bluuebunny/crossref_metadata_2025 huggingface dataset:
Geographic, Demographic, and Socioeconomic Disparities and Factors Associated With Cancer Literacy in China: National Cross-sectional Study
Authors: He Siyi , Li He , Cao Maomao , Sun Dianqin , Yang Fan , Yan Xinxin , Zhang Shaoli , Xia Changfa , Yu Yiwen , Zhao Liang , Shi Jufang , Li Ni , Yu Xue Qin , Chen Wanqing , He Jie
Published: February 2023

Background

Cancer literacy is associated with several health-related behaviors and outcomes. However, there is still a lack of nationwide surveys for cancer literacy in China.

Objective

This study aims to evaluate cancer literacy in China, explore disparities, and provide scientific evidence for policy makers.

Methods

A cross-sectional survey was conducted in mainland China in 2021 using the multistage probability proportional to the size sampling method. Both the reliability and validity of the questionnaire were evaluated. The awareness levels were adjusted by sampling weights and nonrepresentativeness weights to match the actual population distributions. The Rao-Scott adjusted chi-square test was applied to test geographic, demographic, and socioeconomic disparities. A generalized linear model was used to explore potential factors.

Results

A total of 80,281 participants aged 15-74 years were finally enrolled from 21 provinces, with an overall response rate of 89.32%. The national rate of cancer literacy was 70.05% (95% CI 69.52%-70.58%). The rates were highest regarding knowledge of cancer management (74.96%, 95% CI 74.36%-75.56%) but were lowest regarding basic knowledge of cancer (66.77%, 95% CI 66.22%-67.33%). Cancer literacy was highest in East China (72.65%, 95% CI 71.82%-73.49%), Central China (71.73%, 95% CI 70.65%-72.81%), and North China (70.73%, 95% CI 68.68%-72.78%), followed by Northeast (65.38%, 95% CI 64.54%-66.22%) and South China (63.21%, 95% CI 61.84%-64.58%), whereas Southwest (59.00%, 95% CI 58.11%-59.89%) and Northwest China (57.09%, 95% CI 55.79%-58.38%) showed a need for improvement. Demographic and socioeconomic disparities were also observed. Urban dwellers, the Han ethnic group, and population with higher education level or household income were associated with prior knowledge. The questionnaire showed generally good internal and external reliability and validity.

Conclusions

It remains important for China to regularly monitor levels of cancer literacy, narrow disparities, and strengthen health education for dimensions with poor performance and for individuals with limited knowledge to move closer to the goal of Healthy China 2030.
Evaluation of a Mobile-Based Immunization Decision Support System for Scheduling Age-Appropriate Vaccine Schedules for Children Younger Than 2 Years in Pakistan and Bangladesh: Lessons From a Multisite, Mixed Methods Study (Preprint)
Authors: Siddiqi Danya Arif , Ali Rozina Feroz , Shah Mubarak Taighoon , Dharma Vijay Kumar , Khan Anokhi Ali , Roy Tapash , Chandir Subhash
Published: February 2023

BACKGROUND

Missed opportunities for vaccination (MOVs), that is, when children interact with the health system but fail to receive age-eligible vaccines, pose a crucial challenge for equitable and universal immunization coverage. Inaccurate interpretations of complex catch-up schedules by health workers contribute to MOVs.

OBJECTIVE

We assessed the feasibility of a mobile-based immunization decision support system (iDSS) to automatically construct age-appropriate vaccination schedules for children and to prevent MOVs.

METHODS

A sequential exploratory mixed methods study was conducted at 6 immunization centers in Pakistan and Bangladesh. An android-based iDSS that is packaged in the form of an application programming interface constructed age-appropriate immunization schedules for eligible children. The diagnostic accuracy of the iDSS was measured by comparing the schedules constructed by the iDSS with the gold standard of evaluation (World Health Organization–recommended Expanded Programme on Immunization schedule constructed by a vaccines expert). Preliminary estimates were collected on the number of MOVs among visiting children (caused by inaccurate vaccination scheduling by vaccinators) that could be reduced through iDSS by comparing the manual schedules constructed by vaccinators with the gold standard. Finally, the vaccinators’ understanding, perceived usability, and acceptability of the iDSS were determined through interviews with key informants.

RESULTS

From July 5, 2019, to April 11, 2020, a total of 6241 immunization visits were recorded from 4613 eligible children. Data were collected for 17,961 immunization doses for all antigens. The iDSS correctly scheduled 99.8% (17,932/17,961) of all age-appropriate immunization doses compared with the gold standard. In comparison, vaccinators correctly scheduled 96.8% (17,378/17,961) of all immunization doses. A total of 3.2% (583/17,961) of all due doses (across antigens) were missed in age-eligible children by the vaccinators across both countries. Vaccinators reported positively on the usefulness of iDSS, as well as the understanding and benefits of the technology.

CONCLUSIONS

This study demonstrated the feasibility of a mobile-based iDSS to accurately construct age-appropriate vaccination schedules for children aged 0 to 23 months across multicountry and low- and middle-income country settings, and underscores its potential to increase immunization coverage and timeliness by eliminating MOVs.
Willingness to Use Mobile Health Devices in the Post–COVID-19 Era: Nationwide Cross-sectional Study in China (Preprint)
Authors: Wang Xue , Wu Yibo , Meng Zhiyu , Li Jiayuan , Xu Li , Sun Xinying , Zang Shuang
Published: February 2023

BACKGROUND

Despite the increased development and use of mobile health (mHealth) devices during the COVID-19 pandemic, there is little knowledge of willingness of the Chinese people to use mHealth devices and the key factors associated with their use in the post–COVID-19 era. Therefore, a more comprehensive and multiangle investigation is required.

OBJECTIVE

We aimed to probe Chinese attitudes regarding the use of mHealth and analyze possible associations between the attitude of willingness to use mHealth devices and some factors based on the socioecological model.

METHODS

A survey was conducted using quota sampling to recruit participants from 148 cities in China between June 20 and August 31, 2022. Data from the survey were analyzed using multiple stepwise regression to examine the factors associated with willingness to use mHealth devices. Standardized regression coefficients (β) and 95% CIs were calculated using multiple stepwise regression.

RESULTS

The survey contained a collection of 21,916 questionnaires and 21,897 were valid questionnaires, with a 99.91% effective response rate. The median score of willingness to use mHealth in the post–COVID-19 era was 70 points on a scale from 0 to 100. Multiple stepwise regression results showed that the female gender (β=.03, 95% CI 1.04-2.35), openness personality trait (β=.05, 95% CI 0.53-0.96), higher household per capita monthly income (β=.03, 95% CI 0.77-2.24), and commercial and multiple insurance (β=.04, 95% CI 1.77-3.47) were factors associated with the willingness to use mHealth devices. In addition, people with high scores of health literacy (β=.13, 95% CI 0.53-0.68), self-reported health rating (β=.22, 95% CI 0.24-0.27), social support (β=.08, 95% CI 0.40-0.61), family health (β=.03, 95% CI 0.03-0.16), neighbor relations (β=.12, 95% CI 2.09-2.63), and family social status (β=.07, 95% CI 1.19-1.69) were more likely to use mHealth devices.

CONCLUSIONS

On the basis of the theoretical framework of socioecological model, this study identified factors specifically associated with willingness of the Chinese people to use mHealth devices in the post–COVID-19 era. These findings provide reference information for the research, development, promotion, and application of future mHealth devices.
Efficacy of a Text-Based Mental Health Coaching App in Improving the Symptoms of Stress, Anxiety, and Depression: Randomized Controlled Trial (Preprint)
Authors: Lim Yee Siew , Quek Jia Hui , Ching Xiu Wei , Lim Dominic Tao Ran , Lim Kean Ghee , Thuraisingham Chandramani , George Parikial Philip
Published: February 2023

BACKGROUND

Stress, anxiety, and depression are major mental health concerns worldwide. A wide variety of digital mental health interventions have demonstrated efficacy in improving one’s mental health status, and digital interventions that involve some form of human involvement have been shown to demonstrate greater efficacy than self-guided digital interventions. Studies demonstrating the efficacy of digital mental health interventions within the Asian region are scarce.

OBJECTIVE

This study aimed to investigate the potential efficacy of the digital mental health intervention, ThoughtFullChat, which consists of one-on-one, asynchronous, text-based coaching with certified mental health professionals and self-guided tools, in improving self-reported symptoms of depression, anxiety, and stress. The study also aims to examine the potential differences in efficacy among occupational subgroups and between sexes.

METHODS

A randomized controlled study was conducted among housemen (trainee physicians), students, faculty members, and corporate staff at International Medical University, Malaysia. A total of 392 participants were enrolled and randomized to the intervention (n=197, 50.3%) and control (n=195, 49.7%) groups. Depression, anxiety, and stress symptoms were measured using the Depression, Anxiety, and Stress Scale–21 items at baseline and after the 3-month intervention period. The Satisfaction with Life Scale and Brief Resilience Scale were also included, along with a questionnaire about demographics.

RESULTS

Significant decrease was observed in depression (P=.02) and anxiety (P=.002) scores in the intervention group. A subgroup (corporate staff) also demonstrated significant decrease in stress (P=.005) alongside depression (P=.006) and anxiety (P=.002). Females showed significant improvements in depression (P=.02) and anxiety (P<.001) when compared with males.

CONCLUSIONS

This study provides evidence that the ThoughtFullChat app is effective in improving the symptoms of depression, anxiety, and stress in individuals, particularly among corporate staff from the educational field. It also supports the notion that mobile mental health apps that connect users to mental health professionals in a discreet and cost-efficient manner can make important contributions to the improvement of mental health outcomes. The differential improvements among occupational subgroups and between sexes in this study indicate the need for future digital mental health app designs to consider an element of personalization focused on systemic components relating to occupation.

CLINICALTRIAL

Clinicaltrials.gov NCT04944277; https://classic.clinicaltrials.gov/ct2/show/NCT04944277
Exploring the Incorporation of a Novel Cardiotoxicity Mobile Health App Into Care of Patients With Cancer: Qualitative Study of Patient and Provider Perspectives (Preprint)
Authors: Gregory Megan E , Cao Weidan , Rahurkar Saurabh , Jonnalagadda Pallavi , Stock James C , Ghazi Sanam M , Reid Endia , Berk Abigail L , Hebert Courtney , Li Lang , Addison Daniel
Published: February 2023

BACKGROUND

Cardiotoxicity is a limitation of several cancer therapies and early recognition improves outcomes. Symptom-tracking mobile health (mHealth) apps are feasible and beneficial, but key elements for mHealth symptom-tracking to indicate early signs of cardiotoxicity are unknown.

OBJECTIVE

We explored considerations for the design of, and implementation into a large academic medical center, an mHealth symptom-tracking tool for early recognition of cardiotoxicity in patients with cancer after cancer therapy initiation.

METHODS

We conducted semistructured interviews of >50% of the providers (oncologists, cardio-oncologists, and radiation oncologists) who manage cancer treatment-related cardiotoxicity in the participating institution (n=11), and either interviews or co-design or both with 6 patients. Data were coded and analyzed using thematic analysis.

RESULTS

Providers indicated that there was no existing process to enable early recognition of cardiotoxicity and felt the app could reduce delays in diagnosis and lead to better patient outcomes. Signs and symptoms providers recommended for tracking included chest pain or tightness, shortness of breath, heart racing or palpitations, syncope, lightheadedness, edema, and excessive fatigue. Implementation barriers included determining who would receive symptom reports, ensuring all members of the patient’s care team (eg, oncologist, cardiologist, and primary care) were informed of the symptom reports and could collaborate on care plans, and how to best integrate the app data into the electronic health record. Patients (n=6, 100%) agreed that the app would be useful for enhanced symptom capture and education and indicated willingness to use it.

CONCLUSIONS

Providers and patients agree that a patient-facing, cancer treatment-related cardiotoxicity symptom-tracking mHealth app would be beneficial. Additional studies evaluating the role of mHealth as a potential strategy for targeted early cardioprotective therapy initiation are needed.
English Pronunciation Learning Challenges: A Case study of Mundu EFL learners in Chad
Authors: Nkongho Magdaline Bakume , Mbaiornom Ernest
Published: February 2023

The present study aims at investigating the pronunciation components in the prescribed English Language Syllabus for High Schools as well as the pronunciation instruction in some selected High Schools in Moundou, Chad, in order to determine the impact on learners’ production with respect to this phonological feature. The content analysis method was adopted for the investigation. Data were drawn from consultation of the National English Language Syllabus for High Schools in Chad, and 44 English Teachers’ logbooks for the 2021/2022 academic year. These logbooks were collected from 6 Government High Schools in Moundou. Two research questions guided the collection of data which were later on classified, put in numerical data and analysed within the framework of the Factors Affecting Pronunciation Theory. Results of the study revealed a total lack of pronunciation prescription in the English language syllabus and a zero percent representation of pronunciation related lessons in English language classes. Hence, it could be concluded that pronunciation instruction in English language lessons, to a greater extent, has been neglected in some High Schools in Chad. This has created enormous challenges resulting to poor pronunciation, segmental feature errors, and deviances in supra-segments, etc., in the speech production of learners.
Entrepreneurial Education and Entrepreneurship: The Mediating Role of Social Skills in University Students
Authors: Irikefe Pureheart Ogheneogaga
Published: February 2023

The study sought to investigate the various mediating impacts of social skills in the form of political acumen and entrepreneurial opportunity recognition on perceived entrepreneurial education and entrepreneurship of university students. This was accomplished through the use of a survey research design. The study used primary qualitative data that was converted into quantitative data using 5-point Likert scaling. The questionnaire used for the study was tested for its reliability and validity using confirmatory factor analysis and was found to be adequate for the study. Data was gotten from 269 Bingham University student entrepreneurs in Nigeria and was analysed using structural equation modelling. The findings revealed that there is a positive significant relationship between perceptions of entrepreneurial education and entrepreneurship; political acumen and entrepreneurial opportunity recognition each play a mediating role between perceived entrepreneurial education and entrepreneurship; and social skills work together to mediate perceived entrepreneurial education and entrepreneurship. The study, therefore, recommends that student entrepreneurs should construct a learning network through their engagement in the classroom and develop professional entrepreneurial and social skills.
Productivity of Machine Translation
Authors: Qizi Yunusova Nilufar Maxmudjon
Published: February 2023

This article is about the field of technical translation which is called machine translation (MT), or machine-assisted translation. This method of translation uses various types of computer software to generate translations from a source language to a target language without the assistance of a human. There are different methods of machine translation. A plethora of machine translators in the form of free search engines are available online. However, within the field of technical communication, there are two basic types of machine translators, which are able to translate massive amounts of text at a time. There are transfer-based and data-driven machine translators. Transfer-based machine translation systems, which are quite costly to develop, are built by linguists who determine the grammar rules for the source and target languages. The machine works within the rules and guidelines developed by the linguist. Due to the nature of developing rules for the system, this can be very time-consuming and requires an extensive knowledge base about the structures of the languages on the part of the linguist; nonetheless, the majority of commercial machine translators are transfer-based machines. .
Stylistic Analysis on Selected Literary works of Alicia Tan-Gonzales
Authors: Tribunal-Nemenzo Ruth
Published: February 2023

This study looked into the stylistic analysis of the selected literary works of Alicia Tan-Gonzales. Specifically, this study analyzed three of her Hiligaynon literary works using frameworks for stylistic analysis. Using descriptive research design, this study examined phonetic structures and figures of replacement in the poem, Sentensya (Sentence); semantic structures and stylistic deviations in the short story, Mga Luha Para Kay Tatay Jose (Tears for Papa Jose); and turn-taking patterns and topic control that determined power and politeness strategies in the play, Pinustahan Nga Gugma (Betting Love). The stylistic analysis of the poem reveals that (1) for phonetic structures, the rhythmical description and effect of the syllables depended on the divisions of the word structure and grammatical structure; (2) for metrical structures in the poem, unstressed syllables were predominantly used rather than stressed syllables; and (3) for figures of replacement, the significant use of metonymy gave the poem an exaggerated impact. The stylistic analysis of the short story shows that (1) semantic structures based on emotive meaning disclosed the inner mind of the characters; (2) expressive meanings exposed the negative emotional state of the characters; (3) evaluative meanings depicted the characteristics and choices of a strong family woman in society; and (4) as to the reduction on sentence constructions, nominative sentences and ellipsis were evident in the short story, while simple repetition was present, indicating redundancy of sentence construction. The stylistic analysis of the play indicates that (1) the characterizations of different strong women made intuitive descriptions of power based on turn-taking patterns and topic control, although they may not be true in all circumstances in the conversations; and (2) politeness strategies were evident in the play, with positive politeness strategies as the most frequently used, followed by bald on-record, negative politeness, and off-record. Based on the overall results of the study, an instructional module in teaching Stylistics was designed to help students understand the literary style of Alicia Tan-Gonzales in fashioning her selected literary pieces, as well as styles of other literary writers.
Três frentes da política externa do governo Lula para a América Central e o Caribe
Authors: Maia Eduardo
Published: February 2023

Este artigo se insere em uma lacuna dentro de um objeto bastante discutido, além de oferecer uma perspectiva que pode auxiliar a compreensão da política externa brasileira e fundamentar futuras pesquisas. O objetivo é analisar a política externa do governo Lula para a região da América Central e do Caribe. Propõe-se que a atuação brasileira se deu em três frentes: social-humanitária, econômica e político-estratégica. O trabalho foi desenvolvido a partir do conteúdo das Resenhas de Política Exterior do Brasil e de pesquisa da bibliografia brasileira existente sobre a política externa do período. Conclui-se que a região ganhou importância, sem, no entanto, alterar sua condição como eixo secundário da política externa, permanecendo em posição subordinada a outras regiões e objetivos.
Clivaje derechas/izquierdas en los sistemas políticos centroamericanos de posguerra
Authors: Miranda Delgado Rafael Gustavo
Published: February 2023

El objetivo de la investigación es analizar la formación y contemporaneidad del clivaje derechas/izquierdas en los sistemas políticos centroamericanos de posguerra. La metodología a utilizar es el Análisis Histórico Comparado (ahc), La hipótesis guía del estudio es que el clivaje derechas/izquierdas, su constitución y su expresión contemporánea, es fundamental para entender la pluralidad política y la calidad democrática en general en los sistemas políticos centroamericanos de posguerra. En el artículo se afirma que en El Salvador, Guatemala y Nicaragua el clivaje derecha/izquierda ha tenido dificultades para expresarse de forma democrática. En una primera instancia se expresó en la guerra, para luego tener un balance divergente de éxitos y fracasos en la democratización de los actores.
SERIE CARTOGRÁFICA MONARCA Vol. II. Mapa de vegetación y cubiertas del suelo, 2018
Authors:   Centro de Investigaciones en Geografía Ambiental, Ramírez Isabel , López Sánchez Jairo ,   Centro de Investigaciones en Geografía Ambiental, Barrasa García Sara ,   Centro de Investigaciones en Geografía Ambiental
Published: February 2023

Aquí presentamos el mapa de vegetación y cubiertas del suelo de la Reserva de la Biosfera Mariposa Monarca (RBMM) presentes en 2018. Es la segunda parte de la Serie Cartográfica Monarca, cuyo Volumen 1 se publicó hace una década, y ambos son resultado de un proyecto de monitoreo de largo plazo. El monitoreo permite identificar la magnitud y localización de los procesos de cambio en el territorio. Este mapa de vegetación y cubiertas del suelo se generó mediante la interpretación visual de imágenes de satélite Landsat 8, tomadas en febrero de 2018. Las categorías del mapa se validaron con puntos de verificación en campo y en imágenes de satélite de muy alta resolución de 2018 disponibles en la plataforma Google Earth. Se espera que el presente volumen de esta serie cartográfica ayude como un elemento más para el análisis y evaluación crítica de las acciones de manejo y conservación que se llevan a cabo en la RBMM y su zona de influencia.
Los conflictos ambientales en América Latina III: Reflexiones y casos de estudio
Authors: Martín Suárez Francisco ,   Universidad Nacional de General Sarmiento
Published: February 2023

El libro reúne una serie de trabajos que surgen de las actividades que se desarrollan en el marco de la Red Latinoamericana para el Estudio de Conflictos Ambientales (Red CoLCA). Los diferentes capítulos fueron desarrollados en un intercambio entre los autores y autoras y los editores para dar cuenta de la diversidad de conflictos que acontecen en Latinoamérica, tomando estudios de caso de Argentina, Brasil, Colombia y México. A través de ellos se reflexiona en profundidad respecto a las causas que los originan, su complejidad en términos de actores e intereses involucrados y su correlato en impactos sociales, culturales, económicos, políticos y ecológicos. Fiel al espíritu que se persigue en la Red CoLCA, en sus trabajos los autores y las autoras analizan y ponen en discusión la puja de racionalidades y de sentido que involucran los conflictos, su productividad social, institucional y política y las desigualdades que se dan a la hora de tener que afrontar los impactos tanto positivos como negativos de las actividades que los originan.
La capacidad del simulacro en la construcción de vida democrática mediante el diálogo y la observancia de principios cívicos
Authors: Lince Campillo Rosa María , Ayala Blanco Fernando
Published: February 2023

Presentamos a continuación una serie de reflexiones acerca de los principios y dificultades que enfrentamos para establecer un diálogo político en el marco del poder del simulacro. La intención es presentar un panorama para llegar a acuerdos validados no sólo por mayoría, sino consensuados y, en consecuencia, legitimados de forma tal que se puedan llevar a cabo mediante acciones calificadas
Bio-circular-green model in a developing economy
Authors: Chutipat Veraphong , Sonsuphap Rattaphong , Pintong Witaya
Published: February 2023

The Bio-Circular-Green (BCG) economic model, adopted by governments throughout the world, including Thailand, is the prevailing economic development model to manage natural resources more effectively and with little environmental damage (Simachaya, 2021). This research intends to evaluate the administration and management of the BCG model implementation in Thailand, factors influencing the success of implementing the model, and recommendations for enhancing the BCG economy. According to the findings, the BCG Policy Board, the BCG Implementation Committee, and the BCG Implementation Subcommittee supervise the implementation of the BCG model in Thailand. Legalization and regulation, standards and quality assurance, financial aid, tax incentives, a BCG market environment, a strategic management organisation, and budget allocation are key elements influencing the effective implementation of the model. Future action plans proposed by experts include boosting local investments in BCG industries, enhancing financial aid, fostering collaboration amongst diverse sectors, performing systematic research, and integrating current innovation and technology. The paper suggests that laws and regulations should be amended to facilitate BCG businesses to the maximum extent feasible, that standards and quality assurance should be developed for all BCG companies, and that the BCG industry should embrace cutting-edge technology and innovation
Determination of the probiotic properties and optimum growth conditions of Lactiplantibacillus plantarum BG24
Authors: GÖKMEN Gökhan , SARIYILDIZ Seda , CHOLAKOV Remzi , NALBANTSOY Ayşe , BALER Biray , ASLAN Emek , DÜZEL Ahmet , SARGIN Sait , GÖKSUNGUR Yekta , KIŞLA Duygu
Published: February 2023

In this study, the probiotic properties and optimum growth conditions of
Lactiplantibacillus plantarum BG24 were investigated. L. plantarum BG24
have a high probiotic potential due to its growth at low pH and high
bile salt concentrations and its ability to utilize lactose. The
adhesion rate of BG24 to Caco-2 cells was 37.51% and it showed
resistance to 8 of the tested 19 antibiotics. The highest enzymatic
activities of BG24 were found for Leucine arylamidase, β-glucosidase,
Valine arylamidase, β-galactosidase and N-acetyl-β-glucosaminidase. The
specific growth rate, doubling time and biomass productivity values of
L. plantarum BG24 increased by the enrichment of MRS broth (pH 6.5) with
yeast extract (5 g/L). The growth of L. plantarum BG24 was optimized in
stirred tank bioreactor and the maximum biomass production of 3.84 g/L
were obtained at the optimum levels of process variables (aeration rate
0.05 vvm, agitation speed 479 rpm, inoculation rate 3% and time 18 h).
Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study
Authors: Chen Jie , Yuan Shuai , Fu Tian , Ruan Xixian , Qiao Jie , Wang Xiaoyan , Li Xue , Gill Dipender , Burgess Stephen , Giovannucci Edward L. , Larsson Susanna C.
Published: February 2023

OBJECTIVE

We conducted a Mendelian randomization (MR) study to examine the associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs).

RESEARCH DESIGN AND METHODS

Uncorrelated genetic variants associated with type 2 diabetes (n = 231), fasting insulin (n = 38), fasting glucose (n = 71), and hemoglobin A1c (n = 75) at the genome-wide significance were selected as instrument variables. Genetic associations with 23 common GDs were obtained from the FinnGen and UK Biobank studies and other large consortia.

RESULTS

Genetic liability to type 2 diabetes was associated with the risk of 12 GDs. Per 1-unit increase in the log-transformed odds ratio (OR) of type 2 diabetes, the OR was 1.06 (95% CI, 1.03–1.09) for gastroesophageal reflux disease, 1.12 (95% CI, 1.07–1.17) for gastric ulcer, 1.11 (95% CI, 1.03–1.20) for acute gastritis, 1.07 (95% CI, 1.01–1.13) for chronic gastritis, 1.08 (95% CI, 1.03–1.12) for irritable bowel syndrome, 1.04 (95% CI, 1.01–1.07) for diverticular disease, 1.08 (95% CI, 1.02–1.14) for acute pancreatitis, 1.09 (95% CI, 1.05–1.12) for cholelithiasis, 1.09 (95% CI, 1.05–1.13) for cholelithiasis with cholecystitis, 1.29 (95% CI, 1.17–1.43) for nonalcoholic fatty liver disease, 1.12 (95% CI, 1.03–1.21) for liver cirrhosis, and 0.93 (95% CI, 0.89–0.97) for ulcerative colitis. Genetically predicted higher levels of fasting insulin and glucose were associated with six and one GDs, respectively.

CONCLUSIONS

Associations were found between genetic liability to type 2 diabetes and an increased risk of a broad range of GDs, highlighting the importance of GD prevention in patients with type 2 diabetes.
Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study
Authors: Chen Jie , Yuan Shuai , Fu Tian , Ruan Xixian , Qiao Jie , Wang Xiaoyan , Li Xue , Gill Dipender , Burgess Stephen , Giovannucci Edward L. , Larsson Susanna C.
Published: February 2023

  

OBJECTIVE

We conducted a Mendelian randomization (MR) study to examine the associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs). 

RESEARCH DESIGN & METHODS

Uncorrelated genetic variants associated with type 2 diabetes (n=231), fasting insulin (n=38), fasting glucose (n=71), and hemoglobin A1c (n=75) at the genome-wide significance were selected as instrument variables. Genetic associations with 23 common GDs were obtained from the FinnGen and UK Biobank studies, and other large consortia. 

RESULTS

Genetic liability to type 2 diabetes was associated with the risk of 12 GDs. Per one-unit increase in log-transformed odds ratio of type 2 diabetes, the odds ratio was 1.06 (95% confidence interval (CI) 1.03-1.09) for gastroesophageal reflux disease, 1.12 (95% CI 1.07-1.17) for gastric ulcer, 1.11 (95% CI 1.03-1.20) for acute gastritis, 1.07 (95% CI 1.01-1.13) for chronic gastritis, 1.08 (95% CI 1.03-1.12) for irritable bowel syndrome, 1.04 (95% CI 1.01-1.07) for diverticular disease, 1.08 (95% CI 1.02-1.14) for acute pancreatitis, 1.09 (95% CI 1.05-1.12) for cholelithiasis, 1.09 (95% CI 1.05-1.13) for cholelithiasis with cholecystitis, 1.29 (95% CI 1.17-1.43) for non-alcoholic fatty liver disease, 1.12 (95% CI 1.03-1.21) for liver cirrhosis, and 0.93 (95% CI 0.89-0.97) for ulcerative colitis. Genetically predicted higher levels of fasting insulin and glucose were associated with 6 and 1 GDs, respectively.

CONCLUSIONS

This study found associations between genetic liability to type 2 diabetes and an increased risk of a broad range of GDs, highlighting the importance of GD prevention in type 2 diabetes patients. 
The Relationship Between Science Process Skills and Students' Creative Thinking Skills on Magnetism in Junior High School
Authors: Darmaji  , Astalini  , Dwi Agus Kurniawan  , Bob Widodi
Published: February 2023

Physics lessons are classified as difficult subjects, so students need to do practical work to make it easier for them to understand the material concept. This study aims to analyze the relationship between students' science process skills and junior high school students creative thinking skills in magnetism. The method used in this study is mixed. This study used a sample of 40 people from class VIII SMP. The sampling technique is Simple Random Sampling. The research instruments used in this study were observation sheets, questionnaires, and interview sheets. The data analysis technique used is quantitative and qualitative data analysis techniques. Quantitative data analysis was carried out using descriptive statistical tests and inferential statistics. This research results show that the percentage of students' science process skills in class VIII C is 70% in the good category. While in class VIII F 75% are in a Good category. Moreover, the percentage of students' creative thinking skills in class VIII C is 60% in the good category, while in class VIII F is 55.0% in the good category. This study concludes that there is a significant relationship between students' science process skills and students' creative thinking skills in class VIII SMP magnetism material. This research implies that it is helpful for teachers and prospective teachers to improve students' science processes and creative thinking skills. Moreover, this research can be used by teachers as a guide to evaluating students' science process skills and creative thinking abilities.
Museum Virtual Tour Development Using 3D Vista as a History Learning Source
Authors: Syukur Syarifuddin , Dewie Siti Swasti Eka , Oktarina Santi
Published: February 2023

Visits to museums are also a means of learning that arouses curiosity and provides a different nuance in learning. The problem today is that distance and time are not possible if the teacher brings students to the location of the museum. An alternative solution to these problems is to use technology. This study aims to develop a virtual tour learning tool at the Sriwijaya museum by using the 3D Vista application as a source for learning history. The stages of this research adapt to the product development research model of Alessi and Trollip, namely design, planning, and development. The device developed was validated by experts and tested on the subjects 30 student of class X at senior high school. The trial design in this study used a one group pretest and posttest design. Data collection techniques include interviews, tests, and questionnaires. The data analysis technique used analysis of the results of interviews, tests, and questionnaires. The result of this study are, 1) the developed learning tools have been tested for validity after going through validation with 4 experts; 2) virtual tour museum learning resources have been tested for practicality with a practicality percentage of 87.87%; and 3) the effectiveness of the device consisting of student activities in the learning process obtained an N-Gain of 5.57 with a medium category. The conclusion of this study is that the learning tools developed were tested to be valid, practical, and effective.
Video Pembelajaran Menggunakan Model ADDIE pada Tematik Siswa Kelas III Sekolah Dasar
Authors: Tesalonika  , Desak Putu Parmiti  , I Gde Wawan Sudatha
Published: February 2023

Beberapa kegiatan pembelajaran tidak berjalan secara maksimal yang disebabkan karena guru kurang mampu mengembangkan media digital yang membantu meningkatkan motivasi belajar siswa. Tujuan penelitian ini yaitu mengembangkan  video pembelajaran menggunakan model ADDIE pada tematik kelas III SD. Jenis penelitian ini yaitu pengembangan menggunakan model ADDIE. Subjek uji coba yaitu 1 ahli materi pembelajaran, 1 ahli desain pembelajaran, dan 1 ahli media pembelajaran. Subjek uji coba yaitu siswa yang berjumlah 12. Metode pengumpulan data dengan pencatatan dokumen, kuesioner, dan wawancara. Instrument pengumpulan data berupa lembar pencatatan dokumen dan kuesionerTeknik analisis data yang digunakan yaitu analisis deskriptif kualitatif dan analisis deskriptif kuantitatif. Hasil penelitian yaitu penilaian yang diberikan dari ahli materi pembelajaran yaitu 92% (sangat baik), ahli desain pembelajaran yaitu 92,72% (sangat baik), dan ahli media pembelajaran yaitu 90,77 (sangat baik). Hasil uji coba perorangan yaitu 91% (sangat baik) dan kelompok kecil yaitu 93,47% (sangat baik). Disimpulkan bahwa video pembelajaran layak digunakan dalam pembelajaran Tematik.
MDD And Structural Change in Hippocampus and Mpfc
Authors: Yang Jichen
Published: February 2023

MDD (major depressive disorder) is a serious, often chronic, and disabling mental disorder, which affects various brain areas. MDD is characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Stress model including chronic stress and early life stress could be the trigger for MDD and neurotransmitter disorder theory is the mainstream explanation of the disease. MDD would cause disfunction of the brain from different aspects. The MDD mainly affect the brain structure by neurotoxic progress, which includes multiple pathways and neurotransmitter causing the brain structural changes. Hippocampus and mPFC are the most common brain areas could be affected by the MDD, the structural changes could be found by fMRI. The review would focus on introducing mainstream models and how they affect the brain structure. At the end, this review would also involve the regular antidepressants and aspects of future study.
Evaluation of the Finnish action plan for the sustainable use of pesticides 2018–2022
Authors: Autio Sari , Laitala Emilia , Kallio-Mannila Kaija
Published: February 2023

The Finnish National Action Plan (NAP) on the Sustainable Use of Plant Protection Products for 2018–2022 was evaluated by a survey indicated to the experts involved in its implementation in 2022. The survey revealed several successes such as the training and certification system of professional users, retailers and advisers, regular inspection of spray equipment, and the web-based register of plant protection products (PPP). Measures, where further improvement is necessary, are, e.g., setting of environmental quality standards for all active substances, and monitoring of surface and ground waters for PPP residues, which has suffered from a lack of resources during the NAP period. Overall screening of the sustainability goals revealed progress in all aspects, though targeting, resourcing, and monitoring remained the area with least progress compared to the same screening conducted in 2015. The perception of the experts on the constraints that limit the fulfilment of the NAP most seriously remained similar compared to their views in 2014.
And they try, and they praise, but they don’t marry: Once again about the connection between downloads, views and citations
Authors: Khokhlov A. N. , Morgunova G. V.
Published: February 2023

The question of the possible influence of the number of views / downloads of scientific articles from journal websites, as well as the number of their mentions in social networks on the number of subsequent citations of these publications is considered. In particular, an analysis of some of such correlations is carried out on the example of 39 Russian translated journals of biological orientation distributed by the Springer Nature publishing house. Data from 2019–2021 was used regarding the number of article downloads, impact factors of editions, their SJR, CiteScore, SNIP, and usage factors. An analysis of the results obtained, as well as data available on the Internet, allowed the authors to conclude that the relationship between the number of downloads or altmetrics and the number of citations is not very strong, although it is quite reliable. It is emphasized that at present a large number of downloads / views of articles are carried out by users who are not engaged in science and, accordingly, do not write articles for academic journals. They are simply interested in scientific research results, and the Internet is now available to almost anyone. This also applies to the discussion of scientific publications in social networks. Apparently, the frequent mention of work in such networks really stimulates its downloads – however, this becomes obvious only if the article is an open access one, because the majority of “law-abiding” users of social networks do not have legal access to publications in subscription editions. The mentioned circumstances, according to the authors, will lead to a gradual weakening of the correlations considered in the article.
The Effect of Part-time Work, Work Stress, Learning Environment, Learning Motivation and on Academic Achievement of Student Employees in Management Study Program (Empirical Study at Pembangunan Panca Budi University)
Authors: Hidayatin Rahmadani
Published: February 2023

This research was conducted on Employee Students of the Management Study Program at Pembangunan Panca Budi University, Medan. The research objective is to identify and analyze the effect of part-time work, work stress, learning environment and learning motivation on academic achievement. The population in this study was 431 respondents who were Friday and Saturday Employee Class Students for the period 2020 to 2022. The number of samples taken in this study were 82 respondents. The sample size is determined by the Slovin formula with an error tolerance of 10%. This study uses quantitative data processed with the SPSS application with multiple linear regression analysis models. The data source used is primary data taken directly from the respondents. The results showed that part-time work, work stress and learning motivation had a positive and significant effect on academic achievement. While the Learning Environment has no effect and is not significant on Academic Achievement. Simultaneously Parttime Work, Work Stress, Learning Environment and Learning Motivation have a positive and significant effect on Academic Achievement. The magnitude of the influence contribution of all variables is 31.0% and the rest is influenced by other variables not examined in this study.
The Influence of the Work Environment, Commitment and Personality of UMKM on the Loyalty of Human Resources Through The Performance of UMKM in Klambir V Kebun Village
Authors: Sebayang Saimara AM , Ario Firman , Taufik Mahful
Published: February 2023

This study aims to analyze the effect of the work environment, commitment, personality of  UMKM  on HR loyalty through UMKM performance. The research was conducted in Kelambir Lima Kebun Village, Hamparan Perak District, Deli Serdang Regency. This type of research is associative research with quantitative descriptive method. The number of samples studied in this study were 50 respondents who were UMKM actors. Data analysis was carried out through PLS-SEM using the SmartPLS v. program. 3. The results of direct effect research show that the work environment, commitment and personality of  UMKM  have a positive and significant effect on UMKM performance. The personality of UMKM has a positive and significant effect on HR loyalty. The work environment has no positive and insignificant effect on HR loyalty. UMKM performance has a positive and significant effect on HR loyalty. While the results of the indirect effect research show that the work environment, commitment and personality of  UMKM  have a positive and significant effect on HR loyalty through UMKM performance.
Keynote Speaker to Participant Interaction in Online Webinar by Using Zoom Application
Authors: Dani Ersika Puspita , Agustin Angel , Deani Eliza
Published: February 2023

The objective of this descriptive qualitative study was to find out the keynote speaker to participant in online webinar by using zoom application. A keynote speaker has been conducted as a participant. To examine keynote speaker to participant, observation in zoom application were be used. The observation was be used to find out the keynote speaker’s interaction to participant. Then, the results were be analyzed to identify form of keynote speaker’s interaction. The results were 1) There were 3 forms of interaction used by keynote speaker to participant in online webinar, namely initiation move (I-Move), response move (R-Move), and Feedback Move (F-Move), and 2) The Initiation move (I-Move) was the most dominant interaction form used by keynote speaker to participant in online webinar and the least form was feedback move (F-Move).
Mortalidad en adultos mexicanos de 50 a 80 años de edad con multimorbilidad en un período de observación de 18 años
Authors: Novak Beatriz , Lozano Keymolen Daniel
Published: February 2023

El aumento de enfermedades crónicas en la población mexicana es uno de los principales problemas en el área de la salud. El objetivo de esta investigación es contribuir al estudio de la prevalencia de multimorbilidad en México y su efecto sobre la mortalidad por todas las causas en hombres y mujeres de 50 a 80 años de edad. Con datos del Estudio Nacional de Salud y Envejecimiento en México, 2001-2018, los modelos de riesgos proporcionales ajustados por variables socioeconómicas y de salud muestran que la multimorbilidad duplica el riesgo de muerte tanto de mujeres como de hombres, si se compara con el de sus pares sin multimorbilidad.
Leczenie chorego z zespołem objawów, a nie diagnoz – możliwości citalopramu
Authors: Gładka Anna , Rymaszewska Joanna
Published: February 2023

Citalopram to lek przeciwdepresyjny z grupy SSRI, który jest szeroko stosowany w depresji, zaburzeniach lękowych i problemach ze snem. Jego wysoka skuteczność w połączeniu z korzystnym profilem tolerancji sprawia, że może być stosowany u pacjentów starszych. W takich sytuacjach należy jednak pamiętać o dostosowaniu dawki do stanu pacjenta i unikaniu interakcji z innymi lekami często stosowanymi w tej grupie chorych. W pracy przedstawiono dwa opisy przypadków zastosowania citalopramu u chorych w trudnych sytuacjach diagnostycznych.
Duloksetyna – możliwości zastosowania w praktyce psychiatry – kieszonkowy przewodnik
Authors: Antosik-Wójcińska Anna
Published: February 2023

Celem artykułu jest pokazanie na przykładzie przypadków klinicznych możliwości zastosowania duloksetyny w codziennej praktyce lekarza psychiatry, neurologa oraz lekarza pierwszego kontaktu, jak również wyodrębnienie profilu pacjenta, który mógłby najbardziej skorzystać na terapii tym lekiem. Autorka dokonała podsumowania informacji dotyczących bezpieczeństwa i wskazań do stosowania duloksetyny, porównując ten lek do innych często stosowanych leków przeciwdepresyjnych. Opierając się na wynikach badań i doświadczeniach własnych w stosowaniu duloksetyny w różnych sytuacjach klinicznych i w różnych populacjach pacjentów, odniosła się także do najczęściej pojawiających się pytań i wątpliwości stanowiących barierę przed wdrożeniem przez lekarzy terapii duloksetyną.
ADT w raku prostaty 2022 – wybór czy konieczność?
Authors: Drobniak Artur , Malik Lesław
Published: February 2023

Rak prostaty jest coraz częściej występującym nowotworem złośliwym. Terapia opiera się na postępowaniu miejscowym (chirurgia, radioterapia) i leczeniu systemowym (hormonoterapia, chemioterapia). Deprywacja androgenowa odgrywa kluczową rolę w leczeniu raka stercza. Różne kombinacje leków pozwalają na coraz dłuższy czas życia pacjentów. W artykule przedstawiono wybrane zagadnienia związane z nowymi możliwościami leczenia w różnych stadiach choroby.