bluuebunny/crossref_metadata_2025 huggingface dataset:
Facile Fabrication of Z-Scheme Bi2WO6/WO3 Composites for Efficient Photodegradation of Bisphenol A with Peroxymonosulfate Activation
Authors: Huang Yongkui , Kou Shuangwu , Zhang Xiaoting , Wang Lei , Lu Peili , Zhang Daijun
Published: April 2020

The rational fabrication of direct Z-scheme heterostructures photocatalysts is a pivotal strategy to boost the interfacial charge migration and separation. Herein, direct Z-scheme Bi2WO6/WO3 composites were rationally fabricated for the degradation of bisphenol A combined with the activation of peroxymonosulfate (PMS). The tight interface contact between Bi2WO6 and WO3 was successfully formed by the in situ epitaxial growth of ultrathin Bi2WO6 nanosheets at the surface of WO3 nanorods. The Bi2WO6/WO3 composite presented highly efficient catalytic performance toward degradation of BPA with PMS activation as compared to the WO3 and Bi2WO6. PMS can dramatically boost the photocatalytic activity of the composites. Moreover, the results of active radical scavenging experiments revealed that h+, •O2−, and •SO4− are critical active species in the photodegradation reaction. Finally, the photocatalytic mechanism for the degradation of BPA is also discussed in detail. The great improvement of photocatalytic performance should be ascribed to the effective formation of the direct Z-scheme heterojunctions between Bi2WO6 and WO3, resulting in improved light absorption, an efficient transfer and separation of photoinduced charge carriers, and a considerable amount of the electrons and holes with strong reduction and oxidation abilities. The study might provide new inspirations to design and construct heterostructured nanomaterials with outstanding photoactivity for environmental remediation.
Thermal Decomposition Behavior and Thermal Safety of Nitrocellulose with Different Shape CuO and Al/CuO Nanothermites
Authors: Yao Ergang , Zhao Ningning , Qin Zhao , Ma Haixia , Li Haijian , Xu Siyu , An Ting , Yi Jianhua , Zhao Fengqi
Published: April 2020

Bamboo leaf-like CuO(b) and flaky-shaped CuO(f) were prepared by the hydrothermal method, and then combined with Al nanoparticles to form Al/CuO(b) and Al/CuO(f) by the ultrasonic dispersion method. The phase, composition, morphology, and structure of the composites were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy scattering spectrometer (EDS). The compatibility of CuO, Al/CuO and nitrocellulose (NC) was evaluated by differential scanning calorimetry (DSC). The effects of CuO and Al/CuO on the thermal decomposition of NC were also studied. The results show that the thermal decomposition reactions of CuO-NC composite, Al/CuO-NC composite, and NC follow the same kinetic mechanism of Avrami-Erofeev equation. In the cases of CuO and Al/CuO, they could promote the O-NO2 bond cleavage and secondary autocatalytic reaction in condensed phase. The effects of these catalysts have some difference in modifying the thermolysis process of NC due to the microstructures of CuO and the addition of Al nanopowders. Furthermore, the presence of Al/CuO(f) can make the Al/CuO(f)-NC composite easier to ignite, whereas the composites have strong resistance to high temperature. Compatibility and thermal safety analysis showed that the Al/CuO had good compatibility with NC and it could be used safely. This contribution suggests that CuO and Al/CuO played key roles in accelerating the thermal decomposition of NC.
Double Metal Oxide Electron Transport Layers for Colloidal Quantum Dot Light-Emitting Diodes
Authors: Park Myeongjin , Roh Jeongkyun , Lim Jaehoon , Lee Hyunkoo , Lee Donggu
Published: April 2020

The performance of colloidal quantum dot light-emitting diodes (QD-LEDs) have been rapidly improved since metal oxide semiconductors were adopted for an electron transport layer (ETL). Among metal oxide semiconductors, zinc oxide (ZnO) has been the most generally employed for the ETL because of its excellent electron transport and injection properties. However, the ZnO ETL often yields charge imbalance in QD-LEDs, which results in undesirable device performance. Here, to address this issue, we introduce double metal oxide ETLs comprising ZnO and tin dioxide (SnO2) bilayer stacks. The employment of SnO2 for the second ETL significantly improves charge balance in the QD-LEDs by preventing spontaneous electron injection from the ZnO ETL and, as a result, we demonstrate 1.6 times higher luminescence efficiency in the QD-LEDs. This result suggests that the proposed double metal oxide ETLs can be a versatile platform for QD-based optoelectronic devices.
Titanium-Doped P-Type WO3 Thin Films for Liquefied Petroleum Gas Detection
Authors: He Yuzhenghan , Shi Xiaoyan , Chen Kyle , Yang Xiaohong , Chen Jun
Published: April 2020

Gas sensors are an important part of smart homes in the era of the Internet of Things. In this work, we studied Ti-doped P-type WO3 thin films for liquefied petroleum gas (LPG) sensors. Ti-doped tungsten oxide films were deposited on glass substrates by direct current reactive magnetron sputtering from a W-Ti alloy target at room temperature. After annealing at 450 °C in N2 ambient for 60 min, p-type Ti-doped WO3 was achieved for the first time. The measurement of the room temperature Hall-effect shows that the film has a resistivity of 5.223 × 103 Ωcm, a hole concentration of 9.227 × 1012 cm−3, and mobility of 1.295 × 102 cm2V−1s−1. X-Ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analyses reveal that the substitution of W6+ with Ti4+ resulted in p-type conductance. The scanning electron microscope (SEM) images show that the films consist of densely packed nanoparticles. The transmittance of the p-type films is between 72% and 84% in the visible spectra and the optical bandgap is 3.28 eV. The resistance increased when the films were exposed to the reducing gas of liquefied petroleum gas, further confirming the p-type conduction of the films. The p-type films have a quick response and recovery behavior to LPG.
The Interference Pattern of Plasmonic and Photonic Modes Manipulated by Slit Width
Authors: Li Xing , Tang Jing , Zhang Xuelian , Zhang Ruirui , Zeng Xiangyu , Zhan Zijun , Liu Chunxiang , Cheng Chuanfu
Published: April 2020

We demonstrate that the interference pattern of the plasmonic and photonic modes can be controlled by changing the slit width of a square slit structure. Based on the analyses of the plasmonic and photonic modes of slits with different widths, we theoretically derived the expressions of wavefield generated by a square slit. A far-field scattered imaging system is utilized to collect the intensity distribution experimentally. Various interference patterns, including stripes, square-like lattice array, and diamond-like lattice array, have been observed by adjusting the slit widths. In addition, the results were validated by performing finite-difference time-domain simulations, which are consistent with the theoretical and experimental results.
Polysaccharide-Based Bioink Formulation for 3D Bioprinting of an In Vitro Model of the Human Dermis
Authors: Zidarič Tanja , Milojević Marko , Gradišnik Lidija , Stana Kleinschek Karin , Maver Uroš , Maver Tina
Published: April 2020

Limitations in wound management have prompted scientists to introduce bioprinting techniques for creating constructs that can address clinical problems. The bioprinting approach is renowned for its ability to spatially control the three-dimensional (3D) placement of cells, molecules, and biomaterials. These features provide new possibilities to enhance homology to native skin and improve functional outcomes. However, for the clinical value, the development of hydrogel bioink with refined printability and bioactive properties is needed. In this study, we combined the outstanding viscoelastic behavior of nanofibrillated cellulose (NFC) with the fast cross-linking ability of alginate (ALG), carboxymethyl cellulose (CMC), and encapsulated human-derived skin fibroblasts (hSF) to create a bioink for the 3D bioprinting of a dermis layer. The shear thinning behavior of hSF-laden bioink enables construction of 3D scaffolds with high cell density and homogeneous cell distribution. The obtained results demonstrated that hSF-laden bioink supports cellular activity of hSF (up to 29 days) while offering proper printability in a biologically relevant 3D environment, making it a promising tool for skin tissue engineering and drug testing applications.
Electric Field Induced Dewetting of Hydrophobic Nanocavities at Ambient Temperature
Authors: Li Chenchao , Lin Dongdong , Zhao Wenhui
Published: April 2020

The understanding of water dewetting in nanoporous materials is of great importance in various fields of science and technology. Herein, we report molecular dynamics simulation results of dewetting of water droplet in hydrophobic nanocavities between graphene walls under the influence of electric field. At ambient temperature, the rate of dewetting induced by electric field is significantly large. Whereas, it is a very low rate of dewetting induced by high temperature (423 K) due to the strong interaction of the hydrogen-bonding networks of water droplets in nanocavities. In addition, the electric filed induced formation of a water column has been found in a vacuum chamber. When the electric field is turned off, the water column will transform into a water droplet. Importantly, the results demonstrate that the rate of electric field-induced dewetting increases with growth of the electric field. Overall, our results suggest that electric field may have a great potential application for nanomaterial dewetting.
Toxicity and Functional Impairment in Human Adipose Tissue-Derived Stromal Cells (hASCs) Following Long-Term Exposure to Very Small Iron Oxide Particles (VSOPs)
Authors: Radeloff Katrin , Radeloff Andreas , Ramos Tirado Mario , Scherzad Agmal , Hagen Rudolf , Kleinsasser Norbert H. , Hackenberg Stephan
Published: April 2020

Magnetic nanoparticles (NPs), such as very small iron oxide NPs (VSOPs) can be used for targeted drug delivery, cancer treatment or tissue engineering. Another important field of application is the labelling of mesenchymal stem cells to allow in vivo tracking and visualization of transplanted cells using magnetic resonance imaging (MRI). For these NPs, however, various toxic effects, as well as functional impairment of the exposed cells, are described. The present study evaluates the influence of VSOPs on the multilineage differentiation ability and cytokine secretion of human adipose tissue derived stromal cells (hASCs) after long-term exposure. Human ASCs were labelled with VSOPs, and the efficacy of the labelling was documented over 4 weeks in vitro cultivation of the labelled cells. Unlabelled hASCs served as negative controls. Four weeks after labelling, adipogenic and osteogenic differentiation was histologically evaluated and quantified by polymerase chain reaction (PCR). Changes in gene expression of IL-6, IL-8, VEGF and caspase 3 were determined over 4 weeks. Four weeks after the labelling procedure, labelled and unlabelled hASCs did not differ in the gene expression of IL-6, IL-8, VEGF and caspase 3. Furthermore, the labelling procedure had no influence on the multidifferentiation ability of hASC. The percentage of labelled cells decreased during in vitro expansion over 4 weeks. Labelling with VSOPs and long-term intracellular disposition probably have no influence on the physiological functions of hASCs. This could be important for the future in vivo use of iron oxide NPs.
Nutritional Status and Risk Factors for Frailty in Community-Dwelling Older People: A Cross-Sectional Study
Authors: Pérez-Ros Pilar , Vila-Candel Rafael , López-Hernández Lourdes , Martínez-Arnau Francisco Miguel
Published: April 2020

Objective: This study aims to assess the relationship that frailty has with nutritional status and functional risk factors in community-dwelling older adults. Methods: Cross-sectional study in community-dwelling older people, independent for walking and without impaired cognition. Frailty was assessed by Fried criteria. Nutritional status was analyzed by the Mini Nutritional Assessment Short Form (MNA-SF), biochemical markers (albumin, total proteins, cholesterol, lymphocytes, and hemoglobin); and anthropometric parameters (body mass index [BMI], body fat percentage, handgrip, and perimeters). A comprehensive geriatric assessment analyzed other risk factors: functionality, cognition, falls, comorbidity, polypharmacy, physical activity, and quality of life (QoL). Results: We included 564 elderly people with a mean age of 76.05 (standard deviation 3.97) years; 63.1% (n = 356) were women, and 83.9% (n = 473) were prefrail, and frail. The sample presented high functionality and a nutritional status with a predominance of overweight and obesity. Factors associated with frailty (R2 = 0.43) were age over 75 years (odds ratio [OR] 3.31, 95% confidence interval [CI] 1.76, 6.21; p < 0.001), female gender (OR 2.37, 95% CI 1.24, 4.52; p = 0.009), anemia (OR 2.45, 95% CI 1.19, 5.02; p = 0.015), falls (OR 1.94, 95% CI 1.12, 3.25; p = 0.016) and the fear of falling (OR 4.01: 95% CI 1.76, 9.16; p = 0.001). Performing more than 3 weekly hours of physical activity was found to be a protective factor (OR 0.23, 95% CI 0.15, 0.35; p < 0.001). Conclusions: The relationship between frailty and malnutrition in functionally independent community-dwelling older people is unclear. More studies are needed to know what nutritional markers are related to frailty, cognition, and functionality in order to discriminate the risk factors for community-dwelling older people at risk of malnutrition and dependency.
Feasibility of the AusMed Diet Program: Translating the Mediterranean Diet for Older Australians
Authors: Zacharia Karly , Patterson Amanda J. , English Coralie , MacDonald-Wicks Lesley
Published: April 2020

The Mediterranean diet pattern (MEDI) is associated with a lower risk of chronic conditions related to ageing. Adherence research mostly comes from Mediterranean countries with high cultural acceptability. This study examines the feasibility of a MEDI intervention designed specifically for older Australians (AusMed). Phase 1 involved a consumer research group (n = 17) presentation of program materials with surveys after each section. In-depth individual semi-structured interviews (n = 6) were then conducted. All participants reported increased knowledge and confidence in adherence to the MEDI, with the majority preferring a booklet format (70%) and group delivery (58%). Three themes emerged from interviews—1. barriers (complexity, perceived cost and food preferences), 2. additional support and 3. individualisation of materials. Program materials were modified accordingly. Phase 2 was a 2-week trial of the modified program (n = 15). Participants received a group counselling session, program manual and food hamper. Adherence to the MEDI was measured by the Mediterranean Diet Score (MDS). All participants increased their adherence after the 2-week trial, from a mean score of 5.4 ± 2.4 (low adherence) to a mean score of 9.6 ± 2.0 (moderate to high adherence). All found that text message support helped achieve their goals and were confident to continue the dietary change.
Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life
Authors: Kleist Sierra A. , Knoop Kathryn A.
Published: April 2020

Late-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the long-term. Though the known benefits of an exclusive mother’s own milk diet in early life have been well recognized and described, it is less understood how breastfed infants enjoy a potential reduction in risk of LOS and other systemic infections. Here we review how gut residing pathogens within the intestinal microbiota of infants can cause a subset of sepsis cases and the components of breastmilk that may prevent the dissemination of pathogens from the intestine.
Consuming Gymnema sylvestre Reduces the Desire for High-Sugar Sweet Foods
Authors: Turner Sophie , Diako Charles , Kruger Rozanne , Wong Marie , Wood Warrick , Rutherfurd-Markwick Kay , Ali Ajmol
Published: April 2020

Background. Gymnemic acids, from the plant Gymnema sylvestre (GS), selectively suppress taste responses to sweet compounds without affecting the perception of other taste elements. The aim of this study was to investigate the effect of consuming a GS-containing mint on the desire to consume high-sugar sweet foods directly thereafter. Methods. This study utilized a single-blind, crossover design comparing the consumption of a mint (dissolving tablet) containing 4 mg of gymnemic acids with an isocaloric placebo in 56 healthy young men and women. Participants were given samples of their favourite chocolate (varied between 14–18 g; energy varied between 292–370 kJ) and were directed to rate on their hunger on 100-mm visual analogue scales 30 s prior to consuming high-sugar sweet food (chocolate). They then consumed the GS mint or placebo mint and rated their perceived pleasantness and desire for more chocolate on separate visual analogue scales immediately following consumption of the high-sugar sweet food before being offered up to five additional servings (and asked to rate hunger, pleasantness and desire to eat more chocolate between each ingestion period). Results. The number of chocolate bars eaten decreased by 0.48 bars (21.3%) within a 15-min period of consumption of the GS mint (p = 0.006). Desire to eat more of the high-sugar sweet food (p = 0.011) and pleasantness of the high-sugar sweet food (p < 0.001) was reduced after GS mint intake. Those who reported having a ‘sweet tooth’ had a greater reduction in the pleasantness of chocolate (p = 0.037) and desire to eat more (p = 0.004) after consuming the GS mint for the first serving of a high-sugar sweet food following the mint. Conclusion. Consuming gymnema-containing mints compared to placebo significantly reduced the quantity of chocolate eaten mainly due to a decrease in the desire and pleasantness of consuming it.
The Role of Selenium in Health and Disease: Emerging and Recurring Trends
Authors: Méplan Catherine , Hughes David J.
Published: April 2020

In this Special Issue of Nutrients, “The Role of Selenium in Health and Disease” covers diverse diseases in the 8 original research articles and 2 reviews, such as cardiovascular disorders (CVD), metabolic syndrome, obesity, cancer, and viral infection, and highlights novel potential biomarkers of disease risk and prognosis [...]
Dietary Diversity and All-Cause and Cause-Specific Mortality in Japanese Community-Dwelling Older Adults
Authors: Otsuka Rei , Tange Chikako , Nishita Yukiko , Kato Yuki , Tomida Makiko , Imai Tomoko , Ando Fujiko , Shimokata Hiroshi
Published: April 2020

We examined associations between dietary diversity and all-cause and cause-specific mortality in 386 men and 413 women (age range, 60–79 years at baseline) who took part in the National Institute for Longevity Sciences-Longitudinal Study of Aging study from 1997 to 2000. Dietary intake was assessed using three-day dietary records and photographs. The Quantitative Index for Dietary Diversity was used to determine the dietary diversity among thirteen food groups. Dietary diversity score and each food intake were examined by sex-stratified tertiles, and hazard ratios (HR) were calculated to compare the risk for all-cause and cause-specific deaths across tertiles, after controlling for age, sex, body mass index, alcohol intake, smoking status, education, physical activity, and disease history. During a mean follow-up of 15.7 years, 289 subjects (36.2%) died. Compared to the subjects in the lowest tertile, the multivariate-adjusted HR for all-cause and cancer mortality was 0.69 (95% confidence interval (CI): 0.51–0.94) and 0.57 (95% CI: 0.33–0.98), respectively (trend p < 0.05), in subjects in the highest tertile of dietary diversity. There were no significant associations between dietary diversity score and death from cardiovascular or cerebrovascular disease. Eating a variety of foods might contribute to longevity in older Japanese community dwellers.
Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort
Authors: Ferraris Celeste , Turner Alexandria , Kaur Kiranjit , Piper Jessica , Veysey Martin , Lucock Mark , Beckett Emma L.
Published: April 2020

A small amount of emerging research has observed variations between individual sensitivity, preference and intake of salt in the presence of single nucleotide polymorphisms (SNP) on the genes encoding salt taste receptors. Sodium intake is a significant risk factor for common diseases in elderly populations such as hypertension and cardiovascular disease; however, this does not fully explain the risk. Research into the influence of salt taste genetics on diet quality is yet to be undertaken and current research on indicators of health is limited and mixed in the direction of associations. Therefore, a secondary analysis of data from a well-characterised elderly cohort (the cross-sectional Retirement Health and Lifestyle Study, n = 536) was conducted to explore relationships between the salt taste-related SNP TRPV1-rs8065080 (assessed by Taqman genotyping assay), dietary habits and biomarkers of health. Data were analysed with standard least squares regression modelling and Tukey’s HSD post hoc tests. No association was found between the TRPV1-rs8065080 genotype, sodium intake or multiple diet quality indices (assessed by food frequency questionnaire). Sodium-related markers of health including blood pressure and markers of kidney function (urinary creatinine and albumin/creatinine ratio) and general health markers, such as Body Mass Index (BMI), were also not related to TRPV1-rs8065080 genotype. To date, this study is the most comprehensive investigation conducted to determine if the TRPV1-rs8065080 genotype relates to sodium intake and health markers influenced by sodium intake. Although no significant relationships were found, these findings are an important contribution to the limited body of knowledge surround this SNP. In addition to further research across other ages and cultures, the TRPV1-rs8065080 genotype may interact with other ion channels, and so further studies are required to determine if polymorphic variations influence sodium intake, diet and health.
Galacto-Oligosaccharide RP-G28 Improves Multiple Clinical Outcomes in Lactose-Intolerant Patients
Authors: Chey William , Sandborn William , Ritter Andrew J. , Foyt Howard , Azcarate-Peril M. Andrea , Savaiano Dennis A.
Published: April 2020

Background and Aims: Lactose intolerance (LI) is a global problem affecting more than half of the world’s population. An ultra-purified, high-concentration galacto-oligosaccharide, RP-G28, is being developed as a treatment for patients with LI. The efficacy and safety of RP-G28 in reducing symptoms of lactose intolerance were assessed in a blinded, randomized, placebo-controlled trial. Methods: In this multiclinical site, double-blinded, placebo-controlled trial, 377 patients with LI were randomized to one of two doses of orally administered RP-G28 or placebo for 30 days. A LI test and symptom assessment were performed at baseline and on day 31. The primary endpoint was a ≥4-point reduction or a score of zero on LI composite score on day 31. Voluntary milk and dairy intake and global outcome measures assessed patients’ overall treatment satisfaction and quality of life before therapy and 30 days after therapy. This study received Institutional Review Board (IRB) approval. Results: For the primary endpoint, 40% in the RP-G28 groups reported a ≥4-point reduction or no symptoms on LI symptom composite score compared to 26% with placebo (p = 0.016). Treatment with RP-G28 also led to significantly higher levels of milk and dairy intake and significant improvements in global assessments compared to placebo. RP-G28 but not placebo led to significant increases in five Bifidobacterium taxa. Conclusions: RP-G28 for 30 days significantly reduced symptoms and altered the fecal microbiome in patients with LI. Treatment with RP-G28 also improved milk/dairy consumption and quality of life and was safe and well tolerated.
Urtica dioica Whole Vegetable as a Functional Food Targeting Fat Accumulation and Insulin Resistance-a Preliminary Study in a Mouse Pre-Diabetic Model
Authors: Fan Si , Raychaudhuri Samnhita , Kraus Olivia , Shahinozzaman Md , Lofti Leila , Obanda Diana N.
Published: April 2020

The shoot of Urtica dioica is used in several cultures as a vegetable or herb. However, not much has been studied about the potential of this plant when consumed as a whole food/vegetable rather than an extract for dietary supplements. In a 12-week dietary intervention study, we tested the effect of U. dioica vegetable on high fat diet induced obesity and insulin resistance in C57BL/6J mice. Mice were fed ad libitum with isocaloric diets containing 10% fat or 45% fat with or without U. dioica. The diet supplemented with U. dioica attenuated high fat diet induced weight gain (p < 0.005; n = 9), fat accumulation in adipose tissue (p < 0.005; n = 9), and whole-body insulin resistance (HOMA-IR index) (p < 0.001; n = 9). Analysis of gene expression in skeletal muscle showed no effect on the constituents of the insulin signaling pathway (AKT, IRS proteins, PI3K, GLUT4, and insulin receptor). Notable genes that impact lipid or glucose metabolism and whose expression was changed by U. dioica include fasting induced adipocyte factor (FIAF) in adipose and skeletal muscle, peroxisome proliferator-activated receptor-α (Ppar-α) and forkhead box protein (FOXO1) in muscle and liver, and Carnitine palmitoyltransferase I (Cpt1) in liver (p < 0.01). We conclude that U. dioica vegetable protects against diet induced obesity through mechanisms involving lipid accumulation and glucose metabolism in skeletal muscle, liver, and adipose tissue.
The Long-Term Safety and Quality of Life Effects of Oats in Dermatitis Herpetiformis
Authors: Alakoski Anna , Hervonen Kaisa , Mansikka Eriika , Reunala Timo , Kaukinen Katri , Kivelä Laura , Laurikka Pilvi , Huhtala Heini , Kurppa Kalle , Salmi Teea
Published: April 2020

The treatment of choice for dermatitis herpetiformis (DH), a cutaneous manifestation of coeliac disease, is a life-long gluten-free diet (GFD). In a GFD, wheat, rye and barley should be strictly avoided, but the role of oats is more controversial. This study aimed to investigate the safety and long-term quality of life and health effects of oat consumption in 312 long-term treated DH patients. Baseline data were gathered from patient records and follow-up data from questionnaires or interviews, and validated questionnaires were used to assess quality of life. We found that altogether 256 patients (82%) were consuming oats as part of their GFD at the follow-up. Long-term follow-up data showed that there were no differences in the presence of long-term illnesses, coeliac disease complications or the usage of medication between those consuming and not consuming oats. However, oat consumers had a better quality of life and reported ongoing gastrointestinal symptoms less frequently (4% vs 19%, p = 0.004) at the follow-up than those not consuming oats. The study established that oats are safe for DH patients and in the long-term seem to improve the quality of life of DH patients.
Leucine-Enriched Essential Amino Acids Improve Recovery from Post-Exercise Muscle Damage Independent of Increases in Integrated Myofibrillar Protein Synthesis in Young Men
Authors: Waskiw-Ford Marcus , Hannaian Sarkis , Duncan Justin , Kato Hiroyuki , Abou Sawan Sidney , Locke Marius , Kumbhare Dinesh , Moore Daniel
Published: April 2020

Background: Leucine-enriched essential amino acids (LEAAs) acutely enhance post-exercise myofibrillar protein synthesis (MyoPS), which has been suggested to be important for muscle repair and recovery. However, the ability of LEAAs to concurrently enhance MyoPS and muscle damage recovery in free-living humans has not been studied. Methods: In a randomized, double-blind, placebo-controlled, parallel-group design, twenty recreationally active males consuming a controlled diet (1.2 g/kg/d of protein) were supplemented thrice daily with 4 g of LEAAs (containing 1.6 g leucine) or isocaloric placebo for four days following an acute bout of lower-body resistance exercise (RE). MyoPS at rest and integrated over 96 h of recovery was measured by D2O. Isometric and isokinetic torque, muscle soreness, Z-band streaming, muscle heat shock protein (HSP) 25 and 72, plasma creatine kinase (CK), and plasma interleukin-6 (IL-6) were measured over 96 h post-RE to assess various direct and indirect markers of muscle damage. Results: Integrated MyoPS increased ~72% over 96 h after RE (p < 0.05), with no differences between groups (p = 0.98). Isometric, isokinetic, and total peak torque decreased ~21% by 48 h after RE (p < 0.05), whereas total peak torque was ~10% greater overall during recovery in LEAAs compared to placebo (p < 0.05). There were moderate to large effects for peak torque in favour of LEAAs. Muscle soreness increased during recovery with no statistical differences between groups but small to moderate effects in favour of LEAAs that correlated with changes in peak torque. Plasma CK, plasma IL-6, and muscle HSP25 increased after RE (p < 0.05) but were not significantly different between groups (p ≥ 0.13). Consistent with a trend toward attenuated Z-band streaming in LEAAs (p = 0.07), muscle HSP72 expression was lower (p < 0.05) during recovery in LEAAs compared with placebo. There were no correlations between MyoPS and any measures of muscle damage (p ≥ 0.37). Conclusion: Collectively, our data suggest that LEAAs moderately attenuated muscle damage without concomitant increases in integrated MyoPS in the days following an acute bout of resistance exercise in free-living recreationally active men.
Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases
Authors: Mirabelli Maria , Chiefari Eusebio , Arcidiacono Biagio , Corigliano Domenica Maria , Brunetti Francesco Saverio , Maggisano Valentina , Russo Diego , Foti Daniela Patrizia , Brunetti Antonio
Published: April 2020

Insulin resistance (IR), defined as an attenuated biological response to circulating insulin, is a fundamental defect in obesity and type 2 diabetes (T2D), and is also linked to a wide spectrum of pathological conditions, such as non-alcoholic fatty liver disease (NAFLD), cognitive impairment, endothelial dysfunction, chronic kidney disease (CKD), polycystic ovary syndrome (PCOS), and some endocrine tumors, including breast cancer. In obesity, the unbalanced production of pro- and anti-inflammatory adipocytokines can lead to the development of IR and its related metabolic complications, which are potentially reversible through weight-loss programs. The Mediterranean diet (MedDiet), characterized by high consumption of extra-virgin olive oil (EVOO), nuts, red wine, vegetables and other polyphenol-rich elements, has proved to be associated with greater improvement of IR in obese individuals, when compared to other nutritional interventions. Also, recent studies in either experimental animal models or in humans, have shown encouraging results for insulin-sensitizing nutritional supplements derived from MedDiet food sources in the modulation of pathognomonic traits of certain IR-related conditions, including polyunsaturated fatty acids from olive oil and seeds, anthocyanins from purple vegetables and fruits, resveratrol from grapes, and the EVOO-derived, oleacein. Although the pharmacological properties and clinical uses of these functional nutrients are still under investigation, the molecular mechanism(s) underlying the metabolic benefits appear to be compound-specific and, in some cases, point to a role in gene expression through an involvement of the nuclear high-mobility group A1 (HMGA1) protein.
Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite
Authors: Brodin Ola , Hackler Julian , Misra Sougat , Wendt Sebastian , Sun Qian , Laaf Elena , Stoppe Christian , Björnstedt Mikael , Schomburg Lutz
Published: April 2020

Selenoprotein P (SELENOP) is an established biomarker of selenium (Se) status. Serum SELENOP becomes saturated with increasing Se intake, reaching maximal concentrations of 5–7 mg SELENOP/L at intakes of ca. 100–150 µg Se/d. A biomarker for higher Se intake is missing. We hypothesized that SELENOP may also reflect Se status in clinical applications of therapeutic dosages of selenite. To this end, blood samples from two supplementation studies employing intravenous application of selenite at dosages >1 mg/d were analyzed. Total Se was quantified by spectroscopy, and SELENOP by a validated ELISA. The high dosage selenite infusions increased SELENOP in parallel to elevated Se concentrations relatively fast to final values partly exceeding 10 mg SELENOP/L. Age or sex were not related to the SELENOP increase. Western blot analyses of SELENOP verified the results obtained by ELISA, and indicated an unchanged pattern of immunoreactive protein isoforms. We conclude that the saturation of SELENOP concentrations observed in prior studies with moderate Se dosages (<400 µg/d) may reflect an intermediate plateau of expression, rather than an absolute upper limit. Circulating SELENOP seems to be a suitable biomarker for therapeutic applications of selenite exceeding the recommended upper intake levels. Whether SELENOP is also capable of reflecting other supplemental selenocompounds in high dosage therapeutic applications remains to be investigated.
Racial and Sex Differences in 24 Hour Urinary Hydration Markers among Male and Female Emerging Adults: A Pilot Study
Authors: Adams William M. , Hevel Derek J. , Maher Jaclyn P. , McGuirt Jared T.
Published: April 2020

The purpose of this study was to examine 24 h urinary hydration markers in non-Hispanic White (WH) and non-Hispanic Black (BL) males and females. Thirteen males (BL, n = 6; WH, n = 7) and nineteen females (BL, n = 16, WH, n = 3) (mean ± SD; age, 20 ± 4 y; height, 169.2 ± 12.2 cm; body mass, 71.3 ± 12.2 kg; body fat, 20.8 ± 9.7%) provided a 24 h urine sample across 7 (n = 13) or 3 (n = 19) consecutive days (148 d total) for assessment of urine volume (UVOL), urine osmolality (UOSM), urine specific gravity (USG), and urine color (UCOL). UVOL was significantly lower in BL (0.85 ± 0.43 L) compared to WH college students (2.03 ± 0.70 L) (p < 0.001). Measures of UOSM, USG, and UCOL, were significantly greater in BL (716 ± 263 mOsm∙kg−1, 1.020 ± 0.007, and 4.2 ± 1.4, respectively) compared to WH college students (473 ± 194 mOsm∙kg−1, 1.013 ± 0.006, 3.0 ± 1.2, and respectively) (p < 0.05). Differences in 24 h urinary hydration measures were not significantly different between males and females (p > 0.05) or between the interaction of sex and race/ethnicity (p > 0.05). Non-Hispanic Black men and women were inadequately hydrated compared to their non-Hispanic White counterparts. Our findings suggest that development of targeted strategies to improve habitual fluid intake and potentially overall health are needed.
The Efficacy of Polyunsaturated Fatty Acids as Protectors against Calcium Oxalate Renal Stone Formation: A Review
Authors: Rodgers Allen L. , Siener Roswitha
Published: April 2020

In the pathogenesis of hypercalciuria and hyperoxaluria, n-6 polyunsaturated fatty acids (PUFAs) have been implicated by virtue of their metabolic links with arachidonic acid (AA) and prostaglandin PGE2. Studies have also shown that n-3 PUFAs, particularly those in fish oil—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—can serve as competitive substrates for AA in the n-6 series and can be incorporated into cell membrane phospholipids in the latter’s place, thereby reducing urinary excretions of calcium and oxalate. The present review interrogates several different types of study which address the question of the potential roles played by dietary PUFAs in modulating stone formation. Included among these are human trials that have investigated the effects of dietary PUFA interventions. We identified 16 such trials. Besides fish oil (EPA+DHA), other supplements such as evening primrose oil containing n-6 FAs linoleic acid (LA) and γ-linolenic acid (GLA) were tested. Urinary excretion of calcium or oxalate or both decreased in most trials. However, these decreases were most prominent in the fish oil trials. We recommend the administration of fish oil containing EPA and DHA in the management of calcium oxalate urolithiasis.
Trace Mineral Intake and Deficiencies in Older Adults Living in the Community and Institutions: A Systematic Review
Authors: Vural Zeynep , Avery Amanda , Kalogiros Dimitris I. , Coneyworth Lisa J. , Welham Simon J. M.
Published: April 2020

The global population is ageing with many older adults suffering from age-related malnutrition, including micronutrient deficiencies. Adequate nutrient intake is vital to enable older adults to continue living independently and delay their institutionalisation, as well as to prevent deterioration of health status in those living in institutions. This systematic review investigated the insufficiency of trace minerals in older adults living independently and in institutions. We examined 28 studies following a cross-sectional or cohort design, including 7203 older adults (≥60) living independently in 13 Western countries and 2036 living in institutions in seven Western countries. The estimated average requirement (EAR) cut-off point method was used to calculate percentage insufficiency for eight trace minerals using extracted mean and standard deviation values. Zinc deficiency was observed in 31% of community-based women and 49% of men. This was higher for those in institutional care (50% and 66%, respectively). Selenium intakes were similarly compromised with deficiency in 49% women and 37% men in the community and 44% women and 27% men in institutions. We additionally found significant proportions of both populations showing insufficiency for iron, iodine and copper. This paper identifies consistent nutritional insufficiency for selenium, zinc, iodine and copper in older adults.
Controlling Nutritional Status (CONUT) Score is Associated with Overall Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Cohort Study
Authors: Shimose Shigeo , Kawaguchi Takumi , Iwamoto Hideki , Tanaka Masatoshi , Miyazaki Ken , Ono Miki , Niizeki Takashi , Shirono Tomotake , Okamura Shusuke , Nakano Masahito , Suga Hideya , Yamaguchi Taizo , Yokokura Yoshinori , Noguchi Kazunori , Koga Hironori , Torimura Takuji
Published: April 2020

We aimed to investigate the impact of the controlling nutritional status (CONUT) score, an immuno-nutritional biomarker, on the prognosis of patients with hepatocellular carcinoma (HCC) treated with lenvatinib (LEN). This retrospective study enrolled 164 patients with HCC and treated with LEN (median age 73 years, Barcelona Clinic Liver Cancer (BCLC) stage B/C 93/71). Factors associated with overall survival (OS) were evaluated using multivariate and decision tree analyses. OS was calculated using the Kaplan–Meier method and analyzed using the log–rank test. Independent factors for OS were albumin–bilirubin grade 1, BCLC stage B, and CONUT score <5 (hazard ratio (HR) 2.9, 95% confidence interval (CI) 1.58–5.31, p < 0.001). The CONUT score was the most important variable for OS, with OS rates of 70.0% and 29.0% in the low and high CONUT groups, respectively. Additionally, the median survival time was longer in the low CONUT group than in the high CONUT group (median survival time not reached vs. 11.3 months, p < 0.001). The CONUT score was the most important prognostic variable, rather than albumin–bilirubin grade and BCLC stage, in patients with HCC treated with LEN. Accordingly, immuno-nutritional status may be an important factor in the management of patients with HCC treated with LEN.
Critical Behavior of (2 + 1)-Dimensional QED: 1/N Expansion
Authors: Kotikov Anatoly V. , Teber Sofian
Published: April 2020

We present recent results on dynamical chiral symmetry breaking in (2 + 1)-dimensional QED with N four-component fermions. The results of the 1 / N expansion in the leading and next-to-leading orders were found exactly in an arbitrary nonlocal gauge.
In Vitro Bactericidal Effects of Photodynamic Therapy Combined with Four Tetracyclines against Clostridioides difficile KCTC5009 in Planktonic Cultures
Authors: Choi Sung Sook , Oh Hui Yeong , Kim Eui Jin , Lee Hae Kyung , Kim Hyung Keun , Choi Hyun Ho , Kim Sang Woo , Chae Hiun Suk
Published: April 2020

Surface disinfection in health-care facilities is critical to prevent dissemination of Clostridioides difficile (C. difficile). Tetracyclines (TCs) are broad-spectrum antibiotics that are associated with a low risk of development of C. difficile infection (CDI) and are used as photosensitizers (PS) in photodynamic therapy (PDT). We evaluated whether TCs may be useful environmental cleansing agents. We compared the in vitro ability to kill C. difficile of four TCs (TC, doxycycline, minocycline, and tigecycline) combined with PDT using ultraviolet A (UVA). We included chitosan, a cationic material, as a booster to increase the photodynamic bactericidal efficacy of TCs. PDT-induced bactericidal effects were assessed by the number of viable cells and the degree of DNA damage and membrane integrity. To avoid the intrinsic antibacterial activity of TCs at high concentrations, we used low concentrations of TCs (0.05 and 0.1 mg/mL). The bactericidal effect of treatment with chitosan plus PDT was over 100 times higher than that with PDT alone for each of the four TCs. DNA damage measured by ethidium bromide monoazide and real-time quantitative polymerase chain reaction was also greater for PDT plus chitosan treatment than for PDT alone or under control conditions: the threshold cycle (Ct) values for the control, PDT, and PDT plus chitosan were 14.67 ± 0.22, 20.46 ± 0.12, and 25.54 ± 0.17, respectively. All four TCs caused similar levels of severe cell membrane damage during PDT compared with control conditions. These data suggest that PDT combined with any of the four TCs plus chitosan might be an available tool to kill efficiently planktonic form of C. difficile.
The IDF Military Rabbi: Between a “Kohen Anointed for War” and a “Religious Services Provider”
Authors: Kampinsky Aharon (roni)
Published: April 2020

Military rabbis in the Israel Defense Forces (IDF) are an integral part of the army and currently posted in almost all army units. The role of the military rabbi has undergone fundamental changes since the founding of the State and the IDF, most notably in the past generation. While the formal definition of the military rabbi’s role has remained relatively stable; in practice it has undergone dramatic changes on the backdrop of processes in the IDF Military Rabbinate and in the religious-Zionist sector in Israel. Whereas in the past military rabbis were viewed as religious service providers, during the term of Chief Military Rabbi Rontzky (2010–2016) they viewed themselves in the role of a “Kohen anointed for war” (Meshuach Milchama). Harking back to the biblical description of the Kohanim who strengthen the people at a time of war, this military figure is entrusted with strengthening soldiers, morally and spiritually, before they go into battle. Nonetheless, a return to the religious services provider model can be discerned in recent years, mainly in response to the contention of religionization in the military. The article focuses on the changing role of the IDF military rabbi and identifies three major explanatory factors of these changes: (a) Differences between the formative period of the IDF Military Rabbinate and later periods; (b) Demographic changes in the composition of the IDF, mainly the growing number of soldiers from the national-religious sector; (c) The changing character of the Chief Military Rabbi’s background which affected the nature of the military rabbi’s role. The article aims to show that the Military Rabbinate has not been immune to the struggle over the collective Jewish identity of the State of Israel, and its underlying processes reflect the complexity and diversity of Israeli society.
The Brahmin, the Aryan, and the Powers of the Priestly Class: Puzzles in the Study of Indian Religion
Authors: Keppens Marianne , De Roover Jakob
Published: April 2020

The classical account of the Brahmin priestly class and its role in Indian religion has seen remarkable continuity during the past two centuries. Its core claims appear to remain unaffected, despite the major shifts that occurred in the theorizing of Indian culture and in the study of religion. In this article, we first examine the issue of the power and status of the Brahmin and show how it generates explanatory puzzles today. We then turn to 18th- and 19th-century sources to identify the cognitive conditions which sustained the classical account of the Brahmin priest and allowed for its transmission. Three clusters of concepts were crucial here: Christian-theological ideas concerning heathen priesthood and idolatry; racial notions of biological and cultural superiority and inferiority; and anthropological speculations about ‘primitive man’ and his ‘magical thinking’. While all three clusters were rejected by 20th- and 21st-century scholarship, the related claims about Brahmanical ritual power continue to be presented as facts. What accounts for this peculiar combination of continuities and discontinuities in the study of (ancient) Indian religion? We turn to some insights from the philosophy of science to sketch a route toward answering this question.
Spirituality and Organizations: A Proposal for a New Company Style Based on a Systematic Review of Literature
Authors: Vila Porras Carolina , Toro-Jaramillo Iván-Darío
Published: April 2020

The purpose of this research is to propose a new company style based on a systematic review of literature, taking the Matthean beatitudes as a reference in relation to the actual needs of organizations. To such end, we searched for scientific articles in Scopus, Web of Science, EBSCO, and ATLA databases. A considerable number of investigations were found on spirituality in organizations, but none specifically covered the biblical area. This study aims to suggest ways through which the human being can be at the center of organizations for a new style of business to emerge.
Clearing the Course: Folio 348 of the Nepalese Gaṇḍavyūha-sūtra in the Cleveland Museum of Art
Authors: Mace Sonya Rhie
Published: April 2020

The final 15 folios of the Nepalese illuminated palm-leaf manuscript of the Sanskrit Gaṇḍavyūha-sūtra of c. 1100 have more paintings per page, larger picture planes, and different types of scenes than are found on the leaves surviving from the first 340 folios. One example is Folio 348 in the Cleveland Museum of Art, which has been painted with scenes of a bodhisattva tossing a blue-skinned heretic, an unusual image of a monk or upāsika wearing blue robes, and a Vajrācārya priest setting a Hindu rishi ablaze. From the point of view of the Mahāyāna Buddhist makers of this manuscript, these figures may personify the wrong views that derail pilgrims on the bodhisattva path to enlightenment. The dramatic shift in imagery appears to reflect the transition from the end of the inspirational pilgrimage of Sudhana to the popular, protective dhāraṇī verses of the Bhadracarī that form the finale to the text. The scenes of destruction and elimination of heretical figures correspond with sentiments in the Bhadracarī, indicating that the artists understood the structure and content of the text.