bluuebunny/crossref_metadata_2025 huggingface dataset:
Phenazopyridine-Induced Methaemoglobinaemia - The Aftermath of Dysuria Treatment
Authors: Hamza Amina , Nasrullah Adeel , Singh Romil , DiSilvio Briana
Published: February 2022

Introduction: Phenazopyridine is an over-the-counter urinary analgesic commonly used to alleviate the burning and urgency associated with lower urinary tract infections. Methaemoglobinaemia is an uncommon adverse effect of phenazopyridine use. We report a case of methaemoglobinaemia in a patient prescribed daily phenazopyridine to treat urethral and bladder irritation caused by a chronic indwelling Foley catheter. Case description: A 55-year-old female resident of a long-term acute care facility with a chronic Foley, tracheostomy and ventilator-dependent respiratory failure was observed to have generalized dusky skin and hypoxia. Pulse oximetry was reading in the high 80s despite administration of 100% FiO2. ABG revealed paO2 of 451, oxyhaemoglobin level 75% and methaemoglobin level 22%. Medication review indicated that the patient was prescribed phenazopyridine 400 mg TID for the previous 2 months. This medication was discontinued. Considering she was chronically taking mirtazapine, she can increase risk of serotonin syndrome should she be administered first-line treatment with methylene blue. Vitamin C was thus instead administered as a second-line agent. Serial ABGs showed a rapid decline in methaemoglobin levels and an increase in oxyhaemoglobin within 2 days. Discussion: Acquired methaemoglobinaemia is a rare adverse effect of treatment with phenazopyridine. This risk increases when drug dosage and duration exceed manufacturer specifications. Treatment typically includes cessation of the offending drug and administration of methylene blue in severe cases. A thorough medication reconciliation should be performed prior to methylene blue initiation, as patients taking serotonergic medications (for example, MAOIs, SSRIs, SNRIs, TCAs) are at increased risk of serotonin toxicity with co-administration of methylene blue. In these instances, ascorbic acid/vitamin C can be chosen as an alternative treatment agent. Conclusion: Work-up of refractory hypoxia should involve a thorough review of medications as even some over-the-counter drugs can cause the fatal side effect of methaemoglobinaemia. Treatment with vitamin C should be considered over methylene blue if serotonergic medications have been recently prescribed in order to avoid risk of serotonin syndrome.
Analysis of broadband mid-infrared optical parametric amplification based on LiGaS2, LiGaSe2, LiInS2, and LiInSe2 crystals
Authors: Zhou Lu , Novák Ondřej , Smrž Martin , Mocek Tomáš
Published: February 2022

Optical parametric amplification (OPA) is a powerful technique for generating mid-IR ultrashort pulses. Determination of proper OPA conditions is based on the study of phase-matching curves. In this paper, we provide this study for

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non-oxide crystals in a type I arrangement. Phase-matching characteristics and gain spectra were calculated when pumped at wavelengths of 1.03, 1.064, 1.94, and 2.1 µm. By pumping few-millimeter-long Li-based crystals at

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pump intensity, the signal gain spectrum bandwidths from a few tens of nanometers to a few thousands of nanometers can be obtained. All these crystals can display a broad bandwidth signal amplification, allowing the generation of broadband mid-IR ultrashort pulses.
Observation of slow light in glide-symmetric photonic-crystal waveguides
Authors: Murendranath Patil Chirag , Arregui Guillermo , Mechlenborg Morten , Zhou Xiaoyan , Alaeian Hadiseh , David García Pedro , Stobbe Søren
Published: February 2022

We report optical transmission measurements on suspended silicon photonic-crystal waveguides, where one side of the photonic lattice is shifted by half a period along the waveguide axis. The combination of this glide symmetry and slow light leads to a strongly enhanced chiral light-matter interaction but the interplay between slow light and backscattering has not been investigated experimentally in such waveguides. We build photonic-crystal resonators consisting of glide-symmetric waveguides terminated by reflectors and use transmission measurements as well as evanescent coupling to map out the dispersion relation. We find excellent agreement with theory and measure group indices exceeding 90, implying significant potential for applications in slow-light devices and chiral quantum optics. By measuring resonators of different length, we assess the role of backscattering induced by fabrication imperfections and its intimate connection to the group index.
High-performance waveguide Ge/Si avalanche photodiode with a lateral separate-absorption-charge-multiplication structure
Authors: Xiang Yuluan , Cao Hengzhen , Liu Chaoyue , Dai Daoxin
Published: February 2022

A high-performance waveguide Ge/Si avalanche photodiode operating at the O-band (1310 nm) is designed with a Ge/Si ridge waveguide defined by two shallow trenches in the active region and fabricated with simplified processes. The device shows a high primary responsivity of 0.96 A/W at the unit-gain voltage of −7.5 V. It has a large 3-dB bandwidth of >27 GHz and a low dark current of 1.8 µA at a reverse bias voltage of −13 V. When the present Ge/Si APD is used for receiving 25 Gbps data, the eye-diagram is open even for an optical power as low as −18 dBm. Furthermore, 50 Gbps data receiving is also demonstrated with an input optical power of −15 dBm, showing the great potential of the present Ge/Si APD for the application in future high-speed data transmission systems.
Label-free imaging of intracellular organelle dynamics using flat-fielding quantitative phase contrast microscopy (FF-QPCM)
Authors: Ma Ying , Dai Taiqiang , Lei YunZe , Zheng Juanjuan , Liu Min , Sui Bingdong , Smith Zachary J. , Chu Kaiqin , Kong Liang , Gao Peng
Published: February 2022

Panoramic and long-term observation of nanosized organelle dynamics and interactions with high spatiotemporal resolution still hold great challenge for current imaging platforms. In this study, we propose a live-organelle imaging platform, where a flat-fielding quantitative phase contrast microscope (FF-QPCM) visualizes all the membrane-bound subcellular organelles, and an intermittent fluorescence channel assists in specific organelle identification. FF-QPCM features a high spatiotemporal resolution of 245 nm and 250 Hz and strong immunity against external disturbance. Thus, we could investigate several important dynamic processes of intracellular organelles from direct perspectives, including chromosome duplication in mitosis, mitochondrial fusion and fission, filaments, and vesicles’ morphologies in apoptosis. Of note, we have captured, for the first time, a new type of mitochondrial fission (entitled mitochondrial disintegration), the generation and fusion process of vesicle-like organelles, as well as the mitochondrial vacuolization during necrosis. All these results bring us new insights into spatiotemporal dynamics and interactions among organelles, and hence aid us in understanding the real behaviors and functional implications of the organelles in cellular activities.
Robust single-frequency 589 nm fiber laser based on phase modulation and passive demodulation
Authors: Cui Shuzhen , Zeng Xin , Jiang Huawei , Cheng Xin , Yang Xuezong , Zhou Jiaqi , Feng Yan
Published: February 2022

A robust 20-W continuous-wave single frequency 589 nm laser is developed to aim for sodium guide star in astronomy. The source is based on applying π-depth binary phase modulation to a single frequency seed laser along with 3 steps of strain in the gain fiber to suppress the stimulated Brillouin scattering in the high power 1178 nm amplifier and realizing the recovery of single frequency after frequency doubling in a periodically poled LiTaO3 crystal. The efficiency of frequency doubling reaches up to 41.6%. To the best of our knowledge, it is the highest power reported for continuous-wave 589 nm laser generation by single-pass frequency doubling. The approach significantly simplifies the sodium guide star laser design and improves robustness.
Compact substrate-removed thin-film lithium niobate electro-optic modulator featuring polarization-insensitive operation
Authors: Pan Ying , He Mingbo , Xu Mengyue , Lin Zhongjin , Lin Yanmei , Ke Wei , Liu Jie , Lin Zhenrui , Zhu Yuntao , Gao Shenqian , Li Hao , Liu Xiaoyue , Liu Chuan , Yu Siyuan , Cai Xinlun
Published: February 2022

A compact polarization-insensitive electro-optic (EO) modulator, which allows the laser and modulator to be located at different locations while using a standard single-mode fiber to interconnect them, is highly desirable for 5G or future 6G wireless networks. Herein, we propose a modulator based on substrate-removed thin-film lithium niobate. The proposed device exhibits a polarization-dependent loss of 0.35 dB and on-chip loss of approximately 2 dB. The polarization insensitivity of the proposed device was experimentally demonstrated using a four-level pulse-amplitude modulation format at 50 Gbaud (100 Gb/ s).
Room temperature continuous-wave operated 2.0-W GaN-based ultraviolet laser diodes
Authors: Yang Jing , Zhao De-Gang , Liu Zong-Shun , Wang Baibin , Zhang Yu-Heng , Zhang Zhen-Zhuo , Chen Ping , Liang Feng
Published: February 2022

Temperature characteristics of near-UV laser diodes (LDs) with a lasing wavelength of 384 nm are investigated. The characteristic temperature of threshold current (T0) of the UV LDs is low. Thus, the performance of the UV LDs under continuous wave (CW) operation is not as good as under pulsed operation especially at a high injection current. In addition, it is found that self-heating is a key factor for CW characteristics of the UV LDs, where suppression of the self-heating by using thick waveguide layers can increase the critical current of thermal rollover of the UV LD’s operation. A high CW output power of 2.0 W is achieved for an InGaN near-UV LD with the n-side down on a sub-mount, whose threshold current density is 1.27 kA/cm2 and the highest wall plug efficiency (WPE) is approximately 15.9% at an injection current of 1.2 A.
High efficiency and collimated terahertz pulse from ultra-short intense laser and cone target
Authors: Cai J. , Shou Y. R. , Han L. Q. , Huang R. X. , Wang Y. X. , Song Z. H. , Geng Y. X. , Yu J. Q. , Yan X. Q.
Published: February 2022

We propose a new, to the best of our knowledge, method to radiate a high-efficiency and collimated terahertz (THz) pulse from a relativistic femtosecond laser and cone target. Particle-in-cell simulations demonstrate that a THz source of 40 mJ, pointing at an angle of ∼20

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, can be generated from a laser pulse of 1.9 J by using a cone target whose open angle is 10

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. The peak power of the THz pulse is 1011 W. This method, which manipulates the divergence angle and the energy conversion efficiency of the THz source, should promote THz science into the extra strong region with a compact laser system.
Stability of Al and Ag metallic thin film mirrors in a space environment under the implantation of low energy helium ions
Authors: Singh Krishn Pal , Bhattacharjee Sudeep
Published: February 2022

The stability of aluminum (Al) and silver (Ag) metallic thin films (MTFs) under helium ion bombardment has been investigated in the laboratory to replicate the effect of alpha particle bombardment on spacecrafts and satellites in a space environment. The implanted helium ions have varying fluence and energies ranging from 0.5 - 3 keV. The helium ion fluence in the present study has been chosen according to 4 and 6 years journey of a solar orbiter. The reflectivity of Al and Ag MTFs is investigated over a wide range of electromagnetic radiation covering ultraviolet to near infrared (200 - 2500 nm), prior and post helium ion implantation. It is observed that the degradation in the reflectivity of the above-mentioned MTFs is reasonably low for helium ion implantation and no significant impact is observed on reflectivity of both (Al and Ag) MTFs in the investigation. This opens a channel of utilization of these MTFs to provide better protection for the optical components used in spacecrafts. Surface characterization such as surface roughness is carried out to investigate the surface morphology of MTFs prior and post implantation using atomic force microscopy (AFM). It is observed that the effect of implantation on surface morphology is in accordance with the experimental results of reflectivity. SRIM/TRIM simulations help to obtain the distribution profile and penetration depth of helium ions inside the Al and Ag MTFs.
The neglected epidemic—Risk factors associated with road traffic injuries in Mozambique: Results of the 2016 INCOMAS study
Authors: Peralta-Santos André , Gimbel Sarah , Sorensen Reed , Covele Alfredo , Kawakatsu Yoshito , Wagenaar Bradley H. , Augusto Orvalho , Ásbjörnsdóttir Kristjana Hrönn , Gloyd Stephen S. , Cuembelo Fatima , Sherr Kenneth ,   with input from the INCOMAS Study Team
Published: February 2022

In 2019, 93% of road traffic injury related mortality occurred in low- and middle-income countries, an estimated burden of 1.3 million deaths. This problem is growing; by 2030 road traffic injury will the seventh leading cause of death globally. This study both explores factors associated with RTIs in the central region of Mozambique, as well as pinpoints geographical “hotspots” of RTI incidence. A cross-sectional, population-level survey was carried out in two provinces (Sofala and Manica) of central Mozambique where, in addition to other variables, the number of road traffic injuries sustained by the household within the previous six months, was collected. Urbanicity, household ownership of a car or motorcycle, and socio-economic strata index were included in the analysis. We calculated the prevalence rate ratios using a generalized linear regression with a Poisson distribution, as well as the spatial prevalence rate ratio using an Integrated Nested Laplace Approximation. The survey included 3,038 households, with a mean of 6.29 (SD 0.06) individuals per household. The road traffic injury rate was 6.1% [95%CI 7.1%, 5.3%]. Urban residence was associated with a 47% decrease in rate of injury. Household motorbike ownership was associated with a 92% increase in the reported rate of road traffic injury. Higher socio-economic status households were associated with a 26% increase in the rate of road traffic injury. The rural and peri-urban areas near the “Beira corridor” (national road N6) have higher rates of road traffic injuries. In Mozambique, living in the rural areas near the “Beira corridor”, higher household socio-economic strata, and motorbike ownership are risk factors for road traffic injury.
Predicting age at onset of type 1 diabetes in children using regression, artificial neural network and Random Forest: A case study in Saudi Arabia
Authors: Alazwari Ahood , Abdollahian Mali , Tafakori Laleh , Johnstone Alice , Alshumrani Rahma A. , Alhelal Manal T. , Alsaheel Abdulhameed Y. , Almoosa Eman S. , Alkhaldi Aseel R.
Published: February 2022

The rising incidence of type 1 diabetes (T1D) among children is an increasing concern globally. A reliable estimate of the age at onset of T1D in children would facilitate intervention plans for medical practitioners to reduce the problems with delayed diagnosis of T1D. This paper has utilised Multiple Linear Regression (MLR), Artificial Neural Network (ANN) and Random Forest (RF) to model and predict the age at onset of T1D in children in Saudi Arabia (S.A.) which is ranked as the 7th for the highest number of T1D and 5th in the world for the incidence rate of T1D. De-identified data between (2010-2020) from three cities in S.A. were used to model and predict the age at onset of T1D. The best subset model selection criteria, coefficient of determination, and diagnostic tests were deployed to select the most significant variables. The efficacy of models for predicting the age at onset was assessed using multi-prediction accuracy measures. The average age at onset of T1D is 6.2 years and the most common age group for onset is (5-9) years. Most of the children in the sample (68%) are from urban areas of S.A., 75% were delivered after a full term pregnancy length and 31% were delivered through a cesarean section. The models of best fit were the MLR and RF models withR2= (0.85 and 0.95), the root mean square error = (0.25 and 0.15) and mean absolute error = (0.19 and 0.11) respectively for logarithm of age at onset. This study for the first time has utilised MLR, ANN and RF models to predict the age at onset of T1D in children in S.A. These models can effectively aid health care providers to monitor and create intervention strategies to reduce the impact of T1D in children in S.A.
Impact of physician’ and pharmacy staff supporting activities in usual care on patients’ statin adherence
Authors: Huiskes Victor Johan Bernard , Vriezekolk Johanna Everdina , van den Ende Cornelia Helena Maria , van Dijk Liset , van den Bemt Bartholomeus Johannes Fredericus
Published: February 2022

Aims

Little is known about usual care by physicians and pharmacy teams to support adherence to statins and whether the extent of this care is associated with adherence to statins. Objective of the study was to examine the relationship between the extent of adherence supporting activities of healthcare practitioners (HCPs) and patients’ adherence to statins.

Methods

Cross-sectional study in 48 pharmacies and affiliated physicians’ practices, between September 3, 2014 and March 20, 2015. Patients visiting the pharmacy with a statin prescription from participating prescribers were invited to participate. Usual care to support adherence was assessed among HCPs with the Quality of Standard Care questionnaire about usual care activities to support adherence. Adherence to statins was assessed among patients with the MARS-5 questionnaire. The association between the extent of HCPs’ adherence supporting activities and patients’ adherence was examined by means of multilevel regression analysis.

Results

1,504 patients and 692 HCPs (209 physicians, 118 pharmacists and 365 pharmacy technicians) participated. No association was found between the extent of physicians’ adherence supporting activities and patients’ adherence to statins. The extent of adherence supporting activities by pharmacy teams in usual care was negatively associated with patients’ adherence to statins (B coefficient -0.057 (95%CI: -0.112- -0.002).

Conclusions

This study suggests that there is no positive relationship between the extent of HCPs’ adherence supporting activities in usual care and patients’ adherence to statins. Other methods than questionnaires (e.g. electronic monitors (to assess adherence) and observations (to assess usual care) should be applied to confirm the results of this study.
The (cyclical) path towards impoliteness in electoral debates
Authors: Fernández García Francisco
Published: February 2022

This work proposes, first, an approach to the agonal character of electoral debates, and then analyses the nature of the acts of (im)politeness that appear in them. From there, it presents a triangular theoretical-methodological framework, based on the analysis of functional impoliteness strategies, linguistic-discursive mechanisms for their implementation and social repercussions of impolite acts. Within the first of these three axes, a dynamic quantitative analysis is carried out. This analysis demonstrates the growing appearance of impoliteness in electoral debates, as well as the cyclical nature of this growth ‒ which is increasingly accelerated ‒ in successive sections of these speech events. This quantitative analysis is based on the face-to-face debate between Mariano Rajoy and Alfredo Pérez Rubalcaba days before the Spanish general elections in November 2011.
Estilo comunicativo en el prólogo de Antígona: la interacción entre Antígona e Ismene
Authors: Conti Luz
Published: February 2022

El presente trabajo analiza el prólogo de Antígona a partir del concepto de estilo comunicativo. El análisis de las intervenciones de Antígona y de Ismene desde esta perspectiva permite describir una serie de estrategias sintácticas y pragmáticas que varían según avanza la interacción entre ellas. Aunque sus estilos comunicativos no se mantienen constantes, sí se observan determinados rasgos que caracterizan las intervenciones de una y otra hermana.
Forme dell’atto direttivo nel greco neotestamentario. Politeness, testualità e mutamento linguistico
Authors: Tronci Liana
Published: February 2022

Questo studio analizza le espressioni dell’atto direttivo nella lingua neotestamentaria, con particolare riferimento al tema della politeness e costituisce la prima tappa di una ricerca più ampia. I dati per questo lavoro sono tratti dal Vangelo di Matteo. La forma più tipica per l’espressione di atti direttivi in greco antico è l’imperativo flesso alla seconda persona. Strategie linguistiche che attenuano la forza dell’atto direttivo rendendolo più polite operano sia sul piano sintagmatico (uso di forme allocutive come κύριε ‘signore’; combinazione dell’imperativo con espressioni come εἰ βούλει ‘se vuoi’) sia su quello paradigmatico (forme verbali alternative alla seconda persona dell’imperativo: il futuro, da un lato, e la terza persona, dall’altro). Alcuni atti direttivi rivolti da Gesù ai suoi interlocutori potrebbero sembrare molto impolite, se considerati al di fuori del contesto di enunciazione. Il fatto che non lo siano getta una prospettiva nuova sia sull’analisi del testo evangelico sia nelle ricerche sulla politeness/impoliteness.
Politeness in early Ptolemaic papyri: a frame-based approach
Authors: Bruno Carla
Published: February 2022

This paper deals with the expression of linguistic politeness in early Hellenistic documentary papyri, through a data-oriented approach exploiting the notion of “frame” (cf. Terkourafi 2001), which accounts for politeness in terms of regular correlations between forms and contexts. The study focuses on a subset of epistolary types, i.e., ordinary business letters, recommendations and petitions, considering those situational and expressive features that make them distinct frames of interaction. Deviances from the frame of the petition within the corpus are then taken into account and evaluated in terms of impoliteness or rudeness.
Novedades onomásticas y sociales proporcionadas por cinco inscripciones emeritenses
Authors: Pérez Gutiérrez María Luisa
Published: February 2022

Se estudian en detalle cinco inscripciones inéditas o incompletamente estudiadas de Augusta Emerita, cuatro placas y un ara de mármol. La primera se conserva en el Museo Arqueológico Nacional de Madrid y las siguientes, en el Museo Arqueológico de Arte Romano de Mérida. Todas ellas aportan novedades onomásticas y sociales.
THE EFFECT OF PRECIPITATION ON MICROSTRUCTURE AND CORROSION BEHAVIOUR OF ZK60 SUBJECTED TO SEVERE PLASTIC DEFORMATION AS BIODEGRADABLE MATERIAL
Authors: Rifai Muhammad
Published: February 2022

Microstructure and corrosion behaviour of ZK60 subjected to severe plastic deformation (SPD) as biodegradable material has been investigated in terms of grain refinement process and precipitation formation. Equal channel angular pressing (ECAP) was one of the well-known SPD techniques due to their advantages to promote dislocation and grain fragmentation. ZK60 billet was cut to a 10 mm diameter cylindrical shape for biodegradable material application. ECAP process was carried out up to two passes by Route Bc at 423 K temperature process. Microhardness test was performed at ECAP processed sample, and the structure observation was carried by optical microscope and transmission electron microscope. The corrosion behaviour of the material was investigated by an anodic polarization curve. The ECAP process promotes dislocation accumulation efficiently and ultrafine-grained structure formation. It may improve the formability characteristic of ZK60. The hardness also showed significant increment during the ECAP process due to the high level of deformation. Corrosion behaviours and microstructure observation during the ECAP process showed a correlation that concluded that grain refinement and precipitation formation influenced the electrochemical properties. The alloying element such as Zn and Zr promoted the protective film for corrosion due to their ability for pitting protection. ECAP improved the precipitation formation for corrosion resistance, microstructure uniformity and material formability.
BIOKOROSI DAN TEKNOLOGI PENCEGAHANNYA DI INDUSTRI MINYAK DAN GAS
Authors: Royani Ahmad , Hanafi Muhammad , Julistiono Heddy , Manaf Azwar
Published: February 2022

Biokorosi atau Microbiologically Influenced Corrosion (MIC) adalah salah satu bentuk korosi lokal yang dihasilkan dari mikroorganisme dan aktivitasnya yang mempunyai dampak negatif pada fasilitas di industri minyak dan gas. Keberadaan mikroorganisme dan aktivitasnya yang kompleks memainkan peranan penting dalam pembentukan biofilm dan produk korosi yang menyebabkan kerusakan peralatan. Meskipun beberapa teknik mitigasi dan pencegahan dalam usaha pengendalian mikroorganisme telah dilakukan, tinjauan tentang mitigasi korosi yang dipengaruhi mikroorganisme masih terbatas. Dalam tinjauan ini, dibahas jenis mikroorganisme terkait biokorosi, pembentukan biofilm, teknik deteksi dan evaluasi mikroorganisme, teknologi pencegahan dan pengendalian mikroorganisme di industri minyak dan gas. Perkembangan teknologi terkini pengendalian mikroorganisme di industri lainnya juga turut dibahas.
FATIGUE FAILURE IN A LONGITUDINAL WELDED ELBOW OF A PROCESSING VESSEL
Authors: Adnyana D.N.
Published: February 2022

A longitudinal welded elbow made of austenitic stainless steel type 316 and used as a drain line on a processing vessel had suffered damage (leakage) after it had only been in operation for a few years. Process fluid that was drained out of the vessel consists of fatty acid containing hydrogen gas at a temperature of 150°C and a pressure of 60 bar(g). Initially, the drain process was carried out only once a year, but recently due to frequent changes in the types of product being made, the frequency of drain process has increased to several times a month. This study aims to determine the type and factors that have caused leakage in the elbow. Metallurgical assessment was carried out by preparing a number of specimens from the leaking elbow. A number of laboratory examinations were performed including visual and macroscopic tests, chemical composition analysis, metallographic examination, hardness tests and scanning electron microscopy (SEM) equipped with energy-dispersive spectroscopy (EDS) analysis. The results obtained indicate that the leaking elbow has experienced fatigue failure due to cyclic loadings caused by the increasing frequency of the number of drain processes carried out through the elbow. The factor causing fatigue failure at the elbow is likely due to welding defect of imperfect shape that formed on the inner wall of the elbow around the HAZ (heat-affected zone)/fusion boundary, and causing high stress concentrations in that area.
Az elődök szerepvállalása az utódlást követően a családi
gazdaságokban Karcagon
Authors: Kovács Éva Katalin
Published: February 2022

A legtöbb családi gazdaság a rendszerváltást követően jött létre, így az akkori alapítók többsége esetében a generációváltás kérdése aktuális témává vált. Az utódlás sikerességét számos tényező befolyásolja, többek között az utód hajlandósága az átvételre és az előd hajlandósága az átadásra. A gyakorlatban az tapasztalható, hogy az elődök többsége az utódlást követően is aktív szerepet tölt be a gazdaság életében. Néhány esetben azonban ez a túlzott ragaszkodás akadályozhatja az utódokat a fejlődésben. Ez hosszú távon akár motiválatlanná teheti az utódokat, amely veszélyeztetheti a családi gazdaságok jövőjét. Kutatásom során azt vizsgáltam, hogy a családi gazdaságokban hogyan alakul az elődök szerepvállalása Karcagon és erről az utódok hogyan vélekednek.
Are you there? Presence in collaborative distance work
Authors: Bauters Merja , Pejoska Jana , Durall Eva , Saarikivi Katri , Wikström Valtteri , Falcon Mari , Martikainen Silja
Published: February 2022

Already before the pandemic, digitally mediated collaborative work and communication were perceived as challenging. We investigate the attitudes towards emerging technologies and for transforming practises in workplaces. The focus lies on understanding the readiness for appropriating emotional tracking on presence and support for collaboration. The research-based design framework allowed to combine the various perspectives of the transdisciplinary team. Methods included participatory design, design thinking, contextual inquiry and prototype testing for enhancing presence while working with shared objects in video conferencing to explore the appropriation of tools. The findings revealed four indications: 1) awareness of interlocutors’ presence during synchronous communication is crucial. 2)  Emotion and behaviour tracking raises concerns about privacy and personal control over what is displayed to others, and technology could be simpler non-distracting the work at hand.  3) The prototype was found to enhance the feeling of presence without disturbing work at hand, and 4) appropriation requires a step-by-step approach.
Communio Dei and the Mind of Christ
Authors: Everhart D. T.
Published: February 2022

One view of theological anthropology that might benefit from engagement with psychological sciences is relational theological anthropology. Studies in social psychology show that humans develop personal identity through sharing in group identity. I will explore how human beings share mental states when participating in groups. This will be used to explain how Christians in the body of Christ come to share in the mind of Christ. In sharing in new identity in Christ, the community of God in the Church shares in the mind of Christ together. This new identity is shared between its members without eradicating the individual identity of each member.
Saberes, sabores y formas: entre lo sensorial y lo sensible en la investigación
Authors: Hernández González Edilberto , Ospina Álvarez Teresita , Zapata López Margarita María
Published: February 2022

Esta producción textual se ocupa de una experimentación-creación con alimentos en la que el cuerpo y la vida se abren caminos en ese espacio privado de la comida que (nos) despliega otras presencias. En esta experiencia los cuerpos se detienen, huelen, tocan, son tocados, sienten y se toman su tiempo para degustar. Afloró, entonces, una especie de necesidad de los alimentos de ser vividos, ellos nos toman para que pase algo con ellos y con nosotros, los investigadores. La experimentación se sustenta en la investigación-creación con artes, la misma que posibilitó delinear una imagen sensorial y sensible de la investigación.
Tejedoras GEA-R7: redes, territorios y nuevas miradas estéticas
Authors: Suárez Arteaga Mónica Cecilia , Assad Marín María Camila , Tamayo Castaño María Cristina
Published: February 2022

Este artículo tiene como objetivo dar a conocer al lector una estrategia de trabajo en red y formativa, que ha permitido la continuidad de dos colectivos en el tiempo, mediante la interacción con medios tecnológicos que superan la barrera del cuerpo. Para ello se pretende reconocer los conceptos fundamentales que dan forma a dicha interacción y son: el territorio, la sororidad y la configuración de red. Posteriormente, se dará un breve recuento de las organizaciones y la forma de trabajo, para al final relacionar algunas de las experiencias de los participantes de las organizaciones de GEA y R7, su sentir pensar, reconociendo sus voces sobre el trabajo con las organizaciones.
Absurdno (přel. B. Pořízková – D. Weinhold)
Authors: Nagel Thomas
Published: February 2022

Translation of the text written by Thomas Nagel.
MiR-145 on the Proliferation of Ovarian Cancer Cells by Regulating the Expression of MMP-2/MMP-9
Authors: Wang Mei , Zhang Shu
Published: February 2022

This study aimed to consider the effect of miR-145 on the proliferation of OC cells by regulating the expression of MMP-2/MMP-9. In this experiment, the miR-145 target gene with restriction enzyme cut sites was amplified from the four groups of rat genomes, and it was ligated to the pIRES plasmid to form a recombinant plasmid and identified. The miR-145 recombinant plasmid and the empty plasmid into OC cells were transfected, and qRT-PCR was used to detect the expression of miR-145 in the transfected OC cells. Experimental data showed that there are a total of 60 healthy male SD rats, randomly divided into 4 groups, namely the normal saline control group (group A), the model group ( group B), treatment group with 30 mg miR-145 (group C), and treatment group with 100mg miR -145 (group D). The experimental results showed that compared with group A, the expression of MMP-2 protein in rats in groups B, C, and D all increased to varying degrees on 7 days, 14 days, and 28 days, reaching the highest at 14 days. This study shows that miRNA-145 is under-expressed in OC cell lines, and miR-145 can significantly inhibit the proliferation and invasion of ovarian cells by regulating the expression of MMP-2/MMP-9.
Gene Expression of Antioxidant Metabolic Enzymes in Grape Extracts
Authors: Cai Huitian , Zhang Yi , Qiu Zhehan , Luo Peihuan
Published: February 2022

Fruit can use its structural characteristics to stabilize the excess electrons of free radicals and prevent cell aging, which is the main source of antioxidants supplementation. In the current study, the expression of antioxidant metabolic genes was evaluated in fruit extract. Seventy mice were divided into one control group and six experimental groups. Six experimental groups were fed 0.1g of grape extract daily for 3, 7, 10, 14, 21, 24 and 30 days, respectively. The antioxidant activity of fruit extract was tested by antioxidant metabolic enzyme gene expression in the liver and kidney of different experimental groups. The results showed that grape extract could effectively enhance SOD activity, LPL relative expression and FAS relative expression in mice liver tissue; grape extract could effectively increase SOD relative expression, TrxR2 relative expression and CAT relative expression in mice kidney tissue; grape extract could effectively reduce MDA activity in mice liver tissue, and increase and decrease the extent of MDA activity and the duration of feeding in mice. The proportion of fruit extracts showed that fruit extracts could effectively improve the antioxidant performance of the body.
LncRNA-MALAT 1 regulates cardiomyocyte scorching in diabetic cardiomyopathy by targeting NLRP3
Authors: Shi Chang , Wu Lifang , Li Ling
Published: February 2022

Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus, often leading to heart failure, arrhythmias and sudden death. Long-stranded non-coding RNA (LncRNA), an endogenous non-coding long-stranded RNA, is associated with diabetic cardiomyopathy. However, the mechanism of LncRNA regulation of cellular scorching in diabetic cardiomyopathy remains unclear. This study aimed to elucidate whether MALAT 1 affects cardiomyocyte scorching in DCM patients. Methods: Streptozotocin (STZ) at 35 mg/Kg was used to induce diabetes in rats. H9C2 cardiomyocytes and primary cardiomyocytes (PCM) were cultured at 5.5 and 50 mmol/L glucose, respectively. The expression levels of MALAT 1 and scorch death-related genes were detected by RT-PCR using plasmids to suppress or overexpress the related genes, respectively. Immunofluorescence, RT-PCR and Western blot were used to detect the extent of cell scorch death. RESULTS: MALAT 1 expression was elevated in diabetic and high glucose-induced cardiomyocytes and myocardial tissue from diabetic mice (p<0.001). Silencing of MALAT 1 alleviated cardiomyocyte scorch death by targeting NLRP3. Furthermore, silencing MALAT 1 reduced cell death and improved cardiac function and morphology. CONCLUSIONS: MALAT 1 is overexpressed in DCM and silencing MALAT 1 inhibits cell scorch death by affecting NLRP3 expression. We clarify for the first time that MALAT 1 may be a new therapeutic target for DCM.
Clinical effect of Xuebijing combined with thymosinα1 on patients with severe pneumonia complicated with sepsis and its effect on serum inflammatory factors
Authors: Chen Yan , Zhou Lijuan , Wang Jing , Gu Tianhao , Li Shuqing
Published: February 2022

This study aimed to research the clinical effect of Xuebijing combined with thymosin α1 on patients with severe pneumonia complicated with sepsis, and its effect on serum inflammatory factors. For this purpose, 81 cases of severe pneumonia complicated with sepsis were collected. All patients were given early treatments. 41 cases who received Xuebijing injection by intravenous drip were selected as the control group. 40 cases who were treated through subcutaneous injection of thymosin α1 based on Xuebijing injection by intravenous drip were selected as the study group. The body temperature, respiration, heart rate, leukocytes, other general conditions, blood gas indexes, serum IL-6, TNF-α and CRP levels, bacterial clearance rate and therapy effect were recorded and compared before and after treatment. Results showed that after treatment, the body temperature, respiration, heart rate, leukocytes and other general conditions of the study group were lower than those in the control group (all p<0.05). The blood gas indexes pH and PaCO2 levels of the study group were lower than those of the control group. The levels of serum interleukin-6 (IL-6), serum tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) in the study group were lower than those in the control group (all p<0.05). The bacterial clearance rate of the study group was lower than that of the control group (all p<0.05). The total effective rate of treatment of patients in the study group was higher than that of patients in the control group (all p<0.05). In general, Thymosin α1 and Xuebijing injection can improve the therapy effect of severe pneumonia complicated with sepsis, improve the hemorheology condition of patients, effectively remove bacteria and reduce the expression level of serum CRP, TNF-α, IL-6, IL-8 and other inflammatory factors in patients, which is worthy of clinical promotion.
The Expression of MDM2 Gene Promoted Chondrocyte Proliferation in Rats with Osteoarthritis via the Wnt/β-Catenin Pathway
Authors: Jiang Jiahao , Feng Shuaihua , Li Zexiang , Luo Yangqian , Wang Zhenyuan , Li Mingyang , Wu Guanbao
Published: February 2022

This study aimed to investigate the regulatory mechanism of MDM2 gene expression on cartilage cell proliferation in Osteoarthritis (OA) rats. For this purpose, 22 SD rats were randomly divided into normal control (10 cases) and treated (12 cases) groups. Treated group was used for OA modelling with the modified Hulth method. After a week, RT-PCR was used to detect MDM2 in cartilage tissue of rats, Wnt 1, Wnt 3 a, Wnt 10 b and β-catenin genes mRNA expression. Rat chondrocytes were isolated and cultured, and the recombinant eukaryotic expression vector pcDNA3.1 myc-siRNA-MDM2-β-catenin and co-expression plasmid pcDNA3.1 myc-siRNA-MDM2-β-catenin was used to transfect chondrocytes and the proliferation and related gene expression levels of the transfected chondrocytes were detected by MTT method and RT-PCR. The results showed that compared with the control group, MDM2, Wnt 1, Wnt 3 a, Wnt 10b and β-catenin genes in OA rat cartilage constructed by Hulth method were increased (p<0.05). The pcDNA3.1 myc-beta-catenin transfection slowed down the proliferation of OA chondrocytes, different from the non-transfected OA group (p<0.001), and increased Wnt 1, Wnt 3a, Wnt 10b and β-catenin genes expression compared with the Control group (p<0.05), but did not affect the expression of MDM2. The transfection of siRNA-MDM2 was opposite to pcDNA3.1 myc-β-catenin. The co-expression plasmid pcDNA3.1 myc-siRNA-MDM2-beta-catenin transfection did not affect the proliferation of OA chondrocytes. In general, the high expression of MDM2 in OA rats restricts the proliferation of chondrocytes, which may be related to the main pathogenesis of the occurrence and development of OA in vivo, and the regulation of MDM2 on the proliferation of chondrocytes may be achieved through the Wnt/ β-catenin pathway.
The effect of fenofibrate, a peroxisome proliferator-activated receptor α agonist, on cardiac damage from sepsis in BALB/c mice
Authors: Lv Mingyi , Xie Dengmei , Long Xiaofeng
Published: February 2022

Cardiac dysfunction can be a fatal consequence of sepsis and lead to increased inflammatory responses or reduced fatty acid oxidation and final ATP depletion. Fenofibrate, which is an agonist of peroxisome proliferator-activated receptor α, has been used primarily in hypercholesterolemia and mixed dyslipidemia. Recent studies found that fenofibrate could alleviate energy metabolism and inflammation caused by cardiac damage during sepsis, and thus it had been paid great attention. This study was to investigate the possible protective roles of fenofibrate against cardiac damage in septic BALB/c mice. Methods: Forty male BALB/c mice aged 8 weeks old were divided randomly into four groups: control group; fenofibrate group; cecal ligation and puncture (CLP) group; and fenofibrate + CLP group. After administering fenofibrate or saline for 2 weeks, CLP was performed. Cardiac tissue and plasma were obtained 48 hours later. Plasma Troponin-T (Tnt), ATP, ADP and reactive oxygen species (ROS) levels were determined. PPARα and 53 protein levels were detected using western blotting. IL-6 and tumor necrosis factor-α (TNFα) were also assayed. We found that fenofibrate decreased plasma cTnT, ROS and increased the ratio of ATP/ADP. The elevations of IL-6, TNFα and P53 induced by sepsis were significantly suppressed by fenofibrate. Our results suggest that fenofibrate can regulate energy metabolism efficiently, which makes it a possible agent for treating sepsis-induced cardiac damage.
The Value of Comprehensive Nursing Intervention on Anxiety in Patients with Acute Heart Failure and Diabetes via Expression of Stress-related Genes
Authors: Xia Yingjie , Zhou Wenhua , Wu Siyu
Published: February 2022

Many patients with acute heart failure and diabetes experience varying degrees of anxiety upon entering the cardiac intensive care unit, which has adverse effects on the recovery process of these patients. Anxiety syndrome in these patients increases the risk of death up to three times. This study aimed to determine the effect of comprehensive nursing intervention on anxiety in patients with acute heart failure and diabetes by evaluating the expression of stress-related genes, i.e. COMT and BDNF genes. In this clinical trial study, 74 patients with acute heart failure and diabetes hospitalized in the cardiac intensive care unit were selected by convenience sampling method and randomly assigned to intervention and control groups. The control group received routine ward care, and the intervention group received nursing support program-based interventions in three informational, emotional, and physical dimensions in addition to regular care. Beck Anxiety Inventory was completed before and after the intervention in both groups. The expression of COMT and BDNF genes was evaluated by the qRT-PCR technique. Data were analyzed by Mann-Whitney U and independent T-test in SPSS software version 16. Before the intervention, no significant difference was observed between patients' anxiety scores in the intervention and control groups (p = 0.162). While, after the intervention, the anxiety score of the intervention group was lower than the control group (p = 0.02). The expression of COMT gene results showed that this gene expression was no statistical difference between the control group and intervention group, before intervention (p = 0.83). But, after the intervention, the expression of this gene was statistically decreased in the intervention group in comparison with the control group (p = 0.006). The BDNF gene expression results demonstrated that there was no difference between the two groups, before intervention (p = 0.46). After intervention, statistical increase was observed in control group (p = 0.042) and intervention group (p = 0.007). According to the results of this study, the comprehensive nursing intervention reduced patients' anxiety in the intervention group compared to the control group. This result was also confirmed by evaluating the expression of stress-related genes. Therefore, it is suggested that this intervention method be used to reduce anxiety in these patients.
Regulation of Cell Signaling Pathways by Genistein in Different Cancers: Progress, Prospects and Pitfalls
Authors: Mobeen Iqra , Romero Mirna Azalea , Yulaevna Ishmuratova Margarita , Attar Rukset , Jabeen Saima , Fayyaz Sundas
Published: February 2022

On the translational front, integrative genomic approaches have spurred the identification of diverse mechanisms of drug resistance, tumor heterogeneity, metastasis and emerging preclinical targets. Recent breakthroughs in oncogenic cell signaling pathways have forged new links and multi-disciplinary researchers have unraveled different facets of signaling landscapes. Natural product research has witnessed breakneck developments mainly in the context of the ever-expanding list of bioactive components having significantly pharmacological properties. Genistein has gradually gained appreciation because of its multifaceted roles in the prevention and inhibition of carcinogenesis and metastasis. More importantly, the entry of genistein into various phases of clinical trials substantiates the medicinal and pharmacological significance of genistein in cancer chemoprevention. In this review, we have attempted to summarize how genistein regulated different oncogenic pathways in carcinogenesis and metastasis. Furthermore, genistein-mediated regulation of non-coding RNAs is also an interesting feature that has been included in this review to realistically analyze how genistein-mediated control of miRNAs, lncRNAs and circRNAs influence carcinogenesis. In the later sections, we have provided a summary of clinical trials related to genistein for cancer prevention/inhibition. However, apart from the optimistic approaches to further investigate genistein-mediated cancer-inhibitory effects, certain hints have emerged which underscore the pro-metastatic role of genistein. Therefore, the pro-metastatic role of genistein in different cancers should be rationally tested in a broader context because these properties in the future may reduce the enthusiasm in the quest to pursue genistein as a potent cancer chemopreventive agent.