bluuebunny/crossref_metadata_2025 huggingface dataset:
TRBP, a Major Component of the RNAi Machinery, Is Subjected to Cell Cycle-dependent Regulation in Human Cancer Cells of Diverse Tissue Origin
Authors: Theotoki Eleni I. , Kakoulidis Panos , Velentzas Athanassios D. , Nikolakopoulos Konstantinos-Stylianos , Angelis Nikolaos V. , Tsitsilonis Ourania E. , Anastasiadou Ema , Stravopodis Dimitrios J.
Published: October 2024

Transactivation Response Element RNA-binding Protein (TRBP) is a double-stranded RNA-binding protein widely known for its critical contribution to RNA interference (RNAi), a conserved mechanism of gene-expression regulation mediated through small non-coding RNA moieties (ncRNAs). Nevertheless, TRBP has proved to be also involved in other molecular pathways and biological processes, such as cell growth, organism development, spermatogenesis and stress response. Mutations or aberrant expression of TRBP have been previously associated with diverse human pathologies, including Alzheimer’s disease, Cardiomyopathy and Cancer, with TRBP playing essential role(s) in proliferation, invasion and metastasis of tumor cells. Hence, the present study aims to investigate new, still elusive, functions and properties of TRBP, particularly regarding its cell cycle-dependent regulation during cancer-cell division. Our results unveil, for the first time, the tight and remarkable, mitosis-dependent, control of TRBP protein expression, as clearly evidenced by the lack of its immunofluorescence-facilitated detection, during mitotic phases, in several human cancer-cell lines of different tissue origin. Notably, the obtained TRBP-downregulation patterns seem to derive from molecular mechanisms that act independently of oncogenic activities (e.g., malignancy grade), metastatic capacities (e.g., low versus high) and mutational signatures (e.g., p53-/- or p53ΔΥ126) of cancer cells. Taken together, we, herein, propose that TRBP serves as a novel cell cycle-dependent regulator, likely exerting mitosis-suppression functions, and, thus, its mitosis-specific downregulation can hold strong promise to be exploited for the efficient and successful prognosis, diagnosis and (radio-/chemo-)therapy of diverse human malignancies, in the clinic.
Exploring the Link Between Malignant Melanoma and Urological Cancers: A Path Towards Personalized Medicine. Review of the Literature
Authors: Porav-Hodade Daniel , Todea-Moga Ciprian , Badea Mihail-Alexandru , Cotoi Ovidiu Simion , Vartolomei Mihai Dorin , Toganel Cornelia , Toganel Cornelia , Feciche Bogdan Ovidiu
Published: October 2024

Malignant melanoma and urological cancers originate from different tissues and organs, yet several studies highlight connections between these malignancies, including common risk factors, genetic predispositions, and immunological pathways. Research indicates that individuals with a history of melanoma have an elevated risk of developing renal cell carcinoma (RCC), while those with RCC are more likely to develop melanoma. Shared factors such as a personal or family history of cancer, UV radiation exposure, smoking, and obesity have all been linked to an increased incidence of various cancer types. A major link between malignant melanoma and urological cancers is the presence of shared genetic mutations and familial cancer syndromes. Key mutations, including germline mutations in BRCA1, MITF, CDKN2A, TP53, and alterations in the PI3K/AKT pathway, significantly contribute to the risk of both types of malignancies. Personalized medicine, which tailors prevention and treatment strategies to an individual’s genetic, environmental, and lifestyle factors, has significantly improved cancer care. The primary aim is to select the most effective treatment for each patient, maximizing therapeutic outcomes, reducing side effects, and minimizing the risk of drug resistance. Advances in genomics and immunology are driving the development of personalized therapies that target specific molecular pathways and immune responses common to both melanoma and urological cancers. Angiogenesis inhibitors and checkpoint inhibitors have demonstrated notable success in treating these cancers, with tumor mutational burden serving as a valuable biomarker for predicting the efficacy of immune checkpoint inhibitors.
Challenges of the QWERTY Keyboard for Quechua Speakers in the Puno Region in Perú
Authors: Juarez Vargas Henry , Mansilla Huanacuni Roger Mijael , Torres Cruz Fred
Published: October 2024

The widespread adoption of the QWERTY keyboard layout, designed primarily for English, presents significant challenges for speakers of indigenous languages such as Quechua, particularly in the Puno region of Peru. This research examines the extent to which the QWERTY layout affects the writing and digital communication of Quechua speakers. Through an analysis of the Quechua language’s unique alphabet and character frequency, combined with insights from local speakers, we identify the limitations imposed by the QWERTY system on the efficient digital transcription of Quechua. The study further proposes alternative keyboard layouts, including optimizations of QWERTY and DVORAK, designed to enhance typing efficiency and reduce the digital divide for Quechua speakers. Our findings underscore the need for localized technological solutions to preserve linguistic diversity while improving digital literacy for indigenous communities. The proposed modifications offer a pathway toward more inclusive digital tools that respect and accommodate linguistic diversity.
Global Assessment of Mesoscale Eddies with TOEddies; Comparison between Multi-Datasets and Colocation with In-Situ Measurements
Authors: Ioannou Artemis , Guez Lionel , Laxenaire Remi , Speich Sabrina
Published: October 2024

The present study investigates the general characteristics of mesoscale eddies in the Global Ocean, as identified and tracked by the TOEddies algorithm (Laxenaire et al., 2018) implemented on a global scale. Applied to satellite observations (AVISO/DUACS) of Absolute Dynamic Topography (ADT), TOEddies provides daily information on eddy dynamical characteristics (e.g., size and intensity) over a 30-year period (1993-2023) and identifies complex eddy-eddy interactions that lead to eddy splitting and merging. By capturing the multiple merging and splitting events that a single eddy can undergo, TOEddies generates a complex network of eddies that challenges the conventional view of a single trajectory associated with a single eddy. Furthermore, it offers an original assessment of interconnected eddy trajectories. A statistical description of the average characteristics of the eddies and their spatial distributions (generation, disappearance and merging/dividing is first provided. A comparative analysis of existing global eddy datasets is then presented. Among the years of observations, several coherent, long-lived mesoscale eddies with lifetimes exceeding 1.5 years stand out. However, we find that only a small fraction of these eddies is comparable between datasets, while their dynamic properties can differ substantially. Furthermore, the detection of eddies from altimetry is combined with 23 years of Argo profile co-localised measurements (2000-2023), allowing us to further investigate their contribution to the global subsurface ocean.
How Noise-Induced Hearing Loss Affects Hypertension: Pathophysiology and Prevention
Authors: Scheper Verena , Lenarz Thomas , Stavrakis Stavros , Förster Carola
Published: October 2024

More than 5% of the global population suffers from disabling hearing loss, primarily sensorineural hearing loss (SNHL). SNHL is often caused by factors such as vascular disorders, viral infections, ototoxic drugs, systemic inflammation, age-related labyrinthine membrane degeneration, and noise-induced hearing loss (NIHL). NIHL, in particular, leads to changes in blood-labyrinth-barrier (BLB) physiology, increased permeability, and various cardiovascular health issues, including hypertension, diabetes, neurological disorders, and adverse reproductive outcomes: Research has connected an elevated risk of hypertension with loud noise. The endocrine and autonomic nervous systems are also linked to arousal following an acute exposure to loud sounds. As a preventive option for both NIHL and hypertension as sequela of noise trauma, we present the transcutaneous vagus nerve stimulation (taVNS). taVNS may be appropriate to prevent NIHL-associated hypertension, as it typically reduces blood pressure and improves heart rate variability. On the other hand, normalizing cerebral blood flow preserves cochlear homeostasis, which is maintained by the BLB.The paper provides a comprehensive overview of NIHL pathophysiology and the impact of noise on auditory structures and function. Our research focuses on the auditory structures and functions affected by noise, such as the strial BLB, as well as the autonomic changes caused by NIHL, specifically the emergence of NIHL-associated hypertension as a primary comorbidity. We describe the clear link between taVNS use and increased HRV and slower progression of chronic hypertension, and we propose it as a cutting-edge preventive option for both conditions.
Reconstructing Intersection Conflict Zone: Microsimulation-Based Analysis of Traffic Safety for Pedestrians
Authors: Ištoka Otković Irena , Deluka-Tibljaš Aleksandra , Zečević Đuro , Šimunović Mirjana
Published: October 2024

According to statistics from the World Health Organization traffic accidents are one of the leading causes of death among children and young people, and the statistical indicators are even worse for the population of elderly pedestrians. Preventive measures and a significant increase in pedestrian safety require a comprehensive approach that includes analysis of traffic infrastructure and regulations, as well as the behavior and interaction between road users. In this paper, a methodology based on traffic microsimulations was developed for selecting the optimal reconstruction solution of urban traffic infrastructure from the aspect of traffic safety. Comprehensive analyses of local traffic conditions at the location – infrastructural and those related to traffic users was proposed. Developed methodology was applied and tested at a selected unsignalized pedestrian crosswalk in the urban traffic network of the city of Osijek, Croatia. It enabled analyzes of possible solutions for improving the traffic safety for vulnerable pedestrian groups, taking into account the specificities of the chosen location in the residential area and traffic participants behavior measured at the filed. Through database analysis, parameters influencing the reaction time and crossing time of children and elderly pedestrians in conflict zones were identified. Using microsimulation traffic modeling (VISSIM) and statistical tools, an analysis was conducted on the incoming vehicle speeds for both the existing and reconstructed conflict zone solutions under different traffic conditions. The developed methodology allowed the selection of the optimal solution from the perspective of traffic safety, considering the actual and future traffic conditions of the location for all traffic users.
Aviation-BERT-NER: Named Entity Recognition for Aviation Safety Reports
Authors: Chandra Chetan , Ojima Yuga , Bendarkar Mayank V. , Mavris Dimitri N.
Published: October 2024

This work introduces Aviation-BERT-NER, a Named Entity Recognition (NER) system tailored for aviation safety reports, building on the Aviation-BERT base model developed at the Georgia Institute of Technology's Aerospace Systems Design Laboratory. Unlike general NER models, this system integrates aviation domain-specific data, including aircraft types, manufacturers, quantities, and aviation terminology, to enhance its precision in identifying and classifying named entities critical for aviation safety analysis. A key innovation of Aviation-BERT-NER is its template-based approach to fine-tuning, which utilizes structured datasets to generate synthetic training data that mirrors the complexity of real-world aviation safety reports. This method significantly improves the model's generalizability and adaptability, enabling rapid updates and customization to meet evolving domain-specific requirements. The development process involved careful data preparation, including the synthesis of entity types and the generation of labeled datasets through template filling. Fine-tuning of the Aviation-BERT model demonstrated strong performance in precision, recall, and F1 scores, showing its efficacy in accurately identifying a wide range of entity types within aviation safety reports. Testing on real-world narratives from the National Transportation Safety Board (NTSB) database highlighted the model's robustness, with performance metrics indicating its potential to significantly enhance the automation of aviation safety report analysis. This work addresses a critical gap in English language NER models for aviation safety and establishes a new benchmark for domain-specific NER systems, promising substantial improvements in the analysis and understanding of aviation safety reports.
Quantum-Inspired Data Embedding for Unlabeled Data in Sparse Environments: A Theoretical Framework for Improved Semi-Supervised Learning without Hardware Dependence
Authors: Ray Shawn
Published: October 2024

This paper introduces an innovative theoretical framework for quantum-inspired data embeddings, grounded in foundational concepts of quantum mechanics such as superposition and entanglement. This approach aims to advance semi-supervised learning in contexts characterized by limited labeled data by enabling more intricate and expressive embeddings that capture the underlying structure of the data effectively. Grounded in foundational quantum mechanics concepts such as superposition and entanglement, this approach redefines data representation by enabling more intricate and expressive embeddings. Emulating quantum superposition encodes each data point as a probabilistic amalgamation of multiple feature states, facilitating a richer, multidimensional representation of underlying structures and patterns. Additionally, quantum-inspired entanglement mechanisms are harnessed to model intricate dependencies between labeled and unlabeled data, promoting enhanced knowledge transfer and structural inference within the learning paradigm. In contrast to conventional quantum machine learning methodologies that often rely on quantum hardware, this framework is fully realizable within classical computational architectures, thus bypassing the practical limitations of quantum hardware. The versatility of this model is illustrated through its application to critical domains such as medical diagnosis, resource-constrained natural language processing, and financial forecasting—areas where data scarcity impedes the efficacy of traditional models. Experimental evaluations reveal that quantum-inspired embeddings substantially outperform standard approaches, enhancing model resilience and generalization in high-dimensional, low-sample scenarios. This research marks a significant stride in integrating quantum theoretical principles with classical machine learning, broadening the scope of data representation and semi-supervised learning while circumventing the technological barriers of quantum computing infrastructure.
Researching the Impact of Corporate Social Responsibility on Economic Growth and Inequality – Methodological Aspects
Authors: Chipriyanov Mihail , Chipriyanova Galina , Krasteva-Hristova Radosveta , Atanasov Atanas , Luchkov Kiril
Published: October 2024

The study focuses of analysis the impact of corporate social responsibility (CSR) on economic growth and reducing inequality, highlighting the importance of CSR in achieving sustainable development and social justice. The main aim is to analyze how different CSR initiatives contribute to economic development, social prosperity and the reduction of inequality, reviewing the methods used to assess their impact. The research methodology includes a detailed literature review, bibliometric analysis and scientific mapping, surveys of various business organizations and a Gap Analysis regarding the identification of gaps between the current state of CSR activities and the expected outcomes. The research shows that companies perceive CSR as a key tool for improving corporate image, responding to stakeholder expectations and investing in social justice. Despite positive intentions, challenges include the lack of clearly defined methodologies for measuring impact on economic inequality, as well as difficulties in assessing the long-term effects of CSR initiatives. Key conclusions highlight the need for more structured approaches to assessing the social and economic effects of CSR, recommending that companies improve their transparency and accountability, and implement clear indicators of success to achieve sustainable economic and social outcomes.
Artificial Intelligence Based Target for Personalized Interventions of Atherosclerosis from Gut Microbiota Signature
Authors: Majumder Suravi , Sen Koushik , Karanjai Rabimba
Published: October 2024

Atherosclerosis remains a major driver for cardiovascular disease (CVD), despite advancements in traditional risk factor management therapies. Recent evidence emphasizes the crucial role of the gut microbiome in the progression of atherosclerosis and plaque rupture, highlighting a promising therapeutic avenue. This review focuses on the intertwined relationship between the gut microbiome, its metabolites, and atherosclerosis and CVD, also highlighting the potential therapeutic role of probiotics and prebiotics.

Given the diverse and unique gut microbiota signatures among individuals, a one-size-fits-all therapeutic approach is unlikely to be effective. Personalized treatment strategies are therefore necessary. Here we discussed how Artificial Intelligence (AI) can be leveraged to analyze individual gut microbiome profiles from microbiome sequencing, predict treatment response, and optimize therapeutic strategies based on individual patients which would significantly improve outcomes of the treatment for atherosclerosis/CVD patients.
Definitive Diagnosis of Pleural Mesothelioma by Pleural Effusion Cytology: The MesoCyto Study
Authors: Hashimoto Masaki , Minami Toshiyuki , Waseda Ryuichi , Takenaka Masaru , Uchimura Keigo , Yuki Michiko , Sato Ayuko , Kijima Takashi , Sato Toshihiko , Tanaka Fumihiro , Yatera Kazuhiro , Fujita Masaki , Hisaoka Masanori , Nabeshima Kazuki , Tsujimura Tohru , Hasegawa Seiki
Published: October 2024

Abstract: Objective: We evaluated the possibility of diagnosing pleural mesothelioma (PM) through pleural effusion cytology in a multicentric prospective clinical trial (MesoCyto study). Methods: We included patients with pleural effusion and suspected PM scheduled for thoracentesis and pleural biopsy. Both pleural effusion cytology including cell block and pleural biopsy were independently performed and compared to assess the diagnostic reliability of pleural effusion cytology. The primary endpoint aimed to demonstrate that the specificity of PM diagnosis by pleural effusion cytology reached 100%. Secondary endpoints included the frequency of adverse events during thoracentesis and pleural biopsy and assessment of diagnostic accuracy of pleural effusion cytology for each histological type. Results: Of the 50 enrolled patients, histological examination confirmed PM in 42 patients; 29 patients met the diagnostic criteria of PM in pleural effusion cytology and received a cytological diagnosis. Of the remaining 21 patients, 13 displayed atypical cells suggestive of PM based on pleural effusion cytology but did not meet the diagnostic criteria, and in 8, atypical cells were not identified and PM diagnostic criteria were not met. Thus, pleural effusion cytology specificity was 100%. The diagnostic concordance rate by pleural effusion cytology for each histological type was 72.2% for epithelioid, 75% for biphasic, and 0% for sarcomatoid. No adverse events were associated with thoracentesis, but the incidence of adverse events during pleural biopsy was 14%. Conclusions: PM can potentially be diagnosed through only pleural effusion cytology including the cell block method using immunohistochemical staining.
Macrophage-Like Blood Cells Are Involved in Inter-Tissue Communication to Activate JAK/STAT Signaling That Induces Antitumor Turandot Proteins in Drosophila Fat Body via the TNF-JNK Pathway
Authors: Kinoshita Juri , Kinoshita Yuriko , Nomura Tadashi , Inoue and Yoshihiro H.
Published: October 2024

Turandot (Tot) family proteins, which are induced via the JAK/STAT pathway after infection, also suppress lymph gland tumors in Drosophila mxcmbn1 mutant larvae. We investigated the potential role of hemocytes in Tot induction in tumor-bearing mutants by immunostaining and RNAi experiments. Normal hemocytes transplanted into mutant larvae were recruited to the tumor and fat body (FB), suggesting that these cells transmit tumor-related information. The transplanted hemocytes ectopically expressed Unpaired3 (Upd3), which is necessary to activate JAK/STAT. Eiger, a Drosophila Tumor necrosis factor (TNF) ortholog, was highly expressed in tumors. Depletion of the Eiger receptor in hemocytes reduced Tot levels and eventually enhanced tumor growth. The c-Jun N-terminal kinase (JNK) pathway, acting downstream of the receptor, was also activated in the hemocytes of mutants. Downregulation of the JNK pathway in hemocytes inhibited Tot induction, leading to enhanced tumor growth. These results suggest that the upd3 expression in hemocytes depends on the Eiger-JNK pathway. We propose that after Eiger activates the JNK pathway in hemocytes on the tumor, cells expressing Upd3 are recruited to the FB. Upd3 then activates JAK/STAT to induce the expression of antitumor proteins. This study highlights the intricate communication between tissues via blood cells during tumor suppression.
Polymorphisms of the Vitamin D Binding Protein (VDBP) and Free vitamin D in pediatric and young adult patients with cystic fibrosis
Authors: Quesada-Colloto Paula , Avello-Llano Noelia , García-Romero Ruth , Garriga-García María , Álvarez-Beltrán Marina , Reyes-Domínguez Ana Isabel , Fernández-Lorenzo Ana Estefanía , Gil-Peña Helena , Gómez-Alonso Carlos , García-Gil-Albert Carmen , Vicente-Santamaria Saioa , Peña-Quintana Luis , Díaz-Martin Juan José , Gutiérrez-Martínez José Ramon , Martin-Fernández Carmen , Mano-Hernández Agustín De la , Moreno-Álvarez Ana , González-Jiménez David
Published: October 2024

Objetives/Background: Vitamin D Binding Protein (VDBP) and free vitamin D are new markers that are being studied as a possible markers of vitamin D status. The main aim of our study was to analyse the VDBP genotype and quantify the levels of VDBP and free vitamin D in a sample of cystic fibrosis (CF) patients. Methods: Multicentre, cross-sectional and prospective study including patients with CF, exocrine pancreatic insufficiency who were clinically stable. We investigated vitamin D levels (total and free) and the different VDBP haplotypes. Free vitamin D levels were measured using an electro-chemiluminescence assay. Results: A sample of 48 patients was obtained (52% male; median age 13.8 years). The most common allele of VDBP was Gc1s (72%)>Gc2 (52%)>Gc1f (27%). Median calcidiol was 21.2 ng/ml (IR 15.3 - 26.9), 81% had levels in the insufficiency range: 23 patients (48%) below 20 ng/ml, and 16 (33%) between 20 and 30 ng/ml. The median free vitamin D level was 4.2 pg/ml (IR 3.9 – 5.6). A positive correlation was observed between calcidiol and free vitamin D levels (r=0.871; p<0.0001). After adjustment for season, vitamin D supplementation, sex and CFrelated diabetes, patients with Gc1f polymorphism had a lower risk of vitamin D deficiency, OR 0.22 (95% CI 0.05 – 0.99), p=0.027. A negative linear trend was observed between the polymorphisms grouped into 3 categories (Gc1/Gc1, Gc1/Gc2, and Gc2/Gc2, in that order) and vitamin D and free vitamin D levels (p=0.025 and p=0.033, respectively). Conclusion: In CF, as in the general population, the most common VDBP haplotype in Caucasian race is Gc1s. VDBP polymorphisms influence serum vitamin D and free vitamin D levels in CF patients. There is a good correlation between free vitamin D and calcidiol levels, suggesting that measuring the latter in CF does not seem to provide any additional benefit.
Examining Virtual Delivery of Strength at Home for Use of Intimate Partner Violence
Authors: Taft Casey T. , Benzer Justin K. , Kopitsky Megan , Creech Suzannah K.
Published: October 2024

This study examined the effectiveness of virtual delivery of the Strength at Home (SAH) intervention program for intimate partner violence in a sample of 605 military Veterans across 69 Veterans Affairs (VA) Medical Centers through a national implementation of the program. Outcome measures included physical IPV, psychological IPV, coercive control behaviors, posttraumatic stress disorder (PTSD) symptoms, and alcohol misuse. Significant pre-intervention to post-intervention reductions were found for all outcomes, with similar effect size estimates relative to a prior investigation of in-person delivered SAH through the same national VA implementation. Study findings suggest that virtual delivery of SAH may be as effective as in-person delivery which has important implications for program access and impact.
Aotearoa New Zealand Pet Owner Attitudes towards the Financial Cost of Pet Care
Authors: Awawdeh Leena , Forrest Rachel H
Published: October 2024

Background: Pet ownership is a common wellbeing enhancing practice globally, offering com-panionship and emotional support. However, it also entails financial responsibilities that can pose challenges and have negative wellbeing impacts for both human and animal.
Aims/Purpose: This study aimed to explore pet owners' the financial aspects of pet ownership in New Zealand, including the importance of pet insurance, the impact of veterinary costs, and the ethical considerations of owning a pet. Understanding these aspects of pet ownership is crucial for promoting responsible pet ownership and ensuring animal welfare.
Study Designs: Data was collected through a nationwide online survey conducted in 2019 as part of the Furry Whānau Wellbeing research project. The survey included questions about the financial aspects of pet ownership, and respondents were asked to indicate their level of agreement with various statements.
Findings: The study found that the cost of veterinary care is a significant concern for many pet owners, with 83.9% of respondents agreeing that expense is a factor in the level of healthcare their pets receive. While pet insurance can mitigate financial burdens, only a third of respondents considered it essential due to high costs and exclusions. The study also revealed disparities for rural and low-income households.
Conclusions: The financial aspects of pet ownership present a complex challenge, impacting both pet and owner wellbeing. This research highlights the need for comprehensive strategies to promote sustainable and equitable pet ownership, including improving access to affordable vet-erinary care, enhancing financial literacy among pet owners, and providing support systems for those facing economic hardship.
Flower Characteristics and Pollen Viability of Four Industrial Hemp (Cannabis sativa L.) Grain Varieties
Authors: Dingha Beatrice N. , Jackai Louis E.
Published: October 2024

Industrial hemp (Cannabis sativa L.) is primarily a dioecious plant, and monoecious varieties developed for high yield. Production practices vary by varieties prompting the need for the present study aimed to describe the floral characteristics and evaluate pollen quantity and viability of a monoecious (Henola) and three dioecious (CFX-2, Canda, and Joey) varieties. All varieties have five lanceolate anthers, basifixed to a threadlike filament. Anther length was significantly different but not anther width among varieties. The longest length (0.38 ± 0.046 cm) was recorded in Henola, and shortest (0.34 ± 0.043 cm) in CFX-2. Anther width ranged from 0.088 ± 0.0024 to 0.095 ± 0.0021cm. Pollen grains were triporate and spheroidal in shape and size differed significantly with the largest in Joey (27.83 ± 0.78 μm) and Henola (27.489 ± 0.99 μm), and smallest in Canda (22.04 ± 0.56 μm). The number of pollen grains differed significantly among varieties ranging from 29,183 in Henola to 104,548 in Joey. Even though Henola recorded the lowest pollen number it had the highest percentage (69.3%) of viable pollen and Canda recorded the lowest. There was a moderate, positive and significant relationship (r = 0.496) between anther length and the number of pollen grains in Joey. The relationship in Henola was moderate and non-significant (r = 0.356), weak and non-significant in Canda (r = 0.188), and in CFX-2 (r = 0.037). The findings from our study provide information for growers and researchers on hemp breeding and cultivation practices that may contribute to prevent cross pollination.
Characterization of Disease Patterns in Children with Intracranial Abscesses for Enhanced Clinical Decision-Making
Authors: Middelkamp Maximilian , Kania Marcus M. , Groth Friederike S. , Ricklefs Franz L. , Dührsen Lasse
Published: October 2024

Background: Intracranial suppurative infections in pediatric patients, while rare, pose a significant risk to patient mortality. Early recognition and fast initiation of diagnosis and treatment are crucial to prevent fatal outcomes. Between December 2022 and May 2023, a significant cluster of nine cases emerged, each necessitating neurosurgical intervention. This series highlights an important trend in clinical outcomes and raises questions about underlying factors contributing to this pattern. The need for surgical procedures in all instances suggests a commonality in severity, warranting further investigation into potential causes and preventative measures. This retrospective monocentric study aims to explore the clinical features associated with these cases to identify specific disease patterns that can expedite management in clinical practice.
Methods: Cramer’s V effect size was employed to evaluate combinations of clinical features, followed by Fisher’s exact test applied to a constructed contingency table. A p-value was assessed for significance analysis, with combinations achieving a Cramer’s V value of 0.7 or higher classified as exhibiting very strong correlations.
Results: The analysis revealed distinct patterns of clinical features among children diagnosed with intracranial abscesses. Significant associations were identified, including correlations between sinusitis and Streptococcus pyogenes, fever accompanied by affected temporal, frontal and frontobasal lobe regions.
Conclusions: Despite the generally limited statistical analysis of pediatric intracranial abscesses in the existing literature, this study provides meaningful significant associations between clinical features, delineating specific disease patterns. By addressing this gap, the findings contribute valuable insights and offer a framework that could enhance clinical decision-making and support timely disease management in pediatric cases.
DIKWP-TRIZ: A Revolution on Traditional TRIZ towards Invention for Artificial Consciousness
Authors: Wu Kunguang , Duan Yucong
Published: October 2024

We propose the DIKWP-TRIZ framework, an innovative extension of the traditional Theory of Inventive Problem Solving (TRIZ) designed to address the complexities of cognitive processes and artificial consciousness. By integrating the elements of Data, Information, Knowledge, Wisdom, and Purpose (DIKWP) into the TRIZ methodology, the proposed framework emphasizes a value-oriented approach to innovation, enhancing the ability to tackle problems characterized by incompleteness, inconsistency, and imprecision. Through a systematic mapping of TRIZ principles to DIKWP transformations, we identify potential overlaps and redundancies, providing a refined set of guidelines that optimize the application of TRIZ principles in complex scenarios. The study further demonstrates the framework’s capacity to support advanced decision-making and cognitive processes, paving the way for the development of AI systems capable of sophisticated, human-like reasoning. Future research will focus on comparing the implementation paths of DIKWP-TRIZ and traditional TRIZ, analyzing the complexities inherent in DIKWP-TRIZ-based innovation, and exploring its potential in constructing artificial consciousness systems.
The Potential of a Mobile Augmented Reality Game in Education for Sustainability: Report and Analysis of an Activity with the EduCITY App
Authors: Rodrigues Rita , Pombo Lúcia
Published: October 2024

The integration of augmented reality (AR) into education for sustainability curricula not only makes learn-ing more engaging, motivating, and effective, but also equips students with the knowledge and skills to address pressing environmental challenges. This paper presents a case study of a pedagogical approach based on the exploration of an AR game in the EduCITY app and aims to analyse the potential of the ‘EduCITY at the UA Campus’ mobile AR game in what concerns the promotion of education for sustaina-bility among secondary students. The game was explored in the largest annual event of the University of Aveiro – XPERiMENTA – which invited students and the wider community to participate in activities on the campuses. At the end of the activity, an individual and anonymous questionnaire to evaluate the game was applied. Students indicated that the game raises awareness of sustainability and contributes to the de-velopment of knowledge and skills in this area. They were motivated throughout the match and managed to get a good performance out of playing. This study adds to the literature on the use of AR games in edu-cation for sustainability, by revealing that it can be an effective tool for engaging and motivating students with sustainability-related learning.
Meta-Analysis on the Age-Specific Seroprevalence of Hepatitis A Virus in Turkey
Authors: Ciftci Ihsan Hakki , Koroglu Mehmet , Demiray Tayfur , Terzi Huseyin Agah , Kahraman Kilbas Elmas Pinar
Published: October 2024

Background: Hepatitis A virus (HAV) is a leading cause of acute viral hepatitis and is primarily transmitted via the faecal-oral route. The clinical presentation and progression of the disease vary based on the patient’s age. Turkey is classified as an intermediate endemic country, and HAV infection remains a significant public health issue worldwide. Methods: This study conducted a systematic meta-analysis to evaluate age-specific HAV seroprevalence rates in Turkey from 2000 to 2023. A comprehensive literature search identified 177 articles, of which 57 met the inclusion criteria. Studies were assessed for quality and categorized by age groups: 0-<5, 5-<15, 15-35, and >35 years and older. Statistical analysis was performed using Comprehensive Meta-Analysis software (CMA) and SPSS. Results: The meta-analysis found that HAV seroprevalence rates for the age group 0-<5 were 73.18%, for 5-<15 were 46.88%, for 15-35 were 55.77%, and for those aged >35 were 90.90%. The overall seroprevalence, calculated using a random effects model, was 64.5% (95% CI: 58.3-70). High heterogeneity (I² = 99.77) was observed across studies, and excluding low-quality studies resulted in changes to the prevalence estimate. Conclusions: This meta-analysis indicates that inclining trend in HAV IgG seroprevalence in Turkey, particularly among younger populations, likely due to the vaccination program initiated in 2012. Furthermore, the observed heterogeneity across regions highlights the importance of regional public health strategies. Future studies should focus on studies that provide more detailed data to evaluate the long-term effects of vaccination and explain regional differences in HAV seroprevalence.
On Schur Forms for Matrices with Simple Eigenvalues
Authors: Konstantinov Mihail Mihailov , Petkov Petko Hristov
Published: October 2024

In this paper we consider the standard Schur problem for a square matrix A, namely the similarity unitary transformation of A into upper Schur form containing the eigenvalues of A on its diagonal. Since the profound work of Issai Schur (1909), this is a fundamental issue in the theory and applications of matrices. Nevertheless, certain details concerning the Schur problem need further clarification especially in connection with the perturbation analysis of the Schur decomposition relative to perturbations in A. In particular, the concept of regular solution to the perturbed Schur form is introduced and illustrated by several examples. We also introduce the concepts of diagonally spectral matrices and of quasi-Schur condensed forms of a matrix A, and show that they may be much less sensitive to perturbations in A.
A Comparative Study of Chinese-Thai Speech Act of Request: A Case Study of Campus Scenarios
Authors: Sapermsup Noramon
Published: October 2024

A request is a common speech act in any language and is essential for successful communication. The study aims to compare the Chinese and Thai speech act of request in the campus scenario. Using the oral discourse completion test method, it examines the characteristics of request speech acts among 20 native Chinese speakers and 20 native Thai speakers. It focuses on analyzing the use of the initial action language in the request speech act, and the use of internal and external modifiers in the central action language. According to the research, it was found that although these two languages had some similarities in the implementation of the speech act of request, there were differences in many aspects and both had their own characteristics. This study argued that this difference was closely related to the Chinese and Thai socio-cultural characteristics.
Chinese Aesthetics of Situational Language Variety: A Study of 李薇 Character Studies in Drama 聊聊日常 (New Life Begins) 2022
Authors: Dewi Endah Putri , Nastiti Nawang Putri , Suryana Wahyu , Mintowati Maria , Adhimas Yogi Bagus
Published: October 2024

In social life, communication is needed to be able to interact with each other using various ways, one of which is by speaking using existing languages.  In language activities, there is a language phenomenon, namely the variety of languages according to the situation. Researchers decided to examine the drama 聊聊日常 (New Life Begins) (2022) because there are many data found on the variety of languages according to the situation used by the character 李薇 Lǐ Wēi. In this study, this author analyzes how the various forms of language used by 李薇 Lǐ Wēi characters according to the situation that is happening in the drama 聊聊日常 (New Life Begins) using the theory of Martin Joos (1967). Research data were obtained from various dialogues of 李薇 Lǐ Wēi characters with other characters contained in the drama 聊聊日常 (New Life Begins) with a descriptive qualitative approach. The results of the analysis showed that in episodes one to five of the drama 聊聊日常 (New Life Begins) Lǐ Wēi's character used all kinds of language according to the situation based on the level of formality according to Martin Joos (1967), namely frozen variety, official variety (formal), business variety (consultative), casual variety (casual), and familiar variety (intimate). However, it was found that Lǐ Wēi characters mostly use casual varieties.
Poemas
Authors: Omayra Gabriela
Published: October 2024

Fragmento: Después de encontrarnos entre las sábanas fuimos hacia la cocina, hablamos de esto, de aquello... de nada. Por instinto encendiste un cigarrillo con el frio. Caminaste dentro de la cobija y yo usé tu camisa.
Revisiting Securitization Theory within the context of North Korea: A theoretical analysis of the success of Trump’s policy
Authors: Arı Tayyar , Çetindişli Özge Gökçen
Published: October 2024

This empirical study, grounded in securitization theory, questions whether the security utterances of former U.S. President Donald Trump on North Korea between January 20, 2017, and June 12, 2018, constituted only a securitizing move or evolved into a successful securitization practice. The research employs a hybrid methodology, combining discourse and content analyses supported by quantitative data. The focus is on analyzing the discourse within a corpus of 44 securitization statements made by the president. These statements were discerned through a comprehensive review of all the president's public remarks throughout the designated period, using queries such as “North Korea,” “Democratic People's Republic of Korea (DPRK),” “Kim Jong Un,” etc. Employing discourse analysis, the study reveals the referent objects and securitization arguments in these statements. The data gleaned from these statements is subsequently analyzed utilizing content analysis methodology. This study also evaluates the securitization discourse by examining its compliance with the facilitating conditions of an effective securitization rhetoric, a capable securitizer, and an audience-acceptable threat selection. Subsequently, it discusses the efficacy of the securitization discourse in terms of the two principal parameters proposed by the Copenhagen School: audience acceptance of the threat narrative contained in the securitizing moves, and the adoption of extraordinary measures.
Steganography Image in Image using Modified method in Least Significant Bit (LSB) substitution
Authors: Al-Ani Suhad A. H.
Published: October 2024

فن الاختزال هو فَنُّ اختفاء وإرْسال رسالةِ خلال غطاءِ بعيد عنِ الشكَّ في محاولة لا َخفاء وجودَ الرسالةِ. في هذا البحث ِ تم تبني إخفاء صورة في صورة حيث تم تطبيق إخفاء صورة ذات تدرج رمادي في صورة ملونة (224 لون)،واستعملت تقنية تضمين الرسالة السرية بتقنية الحشر في (Least Significant Bit (LSB))
  في الصورةِالغطاءِ وتم اقتراح طريقتان في هذه التقنية Spin method and Look-up Table Method
 (ومقارنتهماُ بالطريقةِ التقليديةِ.ولصعوبة تمييز الاختلاف بين الصورة الغطاء والصورة الحاملة للرسالة، استخدمنا معيار معدل مربع الخطأ وجذر معدل مربع  الخطأ، كذلك معيار قمة نسبة الإشارة إلى الخطأ، وتم الحصول على نتائج ممتازة (فوق 60 ديسبيل).
Development of Spectrophotometric Method for Determination of Chlorpromazine-Hydrochloride in Pharmaceutical Preparations Via Use Ion-Exchange to Overcome the Interfering Ions
Authors: Kasim Bushra Basheer
Published: October 2024

تم التطرق في هذا البحث العلمي الى تقدير الكلوربرومازين (CPZ) اذ يعد افضل الادوية المستخدمة في الطب النفسي عن طريق الاكسدة المباشرة له بوجود نترات الحديديك المائية ولكميات قليلة جداً من الكاشف والمواد المتممة للتفاعل، حيث ان ما يستخدم من الكاشف الكيمياوي لايزيد عن 400 مكل (0.4 مل) وهو حجم ضئيل لامكانية اجراء تفاعل طيفي.
            اختيرت عوامل مؤكسدة مختلفة تضمنت فيري سيانيد البوتاسيوم(K3[Fe(CN)6])  والايودات(NaIO3) والبيرايودات(NaIO4) والبرومات(KBrO3) ونترات الحديديك(Fe(NO3)3.9H2­O) وفوق الكبريتات(K2S2O8) ونترات السيريوم(NH4)2[Ce(NO3)6] لانتخاب افضلها عند اجراء عملية الاكسدة للكاشف الطيفي (CPZ).وتمت دراسة وتقدير (CPZ) من خلال تكوين ناتج اكسدة ملون بتفاعلات اكسدة-اختزال. درست كافة المتغيرات الفيزياوية والكيمياوية وتم تحديد الظروف المثلى لعملية الاكسدة وفي اوساط حامضية مختلفة وجرت دراسة المتداخلات وازيل تاثيرها باستخدام اعمدة التبادل الايوني، وتم الحصول على نسبة خطية 99.86 للمدى (0.02-8 ملي مولاري) وبحد كشف 1×10-5 مولاري وبتكرارية اقل من 2%. طبقت الطريقة لتقدير الكلوربرومازين في المستحضرات الصيدلانية واعطت توافقاً مقبولاً عند التراكيز العالية والواطئة.
Study of Ratio fission width to total width for fission materials bombarded by monoenergitic neutrons
Authors: AL-Attabi Hadi Dawyich Zirzur , AL-Ammar Abbas Fadhil , Essa Hashim Ali
Published: October 2024

تهدف هذه الدراسة الى معرفة سلوك نسبة عرض الانشطارالى العرض الكلي للنواة المركبة لبعض المواد الانشطارية عند قصفها بالنيوترونات الاحادية الطاقة  كدالة لنصف القطر النووي ولمدى يتراوح بين واستنتاج المعادلات الرياضية التي يمكن خلالها دراسة هذا السلوك.كذلك استنتجت العلاقات التجريبية بالاستعانة بطريقة (Fitting Method) التي من خلالها يمكن التنبؤ او معرفة نسبة عرض الانشطار الى العرض الكلي عند طاقة النيوترونات الاحادية  وللنوى الانشطارية لذرة اليورانيوم  وذرة الثوريوم .
A General Framework to Describe Drilling Process States
Authors: Cayeux E. , Macpherson J. , Pirovolou D. , Laing M. , Florence F.
Published: October 2024

Automation and digitalization of drilling require shared knowledge about the state of the drilling process: Is the bit on-bottom drilling or is the string in-slips; is there an overpull or is there a formation fluid influx? The research question addressed here is whether it is possible to define clear, sharable, and usable definitions of what a drilling process state is, and an agreed method to calculate it. The method to define the drilling process state originates from the fact that a drilling operation can be described by a set of partial differential equations, respecting boundary conditions. Therefore, the set of possible discrete changes of boundary conditions defines the set of all possible drilling process states. The possible state values for each of these boundary conditions can be clearly defined by a set of logical expressions utilizing boundary values at the partial differential equations. Each boundary condition is called a microstate. If the set of microstates is linearly independent and complete, then the overall state of the drilling process is uniquely described by the state of each of the microstates. The boundary values are either measured or estimated using a digital twin of the drilling process. In either case, an uncertainty is associated with the boundary value. It is therefore possible to estimate the probability of being in one state or another for each of the microstates. This is an important property as often the actual state of the drilling process is uncertain. If several digital twins or measurements are available, it is also possible to use sensor fusion to update the uncertainty of the boundary value. A common drilling process interpretation engine and well-defined drilling process states may help with the coordination of multiple advisors participating in the control of the drilling process. An example is given showing how an event-based drill-a-stand procedure involving several external advisors is automatically executed using a common source for the interpretation of the drilling process state. A shared definition and method of calculation of the drilling process state is a fundamental element of an infrastructure to enable interoperability at the rigsite. This work is part of the Drilling and Wells Interoperability Standard (D-WIS) initiative. D-WIS is a cross-industry work group providing the industry with solutions facilitating interoperability of computer systems at the rigsite.