bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação dos fatores associados com lesões periapicais persistentes – casos clínicos
Authors: Thiago Geronimo  , Ludmylla Gomes de Lima  , Luciano Madeira  , Flares Baratto Filho
Published: June 2023

O tratamento endodôntico visa à regeneração do tecido periapical, comprometido por inflamação na região apical. Em inúmeros casos esse reparo não é observado em virtude de diversos fatores, desde a correta instrumentação mecânica durante o procedimento endodôntico até a qualidade final da restauração. Objetivo: Avaliar os aspectos clínicos e moleculares envolvidos na resposta do hospedeiro ante as diferentes abordagens terapêuticas pulpares. Material e métodos: Fez-se a proservação clínica e radiográfica de 11 casos de tratamentos endodônticos de pacientes realizados nas dependências da Universidade da Região de Joinville (Univille) e Centro de Odontologia Especializada (COE) Univille, no período de 2018 a 2020, sendo considerados dados quanto à presença de alterações na condição sistêmica, qualidade da restauração e ao grau de evolução da reparação da lesão periapical. Resultados: Com base na metodologia proposta, constatou-se que em 54,50% dos casos ocorreu regressão total da lesão periapical, em 27,30% regressão parcial e em 18,2% dos pacientes atendidos não houve regressão da lesão, com necessidade de nova intervenção. Conclusão: A técnica operatória foi preponderante no resultado de reparação tecidual em relação à condição sistêmica do paciente.
Clinical Characteristics of Kawasaki Disease in Children with Different Age
Groups: A Literature Review and Retrospective Study
Authors: Tan Weiping , Huang Baoying , Liao Shan , Jiang Wei
Published: June 2023

Background and Objective:

Kawasaki disease (KD) is an acute self-limiting systemic vascular disease
commonly observed in children less than 5 years of age. The present study comparatively assesses the clinical
characteristics of children diagnosed with KD in different age groups. Furthermore, a comprehensive literature
review on the clinical features and diagnostic guidelines of KD is performed.

Methods:

This was a retrospective study conducted on the data of KD children admitted to the Sun Yat-Sen Memorial
Hospital, Guangzhou, China, from January 2016 to December 2018. The children were divided into 3
age groups, including children < 1 year of age (group A, n = 66), 1-5 years of age (group B, n = 74), and children
> 5 years of age (group C, n = 14). Complete clinical evaluation, hematological, and cardiovascular assessments
were conducted and compared between the three groups.

Results:

The time of diagnosis, hemoglobin, and neutrophil ratio of children in group A were significantly lower
than the other two groups (p < 0.05), while the platelet count was significantly higher (p < 0.05). The proportion
of incomplete KD (iKD) was the greatest in group A (40.9%), while the proportion of children with increased
coronary Z value and aseptic meningitis was greater than that in group B (p < 0.0167). Group A
showed less patients with KD shock syndrome (KDSS) than the other two groups (p < 0.05). Group B showed
the greatest number of patients with arthralgia compared to the other two groups (p < 0.05). Three groups
showed no significant difference to intravenous immunoglobulin (IVIG) therapy (p > 0.05).

Conclusion:

The younger the age of KD onset, the more atypical the conditions are, with a greater risk of affecting
other systems and a higher incidences of coronary artery disease. An early treatment with glucocorticoids
might be helpful in older children and those with a greater high-risk KD warning score to prevent coronary injury.
Corrigendum to: Searching for the Magic Bullet: Anticancer Platinum Drugs Which
Can Be Accumulated or Activated in the Tumor Tissue
Authors: Galanski Mathea Sophia , Keppler Bernhard K.
Published: June 2023

An article was published in the journal "Anti-Cancer Agents in Medicinal Chemistry", Volume 7, No. 01, 2007, pp: 55-73 [1]. The first author
is requesting an alteration in the name.

Details of a correction are provided here.

The original name published was Markus Galanski. The request is to change the name to Mathea Sophia Galanski.

The original article can be found online at: https://www.eurekaselect.com/article/3359
Oxidative Stress and Dopaminergic Metabolism: A Major PD Pathogenic
Mechanism and Basis of Potential Antioxidant Therapies
Authors: Rasool Aamir , Manzoor Robina , Kaleem Ullah  , Afzal Ramsha , Ul-Haq Asad , Imran Hadia , Kaleem Imdad , Akhtar Tanveer , Farrukh Anum , Hameed Sahir , Bashir Shahid
Published: June 2023

Reactive oxygen species (ROS)-induced oxidative stress triggers the vicious cycle leading
to the degeneration of dopaminergic neurons in the nigra pars compacta. ROS produced during the
metabolism of dopamine is immediately neutralized by the endogenous antioxidant defense system
(EADS) under physiological conditions. Aging decreases the vigilance of EADS and makes the dopaminergic
neurons more vulnerable to oxidative stress. As a result, ROS left over by EADS oxidize the
dopamine-derived catechols and produces a number of reactive dopamine quinones, which are precursors
to endogenous neurotoxins. In addition, ROS causes lipid peroxidation, uncoupling of the electron
transport chain, and DNA damage, which lead to mitochondrial dysfunction, lysosomal dysfunction,
and synaptic dysfunction. The mutations in genes such as DNAJC6, SYNJ1, SH3GL2, LRRK2,
PRKN, and VPS35 caused by ROS have been associated with synaptic dysfunction and the pathogenesis
of Parkinson’s disease (PD). The available drugs that are used against PD can only delay the progression
of the disease, but they produce various side effects. Through their antioxidant activity, flavonoids
can substantiate the EADS of dopaminergic neurons and disrupt the vicious cycle incepted by
oxidative stress. In this review, we show how the oxidative metabolism of dopamine generates ROS
and dopamine-quinones, which then exert unrestrained OS, causing mutations in several genes involved
in the proper functioning of mitochondrion, synapse, and lysosome. Besides, we also present
some examples of approved drugs used for the treatment of PD, therapies in the clinical trial phase,
and an update on the flavonoids that have been tested to boost the EADS of dopaminergic neurons.
5‑ Sulphosalicylic Acid: An Expeditious Organocatalyst for One‑pot
Synthesis of Indenopyrazolones and its Derivatives
Authors: Kushwaha Smriti , Singh Swastika , Baranwal Jyoti , Jyoti Archana
Published: June 2023

An efficient, 5‑Sulphosalicylic acid (5-SSA) catalysed green protocol for the synthesis of
Indenopyrazolones and its derivatives is reported under metal-free conditions in an ethyl lactate
system. The main advantages of this procedure include the use of an organocatalyst, ethyl lactate as
a recyclable promoting media, practical simplicity, high yields, shorter reaction times, atom economy,
and ease of isolation of the product. These results showed that aromatic aldehydes with electron-
withdrawing groups reacted faster than aldehydes with electron-releasing groups as expected.
According to these observations, aromatic aldehydes with electron-withdrawing groups reacted
more quickly than aldehydes with electron-releasing groups.
Does firm size can moderate the effect of dividend pay-out ratio and leverage on stock volatility?
Authors: Darmayanti Ni Putu Gita , Yadnyana I Ketut
Published: June 2023

This study aims to obtain empirical evidence regarding the effect of dividend pay-out ratio and leverage on stock volatility with firm size as a moderating variable. The theory used in this research is signal theory. This study takes a population of manufacturing companies listed on the IDX in 2017-2021. By using purposive sampling method in accordance with the specified criteria, researchers obtained 27 sample companies with 135 observations. The data analysis technique used is Moderated Regression Analysis (MRA). The research results obtained are the dividend pay-out ratio has a negative effect on stock volatility, leverage has no effect on stock volatility, firm size strengthens the negative relationship dividend pay-out ratio on stock volatility, firm size does not moderate the positive relationship of leverage on stock volatility.
Kollaboratív robotok összehasonlító elemzése
Authors: Buri Zsolt
Published: June 2023

Az alábbi tanulmány négy, az iparban elterjedt robotkar összehasonlítását mutatja be olyan szempontból, hogy az egyetemi oktatásba melyik modell adaptálható a legmegfelelőbben. Az összehasonlító esettanulmány a következő gyártók robotkarjait veszi figyelembe: ABB, Kuka, Universal Robots, Techman Robot. Az összehasonlítás kritériumait a fontossági tényező és a tapasztalatok alapján határoztuk meg. Ezután  a kritériumokat az Analitycal Hierarchy Process (AHP) módszer segítségével rangsoroltuk. A négy alternatíva közötti sorrendet a Kesselring módszer segítségével állítottuk fel. A vizsgálat egy kiválasztási módszert mutat be az ipari robotok területén az egyetemi oktatás szemszögéből.
Automated individual decision-making and profiling [on case C-634/21 - SCHUFA (Scoring)]
Authors: Silveira Alessandra
Published: June 2023

Automated decision-making and profiling are finally being considered before the Court of Justice of the European Union (CJEU). Article 22 GDPR states that “the data subject shall have the right not to be subject to a decision based solely on automated processing, including profiling, which produces legal effects concerning him or her or similarly significantly affects him or her” – but its provisions raise many doubts to the legal doctrine – and to the referring court in the SCHUFA case. The problem with this case law lies in the opacity of inferences or predictions resulting from data analysis, particularly by AI systems – inferences whose application to everyday situations determines how each of us, as personal data subjects, are perceived and evaluated by others. The CJEU has the opportunity to assess the existence of legal remedies to challenge operations which result in automated inferences that are not reasonably justified. However, the effectiveness of the application of the GDPR to inferred data faces several obstacles. This has to do with fact that the GDPR was designed for data provided directly by the data subject – and not for data inferred by digital technologies such as AI systems. This is the difficulty behind the Advocate General’s Opinion.
Nutritional and nutraceutical components of four Cantharellus species (Cantharellaceae, Cantharellales) from the Mountain Region, Veracruz, Mexico
Authors: Hernández-Marañón Edgar Josué , Andrade-Torres Antonio , Chen Jie , Núñez-Pastrana Rosalía , Pérez-Moreno Jesús , Hernández-Marañón Anahí , Llarena-Hernández Régulo Carlos
Published: June 2023

Background and Aims: Cantharellus species are traded in agricultural markets of the Mountain Region, Veracruz, Mexico, as an appreciated mushroom. The objective of this study was to analyze nutrients and nutraceutical properties in four Cantharellus species from Veracruz: antioxidant activity, total phenols, flavonoids, ascorbic acid, lycopene, and β-carotene; as well as the nutritional properties: dry matter, total ashes, crude protein, crude fat, crude fiber, moisture, carbohydrates and energy value of four wild edible mushrooms (Cantharellus violaceovinosus, C. veraecrucis, C. roseocanus y Cantharellus sp.). Methods: Basidiomas of Cantharellus spp. were collected in the Mountain Region, Veracruz, Mexico. The ITS and tef-1α regions were amplified and sequenced. Species were identified molecularly based on the BLAST results. Samples were lyophilized and stored at 4 °C in vacuum bags for the preservation of nutraceutical and nutritional compounds. A methanol-water mixture (80:20 v/v) was used to extract the nutraceutical compounds and to analyze them by spectrophotometric techniques. Key results: In general, outstanding values ​​were found in C. violaceovinosus both in crude protein content (8.04 g/100 g-1) and in antioxidant capacity 2.28 mg TE/g extract. For flavonoids, C. roseocanus showed 2.98 mg QE/g extract and 6.23±0.68 mg/g of carotene. In addition, a high energy value was found in C. violaceovinosus (266.53 Kcal/100g) and C. roseocanus (222.73±15.43 Kcal/100 g). The nutritional and nutraceutical content of C. violaceovinosus, C. veraecrucis and C. roseocanus is presented for the first time. Conclusions: The results show these species from nutritional and nutraceutical perspectives. Cantharellus violaceovinosus showed the highest values of the parameters evaluated. The consumption of these species constitutes an alternative source of protein and nutraceutical components that contribute to food security.
Люминесцентная спектроскопия фосфатов, легированных ионами Pr-=SUP=-3+-=/SUP=-, облученных быстрыми электронами и реакторными нейтронами
Authors: Киселев С.А. , Пустоваров В.А. , Трофимова Е.С. , Петрова М.О.
Published: June 2023

This paper reports the spectroscopic properties of phosphates KLuP2O7, Sr9Sc(PO4)7, K3Lu(PO4)2, doped with Pr3+ ions. Photoluminescence (PL) spectra under selective excitation with UV photons, PL excitation spectra, and decay kinetics of pulsed cathodoluminescence are studied. Recordings of luminescence spectra were done with non-irradiated samples and after their irradiation with fast electrons (E = 10 MeV) or fast reactor neutrons. Three typical channels of electronic excitations radiative relaxation have been identified: interconfigurational d−f transitions, intraconfigurational f−f transitions in Pr3+ ions and luminescence associated with defects. After irradiation, significant changes in the luminescence characteristics were observed: a redistribution of the intensity of the intraconfigurational d−f transitions, an increase in the luminescence yield of defects and the manifestation of new emission centers. The formation of radiation-induced defects presumably occurs due to the formation of complexes consisting of phosphorus and oxygen atoms.
Спектроскопия и фотонное эхо на переходе Er-=SUP=-3+-=/SUP=- с малым неоднородным уширением и телекоммуникационной длиной волны в кристалле YPO-=SUB=-4-=/SUB=-
Authors: Герасимов К.И. , Сабиров Т.Н. , Моисеев С.А. , Байбеков Э.И. , Bettinelli M. , Chou M.C. , Yen Y.-C. , Попова М.Н.
Published: June 2023

The results of investigations of Er3+ ions at an optical transition with a telecommunication wavelength (λ~1530 nm) in a YPO4 crystal by using photon echo and high-resolution laser spectroscopy in magnetic fields up to 4 T are presented. The maximum coherence time (T2) was 113 μs in a magnetic field of 4 T when it is oriented along the optical axis c of the crystal. The main sources of decoherence are discussed.
A Web-Based Tool to Report Adverse Drug Reactions by Community Pharmacists in Australia: Usability Testing Study (Preprint)
Authors: Fossouo Tagne Joel , Yakob Reginald Amin , Mcdonald Rachael , Wickramasinghe Nilmini
Published: June 2023

BACKGROUND

Adverse drug reactions (ADRs) are unintended and harmful events associated with medication use. Despite their significance in postmarketing surveillance, quality improvement, and drug safety research, ADRs are vastly underreported. Enhanced digital-based communication of ADR information to regulators and among care providers could significantly improve patient safety.

OBJECTIVE

This paper presents a usability evaluation of the commercially available GuildCare Adverse Event Recording system, a web-based ADR reporting system widely used by community pharmacists (CPs) in Australia.

METHODS

We developed a structured interview protocol encompassing remote observation, think-aloud moderating techniques, and retrospective questioning to gauge the overall user experience, complemented by the System Usability Scale (SUS) assessment. Thematic analysis was used to analyze field notes from the interviews.

RESULTS

A total of 7 CPs participated in the study, who perceived the system to have above-average usability (SUS score of 68.57). Nonetheless, the structured approach to usability testing unveiled specific functional and user interpretation issues, such as unnecessary information, lack of system clarity, and redundant data fields—critical insights not captured by the SUS results. Design elements like drop-down menus, free-text entry, checkboxes, and prefilled or auto-populated data fields were perceived as useful for enhancing system navigation and facilitating ADR reporting.

CONCLUSIONS

The user-centric design of technology solutions, like the one discussed herein, is crucial to meeting CPs’ information needs and ensuring effective ADR reporting. Developers should adopt a structured approach to usability testing during the developmental phase to address identified issues comprehensively. Such a methodological approach may promote the adoption of ADR reporting systems by CPs and ultimately enhance patient safety.
Evaluation of ChatGPT Dermatology Responses to Common Patient Queries (Preprint)
Authors: Ferreira Alana L , Chu Brian , Grant-Kels Jane M , Ogunleye Temitayo , Lipoff Jules B
Published: June 2023

UNSTRUCTURED

Our evaluation of ChatGPT’s dermatology-related advice revealed a predominance of appropriate responses, as well as areas for improvement and the importance of professional consultations.
User Preferences and Needs for Health Data Collection Using Research Electronic Data Capture: Survey Study (Preprint)
Authors: Soni Hiral , Ivanova Julia , Wilczewski Hattie , Ong Triton , Ross J Nalubega , Bailey Alexandra , Cummins Mollie , Barrera Janelle , Bunnell Brian , Welch Brandon
Published: June 2023

BACKGROUND

Self-administered web-based questionnaires are widely used to collect health data from patients and clinical research participants. REDCap (Research Electronic Data Capture; Vanderbilt University) is a global, secure web application for building and managing electronic data capture. Unfortunately, stakeholder needs and preferences of electronic data collection via REDCap have rarely been studied.

OBJECTIVE

This study aims to survey REDCap researchers and administrators to assess their experience with REDCap, especially their perspectives on the advantages, challenges, and suggestions for the enhancement of REDCap as a data collection tool.

METHODS

We conducted a web-based survey with representatives of REDCap member organizations in the United States. The survey captured information on respondent demographics, quality of patient-reported data collected via REDCap, patient experience of data collection with REDCap, and open-ended questions focusing on the advantages, challenges, and suggestions to enhance REDCap’s data collection experience. Descriptive and inferential analysis measures were used to analyze quantitative data. Thematic analysis was used to analyze open-ended responses focusing on the advantages, disadvantages, and enhancements in data collection experience.

RESULTS

A total of 207 respondents completed the survey. Respondents strongly agreed or agreed that the data collected via REDCap are accurate (188/207, 90.8%), reliable (182/207, 87.9%), and complete (166/207, 80.2%). More than half of respondents strongly agreed or agreed that patients find REDCap easy to use (165/207, 79.7%), could successfully complete tasks without help (151/207, 72.9%), and could do so in a timely manner (163/207, 78.7%). Thematic analysis of open-ended responses yielded 8 major themes: survey development, user experience, survey distribution, survey results, training and support, technology, security, and platform features. The user experience category included more than half of the advantage codes (307/594, 51.7% of codes); meanwhile, respondents reported higher challenges in survey development (169/516, 32.8% of codes), also suggesting the highest enhancement suggestions for the category (162/439, 36.9% of codes).

CONCLUSIONS

Respondents indicated that REDCap is a valued, low-cost, secure resource for clinical research data collection. REDCap’s data collection experience was generally positive among clinical research and care staff members and patients. However, with the advancements in data collection technologies and the availability of modern, intuitive, and mobile-friendly data collection interfaces, there is a critical opportunity to enhance the REDCap experience to meet the needs of researchers and patients.
¿Certeza científica versus intuición humanística? Notas sobre un falso debate
Authors: Guillén Rodríguez Diana
Published: June 2023

Las reflexiones que se desprenden de este artículo parten de la premisa de que no se necesita reproducir los criterios epistémicos y las estrategias metodológicas con los que desde el siglo XIX se valida el rigor científico de las ciencias sociales. Su deslinde del campo de conocimiento humanístico fue promovido por las contribuciones de pensadores como Auguste Comte y Émile Durkheim, quienes dieron vida a un espejismo que parece prolongarse hasta la fecha: si se imita lo que hacen los físicos, los químicos y los biólogos, se puede interpretar con certeza el devenir de la sociedad. Ese espejismo sigue atrayendo a las nuevas generaciones y la influencia de los modelos que en su momento desarrollaron los padres fundadores de la sociología, puede rastrearse, a primera vista, en propuestas novedosas como las de Gary King, Robert Kehoane y Sidney Verba sobre el papel de la inferencia científica en las investigaciones cualitativas. Para analizar los límites y alcances de tales estrategias de producción de conocimiento, recupero tres vertientes del pensamiento crítico: a) la latinoamericana, con las propuestas de Sergio Bagú sobre la relación praxis transformadora/procesos cognitivos y de Hugo Zemelman acerca de los límites del conocimiento que contempla lo dado e ignora lo indeterminado; b) la decolonial en la línea de la epistemología del Sur de Boaventura de Sousa Santos, y c) la microhistoria italiana desde la noción del paradigma indiciario de Carlo Guinzburg.
Evaluación de la actividad antimicrobiana de Bacillus australimaris y Pseudoalteromonas sp. asociadas al octocoral Leptogorgia alba
Authors: Avila-Castro Elizabeth , Vargas-Ponce Ofelia , Díaz-Pérez Leopoldo , Rodríguez-Zaragoza Fabián Alejandro , Hernández-Zulueta Joicye , Aguila-Ramírez Ruth Noemí
Published: June 2023

Los ensamblajes bacterianos asociados a los octocorales les aportan estrategias defensivas mediante la producción de compuestos antimicrobianos para protección frente a los microorganismos patógenos al evitar la colonización por otros microorganismos. Debido a la disminución en el descubrimiento de nuevos compuestos en los entornos terrestres, el potencial de las cepas bacterianas marinas representa una fuente de novedosos compuestos bioactivos. Nuestro objetivo fue evaluar la actividad antimicrobiana de las cepas bacterianas de Bacillus australimaris y las de Pseudoalteromonas sp. aisladas del octocoral Leptogorgia alba de las zonas someras y de las mesofóticas, para conocer el grado de capacidad que tienen para inhibir el crecimiento de los patógenos humanos y de los acuícolas por lo que se realizaron los ensayos cross-streak, difusión en agar por gota, difusión en pozo, difusión en disco, crecimiento sobre celulosa y microplaca de poliestireno. El antagonismo de B. australimaris fue evidente hacia los patógenos de Escherichia coli, Listonella anguillarum, Listeria monocytogenes, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus iniae, y Vibrio campbellii. Por su parte, Pseudoalteromonas sp. impidió el desarrollo de los patógenos E. coli, L. anguillarum, L. monocytogenes, S. iniae, y V. campbellii. Los resultados de este trabajo muestran que las bacterias asociadas a organismos gorgónidos son un recurso biotecnológico potencial en la actividad antimicrobiana.
Percepción de los estudiantes sobre el uso de actividades interactivas con H5P
Authors: Rossetti-López Sergio-Ramón , Coronado-García Manuel-Arturo , Rojas-Rodríguez Isaac-Shamir
Published: June 2023

En el artículo se presentan los resultados de una investigación basada en diseño en la cual se evalúa la percepción de estudiantes universitarios al utilizar objetos de aprendizaje bajo la plataforma H5P. Mediante un estudio de corte cuantitativo, descriptivo, transversal y correlacional, se interviene a una muestra de 208 estudiantes del área económica–administrativa durante los ciclos 2020-1 y 2020-2. Mediante el diseño y aplicación de instrumento del cuestionario, fue posible evaluar desde la perspectiva de los estudiantes las dimensiones de aprendizaje, atención, satisfacción y usabilidad en los objetos de aprendizaje H5P implementados por los docentes como estrategia de enseñanza, cuyos resultados obtenidos mostraron una alta valoración, con excepción de alumnos mercadotecnia, quienes presentaron una percepción baja en relación con los demás programas educativos.
Aesthetic Improvement by Innovative Translucent Concrete
Authors: Jain Prof. I. M. , Vispute Ajinkya , Shirsath Atul , Sood Devang
Published: June 2023

Abstract: Concrete has been used since Roman times for the development of infrastructure and housing, but its basic components have remained the same. Three ingredients make up the dry mix: coarse aggregate, consisting of larger pieces of material like stones or gravel; fine aggregate, made up of smaller particles such as sand; and cement, a very fine powder material that binds the mix togetherwhen water is added. Just a few decades ago concrete was often misunderstood, disliked and captured by its image fixed due to the rapid urbanization of the 1960s. But since that time, concrete has made considerable progress, not only in technical terms, but also inaesthetic terms. It is no longer the heavy, cold and grey material of the past; it has become beautiful and lively. By research and innovation, newly developed concrete has been created which is more resistant, lighter, white or coloured, etc. Concrete has learned to adapt to almost all new challenges that appeared. In 2001, the concept of translucent concrete was first put forward by Hungarian architect Aron Losonzi at the Technical University of Budapest, and the first translucent concrete block was successfully produced by mixing large amount of glass fibre into concrete in 2003, named as LiTraCon. The translucent concrete mainly focuses on transparency and its objective of application pertains to green technology and artistic finish. It is the “combination of optical fibres and fine concrete”. At present, green structures focus greatly on saving energy with indoor thermal systems. Therefore, it is imperative to develop a new functional material to satisfy the structure in terms of safety monitoring (such as damage detection, fire warning), environmental protection and energy saving and artistic modelling. Due to globalization and construction of high-rise building, the space between buildings is reduced; this causes to increasing the use of non- renewable energy sources, so therefore there is a need of smart construction technique like green building and indoor thermal system. Translucent concrete (Transparent concrete) is new technique different from normal concrete
Smart Helmet Using GSM Module and Ardiuno
Authors: Khangar Dhawal
Published: June 2023

Abstract: Accidents have become a serious problem in recent years. As the number of accidents continues to rise, efforts are made to prevent them and mitigate their effects. The rules of the road do not matter in our society, and they are routinely disregarded. India ranks first in terms of the number of two-wheeler accidents and deaths resulting from them. Using a smart helmet, we provide safety with magnificent and brilliant features by adopting a different perspective. The smart helmet is a GSMbased initiative. It is a helmet with advanced features that enhance the driving experience and make driving safer. The primary objectives of our product are to automate the existing non-automated road safety medical sector, to provide prompt medical assistance to victims of road accidents, and to require riders to wear helmets. To ensure that the biker is wearing a helmet, we are utilizing two modules, one on the helmet and one on the bike, which will operate in tandem. For this, a radio frequency module is used. We are utilizing a GSM800L module with an RS-32 interface that is both GSM and GRPS compatible. In addition, we use Arduino kit to store and operate the program. We are using an ultrasonic sensor that detects an accident and sends a signal to Arduino, which then sends commands to a GSM module that calls/SMS an ambulance and family members. Thus, instant assistance is provided. We aimed to make this intelligent, integrated helmet affordable
Gender equality and workplace diversity in a school division office
Authors: G. Cristales Asher , A. Haguisan III Ismael , B. Sagala Geff
Published: June 2023

Gender equality promotes equal rights, responsibilities, and opportunities for all genders. Nowadays, organizations are adopting a globally competitive environment with programs that promote diversity, inclusion, and non-discrimination policies. This study aimed to determine the extent of the practice of gender equality and workplace diversity in a School Division Office. The respondents were 110 non-teaching employees who completed a research questionnaire. This study utilized a descriptive comparative-correlational research design. The results indicated a high extent of practice for gender equality and an even higher extent for workplace diversity. Additionally, the results revealed a significant relationship between gender equality and workplace diversity. Therefore, employees demonstrate a commitment to practicing gender equality within their diverse workplace, fostering a multicultural setting.
Avoiding symmetry roadblocks and minimizing the measurement overhead of adaptive variational quantum eigensolvers
Authors: Shkolnikov V. O. , Mayhall Nicholas J. , Economou Sophia E. , Barnes Edwin
Published: June 2023

Quantum simulation of strongly correlated systems is potentially the most feasible useful application of near-term quantum computers. Minimizing quantum computational resources is crucial to achieving this goal. A promising class of algorithms for this purpose consists of variational quantum eigensolvers (VQEs). Among these, problem-tailored versions such as ADAPT-VQE that build variational ansätze step by step from a predefined operator pool perform particularly well in terms of circuit depths and variational parameter counts. However, this improved performance comes at the expense of an additional measurement overhead compared to standard VQEs. Here, we show that this overhead can be reduced to an amount that grows only linearly with the number n of qubits, instead of quartically as in the original ADAPT-VQE. We do this by proving that operator pools of size 2n−2 can represent any state in Hilbert space if chosen appropriately. We prove that this is the minimal size of such "complete" pools, discuss their algebraic properties, and present necessary and sufficient conditions for their completeness that allow us to find such pools efficiently. We further show that, if the simulated problem possesses symmetries, then complete pools can fail to yield convergent results, unless the pool is chosen to obey certain symmetry rules. We demonstrate the performance of such symmetry-adapted complete pools by using them in classical simulations of ADAPT-VQE for several strongly correlated molecules. Our findings are relevant for any VQE that uses an ansatz based on Pauli strings.
Classification of measurement-based quantum wire in stabilizer PEPS
Authors: Herringer Paul , Raussendorf Robert
Published: June 2023

We consider a class of translation-invariant 2D tensor network states with a stabilizer symmetry, which we call stabilizer PEPS. The cluster state, GHZ state, and states in the toric code belong to this class. We investigate the transmission capacity of stabilizer PEPS for measurement-based quantum wire, and arrive at a complete classification of transmission behaviors. The transmission behaviors fall into 13 classes, one of which corresponds to Clifford quantum cellular automata. In addition, we identify 12 other classes.
QIYAS SEBAGAI SUMBER HUKUM ISLAM
Authors: Amin Maimun Abdurrahman
Published: June 2023

In Islamic law, qiyas is a solution offered for various legal cases that are not explicitly stated in the proposition in the sources of Islamic law. It is known that Imam Shafi'i was the originator of the concept of qiyas. In his view, various legal cases in Muslim societies that are not clearly regulated in the Qur'an or Sunnah can be resolved through qiyas, either in the form of qiyas jaly or qiyas khafi. Everyone knows that Islamic law is contained in the Koran, the prophetic traditions, the opinions of the early generations of scholars, the consensus and controversies among them, has a high intellectual capacity and sharp analysis whereby he can identify obscure facts, and can become al-Qais. The concept of qiyas consists of four elements of al-ashl, namely the original law derived from the text, al-far, or from an al-'illah. A qiyas may not go beyond the text of the main sources of Islamic law, because it is taken from existing texts.
The current state of sustainability reporting: Evidence from publicly listed financial institutions
Authors: Legaspi Joy Lynn Robosa
Published: June 2023

In compliance with the Philippine Securities and Exchange Commission (SEC) sustainability reporting guidelines, this paper aims to determine the financial institutions’ reporting formats, standards, and frameworks for sustainability reporting. It explores how they prioritize the 17 United Nations Sustainable Development Goals (UN SDGs) and contribute to the specific UN SDGs (Philippine Securities and Exchange Commission, 2019; United Nations [UN], 2015). The annual and sustainability reports were gathered from the Philippine Stock Exchange (PSE) and companies’ websites of 30 publicly listed financial institutions from 2019 to 2021. Using a descriptive research design, this study found that the SEC sustainability reporting template and standalone report are the most common reporting formats. The Global Reporting Initiative (GRI) Standards are the most widely used by Philippine publicly listed financial institutions. Although they support all 17 UN SDGs, the study denotes that SDG 1, no poverty, and SDG 8, decent work and economic growth, are the most important goals aligned with their business activities. This indicates that they comply with the requirements set by the Philippine SEC sustainability reporting guidelines. Their sustainability achievements show their commitment to the UN SDGs. The guidelines drive them to assess and manage their organization’s economic, environmental, and social aspects, encouraging transparency and accountability through public disclosures.
In Salmonella enterica, the pathogenicity island 2 (SPI-2) regulator PagR regulates its own expression and the expression of a five-gene operon that encodes transketolase C
Authors: Escalante-Semerena Jorge , Parks Anastacia R. , McCormick Regan D. , Byrne Jordan A.
Published: June 2023

The enteropathogen Salmonella enterica subsp. enterica sv.
Typhimurium str. LT2 (hereafter S. Typhimurium) utilizes a
cluster of genes encoded within the pathogenicity island 2 (SPI-2) of
its genome to proliferate inside macrophages. The expression of SPI-2 is
controlled by a complex network of transcriptional regulators and
environmental cues, which now include a recently characterized
DNA-binding protein named PagR. Growth of S. Typhimurium in low
phosphate low magnesium medium mimics conditions inside macrophages.
Under such conditions, PagR ensures SPI-2 induction by upregulating the
transcription of slyA, a known activator of SPI-2. Here we report
that PagR represses the expression of a divergently transcribed
polycistronic operon that encodes the two subunits of transketolase TktC
( i.e., tktD, tktE) of this bacterium. Transketolases contribute
to the non-redox rearrangements of phosphorylated sugars of the pentose
phosphate pathway, which provide building blocks for amino acids,
nucleotides, cofactors, etc. We also demonstrate that PagR represses the
expression of its own gene and define two PagR binding sites between
stm2344 and pagR.
CLINICAL AND ELECTROPHYSIOLOGICAL OUTCOMES OF LEFT BUNDLE AREA PACING COMPARED TO BI-VENTRICULAR PACING: AN UPDATED META-ANALYSIS
Authors: Lakshman Harini , Chowdhury Medhat , Ahmed Ammar , Woods Everett , Flemengos George , Abdou Claudine , Kumar Ashish , Patel Harshil , Zughaib Marcel , Bradley Christopher
Published: June 2023

The Left bundle branch area pacing (LBBAP) is a novel pacing strategy
that utilizes the conduction system distal to the left bundle branch
block level for direct activation of the left bundle and the right
ventricular myocardium. Our meta-analysis compared the structural,
electrophysiological, clinical, and procedural outcomes of LBBAP and
Bi-ventricular pacing (BVP). The meta-analysis included two randomized
control trials and showed significant reductions in left ventricular
systolic and diastolic volumes with LBBAP compared to BVP, along with a
statistically significant decrease in QRS duration, NYHA class, and
heart failure hospitalizations. Fluoroscopic time was also significantly
shorter in the LBBAP group. However, no significant change in LV
ejection fraction was noted. Although not statistically significant,
procedural complications were slightly higher in the LBBAP group. Our
findings suggest that LBBAP may be a superior alternative to standard
BVP in improving structural and electrophysiological components and
clinical components of cardiomyopathy, including NYHA class and heart
failure hospitalizations. LBBAP is a more physiological pacing strategy
that results in normal ventricular activation and may be a viable
alternative to BVP for cardiac synchronization therapy.
Subtotal Cricoid Cartilage Resection and Crico-tracheal Reconstruction for Papillary Thyroid Carcinoma Involving Cricoid
Authors: Pang Feng , Xie Liangen , Zhuang Shimin , Xie Meiguang , Wu Lijiao , Liu Tianrun
Published: June 2023

Currently, there is some controversy surrounding surgery for papillary
thyroid carcinoma (PTC) that involves more than half of the cricoid
cartilage, as some studies suggest that partial cricoidectomy may cause
tracheal stenosis and total laryngectomy may be necessary. The aim of
this study was to describe a new technique for subtotal cricoid
resection and crico-trachea reconstruction that preserves laryngeal
function. A 51-year-old man with recurrent PTC underwent subtotal
cricoid cartilage resection, tracheal resection and crico-tracheal
reconstruction. The PTC had spread to the frontal and right lateral
parts of the cricoid cartilage and the 1st to 3rd tracheal rings. The
surgery involved removing three quarters of the cricoid cartilage and
the 1st to 4th tracheal rings, and modifying, rotating, and anastomosing
the remaining trachea to the remaining part of the cricoid cartilage.
The procedure was successful in completely removing the tumor,
preserving speech function, and avoiding tracheal stenosis. The patient
did not experience dyspnea after tracheal cannula removal. This novel
crico-trachea reconstruction surgery shows promise in preserving
speaking function while avoiding complications associated with partial
cricoidectomy.
Origin of CMS-PET1 cytotype in cultivated sunflower: a new insight
Authors: Azarin Kirill , Usatov Alexander , Kasyanova Alexandra , Makarenko Maksim , Gavrilova Vera
Published: June 2023

The vast majority of commercial sunflower hybrids worldwide are produced
using cytoplasmic male sterility (CMS) of the PET1 type, resulting from
the interspecific hybridization of Helianthus petiolaris with Helianthus
annuus. In this study, the open reading frame, orfH522, associated with
the CMS-PET1 phenotype, was revealed for the first time in the
3’-flanking region of the mitochondrial atpA gene in wild H. annuus. An
analysis of whole genome data from 1089 accessions showed that the
frequency of occurrence of CMS-orfH522 in wild H. annuus populations is
3.58%, while in wild H. petiolaris populations, it is 1.26%. The
presence of additional genomic data with insufficient coverage of the
orfH522 sequence indicates that the potential frequency of occurrence of
CMS-orfH522 in natural sunflower populations may be two times higher.
Based on these results and previous studies, PET1-CMS was suggested to
be a natural cytotype of H. annuus, and the appearance of the CMS
phenotype in cultivated sunflowers is associated with the loss of
stabilizing nuclear genes of fertility restorers, which occurred during
interspecific hybridization. These data may explain the patterns of
differential cytoplasmic and nuclear introgression occurring in wild
sunflower and are useful for further evolutionary studies.
Early onset Colorectal Cancer: A Narrative Review
Authors: Lingas Elvina Clara
Published: June 2023

Colorectal cancer remains a leading cause of cancer related deaths and
there has been a rise in the incidence of early onset colon cancer or
colon cancer diagnosed before the age of 50 years old. Early onset CRC
(colorectal cancer) has several differences in clinical presentation as
well as histopathology, genetics alteration and molecular profiling.
Demographic variance also exists in both the developing and developed
countries. Increasing obesity and lifestyle disorder in younger
population may influence this trend. Some studies have observed that
early onset CRC may have worse outcomes than older populations. This
narrative review aims to highlight the pathogenesis of early onset CRC,
as well as its clinical presentation, treatment, prognosis and how it
differs from late-onset CRC.
Advancing rare cancer research by MALDI mass spectrometry imaging: Applications, challenges and future perspectives in sarcoma
Authors: Stillger Maren , Li Mujia , Hönscheid Pia , Neubeck Cläre von , Föll Melanie
Published: June 2023

MALDI mass spectrometry imaging (MALDI imaging) is uniquely suited to
advance cancer research by measuring spatial distribution of endogenous
and exogenous molecules directly from thin tissue sections. These
molecular maps provide valuable insights into various aspects of basic
and translational cancer research, including spatial tumor and tumor
microenvironment biology, pharmacological interventions, and patient
stratification. However, despite these advantages, the utilization of
MALDI imaging in studying rare cancers, which comprise approximately
20% of all cancers, remains limited. Rare cancers pose unique
challenges in medical research, resulting in understudied entities with
suboptimal management and outcomes. In this review, we explore the value
of MALDI imaging in sarcoma, as an example of a highly heterogeneous and
challenging rare cancer. We summarize existing MALDI imaging studies in
sarcoma and outline potential future applications. In addition, we
address the specific challenges encountered when employing MALDI imaging
to rare cancers, and propose solutions, including the utilization of
formalin-fixed paraffin-embedded tissues, multi-site studies,
implementation of multiplexed experiments, and considerations for data
sharing practices. Through this review, we aim to inspire collaboration
between MALDI imaging researchers and clinical colleagues, to deploy the
unique capabilities of MALDI imaging in rare cancer research,
particularly in the context of sarcoma.
Plant-derived environmental DNA complements diversity estimates from traditional arthropod monitoring methods but outperforms them detecting plant-arthropod interactions
Authors: Weber Sven , Stothut Manuel , Mahla Lisa , Kripp Alanah , Hirschler Lena , Lenz Nina , Junker Anneke , Künzel Sven , Krehenwinkel Henrik
Published: June 2023

Our limited knowledge about the ecological drivers of global arthropod
decline highlights the urgent need for more effective biodiversity
monitoring approaches. Monitoring of arthropods is commonly performed
using passive trapping devices, which reliably recover diverse
communities, but provide little ecological information on the sampled
taxa. Especially the manifold interactions of arthropods with plants are
barely understood. A promising strategy to overcome this shortfall is
environmental DNA (eDNA) metabarcoding of arthropods from plant material
they have interacted with. However, the accuracy of this approach has
not been sufficiently tested. In four experiments, we exhaustively test
the comparative performance of plant-derived eDNA from surface washes of
plants and homogenized plant material against traditional monitoring
approaches. We show that the recovered communities of plant-derived eDNA
and traditional approaches only partly overlap, with eDNA recovering
various additional cryptic taxa. This suggests eDNA as a useful
complementary tool to traditional monitoring. Despite the differences in
recovered taxa, estimates of community α- and β-diversity between both
approaches are well correlated, highlighting the utility of eDNA as a
broad scale tool for community monitoring. Last, eDNA outperforms
traditional approaches in the recovery of plant-specific arthropod
communities. Unlike traditional monitoring, eDNA revealed fine-scaled
community differentiation between individual plants and even within
plant compartments. Especially specialized herbivores are better
recovered with eDNA. Our results highlight the value of plant derived
eDNA analysis for large-scale biodiversity assessments that include
information about community level interactions.
A Chinese Pediatric cystic fibrosis patient with the c.1624G>T, p. Gly542x / c.223C>T, p. Arg75x genotype
Authors: Zhang Rui , Sun Yao
Published: June 2023

In conclusion, we present this case in order to complement CFTR gene
mutations data of Chinese children with cystic fibrosis and improve
clinicians’ understanding of this disease in China. Besides, with the
development of molecular biology technology, gene detection was expected
to play an important role in the early diagnosis, early treatment, and
prognosis improvement of the disease.
Comparison of Porcine Versus Bovine Surfactant in preterm respiratory distress syndrome: Evidence from real world data. A multicenter collaboration from Karnataka
Authors: Aradhya Abhishek , S Sharath Ghalige , Madarkar Babu , HV Pruthvishree , Venkatagiri Praveen , Urs Prashant , Ngangom Daizy , Rangaiah Sandeep , Kumar Vimal , Harini Chinnaraja , Bansal Arpna , P Maneesha Halkar
Published: June 2023

BACKGROUND & OBJECTIVES: Porcine surfactant (200 mg/kg initial
dose) seems to be superior over bovine surfactants (100 mg/kg) in
respiratory distress syndrome (RDS). There is limited data on choice of
surfactant from the developing world. Logically using higher doses of
porcine surfactant comes with additional burden of cost. We decided to
evaluate the clinical effect of different types of surfactants.
METHODS: A retrospective analysis was conducted from August
2019 to December 2022 in 6 tertiary centres. Neonates 24-34 weeks of
gestation with RDS requiring either porcine (200 mg/kg) or bovine
surfactant (100 mg/kg) were enrolled. The proportion of combined
outcomes of death and or CLD, redosing and other morbidities in either
group were analysed. The subgroup of preterm >28 weeks and
outcomes between different surfactants were analysed. RESULTS:
Out of 1149 eligible babies, 302 (26%) received surfactant after
stabilisation with CPAP. 158 received porcine and 144 received bovine
surfactant via INSURE technique. There was a higher combined outcome of
death or CLD in porcine compared to the bovine group [48 (30%) vs 20
(13%), OR:2.7; 95% CI:1.5-4.8; p=0.001] and similar combined
outcomes in >28 weeks sub-group. Redosing [27 (17%) Vs
18 (12%), OR:1.4; 95% CI:0.7-2.7; p=0.2] was similar. Other
morbidities like air leak, invasive ventilation, CPAP duration were
similar between both the groups and different types of surfactants.
CONCLUSION: Porcine surfactant at 200mg/kg had similar combined
outcomes of death/ CLD and redosing compared to bovine surfactant in
preterm >28 weeks. Considering the cost burden in the
developing world, the efficacy needs evaluation in randomised clinical
trials.