bluuebunny/crossref_metadata_2025 huggingface dataset:
VI Congreso Internacional ISUF-H. Forma urbana y resiliencia: los desafíos de salud integral y el cambio climático
Authors: Higueras García Ester , García-González María Cristina
Published: September 2022

ResumenEste número especial consta de una selección de las ponencias que serán presentadas en el Congreso ISUF-H 2022, que tendrá lugar en la Escuela Técnica Superior de Arquitectura de Madrid del 29 de septiembre al 1 de octubre de 2022. El ISUF-H es la red regional de la organización ISUF para los países de lengua española. Dedicado a la forma urbana y la resiliencia ante los desafíos actuales de salud integral y el cambio climático, presenta seis líneas de investigación: Forma urbana, vivienda y resiliencia, Forma urbana y ciudades saludables, Procesos urbanos, resiliencia y regeneración urbana, Espacios públicos para la inclusión, equidad y resiliencia, Espacios peri-urbanos, Infraestructura verde y azul para la resiliencia y adaptación al cambio climático y Urbanismo, informalidad autoconstrucción y riesgos.  AbstractThis special issue consists of a selection of the papers that will be presented at the ISUF-H 2022 Congress, which will take place at the Escuela Técnica Superior de Arquitectura de Madrid from September 29 to October 1, 2022. The ISUF-H, International Hispanic Seminar on Urban Form is the ISUF regional network for Spanish-speaking countries. Dedicated to the urban form and resilience to the current challenges of comprehensive health and climate change, it presents six lines of research: Urban Form, Housing and Resilience, Urban Form and Healthy Cities, Urban Processes, Resilience and urban regeneration, Public spaces for inclusion, equity and resilience, Peri-urban spaces, green and blue infrastructure for resilience and adaptation to climate change and Urbanism, self-construction informality and risks.
Paisaje comercial del centro histórico. Estudio comparado: Lisboa-Madrid
Authors: Díaz Sotelo Antonio
Published: September 2022

ResumenEl comercio organiza la ciudad desde la sedentarización del intercambio. El paisaje comercial favorece la legibilidad de la ciudad y un ambiente urbano saludable. Este estudio foma parte de una investigación sobre la Transformacion reciente del paisaje comercial del centro histórico de Madrid, que pretende establecer los factores de esa transformación, específicamente entre la del espacio público y la del zócalo. El objetivo de este estudio es contextualizar el análisis comparando con otro caso con marcos homogéneos: centros históricos con actividad económica compleja y significativa en ambas ciudades. Se desarrolla en tres capítulos de análisis (modelo de ciudad, espacio público y zócalo comercial) y conclusiones parciales.  El modelo pretende sintetizar el proyecto público para el paisaje comercial a partir del análisis de los instrumentos de intervención pública en la escena y la percepción. El espacio público se analiza como soporte de la percepción, descomponiendo la red viaria en escenarios concretos, tipificados y relacionados por la movilidad peatonal. El zócalo se analiza asumiendo el local como unidad de expresión escénica de las actividades, que protagoniza la transformación escénica del centro histórico. El modelo lisboeta es paisajístico, pero no es transformador de la escena urbana. La articulación administrativa de las directivas liberalizadoras ha devenido en un modelo dual, actuaciones sin control previo frente a otras con riguroso control patrimonial, que propicia actuaciones sin entidad arquitectónica. La diferente escala de las unidades de producción escénica —el tramo para el espacio público y el local para el zócalo— no está resuelta ni en ambos modelos y experiencias. En Lisboa se confirman tramas comerciales muy densas y ejes comerciales, autónomos de su propio entorno, con amplios entornos puramente residenciales; en Madrid la densidad comercial es mayor, se identifican ejes comerciales, pero apenas hay tramas residenciales ajenas a la actividad. Este estudio se centra en la situación anterior a la pandemia. La investigación general tiene por objeto la transformación, que se aborda comparando con la situación previa anterior a las directivas liberalizadoras y con la actual derivada de la pandemia.
Evaluation of zakat literature: A bibliometric analysis and systematic literature review
Authors: Apriliyah Risna Putri , Arifianto Bayu
Published: September 2022

Purpose – this study aims to determine previous research trends on zakat, assess the relationship of research collaboration, and identify future research directions.Methodology – It uses 87 articles published between 2009-2020 about zakat indexed in Scopus in Q1, Q2, and Q3. Using a qualitative and quantitative approach, the Bibliometric method and Systematic Literature Review (SLR). This study uses Vos Viewers software and Publish or Perish.Findings – It is known that three sub-themes dominate the research related to zakat: Implementation of zakat in alleviating poverty, zakat compliance, and distribution of zakat funds.Implications – This study implied that regulators can re-evaluate their regulations regarding zakat collection, management, and distribution. This is because they expect researchers, practitioners, and regulators to establish and implement policies for the future.Originality – It identifies three sub-themes that dominate research related to zakat, they are Implementation of zakat in alleviating poverty, compliance with zakat, and distribution of zakat funds.
Ibn Khaldun's insight: Intellectual capital for entrepreneurship using wordclouds and netnography
Authors: Wahyudi Dicky
Published: September 2022

Purpose – This paper aims to identify Ibn Khaldun's philosophy on the contribution of intellectual capital to increasing business performance for MSMEs.Methodology – Using literature studies and observations of online data, this paper focuses on identifying the typology of content used by internet users on Youtube channels to capture the involvement of entrepreneurs during the Covid-19 pandemic era. This study is conducted using the Netnographic method, whereas the Wordcloud technique was used to generate information for entrepreneurship from the youtube channel. The relevant channel is entitled “UMKM: Paling Tangguh Meskipun Kalah “Seksi," which means "The greatest MSMEs even though they are less "attractive".Findings –The theory described by Ibn Khaldun is identical to intellectual capital, and the views of other researchers have been classified in this paper: (1)human capital, (2)organizational capital, (3)relational capital, (4)spiritual capital and (5)technological capital.Implications – This paper provides an alternative thought for the development of MSMEs to utilize intellectual capital to face the Covid-19 pandemic era and financial capital such as debt.Originality – This research attempted to show the scope of Ibn Khaldun's insight focuses on the process of economic development, but no one has yet discussed how Ibn Khaldun's view of economic philosophy relates to increasing business performance for MSMEs.
Metal Coordination Effects on the Photophysics of Dipyrrinato Photosensitizers
Authors: Teeuwen Paula C. P. , Melissari Zoi , Senge Mathias O. , Williams René M.
Published: September 2022

Within this work we review the metal coordination effect on the photophysics of metal dipyrrinato complexes. Dipyrrinato complexes are promising candidates in the search for alternative transition metal photosensitizers for application in photodynamic therapy (PDT). These complexes can be activated by irradiation with light of a specific wavelength, after which cytotoxic reactive oxygen species (ROS) are generated. The metal coordination allows for the use of the heavy atom effect, which can enhance the triplet generation necessary for generation of ROS. Additionally, the flexibility of these complexes for metal ions, substitutions and ligands allows the possibility to tune their photophysical properties. A general overview of the mechanism of photodynamic therapy and the properties of the triplet photosensitizers is given, followed by further details of dipyrrinato complexes described in the literature that show relevance as photosensitizers for PDT. In particular, the photophysical properties of Re(I), Ru(II), Ir(III), Ni(II), Cu(II), Pd(II), Pt(II), Zn(II), Ga(III), In(III), Al(III), Sn(II), and P dipyrrinato complexes are discussed. The potential for future development in the field of (dipyrrinato)metal complexes is addressed and several new research topics are suggested throughout this work. We propose that significant advances could be made for heteroleptic bis(dipyrrinato)zinc(II) and homoleptic bis(dipyrrinato)palladium(II) complexes and their application as photosensitizers for PDT.
Physical Impact of a Typical Training Session With Different Volumes on the Day Preceding a Match in Academy Soccer Players
Authors: Douchet Tom , Paizis Christos , Babault Nicolas
Published: September 2022

French academies almost all implement reactivity drills and small-sided games (SSG) the day preceding a match (MD-1). The present study aimed to determine the physical impact of different training durations on MD-1 on the subsequent matchday performance (MD). Eleven elite U19 academy soccer players con-ducted three typical training sessions lasting 45min (TS45), 60min (TS60), and 75min (TS75) on MD-1. Dur-ing TS60, warm-up, reactivity and SSG were 10, 15, and 24min, respectively, plus coaches' feedback or wa-ter breaks. Durations decreased and increased by 25% for TS45 and TS75, respectively. Tests were con-ducted on MD-4 (CONTROL) and MD before the match (TEST). Tests consisted of a counter movement jump (CMJ), 20m sprint, Illinois agility test (IAT), and Hooper questionnaire. CONTROL values were simi-lar over the three experimental conditions. TEST on MD revealed greater CMJ for TS45 (42.7 ± 5.1cm) compared to TS60 (40.5 ± 5.5cm, p=0.032) and TS75 (40.9 ± 5.7cm, p=0.037). 20m time was lower for TS45 (3.07 ± 0.10s, p<0.001) and TS60 (3.13 ± 0.10s, p=0.017) compared to TS75 (3.20 ± 0.10s). IAT time was lower on TS45 (14.82 ± 0.49s) compared to TS60 (15.43 ± 0.29s, p<0.001) and TS75 (15.24 ± 0.33s, p=0.006). Further-more, the Hooper index was lower at TEST for TS45 (7.64 ± 1.50) compared to TS60 (11.00 ± 3.49, p=0.014) and TS75 (9.73 ± 2.41, p=0.045) indicating a better readiness level. We concluded that as training session duration increases, performance decreases on MD. A 45min training session including reactivity and SSG exercises is therefore recommended on MD-1.
Occurrence of Silver, Bighead, and Black Carp in waters managed by the US Army Corps of Engineers
Authors: Oliver Amanda , Slack William , Katzenmeyer Alan
Published: September 2022

This technical report (TR) documents the distribution of Invasive Carp - Silver Carp (Hypophthalmichthys molitrix), Bighead Carp (Hypophthalmichthys nobilis), and Black Carp (Mylopharyngodon piceus) in US Army Corps of Engineers (USACE) managed waters. Invasive carp were introduced into the US nearly half a century ago. As they spread across the US, they compete with and consume native species and Silver Carp jumping behavior reduces recreational use. The USACE is responsible for management of waterbodies at more than 440 projects. Information on these projects including the presence of Invasive Carp is reported in the USACE Operations and Maintenance Business Information Link (OMBIL) database. To supplement the Invasive Carp information from OMBIL, 47 online ichthyology collection and observation databases were searched; 18 had information on Invasive Carp locations. Combining the collection, observation and OMBIL reporting information, 82 USACE projects in 19 districts in 6 of 8 divisions have Silver/Bighead Carp and 19 projects in 9 districts and 3 divisions have Black Carp. Understanding the distribution of Invasive Carp is important to enable managers to be proactive: planning control efforts, posting informational signs, instituting live bait restrictions, and thus reducing the chances of species introduction or limiting species impact.
Deep Learning Model for CO2 Leakage Detection Using Pressure Measurements
Authors: Zhang Zhen , He Xupeng , AlSinan Marwah , Li Yiteng , Kwak Hyung , Hoteit Hussein
Published: September 2022

Geologic CO2 sequestration (GCS) has been considered a viable engineering measure to decrease global CO2 emissions. The real-time monitoring to detect possible CO2 leakage is an important part of big-scale GCS deployment. In this work, we introduce a deep-learning-based algorithm using a hybrid neural network for detecting CO2 leakage based on bottom-hole pressure measurements. The proposed workflow includes the generation of train-validation samples, the coupling process of training-validating, and the model evaluation. This work solves the diffusivity equation for pressure within a simulation framework, used to generate datasets under no-leakage conditions. A Bayesian optimization process is performed to optimize the model hyperparameters. We test the performance of the hybrid neural network, referred to as Convolutional Neural Network (CNN) and Bi-directional Long Short-Term Memory (CNN-BiLSTM) on the bottom-hole pressure data collected from CO2 leakage simulations. Results show that the CNN-BiLSTM model can successfully detect CO2 leakage events by comparing the difference between the predicted (no leakage) and tested bottom-hole pressures. We further compare its superiority with Convolutional Neural Network (CNN), Long Short-term Memory (LSTM), Bidirectional Long Short-term Memory (BiLSTM), and CNN-LSTM. Our proposed model achieves the highest accuracy with the same datasets. The CNN-BiLSTM outperforms other models owing to 1) its capacity to process image-based input, which could accurately capture input formation, especially in cases with highly heterogeneous permeability; 2) its bidirectional ability to capture time-series dependency. Other models, like LSTM and BiLSTM, take value-based input, which is insufficient to describe the input information in highly heterogeneous cases. In contrast, the CNN model suffers from capturing the temporal dependency features. This approach provides an efficient and practical CO2 leakage detection method and can be implemented in large-scale GCS for real-time monitoring applications.
Downhole Three-Phase Flow Measurement Using Sound Speed Measured by Local or Distributed Acoustic Sensing
Authors: Ünalmis Ö. Haldun
Published: September 2022

In-well multiphase flow measurement continues to be a challenging task in the oil and gas industry. One promising technology to achieve this goal is the distributed acoustic sensing (DAS) system deployed downhole along a fiber. A DAS system is usually capable of measuring speed of sound (SoS) and, depending on the type of application and how the system is installed/configured, it may also measure flow velocity. In its current state, the DAS technology is still not fully explored in multiphase flow measurement for reasons including but not limited to the lack of flow algorithms and methodologies that can use measurements in a combinative and coherent approach. The current work introduces a game-changing methodology in applying the DAS and other sound measuring optical or electronic technologies to measure 3-phase flow.

The 3-phase flow measurement methodology is based on the measurements of SoS at different locations along the well where the pressure is greater than the bubble-point pressure (P>Pb) at the first location and P<Pb at the second location. A bulk velocity measurement is also necessary at one of the locations, preferably at the second location. The minimum required measurements to resolve 3-phase flow rates are SoS at both locations (SoS1 and SoS2), pressure/temperature (P/T) values at both locations (P1, P2, T1, T2), and the bulk velocity measurement at the second location (V2). Using these measurements, phase flow rate calculations in a 3-phase flow are possible. A Lego-like approach may be used with various sensor technologies to obtain these required measurements which are then used in a consecutive manner in 2-phase and 3-phase solution domains obtained using Wood and Korteweg-Lamb equations.

The methodology is fully explained and the analytical solutions for 3-phase flow measurement is explicitly provided in a step-by-step approach. This approach provides significant advantages over the traditional methods. For example, SoS measurements along the well at multiple locations by using the same sensor technology or by combining different sensor technologies make this methodology highly flexible and applicable to custom-fit solutions. The method is independent of the sensor type as long as the sensors measure SoS, though the ideal systems that can adopt it easily and efficiently are DAS and optical flowmeters (OFMs). Additionally, a developing case history involving downhole OFMs installed in a North Sea field-wide application is discussed. The methodology may be implemented for a special case in which SoS is measured at the same location but at different times.

This new methodology in measuring downhole 3-phase flow furthers the understanding of downhole multiphase flow measurement. It can be implemented in existing wells with optical infrastructure by adding an appropriate topside optoelectronics system when needed at later phases of production.
Principles for Managing Reserves and Resources in Albania via Petroleum Resources Management System
Authors: Buranaj Hoxha Bez
Published: September 2022

Albania has an active but challenging drilling activity that demands the most innovative technology. Although new recent drilling activity, has discovered light crude oil, the predominant crude oil quality involves medium-heavy oil reservoirs mainly contained in the largest onshore European oilfield, Patos-Marinza. Even though it has high potential, Albania’s main reservoirs are practically under-developed. In the past decade, the Albanian institutions have increasingly encouraged and supported expanding drilling activity in an effort to stimulate investments in reservoir development/production and management. However, petroleum economics and appropriate management systems need to be further improved to assist in reserve ‘asset’ management. This requires, specifically, employing a collective reserves management system, Petroleum Resources Management System (PRMS), which utilizes a framework and guidelines for resource competencies to evoke necessary asset management in reserves and resources.

In this paper, a basic outlook is undertaken to evaluate Albania’s resources and oil/gas reserves in a preliminary assessment to classify the reserves under the PRMS guidelines. The main idea will show how a small country with great potential, can exploit its vast resources, and ultimately capitalize on a structured systematic approach by essentially arranging a management system that is customizable and suitable as per its situation to ultimately leverage financial gains.

Additionally, an analogous resources management system that is used for characterizing and identifying possible storage areas for CO2 (carbon sequestration) will also be briefly introduced that is based on the CO2 Storage Resource Management System (CO2-SRMS). Which, herein, will spotlight possible suitable areas of carbon storage in Albania.

These types of management systems are crucial in decision making, offering considerably ‘better judgments’ in managing and developing resources by ranking the most suitable investment opportunities.
Automated Unmanned Systems Perform Safe Emissions Quantification & Reduction in Permian Operations
Authors: Churchill Jason , Wise Brenda , Cooper Iain , Smith Brendan
Published: September 2022

Traditional methods for monitoring emissions from production operations have typically employed optical gas imaging (OGI) cameras or Method 21 systems, based on an intermittent basis to determine and document methane gas leaks, which are then subsequently identified for repair (CFR, 2022). These OGI emissions monitoring surveys can have a subjective bias, are highly conditional on the skill of the camera operator, and are an inexact method of measuring quantity of the leak rate. With a renewed industry emphasis on methane emissions measurement and reduction, this paper describes a case study using a high-sensitivity sensor technology specifically targeting methane emissions, the unique capabilities engendered by its deployment on unmanned aerial systems (UAS), specifically leveraging automation in field-operation and data analysis, and its successful utilization in enabling emissions limitations over several production sites in the Permian.

The use of automation enabled categorization of the leak type and intensity, and triage according to leak rate, facilitating prompt remedial action, directly limiting emissions. By automating the comprehensive flight paths, specific to equipment groups, e.g., compressors, tanks, flares etc., targeted repeat surveys confirmed that specific leaks were fixed, emphasizing a general downward trend in overall site- and asset-level emissions. Additionally, the use of high resolution UAS-generated orthomosaic maps enabled the direct placement of emissions data into the context of the actual operations at the time of the survey. also facilitating the generation of automated actionable reports, enabling repair teams to be directed, resulting in effective and necessary fixes. Furthermore, the campaign validated that following the set-up of the initial survey, subsequent regular, repeat surveys could be commissioned at the "push of a button", yielding reliable, actionable emissions data, with a direct impact on both environmental and financial impact.
Innovative Approach to Maximizing Completion Drill Bit Longevity
Authors: Lyles Dustin , Devers Cameron , Dyer Warren , Lyles Shawn
Published: September 2022

For almost a decade, the predominant completion drill-out bits utilized to drill composite frac plugs were roller-cone (RC) bits incorporating "hybrid" cutting structures. RC hybrid cutting structures consist of various layouts incorporating a combination of milled teeth (MT) and tungsten carbide insert (TCI) cutting elements that exhibit known trade-offs regarding longevity and performance. The objective of this paper is to illustrate how practicing engineers can, and should, question status quo to overcome traditional design/performance limiters. Extensive analysis of hybrid RC dull bits and performance data was conducted with the goal to advance RC completion drill bit longevity and performance while reducing non-productive time (NPT). Through quantifying and classifying cutting structure damage across 30 RC hybrid drill bits, data collected clearly illustrated which portions of the bit profile and cutting elements were sustaining the most damage. The data indicated commonly accepted hybrid RC designs display an inherent weakness that would require questioning common beliefs about completion RC bit design and manufacturing methodologies. A new bit design was developed and extensively field tested. The results of the dull bit evaluation indicated the MT are inherently less robust and result in more performance limiting cutting structure damage. The MT have been utilized as a standard due to industry acceptance, manufacturing limitations associated with implementing the more robust TCI's in all portions of the bit profile and perceived benefits with MT geometry. Implementing full TCI coverage to mitigate cutting structure damage required rethinking longstanding manufacturing methods and cutting element selection that have been accepted as industry standards. Changes in manufacturing methodology required increasing surface hardness of the cone face around TCI's to avoid loss due to interaction with slip debris and/or weakened TCI retention due to erosion. This change required a substantial and challenging shift in heat-treating methods and manufacturing workflow. Further changes were made to the TCI geometries in the new design to ensure the aggressiveness needed to fail soft composite plug materials into small debris sizes was equivalent or better than the MT cutting elements. The manufacturing, material and geometric changes resulted in a solution that contradicted previous trade-off understandings regarding completion drill bits by simultaneously improving durability and aggressiveness. The work exemplifies the importance for practicing engineers continuously to question status quo in pursuit of continuous improvement even when faced with longstanding beliefs and/or methodologies. Furthermore, the findings from the project give insight into completion drill-out trends and opportunities to reduce NPT and improve efficiency.
Multilateral Technology Enables Record Reservoir Contact in North Sea Subsea Well
Authors: Kelsey Matthew , Fanchin Thomas , Van Der Veen Steffen , Dahl Espen , Harila Skjold Kristina
Published: September 2022

In the 1990's many oil plays in the North Sea were originally deemed uneconomical due to the limited technology available to address the associated challenges. Horizontal and eventually multilateral applications were introduced to address this challenge. For over two decades multilateral technology has extended the production life of these fields by continuing to evolve to meet the demands of increasingly complex subsea applications.

Over this history, multilateral applications have evolved from dual-laterals with standalone screens and commingled flow to tri-lateral and quad-lateral intelligent completions as common multilateral completion strategies in the North Sea. A significant number of wells originally completed as a dual-lateral have since been recompleted twice or even three times to produce reserves previously left behind.

As investment and availability of new fields decline, operators face challenges to extend the production life of mature fields while also working to reduce overall development cost, cycle times, and carbon footprint. Further challenges include delivery of wells and facility systems using less in-field construction hours at a lower baseline cost.

This paper will focus on the evolution of a mature well in a region that has been installing multilateral wells for over two decades. Originally drilled as the world's first tri-lateral well and several years later re- drilled again as a quad-lateral to add further reservoir contact. As production decline and strategic targets esteemed to be more profitable are within reach from the same template, further re-drills as a dual-lateral and then a further quad-lateral has been utilized to add significant reservoir contact for further economic production.

It highlights the technology used to keep this well on production for over two decades and the benefits of expanding the use of this technology as fields become slot restricted. It also highlights the benefits this technology delivers in significantly increasing reservoir exposure and the time savings brought by drilling new lateral legs in existing subsea wells. The case study will include discussion of workover operations, completions, isolation methods, and lateral creation systems.

Through four separate multilateral installations in one subsea slot, the production life has been extended beyond 20 years. The paper also provides insight as to methodology for continually improving reliability of multilateral installations to maximize efficiencies.
Multi-criteria Fitness Function based Genetic Optimization of AODV Routing Protocol in MANETs
Authors: Mehta Ridhima
Published: September 2022

The artificial intelligence search techniques are widely used to achieve performance enhancement in wireless communication systems. One such methodology of evolutionary genetic programming inspired by nature is essentially appropriate for optimized operation in the context of wireless multi-hop ad-hoc networks with several challenges to provide the necessary network services. In this paper, we develop a reliable and efficient data routing scheme employing the conventional AODV protocol based on the dynamic genetic algorithm. It is aimed at effectively allocating the scarce radio resources and improving the QoS among the wireless devices in MANETs by joint optimization of network attributes including the data transfer rate, link transmission power and round trip delay. The proposed genetic algorithm based routing scheme utilizes two different fitness functions, together with binary data coding and decoding, single-point crossover and random mutation operators to assess the fitness measure of the specific solution space and network operational characteristics. This computational learning method is trained through the sample dataset obtained via the simulation experiments of the basic AODV routing scheme. With the emerging size of the sample network data records, the deployed polynomial and logarithmic fitness functions are compared in terms of power consumption and delay metrics to design a robust and adaptive data communication scheme. Finally, our smart network data learning and genetic optimization model is compared with the previous related models to demonstrate its improved performance in terms of lower power consumption, higher throughput, and greater values of average fitness measure.
Evaluation of the safety and efficacy of tripterygium wilfordii glycosides for patients with primary sjgren's syndrome : protocol for a prospective, double-blinded, randomized, placebo-controlled clinical trial
Authors: Ju Yanjuan , Li Rongping , Dong Xiaofan , Zhou shenghui , Hu Jin , Guo Dibin
Published: September 2022

Background: As a common autoimmune disease, primary sjogren's syndrome(pss) has limited therapeutic agents. For some patients with Sjogren's syndrome complicated with serious complications, taking glucocorticoid combined with cyclophosphamide treatment can obtain good results. However, the side effects of long-term use of glucocorticoid and cyclophosphamide limit its application in patients without extraglandular manifestations. Some animal experiments have shown that tripterygium wilfordii polyglycosides tablets have immunomodulatory effects. The immunomodulatory function of Tripterygium polyglucoside was found in some animal experiments. Some Single center, small sample, non-randomized control studys have proved that tripterygium wilfordii glycosides can allevitate dry eye,dry mouth and serological immunological abnormalities in the patients with PSS .Therefore, we designed this research to study the effect of tripterygium wilfordii glycosides for patients with primary sjgren's syndrome by measuring the reduction of serum globulin,IgA、IgG、IgM、TNF – α，as well as the extent of dry eye and mouth.
Methods : This study is a 12-week, single-center, prospective, double-blinded, randomized, placebo-controlled clinical trial developed from July 2022 to December 2023. Forty individuals with Primary Sjögren’s syndrome without extraglandular manifestations will be recruited and randomly assigned to receive tripterygium wilfordii glycosides or a placebo，and each group will have 20 subjects. During the 12-week observation period, there will be 4 visits. The decline in serum immunoglobulin IgG, IgM, IgA and tumor necrosis factor –α is the main outcome measure, and change of dry mouth, dry eye : Natural saliva flow rate、Schirmer's test、Tear break-up time and Adverse reactions: damage of blood system, liver and kidney function are the secondary outcome measures.
Discussion: This study will probe the effect of tripterygium wilfordii glycosides in the treatment of pSS and explore possible therapeutic mechanisms. By performing this trial, we hope to provide evidence and data to support further large clinical studies.
Trial registration: Chinese Clinical Trial Registry ChiCTR2200062262. Registered on 31 July 2022.http://www.chictr.org.cn/edit.aspx?pid=175924&htm=4
The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice
Authors: Roussel Julien , Larcher Romaric , Sicard Pierre , Bideaux Patrice , Richard Sylvain , MARMIGERE Frederic , Thireau Jérôme
Published: September 2022

Recent understanding of Autism Spectrum Disorder (ASD) showed that peripheral primary mechanosensitive neurons involved in touch sensation and central neurons affected in ASD share transcriptional regulators. Mutant mice for ASD-associated transcription factors exhibit impaired primary tactile perception, and restoring those genes specifically in primary sensory neurons rescue some of the anxiety-like behavior and social interaction defects. Interestingly, peripheral mechanosensitive sensory neurons also project to internal organs including the cardio-vascular system, and an imbalance of the cardio-vascular sympatho-vagal regulation is evidenced in ASD and intellectual disability. ASD patients have decreased vagal tone, suggesting dysfunction of sensory neurons involved in cardio-vascular sensing. In light of our previous finding that the ASD-associated Meis2 gene is necessary for normal touch neurons development and function, we investigated here if its inactivation in mouse peripheral sensory neurons also affects cardio-vascular sympatho-vagal regulation and baroreflex. Combining echocardiography, pharmacological challenge, blood pressure monitoring and heart rate variability analysis, we found that Meis2 mutant mice exhibited a blunted vagal response independently of any apparent cardiac malformation. These results suggest that defects in primary sensory neurons with mechanosensitive identity could participate in the imbalanced cardio-vascular sympatho-vagal tone found in ASD patients, reinforcing current hypotheses on the role of primary sensory neurons in the etiology of ASD.
Comparative safety of infliximab and adalimumab on pregnancy outcomes of Women with Inflammatory Bowel Diseases: A Systematic Review & Meta-Analysis
Authors: Wang Han , Hu Yue , Chen Fang , Shen Mengdie
Published: September 2022

Background
Inflammatory bowel disease (IBD) is a condition that affects most of the digestive tract. There is no report of fertility reduction in medically managed IBD women compared with the general population. On the other hand, active IBD can lead to significantly decreased fertility. Over the previous 2 decades, anti-tumor necrosis factor (anti-TNF) has been an effective treatment for managing patients with Crohn's disease, increasing the use of infliximab and adalimumab in clinical practice. However, it is unclear which biologics are more effective in pregnant women with IBD.
Aim
We conducted a systematic review and meta-analysis for the risk of adverse pregnancy outcomes following treatment with infliximab and adalimumab in women with IBD.
Methods
Bibliographic databases were retrieved from their inception to July 2022. The results were adverse pregnancy outcomes, including congenital malformations and spontaneous abortion.
Results
A total of 8 studies included 527 pregnant women with IBD. Of these, 343 received infliximab, and 184 received adalimumab therapy. Compared to adalimumab, adverse pregnancy outcomes were not increased in infliximab therapy.
Conclusion
Infliximab and adalimumab therapy did not show the difference of risk in adverse pregnancy outcomes such as congenital malformations and spontaneous abortion.
Systematic Review Registration:
http://www.crd.york.ac.uk/PROSPERO , identifier: CRD 42021277869.
A comparative study on the effects of hemp seed oil versus four different UFA-rich seed oils in the diets of laying hens on egg production, egg quality and yolk fatty acids
Authors: Kanbur Gülşah , Göçmen Rabia , Cufadar Yusuf
Published: September 2022

This study compared the effects of hemp seed oil versus four different UFA-rich seed oils in the diet of laying hens on egg production, quality, and fatty acid profile of the yolk. Soybean, sunflower, corn, canola, and hemp seed oils were included in the hens' diets in equal proportions. A total of one hundred and twenty 42-week old White Leghorn hens were placed in five diet groups with 8 replicates. The trial lasted 84 days and data were collected on egg production, quality, and fatty acid profile of the yolk. The data showed that none of the incorporated seed oils affected egg production or quality. However, hemp seed oil altered yolk colour values similarly to canola oil by increasing the L* value of the yolk while decreasing the a* value (P < 0.05). Hemp oil increased the PUFA content in the yolk, similar to soybean, corn, and sunflower oil, but unlike the latter, it also enriched the n-3 fatty acids in the yolk (P < 0.05). In conclusion, hemp seed oil can be safely used in the diet of chickens without having negative effects on egg production and quality like other seed oils. Furthermore, hemp seed oil can improve the desirable fatty acid content in the yolk and has the potential to produce n-3 design eggs.
The composition of Gut microflora of stingless honey bee (Apidae: Tetragonula) from Dharangaon taluka of Jalgaon district
Authors: Nikam Varun B. , Salunkhe Hemant. P. , Chopda Manoj. Z.
Published: September 2022

Stingless bees are the main pollinators in tropical regions because they entirely rely on flowers for nectars and pollen to feed their larvae. They help in pollinating many forests and are valued pollinators in biodiversity. Tetragonula /Trigona is known as the largest genera of stingless bees comprising 32 species worldwide and (meliponini) is by far the largest group of eusocial bees on earth with more than 500 described species and 43 species occurring in the Asian region. In a sterile environment, we surface-sterilized the bees in 75% alcohol for 20 s and then washed them with sterile water. Finally, the entire gut was removed from the abdomen of each bee. The sample was homogenized with 1 ml of Insect saline solution. 16S RNA analysis was performed by the outsourcing service from Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram.The results showed that the gut of stingless bees contained the bacteria of the Priestia genus
LS solving of nonlinear equations by the T-Secant method with super-quadratic convergence
Authors: Berzi Peter
Published: September 2022

A new secant-method based numerical procedure (T-secant method) with super-quadratic convergence (convergence rate 2.618) has been developed for least-squares solving of simultaneous multi-variable nonlinear equations. The basic idea of the procedure is that the original secant equations are modified by a non-uniform scaling transformation “T”, an additional new estimate is determined in each iteration and a completely new set of trial solutions is constructed for the next iteration. The suggested method seems to eliminate the unstable behavior of the traditional method and the efficiency is an order higher than Broyden’s methods in case of the numerical example. The vector-based interpretation and its geometrical representation helps to explain the basic operations. The performance of the new method is demonstrated by the results of numerical tests with a Rosenbrock-type test-function with up to 1000 unknown variables.
Dynamic Prediction of Preharvest Strawberry Quality Traits as a Function of Environmental Factors
Authors: Hopf Alwin , Boote Kenneth J. , Plotto Anne , Asseng Senthold , Zhao Xin , Shelia Vakhtang , Hoogenboom Gerrit
Published: September 2022

Fruit quality is of increasing importance for consumers but is a complex trait for growers, as it is affected by environment, genotype, and crop management interactions. Decision support tools, such as computer models that simulate crop growth and development can help optimize production but require further improvement to simulate quality aspects. The goal of this study was to apply the newly developed CROPGRO-Strawberry model in the Decision Support System for Agrotechnology Transfer (DSSAT) model framework and develop a module for the dynamic prediction of quality traits for strawberry. Experimental data from Florida with quality measurements from multiple harvests were correlated with indices based on preharvest weather conditions (temperature, radiation, rainfall) and simulated model parameters (evapotranspiration) during fruit development. Two quality relationships based on linear equations were identified and integrated into the model to simulate strawberry fruit soluble solids content (r2 = 0.89, d = 0.97) and titratable acidity (r2 = 0.55, d = 0.85) based on preharvest temperature. A strategic analysis with historical weather data for a subtropical growing region over a 10-year period showed the importance of seasonal climate variability for simulated strawberry yield and fruit quality across different harvest months. The improved CROPGRO-Strawberry model is the first process-based crop model to predict selected quality traits across multiple harvests throughout the season and can be extended to other crop models for which quality traits are important.
Farm-level Losses and Grower Willingness to Try Management Strategies for Swede Midge in Vegetable Crops
Authors: Hodgdon Elisabeth A. , Campbell Andrea E.M. , Conner David S. , Hoepting Christine A. , Galimberti Andrew K. , Chen Yolanda H.
Published: September 2022

Since its introduction to North America in the 1990s, the invasive swede midge (Contarinia nasturtii) has become an important pest of cruciferous (Brassicaceae) vegetables in the northeast and Great Lakes regions of the United States and the Canadian provinces of Québec and Ontario. Swede midge reduces yield in cruciferous vegetables through larval feeding that distorts growth. Overlapping generations, cryptic larval feeding, and lack of effective biopesticides pose challenges for managing swede midge effectively using current tools. In 2018, we distributed an online survey for commercial vegetable growers in the United States and Canada to measure farm-level economic impacts of swede midge and grower perspectives on new management strategies for this pest. Growers reported losing $3808 US ($4890 Canadian) on average per acre per year due to swede midge–related vegetable crop losses. Both organic and conventional growers expressed an interest in paying more for nonchemical swede midge management vs. insecticides and were interested in trying new management strategies, particularly biological control.
The moderating role of IFRS in the relationship between risk management and financial disclosure in Jordanian banks
Authors: Ahmad Alawaqleh Qasim , Hamdan Mohammad , Al-Jayousi Ahmed , Airout Rana
Published: September 2022

This study investigated the impact of IFRS on the relationship between risk management and financial disclosure in Jordanian banks in light of the Covid-19 pandemic. The study data were collected from Jordanian banks’ financial reports with the help of panel data to measure IFRS and risk management. The study depended on daily data, at a rate of (256) trading days from March 3, 2020 until April 29, 2021. Also, the study used questionnaires to measure financial disclosure in addition to interviews with eight Jordanian bank managers. Multiple regression was used to test hypotheses. The study found a positive statistically significant relationship between risk management and financial disclosure. The relationship was portrayed by a coefficient of 0.315. The result also showed the moderating role of IFRS in such a relationship, the effect reached 0.696. The conclusions have implications for both theory and practice. In fact, the findings elucidated the connection between risk management, IFRS, and financial disclosure. Finally, Jordanian banks should focus on IFRS and risk management, enhanced management, and employee skills as recommendations in this study. Thus, Jordanian banks pay particular attention to IFRS and risk management in order to achieve profitability through financial disclosure.
AcknowledgmentThe publication of this research has been supported by the Deanship of Scientific Research and Graduate Studies at Philadelphia University – Jordan.
Local corneal UVA crosslinking used for corneal ulcer treatment in a child. A clinical case
Authors: Mamakaeva I. R. , Pleskova A. V. , Iomdina E. N. , Katargina L. A.
Published: September 2022

Purpose: to evaluate the results of corneal ultraviolet (UVA) crosslinking used in the complex treatment of recurrent corneal ulcer in a child. Patient K., 6, was treated in the department of children eye pathology with the diagnosis of corneal ulcer. The case history said the patient was sick for 2 years, periods of remission alternated with exacerbation. Immunological examination revealed sensitization to herpes simplex virus types 1 and 2 (IgG = 3.2 with the norm of < 0.18). The combined treatment included drug therapy and local UVA crosslinking of the cornea (7 procedures per 6 minutes every other day). Optical coherence tomography showed positive changes during treatment: the depth and area of cornea infiltrate became smaller. 1 month after the last procedure, the inflammatory process was stopped and the corneal clarity gradually restored whilst vascular activity became less intense. After 2 months, the infiltrate area became clear throughout. OCT revealed a gradual decrease of the infiltrate thickness and a replacement of the cornea with a transparent tissue.

Conclusion. Local corneal UV-crosslinking used as part of the complex treatment of keratitis and corneal ulcers in children is a very promising method for implementation in clinical practice.
Recurrent cavernous orbitocranial hemangioma. A clinical case and a literature review
Authors: Serova N. K. , Trunova A. P. , Grigoreva N. N. , Cherkaev V. A. , Nazarov V. V.
Published: September 2022

Cavernous hemangioma of the orbit (CHO) is a vascular space-occupying lesion that develops as a result of an abnormal anlage of the vascular system and occurs in 70% of patients with vascular neoplasms of the orbit. CHO is more often considered as a venous malformation with slow blood flow, rather than a benign tumor. Very rarely CHO spreads into the cranial cavity, usually through the upper orbital fissure and the optic canal. The recurrence of CHO after its complete removal is low, however no reliable data are available. It is supposed that CHO relapse can occur in three cases: the continued growth of an incompletely removed tumor, growth of an undiagnosed space-occupying formation, and the emergence of a new tumor. The purpose of the study is to present a clinical case of a multiple recurrence of orbitocranial cavernous hemangioma. The clinical case demonstrates such a recurrence after an incomplete CHO removal, which was manifested by exophthalmos and moderate oculomotor disorders. Special features of the clinical case also include CHO spread into the cranial cavity accompanied by a cavernous hemangioma of the brain structure.
Significance of dyslipidemia for primary open-angle glaucoma
Authors: Erb C. , Kim A.
Published: September 2022

Reduction of intraocular pressure is currently considered as the main strategy to stop or slow down the progression of glaucomatous optic neuropathy. However, this goal is achieved in only 1 in 7 patients with primary open-angle glaucoma (POAG). Therefore, it is important to determine further risk factors that can be therapeutically influenced. One example of such risk factors is lipid metabolism disorders. Material and methods. Literature search in PubMed using the queries “primary open-angle glaucoma” and “dyslipidemia” limiting oneself to the period from 2000 to 2021. Results. POAG is currently considered to be a systemic neurodegeneration with neuroinflammation at the forefront. Oxidized low density lipoprotein (oxLDL) acts as a free radical (so-called bioactive lipid) with pro-inflammatory properties and promotes glaucomatous neuroinflammation. Conclusion. In addition to a personalized targeted pressure-oriented intraocular pressure reduction, LDL-associated lipid metabolic disorders should be corrected in every POAG patient. LDL cholesterol below 100 mg/dl (2.6 mmol/l) in the blood is the critical threshold level.