bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Synthesis of Dibenzo(d,f)‐1,2‐selena and ‐1,2‐thiazepin‐3‐ones Derivatives, Bis‐Homoebselen.
Authors: MOHSINE A. , CHRISTIAENS L.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Mono‐, Di‐, Tri‐, and Tetraethyl‐o‐carboranes by Electrophilic Alkylation of o‐Carborane with Ethyl Bromide in the Presence of AlCl3 and Their Transformations
Authors: ZAKHARKIN L. I. , OL'SHEVSKAYA V. A. , VORONTSOV E. V. , PETROVSKII P. V.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Addition of Phosphorus‐Stabilized Carbanions to Cyclic Enones and Further Transformations of the Reaction Products.
Authors: PIENAAR A. , MODRO T. A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Acylphosphonamidates and α‐Hydroxyiminophosphonamidates. Synthesis of N‐Acylphosphordiamidates by Beckmann Rearrangement. Crystal Structure of (E)‐α‐Hydroxyiminobenzyl‐1‐ pyrrolidinylphosphinate.
Authors: BREUER E. , ZAHER H. , TASHMA Z. , GIBSON D.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of P(MeNCH2CH2)3N with Primary, Secondary, and Tertiary Alkyl Halides: Evidence for a Solvent‐Enhanced Dehydrohalogenation.
Authors: MOHAN T. , ARUMUGAM S. , WANG T. , JACOBSON R. A. , VERKADE J. G.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Behavior of 1,1‐Diphenyl‐2,5‐dihydrophospholium Salts Toward Bases: Ylide Formation or Ring Opening.
Authors: CRISTAU H.‐J. , GRENIER J. , LEZOURET P. , TORREILLES E.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Hydrostannylations of 1‐Bromoalkynes. A Practical Synthesis of (E)‐1‐Stannylalk‐1‐enes.
Authors: BODEN C. D. J. , PATTENDEN G. , YE T.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Marine Natural Products. Part 37. Aragusteroketals A and C, Two Novel Cytotoxic Steroids from a Marine Sponge of Xestospongia sp.
Authors: KOBAYASHI M. , CHEN Y.‐J. , HIGUCHI K. , AOKI S. , KITAGAWA I.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of 20‐(Hydrofuryl)steroids via Isoxazole Derivatives.
Authors: KHRIPACH V. A. , ZHABINSKII V. N. , OL'KHOVIK V. K. , ZAVADSKAYA M. I. , DRACHENOVA O. A. , KHRIPACH N. B.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3α‐Hydroxy‐3β‐(phenylethynyl)‐5β‐pregnan‐20‐ones: Synthesis and Pharmacological Activity of Neuroactive Steroids with High Affinity for GABAA Receptors.
Authors: UPASANI R. B. , YANG K. C. , ACOSTA‐BURRUEL M. , KONKOY C. S. , MCLELLAN J. A. , WOODWARD R. M. , LAN N. C. , CARTER R. B. , HAWKINSON J. E.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Expeditious Synthesis of (2R,3S)‐3‐tert‐Butoxycarbonylamino‐1‐ isobutylamino‐4‐phenyl‐2‐butanol, a Key Building Block of HIV Protease Inhibitors.
Authors: SHIBATA N. , KATOH T. , TERASHIMA S.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structures of (.+‐.)‐1,4‐Di‐O‐benzoyl‐2,3‐O‐isopropylidene‐myo‐ inositol and (.+‐.)‐1,4‐Di‐O‐benzoyl‐5,6‐O‐isopropylidene‐myo‐inositol: A Conformational Analysis.
Authors: CHUNG S.‐K. , CHANG Y.‐T. , WHANG D. , KIM K.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Conversion of p‐Methoxyphenyl Glycosides into the Corresponding Glycosyl Chlorides and Bromides, and into Thiophenyl Glycosides.
Authors: ZHANG Z. , MAGNUSSON G.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 2‐(β‐D‐Glycopyranosyl)nitroethenes and ‐nitroethanes via Aldehydo Derivatives.
Authors: PETRUSOVA M. , BEMILLER J. N. , KRIHOVA A. , PETRUS L.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Chemical Synthesis of a 3‐Deoxy‐D‐arabino‐heptulosonic Acid 7‐ Phosphate (DAHP) Derivative (XIII) and Its 2‐Deoxy Analogue
Authors: MLYNARSKI J. , BANASZEK A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of Bioactive Functions in Hydrangeae Dulcis Folium. Part 6. Syntheses of Thunberginols A and F and Their 3′‐Deoxy‐Derivatives Using Regiospecific Lactonization of Stilbene Carboxylic Acid: Structures and Inhibitory Activity on Histamine Release of Hydramacrophyllols A and B.
Authors: YOSHIKAWA M. , SHIMADA H. , YAGI N. , MURAKAMI N. , SHIMODA H. , YAMAHARA J. , MATSUDA H.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies in Macrolide Synthesis: A Novel Cyclodimerization Approach to the Synthesis of Elaiophylin Using a Double Stille Cross‐Coupling Reaction.
Authors: PATERSON I. , MAN J.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient and Selective Synthesis of Nakienone A Involving a Novel Protocol for α‐Alkenylation of Ketones via Palladium‐Catalyzed Alkenyl‐Alkenyl Coupling.
Authors: POUR M. , NEGISHI E.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Titanium, Zirconium, and Hafnium
Authors: COTTON S. A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxygen, Sulfur, Selenium, and Tellurium
Authors: KELLY P. F.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transition‐Metal Sulfur Chemistry: Biological and Industrial Significance and Key Trends
Authors: STIEFEL E. I.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: No‐Donors: An Emerging Class of Compounds in Medicinal Chemistry
Authors: GASCO A. , FRUTTERO R. , SORBA G.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Environmentally Friendly Catalytic Methods
Authors: CLARK J. H. , MACQUARRIE D. J.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Potential Energy Surface Crossings in Organic Photochemistry
Authors: BERNARDI F. , OLIVUCCI M. , ROBB M. A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Invited Review. The Chemistry of Biology: Molecular Evolution, the Total Synthesis of Proteins, and DNA Restriction and Modification
Authors: LAMBERT J. N.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Specificity and Versatility in Erythromycin Biosynthesis
Authors: PIEPER R. , KAO C. , KHOSLA C. , LUO G. , CANE D. E.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Non‐Porphyrin Photosensitizers in Biomedicine
Authors: WAINWRIGHT M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Application of Mass Spectrometry for Characterizing and Identifying Ligands from Combinatorial Libraries
Authors: LOO J. A. , DEJOHN D. E. , OGORZALEK LOO R. R. , ANDREWS P. C.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Excursions into Long‐Lived Vinyl Cations: NMR Spectroscopic Characterization of α‐Aryl Vinyl Cations
Authors: SIEHL H.‐U.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Mixed Nickel—Lithium Pyrophosphate, LiNi1.5P2O7.
Authors: RISSOULI K. , BENKHOUJA K. , SADEL A. , BETTACH M. , ZAHIR M. , GIORGI M. , PIERROT M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Substituent Effects on the Gas‐Phase Basicities of 4‐X‐Acetophenones and 4‐X‐2,6‐Dimethylacetophenones: A Comparison with Solution Basicities.
Authors: DELL'ERBA C. , MUGNOLI A. , NOTO R. , NOVI M. , OCCHIUCCI G. , PETRILLO G. , SANCASSAN F. , SPINELLI D.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Long‐Distance Effect on One‐Bond C‐C Scalar Couplings Upon Introduction of a Double Bond in Bicyclic Systems.
Authors: JONES G. R. , CALDARELLI S. , VOGEL P.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ruthenium‐Catalyzed Ring Closing Olefin Metathesis of Non‐Natural . alpha.‐Amino Acids.
Authors: RUTJES F. P. J. T. , SCHOEMAKER H. E.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Regeneration of Carbonyl Compounds from Oximes and Tosylhydrazones with TBHP.
Authors: BARHATE N. B. , GAJARE A. S. , WAKHARKAR R. D. , SUDALAI A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transformation of Ketones and Aldehydes to gem‐Dihalides via Hydrazones Using Copper(II) Halides.
Authors: TAKEDA T. , SASAKI R. , YAMAUCHI S. , FUJIWARA T.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Organomanganese(II) Complexes Active as Homogeneous Catalysts in Manganese(II)/Copper(I)‐Catalyzed Carbon‐Carbon Bond Formation Reactions.
Authors: DONKERVOORT J. G. , VICARIO J. L. , JASTRZEBSKI J. T. B. H. , CAHIEZ G. , VAN KOTEN G.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Mild and Efficient Method for the Selective Cleavage of tert‐ Butyldimethylsilyl Ethers to Alcohols.
Authors: MAITI G. , ROY S. C.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Imino‐Wittig Rearrangement of Benzyl and Allyl Hydroximates.
Authors: MIYATA O. , KOIZUMI T. , NINOMIYA I. , NAITO T.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of 4‐Aryl‐3‐thiosemicarbazides with Carbon Disulfide: A Facile Synthesis of 2,3‐Dihydrothiazoles (III) and Their Fused Derivatives.
Authors: MOHAREB R. M. , SHERIF S. M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoinduced Processes in 2‐(2‐Hydroxyaryl)pyridine Molecules. Part 1. Synthesis, Structure, and Physico‐Chemical Properties of 2‐(2‐ Hydroxyaryl)‐4,6‐diarylpyridines
Authors: OLEKHNOVICH E. P. , KOROBKA I. V. , BORODKIN G. S. , MAKAROVA N. I. , KNYAZHANSKII M. I.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Access to 2,4‐Substituted Quinolines from Acetylenic Ketones.
Authors: MASQUELIN T. , OBRECHT D.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Utilization of the Intramolecular Cycloaddition‐Cationic π‐ Cyclization of an Isomuenchnone Derivative for the Synthesis of (.+‐.)‐ Lycopodine.
Authors: PADWA A. , BRODNEY M. A. , MARINO J. P. JUN. , SHEEHAN S. M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Simple High‐Yielding Synthesis of Ferrocene‐1,1′‐diylbis‐( methyltrimethylammonium iodide) (V).
Authors: GLIDEWELL C. , ROYLES B. J. L. , SMITH D. M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Functional Moiety for the Antifungal Activity of Phytocassane E, a Diterpene Phytoalexin from Rice.
Authors: KOGA J. , OGAWA N. , YAMAUCHI T. , KIKUCHI M. , OGASAWARA N. , SHIMURA M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Peptide Derivatives of Mimosine. Part 1. L‐Mimosylglycine.
Authors: ROBLOT G. , FEHRENTZ J.‐A. , WYLDE R. , MARTINEZ J.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Acosamine and Daunosamine from Sugar δ‐Enelactones.
Authors: SOCHA D. , JURCZAK M. , CHMIELEWSKI M.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Use of the Wolff Rearrangement of Diazo Ketones from Amino Acids as a Synthetic Method for the Formation of Oligonucleo‐Peptides: A Novel Approach to Chimeric Biomolecules.
Authors: GUIBOURDENCHE C. , SEEBACH D. , NATT F.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Glutarimide Antibiotics Analogues Having a Conjugated Enaminodiketone Fragment.
Authors: BURAVSKAYA T. N. , LAKHVICH F. A.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Useful Synthesis of 2,3,6‐Polythiazole‐Substituted Pyridine Skeleton ( Fragment A‐C) of Peptide Antibiotic Micrococcin P.
Authors: OKUMURA K. , SHIGEKUNI M. , NAKAMURA Y. , SHIN C.
Published: August 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Derivatization of fatty alcohol ethoxylate non‐ionic surfactants using 2‐sulfobenzoic anhydride for characterization by liquid chromatography/mass spectrometry
Authors: Zu Chengli , Praay Herbert N. , Bell Bruce M. , Redwine O. David
Published: August 2010

A derivatization procedure has been developed for the improved characterization of fatty alcohol ethoxylate non‐ionic surfactants by liquid chromatography/mass spectrometry. The end hydroxyl group of each surfactant species was converted into an oxycarbonylbenzene‐2‐sulfonic acid group with 2‐sulfobenzoic anhydride under mild conditions. The produced sulfonic acid group allows all species, including fatty alcohols and those with less than three ethoxylates, to be uniformly ionized by electrospray ionization (ESI) mass spectrometry. Both acid and base can be used as a mobile phase additive for liquid chromatography without affecting Mn and average ethoxylate values, although ion intensities are suppressed during the ESI process. The method was used to analyze seven commercial fatty alcohol ethoxylate non‐ionic surfactants, and the determined Mn and EO values were comparable with the results obtained by NMR. The relative ratio of different fatty alcohol based ethoxylates in a sample can also be determined using the summed mass spectral data. Copyright © 2009 The Dow Chemical Company
Effectiveness of a Surgical Glove Port for Single Port Surgery
Authors: Hayashi Michihiro , Asakuma Mitsuhiro , Komeda Koji , Miyamoto Yoshiharu , Hirokawa Fumitoshi , Tanigawa Nobuhiko
Published: August 2010

Background

A new surgical concept, such as single port surgery (SPS), usually raises many questions regarding safety, usefulness, appropriateness, applicability, and cost. Because many new port devices have been developed, choosing the type of port device for SPS is the most important factor. We herein briefly report our newly developed SPS port made using a standard surgical glove.

Methods

SPS starts with a 1.5‐cm skin incision on the umbilicus. Subsequently, a wound retractor of XS size is installed at the umbilical wound. Then, a non‐powdered surgical glove (5.5 inches) is put on the wound retractor through which three 5‐mm slim trocars are inserted via the finger tips. A semi‐flexible laparoscopic camera is inserted via the middle finger port. From June to December 2009, 23 cases of SPS (20 cholecystectomies, 1 choledocholithotomy, 1 appendectomy, and 1 gastropexy) were performed in our institute using this technique.

Results

All cases were successfully performed without any intra‐ or postoperative complications. No conversion to other procedures was needed. The median operative time for cholecystectomy was 110 (range, 55–170) min.

Conclusions

This surgical‐glove port is easy to install and is made from conventional, commonly used surgical equipment, making it unnecessary to purchase any expensive new devices. This surgical‐glove port technique is a promising method to introduce SPS, because developing or purchasing new devices is unnecessary. Our experience demonstrates the efficacy, appropriateness, and cost‐effectiveness of this simple port technique.
Abdominal Resection Rectopexy with an Absorbable Polyglactin Mesh: Prospective Evaluation of Morphological and Functional Changes with Consecutive Improvement of Patient’s Symptoms
Authors: Otto S. D. , Ritz J. P. , Gröne J. , Buhr H. J. , Kroesen A. J.
Published: August 2010

Background

The pathophysiology of rectal prolapse and intussusception has not yet been clarified. This is reflected in the multiplicity of surgical procedures. The aim of this prospective study was to measure morphological and functional changes of the pelvic floor and the rectum before and after resection rectopexy.

Methods

A total of 21 patients (mean age 60 years; 2 men, 19 women) with manifest rectal prolapse and rectoanal intussusception underwent sigmoidectomy and rectopexy with an absorbable polyglactin mesh graft. The following analyses were performed preoperatively and, on average, 15 months (range 6–21 month) postoperatively: radiologic defecography, rectal volumetry, sphincter manometry, and evaluation of clinical symptoms.

Results

Postoperatively there was no patient with rectal prolapse, and only one with an intussusception. Rectal compliance increased from 6.4 to 10.2 ml/mmHg. Rectal volumetry showed a decrease of the thresholds for the sensation of “desire to defecate” and “maximal tolerated volume” (100–75 ml, 175–150 ml). Postoperatively, there was a higher level of the pelvic floor during contraction. The anorectal angle, vector volume, radial asymmetry, sphincter length, and resting and squeezing pressures were unchanged. Surgery improved rectal evacuation (p = 0.03), continence (p = 0.01), stool consistency (p = 0.03), and warning period (p = 0.01). Patients’ personal assessment showed an improved overall satisfaction.

Conclusions

Resection rectopexy is a reliable method for treating rectal prolapse and rectoanal intussusception with clear improvement of the patient’s clinical symptoms. The restored anorectal function can be attributed to improved rectal compliance, a lower sensory threshold, an elevation of the pelvic floor during squeezing, and an improved rectal evacuation.
Resident Workload, Pager Communications, and Quality of Care
Authors: Patel Shaun P. , Lee Jay S. , Ranney David N. , Al‐Holou Shaza N. , Frost Christopher M. , Harris Meredith E. , Lewin Sarah A. , Liu Erqi , Madenci Arin , Majkrzak Allen A. , Nelson Jessica , Peterson Sarah F. , Serecky Kerri A. , Wilkinson David A. , Wojcik Brandon M. , Englesbe Michael J. , Lynch Raymond J.
Published: August 2010

With the recent regulations limiting resident work hours, it has become more important to understand how residents spend their time. The volume and content of the pages they receive provide a valuable source of information that give insight into their workload and help identify inefficiencies in hospital communication. We hypothesized that above a certain workload threshold, paging data would suggest breakdowns in communication and implications for quality of care. All pages sent to six general surgery interns at the University of Michigan over the course of one academic year (7/1/2008–6/30/2009) were retrospectively categorized by sender type, message type, message modifier, and message quality. Census, discharge, and admission information for each intern service were also collected, and intern duties were further analyzed with respect to schedule. “On‐call” days were defined as days on which the intern bore responsibility for care of all admitted floor patients. The interns received a total of 9,843 pages during the study period. During on‐call shifts, each intern was paged an average of 57 ± 3 times, and those on non‐call shifts received an average of 12 ± 3 pages. Floor/intensive care unit (ICU) nurses represented 32% of the page volume received by interns. Interestingly, as patient volume increased, there was a decrease in the number of pages received per patient. By contrast, at higher patient volumes, there was a trend toward an increasing percentage of urgent pages per patient. At high intern workloads, our data suggest no major communication breakdowns but reveal the potential for inferior quality of care.
Foley Catheter Enterostomy for Postoperative Bowel Perforation: An Effective Source Control
Authors: Tøttrup Anders
Published: August 2010

Background

Control of bowel effluents is imperative in cases of postoperative bowel perforation, and this is best achieved by stoma formation. When stoma formation is impossible, the surgeon is often left with less optimal choices. We have used a Foley catheter enterostomy to provide source control in difficult cases of bowel perforation, and the details are reviewed in this report.

Methods

Three patients underwent reoperation for postoperative bowel perforation. Two patients had leaking ileocolic anastomoses, and one patient had a leak from a serosal tear. In all cases a Foley catheter enterostomy was constructed at the point of the leak. The balloon was filled with 3 ml of saline, and the affected bowel segment was fixed to the inside of the abdominal wall by a purse‐string suture supplied with a few additional stitches. Moreover, gentle traction was applied to the balloon by external suture fixation of the catheter.

Results

Immediate control of bowel effluents from the leak was achieved in all cases. Early enteral feeding was possible in two of the three patients, and the catheter was removed after 17–28 days. Drainage of bowel contents from the catheter wounds stopped within 2 days.

Conclusions

This report demonstrates an effective and safe technique for sealing a postoperative bowel perforation with a Foley catheter enterostomy. It is useful in cases where a stoma cannot be brought out. The technique provides immediate source control and enables early enteral feeding. The utility of the procedure may be limited when the defect is large, when the surrounding bowel wall lacks integrity, and when it is not possible to mobilize the affected bowel segment toward the inside of the abdominal wall without tension.
Size of the Tumor and Pheochromocytoma of the Adrenal Gland Scaled Score (PASS): Can They Predict Malignancy?
Authors: Agarwal Amit , Mehrotra Prateek K. , Jain Manoj , Gupta Sushil K. , Mishra Anjali , Chand Gyan , Agarwal Gaurav , Verma A. K. , Mishra S. K. , Singh Uttam
Published: August 2010

Background

Size can predict malignancy in adrenocortical tumors, but the same extrapolation for pheochromocytomas (PCC) is controversial. The goal of this study was to find a correlation between the tumor size and malignant potential of PCC and determine whether the “Pheochromocytoma of the adrenal gland scaled score” (PASS) proposed by Thompson can be applied to predict malignancy.

Methods

A retrospective analysis of patients with PCC operated on from 1991 to 2007 revealed 98 PCC removed from 93 patients. Tumor size was available for 90 tumors. Six (6.4%) patients had proven malignancy. Five familial cases were excluded from the PASS analysis.

Results

Of the benign cases, none developed recurrence or metastasis. There were 54 (60%) tumors > 6 cm and 36 (40%) tumors ≤ 6 cm. All 12 PASS parameters were individually present in higher frequency in the >6‐cm group; but the difference was not statistically significant except cellular monotony (p = 0.02). Overall, a PASS ≤ 4 was found in 57 patients. Mean PASS was statistically significantly higher in the >6‐cm group (4.4 vs. 3.3, p = 0.04). Of the sporadic benign cases, 21 (41%) patients with tumor size > 6 cm had a PASS of >4, and none of them developed metastasis. PASS ≤ 4 was found in 25 (81%) PCC in the ≤6‐cm group, and none developed metastases. PASS ≥ 4 was found in six (19%) patients in the ≤6‐cm group, and none developed metastases. 68 patients completed 5‐year follow‐up, and the remaining had a mean follow‐up of 28.7 months. No correlation was found between tumor size and PASS > 4 and PASS ≤ 4 (7.8 cm vs. 7.1 cm; p = 0.23).

Conclusions

Presently there is not enough evidence to indict a large (>6 cm) PCC as malignant. Furthermore, PASS cannot be reliably applied to PCC for predicting malignancy.
Prognostic Significance of Ki‐67 Labeling Index in Papillary Thyroid Carcinoma
Authors: Ito Yasuhiro , Miyauchi Akira , Kakudo Kennichi , Hirokawa Mitsuyoshi , Kobayashi Kaoru , Miya Akihiro
Published: August 2010

Background

Ki‐67 is a useful tool for evaluating cell proliferative activity in various tumors. Although the utility of Ki‐67 labeling index (LI) to diagnose thyroid neoplasms has been investigated, little is known regarding the relationship between Ki‐67 LI and the biological behavior of papillary thyroid carcinoma. In this study, we examined Ki‐67 in 371 patients with papillary thyroid carcinoma to elucidate this issue.

Methods

A total of 371 patients with papillary carcinoma who underwent initial and locally curative surgery between 1996 and 1997 were enrolled in this study. We immunohistochemically investigated Ki‐67 LI in their primary lesions and compared this finding with various clinicopathological features, including patient prognosis.

Results

Ki‐67 LI was ≤1% in 213 patients (57%) and among the remaining 158, 35 showed Ki‐67 LI >3%. Ki‐67 LI was associated with patient age, massive extrathyroid extension, and distant metastasis at surgery. Of 363 patients without distant metastasis at surgery, 54 (15%) showed carcinoma recurrence during follow‐up (average 124 months) and the disease‐free survival (DFS) of patients with Ki‐67 LI >1% was significantly worse than that of those with Ki‐67 LI <1% (p < 0.0001). On multivariate analysis, Ki‐67 LI was recognized as an independent prognostic factor for the DFS of patients. Although only eight patients died of carcinoma in our series, patients with Ki‐67 LI >3% showed a significantly worse cause‐specific survival (CSS) than those with Ki‐67 LI <3% (p < 0.0001).

Conclusions

Careful evaluation of Ki‐67 LI in primary lesions can predict DFS and CSS of patients with papillary thyroid carcinoma.
Clinical Implication of the Number of Central Lymph Node Metastasis in Papillary Thyroid Carcinoma: Preliminary Report
Authors: Lee Yoon Se , Lim Yun Sung , Lee Jin‐Choon , Wang Soo‐Geun , Kim In‐Ju , Lee Byung‐Joo
Published: August 2010

Background

Papillary thyroid cancer (PTC) metastasizes to central lymph node (CLN). CLN metastasis is associated with high risk of locoregional recurrence and distant metastasis. The significance of the number of metastatic CLN has not been addressed. This study was designed to evaluate the clinical implication of the number of metastatic CLN in PTC.

Methods

We reviewed the patients who underwent total thyroidectomy and CLN dissection with or without lateral neck dissection due to PTC, from March 2008 to June 2009. The relationships between the number of CLN and risk factors, including age, gender, tumor size, extrathyroidal extension, and lateral lymph node metastasis, were assessed. Patients were divided into three groups according to the number of CLN: group A = 0; group B = 1–2; and group C = ≥3.

Results

Of 258 patients enrolled in this study, 113 were in group A, 73 in group B, and 72 in group C. Extrathyroidal extension and lateral neck lymph node metastasis were related to increased rate of CLN metastasis (P < 0.05). Tumor size increased as the number of CLN increased; group C had the largest tumor size (P < 0.05). When evaluating the distribution of patients with extrathyroidal extension, group C had a significant odds ratio (4.213, P < 0.05). When evaluating the distribution of lateral neck lymph node metastasis, groups B and C had significant odds ratio (14.353, 75.403, respectively, P < 0.05).

Conclusions

The number of CLN metastasis correlated with the negative prognostic factors, including tumor size, extrathyroidal extension, and lateral neck lymph node metastasis. This suggests that the number of CLN has prognostic implication.
Pancreatoduodenectomy With or Without Early Ligation of the Inferior Pancreatoduodenal Artery: Comparison of Intraoperative Blood Loss and Short‐Term Outcome
Authors: Ishizaki Yoichi , Sugo Hiroyuki , Yoshimoto Jiro , Imamura Hiroshi , Kawasaki Seiji
Published: August 2010

Background

Some of the significant predictive risk factors for complications after pancreatoduodenectomy are increased intraoperative blood loss and the need for blood transfusion. The impact of pancreatoduodenectomy (PD) with early ligation of the inferior pancreatoduodenal artery (IPDA) on intraoperative blood loss and short‐term outcomes is not well known.

Methods

A retrospective review of patients who underwent standard PD (n = 112) and pancreatoduodenectomy with early ligation of the IPDA (n = 175) was undertaken.

Results

Early ligation of the IPDA, body mass index, sex, and operative time were independent risk factors for intraoperative blood loss. Intraoperative median blood loss in patients with early ligation of the IPDA was 380 ml, which was significantly lower than 850 ml in patients who had a standard PD (p < 0.001). Although 51 patients (46%) with standard PD needed a perioperative blood transfusion, only four patients (2%) with early ligation of the IPDA received a perioperative red cell transfusion (p < 0.001). The overall complication rates were 61% for patients with standard PD versus 45% for patients with early ligation of the IPDA (p = 0.007). There were five in‐hospital deaths (4.5%) of patients with standard PD versus zero in‐hospital deaths (0.0%) of patients with early ligation of the IPDA (p = 0.002).

Conclusion

Early ligation of the inferior pancreatoduodenal artery not only reduced intraoperative blood loss during PD but also alleviated postoperative morbidity and mortality.
Socio-economic patterns of sport demand and ageing
Authors: Breuer Christoph , Hallmann Kirstin , Wicker Pamela , Feiler Svenja
Published: August 2010

Due to the demographic situation in nowadays societies, physical activity, and sport expenditure have to be analysed from a demographic as well as socio-economical perspective. This means that determinants such as age, gender, nationality/ethnicity, income, time, educational level, profession, and social status have to be taken into account. However, when comparing the various studies, the different methods of analysis and different operationalisation of variables have to be considered. This is in particular vital investigating age. Whilst cross-sectional studies point out that physical activity generally decreases with increasing age, longitudinal analyses come to different results. Previous studies indicate that pertaining to gender more men take part in sports than women. However, considering period and cohort effects, recent longitudinal studies showed that women participate more in sport than in the past. Besides, it was found out that men generally tend to spend more money on sports than women do. A further finding is that the educational level influences physical activity positively. Research revealed that income had a positive impact on both, physical activity and sport expenditure.
Increased Lipid Peroxidation in LDL from Type‐2 Diabetic Patients
Authors: Colas Romain , Pruneta‐Deloche Valérie , Guichardant Michel , Luquain‐Costaz Céline , Cugnet‐Anceau Christine , Moret Myriam , Vidal Hubert , Moulin Philippe , Lagarde Michel , Calzada Catherine
Published: August 2010

Increased oxidative stress is associated with type‐2 diabetes and related cardiovascular diseases, but oxidative modification of LDL has been partially characterized. Our aim was to compare the lipid and fatty acid composition as well as the redox status of LDL from diabetic patients and healthy subjects. First, to ensure that isolation of LDL by sequential ultracentrifugation did not result in lipid modifications, lipid composition and peroxide content were determined in LDL isolated either by ultracentrifugation or fast‐protein liquid chromatography. Both methods resulted in similar concentrations of lipids, fatty acids, hydroxy‐octadecadienoic acid (HODE) and malondialdehyde (MDA). Then, LDLs were isolated by ultracentrifugation from eight type‐2 diabetic patients and eight control subjects. Compared to control LDL, diabetic LDL contained decreased cholesteryl esters and increased triglyceride concentrations. Ethanolamine plasmalogens decreased by 49%. Proportions of linoleic acid decreased in all lipid classes, while proportions of arachidonic acid increased in cholesteryl esters. Total HODE concentrations increased by 56%, 12‐ and 15‐hydroxy‐eicosatetraenoic acid by 161 and 86%, respectively, and MDA levels increased by twofold. α‐Tocopherol concentrations, expressed relative to triglycerides, were lower in LDL from patients compared to controls, while γ‐tocopherol did not differ. Overall, LDL from type‐2 diabetic patients displayed increased oxidative stress. Determination of hydroxylated fatty acids and ethanolamine plasmalogen depletion could be especially relevant in diabetes.
A cytotoxic peptide from a marine sponge exhibits ion channel activity through vectorial‐insertion into the membrane
Authors: Iwamoto Masayuki , Shimizu Hirofumi , Muramatsu Ikunobu , Oiki Shigetoshi
Published: August 2010

A cytotoxic peptide, polytheonamide B (pTB), from marine sponge was examined for cytotoxic spectrum and specific activity to mammalian cells was demonstrated. pTB is composed of alternative D‐ and L‐amino acid residues throughout the 48‐mer peptide. This suggests the formation of a β‐helix similar to gramicidin channels. Planar bilayer experiments revealed that pTB forms monovalent cation‐selective channels, being compatible with the inner pore diameter of ∼4 Å for a β‐helical structure. pTB penetrated vectorially into the membrane, formed a channel by means of a single molecule, and remained in the membrane. These functional properties may account for specific cytotoxic activity.
Quality of Life and its Correlates in Patients With Obsessive‐compulsive Disorder
Authors: Hou Shu‐Ying , Yen Cheng‐Fang , Huang Mei‐Feng , Wang Peng‐Wei , Yeh Yi‐Chun
Published: August 2010

The care of patients with obsessive‐compulsive disorder (OCD) has raised quality of life (QOL) issues. The purpose of this study was to compare the level of QOL between patients with and without OCD, and to examine the associations between QOL and sociodemographic data, course of illness, psychopathology, perceived social support, and treatment characteristics. The QOL levels measured with the Taiwan version of the Short Form of the World Health Organization Questionnaire on Quality of Life were compared between 57 subjects with OCD and 106 subjects without OCD. The correlates of QOL were examined among subjects with OCD. The analysis revealed that QOL scores for the general, physical, psychological and social relationship domains were lower in the OCD group than in the control group; however, no difference in the environmental domain was found. Multiple factors were associated with poor QOL in subjects with OCD, including comorbid depression, severe obsession symptoms, perceived low social support, severe adverse effects of medication, combined use of mood stabilizers, and low social status. Different domains of QOL are differently affected by OCD. The QOL of subjects with OCD was correlated to multiple factors that were specific to individual subjects and influenced by interactions with treatment and the social environment.