bluuebunny/crossref_metadata_2025 huggingface dataset:
Discrete-Time Quantum Walk on Multilayer Networks
Authors: Jayakody Mahesh N. , Pradhan Priodyuti , Ben Porath Dana , Cohen Eliahu
Published: November 2023

A Multilayer network is a potent platform that paves the way for the study of the interactions among entities in various networks with multiple types of relationships. This study explores the dynamics of discrete-time quantum walks on a multilayer network. We derive a recurrence formula for the coefficients of the wave function of a quantum walker on an undirected graph with a finite number of nodes. By extending this formula to include extra layers, we develop a simulation model to describe the time evolution of the quantum walker on a multilayer network. The time-averaged probability and the return probability of the quantum walker are studied with Fourier, and Grover walks on multilayer networks. Furthermore, we analyze the impact of decoherence on quantum transport, shedding light on how environmental interactions may impact the behavior of quantum walkers on multilayer network structures.
The Influence of the Skin Phenomenon on the Impedance of Thin Conductive Layers
Authors: Pawłowski Stanisław , Plewako Jolanta , Korzeniewska Ewa , Sobczyński Dariusz
Published: November 2023

This paper analyzes the influence of the skin effect and the proximity effect on the inductance and impedance of thin conductive layers. The motivation for taking up this topic is the initial assessment of the possibility of using conductive layers deposited with the PVD technique on textile materials as strip or planar transmission lines of high-frequency signals (e.g., for transmitting images). This work pursues two goals. The first of them is to develop and test a numerical procedure for calculating the electromagnetic field distribution in this type of issue, based on the fundamental solution method (FSM). The second aim is to examine the impact of the skin phenomenon on the resistance, inductance and impedance of thin conductive paths. The correctness and effectiveness of FSM for the analysis of harmonics of electromagnetic fields in systems containing thin conductive layers were confirmed. Based on the performed simulations, it was found that in the frequency range above 10 MHz, the dependence of resistance and impedance on frequency is a power function with an exponent independent of the path width. Moreover, it was found that for paths with a width at least several times greater than their thickness, the dependence of the phase shift between current and voltage on frequency practically does not depend on the path width.
Multiple Access for Heterogeneous Wireless Networks with Imperfect Channels Based on Deep Reinforcement Learning
Authors: Xu Yangzhou , Lou Jia , Wang Tiantian , Shi Junxiao , Zhang Tao , Paul Agyemang , Wu Zhefu
Published: November 2023

In heterogeneous wireless networks, when multiple nodes need to share the same wireless channel, they face the issue of multiple access, which necessitates a Medium Access Control (MAC) protocol to coordinate the data transmission of multiple nodes on the shared communication channel. This paper presents Proximal Policy Optimization-based Multiple Access (PPOMA), a novel multiple access protocol for heterogeneous wireless networks based on the Proximal Policy Optimization (PPO) algorithm from deep reinforcement learning (DRL). Specifically, we explore a network scenario where multiple nodes employ different MAC protocols to access an Access Point (AP). The novel PPOMA approach, leveraging deep reinforcement learning, adapts dynamically to coexist with other nodes. Without prior knowledge, it learns an optimal channel access strategy, aiming to maximize overall network throughput. We conduct simulation analyses using PPOMA in two scenarios: perfect channel and imperfect channel. Experimental results demonstrate that our proposed PPOMA continuously learns and refines its channel access strategy, achieving an optimal performance level in both perfect and imperfect channel scenarios. Even when faced with suboptimal channel conditions, PPOMA outperforms alternative methods by achieving higher overall network throughput and faster convergence rates. In a perfect channel scenario, PPOMA’s advantage over other algorithms is primarily evident in its convergence speed, reaching convergence on average 500 iterations faster. In an imperfect channel scenario, PPOMA’s advantage is mainly reflected in its higher overall network throughput, with an approximate increase of 0.04.
Practical and Malicious Multiparty Private Set Intersection for Small Sets
Authors: Zhou Ji , Liu Zhusen , Wang Luyao , Zhao Chuan , Liu Zhe , Zhou Lu
Published: November 2023

Private set intersection (PSI) is a pivotal subject in the realm of privacy computation. Numerous research endeavors have concentrated on situations involving vast and imbalanced sets. Nevertheless, there is a scarcity of existing PSI protocols tailored for small sets. Those that exist are either restricted to interactions between two parties or necessitate resource-intensive homomorphic operations. To bring forth practical multiparty private set intersection solutions for small sets, we present two multiparty PSI protocols founded on the principles of Oblivious Key–Value Stores (OKVSs), polynomials, and gabled cuckoo tables. Our security analysis underscores the resilience of these protocols against malicious models and collision attacks. Through experimental evaluations, we establish that, in comparison to related endeavors, our protocols excel in small-set contexts, particularly in low-bandwidth wide area network (WAN) settings.
Vibration Signal Evaluation Based on K-Means Clustering as a Pre-Stage of Operational Modal Analysis for Structural Health Monitoring of Rotating Machines
Authors: Dreher Nathali Rolon , Storti Gustavo Chaves , Machado Tiago Henrique
Published: November 2023

Rotating machines are key components in energy generation processes, and faults can lead to shutdowns or catastrophes encompassing economic and social losses. Structural Health Monitoring (SHM) of structures in operation is successfully performed via Operational Modal Analysis (OMA), which has advantages over traditional methods. In OMA, white noise inputs lead to the accurate extraction of modal parameters without taking the system out of operation. However, this excitation condition is not easy to attain for rotating machines used in power generation, and OMA can provide inaccurate information. This research investigates the applicability of machine learning as a pre-stage of OMA to differentiate adequate from inadequate excitations and prevent inaccurate extraction of modal parameters. Data from a rotor system was collected under different conditions and OMA was applied. In a training stage, measurements were characterized by statistical features and K-means was used to determine which features provided information about the excitation condition, that is, which excitation was adequate to extract the rotor’s modal parameters via OMA. In a testing stage, data were successfully classified as adequate or not adequate for OMA, achieving 100% accuracy and revealing the technique’s potential to support SHM of rotating machines. The technique is extendable to other monitoring systems based on OMA.
Polymer Poly (Ethylene Oxide) Additive for High-Stability All-Inorganic CsPbI3−xBrx Perovskite Solar Cells
Authors: Chen Chun-Yang , Zhang Fang-Hui , Huang Jin , Xue Tao , Wang Xiao , Zheng Chao-Fan , Wang Hao , Jia Chun-Liang
Published: November 2023

All-inorganic CsPbI3−xBrx perovskite solar cells (PSCs) are becoming increasingly mature due to their excellent optoelectronic properties. However, because of the poor environmental stability of the perovskite material, the device is susceptibly decomposed when exposed to moisture, high temperature, and high illumination. Therefore, a critical task is to address the problem of poor long-term stability in the environment, which serves as a significant obstacle impeding the commercialization of perovskite solar cells. This article introduces the incorporation of PEO into all-inorganic CsPbI3−xBrx perovskites with an advantageous thermal stability. PEO acts as a passivating agent near the grain boundary, and its high viscosity characteristics effectively improve the film-forming properties, leading to a substantial reduction in defects and to improving the surface uniformity. In addition, the grain boundaries that serve as water and oxygen penetration channels are filled, resulting in a substantial improvement in device stability. With 7.5 mg/mL PEO doping into CsPbI3−xBrx, the unencapsulated device maintained its original power conversion efficiency of 98% after being placed in a dark environment of 40% humidity and 25 °C for 10 days. Using PEO effectively enhanced the performance of the devices, with the highest PCE reaching 10.95%, significantly improving environmental stability.
An Innovative and Environmentally Friendly System for Moving and Stabilising a Floating Dock in Position during Docking Operations
Authors: Szelangiewicz Tadeusz , Żelazny Katarzyna , Sobków Szymon
Published: November 2023

The study is aimed at designing a system which ensures dock mobility (moving from the quay to the dock trench) and stabilises the dock in position during docking operations. A number of requirements and design criteria have been defined for the dock moving system, the most important of them being its capability to support docking operations at a maximum wind force of 5 °B, and environmental friendliness (zero exhaust fumes or other pollutants). As part of the research, concepts for various dock moving systems have been developed, including calculations of technical and operational parameters. Each concept has been analysed for meeting the defined requirements and design criteria. Ultimately, a system which meets all of the requirements and criteria and is completely environmentally friendly has been selected for construction. The authors discuss the entire process of creating system concepts, parameter calculations, and assessment of fulfilment of the requirements and design criteria. The principle of operation and the design of the system have been explained. The dock is powered by electricity stored in batteries and generated from renewable energy sources.
Pandemic Economic Crises
Authors: Kalamen Kristián , Pollák František , Markovič Peter
Published: November 2023

The market serves as the convergence point of supply and demand and represents the process through which market relations between economic units materialize. From a global perspective, the focus shifts to the world market, which is the fundamental structure on which the global economy is based. The world economy operates as a very complex ecosystem. When it is exposed to the extremely damaging effects of a global pandemic, the term of a pandemic economic crisis becomes relevant.
Characterization and Yield of Eucalyptus regnans F. Muell Logs for Lumber Production
Authors: Rozas Carlos , Zapata Barbara , Muñoz Fernando , Ortiz-Araya Virna , Erazo Oswaldo
Published: November 2023

The yield of Eucalyptus regnans logs for lumber production was evaluated. Crack width and length at each log end were measured. Two log-cutting plans were used to obtain sawn lumber. The first plan (PA) considered logs with diameters varying from 28 to 40 cm, and in the second plan (PB), the log diameters ranged from 42 to 56 cm (PB). Lumber yield was determined using two log volume methods: the Japanese Agricultural Standards (JAS) and Smalian’s equation. The deformations of E. regnans lumber were measured. The Australian and Chilean standards were used to classify sawn lumber. The results showed that logs had radial cracks at both log ends. Cracks were classified into two groups, considering the crack length. Regarding the lumber deformations, most boards exhibited level B bows and crooks in both cutting plans. Levels A and B twists were prevalent in PA, whereas in PB, level A significantly outnumbered level B. The lumber yield of E. regnans in PB was higher than in PA. The lumber yield determined by Smalian’s equation was higher than that determined by the JAS method. This research provides insight into the characterization of E. regnans for lumber production, highlighting its relevance in the forestry industry.
Gender Justice and Feminist Politics: Decolonizing Collaborative Research
Authors: Figueroa Romero Dolores
Published: November 2023

The most prominent social effects of the drug war in Mexico are the criminalization of poverty and increased rates of feminicide. Feminist academics and community leaders have been developing and working hand in hand to find the most appropriate methods to document gender-based violence and feminicide to shed light on the impunity that hides the systemic dismissal of women’s lives. This essay presents a critical analysis of my own positionality as a feminist and academic ally in building a collaborative research alliance with indigenous women leaders who are politically engaged in the production of knowledge from an intersectional perspective that adequately reflects the matrix of violence that affects the lives of indigenous women in urban and rural areas. This process has been fruitful and promising, although it has also entailed challenges and contradictions arising from disparate meanings of gender justice and the lack of encounter of feminist/indigenous politics of resistance.
Effect of Exercise Training on Lipoprotein Subclass Particle Concentrations and Sizes in Older Women: Results from a Randomized Controlled Trial
Authors: Porter Ryan R. , Sparks Joshua R. , Durstine J. Larry , Custer Sabra S. , Thompson Raymond W. , Wang Xuewen
Published: November 2023

Background: Evidence suggests that lipoprotein subclass particles are critical markers of cardiovascular disease (CVD) risk. Older women have increased CVD risk related to age. The purpose of this study was to determine whether low and moderate doses of exercise influence lipoprotein subclasses. Methods: Women (60–75 years) were randomized into groups for 16 weeks of moderate-intensity exercise training at a low or moderate dose (33.6 and 58.8 kJ/kg body weight weekly, respectively). Lipoprotein subclasses were determined by nuclear magnetic resonance spectroscopy before and after the training. RESULTS: The average weekly exercise duration was 109 and 164 min, for low- and moderate-dose groups, respectively. In the low-dose group, high-density lipoprotein particle (HDL-P) concentration decreased (Δ = −1.9 ± 3.1 µmol/L, mean ± SD, p = 0.002) and mean HDL-P size increased (Δ = 0.1 ± 0.3 nm, p = 0.028). In the moderate-dose group, mean HDL-P size (Δ = 0.1 ± 0.2 nm; p = 0.024) and low-density lipoprotein particle size increased (Δ = 0.4 ± 3.9 nm; p = 0.007). Baseline body mass index, peak oxygen consumption and age were associated with changes in a few lipoprotein subclasses. Conclusions: In this sample of inactive older women, moderate-intensity exercise training at a dose equivalent to or even lower than the minimally recommended level by public health agencies induced changes in lipoprotein subclasses in line with reduced CVD risk. However, higher doses are encouraged for greater health benefits.
Technical and Economic Viability of Underground Hydrogen Storage
Authors: Quintos Fuentes José Ernesto , Santos Diogo M. F.
Published: November 2023

Considering the mismatch between the renewable source availability and energy demand, energy storage is increasingly vital for achieving a net-zero future. The daily/seasonal disparities produce a surplus of energy at specific moments. The question is how can this “excess” energy be stored? One promising solution is hydrogen. Conventional hydrogen storage relies on manufactured vessels. However, scaling the technology requires larger volumes to satisfy peak demands, enhance the reliability of renewable energies, and increase hydrogen reserves for future technology and infrastructure development. The optimal solution may involve leveraging the large volumes of underground reservoirs, like salt caverns and aquifers, while minimizing the surface area usage and avoiding the manufacturing and safety issues inherent to traditional methods. There is a clear literature gap regarding the critical aspects of underground hydrogen storage (UHS) technology. Thus, a comprehensive review of the latest developments is needed to identify these gaps and guide further R&D on the topic. This work provides a better understanding of the current situation of UHS and its future challenges. It reviews the literature published on UHS, evaluates the progress in the last decades, and discusses ongoing and carried-out projects, suggesting that the technology is technically and economically ready for today’s needs.
Pyrrolizidine Alkaloids—Pros and Cons for Pharmaceutical and Medical Applications
Authors: Jayawickreme Kavindi , Świstak Dawid , Ozimek Ewa , Reszczyńska Emilia , Rysiak Anna , Makuch-Kocka Anna , Hanaka Agnieszka
Published: November 2023

Heterocyclic organic compounds named pyrrolizidine alkaloids (PAs) belong to a group of alkaloids and are synthesized by either plants or microorganisms. Therefore, they are naturally occurring secondary metabolites. They are found in species applied in the pharmaceutical and food industries, thus a thorough knowledge of their pharmacological properties and toxicology to humans is of great importance for their further safe employment. This review is original because it synthesizes knowledge of plant and microbial PAs, which is unusual in the scientific literature. We have focused on the Boraginaceae family, which is unique due to the exceptional richness and diversity of its PAs in plant species. We have also presented the microbial sources of PAs, both from fungi and bacteria. The structure and metabolism of PAs have been discussed. Our main aim was to summarize the effects of PAs on humans, including both negative, toxic ones, mainly concerning hepatotoxicity and carcinogenicity, as well as potentially positive ones for pharmacological and medical applications. We have collected the results of studies on the anticancer activity of PAs from plant and microbial sources (mainly Streptomyces strains) and on the antimicrobial activity of PAs on different strains of microorganisms (bacteria and fungi). Finally, we have suggested potential applications and future perspectives.
Transcriptome and Metabolome Analyses Reveal Sugar and Acid Accumulation during Apricot Fruit Development
Authors: Gou Ningning , Chen Chen , Huang Mengzhen , Zhang Yujing , Bai Haikun , Li Hui , Wang Lin , Wuyun Tana
Published: November 2023

The apricot (Prunus armeniaca L.) is a fruit that belongs to the Rosaceae family; it has a unique flavor and is of important economic and nutritional value. The composition and content of soluble sugars and organic acids in fruit are key factors in determining the flavor quality. However, the molecular mechanism of sugar and acid accumulation in apricots remains unclear. We measured sucrose, fructose, glucose, sorbitol, starch, malate, citric acid, titratable acid, and pH, and investigated the transcriptome profiles of three apricots (the high-sugar cultivar ‘Shushanggan’, common-sugar cultivar ‘Sungold’, and low-sugar cultivar ‘F43’) at three distinct developmental phases. The findings indicated that ‘Shushanggan’ accumulates a greater amount of sucrose, glucose, fructose, and sorbitol, and less citric acid and titratable acid, resulting in a better flavor; ‘Sungold’ mainly accumulates more sucrose and less citric acid and starch for the second flavor; and ‘F43’ mainly accumulates more titratable acid, citric acid, and starch for a lesser degree of sweetness. We investigated the DEGs associated with the starch and sucrose metabolism pathways, citrate cycle pathway, glycolysis pathway, and a handful of sugar transporter proteins, which were considered to be important regulators of sugar and acid accumulation. Additionally, an analysis of the co-expression network of weighted genes unveiled a robust correlation between the brown module and sucrose, glucose, and fructose, with VIP being identified as a hub gene that interacted with four sugar transporter proteins (SLC35B3, SLC32A, SLC2A8, and SLC2A13), as well as three structural genes for sugar and acid metabolism (MUR3, E3.2.1.67, and CSLD). Furthermore, we found some lncRNAs and miRNAs that regulate these genes. Our findings provide clues to the functional genes related to sugar metabolism, and lay the foundation for the selection and cultivation of high-sugar apricots in the future.
From Cardiovascular Prevention and Differential Diagnosis to the Treatment of Myocardial Damage—Experimental and Human Perspectives
Authors: Pitha Jan
Published: November 2023

Cardiovascular diseases are characterized by many clinical, morphological, functional, and biochemical markers, including age, sex, genetic factors, plasma lipids, glycemia, and many other laboratory parameters [...]
Infrared Spectroscopy: A New Frontier in Hematological Disease Diagnosis
Authors: Delrue Charlotte , Speeckaert Reinhart , Oyaert Matthijs , Kerre Tessa , Rottey Sylvie , Coopman Renaat , Huvenne Wouter , De Bruyne Sander , Speeckaert Marijn M.
Published: November 2023

Hematological diseases, due to their complex nature and diverse manifestations, pose significant diagnostic challenges in healthcare. The pressing need for early and accurate diagnosis has driven the exploration of novel diagnostic techniques. Infrared (IR) spectroscopy, renowned for its noninvasive, rapid, and cost-effective characteristics, has emerged as a promising adjunct in hematological diagnostics. This review delves into the transformative role of IR spectroscopy and highlights its applications in detecting and diagnosing various blood-related ailments. We discuss groundbreaking research findings and real-world applications while providing a balanced view of the potential and limitations of the technique. By integrating advanced technology with clinical needs, we offer insights into how IR spectroscopy may herald a new era of hematological disease diagnosis.
Expression of Tumor Suppressor FHIT Is Regulated by the LINC00173-SNAIL Axis in Human Lung Adenocarcinoma
Authors: Suzuki Takahito , Sakai Satoshi , Ota Kosuke , Yoshida Mika , Uchida Chiharu , Niida Hiroyuki , Suda Takafumi , Kitagawa Masatoshi , Ohhata Tatsuya
Published: November 2023

Long non-coding RNAs (lncRNAs) play a critical role in a variety of human diseases such as cancer. Here, to elucidate a novel function of a lncRNA called LINC00173, we investigated its binding partner, target gene, and its regulatory mechanism in lung adenocarcinoma, including the A549 cell line and patients. In the A549 cell line, RNA immunoprecipitation (RIP) assays revealed that LINC00173 efficiently binds to SNAIL. RNA-seq and RT-qPCR analyses revealed that the expression of FHIT was decreased upon LINC00173 depletion, indicating that FHIT is a target gene of LINC00173. Overexpression of SNAIL suppressed and depletion of SNAIL increased the expression of FHIT, indicating that SNAIL negatively regulates FHIT. The downregulation of FHIT expression upon LINC00173 depletion was restored by additional SNAIL depletion, revealing a LINC00173-SNAIL-FHIT axis for FHIT regulation. Data from 501 patients with lung adenocarcinoma also support the existence of a LINC00173-SNAIL-FHIT axis, as FHIT expression correlated positively with LINC00173 (p = 1.75 × 10−6) and negatively with SNAIL (p = 7.00 × 10−5). Taken together, we propose that LINC00173 positively regulates FHIT gene expression by binding to SNAIL and inhibiting its function in human lung adenocarcinoma. Thus, this study sheds light on the LINC00173-SNAIL-FHIT axis, which may be a key mechanism for carcinogenesis and progression in human lung adenocarcinoma.
In Vitro and In Vivo Antimicrobial Activities of Vancomycin and Rifampin against Elizabethkingia anophelis
Authors: Lin I-Fan , Lai Chung-Hsu , Lin Shang-Yi , Lee Ching-Chi , Lee Nan-Yao , Liu Po-Yu , Yang Chih-Hui , Huang Yi-Han , Lin Jiun-Nong
Published: November 2023

Elizabethkingia anophelis has emerged as a critical human pathogen, and a number of isolated reports have described the successful treatment of Elizabethkingia infections with vancomycin, a drug that is typically used to target Gram-positive bacteria. This study employed in vitro broth microdilution checkerboard and time-kill assays, as well as in vivo zebrafish animal models to evaluate the individual and combination antimicrobial effects of vancomycin and rifampin against E. anophelis. The minimum inhibitory concentration ranges of vancomycin and rifampin against 167 isolates of E. anophelis were 16–256 mg/L and 0.06–128 mg/L, respectively. The checkerboard assay results revealed a synergistic effect between vancomycin and rifampin in 16.8% (28/167) of the isolates. Time-kill assays were implemented for 66 isolates, and the two-drug combination had a synergistic interaction in 57 (86.4%) isolates. In vivo zebrafish studies revealed that treatment with vancomycin monotherapy, rifampin monotherapy, or vancomycin–rifampin combination therapy yielded a higher survival rate than the control group treatment with 0.9% saline. The results of this study support the use of vancomycin to treat E. anophelis infections.
Lanthanide Contraction in LnF3 (Ln = Ce-Lu) and Its Chemical and Structural Consequences: Part 1: Location of YF3 in the LnF3 Series According to Its Chemical and Structural Characteristics
Authors: Sobolev Boris P. , Sulyanova Elena A.
Published: November 2023

A lanthanide contraction(LC) of 14 lanthanides (Ln) from 58Ce to 71Lu consists of the interaction of Ln nucleus with 4f-electrons. Rare earth elements (REEs—R) include Sc, Y, La, and 14 Ln. They are located in 4–6th periods of the subgroup of group III. The electronic structure divides R into short (d- Sc, Y, La) and long (14 f-elements Ce-Lu) homologous series. The most important chemical consequence of LC is the creation of a new conglomerate of 16 RF3 by mixing fluorides of d- (Y, La) and f-elements. This determines the location of YF3 among LnF3. The location of YF3 depends on the structural (formula volumes—Vform) and thermochemical (temperatures and heats of phase transformations, phase diagrams) properties. The location of YF3 between HoF3 and ErF3 was determined by Vform at a standard pressure (Pst) and temperature (Tst). The location of YF3 according to heats of phase transformations ΔHfus and ΔHtrans is in a dimorphic structural subgroup (SSGr) D (Ln = Er-Lu), but without the exact “pseudo ZY”. According to the temperatures of phase transformations (Ttrans) in LnF3 (Ln = Dy-Lu), YF3 is located in the SSGr D between ErF3 and TmF3. The ErF3-YF3 and YF3-TmF3 phase diagrams show it to be between ErF3 and TmF3. The crystals of five β-LnF3 (Ln = Ho-Lu) and β-YF3 were obtained in identical conditions and their crystal structures were studied. Vform (at Pst and Tst) with “pseudo” atomic number ZY = 67.42 was calculated from the unit cell parameters, which were defined with ±5 × 10−4 Å accuracy. It determines the location of YF3 between HoF3 and ErF3.
Loss of Foreign DNA Inserts from Barley Stripe Mosaic Virus Vectors—Potential Consequences for Use in Functional Genomics Studies
Authors: Scofield Steven R.
Published: November 2023

Barley stripe mosaic virus (BSMV)-based vectors are frequently used in virus-induced gene silencing (VIGS) and, more recently, viral overexpression (VOX) studies in wheat. Two general strategies are employed to initiate infection in wheat plants with BSMV in VIGS and VOX studies. One method involves the direct infection of wheat using viral RNA produced via the in vitro transcription of BSMV constructs. The second class utilizes viral replication in an intermediate host plant to produce large amounts of BSMV viral particles that are then used to inoculate wheat plants. This study was designed to examine the potential for BSMV-VIGS constructs to rearrange during replication in the intermediate host and result in initiating the VIGS studies with a virus that is significantly different from the original experimental construct. It is shown that in the case of BSMV-VIGS constructs harboring a PDS-silencing fragment, significant rearrangement can occur during replication in the intermediate host that has the potential to introduce artifactual experimental outcomes.
Tropicohilara, a New Genus of Hilarini (Diptera: Empididae: Empidinae) from Brazil, with Descriptions of Six New Species
Authors: Marques Dayse W. A. , Daugeron Christophe , Rafael José Albertino
Published: November 2023

The genus Tropicohilara gen. nov. (Diptera: Empididae: Empidinae: Hilarini) is described and includes the following six new species from Brazil: Tropicohilara amazonensis sp. nov. (type species, Brazil: Amazonas, Manaus); T. bahiensis sp. nov. (Brazil: Bahia, Camacan); T. bella sp. nov. (Brazil: Pernambuco, Jaqueira); T. mineira sp. nov. (Brazil: Minas Gerais, Itamonte); T. paranaensis sp. nov. (Brazil: Paraná, Piraquara); and T. sinclairi sp. nov. (Brazil: Paraná, Morretes). The genus is presently recorded from the Amazonian and Atlantic Forest biomes. It differs from other hilarine genera by the following combination of characteristics: predominantly yellowish specimens; occiput somewhat conical in dorsal view; postpedicel elongate, male first fore tarsomere unmodified; hind tibia slightly shorter than hind femur; wing vein R2+3 with setae on ventral surface; male tergite 7 with a sclerotized band at posterior margin, tergite 8 reduced and upwardly directed so that terminalia can be flexed forward. A key to the species is provided.
What We Should Expect from an Innovative Intra-Articular Hyaluronic Acid Product: Expert Opinion Based on a Comprehensive Review of the Literature
Authors: Migliore Alberto , Maheu Emmanuel , Saccone Luca , de Campos Gustavo C. , Alekseeva Lyudmila , Chevalier Xavier , Conrozier Thierry , Crimaldi Sergio , Diracoglu Demirhan , Herrero-Beaumont Gabriel , Iolascon Giovanni , Ionescu Ruxandra , Jerosch Jörg , Laíns Jorge , Makri Souzi , Martusevich Natalia , Matucci Cerinic Marco , Pavelka Karel , J. Petrella Robert , Tarantino Umberto , R. Bannuru Raveendhara
Published: November 2023

Background: Intra-articular hyaluronic acid (IAHA) products are often used in the treatment of adults with mild-to-moderate knee osteoarthritis (KOA). The International Symposium on Intra-Articular Treatment (ISIAT) convened a multidisciplinary technical expert panel to define characteristics for an innovative IAHA product that should answer unmet needs in the clinical management of adults with mild-to-moderate KOA. Methods: An initial set of evidence-based statements was developed based on data extracted from articles identified through a comprehensive literature search. A Delphi panel comprising 19 experts in KOA voted in 3 rounds to rate their degree of agreement with accepted statements. Results: The final set of 13 accepted statements focus on the effect of an innovative IAHA across 5 key domains of nociceptive pain, joint function, quality of life, joint structure and integrity, and adverse effects. The statements set thresholds for clinically meaningful improvements that exceed those generally achievable by currently available IAHA products. Conclusion: The characteristics described by these statements from the ISIAT set new standards for what should be expected from an innovative IAHA. These statements should serve as a framework for driving the development of innovative IAHA products that will surpass the actual outcomes achieved by current viscosupplements in patients with mild-to-moderate KOA.
Predicting In-Hospital Acute Heart Failure Worsening in the Oldest Old: Insights from Point-of-Care Ultrasound
Authors: Mazzarone Tessa , Morelli Virginia , Giusti Andrea , Bianco Maria Giovanna , Maccioni Lorenzo , Cargiolli Cristina , Guarino Daniela , Virdis Agostino , Okoye Chukwuma
Published: November 2023

The decompensation trajectory check is a basic step to assess the clinical course and to plan future therapy in hospitalized patients with acute decompensated heart failure (ADHF). Due to the atypical presentation and clinical complexity, trajectory checks can be challenging in older patients with acute HF. Point-of-care ultrasound (POCUS) has proved to be helpful in the clinical decision-making of patients with dyspnea; however, to date, no study has attempted to verify its role in predicting determinants of ADHF in-hospital worsening. In this single-center, cross-sectional study, we consecutively enrolled patients aged 75 or older hospitalized with ADHF in a tertiary care hospital. All of the patients underwent a complete clinical examination, blood tests, and POCUS, including Lung Ultrasound and Focused Cardiac Ultrasound. Out of 184 patients hospitalized with ADHF, 60 experienced ADHF in-hospital worsening. By multivariable logistic analysis, total Pleural Effusion Score (PEFs) [aO.R.: 1.15 (CI95% 1.02–1.33), p = 0.043] and IVC collapsibility [aO.R.: 0.90 (CI95% 0.83–0.95), p = 0.039] emerged as independent predictors of acute HF worsening after extensive adjustment for potential confounders. In conclusion, POCUS holds promise for enhancing risk assessment, tailoring diuretic treatment, and optimizing discharge timing for older patients with ADHF.
Evolution of More Aggressive LDL-Cholesterol Targets and Therapies for Cardiovascular Disease Prevention
Authors: Jones Jeffrey , Tang Kevin , Barseghian Ailin , Wong Nathan
Published: November 2023

Over the last half-century, discussions on the exact targets for low-density lipoprotein cholesterol (LDL-C) reduction have evolved towards a more aggressive approach with lower LDL-C targets, particularly for high-risk patients with pre-existing atherosclerotic cardiovascular disease (ASCVD). A wealth of cardiovascular outcome trials have shown the efficacy of statin therapy in general, as well as the incremental impact of high-intensity statin therapy in particular. More recent trials have further demonstrated the impact of non-statin therapies, including ezetimibe, proprotein convertase subtilisin/kexin type 9 inhibitors, and, most recently, bempedoic acid, on reducing ASCVD outcomes. The availability of these and other newer therapies has prompted clinicians to strive for lower LDL-C targets to address residual ASCVD risk after statin therapy. This paper will provide an overview of the historical trends in lipid management and therapeutics and review the current state of evidence for lower LDL-C targets in clinical guidelines and recommendations.
Implant Preference and Clinical Outcomes of Patients with Staged Bilateral Total Knee Arthroplasty: All-Polyethylene and Contralateral Metal-Backed Tibial Components
Authors: Nachtnebl Luboš , Apostolopoulos Vasileios , Mahdal Michal , Pazourek Lukáš , Brančík Pavel , Valoušek Tomáš , Boháč Petr , Tomáš Tomáš
Published: November 2023

Numerous studies have compared metal-backed components (MBTs) and all-polyethylene tibial components (APTs), but none of them specifically analysed the clinical results and the overall patient preference in patients who had undergone a staged bilateral knee replacement. The purpose of this study is to compare clinical results, perceived range of motion, and overall implant preference among patients who had undergone staged bilateral knee replacement with an APT and contralateral knee replacement with MBTs. A dataset of 62 patients from a single centre who underwent staged bilateral TKA between 2009 and 2022 was selected and retrospectively analysed. Tibial component removal was performed in three knees overall, all of which had MBTs. The mean measured Knee Score (KS) of knees with APTs was 78.37 and that of contralateral knees with MBTs was 77.4. The mean measured Function (FS) of knees with APTs was 78.22, and that of contralateral knees with MBs was 76.29. The mean flexion angle of knees with APTs was 103.8 and that for knees with MBTs was 101.04 degrees. A total of 54.8% of the patients preferred the knee that received APTs over contralateral MBTs. In our cohort, TKA with an APT in one knee and an MBT in the contralateral knee recorded similar clinical results and perceived ranges of motion. Patients in general preferred the knee that received an APT over contralateral knee with an MBT.
Comparison of Intravenous Acetaminophen and Intravenous Patient-Controlled Analgesia Fentanyl after Total Hip Arthroplasty: A Multicenter Randomized Controlled Trial
Authors: Sakai Yoshinori , Imai Norio , Miyasaka Dai , Suzuki Hayato , Horigome Yoji , Takahashi Yasuhito , Kawashima Hiroyuki
Published: November 2023

Background: Opioids often need to be discontinued because they cause nausea, whereas the administration of intravenous acetaminophen (APAP) causes less nausea and vomiting. This study aimed to compare the effects of fentanyl-based intravenous patient-controlled analgesia (IV-PCA) and intravenous APAP on pain and nausea after total hip arthroplasty (THA). Methods: We prospectively investigated primary THA patients who underwent the anterolateral supine approach at four centers between October 2021 and October 2022. The patients (n = 178) were divided randomly into IV-PCA (n = 88) and APAP groups (n = 90). Rest pain, motion pain, and nausea were assessed using NRS scores. Results: Compared with the APAP group, the IV-PCA group experienced significantly greater resting pain and nausea on postoperative day 1. A correlation was found between preoperative and postoperative pain. Postoperative nausea at 8 h was significantly correlated with pain at rest at 4 h (r = 0.193), 8 h (r = 0.194), day 1 (r = 0.245), and day 2 (r = 0.188) after surgery. Early postoperative pain and nausea correlated with subsequent pain and nausea. Conclusions: Intravenous APAP is associated with less pain and nausea and is superior to IV-PCA.
The Kneeling Isometric Plantar Flexor Test: Preliminary Reliability and Feasibility in Professional Youth Football
Authors: McMahon John J. , Ripley Nicholas J. , Comfort Paul , Robles-Palazón Francisco Javier , Fahey Jack T. , Badby Andrew J. , Bramah Christopher
Published: November 2023

Calf injuries are common in professional football; thus, the establishment of reliable and time-efficient methods of measuring the peak force capabilities of the plantar flexors with equipment that is accessible to football practitioners is valuable. In this study, we determined the preliminary reliability and feasibility of a new test, termed the kneeling isometric plantar flexion test (KIPFT), for footballers. Twenty-one male youth footballers (age = 17.8 ± 1.1 years, height = 182 ± 5 cm, weight = 77.6 ± 5.9 kg) from English League One football clubs completed three trials of the KIPFT on a wireless force plate at the end (2022–2023) and start (2023–2024) of the season. The within-session reliability of the peak force (relative to body weight) was good–excellent for both limbs and both occasions. On average, performance of the KIPFT took just over 1 min per limb and ~2 min to set up. The peak force values were larger for the non-dominant limbs only at the start versus the end of the season, but there were no between-limb differences. From these results, it was determined that (1) the KIPFT is feasible, (2) a minimum of 32 footballers would be required to establish its between-session reliability with ≥80% statistical power and (3) large-cohort normative data for the KIPFT may be best collected at the start of the football season.
A Novel Multi–Scale One–Dimensional Convolutional Neural Network for Intelligent Fault Diagnosis of Centrifugal Pumps
Authors: Geng Yunhan , Su Shaojuan , Zhang Tianxiang , Zhu Zhaoyu
Published: November 2023

Centrifugal pumps are susceptible to various faults, particularly under challenging conditions such as high pressure. Swift and accurate fault diagnosis is crucial for enhancing the reliability and safety of mechanical equipment. However, monitoring data under fault conditions in centrifugal pumps are limited. This study employed an experimental approach to gather original monitoring data (vibration signal data) across various fault types. We introduce a multi–scale sensing Convolutional Neural Network (MS–1D–CNN) model for diagnosing faults in centrifugal pumps. The network structure is further optimized by examining the impact of various hyperparameters on its performance. Subsequently, the model’s efficacy in diagnosing centrifugal pump faults has been comprehensively validated using experimental data. The results demonstrate that, under both single and multiple operating conditions, the model not only reduces reliance on manual intervention but also improves the accuracy of fault diagnosis.
The Role of Interleukins in HBV Infection: A Narrative Review
Authors: Dimitriadis Konstantinos , Katelani Stamatia , Pappa Maria , Fragkoulis George E. , Androutsakos Theodoros
Published: November 2023

Hepatitis B virus (HBV) infection is a worldwide medical issue with significant morbidity and mortality, as it is the main cause of chronic liver disease and hepatocellular carcinoma (HCC). Both innate and adaptive immune responses play a key role in HBV replication and suppression. Recently, the pathophysiological function of interleukins (IL) in the natural course of HBV has gained much attention as a result of the broad use of anti-interleukin agents for a variety of autoimmune diseases and the accompanying risk of HBV reactivation. We present a narrative review regarding the role of IL in HBV infection. Collectively, the pro-inflammatory ILs, namely IL-1, IL-5, IL-6, IL-12 and IL-21, seem to play a critical role in the suppression of HBV replication. In contrast, the anti-inflammatory cytokines IL-10, IL-23 and IL-35 probably act as HBV replication enhancers, while IL-17 has been correlated with HBV-related liver injury. Interestingly enough, IL-2, IL-4 and IL-12 have been tried as therapeutic options against HBV infection with contradictory results. Lastly, the role of IL-22 remains largely ill defined, although preliminary data suggest that it may play a significant role in HBV replication, proliferation and subsequent liver damage.
Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP
Authors: Zaha Ioana Alexandra , Huniadi Anca , Bodog Florin , Seles Luana , Toma Mihaela Cristina , Maghiar Laura , Szulay-Bimbo Erika , Bodog Alin , Sachelarie Liliana , Florea Mihai , Stefan Liana
Published: November 2023

(1) Background: During IVF (in vitro fertilization) procedures, endometrial thickness has a significant role in the success of pregnancy outcomes for embryo transfers. Endometrial thickness, a crucial component of endometrial receptivity, is a contentious issue. The regenerative properties of PRP have been shown in recent research to have positive effects on the endometrium. PRP increases the pregnancy rate in IVF patients with thin endometrium and recurrent implantation failure. In order to demonstrate the efficacy of PRP therapies, this work compares the administration of injectable and infusible PRP during endometrial preparation. (2) Methods: This prospective single-arm control study was conducted at an IVF center in Oradea, Romania. This study included 50 patients; 27 were included in the group with Injectable PRP and 23 in the group with Infusible PRP. The outcome was compared between the two groups, with the primary outcome being the endometrial thickness after the PRP infusion or injection and the secondary outcome being the pregnancy rate in both groups. (3) Results: Patients who were treated with Injectable PRP had a higher pregnancy rate. An improvement in the quality of the endometrium, in terms of thickness, was also observed in the patients who were injected with PRP. (4) Conclusions: Compared to PRP infusions inside the uterus, sub-endometrial PRP injections in frozen embryo transfer methods have a greater pregnancy rate.
Host–Parasitoid Phenology, Distribution, and Biological Control under Climate Change
Authors: Ramos Aguila Luis Carlos , Li Xu , Akutse Komivi Senyo , Bamisile Bamisope Steve , Sánchez Moreano Jessica Paola , Lie Zhiyang , Liu Juxiu
Published: November 2023

Climate change raises a serious threat to global entomofauna—the foundation of many ecosystems—by threatening species preservation and the ecosystem services they provide. Already, changes in climate—warming—are causing (i) sharp phenological mismatches among host–parasitoid systems by reducing the window of host susceptibility, leading to early emergence of either the host or its associated parasitoid and affecting mismatched species’ fitness and abundance; (ii) shifting arthropods’ expansion range towards higher altitudes, and therefore migratory pest infestations are more likely; and (iii) reducing biological control effectiveness by natural enemies, leading to potential pest outbreaks. Here, we provided an overview of the warming consequences on biodiversity and functionality of agroecosystems, highlighting the vital role that phenology plays in ecology. Also, we discussed how phenological mismatches would affect biological control efficacy, since an accurate description of stage differentiation (metamorphosis) of a pest and its associated natural enemy is crucial in order to know the exact time of the host susceptibility/suitability or stage when the parasitoids are able to optimize their parasitization or performance. Campaigns regarding landscape structure/heterogeneity, reduction of pesticides, and modelling approaches are urgently needed in order to safeguard populations of natural enemies in a future warmer world.
Hot Tensile Deformation Mechanism and Fracture Behavior of the ZW31/PMMC Laminate
Authors: Fan Dingge , Wang Cuiju , Zhang Xuanchang , Nie Kaibo , Deng Kunkun
Published: November 2023

In this work, a Mg-Zn-Y (ZW31) alloy with good plasticity was introduced into 10 μm 10 vol% SiCp/AZ91 composite materials (PMMCs) via the extrusion compound method, and then the ZW31/PMMC laminate was prepared via multi-pass hot rolling. The hot deformation mechanism and elevated temperature tensile fracture mechanism of ZW31/PMMC laminates were studied using the elevated temperature tensile test. The elevated temperature deformation mechanism is influenced by the strain rate. At low strain rates, grain boundary slip is the primary elevated temperature deformation mechanism of the ZW31/PMMC laminate. However, at high strain rates, the activation of pipeline diffusion is facilitated by the particle deformation zone (PDZ) in the PMMC layer with a high dislocation density, leading to the dominance of dislocation climbing as the main mechanism for elevated temperature deformation of the laminate. Additionally, the implementation of a ZW31/PMMC laminate structure effectively inhibits the initiation and propagation of cavities and microcracks within the laminate layer along the normal direction (ND) while simultaneously blunting crack tips via lattice dislocation emission toward the ZW31 layer. Upon cracking of the PMMC layer, stress concentration occurs in the fracture area of the ZW31 layer, ultimately resulting in necking-induced detachment.
A Novel Physically Guided Data Fusion Prediction Model for Micro-EDM Drilling
Authors: Cheng Chen , Liu Beiying , Cheng Jinxin , Xiong Xiao
Published: November 2023

Accurate prediction of Electro-Discharge Machining (EDM) results is crucial for industrial applications, aiming to achieve high-performance and cost-efficient machining. However, both the current physical model and the standard Artificial Neural Network (ANN) model exhibit inherent limitations, failing to fully meet the accurate requirements for predicting EDM machining results. In addition, Micro-EDM Drilling can lead to the distortion of the macroscopic shape of machining pits under different input conditions, rendering the use of only the volume of machining pits as the evaluation index insufficient to express the complete morphological information. In this study, we propose a novel hybrid prediction model that combines the strengths of both physical and data-driven models to simultaneously predict Material Removal Rate (MRR) and shape parameters. Our experiment demonstrates that the hybrid model achieves a maximum prediction error of 4.92% for MRR and 5.28% for shape parameters, showcasing excellent prediction accuracy and stability compared to the physical model and the standard ANN model.