bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience with Levilimab in Ambulatory Practice (in the Provision of Primary Medical and Social Care)
Authors:   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia, Slusar A.A. , Muraveva P.A. ,   Institute of Biological Systems named after Berezin Sergei, Moscow, Russia, Balyasin M.V. ,   Peoples Friendship University of Russia, Moscow
Published: May 2023

Purpose: The aim of the study was to confirm the effectiveness of the drug at the pre–hospital stage to prevent the development of severe forms of infection requiring hospitalization. Materials and methods: To collect clinical and epidemiological data in the 2021-2022 season, an active prospective cohort study approach was used to assess the efficacy and safety of levilimab in patients with confirmed new coronavirus infection in outpatient settings. The comparison involved patients who received 1 or 2 doses of levilimab in combination with standard therapy (n=283) and patients who voluntarily refused to use levilimab and received only standard therapy (n=223). Results: According to the study, patients who received levilimab (1 or 2 doses) had a lower frequency of hospitalizations compared to patients who had standard therapy taking into account the same laboratory indicators of CRP (mg/l) in the two study groups. Younger patients (under 30 years of age) had a much lower risk of hospitalization than older patients, regardless of the use of levilimab. There is also a direct correlation between the age of patients and their risk of hospitalization. It was revealed that with the refusal of the use of the Levilimab monoclonal antibody, an increase in age for every 10 years affected an increase in the risk of hospitalization by up to 10%. Patients after 50 years who refused levilimab and took standard therapy were hospitalized several times more often than patients with the same therapy who performed levilimab injection. Patients who received one dose (162 mg) or two doses (324 mg) of the drug had the best effect of the therapy – they had the lowest frequency of hospitalizations compared to patients who voluntarily refused the administration of a monoclonal antibody. When refusing to use levilimab, the probability of hospitalization increased to 60%, which was crucial for those patients who did not have a single injection.
Business Ethics in E-Commerce – Legal Challenges and Opportunities
Authors: Channak Zaki Mahmed
Published: May 2023

Background: This paper deals with the ethical limitations of e-commerce. The aim is to discover areas where the protection is not granted as users would expect and to make proposals for improvement. The authors will begin the paper by proposing the market of e-commerce and how it is directly linked to society’s daily life. The method adopted for the legal perspective is case studies, where the Kingdom of Saudi Arabia’s (KSA) legal context will be explored. In the end, the paper will answer two main questions: What are the ethical challenges facing the issue of data protection in electronic commerce? What are essential legal frameworks that regulate the subject of data protection in Saudi Arabia?
Methods: The normative method is applied to identify the main legislations used in e-commerce and data protection, especially regarding big data regulations. A case study analysis is also used where KSA legislation is investigated.
Results and Conclusions: The authors saw that e-commerce is an insecure place to protect customer data. This data is stored electronically, so it is very easy to steal it in addition to the use of this data by companies without the permission of the customer. Research proves that laws are unable to keep pace with technological developments and are unable to provide effective protection for data stored in the cloud.
Perancangan E-CRM Untuk Meningkatkan Pelayanan Dan Loyalitas Pelanggan Pada Intan Laundry
Authors: Wulandari Dini , Azhar Zulfi , Syafnur Afdhal
Published: May 2023

Abstract :  At this time there are many laundries operating in the community. Competition is quite large in the laundry industry, offering relatively the same services with differences in service and laundry processing time. Intan Laundry wants to provide the best service for its customers, but in the current conditions there has been a significant decline in demand and increasing complaints about the end result of laundry services. For this reason, a web-based service information system is needed to increase loyalty using the E-CRM method which can manage laundry online. This E-CRM application design system was built to make it easier to promote laundry services more efficiently and to be able to extend this laundry to customers to be able to manage and get more customers by placing orders online.Keywords: Customer Relationship Management; laundry; loyalty; online; clothingAbstrak : Pada saat ini sudah banyak laundry yang beroperasi di kalangan masyarakat. Persaingan cukup besar di industri laundry, menawarkan jasa relatif sama dengan  perbedaan pada pelayanan dan waktu pengerjaan laundry. Intan Laundry ingin memberikan pelayananan yang terbaik bagi customernya, namun dalam kondisi sekarang ini terjadinya penurunan permintaan yang cukup besar dan meningkatnya keluhan terhadap hasil akhir jasa laundry. Untuk itu diperlukan suatu sistem informasi pelayanan berbasis web untuk meningkatkan loyalitas dengan menggunakan metode E-CRM ini yang dapat mengelola laundry secara online. Sistem rancangan aplikasi E-CRM ini dibangun untuk mempermudah  mempromosikan jasa laundry dengan lebih efisien serta dapat memperluas laundry ini kepada pelanggan untuk dapat mengelola serta mendapatkan pelanggan yang lebih banyak dengan melakukan pemesanan secara online.Kata kunci :  Customer Relationship Management; laundry; loyalitas; online, pakaian.
SPK DALAM MENENTUKAN PRODUK PROMO MENGGUNAKAN METODE MFEP PADA TOKO FUJI KISARAN
Authors: Purba Elisa Maysaroh , Syafwan Havid , Christy Tika
Published: May 2023

Abstact: The E-Report system is very important to be given to every whistleblower who has experienced defamation has met the requirements based on laws and regulations. The  Asahan Regency Police still uses word processing Software, such as Microsoft Office Word for the E-Report System decision letter process. This allows for delays in producing decision letters and reports of the E-Report System. In this study, UML was used as the system modeling language, MySQL as the database, and PHP as the programming language. The result of this study is an electronic application of the E-Report System that can be used by Information staff easily and more efficiently to produce decision letters and reports of the E- Report System. Meanwhile, the whistleblower can input data and upload the requirements of the E-Report System without the need to come to the Asahan Regency Police. Keyword: E-Report System; Electronic Application; MySQL; PHP.  Abstrak: Sistem E-Lapor sangat penting diberikan kepada setiap pelapor yang telah mengalami pencemaran nama baik telah memenuhi persyaratan berdasarkan peraturan perundang – undangan. Polres Kabupaten Asahan masih menggunakan Software pengolah kata, seperti Microsoft Office Word untuk proses surat keputusan Sistem E-Lapor. Hal ini memungkinkan terjadinya keterlambatan untuk menghasilkan surat keputusan dan laporan Sistem E-Lapor. Dalam penelitian ini menggunakan UML sebagai bahasa pemodelan sistem, MySQL sebagai database, dan PHP sebagai bahasa pemrogramannya. Hasil dari penelitian  ini adalah aplikasi elektronik Sistem E-Lapor yang dapat digunakan oleh staf Informasi dengan mudah dan lebih efisiensi untuk menghasilkan surat keputusan dan laporan Sistem E- Lapor. Sedangkan pelapor dapat melakukan input data dan upload syarat Sistem E-Lapor tanpa perlu datang ke Polres Kabupaten Asahan. Kata Kunci: Sistem E-Lapor; Aplikasi Elektronik; MySQL; PHP.
PENERAPAN TEKNIK SERVQUAL DALAM MENGUKUR TINGKAT PELAYANAN PT. TRANS SUMATRA ANDALAN KISARAN
Authors: Kurnia Jaka , Yusda Riki Andri , Nofitri Rika
Published: May 2023

Abstract: PT. Trans Sumatra Andalan Kisaran is located at Jalan Ahmad Yani No. 74, East Range, Asahan District. PT. Trans Sumatra Andalan Kisaran serves battery changes, oil changes, general check-ups, tune-ups, and more. Based on data on customer complaints from January to December 2020, this could potentially become a problem in the future, such as the length of service time at the customer reception counter that customers receive is longer than the estimated time in the SOP of PT. Trans Sumatra Mainstay Range, which is 10 minutes, the process of taking spare parts takes a long time after the customer has finished inspecting the car, PT. Trans Sumatra Andalan Kisaran must provide services according to the wishes and understand the needs of customers. mechanics and other officers help if there are customer problems, mechanics take action appropriately and quickly, so it is necessary to evaluate so that efforts to improve the quality of PT. Trans Sumatra Andalan Range and seeing the results of the questionnaires given by customers takes a long time to determine the quality of the service. Based on this, researchers want to examine customer satisfaction with the services of PT. Trans Sumatra Mainstay Range . Based on the initial research survey, it is known that customer satisfaction with vehicle service and also product sales is not stable from time to time. Method Keywords: Measuring Service Level; Servqual Technique.  Abstrak: PT. Trans Sumatra Andalan Kisaran berlokasi di Jalan Ahmad Yani No. 74, Kisaran Timur, Kabupaten Asahan. PT. Trans Sumatra Andalan Kisaran melayani ganti aki, ganti oli, general check up, tune up, dan lainnya. Berdasarkan data keluhan pelanggan dari bulan Januari sampai Desember 202 dapat berpeluang menjadi permasalahan di masa mendatang seperti lama waktu layanan di loket penerimaan pelanggan yang diterima pelanggan lebih lama dari waktu estimasi yang ada pada SOP PT. Trans Sumatra Andalan Kisaran yaitu 10 menit, proses pengambilan spare part  memakan waktu lama setelah pelanggan selesai melakukan pemeriksaan mobil, pihak PT. Trans Sumatra Andalan Kisaran harus memberikan pelayanan sesuai dengan keinginan dan memahami kebutuhan pelanggan. mekanik dan petugas lainnya membantu  jika ada permasalahan pelanggan, mekanik melakukan tindakan secara tepat dan cepat, sehingga perlu dilakukan evaluasi agar upaya peningkatan kualitas layanan PT. Trans Sumatra Andalan Kisaran dan melihat hasil kuesioner yang diberikan pelanggan memakan waktu lama dalam menentukan kualitas pelayanan tersebut. Berdasarkan  hal tersebut, peneliti ingin meneliti kepuasan pelanggan terhadap pelayanan PT. Trans Sumatra Andalan Kisaran . Berdasarkan survei awal penelitian diketahui bahwa kepuasan pelanggan terhadap Service kendaraan dan juga penjualan produk tidak stabil dari waktu ke  waktu. Kata Kunci : Mengukur Tingkat Pelayanan; Teknik Servqual.
PERANCANGAN E-CRM PENJUALAN PRODUK PADA KAKA COLLECTION
Authors: Afnita Dwi , Helmiah Fauriatun , Rahmadani Nurul
Published: May 2023

Abstact : Kaka Collection is a business engaged in the business of selling various kinds of fashion products such as, children's clothing, women's clothing, adult pants, men's pants. In maintaining a more advanced competitiveness, the company must continue to develop technology, another thing that needs to be considered in making the company more advanced is the relationship with customers which is also an important thing to always maintain. In an effort to manage good relationships with potential customers and customers, companies use Customer Relationship Management (CRM). CRM is a service to customers that is personal, with the aim of providing consistent experience, so as to provide customer satisfaction, and also get good relationships in the long term. By implementing a good E-CRM, companies will find it easier to interact with potential customers and customers and provide information according to their needs. Customers can also get the information they need more quickly and easily. By implementing Customer Relationship Management (CRM) carried out by Kaka Collection as an effort to increase customer loyalty, it has been well proven by the attack of the process above and with the existence of this application to increase repurchases from total sales every month. Keywords: Customer Relationship Management (CRM); Penjualan; Pelanggan  Abstrak : Kaka Collection adalah usaha yang bergerak di bidang usaha penjualan berbagai macam produk fashion seperti, pakaian anak, pakaian wanita, celana dewasa, celana laki-laki. Dalam mempertahankan daya saing yang lebih maju, maka perusahaan harus terus mengembangkan teknologi, hal lain yang perlu diperhatikan dalam membuat perusahaan lebih maju adalah relasi dengan para pelanggan yang juga merupakan hal penting untuk selalu dijaga. Dalam upaya pengelolaan hubungan yang baik dengan calon pelanggan maupun pelanggan, perusahaan menggunakan Customer Relationship Management (CRM). CRM merupakan suatu pelayanan terhadap pelanggan yang bersifat personal, dengan bertujuan memberi pengalamaan yang konsisten, sehingga dapat memberikan kepuasan pelanggan, dan juga mendapatkan relasi yang baik dalam jangka waktu panjang. Dengan menerapkan E-CRM yang baik, perusahaan akan lebih mudah berinteraksi dengan calon pelanggan maupun pelanggan dan menyediakan informasi sesuai dengan kebutuhannya. Pelanggan juga dapat memperoleh informasi yang dibutuhkan dengan lebih cepat dan mudah. Dengan menerapkan Customer Relationship Management (CRM) yang dilakukan Kaka Collection sebagai upaya untuk meningkatkan loyalitas pelanggan sudah baik dibuktikan dengan serangakaian proses diatas dan dengan adanya aplikasi ini untuk meningkatnya pembelian kembali dari total penjualan setiap bulan Kata Kunci : Customer Relationship Management (CRM); Penjualan; Pelanggan.
Analisa Tingkat Keberhasilan Inseminasi Buatan (IB) Berdasarkan Conception Rate (Cr) Pada Ternak Sapi Betina Potong Produktif Di Kecamatan Tarano Kabupaten Sumbawa NTB
Authors: Kuswanto Adi , Ningtyas Novarina Sulsia Ista'In , Tirtasari Kunti
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh tingkat keberhasilan inseminasi buatan (IB) terhadap peningkatan populasi Sapi potong di Kecamatan Tarano Kabupaten Sumbawa berdasarkan Conseption Rate (CR). Jenis penelitian ini adalah penelitian deskriptif kuantitatif dengan mengambil data di lapangan dan menganalisisnya menggunkan rumus, Conception Rate (CR) untuk ditarik kesimpulan. Populasi Sapi potong produktif dalam penelitian adalah 3,504. Sampel yang digunakan sebanyak 50 sampel dan sampel diambil pada bulan Januari dan Februari 2020. Hasil penelitian ini menunjukkan bahwa tingkat keberhasilan Inseminasi Buatan berdasarkan Conception Rate (CR) berada di atas rata-rata tingkat keberhasilan inseminasi pada umumnya yaitu 60 -70%, nilai tersebut sudah menunjukkan angka yang cukup baik untuk wilayah Kecamatan Tarano, Kabupaten Subawa. Faktor-faktor yang mempengaruhi keberhasilan IB adalah waktu pelaksanaan IB dan keterampilan breeder dalam mendeteksi birahi.
Is Accreditation of Prior Experiential Learning a familiar or unfamiliar process for Academics and Policymakers?
Authors: Kasola Sofia , Karalis Thanassis
Published: May 2023

The article analyses the awareness of accreditation of prior experimental learning at European level. The research was conducted in 4 countries, namely Denmark, Greece, Iceland, and Italy. The choice of the specific countries was not random but based on/originated from the different cultures in North and South Europe and also different approaches to adult education. The target group was academics with experience in teaching in higher education and policymakers in the field of Education and in adult education. Also, the target group members were qualified for such procedures (whether the results refer to) either for the labour market or the education sector. The feedback was recorded through interviews of 68 academics and policymakers in the four countries. The current research focuses on the accreditation of prior experiential learning for entering higher education using a different path than the traditional one established in each country. The aim of this research is to establish/suggest another step/way to record the current situation in a European context and to contribute to further development and motivation. From the results, we can conclude that the information and awareness of the issue among both academics and policymakers is not in the same level in the four countries where the survey was carried out.
KEJAHATAN SEKSUAL DAN HUKUM ISLAM
Authors: Thorik Achmad , Nida Maula
Published: May 2023

Sexual crimes have many types and terms.  In addition, cultural differences can create different perceptions of sexual crimes.  This article discusses how western views and Islamic views detail the types of sexual crimes.  This study uses a philosophical normative approach, comparative analysis method, and qualitative research methods of literature in fiqh and zawajir books.  Then the results are compared with various types of sexual crimes in Western terms. Through it, the meeting points and differences between the two views made clear and solutions to understanding unwritten Islamic law.  It is important for adherents of these two views to understand each other before having a dialogue on deeper themes.

Keywords: Sexual crimes; Islamic law; western law
PENERAPAN HUKUM TERHADAP ANAK YANG MELAKUKAN ABORTUS DIKAITKAN DENGAN PASAL 49 AYAT 2 KUHP.
Authors: Asmarawati Tina
Published: May 2023

Today there is a lot of sexual violence against minors. A religious teacher as well as a scout and paskibraka trainer at SMPN Tangerang molested his students and the victim received trauma healing services for his psychic healing. If a child commits a crime, it is regulated under Law Number 11 of 2012 concerning the Juvenile Justice System. Imprisonment for children is only used as a last resort (ultimum remedium). The issue of abortion is regulated in Article 346 of the Criminal Code, namely that a woman intentionally causes the abortion or death of her womb or orders someone else to cause the perpetrator to be sentenced to a maximum imprisonment of four years divided by two. The author considers it important to examine this issue because children are the younger generation who must receive special protection. Problem Formulation How is the application of the law to children who have abortions? Can the crime of abortion committed by children be categorized into Article 49 paragraph 2 of the Criminal Code. Objectives and Uses of Theoretical Research is expected to provide benefits and expand thinking on the development of legal science in the field of Criminal Law, especially in the crime of abortion due to rape. The method that the author uses in this research is normative juridical. In conclusion, children who have an abortion due to rape can be categorized into article 49 paragraph 2 of the Criminal Code. (noodweer exces) into forgiving reasons (fait d'axcuse) because it eliminates the element of guilt of the criminal offender.

Keywords: Rape; child; abortion
PEMBAGIAN WARIS TERHADAP PASANGAN MUSLIM YANG MEMILIKI PERJANJIAN PRA NIKAH
Authors: Zabar Khobir Abdul , Zubaedah Rahmi
Published: May 2023

Heirs are entitled to the possessions or relics of the deceased, and the division of the inheritance can mean the property to be Shared with the bereaved, and then the prenup is a covenant couples make in order to make a provision or something in their household. The writing USES normative legal research methods through literature studies. The study explains that, while the marriage covenant has been made, it cannot put off the liabilities of one another, especially in the division of the property, which, although there isa wealth separating agreement, only separates the congenital items, for the possessions obtained during the marriage, when one dies, the share of the heir to the marriage will go in accordance with the islamic scriptures.

Key Words; Prenupial Agreements; Heirs; Islamic Law
TRADISI TUJUH BULANAN DALAM PERSPEKTIF HUKUM ISLAM DAN HUKUM ADAT ( Studi Kasus Di Desa Pohsangit Lor Kecamatan Wonomerto Kabupaten Probolinggo )
Authors: Hadi Samsul , Tuqo Romadhan Moh. Lubsi , Fida Imanudin Abil
Published: May 2023

The research conducted by the author is to find out the law of carrying out the Seven Monthly Bathing Tradition according to the views of Islamic law and customary law in Pohsangit Lor Village, Wonomerto District, Probolinggo Regency. This type of field research is the type of research that the author does accompanied by the use of descriptive qualitative research methods with a Phenomenological approach. Because this research leads to the form of phenomena that exist in society, the results of this research will be in the form of descriptive written or spoken words from living people and behavior available in various ways to interpret experiences through interactions with others. The results of the data obtained by the author are sourced from books, articles, journals and from the results of interviews that the author has conducted including with local community leaders, one of the elders in the village, traditional birth attendants and local residents. The results of the study state that the implementation of the Seven Monthly Bathing Tradition does not contain elements of shirk in it because the ceremony carried out today has occurred religious acculturation so that it contains many values of benefit for people who carry it out. Therefore, some scholars made a fatwa that the tradition is permissible, meaning that it is permissible if the community wants to carry it out but there is no obligation in it. Meanwhile, according to customary law, the implementation of the Seven Monthly Bathing Tradition has a mandatory nature in it because it is to maintain the preservation of customs and also pamali according to one of the elders there if they leave the tradition.

Keywords: Seven Monthly Bathing Tradition, Islamic Law, Customary Law.
IMPACT OF INDONESIA GOVERMENT POLICY IN PP NO. 27 OF 2021 CONCERNING THE IMPLEMENTATION OF THE MARINE AND FISHERIES SECTOR
Authors: Rohani Aceng Asnawi , Fasyehhudin Mohamad , Mega Jaya Belardo Prasetya
Published: May 2023

Government Regulation Number 27 of 2021 concerning the implementation of fisheries and marine affairs is one of the results of discussions to realize a national strategic plan for Indonesia in fisheries and marine affairs. However, in its implementation, it turns out that there are pros and cons in the community. The objective of this research is to analyze the impact of the enactment of Government Regulation Number 27 of 2021 concerning the implementation of the Marine Affairs and Fisheries Sector in realizing the national strategic plan in the marine and fisheries sector by comparing two sides between the government and the community. The results of this research indicate that there are differences of opinion from the Government side which states that Government Regulation Number 27 of 2021 concerning the Implementation of the Fisheries and Marine Affairs has a positive impact on marine and fisheries aspects in Indonesia. Nevertheless, from the community side, it states that there is a negative impact for the benefit and welfare of the people on environmental sustainability.

 Keywords: Fisheries and Marine; Indonesia Government Policy; National Strategic Plan; Polivy impact.
JURIDICAL REVIEW OF THE WINNING OF THE EMPTY BOXES IN REGIONAL HEAD ELECTIONS
Authors: Fadhlillah Muhammad Rizqi , Yusuf Yusmedi , Indayatun Ratna , Safri Hasan Hamid
Published: May 2023

Elections for Regional Heads or commonly known as “Pilkada” are carried out directly by residents of the local administrative area who meet the requirements. The election of regional heads is carried out in a package together with the deputy regional heads. The regional heads and deputy regional heads in question include the governor and deputy governor for the province, the mayor and the deputy mayor for the city, and the regent and deputy regent for the district. Regarding the elections, By law, winning the empty box is allowed based on Article 54 D (2) of Law Number 10 of 2016 concerning the Second Amendment to Law Number 1 of 2015 concerning Stipulation of Government Regulations in Lieu of Law Number 1 of 2014 concerning Election of Governors, Regents , and the Mayor becomes Law. However, the next question is that the official appointed by the government based on the winner of the empty box represents legal interests. This has not been regulated by the government, so it is necessary to revise the latest Law to find out about it.

Keywords: Election, Regional Head, Empty Box
OLEKSANDRA KULISH’S MEMORIES OF TARAS SHEVCHENKO: ISSUES OF AUTHENTICITY
Authors: Nazarenko Mykhailo
Published: May 2023

The paper deals with the set of memoir texts of Oleksandra Kulish (Hanna Barvinok), i. e. essays, notes, and excerpts from correspondence concerning her communication with Shevchenko. Since Kulish’s memoirs have not been annotated yet, one of the current tasks of Shevchenko studies is to establish the degree of reliability of the memoirist’s statements, made decades after the described events. Kulish’s memories of Shevchenko are naturally divided into two groups according to the chronology of the events presented: the wedding in 1847 and her stay in St. Petersburg during 1859—1861. Most of the memoirist’s testimony regarding Shevchenko’s stay in Motronivka as the best man at the wedding is confirmed by other sources; some statements are quite probable, but it is impossible to verify them (for example, that Shevchenko arrived three days before the wedding). However, many statements contradict other memoirs: for instance, Panteleimon Kulish reported differently about how he invited Shevchenko to the wedding and how he and Olexandra planned his trip to Western Europe. As a result, researchers can only hypothetically reconstruct the events. This is complicated by the fact that Oleksandra Kulish often downplayed her role (for example, she very rarely mentioned that she had wanted to give her dowry for Shevchenko’s stay in Europe) in order to magnify the figure of her husband. Even more problematic are Kulish’s memories of Shevchenko’s life in St. Petersburg in the last years of his life. Kulish’s texts can combine facts confirmed by other sources, unique but plausible information and (un)obvious errors in an unpredictable way. Often, senile memory failed the memoirist, and she described the events of different years or even decades as synchronous. A significant part of her statements comes from the works of Panteleimon Kulish, his memoirs or letters. The everyday details presented by the memoirist seem to be the most authentic, as they are not related to either polemical or apologetic goals of the memoirs.
A Brief Note on the Doctrine of Police Operational Independence
Authors: Shiels Robert S.
Published: May 2023

A recent study in this journal of the doctrine of police operational independence has raised important questions around that concept ( Malik, 2022 ). New boundaries of tolerance and influence, it is said, need to be negotiated for the Scottish Police Authority to be able to play a more meaningful and independent oversight role in police governance. Yet, in that recent study an essential aspect of the law of Scotland was overlooked as an important component in assessing the doctrine of police operational independence.
Winston Churchill in a Christie Mystery
Authors: Dudley Edwards Owen
Published: May 2023

This essay looks at the literary relationship between two of Britain’s great twentieth century figures, Agatha Christie and Winston Churchill. The two are rarely considered together, but did Christie, in ‘The Augean Stables’ (1940), cast Churchill as the warmonger Everhard?
Det frivilliga fältets geografi: En forskningsöversikt över det frivilliga fältets förutsättningar för samverkan inom räddning och respons
Authors: Stenberg Rebecca
Published: May 2023

Det finns ett ökande intresse från blåljusaktörer som kommunal räddningstjänst och statlig sjö- och flygräddning samt polisen och, att samverka med frivilliga privata personer, grupper och organisationer. Det finns också ett ökande intresse från medborgare att bidra för trygghet, räddning och säkerhet. Fältet ”frivilliga verksamheter” består av en mängd olika verksamheter som på många sätt är väsensskilda, med mycket olika målgrupper, medlemmar, inriktning, kunskaper och etableringsgrad. När systematisk samverkan och utbyte mellan myndigheter/offentliga verksamheter och frivilliga verksamheter planeras är kunskapen om frivilligverksamhetens förutsättningar viktig. Inom ramen för projektet ”Frivillighetens geografi” är syftet med denna forskningsöversikt att identifiera dimensioner som kan beskriva mångfalden av frivilliga aktörer och verksamheter och som är av betydelse för räddningssamverkan och lämpliga samverkansformer mellan räddningsaktörer och frivilliga.Metoder som används för litteraturöversikten var riktade sökningar samt sökningar i Unisearch, SafeLit och Scopus efter olika aspekter av frivillighet och frivilliga inom räddning med sökorden volunteers AND citizens AND rescue OR Rescue Service AND collaboration OR co-production OR co-operation. Sammantaget gav det 41 publikationer som analyserades med riktad innehållsanalys till teman. I resultatet kunde tio olika typer av frivilliga identifieras när det gäller räddning och respons från väl inarbetade och organiserade frivilliga försvarsorganisationer till åskådare, CSR-verksamheter och exploatörer. Frånsett sist nämnda, kan de bidra inom olika områden som ställer olika krav på kunskaper och förmåga. Samverkan med frivilliga kan också inrättas olika utifrån vilka behov av kontroll eller behov av initiativ och egenutveckling som finns. Tidsperspektiv på när frivilligas bidrag gör mest nytta bör beaktas. Idag saknas i Sverige i stort sett frivilliginsatser inom förebyggande eller analys. Utöver tidsfaktorn har åtta olika dimensioner som har betydelse för den frivilliga verksamhetens möjligheter att samverka och bidra inom räddning och respons identifierats. Dessa sträcker sig från graden av inriktning mot räddning och integration i räddningssystemet till legitimitet och vilka resurser man förfogar över eller geografisk täckningsgrad. Slutsatsen är att kombinationerna av dimensioner till den frivilliga verksamhetens karaktär och särart avgör var och hur verksamheten kan bidra i en mångfald av olika möjligheter från grannsamverkan till första respons eller organisering av beredskap. Möjligheterna till samverkan med frivilliga avgörs snarare av räddningssystemets förmåga att kanalisera, hantera och ta vara på mångfalden. Frågor att ta ställning till och ett förslag till checklista utifrån slutsatserna bifogas.
¿Categoría De Capacidad Aeróbica? O ¿Categoría De Sistemas Energéticos?
Authors: Rincón Castillo Emerson Julian , Fernández Millan Karem Elizabeth , Tocora Guzmán Maria de los Angeles , Bulla Casas Andrés Felipe , López Ospina Erika Xiomara , Riscanevo Rodríguez Kimberly Lizeth
Published: May 2023

Introducción: La guía para la práctica de la fisioterapia desarrollada por la Asociación Americana de Terapia Física, propone evaluar ciertas categorías que podrían afectar el movimiento corporal humano. Dentro de estas categorías, se encuentra la categoría de capacidad aeróbica, la cual evalúa la capacidad de producción de energía a partir de la oxidación del oxígeno, categoría que olvida los procesos energéticos metabólicos donde no se necesita de la oxidación del oxígeno para la producción de energía. Objetivo: Reflexionar sobre la categoría de capacidad aeróbica propuesta por APTA y proponer la categoría de sistemas energéticos, como categoría integral para la valoración del metabolismo celular. Metodología: Para esta reflexión se seleccionó un enfoque de investigación cualitativa, y con el fin de fundamentar la reflexión, se buscó artículos con temáticas relacionadas con fisiología del ejercicio, sistemas energéticos, metabolismo aeróbico y anaeróbico, al igual que pruebas de evaluación anaeróbica y aeróbica, se eligieron los artículos con el aporte pertinente con el objeto de estudio y se procedió a realizar la reflexión respectiva. Conclusiones: Por si sola, la categoría de capacidad aeróbica propuesta en la guía APTA, deja la evaluación y el análisis del metabolismo celular inconclusa. La categoría de sistemas energéticos propuesta con sus dos componentes, aeróbico y anaeróbico, es la mejor manera para que los docentes, estudiantes y profesionales en fisioterapia puedan evaluar, diagnosticar, pronosticar, e intervenir con mayor claridad el paciente/usuario, con resultados más directos sobre el metabolismo celular.
Role of serotype and virulence determinants of Streptococcus pyogenes biofilm bacteria in internalization and persistence in epithelial cells in vitro
Authors: Alamiri Feiruz , André Oscar , De Supradipta , Nordenfelt Pontus , Hakansson Anders P.
Published: May 2023

Streptococcus pyogenes causes a multitude of local and systemic infections, the most common being pharyngitis in children. Recurrent pharyngeal infections are common and are thought to be due to the re-emergence of intracellular GAS upon completion of antibiotic treatment. The role of colonizing biofilm bacteria in this process is not fully clear. Here, live respiratory epithelial cells were inoculated with broth-grown or biofilm bacteria of different M-types, as well as with isogenic mutants lacking common virulence factors. All M-types tested adhered to and were internalized into epithelial cells. Interestingly, internalization and persistence of planktonic bacteria varied significantly between strains, whereas biofilm bacteria were internalized in similar and higher numbers, and all strains persisted beyond 44 hours, showing a more homogenous phenotype. The M3 protein, but not the M1 or M5 proteins, was required for optimal uptake and persistence of both planktonic and biofilm bacteria inside cells. Moreover, the high expression of capsule and SLO inhibited cellular uptake and capsule expression was required for intracellular survival. Streptolysin S was required for optimal uptake and persistence of M3 planktonic bacteria, whereas SpeB improved intracellular survival of biofilm bacteria. Microscopy of internalized bacteria showed that planktonic bacteria were internalized in lower numbers as individual or small clumps of bacteria in the cytoplasm, whereas GAS biofilm bacteria displayed a pattern of perinuclear localization of bacterial aggregates that affected actin structure. Using inhibitors targeting cellular uptake pathways, we confirmed that planktonic GAS mainly uses a clathrin-mediated uptake pathway that also required actin and dynamin. Clathrin was not involved in biofilm internalization, but internalization required actin rearrangement and PI3 kinase activity, possibly suggesting macropinocytosis. Together these results provide a better understanding of the potential mechanisms of uptake and survival of various phenotypes of GAS bacteria relevant for colonization and recurrent infection.
Development and validation of a scoring system for the prediction of HIV drug resistance in Hubei province, China
Authors: Yan Jisong , Zhang Wenyuan , Luo Hong , Wang Xianguang , Ruan Lianguo
Published: May 2023

Objective

The present study aimed to build and validate a new nomogram-based scoring system for the prediction of HIV drug resistance (HIVDR).

Design and methods

Totally 618 patients with HIV/AIDS were included. The predictive model was created using a retrospective set (N = 427) and internally validated with the remaining cases (N = 191). Multivariable logistic regression analysis was carried out to fit a model using candidate variables selected by Least absolute shrinkage and selection operator (LASSO) regression. The predictive model was first presented as a nomogram, then transformed into a simple and convenient scoring system and tested in the internal validation set.

Results

The developed scoring system consisted of age (2 points), duration of ART (5 points), treatment adherence (4 points), CD4 T cells (1 point) and HIV viral load (1 point). With a cutoff value of 7.5 points, the AUC, sensitivity, specificity, PLR and NLR values were 0.812, 82.13%, 64.55%, 2.32 and 0.28, respectively, in the training set. The novel scoring system exhibited a favorable diagnostic performance in both the training and validation sets.

Conclusion

The novel scoring system can be used for individualized prediction of HIVDR patients. It has satisfactory accuracy and good calibration, which is beneficial for clinical practice.
Current status of transcatheter mitral valve replacement: systematic review and meta-analysis
Authors: Alperi Alberto , Avanzas Pablo , Leon Victor , Silva Iria , Hernández-Vaquero Daniel , Almendárez Marcel , Álvarez Rut , Fernández Félix , Moris Cesar , Pascual Isaac
Published: May 2023

Introduction

Mitral Regurgitation (MR) has a strong impact on quality of life and on mid-term survival. Transcatheter mitral valve replacement (TMVR) is rapidly expanding and a growing number of studies have been published recently.

Methods

A systematic review of studies reporting on clinical data for patients with symptomatic severe MR undergoing TMVR was performed. Early- and mid-term outcomes (clinical and echocardiographic) were evaluated. Overall weighted means and rates were calculated. Risk ratios or mean differences were calculated for pre- and post-procedural comparisons.

Results

A total of 12 studies and 347 patients who underwent TMVR with devices clinically available or under clinical evaluation were included. Thirty-day mortality, stroke and major bleeding rates were 8.4%, 2.6%, and 15.6%, respectively. Pooled random-effects demonstrated a significant reduction of ≥ grade 3+ MR (RR: 0.05; 95% CI: 0.02–0.11; p < 0.001) and in the rates of patients in NYHA class 3–4 after the intervention (RR: 0.27; 95% CI: 0.22–0.34; p < 0.001). Additionally, the pooled fixed-effect mean difference for quality of life based on the KCCQ score yielded an improvement in 12.9 points (95% CI:7.4–18.4, p < 0.001), and exercise capacity improved by a pooled fixed-effect mean difference of 56.8 meters in the 6-minute walk test (95% CI 32.2–81.3, p < 0.001).

Conclusions

Among 12 studies and 347 patients comprising the updated evidence with current TMVR systems there was a statistically significant reduction in ≥ grade 3+ MR and in the number of patients exhibiting poor functional class (NYHA 3 or 4) after the intervention. Overall rate of major bleeding was the main shortcoming of this technique.
The effect of postoperative anticoagulation on acute aortic dissection: a systematic review and meta-analysis
Authors: Gong Xiangfeng , Lang Qianlei , Qin Chaoyi , Meng Wei , Xiao Zhenghua
Published: May 2023

Background and aim

The evolution of the false lumen after the repair of acute aortic dissection has been linked to numerous adverse clinical outcomes, including increased late mortality and a higher risk of reoperation. Despite the widespread use of chronic anticoagulation in patients who have undergone repair for acute aortic dissection, the effects of this therapy on false lumen evolution and its subsequent consequences are yet to be fully understood. This meta-analysis aimed to investigate the impact of postoperative anticoagulation on patients with acute aortic dissection.

Methods

In PubMed, Cochrane Libraries, Embase, and Web of Science, we performed a systematic review of nonrandomized studies, comparing outcomes with postoperative anticoagulation vs. non-anticoagulation on aortic dissection. We investigated the status of false lumen (FL), aorta-related death, aortic reintervention, and perioperative stroke in aortic dissection patients with anticoagulation and non-anticoagulation.

Results

After screening 527 articles, seven non-randomized studies were selected, including a total of 2,122 patients with aortic dissection. Out of these patients, 496 received postoperative anticoagulation while 1,626 served as controls. Meta-analyses of 7 studies revealed significantly higher FL patency in Stanford type A aortic dissection (TAAD) postoperative anticoagulation with an OR of 1.82 (95% CI: 1.22 to 2.71; Z = 2.95; I²=0%; P = 0.93). Moreover, there was no statistically significant difference between the two groups in aorta-related death, aortic reintervention, and perioperative stroke with an OR of 1.31 (95% CI: 0.56 to 3.04; Z = 0.62; I² = 0%; P = 0.40), 0.98 (95% CI: 0.66 to 1.47; Z = 0.09; I² = 23%; P = 0.26), 1.73 (95% CI: 0.48 to 6.31; Z = 0.83; I² = 8%; P = 0.35), respectively.

Conclusions

Postoperative anticoagulation was associated with higher FL patency in Stanford type A aortic dissection patients. However, there was no significant difference between the anticoagulation and non-anticoagulation groups in terms of aorta-related death, aortic reintervention, and perioperative stroke.
Winter and summer sedimentary dynamic process observations in the sea area off Qinhuangdao in the Bohai Sea, China
Authors: Zhang Deqiang , Pang Chongguang , Liu Zhiliang , Jiang Jingbo
Published: May 2023

Sedimentary processes in marginal seas play an important role in the biology, physics, and geochemistry as well as ecology of coastal environments and contain abundant information about the material transfer from land to ocean and the regional circulation. Due to the huge sediment discharge of the Yellow River, the Bohai Sea, China is one of the areas with the highest suspended sediment concentration (SSC) in the world. Interestingly, the SSC at the west of the Bohai Sea is low all year round. Thus, it is of great significance to examine the sedimentary dynamic process in this area for better understanding the circulation structure, material exchange and regional environment of the Bohai Sea. Using seabed base observation platform measurements obtained in February 2017 and August 2019, this study examines the winter and summer hydrography and suspended sediment concentration in the sea area off Qinhuangdao located to the west of the Bohai Sea. In summer, the relatively weak residual currents flowed northeastward and showed little correlation with the wind field, especially in the middle layer of the water column. In winter, the residual currents were strengthened, flowing to the northeast during strong wind periods, and predominantly to the southwest during intermittent periods. Moreover, driven by the pressure gradient force associated with the wind-induced sea surface height variations, the winter current was closely related to the wind speed, with correlation coefficients ranging from 0.4 to 0.6 and a time lag of 10 h. The summer SSC was lower and mainly controlled by the tidal current, whereas in winter, owing to the enhanced Reynolds stress and turbulent kinetic energy, strong wind bursts triggered significant sediment resuspension and led to a higher SSC. For the suspended sediment flux (SSF), the advection terms contributed more than 80% in the winter and summer, while the vertical circulation terms contributed 13% in winter, and approximately half that much in summer. Generally, the suspended sediment is transported back and forth, with a little net northward and northeastward motions in winter and summer, respectively. This may explain the low SSC sustaining in coastal Qinhuangdao all year round. These results provide a reference for sedimentary studies conducted in other coastal waters, especially in monsoon-dominating shelf seas.
Co-creating tools to monitor first graders’ progress in reading: a balancing act between perceived usefulness, flexibility, and workload
Authors: Francotte Eve , Colognesi Stéphane , Coertjens Liesje
Published: May 2023

Introduction

Educational inequalities – i.e., the achievement gaps between pupils from disadvantaged backgrounds and their peers from advantaged backgrounds – are present in many OECD countries. This is particularly problematic in reading, which is a predictor of future academic and social success. To reduce this reading achievement gap, recent meta-analyses point toward progress monitoring: regularly measuring pupils’ mastery levels and differentiating instruction accordingly. However, the research recommendations only slowly make their way to teaching habits, particularly because teachers may consider progress monitoring difficult and cumbersome to implement. To avoid such difficulties, partnerships between teachers and researchers have been recommended. These allow teachers’ complex realities to be taken into account and, consequently, tools to be designed that are meaningful and feasible for practitioners.

Method

Using an iterative and participatory process inspired by practice-embedded research, the present research set out to (1) co-construct tools to monitor first-graders’ progress in reading, and (2) examine how these tools met teachers’ needs. Five teachers in the French-speaking part of Belgium co-constructed four tools during four focus groups. The transcribed discussions were analyzed using an interactional framework containing three areas of knowledge: shared, accepted, and disputed.

Results and Discussion

The results indicated three shared needs: perceived usefulness, flexibility of the tools, and a desire to limit the workload. In addition, teachers accepted that, between them, needs varied regarding the goal for progress monitoring and the format of the evaluation. They had lengthy discussions on balancing workload and perceived utility, leading them to conclude that there were two groups of teachers. The first group questioned the added value of the progress monitoring tools in relation to their habitual practice. The second group on the other hand described the added value for the teacher, certainly when aiming to grasp the level and difficulties of struggling pupils. This second group had fewer years of teaching experience and described their classroom practice as less organized compared to the teachers from the first group. Theoretical and practical implications of these findings are discussed below.
Case Report: short stature, kidney anomalies, and cerebral aneurysms in a novel homozygous mutation in the PCNT gene associated with microcephalic osteodysplastic primordial dwarfism type II
Authors: Petraroli Maddalena , Percesepe Antonio , Piane Maria , Ormitti Francesca , Castellone Eleonora , Gnocchi Margherita , Messina Giulia , Bernardi Luca , Patianna Viviana Dora , Esposito Susanna Maria Roberta , Street Maria Elisabeth
Published: May 2023

We report the case of a boy (aged 3 years and 7 months) with severe growth failure (length: -9.53 SDS; weight: -9.36 SDS), microcephaly, intellectual disability, distinctive craniofacial features, multiple skeletal anomalies, micropenis, cryptorchidism, generalized hypotonia, and tendon retraction. Abdominal US showed bilateral increased echogenicity of the kidneys, with poor corticomedullary differentiation, and a slightly enlarged liver with diffuse irregular echotexture. Initial MRI of the brain, performed at presentation, showed areas of gliosis with encephalomalacia and diffused hypo/delayed myelination, and a thinned appearance of the middle and anterior cerebral arteries. Genetic analysis evidenced a novel homozygous pathogenic variant of the pericentrin (PCNT) gene. PCNT is a structural protein expressed in the centrosome that plays a role in anchoring of protein complexes, regulation of the mitotic cycle, and cell proliferation. Loss-of-function variants of this gene are responsible for microcephalic osteodysplastic primordial dwarfism type II (MOPDII), a rare inherited autosomal recessive disorder. The boy died at 8 years of age as a result of an intracranial hemorrhage due to a cerebral aneurism associated with the Moyamoya malformation. In confirmation of previously published results, intracranial anomalies and kidney findings were evidenced very early in life. For this reason, we suggest including MRI of the brain with angiography as soon as possible after diagnosis in follow-up of MODPII, in order to identify and prevent complications related to vascular anomalies and multiorgan failure.