bluuebunny/crossref_metadata_2025 huggingface dataset:
Aporte de leche materna en el recién nacido prematuro hospitalizado y evolución nutricional
Authors: Arguello Carolina E , Defagó María Daniela
Published: September 2024

ResumenAntecedentes: El nacimiento pretérmino es una emergencia nutricional y requiere consideraciones especiales. Objetivos: Se propuso evaluar el aporte de leche humana (LH) en el recién nacido prematuro hospitalizado de bajo peso (RNP-BP) y muy bajo peso (RNP-MBP), factores maternos y su relación con parámetros nutricionales. Materiales y métodos: Participaron 87 RNP-BP y 82 RNP-MBP admitidos en un hospital público en Córdoba, Argentina. Se registró la antropometría evolutiva, alimentación, parámetros bioquímicos, antecedentes del niño y maternos. Se calculó el aporte de LH. Se analizaron los valores antropométricos y bioquímicos, días de internación y factores maternos según aporte de LH. Resultados: El 36,36% de los RNP-MBP y el 31,02% de los RNP-BP cubrió más del 20% de su alimentación con LH. La hemoglobina sérica fue superior en RNP-MBP que recibieron más LH (p=0,01). Los RNP con menos del 20% de su alimentación con LH presentaron una asociación estadísticamente significativa entre la cantidad de LH y la talla al alta hospitalaria. Se observó una elevada prevalencia de cesáreas, asociada a un menor aporte de LH.Conclusiones: El aporte de LH contribuiría a estabilizar la hemoglobina en RNP. La presencia de cesárea podría asociarse a un menor aporte de LH a los RNP. AbstractBackground: Preterm infants require special considerations than term infants to obtain adequate growth.Objective: The aim was to evaluate human milk (HM) in low birth weight premature newborn (LBW-PN) and very low birth weight (VLBW-PN) during hospitalization, maternal factors, and the relationship with nutritional parameters.Material and methods: 87 LBW-PN and 82 VLBW-PN), admitted in a public hospital in Córdoba, Argentina, were included. Anthropometry, food and biochemical parameters, and child and maternal history were registered. HM contribution was calculated. Anthropometric and biochemical values, days of hospitalization and maternal factors by HM intake were analyzed. Results: Only 36,36% of VLBW-PN and 31,02% of LBW-PN had more than 20% of their diet with HM. The hemoglobin concentration at discharge was higher in VLBW-PN group with more HM (p=0,01). There was a statistically significant association between HM amount and height at discharge in the PN with less than 20% of their diet with HM. A high prevalence of cesarean delivery was observed, related to lower HM.Conclusions: HM contributes to hemoglobin stabilization. Cesarean delivery may be associated with lower contribution of HM to newborn infants.
Hyperandrogenism produced by ovarian tumors in women at different life stages.
Authors: Fuox-Otta Carolina , Szafryk de Mereshian Paula , López de Corominas Mónica , Fuster Margarita , López Carlos R
Published: September 2024

ABSTRACT Objective: to evaluate the different presentations of hyperandrogenism produced by ovarian tumors in women at different life stages Design: case report Setting: academic institutions Patient(s): 3 patients at different life stages, with increased androgen levels Intervention(s): review of hospital records Main Outcome Measure(s): clinical and biochemical features, treatment and follow-up Result(s): a 10 year-old girl with Leydig cell tumor presented with hyperandrogenemia, virilization and changes in social behavior. Another patient, at reproductive age, with a tumor >10 cm, presented with signs of virilization and abdominal mass, whose pathologic analysis disclosed a carcinoid tumor of the ovary associated with stromal hyperplasia. The third patient was a postmenopausal woman with severe alopecia, who presented a steroid cell tumor, rare at that age. Conclusion(s): the evaluation of women with signs and symptoms of virilization should include a detailed clinical record, thorough physical examination and an appropriate hormonal dosage, especially when images are inconclusive.
Tiroidectomía total en el bocio multinodular benigno
Authors: Palas Cesar , Alvarez Facundo , Ferreira Gaston , Gramática Luis
Published: September 2024

Resumen Introducción. El tratamiento del bocio multinodular beningo (BMNB) es motivo de continuo debate en las últimas décadas pese a la evidencia de que la tiroidectomía total (TT) está relacionada a una reducción significativa en la recurrencia de la enfermedad y a una mínima morbilidad en manos entrenadas. Objetivo. Determinar la recurrencia del BMNB al cabo de 10 años en 100 pacientes tratados con TT y evaluar las complicaciones relacionadas a la técnica. Diseño. Prospectivo no randomizado. Material y métodos. Desde marzo del 1999 a marzo del 2001, cien pacientes, 95 del sexo femenino, con un promedio de edad de 42,4 años (rango: 23-67), fueron sometidos a una TT por padecer un BMNB, el cual fue confirmado por la ecografía cervical, la que además sirvió de guía para realizar la punción aspiración con aguja fina (PAAF). En todos los casos se realizó un laringoscopía inderecta pre y post postquirúrgica. Resultados. El tiempo operatorio promedio fue de 49 minutos (rango: 35-58). Registramos una parálisis recurrencial (1%) y cinco hipoparatiroidismos (5%), ambos transitorios y ningún caso definitivo. Todos los pacientes fueron dados de alta antes de las 24 horas de la cirugía. No objetivamos ninguna recurrencia del BMNB en un período de seguimiento de más de 10 años. Conclusión. La TT es el tratamiento elección del BMNB, por ser un procedimiento eficaz, seguro, con mínimas tasas de complicaciones y por evitar o reducir significativamente la recurrencia de esta enfermedad.   Summary Introduction. The treatment of  benign multinodular goiter   (BMNB) is a matter of ongoing debate in recent decades despite evidence that total thyroidectomy (TT) is associated with a significant reduction in disease recurrence and minimal morbidity in trained hands. Objective. Determine BMNB recurrence after 10 years in 100 patients treated with TT and evaluate the technique-related complications. Design. Prospective non randomized. Material and methods. From March 1999 to March 2001, one hundred patients, 95 female, with an average age of 42.4 years (range 23-67) underwent TT for having a BMNB, which was confirmed by cervical ultrasound, which also served as a guide to perform fine-needle aspiration (FNA). In all cases, laryngoscopy was performed before and after post-surgical bitstream. Results. Mean operative time was 49 minutes (range 35-58). Recurrencial recorded paralysis (1%) and five hypoparathyroidism (5%), both transient and no definitive case. All patients were discharged within 24 hours of surgery. We did not record any recurrence BMNB a follow-up period of more than 10 years. Conclusion. The TT is the treatment choice of BMNB, being an effective, safe, with low rates of complications and to avoid or significantly reduce the recurrence of this disease.
Estudios epidemiológicos sobre cáncer y herbicidas
Authors: Cuestas Eduardo
Published: September 2024

La investigación es el fundamento del progreso de la medicina, pues proporciona las evidencias sobre las que se basa la práctica clínica. Es la única forma de obtener la información necesaria sobre la eficacia y seguridad de las intervenciones diagnósticas, pronosticas y terapéuticas, como así también para el conocimiento de la etiología, la fisiopatología y los factores de riesgo de las enfermedades.La investigación reporta cuando la realizan científicos idóneos y probos, un importante beneficio social, y por ello se considera un deber moral de la medicina. El resultado de la investigación es el conocimiento, que debe publicarse luego de una pormenorizada revisión por pares independientes y sólo si éstos la aceptan para su publicación en una revista científica reconocida.Como es un proceso que está sujeto a importantes conflictos de intereses, su valoración metodológica, científica, moral y ética son fundamentales para garantizar transparencia hacia la sociedad y protección de los derechos y de la dignidad de los seres humanos, otros seres vivos y el medioambiente.
Trastornos en la conducta alimentaria: un compromiso multisistémico
Authors: Barrionuevo Colombres Nelida
Published: September 2024

Los trastornos en la conducta Alimentaria (TCA) - o que se evidencian a través del comportamiento alimentario - comprenden Anorexia Nerviosa (AN) Bulimia Nerviosa (BN) y Trastornos no especificados (TANE).Los TCA constituyen un gran desafío para los profesionales de la salud no solo por la gran diversidad y diferente magnitud de los síntomas y signos con los que se manifiestan, si no también por los contextos en que se presentan; en como y porque se manifiestan, las particularidades de los diferentes grupos etáreos, los diferentes géneros- si bien es más frecuente en el sexo femenino-, en todos los grupos socioeconómicos; y todo por las diferentes formas con que el paciente busca “ esconder” “ disfrazar “ su Trastorno alimentario, o no.Toda esta conjunción de aspectos que rodean el tratamiento de los TAC, lleva muchas veces a que el desafío presente situaciones de emergencia -arritmias, hemorragia digestiva, insuficiencia renal, intento de suicidio, lipotimia, convulsiones, depleción electrolítica severa-, o en consultorio externo - amenorrea, intento de suicidio, gastritis, constipación, bradicardia sin causa aparente, lanugo, caída del cabello, desnutrición, otras; que incluso muchas veces lleva a tener que atender primero la urgencia para después abocarse a la problemática de base...
Primer reporte de secuencia genómica completa y análisis filogenético de Bocavirus Humano 1 aislado en Argentina
Authors: Cardozo Tomás Agustina , Ghietto Lucía María , Insfrán Constanza , Wasinger Nicolás Sebasián , Marchesi Ariana Lucía , Adamo María Pilar
Published: September 2024

Antecedentes. El Bocavirus humano (HBoV) es un parvovirus descripto por primera vez en 2005, asociado a cuadros leves y graves de infección respiratoria aguda (IRA), una de las principales causas de morbimortalidad en la población infantil en todo el mundo. Al presente se han identificado 4 genotipos, nombradas HBoV1 a 4, de los cuales el primero es el que se asocia a IRA con predominancia.Objetivo. Obtener el genoma completo de HBoV respiratorio aislado localmente.Métodos. Se diseñaron primers para fragmentos superpuestos del genoma completo de HBoV, empleando las herramientas informáticas ClustalW y NCBI Primer-Blast. Los fragmentos se amplificaron por PCR convencional y se secuenciaron mediante tecnología capilar BigDye Terminator. La edición de las secuencias y análisis filogenético se realizó con el programa MEGA v6.Resultados. Se obtuvo la secuencia genómica completa de HBoV1 cepa 307AR09, aislada de secreción respiratoria de paciente pediátrico con bronquiolitis. La misma fue depositada en la base de datos GenBank con número de acceso KJ634207. El análisis filogenético con secuencias genómicas completas de los 4 genotipos obtenidas en distintas regiones del mundo muestra similitud cercana al 100% con la secuencia original descubierta en Suecia (DQ000495), así como el agrupamiento de los 4 genotipos en 2 clusters de alta homología interna: HBoV1-HBoV3 y HBoV2-HBoV4.Conclusiones. Se aportan datos locales para futuros desarrollos tecnológicos destinados tanto a la investigación como al diseño de métodos diagnósticos para la práctica médica. Por otra parte, los resultados sustentan la propuesta de redistribución taxonómica de los 4 genotipos en 2 especies.
Tobacco use among school enrolled and no enrolled adolescent in Medellin, Colombia. A population survey
Authors: Restrepo Alexandra , Montoya Nilton E
Published: September 2024

Background:Tobacco use among adolescents is a problematic risk behavior with early age of onset and consequences in health outcomes in adulthood. Objectives: Estimate the prevalence of tobacco use among adolescents at school and off school. Methods: A community-base cross sectional study was conducted during 2007 to estimate the prevalence of tobacco consumption in adolescents aged 12-15 (n=1.998), school and off school. A multistage probability sampling was conducted. Results: Life prevalence of tobacco consumption was 26.8% and currently use tobacco was 6%, the age onset was 11 years; non-enrolled in school adolescents had higher smoking rates. Majority of current smokers were able to buy cigarettes. Conclusion: Non-enrolled adolescents have more risk to tobacco use. Public policies should generate strategies to intervene this population. It is important to conduct the Global Youth Tobacco Survey in a national sample of adolescents including of school adolescents and establish an epidemiological surveillance system of risk behaviors based on surveys conducted periodically.Antecedentes:El consumo de tabaco entre los adolescentes es un comportamiento de riesgo problemática para la salud, de inicio cada vez mas temprano y afecta los resultados de salud. Objetivo: Estimar la prevalencia de consumo de tabaco entre los adolescentes escolarizados y no escolarizados. Métodos: Estudio transversal de base poblacional en 2007 para estimar la prevalencia de consumo de tabaco en adolescentes de 12-15 (n = 1.998), escolarizado y no escolarizados. Se uso muestreo probabilístico pilietápico. Resultados: La prevalencia en vida de consumo de tabaco fue del 26,8% y el consumo actual de tabaco fue del 6%, la aparición de edad fue de 11 años; no inscrito en adolescentes escolares tenían mayores tasas de tabaquismo. La mayoría de los fumadores actuales fueron capaces de comprar cigarrillos. Conclusión: los adolescentes no escolarizados tuvieron más riesgo para el consumo de tabaco. Las políticas públicas deben intervenir la población no-escolarizadas. Es importante llevar a cabo la Encuesta Mundial de Tabaquismo en Jóvenes en una muestra nacional que incluya adolescentes incluyendo escolarizados y no escolarizados y establecer un sistema de vigilancia epidemiológica de las conductas de riesgo en base a encuestas realizadas periódicamente.
Síndrome de Vogt-Koyanagi-Harada
Authors: Serna-Ojeda Juan Carlos , Pedroza-Seres Miguel
Published: September 2024

El síndrome de Vogt-Koyanagi-Harada es una enfermedad con hallazgos dermatológicos, neurológicos y auditivos, asociada con una panuveítis granulomatosa bilateral. Presentamos el caso de una mujer de 42 años de edad que inició con manifestaciones oftalmológicas, y en el seguimiento a largo plazo desarrolló los hallazgos dermatológicos clásicos.
Mecanismos moleculares en metaplasia osteocartilaginosa vascular: revisión sistemática
Authors: Rosero Salazar Doris Haydee
Published: September 2024

Introducción: Las metaplasias cartilaginosas y óseas que ocurren tanto en el corazón como en los vasos sanguíneos, son consecuencia de factores de riesgo o enfermedades crónicas que gradualmente afectan negativamente el desempeño de una persona en la sociedad y que corresponden a signos clínicos reversibles en estadíos tempranos o intermedios de las alteraciones. Objetivo: Establecer la manera en que los mecanismos moleculares fundamentan los crecientes cambios metaplásicos vasculares y los posibles aspectos de tratamiento y prevención. Materiales y métodos: Se realizó una revisión sistemática mediante la búsqueda de artículos indexados en las bases de datos PubMed, Scopus y Science Direct entre 1995 a 2015. Los descriptores MeSH utilizados fueron metaplasia and vascular calcification, a los que se asociaron los términos de molecular mechanisms, condrogenic and osteogenic. Resultados y discusión: Múltiples factores influyen en el cambio metaplásico, en especial los pro-inflamatorios asociados a la oxidación vascular y la presencia de radicales libres, cuyo desarrollo es reversible mediante el tratamiento con antioxidantes y las modificaciones en el estilo de vida, así como la prevención secundaria al existir un diagnóstico de enfermedad crónica degenerativa.  Conclusión: La literatura evidencia que los factores que reduzcan el estrés oxidativo tisular y que promuevan el mantenimiento del fenotipo vascular son protectores y/o reductores de las formaciones metaplásicas osteocartilaginosas.
Roles emergentes del Doctor en Ciencias de la Salud: Un abanico de posibilidades en el siglo XXI
Authors: Soria Elio A. , Valentich Mirta A. , Berra Silvina
Published: September 2024

El campo de acción de un Doctor egresado del Doctorado en Ciencias de la Salud se extiende, hoy, más allá de las perspectivas laborales que venían desarrollando. Inicialmente las perspectivas estaban circunscritas al ámbito académico, sea dentro de la Universidad o de organismos gubernamentales promotores de ciencia y tecnología, tales como el Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Otra posición más tradicionalista tomaba la obtención de este título como cierre consagratorio de la vida profesional. Actualmente, en consonancia con tendencias internacionales y nacionales, es posible considerar otros campos de acción de un Doctor en Ciencias de la Salud, con un amplio abanico de posibilidades laborales y un nuevo perfil destinado a cubrirlas, enfrentando las exigencias de este siglo XXI...
Evaluación del Insomnio como Factor de Riesgo para Suicidio
Authors: Escobar-Córdoba Franklin , Quijano-Serrano Margarita , Quijano-Serrano Margarita , Calvo-González José Manuel , Calvo-González José Manuel
Published: September 2024

Resumen Objetivo: realizar una revisión no sistemática de la literatura para describir la relación entre insomnio y suicidio y los hallazgos de dichos estudios.Método: se realizó una búsqueda en las bases de datos PubMed, Medline, SciELO, LILACS, OVID y Cochrane Library combinando los términos MESH: “Suicide AND sleep initiation and maintenance disorders”.Resultados: el insomnio se ha asociado a ideas suicidas, intentos y muertes por suicidio en estudios poblacionales desde hace varios años. El suicidio es una de las principales causas de muerte en el mundo.Discusión: Existen varios factores de riesgo para suicidio; algunos no son modificables, como la edad, el género masculino y etnicidad caucásica. Otros potencialmente modificables como síntomas de depresión, abuso de sustancias y alteraciones del sueño. Entre dichas perturbaciones, el insomnio ha sido el síntoma más comúnmente asociado al suicidio. De hecho se ha considerado que el insomnio es el predictor más potente de intentos de suicidio letales que la existencia misma de un plan específico para cometer suicidio.Conclusiones: Se destaca la importancia para los médicos de detectar y evaluar con detenimiento el insomnio como un signo de alarma y factor de riesgo para suicidio, sin importar, el motivo de consulta de los pacientes.
Hypovitaminosis D in patients with type 2 diabetes
Authors: Ramírez Stieben Luis Agustín , Dobry Raquel , Anca Lilian , González Adrián , López María Isabel , Bayo Salvador , Sánchez Ariel , Brance María Lorena
Published: September 2024

Introduction. Several studies reported than vitamin D deficiency increases the risk of macrovascular and microvascular disease in patients with type 2 diabetes (T2DM). We investigated the plasma levels of 25OHD in adult patients T2DM, risk factors for 25OHD deficiency and the relationship between 25OHD, glycemic control and chronic complications of T2DM.
Methods. A cross-sectional study was carried out, in which 25OHD levels were evaluated in adult patients (over 18 years) with T2DM. Correlation analyses were performed to evaluate the interdependence of the 25OHD with other continuous variables. A receiver operating characteristic analysis was also performed to identify cutoff values for diagnosing vitamin D deficiency. Logistic regression was performed to identify the independent association between vitamin D deficiency and the variables associated with lower 25OHD.
Results. 208 patients were analyzed. The mean age of the patients was 62 years.  The 25OHD level was 19 ng/ml (IQR 13.28-24.43), 59.78% had vitamin D deficiency, and 10.33% had severe deficiency. Glycemia, HbA1c, and BMI were negatively correlated with 25OHD. Cutoff point for vitamin D deficiency was 33.39 kg/m2 for body mass index (BMI), 123 mg/dl for glycemia, and 6.65% for HbA1c. In multivariate logistic regression, BMI>33.39 kg/m2, glycemia >123.5 mg/dl, and albuminuria presented higher odds of vitamin D deficiency.
Major conclusion. Vitamin D deficiency was highly prevalent among patients with T2DM. Low levels were related to higher fasting plasma glucose, higher BMI, and diabetic nephropathy.
Zebrafish as a Model System for Brugada Syndrome
Authors: Verkerk Leonie , Verkerk Arie O. , Wilders Ronald
Published: September 2024

Brugada syndrome (BrS) is an inheritable cardiac arrhythmogenic disease, associated with an increased risk of sudden cardiac death. It is most common in males around the age of 40 and the prevalence is higher in Asia than in Europe and the United States. The pathophysiology underlying BrS is not completely understood, but several hypotheses have been proposed. So far, the best effective treatment is the implantation of an implantable cardioverter-defibrillator (ICD), but device-related complications are not uncommon. Therefore, there is an urgent need to improve diagnosis and risk stratification and to find new treatment options. To this end, research should further elucidate the genetic basis and pathophysiological mechanisms of BrS. Several experimental models are being used to gain insight into these aspects. The zebrafish (Danio rerio) is a widely used animal model for the study of cardiac arrhythmias, as its cardiac electrophysiology shows interesting similarities to humans. However, zebrafish have only been used in a limited number of studies on BrS, and the potential role of zebrafish in studying the mechanisms of BrS has not been reviewed. Therefore, the present review aims to evaluate zebrafish as an animal model for BrS. We conclude that zebrafish can be considered as a valuable experimental model for BrS research, not only for gene editing technologies, but also for screening potential BrS drugs.
IL-4-Induced Gene 1: A Potential Player in Myocardial Infarction
Authors: Shen Rui , Ding Yan , Dong Qian , Wang Yue , Yu Jian , Pan Chengliang , Cai Yifan , Li Zhiyang , Zhang Jiangmei , Yu Kunwu , Zeng Qiutang
Published: September 2024

Myocardial infarction (MI), a severe outcome of cardiovascular disease, poses a serious threat to human health. Uncontrolled inflammation and excessive cardiomyocyte death, following an infarction event, significantly contribute to both the mortality rate and complications associated with MI. The protein IL-4-induced gene 1 (IL4I1 or FIG1) serves as a natural inhibitor of innate and adaptive immunity, playing a crucial role in CD4+ T cell differentiation, macrophage polarization, and ferroptosis inhibition. Previous studies have linked IL4I1 to acute MI. This review summarizes evidence from both basic and clinical research, highlighting IL4I1 as a critical immunoregulatory enzyme that not only regulates inflammatory responses, but also potentially mitigates MI-induced damage.
Intramural dissection of the esophagus is a rare complication of eosinophilic esophagitis in children
Authors: Kornienko E. A. , Babaeva U. M. , Pavelets N. K.
Published: September 2024

Eosinophilic esophagitis (EoE) is characterized by endoscopic signs and detection of more than 15 eosinophils per high-power field of view in biopsy specimens of the esophageal mucosa. Due to deep chronic eosinophilic inflammation, it can cause complications: esophageal stenosis, rarely perforation. Intramural esophageal dissection (IED) is a previously undescribed complication of EoE in children. We present a case of IED in a 15-year-old boy, which clinically manifested itself as sudden epigastric pain radiating to the back and nausea against the background of acute respiratory viral infection. According to endoscopy, CT and X-ray contrast study, a double-barreled esophagus with two cavities was detected - the esophagus itself and a blind "pocket", histologically in which granulation tissue and active inflammation with a large number of neutrophils were found. The initial histological examination did not reveal significant eosinophilic infiltration in the esophagus. The boy received a course of esomeprazole and was re-examined 6 months later. The radiographic picture was the same, and endoscopic examination revealed characteristic signs of EoE: longitudinal grooves and erosions, transverse rings, and narrowing of the esophageal lumen. In the middle third, the picture of a double-barreled esophagus was still preserved, but without signs of acute detachment, but with a dense septum between the two cavities of the esophagus. Histologically, the infiltrate contained more than 50 eosinophils in the field of view. The diagnosis was eosinophilic esophagitis complicated by RTI. A strict hypoallergenic diet was prescribed, excluding obligate allergens, budesonide 1 mg 2 times a day in the form of a gel. Endoscopic dissection of the esophageal septum was performed, its patency was restored. After 2 months, the boy was examined again while continuing drug therapy and diet. He had no complaints, radiologically the patency of the esophagus was not impaired. Endoscopically, the esophagus was freely passable, there was only a small fold at the site of the operation, longitudinal grooves and small erosions in the lower third remained. Histologically, the number of eosinophils decreased significantly. Therapy was continued. This clinical case demonstrates the possibility of developing RDI as a complication of EoE. The course of EoE can be asymptomatic, and RDI is the first manifestation of the disease. The endoscopic picture of a double-barreled esophagus is a consequence of dissection. The combination of a hypoallergenic diet, topical steroids and endoscopic septectomy is effective in the treatment of EoE with RDI.
Siderosis of the esophagus
Authors: Minibaeva G. F. , Yutsevich O. K. , Yagubova E. A. , Volchenko N. N. , Pirogov S. S. , Kaprin A. D.
Published: September 2024

This publication describes a rare clinical case of esophageal siderosis. The patient was found to have flat irregularly shaped superficial scars with areas of hyperpigmentation of the esophageal mucosa in a dark color. It is known from the anamnesis that she has long suffered from iron deficiency anemia and takes iron preparations. A conclusion was made about the defeat of the esophageal mucosa by iron sulfate preparations - esophageal siderosis. The endoscopic conclusion was confirmed by a pathomorphological study - a few cells with brown pigment in the cytoplasm were found in the subepithelial connective tissue - a picture of siderosis
Possibilities of endoscopic adjuvant use of Mitomycin-S in the treatment of benign airway stenoses
Authors: Kozlov M. V. , Filin A. A. , Raevskaya A. N. , Duvansky V. A.
Published: September 2024

Mitomycin-c is an effective and safe drug in the treatment of benign stenosis of the respiratory tract, to a greater extent increasing the duration of the relapse-free period, the interval between endoscopic manipulations. Due to the lack of clear ideas about the optimal method of administration of the drug, the timing, duration of the application / injection, it is necessary to continue further research.
Indicators, Causes and Strategies of Curbing Burnouts among Lecturers of Some Universities in Cameroon
Authors: Wiysahnyuy Lilian F.
Published: September 2024

In most university settings, lecturers have diverse activities which require an enabling environment for optimum and sustainable performance. The absence of this working climate could lead to an emotional outburst known as burnout, a critical health concern that manifests in different ways. Burnout as a psychological impediment is most often overlooked when discussing the range of factors that usually affect the quality of lecturers' professional output. This is because most academics hardly notice they are emotionally unhealthy until this burnout starts manifesting in other aspects of their lives like physical health, social interactions, work and family. It is on this premise that this paper focuses on the indicators, causes of and strategies that can be put in place to curb burnout among university lecturers. The research design used in this study was a cross-sectional survey where an online questionnaire was used to collect both quantitative and qualitative data from 89 lecturers (47.1% Males, 52.9 Females), age range 30-65 years, of the Universities of Bamenda, Buea and Dschang. Quantitative data obtained from the questionnaire was coded and entered into the Statistical Package for Social Sciences (SPSS) version 26.0 while qualitative data was analysed using thematic analysis. The findings revealed that some of the indicators of burnout often exhibited by lecturers are feeling emotionally and physically drained, irritation at minor issues, feeling misunderstood by colleagues and administrators, being frustrated with part of the job and unpleasant level of pressure. The majority of respondents reported that burnout is often caused by constant criticism, overwork, inadequate compensation and poor working social climate. To reduce this emotional/mental challenge, the respondents suggested that there is a need to set up stress management, self -care and work-life balance programmes, and to promote a positive social climate and adequate motivation at the workplace.
Medical Education Online: Worries and Hopes for the Lower and Middle Income Countries (LMICs)
Authors: Olawale Ridwan A
Published: September 2024

This article delves into the nuanced dynamics of online medical education in LMICs, examining the anxieties and aspirations surrounding this transformative medium while spotlighting the critical issue of geographical inequalities. Pathpath toward equitable medical education in LMICs could truly transform healthcare services, allowing them to rise to meet existing challenges and better serve their populations, classes, or workshops.
Evidence-Based Practice and Naturopathic Medicine: What Do We Know?
Authors: Olawale Ridwan A
Published: September 2024

This article delves into the intricate relationship between evidence-based practice and naturopathic medicine, exploring how these methodologies can coexist and enhance patient care.The intersection of evidence-based practice and naturopathic medicine presents an exciting avenue for both practitioners and patients alike. By combining the principles of holistic care with robust scientific research, naturopathic medicine can not only affirm its validity but also promote improved patient outcomes. As the demand for transparent, effective healthcare continues to rise, the future looks promising for the harmonious integration of these two methodologies.
No evidence for unconscious attentional bias in people with clinically significant symptoms of functional gastrointestinal disorders: A study using the emerging electroencephalographic paradigm of fast periodic visual stimulation
Authors: McKerchar Sarah , Le Mire Eliza , Badcock Nicholas A , Jones Michael , Swift Claire , de Wit Bianca , Ejova Anastasia
Published: September 2024

Background. Functional gastrointestinal disorders (FGIDs) present a significant burden on global healthcare systems, yet their underlying mechanisms remain poorly understood. Emerging evidence suggests a role for unconscious psychological processes, particularly attention. This study seeks to detect unconscious attention patterns in people meeting FGID diagnostic criteria using electroencephalographic (EEG) fast periodic visual stimulation (FPVS), a novel passive method offering high temporal resolution. Methods. Alongside 30 healthy controls, 30 female psychology students meeting Rome IV criteria for irritable bowel syndrome or functional dyspepsia completed an FPVS task involving symptom-related (oddball), negative (oddball), and neutral (base) nouns. Key Results. While we detected unconscious discrimination in a control condition (oddball faces among reshuffled pixels), no significant difference in unconscious attention to symptom-related nouns was observed between groups. Conclusions & Inferences. In suggesting no basis for unconscious attentional bias in FGIDs, these findings echo research measuring unconscious attention using event-related potentials, but should be replicated using more highly valenced emotional words.
Topographic analysis for mapping dunes and assessing dune field resilience using multitemporal LiDAR at White Sands, New Mexico
Authors: Young Brennan , Hood Don , Bishop Michael , Ewing Ryan , Bustos David
Published: September 2024

Sand dune morphology is indicative of complex system interactions at a wide range of spatial and temporal scales that govern dune topographic structure. We created an object-oriented topographic framework based on slope attitude, curvature, and contextual analysis to map and characterize sand dune morphology at White Sands National Park, New Mexico, USA that limits empiricism and reliance on a priori knowledge of dune field structure and dynamics. We used eight LiDAR-derived digital elevation models with our framework to segment sand dunes and characterize dune morphology from 2007 to 2020 and evaluated dune field behavior and resilience. The segmentation is 92% accurate relative to manual mapping. From the segmentation, we calculated dune statistics, including height, width, length, area, volume, area-surface area ratio, circularity, migration rate, and aggradation rate. We found these statistics compared well with prior research. We identified a trend toward fewer dunes with greater area and volume from 2007 to 2020, which may be related to typical dune field maturation or short-term (seasonal to decadal) fluctuations related to weather and dune processes. Changes in dune migration rate and sand flux depended on the strength and directionality of seasonal southwesterly winds and likely periods of intense precipitation or drought. Trends identified in this study can be considered a baseline from which longterm trends identified through on-going monitoring can be evaluated. This research highlights current dependence on incomplete models for mapping and characterizing dunes and landscape resilience, and the need to quantitatively formalize numerous geomorphological concepts.
Salud mental positiva y burnout en profesionales de la salud
Authors: Peña María Lucía Morillo , Martín Daniela Moros , Sus Andrea Morelli , Ramírez Edgar , Palencia-Sánchez Francisco
Published: September 2024

Introducción:El burnout o síndrome de desgaste ocupacional es una de las principales condiciones que afectan la salud mental de la mayoría de los estudiantes de medicina durante su exposición al ambiente laboral como trabajadores del área de la salud. Así mismo se ha visto que algunas de las principales causas que contribuyen al alto nivel de burnout en los estudiantes de medicina son la carga académica intensa, el desequilibrio entre el trabajo y la vida personal, los horarios poco flexibles, el estrés económico, las dificultades en las relaciones interpersonales y en algunos casos, las dificultades con el alojamiento Métodos: Se aplicó un cuestionario a los estudiantes de décimo semestre y doceavo semestre, en donde se indagó acerca de variables sociodemográficas, hábitos de vida saludable como actividad física y hábitos de sueño, y condiciones laborales. Además, se evaluó el nivel de burnout mediante la escala Copenhagen Burnout Inventory (16) y se hizo la medición de la salud mental positiva utilizando la escala Lukat-Positive Mental Health Scale (14), ambas validadas al español (15)(17). Posteriormente se realizó el análisis de datos por medio del aplicativo SPSS mediante pruebas paramétricas y no paramétricas. Resultados: Se encontró que el 100% de los estudiantes de medicina que participaron presentaron burnout, con un nivel de burnout moderado y alto del 72.4% de los participantes. Además, se evidenció que el burnout se presenta más en las mujeres y en décimo semestre en comparación con doceavo semestre. Así mismo con respecto, a los hábitos de vida saludables, se observó que, a mayor puntaje en los instrumentos de buena higiene del sueño y actividad física, mayor era la salud mental positiva y menor el nivel de burnout. Por último, se observó que existía una relación inversa entre el nivel de burnout y el nivel de salud mental positiva, ya que a mayor salud mental positiva se encontraban menores niveles de burnout.Conclusión: El burnout es un problema real que abarca a la mayoría de los estudiantes de medicina durante su exposición al ambiente laboral, así mismo es importante tener en cuenta que el nivel de este se relaciona con la salud mental positiva. A la vez, la salud mental positiva se relaciona con hábitos de vida saludables tales como la actividad física y la buena higiene del sueño. Por lo que estos hallazgos son de suma importancia para realizar intervenciones en mejorar la salud mental de los trabajadores y darles herramientas para combatir el burnout.
Women’s Entrepreneurial Intentions: A Case From Madhesh Based On Skill
Authors: Mishra Shila , Adhikari Shukra Raj , Karki Soni
Published: September 2024

This study investigates the impact of financial skills on women's entrepreneurial intentions in Madhesh Province. Specifically, it examines how cognitive skills, numerical ability, financial literacy, behavioral traits, risk tolerance, and entrepreneurial self-efficacy influence these intentions. A quantitative research design was employed using a survey with a sample of 385 female respondents, including students, job holders, and entrepreneurs. Data were collected through structured questionnaires distributed via mail and social media. The analysis utilized descriptive statistics, correlation, and multiple regression to assess the relationships between financial skills and entrepreneurial intentions. The analysis reveals that financial literacy and behavioral traits are significant predictors of women's entrepreneurial intentions in Madhesh Province. Conversely, cognitive skills, numerical ability, risk tolerance, and entrepreneurial self-efficacy do not show a statistically significant impact. The study confirms the validity of the regression model through collinearity statistics, ensuring robust results. The findings underscore the importance of financial literacy and behavioral traits in shaping women's entrepreneurial intentions. To promote female entrepreneurship, it is recommended to focus on enhancing financial education and developing key behavioral traits. The study contributes to the literature by highlighting region-specific factors affecting women’s entrepreneurial aspirations and suggests tailored interventions for fostering female-led ventures in Madhesh Province.
Breaking the Chains: Unraveling the Intricate Interplay Between Labor Export and Food Import Dynamics in Nepal
Authors: Khatri Bishnu Bahadur , Karki Parbata Devi
Published: September 2024

Labor exports and food imports are two current Nepalese phenomena that are pertinent and have academic value in discussions. Although Nepal is well known for being an agricultural nation, recent years have seen a rise in labor shortages, underutilization of agricultural land, and food shortages. In this consideration, the aim of this paper is to examine the scenario of labor migration in relation to the food import dynamics in Nepal. Secondary data served as the basis for the examination. To explain the quantitative and qualitative data, a mixed method has been employed for the study. There is a direct correlation between the increasing proportion of labor exported from Nepal and the parallel decline in agricultural production and growing Nepal’s food import. The state’s economy always suffers when agricultural products are imported from other nations. In Nepal, the establishment of an independent economy is imperative. In order to create employment opportunities and optimize resource utilization, labor management is essential. Cereal and food imports indicate a potential economic crisis by indicating the outflow of national currency. Proper land use, commercialization, market access, technology transfer, and agricultural policies could all contribute to the country’s sustainable economic growth. It is urgent to break through the vicious circle of importing foods and exporting labour to revive the national economy of Nepal.
Text and Intertextuality in Modern Arabic Poetry of Yoruba Scholars
Authors: Sarumi Kahar Wahab
Published: September 2024

Objectives: This paper examines Arabic poetic texts produced by modern Yoruba scholars, to study how they inter-textualize with poetic texts of classical and early modern poets in Arabic. It does a critical reading of select poems from the corpus of Isa Abu-Bakre (b.1953), and Afis Ayinde Oladosu (b.1967). Whereas the former follows the traditional system in the composition of his poems, the latter writes his collections in free verse. Methods: The paper adopts a method of historicizing the annals of intertextuality, before proceeding to exposit, closely read, and analyze intertextuality cues in the poetry of Yoruba scholars. It hinges its discussions on the works of Julia Kristeva, Roland Barthes, James Porter, Lev Vygotsky, Graham Allen, Ahmad Az-Zoubi, and Muhahammad Miftah among others. Conclusions: The study shows that Arabic poetical compositions of modern Yoruba scholars often intersect, not only with poetical texts of classical and early modern poets in Arabic, but also, they inter-textualize with texts from the primary sources of Arabic literary tradition- the Glorious Qur'an and Hadith.
Treatment by smelling in different environments
Authors: Jana Prasenjit
Published: September 2024

As the environment is already filled with many such different smells, we can treat a person by changing his or her environment or it is better to treat a person by changing his position or to take a person for a tour. Atmospheric changes can cause the inner part of our brain to be in a good position. Various types of smells can cause us to think differently in different conditions of different environments. Smelling something can be harmful to us in a position and also can't be harmful to others. So by giving some compounds or elements to smell we can treat someone and this type of treatment can be very useful to treat a brain disease because the smell of a thing can reach our brain as first before the movement of liquid. Different types of smell can give us different types of feelings in our brain and for different types of feelings we can think differently in different regions of circumstances with different smells. So by changing the environment with chemical compounds we can fill the environment with different smells that different types of environment can make us feel sometimes better or bad.
PENGEMBANGAN GAME INTERAKTIF VISUAL NOVEL REN’PY BERBASIS PEMBANGUNAN AKHLAK UNTUK ANAK - ANAK
Authors: Pharisy Alif , Maulani Jauhari , Rais Wathani Muhammad
Published: September 2024

Penelitian ini bertujuan untuk mengembangkan game interaktif berbasis visual novel menggunakan platform Ren'Py yang mengajarkan nilai-nilai akhlak kepada anak-anak sekolah dasar. Masalah utama yang dihadapi meliputi perancangan visual novel yang efektif, pengujian dampak game terhadap pemahaman dan penerapan nilai-nilai akhlak, serta analisis responden menggunakan metode Prototyping. Kesimpulan pada pembuatan game visual novel ini berfokus dalam menggambungkan moral, menggunakan Ren'Py dengan bahasa pemrograman Python. Hasilnya menunjukkan bahwa game ini berhasil meningkatkan motivasi dan pemahaman anak-anak terhadap nilai-nilai Islami, dan diharapkan anak-anak dapat menikmati serta menyukai game ini. Interaksi yang ditawarkan oleh game ini dirancang agar menarik perhatian mereka, memancing rasa penasaran, serta memberikan pengalaman belajar yang menyenangkan.untuk penelitian selanjutnya termasuk pengembangan fitur interaktif tambahan, penambahan mode Bahasa Inggris, serta pengembangan game untuk platform macOS guna memperluas jangkauan pengguna.
APLIKASI MANAJEMEN KENAIKAN GAJI BERKALA, CUTI DAN PENSIUN PEGAWAI PADA BADAN PENDAPATAN DAERAH PROVINSI KALIMANTAN SELATAN BERBASIS WEB
Authors: Weny Niken Anjar , Muin Agus Alim , Setiadi Budi
Published: September 2024

Badan Pendapatan Daerah Provinsi Kalimantan Selatan merupakan lembaga teknis yang bertanggung jawab dalam pengelolaan pendapatan daerah, termasuk pemungutan pajak, retribusi, dan pengelolaan dana transfer daerah. Dengan struktur organisasi yang terdiri dari satu bagian, dua sub bagian, dan tiga bidang, badan ini memainkan peran krusial dalam mendukung keuangan daerah. Namun, observasi menunjukkan bahwa manajemen data kepegawaian, seperti kenaikan gaji berkala, cuti, dan pensiun, masih dilakukan secara manual, yang berdampak pada efektivitas dan efisiensi kerja. Dalam upaya meningkatkan efisiensi kerja, dikembangkan sebuah sistem berbasis website yang mengotomatisasi pengelolaan data kepegawaian. Aplikasi manajemen kenaikan gaji berkala, cuti dan pensiun pegawai ini berbasis multiuser, dan menggunakan framework laravel. Pengujian aplikasi menggunakan metode blackbox testing. Sistem ini dirancang untuk menggantikan proses manual yang rentan terhadap kesalahan dan kehilangan data akibat masalah teknis. Aplikasi "Manajemen Kenaikan Gaji Berkala, Cuti, dan Pensiun Pegawai pada Badan Pendapatan Daerah Provinsi Kalimantan Selatan" diharapkan mampu mempermudah proses manajemen kepegawaian, serta meningkatkan efektivitas dan efisiensi operasional.
APLIKASI HOTEL BERBASIS WEB PADA DISBUDPORAPAR (DINAS KEBUDAYAAN, KEPEMUDAAN, OLAHRAGA dan PARIWISATA) KOTA BANJARMASIN
Authors: Dicky Putra Mahendra Muhammad , Maulani Jauhari , Wathani Muhammad Rais
Published: September 2024

Dinas Kebudayaan, Kepemudaan, Olahraga dan Pariwisata Kota Banjarmasin merupakan salah satu Perangkat Daerah yang menyelenggarakan urusan pemerintahan dalam bidang kebudayaan, Kepemudaan, Olahraga dan Pariwisata. Namun, proses pengelolaan dan pencatatan data hotel pada bidang pariwisata saat ini masih dilakukan secara manual menggunakan perangkat lunak seperti Microsoft Excel, Microsoft Word, yang dapat menyebabkan inefiensi dan risiko kehilangan data. Penelitian ini bertujuan untuk mengembangkan Aplikasi Hotel Berbasis Web yang dapat meningkatkan efisiensi dan efektivitas dalam pengelolaan data dan pembuatan laporan. Metode pengembangan perangkat lunak yang digunakan adalah model waterfall, yang meliputi tahap analisis kebutuhan, desain sistem, implementasi, integrasi dan pengujian, serta operasi dan pemeliharaan. Pengumpulan data dilakukan melalui wawancara, observasi, dokumentasi.Hasil dari penelitian ini menunjukkan bahwa dengan adanya aplikasi ini dapat mempermudah pegawai dalam mendata hotel yang ada di Banjarmasin dan mempercepat pegawai dalam pembuatan laporan untuk kepala dinas sehingga mempermudah kinerja pegawai bidang pariwisata. Kata Kunci:  Aplikasi Hotel, Website, Waterfall, DISBUDPORAPAR.