bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable employability of internal stakeholders of non-governmental organisations
Authors:   Uniwersytet Ekonomiczny w Krakowie, Wiśniewska Sylwia , Wiśniewski Kamil ,   Uniwersytet Jana Kochanowskiego w Kielcach
Published: April 2023

Nowadays, the growing importance of non-governmental organisations and sustainable employment in the modern labour market is emphasised in the literature on the subject and in economic practice. A systematic review of the literature confirms the lack of research on the sustainable employability of internal NGO stakeholders. Because the issue of sustainable employability in non-governmental organisations is an area that requires exploration, this study attempts to fill this identified research gap. In the context of the stated premises, the analysis and assessment of sustainable employability of internal stakeholders of non-governmental organisations were adopted as the main objective of the article. For this study, a systematic review of literature, and also empirical research, was carried out. The data collection technique in the study was a diagnostic survey method and a Computer-Assisted Web Interview (CAWI). The sustainable employability of internal stakeholders of non-governmental organisations in Poland has been assessed thanks to empirical research. The research results showed that the respondents demonstrated a high level of sustainable employability. In addition, the respondents were assessed using various organizational solutions aimed at developing sustainable employability in the modern labour market. The obtained research results complement the diagnosed gap in knowledge, indicating that the respondents considered health prevention programs a priority solution to ensure ergonomic and safe working conditions for people of different ages.
Electrophysiological Correlates of Proactive Control and Binding Processes during Task Switching in Tourette Syndrome
Authors: Wehmeyer Laura , Schüller Canan Beate , Gruendler Theo O. J. , Huys Daniel , Kuhn Jens , Ullsperger Markus , Visser-Vandewalle Veerle , Andrade Pablo , Baldermann Juan Carlos , Schüller Thomas
Published: April 2023

The occurrence of tics in Tourette syndrome (TS) has often been linked to impaired cognitive control, but empirical findings are still inconclusive. A recent view proposes that tics may be the result of an abnormally strong interrelation between perceptual processes and motor actions, commonly referred to as perception-action binding. The general aim of the present study was to examine proactive control and binding effects in the context of task switching in adult human patients with TS and matched healthy controls. A cued task switching paradigm was employed in 24 patients (18 male, 6 female) and 25 controls while recording electroencephalography (EEG). Residue iteration decomposition (RIDE) was applied to analyze cue-locked proactive cognitive control and target-locked binding processes. Behavioral task switching performance was unaltered in patients with TS. A cue-locked parietal switch positivity, reflecting proactive control processes involved in the reconfiguration of the new task did not differ between groups. Importantly, target-locked fronto-central (N2) and parietal (P3) modulations, reflecting binding processes between perception and action, differed between groups. Underlying neurophysiological processes were best depicted after temporal decomposition of the EEG signal. The present results argue for unaltered proactive control but altered perception-action binding processes in the context of task switching, supporting the view that the integration of perception and action is processed differently in patients TS. Future studies should further investigate the specific conditions under which binding may be altered in TS and the influence of top-down processes, such as proactive control, on bindings.
Microscale Neuronal Activity Collectively Drives Chaotic and Inflexible Dynamics at the Macroscale in Seizures
Authors: Burrows Dominic R. W. , Diana Giovanni , Pimpel Birgit , Moeller Friederike , Richardson Mark P. , Bassett Dani S. , Meyer Martin P. , Rosch Richard E.
Published: April 2023

Neuronal activity propagates through the network during seizures, engaging brain dynamics at multiple scales. Such propagating events can be described through the avalanches framework, which can relate spatiotemporal activity at the microscale with global network properties. Interestingly, propagating avalanches in healthy networks are indicative of critical dynamics, where the network is organized to a phase transition, which optimizes certain computational properties. Some have hypothesized that the pathologic brain dynamics of epileptic seizures are an emergent property of microscale neuronal networks collectively driving the brain away from criticality. Demonstrating this would provide a unifying mechanism linking microscale spatiotemporal activity with emergent brain dysfunction during seizures. Here, we investigated the effect of drug-induced seizures on critical avalanche dynamics, usingin vivowhole-brain two-photon imaging of GCaMP6s larval zebrafish (males and females) at single neuron resolution. We demonstrate that single neuron activity across the whole brain exhibits a loss of critical statistics during seizures, suggesting that microscale activity collectively drives macroscale dynamics away from criticality. We also construct spiking network models at the scale of the larval zebrafish brain, to demonstrate that only densely connected networks can drive brain-wide seizure dynamics away from criticality. Importantly, such dense networks also disrupt the optimal computational capacities of critical networks, leading to chaotic dynamics, impaired network response properties and sticky states, thus helping to explain functional impairments during seizures. This study bridges the gap between microscale neuronal activity and emergent macroscale dynamics and cognitive dysfunction during seizures.

SIGNIFICANCE STATEMENTEpileptic seizures are debilitating and impair normal brain function. It is unclear how the coordinated behavior of neurons collectively impairs brain function during seizures. To investigate this we perform fluorescence microscopy in larval zebrafish, which allows for the recording of whole-brain activity at single-neuron resolution. Using techniques from physics, we show that neuronal activity during seizures drives the brain away from criticality, a regime that enables both high and low activity states, into an inflexible regime that drives high activity states. Importantly, this change is caused by more connections in the network, which we show disrupts the ability of the brain to respond appropriately to its environment. Therefore, we identify key neuronal network mechanisms driving seizures and concurrent cognitive dysfunction.
Two Oscillatory Correlates of Attention Control in the Alpha-Band with Distinct Consequences on Perceptual Gain and Metacognition
Authors: Trajkovic Jelena , Di Gregorio Francesco , Avenanti Alessio , Thut Gregor , Romei Vincenzo
Published: April 2023

Behavioral consequences and neural underpinnings of visuospatial attention have long been investigated. Classical studies using the Posner paradigm have found that visual perception systematically benefits from the use of a spatially informative cue pointing to the to-be-attended spatial location, compared with a noninformative cue. Lateralized α amplitude modulation during visuospatial attention shifts has been suggested to account for such perceptual gain. However, recent studies on spontaneous fluctuations of prestimulus α amplitude have challenged this notion. These studies showed that spontaneous fluctuations of prestimulus α amplitude were associated with the subjective appreciation of stimulus occurrence, while objective accuracy was instead best predicted by the frequency of α oscillations, with faster prestimulus α frequency accounting for better perceptual performance. Here, in male and female humans, by using an informative cue in anticipation of lateralized stimulus presentation, we found that the predictive cue not only modulates preparatory α amplitude but also α frequency in a retinotopic manner. Behaviorally, the cue significantly impacted subjective performance measures (metacognitive abilities [meta-d′]) and objective performance gain (d′). Importantly, α amplitude directly accounted for confidence levels, with ipsilateral synchronization and contralateral desynchronization coding for high-confidence responses. Crucially, the contralateral α amplitude selectively predicted interindividual differences in metacognitive abilities (meta-d′), thus anticipating decision strategy and not perceptual sensitivity, probably via excitability modulations. Instead, higher perceptual accuracy both within and across participants (d′) was associated with faster contralateral α frequency, likely by implementing higher sampling at the attended location. These findings provide critical new insights into the neural mechanisms of attention control and its perceptual consequences.

SIGNIFICANCE STATEMENTPrior knowledge serves the anticipation of sensory input to reduce sensory ambiguity. The growing interest in the neural mechanisms governing the integration of sensory input into our internal representations has highlighted a pivotal role of brain oscillations. Here we show that distinct but interacting oscillatory mechanisms are engaged during attentional deployment: one relying on α amplitude modulations and reflecting internal decision processes, associated with subjective perceptual experience and metacognitive abilities; the other relying on α frequency modulations and enabling mechanistic sampling of the sensory input at the attended location to influence objective performance. These insights are crucial for understanding how we reduce sensory ambiguity to maximize the efficiency of our conscious experience, but also in interpreting the mechanisms of atypical perceptual experiences.
Pengaruh Campuran Air-Nanopartikel CuO sebagai Coolant dan Laju Aliran terhadap Parameter Perpindahan Kalor pada Radiator
Authors: Himawan Andri , Anis Samsudin , Firmansyah Hendrix Noviyanto
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pengaruh fraksi volume dan debit fluida terhadap parameter perpindahan kalor di dalam sistem pendingin radiator Honda Vario. Penelitian dilakukan dengan menggunakan sebuah alat uji yang melibatkan sebuah radiator sebagai pendingin utama. Temperatur fluida masuk dijaga konstan sesuai dengan temperatur kerja mesin. Pengukuran temperatur dilakukan pada variasi debit dan konsentrasi fluida menggunakan termometer digital. Variasi yang digunakan dalam penggunaan fraksi volume fluida yaitu sebesar 0%, 0,1%, 0,3%, dan 0,5 %. Sedangkan variasi debit fluida yang digunakan sebesar 12 lpm, 18 lpm, dan 24 lpm yang diukur menggunakan flowmeter. Perubahan parameter perpindahan kalor paling tinggi ditemukan pada fraksi dan debit yang besar. Namun, pada fraksi volume yang lebih tinggi, bilangan Reynlods akan cenderung menurun. Untuk mendapatkan laju perpindahan kalor dan pendinginan yang baik, maka digunakan fraksi dan debit fluida yang lebih tinggi. Penggunaan nanofluida akan membantu proses pengurangan kalor yang ada di dalam sistem pendingin radiator.
Pengaruh Kecepatan Angin terhadap Daya Keluaran Turbin Angin Tipe Hellical Savonius dengan 3 Sudu
Authors: Sukmana Adree Gumilang , Aryadi Widya , Sunyoto Sunyoto
Published: April 2023

This research aimed to find out the effect of wind speed on power output of savonius type wind turbine with 3 hellical blades. Variations of wind speed were obtained through a predetermined time and location of observation. The data collected consist of wind speed, voltage, electric current, RPM, and the power. The observation showed that wind speed affected the power turbine output. Time and location of the test that did not yield power output namely: at 09.00 am in the Marina Beach and at 12.00 pm in the GSG UNNES. The highest output power obtained at 06.00 pm in both areas. It was concluded that the wind speed in the morning and midday yield in lowest power output of turbine, while in the afternoon produce the highest power.
Pengaruh Temperatur Bahan Bakar Biodiesel Minyak Lemak Sapi Terhadap Performa Mesin Diesel Multi Silinder
Authors: Chalid Ayatullah Naufal , Aryadi Widya , Karnowo Karnowo
Published: April 2023

Combustion of biodiesel is a common problem on diesel engine. One way to overcome this problem is by adding biodiesel to the diesel fuel, in this case, beef tallow. This research used description method by experimenting with biodiesel fuel with temperature variation ranged from 30, 40, 50, 60, 70 °C. The phenomenon observed during the experiment process is attributed to the theoretical review and previous studies. The result of this research shown that there were no slight improvement on the power and torque generated. At 40, the diesel fuel mixed with beef tallow biodiesel generated the 56,81 kW power and 136,30 Nm torque , while with conventional diesel fuel, the power generated at 30c was 55,62 kW and the torque was 163,6 Nm.
KOMPOR EKONOMIS BERBAHAN BAKAR OLI BEKAS
Authors: Putra Athallahariq Fadhil Kamal , Fitriyana Deni Fajar , Ro'is Ridho Fachrur , Pangestu Wahyu Dwi , Abdullah Lutfhi
Published: April 2023

This study aims to determine the design of a stove (burner) fueled by used oil, along with its specifications and to find out the test results using a stove (burner) burning used oil. Departing from the lack of utilization of used oil waste and the absence of good tools to utilize used oil. On the other hand, when used as fuel, used oil does not produce complete combustion. This study uses the French design model. This study concluded that the designed stove (burner) has a large shape compared to the burner in general. The stove (burner) reaches a pressure of 3.5 bar with a temperature of 1127 °C. The flames produced by used oil are orange. Comparison of fuel results in data that LPG is 16 minutes faster than used oil in aluminum smelting. The highest flame length is 1.57 m at a variation of 3 bar air pressure and the lowest is 0.83 m at a pressure of 1 bar. There is an influence of pressure variations on the combustion temperature with a minimum and maximum temperature reaching the highest point with a pressure of 2.5 bar with a temperature of 118 °C and 994 °C while the lowest point is at a minimum and maximum temperature at a pressure of 1 bar with a temperature of 80.4 ° C and 662 °C at 0.5 bar pressure. Fuel consumption time with a distance variation of 2200 km produces a fairly short time of 12 minutes 25 seconds. While the consumption time obtained from the variation of the distance of 1800 km is 17 minutes 11 seconds.
PENGARUH WAKTU EKSTRUKSI BAHAN EVAPORATION BOATS, GRAFIT DAN SEMEN CASTABLE PADA MESIN EKSTRUDER TERHADAP DENSITAS, POROSITAS DAN KEKUATAN IMPAK
Authors: Akbar Galang Tamami , Rusiyanto Rusiyanto , Sunyoto Sunyoto , Kriswanto Kriswanto , Firmansyah Hendrix Noviyanto
Published: April 2023

Waste is one of the main problems in Indonesian industry. The utilization of metal waste is very much needed by the metal smelting industry to melt and reshape to become goods that have more selling value. There are many kinds of waste obtained from the metallurgical manufacturing industry, one of which is material evaporation boats. Refractory materials commonly used for crucibles have not yet produced good refractories and the price is still expensive, so research on Evaporation Boats is needed for more utilization and advantages. This study aims to determine the effect of the extrusion time of evaporation boats, graphite and castable cement on the density, porosity, and impact strength of crucible materials. Variations in extrusion time used in this study were 45 minutes, 90 minutes and 135 minutes. The materials used are 70% evaporation boats by weight, 15% graphite, 15% castable cement, and mixed with 15% water of the total weight. The test results showed the highest density value was 2.05 g/cm3 at an extrusion time of 135 minutes, and the lowest was 2.03 g/cm3 at an extrusion time of 45 minutes. The highest porosity value was 5.5% at an extrusion time of 45 minutes, and the lowest was 2.4% at an extrusion time of 135 minutes. The highest impact strength value was 0.005611579 J at an extrusion time of 135 minutes, and the lowest was 0.005117523 J at an extrusion time of 45 minutes. From the resulting data, it is known that 1.) there is an effect of extrusion time on the density value. The longer the extrusion time, the higher the density value. 2.) There is an effect of extrusion time on the porosity value. The faster the extrusion time, the higher the porosity value. 3.) There is an effect of extrusion time on the impact strength. The longer the extrusion time, the higher the impact.
ВИВЧЕННЯ ЛІТЕРАТУРНОГО ЕКСПРЕСІОНІЗМУ В СЕРЕДНІЙ ШКОЛІ: ДІАЛОГІЧНА ТЕХНОЛОГІЯ
Authors: ТОКМАНЬ ГАННА
Published: April 2023

Стаття присвячена методиці вивчення експресіонізму на уроках української і зарубіжної літератури в середній школі, у центрі якої реалізація технології діалогічного навчання. На уроках літератури ця технологія сприяє інтелектуальній активності та спілкуванню учнів під час інтерпретації художнього тексту. Дослідниця запропонувала систему діалогів різноманітних типів, у результаті яких учні глибоко осмислять як сутність експресіонізму, так і стиль конкретного автора. Важливим є демонстрування експресіоністичних творів інших видів мистецтв.
Analizando la Gestión del Conocimiento y su relación con la Gestión de Proyectos de Desarrollo de Software y el Razonamiento Basado en Casos
Authors: Huayna Dueñas Ana María
Published: April 2023

El objetivo de este estudio fue analizar el grado de relación de la Gestión del Conocimiento con la Gestión de Proyectos de Desarrollo de Software y el Razonamiento Basado en Casos; para lo cual se realizó la demostración de las hipótesis formuladas, mediante un paquete estadístico. La presente investigación es básica con un enfoque cuantitativo, de nivel descriptivo-correlacional, con diseño no experimental. La muestra estuvo conformada por 44 empresas especializadas en proyectos de desarrollo de software. El instrumento utilizado fue un cuestionario a escala Likert con cinco elecciones específicas. Los resultados demostraron que el coeficiente de correlación Rho de Spearman obtuvo un valor de 0,643, el cual se considera como una correlación moderada, y un sigma (bilateral) de 0.000 (p < 0,05). Asimismo, se hallaron diferencias significativas en las dimensiones de las variables estudiadas; a través de sus indicadores respectivos. En conclusión, sea aprecia que la Gestión del Conocimiento se relaciona significativamente con la Gestión de Proyectos de Desarrollo de Software y el Razonamiento Basado en Casos.
Neurosono-net: deep learning para la detección de anomalías del cerebro fetal mediante ultrasonografía
Authors: Rojas-Azabache Carlos , Romero-Olortiga Thalia
Published: April 2023

El diagnóstico de anomalías cerebrales fetales a través del uso de ecografía es importante debido a que las malformaciones congénitas cerebrales son una de las anomalías más comunes. La prevalencia de estas anomalías es desconocida, ya que algunos casos no se manifiestan hasta etapas posteriores de la vida y la mayoría ocurren en personas que no están en grupos de riesgo. Muchas de estas anomalías no tienen tratamiento disponible y pueden ser graves y permanentes, por lo que es importante realizar un diagnóstico y pronóstico precisos para poder brindar asesoramiento y manejo multidisciplinario. El objetivo de este trabajo es implementar una arquitectura de deep learning que utilice imágenes de ultrasonido de cerebro fetal para la detección automática de anomalías en los planos estándar. Para ello utilizaremos la arquitectura Faster R-CNN, el cual podría ser de gran utilidad para lugares remotos donde no se cuenta con un profesional especialista en ecografía; a su vez, también puede servir de apoyo para el entrenamiento ecográfico de los profesionales que realicen este procedimiento.
Methodological possibilities of isothermal amplification of nucleic acids for the detection of transgenic events
Authors:   Institute of Food Biotechnology and Genomics, Natl. Academy of Sciences of Ukraine, Korkhovyi Vitaly , Blume Yaroslav ,   Institute of Food Biotechnology and Genomics, Natl. Academy of Sciences of Ukraine, Yemets Alla ,   Institute of Food Biotechnology and Genomics, Natl. Academy of Sciences of Ukraine
Published: April 2023

The technique of loop-mediated isothermal amplification (LAMP) is the relevant topic for today which is covered in this work. The focus is on efficiency, specificity, high accuracy and, at the same time, the availability of this technique for use in laboratories with relatively low funding. The work reflectes on the issues of wide application of this method both in general medical laboratory practice and for detection of GM events. For specialists in the field of molecular biology, genetics, biotechnology, teachers and students of higher educational institutions of III-IV levels of accreditation.
Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction
Authors: Jimenez Maria Teresa Bayo , Hahad Omar , Kuntic Marin , Daiber Andreas , Münzel Thomas
Published: April 2023

During the last two decades, large epidemiological studies have shown that the physical environment, including noise, air pollution or heavy metals, have a considerable impact on human health. It is known that the most common cardiovascular risk factors are all associated with endothelial dysfunction. Vascular tone, circulation of blood cells, inflammation, and platelet activity are some of the most essential functions regulated by the endothelium that suffer negative effects as a consequence of environmental pollution, causing endothelial dysfunction. In this review, we delineate the impact of environmental risk factors in connection to endothelial function. On a mechanistic level, a significant number of studies suggest the involvement of endothelial dysfunction to fundamentally drive the adverse endothelium health effects of the different pollutants. We focus on well-established studies that demonstrate the negative effects on the endothelium, with a focus on air, noise, and heavy metal pollution. This in-depth review on endothelial dysfunction as a consequence of the physical environment aims to contribute to the associated research needs by evaluating current findings from human and animal studies. From a public health perspective, these findings may also help to reinforce efforts promoting the research for adequate promising biomarkers for cardiovascular diseases since endothelial function is considered a hallmark of environmental stressor health effects.
Patent Foramen Ovale-associated Stroke and COVID-19 Vaccination
Authors: Rojko Maja , Cernic Suligoj Natasa , Zorc Metka , Noc Marko
Published: April 2023

Background: COVID-19 infection has been associated with paradoxical thromboembolism through a patent foramen ovale (PFO) and ischaemic stroke. Such events have not been reported after COVID-19 vaccination. The aim of the present study was to investigate PFO-associated stroke during the mass COVID-19 vaccination in Slovenia. Methods: This prospective study, conducted between 26 December 2020 and 31 March 2022, enrolled consecutive patients (≥18 years) with PFO-associated stroke referred for a percutaneous closure to a single interventional facility in Slovenia. Results: A total of 953,546 people aged between 18 and 70 years received at least one dose of a COVID-19 vaccine approved by the European Medicines Agency. Of the 28 patients presenting with PFO-associated stroke, 12 patients (42.9%) were vaccinated prior to the event, of whom nine were women and three were men, aged between 21 and 70 years. Stroke occurred within 35 days after vaccination in six patients (50%). Clinical presentation included motor dysphasia, paresis, vertigo, ataxia, paraesthesia, headache, diplopia and hemianopia. At hospital discharge, 11 patients (91.6%) had at least one residual ischaemic lesion. Conclusion: A temporal coincidence of COVID-19 vaccination and PFO-associated stroke has been described. A potential cause–effect relationship may only be hypothesised.
COVID–19 és haemostasis
Authors: Pfliegler György , Illés Árpád
Published: April 2023

Összefoglaló. A szerzők a SARS-CoV-2 vírus okozta járványnak
(COVID–19) a haemostasist érintő, klinikailag fontosabb szempontjait tekintik át
röviden. Felhívják a figyelmet a thromboemboliás szövődmények súlyossága és
gyakorisága mögött levő patomechanizmus jellegzetességére, vagyis a
Virchow-triász három alkotója időben egyszerre történő aktiválódására. A
továbbiakban a kórállapotot és -lefolyást jelző fontosabb haemostasis
laboratóriumi leleteket érintik, majd rátérnek a megelőzés és a kezelés
kérdéseire, mely utóbbiakat a betegség súlyossági csoportokra történő bontásában
tárgyalják, a jelenlegi nemzetközi irányelvekre támaszkodva. Végezetül egy
összefoglaló táblázatban, a nemzetközi ajánlásokon alapuló, de a hazai
szempontokat is figyelembe vevő, általánosan elfogadható antikoagulálási
útmutatót igyekeznek adni, hangsúlyozva a kezelés személyre szabásának
fontosságát.

Summary. In the present paper the most important, clinically
relevant haemostatic effects of SARS-Cov-2 virus infection (COVID-19) is
reviewed and an awareness is raised of the unique pathomechanism which allows a
concurrent activation of each side of the Virchows’ triad responsible for the
aggressivity of thrombotic events in the disease. Subsequently characteristic
haemostatic prognostic and staging laboratory results are discussed followed by
a brief survey of anticoagulant prophylaxis and therapy in the different
severity stages of the disease. Finally a brief guidance is given based on
various international guidelines with an adoption of current Hungarian situation
and emphasizing the importance of personalized decisions.
Új terápiás lehetőség a cutan T-sejtes lymphomák kezelésében: a mogamulizumab
Authors: Miltényi Zsófia
Published: April 2023

Összefoglaló. A cutan T-sejtes lymphomák a non-Hodgkin lymphomák
heterogén csoportját képviselik. A leggyakoribb altípus a mycosis fungoides,
melynek korai stádiumában az 5 éves betegségspecifikus túlélés 90% körüli, az
előrehaladott stádiumokban azonban csak 30–50%. Az agresszív formák rossz
prognózisúak, nagy betegszámú, randomizált klinikai vizsgálatok hiányában
egységes, hatékony kezelési módszerrel nem rendelkezünk. A szisztémás
lymphoproliferatív betegségek kezelésében egyre inkább előtérbe kerülnek a
célzott terápiás lehetőségek, melyek a cután lymphomákban is hatékonyak
lehetnek. Ezek közül az anti CCR4 antitesttel, a mogamulizumabbal már vannak
kedvező tapasztalatok. Fázis 3 vizsgálat során 28%-os teljes válaszarányt és 7,7
hónapos medián túlélést igazoltak relabáló vagy refrakter mycosis fungoidesben
vagy Sézary-szindrómában szenvedő betegeknél. A leggyakoribb mellékhatások az
infúziós reakciók, a kiütés, hasmenés és krónikus fáradtság voltak. A vizsgálat
eredménye alapján a mogamulizumabot az Európai Gyógyszerügynökség is befogadta
ezen betegcsoport kezelésére, remélhetőleg nemsokára hazánkban is hozzáférhető
lesz.

Summary. Cutaneous T-cell lymphomas represent a heterogeneous group
of non-Hodgkin’s lymphomas. The most common subtype is mycosis fungoides, with
an early 5-year disease-specific survival of around 90%, but only 30–50% in the
advanced stages. Aggressive forms have poor prognosis in the absence of large,
randomized clinical trials we do not have a uniform, effective treatment method.
In the treatment of systemic lymphoproliferative diseases, targeted therapeutic
options are emerging that may be effective in cutaneous lymphomas. Of these, the
anti CCR4 antibody was mogamulizumab there are already positive experiences. In
a phase 3 study, a 28% overall response rate and a median survival of 7.7 months
were demonstrated in patients with relapsed or refractory mycosis fungoides or
Sezary’s syndrome. The most common side effects were infusion reactions, rash,
diarrhea, and chronic fatigue. Based on the results of the study, mogamulizumab
has also been accepted by the European Medicines Agency for the treatment of
this group of patients and will hopefully be available in Hungary soon.
Phase and properties prediction of Al–Ag binary system using thermo-calc
Authors: Ben Festus , Olubambi P. A.
Published: April 2023

The temperature phase diagram stability and physical properties of a binary Silver–Aluminium (Al–Ag) alloy system have been calculated using Thermo-Calc 2021b software at a temperature range of 250–1300 K. Six single-solid phases other than the liquid phase, elemental Ag (fcc_Ag), elemental Al (fcc_Al), hcp_A3, cub_A13, and bcc_Ag were obtained from the equilibrium calculation. Ten regions of the double phase were obtained and evaluated. Three intermediate phases were also obtained from the phase diagram with five invariant reactions, namely one eutectic reaction (at 840.00 K), two peritectic reactions (at 1051.22 K and 1003.18 K), and two peritectoid reactions (at 730.58 K and 881.40 K) were equally found. Sixteen regions other than elemental Ag and Al at 0, and 100, respectively, were obtained. Maximum solid solubility obtained was 5.60 Al mass percent at 730. 58 K for Al in Ag and 58.17 Ag mass percent at 840.00 K for Ag in Al. From the temperature–composition phase diagram, the melting point for pure silver and aluminium were equally inferred as 1234.96 K and 933.50 K, respectively, which agrees with experimental standards. These results play a significant role in the processing of Al–Ag alloy for different industrial-related applications.

Graphical abstract
The domestic wastewater treatment capacity of Spirulina platensis SP4 and the application of the treated wastewater in stimulating rice germination
Authors: Thi Kieu Oanh Nguyen , Thi Thuy Duong , Thi Oanh Doan , Thi Nguyet Vu , Van Nam Nguyen
Published: April 2023

Many scientists are interested in microalgae and cyanobacteria because of their richness in high-value bioactive metabolites (proteins, lipids, vitamins, plant growth regulators, and others). Microalgae and cyanobacteria can be used to produce valuable commodities such as dietary supplements, biofuel, animal feed, and agricultural fertilizer, etc. To improve the economic feasibility of the cyanobacterial product recovery process, it is possible to utilize domestic wastewater as a source of nutrients for their growth. This research focuses on assessing the ability of domestic wastewater treatment and treated domestic wastewater utilization to stimulate BC15 rice-grain sprouting by cyanobacteria Spirulina platensis SP4. Research results showed that S. platensis SP4 grown best in domestic wastewater at the initial density of 0.3 and the wastewater concentration of 100%. The incubation of S. platensis was performed in the laboratory under the condition of 16.8 g/L NaHCO3; aeration during 8 h/day; light: dark cycle of 8:16; light intensity of 5000 lux. Under these conditions S. platensis SP4 could treat N-NH4+, T-N, P-PO43-, T-P and COD well with the treatment efficiency of 96.37, 49.71, 67.05, 65.88 and 95.53%, respectively. The addition of treated domestic wastewater by S. platensis SP4 to BC15 rice grains stimulated the grouting by 99.54 ± 1.25%, which was 1.54 times higher than using the tap water and gave a germination efficiency equivalent to that of the experiments with adding cyanobacteria in standard medium with or without L-tryptophan addition for 48 h. The obtained research results have elucidated the feasibility of employing cyanobacteria in residential wastewater treatment as well as the reuse of treated wastewater for plant development.
Diversity and composition of bacterial communities associated with healthy and bleached coral Fungia sp. in Nha Trang bay, Vietnam
Authors: Van Ngoc Bui , Nhat Huy Chu
Published: April 2023

Coral bleaching is probably caused by the loss of endosymbiotic algae from the host tissue or disturbance of the microbial community composition of corals. In particular, bacteria inhabiting the surface mucus layer of corals are supposed to mediate coral health, but their role in coral bleaching has not been fully clarified. In the present study, we collected mucus samples from bleached and healthy Fungia sp. colonies in Nha Trang bay to investigate biodiversity and bacterial community composition using 16S rRNA gene amplicon next-generation sequencing. The results indicated rich biodiversity and significant changes in bacterial communities between bleached and healthy corals. Two phyla, Proteobacteria and Bacteroidetes, making up approximately 80% of the total bacterial abundance, were predominant in both bleached and healthy samples. Three phyla, Actinobacteria, Planctomycetes, and Cyanobacteria identified as minor taxa, were low in abundance in both samples. However, there were significant differences in bacterial communities at the genus level. Three bacterial genera, Erythobacteria, Synechcococcus CC9902, and Candidatus Actinomarina, involved in coral health protection, were mostly determined in the healthy coral samples. Whereas, five genera, Algicola, Fusibacter, Halodesulfovibrio, Marinifilum, and especially the genus Vibrio, were mainly detected in the bleached corals with a notable increase in relative abundance. Moreover, analysis of alpha and beta diversity (NMDS) also confirmed that there were significant changes in bacterial composition between the bleached and healthy corals (p-value <0.05). These findings suggest that the disturbance of the bacterial community composition living on coral is one of the factors causing coral bleaching, beside environmental factors like pH, temperature, and dissolved oxygen.
In vitro safety evaluation of Bacillus subtilis species complex isolated from Vietnam and their additional beneficial properties
Authors: Thi Lan Anh Hoang , Thi Thanh Hue Le , Hai Linh Bui Nguyen , Tuan Dung Nguyen Huu , Duong Minh Dao , Thi Le Quyen Tran , Trung Trinh Thanh
Published: April 2023

Bacillus genus are Gram-positive, rod shaped, spore-forming, aerobic or facultative anaerobic bacteria, which have the ability to produce a wide variety of enzymes, antimicrobial compounds, vitamins, and carotenoids. Nowadays, Bacillus species have been increasingly proposed for use as probiotics or feed additives as B. amyloliquefaciens, B. licheniformis, B. subtilis, and B. pumilus because of their advantages such as heat-stability of the spores, storage capacity at ambient temperature, and beneficial properties for health. Since microbes are used for customers and livestock, it is critical to substantiate not only the health benefits and efficacy of unique strains but also their safety for the hosts. This study aims to evaluate the in vitro safety and some beneficial properties of Bacillus strains to select potential strains for use in humans or animals. A total of 76 Bacillus strains belonged to the B. amyloliquefaciens and B. subtilis groups were preliminary evaluated for their safety via hemolytic activity. Six non-hemolytic strains were identified and their antibiotic susceptibility, cytotoxicity on the growth of HT29 and Vero cells, extracellular enzyme production, antimicrobial activity, and identification based on 16S rRNA and rpoB gene sequences were studied. Two strains, B. subtilis VTCC 10963 and B. subtilis VTCC 11039, should be considered safe. In addition, these two strains exhibited good extracellular enzyme production (amylase, cellulase, and protease) and strong antibacterial activity against Listeria monocytogenes. Our results support the use of B. subtilis VTCC 10963 and B. subtilis VTCC 11039 for the development of probiotic products and feed additives in the future.
Isolation of α-mangostin from mangosteen (Garcinia mangostana L.) peels and evaluation of its inhibitory activity toward α-glucosidase and α-amylase in the combination with acarbose
Authors: Van Quang Ngo , Hong Minh Nguyen Thi , Mai Phuong Nguyen Thi
Published: April 2023

Using the natural agents with inhibitory activity against digestive enzymes α-glucosidase and α-amylase capable of hydrolyzing carbohydrates into glucose to reduce blood glucose levels in the blood is one of the effective strategies to control diabetes, especially type II diabetes. α-Mangostin (AMG) was proven to have strong biological activities, such as antifungal, antibacterial, anti-inflammatory, anti-cancer. However, the evaluation of the antidiabetic activity of this substance through inhibition of starch hydrolytic enzymes activity has not been fully carried out, especially when they are combined with commercial drugs, such as acarbose. In this study, AMG was isolated from the peels of the mangosteen grown in Vietnam using a simple isolation process with two steps: i) fractionation of the material in n-hexane solvent, and ii) chromatography of n-hexane fraction on a silica gel column combined with crystallization. The α-glucosidase inhibitory activity (AGI) and α-amylase inhibitory activity (AAI) of purified AMG alone or in combination with acarbose were then determined spectrophotometrically. The obtained results indicated that AMG had a purity of > 98% by HPLC examination and its chemical structure was confirmed by NMR spectra analysis combined with the reference. The isolated AMG showed good AGI and AAI with IC50 values of 8.25 µg/mL and 24.5 µg/mL, respectively. The AGI increased to 69.4% when AMG (5.0 µg/mL) was combined with acarbose at a concentration of 2.5 µg/mL, while the AAI did not have a clear synergistic effect. Our finding suggests the possibility of using the combination formula to enhance acarbose efficacy in treatment of the disease.
Isolation, selection and evaluation of α-glucosidase inhibitory activity from endophytic Streptomyces sp. isolated from Citrus myrtifolia cultivar in Hoa Binh, Vietnam
Authors: Thi Trung Nguyen , Thi Thao Nguyen , Hong Thao Phan Thi , Thanh Tuan Tran , Duy Nam Pham , Thanh Hoang Le , Tuyen Do Thi
Published: April 2023

Cao Phong orange (Citrus sinensis Lour) was grown in Cao Phong district, Hoa Binh province. Citrus sinensis is Vietnam’s most valued commercial fruit. In this study, 30 microorganim strains were isolated from the samples of root, stem, and leaf of Cao Phong orange. The ratio of endophytic actinomycetes was found in different parts of the plant: root, stem, and leaf was 37%, 40%, and 23%, respectively. The isolating HBC6-2 was selected because of its high output of α-glucosidase inhibitors from 6 different strains. Morphological, physiological, and biochemical characterization showed that HBC6-2 strain belongs to the Streptomyces sp. The 16S rRNA sequence of HBC6-2 indicated 99% identity to the corresponding sequence of Streptomyces costaricanus, and was registered on GenBank with the code MT 453944.1.

Streptomyces costaricanus EBL.HB6 was able to produce melanin yelow pigment, and its aerial and substrate mycelia have brown and yellow-grey pigment on ISP2, ISP3, ISP4, and ISP5 cultivating medium, respectively. The optimal pH range was from 5-10 and temperature from 15-40°C and exhibited salt tolerance up to 3% and utilized the carbon sources such as fructose, xylose, arabinose, cellulose, and rhamnose. In the following investigation, Streptomyces costaricanus EBL.HB6 displayed the highest α-glucosidase inhibitory activity by 68.98% among Streptomyces sp. strains
Förskjutningar i innehåll i SFO/Fritidshem i Skandinavien
Authors: Falkner Carin , Ludvigsson Ann , Öksnes Maria , Knutas Agneta , Kjaer Björg
Published: April 2023

Skolefritidsordning (SFO)/fritidshem har sitt ursprung i den nordiska modellen där utbildning ansågs vara en förutsättning för rättvisa, likvärdighet, social inkludering och demokratiskt deltagande. Den nordiska modellens enhetsskola kom i skymundan under 2000-talet i samband med konkurrensstatens och kunskapsskolans inträde med ett ökat fokus på nyttoorienterad kunskap, mätbara resultat och individuellt ansvar. Mot bakgrund av det vill vi genom en in- och utläsning undersöka, vilket innehåll som SFO/fritidshem i de tre skandinaviska länderna Danmark, Norge och Sverige tillskrivs via centrala styrdokument. Vår inläsning visar att SFO/fritidshem fått ett dubbelt uppdrag med motstridiga uppgifter; å ena sidan rekreation och lek och å andra lärande i riktning mot måluppfyllelse. Utläsningen visar att styrdokumentens innehåll har en slagsida åt det sistnämnda. Konkurrensstatens logik och kunskapsskolans dominans har ökat polariseringen i fritidshemmets uppdrag. Bärande element i den nordiska modellen kolonialiseras och blir till retorik för att legitimera konkurrensstatens logik.
Dynamics of Grain Yields in European Russia in the 19th — Early 20th Centuries: The Extent of Knowledge of the Issue
Authors:   Bryansk Branch of the G.V. Plekhanov Russian University of Economics, Bryansk, Sinitsyn Roman V.
Published: April 2023

This article deals with the problems of research in national science of the dynamics of grain yields in European Russia between the nineteenth and early twentieth centuries. For the purpose of the article, the author refers to crop statistics. Disputes about their reliability have been going on for about two hundred years, however, no irrefutable evidence of their unreliability has been presented. This is also true about the discussion of the early twenty-first century, where the source was criticised by B. N. Mironov and M. A. Davydov, and their opponents were S. A. Nefedov, A. V. Ostrovsky, and I. A. Kuznetsov. Interest in the dynamics of productivity emerged in the late nineteenth century. The focus of attention was the question of whether there was an increase in productivity in the period under review or not. At the turn of the twentieth century, A. F. Fortunatov and R. I. Preger maintained that productivity had increased, and I. Kh. Ozerov argued that it had not. In the 1920s, three views on the character of yield dynamics formed. V. G. Mikhailovsky and M. I. Semenov talked about a growth in yield combined with cyclical and random fluctuations. F. Cherevanin wrote that the yield in European Russia changed exclusively cyclically. V. M. Obukhov and A. L. Weinstein argued that grain yields grew, obscured by random fluctuations, in the absence of a cyclical component. It was the third point of view that prevailed with B. S. Yastremsky, A. S. Nifontov, A. V. Ostrovsky, V. G. Rastyannikov, and I. V. Deryugina following it. Only N. O. Voskresenskaya questioned the widespread increase in productivity. However, the previously used research methods (interval enlargement, correlation-regression analysis) are imperfect, and therefore the findings require rechecking using methods that are not in demand by national science for the analysis of crop statistics (hypothesis of the averages, Foster — Stewart method), which will help to better understand the nature grain yield dynamics in European Russia in the nineteenth and early twentieth centuries.
Realism as a Perpetual Challenge. Review of: Weisman, M., Vdovin, A., Klieger, I., & Ospovat, K. (Eds.). (2020). Russkii realizm XIX veka. Obshchestvo, znanie, povestvovanie [Russian Realism of the 19th Century. Society, Knowledge, Narrative]. Moscow: Novoe literaturnoe obozrenie. 568 p.
Authors:   Masaryk University, Brno, Czech Republic, Dohnal Josef ,   University of St. Cyril and Methodius in Trnava, Trnava, Slovak Republic
Published: April 2023

This text responds to the conceptualisation of nineteenth-century Russian realism presented in separate chapters of the monograph Russian Realism of the 19th Century. Society, Knowledge, Narrative. The review examines the objectives set in the introductory article of the collection and their development in specific studies. The review evaluates the tendency to actualise the work done so far in understanding the concept of “realism”, to pay attention to it again, and combine the views of Russian researchers with the works of foreign scholars. The authors of individual articles of the collection manage to direct their attention to the chosen aspects of studying not only of specific literary works of realist writers of the nineteenth century, but also to those factors external to their creative activities which in many respects determined the themes, subjects, and value orientation of their works. The review also points out that, while comprehending some specific features and specific literary works, and realism as a universal phenomenon, the authors often pay attention to rather private issues. Assessing the work done and the tendency to compare the works of Russian writers with Western ones, it is stated that the authors of individual chapters are not always able to summarise the results of the research and point out exactly what is universal in realism, and what is typical of the Russian realism of the nineteenth century.
Interação entre Educação Especial e Ensino Regular: ações pedagógicas a estudantes cegos
Authors: Mamcasz-Viginheski Lucia Virginia , Alvaristo Eliziane de Fátima , Shimazaki Elsa Midori
Published: April 2023

Resumo: Analisam-se ações pedagógicas realizadas no ensino de Matemática a estudantes cegos, a partir da interação entre a Educação Especial e o Ensino Regular. Trata-se de uma pesquisa qualitativa, do tipo descritivo-exploratória, de caráter documental. Fundamentada na Teoria Histórico-Cultural, se efetivou em um Centro de Atendimento Educacional Especializado na área da deficiência visual. Utilizaram-se para a coleta de dados fichas de registro e diálogos escritos e gravados em áudios, coletados entre os sujeitos participantes. Os resultados mostram: (a) as interações realizadas entre a Educação Especial e o Ensino Regular ampliam as ações de ensino e aprendizagem da Matemática aos estudantes com deficiência visual, já que articulam e complementam o trabalho entre ambas; (b) a interação e o estudo entre os professores permitem a aprendizagem e as mudanças conceituais sobre a deficiência e a possibilidade de aprendizagem dessas pessoas, a ampliar as pesquisas e os estudos sobre educação inclusiva.
EFEITOS DA AROMATERAPIA NOS SINTOMAS DE ANSIEDADE EM MULHERES COM CÂNCER DE MAMA: REVISÃO SISTEMÁTICA
Authors: Aragão Vivianne Melo , Lima Magda Milleyde de Sousa , Fernandes Cristina da Silva , Barros Lívia Moreira , Rodrigues Andrea Bezerra , Caetano Joselany Áfio
Published: April 2023

RESUMO Objetivo: avaliar o efeito da aromaterapia sobre os sintomas da ansiedade em mulheres sob tratamento para câncer de mama. Método: revisão sistemática, realizada a partir da estratégia PEOT: quais os efeitos da aromaterapia na redução dos sintomas da ansiedade em mulheres sob tratamento para o câncer de mama? A pesquisa foi realizada em seis bases de dados e em oito outras fontes de dados. Incluiu-se ensaios clínicos randomizados, sem restrição de data e idioma. Resultados: a amostra foi composta por sete estudos. A aromaterapia foi aplicada por inalação (57,1%) e massagem (42,8%), tendo sido adotada sozinha ou em conjunto a outras intervenções, demonstrando redução dos sintomas da ansiedade em 71,4% dos estudos. Ressalta-se o predomínio dos óleos essenciais de lavanda, bergamota, olíbano e sândalo, pelos seus efeitos ansiolíticos, relaxantes, sedativos, revigorantes, antidepressivos e redutores da tensão muscular. Conclusão: a aromaterapia apresentou resultados positivos e significativos na redução dos sintomas da ansiedade em mulheres em tratamento para câncer de mama.
Complex network effects on price setting: an agent-based computational approach
Authors: Feltrin Rafael Jasper , Almeida Helberte João França , Silveira Jaylson Jair da
Published: April 2023

Abstract We present an adaptation of a new Keynesian model into an agent-based computational model, accounting for the importance of heterogeneity, interaction and bounded rationality in problems such as price setting and expectations formation. We evaluate the evolution of the distribution of price setting strategy frequencies, which agents might choose on each period between inflationary, neutral or deflationary, a process based on private and social features of agents’ utility functions. In addition, we consider the network’s topological structure and find that the regular network model fails in replicating exactly the new Keynesian model’s original results, while the complex network model presents results in accordance with the originals.