bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Aplikasi Presensi Pegawai Bagian Produksi Menggunakan Qr Code Berbasis Web Dan Android
Authors: Lahagu Pasrah , Tuti Siregar Elida
Published: June 2023

PT. Super Andalas menggunakan pencatatan absensi dengan menggunakan mesin absensi Check Clock dalam mencatat kehadiran karyawan, sehingga sering terjadinya antrian saat melakukan pengambilan absensi dan rentan terjadi kecurangan. Solusi yang ditawarkan pada permasalahan yang sudah dijelaskan diatas adalah dengan membangun sebuah aplikasi pencatatan absensi pegawai digital yang disajikan dalam bentuk aplikasi berbasis android dan web yang dilengkapi dengann fitur geofence dengan menggunakan metode QR Code, sehingga pegawai tidak dapat melakukan absensi jika berada diluar area yang telah ditentukan, yang dapat melakukan pendeteksian keberadaan perangkat yang pergunakan saat akan melakukan proses absensi. Menurut penulis fungsi QR code adalah untuk menyimpan semua informasi data yang berkaitan dengan absensi, lokasi tempat kerja, data pegawai dalam perusahaan Untuk mengatasi terjadinya antrian dan kecurangan dalam proses pengambilan data maka dikembangkan konsep pencatatan absensi secara digital dengan melakukan penerapan QR code dan pemanfaatan fungsi dari geofencing untuk membatasi area absensi, berdasarkan hal tersebut maka dihasilkan sebuah aplikasi berbasis web dan android yang dapat melakukan pencatatan data absensi dengan penerapan pembatasan area dan pembacaan QR code. Sistem yang dihasilkan memiliki fitur geofencing dan scanning Qr code.
Restrukturisasi Tata Letak Menggunakan Metode Tradisional Berbasis 5S (Seiri, Seiton, Seiso, Seiketsu dan Shitsuke) di PT. CAS
Authors: Yudha Ade , Marwan
Published: June 2023

Untuk mencapai proses produksi yang lebih efisien, tata letak fasilitas harus direstrukturisasi. PT. CAS merupakan perusahaan yang bergerak di bidang industri packaging carton. Dalam proses produksi carton box, terlihat sering terjadi downtime yang di akibatkan oleh penumpukan bahan sisa dan peralatan produksi yang berserakan. Sebuah metode yang sering digunakan untuk mengatasi downtime yang dialami dengan metode tradisional berbasis 5S (Seiri, Seiton, Seiso, Seiketsu, dan Shitsuke). Analisis material yang dilakukan dengan metode 5S adalah analisis biaya material handling. Analisis metode 5S diperoleh tata letak yang rapi, yaitu Seiri memisahkan peralatan produksi yang digunakan dengan yang tidak digunakan, Seiton peralatan produksi disusun rapi di gudang peralatan produksi, Seiso menjaga kebersihan lingkungan, mesin dan peralatan produksi, Seiketsu diterapkan penjadwalan piket kebersihan kepada setiap karyawan produksi, Shitsuke melakukan sosialisai terhadap semua karyawan agar selalu membiasakan diri untuk berdisiplin. Dari hasil perbandingan didapati selisih keseluruhan yaitu Rp.365.423/harinya dengan persentase 59% dan 9.500.998/bulannya dengan persentase 59% yang berarti hasil restrukturisasi tata letak lebih efektif.
Optimalisasi Proses Produksi Cup Nut (Komponen Mesin Kelapa Sawit) Dengan Linear Programing Melalui Metode Simpleks Pada PT XYZ
Authors: 123 Kurniawan , Marwan
Published: June 2023

Persaingan wirausaha semakin ketat, terutama karena jumlah perusahaan meningkat. Situasi ini telah menyebabkan semakin banyak perusahaan berlomba-lomba untuk posisi teratas dalam industri. Oleh karena itu, semua organisasi harus berkembang dan meningkatkan kinerjanya untuk mencapai efektivitas dan efisiensi. Setiap orang (entrepreneur) harus bisa melihat peluang yang ada di bidang ini dan mencari peluang yang ada untuk bersaing dalam bisnis. CV Adi Jaya Teknik memperoleh bahan baku dari beberapa supplier. Pemesanan bahan baku per bulannya mencapai 15.000 buah tergantung pada pemesanan produk dari para costumer. Perusahaan CV Adi Jaya Teknik tidak hanya memperoduksi cup nut saja namun masi banyak produk yang dihasilkan.Berdasarkan data CV Adi Jaya Teknik, terlihat bahwa keuntungan yang direalisasikan atau marjin Keuntungan per unit produk Rp. 150.000 untuk kulit kacang kecil dan Rp. 250.000 untuk mur cangkang besar. Keuntungan atau Profit Argument Pada Proses Pembuatan Cup Nut Menggunakan Linear Programming Menggunakan Metode Simplex adalah sebesar Rp. 562.500 per hari atau Rp. 14.062.500 per bulan.
Effect of Molybdenum Trioxide in the Behavior of Poly(vinyl alcohol) Nanocomposites Systems Focusing New Systems for Protection against COVID-19
Authors: Tavares Maria Inês Bruno , Filho José Carlos Dutra , Nascimento Tais , Iulianelli Gisele Cristina Valle , Merat Pedro Paulo
Published: June 2023

The purpose of this work was to study the molecular dynamics, morphology, mechanical and thermal performance of nanomaterials formed by poly(vinyl alcohol) and molybdenum trioxide (PVA/MoO3) obtained through solution casting method, focusing new materials with therapeutic applications since the molybdenum trioxide exhibit an excellent antibacterial activity and could be a pathway to prevent viruses. The obtaining materials were characterized by conventional techniques as X-ray diffraction, thermogravimetric and dynamical-mechanical analysis. The unconventional low-field NMR relaxometry was used to evaluate the molecular dynamic and morphology of these systems. The results obtained showed that the MoO3 addition into PVA matrix promote an increase on the thermal stability at higher temperatures and a progressive increase on the rigidity of the PVA systems. Also changes in the molecular mobility of nanomaterials determined through the proton spin-lattice relaxation time showed that low proportion of molybdenum trioxide increased the intercalation of the poly(vinyl alcohol) chains between oxide lamellae while higher quantity of molybdenum trioxide caused an inverse effect on the oxide lamellae delamination. From those results the nanomaterials presented a mixed structural organization as intercalated and exfoliated morphologies. According to these first results, the nanocomposites obtained promise to be antimicrobial and antiviral agent to prevent COVID-19 and similar viruses.
Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology
Authors: Benson Al B. , Venook Alan P. , Al-Hawary Mahmoud M. , Azad Nilofer , Chen Yi-Jen , Ciombor Kristen K. , Cohen Stacey , Cooper Harry S. , Deming Dustin , Garrido-Laguna Ignacio , Grem Jean L. , Hecht J. Randolph , Hoffe Sarah , Hubbard Joleen , Hunt Steven , Hussan Hisham , Jeck William , Johung Kimberly L. , Joseph Nora , Kirilcuk Natalie , Krishnamurthi Smitha , Maratt Jennifer , Messersmith Wells A. , Meyerhardt Jeffrey , Miller Eric D. , Mulcahy Mary F. , Nurkin Steven , Overman Michael J. , Parikh Aparna , Patel Hitendra , Pedersen Katrina , Saltz Leonard , Schneider Charles , Shibata David , Skibber John M. , Sofocleous Constantinos T. , Stotsky-Himelfarb Eden , Tavakkoli Anna , Willett Christopher G. , Williams Grant , Algieri Frankie , Gurski Lisa , Stehman Katie
Published: June 2023

This discussion summarizes the NCCN Clinical Practice Guidelines for managing squamous cell anal carcinoma, which represents the most common histologic form of the disease. A multidisciplinary approach including physicians from gastroenterology, medical oncology, surgical oncology, radiation oncology, and radiology is necessary. Primary treatment of perianal cancer and anal canal cancer are similar and include chemoradiation in most cases. Follow-up clinical evaluations are recommended for all patients with anal carcinoma because additional curative-intent treatment is possible. Biopsy-proven evidence of locally recurrent or persistent disease after primary treatment may require surgical treatment. Systemic therapy is generally recommended for extrapelvic metastatic disease. Recent updates to the NCCN Guidelines for Anal Carcinoma include staging classification updates based on the 9th edition of the AJCC Staging System and updates to the systemic therapy recommendations based on new data that better define optimal treatment of patients with metastatic anal carcinoma.
NCCN Guidelines® Insights: Breast Cancer, Version 4.2023
Authors: Gradishar William J. , Moran Meena S. , Abraham Jame , Abramson Vandana , Aft Rebecca , Agnese Doreen , Allison Kimberly H. , Anderson Bethany , Burstein Harold J. , Chew Helen , Dang Chau , Elias Anthony D. , Giordano Sharon H. , Goetz Matthew P. , Goldstein Lori J. , Hurvitz Sara A. , Jankowitz Rachel C. , Javid Sara H. , Krishnamurthy Jairam , Leitch A. Marilyn , Lyons Janice , Mortimer Joanne , Patel Sameer A. , Pierce Lori J. , Rosenberger Laura H. , Rugo Hope S. , Schneider Bryan , Smith Mary Lou , Soliman Hatem , Stringer-Reasor Erica M. , Telli Melinda L. , Wei Mei , Wisinski Kari B. , Young Jessica S. , Yeung Kay , Dwyer Mary A. , Kumar Rashmi
Published: June 2023

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer address all aspects of management for breast cancer. The treatment landscape of metastatic breast cancer is evolving constantly. The therapeutic strategy takes into consideration tumor biology, biomarkers, and other clinical factors. Due to the growing number of treatment options, if one option fails, there is usually another line of therapy available, providing meaningful improvements in survival. This NCCN Guidelines Insights report focuses on recent updates specific to systemic therapy recommendations for patients with stage IV (M1) disease.
¿La competencia digital docente favorece la inclusión educativa?
Authors: Kerexeta Brazal Itziar , Darretxe Urrutxi Leire
Published: June 2023

Research has shown that both educational inclusion and digital competence are priorities in education today. However, not all studies link these two issues. Therefore, this article, which is part of a broader research, aims to analyse the meaning of educational inclusion and teachers' digital competences in the case of conectandoescuelas.org in order to identify aspects that facilitate better quality in education. We conducted a qualitative study through 6 focus groups meetings in the Basque Country and Latin America with K-12 teachers. The data were transcribed and analysed using the semantic analysis software NVIVO 1.2 Release. It was found that society is becoming increasingly technological and this has an impact on schools. While it is not easy to define what it means to be digitally competent and educationally inclusive, teachers face barriers in implementing ICT in their daily lives. Although they have facilitating applications in the teaching-learning process, more training is still needed to respond to current challenges.
The conclusions indicate that technology and digital competences for teachers can support educational inclusion, although at present they are still theoretical and idealised constructs that require more contextualised training to respond to the great challenge facing schools today.

La investigación ha demostrado que tanto la inclusión educativa como la competencia digital son prioridades en la educación actual. Sin embargo, no todos los estudios relacionan estas dos cuestiones. Por ello este artículo, que se enmarca dentro de una investigación más amplia, pretende analizar el significado de la inclusión educativa y las competencias digitales docentes en el caso conectandoescuelas.org para identificar aspectos que facilitan una mejor calidad en educación. Optamos por un estudio cualitativo a través de 6 sesiones con grupos focales en Euskadi y Latinoamérica con profesorado de escuelas obligatorias. Los datos se transcribieron y analizaron mediante el software de análisis semántico NVIVO 1.2. Release. Se encontró que la sociedad es cada vez más tecnológica y eso repercute en la escuela. Aunque resulta complejo definir lo que significa ser competente digitalmente y la inclusión educativa, el profesorado se enfrenta a barreras para poder implementar las TIC en su día a día. Si bien cuentan con aplicaciones facilitadoras en el proceso de enseñanza-aprendizaje, todavía se necesita más formación para responder a los retos actuales. Las conclusiones indican que la tecnología y las competencias digitales docentes pueden favorecer la inclusión educativa, aunque en el momento actual aún suponen constructos teóricos e idealizados que demandan más formación contextualizada para responder al gran reto al que se enfrenta la escuela actualmente.
The heat equation on time scales
Authors: Cuchta Tom , Ferreira Rui A.C.
Published: June 2023

We present the use of a Fourier transform on time scales to solve a dynamic heat IVP. This is done by inverting a certain exponential function via contour integral. We include some specific examples and directions for further study.
Generalized derivations and generalized exponential monomials on hypergroups
Authors: Fechner �ywilla , Gselmann Eszter , Sz�kelyhidi L�szl�
Published: June 2023

In one of our former papers "Endomorphisms of the measure algebra of commutative hypergroups" we considered exponential monomials on hypergroups and higher order derivations of the corresponding measure algebra. Continuing with this, we are now looking for the connection between the generalized exponential polynomials of a commutative hypergroup and the higher order derivations of the corresponding measure algebra.
On the existence of optimal solutions to the Lagrange problem governed by a nonlinear Goursat-Darboux problem of fractional order
Authors: Majewski Marek
Published: June 2023

In the paper, the Lagrange problem given by a fractional boundary problem with partial derivatives is considered. The main result is the existence of optimal solutions based on the convexity assumption of a certain set. The proof is based on the lower closure theorem and the appropriate implicit measurable function theorem.
Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function
Authors: Dacheux Denis , Martinez Guillaume , Broster Reix Christine E , Beurois Julie , Lores Patrick , Tounkara Magamba , Dupuy Jean-William , Robinson Derrick Roy , Loeuillet Corinne , Lambert Emeline , Wehbe Zeina , Escoffier Jessica , Amiri-Yekta Amir , Daneshipour Abbas , Hosseini Seyedeh-Hanieh , Zouari Raoudha , Mustapha Selima Fourati Ben , Halouani Lazhar , Jiang Xiaohui , Shen Ying , Liu Chunyu , Thierry-Mieg Nicolas , Septier Amandine , Bidart Marie , Satre Véronique , Cazin Caroline , Kherraf Zine Eddine , Arnoult Christophe , Ray Pierre F , Toure Aminata , Bonhivers Mélanie , Coutton Charles
Published: June 2023

Male infertility is common and complex, presenting a wide range of heterogeneous phenotypes. Although about 50% of cases are estimated to have a genetic component, the underlying cause often remains undetermined. Here, from whole-exome sequencing on samples from 168 infertile men with asthenoteratozoospermia due to severe sperm flagellum, we identified homozygous ZMYND12 variants in four unrelated patients. In sperm cells from these individuals, immunofluorescence revealed altered localization of DNAH1, DNALI1, WDR66, and TTC29. Axonemal localization of ZMYND12 ortholog TbTAX-1 was confirmed using the Trypanosoma brucei model. RNAi knock-down of TbTAX-1 dramatically affected flagellar motility, with a phenotype similar to the sperm from men bearing homozygous ZMYND12 variants. Co-immunoprecipitation and ultrastructure expansion microscopy in T. brucei revealed TbTAX-1 to form a complex with TTC29. Comparative proteomics with samples from Trypanosoma and Ttc29 KO mice identified a third member of this complex: DNAH1. The data presented revealed that ZMYND12 is part of the same axonemal complex as TTC29 and DNAH1, which is critical for flagellum function and assembly in humans, and Trypanosoma. ZMYND12 is thus a new asthenoteratozoospermia-associated gene, bi-allelic variants of which cause severe flagellum malformations and primary male infertility.
Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not ‘stress’
Authors: Jimeno Blanca , Verhulst Simon
Published: June 2023

Glucocorticoid (GC) variation has long been thought to reflect variation in organismal ‘stress,’ but associations between GCs and Darwinian fitness components are diverse in magnitude, direction, and highly context-dependent. This paradox reveals our poor understanding of the causes of GC variation, contrasting with the detailed knowledge of the functional consequences of GC variation. Amongst an array of effects in many physiological systems, GCs orchestrate energy availability to anticipate and recover from predictable and unpredictable environmental fluctuations and challenges. Although this is mechanistically well-known, the extent to which GC levels are quantitatively explained by energy metabolism is unresolved. We investigated this association through meta-analysis, selecting studies of endotherms in which (1) an experiment was performed that affected metabolic rate and (2) metabolic rate and GC levels were measured simultaneously. We found that an increase in metabolic rate was associated with an increase in GC levels in 20 out of 21 studies (32 out of 35 effect sizes). More importantly, there was a strong positive correlation between the increases in metabolic rate and GCs (p=0.003). This pattern was similar in birds and mammals, and independent of the nature of the experimental treatment. We conclude that metabolic rate is a major driver of GC variation within individuals. Stressors often affect metabolic rate, leading us to question whether GC levels provide information on ‘stress’ beyond the stressor’s effect on metabolic rate.
An offer the journal couldn’t refuse
Authors: Rosenkrantz Hansen Claus , Boserup Thestrup Jesper , Rindom Riise Rasmus , Iversen Rie Karen Marie , Johnsen Solveig Sandal
Published: June 2023

The article describes a two-year project (running from 2021 to 2022) that worked on getting Danish Open Access journals indexed in the Directory of Open Access Journals (DOAJ). The project was run in partnership by Copenhagen Business School (CBS Library), Royal Danish Library and Aalborg University Library, in close collaboration with DOAJ. All of the journals that participated are hosted on the libraries’ Open Journal Systems (OJS). In this article the authors demonstrate some of the challenges the journals and the project group faced in the inclusion process and in the assistance the project provided, as well as learning outcomes and perspectives.
Marine aquaculture as a source of propagules of invasive fouling species
Authors: Lins Daniel M. , Rocha Rosana M.
Published: June 2023

Non-indigenous species tend to colonize aquaculture installations, especially when they are near international ports. In addition to the local environmental hazard that colonizing non-indigenous species pose, they can also take advantage of local transport opportunities to spread elsewhere. In this study, we examined the risk of the spread of eight invasive fouling species that are found in mussel farms in southern Brazil. We used ensemble niche models based on worldwide occurrences of these species, and environmental variables (ocean temperature and salinity) to predict suitable areas for each species with three algorithms (Maxent, Random Forest, and Support Vector Machine). As a proxy for propagule pressure, we used the tonnage transported by container ships from Santa Catarina (the main mariculture region) that travel to other Brazilian ports. We found that ports in the tropical states of Pernambuco, Ceará, and Bahia received the largest tonnage, although far from Santa Catarina and in a different ecoregion. The ascidians Aplidium accarense and Didemnum perlucidum are known from Bahia, with a high risk of invasion in the other states. The bryozoan Watersipora subtorquata also has a high risk of establishment in Pernambuco, while the ascidian Botrylloides giganteus has a medium risk in Bahia. Paraná, a state in the same ecoregion as Santa Catarina is likely to be invaded by all species. A second state in this region, Rio Grande do Sul, is vulnerable to A. accarense, the barnacle Megabalanus coccopoma, and the mussel Mytilus galloprovincialis. Climate change is changing species latitudinal distributions and most species will gain rather than lose area in near future (by 2050). As an ideal habitat for fouling organisms and invasive species, aquaculture farms can increase propagule pressure and thus the probability that species will expand their distributions, especially if they are close to ports. Therefore, an integrated approach of the risks of both aquaculture and nautical transport equipment present in a region is necessary to better inform decision-making procedures aiming at the expansion or establishment of new aquaculture farms. The risk maps provided will allow authorities and regional stakeholders to prioritize areas of concern for mitigating the present and future spread of fouling species.
Con el futuro presente
Authors: Venegas Inostroza Juan Pablo
Published: June 2023

No presenta resumen
Conversación
Authors: Macchiavello Cornejo Carla
Published: June 2023

No presenta resumen
En busca de un estatuto jurídico aplicable a la administración de los bienes indivisos.
Authors: Isler Soto Erika
Published: June 2023

La legislación común chilena sobre comunidad no contempla una forma de administración general de los bienes indivisos.El presente artículo expone las principales teorías que intentan dar solución a la cuestión planteada, entre las cuales encontramos a la tesis que le otorga primacía al derecho de veto, la teoría del mandato tácito y recíproco, la tesis de la apariencia jurídica, la teoría de la agencia ofic iosa, el criterio de mayo-ría y la tesis según la cual un comunero puede actuar sin el consentimiento de los demás, cuando este sea el único modo de conservar o amparar su derecho.Por último, se hace alusión a la institución de las medidas conservativas.
Spor Yapma Alışkanlığının Özel Gereksinimli Çocukların Kognitif Becerilerine Etkisi
Authors: ALBAYRAK Özge , ELİÖZ Murat
Published: June 2023

Araştırma özel gereksinimli 80 ve normal gelişim gösteren 20 olmak üzere toplam 100 katılımcı ile yapılmıştır. Özel gereksinimli grup özel öğrenme güçlüğü yaşayan 20, fiziksel özel gereksinimli 20, down sendromlu 20, ve işitme özel gereksinimli 20 çocuktan oluştu. Katılımcılara araştırmacı tarafından geliştirilen demografik anket uygulanmış ve Benton Görsel Bellek Testi ve Cattel 2a Zekâ testi uygulanmıştır. Özel gereksinimli bireylerin spor yapma durumuna göre “Benton görsel bellek testi ve Cattel zekâ testi” karşılaştırma sonucunda Cattel ve Benton doğru ve hata sayısında anlamlı fark bulunmuştur (p
Study on Brand Promotion of Pre-emergence Herbicide in Kurukshetra District of State Haryana, India
Authors: Tripathi Rishita , Barker Nitin
Published: June 2023

The Present study was conducted in the year 2022 with a sample of 100 Rice farmers in Block of Pipli district of Kurukshetra. The study reveals that the market share of Syngenta India Ltd. was found to be on the top rank in the district. The market share and key existing competitors of Rifit Plus herbicide was found to be Top Star, Sokusai Plus, Pretigan, Milfast, Butaveer. A total quantity sale (Litre) in the district of all the herbicides was 26,500 litres. The lowest market share was found to be of Butaveer ranking on 6th position among all other competitors.
Utilization of Information and Communication Technologies among Rural Women and Youth in Agriculture in Abia State, Nigeria
Authors: Jennifer Iyere-Freedom, Chioma , Achonam Enwelu, Innocent
Published: June 2023

The study assessed the utilization of information and communication technologies (ICTs) among rural women and youth in agriculture in Abia State, Nigeria. Data were collected using a structured interview schedule by the researcher and other research assistants. Percentage, standard deviation, mean scores, pie-chart, factor analysis, and regression were used for data analysis and result presentation. Using the multistage sampling procedure, a sample size of one hundred and twenty respondents was purposefully selected. The study's findings showed that GSM, radio, and television were the main ICTs that women and youth in the state used to obtain agricultural information from extension and relevant stakeholders. The regression analysis revealed a positive relationship between the number of times extension agents visited and their level of ICT use in agriculture. Findings indicated that a greater percentage (40%) of respondents were high users of ICTs in agriculture. Respondents cited low literacy, a lack of extension conviction, and training as major constraints to their use of ICTs. The implication is that policymakers and relevant stakeholders in agriculture should prioritize the development of training programs and interventions that improve the technology literacy and human capacity building of rural women and youth in the state through the use of existing agricultural extension programs on the effective use of ICTs in obtaining agricultural information for increased productivity, income, standard of living, and agricultural development in the state.
Application of Response Surface Methodology (RSM) to Cucumber Yield under Different Tillage Methods
Authors: Nwachukwu C. P. , Okoro A. C. , Nwanna E. C. , Umobi C. O.
Published: June 2023

Response surface methodology (RSM) was used in the modeling of cucumber (Cucumissativus) yield under different Nitrogen, phosphorus, potassium (NPK) fertilizer application rates and tillage methods at the experimental farm of the Department of Agricultural and Bio-Resources Engineering, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria. From the field experiment conducted, three tillage methods; conventional tillage (CT), manual tillage (MT) and no tillage (NT), were varied with three levels of NPK application; 0.04kg/m2, 0.05kg/m2 and 0.06kg/m2. All the cucumber plants for no tillage wilted and didn’t survive to maturity, while the highest cucumber yield of 3.29kg/m2 was obtained at conventional tillage/0.06kg/m2 NPK application rate. In optimizing the yield using optimal design of response surface methodology, it was observed that increasing NPK application rate beyond the maximum 0.06kg/m2 increased cucumber yield for the area. The optimized values obtained in the area were: the best tillage method; conventional tillage, NPK application rate of 0.064kg/m2 and cucumber yield of 3.376. The study revealed that no tillage at the chosen NPK application rates is not adequate for the study area. It was also evident that conventional tillage with increased NPK is the best management practice for the area, but care must be taken not to add excess NPK that will not be favourable to the crops and the soil of the area.
Patrimônio insurgente em território invisibilizado
Authors: Gallo Éric , El-Jaick  Andrade Inês
Published: June 2023

O artigo discute a luta de uma comunidade pelo reconhecimento dos atributos patrimoniais de uma edificação tombada e inserida em um território periférico e de conflitos urbanos. A Igreja de São Daniel Profeta, localizada no Complexo de Favelas de Manguinhos (Rio de Janeiro, Brasil), é um projeto de Oscar Niemeyer e está tombada a nível estadual desde 1966 e a nível municipal desde 1998. Moradores lutam por sua integridade a fim de manter o culto e as características que a chancelam como patrimônio moderno. O estudo analisa o processo que culminou em seu tombamento, a significação cultural atribuída pela comunidade de fiéis ao bem e o risco de destombamento. Objetiva-se contribuir com experiências territoriais de movimentos de base comunitária, sob a perspectiva do patrimônio cultural, inserido em contexto de vulnerabilidade social.
Primary Care Spending in the US Population
Authors: Decker Sandra L. , Zuvekas Samuel H.
Published: June 2023

This survey study assesses the 2019 spending estimates on checkups, well-child visits, and diagnosis or treatment provided by primary care physicians, nurses, nurse practitioners, and physician's assistants.
Goals of Care Among Parents of Children Receiving Palliative Care
Authors: Feudtner Chris , Beight Leah J. , Boyden Jackelyn Y. , Hill Douglas L. , Hinds Pamela S. , Johnston Emily E. , Friebert Sarah E. , Bogetz Jori F. , Kang Tammy I. , Hall Matt , Nye Russell T. , Wolfe Joanne ,   PPCRN SHARE Project Group, Arevalo-Soriano Tatiana , Bilodeau Madeline , Catrine Kris , Chapman Jennifer , Crew Karen , Das Porag Jeet , Friebert Sarah , Griffis Heather , Hays Ross , Helton Gabby , Jenkins Rachel , Katkoff Hannah , Kostoff Ali , Maglionico Deborah , Martinez Isaac , Mercer Amanda , Morris Ashley , Nelpati Shimel , Porth Rachel , Sherr Nicole E. , Shipman Kelly , Xiao Rui , Walla Namrata
Published: June 2023

Importance

While knowing the goals of care (GOCs) for children receiving pediatric palliative care (PPC) are crucial for guiding the care they receive, how parents prioritize these goals and how their priorities may change over time is not known.

Objective

To determine parental prioritization of GOCs and patterns of change over time for parents of children receiving palliative care.

Design, Setting, and Participants

A Pediatric Palliative Care Research Network’s Shared Data and Research cohort study with data collected at 0, 2, 6, 12, 18, and 24 months in hospital, outpatient, or home settings from April 10, 2017, to February 15, 2022, at 7 PPC programs based at children’s hospitals across the US. Participants included parents of patients, birth to 30 years of age, who received PPC services.

Exposures

Analyses were adjusted for demographic characteristics, number of complex chronic conditions, and time enrolled in PPC.

Main Outcomes

Parents’ importance scores, as measured using a discrete choice experiment, of 5 preselected GOCs: seeking quality of life (QOL), health, comfort, disease modification, or life extension. Importance scores for the 5 GOCs summed to 100.

Results

A total of 680 parents of 603 patients reported on GOCs. Median patient age was 4.4 (IQR, 0.8-13.2) years and 320 patients were male (53.1%). At baseline, parents scored QOL as the most important goal (mean score, 31.5 [SD, 8.4]), followed by health (26.3 [SD, 7.5]), comfort (22.4 [SD, 11.7]), disease modification (10.9 [SD, 9.2]), and life extension (8.9 [SD, 9.9]). Importantly, parents varied substantially in their baseline scores for each goal (IQRs more than 9.4), but across patients in different complex chronic conditions categories, the mean scores varied only slightly (means differ 8.7 or less). For each additional study month since PPC initiation, QOL was scored higher by 0.06 (95% CI, 0.04-0.08) and comfort scored higher by 0.3 (95% CI, 0-0.06), while the importance score for life extension decreased by 0.07 (95% CI, 0.04-0.09) and disease modification by 0.02 (95% CI, 0-0.04); health scores did not significantly differ from PPC initiation.

Conclusions and Relevance

Parents of children receiving PPC placed the highest value on QOL, but with considerable individual-level variation and substantial change over time. These findings emphasize the importance of reassessing GOCs with parents to guide appropriate clinical intervention.
MeCP2 dysfunction prevents proper BMP signaling and neural progenitor expansion in brain organoid
Authors: Hong Hyowon , Yoon Sae‐Bom , Park Jung Eun , Lee Jung In , Kim Hyun Young , Nam Hye Jin , Cho Heeyeong
Published: June 2023

Objectives

Sporadic mutations in MeCP2 are a hallmark of Rett syndrome (RTT). Many RTT brain organoid models have exhibited pathogenic phenotypes such as decreased spine density and small size of soma with altered electrophysiological signals. However, previous models are mainly focused on the phenotypes observed in the late phase and rarely provide clues for the defect of neural progenitors which generate different types of neurons and glial cells.

Methods

We newly established the RTT brain organoid model derived from MeCP2‐truncated iPS cells which were genetically engineered by CRISPR/Cas9 technology. By immunofluorescence imaging, we studied the development of NPC pool and its fate specification into glutamatergic neurons or astrocytes in RTT organoids. By total RNA sequencing, we investigated which signaling pathways were altered during the early brain development in RTT organoids.

Results

Dysfunction of MeCP2 caused the defect of neural rosette formation in the early phase of cortical development. In total transcriptome analysis, BMP pathway‐related genes are highly associated with MeCP2 depletion. Moreover, levels of pSMAD1/5 and BMP target genes are excessively increased, and treatment of BMP inhibitors partially rescues the cell cycle progression of neural progenitors. Subsequently, MeCP2 dysfunction reduced the glutamatergic neurogenesis and induced overproduction of astrocytes. Nevertheless, early inhibition of BMP pathway rescued VGLUT1 expression and suppressed astrocyte maturation.

Interpretation

Our results demonstrate that MeCP2 is required for the expansion of neural progenitor cells by modulating BMP pathway at early stages of development, and this influence persists during neurogenesis and gliogenesis at later stages of brain organoid development.
Combination Therapy With CD147‐Targeted Nanoparticles Carrying Phenformin Decreases Lung Cancer Growth
Authors: Pereira‐Nunes Andreia , Ferreira Helena , Abreu Sara , Guedes Marta , Neves Nuno M. , Baltazar Fátima , Granja Sara
Published: June 2023

Lung cancer is one of the most fatal cancers worldwide. Resistance to conventional therapies remains a hindrance to patient treatment. Therefore, the development of more effective anti‐cancer therapeutic strategies is imperative. Solid tumors exhibit a hyperglycolytic phenotype, leading to enhanced lactate production; and, consequently, its extrusion to the tumor microenvironment. Previous data reveals that inhibition of CD147, the chaperone of lactate transporters (MCTs), decreases lactate export in lung cancer cells and sensitizes them to phenformin, leading to a drastic decrease in cell growth. In this study, the development of anti‐CD147 targeted liposomes (LUVs) carrying phenformin is envisioned, and their efficacy is evaluated to eliminate lung cancer cells. Herein, the therapeutic effect of free phenformin and anti‐CD147 antibody, as well as the efficacy of anti‐CD147 LUVs carrying phenformin on A549, H292, and PC‐9 cell growth, metabolism, and invasion, are evaluated. Data reveals that phenformin decreases 2D and 3D‐cancer cell growth and that the anti‐CD147 antibody reduces cell invasion. Importantly, anti‐CD147 LUVs carrying phenformin are internalized by cancer cells and impaired lung cancer cell growth in vitro and in vivo. Overall, these results provide evidence for the effectiveness of anti‐CD147 LUVs carrying phenformin in compromising lung cancer cell aggressiveness.
Integration of Activation by Hypoxia and Inhibition Resistance of Tumor Cells to Apoptosis for Precise and Augmented Photodynamic Therapy
Authors: Shao Yutong , Chen Miaomiao , Chen Wenlong , Wang Zehui , Sui Mengzhang , Tian Mingyu , Wu Yingnan , Song Jitao , Ji Debin , Song Fengling
Published: June 2023

Photodynamic therapy (PDT) uses photosensitizers to convert oxygen (O2) to reactive oxygen species (ROS) under irradiation to induce DNA damage and kill cancer cells. However, the effect of PDT is usually alleviated by apoptosis resistance mechanism of tumor living cells. MTH1 enzyme is known to be such an apoptosis‐resistance enzyme which is over expressed as a scavenger to repair the damaged DNA. In this work, a hypoxia‐activated nanosystem FTPA, which can be degraded to release the encapsulated PDT photosensitizer 4‐DCF‐MPYM and an inhibitor TH588 is proposed. The inhibitor TH588 can inhibit the DNA repair process by reducing the activity of MTH1 enzyme, and achieve the purpose of amplifying the therapeutic effect of PDT. This work demonstrates that a precise and augmented tumor PDT is achieved by integration of hypoxia‐activation and inhibition resistance of tumor cells to apoptosis.
Large Anomalous Nernst Effects at Room Temperature in Fe3Pt Thin Films
Authors: Li Minghang , Pi Hanqi , Zhao Yunchi , Lin Ting , Zhang Qinghua , Hu Xinzhe , Xiong Changmin , Qiu Zhiyong , Wang Lichen , Zhang Ying , Cai Jianwang , Liu Wuming , Sun Jirong , Hu Fengxia , Gu Lin , Weng Hongming , Wu Quansheng , Wang Shouguo , Chen Yunzhong , Shen Baogen
Published: June 2023

Heat current in ferromagnets can generate a transverse electric voltage perpendicular to magnetization, known as anomalous Nernst effect (ANE). ANE originates intrinsically from the combination of large Berry curvature and density of states near the Fermi energy. It shows technical advantages over the conventional longitudinal Seebeck effect in converting waste heat to electricity due to its unique transverse geometry. However, materials showing giant ANE remain to be explored. Herein,  a large ANE thermopower of Syx ≈ 2 µV K−1 at room temperature in ferromagnetic Fe3Pt epitaxial films is reported, which also show a giant transverse thermoelectric conductivity of αyx ≈ 4 A K−1 m−1 and a remarkable coercive field of 1300 Oe. The theoretical analysis reveals that the strong spin‐orbit interaction in addition to the hybridization between Pt 5d and Fe 3d electrons leads to a series of distinct energy gaps and large Berry curvature in the Brillouin zone, which is the key for the large ANE. These results highlight the important roles of both Berry curvature and spin‐orbit coupling in achieving large ANE at zero magnetic field, providing pathways to explore materials with giant transverse thermoelectric effect without an external magnetic field.
Direct‐Current Electrical Detection of Surface‐Acoustic‐Wave‐Driven Ferromagnetic Resonance
Authors: Chen Chong , Han Lei , Liu Peisen , Zhang Yichi , Liang Shixuan , Zhou Yongjian , Zhu Wenxuan , Fu Sulei , Pan Feng , Song Cheng
Published: June 2023

Surface acoustic waves (SAW) provide a promising platform to study spin‐phonon coupling, which can be achieved by SAW‐driven ferromagnetic resonance (FMR) for efficient acoustic manipulation of spin. Although the magneto‐elastic effective field model has achieved great success in describing SAW‐driven FMR, the magnitude of the effective field acting on the magnetization induced by SAW still remains hard to access. Here, by integrating ferromagnetic stripes with SAW devices, direct‐current detection for SAW‐driven FMR based on electrical rectification is reported. By analyzing FMR rectified voltage, the effective fields are straightforwardly characterized and extracted, which exhibits the advantages of better integration compatibility and lower cost than traditional methods such as vector‐network analyzer‐based techniques. A large nonreciprocal rectified voltage is obtained, which is attributed to the coexistence of in‐plane and out‐of‐plane effective fields. The effective fields can be modulated by controlling the longitudinal and shear strains within the films to achieve almost 100% nonreciprocity ratio, demonstrating the potential for electrical switches. Besides its fundamental significance, this finding provides a unique opportunity for a designable spin acousto‐electronic device and its convenient signal readout.
On the Mechanism of Solvents Catalyzed Structural Transformation in Metal Halide Perovskites
Authors: Xi Jun , Jiang Junke , Duim Herman , Chen Lijun , You Jiaxue , Portale Giuseppe , Liu Shengzhong (Frank) , Tao Shuxia , Loi Maria Antonietta
Published: June 2023

Metal halide perovskites show the capability of performing structural transformation, allowing the formation of functional heterostructures. Unfortunately, the elusive mechanism governing these transformations limits their technological application. Herein, the mechanism of 2D–3D structural transformation is unraveled as catalyzed by solvents. By combining a spatial‐temporal cation interdiffusivity simulation with experimental findings, it is validated that, protic solvents foster the dissociation degree of formadinium iodide (FAI) via dynamic hydrogen bond, then the stronger hydrogen bond of phenylethylamine (PEA) cation with selected solvents compared to dissociated FA cation facilitates 2D–3D transformation from (PEA)2PbI4 to FAPbI3. It is discovered that, the energy barrier of PEA out‐diffusion and the lateral transition barrier of inorganic slab are diminished. For 2D films the protic solvents catalyze grain centers (GCs) and grain boundaries (GBs) transforme into 3D phases and quasi‐2D phases, respectively. While in the solvent‐free case, GCs transform into 3D–2D heterostructures along the direction perpendicular to the substrate, and most GBs evolve into 3D phases. Finally, memristor devices fabricated using the transformed films uncover that, GBs composed of 3D phases are more prone to ion migration. This work elucidates the fundamental mechanism of structural transformation in metal halide perovskites, allowing their use to fabricate complex heterostructures.
Strategic Management of High‐Lying Triplet Excitons to Realize the Breakthrough in Efficiency of Blue Fluorescence OLEDs Based on AIE Emitter
Authors: Lin Chengwei , Han Pengbo , Qu Fenlan , Xiao Shu , Qiao Xianfeng , Yang Dezhi , Dai Yanfeng , Sun Qian , Qin Anjun , Tang Ben Zhong , Ma Dongge
Published: June 2023

Aggregation‐induced emission (AIE) materials are attractive for the fabrication of high‐efficiency organic light‐emitting diodes (OLEDs) owing to the “hot exciton” process by reverse intersystem crossing (hRISC) and high photoluminescence quantum yields (PLQY). However, the internal conversion (IC) from the high‐lying triplet excitation states (Tn, n≥2) to the lower excited triplet state (Tn‐1) is inevitable, resulting in severe exciton losses. Herein, an effective device structure is designed that reuses the lost triplet excitons caused by IC and realizes the breakthrough in the efficiency of blue fluorescence OLEDs based on AIE molecule as an emitter. The maximum external quantum efficiency reached as high as 14.8% and is kept at 14.4% at the luminance of 1000 cd m−2. In the designed device, a triplet–triplet annihilation (TTA) up‐conversion material 1‐[2,5‐dimethyl‐4‐(1‐pyrenyl)phenyl]pyrene (DMPPP) is introduced into the AIE emitter as a triplet sensitizer to receive the lost triplet excitons, and a thin TTA up‐conversion layer 9‐[4‐(10‐phenyl‐9‐anthryl)phenyl]‐9H‐carbazole (CzPA) is introduced in the middle of the doped layer to form the emissive layer (EML). It is found that the hRISC process of iTPB‐2AC greatly enhances the utilization efficiency of TTA intermediate state ([TT]*) excitons on CzPA to iTPB‐2AC so that the utilization of the lost excitons is maximized. This work establishes physical insights into the AIE emission materials and device fabrication of high‐efficiency blue fluorescence OLEDs.
Thiols as Powerful Atom Transfer Catalyst: Opportunities in Photoredox‐Mediated Reactions
Authors: Bao Xiaobo , Yu Wei , Wang Guoli
Published: June 2023

The employing visible light to drive organic transformations is the most promising choice to meet the needs for green synthesis, in which the reactions promoted by visible light may provide a more efficient and greener method. Currently, the most abundant methods for activation and functionalization of reaction substrates have relied on the direct single‐electron transfer (SET) between the excited photocatalyst and substrates, and these wonderful works were summarized and docoumented in many reviews. As a complement to the above reactions, the photoredox‐mediated atom transfer transformations (photocatalyst‐to‐HAT catalyst‐to‐substrates) to generate radical species are showing an explosively growing trend. In this review, we highlight recent significant developments in this rapidly growing area, mainly focusing on the photoinduced base‐to‐substrates charge transfer reactions.
Cation Disordered Anti‐Perovskite Cathode Materials with Enhanced Lithium Diffusion and Suppressed Phase Transition
Authors: Deng Zhi , Chen Diancheng , Ou Mingyang , Zhang Yuanpeng , Xu Jia , Ni Dixing , Ji Zhaoran , Han Jiantao , Sun Yang , Li Shuai , Ouyang Chuying , Wang Zhaoxiang
Published: June 2023

Recently, a new family of anti‐perovskite Li2TMSO was discovered as promising cathode materials for Li‐ion batteries (LIBs) with superiorities in high specific capacity, low cost, and environmental friendliness. However, the applications of these anti‐perovskite materials meet severe challenges in the cyclability and rate performance. Herein, a cation‐disordered anti‐perovskite type solid solution Li2Fe1−xMnxSO (LFMSO, x = 0, 0.2, 0.5) with excellent electrochemical performance is reported. On the basis of comprehensive structural characterizations, the role of the cation disordering in LFMSO is clarified. In comparison with Li2FeSO (LFSO), the reduced Li‐ion diffusion barrier and the increased Li‐rich octahedral configurations in LFMSO with higher configurational entropy imply the facilitated long‐range Li‐ion diffusion and the suppressed phase transition, which favor the high‐rate capability and cycling stability. In addition, the large lattice distortion and Coulombic interaction between the anions and cations lead to the breathing of the unit cell during charge/discharge. The variation of the unit cell volume decreases to 2.5% upon Li‐ion delithiation. A superstructure is observed in LFMSO for the first time. These findings help to pave the way for the research and development of novel cathode materials for the next generation LIBs.
A Structurally Flexible Halide Solid Electrolyte with High Ionic Conductivity and Air Processability
Authors: Karkera Guruprakash , Soans Mervyn , Akbaş Ayça , Witter Raiker , Euchner Holger , Diemant Thomas , Cambaz Musa Ali , Meng Zhen , Dasari Bosubabu , Chandrappa Shivaraju Guddehalli , Menezes Prashanth W. , Fichtner Maximilian
Published: June 2023

In this work, a structurally revivable, chloride‐ion conducting solid electrolyte (SE), CsSn0.9In0.067Cl3, with a high ionic conductivity of 3.45 × 10−4 S cm−1 at 25 °C is investigated. The impedance spectroscopy, density functional theory, solid‐state 35Cl NMR, and electron paramagnetic resonance studies collectively reveal that the high Cl− ionic mobility originates in the flexibility of the structural building blocks, Sn/InCl6 octahedra. The vacancy‐dominated Cl− ion diffusion encompasses co‐ordinated Sn/In(Cl) site displacements that depend on the exact stoichiometry, and are accompanied by changes in the local magnetic moments. Owing to these promising properties, the suitability of the CsSn0.9In0.067Cl3, as an electrolyte is demonstrated by designing all‐solid‐state batteries, with different anodes and cathodes. The comparative investigation of interphases with Li, Li–In, Mg, and Ca anodes reveals different levels of reactivity and interphase formation. The CsSn0.9In0.067Cl3 demonstrates an excellent humidity tolerance (up to 50% relative humidity) in ambient air, maintaining high structural integrity without compromises in ionic conductivity, which stands in contrast to commercial halide‐based lithium conductors. The discovery of a halide perovskite conductor, with air processability and structure revival ability paves the way for the development of advanced air processable SEs, for next‐generation batteries.
Activating Amorphous Ru Metallenes Through Co Integration for Enhanced Water Electrolysis
Authors: Jose Vishal , Do Viet‐Hung , Prabhu P , Peng Chun‐Kuo , Chen San‐Yuan , Zhou Yingtang , Lin Yan‐Gu , Lee Jong‐Min
Published: June 2023

Designing efficient bifunctional electrocatalysts with excellent activity and robust stability presents a central challenge for the large‐scale commercialization of water electrolysis. Herein, a facile approach is reported for the construct of atomically thin amorphous RuM (MCo, Fe, or Ni) bimetallenes as high‐performance electrocatalysts toward both electrochemical hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). The RuCo bimetallene manifests excellent bifunctional activity characterized by low required overpotentials, superior price activity, robust electrochemical durability as well as a low cell potential water splitting performance, outperforming Pt/C and RuO2 benchmark catalysts. Combined operando X‐ray absorption spectroscopy  investigation and theoretical simulations reveal the synergism taking place between binary constituents, in which Co serves a promotive role along the HER/OER reaction pathway, contributing via optimal binding to *OH for facile water dissociation as well as modulating the Ru electronic structure favorably, hence rendering high activity catalytic centers for both the alkaline HER and OER.