bluuebunny/crossref_metadata_2025 huggingface dataset:
Deskripsi Pemecahan Masalah Matematika berdasarkan Langkah Polya ditinjau dari Kepribadian Siswa Tipe Melankolis
Authors: Razak Firdha , Sutrisno Ahmad Budi , Kamaruddin Rahmat
Published: January 2019

This research is a qualitative research aimed to disclose math problem-solving ability based on Polya steps on SPLDV’s material  in term of student personalities melancholy (ME). Instruments used for this research are : 1) personality test is used  to categorize the students based on their personality, 2) math problem-solving test is used to show  students' ability in solving mathematical problems based on Polya steps, and 3) guided interview is contained guidelines aim to clarify answers and trace the process of students’ thought in depth. Data are collected by test and interview  and analyzed by using Miles and Huberman’s data analysis. The research processes are: (a) formulated the indicators based on math problem-solving on Polya steps (b) formulated a valid and reliable instrument (personality test, math problem-solving task and guided interview) (c) collected the subject by providing personality type, (d) collected data to show the description of math problem-solving is done by the students, (e) did time triangulation to get valid data, (f) performed data analysis problem-solving based on personality types, (g) conducted a discussion of the results of analysis, (h) drew conclusions of the research. The results showed the subject of melancholy did the Polya steps in problem-solving, which are (1) understand the problem (2) plan a settlement (3) settle a plan (4) check back.
Pengaruh Pendekatan Multiple Intelligences Terhadap Kemampuan Pemecahan Masalah Fisika Siswa
Authors: Asriani Rabiatul , Hikmawati Hikmawati , Wahyudi Wahyudi
Published: January 2019

This study is aimed to investigate the effect of multiple intelligences approach through the problem-based learning model (PBL) on the physics problem-solving abilities (PSA) of the tenth grade students. This study is an experimental research with a non-equivalent control group design. The sample was obtained through a purposive sampling technique, so the X-science 1 class was chosen as the experimental class and X-science 3 class as the control group. The experimental class was treated with a multiple intelligences approach through the PBL model, while the control class was given a conventional learning. Before being treated, the experimental class sample was given a multiple intelligence talent test questionnaire to find out the dominant intelligence in the class, after which the two samples were given a pre-test to find out their initial abilities. The results of the initial PSA test obtained an average experimental class value of 11.61 and a control class of 9.23. The homogeneity test results of the initial tests of the two samples had the same initial ability. The results of the PSA final test obtained were an average experimental class value of 72.32 and a control class of 60.62. The research hypothesis was tested by polled variance t-test with a significance level of 5%. Based on the results of the analysis, the value of tcount is greater than ttable, that is 11.9 > 1.99, so it can be concluded that there is an effect of multiple intelligences approach through PBL models on students’ physics problem solving.
Pengembangan Perangkat Pembelajaran Fisika Menggunakan Model Siklus Belajar 5E untuk Melatihkan Kemampuan Berpikir Kritis
Authors: Armansyah Armansyah , Ibrahim Muslimin , Wasis Wasis
Published: January 2019

The objective of this reaserch was to produce physics learning materials with learning cycles (5E) model which focuced on the validity, practically, and effectiveness to facilitate student’s critical thinking ability in calor matter. The learning tools development using 4D (define, design, develop, and disseminate)  development model and have been tested on second semester students of physics education, The Science Teacher Training Institute of Mataram. This trial development of research using one group Pre-test Post-test Design. Data collection methods used were validation paper questionnaires, tests and observation, whereas data analysis techniques using qualitative and quantitative descriptive method. Based on the assessment the validator has a valid criteria, showing several findings, namely, 1) the devices at the implementation stage, devices are developed have  practical criteria, which are measured by the implementation of the criteria learning “well done” and the response of students are “strong” 2) the effective developed  to train critical thinking ability, where there is an increase in students, critical thinking ability from the initial test on 62 to 90 in the final test. The result of the study generally show that physics learning devices use a valid, practical, and effective, and 5E learning cycle model to train students critical thingking ability.
Patient and primary care delays in the diagnostic pathway of gynaecological cancers: a systematic review of influencing factors
Authors: Williams Pauline , Murchie Peter , Bond Christine
Published: January 2019

Background

Gynaecological cancers are the second most common female cancer type, with survival rates in the UK lower than in many comparable countries. A potentially important factor in the UK’s poorer cancer outcomes is diagnostic delay; gynaecological cancers are the cancer type most likely to be affected by less timely diagnosis.

Aim

To examine current evidence for factors that contribute to patient and primary care delays in the diagnostic pathway of gynaecological cancer.

Design and setting

A systematic review of the available literature.

Method

PRISMA guidelines were followed. MEDLINE and Embase databases and the Cochrane Library were searched using three terms: primary care; gynaecological cancer; and delay. Citation lists of all identified articles were searched. Two authors independently screened the titles, abstracts, and full texts of publications. Data extraction was performed by one author and quality assured by a second reviewer in a 20% sample of selected articles. Synthesis was narrative.

Results

A total of 1253 references was identified, of which 37 met the inclusion criteria. Factors associated with delayed diagnosis were categorised as either patient factors (patient demographics, symptoms or knowledge, and presentation to the GP) or primary care factors (doctor factors: patient demographics, symptoms or knowledge, and referral process); and system factors (such as limited access to investigations).

Conclusion

Delayed diagnosis in the patient and primary care intervals of the diagnostic journey of gynaecological cancer is complex and multifactorial. This review identifies areas of future research that could lead to interventions to enable prompter diagnosis of gynaecological cancers.
Continuity of care in general practice at cancer diagnosis (COOC-GP study): a national cohort study of 2853 patients
Authors: Hurtaud Aline , Aubin Michèle , Ferrat Emilie , Lebreton Julien , Paillaud Elena , Audureau Etienne , Bastuji-Garin Sylvie , Chouaid Christos , Boisnault Philippe , Clerc Pascal , Canouï-Poitrine Florence
Published: January 2019

Background

At cancer diagnosis, it is unclear whether continuity of care (COC) between the patient and GP is safeguarded.

Aim

To identify patient–GP loss of COC around the time of, and in the year after, a cancer diagnosis, together with its determinants.

Design and setting

A post-hoc analysis of data from a prospective cohort of GPs in France, taken from a survey by the Observatoire de la Médecine Générale.

Method

A prospective GP cohort (n = 96) filed data on patients who were diagnosed with incident cancer between 1 January 2000 and 31 December 2010. COC was assessed by ascertaining the frequency of consultations and the maximal interval between them. (In France, patients see their referring/named GP in most cases.) A loss of COC was measured during the trimester before and the year after the cancer diagnosis, and the results compared with those from a 1-year baseline period before cancer had been diagnosed. A loss of COC was defined as a longer interval (that is, the maximum number of days) between consultations in the measurement periods than at baseline. Determinants of the loss in COC were assessed with univariate and multivariate logistic regression models.

Results

In total, 2853 patients were included; the mean age was 66.1 years. Of these, 1440 (50.5%) were women, 389 (13.6%) had metastatic cancer, and 769 (27.0%) had a comorbidity. The mean number of consultations increased up to, and including, the first trimester after diagnosis. Overall, 26.9% (95% confidence interval [CI] = 25.3 to 28.6) of patients had a loss of COC in the trimester before the diagnosis, and 22.3% (95% CI = 20.7 to 23.9) in the year after. Increasing comorbidity score was independently associated with a reduction in the loss of COC during the year after diagnosis (adjusted odds ratio [OR] comorbidity versus no comorbidity 0.61, 95% CI = 0.48 to 0.79); the same was true for metastatic status (adjusted OR metastasis versus no metastasis 0.49, 95% CI = 0.35 to 0.70).

Conclusion

As COC is a core value for GPs and for most patients, special care should be taken to prevent a loss of COC around the time of a cancer diagnosis, and in the year after.
Unexpected loss of stereoselectivity in glycosylation reactions during the synthesis of chondroitin sulfate oligosaccharides
Authors: Mena-Barragán Teresa , de Paz José L , Nieto Pedro M
Published: January 2019

Here, we present an exploratory study on the fluorous-assisted synthesis of chondroitin sulfate (CS) oligosaccharides. Following this approach, a CS tetrasaccharide was prepared. However, in contrast to our previous results, a significant loss of β-selectivity was observed in [2 + 2] glycosylations involving N-trifluoroacetyl-protected D-galactosamine donors and D-glucuronic acid (GlcA) acceptors. These results, together with those obtained from experiments employing model monosaccharide building blocks, highlight the impact of the glycosyl acceptor structure on the stereoselectivity of glycosylation reactions. Our study provides useful data about the substitution pattern of GlcA units for the efficient synthesis of CS oligomers.
ANALYSIS OF THE FIRE‐PROTECTION IMPREGNATION INFLUENCE ON WOOD STRENGTH
Authors: Bednarek Zoja , Kaliszuk-Wietecka Agnieszka
Published: January 2019

The paper presents the description, results and result analysis for the effect of fire‐protection impregnation with a salt‐containing agent, made by a vacuum‐and‐pressure method, on wood strength. A significant effect of this impregnation type was proven for the strength types as follows: static bending, tension, lengthwise compression (ie along fibres), crosswise compression (ie across fibres), as well as for dynamic bending and impact strength in normal and elevated temperatures.
ANALYSIS OF THE EFFECTS OF MINERAL ADMIXTURES ON THE STRENGTH OF MORTARS: APPLICATION OF THE PREDICTIVE MODEL OF FERET
Authors: Boudchicha Abdelaziz , Zouaoui Mustapha Cheikh , Gallias Jean-Louis , Mezghiche Bouzidi
Published: January 2019

The introduction of fine and ultra‐fine mineral admixtures in cementing materials generates a granular effect, a physico‐chemical and micro‐structural effect and, possibly, chemical effect. To analyse the specific share of each effect, we propose to use a methodology based on a volume substitution of cement by admixtures in mixes whose absolute volume of the solid phases and workability are preserved constant and then only the effects of the particles of admixtures in the cementing phase are taken into account. We expressed the compressive strength of mortars with admixtures according to a factor of compactness by applying to the mortars the principles of the predictive model of Feret. This factor makes possible to distinguish the modifications generated by the granular effect of the admixtures on the compactness of the cementing matrix independently of the physico‐chemical and chemical effects. The specific chemical action of each admixture has been evaluated by analysing the variation of the coefficient of activity K according to the rate of the cement substitution, by applying to the studied mortars the concept of the equivalent binder and by deducing the coefficient of activity from the predictive model of Feret.
BEHAVIOUR OF HOLLOW CONCRETE‐FILLED STEEL TUBULAR COMPOSITE ELEMENTS
Authors: Kuranovas Artiomas , Kvedaras Audronis Kazimieras
Published: January 2019

Behaviour of composite steel‐concrete elements in various loading stages is quite well analysed by theoretical investigations and experiments. Concrete‐Filled Steel Tube (CFST) is one of many composite elements used at present in civil engineering. Different approaches and design philosophies were adopted in different design codes for it. But for hollow CFST elements, which are more effective than ordinary CFST, any code does not provide information about how to design these elements. Further investigations of hollow composite CFST elements are needed. In loading stage, when a particular level of stresses exists, an interaction between steel tube and concrete core appears and therefore a complex stress state of element takes place, which increases the load‐bearing capacity of the whole composite element. This interaction between components of CFST elements is reached because of different material properties, such as Poisson's ratio, elasticity modulus etc. In this article reasons of the above‐mentioned complex stress state appearance and behaviour of hollow CFST element components in different load stages of compressed stub structural member are analysed. The test results are presented in diagrams, tables. Previous researches of other investigators are summarised. Differences and similarities in behaviour of solid concrete and composite elements and hollow members with different number of concrete core layers are discussed.
THE ANALYSIS OF NON‐STRESS EFFECTS ON HISTORICAL STONE BRIDGE STRUCTURES (MONITORING, THEORETICAL ANALYSIS, MAINTENANCE)
Authors: Witzany Jiří , Zigler Radek
Published: January 2019

Due to non‐stress cyclic effects of temperature and moisture, stone bridge structures are subjected to deformations, a gradual growth of permanent deformations, crack development and subsequent disintegration of the stone masonry of bridge vaults. A theoretical analysis of the stress‐state and deformations of the stone bridge structure caused by non‐stress effects and the in‐situ monitoring of deformation changes of the breast walls and the bridge vaults of the historic structure of Charles Bridge (from the mid‐14th century) manifested a response and a growth in permanent deformations and disintegration of the stone bridge structure due to the effects of temperature and moisture. The behaviour of the bridge structure is significantly affected by the interaction of the vault bridge structure with the bridge body filler when exposed to the above‐mentioned non‐stress effects. Special attention must be paid to the spacing effect of filling layers on the stone bridge structure. When repairing historical stone bridge structures, the rehabilitation methods commonly used increase the total rigidity of the stone bridge structure and thus its sensitivity to non‐stress effects caused by changes in temperature.
STATIC BEHAVIOUR ANALYSIS OF MASTS WITH COMBINED GUYS
Authors: Jatulis Donatas , Kamaitis Zenonas , Juozapaitis Algirdas
Published: January 2019

The purpose of this study was to develop a new type of guyed mast that incorporates a complex guy cable system with a particular focus on the effect of static loading on the response mast behaviour. The intension of such solution is to increase a number of elastic supports for the mast shaft that will impact on its stability under loading. The static analysis of a one‐level guyed mast has been undertaken. The effects of geometrical and physical design parameters on the displacements of the mast were determined. The analysis is illustrated with two‐guyed masts: the bending moments and lateral displacements were determined for a typical guyed mast and guyed mast with combined guys.
TESTING ALKALI-REACTIVITY OF SELECTED CONCRETE AGGREGATES
Authors: Owsiak Zdzisława
Published: January 2019

In the present paper, results of alkali reactivity tests for selected silica aggregates, both rapid and slow alkali reactive, with the use of ASTM procedures, have been presented. The tests have covered the determination of the aggregate silica content dissolved in a solution of sodium hydroxide; scale of the expansion of mortar and concrete bars with the silica aggregate and high‐alkali cement; as well as scale of the expansion of the mortar bars stored in a sodium hydroxide solution at 80 °C. Exemplary photographs of the microstructure of alkali reaction products for the selected silica aggregates have also been presented. Summing up the results of standard methods of the aggregate testing, considering their alkali sensitivity, the method which tests the deformation of the concrete bars including the aggregate at issue and increased alkali content cement seems to be the most conclusive. However, the test duration up to 180 days is too short, particularly for defining the slow‐reactive aggregates reactivity, such as, for example, granites or quartzites. A major diagnostic symptom which confirms the occurrence of the alkali‐aggregate reaction is the presence of the reaction products (alkali silicate gel) in the concrete.
A CHECKLIST FOR ASSESSING SUSTAINABILITY PERFORMANCE OF CONSTRUCTION PROJECTS
Authors: Shen Li-Yin , Hao Jian Li , Tam Vivian Wing-Yan , Yao Hong
Published: January 2019

Construction sustainability performance is indispensable to the attainment of sustainable development. Various techniques and management skills have previously been developed to help improving sustainable performance from implementing construction projects. However, these techniques seem not being effectively implemented due to the fragmentation and poor coordination among various construction participants. There is a lack of consistency and holistic methods to help participants implementing sustainable construction practice at various stages of project realisation. This paper develops a framework of sustainability performance checklist to help understanding the major factors affecting a project sustainability performance across its life cycle. This framework enables all project parties to assess the project sustainability performance in a consistent and holistic way, thus improving the cooperation among all parties to attain satisfactory project sustainability performance.
INFLUENCE OF PARTIAL SAFETY FACTORS ON DESIGN RELIABILITY OF STEEL STRUCTURES ‐ PROBABILITY AND FUZZY PROBABILITY ASSESSMENTS
Authors: Kala Zdeněk
Published: January 2019

The paper is aimed at the analysis of the influence of partial safety factors on the reliability of designing steel members. The reliability assessment of a steel member is based on extensive experimental research on real material and geometric characteristics evaluated by samples obtained from frequently manufactured products. Material and geometric characteristics are random variables represented by histograms during the probabilistic assessment of reliability. The random variability of structural dimensions and of material characteristics does not present the only source of uncertainty present during design according to standards. The reliability of steel structures design is also dependent on the partial safety factor values, which are specified by the design standards. Partial safety factors are basic indicators, which determine structural dimensions in relation to loading. The probabilistic assessment of reliability is performed as a parametric study in the first part of the numerical analysis. The probability of failure is analysed in dependence on values of partial safety factors of material, permanent loading and long time variable loading. Partial safety factors are considered as fuzzy numbers with triangular membership functions in the second part of the numerical analysis. Membership functions of failure probability are evaluated using the general extension principle. The most important results are then summarised and additional applications of the verifications of limit states design criteria are described.
DNA barcoding data release for Coleoptera from the Gunung Halimun canopy fogging workpackage of the Indonesian Biodiversity Information System (IndoBioSys) project
Authors: Cancian de Araujo Bruno , Schmidt Stefan , Schmidt Olga , von Rintelen Thomas , von Rintelen Kristina , Floren Andreas , Ubaidillah Rosichon , Peggie Djunijanti , Balke Michael
Published: January 2019

We present the results of a DNA barcoding pipeline that was established as part of the German-Indonesian IndobioSys project - Indonesian Biodiversity Information System. Our data release provides the first large-scale diversity assessment of Indonesian coleoptera obtained by canopy fogging. The project combined extensive fieldwork with databasing, DNA barcode based species delineation and the release of results in collaboration with Indonesian counterparts, aimed at supporting further analyses of the data. Canopy fogging on 28 trees was undertaken at two different sites, Cikaniki and Gunung Botol, in the south-eastern area of the Gunung Halimun-Salak National Park in West Java, Indonesia. In total, 7,447 specimens of Coleoptera were processed, of which 3,836 specimens produced DNA barcode sequences that were longer than 300 bp. A total of 3,750 specimens were assigned a Barcode Index Number (BIN), including 2,013 specimens from Cikaniki and 1,737 specimens from Gunung Botol. The 747 BINs, that were obtained, represented 39 families of Coleoptera. The distribution of specimens with BINs per tree was quite heterogeneous in both sites even in terms of the abundance of specimens or diversity of BINs. The specimen distribution per taxon was heterogeneous as well. Some 416 specimens could not be identified to family level, corresponding to 72 BINs that lack a family level identification. The data have shown a large heterogeneity in terms of abundance and distribution of BINs between sites, trees and families of Coleoptera. From the total of 747 BINs that were recovered, 421 (56%) are exclusive from a single tree. Although the two study sites were in close proximity and separated by a distance of only about five kilometres, the number of shared BINs between sites is low, with 81 of the 747 BINs. With this data release, we expect to shed some light on the largely hidden diversity in the canopy of tropical forests in Indonesia and elsewhere.
A survey of parasitoids from Greece with new associations
Authors: Kavallieratos Nickolas G. , Stanković Saša S. , Schwarz Martin , Alissandrakis Eleftherios , Athanassiou Christos G. , Floros George D. , Žikić Vladimir
Published: January 2019

We report 22 parasitoid species from Greece that have emerged from their hosts belonging to Blattodea, Coleoptera, Hymenoptera and Lepidoptera, including 12 Braconidae, one Eulophidae, one Evaniidae, seven Ichneumonidae, and one Tachinidae. Nine parasitoids are reported for the first time in Greece, i.e., three Ichneumonidae:Campoplexdifformis(Gmelin, 1790),Gelisalbipalpus(Thomson, 1884), andLysibiatenaxTownes, 1983; five Braconidae:CharmoncruentatusHaliday, 1833,Dendrosoterprotuberans(Nees, 1834),Dolichogenidealongipalpis(Reinhard, 1880),Ecphylussilesiacus(Ratzeburg, 1848), andSpathiuscurvicaudisRatzeburg, 1844; and one Eulophidae:Melittobiaacasta(Walker, 1839). Nine of the 23 recorded parasitoid-host associations are new. These findings are discussed in relation to the overall related parasitoid-host associations in the target area, as well as the potential of parasitoid use in the biological control of pests.
Taxonomic review of the Asian Trogloneta species (Araneae, Mysmenidae)
Authors: Li Ya , Lin Yucheng
Published: January 2019

FiveTroglonetaspecies from Southwest China and Japan are reviewed that two new combinations and a new synonymy are proposed in the current paper:T.nojimai(Ono, 2010),comb. n.is transferred fromMysmena,T.yunnanense(Song & Zhu, 1994),comb. n.(=T.denticocleariLin & Li, 2008,syn. n.) is transferred fromPholcommaof the Theridiidae,T.speciosumLin & Li, 2008,T.uncataLin & Li, 2013, andT.yuensisLin & Li, 2013. The female ofT.yuensisis described for the first time. An identification key and diagnoses are provided for these species, as well as new photographs or illustrations of the genital organs and habitus ofT.yuensisandT.yunnanense.
A new species of Erythrolamprus from the oceanic island of Tobago (Squamata, Dipsadidae)
Authors: Murphy John C. , Braswell Alvin L. , Charles Stevland P. , Auguste Renoir J. , Rivas Gilson A. , Borzée Amaël , Lehtinen Richard M. , Jowers Michael J.
Published: January 2019

Tobago is a small island on the southeast edge of the Caribbean Plate with a continental flora and fauna. Using DNA sequences from Genbank, new sequences, and morphological data from the snakesErythrolamprusepinephalus,E.melanotus,E.reginae, andE.zweifeli, the species status of specimens of a Tobago snake previously considered to beErythrolamprusreginaewas assessed.Erythrolampruszweifeli, long considered a subspecies ofE.reginae, was found to be a northern Venezuela-Trinidad endemic and the sister toE.reginae. The trans-Andean speciesE.epinephalusis shown to be non-monophyletic while the Costa Rican lineage ofE.epinephalusis weakly supported as the sister to the Tobago population. The TobagoErythrolamprusis described as a distinct taxon based upon five specimens from four localities in lower montane rainforest. Much of the new species range includes the Main Ridge Forest Reserve of Tobago, the oldest protected forest in the Western Hemisphere. All known locations fall within a 400-ha area, and its total geographic distribution is likely to be less than 4,566 ha. The restricted distribution of this new snake makes it a likely candidate for threatened status. The new species also becomes another biogeographic link between northern Venezuela and Tobago.
Revision of the genus Cephalobyrrhus of Japan and Taiwan (Coleoptera, Limnichidae)
Authors: Yoshitomi Hiroyuki
Published: January 2019

Japanese and Taiwanese species of the genus Cephalobyrrhus are revised. A new species, C.amamisp. n., is described from Amami-Ôshima, the Ryukyus, Japan. This species is clearly distinguished from the other known species by the short and pointed median lobe and long phallobase. Two previously known species from Japan and Taiwan, C.latus and C.japonicus, are redescribed.
Efficacy of Methotrexate in Real-world Management of Giant Cell Arteritis: A Case-control Study
Authors: Koster Matthew J. , Yeruva Karthik , Crowson Cynthia S. , Muratore Francesco , Labarca Cristian , Warrington Kenneth J.
Published: January 2019

Objective.

To determine the effect of methotrexate (MTX) on relapse risk and glucocorticoid (GC) use in a large single-institution cohort of patients with giant cell arteritis (GCA).

Methods.

Patients diagnosed with GCA from 1998 to 2013 with confirmed evidence of temporal artery biopsy and/or radiographic evidence of large vessel vasculitis were identified. Each patient with GCA treated with adjunct MTX (case) was matched to a similar patient with GCA treated only with GC (control). GC requirements and relapse events before and after MTX initiation (or corresponding index date) were compared using rate ratios (RR).

Results.

Eighty-three cases and 83 controls were identified and compared. No significant differences in age, demographics, laboratory variables, baseline disease characteristics, or mean initial prednisone doses were observed. Median [interquartile range (IQR)] time from GCA diagnosis to MTX initiation in cases was 39 (13–80) weeks and the median (IQR) starting dose was 13.5 (10–15) mg/week. RR comparing relapse rates before and after MTX initiation/index date were significantly reduced in both cases (RR 0.32, 95% CI 0.24–0.41) and controls (RR 0.60, 95% CI 0.43–0.86). The decrease in relapse rate was significantly greater in patients taking MTX than in those taking GC alone (p = 0.004). Rates of GC discontinuation did not differ between groups.

Conclusion.

In this large single-institution cohort, the addition of MTX to GC decreased the rate of subsequent relapse by nearly 2-fold compared to patients taking GC alone. MTX may be considered as adjunct therapy in patients with GCA to decrease the risk of further relapse events.
Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort
Authors: Guzman Jaime , Henrey Andrew , Loughin Thomas , Berard Roberta A. , Shiff Natalie J. , Jurencak Roman , Huber Adam M. , Oen Kiem , Gerhold Kerstin , Feldman Brian M. , Scuccimarri Rosie , Houghton Kristin , Chédeville Gaëlle , Morishita Kimberly , Lang Bianca , Dancey Paul , Rosenberg Alan M. , Barsalou Julie , Bruns Alessandra , Watanabe Duffy Karen , Benseler Susanne , Duffy Ciaran M. , Tucker Lori B.
Published: January 2019

Objective.

To estimate the probability of early remission with conventional treatment for each child with juvenile idiopathic arthritis (JIA). Children with a low chance of remission may be candidates for initial treatment with biologics or triple disease-modifying antirheumatic drugs (DMARD).

Methods.

We used data from 1074 subjects in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcome was clinically inactive disease for ≥ 6 months starting within 1 year of JIA diagnosis in patients who did not receive early biologic agents or triple DMARD. Models were developed in 200 random splits of 75% of the cohort and tested on the remaining 25% of subjects, calculating expected and observed frequencies of remission and c-index values.

Results.

Our best Cox logistic model combining 18 clinical variables a median of 2 days after diagnosis had a c-index of 0.69 (95% CI 0.67–0.71), better than using JIA category alone (0.59, 95% CI 0.56–0.63). Children in the lowest probability decile had a 20% chance of remission and 21% attained remission; children in the highest decile had a 69% chance of remission and 73% attained remission. Compared to 5% of subjects identified by JIA category alone, the model identified 14% of subjects as low chance of remission (probability < 0.25), of whom 77% failed to attain remission.

Conclusion.

Although the model did not meet our a priori performance threshold (c-index > 0.70), it identified 3 times more subjects with low chance of remission than did JIA category alone, and it may serve as a benchmark for assessing value added by future laboratory/imaging biomarkers.
Use of Anakinra in Hospitalized Patients with Crystal-associated Arthritis
Authors: Liew Jean W. , Gardner Gregory C.
Published: January 2019

Objective.

In this retrospective observational study, we assess the efficacy and safety of the interleukin 1 receptor antagonist anakinra in medically complex, hospitalized patients with acute gout and calcium pyrophosphate crystal arthritis.

Methods.

Adult inpatients treated with anakinra from 2014 to 2017 were identified for inclusion. Charts were reviewed for demographics, comorbidities, laboratory data, pain scores, joint involvement, prior treatment, dosing and response to anakinra, concurrent infections, and surgical interventions. Response to anakinra treatment was determined from review of provider documentation, as well as recorded pain scores on a numeric scale.

Results.

We identified 100 individuals accounting for 115 episodes of arthritis. This population was 82% male, with an average age of 60 years. Comorbidities included renal disease (45%) and history of organ transplantation (14%). Twenty-nine episodes of arthritis occurred in the perioperative setting. Concurrent infection was present in 34 episodes. Eighty-six episodes of arthritis had partial or complete response to anakinra within 4 days of treatment initiation; 66 episodes had partial or complete response within 1 day of anakinra administration. Anakinra was well tolerated.

Conclusion.

To our knowledge, this is the largest observational study of anakinra use in the inpatient setting for the acute treatment of crystal-associated arthritis. We observed a rapid response to anakinra, with 75% of episodes significantly improving or completely resolving within 4 days of the first dose. Our data also support the use of this biologic agent in individuals with infections, as well as perioperative individuals and immunosuppressed transplant recipients.
Improving Benefit-harm Assessment of Therapies from the Patient Perspective: OMERACT Premeeting Toward Consensus on Core Sets for Randomized Controlled Trials
Authors: Andersen Kathleen M. , Cheah Jonathan T.L. , March Lyn , Bartlett Susan J. , Beaton Dorcas , Bingham Clifton O. , Brooks Peter M. , Christensen Robin , Conaghan Philip G. , D’Agostino Maria-Antonietta , de Wit Maarten , Dueck Amylou C. , Goodman Susan M. , Grosskleg Shawna , Hill Catherine L. , Howell Martin , Mackie Sarah L. , Richards Bethan , Shea Beverly , Singh Jasvinder A. , Strand Vibeke , Tugwell Peter , Wells George A. , Simon Lee S.
Published: January 2019

Objective.

Outcome Measures in Rheumatology (OMERACT) convened a premeeting in 2018 to bring together patients, regulators, researchers, clinicians, and consumers to build upon previous OMERACT drug safety work, with patients fully engaged throughout all phases.

Methods.

Day 1 included a brief introduction to the history of OMERACT and methodology, and an overview of current efforts within and outside OMERACT to identify patient-reported medication safety concerns. On Day 2, two working groups presented results; after each, breakout groups were assembled to discuss findings.

Results.

Five themes pertaining to drug safety measurement emerged.

Conclusion.

Current approaches have failed to include data from the patient’s perspective. A better understanding of how individuals with rheumatic diseases view potential benefits and harms of therapies is essential.
The Third Biennial 2018 OMERACT First-time Participant Program: A Qualitative and Quantitative Study
Authors: Sloan Victor S. , Grosskleg Shawna , Wells George , Singh Jasvinder A.
Published: January 2019

Objective.

To assess the expanded/refined first-time participant training program.

Methods.

We conducted a refined new participant program at OMERACT 2018 on days 1–4, in which first-time participants provided feedback with online surveys and a nominal group on Day 4.

Results.

Twenty first-time participants attended the introductory session and 8–12 attended followup sessions. A high proportion valued the newbie session (100%), rating it overall (91%), content-wise (62%), for presentation quality (82%), and value for the money (82%) as outstanding or good. The nominal group technique identified opportunities for further improvement of breakouts/voting.

Conclusion.

The expanded new participant training program is valued by attendees.
Une théorie économique de l’exploitation salariale
Authors: Cartelier Jean
Published: January 2019

La thèse défendue dans ce qui suit est que le salaire n’est pas le prix d’une marchandise (bien ou service) s’établissant sur un marché ; il est le paiement par lequel des individus, ne pouvant être producteurs de marchandises, acceptent de travailler au sein d’une entreprise sous le contrôle et pour le compte d’un entrepreneur. La différence entre le statut de salarié et celui de l’individu marchand est à la source d’une exploitation inhérente à la relation salariale (exploitation identifiée par Marc Fleurbaey comme étant la M-exploitation ). JEL :  A 10, B 20, J 30
Paiements, esclavage et exploitation : éléments d’un triptyque
Authors: Darmangeat Christophe
Published: January 2019

On construit une base de données portant sur 240 sociétés afin de tester les relations entre stockage, esclavage et paiements. Les résultats confirment globalement les propositions d’Alain Testart. Les paiements constituent un indice globalement sûr de la présence de la richesse et de l’exploitation et, à de très rares exceptions près, c’est au sein de cet ensemble social que se rencontre l’esclavage. Dans une perspective matérialiste, l’origine techno-économique des paiements doit toutefois être située, au-delà du seul stockage alimentaire, plus largement dans la production de biens meubles, durables et nécessitant une importante quantité de travail. JEL Codes : Z13, B14
Le corps dans la culture hypermoderne. Représentations et valeurs
Authors: Tapia Claude
Published: January 2019

Cet article traite de la problématique des rapports entre les représentations sociales concernant le corps et des évolutions culturelles et sociales plus globales. Il apparaît dans notre analyse que le corps, au cours de diverses étapes, depuis le début du xx e  siècle, peut être appréhendé comme le siège de nombreuses transformations, et aussi comme le lieu d’inscription des signes de la libération morale et sexuelle, bref comme l’écran sur lequel se projette la lutte incessante du conservatisme et de la modernité. L’évolution des représentations sociales révélée par les productions littéraires, le cinéma, le théâtre ou la danse… renseigne sur le statut ambigu du corps dans l’imaginaire social et sur les tendances contradictoires qui s’esquissent à notre époque.
Les nouveaux corps du capitalisme
Authors: Linhart Danièle
Published: January 2019

Cet article vise à identifier la nature du management des corps des salariés dans le cadre du travail « post taylorien ». Malgré un travail qui devient de plus en plus abstrait, l’organisation spatiale des corps comme la focalisation sur le bien-être corporel occupent, dans le management moderne, une place importante, qui peut paraître intrigante. On fait ici l’hypothèse qu’il s’agit de modeler l’identité et les représentations des cadres, ingénieurs, experts, en leur faisant prendre conscience qu’ils sont des salariés subordonnés comme les autres, par une gestion de leur inscription spatiale qui les renvoie à l’image de forces de travail contrôlées. Si le taylorisme visait à rapprocher l’homme de l’état de machine, le management moderne utilise les corps comme vecteurs de disciplinarisation, pour y incorporer en même temps qu’une identité de subordonné, un vécu individuel composé d’aspirations narcissique et de satisfactions liées non pas tant au respect de la professionnalité mais qu’à une bienveillante prise en charge du bien-être.
La psyché du corps connecté et transformé, entre contenance et augmentation
Authors: Tordo Frédéric
Published: January 2019

Avec Freud, puis Anzieu, nous avons appris qu’une fonction psychique se développe par étayage sur une fonction corporelle dont elle transpose le fonctionnement sur le plan psychique. Ce texte parcourt une hypothèse complémentaire à l’ère du corps hypermoderne : les fonctions psychiques trouvent un appui sur la technologie, et ses fonctions, qu’elles transcrivent dans la psyché. La fonction de contenance/augmentation est présentée : à la technologie qui épouse la surface du corps, ou simplement à laquelle le sujet est « connecté », répond la fonction contenante d’une partie du Moi – que nous nommons Moi-cyborg . Ce qui implique une extension des limites du Moi, donc de la surface psychique. Une vignette clinique illustrera cette fonction, et la manière dont elle colmate, artificiellement, une psychopathologie de la contenance.
Le transhumanisme : incarnation de l’hypermodernisme… ou fuite en avant fantasmatique ?
Authors: Derian Maxime
Published: January 2019

Le transhumanisme apparu dans la seconde moitié du xx e siècle est un catalyseur idéologique d’une concentration monopolistique en cours dans le cadre de l’avènement, à l’échelle planétaire, de l’hypermodernité. Il réactualise le vieux fantasme de la jeunesse infinie et la croyance en l’immortalité de l’âme en utilisant la technoscience pour argumenter en faveur de sa faisabilité. Ce qui joue en faveur du transhumanisme, c’est que nous avons tous envie d’y croire car cela flatte un désir latent de s’affranchir de nos limites. Pourtant, ce sont précisément nos limites qui structurent la forme et l’harmonie de notre corps et de notre psyché et donnent un sens à nos existences.
Des corps hypermodernes
Authors: Le Breton David
Published: January 2019

Dans nos sociétés contemporaines, le corps est devenu une sorte de terminal pour l’individu, un objet fluide, transformable, un work in process . Pour les uns, il s’agit de le transformer, de s’en jouer, d’autres veulent s’en débarrasser, la plupart, sans doute, ne s’en soucient guère, ils le considèrent comme l’incarnation de leur expérience du monde et ne songent nullement à le congédier ou à l’« améliorer ». Ainsi des centaines de millions de marcheurs à travers le monde disent leur bonheur de vivre l’incarnation sensible de leur rapport au monde, sans souci de performance ou d’efficacité. Pour le transhumanisme, il est surnuméraire, lieu de la fragilité de la condition humaine il convient de s’en débarrasser. Les limites du corps interrogent les limites du lien social et les limites de soi.
Psychanalyse et médecine, ou la « méthode Balint »
Authors: Meslem Mustapha
Published: January 2019

Résumé Michael Balint a perpétué l’école de Budapest en Angleterre, avec la création des « Groupes de recherche formation » qui deviendront les « groupes Balint ». Il est l’un des instigateurs du Middle Group, dont le principal porte-parole sera Donald W. Winnicott. Il inventera et développera les notions d’investissement mutuel, de fonction apostolique, de défaut fondamental, de régression et de confusion des langues.
Les Unités Hospitalières Spécialement Aménagées : des structures de soins
Authors: Touitou David
Published: January 2019

Les Unités Hospitalières Spécialement Aménagées (UHSA) sont des structures d’hospitalisation à temps complet de création récente. Elles viennent renforcer l’offre de soins disponible pour la population pénale. Bien trop facilement attaquées à leur création, y compris par des professionnels du milieu carcéral, elles ont su prendre leur place au sein du dispositif de soins psychiatriques et répondre au moins à une partie non négligeable des besoins des personnes détenues.
Approche systémique et défense des droits de l’Homme
Authors: Pregno Gilbert
Published: January 2019

L’approche systémique nous introduit à la pensée complexe, à la prise en compte de la globalité, elle nous invite avec la deuxième cybernétique à définir notre responsabilité et notre engagement non pas seulement dans la solution des difficultés, mais aussi dans son maintien. Après plus d’un demi-siècle, l’approche systémique revêt encore son caractère innovateur, ce dont témoigne l’abondance de pratiques et d’outils. Quelle attitude prendre par rapport à la question des droits de l’homme dont le non-respect peut envahir la vie des personnes que nous prenons en charge et impacte les institutions dont nous faisons partie ? Il s’avère qu’un engagement pour les droits humains, leur défense, se marie fort bien avec la démarche du systémicien. Si le systémicien interpelle la place du symptôme, le défenseur des droits humains prolonge la pensée et l’intervention du premier pour positionner nos institutions et notre société face aux injustices qu’elles produisent et qui ne trouvent pas leur origine dans le système familial. Cette interface est riche et remet l’intervenant face à ses responsabilités qui l’obligent à se questionner sur sa place à lui dans le contexte plus large qui est celui de sa pratique et de la place qu’il occupe dans les institutions, de la société dans laquelle il vit et de la planète qu’il habite.
Intellectual Disabilities and Health Care Communication: A Continuing Education Program for Providers
Authors: Primeau Marlena Seibert , Talley Brenda
Published: January 2019

Communication with others is a core human imperative; this is especially true in health care. Individuals with intellectual disabilities often face daunting challenges in both health literacy and communicating their health needs and questions. Education for professionals in specialized communication is critical in improving care for their clients with intellectual disabilities. To address this issue, an educational framework, ID-COMMUNICATE, was created to guide improved interactions between health care providers and clients with intellectual disabilities and was further developed into a continuing education program. The modules of the ID-COMMUNICATE program focus on specialized communication techniques and strategies and related professional practice issues. This program can be disseminated in a variety of ways and is easily adapted for professionals in many disciplines. [
J Contin Educ Nurs.
2019;50(1):20–25.]
Adjunctive Nutrition Therapy for Depression
Authors: Yeum Tae-Sung , Maggiolo Nicolette Star , Gupta Carina Taylor , Davis Brett J. , Nierenberg Andrew A. , Sylvia Louisa G.
Published: January 2019

Depression is the leading cause of global disability, and many patients fail to respond to standard treatments. Preliminary evidence suggests that adjunctive nutrition therapy may improve treatment outcomes in depression. We review the evidence for the efficacy and/or mechanisms of the following nutrients: vitamin D, vitamins B12 and B9, vitamin C, zinc, selenium, omega-3 fatty acid, N-acetylcysteine, and nicotinamide riboside. Preliminary evidence suggests that these nutrients may facilitate mood regulation by regulating neurotransmitters, engaging in reduction-oxidation, or by modulating neuronal structure. Although initial evidence is promising, large, placebo-controlled studies are needed to validate their efficacy.

[
Psychiatr Ann.
2019;49(1):21–25.]
Evolution of a Retinoma Case in 21 Years
Authors: Theodossiadis Panagiotis , Emfietzoglou Ioannis , Grigoropoulos Vlassis , Moschos Michael , Theodossiadis George P
Published: January 2019

Abstract. A 35-year-old man was observed during a 21 -year period with fundus color photography, fluorescein angiography, and B-scan ultrasonography for a presumed retinoma detected in his left eye during routine ophthalmoscopy in 1982. The patient was a carrier of the 13ql4 retinoblastoma gene. His retinal lesion remained stable during the follow-up period without signs of malignant transformation. Retinomas are most commonly observed in patients with retinoblastoma and their relatives. In this case, none of the patient's parents, siblings, or children had evidence of a retinal tumor. Photographic documentation of the nonprogressive nature of this presumed retinoma is provided and demonstrates the absence of growth. [Ophthalmic Surg Lasers Imaging 2005;36:155-157.]
Conjunctival Squamous Cell Carcinoma With Perineural Invasion Resulting in Death
Authors: Kaines Andrew , Davis Garry , Selva Dinesh , Leibovitch Igal , Dodd Thomas , Malhotra Raman
Published: January 2019

Abstract. Conjunctival squamous cell carcinoma is generally a low-grade malignancy. A 42-year-old man presented with histologic evidence of extra-tumoral perineural invasion associated with an incompletely excised limbal conjunctival squamous cell carcinoma. Despite further surgery, close observation, plaque radiotherapy, and eyelid-sparing orbital exenteration followed by external beam radiotherapy, the patient developed intracranial perineural invasion with involvement of the trigeminal and facial nerves, ultimately resulting in death. Repeated magnetic resonance imaging with contrast failed to detect perineural invasion until late in the course of disease. Awareness of the possibility of perineural invasion in patients with conjunctival squamous cell carcinoma and of its aggressive nature may be life-saving. Nevertheless, even with initial aggressive tumor control, some patients will show an aggressive tumor growth with recurrences. [Ophthalmic Surg Lasers Imaging 2005;36:249-251.]