bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical Characterization, Antioxidant, Enzyme Inhibition and Antimutagenic Properties of Eight Mushroom Species: A Comparative Study
Authors: Alkan Sinan , Uysal Ahmet , Kasik Giyasettin , Vlaisavljevic Sanja , Berežni Sanja , Zengin Gokhan
Published: September 2020

This study aimed to determine the chemical composition and biologic activities of eight mushroom species (Amanita crocea, Hemileccinum depilatum, Cyclocybe cylindracea, Lactarius deliciosus, Hygrocybe acutoconica, Neoboletus erythropus, Russula aurea and Russula sanguinea). The antioxidant, enzyme inhibitory and mutagenic/antimutagenic activities were evaluated to provide data on the biologic activities. With respect to the chemical composition, LC–MS/MS technique was used to determine individual phenolic compounds present in the extracts. Antioxidant properties were investigated by different chemical methods including radical quenching (DPPH and ABTS), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating. In the enzyme inhibitory assays, cholinesterases, tyrosinase, amylase and glucosidase were used. Mutagenic and antimutagenic properties were evaluated by the Ames assay. In general, the best antioxidant abilities were observed from H. depilatum and N. erythropus, which also showed highest level of phenolics. The best cholinesterase inhibition ability was found from C. cylindracea (1.02 mg GALAE/g for AChE; 0.99 mg GALAE/g for BChE). Tyrosinase inhibition ability varied from 48.83 to 54.18 mg KAE/g. The extracts exhibited no mutagenic effects and showed significant antimutagenic potential. H. acutoconica, in particular depicted excellent antimutagenicity with a ratio of 97% for TA100 and with a rate of 96% for TA98 strain against mutagens in the presence of metabolic activation system. Results presented in this study tend to show that the mushroom species could be exploited as potential sources of therapeutic bioactive agents, geared towards the management of oxidative stress, global health problems and cancer.
Influence of SH2B3, MTHFD1L, GGCX, and ITGB3 Gene Polymorphisms on theVariability on Warfarin Dosage Requirements and Susceptibility to CVD in the Jordanian Population
Authors: AL-Eitan Laith N. , Almasri Ayah Y. , Khasawneh Rame H. , Alghamdi Mansour A.
Published: September 2020

The purpose of this study was to investigate the effects of the SH2B3, MTHFD1L, GGCX, and ITGB3 gene variants on the efficacy of warfarin treatment and its effects on the risk of cardiovascular disorders in Jordanian patients. The selected genes and their polymorphisms are involved in many Genome-Wide Association Study (GWAS) associated with cardiovascular disease and the variability of warfarin therapy. The current study conducted a genetic association and pharmacogenetics study in (212) Jordanian cardiovascular patients treated with warfarin and (213) healthy controls. DNA extraction and the Mass ARRAY™ system were used to genotype ten selected polymorphisms within four genes (SH2B3, MTHFD1L, GGCX, and ITGB3). This study confirmed a genetic association of MTHFD1L rs6922269 Single Nucleotide Polymorphism (SNP) with warfarin sensitivity during the initial and stabilization phases of treatment. Moreover, this SNP showed significant differences in the initial and maintenance doses of warfarin. This study also found an association between the genetic haplotypes (AGC and GAT) within the SH2B3 gene and responsiveness to warfarin. However, possession of an MTHFD1L rs491552 variant allele was found to affect the outcome measure of the international normalized ratio (INR) during the stabilization phase of warfarin treatment. In contrast, there was no association between all selected SNPs and susceptibility to cardiovascular disorders. This study extends the current understanding of the high variability of the warfarin response, including variability in dose requirements and susceptibility to cardiovascular disease in the Jordanian-Arab population. Other studies on a larger sample and in different ethnic groups could help to better understand the pharmacogenetics of warfarin and its application in personalized medicine.
Personalized Tests in Paralympic Athletes: Aerobic and Anaerobic Performance Profile of Elite Wheelchair Rugby Players
Authors: Marcolin Giuseppe , Petrone Nicola , Benazzato Michael , Bettella Francesco , Gottardi Angela , Salmaso Luigi , Corain Livio , Musumeci Alfredo , Masiero Stefano , Paoli Antonio
Published: September 2020

In Paralympic sports, the goal of functional classifications is to minimize the impact of impairment on the outcome of the competition. The present cross-sectional study aimed to investigate aerobic and anaerobic personalized tests in Paralympic athletes and to correlate them with the classification of the international wheelchair rugby federation (IWRF). Sixteen elite players of the Italian wheelchair rugby team volunteered for the study. Aerobic (incremental test to exhaustion) and anaerobic (Wingate 30s all-out test, 5 and 10-meter sprint test, shuttle test, isometric test) sport-performance measurements were correlated singularly or grouped (Z scores) with the classification point. Moreover, a multivariate permutation-based ranking analysis investigated possible differences in the overall level of performance among the adjacent classified groups of players, considering the scores of each test. A statistically significant correlation between the performance parameters and the IWRF functional classification considering both aerobic and anaerobic personalized tests was detected (0.58 ≤ r ≤ 0.88; 0.0260 ≤ p ≤ 0.0001). The multivariate permutation-based ranking analysis showed differences only for the low-pointers versus mid-pointers (p = 0.0195) and high-pointers (p = 0.0075). Although single performance parameters correlated with athletes’ classification point, results of the multivariate permutation-based ranking analysis seem to suggest considering only the most significant anaerobic and sport-specific performance parameters among athletes. These should be combined with the physical assessment and the qualitative observation, which are already part of the classification process to improve its effectiveness.
Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders
Authors: Bremner James Douglas , Gurel Nil Z. , Wittbrodt Matthew T. , Shandhi Mobashir H. , Rapaport Mark H. , Nye Jonathon A. , Pearce Bradley D. , Vaccarino Viola , Shah Amit J. , Park Jeanie , Bikson Marom , Inan Omer T.
Published: September 2020

Background: Vagal Nerve Stimulation (VNS) has been shown to be efficacious for the treatment of depression, but to date, VNS devices have required surgical implantation, which has limited widespread implementation. Methods: New noninvasive VNS (nVNS) devices have been developed which allow external stimulation of the vagus nerve, and their effects on physiology in patients with stress-related psychiatric disorders can be measured with brain imaging, blood biomarkers, and wearable sensing devices. Advantages in terms of cost and convenience may lead to more widespread implementation in psychiatry, as well as facilitate research of the physiology of the vagus nerve in humans. nVNS has effects on autonomic tone, cardiovascular function, inflammatory responses, and central brain areas involved in modulation of emotion, all of which make it particularly applicable to patients with stress-related psychiatric disorders, including posttraumatic stress disorder (PTSD) and depression, since dysregulation of these circuits and systems underlies the symptomatology of these disorders. Results: This paper reviewed the physiology of the vagus nerve and its relevance to modulating the stress response in the context of application of nVNS to stress-related psychiatric disorders. Conclusions: nVNS has a favorable effect on stress physiology that is measurable using brain imaging, blood biomarkers of inflammation, and wearable sensing devices, and shows promise in the prevention and treatment of stress-related psychiatric disorders.
Shannon Entropy Estimation for Linear Processes
Authors: Fortune Timothy , Sang Hailin
Published: September 2020

In this paper, we estimate the Shannon entropy S(f)=−E[log(f(x))] of a one-sided linear process with probability density function f(x). We employ the integral estimator Sn(f), which utilizes the standard kernel density estimator fn(x) of f(x). We show that Sn(f) converges to S(f) almost surely and in Ł2 under reasonable conditions.
An Orthogonal Air Pollution Monitoring Method (OAPM) Based on LoRaWAN
Authors: Haiahem Rahim , Minet Pascale , Boumerdassi Selma , Azouz Saidane Leila
Published: September 2020

High accuracy air pollution monitoring in a smart city requires the deployment of a huge number of sensors in this city. One of the most appropriate wireless technologies expected to support high density deployment is LoRaWAN which belongs to the Low Power Wide Area Network (LPWAN) family and offers long communication range, multi-year battery lifetime and low cost end devices. It has been designed for End Devices (EDs) and applications that need to send small amounts of data a few times per hour. However, a high number of end devices breaks the orthogonality of LoRaWAN transmissions, which was one of the main advantages of LoRaWAN. Hence, network performances are strongly impacted. To solve this problem, we propose a solution called OAPM (Orthogonal Air Pollution Monitoring) which ensures the orthogonality of LoRaWAN transmissions and provides accurate air pollution monitoring. In this paper, we show how to organize EDs into clusters and sub-clusters, assign transmission times to EDs, configurate and synchronize them, taking into account the specificities of LoRaWAN and the features of the air pollution monitoring application. Simulation results corroborate the very good behavior of OAPM.
An Overview of Bioinformatics Tools for DNA Meta-Barcoding Analysis of Microbial Communities of Bioaerosols: Digest for Microbiologists
Authors: Mbareche Hamza , Dumont-Leblond Nathan , Bilodeau Guillaume J. , Duchaine Caroline
Published: September 2020

High-throughput DNA sequencing (HTS) has changed our understanding of the microbial composition present in a wide range of environments. Applying HTS methods to air samples from different environments allows the identification and quantification (relative abundance) of the microorganisms present and gives a better understanding of human exposure to indoor and outdoor bioaerosols. To make full use of the avalanche of information made available by these sequences, repeated measurements must be taken, community composition described, error estimates made, correlations of microbiota with covariates (variables) must be examined, and increasingly sophisticated statistical tests must be conducted, all by using bioinformatics tools. Knowing which analysis to conduct and which tools to apply remains confusing for bioaerosol scientists, as a litany of tools and data resources are now available for characterizing microbial communities. The goal of this review paper is to offer a guided tour through the bioinformatics tools that are useful in studying the microbial ecology of bioaerosols. This work explains microbial ecology features like alpha and beta diversity, multivariate analyses, differential abundances, taxonomic analyses, visualization tools and statistical tests using bioinformatics tools for bioaerosol scientists new to the field. It illustrates and promotes the use of selected bioinformatic tools in the study of bioaerosols and serves as a good source for learning the “dos and don’ts” involved in conducting a precise microbial ecology study.
Recent Trends in Three-Dimensional Bioinks Based on Alginate for Biomedical Applications
Authors: Pahlevanzadeh Farnoosh , Mokhtari Hamidreza , Bakhsheshi-Rad Hamid Reza , Emadi Rahmatollah , Kharaziha Mahshid , Valiani Ali , Poursamar S. Ali , Ismail Ahmad Fauzi , RamaKrishna Seeram , Berto Filippo
Published: September 2020

Three-dimensional (3D) bioprinting is an appealing and revolutionary manufacturing approach for the accurate placement of biologics, such as living cells and extracellular matrix (ECM) components, in the form of a 3D hierarchical structure to fabricate synthetic multicellular tissues. Many synthetic and natural polymers are applied as cell printing bioinks. One of them, alginate (Alg), is an inexpensive biomaterial that is among the most examined hydrogel materials intended for vascular, cartilage, and bone tissue printing. It has also been studied pertaining to the liver, kidney, and skin, due to its excellent cell response and flexible gelation preparation through divalent ions including calcium. Nevertheless, Alg hydrogels possess certain negative aspects, including weak mechanical characteristics, poor printability, poor structural stability, and poor cell attachment, which may restrict its usage along with the 3D printing approach to prepare artificial tissue. In this review paper, we prepare the accessible materials to be able to encourage and boost new Alg-based bioink formulations with superior characteristics for upcoming purposes in drug delivery systems. Moreover, the major outcomes are discussed, and the outstanding concerns regarding this area and the scope for upcoming examination are outlined.
Ceramic-Heterostructure-Based Magnetoelectric Voltage Transformer with an Adjustable Transformation Ratio
Authors: Saveliev Dmitri , Chashin Dmitri , Fetisov Leonid , Shamonin Mikhail , Fetisov Yuri
Published: September 2020

A voltage transformer employing the magnetoelectric effect in a composite ceramic heterostructure with layers of a magnetostrictive nickel–cobalt ferrite and a piezoelectric lead zirconate–titanate is described. In contrast to electromagnetic and piezoelectric transformers, a unique feature of the presented transformer is the possibility of tuning the voltage transformation ratio K using a dc magnetic field. The dependences of the transformer characteristics on the frequency and the amplitude of the input voltage, the strength of the control magnetic field and the load resistance are investigated. The transformer operates in the voltage range between 0 and 112 V, and the voltage transformation ratio K is tuned between 0 and 14.1 when the control field H changes between 0 and 6.4 kA/m. The power at the transformer output reached 63 mW, and the power conversion efficiency was 34%. The methods for calculation of the frequency response, and the field and load characteristics of the transformer are proposed. The ways to improve performance characteristics of magnetoelectric transformers and their possible application areas are discussed.
Laser-Based Trace Gas Detection inside Hollow-Core Fibers: A Review
Authors: Nikodem Michal
Published: September 2020

Thanks to the guidance of an optical wave in air, hollow-core fibers may serve as sampling cells in an optical spectroscopic system. This paper reviews applications of hollow-core optical fibers to laser-based gas sensing. Three types of hollow-core fibers are discussed: Hollow capillary waveguides, photonic band-gap fibers, and negative curvature fibers. Their advantages and drawbacks when used for laser-based trace gas detection are analyzed. Various examples of experimental sensing systems demonstrated in the literature over the past 20 years are discussed.
Seismic Behavior of Steel Column Base with Slip-Friction Connections
Authors: Li Chengyu , Liu Qi , Li Gongwen
Published: September 2020

Traditional rigid column base connections are damaged to different degrees after an earthquake and the damage is generally nonrecoverable. Thus, the cost of repairing or dismantling is quite high. A new type of slip-friction column base connection is proposed in this paper, which aims to replace the yielding energy dissipation of the traditional column base connection by the sliding friction energy dissipation between the arc endplates, thus achieving the design objective of damage-free energy dissipation. Finite element simulation was conducted to study the hysteretic performance of the proposed connections considering different axial compression ratios. The research indicates that both kinds of the proposed connections show good energy dissipation behavior and the increase of axial compression force can increase the energy dissipation ability. It also shows that the two kinds of connections can achieve the objective of damage-free energy dissipation. For the proposed connection, future research is still needed such as corresponding tests in the laboratory, the effect of the connection on the whole structure, and the re-centering systems for the connections.
Assessment of Internal Structure of Spun Concrete Using Image Analysis and Physicochemical Methods
Authors: Michałek Jarosław , Sobótka Maciej
Published: September 2020

Taking into account the possibilities offered by two imaging methods, X-ray microcomputed tomography (µCT) and two-dimensional optical scanning, this article discusses the possibility of using these methods to assess the internal structure of spun concrete, particularly its composition after hardening. To demonstrate the performance of the approach based on imaging, laboratory techniques based on physical and chemical methods were used as verification. Comparison of obtained results of applied research methods was carried out on samples of spun concrete, characterized by a layered structure of the annular cross-section. Samples were taken from the power pole E10.5/6c (Strunobet-Migacz, Lewin Brzeski, Poland) made by one of the Polish manufacturers of prestressed concrete E-poles precast in steel molds. The validation shows that optical scanning followed by appropriate image analysis is an effective method for evaluation of the spun concrete internal structure. In addition, such analysis can significantly complement the results of laboratory methods used so far. In a fairly simple way, through the porosity image, it can reveal improperly selected parameters of concrete spinning such as speed and time, and, through the distribution of cement content in the cross-section of the element, it can indicate compliance with the requirement for corrosion durability of spun concrete. The research methodology presented in the paper can be used to improve the production process of poles made of spun concrete; it can be an effective tool for verifying concrete structure.
A Dynamic Programming Setting for Functionally Graded Thick-Walled Cylinders
Authors: Abdalla Hassan Mohamed Abdelalim , Casagrande Daniele , De Bona Francesco
Published: September 2020

Material property variation in non-homogeneous internally pressurized thick-walled cylinders is investigated within the context of dynamic programming theory. The material is assumed to be linear, elastic, isotropic, and functionally graded in the radial direction. Based on the plane stress hypothesis, a state space formulation is given and the optimal control problem is stated and solved by means of Pontryagin’s Principle for different objective functionals. Optimal Young’s modulus distribution is found to be piecewise linear along the radial domain. A brief digression on the possible existence of switching points is addressed. Finally, a numerical example is performed within a special class of derived optimal solutions, showing promising results in terms of equivalent stress reduction with respect to the most used variations in literature.
Drying Characteristics of Eucalyptus urophylla × E. grandis with Supercritical CO2
Authors: Zhang Jing-Wen , Liu Hong-Hai , Yang Hang , Yang Lin
Published: September 2020

Supercritical CO2 (ScCO2) is a drying medium with excellent solubility and mass transfer efficiency. Supercritical CO2 drying (SCD) can remove the water of wood rapidly and prevent a change of microstructure caused by capillary tension in the drying process. In this study, Eucalyptus urophylla × E. grandis specimens with lengths of 50 and 100 mm were dried with ScCO2. Conventional kiln drying (CKD) and oven-drying (OD) were used as control. After 1 h, the drying rate, shrinkage, moisture distribution, drying stress were measured to explore the influence of drying methods and specimen length for drying characteristics during the early drying stage. The results showed that compared with CKD and OD, water removal was the fastest under SCD, and the drying rate was nine times of CKD and one time of OD. The shrinkage of SCD was the lowest among the three drying methods. Moisture distribution of SCD and OD was uneven. The drying stress of SCD was relatively high, the drying stress index of it was almost five times of CKD and three times of OD. Regardless of the drying method, shorter specimens had a shorter drying period but greater drying defects than the long specimens.
The Phase Relations of the Co-Ni-In Ternary System at 673 K and 873 K and Magnetic Properties of Their Compounds
Authors: Yang Tonghan , He Wei , Chen Guojian , Zeng Weijing , Wang Jinzhi , Zeng Lingmin , Liang Jianlie
Published: September 2020

The phase relationships of the ternary Co-Ni-In system at 673 K and 873 K were investigated by means of powder X-ray diffraction, scanning electron microscopy equipped with energy dispersive spectroscopy, and optical microscopy. Though CoIn2 does not exist at 873 K, the ternary solid solution Co1−xNixIn2 exists at both 673 K and 873 K with different composition ranges. The Rietveld refinements were carried out to investigate the crystal structure of Co1−xNixIn2 (x = 0.540, and 0.580) and Ni2−xCoxIn3 (x = 0.200). The magnetization dependence of temperature (MT) curves of Ni2−xCoxIn3 (x = 0.200) and Co1−xNixIn2 (x = 0.540) are similar to those of the ferromagnetic shape memory alloys Ni-Mn-A (A = Ga, Sn, and In), but do not undergo martensitic transformation. The maximum magnetic entropy changes in Ni2−xCoxIn3 (x = 0.200) and Co1−xNixIn2 (x = 0.540) under 3T are 1.25 and 1.475 J kg−1K−1, respectively.
The Impact Behaviour of Crab Carapaces in Relation to Morphology
Authors: Sayekti Puspa Restu , Fahrunnida Fahrunnida , Cerniauskas Gabrielis , Robert Colin , Retnoaji Bambang , Alam Parvez
Published: September 2020

Brachyuran crab carapaces are protective, impact-resistant exoskeletons with elaborate material microstructures. Though several research efforts have been made to characterise the physical, material and mechanical properties of the crab carapace, there are no studies detailing how crab morphologies might influence impact resistance. The purpose of this paper is to characterise and compare Brachyuran crab carapace morphologies in relation to their impact properties, using opto-digital, experimental and numerical methods. We find that crab carapaces with both extended carapace arc-lengths and deep carapace grooves lose stiffness rapidly under cyclic impact loading, and fail in a brittle manner. Contrarily, carapaces with smaller arc lengths and shallower, more broadly distributed carapace grooves are more effective in dissipating stresses caused by impact throughout the carapace structure. This allows them to retain stiffness for longer, and influences their failure mode, which is ductile (denting), rather than brittle fracture. The findings in this paper provide new bioinspired approaches for the geometrical designs by which means material failure under cyclic impact can be controlled and manipulated.
Studying the Effect of Working Conditions on WEDM Machining Performance of Super Alloy Inconel 617
Authors: Dzionk Stefan , Siemiątkowski Mieczysław S.
Published: September 2020

Wire electrical discharge machining (WEDM) has been, for many years, a precise and efficient non-conventional manufacturing solution in various industrial applications, mostly involving the use of hard-to-machine materials like, among others, the Inconel super alloys. The focus of the present study is on exploring the effect of selected control parameters, including pulse duration, pulse-off time and the dielectric flow pressure on the WEDM process performance characteristics of Inconel 617 material, such as: volumetric material removal rate (MRR), the dimensional accuracy of cutting (reflected by the kerf width) and surface roughness (SR). The research experiment has been designed and carried out using the response surface methodology (RSM) accordingly with the Box–Behnken design scheme. The results of experiments derived in the form of a fitted regression model have been subjected to the analysis of variance (ANOVA) tests. Thus, the variable process parameters and the relevant interactions between them, characterized by a significant influence on the values of the derived output responses, could be explicitly determined.
Hydrogen Peroxide-Assisted Hydrothermal Synthesis of BiFeO3 Microspheres and Their Dielectric Behavior
Authors: Syed Asad , Siddaramanna Ashoka , Elgorban Abdallah M. , Hakeem D. A. , Nagaraju G.
Published: September 2020

Despite considerable efforts undertaken in a rapidly developing area of multiferroic research, synthesis of phase pure BiFeO3 is still a matter of intensive research. In this work, we report the shape-controlled synthesis of pure BiFeO3 microspheres via a facile hydrothermal route. The prepared BiFeO3 powder has been characterized using powder X-ray Diffraction (XRD), Differential Thermal analysis (DTA), Scanning Electron microscopy (SEM), and impedance spectroscopy. Powder XRD analysis confirms the formation of pure rhombohedrally distorted perovskite with R3c space group. Scanning electron micrograph revealed that the prepared BiFeO3 microspheres are nearly spherical in shape with uniform size distribution. The BiFeO3 microspheres exhibit a dielectric constant value of ~110 at 1000 KHz, which is higher than the BiFeO3 prepared by conventional solid-state reaction and sol–gel method. Variation of dielectric constant with temperature at different frequencies shows that the BiFeO3 has a dielectric anomaly of ferroelectric to paraelectric type at 1093 K and this phenomenon is well supported by TGA results.
The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation
Authors: Rudajev Vladimir , Novotny Jiri
Published: September 2020

Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and protection of neuronal tissue. It has, however, been demonstrated that GM1 plays a negative role in the pathophysiology of Alzheimer’s disease (AD). The two features of AD are the formation of intracellular neurofibrillary bodies and the accumulation of extracellular amyloid β (Aβ). Aβ is a peptide characterized by intrinsic conformational flexibility. Depending on its partners, Aβ can adopt different spatial arrangements. GM1 has been shown to induce specific changes in the spatial organization of Aβ, which lead to enhanced peptide accumulation and deleterious effect especially on neuronal membranes containing clusters of this ganglioside. Changes in GM1 levels and distribution during the development of AD may contribute to the aggravation of the disease.
Development of an Instrumented Test Tool for the Determination of Heat Transfer Coefficients for Die Casting Applications
Authors: Kouki Yosra , Müller Sebastian , Schuchardt Torsten , Dilger Klaus
Published: September 2020

In the case of casting processes with permanent molds, there is still a relatively pronounced lack of knowledge regarding the locally prevailing heat transfer between casts and mold. This in turn results in an insufficient knowledge of the microstructure and the associated material properties in the areas of the casting component close to the surface. Therefore, this work deals with the design and evaluation of a test tool with an integrated sensor system for temperature measurements, which was applied to obtain a time-dependent heat transfer coefficient (HTC) during casting solidification. For this purpose, the setup, design and computational approach are described first. Special attention is paid to the qualification of the multi-depth sensor and the calculation method. For the calculations, an inverse estimation method (nonlinear sequential function) was used to obtain the HTC profiles from the collected data. The developed sensor technology was used in a test mold to verify the usability of the sensor technology and the plausibility of the obtained calculation results under real casting conditions and associated temperature loads. Both the experimental temperature profiles and the HTC profiles showed that, in the evaluated casting series, the peak values determined were close to each other and reached values between 6000 W/(m2·K) and 8000 W/(m2·K) during solidification.
Effects of High-Temperature Tempering on Mechanical Properties and Microstructure of SA738 Gr.B Steel
Authors: Li Yanmei , Zhang Shuzhan , Zhao Chunyao , Song Minghui , Jiang Zaiwei
Published: September 2020

In this paper, JMatPro thermodynamic software, OM, SEM, TEM, and EPMA were used to study the microstructure and mechanical properties of SA738 Gr.B nuclear power steel after tempering at 630–710 °C. When tempered within the range of 630–670 °C, a huge amount of M3C and MC carbides were dispersed and precipitated in the ferrite matrix, and the strength and toughness matched well; when the tempering temperature rose above 670 °C, hard and brittle plate-martensites formed at the grain boundary, leading to the tensile strength of the experimental steel increased, while the low-temperature impact toughness significantly decreased and the yield strength also declined due to the disappearance of the finely dispersed second phase particles in the matrix.
The Effects of Inhomogeneous Elasticity and Dislocation on Thermodynamics and the Kinetics of the Spinodal Decomposition of a Fe-Cr System: A Phase-Field Study
Authors: Shin Wooseob , Lee Jeonghwan , Chang Kunok
Published: September 2020

The effects of inhomogeneous elasticity and dislocation on the microstructure evolution of α′ precipitate in a Fe-Cr system was investigated using a Computer Coupling of Phase Diagrams and Thermochemistry (CALPHAD)-type free energy incorporated phase-field method. In order to simulate the precipitation behavior by phase-field modeling in consideration of inhomogeneous elasticity, a Multiphysics Object-Oriented Simulation Environment (MOOSE) framework was used, which makes it easy to use powerful numerical means such as parallel computing and finite element method (FEM) solver. The effect of inhomogeneous elasticity due to the compositional inhomogeneity or the presence of dislocations affects the thermodynamic properties of the system was investigated, such as the lowest Cr concentration at which spinodal decomposition occurs. The effect of inhomogeneous elasticity on phase separation kinetics is also studied. Finally, we analyzed how inhomogeneous elasticity caused by compositional fluctuation or dislocation affects microstructure characteristics such as ratio between maximum precipitate size with respect to the average on early stage and later stage, respectively.
Mathematical Modelling of Multiphase Flow and Inclusion Behavior in a Single-Strand Tundish
Authors: Sheng Dong-Yuan
Published: September 2020

A mathematical model was developed to study the effects of the flow control devices and the gas curtain on the steel cleanness in a single-strand tundish. The Eulerian–Lagrangian approach was applied to investigate the bubble flow and the behavior of the non-metallic inclusions in the system. Two modelling approaches were considered: (i) one-way coupling, where the influence of the micro-inclusion on the molten steel flow is neglected; and (ii) two-way coupling, where the momentum exchange between the molten steel and the bubbles is modelled. The model verification and validation (V&V) were carried out in order to establish confidence in the model predictions. Four different tundish configurations and the effect of various parameters, such as the inclusion size, the inclusion density and the gas flow rate, were investigated at the normal casting conditions. The results show that the flow control devices and the gas curtain reduce the extent of the dead volumes in the tundish and thus enhance the removal efficiency of the inclusions. Controlling the gas stirring intensity is important for tundish operation with the aim of removing the inclusions. Theoretical analysis suggests that small bubbles are preferable to increase the inclusion removal rate in industrial operations.
Preliminary Study on Polishing SLA 3D-Printed ABS-Like Resins for Surface Roughness and Glossiness Reduction
Authors: Son Jungyu , Lee Hyunseop
Published: September 2020

After the development of 3D printing, the post-processing of the 3D-printed materials has been continuously studied, and with the recent expansion of the application of 3D printing, interest in it is increasing. Among various surface-machining processes, chemical mechanical polishing (CMP) is a technology that can effectively provide a fine surface via chemical reactions and mechanical material removal. In this study, two polishing methods were evaluated for the reduction of surface roughness and glossiness of a stereolithography apparatus (SLA) 3D-printed ABS (acrylonitrile butadiene styrene)-like resin. Experiments were conducted on the application of CMP directly to the 3D-printed ABS-like resin (one-step polishing), and on the application of sanding (#2000) and CMP sequentially (two-step polishing). The one-step polishing experiments showed that it took a considerable period of time to remove waviness on the surface of the as-3D printed specimen using CMP. However, in the case of two-step polishing, surface roughness was reduced, and glossiness was increased faster than in the case of one-step polishing via sanding and CMP. Consequently, the experimental results show that the two-step polishing method reduced roughness more efficiently than the one-step polishing method.
Disease, Drugs and Dysbiosis: Understanding Microbial Signatures in Metabolic Disease and Medical Interventions
Authors: Proffitt Ceri , Bidkhori Gholamreza , Moyes David , Shoaie Saeed
Published: September 2020

Since the discovery of the potential role for the gut microbiota in health and disease, many studies have gone on to report its impact in various pathologies. These studies have fuelled interest in the microbiome as a potential new target for treating disease Here, we reviewed the key metabolic diseases, obesity, type 2 diabetes and atherosclerosis and the role of the microbiome in their pathogenesis. In particular, we will discuss disease associated microbial dysbiosis; the shift in the microbiome caused by medical interventions and the altered metabolite levels between diseases and interventions. The microbial dysbiosis seen was compared between diseases including Crohn’s disease and ulcerative colitis, non-alcoholic fatty liver disease, liver cirrhosis and neurodegenerative diseases, Alzheimer’s and Parkinson’s. This review highlights the commonalities and differences in dysbiosis of the gut between diseases, along with metabolite levels in metabolic disease vs. the levels reported after an intervention. We identify the need for further analysis using systems biology approaches and discuss the potential need for treatments to consider their impact on the microbiome.
Distribution of Selenium in the Soil–Plant–Groundwater System: Factors Controlling Its Bio-Accumulation
Authors: Eliopoulos George D. , Eliopoulos Ioannis-Porfyrios D. , Tsioubri Myrto , Economou-Eliopoulos Maria
Published: September 2020

Selenium (Se) is an essential micronutrient for humans and animals, but both Se excess and deficiency can cause various health risks. Since Greece is among the European countries where people have very low Se-serum, the present study is focused on the Se distribution in cultivated and non-cultivated plants and relative soil coming from the Neogene basins of Greece (Assopos-Thiva and Attica), aiming to define potential Se-source/es and factors controlling Se bio-accumulation and enrichment in food. The dry weight Se values are relatively low (0.1–0.9 mg/kg) with the highest Se contents in garlic, beet and lettuce from the Assopos basin, where the translocation percentage [(mplant/msoil) × 100] for Se, P and S is much higher compared to non-cultivated Attica basin. There is a diversity between the Se source in soil and coastal groundwater which is used for irrigation in the cultivated Assopos–Thiva basin. The soil pH and oxidizing conditions (Eh) are considered the main driving force to make Se available for plant uptake. Potential sources for Se in Greece are Fe-Cu-Zn-sulphide ores and peat deposits in northern Greece, with a Se content ranging from decades to hundreds of mg/kg. Application of the leaching testing protocol is necessary to select the most appropriate proportion of additives to improve the Se deficiencies in agricultural soil.
The Effect of Co-Crystallising Sulphides and Precipitation Mechanisms on Sphalerite Geochemistry: A Case Study from the Hilton Zn-Pb (Ag) Deposit, Australia
Authors: Cave Bradley , Lilly Richard , Hong Wei
Published: September 2020

High-tech metals including Ge, Ga and In are often sourced as by-products from a range of ore minerals, including sphalerite from Zn-Pb deposits. The Hilton Zn-Pb (Ag) deposit in the Mount Isa Inlier, Queensland, contains six textural varieties of sphalerite that have formed through a diverse range of processes with variable co-crystallising sulphides. This textural complexity provides a unique opportunity to examine the effects of co-crystallising sulphides and chemical remobilisation on the trace element geochemistry of sphalerite. Early sphalerite (sph-1) is stratabound and coeval with pyrrhotite, pyrite and galena. Disseminated sphalerite (sph-2) occurs as isolated fine-grained laths rarely associated with co-crystallising sulphides and represents an alteration selvage accompanying the precipitation of early stratabound sphalerite (sph-1). Sphalerite (sph-3) occurs in early ferroan-dolomite veins and formed from the chemical remobilisation of stratabound sphalerite (sph-1) during brittle fracturing and interstitial fluid flow. This generation of veins terminate at the interface, and occurs within clasts of the paragenetically later sphalerite-dominated breccias (sph-4). Regions of high-grade Cu (>2%) mineralisation contain a late generation of sphalerite (sph-5), which formed from the recrystallisation of breccia-type sphalerite (sph-4) during the infiltration of a paragenetically late Cu- and Pb-rich fluid. Late ferroan-dolomite veins crosscut all previous stages of mineralisation and also contain chemically remobilised sphalerite (sph-6). Major and trace elements including Fe, Co, In, Sn, Sb, Ag and Tl are depleted in sphalerite associated with abundant co-crystallised neighbouring sulphides (e.g., pyrite, pyrrhotite, galena and chalcopyrite) relative to sphalerite associated with minor to no co-crystallising sulphides. This depletion is attributed to the incorporation of the trace elements into the competing sulphide minerals. Chemically remobilised sphalerite is enriched in Zn, Cd, Ge, Ga and Sn, and depleted in Fe, Tl, Co, Bi and occasionally Ag, Sb and Mn relative to the primary minerals. This is attributed to the higher mobility of Zn, Ge, Ga and Sn relative to Fe and Co during the chemical remobilisation process, coupled with the effect of co-crystallising with galena and ferroan-dolomite. Results from this study indicate that the consideration of co-crystallising sulphides and post-depositional processes are important in understanding the trace element composition of sphalerite on both a microscopic and deposit-scale, and has implications for a range of Zn-Pb deposits worldwide.
Plasma-Assisted Synthesis of Platinum Nitride Nanoparticles under HPHT: Realized by Carbon-Encapsulated Ultrafine Pt Nanoparticles
Authors: Zhang Jian , Lin Lin , Cui Hang
Published: September 2020

Noble metal nitrides (NMNs) have important theoretical significance and potential application prospects due to their high bulk modulus and remarkable electrical properties. However, NMNs can only be synthesized under extreme conditions of ultrahigh pressure and temperature, and nanoscaled NMNs have not been reported. In this work, as typical NMNs, PtNx nanoparticles were synthesized at 5 GPa and 750 K by the method of plasma-assisted laser-heating diamond anvil cell. The significantly reduced synthesis condition benefited from the ingenious design of the precursor and the remarkable chemical activity of the ultrafine Pt nanoparticles. This study, combining nanomaterials with high-pressure and -temperature (HPHT) techniques, provides a novel process for the preparation of NMN nanomaterials, and a new direction for the synthesis of superhard materials.
Smart ECM-Based Electrospun Biomaterials for Skeletal Muscle Regeneration
Authors: Politi Sara , Carotenuto Felicia , Rinaldi Antonio , Di Nardo Paolo , Manzari Vittorio , Albertini Maria Cristina , Araneo Rodolfo , Ramakrishna Seeram , Teodori Laura
Published: September 2020

The development of smart and intelligent regenerative biomaterials for skeletal muscle tissue engineering is an ongoing challenge, owing to the requirement of achieving biomimetic systems able to communicate biological signals and thus promote optimal tissue regeneration. Electrospinning is a well-known technique to produce fibers that mimic the three dimensional microstructural arrangements, down to nanoscale and the properties of the extracellular matrix fibers. Natural and synthetic polymers are used in the electrospinning process; moreover, a blend of them provides composite materials that have demonstrated the potential advantage of supporting cell function and adhesion. Recently, the decellularized extracellular matrix (dECM), which is the noncellular component of tissue that retains relevant biological cues for cells, has been evaluated as a starting biomaterial to realize composite electrospun constructs. The properties of the electrospun systems can be further improved with innovative procedures of functionalization with biomolecules. Among the various approaches, great attention is devoted to the “click” concept in constructing a bioactive system, due to the modularity, orthogonality, and simplicity features of the “click” reactions. In this paper, we first provide an overview of current approaches that can be used to obtain biofunctional composite electrospun biomaterials. Finally, we propose a design of composite electrospun biomaterials suitable for skeletal muscle tissue regeneration.
Graphene Platelets-Based Magnetoactive Materials with Tunable Magnetoelectric and Magnetodielectric Properties
Authors: Bica Ioan , Anitas Eugen Mircea
Published: September 2020

We fabricate hybrid magnetoactive materials (hMAMs) based on cotton fibers, silicone oil, carbonyl iron and graphene nanoplatelets (nGr) at various mass concentrations ΦnGr. The obtained materials are used as dielectric materials for manufacturing plane electrical capacitors. The equivalent electrical capacitance Cp and resistance Rp are measured in an electric field of medium frequency f, without and respectively with a magnetic field of magnetic flux density B in the range from 0.1 T up to 0.5 T. The results are used to extract the components ϵr′ and ϵr″ of the complex relative permittivity ϵr*, and to reveal the magnitude of the induced magnetoelectric couplings kx and magnetodielectric effects MDE. It is shown that ϵr′, ϵr″, kx and MDE are significantly influenced by f,B and ΦnGr. We describe the underlying physical mechanisms in the framework of dipolar approximation and using elements of dielectric theory. The tunable magnetoelectric and magnetodielectric properties of hMAMs are useful for manufacturing electrical devices for electromagnetic shielding of living organisms.
Acyclovir-Loaded Solid Lipid Nanoparticles: Optimization, Characterization and Evaluation of Its Pharmacokinetic Profile
Authors: Hassan Haniza , Bello Ramatu Omenesa , Adam Siti Khadijah , Alias Ekram , Meor Mohd Affandi Meor Mohd Redzuan , Shamsuddin Ahmad Fuad , Basir Rusliza
Published: September 2020

Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy. Moreover, the current therapeutic regimen of acyclovir is associated with unwarranted adverse effects, hence prompting the need for a suitable drug carrier to overcome these limitations. This study aimed to develop solid lipid nanoparticles (SLNs) as acyclovir carriers and evaluate their in vivo pharmacokinetic parameters to prove the study hypothesis. During the SLN development process, response surface methodology was exploited to optimize the composition of solid lipid and surfactant. Optimum combination of Biogapress Vegetal 297 ATO and Tween 80 was found essential to produce SLNs of 134 nm. The oral bioavailability study showed that acyclovir-loaded SLNs possessed superior oral bioavailability when compared with the commercial acyclovir suspension. The plasma concentration of acyclovir-loaded SLNs was four-fold higher than the commercial suspension. Thus, this investigation presented promising results that the method developed for encapsulation of acyclovir offers potential as an alternative pathway to enhance the drug’s bioavailability. In conclusion, this study exhibited the feasibility of SLNs as an oral delivery vehicle for acyclovir and therefore represents a new promising therapeutic concept of acyclovir treatment via a nanoparticulate drug delivery system.
Evaluating the Effect of Varying the Metal Precursor in the Colloidal Synthesis of MoSe2 Nanomaterials and Their Application as Electrodes in the Hydrogen Evolution Reaction
Authors: Ndala Zakhele , Shumbula Ndivhuwo , Nkabinde Siyabonga , Kolokoto Tshwarela , Nchoe Obakeng , Shumbula Poslet , Tetana Zikhona N. , Linganiso Ella C. , Gqoba Siziwe S. , Moloto Nosipho
Published: September 2020

Herein we report on the use of different metal precursors in the synthesis of MoSe2 nanomaterials in order to control their morphology. The use of Mo(CO)6 as the metal precursor resulted in the formation of wrinkled few-layer nanosheets, while the use of H2MoO4 as the metal precursor resulted in the formation of nanoflowers. To investigate the effect of the morphologies on their performance as catalysts in the hydrogen evolution reaction, electrochemical characterization was done using linear sweep voltammetry (LSV), cyclic voltammetry (CV), and electrical impedance spectroscopy (EIS). The MoSe2 nanoflowers were found to have superior electrochemical performance towards the hydrogen evolution reaction with a lower Tafel slope, on-set potential, and overpotential at 10 mA/cm2 compared to the wrinkled few-layer nanosheets. This was found to be due to the higher effective electrochemical surface area of the nanoflowers compared to the nanosheets which suggests a higher number of exposed edge sites in the nanoflowers.
Sulpho-Salicylic Acid Grafted to Ferrite Nanoparticles for n-Type Organic Semiconductors
Authors: Ravariu Cristian , Mihaiescu Dan , Morosan Alina , Vasile Bogdan Stefan , Purcareanu Bogdan
Published: September 2020

A disadvantage of the use of pentacene and typical organic materials in electronics is that their precursors are toxic for manufacturers and the environment. To the best of our knowledge, this is the first report of an n-type non-toxic semiconductor for organic transistors that uses sulpho-salicylic acid—a stable, electron-donating compound with reduced toxicity—grafted on a ferrite core–shell and a green synthesis method. The micro-physical characterization indicated a good dispersion stability and homogeneity of the obtained nanofilms using the dip-coating technique. The in-situ electrical characterization was based on a point-contact transistor configuration, and the increase in the drain current as the positive gate voltage increased proved the functionality of the n-type semiconductor.