bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Reliability of Prediction Results of Mine Surface Subsidence of Northern Pei County for Reusing Land Resources
Authors: Yuan Yafei , Li Huaizhan , Zhang Haojie , Zhang Yiwei , Zhang Xuewei
Published: November 2020

The accurate prediction of mine surface subsidence is directly related to the reuse area of land resources. Currently, the probability integral method is the most extensive method of surface subsidence prediction in China. However, its prediction precision largely depends on the accuracy of the selected parameters. When the mining area lacks measured data, or the geological and mining conditions change, particularly for large-scale surface subsidence prediction, the reliability of the prediction of surface subsidence is poor. Moreover, there is a lack of a systematic summary of the correct selection of prediction parameters. Based on this, the paper systematically investigated the influence of geological and mining conditions on the prediction parameters of the probability integral method. The research findings were obtained via theoretical analysis. The research outcomes can provide a scientific basis for properly selecting the prediction parameters of the probability integral method. Last, the results of this paper can be applied to predict the surface subsidence of Pei County in the north, laying the foundation for the integration of Pei County.
Table Organization Optimization in Schools for Preserving the Social Distance during the COVID-19 Pandemic
Authors: Ferrero-Guillén Rubén , Díez-González Javier , Verde Paula , Álvarez Rubén , Perez Hilde
Published: November 2020

The COVID-19 pandemic has supposed a challenge for education. The school closures during the initial coronavirus outbreak for reducing the infections have promoted negative effects on children, such as the interruption of their normal social relationships or their necessary physical activity. Thus, most of the countries worldwide have considered as a priority the reopening of schools but imposing some rules for keeping safe places for the school lessons such as social distancing, wearing facemasks, hydroalcoholic gels or reducing the capacity in the indoor rooms. In Spain, the government has fixed a minimum distance of 1.5 m among the students’ desks for preserving the social distancing and schools have followed orthogonal and triangular mesh patterns for achieving valid table dispositions that meet the requirements. However, these patterns may not attain the best results for maximizing the distances among the tables. Therefore, in this paper, we introduce for the first time in the authors’ best knowledge a Genetic Algorithm (GA) for optimizing the disposition of the tables at schools during the coronavirus pandemic. We apply this GA in two real-application scenarios in which we find table dispositions that increase the distances among the tables by 19.33% and 10%, respectively, with regards to regular government patterns in these classrooms, thus fulfilling the main objectives of the paper.
A Rapid Colorimetric Assay for On-Site Authentication of Cephalopod Species
Authors: Tatulli Giuseppina , Cecere Paola , Maggioni Davide , Galimberti Andrea , Pompa Pier Paolo
Published: November 2020

A colorimetric assay, exploiting the combination of loop-mediated isothermal amplification (LAMP) with DNA barcoding, was developed to address the authentication of some cephalopod species, a relevant group in the context of seafood traceability, due to the intensive processing from the fishing sites to the shelf. The discriminating strategy relies on accurate design of species-specific LAMP primers within the conventional 5’ end of the mitochondrial COI DNA barcode region and allows for the identification of Loligo vulgaris among two closely related and less valuable species. The assay, coupled to rapid genomic DNA extraction, is suitable for large-scale screenings and on-site applications due to its easy procedures, with fast (30 min) and visual readout.
Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology
Authors: Becchetti Andrea , Grandi Laura Clara , Colombo Giulia , Meneghini Simone , Amadeo Alida
Published: November 2020

Sleep-related hypermotor epilepsy (SHE) is characterized by hyperkinetic focal seizures, mainly arising in the neocortex during non-rapid eye movements (NREM) sleep. The familial form is autosomal dominant SHE (ADSHE), which can be caused by mutations in genes encoding subunits of the neuronal nicotinic acetylcholine receptor (nAChR), Na+-gated K+ channels, as well as non-channel signaling proteins, such as components of the gap activity toward rags 1 (GATOR1) macromolecular complex. The causative genes may have different roles in developing and mature brains. Under this respect, nicotinic receptors are paradigmatic, as different pathophysiological roles are exerted by distinct nAChR subunits in adult and developing brains. The widest evidence concerns α4 and β2 subunits. These participate in heteromeric nAChRs that are major modulators of excitability in mature neocortical circuits as well as regulate postnatal synaptogenesis. However, growing evidence implicates mutant α2 subunits in ADSHE, which poses interpretive difficulties as very little is known about the function of α2-containing (α2*) nAChRs in the human brain. Planning rational therapy must consider that pharmacological treatment could have different effects on synaptic maturation and adult excitability. We discuss recent attempts towards precision medicine in the mature brain and possible approaches to target developmental stages. These issues have general relevance in epilepsy treatment, as the pathogenesis of genetic epilepsies is increasingly recognized to involve developmental alterations.
Analysis and Model-Based Description of the Total Process of Periodic Deactivation and Regeneration of a VOx Catalyst for Selective Dehydrogenation of Propane
Authors: Brune Andreas , Seidel-Morgenstern Andreas , Hamel Christof
Published: November 2020

This study intends to provide insights into various aspects related to the reaction kinetics of the VOx catalyzed propane dehydrogenation including main and side reactions and, in particular, catalyst deactivation and regeneration, which can be hardly found in combination in current literature. To kinetically describe the complex reaction network, a reduced model was fitted to lab scale experiments performed in a fixed bed reactor. Additionally, thermogravimetric analysis (TGA) was applied to investigate the coking behavior of the catalyst under defined conditions considering propane and propene as precursors for coke formation. Propene was identified to be the main coke precursor, which agrees with results of experiments using a segmented fixed bed reactor (FBR). A mechanistic multilayer-monolayer coke growth model was developed to mathematically describe the catalyst coking. Samples from long-term deactivation experiments in an FBR were used for regeneration experiments with oxygen to gasify the coke deposits in a TGA. A power law approach was able to describe the regeneration behavior well. Finally, the results of periodic experiments consisting of several deactivation and regeneration cycles verified the long-term stability of the catalyst and confirmed the validity of the derived and parametrized kinetic models for deactivation and regeneration, which will allow model-based process development and optimization.
The Role of Endoscopic Ultrasound for Esophageal Varices
Authors: Nagashima Kazunori , Irisawa Atsushi , Tominaga Keiichi , Kashima Ken , Kunogi Yasuhito , Minaguchi Takahito , Izawa Naoya , Yamamiya Akira , Yamabe Akane , Hoshi Koki , Goda Kenichi , Iijima Makoto
Published: November 2020

Esophageal varices are caused by the development of collateral circulation in the esophagus as a result of portal hypertension. It is important to administer appropriate preventive treatment because bleeding varices can be fatal. Esophageal varices have complex and diverse hemodynamics, and there are various variations for each case. Endoscopic ultrasound (EUS) can estimate the hemodynamics of each case. Therefore, observation by EUS in esophageal varices provides useful information, such as safe and effective treatment selection, prediction of recurrence, and appropriate follow-up after treatment. Although treatment for the esophagogastric varices can be performed without EUS imaging, understanding the local hemodynamics of the varices using EUS prior to treatment will lead to more safe and effective treatment. EUS observation is an indispensable tool for thorough variceal care.
Impact of Global Warming in Subtropical Climate Buildings: Future Trends and Mitigation Strategies
Authors: Videras Rodríguez Marta , Sánchez Cordero Antonio , Gómez Melgar Sergio , Andújar Márquez José Manuel
Published: November 2020

The growing concern about global climate change extends to different professional sectors. In the building industry, the energy consumption of buildings becomes a factor susceptible to change due to the direct relationship between the outside temperature and the energy needed to cool and heat the internal space. This document aims to estimate the energy consumption of a Minimum Energy Building (MEB) in different scenarios—past, present, and future—in the subtropical climate typical of seaside cities in Southern Spain. The building energy consumption has been predicted using dynamic building energy simulation software tools. Projected climate data were obtained in four time periods (Historical, the 2020s, 2050s, and 2080s), based on four emission scenarios defined by the Intergovernmental Panel on Climate Change (IPCC): B1, B2, A2, A1F1. This methodology has been mathematically complemented to obtain data in closer time frames (2025 and 2030). In addition, different mitigation strategies have been proposed to counteract the impact of climate change in the distant future. The different energy simulations carried on show clearly future trends of growth in total building energy consumption and how current building designers could be underestimating the problem of air conditioning needs in the subtropical zone. Electricity demand for heating is expected to decrease almost completely, while electricity demand for cooling increases considerably. The changes predicted are significant in all scenarios and periods, concluding an increase of between 28–51% in total primary energy consumption during the building life cycle. The proposed mitigation strategies show improvements in energy demands in a range of 11–14% and they could be considered in the initial stages of project design or incorporated in the future as the impact of climate change becomes more pronounced.
Building and Urban Cooling Performance Indexes of Wetted and Green Roofs—A Case Study under Current and Future Climates
Authors: Kaboré Madi , Bozonnet Emmanuel , Salagnac Patrick
Published: November 2020

We developed and studied key performance indexes and representations of energy simulation heat fluxes to evaluate the performance of the evaporative cooling process as a passive cooling technique for a commercial building typology. These performance indexes, related to indoor thermal comfort, energy consumption and their interactions with their surrounding environments, contribute to understanding the interactions between the urban climate and building for passive cooling integration. We compare the performance indexes for current and future climates (2080), according to the highest emission scenario A2 of the Special Report on Emission Scenario (SRES). Specific building models were adapted with both green roof and wetted roof techniques. The results show that summer thermal discomfort will increase due to climate change and could become as problematic as winter thermal discomfort in a temperate climate. Thanks to evapotranspiration phenomena, the sensible heat contribution of the building to the urban heat island (UHI) is reduced for both current and future climates with a green roof. The performance of the vegetative roof is related to the water content of the substrate. For wetted roofs, the impacts on heat transferred to the surrounding environment are higher for a Mediterranean climate (Marseille), which is warmer and drier than the Paris climate studied (current and future climates). The impact on indoor thermal comfort depends on building insulation, as demonstrated by parametric studies, with higher effects for wetted roofs.
PCM-Based Energy Storage System with High Power Output Using Open Porous Aluminum Foams
Authors: Baumeister Joachim , Weise Jörg , Myslicki Sebastian , Kieseritzky Esther , Lindenberg Götz
Published: November 2020

Thermal comfort (heating, ventilation and air conditioning, HVAC) and the energy consumption involved with it can put a strain on the driving range of fully electric vehicles (FEV), especially in certain times of the year as midsummer or winter. In order to reduce the energy consumption of HVAC, improved thermal management and adapted means of energy storage are needed. One part of the solution can be the use of phase change materials (PCM) for storing waste heat. For the specific application, however, a high loading/unloading power rate is required, which is challenging as the PCMs exhibit low heat conductivities. In the presented work, a storage demonstrator system was investigated which is part of an HVAC system of a specific fully electric vehicle. The profile of requirements of the system (power, stored capacity and allowed volume) make a new design of the storage necessary. Two demonstrator units, in which the PCM was combined with aluminum foam, were manufactured and their power output in dependency on the fluid flow of the coolant system was compared. An adapted squeeze casting process with polymer placeholders was used for the production of the aluminium foam. This process results in foams with a specific pore structure and allows the in-situ integration of the heat transfer fluid (HTF) pipes. Both newly developed PCM storage systems satisfy the HVAC system requirements.
Network Characteristics and Vulnerability Analysis of Chinese Railway Network under Earthquake Disasters
Authors: Yin Lingzhi , Wang Yafei
Published: November 2020

The internal structure and operation rules of railway network have become increasingly complex along with the expansion of the network, putting a higher demand on the development of the railway and the reliability and adaptability of the railway under earthquake disasters. The theory and method concerning complex railway network can well capture the internal structure of railway facilities system and the relationship between subsystems. However, most of the research focuses on the vulnerability based on the logical network of railway, deviating from the actual spatial location of railway network. Additionally, only random attacks and deliberate attacks are factored in, ignoring the impact of earthquake disasters on actual railway lines. Therefore, this paper built a geographic railway network and analyzed topological structure of the network and its vulnerability under earthquake disasters. First, the geographic network of Chinese railway was built based on the methods of complex network, linear reference and dynamic segmentation. Second, the spatial distribution of railway network flow was analyzed by node degree, betweenness and clustering coefficient. Finally, the vulnerability of the geographic railway network in areas with high seismic hazards were assessed, aiming to improve the capacity to prevent and resist earthquake disasters.
Modeling Spatial Charging Demands Related to Electric Vehicles for Power Grid Planning Applications
Authors: Gauglitz Philip , Ulffers Jan , Thomsen Gyde , Frischmuth Felix , Geiger David , Scheidler Alexander
Published: November 2020

The electrification of the transport sector together with an increasing share of renewable energies has the potential to reduce CO2 emissions significantly. This transformation requires the rollout of charging infrastructure, which has an impact on power grids. For grid planning and dimensioning purposes, it is crucial to assess this rapidly growing impact. We present an approach using socio-economic data such as income levels together with a model for demographic changes to estimate where electric mobility is likely to be concentrated, especially during the transformation phase. We present a total-cost-of-ownership approach for the ramp-up of electric mobility, considering an increased penetration of renewable energies. With the city of Wiesbaden in Germany as an example for an application area, the possible expansion of vehicle ownership and charging points is modeled on the level of individual buildings. Compared to a simpler approach, the detailed model results in more consistent charging point allocations, higher line/transformer loadings and lower bus voltages for the investigated grids. Predicting future distributions of charging points with such a level of detail in terms of ramp-up and spatial resolution proves potentially beneficial for grid analysis and planning purposes, especially in urban areas, where infrastructure changes are expensive and time-consuming.
An Interdisciplinary Scientific and Mathematic Education, Addressing Relevant Social Problems Such as Sexist Hate Speech
Authors: Sánchez-Compaña M.ª Teresa , Sánchez-Cruzado Cristina , García-Ruiz Carmen Rosa
Published: November 2020

The intention of this article is to share research taken from the initial training of secondary education pre-service teachers, in which college professors from mathematics and social sciences education participate. There are numerous studies regarding curriculum integration. However, there is insufficient research that offers insight into how different forms of disciplinary thought may come together in the design and development in practice for an educational purpose. The research professors carried out a qualitative investigation, working with two pre-service teacher groups from the fields of mathematics and social sciences. We used a validated research instrument to analyze how interdisciplinary educational proposals are developed, and how said proposals can be used to understand our social reality. Through an integrated project, pre-service teachers addressed sexist hate speech taken from different contexts. They designed didactic proposals, with mathematical contents, which allow high school students to argue with data and create counter-narratives, which softened or eliminated the sexist hate speech Among the conclusions, we may emphasize the value of pre-service teachers identifying their strengths in order to use the mathematical and social thought processes in an autonomous and creative way, thereby developing the instrumental, functional, and formative character in mathematics education.
Best Procedure for the Management of Common Bile Duct Stones via the Papilla: Literature Review and Analysis of Procedural Efficacy and Safety
Authors: Ishii Shigeto , Isayama Hiroyuki , Ushio Mako , Takahashi Sho , Yamagata Wataru , Takasaki Yusuke , Suzuki Akinori , Ochiai Kazushige , Tomishima Ko , Kanazawa Ryo , Saito Hiroaki , Fujisawa Toshio , Shiina Shuichiro
Published: November 2020

Background: Endoscopic management of common bile duct stones (CBDS) is standard; however, various techniques are performed via the papilla, and the best procedure in terms of both efficacy and safety has not been determined. Methods: Endoscopic procedures were classified into five categories according to endoscopic sphincterotomy (EST) and balloon dilation (BD): (1) EST, (2) endoscopic papillary BD (≤10 mm) (EPBD), (3) EST followed by BD (≤10 mm) (ESBD), (4) endoscopic papillary large BD (≥12 mm) (EPLBD), and (5) EST followed by large BD (≥12 mm) (ESLBD). We performed a literature review of prospective and retrospective studies to compare efficacy and adverse events (AEs). Each procedure was associated with different efficacy and AE profiles. Results: In total, 19 prospective and seven retrospective studies with a total of 3930 patients were included in this study. For EST, the complete stone removal rate at the first session, rate of mechanical lithotripsy (ML), and rate of overall AEs in EST were superior to EPBD, but a higher rate of bleeding was found for EST. Based on one retrospective study, complete stone removal rate at the first session, rate of ML, and rate of overall AEs were superior for ESBD vs. EST, and the rate of bleeding for the former was also lower. Complete stone removal rate at the first session and rate of ML for ESLBD were superior to those for EST, with no significant difference in rate of AEs. For EST vs. EPLBD, complete stone removal rate at the first session and rate of ML were superior for the latter. For EPLBD vs. ESLBD, the efficacy and safety were similar. Conclusions: ESBD is considered the best procedure for the management of small CBDS, but strong evidence is lacking. For large CBDS, both ESLBD and EPLBD are similar.
Wernicke’s Encephalopathy in Alcohol Use Disorder Patients after Liver Transplantation: A Case Series and Review of Literature
Authors: Vassallo Gabriele , Mirijello Antonio , Dionisi Tommaso , Tarli Claudia , Augello Giuseppe , Gasbarrini Antonio , Addolorato Giovanni ,   on behalf of the Gemelli OLT Group
Published: November 2020

Wernicke’s encephalopathy (WE) is an acute neurological disorder resulting from thiamine deficiency, commonly found in alcohol use disorder (AUD) patients. Liver transplantation (LT) could represent a risk factor for the onset of WE in AUD patients, due to the onset of chronic depletion of thiamine in this population and the high metabolic demand of surgery and the postoperative period. However, few data are available about the risk of the onset of WE in AUD patients after LT. Here we report three cases of AUD patients who developed WE with confusion and delirium after LT. Prompt parenteral administration of thiamine led to a rapid improvement of the clinical condition and a complete remission of neurological symptoms after 3–4 days. In addition, a search of the available English literature was conducted in order to perform a review of the possible association between the onset of WE and LT in AUD patients. A prophylactic treatment regimen based on the administration of thiamine could be suggested in AUD patients before and after LT. Further studies are needed to determine the optimal regimen of thiamine in the prevention of WE in this setting.
Arginine and Arginine/ADMA Ratio Predict 90-Day Mortality in Patients with Out-of-Hospital Cardiac Arrest—Results from the Prospective, Observational COMMUNICATE Trial
Authors: Keller Annalena , Becker Christoph , Nienhaus Katharina , Beck Katharina , Vincent Alessia , Sutter Raoul , Tisljar Kai , Schuetz Philipp , Bernasconi Luca , Neyer Peter , Pargger Hans , Marsch Stephan , Hunziker Sabina
Published: November 2020

(1) Background: In patients with shock, the L-arginine nitric oxide pathway is activated, causing an elevation of nitric oxide, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels. Whether these metabolites provide prognostic information in patients after out-of-hospital cardiac arrest (OHCA) remains unclear. (2) Methods: We prospectively included OHCA patients, recorded clinical parameters and measured plasma ADMA, SDMA and Arginine levels by liquid chromatography tandem mass spectrometry (LC-MS). The primary endpoint was 90-day mortality. (3) Results: Of 263 patients, 130 (49.4%) died within 90 days after OHCA. Compared to survivors, non-survivors had significantly higher levels of ADMA and lower Arginine and Arginine/ADMA ratios in univariable regression analyses. Arginine levels and Arginine/ADMA ratio were significantly associated with 90-day mortality (OR 0.51 (95%CI 0.34 to 0.76), p < 0.01 and OR 0.40 (95%CI 0.26 to 0.61), p < 0.001, respectively). These associations remained significant in several multivariable models. Arginine/ADMA ratio had the highest predictive value with an area under the curve (AUC) of 0.67 for 90-day mortality. Results for secondary outcomes were similar with significant associations with in-hospital mortality and neurological outcome. (4) Conclusion: Arginine and Arginine/ADMA ratio were independently associated with 90-day mortality and other adverse outcomes in patients after OHCA. Whether therapeutic modification of the L-arginine-nitric oxide pathway has the potential to improve outcome should be evaluated.
Multilevel Analysis of the Pressure of Agricultural Land Conversion, Degree of Urbanization and Agricultural Land Prices in Taiwan
Authors: Lee Chun-Chang , Chen Yi-Xin , Wu Yun-Ling , Yeh Wen-Chih , Liang Chih-Min
Published: November 2020

In 2000, to efficiently implement land-use policies, the Taiwanese government amended the Agricultural Development Act by easing restrictions on agricultural land purchases. As a result of increasing land development and investment needs, agricultural land prices have surged. This study aims to examine whether agricultural land prices in Pingtung County are affected by land control policy measures, the pressure of agricultural land conversion and the degree of urbanization. A multilevel analysis approach was used to analyze land price differences in townships in Pingtung County. The estimation results derived from the null model indicated significant differences between the mean land price in each administrative division. Specifically, the ratio of agricultural land prices affected by differences in Level 2 township-related factors was 21.8%, while the ratio of those affected by differences in Level 1 land-related factors was 78.2%. An empirical intercepts-and-slopes-as-outcomes regression model demonstrated that Level 2 township-related factors, such as the pressure of agricultural land conversion and the degree of urbanization, had cross-level, direct and positive impacts on agricultural land prices; while Level 1 land-related factors, such as lot size control measures on farmhouse construction and land-use zoning, had positive and significant impacts on agricultural land prices.
Cavitation Model Calibration Using Machine Learning Assisted Workflow
Authors: Sikirica Ante , Čarija Zoran , Lučin Ivana , Grbčić Luka , Kranjčević Lado
Published: November 2020

Conventional cavitation assessment methodology in industrial and scientific applications generally depends on cavitation models utilizing homogeneous mixture assumption. These models have been extensively assessed, modified and expanded to account for deficiencies of their predecessors. Unfortunately, none of the proposed models can be classified as the universal solution for all engineering applications, with usage mainly directed by experience or general availability of the models. In this study we propose a workflow through which the empirical constants governing the phase change of the Kunz mixture cavitation model can be calibrated for a given application or a series of problems, with machine learning as a tool for parameter estimation. The proposed approach was validated on a three-dimensional propeller test case with results in excellent agreement for the case in question. Results for thrust and torque were within 2% with cavity extents differing by up to 20%. This is a significant improvement when compared to previously proposed parameters. Despite the lack of generalization due to the limited nature of the dataset on which the model was trained, the proposed parameters entail acceptable results for similar cases as well. The overall methodology is applicable to other problems as well and should lead to more accurate cavitation predictions.
Levels of Physical Activity in Spanish Asthmatics: A Cross-Sectional Study
Authors: Sánchez Castillo Sheila , Smith Lee , Díaz Suárez Arturo , López Sánchez Guillermo Felipe
Published: November 2020

Background and objectives: 339 million people in the world suffer from asthma. Regular physical activity (PA) could help in its control. Therefore, the aim of this research was to determine the level of PA in Spanish people with asthma considering variation by, age, sex, education, marital status, living together, smoking habits, alcohol intake and body mass index (BMI). Materials and Methods: 1014 Spanish people from 15 to 69 years were included in the study. Data of the Spanish Health Survey (year 2017) were analysed. PA levels were measure with the international physical activity questionnaire short version (IPAQ-SF). PA was categorized as low, moderate and high, and analyzed by sample characteristics. Mann-Whitney U test, Kruskall Wallis H and crosstabs were used to calculate statistical significance (p < 0.05). Results: On average, Spanish asthmatics engaged in a weekly volume of 2228.9 metabolic equivalent of task (MET)·min/week. Males revealed significantly higher PA than females (2516.8 vs. 2019.5 MET·min/week; p = 0.005), younger participants (<30 years) compared to people aged 30–60 years and older than 60 years (2699.0; 2243.2; 1619.3 MET·min/week; p < 0.001) and those with tertiary level of education than those without secondary (2368.3 vs. 2168.3 MET·min/week; p = 0.001). Level of PA was lower in those married (p = 0.001) and/or living together (p = 0.010). Alcohol consumers showed a higher level than the participants who did not drink (2378.3 vs. 1907.9 MET·min/week; p = 0.001), but no significant differences were found within current, past and never smokers (p = 0.890). Obese asthmatics engaged in less PA than their normal weight and overweight peers (p < 0.001). Overall, moderate level was significantly the most frequent (47.7%), but 31.6% showed a low level. Conclusions: Three out of ten Spanish people with asthma do not achieve PA recommendations, so PA programs should be executed to make people aware of its benefits in asthma control, focusing on those groups with lower PA levels.
Pivoting Dental Practice Management during the COVID-19 Pandemic—A Systematic Review
Authors: Mahdi Syed Sarosh , Ahmed Zohaib , Allana Raheel , Peretti Alessandro , Amenta Francesco , Nadeem Bijle Mohammed , Seow Liang Lin , Daood Umer
Published: November 2020

Background and Objectives: The aims of this systematic review were to identify additional infection control measures implemented in dental practice globally to prevent cross-infection and evaluate the psychological impacts of the pandemic among dental professionals. Materials and Methods: A sequential systematic literature search was conducted from December 2019 to 30 April 2020 through PubMed, CINAHL, Scopus, Google Scholar, Embase, and Web of Science databases. The search yielded the following results: “COVID-19” (n = 12,137), “Novel corona virus” (n = 63), “COVID-19 and dentistry” (n = 46), “COVID-19 and oral health” (n = 41), “Novel Corona virus and Dentistry” (n = 0), “dental health and Novel Coronavirus” (n = 26), and “dental practice and Novel Coronavirus” (n = 6). Results: After a careful review and eliminating articles based on inclusion and exclusion criteria, the final review included 13 articles. Management of infection control is discussed extensively in the literature and remains the main theme of many Coronavirus Disease 2019 (COVID-19) articles on dentistry. Telephone triage using a questionnaire, hand hygiene, personal protective equipment (PPE) for clinical and nonclinical staff, a preprocedural mouth rinse, and aerosol management have been discussed and implemented in few countries. Three studies recommended that elective treatments for patients with a temperature of >100.4 F or 38 °C should be postponed or performed in an airborne infection isolation room (AIIR) or negative-pressure room. Limiting the number of patients in the waiting area, the removal of shared objects, proper ventilation, and physical distancing were highly recommended. Psychological distress among dental professionals in relation to existing medical conditions and self-efficacy has been discussed. Conclusions: Although the COVID-19 pandemic has had a substantial impact on the dental profession worldwide, our review highlights many practice management approaches to adopt the new norm. More research highlighting evidence-based safety practices and multisectoral collaboration is required to help dental professionals make informed decisions and make the profession safe, both for the patient and dental professionals.
Reliability of the Soleus H-Reflex in Different Sitting Postures
Authors: Al Amer Hamad S. , Sabbahi Mohamed A. , Olson Sharon L.
Published: November 2020

The Soleus (SOL) Hoffmann reflex (H-reflex) is commonly recorded in sitting position. However, the reliability of recording is unknown. We assessed the reliability of SOL H-reflex amplitude measurements across multiple traces and sessions during erect, slumped, and slouched sitting postures using the generalizability theory. Five traces of the SOL H-reflex maximum amplitude (Hmax) were recorded from 10 healthy participants during erect, slumped, and slouched sitting postures in two sessions. A decision study analysis was then conducted to calculate the reliability coefficients of the Hmax for five traces and two sessions and to mathematically calculate the coefficients for seven and ten traces, and one and three sessions in the three sitting postures. For five traces and two sessions, the results showed reliability coefficients between 0.970 and 0.971, 0.980 and 0.979, and equal to 0.943 for erect, slumped, and slouched sitting, respectively. Averaging five traces of the Hmax in a single recording session was sufficient to obtain acceptable reliability in the three sitting postures (reliability range, 0.892–0.988). It was concluded that the SOL Hmax can be recorded during erect, slumped, and slouched sitting postures with adequate reliability.
A Critical Review of the Material Characteristics of Additive Manufactured IN718 for High-Temperature Application
Authors: Yong Ching Kiat , Gibbons Gregory J. , Wong Chow Cher , West Geoff
Published: November 2020

This paper reviews state of the art additive manufactured (AM) IN718 alloy intended for high-temperature applications. AM processes have been around for decades and have gained traction in the past five years due to the huge economic benefit this brings to manufacturers. It is crucial for the scientific community to look into AM IN718 applicability in order to see a step-change in production. Microstructural studies reveal that the grain structure plays a significant role in determining the fatigue lifespan of the material. Controlling IN718 respective phases such as the ϒ’’, δ and Laves phase is seen to be crucial. Literature reviews have shown that the mechanical properties of AM IN718 were very close to its wrought counterpart when treated appropriately. Higher homogenization temperature and longer ageing were recommended to dissolve the damaging phases. Various surface enhancement techniques were examined to find out their compatibility to AM IN718 alloy that is intended for high-temperature application. Laser shock peening (LSP) technology stands out due to the ability to impart low cold work which helps in containing the beneficial compressive residual stress it brings in a high-temperature fatigue environment.
Oxidative Stress in Cytokine-Induced Dysfunction of the Pancreatic Beta Cell: Known Knowns and Known Unknowns
Authors: Kowluru Anjaneyulu
Published: November 2020

Compelling evidence from earlier studies suggests that the pancreatic beta cell is inherently weak in its antioxidant defense mechanisms to face the burden of protecting itself against the increased intracellular oxidative stress following exposure to proinflammatory cytokines. Recent evidence implicates novel roles for nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Noxs) as contributors to the excessive intracellular oxidative stress and damage under metabolic stress conditions. This review highlights the existing evidence on the regulatory roles of at least three forms of Noxs, namely Nox1, Nox2, and Nox4, in the cascade of events leading to islet beta cell dysfunction, specifically under the duress of chronic exposure to cytokines. Potential crosstalk between key signaling pathways (e.g., inducible nitric oxide synthase [iNOS] and Noxs) in the generation and propagation of reactive molecules and metabolites leading to mitochondrial damage and cell apoptosis is discussed. Available data accrued in investigations involving small-molecule inhibitors and antioxidant protein expression methods as tools toward the prevention of cytokine-induced oxidative damage are reviewed. Lastly, current knowledge gaps in this field, and possible avenues for future research are highlighted.
Origin and Nature of Parental Magma and Sulfide Segregation of the Baixintan Magmatic Ni–Cu Sulfide Deposit, Southern Central Asian Orogenic Belt (CAOB), NW China: Insights from Mineral Chemistry of Chromite and Silicate Minerals
Authors: Ruan Banxiao , Liao Mingyang , Sun Bingke , Chen Chao
Published: November 2020

The mineral chemistry of chromite and silicate minerals in the Baixintan magmatic Ni-Cu sulfide deposit in the Northern Tianshan, southern Central Asian Orogenic Belt (CAOB) are reported here. Two types of chromite were identified in mafic-ultramafic rocks. Type I chromite occurs as inclusions encased in olivine and has a primary and magmatic origin and homogeneous composition with Cr# values (49–66). It is characterized by high Ti contents (0.33–1.52 wt%) and small quantities of ZnO (0–0.21 wt%), MnO (0.28–0.45 wt%), and NiO (0.06–0.24 wt%) contents. In contrast, type II chromite with interstitial phase and larger compositional variations has significantly higher TiO2 (up to 6.2 wt%) and FeOt contents (up to 69.3 wt%) and slightly lower Al2O3 (minimum 3.0 wt%) and MgO contents (minimum 0.53 wt%). It is considered to crystallize from a more evolved and fractionated melt and suffers from post-magmatic alteration, such as serpentinization and chloritization. The olivine has forsterite values (Fo) varying from 76.8 to 85.6. The parental magma is characterized by high temperature (1389 °C), high pressure (3.8 Gpa), and high Mg content (11.4 wt%) with oxidized (FMQ + 1.6) and hydrous nature based on compositions of primary chromite and olivine–chromite pairs. The intrusion originated from high-degree partial melting of depleted mantle that had been modified by crustal components and metasomatized by subduction fluid in a post-orogenic extensional setting. Two stages of sulfide segregation have been recognized. Early segregation led to the depletion of platinum group elements (PGE), and disseminated sulfide mineralization was the product of later segregation. The assimilation of crustal Si and S components played more important roles on sulfide segregation rather than fractional crystallization.
Combined Cutaneous Therapy Using Biocompatible Metal-Organic Frameworks
Authors: Taherzade Seyed Dariush , Rojas Sara , Soleimannejad Janet , Horcajada Patricia
Published: November 2020

Combined therapies emerge as an interesting tool to overcome limitations of traditional pharmacological treatments (efficiency, side effects). Among other materials, metal-organic frameworks (MOFs) offer versatilities for the accommodation of multiple and complementary active pharmaceutical ingredients (APIs): accessible large porosity, availability of functionalization sites, and biocompatibility. Here, we propose topical patches based on water-stable and biosafe Fe carboxylate MOFs (MIL-100 and MIL-127), the biopolymer polyvinyl alcohol (PVA) and two co-encapsulated drugs used in skin disorders (azelaic acid (AzA) as antibiotic, and nicotinamide (Nic) as anti-inflammatory), in order to develop an advanced cutaneous combined therapy. Exceptional MOF drug contents were reached (total amount 77.4 and 48.1 wt.% for MIL-100 and MIL-127, respectively), while an almost complete release of both drugs was achieved after 24 h, adapted to cutaneous delivery. The prepared cutaneous PVA-MOF formulations are safe and maintain the high drug-loading capacity (total drug content of 38.8 and 24.2 wt.% for MIL-100 and MIL-127, respectively), while allowing a controlled delivery of their cargoes, permeating through the skin to the active target sites. The total amount of drug retained or diffused through the skin is within the range (Nic), or even better (AzA) than commercial formulations. The presented results make these drug combined formulations promising candidates for new cutaneous devices for skin treatment.
Porous Si/Fe2O3 Dual Network Anode for Lithium–Ion Battery Application
Authors: Chen Yanxu , Yan Yajing , Liu Xiaoli , Zhao Yan , Wu Xiaoyu , Zhou Jun , Wang Zhifeng
Published: November 2020

Benefiting from ultra-high theoretical capacity, silicon (Si) is popular for use in energy storage fields as a Li–ion battery anode material because of its high-performance. However, a serious volume variation happens towards Si anodes in the lithiation/delithiation process, triggering the pulverization of Si and a fast decay in its capacity, which greatly limits its commercial application. In our study, a porous Si/Fe2O3 dual network anode was fabricated using the melt-spinning, ball-milling and dealloying method. The anode material shows good electrochemical performance, delivering a reversible capacity of 697.2 mAh g−1 at 200 mA g−1 after 100 cycles. The high Li storage property is ascribed to the rich mesoporous distribution of the dual network structure, which may adapt the volume variation of the material during the lithiation/delithiation process, shorten the Li–ion diffusion distance and improve the electron transport speed. This study offers a new idea for developing natural ferrosilicon ores into the porous Si-based materials and may prompt the development of natural ores in energy storage fields.
NIR Photoregulated Theranostic System Based on Hexagonal-Phase Upconverting Nanoparticles for Tumor-Targeted Photodynamic Therapy and Fluorescence Imaging
Authors: Zhao Linlin , Choi Jongseon , Lu Yan , Kim So Yeon
Published: November 2020

Although photodynamic therapy (PDT) is an effective, minimally invasive therapeutic modality with advantages in highly localized and specific tumor treatments, large and deep-seated cancers within the body cannot be successfully treated due to low transparency to visible light. To improve the therapeutic efficiency of tumor treatment in deep tissue and reduce the side effects in normal tissue, this study developed a near-infrared (NIR)-triggered upconversion nanoparticle (UCNP)-based photosensitizer (PS) carrier as a new theranostics system. The NaYF4:Yb/Er UCNPs were synthesized by a hydrothermal method, producing nanoparticles of a uniformly small size (≈20 nm) and crystalline morphology of the hexagonal phase. These UCNPs were modified with folic acid-conjugated biocompatible block copolymers through a bidentate dihydrolipoic acid linker. The polymer modified hexagonal phase UCNPs (FA-PEAH-UCNPs) showed an improved dispersibility in the aqueous solution and strong NIR-to-vis upconversion fluorescence. The hydrophobic PS, pheophorbide a (Pha), was then conjugated to the stable vectors. Moreover, these UCNP-based Pha carriers containing tumor targeting folic acid ligands exhibited the significantly enhanced cellular uptake efficiency as well as PDT treatment efficiency. These results suggested that this system could extend the excitation wavelength of PDT to the NIR region and effectively improve therapeutic efficiency of PSs.
The Tension-Twist Coupling Mechanism in Flexible Composites: A Systematic Study Based on Tailored Laminate Structures Using a Novel Test Device
Authors: Beter Julia , Schrittesser Bernd , Meier Gerald , Lechner Bernhard , Mansouri Mohammad , Fuchs Peter Filipp , Pinter Gerald
Published: November 2020

The focus of this research is to quantify the effect of load-coupling mechanisms in anisotropic composites with distinct flexibility. In this context, the study aims to realize a novel testing device to investigate tension-twist coupling effects. This test setup includes a modified gripping system to handle composites with stiff fibers but hyperelastic elastomeric matrices. The verification was done with a special test plan considering a glass textile as reinforcing with different lay-ups to analyze the number of layers and the influence of various fiber orientations onto the load-coupled properties. The results demonstrated that the tension-twist coupling effect strongly depends on both the fiber orientation and the considered reinforcing structure. This enables twisting angles up to 25° with corresponding torque of about 82.3 Nmm, which is even achievable for small lay-ups with 30°/60° oriented composites with distinct asymmetric deformation. For lay-ups with ±45° oriented composites revealing a symmetric deformation lead, as expected, no tension-twist coupling effect was seen. Overall, these findings reveal that the described novel test device provides the basis for an adequate and reliable determination of the load-coupled material properties between stiff fibers and hyperelastic matrices.
Synergistic Action of Montmorillonite with an Intumescent Formulation: The Impact of the Nature and the Strength of Acidic Sites on the Flame-Retardant Properties of Polypropylene Composites
Authors: Martins Raíssa Carvalho , Rezende Michelle Jakeline Cunha , Nascimento Marco Antonio Chaer , Nascimento Regina Sandra Veiga , Ribeiro Simone Pereira da Silva
Published: November 2020

A raw montmorillonite (Mt) was submitted to different acidic activation times in order to investigate the influence of the strength and the nature (Brønsted and Lewis) of acidic sites on the synergistic action with an intumescent formulation (IF) composed of ammonium polyphosphate (APP) and pentaerythritol (PER) when incorporated into a polypropylene (PP) matrix. The acidity of the Mt samples was quantified by ammonia temperature-programmed desorption (TPD-NH3) and Fourier transform infrared spectroscopy (FTIR) with pyridine adsorption. The mineral clays were also characterized by X-ray fluorescence (XRF), X-ray diffraction (XRD), nitrogen adsorption analysis and particle size distribution. Thermogravimetric analysis (TGA), limit oxygen index (LOI) and UL-94 were performed to evaluate the flame-retardant properties and the thermal stability. The TGA results show that the final residue increased 2 to 3 fold in comparison to the values predicted theoretically. The flammability properties achieved a maximum for the system containing an excess of moderate-strength Brønsted sites relative to the Lewis ones, reaching 38% in the LOI test. This result suggests that the presence of these Brønsted acidic sites is important, as they take part in the esterification reaction between APP and PER which gives rise to the char formation. The FTIR-Pyr adsorption and flammability results indicate that both the nature and strength of the acidic sites influence the flame-retardant properties.
Wide Field Spectral Imaging with Shifted Excitation Raman Difference Spectroscopy Using the Nod and Shuffle Technique
Authors: Korinth Florian , Schmälzlin Elmar , Stiebing Clara , Urrutia Tanya , Micheva Genoveva , Sandin Christer , Müller André , Maiwald Martin , Sumpf Bernd , Krafft Christoph , Tränkle Günther , Roth Martin M. , Popp Jürgen
Published: November 2020

Wide field Raman imaging using the integral field spectroscopy approach was used as a fast, one shot imaging method for the simultaneous collection of all spectra composing a Raman image. For the suppression of autofluorescence and background signals such as room light, shifted excitation Raman difference spectroscopy (SERDS) was applied to remove background artifacts in Raman spectra. To reduce acquisition times in wide field SERDS imaging, we adapted the nod and shuffle technique from astrophysics and implemented it into a wide field SERDS imaging setup. In our adapted version, the nod corresponds to the change in excitation wavelength, whereas the shuffle corresponds to the shifting of charges up and down on a Charge-Coupled Device (CCD) chip synchronous to the change in excitation wavelength. We coupled this improved wide field SERDS imaging setup to diode lasers with 784.4/785.5 and 457.7/458.9 nm excitation and applied it to samples such as paracetamol and aspirin tablets, polystyrene and polymethyl methacrylate beads, as well as pork meat using multiple accumulations with acquisition times in the range of 50 to 200 ms. The results tackle two main challenges of SERDS imaging: gradual photobleaching changes the autofluorescence background, and multiple readouts of CCD detector prolong the acquisition time.