bluuebunny/crossref_metadata_2025 huggingface dataset:
DESTRUCTIVE CHANGES IN THE EDUCATIONAL ACTIVITY OF STUDENTS: MECHANISMS AND TOOLS FOR OVERCOMING
Authors: Крылова М.А.
Published: July 2023

В статье представлена трёхуровневая модель возникновения деструктивных изменений учебной деятельности обучающихся. На каждом уровне задействованы механизмы возникновения деформаций: от выученной беспомощности через компенсацию неуспеха в учёбе иными видами деятельности и до распада смыслов учебной деятельности. На каждом уровне происходит накопление признаков, свидетельствующих о глубине деформации: 1) множественные нарушения учебных действий; 2) выраженность ухода ученика в альтернативную деятельность; 3) распад учебной деятельности. Инструменты преодоления деструктивных изменений в практике успешных педагогов основаны на ключевых внутренних отношениях внутри каждого уровня соответственно: 1) на уровне обратимых изменений через работу в зоне ближайшего развития в плоскости когнитивного развития: операций мышления, процессов памяти и внимания; 2) на имитационно-компенсирующем уровне через работу в зоне ближайшего развития в плоскости формирования и дифференциации рефлексивной самооценки; 3) на уровне распада смыслов деятельности в зоне ближайшего развития в плоскости личностных изменений, психического заражения, авторитета.

The article presents a three-level model of the emergence of destructive changes in the educational activities of students. At each level, the mechanisms of deformations are involved: from learned helplessness through compensation for academic failure by other types of activities and to the disintegration of the meanings of educational activity. At each level, there is an accumulation of signs indicating the depth of deformation: 1) multiple violations of educational activities; 2) the severity of the student's departure to alternative activities; 3) the disintegration of educational activities. The tools for overcoming destructive changes in the practice of successful teachers are based on key internal relationships within each level, respectively: 1) at the level of reversible changes through work in the zone of proximal development in the plane of cognitive development: thinking operations, memory and attention processes; 2) at the imitation-compensating level through work in the zone of proximal development in the plane of formation and differentiation of reflexive self.
Impact of prenatal nutritional interventions on low birth weight in low- and middle-income countries: A systematic review
Authors: Gbèmahon-Roger Houssou  , Colette-Sylvie Azandjeme  , Nadia Fanou  , Schadrac Gbaguidi  , Clémence Metonnou
Published: July 2023

Introduction: Undernutrition during pregnancy is an indicator of intrauterine growth restriction, a critical factor in low birth weight. This review aimed to summarize evidence of nutritional interventions targeting pregnant women to reduce low birth weight in low- and middle-income countries (LMICs). Method: A total of 15 systematic reviews were included for the narrative synthesis after an exhaustive literature search on the search engines Pubmed, google scholar, and the Cochrane database. Systematic reviews of randomized controlled trials evaluating the effect of nutritional interventions during pregnancy on the risk of low birth weight were included. The methodological quality of the included studies was assessed using the AMSTAR assessment tool by two authors. Results: The interventions identified were nutrition education, protein supplementation, lipid supplementation, and multiple or single micronutrients such as vitamin D, iron, zinc, calcium, folic acid, and iodine. Except for vitamin A, iodine, and calcium supplementation, all interventions were useful and could be considered to reduce low birth weight. The effect of zinc supplementation needed to be clarified. Conclusion: Except for vitamin A, iodine, and calcium, all interventions could impact the child's birth weight. Nutritional education interventions should be combined with other strategies, such as supplementation.
Chromium (VI) Removal from Wastewater by Electrocoagulation Process Using Taguchi Method: Batch Experiments
Authors: Al-Nuaimi Amenah S. , Pak Kamal S.
Published: July 2023

Electrocoagulation is an electrochemical method for treatment of different types of wastewater  whereby sacrificial anodes corrode to release active coagulant (usually aluminium or iron cations) into solution, while simultaneous evolution of hydrogen at the cathode allows for pollutant removal by flotation or settling. The Taguchi method was applied as an experimental design and to determine the best conditions for chromium (VI) removal from wastewater. Various parameters in a batch stirred tank by iron metal electrodes: pH, initial chromium concentration, current density, distance between electrodes and KCl concentration were investigated, and the results have been analyzed using signal-to-noise (S/N) ratio. It was found that the removal efficiency of chromium increased with  increasing current density and KCl concentration, and decreases with increasing initial chromium concentration and distance between electrodes, while pH shows peak performance curve. Experimental work have been performed for synthetic solutions and real industrial effluent. The results showed that the removal efficiency of synthetic solution is higher than industrial wastewater, the maximum removal for prepared solution is 91.72 %, while it was 73.54 % for industrial wastewater for the same conditions.
Visual display terminal syndrome and its associated factors among university students during the COVID-19 pandemic
Authors: Kim Hyojin , Kim Se-Jin , Hwang Sujin
Published: July 2023

BACKGROUND: Ever since the start of the coronavirus disease 2019 (COVID-19) pandemic, students have been spending an increasingly longer time staring at electrical devices to take online courses. OBJECTIVE: This study aimed to investigate the effect of the virtual class environment on eye and musculoskeletal problems in university students during the COVID-19 pandemic. METHODS: A total of 365 university students were enrolled in this study. They completed an online survey to examine the effects of online learning on eye and musculoskeletal health during the COVID-19 pandemic. The questionnaires consisted of four sections: demographic and general information, environmental and work factors, device-related factors, and visual display terminal syndrome (VDTS). RESULTS: Participants have been taking online classes of 14.5 hours per week during the COVID-19 pandemic. They reported the mean daily usage of digital devices of 4.8±2.2 hours before the pandemic but this increased to 8.1±2.9 during the pandemic. Eye fatigue and neck, shoulder, and back pain have also been reported. The mean VDTS score was significantly influenced by gender, obesity, daily exercise, regular breaks, wear of blue light-blocking glasses, daily hours of electronic device use, and illumination of room. CONCLUSION: The results of this study showed that university students taking online classes suffered more from VDTS, especially in eye fatigue and neck, lower back, and shoulder pain during COVID-19 pandemic than prior. This study suggests that it is necessary to take breaks in online classes and regularly provide appropriate eye exercise and physical activity to prevent VDTS.
Using tasks in teaching pragmatics
Authors: Pervan Zoran
Published: July 2023

Although pragmatics has been incorporated into pedagogy for many years now, it has often remained on the margins of L2 language teaching where the primary focus was placed on teaching grammar and vocabulary. In the past two decades, however, there has been an increase in interest in teaching L2 pragmatics as it has been claimed that second language acquisition cannot be successful without familiarization with the pragmatics of the second language. This paper aims to give an overview of the research done in second language teaching with a specific accent on TBLT/TSLT as being the framework in which L2 pragmatics teaching can be successful. Tasks are of great importance in teaching pragmatics as they can give a review of a real-work situation in the classroom and in this way bring the learners closer to understanding L2 pragmatics. One special aspect of task-based language teaching is certainly computer-mediated TBLT which can facilitate the creation of tasks and in such a way promote L2 task-based pragmatics teaching.
Early oral feeding following intestinal anastomosis surgery in infants: a multicenter real world study
Authors: Lu Changgui , Sun Xinhe , Geng Qiming , Tang Weibing
Published: July 2023

Background

To prevent postoperative complications, delayed oral feeding (DOF) remains a common model of care following pediatric intestinal anastomosis surgery; however, early oral feeding (EOF) has been shown to be safe and effective in reducing the incidence of complications and fast recovery after pediatric surgery. Unfortunately, the evidence in support of EOF after intestinal anastomosis (IA) in infants is insufficient. Therefore, this study was primarily designed to evaluate the safety and efficacy of EOF. In addition, the current status of EOF application and associated factors that favor or deter EOF implementation were also assessed.

Methods

A total of 898 infants were divided into two groups (EOF group, n = 182; DOF group, n = 716), and the clinical characteristics were collected to identify the factors associated with EOF in infants. Complications and recovery were also compared to define the safety and efficacy after balancing the baseline data by propensity score matching (PSM) (EOF group, n = 179; DOF group, n = 319).

Results

The total EOF rate in infants with IA was 20.3%. Multivariate logistic regression revealed significant differences in the EOF rates based on IA site and weight at the time of surgery (OR = 0.652, 95% CI: 0.542–0.784, p < 0.001) and (OR = 1.188, 95% CI: 1.036–1.362, p = 0.013), respectively. The duration of total parenteral nutrition (TPN), parenteral nutrition (PN), and postoperative hospital stay were significantly shorter in the EOF group than the DOF group [2.0 (1.0, 2.0) d vs. 5.0 (3.0, 6.0) d; 6.0 (5.0, 8.0) d vs. 8.0 (6.0, 11.0) d; 10.0 (7.0, 14.0) d vs. 12.0 (9.0, 15.0) d, all p < 0.001]. The rates of abdominal distension and vomiting in the EOF group were significantly higher than the DOF group (17.9% vs. 7.2%, p < 0.001; 7.8% vs. 2.5%, p = 0.006); however, no differences were found in failure to initial OF, diarrhea, hematochezia, and anastomotic leakage between the two groups (p > 0.05).

Conclusion

The overall rate of EOF in infants following IA was low, and the sites of anastomosis and weight at surgery were two factors associated with EOF. Nevertheless, performing EOF in infants after IA was safe and effective, reduced PN usage, shortened the hospital stay, and did not increase the rate of severe complications.

Clinical Trial Registration: ClinicalTrails.gov, identifier NCT04464057.
GC-MS chemical profiling, antioxidant, anti-diabetic, and anti-inflammatory activities of ethyl acetate fraction of Spilanthes filicaulis (Schumach. and Thonn.) C.D. Adams leaves: experimental and computational studies
Authors: Ojo Oluwafemi Adeleke , Ogunlakin Akingbolabo Daniel , Gyebi Gideon Ampoma , Ayokunle Damilare IyinKristi , Odugbemi Adeshina Isaiah , Babatunde Dare Ezekiel , Ajayi-Odoko Omolola Adenike , Iyobhebhe Matthew , Ezea Samson Chukwuemeka , Akintayo Christopher Oloruntoba , Ayeleso Ademola , Ojo Adebola Busola , Ojo Omolara Olajumoke
Published: July 2023

Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-diabetic, and anti-inflammatory activities of the ethyl acetate fraction of Spilanthes filicaulis leaves (EFSFL) via experimental and computational studies.

Methods: After inducing oxidative damage with FeSO4, we treated the tissues with different concentrations of EFSFL. An in-vitro analysis of EFSFL was carried out to determine its potential for antioxidant, anti-diabetic, and anti-inflammatory activities. We also measured the levels of CAT, SOD, GSH, and MDA.

Results and discussion: EFSFL exhibited anti-inflammatory properties through membrane stabilizing properties (IC50 = 572.79 μg/ml), proteinase inhibition (IC50 = 319.90 μg/ml), and inhibition of protein denaturation (IC50 = 409.88 μg/ml). Furthermore, EFSFL inhibited α-amylase (IC50 = 169.77 μg/ml), α-glucosidase (IC50 = 293.12 μg/ml) and DPP-IV (IC50 = 380.94 μg/ml) activities, respectively. Our results indicated that induction of tissue damage reduced the levels of GSH, SOD, and CAT activities, and increased MDA levels. However, EFSFL treatment restores these levels to near normal. GC-MS profiling shows that EFSFL contains 13 compounds, with piperine being the most abundant. In silico interaction of the phytoconstituents using molecular and ensembled-based docking revealed strong binding tendencies of two hit compounds to DPP IV (alpha-caryophyllene and piperine with a binding affinity of −7.8 and −7.8 Kcal/mol), α-glucosidase (alpha-caryophyllene and piperine with a binding affinity of −9.6 and −8.9 Kcal/mol), and to α-amylase (piperine and Benzocycloheptano[2,3,4-I,j]isoquinoline, 4,5,6,6a-tetrahydro-1,9-dihydroxy-2,10-dimethoxy-5-methyl with a binding affinity of −7.8 and −7.9 Kcal/mol), respectively. These compounds also presented druggable properties with favorable ADMET. Conclusively, the antioxidant, antidiabetic, and anti-inflammatory activities of EFSFL could be due to the presence of secondary metabolites.
Supply Chain Optimization Strategies for Enhanced Efficiency and Performance
Authors: - Sonalika Kumari , - Ramesh Kumar
Published: July 2023

This article looks at supply chain optimization and what it means to make operations more efficient and effective. Supply chain management is a significant part of businesses because it ensures that materials, information, and resources move smoothly from vendors to clients. However, supply lines often need help in product management, market volatility, shipping costs, and teamwork among parties. This article aims to show how different strategies and
methods, such as inventory management, demand projections, transportation optimization, and buyer relationship management, can be used to improve supply chain operations. These tactics allow businesses to become more competitive, cut costs, improve customer happiness, and grow sustainably. This research aims to give a complete picture of supply chain optimization
methods and how they affect business performance and efficiency. By using these tactics, businesses can improve their supply chain processes, cut costs, improve customer happiness, and gain a competitive edge in the market. Practitioners and academics need to keep up with the latest trends and technologies in supply chain optimization to deal with the challenges and
opportunities in a business world that is becoming more complicated and changing quickly.
Centralized control system for islanded minigrid
Authors: Almihat Mohamed G Moh , Kahn MTE
Published: July 2023

This study proposes a centralized control system for an islanded multivariable minigrid to improve its performance, stability and resilience. The integration of renewable energy sources and distributed energy storage systems into microgrid networks is a growing trend, particularly in remote or islanded areas where centralized grid systems are not available. The proposed control system is designed to be implemented at two levels a high-level control system and a low-level control system. Hence, the high-level control system balances energy resources and demand, makes decisions for effective resource utilization and monitors energy transactions within the minigrid. Real-time data from various sources and advanced algorithms are used to optimize energy management and distribution enabling the integration of renewable energy sources and enhancing the resilience of the minigrid against power outages.

Moreover, the low-level control system monitors energy parameters such as voltage, current, frequency and mechanical energy. The control system ensures these parameters remain within the specified range, maintaining system stability and ensuring efficient energy distribution. It also protects the minigrid against power outages improving system reliability and security. Finally, the proposed centralized control system offers a promising solution for improving the performance, stability and resilience of microgrid networks. The system provides real-time monitoring, efficient energy management and distribution, and the integration of renewable energy sources. These results have important implications for the development and deployment of microgrid networks in remote or islanded areas.
Frano Supilo i osvajanje Dubrovačke općine 1899.
Authors: Marinović Stijepo
Published: July 2023

Ovaj rad prikazuje političke okolnosti u Dubrovniku potkraj 19. stoljeća. Najprije se izlažu opće političke prilike u gradu u drugoj polovici 19. stoljeća, odnosno razdoblje dok je u gradskoj općini na vlasti bila Narodna stranka. Prikaz uključuje i Autonomašku stranku te Srpsku stranku, koje zajedno pobjeđuju na izborima 1890. U sljedećem poglavlju objašnjava se srbokatolički fenomen, koji je pridonio popularnosti i utjecaju Srpske stranke. Opisan je i razvoj pokreta srbokatoličkog pokreta, od njegovih korijena sve do osvajanja dubrovačke općine. Nadalje, rad se bavi Franom Supilom te, kroz njegovo djetinjstvo i mladost, prati njegov ideološki razvoj koji se odvija usporedno s usponom mladog pravaštva. U radu se analizira kako se Supilo istaknuo u predvodnika pravaša te se opisuje njihovo političko djelovanje u časopisu Crvena Hrvatska. Naposljetku, rad se zaključuje pregledom borbe za općinsku vlast između Srpske stranke i Autonomaške stranke s jedne, te pravaša i Narodne stranke s druge strane, koja završava povratkom općine u hrvatske ruke.
The Echoes of the Croatian Spring in Slavonia from the Perspective of The Voice of Slavonia
Authors: Stuhli Antonio
Published: July 2023

This paper provides an overview of the main events of the Croatian spring with an emphasis on Osijek and Slavonia, i.e., how the events from Zagreb influenced social conditions in Slavonia from the perspective of The Voice of Slavonia, as the only daily newspaper published in eastern Croatia in that period. The introductory chapter briefly describes the history of the publication of The Voice of Slavonia and its importance in presenting the event. Then, an attempt is made to determine the period of activity of the Croatian Spring and to show the events in Slavonia at that time. In the continuation of the paper, the events that led to the collapse of the movement and the echoes of those events in the organizations of the League of Communists in Osijek and Slavonia are presented.
Innovative Integration of Digital Storytelling and College English Education in China from the Perspective of New Liberal Arts
Authors: Cai Xiuxing
Published: July 2023

In the context of constructing new liberal arts disciplines, college English teaching should break away from traditional language teaching methods and engage in interdisciplinary, cross-specialty, and cross-domain practices. It should leverage disciplinary strengths and actively serve societal needs to promote positive narratives about China. As an innovative educational tool, digital storytelling plays a crucial role in college English teaching. This paper, based on the perspective of new liberal arts, explores the innovative integration of digital storytelling and college English teaching. It proposes an educational innovation model that encompasses communication, service, innovation, research, and ideological and moral education. This model is guided by the communication of positive narratives about China, with societal and local service as its platform. The model aims to cultivate innovative and interdisciplinary talent capable of cross-cultural communication and application, and emphasizes the reciprocal impact of cross-disciplinary research on society. It focuses on inheriting Chinese culture through an active ideological and moral classroom experience, and explores the potential and value of digital storytelling in effectively presenting China's stories in English. The goal is to enrich college English teaching, enhance students' cross-cultural communication and innovation capabilities, and promote the influence of Chinese narratives in international communication.
7 - Piketty and Africa
Authors: Keita Lansana
Published: July 2023

Abstract
18 - Announcements: CODESRIA, the African Guild of Filmmakers and the Pan African Film & Television Festival (FESPACO): ‘Emergence’ on Screen and on Stage
Authors: System Journal
Published: July 2023

Abstract
CODESRIA Bulletin, Nos 3 & 4, 2016
Authors: System Journal
Published: July 2023

Editorial
Continuing the Erosion of Disciplinary Frontiers in the Study of Africa
New Scientific Committee Members
Debate: The Humanities in the CODESRIA Project
Rethinking the Humanities in CODESRIA’s Programmes, F.E.M.K. SenkoroThoughts on the Humanities in CODESRIA, M. Africanus AvehBeyond the Two Cultures Paradigm, Maria Paula MenesesThe Social Sciences and Humanities in the Age of STEM, Ramatoulaye Diagne MbengueOn Collaboration between the Humanities and the Social Sciences, Abdoulaye Niang
ArticlesPiketty and Africa, Lansana KeitaValorizing Social Science Research Results, Ebrima Sall and Mamadou DraméTen Thinkers who want to Complete the Emancipation of Africa, Séverine Kodjo-Grandvaux
ReportsSecurity Regimens in Africa, Ato Kwamena OnomaFaith-based Segregation of Interments in Joal-Fadiouth, Ato Kwamena OnomaCODESRIA Donates Books to African Universities, Abdarahmane WoneThe (Re) making of African Bodies, Ato Kwamena OnomaRethinking Education in the African Context, Sozinho Francisco MatsinheCODESRIA/CASB Summer School, Elísio MacamoNIHSS/CODESRIA African Pathways Programme, Ibrahim Oanda
AnnouncementsCODESRIA to Launch Higher Education Policy Initiative (HEPI), Ibrahim OandaCODESRIA/FESPACO: ‘Emergence’ on Screen and on StageEconomic Justice in Africa: Climate Change, Inequalities and Development
TributeSam Moyo: One Year After, Dede Amanor-Wilks
УКРАЇНСЬКЕ КОЗАЦТВО У ТВОРЧОСТІ CАМУЕЛЯ ЗІ CКРИПНИ ТВАРДОВСЬКОГО
Authors: Pylypenko Volodymyr
Published: July 2023

Метою роботи є проаналізувати образ українського козацтва у творах польського поета середини XVII ст. Самуеля Твардовського. Завдання роботи: визначити, якими термінами користувався Твардовський для опису українського козацтва, що ці терміни означали для освічених читачів XVII ст., як змінювалися описи козацтва в творах Твардовського. Актуалізація теми. Українське козацтво лишається однією з популярних тем в українській історіографії. Але окрім досліджень історії власне козацтва, цікаво поглянути на козацтво з іншого боку – зрозуміти, як бачила козаків польська інтелектуальна еліта, які способи вирішення конфліктів вони пропонували.   Самуель Твардовський був одним із відомих письменників сер. XVII ст. Його вплив на розвиток польської літератури визнавали вже сучасники. До теми українського козацтва він звернувся досить пізно, тоді, коли вже не було сенсу її ігнорувати. На мою думку, «відсутність» козаків у текстах Твардовського протягом 1630–1640 рp. можна пояснити тим, що поет не хотів зайвий раз злити своїх покровителів і потенційних меценатів. Твором, в якому поет проявив власне ставлення до козаків, до повстання та козацьких ватажків, була поема «Wojna domowa». Головними ознаками козаків у поемі стали: велика кількість, безликість (майже не нотує імена ватажків, окрім Богдана та Тимофія Хмельницьких, М. Кривоноса, І. Богуна), жорстокість, зрадливість. Окремо слід відмітити характеристику Б. Хмельницького як тирана.   Висновки. Вокабуляр Самуеля Твардовського мав як досить поширені терміни й поняття для характеристики козаків, так складні поняття класичної політичної теорії. Наприклад, термін тиран, який у поета мав подвійне значення.
Development of a travel recommendation algorithm based on multi-modal and multi-vector data mining
Authors: Liu Ruixiang
Published: July 2023

Given the rise of the tourism industry, there is an increasing urgency among tourists to access information about various tourist attractions. To address this challenge, innovative solutions have emerged, utilizing recommendation algorithms to offer customers personalized product recommendations. Nonetheless, existing recommendation algorithms predominantly rely on textual data, which is insufficient to harness the full potential of online tourism data. The most valuable tourism information is often found in the multi-modal data on social media, characterized by its voluminous and content-rich nature. Against this backdrop, our article posits a groundbreaking travel recommendation algorithm that leverages multi-modal data mining techniques. The proposed algorithm uses a travel recommendation platform, designed using multi-vector word sense segmentation and multi-modal data fusion, to improve the recommendation performance by introducing topic words. In our final experimental comparison, we verify the recommendation performance of the proposed algorithm on the real data set of TripAdvisor. Our proposed algorithm has the best degree of confusion with various topics. With a LOP of 20, the Precision and MAP values reach 0.0026 and 0.0089, respectively. It has the potential to better serve the tourism industry in terms of tourist destination recommendations. It can effectively mine the multi-modal data of the tourism industry to generate more excellent economic and social value.
Identificação de estudos para a elaboração de um roadmap de processo de gestão ágil de portfólio de projetos para universidades
Authors: De Santana Leandro Tenorio , De Azevedo Marília Macorin
Published: July 2023

O processo de transformação digital tem impacto na administração pública, conjunto, como universidades públicas, tanto quanto as atividades ativas quanto a administração. Além de quais são as mais importantes, como instituições internacionais ou eventos do plano estratégico de tecnologia da informação e comunicação. Como também, projetos de projetos de eventos e eventos, os quais são os implantes de melorias, novos produtos, serviços e outros.  O projeto de pesquisa como um processo que pode ser encontrado em diversos elementos para monitores, controles e projetos de acompanhamento, vinculando uma estratégia com uma execução. Neste sentido, o presente estudo tem como objetivo identificar quais são os estudos que contribuem para a construção de um roteiro processo de gestão do porto de tecnologia da informação e comunicação para uma universidade pública. Os objetivos específicos são: analisar uma evolução das publicações; identificador como redes de colaboração; mapear os principais periódicos; avaliar o impacto dos estudos.  Uma metodologia aplicada é uma bibliometria e para o processo de filtragem e seleção de artigos básicos - não há protocolo prisma-p. Os resultados indicam um comentário sobre a mídia de arte publicada nos últimos cinco anos. O Brasil aparece como um dos principais contribuintes para esse tipo de pesquisa e trabalho e valores significativos para os mapeados. Como possível limite de arte, O produto é um produto de peso mais amplo ou mais um tipo de base de processo.Este estudo é parte de um projeto de pesquisa mais ampla e um caso anterior envolvendo uma revisão da literatura e do desenvolver um roteiro de processo.
A Mitochondrion‐Inspired Magnesium–Oxygen Biobattery with High Energy Density In Vivo
Authors: He Er , Ren Junye , Wang Lie , Li Fangyan , Li Luhe , Ye Tingting , Jiao Yiding , Li Dan , Wang Jiacheng , Wang Yuanzhen , Gao Rui , Zhang Ye
Published: July 2023

Implantable batteries are urgently needed as a power source to meet the demands of the next generation of biomedical electronic devices. However, existing implantable batteries suffer from unsatisfactory energy density, hindering the miniaturization of these devices. Here, a mitochondrion‐inspired magnesium–oxygen biobattery that achieves both high energy density and biocompatibility in vivo is reported. The resulting biobattery exhibits a recorded energy density of 2517 Wh L–1/1491 Wh kg–1 based on the total volume/mass of the device in vivo, which is ≈2.5 times higher than the current state‐of‐the‐art, and can adapt to different environments for stable discharges. The volume of the magnesium–oxygen biobattery can be as thin as 0.015 mm3 and can be scaled up to 400 times larger without reducing the energy density. Additionally, it shows a stable biobattery/tissue interface, significantly reducing foreign body reactions. This work presents an effective strategy for the development of high‐performance implantable batteries.
Pharmacokinetic and Bioequivalence Evaluation of Two Cefprozil Dispersible Tablets in Healthy Chinese Volunteers
Authors: Xu Lang , Su Jianfen , Muhetaer Halimulati , Zhang Canhua , Huang Chen , Tang Yukuan , Fu Xihua , Liang Zhimin
Published: July 2023

This study aimed to assess the bioequivalence of 2 cefprozil dispersible tablet formulations (250 mg) in healthy Chinese volunteers under fasting and fed conditions and to determine the pharmacokinetics of cefprozil. A randomized, single‐dose, open‐label, 2‐formulation, 2‐period study was conducted. The elimination period for this study was 7 days. Forty‐eight healthy volunteers received 250‐mg cefprozil dispersible tablets in each study period under both test and reference conditions. The test and the reference cefprozil were bioequivalent in healthy Chinese volunteers, and there was no significant food effect in individuals receiving either formulation. No serious adverse event was recorded, and no volunteers withdrew from the study.
Adaptive tuning of uncertain parameters in a numerical weather prediction model based upon data assimilation
Authors: Zängl Günther
Published: July 2023

In numerical weather prediction models, near‐surface quantities like 10‐m wind speed (FF10M) or 2‐m temperature (T2M) tend to exhibit significantly larger forecast errors than the related variables in the free troposphere. Besides representativeness issues of surface stations, this is primarily related to parametrization errors and insufficient knowledge of relevant physical properties of the soil and the surface layer. For instance, the vegetation roughness length is usually derived from land‐cover classifications that may contain errors and reflect only part of the natural variability. This article describes a methodology implemented into Deutscher Wetterdienst's operational numerical weather prediction model ICON in order to improve the estimate of such parameters by using information from the data assimilation system. Building upon the condition that FF10M, T2M, and 2‐m relative humidity are assimilated, time‐filtered assimilation increments are calculated for the respective fields at the lowest model level. These are taken as proxies for the related model biases. For T2M, an additional weighted increment field is computed that indicates the model bias in the diurnal temperature amplitude. Based on these increment fields, several physical parameter fields and a few model tuning parameters are varied around their base values. This adaptive parameter adjustment is used operationally in the global and regional forecasting systems of Deutscher Wetterdienst. The ensuing reduction of the FF10M, T2M, and 2‐m relative humidity errors typically lies on the order of 5% on a hemispheric average but has substantial regional and seasonal variability that depends on the original magnitude of the model error. A weaker but still statistically significant positive impact is seen in the radiosonde verification of wind speed, humidity, and temperature in the lower troposphere, giving confidence that the adaptive tuning indeed reduces model errors rather than pushing the model towards unrepresentative station observations.
Correlation Between Altmetric Scores and Citation Count in 4 High-Impact Plastic Surgery Journals
Authors: Smartz Taylor M , Jabori Sinan K , Djulbegovic Mak B , Watane Arjun , Sayegh Yoseph , Lyons Nicole , Singh Devinder P
Published: July 2023

Background

The Altmetric Attention Score (AAS) aims to determine the impact of research articles throughout the internet and social media outlets. The AAS is a weighted average of the interaction on platforms including Twitter, Facebook, Reddit, and more.

Objectives

The aim of this study was to investigate the relationship between the AAS and traditional bibliometrics across plastic surgery journals.

Methods

Articles, number of citations (NOC), and H-index information in Annals of Plastic Surgery (APS), Plastic and Reconstructive Surgery (PRS), Plastic and Reconstructive Surgery Global Open (PRS GO), and Aesthetic Surgery Journal (ASJ) from 2017, 2018, and 2019 were queried with the Scopus Online Tool. AAS metrics were collected with the Altmetric Score Calculator Bookmarklet. Descriptive statistics, Spearman rank-correlation analyses, and analyses of variance were performed to measure associations between NOC and AAS.

Results

A total of 3612 articles were analyzed. NOC was weakly correlated with AAS in APS, PRS GO, and ASJ, and moderately correlated with AAS in PRS. NOC was weakly correlated with Twitter mentions in APS, PRS GO, and ASJ, and moderately correlated in PRS. NOC was weakly correlated with news outlet reporting. The H-index of the first author showed more significant correlations with the AAS than the H-index of the last author.

Conclusions

NOC and H-index of the first author correlated with AAS in the plastic surgery literature, suggesting AAS may be a useful adjunct to traditional bibliometrics when evaluating the impact and reach of peer-reviewed articles.
Differential effects of plant and animal fats on obesity‐induced dyslipidemia and atherosclerosis in Ldlr−/−.Leiden mice
Authors: Morrison Martine C. , Egelandsdal Bjørg , Harvei Silje , Rocha Sérgio D. C. , Pieterman Elsbet J. , Kleemann Robert , Carlsen Harald
Published: July 2023

Cardiovascular disease (CVD) is closely associated with obesity through risk factors such as dyslipidemia and chronic low‐grade inflammation, which may be affected by diet. Dietary fats have been extensively studied in relation to CVD risk, however these studies have not always yielded consistent results, most likely due to lack in control of experimental conditions and confounding factors. Here we studied the effects of different plant and animal fats on dyslipidemia, inflammation, and atherosclerosis. Ldlr−/−.Leiden mice were fed isocaloric energy‐dense diets with translational macronutrient composition for 28 weeks. The diets were identical apart from the type of fat they contained: either (1) a mixture of olive and rapeseed oil, (2) sunflower oil, (3) pork fat, (4) beef fat, or (5) milk fat. The fatty acid composition of the diets was determined and effects on circulating lipid and inflammatory risk factors and atherosclerosis were examined, complemented by adipose tissue histology and liver transcriptomics. While visceral fat mass, adipocyte size, and adipose tissue inflammation were not differentially affected by the diets, atherosclerotic lesion load and severity was more pronounced with increasing dietary saturated fatty acid content and decreasing monounsaturated and polyunsaturated fatty acid content, and hence most pronounced with beef and milk fat. These differential effects were accompanied by increases in pro‐atherogenic plasma lipids/lipoproteins (e.g., triglycerides, apolipoprotein B), activation of pro‐atherogenic cytokine/chemokine signaling pathways in liver, and with circulating pro‐atherogenic mediators of inflammation altogether providing a rationale for the differential effects of plant and animal fats.
Effect of massive cerebellar infarction on the outcomes of patients with acute basilar artery occlusion during hospitalization after endovascular treatment: A retrospective study
Authors: Wu Chuyue , Wang Jing , Zhang Lina , Yan Fei , Yang Zhenjie , He Lei , Guo Jing
Published: July 2023

Acute basilar artery occlusion (ABAO) after endovascular treatment (EVT) is often associated with a poor prognosis, particularly in patients with cerebellar infarction who may develop malignant cerebellar edema. The present study aimed to investigate how massive cerebellar infarction (MCI) affects hospitalization outcomes in ABVO patients who undergo EVT. We conducted a retrospective study of ABVO patients who underwent EVT at our hospital between September 2017 and September 2022. MCI was diagnosed using imaging techniques, and various prognostic scores were assessed during hospitalization to examine the relationship between MCI and these outcomes. We identified 42 ABAO patients, of whom 22 (52.4%) had MCI. Patients with MCI had a higher modified Rankin Scale (mRS) score at discharge compared to those without MCI (4.36 ± 1.14 vs 3.05 ± 1.85, P = .042, odds ratio [OR] (95% confidence interval [CI]) = 1.093 (0.083, 2.103)), and a lower Glasgow Coma Scale score (6.59 ± 4.0 vs 10.10 ± 5.07, P = .036, OR (95% CI) = −3.444 (−6.518, −0.369)). MCI was identified as an independent risk factor for an extremely poor prognosis (mRS ≥ 5) at discharge (P = .036, OR (95% CI) = 15.531 (1.603, 313.026)) and for no improvement in mRS score compared to onset (P = .013, OR (95% CI) = 0.025 (0.001, 0.274)). Additionally, an extremely poor prognosis was independently associated with stent implantation, EVT duration, and body mass index, while mRS score improvement was correlated with EVT duration and pulmonary infection. MCI in ABAO patients is a significant independent risk factor for a poor prognosis at discharge and no improvement in function score compared to onset. Early diagnosis and intervention are necessary to improve outcomes, particularly in high-risk populations.
Effect of repeated intravitreal anti-vascular endothelial growth factor drugs on corneal nerves
Authors: Qi Yuanyuan , Cui Lin , Zhang Li , Yan Chunxiao , Jiang Yao , Ye Shuang , Ji Lili , Qiu Yuanyuan , Zhang Lijun
Published: July 2023

To investigate the potential effect of repeated intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs on corneal nerves. A total of 64 patients were treated with intravitreal injection of anti-VEGF drugs. There were 19 cases of neovascular age-related macular degeneration (AMD), 20 cases of diabetic macular edema (DME) and 25 cases of retinal vein occlusion (RVO). Twenty-nine cases were treated with aflibercept (2 mg/0.05 mL) whereas 35 cases were managed with ranibizumab (0.5 mg/0.05 mL). A corneal confocal microscope was used to collect images of corneal subbasal nerve plexus, and Image J was used for image analysis. The changes in corneal nerve were compared between 1 month after each injection and before injection. There were no significant differences in the density and length of corneal nerve at specific time after the surgery in comparison with baseline in patients who were given 3 intravitreal injections. There was no significant correlation between the numbers of injections and the changes of the corneal nerves. After 3rd injection, the nerve length of the DME group was markedly lower than that of AMD and RVO groups, the difference was statistically significant (P < .05). The nerve density of the DME group was not significantly different from that of AMD and RVO groups, whereas the nerve length and nerve density of the AMD and RVO groups were not statistically significant between each other also. The corneal nerve length after the 2nd and 3rd injections of Aflibercept were lower than that before surgery, the difference was statistically significant. There were no significant differences in nerve density and nerve length at each time point after Ranibizumab injection. The length and density of the corneal nerve after multiple injections in contralateral eye displayed no significant changes compared with the baseline. Repeated intravitreal anti-VEGF drug can reduce the length of corneal nerves. For patients who need repeated intravitreal injections of anti-VEGF drugs, especially in DM, attention should be paid on the changes affecting the corneal nerves. It is also needed to strengthen the local anti-inflammatory therapy to avoid infection and to use artificial tears to protect the microenvironment of the ocular surface after the surgery.
CD3D and CD247 are the molecular targets of septic shock
Authors: Yang Qian , Feng Zhijuan , Ding Danyang , Kang Chunbo
Published: July 2023

Septic shock is a serious systemic disease with circulatory failure and abnormal cell metabolism caused by sepsis. However, the relationship between CD3D and CD247 and septic shock remains unclear. The septic shock datasets GSE33118 and GSE142255 profiles were generated from the gene expression omnibus databases GPl570, GPl17586. Differentially expressed genes (DEGs) were screened and weighted gene co-expression network analysis was performed. The construction and analysis of protein–protein interaction (PPI) network, functional enrichment analysis, gene set enrichment analysis (GSEA) were performed. Gene expression heat map was drawn. Immune infiltration analysis was performed. Comparative toxicogenomics database (CTD) analysis were performed to find the disease most related to the core gene. Targets can was used to screen miRNAs regulating the hub DEGs. 467 DEGs were identified. According to the gene ontology analysis, they were mainly enriched in the regulation of immune response, cell activation, signaling receptor activity, enzyme binding. Kyoto encyclopedia of genes and genomes analysis showed that they were mainly enriched in the TCR signaling pathway, Fc epsilon RI signaling pathway. GSEA showed that the DEGs were mainly enriched in immune response regulation, cell activation, TCR signaling pathway, Fc epsilon RI signaling pathway. Positive regulation of Fc receptor signaling pathway, PID IL12 2 pathway, immune response was observed in go enrichment items in the enrichment items of metascape. PPI networks got 5 core genes. Gene expression heat map showed that 5 core genes (CD247, Lck, cd3e, cd3d, ITK) were lowly expressed in the sepsis shock samples and highly expressed in the normal samples. CTD analysis showed that 5 core genes (CD247, Lck, cd3e, cd3d, ITK) were found to be associated with hemorrhage and necrosis. Low expression of cd3d, CD247 was observed in septic shock, and the lower the level of cd3d, CD247, the worse the prognosis.
Acetabular fractures from Judet and Letournel to the present: Research trends and global outcomes with bibliometric analysis during 1980 to 2022
Authors: Dündar Abdulrahim , İpek Deniz , Kaya Şehmuz
Published: July 2023

Fractures of the acetabulum are one of the most challenging injuries treated by orthopedic surgeons. However, a bibliometric analysis has not been performed in the literature on acetabular fractures, which seriously affect the quality of life of patients. The aim of this study was to summarize the bibliometric and intellectual structure, and determine and map the most recent trends on the topic of acetabular fractures by analyzing the social and structural relationships between the different research components of articles published on the acetabular fractures. 1599 articles on acetabular fractures published between 1980 and 2022 were extracted from the Web of Science (WoS) database and analyzed. Bibliometric visualization maps were used to reveal trending topics, citation analyses, and international collaborations. Spearman correlation analysis was performed for correlation investigations. The trend in the expected number of articles to be published over the next few years was displayed using the exponential smoothing estimator. The top 3 contributing countries to the literature were United States of America (USA) (551, 34.4%), China (170, 10.6%), and Germany (160, 10%). The most active author was Berton R. Moed (n = 29) and the most active institution was the University of California System (n = 41). A high-level statistically significant correlation was found between the number of articles on the topic of acetabular fractures published by nations and the gross domestic product (GDP) and GDP per capita values of those countries (R = 0.719, P < .001; R = 0.701, P < .001, respectively). The trending topics researched in recent years were 3D printing, 3-dimensional printing, outcomes, Open Reduction and Internal Fixation (ORIF), mortality, Kocher-Langenbeck, Pararectus approach, tranexamic acid, transfusion, epidemiology, fracture mapping, modified Stoppa approach, post-traumatic osteoarthritis, pelvis fracture, pelvic trauma, fracture reduction, and pelvic ring injury. The leading countries in research on the subject of acetabular fractures were seen to be western countries with large economies (especially the USA, European countries, and Canada) and China, India and Turkey.
Risk factors of infection among close contacts of COVID-19: A systematic review and meta-analysis
Authors: Gao Chun , Jiang Jing-Jing , Mao Jun-Feng , Yu Xiao-Hui , Zheng Xiao-Feng , Zhang Jiu-Cong
Published: July 2023

Background:

Coronavirus disease 2019 (COVID-19) was first detected in December 2019, and declared as a pandemic by the World Health Organization (WHO) on March 11, 2020. The current management of COVID-19 is based generally on supportive therapy and treatment to prevent respiratory failure.

Methods:

PubMed, Web of Science, Embase, CNKI, and other databases were searched by computer, and relevant literature published from December 2019 to November 2022 on the influencing factors of infection in close contacts with novel coronavirus pneumonia was collected. Meta-analysis was carried out after literature screening, quality assessment, and data extraction.

Results:

A total of 425 articles were retrieved and 11 were included. Meta-analysis showed that there were 6 risk factors, and the combined OR value and 95% CI of each influencing factor were 5.23 (3.20, 8.57) for family members, 1.63 (0.56, 4.77) for regular contact, 2.14 (0.62, 7.32) for the elderly, 0.58 (0.001569.89) for cohabitation, 1.97 (1.02, 3.82) for women and 0.75 (0.01, 54.07) for others. The Deeks’ funnel diagram indicates that there is no potential publication bias among the included studies.

Conclusion:

Family members and gender differences are the risk factors of infection among close contacts, and it cannot be proved that there are differences in infection among frequent contact, advanced age, and living together.