bluuebunny/crossref_metadata_2025 huggingface dataset:
Representation Learning of Biological Concepts: A Systematic Review
Authors: Yang Yuntao , Zuo Xu , Das Avisha , Xu Hua , Zheng Wenjin
Published: June 2023

Objective:

Representation learning in the context of biological concepts involves acquiring
their numerical representations through various sources of biological information, such as sequences,
interactions, and literature. This study has conducted a comprehensive systematic review by analyzing
both quantitative and qualitative data to provide an overview of this field.

Methods:

Our systematic review involved searching for articles on the representation learning of biological
concepts in PubMed and EMBASE databases. Among the 507 articles published between 2015
and 2022, we carefully screened and selected 65 papers for inclusion. We then developed a structured
workflow that involved identifying relevant biological concepts and data types, reviewing various representation
learning techniques, and evaluating downstream applications for assessing the quality of the
learned representations.

Results:

The primary focus of this review was on the development of numerical representations for
gene/DNA/RNA entities. We have found Word2Vec to be the most commonly used method for biological
representation learning. Moreover, several studies are increasingly utilizing state-of-the-art large
language models to learn numerical representations of biological concepts. We also observed that representations
learned from specific sources were typically used for single downstream applications that
were relevant to the source.

Conclusion:

Existing methods for biological representation learning are primarily focused on learning
representations from a single data type, with the output being fed into predictive models for downstream
applications. Although there have been some studies that have explored the use of multiple data types to
improve the performance of learned representations, such research is still relatively scarce. In this systematic
review, we have provided a summary of the data types, models, and downstream applications
used in this task.
Characteristics of LiFePo4 and Li-Ion Batteries during the Process of Charging and Discharging for Recommendation Solar Power Energy Storage
Authors: Khairunnisa Khairunnisa , Mafturoh Siti Mita
Published: June 2023

One of the advantages of using electric vehicle batteries to store electrical energy is an appropriate technology that supports zero emission. Hence, this research tries to compare based on each type of Lithium to be seen in terms of capacity and total energy obtained during charging and discharging conditions. The results of the comparison of the characteristics of the two batteries show that Lithium Iron Phosphate batteries have better quality. Based on the results of testing the conditions when charging from both of them, it was found that the capacity of the LiFePo4 battery was 22.93Ah while the Li-Ion was 2.65 Ah. for a total LiFePo4 energy of 79.84 Wh and Li-Ion of 10.28 Wh. Meanwhile, when testing the Discharging conditions, the LiFePo4 battery capacity based on the test results was 22.76 Ah and Li-Ion 2.60 Ah. Meanwhile, the measured total energy from LiFePo4 is 69.45 Wh, and Li-Ion is 9.44 Wh. Hence, if viewed from the advantages and disadvantages, Lithium Iron Phosphate batteries are suitable for accumulators or electric car batteries and energy storage for solar power plants
Patient Engagement in a Multimodal Digital Phenotyping Study of Opioid Use Disorder
Authors: Campbell Cynthia I , Chen Ching-Hua , Adams Sara R , Asyyed Asma , Athale Ninad R , Does Monique B , Hassanpour Saeed , Hichborn Emily , Jackson-Morris Melanie , Jacobson Nicholas C , Jones Heather K , Kotz David , Lambert-Harris Chantal A , Li Zhiguo , McLeman Bethany , Mishra Varun , Stanger Catherine , Subramaniam Geetha , Wu Weiyi , Zegers Christopher , Marsch Lisa A
Published: June 2023

Background

Multiple digital data sources can capture moment-to-moment information to advance a robust understanding of opioid use disorder (OUD) behavior, ultimately creating a digital phenotype for each patient. This information can lead to individualized interventions to improve treatment for OUD.

Objective

The aim is to examine patient engagement with multiple digital phenotyping methods among patients receiving buprenorphine medication for OUD.

Methods

The study enrolled 65 patients receiving buprenorphine for OUD between June 2020 and January 2021 from 4 addiction medicine programs in an integrated health care delivery system in Northern California. Ecological momentary assessment (EMA), sensor data, and social media data were collected by smartphone, smartwatch, and social media platforms over a 12-week period. Primary engagement outcomes were meeting measures of minimum phone carry (≥8 hours per day) and watch wear (≥18 hours per day) criteria, EMA response rates, social media consent rate, and data sparsity. Descriptive analyses, bivariate, and trend tests were performed.

Results

The participants’ average age was 37 years, 47% of them were female, and 71% of them were White. On average, participants met phone carrying criteria on 94% of study days, met watch wearing criteria on 74% of days, and wore the watch to sleep on 77% of days. The mean EMA response rate was 70%, declining from 83% to 56% from week 1 to week 12. Among participants with social media accounts, 88% of them consented to providing data; of them, 55% of Facebook, 54% of Instagram, and 57% of Twitter participants provided data. The amount of social media data available varied widely across participants. No differences by age, sex, race, or ethnicity were observed for any outcomes.

Conclusions

To our knowledge, this is the first study to capture these 3 digital data sources in this clinical population. Our findings demonstrate that patients receiving buprenorphine treatment for OUD had generally high engagement with multiple digital phenotyping data sources, but this was more limited for the social media data.

International Registered Report Identifier (IRRID)

RR2-10.3389/fpsyt.2022.871916
Use of Biofeedback-Based Virtual Reality in Pediatric Perioperative and Postoperative Settings: Observational Study (Preprint)
Authors: Orgil Zandantsetseg , Karthic Anitra , Bell Nora F , Heisterberg Lisa M , Williams Sara E , Ding Lili , Kashikar-Zuck Susmita , King Christopher D , Olbrecht Vanessa A
Published: June 2023

BACKGROUND

Biofeedback-based virtual reality (VR-BF) is a novel, nonpharmacologic method for teaching patients how to control their breathing, which in turn increases heart rate variability (HRV) and may reduce pain. Unlike traditional forms of biofeedback, VR-BF is delivered through a gamified virtual reality environment, increasing the accessibility of biofeedback. This is the first study to systematically integrate VR-BF use in the pediatric perioperative setting, with the ultimate goal of evaluating the efficacy of VR-BF to reduce pain, anxiety, and opioid consumption once feasibility and acceptability have been established.

OBJECTIVE

The primary objective was to develop a clinical trial protocol for VR-BF use in the pediatric perioperative setting, including preoperative education and training, and postoperative application of VR-BF in children undergoing surgery. A secondary objective was to evaluate the patient and parent experience with VR-BF.

METHODS

A total of 23 patients (12-18 years of age) scheduled for surgery at Nationwide Children’s Hospital were recruited using purposive sampling. Following training, participants independently completed a daily, 10-minute VR-BF session for 7 days before surgery and during their inpatient stay. Participants could use VR-BF up to 2 weeks after hospital discharge. Patient- and session-level data of VR-BF usage and achievement of target HRV parameters were measured to identify the optimal frequency and duration of sessions before and after surgery for this population. Standardized questionnaires and semistructured interviews were conducted to obtain qualitative information about patients’ experiences with VR-BF.

RESULTS

Patient-level data indicated that the highest odds of achieving 1 session under target HRV parameters was after 4 sessions (odds ratio [OR] 5.1 for 4 vs 3 sessions, 95% CI 1.3-20.6; OR 16.6 for 3 vs 2 sessions, 95% CI 1.2-217.0). Session-level data showed that a session duration of 9 to 10 minutes provided the greatest odds of achieving 1 session under target HRV parameters (OR 1.3 for 9 vs 8 min, 95% CI 1.1-1.7; OR 1.4 for 8 vs 7 min, 95% CI 1.1-1.8; OR 1 for 10 vs 9 min, 95% CI 0.9-1.2). Qualitative data revealed patient satisfaction with the VR-BF technology, particularly in managing perioperative stress (17/20, 85%). Few patients reported VR-BF as beneficial for pain (8/20, 40%).

CONCLUSIONS

Children and adolescents undergoing surgery successfully learned behavioral strategies with VR-BF with 10-minute sessions once daily for 5 days. To integrate VR-BF as a therapeutic intervention in a subsequent clinical trial, patients will be instructed to complete three 10-minute sessions a day for 7 days after surgery.

CLINICALTRIAL

ClinicalTrials NCT04943874; https://clinicaltrials.gov/ct2/show/NCT04943874
Impact of information sharing on Actual Purchase intention on TikTok among women in

Malaysia: Based on Technology affordance (Preprint)
Authors: DAN HE , Nazmi Sannusi Shahrul , Ahmad Rizal Ammar Redza Bin
Published: June 2023

BACKGROUND

With the increased prevalence of social media usage, Malaysian female consumers hugely rely
on reviews and information on TikTok. This application's popularity is enhancing, making it a
critical technique for many businesses to grow and reach the target audience. For this reason,
their purchase intention also depends on the knowledge received through TikTok about any
product in the form of advertisements, reviews, etc.

OBJECTIVE

H1: Modality in social media positively impacts sharing of information.
H2: Agency in social media positively impacts the sharing of information.
H3: Interactivity positively impacts the sharing of information.
H4: Navigation in social media sites positively impacts the sharing of information.
H5: Guidance shopping positively impacts the sharing of information.
H6: Sharing of information positively impacts the purchase intention.
H7. Purchase intention significantly impacts the actual purchase of consumers.

METHODS

The present study has applied a quantitative
research design to investigate the phenomenon. Female consumers in Malaysia were approached
for data collection. 500 questionnaires were distributed among them, out of which 432 were
received as complete and adequate response sheets.

RESULTS

Data were analyzed through SPSS and
AMOS. Results indicated a significant association between NAV and IS, IS and PI, and PI and
AP.

CONCLUSIONS

The research holds numerous theoretical and practical significance as it extends the literature
related to the technological impact on purchase intentions and the growth of businesses. The
practical insights of the study lie in the information it conveys to Malaysian marketing or
advertising agencies to divert their focus from traditional mediums of promotion towards TikTok
advertisements and influencer marketing.
A Large Language Model Screening Tool to Target Patients for Best Practice Alerts: Development and Validation (Preprint)
Authors: Savage Thomas , Wang John , Shieh Lisa
Published: June 2023

BACKGROUND

Best Practice Alerts (BPAs) are alert messages to physicians in the electronic health record that are used to encourage appropriate use of health care resources. While these alerts are helpful in both improving care and reducing costs, BPAs are often broadly applied nonselectively across entire patient populations. The development of large language models (LLMs) provides an opportunity to selectively identify patients for BPAs.

OBJECTIVE

In this paper, we present an example case where an LLM screening tool is used to select patients appropriate for a BPA encouraging the prescription of deep vein thrombosis (DVT) anticoagulation prophylaxis. The artificial intelligence (AI) screening tool was developed to identify patients experiencing acute bleeding and exclude them from receiving a DVT prophylaxis BPA.

METHODS

Our AI screening tool used a BioMed-RoBERTa (Robustly Optimized Bidirectional Encoder Representations from Transformers Pretraining Approach; AllenAI) model to perform classification of physician notes, identifying patients without active bleeding and thus appropriate for a thromboembolism prophylaxis BPA. The BioMed-RoBERTa model was fine-tuned using 500 history and physical notes of patients from the MIMIC-III (Medical Information Mart for Intensive Care) database who were not prescribed anticoagulation. A development set of 300 MIMIC patient notes was used to determine the model’s hyperparameters, and a separate test set of 300 patient notes was used to evaluate the screening tool.

RESULTS

Our MIMIC-III test set population of 300 patients included 72 patients with bleeding (ie, were not appropriate for a DVT prophylaxis BPA) and 228 without bleeding who were appropriate for a DVT prophylaxis BPA. The AI screening tool achieved impressive accuracy with a precision-recall area under the curve of 0.82 (95% CI 0.75-0.89) and a receiver operator curve area under the curve of 0.89 (95% CI 0.84-0.94). The screening tool reduced the number of patients who would trigger an alert by 20% (240 instead of 300 alerts) and increased alert applicability by 14.8% (218 [90.8%] positive alerts from 240 total alerts instead of 228 [76%] positive alerts from 300 total alerts), compared to nonselectively sending alerts for all patients.

CONCLUSIONS

These results show a proof of concept on how language models can be used as a screening tool for BPAs. We provide an example AI screening tool that uses a HIPAA (Health Insurance Portability and Accountability Act)–compliant BioMed-RoBERTa model deployed with minimal computing power. Larger models (eg, Generative Pre-trained Transformers–3, Generative Pre-trained Transformers–4, and Pathways Language Model) will exhibit superior performance but require data use agreements to be HIPAA compliant. We anticipate LLMs to revolutionize quality improvement in hospital medicine.
Ориентализм в геополитических представлениях военных и дипломатических элит Российской империи (на материалах обсуждения «армянского вопроса» в конце XIX – начале XX в.)
Authors:   North-Caucasus Federal University (1, Pushkin St., 355017 Stavropol, Russian Federation), Ambartsumyan Karine R.
Published: June 2023

Introduction. Edward W. Said’s Orientalism: Western Conceptions of the Orient introduced the category ‘Orientalism’ into scientific and political discourse. So, the article focuses on the Armenian question that became a remarkable part of the Eastern question at the turn of the 20th century — to illustrate features of ‘Russian Orientalism’. The decline of the Ottoman Porte, difficulties faced by ethnic Armenians in Turkey, and the political unrest among Armenians of the Caucasus resulted in that the Russian military and diplomats were paying close attention to those events, which was reflected in related reports. Materials and methods. The published sources examined are those authored by N. Ivanov, A. Nelidov, D. Putyata, P. Tomilov, I. Vorontsov-Dashkov, R. Termen. The archival documents involved (State Archive of Russian Federation) are A. Nelidov’s reports of 1882 and 1896, both addressed to V. Lamsdorf. The theoretical basis is shaped by concepts of Orientalism, Occidentalism, and critical geopolitics, the latter viewing geopolitical ideas of elites as an independent phenomenon referred to as ‘high geopolitics’. Results. After the Treaty of Berlin (1878) the Armenian question became a new domain for interaction between the great powers. The analysis conducted herein confirms that ‘Russian Orientalism’ — in geopolitical ideas of the elites — had an anti-Western shade. Paradoxically, in Eastern contexts Russian imperial elites were positioning themselves as representatives of European civilization. However, when it came to defend national interests, their reasoning would obtain anti-Western tones. Occidentalism presupposes a unification of the Western world, which, for example, can be observed in the reports of Ya. Lundekvist and A. Nelidov. The views and shades of Orientalism were determined by practical job tasks. For instance, Governor-General I. Vorontsov-Dashkov was rather a bearer of ‘internal Orientalism’ suggesting a patronizing concern for the Caucasian Armenians. Therefore, there were certain differences in attitudes of capital-based executives and those articulated by ones in the colonized periphery of the Empire. Conclusions. So, the study concludes as follows. Firstly, how the elites tended to perceive the essence of the Armenian question and its Turkish contexts proves the legitimacy of the category ‘Russian Orientalism’ — directed both outside and inside — the latter covering the Caucasus with a certain portion of Armenian population. Secondly, features of Orientalism in geopolitical representations of Russian elites were determined by practical tasks of their service. Thirdly, ‘Russian Orientalism’ is more heterogeneous and its aspects outnumber those presented in Edward W. Said’s study.
Благопожелание чаю в калмыцкой лирике ХХ в.: фольк­лорный аспект
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Khaninova Rimma M.
Published: June 2023

Introduction. In Kalmyk folklore, the genre of tea well-wishes (Kalm. цәәд тәвх йѳрәл) accompanies many rituals characterized by magic poetry and aimed to secure health, longevity, well-being, human happiness, as well as preservation and prosperity of the surrounding world. Tea is a major meal component to be offered to the spirits of ancestors, deities, and individuals for the fulfillment of well-wishes. In Kalmyk traditional meals, tea remains a basic element. The article is topical enough since tea well-wishes in 20th-century Kalmyk poetry are still somewhat understudied. Goals. The study seeks to identify related examples in terms of genre, consider the folklore tradition and innovations, analyze available Russian translations for adequacy. Materials and methods. The article focuses on representative Kalmyk- and Russian-language (including Russian translations) poems by Kalmyk poets addressed to tea. Methodology rests on historical-literary and comparative approaches to reveal the relation between folklore and poetry, the continuity of this genre throughout Kalmykia’s literary process. Results. The paper attests to the bulk of poetic tea well-wishes — in the folklore aspect — underwent some changes and were created in the mid-to-late 20th century. Conclusions. Tea well-wishes in writings of Kalmyk poets are characterized by genre syntheses, certain plots, inclusions of proverbs and sayings, folklore formulas, praises to the beverage, descriptions of how it be cooked, and its leading role in the ethnic meals model.
Влияние режимов лазерной обработки чугунов на параметры зон упрочнения и их триботехнические свой­ства
Authors: Бирюков В.П.
Published: June 2023

Представлены результаты металлографических и триботехнических испытаний чугунов в парах трения со сталью 40Х. Показано, что использование поперечных колебаний лазерного луча при обработке значительно повышает ее производительность, исключает возникновение поверхностных дефектов, возникающих при воздействии излучения расфокусированным лучом на поверхность образцов из чугунов. Установлено, что лазерное термическое упрочнение в зависимости от режимов обработки значительно снижает коэффициенты трения и повышает микротвердость в 4–6 раз и износостойкость модифицированных поверхностей чугунов в 2,5–3,5 раза по сравнению с их исходным состоянием.
Конструкционные материалы для обеспечения электромагнитной совместимости радиоаппаратуры
Authors: Гришин Д. , Гусев И.
Published: June 2023

Электромагнитное экранирование – ​широко распространенный метод обеспечения электромагнитной совместимости (ЭМС) радиоаппаратуры. Эффективность экранирования и надежность функционирования аппаратуры во многом определяются конструкцией экранов, а также характеристиками и свой­ствами материалов, используемых для их изготовления. В статье рассмотрены основные конструкционные материалы, применяемые для электромагнитного экранирования, такие как прокладки, контактные пружины, ткани, термоусадочные трубки, поглотители ВЧ-излучения с клеевым слоем. Описана методика подтверждения характеристик экранирующих материалов в лаборатории ЭМС АО «ТЕСТПРИБОР».
Análisis cualitativo por categorías a priori: reducción de datos para estudios gerenciales
Authors: Rueda Sánchez Mónica Patricia , Armas Wilmer José , Sigala-Paparella Sigala-Paparella
Published: June 2023

El análisis de datos por categorías en una investigación cualitativa requiere tres fases interrelacionadas: reducción de datos, análisis descriptivo y la interpretación. La reducción permite resumir los datos recogidos y facilitar su posterior entendimiento. Para ello, se requiere categorizar, codificar, registrar y tabular. En tal sentido, el objetivo de este estudio es describir el proceso seguido para cumplir con estos aspectos en el desarrollo de un estudio de caso en las ciencias administrativas y gerenciales. Para ejemplificar la aplicación de la categorización se utiliza una investigación sobre capacidades dinámicas en una empresa del sector de bebidas alcohólicas en Venezuela. No se pretende explicar los resultados de la investigación, si no exponer el proceso seguido en la reducción de datos de un análisis cualitativo por categorías. Se mostró la elaboración de un plan de códigos para realizar el registro en un esquema de codificación por categorías. Además, se confeccionó la tabulación con el fin de condensar, organizar y evidenciar las carac terísticas y relaciones de la información proporcionada por los informantes claves. Se concluye que la reducción de datos para el análisis cualitativo por categorías requiere definir categorías y subcategorías para la investigación; elaborar un plan de códigos; transcribir las entrevistas y asignar números de líneas a cada copia; y elaborar matrices descriptivas por cada subcategoría.
Analytical Comparison of Conventional Slab and Voided Slab Using Ansys 14.5 – A Review
Authors: Athare Shubham , Bhalerao A. U.
Published: June 2023

Abstract: Reinforced concrete slab with plastic voids is a new and innovative type of structural, concrete slab system developed to allow for lighter self weight of thestructure while maintaining similar load carrying capacity of a solid slab. In this study the design process for plastic voided slab is compared with reinforced concrete solid flat slab through a design comparison of typical bays with the same thickness. Also, the finite element analysis of the slab panels has been carried out byusing ANSYS Workbench 14.5 to find out the deformation. The primary objective of the work is to obtain optimum slab system with the above stated parameters. Also, the finite element analysis of the slab panels has been carried out byusing ANSYS Workbench 14.5 to find out the deformation. The primary objective of the work is to obtain optimum slab system with the above stated parameters.
Pengaruh Rekrutmen, Kompetensi dan Pengembangan Karir Terhadap Kinerja Karyawan
Authors: Sari Ni Ketut Devina , Astina Made Arya , Praminatih Gusti Ayu
Published: June 2023

Tujuan dalam penelitian ini adalah unrtuk mengetahui pengaruh rekrutmen , komptetensi dan pengembangan karir terhadap kinerja karyawan di Hotel Bali Mandira Beach Resort & Spa Legian. Penelitian ini dilakukan di Bali Mandira Beach Resort & SPA Legian, yaitu pada bulan Februari sampai dengan Juni 2021. Jenis penelitan adalah penelitian korelasional. Metode analisis data yang digunakan dalam penelitian ini adalah regresi linear berganda yang digunakan untuk mengetahui pengaruh Rekrutmen, Kompetensi dan Pengembangan Karir Terhadap Kinerja. Sampel digunakan sebanyak 40 orang karyawan dengan teknik sampling jenuh. Pengujian hipotesis penelitian menggunakan SPSS 25.0. Hasil penelitian ini menunjukkan Rekrutmen, Kompetensi dan pengembangan karir berpengaruh sangat signifikan (p<0,01) secara parsial terhadap Kinerja Karyawan Kemudian, Rekrutmen, Kompetensi dan Pengembangan karir berpengaruh sangat signifikan (p<0,01) secara simultan terhadap Kinerja Karyawan.
 
Employees who are skilled in serving hotel guests according to their competence will improve the quality of service and performance of a hotel as a whole. This research was conducted at Bali Mandira Beach Resort & SPA Legian, from February to June 2021. The data analysis method used in this study was multiple linear regression which was used to determine the effect of Recruitment, Competence and Career Development on Performance by distributing questionnaires to The sample of 40 employees used as a saturated sampling technique. Testing the research hypothesis using SPSS 25.0. The results of this study indicate that recruitment, competence and career development have a very significant effect partially on employee performance, getting results of 0.000 < 0.01. Then, Recruitment, Competence and Development have a very significant effect simultaneously on Employee Performance getting the results 0.000 <0.001. It can be concluded that the results show that recruitment, competence and employee development affect employee performance. Employees can produce quality work that either matches or exceeds the standards set by the company.
Why We Should Not Wait for Existing Latvian Crowdfunding Platforms’ Authorisation under the EU Regulation on Crowdfunding Service Providers for Business
Authors:   University of Latvia, Adlere Oksana
Published: June 2023

The past decade, the crowdfunding market was growing rapidly in the European Union, including Latvia. At the same time, crowdfunding had remained unregulated domain until the European Union Regulation on European crowdfunding service providers for business (henceforth - the Regulation) was passed in October, 2020, giving the Member States one year for its adoption, and additional one year for crowdfunding service providers for authorising under the Regulation. Nevertheless, by the end of 2022, there was only one licensed crowdfunding service provider managed by Latvian legal entity. Considering this, the goal of the study is to explore why the majority of existing crowdfunding platforms, managed by legal entities registered in Latvia, has not authorised itself under the Regulation. To achieve the goal, the methodology of the study combines in-depth analysis of the Regulation with an explanatory case study of crowdfunding platforms managed by Latvian legal entities. Having considered nine platforms managed by Latvian legal entities, the results of the study show that four biggest Latvian platforms have authorized themselves as investment firms. Among other platforms which are unlicensed for the time being, there could be only one potential candidate to extend the list of crowdfunding service providers authorised under the Regulation. The conclusion was made considering the business models of the providers, and presence or absence of an auto-investing function, which was restricted by the Regulation. An implication of the obtained results is the possibility that the research will serve as a base for future studies on the Regulation’s effect on the European crowdfunding industry.
Evaluation of Left Ventricular Function in Patients with Mitral Annular Disjunction Using Speckle Tracking Echocardiography
Authors: Dogan Omer , Ozyildirim Serhan , Guven Baris , Yumuk Mehmet Tugay , Barman Hasan , Topel Cagdas , Atıcı Adem , Donmez Ayça , Kucukoglu Serdar , dogan sait m.
Published: June 2023

Introduction: Mitral annular disjunction (MAD) is a structural
abnormality characterized by the systolic detachment of the posterior
mitral annulus and the ventricular myocardium. It is usually observed
coexistent with mitral valve prolapse(MVP) and associated with a
mechanical dysfunction despite preserved electrical isolation function
of the mitral annulus. Diagnosis depends on the detection of disjunction
by imaging modalities as transthoracic echocardiography or cardiac
magnetic resonance imaging (CMRI). This study aimed to evaluate left
ventricular (LV) function using speckle tracking echocardiography in MVP
patients with MAD. Methods: This study was designed as a
prospective, single-center study including 103 patients with MVP and 40
age- and sex-matched control subjects. Transthoracic echocardiography
and cardiac magnetic resonance imaging were performed to assess LV
function and MAD presence. Results: MAD (+) MVP (n=34), MAD (-)
MVP (n=69), and control (n=40) groups were enrolled in the study. Among
the MVP patients, 34 (33%) had MAD. T negativity in the inferior leads
on electrocardiography was more frequent in the MAD (+) group than in
the MAD (-) patients (4.3% vs 20.6%, p=0.014). Mitral regurgitation
degree, Pickelhaube sign (17.6% vs. 1.4%, p=0.005), and late
gadolinium enhancement frequency (35.3% vs. 10.6%, p=0.002) were
significantly higher in MAD (+) patients. MAD (+) patients had
significantly impaired global longitudinal strain (GLS) -23.1±2.1 vs.
-23.5±2.3, P<0.001), basal longitudinal strain (BLS)
(-19.6±1.5 vs -20.5±1.9, P < 0.001), and Mid-Ventricular
Longitudinal Strain(MVLS) (-22.2±1.7 vs -23.2±2.2, P<0.001)
when compared to MAD (-) MVP patients, despite similar LV ejection
fraction. All these values of MVP patients were also significantly lower
than the control group. The mean MAD distance was 7.8 ± 3.2 mm in MAD
(+) patients. Patients with 2 or more symptoms were higher in the MAD
(+) group than in the MAD (-) group (4.3% vs 44.1%,
P<0.001). Conclusion: This study demonstrated a
significant decrease in longitudinal strain in MVP patients with MAD,
indicating myocardial dysfunction. These findings suggest that MAD may
contribute to LV dysfunction and highlight the importance of early
detection in younger patients. Further research is needed to explore the
functional implications and long-term outcomes of MAD.
Patterns of Alluviation in Mixed Bedrock-Alluvial Channels: 1. Numerical Model
Authors: Cho Jongseok , Nelson Peter A.
Published: June 2023

Mixed bedrock-alluvial rivers can exhibit partial alluvial cover, which
may play an important role in controlling bedrock erosion rates and
landscape evolution. However, numerical morphodynamic models generally
are unable to predict the pattern of alluviation in these channels.
Hence we present a new two-dimensional depth-averaged morphodynamic
model that can be applied to both fully alluvial and mixed
bedrock-alluvial channels, and we use the model to gain insight into the
mechanisms responsible for the development of sediment patches and
patterns of bedrock alluviation. The model computes hydrodynamics,
sediment transport, and bed evolution, using a roughness partitioning
that accounts for differential roughness of sediment and bedrock,
roughness due to sediment transport, and form drag. The model
successfully replicates observations of bar development and migration
from a fully alluvial flume experiment, and it models persistent
sediment patches observed in a mixed bedrock-alluvial flume experiment.
Numerical experiments in which the form drag, sediment transport
roughness, and ripple factor correction were neglected did not
successfully reproduce the observed persistent sediment cover in the
mixed bedrock-alluvial case, suggesting that accounting for these
different roughness components is critical to successfully model
sediment dynamics in bedrock channels.
A multi-chemistry modelling framework to enable flexible and reproducible water quality simulations in existing hydro-models: 2. The OpenWQ-SUMMA and OpenWQ-CRHM model implementations and testing.
Authors: Costa Diogo , Klenk Kyle , Knoben Wouter Johannes Maria , Ireson Andrew , Spiteri Raymond J , Clark Martyn P.
Published: June 2023

This work advances the cross-model deployment of ecological and
biogeochemical simulation capabilities in existing process-based
hydro-modeling tools, which we term “Open Water Quality” (OpenWQ). The
companion paper details aspects of the OpenWQ architecture that enables
its plug-in type incorporation into existing models, along with its
innovative aspects that enable biogeochemistry lab-like capabilities.
OpenWQ’s innovative aspects allow modelers to define the pollution
problem(s) of interest, the appropriate complexity of the
biogeochemistry routines, test different modeling hypotheses, and deploy
them across different hydro-models. In this second paper, we implemented
the coupling recipe described in the first paper to integrate OpenWQ
into two hydro-models, SUMMA and CRHM. Here we explain how the
implemented coupling interface between the two models provides water
quality simulation capacities in the host hydro-models but, more
importantly, establishes a direct and permanent link for the transfer of
innovation between the modeling communities. Example applications of
different pollution studies enabled by our coupling recipe are also
provided to address some of these fundamental water quality modeling
challenges.
Covalently bound lipids in reconstructed human epithelia
Authors: Ponec M , Boelsma E , Weerheim A.
Published: June 2023

The composition of free and covalently bound lipids in reconstructed epithelia generated with normal human keratinocytes, HaCaT cells and squamous carcinoma cells was investigated and compared with native skin. Stratum corneum isolated from native human and reconstructed epidermis was subjected to extensive extraction with chloroform-methanol mixtures followed by alkaline hydrolysis to release covalently bound lipids. High-performance thin layer chromatography was used for analysis of solvent-extractable and non-extractable lipids and gas liquid chromatography was performed to assess the fatty acid profile in extractable lipids. In both native and reconstructed tissue covalently bound lipids consisted of omega-hydroxyceramides, omega-hydroxyacids and free fatty acids. Small amounts of omega-hydroxyacids could already be detected in solvent-extractable fractions. omega-Hydroxyceramides consisted of Ceramide A, Ceramide B and a small fraction of unknown ceramides with intermediate polarity. The relative proportions of individual omega-hydroxyceramides were similar in both native and reconstructed stratum corneum. In contrast, differences were found in profiles of both solvent-extractable and non-extractable lipids isolated from epithelia reconstructed with transformed cell lines (HaCaT, SCC-12F2 and SCC-13 cells). Compared with native or reconstructed epidermis, in epithelia reconstructed with transformed cell lines the ceramide content was low, the most polar ceramides were missing and the content of free fatty acids was low. The same holds true for covalently bound lipids that were virtually absent in these epithelia. Marked similarities were demonstrated in the overall lipid composition of free and bound stratum corneum lipids in native epidermis and in epidermis reconstructed with normal human keratinocytes. The observed imbalance in fatty acid profile may account for differences in phase behaviour of stratum corneum lipids.
Record linkage as a vital key player for the COVID-19 syndemic -- The call for legal harmonization to overcome research challenges
Authors: Doetsch Julia Nadine , Kajantie Eero , Dias Vasco , Indredavik Marit S. , Devold Randi Kallar , Teixeira Raquel , Reittu Jarkko , Barros Henrique
Published: June 2023

Key messages:

Chronicity and social context influence COVID-19 risk highlighting its syndemic dimension
Record Linkage advances knowledge on COVID-19, associated chronic diseases, and social indicators
Further harmonization of data protection requirements for scientific research may create multilevel public health measures
As a multidimensional tool, it optimizes integrated strategies and fosters solidarity on Health in All Policies (HiAP)
Modelo para la concientización ambiental basado en la contextualización en la educación medio superior
Authors: Monroy Carreño Roberto , Domínguez Pacheco Flavio Arturo
Published: June 2023

La concientización ambiental es un inherente al pensar en mejorar la situación medioambiental, por ende, es necesario incorporar sectores que cuentan con conocimientos que pueden ser aprovechados para desarrollar integralmente al individuo en relación con su entorno. Trayendo consigo pensar en el sistema educativo para este fin, teniendo como objetivos principales, relacionar los distintos tipos de conocimiento con necesidades presentes en la vida cotidiana del estudiante, de tal manera que pueda ir dinámica y gradualmente concientizando el impacto de su actuar en el ambiente.

Para lo anterior se utilizó el modelo para la concientización ambiental basado en la contextualización, fundamentada en las fases de la concientización ambiental por las que transita una persona, los componentes de la educación ambiental, los seis niveles para poder formar las habilidades necesarias para cimentar el pensamiento crítico y el modelo ERCA.  Esta investigación es una etapa de un proceso heurístico, teniendo su primera implementación en la Escuela Nacional Colegio de Ciencias y Humanidades Plantel Vallejo, en una población total de 240 y 452 alumnos para el periodo 2021 y 2022 respectivamente, correspondientes a estudiantes de la materia de Física.  Obteniendo con su implementación materiales basados en el modelo constructivista y la taxonomía de Bloom que son la esencia de la institución, pero correlacionando los aprendizajes con situaciones contextualizadas. Logrando con ello una disminución del 20% en el índice de reprobación de la asignatura de Física, una reducción promedia mínima del 2.15% del consumo energético domiciliario, y un incremento en la participación en eventos científicos.
The Development of Financial Obligation Assistance in Inter-State Relations Regarding Environmental Protection: a Review of The Paris Agreement 2015
Authors: Zuhaida Azka , Alkazahfa Asry M.
Published: June 2023

Abstract

The increasing global environmental issues affect how countries view international environmental policy. This insists countries carry out joint international responsibility on environmental law issues which later developed as Common but Differentiated Responsibility and Respective Capabilities principle (Principle of CDR-RC). The implementation of the principle should be seen as the aspect of financial assistance from developed countries to developing countries in the Paris Agreement 2015. This research aims to determine the development of the relation-interaction of the financial assistance between developed countries and developing countries in the context of international environmental law, especially regarding climate change issues as well as the obligation and financial mechanism in the Paris Agreement 2015. The result shows a development of universal responsibility into a shared international responsibility in overcoming climate change issues. Several different principles in each international instrument affect relation-interaction and financial assistance. Furthermore, the financial assistance is regulated in detail in Article 9 of the Paris Agreement 2015 with financial mechanisms referred to the United Nations Framework Convention on Climate Change (UNFCCC).

Keywords: financial assistance, developed and developing countries, Paris Agreement 2015
The Hanafi School of Islamic Jurisprudence Literature: A Historical Account
Authors: Suud Sarim Karimullah  , Arif Sugitanata
Published: June 2023

This article focuses on one of the founding figures of the Sunni school of Islamic jurisprudence who contributed to the development of Islamic law, Abū Hanifah. Studying Abū Hanifah's literature can better understand his thoughts and views on Islamic legal issues. It can also provide greater insight into the history of Islamic thought and how Abū Hanifah's thoughts impact Muslim society today. This study uses the heuristic method with critical literature analysis because the data is obtained from various books, journals, and other documentation relevant to the historical approach. The results of this study state that the Hanafi school of Islamic jurisprudence is one of the famous schools of Islamic jurisprudence in the scientific discipline of Islamic law founded by Abū Hanifah. His background and education strongly influence Abū Hanifah's thinking pattern in determining the law. It is also inseparable from the socio-cultural dimension and the politics that underlie the Hanafi school of Islamic jurisprudence, which is seen as a factor affecting Islamic law's rational character. Literature on studying Islamic law in the Hanafi school of Islamic jurisprudence is widely found and spread worldwide. The school of Islamic jurisprudence is even adopted by one-third of the world's Muslim population. However, remember that some of Abū Hanifah's written works may no longer be available or incomplete. Over time, some manuscripts may be damaged or lost.
Random Forests Algorithm for Two Levels of Coral Reef Ecosystem Mapping Using Planetscope Image in Malalayang Beach, Manado
Authors: Cera Fela Pritian , Danoedoro Projo , Wicaksono Pramaditya , Yasir Moh
Published: June 2023

The coral reef ecosystem has a significant physical and biological function and is also one of the coastal ecosystem components apart from the seagrass and mangrove ecosystem. Besides their ecological function, the coral reef also has an economic function. The condition of the coral reef ecosystem in Malalayang Beach has been changing for years. The utilization of remote sensing images can monitor current conditions. This research aims to map the coral reef ecosystem mapping in Malalayang Beach, Manado and conduct a test for the accuracy of coral reef ecosystem mapping using field survey data as a classification and validation sample. PlanetScope multispectral image has four channels to detect underwater objects: red, green, blue and near infrared. PlanetScope level 3B image for the research has a surface reflectance value for its pixel. The image processing stages of this research consist of sunglint correction, water column correction, and then continue to classify the coral reef ecosystem using random forests algorithm. Classification and accuracy training sample data were obtained using the photo transect technique. The sunglint correction regression equation is between 0.27 â€“ 0.38. The coefficient of attenuation ratio in B1 is 0.927797938, B2 is 0.168841585, and B3 is 0.29033029. This value then becomes the input for the Lyzenga formula. The classification accuracy for level one using random forests is 72,54%, and the accuracy for level two mapping is 37,61%.Keywords: Coral Reef Ecosystem, Planetscope, Random Forests
ACADEMIC MOBILITY: EUROPEAN AND ORIENTAL VECTORS OF COOPERATION
Authors: Popova Oleksandra
Published: June 2023

The article deals with the issues related to the international academic mobility. Some key notions within the academic sphere have been specified (academic mobility, academic integration, academic normative documents). The author outlines the European and Oriental vectors of academic cooperation (involvement of the academic staff and students into the programmes of international advanced training and / or internship; joint participation in scientific grant programmes; international co-supervision of Bachelor, Master, PhD research).
STUDY ON DIRECTED MOTIVATIONAL CURRENTS
IN SPOKEN ENGLISH LEARNING
Authors: Liangyan Li
Published: June 2023

Based on the theory of Directed Motivational Currents, this study conducted a diachronic investigation on non-English majors with a case study approach and analyzes the development and changes of their motivation of oral English learning．The results show that the motivational dimensions such as goals or visions, facilitative structure and positive emotionality can significantly promote oral English learning. In college oral English teaching, stimulating, maintaining and protecting students’ directed motivational currents can help to improve the quality of oral English teaching and students’ learning efficiency.
THE OVERSEAS DISSEMINATION AND RECEPTION OF THE TRANSLATION OF THE QUOTATIONS OF MAO ZEDONG: BASED ON AMAZON READER REVIEWS
Authors: Pengrong Zhang , Shizhaoyun Shuai
Published: June 2023

For a long time, as the main object of foreign translation and dissemination of Chinese books, The Quotations of Mao Zedong has had a remarkable impact on China and the world. The comments and evaluations of foreign readers are an important aspect to study and measure the effectiveness of the work’s foreign translation and distribution. In this paper, with the help of data crawler tool and text mining tool ROST CM6, a quantitative and qualitative study on the reader reviews of the translation of The Quotations of Mao Zedong on Amazon platform is conducted. The trends of star ratings, emotional attitudes and number of reviews show that most readers have positive attitudes toward it, and give it positive evaluations. Readers’ motivation for reading is based not only on circulation but also on personal interests such as historical, philosophical or study needs; at the same time, its political ideology is another important reason. Although there are flaws in the quality of book design and the language quality of the translation, the overseas dissemination of the translation of The Quotations of Mao Zedong is on the rise and the overall acceptance is good.
An Investigation into the Impact of the Preferential Purchase Policy for Designated Vocational Rehabilitation Centers' Products on Performance and Regional Differences
Authors:   Korean Society of vocational Rehabilitation, Shin Hyun-Uk
Published: June 2023

This study utilized 2020 data on the operation of Vocational Rehabilitation Centers (VRCs) to assess their current state, examine the impact of the Preferential Purchase Policy (PPP) on their performance, and analyze regional disparities among VRCs that are designated for PPP. By using the QGIS program, this study found statistically significant disparity in the regional distribution of VRCs that are designated for products made by people with severe disabilities (PWSD), with the top 20% of VRCs accounting for nearly 80% of total sales. Furthermore, this study concluded that the PPP for PWSD-made products is a significant factor in enhancing the job performance and sales outcomes of VRCs. Based on the findings, the study recommends the following strategies for the development and operation of the PPP and VRCs: increasing the production of products made by PWSD and raising the preferential purchase rate to ensure consistent positive effects across all VRCs; implementing an evaluation system that incentivizes the purchase of products made by PWSD in the performance assessments of national institutions and public corporations; developing specialized strategies for VRCs in regions with a low ratio of preferential purchase from designated centers compared to other cities and provinces, including analyzing their capabilities and competitive factors and suggesting alternatives; and assessing the local government's willingness to support these centers and monitoring their performance. To improve the system and reduce the concentration of sales and resources in VRCs, it is crucial to systematically examine the causes of inequality. An effective resource allocation strategy should be established to allow the top 20% of facilities to share their expertise and resources to benefit the remaining VRCs. In addition, the roles of the Korea Association of Vocational Rehabilitation Facilities for the Disabled and Korea Disabled People's Development Institute should be strengthened to establish a coordination and monitoring system.