bluuebunny/crossref_metadata_2025 huggingface dataset:
A multilevel investigation to reveal the regulatory mechanism of lignin accumulation in juice sac granulation of pomelo
Authors: LIU Luning , Chen YiRan , Wu Weilin , Chen Qiuyou , Tian ZhiJiao , Huang JiaKang , Ren HuaQing , Zhang JiaCheng , Du Xi , Zhuang Mulai , Wang Ping
Published: February 2024

Granulation of juice sacs is a physiological disorder, which affects pomelo fruit quality. Here, the transcriptome and ubiquitinome of the granulated juice sacs were analyzed in Guanxi pomelo. We found that lignin accumulation in the granulated juice sacs was regulated at transcription and protein modification levels. In transcriptome data, we found that the genes in lignin biosynthesis pathway and antioxidant enzyme system of the granulated juice sacs were significantly up-regulated. However, in ubiquitinome data, we found that ubiquitinated antioxidant enzymes increased in abundance but the enzyme activities decreased after the modification, which gave rise to reactive oxygen species (ROS) contents in granulated juice sacs. This finding suggests that ubiquitination level of the antioxidant enzymes is negatively correlated with the enzyme activities. Increased H2O2 is considered to be a signalling molecule to activate the key gene expressions in lignin biosynthesis pathway, which leads to the lignification in granulated juice sacs of pomelo. This regulatory mechanism in juice sac granulation of pomelo was further confirmed through the verification experiment using tissue culture by adding H2O2 or dimethylthiourea (DMTU). Our findings suggest that scavenging H2O2 and other ROS are important for reducing lignin accumulation, alleviating juice sac granulation and improving pomelo fruit quality.
Factors that influence knowledge workers’ communication on social-media: Self-efficacy as mediator
Authors: Turmudi Hamzah
Published: February 2024

Purpose
Social-media (SM) usage has developed to be a vital element of information research. Workers who use SM to post job-associated content are regarded as reliable informants and significantly affect the perceptions of prospective consumers and upcoming workers in the company. Thus, workers’ capability of communicating their jobs through SM has developed to be a viable benefit for other workers and companies, especially in the specialized service industry. Consequently, comprehending the impact of workers’ capability to employ SM proficiently is vital for recognizing the communication conducts of modern intelligent workers. The paper examines factors that influence self-efficacy (SE) in workers’ job-associated communication on social media (CSM).
Methodology
This study uses a quantitative method. Data was gathered from employees in five types of Halal service companies in Indonesia. Participants working in those firms were portrayed as ‘knowledge workers’, who were differentiated by their concentration on “non-routine” decision-making, creative and divergent thinking, and problem-solving.
Findings
This study’s findings reveal that observed company support, SM coaching, and earlier practical knowledge with SM are influential determinants of SE and then job-associated CSM. Therefore, companies and managers possess some factors immediately inside the extent of their power that can help workers participate in the expert usage of SM.
Originality
This study is an initial effort to examine the mentioned inter-variable relationships in the new context of knowledge workers in emerging countries such as Indonesia. The research supports the existing research regarding workers’ communicative conduct and delivers vital and practical comprehensions to enhance and manage human capital.
Determining Hydrocephalus and V-P Shunt Requirements After Repair of Myelomeningocele and Myeloschisis Defects in Infants
Authors: ŞERİFOĞLU LUAY , ETLİ MUSTAFA UMUT , Işık Semra , Seçkin Murat sait , öndünç gonca gül , karaaslanlı abdulmutalip
Published: February 2024

Aim Myelomeningocele (MM) and Myeloschisis (MS) are important developmental defects requiring surgical treatment. Although there are defined differences between both lesions, the treatment and follow-up processes are the same. Hydrocephalus has an important place among the complications that may develop after surgical closure of the defect.Purpose Analysis of factors that may determine the need for shunting in the postoperative period in patients with MM and MS defectsMethod A retrospective analysis of 100 patients (60 females and 40 males) who were treated for MM and MS between the years 2013 to 2023 at our institution was conducted. The infants were divided into two groups: Group 1; those who underwent V-P shunt surgery following MM or MS repair surgeries (n = 81) and Group 2; those who did not receive V-P shunt surgery following MM or MS repair (n = 19). Parameters such as head circumference, MM sac integrity, MM sac size, MM sac location, and birth weight were examined. The results were analyzed to identify any potential differences between the two groups.Results We included 100 patients with myelomeningocele (MM, n = 86) or myeloschisis (MS, n = 14) abnormalies in this study. The rate of V-P shunt insertion was significantly higher in infants with preoperative hydrocephalus, those with an open myelomeningocele sac structure and those with abnormalies in the thoracic/thoracolumbar region.Conclusion In infants born with myelomeningocele or myeloschisis, determining the development of hydrocephalus and the need for V-P shunt placement after the repair of the defect is crucial. This evaluation helps in planning the management of these patients, aiming to minimize complications and to improve the overall prognosis.
Cerebral consumption of lactate contributes to neurological injury after experimental cardiac arrest in rabbits
Authors: Faucher Estelle , Demelos Alexandra , Boissady Emilie , Abi-Zeid-Daou Yara , Lidouren Fanny , Vigué Bernard , Rodrigues Aurore , Ghaleh Bijan , Tissier Renaud , Kohlhauer Matthias
Published: February 2024

Background: During focal ischemia, neurons can use lactate as an alternative source of energy through its oxidation into pyruvate by the lactate dehydrogenase (LDH). After cardiac arrest, the neurological consequences of this phenomenon are unknown.
Methods: Rabbits were surgically instrumented and submitted to 10 min of ventricular fibrillation. After cardiopulmonary resuscitation, they were followed during 4 hours for the evaluation of the cerebral consumption and concentrations of several metabolites (n=6 / group) or during 48 hours for the evaluation of the neurological outcome (n=7 per group). In a first protocol, rabbits received either lactate, pyruvate or vehicle. In a second protocol, they received oxamate (LDH inhibitor), fluorocitrate (inhibitor of tricarboxylic acid cycle) or vehicle (Oxa, FC and Control groups). Finally, in a third protocol, they were submitted to rapid hypothermia induced by total liquid ventilation as an established neuroprotective approach, as compared to normothermia (TLV and Control groups).
Results: In the first protocol, lactate and pyruvate administration enhanced metabolic disorders and cerebral consumption of lactate after cardiac arrest. This was associated with increased neurological dysfunction (median score = 72% [64 – 100], 100% [80 – 100] and 53% [38 – 60] in Lactate, Pyruvate and Control group respectively) at 48 hours after cardiac arrest. In the second protocol, oxamate and FC inhibited lactate metabolism vs Control and subsequently improved neurological recovery (median score = 15% [0 – 45], 16% [0 – 55] and 62% [38 – 72],for Oxa, FC and Control groups, respectively). In the third protocol, rapid hypothermia by TLV both mitigated lactate metabolism and and improved the neurological recovery.
Conclusions: After cardiac arrest, cerebral oxidation of lactate into pyruvate by the neurons is deleterious. LDH inhibition might represent a promising therapeutic strategy for neuroprotection in this setting.
Analyzing the Structural Integrity and Efficiency of Silos: A Comparative Study of Plate Thickness Variations
Authors: Harle Shrikant M. , Bhagat Amol
Published: February 2024

This study investigates the influence of plate thickness on stress distribution within silo structures through a comparative analysis across various models. The analysis, conducted using STAAD-PRO software, explores stress components such as Principal top stress, Tresca top stress, membrane stress (SX), and shear stresses (SQX and SQY). Results demonstrate a consistent trend: as plate thickness increases from 0.1 meters to 0.5 meters, stress levels decrease across all components. Thicker plates exhibit enhanced structural robustness, reducing stress concentrations and improving overall stability. Additionally, maximum stress occurs at the top portions of the silo structure for thinner plates, while stress variations exist among different stress components across models. These findings emphasize the critical role of plate thickness in optimizing silo design for enhanced structural integrity and operational reliability. Understanding stress distributions is essential for informed decision-making in silo construction, ensuring safety and performance under operational conditions.
Primary large B-cell lymphoma of the adrenal gland has similar clinical, pathological, and genetic features to the primary large B-cell lymphoma of immune-privileged sites
Authors: Wang Chaofu , Deng Shijie , Li Anqi , Wang Zhongyu , Wang Xuejing , Ouyang Binshen , Zhu Lingyan , Yu Teng , Jiang Li , Fan Yue , Zhang Yuxiu , Shen Xia , Xu Hai-Min , Ruan Miao , Da Qian , Wang Jing , Dong Lei , Liu Zebing , Yi Hongmei
Published: February 2024

Primary large B-cell lymphoma of immune-privileged sites (IP-LBCL) is a newly categorized disease entity in the 5th WHO Classification of Tumors. Through the analysis of 47 primary adrenal large B-cell lymphoma (PA-LBCL) cases, we unraveled the similarity to IP-LBCL in clinical presentation, pathological features, and genetic landscape. Our findings reveal a predominant immunophenotype of Bcl6 + CD10-Mum1 + in PA-LBCL, mirroring that observed in IP-LBCL, and a shared mutation spectrum characterized by the notable presence of PIM1, MYD88 L265P and CD79B mutations. Moreover, PA-LBCL emerges as a unique subset within the lymphoma spectrum, exhibiting a more favorable prognosis than DLBCL-NOS with secondary adrenal involvement, a revelation that challenges existing paradigms. The study not only calls for a reevaluation of PA-LBCL’s classification within the realm of large B-cell lymphomas but also opens new avenues for targeted therapeutic strategies and prognostic assessment. This research improves our understanding of lymphomas, particularly those arising in atypical locations, reshaping the landscape of lymphoma classification and management.
Elucidating the Role of Metabolic and Cardiovascular Risk Factors in Benign Adrenal Tumors
Authors: Chen Junhao , Li Xiangyun , Zuo Jieming , Dong Haonan , Shi Hongjin , Deng Cheng , Wang Haifeng , Fu Shi , Li Hongqiong
Published: February 2024

Objective: Cardiovascular and metabolic diseases, including both obesity and blood pressure, have been previously implicated in observational studies as having some association with the occurrence of adrenal tumors. This study aims to evaluate the causal relationships of these high-risk factors with the disease using a Mendelian randomization approach with two-sample data. Single nucleotide polymorphisms (SNPs) for blood pressure, BMI, blood glucose, and cardiovascular diseases were extracted from publicly available whole-genome databases. These were then compared separately with benign adrenal tumors. It was found that only BMI was associated with the occurrence of benign adrenal tumors, and this process may be mediated by C-reactive protein (CRP). We explore whether C-reactive protein (CRP) can mediate the causal relationship between body mass index (BMI) and benign adrenal tumors, further investigating the mechanism and the proportion of CRP involved in this process.
Methods: Utilizing a two-sample Mendelian randomization approach, comparisons were made between BMI, blood pressure, cardiovascular diseases, blood glucose, and the outcome. Subsequently, both two-sample Mendelian randomization and multivariable Mendelian randomization (MVMR) analyses were conducted to investigate whether CRP serves as a mediator in the causal relationship between BMI and benign adrenal tumors, while calculating the proportion of mediation involved.
Results: There was no causal relationship observed between blood pressure (OR=0.976, 95%CI=0.931-1.024, p=0.339), blood glucose (OR=0.960, 95%CI=0.648-1.422, p=0.840), cardiovascular diseases (OR=0.724, 95%CI=0.244-2.142, p=0.559), and benign adrenal tumors. However, a positive causal relationship was found between BMI and benign adrenal tumors (OR=1.20, 95%CI=1.06-1.35, p=0.003). There was also a positive causal relationship observed between BMI and CRP (OR=1.07, 95%CI=1.06-1.08, p<0.01), as well as between CRP and benign adrenal tumors (OR=1.401, 95%CI=1.017-1.929, p=0.038). After adjusting for CRP, the causal relationship between BMI and benign adrenal tumors diminished (OR=1.35, 95%CI=1.06-1.73, p=0.014). Even after controlling for BMI, a causal relationship between CRP and benign adrenal tumors persisted (OR=1.32, 95%CI=1.03-1.69, p=0.025). The proportion of mediation by CRP was calculated to be 10.4%.
Conclusion: Using Mendelian genetic research methods, this study provides evidence that elevated levels of C-reactive protein may serve as a crucial mediating factor in BMI-induced benign adrenal tumors. Therefore, clinicians should pay particular attention to monitoring and managing levels of C-reactive protein when dealing with obese patients, to more effectively prevent the development of adrenal tumors.
Integration of Multi-omics Data Revealed the Orphan CpG Islands and Enhancer-dominated Cis-regulatory Network in Glioma
Authors: yao jiawei , Yao Penglei , Li Yang , he ke , ma xinqi , Yang Qingsong , Jia Junming , Chen Zeren , Gu Shuqing , Li Weihua , Wang Guangzhi , Guo Mian
Published: February 2024

Background: The complex transcriptional regulatory network leads to the poor prognosis of glioma. The role of orphan CpG islands (oCGIs) in the transcriptional regulatory network has been overlooked. Establishing a sophisticated transcriptional regulatory system is paramount.Methods: We constructed different cis-regulatory models through mutual information and Bayesian networks. We utilized eleven machine learning algorithms to develop classifiers that could effectively integrate multi-omics datasets. we utilized single-cell multi-omics data construct a higher-resolution cis-regulatory network. To investigate the binding interaction between oCGIs and transcription factors, we utilized chromatin immunoprecipitation assay and qRT-PCR. Furthermore, we assessed the proliferative status of various glioma subtypes using the MTT assay and immunohistochemistry.Results: The cis-regulatory network dominated by oCGIs and enhancers was significantly active in the glioma subtypes, mainly characterized by glioblastoma (Cluster 2). Direct regulation of target genes by oCGIs or enhancers is of great importance in the cis-regulatory network. Furthermore, based on single-cell multi-omics data, we found that the highly activated cis-regulatory network in Cluster 2 sustains the high proliferative potential of glioma cells. The upregulation of oCGIs and enhancers related genes in Cluster 2 results in glioma patients exhibiting resistance to radiotherapy and chemotherapy. These findings were further validated through glioma cell line related experiments.Conclusion: Our study systematically elucidated the cis-regulatory role of oCGIs for the first time. The comprehensive characterization of the multi-omics features of the oCGIs- and enhancers-dominated cis-regulatory network offers a novel insight into the pathogenesis of glioma and provides new strategies to treat this challenging disease.
Range expansion risk for a newly established invasive duckweed species in Europe and Canada
Authors: Andrade-Pereira Debora , Cuddington Kim
Published: February 2024

Landoltia punctata is an invasive aquatic plant that has spread across the United States. Unlike native duckweeds, this species has developed herbicide resistance. As a result, invasion can lead to high management costs and the loss of recreational areas and natural habitats. The species has been recently found in Europe, and is also approaching the northern US border with Canada. We predicted the potential distribution of L. punctata in western Europe and Canada using presence-only data from the Global Biodiversity Information Facility as well as other literature records. We fit predictive models to this data using a Maxent approach. Since climate data based on surface lake water conditions are often more relevant to macrophytes than air temperature metrics, our models included both water and air temperature bioclimatic variables related to the life history of the species. Model comparisons confirmed a superior fit of lake temperatures to duckweed distribution records. The best fit model suggests a high habitat suitability for the species in most Western European countries and Western Canada. A moderate emission scenario suggests that in 2070 currently compatible areas will still be suitable, and that the Great Lakes region will become suitable. Preventive measures to avoid future spread of L. punctata are recommended in these locations to avoid impacts associated with this and similar duckweed species in Europe and the US.
The prevalence of allergic diseases is associated with clinical outcomes in ulcerative colitis
Authors: Yamamoto Yasunori , Furukawa Shinya , Yoshida Osamu , Miyake Teruki , Shiraishi Kana , Hashimoto Yu , Tange Kazuhiro , Kitahata Shogo , Ninomiya Tomoyuki , Yagi Sen , Masakazu Hanayama , Suzuki Seiyuu , Shibata Naozumi , Murakami Hidehiro , Ohashi Katsuhisa , Tomida Hideomi , Takeshita Eiji , Ikeda Yoshio , Hiasa Yoichi
Published: February 2024

Background: No evidence regarding the association between the prevalence of allergic diseases and the clinical activity of ulcerative colitis (UC) exists, although several studies have shown the positive association between allergic diseases and onset of UC. Aim: This study aimed to investigate this issue in patients with UC.
Methods: We studied 289 Japanese patients with UC. Information regarding allergic diseases (asthma, atopic dermatitis, pollen allergy, food allergy, and drug allergy) diagnosed by a medical doctor, lifestyle, and medical history were collected using a self-administered questionnaire. The definition of mucosal healing (MH) was Mayo Endoscopic Score 0. The association between each allergic disease and its multimorbidity with MH was evaluated using multivariate logistic regression analyses.
Results: Pollen allergy was the most common allergic disease (36.3%). Pollen allergy and food allergy were independently positively associated with MH (pollen allergy adjusted odds ratio (OR): 1.82 [95% confidence interval (CI): 1.01–3.26]; food allergy adjusted OR: 3.47 [95% CI: 1.26–9.68]). The rate of MH for 0, 1, 2, and 3 or more allergic diseases was 22.6%, 21.3%, 29.7%, and 59.3%, respectively. After adjustment, 3 or more allergic diseases was independently and positively associated with MH (adjusted OR for 3 or more diseases: 8.13 [95% CI: 2.17–34.04], p for trend = 0.020).
Conclusions.: In patients with UC, pollen allergy and food allergy were independently positively associated with MH, respectively. Additionally, allergic multimorbidity was independently positively associated with MH.
Solving Integer Linear plus Linear Fractional Programs
Authors: CHERFAOUI Yasmine , FALI Fatima , Abid Saber
Published: February 2024

The optimization of integer linear plus linear fractional programs (ILLFPs) presents significant challenges in the research field. This study introduces two innovative methods designed to efficiently address the non-convex and non-linear characteristics of ILLFPs. The first method proposed is an implicit exploration or branch and cut approach, which systematically explores the problem domain until the optimal solution is attained. The second method is a parametric approach that employs a linear integer program, adjusting parameter values until the solution matches the optimal solution of the ILLFP. Computational experiments were conducted using randomly generated instances to evaluate the effectiveness of these methods. The results indicate that the parametric approach outperforms the branch and cut method.
The Potential of Vehicle-to-Home Integration for Residential Prosumers: A Case Study
Authors: Brennenstuhl Marcus , Otto Robert , Elangowan Pawan , Eicker Ursula
Published: February 2024

The transition of the transport sector to e-mobility poses various challenges, but also provides great flexible load and supply potential and thus enables a stronger coupling of the transport sector with other sectors. If emerging opportunities such as bidirectional charging in the context of Vehicle-to-Home and Vehicle-to-Grid applications are utilised, a previously unimagined load management and storage potential can be tapped. This can transform e-mobility from an additional burden to the grid to a grid-supporting factor that enables greater integration of renewable energies and reduces additional investments in infrastructure like grid expansion and stationary storage systems. In order to investigate this potential, within this work we examine simulation based various Vehicle-to-Home (PV self-consumption, load shifting due to flexible electricity tariff) and Vehicle-to-Grid (secondary reserve) scenarios for different driving profiles for a residential building with heat pump, PV system and optionally with small wind turbine. In addition, a charge load optimisation is carried out using a genetic algorithm. The energy quantities, saving potential and the additional number of battery cycles are quantified. The results show that, despite additional battery degradation, significant financial incentives can be achieved.
Integration der Maker Education in die Lehramtsausbildung – das Digitallabor der Universität Osnabrück
Authors: Stolzenburg Alina , Beste Alexander , Piwowar Alexander , Schurz Katharina , Thelen Tobias
Published: February 2024

Der folgende Beitrag stellt das Konzept eines universitätsweiten Digitallabors der Universität Osnabrück vor, das in seinem Aufbau an Makerspaces und Fablabs angelehnt ist, insbesondere Lehramtsstudierende bei der Entwicklung von Digitalkompetenz fördert und Impulse für die Verwirklichung innovativer Lehr- und Lernsettings liefert. Es handelt sich um einen offenen Lernort mit mehreren Räumen für selbstorganisiertes Lernen, z. B. einem Maschinenpark sowie Podcast- und Videostudios. Da in Bezug auf Kompetenzentwicklungsmodelle, die die Anbahnung von Digitalkompetenz bei angehenden Lehrer:innen modellieren, eine Forschungslücke besteht, werden derzeit auf Basis von DigComp und DigCompEdu curriculare und extracurriculare Angebote im Digitallabor konzipiert, die der Zielgruppe den intrinsisch motivierten Zugang und das Entwickeln eines sich durch Digitalkompetenz auszeichnenden Profils ermöglichen sollen. Parallel zum Lernen vor Ort vermitteln praxisvorbereitende extracurriculare Online-Selbstlernmodule grundlegendes Technikwissen, wie am Beispiel des 3D-Drucks gezeigt wird. Der curriculare Ansatz basiert auf einem didaktischen Methodenmix inkl. eines E-Portfolios. Die Lernbegleiter:innen schaffen in Anlehnung an das Cognitive Apprenticeship-Modell einen geeigneten Rahmen, um authentische Probleme mit Lebensweltbezug im Sinne situierten Lernens abzubilden und intrinsische Motivation zu erzeugen. Ziel des Digitallabors ist es, so die Anbahnung von Digitalkompetenz in die Erfahrungswelt der Lernenden zu implementieren und Transferprozesse für spätere Herausforderungen anzustossen.
Reabilitação Oral de Paciente Classe III de Angle com Prótese Total Superior Relato de Caso
Authors: Torres José Lucas Medeiros , Torres Kátia Mayane Balduino , Silva Nelmara Sousa e , Siqueira Dayane de Souza , Bezerra Diogo Andrade , Andrade Jamesson de Macedo , Sousa João Nilton Lopes de , Sena Luana Samara Balduino de
Published: February 2024

Introdução: Os procedimentos de reabilitação oral com próteses totais contribuem para a melhoria da saúde física e emocional dos pacientes edêntulos, devolvendo função mastigatória, estética, fonética, satisfação e, acima de tudo, qualidade de vida. Objetivo: O presente trabalho teve como objetivo relatar um caso clínico de reabilitação oral em paciente com discrepância dentária ântero-posterior (classe III de Angle) com prótese total. Relato de caso: Paciente M. I. S. S., sexo feminino, 52 anos de idade, procurou atendimento odontológico com a finalidade de substituição de prótese total superior. Iniciou-se o procedimento de moldagem anatômica do arco edêntulo superior com o auxílio de moldeiras de estoque para pacientes desdentados totais utilizando como material de moldagem o alginato e obtenção do modelo de estudo. Em seguida, foram realizadas as etapas de moldagem funcional, confecção de moldeira individual e base de prova, para posterior confecção dos planos de orientação e montagem em ASA. Posteriormente foi realizada a seleção da cor dos dentes artificiais baseada nos dentes inferiores. A paciente retornou para que fosse realizada a prova dos dentes e, em seguida foi realizada a acrilização e entrega da prótese. Por fim, foram verificadas as áreas de trauma e realizado ajustes oclusais. Conclusão: A reabilitação oral de pacientes desdentados com prótese total representa uma excelente alternativa, com custos mais baixos, permite o reestabelecimento da função mastigatória, além de devolver estética, conforto e autoestima aos pacientes, e proporcionar melhorias na qualidade de vida.
Значение ПЭТ, совмещенной с КТ, при диффузной В-крупноклеточной лимфоме: история вопроса, эволюция представлений и современные возможности метода (обзор литературы)
Authors: Вовченко Артем Андреевич , Фалалеева Н. А. , Даниленко А. А. , Терехова А. Ю. , Ходжибекова М. М. , Челмаков А. М. , Замотина А. Г. , Дикова А. С. , Ручкова С. В. , Синицына Ю. В. , Ковальская В. Ю. , Перепелицына А. Н. , Балашова А. Н. , Манаенков Д. А. , Иванов С. А.
Published: February 2024

Combined positron emission tomography/computed tomography (PET/CT) is broadly used not only during initial staging of non-Hodgkin lymphomas (NHL) but also during as well as after treatment. Due to an increasing body of accessible data on classical Hodgkin lymphoma revealing high significance of PET/CT, the amount of relevant information on NHL is also growing day by day. At the moment, there is a consensus that PET/CT results can be effectively used in prognostic risk stratification of patients with different NHL variants, including diffuse large B-cell lymphoma (DLBCL). However, a huge volume of information collected by now hinders a full insight because of clinical variability of DLBCL, different time-points and methods of evaluating PET/CT results. The present review focuses on the role of PET/CT in the diagnosis and assessment of response to DLBCL therapy.
Investigation of News about the Success of Individuals with Special Needs in Türkiye’s News Agencies
Authors: Burak Yakup , Girgin İrem
Published: February 2024

Introduction: The media has prepared several news items about individuals with special needs. This news, with a positive perspective, can change people’s attitudes and behaviors toward individuals with special needs in a positive direction. Thus, this study aimed to examine the news published by national news agencies in Türkiye about the success stories of individuals with special needs using the document analysis method to change negative attitudes and mindsets toward individuals with special needs.
Method: The study was carried out using document analysis, one of the qualitative research methods. The three most distinguished national broadcast networks, Anadolu Agency, Demirören News Agency, and İhlas News Agency, were scanned for success stories of individuals with special needs. The news items published between 2010 and 2022 were analyzed with content analysis and then categorized and examined thoroughly. In total, 259 news items from Anadolu Agency, 311 news items from Demirören Agency, and 66 news items from İhlas News Agency were examined. These news items were evaluated under the following headings: news agency, news type, country of publication, gender of the individual, type of special needs, institution supporting the individual with special needs, type of success, and source of inspiration.
Findings: The findings showed that Türkiye’s national news agencies published many news items about the success stories of individuals with special needs. The news items reached were categorized under education, business, art, sports, and social responsibility. As a result of examining the areas, it was found that most news items were prepared in the sports area.
Discussion: It was observed that negative news in the media was found more common and more visible. Therefore, this study aimed to examine success stories of individuals with special needs. The current study showed that news items regarding the success stories of individuals with special needs in the national news agencies were published broadly. The news items investigated in this study indicate that special needs are represented positively in the media and reveal that individuals with special needs have success stories in the fields of education, business, art, sports, and social responsibility. It can be recommended to scan different news agencies or use different keywords in future research.
An approach for assessment of CO2 leakage using mechanistic modelling: CO2 injection in deep saline aquifer of Lithuanian basin in presence of fault and fractures
Authors: Dangi Shankar Lal , Malik Shruti , Makauskas Pijus , Karliute Vilte , Sharma Ravi , Pal Mayur
Published: February 2024

Injecting CO2 into deep saline aquifers is a prominent strategy for carbon capture and storage (CCS) to mitigate greenhouse gas emissions. However, ensuring the long-term integrity of CO2 storage is crucial to prevent leakage and potential environmental hazards. This paper investigates the impact of presence of faults and fracture on CO2 leakage volumes. Particular case of CO2 injection into a deep saline aquifer for carbon capture and storage (CCS) applications is investigated. This paper explores the relationship between fracture permeability and the potential for CO2 leakage.
Milk Fat Globule Membrane Proteins. 8. Fatty Acid-Binding Protein (FABP)
Authors: Elchaninov Vadim
Published: February 2024

This article continues a series of reviews about the structure and functions of milk fat globule membrane (MFGM) proteins in cow’s milk. This installment introduces publications on the biochemistry of fatty acid binding protein (FABP), which is a polypeptide component of MFGM. The article gives a brief history of its discovery, as well as profiles the proteins that bind hydrophobic ligands and describes the methods of FABP identification in MFGM preparations. Other aspects of FABP studies include: isoforms and modern nomenclature; amino acid sequence and reactions to post-translational modification; spatial organization; mechanisms for binding fatty acids to lipids; well-investigated and hypothesized physiological functions; the effect of haplotypes on milk fatty acids, yield, and protein content.
Product promotion by means of influencer marketing in the Chinese perfumery and cosmetics market
Authors:   HSE University, Volodin Arseny A.
Published: February 2024

The paper discusses the development of ways to improve the procedure of selecting the most effective opinion leaders (influencers) for the promotion of perfumery and cosmetic products based on the results of the empirical study of the audience’s subjective perception in the Chinese market. The analysis was carried out on the basis of a formalized online survey of perfumery and cosmetics consumers — 992 out of 1,032 responses from the Chinese audience were included in the final sample of the study and handled by means of the partial least squares structural equation modeling. The study proposes a conceptual model of the impact of the characteristics of an opinion leader and their messages on the effectiveness of influence marketing represented by consumer intentions and formed brand image through the process of transmitting a message to influence consumer opinion. As a result, the features of the promotion of perfumery and cosmetic products in the Chinese market were revealed. It was found that overestimating the attractiveness of an opinion leader and underestimating their subjective perception by the consumer result in a low effectiveness of influence marketing. The analysis of the message transmission process showed that its moderators come to the fore, namely, consumer engagement and their valence to advertising. Yet, the impact significantly depends on the category of an opinion leader (number of subscribers, type, etc.). It was found that the direct influence of the opinion leader on the intentions of consumers is ineffective. The study offers practical recommendations to improve the procedure for selecting the most effective opinion leader in order to promote products taking into account the identified features. The directions for further research are outlined.
Management of digital transformation in the system of higher education: Global practice
Authors:   Financial University under the Government of the Russian Federation, Shelepaeva Albina Kh.
Published: February 2024

The article discusses various approaches to management processes in the era of digital transformation. Digital challenges in the post-pandemic period have updated new qualification requirements for the higher education system. The transition to distance forms of work, which demonstrated inconsistency in providing quality education, revealed the main problems beginning from a weak infrastructure to the lack of optimal ways of educational activity. The higher education system requires transformation to become competitive in the digital environment and be flexible in assimilating technological innovations. The paper presents the analysis of the main directions of digitalization of higher education with the determined priorities. The study is designed on the methods of bibliometric analysis — counting of the number of publications on a given topic, their content and thesaurus analyses. There were used the built-in tools for analyzing the national bibliographic database of scientific citations and closed systems for searching and machine analysis of large texts of the abstract-analytical system Dimensions.ai. The VOSviewer application was used for the content analysis of the terms, and the resources wordstat.ru and google.trends.com were used to calculate the statistics of requests of the key concepts. The results of the analysis identified a variety of transformational decisions that can be made only at the level of strategic management. System transformations may depend on the given external or internal framework regulated by different subjects of the educational process. The directions of development in the field of digital transformation also depend on the external and internal framework. The article proposes the use of the collegial management format which changes the scheme of interaction between the subjects of education.
A nine-parametric family of embedded methods of sixth order
Authors:   St. Petersburg State University, Olemskoy Igor V. , Eremin Alexey S. ,   St. Petersburg State University, Firyulina Oksana S. ,   St. Petersburg State University
Published: February 2024

In the paper an effective explicit Runge—Kutta type method of the sixth order with an embedded error estimator of order four is presented. The method is applied to the systems that can be structurally partitioned into three subsystems. Its computational scheme effectively uses the structural properties. However this leads to much larger systems of order conditions. These nonlinear conditions and the algorithm of finding a solution with nine free parameters are presented. A certain computational scheme is written down and a numerical comparison to Dormand—Prince pairs of orders 5 and 6 is performed.
Automatically obtaining by methods of flow cytometry and cluster analysis simplified leukocyte formula
Authors:   St. Petersburg State University, Orekhov Andrey V. , Shishkin Viktor I. ,   St. Petersburg State University, Kudriavtseva Galina V. ,   St. Petersburg State University, Pavilaynen Galina V. ,   St. Petersburg State University, Shishkin Viiktor V. ,   St. Petersburg State University, Lyudkevich Nikolay S. ,   St. Petersburg State University
Published: February 2024

The leukocyte formula is the percentage of different groups of white blood cells. According to morphological features, three subpopulations can be distinguished among leukocytes: lymphocytes, monocytes and granulocytes. Granulocytes are divided into neutrophilic, eosinophilic, and basophilic cells. Automatic typologization of white blood cells is an unsolved problem, since at present, during cytometric research, the counting of the number of cells in various subpopulations of leukocytes is actually done manually, which in turn causes the subjectivity of the experiment and large values of errors in calculations. To solve this problem, attempts have been made repeatedly to use cluster analysis methods. In computational experiments, it was shown that the use of standard algorithms, such as the agglomerative methods, EM algorithm, DBSCAN, etc., does not allow to obtain the desired results. In recent years, a large number of research papers have been published describing specialized clustering algorithms for detecting and determining populations of white blood cells, some of them have found practical application, but the problems associated with the presence of a large amount of noise and different data density distribution during leukocyte clustering by flow cytometry methods remain relevant. The article considers an approach to constructing a strategy for automatic allocation of the main leukocyte subpopulations using a modified agglomerative centroid clustering method and discusses the results of computational experiments. The results of calculating the proportion of lymphocytes are compared “manually” and automatically using a modified centroid algorithm.
Generating functions of the Cauchy operator of a hamiltonian system
Authors:   St. Petersburg State University, Shmyrov Alexander S. , Shmyrov Vasiliy A. ,   St. Petersburg State University, Shymanchuk Dmitry V. ,   St. Petersburg State University
Published: February 2024

The article is related to the mathematical apparatus for describing the phase trajectories of a hamiltonian system. An approach related to the construction of generating functions for the Cauchy operator is proposed. It is shown that one-parameter families of generating functions satisfy the Hamilton—Jacobi equation or its modifications. Using the example of small oscillations of a mathematical pendulum, it is shown that the description of the Cauchy operator for sufficiently long periods of time requires the use of generating functions of various types. With the help of generating functions, a variational principle similar to the principle of least action is formulated. The efficiency of using generating functions in the development of conservative methods of numerical integration is also noted.
Deep neural network based resource allocation in D2D wireless networks
Authors:   St. Petersburg State University, Sun Qiushi , Zhang Yuyi ,   St. Petersburg State University, Wu Haitao ,   St. Petersburg State University, Petrosian Ovanes L. ,   St. Petersburg State University
Published: February 2024

The increased complexity of future 5G wireless communication networks presents a fundamental issue for optimal resource allocation. This continuous, constrained optimal control problem must be solved in real-time since the power allocation should be consistent with the instantly evolving channel state. This paper emphasizes the application of deep learning to develop solutions for radio resource allocation problems in multiple-input multiple-output systems. We introduce a supervised deep neural network model combined with particle swarm optimization to address the issue using heuristic-generated data. We train the model and evaluate its ability to anticipate resource allocation solutions accurately. The simulation result indicates that the trained DNN-based model can deliver the nearoptimal solution.
Optimal control of the Navier— Stokes system with a space variable in a network-like domain
Authors:   St. Petersburg State University, Zhabko Aleksei P. , Provotorov Vyacheslav V. ,   Voronezh State University, Sergeev Sergey M. ,   Peter the Great St. Petersburg Polytechnic University
Published: February 2024

The research of the problem of optimal control of the Navier—Stokes evolutionary differential system, considered in Sobolev spaces, the elements of which are functions with carriers in an n-dimensional network-like domain, is presented. Such domain consists of a finite number of subdomains, mutually adjacent to certain parts of the surfaces of their boundaries according to the graph type. For functions that are elements of these spaces, the conditions for the existence of traces on the surfaces of the joining are presented and the conditions of adjacency subdomains to which these functions satisfy are described. In applied questions of the analysis of the processes of transport of continuous media, the conditions of adjacency describe the regularities of the flow of fluid through the boundaries of the adjacent domains. The paper presents the results of following main research questions: 1) weak solvability of the initial boundary value problem for the Navier—Stokes system and obtaining the conditions for the existence of a weak solution to this problem; 2) the formation and solution of optimal control problems of various types of Navier—Stokes system. The fundamental approach to the analysis of the weak solvability of the initial boundary value problem is its reduction to the differential-difference problem (semi-digitization of the original system by a time variable) and subsequent use of a priori estimates for weak solutions of the obtained boundary value problems. The obtained a priori estimates are used to prove the theorem of the existence of a weak solution of the original differential system and indicate the way of the actual construction of this solution. A universal approach to solving the problems of optimal distributed and starting control of the Navier—Stokes evolutionary system is presented. The latter essentially expands the possibilities of analyzing non-stationary network-like processes of applied hydrodynamics (for example, processes of transporting various types of liquids through network or main line pipelines) and optimal control of these processes.
Analysis of mathematical and economic problems of a full-cycle enterprise
Authors:   St. Petersburg State University, Ivanov Nikita G.
Published: February 2024

The paper addresses enterprise management systems. Analysis of mathematical-economic management problems in full-cycle enterprises. The enterprise’s activities are divided into 12 blocks and 42 tasks. The task of quasi-optimal distribution of the production plan across conveyor lines for a month is examined in detail. The task is solved using a numerical gradient descent method. Additionally, an algorithm is proposed for determining the price of products on a marketplace platform, given that the supplier aims to earn a certain margin, while the marketplace has a non-trivial system of commissions and bonuses.
Can Orchestration Teaching be improved?
Authors:   Real Conservatorio Superior de Música “Victoria Eugenia” de Granada, Melnikova Anna A.
Published: February 2024

The fundamentals of mastering orchestration are a well-grounded knowledge of the instruments, their mechanics, techniques, and their phenomenology. To succeed in instrumentation and orchestration praxis, students must commonly 1) massively memorize examples of successful orchestration available in treatises on orchestration; 2) analyze as many as possible orchestral scores, and 3) orchestrate excerpts proposed by their instrumentation teachers. We aimed to conduct an exploratory study to detect possible voids in orchestration teaching. For this purpose we recruited 16 participants for this aim. Eight were Music Pedagogy students in their senior academic year, and the other eight were Composition undergraduates. The participants of the Pedagogy group completed one course in instrumentology, while the composers-students had a background of at least one course in instrumentation. Due to the differences in training, Pedagogy students instrumented an excerpt from a song by Ibert, and Composition students orchestrated an excerpt transcribed for piano from “Romeo and Juliet” (overture-fantasia) composed by Tchaikovsky. Also, we asked the participants to write down all their decisions and choice-making during the task to obtain more information for a deeper insight. As a result, we observed that the participants of both groups showed poor performance and low-quality products, except for those who conducted large ensembles. Both groups presented relevant similarities concerning orchestration-related concepts and procedures. Therefore, we can conclude that the general trend of the handbooks on instrumentation and orchestration is to work from a prescriptive model. We attribute the low-quality results of the composers’ group (comparable to non-composers) to the quantity of information to be integrated into the frame of such a model. Rimsky-Korsakov inaugurated the transition to a nomothetic model concerning the tembrotechnonic musical structure. But still, major understanding must be achieved regarding the timbre.
Marc-André Dalbavie’s “Diadèmes”: From the Polyphony of Layers to the “Polyphony of Processes”
Authors:   Tchaikovsky Moscow State Conservatory, Vysotskaya Marianna S.
Published: February 2024

In the spectral and post-spectral music the category of process acquires special significance. Realizing the idea of an internal connection between form and material, processuality is endowed with compositional functions and, being implemented in a continuum of transformations of sound objects — timbre-harmonic and timbre-textural complexes, — determines the dynamics of shaping. The concept of «composing» directed musical processes as a conductor of the idea of transition and transitivity, which is the cornerstone for the aesthetics of spectralism, becomes part of the compositional strategy of Marc-André Dalbavie (b. 1961). In the Russian-language musicological literature, this publication is the first and so far the only reference to the work of one of the leading contemporary European composers. Based on the material “Diadèmes” for viola solo, instrumental ensemble and electronics 633 (1986), the most important components of the author’s method are considered: the principles of continuity of transformations of sound structures, interpolation of timbre-textured blocks and musical “streams”, as well as the principles of sound polarization and “reintegration” a number of “historical” compositional procedures. Particular attention is paid to the author’s concept of “polyphony of processes” as a tool for the multifaceted implementation of the compositional action of the process category, carried out both within the layers of individual musical parameters — harmony, rhythm, timbre — and in the space of their cross interaction.