bluuebunny/crossref_metadata_2025 huggingface dataset:
Ancylostomiasis case in a physician-dermatologist practice
Authors: Efanova E. N. , Savenko E. L. , Rusak J. E. , Fediv L. L.
Published: February 2022

Hookworm disease (larva migrans) observation of a nematosis worms group is presented. Diagnosis and the treatment of a 28-year-old patient from an endemic area, who has hookworm disease, are described.
PH OF THE TOPICAL DRUG VEHICLE: SELECTING AN OPTIMUM VALUE AND ROLE OF THE BUFFER SYSTEM
Authors: Dukhanin A. S.
Published: February 2022

The following three groups of factors must be taken into consideration for selecting an optimum pH value of a topical drug: pharmaceutical, pharmacological and compatibility factors. To ensure a stable pH value, the drug vehicle comprises different buffer systems: single component and two-component ones. The optimum conditions for selecting and maintaining the vehicle pH were examined by the example of glucocorticosteroid-based topical drugs.
Ultratone therapy for the complex treatment of localized scleroderma
Authors: Sorokina N. V. , Tlish M. M.
Published: February 2022

The examination and treatment of 48 patients with circumscribed scleroderma were conducted. Two groups of these patients were formed with method of adaptive randomization. In the control group complex treatment underwent according to the standards in this nosology. In the study one, we conducted ultratonotherapy. The course of treatment was 21 days in both groups. Treatment results were evaluated in accordance with the dynamics of cutaneous pathological process and microcirculation in the area of lesions. In the process of treatment positive clinical dynamics appeared in the study group earlier and were accompanied by increased blood flow. The results indicate that ultrasonotherapy increases the efficiency and reduces the treatment time of patients with circuscrimbed scleroderma.
Microbiome: a new era in normal and pathological changes skin studies
Authors: Araviiskaia E. R. , Sokolovskiy E. V.
Published: February 2022

The paper contains review of studies on microbiota and cutaneous microbiome using modern techniques of methagenomic analysis. The existing data on microflora of normal skin and among the patients with acne, seborrhoeic dermatitis, rosacea atopic dermatitis are consequently analyzed. The interaction between microbiome and innate/adaptive immunity is presented The perspectives of knowledge on microbiome both in dermatology and cosmetology are pointed out.
Using clobetasol propionate in the form of a shampoo for the treatment of patients suffering from psoriasis localized in the scalp area
Authors: Bakulev A. L. , Kravchenya S. S. , Igonina I. A. , Utz S. R.
Published: February 2022

The study involved 80 adult psoriatic patients with scalp affections at the dermatosis progressing stage. The authors compared scalp psoriasis topical treatment options such as using 0.05% clobetasol propionate in the form of a shampoo, and successive administration of the 2% salicylic acid ointment and aforesaid short-term topical product in patients with vulgar or exudative dermatoses using dynamic scores such as mPASI, DLQI and itching intensity degree. It was demonstrated that 0.05% clobetasol propionate used in the form of a shampoo is characterized by a high efficacy and safety profile for patients with vulgar or exudative psoriasis of the scalp. At the same time, in case of exudative dermatosis successive topical treatment with the use of the 2% salicylic acid ointment and 0.05% clobetasol propionate in the form of a shampoo contributes to the clearance of psoriatic foci from accumulated scales and enables a potent topical corticosteroid such as clobetasol to efficiently reduce principal clinical symptoms of scalp psoriasis such as erythema, infiltration, exfoliation and itching. Using the clobetasol shampoo reduces the scalp itching intensity as the key psoriatic symptom preventing an isomorphic reaction as a result of foci traumatization related to scratching.
The experiment of using loratadinum in pregnant women with pruritic dermatoses
Authors: Monakhov K. N. , Kholodilova N. A.
Published: February 2022

Results of examination of 64 pregnant women with allergic dermatosis. Provides results of the efficacy, tolerance and safety study of the loratadinum drug in pregnant women with allergic dermatosis.
Osteoporosis as a result of the long-term administration of glucocorticoids in patients suffering from acantholytic pemphigus
Authors: Ufimtseva M. A. , Bochkarev YU. M. , Gurkovskaya E. P. , Puhtinskaya P. S. , Nikolaeva K. I. , Lesnaya O. D.
Published: February 2022

Goal. To study the prevalence of glucocorticoid-induced osteoporosis in patients suffering from acantholytic pemphigus and risk of osteoporosis-related fractures. Materials and methods. The study involved 26 patients including 12 patients suffering from acantholytic pemphigus. The patients underwent dual-energy X-ray absorptiometry (DXA) for calculating bone mineral density (BMD) as well as T and Z scores. To assess the ten-year probability (absolute risk) of fractures, the FRAX model was applied. Major results. Glucocorticoid-induced osteoporosis was diagnosed in 33.3% of the AP patients receiving a glucocorticoid therapy, and osteopenia was also diagnosed in 33.3% of them; an increased risk of osteoporosis-related fractures was observed in all of the patients over 40, which entails the need in early diagnostics of pathologic bone changes and prevention of complications such as osteoporosis-related fractures. Conclusion. A high share of complications (83.3%) related to systemic GCS stipulates the need in increased cooperation between dermatologists and allied specialists.
Onychomycosis: features external therapy
Authors: Zaslavsky D. V. , Chuprov I. N. , Sidikov A. A. , Khvedelidze M. G. , Tatarskaya O. B.
Published: February 2022

Onychomycosis - one of the most frequent diseases with defeat of a nail bed, matrics and nail plate of a fungal origin. Frequency of an onychomycosis in Russia reaches 5% (to 15 million people), and practically every tenth visit of the dermatologist is connected with this pathology. Treatment of an onychomycosis still remains very difficult task. Application of varnishes, ointments with antimycotics and local agents on an oil basis has an essential shortcoming - insufficient receipt of a preparation to the center of pathological changes. It is supposed that for optimum therapy it is necessary to influence: first, from frontal and distal part of a nail, secondly, to apply aqueous-alcoholic solutions of a preparation which can freely get into subnail spaces with the phenomena of an onycholysis. For example, it has been shown highly efficient application of naftifina a hydrochloride under control of solution of the diamond green, showing diffusion distribution active ingredient to subnail space and on channels.
Analysis of methods common topical treatment of the generalized dermatoses in the delivery of the specialized health care in the profile "Dermatology"
Authors: Kokhan M. M. , Samtsov A. V. , Perlamutrov YU. N. , Sokolovskiy E. V.
Published: February 2022

Results of sampling epidemiological investigation of patients with dermatologic diseases, which sought treatment in the specialized Russian outpatient facilities over two-month period, and assessments of approaches to treatment of patients with atopic dermatitis, psoriasis and eczema are presented. Data of 2991 individual registration cards, which were filled out by the dermatovenerologists providing primary specialized care to patients in outpatient facilities of Perm, Samara and St. Petersburg, was analyzed. It was observed that women were prevalent among patients with dermatoses, and most of women and men were of working age (82.2 and 89.2% corresponding). The nosological structure of appealability consists of 25.6% patients with dermatose, psoriasis (14.5%), eczema (13.4%), seborrhea and acne (8.6%), atopic dermatitis (5.8%), and pyodermatitis (3.2%). Using standardized indexes for assessment it was discovered that among applied outpatients 80% persons, presented with atopic dermatitis, and 50% persons, presented with psoriasis, had moderate and severe appearances of dermatoses. In therapy of patients with atopic dermatitis, psoriasis and eczema, specialists used widely standard system treatment - topic glucocorticosteroid agents for external care.
Methotrexate: Revisited efficiency and safety of drug administration in psoriasis patients
Authors: Bakulev A. L.
Published: February 2022

The article presents the current data of the literature on methotrexate, which is now one of the most commonly used preparation for the systemic treatment of patients with moderate to severe psoriasis. The following problems are under consideration: estimation by specialists of response to systemic psoriasis therapy and possible therapeutic strategies; selecting initial doses of methotrexate for the treatment of patients with psoriasis; the possibilities of combined use with genetically engineered biological agents and monitoring of therapy. The data from randomized clinical trials on the long-term continuous treatment with methotrexate (efficacy, safety); methods of its administration to patients and time and criteria for long-term effecasy are reported. There are presented the data on the mechanisms of methotrexate action and the new data about the impact on the adenosine metabolism and the ability of the preparation to modulate the inflammatory response in the skin of patients by inhibiting the cellular components of the inflammatory infiltrate in the skin (dendritic antigen-producing cells and T-lymphocytes), as well as the suppression of expression of some proinflammatory cytokines (IFN-y and IL17A).
Skin lesion at acute monoblastic leukemia (clinical observation)
Authors: Chernova N. G. , Sinicyna M. N. , Dvirnyk V. N. , Kovrigina A. M. , Zvonkov E. E. , Parovichnikova E. N.
Published: February 2022

At present diagnosis of acute leukemia does not represent any difficulties and is based on morphological and immunophenotypical bone marrow studies. The paper presents a non-standard verification algorithm of acute monoblastic leukemia in elderly female patient, with leukemic skin lesion. Morphologic and immunohistochemical studies of biopsy materials of skin, lymph node and bone marrow allow establishing a linear membership of tumor cells and promptly verifying the diagnosis of leukemia. Lack of the overall clinical examination in such cases leads to diagnostic errors and to late verification of the true diagnosis and significantly worsens the prognosis.
Reasonable antimicrobial therapy in patients with pyodermatosis
Authors: Miheev G. N. , Sokolovskij E. V. , Savicheva A. M.
Published: February 2022

The data are given about the history of the invention and development of antimicrobial therapy in the XX-th and the beginning of the XXI-th centuries. There are presented data on the pharmacological effects of antibacterial agents from different groups that are used for the treatment of patients with pyodermatosis, dose schedules, pharmacokinetics, adverse effects, contraindications, and medicine interactions. The main causes leading to the formation of resistant microorganism strains are pointed. Advances of broad-spectrum antibacterial antibiotics for treatment the pyodermic patients are demonstrated on the example of amoxicillin+clavulinic acid, josamycin and doxycycline monohydrate. The arguments justifying the need to refuse empiric administration of antibacterial therapy are presented. To select a rational causal initial therapy of patients with pyoderma it is necessary to use the results of microbiological study of etiology and pathogenic microflora sensitivity to antimicrobial preparations.
Programs of the preventive interventions against sexually transmitted infections in the high-risk subpopulations
Authors: Krasnoselskikh T. V. , Sokolovskiy E. V.
Published: February 2022

A review article highlights the practical issues of design, implementation and effectiveness estimation of STI prevention programs aimed to correct the behavior leading to infection. the importance of epidemiological modeling method for the organization of preventive interventions is discussed. the prospects of the multidisciplinary behavioral approach to STI prevention are demonstrated.
Assessment of prognostic predictive value at the mycosis fungoides
Authors: Zhukov A. S. , Telichko I. N. , Belousova I. E. , Samcov A. V.
Published: February 2022

Micosis fungoides is a primary skin lymphoma characterized with indolent disease course and favorable prognosis. Опіу at some patients one can observe aggressive development of the disease to malignant stage with the exracutaneous outspread. the modern data about the prognostic factors are presented in the review. Disclosure of these factors allows to forecast the course of disease. there is given attention to integral estimation of survival rates on the ground of tNMB-staging sand estimation of the CUP-index. Definition of combination of different prognostic factors would allow to create prognostic models enabling to diagnose on the early stages of disease the patients with high risk of progression of mycosis fungoides.
Aggressive systemic mastocytosis with skin involvement, the type of generaled urticaria pigmentosa (clinical case)
Authors: Sokolovskiy E. V. , Iastrebov V. V. , Shcherbatykh A. V. , Machulaitene E. R.
Published: February 2022

The authors describe the clinical observation of a case of the aggressive systemic mastocytosis with skin involvement, the type of generalized urticaria pigmentosa. They also present literature data concerning the etiology, pathogenesis, diagnosis and treatment of dermatosis.
NEW OPPORTUNITIES IN DRUG TREATMENT OF ATOPIC DERMATITIS
Authors: Perlamutrov YU. N. , Ol'hovskaya K. B. , Lyapon A. O.  , Ajvazova T. V.
Published: February 2022

Actuality. High incidence of atopic dermatitis and its association with systemic pathology determine the need of broad treatment options on the base of the modern data on pathophysiology of the disease. Aim of the study. Analysis of the clinical efficacy of the complex therapy with application drug Kestine® and probiotic FlorOK. Materials and Methods of the study. 55 patients with atopic dermatitis with mild and medium severity stages were examined and treated. The SCORAD Index and the Prurindex were used for assessment of AD severity; H2- test was used for evaluation of the digestive system function. Study results. It was stated high clinical efficacy of the complex therapy with application drug Kestine® and probiotic FlorOK accompanied by fast arrest of the itch.
ISOTRETHINOINE IN ACNE THERAPY
Authors: Tlish M. M. , SHavilova M. E.
Published: February 2022

Systemic retinoids are known to be the most effective means of treating severe forms of acne. However, in spite of longstanding and intensive practice of their application in dermatology, some specialists still avoid prescribing this group of drugs. As a rule, this is due to lack of awareness of health professionals about therapy techniques and means of correcting possible adverse events. We discuss the clinical aspects of administration of isotretinoin in treatment of moderate and severe forms of acne. Practical recommendations are given on how to prevent various myths, misconceptions and prejudices in health professionals and patients. We present our own experience of using isotretinoin with increased bioavailability (Acnecutan®*).
Prevalence of atopic dermatitis among children and teenagers in ural, siberian and far eastern federalregions
Authors: Keniksfest Yu V , Keniksfest Yu V
Published: February 2022

The author presents an analysis of prevalence of atopic dermatitis among children at the age of 0-14 and teenagers at
the age of 15-17 on the basis of data from official public statistical reports for the Russian Federation and for territories
of Ural, Siberia and Far East for the period of 2005-2009.
Experience of treating acne patients with acnecutan
Authors: Tlish M M , Tlish M M
Published: February 2022

The author describes her own positive experience of using a new innovation form of isotretinoin, the Acnecutan drug, for
the treatment of acne patients. The author provides the drug efficacy and tolerability assessment, describes the frequency
and intensity of adverse effects and discloses the methods for their prevention and elimination
Fractional CO2 laser: a new therapeutic system forphotobiomodulation of skin remodeling and cytokineproduction in the course of tissue reparation
Authors: Prignano F , Campolmi P , Bonnan P , Ricceri F , Cannarozzo G , Troiano M , Lotti T , Prignano F , Campolmi P , Bonnan P , Ricceri F , Cannarozzo G , Troiano M , Lotti T
Published: February 2022

Eighteen female patients with the signs of photoageing underwent skin rejuvenation using a fractional CO2 laser
(SmartXide DOT, DEKA M.E.L.A., Florence, Italy) with varying energy density (2.07, 2.77 and 4.15 J/cm2). Clinical efficacy
of the said laser irradiation parameters was assessed in all of the subjects, and the skin cytokine profile was studied
by using the immunohistochemistry technique based on skin tissue samples taken prior to the treatment, right after
the treatment and in 3 and 30 days. There were significant improvements in the wrinkle and skin texture condition, and
hyperpigmentation was reduced as a result of the treatment, which proves the efficacy of using the fractional CO2 laser
for the skin photorejuvenation. The technique ensures good clinical results and is distinguished by a short rehabilitation
period and excellent safety profile. In the course of the immunohistochemistry, a relation between the skin cytokine
production, reepithelization and laser irradiation density was established.
Specialized teenager centers for prevention and treatment of sexually transmitted infections: resultsof operations and prospects of development
Authors: Rakhmatulina M R , Vasil'eva M Yu , RAKHMATULLINA M R , VASILIYEVA M YU
Published: February 2022

The authors describe an experience of organizing specialized centers for teenagers dealing with prevention and treatment
of sexually transmitted infections, cover major principles of rendering medical aid to underage patients suffering from
urogenital infectious diseases, and describe major prevention activities of specialized centers operating in subjects of the
Russian Federation.
Changes in the hormonal status of patients with focal psoriasis vulgaris
Authors: Vasil'ev A G , Zaslavskiy D V , Trashkov A P , Kravtsova A A , Kazikhanova S R , Khayrutdinov V R , Khvedelidze M G , VASILIYEV A G , ZASLAVSKY D V , TRASHKOV A P , KRAVTSOVA A A , KAZIKHANOVA S R , KHAIRUTDINOV V R , KHVEDELIDZE M G
Published: February 2022

Cell differentiation affections substantiate the urgency of the problem related to studying mutual impact of primary or
secondary endocrine pathology and hyperproliferative skin diseases. Psoriasis is one of the most demonstrative pathologies
for this study for being a prevalent and genetically predetermined disease with a chronic and relapsing course characterized
by increased proliferation of keratinocytes, abnormal differentiation process of epidermis cells, inflammatory and immune
changes in derma, and dyshormonal disorders are among factors triggering the disease. The study involved 61 male patients.
The study group (n = 43) comprised patients with circumscribed psoriasis vulgaris at the progression stage while the control
group (n = 18) comprised healthy people. Blood concentration of such hormones as prolactin and cortisone was assessed
by the immune-enzyme assay method. An increased cortisone concentration in patients suffering from psoriasis vs. control
group was revealed. Psoriatic patients tend to have an increased prolactin level.
Analysis of the dynamics of the incidence rate for malignant skin neoplasms among the populationresiding in the impact zone of a large-scale nuclear enterprise
Authors: Karpov A B , Zuev A V , Takhauov R M , Kostrykina E V , Kalinkin D E , Samoylova Yu A , KARPOV A B , ZUYEV A V , TAKHAUOV R M , KOSTRYKINA YE V , KALINKIN D YE , SAMOILOVA YU A
Published: February 2022

The study involved an analysis of the dynamics of dermatological and oncological diseases [epithelial malignant skin
neoplasms (С44), malignant skin melanoma (С43)] conducted among the population of the town of Seversk in 1970-
2009. A growth in the incidence rate of malignant skin neoplasms in 2000-2009 was revealed; it was established that
such data exceed similar indices for the Tomsk region
Correlation of polymorphisms in genes coding cytokines TNF-α, IL-10, MBL2, IFN-γ and IL-6 with complicated course of urogenital chlamydial infection in men
Authors: Popov D V , Rakhmatulina M R , Frigo N V
Published: February 2022

Goal. To develop a personified approach to the management of men with the urogenital chlamydia infection based on studying the molecular and genetic risk factors of the development of complications. Materials and methods. Patients with the urogenital chlamydia infection (20 men with the urogenital chlamydia infection of the lower urogenital tract and 20 men with complicated forms of the urogenital chlamydia infection) and men without any clinical or laboratory signs of STDs and inflammatory diseases of the urogenital tract. The following methods were used in the study: anamnestic, clinical, instrumental (transrectal ultrasonography) and laboratory (microscopic, bacteriological, molecular and biological (PCR, SNaPshot)). Results. According to the study results, the share of cases of ureteritis caused by C. trachomatis amounted to 10.5% of the total share of cases of ureteritis and 13.0% of cases of non-gonococcal ureteritis. The percentage of complicated urogenital diseases caused by C. trachomatis amounted to 34.5% of the total share of complicated forms and 35.7% of noncomplicated forms of the non-gonococcal origin. Subjective clinical signs of complicated forms of the chlamydia infection did not have any reliable distinctions from those observed in case of non-complicated forms of the disease; the infectious process caused by C. trachomatis was characterized by the absence of leukocytosis in the urethra in 30.0% of men with both non-complicated and complicated forms of the disease. The study of the polymorphism of cytokine genes revealed that the CC genotype of IL-6 gene at the -174 locus can serve as a molecular predictor of the complicated course of urogenital chlamydiosis in men while the GC genotype of IL-6 gene at the -174 locus can serve as a molecular predictor of the non-complicated course of urogenital chlamydiosis in men. Based on these results, the authors developed an algorithm for a differential approach to the management of patients suffering from chlamydia infection. Conclusion. A differential approach to the management of men with the urogenital chlamydia infection depending on the molecular predictor of the complicated course of the disease was developed.
Neurosyphilis: epidemiology, pathogenesis, clinical course and laboratory diagnostics
Authors: KATUNIN G L , MELEKHINA L YE , FRIGO N V
Published: February 2022

The article describes the key achievements and problems related to studying neurosyphilis. It also shows the dynamics of neurosyphilis incidence in Russia and abroad from the early twentieth century and up to present. The article also describes issues related to the pathogenesis, clinical course and pathomorphism of the disease. The authors present current approaches to the laboratory diagnostics of neurosyphilis.
Current approaches to the treatment of vulvovaginitis caused by opportunistic microorganisms taking into consideration the antibacterial resistance of infectious agents
Authors: Rakhmatulina M R
Published: February 2022

Goal of the study. To study the qualitative and quantitative composition of the vaginal microcenosis in women of childbearing potential with vulvovaginitis and determine the sensitivity indices of opportunistic microorganisms being etiological agents of vulvovaginitis concerning antibacterial drugs. Materials and methods. Samples of the vaginal fluid obtained from 264 women (198 patients with clinical and laboratory signs of vulvovaginitis and 66 clinically healthy women) as well as 190 isolates of opportunistic microbial agents were analyzed with the use of microscopic and cultural methods as well as polymerase chain reaction. Results. The authors determined the composition of the vaginal microbiocenosis in women suffering from vulvovaginitis characterized by the prevalence of Corynebacterium spp., E. coli, E. faecalis, S. saprophiticus, K. pneumoniae, S. anginosus, S. agalactiae in the amount exceeding 10 2—10 4 CFU/ml and in associations of four or more microorganisms. The authors revealed that opportunistic microorganisms had the highest sensitivity to amoxicillin/clavulanic acid, nitrofuran and ceftriaxone.
UVA-1 therapy of localized scleroderma and other diseases accompanied by skin sclerosis
Authors: VOLNUKHIN V A , SAMSONOV V A
Published: February 2022

The study results confirm the efficacy of the UVA-1 therapy for patients with localized scleroderma, extragenital lichen sclerosus et atrophicus, sclerodermatous chronic graft-versus-host disease and scleredema adultorum. The therapy has an anti-inflammatory and anti^m^ action, arrests progression and reduces the activity of the disease process, and has a good efficacy and safety profile.
Influence of combined drug tiladerm on the course of allergic contact dermatitis in rats
Authors: SMIRNOV V S , SAVATEEVA-LJUBIMOVA T N , SAVATEEV A V
Published: February 2022

Materials and methods. The composition of glyzyrrhizic acid and glutamyl-tryptophane in the form of cream was studied using white rats. ACD was induced by application of the ethanol-acetone solution of 2,4-dinitrochlorobenzene (DNCB) during 4 days. The investigational drug was applied to the ACD lesions once a day during 14 consecutive days. The severity of ACD was assessed by the condition of the lesion focus, morphological composition of blood and apoptosis rate in the lesion. Results. It was shown that 4 days application of DNCB causes typical skin lesion manifesting in local papulovesicular eruptions, excoriations, and forming crust on the surface of the lesion. Application of the topical drug Tiladerm in the form of cream on the lesion induces significant acceleration of the lesion focus rehabilitation as early as on the end of 14 day of treatment. The activation of the markers of apoptosis (Ki-67, to a less extend p-53, caspase-3, Bcl-2) in the ACD lesion was shown. During treatment with Tiladerm, Ki-67 expression was reduced while expressions of p-53 and caspase-3 were enhanced. Conclusion. Thus, Tiladerm showed prominent positive effect on experimental ACD in rats.
Different drug forms of methylprednisolone aceponate for the treatment of patients with allergic skin diseases
Authors: KUNGUROV N V , KOKHAN M M , KENIKSFEST YU V , STUKOVA YE I , KORYUKINA YE B , VEDERNIKOVA S V
Published: February 2022

The article presents the results of the efficacy and safety assessment of the treatment of adult patients suffering from allergic dermatoses with different drug forms of methylprednisolone aceponate 0.1% (Advantan). The authors revealed high efficacy of the treatment of patients with atopic dermatitis and generalized eczema with the achievement of clinical remission and regression of the EASI index by 88.6-88.8% from the baseline level after three weeks of the drug administration; in patients with hand eczema after four weeks of treatment, and in patients with allergic dermatitis - after external treatment with methylprednisolone aceponate (MPA) 0.1% for two weeks; the patients' life quality improved after the treatment. Four weeks after the completion of the treatment, the skin of all the patients was nearly free from any eruptions while itching was negligible or absent. The efficacy of the differential administration of different drug forms of MPA 0.1% (Advantan) was demonstrated to localize eruptions in problem areas, on the skin in the area of the body and limbs, and according to particular features of clinical manifestations of dermatoses. The authors confirmed the safety of MPA 0.1% (Advantan) for the treatment of patients with allergic dermatoses as well as absence of any adverse effects in patients with AD, generalized eczema, hand eczema and allergic dermatitis within the aforesaid terms.
The impact of intradermal injections of modified hyaluronic acid on the morphological skin condition in female patients with involutional changes
Authors: MIKHAILOVA N P
Published: February 2022

Goal. To provide a clinical assessment of the efficacy and tolerance of hyaluronic acid (HA) drugs modified with vitamin С and amino acids in patients with involutional skin changes. Methods. As many as 90 female patients underwent a course of treatment for age-related skin changes including three procedures of intradermal injections of modified HA. The skin condition was assessed prior to and after the treatment by using non-invasive methods (corneometry, pH-metry, sebometry, elastometry, visio-scanning, ultrasonic derma-scanning and confocal laser scanning microscopy). Results. The authors demonstrated good tolerance of modified HA and skin condition improvement (better elasticity, moisture level, improvement of the skin structure and microrelief, reduction in the intensity of expression and static wrinkles, restoration of color uniformity and elimination of xerosis manifestations). Conclusion. The study results are sufficient to recommend modified HA drugs for correcting involutional skin changes.
Diagnostics and treatment of erythema chronicum migrans Aftselius Lipschutz in a female patient with localized scleroderma under the condition of daytime hospital
Authors: Butareva M M , Znamenskaya L F , Muradyan N L , Brezgina O V , Afromeyeva D M
Published: February 2022

The authors describe a case study of the primary stage of the Lyme disease erythema chronicum migrans in a female patient suffering from localized scleroderma. They review principal pathogenetic mechanisms of the onset and potential ethiological relationship between the Lyme disease (borreliosis) and localized scleroderma.
Treatment of localized scleroderma with hyaluronidase
Authors: Dvornikov A S
Published: February 2022

Goal. To evaluate the efficacy of treatment of patients suffering from localized scleroderma with Longidaza. Materials and methods. The study sample included 300 patients with localized scleroderma (158 with the plaque form and 142 with white spot disease) treated with Longidaza in 2002—2010. Results. Complex therapy of patients suffering from localized scleroderma with Longidaza proved to be efficient in 71.3% of the patients. Conclusion. These results confirm that inclusion of the Russian enzymatic drug Longidaza into the complex treatment of patients suffering from the aforesaid pathology seems to be expedient.
Rational external therapy of scalp psoriasis
Authors: Perlamutrov Yu N , Olkhovskaya K B
Published: February 2022

Scalp psoriasis results in evident cosmetic defects and is refractory to treatment. The therapy for scalp psoriasis using the Elocom lotion results in a prompt and evident clinical effect while its further intermittent application prevents relapses without the onset of adverse events and adrenal cortex dysfunction.
Current topical therapy of psoriatic patients suffering from scalp lesions
Authors: FILIMONKOVA N N , TOPYCHKANOVA YE P
Published: February 2022

Scalp lesions reduce the life quality of psoriatic patients. Goal. to assess the efficacy and safety of the topical therapy of psoriatic patients suffering from scalp lesions using a combination gel containing betamethasone and calcipotriol. Materials and methods. As many as 32 psoriatic patients suffering from scalp lesions received treatment. The clinical assessment was conducted using the PASI index. The Dermatology Life Quality Index (DLQI) was used to assess the patients’ life quality. Results. A reliable reduction in the PASI (by 69.9%) and DLQI (fivefold) indices was observed in most of the patients. No adverse effects or complications were observed as a result of the topical therapy of psoriatic patients with the gel containing betamethasone and calcipotriol. Conclusion. High efficacy and safety of the treatment method were observed.
Experience of effective treatment for patients with severe psoriasis
Authors: KUNGUROV N V , ZILBERBERG N V , KOKHAN M M , KENIKSFEST J V , ZASADKEVICH J M
Published: February 2022

In this study was summarized the clinical monitoring of 6 patients with a vulgar severe psoriasis receiving a short course of Ustekinumab — antagonist of IL 12/23. Clinical monitoring demonstrated high efficiency of treatment with achievement of clinical remission and appreciable improvement in all patients; conservation of remission of psoriasis process till 6 months with regress of PASI more than 75 % from initial point in 5 from 6 patients; improvement of quality of life, absence of complications and adverse events during the treatment and the subsequent observation.
Current approaches to the external therapy of psoriasis
Authors: KHLEBNIKOVA A N
Published: February 2022

Topical glucocorticosteroids rank first among drugs for the external therapy of psoriasis. When selecting a drug, it is necessary to take into account the disease sensitivity to different classes of topical steroids. Dermovate (clobetasol propionate) is the most efficient drug for the external therapy of moderate to severe psoriasis. When this drug was used as a part of the complex treatment of psoriasis, regression of eruptions was observed within three weeks in 97.4% of patients, and in 91.5% of patients if the process was localized in the area of palms and soles. Major indications for its use are torpidity with regard to the previous therapy, localization in the field of palms and soles, and substantial reduction in the life quality.
Experience of molecular typing and phylogenetic analysis of N. gonorrhoeae strains in the Russian Federation
Authors: Solomka V S , Chuprov-Netochin R N , Frigo N V , Kubanov A A
Published: February 2022

The article presents results of the molecular typing and phylogenetic analysis of N. Gonorrhoeae strains in the Russian Federation conducted based on a large sample of N. Gonorrhoeae strains. A considerable genetic variety of N. Gonorrhoeae strains circulating in the territory of the Russian Federation was revealed, which can serve as an evidence of a high rate of accumulation of por and tbp gene mutations among the Russian population of N. Gonorrhoeae strains. The authors established the genetic relationship between individual sequence types of N. Gonorrhoeae strains, and revealed total and dominating sequence types of N. Gonorrhoeae strains found both in different territories of the Russian Federation and abroad, which confirms that such strains can be transferred between different territories of the Russian Federation and from abroad due to active migration of population.
Selection of the therapy of herpes viral infection based on the data of the monitoring of the sensitivity of the herpes simplex virus to etiotropic drugs
Authors: Alimbarova L M , Lazarenko A A , Barinsky I F
Published: February 2022

The authors present the results of the monitoring of the sensitivity of herpes simplex virus (HSV) strains in vitro isolated from 110 female patients with various forms of the herpes virus infection to etiotropic drugs (acyclovir (ACV)), valacyclovir) based on the data provided by the phenotypic method. The authors established that 90% of HSV strains were sensitive to ACV irrespective of the isolation conditions, and the share of non-sensitive strains was 10% while the share of strains that were not sensitive to valacyclovir was not higher than 0.9%. These data are of great value for the evaluation of the pathological process activity, forecast for the disease and selection of an individualized treatment regimen for patients providing for the selection of an antiviral drug and its optimum dose in view of the results of virology studies.
Disseminated miliary lupus of the face as a rare form of skin tuberculosis: a clinical observation
Authors: Tush M M , Gluzmin M I , Kartashevskaya M I , Sycheva N L
Published: February 2022

The article describes a clinical observation of a rare form of skin tuberculosis - disseminated miliary lupus of the face.
On the results of an open-label single-arm study to evaluate the efficacy, safety and tolerability of acnecutan in patients suffering from severe forms of acne as well as acne resistant to other therapies
Authors: Danilova A A , Kosorukova I M
Published: February 2022

Goal: evaluation of the efficacy and safety of acnecutan in patients with severe forms of acne or if other acne treatment methods prove to be inefficient. Materials and methods: the study involved 35 patients with severe forms of acne and acne resistant to other therapies. The patients received a monotherapy with acnecutan. The efficacy and safety of this therapy were evaluated at each visit judging by the clinical picture of the disease; the severity of the disease was defined based on the count of components (such as comedones, papulopustules, nodes, dyschromias and scars). The safety of the drug was assessed based on the data on adverse and unforeseen events taking into account subjective (patient’s complaints) and objective (total blood count, urine test, blood biochemistry) indices. Results: against the background of the course of treatment with acnecutan, all patients who participated in the study clinical achieved remission. Conclusion: acnecutan is a highly efficient drug for the treatment of severe forms of acne or acne resistant to other treatments.
Genetic variations of C. trachomatis and search of virulence factors
Authors: PLAKHOVA K I , KOZHUSHNAYA O S , RAHMATULINA M R , FRIGO N V
Published: February 2022

Represents results of research, dedicated to the search of genetically determined factors of С. trachomatis virulence. Data of papers, studying features of С. trachomatis genetic variations was highlighted.
Role of CD11c-positive dendrite cells in the psoriasis pathogenesis
Authors: HAIRUTDINOV V N
Published: February 2022

The immune response, developing with psoriasis relapse, starts from the concentration of activated myeloid dendrite cells, being the main source of the necrosis factor of α -tumor in the area of originating papula. Target: studies of the number of sub-populations of dendrite cells in skin of patients, suffering from psoriasis in different periods of the disease. Маterial and methods. Skin biopsy samples of 43 patients, suffering from psoriasis vulgaris and skin biopsy samples of 16 healthy people have been studied. The skin immunohistochemistry with use of anti-CD11c, CD83 and CD3 аntibodies was performed. Results. The number of CD11c+ and CD83+ dendrite cells in the skin of patients, suffering from psoriasis in the progressing period was 11,2 and 7,8 times more than in the skin of healthy individuals and 3,0 and 2,4 times more than at patients, suffering from psoriasis during remission accordingly. Opinions. In the skin of patients, suffering from psoriasis, during remission at the place of the delivered psoriatic papule the number of CD83+, CD11c+ dendrite cells and CD3+ lymphocytes exceeds its number in the healthy skin, and the ratio of these cells and its localization in the lesion focuses differ from the skin of healthy people.
Volf’s isotopic response
Authors: BOROVIKOV Y E , BUKIN Y K
Published: February 2022

The term of “isotopic response” was offered by R. Wolf and co-authors in 1995 and means the development of the new dermatosis at the place of already existing initial one, which has already regressed and is not directly referred to the first one. The article describes the essence of the phenomena and most important clinical cases. Such pathogenic mechanisms as viral, immunologic, vascular, neurogenic theory are being discussed, as well as the immunocompromised site concept. The commonality and the difference of the isotopic response and of the isomorphic Kobner’s phenomenon are being analyzed. Two clinical cases are provided.
Demodex mites and Malassezia yeast at patients with seborrheic dermatitis
Authors: MOKRONOSOVA M A , GLUSHAKOVA A M , GOLYSHEVA E V , ZHELTIKOVA T M
Published: February 2022

Target. Studies of dynamics of species diversity and of abundance of Malassezia fungi, аs well as of pimple mites at the skin of patients, suffering from seborrheic dermatitis (SD) at the treatment with activated zinc pyrithione aerosol (ZPA). Маterial and methods. 60 patients with SD were examined. 2 groups were segregated: 1-st (n = 31) - patients with SD, receiving within 4 weeks the AZP therapy; 2-nd (n = 29) - patients with SD, not receiving local therapy. At the examination the gravity of symptoms, the dynamics of skin integument affection was assessed, the mycological skin analysis for Malassezia fungi, as well as the acarological analysis for Demodex mites was performed. Results. 4 kinds of Malassezia were revealed on the skin of patients, suffering with SD disease, with dominating M. globosa (10 7 КОЕ/cm 2). At patients, suffering with SD, 2 kinds of mites were revealed: Demodex: D. brevis and D. folliculorum. D. Brevis was dominating - 65%, D.folliculorum - 26%. After affected sites of the facer skin of patients, suffering from SD, with AZP aerosol within 4 weeks was revealed the statically authentic decrease at the average by a factor of 2 from the number of Malassezia yeast, and the decrease (to 16%) of the frequency of D.brevis reveal, аs well as the complete elimination of D.folliculorum. After the course of therapy with topical AZP aerosol is over the high therapeutic effect is revealed at 90% patients with SD. Opinion. So, AZP aerosol can be recommend to the decrease of the number of Malassezia fungi at Demodex mites at the facial skin of patients, suffering with SD.
Immune predictors of complications of the urogenital chlamydial infection leading to infertility
Authors: PLAHoVA K I , Frigo N V , RAHMATULINA M R , ROTANOV S V , HAYRULLIN R F
Published: February 2022

Goal: determination of immune predictors of the development of complications of the urogenital chlamydial infection (UGCI) in women and further disorder of the reproductive function (infertility) due to the past infection. Маterials and methods. 80 women have been examined: 40 patients with uGCI (20 — with UGCI of lower sections of the urogenital tract and 20 — with pelvic UGCI), 20 patients with secondary (tubal) infertility with the previous UGCI in the anamnesis and 20 clinically healthy women. The qualitative and quantitative study of the spectrum of cytokines (IL-2, -4, -6, -8, -10, INF-γ, TNF α and GM-CSF) with the use of the хМАР multiplex technology in blood and the cervical secretion. Results. The research has determined the spectrum of cytokines with a change in their concentration having an effect on the outcome of UGCI and the development of complications causing disorders of the reproductive function in women: these are TNF-α, IFN-γ, IL-2 inflammatory cytokines аs well as the IL-10 inflammatory cytokine.
Therapeutic possibilities for the correction of damages of dry skin barrier features
Authors: BELOUSOVA T A , GORYACHKINA M V
Published: February 2022

Provides the modern data about barrier features of the skin and of structures, providing such features. Key pathologic mechanisms, serving the basis for the skin barrier diseases, are being considered. Data on external and endogenous factors, causing the skin barrier breach, as well as on clinical features of the skin xerosis is given. Recommendations on the basic care for the dry xerotic skin, using Xemoz cosmeceuticals, as independent therapy, as well as combined with other pharmaceuticals, are highlighted.
Mechanisms of the formation of Neisseria gonorrhoeae resistance to cephalosporins
Authors: KOZHUSHNAYA O S , VASILIYEVA YE L , FRIGO N V , SOLOMKA V S
Published: February 2022

The authors provide a review of the present-day literature data on the issues of studying the mechanisms of the formation of Neisseria gonorrhoeae resistance to third-generation cephalosporins. Studies in this field are needed in connection with the occurrence of strains resistant to third-generation cephalosporins as well as low-sensitivity strains. The authors emphasize the importance of mutations in porB, penA, mtrR, penB and ponA genes in the development of Neisseria gonorrhoeae resistance to β-lactam antibiotics and describe the prospects of studying the mosaic structure of the penA gene encoding the РВР2 protein as well as spatial structure of this protein.
Anti-inflammatory effect of basic care liposomal drugs in case of dermatoses associated with dry skin
Authors: KRINITSYNA YU M , SERGEYEVA I G , ONIPCHENKO V V , GVOZDAREVA M A
Published: February 2022

Objective. To analyze the clinical and morphological changes in the skin in case of inflammatory dermatoses when Aisida, a cream gel for dry and sensitive facial and body skin, is used as a monotherapy. Materials and methods. Aisida, a cream gel for dry and sensitive facial and body skin with the ASD concentration of 0.05%, was used as the first-line treatment for dermatoses in 72 patients with dry skin as the key factor of dermatosis pathogenesis (atopic dermatitis, eczema against the background of xerosis, retinoid dermatitis against the background of a system therapy with isotretinoin). In order to visualize the structure of epidermis, derma and hypoderm, the authors used the ultrasonic skin scanning method at the frequency of 75 M Results. The authors demonstrated high clinical efficiency of the drug. Skin scanning images confirmed the evident effect of the Aisida cream gel on the dermal acoustic density.
Necrobiosis lipoidica (Oppenheim — urbach disease)
Authors: PLATONOVA A N , BAKULEV A L , SLESARENKO N A , MORRISON A V , SHABOGINA A A , DAVYDOVA A V
Published: February 2022

Etiology, pathogenesis, clinical and pathomorphological criteria of diagnostics of necrobiosis lipoidica are described. The case of own supervision is presented.
Inhibitors of tumor necrosis factor-alpha for treatment ofpsoriatic patients
Authors: Znamenskaya L F , Znamenskaya L F
Published: February 2022

The article describes current concepts of the role of cytokines in the pathogenesis of inflammatory diseases. The authors describe
the biological action of tumor necrosis factor-alpha and its soluble receptors on body cells. They also provide data on the role
of tumor necrosis factor-alpha in the formation of skin and joint inflammatory affections at psoriasis. The authors substantiate
treatment of medium to severe forms of psoriasis with biological gene-engineered anti-cytokine drugs, and provide and their
comparative characteristics.
Internet as a source of information on sexual and reproductive healthfor teenagers
Authors: Rakhmatulina M R , Vasil'eva M Yu , Rakhmatulina M R , Vasiliyeva M Yu
Published: February 2022

The article presents the results of Russian and foreign studies on using the Internet as an information source for teenagers about
sexually transmitted infections. The possibility to revive the primary prevention system to fight sexually transmitted infections has been discussed, and quality criteria for present-day medical resources have been examined.
Etiology and treatment of circumscribed sclerodermarevisited
Authors: Dvornikov A S , Kruglova L S , Dvornikov A S , Kruglova L S
Published: February 2022

There was a clinical and laboratory study of the efficacy of complex treatment with Longidaza, a Russian enzyme drug, in 30
patients suffering from circumscribed scleroderma. High efficacy of treatment for different clinical forms of circumscribed scleroderma
using this method was proved. A positive effect of the complex therapy on the results of ultrasonic skin examination in the
affection foci and individual blood immunology indices was revealed.