bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between lexical, reading and spelling skills in bilingual language minority children and their monolingual peers
Authors: Vettori Giulia , Incognito Oriana , Bigozzi Lucia , Pinto Giuliana
Published: August 2023

This study was conducted on a population of primary school children including bilingual language minority (BLM) children with L2-Italian and a variety of languages as L1 (e.g., Chinese, Albanian, Latin), and Italian-speaking monolingual children. The variety of languages ecologically reflects the nowadays composition of classes in the Italian school system. The aims were to investigate in both linguistic groups: (1) the developmental patterns of lexical, reading and spelling skills; (2) the pattern of predictive relations between lexical, reading and spelling skills. 159 primary school children from Grade 2 to Grade 5 participated in the study: BLM (n = 80) and monolingual (n = 79) children aged between 7 and 11 years. Each participant completed a vocabulary task (lexical skills), a text reading task (reading accuracy and reading speed) and a text dictation task (orthographic errors). ANOVA statistics showed the comparison of patterns between monolingual and BLM children in lexical, reading, and writing skills. Results show lower performances in lexical, reading and spelling skills in BLM children learning Italian as a second language compared to monolingual peers. Second, partial correlations performed separately for monolinguals and BLM with lexical ability as a control variable, illustrated that all variables correlated with each other in both groups. This result provides the option of performing hierarchical regressions. Finally, hierarchical regression analyses showed that the pattern of predictive relations between lexical, reading and spelling skills is the same across language groups, with the key role of orthographic accuracy as the pivotal process around which reading and lexical skills are built.
Profiles of parents’ emotion socialization within a multinational sample of parents
Authors: King Gabriella L. , Macdonald Jacqui A. , Greenwood Christopher J. , Kehoe Christiane , Dunsmore Julie C. , Havighurst Sophie S. , Youssef George J. , Berkowitz Tomer S. , Westrupp Elizabeth M.
Published: August 2023

Introduction

Seminal emotion socialization theories classify parents according to two patterns of parent emotion socialization processes: ‘emotion coaching’ (i.e., parents validate and teach children about emotions) versus ‘emotion dismissing’ parenting (i.e., parents minimize and dismiss their children’s emotions). However, empirical evidence supporting this binary distinction of parents remains limited. Our objective was to investigate whether parents can be differentiated by distinct patterns in their (1) beliefs about children’s emotions, (2) emotion regulation, and (3) emotion-related parenting practices.

Method

Participants were parents of children aged 4–10 years from the Child and Parent Emotion Study (N = 869) (https://bmjopen.bmj.com/content/10/10/e038124). Parents completed self-reported measures of emotion socialization processes via an online survey, which took 20–30 min to complete. Data included in the current study were collected May–August 2019. We conducted a latent profile analysis of parents’ emotion socialization (13 indicators). To assess reliability of the profiles, we examined stability of the profiles across (1) parents of children in early versus middle childhood, and (2) fathers versus mothers, via measurement invariance testing. Further, to assess for construct validity of the profiles, we examined concurrent associations between six criterion constructs and parents’ emotion socialization profiles.

Results

A three-profile model emerged characterizing parents by: (1) emotion coaching; (2) emotion dismissing; (3) emotion disengaged. There was strong support for construct validity and reliability.

Discussion

Our study provides empirical support for distinct differentiated classifications of emotion coaching and emotion dismissing parenting, aligned with emotion socialization theories. We further extend on extant theory and suggest a third ‘emotion disengaged’ classification, describing parents with moderate levels of emotion dismissing parenting and low levels of emotion coaching parenting. It should be noted that the profiles were derived with self-report data, therefore, data may have been biased by contextual factors. Furthermore, the study sample consisted of Western families from affluent backgrounds. The field should focus efforts on conducting person-centered studies with more diverse samples in future.
The perceived value of local knowledge tourism: dimension identification and scale development
Authors: Zhang Hailin , Jiang Jinbo , Zhu Jinsheng (Jason)
Published: August 2023

Introduction

Local knowledge tourism encompasses the rich cultural heritage, historical narratives, and traditional practices of a specific destination. Despite its significance in enhancing the tourist experience, there is a dearth of research examining the subjective perceptions and values of visitors engaging in local knowledge tourism. Consequently, there is a pressing need to explore the composition of perceived tourist values in this unique context.

Methods

Due to the exploratory nature of this research, a constructivist grounded theory and content analysis are applied to analyze the data.

Results

This study identifies and conceptualizes five distinct dimensions of perceived values in local knowledge tourism: functional value, emotional value, social value, cognitive value, and self-actualization value. Furthermore, an 18-item scale is developed to measure these dimensions quantitatively.

Discussion

This research makes several significant contributions: (1) it expands the scope of perceived value research within the tourism domain and enhances our understanding of the tourist experience in local knowledge tourism; (2) it provides a reliable instrument for future quantitative investigations into the behavior and mindset of local knowledge tourists; and (3) it offers theoretical foundations and practical insights for destination managers seeking to develop tourism products tailored to the preferences and expectations of local knowledge tourists.
Measuring PERMA+4: validation of the German version of the Positive Functioning at Work Scale
Authors: Lorenz Timo , Ho Janika , Beyer Marla , Hagitte Leonie
Published: August 2023

This study investigates the association between the PERMA+4 model and psychological safety, while also examining the validation of the Positive Functioning at Work (PFW) scale in a German-speaking population. The study discovered strong association between PERMA+4 and psychological safety, which raises important questions and potential concerns regarding the jangle fallacy. Similar to the PERMA model, PERMA+4 should be considered a framework for attaining psychological safety. The German version of the PFW scale demonstrated satisfactory fit with the model, indicating its factorial validity. To gain insights into promoting workplace wellbeing, it is recommended to conduct longitudinal studies to determine whether psychological safety is a cause or result of PERMA+4. This study enhances our understanding of workplace wellbeing and emphasizes the association between PERMA+4 and psychological safety.
A high propensity for excessive daytime sleepiness independent of lifestyle is associated with cognitive performance in community-dwelling older adults
Authors: Wu Junxin , Wu Zijing , Xie Caixia , Lin Yongsheng , Fu Zhiqiang , Zhu Limao , Qi Wei , Wang Huali
Published: August 2023

Objective

The relationship between excessive daytime sleepiness (EDS) and cognitive performance of older adults remains unclear, especially when a healthy lifestyle is considered. The study aimed to explore the association between EDS in passive and active situations and general cognitive function among community-dwelling older adults.

Methods

Two hundred and seventy-one older adults aged 60 and above were recruited from the community cohort in Shangrao. All study participants were free of depression and dementia. The Chinese version of the Epworth Sleepiness Scale (CESS) was used to evaluate EDS. Using the item scores of CESS, the presence of EDS among all study participants were grouped as non-EDS, passive situation-related EDS (PSR-EDS), active situation-related EDS (ASR-EDS), and high sleep propensity (HSP). The Hong Kong Brief Cognitive Test (HKBC) was used to assess cognitive function. Chinese healthy lifestyle metrics were scored based on AHA Life Simple-7. The multivariate logistic regression model was used to estimate the association between the presence of EDS and cognitive function.

Results

The PSR-EDS (n = 29, 20.8 ± 5.3) and the HSP groups (n = 21, 19.8 ± 4.8) scored lower with HKBC than in the non-EDS group (n = 213, 23.2 ± 4.9). The subdomain performance of language in the HSP group was poorer than in the non-EDS group (ps < 0.05). Relative to non-EDS, HSP (OR = 3.848, 95% CI = 1.398-10.591) was associated with an increased risk of poor cognitive performance after adjusting age, sex, education, and healthy lifestyle metrics.

Conclusion

High propensity for excessive daytime sleepiness, irrespective of lifestyle, is associated with poorer cognitive performance among community-dwelling older adults. The findings may provide empirical evidence to support sleepiness intervention for reducing the risk of cognitive decline.
Treatment without consent in adult psychiatry inpatient units: a retrospective study on predictive factors
Authors: Meroni Giulia , Sentissi Othman , Kaiser Stefan , Wullschleger Alexandre
Published: August 2023

Background

Coercion is one of the most important challenges in mental health. In Switzerland, forced medication can be applied during an emergency (Art. 435 of the Civil Code) or over a longer period in case of endangerment of others or oneself (Art. 434). We aimed to analyze the predictors of this specific treatment without consent.

Methods

Forced medication prescriptions in the Division of Adult Psychiatry of the Geneva University Hospitals between 2018 and 2021 were retrospectively analyzed. Medication under Article 434 was the main outcome variable. Age, gender, admission mode, main diagnosis, and the Health of the Nation Outcome Scales (HoNOS) score at admission were considered as potential predictors. T-test and Pearson’s chi-square test were used to compare continuous and categorical variables. A logistic regression was performed to find significant predictors of forced medication.

Results

Seventy-one out of 4,326 inpatients were subjected to forced medication under Art. 434. HoNOS global scores at admission were not significantly different in the forced medication group compared to the control group. Aggressive behavior was lower in the former at the univariate level. Forced medication was associated at the multivariate level with female gender, involuntary admission, and psychosis.

Conclusion

Women suffering from psychosis are more at risk of receiving involuntary and repeated medication. The risk of deterioration in psychosocial functioning or behavioral disorganization seems to be the main argument for this coercive measure. Future studies should focus on the patient’s perception of this coercion to prevent it and improve adherence to care. Follow-up after discharge might be useful to evaluate a long-term benefit.
Disability and other identities?—how do they intersect?
Authors: Wickenden Mary
Published: August 2023

This paper addresses intersectionality and disability in global contexts. Disability as a category of identity is often omitted in rhetoric about intersectionality, which usually considers race and gender, with some consideration of other identities. However, disability like other identities is socially constructed, and liable to misrepresentation and is often siloed from other issues and experiences. Someone identifying as disabled may not be recognised by those around them as having other identities too. In discussions about intersectionality, a simplistic “additive” approach is common, while the shifting complexities and interactions between people's multiple identities are not considered with nuance. Disabled people may pragmatically adopt a kind of “strategic essentialism”. This allows them to claim a disabled identity and a specific dialogic space in order to gain recognition and perhaps access to support and services. However, they may prefer not to be classified in this dichotomised way because this ignores other aspects of them. Often an impairment is only of importance to the extent that it means that the person needs some reasonable adjustments in order to participate on equal basis with others. Arguably the SDGs and other global guidelines and treaties do not address disability as a significant identity sufficiently, nor recognise it as an important aspect of many people in combination with their other identities, rather than a stand-alone feature of them. When analysing the types of disadvantages that people experience, a broader more flexible approach is needed which recognises the ways in which different identities combine and influence people's experiences.
The link between immune thrombocytopenia and the cytokine profile: a bridge to new therapeutical targets
Authors: Andreescu Mihaela
Published: August 2023

Immune thrombocytopenia (ITP) manifests as depleted platelet reserves, primarily due to the immune-mediated destruction of platelets. The pathogenesis of ITP is complex and involves dysregulation of the immune system. This review aimed to summarize the current knowledge of the cytokine profile in ITP and its potential implications for diagnosis, treatment, and prognosis. Several studies have reported that ITP patients have an altered cytokine profile from that of healthy individuals. Specifically, there is evidence of an imbalance of pro-inflammatory (interleukin (IL)-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ) and anti-inflammatory cytokines (IL-10, TGF-β). The cytokine profile in ITP appears to be heterogeneous, with different patterns observed in different subsets of patients. For example, some studies have reported a Th1-type cytokine profile, characterized by elevated levels of IFN-γ and TNF-α, while others have reported a Th2-type cytokine profile, characterized by elevated levels of IL-4 and IL-10. There is also evidence of a shift from a Th1 to a Th2 cytokine profile in some patients over time. The cytokine profile in ITP may have important implications for diagnosis, treatment, and prognosis. Targeting specific cytokines or cytokine pathways may also represent a promising therapeutic approach for ITP. Further studies are needed to better understand the heterogeneity of the cytokine profile in ITP and its potential implications for clinical management.
Exploring alternative marine lipid sources as substitutes for fish oil in Farmed Sea bass (Dicentrarchus labrax) and their influence on organoleptic, chemical, and nutritional properties during cold storage
Authors: Filipa-Silva Andreia , Marques Alexandra , Salgado Maria Antónia , Abreu Helena , Dias Jorge , Valente Luisa M. P.
Published: August 2023

This study evaluated the replacement of fish oil (sardine oil) by different combinations of alternative marine lipid ingredients as sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in European sea bass (Dicentrarchus labrax) throughout 14 days of ice storage. A practical diet (SARDINE) was used as a control, which included 9% sardine oil and 4.4% soybean oil, providing 2.3% of EPA + DHA. Two other experimental diets were formulated to achieve the same EPA + DHA values but completely devoid of soybean oil. In the ALGABLEND diet, 6.7% of salmon oil (salmon by-product) and 2% of algae biomass (Algaessence Feed™) partially replaced sardine oil. In the ALGAOIL diet, sardine oil was totally replaced with 10.1% salmon by-product oil and 3.3% algae oil (Veramaris®). All diets were equally well-accepted by European sea bass, resulting in similar growth performance, somatic indexes, and whole body composition. At the end of the trial, no significant differences were found in the EPA + DHA levels of fish muscle between dietary treatments, resulting in high values of EPA + DHA (> 0.62 g 100 g−1). Furthermore, replacing fish oil did not significantly affect the organoleptic and chemical properties of the fish samples. Parameters such as pH, water holding capacity, lipid oxidation, antioxidant capacity, color and texture presented similar values to those obtained for fish fed the SARDINE diet during the 14 days of storage in ice. In conclusion, these results show that combining algal oil (Veramaris®), algae blend (Algaessence Feed™) and salmon by-product oil can be a successful strategy for the fortification of European sea bass muscle in EPA and DHA while ensuring fish freshness, nutritional quality, and consumers’ health.
Development of a fixed list of descriptors for the qualitative behavioral assessment of thoroughbred horses in the racing environment
Authors: Jaramillo Fernando Mosquera , Oliveira Tiago Marcelo , Silva Pedro Enrique Ayres , Trindade Pedro Henrique Esteves , Baccarin Raquel Yvonne Arantes
Published: August 2023

Introduction

Horse racing is a major sport practiced worldwide. The environment to which horses are exposed during race meetings can influence their behavior. However, to the best of our knowledge, a method for assessing a horse’s response to its surroundings during the pre- and post-race periods has not yet been reported. This study aimed to create a standard list of descriptors for use in a qualitative behavioral assessment (QBA) focused on assessing the emotional expressivity of horses before and after racing events.

Materials and methods

Seventy pre- or post-race 30-second videos of horses were randomly selected from our database of 700 videos. A panel of 8 experienced equine sports medicine specialist veterinarians watched a 60 min presentation on QBA. The panel then watched all videos randomly, simultaneously, individually, continuously, and without any verbal interaction, describing the descriptors related to the emotional expressivity of the horse after each video using a method known as free-choice profiling (FCP).

Results

The initial selection of descriptors was based on those indicated by more than one evaluator in the same video, or descriptors with more than 20 occurrences. The second selection was performed based on the content validity index (CVR) to select the descriptors retained in the previous step. Another panel of six veterinarians scored each of the descriptors retained for content validity on a visual scale. Interobserver reliability was estimated using the intraclass correlation coefficient (ICC) and its respective 95% confidence intervals (CI). A natural language processing (NLP) algorithm was used to analyze the behavior (positive or negative polarity) of the descriptors based on the lexicoPT package of R software.

Discussion/Conclusion

NLP analysis considered the descriptors “agitated,” “troubled,” “restless” and “irritated” to have a negative polarity, while “focused,” “relaxed” and “peaceful” had a positive polarity. In the principal component analysis (PCA), descriptors in a negative state were associated with each other and inversely associated with descriptors in a positive state. We conclude with a fixed list of descriptors to be used in a QBA to assess emotional and welfare expressivity in racehorses’ pre- and post-race environments.
The kinetics of glutathione in the gastrointestinal tract of weaned piglets supplemented with different doses of dietary reduced glutathione
Authors: Hou Yuhuang , Michiels Joris , Kerschaver Céline V. , Vandaele Mario , Majdeddin Maryam , Vossen Els , Degroote Jeroen
Published: August 2023

This study aimed to investigate the kinetics of dietary GSH in the gastrointestinal tract and the effect of GSH on the intestinal redox status of weaned piglets. Forty-eight piglets with an average age of 26 days and an average body weight of 7.7 kg were used in this study. The piglets were divided into three treatment groups including the control group with a basal diet (CON) and two GSH groups with a basal diet supplemented with 0.1% GSH (LGSH) and 1.0% GSH (HGSH), respectively. The basal diet did not contain any GSH. The experiment lasted for 14 days, with eight animals sampled from each group on d5 and 14. The parts of 0–5%, 5–75%, and 75–100% of the length of the small intestine were assigned to SI1, SI2, and SI3. The results showed that GSH almost completely disappeared from the digesta at SI2. However, no difference in the GSH level in mucosa, liver, and blood erythrocytes was found. The level of cysteine (CYS) in SI1 digesta was significantly higher in HGSH than CON and LGSH on d14, and similar findings were observed for cystine (CYSS) in SI3 digesta on d5. The CYSS level in HGSH was also significantly higher than LGSH in the stomach on d14, while no CYS or CYSS was detected in the stomach for control animals, indicating the breakdown of GSH to CYS already occurred in the stomach. Irrespective of the dietary treatment, the CYS level on d14 and the CYSS level on d5 and 14 were increased when moving more distally into the gastrointestinal tract. Furthermore, the mucosal CYS level was significantly increased at SI1 in the LGSH and HGSH group compared with CON on d5. Glutathione disulfide (GSSG) was recovered in the diets and digesta from the LGSH and HGSH group, which could demonstrate the auto-oxidation of GSH. It is, therefore, concluded that GSH supplementation could not increase the small intestinal mucosal GSH level of weaned piglets, and this could potentially relate to the kinetics of GSH in the digestive tract, where GSH seemed to be prone to the breakdown to CYS and CYSS and the auto-oxidation to GSSG.
Multiplex digital PCR: a superior technique to qPCR for the simultaneous detection of duck Tembusu virus, duck circovirus, and new duck reovirus
Authors: Yin Yanwen , Xiong Chenyong , Shi Kaichuang , Long Feng , Feng Shuping , Qu Sujie , Lu Wenjun , Huang Meizhi , Lin Changhua , Sun Wenchao , Li Zongqiang
Published: August 2023

Duck Tembusu virus (DTMUV), duck circovirus (DuCV), and new duck reovirus (NDRV) have seriously hindered the development of the poultry industry in China. To detect the three pathogens simultaneously, a multiplex digital PCR (dPCR) was developed and compared with multiplex qPCR in this study. The multiplex dPCR was able to specifically detect DTMUV, DuCV, and NDRV but not amplify Muscovy duck reovirus (MDRV), Muscovy duck parvovirus (MDPV), goose parvovirus (GPV), H4 avian influenza virus (H4 AIV), H6 avian influenza virus (H6 AIV), and Newcastle disease virus (NDV). The standard curves showed excellent linearity in multiplex dPCR and qPCR and were positively correlated. The sensitivity results showed that the lowest detection limit of multiplex dPCR was 1.3 copies/μL, which was 10 times higher than that of multiplex qPCR. The reproducibility results showed that the intra- and interassay coefficients of variation were 0.06–1.94%. A total of 173 clinical samples were tested to assess the usefulness of the method; the positive detection rates for DTMUV, DuCV, and NDRV were 18.5, 29.5, and 14.5%, respectively, which were approximately 4% higher than those of multiplex qPCR, and the kappa values for the clinical detection results of multiplex dPCR and qPCR were 0.85, 0.89, and 0.86, indicating that the two methods were in excellent agreement.
Bacterial culture and antimicrobial susceptibility results from bovine milk samples submitted to four veterinary diagnostic laboratories in Australia from 2015 to 2019
Authors: Langhorne Charlotte , Gupta Suman Das , Horsman Sara , Wood Caitlin , Wood Benjamin J. , Barker Leslie , Deutscher Ania , Price Rochelle , McGowan Michael R. , Humphris Mark , Ranjbar Shahab , Henning Joerg , Gibson Justine S.
Published: August 2023

A 5-year retrospective study was conducted to describe the mastitis-causing organisms isolated from bovine milk samples submitted to four veterinary diagnostic laboratories in Australia. The aim of this study was to identify temporal, geographical, and seasonal patterns of occurrence for the organisms and report the in vitro susceptibility of the most common mastitis-causing pathogens. In total, 22,102 milk samples were submitted between 2015 and 2019. The results were reported as positive growth for at least one significant organism (n = 11,407; 51.6%), no growth (n = 5,782; 26.2%), and mixed/contaminated growth (n = 4,913; 22.2%). Culture results for no growth, gram-negative bacteria, and eukaryotic organisms were combined for each region, and they were accounted for between 23 and 46% of submissions. These results represent a subset of mastitis cases for which the antibiotic treatment may not be warranted. A total of 11,907 isolates were cultured from 11,407 milk samples. The most common isolated organisms were Streptococcus uberis [41.3%; 95% confidence interval (CI): 40.4–42.1%] and Staphylococcus aureus (23.6%; 95% CI: 22.8–24.3%). For S. uberis and S. aureus, there was an association between a positive culture result and the dairy region. All regions except for the Sub-tropical Dairy region were more likely to culture S. uberis compared to the reference, Dairy NSW (P < 0.001). Similarly, for S. aureus, a positive culture result was more likely in all other dairy regions compared to Dairy NSW (P < 0.001). The LISA cluster analysis identified differences between High-High (hotspot) postcodes for S. aureus and S. uberis throughout all the analyzed dairy regions. These results highlight the need for further investigations into specific risk factors, such as environmental factors and herd-level predictors, which may have influenced the observed regional variations. Common mastitis-causing pathogens showed overall good susceptibility to a range of antimicrobials used in the treatment of mastitis. On-going surveillance of mastitis-causing pathogens and their antimicrobial susceptibilities will facilitate targeted mastitis control and treatment programs.
Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Authors: Tie Wenting , Ma Tao , Yi Zhigang , Liu Jia , Li Yanhong , Bai Jun , Li Lijuan , Zhang Liansheng
Published: August 2023

Multiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements. In this review, we summarize the epidemiologic studies to show that the risk of MM is increased in obese. Accumulating clinical evidence suggests that adipokines could display a correlation with MM. In vitro and in vivo studies have shown that adipokines are linked to MM, including roles in the biological behavior of MM cells, cancer-associated bone loss, the progression of MM, and drug resistance. Current and potential therapeutic strategies targeted to adipokines are discussed, proposing that adipokines can guide early patient diagnosis and treatment.
Reinforcement Learning Derived High-Alpha Aerobatic Manoeuvres for Fixed Wing Operation in Confined Spaces
Authors: Clarke Robert , Fletcher Liam , East Sebastian , Richardson Thomas
Published: August 2023

Reinforcement learning has been used on a variety of control tasks for drones, including, in previous work at the University of Bristol, on perching manoeuvres with sweep-wing aircraft. In this paper, a new aircraft model is presented representing flight up to very high angles of attack where the aerodynamic models are highly nonlinear. The model is employed to develop high-alpha manoeuvres, using reinforcement learning to exploit the nonlinearities at the edge of the flight envelope, enabling fixed-wing operations in tightly confined spaces. Training networks for multiple manoeuvres is also demonstrated. The approach is shown to generate controllers that take full advantage of the aircraft capability. It is suggested that a combination of these neural network-based controllers, together with classical model predictive control, could be used to operate efficiently within the low alpha flight regime and, yet, respond rapidly in confined spaces where high alpha, agile manoeuvres are required.
Income and Asset Situation of Companies Producing Arable Crops in the Visegrad Countries
Authors: Szőllősi László , Erdős Adél Dorottya
Published: August 2023

The V4 countries (Poland, Slovakia, Czechia, Hungary) hold significant importance within the European Union, contributing nearly 20% of the EU’s arable land and 10% of its crop output from 2018 to 2020. The study focuses on companies as organizational entities engaged in arable crop production, representing a specific segment of agricultural producers. The objective is to analyze the concentration and financial performance of these companies in the V4 countries during the period 2018–2020. Financial data from 822 companies in Hungary, 226 in Slovakia, 17 in Czechia, and 967 in Poland were processed from the EMIS database (Emerging Market Information System). In Poland and Czechia, a significant proportion of the companies were classified as micro-enterprises, while in Hungary and Slovakia, they were predominantly small farms. The Gini index indicates a high concentration of Polish farms, a medium concentration of Hungarian and Slovakian farms, and a low concentration of Czech companies. In terms of financial profitability, Hungarian and Polish companies are the most favorable, while Slovak farms are the least favorable. Polish companies exhibit significant heterogeneity, which may also be attributed to high concentration. The results suggest that higher financial profitability is associated with a lower debt rate in the capital structure. Based on the examined sample, there is no close relationship between farm size and financial efficiency in the case of companies engaged in arable crop production in the V4 countries. This study also found that as farm size increases, the profit (EBIT) tends to increase, but the magnitude of this effect varies among the companies in different countries. The study’s findings also support that other factors play a role in the development of profitability.
Design of Hydrostatic Power Shift Compound Drive System for Cotton Picker Experiment
Authors: Chen Huajun , Wang Meng , Ni Xiangdong , Cai Wenqing , Zhong Chunfa , Ye Haoyun , Zhao Yongqiang , Pan Wenlong , Lin Yuangang
Published: August 2023

To meet the working performance demand of cotton pickers, a hydrostatic power shift composite drive system design is proposed. This study aims to enhance the driving function of the cotton picker in various working conditions and improve its adaptability by combining a hydrostatic speed control system with a mechanical power shift structure. To achieve this, a single variable pump + double variable motor closed circuit is adopted. By adjusting the pump and motor displacement in stages, the driving speed of the cotton picker can be optimized for different working conditions. Additionally, the power shift mechanism is employed to increase the speed range and improve the transmission efficiency, enabling higher speeds to be achieved. Firstly, the main components of the composite drive system were calculated and selected, and then AMESim software was used for modeling and simulation analysis, and the results are as follows: When the cotton picker starts and picking operation stage variable displacement pump + fixed displacement dual motor speed control, the highest driving speed is 8.5 km/h. During the field and road transport operation stage fixed displacement pump + variable displacement dual motor speed regulation, the highest speed of 14.5 km/h was achieved in the field. When transferring to the road, the instant mechanical power shift speed and, the highest speed on the road was up to 27.5 km/h. Finally, the field experiment and speed ratio analysis of the drive system was conducted, and the average error of the experimental speed measurement was 0.588%. The speed ratio matching was in line with the design expectation. The results show that the hydrostatic power shift composite drive system designed in this study has good driving adaptability and can effectively meet the functions of cotton picker field picking, transport operation and road transportation in transit, which provides theoretical support for the design of cotton picker chassis drive system.
Determination of Characteristics and Establishment of Discrete Element Model for Whole Rice Plant
Authors: Xu Changsu , Xu Fudong , Tang Han , Wang Jinwu
Published: August 2023

In order to accurately establish a discrete element model for the whole plant flexibility of upright rice during the harvesting period, several physical characteristics, such as geometric features, moisture content, and density, of the entire rice plant were measured, along with frictional properties, such as the static and rolling friction coefficients, and mechanical properties, including the elastic modulus and restitution coefficient. A flexible and upright discrete element model of the rice plant was established using the DEM method based on the Hertz–Mindlin (no slip) and Hertz–Mindlin with bonding mechanical models. The parameters were optimized through Plackett–Burman screening experiments, steepest ascent experiments, and Box–Behnken optimization experiments to accurately determine the discrete element model parameters of each component of the rice plant. The calibration process of the contact parameters between rice grains and steel was analyzed in detail as an example, resulting in a calibration error of 0.68% for the natural repose angle. Taking the calibration of the contact parameters between the main stem and steel as an example, a detailed analysis of the calibration process was conducted. The calibration resulted in a calibration error of 2.76% for the natural repose angle and 2.33% for deflection. This study lays the foundation for understanding the mechanical response of rice and machinery when they are coupled together. Additionally, it provides valuable references for establishing discrete element models of plant species other than rice.
The Management of Neonates ≥34 Weeks’ Gestation at Risk of Early Onset Sepsis: A Pilot Study
Authors: Barbini Maria Cristina , Perniciaro Simona , Bresesti Ilia , Folgori Laura , Barcellini Lucia , Bossi Angela , Agosti Massimo
Published: August 2023

Early onset sepsis (EOS) is a potentially fatal condition in neonates, and its correct management is still challenging for neonatologists. Early antibiotic administration in the neonatal period may carry short- and long-term risks. Neonatal EOS calculator has been recently introduced as a new strategy to manage infants at risk of sepsis, and has shown promising results. Methods: In this single-center observational retrospective study, 1000 neonates ≥ 34 weeks’ gestation were enrolled with the aim to evaluate our standard protocol for the management of suspected EOS compared to the EOS calculator. Outcome measures included the following: (1) incidence of EOS and (2) proportion of infants in need of sepsis evaluations and antibiotics using our standard protocol versus theoretical application of EOS calculator. Results: A total of 223/1000 infants underwent blood investigations versus 35/1000 (3.5%) if EOS calculator had been applied (p < 0.0001; k = 0.18). Furthermore, 48/1000 infants received antibiotics with our protocol versus 35/1000 with EOS calculator (p = 0.12; k = 0.58). Three infants had a positive blood culture that EOS calculator would have missed. Conclusions: In our study, EOS calculator could have reduced investigations but not antibiotic therapy. EOS calculator is an effective and promising tool, but further studies are required to improve it.
Bacteriophage Therapy to Control Bovine Mastitis: A Review
Authors: Nale Janet Y. , McEwan Neil R.
Published: August 2023

Bovine mastitis is a polymicrobial disease characterised by inflammation of the udders of dairy and beef cattle. The infection has huge implications to health and welfare of animals, impacting milk and beef production and costing up to EUR 32 billion annually to the dairy industry, globally. Bacterial communities associated with the disease include representative species from Staphylococcus, Streptococcus, Enterococcus, Actinomyces, Aerococcus, Escherichia, Klebsiella and Proteus. Conventional treatment relies on antibiotics, but antimicrobial resistance, declining antibiotic innovations and biofilm production negatively impact therapeutic efficacy. Bacteriophages (phages) are viruses which effectively target and lyse bacteria with extreme specificity and can be a valuable supplement or replacement to antibiotics for bovine mastitis. In this review, we provide an overview of the etiology of bovine mastitis, the advantages of phage therapy over chemical antibiotics for the strains and research work conducted in the area in various model systems to support phage deployment in the dairy industry. We emphasise work on phage isolation procedures from samples obtained from mastitic and non-mastitic sources, characterisation and efficacy testing of single and multiple phages as standalone treatments or adjuncts to probiotics in various in vitro, ex vivo and in vivo bovine mastitis infection models. Furthermore, we highlight the areas where improvements can be made with focus on phage cocktail optimisation, formulation, and genetic engineering to improve delivery, stability, efficacy, and safety in cattle. Phage therapy is becoming more attractive in clinical medicine and agriculture and thus, could mitigate the impending catastrophe of antimicrobial resistance in the dairy sector.
NAC Pre-Administration Prevents Cardiac Mitochondrial Bioenergetics, Dynamics, Biogenesis, and Redox Alteration in Folic Acid-AKI-Induced Cardio-Renal Syndrome Type 3
Authors: Cuevas-López Belén , Romero-Ramirez Edgar Ignacio , García-Arroyo Fernando E. , Tapia Edilia , León-Contreras Juan Carlos , Silva-Palacios Alejandro , Roldán Francisco-Javier , Campos Omar Noel Medina , Hernandez-Esquivel Luz , Marín-Hernández Alvaro , Gonzaga-Sánchez José Guillermo , Hernández-Pando Rogelio , Pedraza-Chaverri José , Sánchez-Lozada Laura Gabriela , Aparicio-Trejo Omar Emiliano
Published: August 2023

The incidence of kidney disease is increasing worldwide. Acute kidney injury (AKI) can strongly favor cardio-renal syndrome (CRS) type 3 development. However, the mechanism involved in CRS development is not entirely understood. In this sense, mitochondrial impairment in both organs has become a central axis in CRS physiopathology. This study aimed to elucidate the molecular mechanisms associated with cardiac mitochondrial impairment and its role in CRS development in the folic acid-induced AKI (FA-AKI) model. Our results showed that 48 h after FA-AKI, the administration of N-acetyl-cysteine (NAC), a mitochondrial glutathione regulator, prevented the early increase in inflammatory and cell death markers and oxidative stress in the heart. This was associated with the ability of NAC to protect heart mitochondrial bioenergetics, principally oxidative phosphorylation (OXPHOS) and membrane potential, through complex I activity and the preservation of glutathione balance, thus preventing mitochondrial dynamics shifting to fission and the decreases in mitochondrial biogenesis and mass. Our data show, for the first time, that mitochondrial bioenergetics impairment plays a critical role in the mechanism that leads to heart damage. Furthermore, NAC heart mitochondrial preservation during an AKI event can be a valuable strategy to prevent CRS type 3 development.
Mitochondrial Dysfunction in Repeat Expansion Diseases
Authors: Giménez-Bejarano Alberto , Alegre-Cortés Eva , Yakhine-Diop Sokhna M. S. , Gómez-Suaga Patricia , Fuentes José M.
Published: August 2023

Repeat expansion diseases are a group of neuromuscular and neurodegenerative disorders characterized by expansions of several successive repeated DNA sequences. Currently, more than 50 repeat expansion diseases have been described. These disorders involve diverse pathogenic mechanisms, including loss-of-function mechanisms, toxicity associated with repeat RNA, or repeat-associated non-ATG (RAN) products, resulting in impairments of cellular processes and damaged organelles. Mitochondria, double membrane organelles, play a crucial role in cell energy production, metabolic processes, calcium regulation, redox balance, and apoptosis regulation. Its dysfunction has been implicated in the pathogenesis of repeat expansion diseases. In this review, we provide an overview of the signaling pathways or proteins involved in mitochondrial functioning described in these disorders. The focus of this review will be on the analysis of published data related to three representative repeat expansion diseases: Huntington’s disease, C9orf72-frontotemporal dementia/amyotrophic lateral sclerosis, and myotonic dystrophy type 1. We will discuss the common effects observed in all three repeat expansion disorders and their differences. Additionally, we will address the current gaps in knowledge and propose possible new lines of research. Importantly, this group of disorders exhibit alterations in mitochondrial dynamics and biogenesis, with specific proteins involved in these processes having been identified. Understanding the underlying mechanisms of mitochondrial alterations in these disorders can potentially lead to the development of neuroprotective strategies.
Perivascular Adipose Tissue Oxidative Stress in Obesity
Authors: Man Andy W. C. , Zhou Yawen , Xia Ning , Li Huige
Published: August 2023

Perivascular adipose tissue (PVAT) adheres to most systemic blood vessels in the body. Healthy PVAT exerts anticontractile effects on blood vessels and further protects against cardiovascular and metabolic diseases. Healthy PVAT regulates vascular homeostasis via secreting an array of adipokine, hormones, and growth factors. Normally, homeostatic reactive oxygen species (ROS) in PVAT act as secondary messengers in various signalling pathways and contribute to vascular tone regulation. Excessive ROS are eliminated by the antioxidant defence system in PVAT. Oxidative stress occurs when the production of ROS exceeds the endogenous antioxidant defence, leading to a redox imbalance. Oxidative stress is a pivotal pathophysiological process in cardiovascular and metabolic complications. In obesity, PVAT becomes dysfunctional and exerts detrimental effects on the blood vessels. Therefore, redox balance in PVAT emerges as a potential pathophysiological mechanism underlying obesity-induced cardiovascular diseases. In this review, we summarise new findings describing different ROS, the major sources of ROS and antioxidant defence in PVAT, as well as potential pharmacological intervention of PVAT oxidative stress in obesity.
Dynamic Response Threshold Model for Self-Organized Task Allocation in a Swarm of Foraging Robots
Authors: Pang Bao , Zhang Ziqi , Song Yong , Yuan Xianfeng , Xu Qingyang
Published: August 2023

In swarm-robotics foraging, the purpose of task allocation is to adjust the number of active foraging robots dynamically based on the task demands and changing environment. It is a difficult challenge to generate self-organized foraging behavior in which each robot can adapt to environmental changes. To complete the foraging task efficiently, this paper presents a novel self-organized task allocation strategy known as the dynamic response threshold model (DRTM). To adjust the behavior of the active foraging robots, the proposed DRTM newly introduces the traffic flow density, which can be used to evaluate the robot density. Firstly, the traffic flow density and the amount of obstacle avoidance are used to adjust the threshold which determines the tendency of a robot to respond to a stimulus in the environment. Then, each individual robot uses the threshold and external stimulus to calculate the foraging probability that determines whether or not to go foraging. This paper completes the simulation and physical experiments, respectively, and the performance of the proposed method is evaluated using three commonly used performance indexes: the average deviation of food, the energy efficiency, and the number of obstacle avoidance events. The experimental results show that the DRTM is superior to and more efficient than the adaptive response threshold model (ARTM) in all three indexes.
Research on Seismic Performance and Reinforcement Methods for Self-Centering Rocking Steel Bridge Piers
Authors: Zhuge Hanqing , Niu Chenpeng , Du Rui , Tang Zhanzhan
Published: August 2023

To study the seismic performance of self-centering circular-section rocking steel bridge piers whose functions can be restored after an earthquake, a high-precision finite element (FE) analysis model of such a bridge piers was established. The hysteresis behavior of concrete-infilled and hollow rocking steel bridge piers was compared. In response to the characteristics of the local deformation of the wall plates and elliptical deformation of the bottom surface, two reinforcement methods for the pier bottom, namely thickening the wall plate and adding longitudinal stiffeners in the plastic zone of the pier bottom, were proposed. The pseudo static analysis of bridge piers was carried out considering the effects of overall design parameters and reinforcement parameters of the pier bottom. The results indicate that the FE model used in this paper can obtain accurate horizontal load-displacement curves of rocking steel bridge piers. The hysteresis curves of the rocking steel bridge piers and infilled concrete rocking steel bridge piers is close, and directly using hollow steel bridge piers can improve the economic efficiency of the design. Compared to adding longitudinal stiffeners, the reinforcement form of thickened wall plates at the pier bottom has a better effect in improving the seismic performance of bridge piers. The reinforcement of the pier bottom has little effect on the energy dissipation capacity of the bridge pier, but it helps to reduce residual displacement and improve lateral stiffness.
Segmentation Head Networks with Harnessing Self-Attention and Transformer for Insulator Surface Defect Detection
Authors: Guo Jun , Li Tiancheng , Du Baigang
Published: August 2023

Current methodologies for insulator defect detection are hindered by limitations in real-world applicability, spatial constraints, high computational demand, and segmentation challenges. Addressing these shortcomings, this paper presents a robust fast detection algorithm combined segmentation head networks with harnessing self-attention and transformer (HST-Net), which is based on the You Only Look Once (YOLO) v5 to recognize and assess the extent and types of damage on the insulator surface. Firstly, the original backbone network is replaced by the transformer cross-stage partial (Transformer-CSP) networks to enrich the network’s ability by capturing information across different depths of network feature maps. Secondly, an insulator defect segmentation head network is presented to handle the segmentation of defect areas such as insulator losses and flashovers. It facilitates instance-level mask prediction for each insulator object, significantly reducing the influence of intricate backgrounds. Finally, comparative experiment results show that the positioning accuracy and defect segmentation accuracy of the proposed both surpass that of other popular models. It can be concluded that the proposed model not only satisfies the requirements for balance between accuracy and speed in power facility inspection, but also provides fresh perspectives for research in other defect detection domains.