bluuebunny/crossref_metadata_2025 huggingface dataset:
A Control Method to Balance the Efficiency and Reliability of a Time-Delayed Pump-Valve System
Authors: Lai Zhounian , Wu Peng , Yang Shuai , Wu Dazhuan
Published: September 2016

The efficiency and reliability of pumps are highly related to their operation conditions. The concept of the optimization pump operation conditions is to adjust the operation point of the pump to obtain higher reliability at the cost of lower system efficiency using a joint regulation of valve and frequency convertor. This paper realizes the control of the fluid conveying system based on the optimization results. The system is a nonlinear Multi-Input Multioutput (MIMO) system with time delays. In this paper, the time delays are separated from the system. The delay-free system is linearized using input-output linearization and controlled using a sliding mode method. A modified Smith predictor is used to compensate time delays of the system. The control strategy is validated to be effective on the test bench. The comparison of energy consumption and operation point deviation between conventional speed regulation and the new method is presented.
An Optimization Synchronization Algorithm for TDDM Signal
Authors: Liu Fang , Feng Yongxin
Published: September 2016

The time division data modulation (TDDM) mechanism is recommended to improve the communications quality and enhance the antijamming capability of the spread spectrum communication system, which will be used in the next generation global navigation satellite (GNSS) systems. According to the principle and the characteristics of TDDM signal, an optimization synchronization algorithm is proposed. In the new algorithm, the synchronization accuracy and environmental adaptability have been improved with the special local sequence structure, the multicorrelation processing, and the proportion threshold mechanism. Thus, the inversion estimation formula was established. The simulation results demonstrate that the new algorithm can eliminate the illegibility threat in the synchronization process and can adapt to a lower SNR. In addition, this algorithm is better than the traditional algorithms in terms of synchronization accuracy and adaptability.
Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease
Authors: Cao Lei-Fang , Peng Xiao-Yan , Huang Ya , Wang Bing , Zhou Feng-Ming , Cheng Ruo-Xiao , Chen Li-Hua , Luo Wei-Feng , Liu Tong
Published: September 2016

In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu). PD rats developed thermal and mechanical hypersensitivity at the 4th week after surgery. HPLC analysis showed that NE content, but not dopamine or 5-HT, significantly decreased in lumbar spinal cord in PD rats. Additional noradrenergic depletion by injection of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) aggravated pain hypersensitivity in PD rats. At the 5th week after injection of 6-OHDA, systemic treatment with pharmacological norepinephrine (NE) precursor droxidopa (L-DOPS) orα2 adrenoceptor agonist clonidine significantly attenuated thermal and mechanical pain hypersensitivity in PD rats. Furthermore, application of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) reuptake inhibitors duloxetine, but not 5-HT selective reuptake inhibitors sertraline, significantly inhibited thermal and mechanical pain hypersensitivity in PD rats. Systemic administration of Madopar (L-DOPA) or the D2/D3 agonist pramipexole slightly inhibited the thermal, but not mechanical, hypersensitivity in PD rats. Thus, our study revealed that impairment of descending noradrenergic system may play a key role in PD-associated pain and restoring spinal noradrenergic inhibitory tone may serve as a novel strategy to manage PD-associated pain.
Nanopatterning Gold by Templated Solid State Dewetting on the Silica Warp and Weft of Diatoms
Authors: Hiltz Jon , Hajiaboli Ahmadreza , Singh Gursimranbir , Lennox R. Bruce , Fussmann Gregor F. , Low-Decarie Etienne , Andrews Mark P.
Published: September 2016

The diatom,Nitzschia palea, exhibits complex silica shell (frustule) topography that resembles the warp and weft pattern of woven glass. The surface is perforated with a rhombic lattice of roughly oblong pores between periodically undulating transverse weft costae. Exfoliated frustules can be used to template gold nanoparticles by thermally induced dewetting of thin gold films. Acting as templates for the process, the frustules give rise to two coexisting hierarchies of particle sizes and patterned distributions of nanoparticles. By examining temperature dependent dewetting of 5, 10, and 15 nm Au films for various annealing times, we establish conditions for particle formation and patterning. The 5 nm film gives distributions of small particles randomly distributed over the surface and multiple particles at the rhombic lattice points in the pores. Thicker films yield larger faceted particles on the surface and particles that exhibit shapes that are roughly conformal with the shape of the pore container. The pores and costae are sources of curvature instabilities in the film that lead to mass transport of gold and selective accumulation in the weft valleys and pores. We suggest that, with respect to dewetting, the frustule comprises 2-dimensional sublattices of trapping sites. The pattern of dewetting is radically altered by interposing a self-assembled molecular adhesive of mercaptopropyltrimethoxysilane between the Au film overlayer and the frustule. By adjusting the interfacial energy in this manner, a fractal-like overlay of Au islands coexists with a periodic distribution of nanoparticles in the pores.
A Framework to Measure the Service Quality of Distributor with Fuzzy Graph Theoretic Approach
Authors: Gupta Tarun Kumar , Singh Vikram
Published: September 2016

A combination of fuzzy logic and graph theoretic approach has been used to find the service quality of distributor in a manufacturing supply chain management. This combination is termed as the fuzzy graph theoretic (FGT) approach. Initially the identified factors were grouped by SPSS (statistical package for social science) software and then the digraph approach was applied. The interaction and inheritance values were calculated by fuzzy graph theory approach in terms of permanent function. Then a single numerical index was calculated by using permanent function which indicates the distributor service quality. This method can be used to compare the service quality of different distributors.
Delayed Femoral Nerve Palsy Associated with Iliopsoas Hematoma after Primary Total Hip Arthroplasty
Authors: Kumar Sandeep , Pflueger Gerald
Published: September 2016

Femoral nerve neuropathy after total hip arthroplasty is rare but catastrophic complication. Pain and quadriceps muscle weakness caused by this complication can significantly affect the functional outcome. Here we present a case report, describing delayed onset femoral nerve palsy associated with iliopsoas hematoma following pseudoaneurysm of a branch of profunda femoris artery after 3 months of primary total hip arthroplasty in an 80-year-old female patient with single kidney. Hip arthroplasty was done for painful primary osteoarthritis of left hip. Diagnosis of femoral nerve palsy was made by clinical examination and computed tomography imaging of pelvis. Patient was managed by surgical evacuation of hematoma and physiotherapy. The patient’s clinical symptoms were improved after surgical evacuation of hematoma. This is the first case report of its kind in English literature regarding delayed onset femoral nerve palsy after primary total hip arthroplasty due to pseudoaneurysm of a branch of profunda femoris artery without any obvious precipitating factor.
Airway Management in a Patient with Wolf-Hirschhorn Syndrome
Authors: Gamble John F. , Kurian Dinesh J. , Udani Andrea G. , Greene Nathaniel H.
Published: September 2016

We present a case of a 3-month-old female with Wolf-Hirschhorn syndrome (WHS) undergoing general anesthesia for laparoscopic gastrostomy tube placement with a focus on airway management. WHS is a rare 4p microdeletion syndrome resulting in multiple congenital abnormalities, including craniofacial deformities. Microcephaly, micrognathia, and glossoptosis are common features in WHS patients and risk factors for a pediatric airway that is potentially difficult to intubate. We discuss anesthesia strategies for airway preparation and management in a WHS patient requiring general anesthesia with endotracheal intubation.
Determining the Optimal Duration of Progesterone Supplementation prior to Transfer of Cryopreserved Embryos and Its Impact on Implantation and Pregnancy Rates: A Pilot Study
Authors: Sharma Sangita , Majumdar Abha
Published: September 2016

Objective.To determine the optimal duration of progesterone supplementation prior to transfer of cryopreserved embryos and its impact on implantation and pregnancy rates.Study Design. Prospective randomised study.Materials and Methods. In an IVF unit of a tertiary centre, sixty-six patients undergoing cryopreserved embryo transfer cycles were included. Endometrial preparation was done with estradiol valerate. Once it reached a minimum of 7 mm, patients were allocated randomly into group I (n=39) and group II (n=27). Injectable progesterone 100 mg daily was then started for 3 and 4 days, respectively. This was followed by transfer of at least one thawed cleavage stage day 2 embryo of good quality. Groups I and II were compared in terms of clinical pregnancy and implantation rates.Results. In group I (3-day progesterone) and group II (4-day progesterone) the pregnancy rates were 41.02% (16/39) and 18.51% (5/27), respectively. On the other hand, the implantation rates were 16.82% (18/107) and 7.69% (6/78), respectively. The difference was statistically significant (pvalues 0.0172 and 0.0386, resp.).Conclusion. Progesterone supplementation for three days before the transfer of cleavage stage (day 2) cryopreserved embryos has significantly higher pregnancy and implantation rates, as compared to four-day supplementation.
Meralgia Paresthetica after Prone Positioning Ventilation in the Intensive Care Unit
Authors: Juhl Christian Svendsen , Ballegaard Martin , Bestle Morten H. , Tfelt-Hansen Peer
Published: September 2016

Meralgia paresthetica (MP) is a mononeuropathy of the lateral femoral cutaneous nerve (LFCN) caused by external compression of the nerve during its course close to the anterior superior iliac spine. We present a case of a patient with acute respiratory distress induced byLegionellapneumonia who was admitted to the intensive care unit (ICU) for mechanical ventilation. In the ICU, the patient received one session of prone position ventilation for 8.5 consecutive hours. At evaluation six months later, the patient reported persistent bilateral numbness of the anterolateral thigh, which he complained had begun right after he woke up at the ICU. He was referred for further neurological and neurophysiological examination and was diagnosed with bilateral MP, a condition never previously described as a complication to mechanical ventilation in prone position in the ICU.
Inhalation Conscious Sedation with Nitrous Oxide and Oxygen as Alternative to General Anesthesia in Precooperative, Fearful, and Disabled Pediatric Dental Patients: A Large Survey on 688 Working Sessions
Authors: Galeotti Angela , Garret Bernardin Annelyse , D’Antò Vincenzo , Ferrazzano Gianmaria Fabrizio , Gentile Tina , Viarani Valeria , Cassabgi Giorgio , Cantile Tiziana
Published: September 2016

Aim. To evaluate the effectiveness and the tolerability of the nitrous oxide sedation for dental treatment on a large pediatric sample constituting precooperative, fearful, and disabled patients.Methods. 472 noncooperating patients (aged 4 to 17) were treated under conscious sedation. The following data were calculated: average age; gender distribution; success/failure; adverse effects; number of treatments; kind of dental procedure undertaken; number of dental procedures for each working session; number of working sessions for each patient; differences between males and females and between healthy and disabled patients in relation to success; success in relation to age; and level of cooperation using Venham score.Results. 688 conscious sedations were carried out. The success was 86.3%. Adverse effects occurred in 2.5%. 1317 dental procedures were performed. In relation to the success, there was a statistically significant difference between healthy and disabled patients. Sex and age were not significant factors for the success. Venham score was higher at the first contact with the dentist than during the treatment.Conclusions. Inhalation conscious sedation represented an effective and safe method to obtain cooperation, even in very young patients, and it could reduce the number of pediatric patients referred to hospitals for general anesthesia.
Crosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability
Authors: Du Lijun , Kim John J. , Shen Jinhua , Dai Ning
Published: September 2016

The barrier function of the intestine is essential for maintaining the normal homeostasis of the gut and mucosal immune system. Abnormalities in intestinal barrier function expressed by increased intestinal permeability have long been observed in various gastrointestinal disorders such as Crohn’s disease (CD), ulcerative colitis (UC), celiac disease, and irritable bowel syndrome (IBS). Imbalance of metabolizing junction proteins and mucosal inflammation contributes to intestinal hyperpermeability. Emerging studies exploringin vitroandin vivomodel system demonstrate that Rho-associated coiled-coil containing protein kinase- (ROCK-) and myosin light chain kinase- (MLCK-) mediated pathways are involved in the regulation of intestinal permeability. With this perspective, we aim to summarize the current state of knowledge regarding the role of inflammation and ROCK-/MLCK-mediated pathways leading to intestinal hyperpermeability in gastrointestinal disorders. In the near future, it may be possible to specifically target these specific pathways to develop novel therapies for gastrointestinal disorders associated with increased gut permeability.
Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function
Authors: Stockburger Carola , Miano Davide , Pallas Thea , Friedland Kristina , Müller Walter E.
Published: September 2016

The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired neuroplasticity, and finally cell death as one major pathomechanism underlying the continuum from brain aging over mild cognitive impairment to initial and advanced late onset Alzheimer’s disease. Accordingly, improving mitochondrial function has become an important strategy to treat the early stages of this continuum. The metabolic enhancer piracetam has been proposed as possible prototype for those compounds by increasing impaired mitochondrial function and related aspects like mechanisms of neuroplasticity. We here report that piracetam at therapeutically relevant concentrations improves neuritogenesis in the human cell line SH-SY5Y over conditions mirroring the whole spectrum of age-associated cognitive decline. These effects go parallel with improvement of impaired mitochondrial dynamics shifting back fission and fusion balance to the energetically more favorable fusion site. Impaired fission and fusion balance can also be induced by a reduction of the mitochondrial permeability transition pore (mPTP) function as atractyloside which indicates the mPTP has similar effects on mitochondrial dynamics. These changes are also reduced by piracetam. These findings suggest the mPTP as an important target for the beneficial effects of piracetam on mitochondrial function.
The Effect of File Size and Type and Irrigation Solutions on the Accuracy of Electronic Apex Locators: AnIn VitroStudy on Canine Teeth
Authors: Janeczek Maciej , Kosior Piotr , Piesiak-Pańczyszyn Dagmara , Dudek Krzysztof , Chrószcz Aleksander , Czajczyńska-Waszkiewicz Agnieszka , Kowalczyk-Zając Małgorzata , Gabren-Syller Aleksandra , Kirstein Karol , Skalec Aleksandra , Bryła Ewelina , Dobrzyński Maciej
Published: September 2016

Measurements of the root canal during endodontic treatment have a significant influence on the course of the therapeutic process as well as on its final result in both human and veterinary medicine. The apical constriction should be the termination point for the preparation and filling of the root canal. This research was conducted with the use of a Septodont kit consisting of a small chamber filled with the examined solution in which a healthy second incisor was placed. The step back method was applied for the root canal preparation and master apical file of 30 was used. The working length was 22 mm. The examination was conducted with the use of steel as well as nickel titanium hand instruments. Different irrigation solutions and two types of apex locators were used. Measurements of the working length of the root canal showed dependence on the size of the instrument. Examinations carried out in various environments showed that analogical measurements were obtained only for sodium hypochlorite solutions. In other environments the measured sections were shortened. Comparative examinations with the use of steel instruments demonstrated insignificant measurement differences. Compared to these results, the measurements in nickel titanium group were characterized by more considerable deviations.
MRI‐Based Assessment of Intralesional Delivery of Bone Marrow‐Derived Mesenchymal Stem Cells in a Model of Equine Tendonitis
Authors: Scharf Alexandra , Holmes Shannon P. , Thoresen Merrilee , Mumaw Jennifer , Stumpf Alaina , Peroni John
Published: September 2016

Ultrasound‐guided intralesional injection of mesenchymal stem cells (MSCs) is held as the benchmark for cell delivery in tendonitis. The primary objective of this study was to investigate the immediate cell distribution following intralesional injection of MSCs. Unilateral superficial digital flexor tendon (SDFT) lesions were created in the forelimb of six horses and injected with 10 × 106 MSCs labeled with superparamagnetic iron oxide nanoparticles (SPIOs) under ultrasound guidance. Assays were performed to confirm that there were no significant changes in cell viability, proliferation, migration, or trilineage differentiation due to the presence of SPIOs. Limbs were imaged on a 1.5‐tesla clinical MRI scanner postmortem before and after injection to determine the extent of tendonitis and detect SPIO MSCs. Clusters of labeled cells were visible as signal voids in 6/6 subjects. Coalescing regions of signal void were diffusely present in the peritendinous tissues. Although previous reports have determined that local injury retains cells within a small radius of the site of injection, our study shows greater than expected delocalization and relatively few cells retained within collagenous tendon compared to surrounding fascia. Further work is needed if this is a reality in vivo and to determine if directed intralesional delivery of MSCs is as critical as presently thought.
Novel Use of Natural Language Processing (NLP) to Predict Suicidal Ideation and Psychiatric Symptoms in a Text-Based Mental Health Intervention in Madrid
Authors: Cook Benjamin L. , Progovac Ana M. , Chen Pei , Mullin Brian , Hou Sherry , Baca-Garcia Enrique
Published: September 2016

Natural language processing (NLP) and machine learning were used to predict suicidal ideation and heightened psychiatric symptoms among adults recently discharged from psychiatric inpatient or emergency room settings in Madrid, Spain. Participants responded to structured mental and physical health instruments at multiple follow-up points. Outcome variables of interest were suicidal ideation and psychiatric symptoms (GHQ-12). Predictor variables included structured items (e.g., relating to sleep and well-being) and responses to one unstructured question, “how do you feel today?” We compared NLP-based models using the unstructured question with logistic regression prediction models using structured data. The PPV, sensitivity, and specificity for NLP-based models of suicidal ideation were 0.61, 0.56, and 0.57, respectively, compared to 0.73, 0.76, and 0.62 of structured data-based models. The PPV, sensitivity, and specificity for NLP-based models of heightened psychiatric symptoms (GHQ-12 ≥ 4) were 0.56, 0.59, and 0.60, respectively, compared to 0.79, 0.79, and 0.85 in structured models. NLP-based models were able to generate relatively high predictive values based solely on responses to a simple general mood question. These models have promise for rapidly identifying persons at risk of suicide or psychological distress and could provide a low-cost screening alternative in settings where lengthy structured item surveys are not feasible.
Posttraumatic Skin and Soft-Tissue Infection due toPseudomonas fulva
Authors: Cobo Fernando , Jiménez Gemma , Rodríguez-Granger Javier , Sampedro Antonio
Published: September 2016

We report a case of posttraumatic skin and soft-tissue infection in a patient with a left thigh wound after a traffic accident.Pseudomonas fulvawas isolated from a wound aspirate and was identified to the species level by Maldi-tof. The patient responded to drainage, debridement of wound, and two weeks of intravenous antibiotic therapy. Follow-up after 3 weeks was satisfactory with healthy cover of the injured area.
Stability for a New Class of GNOVI with (γG,λ)-Weak-GRD Mappings in Positive Hilbert Spaces
Authors: Li Hong Gang , Yang Yongqin , Jin Mao Ming , Zhang Qinghua
Published: September 2016

By using ordered fixed point theory, we set up a new class of GNOVI structures (general nonlinear ordered variational inclusions) with(γG,λ)-weak-GRD mappings, discuss an existence theorem of solution, consider a perturbed Ishikawa iterative algorithm and the convergence of iterative sequences generated by the algorithm, and show the stability of algorithm for GNOVI structures in positive Hilbert spaces. The results in the instrument are obtained.
MRI Biomarkers for Hand-Motor Outcome Prediction and Therapy Monitoring following Stroke
Authors: Horn U. , Grothe M. , Lotze M.
Published: September 2016

Several biomarkers have been identified which enable a considerable prediction of hand-motor outcome after cerebral damage already in the subacute stage after stroke. We here review the value of MRI biomarkers in the evaluation of corticospinal integrity and functional recruitment of motor resources. Many of the functional imaging parameters are not feasible early after stroke or for patients with high impairment and low compliance. Whereas functional connectivity parameters have demonstrated varying results on their predictive value for hand-motor outcome, corticospinal integrity evaluation using structural imaging showed robust and high predictive power for patients with different levels of impairment. Although this is indicative of an overall higher value of structural imaging for prediction, we suggest that this variation be explained by structure and function relationships. To gain more insight into the recovering brain, not only one biomarker is needed. We rather argue for a combination of different measures in an algorithm to classify fine-graded subgroups of patients. Approaches to determining biomarkers have to take into account the established markers to provide further information on certain subgroups. Assessing the best therapy approaches for individual patients will become more feasible as these subgroups become specified in more detail. This procedure will help to considerably save resources and optimize neurorehabilitative therapy.
Iron Deficiency Impairs Developing Hippocampal Neuron Gene Expression, Energy Metabolism, and Dendrite Complexity
Authors: Bastian Thomas W. , von Hohenberg William C. , Mickelson Daniel J. , Lanier Lorene M. , Georgieff Michael K.
Published: September 2016

Iron deficiency (ID), with and without anemia, affects an estimated 2 billion people worldwide. ID is particularly deleterious during early-life brain development, leading to long-term neurological impairments including deficits in hippocampus-mediated learning and memory. Neonatal rats with fetal/neonatal ID anemia (IDA) have shorter hippocampal CA1 apical dendrites with disorganized branching. ID-induced dendritic structural abnormalities persist into adulthood despite normalization of the iron status. However, the specific developmental effects of neuronal iron loss on hippocampal neuron dendrite growth and branching are unknown. Embryonic hippocampal neuron cultures were chronically treated with deferoxamine (DFO, an iron chelator) beginning at 3 days in vitro (DIV). Levels of mRNA for Tfr1 and Slc11a2, iron-responsive genes involved in iron uptake, were significantly elevated in DFO-treated cultures at 11DIV and 18DIV, indicating a degree of neuronal ID similar to that seen in rodent ID models. DFO treatment decreased mRNA levels for genes indexing dendritic and synaptic development (i.e. BdnfVI,Camk2a,Vamp1,Psd95,Cfl1, Pfn1,Pfn2, and Gda) and mitochondrial function (i.e. Ucp2,Pink1, and Cox6a1). At 18DIV, DFO reduced key aspects of energy metabolism including basal respiration, maximal respiration, spare respiratory capacity, ATP production, and glycolytic rate, capacity, and reserve. Sholl analysis revealed a significant decrease in distal dendritic complexity in DFO-treated neurons at both 11DIV and 18DIV. At 11DIV, the length of primary dendrites and the number and length of branches in DFO-treated neurons were reduced. By 18DIV, partial recovery of the dendritic branch number in DFO-treated neurons was counteracted by a significant reduction in the number and length of primary dendrites and the length of branches. Our findings suggest that early neuronal iron loss, at least partially driven through altered mitochondrial function and neuronal energy metabolism, is responsible for the effects of fetal/neonatal ID and IDA on hippocampal neuron dendritic and synaptic maturation. Impairments in these neurodevelopmental processes likely underlie the negative impact of early life ID and IDA on hippocampus-mediated learning and memory.
Venous Thromboembolism in Primary Nephrotic Syndrome - Is the Risk High Enough to Justify Prophylactic Anticoagulation?
Authors: Rankin Alastair J. , McQuarrie Emily P. , Fox Jonathan G. , Geddes Colin C. , MacKinnon Bruce ,   on behalf of the Scottish Renal Biopsy Registry
Published: September 2016

Background: The reported incidence of venous thromboembolism (VTE) in patients with nephrotic syndrome (NS) varies widely, as does the approach to prophylactic anticoagulation. We aimed to assess the incidence of VTE in patients with primary NS in order to inform a sample size calculation to determine if a future clinical trial will ever be feasible. Methods: All adults undergoing native renal biopsy for NS between 2008 and 2013 yielding a diagnosis of primary glomerulonephritis were identified. Baseline serum albumin, urine protein:creatinine ratio, estimated glomerular filtration rate, date of biopsy and histological diagnosis were recorded. Episodes of objectively verified VTE were identified using the electronic patient record. Sample size calculations were performed based on 2 independent samples with a dichotomous outcome and to achieve a power of 80% and p < 0.05. Results: Two hundred six patients were included of which 60% were male and mean age at biopsy was 55 years (SD 19). Median follow-up was 2.9 years (interquartile range (IQR) 1.6-4.7). Fourteen (6.8%) patients suffered VTE. Median time to diagnosis of VTE from renal biopsy was 36 days (IQR -22 to 178), with 6 VTEs occurring prior to biopsy and 1 during remission. In a total of 270 patient years of NS, there were 7 VTE that could potentially have been avoided if anticoagulation was given for the duration of NS, that is, 2.6% risk per year of NS; this risk was highest for patients with minimal change nephropathy at 13.3% per year of NS, compared to 0.65% per year of NS for those with idiopathic membranous nephropathy. Assuming a 75% reduction in the incidence of VTE with prophylactic anticoagulation, 972 participants would be required for a future clinical trial to have 80% power. Conclusions: Patients with primary NS are at an increased risk of VTE. The timing of VTE means that only half of episodes would be targeted by prophylactic anticoagulation. Given the low frequency of events, a well-powered clinical trial would be challenging to achieve.
Long-Term Management of Complications of Retinal Artery Macroaneurysms with Intravitreal Aflibercept Injection
Authors: Kishore Kamal
Published: September 2016

Purpose: To report the 1-year follow-up results of intravitreal aflibercept injection (IAI) for the management of complications of retinal artery macroaneurysms (RAM). Methods: A retrospective, noncomparative, interventional case series of 4 eyes of 4 patients (all female, aged 68–91 years, 3 treatment naive) treated with IAI 2 mg for complications of RAM [macular edema (ME) 2, submacular hemorrhage (SMH) 1, and vitreous hemorrhage (VH) 1] was conducted. Baseline parameters consisted of complete ocular examination, medical history, best-corrected Snellen VA, fundus photography, IVFA and SD OCT, unless precluded by VH (1). All patients completed ≥1 year follow-up. Results: Baseline VA was hand motions in the eye with SMH (31 mm2 area and 1,478 μm thickness); 20/40 and 20/100 with ME (CST 390 and 337 μm, respectively), and 20/200 in the eye with VH. At 1 month, both patients with ME showed resolution of ME with CST <300 μm with improvement in VA which was maintained through 1 year. VH resolved in one eye at 1 month with no recurrence after 1 year. The eye with SMH developed macular scar and had counting fingers vision at 1 year. Thrombosis of RAM was noted in all eyes and hairpin-like remodeling of artery in one. No eye required repeat injection or laser. Conclusion: ME and VH from RAM were effectively treated with IAI. However, the eye with thick SMH had poor visual outcome despite thrombosis of RAM. Single IAI provided effective therapy for complications of RAM with excellent anatomical and visual results in each eye, except one with thick SMH, and merits further study.
The Effect of Spinal Tap Test on Different Sensory Modalities of Postural Stability in Idiopathic Normal Pressure Hydrocephalus
Authors: Abram Katrin , Bohne Silvia , Bublak Peter , Karvouniari Panagiota , Klingner Carsten M. , Witte Otto W. , Guntinas-Lichius Orlando , Axer Hubertus
Published: September 2016

Background/Aims: Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. Methods: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test. Results: The gait score showed a significant improvement 24 h after spinal tap test in all subtests and in the sum score (p < 0.003), while neuropsychological assessment did not reveal significant differences 72 h after spinal tap test. CDP showed significant improvements after spinal tap test in the Sensory Organization Tests 2 (p = 0.017), 4 (p = 0.001), and 5 (p = 0.009) and the composite score (p = 0.01). Patients showed best performance in somatosensory and worst performance in vestibular dominated tests. Vestibular dominated tests did not improve significantly after spinal tap test, while somatosensory and visual dominated tests did. Conclusion: Postural stability in NPH is predominantly affected by deficient vestibular functions, which did not improve after spinal tap test. Conditions which improved best were mainly independent from visual control and are based on proprioceptive functions.
Ficção e história: o espelho transparente de Machado de Assis
Authors: Roncari Luiz
Published: September 2016

Segundo Luiz Roncari, a partir da leitura da obra de Edgar Allan Poe, Machado de Assis teria aprendido um método de investigação e exposição que lhe permitiu criar novas formas de estruturação narrativa. Através da análise do conto “Singular ocorrência", o autor demonstra como as teorias de Poe adquirem forma narrativa em Machado num jogo de ocultação e revelação
Visionarismo satânico no poema em prosa de Cruz e Sousa: trabalho poético e marginalidade
Authors: Rufinoni Simone Rossinetti
Published: September 2016

A partir da abordagem de alguns poemas em prosa de Cruz e Sousa, a autora aponta os dramas e os antagonismos vividos por um poeta negro, atormentado pelo preconceito num país escravista. “Assinalado" pelo trabalho poético, Cruz e Sousa encarna satanícamente o discurso e os valores da época, como um visionário que contempla sua inevitável condição
A dois passos do deserto: visões urbanas de Euclides na Amazônia
Authors: Hatoum Milton
Published: September 2016

Através de algumas cartas de Euclides da Cunha tomamos conhecimento do seu olhar inquieto e urbano sobre a ‘‘emblemática’' Amazônia. O fascínio e a aversão do escritor pela alteridade da região contribuem para uma escrita de tensão e miragem associada às impressões de modernidade, sugeridas pelas cidades de Belém e Manaus
Jardins modernistas
Authors: Carvalho Ricardo Souza de
Published: September 2016

Uma das facetas da urbanização brasileira nas primeiras décadas do século xx foi a criação ou reforma de jardins a partir de modelos europeus. A literatura tematiza o belo jardim estrangeiro, contrapondo-o a uma paisagem nacional. Este ensaio analisa os poemas “Anhangabaú” de Mário de Andrade e Jardim da praça da Liberdade” de Carlos Drummond de Andrade, comparando os processos de modernização literária em São Paulo e Belo Horizonte
Carta de Idelfonso Pereda Valdés para Jorge de Lima
Authors: Valdés Ildefonso Pereda
Published: September 2016

Sobre os poemas de Jorge de Lima
Mário , Jorge
Authors: Moraes Marcos Antonio De
Published: September 2016

Mário, Jorge” busca reconstituir a amizade entre os escritores Mário de Andrade (1893-1945) e Jorge de Lima (1893- 1953). As afinidades artísticas e a admiração mútua são documentadas por meio de artigos jornalísticos, dedicatórias em livros, manuscritos literários, fotografias e correspondência pertencentes ao Arquivo Mário de Andrade do Instituto de Estudos Brasileiros da Universidade de São Paulo
A resistência do olhar: uma leitura do poema "Balõezinhos" de Manuel Bandeira
Authors: Teixeira César Mota
Published: September 2016

O autor analisa e interpreta o poema “ Balõezinhos”, de Manuel Bandeira, buscando identificar, por trás da simplicidade e do despojamento formal, as fraturas e os contrastes que alicerçam a unidade verdadeiramente paradoxal e dramática do texto
Afigura da grade
Authors: Falleiros Marcos Falchero
Published: September 2016

O conflito entre sujeito e m undo em Graciliano Ram os aparece na figura da grade: seleção e com binação, claro e escuro, categórico e impressionável, linguagem de fotogram a e sistem atização marxista
Chico Buarque e a ótica do movimento
Authors: Mancini Renata
Published: September 2016

O presente trabalho sustenta que a precisão e a maestria de Chico Buarque em traduzir a essência da cultura brasileira são tributárias da incorporação do movimento ao cerne de sua obra. Para isso, mostra como o autor cria mundos ambivalentes, refratários a delimitações e, portanto, dependentes de um movimento pendular contínuo entre seus pólos constitutivos. Partindo das análises da canção “ Homenagem ao Malandro” e do romance Estorvo, procura explicitar como Chico extrapola a ordem do senso comum ao explorar as diferentes maneiras de construir mundos ambivalentes baseados em lógicas opostas, uma construída a partir da co-presença e outra a partir da co-ausência de pólos extremos
A voz: entre a palavra e a melodia
Authors: Carmo Junior José Roberto Do
Published: September 2016

O delicado equilíbrio entre verbo e música que se manifesta na canção popular está intimamente ligado à dupla natureza da voz humana, instrumento de fala e instrumento de música a um tempo. O autor propõe que uma revisitação às teorias formalistas da linguagem, sobretudo à glossemática de Hjelmslev, poderia iluminar esse jogo de parentescos, afinidades e encontros entre a música e o verbo. Disso se valeria uma teoria crítica da canção, especialmente da canção popular, certamente uma das mais ricas e instigantes realizações desse encontro
O avesso do folclore: musicalidade urbana e pensamento musical nos anos 20
Authors: Teixeira Maurício De Carvalho
Published: September 2016

Este ensaio trata do impacto da industrialização da música nos meios letrados, durante a década de 20, buscando associar as transformações das manifestações populares com uma crescente defesa do folclore. Esta relação conduz a uma abordagem particular da literatura musical de Mário de Andrade, mostrando sua relação com esse contexto
A canção de Siruiz/Ziuris
Authors: Roncari Luiz
Published: September 2016

O estudo pretende mostrar como a canção de Siruiz tematiza o problema da formação do herói em Grande sertão: veredas, de Guimarães Rosa, e como, para ser bem compreendida, precisa ser circunstanciada nos diferentes momentos em que é lembrada. Quando Riobaldo chega ao meio do caminho da sua vida, na vila do Urubu, como metáfora paródica da metáfora “selva oscura” — como Dante, na Divina Comédia — ele começa a tomar consciência de si e do que a canção que o inquietava tanto de fato lhe dizia
Querer, poder, precisar: "O caso da vara"
Authors: Villaça Alcides
Published: September 2016

No aparente acanhamento de uma cena doméstica, em que as necessidades, os desejos e os caprichos das personagens tecem uma trama a princípio farsesca, urdida no interior do nosso conhecido sistema de compadrio e apadrinhamento, o narrador machadiano vai pondo a nu o motivo real de cada uma das ações, empreendendo uma fulminante análise tanto dos impulsos subjetivos das personagens como da violência da sociedade escravista.
De pontos, linhas e fugas: três "contos de formação" machadianos
Authors: Paz Ravel Giordano
Published: September 2016

O trabalho propõe uma “costura possível” de três contos de Machado de Assis nos quais o aprendizado é um tema central, esboçando um hipotético “processo de form ação de uma figura autoral machadiana. E sublinha, no desenho geral dessa figura”, alguns traços muitas vezes relevados na fortuna crítica do autor
A emenda de Séneca - Machado de Assis e a forma do conto
Authors: Baptista Abel Barros
Published: September 2016

Partindo do conto “O empréstimo” de Papéis avulsos, o ensaio analisa a forma do conto machadiano na relação com o problema da interpretação: a forma breve é delimitada pela resolução — sempre provisória, aliás precária — da interpretação dum momento, dum acontecimento, duma cena ou dum episódio, que por sua vez remetem para uma globalidade por via dessa mesma interpreta­ ção. Nessa resolução, desempenha papel decisivo a figura da autoridade do narrador, que o ensaio analisa em três exemplos: “O espelho”, “ Primas de Sapucaia” e “A causa secreta”.
Que reino e esse?
Authors: Moraes Eugênio Vinci de
Published: September 2016

Com este artigo quer se mostrar de que forma Machado de Assis “traduz” para seu sistema literário as fontes estrangeiras, em particular no conto “As academias de Sião”. No caso a fonte é O príncipe, de Maquiavel, que, embora não aludido diretamente, serve de referência nuclear para essa história, a qual, em última instância, pode ser vista como uma fábula a respeito da natureza do poder
Machado de Assis e José Veríssimo: aspectos da correspondência entre o escritor e o crítico
Authors: Boaventura Cristiana Tiradentes
Published: September 2016

O artigo percorre as trocas epistolares entre Machado de Assis e José Veríssimo acentuando os laços entre escritor e crítico. As cartas evidenciam o estímulo ao trabalho críticoliterário de ambos e a estreita ligação literária que os uniu
D. Quixote e o Padeiro-mor: cartas de Monteiro Lobato a Antônio Sales
Authors: Tin Emerson
Published: September 2016

O objetivo deste artigo é analisar a correspondência entre Monteiro Lobato e Antônio Sales, com ênfase nas iniciativas editoriais de Lobato, sobretudo em relação à pretensão de re-editar o romance Dona Guidinha do poço, de Manuel de Oliveira Paiva
Mário de Andrade e Monteiro Lobato: um diálogo modernista em três tempos
Authors: Lajolo Marisa
Published: September 2016

Através de correspondência trocada entre M onteiro Lobato (1882-1948) e Mário de Andrade (1893-1945), o artigo discute diferentes aspectos da cena literária brasileira da primeira metade do século xx
Amizade em mosaico: a correspondência de Oswald a Mário de Andrade
Authors: Andrade Gênese
Published: September 2016

Neste ensaio, focaliza-se a amizade entre os dois modernistas, a partir da correspondência enviada por Oswald de Andrade a Mário de Andrade de 1919 a 1928
Cartas provincianas: Gilberto Freyre e Manuel Bandeira em crônica epistolar
Authors: Vicente Silvana Moreli
Published: September 2016

Gilberto Freyre e Manuel Bandeira começaram a trocar cartas em 1925. A leitura do conjunto lança luz sobre o estilo de escrita de ambos, além de ajudar a compor um quadro com elementos fundamentais para se compreender a dinâmica do Modernismo no Brasil. Recife e Rio de Janeiro são os espaços em que desfilam personagens e episódios contados nas linhas dessas “crônicas epistolares”
O reino deste Mundo: o Padroado e seus reflexos nas cartas de José de Anchieta
Authors: Navarro Eduardo De Almeida
Published: September 2016

Por meio da análise de algumas cartas de José de Anchieta, mostramos como a ação missionária jesuítica no século xvi não tinha quase nenhum espírito profético, estando submissa ao Estado, gerido por um rei-patrono
Para ler as cartas do Pe. Antônio Vieira (1626-1697)
Authors: Hansen João Adolfo
Published: September 2016

As cartas do Pe. Antônio Vieira, escritas ou ditadas em diversos lugares da América Portuguesa e da Europa entre 1626 e 1697, não são veículos neutros para sua matéria empírica, mas produtos simbólicos de uma prática escriturária integrada à “política católica” portuguesa e romana. Subordinando-se a regras da Companhia de Jesus e a interesses da Coroa portuguesa, põem em cena uma interpretação situada de suas matérias, desempenhando diversas funções em seu tempo, segundo os dois gêneros da ars dictaminis, familiar e negociai. O ensaio especifica as categorias metafísicas, teológicopolíticas e retóricas que ordenam e interpretam suas matérias
Literatura, ética e política em Sartre
Authors: Silva Franklin Leopoldo e
Published: September 2016

Em Que é a literatura? Sartre descreve o perfil da sua gera­ ção e fala do choque de história sofrido por ele e seus contemporâ­ neos. Aí, a história somente existe na medida em que o homem a faz fazendo-se ser histórico, o que implica tanto as determinações objetivas que nos constituem quanto a possibilidade de negá-las e superá-las pela liberdade. Assim, a história é sempre de todos e de cada um; do gênero humano e de cada homem; de uma sociedade e de cada indivíduo que a constitui; de uma época e de cada sujeito que a vive; de tal modo que a universalidade somente existe na diverP sidade da expressão singular e a singularidade só faz sentido a partir do lastro de universalidade que a constitui
Poesia auto-móvel
Authors: Bosi Viviana
Published: September 2016

Este texto comenta poemas que tratam do tema do automóvel de várias maneiras, tendo em vista uma possível alteração do olhar do poeta na cidade contemporânea. Os meios de transporte podem ser metáforas da vida na metrópole atual, simbolizando aspectos das experiências fugazes que o poeta configura como testemunho
Acumulação e desestabilização da forma na narrativa brasileira atual
Authors: Hossne Andrea Saad
Published: September 2016

Na literatura do fim do século XX e início do XXI, observa-se, em geral, uma produção de textos avessos a classificações e pouco adequados às categorias formais pertencentes à tradição. Diante de O flu xo silencioso das máquinas, de Bruno Zeni, Curva de rio sujo, de Joca Reiners Terron, e Eles eram muitos cavalos, de Luiz Ruffato, o crítico se vê às voltas com o problema da definição do gênero a que se filiam. Classificar ou não essas obras é uma dificuldade bem menos importante que o dilema que elas formalizam ou encenam: a de estabelecer relações, conferir sentido, ter, senão a totalidade, ao menos o impulso de buscá-la
A lucidez tardia: a poesia de Paulo Henriques Britto
Authors: Silva Arlenice Almeida da
Published: September 2016

O artigo examina a obra poética de Paulo Henriques Britto, em particular o livro Macau, de 2003, buscando situá-la no cenário poético contemporâneo. A partir de categorias estéticas de Adorno e do jovem Lukács, dos conceitos de moderno, ironia e autonomia da obra de arte e do diagnóstico da crise da poesia, procura-se entender como o poeta dialoga com a tradição em uma forma singular que combina elementos tradicionais, como o soneto, com a informalidade coloquial. Tal dicção que parte dos paradoxos da modernidade acaba tensionando a contemporaneidade ao procurar, entre outras coisas, encurtar a distância estética entre o autor e o leitor
Artes da conspiração: figurações do intelectual em Um crime delicado de Sérgio Sant'Anna
Authors: Mello Jefferson Agostini
Published: September 2016

A proposta deste artigo é discutir, a partir da leitura do romance Um crime delicado, de Sérgio Sant'Anna, as formas de representação do intelectual da cultura no contexto de uma sociedade de consumo. Por meio da análise da posição do narrador-personagem e da forma dissimulada através da qual aborda a matéria trabalhada no romance, tenciona-se demonstrar as articulações entre um novo esteticismo, a forma literária e a sociedade contemporânea
Hermanos e irmãos: As relações literárias entre os românticos argentinos e brasileiros durante o romantismo
Authors: Moreira Maria Eunice
Published: September 2016

O texto analisa a troca de ideias entre escritores românticos do Brasil e da Argentina sobre a nascente história da literatura nos dois países. Tanto os argentinos conheceram os textos dos brasileiros quanto estes leram a produção dos hermanos, sobretudo no período em que a Argentina vivia sob o domínio da ditadura de Rosas, e o Brasil vivenciava os tempos áureos do Segundo Reinado.
Teatro romântico e escravidão
Authors: Faria João Roberto
Published: September 2016

Como o teatro brasileiro dos tempos românticos representou o negro e a escravidão nos palcos e nos textos dramáticos? O artigo tenta dar uma resposta a essa questão – passando em revista as principais obras e autores que a abordaram –, a partir de uma sugestão colhida em texto de Brito Broca, para quem a literatura brasileira fez abolicionismo romântico e realista.
Projetos para uma pátria imaginada: o Brasil de José Bonifácio e Hipólito da Costa
Authors: Lustosa Isabel
Published: September 2016

Antes mesmo da Independência, a ideia de um Brasil unido e coeso em torno de um centro político existia como um ideal romântico na mente de alguns brasileiros. Mas havia uma dissonância entre aqueles que, olhando de dentro, viam o Brasil como a sua pátria, região ou localidade em que nasceram; e outros que, educados na Europa,construíram seu imaginário em torno das imensas, reais ou idealizadas, potencialidades do Brasil unido do Oiapoque ao Chuí.
A comédia urbana: de Robert Macaire à Lanterna Mágica. Representações e práticas comparáveis na imprensa ilustrada no século XIX - entre o romantismo e o realismo
Authors: Angotti-Salgueiro Heliana
Published: September 2016

Estudo comparativo entre a série de caricaturas de Honoré Daumier, “Les Robert Macaire”, e as do folhetim A Lanterna Mágica, atribuídas a Manuel de A. Porto-Alegre. A apropriação evidencia-se na forma e no sentido da crítica dos costumes, da política, da corrupção e das situações cotidianas, temas atemporais, de significativa atualidade.