bluuebunny/crossref_metadata_2025 huggingface dataset:
Cognitive Absorption during Interaction with Short-Form Travel Videos and Its Influence on Users' Intentions to Travel
Authors: Zhou Han
Published: October 2024

Short-form travel videos are gaining more attention from marketers and advertisers for their destination marketing effectiveness and value. However, few studies have explored how short-form travel videos influence people's destination visit intention in detail. On the other hand, in existing research on cognitive absorption, the exploration of the relationships between the internal sub-constructs of cognitive absorption remains in its early stages. This study aims to apply cognitive absorption theory to the context of short-form videos and destination research, attempting to explain the impact of short-form videos on users' intentions to visit destinations from the perspective of the deep engagement experienced by users during audiovisual interaction. Focusing on Chinese short-form video users, this study, through empirical research, reveals the path through which users' cognitive absorption experiences while watching short videos influence their travel-related behavioral intentions. Additionally, the study uncovers the internal hierarchical structure of cognitive absorption. These findings provide theoretical insights and practical implications for understanding user engagement and its impact on travel behavior.
FORMULATION DEVELOPMENT AND MEASUREMENT OF ANTIOXIDANT ACTIVITY OF ELEUTHERINE AMERICANA MERR TEA CUBE
Authors: MENTARI IKA A. , HAIRUNISA INDAH , KUSTIAWAN PAULA M. , BAKAR MOHD F. A. , BAKAR FAZLEEN I. A. , MARDIANA EVA
Published: October 2024

Objective: The current study was conducted to develop Eleutherine americana Merr (Bawang dayak) as Teacube and to investigate its antioxidant activity.
Methods: Eleutherine americana Merr was extracted using the infusion method. To make the tea cube, this extract was combined with molasses and granulated sugar. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical inhibiton method was used to assess antioxidant activity. Finally, a hedonic test was used to determine the formula's acceptability.
Results: The antioxidant activity in the Eleutherine americana Merr teacube formula was found to have IC50 values of 60.35, 51.87, 79.85, and 53.36 ppm for formulas I,II,II,IV, respectively. The result of hendonic test showed that formula II had the best acceptence for color (3.53), flavor (3.58), odor (3.67), texture (4.00) and acceptability (4.00)
Conclusion: Eleutherine americana Merr teacube formulation presented has antioxidant activity and has great for antioxidant agent and also can be accepted by the panelists
ENHANCING CELL METABOLIC ACTIVITY USING MICROPARTICLES CONTAINING BEETROOT (BETA VULGARIS, LINN) EXTRACT
Authors: SUKMAWATI ANITA , NURWAINI SETYO , AZIMAH JIHAN NAUFA , SAPUTRI ANISA JEVI ROMANDANI
Published: October 2024

Objective: The aim of this study was to assess the efficacy of delivering beetroot (Beta vulgaris, Linn) juice extract, which contains antioxidants, using Ethyl Cellulose (EC) and chitosan microparticles on cell metabolic activity.Methods: The beetroot extract microparticles were produced by using EC and chitosan as a matrix. Different concentrations of the matrix were used in the primary solution during microparticles preparation. The physical characterisation was conducted, including Scanning Electron Microscope (SEM) and zeta potential. The entrapment of the active substance was measured using the Encapsulation Efficiency (EE) and Drug Loading (DL). The Vero cell was treated with EC and chitosan microparticles for 28 d and the cell metabolic activity was measured using resazurin assay. Results: The findings indicated that the entrapment of beetroot extract in microparticles was affected by the concentration of EC and chitosan. The delivery of an antioxidant substance from beetroot extract resulted in an increase in cell metabolic activity indicated by cells proliferation from day 7 to day 21, in comparison to the control group. Conclusion: The antioxidant as an active compound from beetroot juice extract were successfully delivered to the cell via the EC and chitosan microparticle indicated by impact on metabolic activity. The metabolic activity of the cell is influenced by the quantity of active substance contained within the microparticle and the type of polymer used as the microparticle matrix. The EC microparticle demonstrated a greater capacity to stimulate cell metabolic activity in comparison to chitosan microparticles.
LITERATURE STUDY: INTERACTION BETWEEN NATURAL ANTIOXIDANT COMPOUNDS IN TROPICAL FRUITS
Authors: RAHMASARI ARDITA T. , KURNIA PRAMUDYA
Published: October 2024

Objective: This study aims to analyze selected articles on interactions in binary combinations of vitamin c, phenolic compounds, flavonoids, and carotenoids.
Methods: The method used in this research is a literature study approach through the Google Scholar database with the last 10 years (2013 – 2023) of research articles. The selected journals are internationally reputable with Scopus index Q1-Q4 and the results of experimental research.
Results: The analysis of the six selected articles showed synergistic interactions in the combination of vitamin c with phenolics, vitamin c with carotenoids, phenolics with flavonoids, phenolics with carotenoids, and flavonoids with carotenoids. However, antagonistic interactions can also occur in some of these combinations and the combination of vitamin c with flavonoids. This is influenced by several factors, such as the type of antioxidant compound derivative, variation in concentration ratio, differences in oxidation potential and antioxidant bond dissociation energy.
Conclusion: Overall, binary combinations of antioxidants result in different interactions. This is influenced by several factors. However, the lack of research articles on the combination of these antioxidant binary compounds means that it is not known exactly how the mechanism of interaction in these combinations can occur.
MODIFICATION AND CHARACTERIZATION OF AMPROTAB WITH HYDROXYPROPYL METHYLCELLULOSE USING CITRIC ACID AS CROSSLINKING AGENT
Authors: SUPRAPTO SUPRAPTO , SULAIMAN TEUKU NANDA SAIFULLAH , ROHMAN ABDUL , NUGROHO AKHMAD KHARIS
Published: October 2024

Objective: This study aimed to characterize Amprotab that has been modified chemically, physically, and mechanically using HPMC and citric acid.
Methods: The study is divided into two parts: three control formulas and three treatment formulas. Control Formula 1 (without HPMC and citric acid), Control 2 (HPMC 1.5 g without citric acids), Control 3 (citric acid 1.5 g without HPMC), Formula 1 (HPMC 4.5 g and citric acid 4.5 g). By analyzing Fourier Transform Infrared (FTIR), scanning electron microscopy (SEM), swelling, tensile strength, stability (freeze-thaw cycles), X-ray Diffraction (XRD), and Thermogravimetric Analysis (TGA), copolymers modified by Amprotab were characterized.
Results: An FTIR analysis revealed that crosslinking of Amprotab was formed in formulas 1, 2, and 3 with prominent C=O ester bonds at peaks of 1730.22 cm-1, 1733.12 cm-1, and 1736.01 cm-1. The surface morphology of the modified cassava amylum CROSSLINKED COPOLYMER (CCA) was coarser. CCA's expanding power is less than that of natural Amprotab, whereas CCA's tensile strength is greater.
Conclusion: CCA has a high value for syneresis. XRD analysis revealed that CCA has a crystal diffraction pattern of type B, and TGA analysis revealed that CCA is stable at high temperatures.
Discapacidad y género: la interseccionalidad de la mujer indígena
Authors: Casas Olivera Marisol
Published: October 2024

La realidad se encuentra en constante cambio por varios factores de índole política, económica, social, cultural y educativa, e incide en países multiculturales como México, que alber-ga 68 lenguas originarias, más sus variantes, y cuyos hablantes tienen sus propias maneras de pensar, ser y estar en el universo. Sin embargo, el marco legal es insuficiente para atender las demandas de las personas con discapacidad pertenecientes a estos grupos, en especial a las mujeres indígenas en dicha condición que tienen mayor vulnerabilidad y, por lo tanto, experimen-tan más desafíos. Por ello, en este artículo se entrelazan tres categorías intersecadas por nociones de género, cultura y sociedad en la voz de Constanza, quien hace visible su sentir, pen-sar y actuar. A través de su narrativa nos acerca a los sentidos y significados que construye una mujer ayuuk con discapacidad visual, que ha experimentado en su camino la discriminación por su condición física, social y cultural en una sociedad excluyente que solo valida lo uniforme.
Precisión de los perfiles de autor en portales institucionales de producción científica
Authors: Bravo-García Inmaculada , Merlo Vega José Antonio , Montoya-Roncancio Valeria
Published: October 2024

Las universidades difunden su producción científica a través de portales de investigación donde integran las publicaciones de sus investigadores, las cuales proceden de bases de datos bibliográficas como Web of Science. Este estudio examinó la correspondencia entre la información de los investigadores de la Universidad de Salamanca en Web of Science y en el Portal de la Investigación de la USAL. La metodología empleada fue mixta e incluyó técnicas de análisis automatizados y manuales para el tratamiento de datos de Web of Science que permitieron identificar las inconsistencias en los datos de publicaciones y autores. Se desarrolló una metodología en cinco fases que apoyó en la extracción semiautomática de identificadores ResearcherID de Web of Science de los investigadores que carecían de dicho identificador en el Portal USAL, así como en la validación de la corrección de los identificadores existentes. El método utilizado en el análisis y en la tipificación de incidencias son replicables en cualquier entidad de investigación. Las conclusiones determinan la consistencia de la información procedente de Web of Science, abogan por la autonomía de las plataformas institucionales de las fuentes externas y ofrecen soluciones para alcanzar la mejor calidad en los datos de una universidad en las plataformas comerciales de producción científica.
A Study on the Validity of Automatically Generated Questions Using the Q-Craft
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Moonjung , Lee Yongsang
Published: October 2024

Objectives In an environment where the demand for automatic item generation is increasing, it is crucial for automatically generated items to match the quality of manually created items to be effectively utilized in educational settings. This study aims to automatically generate items (AIG items) similar to traditional manually generated items (MIG items) using an automatic item generation program and to evaluate the validity of these automatically generated items by analyzing their similarity to MIG items.
Methods 15 representative items types from the March 2023 National Assessment of Education for 12th grade, administered by the Seoul Metropolitan Office of Education, were selected to form the MIG items. Similarly, 15 AIG items were generated using the Q-Craft automatic item generation program. The AIG items were subjected to blind review by 10 subject-matter experts and were simultaneously administered along with the MIG items to 48 first-year university students.
Results The expert review of the AIG items indicated a high level of naturalness in the flow of the passages and the use of English expressions. However, the attractiveness of the answer choices received relatively lower ratings. The analysis of the responses from the university students revealed a high degree of similarity between the MIG and AIG items, with a parallel test reliability of .662. Furthermore, the comparison using test information functions showed that the ability levels of students providing the maximum test information were identical for both sets of items.
Conclusions The AIG items are not yet fully equivalent to the MIG items. Nonetheless, the fact that the AIG items accurately estimated the ability levels of students, as the MIG items did, is highly significant. This suggests that AIG items can be deemed valid depending on the testing purpose.
A Qualitative Meta-Analysis of PBL Experiences
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Yeong Je , Kim Min Jun , Park So Min , Won Jong Su , Kim Dae Kwon
Published: October 2024

Objectives The purpose of this study is to elicit student and teacher experiences with PBL, as well as to offer a categorized situational model that provides key data for integrating PBL into classroom ecosystems.
Methods A total of 38 papers were selected through a systematic procedure and subjected to qualitative meta-analysis. To extract the classroom experiences of students and teachers in PBL, each paper was individually analyzed, and key elements were drawn out. Then, common elements were synthesized and categorized. Ultimately, a situational model that visualized the PBL class experience was proposed.
Results Students perceived PBL as intriguing and demonstrated proactive and collaborative attitudes. They developed a deep understanding of the course content and acquired abilities essential for a future society. Conversely, they expressed reluctance due to unfamiliarity, and conflicts arose from non-participation. Teachers recognized PBL as a learner-centered instructional approach but faced challenges in implementation due to a lack of experience. There were both positive and negative environmental factors, and teachers overcame difficulties by applying practical knowledge.
Conclusions It is recommended that, to effectively establish PBL within classroom ecosystems, training and the activation of teacher communities are essential, along with comprehensive changes in the educational environment.
Sozinha — análise do conto “The Bride”, de Maeve Brennan
Authors: Siqueira Sabrina , Umbach Rosani Ketzer
Published: October 2024

Este artigo analisa o conto “The Bride”, da escritora irlandesa Maeve Brennan, sob o enfoque da diáspora irlandesa para os EUA e em especial da migração feminina. Como referencial teórico, é utilizada a teoria de identidade fragmentada, de Stuart Hall; memória, de Halbwachs, e alteridade, de Silva; além de uma visada em artigos de McWilliams e Murphy, entre outros, como crítica literária à obra de Brennan.
Teoria, autoria...
Authors: Carvalho Fábio Almeida
Published: October 2024

O ensaio realiza espécie de traveling sobre os processos de construção e de expansão de sentidos das noções de autor/autoria, relacionando essas mesmas questões com as condições do saber e do fazer teórico-crítico no campo dos estudos literários, em particular, e das humanidades, em geral.
Algumas considerações sobre os minimizadores no português brasileiro: contextos (não) afetivos e escalas
Authors: Beviláqua Kayron
Published: October 2024

Este artigo discute algumas propriedades dos minimizadores no Português Brasileiro. Partindo de Ilari (1984), talvez o primeiro e um dos poucos trabalhos sobre polaridade negativa no Português Brasileiro, abordamos a restrição de tais expressões a contextos negativos e apresentamos brevemente o modelo de Chierchia (2013). Também discutimos certos contextos de acarretamento decrescente, inerentes ao licenciamento de minimizadores. Em seguida, investigamos o fenômeno da afetividade, argumentando que, apesar de, a princípio, esse aspecto parecer escapar à abordagem de Chierchia (2013), é possível explicar tais nuances levando em consideração a definição escalar do minimizador. Por fim, indicamos uma possível existência de uma classe de minimizadores de escala não definida lexicalmente, isto é, itens que funcionam como minimizadores, mas que não possuem uma escala definida em sua entrada lexical, como o nem a pau e o nem fodendo.
'Se pá' um condicional epistêmico!
Authors: Oliveira Roberta Pires de , Costa de Carvalho Bernar
Published: October 2024

Este artigo tem como objetivo apresentar uma proposta para a semântica-pragmática da expressão ‘se pá’, característica da fala de comunidades mais jovens no Brasil.  Em textos escritos, como whatsapp ou twitter, aparece grafada de maneiras distintas: ‘cepá', 'sepá', 'cpá' e etc.... Argumentamos que se trata de uma expressão composicional, em que o ‘se’ é a conjunção condicional e o ‘pá’ ocupa o lugar da sentença antecedente. Defendemos inicialmente que não estamos diante de um operador de possibilidade como ‘talvez’, mas de um condicional indicativo, já que não se combina com formas do verbo no subjuntivo. Mostramos, com base em Potts (2007), que o ‘pá’ carrega expressividade, veiculando a posição subjetiva do falante. Para a semântica, partimos da proposta de Kratzer (2012) para os condicionais em que o ‘se’ indica que a restrição da quantificação universal, que é implícita, é dada pelo antecedente. O antecedente está ocupado por ‘pá’, que veicula  que as restrições são aquilo que é o curso normal dos eventos. A base modal são os mundos acessíveis a partir do mundo de avaliação, que são ordenados segundo a normalidade. O ‘pá’ é a proposição que resume as condições normais. Assim, o falante indica que se tudo for normal, o consequente se segue. Logo, ele não apenas está inclinado na direção do consequente, mas a expressividade da expressão veicula que o falante está emocionalmente inclinado nessa direção.
Sobre a semântica de ‘juntos’ no português brasileiro: tipologia e investigação preliminar
Authors: Araújo Ana Carolina de Sousa , Miguel Basso Renato
Published: October 2024

Neste artigo, realizaremos uma investigação preliminar sobre a expressão 'junto', que ainda não conta com uma descrição no português brasileiro (PB). Para empreender este estudo, nosso primeiro passo será demonstrar, por meio de testes linguísticos, as interpretações que o termo pode ter em sentenças do PB e oferecer uma tipologia semântica. Na segunda etapa deste artigo, apresentaremos duas teorias propostas para o item together, que pode ser entendido como a contraparte do 'junto' na língua inglesa, e investigaremos se essas teorias dão conta dos dados apresentados para a expressão no PB. Por fim, apresentaremos uma primeira descrição teórica para o 'junto' no PB, com base na hipótese de que a função deste item é a de efetuar uma soma de entidades. Na Conclusão, retomaremos o caminho percorrido e as principais conclusões, além de citar brevemente outras questões sobre o 'junto' que merecem nossa investigação.
Língua e cosmogonia em Bakairi: práticas de pesquisa voltadas ao conhecimento das línguas originárias
Authors: Souza Tania Conceição Clemente de , Xagope Valdo Kutaiava
Published: October 2024

O trabalho toma como objeto a língua Bakairi (Caribe), modalidade falada na Terra Indígena Bakairi, localizada no município de Paranatinga, Mato Grosso, Brasil Central. Os dados foram coletados, sobretudo, em duas aldeias – a Aldeia Pakuenra e a Aldeia Paikun, ambas localizadas na Terra Indígena Bakairi. O objetivo principal a ser alcançado visa a organização do léxico na língua Bakairi, descrita e analisada sob uma perspectiva interdisciplinar, colocando em jogo a relação entre língua e cosmogonia, quando se trabalha pelo viés da escola francesa de Análise de Discurso e, paralelamente, trabalha-se a análise formal dos dados nos moldes da Morfologia Derivacional. Como objetivos secundários, procuramos focalizar dois mecanismos principais: (i) a discussão da formação de palavras motivadas pela cosmogonia do grupo através da presença de formativos (morfemas) fechados e não produtivos, ficando estes restritos à criação de palavras num tempo mítico e (ii) a análise de outros morfemas da língua, dando lugar a palavras abertas. Dentre o conjunto de palavras fechadas, as que fundam a identidade dos Kurâ e que nos remtem à organização social do povo em seu todo e aos valores de ordem moral e social, escolhemos duas para ser o foco de nossa discussão: udodo e pekobaym. O enfoque aqui apresentado contribui ao conhecimento e descrição do sistema da língua tanto para falantes nativos, quanto a pesquisadores que se voltem para a dimensão étnica inscrita na materialidade discursiva da língua.
Conceptualización de “el yo” en las redes sociales. Afectos y relato entre lo verbal y no verbal
Authors: Picado Sánchez Manuel J. , Sibón Macarro Teresa-G. , Koffermann Marcia , Marques Gonçalves Bruna Caroline
Published: October 2024

En el presente ensayo se procura reflexionar sobre la contemplación de “el yo” por el sujeto mismo cuando exporta a las redes sociales su imagen personal; para ello crea un relato entre palabras e imágenes con intención de ser aceptado. Se interpela mediante una reflexión crítica y se pone el enfoque de un prosumidor hipotético (Toffler, 1980) que aporta su versión de “el yo” con la que se identifica o hace por encajar entre realidad y deseo. Es un planteamiento interdisciplinar y multitextual de ese comunicar su rostro, su cuerpo y su vida por medio de unos parámetros positivos (Erikson, 1974; Festinger, 1957, Kaplún, 1998). Se observa la recurrencia para mostrarse uno mismo, sea con una imagen real y genuina o sea manipulada hacia la trazada y alzada de una versión idealizada (Barker, 2020; Koffermann, 2024). Se propone una revisión para el diseño de algunos talleres cuyos objetivos versan sobre el fomento de la autoestima, el afianzamiento de estrategias para la aceptación y la apertura a la diversidad. Además, se elige un formato ensayístico para tamizar y percibir ese impacto de la versión o las versiones de la autoimagen de adolescentes en las redes sociales, lo que será presentado como un reto de la formación del profesorado en educación mediática (https://www.redalfamed.org/vii-congreso-2024-costarica). A partir de la discusión constructiva, se pretende ofrecer pautas para la intervención, tanto desde el ámbito de la educación  como desde el área de salud; las estrategias se sustentan en el análisis del relato multimodal que emerge de las definiciones con las que cada sujeto proyecta su “yo”.
Docentes influencers: Innovación digital y desafíos éticos en la educación del futuro
Authors: González Carrión Erika Lucía , Rojas Estrada Elizabeth Guadalupe
Published: October 2024

Este texto analiza el fenómeno de los docentes influencers, destacando su definición, los retos que enfrentan y las oportunidades que ofrecen tanto en la educación como en los medios. Las personas docentes influencers son profesionales que, además de su labor en el aula, utilizan plataformas digitales y redes sociales para compartir contenido educativo, interactuar con sus comunidades y generar impacto más allá del entorno escolar tradicional. Entre los desafíos que enfrentan se encuentran la gestión de la exposición pública, la conciliación entre su rol como profesores y creadores de contenido, y la adaptación a las demandas de la era digital.Sin embargo, este fenómeno también ofrece nuevas perspectivas para transformar la educación, favoreciendo la innovación pedagógica y el acceso a recursos educativos. A través de estas plataformas, contribuyen a la democratización del conocimiento y al fortalecimiento de una comunidad educativa más conectada y colaborativa.
Characteristics of Italian firms in the judicial administration: Can financial ratios be red flags of criminal infiltrations?
Authors: Greco Angela Maria , Messina Mariastella
Published: October 2024

In recent years, the importance of studying criminal infiltration in firms, especially in the context of accounting practice, cannot be underestimated. The paper aims to analyse firms under judicial administration (JA) to better understand where firms operate by investigating whether certain financial ratios can serve as red flags indicating criminal infiltration. The study examines a sample of 108 firms operating in the Italian context undergoing JA. Findings show that most of the firms were small, located in the south of Italy, structured as limited liability companies, active but undergoing insolvency procedures, and operating in the construction, wholesale and retail trade, car and motorcycle repair, rental, travel agencies, business support services, and real estate sectors. The analysis shows that firm size, performance, and debt can be used as red flags to indicate criminal infiltration. The results provide useful insights for understanding how accounting practices can help to identify criminal infiltration in firms.
Early Childhood Pre-service Teachers' Perceptions of Teacher-(Vice)Principal Relationship Using Metaphor Analysis: Focusing on the Educational Community Perspective
Authors:   The Korea Associantion For Early Childhood Education Administration, Song Yun-Na , Choi Ara
Published: October 2024

The purpose of this study is to examine prospective early childhood pre-service teachers' perceptions of the teacher-(vice)principal relationship using metaphor analysis, and to provide implications regarding the desirable teacher-(vice)principal relationship that prospective early childhood pre-service teachers should form from an educational community perspective. For this purpose, data were collected from November 30 to December 22, 2023, targeting 135 students majoring in early childhood education and child studies at a 4-year university located in G Metropolitan City. The collected data were analyzed according to an 8-step metaphor analysis procedure and the results were presented. As a result of the study, childhood pre-service teachers' perceptions about the teacher-(vice)principal relationship were characterized into three categories and eight subcategories. The three categories are: ‘Relationship between leader and follower walking the same path’, ‘Relationship of cooperation based on trust and respect’, ‘Relationship of imbalance of power’. The eight subcategories are: ‘relationship of providing and receiving support for the driving force of educational implementation’, ‘relationship of cooperation as a member of the early childhood education community’, ‘relationship of suggesting and following direction’, ‘relationship of giving teaching and receiving learning’, ‘relationship between the strong and the weak’, ‘relationship in which we are emotionally embraced and supported’, ‘relationship in which we trust and respect each other’, ‘relationship in which we are different but must maintain a balance’ This study is expected to provide basic data for education and research to establish an educational community culture in the early childhood education field.
A Critical Analysis of Science And Technology’s Impact on The Re-Evaluation of Iddah From Al-Talil Bi Al Hikmah Perspective
Authors: Lokman Md Azzaat Ahsanie , Muhammad Fadzil Muhammad Faidz , Raffar Izzah Nur Aida Zur , Abd Razak Muhd Imran , Abdul Rahman Mohd Farhan
Published: October 2024

In contemporary Islamic discourse, there is an increasing emphasis on the role of wisdom in determining Islamic law due to its significant connection with the concepts of ?illah and Maqasid Shariah. This discussion in U??l al-Fiqh is known as al-Ta?l?l bi al-?ikmah. Additionally, the rapid advancements in modern science and technology are recommended for integration into contemporary Islamic legal research. Thus, exploring the intersection of wisdom and science is crucial. One of the issues that is often a concern in responding to the relationship between wisdom and science within Islamic law is the rule of iddah. This study aims to investigate the relationship between the rule of iddah and its underlying wisdom, as well as the role of science in realizing this wisdom and its impact on legal rulings. A qualitative approach was employed, using document analysis of both classical and contemporary writings on the rule of iddah. The analysis was conducted inductively to identify the principles of al-Ta?l?l bi al-?ikmah, which form the primary framework for examining the iddah issue. This study finds that if the use of wisdom and science in determining Islamic rules aims at realizing the objectives of the Shariah, performed by its guidelines, then it conforms with the requirements of Shariah and achieves Maqasid Shariah.
Safeguarding of the intangible cultural heritage and museums - between the administrative framework and museum practice in Serbia
Authors: Filipovic Danijela
Published: October 2024

The adoption of the Convention of Safeguarding of the Intangible Cultural
Heritage, as well as the establishment of the concept of the safeguarding of
intangible cultural heritage, contributed to the reconsideration of tasks of
museums and to the inclusion of museums in the system of safeguarding of
living heritage. The paper analyzes the framework that was established at
the international and national levels, implementation of administrative
measures and outlines new responsibilities assigned to museums. The aim of
the paper is to review the ways and implications of introducing the concept
of safeguarding of intangible cultural heritage into museum practice in
Serbia, focusing on the challenges that are faced by the work to safeguard
cultural heritage in collaboration with communities in the context of
identifying, researching, recording, and presenting ICH.
Challenges of the intangible cultural heritage safeguarding system in multiethnic states: The example of the Serbian community in Herzegovina
Authors: Drazeta Bogdan , Cukovic Jelena , Milenkovic Marko
Published: October 2024

The challenges and problems in the safeguarding of intangible cultural
heritage in Bosnia and Herzegovina are reflected in all the ethnic
communities that constitute the country. Bosniaks, Serbs and Croats, as well
as members of other communities living in Bosnia and Herzegovina, face a
number of obstacles when it comes to identifying, documenting, protecting
and promoting their heritage. This is due, on the one hand, to the lack of
internal consensus on what is and what is not part of their heritage
(dissonant heritage) and, on the other hand, to the complex arrangement of
heritage that corresponds to the complex constitutional structure of Bosnia
and Herzegovina. This paper uses the heritage of Serbs in Herzegovina as a
case study to illustrate how the lack of support from central authorities,
the weak network of institutional actors and the lack of agreement on
cultural issues complicate the processes related to heritage protection.
This paper aims to provide an incentive for overcoming the challenges and
problems of ICH safeguarding in Bosnia and Herzegovina and to offer some
suggestions for reforming the system to make it more inclusive and provide a
framework for the protection of all citizens and communities living in
Bosnia and Herzegovina.
The issue of expert education and activities in the field of ICH: The example of East Sarajevo
Authors: Guja-Drazeta Zorana
Published: October 2024

Questions about the intangible cultural heritage (ICH) in recent years
represent not only the mere registration, safeguarding, and sustainability
of elements, and the application of the UNESCO Convention, but they also
pose the problem of functioning and (lack of) experts in charge of the
processes above. Considering the complex situation surrounding the overall
political and cultural context of Bosnia and Herzegovina, and thus the
adopted Convention and its application, the issue of education and the work
of experts in the field of protection of the ICH arise. Based on the
?inside? and ?outside? view, the paper will try to draw attention to the
issues of education and the concrete actions of experts who acquired (and
are acquiring) their competencies in different ways. The paper also
emphasizes the evident need for changing/supplementing the educational
programs of the profile of future experts in culture on the example of East
Sarajevo. One of the two existing universities in the Republika Srpska is
located in East Sarajevo, recognized as the ?student? and ?university center
of the eastern part of Srpska?. This area is also rich on musical,
folkloristic, and cultural level, and one element on the preliminary list of
the ICH of Republika Srpska-Bosnia and Herzegovina comes from East Sarajevo.
The aim of the paper is, on the one hand, to point out the problem of
education and the creation of profiles of experts in culture through
different levels of education, and on the other hand, to point out of
activity of artists, (un)official experts and associations in culture,
observed through the prism of ICH in the area of the City of East Sarajevo.
Triage of the immigrants at the golden gate of the promised land: Ellis Island
Authors: Prosic-Dvornic Mirjana
Published: October 2024

Between 1892 and 1954, a center for the reception and processing of
immigrants, who, especially until the First World War, arrived in large
numbers to the USA, was established, under the auspices of the Federal
Government. It was located on the tiny Ellis Island, in New York Harbor,
where the Hudson and East Rivers meet the Atlantic Ocean, in the immediate
vicinity of the Statue of Liberty. Immigrants from Eastern and Southern
Europe dominated, hoping for a better life than the one they had left behind
in their homelands. They were poor, anguished, exhausted and often exiled
people of various nationalities, who had additionally suffered inhumane
conditions as steerage passengers during the ocean crossing since they could
not afford better accommodation. The triage process they were subjected to,
crucial for their fate, told through the history of the center and of
immigrants, but also of employees, reflected the state of American society
in that period: conflicting views on immigration expressed through debates
by politicians, experts and members of the academic community, opinions of
business circles and the emerging labor unions, writings of the free press
and the public opinion, greatly manipulated by groups interested in their
own welfare, the passing of legal regulations and their implementation. All
this determined the future of the newcomers: would they pass through the
Golden Gate to the Promised Land, or would they be deported from the Isle of
Tears back to their country of origin? Who was considered eligible to be
accepted to the American society, and who was deemed undesirable and even
dangerous and therefore rejected? From the immigrants? point of view, the
overseas trip to America and the stay on Ellis Island represented a liminal
phase of this crucial rite of passage in their lives, and it is estimated
that over 25% and even up to 40% of today?s Americans are the descended of
the twelve million settlers who passed through the center during that
period.
Community mapping methodology - researching the heritage of the Romani women emancipation
Authors: Djordjevic Marija , Bogdanovic Bojana , Rasic Milos
Published: October 2024

This paper presents the relatively new - in local framework of humanities
rarely applied - method of community mapping is introduced and explored.
Community mapping is a participatory research approach that focuses on the
needs of social groups, that are evaluated and holistically understood in
the process; and used as a ground for designing policies for the further
development of community research. The main case study of the analysis is
the project - ?HEROINES: Heritage of Emancipation - Empowering Roma Women
through Networks of Solidarity?, implemented by Institute of Ethnography
SASA, Roma Women Center ?Bibija? and the Faculty of Philosophy, University
of Belgrade. The project is supported by the Center for the Promotion of
Science (CPN). This citizen?s research project uses community mapping as its
main method, with Roma women - as simultaneously marginal and marginalized
in the broader society - being the main target group and the main
representative of the other in their social reality.
Eighteen-Month Hybrid Closed-Loop Use in Very Young Children With Type 1 Diabetes: A Single-Arm Multicenter Trial
Authors: Ware Julia , Allen Janet M. , Boughton Charlotte K. , Wilinska Malgorzata E. , Hartnell Sara , Thankamony Ajay , de Beaufort Carine , Campbell Fiona M. , Fröhlich-Reiterer Elke , Fritsch Maria , Hofer Sabine E. , Kapellen Thomas M. , Rami-Merhar Birgit , Tauschmann Martin , Hovorka Roman ,   KidsAP Consortium, Hovorka Roman , Acerini Carlo L , Thankamony Ajay , Boughton Charlotte K , Dovc Klemen , Ware Julia , Musolino Gianluca , Wilinska Malgorzata E , Allen Janet M , Hartnell Sara , Ruan Yue , Ashcroft Nicole , Haydock Matthew , Hill Catherine , Fritsch Maria , Jasser-Nitsche Hildegard , Mader Julia K , Faninger Kerstin , Kapellen Thomas M , Bartelt Heike , Thiele Alena , Rami-Merhar Birgit , Berger Gabriele , Blauensteiner Nicole , Gellai Renata , Nagl Katrin , Tauschmann Martin , Cvach Sarah , Katzenbeisser-Pawlik Sonja , Hofer Sabine E , Abt Daniela , Malik Anita , Lanthaler Barbara , Wenzel Matthias , Campbell Fiona , Yong James , Metcalfe Emily , Allen Majorie , Ambler Sarah , Waheed Saima , Exall Jane , Tulip Joseph , de Beaufort Carine , Schierloh Ulrike , Fichelle Muriel , Schaeffer Dominique , Lawton Julia , Rankin David , Hart Ruth , Kimbell Barbara , Roze Stéphane , Jones Timothy , Patterson Chris , Adolfsson Peter
Published: October 2024

OBJECTIVE

We aimed to evaluate the longer-term safety and efficacy of hybrid closed-loop (CL) therapy in very young children with type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS

Following a 16-week multinational, randomized crossover trial comparing hybrid CL with sensor-augmented pump (SAP) therapy in 74 very young children aged 1–7 years with T1D, participants were invited to an extension phase using CL for a further 18 months. Outcomes were compared with the primary-phase SAP period and primary-phase CL period.

RESULTS

After the primary study phase, 60 participants were eligible to enroll in the extension. Of these, 49 consented (mean ± SD age 6.6 ± 1.5 years) to continue use of CL for 18 months. Percentage time in range (TIR) 3.9–10.0 mmol/L was 8.4 percentage points (95% CI 6.7–10.1; P < 0.001) higher, while HbA1c was 0.4% ([5.0 mmol/mol], 95% CI 0.3–0.6 [3.7–6.2]; P < 0.001) lower during the CL extension phase compared with primary-phase SAP period. At 18 months, mean HbA1c was 6.7 ± 0.5% and TIR was 70 ± 7%, compared with 6.7 ± 0.5% and 71 ± 6% in the primary-phase CL period. Time in hypoglycemia (<3.9 mmol/L) was similar between CL extension phase and both primary-phase SAP (P = 0.31) and CL periods (P = 0.70). There were two severe hypoglycemia events and one other serious adverse event during the extension phase. One unexpected serious adverse device effect occurred.

CONCLUSIONS

Use of the Cambridge hybrid CL system led to sustained improvements in glycemic control lasting more than 18 months in very young children with T1D.
UNIQUE BETA-LIKE DNA POLYMERASE FROM ХРОМАТИН OF HUMAN ACUTE MYELOID LEUKEMIA HL-60 CELLS
Authors: Buchvostov A. A , Orlov A. P , Shatalov O. A , Kusnetsov D. A
Published: October 2024

Human acute myeloid leukemia cells HL-60 over expresses a beta-like DNA polymerase (EC 2.7.7.7) which is found to be a chromatin associated single subunit protein (66.5 kDa) purified by original extraction/gel filtration procedure allowing to gain the 122,000-fold purification degree as corrected to a total cell protein. The enzyme possesses some key DNA pol р-specific catalytic properties such as the processing of short (200-250 n) single strand DNA sequences, activation in the presence of 200 mMKCl, resistance to N-ethyl-melamide and Aphidicolin, lack of 3',5'-exonuclease activity. A possible significance of the unique enzyme studied as a target for its pharmaceutical inhibitors is under discussion.
To the 90th year of Alexandr Jakovlevich Friedenstein
Authors: Zorin V. L , Zorina A. I
Published: October 2024

The article is dedicated to the outstanding Russian scientist A.J. Friedenstein, a founder of the hematopoietic organs' stroma doctrine, a discoverer of mesenchymal stem cells (multipotent mesenchymal stromal cells, MMSC), an initiator of the tests to determine the «verity» of stem stromal cells. Discoveries of the scientist and scientific school he created are used both in the research and clinical practice all over the world.
Chondroitinsulfate proteoglycan receptors in the nervous system
Authors: Paveliev M. N , Baltina TY. V
Published: October 2024

Chondroitinsulfate proteoglycans (CSPG) play a crucial role in the inhibition of posttraumatic axonal regeneration in the central nervous system. Understanding of the mechanism of the CSPG action on axonal regeneration is important for treatment of patients after the brain and spinal cord injuries. Here we make a review of recent studies that discovered CSPG receptors acting in the plasma membrane of neurons.
Replacement of the anterior-lateral wall of the maxillary sinus with allografts
Authors: Shcherbakov D. A , Lebedeva A. I , Karimova A. I
Published: October 2024

The aim of the work was a comparative experimental and clinical study of efficacy of the bone and cartilage allografts in restoration of defects in the anterior-lateral wall of the maxillary sinus. Experimental studies were performed on rabbits Chinchilla. After modeling the defect of the anterior wall of the maxillary sinus the grafting was performed with cartilage allografts in the first experimental group (n = 12), in the second group (n = 12) - bone allograft was used as a biomaterial. In the clinical part of the study we evaluated the effectiveness of treatment in patients after maxillotomy with the reconstruction of the anterior-lateral wall with the cartilage (n = 21) or bone (n = 24) allografts. We found that both types of allografts induced reparative osteogenesis in the field of bone defect. Some features in regeneration process depending on the type of biomaterial were shown. Clinical studies demonstrated the efficacy of the cartilage and the bone allografts in replacement of the anterior-lateral wall of the maxillary sinus. In all cases a positive clinical outcome, the integrity of the anterior-lateral wall of the sinus, was achieved. Both allografts were replaced by lamellar bone tissue and that's why could be considered as an alternative of autogenous bone transplants in such operations. In patients with dolichocephalic skull and deep canine fossa it is appropriate to use the cartilage allografts characterized by higher elastic properties.
Complement system d-inhibitor at newborns of intrauterine infection development risk group
Authors: Zhdanova S. I , Bikmullina Z. M , Kozlov L. V , Bulatov V. P , Gora N. V , Andina S. S , Zhdanov R. I
Published: October 2024

Complement system is considered as unspecific defence system of human organism, which starts to function just after born. The state of complement system at newborns including C1 inhibitor data is less studied. The paper is aimed to study functional activity and contents of C1 inhibitor in blood of newborn infants (taken on 3-5 day of life), their mothers and umbilical blood as well from group of the risk of development of mycoplasma and ureaplasma infections. Totally 105 blood samples taken from newborn infants and their mothers of risk group were analysed based on occasional selection approach. Ten healthy newborn infants without risk of intrautero infection development and their mothers were used as a control group. Complement C1 inhibitor functional activity and contents is studied by immune enzyme assay using ELISA. C1 inhibitor activity and blood contents at newborn infants from mothers of infection risk group is higher compare to newborn infants from healthy mothers. Infection agent induces C1 activity more than its content at mother blood, due to higher turnover of this protein. It is approved the increased C1 activity at newborn blood of control group (p = 0,009) and of mothers of risk group (р = 0,0009) compare to umbilical blood. The mothers' blood is characterized with very high level of C1 content and functional activity many times higher than normal values which is specific to the acute phase state of the organism during the born process. C1 content at umbilical cord blood is 4-fold less than at mothers blood which testifies an existence of blood-brain barrier for C1 inhibitor.
Genetic effects of medicines - lipid exchange modulators
Authors: Ibragimova M. Y , Semenov V. V , Kh Ibragimov Ya. Kh , Validov Sh. Z , Zhdanov R. I
Published: October 2024

There are medicines known as adrenoreceptors ligands, which influences a variety of lipid exchange, therefore the study of their mutagenic and antimutagenic potentials, their genotoxicity, is of great interest. The study are fullfiled using C57B4/6 mice (males) of 20 g and 1,5-2 months of age. Mutagenic and antimutagenic effects of the ligands were evaluated using in vivo tests: mouse brain skeleton cells (a number of chromosomal aberrations) and mouse peripheral red blood cells peripheral (a number of cells with micronuclei from 2000 analyzed cells). 6 male mice were used for every experimental and control variant. All medicines studied - epinephrine, phenylephrine, orciprenalin, proroxan, and propranolol (besides epinephrine, 50 mg/kg) - in a majority of doses used don't increase the level of chromosomal aberrations and the number of red blood cells with micronuclei.Epinephrin, phenylephrine, orciprenalin in doses studied demonstrated a protector effect and decreased a level of chromosomal aberrations and a number of red blood cells with micronuclei induced by cyclophosphamide administration. Proroxan and propranolol didn't change a level of aberrations. It was shown that adrenoreceptor ligands decreasing or increasing lipid level did not express mutagenic effect, and, in opposite, expressed antimutageni which testify that the system participating simultaneously in a realization of lipid exchange and mutagenesis/ antimutagenesis exists. An action of the system is realized via cell membrane receptors. According mechanism of action, the system is polyreceptoric (a- and р-adrenoreceptors take a part) and polyvalent, namely, receptor stimulators and blocators take a part in a formation of cell antimutagenesis.
Application of genetically modified umbilical cord blood cells and direct gene therapy for treatment of skin wounds in rats
Authors: Gazizov I. M , Salafutdinov I. I , Mavlikeev M. O , Bashirov F. V , Islamov R. R , Rizvanov A. A , Kiassov A. P
Published: October 2024

There were proposed several methods for stimulation of skin wound repair over the last few decades. The most perspective among them are gene and stem cell therapy. In our experiments we combined both approaches by application of human cord blood mononuclear cells (hUCB-MC) transfected with pBud-VEGF165-FGF2 plasmid to enhance healing of full thickness skin wounds in rats. Dual expression cassette plasmid pBud-VEGF165-FGF2 encodes both VEGF and FGF2 therapeutic genes, expressing pro-angiogenic growth factors. Our results showed that in 2 weeks after transplantation some transplanted cells still retain expression of stem cell and hematopoietic markers C-kit and CD34. Other transplanted cells could be found among keratinocytes, hair follicle cells, endothelial cells and in derma. Study of PCNA expression revealed that application of transfected cells terminate proliferative processes in regenerating wound earlier then application of untransfected cells.
Investigation of recombinant therapeutic genes expression in umbilical cord blood mononuclear cells transduced with three adenoviral vectors encoding neurotrophic factors GDNF, VEGF and neural cell adhesion molecule NCAM
Authors: Islamov R. R , Rizvanov A. A , Cherenkova E. E , Mukhamedshina Y. O , Salafutdinov I. I , Safiullov Z. Z , Izmailov A. A , Mukhamedyarov M. A , Guseva D. S
Published: October 2024

To overcome the effects of neurodegeneration and stimulating neuroregeneration in the spinal cord transgenic mice with model of amyotrophic lateral sclerosis were injected intraspinally with umbilical cord blood mononuclear cells (UCBMCs) transduced with adenoviral vectors encoding for vascular endothelial growth factor, glia-derived neurotrophic factor and neural adhesion molecule. Two weeks after transplantation UCBMCs were localized in the site of injection and at a distance from it, confirming the migration capacity of the cells in spinal cord parenchyma. Using triple immunofluorescence staining UCBMCs expressing therapeutic genes were found. The study results suggest the expedience of given gene-cell construct to stimulate the neuroregeneration in central nervous system after neurotrauma, ischemic stroke and in neurodegenerative diseases.