bluuebunny/crossref_metadata_2025 huggingface dataset:
A Brief Report on the Correlation between Empathy and Gender Sensitivity among Italian Medical University Students
Authors: Savarese Giulia , Carpinelli Luna , Stornaiuolo Giovanna , Bifulco Stefano , Bruno Giorgia , Navarra Marco
Published: February 2024

Background: Gender stereotypes and biases can influence perceptions of competence and suitability for certain medical specialties. Empathy is an important component of an optimal doctor-patient relationship. The scope of our study is to verify the correlation between “empathetic" behavioral style with attention and sensibility to the gender differences of patients of the medical students. Methods: An online survey was conducted using the Jefferson Scale for Empathy (JSE), to measure empathy in the context of health professions education and patient care; and the Nijmegen Gender Awareness in Medicine Scale (N-GAMS), which measures attitudes and assumptions about gender. A total of 234 students (52.1% M; mean age: 22.68±2.48) from Medicine and Surgery at the University of Salerno (Italy) participated, of whom n° 175 were third-year students and n° 59 were fifth-year students. Results: The JSE score shows that male students have higher scores (77.29±12.38) than females (75.91±10.39). Conversely, female students have higher perspective-taking (JSE Factor 1: Male= 51.26±11.84; Female= 52.72±11.88). In addition, third-year students are much more empathetic than their fifth-year colleagues (JSE Score: 3°ys= 77.35±11.46; 5°ys= 74.49±11.33). With reference to the GS, we found that male students have greater sensitivity than their female colleagues (GS: Male= 2.67±0.68; Female= 2.37±0.48); conversely, they have higher scores of gender stereotype towards patients (GRIP: Male= 2±0.88; Female= 1.59±0.61) and doctors (GRID: Male= 1.88±0.89; Female= 1.64±0.63). Also, the third-year students compared to their fifth-year colleagues are characterized by greater gender sensitivity (GS: 3°ys= 2.57±0.62; 5°ys= 2.42±0.57), less bias with respect to patients (GRIP: 3°ys= 1.77±0.79; 5°ys= 1.90±0.78) but, on the other hand, show more stereotypes and prejudices towards doctors (GRID: 3°ys= 1.77±0.81; 5°ys= 1.75±0.74). Conclusions: Humanistic attitudes, including empathy, should be instilled, and evaluated among trainees as an essential part of their postgraduate medical education.
Diagnostic Challenges in Inflammatory Choroidal Neovascularization
Authors: Karska-Basta Izabella , Pociej-Marciak Weronika , Żuber-Łaskawiec Katarzyna , Markiewicz Anna , Chrząszcz Michał , Romanowska-Dixon Bożena , Kubicka-Trząska Agnieszka
Published: February 2024

Inflammation plays a key role in the induction of choroidal neovascularization (CNV). Inflammatory choroidal neovascularization (iCNV) is a severe but uncommon complication of both infectious and non-infectious uveitides. It is hypothesized that its pathogenesis is similar to that of wet age-related macular degeneration (AMD), and involves hypoxia as well as the release of vascular endothelial growth factor, stromal cell-derived factor 1-alpha, and other mediators. Inflammatory CNV develops when inflammation or infection directly involves the retinal pigment epithelium (RPE)–Bruch’s membrane complex. Inflammation itself can compromise perfusion, generating a gradient of retinal-choroidal hypoxia that additionally promotes the formation of choroidal neovascularization in the course of uveitis. The development of choroidal neovascularization is extremely common in conditions such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and presumed ocular histoplasmosis syndrome. Although the majority of iCNV cases are well defined and appear as the “classic” type on fluorescein angiography, the diagnosis of iCNV is challenging due to difficulties in differentiating between inflammatory choroiditis lesions and choroidal neovascularization. Modern multimodal imaging, particularly the recently introduced technology of optical coherence tomography (OCT) and OCT angiography (noninvasive and rapid imaging modalities) can reveal additional features that aid the diagnosis of iCNV. However, more studies are needed to establish their role in the diagnosis and evaluation of iCNV activity. Keywords: uveitis; inflammatory choroidal neovascularization; multimodal imaging; fluorescein angiography; indocyanine green angiography; optical coherence tomography; optical coherence tomography angiography; near-infrared autofluorescence
Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth
Authors: Ruggiero Carmelinda , Tafaro Laura , Cianferotti Luisella , Tramontana Flavia , Macchione Ilaria Giovanna , Caffarelli Carla , Virdis Agostino , Ferracci Marika , Rinonapoli Giuseppe , Mecocci Patrizia , Napoli Nicola , Calsolaro Valeria
Published: February 2024

Aging is the results of several complex and multifactorial processes, where several agents contribute to increase intrinsic vulnerability and susceptibility to age-related diseases. The hallmarks of aging are a set of biological mechanisms, finely regulated and strictly interconnected, initiating or contributing to biological changes anticipating several age-related diseases. The complex network of cellular and intercellular connections between the hallmarks might represent a possible target for the research of agents with pleiotropic affects. Vitamin D (VitD) is known to have positive impact not only on muscle and bone health, but also on several extra-skeletal districts, due to the widespread presence of VDRs (VDR). VitD and VDR could be molecules potentially targeting the hallmark of aging network. To date, evidence about the potential effect of VitD on the hallmark of aging is scarce in humans and mainly based on preclinical models. Although underpowered and heterogeneous, in-human studies seems to confirm the modulatory effect of VitD on some hallmarks aging and diseases. However, more investigations are needed to clarify the pleiotropic effects of VitD and its impact on the hallmark of aging, hopefully highlighting the courses for translational applications and potential clinical conclusions.
The Mediating Effect of Lack of Social Interaction and Financial Stress between COVID-19 and Domestic Violence: A Post-COVID Scenario of Pakistan
Authors: Suleman Danish , Iqbal Faiza
Published: February 2024

Purpose: The pandemic, named COVID-19, which shook global economy, production and trade has equally affected the social and domestic lives of ours. In this study the COVID-19’s impact has been investigated on lack of social interaction, financial stress and how it influences the domestic violence in a developing country like Pakistan. The study focuses on some of the important factors that are root causes of increased domestic violence in Pakistan.
Design/methodology/approach: The study is quantitative and survey questionnaire has been conducted for structural equation modelling (SEM) to evaluate the hypotheses. The modified scale was validated using confirmatory factor analysis, the Purposive and snowball sampling technique is used for collecting data from 200 respondents of Punjab Pakistan for data analysis through SPSS and SmartPLS.
Findings: It is revealed that Covid 19 has a significant effect on lack of social interaction and financial stress. Moreover, lack of social interaction and financial stress also enhances domestic violence. Finally, lack of social interaction and financial stress mediates COVID-19 and domestic violence.
Originality/value: This study appears to be frontier research which determines the impact of COVID-19 on lack of social interaction, financial stress and domestic violence particularly in a developing country like Pakistan.
Review of the Integration of Hybrid Electric Turbocharger for the Mass-Produced Road Vehicles
Authors: Suciu Cosmin Constantin , Igret Sorin Vlad , Vetres Ion , Ionel Ioana
Published: February 2024

This study conducts a comprehensive review of the integration of Hybrid Electric Turbochargers in mass-produced road vehicles. The primary objective is to inform the readers about the potential advantages and innovative applications of HETs. Employing a SWOT analysis, the research compares the performance of HETs on thermal engines versus traditional turbochargers and HETs on thermal engines versus HETs on hybrid engines based on a synthesis of multiple research findings. The study elucidates the fundamental mechanics of turbochargers, emphasizing their inherent benefits. Additionally, it introduces a novel approach with the integration of the hy-brid-electric turbocharger, demonstrating its capacity, supported by practical examples. The in-corporation of turbochargers with energy recovery mechanisms, including HETs, is shown to significantly contribute to emissions reduction. Moreover, the electric drive facilitates the utili-zation of hybrid turbines, particularly on low-displacement engines, resulting in enhanced effi-ciency, torque, and liter power. In conclusion, the research underscores the potential of HETs to substantially mitigate the environmental impact of the transportation sector by reducing emis-sions and conserving energy. Their ability to optimize the fuel efficiency and power output of internal combustion engines, coupled with the feasibility of downsized engines, positions HETs as an attractive option for both manufacturers and consumers. However, it is acknowledged that the implementation of HETs is in its early stages, necessitating further research to comprehensively understand their environmental impact. Despite this, the promising positive impact on the en-vironment designates HETs as a technology deserving close attention in the forthcoming years.
Existence and Limit Behavior of Constraint Minimizers for a Varying Nonlocal Kirchhoff Type Energy Functional
Authors: Zhu Xincai , Wu Hanxiao
Published: February 2024

In this paper, we study the constrained minimization problem for an energy functional which is related to the following Kirchhoff type equation
\begin{equation*}
-\Big(\eta+b\big(\int_{\R^{3}}|\nabla u|^{2}dx\big)^{s}\Big)\Delta u+V(x)u=\mu u +\lambda|u|^{p}u,\end{equation*}
where $b$ is a positive constant, parameters $\eta\geq0, \lambda>0$, exponents $s>0$, $0
Surgical management of stress urinary incontinence: multiple modalities in the absence of a standard technique
Authors:   Karaganda Medical University, Karaganda, Republic of Kazakhstan, Sevastyanov L.V. ,   Alanda Clinic, Karaganda, Republic of Kazakhstan, Turgunov E.M. ,   Karaganda Medical University, Karaganda, Republic of Kazakhstan, Avilova E.V. ,   Alanda Clinic, Karaganda, Republic of Kazakhstan
Published: February 2024

Stress urinary incontinence is a common pathology among middle-aged and older women that significantly reduces the quality of life. According to numerous data, despite the introduction of new technologies in the surgery for stress urinary incontinence, the results of treatment remain unsatisfactory, and addressing the problem of urinary incontinence in women is still one of the priority tasks in modern urogynecology. The article presents general information about the causes of this condition, ultrasound diagnostic approach, advantages and disadvantages of sling operations as the most common method of surgery for stress urinary incontinence. Technical specifications for synthetic sling placement are discussed. Key words: treatment, sling tension, stress urinary incontinence
Application of the Halal Guarantee System to Broilers in Traditional Markets: Worker’s Knowledge of Halal Guarantee
Authors: Handayani Nur Atikah , Nahariah Nahariah , Asnawi Aslina , Hikmah Hikmah
Published: February 2024

The Indonesian government's efforts to support food and beverage products that must be halal-certified by 2024 are by implementing a halal product guarantee system in the industry. One of the industries that must implement halal guarantees is poultry slaughterhouses. One of the criteria for a halal assurance system in a poultry slaughterhouse is the role of human resources.  This study aims to analyze the knowledge of human resources in Poultry Slaughterhouses. Application of knowledge about commitment and responsibility consists of halal criteria, human resource development, top management responsibilities, and training of halal staff. The object of research is poultry slaughterhouses that have implemented SNI halal standards and have not implemented SNI halal standards. The study used 52 samples using 2 technic, field studies consisting of observation, interview, questionnaire, documentation, and literature study techniques. Assessment of respondents' knowledge using the order of assessment (Likert scale). The knowledge of workers in an SNI halal standards poultry slaughterhouse regarding commitment and responsibility was in the very high category. However, poultry slaughterhouses do non-SNI halal standards have a very low category.
Keywords: poultry slaughterhouses, knowledge, halal
On the issue of carious disease as a global medical and sociological problem.
Authors:   N. A. Semashko National Research Institute of Public Health, Stepanova Y. S. , Mingazova E. N. ,   N. A. Semashko National Research Institute of Public Health,   Kazan State Medical University
Published: February 2024

High levels of prevalence of caries disease among the population of various countries have become the basis for including this pathology in the list of civilization-related problems. The complexity of the prospects for reducing the medical and sociological significance of caries disease is noted by most researchers who study the specifics of its course among representatives of various states and social groups. It has been determined that at present the global dental community has not been able to develop a unified strategy that guarantees a reduction in the medical and social risks of caries development. This fact is determined by differences in lifestyle, food preferences, level of education of the population of different countries and territories, in the functioning of health insurance systems and the distribution of medical personnel, in the territorial and geographical characteristics of states, and a number of other factors.
Modeling the process of attracting personnel to medical organizations providing medical care to the rural population.
Authors:   Cinimex, Meshcheryakov A. O.
Published: February 2024

The shortage of medical specialists and their disproportionate distribution both across territories and specialties is a global health problem. According to the Russian Federal State Statistics Service, the shortage of medical personnel as of 2022 is 84.7 thousand people, of which 26.5 thousand are doctors; compared to 2021, the problem of shortage of nursing staff is less acute, but the shortage of doctors remains. An integral part of personnel policy is the process of retaining qualified specialists. The complex motivations of employees to stop or continue working in an organization interact with the personnel decisions of a healthcare organization, which in turn requires a joint study of both the characteristics of the employees and the characteristics of the organization. Purpose of the study is to model the process of attracting personnel to medical organizations providing medical care to the rural population. Materials and methods. Data on 151 students of targeted training who entered the Orenburg State Medical University in 2011 were studied. Using machine learning methods, a mathematical model was built that allows identifying students of targeted training with a higher probability of attraction to the medical organization. Results. The presented data set is unbalanced in terms of the target variable, since only 16.8% of students continued to work in the organization. Among all the options, the most optimal in cross-validation was the use of a decision tree using weights to balance the classes. All studied medical organizations can be divided into 3 groups: organizations with a low level of attraction of specialists, organizations with an average level of attraction of specialists and organizations with a high level of attraction of specialists. Based on the data obtained and analysis of publications, measures were proposed to improve the personnel policy of medical organizations of each type. Findings. Therefore, healthcare organizations have the opportunity to monitor the attraction process of targeted students through factors related to the characteristics of the organization, such as working conditions, reputation and image, career opportunities, and others.
Responsibility of Tin Mining Business Licenses for Environmental Pollution Based on the Polluter Pays Principle
Authors: Rahayu Sri , Permatasari Bunga , Kusuma Winanda
Published: February 2024

The purpose of writing this article is to find out and analyze the polluter pays principle concept and its regulations in Indonesia, as well as to find out and analyze the accountability of tin mining business permits for environmental pollution based on the polluter pays principle. Therefore the research method used in this article uses a normative juridical method with a conceptual approach and statutory approach. The article reveals that PPP in Indonesia involves both preventive and repressive measures to address environmental pollution. Polluters are charged with compensation, but regulations like UUPPLH and Minerba Law are more repressive. Implementation involves guarantee, pollution, and conservation funds, funded by APBN/APBD grants/donations. PT. Timah, as the largest tin IUP holder in Babel, has carried out 100% reclamation, but overall, of the total IUP holders in Babel, these funds are apparently not commensurate with the damage that arises as a result of tin mining exploitation activities. And the number of newly reclaimed areas is 1.59% of the total IUP that has been granted. And the form of civil liability is regulated in the UUPPLH, while criminal liability is regulated in the Minerba Law.
The Influence of Transfer Pricing, Leverage, Profitability, and Earnings Management on Tax Avoidance Moderated by Institutional Ownership (An Empirical Study of Manufacturing Companies)
Authors: Nugroho Danang Widhi , Sunarsih Uun , Zulfiati Lies
Published: February 2024

This research delves into the multifaceted relationships between Transfer Pricing, Leverage, Profitability, Profit Management, and Tax Avoidance, with the moderating influence of Institutional Ownership in manufacturing companies listed on the Indonesia Stock Exchange (BEI). The study employs a descriptive research design with a quantitative approach, utilizing a multiple linear regression-based method through EViews. The research population comprises manufacturing companies listed on the Indonesia Stock Exchange (BEI) between 2020 and 2021. The purposive sampling method was employed, resulting in a sample of 81 manufacturing companies, totaling 162 observations. Secondary data were collected from the official IDX website www.idx.co.id and www.yahoofinance.com. The findings indicate that Transfer Pricing and Leverage exhibit a significant positive influence on Tax Avoidance in manufacturing companies, while Profitability demonstrates a significant negative effect on Tax Avoidance. Conversely, Profit Management does not exhibit a significant impact on Tax Avoidance. Moreover, Institutional Ownership is identified as a moderator, strengthening the influence of Transfer Pricing and Leverage on Tax Avoidance. However, Institutional Ownership does not reinforce the influence of Profitability and Profit Management on Tax Avoidance. This research contributes valuable insights for policymakers, tax authorities, and corporate practitioners, highlighting the nuanced dynamics of Transfer Pricing, Leverage, Profitability, and Profit Management in shaping tax avoidance strategies, particularly in the context of manufacturing companies in Indonesia.
Optimizing the Role of BUMDes Through The Utilization of Herbal Chili Production Potential in Pekandangan Tengah Village, Bluto District, Sumenep Regency
Authors: Djulaeka Djulaeka , Zulkifli Makhmud
Published: February 2024

This study aims to see or measure the financial performance of BUMDes Bina Sejahtera in Pekandangan Tengah village, Bluto sub-district, Sumenep district, which is expected to be able to improve village welfare through contributions to village original income obtained from BUMDes contributions. This research is a qualitative and quantitative descriptive study by looking at the economic potential of the village and the performance of BUMDes through the ROE (return on equity) ratio. Samples were taken from herbal chili farmers as many as 10 people by purposive sampling and 1 BUMDes. The results of this study indicate that the income of herbal chili farmers is quite good but their sales are through middlemen or agents, while the performance of BUMDes with ROE benchmarks below 2% per year has not contributed to the village's original income (PADes).
Plan de marketing: shampoo ecológico (CR)
Authors:   , Calloapaza Gil Christian Anthony , Girau Mendoza Johan Manuel , Vasquez Pinedo Jesus Alberto
Published: February 2024

Licari (2022) menciona que el análisis de Pestel es una herramienta descriptiva que permite conocer el contexto del entorno sobre el cual una empresa desea involucrarse, profundiza sobre las principales variables y fuerzas que ejercen presión en las empresas y los elementos que la rodean. Permite además evaluar la perspectiva de crecimiento de una organización a través de la identificación de agentes externos que puedan interrumpir el desarrollo de las operaciones y es el complemento de un análisis FODA.
Tensión compresiva en el cierre de diastemas en carilla de resina: un análisis de elementos finitos
Authors:   , Reyes Alvear Juan Antonio
Published: February 2024

Objetivo: Analizar la tensión compresiva en el cierre de diastemas en carilla de resina mediante un análisis de elementos finitos. Método: En este estudio in silico se diseñó dos modelos para evaluar la tensión ante fuerzas de 100 N horizontales (modelo 1) y oblicuas 30 grados en palatino (modelo 2) de carillas directas de resina (grosor 0,5 mm) aplicadas en incisivos centrales superiores para el tratamiento de cierre de diastemas (2 mm) mediante el software Solidworks 2017. El máximo y mínimo estrés generado se evaluó con la escala de valores y colores de Von Mises en Megapascales (MPa). Resultados: La máxima tensión compresiva de la carilla fue de 40,3 MPa en el modelo 1 y de 30,1 MPa en el modelo 2, ambas en cervical. Mientras que una mínima tensión de 0,006 MP se observó en incisal del modelo 2. Conclusión: Las carillas directas de resina fueron una opción rápida de tratamiento para cerrar diastemas de 2 mm, aunque los resultados pueden variar según la técnica y el material utilizado.
Efectos de microorganismos eficientes (EM) en el enraizamiento y desarrollo vegetativo de cladodios de pitahaya (Hylocereus undatus)
Authors:   , Carrera Abanto Elvis Michael
Published: February 2024

La principal forma de propagar la pitahaya (Hylocereus undatus) es de manera vegetativa por lo que es importante la calidad del material vegetativo utilizado, ya que de ello depende el resto del proceso productivo. El objetivo de esta investigación fue determinar los efectos de los microorganismos eficientes (EM) en el enraizamiento y desarrollo vegetativo de cladodios de pitahaya (Hylocereus undatus). Las evaluaciones se realizaron en unidades experimentales homogéneas, con 48 cladodios de pitahaya de 30 cm, los factores de estudio fueron los EM en dosis de 25 ml/L, 50 ml/L y 75 ml/L. Se utilizó un diseño completamente al azar (DCA) con cuatro tratamientos y doce repeticiones. Los datos obtenidos fueron sometidos ANOVA y posteriormente a la comparación de medias (Tukey, p ≤ 0.05). Los resultados evidenciaron que la aplicación de EM influyó significativamente en la longitud de brote, peso fresco y peso seco de brote, así como en la longitud de raíz, peso fresco y peso seco de raíz, logrando incrementar sus valores con la aplicación de 75 ml/L de EM (T3). Los parámetros evaluados en cada variable tuvieron una tendencia al incremento a medida que la dosis aplicada fue mayor. Sin embargo, no se encontraron diferencias significativas en las medias en todas las variables a dosis de 50 ml/L de EM (T2) y 75 ml/L de EM (T3).
Efecto de una intervención combinada de mindful eating y educación nutricional en la calidad de la dieta de mujeres adultas con sobrepeso residentes de Lima Metropolitana
Authors:   , Limo Lazarte Francesca Camila
Published: February 2024

Introducción: La conducta alimentaria, influenciada por factores psicológicos y emocionales, desempeña un rol fundamental en la calidad de la dieta y puede contribuir al desarrollo de sobrepeso, un factor de riesgo para el desarrollo de enfermedades crónicas no transmisibles. Frente a esta situación, resulta necesario abordar al paciente de una manera integral, por eso técnicas como el mindful eating o alimentación consciente surguen como una herramienta prometedora para mejorar la conducta alimentaria. En ese contexto el objetivo del estudio fue determinar el efecto de una intervención combinada de mindful eating y educación nutricional en la calidad de la dieta de mujeres adultas con sobrepeso. Materiales y métodos: El presente estudio es un piloto, tipo ensayo clínico aleatorizado longitudinal. Se reclutaron 51 participantes y se dividieron en 3 grupos: educación nutricional, mindul eating, una combinación de ambas. La intervención se realizó de manera virtual durante 7 semanas. Las variables evaluadas fueron la calidad de la dieta, alimentación emocional. Resultados: 24 participantes completaron el estudio. Al finalizar la intervención los 3 grupos mostraron mejoras en la calidad de la dieta (p valor 0,239), comedor emocional (p valor 0,658), actividad física (p valor 0,983); sin embargo, las diferencias no fueron significativas. Conclusiones: Las intervenciones combinadas de mindful eating con educación nutricional o las intervenciones aisladas pueden tener un efecto positivo para mejorar la calidad de la dieta, reducir el comer emocional en mujeres con sobrepeso sin comorbilidades. Sin embargo, no se encontraron diferencias estadísticamente significativas por lo cual se requieren estudios futuros con muestras más amplias y que realicen un seguimiento a largo plazo para evaluar la efectividad de estas intervenciones.
Estado de salud bucal de los tejidos duros y características ocupacionales de trabajadores de una empresa constructora en Lima-Perú, 2021
Authors:   , Manrique Chavez Jorge Enrique
Published: February 2024

Objetivo: Describir las lesiones en tejidos dentarios y trastornos de la salud bucal encontradas durante el examen médico ocupacional en trabajadores del sector construcción de Lima, Perú. Material y Métodos: Estudio epidemiológico transversal realizado en 150 trabajadores del sector construcción, seleccionados mediante muestro aleatorio simple. Se realizó una evaluación estomatológica mediante observación directa y se empleó un instrumento de evaluación odontológico-ocupacional con índices para caries dental, severidad de caries y traumatismos dentales e indicadores de consecuencias clínicas de caries no tratada (patología pulpar) y lesiones no cariosas. Resultados: La experiencia de caries de los operadores sin estudio superior (CPOD = 14,99) y con estudio superior (CPOD = 13,06) fue superior frente a los supervisores (CPOD = 8,23) y administrativos (CPOD = 5,08). Los trabajadores operadores sin estudio superior (SiC = 18,04) y con estudio superior (SiC = 17,17) presentaron peores indicadores de significancia de caries frente a los supervisores (SiC = 13,67) y administrativos (8,25). Además, presentaron mayor carga de consecuencias clínicas de caries no tratada (PUFA = 2,35, severidad = 9,2%) en comparación a los operativos con estudio superior (PUFA = 1,91, severidad = 8,4%), supervisores (PUFA = 0,53, severidad = 2,1%) y administrativos (PUFA = 0,46, severidad = 1,8%), así como mayor frecuencia de lesiones no cariosas (47,3%) y traumatismos dentales (21,3%). Conclusiones: La salud dental, sus consecuencias clínicas y la estructura de los tejidos dentarios de los trabajadores operativos de una empresa constructora se encuentra más afectada en comparación a los otros grupos laborales de la misma empresa.
Co-Occurrence of Pseudopregnancy, Pyometra, and Bacterial Parasitic Anaplasmosis in a Persian Cat
Authors: Budiono Novericko Ginger , Rahmiati Dwi Utari , Tuliman Nurul Annisa , Delimasari Zahrizada Zamrudina , Murtiningrum Fitria Senja , Adistya Erly Rizka , Nugraha Arifin Budiman , Silvarajoo Keertana , Milna Resi
Published: February 2024

An intact female tabby Persian cat, 26-month-old, was brought to IPB University Veterinary Teaching Hospital on the 21st of February, 2023, due to vaginal discharge, inappetence, and lethargy. Physical examination revealed a distended abdomen, mammary gland enlargement, and fever (40.1 °C). The heart and respiratory rates were 128 beats per minute and 32 times per minute, respectively. The patient body weight was 3.87 kg. The veterinarian palpated masses inside the abdominal cavity and observed obvious purulent and haemorrhagic vaginal discharge. Haematology showed leukopenia and thrombocytopenia, and the eosinophil percentage of white blood cells was increased (eosinophilia). Blood chemistry analysis showed hyperglycaemia. Ultrasonography showed two hyperechoic masses inside two hypoechoic pouches in the queen’s uterus, suspected as two dead foetuses (no heartbeat). Roentgen revealed abnormalities in the vena cava caudalis, bronchial pattern in the lung, radioopaque masses in the ventral abdomen, radio-opacity changes in the small and large intestines, and abnormalities in the spleen. The patient’s diagnosis was pyometra, and ovariohysterectomy surgery was performed on the patient. The patient was treated with additional medicines (antibiotics and others) according to the symptoms. The patient’s symptoms disappeared, except for the fluctuating febrile and pale mucous membrane. A blood smear performed on the 1st of March 2023 revealed Anaplasma phagocytophilum (A. phagocytophilum) in the white blood cells, and immediately doxycycline treatment (10 mg/kg body weight, twice daily) was given. The patient was discharged from the hospital on the 14th of March, 2023, with no febrile or other symptoms reported. This case is the first report of open cervix-type pyometra and anaplasmosis co-occurrence in a Persian cat from IPB University Veterinary Teaching Hospital in Indonesia.
A Descriptive Study of Knowledge, Attitude, and Awareness of Basic Life Support Among the Students of the Faculty of Veterinary Medicine
Authors: Jasa Zafrullah Khany , Putra Teuku Romi Imansyah , Al-Mathari Alif , Farhana Rika , Zulkifli Baidillah
Published: February 2024

Basic life support (BLS) is a first-aid measure performed to restore vital organ functions in cardiac or respiratory arrest patients. This research was conducted on the students of the Veterinary Medicine Faculty in the 2018th and 2019th entry years from November 15th – 30th, 2021. This study was a descriptive observational study using a cross-sectional research design. Two hundred two respondents in this study were selected by stratified random sampling. Data from respondents were collected using an online questionnaire via Google Forms. The results of this study indicated that most respondents were 20 years old (46.5%), female (65.8%), and the number of respondents from each generation was the same. The data analysis of the respondents' basic life support showed that they possessed a minimal level of knowledge (60.9%), good attitude (66.8%), and good awareness (56.9%). According to these findings, most students had positive attitudes and awareness of basic life support. The aspect of knowledge about basic life support practices among these students falls into the poor category; therefore, there is a need to step up the socialization and training process.
Robot-assisted radical cystectomy with the clinical application of "Y-shaped" end-to-side ureteral anastomosis in elderly and obese patients
Authors: Mou Yixuan , Mao Yeqing , Liu Zhenghong , Zhang Pu , Shou Jiafeng , Yang Yunkai , Qi Xiaolong , Zhang Dahong , Wo Qijun
Published: February 2024

Objective: To investigate the clinical effect and safety of "Y-shaped" end-to-side ureteral anastomosis with robotic endoscopic technique in radical cystectomy (RC) and urinary diversion (UD) in elderly and obese patients with bladder cancer.
Materials and methods: We retrospectively reviewed the records of 10 patients with bladder cancer who underwent robot-assisted laparoscopic radical cystectomy and "Y-shaped" end-to-side ureteral anastomosis under general anesthesia at Zhejiang Provincial People's Hospital (Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China, 310014) from October 2018 to January 2021. Demographic and clinical data are summarized. The incidence of postoperative complications such as papillary retraction, ureteral stricture, anastomotic stenosis, anastomotic fistula and ureteral calculi were observed and analyzed.
Results: A total of 10 elderly and obese patients successfully underwent RC with "Y-shaped" end-to-side ureteral anastomosis in this research. Median age was (80.6±5.7)y and BMI was (25.12±3.83) kg/m2. The operation time was (95±26) min and the estimated intraoperative blood loss was (100.5±35.6) ml, with no perioperative blood transfusion and no readmission 30 days after operation. No serious complications above Clavien-Dindo grade 4 occurred in the early (≤30 d) and late (> 30 d) after surgery. 1 patient developed fever 3 days after operation and was cured by strengthening anti-infection. 1 patient had a small amount of urine leakage at the anastomotic site after operation, and recovered after strengthening nutrition and maintaining the patency of abdominal drainage tube and single J tube. Postoperatively, the patients replaced the single J tube regularly and were followed up for 3-28 months (average 15 months) until April 10, 2021. In 2 cases, the ureterostomy nipple was slightly retracted and collapsed without special treatment. 1 case formed ureteral calculi and was treated conservatively. No ureteral stenosis, necrosis, anastomotic stenosis or severe anastomotic fistula, hernia around the stoma occurred. No visceral metastases or new lesions of urothelial carcinoma were observed. All patients were satisfied with the postoperative quality of life.
Conclusions: The robot-assisted "Y-shaped" end-to-side ureteral anastomosis technique performed intracorporeally seems to be a straightforward, secure, and viable approach. It is considered suitable for radical resection of bladder cancer and urinary diversion in elderly and obese patients.
Enhancing genomic data synthesis: A WGAN-GP approach for haplotype generation and evaluation using quasi Manhattan Wasserstein distance
Authors: Lim Evan Unit , Lim Aylwin Ming Wee , Fann Cathy SJ
Published: February 2024

Background
The utilization and translation of genomic data from large biobanks has revolutionized the field of biomedical research, drug development and precision medicine. Despite the advances in genetic epidemiology research, limited sample size of certain rare diseases and minority population remains a critical issue. As an alternative to collecting more samples, generating realistic synthetic human genomic data by mimicking the population structure can uplift the sample size of disease cohorts or minority groups. The recently proposed Generative Adversarial Networks (GANs) for generating artificial genomes still requires extensive hyperparameter tuning and often fails to converge.
Results
We utilized WGAN-GP on phased haplotype data sourced from individuals with type 1 diabetes (T1D: n=3,698) and a disease-free cohort (healthy: n=51,857) from the UK Biobank. Subsequently, synthetic datasets were generated, doubling the size of the original samples (TID': n=7,396, healthy': n=103,714). The input data comprised haplotype pairs with selected single nucleotide polymorphisms (SNPs), notably rs6679677 and rs2476601 in the PTPN22 gene, identified in previous genome-wide association studies (GWAS) as linked to increased T1D risk. We evaluated WGAN-GP’s ability to capture the complex multidimensional structure of the input data through Jensen–Shannon divergence, cosine distance, and a novel quasi Manhattan Wasserstein distance. Additionally, we demonstrated the two-dimensional principal component analysis (PCA) representation of real and synthetic data and showcased the allele frequencies between real and synthetic data. We introduced the Quasi Manhattan Wasserstein Distance (QMWD) and explored its potential in training.
Conclusions
The study highlights the potential of WGAN-GP in synthetic genomic data generation, addressing challenges faced by traditional GANs. QMWD, with O(n) efficiency, offers a promising avenue for improvement.
NOL10 is required for NUP98-DDX10 leukemia
Authors: Kitabayashi Issay , Shima Yutaka , Yamagata Kazutsune , Sasaki Kazuki
Published: February 2024

NUP98 rearrangements associated with acute myeloid leukemia and myelodysplastic syndromes generate NUP98-fusion proteins. One such fusion protein, NUP98-DDX10, contains the putative RNA helicase DDX10. The molecular mechanism by which NUP98-DDX10 induces leukemia is not well understood. Here, we show that 24 amino acids within the DDX10 moiety of NUP98-DDX10 are crucial for cell immortalization and leukemogenesis. NOL10, nucleolar protein 10, interacts with the 24 amino acids, and NOL10 is a critical dependency of NUP98-DDX10 leukemia development. Studies in a mouse model of NUP98-DDX10 leukemia showed that loss of Nol10impaired disease progression and improved survival. We also identified a novel function of NOL10 in that it acts cooperatively with NUP98-DDX10 to regulate serine biosynthesis pathways and stabilize ATF4 mRNA. Collectively, these findings suggest that NOL10 is a critical regulator of NUP98-DDX10 leukemia, and that targeting NOL10 (or the serine synthesis pathway regulated by NOL10) may be an effective therapeutic approach.
Mendelian randomization distinguished the changes in gut microbiota caused by IBD from those that lead to IBD
Authors: Li Fan , Han Xiaoping , Tang Tongyu , Wang Zhaodi , Zhao Qi , Wang Zhi , Xu Zifeng , Chang Yu , Gou Zhaoyang , Li Yuqin
Published: February 2024

Observational studies have reported that dysbiosis of gut microbiota may be a contributing factor in the development of IBD. However, the causal relationship between gut microbiota and IBD remains unclear due to the coexistence of gut dysbiosis in IBD patients. The aim of this study is to investigate the causal and reverse causal relationships between gut microbiota and inflammatory bowel disease (IBD).We aimed to explore the causal and reverse causal relationships between gut microbiota and IBD using a two-sample Mendelian randomization (MR) approach. Specifically, genetic variants associated with IBD were selected from the International IBD Genetics Consortium (IIBDGC) trans-ancestry genome-wide association studies (GWAS), while data related to gut microbiota were obtained from the International MiBioGen consortium. We employed various MR methods, including inverse variance-weighted (IVW), MR-Egger regression, weighted median, weighted mode, and MR-RAPS. Sensitivity analyses using MR-Egger intercept test, Cochran's Q test, and leave-one-out test were conducted for quality control.As results, Bifidobacteriaceae, Bifidobacterium, Lactobacillaceae, Lachnospiraceae UCG008 and Paraprevotella reduce the risk of CD. Family XIII AD3011 reduces the risk of CD and UC. Clostridiales vadin BB60 group reduces the risk of UC. Lachnospiraceae UCG010 genus, Oxalobacteraceae, Oxalobacter and Intestinimonas promotes CD development. Paraprevotella, Eubacterium ruminantium and Prevotellaceae genus promotes UC development. Eubacterium coprostanoligenes, Ruminococcaceae UCG005 genus promotes CD and UC development.Based on Cochran's Q test and MR-Egger intercept, there is no evidence of potential heterogeneity or pleiotropy bias in our findings. In conclusion, this study suggests that the use of novel probiotics for adjunctive therapy in IBD may present a new avenue for future IBD treatment.
Assessing the efficiency of sustainable agricultural development from the perspective of agricultural production-government poverty reduction-rainfall interactions：evidence from China
Authors: Wang Jianlin , You Zhanglan , Song Pengfei , Fang Zhong
Published: February 2024

The quest to eradicate poverty, central to the United Nations Sustainable Development Goals (SDGs), poses a significant global challenge. Advancement in sustainable rural development is critical to this effort, requiring the seamless integration of environmental, economic, and governmental elements. Previous research often omits the complex interactions among these factors. Addressing this gap, this study evaluates sustainable rural development in China by examining the interconnection between agricultural production and government-led poverty reduction, with annual rainfall considered an influential factor of climate change impacts on these sectors and overall sustainability. Utilizing a Meta-frontier entropy network dynamic Directional Distance Function (DDF) within an exogenous Data Envelopment Analysis (DEA) model, we categorize China's 27 provinces into southern and northern regions according to the Qinling-Huaihe line for a comparative study of environmental, economic, and governmental efficiency. This innovative approach overcomes the limitations of previous static analyses. The findings reveal: (1) Rainfall, as an exogenous variable, significantly affects agricultural production efficiency. (2) The overall efficiency in both southern and northern regions increases when accounting for rainfall. (3) Government effectiveness in poverty reduction is comparatively lower in the northern region than in the southern region when rainfall is considered. These insights underscore the importance of including climatic variables in sustainable development policies and emphasize the need for region-specific strategies to bolster resilience against climatic challenges.
Energy Efficient Cluster-Based Routing Protocol for WSN using Multi-Strategy Fusion Snake Optimizer and Minimum Spanning Tree
Authors: Yang Le , Zhang Damin , Li Lun , He Qing
Published: February 2024

In recent years, the widespread adoption of wireless sensor networks (WSN) has resulted in the growing integration of the Internet of Things (IoT). However, WSN encounters limitations related to energy and sensor node lifespan, making the development of an efficient routing protocol a critical concern. Cluster technology offers a promising solution to this challenge. This study introduces a novel cluster routing protocol for WSN. The system selects cluster heads and relay nodes utilizing the Multi-Strategy Fusion Snake Optimizer (MSSO) and employs the Minimum Spanning Tree algorithm for inter-cluster routing planning, thereby extending the system’s lifecycle and conserving network energy. In pursuit of an optimal clustering scheme, the paper also introduces tactics involving dynamic parameter updating, adaptive alpha mutation, and bi-directional search optimization within MSSO. These techniques significantly increase the algorithm convergence speed and expand the available search space.Furthermore, a novel efficient clustering routing model for WSN is presented. The model generates different objective functions for selecting cluster heads and relay nodes, considering factors such as location, energy, base station distance, intra-cluster compactness, inter-cluster separation, and other relevant criteria. When selecting cluster heads, the fuzzy C-means algorithm is integrated into MSSO to improve the optimization performance of the algorithm. When planning inter-cluster routing, the next hop node is selected for the relay node based on distance, residual energy, and direction.The experimental results demonstrate that the proposed protocol reduces energy consumption by at least 26.64% compared to other cluster routing protocols including LEACH, ESO, EEWC, GWO, and EECHS-ISSADE. Additionally, it increases the network lifetime of WSN by at least 25.84%, extends the stable period by at least 52.43%, and boosts the network throughput by at least 40.99%.
Outcomes of an innovative Sub-SMAS thread lifting for correction of mid-cheek groove
Authors: Huang Li-Wen , Dong Yun-Qing , Yang Yu , Li Shang-Yi , Yang Ching-Sheng , Hsu Hsin-Chien , Chang Kuang-Cheng
Published: February 2024

Background
The mid-cheek groove appearance is a common deficiency of the midface. This study described a novel deep plane thread lifting via the superficial muscular aponeurotic system (sub-SMAS) spaces incorporating with knit-circuit technique.
Methods
A total of 156 procedures were performed on 78 patients (5 men and 73 women, mean age of 43.21 ± 8.22 years old) in the study. Patients respectively underwent two rejuvenation procedures: (a) sub-SMAS plane thread lift and (b) supra-SMAS plane thread lift. Patients were followed up to 6 months. Clinical outcomes were evaluated using GAIS scores. Safety assessment was conducted for both types of thread –lifting procedures. Photographs were taken preoperatively and postoperatively for additional objective comparisons
Results
The patients of sub-SMAS group exhibited greater degree of improvement compare with that of supra-SMAS groups. The differences in GAIS score among groups significantly increased over time. Sub-SMAS group showed a lower GAIS score 6 months post-procedure than supra-SMAS (p < 0.01). Sub-SMAS was shown to have a longer lasting visible effect than supra-SMAS.
Conclusions
This deep plane thread lifting via the sub-SMAS spaces incorporating with knit-circuit technique is a safe procedure for correcting mid-cheek groove with favorable longevity.