bluuebunny/crossref_metadata_2025 huggingface dataset:
ENTPD1 (CD39) and NT5E (CD73) expression in human Medulloblastoma: an in silico analysis
Authors: Stefani Marco Antônio , Braganhol Elizandra , Santos Guilherme Tomasi , Suwa Samuel Masao , Cabeleira Daiane Dias , Andrade Guilherme Pamplona Bueno
Published: November 2023

Medulloblastoma is the most common malignant tumor in the pediatric population. Its classification has incorporated key molecular variations alongside histological characterization. CD39 (also known as ENTPD1) and CD73 (also known as NT5E), enzymes of the purinergic signaling pathway, act in synergy to generate extracellular adenosine, creating an immunosuppressive tumor microenvironment. Our study examined the expression of mRNA of these genes in previously described transcriptome data sets of medulloblastoma patient samples from the Cavalli Cohort (n =763). Survival distribution was estimated according to the Kaplan–Meier method using a median cut-off and log-rank statistics; p ≤0.05. The high expression of NT5E and ENTPD1 in non-WNT and non-SHH medulloblastoma Group 4 was significantly related to a lower survival (p =2.7e-04;p =2.6e-03). The high expression of NT5E in the SHH-activated group (n =172) was significantly related to greater overall survival (p =0.017), while high expression of ENTPD1 was significantly related to lower overall survival (p =7.8e-03). The expressions of NT5E and ENTPD1 were not significantly correlated with overall survival in the WNT group (n =63;p =0.212;p =0.101). The expression of NT5E in non-WNT and non-SHH medulloblastoma Group 3 (n =113) was not significantly related to survival of patients (p= 0.124), while high expression of ENTPD1 was significantly related to greater survival (p =0.034). This in silico analysis indicates that ENTPD1 (CD39) and NT5E (CD73) can be seen as potential prognostic markers and therapeutic targets for primary medulloblastomas in non-WNT and non-SHH Group 4.
Boosting biomass, lipid content, carbon sequestration capacity of microalgae cultivated with aggregation-induced emission light-converting films
Authors: Song Yingjie , Xie Lixuan , Zhang Xiuwen , Hu Zhangli , Li Shuangfei , Zhang Pengfei , Yang Xuewei
Published: November 2023

Microalgae are a kind of promising raw material for bioenergy production and carbon sequestration. To enhance cell growth and production efficiency, great efforts were made for exploring the appropriate intensity and quality of light to improve the synthesis of the value-added products. The aggregation-induced emission (AIE) material (Astrazon Brilliant Red 4G), active for converting blue-green light to red light (630–680 nm), was for the first time applied in the research to achieve high fatty acid yield with considerable carbon-neutral ability. After 10 days-incubation, it revealed that AIE light-converting films boosted the biomass of microalgae Scenedesmus obliquus, Phaeodactylum tricornutum, and Chlamydomonas reinhardtii by 13.00%, 28.00%, and 26.00%, and the total lipid contents increased by 34.60%, 17.74%, and 22.63%, with the carbon sequestration capacity raised by 17.18%, 38.89%, and 35.71%. Furthermore, AIE light-converting films promoted the accumulation of unsaturated fatty acids (UFAs) in all three microalgae. Our study demonstrated the potential application of AIE light-converting films for cultivating microalgae to capture high carbon dioxide for photosynthesize carbon-neutral energy and high-valued active compounds.
Factors associated with early inhospital adverse outcome following surgery for acute appendicitis in Uganda: A multicenter cohort
Authors: Sharif Farhan Yusuf , Abraha Demoz , Edyedu Isaac , Molen Selamo Fabrice , Mauricio William , Odong Samuel Oledo , Mugeni Michael , Muhumuza Joshua
Published: November 2023

Introduction:
The surgery for acute appendicitis has been associated with significant morbidity. This study aimed to determine the factors associated with early inhospital adverse outcome following surgery for acute appendicitis in Uganda.
Methods
This was a multicentre prospective cohort in which early inhospital outcome following surgery for acute appendicitis was assessed at 4 regional referral hospitals in Uganda. The occurrence of complications during the admission period was documented as well as the length of hospital stay. The factors associated with the adverse outcomes were determined using Poisson regression in SPSS version 26.
Results
Of the 102 patients that underwent surgery for acute appendicitis, majority were males 79(77.5%) with a mean age of 23.8(SD = 12.5) years. Perforated appendix was seen in 26 (25.5%) patients. Post-operative complications occurred in 21(20.6%) with the commonest being surgical site infection seen in 19(18.6%) patients. The median length of hospital stay was 3(IQR = 3–4) days with 43(42.2%) staying in hospital for more than 3 days. Presence of anemia (Hb < 8) (aRR = 1.376, CI = 1.159–1.634, P = < 0.001) and having a perforated appendix (aRR = 1.263, CI = 1.026–1.555, P = 0.027) were independently associated with occurrence of complications while being HIV positive (aRR = 1.379, CI = 1.105–1.721, P = 0.005) and having a perforated appendix (aRR = 1.258, CI = 1.019–1.554, P = 0.033) were independently associated with prolonged hospital stay.
Conclusion
Sensitization of the community about early presentation is still required in order to reduce the number of patients that present late, which will in turn reduce the risk of complications and length of hospital stay.
Higher order asymptotic crack-tip fields in simplified strain gradient elasticity
Authors: Solyaev Yury
Published: November 2023

Explicit representation for the higher order in-plane crack tip fields is derived by using Papkovich-Neuber stress functions within the simplified strain gradient elasticity (SGE). Presented solution has separable form and contains classical Williams' series as the particular case, when the gradient effects are negligible. The leading terms in the derived solution coincide with the previously known asymptotic solutions for the crack problems in SGE. The higher order terms have coupled amplitude factors and modified definitions for the angular distribution in comparison to the classical solution. Derived asymptotic fields are compared to the full-field numerical solution for the Mode I crack problem to quantify the amplitude factors and the zones of dominance for up to eight terms.
Environmentally acquired gut-associated bacteria are not critical for growth and survival in a solitary bee, Megachile rotundata
Authors: Brar Gagandeep , Floden Madison , McFrederick Quinn , Rajamohan Arun , Yocum George , Bowsher Julia
Published: November 2023

Background
Social bees have been studied extensively for their gut microbial symbiosis and its beneficial functions to the host’s health. But the significance of the environmentally acquired, non-symbiotic gut microbiota in solitary bees remain inconclusive. Solitary bee, Megachile rotundata females provision their offspring with pollen from ​​​various ​plant species harboring diverse microbes that colonizes larval gut. The Apilactobacillus is the most abundant microbe, but evidence regarding the effects of Apilactobacillus and ​other provision microbes on growth and survival ​are ​lacking. We ​hypothesized that the presence of intact microbial communities especially, Apilactobacillus would enhance larval and prepupal development, weight, and survival. Conversely, the absence of intact microbial communities was expected to have a negative impact on bee fitness. We reared larvae on pollen provisions with natural microbial communities (Natural pollen) or without microbes (Sterile pollen). We also assessed the impact of Apilactobacillus micheneri by adding it to both types of pollen provisions.
Results
Feeding larvae with sterile pollen + A. micheneri led to the highest mortality. Larval development was significantly delayed in groups fed with sterile pollen and sterile pollen + A. micheneri compared to the control. Interestingly, larval and prepupal weights did not significantly differ when they were given sterile pollen, sterile pollen along with A. micheneri, and natural pollen along with A. micheneri, in comparison to those fed only natural pollen. 16S rRNA gene sequencing found a dominance of endosymbiont Sodalis when A. micheneri was introduced to natural pollen.
Conclusion
This study highlights that reliance on non-host specific, environmental bacteria do not shape the fitness of M. rotundata and may hold true for other solitary bees. Apilactobacillus micheneri is not necessarily a beneficial microbe, and is harmful if present in abundance without other microbes. The presence of Sodalis with abundant A. micheneri suggests potential crosstalk between both, shaping bee nutrition and health. This perspective will enable us to gain a deeper understanding of the significance of environmentally acquired microbiomes for the survival, growth, and development of other solitary bees.
Ki-67, Syn, TTF-1 and nomogram for predicting overall survival in primary small cell carcinoma of the esophagus
Authors: Lyu Si-Mian , Tan Li-Yan
Published: November 2023

Background Esophageal cancer is the eighth most diagnosed cancer and the sixth most common cause of cancer death in the world. Primary small cell carcinoma of the esophagus (PSCCE) is a rare and highly malignant neuroendocrine tumor. Identifying reliable biomarkers is essential for predicting prognosis and inferring survival for patients.Methods Information on 68 patients diagnosed with PSCCE were collected. Cox proportional hazards regression is used to determine independent prognostic factors. A nomogram was constructed to predict survival and validated.Results A total of 68 PSCCE patients were enrolled in the construction cohort. Ki-67, Syn, TTF-1, AJCC-T stage, AJCC-N stage were independent prognostic factors. The nomogram was constructed, and the calibration curve showed satisfactory agreement. The C-index was 0.726(95% CI 0.720–0.732).Conclusion The correlation between Ki-67, Syn, and TTF-1 and patient diagnosis, prognosis, and survival was found, as well as a series of factors associated with the survival of patients with PSCCE. Based on the identified factors, a nomogram predicting the survival of patients with PSCCE was generated. The predictive model demonstrated satisfactory discrimination and calibration, which can inform survival estimation and individualized treatment decisions.
Assessing the difference between radiographic and non-radiographic axial spondylarthritis in Mexican patients: The influence of clinical, demographic, laboratory and clinimetric features
Authors: John Londono , Cesar Pacheco-Tena , Maria Santos Ana , Humberto Cardiel Mario , Rodríguez-Salas Gustavo , Igor Rueda , Sofía Arias-Correal , Mesa Cristian , Juliana Mantilla Marta , Camilo Santacruz Juan , Camilo Rueda Juan , Gilberto Vargas-Alarcón , Rubén Burgos-Vargas
Published: November 2023

Introduction/Objectives
To compare the demographic, clinical, and laboratory characteristics, disease onset, and clinical features of radiographic axial Spondyloarthritis (r-AxSpA) and non-radiographic axial Spondyloarthritis (nr-AxSpA) patients.
Method
All patients who attended outpatient spondylarthritis clinics at Hospital General de Mexico and the Instituto Nacional de la Nutrición, from 1998 to 2005, and met the spondyloarthropathies study group criteria (EESG) were included. In addition, patients were reclassified according to The Assessment of SpondyloArthritis international Society (ASAS) criteria. We selected patients with nr-AxSpA and r-AxSpA and compared clinical, demographic, and clinimetric variables.
Results
148 Mexican patients were included. 55 (37.2%) patients had r-AxSpA, and 70 (47.3%) had nr-AxSpA. Nr-AxSpA patients had a lower proportion of males (58.6% vs 78.2%, P < 0.05), lower HLA-B27 frequency (54.3%. vs. 92.7%, P < 0.05), older at disease onset (21 vs 16 years; P < 0.01), a higher frequency of infections at disease onset (32.9 .vs 9.1%, P < 0.05) than r-AxSpA. Logistic regression showed that the factors that most influenced the presentation of r-AxSpA were history of uveitis (OR 14, 95% CI 2.3 – 85), HLA-B27 (OR 7.97, 95% CI, 2.96 – 122), gender (male) (OR 6.16, 95% CI, 1.47 – 25.7), axial enthesopathy count (OR 1.17 95% CI, 1.03 – 1.33).
Conclusions
This study provides insight into the differences between nr-AxSpA and r- axSpA. Patients with r-AxSpA were mainly male, with a younger presentation age, a higher prevalence of HLA-B27, more history of uveitis, fewer episodes of dactylitis, more axial enthesopathy, and higher disease activity.
A Mendelian Randomisation Study to Examine the Causal Associations of Circulating Micronutrient Levels with Frailty Risk
Authors: Kuribanjiang Kaidiriyan , Min Yiping , Yan Shikang , Chen Simin , Aiheti Nuerbiyamu , Wupuer Abudunaibi , Wang Jie , Peng Xing , Li Yihan , Li Huilong , Dong Yiran , Fan Yuanlin , Yang Lei , Zhao Jianping
Published: November 2023

Background
There is some disagreement regarding the association between circulating micronutrient levels and the risk of frailty, according to prior observational research. Using a two-sample Mendelian Randomisation (TSMR) method, we explored the causal relationship between circulating micronutrient levels and the risk of frailty.
Methods
We gathered and screened instrumental variables (IVs) for eight circulating micronutrients, including selenium, zinc, vitamin B12, vitamin B6, folic acid, and vitamins C, D, and E, from published genome-wide association studies (GWAS) and the IEU OpenGWAS open database. Frailty summary data were generated from meta-analyses of genome-wide association studies (GWAS) found in the UK Biobank (n = 164,610) and Twin Gene (n = 10,616). We ran three studies: a main analysis using independently released GWAS data, a secondary analysis using IVs filtered from OpenGWAS data, and a meta-analysis of the findings from the two MR analyses.
Results
For circulating levels of the eight micronutrients, the pooled βs were − 0.02 (95% CI: -0.090, 0.001; vitamin C), -0.021 (95% CI: -0.045, 0.001; vitamin B12), 0.029 (95% CI: -0.013, 0.072; folic acid),-0.059 (95% CI: -0.183, -0.065; vitamin D), -0.011 (95% CI: -0.099, 0.075; vitamin E), 0.006 (95% CI: -0.047, 0.061; vitamin B6), 0.004 (95% CI: -0.007, 0.017; zinc) and − 0.005 (95% CI:-0.018, 0.008; selenium).
Conclusions
To summarize, there is no evidence for a connection between the occurrence of frailty and the eight micronutrients, suggesting that supplementation with these nutrients may have little therapeutic value in preventing frailty.
Chemical control of wheat sunn pest, Eurygaster integriceps Put. by the UAV sprayer
Authors: SHEIKHIGARJAN AZIZ , Safari Mahmoud , Ghazi Mostafa Mansour , Zarnegar Ali , Shahrokhi Shahram , Moein Saeed , Seyedin Peyman
Published: November 2023

The sunn pest is one of the most important pests of wheat crops in Iran and the Middle East. Chemical control by spraying is the most common method of controlling this pest. In general, ground sprayers that are currently used are not equipped with advanced spraying technologies and have low efficiency. This study aimed to investigate the efficacy of using an Unmanned Aerial Vehicles (UAV) sprayer for the chemical control of wheat sunn pest. The effectiveness, field capacity, and costs of chemical insecticide application were compared by the drone sprayer and the knapsack Micronair sprayer. We found that the chemical control effectiveness of the two spraying methods was not significantly different. Both drone sprayer and knapsack Micronair sprayer had an effectiveness percentage of more than 95%. The drone sprayer was better than the knapsack Micronair in terms of field capacity, insecticide dosage ml ha− 1, spray volume L ha− 1, reduced drift, and the probability of user contamination. The field capacity of the drone sprayer and the knapsack Micronair sprayer was 5.5 and 0.8 hectares per hour, respectively, and the spray volume was 14.6 and 30.0 L ha− 1, respectively.
Impact of Machine/Deep Learning on Additive Manufacturing: Publication Trends, Bibliometric Analysis, and Literature Review (2013-2022).
Authors: Chike Onuchukwu Godwin , Chin Yee Jian , Ahmad Norhayati , Ali Wan Fahmin Faiz Wan
Published: November 2023

This paper critically examined the research landscape and the impact of machine/deep learning on additive manufacturing (MDLAM) through publication trends, bibliometric analyses, and literature review. The Elsevier Scopus database was selected to identify and recover publications on MDLAM research published from 2013 to 2022 based on the Prisma approach. The recovered bibliographic data was analyzed using VOSViewer software to examine the co-authorship, keyword, and citation networks on the MDLAM research. Results showed that the publications output (and citations count) increased progressively from 1 (19) to 375 (980) from 2013 to 2022, which exhibits the high TC/TP ratio typically characteristic of highly impactful fields with future growth potentials. Analysis of top performers on the topic revealed that Prahalada K. Rao (US), Pennsylvania State University (US), and National Science Foundation (US) are the most prolific authors, affiliations, and funder of MDLAM research, respectively. Hence, the most active nation on MDLAM research is the United States (US), although China and the United Kingdom have also made significant contributions over the years. Keyword occurrence revealed the existence of several research hotspots with researchers' interests directed at basic research, optimization studies, industrial applications, and novel learning systems. The paper showed that MDLAM is a broad, complex, and impactful research area that will continue to experience scientific growth and technological development, mainly due to the growing demands for accurate computational methods for AM prototypes, processes, and products.
Bedeutung von Kunstkritik in wissenschaftlichen und populärwissenschaftlichen Medien
Authors:   , Lindenberg Charlotte
Published: November 2023

Allgemeines zur Rolle von Kunstkritik in Europa und den USA seit den 1980er Jahren; Vergleich der Zeitschriften frieze und Texte zur Kunst.
Sautrāntika vs. sarvāstivāda-vaibhāṣika – rani buddhistički prijepori o prirodi stvarnosti
Authors: Kardaš Goran
Published: November 2023

U članku se analizira i interpretira kritika specijalne dharmičke teorije ranobuddhističke škole sarvāstivāda-vaibhāṣika koju je poduzela škola sautrāntika. Posebna je pozornost posvećena kritici teorije o postojanju dharmi, elementarnih psihofizičkih data, u sva tri vremenska razdoblja. Na početku se prezentira opća buddhistička teorija o dvije istine koja pokušava legitimizirati tzv. filozofiju abhidharme kao »višeg učenja« u pogledu stvarnosti (teorija o dharmama) koja je tek rudimentarno prisutna u Buddhinim govorima. Potom se prelazi na sažeti prikaz ključnih ontoloških postavki sarvāstivāda-vaibhāṣike i na kritiku istih koju je poduzela škola sautrāntika. Zaključuje se da je sautrāntika svojom kritikom »vratila« buddhističku filozofiju na kolosijek čiste fenomenologije nakon pokušaja sarvāstivada-vaibhāṣike da Buddhino učenje interpretira u horizontu jedne realističke reduktivne ontologije.
Husserlov pojam čistog Ja
Authors: Jurić Andrija
Published: November 2023

Autor u članku analizira drugu fazu razvoja Husserlove fenomenološke egologije i prijelaz s neegološke na egološku fenomenologiju. Prihvaćajući neizbježnost čistog Ja kao fenomenološkog reziduuma transcendentalne epoché, nekonstituirane transcendencije u imanenciji i nositelja evidencije stava »Ja jesam«, ono se analizira u svojim glavnim aspektima – kao što su, među ostalim, Ja-pol i Ja-supstrat habitualnosti – te svojstvima koje posjeduje i ulogama koje igra u struji doživljaja čiste svijesti. Tako formulirano, čisto Ja bit će inkorporirano u kasne koncepte transcendentalnog ega i transcendentalne intersubjektivnosti. Bit će istaknuti i nedostaci takve egološke koncepcije svijesti, na koje adekvatno rješenje neće ponuditi ni neegološke teorije Husserlovih sljedbenika, što debatu o egološkom karakteru svijesti čini prisutnom i u suvremenoj filozofiji.
Šteta, sloboda i zarazne bolesti u filozofiji Johna Stuarta Milla
Authors: Cerovac Ivan
Published: November 2023

Ovaj rad analizira načelo štete Johna Stuarta Milla i njegovu ispravnu primjenu na procese izrade i evaluacije zakona, političkih odluka i mjera kojima se nastoji spriječiti širenje zaraznih bolesti. Interpretirajući Milla kao epistemičkog demokrata i epistemičkog liberala, rad se fokusira na Millova razmišljanja vezana uz procedure donošenja odluka koje su prikladne u vrijeme pandemije. Nadalje, rad raspravlja o ispravnoj podjeli epistemičkog i političkog rada, jednom od najvažnijih mehanizama koje Mill koristi za filtriranje narodne volje, i pokazuje kako nam Millovi argumenti mogu pomoći postići ravnotežu između epistemičkih i moralnih vrijednosti, odnosno između demokratskog i ekspertnog odlučivanja.
Epikurejske i skeptičke argumentativne strategije
Authors: Pavličić Jelena , Nišavić Ivan
Published: November 2023

U radu su skicirana ključna mjesta spoznajno-teorijske rasprave koja se odvijala u vrijeme najistaknutijih epikurejski i skeptički orijentiranih mislitelja. Istraživanje počinje s nekoliko povijesnih naznaka o Epikurovu doprinosu uspostavljanju spomenutih sporova te njegovoj motivaciji da problemu kriterija spoznaje dodijeli ključno mjesto. Istovremeno, u izvjesnoj mjeri, postat će jasno kako se rivalska skeptička misao razvijala pod utjecajem toga učenja. Namjera nije da se ta dva filozofska pristupa oslikaju u potpunosti, pa čak ni da se obuhvate njihove glavne odlike, nego da se ponude izvjesni uvidi u specifična područja njihovoga uzajamnog utjecaja koja su doprinijela tome da se na neočekivan način približe jedno drugom. Uslijed toga, vidjet ćemo i da, premda prilično raznorodne, te dvije helenističke pozicije odražavaju izvjesne sličnosti, prije svega, kada je riječ o poimanju prirode i cilja filozofskih istraživanja, u čemu se ogleda primjer sretnoga života, kao i odgovora na pitanje kojim bi se kriterijem trebalo rukovoditi ako želimo dostignuti takav život.
Influence factors on financial statements disclosure of Indonesian local governments
Authors: Supriono Supriono , Hariyani Eka , Paulus Silalahi Sem , Afriana Hanif Rheny , Aswar Khoirul
Published: November 2023

This study aims to examine the factors that affect the level of disclosure of local government financial reports. This paper uses such independent variables as budget expenditure of the local government, government size, and capital expenditure. The financial records of Indonesian local governments that have undergone audit by the supreme agency are analyzed in this study. For the 2020 timeframe, 485 local/city governments in Indonesia served as the research samples, and purposive sampling was employed as the sampling method. SPSS is utilized to support multiple linear regression, which is the data analysis method used in this study. The test findings revealed that budget expenditure (β = 0.274; p < 0.05), government size (β = 0.216; p < 0.05), and capital expenditure (β = 0.178; p < 0.05) have a significant effect on the level of local government financial statements disclosure. It is envisaged that the findings of this study would enable local governments, particularly districts or cities, to better maximize the disclosure of local government financial statements in compliance with government regulation. Local governments will be able to open up information that is easily accessible with the aid of ever-improving technology.
A Combination of CPI-0610 and SAHA Induces Apoptosis through STAT3 and p38 Signalling Pathways in Diffuse Large B-cell Lymphoma Cells
Authors: Xu Linyan , Jiao Jun , Liu Mengdi , Qin Yuanyuan , Zhang Meng , Yan Dongmei , Xu Kailin , Sang Wei
Published: November 2023

Background::

Although immunotherapies have greatly improved diffuse large B-cell
lymphoma (DLBCL) prognosis, a proportion of patients remain to be relapsed or refractory. Therefore,
the identification of novel therapeutic targets and drugs is urgently required. Inhibition of the
bromodomain and extra-terminal (BET) proteins has been a promising therapeutic strategy for
various haematologic cancers. CPI-0610 is a potent and selective BET inhibitor. The effects of
CPI-0610 in DLBCL cells have not been reported yet.

Aims::

The aim of this study was to assess the effects of CPI-0610 in DLBCL and its underlying
mechanisms.

Methods::

DLBCL cells were treated with CPI-0610, followed by measuring cell viability, cell cycle,
apoptosis, autophagy, and specific cell signaling pathways. Moreover, immunodeficient mice
were engrafted with SUDHL2 cells and then treated with CPI-0610 for analysis of tumor burden.
We also analyzed the synergistic effect of CPI-0610 with histone deacetylase inhibitor suberoylanilide
hydroxamic acid.

Results::

The present study demonstrated that CPI-0610 displayed cell cytotoxicity by arresting
the G1 cell cycle and inducing endogenous and exogenous apoptotic pathways. Additionally,
CPI-0610 decreased BRD4 and c-Myc expressions and affected MAPK, JAK/STAT, and AKT signalling
pathways in human DLBCL cells. An in vivo experiment exhibited that CPI-0610 decreased
the primary tumour growth of the DLBCL xenograft model. Furthermore, the use of
CPI-0610 in combination with suberoylanilide hydroxamic acid exhibited a specific synergistic effect
in inducing apoptosis through the regulation of STAT3 and p38.

Conclusion::

Targeting BET may be an effective therapeutic strategy and potentiated by a combination
with histone deacetylase inhibition in DLBCL.
A Comprehensive Review on Biotransformation, Interaction, and Health
of Gut Microbiota and Bioactive Components
Authors: Zhang Lin , Ma Xiao-Gen
Published: November 2023

Background::

The relationship between gut microbiota and bioactive components has
become the research focus in the world. We attempted to clarify the relationship between biotransformation
and metabolites of gut microbiota and bioactive components, and explore the
metabolic pathway and mechanism of bioactive ingredients in vivo, which will provide an important
theoretical basis for the clinical research of bioactive ingredients and rationality of drugs,
and also provide an important reference for the development of new drugs with high bioavailability.

Methods::

The related references of this review on microbiota and bioactive components were
collected from both online and offline databases, such as ScienceDirect, PubMed, Elsevier, Willy,
SciFinder, Google Scholar, Web of Science, Baidu Scholar, SciHub, Scopus, and CNKI.

Results::

This review summarized the biotransformation of bioactive components under the action
of gut microbiota, including flavonoids, terpenoids, phenylpropanoids, alkaloids, steroids, and other
compounds. The interaction of bioactive components and gut microbiota is a key link for drug efficacy.
Relevant research is crucial to clarify bioactive components and their mechanisms, which involve
the complex interaction among bioactive components, gut microbiota, and intestinal epithelial
cells. This review also summarized the individualized, precise, and targeted intervention of gut microbiota
in the field of intestinal microorganisms from the aspects of dietary fiber, microecological
agents, fecal microbiota transplantation, and postbiotics. It will provide an important reference for
intestinal microecology in the field of nutrition and health for people.

Conclusion::

To sum up, the importance of human gut microbiota in the research of bioactive
components metabolism and transformation has attracted the attention of scholars all over the
world. It is believed that with the deepening of research, human gut microbiota will be more
widely used in the pharmacodynamic basis, drug toxicity relationship, new drug discovery, drug
absorption mechanism, and drug transport mechanism in the future.
Nauczyciel w dobie pandemii
Authors: Bielak Paulina , Gajewska Martyna , Lisewska Iwona
Published: November 2023

W czasach pandemii nauczyciel na każdym poziomie edukacyjnym postawiony jest przed wieloma nowymi wyzwaniami. W poniższym artykule zaprezentowano obowiązki oraz problemy z jakimi w obecnych czasach musi mierzyć się grono pedagogiczne. Omówiono pokrótce badania, które przedstawiały najczęściej występujące problemy podczas zdalnego nauczania. Przedstawiono kompetencje, które potrzebne są w pracy nauczyciela oraz te, które potrzebne są podczas nauki online. Zaprezentowano potrzeby uczniów w tym specyficznym czasie oraz problemy środowiska edukacyjnego związanego ze stresem.
Obszary i formy współpracy przedszkola i szkoły z rodzicami
Authors: Kubiak-Skrzyńska Magdalena
Published: November 2023

W poniższym artykule zaprezentowano obszary i formy współpracy z rodzicami, które są niezbędne do stworzenia optymalnych warunków rozwoju dziecka. Realizacja tychże form, pozwoli na zrealizowanie w pełni wymagania stawianego placówce przez ustawodawcę, tak, by rodzice stali się partnerami placówki, współdecydowali w jej sprawach i uczestniczyli w podejmowanych działaniach, na rzecz rozwoju dzieci, a placówka by pozyskiwała i wykorzystywała opinie rodziców do swojej pracy.
Rozwój przedsiębiorczości społecznej w czasie pandemii COVID-19
Authors: Sicińska Katarzyna
Published: November 2023

Głównym celem opracowania jest zaprezentowanie działań podejmowanych przez przedsiębiorców społecznych podczas pandemii COVID-19 w Polsce i na świecie oraz odpowiedź na pytanie, czy pandemia okazała się dla tych podmiotów szansą na rozwój. Realizacji celu posłużyła analiza krajowych i zagranicznych wtórnych źródeł informacji dotyczących przedsiębiorstw społecznych i ich sytuacji w okresie kryzysu wywołanego przez pandemię. Wyniki przeprowadzonej analizy doprowadziły do kilku interesujących wniosków. Przede wszystkim zauważono, że zaangażowanie ze strony przedsiębiorców społecznych podczas pandemii okazało się niezbędne i niezwykle pomocne w rozwiązywaniu problemów społecznych. Dodatkowo pokazano, że przedsiębiorcy społeczni właściwie rozpoznali pojawiające się w otoczeniu problemy i potrzeby społeczne oraz właściwie na nie zareagowali, a pandemia okazała się dla nich szansą na rozwój i poszerzenie działalności. Zwrócono również szczególną uwagę na szereg koniecznych do wprowadzenia usprawnień, które mogą pomóc w popularyzacji modelu przedsiębiorczości społecznej, polepszyć jego wizerunek, zwiększyć finansowanie i zainteresowanie tego typu działalnością innych podmiotów.
Invloedrijke stemmen. Patiëntenverhalen uit het Johns Hopkins ziekenhuis rond 1900
Authors: Gijbels Jolien
Published: November 2023

Omstreeks 1900 bevonden vrouwelijke patiënten zich in een ongelijkwaardige onderhandelingspositie in Amerikaanse ziekenhuizen. Toch daagden zij de ideeën en praktijken van hun artsen op verschillende manieren uit. Aan de hand van patiëntenverhalen werpt Jolien Gijbels licht op de invloed van vrouwen op de gynaecologen in het Johns Hopkins ziekenhuis in Baltimore.
A Scoping Review on the Clinical Supervision and Mentoring for Nurses in Maternal and Child Health
Authors: Park Bohyun , June Kyung Ja , Jo Yeonjae , Yu Jungok
Published: November 2023

Purpose: This scoping review aimed to identify application methods, effectiveness, facilitating factors, and obstacles to clinical supervision for nurses in maternal and child health and to understand its discriminatory characteristics compared to mentoring.Methods: This study was based on the scoping review methodology and consisted of six stages: (1) identifying research questions; (2) identifying relevant studies (search strategy); (3) study selection; (4) charting of the data; (5) collating, summarizing, and reporting the results; and (6) consultation. From April to July 2022, 1,323 studies were searched in PubMed, CINAHL, Cochrane, and Open Gray, and finally eleven studies were selected through the literature selection process.Results: Because clinical supervision aimed to strengthen the professional capabilities of nurses, reflective practice was applied. However, mentoring was designed to acquire knowledge or skills that can be applied directly in practice. Therefore, indicators to measure the effects of clinical supervision consisted of psychosocial factors, such as job satisfaction and exhaustion, but the effects of mentoring were evaluated primarily using knowledge levels and skills. The model, which is applied mainly in clinical supervision, reflects the restorative function. When applying clinical supervision and mentoring, listening, supportive environment, and accessibility were identified as facilitating factors, while criticism, lack of time and space, and excessive workload were identified as obstacles.Conclusions: Time and space must be secured to provide effective clinical supervision. The confidentiality of the supervisee must be guaranteed, and sufficient information must be provided in advance so that nurses can accurately recognize the clinical supervision process. Finally, a policy for institutionalizing clinical supervision should be supported to ensure its applicability and sustainability.
A comparative study of the effect of nanoparticles and antibiotics
on the antimicrobial susceptibility of antibiotics for some bacteria
isolated from wounds and burns infections.
Authors: Radeef Yusra A. , Kadhum AL-Mari Anmar Mahdi
Published: November 2023

This study aimed to investigate the isolation and identification of potential bacteria
present in burns and wound infections. 100 pus types were taken from many patients who existed in the hospital of Babylon province from November 2021 to
February 2022; the positive culture was 80% of the total isolates, while the negative culture was 20% of the total isolates. After the macroscopic, microscopic and
biochemical tests, the bacteria were isolated from burn and wound swabs. Antibiotic susceptibility testing of the isolates was done using the disc diffusion method
in conformity with McFarland standards. MDR of different types of antibiotics was
exhibited from bacteria isolated in actual research. Statistical analysis using chisquare test The central objective of this research is to use different concentrations
of Zinc oxide nanoparticles to obtain the optimum antibacterial concentration.
Males (37.5%) and females (62.5%), with ages ranging from 5 to 55 years. The
high percentage was less than ten years old, while the lowest was between (and
50_60). Where Gram-negative bacteria were most common, the concentration of
Zinc oxide nanoparticles was 100 μg/ml. 150 μg/ml affects gram-positive and
gram-negative growth by measuring the diameter of the inhibition zone on the
growth culture that is artificial to Gram-positive and Gram-negative bacteria
throughout the measuring inhibition zone around the wells. We observed that the
diameter of the inhibition zone increased in concentration (150) μg/ml more than
the concentration (100) μg/ml. The study showed women of positive growth and
the ages compared to males. Multi-Drug Resistance bacteria. Zinc oxide nanoparticles have critical applications as they are antibacterial and effectively dress for
burns and wounds .
Keywords: Gram-positive Bacteria, Gram-negative bacteria, Wounds, Burns, Antimicrobial sensitivity, Multi-Drug Resistant, nanoparticles.
Some characteristics of tomato lycopene and the possibility of its use in fresh
milk fortification
Authors: WH Al-Mudhafar Adnan , A-R J Alikhan Ahmed
Published: November 2023

The results showed that lycopene dye was highly effective in reducing the
peroxide number value, as adding 1 mg of the dye to fresh milk led to the lowest
peroxide number (0.497 - 2.483) compared to (0.543 - 4.943) of milk with
artificial antioxidant BHT and milk without addition, which scored (0.567 -
11.997) for eleven days of storage at 4 °C. Lycopene dye reduced the values of
thiobarbituric acid (TBA) in milk stored at 4°C for seven days compared to
regular milk without addition. The results also proved that the dry lycopene dye
extracted from the fruits of the tomato plant, when dissolved in buffer solutions
with different pHs ranging from (3-8), did not have a significant effect on the
dyes, as the pH factor on the measured wavelengths ranged from 370.0-370.5 As
for the effect of the number of days factor, it ranged from 369.7-370.6
nanometers. It was found that low temperatures did not affect the lycopene
pigment extracted from tomato fruits. The results of the sensory evaluation
indicate that the total sum of sensory evaluation scores (taste, texture, and
appearance) was higher (23.8) in the treatment of lycopene-free milk compared to
the milk fortified with lycopene tomato, which scored 22.6.
Keywords: plant pigments, lycopene, fresh milk
Acceptability, Effectiveness, and Roles of mHealth Applications in Supporting Cancer Pain Self-Management: Integrative Review (Preprint)
Authors: Wu Weizi , Graziano Teresa , Salner Andrew , Chen Ming-Hui , Judge Michelle P , Cong Xiaomei , Xu Wanli
Published: November 2023

BACKGROUND

 Cancer pain remains highly prevalent and persistent throughout survivorship, and it is crucial to investigate the potential of leveraging the advanced features of mobile health (mHealth) apps to empower individuals to self-manage their pain.

OBJECTIVE

 This review aims to comprehensively understand the acceptability, users’ experiences, and effectiveness of mHealth apps in supporting cancer pain self-management.

METHODS

 We conducted an integrative review following Souza and Whittemore and Knafl’s 6 review processes. Literature was searched in PubMed, Scopus, CINAHL Plus with Full Text, PsycINFO, and Embase, from 2013 to 2023. Keywords including “cancer patients,” “pain,” “self-management,” “mHealth applications,” and relevant synonyms were used in the search. The Johns Hopkins research evidence appraisal tool was used to evaluate the quality of eligible studies. A narrative synthesis was conducted to analyze the extracted data.

RESULTS

 A total of 20 studies were included, with the overall quality rated as high (n=15) to good (n=5). Using mHealth apps to monitor and manage pain was acceptable for most patients with cancer. The internal consistency of the mHealth in measuring pain was 0.96. The reported daily assessment or engagement rate ranged from 61.9% to 76.8%. All mHealth apps were designed for multimodal interventions. Participants generally had positive experiences using pain apps, rating them as enjoyable and user-friendly. In addition, 6 studies reported significant improvements in health outcomes, including enhancement in pain remission (severity and intensity), medication adherence, and a reduced frequency of breakthrough pain. The most frequently highlighted roles of mHealth apps included pain monitoring, tracking, reminders, education facilitation, and support coordination.

CONCLUSIONS

 mHealth apps are effective and acceptable in supporting pain self-management. They offer a promising multi-model approach for patients to monitor, track, and manage their pain. These findings provide evidence-based insights for leveraging mHealth apps to support cancer pain self-management. More high-quality studies are needed to examine the effectiveness of digital technology–based interventions for cancer pain self-management and to identify the facilitators and barriers to their implementation in real-world practice.
High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial (Preprint)
Authors: Rojas-Anaya Hector , Kapur Akshat , Roberts Graham , Roland Damian , Gupta Atul , Lazner Michaela , Bayreuther Jane , Pappachan John , Jones Christina , Bremner Stephen , Cantle Fleur , Seddon Paul
Published: November 2023

BACKGROUND

Acute severe asthma (ASA) is a leading cause of hospital attendance in children. Standard first-line therapy consists of high-dose inhaled bronchodilators plus oral corticosteroids. Treatment for children who fail to respond to first-line therapy is problematic: the use of intravenous agents is inconsistent, and side effects are frequent. High-flow humidified oxygen (HiFlo) is widely used in respiratory conditions and is increasingly being used in ASA, but with little evidence for its effectiveness. A well-designed, adequately powered randomized controlled trial (RCT) of HiFlo therapy in ASA is urgently needed, and feasibility data are required to plan such an RCT. In this study, we describe the protocol for a feasibility study designed to fill this knowledge gap.

OBJECTIVE

This study aims to establish whether a full RCT of early HiFlo therapy in children with ASA can be conducted successfully and safely, to establish whether recruitment using deferred consent is practicable, and to define appropriate outcome measures and sample sizes for a definitive RCT. The underlying hypothesis is that early HiFlo therapy in ASA will reduce the need for more invasive treatments, allow faster recovery and discharge from hospital, and in both these ways reduce distress to children and their families.

METHODS

We conducted a feasibility RCT with deferred consent to assess the use of early HiFlo therapy in children aged 2 to 11 years with acute severe wheeze not responding to burst therapy (ie, high-dose inhaled salbutamol with or without ipratropium). Children with a Preschool Respiratory Assessment Measure score ≥5 after burst therapy were randomized to commence HiFlo therapy or follow standard care. The candidate primary outcomes assessed were treatment failure requiring escalation and time to meet hospital discharge criteria. Patient and parent experiences were also assessed using questionnaires and telephone interviews.

RESULTS

The trial was opened to recruitment in February 2020 but was paused for 15 months owing to the COVID-19 pandemic. The trial was reopened at the lead site in July 2021 and opened at the other 3 sites from August to December 2022. Recruitment was completed in June 2023.

CONCLUSIONS

This feasibility RCT of early HiFlo therapy in children with ASA recruited to the target despite major disturbances owing to the COVID-19 pandemic. The data are currently being analyzed and will be published separately.

CLINICALTRIAL

International Standard Randomised Controlled Trial Number Registry ISRCTN78297040; https://www.isrctn.com/ISRCTN78297040

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/54081
The Factors Influencing the Idea Recognition of Open Innovation Platforms: Take LEGO Ideas as an Example
Authors: Wang Fudong , Gao Wei , Liu Fengtao
Published: November 2023

With the influx of users posting their ideas to Open Innovation Platforms (OIPs), there has been widespread interest in how companies screen high-quality ideas. Most of the existing literature on idea quality focuses on the adoption of ideas by companies, while ignoring the recognition among users. Based on the ideas posted by users of LEGO Ideas, this study first analyzes the influence of users’ social learning and social network on their innovation ability, and then further investigates the influence of idea authors’ innovation ability and idea content’s characteristics on idea recognition based on signal theory. The findings suggest that more challenging social learning as well as weighted indegree and betweenness centrality of social network positively affect users’ innovation ability and weighted outdegree of social network negatively affects users’ innovation ability. Meanwhile, idea authors’ innovation ability and the number of pictures, text length, richness, popularity, and emotional polarity of idea content positively affect idea recognition. Distinct from the existing literature, this paper focuses on idea recognition among users, delves into the influence of social learning and social network on users’ innovation ability, and integrates the study of factors influencing users’ innovation ability into the study of factors influencing idea recognition.
On the Path of Curriculum Ideological and Political Reform in College Chinese
Authors: Hu Feifan
Published: November 2023

As a new educational concept, "curriculum ideology and politics" has been widely concerned by the academic circle, showing a rapid popularity in colleges and universities. At the same time, under the high attention and continuous promotion of the state, colleges and universities across the country continue to accelerate the construction and development of curriculum ideology and politics. College Chinese course, as a public basic course set by colleges for non-Chinese language and literature majors, has the characteristics of ideology, tool and humanity, has the unique advantages of combining with curriculum ideological and political construction, and is an important position and advantageous platform to promote the construction of college curriculum ideological and political construction. Therefore, we should give full play to its important value and role in cultural identity, ideological identity and value identity, give full play to the leading in curriculum ideological and political reform, strengthen teachers' awareness of carrying out curriculum ideological and political education, optimize teaching content, dig deep into the ideological and political elements in college Chinese curriculum, pay attention to the combination of theory and practice, Adhere to the unity of explicit education and implicit education, and constantly improve the quality of college personnel training.
Communify: Website for Intra-College Communication
Authors: Mande Smita
Published: November 2023

Abstract: This research paper explores a college website for the college community website - Communify. The main goal of the website is to provide an alternative to other social media platforms where all the notices get cluttered and important notices are often overlooked by the students. The website is designed for the dispersal of college notices, activities as well as activities and events of various college clubs in a systematic and organized manner. The website is also designed such that and academic activities and events are less mundane and more interactive to keep students engaged on the website.
Nanometal Decorated Carbon Nanomaterials Generated from Agro-Waste as Excellent Adsorbent for Toxic Metal Ions
Authors: Mukherjee Bholanath T. , Nandapure Arati D. , Jayswal Pooja O.
Published: November 2023

Abstract: The effluent water contains heavy metals, dyes and other toxic chemicals which are harmful for humans and environments. By using adsorption technique, one can easily remove most of the toxic materials including metal ions. Adsorption depend upon the physical interaction between adsorbate and adsorbent. Due to specific structural properties, Carbon nanomaterials are used as the adsorbents for removal of metal ions present in effluents as well as for purification of water. In the present work, Pb2+ and Cr6+ ions were removed from aqueous medium using nanomaterials which is a nanocomposite of Carbon nanomaterials decorated with nanometal (Cu). The Carbon nanomaterials were prepared from agro-wastes sugarcane bagasse. It can remove metal ions in the range of 85 to 90 % from solution having low concentrations of 12-14 ppm. Adsorption of metal ions were found to depend on the pH of the aqueous media. It can show maximum adsorption at pH 6 for Pb2+and at pH 1-3 for Cr6+ . Morphological features of nanoparticles were analyzed using SEM, HRTEM, Raman, XRD and Specific surface area was determined using BET
Fingerprint Based Exam Hall Authentication
Authors: Sekhar Dr. P. Chandra , Anagani Bhavani , Reshmi  , Aruna  , Priya Sai
Published: November 2023

Abstract: This biometric security system is more accurate than the conventional password-based method and is focused on the needs of humans. Despite being one of the earliest biometric procedures, verification is still the most popular because to its ease of use and consistent accuracy. It is necessary to install fingerprint detection equipment in every exam room, office, and classroom. To signify their attendance in class or during the exam, pupils would have to swipe their finger across the sensor. The database contains the student records so they may be verified. When a pupil swipes their finger across the scanner, an assessment is conducted for them; the gadget scans the fingerprint module's finger patterns and compares the information with the data