bluuebunny/crossref_metadata_2025 huggingface dataset:
DNA damage and primordial follicle activation after in vitro culture of sheep ovarian cortex in Morus nigra leaf extract
Authors: Gouveia Bruna B. , Barberino Ricássio S. , Menezes Vanúzia G. , Macedo Taís J.S. , Cavalcante Agnes Y.P. , Gonçalves Rodrigo J.S. , Almeida Jackson R.G.S. , Matos Maria Helena T.
Published: March 2019

ABSTRACT: This study evaluated the effect of Morus nigra leaf extract, with or without supplementation, on morphology, activation and DNA damage of preantral follicles cultured within sheep ovarian tissue. Ovaries were collected and divided into fragments, being one fixed for histological and Terminal deoxynucleotidyl transferase (TdT) mediated dUTP nick-end labeling (TUNEL) analysis (fresh control). The remaining fragments were cultured for 7 days in alpha minimum essential media (α-MEM) supplemented with bovine serum albumin (BSA), insulin, transferrin, selenium, glutamine, hypoxanthine and ascorbic acid (α-MEM+; control medium) or into medium composed of M. nigra extract without supplements (0.1; 0.2 or 0.4mg/mL) or supplemented with the same substances described above for α-MEM+ (MN 0.1+; 0.2+ or 0.4+mg/mL). Then, tissues were destined to histological and TUNEL analysis. The α-MEM+ treatment had more morphologically normal follicles than all M. nigra extract treatments. However, α-MEM+ treatment also showed signs of atresia because the percentage of TUNEL positive cells was similar in α-MEM+ and in 0.1mg/mL M. nigra without and with supplements. Moreover, a reduction in the primordial follicles and an increase in the growing ones were observed in all treatments, except 0.2mg/mL M. nigra. In conclusion, the follicles cultured at 0.1mg/mL M. nigra extract were in good condition and able to continue their development, as demonstrated by the same rates of DNA damage and follicular activation as the control medium.
Jürgen Döbereiner: a life dedicated to science
Authors: Dutra Iveraldo S. , Colling Axel , Driemeier David , Brito Marilene F. , Ubiali Daniel G. , Schild Ana Lucia , Riet-Correa Franklin , Barros Claudio S.L.
Published: March 2019

ABSTRACT: Dr. Jürgen Döbereiner was born in Germany, on the 1st of November 1923, and lived in Brazil for 68 years during which time he developed a range of scientific projects in veterinary pathology and related disciplines. His main interests were the identification of new poisonous plants and mineral deficiencies and the causes of “cara inchada” (“swollen face” a periodontal disease) and botulism in livestock. This research has resulted in the improved health and saving of hundreds of thousands of animals, mainly cattle, annually, and is consequently of enormous economic value to the country. This contribution remains largely under appreciated. He was also involved in organizing diagnostic methods for identifying infectious diseases such as African swine fever and glanders in horses. One of his other major achievements has been the foundation and editing of specialized scientific journals for the documentation of veterinary science research results. At the beginning of his career in the 1950s, he and colleagues from the Institute for Animal Biology (IBA) were struggling to find a national scientific journal where research results from veterinary medicine could be published with practical application to the Brazilian reality. In consequence, the team founded “Arquivos do Instituto de Biologia Animal” and published three volumes (1959-1961). He then founded and edited “Pesquisa Agropecuária Brasileira” (The Brazilian Journal of Agricultural Research”) that included a veterinary section. A series of veterinary volumes were published (1966-1976). Finally, in 1978 he helped create the Brazilian College of Veterinary Pathology (CBPA) that published “Pesquisa Veterinária Brasileira” (The Brazilian Journal of Veterinary Research) from 1981. The main goal was to communicate the most relevant disease problems of Brazilian livestock, in particular pathology and related subjects such as epidemiology, clinical study series and laboratory diagnosis to field veterinarians and academics. Dr. Jürgen Döbereiner was president of CBPA (1978-2018) and chief editor of “Pesquisa Veterinária Brasileira” (1981-2018). He passed away on the 16th of October, 2018, at the age of 94 at his home in Seropédica/RJ, Brazil.
Last chance for a big bath: managing deferred taxes under IAS 12 in Brazilian listed firms
Authors: Rathke Alex A. T. , Rezende Amaury José , Antônio Rafael Moreira , Moraes Marcelo Botelho C.
Published: March 2019

ABSTRACT This study investigates whether Brazilian loss-making firms manage deferred income tax as a form of big bath strategy. "Big bath” is a strategy in which a firm manages earnings by intentionally recording large non-recurring losses. We found original evidence supporting the hypothesis of big bath through the managing of deferred taxes under CPC 32/IAS 12. Deferred tax expenses can be used as a tool for reducing earnings because of the subjectivity and timing involved. To analyze the excess of deferred taxes, we propose a particular research strategy that is based on the increased homogeneity of accounting standards and tax regulation in Brazilian listed firms. This analysis provides new evidence of big bath adjustments that was never described before in the literature. We analyze 226 Brazilian listed firms for the 2011-2015 period. We designed a linear model to estimate deferred tax excess that is based on the conditional independence between treatment and effect under accounting standard CPC32/IAS 12. For our baseline analysis, we used least squares with controlling covariates. We also used two-stage least squares to control for omitted variables bias. This paper finds evidence that Brazilian firms can manage deferred income tax as a form of big bath. Results indicate that loss-making firms disclose significantly higher excesses of net deferred tax expenses, and that these excesses increase with losses.
Prevalence of otological symptoms and parafunctional habits in patients with temporomandibular dysfunction
Authors: Leão Bianca Lopes Cavalcante de , Gabriel Flavia Carolina Trentini , Cruz Kaliane Rodrigues da , Kagawa Amanda Luquesi , Zeigelboim Bianca Simone , Stechman-Neto José
Published: March 2019

ABSTRACT Objective: to verify the relationship between otological symptoms and parafunctional habits in individuals with temporomandibular joint dysfunction. Methods: evaluations were based on the clinical records of 768 patients treated at a temporomandibular joint diagnostic center from 2010 to 2016. The inclusion criteria were completely filled out charts of adult patients (> 18 years of age) and the final sample comprised 516 clinical records. The presence/absence of parafunctional habits and otological symptoms (tinnitus, hearing impairment, dizziness, the sensation of plugged ears and imbalance) was recorded. Results: statistically significant associations were found between otological symptoms and both sex and the presence of parafunctional habits, as otological symptoms were more prevalent among women and individuals with at least one parafunctional habit. Conclusion: in the present sample, otological symptoms were positively associated with parafunctional habits in individuals with temporomandibular joint dysfunction.
Língua Mata Virgem Brasílica: um perspectivismo dos saberes transversos
Authors: Torelly Gabriel , Zordan Paola
Published: March 2019

Resumo: Apresenta-se um conjunto de recorrências discursivas em torno do problema da exterioridade americana, evidenciando linhas de força de um imaginário e de uma linguagem que constituem dispositivos coloniais. Como estratégia metodológica, assinala-se modos pelos quais a imagem da Imaculada Conceição é dada numa fulguração figurativa, rompendo o estatuto empírico do dado histórico para ensejar a transversalidade de uma apreciação perspectivista. Tal percurso se dá junto ao pensamento de Gilles Deleuze e Félix Guattari e das perspectivas animistas estudadas por Eduardo Viveiros de Castro, a fim de discutir as tensões antropológicas do que, em nossas poéticas, chamamos de idolatria iconoclasta.
Uma Intervenção Urbana Performativa: deslocamentos de um bufão
Authors: Ferreira André Luiz Rodrigues
Published: March 2019

Resumo: O artigo objetiva investigar a ação Bassibus, criada e executada pelo bufão contemporâneo Leo Bassi, que transita por temas e problemáticas que afetam o lugar da cidade e a seus habitantes. Ação que parodia a atividade turística, o Bassibus promove com seus participantes uma dinâmica de ocupação da cidade e o questionamento sobre as forças que nela incidem. Conclui-se que essa práxis de Bassi cria um fenômeno artístico que tangencia o político como processo intersubjetivo de reconfiguração do perceptível e do pensável, carregando um chamado de enfrentamento e resistência, tanto ao artista como ao espectador/participante, em face dos dispositivos de captura e expropriação do desejo.
Role of Targeted Therapy and Immune Checkpoint Blockers in Advanced Non-Small Cell Lung Cancer: A Review
Authors: Abdel Karim Nagla , Kelly Karen
Published: March 2019

Advanced non-small cell lung cancer (NSCLC) is a complex disease comprising molecularly distinct tumor types, each with a unique biology that is becoming increasingly better characterized. The aim of this review is to present an optimized treatment schema and the accompanying diagnostic testing approach for patients with advanced NSCLC. There are a number of therapies currently approved for patients with advanced NSCLC, including agents that target particular oncogenic drivers, as well as immune checkpoint blockers (ICBs) that elicit an antitumor response. Identification of genetic alterations (e.g., epidermal growth factor receptor, anaplastic lymphoma kinase, reactive oxygen species proto-oncogene 1, B-Raf proto-oncogene) or programmed cell death ligand-1 expression levels in NSCLC requires diligent molecular testing at initial diagnosis and, in some cases, at disease progression to ensure the most efficacious treatment is delivered. Accurate molecular diagnostic testing, along with the careful selection of currently approved targeted agents, ICBs, or systemic chemotherapy, provides therapy that is personalized according to patients’ needs to achieve the best possible outcome. Enrollment in clinical trials that further the development of tailored therapies is highly recommended at all stages of treatment.

Implications for Practice

Targeted therapies and immune checkpoint blockers provide effective and tailored options for patients with non-small cell lung cancer. Careful molecular analysis of tumor samples is necessary to identify the genetic alterations that are present, to ensure that each patient receives the most efficacious treatment for their specific tumor type. Personalized therapy provides each patient with the best probability for prolonged survival. Enrolling patients in clinical trials should be the first consideration before making each treatment decision.
Employment of Vocational Graduates: Still a Slough or Already a Ford?
Authors: Dudyrev Fedor , Romanova Olga , Travkin Pavel
Published: March 2019

The study is devoted to employment of recent vocational graduates. The pro­portion of middle-school graduates in vocational enrollment has increased es­sentially over the past decade, which indicates that the choice of vocational trajectories, on average, is now made at lower age. It was established based on the Monitoring of Education Markets and Organizations that on average 44 percent of students combined work and study in 2010–2015. Vocational students mostly combine and work and study because of financial constraints, their study-work rarely being related to their major. Later on, when making a transition from education to the labor market, vocational graduates have to ac­cept one of the first job offers as they cannot afford a longer job search. The second part of the study draws upon the findings from the 2010–2015 sam­pling survey of graduate employment administered by the Federal State Statistics Service (Rosstat). It is shown that combining work and study has posi­tive effects on employability of graduates as well as on the size of their starting salaries. In addition, self-funded students and those who combine study with major-related work are more likely to get employed in their field of study af­ter graduation. Education-job mismatch among graduates is found to entail income “penalties”.
Human Being and Lifeworld: From Ontology to Phenomenology
Authors: Leontiev D.A.
Published: March 2019

The paper is focused on one of the key aspects of Fyodor Vasilyuk’s contribution to the elabora¬tion of methodological foundations of psychology, namely, on the construct of lifeworld and ‘lifeworld ontology’ as a metatheoretical framework for the understanding of human life and activity in the world. The paper is subdivided into four sections. The first one gives the justification of Vasilyuk’s approach in terms of ‘lifeworld ontology’, reveals its conceptual connection with the ideas of A.N. Leontiev and S.L. Rubinstein. The second one is dedicated to the concept of lifeworld, its association with specifically human ways of existing in the world, its distinction from the environment and the idea of multiple hu¬man worlds. In the third section, the author reveals, basing on the conceptions of L. Binswanger, E. van Deurtzen and C. Popper, the multidimensional structure of human lifeworld and discusses the mutuality of human-world relationships. In the fourth section. a typology of lifeworlds is offered, based on three core criteria: past/present/future ratio, individual/society relationship, and factual/due/possible ratio as value orientations.
Psychotechnical Theory as a Format of Psychological Knowledge
Authors: Patyaeva E.Y.
Published: March 2019

The paper deals with the methodological characteristics of psychotechnical theory, a specific format of psychological knowledge developed by F.Ye.Vasilyuk. The author describes the general logic of overcoming the ‘schism’ in psychology through the discovery of the methodological importance of psychological practice. It is also shown that the philosophy of practice is implemented through the psychotechnical approach, its crucial feature being the investigation not of the mind per se, but of the experience of working with the mind. The format of psychological knowledge appropriate for the psychotechnical approach is the psychotechnical theory. Eight methodological characteristics of the psychotechnical theory suggested by F.Vasilyuk create a certain conceptual space fitted not only for psychotechnical theories, but also for classical ‘academic’ theories as well as various mixed ones. The article concludes that the psychotechnical theory presents a more general and universal format of psychological knowledge in comparison with the classical theories, and this means an opportunity to create a unified methodological tool for describing and analyzing psychological research and practice — and thus for overcoming the schism in psychology.
Digital Platforms and International Private Law, or Is There a Future for Cyber Law?
Authors: Mazhorina M. V.
Published: March 2019

Modern economy and society are reconfigured in connection with the emergence and development of digital platforms, which is figuratively referred to as “uberization of everything”. This became possible with the development of information and communication technologies and the formation of cyberspace. The key problem for lawyers is the construction of the legal superstructure of cyberspace, which leads to the emergence of a number of concepts: cyberlaw, “platform law”, internet law etc. However, while science is trying to comprehend the relevant paradigm shifts, a huge array of cross-border transactions are made by consumers with platformtype companies; cross-border disputes are resolved through online dispute resolution (ODR) procedures in international commercial arbitration or courts; law enforcement practice is being formed, which responds to the challenges of the cyber environment. It is the tools of private international law that are most in demand in regulating the relevant relations. What would be more viable in modern conditions: international private law or cyber law?
Criminal Responsibility for Collusions at Auctions
Authors: Danilovskaya A. V. , Tenishev A. P.
Published: March 2019

The anti-monopoly practice concerning agreements prohibited by the Federal Law “On Protection of Competition” traditionally defines the so-called collusions at tenders. Depriving the state of the opportunity to save budget funds, collusions at auctions do not only violate the procedure established by the law, but, by limiting competition, adversely affects the country’s economy.

For collusion at an auction, both administrative (Article 14.32 “Conclusion of an agreement restricting competition, the implementation of concerted actions restricting competition, coordination of economic activities” of the Administrative Code of the Russian Federation) and criminal responsibility (Article 178 “Restriction of competition”, as well as Articles 159, 285, 286 of the Criminal Code of the Russian Federation) is set.

However, the current version of Article 178 of the Criminal Code of the Russian Federation, which is supposed to be the main one in the fight against anti-competitive agreements, has significant drawbacks that make the fight against these dangerous anti-competitive agreements ineffective. The damage from the activities of all cartels (in the commodity markets, during the procurements by state-owned companies and the state, during the bidding for the alienation of state property) is estimated at 1.5-2% of GDP.

Meanwhile, when carrying out public procurement and procurement of companies with state participation consume up to 30 trillion rubles a year. If the bidding is held under collusion, the reduction in the initial (maximum) contract price hardly reaches 1%; if the bidding is held in a competitive environment, the price decline reaches 20-30%. Perhaps not so obvious, but this does not mean that the collusion at auctions has a negative effect on competition. Companies compete neither in price nor in quality. Access to the state order, and therefore, an undoubted competitive advantage in the commodity markets, is obtained not by those companies that are better and more efficient, but by those that have been able to come to an agreement. Only in 2016, due to the low level of competition in trading, the budgets of all levels lost more than 180 billion rubles. Moreover, the Federal AntiMonopoly Service (FAS) considers this number underestimated — the application of the methodology adopted in OECD countries brings the figure of damage up to 1 trillion rubles per year.

The current situation requires an appropriate response, in particular, introducing changes into the legislation of the Russian Federation that reflect the substantially increased public danger of anti-competitive agreements and will also contribute to the development of the practice of countering them.
Recognition of right as a way to protect liability rights
Authors: Starovoytova A. S.
Published: March 2019

The article substantiates the conclusion that recognition of the right is a universal way of protection of civil rights. This method of protection can be applied to liability rights. The article reveals the practical application of recognition of right as a way of protecting liability rights. The author states that the requirement to recognize the contract as concluded is a claim to recognize the obligations legal relationship. The structures similar to the recognition of liability rights are analyzed and the conclusion that such requirements are not claims for recognition, but are claims for award is reasoned. Claims for recognition of obligations are recommended to be divided into positive and negative. Particular attention is given to the legal design of the claim on recognition of obligations rights. In particular, the issues of the subject of the claim, its subjects, the conditions of presentation and satisfaction of the claim were considered. The claim for recognition of the right of obligation in its subject matter should be qualified as a requirement for confirmation of legal relationship.
”Non-freedom” of a contract and unfair contractual terms in the practice of state and municipal procurement
Authors: Tasalov F. A.
Published: March 2019

The majority of contemporary studies devoted to the freedom of contract is devoted to the peculiarities of implementation of this principle in commercial relations. The article analyzes the other side of the freedom of contract — its application in state and municipal procurement. The author analyzes conclusions drawn in Resolution of the Plenum of the Supreme Court of the Russian Federation of March 14, 2014 No. 16 “On freedom of contract and its limits” on the basis of court disputes between public procurement authorities and suppliers within the framework of the Federal Law of April 5, 2013 No. 44-FZ “On the contract system in the procurement of goods, works and services for state and municipal needs.” The paper determines the key features of the principle of freedom of contract at the stage of determining the supplier and at the stage of performance of obligations under procurement contracts. Special attention is paid to the assessment of negotiation opportunities, public procurement authorities and participants of procurement, the problem of abuse of the right by a stronger party depending on the starting conditions of the purchase and the ways of its implementation by the public procurement authority. The analysis of arguments of courts concerning interpretation of terms of procurement contracts from the point of view of freedom of contract and its limits is presented. To sum up, the author provides for practical recommendations and conclusions.
Deposit insurance systems in the European union: legal regulation and development prospects
Authors: Alsov N. M.
Published: March 2019

The paper provides a historical, substantive and functional analysis of the legal regulation of deposit insurance systems (hereinafter referred to as DIS) in the European Union based on Directive 2014/49 / EC of the European Parliament and of the Council of April 16, 2014. “On Deposit Insurance Systems” (revised). The author considers the contribution of DIS to improving the financial stability of the EU banking sector. The paper shows a conducted assessment of the measures implemented and planned for implementation initiated by the European Commission and the European Central Bank for the implementation of a single European DIS as the third pillar of the Banking Union. The author concludes that the third Directive “On DIS” allows for a qualitative step forward towards the creation of the third pillar of the Banking Union. Despite some unresolved and controversial issues, it creates uniform rules of the game for national DIS in a deposit insurance policy. Further development and movement towards European DIS will make it possible to increase the effectiveness of the EU deposit insurance policy by reducing costs, overcoming administrative barriers in national DISs, increase the level of protection of depositors’ rights, and strengthen confidence in the banking sector and its stability.
Relationship between Organizational Trust and Organizational Innovation: Case Srudy of the Payam Nour University
Authors: Jamshidi Ali
Published: March 2019

The present research was done to analyze the relationship between organizational trust and organizational innovation at Payam Nour University in Tehran Province. To collect data related to organizational trust, Payne questionnaire was used. Organizational innovation data were collected by a researcher-developed questionnaire. The reliability of both of which based on Alfa Cronbach coefficient was 91% and 86% respectively. To analyze data, Pearson correlation test and step-by step regression were applied. The result of correlation test showed that there is positive and significant relationship between organizational trust and all its dimensions with organizational innovation. The results of structural equation modeling were collected by 231 questionnaires and suggest that innovative leadership and organizational trust have relation with organizational innovation. In conclusion, the result is analyzed and some suggestions are made to improve innovation capability in the organization of the target population.
The Contradictory Views on Ancient Literary Works as a Foundation of World Historical Development
Authors: Yaacob Solehah , Haron Ismail
Published: March 2019

Contradictory views on ancient literary works provide a panorama of historical development. However, the validity of the texts was considered as issue of prime importance. The critics on its literary authenticity would reveal whether it was real or just a fabrication. The Epic Gilgamesh was ascertained by Said Ghanimi to be unauthentic. The contentions by S. N. Kramer and Taha Baqir were with regard to the differences of language usage in the Epic Gilgamesh either Sumerian or Akkadian as well. The acknowledgment of the West on Iliad and Odyssey by Homer as the first document written in world history was unfounded although this was highlighted by B. Lansberger in 7thconference in Paris on 1958. The Code Hamurabbi is a well preserved Babylonian Code of laws, unfortunately, it was considered as a fabrication of Old Testament which came 800 years later, especially on the narration of Big Flood Story as mentioned in the Book of Genesis. It is regrettable that the paucity of materials on the ancient history of the ancient people available from the Muslim sources poses as constrain on this study. The research is compelled to refer almost entirely to Western and Jews sources. Thus, the approach used in this study is based primarily on historical and linguistic analysis of ancient literary works.
A Cura pela Fé: um diálogo entre ciência e religião
Authors: Pereira Valdelene Nunes De Andrade , Klüppel Bergta Lúcia Pinheiro
Published: March 2019

Este trabalho analisa a influência da religiosidade sobre a saúde de 139 indivíduos hipertensos, acompanhados em uma unidade do Programa Saúde da Família de Pedras de Fogo (PB). Distribuídos em dois grupos de acordo com a freqüência a serviços religiosos, percebeu-se que os mais religiosos evoluíram melhor quanto aos sintomas clínicos. Ademais, relatos apresentados levam à conclusão que a religiosidade é benéfica para a saúde geral das pessoas, podendo ser usada como ferramenta terapêutica complementar, inclusive na abordagem em saúde mental.
O Que é Diversidade Religiosa, Afinal? E você, o que tem com isso?
Authors: Cavalcanti Carlos André
Published: March 2019

Um preceito é crucial e básico: a liberdade de expressão religiosa, base da Diversidade, não pode permitir os ataques entre as religiões ou destas a não religiosos ou ainda destes às próprias religiões, posto que são EXATAMENTE estes ataques o objeto da nossa militância e da cultura universal pela paz. A sua relação com este assunto, caro(a) leitor(a), está principalmente na garantia do respeito aos seus direitos fundamentais. O Ensino Religioso vive um período longo de transição e deverá tornar-se a ponta de lança da Diversidade Religiosa na formação do cidadão no Brasil. Há muito deixou de ser, pela lei, o ensino da pregação religiosa. O conhecimento da História e das Ciências das Religiões não deve ser subestimado para a aplicação dos Direitos Humanos como conhecimento capaz de ensejar a inclusão social através do Ensino Religioso, que é demanda própria da escola.
Salud ocupacional en dos centros de clasificación y acopio de materiales reciclables en el Área Metropolitana de Buenos Aires, Argentina, 2015
Authors: Mastrangelo Andrea , Schamber Pablo
Published: March 2019

¿Cómo estimar los riesgos para la salud de las y los trabajadores que manipulan residuos sólidos urbanos separando y clasificando materiales reciclables? Para responder esta pregunta, durante 2015, se realizó una investigación en terreno con una perspectiva ecoepidemiológica en dos centros de clasificación y acopio (uno urbano y otro en un descampado periurbano) ubicados en la zona sur del Área Metropolitana de Buenos Aires, Argentina. Con el propósito de describir el proceso de trabajo, se utilizaron técnicas etnográficas (entrevistas, observación participante), proyectivas y de trabajo corporal, para caracterizar las condiciones y medio ambiente según riesgos y exigencias de la Organización Internacional de Trabajo para este trabajo no clásico. Las exigencias tenderían a concentrarse en el ingreso y salida de materiales, los riesgos del objeto de trabajo resultarían de la separación y, los riesgos biológicos, del ambiente de trabajo. Se encontró diversidad y poca planificación en el proceso de trabajo. Por ello, la caracterización de las condiciones y el medio ambiente de trabajo fue también una instancia de reflexividad entre trabajadores e investigadores sobre la creación-organización del ambiente de trabajo y la corporización de los padecimientos.
Investigating Acceptable Level of Travel Demand Before Capacity Enhancement for Signalized Urban Road Networks
Authors: BAŞKAN Özgür , CEYLAN Hüseyin , OZAN Cenk
Published: March 2019

Increasing travel demand in urban areas triggers
traffic congestion and increases delay in road networks. In this context, local
authorities that are responsible for traffic operations seek to strike a
balance between traffic volume and capacity to reduce total travel time on road
networks. Since intersections are the most critical components of road networks
in terms of safety and operational issues, adjusting intersection signal
timings becomes an effective method for authorities. When this tool remains
incapable of overcoming traffic congestions, authorities take expensive
measures such as increasing link capacities, lane additions or applying
grade-separated junctions. However, it may be more useful to handle road
networks as a whole by investigating the effects of optimizing signal timings
of all intersections in the network. Therefore, it would be useful to
investigate the right time for physical improvements on the road network to
avoid premature investments considering limited resources of local authorities.
In this study, effects of increasing travel demand on Total Travel Cost (TTC)
is investigated by developing a bi-level programming model, called TRAvel COst
Minimizer (TRACOM), in which the upper level minimizes the TTC subject to the
stochastic user equilibrium link flows determined at the lower level. The
TRACOM is applied to Allsop and Charlesworths’ network for different
origin-destination demand matrix multipliers. Results revealed that TTC values
showed an approximate linear increase while the travel demand is increased up
to 16%. After this value, TTC showed a sudden spike although the travel demand
was linearly increased that means optimizing signal timings must be supported
by applying psychical improvements.
A iniciação científica e a relação com a formação profissional
Authors: Simao Cinthia Carla de Oliveira , Dominschek Desiré Luciane , Lima Janaina Silva Teixeira de , Bitencout Sabrina Pindziura , Both Ivo
Published: March 2019

Esta pesquisa trata, em linhas gerais, da formação de professores compreendendo as dimensões: (i) da iniciação da formação do professor pesquisador; (ii) da aproximação com a prática profissional do docente em instituições educativas, escolas e outras; (iii) da relação entre pesquisa e profissionalização do professor; (iv) das práticas de pesquisa realizadas pelos professores em seu trabalho. A investigação a ser realizada focaliza as séries finais de formação (graduação) e anos iniciais de trabalho procurando estabelecer relações entre formação em pesquisa e suas implicações com a profissionalização do professor. As principais referências internacionais desta pesquisa são: NÓVOA, A. (1992); CARR, W. (2004) e as principais referências nacionais desta pesquisa são; GATTI, B. A. (2006, 2009). Considerando o alcance e significado dos programas de incentivo de fomento à formação do professor, urge indagar a respeito dos impactos desses programas na profissionalização docente. Nesse sentido, a questão básica desta investigação é: “quais são os impactos dos projetos de incentivo à pesquisa no desenvolvimento profissional?” O objetivo desta pesquisa é compreender o impacto dos projetos de iniciação à pesquisa ofertados nos cursos de formação docente aos professores ao longo de sua experiência profissional. Optamos, metodologicamente, por uma abordagem qualitativa, que tenha como escopo as perspectivas fenomenológica e histórico-crítica.
Modern dance
Authors: Silva Fernando Vitor da , Vitiello Julia Ziviani
Published: March 2019

The objective of this research is to invesigate the innovation process in dance and theatre production in São Paulo, as initiated by two pioneer artists of modern dance, Ruth Rachou and Renée Gumiel. A study of the history of dance in São Paulo, starting from the founding of the IV Centenary Ballet, the country's first professional dance company, including an analysis of the emergence of modern dance in Brazil's largest city and how the cultural scene was affected by the innovative work done by these artists, primarily in theatre.
Influência da sinvastatina sobre a expressão de marcadores de células-tronco neoplásicas e de marcadores inflamatórios em linhagem de carcinoma mamário humano
Authors: Mendonça Íris Balero de , Mazon Silvia de Barros , Davoli Katia Jaqueline , Souza Valéria Barbosa de , Silva Izabel Crivelli Nunes da , Schenka André Almeida
Published: March 2019

As células tronco neoplásicas (CTNs) são células presentes no tumor com características de autorrenovação e autodiferenciação semelhantes às das células tronco adultas (CTs). A inflamação é um processo que ocorre nas neoplasias e pode acentuar os desequilíbrios no microambiente tumoral, podendo colaborar com o aumento da proporção de células com fenótipo de CTNs. Considerando as propriedades antiinflamatórias das estatinas, existe a possibilidade de modulação da resposta inflamatória estar relacionada aos efeitos antineoplásicos desse grupo de fármacos. O presente trabalho avaliou as ações da sinvastatina sobre a expressão de marcadores de CTNs (CD24, CD44) e de marcadores inflamatórios (TNF-α, IL-6 e IL-1β) em linhagem de carcinoma mamário humano (MCF-7). Utilizando as técnicas de imunocitoquímica e de citometria de fluxo, as análises foram feitas em triplicata, comparando-se grupo de células não tratadas, com grupo tratado com sinvastatina e grupo tratado com doxorrubicina (controle positivo). O tratamento com sinvastatina demonstrou redução expressiva dos marcadores CD24 e CD44 na análise por imunocitoquimica e do perfil CD44high/CD24low/negative pela citometria de fluxo, mas redução muito discreta de TNF-α. Concluindo-se que, nas condições experimentais da presente investigação, a sinvastatina demonstrou ação reguladora sobre o fenótipo CD44high/CD24low/negative em cultura de células MCF-7, mas efeito muito modesto sobre a expressão de TNF-α.
A busca pela preservação digital
Authors: Rosa Juliana Dias da , Dominschek Desiré Luciane , Cobbe Rafael , Matunaga Claudeiza Labes Chaves , Lopes Jackson Francisco
Published: March 2019

Este trabalho buscou apresentar o debate ético e o compromisso institucional quanto a preservação documental digital de uma instituição de ensino superior. Nossa análise identifica os arquivos como lugares de memória, onde o historiador/pesquisador encontra seus documentos , os questiona, os interroga e os transforma em suas fontes. Entendemos que as fontes não falam por si, assim como por si não se tornam documento; o que as fontes transmitem confronta-se com a subjetividade ou a objetividade do historiador/pesquisador. A realidade do passado e a intencionalidade do historiador necessitam de um aporte teórico de conceitos e procedimentos, e estes procedimentos e conceitos, precisam ser balizados pelo comprometimento ético do pesquisador, na construção da verdade histórica preservada. Identifica-se a relevância deste estudo para a área de história e para a ciência na medida em que o objetivo norteador do trabalho foi apresentar o arquivo enquanto espaço de memórias e que produz memórias e histórias a partir da intencionalidade do historiador. Além disso, fazer emergir a narrativa deste arquivo enquanto local de preservação da memória de instituições, é destacar a intencionalidade dos percursos históricos que podem emergir a partir de pesquisas científicas. Esta pesquisa , recorre a pesquisa documental em uma análise qualitativa, problematizando a preservação digital de documentos institucionais.
As bases institucionais da política de extensão universitária
Authors: Ribeiro Raimunda Maria da Cunha
Published: March 2019

A política de extensão universitária tem como princípio promover a comunicação entre a universidade e a comunidade, cuja finalidade é a divulgação do conhecimento. Partindo deste pressuposto, adotamos como objetivo neste estudo, analisar a política de extensão de universidades públicas federais, tendo como base as orientações declaradas nos Planos de Desenvolvimento Institucional. A metodologia adotada foi a abordagem qualitativa, embora apareçam dados em percentuais, mas como a análise não resulta em um aprofundamento estatístico propriamente dito, dizemos que se trata de uma pesquisa, predominantemente, qualitativa. A técnica de coleta de dados baseou-se nos princípios da análise documental, adotando como objeto os Planos de Desenvolvimento Institucional de 27 universidades federais, com sede nas capitais. A síntese conclusiva aponta para o seguinte entendimento: a política de extensão na universidade pública brasileira, conforme está posta nos documentos, remete ao cumprimento da função social e educacional, de formação acadêmica, com a implementação de ações de caráter teórico-prático para a promoção do conhecimento e da cultura, do acesso ao saber e à solidariedade humana, de forma participativa, dialógica e de valorização de parcerias.
Potencialidades das visitas técnicas na docência universitária
Authors: Santa Anna Jorge
Published: March 2019

A prática educativa realizada nas instituições de ensino superior representa uma atividade louvável, sobretudo por proporcionar, sobremaneira, a formação profissional. Embora constitua um fazer de suma importância, desafios não deixam de permear a docência universitária, o que requer a constante reformação dos métodos de ensino adotados nas salas de aula. Portanto, este texto aborda o potencial das visitas técnicas, consideradas como métodos inovadores de ensino, e os reflexos por elas promovidos quando aplicadas em disciplinas de cunho técnico-operacional, no Curso Superior de Biblioteconomia. Também apresenta fundamentos teóricos sobre docência universitária, algumas características das visitas técnicas e reflexões a respeito do ensino superior de Biblioteconomia - com foco nas disciplinas de Representação documentária. Trata-se de um estudo descritivo, de natureza qualitativa, sendo conduzido por meio de uma pesquisa participante realizada em duas disciplinas de Biblioteconomia: Representação Descritiva I e II, cuja técnica utilizada na coleta de dados foi a observação direta. A fim de fortalecer as evidências coletadas, o estudo também estabelece diálogos com a literatura, por meio de pesquisa bibliográfica. Constatou-se que as visitas técnicas funcionam como instrumentos pedagógicos que provocam a motivação e engajamento dos participantes com o aprendizado, como também promovem a identificação e a visibilidade das práticas de catalogação em acervos bibliográficos. Em síntese, as visitas muito contribuem com o lecionamento de disciplinas técnicas, como a catalogação de documentos, proporcionando a fusão entre teoria e prática; entre sala de aula e mercado de trabalho.
A prática pedagógica colaborativa
Authors: Ruiz Sofia Maria de Araújo , Gebran Raimunda Abou
Published: March 2019

Este artigo apresenta o processo e os resultados de uma pesquisa-ação colaborativa com docentes do Curso de Administração de uma universidade pública. O objetivo centrou-se em analisar a prática pedagógica colaborativa na educação superior, investigando suas dificuldades/limitações e seus avanços, bem como o contexto no qual ela ocorre. A questão que se pretendeu responder foi se havia possibilidades de desencadear um processo de repensar a prática docente a partir de ações colaborativas num grupo com características de trabalho individualizado, visando à melhoria qualitativa no processo formativo dos alunos e dos docentes. A pesquisa caracterizou-se como pesquisa qualitativa e foram utilizados como procedimentos entrevistas semiestruturadas com os participantes, análise documental, especificamente do projeto pedagógico do curso, dos planos de ensino, para identificar as concepções de educação e se existiam registros de trabalho coletivo; por fim, foram realizados encontros com os docentes para reflexão crítica sobre a ação colaborativa. Os caminhos metodológicos proporcionados pela pesquisa-ação crítico-colaborativa apontaram que, embora a formação de um trabalho colaborativo seja um percurso conquistado a longo prazo, esta se constituiu em uma oportunidade de aprendizagem e de desenvolvimento profissional, que os docentes participantes mostraram durante as reflexões ser possível e ser necessário. Espera-se que os caminhos metodológicos proporcionados pela pesquisa-ação crítico-colaborativa possam contribuir com a análise da prática docente e, como consequência, uma oportunidade de aprendizagem profissional; pois, a partir do envolvimento dos participantes, seja construído um trabalho mais consistente e comprometido, com vistas à melhoria do processo educativo e formador.
Educação superior e relações de gênero
Authors: Prates Solange Riato , Gonçalves Josiane Peres
Published: March 2019

O presente estudo tem por objetivo investigar a realidade de mulheres que se tornaram mães enquanto cursavam Pedagogia, com ênfase para os desafios vivenciados por elas ao conciliar os estudos com a maternidade, bem como a postura da universidade em relação às atividades domiciliares e atendimento a essas alunas. A pesquisa foi realizada por meio de levantamento de informações na Secretaria Acadêmica da universidade e gravação de entrevistas com uma professora e três mulheres que se tornaram mães enquanto estudavam Pedagogia. Os resultados indicam que: apesar de as mulheres conquistarem espaço no mundo acadêmico, quando ocorre a gravidez elas se deparam com dificuldades, ficando acumuladas de atribuições; durante os três meses de licença maternidade, os professores enviam atividades domiciliares, mas as alunas consideram pouco tempo de afastamento; apesar dos desafios vivenciados pelas 34 mães acadêmicas, 91,16% do total deram continuidade ou conseguiram concluir o curso de Pedagogia.
Internacionalização e educação para a cidadania global
Authors: Santos Pricila Kohls dos , Morosini Marília Costa
Published: March 2019

Este estudo objetiva analisar concepções de professores universitários brasileiros acerca dos princípios da Educação para a Cidadania Global (ECG) e da internacionalização da educação superior, bem como apresentar subsídios para reflexão sobre a prática docente na educação superior. O processo de triangulação de dados se consolida com a metodologia de caráter qualitativo, na medida em que foram selecionados professores do ensino superior, de diversas áreas do conhecimento, de uma Instituição de Ensino Superior comunitária da região Sul do Brasil, para coletar suas percepções acerca da formação do cidadão global. Para tal, foram utilizados como instrumentos o questionário e dois grupos focais, ambos com docentes. Nos resultados da pesquisa, destacam-se algumas proposições possíveis no sentido de fomentar as recomendações da Unesco para o desenvolvimento da ECG e tomando como ponto de partida a visão dos docentes pesquisados sobre esse novo papel na universidade. Nesse sentido, os resultados desta análise apontam: a necessidade de a educação voltar-se ao paradigma de aprendizagem; a importância da responsabilidade compartilhada dos diferentes níveis e atores da educação superior e investimento institucional em processos de internacionalização, para a formação de um cidadão global.
Optimizing Conditions for Scandium Extraction from Bauxite Residue Using Taguchi Methodology
Authors: Lymperopoulou Theopisti , Georgiou Paraskevas , Tsakanika Lamprini-Areti , Hatzilyberis Konstantinos , Ochsenkuehn-Petropoulou Maria
Published: March 2019

Bauxite residue is the voluminous by-product of alumina production after Bayer process. Its high alkalinity causes disposal problems and harmful environmental impacts. However, the residue contains significant amounts of valuable elements such as rare earth elements including scandium. Greek bauxite residue contains a high amount of scandium close to its main resources. Taking into account scandium limited availability coupled with its high demand in modern technology, bauxite residue could be considered as a potential resource for scandium recovery. In this study, the optimization of scandium extraction from bauxite residue with sulfuric acid is investigated using Taguchi methodology. Based on previous studies acid molarity, leaching time, solid/liquid ratio and reaction temperature were selected as control parameters for the selective Sc recovery. Method optimization targeted the highest concentration of scandium combined with the lowest concentration of iron without taking into account applications constraints. The predicted values resulted by Taguchi methodology were affirmed by a confirmation experiment conducted at optimal conditions. Regression analysis provided the respective equations to be applied on several conditions depending on different applications.
Comparison of Response Surface Methodology and Hybrid-Training Approach of Artificial Neural Network in Modeling the Properties of Concrete Containing Steel Fiber Extracted from Waste Tires
Authors: Awolusi Temitope F. , Oke Oluwaseyi L. , Akinkurolere Olufunke O. , Atoyebi Olumoyewa
Published: March 2019

The study presents a comparative approach between response surface methodology (RSM) and hybridized, genetic algorithm artificial neural network (GA-ANN) in predicting the water absorption, compressive strength, flexural strength split tensile strength and slump for steel fiber reinforced concrete. The effect of process variables such as aspect ratio, water cement ratio and cement content were investigated using the central composite design of response surface methodology.  This same experimental design was used in training the hybrid-training approach of artificial neural network. The predicting ability of both methodologies were compared using the  root mean sqaured error (RMSE), mean absolute error (MAE), model predictive error (MPE) and absolute average deviation (AAD). The RSM model was found more accurate in prediction compared to hybrid GA-ANN.