bluuebunny/crossref_metadata_2025 huggingface dataset:
New opportunities in management of patients with retinopathy prematurity (literature review and analysis of own data)
Authors: Katargina L. A. , Demchenko E. N.
Published: December 2020

Insufficient effectiveness of laser coagulation of the avascular retinal areas in retinopathy of prematurity (ROP) plus-disease in zone I and aggressive posterior retinopathy of prematurity (APROP) requires new treatment approaches, based on the regulation of retinal angiogenesis and anti-VEGF drugs use. The BEAT-RAP study, which was the first major randomized study of anti-VEGF therapy in ROP, revealed a higher effectiveness of bevacizumab compared to retinal laser coagulation in stage 3 plus-disease of zone I. A prospective randomized trial, RAINBOW, demonstrated the effectiveness of ranibizumab in plus-disease stages 1, 2 and 3 in zone I and stage 3 in zone II and in APROP, so that the drug may be recommended for use in children with ROP. The demonstrated high effect of anti-VEGF therapy in ROP is consistent with our own data. Anti-VEGF therapy opens up new possibilities in the treatment of a particular class of ROP forms. The advantages of anti-VEGF therapy include higher clinical effectiveness of treatment of ROP type I with localization in the posterior pole (I and posterior II zone), absence of "blockage" of the peripheral retina, lower frequency of myopia development and degree, relative fastness of the procedure, the acceptability for patients whose fundus is difficult to visualize, and somatically burdened patients who are contraindicated for prolonged anesthesia used for retinal laser coagulation. When using anti-VEGF drugs in the post-threshold stages of the disease, one should take account of an increased risk of proliferation progression and retinal detachment development. Premature infants with retinopathy regression after anti-VEGF therapy require a longer duration of regular and frequent follow-up (up to 70 weeks of postmenstrual age) due to the risk of relapse and extraretinal proliferation in future.
Diagnostics and comprehensive recovery treatment of an astenic form of accommodative astenopia in an asteno-neurotic state of psychosomatic genesis. A clinical case
Authors: Ovechkin I. G. , Yudin V. E. , Gadzhiev I. S. , Kozhukhov A. A. , Belikova E. I.
Published: December 2020

Rehabilitation treatment of a patient with symptoms of computer visual syndrome and concomitant asthenic form of accommodative asthenopia in an asthenic-neurotic state of psychosomatic genesis is discussed. The treatment was based on an integrated approach that takes into account diagnostic criteria (the volume of absolute accommodation, indicators of objective accommodation, the severity of asthenopia, the state of psychological adaptation) and the basic principles of medical and rehabilitation measures, including, along with traditional methods of correcting asthenic-neurotic states, sequential and staged physiotherapeutic and optical-reflex effects on the accommodative system of the eye.
“Shadowy objects in the test tubes”: Biocitizenship, Disposable Bodies, and Wasted Lives in Hanif Kureishi’s “The Body” and Kazuo Ishiguro’s Never Let Me Go
Authors:   Assistant Professor of English, School of Social Sciences and Languages, Vellore Institute of Technology, Chennai, Chennai 600127., Karmakar Manali , Parui Avishek ,   Assistant Professor of English, Department of Humanities and Social Sciences, IIT Madras, Chennai, 600036.
Published: December 2020

The paper aims to explore Hanif Kureishi’s (2002) “The Body” and Kazuo Ishiguro’s (2005) Never Let Me Go in order to throw light on the bioethical issues related to ageing, biocitizenship, organ transplantation, wasted lives and disposable bodies by extending the discussion from a human to a dystopian posthuman world where affluent sections of society replenish their aged degenerating organic body by incorporating biomatter from non-citizens and clones. The paper draws on and extends Nikolas Rose and Carlos Novas’s concept of biocitizenship, Zygmunt Bauman’s notion of wasted lives, Giorgio Agamben’s explanation of bare life and Julia Kristeva’s theory of abjection in the context of literary studies in order to analyze the socio-political status of the engineered lives who are classified as biomedical fodders.
Metaphor and Melancholy Consciousness: Enduring Efficacy and Universal Common in Obiora Udechukwu’s Eight Paintings
Authors:   Senior Lecturer, Dept. of Fine & Applied Arts, University of Nigeria, Nsukka, Nigeria, Okpara Chukwuemeka , Aniago Emeka ,   Senior Lecturer, Dept. of Theatre & Film Studies, University of Nigeria, Nsukka, Nigeria, Okpara Tochukwu Felicia
Published: December 2020

This paper analytically discusses the efficacy of Obiora Udechukwu’s eight paintings particularly their commonality in projecting humanity universal common, pervading melancholy consciousness, and their propensity to activate effectual catharsis. This paper also discusses how these eight paintings provide cognitive channels through which plausible interpretive attempt at psychoanalysis of Udechukwu in relation to the paintings can be attained. We are adopting interpretive approach in our attempt at coming up with plausible deductions and extrapolations of the embedded significations in the paintings. To deepen our purview on efficacy of these paintings as stimuli for emotion activation, we shall apply select theories explaining contexts of melancholy consciousness, effectual catharsis and cognitive channels of psychoanalysis in relation to paintings as texts. In the end, our interpretations indicate that Udechukwu’s techniques in these paintings create perpetual atmosphere subsuming consciousness of universally acknowledged debilitating agonies resulting from wars.
Trauma, Body Movement and Mental Health: An Appreciation of Samuel Beckett’s Waiting for Godot
Authors:   Assistant Professor of English, M. U. C. Women’s College, West Bengal, India, Dangar Joyanta
Published: December 2020

This article is intended to create an interdisciplinary space to enable productive dialogue about bodily representation of psychological trauma and its meanings in artistic, literary, visual, and health discourses, with reference to Samuel Beckett’s Waiting for Godot. Drawing on Pat Ogden and her colleagues’ somatic approach to trauma therapy and on Bessel A. van der Kolk’s hypothesis that traumatic experiences of the past manifest in physiological states and actions of the present, the article views postures and body movements of the characters in the play as symptoms of psychological trauma. It shows how the play offers unique insights into the trauma pathology of postwar Europe, which may be valuable to psychiatrists, psychotherapists, rehabilitation workers, victim advocates, and students and interns entering the fields of mental health and trauma treatment.
Numerical study of energy dissipation and block barriers in stepped spillways
Authors: Moghadam Mehdi Karami , Amini Ata , Moghadam Ehsan Karami
Published: December 2020

In this research, the accuracy of the Flow-3D numerical model in the flow simulation in a stepped spillway was probed using data obtained from the physical model. In addition, the effects of block barriers on the energy dissipation rate were investigated. To adopt a proper turbulent model, Renormalization Group k-ε, RNG k-ε, and standard k-ε models were employed. Then, the Flow-3D was run in five discharges for nine spillways with the ratios of block length to step length (Lb/l) and block height to step height (Hb/h) as 0.3, 0.4, and 0.5. The results indicated that both turbulent models had almost similar outcomes though the run time of the RNG k-ε model was shorter. The blocks with a shorter length in low ratios of Hb/h and the lengthier blocks in high ratios of Hb/h undergo more relative energy dissipation relative to the no-block situation. For Hb/h = 0.3 and Lb/l equal to 0.3, 0.4, and 0.5, the relative energy dissipation climbed on average as 8.5, 6.5, and 4.5% respectively, compared with the no-block case. The most influence exerted on relative energy dissipation was obtained via the blocks with Hb/h = Lb/l equal to 0.3 and 0.5 with respective increases of 8.6 and 8.4%.
Optimal operation of multi-reservoir systems: comparative study of three robust metaheuristic algorithms
Authors: Akbarifard Saeid , Sharifi Mohammad Reza , Qaderi Kourosh , Madadi Mohamad Reza
Published: December 2020

In this study, the capability of the recently introduced moth swarm algorithm (MSA) was compared with two robust metaheuristic algorithms: the harmony search (HS) algorithm and the imperialist competitive algorithm (ICA). First, the performance of these algorithms was assessed by seven benchmark functions having 2–30 dimensions. Next, they were compared for optimization of the complex problem of four-reservoir and 10-reservoir systems operation. Furthermore, the results of these algorithms were compared with nine other metaheuristic algorithms. Sensitivity analysis was performed to determine the appropriate values of the algorithms’ parameters. The statistical indices coefficient of determination (R2), root mean square error (RMSE), mean absolute error (MAE), mean square error (MSE), normalized MSE (NMSE), mean absolute percentage error (MAPE), and Willmott’s index of agreement (d) were used to compare the algorithms’ performance. The results showed that MSA was the superior algorithm for solving all benchmark functions in terms of obtaining the optimal value and saving CPU usage. ICA and HS were ranked next. When the dimensions of the problem were increased, the performance of ICA and HS dropped but MSA has still performed extremely well. In addition, the minimum CPU usage and the best solutions for the optimal operation of the four-reservoir system were obtained by MSA, with values of 269.7 seconds and 308.83, which are very close to the global optimum solution. Corresponding values for ICA were 486.73 seconds and 306.47 and for HS were 638.61 seconds and 264.61, which ranked them next. Similar results were observed for the 10-reservoir system; the CPU time and optimal value obtained by MSA were 722.5 seconds and 1,195.58 while for ICA they were 1,421.62 seconds and 1,136.22 and for HS they were 1,963.41 seconds and 1,060.76. The R2 and RMSE values achieved by MSA were 0.951 and 0.528 for the four-reservoir system and 0.985 and 0.521 for the 10-reservoir system, which demonstrated the outstanding performance of this algorithm in the optimal operation of multi-reservoir systems. In a general comparison, it was concluded that among the 12 algorithms investigated, MSA was the best, and it is recommended as a robust and promising tool in the optimal operation of multi-reservoir systems.
Prevention of Information Security Incidents in Automated Information System
Authors:   JSC “concern SYSTEMPROM”, Butusov Igor , Romanov Aleksandr ,   JSC “concern SYSTEMPROM”
Published: December 2020

The purpose of the article is to support the processes of preventing information security incidents in conditions of high uncertainty. Method: methods of mathematical (theoretical) computer science and fuzzy set theory. Result: an information security Incident, including a computer incident, is considered as a violation or termination of the functioning of an automated information system and (or) a violation of information stored and processed in this system, including those caused by a computer attack. Information descriptions are presented in the form of structured data about signs of computer attacks. Structured data is the final sequence of strings of symbols in a formal language. The Damerau-Levenstein editorial rule is proposed as a metric for measuring the distance between strings of characters from a particular alphabet. The possibility of presenting the semantics of information descriptions of attack features in the form of fuzzy sets is proved. Thresholds (degrees) of separation of fuzzy information descriptions are defined. The influence of semantic certainty of information descriptions of features (degrees of blurring of fuzzy information descriptions) on the decision-making about their identity (similarity) is evaluated. It is shown that the semantic component of information descriptions of signs of computer attacks presupposes the presence of some semantic metric (for its measurement and interpretation), which, as a rule, is formally poorly defined, ambiguously interpreted and characterized by uncertainty of the type of fuzziness, the presence of semantic information and the inability to directly apply a probabilistic measure to determine the degree of similarity of input and stored information descriptions of signs. An approach is proposed to identify fuzzy information descriptions of computer attacks and to apply methods for separating elements of reference sets on which these information descriptions are defined. It is shown that the results of the procedure for identifying fuzzy information descriptions of computer attacks depend on the degree of separation of the reference sets and on the indicators of semantic uncertainty of these descriptions
RUSSIAN VESTIBULAR INVESTIGATIONS WITH PRIMATES IN FLIGHTS OF THE BIOSATELLITES
Authors:   Institute of Biomedical Problems of the Russian Academy of Science, Moscow, Kozlovskaya I.B. , Lapin B.A. ,   Research Institute of Medical Primatology, Sochi, Russia, Miller N.V. ,   Institute of Biomedical Problems of the Russian Academy of Science, Moscow, Badakva A.M. ,   Institute of Biomedical Problems of the Russian Academy of Science, Moscow
Published: December 2020

The BION program with primates included 2 vestibular studies one was focused on coordination of the eye and head movements and activities of the medial vestibular nuclei and cerebellum flocculus during angular head movements in the horizontal plane for gaze fixation and the other, on the central vestibular neurons and otolith-induced cardiac rhythm reaction during linear displacement about the body axis. Sensitivity of the central vestibular neurons to both angular and linear accelerations was found to increase at the beginning of microgravity and then normalized gradually, whereas the flocculus activity remained high throughout the mission.
A Three-gene-based Type 1 Diabetes Diagnostic Signature
Authors: Wang Rongrong , Zhou Yanan , Zhang Yan , Li Shaoqing , Pan Runzhou , Zhao Yongcai
Published: December 2020

Background::

Type 1 diabetes is a chronic autoimmune disease featured by insulin deprivation
caused by pancreatic β-cell loss, followed by hyperglycaemia.

Objective:

Currently, there is no cure for this disease in clinical treatment, and patients have to accept a lifelong
injection of insulin. The exploration of potential diagnosis biomarkers through analysis of mass data by bioinformatics
tools and machine learning is important for type 1 diabetes.

Methods:

We collected two mRNA expression datasets of type 1 diabetes peripheral blood samples from GEO,
screened differentially expressed genes (DEGs) by R software, and conducted GO and KEGG pathway enrichment
using the DEGs. Moreover, the STRING database and Cytoscape were used to build PPI network and predict
hub genes. We constructed a logistic regression model by using the hub genes to assess sample type.

Results:

Bioinformatic analysis of the GEO dataset revealed 92 and 75 DEGs in GSE50098 and GSE9006 datasets,
separately, and 10 overlapping DEGs. PPI network of these 10 DEGs showed 7 hub genes, namely
EGR1, LTF, CXCL1, TNFAIP6, PGLYRP1, CHI3L1 and CAMP. We built a logistic regression model based
on these hub genes and optimized the model to 3 genes (LTF, CAMP and PGLYRP1) based logistic model.
The values of the area under the curve (AUC) of training set GSE50098 and testing set GSE9006 were 0.8452
and 0.8083, indicating the efficacy of this model.

Conclusion:

Integrated bioinformatic analysis of gene expression in type 1 diabetes and the effective logistic regression
model built in our study may provide promising diagnostic methods for type 1 diabetes.
Envisioning the Future of Nanomedicines in Management and Treatment of Neurological Disorders
Authors: Kumar Shobhit , Singh Priyanka , Sharma Shrestha , Pottoo Faheem H. , Ali Javed , Baboota Sanjula
Published: December 2020

Neurodegenerative disorders are a result of continuous deterioration of the structure and
function of neurons, involving the death of neurons. Neurodegenerative disorders affect millions of
people around the world. Several conventional drug delivery strategies are available to treat
neurological disorders. However, they are unable to provide adequate cytoarchitecture restoration
and connection patterns due to lower solubility, poor bioavailability, drug resistance and
incapability to traverse the blood-brain barrier (BBB). Therefore, designing and developing new
and efficient delivery systems, that can bring drugs to CNS and have good bioavailability in the
brain is very important. Nano drug delivery system acts as a ray of hope in the diagnosis and
treatment of neurological disorders. The use of nanomedicines encapsulating therapeutic molecules
may enhance transport of drug across BBB, absorption of drug and its controlled release in the
human body with minimum adverse effects. This review article includes a comprehensive
overview of the BBB, recent developments and application of nanomedicines, including liposomes,
nanoparticles, nanomicelles, carbon nanotubes, etc., to the management as well as clinical therapy
of various neurodegenerative disorders.
Teratogenic Toxicity Evaluation of Bladder Cancer-Specific Oncolytic Adenovirus on Mice
Authors: Lu Keqing , Wang Fang , Ma Baoliang , Cao Wenjuan , Guo Qi , Wang Hanzhang , Rodriguez Ronald , Wang Zhiping
Published: December 2020

Background:

In our previous studies, we had demonstrated the efficiency and specificity
of constructed bladder tissue-specific adenovirus Ad-PSCAE-UPII-E1A-AR (APU-EIA-AR) on
bladder cancer. The virus biodistribution and body toxicity in nude mice have also been investigated.
However, the safety of the bladder cancer-specific oncolytic adenovirus on fetal mice and F1
mice should be under intense investigation.

Objectives:

In order to evaluate the teratogenic toxicity of bladder cancer-specific oncolytic adenovirus
APU-EIA-AR on mice, in this study, we investigated the fetal mice weight, fetal body
length and tail length, fetal skeleton development, as well as the F1 mice weight, growth curve, and
major organ pathology. These teratogenic toxicity data of bladder tissue-specific adenovirus Ad-PSCAE-
UPII-E1A-AR (AD) would provide safe information prior to embarking on clinical trials.

Methods:

On the sixth day of being fertilized, the pregnant mice began to be intramuscularly administrated
with AD (1×107VP, 1×108VP, 1×109VP) every other day for ten days. The pregnant
mice were then divided into two groups. One group was euthanized on the seventeenth day; the fetal
mice were taken out, and the bone structure of the infants was observed. The other group was
observed until natural childbirth. The Filial Generation (F1) is fed for 30 days; the variations in the
growth progress and development were assessed. The mice were then euthanized; The tissues from
major organs were harvested and observed under the microscope.

Results:

In the process of teratogenic toxicity test, the Placenta weight, fetal mice weight, body
length, and a tail length of mice fetal in adenovirus treated group did not reveal any alteration.
Meanwhile, comparing with the PBS group, there is no obvious change in the skeleton of fetal
mice treated with adenovirus. During the development process of F1 mice treated with adenovirus,
the changes in mice weight show statistical significance. However, in the progress of the growth
curve, this difference is not very obvious. Furthermore, the pathological section showed no obvious
alteration in major organs.

Conclusion:

Our study demonstrated that bladder cancer-specific adenovirus Ad-PSCAE-UPII-
E1A-AR appears safe in pregnant mice without any discernable effects on fetal mice and F1 development.
Hence, it is relatively safe for tumor gene therapy.
Withdrawal Notice: Fabrication of Bidirectional Electrothermal Microactuator by Two-Photon Polymerization
Authors: Ertugrul Ishak , Waqar Tayyab
Published: December 2020

The article has been withdrawn at the request of the authors of the journal Current Nanoscience.

Bentham Science apologizes to the readers of the journal for any inconvenience this may cause.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Organoids: Current Implications and Pharmaceutical Applications in Liver Diseases
Authors: Zhu Mengqi , Huang Yuting , Bian Saiyan , Song Qianqian , Zhang Jie , Zheng Wenjie , Cheng Chun
Published: December 2020

Understanding organogenesis, disorders, and repairing processes is particularly important
for understanding the disease occurrence and developing treatment approaches. At present, liver-
related studies are mainly conducted using in vivo models and cell lines, making it difficult to
generalize the full picture of the structural characteristics and functions of human organs. Organoid
is a three-dimensional (3D) culture system in vitro, which holds the promise to establish various
disease models and conduct in-depth research by generating organ-like tissues in a dish. Recent advances
in human liver organoids have provided a deeper understanding of this complex organ. In
this review, we provide a systematic overview of the construction methods of organoids, focusing
on their applications in the hepatic organogenesis and various liver disease models, as well as the
limitations of current models. The development of organoid models is proving to be crucial in future
liver research.
Development and evaluation of STEPS, an out-of-class learning planning and monitoring strategy support system for students
Authors: Matsuda Takeshi
Published: December 2020

Self-directed learning (SDL) is a means of providing students with an opportunity to teach themselves skills that will serve them well throughout life. The development of such skills should be seen as existing alongside those taught by teachers; it is often the case that SDL teaches
students how to learn, as well as what to learn. When students are encouraged to partake in SDL it not only enables them to think for themselves, it also reduces the burden on specific teachers and faculty members who might be responsible for hundreds of students. A team of researchers based
at four universities in Japan have come together to develop a Self-Tailored Educational Portal System (STEPS). The team is composed of Professors Takeshi Matsuda and Hiroshi Kato, and Associate Professors Nobuhiko Kondo, Yuki Watanabe and Katsusuke Shigeta. The central idea behind STEPS is
to provide advice to students and enable them to make decisions based on available data.
Shining a light on the cloud
Authors: Annette Lucy
Published: December 2020

The Social Sciences & Humanities Open Cloud (SSHOC) is a 40-month-long project under the umbrella of the European Open Science Cloud (EOSC) and funded by Horizon 2020. This project unites 20 partner organisations as well as their 27 associates. SSHOC seeks to create interconnected
data infrastructures focused on an integrated, cloud-based network structure.
Research on Nonlinear Partial Differential Equations in Mathematical Finance
Authors: Ishimura Naoyuki
Published: December 2020

Mathematical finance is a field of applied mathematics which focuses on crafting special mathematical models and computational methods which are used by the finance markets. The basis of mathematical finance lies in probability theory which focuses on analysing the behaviour of the
markets to help the prediction of any random events. From this work financial companies and individuals interested in the markets can make informed choices based on a calculated risk level. Professor Naoyuki Ishimura has performed research in mathematical finance for many years, and is currently
based at Chuo University, where he is now focusing on assisting in the development of better methods for calculating risk factors. One of his current collaborators is Andres Mauricio Molina Barreto, a doctoral student from Colombia. Together, they have worked on a paper that looks at the Value
at Risk (VaR) for the portfolio problem in the presence of copulas, which help to explain how random variables are dependent on each other.
Development of indicators and tools to measure the design capability of companies
Authors: Yaegashi Kazaru
Published: December 2020

Traditionally, the concept of 'design' is associated with the arts, the way a product looks, the way something is presented or similar. This has been the case for decades. However, something that has emerged in recent years is how design can offer much value to companies, organisations
and the research field of business management. Professor Kazaru Yaegashi is the Chief Producer at the Design Management Lab (DML), which is based at Ritsumeikan University in Japan. The focus of the DML research is on gaining a systematic understanding of the knowledge related to design management,
especially as it relates to design-driven innovation and design thinking in the field of business administration. Yaegashi is focused on developing indicators and tools to evaluate the attitudes and intentions of all members in companies toward design. Taking these and the results of their
previous research, his team is hoping to measure the design capability of companies which will then identify areas for improvement and what needs to change to realise the potential.
Ideas, Movement, and Institutionalisation: A Study on Dissemination Processes of Salafism in South East Asia - Cases of Indonesia, Malaysia, and the Philippines
Authors: Kohno Takeshi , Makruf Jamhari , Wadi Julkipli , Abdullah Kamarulnizam
Published: December 2020

Professor Takeshi Kohno, from Toyo Eiwa University in Japan, has a particular interest in how an idea of Salafism can travel to South East Asia and become an important part of lives of people far from its origin. Kohno is leading a project that seeks to analyse how Salafism turns into
social movement and how this social movement is institutionalised in education institutions. In particular, he along with the team of researchers in Indonesia, Malaysia, and the Philippines are analysing the dissemination processes of Salafism into school system in these countries. By identifying
transformational agents such as the state and its bureaucrats as well as religious teachers, Kohno and his colleagues hope to gain insight into this religious school of thought and how it has become established in Indonesia, Malaysia and the Philippines.
Probióticos na redução de sintomas de ansiedade e depressão: uma revisão integrativa
Authors: Costa Bruna Cunha , Azevedo George Silva dos Santos , Ferreira Pedro Henrique Arruda , Rodrigues Almeida Leila Magda
Published: December 2020

Objetivos: sumarizar estudos que avaliaram a suplementação de probióticos como estratégia terapêutica nos sintomas da ansiedade e depressão. Métodos: revisão integrativa de artigos indexados na base de dados PubMed, SciELO e Biblioteca Virtual em Saúde publicados de janeiro de 2010 a setembro de 2019. Para isso, utilizou-se a conjugação dos descritores: “intestino”, “cérebro”, “microbiota intestinal”, “ansiedade”, “depressão”, “probióticos”, nos idiomas português e inglês. Resultados: Após a aplicação dos critérios de inclusão e exclusão, 13 ensaios clínicos randomizados foram selecionados. O tempo de duração dos estudos, em sua maioria, foi de 8 ou 12 semanas (61,5%; n = 8), e a forma mais ofertada do suplemento foi o probiótico em pó (46,2%; n = 6) e em cápsula (30,8%; n = 4). Sobre a utilização de escalas como parâmetro de avaliação dos sintomas de ansiedade e depressão, 38,5% (n = 5) utilizaram apenas uma escala e 69,2% (n = 8) utilizaram a combinação de duas ou três escalas. Em relação ao gênero das bactérias, a maior parte dos estudos utilizou Lactobacillus e Bifidobacterium em conjunto (53,8%; n = 7). Apesar das limitações metodológicas e dos resultados inconsistentes, a maioria dos ensaios clínicos (76,9%; n = 10) evidenciaram uma redução significativa dos sintomas relacionados à ansiedade e depressão através da suplementação de probióticos. Conclusão: As evidências indicam que a suplementação com probióticos apresenta potencial promissor na redução dos sintomas de ansiedade e depressão, no entanto são necessárias pesquisas adicionais sobre essa estratégia como terapia adjuvante no tratamento efetivo para a saúde mental.
The effectiveness of a smartphone-based online peer group on type II diabetes mellitus patients self-empowerment in a primary healthcare center in Indonesia
Authors: Rosyida Ratna Wirawati , Pertiwi Ariani Arista Putri , Pangastuti Heny Suseani
Published: December 2020

Objective: Self-empowerment is an important factor that influences a person's ability to perform effective diabetes management. One effort that can be done to improve self-empowerment is by providing a smartphone-based online peer-group. This research determined the effect of smartphone-based online peer groups on type 2 diabetes mellitus (T2DM) patients self-empowerment in four primary healthcare centers in Indonesia. Methods: This quasi-experimental research was conducted in four healthcare centers in Indonesia. The total sample was 71 divided into two groups (control and intervention). The control group received standard education from the healthcare center, whereas the intervention group underwent an online peer-group. Self-empowerment was measured before and after intervention using the Diabetes Empowerment Scale-Short Form (DES-SF) questionnaire (Indonesian version). General Linear Model was used in statistical analysis. Results: The mean age of respondents was 56.4 ± 8.8 and 56.9 ± 7.1 years old, 59.5%, and 76.5% had good family support, and 70.3% and 50% of respondents had not received diabetes education for the control and intervention groups, respectively. The average pretest self-empowerment score was 27.03 ± 3.73 and 27.59 ± 3.53 (diff. 0.56; 95%CI -1.16; 2.29), and the post-test score was 27.43 ± 4.13 and 32.76 ± 4.38 (diff. 5.33; 95%CI 3.32; 7.35) for the control and intervention groups, respectively. Online peer-group improve self-empowerment significantly in the intervention group. Conclusion: Smartphone-based online peer-group can improve self-empowerment in patients with T2DM.
The importante of profilaxis in venous thromboembolism
Authors: Burihan Marcelo Calil
Published: December 2020

During the coronavirus pandemic, there has been much discussion worldwide about the prophylaxis of venous thromboembolism (VTE) in hospitalized patients or not. After the pandemic is over or minimized, we must keep this in mind as one of the most critical tasks to be done, during and after hospitalization, regardless of the case.
COVID-19 and stroke: perspectives and concerns
Authors: Freire Marco Aurélio M , Khan Usaamah , Falcão Daniel
Published: December 2020

In December 2019, the first reports of the Coronavirus Disease 2019 (COVID-19) emerged in Wuhan, Hubei Province, China, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with a subsequent outbreak rapidly spreading globally. Since then, the COVID-19 pandemic has impacted society worldwide, and the SAR-CoV-2 virus continues to spread, by infecting more than 55 million people and causing over one million and three-hundred thousand deaths to date. On January 30th, 2020, the World Health Organization (WHO) declared COVID-19 a Public Health Emergency of International concern, having a vast impact on people's behavior, personal relationships, jobs, and the global economy, besides causing a severe burden to the healthcare system.
Creation of a network model on the basis of a universal sequence of construction works
Authors: Karakozova Irina V. , Pavlov Alexander S.
Published: December 2020

Introduction. Building information modeling is the main direction of development of automated design and control systems. An important component of information modeling is the transfer of data into construction management systems. The most complicated issue is the problem of creating the correct graph topology relevant to the process sequence and construction management experience. The development of automated progress schedule compilation system based on the use of a universal sequence developed earlier is examined.

Materials and methods. As a result of the analysis of the progress schedule compilation process, the topology creation algorithm is divided into several stages. At the first stage, a text description of the information model is given, which is then converted into a list of building or structure elements. The list of elements should be transformed into the work item list and then supplemented with work items not reflected in the list of elements. This is a separate complex task, which is not examined in this study, and is the direction of further research by the authors. At the next stage, the work items in the list are assigned codes that define the location of the scope of works in time and space.

Results. An algorithm for converting the work item list into a coherent work schedule, the topology of which takes into account the spatial location of the work area and the sequence of interrelated processes over time, has been developed. The sequence of works is determined by a preliminarily designed universal list. The list of requirements for the information produced by BIM models is developed. Splitting the algorithm into stages allows for manual correction of the work item list and the properties of work items, if necessary.

Conclusions. The developed method allows for automation of the processes of creating construction plans based on the list of building elements and universal work sequence. At any implementation stage, the work item list may be interactively changed and supplemented. In the future, it is necessary to form a set of parameters for structural elements that will allow automating the choice of technological processes.
Identificación y caracterización de las manifestaciones culturales religiosas católicas en Los Antiguos, Provincia de Santa Cruz
Authors: Díaz Viegas Jacquelina , Norambuena Mónica , Ampuero Cristian
Published: December 2020

Una importante cantidad de trabajos podrían mencionarse en torno al estudio de la religión a escalas global y local, pero casi nulos los relacionados a la provincia de Santa Cruz y particularmente a Los Antiguos. Esta localidad, se localiza a 993 km al NO de Río Gallegos, con uno de los valores más bajos en cantidad de habitantes. El presente trabajo forma parte del plan de trabajo de la estudiante de la Licenciatura en Geografía Jacquelina Díaz Viegas como integrante del Proyecto de Investigación 29 A/427-1 “La geografía de las religiones en el ejido municipal de Río Gallegos en el año 2018. La Geografía cultural en la Patagonia austral extraandina”. En este caso, se presenta un estado de avance del mismo. Su objetivo es identificar la influencia territorial de la religión Católica Apostólica Romana en Los Antiguos en el marco de la Geografía cultural y de la Geografía de las religiones. Estas manifestaciones culturales religiosas católicas, se identificaron y caracterizaron a partir de lecturas comprensivas, de la observación directa, en salidas de campo y concertando entrevistas con actores clave en la localidad. Se espera contribuir con la generación de conocimiento a grupos interdisciplinarios abocados al estudio de las Ciencias Sociales, la Geografía y de las religiones, como así también a la formación profesional de la estudiante avanzada.
The relationship between sleep and metabolic factors in diabetes mellitus
Authors: ALTIN Zeynep , BAYRAK Burcu
Published: December 2020

Introduction: This study was conducted to determine the relationship between sleep status and sociodemographic features, body mass index (BMI), blood pressure (BP), additional diseases, duration of diabetes mellitus diagnosis, received therapies, and laboratory values in patients with diabetes mellitus.Methods: The study was carried out with 200 adult diabetic patients applying to the Internal Medicine Department of Tepecik Training and Research Hospital with normal cognitive function and without any known psychiatric disorder. The research was conducted between July 10 and August 31, 2019. Sociodemographic data of patients were recorded, and the Pittsburgh Sleep Quality Index (PSQI) was applied. Those with a total score of 5 or above were considered poor, while those less than 5 were deemed good.Results: Of the 200 patients, 64% (n = 128) were female, and 36% (n = 72) were male. The mean total PDQI score was 10.44. Sleep quality was good in 7.5%, while poor in 92.5%. In both genders, the mean total score was greater than five. However, there was a statistically significant difference according to gender. Namely, 3.9% of women had good sleep quality, which was 13.9% among men (p=0.010). Higher educational status was related to higher sleep quality (p=0.007). Sleep quality was further impaired in patients with additional hypertension, hyperlipidemia, or coronary artery disease (p=0.010). The sleep quality of those living with their spouses was lower than that of other participants (p=0.033). There was no statistically significant difference between mean PUKI total scores and diabetes type, BMI, BP, lipid values, fasting & postprandial blood glucose, creatinine, or ALT values (p>0.05).Conclusion: Sleep quality is poor in diabetics. Clinicians should handle patients' sleep status during diabetes mellitus follow-up. Interventions to increase sleep quality in diabetics will no doubt improve the quality of life.
Reformasi Hukum dan Realisasi Investasi Asing pada Era Presiden Joko Widodo
Authors: Sutrisno Nandang , Poerana Sigar Aji
Published: December 2020

This article discusses two reasearch questions, firstly, whether law reforms on investment by the issuance of policy packages involving massive numbers of regulations during the First Period of President Jokowi have been successful to increase the realization of foreign investments? Secondly, how is the projection of foreign investment policies in the Second Period Of President Joko Widodo to increase the realization of foreign investments? Theoretical framework used in this article methodologically places law as external environment for foreign investors, and that law is the priority factor and the most relevant for investment and economic growth. This article concludes that first, law reforms on investments by the issuance of massive regulations in the First Period, even though having been successful to increase the values of realization of cumulative foreign investments significantly, they have been unsuccessful in increasing the annual percentages of foreign investment growth. Second, Omnibus Law and the then implementing regulations that would be used to increase foreign investments have been inviting resistances from various components of the nation, due to lack of transparent procedures and degrading the interests of public at large, and bias of the intersets of investors. Therefore, the effectiveness of law reforms in the Second Period would be impeded by various resistant movements, and in turn, be contraproductive with the purposes of legal reforms.

Abstrak

Artikel ini membahas dua permasalahan utama, pertama apakah reformasi hukum investasi melalui serangkaian paket kebijakan dengan jumlah peraturan yang masif pada Periode Pertama Presiden Jokowi telah berhasil meningkatkan realisasi investasi asing? Kedua, bagaimanakah proyeksi kebijakan investasi asing pada Periode Kedua Presiden Jokowi untuk meningkatkan realisasi investasi asing? Kerangka teoretik yang digunakan dalam artikel ini secara metodologis menempatkan hukum sebagai lingkungan eksternal dari investasi asing, bahwa hukum merupakan faktor prioritas dan paling relevan untuk investasi dan pertumbuhan ekonomi. Kesimpulan dari artikel ini pertama, reformasi hukum investasi dengan mengeluarkan produk hukum yang masif pada Periode Pertama meskipun berhasil meningkatkan nilai investasi asing kumulatif secara signifikan, tetapi tidak berhasil meningkatkan persentase pertumbuhan pertahunnya. Kedua, Omnibus Law dan peraturan-peraturan pelaksanaanya yang akan diandalkan untuk meningkatkan investasi asing telah mengundang resistensi dari berbagai komponen bangsa, karena secara prosedur pembentukannya tidak transparan dan secara substantif mendegradasi kepentingan masyarakat luas serta lebih berpihak kepada kepentingan para investor. Dengan demikian efektivitas reformasi hukum pada Periode Kedua akan terganggu dengan berbagai gerakan resistensi yang akan menyebabkan kontraproduktif dengan tujuan dari reformasi hukum tersebut.
Aktualisasi Pancasila sebagai Sumber Hukum dalam Pembentukan Undang-Undang
Authors: Arfa'i Arfa'i , Nasution Bahder Johan , Febrian Febrian
Published: December 2020

In the Indonesian legal system, Pancasila is the source of all sources of law, the basis of the national law, and functions as rechtsidee. With such a position, all positive laws should reflect and be in line with Pancasila values. This article aims at exploring how Pancasila values actualized in the legislation of law. This article demonstrates that despite the vital role of Pancasila as long the legislation of law  is concerned, there are no clear indicators and variables indicating that a law has reflected and been in line with Pancasila values. It is also found that there is no model or mechanism for testing whether the law which under legislation has been appropriate and conformed with Pancasila. The current indicators and variables are the ones set by the Agency for National Law Development (BPHN) and the Agency for Pancasila Ideology Education (BPIP), and are used to evaluate a positive law. In fact, they are not the ones intended to to evaluate a law which is currently in the level of legislation. This article argues that in order to actualize Pancasila values in the established law, indicators and variables regarding Pancasila values need to be regulated in a law. Besides, it is encouraged that the evaluation and testing mechanisms be implemented during legislation process.

Abstrak

Dalam sistem hukum Indonesia, Pancasila merupakan sumber dari segala sumber hukum, dasar hukum nasional, dan cita hukum. Dengan kedudukan yang demikian itu, maka sudah seharusnya semua hukum yang dibentuk mencerminkan atau selaras dengan nilai-nilai Pancasila. Artikel ini bermaksud menelusuri bagaimana nilai-nilai Pancasila diaktualisasi dalam pembentukan suatu undang-undang. Dalam artikel ini ditunjukkan, sekalipun Pancasila memiliki peran yang sangat penting bagi suatu undang-undang yang dibentuk, ternyata belum ada indikator dan variabel tentang undang-undang yang mencerminkan atau selaras dengan nilai-nilai Pancasila. Artikel ini juga menunjukkan, belum ada model atau mekanisme pengujian apakah undang-undang yang sedang dalam tahap pembentukannya telah sesuai dan selaras dengan Pancasila. Indikator dan variabel yang ada sejauh ini ialah yang ditetapkan oleh Badan Pembinaan Hukum Nasional dan Badan Pembinaan Ideologi Pancasila, dan digunakan untuk mengevaluasi suatu undang-undang yang telah berlaku, bukan yang sedang dalam tahap pembentukannya. Karena itu, agar nilai-nilai Pancasila semakin teraktualisasi dalam undang-undang yang dibentuk, maka indikator dan variabel tentang nilai-nilai Pancasila perlu diatur dalam undang-undang, dan mekanisme evaluasi dan pengujiannya perlu didorong agar dapat dilakukan pula pada saat undang-undang sedang dalam tahap pembentukannya.
“Estate” fiction on the pages of magazines of the early XX century (“New Way”, “Questions of Life”, “Apollo”, “Capital and Country Estate”)
Authors: Pegova Nadezhda I.
Published: December 2020

The article reviews “estate” fiction on the pages of two magazines — “Novyy put’” (“New Way”) and its successor, “Voprosy Zhizni” (“Questions of life”), magazines that sensitively responded to questions of contemporary reality and published, in partic ular, texts in which had been artistically raised the problems of social and economic dis advantage in the country. The estate theme had also become one of the most important in two other magazines of the second decade of the XX century, “Apollon” (“Apollo”) and “Stolitsa i usad’ba” (“Capital and country estate”), which existed until the fall of 1917.
The poetosphere of the Russian urban estate of the early XX century (according to the literary memoirs of S.N. Durylin “In his native corner”)
Authors:   Academician S.P. Korolev Samara National Research University, Karpenko Gennady Yu.
Published: December 2020

The article discusses the peculiarities of the poetosphere of the Russian urban es tate of the beginning of the XX century (according to the literary memoirs of S.N. Durylin “In the native corner. How old Moscow lived and breathed”), the thesis is consistently proved: the estate world in the image of the writer is theoanthropic and hierarchically centered. These properties find expression 1) in the construction of the estate house, where the icon is the spiritual center, 2) in the good humility and obedience of a person, in his monastic quiet service to the world. The spiritual-anthropological estate reality recreated by S.N. Durylin in the word forms the Eucharistic text of Russian literature.
Mythopoetics of the Siberian estate in the Russian prose of the end of the XIX — the first third of the XX centuries
Authors:   Tyumen State University, Ertner Elena N.
Published: December 2020

For the first time in the history and criticism of literature the article regards the features of the Siberian “estate topos” as a new modification of the Russian culture “estate text”, typical for the literature of the late XIX — the first third of the XX centuries. In the prose of N.A. Lukhmanova, M.M. Prishvin, N.M. Yadrintsev Tyumen merchant estate transforms into a new “cultural space”. The shift from the philosophy of the rural life to the “business” philosophy and the idea of the commercial Siberian estate bring forward the new topos-related notions: “estate is a factory” and “tannery Lyon”. We introduce the comparative mythopoetics of the Siberian city and country estates through the processes of demythologization of classical country “estate myth” and local remythologization of the concepts: “estate is a fortress”, “estate is a garden / a greenhouse”, and “estate is a nest”. The merchant “estate topos” forms at the intersection of the Russian land Paradise lost and the Siberian Eden, newly created by settlers. The Tyumen schismatic estate be comes “the promised land” or the city of Kitezh: the sacred space of secret chapels, “the underground Kingdom of our Fathers’ faith”. The emphasis is also given to the “theatri cality” of the merchant “estate” play behavior.
Artistic meaning of the Russian estate
Authors:   A.M. Gorky Institute of World literature of the Russian Academy of Sciences, Bogdanova Olga A.
Published: December 2020

The Preface reveals the conceptual basis of the collective monograph “The phenomenon of the Russian literary estate: from Chekhov to Sorokin+” — the third issue of the scientific book series “Russian estate in the world context”, it also provides an overview of the topics and problems of the articles contained in it. Promising areas for further work in the series are outlined.