bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Chlorodifluoromethyl Phenyl Sulfone: A Novel Non‐ozone‐depleting Substance‐Based Difluorocarbene Reagent for O‐ and N‐Difluoromethylations.
Authors: Zheng Ji , Li Ya , Zhang Laijun , Hu Jinbo , Meuzelaar Gerrit Joost , Federsel Hans‐Juergen
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Practical Transition Metal Free Aryl‐Aryl Coupling Method: Arynes as Key Intermediates.
Authors: Leroux Frederic R. , Bonnafoux Laurence , Heiss Christophe , Colobert Francoise , Lanfranchi Don Antoine
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cationic Pd(II)/Bipyridine‐Catalyzed Addition of Arylboronic Acids to Arylaldehydes. One‐Pot Synthesis of Unsymmetrical Triarylmethanes.
Authors: Lin Shaohui , Lu Xiyan
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of New SILP Catalysts Using Chitosan as Support.
Authors: Baudoux Jerome , Perrigaud Katy , Madec Pierre‐Jean , Gaumont Annie‐Claude , Dez Isabelle
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoinduced C—Br Homolysis of 2‐Bromobenzophenones and Pschorr Ring Closure of 2‐Aroylaryl Radicals to Fluorenones.
Authors: Moorthy Jarugu Narasimha , Samanta Subhas
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Improved Synthesis of Aryl‐Substituted Anthracenes and Heteroacenes.
Authors: Li Guijie , Zhou Shaolin , Su Guowei , Liu Yuanhong , Wang Peng George
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Optical Resolution of Dibenzo[a,g]fluorenol via Glycosylation.
Authors: Banik Bimal K. , Mukhopadhyay Chhanda , Logan Curtis R. , Becker Frederick F.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4‐Alkoxycarbonyl‐butenolides by Uncatalyzed One‐Pot Cyclization of 1,3‐Bis(silyloxy)alk‐1‐enes with Oxalyl Chloride.
Authors: Dede Ruediger , Michaelis Lars , Fuentes Dilver , Yawer Airza Arfan , Hussain Ibrar , Fischer Christine , Langer Peter
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Step Synthesis of 5‐(4‐Fluorobenzyl)‐2‐furyl Methyl Ketone (III): A Key Intermediate of HIV‐Integrase Inhibitor S‐1360 (IV).
Authors: Izumi Kenji , Kabaki Mikio , Uenaka Masaaki , Shimizu Sumio
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrophilic Cyclization of 4‐Thio‐but‐2‐yn‐1‐ols via 1,2‐Migration of the Thio Group: Efficient Synthesis of 2,4‐Dihalo‐3‐thio‐substituted Furans
Authors: Zhou Hongwei , Yao Jinzhong , Liu Guoliang
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of 3‐Substituted‐2‐pyridin‐2‐ylindoles: Regioselectivity of Larock′s Indole Annulation with 2‐Alkynylpyridines.
Authors: Roschangar Frank , et al. et al.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient N‐Aroylation of Substituted Indoles with N‐Aroylbenzotriazoles.
Authors: Katritzky Alan R. , Khelashvili Levan , Mohapatra Prabhu P. , Steel Peter J.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Greener and Rapid Access to Bioactive Heterocycles: Room Temperature Synthesis of Pyrazoles and Diazepines in Aqueous Medium.
Authors: Polshettiwar Vivek , Varma Rajender S.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis and Single Crystal X‐Ray Structures of Some Sterically Congested Electron‐Poor N‐Vinyl Pyrazole Derivatives.
Authors: Noshiranzadeh Nader , Ramazani Ali , Mahyari Amir Tofangchi , Slepokura Katarzyna , Lis Tadeusz
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4(5)‐Acyl‐2‐aminoimidazoles and Vinylogues.
Authors: Poeverlein Christoph , Jacobi Nicolas , Mayer Peter , Lindel Thomas
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Bis‐ and Trisoxazole Derivatives via Suzuki—Miyaura Cross‐Coupling Reaction and van Leusen Oxazole Synthesis.
Authors: Kotha Sambasivarao , Shah Vrajesh R.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis of Highly Substituted Isoxazoles by Electrophilic Cyclization: An Efficient Synthesis of Valdecoxib.
Authors: Waldo Jesse P. , Larock Richard C.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recyclization of Pyrimidinium Salts into 1,2,4‐Triazole Derivatives.
Authors: Danagulyan G. G. , Panosyan G. A. , Sahakyan L. G.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Structure of 2,4,6,8‐Tetramethyl‐3,7‐dithia‐2,4,6,8‐tetraazabicyclo[3.3.0]octane 3,3,7,7‐Tetraoxide.
Authors: Gazieva G. A. , Lysenko K. A. , Kravchenko A. N. , Lebedev O. V.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antimicrobial Activity of 4‐Aryl‐5‐tetra‐O‐benzoyl‐β‐D‐glucopyranosylimino‐3‐thio‐1,2,4‐dithi azolidines.
Authors: Dhonde M. G. , Deshmukh S. P.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Coumarin Derivatives with Nucleophiles in Aqueous Medium.
Authors: Kidwai Mazaahir , Priya Priya , Rastogi Shweta
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Synthesis of Functionalized 2‐Pyridinones from Malonyl Dichloride, Alkylamines and Dimethyl Acetylenedicarboxylate.
Authors: Yavari Issa , Souri Sanaz
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling Reaction as the Key Step for the Synthesis of Some New 4′‐Aryl and Alkyl Substituted Analogues of Amodiaquine and Amopyroquine.
Authors: Paunescu Emilia , Matuszak Nicolas , Melnyk Patricia
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lewis Acid and Organocatalyst Cocatalyzed Multicomponent Reactions of 2‐Alkynylbenzaldehydes, Amines, and Ketones.
Authors: Ding Qiuping , Wu Jie
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rearrangement of Furo[2,3‐c]quinoline‐2,4(3aH,5H)‐diones to Furo[3,4‐c]quinoline‐3,4(1H,5H)‐diones.
Authors: Kafka Stanislav , Kosmrlj Janez , Klasek Antonin , Pevec Andrej
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Efficient Synthesis of Pyrido[2,3‐c]coumarin Derivatives by Palladium‐Catalyzed Heck Cyclization.
Authors: Majumdar Krishna C. , Chattopadhyay Buddhadeb , Taher Abu
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 124. Synthesis and Structure of Ethyl 2‐Bromomethyl‐5‐oxo‐1,2,6,7,8,9‐hexahydro‐5H‐oxazolo [3,2‐a]quinoline‐4‐carboxylate.
Authors: Ukrainets I. V. , Bereznyakova N. L. , Gorokhova O. V. , Turov A. V. , Shishkina S. V.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Reactions of Some Substituted Heterocyclic Systems as Antiarrhythmic Agents.
Authors: Abdulla Mohamed M.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: PtCl4‐Catalyzed Domino Synthesis of Fused Bicyclic Acetals.
Authors: Dieguez‐Vazquez Alejandro , Tzschucke C. Christoph , Lam Wing Yee , Ley Steven V.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Improved Synthesis of α‐Phosphonoenamines Based on a Modified Peterson Olefination.
Authors: McNulty James , Das Priyabrata , Gosciniak Don
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Preparation of α,α‐Dialkyl‐α‐(phenylselanyl)acetates and α,β‐Unsaturated Esters from the Corresponding α,α‐Dialkyl‐α‐cyanoacetates by a Lithium Naphthalenide Induced Reductive Selenenylation Process.
Authors: Ko Yen‐Chun , Zhu Jia‐Jiang
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Versatile Strategy for the Synthesis of N‐Linked Glycoamino Acids from Glycals.
Authors: Kumar Vipin , Ramesh Namakkal G.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Tri‐, Hexa‐, and Nonasaccharide Subunits of the Atypical O‐Antigen Polysaccharide of the Lipopolysaccharide from Danish Helicobacter pylori Strains.
Authors: Fulse Dinanath Baburao , Jeon Heung Bae , Kim Kwan Soo
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Four New Colchicinoids, Gloriosamines A—D, from Gloriosa rothschildiana.
Authors: Kitajima Mariko , Tanaka Akiko , Kogure Noriyuki , Takayama Hiromitsu
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Phenylethanoid Glycoside and Other Constituents from the Fruits of Forsythia koreana.
Authors: El‐Desouky Samy K. , Kim Young‐Kyoon
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2‐Hydroxymethyl‐2‐propylpropane‐1,3‐diol in the Synthesis of Acetal‐Like and Phosphacyclic Lipids.
Authors: Savin G. A.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two New Noriridoids from Scyphiphora hydrophyllacea
Authors: Zeng Yan‐Bo , Mei Wen‐Li , Zhao You‐Xing , Dai Hao‐Fu
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Syntheses of (+)‐7‐epi‐Goniofufurone, (+)‐Goniopypyrone and (+)‐Goniofufurone from a Common Precursor.
Authors: Yadav Veejendra K. , Agrawal Divya
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Family of Ionic Liquids Based on N,N‐Dialkyl‐3‐azabicyclo[3.2.2]nonanium Cations: Organic Plastic Crystal Behavior and Highly Reversible Lithium Metal Electrodeposition.
Authors: Ruether Thomas , Huang Junhua , Hollenkamp Anthony F.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Applications of Tripodal [S3] and [Se3] L2X Donor Ligands to Zinc, Cadmium and Mercury Chemistry: Organometallic and Bioinorganic Perspectives
Authors: Parkin Gerard
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Zinc‐Containing Materials
Authors: Afzaal Mohammad , Malik Mohammad A. , O'Brien Paul
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Strapped and Other Topographically Nonplanar Calixpyrrole Analogues. Improved Anion Receptors
Authors: Lee Chang‐Hee , Miyaji Hidekazu , Yoon Dae‐Wi , Sessler Jonathan L.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biogenesis and Biomimetic Chemistry: Can Complex Natural Products Be Assembled Spontaneously?
Authors: Gravel Edmond , Poupon Erwan
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Dialkylaminopyridine Catalysts in Asymmetric Synthesis
Authors: Wurz Ryan P.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Anhydride Openings
Authors: Atodiresei Iuliana , Schiffers Ingo , Bolm Carsten
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Catalysis Mediated by Synthetic Peptides
Authors: Davie Elizabeth A. Colby , Mennen Steven M. , Xu Yingju , Miller Scott J.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Ring‐Opening Polymerization
Authors: Kamber Nahrain E. , Jeong Wonhee , Waymouth Robert M. , Pratt Russell C. , Lohmeijer Bas G. G. , Hedrick James L.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chalcogenides as Organocatalysts
Authors: McGarrigle Eoghan M. , Myers Eddie L. , Illa Ona , Shaw Michael A. , Riches Samantha L. , Aggarwal Varinder K.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Biology of 1,2‐Naphthoquinone, a Novel Air Pollutant, tat Affects Signal Transduction Pathways
Authors: Sumi Daigo , Kumagai Yoshito
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biocatalytic Reductions: From Lab Curiosity to “First Choice”
Authors: De Wildeman Stefaan M. A. , Sonke Theo , Schoemaker Hans E. , May Oliver
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrogenation Processes in the Synthesis of Perfumery Ingredients
Authors: Saudan Lionel A.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: [(Bisphosphine) Ru(II) Diamine] Complexes in Asymmetric Hydrogenation: Expanding the Scope of the Diamine Ligand
Authors: Hems William P. , Groarke Michelle , Zanotti‐Gerosa Antonio , Grasa Gabriela A.
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pharmaceutical Skill Using Displacement of Protein Binding for Pharmacists
Authors: Takamura Norito , Tokunaga Jin , Chosa Etsuo , Kawai Keiichi , Fujita Ken‐ichi , Arimori Kazuhiko
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Developments in Asymmetric Hydrogenation from an Industrial Perspective
Authors: Shimizu Hideo , Nagasaki Izuru , Matsumura Kazuhiko , Sayo Noboru , Saito Takao
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nuclear Spin Relaxation Parameters of MRI Contrast Agents — Insight from Quantum Mechanical Calculations
Authors: Yazyev Oleg V. , Helm Lothar
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solid‐State NMR Spectroscopy of Amyloid Proteins
Authors: Heise Henrike
Published: March 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Tautomeric Persistence of Electronically and Sterically Biased 2‐Quinolinones
Authors: Volle Jean‐Noël , Mävers Ursula , Schlosser Manfred
Published: March 2008

One dozen of tailormade model 3‐fluoro‐2(1H)‐quinolinones were synthesized in order to be investigated by UV‐, IR‐ and NMR spectroscopic techniques. All of these compounds were found to exist predominantly, if not exclusively, in the lactam (carboxamide, 1,2‐dihydro‐2‐oxoquinoline) form. No tautomeric lactim (iminol, azaphenol) structure was detected. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Least‐squares spectral element method applied to the Euler equations
Authors: Gerritsma Marc , van der Bas Rokus , De Maerschalck Bart , Koren Barry , Deconinck Herman
Published: March 2008

This paper describes the application of the least‐squares spectral element method to compressible flow problems. Special attention is paid to the imposition of the weak boundary conditions along curved walls and the influence of the time step on the position and resolution of shocks. The method is described and results are presented for a supersonic flow over a wedge and subsonic, transonic and supersonic flow problems over a bump. Copyright © 2008 John Wiley & Sons, Ltd.
Zwischen den Welten
Authors: Schaeffer Magdalena
Published: March 2008

Zu Gast im DFG‐Verbindungsbüro in Delhi
Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1‐PBX1 fusion gene in a myoepithelioma
Authors: Brandal Petter , Panagopoulos Ioannis , Bjerkehagen Bodil , Gorunova Ludmila , Skjeldal Sigmund , Micci Francesca , Heim Sverre
Published: March 2008

Chromosome banding as well as molecular cytogenetic methods are of great help in the diagnosis of mesenchymal tumors. Myoepithelial neoplasms of soft tissue including myoepitheliomas, mixed tumors, and parachordomas are diagnoses that have been increasingly recognized the last few years. It is still debated which neoplasms should be included in these morphologically heterogeneous entities, and the boundaries between them are not clear‐cut. The pathogenetic mechanisms behind myoepithelial tumors are unknown. Only five parachordomas and one mixed tumor have previously been karyotyped, and nothing is known about their molecular genetic characteristics. We present a mesenchymal tumor classified as a myoepithelioma that had a balanced translocation t(1;22)(q23;q12) as the sole karyotypic change. A novel EWSR1‐PBX1 fusion gene consisting of exons 1–8 of the 5′‐end of EWSR1 and exons 5–9 of the 3′‐end of PBX1 was shown to result from the translocation. Both genes are known to be targeted also by other neoplasia‐specific translocations, PBX1 in acute lymphoblastic leukemia and EWSR1 in several solid tumors, most of which are malignant. Based on the structure of the novel fusion gene detected, its transforming mechanism is thought to be the same as for other fusion genes involving EWSR1 or PBX1. © 2008 Wiley‐Liss, Inc.
Increase of MCP‐1 (CCL2) in myelin mutant Schwann cells is mediated by MEK‐ERK signaling pathway
Authors: Fischer Stefan , Weishaupt Andreas , Troppmair Jakob , Martini Rudolf
Published: March 2008

Macrophages are critically involved in the pathogenesis of genetically caused demyelination, as it occurs in inherited demyelinating neuropathies. On the basis of the observation that upregulation of the Schwann cell‐derived chemokine MCP‐1 (CCL2) is a pathologically relevant mechanism for macrophage activation in mice heterozygously deficient for the myelin component P0 (P0+/−), we posed the question of the intracellular signaling cascade involved. By using western blot analysis of peripheral nerve lysates the MAP‐kinases extracellular signal‐regulated kinase 1/2 (ERK1/2) and MAP kinase/ERK kinase 1/2 (MEK1/2) showed an early and constantly increasing activation in P0 mutants. Furthermore, in nerve fibers from the P0+/− mutants, Schwann cell nuclei were much more often positive for phosphorylated ERK1/2 than in nerve fibers from wild type mice. In vitro experiments using the MEK1/2‐inhibitor CI‐1040 decreased ERK1/2‐phosphorylation and MCP‐1 expression in a Schwann cell‐derived cell line. Finally, systemic application of CI‐1040 lead to a decreased ERK1/2‐phosphorylation and substantially reduced MCP‐1‐production in peripheral nerves of P0+/− mutant mice. Our study identifies MEK1/2‐ERK1/2 signaling as an important intracellular pathway that connects the Schwann cell mutation with the activation of pathogenetically relevant macrophages in the peripheral nerves. These findings may have important implications for the treatment of inherited peripheral neuropathies in humans. © 2008 Wiley‐Liss, Inc.
Syntheses of isotope‐labeled tobacco‐specific nitrosamines and their metabolites
Authors: Desai Dhimant , Krzeminski Jacek , El‐Bayoumy Karam , Amin Shantu
Published: March 2008

We report here on the syntheses of three deuterium‐labeled tobacco‐specific nitrosamines namely [2,4,5,6‐d4]nitrosonornicotine([2,4,5,6‐d4]NNN), 4‐(methylnitrosamino)‐1‐(3‐[2,4,5,6‐d4]pyridyl)‐1‐butanone ([2,4,5,6‐d4]NNK), and 4‐(methylnitrosamino)‐1‐(3‐[2,4,5,6‐d4]pyridyl)‐1‐butanol ([2,4,5,6‐d4]NNAL). A metabolite of NNK and myosmine, 4‐hydroxy‐1‐(3‐[2,4,5,6‐d4]pyridyl)‐1‐butanone, was also synthesized. The synthetic strategy reported here is similar to that reported in the literature for the preparation of corresponding unlabeled compounds. The commercially available [2,4,5,6‐d4]ethylnicotinate was used as starting material. During the course of these syntheses [2,4,5,6‐d4]myosmine and [2,4,5,6‐d4]nornicotine were obtained as stable intermediates. These isotope‐labeled compounds are useful internal standards for quantification of TSNA and their metabolites in smokers in molecular epidemiological studies. Copyright © 2008 John Wiley & Sons, Ltd.
Physiological noise in MR images: An indicator of the tissue response to ischemia?
Authors: Wang Harris H. , Menezes Nina M. , Zhu Ming Wang , Ay Hakan , Koroshetz Walter J. , Aronen Hannu J. , Karonen Jari O. , Liu Yawu , Nuutinen Juho , Wald Lawrence L. , Sorensen A. Gregory
Published: March 2008

Purpose

To determine whether measuring signal intensity (SI) fluctuations in MRI time series data from acute stroke patients would identify ischemic tissue.

Materials and Methods

Prebolus perfusion‐weighted MRI data from 32 acute ischemic stroke patients (N = 32) was analyzed as a time series. Ischemic and normal tissue regions were outlined and compared.

Results

The magnitude of the measured SI fluctuations was significantly lower in ischemic regions relative to normal tissue. Spatial differences in these fluctuations occurred in a manner that was different than other perfusion‐based metrics.

Conclusion

Prior studies have shown that SI fluctuations in MRI time series data correspond to the presence of physiological “noise,” which includes vasomotion, an autoregulatory phenomenon that affects the tissue response to ischemia. In this study, SI fluctuations were found to decrease in ischemia, consistent with the notion that small vessels will remain open (fluctuations in vessel diameter will decrease) when there is a challenge to flow. Spatial variation in SI fluctuations appeared to be different from spatial variation seen on other perfusion‐based metrics, suggesting that a separate contrast mechanism is responsible, one that might be of diagnostic and prognostic value in acute stroke in which the ability of tissue to withstand ischemia is currently not well visualized. J. Magn. Reson. Imaging 2008;27:866–871. © 2008 Wiley‐Liss, Inc.
Effects of ozone exposure in rat lungs investigated with hyperpolarized 3He MRI
Authors: Crémillieux Yannick , Servais Stéphane , Berthezène Yves , Dupuich David , Boussouar Aurélien , Stupar Vasile , Pequignot Jean‐Marc
Published: March 2008

Purpose

To investigate the effects of subchronic ozone exposure on rat lung ventilation using hyperpolarized (HP) 3He MRI.

Materials and Methods

A total of 24 Sprague‐Dawley rats, distributed in one control group and four groups exposed to 0.5 ppm ozone concentration for two days or six days, either continuously (22 hours/day) or alternatingly (12 hours/day). A three‐step MRI protocol was designed and applied to each animal, including: 1) 3He gas distribution images acquired at inspiratory capacity, 2) measurements of intrapulmonary 3He diffusion coefficients, and 3) dynamic ventilation acquisitions performed during lung filling with 3He.

Results

No differentiation between animals exposed to ozone and control animals was observed from the ventilation images obtained at inspiratory capacity. The 3He diffusion coefficients were not statistically different from one group to another. Ventilation defects, appearing as delayed lung filling regions and heterogeneous lung filling, were observed in the dynamic lung ventilation image series. The percentage of animals with ventilation defects in the control, two‐day, and six‐day exposed groups were equal to 20%, 43% and 75%, respectively. In the subgroup of the animals exposed six days for 12 hours per day, the percentage of animals exhibiting ventilation defects was equal to 85%.

Conclusion

Heterogeneous obstructive patterns in an experimental animal model of subchronic ozone exposure were observed using HP 3He MRI. J. Magn. Reson. Imaging 2008;27:771–776. © 2008 Wiley‐Liss, Inc.
Two‐dimensional 1H MR spectroscopy of the brain in human immunodeficiency virus (HIV)‐infected children
Authors: Banakar Shida , Thomas M. Albert , Deveikis Audra , Watzl June Q.Y. , Hayes Judy , Keller Margaret A.
Published: March 2008

Purpose

To measure cerebral metabolites in brains of human immunodeficiency virus (HIV)‐infected patients using two‐dimensional (2D) proton (1H) magnetic resonance spectroscopy (MRS), which enables more sensitive detection of metabolites at lower concentrations and delineation of the components of the different choline (Ch) groups in the frequency domain when compared to one dimensional (1D) 1H‐MRS.

Materials and Methods

We examined metabolite/creatine (Cr) and metabolite/Ch ratios in the left frontal brain of 10 HIV‐infected (mean age 13.7 ± 4.7 years) and 11 control (mean age 15.3 ± 4.6 years) adolescents and children using 2D localized chemical shift correlated spectroscopy (L‐COSY). The integrated volume under each 2D metabolite peak was calculated with reference to the diagonal creatine methyl peak (Cr_d) or the diagonal choline trimethylamine peak (Ch_d).

Results

In the HIV‐infected patients, myoinositol (mI)/Cr_d (P = 0.009) and mI/Ch_d (P = 0.006) were elevated. The ratios of the following metabolites were also significantly elevated (P < 0.05): mI‐Ch/Cr_d, γ‐aminobutyrate (GABA)/ Cr_d, GABA/Ch_d, threonine‐lactate (Thr‐Lac)/Cr_d, Thr‐Lac/Ch_d, and N‐acetyl aspartate (NAA)/Cr_d.

Conclusion

We have demonstrated for the first time the feasibility of 2D‐MRS in HIV‐infected children and adolescents to assess cerebral metabolites and found elevated mI and elevated GABA, in the left frontal brain of clinically stable HIV‐infected patients. A larger study population is needed to confirm these pilot GABA findings. J. Magn. Reson. Imaging 2008;27:710–717. © 2008 Wiley‐Liss, Inc.
Hyperpolarized 129Xe MRI of the mouse lung at a low xenon concentration using a continuous flow‐type hyperpolarizing system
Authors: Wakayama Tetsuya , Kitamoto Masakazu , Ueyama Tsuyoshi , Imai Hirohiko , Narazaki Michiko , Kimura Atsuomi , Fujiwara Hideaki
Published: March 2008

Purpose

To apply a continuous flow‐type hyperpolarizing (CF‐HP) system to lung imaging and investigate the feasibility of hyperpolarized 129Xe MRI at a low xenon concentration.

Materials and Methods

Under two conditions where a 3% or 70% xenon gas mixture was constantly supplied, gas‐ and dissolved‐phase 129Xe images and diffusion‐weighted 129Xe‐gas images were obtained from the mouse lung. Signal‐to‐noise ratio (SNR) of the 129Xe images and the apparent diffusion coefficient (ADC) of xenon were compared between the two gas mixtures.

Results

The SNR of gas‐ and dissolved‐phase images were 28.9 ± 5.2 and 12.0 ± 2.0, respectively, using the 70% xenon gas mixture, while they were 22.9 ± 4.8 and 6.8 ± 0.6, using the 3% mixture. The ADC of xenon using the 3% xenon gas mixture was approximately 1.5 times higher than that using the 70% one. These results indicated that the high ADC increases the apparent replenishment rate of gas‐phase magnetization, thus resulting in a reduction of the SNR loss induced by diluting xenon with quenching gases.

Conclusion

The CF‐HP system is useful for lung imaging at an extremely low concentration of xenon, which enables one to fully restrain an anesthetic effect of xenon and to reduce consumption of xenon in a measurement. J. Magn. Reson. Imaging 2008;27:777–784. © 2008 Wiley‐Liss, Inc.
Reduction of truncation artifacts in rapid 3D articular cartilage imaging
Authors: Rakow‐Penner Rebecca , Gold Garry , Daniel Bruce , Stevens Kate , Rosenberg Jarrett , Mazin Samuel , Pauly John , Glover Gary H.
Published: March 2008

Purpose

To reduce Gibbs ringing artifact in three‐dimensional (3D) articular knee cartilage imaging with linear prediction (LP).

Materials and Methods

A reconstruction method using LP in 3D was applied to truncated data sets of six healthy knees. The technique first linearizes the data before applying the prediction algorithm. Three radiologists blindly reviewed and ranked images of the full, truncated, and predicted data sets. Statistical analysis of the radiologists' reviews was performed for image quality, clinical acceptability of the images, and equivalence with the gold standard.

Results

LP applied to 3D knee cartilage imaging allows for 40% decreased scan time while providing image quality with statistical equivalence to a full data set.

Conclusion

3D spoiled gradient echo imaging (SPGR) knee cartilage imaging requires significant scan time. This 40% reduction in scan time will allow such scans to be more feasible without sacrificing clinical acceptability. J. Magn. Reson. Imaging 2008;27:860–865. © 2008 Wiley‐Liss, Inc.
Evaluating local hepatocellular carcinoma recurrence post‐transcatheter arterial chemoembolization: Is diffusion‐weighted MRI reliable as an indicator?
Authors: Goshima Satoshi , Kanematsu Masayuki , Kondo Hiroshi , Yokoyama Ryujiro , Tsuge Yusuke , Shiratori Yoshimune , Onozuka Minoru , Moriyama Noriyuki
Published: March 2008

Purpose

To evaluate the detectability of local hepatocellular carcinoma (HCC) recurrence after transcatheter arterial chemoembolization (TACE) by diffusion‐weighted MR imaging in correlation with those of gadolinium‐enhanced MR imaging.

Materials and Methods

Respiratory‐triggered diffusion‐weighted MR images (b factor, 500 s/mm2; number of averaging, six were obtained in 25 patients with 39 HCCs. Two independent radiologists evaluated diffusion‐weighted MR images, gadolinium‐enhanced MR images after TACE, and assigned confidence levels for postoperative HCC recurrence. Apparent diffusion coefficients (ADCs) in HCCs were also measured. Sensitivities and specificities were compared using an extension of the McNemar test. Observer performance was also determined by ROC curve analysis.

Results

Local recurrences in 14 HCCs and complete tumor necrosis in 25 HCCs after TACE were determined. Sensitivity for the detection of local HCC recurrence was higher on gadolinium‐enhanced MR imaging (82%) than on diffusion‐weighted MR imaging (60.7%) for the two readers in combination and separately (P < 0.05). Specificities were comparably high for both sequences. Az values were higher for gadolinium‐enhanced MR images (0.92) than for diffusion‐weighted MR images (0.74) for readers in combination and separately (P < 0.05). Mean ADC values showed an increase after TACE (P < 0.001).

Conclusion

Diffusion‐weighted MR imaging was not found to be a reliable predictor of local HCC recurrence after TACE as compared with gadolinium‐enhanced MR imaging. J. Magn. Reson. Imaging 2008;27:834–839. © 2008 Wiley‐Liss, Inc.
Minimally invasive precision brain access using prospective stereotaxy and a trajectory guide
Authors: Martin Alastair J. , Hall Walter A. , Roark Christopher , Starr Philip A. , Larson Paul S. , Truwit Charles L.
Published: March 2008

Purpose

To evaluate the capabilities of MR‐guided “prospective stereotaxy” methods for accessing brain structures for biopsy or electrode implantation.

Materials and Methods

MR‐guided biopsy and deep brain stimulator (DBS) electrode implantations were performed with a trajectory guide and real‐time MR guidance. Imaging methods were used to plan the selected path through the brain, appropriately orient the trajectory guide, and monitor the device insertion to assure technical success and screen for hemorrhage. Assessments of technical success rate, targeting accuracy, and complications associated with this technique were performed.

Results

A total of 187 biopsy procedures were performed with guidance via prospective stereotaxy methods. All brain biopsies were diagnostic and two patients sustained superficial wound infections that were treated successfully with antibiotics. One patient died postoperatively of a myocardial infarction despite preoperative medical clearance. A total of 42 DBS electrode insertions were performed in patients with Parkinson's disease or dystonia. The difference between planned and actual electrode position averaged 1.2 mm ± 0.7 mm on the first pass and only a single brain penetration was required in 90% of electrode insertions. Complications included a single asymptomatic hemorrhage and two early infections, with the latter addressed by an adjustment to sterile practice.

Conclusion

Prospective stereotaxy, in combination with a trajectory guide, has been proven capable of efficiently and accurately targeting structures throughout the brain. J. Magn. Reson. Imaging 2008;27:737–743. © 2008 Wiley‐Liss, Inc.