bluuebunny/crossref_metadata_2025 huggingface dataset:
The impacts of sarcopenia on outcomes of patients with left-sided colon or rectal cancer after curative surgery
Authors: Li Qi , An Tailai , Wu Jianbin , Lu Weiqi , Wang Yan , Li Jia , Yang Lina , Chen Yiqi , Lin Lizhu , Yang Zhenjiang
Published: February 2023

Background
The impacts of nutritional status on and short-term and long-term survival of patients with left-sided colon or rectal cancer have not been exhaustively investigated. Thus, we accomplished the present study to evaluate the effects of sarcopenia on short-term and long-term outcomes of patients with left-sided colon or rectal cancer.
Methods
Patients with pathologically diagnosed stage I, II and III left-sided colon or rectal cancer who had undergone curative surgery were studied. The psoas muscle index (PMI) identified by 3D-image analysis of computed tomographic images was the criterion used to diagnose sarcopenia. The cutoff value recommended by Hamaguchi et al. (PMI value < 6.36 cm2/m2 for men and < 3.92 cm2/m2 for women) was adopted to confirm the diagnosis of sarcopenia. According to PMI, each patient was divided into the sarcopenia group (SG) or the non-sarcopenia group (NSG). Then SG was compared with NSG in terms of short-term outcomes and long-term outcomes.
Results
Among the 939 patients included, 574 ones (61.1%) were confirmed with preoperative sarcopenia. Initially, it was demonstrated that SG was not significantly different from NSG in terms of most baseline characteristics except smaller body mass index (BMI) (P < 0.001), larger tumor size (P < 0.001) and more weight loss (P = 0.029). Then it revealed that SG had a longer hospital stay after surgery (P = 0.040), more intraoperative blood transfusion (P = 0.035), and a higher incidence of anastomotic fistula (P = 0.027), incision infection (P = 0.037) and hypoalbuminemia (P = 0.022). The SG had significantly worse overall survival (OS) (P = 0.016) and recurrence-free survival (RFS) (P = 0.036) than the NSG. Subsequently, by Cox regression analysis, we revealed that preoperative sarcopenia was an independent predictive factor for worse OS (P = 0.0211, HR = 1.367, 95%CI: 1.049–1.782) and RFS (P = 0.045, HR = 1.299, 95%CI: 1.006–1.677).
Conclusion
Preoperative sarcopenia significantly adversely affected long-term and short-term outcomes of patients with left-sided colon or rectal cancer and preoperative nutrition supplementation may help us improve their long-term and short-term outcomes.
Opto-E-cadherin: Optogenetic control over cell-cell adhesions
Authors: Mombo Brice Nzigou , Bijonowski Brent , Niland Stephan , Brockhaus Katrin , Müller Marc , Eble Johannes , Wegner Seraphine
Published: February 2023

E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many essential processes, including embryogenesis, wound healing and tissue organization, with dysregulation manifesting as tumorigenesis and metastasis. However, the lack of tools that would provide control of the high spatiotemporal precision observed with E-cadherin adhesions hampers investigation of the underlying mechanisms. Here, we present an optogenetic tool, opto-E-cadherin, that allows reversible control of E-cadherin-mediated cell-cell adhesions with blue light. With opto-E-cadherin, functionally essential calcium binding is photoregulated such that cells expressing opto-E-cadherin at their surface adhere to each other in the dark but not upon illumination. Consequently, opto-E-cadherin provides remote control over multicellular aggregation, E-cadherin-associated intracellular signalling and F-actin organization in 2D and 3D cell cultures. Opto-E-cadherin also allows switching of multicellular behaviour between single and collective cell migration, as well as of cell invasiveness in vitro and in vivo. Overall, opto-E-cadherin is a powerful optogenetic tool capable of controlling cell-cell adhesions at the molecular, cellular and behavioural level that opens up perspectives for the study of dynamics and spatiotemporal control of E-cadherin in biological processes.
Effect of Titanium-Dioxide nanoparticle on Richardson Constant and Barrier Height of Tartrazine Dye based Schottky Device
Authors: Karan Arnab Kanti , Sahoo Dipankar , Sen Sudipta , Rakshit Subhra , Manik Nabin Baran
Published: February 2023

Recently Fruit Dyes have achieved a significant interest as organic devices because of they are widely available, customizable and biodegradable. But low conductivity is one of the major limitations. Low conductivity is due to low charge injection from the electrodes to the organic layer and the charge injection process is strongly dependent on the injection barrier height at the metal-dye interface. Higher barrier height causes low charge injection. A detailed analysis is needed to reduce the interfacial barrier to get better conductivity. In this work, we have estimated the interfacial barrier height of Indium tin oxide coated glass/Tartrazine dye/Copper based device with and without titanium dioxide nanoparticles. The devices have been prepared with dye and dye-nanoparticles blends by using the spin coating technique. We have measured the steady state dark current-voltage-temperature characteristics in the range of 288 K to 333 K to estimate the Richardson constant and interfacial barrier height. The Richardson constant was found to be modified from 44.35×10-3 to 07.34×10-2 Am-2K-2. We also have found that interfacial barrier height is reduced from 0.71 eV to 0.64 eV in the presence of nanoparticles at room temperature. As the temperature increased, the interfacial barrier height increased to 0.72 eV from 0.71 eV and to 0.68 eV from 0.62 eV for dye based device with and without nanoparticles, respectively. Reduction of the interfacial barrier height indicates an increase in the charge injection through the interface. This work will be informative to improve the charge flow at the metal–fruit dye interface.
Development of Spectinabilin Over-Producing Mutant Streptomyces sp. S-N87 having Nematicidal Activities
Authors: Kang Min-Kyoung , Kim Jong-Hoon , Moon Kyung Ho , Jeong Hyeon Ji , Lee Byeong Min , Sung Bong Hyun , Park Dong-Jin , Son Kwang-Hee
Published: February 2023

Spectinabilin (neoaureothin) is a rare nitrophenyl-substituted polyketide produced by some Streptomyces species. This compound is known to exhibit various biological activities such as anticancer, antibiotic, immunomodulatory, antimalarial and nematicidal effects. Despite being a valuable secondary metabolite for the development of novel drugs, the production yield of spectinabilin is < 200 mg/litre at the current level. To improve the yields of this promising compound without biosafety and regulation issues, this study conducted traditional mutagenesis. A total of 1,025 mutants were generated under high mortality conditions by NTG (N-methyl-N’-nitro-N-nitrosoguanidine) from parental strain Streptomyces sp. AN091965. One of the mutants, S-N87 showed up to about 10-fold spectinabilin productivity (354.8 ± 7.8 mg/L) compared to the parental strain Streptomyces sp. AN091965 (37.6 ± 5.6 mg/L) in flask culture conditions, representing the highest spectinabilin yield reported thus far. In addition, this strain showed a stable yield of 2.27 g/L even in a scaled-up environment (150 L tank fermentation), which suggests that the selected mutant is a genetically stable and robust strain. Further, the mutant Streptomyces sp. S-N87 that enhanced spectinabilin production stably showed a significant increase in nematicidal activities against pine wilt nematode compared to the parental strain. The present study is the first to develop a Streptomyces mutant that over-produces spectinabilin by traditional mutagenesis. Further studies such as whole-genome analysis and genetic modification are needed to provide a theoretical basis and insights into the polyketide synthase pathway of this talented mutant.
Efficacy of tapering (STEP down) therapy using vonoprazan for symptomatic mild reflux esophagitis
Authors: Ochiai Yorinari , Kikuchi Daisuke , Hoteya Shu
Published: February 2023

Aim: This study aimed to elucidate the efficacy of tapering (STEP down) therapy based on patients’ symptoms using vonoprazan (VPZ) for symptomatic mild reflux esophagitis (RE).
Methods: Sixty-three consecutive symptomatic patients with mild RE were enrolled in this study. STEP down therapy was defined as a treatment period of 28 days. VPZ (20 mg) was administered as initial treatment. Patients were allowed to step down to 10 mg VPZ if their symptoms improved, and may discontinue VPZ if their symptoms disappeared. When symptoms worsened, dosage could be increased from 10 mg to 20 mg VPZ, or VPZ restarted at 20 mg following discontinuation.
Results: The proportion of the patients whose FSSG scores decreased by three points or more with STEP down therapy was 76.2% (48/63 patients). The median FSSG scores before and after STEP down therapy were 13 (8–35) and 7 (0–29) points, respectively (p<0.01). Overall, 71.4% (45/63) of patients stepped down from 20 mg to 10 mg VPZ, and 46% (29/63) of patients discontinued VPZ.
Conclusion: STEP down therapy with VPZ may be a viable treatment option in symptomatic patients
with mild RE.
Investigating the Sustainability of River Bank Filtration in Iraq
Authors: Ghanim Adnan D. , Eltoukhy Mahmoud A R. , El-Serafy Sonia Y. , Mohamed Elzahry F.
Published: February 2023

In the framework ofRiverBankFiltration "RBF" applicability to confront Iraq water crises, this investigation was originated with the impartial of investigating its sustainability in Iraq. Principally, literature was reviewed in the field of RBF sustainability. 2 previous research results of a sampling campaign in November 2021, were implemented; Adnan et al. (2022a) and (2022b). They verified RBF applicability against Iraqi Standards and validated its applicability against International Standards, respectively. Accordingly, in this research, extensive fieldwork was executed, where site visits were carried out along Tigris River; the available wells were inspected and 5 sampling campaigns were undergone periodically, in December 2021, March 2022, April 2022, July 2022 and August 2022. This was achieved to consider Iraq seasonality. The samples result of the 5 campaigns were analyzed; plotted on graphs and compared to the results of Adnan et al. (2022a). The analyzed results and comparison emphasized the sustainability of RBF applicability in Iraq, which would, most probably contribute in solving its water conflict crisis.
Transcatheter arterial embolization for acute lower gastrointestinal bleeding using imipenem/cilastatin: A single-center retrospective study
Authors: Hiraki Sakiko , Sato Fumie , Osugi Masaya , Watanabe Yoshiya , Ichinose Yoshiaki
Published: February 2023

Background: Transcatheter arterial embolization (TAE) is a standard treatment for acute lower gastrointestinal bleeding (LGIB) in situations where endoscopic approaches are impossible or ineffective. Various embolic materials, such as metallic coils and N-butyl cyanoacrylate, are used. This study aimed to evaluate the clinical outcomes of an imipenem/cilastatin (IPM/CS) mixture as an embolic agent in TAE for acute LGIB.
Results: Twelve patients (mean age, 67 years) with LGIB treated with TAE using IPM/CS were retrospectively evaluated between February 2014 and September 2022. All patients showed evidence of extravasation on computed tomography and 50% (6/12) also showed evidence on angiography. The technical success rate for TAE in this study was 100%, including in patients who showed active extravasation on angiography. The clinical success rate was 83.3% (10/12), with two patients experiencing re-bleeding within 24 h after the procedure. No ischemic complications were observed and no bleeding episodes or other complications were reported during the follow-up period.
Conclusions: This study revealed that using IPM/CS as an embolic agent in TAE for acute LGIB may be safe and effective, even in cases of active bleeding.
Genomic analysis and filtration of novel prognostic biomarkers based on metabolic and immune subtypes in pancreatic cancer
Authors: Chen Guangyu , Liu Yueze , Su Dan , Qiu Jiangdong , Long Junyu , Zhao Fangyu , Tao Jinxin , Yang Gang , Huang Hua , Xiao Jianchun , Zhang Taiping , Zhao Yupei
Published: February 2023

An increasing number of studies have indicated that patients with pancreatic cancer (PC) can be classified into various molecular subtypes and benefit from some precise therapy. Nevertheless, the interaction between metabolic and immune subtypes in the tumor microenvironment (TME) remains unknown. Thus, we utilized unsupervised consensus clustering and ssGSEA analysis respectively to construct molecular subtypes related to metabolism and immunity. Meanwhile, diverse metabolic and immune subtypes were characterized by distinct prognoses and TME. Afterward, we filtrated the overlapped genes based on the differentially expressed genes (DEGs) between the metabolic and immune subtypes by lasso regression and Cox regression, and used them to build risk score signature which led to PC patients was categorized into high- and low-risk groups. Furthermore, high-risk patients have a better response for various chemotherapeutic drugs in the Genomics of Drug Sensitivity in Cancer (GDSC) database. Finally, we built a nomogram with the risk group, age, and the number of positive lymph nodes to predict the survival rates of each PC patient with average 1-year, 2-year, and 3-year areas under the curve (AUCs) equal to 0.792, 0.752, and 0.751. In summary, the risk score signature based on the metabolism and immune molecular subtypes can accurately predict the prognosis and guide treatments of PC, meanwhile, the metabolism-immune biomarkers may provide novel target therapy for PC.
Title: Risk factors for non-infectious diarrhea of patients with multiple myeloma after chimeric antigen receptor T-cell immunotherapy: A retrospective observational study
Authors: Ding Shu-Yi , Cheng Yin , Huang Yi-Jie , Gao Xin , Yan Jia-Li , Wang Lin-Qin , Zhao Hou-Li , Wang Rui , Chen Sang-Sang , Teng Tian-Li , Liu Nian , Zhang Ming-Ming , Jin Ai-Yun , Hu Yong-Xian
Published: February 2023

Purpose
To ascertain the risk factors and prevalence of non-infectious diarrhea among participants with multiple myeloma who treated with chimeric antigen receptor T-cell immunotherapy.
Methods
This study enrolled 88 patients with multiple myeloma who received chimeric antigen receptor T-cell immunotherapy at one tertiary general hospital in China. Participants were categorized into diarrhea subgroup and non-diarrhea subgroup according to the occurrence of diarrhea. Demographic data and self-reported measurements and planning were obtained from questionnaires and clinical data from hospital databases.
Results
In total, 50 patients suffered from non-infectious diarrhea, with the prevalence of 56.8%. Multiple logistic regression analysis showed that severe cytokine release syndrome (OR = 5.980), underlying diseases (OR = 4.184), previous treatment lines ≥ 6 (OR = 6.292) were prominent hazardous factors for non-infectious diarrhea (p < 0.05).
Conclusion
The incidence rate of non-infectious diarrhea in patients with multiple myeloma after CAR-T therapy was at a high level. Severe cytokine release syndrome, previous treatment lines ≥ 6 and the underlying diseases were important predictors for non-infectious diarrhea. Medical staff should early evaluate these major factors to reduce the risk of diarrhea (184 words).
One year of experience with combined pharmacokinetic/pharmacogenetic monitoring of anti-TNF alpha agents: a retrospective study
Authors: Clementi Emilio , Cheli Stefania , Savino Diego , De Silvestri Annalisa , Norsa Lorenzo , Sansotta Naire , Penagini Francesca , Dilillo Dario , Panceri Roberto , Cattaneo Dario , Zuin Giovanna
Published: February 2023

Anti-tumor necrosis factor alpha (anti-TNFα) inhibitors are used extensively for the management of moderate to severe inflammatory bowel disease (IBD) in both adult and pediatric patients. Unfortunately, not all patients show optimal response to induction therapy, while others lose their response over time, for reasons yet poorly understood. We report on a pharmacokinetic/pharmacogenetic approach to monitor the therapy with anti-TNFα in a real-world cohort of seventy-nine pediatric patients affected by IBD that was analyzed retrospectively. We evaluated serum concentrations of infliximab, adalimumab and related anti-drug antibodies (ADAs), and single nucleotide polymorphisms (SNPs) in genes involved in immune processes and inflammation on anti-TNFα response. We found a significant association between the SNP in TNFα promoter (-308G > A) and clinical remission without steroids in patients on infliximab therapy. Additionally, a potential connection between HLA-DQA1*05 genetic variant carriers and a higher risk of anti-TNFα immunogenicity emerged.
Common laboratory diets differentially influence zebrafish gut microbiome’s successional development and sensitivity to pathogen exposure
Authors: Sieler Michael , Al-Samarrie Colleen , Kasschau Kristin , Varga Zoltan , Kent Michael , Sharpton Thomas
Published: February 2023

Background: Despite the long-established importance of zebrafish (Danio rerio) as a model organism and their increasing use in microbiome-targeted studies, relatively little is known about how husbandry practices involving diet impact the zebrafish gut microbiome. Given the microbiome’s important role in mediating host physiology and the potential for diet to drive variation in microbiome composition, we sought to clarify how three different dietary formulations that are commonly used in zebrafish facilities impact the gut microbiome. We compared the composition of gut microbiomes in approximately 60 AB line adult (4- and 7-month-old) zebrafish fed each diet throughout their lifespan.
Results: Our analysis finds that diet has a substantial impact on the composition of the gut microbiome in adult fish, and that diet also impacts the developmental variation in the gut microbiome. We further evaluated whether the 7-month-old fish microbiome compositions that result from dietary variation are differentially sensitive to infection by a common laboratory pathogen, Mycobacterium chelonae. Our analysis finds that the gut microbiome’s sensitivity to M. chelonae infection varies as a function of diet, especially for moderate and low abundance taxa.
Conclusions: Overall, our results indicate that diet drives the successional development of the gut microbiome as well as its sensitivity to exogenous exposure. Consequently, investigators should carefully consider the role of diet in their microbiome zebrafish investigations, especially when integrating results across studies that vary by diet.
The Shared Decision-Making Tool for Caregivers of Children with Prenatal Opioid Exposure: A Pilot and Acceptability Study
Authors: Arter Sara , Bush Elsie , Clark Katie , Weber Stephanie
Published: February 2023

The purpose of this pilot study was to report initial findings about developmental concerns expressed by caregivers of children with prenatal opioid exposure using the Shared Decision-Making Tool, and to assess provider acceptability of incorporating the tool into their workflow. Data were collected from 83 caregivers and five providers from a medical clinic and an early intervention service center. Communication was the most frequently cited concern in four consecutive age categories. Inattention/impulsivity was the second most frequently cited concern in three consecutive age categories. Problem behavior was the third most frequently cited concern in three age categories. All providers ‘strongly agreed’ or ‘agreed’ with all statements on the provider feedback survey, except two instances. Data from this pilot study will guide our next research steps, focusing on psychometric testing and usability feedback from caregivers, before expanding trials of the Shared Decision-Making Tool to a wider geographic area. Findings from this pilot study will also inform the development of caregiver resources for managing areas identified as top concerns through the first five years of childhood.
Planning Distributed Security Operations Centers in Multi-Cloud Landscapes A Systematic Approach, Generalized from A Case Study
Authors: Schmidt Andreas U. , Knudsen Sven , Niehoff Tobias , Schwietz Klaus
Published: February 2023

We present a case study on the strategic planning of a security operations center in a typical, modern, mid-size organization. Against the backdrop of the company’s multi-cloud strategy a distributed approach envisioning the involvement of external providers is taken. From a security-centric abstraction of the organizational IT-landscape, a novel strategic planning method for security operation centers is developed with an adaptable relationship matrix as core tool. The method is put to a practical test in modeling different levels of engagement of external providers in the center’s operation. It is shown that concrete output, such as a core statement of work for an external provider, can easily be derived.
Hybrid DAER Based Cross-modal Retrieval Exploiting Deep Representation Learning
Authors: Huang Zhao , Hu Haowu
Published: February 2023

Information retrieval across multi-modal has attracted much attention from academics and practitioners. One key challenge of cross-modal retrieval is to eliminate the heterogeneous gap between different patterns. Most of the existing methods tend to jointly construct a common subspace. However, very little attention has been given to the study of the importance of different fine-grained regions of various modalities. This lack of considerations significantly influences the utilization of the extracted information of multiple modalities. Therefore, this study proposes a novel text-image cross-modal retrieval approach that constructs the dual attention network and the enhanced relation network (DAER). More specifically, the dual attention network tends to precisely extract fine-grained weight information from text and images, while the enhanced relation network is used to expand the differences between different categories of data in order to improve the computational accuracy of similarity. The comprehensive experimental results on three widely-used major datasets (i.e. Wikipedia, Pascal Sentence, and XMediaNet) show that our proposed approach is effective and superior to existing cross-modal retrieval methods.
An AI guided based vehicle control system for UMV
Authors: chaudhary kapil , NITIN NITIN CHAUDHARY
Published: February 2023

A novel methodology is proposed here for drivers commanding the vehicle through his gestures and haptic sensation that are connected to Master control system (MCS) which acts as an master interface between the driver and the different machinery sensors inside the vehicle, all such machinery is controlled by the respective actuators, that are commanded by the MCS correlated by the gesture, haptic sensation of driver. Inputs from vehicle i.e. surrounding situation and traffic positions are collected by HD video cameras placed at different positions on the vehicle hardware also the system is thoroughly by CDAS for better efficiency.This system has direct applications in situations where human life is very precious for example in serious conflicts ; also it counters the situation as faced by humanity during Covid19.
Ecofriendly and low cost CZTS absorber layer deposited by sol-gel for solar cell applications: Effect of copper concentration on physical properties
Authors: ZAKARIA Sanaa , MAHBOUB Elyazid EL , HICHOU Ahmed EL
Published: February 2023

Copper zinc tin sulfide (CZTS) thin films have been deposited by spin coating technique at various copper concentration ranging from 0.5M to 2.5M. The XRD patterns show the existence of the three main characteristic peaks of CZTS (112), (220) and (312), which indicate the formation of the kesterite structure of CZTS. Gap energy was calculated based on the derivation method using the absorbance data, and the values obtained vary from 1.46 eV to 1.58 eV depending on the copper molarities. Hall effect measurements were used to determine the conductivity, which in turn increased with the concentration of copper in the films. The results showed that the C3=1.5M exhibits higher crystallinity and better optical performance among the others. Finally, a theoretical efficiency of 11.6% was obtained by injecting the solar cell (CZTS/ZnS/S:ZnO) in SCAPS1D using the parameters obtained in this study. Under the adopted synthesis conditions, the theoretical simulation corroborated the experimental findings thus confirming that the synthesized material is a promising candidate for solar cell applications as an absorber layer.
Pastoralists Adaptation Strategies, and Resilience Capacity to Climate Change in Somalia: A Scoping Review
Authors: Ahmed Muse , Mohamed Mohamed Dahir , Muhammad Faisal
Published: February 2023

Pastoralism is a livelihood practice in which people earn a living by rearing livestock such as cattle, goats, sheep, donkeys, and camels, often in arid and semi-arid lands (ASALs). Over the last few decades, severe and frequent climate changes and variations have been observed. Notably, drought is a recurrent phenomenon in localities and has adverse impacts on people’s livelihood, an ecosystem of rangeland, natural resources, and social aspects as well livestock production. This review analyses livelihood vulnerability, coping mechanisms, and adaptation strategies of pastoral communities within the context of climate change in Somalia. This scoping review entails thoroughly searching published academic articles and grey literature via PUBMED, Google, and Google Scholar. All the results were summarized and reported. This review reported Mobility, Herd diversification, Livestock off-take, and an increasing number of drought-adapting livestock as adaptation strategies, whereas Herd splitting, Household splitting, Labor migration to town, and Charcoal and fuel-wood selling as coping strategies to drought. Emergency aid, veterinary services, safety net, and credit services were some of the drought response mechanisms given by NGOs and the government. It is also reported that drought response strategies desired by pastoralists were being constrained by inadequate capital of households, lack of affordable credit services, and conflicts. Significant indicators of vulnerability to climate variability include a decline of pasture lands, livestock death, water availability reduction, livestock products and prices, environmental degradation, food insecurity, and outbreaks of human and livestock diseases. Despite the effectiveness of Pastoralist knowledge, the pastoral traditional risk management and coping strategies have increasingly become ineffective and will not be viable and sustainable in the coming years due to several underlying causes, including climate variability and prolonged hazards, lack of proper livestock policies, absence of adequate investment and intervention to address chronic social problems, natural and environmental problems affecting pastoral production.
Kísérlet a roma népesség várható élettartamának meghatározására
Authors: Bálint Lajos
Published: February 2023

A roma népesség az egyik legsérülékenyebb, legrosszabb egészségi állapotú etnikai kisebbség Európában. Magyarországi élettartamuk meghatározása számos akadályba ütközik, nincsenek megbízható információnk arról kit tekintetünk romának és etnikai adatgyűjtés hiányában nem ismerjük az elhunytak nemzetiségi hovatartozását sem. A tanulmány a 2011. évi népszámlálási, a népszámláláson alapuló roma kötődésű népesség becsült adatai, ill. a népmozgalmi regiszterből származó halálozási és népességadatok segítségével, három különböző eljárás segítségével igyekezett megbecsülni a roma férfiak és nők várható élettartamát a 2010-es évek környékén. A roma többségű településeken (ahol a romák aránya meghaladta a 60%-ot) a férfiak várható élettartama 64,9, a nőké 70,8 év volt, míg az országos átlag a férfiaknál 71,2 év, a nőknél 78,7 volt. A romák által magasabb arányban lakott, térbeli klaszter eljárással meghatározott régiókban a férfiak élettartama nem sokban tért el az első eljárás eredményétől (65,7 év), míg a nőknél az országos átlaghoz közelibb értéket becsültünk (75,8 év). Végül, az iskolázottsági összetétel alapján számolt élettartam az egyes iskolázottsági csoportok korspecifikus rátáit súlyozta a roma népesség arányaival 20 éves kor felett, a fiatalabb korcsoportokra Brass relációs modellje segítségével becsülte a túlélők számát majd határozta meg a születéskor várható élettartamokat. E becslés szerint a roma férfiak várható élettartama 65,9, a nőké 74,0 év volt, előbbiek 5,4 évvel, utóbbiak 4,7 évvel maradtak el az időszakra hasonló módon számolt országos átlagtól (a férfiaknál: 71,3, a nőknél: 78,7). Az eljárások eredményei konzisztensnek bizonyultak a férfiaknál, eszerint a roma férfiak élettartama 5,3-6,3 évvel marad el az ország átlagától. A nőknél kapott eredmények – egy kivétellel – három és öt év közötti lemaradást jeleztek.
Kulcsszavak: roma népesség születéskor várható élettartama, roma népesség területi aránya, roma népesség iskolai végzettsége, roma többségű települések, népszámlálás, regiszter adatok.
Wetland water balance assessment: a case study of the Sosa wetland, Maseru, Lesotho
Authors: Mokhesuoe Fusi , Gumindoga Webster , Molete Sebolelo Francina
Published: February 2023

The Sosa wetland is a sensitive wetland, situated at the headwaters of the Jordan catchment in Maseru. Due to unregulated land use activities in the past decades (2010–2020), the Sosa wetland nearly dried up. Therefore, this study performed a wetland water balance of the Sosa wetland in Lesotho for the period of 1975–2020 using GIS and remote sensing. Landsat imageries of 1975–2020 were used for land use and land cover while the Penman -Monteith and Thornthwaite methods were used to estimate evapotranspiration. Results show that water/marsh, cultivation, settlements and bare-land increased by 2.04, 4.1, 5.82 and 28.71%, respectively, from 1975 to 2020. Forest and shrubs as well as grasslands decreased by 38.83 and 1.76%, respectively, from 1975 to 2020. Evapotranspiration estimates for the period 1984–2020 were in the range of 900 −1,071 mm/year which is substantially greater than the annual mean rainfall of the catchment which ranges from 550 to 850 mm/year. The most sensitive wetlands are found in the middle reach of the catchment and at the headwaters occupying about 16.03% of the catchment, whereas moderately sensitive wetlands occupy 39.75%. The water balance closure as a ratio of rainfall received ranged from −3.13 to −3.5.
Indian support for Bangladesh during the war of 1971
Authors: Mondal Papiya
Published: February 2023

The article deals with the history and consequences of the 1971 independence war between Bangladesh and Pakistan. The author defines the stages, results of the war, provides statistical data.
Production Technology and Functionality of Bioactive Peptides
Authors: Wen Qingmei , Zhang Lei , Zhao Feng , Chen Yilu , Su Yi , Zhang Xiaochun , Chen Pu , Zheng Tao
Published: February 2023

Bioactive peptides are specific protein fragments that prove health-promoting potential for humans.
The bioactivities include antimicrobial, antioxidant, anticancer, immunomodulatory activities, etc. Hence, bioactive
peptides’ production technology and processes have attracted excessive attention, especially concerning
peptides’ synthesis, separation, identification, and functionality. This review summarizes the relevant investigations
from the above four aspects. Among the production technology of bioactive peptides, biosynthesis, chemosynthesis,
technology for separation and purification, and the interactions responsible for peptide-based
nanostructures are emphasized. Here, the biosynthesis of peptides includes enzymatic hydrolysis, microbial fermentation,
and recombinant DNA technology, and chemosynthesis consists of solution-phase peptide synthesis
and solid-phase peptide synthesis (SPPS). The commonly used enzymes in enzymatic hydrolysis are investigated,
including pepsin, trypsin, and alcalase. The commonly used microorganisms, typical processes, protein
sources, and advantages of microbial fermentation are analyzed. Membrane separation (including ultrafiltration
and nanofiltration), chromatography technology (including ion-exchange chromatography, gel filtration chromatography,
affinity chromatography, and reverse-phase high-performance liquid chromatography (RP-HPLC)),
and electrophoresis technology are detailed for the purification technology. Mass spectrometry (MS), its combination
with the high-performance separation method, and nuclear magnetic resonance (NMR) are elucidated for
the identification technology. The non-covalent interactions responsible for peptide-based nanostructures involve
electrostatic force, hydrogen bonds, π-π stacking, hydrophobic interaction, and van der Waals force. Afterward,
we detail the peptides’ antihypertensive, antithrombotic, anticancer, antimicrobial, antioxidant, and immunomodulatory
activities. The activity analysis mainly involves peptides’ sources, structural features, mechanisms
of action, and influencing factors. Based on the production and functionality elucidation, potential challenges
for peptide application in biomedicine are given. The challenge is analyzed from the aspects of purification
and identification technologies and influencing factors of peptides’ bioactivities. Our work will elaborate
on advances in the production technology of peptides and their bioactivities, which could promote and expand
their industrial applications.
Cystic Fibrosis Transmembrane Conductance Regulator Protein Modulators
in Children and Adolescents with Different CF Genotypes - Systematic
Review and Meta-Analysis
Authors: Yousif Hamdan Alaa Hassan , Zakaria Faiza , Lourdes Pormento Maria Kezia , Lawal Odunayo Susan , Opiegbe Adaugo , Zahid Samina , Guntipalli Prathima , Nasr Ujala , Hasan Rizvi Syed Asad
Published: February 2023

Objective:

To determine the efficacy of the first triple CFTR protein modulators in children
and adolescents with cystic fibrosis.

Methods:

Systematic review and meta-analysis were conducted, following PRISMA guidelines. The
following databases were searched extensively: PubMed/Medline, Clinical trials.gov, Google Scholar,
Scopus, Embase, and Europe PMC using the keywords: “Ivacaftor”, “Elexacaftor”, “Tezacaftor”,
VX_661”, VX_770”, “VX_445”, “cystic fibrosis”. A total of ten randomized clinical trials were included
in our analysis. Primary outcomes included: Absolute change in predicted FEV1 from baseline,
Absolute change in sweat chloride test from baseline, Absolute change in BMI from baseline, Absolute
change in CF-QR from baseline, and Adverse Events.

Results:

Among primary findings, significant absolute change in predictive FEV1 from baseline
through 4 weeks favoured the triple CFTR protein modulators. (MD = 11.80, 95% CI = 8.47_15.12, p
value = <0.00001); as well as CF_QR score (MD = 0.00, 95% CI = -2.50_2.50, p value = 1.00), and
BMI kg/m² change (MD = 16.90, 95% CI = 12.73_21.06, p value = <0.00001). No significant change
was noted for CFTR channels activity in the treatment group when compared to placebo or
VX_770/VX_661 (MD = -12.57, 95% CI = -94.46_69.32, p value = 0.76).

Conclusion:

In children aged ≥ 6 y old and adolescents with F508del_CFTR mutation, Elexacaftor-
Tezacaftor-Ivacaftor tend to be more effective than first-generation therapy, demonstrating promising
results by exhibiting significant improvement in lung function, body weight, and respiratory-related
quality of life.
TOTAL BAL, VISKOSITAS, PH DAN PADATAN TERLARUT KEFIR SUSU KERBAU DENGAN PEMBERIAN BUAH NAGA MERAH (Hylocereus polyrhizus)
Authors:   Universitas Diponegoro, Tarihoran Winda Chelsy , Hintono Antonius ,   Universitas Diponegoro, Rizqiati Heni ,   Universitas Diponegoro
Published: February 2023

Kefir susu kerbau merupakan pangan fungsional dari olahan susu kerbau yang melalui proses fermentasi dengan penambahan kefir grain yang memiliki kemampuan probiotik. Buah naga merah merupakan buah berwarna menarik serta mempunyai efek baik bagi kesehatan karena mengandung bioaktif yaitu antioksidan. Penelitian bertujuan untuk memahami pengaruh pemberian berbagai konsentrasi buah naga merah terhadap total BAL, viskositas, pH, dan total padatan terlarut kefir susu kerbau. Perlakuan pemberian buah naga merah yaitu 0%, 5%, 10%, 15% dan 20% (v/v). Parameter uji meliputi total BAL, viskositas, pH, dan total padatan terlarut. Percobaan dilakukan dengan 5 perlakuan dan 4 ulangan menggunakan RAL. Hasil pengujian dianalisis dengan uji Anova dengan taraf signifikansi 95% dan dilanjut dengan Duncan Test. Hasil penelitian menunjukkan, semakin tinggi penambahan buah naga merah maka total BAL, viskositas dan total padatan terlarut semakin tinggi, namun pH kefir susu kerbau mengalami penurunan.
KARAKTERISTIK SENSORIS WINE COFFEE DAN NATURAL COFFEE ARABIKA AMPELGADING
Authors:   Agricultural Product Technology Department, Agricultural Technology Faculty, Brawijaya University, Maligan Jaya Mahar , Ramadhan Reza Luckyvianto ,   Departemen Ilmu Pangan dan Bioteknologi FTP Universitas Brawijaya, Prihatiningtyas Regita ,   Universitas Brawijaya
Published: February 2023

Data BPS menunjukkan, kopi yang diproduksi untuk petani rakyat Indonesia akan meningkat dari tahun 2016 hingga 2018, dengan rata-rata produksi sebesar 667,3 ton. Jenis kopi yang populer adalah robusta (Coffea canephora) dan arabika (Coffea arabica L.). Produksi tertinggi mencapai 81% dari total produksi kopi Indonesia disumbang oleh kopi robusta, selebihnya yaitu kopi arabika. Wine Coffee yaitu kopi pilihan yang telah dipetik tanpa mengupas kulitnya kemudian difermentasi dalam waktu lama, dan minuman tersebut memperoleh aroma dan rasa yang mengingatkan pada wine. Penelitian ini dilakukan untuk mengidentifikasi karakteristik sensoris (cita rasa) pada berbagai metode pasca panen yaitu natural dan wine kopi. Seluruh penilaian karakteristik seduhan kopi berdasarkan cita rasa nya dikerjakan panelis terlatih. Karakteristik cita rasa wine coffee berdasakan hasil penilaian memiliki total skor dan penilaian semua karakteristik cupping yang lebih tinggi dibanding kopi proses natural.
KARAKTERISTIK KIMIA FLAKES DENGAN PROPORSI TEPUNG JAGUNG DAN TEPUNG KACANG TUNGGAK YANG DIPERKAYA DENGAN MINYAK BIJI BUNGA MATAHARI
Authors:   Universitas Pembangunan Nasional Veteran Jawa Timur, Firdausy Nurul , Rosida Dedin Finatsiyatull ,   Universitas Pembangunan Nasional Veteran Jawa Timur, Winarti Sri ,   Universitas Pembangunan Nasional Veteran Jawa Timur
Published: February 2023

Flakes merupakan jenis makanan sereal yang dapat dikembangkan dalam meningkatkan nilai gizi seperti protein dan lemak. Flakes jagung yang kaya akan kandungan pati dapat dipadukan dengan tepung kacang tunggak yang kaya akan kandungan protein, dan minyak biji bunga matahari mengandung banyak asam lemak esensial. Penelitian ini memiliki tujuan untuk memahami karakteristik kimia flakes dengan perbandingan tepung jagung dan tepung kacang tunggak serta diperkaya dengan minyak biji bunga matahari. Metode RAL digunakan dengan faktor pertama perbandingan tepung jagung dengan tepung kacang tunggak (50:50, 60:40, dan 70:30), dan faktor kedua yaitu konsentrasi pertambahan minyak biji bunga matahari (4%, 6%, dan 8% (v/b)). Hasil penelitian menunjukkan nilai karakteristik kimia produk flakes meliputi kadar air 2.47-2.96 %, kadar abu 1.45-1.76 %, kadar lemak 3.76-7.46 %, kadar protein 6.8-7.24 % dan kadar karbohidrat 81.36-84.85 %. Sifat kimia produk flakes dapat dipengaruhi oleh formulasi tepung jagung, tepung kacang tunggak dan konsentrasi minyak biji bunga matahari.
A HEDONIC ANALYSIS OF TENGGER TYPICAL CHILI SAUCE (CASE STUDY IN NGADIWONO VILLAGE, TOSARI DISTRICT, PASURUAN REGENCY)
Authors:   Universitas Brawijaya, Septiana Siska , Ali Dego Yusa ,   Universitas Brawijaya, Estiasih Teti ,   Universitas Brawijaya, Rayesa Neza Fadia ,   Universitas Brawijaya, Fibrianingtyas Alia ,   Universitas Brawijaya, Latansya Nevara ,   Universitas Brawijaya, Bimo Igoy Arya ,   Universitas Brawijaya
Published: February 2023

Habanero-type pepper (Capsicum chinense) is one of the main horticultural commodities in the Tengger mountains. These chilies is potential to be processed into ready-to-eat products. The development of this product is expected to improve the Tengger local economy. This study aims to determine the level of acceptance of Tengger typical chili sauce made from habanero-type pepper with and without the shrimp paste. A 5-point scale hedonic test was conducted to analyze the liking score of the original Tengger chili sauce, chili sauce with shrimp paste and commercial chili sauce as reference. 30 untrained panelists participated in this test. There was a significant difference in the liking scores especially on color attribute (p<0.05). Panelists gave lower acceptance scores to chili sauce with shrimp paste in color, aroma, and taste attributes. In general, the original Tengger chili sauce without the addition of shrimp paste is competitive with commercial chili sauce.
Cost-Effectiveness Analysis Penggunaan Antidiabetik Oral pada Pasien Diabetes Melitus Rawat Jalan di RSU Haji Surabaya
Authors:   Faculty of Pharmacy Airlangga University Surabaya, Faza Rahmadanita Fathia , Maulina Novia ,   Faculty of Pharmacy Airlangga University Surabaya, Sugihantoro Hajar ,   Faculty of Pharmacy Airlangga University Surabaya, Muhimmah Ilmiyatul ,   Faculty of Pharmacy Airlangga University Surabaya, F. Saputra Azian ,   Faculty of Pharmacy Airlangga University Surabaya
Published: February 2023

Pendahuluan: Diabetes melitus adalah penyakit kronis akibat proses metabolisme dalam tubuh yang tidak normal yang ditandai dengan adanya peningkatan kadar glukosa darah melebihi batas normal dalam tubuh. Diabetes melitus membutuhkan perawatan medis secara terus-menerus sehingga biaya medis yang dikeluarkan besar. Tujuan: Untuk mengetahui dan menganalisis efektivitas biaya penggunaan antidiabetik oral pada pasien diabetes melitus tipe 2 rawat jalan di RSU Haji Surabaya. Metode: Penelitian ini adalah penelitian deskriptif observasional dengan data retrospektif berupa rekam medis dan biaya pengobatan pasien rawat jalan dengan penyakit diabetes melitus tipe 2 di RSU Haji Kota Surabaya Periode Juni-November 2021. Analisis data dilakukan menggunakan rumus Average Cost-Effectiveness Ratio (ACER) dan Incremental Cost-Effectiveness Ratio (ICER). Hasil: Didapatkan 70 pasien diabetes melitus tipe 2 dengan penyakit penyerta yang memenuhi kriteria inklusi. Penggunaan terapi antidiabetik oral monoterapi ditemukan pada 11 pasien dan pada terapi antidiabetik oral kombinasi sebanyak 59 pasien. Antidiabetik oral monoterapi yang paling banyak digunakan adalah glimepiride (8,57%), sedangkan pada antidiabetik oral kombinasi adalah kombinasi metformin dan glimepiride (17,14%). Terapi antidiabetik oral monoterapi yang paling cost-effective adalah gliklazid dengan nilai efektivitas sebesar 100%, nilai ACER sebesar Rp 1.331,15. dan nilai ICER Rp. -641,70 dan Rp. -714.52. Sedangkan terapi antidiabetik oral kombinasi yang paling cost-effective adalah kombinasi pioglitazone, metformin dan glimepiride dengan nilai efektivitas 55,56%, nilai ACER sebesar Rp 3.266,34 dan nilai ICER Rp. 1.491,54 dan Rp. 1.654,43. Kesimpulan: Berdasarkan parameter ACER dan ICER, antidiabetik oral monoterapi yang paling cost-effective adalah gliklazid. Sedangkan antidiabetik oral kombinasi yang paling cost-effective adalah kombinasi pioglitazone, metformin dan glimepiride.
The Quantitative and Qualitative Analysis of Antibiotic Use in Bone Fracture Patients in a Public Hospital in Indonesia
Authors:   Master of Clinical Pharmacy Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia, Atmajani Wanudya , Hasmono Didik ,   Department Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia, Maryati Awdisma Wien ,   Master of Clinical Pharmacy Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia, Isparnadi Erwien ,   Haji General Hospital, Surabaya, Indonesia, Ramdani Dewi ,   Haji General Hospital, Surabaya, Indonesia
Published: February 2023

Introduction: Prophylactic antibiotic therapy has an important role in facilitating optimal postoperative healing. Inappropriate use of antibiotics in hospitals will increase the cost of therapy and the incidence of nosocomial infections of infectious microorganisms. Preoperative prophylactic antibiotics are believed to reduce the incidence of surgical site infections. Objective: This study aims to determine the pattern of antibiotic use and analyse the use of antibiotics qualitatively by the Gyssen method and quantitatively by the defined daily dose (DDD) method in inpatients with bone fractures at the Haji General Hospital Surabaya, Indonesia. Methods: This study was a descriptive observational study conducted on 89 samples. Data were collected retrospectively through medical records in the period January-December 2019. Antibiotic use data were then analysed qualitatively and quantitatively using the Gyssen and DDD methods. Results: In this study, the antibiotic that was widely used as a prophylactic and therapeutic antibiotic in patients with bone fractures was ceftriaxone. Quantitative analysis using the DDD method showed that the value of ceftriaxone was 45.6/100 patient-days and cefazoline was 3.1/100 patient-days. Analysis of antibiotic use in bone fracture patients using the Gyssen method showed that the rational use of antibiotics was 84.3%, the use of antibiotics was not timely as much as 4.5%, and the interval of antibiotic administration was not appropriate as much as 11.2%. Conclusion: the use of antibiotics in fracture surgery patients is classified as rational use of antibiotics but the use of antibiotics still exceeds WHO standards. Furthermore, it is necessary to conduct a similar study with prospective data collection so that it can observe the incidence of surgical wound infection.