bluuebunny/crossref_metadata_2025 huggingface dataset:
Interaction of Thymine DNA Glycosylase with Oxidised 5-Methyl-cytosines in Their Amino- and Imino-Forms
Authors: Volkenandt Senta , Beierlein Frank , Imhof Petra
Published: September 2021

Thymine DNA Glycosylase (TDG) is an enzyme of the base excision repair mechanism and removes damaged or mispaired bases from DNA via hydrolysis of the glycosidic bond. Specificity is of high importance for such a glycosylase, so as to avoid the damage of intact DNA. Among the substrates reported for TDG are mispaired uracil and thymine but also formyl-cytosine and carboxyl-cytosine. Methyl-cytosine and hydroxylmethyl-cytosine are, in contrast, not processed by the TDG enzyme. We have in this work employed molecular dynamics simulations to explore the conformational dynamics of DNA carrying a formyl-cytosine or carboxyl-cytosine and compared those to DNA with the non-cognate bases methyl-cytosine and hydroxylmethyl-cytosine, as amino and imino tautomers. Whereas for the mispairs a wobble conformation is likely decisive for recognition, all amino tautomers of formyl-cytosine and carboxyl-cytosine exhibit the same Watson–Crick conformation, but all imino tautomers indeed form wobble pairs. The conformational dynamics of the amino tautomers in free DNA do not exhibit differences that could be exploited for recognition, and also complexation to the TDG enzyme does not induce any alteration that would indicate preferable binding to one or the other oxidised methyl-cytosine. The imino tautomers, in contrast, undergo a shift in the equilibrium between a closed and a more open, partially flipped state, towards the more open form upon complexation to the TDG enzyme. This stabilisation of the more open conformation is most pronounced for the non-cognate bases methyl-cytosine and hydroxyl-cytosine and is thus not a likely mode for recognition. Moreover, calculated binding affinities for the different forms indicate the imino forms to be less likely in the complexed DNA. These findings, together with the low probability of imino tautomers in free DNA and the indifference of the complexed amino tautomers, suggest that discrimination of the oxidised methyl-cytosines does not take place in the initial complex formation.
Dual Delivery of TGF-β3 and Ghrelin in Microsphere/Hydrogel Systems for Cartilage Regeneration
Authors: Lin Jianjing , Wang Li , Lin Jianhao , Liu Qiang
Published: September 2021

Articular cartilage (AC) damage is quite common, but due to AC’s poor self-healing ability, the damage can easily develop into osteoarthritis (OA). To solve this problem, we developed a microsphere/hydrogel system that provides two growth factors that promote cartilage repair: transforming growth factor-β3 (TGF-β3) to enhance cartilage tissue formation and ghrelin synergy TGF-β to significantly enhance the chondrogenic differentiation. The hydrogel and microspheres were characterized in vitro, and the biocompatibility of the system was verified. Double emulsion solvent extraction technology (w/o/w) is used to encapsulate TGF-β3 and ghrelin into microspheres, and these microspheres are encapsulated in a hydrogel to continuously release TGF-β3 and ghrelin. According to the chondrogenic differentiation ability of mesenchymal stem cells (MSCs) in vitro, the concentrations of the two growth factors were optimized to promote cartilage regeneration.
Elucidation of the Structure of Lignin–Carbohydrate Complexes in Ginkgo CW-DHP by 13C-2H Dual Isotope Tracer
Authors: Zhang Kai , Liu Yanchao , Cui Sheng , Xie Yimin
Published: September 2021

To elucidate the chemical linkages between lignin and carbohydrates in ginkgo cell walls, 13C-2H-enriched cell wall-dehydrogenation polymers (CW-DHP) were selectively prepared with cambial tissue from Ginkgo biloba L. by feeding D-glucose-[6-2H2], coniferin-[α-13C], and phenylalanine ammonia-lyase (PAL) inhibitor. The abundant detection of 13C and 2H confirmed that D-glucose-[6-2H2] and coniferin-[α-13C] were involved in the normal metabolism of ginkgo cambial cells that had been effectively labelled with dual isotopes. In the ginkgo CW-DHP, ketal and ether linkages were formed between the C-α of lignin side chains and carbohydrates, as revealed by solid state CP/MAS 13C-NMR differential spectroscopy. Furthermore, the DMSO/TBAH ionic liquids system was used to fractionate the ball-milled CW-DHP into three lignin-carbohydrate complex (LCC) fractions: glucan–lignin complex (GL), glucomannan–lignin complex (GML), and xylan–lignin complex (XL). The XRD determination indicated that the cellulose type I of the GL was converted into cellulose type II during the separation process. The molecular weight was in the order of Ac-GL > Ac-GML > XL. The 13C-NMR and 1H-NMR differential spectroscopy of 13C-2H-enriched GL fraction indicated that lignin was linked with cellulose C-6 by benzyl ether linkages. It was also found that there were benzyl ether linkages between the lignin side chain C-α and glucomannan C-6 in the 13C-2H-enriched GML fraction. The formation of ketal linkages between the C-α of lignin and xylan was confirmed in the 13C-2H-enriched XL fraction.
Differential Incidence of Tongue Base Cancer in Male and Female HPV16-Transgenic Mice: Role of Female Sex Hormone Receptors
Authors: de Oliveira Neto Clariano Pires , Medeiros-Fonseca Beatriz , Estêvão Diogo , Mestre Verónica F. , Costa Natália R. , de Andrade Fábio Evangelista , Oliveira Paula A. , Bastos Margarida M. S. M. , Medeiros Rui , Assis Diogo , Félix Ana , Ferreira Lopes Fernanda , Gil da Costa Rui M. , Brito Haissa O. , Brito Luciane M. O.
Published: September 2021

A growing proportion of oropharyngeal squamous cell carcinomas (OPSCC) are associated with infection by high-risk human papillomavirus (HPV). For reasons that remain largely unknown, HPV+OPSCC is significantly more common in men than in women. This study aims to determine the incidence of OPSCC in male and female HPV16-transgenic mice and to explore the role of female sex hormone receptors in the sexual predisposition for HPV+ OPSCC. The tongues of 30-weeks-old HPV16-transgenic male (n = 80) and female (n = 90) and matched wild-type male (n = 10) and female (n = 10) FVB/n mice were screened histologically for intraepithelial and invasive lesions in 2017 at the Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Portugal. Expression of estrogen receptors alpha (ERα) and beta (ERβ), progesterone receptors (PR) and matrix metalloproteinase 2 (MMP2) was studied immunohistochemically. Collagen remodeling was studied using picrosirius red. Female mice showed robust ERα and ERβ expression in intraepithelial and invasive lesions, which was accompanied by strong MMP2 expression and marked collagen remodeling. Male mice showed minimal ERα, ERβ and MMP2 expression and unaltered collagen patterns. These results confirm the association of HPV16 with tongue base cancer in both sexes. The higher cancer incidence in female versus male mice contrasts with data from OPSCC patients and is associated with enhanced ER expression via MMP2 upregulation.
Candida glabrata Antifungal Resistance and Virulence Factors, a Perfect Pathogenic Combination
Authors: Frías-De-León María Guadalupe , Hernández-Castro Rigoberto , Conde-Cuevas Esther , García-Coronel Itzel H. , Vázquez-Aceituno Víctor Alfonso , Soriano-Ursúa Marvin A. , Farfán-García Eunice D. , Ocharán-Hernández Esther , Rodríguez-Cerdeira Carmen , Arenas Roberto , Robledo-Cayetano Maura , Ramírez-Lozada Tito , Meza-Meneses Patricia , Pinto-Almazán Rodolfo , Martínez-Herrera Erick
Published: September 2021

In recent years, a progressive increase in the incidence of invasive fungal infections (IFIs) caused by Candida glabrata has been observed. The objective of this literature review was to study the epidemiology, drug resistance, and virulence factors associated with the C. glabrata complex. For this purpose, a systematic review (January 2001–February 2021) was conducted on the PubMed, Scielo, and Cochrane search engines with the following terms: “C. glabrata complex (C. glabrata sensu stricto, C. nivariensis, C. bracarensis)” associated with “pathogenicity” or “epidemiology” or “antibiotics resistance” or “virulence factors” with language restrictions of English and Spanish. One hundred and ninety-nine articles were found during the search. Various mechanisms of drug resistance to azoles, polyenes, and echinocandins were found for the C. glabrata complex, depending on the geographical region. Among the mechanisms found are the overexpression of drug transporters, gene mutations that alter thermotolerance, the generation of hypervirulence due to increased adhesion factors, and modifications in vital enzymes that produce cell wall proteins that prevent the activity of drugs designed for its inhibition. In addition, it was observed that the C. glabrata complex has virulence factors such as the production of proteases, phospholipases, and hemolysins, and the formation of biofilms that allows the complex to evade the host immune response and generate fungal resistance. Because of this, the C. glabrata complex possesses a perfect pathogenetic combination for the invasion of the immunocompromised host.
Avaliação morfométrica da profundidade do complexo forame/canal/sulco infra-orbitário (FIO/CIO/SIO)
Authors: Freitas Catarina Alipio de , Borges Isabella dos Sanches Santos , Oliveira Gabriel Fernandes de , Rodrigues Thomas dos Reis , Prosdócimi Fábio César
Published: September 2021

Introdução. O complexo forame infra-orbitário (FIO)/canal infra-orbitário (CIO)/ sulco infra-orbitário (SIO) é uma formação anatômica por onde percorre o nervo infra-orbitário (NIO), estrutura essa considerada de importância para abordagem cirúrgica do assoalho orbital em fraturas orbitais do tipo “blow out”. Objetivo. Investigar as diferenças morfométricas e a prevalência da profundidade do complexo CIO/SIO em crânios secos, e apontar a importância dessas variações na prática cirúrgica de lesões de nervos e face. Método. Utilizou-se 15 crânios adultos (30 lados), a partir dos quais foram tiradas medidas de profundidade do complexo FIO/CIO/SIO. O estudo foi realizado na Universidade Metropolitana de Santos com o auxílio de um paquímetro digital. Resultados. Observou-se pequenas variações entre as medidas de profundidade, apresentando um valor mínimo de 17,13mm e um valor máximo de 37,08mm. Sendo a média de 27,243±4,729723mm. Conclusão. O conhecimento preciso da anatomia da região infra-orbitária é essencial para uma cirurgia mais segura e eficaz de correção de fratura do assoalho de órbita, visando a preservação da visão e da estética. Dessa forma, as complicações pós-operatórias podem ser diminuídas e o melhor resultado pode ser fornecido.
Rationale and Trial Design of MesEnchymal Stem Cell Trial in Preventing Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula (MEST AVF Trial)
Authors: Piryani Ameet K. , Kilari Sreenivasulu , Takahashi Edwin , DeMartino Randall R. , Mandrekar Jay , Dietz Allan B. , Misra Sanjay
Published: September 2021

Key Points

At 1 year after placement, 60% of hemodialysis arteriovenous fistulas (AVF) will develop venous neointimal hyperplasia (VNH) and subsequent venous stenosis (VS).

Autologous adipose-derived mesenchymal stem cells may help reduce VS formation associated with hemodialysis AVF.

There are no therapies available to prevent VS formation associated with hemodialysis AVF.

Background

Hemodialysis arteriovenous fistulas (AVFs) are the preferred vascular access for patients on hemodialysis. In the Hemodialysis Fistula Maturation Study, 44% of the patients achieved unassisted maturation of their fistula without needing an intervention. Venous neointimal hyperplasia (VNH) and subsequent venous stenosis are responsible for lack of maturation. There are no therapies that can prevent VNH/VS formation. The goal of this paper is to present the background, rationale, and trial design of an innovative phase 1/2 clinical study that is investigating the safety of autologous adipose-derived mesenchymal stem cells delivered locally to the adventitia of newly created upper extremity radiocephalic (RCF) or brachiocephalic fistula (BCF).

Methods

The rationale and preclinical studies used to obtain a physician-sponsored investigational new drug trial are discussed. The trial design and end points are discussed.

Results

This is an ongoing trial that will complete this year.

Conclusion

This is a phase 1/2 single-center, randomized trial that will investigate the safety and efficacy of autologous AMSCs in promoting maturation in new upper-extremity AVFs.

Clinical Trial registration number: NCT02808208
DESIGN METHODS FOREST FOREST ROADS BASED ON GIS SYSTEM
Authors: Abramov Ya. , Kruchinin Igor
Published: September 2021

The main tasks of selecting the best option for the route of forest roads through the use of methods based on GIS systems are considered. Such roads are characterized by the use of materials capable of meeting the basic requirements on the transport-operational condition in difficult natural and climatic conditions. As is known, the cost of maintenance and construction of such roads are quite large. Forestry engineers need to predict in advance the optimal route of a forest road. For this purpose it is necessary to carry out a comprehensive analysis of the whole design area and make a decision for the passage of the route. Thus, the methodology of analysis and optimization of forest road route design on the basis of GIS systems allows to solve this problem. This study presents in detail the methodology underlying some of the key components of the model, including the specified design constraints. The methodology solves tracing problems and provides forest engineers with a powerful tool to find the greatest number of different alignment options in a short period of time. This methodology allows for the evaluation of alternatives for a forest road alignment. The aim of the research was to develop a methodology for tracing forest roads using GIS systems. The result of the work was the creation of the methodology of forest roads routing, taking into account the standards and topographic data of the area.
Web "SignificArte"
Authors: Galera Núñez María del Mar , Guichot  Muñoz Elena , de Sarlo Giulia , Vives Almansa Rosa , Duarte Piña Olga , de Frutos Domínguez Rocío , de la Casa Almeida María
Published: September 2021

SIGNIFICARTE es un grupo de trabajo que se comenzó a gestar en 2015. El nucleo está formado por las profesoras: Mar Galera-Núñez, Elena Guichot-Muñoz y Giulia De Sarlo. Su filosofía gira en torno a cómo los lenguajes artísticos pueden promover una educación con sentido. Una educación en la que los lenguajes artísticos se constituyen como fuente, medio y visibilización del conocimiento.

SignificArte parte de la idea de que la comunicación y el arte son elementos intrínsecos a todas las personas. Nuestro grupo nace precisamente de esa necesidad de comunicarnos con los demás y de explorar cómo en ese proceso, los lenguajes artísticos pueden ayudarnos a expresarnos y conocernos, a establecer relaciones satisfactorias con los demás y con nosotros mismos. En definitiva, ser más felices y dotarnos de las herramientas adecuadas que faciliten ese camino.

Las líneas-guía que articulan el grupo de trabajo son las siguientes:

Explorar distintas metodologías en las que se aborde la enseñanza de los lenguajes artísticos desde una perspectiva en la que prime la comunicación y el autoconocimiento.
Reivindicar el proceso de enseñanza-aprendizaje como un camino abierto en el que los agentes van construyendo el saber.
Conectar y colaborar con centros y educadores/as implicados en un nuevo tipo de educación que promueva un acercamiento al alumnado significativo y consciente en el que se utilicen los lenguajes artísticos como eje vertebrador.
Generar entornos de enseñanza y aprendizaje creativos donde se tengan en cuenta y se parta de las emociones.
Buscar mecanismos de desinhibición, que propicien la expresión exenta de juicios en los diferentes lenguajes artísticos.
Trabajar desde un enfoque creativo para desautomatizar rutinas de pensamiento y propiciar entornos seguros en los que prime la curiosidad, la exploración libre como elementos base del aprendizaje.
AWARENESS, KNOWLEDGE, ATTITUDE, AND PRACTICES TOWARDS SEXUAL AND REPRODUCTIVE HEALTH AMONG SECONDARY SCHOOL STUDENTS IN MALAYSIA
Authors: Zulkarnain Abdul Rahman , Fariduddin Muhamad Nur , Ching Sin Siau
Published: September 2021

Sexual and reproductive health matters are still taboo because it is sensitive to be discussed publicly as it opposed the norms of Malaysian people, especially among high school students. This study sought to investigate the awareness, knowledge, attitudes, and practices towards sexual and reproductive health among high school students between the ages of 13 to 17 years old in Petaling Perdana district in Selangor, Malaysia. A cross-sectional survey study was conducted among 382 secondary school students using a self-administered validated questionnaire. Descriptive and MANOVA analyses were used to analyse the data. The results showed that the level of awareness, knowledge, attitude, and practices towards sexual and reproductive health was high among all secondary school students. The MANOVA analysis yielded significant differences towards practices on gender F (1, 380) = 16.035, p < .001, with males (M = 1.051) scoring higher than females (M = .661), and level of education F (4, 377) = 7.202, p < .001, with Form 5 students (M = 1.172) having the highest score. The study concluded that males had better sexual practices than females and students with a higher level of education have better understanding and practices towards their sexual and reproductive health.
Problem with data on the characteristics for a loaded system of hyperbolic equations
Authors: Assanova A.T. , Zholamankyzy A.
Published: September 2021

We consider a problem with data on the characteristics for a loaded system of hyperbolic equations of the second order on a rectangular domain. The questions of the existence and uniqueness of the classical solution of the considered problem, as well as the continuity dependence of the solution on the initial data, are investigated. We propose a new approach to solving the problem with data on the characteristics for the loaded system of hyperbolic equations second order based on the introduction new functions. By introducing new unknown functions the problem is reduced to an equivalent family of Cauchy problems for a loaded system of differential with a parameters and integral relations. An algorithm for finding an approximate solution to the equivalent problem is proposed and its convergence is proved. Conditions for the unique solvability of the problem with data on the characteristics for the loaded system of hyperbolic equations of the second order are established in the terms of coefficient's system.
On the structure of the singular set of solutions in one class of 3D time-optimal control problems
Authors: Uspenskii A.A. , Lebedev P.D.
Published: September 2021

A class of time-optimal control problems in terms of speed in three-dimensional space with a spherical velocity vector is considered. A smooth regular curve $\Gamma$ was chosen as the target set. Pseudo-vertices — characteristic points on $\Gamma,$ responsible for the appearance of a singularity in the optimal result function, are selected. The characteristic features of the structure of a singular set belonging to the family of bisectors are revealed. An analytical representation is found for the extreme points of the bisector corresponding to a fixed pseudo-vertex. As an illustration of the effectiveness of the developed methods for solving nonsmooth dynamic problems, an example of the numerical-analytical construction of resolving structures of a control problem in terms of speed is given.
Hubungan intervensi gizi spesifik dalam program gerakan 1000 HPK terhadap kejadian stunting pada baduta di wilayah kerja Puskesmas Jatiluhur Purwakarta
Authors: Efendi Nadya Fauziyah , Sitoayu Laras , Nuzrina Rachmanida , Dewanti Lintang Purwara , Wahyuni Yulia
Published: September 2021

Latar Belakang: Stunting merupakan gambaran kurangnya status gizi yang bersifat kronik pada masa pertumbuhan dan perkembangan sejak awal kehidupan. Prevalensi stunting di Indonesia tahun 2018 sebesar 30,8%, sedangkan di Puskesmas Jatiluhur prevalensi stunting tahun 2018 sebesar 9,4%. Tujuan: Mengetahui hubungan antara intervensi gizi spesifik dalam program gerakan 1000 HPK terhadap kejadian stunting di wilayah kerja Puskesmas Jatiluhur Purwakarta. Metode: Penelitian ini menggunakan desain penelitian cross sectional dengan pendekatan observasional (pengamatan) dan wawancara. Sampel penelitian ini yaitu 82 baduta usia 6–23 bulan. Uji statistik menggunakan uji Chi Square. Hasil: Hasil penelitian ini diperoleh baduta dengan jenis kelamin laki-laki (61%) dan perempuan (39%). Terdapat baduta stunting (46,3%), baduta yang diberikan ASI eksklusif (37,8%), baduta yang mendapatkan MP ASI tepat (41,5%), baduta yang menonsumsi kapsul vitamin A (72%), dan baduta yang lengkap imunisasi dasar (43,9%). Hasil uji statistik menunjukkan bahwa terdapat hubungan antara kejadian stunting dengan riwayat ASI eksklusif (p=0,002), ketepatan MP ASI (p=0,001), konsumsi kapsul vitamin A (p=0,001), dan kelengkapan imunisasi dasar (p=0,001). Kesimpulan: Ada hubungan antara intervensi gizi spesifik dalam program 1000 HPK dengan kejadian stunting di wilayah kerja Puskesmas Jatiluhur Purwakarta.
Konsumsi minuman berpemanis kemasan pada remaja
Authors: Sari Septi Lidya , Utari Diah Mulyawati , Sudiarti Trini
Published: September 2021

Latar Belakang: Minuman berpemanis kemasan merupakan jenis minuman padat kalori dan tinggi gula, namun rendah nilai gizi. Konsumsi minuman berpemanis secara berlebihan dapat meningkatkan risiko terjadinya penyakit tidak menular, seperti obesitas, diabetes melitus tipe II, dan penyakit kardiovaskular. Tujuan: Penelitian ini bertujuan untuk mengetahui proporsi konsumsi minuman berpemanis kemasan dan mengetahui apakah terdapat perbedaan proporsi konsumsi minuman berpemanis kemasan berdasarkan karakteristik individu dan penggunaan label informasi nilai gizi (ING) pada kalangan remaja. Metode: Desain studi yang digunakan, yaitu cross sectional dengan jumlah responden sebanyak 167 siswa kelas X dan XI pada salah satu SMA swasta (SMAS) di Jakarta Timur. Data diperoleh melalui pengisian kuesioner online dan Semi Quantitative Food Frequency Questionnaire (SQ-FFQ) secara mandiri. Data dianalisis secara univariat dan bivariat dengan uji Chi-Square. Hasil: Tingkat konsumsi minuman berpemanis kemasan pada sebagian besar responden (55,1%) tergolong tinggi (≥3 kali per hari). Hasil analisis bivariat menunjukkan bahwa terdapat perbedaan yang bermakna proporsi konsumsi minuman berpemanis kemasan berdasarkan jenis kelamin (p=0,03) dan kemampuan membaca label ING (p=0,011). Kesimpulan: Tingkat konsumsi minuman berpemanis kemasan cenderung lebih tinggi pada responden laki-laki dan juga pada responden dengan kemampuan membaca label ING rendah.
Hydration process of β-MoO3 powder prepared by pulsed wire discharge method
Authors: Ngo Chu Minh , Hieu Nguyen Duy , Do Thi Mai Dung , Nakayama Tadachika , Niihara Koichi , Suematsu Hisayuki
Published: September 2021

The hydration of β-MoO3 and α-MoO3 powders was investigated through powder exposure experiments at 24 ℃ in the air with a relative humidity of 53%. X-ray diffraction results showed a hydrated phase of MoO3·0.34H2O in only exposed β-MoO3 powder, while the α-MoO3 powder maintained its initial phase. By thermogravimetry-differential thermal analysis and mass spectrometry measurements and the dehydration experiments, the stable temperature range of the hydrated phase made by β-MoO3 was identified below 285 °C, and above this temperature, the hydrated phase transformed back to the original β-MoO3 phase. The other analysis methods using field-emission scanning electron microscopy and field-emission transmission electron microscopy were also used to determine powders’ morphology and size and to confirm phases from their lattice images. To the best of our knowledge, this is the first report on the formation of the hydrated phase by exposing β-MoO3 powder in the humid air.
Meneropong Dampak Stress, Social Skills dan Internet Addiction pada Office Workers semasa Covid-19
Authors:   Jurusan Manajemen, Universitas Bina Nusantara, Jakarta Barat, Novianti Angela , Akhyari Muhammad Rafi ,   Jurusan Manajemen, Universitas Bina Nusantara, Jakarta Barat, Hakim Syifa Nadhifah ,   Jurusan Manajemen, Universitas Bina Nusantara, Jakarta Barat, Saputra Nopriadi ,   Jurusan Manajemen, Universitas Bina Nusantara, Jakarta Barat
Published: September 2021

Abstract Purpose: This study aimed to determine how much coping stress levels, social skills, and internet addiction affect employee engagement of millennial employees during the COVID-19 pandemic. Research Methodology: Questionnaires were distributed to 391 millennial office employees during the Covid-19 pandemic. The samples used were only 196 respondents because we used the Krejcie and Morgan method. The technique used by the author to analyze the data was multiple regression techniques. Results: This study show that social skills and internet addiction affect employee engagement while coping with stress does not affect employee engagement. Limitations: This study focuses on coping stress, social skills, internet addiction, and employee engagement, and only on millennial office workers in Jabodetabek. This is supported by very clear references on coping stress, social skills, internet addiction, and employee engagement Contribution: This research shows how to overcome stress, social skills, and internet addiction that affect employee engagement and shows employee engagement, stress coping, social skills, and internet addiction. This research will help companies to find ways to increase employee engagement in their companies.
Peningkatan Kinerja Lini Perakitan Manual dengan Pendekatan Lean-Kaizen
Authors: Famila Dwi Winati
Published: September 2021

Lean manufacturing merupakan sebuah konsep yang sering digunakan oleh industri untuk mencapai keunggulan kompetitif dengan cara mengurangi pemborosan yang tidak memberi nilai tambah dengan biaya yang minimal. Penelitian ini bertujuan untuk meningkatkan performansi lini perakitan manual yang menghadapi kesulitan untuk mendapatkan performansi maksimum dengan pendekatan Lean-Kaizen. Current state VSM menggambarkan kondisi lini perakitan saat ini guna mengidentifikasi pemborosan yang terjadi dan memfokuskan area perbaikan menggunakan Kaizen. Arah utama strategi Kaizen yang diterapkan yaitu mengurangi waktu siklus serta kegiatan yang tidak memberi nilai tambah dan dideskripsikan melalui future state VSM. Hasilnya, penerapan Lean-Kaizen terbukti secara signifikan dapat meningkatkan produksi harian dan produktivitas lini perakitan.
IMPLEMENTASI BALANCED SCORECARD UNTUK PENGUKURAN KINERJA PELAYANAN IMPORTASI PADA KANTOR PELAYANAN BEA DAN CUKAI BOJONEGORO
Authors: Borneo Bayu Mustika , Heitasari Dwi Nurma , Adi Tri Warcono
Published: September 2021

Balanced scorecard merupakan suatu metode pengukuran kinerja yang dilihat dari sisi keuangan dan non keuangan. Penelitian ini bertujuan untuk mengetahui sistem pengukuran kinerja KPPBC yang meliputi perspektif keuangan, pelanggan, proses bisnis internal, serta pembelajaran dan pertumbuhan. Menggunakan pendekatan penelitian kualitatif deskriptif, dengan mengumpulkan data primer maupun sekunder. Teknik pengambilan data dilakukan dengan cara wawancara, observasi dan kuesioner. Ukuran pada setiap perspektif sebagai operasionalisasi variabel yaitu: untuk perspektif keuangan meliputi pertumbuhan penerimaan bea masuk, tingkat pengeluaran dan efisiensi; untuk perspektif pelanggan meliputi customer satisfaction; untuk perspektif bisnis internal meliputi waktu tunggu dan kinerja pelayanan dan untuk perspektif pembelajaran dan pertumbuhan meliputi peningkatan kapabilitas dan kepuasan pegawai. Untuk mengukur kepuasan pelanggan dan kepuasan pegawai menggunakan survey, yaitu pada kepuasan pelanggan menggunakan purposive sampling dan kepuasan pegawai menggunakan stratified random sampling. Setelah dilakukan penelitian menunjukkan total kinerja importasi KPPBC berdasarkan perspektif pelanggan, perspektif proses bisnis internal, perspektif keuangan, dan perspektif pembelajaran dan pertumbuhan adalah 87%. Dengan presentasi perspektif keuangan 100%, perspektif pelanggan 4,46, perspektif pembelajaran dan pertumbuhan 63%, sedangkan perspektif dengan kinerja terendah terdapat pada perspektif proses bisnis internal dengan capaian 53%. Perspektif keuangan dan pelanggan telah mencapai target dan perspektif pembelajaran dan bisnis internal belum mencapai target.
Effectiveness of Selected Parapheromones for Mass Trapping of Mango Fruit Fly, Ceratitis cosyra Walker and Oriental Fruit Fly, Bactrocera dorsalis Hendel (Diptera: Tephritidae) on Mango
Authors: Ebi C.
Published: September 2021

Mango (Mangifera indica L.) is an important fruit crop in Nigeria. It is a source of essential vitamins and is also cultivated for its nutritional, medicinal and industrial uses. Fruit flies infest various commercial fruit crops and cause economic damage. Mass trapping and male annihilation technique (MAT) has been the most useful and common means of controlling fruit flies with special focus on Bactrocera dorsalis Hendel (Diptera: Tephritidae) on mangoes. The study evaluated the effectiveness of four types of parapheromones namely, methyl eugenol (liquid and solid forms), cuelure, terpinyl acetate and trimedlure for mass trapping of fruit flies on Mango. Modified Lynfield traps containing the parapheromones were randomly set on the mango orchards in three replicates in Nigeria Horticultural Research Institute (NIHORT) orchard, Okigwe, Imo state, Southeast Nigeria. This study was conducted during the mango fruiting period of 2019 season, when the density of fruit flies peaked. Effect of parapheromones on mean number of damaged dropped fruits was also evaluated. The mean population of B. dorsalis and Ceratitis cosyra was significantly higher (P>0.05) in liquid methyl eugenol traps when compared to other parapheromones. Bactrocera dorsalis recorded more than 90% of the fruit flies that were trapped especially in the first 3 weeks of trapping. In orchard I, Liquid methyl eugenol significantly (P<0.05) trapped highest number of B. dorsalis (270.20) in week I and similar trends were observed in orchard II. There was steady decline in damaged dropped mango fruits as the study progressed (Fig. 1 and 2). Use of liquid methyl eugenol was most effective in trapping B. dorsalis and C. cosyra, and it can be incorporated in Integrated Pest Management (IPM) programmes for the control of fruit flies.
Stock Price Prediction Using Deep Learning Models
Authors: Sen Jaydip , Mehtab Sidra , Nath Gourab
Published: September 2021

Prediction of future
movement of stock prices has been a subject matter of many research work. On
one hand, we have proponents of the Efficient Market Hypothesis who claim that
stock prices cannot be predicted, on the other hand, there are propositions
illustrating that, if appropriately modeled, stock prices can be predicted with
a high level of accuracy. There is also a gamut of literature on technical
analysis of stock prices where the objective is to identify patterns in stock
price movements and profit from it. In this work, we propose a hybrid approach
for stock price prediction using five deep learning-based regression models. We
select the NIFTY 50 index values of the National Stock Exchange (NSE) of India,
over a period of December 29, 2014 to July 31, 2020. Based on the NIFTY data during December 29, 2014
to December 28, 2018, we build two regression models using convolutional
neural networks (CNNs), and three regression models using long-and-short-term
memory (LSTM) networks for predicting the open values of the NIFTY
50 index records for the period December 31, 2018 to July 31, 2020. We adopted
a multi-step prediction technique with walk-forward validation. The parameters of the five deep learning
models are optimized using the grid-search technique so that the validation
losses of the models stabilize with an increasing number of epochs in the model
training, and the training and validation accuracies converge. Extensive
results are presented on various metrics for all the proposed regression models.
The results indicate that while both CNN and LSTM-based regression models are
very accurate in forecasting the NIFTY 50 open values, the CNN model
that previous one week’s data as the input is the fastest in its execution. On
the other hand, the encoder-decoder convolutional LSTM model uses the previous
two weeks’ data as the input is found to be the most accurate in its
forecasting results.
A Time Series Analysis - Based Forecasting Approach for the Indian Realty Sector
Authors: Sen Jaydip
Published: September 2021

Prediction of stock prices using time series
analysis is quite a difficult and challenging task since the stock prices
usually depict random patterns of movement. However, the last decade has witnessed
rapid development and evolution of sophisticated algorithms for complex
statistical analysis. These algorithms are capable of processing a large volume
of time series data executing on high-performance hardware and parallel
computing architecture. Thus computations which were seemingly impossible to
perform a few years back are quite amenable to real-time time processing and
effective analysis today. Stock market time series data are large in volume,
and quite often need real-time processing and analysis. Thus it is quite
natural that research community has focused on designing and developing robust
predictive models for accurately forecasting stochastic nature of stock price
movements. This work presents a time series decomposition-based approach for
understanding the past behavior of the realty sector of India, and forecasting
its behavior in future. While the forecasting models are built using the time
series data of the realty sector for the period January 2010 till December
2015, the prediction is made for the time series index values for the months of
the year 2016. A detailed comparative analysis of the methods are presented
with respect to their forecasting accuracy and extensive results are provided
to demonstrate the effectiveness of the six proposed forecasting models.
An Investigation of the Structural Characteristics of the Indian IT Sector and the Capital Goods Sector – An Application of the R Programming in Time Series Decomposition and Forecasting
Authors: Sen Jaydip , Datta Chaudhuri Tamal
Published: September 2021

Time series
analysis and forecasting of stock market prices has been a very active area of
research over the last two decades. Availability of extremely fast and parallel
architecture of computing and sophisticated algorithms has made it possible to
extract, store, process and analyze high volume stock market time series data
very efficiently. In this paper, we have used time series data of the two
sectors of the Indian economy – Information Technology (IT) and Capital Goods
(CG) for the period January 2009 – April 2016 and have studied the
relationships of these two time series with the time series of DJIA indices,
NIFTY indices and the US Dollar to Indian Rupees exchange rate. We established
by graphical and statistical tests that while the IT sector of India has a
strong association with DJIA indices and the Dollar to Rupee exchange rate, the
Indian CG sector exhibits a strong association with the NIFTY indices. We
contend that these observations corroborate our hypotheses that the Indian IT
sector is strongly coupled with the world economy whereas the CG sector of
India is the reflection of India’s internal economic growth. We also present
several models of regression between the time series which exhibit strong
association among them. The effectiveness of these models have been
demonstrated by very low values of their forecasting errors.
Multi-Task Gaussian Process Upper Confidence Bound for Hyperparameter Tuning
Authors: Shen Bo , Gnanasambandam Raghav , Wang Rongxuan , Kong Zhenyu
Published: September 2021

In many scientific and engineering applications, Bayesian optimization (BO) is a
powerful tool for hyperparameter tuning of a machine learning model, materials design
and discovery, etc. BO guides the choice of experiments in a sequential way to find
a good combination of design points in as few experiments as possible. It can be formulated as a problem of optimizing a “black-box” function. Different from single-task
Bayesian optimization, Multi-task Bayesian optimization is a general method to efficiently optimize multiple different but correlated “black-box” functions. The previous
works in Multi-task Bayesian optimization algorithm queries a point to be evaluated
for all tasks in each round of search, which is not efficient. For the case where different tasks are correlated, it is not necessary to evaluate all tasks for a given query
point. Therefore, the objective of this work is to develop an algorithm for multi-task
Bayesian optimization with automatic task selection so that only one task evaluation
is needed per query round. Specifically, a new algorithm, namely, multi-task Gaussian
process upper confidence bound (MT-GPUCB), is proposed to achieve this objective.
The MT-GPUCB is a two-step algorithm, where the first step chooses which query
point to evaluate, and the second step automatically selects the most informative task
to evaluate. Under the bandit setting, a theoretical analysis is provided to show that
our proposed MT-GPUCB is no-regret under some mild conditions. Our proposed algorithm is verified experimentally on a range of synthetic functions as well as real-world
problems. The results clearly show the advantages of our query strategy for both design
point and task.
Góngora y Tirso de Molina: lo culto y lo sorprendente
Authors: Dolfi Laura
Published: September 2021

For the first time, this book parallels the works of Góngora and Tirso, analyzing their different involvement in the expressive modalities of the Baroque that both interpret and value in a hyperbolic way. With efficiency and originality, the renowned hispanist Laura Dolfi studies the style of Soledades, Panegírico, and Cigarrales, and the artifices of fiction that, in Las firmezas de Isabela and La fingida Arcadia, guide the desenlace, underlining the position of its author with respect to the literary precepts of the time (rejection or acceptance of new art and culteranismo). In addition, Góngora’s role as a playwright is valued, and his plays are studied from less accustomed points of view: the dramatic characteristics, the importance of the rhythm that his verses scanned, the diffusion and the possible corruption of the text.
SARS-COV-2 como desencadenante de enfermedades tromboembólicas en el embarazo
Authors: Barrera García Kenneth Andersson
Published: September 2021

OBJETIVO: Describir el SARS-COV-2 como desencadenante de enfermedades tromboembólicas en el embarazo MÉTODO: Se recopiló información de artículos de revistas científicas y metaanálisis. RESULTADOS: Durante la pandemia en el país de Chile se realizaron muestras de PCR, exámenes para detectar el virus (89,2%) fueron mujeres gestantes. Se identificaron patologías asociadas como  Hipertensión en el 9,7% y pacientes con Diabetes Mellitus 1 o 2 en un 8.3%, enfermedades tromboembólicas en un mismo porcentaje. CONCLUSIÓN: Actualmente, la infección por SARS-CoV-2 es una afección en la cual el daño endotelial y la interacción entre factores inflamatorios y tromboticos, posee una característica única, mediada por citoquinas y leucocitos, estableciendo una activación global en la cascada de coagulación, generando la  trombosis masiva provocando tromboembolia pulmonar y trombosis venosa profunda, Se reconoce como un gran reto la prevención del Tromboembolismo Venoso, siempre se debe tener en cuenta, los 3 conceptos iniciales siguientes: “conocer factores de riesgo, realizar un diagnóstico oportuno e indicar el tratamiento profiláctico adecuado”, todas estas gestiones están directamente relacionadas y como principal objetivo la disminución de la mortalidad materna.
Factores determinantes de fotosensibilidad y dermatosis más frecuentes
Authors: Rodríguez Lémus Katherine Dariana
Published: September 2021

En las enfermedades de la piel intervienen muchos factores fotosensibles y pueden llegar a causar lesiones agravantes en la epidermis, hasta causar riegos graves como el cáncer; y las altas tasas de exposición al sol, emiten una amplia cantidad de radiaciones electromagnéticas, pero las más importantes desde el punto de vista dermatológico, son las que pertenecen al espectro fotobiológico porque causan lesiones cutáneas (fotodermatosis).  En general, parecen estar aumentando notablemente en los últimos años en todo el mundo, debido a la tendencia de las modificaciones ambientales provocadas por la contaminación, y ahora es uno de los principales o más consultado problema en salud pública en el mundo. Las organizaciones mundiales de la salud realizan investigaciones con el objetivo de obtener el índice UV más alto donde la ubicación geográfica es un importante determinante para la intensidad de los rayos UV, y su asociación con las enfermedades actínicas agudas de piel. Entre las dermatosis más comunes se mencionan: la urticaria solar, hydroa vacciniforme, erupción polimorfa lumínica, prurigo actínico, dermatitis actínica crónica, por lo cual se determina que la mayoría de pacientes con afecciones por dermatosis, se mantienen en constante exposición a la luz solar, provocando daño y alteración a la estructura de la epidermis, por lo que se puede encontrar una patología de tipo crónico, según el lapso de tiempo de exposición.
Organizasyonel Sessizlik, Düşüş ve Ölüm
Authors: ŞENGÖZ Murat
Published: September 2021

Organizasyonların varlıklarını devam ettirebilmek için başa çıkmaları gereken koşullar ve diğer zorluklarla mücadelelerinde veya çevreye adaptasyonlarında başarılı olamamaları, organizasyonların varlıklarının sona ermesine neden olabilir. Organizasyonlar, yapıları ve işleyişleri, teknik ve insani unsurları ile bir yandan teknik rasyonellik sağlamaya, diğer yandan da insan unsurları ile bir bütün olarak çevrelerine uyum sağlamaya ve varlıklarını devam ettirmeye çalışırlar. Bu yönüyle organizasyonlar, yaşayan birer varlık olarak doğarlar, gelişirler ve ölürler. Bu çalışmada organizasyonların sessizliği, düşüşü ve ölümü yani varlıklarının sona ermesiyle ilgili akademik literatür derlenecektir. Bu çalışmada organizasyonel sessizlik, düşüş ve ölüm kavramları hem anılan yönetim ve örgüt yazınında dolaylı olarak, hem de yabancı yazında doğrudan aktarıldığı şekliyle tanımı, süreci, kaynakları ve sonucu itibariyle ele alınacaktır. Bu çerçevede organizasyonel süreklilik çalışmaları ve geliştirilen perspektifler incelenecek, organizasyonların sessizliğe bürünmesi, düşüşleri ve sona ermesinde ayrışan ve birleşen yönler ortaya koyulmaya çalışılacaktır.
Kırsalda Katılım Bankacılığı Algısı: Oltu Örneği
Authors: DİLMAÇ Murat , SUMER Serpil
Published: September 2021

Bu çalışmada Oltu kırsalında faaliyet gösteren esnafların fon ihtiyaçlarını karşılarken katılım bankalarını tercih edip etmeme durumları ele alınmıştır. Çalışmada veriler anket yöntemi ile elde edilerek SPSS programında analiz edilmiştir. Kategorik değişkenler arasındaki ilişkiyi bulmak için hipotezler oluşturulmuş ve Ki-Kare analizi ile test edilmiştir. Yapılan testler sonucunda medeni durum ile kredi kullanımı arasında ilişki bulunmuş ve kredi kullananlar katılım bankalarının bankacılık sistemi içerisinde yer alması gerektiğini belirtmişlerdir. Ancak hem eğitim durumu ile “kâr payı ve faiz arasında fark olduğu” ifadesi arasında ilişki bulunamamış hem de eğitim durumu ile “katılım bankalarının sisteme dahil edilmesi” arasında ilişki bulunamamıştır. Ayrıca Oltu esnafı katılım bankalarından kredi kullanmayı tercih etmemelerinin nedeni olarak geleneksel bankalarda kredi kullanımının daha kolay olduğunu belirtmişlerdir.
Is COVID-19 forcing ESL instructors to return to more traditional teaching in the second language acquisition methodology?
Authors:   International University of Sarajevo, Bosnia and Herzegovina, Lagumdžija Emina , Eminović-Ljevo Anisa ,   International University of Sarajevo, Bosnia and Herzegovina
Published: September 2021

This paper is part of PhD research conducted by two experienced ESL instructors from the International University of Sarajevo. The aim was to see whether the instructors at the English Language School (ELS) at the International University of Sarajevo (IUS) were turning to some more traditional teaching methods and techniques due to the COVID-19 pandemic and emergency online instruction. Four experienced English Language School instructors were interviewed and special attention was paid to the following aspects of teaching: class activities, feedback, teacher talking time and student-instructor rapport. The results showed that despite being fully experienced with and knowledgeable about modern teaching methods and techniques, more traditional methods seemed to be preferred to modern teaching methods when it came to online instruction. However, to prove this even further, some large-scale and more empirical studies would have to be conducted in the future./ Keywords: in-person instruction, online instructions, modern methodology, traditional methodology, class activities, feedback, teacher talking time, student-instructor rapport
Learning language online – interaction without interaction
Authors:   Josip Juraj Strossmayer University of Osijek, CROATIA, Gusić Laura
Published: September 2021

We live in a time where an (unknown) disease has spread across the globe and is making changes that affect every aspect of life, with that the educational system. Here are known facts: Language – shifting, something that is alive, used by the whole world, a thing that connects us; COVID-19 – shifting, something that destroys lives, spread all around the world, a thing that divides us. Meeting with people became a taboo topic. So, is studying, especially languages, lacking or is change imperceptible? Is a person capable of acquiring the same amount of knowledge when in solitude or a crowd? It is said that genius is 1% inspiration, 99% perspiration but neither is possible if a person sits “locked” in a room. Inspiration can come when a person is alone, but it mostly comes from observing other people, people that surround us. Without an idea or even an outline of it, no work can be done, so that 99% are, in a way, useless. Online classes did just that. All students, and teachers, are doing is sitting behind a screen. Motivate yourself! Easier said than done – it is hard to accomplish something if you do not have someone telling you “You have got this” or even “You will never be able to do this”. Those words, positive or negative, push us forward. Your room and you – only silence. With mathematics, one can put on some background music and spend hours alone solving a task, but with language, one needs to be surrounded by people; one needs to use it in real life to be able to reach the full potential. To return to music – yes, it can be used to acquire a foreign language, but it cannot be the primary or the only way of understanding the complexity behind it.