bluuebunny/crossref_metadata_2025 huggingface dataset:
Priority areas for the use of solar water disinfection (SODIS) in Brazil: a spatial approach
Authors: Kondo Nakada Liane Yuri , Urban Rodrigo Custodio
Published: September 2024

This paper presents a methodology for the development of a potential and priority use map for the application of the solar water disinfection (SODIS) method in Brazil. The assessment of solar radiation was conducted, with a particular focus on the annual average global horizontal irradiance (GHI). The water vulnerability index (WVI) and the economic-social-ecosystemic (ESE)-WVI were developed and employed as indicators to define the priority regions for the application of SODIS. The combination of the GHI and WVI maps yielded a SODIS usage potential index (SUPI). The combination of the SUPI map with information pertaining to the human, economic, and ecosystem dimensions of water vulnerability (ESE-WVI) yielded the SODIS usage priority index. The analysis revealed that the country exhibits favorable levels of solar radiation, making the implementation of SODIS a viable option, particularly in the Northeast region. Furthermore, the study identified regions with greater water vulnerability, such as the semi-arid region and some parts of the Amazon, as priorities for the application of SODIS. In conclusion, SODIS represents a viable water treatment technique for various regions in Brazil, particularly those with abundant solar radiation and concerns regarding water security.
FÁBRICA DE IDEIAS E INOVAÇÃO
Authors: MENDONÇA LINO LIMA ZAMBON DE , SUASSUNA BRUNA , Monteiro Verner
Published: September 2024

A construção em aço ainda é, em grande medida, um mito em algumas escolas de arquitetura. A formação brasileira, de modo geral, ainda é fortemente influenciada pelo modernismo, que tem no concreto armado a representação de material e sistema estrutural incontestáveis. Contudo, a contemporaneidade tenta romper as barreiras e difundir o uso de materiais alternativos. Uma das alternativas principais é o aço, que lança oportunidade de soluções mais diversas e ousadas, uma vez que possibilita uso de balanços, atirantamentos e vãos maiores. Este artigo tem como objetivo apresentar um projeto concebido em aço para o concurso do Centro Brasileiro da Construção em Aço, o CBCA, focando na apresentação do processo de projeto e da proposta as soluções arquitetônicas e estruturais utilizadas. O manuscrito mostra, ainda, os bastidores do que precisou ser preparado nas etapas da competição, revelando os principais desafios colocados à equipe de projeto.
RAÍZES ANTIGAS, NOVAS HISTÓRIAS
Authors: Mendes Junior Edvaldo , Farias Helio T M
Published: September 2024

Os parques públicos aparecem no século XVIII como uma alternativa às transformações sociais e espaciais sofridas pela cidade pós-industrial. O crescimento urbano desordenado, o aumento da poluição e o adoecimento físico e mental proveniente do caos urbano faz destes espaços verdes verdadeiros oásis; locais com potencial de proporcionar inúmeros benefícios aos cidadãos. No caso do Parque Boca da Mata, em Ceará-Mirim/RN, este potencial não tem sido plenamente aproveitado. O local possui uma área de cerca de 69 hectares legalmente protegida, que abraça uma zona de resquício de Mata Atlântica, importante bioma brasileiro. Apesar de ser uma área, em tese, destinada à população para o exercício da ciência, da cultura e do lazer, o local carece de qualquer infraestrutura de suporte à sua utilização, além de zonas em processo de contínua degradação. Desta forma, o presente trabalho vem estudar a área e apontar soluções que insiram o local no cotidiano da população, com o objetivo de apresentar uma proposta de área visitável dentro do Parque Boca da Mata, respeitando seu entorno, contemplando as necessidades dos cidadãos e considerando ideais de recuperação ambiental e democratização de seus espaços. As soluções apontadas procuraram considerar os contextos urbano, socioeconômico e natural do Parque Boca da Mata, a fim de traçar os melhores caminhos de intervenção e propiciar desenvolvimento harmônico entre a cidade, sociedade e o meio-ambiente.
Transcranial Magnetic Stimulation: A New Possibility in Obesity Treatment
Authors: La Marra Marco , Monda Antonietta , Monda Marcellino , Villano Ines , Chieffi Sergio , Ricci Mariateresa , Sapuppo Walter , De Pascale Germana , Allocca Salvatore , Casillo Maria , Moscatelli Fiorenzo , Messina Antonietta , Monda Vincenzo , Di Maio Girolamo
Published: September 2024

Obesity is a major public health challenge and results from the complex interaction of many etiopathogenetic factors. However, food-related hedonic stimuli and poor inhibitory control often appear to be specific maintenance factors, and conventional treatments are sometimes ineffective. Transcranial magnetic stimulation is emerging as a promising treatment option. Targeting specific brain regions, such as the dorsolateral prefrontal cortex, was found to be effective in modulating acute food craving and improving cognitive control. This review traces the evolution and development of transcranial magnetic stimulation and presents the results of recent randomized clinical trials conducted in obese subjects. These suggest that repetitive transcranial magnetic stimulation and deep transcranial magnetic stimulation may be effective in reducing body weight, BMI and food cravings. The neural circuits involved and the underlying mechanisms of action of this neurostimulation technique are also reviewed. Finally, outstanding questions and future research directions are identified to further understand and develop this promising therapy.
Congenital Hypothyroidism
Authors: Bernal Juan
Published: September 2024

Congenital hypothyroidism is a thyroid hormone deficiency disorder present
at birth due to thyroid gland failure. There are two types: primary and central. Primary
congenital hypothyroidism is caused by either developmental disorders of the thyroid
gland or defects in thyroid hormone synthesis. The central type, which is much less
common, is caused by decreased TSH secretion or bioactivity. Thyroid dysgenesis and
dyshormonogenesis are the major causes of congenital hypothyroidism. Most cases are
multifactorial, involving several genes, and a small percentage is monogenic. Thyroid
failure occurs prenatally, but maternal thyroid hormones may prevent fetal
hypothyroidism and protect the brain. Untreated congenital hypothyroidism severely
affects postnatal development, but neonatal screening allows for early thyroid hormone
treatment, effectively preventing hypothyroidism.
How Thyroid Hormones Shape the Brain
Authors: Bernal Juan
Published: September 2024

This chapter provides a comprehensive exploration of the role of thyroid
hormones in the development of key brain structures: the cerebral cortex, hippocampus,
striatum, and cerebellum, as well as the sense organs retina and cochlea.
Hypothyroidism is generally associated with impairments in axodendritic development,
synaptogenesis, neuron migration and differentiation, and myelination. In the
developing cerebral cortex, hypothyroidism delays the appearance of Cajal-Retzius
cells, critical for the proper migration of neurons, causing migration defects. The
maturation of the transient subplate layer, crucial for establishing thalamocortical
connections, is also delayed. The hippocampal formation experiences a reduction in the
number of granular cells and mossy fibers. In the cerebellum, hypothyroidism arrests
the maturation of the Purkinje cells and delays the migration of the granular cells to the
internal granular layer. In the striatum, hypothyroidism delays the accumulation of the
medium-spiny GABAergic neurons, the principal cells of the striatum. Parvalbumin
interneurons in the cerebral and cerebellar cortices are also affected. Thyroid hormone
induces extensive remodeling during cochlear and retinal maturation. Contrary to
expectations, receptor-deficient mice often do not exhibit these alterations, while the
expression of mutant receptors with impaired T3 binding results in hypothyroid
features. In rodents, the effects of thyroid hormones are most prominent during the
postnatal period. Conversely, in humans, the second trimester of pregnancy is a crucial
period for neural development. The coordinated development of the thyroid hormone
signaling system, encompassing brain T3 and the ontogenesis of receptors, deiodinases,
and regulated genes, closely aligns with late maturational processes. This intricate
interplay underscores the significance of thyroid hormones in shaping the structural and
functional aspects of the developing brain.
Thyroid Hormones and Mood Disorders
Authors: Bernal Juan
Published: September 2024

Thyroid hormone deficiency or excess may cause emotional disturbances
and mood disorders, encompassing major depressive syndromes and bipolar disorders,
along with various other neuropsychiatric conditions, some of which may have
developmental origins. In particular, profound long-term untreated hypothyroidism can
culminate in severe psychosis, historically referred to as myxedema madness.
Addressing the underlying thyroid condition typically proves highly effective in
rectifying the associated brain disorder. Subclinical thyroid diseases have also been
implicated in emotional and cognitive disorders, prompting inquiry into the optimal
treatment window. Moreover, thyroid hormones have demonstrated potential in
expediting or augmenting the effects of standard mood disorder treatments in euthyroid
patients, hinting at a baseline state of localized cerebral hypothyroidism with an
uncertain pathogenesis, potentially remediable through high doses of thyroid hormones.
Plac Marszałka Józefa Piłsudskiego – trwały element w przestrzeni Warszawy Od otoczenia Soboru do końca II wojny światowej
Authors: Wieczorek Anna , Gorzelak Magnolia
Published: September 2024

O warszawskim Placu Marszałka Józefa Piłsudskiego i otaczających go budynkach można przeczytać w wielu książkach i artykułach dotyczących dziejów stolicy oraz historii architektury i urbanistyki. Istnieją również spore zasoby kartograficzne i ikonograficzne w muzeach i archiwach. Analiza materiałów źródłowych wskazuje na duże rozproszenie informacji. Brakuje kompendium wiedzy dotyczącej genezy powstania Placu, zmian w jego wyglądzie i związanej z tym myśli projektowej. Tym zagadnieniom poświęcony jest cykl artykułów o wspólnym tytule Plac Marszałka Józefa Piłsudskiego – trwały element w przestrzeni Warszawy. Niniejszy artykuł, trzeci w tym cyklu, opisuje jak zmieniał się wygląd Placu w latach 1918–1945, przechodząc od otoczenia Soboru do ruin II wojny światowej oraz przybliża postać patrona Placu – Józefa Piłsudskiego. Słowa kluczowe: Plac Marszałka Józefa Piłsudskiego, Pałac Saski, Pałac Brühla, Oś Saska, Józef Piłsudski
Effectiveness of Internet-Based Telehealth Programs in Patients With Hip or Knee Osteoarthritis: Systematic Review and Meta-Analysis
Authors: Wang Hao-Nan , Luo Pei , Liu Shuyue , Liu Yunyi , Zhang Xiao , Li Jian
Published: September 2024

Background

Osteoarthritis (OA) is a chronic musculoskeletal disease that causes pain, functional disability, and an economic burden. Nonpharmacological treatments are at the core of OA management. However, limited access to these services due to uneven regional local availability has been highlighted. Internet-based telehealth (IBTH) programs, providing digital access to abundant health care resources, offer advantages, such as convenience and cost-effectiveness. These characteristics make them promising strategies for the management of patients with OA.

Objective

This study aimed to evaluate the effectiveness of IBTH programs in the management of patients with hip or knee OA.

Methods

We systematically searched 6 electronic databases to identify trials comparing IBTH programs with conventional interventions for hip and knee OA. Studies were selected based on inclusion and exclusion criteria, focusing on outcomes related to function, pain, and self-efficacy. Standardized mean differences (SMDs) with 95% CIs were calculated to compare outcome measures. Heterogeneity was assessed using I² and χ² tests. The methodological quality of the selected studies and the quality of evidence were also evaluated.

Results

A total of 21 studies with low-to-high risk of bias were included in this meta-analysis. The pooled results showed that IBTH has a superior effect on increasing function (SMD 0.30, 95% CI 0.23-0.37, P<.001), relieving pain (SMD –0.27, 95% CI –0.34 to –0.19, P<.001), and improving self-efficacy for pain (SMD 0.21, 95% CI 0.08-0.34, P<.001) compared to the conventional intervention group. Subgroup analysis revealed that IBTH with exercise can significantly alleviate pain and improve function and self-efficacy, but IBTH with cognitive-behavioral therapy only had the effect of reducing pain.

Conclusions

The meta-analysis provides moderate-quality evidence that IBTH programs have a beneficial effect on improving function, relieving pain, and improving self-efficacy compared to conventional interventions in patients with hip or knee OA. Limited evidence suggests that the inclusion of exercise regimens in IBTH programs is recommended.

Trial Registration

PROSPERO CRD42024541111; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=541111
Clinical Decision Support Systems to Identify Drug-Related Problems in Diabetes Mellitus Patients: A Systematic Review
Authors: Larasati Niken , Satibi Satibi , Kristina Susi Ari , Lazuardi Lutfan
Published: September 2024

Clinical Decision Support Systems (CDSSs) has been developed for utilization to provide rational therapy to Diabetes Mellitus (DM) patients including preventing Drug-related Problems (DRPs) such as the effect of drug treatment being not optimal, untreated indications and symptoms, unnecessary therapy, and adverse drug reactions. This study aims to summarize the available evidence on the intervention of CDSSs, key outputs, and impact of the user in DM patients. This study was a systematic review using PubMed, Scopus database, and by manually searching the bibliographies of articles that have been found. We included studies reporting on evaluated CDSSs that had been implemented in medication prescription, reducing medication errors, adverse drug events, drug-allergy checking, drug dosing support, and so on.  A total of 8 studies were selected among 855 studies. CDSSs are used in hospitals and primary care settings to identify potential drug interactions, correct therapy regimens, monitor therapy, blood glucose documentation, ensure patients receive medication according to the guideline, provide nutritional advice, and schedule physical activity. The usage of CDSSs improves blood glucose levels, detects possible drug interactions, reduces face-to-face consultations, improves documentation, assists in identifying dose, and promotes prescribing in line with the guideline. The use of CDSSs can help to reduce the risk of errors in management therapy.
Zinc Sulfate and α-tocopherol Supplementation Enhance Reproductive Performance in Male Albino Rats (Rattus norvegicus) With Lead Acetate Toxicity
Authors: Prastiya Ragil Angga , Sardjito Trilas , Agustono Bodhi , Fikri Faisal , Saputro Amung Logam , Wurlina Wurlina , Dewi Basmala Launa , Pratiwi Sherly Mega , Nugroho Aras Prasetiyo , Moses Ikechukwu Benjamin
Published: September 2024

Metal toxicity from lead affects reproductive organ function by activating reactive oxygen species processes. This study aims to see how α-tocopherol and zinc sulfate (ZnSO4) affect gonads, liver, follicle-stimulating hormone, luteinizing hormone, spermatogenesis (the amount of spermatogonia, spermatocytes, and spermatids), and Leydig cells in male albino rats (Rattus norvegicus) exposed to lead acetate Pb(CH3COO)2. The samples used were 25 male Wistar rats aged 4 months, separated into five groups. For 30 days, all treatment groups were exposed to Pb(CH3COO)2 at a level of 50-mg/kg body weight (BW). The T1 group was given a dosage of 100-mg/kg BW of α-tocopherol. The ZnSO4 was given to the T2 group at a dose of 0.54-mg/kg BW. Meanwhile, the T3 group was given a mixture of ZnSO4 at 0.54-mg/kg BW and α-tocopherol at 100-mg/kg BW orally. ELISA test was carried out to determine the level of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in a blood plasma sample of 100 μl / 1 mg. Histopathological observations made on the liver included counting damaged cells and seminiferous tubules that included counting the amount of spermatogonia, spermatocytes, spermatids, Sertoli cells, and Leydig cells. Using SPSS 20 software, the collected data were analyzed using analysis of variance, followed by Duncan’s test with a 95% simultaneous confidence level. The highest average levels of FSH and LH in the T3 group were 3.6162 mIU/mL and 14.9658 mIU/mL. The finding showed that Pb(CH3COO)2 caused disruptions in the spermatogenesis and Leydig cell processes. Exogenous antioxidants in combination with ZnSO4 and α-tocopherol had significant effect on enhancing reproductive performance in animals exposed to Pb(CH3COO)2.
Isolation of Nutmeg Essential Oil (Myristica fragrans houtt) From Aceh Indonesia and Their Antioxidant and Antibacterial Activities
Authors: Khairan Khairan , Faradilla Meutia , Ginting Binawati
Published: September 2024

This study aims to isolate the nutmeg essential oil (Myristica fragrans Houtt) from Aceh Indonesia and evaluate their biological activity. The antioxidant activity of the nutmeg essential oils (Myristica fragrans Houtt) was determined by DPPH (1,1-difenil-2-pikrihidrazil) assay. The DPPH assay showed that arillus essential oil (AMFH) has the highest antioxidant activity with the IC50 values was 216,695 ppm. The chemical composition of the AMFH was perfomed by Gas Chromatography-Mass Spectroscopy (GC-MS), and the results showed that AMFH contains Terpinen-4-ol (T-4-ol), α-Terpineol (α-T), Safrole (Saf) and Myristicin (Myr) with the percentage area of 11.20%; 1.83%; 5.10%; and 27.80% respectively. The AMFH was isolated by column chromatography and four fractions were obtained, namely AMFH1; AMFH2; AMFH3; and AMFH4 fractions. The DPPH assay showed that the AMFH3 fraction showed excellent antioxidant activity with the IC50 values of 59.329 ppm. The AMFH3 fraction was than reisolated by using by column chromatography to obtain four subfractions namely AMFH3A; AMFH3B; AMFH3C; and AMFH3D. The DPPH assay showed that the subfraction of AMFH3A has the highest antioxidant activity with the IC50 values of 98.993 ppm. The antibacterial activity of AMFH3A subfractions was evaluated by Kirby Bauer-Disc diffusion method, and the results showed that AMFH3A subfraction showed slightly higher activity against Staphylococcus epidermidis and Staphylococcus aureus with the diameter inhibition of 14.28 mm and 12.26 mm respectively. The chemical composition of the AMFH3A subfraction was performed by GC-MS, and the results showed that AMFH3A subfraction contains Terpinen-4-ol (T-4-ol), α-Terpineol (α-T), Safrole (Saf) and Myristicin (Myr) with the percentage area of 14.37%; 2.16%; 7.36%; and 54.77% respectively.
Simultaneous Quantification of Ramipril and Ramiprilat in Drug Formulations: A Clinical LC-MS/MS Study
Authors: Omari Khaled , Abu-Awwad Ahmed , Arafat Basel , Macovei Gianina , Boltez TLucretia , Abdel Baki Zaher , Mallah Eyad , Arafat Tawfiq
Published: September 2024

Ramipril is a drug controlling hypertension. Two drugs were studied in 36 healthy adults. The drugs are the test (Atb®) and the reference (Tritace®). This concept is crucial in the pharmaceutical industry during the development process. The maximum concentration (Cmax) of Ramipril and its metabolite (Ramiprilat) were determined throughout drug administration in healthy subjects. All analysis was performed using LC-MS/MS. The method was validated over a range of 0.200 – 25.000 ng/mL in which linearity (R2) was 0.9983, accuracy was 99.9%, precision (CV) was less than 20%, and the Lower Limit of Quantitation was 0.200 ng/mL. Stability and other parameters were discussed. The time needed to reach this concentration (Tmax) and the time-drug concentration area under the curve (AUC) were most agreed upon. The two drugs were proven to be interchangeable. Both have similar pharmacokinetics and bioequivalence profiles. Consequently, the drugs are bioequivalent and considered alternatives to one another pharmaceutically. For example, 90% confidence intervals (C.I.) for the in-tra-individual ratios (test/reference) for pharmacokinetic parameters were Cmax, and AUC0-t for total exposure C.I. Log – transformed Values were 80-125 %.
Comparative Cellular and In Vivo Anti-cancer studies of Doxorubicin Liposomes Prepared with Different Types of Phospholipids
Authors: Miatmoko Andang , Cahyani Devy Maulidya , Kawano Kumi , Hattori Yoshiyuki
Published: September 2024

The selection of lipid components of membrane bilayer determines the rigidity of liposomes affecting drug efficacy, especially for cancer drug delivery. The present study evaluated liposomes with different rigidity for delivering doxorubicin (DOX). In this work, liposomes composed of rigid lipid, hydrogenated soybean phosphatidylcholine (HSPC), were totally or partially substituted with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). The liposomes are composed of phosphatidylcholine (HSPC, POPC), with and without combination with DOPE, cholesterol, and DSPE-mPEG2000 with a molar ratio of 57: 38: 5, respectively. Liposomes were prepared using a thin layer hydration method. Then, in vitro cytotoxicity and in vivo antitumor activity of these liposomes were evaluated.  Substitution of HSPC with POPC resulted in similar cytotoxicities profiles similar to the DOX solution on C26 colon cancer cells and LLC cells. The DOPE addition to DOX liposomes reduced the antitumor activity. In conclusion, the lipid substitution of HSPC with POPC or DOPE reduced liposome rigidity; however, it lowered the in vivo antitumor activity.
Identifying Pronunciation Challenges for Cantonese EFL Learners: A Focus on Intelligibility
Authors: Zhang Xinting , Li Yuan
Published: September 2024

This study investigates the intelligibility of Cantonese-accented English by examining segmental pronunciation errors and their impact on native English listeners’ ability to accurately transcribe spoken sentences. Building on a previous production experiment, this research focuses on identifying which vowel and consonant mispronunciations most hinder intelligibility. Ten native English listeners transcribed 1,000 sentences produced by Cantonese speakers, and transcription accuracy was calculated for each target sound. The results reveal that dark /l/ (e.g., “cold”), final consonants like /g/ (e.g., “bag”), and the vowel /æ/ (e.g., “pan”) had the lowest accuracy rates, while sounds like /n/ (e.g., “no”) and /ʃ/ (e.g., “sheep”) were consistently transcribed correctly. These findings highlight the importance of targeting specific pronunciation difficulties in Cantonese EFL learners to improve intelligibility. The study supports the prioritization of intelligibility over accent reduction in pronunciation instruction, providing practical implications for teaching pronunciation in Cantonese-speaking contexts.
El estilo juvenil de comunalizar: agencia de jóvenes indígenas profesionistas de Oaxaca
Authors: Ramos Arcos Víctor Hugo
Published: September 2024

El artículo tiene como objetivo analizar los aprendizajes, dinámicas y contextos sociales que hacen factible la agencia de jóvenes indígenas profesionistas en el marco de las lógicas comunitarias. Desde una metodología cualitativa, se captaron las experiencias educativas y profesionales de estos jóvenes y se identificaron los actores e instituciones transmisoras de saberes, aprendizajes y herramientas que les permitieron formarse como actores comunitarios. Se analiza la agencia de estos profesionistas a través de revisar cómo inciden sobre equidad de género en distintos escenarios y cómo forjan un estilo generacional de comunalizar que entrelaza lo comunitario con su condición juvenil y profesional. Se concluye que estos jóvenes, con su agencia emergente, específica y diferente, se posicionan como actores que mantienen vigente la vida comunitaria.
Metástasis cerebral múltiple de adenocarcinoma pancreático. Reporte de caso
Authors: Alonso Bracho Sofía Aranxa , Arroyo Zavala Octavio Jesús , Laredo Gómez Jenner , Vázquez Nieves José Roberto
Published: September 2024

Introduction: Brain metastases are the most common malignant lesions in the central nervous system. Brain metastases from pancreatic cancer are very rare, with poor prognosis.
The present paper aims to describe a rare pathology and the work carried out for the patient's care. Case report: 49-year-old man with personality changes, depression, and apathy. Five days before admission, he presented dysarthria, added left hemiparesis, and disorientation that progressed to sudden neurological deterioration that required advanced airway management. A computed tomography study was seen with cerebral cystic lesions. A decompressive craniectomy and drainage of the larger lesión was performed, with subsequent resection. The study protocol with immunohistochemistry reports CK 19, compatible with pancreatic adenocarcinoma.
Conclusions: A rare case of multiple brain metastases and suspected lung metastasis, both secondary to primary pancreatic adenocarcinoma was presented. The patient began with symptoms associated with brain lesions. The incidence of brain metastases with a primary pancreatic tumor is very low, and this is an exceptional case when presenting with neurological symptoms. Surgical resection of the brain lesion had a limited role in the clinical improvement of the patient since the progression of the disease was rapid. Still, it was useful to establish a diagnosis by immunohistochemistry. Since there are no screening tests for pancreatic tumors, it is difficult to identify them in early stages and without gastrointestinal symptoms.
Keywords: Pancreatic adenocarcinoma; brain tumors; brain metastases; cytokeratin 19; immunohistochemistry.
Industry-Specific Applications of Site Reliability Engineering
Authors: Augustin Jose
Published: September 2024

This article explores the application of Site Reliability Engineering (SRE) principles across various industries, demonstrating how SRE practices are being adapted beyond traditional tech companies to sectors such as healthcare, finance, and e-commerce. Originally developed by Google, SRE has evolved into a set of practices that bridge the gap between software development and IT operations, focusing on system reliability, performance optimization, and proactive problem-solving. The article examines specific case studies in each industry, highlighting the challenges faced during SRE implementation and the tangible benefits realized by organizations. By analyzing the impact of SRE on critical systems such as Electronic Health Records, high-frequency trading platforms, and e-commerce infrastructure, the article illustrates how SRE principles can be effectively applied to improve system reliability, enhance customer satisfaction, and increase operational efficiency across diverse business contexts.
A Survey on Role of Artificial Intelligence and Internet of Things in Sericulture
Authors: P. S. Sonal
Published: September 2024

This paper takes a deep dive into the captivating world of sericulture and the unique varieties of silk that have graced humanity throughout history. The work carried out in the paper provides an insight of exploring the different types of silk, including Muga Silk, Tussar Silk, Mulberry Silk and Eri Silk. Each of these silk has its own distinct qualities, weaving a rich tapestry of textures, colors and cultural significance that has enthralled people for generations. As the technological advancements have provided the interdisciplinary approach of understanding the role of artificial intelligence, machine learning and deep learning approaches in the area of sericulture, wide verities of techniques, methods and analysis are available in the literature. The paper aims at presenting an exhaustive literature survey on using AI based methods, applications in sericulture. In essence, this paper showcases the beautiful synergy of tradition and technology in sericulture
Multivariate analysis on students' cognitive assessment, attitude, and skill evaluation in problem-based learning
Authors: Santoso Sabar , Pramesti Getut
Published: September 2024

To improve the quality of education, the Ministry of Education and Culture of the Republic of Indonesia designed the "Merdeka" curriculum. With this curriculum, there are three learning outcomes, namely cognitive (knowledge), affective (character or attitude), and psychomotor (skills) domains. The learning that can be applied to the "MERDEKA" curriculum is the problem-based learning model. The significance of a variable in the learning process is very important to research to evaluate the learning process, especially in problem-based learning. Thus, the research objective of this study is to provide evidence of the significance of students’ cognitive assessment, attitude, and skill evaluation in mathematics learning. This study is a quantitative research using two-way multivariable analysis of variance (MANOVA), to determine the significance of cognitive assessment (assessment of learning outcomes), character or attitude, and skills evaluation in three classes of VIII students using problem-based learning (PBL). A two-way MANOVA analysis was carried out with students' class and gender factors, using measurement variables: cognitive assessment, attitude, and skill evaluation. From the results of the analysis, it was found that problem-based learning can be applied to Mathematics classes because, with this learning, both male and female students, the student's cognitive assessment is equally good in the significance level 5%. The differences in attitude and skill evaluation occurred because of the uniqueness of male and female students.
Informal contracts' influence on shipping efficiency: a customer- perspective of package delivery agent
Authors: Karamba Maryam , Musah Adiza
Published: September 2024

Understanding the role of informal agreements can help delivery services prioritize customer preferences, leading to improved service quality and customer satisfaction. Unfortunately, where there are gaps either on general understanding of communication stand in-between the different of failure and success. This qualitative research study delves into the dynamics of informal contracts between customers and package delivery agents, and their impact on the efficiency of the shipping process. The research aims to gain a deeper understanding of how these unwritten agreements affect various aspects of the delivery process from both the customer and delivery agent viewpoints. Through in-depth interviews and thematic analysis, this study sheds light on the nuances of these informal arrangements and their role in shaping the overall shipping experience. The study revealed that informal agreements play a significant role in package delivery experiences. Participants described unspoken arrangements formed through trust and effective communication. Adherence to these agreements positively influenced service efficiency, with prioritized deliveries and improved accuracy. However, deviations from agreements led to emotional reactions such as frustration and disappointment, impacting the perceived trustworthiness of the delivery service. Additionally, the study highlighted cultural variations in the adoption of informal agreements and the importance of clear communication in establishing and maintaining these arrangements.
Mitigating data inaccuracy and supply chain challenges in Western Romania's automotive industry
Authors: Turi Attila
Published: September 2024

The purpose of this paper was to emphasize the importance of data accuracy within internal logistics systems and their extended influence on supply chains in automotive industry through 6-month multiple case studies conducted on 3 first tier original equipment manufacturers (OEM) based in Western Romania. The study investigates the most common causes of data inaccuracies among automotive suppliers and their approaches to reduce consequential supply chain issues and be more agile. Data collection and analysis revealed that main issues arise due to ordering quantities mismatching actual customer demand, a wide range of order lot sizes, lead times and delivery reliability concerns and the reluctance to shift away from mainstream cost-effectiveness and towards strategic added value thinking. These issues sourced significant other related operational challenges such as excessive inventory, short-term stockouts and subsequent express shipping services or product-related inconveniences (quality and capacity levels, contracted volumes and dedicated lines). The paper sources different logistics and supply chain strategies used by the 3 OEMs, their features and operational performance, as well as their overall effectiveness, which can be applied by other automotive industry suppliers to improve own results. Introducing more reliable real-time data collection tools and performance metrics has started hauling more focus towards solving these prevalent issues with some ongoing improvement projects showing up to 25% better results. For one of the 3 OEMs introducing a new warehouse management system has already sourced an overall quality increase (5 percentage points) due to a 60% higher utilization of its production equipment.
Increasing the efficiency of logistics for the area of storage and picking of special materials
Authors: Pekarcikova Miriam , Trebuna Peter , Kopec Jan
Published: September 2024

The article deals with increasing the efficiency of logistics flows for the area of storage and picking. The aim of the processed study was to focus on the analysis of logistics activities and processes, the state of supply and inventory management. An assessment of the effectiveness of the introduced information system at the selected warehouse was carried out, which led to changes in a positive direction in the very process of storage and management of special products. The study presents the design of variants, the selection of the optimal one using selected decision-making methods and the introduction of a new warehouse system, which leads to the efficiency of the entire storage process in the NPI (New Product Introduction) warehouse. The output of the study is also the implementation of the selected variant into industrial practice, which is declared by the elaborated project of the introduction of the selected variant. The article is a contribution related to the process of implementing a warehouse and picking system for specialized material items.
Optimizing the order picking and delivery process to the final recipient
Authors: Kabus Judyta , Lenort Radim
Published: September 2024

The aim of this study is to analyse and evaluate the order picking process and the transport of products to customers, taking into account the specific characteristics and potential of small and medium-sized industrial enterprises. Scientific standards and selected indicators for measuring the efficiency and quality of transport and order picking processes were used to achieve the intended objectives. The research was conducted in a small, family-owned manufacturing and trading company specialising in the production and sale of wrought iron finishing elements and fences. The analysis covered both internal and external transport processes. It was shown that the order picking process in the studied company is largely based on manual procedures, which, despite high precision, generates time-consuming activities related to the movement of warehouse employees. External transport efficiency indicators showed high efficiency and appropriate use of transport resources. The high quality of deliveries, as measured by on-time and reliability indicators, confirms customer satisfaction. The study was conducted in one company, which is a limitation. Future studies should include more companies from the same sector. Proposed improvements need to be verified sometime after implementation and solutions resulting from data analysis can help SMEs in similar industries to improve their logistics processes. The work brings a new approach to the analysis of order picking and transport processes in the context of SMEs, providing practical solutions and indicating areas for further research. It is aimed at logistics managers, researchers and practitioners interested in optimising logistics processes in the industrial sector.
Extracellular matrix decellularization approaches for 3D tissue printing
Authors: Cajkova Jana , Trebunova Marianna , Bacenkova Darina
Published: September 2024

3D bioprinting holds transformative potential for the field of regenerative medicine, offering unprecedented opportunities for the fabrication of complex, living tissues. Central to this technological innovation is the development of suitable bioinks that can accurately replicate the native cellular environment. Decellularized extracellular matrix (dECM) has emerged as a promising candidate due to its inherent biocompatibility, bioactivity, and structural resemblance to native tissues. Decellularization is a crucial process in tissue engineering that involves the removal of cellular components from the extracellular matrix (ECM) to create scaffolds suitable for tissue regeneration. This article provides a review of some decellularization methods, categorizing them into physical, chemical, and biological approaches. The article discusses the advantages and limitations of each method, highlighting the need to balance effective decellularization with the preservation of the ECM’s functional properties. Understanding these methods is critical for developing optimized scaffolds for various tissue engineering applications.
Investigation of the influence of mechanical milling on magnetic properties of Fe powders
Authors: Provazkova Livia , Reiffers Marian , Rudeichuk Tetiana , Oleksakova Denisa
Published: September 2024

Nowadays, there is a global search for electromagnetic gadgets that are affordable, eco-friendly, and energy-efficient. This motivates engineers and scientists to develop new materials or enhance those that already exist. Fe-based soft magnetic materials are a significant class of soft magnetic materials that are essential to many energy-related industrial applications, including motors, converters, and electric transformers. This article focuses on the general characterization of magnetic materials, their magnetic properties and the analysis of the influence of mechanical milling of Fe powders prepared by mechanical milling in two different sizes (sample 1 – smaller then < 400 μm and sample 2 greater than > 400 μm). The experimentally obtained hysterical curves of ground Fe powders are measured using the Vibratimg Sample Magnetometer (VSM).
O tempo messiânico e a provisoriedade do tempo político
Authors: Westphal Euler
Published: September 2024

O tema deste ensaio discorre sobre o tempo messiânico e a relatividade do tempo político. O uso do mundo é condição e possibilidade de se viver o novo éon, a nova vida em Cristo, e o político faz parte dessa provisoriedade. Esse tema é abordado a partir do filósofo italiano Giorgio Agamben, em diálogo com autores da teologia, em especial o reformador Martinho Lutero. Ambos os autores são intérpretes do apóstolo Paulo, que tomam a carta aos Romanos como fundamento de seu pensamento. O problema está relacionado à interpretação messiânica de políticos brasileiros, que desconsideram a dimensão do tempo messiânico, o qual rompe com toda a possibilidade de entronização de messias políticos. O objetivo deste ensaio é analisar o conceito de tempo messiânico e buscar reflexões teológicas úteis para posicionamentos políticos relevantes. A metodologia é bibliográfica e conceitual, com foco na obra “O tempo que resta: Um comentário à Carta aos Romanos”, de Agamben. Como resultado, busca-se clarificar conceitos sobre a profanação das coisas do mundo a partir do tempo messiânico, como crítica aos messianismos políticos e religiosos.
Navigating success: Predicting corporate performance through organizational culture dynamics and governance
Authors: Abdelwahed Nadia Abdelhamid Abdelmegeed , Soomro Bahadur Ali
Published: September 2024

In the present era, every organization is anxious to enhance their productivity and performance. The success and sustainability of a business are possible through corporate performance, which helps fulfill organizational goals. The present study examines the effect of organizational culture (mission, involvement, consistency, and adaptability) on corporate performance in Egyptian manufacturing firms. The study is quantitative, and the firework is based on well-known studies like Kwarteng and Aveh (2018), Abukari et al. (2023), and Junca Silva and Pinto (2024). The study employed quantitative methods, where data were collected from employees of Egyptian manufacturing firms due to their consideration as valuable sources of organizational success. Finally, the study utilized 332 valid samples to infer the results. Through analysis of moment structures (AMOS), the path analysis suggests a positive effect of mission, involvement, and adaptability on corporate performance. On the other hand, consistency is a negative predictor of corporate performance in Egyptian manufacturing firms. The study findings would benefit policymakers and planners in enhancing the organizational culture to improve corporate performance, specifically among manufacturing and small and medium-sized enterprise (SME) firms in the developing context.
Sodium-Glucose Cotransporter-2 Inhibitors
Authors: White, Jr. John R. , Berlie Helen
Published: September 2024

Highlights: Introduction Pharmacology Treatment Advantages/Disadvantages Therapeutic Considerations Pharmacogenomics Adverse Effects and Monitoring Drug Interactions Combination Products Monographs References
Medications for Smoking Cessation
Authors: Clements Jennifer N. , Kim Anne P.
Published: September 2024

Highlights: Introduction First-Line Medications for Smoking Cessation Second-Line Medications for Smoking Cessation Combination Therapy for Smoking Cessation Monographs References
Medications for the Management of Hypoglycemia
Authors: Giruzzi Megan
Published: September 2024

Highlights: Introduction Hypoglycemic Prevention Treatment Options Glucagon Dasiglucagon Summary Monographs References
Immunizations and Diabetes
Authors: McKeirnan Kimberly C. , Rodin Nicole M.
Published: September 2024

Highlights: Introduction Vaccination Schedules Vaccines Conclusion References
Optical characterization of reduced graphene Based composite thin films: Left- Handed Materials (Metamaterials)
Authors:   ABIA STATE UNIVERSITY UTURU, ABIA STATE, NIGERIA, Sylvanus Cissan
Published: September 2024

Negative index material is a type of metamaterial with negative refractive index; being an artificial material, its fabrication is quite difficult, scaling up the production to meet the commercial demand is a challenge and the strong energy dissipation by metals poses another difficulty. This study employed a low cost, scalable technique (Electrodeposition) to synthesis Al and Ca doped NiO-ZnO-rGO thin films on fluorine doped tin oxide (FTO) without any complexing agents. The thin films were optically characterized using double Spectrophotometer within 300-1000 nm wavelength. Results reveal low absorption for all films but high transmittance of max. 78 % for luminum doped thin films. The incorporation of Al3+ and Ca2+ indicate the optical band gap of NiO-ZnO-rGO shifted to low energy (2.0 eV) and high energy (2.20 eV) respectively. All the composite thin films have unique features; negative refractive indexes, negative imaginary dielectric constant, and negative optical conductivity. These optical results of the films show they are novel left handed materials suitable for wider applications such as telemedicine, internet of things, transmission lines, energy storage devices, bio sensing, wearable devices etc.
Effect of Growth Conditions on Hemolysin Production from Clinical Isolates of Escherichia Coli
Authors: Juda Eman Khadum , Khalaf Khawlah Jebur , Salem-Bekit Mounir M
Published: September 2024

Background: Escherichia coli belongs to the Enterobacteriaceae family and is found in the digestive systems of humans and various animals as normal flora. Objective: This study aims to identify the optimal conditions necessary for the synthesis of hemolysin by E. coli isolated from a variety of clinical contexts. Methods: A total of 120 specimens were collected from different clinical sources in Baghdad Hospitals. Screening for hemolysin production was done by plate and Spectrophotometric methods. Furthermore, many conditions for producing hemolysin from clinical E. coli isolates were investigated including temperature, pH, incubation time, inoculum size, culture medium, and aeration. Results: Six isolates of E. coli exhibited hemolysin production. Optimal conditions for hemolysin production were determined: the temperature was 37 °C with an optical density of 0.931, the pH was 7 with an optical density of 0.976, the incubation period was 24 hours with an optical density of 0.885, 1% inoculum resulting in an optical density of 0.558, brain heart infusion as the best medium with an optical density of 1.697, and a shaker method showing superior results (optical density of 1.235) compared to static aeration (optical density of 0.988). Conclusions: This study identified the optimal conditions necessary for the synthesis of hemolysin by E. coli. By understanding these optimal conditions, researchers may be better equipped to develop strategies for managing and controlling the spread of these pathogenic bacteria.
A Transfer Learning Approach for Arabic Image Captions
Authors: Ibrahim Haneen Siraj , Shati Narjis Mezaal , Alsewari AbdulRahman A.
Published: September 2024

Background: Arabic image captioning (AIC) is the automatic generation of text descriptions in the Arabic language for images. Applies a transfer learning approach in deep learning to enhance computer vision and natural language processing. There are many datasets in English reverse other languages. Instead of, the Arabs researchers unanimously agreed that there is a lack of Arabic databases available in this field. Objective: This paper presents the improvement and processing of the available Arabic textual database using Google spreadsheets for translation and creation of AR. Flicker8k2023 dataset is an extension of the Arabic Flicker8k dataset available, it was uploaded to GitHub and made public for researches. Methods: An efficient model proposed using deep learning techniques by including two pre-training models (VGG16 and VGG19), to extract features from the images and build (LSTM and GRU) models to process textual prediction sequence. In addition to the effect of pre-processing the text in Arabic. Results: The adopted model outperforms better compared to the previous study in BLEU-1 from 33 to 40. Conclusions: This paper concluded that the biggest problem is the database available in the Arabic language. This paper has worked to increase the size of the text database from 24,276 to 32,364 thousand captions, where each image contains 4 captions.