bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistem Informasi BKK SMK Islamiyah Adiwerna Menggunakan PHP dan MySQL Berbasis Website
Authors: Fitriatunisa Wilda , Setyani Wahyu Prasetywati Aries
Published: January 2025

SMK Islamiyah Adiwerna adalah sekolah kejuruan swasta yang ada diKabupaten Tegal tepatnya di Kecamatan Adiwerna. SMK Islamiyah Adiwernamemiliki BKK, pada BKK Islamiyah Adiwerna sistem pendaftarannya masihsecara konvensional, yaitu pelamar data ke BKK Islamiyah dengan membawapersyaratan dan pelamar mengisi identitas di daftar pelamar dan akan dimasukan ke grub WhatsApp. Dengan menggunakan sistem tersebut tentunyakurang efektif. Karena pelamar harus pergi ke BKK SMK Islamiyah Adiwernadan Admin harus menginput satu per satu data pelamar. Dalam penelitian inimetode analisis sistem melalui 3 tahapan yaitu : 1) survei terhadap sistem yangsedang berjalan 2) analisis terhadap temuan survey 3) identifikasi persyaratansistem. Adapun perancangan sistem berorientasi pada objek yaitu denganmenggunakan UML yang terdiri : 1) Use Case 2) Activity Diagram 3) SequenceDiagram 4) Class Diagram. Sistem informasi BKK ini berbasis website denganmenggunakan php dan MySQL. Dapat ditarik kesimpulan dengan adanyapenelitian ini menghasilkan perancangan dengan 2 aktor yaitu Calon Pekerjadan Admin BKK. Dengan adanya sistem ini diharapkan para pelamar kerja danadmin bkk bisa bekerja lebih efektif. Sistem BKK ini berbasis website karenaagar bisa di akses semua orang tanpa harus menginstall sistem
The Impact of Elementary Students' Attitudes Toward Online Learning on Memory Retention and Comprehension During the COVID-19 Pandemic: An Exploratory Study in Yogyakarta, Indonesia
Authors: Munastiwi Erni , Marpuah Siti
Published: January 2025

Purpose – This study aims to investigate elementary school students' attitudes toward online learning during the COVID-19 pandemic, focusing on the relationship between their attitudes and cognitive outcomes such as memory retention and comprehension. The goal is to enhance understanding of how psychological factors influence the effectiveness of online education and contribute to strategies for improving educational practices in remote environments.
Methods/Design/Approach – An exploratory research design was employed, using a structured survey distributed to 906 students from eight elementary schools in Yogyakarta, Indonesia. Data were collected through online questionnaires assessing attitudes toward online learning, memory retention, and comprehension abilities. Descriptive statistics and Pearson’s correlation coefficient were used to analyze the data, identifying relationships between students' attitudes and cognitive outcomes.
Findings – The study found that 52.65% of students had a negative attitude towards online learning. Students with positive attitudes exhibited better memory retention and comprehension, while those with negative attitudes showed significant challenges in these areas. The relationship between attitude and memory retention was statistically significant (χ² = 71.619, p < 0.001), as was the relationship between attitude and comprehension (χ² = 143.686, p < 0.001).
Originality/Value – This research adds to the limited studies on the psychological impact of online learning on younger students, offering insights into how attitudes shape cognitive performance in remote education environments. It emphasizes the importance of fostering positive attitudes to improve educational outcomes in online settings.
Practical Implications – The findings suggest that educational interventions should focus on improving students' attitudes towards online learning to enhance cognitive engagement and performance. Incorporating blended learning models and more interactive, engaging online experiences could better support young learners in remote education environments.
Keywords Online learning, elementary education, attitudes, memory retention, comprehension.
Paper type Research paper
Instructional Modifications in Inclusive Early Childhood Education: A Case Study of Teaching Strategies for Children with Autism in Yogyakarta
Authors: Maulidah Winda Syafaatin , Mufalakhah Kurnia
Published: January 2025

Purpose – This study investigates the application and effectiveness of instructional modifications in an inclusive classroom, specifically focusing on a child with autism, at TK ABA Karanganyar, Yogyakarta. The research addresses the knowledge gap in inclusive education by exploring how teaching strategies can be adapted to meet the diverse needs of students, particularly children with special needs (CSN), and foster their academic and social development..
Design/Methods/Approach – A qualitative case study method was employed, utilizing semi-structured interviews, direct classroom observations, and document analysis. Data were collected from the classroom teacher, principal, and students, including one child with autism, over multiple observation sessions. Analysis was conducted using Miles and Huberman's interactive model, ensuring data triangulation through cross-referencing interviews, observations, and school documents.
Findings – The study found that flexible and individualized instructional modifications—such as adapting learning activities and providing intensive assistance—promote engagement and development in children with special needs. These modifications not only support the child with autism but also enhance peer interactions, fostering a more inclusive classroom environment. However, resource constraints, including the lack of specialized aides and visual tools, were identified as challenges in fully implementing inclusive strategies.
Originality/Value – This research contributes to the literature by demonstrating that effective inclusive education can be achieved through teacher-initiated instructional modifications, even in the absence of formal inclusion programs. The findings provide valuable insights into creating inclusive environments in resource-limited settings, emphasizing teacher flexibility and creativity.
Practical Implications – The results offer practical recommendations for educators on implementing flexible, needs-based strategies in inclusive classrooms. Policymakers are encouraged to support inclusive education through targeted teacher training and resource allocation.
Keywords Inclusive education, instructional modification, early childhood, autism.
Paper type Research paper
Evaluating the Impact of Ethnomathematics on Mathematics Achievement: A Meta-Analysis of Studies from 2014-2024
Authors: Putri Linda Indiyarti , Begimbetova Guldana , Sa’idah Nusrotus , Murfi Ali
Published: January 2025

Purpose –  This study aims to address the persistent challenge of low mathematics comprehension among students, often attributed to culturally irrelevant and formal approaches in teaching. Despite the potential of ethnomathematics as a culturally contextualized pedagogical approach, comprehensive evaluations of its effectiveness remain limited. This research seeks to fill this gap by conducting a meta-analysis to measure the effect size of ethnomathematics in improving mathematics education over the past decade.
Methods/Design/Approach – A meta-analysis was conducted using data from 11 selected studies published between 2014 and 2024, which employed ethnomathematics in educational settings. The studies were screened based on rigorous inclusion criteria, focusing on experimental designs with control groups and sufficient statistical data for effect size calculation. Statistical analyses, including heterogeneity tests and publication bias assessments, were performed using JASP software.
Findings – The meta-analysis revealed that ethnomathematics significantly enhances students' mathematics achievement, with effect sizes ranging from 0.561 to 2.698. The average effect size of 1.22 indicates a strong positive impact, demonstrating that ethnomathematics is a highly effective approach in various educational contexts, including Indonesia and Zimbabwe. The analysis also identified some heterogeneity across studies, suggesting that the effectiveness of ethnomathematics may be influenced by factors such as intervention design and population characteristics.
Originality/Value – This study provides empirical evidence supporting the effectiveness of ethnomathematics as a pedagogical approach that bridges cultural contexts and mathematical concepts, enriching the curriculum and enhancing students' understanding. It contributes to the growing body of literature by validating ethnomathematics as a viable strategy for improving mathematics education, particularly in culturally diverse settings.
Practical Implications – The findings suggest that educators should consider integrating ethnomathematics into their teaching practices to make mathematics more relevant and engaging for students. The study also underscores the need for curriculum developers to incorporate cultural contexts into mathematics education, fostering inclusivity and relevance.
Keywords Ethnomathematics, mathematics education, meta-analysis, cultural context, educational effectiveness
Paper type Research paper
The Impact of AUN-QA Certification on Strengthening Internal Quality Assurance Systems in Indonesian Higher Education: A Comparative Study of Mechanical Engineering Programs
Authors: Fitriyani  , Prihatiningsih Titi Savitri , Supartono Wahyu
Published: January 2025

Purpose –  This study aims to evaluate the impact of AUN-QA (ASEAN University Network-Quality Assurance) certification on strengthening Internal Quality Assurance Systems (SPMI) in Indonesian higher education institutions, specifically in relation to aligning educational outcomes with industry needs. Given Indonesia’s global competitiveness ranking and challenges in aligning higher education with labor market demands, the research focuses on how AUN-QA certification affects quality assurance practices at the program level, aiming to close methodological and empirical gaps in the literature on quality assurance in Indonesian universities.
Methods/Design/Approach – A comparative case study approach is used, focusing on two Mechanical Engineering programs at Universitas Gadjah Mada (UGM) and Universitas Sebelas Maret (UNS), which have and have not attained AUN-QA certification. Qualitative data collection was conducted through semi-structured interviews and document analysis, with participants involved in SPMI implementation. Thematic analysis was employed to identify patterns and themes regarding understanding, implementation, and commitment to SPMI and its alignment with industry needs.
Findings – AUN-QA certification enhances the effectiveness of SPMI, promoting better alignment between educational outcomes and industry demands. UGM's certified program showed significant improvements in curriculum development, student outcome measurement, and stakeholder engagement compared to the non-certified program at UNS. However, challenges remain in fully integrating international standards into SPMI practices..
Originality/Value – This study provides empirical evidence on the positive impact of international certification on quality assurance in Indonesian higher education, offering insights into how AUN-QA certification can drive continuous quality improvement and closer alignment with industry expectations, addressing gaps in both theoretical and practical knowledge.
Practical Implications – The findings suggest that higher education institutions should prioritize internal quality assurance alongside international certification to produce industry-relevant graduates. Policymakers and university administrators are encouraged to support the adoption of AUN-QA and similar certifications to enhance the global competitiveness of Indonesian graduates..
Keywords AUN-QA certification, internal quality assurance, higher education, industry alignment, curriculum development, Indonesia
Paper type Research paper
Pendampingan Labelisasi dan Pencatatan Koleksi Perpustakaan Pada Perpustakaan Sekolah
Authors: Muhammad Muhammad , Latifah Ainur , Nurjannah Eva
Published: January 2025

This community service is carried out in the library of SMP Negeri 2 Sangatta Utara in the form of assistance in managing library book collections. The aim is to assist in inventorying, classifying, inputting data, labeling, and compiling the library book collection of SMP Negeri 2 Sangatta Utara. The method used in this service is a participatory Action Research research method. Participatory Action Research is a service research activity where the author is directly involved in a participatory manner as a mentor at the service location. The results are: First, the library at SMP Negeri 2 Sangatta Utara is still lacking in book collections where most of the existing book collections are textbooks according to class. Second, the arrangement of the books is still irregular so that in the shelving process we rearrange the previous books based on their classification. Third, the data input is still in the form of a ledger where if you look at the modern situation, almost all activities have been done digitally. It is hoped that further PkM activities can contribute more in fulfilling book collections and library management.
Workshop Analisis dan Interprestasi Hasil Uji Statistik Menggunakan SMART PLS 3.2.8
Authors: Leovita Angelia , Resti Siska , Martadona Ilham
Published: January 2025

Workshop activities are carried out as a result of advances in information technology, data processing becomes a very crucial thing, especially in the context of research and development of science. Where the need for science and knowledge is increasing in mastering the software used in data analysis of a study. This activity aims to increase participants' knowledge of the concept of Structural Equation Modeling with parameter estimation using the Partial Least Square (SEM-PLS) method, (2) Improve participants' ability to process data using the Smart-PLS data processing application, (3) Interpret the results of data processing or output from the software in order to improve the quality of research. The method used is the lecture and practice method. The number of participants who attended the workshop was 23 people consisting of academics and students. The results of the training showed an increase in participants' understanding and their ability to use SMART PLS. The conclusion of this training is that mastery of PLS-SEM is important for improving the quality of research, and this kind of training can contribute positively to research.
Peran Partisipasi Masyarakat Dalam Pendidikan Di Kawasan RT. 30 Sangatta Utara
Authors: Hidayah Nur Fitri , Sairah Nor , Yasin Muhammad
Published: January 2025

Community participation Refers to the involvement of individuals in activities or processes that influence life together in a community or society. This can include a variety of things, from political participation to participation in social organizations, volunteer activities, education, and more. This research uses a qualitative approach. Data collection uses observation, interviews and documentation. The research was conducted with the aim of finding out what role educational participation plays in society? What are the forms of community participation in educational development in the RT. 30 community area? The role of community participation and schools is required to work together effectively to improve educational standards. For the sake of progress and education of students, schools and communities are also expected to share information, ideas and opinions. because it is becoming more advanced due to advances in science and forms of participation in the form of holding meetings, before announcing the amount of the committee fee, the school will usually hold a parent meeting, socialization between teachers and parents of students and is usually led directly by the head of the community. Forms of Community Participation in the Development of Education in the RT. 30 Community Area Apart from the government, parents and the community also have a responsibility to educate their children.
Implementasi Manajemen Kurikulum Merdeka Belajar Dalam Menciptakan Profil Pelajar Pancasila di SMA Negeri 2 Muara Wahau
Authors: Septiani Retno , Satriah Satriah , Munfiatik Siti
Published: January 2025

This research aims to explain the implementation of the Merdeka Belajar curriculum management in creating Pancasila Student profiles, identify obstacles in the implementation of the Merdeka Belajar curriculum management, and explore the efforts made to overcome challenges in the implementation of the Merdeka Belajar curriculum management at SMA Negeri 2 Muara Wahau. This research uses a qualitative approach with the type of field research, which was carried out at SMA Negeri 2 Muara Wahau. The research informants consisted of the school principal, deputy principal for curriculum, and driving teachers. The data collection techniques used included observation, interviews and documentation, which were analyzed descriptively qualitatively based on the Miles and Huberman data analysis model. The results of the research show that the implementation of the Merdeka Belajar curriculum management at SMA Negeri 2 Muara Wahau has gone well, referring to the management function POAC (Planning, Organizing, Actuating, Controlling), although there are obstacles related to understanding the concepts and objectives of the Merdeka Belajar curriculum which are still limited in among teachers, students and parents. Another obstacle is related to teachers' difficulties in determining appropriate learning methods. The proposed solution to overcome these obstacles is to involve all stakeholders in offline and online training, which aims to increase teachers' understanding of the core Merdeka Belajar curriculum and improve teachers' abilities in implementing innovative teaching methods. Apart from that, outreach to students' parents was also carried out to introduce the Merdeka Belajar curriculum in more depth.
Kristus Dalam Nubuatan Perjanjian Lama
Authors: Sunkudon Pieter G.O.
Published: January 2025

There are so many prophecies about the Messiah/Christ in the Old Testament. This fact is very reasonable, considering the entire Bible message is centered on the promise of restoration through Christ. Understand the fundamental interests of the prophecies about Christ can be said to be urgent, because it relates to one of the fundamental doctrines of Christianity. This descriptive article discusses the Old Testament prophecies concerning the Messiah/Christ completely fulfilled in Jesus.
Incarner la pietà pour contester l’histoire : les sculptures mémorielles de Tavares Strachan
Authors: Dietschy Nathalie
Published: January 2025

Cet article interroge les incarnations d’oeuvres d’art consacrées, à partir de l’étude d’un ensemble de sculptures de l’artiste d’origine bahamienne Tavares Strachan utilisant la pietà, dont le Christ et la Madone ont les traits de Malcolm X, de Steve Biko, d’Amadou Diallo et de leur mère respective. Il analyse les modalités d’imitation et de transgression des modèles par le choix des corps et des gestes, et défend que l’artiste se réapproprie les représentations du passé pour proposer des statues mémorielles dans le contexte du mouvement Black Lives Matter et des monuments publics déboulonnés.
A Tradition and Its Metamorphoses (1968–2024): Corporeality in Works by Octavio Paz, Ulises Carrión, And Rocío Cerón
Authors: Brocca Josué Humberto
Published: January 2025

Throughout the twentieth and twenty-first centuries, the Mexican poetic tradition has changed its shape with its incorporation of avant-garde aesthetics and anti-traditional practices, producing a genealogy of texts that circle upon corporeality. This paper presents a diachronic analysis of a selection of works by three Mexican poets who, at different times, have explored this uncertain territory by transposing poetry to alternate media outputs with reflections on these themes: Octavio Paz, Ulises Carrión, and Rocío Cerón.
Intermediate Acts of Incorporation: Body, Psychogeography, and Drift in Arts with Electronic Technologies
Authors: Monreal Ramírez Jesús Fernando
Published: January 2025

In this article, I explore the rupture between the regime of the body as a performative device and the regime of the body defined by what I call an intermediate act of incorporation: an expression to designate acts in which a medium updates its material presence, with its own rules, by transfer with another medium in a way that enables the real capacities of communication and cognition. This process tells us about an ontological and epistemological dimension of intermediality.
Intercorporeal Togetherness: Live Arts and Embodied Poiesis
Authors:   TACo Colectivo, González-Grandón Ximena A. , Suárez Gómez Ainhoa , García De la Torre Mauricio , Castañeda Urzúa Katia , Sotelo Montaño Evoé
Published: January 2025

In the realm of collaborative improvisation, adept performers undergo a profound state of embodied coordination, affective openness, and shared spatiotemporal awareness, engendering a palpable sense of “togetherness.” This phenomenon unfolds through an intensified bodily focus, particularly evident during the transitions from an individual, first-person perspective to a collective one, thereby disrupting the conventional boundaries between self and others. The TACo Collective delves into this intricate aspect of the performing arts, challenging conventional aesthetic and intra-cerebral approaches in favor of a more embodied, sense-based exploration. Our perspective advocates for a heightened emphasis on cultivated bodily awareness, encompassing elements of proprioceptive-kinesthetic understanding, expressive experiences, and affective resonance. This, coupled with dynamic processes such as the deliberate location and transmission of bodily energy, significantly contributes to the cultivation of shared attention and the facilitation of creative reflection. Our ongoing work proposes that the phenomenon of intercorporeal togetherness in the live arts serves as a promising frontier for the intersection of relational and enactive cognitive science. In doing so, it unveils novel insights into nonverbal communication and interbodily intersubjectivity within artistic contexts.
Devised Drama as Social-Emotional Learning
Authors: McGovern Kathleen R. , Yeganeh Vahdat
Published: January 2025

This qualitative case study explores social-emotional learning (SEL) in an extracurricular drama program in the US, where adult English for Speakers of Other Languages (ESOL) students collaboratively devised a play, which they performed publicly. The authors drew from CASEL’s (2020) SEL framework, which consists of five core competencies, to explore drama as an SEL process. The findings indicate that devised drama engaged learners in activities that cultivated awareness of the self and others, created space for students to explore their emotions in a supportive community, and centered learner voices, indicating drama’s potential as an innovative SEL pedagogy within and beyond traditional learning spaces.
Investigating Problems that Matter for Young People: Reauthoring Possibilities for Social-Emotional Learning in English Language Education
Authors: O’Brien Siobhan , Vicars Mark , González Jordan
Published: January 2025

This article reports on a qualitative case study with families of young English as an additional language (EAL) children in year 3–4 classrooms in metropolitan Melbourne, Australia. In the context of this inquiry, developmental bibliotherapy, which uses books to “heal the mind,” was operationalized as a social-emotional learning (SEL) tool, using a transactional reader response approach. In this SEL approach, children made life-to-text and text-to-life connections that focused on three topic areas: body image, resilience, and self-esteem through the reading encounter. Findings shed light on the pedagogical implications of developmental bibliotherapy as an SEL tool and an eudaimonic factor in young EAL children’s life worlds.
I Felt “Safe and Heard”: Nurturing English Majors’ Social-Emotional Skills through the Discussion of Controversial Issues in the Hungarian University Context
Authors: Pereszlényi Anna , Divéki Rita
Published: January 2025

Amidst contemporary challenges (e.g. pandemics, wars), integrating social-emotional learning (SEL) in English as a foreign language (EFL) classes is crucial for fostering students’ growth and emotional well-being. This study aimed to reveal how a language seminar can contribute to nurturing university students’ SEL skills while also developing their language skills by engaging in discussions about controversial issues (CIs). Two groups of students, taught by the two authors, participated in the study. The results reveal that the students appreciated the discussions about CIs, found them challenging but enjoyable, and conducive to developing SEL skills. The results imply that creating an SEL-based syllabus focusing on CI could be both feasible and worthwhile.
Numerical terramechanics simulation and validation of soil volume in wheel loader bucket
Authors:   Bioresource Engineering Department, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada., Boily Guillaume , Adamchuk Viacheslav ,   Bioresource Engineering Department, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada., Roberge Martin ,   Advanced Technology & Innovation Group, Soil and Crop Modeling Team, CNH Industrial Canada Ltd, Saskatoon, Saskatchewan, Canada, Sadrmanesh Vahid ,   Advanced Technology & Innovation Group, Soil and Crop Modeling Team, CNH Industrial Canada Ltd, Saskatoon, Saskatchewan, Canada
Published: January 2025

This research, which focuses on validating the simulated soil volume in two distinct wheel loader buckets, relies heavily on field tests to validate the simulation method. The study compared validation iterations to volume data from corresponding field tests performed on a standardized soil pile. The soil particle properties were determined by specific soil characterization tests, which were then meticulously virtually replicated to calibrate the simulation materials accurately. The study compared the simulated and actual soil volumes in the wheel loader buckets using Discrete-Element Method (DEM), Light Detection and Ranging (LiDAR), and real-time simulation. The weight-based method data extracted from the field tests were used as a benchmark for the methodology comparison. The study found that bucket B at speed one (low speed) had a significantly larger capacity than the other bucket and speed combinations, as demonstrated by the results of the weigh-based method. The LiDAR methodology presented excellent volume prediction capacity, with some sectionalization in the results due to the field methodology. The study validated the precision simulation capacity to simulate the volume of soil in the wheel loader buckets by constant simulation results in between the value limits of the benchmark results. The accuracy assessment of the real-time simulation method was agreeably surprising, with results constantly near the precision simulation. The study also describes the methodologies for wheel loader field tests, measurements of physical test material, virtual material calibration using DEM, real-time simulation, statistical comparison between estimation methodologies, and results explanation.
Autologous P63+ lung progenitor cell transplantation in idiopathic pulmonary fibrosis: a phase 1 clinical trial
Authors: Zhang Shiyu , Zhou Min , Shao Chi , Zhao Yu , Liu Mingzhe , Ni Lei , Bao Zhiyao , Zhang Qiurui , Zhang Ting , Luo Qun , Qu Jieming , Xu Zuojun , Zuo Wei
Published: January 2025

In idiopathic pulmonary fibrosis (IPF) patients, alveolar epithelium architectures are persistently lost and lung gas transfer function would decline over time, which cannot be rescued by conventional anti-fibrotic therapy. P63+ airway basal progenitor cells are previously reported to have great potential to repair damaged lung epithelium. Here, we successfully cloned and expanded the autologous P63+ progenitor cells from IPF patients to manufacture the cell therapeutic product REGEND001, which were further characterized by cell morphology and single-cell transcriptomic analysis. Subsequently, an open-label, dose-escalation autologous progenitor cell transplantation clinical trial (CTR20210349) was conducted. The primary outcome was the incidence and severity of the cell therapy-related adverse events (AEs); secondary outcome included other safety and efficacy evaluation in each dose groups. We treated 12 patients with ascending doses of cells: 0.6x, 1x, 2x and 3.3× 10
6
cells/kg bodyweight. The data revealed that P63+ basal progenitor cell was safe and well tolerated at all doses, with no dose-limiting toxicity or cell therapy-related severe adverse events observed. Patients in the three higher dose groups showed statistically significant improvement of lung gas transfer function as well as exercise ability after REGEND001 therapy. Resolution of honeycomb lesion was also observed in patients of higher dose groups. Altogether these results indicated that REGEND001 has high safety profile and meanwhile encourages further efficacy exploration in IPF patients.
Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions
Authors: Zhu Lingqin , Yang Lang , Men Fangli , Yu Jianwei , Sun Shuyang , Li Chenguang , Ma Xianzong , Xu Junfeng , Li Yangjie , Tian Ju , Wang Xin , Xie Hui , Kang Qian , Duan Linghui , Yi Xiang , Guo Wei , Gong Xueqing , Guo Ni , Lu Youyong , Leung Joseph , He Yuqi , Sheng Jianqiu
Published: January 2025

The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers that serve simultaneously for early diagnosis and prognostic prediction in CRC patients. Herein, we developed a plasma panel (27 DMRs, differential methylated regions) and validated its superior performance across CRC diagnosis and prognosis prediction in an independent cohort. We first conducted a preliminary screening of 119 CRC tissue samples to identify CRC-specific methylation features. Subsequently, a CRC-specific methylation panel was developed by further filtering 161 plasma samples. Then machine learning algorithms were applied to develop diagnosis and prognosis models using cfDNA samples from 51 CRC patients and 33 normal controls. The diagnosis model was tested in a cohort consisting of 30 CRC, 37 advanced adenoma (AA), and 14 healthy plasma samples, independently validated in a cohort consisting of 18 CRC, 91 NAA, 23 AA and 34 healthy plasma samples. In the tissue external validation cohort (GSE48684), the cfDNA methylation diagnosis model conducted with the panel, have the area under the curve (AUC) reached 0.983, and for the plasma cfDNA model in the external validation cohort, the sensitivities for NAA, AA and CRC 0 -Ⅱ are 48.4%. 52.2% and 66.7% respectively, with a specificity of 88%. Additionally, the panel was applied to patient staging and metastasis, performing well in predicting CRC distant metastasis (AUC = 0.955) and prognosis (AUC = 0.867). Using normal samples as control, the changes in methylation score in both tissue and plasma were consistent across different lesions, although the degree of alterations varied with severity. The methylation scores vary between paired tissue and blood samples, suggesting distinct mechanisms of migration from tumor tissue to blood for the 27 DMRs. Together, Our cfDNA methylation models based on 27 DMRs can identify different stages of CRC and predict metastasis and prognosis, ultimately enabling early intervention and risk stratification for CRC patients.
Assessment of Combining Ability for Seed Yield Per Plant and Its Component Characteristics in Castor (Ricinus communis L.)
Authors: Pandor B. L. , Patel M. P. , Chaudhari R. H. , Yadav Indra Raj
Published: January 2025

Combining ability for seed yield and its component traits in castor was studied using line × tester mating design involving three diverse pistillate lines and fourteen inbred lines. Analysis of variance revealed that, The estimates of σ2gca were higher than the corresponding σ2sca for plant height upto primary raceme, effective number of spikes per plant, seed yield per plant, 100 seed weight and oil content, indicated that the preponderance of additive component of genetic variance for these traits, while for the remaining traits, non-additive component of genetic variance was predominant. Two parental lines, SKP 84 and Geeta among the females and ANDCI 14, ANDCI 8, ANDCI 12-2, SKI 343 and DCS 109 among the males, exhibited good general combining ability effects for seed yield per plant and at least for two to three important yield contributing attributes. The best hybrids, SKP 84 × ANDCI 14, SKP 84 × ANDCI 10-3 and Geeta × SKI-343 registered high heterobeltiosis, standard heterosis and desirable highest sca effects for seed yield alongwith high per se performance may be directly exposed for commercial cultivation and may be advanced for development of parental genotypes by incorporating all the desirable characters in parental genotypes, which showed their superiority for seed yield and yield attributing characters.
Assessment of Knowledge, Attitude and Practice Regarding Cardiovascular Disease Prevention among Young Adults in South India: A Cross Sectional Study
Authors: Joseph Josina , Dharan Shaiju S
Published: January 2025

Background: In the era of unhealthy diet and sedentary lifestyle, Cardiovascular Disease (CVD) is one of the major health care concern all over the world. Assessing the knowledge, attitude and practice regarding cardiovascular disease prevention among the youth adults reveals the requirement of preventive measures to build up a healthy individual in the future.
Methods: Cross- sectional survey involving 130 study subjects. It was conducted through self-structured questionnaire among young adults of age group 18-25 years.
Results: The association between CVD prevention practice and knowledge level was not statistically significant (χ² = 5.90, p = 0.207). A highly significant association was found between attitude and knowledge levels (χ² = 32.54, p < 0.001). The relationship between attitude and practice was not statistically significant (χ² = 0.08, p = 0.96). Both positive and negative attitude groups showed nearly identical practice distributions, suggesting that attitude alone might not strongly influence actual preventive practices.
Conclusion: To combat the alarming rise of CVD in young Indians, we must translate scientific knowledge into actionable health practices tailored to their specific needs.
Response of Varying Seedling Age, Transplanting Time and Foliar Supplements on Growth and Biomass of Rice
Authors: Singh Shubham , Verma Omvati , Chandra Subhash , Bhatnagar Amit , Gautam Poonam , Guru S.K.
Published: January 2025

In India rice is mostly grown through transplanting method. Sometimes, transplanting is delayed due to late onset of the monsoon, lack of irrigation facility and labour scarcity which ultimately affect physiological growth and yield of rice crop. For managing this situation foliar spray at vegetative and reproductive stage may be an option to increase plant growth and productivity. Therefore, an experiment was planned during Kharif season 2022 and 2023 at N.E. Bourlag Crop Research Centre of G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand to find out response of seedling age, transplanting time and foliar nutrition on dry matter accumulation, plant height, crop growth rate and relative growth rate of rice. The experiment was laid out in split plot design with three replications. The experiment consisted of five treatments in main plot viz., N1: 25 days nursery transplanting on 25 June, N2: 25 days nursery transplanting on 2 July, N3: 32 days nursery transplanting 2 July, N4: 25 days nursery transplanting on  9 July and N5: 39 days nursery transplanting on 9 July and three foliar treatments in sub plot  F0:control, F1: foliar spray of urea 2 % at active tillering stage followed by spray of  MOP 1%  at panicle emergence stage  and F2: foliar spray of  NPK 2 % at active tillering followed by spray of  KNO3 1% at panicle emergence stage. Results of present study revealed that varying seedling age and transplanting time significantly influenced plant height, dry matter accumulation, CGR and RGR of rice. The maximum dry matter accumulation and growth was recorded in 25 days nursery transplanting 25 June(N1) treatment which was at par with 25 days nursery transplanting on 2 July(N2). The reduction in dry matter and growth was recorded with 39 days nursery transplanting on 9 July(N5) and 25 days nursery transplanting on 9 July (N4) treatments. Among foliar treatments, foliar supplements significantly improved growth parameters of rice as compared to control.
The Problematic Legacy of Skin-Thickness Measurement in Race-Based Dermatology Research
Authors: Sadeghi Nakisa B. , Adamson Adewole S.
Published: December 2023

This Viewpoint presents an opportunity for dermatologists to think critically about how race has affected skin research.
Past-Year Use Prevalence of Cannabidiol, Cannabigerol, Cannabinol, and Δ8-Tetrahydrocannabinol Among US Adults
Authors: Wilson-Poe Adrianne R. , Smith Tristin , Elliott Michael R. , Kruger Daniel J. , Boehnke Kevin F.
Published: December 2023

This survey study characterizes past-year use prevalence and factors associated with use of cannabidiol, cannabigerol, cannabinol, and Δ8-tetrahydrocannabinol among US adults.
Association of COVID-19 Intensity With Burnout and Perceptions of Residency Preparedness Among Medical Students
Authors: Dyrbye Liselotte N. , Brushaber Danielle , West Colin P.
Published: December 2023

This cross-sectional study of US medical students assesses the association of COVID-19 intensity in the clinical learning environment with student burnout and perceptions regarding residency preparedness.
Online accelerated data‐driven learning for optimal feedback control of discrete‐time partially uncertain systems
Authors: Somers Luke , Haddad Wassim M. , Kokolakis Nick‐Marios T. , Vamvoudakis Kyriakos G.
Published: December 2023

In this paper, we develop an online learning algorithm for solving the Bellman equation for affine in the control discrete‐time nonlinear uncertain dynamical systems. To ensure accelerated learning of our algorithm in generating optimal control policies, we use an actor‐critic structure predicated on higher‐order tuner laws. More specifically, we construct a Nesterov‐like architecture involving momentum‐based learning laws leading to an accelerated convergence of the optimal control policy. The proposed online learning‐based optimal control framework guarantees uniform ultimate boundedness of the closed‐loop system under the assumption that the system is persistently excited. Finally, two illustrative numerical examples are provided to demonstrate the efficacy of the proposed approach.
Characterization of Common Minke Whale (Balaenoptera Acutorostrata) Cell Lines Immortalized with the Expression of Cell Cycle Regulators
Authors: Sekine Aya , Yasunaga Genta , Kumamoto Soichiro , Fujibayashi So , Munirah Izzah , Bai Lanlan , Tani Tetsuya , Sugano Eriko , Tomita Hiroshi , Ozaki Taku , Kiyono Tohru , Inoue‐Murayama Miho , Fukuda Tomokazu
Published: December 2023

Primary cultured cells cannot proliferate infinite. The overcoming of this limit can be classified as immortalization. Bypass of p16 senescence protein induces efficient immortalization various types of mammalians is previously reported. However, the Cetacea species is not known. Here, that common minke whale‐derived cells can be immortalized with a combination of human genes, mutant cyclin‐dependent kinase 4 (CDK4R24C), cyclin D1, and Telomerase Reverse Transcriptase (TERT) is reported. These results indicate that the function of cell cycle regulators in premature senescence is evolutionarily conserved. This study describes the conserved roles of cell cycle regulators in the immortalization of cells from humans to Cetacea species. Furthermore, using RNA‐seq based on next‐generation sequencing, the gene expression profiles of immortalized cells are compared with parental cells as well as those immortalized with SV40 large T antigen, which is once a popular method for cellular immortalization. The profiling results show that newly established common minke‐whale‐derived immortaliozed cells have completely different profiles from SV40 cells. This result indicates that the expression of mutant CDK4, cyclin D1, and TERT enables to establish immortalized cell lines with different biological nature from SV40 expressing cells.
Multiple H‐Bonding Cross‐Linked Supramolecular Solid–Solid Phase Change Materials for Thermal Energy Storage and Management
Authors: Wang Chenyang , Geng Xin , Chen Jing , Wang Hailong , Wei Zhengkai , Huang Bingxuan , Liu Wei , Wu Xiaodong , Hu Linyu , Su Gehong , Lei Jingxin , Liu Zhimeng , He Xin
Published: December 2023

Solid–solid phase change materials (SSPCMs) are considered among the most promising candidates for thermal energy storage and management. However, the application of SSPCMs is consistently hindered by the canonical trade‐off between high TES capacity and mechanical robustness. In addition, they suffer from poor recyclability due to chemical cross‐linking. Herein, a straightforward but effective strategy for fabricating supramolecular SSPCMs with high latent heat and mechanical strength is proposed. The supramolecular polymer employs multiple H‐bonding interactions as robust physical cross‐links. This enables SSPCM with a high enthalpy of phase transition (142.5 J g−1), strong mechanical strength (36.9 MPa), and sound shape stability (maintaining shape integrity at 120 °C) even with a high content of phase change component (97 wt%). When SSPCM is utilized to regulate the operating temperature of lithium‐ion batteries, it significantly diminishes the battery working temperature by 23 °C at a discharge rate of 3 C. The robust thermal management capability enabled through solid–solid phase change provides practical opportunities for applications in fast discharging and high‐power batteries. Overall, this study presents a feasible strategy for designing linear SSPCMs with high latent heat and exceptional mechanical strength for thermal management.
Eco‐Friendly Solvent Engineered CsPbI2.77Br0.23 Ink for Large‐Area and Scalable High Performance Perovskite Solar Cells
Authors: Abate Seid Yimer , Qi Yifang , Zhang Qiqi , Jha Surabhi , Zhang Haixin , Ma Guorong , Gu Xiaodan , Wang Kun , Patton Derek , Dai Qilin
Published: December 2023

The performance of large‐area perovskite solar cells (PSCs) has been assessed for typical compositions, such as methylammonium lead iodide (MAPbI3), using a blade coater, slot‐die coater, solution shearing, ink‐jet printing, and thermal evaporation. However, the fabrication of large‐area all‐inorganic perovskite films is not well developed. This study develops, for the first time, an eco‐friendly solvent engineered all‐inorganic perovskite ink of dimethyl sulfoxide (DMSO) as a main solvent with the addition of acetonitrile (ACN), 2‐methoxyethanol (2‐ME), or a mixture of ACN and 2‐ME to fabricate large‐area CsPbI2.77Br0.23 films with slot‐die coater at low temperatures (40–50 °C). The perovskite phase, morphology, defect density, and optoelectrical properties of prepared with different solvent ratios are thoroughly examined and they are correlated with their respective colloidal size distribution and solar cell performance. The optimized slot‐die‐coated CsPbI2.77Br0.23 perovskite film, which is prepared from the eco‐friendly binary solvents dimethyl sulfoxide:acetonitrile (0.8:0.2 v/v), demonstrates an impressive power conversion efficiency (PCE) of 19.05%. Moreover, the device maintains ≈91% of its original PCE after 1 month at 20% relative humidity in the dark. It is believed that this study will accelerate the reliable manufacturing of perovskite devices.
Unconventional Synthesis of Hierarchically Twinned Copper as Efficient Electrocatalyst for Nitrate–Ammonia Conversion
Authors: Hu Qi , Huo Qihua , Qi Shuai , Deng Xin , Zhuang Jiapeng , Yu Jiaying , Li Xuan , Zhou Weiliang , Lv Miaoyuan , Chen Xinbao , Wang Xiaodeng , Feng Chao , Yang Hengpan , He Chuanxin
Published: December 2023

Twin boundary (TB) engineering provides exciting opportunities to tune the performance levels of metal‐based electrocatalysts. However, the controllable construction of TB greatly relies on surfactants, blocking active sites, and electron transfer by surfactants. Here, a surfactant‐free and facile strategy is proposed for synthesizing copper (Cu) nanocatalysts with dense hierarchical TB networks (HTBs) by the rapid thermal reductions in metastable CuO nanosheets in H2. As revealed by in situ transmission electron microscopy, the formation of HTBs is associated with the fragmentation of nanosheets in different directions to generate abundant crystal nuclei and subsequently unconventional crystal growth through the collision and coalescence of nuclei. Impressively, the HTBs endow Cu with excellent electrocatalytic performance for direct nitrate–ammonia conversion, superior to that of Cu with a single‐oriented TB and without TB. It is discovered that the HTBs induce the formation of compressive strains, thereby creating a synergistic effect of TBs and strains to efficiently tune the binding energies of Cu with nitrogen intermediates (i.e., NO2*) and thus promote the tandem reaction process of NO3−‐to‐NO2− and subsequent NO2−‐to‐NH3 electrocatalysis. This work demonstrates the crucial role of HTBs for boosting electrocatalysis via the synergistic effect of TBs and strains.
Building Conventional Metasurfaces with Unconventional Interband Plasmonics: A Versatile Route for Sustainable Structural Color Generation Based on Bismuth
Authors: Chacon‐Sanchez Fernando , de Galarreta Carlota Ruiz , Nieto‐Pinero Eva , Garcia‐Pardo Marina , Garcia‐Tabares Elisa , Ramos Nicolas , Castillo Miguel , Lopez‐Garcia Martin , Siegel Jan , Toudert Johann , Wright C. David , Serna Rosalia
Published: December 2023

Plasmonic metasurfaces for structural color generation are typically built using the archetypal noble metals, gold, and silver. These possess plasmonic properties in the visible spectrum due to their inherent high free carrier densities. However, they are much more expensive compared to many other metals and exhibit several nanofabrication issues such as bad surface adhesion or thermally activated inter‐diffusion. In this work, it is shown that interband plasmonic materials –whose optical properties are driven by interband transitions instead of free carriers— are appealing candidates for the fabrication of sustainable and cost‐efficient metasurfaces for structural coloring. By using bismuth, an environment‐friendly interband plasmonic material cheaper than gold and silver, nanodisks gap‐plasmon metasurfaces and planar Fabry‐Perot cavities are modeled and fabricated, which both successfully enable pure colors that can be robustly tailored upon suitable design. By direct experimental comparison between both types of design in terms of color efficiency, fabrication complexity, and angular robustness; how bismuth‐based gap surface plasmon metasurfaces can be excellent candidates for color microprinting is shown, whereas nanolayered Bi Fabry‐Pérot cavities are ideal for macroscopic color coatings due to their ease of fabrication and implementation.