL secara online dan realtime.
Pemilihan Kabel Instalasi Listrik Untuk Bangunan Gedung Berdasarkan Kualitas Tahanan Isolasi
Authors: Irman Irman , Latifah Latifah , Ruskardi Ruskardi , Arief Muh Sulkhan
Published: April 2022

The building fire in Pontianak was the result of an electrical short circuit or an electric current, namely the connection between a live conductor and a neutral conductor. Where the electrical installation cables used are generally NYM and NYA cables.

NYM and NYA cables must be of good quality. This is related to the safety of buildings against fire hazards due to short circuits of electrical cables. For this reason, research is needed in the form of measuring cable insulation resistance to ensure the quality and feasibility of several cable brands on the local market in Pontianak.

Based on the measurement results on the five test samples, each cable NYM 3 x 2.5 mm2, NYM 2 x 2.5 mm2 and NYA 2.5 mm2, it was found that the NYM cable was 3 x 2.5 mm2 (sample A), NYM cable 2 x 2 .5 mm2 (Sample A) and 2.5 mm2 NYA Cable (sample B) have the highest insulation resistance of the cable sheath compared to 4 (four) other samples, namely 25,010 M Ohm (NYM 3 x 2.5 mm2), 25,425 M Ohm ( NYM 2 x 2.5 mm2) and 39,850 M.Ohm (NYA 2.5 mm2). This shows that these cables have a better quality of sheath insulation resistance than others. While the cables that have the smallest sheath insulation resistance are 11,014 M Ohm (Sample B NYM cable 3 x 2.5 mm2), 10,720 M Ohm (Sample B NYM cable 2 x 2.5 mm2) and 21,580 M.Ohm (Sample A NYA 2.5 mm2) cable.
Rancang Bangun Jaringan Internet Dan Intranet Untuk Mendukung Layanan Administrasi Dan Informasi Masyarakat
Authors: Arafat Yasir , Atmojo Tri Bowo , Faisal Ferry
Published: April 2022

Penelitian ini dilaksanakan dengan latar belakang rancang bangun infrastruktur jaringan internet dan intranet desa (studi kasus di desa Pemangkat Kota) yang saat penelitian ini dilakukan masih belum memiliki infrastruktur dimaksud.  Penelitian ini menitik beratkan pada topology jaringan internet dan intranet desa yang tepat dalam upaya mendukung layanan administrasi desa, layanan informasi desa dalam bentuk TV desa dan Web Desa serta penerapan pembelajaran E-learning bagi sekolah di lingkungan sekitar desa Pemangkat kota. Selain itu penelitian ini juga ingin mengetahui kebutuhan bandwidth yang optimal dalam proses komunikasi data pada jaringan internet dan intranet desa. Lebih lanjut, penelitian ini menganalisis kebutuhan perangkat jaringan ( Network device) minimize agar rancangan dapat bekerja secara optimal
Логическое моделирование динамики знаний
Authors: Козаченко Надія Павлівна
Published: April 2022

Спираючись на переконання у якості основного об’єкту дослідження, системи динамічної епістемічної логіки ставлять перед собою низку завдань: дослідити процес отримання і функціонування переконань; дослідити властивості переконань, що проявляються в процесі їхнього функціонування; встановити основні принципи, за якими здійснюється процес зміни переконань; розглянути основні пізнавальні операції, за допомогою яких відбувається процес зміни переконань; прояснити роль суб’єкта в процесі зміни переконань та інші.
Историческое знание и историческая действительность: в защиту "внутреннего реализма" (часть первая)
Authors: Лоренц Крис
Published: April 2022

В статье рассматривается одна из ключевых теоретико-познавательных проблем – проблема соотношения знания и действительности — в ее экспликации применительно к специфике исторического познания. Автор обосновывает концепцию«внутреннего реализма» для исторической науки и демонстрирует, каким образом эта концепция помогает преодолеть ограниченность подходов объективизма и релятивизма в интерпретации исторического знания. Вводится понятие «практический интерес истории», что позволяет рационально объяснить нормативное измерение истории и по-новому подойти к рассмотрению проблемы соотношения фактов и ценностей. Основные положения своей концепции автор иллюстрирует и обосновывает на материале так называемого Historikerstreit – известного спора немецких историков о характере и методах исторического исследования событий Второй мировой войны.
Динаміка «соціальних замовлень» та становлення гуманітаристики (на прикладі історичної науки)
Authors: Панафідіна Оксана Петрівна
Published: April 2022

У статті розглянуто процес становлення гуманітарних наук лід впливом «соціальних замовлень». Проаналізовано трансформацію методологічних засад історичної науки. Надано увагу ідеям існування законів та альтернативності в історії, а також ідеї завершення історичного процесу.
Відкрите суспільство, критичне мислення та раціональність
Authors: Абдула Андрій Іванович
Published: April 2022

Розглядається критико-раціоналістична традиція, пов’язана з просвітницькою вірою в розум (науковий, філософський, політичний, загальнолюдський), як така, що має єдине підґрунтя в усіх своїх проявах. Цим підґрунтям постає раціональна критика, соціальним проявом якої є «відкрите» (до критики) суспільство. Стверджується, що методологічні принципи, до яких апелює критико-раціоналістична традиція (критична настанова, плюралізм, егалітаризм, номіналізм, антифундаменталізм та ін.) зберігають значний гносеологічний потенціал, орієнтуючи, у тому числі, й на перспективу соціальних перетворень. Висвітлюються ключові аспекти цієї концепції, у зв’язку з категоріями «розуму», «критики», «критичного мислення». Звертаючись до трьох аспектів критичного мислення: психолого-педагогічного, логіко-методологічного та наукового, робиться висновок, що подібна інтерпретація у цілому відповідає уявленню про «критичний розум» (у тлумаченні К. Поппера). Підкреслюється, що критико-раціоналістична методологія апелює не лише до гуманістичних чи просвітницьких цінностей, але й до універсального способу розвитку – методу спроб і помилок. Аналізуються можливості попперівської концепції як методології соціальних реформ, а також проблемні аспекти методологічних засад критичного раціоналізму та безпосередньо «відкритого суспільства».
Многоаспектность знания как фактора развития общества
Authors: Брюховецький Микола Миколайович
Published: April 2022

В статье исследуется вопрос многоаспектной природы знания в контексте его рассмотрения как фактора развития общества. Делается вывод о существовании знания как фактора развития общества, по меньшей мере, в трех формах. В первой, субъективной форме знание, как состояния сознания, выступает субъективным духовным фактором общественного развития. Во второй, кодифицированной форме знание, как вид информации, в знаковом, символическом проявлении, предстает в роли бъективного духовного фактора. В третьей, материализованной форме знание как средства и другие элементы общественного производства, является материальным опосредствованным практикой актором развития общества.
Економічні закономірності та причини згортання НЕПу
Authors: Брюховецький Микола Миколайович
Published: April 2022

Розглядається минулий досвід економічної політики,епоха нової економічної політики 1921-1928 рр. Відображено позитивну роль в економіці, виходячи із економічних закономірностей, причини відмови більшовиків від НЕПу. Подано обʼєктивне тлумачення даного питання.
Проблема свідомості: феноменологічні грані
Authors: Балута Галина Анатоліївна
Published: April 2022

У статті розглядається дослідницька перспектива рефлексивно-феноменологічного аналізу свідомості як методологічної спроби поєднання рефлексивної та редукціоністської філософських традицій. Автор актуалізує темпоральні характеристики рефлексії на основі ідей Р. Декарта, А. Бергсона та Е. Гуссерля. Також автор критично оцінює недоліки біхевіоризму. Під час міркувань автор використовує низку релевантних аргументів британського математика Р. Пенроуза. Пенроуз розглядає проблему розуміння як вихідну проблему наукової теорії свідомості й аналізує свідомість як необчислюване явище.
До проблеми феноменологічного обґрунтування соціальних змістів професійної етики
Authors: Балута Галина Анатоліївна
Published: April 2022

На засадах феноменологічного підходу та принципів сучасного етичного дискурсу здійснюється спроба перегляду низки визначень професійної етики в контексті актуальних проблем соціальної етики і подається його оновлений інваріант.
Організація навчальної праці учнів у процесі виконання домашніх завдань
Authors: Буряк В. К.
Published: April 2022

У статті обґрунтовано оптимальну систему заходів у процесі виконання домашніх завдань, яка залежить від правильної організації в часі й черговості виконання завдань, а також чергування періодів роботи й відпочинку.
Підвищення ефективності педагогічної освіти як найважливіший чинник розвитку суспільства
Authors: Буряк В. К.
Published: April 2022

У статті розглянуто шляхи підвищення ефективності педагогічної освіти.
Урок в старших классах
Authors: Буряк В. К. , Беришвили Д. Д.
Published: April 2022

В пособии дается дидактический анализ различных типов уроков в старших классах, показаны условия повышения эффективности урока как организационной формы обучения, воспитания и развития учащихся. Рассмотрены основные пути и средства воспитания учащихся на уроке и раскрыты вопросы их развития в процессе проблемно-поисковой Деятельности, а так же развития у них познавательной самостоятельности и творческих способностей. Рассмотрены мотивы познавательной деятельности учащихся и самостоятельная их работа на уроке. Теоретические положения и выводы аргументируются примерами из передового опыта учителей естественно-математических дисциплин. Пособие предназначено для студентов университетов, педагогических институтов и слушателей факультетов повышения квалификации руководящих работников народного образования.
Художній світ української імпресіоністичної повісті 20-х років ХХ століття
Authors: Журба Світлана Степанівна
Published: April 2022

У монографії досліджується художній світ української імпресіоністичної повісті 20-хроків XX століття. Головну увагу приділено жанротворчим пошукам митців, інтертекстуальності та внутрішній дискусійності, літературознавчому аналізу творів А.Головка, Г.Косинки, М.Хвильового, Г.Михайличенка, В.Підмогильного, М.Івченка, М.Ірчана, О.Туринського, В.Яновського. Повість розглядається як цілісна структура в плані вивчення домінуючих ознак її поетики, концепції героя, структури тексту (сюжет, композиція, конфлікт, часово-просторові координати). Призначається для викладачів та студентів філологічних факультс тів, вчителів-словесників.
Day of Dialogue on Contraceptive Methods for Today and Tomorrow: Developments, Prospects, and Issues
Authors:   Population Council
Published: April 2022

This “aide-memoire” records the substance of the presentations and discussions of a Day of Dialogue—spanning two half-days on June 20–21, 1994—among representatives of the European donor community and the Population Council on “Contraceptive Methods for Today and Tomorrow: Developments, Prospects, and Issues.” The discussion covered how contraceptives are developed, prospects for new technology, areas of controversy surrounding current and potential methods, and ways to improve the process. This is the third Day of Dialogue the Population Council has been instrumental in organizing. The format for these meetings is simple and informal: Population Council staff and invited experts from other organizations give brief presentations. This is followed by far-ranging discussions over the course of the day. By design, no consensus is reached or set of recommendations circulated. An aide-memoire sent to all participants is the meeting’s record of comments, proposals, and suggestions for follow-up action. The June 20–21 participants saw the dialogue as a mechanism to elucidate for European donors some of the important issues to be discussed at the International Conference on Population and Development in Cairo in September 1994, and other upcoming international meetings.