bluuebunny/crossref_metadata_2025 huggingface dataset:
Ancestral Caddo Ceramic Vessels from the Tom Shumate Site (41RK2), Rusk County, Texas
Authors: Perttula Timothy
Published: July 2018

The subject of this article are the four ancestral Caddo ceramic vessels from the Tom Shumate site (41RK2) in Rusk County. The site is on Dry Creek in the upper Angelina River basin, about 5 km southeast of the town of Mount Enterprise, Texas (Figure 1). The ceramic vessels were found by the landowner after a flood in April 1935 had exposed a burial feature. Later work in 1935 by The University of Texas at Austin, led by A. T. Jackson, recovered no additional burial features; Jackson purchased the vessels from the landowner.
The Caddo Ceramic Vessels from the Cemetery at 41HS74 on Hatley Creek in the Sabine River Basin, Harrison County, Texas
Authors: Perttula Timothy
Published: July 2018

Site 41HS74 is an ancestral Caddo habitation site and cemetery on Hatley Creek, a southwardflowing tributary to the Sabine River, in the East Texas Pineywoods (Figure 1). The site was investigated in 1986 by Heartfield, Price and Greene, Inc. (1988). The re-analysis of the ceramic vessels recovered from nine burial features at the site are the subject of this article. The vessels are curated at the Texas Archeological Research Laboratory at The University of Texas at Austin (TARL).
EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION
Authors: Tikhonova L. Yu. , Sokolova V. V. , Tarasyuk I. A. , Ekimenko A. M. , Cherenkova M. A. , Kudlay D. A.
Published: July 2018

The article describes the safety and efficiency evaluation of chemotherapy regimens containing bedaquiline used in 23 tuberculosis patients with multiple and extensive drug resistance in Amur Region. Treatment with bedaquiline (24 weeks) and other anti-tuberculosis drugs was highly effective based on sputum conversion criteria: sputum microscopy – 86.7% (13/15; 95% CI 62.1-96.3%), culture ‒ 82.6%, (19/23; 95% CI 62.7-93.0%), and cavity healing ‒ 73.9% (17/23; 95% CI 53.6-87.5%), of them patients with previous treatment failure made 43.6% (10/23). The best outcomes were achieved in the patients with new tuberculosis and relapses. A satisfactory safety profile was demonstrated during this trial piloting chemotherapy regimens containing bedaquiline, no cardiac toxicity was registered.
Social media marketing, functional branding strategy and intentional branding
Authors: Fahmi Al-Zyoud Mohammad
Published: July 2018

It has been suggested that social media marketing may be inclined more towards functional branding than intentional branding. The present study empirically examined the relationship between social media marketing strategies, intentional branding and functional branding with a view to determining where social media marketing strategies are more strongly inclined towards intentional than functional branding. Quantitative data were collected from 133 participants from Jordan marketing departments using questionnaires and analyzed using SPSS. The results of the study confirmed the relationship between social media marketing strategies. However, results showed that social media marketing strategies are more strongly inclined towards intentional branding than functional branding suggesting that social media marketing strategies are oriented towards intentional branding. The study recommends examining the idea of intentional branding and its role in controlling the image of the brand among customers.
Importance of evaluation of ovarian function in women with breast cancer when using endocrinotherapy
Authors: Kononenko I. B. , Snegovoi A. V. , Kovalenko E. I. , Manzyuk L. V. , Selchuk V. Yu.
Published: July 2018

The randomized clinical trials showed the effectiveness of the addition of ovarian suppression to tamoxifen or to aromatase inhibitors after adjuvant chemotherapy in women younger or older than 35 years, but with at least one high-risk factor for recurrence.

However, the lack of clear criteria for evaluating the ovarian function after gonadotoxic chemotherapy, especially in women in the perimenopause, significantly complicates the choice of the right tactics for endocrine therapy. Despite proven efficacy of aromatase inhibitors as part of the adjuvant breast cancer therapy in women with preserved ovarian function in SOFT and TEXT trials, this tactic requires a more differentiated approach, according to many experts.

The relative factors (STRAW criteria, age, gonadotoxicity of chemotherapy) for determining the probability of restoration of ovarian function after the chemotherapy were determined using the characteristics of the menstrual cycle in women with hormone-sensitive breast cancer based on the international trials available in the literature. The introduction of these methods for evaluating the ovarian function after chemotherapy in premenopausal women into the clinical guidelines for the adjuvant management of early breast cancer may make the choice of ovarian suppression more appropriate not only from the clinical, but also from the physiological point of view.
The role of gut microbiota in forming a response to immunotherapy of malignant neoplasms: problem state
Authors: Semiglazova T. Yu. , Brish N. A. , Galunova T. Yu. , Bernatskiy A. S. , Semiglazov V. V.
Published: July 2018

The modern concept of symbiotic relationship between the macroorganism and the gut microbiota is practically assured. The microbiota composition is primarily influenced by environmental factors, genetic and immune factors of the host organism. The gut dysbiosis can lead to the dominance of certain types of bacteria that promote the activation of carcinogenesis mechanisms and the development of malignant tumours of the colon due to chronic inflammation or local immunosuppression. The role of the intestinal microbiota in forming a response to the immunotherapy of malignant neoplasms is of great interest to the medical community in the era of immunooncology. Given that the gut microbiota composition is individual for each person, its examination fits nicely into the up-and-coming concept of a personalized medical approach.
Efferent therapy in the first-line drug treatment of metastatic colorectal cancer
Authors: Kotova Z. S. , Semiglazova T. Yu. , Baldueva I. A. , Latipova D. H. , Yurlov D. O. , Semiglazov V. V. , Teletaeva G. M. , Novik A. V. , Semenova A. I. , Protsenko S. A.
Published: July 2018

The aim of this study is to analyse the efficacy of efferent therapy (hemosorption) as part of drug treatment in patients with metastatic colorectal cancer (mCRC) based on the use of standard first-line chemotherapy combined with the bevacizumab biosimilar. The study included 54 patients with histologically verified mCRC who received the first-line FOLFOX + bevacizumab therapy in combination with and without hemosorption. All patients of the FOLFOX + bevacizumab (+) hemosorption group (n = 32) received the hemosorption using Hemophoenix apparatus on Day 4 of the cycle during the first 6 cycles. A total of 182 hemosorption procedures were performed. The control group included 22 patients receiving the FOLFOX + bevacizumab regimen without hemosorption. The bevacizumab biosimilar was introduced in both groups throughout the treatment at standard doses once every 2 weeks. There was no statistically significant difference between the study groups in the main clinical, pathomorphological, molecular genetic characteristics (sex, age, ECOG status, localization of primary tumor, tumor differentiation, RAS, BRAF mutations, microsatellite instability, etc.).

Blood sampling to evaluate the effect of hemosorption on the pharmacokinetics (PK) of bevacizumab biosimilar was performed during the 2nd cycle before (PK1) and after (PK2) hemosorption procedures. The bevacizumab biosimilar concentration in the blood of patients before and after hemosorption showed no statistically significant difference (p = 0,423).

The use of pharmaceutical treatment in the FOLFOX + bevacizumab (+) hemosorption group contributed to the achievement of an objective response (OR) in 62% of patients (p = 0.001). Median progression-free survival (PFS) was 10 ± 0.9 months [95% CI 8.3-11.7] in the FOLFOX + bevacizumab (+) hemosorption group, and 7 ± 0.5 months [95% CI 4.4-11.6] in the FOLFOX + bevacizumab (-) hemosorption group. There was no significant difference in PFS between the groups of patients treated with FOLFOX + bevacizumab regimen with and without hemosorption (p = 0.445).

There were statistically significant differences in the frequency of nausea, diarrhoea and asthenia in the FOLFOX + bevacizumab (+) hemosorption group. The analysis of the dynamics of the quality of life (QoL) level before and after treatment showed that QoL level related to health (p = 0.0001) as well as the emotional (p = 0.0001) and social (p = 0,04) functioning increased in patients receiving the FOLFOX + bevacizumab regimen in combination with hemosorption, 0,039).

Thus, the addition of hemosorption to the first-line drug treatment according to the FOLFOX + bevacizumab regimen does not affect bevacizumab pharmacokinetics, increases the frequency of objective response, reduces toxicity of the therapy and improves the quality of patients’ life indicators.
BCLC-B hepatocellular carcinoma treatment or when should the systemic therapy be started
Authors: Breder V. V. , Pitkevich M. U. , Virshke E. R. , Kostyakova L. A. , Dzhanyan I. A. , Laktionov K. K.
Published: July 2018

Choice of the optimal therapy for BCLC-B hepatocellular carcinoma (HCC) is a significant clinical problem. Transarterial chemoembolisation (TACE) is considered to be the method of choice as this approach is reported to produce a direct effect and to have a significant survival rate. However, TACE is not always applicable and produce a survival benefit due to the clinical heterogeneity of BCLC-B HCC. The article includes different approaches for BCLC-B HCC patients, TACE prediction and refractory criteria as well as the results obtained. The necessity of timely sorafenib systemic therapy in BCLC-B and in advanced HCC after TACE is discussed. Practical application of regorafenib as the second line in HCC systemic treatment is discussed.
Pazopanib as first-line therapy for patients with metastatic kidney cancer
Authors: Alekseev B. Ya. , Shevchuk I. M.
Published: July 2018

Pazopanib (Votrient®) is an oral small-molecule multi-kinase inhibitor that predominantly inhibits vascular endothelial growth factor receptor-1, -2 and -3, platelet-derived growth factor receptor-α and -β and the stem cell factor receptor c-Kit. In preliminary experiments using mouse and rabbit models of angiogenesis, pazopanib inhibited angiogenesis caused by a combined vascular endothelial growth factor and a major fibroblast growth factor. Although the drug was developed as a therapeutic multi-tumour agent, it is currently approved in many countries for the treatment of advanced soft tissue sarcoma and renal cell carcinoma (RCC). In multicentre, randomized trials of the efficacy of pazopanib as a first-line therapy in patients with metastatic RCC, progression-free survival (PFS) was significantly greater in pazopanib recipients than in cytokine recipients and pazopanib was noninferior to sunitinib with respect to time to disease progression. In addition, side effects such as liver dysfunction and hypertension can be usually managed, and pazopanib is likely to be a more preferred cost-effective option and shows better quality-of-life compared to other alternative drugs.
Cancer pain: facets of a problem
Authors: Abuzarova G. R.
Published: July 2018

Fighting against pain is a primary and very difficult task in palliative care case management. What are the best ways we can reduce human suffering? How to achieve effective and safe anaesthesia? What needs to be done to develop a palliative care service in our country? Read up on this in an interview with the Head of the Oncology Palliative Care Center of the Herzen Moscow Oncology Research Institute of the Ministry of Health of the Russian Federation, Guzel Rafailovna Abuzarova, MD.
OvSynch program, its modifications and alternative hormonal programs in cow reproduction
Authors: JAŚKOWSKI JĘDRZEJ M. , HERUDZIŃSKA MAGDALENA , KULUS JAKUB , BRÜSSOW KLAUS-PETER , GEHRKE MAREK
Published: July 2018

The OvSynch program was formulated over 20 years ago (it consists in administering gonadoliberin on the day of starting the procedure, then injecting prostaglandin 7 days after the GnRH initial injection, and administration of GnRH two days after applying PGF2α. The procedure ends in the insemination of a female 16–20 hours after administering the final dose of the hormone) and it is commonly applied in cow reproduction management protocols. It has evolved into numerous modifications which has boosted its effectiveness. They have consisted in replacing GnRH with hCG or pLH, diversifying the time of the final injection of GnRH, which follows the prostaglandin injection, and postponing insemination after the final GnRH dose, as well as changing the dosage of the aforementioned hormones. To expedite the Ovsynch protocol, so-called PreSynch was used, which involved administering two prostaglandin injections with a 14 day interval before applying the initial GnRH dose in protocol OvSynch. The interval between the second prostaglandin injection in the PreSynch program varied (PreSynch-14, PreSynch-12, PreSynch-11, PreSynch-11 and PreSynch). The pregnancy rate can be also improved by introducing GnRH injection before starting the OvSynch program, administered 7, 6 or 4 days before the initial GnRH injection in OvSynch (G7G, G6G, G4G). Higher pregnancy rates, in comparison to the PreSynch-OvSynch program, can be obtained by applying the DoubleOvsynch protocol. In this protocol two OvSynch programs are administered in a 7-day interval. Lately, alternative programs such as DoubleSynch and EstraDoubleSynch have emerged. The DoubleSynch protocol consists in administering PGF2α in day 0, GnRH on the second day, another PGF application on the 9th day, and the second GnRH dose on the 11th day. Artificial insemination is performed in oriented time (TAI). This solution is used in order to achieve a higher percentage of pregnant cows in comparison to the PreSynch+OvSynch protocol. It also enables synchronisation of heat and ovulation, both after the first and the second hormonal treatment of GnRH. In EstraDoubleSynch protocol the second injection of GnRH at the end of the DoubleSynch program is replaced by estradiol benzoate (BE) administration on the 10th day, in order to acquire a higher level of follicle waves synchronisation and ovulation rate. Those programs applied in cow reproduction management can positively influence fertility and boost cow breeding profitability..
Analysis of the stress (RYR1) gene and osteochondrosis in wild boars in Lithuania
Authors: KLIMAS RAMUTIS , KLIMIENĖ ASTA , MICEIKIENĖ ILONA , MORKŪNIENĖ KRISTINA
Published: July 2018

The aim of the experiment was to determine the RYR1 genotype and to analyse the distribution of osteochondrosis (OC) in wild boars from different regions of Lithuania. Hair and bone samples were collected from wild boars of various sexes and ages that had been shot during hunting season. Genomic DNA was extracted from hair roots. The RYR1 gene was analysed with the PCR-RFLP method, using specific primers and restriction enzymes Alw211 and Hin61. Only one C allele (q = 1.00) and CC genotype of the RYR1 gene were identified. Thus 138 genotyped wild boars were stress-resistant with both dominant alleles intact (no mutation). OC was measured by the cut surface of the distal femur and humerus. The prevalence of OC among the 34 wild boars tested was 20.6%. 5 animals (14.7%) had OC lesions in the hind legs and 2 animals (5.9%) had them in the front legs. OC affected leg joints more often in adult females (third-years and older), but this dependence was not significant (p > 0.05)..
Use of magnetic resonance imaging in the diagnosis of a tibial fissure fracture in a four-year-old American Quarter Horse gelding: A clinical case
Authors: SZKLARZ MAGDALENA , JANECZEK MACIEJ , KASPAREK ANJA , WASELAU MARTIN
Published: July 2018

The summary describes a clinical case of a four-year-old American Quarter Horse gelding presented for evaluation of a grade 2-3 (2-3/5) lameness of the right hind limb. The patient underwent a thorough clinical and orthopaedic examination including limb flexion tests and diagnostic anaesthesia. Intra-articular anaesthesia of the stifle joint was impossible because of the uncooperative behaviour of the horse. However, provocation tests and radiographs proved diagnostically inconclusive. Therefore, magnetic resonance imaging of the right stifle was performed, revealing a tibial fissure fracture. The result was diagnostic and surprising, considering the degree and chronic nature of the lameness. Based on the findings of magnetic resonance imaging, the horse underwent surgery by the locking compression technique to restore full limb function. All implants were removed six months after surgery. The gelding returned to training without any signs of lameness..
Occurrence of internal parasites in cattle in various management systems in South-East Poland
Authors: TOMCZUK KRZYSZTOF , SZCZEPANIAK KLAUDIUSZ , DEMKOWSKA-KUTRZEPA MARTA , ROCZEŃ-KARCZMARZ MONIKA , JUNKUSZEW ANDRZEJ , GRUSZECKI TOMASZ , DROZD LESZEK , KARPIŃSKI MIROSŁAW , STUDZIŃSKA MARIA
Published: July 2018

The changes in the cattle farming system in Poland observed in the last two decades and related to its evolution into massive scale, specialized farming may have an influence on the occurrence of parasitoses. The study was aimed at showing differences in the prevalence of internal parasites in cattle depending on the herd size, management system and production type. In the period of October to December in 2016 and 2017, the study covered 46 farms with a livestock density from 2 to 160 animals (over 1 year of age), including 25 farms with a confined management system, 12 farms using pastures occasionally and 7 farms with animals using pastures during the whole season. Out of these farms, 36 were oriented towards dairy cattle and 10 to beef cattle. The analytical methods involved flotation, sedimentation and the Baermann technique. In total, 276 feces samples were analyzed. The analysis involved a representative number of samples from each farm, depending on the herd size: from 100% of the animals in the smallest farms to 10% in the largest ones. In total, eleven different taxa of parasites were identified, and their general prevalence was as follows: Eimeria spp. 24.6%, Buxtonella sulcata 25.7%, Strongyloides papillosus 7.6%, gastrointestinal nematodes (Trichostrongylidae, Chabertia, Oesophagostomum) 35.1%, Nematodirus spp. 4.7%, Bunostomum phlebotomum 7.6%, Trichuris spp. 6.2%, Fasciola hepatica 6.9%, Paramphistomum spp 2.5%, Moniezia spp. 2.9%, Dictyocaulus viviparus 2.5%. The forms of parasites were found in samples coming from all studied herds. Invasions of protozoa (Eimeria, Buxtonella) were most commonly found in dairy cattle, in large herds managed in a free stall barn system and in beef cattle, in large herds managed in a pasture system. These herds were also most frequently infected with gastrointestinal nematodes. The invasions of trematodes, tapeworms and pulmonary nematodes were detected only in cattle using pastures, most commonly in large herds..
SOSIO KULTURAL POLITIK ISLAM KLASIK (Upaya Menafsiri Akar Kemunculan Politik)
Authors: Ihsan Nur
Published: July 2018

Abstract
Politics are the actions or activities concerned with achieving and using power in a country or society. And The politic has effect to change the best of world, in this chance I will be exploration, what is the ideal politic in the Islam. Because we know the politic gives negatif effect all thaught the reality gives us the best of sistym to the development of the country. So I wanna give the theory about reconstruction Islam of politic, after that we will know what is the ideal politic in our country and we also know the Islam of religion gives us the knowledge how to we take the good condition to our world. So we must know what is the Islam and what is the ideal politic of Islam. And than we must khow the culture of politic in the Islam, so we can wise to all.

Abstraksi
Bias perpolitikan terus menggema di area jiwa, hingga wujud politik ini menyentuh batas pada tataran nilai-nilai agama. Akankah politik yang muncul terus menunggangi agama demi kepentingan dunia yang maya? Ataukah agama akan benar-benar menjadi agama yang mampu memberi titik terang terhadap dunia politik, hingga mampu memberi rambu-rambu kenegaraan untuk memberi kemaslahatan rakyatnya. Sebagai seorang cendikia muslim, semestinya menjadi sosok agamawan yang mampu memberi pilihan terhadap fenomena yang berkembang. Selain itu ia juga harus bisa menerima perbedaan yang ada dan meminimalisir karakter ekstrimis yang tidak menyentuh titik humanis, sehingga agama yang sering digaungkan menjadi rahmat di alam semesta raya dapat dirasakan. Artinya, sebuah wajah yang mampu mengayomi semua bentuk fenomena yang terus menggema. Karena agama turun dijadikan sebagai entitas pijakan utama dalam semua ranah permasalahan, baik dalam keluarga, masyarakat dan bahkan sampai bangsa dan negara.
Obstetric and Neonatal Outcomes of Pregnancies with Mild Gestational Hyperglycemia Diagnosed at Gestational Diabetes Mellitus Screening
Authors: Akgol Sedat , Budak Mehmet Sukru
Published: July 2018

Objective: The aim of this study was to evaluate obstetric and neonatal outcomes of pregnancies with mild gestational hyperglycemia diagnosed at gestational diabetes mellitus screening.Study design: Between September 2016 and August 2017, the pregnant women diagnosed as normal glycaemia or mild gestational hyperglycemia according to the results of gestational diabetes mellitus screening with 50 g oral glucose challenge test, and 100 g oral glucose tolerance test were compared [Normal glycaemia: Blood glucose value <140 mg/dL 1 hour after 50 g oral glucose challenge test].Results: The following results were obtained in the normal glycaemia and mild gestational hyperglycemia groups respectively: Mean gestational age at birth, 38.9±1.6 and 39±1.9 weeks; preterm, term, post-term birth rates, 6%, 86.2% 7.8% and 6.8%, 86.4% and 6.8%; cesarean delivery rate, 30.9% and 34.9%; birth weight 3227.9±394.9 and 3241.05±418.5 g; small for gestational age, 4.4% and 2.3%; large for gestational age 4.6% and 7%; without any significant difference between the groups. Five minute APGAR scores were significantly lower in the mild gestational hyperglycemia group compared to the normal glycaemia group.Conclusion: There was no significant increase in adverse pregnancy outcomes such as preterm birth, post-term birth, increased caesarean delivery rate, small for gestational age and large for gestational age, except for a significant decrease in 5 minute APGAR scores in the mild gestational hyperglycemia group compared to the normal glycaemia group in our study.
Supposed concept: rotation – the method of the universe existence
Authors: Velgas Lev Borisovich , Iavolinskaia Liya Lvovna
Published: July 2018

In this concept, authors seek to prove that all planets revolve around their axes because of the impact of their satellites. The rotation of the joint gravitational force is similar for all planets and for the Sun. The Sun and each planet can have several satellites. The joint gravitational force of each pair – the satellite of the planet and the planet itself, the satellite of the Sun and the Sun itself, if the joint force of gravity, moves due to the motion of the satellite in orbit, rotates the planet or the Sun. The article proves that the joint gravity of the Moon and the Earth, which moves around the Earth due to the Moon's rotation around the Earth, rotates the Earth around its axis. And that the joint gravity of the Moon and Earth holds the Moon so that the side of the Moon with a larger mass is located in the direction of Earth. All satellites (there are more than 150 of them) are in the same rigid stable position – depending on their planets. And all the satellite planets in the solar system in rotation around their axes depend on their satellites. The Earth and the Moon in this matter are not original. Researchers provide evidence of the absence of a thermonuclear reaction on stars and the fact that the energy of solar radiation is electrical energy, not thermonuclear. In addition, the existence of dark matter is questioned in the work. The authors also prove that it is necessary to exclude the term "synchronization", which has no right to exist due to the absence of satellites rotation of the planets around their axes.
Comparative legal analysis of agreements to avoid double taxation concluded by the Russian Federation with OECD and UN models within article 2
Authors: Khusainova Anastasia Valeryevna
Published: July 2018

This article is devoted to the analysis of deviations of the Russian Federation's agreements on avoidance of double taxation within the framework of Article 2 with the OECD and UN model conventions. The author comes to the conclusion that many bilateral tax agreements deviate from OECD and UN models, not covering taxes on capital.
O aluno-problema em questão
Authors: Gomes Edson Soares
Published: July 2018

FREITAS, Marcos Cézar. Aluno-problema: forma social, ética e inclusão. São Paulo: Cortez, 2017. e-PUB.
Involvement of Heme Oxygenase-1 in Neuropsychiatric and Neurodegenerative Diseases
Authors: Neis Vivian B. , Rosa Priscila B. , Moretti Morgana , Rodrigues Ana Lucia S.
Published: July 2018

Heme oxygenase (HO) family catalyzes the conversion of heme into free iron, carbon monoxide and
biliverdin. It possesses two well-characterized isoforms: HO-1 and HO-2. Under brain physiological conditions,
the expression of HO-2 is constitutive, abundant and ubiquitous, whereas HO-1 mRNA and protein are restricted
to small populations of neurons and neuroglia. HO-1 is an inducible enzyme that has been shown to participate as
an essential defensive mechanism for neurons exposed to oxidant challenges, being related to antioxidant defenses
in certain neuropathological conditions. Considering that neurodegenerative diseases (Alzheimer’s Disease
(AD), Parkinson’s Disease (PD) and Multiple Sclerosis (MS)) and neuropsychiatric disorders (depression, anxiety,
Bipolar Disorder (BD) and schizophrenia) are associated with increased inflammatory markers, impaired
redox homeostasis and oxidative stress, conditions that may be associated with alterations in HO-levels/activity,
the purpose of this review is to present evidence on the possible role of HO-1 in these Central Nervous System
(CNS) diseases. In addition, the possible therapeutic potential of targeting brain HO-1 is explored in this review.
Computer Aided Design of Non-toxic Antibacterial Peptides
Authors: Rondon-Villarreal Paola , Pinzon-Reyes Efrain
Published: July 2018

Antimicrobial resistance is increasing at an alarming rate and the number of new antibiotics
developed and approved has decreased in the last decades, basically for economic and regulatory obstacles.
Pathogenic bacteria that are resistant to multiple or all available antibiotics are isolated frequently.
Hence, new antibacterial agents are urgently needed and antimicrobial peptides are being considered as
a potential solution to this important threat. These molecules are small host defense proteins that are part
of the immune systems of most living organisms such as plants, bacteria, invertebrates, vertebrates, and
mammals. These peptides are found in those parts of organisms that are exposed to pathogens and they
are active against multiple organisms such as virus, bacteria, and parasites, among others. This review
shows different strategies in the computational design of new antibacterial peptides, the physicochemical
properties that are considered as the most relevant for the antibacterial activity and toxicity, and it
suggests guidelines in order to help in the finding of new non-toxic antibacterial peptides through the
development of computational models.
Potential Future of New Glutamate Agonists and Antagonists Development
Authors: Matosiuk Dariusz
Published: July 2018

Receptors of glutamic acid are known for over 30 years for their action and for about 20 years for
their structure. Presence of at least three classes of ionotropic receptors was confirmed at the beginning of 80’.
Recognition of the sequence and first cloning were done at the beginning of 90’. In 1994 ligand binding site was
recognized at the junction of two subunits S1-S2 in the ligand-binding domain.

Since then, many subtypes of ionotropic and metabotropic glutamate receptors were recognized, together with
their localization and functions.

In the meantime numerous orthosteric ligands, both agonists and antagonists were developed especially for
NMDA ion channels. Their usefulness as drugs was rather low, due to the involvement in the excitatory tract.
More interest was focused on metabotropic receptors, which are GPSR’s and can be modulated both by orthosteric
and allosteric modulators.

It seems like allosterism could be considered as promising future for glutamate receptors and ion channels,
especially when first allosteric negative modulators of the mGluR2 went close into the clinical trial.
Use of Pressurized Air Infusion For Pre Descemet's Endothelial Keratoplasty (PDEK) - The Air Pump Assisted PDEK Technique
Authors: Jacob Soosan
Published: July 2018

Purpose:

To assess the advantages offered by the air pump assisted PDEK technique that utilizes pressurized Anterior Chamber (AC) air infusion.

Methods:

Pressurized air infusion was provided through an anterior chamber maintainer connected to the fluid air exchange system of a posterior vitrectomy machine during surgery.

Results:

Pressurized air infusion within the AC helped perform Descemetorhexis, prevented bleeding during Peripheral Iridectomy (PI) and synechiolysis, prevented oozing of blood from peripheral corneal neovascularization into the AC and thus helped maintain a non-fibrinous AC environment. In addition, it helped in precise graft manipulation, centration, edge unfolding and unwrinkling after it was floated against the stroma as well as faster graft adhesion. It also prevented AC depth fluctuations during intra-cameral maneuvers and prevented intra-operative as well as post-operative graft detachment.

Conclusions:

This technique makes several steps of surgery easier and improves graft adhesion.
ANFIS Controller Design of DFIG under Distorted Grid Voltage Situations
Authors: Komijani Hossein
Published: July 2018

Background:

Modeling and controlling of Doubly Fed Induction Generator (DFIG) are
presented in this paper. The DFIG is considered in the positive synchronous reference framework under
Distorted Grid Voltage Situations (DGVS). The DFIG electromagnetic torque, active and reactive
powers of the instantaneous stator are discussed under the condition of harmonically DGVS.

Methods:

Four alternative control strategies are implemented on DFIG system to enhance the responses
under DGVS. A novel rotor current controller based on adaptive neuro-fuzzy interface system (ANFIS)
is developed. The main, fifth and seventh order harmonic components of rotor current are straightly
adjusted by ANFIS controller without using any sequential component decomposition techniques at six
times the grid frequency. The simulation results of implementing the presented control strategies on a
two megawatt wind turbine driven DFIG system validate the feasibility and the robustness of the control
scheme.

Results:

The results are compared with the compound controller consisting of a proportional integral
(PI) regulator and a harmonic resonant (R) compensator.

Conclusion:

This comparison indicates the notable removal of torque and DFIG power oscillations
either under DGVS.
Paz e Democracia -- De que forma estão relacionadas?
Authors: Caleiro António Bento
Published: July 2018

A paz e a democracia são dois elementos que, pela sua natureza, parecem (dever) estar associados. À partida, os países onde a democracia é o regime político prevalecente deverão ser também aqueles que se caracterizam por um nível superior de paz. No entanto, é também sabido que muitos países democráticos se têm envolvido em conflitos militares, – sendo certo que externos –, e alguns deles, também, têm sido alvo de atentados de natureza terrorista. Coloca-se, assim, a questão: de que forma a paz e a democracia se relacionam? Neste trabalho pretende-se contribuir para a resposta a esta questão, para tal considerando os mais recentes dados sobre indicadores de paz global (http://visionofhumanity.org/indexes/global-peace-index) e de democracia (https://infographics.economist.com/2017/DemocracyIndex/). Os resultados mostram uma correlação, em termos globais, positiva, mas mostram também que esta correlação difere consoante sejam considerados diferentes clusters de países e/ou as diferentes dimensões inerentes ao indicador da paz.
The Sources of Stress amongst Construction Consultants In Workplace Environment
Authors: Janipha Nurul Afida Isnaini , Ismail Faridah
Published: July 2018

Designers in Malaysia are beginning to feel the existence and growing of stress levels at the workplace due to high pressure and competitive working environment. Designer profession is to create inspiring designs that sometimes lead to stress and affect their work performance. Moreover, stress can cause poor planning, lack of communication and interpersonal conflicts. Therefore, the objective of this paper is to identify the causes and effects of workplace stress among designers. Questionnaire survey was distributed among 500 designers. The respondents are from construction consultant companies in Klang Valley.  The response rate of this paper was performed in about 38% of the samples. The outcome of this research shows that they generally enjoyed their work but sometimes feel stressed due to poor planning and job demand, working surrounding and relationships among staff. This indicates that stress leads to bad designs and sometimes gives bad effects on the performance of the designers.
Осцилляции микроволнового магнитопоглощения в кристаллах HgSe с примесью Fe
Authors: Вейнгер А.И. , Кочман И.В. , Окулов В.И. , Андрийчук М.Д. , Паранчич Л.Д.
Published: July 2018

AbstractMagnetoresistance oscillations are considered in the case of microwave-radiation absorption in HgSe samples with a different Fe-impurity concentration. From the simultaneous analysis of the field and temperature dependences of the Shubnikov–de Haas oscillations, the effective mass, the Dingle temperature, and the quantum-limit field corresponding to the Fermi level are obtained. A method for analyzing the spectra with several oscillation frequencies, i.e., the beating effect, is proposed. The results are compared with data obtained by Hall measurements.
О рекомбинационных процессах в пленках CdS-PbS
Authors: Роках А.Г. , Шишкин М.И. , Аткин В.С.
Published: July 2018

AbstractThe transverse and longitudinal photoconductivity, photoluminescence, and cathodoluminescence of sublimated (CdS)_0.9–(PbS)_0.1 films at room temperature and upon cooling are studied. The role of inclusions of the narrow-gap phase in the processes is shown. The films are excited over the entire active surface and pointwise (within one crystallite). The surface recombination rate and the lifetime of majority charge carriers at different generation rates and characters of excitation are estimated. A comparative table of recombination parameters of CdS and CdS–PbS films is presented.
Динамика изменения фотолюминесценции пористого кремния после гамма-облучения
Authors: Елистратова М.А. , Полоскин Д.С. , Горячев Д.Н. , Захарова И.Б. , Сресели О.М.
Published: July 2018

AbstractRadiation stability of the nanoporous silicon under gamma irradiation was investigated. Changes in the properties of porous silicon under gamma irradiation were registered by measurements of photoluminescence spectra and Fourier-transform infrared (FTIR) spectroscopy. Besides the appearance of point defects and their subsequent oxidation, the significant differences were shown to be in the behavior of the porous silicon properties in comparison with that of bulk silicon apparently due to the quantum size nature of nanoporous silicon.
Модуляция заряда германиевых МДП-структур с фторсодержащими диэлектриками
Authors: Шалимова М.Б.
Published: July 2018

AbstractAn insulator layer of ErF_3, YF_3, NdF_3, and TmF_3 was formed in n -type Ge-based MIS (metal–insulator–semiconductor) structures. It is shown that no negative effective charge is observed in these Ge MIS structures, while the degradation of electric characteristics and the rise of density of surface states leads to an increase in the positive charge. The positive charge formed at the Ge–rare-earth-element fluoride interface can compensate the negative charge of dangling bonds on the surface of Ge, which is potentially promising for modulation of the charge magnitude and sign in MIS devices based on Ge.
Энергетическая структура одиночного акцептора Mn в GaAs : Mn
Authors: Димитриев Г.С. , Сапега В.Ф. , Аверкиев Н.С. , Debus J. , Lahderanta E. , Крайнов И.В.
Published: July 2018

AbstractThe energy structure of the Mn acceptor, which is a complex of Mn^2+ ion plus valence band hole, is investigated in the external magnetic field and under presence of an uniaxial stress has been studied. The spin-flip Raman spectra are studied under resonant excitation of exciton bound to the Mn acceptor. The gfactors of the ground F = 1 and the first excited F = 2 states are determined and selection rules for the optical transitions between the acceptor states are described. The value of the random field (stress or electric field) acting on manganese acceptor and the deformation potential for the exchange interaction constant of the Mn^2+ + hole complex are obtained. A theoretical model is developed that takes into account the influence of random internal and uniaxial external stress and magnetic field. The proposed model describes well the lines of spin-flip Raman scattering of Mn acceptor.
Ферстеровский резонансный перенос энергии с участием светлых и темных экситонов в массивах эпитаксиальных квантовых точек CdSe/ZnSe
Authors: Михайлов Т.Н. , Европейцев Е.А. , Беляев К.Г. , Торопов A.A. , Родина A.В. , Головатенко A.A. , Иванов С.В. , Позина Г. , Шубина T.В.
Published: July 2018

AbstractUsing time-resolved photoluminescence (PL) spectroscopy, we establish the presence of the Förster energy transfer mechanism between two arrays of epitaxial CdSe/ZnSe quantum dots (QDs) of different sizes. The mechanism operates through dipole–dipole interaction between ground excitonic states of the smaller QDs and excited states of the larger QDs. The dependence of energy transfer efficiency on the width of barrier separating the QD insets is shown to be in line with the Förster mechanism. The temperature dependence of the PL decay times and PL intensity suggests the involvement of dark excitons in the energy transfer process.
Oscillations of the degree of circular polarization in the optical spin Hall effect
Authors: Schmidt D. , Berger B. , Bayer M. , Schneider C. , Hofling S. , Sedov E. , Kavokin A. , Abmann M.
Published: July 2018

AbstractThe optical spin Hall effect appears when elastically scattered exciton polaritons couple to an effective magnetic field inside of quantum wells in semiconductor microcavities. Theory predicts an oscillation of the pseudospin of the exciton polaritons in time. Here, we present a detailed analysis of momentum space dynamics of the exciton polariton pseudospin. Compared to what is predicted by theory, we find a higher modulation of the temporal oscillations of the pseudospin. We attribute the higher modulation to additional components of the effective magnetic field which have been neglected in the foundational theory of the optical spin Hall effect. Adjusting the model by adding non-linear polariton-polariton interactions, we find a good agreement in between the experimental results and simulations.
Асимптотика ядер интеграла столкновений линейного уравнения Больцмана при больших значениях индекса для потенциала твердых шаров
Authors: Бакалейников Л.А. , Тропп Э.А. , Флегонтова Е.Ю.
Published: July 2018

AbstractWe have identified the asymptotic behavior of the kernels with large indices of integral operators representing the coefficients of expansion in Legendre polynomials of the collision integral of the linear Boltzmann equation for hard-sphere potential. In the case of interacting particles with nonequal absolute values of velocities, the kernels exhibit exponential decay, where the base of the exponent contains the ratio of the lower to higher velocity. In the case of interacting particles with equal absolute values of velocities, the kernels decay according to the power law.
Экспериментальное исследование многолучевого распространения хаотических радиоимпульсов в беспроводном канале
Authors: Кузьмин Л.В. , Гриневич А.В. , Ушаков М.Д.
Published: July 2018

AbstractAn experimental investigation of the multipath propagation of ultrawideband (UWB) microwave chaotic radio pulses in a wireless channel has been carried out. Based on the results of measurements, conditions of receiving chaotic radio pulses upon passage via a multipath channel are established for various signal delay times.
Влияние напряжений на магнитные свойства пленок NiFe-=SUB=-2-=/SUB=-O-=SUB=-4-=/SUB=- и CoFe-=SUB=-2-=/SUB=-O-=SUB=-4-=/SUB=- на сапфире
Authors: Муслимов А.Э. , Буташин А.В. , Каневский В.М.
Published: July 2018

AbstractWe have studied the influence of mechanical stresses on the magnetic properties of nickel ferrite (NiFev) and cobalt ferrite (CoFe_2O_4) films deposited on sapphire substrates with a - and c -oriented step terrace nanostructures. It is established that compressive stresses favor enhancement of the coercive field in thin ferrite films in the strain direction. Films of magnetically soft nickel ferrite with a room-temperature coercive field of 32.5 mT were obtained.
Влияние серебра на структуру и эффекты памяти формы биосовместимых сплавов на основе TiNi
Authors: Марченко Е.С. , Байгонакова Г.А. , Гюнтер В.Э.
Published: July 2018

AbstractWe have studied the influence of silver addition in various concentrations on the structure and shape memory effect of biocompatible TiNiMoFe alloys. All these alloys at room temperature occur in a mixed state ( B 2 + R or B 2 + R + B 19′) with B 2 austenite phase as the main component. It is established that small concentrations of silver (within 0.5 at % Ag) suppress the shape memory effect, while greater additions (1 at % Ag) stimulate the nucleation and growth of martensite crystals. This is accompanied by increasing content of the main B 2 austenite phase and Ag particles in the alloy.
Interacciones durante el baile social: el rol de los procesos de percepción-acción en la producción participativa de sentido
Authors: Marchiano María , Martínez Isabel Cecilia
Published: July 2018

El trabajo propone un estudio de las interacciones en contextos de baile social, en los que las personas coordinan con la música y con otras personas y donde el movimiento es un aspecto intrínseco de la experiencia musical. Los procesos de percepción-acción, construidos sobre las interacciones intersubjetivas que las personas mantienen a lo largo de sus vidas en determinados contextos culturales, integran la producción de sentido de estas experiencias. La actividad multimodal construida entre los participantes permite la comunicación de los sentidos musicales personales y da lugar a la producción participativa de sentido de la música, definida por la incorporación mutua entre las personas. Estos procesos emergen tanto de las interacciones cara a cara como de las dinámicas de grandes grupos de personas en situación de baile social, cuyo comportamiento se asemeja al de un sistema dinámico. El análisis de la experiencia del baile social bajo el paradigma de la enacción y de los procesos de percepción-acción revela que la producción de sentido personal se constituye y modula en el curso de los vínculos intersubjetivos creados en el contexto de interacción.
Pronunciación y expresión. Un estudio preliminar sobre las posibilidades articulatorias de las consonantes del español como recursos musicales expresivos
Authors: Guzmán Mariano Nicolás
Published: July 2018

El estudio de la pronunciación para el canto ha promovido el desarrollo de herramientas teóricas y analíticas que permiten comprender la realización de los sonidos del habla en la ejecución musical. No obstante, a pesar de que este conocimiento promete el desarrollo de una ejecución vocal inteligible, poco se ha indagado acerca de la potencialidad expresiva de los sonidos del habla en música (probablemente porque suelen ser considerados como unidades lingüísticas desprovistas de significado). El lingüista Alarcos Llorach (1950) propone que estos sonidos son capaces de evocar contenidos afectivos y sensoriales cuando sus rasgos articulatorios son asociados con el componente semántico de la palabra que forman (p. ej., la sílaba tam de la palabra tambor recuerda al toque de este instrumento). De acuerdo con esta idea, pronunciación y expresión ya no serían entendidas como elementos autónomos que contribuyen a la ejecución de la música vocal, sino como componentes del discurso musical que se interrelacionan en su interpretación. Con ánimos de explorar esta relación, nos proponemos estudiar las principales posibilidades articulatorias de las consonantes del español (duplicación, prolongación, afinación, aspiración y variación de la constricción) y cómo son empleadas como recursos musicales expresivos en contextos performáticos por cantantes y directores.
Lectura y escritura musical en la etapa infantil. Más allá de las cinco líneas del pentagrama
Authors: Calderon-Garrido Diego , De las Heras Rosa
Published: July 2018

La lectura y escritura musical en la etapa infantil es un tema controvertido sobre el que existen argumentos a favor y en contra. Este artículo reflexiona sobre la necesidad de enseñar al alumnado de dicha etapa a expresar de forma visual el sonido. Para ello se justifica la adaptación de la escritura tradicional, sin ser ésta exclusiva de la etapa infantil, y se plantean varias propuestas para el aula.
Análisis de la variación como rasgos de estabilidad en el tango: Patrones estilísticos en la producción de la música de Aníbal Troilo y Osvaldo Pugliese
Authors: Alimenti Bel Demian , Martínez Isabel Cecilia
Published: July 2018

El análisis musical anotado de las orquestas típicas de tango expone los modos particulares en que -mediante la variación y la instrumentación- se elaboran los rasgos de los patrones rítmico-melódico-expresivos y de su despliegue tonal. En este trabajo se seleccionaron fragmentos instrumentales interpretados por las orquestas de Aníbal Troilo y Osvaldo Pugliese. Se procedió a: (1) escuchar y anotar pasajes de orquesta que presentaban patrones rítmico-melódico-articulatorios; (2) analizar la superficie musical y elaborar gráficos de reducción notacional; (3) aplicar técnicas microanalíticas para describir el componente expresivo témporo-dinámico. Del análisis se desprende que la variación estilística en el tango no es aleatoria, sino que contiene, intrínsecamente, características invariantes. Es decir que hay una manera de variar que es más identitaria de un estilo compositivo que de otro. Se observó en Pugliese y Troilo el predominio de un tratamiento discursivo a nivel global y de uno a nivel local, respectivamente.