bluuebunny/crossref_metadata_2025 huggingface dataset:
Single-Source Multi-Battery Solar Charger: Analysis and Stability Issues
Authors: Kuperman Alon , Sitbon Moshe , Gadelovits Shlomo , Averbukh Moshe , Suntio Teuvo
Published: June 2015

In this paper, dynamic analysis of a multi-battery dual mode charger, powered by a single solar array and suitable for lead-acid and lithium-ion cell-based batteries is presented. Each battery is interfaced to the solar array by means of a current-controlled buck power stage, operating either in constant power or constant voltage mode. Operation in former/latter charging mode implies regulating input/output voltage of the converter, which is a non-trivial situation since while feeding different batteries, all the converters share the same input terminals, connected to the solar array. It is revealed that when at least one of the batteries operates in constant power charging mode, open-loop instability occurs whenever converter input voltage is lower than maximum power point voltage of the solar array. Consequently, input voltage regulating controller must be designed to stabilize closed-loop dynamics for the worst case of instability, which is also derived. Moreover, it is shown that the dynamics of the converters operating under output voltage control are perceived as disturbances by input voltage control loop and must be properly rejected. Simple loop shaping design is proposed based on a PI controller, allowing stabilizing the system in case of worst case instability and rejecting output voltage control induced disturbances at the expense of non-constant, operating-point dependent closed-loop damping.
Αlpha 2a-Adrenoceptor Gene Expression and Early Life Stress-Mediated Propensity to Alcohol Drinking in Outbred Rats
Authors: Comasco Erika , Todkar Aniruddha , Granholm Linnea , Nilsson Kent , Nylander Ingrid
Published: June 2015

Stressful events early in life, later high alcohol consumption and vulnerability to alcohol use disorder (AUD) are tightly linked. Norepinephrine is highly involved in the stress response and the α2A-adrenoceptor, which is an important regulator of norepinephrine signalling, is a putative target in pharmacotherapy of AUD. The aim of the present study was to investigate the effects of early-life stress and adult voluntary alcohol drinking on the α2A-adrenoceptor. The relative expression and promoter DNA methylation of the Adra2a gene were measured in the hypothalamus, a key brain region in stress regulation. A well-characterized animal model of early-life stress was used in combination with an episodic voluntary drinking in adulthood. Alcohol drinking rats with a history of early-life stress had lower Adra2a expression than drinking rats not exposed to stress. Alcohol intake and Adra2a gene expression were negatively correlated in high-drinking animals, which were predominantly rats subjected to early-life stress. The results provide support for a link between early-life stress, susceptibility for high alcohol consumption, and low Adra2a expression in the hypothalamus. These findings can increase our understanding of the neurobiological basis for vulnerability to initiate risk alcohol consumption and individual differences in the response to α2A-adrenoceptor agonists.
Forecasting and Analyzing the Disease Burden of Aged Population in China, Based on the 2010 Global Burden of Disease Study
Authors: Bao Chengzhen , Mayila Mamat , Ye Zhenhua , Wang Jianbing , Jin Mingjuan , He Wenjiong , Chen Kun
Published: June 2015

Background: Forecasting the disease burden of the elderly will contribute to make a comprehensive assessment about physical and mental status of the elderly in China and provide a basis for reducing the negative consequences of aging society to a minimum. Methods: This study collected data from a public database online provided by Global Burden of Disease Study 2010. Grey model GM (1, 1) was used to forecast all-cause and disease-specific rates of disability adjusted life years (DALYs) in 2015 and 2020. Results: After cross-sectional and longitudinal analysis, we found that non-communicable diseases (NCDs) were still the greatest threats in the elderly, followed by injuries. As for 136 predicted causes, more than half of NCDs increased obviously with age, less than a quarter of communicable, material, neonatal, and nutritional disorders or injuries had uptrend. Conclusions: The findings display the health condition of the Chinese elderly in the future, which will provide critical information for scientific and sociological researches on preventing and reducing the risks of aging society.
Physical Activity and Snus: Is There a Link?
Authors: Henninger Stéphane , Fischer Roland , Cornuz Jacques , Studer Joseph , Gmel Gerhard
Published: June 2015

The study aimed at assessing the link between physical activity (PA), sports activity and snus use among young men in Switzerland. Data from the Cohort Study on Substance Use Risk Factors (C-SURF) were used to measure PA with the International Physical Activity Questionnaire and sports activity with a single item. Multivariate logistic regression analysis was conducted to measure the association between snus use, PA and sports activity. Similar models were run for smoking and snuff use. Snus use increased in a dose-response association with PA (high level: OR = 1.72; 95% CI 1.16–2.55) and with individuals exercising once a week or more often (OR = 1.65; 95% CI 1.26–2.16; p < 0.001) or almost every day (OR = 2.27; 95% CI 1.72–3.01; p < 0.001) in separate models. Entered simultaneously, only sports and exercise maintained a basically unchanged significant dose-response relationship, whereas PA became non-significant. A non-significant dose-response relation was found for cigarette smoking and snuff use, indicating that the association with sport is specific to snus and not to tobacco use in general or smokeless tobacco in particular. This study showed that the association between snus use and sports is not specific to Nordic countries.
Proteomic Identification of Target Proteins of Thiodigalactoside in White Adipose Tissue from Diet-Induced Obese Rats
Authors: Parray Hilal , Yun Jong
Published: June 2015

Previously, galectin-1 (GAL1) was found to be up-regulated in obesity-prone subjects, suggesting that use of a GAL1 inhibitor could be a novel therapeutic approach for treatment of obesity. We evaluated thiodigalactoside (TDG) as a potent inhibitor of GAL1 and identified target proteins of TDG by performing comparative proteome analysis of white adipose tissue (WAT) from control and TDG-treated rats fed a high fat diet (HFD) using two dimensional gel electrophoresis (2-DE) combined with MALDI-TOF-MS. Thirty-two spots from a total of 356 matched spots showed differential expression between control and TDG-treated rats, as identified by peptide mass fingerprinting. These proteins were categorized into groups such as carbohydrate metabolism, tricarboxylic acid (TCA) cycle, signal transduction, cytoskeletal, and mitochondrial proteins based on functional analysis using Protein Annotation Through Evolutionary Relationship (PANTHER) and Database for Annotation, Visualization, Integrated Discovery (DAVID) classification. One of the most striking findings of this study was significant changes in Carbonic anhydrase 3 (CA3), Voltage-dependent anion channel 1 (VDAC1), phosphatidylethanolamine-binding protein 1 (PEBP1), annexin A2 (ANXA2) and lactate dehydrogenase A chain (LDHA) protein levels between WAT from control and TDG-treated groups. In addition, we confirmed increased expression of thermogenic proteins as well as reduced expression of lipogenic proteins in response to TDG treatment. These results suggest that TDG may effectively prevent obesity, and TDG-responsive proteins can be used as novel target proteins for obesity treatment.
Cloning and Characterization of Surface-Localized α-Enolase of Streptococcus iniae, an Effective Protective Antigen in Mice
Authors: Wang Jun , Wang Kaiyu , Chen Defang , Geng Yi , Huang Xiaoli , He Yang , Ji Lili , Liu Tao , Wang Erlong , Yang Qian , Lai Weimin
Published: June 2015

Streptococcus iniae is a major fish pathogen that can also cause human bacteremia, cellulitis and meningitis. Screening for and identification of protective antigens plays an important role in developing therapies against S. iniae infections. In this study, we indicated that the α-enolase of S. iniae was not only distributed in the cytoplasm and associated to cell walls, but was also secreted to the bacterial cell surface. The functional identity of the purified recombinant α-enolase protein was verified by its ability to catalyze the conversion of 2-phosphoglycerate (2-PGE) to phosphoenolpyruvate (PEP), and both the recombinant and native proteins interacted with human plasminogen. The rabbit anti-rENO serum blockade assay shows that α-enolase participates in S. iniae adhesion to and invasion of BHK-21 cells. In addition, the recombinant α-enolase can confer effective protection against S. iniae infection in mice, which suggests that α-enolase has potential as a vaccine candidate in mammals. We conclude that S. iniae α-enolase is a moonlighting protein that also associates with the bacterial outer surface and functions as a protective antigen in mice.
Vascular Calcification and Stone Disease: A New Look towards the Mechanism
Authors: Yiu Allen , Callaghan Daniel , Sultana Razia , Bandyopadhyay Bidhan
Published: June 2015

Calcium phosphate (CaP) crystals are formed in pathological calcification as well as during stone formation. Although there are several theories as to how these crystals can develop through the combined interactions of biochemical and biophysical factors, the exact mechanism of such mineralization is largely unknown. Based on the published scientific literature, we found that common factors can link the initial stages of stone formation and calcification in anatomically distal tissues and organs. For example, changes to the spatiotemporal conditions of the fluid flow in tubular structures may provide initial condition(s) for CaP crystal generation needed for stone formation. Additionally, recent evidence has provided a meaningful association between the active participation of proteins and transcription factors found in the bone forming (ossification) mechanism that are also involved in the early stages of kidney stone formation and arterial calcification. Our review will focus on three topics of discussion (physiological influences—calcium and phosphate concentration—and similarities to ossification, or bone formation) that may elucidate some commonality in the mechanisms of stone formation and calcification, and pave the way towards opening new avenues for further research.
Marine Habitat Mapping Incorporating Both Derivatives of LiDAR Data and Hydrodynamic Conditions
Authors: Smith Grant , Yesilnacar Ertan , Jiang Junsheng , Taylor Christian
Published: June 2015

Accurate and efficient species-based marine habitat assessment is in great demand for the marine environment. Remote sensing techniques including airborne light detection and ranging (LiDAR) derived bathymetry can now be used, in concert with suitable ground truthing, to produce marine habitat maps over wide areas. Hydrodynamic conditions, e.g., current speeds and wave exposure influence habitat types through direct impact on marine organisms, as well as influence on sediment transport and, hence, substrate type. Habitat classification and mapping was carried out using both LiDAR derivatives and hydrodynamic parameters derived from numerical modelling at a location off the coast of Port Hedland in the Pilbara region of Western Australia, 1660 km north of Perth. Habitat classes included seagrass, algae, invertebrates, hard coral, and areas where there is no evident epibenthos. The inclusion of the hydrodynamic parameters significantly increased the accuracy of the classification by 7.7% when compared to using LiDAR derivatives alone.
Nanosized Hydroxyapatite Coating on PEEK Implants Enhances Early Bone Formation: A Histological and Three-Dimensional Investigation in Rabbit Bone
Authors: Johansson Pär , Jimbo Ryo , Kozai Yusuke , Sakurai Takashi , Kjellin Per , Currie Fredrik , Wennerberg Ann
Published: June 2015

Polyether ether ketone (PEEK) has been frequently used in spinal surgery with good clinical results. The material has a low elastic modulus and is radiolucent. However, in oral implantology PEEK has displayed inferior ability to osseointegrate compared to titanium materials. One idea to reinforce PEEK would be to coat it with hydroxyapatite (HA), a ceramic material of good biocompatibility. In the present study we analyzed HA-coated PEEK tibial implants via histology and radiography when following up at 3 and 12 weeks. Of the 48 implants, 24 were HA-coated PEEK screws (test) and another 24 implants served as uncoated PEEK controls. HA-coated PEEK implants were always osseointegrated. The total bone area (BA) was higher for test compared to control implants at 3 (p < 0.05) and 12 weeks (p < 0.05). Mean bone implant contact (BIC) percentage was significantly higher (p = 0.024) for the test compared to control implants at 3 weeks and higher without statistical significance at 12 weeks. The effect of HA-coating was concluded to be significant with respect to early bone formation, and HA-coated PEEK implants may represent a good material to serve as bone anchored clinical devices.
New Analysis Method Application in Metallographic Images through the Construction of Mosaics Via Speeded Up Robust Features and Scale Invariant Feature Transform
Authors: Filho Pedro , Moreira Francisco , Xavier Francisco , Gomes Samuel , Santos José , Freitas Francisco , Freitas Rodrigo
Published: June 2015

In many applications in metallography and analysis, many regions need to be considered and not only the current region. In cases where there are analyses with multiple images, the specialist should also evaluate neighboring areas. For example, in metallurgy, welding technology is derived from conventional testing and metallographic analysis. In welding, these tests allow us to know the features of the metal, especially in the Heat-Affected Zone (HAZ); the region most likely for natural metallurgical problems to occur in welding. The expanse of the Heat-Affected Zone exceeds the size of the area observed through a microscope and typically requires multiple images to be mounted on a larger picture surface to allow for the study of the entire heat affected zone. This image stitching process is performed manually and is subject to all the inherent flaws of the human being due to results of fatigue and distraction. The analyzing of grain growth is also necessary in the examination of multiple regions, although not necessarily neighboring regions, but this analysis would be a useful tool to aid a specialist. In areas such as microscopic metallography, which study metallurgical products with the aid of a microscope, the assembly of mosaics is done manually, which consumes a lot of time and is also subject to failures due to human limitations. The mosaic technique is used in the construct of environment or scenes with corresponding characteristics between themselves. Through several small images, and with corresponding characteristics between themselves, a new model is generated in a larger size. This article proposes the use of Digital Image Processing for the automatization of the construction of these mosaics in metallographic images. The use of this proposed method is meant to significantly reduce the time required to build the mosaic and reduce the possibility of failures in assembling the final image; therefore increasing efficiency in obtaining results and expediting the decision making process. Two different methods are proposed: One using the transformed Scale Invariant Feature Transform (SIFT), and the second using features extractor Speeded Up Robust Features (SURF). Although slower, the SIFT method is more stable and has a better performance than the SURF method and can be applied to real applications. The best results were obtained using SIFT with Peak Signal-to-Noise Ratio = 61.38, Mean squared error = 0.048 and mean-structural-similarity = 0.999, and processing time of 4.91 seconds for mosaic building. The methodology proposed shows be more promissory in aiding specialists during analysis of metallographic images.
Redox-Active Profile Characterization of Remirea maritima Extracts and Its Cytotoxic Effect in Mouse Fibroblasts (L929) and Melanoma (B16F10) Cells
Authors: Dória Grace , Santos Anderson , Bittencourt Leonardo , Bortolin Rafael , Menezes Paula , Vasconcelos Bruno , Souza Rebeca , Fonseca Maria , Santos Alan , Saravanan Shanmugam , Silva Francilene , Gelain Daniel , Moreira José , Prata Ana , Quintans-Júnior Lucindo , Araújo Adriano
Published: June 2015

Remirea maritima is a tropical plant with a reticulated root system belonging to the family Cyperaceae, also known to have biologically active secondary metabolites. However, very few data on R. maritima’s biological actions are available and there are no reports regarding the redox-active profile of this plant. In this study, we examined the total phenolic content of Remirea maritima hydroalcoholic (RMHA) extracts, redox properties against different reactive species generated in vitro and their cytotoxic effect against fibroblasts (L929) and melanoma (B16F10) cells. Total reactive antioxidant potential index (TRAP) and total antioxidant reactivity (TAR) results revealed that RMHA at all concentrations tested showed significant antioxidant capacity. RMHA was also effective against hydroxyl radical formation, reduction of Fe3+ to Fe2+ and in scavenging nitric oxide (NO) radicals. In vitro, the level of lipid peroxidation was reduced by RMHA extract and the data showed significant oxidative damage protection. The RMHA cytotoxicity was evaluated by a neutral red assay in fibroblast (L929) and melanome (B16F10) cells. The obtained results showed that the RMHA (40 and 80 µg/mL, respectively) reduced 70% of the viable cells. In conclusion, this study represents the first report regarding the antioxidant and anti-proliferative potential of R. maritima against B16F10 melanoma cells.
A Traditional Diet Is Associated with a Reduced Risk of Eczema and Wheeze in Colombian Children
Authors: Cepeda Alfonso , Del Giacco Stefano , Villalba Sara , Tapias Elmy , Jaller Rodolfo , Segura Ana , Reyes Gloria , Potts James , Garcia-Larsen Vanessa
Published: June 2015

Background: Diet might influence the risk of allergic diseases. Evidence from developing countries with high prevalence of childhood asthma is scant. Methods: Information on wheeze, rhinitis, and eczema was collected from 3209 children aged 6–7 years in 2005, who were taking part in the International Study on Asthma and Allergy in Children (ISAAC) in Colombia. Intake frequency of twelve food groups was assessed. Associations between each food group and current wheeze, rhino-conjunctivitis, and eczema were investigated with multiple logistic regressions, adjusting for potential confounders. Simes’ procedure was used to test for multiple comparisons. Results: 14.9% of children reported wheeze in the last 12 months, 16% rhino-conjunctivitis, and 22% eczema. Eczema was negatively associated with consumption of fresh fruits and pulses three or more times per week (adjusted Odds ratio (aOR): 0.64; 95% Confidence Interval (CI): 0.49 to 0.83; p value = 0.004; and aOR: 0.62, 95% CI: 0.47 to 0.80; p value < 0.001, respectively). Current wheeze was negatively associated with intake of potatoes (aOR: 0.44, 95% CI: 0.31 to 0.62, p value = 0.005), whilst this outcome was positively associated with consumption of fast food (aOR: 1.76, 95% CI: 1.32 to 2.35, p value = 0.001). These associations remained statistically significant after controlling for multiple comparisons. Conclusions: A traditional diet might have a protective effect against eczema and wheeze in Colombian children, whilst intake of fast foods increases this risk.
Creating a Distinct Medication-Use System for Children at the Point of Care: The Time is Now
Authors: II Richard , Cernak Ibolja
Published: June 2015

Children need a distinct medicines-use system designed explicitly for them since their continued inclusion in a system of prescription processing developed for adults generates insoluble risk points and workarounds. The American Academy of Pediatrics (AAP), in its policy statement released by the AAP Committee on Drugs in early 2014 about off-label use in children, posits that federal legislation on increased drug testing in children has been effective, as “there have been over 500 pediatric-specific labeling changes.” However, the AAP’s position has not changed materially since the original 2002 policy statement. Indeed, other health professionals, their organizations, or affiliated practice-based research network (PBRNs) mechanisms continue to be excluded from consideration, collaboration, or even honorable mention. It is noteworthy that most of the 500 labeling changes made since 1997 have addressed the scientific validity of indications for medication use in pediatric population without regard to pharmacotherapy formulation or monitoring. Medication use in children continues to be associated with an unacceptably high rate of adverse events, morbidity, and death. Children should no longer be “shoehorned” into the adult medication-use system, which faces challenges in addressing even the adult population’s needs. The time is now to design a multi-phasic, systematic approach to the pharmacotherapy of children. This paper will argue for the establishment of a distinct medication use system for children, a trans-disciplinary system designed thoughtfully and intentionally, not by convention, consensus, or imitation.
The Effects of Solvent and Added Bases on the Protection of Benzylamines with Carbon Dioxide
Authors: Ethier Amy , Switzer Jackson , Rumple Amber , Medina-Ramos Wilmarie , Li Zhao , Fisk Jason , Holden Bruce , Gelbaum Leslie , Pollet Pamela , Eckert Charles , Liotta Charles
Published: June 2015

The introduction and removal of protecting groups is ubiquitous in multi-step synthetic schemes. From a green chemistry standpoint, however, alternative strategies that employ in situ and reversible protection and deprotection sequences would be attractive. The reversible reactions of CO2 with amines could provide a possible vehicle for realizing this strategy. Herein, we present (1) the products of reaction of benzylamines with CO2 in a variety of solvents with and without the presence of basic additives; (2) new adducts associated with CO2 protected benzylamine in acetonitrile containing 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU); and (3) the intermolecular competitive acylation of benzylamine and benzyl alcohol and the intramolecular competitive acylation of (4-aminomethyl)phenyl) methanol with isopropenyl acetate in acetonitrile containing DBU in the absence and presence of CO2.
Interpretation of Illness in Patients with Chronic Diseases from Poland and Their Associations with Spirituality, Life Satisfaction, and Escape from Illness—Results from a Cross Sectional Study
Authors: Büssing Arndt , Surzykiewicz Janusz
Published: June 2015

To analyse how patients with chronic diseases would interpret their illness, and how these interpretations were related to spirituality/religiosity, life satisfaction, and escape from illness, we performed a cross-sectional survey among patients with chronic diseases from Poland (n = 275) using standardized questionnaires. Illness was interpreted mostly as an Adverse Interruption of life (61%), Threat/Enemy (50%), Challenge (42%), and rarely as a Punishment (8%). Regression analyses revealed that escape from illness was the best predictor of negative disease perceptions and also strategy associated disease perceptions, and a negative predictor of illness as something of Value, while Value was predicted best by specific spiritual issues. Patients’ religious Trust and partner status were among the significant contributors to their life satisfaction. Data show that specific dimensions of spirituality are important predictors for patients’ interpretation of illness. Particularly the fatalistic negative perceptions could be indicators that patients may require further psychological assistance to cope with their burden.
Stakeholder Perceptions of Unit Based Waste Disposal Schemes in Ontario, Canada
Authors: Lakhan Calvin
Published: June 2015

This study examines stakeholder perceptions of pay as you throw schemes (PAYT) in Ontario, Canada. Using a combination of panel and semi-structured survey data from provincial municipalities, focus is placed on analyzing: (a) the effects of PAYT systems on municipal recycling rates and program costs (b) stakeholder perceptions on the perceived effectiveness of PAYT policy (c) how locality affects PAYT program costs and affect municipal recycling rates and (d) the impact of Ontario’s “one Blue Box per household” provision on PAYT schemes. The results of the analysis show that while the implementation of PAYT schemes do increase municipal recycling rates, there are opportunities for further improvement. In Ontario, the effectiveness of PAYT policy is impaired by inconsistent enforcement, administrative burden, and the inadequate capacity of household recycling bins (“blue bins”).
StaMPS Improvement for Deformation Analysis in Mountainous Regions: Implications for the Damavand Volcano and Mosha Fault in Alborz
Authors: Vajedian Sanaz , Motagh Mahdi , Nilfouroushan Faramarz
Published: June 2015

Interferometric Synthetic Aperture Radar (InSAR) capability to detect slow deformation over terrain areas is limited by temporal decorrelation, geometric decorrelation and atmospheric artefacts. Multitemporal InSAR methods such as Persistent Scatterer (PS-InSAR) and Small Baseline Subset (SBAS) have been developed to deal with various aspects of decorrelation and atmospheric problems affecting InSAR observations. Nevertheless, the applicability of both PS-InSAR and SBAS in mountainous regions is still challenging. Correct phase unwrapping in both methods is hampered due to geometric decorrelation in particular when using C-band SAR data for deformation analysis. In this paper, we build upon the SBAS method implemented in StaMPS software and improved the technique, here called ISBAS, to assess tectonic and volcanic deformation in the center of the Alborz Mountains in Iran using both Envisat and ALOS SAR data. We modify several aspects within the chain of the processing including: filtering prior to phase unwrapping, topographic correction within three-dimensional phase unwrapping, reducing the atmospheric noise with the help of additional GPS data, and removing the ramp caused by ionosphere turbulence and/or orbit errors to better estimate crustal deformation in this tectonically active region. Topographic correction is done within the three-dimensional unwrapping in order to improve the phase unwrapping process, which is in contrast to previous methods in which DEM error is estimated before/after phase unwrapping. Our experiments show that our improved SBAS approach is able to better characterize the tectonic and volcanic deformation in the center of the Alborz region than the classical SBAS. In particular, Damavand volcano shows an average uplift rate of about 3 mm/year in the year 2003–2010. The Mosha fault illustrates left-lateral motion that could be explained with a fault that is locked up to 17–18 km depths and slips with 2–4 mm/year below that depth.
Fostering Sustainable Energy Entrepreneurship among Students: The Business Oriented Technological System Analysis (BOTSA) Program at Eindhoven University of Technology
Authors: Wijnker Mara , Van Kasteren Han , Romijn Henny
Published: June 2015

The Business Oriented Technological System Analysis (BOTSA) program is a new teaching and learning concept developed by Eindhoven University of Technology (the Netherlands) with participation from innovative companies in renewable energy. It is designed to stimulate sustainable entrepreneurship among engineering students in this field. The program combines the placement of students in companies to study and contribute to the development and incubation of sustainable energy innovations, with a curriculum at the university designed to support these internships from a scientific perspective. The teaching method assists students in developing a broad system view that enables them to analyze the potential of, and bottlenecks to promising innovations from a realistic business perspective. This empowers students to identify those techno-economic aspects that are critical to innovation success, and advise the entrepreneurs about these aspects. Experience indicates that teachers, students, and entrepreneurs find BOTSA a valuable way of coaching, learning and working. Theoretical support for this method is found in system analysis originating in evolutionary innovation theory in combination with concepts of entrepreneurship, business model generation and sustainable/green innovation.
Attitudes of Citizens towards Urban Parks and Green Spaces for Urban Sustainability: The Case of Gyeongsan City, Republic of Korea
Authors: Lee Young-Chang , Kim Keun-Ho
Published: June 2015

Urban parks and green spaces support a wide array of species and play an important role in long-term sustainability. This study analyzed the needs and attitudes of citizens towards urban parks and green spaces in order to provide information for setting the future direction of urban sustainability to maximize quality of life. A questionnaire survey was conducted to analyze the general characteristics of respondents and their awareness of parks and spaces. First, the results indicate that the main purpose of visiting parks was relaxation and walking. Second, the type of parks visited most frequently by the respondents was pocket parks around home. Third, the main reason for going to the frequently visited parks was “close to home”. Fourth, the major reason for visiting parks infrequently was “improper park management”. Fifth, the desired types of urban parks were relaxation parks close to natural rivers. Sixth, citizens wanted to participate in the expansion projects of parks and green spaces through non-profit civic organizations or volunteer activities. Further research with a comparative analysis among different cities will be necessary to generalize Korean attitudes to urban parks and green spaces for urban sustainability.
Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge
Authors: Devera T. , Prusator Dawn , Joshi Sunil , Ballard Jimmy , Lang Mark
Published: June 2015

Protective immunity against anthrax is inferred from measurement of vaccine antigen-specific neutralizing antibody titers in serum samples. In animal models, in vivo challenges with toxin and/or spores can also be performed. However, neither of these approaches considers toxin-induced damage to specific organ systems. It is therefore important to determine to what extent anthrax vaccines and existing or candidate adjuvants can provide organ-specific protection against intoxication. We therefore compared the ability of Alum, CpG DNA and the CD1d ligand α-galactosylceramide (αGC) to enhance protective antigen-specific antibody titers, to protect mice against challenge with lethal toxin, and to block cardiotoxicity and hepatotoxicity. By measurement of serum cardiac Troponin I (cTnI), and hepatic alanine aminotransferase (ALT), and aspartate aminotransferase (AST), it was apparent that neither vaccine modality prevented hepatic intoxication, despite high Ab titers and ultimate survival of the subject. In contrast, cardiotoxicity was greatly diminished by prior immunization. This shows that a vaccine that confers survival following toxin exposure may still have an associated morbidity. We propose that organ-specific intoxication should be monitored routinely during research into new vaccine modalities.
Spatial Distribution of Field Physico-Chemical Parameters in the Vulcano Island (Italy) Coastal Aquifer: Volcanological and Hydrogeological Implications
Authors: Madonia Paolo , Capasso Giorgio , Favara Rocco , Francofonte Salvatore , Tommasi Paolo
Published: June 2015

Vulcano, the southernmost of the Aeolian island arc (Italy), is characterized by a shallow coastal aquifer resulting from the mixing of seawater, meteoric recharge and volcanogenic fluids. The aquifer has been intensively studied during the last decades, but a comprehensive hydrogeological model has never been developed due to the lack of direct information about the litho-stratigraphic columns of the wells and the depth of water bearing levels. We present and discuss here the time and spatial analysis of water table elevation, temperature and electric conductivity data, acquired during the last 20 years in 33 wells located at Vulcano Island, with the aim of developing a groundwater circulation scheme able to fit the field observations. We retrieved a circulation scheme characterized by an intricate geometry of flow paths driven by horizontal and vertical permeability variations, accounting for the strong variability of geochemical data evidenced in this area by the related scientific literature. Extending these results to a general context, particular care must be taken in approaching the study of aquifers in volcanic islands, because a strong, small spatial scale variability of the hydrogeochemical parameters is expected, and a reliable knowledge of the local conditions is required for developing successful groundwater circulation schemes.
Analysis of Clinical Cohort Data Using Nested Case-control and Case-cohort Sampling Designs
Authors: Wolkewitz M. , Beyersmann J. , Palomar-Martinez M. , Olaechea-Astigarraga P. , Alvarez-Lerma F. , Schumacher M. , Ohneberg K.
Published: June 2015

Background: Sampling from a large cohort in order to derive a subsample that would be sufficient for statistical analysis is a frequently used method for handling large data sets in epidemiological studies with limited resources for exposure measurement. For clinical studies however, when interest is in the influence of a potential risk factor, cohort studies are often the first choice with all individuals entering the analysis.

Objectives: Our aim is to close the gap between epidemiological and clinical studies with respect to design and power considerations. Schoenfeld’s formula for the number of events required for a Cox’ proportional hazards model is fundamental. Our objective is to compare the power of analyzing the full cohort and the power of a nested case- control and a case-cohort design.

Methods: We compare formulas for power for sampling designs and cohort studies. In our data example we simultaneously apply a nested case-control design with a varying number of controls matched to each case, a case cohort design with varying subcohort size, a random subsample and a full cohort analysis. For each design we calculate the standard error for estimated regression coefficients and the mean number of distinct persons, for whom covariate information is required.

Results: The formula for the power of a nested case-control design and the power of a case-cohort design is directly connected to the power of a cohort study using the well known Schoenfeld formula. The loss in precision of parameter estimates is relatively small compared to the saving in resources.

Conclusions: Nested case-control and case-cohort studies, but not random subsamples yield an attractive alternative for analyzing clinical studies in the situation of a low event rate. Power calculations can be conducted straightforwardly to quantify the loss of power compared to the savings in the number of patients using a sampling design instead of analyzing the full cohort.
Peptide-equipped tobacco mosaic virus templates for selective and controllable biomineral deposition
Authors: Altintoprak Klara , Seidenstücker Axel , Welle Alexander , Eiben Sabine , Atanasova Petia , Stitz Nina , Plettl Alfred , Bill Joachim , Gliemann Hartmut , Jeske Holger , Rothenstein Dirk , Geiger Fania , Wege Christina
Published: June 2015

The coating of regular-shaped, readily available nanorod biotemplates with inorganic compounds has attracted increasing interest during recent years. The goal is an effective, bioinspired fabrication of fiber-reinforced composites and robust, miniaturized technical devices. Major challenges in the synthesis of applicable mineralized nanorods lie in selectivity and adjustability of the inorganic material deposited on the biological, rod-shaped backbones, with respect to thickness and surface profile of the resulting coating, as well as the avoidance of aggregation into extended superstructures. Nanotubular tobacco mosaic virus (TMV) templates have proved particularly suitable towards this goal: Their multivalent protein coating can be modified by high-surface-density conjugation of peptides, inducing and governing silica deposition from precursor solutions in vitro. In this study, TMV has been equipped with mineralization-directing peptides designed to yield silica coatings in a reliable and predictable manner via precipitation from tetraethoxysilane (TEOS) precursors. Three peptide groups were compared regarding their influence on silica polymerization: (i) two peptide variants with alternating basic and acidic residues, i.e. lysine–aspartic acid (KD)x motifs expected to act as charge-relay systems promoting TEOS hydrolysis and silica polymerization; (ii) a tetrahistidine-exposing polypeptide (CA4H4) known to induce silicification due to the positive charge of its clustered imidazole side chains; and (iii) two peptides with high ZnO binding affinity. Differential effects on the mineralization of the TMV surface were demonstrated, where a (KD)x charge-relay peptide (designed in this study) led to the most reproducible and selective silica deposition. A homogenous coating of the biotemplate and tight control of shell thickness were achieved.
Characteristics of Pediatric Performance on a Test Battery Commonly Used in the Diagnosis of Central Auditory Processing Disorder
Authors: Weihing Jeffrey , Guenette Linda , Chermak Gail , Brown Mallory , Ceruti Julianne , Fitzgerald Krista , Geissler Kristin , Gonzalez Jennifer , Brenneman Lauren , Musiek Frank
Published: June 2015

Background:Although central auditory processing disorder (CAPD) test battery performance has been examined in adults with neurologic lesions of the central auditory nervous system (CANS), similar data on children being referred for CAPD evaluations are sparse.Purpose:This
study characterizes CAPD test battery performance in children using tests commonly administered to diagnose the disorder. Specifically, this study describes failure rates for various test combinations, relationships between CAPD tests used in the battery, and the influence of cognitive function
on CAPD test performance and CAPD diagnosis. A comparison is also made between the performance of children with CAPD and data from patients with neurologic lesions of the CANS.Research Design:A retrospective study.Study Sample:Fifty-six pediatric patients were referred for CAPD
testing.Data Collection and Analysis:Participants were administered four CAPD tests, including frequency patterns (FP), low-pass filtered speech (LPFS), dichotic digits (DD), and competing sentences (CS). In addition, they were given the Wechsler Intelligence Scale for Children (WISC).
Descriptive analyses examined the failure rates of various test combinations, as well as how often children with CAPD failed certain combinations when compared with adults with CANS lesions. A principal components analysis was performed to examine interrelationships between tests. Correlations
and regressions were conducted to determine the relationship between CAPD test performance and the WISC.Results:Results showed that the FP and LPFS tests were most commonly failed by children with CAPD. Two-test combinations that included one or both of these two tests and excluded
DD tended to be failed more often. Including the DD and CS test in a battery benefited specificity. Tests thought to measure interhemispheric transfer tended to be correlated. Compared with adult patients with neurologic lesions, children with CAPD tended to fail LPFS more frequently and DD
less frequently. Both groups failed FP with relatively equal frequency.Conclusions:The two-test combination that showed the highest failure rate for children with CAPD was LPFS-FP. Comparison with adults with CANS lesions, however, suggests that the mechanisms underlying LPFS performance
in children need to be better understood. The two-test combination that showed the next highest failure rates among children with CAPD and did not include LPFS was CS-FP. If it is desirable to use a dichotic measure that has a lower linguistic load than CS then DD can be substituted for CS
despite the slightly lower failure rate of the DD-FP battery.
AERODYNAMIC RESISTANCE OF A BIOFILTER WITH A PACKING OF PINE CONES
Authors: MITIN Aleksandr , NIKOLAJKINA Natalya , PUSHNOV Aleksandr
Published: June 2015

The results of experiments on practical suitability of a biofilter packing made of natural materials – pinecones are provided. Geometric characteristics of a random packing of pine cones are calculated and compared with other types of packings of artificial and natural materials. Aerodynamic tests of the packing are carried out and obtained data are compared with the data for other packings. Some recommendations on improving the performance characteristics of the packing are suggested.
STUDY OF DEPENDENCE BETWEEN CLAY MINERAL DISTRIBUTION AND SHALE VOLUME IN RESERVOIR ROCKS USING GEOSTATISTICAL AND PETROPHYSICAL METHODS
Authors: Abdideh Mohammad
Published: June 2015

Identify and obtain a detailed understanding of shale and its clay minerals in three segments; exploration, drilling and reservoir in the oil industry are very important. The study of the formation clay minerals in terms of depth and layers of earth is done through X-ray tests on samples taken from the reservoir which in comparison with logging requires a lot more time and cost and also can't provide continuous results because continuous sampling from the whole well is not possible. NGS (Gamma-ray Spectrometry) log is used to identify formation clay minerals that is an indicator of three radioactive elements thorium, uranium and potassium and the amount of each of these elements and according to amount of each of these elements and their ratio gives a description of clay minerals of each zone. CGR log represents the sum of two elements Thorium and potassium that are present in the shale and uranium has no effect on it. The CGR log is usually used as a shale indicator and it is an essential tool for determining the Shale volume in well logging operation. In this study the relationship between shale volume shown by the CGR log and the type of formation clay mineral was investigated. A very clear relationship between the shale volume and formation clay minerals was observed. In intervals with low shale volume the amount of active clay minerals, especially montmorillonite was higher and in intervals with high shale volume, inactive clay minerals were more. In order to investigate the spatial relation between the logging data, frequency distribution and correlation between logging data was studied. By using logging data and identifying the type of clay minerals in each zone and also the spatial correlation between logging data a suitable program for drilling and exploitation of oil fields in different areas can be proposed.
A COMPARISON STUDY BETWEEN COLLINEARITY CONDITION, COPLANARITY CONDITION, AND DIRECT LINEAR TRANSFORMATION (DLT) METHOD FOR CAMERA EXTERIOR ORIENTATION PARAMETERS DETERMINATION
Authors: El-Ashmawy Khalid L. A.
Published: June 2015

The present work emphasizes on using collinearity condition, coplanarity condition and DLT method for determining the camera exterior orientation parameters. The derivation of the mathematical formulation based on each suggested methods is explained. The comparison of the results of the methods was performed based on accuracy aspects using mathematical and actual photogrammetric data. The used data shows that the suggested methods are suitable for camera exterior orientation parameters determination for a block of photographs of any size. The results of this investigation prove that the accuracy of using coplanarity equations is slightly better than using collinearity equations or DLT method. Although the results of the DLT method are less accurate than those of using collinearity or coplanarity equation, DLT method is essential when the necessary information for the collinearity or coplanarity model is not available. This paper shows the necessity for the mathematical photogrammetric data for testing the photogrammetric studies.
FUZZY SPATIAL ASSOCIATION RULE MINING TO ANALYZE THE EFFECT OF ENVIRONMENTAL VARIABLES ON THE RISK OF ALLERGIC ASTHMA PREVALENCE
Authors: Sadat Yousef Kanani , Nikaein Tina , Karimipour Farid
Published: June 2015

The prevalence of allergic diseases has greatly increased in recent decades, likely due to contamination of the environment with allergy irritants. One common treatment is identifying that allergy irritant, and then avoiding exposure to it. This article studies the relation between the prevalence of allergic asthma and certain allergy irritants that are related to environmental variables. To that end, we use spatial association rule mining to determine the association between the spatial distribution of allergic asthma prevalence and air pollutants such as CO, SO2, NO2, PM10, PM2.5, and O3 (from data compiled by air pollution monitoring stations), as well as other factors, such as the distance of residence from parks and roads. In order to clear up the uncertainties inherent in the attributes linked to the spatial data, the dimensions in question have been defined as fuzzy sets. Results for the case study (i.e. Tehran metropolitan area) indicate that distance to parks and roads, as well as CO, NO2, PM10, and PM2.5 levels are related to allergic asthma prevalence, while SO2 and O3 are not. Finally, we use the extracted association rules in fuzzy inference system to produce the spatial risk map of allergic asthma prevalence, which shows how much is the risk of allergic asthma prevalence at each point of the city.
RCM and AHP hybrid model for road network maintenance prioritization
Authors: Orugbo Ena E. , Alkali Babakalli M. , DeSilva Anjali , Harrison David K.
Published: June 2015

Category1 defects such as potholes significantly accelerate structural deterioration and pose imminent hazards on trunk road networks. Frequent occurrences of category1 defects have increased service disruptions on trunk road networks. Road maintenance agencies are now required to effectively prioritize trunk road network category1 defects maintenance works. However, existing road maintenance prioritization methods such as value engineering and traditional expert judgment methods have limitations. Value engineering is resource and time intensive thus best suited for project level prioritization and traditional expert judgments are subjective and lack audit trails. In an attempt to address the limitations of above methods, this study presents a Reliability Centered Maintenance and Analytical Hierarchy Process based hybrid model for trunk road network maintenance prioritization. The proposed hybrid model is used to establish failure diagnostic and Multi-criteria Decision Making respectively. As a case study, the hybrid model is implemented on a trunk road network in the United Kingdom. Relevant category1 defect failure information linked to trunk road network subassets are extracted from databases and relevant information elicited from maintenance experts. The criticality analysis results presented show the risk priority numbers of category1 defect related failures and cost effective preventative maintenance tasks are proposed. The Analytical Hierarchy Process results are used to address the complex prioritization process. The proposed hybrid model facilitates a systematic prioritization of a large number of trunk road network category1 defect failure maintenance activities consistently.