bluuebunny/crossref_metadata_2025 huggingface dataset:
The module mir156/spl affects bixin biosynthesis pathway in annatto (Bixa orellana L.)
Authors:   , Machado Kleiton Lima de Godoy
Published: June 2022

Annatto [Bixa orellana L. (Bixaceae)] is a woody plant species that can reach up to 6 meters in height, with a fast growth pattern. Annatto produces a main apocaterotenoid namely bixin, a unique natural dye. This compound is highly used in the textile, pharmaceutical and food industries, among others, making annatto an important crop in both ecological and economic aspects. Despite its relevance, there are several gaps for the understanding of its developmental processes. Perhaps one of the most interesting is the role of miR156/SPL module in its physiology. This microRNA is responsible for integrating plant physiology development through modulation of SPL transcription factors that modulate leaf morphology and anatomy, among other characteristics that may be linked to secondary metabolites production. In this particular, the miR156/SPL module regulates the biosynthesis of sesquiterpenes, flavonoids, anthocyanins, and carotenoids in higher plants. In this context, B. orellana is a promising woody species with an expressive secondary metabolism activity. Therefore, we aimed to assess phenotypic changes, plant phenology, hormonal profile, secondary metabolism, expression of developmental-linked genes, and proteome portray in overexpressing miR156 lines of B. orellana plants (OE::156). We observed new patterns in plant architecture and leaf blade features. In addition, higher IAA and ABA levels were found in OE::156 plants compared to non-transformed plants (Nt). Moreover, OE::156 plants have lower bixin content than Nt. Furthermore, CCD4 showed lower expression in contrast to higher CCD1 transcriptional levels. Besides that, the proteome showed ZEP upaccumulation in OE::156 plants, which indicates that carbons are being translocated from bixin to ABA production. Further studies are suggested to understand the role of specific secondary metabolites regulation by miR156/SPL module. Keywords: microRNA. SPL proteins. Plant development. Phase change. Proteomics.
Evaluation of Pharmacological and Clinical Prophylactic Efficacy of Scrofoloso-12 Group of Electrohomoeopathy Medicine in Eye Disorder
Authors:   Scientific Committee Electrohomoeopathy Foundation Mumbai India, Pandey Surendra
Published: June 2022

Eye disorder is the most common issue in today’s era. Hundreds of various eye disorders and eyesight issues exist. Some diseases are incurable, while many others can be treated. The modern system of medicine works incredibly with advanced techniques and formulations relevant to eye disorder but has certain limitations. Electrohomoeopathy is a new system of medicine founded by Dr. Count Cesare Mattei where the plant is the main source of preparation of medicine. In Electrohomoeopathy we study individual and combination plants show the synergistic effect when specific essence is rationally mixed together to form an effective group against the eye disorder. Spagyric medicine is an old form of natural medicine that has been tested, researched, and practiced for decades. In this article, we are going to discuss the pharmacological activity and the effectiveness of the Scrofoloso-12 group of Electrohomoeopathy medicine with the help of the animal model. Subsequently, we are going to evaluate and correlate the efficacy of Scrofoloso-12 group use in various eye disorders during clinical practice. Hence, the present study focuses on the scientific investigation of the effectiveness of the S12 group against Atropine induced corneal, light reflux, and mydriatic effect of rabbit models.
Possible Role of Ppar-Alpha Agonist in Attenuated Cardioprotective Effects of Ischemic Postconditioning in Diabetic Rat Heart
Authors:   Rayat Bahra University, Kharar, Punjab, India, Shivangi Sharma Shivangi
Published: June 2022

Background: It has been accounted for that infarct size reduction and cardioprotective effects of Ischemic Postconditioning (IPOC) have been abrogated in few pathological conditions including diabetes. Peroxisome Proliferator-Activated Receptor-Alpha (PPAR-Alpha) agonist is known to have cardioprotective effect. Therefore, the current examination researched the possible role of PPAR-Alpha Agonist in Attenuated Cardioprotective Effects of Ischemic Postconditioning in Diabetic Rat Heart. Materials and Methods: Rats were injected Alloxan Monohydrate (150/mg/kg/i.p) single dose to produced diabetes. Isolated Langendorff ’s perfused normal and diabetic rat hearts were subjected to global ischemia for 30 min followed by reperfusion for 120 min. Coronary effluent was analyzed for Lactatedehydogenase (LDH) and Creatine Kinase (CK) release to evaluate the extent of cardiac injury. The oxidative stress in heart was evaluated by measuring Thiobarbituric Acid Reactive Substances (TBARS), superoxide dismutase (SOD) generation and reduced form of glutathione. Result: In the current investigation, Ischemia-reperfusion (I/R) induced oxidative stress by increasing TBARS, superoxide anion generation and the decreased form of glutathione in normal and diabetic rat heart. Moreover, I/R induced myocardial injury, was evaluated in terms of increase in, LDH and CK release in coronary effluent, and reduction in coronary flow rate in normal and diabetic rat heart. The diabetic rat heart showed enhanced I/R induced myocardial injury with high extent of oxidative stress as compared with normal rat heart subjected to I/R Six episodes of IPOC afforded cardioprotection against I/R induced myocardial injury in normal rat heart as assessed in terms of improvement of coronary flow rate and decrease of LDH, CK and oxidative stress. On other hand, IPOC mediated myocardial protection against I/R injury was nullified in diabetic rat heart. Fenofibrate (5µM), a selective agonist of PPAR alpha, its administration markedly restored the Cardioprotective potential of IPOC in diabetic rat heart. Conclusion: The current investigation presumed that, the high degree of oxidative stress produced in diabetic rat heart during reperfusion and resulting inactivation of PPAR alpha receptor might be responsible for abolishing the Cardioprotective potential of IPOC against I/R induced myocardial injury
Din ve Mizah
Authors: BEYAZKILINÇ Eminenur
Published: June 2022

Sosyal etkileşimin en esnek araçlarından biri olarak görülen mizah, geçmişten bugüne önemli bir ilgi alanı olagelmiştir. Son yıllarda sosyal medyanın yayılmasıyla hemen her olayın mizah açısından yorumlanması mizaha olan ilginin göstergesi olarak kabul edilebilir. Mizah insana ait olan hemen her şeyi konu edindiği gibi dini temaları da konu edinmektedir. Bu açıdan bakıldığında mizah, mizahi tutum ve dindarlık biçimleri arasındaki ilişkiler Din Psikolojisinin araştırma konusuna girmektedir. Yusuf Emre tarafından doktora çalışması kapsamında hazırlanan “Din ve Mizah” adlı eser, mizah anlayışı ile dinî yaşayışın farklı görüntüleri arasındaki ilişkiyi kuramsal ve uygulamalı olarak araştırmak amacıyla hazırlanmıştır. Kitap, Giriş, Kuramsal Çerçeve, Araştırma ve Yöntem, Bulgular, Tartışma ve Yorum, Sonuç olmak üzere yedi bölümden oluşmaktadır.
Virtual Reality Methods
Authors: Jones Phil , Osborne Tess , Sullivan-Drage Calla , Keen Natasha , Gadsby Eleanor
Published: June 2022

ePDF and ePUB available Open Access under CC-BY-NC-ND licence. Since the mid-2010s, virtual reality (VR) technology has advanced rapidly. This book explores the many opportunities that VR can offer for humanities and social sciences researchers. The book provides a user-friendly, non-technical methods guide to using ready-made VR content and 360° video as well as creating custom materials. It examines the advantages and disadvantages of different approaches to using VR, providing helpful, real-world examples of how researchers have used the technology.
SACUBITRIL / VALSARTAN (ENTRESTO): A REVIEW ON DEVELOPMENT OF ANALYTICAL METHODS AND ITS ASSESSMENT IN PURE, BULK FORMULATION, BIOLOGICAL FLUIDS AND PHARMACEUTICAL PREPARATION
Authors: SINGH CHANDNI K.
Published: June 2022

This Review focuses on the Recent Developments in Analytical Techniques for Estimation of Valsartan and Sacubitril Alone or in combination with other drugs in various Biological media like Human plasma and urine. The main Objective of this Review is to Unify and Interpret widely Scattered information of reported studies on Potential, Reliable and efficient Analytical Methodologies which can Estimate All the Major Components of Antihypertensive drugs. The information and suggested outlined below may facilitate and guide further Needed studies to optimise the use of Analytical Techniques like HPLC (High Performance Liquid Chromatography), HPTLC ( High Performance Thin Layer Chromatography), GC ( Gas Chromatography) etc. for determination of Antihypertensive Analytes in formulation. The presented work is focused on the use of different Analytical Methods for the estimation of Valsartan and Sacubitril in API as well as formulation. From the Reviewed Literature it is obvious that HPLC is a commonly Available method of testing in Pharmaceutical Laboratory.
FORMULATION AND EVALUATION OF CYCLOSPORINE LOADED CUBOSOMES FOR THE MANAGEMENT OF PSORIASIS
Authors: Antim Rathore , Komal Tikariya , Jayanti Mukherjee
Published: June 2022

Cubosomes can be considered as novel lipid-based nanosystems similar to well-known vesicular systems such as liposomes and niosomes. Cubosomes have been widely formulated using certain amphiphilic lipids (e.g. glyceryl monooleate and phytantriol) in the presence of a suitable stabilizer. They can represent a novel drug delivery system which could be loaded with hydrophilic, lipophilic and amphiphilic drug molecules. They are widely used for various drug delivery applications such as oral, ocular, transdermal and chemotherapy drug delivery. In this study, preparation and characterization of cyclosporine loaded cubosomes have done for the management of psoriasis. The preformulation study and formulation of cubosomes was performed. Evaluation parameters of the cubosomes were performed and results were reported.
A DESTRUIÇÃO FLORESTAL E SEUS IMPACTOS NEGATIVOS AO AMBIENTE: NO POVOADO DE NAMAREPO, DISTRITO DE NAMPULA MOCAMBIQUE
Authors: Antonio Gulaço , Julio Luis Jose , De Fatima Sebastião Falume Delfina , Ossumane Bay Lurdes
Published: June 2022

o presente artigo visa em analisar os impactos ambientais provenientes da destruição da floresta no povoado de Namarepo, distrito de Nampula, a pesquisa é do tipo qualitativa com abordagem descritiva dos fenómenos, através da realização da pesquisa do campo, que compreendeu a articulação de várias técnicas como: a observação directa e indirecta, na aquisição de imagens fotográficas e estudos bibliográficos, os resultados revelam a falta de conhecimento científico sobre a importância das florestas e os benefícios ambientais que ela pode dar ao homem, numa relação reciproca entre Homem-Natureza.
The Effects of Education Models on the Improvement of Public Knowledge of Chronic Kidney Disease
Authors: Dwi Ananda Ningrum Vitarani , Yuantari Rahma , Medisa Dian , Nuryana Kurniawan Irwan
Published: June 2022

Introduction: Chronic kidney disease (CKD) is a global health problem with consistently increasing prevalence and incidence, poor prognosis, and high cost. CKD ranks third in funding in Indonesia, reaching IDR 2.3 trillion/year in 2018. Integrated Guidance Post (Posbindu) program affiliated to PHC (Puskesmas) with community cadres has been launched as a community empowerment effort to suppress CKD incidence. This study aimed to strengthen the capacity of Posbindu cadres as the health driving force about CKD to encourage public awareness of CKD risk factors. Method: This quasi-experimental study with one group pretest-posttest design compared four education models for Posbindu cadres in four PHC in Yogyakarta to improve their knowledge of CKD. All education models used the smart module with models 3 and 4 explicitly involving health-worker collaboration. Model 1 used posters, model 2 used leaflets, while model 4 also used posters and leaflets. Knowledge of CKD was assessed through a previously-validated questionnaire with four knowledge domains. Result: All of the 86 cadres were women aged 43.7±8.6 years, mostly with at least high-school education and no risk factors for CKD predisposition. The results showed that model 4 significantly improved knowledge of CKD risk factors, symptoms and examination, and prevention behavior. Meanwhile, improvement in the last domain about CKD treatment was likely affected by model 3. Conclusion: This study confirmed health-worker collaboration’s significance in increasing public knowledge of CKD. Adding various printed education media effectively increased knowledge of CKD, particularly in cadres with higher educational attainment.
The Incidence of Positive Visual Inspection of Acetic Acid in Dr Cipto Mangunkusumo General Hospital Followed by Liquid Based Cytology, HPV testing and Colposcopy: A Cross Sectional Study
Authors: Indarti Junita , Prasetyo Heru , Alda Kristian
Published: June 2022

Introduction : Cervical cancer is most common cancer in women in Asia Oceania and worldwide. VIA(Visual Inspection after Acetic acid) is being used as an alternative in low- and middle-income countries due to the minimal equipment required. Data from recent systematic reviews and multicentre trials show that VIA to be moderately sensitive for precancerous lesions, as compared with Pap testing. This study aim to determine the incidence of positive VIA, LBC, HPV DNA testing and colposcopy findings obtained from positive VIA cases in Dr. Cipto Mangunkusumo General Hospital.Methods: This was a cross-sectional study. Data was collected from cervical cancer screening by VIA examination at Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia in 2017. Age, VIA results were recorded. The results showed abnormal and predictive cancer lesions (acetowhite lesion) were defined as a “positive test.” The positive VIA result followed by LBC, HPV DNA testing, and Colposcopy. Only 25 performed LBC and HPV DNA test, and 30 of the VIA positive were performed Colposcopy. Results: A total of 1.960 subjects were recruited for this study. The mean age of the subjects was 34.5 years, and 908 (46 %) subjects belong to the 30-40 years age group. Negative VIA result were found in 1893 subjects (96,58%) and 67 subjects (3,42%) had positive results. From 25 VIA positive subject whose gone through LBC and HPV test, 9 subjects (36%) had abnormal LBC, 3 subjects (12%) had positive HPV DNA test. From 30 positive VIA whose got colposcopy examination 17 subjects (56,6 %) had abnormal colposcopy.Conclusions: The number of VIA screening participants in RSCM, Jakarta, Indonesia with positive VIA results is low. Further studies regarding the validation of VIA are required to evaluate its diagnostic value.
Existential risk - Danger Extinction Humanity or Reducing permanent of Potential Humanity
Authors: Shoqeir Jawad A.H.
Published: June 2022

Recently humanity witnessed a shift in way of life affecting natural, social, political, and economic resources. As such, the public and/or private sectors provided alternative ways of communication and working from distich leading to a new source of livelihood, especially after the great COVID pandemic challenges. Such new ways of uncontrolled development in a very short period of time would affect negatively human evolution resilience, as there were so-called critical areas of high sensitivity that cannot be returned to their previous state without the human intervention (soil terraces, reforestation, biodiversity). If the ecological environment is endangered or destroyed as a result of human action; then the risk to human life would be enormous. Critical areas also play a major role in preserving soils and ensuring that biodiversity is preserved and supports the food chain. Unsustainable land management, particularly when coupled with droughts, has contributed to higher dust-storm activity, reducing human well-being in drylands and beyond. This is supported by the Presidential Policy Directive-21, referring to critical infrastructure security and resilience. Many people mistake the future for a continuation of trends, meaning that carrying out the process of continuous development will protect the human and human existence on Earth. The question in our time is not whether global climate change exists or not, it does exist, but rather whether the symbiotic relationship between global capitalism and nation-states has the capacity to meet the challenge posed by global climate change, meaning that there must be a connection, communication, and consensus between developed and non-developed countries to find solutions and cooperation in solving the world problems cooperatively.
Aerospace components made by Polymer material.
Authors: Babar Minal , Saxena Priyansh , Thube Nilesh Vilash , S Gokul Raj
Published: June 2022

The aerospace and aviation industry have fasted growing industries on a global scale. Reliable aircraft demands many top rubber components. These rubber components must-have high performance and endurance properties, since they will be exposed to a range of extreme weather conditions, such as excessively hot or cold temperatures, and different types of oils and gases. Rubber products are becoming more famous because of their durability under extreme environmental conditions and cost-effectiveness. The rubber used for aircraft must be of high quality, and this factor is most important in the production of the necessary parts. To study the effect of all compounding ingredients while optimizing compound design and conforming to the various specification requirements and to study the effect of aging, generally, rubber is tested at three different stages viz. Unvulcanised rubber, vulcanized rubber, and finished product.
Missile Materials.
Authors: Sankpal Pranjali Pandurang , Vourganti Varun
Published: June 2022

The development of missile materials is the key to indigenous materials and their components. The selection of materials includes some the properties such as high strength to weight ratio, easy fabrication, good corrosion resistance, reliable quality, and high fracture toughness. The materials used for the airframe and propulsion system are alloys of aluminum, titanium, magnesium, and maraging steel. Non-metallic materials are also used such as carbon-carbon composites and polymer materials. High purity materials like phosphorous, and silicon are also important for material advancements. The paper outlines the needs and challenges of research and its solutions.
Computational Analysis of Contact Stresses In Involute Spur Gears
Authors: N Arjun
Published: June 2022

The present paper investigates computational analysis of the contact stresses involved in an involute gear system using ANSYS simulation software. Gearing is one of the most critical components in mechanical power transmission systems. The computational simulation of contact stresses of two cylinders is carried out to validate the methodology with available analytical method, Hertz contact stress equation, which are originally derived for contact between two cylinders. The simulation of contact problems with ANSYS is carried out with the stiffness relationship between the two contact areas is usually established through a contact element, spring type is placed between the two contacting areas. The results of the two dimensional FEM analyses using ANSYS, a FEM solver software are presented. The results simulated are in agree with the theoretical values calculated using Hertz contact stress equation
A Study on Concepts De-Laval Nozzle using CFD Tool
Authors: Yadav Krishna , Daware Digambar , Akolkar Vedant , Padalwar Pallavi
Published: June 2022

A device that is used to control the characteristics of fluid is known as a nozzle. Its primary function is to increase the fluid's rate of motion. A traditional De-Laval nozzle will have three distinct parts: a throat, a converging section, and a diverging part. This paper will attempt to detail the bulk of the nozzle concepts developed by De Laval. This paper provides a comprehensive analysis of the nozzle's operational philosophy. In addition, theoretical flow analysis is carried out at a number of locations along the length of the nozzle. The dynamic changes in flow parameters such as pressure, temperature, velocity, and density may be seen with the use of computational fluid dynamics (CFD). The use of CFD is also employed in the simulation of shockwaves.
THRUST GENERATION BY ION PROPULSION TECHNOLOGY
Authors: Kaushik Vishal , Katwale Raghav M. , Sakore Dhiraj N.
Published: June 2022

Electric propulsion system proven to be a suitable and efficient alternative for conventional propulsion systems .Ion thrusters is one of the electric propulsion systems. It has very high specific impulse generation (Isp) and consumes very low amount of fuel. Ion thrusters can easily compete with chemical rockets propulsion, even if the thrust produce is very low compares to chemical propulsion. Ion propulsion system can be used for various space missions like orbit station keeping for geostationary satellite, orbit and altitude controlling, multi-goal missions. Ion thrusters are more compatible for deep space missions as they are tested for endurance test where as chemical proportion is highly unsuitable for deep space mission.
Contemporary Kazakh Crafts in the Focus of Ethno-Symbolism: Methodological Aspects
Authors: Naurzbayeva Almira , Ibragimov Aman
Published: June 2022

The issues of studying symbolism and symbol-creativity in the art of contemporary Kazakh crafts have made the methodological potential of Anthony Smith’s ethno-symbolic concept topical. Relying on the scholar's belief that national traditions are based on a set of stable ethno-cultural symbols that ensure their longevity and vitality, contemporary Kazakh craft can be studied in the aspect of national identity. Anthony Smith’s ethno-symbolic discourse allows us to consider objects of national culture in their historical dynamics as a reconstruction of stable symbolic structures that preserve the national identity core. The study raises the conceptual issue of “ethnicity” and “nationality”, as Anthony Smith’s very position is conceptually opposed to the ideas of both constructivists and supporters of primordialism. The scholar believes that the cultural basis of a nation, its current state depends on “previous development”, on cultural traditions, language and ethnic symbols. Thus, the issues of cultural and national identity appear to be correlated in the aspect of tradition and modernity problem. Craft as a cultural phenomenon of one or another nation bears the stamp of ethnogenesis, in which the whole complex of social dynamics, conditioned by the ontological nature of various forms of human community, participates. Pierre Bourdieu’s theory of socio-analysis on the two-structure society, consisting of production practices and “symbolic matrices” involved in sociogenesis, allows us to use its principles as a methodological approach to the study of both traditional crafts and their modern forms in the aspect of issues of cultural identity, the modernization of the past, the revival of traditional experience, etc. The analysis of some trends in contemporary Kazakh craft has shown that the aspiration for identity to a cultural “pattern” is oriented towards established ethno-cultural symbols. Ethno-symbolic discourse makes the semiotic attitude to traditional symbolism topical. It can be said with confidence that the ethno-symbolic approach opens up new opportunities to consider craft and traditional art as factors influencing the formation and preservation of cultural identity. This article was prepared as part of the Ministry of Education and Science of Kazakhstan project AR09259862 “Research of Traditional Crafts of Modern Kazakhstan: State and Search for Preservation”.
The Effect of Asymmetric Information on the Pricing of Equity Issuance
Authors: Shahhosseini Mehrnoush
Published: June 2022

Purpose: This paper examined the adverse selection in the market for seasoned equity issuance.

Methodology: The asymmetric information explained the price reduction at the date of equity issuance. In particular, equity issuance tended to follow credible information releases since companies issued equity when the market was the most informed about the quality of their firms. The paper exploited brokerage mergers as a quasi-natural experiment that increased information asymmetry through their effect on the extent of research coverage by sell-side equity analysts.

Findings: The broker mergers unexpectedly terminated brokers operation, and the level of analyst coverage decreased for the firms previously covered by these analysts. This paper showed that the cumulative abnormal return was positive around the date of equity issuance when asymmetric information increased and more substantial for stocks that lost analyst coverage relative to the stocks that never lost any coverage. Moreover, affected companies by the brokerage mergers issued more equity after the events compared to the control group. This paper showed the causal impact of losing analyst coverage on price at the time of equity issuance.
Mesopotamian reverberations in the genesis account of creation
Authors: Shogunle O. N. , Babawale Solomon Taiwo
Published: June 2022

The influence of Mesopotamia cannot be overemphasized in biblical studies especially as it concerns the study of creation story. This goes a long way to recognize some similarities between the Mesopotamia narratives and the biblical account. Most comparisons had been carried out between the Genesis narration and ancient creation narratives to the flood stories and the purpose is to discover the basis and to affirm the authenticity of biblical narration. This work therefore examines the „reechoing‟ role of the location known as Mesopotamia, and its place in historical narratives of creation stories and associated stories. The paper adopted thehistorical-critical method and textual analysis. The paper concluded that the biblical creation account and associated stories had their origin in the Mesopotamia and among the city-States that inhabited her prior to the emergence of biblical Israel.
Design Base for a Frameless Glass Structure Using Structural PVB Interlayers and Stainless-Steel Fittings
Authors: Stevels Wim , Fildhuth Thiemo , Wüest Thomas , Haller Matthias , Schieber Roman
Published: June 2022

Minimizing metallic primary structures in directly glazed grid shells is key to increasing transparency. Complete renunciation to a substructure results in the glass itself bearing the loads, with thin glass shells, for example, that support loads mainly via membrane forces. A 4.20 m tall, double-curved, frame-less modular glass shell with stainless steel fittings laminated into the thin interstice of two-ply laminated safety glass has been developed and built as a demonstrator to validate the concept. The fittings used to structurally join the glass modules transfer all translation loads and provide a certain rotational stiffness. They are geometrically designed to reduce stress peaks inside the laminate and feature a laminated contact surface at the edge of the glass. For lamination, an interlayer stack was applied comprising exterior layers of structural PVB to bond the fitting with the glass and translucent PVB as interior core layer for aesthetic reasons. The design of this structure initially relied on generic values for designing and finite element modelling of the fitting-interlayer bond, particularly in tensile “pull-out” mode. The present paper undertakes a review of basic interlayer stack data with regards to viscoelastic properties and adhesion, and the engineering hypotheses using recent preliminary fitting test results for various loading schemes (bending, shear, tensile).
MICA (Monitoring Internal Comfort Application):
Authors: Luca Guidi  , Giovanni Inghirami  , Gerardo Masiello  , Daniele Antonucci  , Pasquale Lucia
Published: June 2022

Façades are one of the main elements that affect indoor environmental quality (IEQ) in buildings and building performance. Given the increasing development of sensor technology, the collection of building monitoring data is useful to understand whether the building and in particular the façade system performs as designed. The increasing use of Technical Building Management (TBM) as well as Building Automatic and Control System (BACs) has been demonstrated to be a promising method to decrease the energy consumption and increase the indoor comfort in new and existing buildings. This project aims to develop a tool showing and processing the monitoring data in a BIM environment using an IFC model. The application has been developed thinking about a BIM approach in the building management. Nowadays IFC models are the most used exchange file format in a BIM process. An IFC file can be loaded into a common data environment (CDE) reachable from stakeholders, sharing information and management strategies. The developed tool is a stand-alone application written in C# which is called MICA (Monitoring Internal Comfort Application). MICA can properly display the monitoring data of building sensors, sharing information between different building actors using the IFC format. It is a platform to visualize, manage and identify the IEQ aspects of building based on real monitored data.
Pre- and Post-Failure Experimental Bending Analysis of Glass Elements Coated by Aged Anti-Shatter Safety Films
Authors: Mattei Silvana , Cozzarini Luca , Bedon Chiara
Published: June 2022

The main goal of Anti-Shatter Films (ASFs) applications for structural glass is to create a barrier able to keep together fragments and minimize risk after any impulsive or static load that could lead glass to cracking. The influence of ASF properties on the flexural strength of coated glass elements is thus a relevant topic for safe design purposes, but still little investigated. To this aim, an experimental material investigation is presented in this paper, in order to achieve a good knowledge of common ASFs from a chemical point of view. Moreover, the deterioration of mechanical and adhesion characteristics for ASF samples subjected to different environmental conditions and accelerated ageing is also investigated, so as to simulate the effects of long-term exposure to high humidity (HU) or high temperature (HT). An experimental campaign carried out on 20 small scale ASF-coated glass specimens is finally presented, based on a three-point bending (3PB) test setup. The out-of-plane bending response of unaged or aged samples is performed by taking into account two different displacement-rate levels, to assess their performance and bending capacity under steady-static or impulsive loads. In both cases, the attention is given to the characterization of elastic and post-failure performances. Finally, support for the interpretation of experimental outcomes is derived from a simplified theoretical model of composite beam with partial connection, in order to estimate the shear stiffness of ASF adhesive components in the elastic stage.
How to Exploit the Glass Mass for Damping a Building?
Authors: Engelmann Michael , Wulff Wulf , Lorenz Thomas , Frey Simon , Wernicke Laurenz , Zhang Yangwen , Schauer Thomas , Bleicher Achim
Published: June 2022

The worlds spectacular skylines host tall and slender buildings to create a maximum of office, residential and commercial space on a minimized footprint. These structures need to cope with increasing wind forces at height and are additionally affected by wind-induced vibration due to their lower natural frequencies. The resulting vibrations make users uncomfortable. Therefore, heavy tuned mass dampers are installed in structures and occupy valuable space especially in the costliest top-floors. As an example, Taipei 101’s steel damper is located between the 87th and 91st floor and weights astonishing 660 metric tons. This raises the need for additional reinforcement which increases cost and carbon footprint.Most buildings in expensive metropolises are cladded with remarkable glass facades. Therefore, we asked the question if it was possible to use the existing mass – more specifically the glass mass in a Double‑Skin Facade – to dampen the building’s movement, create a comfortable space for the user, exploit more floor area for the investor and finally to minimize the amount of building material to reduce carbon footprint for society. The idea was realized in a collaborative research effort of TU Berlin, BTU Cottbus-Senftenberg and Josef Gartner GmbH that resulted in a full-scale mock-up of a Double‑Skin Facade. Its outer skin can move laterally on a guide rail system. As the building starts to move, the facade's inner skin remains fixed to the base structure while the outer skin follows the building’s movement in a delayed manner due to its mass inertia. The fixed inner skin and the moveable outer skin are connected by a spring system that is tuned to the first natural frequency of the base structure. During the motion of the facade’s outer skin, the spring system redirects the relative movement and generates a stabilizing force for the base structure in the opposite direction. Additionally, an electrical machine is placed in between to provide an adjustable damping effect for semi-active and passive control. It also serves the purpose of a generator to study the opportunity to harvest energy. The paper shows the structural design options for the novel facade concept in the context of a project review of Double-Skin and Closed-Cavity Facades. The function of a full-scale mock-up, its fabrication and installation are described to show feasibility and ongoing challenges. First test results reveal a close match between theoretical assumptions and the applied testing. This engineering-driven and experimentally validated design opens a new field of architectural options in sustainable facade design which is focused on tuning physical parameters that affect the damping properties of the global structure.
Joint Research Project (in progress): Draft Standard for Determining the Thermal Stress of Glass and Glass-Glass PV Modules (BIPV) in the Construction Industry
Authors: Ensslen Frank , Schwind Gregor , Schneider Jens , Beinert Andreas , Mahfoudi Achour , Lorenz Elke , Herzberg Wiebke , Elstner Michael , Polakova Michaela , Schäfer Steffen , Erban Christof , Röhner Joachim , Sommer Robert
Published: June 2022

For the design of façade and roof glazing, loads due to dead weight, climatic loads (IGU - pressure differences), wind and snow are well investigated and are considered in engineering practice. However, glass constructions are also ex-posed to thermally induced stresses due to direct solar irradiation. The standards and guidelines available so far, both nationally and at the European level, are partly outdated or contain only simplified instructions and specifications for calculating thermally induced stresses of façade and roof glazing. Within the research project, a variety of façade glazing configurations and additionally building-integrated (BIPV) glass-glass photovoltaic modules, for example as a façade cladding rear ventilated, are being investigated by means of numerical simulation and subsequent experimental validation with up-to-date German meteorological data. The purpose of the project is to reduce or prevent the occurrence of thermally induced glass breakage (thermal breakage) through European standardization. In this way, economic damage can be avoided. The present paper provides an insight into the two-years lasting joint research project, including the current status of science and technology, goals, structure and process, and descriptions of work packages. Results, such as the collection of the various influencing factors, meteorological data, and results from numerical simulations, will be presented after the project has finished at the end of September 2022.
Numerical Analysis of TGU Windows Under Blast – GLASS-SHARD Outlook
Authors: Bedon Chiara , Larcher Martin , Bez Alessia , Amadio Claudio
Published: June 2022

The analysis of load-bearing capacity and the determination of blast protection levels for ordinary glass windows and façade components in buildings is known to represent a design and research issue of crucial importance. In the same way, reliable methods to address this issue are mostly based on cost and management expensive experimental investigations on full-size samples. According to the tendency of recent years, this paper presents some of major outcomes of Finite Element (FE) numerical methods and simulations that have been explored in the framework of the GLASS-SHARD research project for glass windows and facades under explosion or soft-body impact. The attention is focused on the analysis of a Triple Glass Unit (TGU), so as to address the blast performance of a rather ordinary glass window for buildings characterized by the presence of multiple laminated glass (LG) layers, on one side, and by the presence of two interposed gas cavities. The TGU blast performance is investigated in terms of load-bearing capacity of single components, with respect to variations in the input blast loads (stand-off distance R, charge W, etc).
Editorial
Authors: Belis Jan , Bos Freek , Louter Christian
Published: June 2022

Welcome at Challenging Glass 8!We gradually emerge from two difficult years of the covid-19 pandemic raging through the world in waves of constantly changing intensities. The associated uncertainties really put the ‘challenging’ into Challenging Glass this time. Still, some of our peers are not able to join us in Ghent, and they will be sorely missed. Nevertheless, we are happy to be able to return this year to the ‘real thing’: a live event which allows the international glass community to finally meet again in person. An excellent opportunity, especially within the UN-declared International Year of Glass 2022. We look forward to reconnect with international colleagues and old friends, but we also want to extend a particularly warm welcome to new and young peers who perhaps have not yet had many opportunities to build their professional network.
Dedicated as we are to the high standards of the Challenging Glass Conferences, we are once again proud to present a very promising programme. No less than five keynote speakers will share their original insights on glass with us: Stéphany Le Rhun on glass and circularity; Julian Jones on glass and bio-based materials; Markus Feldmann on the oncoming Eurocode on the Design of Glass Structures; and finally Robert Capel and Iris Rombouts on their latest glass projects. In addition, over 70 papers will be presented by experts from around the world, showcasing the latest findings in academia, practice and industry. Moreover, a special session on adhesive bonding in glass construction is organised by the European COST Action CertBond CA18120 - Reliable roadmap for certification of bonded primary structures.
All papers have been peer reviewed by our scientific committee and are published Open Access in Volume 8 of the online Challenging Glass Conference Proceedings. A selection of papers has been subjected to a separate double-blind peer-review process and is published in the special Challenging Glass issue of the Glass Structures & Engineering journal (SpringerNature).
Many thanks go to our sponsors, Scientific Committee members, authors and attendees to make it happen. Let’s enjoy together!
Jan Belis, Freek Bos & Christian LouterConference OrganisersJune 2022
Data Storage and Security in Cloud Computing: A Survey
Authors: Sara Dhingra
Published: June 2022

Cloud computing is envisioned as the next generation of IT enterprise design. Cloud computing distributes application software and data bases to massive data centres, where data and service management may not be completely reliable. This creates a slew of new security issues that have yet to be properly addressed. In this article, we primarily focus on features for ensuring data storage security in the cloud, as well as architecture for data storage that is applied by other cloud service providers vendors, and essential points for establishing data storage security.
Video Transcript Summarization in Marathi
Authors: Shivani Patil  , Swati Yadav  , Shreya Shinde  , Darshani Waghmare  , Rutuja Patil  , Prof. S. A. Babar
Published: June 2022

This paper's purpose is a summarization of the video in Regional Languages. During the procedure, we used methodology NLP, LSA, and MoviePy. This paper aims to produce a Short video of long video without missing any point. The technique first short video of any downloaded video. A web application that takes an input of the video and accuracy of the video, then we get this summaries video into text and this text converted into any Regional language. This paper is going to represent an Extraordinary NLP application. This application benefits Students, and teachers by saving time.
The Impact of ICTs on Teaching, Learning and Progressing
Authors: Padamati Anusha Reddy  , Yedavelly Srinivas Reddy
Published: June 2022

Globally, the importance of information and communication technology (ICT) in education is unquestionable. ICT has the potential to be an extremely effective tool for expanding educational opportunities. ICT’s have the potential to increase access to and quality of education by increasing its relevance and relevance. The impact of ICT on the teaching and learning process is critical because it facilitates teaching and learning, creates a conducive learning environment, and assists learners in developing creative thinking and self-confidence. ICT has created new barriers to high-quality education. It has altered numerous facets of people's lives. The purpose of this paper is to discuss the benefits of using information communication technology (ICT) in education, specifically how it can be used to enhance teaching and learning. Effectively integrating ICT into the teaching and learning process is critical for its improvement. It emphasises the advantages and disadvantages of ICT in education.
How to Rank No.1 on Google SERP’s
Authors: Nakul Taneja
Published: June 2022

This document helps you to rank on google search engine result pages by the help of some techniques and tools.
Psychometric Comparisons of Three Depression Measures for Patients With Stroke
Authors: Chiu En-Chi , Chen Yi-Ju , Wu Wen-Chi , Chou Chiung-Xia , Yu Min-Yuan
Published: June 2022

Importance: Psychometric examinations for patients with stroke remain insufficient. The Center for Epidemiologic Studies Depression Scale (CES–D), Beck Depression Inventory–II (BDI–II), and Geriatric Depression Scale (GDS) are promising outcome measures.

Objective: To examine and compare the reliability and validity of three depression measures in a sample of patients with stroke.

Design: Repeated-measures design.

Setting: A hospital in southern Taiwan.

Participants: Fifty-nine outpatients, who completed three depression measures.

Outcomes and Measures: Cronbach’s α and intraclass correlation coefficients (ICCs) were used to examine the internal consistency and test–retest reliability, respectively, of the three measures. An independent-samples t test was conducted to compare two groups of patients with different levels of disability to investigate discriminative validity. Pearson’s rs were calculated among the three measures to examine concurrent validity.

Results: The three measures had good internal consistency (α = .85–.92) and sufficient test–retest reliability (ICC = .84–.91). The minimal detectable change (percentage of minimal detectable change) was 10.6 (63.3%), 13.5 (98.3%), and 5.8 (49.9%) for the CES–D, BDI–II, and GDS, respectively. There was a statistically significant difference between the two groups in CES–D score (p = .032) and no significant differences on the other two measures (p = .095–.187). The correlations among the three measures ranged from .79 to .89.

Conclusion and Relevance: All three depression measures had sound internal consistency, test–retest reliability, and concurrent validity in patients with stroke.

What This Article Adds: Of the three measures, the CES–D had better discriminative validity, and the GDS demonstrated greater reliability and smaller random measurement error in patients with stroke.
Comparison of high-pitch prospective electrocardiogram-gated pulmonary CT angiography with standard CT pulmonary angiography on dual-source CT for detection of subsegmental pulmonary embolism in patients suspected of acute pulmonary embolism
Authors: Thakur Rohini , Singhal Manphool , Aggrawal Ashutosh Nath , Gorsi Ujjwal , Sharma Navneet , Bhalla Ashish , Khandelwal Niranjan
Published: June 2022

Purpose

Objective of this study was to compare high-pitch prospective electrocardiogram (ECG)-gated computed tomography (CT) pulmonary angiography (HP-PECG-gated CTPA) with standard-pitch non-ECG-gated CT pulmonary angiography (SP-NECG-gated CTPA) on 128-slice dual-source CT (DSCT) for the detection of subsegmental pulmonary embolism (SSPE) in patients suspected of acute pulmonary embolism (APE) with radiation and contrast-optimized protocols. Cardiac-related motion artefacts, lung image quality, and quantitative parameter (pulmonary arterial enhancement, radiation exposure, and contrast) volumes were also compared.

Material and methods

This prospective study enrolled 87 patients clinically suspected of APE and randomly distributed to either group by software. Two radiologists blinded to each other interpreted the images for assessment of SSPE, image quality, and quantitative parameters.

Results

SSPE was diagnosed in 15/44 (34.09%) patients in HP-PECG-gated CTPA, in comparison to 8/43 (18.60%) patients in SP-NECG-gated CTPA. Cardiac motion-related artefacts (blurring of bronchovascular structures and double-line artefacts) were statistically significantly less, with p-value < 0.05. Lung image quality was also better, with p-value < 0.001. Effective radiation dose and contrast volume in HP-PECG-gated CTPA were (2.54 ± 0.80 mSv, 45.05 ± 6 ml) versus SP-NECG-gated CTPA (3.17 ± 1.20 mSv, 74.19 ± 7.63 ml) with p-values of 0.007 and 0.001, respectively.

Conclusions

Radiation and contrast volume-optimized HP-PECG-gated CTPA provides reduced cardiac motion related artefacts of pulmonary arteries, which allows enhanced detection of SSPE. It also provides better image quality of lung and parenchyma with lower radiation exposure and less contrast volume.