bluuebunny/crossref_metadata_2025 huggingface dataset:
MANAJEMEN PENGELOLAAN AGROSISTEM DATARAN TINGGI DI DESA BISSOLORO KECAMATAN BUNGAYA KABUPATEN GOWA
Authors: Hamsiah  , Ansyar  , Jumriani Dambe
Published: June 2023

Penelitian ini bertujuan untuk mengetahui dan menganilisi sistem pertanian, jenis-jenis tanaman yang dibudidayakan serta manajemen pengelolaan lahan yang dilakukan petani di desa Bissoloro. Desa Bissoloro Kecamatan Bungaya Kabupaten Gowa. Penelititan ini ini dilaksanakan selama 3 bulan dimulai pada April hingga Juni 2022. Metode yang digunakan pada penelitian ini adalah metode kualitatif dalam bentuk studi kasus. Data yang diperoleh dalam penelitian ini dalam bentuk data primer dan data sekunder. Data primer diperoleh dari FGD (Focus Group Discussion), kuesioner, observasi, dan wawancara. Data sekunder diperoleh dan diolah berdasarkan statistik dari kantor desa. Teknik penentuan responden pada penelitian ini menggunakan teknik pengambilan contoh secara sengaja (purposive sampling), maka melalui metode tersebut penulis secara langsung memilih sendiri pihak-pihak yang menjadi responden. Pihak responden pada penelitian ini adalah petani yang ada di Desa Bissoloro. Berdasarkan penelitian yang telah dilakukan di Desa Bissoloro Kecamatan Bungaya Kabupaten Gowa dapat disimpulkan bahwa masih terdapat beberapa kekurangan dalam pengolahan lahan yaitu penggunaan bahan kimia yang masih tinggi, pengolahan tata guna lahan pada tingkat 45 derajat yang masih kurang efektif,pola tanam masyarakat yang tidak serentak, kurangnya penampungan air.
Public attitudes to urban foxes in London and the south east.
Authors: Brand Adele , Baldwin Marc
Published: June 2023

Humans and foxes have a long history of coexistence and conflict. We assessed the “likeable” and “reproachable” characters of foxes as perceived by two populations of adults and children in England via a questionnaire. Londoners were more averse to neighbourhood foxes than respondents from the south-east, while attitudes of women were more favourable than those of men. Our data add to the pool of information about human perception of urban wildlife and may contribute to the development of conflict-resolution strategies by helping target education.
Food caching as observed through use of den boxes by European pine martens (Martes martes)
Authors: Twining Joshua , Birks Johnny , Martin John , Tosh David
Published: June 2023

Artificial den boxes have been used to supplement denning sites of the European pine marten (Martes martes) in Scotland and Northern Ireland where natural arboreal cavities are scarce. Here, information on food caches from annual checks are reported. Pine martens predominantly cached birds, largely juvenile passerines, followed by small mammals and amphibians. This investigation highlights the potential importance of food caching in the species, as well as the ability of artificial den box schemes to explore enigmatic aspects of marten ecology in the future.
An improved identification marking method for hedgehogs.
Authors: Reeve Nigel , Bowen Clare , Gurnell John
Published: June 2023

As part of a long-term study of hedgehogs in The Regent’s Park (London, U.K.) begun in May 2014, we developed and tested an improved identification marking method using 10 mm lengths of yellow plastic sleeving (heatshrink polyolefin) bearing pre-printed animal identification numbers. During twice-yearly study periods, six spines on each hedgehog were marked with duplicate numbers in a single central patch just behind the crown of the head; easily visible in both active and rolled-up hedgehogs. From May 2016 (animals marked in September 2015) to May 2018, the mean number of tags remaining in the pelage after eight months (September to May) was 3.78 (SE = 0.24, n = 45) and 4.16 (SE = 0.31, n = 25) after four months (May to September). In five additional cases, individuals were easily identified after periods of one year or more. The tags have minimal welfare implications, do not interfere with the function of the spines and can be easily read by anyone finding the animal. We conclude that this method is very effective, requires minimal handling and is suitable for use by volunteer field workers. Only one marked spine allows correct identification, making it especially suitable for identifying road-killed, partially eaten or decomposed hedgehogs.
Pengaruh Pemberdayaan Perempuan Terhadap Ketahanan Perekonomian Keluarga
Authors: Novitasari Avinda
Published: June 2023

Jenis kelamin masih menjadi salah satu isu hangat khususnya pada negara berkembang. Sebagian besar negara berkembang masih memegang kuat tradisi dalam pembagian peran antara laki-laki dan perempuan. Oleh karena itu, pemberdayaan perempuan perlu mendapatkan perhatian supaya gender harmony dapat tercapai. Gender harmony akan memberi dampak signifikan dalam keluarga maupun dalam masyarakat. Penulisan penelitian ini menghasilkan beberapa pokok bahasan yaitu : (1) Keberadaan Kelompok Usaha Bersama (KUB) mampu meningkatkan sumberdaya ekonomi keluarga. (2) Tingkat Partisipasi Angkatan Kerja wanita mengalami peningkatan dari tahun ke tahun. Pemberdayaan perempuan meningkatkan kecenderungan masyarakat untuk meningkatkan taraf kehidupan. (4) Telah terjadi pergeseran pola relasi dalam keluarga sesuai dengan perubahan kondisi sosial budaya masyarakat. (5) Pemberdayaan perempuan sangat mempengaruhi ketahanan perekonomian keluarga. Data dalam penelitian ini diperoleh dari literatur atau kepustakaan (library research). Sehingga berdasarkan tingkat eksplanasinya penelitian ini merupakan bersifat deskriptif. Penelitian adalah penelitian kualitatif, karena hasil penelitian dinyatakan dalam bentuk verbal dan kemudian dianalisis. Penelitian ini mengenai pengaruh pemberdayaan perempuan terhadap ketahanan perekonomian
Perubahan Sosial Masyarakat Pasca Pengalihfungsian Lahan Sawah menjadi Lahan Perikanan
Authors: Hidayah Juwita , Malik Abdul
Published: June 2023

Penelitian ini bertujuan untuk mendeskripsikan perubahan sosial masyarakat desa Talun, dinamika proses belajar masyarakat selama proses alih fungsi lahan serta dampak yang ditimbulkannya. Penelitian ini menggunakan pendekatan kualitatif dengan subjek penelitian meliputi ketua POKDAKAN Mina Sejahtera, ketua bidang kuliner, ketua bidang jasa pemancingan, sekretaris desa, serta tokoh masyarakat. Teknik keabsahan data menggunakan triangulasi data, sementara teknik analisis data meliputi pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan perubahan sosial yang terjadi pada masyarakat desa Talun dipengaruhi oleh faktor internal dan faktor eksternal. Perubahan sosial masyarakat desa Talun termasuk dalam perubahan imanen serta perubahan terjadi pada level mikro, intermediate, makro. Perubahan sosial masyarakat desa Talun dimensi struktural; dimensi kultural; dan dimensi interaksional. Proses belajar yang berlangsung pada masyarakat desa talun melalui praktek langsung (bekerja sambil belajar), diskusi kelompok serta penyuluhan. Dampak positif yang ditimbulkan antara lain: perubahan status sosial masyarakat; tetap dilestarikannya nilai-nilai budaya seperti sambatan,  manganan, sedekah bumi dan sedekah tambak; pendapatan masyarakat bertambah; bertambahnya keikut sertaan masyarakat pada politik desa; masyarakat desa Talun mengalami kemajuan dalam berpikir. Sedangkan dampak negatif yang ditimbulkan yaitu penyimpangan sosial berupa minuman beralkohol yang dibawa masuk oleh para pengunjung.
Evaluasi Program Pelatihan Fungsional Dasar bagi Penyuluh Keluarga Berencana di BKKBN Provinsi Jawa Barat
Authors: Ikhsania Putri Zahra , Sukmana Cucu
Published: June 2023

Penelitian ini bertujuan untuk mendeskripsikan hasil evaluasi program pelatihan melalui model evaluasi CIPP (Context, Input, Process, Product) pada program pelatihan Fungsional Dasar bagi Penyuluh Keluarga Berencana di BKKBN Provinsi Jawa Barat. Penelitian ini menggunakan pendekatan mixed method yaitu menyatukan dua metode antara metode kualitatif dengan metode kuantitatif. Teknik pengumpulan data yang digunakan adalah wawancara, observasi, dokumentasi dan kuesioner yang dihitung melalui pengukuran skala likert. Untuk mendapatkan data yang kredibel peneliti menggunakan triangulasi metode dan triangulasi sumber. Hasil dari penelitian menunjukkan bahwa dilihat dari evaluasi wawancara, observasi dan dokumentasi diperoleh kategori nilai baik. Sedangkan untuk hasil kuesioner peserta diperoleh hasil sangat baik dengan persentase 88,16%. Hasil evaluasi aspek context, setelah di akumulasikan dari segi latar belakang dan ketersediaan dokumen dikategorikan baik. Hasil evaluasi aspek input, setelah di akumulasikan dilihat dari segi widyaiswara program, kurikulum program, sarana dan prasarana, peserta pelatihan, serta pendanaan program maka secara umum dapat dikategorikan cukup baik. Hasil evaluasi aspek process setelah di akumulasikan menunjukkan bahwa dilihat dari segi persiapan program, pengelolaan program, evaluasi program, dan kesesuaian perencanaan dengan hasil pelaksanaan maka secara umum termasuk ke dalam kategori baik. Hasil evaluasi aspek product setelah di akumulasikan menunjukkan bahwa dari segi hasil pembelajaran dan tanggapan terhadap pelaksanaan program maka secara umum termasuk ke dalam kategori baik.
Thermography of single line scans performed on the commercial powder bed fusion machine for the Additive Manufacturing Benchmark Test Series (AM-Bench 2018)
Authors: Heigel Jared C
Published: June 2023

This document provides details on the files available in the dataset "In situ thermographic measurements of single line scans performed for the Additive Manufacturing Benchmark Test Series (AM-Bench 2018)." These measurements are performed as part of the Additive Manufacturing Benchmark Test Series (AMBench) supporting the melt pool geometry (length) and cooling rate challenges (CHAL-AMB2018-02-MP-Length and CHAL-AMB2018-02-CR). The following sections provided details on the experiments and data files.
What is the most giant sauropod from Argentina? Diversity of large titanosaurs from Patagonia
Authors: Calvo Jorge Orlando
Published: June 2023

This work’s intent is to establish which was the most giant titanosaurid sauropod from Argentina. The evidence is scarce; however, we have tried to select the largest bones of the nine most giant titanosaurids. Argentinosaurus has been proposed as the largest titanosaurid, but recently a new king has been erected: the Patagotitan. In this review, we will see that there are some inconsistences and difficulties to define which is the largest. In other words, giant titanosaurids were a group of sauropods with a variable morphology and probably the overall shape was different. Among the largest titanosaurids, we have included Argyrosaurus superbus, Antarctosaurus giganteus, Argentinosaurus huinculensis, Puertasaurus reuili, Futalognkosaurus dukei, Traukutitan eocaudata, Dreadnoughtus schrani, Notocolossus gonzalezparejasi, and Patagotitan mayorum.
HAZIR GİYİM SEKTÖRÜNDE INFLUENCERLARIN MARKA İMAJI VE SATIN ALMA NİYETİ ÜZERİNDEKİ ETKİSİ: Z KUŞAĞI ÖRNEĞİ
Authors: Onurlubaş Ebru
Published: June 2023

Bu araştırmanın amacı, hazır giyim sektöründe yer alan influencerlarının güvenilirlik, uzmanlık ve çekicilik özelliklerinin, Z kuşağındaki tüketicilerin marka imajı ve satın alma niyeti üzerindeki etkilerini belirlemektir. Edirne'de yaşayan Z kuşağına ait 420 tüketici ile yapılan araştırmada kaynak güvenilirliği modelinin alt boyutlarından olan influencerların çekicilik, uzmanlık ve güvenirlik özelliklerinin marka imajı ve satın alma niyetiyle arasında düşük ve orta derecede ilişkiler olduğu ortaya koyulmuştur. Influencerların sahip olduğu özelliklerin satın alma niyeti üzerindeki etkisinde kaynak güvenirliği boyutlarından güvenirliğin orta düzeyde çekicilik ve uzmanlığın düşük düzeyde pozitif anlamlı bir etkisinin olduğu görülmektedir. Influencerların marka imajı üzerindeki etkisinde ise kaynak güvenirliği boyutlarından çekiciliğin orta düzeyde, güvenirlik ve uzmanlığın düşük düzeyde pozitif anlamlı bir etkisinin olduğu görülmektedir.
INTEGRATING LIGHT ELEMENTS IN FASHION: PRACTICE-BASED DESIGN APPROACH
Authors: Yazgan Bulgun Ender , Vuruşkan Arzu , Tekcan Elif
Published: June 2023

In history, the relationship between fashion and technology has influenced the ever-changing silhouettes of the body, the quality of materials used to construct these silhouettes, and the colors giving liveliness to the material. Today, influenced by the digital revolution and innovation in advanced materials, the fashion industry benefits from the increasing possibilities of technology to develop alternative functions even to the most conventional dress forms, such as wedding gowns. This integration, which necessitates the contribution of different know-how and expertise, also provides a creative platform for developing interdisciplinary, practice-based design research and applications. In this study, an innovative wedding dress using light as a design element was produced with the joint contribution of designers and engineers based in Izmir, considered the capital of bridalwear in Turkey. This project, which considers light as a new design element that increases the expressive power of the dress, aims to offer an alternative to both the wedding dress category and the existing examples incorporating light technologies. In accordance with the main framework, research questions, and project design concept, the study conducts a literature review examining current design examples using different light technologies (LED, optical fibers, etc.). Following this, the stages of design, sample development and production processes are presented with relevant visuals. It is believed that this study, whose research, design development, and production processes are shared in detail, will set an example for future interdisciplinary projects.
Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice
Authors: Thome Christian , Janssen Jan Maximilian , Karabulut Seda , Acuna Claudio , D’Este Elisa , Soyka Stella J. , Baum Konrad , Bock Michael , Lehmann Nadja , Hasegawa Masashi , Ganea Dan Alin , Benoit Chloé Maëlle , Gründemann Jan , Schultz Christian , Bennett Vann , Jenkins Paul M. , Engelhardt Maren
Published: June 2023

The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation of output generation. Recent studies shedding light on AIS function used predominantly
post hoc
approaches since no robust murine
in vivo
live reporters exist. Here, we introduce a reporter line in which the AIS is intrinsically labeled by an ankyrin-G-GFP fusion protein activated by Cre recombinase, tagging the native
Ank3
gene. Using confocal, superresolution, and two-photon microscopy as well as whole-cell patch-clamp recordings
in vitro, ex vivo
, and
in vivo
, we confirm that the subcellular scaffold of the AIS and electrophysiological parameters of labelled cells remain unchanged. We further uncover rapid AIS remodeling following increased network activity in this model system, as well as highly reproducible
in vivo
labeling of AIS over weeks. This novel reporter line allows longitudinal studies of AIS modulation and plasticity
in vivo
in real time and thus provides a unique approach to study subcellular plasticity in a broad range of applications.
SIRT-1 is required for release of enveloped picornaviruses
Authors: Jassey Alagie , Logue James , Weston Stuart , Wagner Michael A. , Galitska Ganna , Miller Katelyn , Frieman Matthew B. , Jackson William T.
Published: June 2023

Enterovirus D68 is a re-emerging enterovirus that causes acute respiratory illness in infants and has recently been linked to Acute Flaccid Myelitis. Here, we show that the histone deacetylase, SIRT-1, is essential for autophagy and EV-D68 infection. Knockdown of SIRT-1 blocks autophagy and reduces EV-D68 extracellular titers. The proviral activity of SIRT-1 does not require its deacetylase activity or functional autophagy. SIRT-1’s proviral activity is, we demonstrate, mediated through the repression of ER stress. Inducing ER stress through thapsigargin treatment or SERCA2A knockdown in SIRT-1 knockdown cells had no additional effect on EV-D68 extracellular titers. Knockdown of SIRT-1 also decreases poliovirus and SARS-CoV-2 titers but not coxsackievirus B3. In non-lytic conditions, EV-D68 is primarily released in an enveloped form, and SIRT-1 is required for this process. Our data show that SIRT-1, through its translocation to the cytosol, is critical to promote the release of enveloped EV-D68 viral particles.
Network-Level Changes in the Brain Underlie Fear Memory Strength
Authors: Haubrich Josue , Nader Karim
Published: June 2023

The strength of a fear memory significantly influences whether it drives adaptive or maladaptive behavior in the future. Yet, how mild and strong fear memories differ in underlying biology is not well understood. We hypothesized that this distinction may not be exclusively the result of changes within specific brain regions, but rather the outcome of collective changes in connectivity across multiple regions within the neural network. To test this, rats were fear conditioned in protocols of varying intensities to generate mild or strong memories. Neuronal activation driven by recall was measured using cfos immunohistochemistry in 12 brain regions implicated in fear learning and memory. The interregional coordinated brain activity was computed and graph-based functional networks were generated to compare how mild and strong fear memories differ at the systems level. Our results show that mild fear recall is supported by a well-connected brain network with small-world properties in which the amygdala is well-positioned to be modulated by other regions. In contrast, this connectivity is disrupted in strong fear memories and the amygdala is isolated from other regions. These findings indicate that the neural systems underlying mild and strong fear memories differ, with implications for understanding and treating disorders of fear dysregulation.
Sensory neurons couple arousal and foraging decisions in C. elegans
Authors: Scheer Elias , Bargmann Cornelia I.
Published: June 2023

Foraging animals optimize feeding decisions by adjusting both common and rare behavioral patterns. Here, we characterize the relationship between an animal’s arousal state and a rare decision to leave a patch of bacterial food. Using long-term tracking and behavioral state classification, we find that food leaving decisions in
C. elegans
are coupled to arousal states across multiple timescales. Leaving emerges probabilistically over minutes from the high arousal roaming state, but is suppressed during the low arousal dwelling state. Immediately before leaving, animals have a brief acceleration in speed that appears as a characteristic signature of this behavioral motif. Neuromodulatory mutants and optogenetic manipulations that increase roaming have a coupled increase in leaving rates, and similarly acute manipulations that inhibit feeding induce both roaming and leaving. By contrast, inactivating a set of chemosensory neurons that depend on the cGMP-gated transduction channel TAX-4 uncouples roaming and leaving dynamics. In addition,
tax-4-
expressing sensory neurons promote lawn-leaving behaviors that are elicited by feeding inhibition. Our results indicate that sensory neurons responsive to both internal and external cues play an integrative role in arousal and foraging decisions.
Unraveling the mechanisms behind joint damage
Authors: Fu Wenyu , Liu Chuan-ju
Published: June 2023

A subtype of myeloid monocyte mediates the transition from autoimmunity to joint destruction in rheumatoid arthritis.
Fleeing Iraq with nothing but a dream
Authors: Abood Arby
Published: June 2023

Facing the harsh realities of life as a refugee in Jordan and the United States, an ambitious young man holds to a conviction: that he will, one day, get a PhD.
A deep learning-based approach for emotional analysis of sports dance
Authors: Sun Qunqun , Wu Xiangjun
Published: June 2023

There is a phenomenon of attaching importance to technique and neglecting emotion in the training of sports dance (SP), which leads to the lack of integration between movement and emotion and seriously affects the training effect. Therefore, this article uses the Kinect 3D sensor to collect the video information of SP performers and obtains the pose estimation of SP performers by extracting the key feature points. The Arousal-Valence (AV) emotion model, based on the Fusion Neural Network model (FUSNN), is also combined with theoretical knowledge. It replaces long short term memory (LSTM) with gate recurrent unit (GRU), adds layer-normalization and layer-dropout, and reduces stack levels, and it is used to categorize SP performers’ emotions. The experimental results show that the model proposed in this article can accurately detect the key points in the performance of SP performers’ technical movements and has a high emotional recognition accuracy in the tasks of 4 categories and eight categories, reaching 72.3% and 47.8%, respectively. This study accurately detected the key points of SP performers in the presentation of technical movements and made a major contribution to the emotional recognition and relief of this group in the training process.
Analysis of the HD-Zip I transcription factor family in Salvia miltiorrhiza and functional research of SmHD-Zip12 in tanshinone synthesis
Authors: Bai Yanhong , Zhou Ying , Lei Qiaoqi , Wang Yu , Pu Gaobin , Liu Zhenhua , Chen Xue , Liu Qian
Published: June 2023

Background

The homeodomain-leucine zipper I (HD-Zip I) transcription factor is a plant-specific protein that plays an essential role in the abiotic stress response of plants. Research on the HD-Zip I family in Salvia miltiorrhiza is still lacking.

Methods and Results

In this study, a total of 25 SmHD-Zip I proteins were identified. Their characterizations, phylogenetic relationships, conserved motifs, gene structures, and cis-elements were analyzed comprehensively using bioinformatics methods. Expression profiling revealed that SmHD-Zip I genes exhibited distinctive tissue-specific patterns and divergent responses to ABA, PEG, and NaCl stresses. SmHD-Zip12 responded the most strongly to ABA, PEG, and NaCl, so it was used for transgenic experiments. The overexpression of SmHD-Zip12 significantly increased the content of cryptotanshinone, dihydrotanshinone I, tanshinone I, and tanshinone IIA by 2.89-fold, 1.85-fold, 2.14-fold, and 8.91-fold compared to the wild type, respectively. Moreover, in the tanshinone biosynthetic pathways, the overexpression of SmHD-Zip12 up-regulated the expression levels of SmAACT, SmDXS, SmIDS, SmGGPPS, SmCPS1, SmCPS2, SmCYP76AH1, SmCYP76AH3, and SmCYP76AK1 compared with the wild type.

Conclusions

This study provides information the possible functions of the HD-Zip I family and lays a theoretical foundation for clarifying the functional mechanism of the SmHD-Zip12 gene in regulating the synthesis of tanshinone in S. miltiorrhiza.
MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo
Authors: Li Yaqin , Wei Yimiao , Zhang Honglei , Bai Ying , Wang Xiuting , Li Qi , Liu Yatao , Wang Shuling , Wang Jiapu , Wen Songquan , Li Jiarong , Zhao Weihong
Published: June 2023

Background

MicroRNA-154-5p (miR-154-5p) plays a role in tumorigenesis in diverse human malignancies. Nevertheless, little is known about the mechanism by which miR-154-5p alters the growth and metastasis of cervical cancer. This research aimed to analyze the role of miR-154-5p in the pathology of cervical cancer in vitro and in vivo.

Methods

The level of miR-154-5p in human papillomavirus 16 positive cervical cancer cells was examined by real-time quantitative polymerase chain reaction. Bioinformatics predicted the downstream targets and potential functions of miR-154-5p. Furthermore, lentiviral technology was used to construct SiHa cell lines with stable up- and down-expression levels of miR-154-5p. Its differential expression effects on the progress and metastasis of cervical cancer were analyzed using cell culture and animal models.

Results

MiR-154-5p showed low expression in cervical cancer cells. Overexpression of miR-154-5p could markedly inhibit the proliferation, migration, and colony formation ability of SiHa cells, concomitantly leading to G1 arrest of the cell cycle, while silencing miR-154-5p triggered the opposite results. Meanwhile, overexpression of miR-154-5p restrained the growth and metastasis of cervical cancer by silencing CUL2 in vivo. Additionally, miR-154-5p reduced CUL2 level, and overexpression of CUL2 influenced the effect of miR-154-5p in cervical cancer. In conclusion, miR-154-5p restrained the growth and metastasis of cervical cancer by directly silencing CUL2.
IMPACTOS DA CRISE CAUSADA PELO COVID-19 NA GESTÃO FINANCEIRA DAS EMPRESAS RURAIS DO MUNICÍPIO DE MANAUS
Authors: Guimarães Dandra Taiany de Almeida , Moura Maria Luíza Batista , Matos Nyalle Barboza , Carneiro Leandro Marcondes , Oliveira Elisangela Leitão , Dias André Petzhold
Published: June 2023

A presente pesquisa busca analisar os desafios enfrentados pelas empresas rurais em razão dos efeitos da pandemia de Covid-19 sobre seus empreendimentos e os impactos causados em seus faturamentos no município de Manaus. Como procedimento para realização da pesquisa adotou-se a pesquisa de campo para coleta de dados direcionada aos produtores rurais, com aplicação de questionário efetuada em quatro feiras distintas da cidade e, no período de um mês, foi entrevistado um total de 70 (setenta) produtores. A partir da pandemia e da crise financeira instaurada, os agricultores utilizaram várias estratégias de comercialização para combater à crise, sendo que, as alternativas mais aplicadas foram corte de gastos, vendas pela internet e reunião dos agricultores para facilitar as vendas. Ademais, entre as dificuldades mais apontadas pelos agricultores, está a pouca movimentação de clientes nas feiras, devido o decreto municipal ter restringido a circulação de pessoas e os horários de comercialização; e a redução de produção, devido à escassez de insumos necessários para cultivar os produtos. Foi constatado também que essas complicações causaram redução no faturamento dos feirantes, contudo não extinguiu o negócio.
Development of automotive packaging by applying the QFD method
Authors: Rubert Clauber Koenigkam , De Carvalho Cleginaldo Pereira , De Almeida Maria da Glória Diniz , De Barros José Glenio Medeiros , Sampaio Nilo Antonio de Souza
Published: June 2023

The main operational functions of packaging are: containment, protection/conservation, promotion of the product and/or linking a message, i.e. packaging is almost a part of product marketing. In the automotive industry, the packaging developed serves as a means of packaging and transport ensuring the integrity of the product within the supply chain, at the best cost and within the established deadlines. This paper discusses how Quality Function Deployment (QFD) proves to be an effective methodology for ensuring success in automotive packaging development. The study is delimited to the development of packaging at a vehicle manufacturer in the southern region of the state of Rio de Janeiro. It is expected that the House of Quality, the first stage of the QFD method, presented in this article and used by the packaging development sector, can attract more teams and organizations to adopt QFD in the development of packaging, identifying, and meeting the needs of the company's internal customers and guiding external suppliers in the development of this packaging, aiming for better quality and lower cost packaging.
Geração millennials e economia compartilhada: um novo olhar sobre o significado simbólico do consumo
Authors: Dantas Sérgio Silva , Francischini Andresa Silva Neto , Prado Karen Perrotta Lopes de Almeida , Rodrigues Miriam
Published: June 2023

Cada vez mais, busca-se o entendimento do simbolismo dos produtos, dos hábitos e escolhas do consumidor  e da compreensão do papel do consumo. Nesse contexto, o objetivo deste artigo é entender como se dá o simbolismo do consumo de jovens da geração millennials a partir do advento da economia compartilhada. Já os objetivos específicos são: i) Compreender o modo como os jovens da geração millennials entendem o consumo simbólico; ii) Analisar como se dá a aceitação da economia compartilhada por parte dos jovens da geração millennials; e iii)  Verificar novas formas de expressão de um status social por parte dos jovens da geração millennials, no contexto do compartilhamento de produtos, em contraposição à posse dos mesmos. As análises obtidas mostram que os jovens se apropriam dos produtos como parte da construção das identidades pessoais traduzindo-se muitas vezes pela ostentação que hoje é  realizada por meio das redes sociais. Quanto à adesão à economia compartilhada, percebeu-se que os jovens especialmente os de maior renda, são favoráveis a esse modelo de negócios, apesar de possuírem restrições, especialmente relacionadas a produtos considerados de uso mais pessoal.
The Ameliorative Effect of Ashwagandha- Withania somnifera (L.) Dunal on park25 Induced Neurodegeneration in Drosophila melanogaster Parkinson’s Disease Model
Authors: Murthy Mamatha Nagamadhu , Chandana V. , Nisarga H. D. , Shyamala Baragur Venkatanarayanasetty
Published: June 2023

Ashwagandha - Withania somnifera (L.) Dunal is a perennial shrub belonging to the family Solanaceae. Ashwagandha has been used for over 3000 years in traditional Indian Ayurveda for treatment of various neurological, and stress disorders. The root of Ashwagandha (ASH) is regarded as a tonic, aphrodisiac, narcotic, diuretic, anthelmintic, astringent, thermogenic and stimulant. Ashwagandha with other herbal decoctions was recognized to treat Kampavatha (Parkinson’s Disease) since 18th century. With this wide array of ethnopharmacological relevance, Ashwagandha has been recognized as one of the prominent complementary and alternative medicine to treat many neurodegenerative diseases like Alzheimer’s (AD) and Parkinson’s disease (PD). There is a prominent increase in the cases of AD and PD all over the world and it demands the requirement of complementary and alternative herbal remedies with no/minimal side effects. Many genetic factors are responsible for the onset and progression of PD. Loss-of-function mutations in the parkin gene are a major cause of early onset of autosomal recessive juvenile parkinsonism (AR-JP). Drosophila park25 loss of function mutants exhibit significantly increased number of mitochondria-endoplasmic reticulum contacts and a significantly decreased number of dopaminergic neurons in the adult brain which is the main cause of PD condition. Several studies have demonstrated the ability of Ashwagandha in imparting neuroprotection, improved locomotory ability, memory and learning abilities. The challenge lies in scrutinizing the mechanism and the pathways involved in the neuroprotective properties of this well-known herb. Here in our study, we test the possible neuroprotective effect of Ashwagandha on park25 mutants of Drosophila using lifespan analysis and climbing disability as a disease marker. Parkinson’s mimicking flies were administered with aqueous extraction of Ashwagandha-root mixed with the fly food and subjected to negative geotaxis assay. We observed that there is a prominent increase in the climbing ability in park25 treated flies compared to its age-matched untreated flies. This is the first report showing that, aqueous extraction of Ashwagandha-root extract was able to ameliorate the disease phenotype in the park25 Drosophila Parkinson’s disease model.
Rheumatic Fever and Infective Endocarditis: A Review
Authors: Costa Rysia Ellen Murça Andrade Sales da , Nicoletti Sabrina de Araújo , Amaral Kessily Soares de Jesus do , Matola Maria Fernanda de Souza Borges , Alves Sarah Pereira , Vellano Patricia Oliveira , Damasceno Iangla Araújo de Melo , Herrera Sávia Denise Silva Carlotto , Mendes Seyna Ueno Rabelo , Paiva Maykon Jhuly Martins de
Published: June 2023

Aims: Gather relevant literature, understand and expose the mechanism by which Rheumatic Fever can trigger Endocarditis Method: This is a narrative review, where the following descriptors were used as a source of research: Endocarditis; Rheumatic Fever; Bacterial Endocarditis; in the Scielo, PubMed, LILACS, BVS and MEDLINE databases.

Methodology: This is a narrative review, where the following descriptors were used as a source of research: Endocarditis; Rheumatic Fever; Bacterial Endocarditis; in the Scielo, PubMed, LILACS, BVS and MEDLINE databases.

Results: It is observed that rheumatic fever mainly affects children and adolescents. The immune response triggered by the streptococcal infection results in the production of antibodies that can cross-react with tissues of the body itself, leading to inflammation and damage. This cross-reactivity is an important characteristic of rheumatic fever. Endocarditis is one of the main complications of rheumatic fever and can affect the mural endocardium and frequently the heart valves. The pathophysiology of both diseases and the existing epidemiological data show that the alteration of blood flow near the heart valves damaged by rheumatic fever results in an endocardial lesion and migration of bacteria present in the circulation.

Conclusion: Patients affected by rheumatic fever, present a close relationship with the development of infective endocarditis. From the literature review, it is clear how both conditions are related and require attention because of their complications.
Injúria microbiana e a qualidade microbiológica dos alimentos
Authors: Sola Marília Cristina , Rezende Cíntia Silva Minafra e
Published: June 2023

Introdução: a contaminação microbiológica dos alimentos se apresenta como um grande problema para a indústria, agências reguladoras e consumidores. Os métodos de conservação utilizados como garantia da inocuidade dos alimentos bem como de extensão da vida de prateleira garantem uma redução significativa do número de células viáveis e/esporos. Entretanto, em virtude da aplicação de técnicas como calor, frio, redução da atividade de água e adição de conservantes, parte da população microbiana pode apresentar células com danos letais bem como danos reversíveis, tornando-se injuriadas. Objetivo: realizar uma revisão bibliográfica acerca da ocorrência de injúrias microbianas decorrentes da aplicação de métodos de conservação em alimentos. Metodologia: consulta das bases de dados Pubmed e Scielo, com seleção de artigos publicados entre os anos de 2000 e 2019.  Revisão de literatura: os microrganismos se tornam injuriados após sobreviverem a condições estressantes e perderem parte de suas características funcionais, o que justifica um maior período para multiplicação nos alimentos, assim como em meios de cultura tradicionais. Cabe ressaltar que, caso estes microrganismos sejam expostos à ambientes favoráveis, é possível a recuperação dos danos sofridos. Uma vez regenerados, estes agentes representam um perigo potencial, visto a capacidade de se multiplicarem novamente no alimento, oferecendo riscos aos consumidores e acelerando a deterioração de produtos alimentícios. Conclusão: diante da ocorrência de injúrias microbianas, percebe-se a necessidade de incorporação de procedimentos adequados para recuperação de danos celulares aos métodos oficiais empregados para detecção e enumeração de microrganismos, a fim de garantir a qualidade e inocuidade de alimentos.
Ação da própolis no manejo de lesões não infecciosas em cavidade oral
Authors: Julião Erielma Lomba Dias , Azevedo Juliana Santos de Jesus , Caldas Lucas Henrique Teófilo de Azevedo , Ricarte Rebeka Gadelha , Reis Júlia Vianna Néri Andrade , Dantas Juliana Borges de Lima
Published: June 2023

Introdução: a própolis é um produto natural que apresenta inúmeras propriedades terapêuticas, dentre elas a ação cicatrizante e anti-inflamatória. Diversos estudos têm sugerido o seu emprego no manejo da mucosite oral (MO) e de lesões ulceradas em mucosa bucal. A MO é uma inflamação da mucosa oral, resultante do tratamento quimio e/ou radioterápico. Já as lesões ulceradas aracterizam-se como um distúrbio ulcerativo inflamatório doloroso. Objetivo: discutir a ação da própolis sobre a prevenção e cicatrização de lesões de origem não infecciosa que acometem a cavidade oral. Metodologia: trata-se de uma revisão integrativa da literatura em que foram utilizadas as bases de dados LILACS, PubMed, SciELO e Cochrane, por meio do cruzamento dos descritores em português: “própolis”, “úlceras orais” e “mucosite oral”; e em inglês: “propolis”, “oral ulcer” e “mucositis”. Os seguintes critérios de inclusão foram estabelecidos: ensaios clínicos e revisões sistemáticas, na íntegra, escritos em inglês ou português, entre 2005 e 2018, que utilizaram a própolis de forma tópica ou sistêmica. Resultados: foram incluídos um total de 10 estudos, onde 2 abordaram o uso da própolis em úlceras orais e 8 tiveram como foco a aplicação deste agente no manejo da MO. Quanto ao desfecho, a aplicação da própolis na mucosite se mostrou eficaz em 7 dos 8 estudos. Já se tratando de úlceras orais, a administração deste agente foi efetiva nos 2 estudos. Conclusão: os estudos analisados demostraram que a própolis apresenta propriedades capazes de favorecer a prevenção e cicatrização de lesões de MO e úlceras orais.
Avaliação da prescrição de medicamentos psicotrópicos pela rede pública municipal de saúde de Nova Floresta/PB
Authors: Morais Júnior Irineu Pereira de , Bezerra Karoline Gomes Dias , Oliveira Fernando de Sousa
Published: June 2023

Introdução: os medicamentos psicotrópicos são modificadores do sistema nervoso central, que agem nas doenças psiquiátricas com o objetivo de proporcionar cura ou estabilização destes quadros clínicos. Porém, o uso irracional dos psicotrópicos é considerado um grave problema de saúde pública, devido aos diversos prejuízos que essa prática causa a população mundial. Objetivo: o objetivo desse estudo foi avaliar a prescrição de medicamentos psicotrópicos dos usuários atendidos na farmácia básica do município de Nova Floresta/PB. Metodologia: estudo transversal, quantitativo e do tipo descritivo, durante os meses de outubro de 2016 a maio de 2017. As receitas e notificações de receitas foram avaliadas conforme as informações registradas pelo prescritor e na ação da dispensação dos medicamentos. Resultados: foram entrevistados 176 usuários de psicotrópicos no município de Nova Floresta-PB. Observou-se prevalência do sexo feminino (58,5%). A faixa etária prevalente foi de adultos que correspondeu a 72,7%, seguido de idosos (22,2%). Os psicotrópicos mais dispensados foram amitriptilina (15,4%), fenobarbital (14,4%), clonazepam (12,9%) e diazepam (9,9). Foram encontradas 21 prescrições com interações medicamentosas. Quanto às prescrições e o preenchimento correto da receita e notificação da receita, 5,7% das prescrições não apresentavam posologia e/ou data. Conclusão: observou-se a necessidade de sensibilização dos prescritores em relação à prescrição racional, assim como a necessidade de orientação por parte do farmacêutico junto aos usuários.
Acesso a medicamentos anti-hipertensivos pelos usuários de uma unidade ambulatórial
Authors: Matos Beatriz Emanuele Dos Santos De , Palmeira Catia  Suely , Macedo Tassia Teles Santana de , Varela Claudete Dantas da Silva
Published: June 2023

Objetivo: caracterizar o acesso aos medicamentos anti-hipertensivos pelas pessoas com hipertensão arterial atendidas em uma unidade ambulatorial. Metodologia: estudo descritivo, quantitativo, desenvolvido com 103 pessoas com hipertensão arterial em uso de anti-hipertensivos. Os dados foram coletados por meio de questionário com perguntas sociodemográficas, sobre tratamento e acesso aos medicamentos anti-hipertensivos. Utilizou-se a estatística descritiva e teste qui-quadrado de Pearson ou exato de Fisher para análise dos dados. Resultados: Predominou a faixa etária de 50-69 (68,9%), sexo feminino (85,4%) e raça/cor autodeclarada preta (46,6%). Quanto ao acesso aos anti-hipertensivos, 70,9% relataram ter acesso gratuito, 60,2% os obtêm nas unidades de saúde, 65,7% não referiram dificuldades na aquisição e 86,4% que tinham acesso total. Todos os participantes que tinham dificuldade econômica também tinham dificuldade de acesso aos anti-hipertensivos. Verificou-se associação significativa entre a dificuldade de acesso aos anti-hipertensivos com forma de acesso (total ou parcial), quantidade de drogas e disponibilidade do medicamento nas farmácias (p<0,005). Conclusão: observou-se que, embora a maioria dos participantes do estudo não encontre dificuldades para obtenção dos anti-hipertensivos nas farmácias das unidades básicas de saúde, ainda assim, existe uma parcela da população sem acesso total aos anti-hipertensivos de forma gratuita, sendo essencial melhorias dos programas de fornecimento de medicamentos.
Body composition and functional capacity in patients with Crohn's disease using Infliximab
Authors: Cruz Melissa Mercadante Santana , Slob Gabriela Lazzaron , Santos Cristiane Teixeira dos , Fontana Pâmela Dias , Ramos Junior Odery , Rabito Estela Iraci
Published: June 2023

Rationale: the use of anti-TNFα therapy, such as Infliximab (IFX), in patients with Chron's disease (CD) can lead to changes in body composition. Objective: to evaluate the body composition and functional capacity of patients with CD. Method: Cross-sectional study with patients with CD in clinical remission using IFX. For anthropometric evaluation, it was measured: weight, height and waist circumference; functional capacity by the hand grip strength test and body composition by bioelectric impedance. After that, the fat-free mass index and body fat index were calculated. Continouns variables were analyzed by Pearson or Spearman coefficient. For the multiple linear regression model, the time of use of IFX was used as a dependent variable and waist circumference, fat-free mass index, phase angle and handgrip strength were used as independent variables. Results: forty-three patients were evaluated, with an average of 43.1± 13.5 years of age. Of the total, 44.2% were overweight and 44.2% had increased waist circumference, 58.1% were classified with high to very high fat-free mass, 30.2% were below the adequacy parameter for fat-free mass index and 11.6% had reduced functional capacity. Conclusion: overweight, as well as increased waist circumference and body fat, is common in CD patients in clinical remission using Infliximab. Most patients had preserved functional capacity, however there wasn’t association with time of use of IFX.
Covid-19 e fatores associados em pessoas com 50 ou mais
Authors: Carvalho Viktor Wgo Pinto de , Cruz Simone Seixas , Rabelo Dóris Firmino , Guedes Ellen de Moraes
Published: June 2023

Introdução: a pandemia de COVID-19 se apresentou como uma intensa crise sanitária no mundo. Foram considerados os principais fatores de risco: idade avançada, ser do sexo masculino, presença de doenças crônicas, obesidade, fator racial/étnico, bem como piores condições socioeconômicas. Objetivo: o objetivo foi investigar a associação entre a COVID-19 e faixa etária, sexo, raça/cor, condições de saúde e sintomas. Metodologia: o estudo do tipo transversal, empregou dados dos prontuários e fichas de notificação compulsória de COVID-19 dos usuários assistidos na Unidade de Saúde. Para a análise dos dados, utilizou-se o pacote estatístico STATA® da StataCorp LLC, versão 14.2. A análise bivariada, segundo a presença de COVID-19, foi realizada com o emprego do teste qui-quadrado de Pearson ou teste exato de Fisher. A análise múltipla adotada foi a modelagem de regressão logística não-condicional. Resultados: a amostra incluiu 239 indivíduos e 38% apresentaram diagnóstico positivo para COVID-19. As alterações gustativas e olfativas foram sintomas mais frequentes entre indivíduos com resultado positivo para COVID-19, quando comparados àqueles sem a doença. O modelo de regressão logística, ajustado por sintomas apresentados e raça/cor, apresentou associação estatisticamente significante entre ser idoso e ter diagnóstico positivo para COVID-19 (OR: 2,23; IC95%: 1,01- 4,98). Conclusão: as alterações gustativas e a faixa etária foram as características associadas à COVID-19. O estudo valida a necessidade de elevação da qualidade dos registros gerados na Atenção Primária à Saúde, reforçando a necessidade de espaços com profissionais de saúde para que seja desenvolvida uma política de informação em saúde que fortaleça o Sistema Único de Saúde.
Impact of Neighborhood Characteristics on Safety Accident: Focus on Occurrence of Safety Accidents by Place in Busan
Authors: Lee Dalbyu
Published: June 2023

Small accidents are common in places closely related to public life. This study focused on the neighborhood, i.e., the space where our daily lives take place, and sought to identify the characteristics of the neighborhood affecting the occurrence of safety accidents. This study targeted Busan. Busan is highly likely to be vulnerable to safety concerns, as it has the highest proportion and increase rate of the elderly among large cities in Korea. Accordingly, this study classified neighborhoods with similar characteristics and observed the differences in safety accidents by place. Then, the causes of housing safety accidents (the most common type of safety accident) were identified from the neighborhood characteristics. The analysis demonstrated differences in the frequency of safety accidents by place according to the neighborhood type. In most neighborhoods, safety accidents in houses were the most common. In addition, the residents under the age of 14 and over 65, single-person households, housing types, and housing deterioration in a neighborhood were identified as statistically valid factors affecting the occurrence of housing safety accidents.
Improving the Linear Ratio Inspection Standard for Seismic Acceleration Sensor Output Voltages
Authors: Cho Sung-cheoul , Kim Min-jun , Yoon Seok-won , Won Jeong-hun
Published: June 2023

In this study, the seismic acceleration sensor inspection standard, which estimates the error rate of the sensor’s output voltage to test its linear ratio, was analyzed and an improved standard was proposed. Seismic acceleration sensors should be sensitive to small angular changes under seismic excitation; however, the existing inspection standard only calculates the error rates at 30°, 45°, 60°, and 90° angles. Thus, we proposed an improved inspection standard that measures error ratios in 5° increments from 0° to 90°. Since the linear ratio is determined by estimating the error rate between theoretical and measured output voltages, the error rates in the X, Y, and Z directions were analyzed at changing angles. The results indicate that the error rate increased at small installation angles, and that the error rate decreased gradually at smaller angular increments. The current inspection standard underestimated the actual error rate, as it represented only 40~50% of the average error rate measured by the 5° interval measurements. Therefore, the current inspection standard for estimating the linear ratios of seismic acceleration sensors should be improved to reflect the influence of variations in the error rate according to the angular increment.