bluuebunny/crossref_metadata_2025 huggingface dataset:
Very early migration of a calcar-guided short stem: a randomized study of early mobilization and the influence of a calcium phosphate coating with 60 patients
Authors: Budde Stefan , Derksen Alexander , Hurschler Christof , Fennema Peter , Windhagen Henning , Plagge Jochen , Flörkemeier Thilo , von Lewinski Gabriela , Noll Yvonne , Schwarze Michael
Published: February 2024

This study analyzed the migration of a calcar-guided short stem to determine the course of very early migration, as well as evaluated the effect of an additional calcium phosphate (CP) coating on a titanium plasma spray (TPS) coating, which has not been analyzed previously. Sixty patients were enrolled in this study and were treated with the A2 calcar-guided short stem. The implant coating was randomized with either the TPS or an additional CP coating, and radiostereometric analysis was performed with the baseline measurement before initial weight-bearing, along with follow-up examinations at 1 week, 6 weeks, 3 months, and 6 months. Implant migrations were 0.27 mm (standard deviation [SD], 0.13 mm) and 0.74 mm (SD, 1.11 mm) at 1 week and 6 months post-surgery, respectively, and 65% and 87% of the implants reached their final position 1 week and 6 weeks after surgery, respectively. After 6 weeks, 3 months, and 6 months, a significant increase was noted in the migration of the CP coating group vs. that of the TPS coating group. Upon the final observation at 6 months, the groups displayed on average a 0.74-mm migration. Most of the analyzed implants ceased migration within the first week post-surgery, but the CP coating demonstrated a higher and more prolonged migration compared to the TPS coating.
Non-linear relationship between pulse pressure and the risk of prediabetes: a 5-year cohort study in Chinese adults
Authors: Huang Zhenhua , Wang Fangxi , Xiao Xiaoyong , Liu Dehong , Deng Zhe
Published: February 2024

Previous research has established a strong link between pulse pressure (PP) and diabetes, but there is limited investigation into the connection between PP and prediabetes. This study aims to explore the potential association between PP and prediabetes. A retrospective cohort study encompassed 202,320 Chinese adults who underwent health check-ups between 2010 and 2016. Prediabetes was defined in accordance with the World Health Organization criteria, indicating impaired fasting glucose, with fasting blood glucose levels ranging from 6.1 to 6.9 mmol/L. To assess the PP-prediabetes relationship, we employed Cox regression analysis, sensitivity analysis, and subgroup analysis. Cox proportional hazards regression, coupled with cubic spline functions and smooth curve fitting, helped elucidate the non-linear PP-prediabetes relationship. Upon adjusting for confounding factors, we observed a positive association between PP and prediabetes (HR 1.15, 95% CI 1.11–1.18, P < 0.0001). Participants in the fourth quartile (PP ≥ 51 mmHg) had a 73% higher likelihood of developing prediabetes compared to those in the first quartile (PP < 36 mmHg) (HR 1.73, 95% CI 1.52–1.97, P < 0.0001). Moreover, the relationship between PP and prediabetes was non-linear. A two-piece Cox proportional hazards regression model identified an inflection point at 40 mmHg for PP (P for log-likelihood ratio test = 0.047). Sensitivity and subgroup analyses corroborated the robustness of our findings. Our study reveals a non-linear correlation between PP and prediabetes, signifying an increased risk of prediabetes when PP levels exceed 40 mmHg. This discovery has significant clinical implications for early prediabetes prevention and intervention, ultimately contributing to improved patient outcomes and quality of life.
Association of plant-based dietary patterns with the risk of type 2 diabetes mellitus using cross-sectional results from RaNCD cohort
Authors: Heidarzadeh-Esfahani Neda , Darbandi Mitra , Khamoushi Firoozeh , Najafi Farid , Soleimani Davood , Moradi Mozhgan , Shakiba Ebrahim , Pasdar Yahya
Published: February 2024

The prevalence of type 2 diabetes mellitus (T2DM) is increasing in middle- and low-income countries, and this disease is a burden on public health systems. Notably, dietary components are crucial regulatory factors in T2DM. Plant-based dietary patterns and certain food groups, such as whole grains, legumes, nuts, vegetables, and fruits, are inversely correlated with diabetes incidence. We conducted the present study to determine the association between adherence to a plant-based diet and the risk of diabetes among adults. We conducted a cross-sectional, population-based RaNCD cohort study involving 3401 men and 3699 women. The plant-based diet index (PDI) was developed using a 118-item food frequency questionnaire (FFQ). Logistic regression models were used to evaluate the association between the PDI score and the risk of T2DM. A total of 7100 participants with a mean age of 45.96 ± 7.78 years were analysed. The mean PDI scores in the first, second, and third tertiles (T) were 47.13 ± 3.41, 54.44 ± 1.69, and 61.57 ± 3.24, respectively. A lower PDI was significantly correlated with a greater incidence of T2DM (T1 = 7.50%, T2 = 4.85%, T3 = 4.63%; P value < 0.001). Higher PDI scores were associated with significantly increased intakes of fibre, vegetables, fruits, olives, olive oil, legumes, soy products, tea/coffee, whole grains, nuts, vitamin E, vitamin C, and omega-6 fatty acids (P value < 0.001). After adjusting for confounding variables, the odds of having T2DM were significantly lower (by 30%) at T3 of the PDI than at T1 (OR = 0.70; 95% CI = 0.51, 0.96; P value < 0.001). Our data suggest that adhering to plant-based diets comprising whole grains, fruits, vegetables, nuts, legumes, vegetable oils, and tea/coffee can be recommended today to reduce the risk of T2DM.
A pan-influenza monoclonal antibody neutralizes H5 strains and prophylactically protects through intranasal administration
Authors: Beukenhorst Anna L. , Frallicciardi Jacopo , Rice Keira L. , Koldijk Martin H. , Moreira de Mello Joana C. , Klap Jaco M. , Hadjichrysanthou Christoforos , Koch Clarissa M. , da Costa Kelly A. S. , Temperton Nigel , de Jong Babette A. , Vietsch Helene , Ziere Bertjan , Julg Boris , Koudstaal Wouter , Goudsmit Jaap
Published: February 2024

Avian A(H5N1) influenza virus poses an elevated zoonotic threat to humans, and no pharmacological products are currently registered for fast-acting pre-exposure protection in case of spillover leading to a pandemic. Here, we show that an epitope on the stem domain of H5 hemagglutinin is highly conserved and that the human monoclonal antibody CR9114, targeting that epitope, potently neutralizes all pseudotyped H5 viruses tested, even in the rare case of substitutions in its epitope. Further, intranasal administration of CR9114 fully protects mice against A(H5N1) infection at low dosages, irrespective of pre-existing immunity conferred by the quadrivalent seasonal influenza vaccine. These data provide a proof-of-concept for broad, pre-exposure protection against a potential future pandemic using the intranasal administration route. Studies in humans should assess if autonomous administration of a broadly-neutralizing monoclonal antibody is safe and effective and can thus contribute to pandemic preparedness.
A hybridized red deer and rough set clinical information retrieval system for hepatitis B diagnosis
Authors: Mishra Madhusmita , Acharjya D. P.
Published: February 2024

Healthcare is a big concern in the current booming population. Many approaches for improving health are imposed, such as early disease identification, treatment, and prevention. Therefore, knowledge acquisition is highly essential at different stages of decision-making. Inferring knowledge from the information system, which necessitates multiple steps for extracting useful information, is one technique to address this problem. Handling uncertainty throughout data analysis is also another challenging task. Computer intelligence is a step forward to this end while selecting characteristics, classification, clustering, and developing clinical information retrieval systems. According to recent studies, swarm optimization is a useful technique for discovering key features while resolving real-world issues. However, it is ineffective in managing uncertainty. Conversely, a rough set helps a decision system generate decision rules. This produces decision rules without any additional information. In order to assess real-world information systems while managing uncertainties, a hybrid strategy that combines a rough set and red deer algorithm is presented in this research. In the red deer optimization algorithm, the suggested method selects the optimal characteristics in terms of the degree of dependence on the rough set. In order to determine the decision rules, further a rough set is used. The efficiency of the suggested model is also contrasted with that of the decision tree algorithm and the conventional rough set. An empirical study on hepatitis disease illustrates the viability of the proposed research as compared to the decision tree and crisp rough set. The proposed hybridization of rough set and red deer algorithm achieves an accuracy of 91.7% accuracy. The acquired accuracy for the decision tree, and rough set methods is 82.9%, and 88.9%, respectively. It suggests that the proposed research is viable.
Spatial quasi-bound states of Dirac electrons in graphene monolayer
Authors: Miniya Mohammed , Oubram Outmane , El Hachimi Abdel Ghafour , Gaggero-Sager Luis Manuel
Published: February 2024

Our study investigated the emergence of spatial quasi-bound states (QBSs) in graphene monolayers induced by rectangular potential barriers. By solving the time-independent Dirac equation and using the transfer matrix formalism, we calculated the resonance energies and identify the QBSs based on probability density functions (PDF). We analyzed two types of structures: single and double barriers, and we find that the QBSs are located within the barrier region, at energies higher than the single barrier. Additionally, we observe QBSs in the double barrier and their position depends on the distance and width of the well between the two barriers. The width and height of the barrier significantly impact the QBSs while the well width influences the resonance energy levels of the QBSs in the double barrier. Interestingly, the QBSs can be manipulated in the graphene system, offering potential for optoelectronic devices. Finally, our results demonstrated that the spatial localization of these states is counter-intuitive and holds great promise for future research in optolectronic devices.
Effects of landscape pattern on land surface temperature in Nanchang, China
Authors: Liu Pinyi , Liu Chunqing , Li Qingjie
Published: February 2024

The composition and configuration of landscapes are critical important to design effective approaches to mitigate urban thermal environment in the urbanization process. In this research, land use maps and land surface temperature (LST) retrieval were derived in Nanchang city of central China based on product datasets and the thermal infrared band of Landsat. The results showed that the thermal environment of Nanchang had become worse over the past two decades, that is, the proportion of area of the extremely low temperature zone (ELTZ) decreased from 4.39 to 0.77% from 2001 to 2020, and that of medium temperature zone (MTZ) reduced by 20%, whereas those of the high temperature zone (HTZ) and the extremely high temperature zone (EHTZ) increased sharply after 2001, and by 2020, the area ratio increased by 11% and 7.16%, respectively. The agricultural land (AL) area decreased from 68.44 to 49.69%, was gradually replaced by construction land (CL). The CL occupied the largest proportion in EHTZ, HTZ and slight high temperature zone (SHTZ); water landscape (WL) and green land (GL) occupied the largest proportion in ELTZ, low temperature zone (LTZ); and AL occupied the largest proportion in SHTZ, MTZ, and slight low temperature zone (SLTZ). Landscape configuration also obviously impacted on LST. The model fitting was well (R = 0.87) between land use area and LST by multiple regression analysis. The significant correlation between LST and six landscape pattern indices of CL (p < 0.01) indicated that the larger percent (PLANT, R = 0.78) and the more concentrate (LPI, R = 0.73) of CL implied the higher LST, while the more fragment (NP, R = − 0.45), dispersed and complex shape (R = − 0.35) were benefit to relieve LST. Contrastively, the larger percent and the more concentrated and complex shape distribution of AL, GL and WL, the lower LST (p < 0.01). In addition, LST had closely correlation with landscape level indices such as aggregation degree (AI, R = 0.44) and diversity (SHDI, R = − 0.60) (p < 0.01).
Dynamic person-position matching decision method based on hesitant fuzzy number information
Authors: Yue Qi , Liu Liezhang , Tao Yuan
Published: February 2024

In view of the fact that people pay more and more attention to the principle of "getting the position according to the person" and "adapting the person to the position" in person-position matching, a dynamic person-position matching decision method based on hesitant fuzzy numbers is proposed. First, the dynamic person-position matching problem with hesitant fuzzy numbers is described. Then, according to hesitant fuzzy evaluation matrices of positions and candidates, expected score matrices of bilateral subjects are calculated. Furthermore, based on the idea of the generalized optimal order method and the dominant correlation and the missing correlation coefficients, satisfaction means of people and positions are calculated. According to satisfaction means, growth satisfactions at each period are obtained, and then the exponential decay formula is used to determine weights of growth satisfactions. Dynamic satisfactions of bilateral subjects are calculated by aggregating initial satisfaction means and growth satisfactions. On this basis, a stable person-position matching model considering dynamic satisfactions is established and then is solved to obtain the optimal stable person-position matching scheme. Finally, the feasibility and effectiveness of the proposed method are verified by an example analysis of person-position matching. Main contributions of this paper are as follows: an effective calculation method for the missing correlation coefficient is presented; a novel effective calculation method for dynamic satisfactions is proposed by introducing the correlation parameter to combine the missing correlation coefficient with the dominant correlation coefficient; an effective stable person-position matching model considering dynamic satisfactions is established.
Cardiopulmonary exercise test combined with red blood cell distribution width to predict cardiovascular complication of thoracic surgery
Authors: Lin Quanqiang , Zhao Qingheng , Xiao Qiang , Li Yuanmin
Published: February 2024

Cardiovascular complications in patients undergoing thoracic surgery, which physicians have a limited ability to predict, are often unavoidable and resulting in adverse outcome. Cardiopulmonary exercise testing (CPET), the gold standard of cardiopulmonary function evaluation, has also been proved to be a preoperative risk assessment tool. Meanwhile, elevated red blood cell distribution width (RDW) has surged as a biochemical marker in the occurrence of cardiovascular disease. However, it is yet unclear the value of CPET combined with RDW in predicting cardiovascular complications after thoracic surgery. 50 patients with cardiovascular complications after thoracic surgery were collected as the case group, and 100 thoracic surgery patients were recruited as the control group, with the same gender, age ± 2 years old, and no postoperative complications. After admission, all patients underwent CPET and RDW inspection before surgery, and the results were recorded. The CPET parameter oxygen pulse (VO2/HR) and RDW of the case group were lower than those of the control group (P < 0.05), and the ventilation/carbon dioxide production (VE/VCO2 slope) was significantly higher than control group (P < 0.01). The biochemical parameters hemoglobin (Hb) and Glomerular filtration rate (GFR)) of the case group were lower than those of the control group (P < 0.05), the homocysteine (hCY), creatinine (Cr), operation time and blood loss of the case group were higher than those of the control group (P < 0.05). The RDW had a negative correlation with VO2 max in both overall and control group. The combination of VO2/kg and RDW had the highest diagnostic value in predicting cardiovascular complications. The combination of VO2/kg and RDW has predictive diagnostic value and is more suitable for predicting postoperative complications of thoracic surgery.
Differences in lobar microbleed topography in cerebral amyloid angiopathy and hypertensive arteriopathy
Authors: Kuo Pin-Yan , Tsai Hsin-Hsi , Lee Bo-Ching , Chiang Pu-Tien , Liu Chia-Ju , Chen Ya-Fang , Jeng Jiann-Shing , Yen Ruoh-Fang , Tsai Li-Kai
Published: February 2024

Lobar cerebral microbleeds are a characteristic neuroimaging finding in cerebral amyloid angiopathy (CAA) but can also be found in hypertensive arteriolosclerosis. We aimed to investigate whether CAA is more associated with intracortical lobar microbleeds than hypertensive arteriosclerosis. Ninety-one survivors of spontaneous intracerebral hemorrhage with at least one lobar microbleed were included and underwent brain MRI and amyloid PET. We categorized lobar microbleeds as intracortical, juxtacortical, or subcortical. We assessed the associations between the lobar microbleed categories and microangiopathy subtypes or cerebral amyloid load based on the Pittsburgh Compound-B PET standardized uptake value ratio (SUVR). Patients with CAA had a higher prevalence of intracortical lobar microbleeds (80.0% vs. 50.8%, P = 0.011) and lower prevalence of subcortical lobar microbleeds (13.3% vs. 60.1%, P < 0.001) than patients with hypertensive arteriolosclerosis. Strictly intracortical/juxtacortical lobar microbleeds were associated with CAA (OR 18.9 [1.9–191.4], P = 0.013), while the presence of subcortical lobar microbleeds was associated with hypertensive arteriolosclerosis (OR 10.9 [1.8–68.1], P = 0.010). Amyloid retention was higher in patients with strictly intracortical/juxtacortical CMBs than those without (SUVR = 1.15 [1.05–1.52] vs. 1.08 [1.02–1.19], P = 0.039). Amyloid retention positively correlated with the number of intracortical lobar microbleeds (P < 0.001) and negatively correlated with the number of subcortical lobar microbleeds (P = 0.018). CAA and cortical amyloid deposition are more strongly associated with strictly intracortical/juxtacortical microbleeds than subcortical lobar microbleeds. Categorization of lobar microbleeds based on anatomical location may help differentiate the underlying microangiopathy and potentially improve the accuracy of current neuroimaging criteria for cerebral small vessel disease.
New reference genomes to distinguish the sympatric malaria parasites, Plasmodium ovale curtisi and Plasmodium ovale wallikeri
Authors: Higgins Matthew , Manko Emilia , Ward Daniel , Phelan Jody E. , Nolder Debbie , Sutherland Colin J. , Clark Taane G. , Campino Susana
Published: February 2024

Despite Plasmodium ovale curtisi (Poc) and wallikeri (Pow) being important human-infecting malaria parasites that are widespread across Africa and Asia, little is known about their genome diversity. Morphologically identical, Poc and Pow are indistinguishable and commonly misidentified. Recent rises in the incidence of Poc/Pow infections have renewed efforts to address fundamental knowledge gaps in their biology, and to develop diagnostic tools to understand their epidemiological dynamics and malaria burden. A major roadblock has been the incompleteness of available reference assemblies (PocGH01, PowCR01; ~ 33.5 Mbp). Here, we applied multiple sequencing platforms and advanced bioinformatics tools to generate new reference genomes, Poc221 (South Sudan; 36.0 Mbp) and Pow222 (Nigeria; 34.3 Mbp), with improved nuclear genome contiguity (> 4.2 Mbp), annotation and completeness (> 99% Plasmodium spp., single copy orthologs). Subsequent sequencing of 6 Poc and 15 Pow isolates from Africa revealed a total of 22,517 and 43,855 high-quality core genome SNPs, respectively. Genome-wide levels of nucleotide diversity were determined to be 2.98 × 10–4 (Poc) and 3.43 × 10–4 (Pow), comparable to estimates for other Plasmodium species. Overall, the new reference genomes provide a robust foundation for dissecting the biology of Poc/Pow, their population structure and evolution, and will contribute to uncovering the recombination barrier separating these species.
Optimizing jet pump efficiency via drag reducing polymers and enhanced efficiency definitions
Authors: AlSarkhi Abdelsalam , Kassar Abdulelah , Sahu Qasim , Gajbhiye Rahul
Published: February 2024

Liquid jet pumps are widely used in various industrial applications for fluid mixing, circulation, and transport. The efficiency and performance of liquid jet pumps play a crucial role in determining their overall effectiveness and economic viability. The performance of liquid jet pumps is primarily affected by parameters such as motive fluid pressure, nozzle design, and entrainment ratio. Liquid jet pumps exhibit a notable drawback in terms of comparatively lower efficiency when compared to alternative pump types. The reduced overall efficiency of liquid jet pumps stems primarily from energy dissipation incurred during the entrainment process. To address this obstacle, a water-water loop system was implemented in conjunction with a liquid jet pump, followed by the introduction of drag-reducing polymers (DRPs) into the suction flow of the liquid jet pump using a specific configuration. This configuration led to a significant reduction in drag within the liquid jet pump, raising its efficiency in some cases from 13.8% to 26.7% with a drag reduction of 46%, subsequently improving its overall performance. The resulting enhancement was evaluated using various efficiency models documented in the existing literature to comprehensively assess the overall performance of the liquid jet pump. A new interpretation of jet pump efficiency has been shared, along with a comparison of the various efficiencies.
A possibility to infer frustrations of supported catalytic clusters from macro-scale observations
Authors: Korobov Alexander
Published: February 2024

Recent experimental and theoretical studies suggest that dynamic active centres of supported heterogeneous catalysts may, under certain conditions, be frustrated. Such out-of-equilibrium materials are expected to possess unique catalytic properties and also higher level of functionality. The latter is associated with the navigation through the free energy landscapes with energetically close local minima. The lack of common approaches to the study of out-of-equilibrium materials motivates the search for specific ones. This paper suggests a way to infer some valuable information from the interplay between the intensity of reagent supply and regularities of product formation.
PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
Authors: Andronikou Christina , Burdova Kamila , Dibitetto Diego , Lieftink Cor , Malzer Elke , Kuiken Hendrik J , Gogola Ewa , Ray Chaudhuri Arnab , Beijersbergen Roderick L , Hanzlikova Hana , Jonkers Jos , Rottenberg Sven
Published: February 2024

Targeting poly(ADP-ribose) glycohydrolase (PARG) is currently explored as a therapeutic approach to treat various cancer types, but we have a poor understanding of the specific genetic vulnerabilities that would make cancer cells susceptible to such a tailored therapy. Moreover, the identification of such vulnerabilities is of interest for targeting BRCA2;p53-deficient tumors that have acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) through loss of PARG expression. Here, by performing whole-genome CRISPR/Cas9 drop-out screens, we identify various genes involved in DNA repair to be essential for the survival of PARG;BRCA2;p53-deficient cells. In particular, our findings reveal EXO1 and FEN1 as major synthetic lethal interactors of PARG loss. We provide evidence for compromised replication fork progression, DNA single-strand break repair, and Okazaki fragment processing in PARG;BRCA2;p53-deficient cells, alterations that exacerbate the effects of EXO1/FEN1 inhibition and become lethal in this context. Since this sensitivity is dependent on BRCA2 defects, we propose to target EXO1/FEN1 in PARPi-resistant tumors that have lost PARG activity. Moreover, EXO1/FEN1 targeting may be a useful strategy for enhancing the effect of PARG inhibitors in homologous recombination-deficient tumors.
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors
Authors: Santofimia-Castaño Patricia , Fraunhoffer Nicolas , Liu Xi , Bessone Ivan Fernandez , di Magliano Marina Pasca , Audebert Stephane , Camoin Luc , Estaras Matias , Brenière Manon , Modesti Mauro , Lomberk Gwen , Urrutia Raul , Soubeyran Philippe , Neira Jose Luis , Iovanna Juan
Published: February 2024

We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven LLPS was crucial for the creation of NUPR1-dependent stress granules (SGs) in pancreatic cancer cells since genetic or pharmacological inhibition by ZZW-115 of NUPR1 activity impeded SGs formation. The KrasG12D mutation induced oncogenic stress, NUPR1 overexpression, and promoted SGs development. Notably, enforced NUPR1 expression induced SGs formation independently of mutated KrasG12D. Mechanistically, KrasG12D expression strengthened sensitivity to NUPR1 inactivation, inducing cell death, activating caspase 3 and releasing LDH. Remarkably, ZZW-115-mediated SG-formation inhibition hampered the development of pancreatic intraepithelial neoplasia (PanINs) in Pdx1-cre;LSL-KrasG12D (KC) mice. ZZW-115-treatment of KC mice triggered caspase 3 activation, DNA fragmentation, and formation of the apoptotic bodies, leading to cell death, specifically in KrasG12D-expressing cells. We further demonstrated that, in developed PanINs, short-term ZZW-115 treatment prevented NUPR1-associated SGs presence. Lastly, a four-week ZZW-115 treatment significantly reduced the number and size of PanINs in KC mice. This study proposes that targeting NUPR1-dependent SGs formation could be a therapeutic approach to induce cell death in KrasG12D-dependent tumors.
Preparation and growth mechanism of centimeter-scale (AgxCu1−x)2ZnSnS4 single crystals via a molten salt method
Authors: Liao Jun , Ye Sihao , Zhu Xupeng , Fu Wenfeng , Xue Shuwen , Qi Jing , Zhang Jun
Published: February 2024

Centimeter-scale high-quality ACZTS single crystals were synthesized by a molten salt method for the first time, and its growth mechanism could be attributed to a type of epitaxial growth process.
A tetrahedron-shaped polyoxoantimotungstate encapsulating a hexanuclear octahedral lanthanide-oxo cluster for an amperometric bromate sensor
Authors: Yu Lan , Ye Jing , Li Da-Huan , Sun Yan-Qiong , Li Xin-Xiong , Zheng Shou-Tian
Published: February 2024

An inorganic antimotungstate 1 is constructed from tetrahedron-shaped two-shell {Nd6(OH)6(H2O)6(B-α-SbW9O33)4} polyanions. Compound 1 exhibits electrochemical activity for the reduction of BrO3− with good selectivity, high sensitivity and low detection limit.
Diversity of transformation of heteroallenes on acenaphthene-1,2-diimine aluminum oxide
Authors: Koptseva Tatyana S. , Skatova Alexandra A. , Moskalev Mikhail V. , Rumyantcev Roman V. , Fedushkin Igor L.
Published: February 2024

This work demonstrates various ways of binding and transformation heteroallenes by acenaphthenediimine aluminum oxide.
3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways
Authors: Tan Yi , Zhou Chunxiu , Miao Lingchao , Zhang Xutao , Khan Haroon , Xu Baojun , Cheang Wai San
Published: February 2024

3,4′,5-Trimethoxy-trans-stilbene (3,4′,5-TMS) alleviates hepatic insulin resistance and oxidative stress through the activation of IRS/PI3K/Akt and Nrf2/NQO1/HO-1 pathways in vitro and in vivo.
Postprandial lipid and vascular responses following consumption of a commercially-relevant interesterified palmitic acid-rich spread in comparison to functionally-equivalent non-interesterified spread and spreadable butter: a randomised controlled trial in healthy adults
Authors: Hall Wendy L. , Alkoblan Aseel , Gibson Philippa S. , D'Annibale Maria , Coekaerts Astrid , Bauer Mathilde , Bruce Johanna H. , Lecomte Beryle , Penhoat Armelle , Laugerette Fabienne , Michalski Marie-Caroline , Salt Louise J. , Wilde Peter J. , Berry Sarah E.
Published: February 2024

Background: Interesterification is an industrial processing technique used to create hard fats where this is essential for functionality and consumer acceptability, e.g. margarines and lower fat spreads.
First application of antimony(iii) corrole for electrocatalytic hydrogen evolution
Authors: Yan Qiao-Wei , Wu Ling-Wei , Liu Zhen-Wu , Chen Feng , Ling Chen , Liu Hai-Yang , Xiao Xin-Yan , Si Li-Ping
Published: February 2024

The application of antimony corrole in HER was explored for the first time. 2-NBPC-Sb exhibited a remarkable TOF of 17.65 s−1, and its Faraday efficiency could reach 87%. The HER with antimony corrole may occur via the ECEC pathway.
Confining calcium oxalate crystal growth in a carbonated apatite-coated microfluidic channel to better understand the role of Randall's plaque in kidney stone formation
Authors: Bourg Samantha , Rakotozandriny Karol , Lucas Ivan T. , Letavernier Emmanuel , Bonhomme Christian , Babonneau Florence , Abou-Hassan Ali
Published: February 2024

The successful formation of a carbonated apatite coating inside a micrometer channel is described, which was used to investigate its role on the formation of calcium oxalate crystals in the context of kidney stones.
Impacts of the reactants on the synthesis of ZnO particles in glycerol-based solvents
Authors: Tabuti Thiago Galeote , Brazuna Lorena Portela , da Silva Joyce Gabrielle , Bacani Rebeca , Candido Rafael Garcia , Furtini Josy Anteveli Osajima , Hurtado Carolina Ramos , Tada Dayane Batista , Triboni Eduardo Rezende
Published: February 2024

Glycerol/additive solvents allow unusual mechanistic routes to form ZnO. Balance between stoichiometry and temperature provides distinct zinc hydroxide forms and zinc oxide particles.
Tridentate chelating ligand based fluorescent Zn(ii) coordination compounds for highly selective detection of picric acid
Authors: Saren Dama , Zangrando Ennio , Puschmann Horst , Manna Subal Chandra
Published: February 2024

Two Zn(ii) complexes with 1-((2-pyridylmethyl)iminomethyl)-2-naphthol ligand show sensitive response to nitroaromatic explosives through luminescence quenching effects. The phenomenon was studied through time-dependent fluorescence technique.
Influence of Gd and Ni doping on the structural, morphological, and magnetic properties of M-type calcium hexaferrite
Authors: Chaurasiya Sanjeev , Kumar Sujeet , Lone Gulzar Ahmad , Kumar Ashish , Sankhala Kirti , Nazir Nazima , Rashid Aaqib , Bhat Showket Ahmad , Ikram Mohd
Published: February 2024

In this study, our aim was to synthesize Gd–Ni doped M-type calcium hexaferrites using a solid-state reaction method.
Mapping the phase-separated state in a 2D magnet
Authors: Mattiat Hinrich , Schneider Lukas , Reiser Patrick , Poggio Martino , Sahafi Pardis , Jordan Andrew , Budakian Raffi , Averyanov Dmitry V. , Sokolov Ivan S. , Taldenkov Alexander N. , Parfenov Oleg E. , Kondratev Oleg A. , Tokmachev Andrey M. , Storchak Vyacheslav G.
Published: February 2024

The spatial distribution of magnetic states in the paradigmatic 4f 2D magnet EuGe2 is probed by a high-sensitivity MFM technique. A phase-separated FM/AFM state is discovered; the length-scale of the magnetic domains amounts to hundreds of nm.
Catalyst-free decarboxylative cross-coupling of N-hydroxyphthalimide esters with tert-butyl 2-(trifluoromethyl)acrylate and its application
Authors: Li Rui , Yin Susu , Xie Lang , Li Xuefei , Jia Jia , Zhao Liang , He Chun-Yang
Published: February 2024

A practical method for the synthesis of CF3-containing amino acids through visible light promoted decarboxylative cross-coupling of a redox-active ester with tert-butyl 2-(trifluoromethyl)acrylate has been developed.
Synthesis, computational chemical study, antiproliferative activity screening, and molecular docking of some thiophene-based oxadiazole, triazole, and thiazolidinone derivatives
Authors: Elgubbi Amna S. , El-Helw Eman A. E. , Alzahrani Abdullah Y. A. , Ramadan Sayed K.
Published: February 2024

Some thiophene-based heterocycles were constructed, examined for their antiproliferative activity, and supported by in silico studies.
Cluster dynamics of heterometallic trinuclear clusters during ligand substitution, redox chemistry, and group transfer processes
Authors: Juda Cristin E. , Handford Rex C. , Bartholomew Amymarie K. , Powers Tamara M. , Gu Nina X. , Meyer Elisabeth , Roth Nikolaj , Chen Yu-sheng , Zheng Shao-Liang , Betley Theodore A.
Published: February 2024

Metal atom lability from a well-defined bimetallic cluster was canvassed as a function of ligand substitution, redox chemistry, and group transfer processes.
Halide-free synthesis of metastable graphitic BC3
Authors: McGlamery Devin , McDaniel Charles , Ladd Dylan M. , Ha Yang , Mosquera Martín A. , Mock Michael T. , Stadie Nicholas P.
Published: February 2024

A halide-free route to the synthesis of graphitic BC3 was discovered via decomposition temperature matching: benzene (C6H6) as the carbon precursor and the borohydride anion (BH4−) as the boron precursor.
Engineering a well-connected ion-conduction network and interface chemistry for high-performance PVDF-based polymer-in-salt electrolytes
Authors: Li Xiaodan , Wang Yucheng , Zhou Qingfeng , Kuai Hongxiang , Ji Chuang , Xiong Xunhui
Published: February 2024

We incorporate HFA into PVDF-based polymer-in-salt solid electrolyte to form n-AGGs with continuous Li-ion transport path and a LiF-rich SEI, enhancing both ionic conductivity and stability. NCM622‖Li cells stably operate over 600 cycles at 0.2C.
Industrial vat orange dyes for organic field effect transistors
Authors: Kahraman Bilge , Yumusak Cigdem , Mayr Felix , Wielend Dominik , Kotwica Kamil , Irimia Cristian Vlad , Leeb Elisabeth , Cobet Munise , Sariciftci Niyazi Serdar , Irimia-Vladu Mihai
Published: February 2024

A group of industrial vat orange dyes i.e. vat orange 1, vat orange 3 and vat orange 9 are investigated for their suitability as semiconductors in organic field effect transistors.
Evaluating the substitution effects of bis(β-iminoenolate)copper(ii) complexes on their photophysical, DNA binding/photocleavage, and cytotoxic activities
Authors: Prasanth Panneerselvam Arun , Nantheeswaran Periyappan , Prabakaran Kaliyan , Senthilnathan Rajendran , Lukmanul Hakkim Faruck , Jothi Arunachalam , Perumal Muthu Seenivasa , Anbazhagan Veerappan , Mariappan Mariappan
Published: February 2024

Substituent in a ligand modulate the bioactivity of the bis(β-iminoenolate)copper(ii) complexes.
Thiourea-Cu(OTf)2/NIS-synergistically promoted stereoselective glycoside formation with 2-azidoselenoglycosides or thioglycosides as donors
Authors: Li Zuowa , Shen Wenyan , Cao Changyu , Wang Zhaoyan , Zhang Yaosheng , Xue Weihua
Published: February 2024

NIS with a catalytic amount of thiourea and Cu(OTf) composes a powerful activator system for 2-azidoselenoglycoside and thioglycoside donors, allowing stereoselective glycosylation of alcoholic receptors to furnish the expected glycosides.
Correction: Phosphine oxide based semiconducting small molecule as an additive and an electron transport layer enables efficient and stable perovskite light-emitting devices
Authors: Mukherjee Susmita , Panigrahi Ashutosh , Lin Yen-Hung , Perumal Ajay
Published: February 2024

Correction for ‘Phosphine oxide based semiconducting small molecule as an additive and an electron transport layer enables efficient and stable perovskite light-emitting devices’ by Susmita Mukherjee et al., J. Mater. Chem. C, 2024, https://doi.org/10.1039/d3tc04461k.
The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys
Authors: Dissanayake Lashodya V. , Kravtsova Olha , Lowe Melissa , McCrorey Marice K. , Van Beusecum Justin P. , Palygin Oleg , Staruschenko Alexander
Published: February 2024

The development of the kidney involves essential cellular processes, such as cell proliferation and differentiation, which are led by interactions between multiple signaling pathways. Xanthine dehydrogenase (XDH) catalyzes the reaction producing uric acid in the purine catabolism, which plays a multifaceted role in cellular metabolism. Our previous study revealed that the genetic ablation of the Xdh gene in rats leads to smaller kidneys, kidney damage, decline of renal functions, and failure to thrive. Rats, unlike humans, continue their kidney development postnatally. Therefore, we explored whether XDH plays a critical role in kidney development using SSXdh-/- rats during postnatal development phase. XDH expression was significantly increased from postnatal day 5 to 15 in wild-type but not homozygote rat kidneys. The transcriptomic profile of renal tissue revealed several dysregulated pathways due to the lack of Xdh expression with the remodeling in inflammasome, purinergic signaling, and redox homeostasis. Further analysis suggested that lack of Xdh affects kidney development, likely via dysregulation of epidermal growth factor and its downstream STAT3 signaling. The present study showed that Xdh is essential for kidney maturation. Our data, alongside the previous research, suggests that loss of Xdh function leads to developmental issues, rendering them vulnerable to kidney diseases in adulthood.
Introducing LensCharm
Authors: Rüstig Julian , Guardiani Matteo , Roth Jakob , Frank Philipp , Enßlin Torsten
Published: February 2024

Strong gravitational lensing, a phenomenon rooted in the principles of general relativity, grants us a unique window into the distant cosmos by offering a direct probe into dark matter and providing independent constraints on the Hubble constant. These research objectives call for the utmost precision in the estimation of the lens mass and the source brightness distributions. Recent strides in telescope technology promise to provide an abundance of yet undiscovered strong-lensing systems, presenting observations of unprecedented quality. Realizing the full potential of these advancements hinges on achieving the highest fidelity in both source and lens reconstruction. In this study, we introduce LensCharm, a novel Bayesian approach for strong-lensing signal reconstruction. Unlike more prevalent methods, LensCharm enables the nonparametric reconstruction of both the source and lens concurrently, along with their associated uncertainties. We showcase the distinctive strengths of our approach through comprehensive analyses of both real-world and simulated astronomical data, underscoring its superiority in achieving precise reconstructions. We have made LensCharm publicly accessible, envisioning its empowerment of the next generation of astronomical observation reconstructions and cosmological constraints derived from strong gravitational lensing.
Consecutive pattern-avoidance in Catalan words according to the last symbol
Authors: Baril Jean-Luc , Colmenares Daniela , Ramírez José L. , Silva Emmanuel D. , Simbaqueba Lina M. , Toquica Diana A.
Published: February 2024

We study the distribution of the last symbol statistics on the sets of Catalan words avoiding a consecutive pattern of length at most three. For each pattern p, we provide a bivariate generating function, where the coefficient cp(n,k) of xnyk in its series expansion is the number of length n Catalan words avoiding p and ending with the symbol k. We deduce recurrence relations or closed forms for cp(n, k) and we provide asymptotic approximations for the expectation of the last symbol on all Catalan words avoiding p. Finally, we characterize the sequence cp(n, k) using Riordan arrays.
Development and assessment of test-retest reliability of a new field test to evaluate lower-limb muscle fatigability in young adults
Authors: Souron Robin , Colard Julian , Ruiz-Cárdenas Juan D. , Beltran Anicée , Duché Pascale , Gruet Mathieu
Published: February 2024

We aimed to develop a new field test to evaluate lower-limb muscle fatigability in young adults. In Experiment–A, we developed and determined the ability of an intermittent isometric wall-squat test to induce progressive level of muscle fatigability, as detected by the kinetics of changes in squat-jump height (SJH) and sit-to-stand time (STST) computed using two smartphone applications for feasibility purposes. In Experiment–B, participants performed the same test on two different days for reliability assessment. Kinetics of changes in our fatigability indicators were registered at isotime, exhaustion, and Post2min. The minimal detectable change (MDC95) and the absolute (CVTE) and relative (ICC3-1) reliability coefficients were assessed. In Experiment–A, we reported a progressive decrease in performance for SJH and STST throughout the task, reaching at exhaustion mean changes of −22±11% and +31±13%. Individual data-analysis showed decrease in performance for SJH and STST greater than the MDC95 in 85% and 95% of participants. In Experiment–B, changes in our fatigability indicators demonstrated excellent inter-session reliability at isotime, exhaustion and Post2min for SJH (ICC3-1 > 0.97; CVTE < 7.5%) and STST (ICC3-1 > 0.92; CVTE < 3.3%). This test is feasible and reliable, making it very promising for evaluating muscle fatigability in applied (e.g. clinical) and laboratory settings.
Therapie und Training bei Tendinopathien
Authors: Köcker Sebastian , Kubosch Eva Johanna , Morath Oliver , Buhl Julian
Published: February 2024

Tendinopathien sind ein häufiges Krankheitsbild in der
physiotherapeutischen Praxis, und es stellt sich die Frage, wie wirksam trotz
der Schmerzsymptomatik Therapie und Training sind. Dies vor allem auch vor dem
Hintergrund, dass der genaue Mechanismus für das Entstehen einer
Tendinopathie nicht vollständig geklärt ist. Dieser
Refresher-Artikel erklärt die aktuellen Hypothesen zur Entstehung einer
Tendinopathie und zeigt Therapieansätze sowie Trainingsprinzipien
für das im Wesentlichen überlastungsinduzierte
Beschwerdebild.
Abdominal Wall Hernias Following High-intensity Focused Ultrasound Therapy: Three Case Reports
Authors: Han Woo Yeon , Kim Yeongsong , Kim Pyeong Hwa , Kim Eun Key
Published: February 2024

Although many studies reported the safety and efficacy of high-intensity focused ultrasound (HIFU) therapy, there are still worries about internal organ injury. However, reports of abdominal wall hernias after HIFU therapy are rare.

We present three cases of abdominal wall hernias without skin injury after HIFU therapy in uterine adenomyosis or fibroids. The diagnosis was often delayed because of vague symptoms, inadequate clinical suspicion, and delayed proper image studies.

Abdominal wall hernia should be recognized as a possible complication after HIFU and be suspected when the patient presents with unordinary abdominal swelling and/or pain that lasts for more than a few months after the procedure.
Racial Differences in Bleeding Risk: An Ecological Epidemiological Study Comparing Korea and United Kingdom Subjects
Authors: Kang Dong-Seon , Yang Pil-Sung , Kim Daehoon , Jang Eunsun , Yu Hee Tae , Kim Tae-Hoon , Sung Jung Hoon , Pak Hui-Nam , Lee Moon-Hyoung , Lip Gregory Y.H. , Joung Boyoung
Published: February 2024

Background This study aimed to evaluate racial differences in bleeding incidence by conducting an ecological epidemiological study using data from Korea and the United Kingdom.

Methods We included healthy participants from the Korean National Health Insurance Service-Health Screening and the UK Biobank who underwent health examinations between 2006 and 2010 and had no comorbidities or history of medication use. Finally, 112,750 East Asians (50.7% men, mean age 52.6 years) and 210,995 Caucasians (44.7% men, mean age 55.0 years) were analyzed. The primary outcome was composed of intracranial hemorrhage (ICH) and bleeding from the gastrointestinal, respiratory, and genitourinary systems.

Results During the follow-up, primary outcome events occurred in 2,110 East Asians and in 6,515 Caucasians. East Asians had a 38% lower 5-year incidence rate compared with Caucasians (3.88 vs. 6.29 per 1,000 person-years; incidence rate ratio [IRR]: 0.62, 95% confidence interval [CI]: 0.59–0.65). East Asians showed a lower incidence of major bleeding (IRR: 0.86, 95% CI: 0.81–0.91), bleeding from the gastrointestinal (IRR: 0.53, 95% CI: 0.49–0.56), and genitourinary systems (IRR: 0.49, 95% CI: 0.44–0.53) compared with Caucasians. The incidence rates of ICH (IRR: 3.20, 95% CI: 2.67–3.84) and bleeding from the respiratory system (IRR: 1.28, 95% CI: 1.11–1.47) were higher in East Asians. Notably, East Asians consuming alcohol ≥3 times/week showed a higher incidence of the primary outcome than Caucasians (IRR: 1.12, 95% CI: 1.01–1.25).

Conclusion This ecological study revealed significant racial differences in bleeding incidence, influenced by anatomical sites and lifestyle habits, underscoring the need for tailored approaches in bleeding management based on race.
See who I know! Addressing the liabilities of outsidership through status signaling
Authors: Carney Michael , Dieleman Marleen
Published: February 2024

Status is an important intangible asset, yet when firms enter new countries, they lack standing in new social hierarchies as outsiders. Conventional wisdom suggests embeddedness in host-country networks can alleviate newcomers’ liability of outsidership. We complement this with insights from status signaling theory: Newcomers in host countries can address their liability of outsidership through the visual display of social affiliations. We utilize a novel visual qualitative research approach that analyzes annual report photographs of an emerging-market family business, depicting the firm’s leaders with high-status alters. Complementing the international business literature, which emphasizes strong ties to host-country business partners, we identify three signaling mechanisms that are more circuitous: bypass (host-country affiliations beyond the firm’s industry), allusion (global affiliations beyond the host country and industry, often celebrities), and aspiration (global industry affiliations). We also suggest that such diffuse status signaling mechanisms may be especially salient in emerging-market family firms investing in developed markets, which are accorded low status in many developed markets. These firms feature firm/owner identity overlaps, long leader tenures, and a tendency to build reputation through prosocial behavior, facilitating the activation of status signaling tactics through ephemeral affiliations with high-status actors situated in world society.