bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Study between the Laryngeal Mask Airway and Endotracheal Tube on Haemodynamic Changes for Laparoscopic Cholecystectomy Under General Anaesthesia
Authors: Hasan Mahbubul , Rahman Md Mushfiqur , Ekramullah Mahmud , Shaheen Shafiul Alam , Jabbar Abdul , Islam Md Rashedul
Published: May 2023

Background: Evidence based data in the very recent years suggest that in spite of tremendous advances in contemporary anaesthetic practice and advances, airway management continue to be of paramount importance to anaesthesiologists and data regarding the outcomes of use of LMA (laryngeal mask airway) in contrast to ETT (endotracheal tube) are scanty in our clinical setup.
Aims & Objectives: In this RCT (Randomized Control Clinical Trial), the ultimate aim was to depict the anaesthetic safety and haemodynamic changes of use of LMA in contrast to ETT for the patients of routine laparoscopic cholecystectomy (ASA II & III).
Methods and Materials: This randomized control clinical trial (RCT) was conducted in BIRDEM General Hospital, Dhaka, Bangladesh with a total number of 60 patients (30 patients with endotracheal tube & 30 patients with LMA) were selected on the basis of systemic random sampling. The haemodynamic changes, oxygenation, ventilation and intraoperative and postoperative laryngopharyngeal complication (LPM) were noted.
Results: The ultimate result of this study suggest that in Group A (ETT group), mean±SD of age was 48±1.9 and in Group B (LMA group), it was 52±1.7. Demographic status suggests that the average BMI in both group were 28.9 and 30.6 respectively. In ETT group, majority of patients (69%) had ASA grade II, in contrast, in LMA group, it was 52%. Average anaesthetic duration in both group were 45 & 50 minutes respectively. There found significant difference in haemodynamic parameter during Intubation and LMA insertion. There were no statistically significant differences in oxygen saturation (SpO2) between the two groups before or during peritoneal insufflation. Laryngeal complications, like coughing and vomiting following removal of tube were found in 6.7% and 3.3% patients respectively with the use of LMA. No case of tube leak, gastric insufflation, regurgitation, aspiration, trauma to lip, teeth, tongue, dysphagia, dysphonia and dysarthia was recorded. P-values suggests statistically insignificant result here (>0.05).
Conclusion: The effectiveness and safety of LMA in terms of intra and postoperative haemodynamic status, SaO2 and laryngeal complications are clinically comparable to those of endotracheal tube. And LMA insertion causes less changes of haemodynamic parameters when compared with that of ET intubation. Our finding suggests that LMA can be safe and beneficial alternative to ETT.
JBSA 2017; 30(1): 34-40
Ephedrine versus Phenylephrine: Prevention of Hypotension during Spinal Anaesthesia for Cesarean Section and Effects on the Fetus
Authors: Haque M Masudul , Aleem Mohammad Abdul , Hossain Pervez Altaf , Siddique Md Abu Baker , Islam Atiqul
Published: May 2023

Background: Hypotension during spinal anaesthesia for cesarean section is secondary to the sympathetic blockade and aorto-caval compression by the uterus and it can be deleterious to both the fetus and the mother. Ephedrine and phenylephrine improve venous return after sympathetic blockade during the spinal anaesthesia.
Aim: The aim of this study was to compare intravenous bolus doses of phenylephrine and ephedrine in preventing and treating hypotension in spinal anaesthesia for caesarean section and the effect of vasopressors on fetal outcome in terms of Apgar score.
Materials and Methods: Total 100 patients of ASA Grade I undergoing caesarean section under spinal anaesthesia with a normal singleton pregnancy beyond 37 weeks gestation was randomly allocated into two groups of 50 each. Group I received prophylactic bolus dose of ephedrine 10 mg IV at the time of intrathecal block with rescue boluses of 5 mg. Group II received prophylactic bolus dose of phenylephrine 100 ¼g IV at the time of intrathecal block with rescue boluses of 50 ¼g. Hemodynamic variables like blood pressure and heart rate was recorded every 2 minutes up to delivery of baby and then after every 5 minutes. Neonatal outcome was assessed using Apgar score at 1 and 5 minutes and neonatal umbilical cord blood pH Values.
Results: There was no difference found in managing hypotension between two groups. Incidence of bradycardia was higher in phenylephrine group. The differences in umbilical cord pH, Apgar score, and birth weight between two groups were found statistically insignificant.
Conclusion: Ephedrine and Phenylephrine are equally efficient in managing hypotension during spinal anesthesia for caesarean section. There was no difference between two vasopressors in the incidence of true fetal acidosis. Neonatal outcome remains equally good in both the groups.
JBSA 2017; 30(1): 41-47
Associations between Orbital Morphology and Exophthalmos Changes after Endoscopic Orbital Decompression to Treat Thyroid-related Orbitopathy
Authors: Lee Jun Seob , Kang Sung Mo
Published: May 2023

Purpose: To investigate orbital morphology parameters associated with exophthalmos changes in patients undergoing endoscopic orbital decompression to treat thyroid-related orbitopathy.Methods: In total, 33 eyes of 18 patients with thyroid-related orbitopathy who underwent endoscopic orbital decompression were included in this retrospective study. Data were collected before and 6 months after surgery. We performed Hertel exophthalmometry and derived orbital morphology parameters from two-dimensional facial computed tomography records. Parameters associated with exophthalmos reduction on univariate linear regression analysis were subjected to multivariate linear regression analyses.Results: Univariate linear regression showed that the preoperative length of the medial orbital wall (β = 0.179, p = 0.032) and the postoperative distance from the cone apex to the medial wall defect (β = -0.139, p = 0.006) were associated with exophthalmos reduction after endoscopic orbital decompression surgery. Multivariate linear regression of these two parameters showed that the distance from the apex to the medial wall defect was associated with exophthalmos reduction (β = -0.118, p = 0.019).Conclusions: The postoperative distance from the cone apex to the medial wall defect was associated with exophthalmos reduction. In patients with thyroid-related orbitopathy, this association should be considered when planning endoscopic orbital decompression.
Effect of Loose Masks on Tear-film Break-up Time
Authors: Lee Jooheon , Ahn Minwon , Choi Jaewon , Park Minji
Published: May 2023

Purpose: We investigated the the effect of wearing a loose mask on tear-film break-up time using cross-sectional and experimental methods.Methods: This was a comparative analysis of non-invasive tear-film break-up time (NIBUT) after wearing no mask, loose mask, and tight mask for 10 minutes each in 60 eyes with or without dry eye syndrome. NIBUT measurements were performed using a keratograph.Results: The NIBUT values were 7.53 ± 0.83 seconds, 6.19 ± 0.78 seconds, and 7.36 ± 0.68 seconds for the no mask, loose mask, and tight mask groups, respectively. There was no significant difference between the no mask and tight mask groups (ρ-value = 0.517), but the loose mask group had a significantly reduced NIBUT compared with the other groups (ρ-value = 0.013 and 0.022, respectively).Conclusions: Wearing a loose mask reduced the tear-film break-up time regardless of the presence or absence of dry eyes and may cause or worsen dry eye symptoms.
Efficacy of Biometry Using Swept-source Optical Coherence Tomography for Posterior Chamber Phakic Intraocular Lens Implantation
Authors: Jo Min Soo , Moon Ja Yoon , Chung Sung Kun , Kim Eung Kweon , Park Kyu Hong , Choi Jin Seok
Published: May 2023

Purpose: The proper implantable collamer lens (ICL) size affects ICL stability. This study compared device efficacy using white-to-white diameter (WTW) measurements with Orbscan II and IOL Master 700.Methods: We retrospectively studied 90 eyes (45 patients) who underwent toric ICL implantation from January 2019 to February 2020 and were followed for 1 year. The correlation between WTW and anterior chamber depth (ACD) for each measuring device was analyzed.Results: The mean WTW measured by IOL Master 700 and Orbscan II was 12.2 ± 0.3 and 11.6 ± 0.3 mm, respectively, while the mean ACD was 3.28 ± 0.16 and 3.20 ± 0.15 mm. The WTW and ACD measured with IOL Master 700 averaged 0.57 ± 0.12 and 0.08 ± 0.04 mm larger than with Orbscan II. The differences were significant and the regression analysis had high correlations (R2 = 0.875 and R2 = 0.913, respectively; both p < 0.001).Conclusions: WTW measured by the IOL Master 700 can be used as a reference either alone or together with the Orbscan II value to determine ICL size.
Clinical Characteristics of Pediatric Dermoid Cyst Patients
Authors: Kweon Ji-Min , Lee Ju-Yeun , Kwon Ji-Won
Published: May 2023

Purpose: The characteristics of pediatric dermoid cyst patients.Methods: This was a retrospective chart review of 64 dermoid cyst patients (65 eyes) aged < 18 years.Results: Limbal dermoids and conjunctival dermolipomas were observed in 49 and 16 eyes (48 and 16 patients), respectively. Limbal dermoids were more common in the left eye (61%), particularly on the inferotemporal side (80%). Three (6%) of the patients were diagnosed with Goldenhar syndrome. The horizontal diameter (3.76 ± 1.30 mm) was greater than the vertical diameter (3.74 ± 1.30 mm). Most of the lesions were yellow (35.2%) in color, mildly elevated (n = 19, 55.9%), and not visible when the eyes were closed. The mean best corrected visual acuity was 0.8 ± 0.2 in 23 patients, with mean astigmatism and mean corneal astigmatism values of -2.1 ± 2.2 diopters (D) and -2.0 ± 1.1 D, respectively. None of the conjunctival dermolipoma patients had any ocular history. The left eye (75%), particularly the temporal and superiotemporal conjunctival fornix, was the most commonly affected site. The mean best corrected visual acuity was 0.9 ± 0.0 in seven patients, with an average astigmatism of -0.3 ± 0.2 D.Conclusions: Dermoid cysts are congenital benign tumors that may be associated with congenital diseases. They vary in size, location, color, and extent of invasion, and may cause functional problems, such as astigmatism and amblyopia. Therefore, timely surgical treatment is desirable.
Reliability of the Non-contact TONO-i Tonometer Compared with the Goldmann Applanation Tonometer
Authors: Kim Ji Ho , Han Jong Chul
Published: May 2023

Purpose: The accuracy and agreement of intraocular pressure (IOP) measurements using a noncontact self-measuring tonometer, TONO-i, compared with the Goldmann applanation tonometer (GAT).Methods: A total of 35 healthy participants and 42 primary open angle or normal tension glaucoma patients were enrolled in this study. TONO-i and GAT measurements were obtained and the mean difference in IOPs was analyzed using a paired t-test. IOP agreement was calculated using the two-way random effects model. Bland-Altman analysis and simple linear regression were used to estimate the disagreement between IOP measurements.Results: The mean IOPs measured using the TONO-i and GAT were 15.9 ± 3.3 mmHg and 16.4 ± 5.1 mmHg, respectively. In glaucoma patients, the mean values measured using the TONO-i (16.7 ± 4.1 mmHg) were lower than those measured using the GAT (17.9 ± 6.1 mmHg; p < 0.001). However, there was no significant difference among the healthy participants (p = 0.273). The intraclass coefficients (95% confidence interval) for all participants, normal participants, and glaucoma patients were 0.847 (0.702-0.920), 0.882 (0.804-0.941), and 0.828 (0.742-0.887), respectively, indicating good agreement between the IOP measurements. The mean difference and limits of agreement were not statistically significant. As IOP increased, the absolute difference between the GAT and TONO-i measurements also increased.Conclusions: The TONO-i, a novel tonometer, may be used reliably for IOP self-measurement and detecting IOP elevations. However, caution must be exercised because of the possibility of underestimating high IOPs.
Short-term Efficacy and Safety of XEN Stent Implantation with or without a Conjunctival Incision
Authors: Moon Ja Young , Nam Jeoung Woo , Sung Mi Sun , Park Sang Woo
Published: May 2023

Purpose: Comparison of the 6-month outcomes of ab externo XEN 45 gel stent implantation with conjunctival resection in Korean glaucoma patients.Methods: From January to May 2021, 43 open-angle glaucoma patients who underwent ab externo XEN stent insertion alone and were followed for more than 6 months were classified into incision (n = 23) and non-incision (n = 20) groups according to the presence or absence of a conjunctival incision and analyzed retrospectively. Qualified or complete success was defined as achieving the personal target intraocular pressure (IOP) with or without medication, respectively.Results: The IOP measured 6 months after surgery decreased significantly in both groups. The number of IOP-lowering drugs required was also reduced. The decrease in IOP after surgery was greater in the non-incision group. Six months after surgery, the qualified success rate was 55% in the non-incision group and 52.2% in the incision group, while the complete success rate was 40% and 8.7%, respectively. During follow-up, 58.1% of the patients underwent bleb needling more than once, and 20.9% underwent additional IOP-lowering surgery, but there was no difference between the two groups.Conclusions: XEN stent insertion helped to reduce IOP and the number of IOP-lowering agents after 6 months regardless of a conjunctival incision. However, to maintain the target IOP, bleb manipulation was required in many cases.
Surgical Treatment of a Large Choroidal Melanoma
Authors: Lee Hansang , Lee Seung Min , Shin Su-Jin , Choi Eun Young , Lee Junwon , Kim Min
Published: May 2023

Purpose: We report successful eyeball-preserving management of a patient with a large choroidal melanoma. We combined partial lamellar sclerouvectomy (PLSU) with ruthenium (Ru)-106 plaque brachytherapy.Case summary: A 48-year-old woman with a history of asthma visited our clinic with a chief complaint of gradual loss of vision at the nasal side of her right eye (best-corrected visual acuity 0.6). Fundus examination revealed a mushroom-shaped, dark choroidal mass 17.1 mm (basal diameter) × 14.2 mm (apical height). There was no evidence of distant metastasis. To remove the tumor while preserving the eyeball, we combined PLSU and simultaneous Ru-106 plaque brachytherapy with the patient under hypotensive general anesthesia. At 6 weeks postoperatively, trans pars plana vitrectomy with silicone oil injection was performed to remove the vitreous hemorrhage and treat the retinal detachment. Intravitreal bevacizumab (Avastin, Genentech Inc., San Francisco, CA, USA) (0.05 mL, 1.25 mg) was injected every 2 months to prevent the development of radiation retinopathy. No residual tumor, recurrence, or distant metastasis was noted during follow-up of 2 years. The patient was stable with no ocular complications at her last visit (2 years postoperatively).Conclusions: Contrary to what we expected and despite the surgical difficulties, PLSU combined with Ru-106 plaque brachytherapy is a useful eyeball-preserving strategy even when encountering a very large choroidal melanoma (diameter > 16 mm and apical height > 10 mm). Such a melanoma was previously believed to be treatable only via enucleation.
A Case of Macular Serous Retinal Detachment after Ahmed Valve Implantation in an Eye with Pachychoroid
Authors: Kim EunAh , Byon Iksoo , Lee Jiwoong
Published: May 2023

Purpose: We report a case of macular, serous retinal detachment associated with hypotony in a patient with pachychoroid disease developing after Ahmed valve implantation.Case summary: A 77-year-old male visited our clinic with uncontrolled intraocular pressure (IOP; 32 mmHg) in his left eye despite maximal tolerable medical therapy. A prolapsed vitreous filled the anterior chamber. Swept-source optical coherence tomography (SS-OCT) revealed that the subfoveal choroidal thickness was about 510 μm, indicating pachychoroid. Vitrectomy was performed to remove the prolapsed vitreous. The IOP remained 32 mmHg 3 weeks after vitrectomy. Ahmed valve implantation was performed and hypotony developed 10 days postoperatively. Choroidal detachment was apparent and SS-OCT revealed macular accumulation of subretinal fluid. The subfoveal choroidal thickness increased to a level beyond the SS-OCT measurement range. Partial tube ligation was performed to treat the hypotony 18 days after Ahmed valve implantation; the IOP decreased to 14 mmHg at 6 weeks postoperatively. The macular, serous retinal detachment disappeared and the subfoveal choroidal thickness fell to the preoperative value.Conclusions: Hypotony after Ahmed valve implantation can manifest as serous retinal detachment under the fovea accompanied by an increase in choroidal thickness in an eye with underlying pachychoroid.
The Importance of State Capacity in the Fight Against Corruption
Authors: Gökce Gülise
Published: May 2023

This study examines the importance of state capacity in the fight against corruption. Corruption is an important problem in the exercise of political power. For this reason, good governance requires the fight against corruption with more transparency in the relationship between the private sector and politicians/administrators, efficient and effective bureaucracy, clear legal frameworks, and strengthening institutions that implement independent power control. In other words, an effective fight against corruption and good governance requires a strong state capacity. State capacity is an important characteristic of statehood. In this context, the execution of the security function of a state -(monopoly) control of the means of violence and effective law enforcement- is a prerequisite for overcoming political and social problems. After all, a state is characterized as a strong state if it can ensure security throughout the country and take and implement political decisions and has capacity to turn public will into action. The argument of the study addresses the meaning and importance of the state capacity in the effective, efficient, and coordinated implementation of public policies and in the fight against administrative and social problems such as corruption.
Hospital Management During the Coronavirus 2019 Pandemic
Authors: Ghaleb Dr. Abdullah
Published: May 2023

Managing a hospital is highly complex due to the broad range of services hospitals deliver to a diverse population, especially during events such as the coronavirus (COVID-19) pandemic. Hospital managers have faced a number of important management challenges during the COVID-19 pandemic. This qualitative study was conducted to explore the perceptions and views of hospital managers of the key challenges facing health care based on their own experience working at a hospital during the pandemic COVID-19. This study adds to the small body of qualitative knowledge on the experiences of the COVID-19 pandemic in public hospitals. The qualitative data was collected through 15 semi-structured interviews using a thematic analysis. Five interviews were conducted via an online program and 10 were conducted face to face. Participants were healthcare professionals including hospital managers, a director of medical services, a director of patients’ affairs, a director of a nursing department, and managers who work directly with COVID-19 cases. The data analysis identified five main themes: namely, health system challenges, organizational challenges, individual challenges, financial challenges, and legal challenges. The findings of this research provide insights about the challenges experienced by hospital managers and provide direction for future improvements in hospitals to overcome these difficulties.
Past Experiences and Current Mindset Reveal Crisis Mechanism and Financial sustainability Insights. Evidences from Albania
Authors: Skenderi Sibora
Published: May 2023

Periodic economic crises have been a well-recorded phenomenon in nations with capitalist economies since the first half of the 19th century. The effects and repercussions of the global financial crisis of 2007 were undoubtedly felt, even in a small nation like Albania. During the crisis, it became evident that traditional policies that stressed macroeconomic stability were insufficient and that bold action by central banks was necessary to offer flexibility in monetary policy regulations and ensure crisis recovery. This article provides a theoretical explanation of the crisis process as well as a discussion of the Bank of Albania's policy decisions made during two separate crises, the Global Financial Crisis and the Covid-19 Pandemic. In order to emphasize the most significant events and interpret the insights in each stage of the financial cycle, this article was undertaken from the perspective of comparison of various timelines. When looking at financial crises from a macroeconomics perspective, the descriptive method is used to analyse the evidence in a country like Albania. The findings of this study highlight the measures made by the Bank of Albania and the government to manage the economic crisis and strive to reduce its long-term repercussions. The purpose of the study is to provide macroeconomic indicator data on the Central Bank of Albania's response to the aforementioned crises in order to aid policymakers in reflecting on the direction of their policies during two separate periods of crisis.
Youth Participation in School Safety Zones Assessment: A Case Study in Indonesia
Authors: Ellizar Estiara , Larastiti Sukma , Bawono Titis Efrindu , Mulyana Windu , Kurniawan Cahyadi
Published: May 2023

The impacts of the Manahan flyover development in front of Junior High School 1 in Surakarta City, Indonesia, increased road safety risks for the students due to poor urban mobility planning. Since its opening in late 2018, there have already been 12 crashes around the flyover, which resulted in two deaths in the two years after the opening. This research aims to assess the school safety zones using the Star Rating for Schools (SR4S) from the International Road Assessment Programme (iRAP) and propose recommendations for safer road infrastructure using a youth participation approach. The students are empowered with capacity building in road safety to be able to map road problems. They were then involved in participatory design to propose safer road infrastructure which met their needs. The SR4S results can influence the government as the decision-makers to provide a safe environment around the Manahan flyover.
Treated chronic hepatitis B is a good prognostic factor of diffuse large B-cell lymphoma
Authors: Park Jeayeon , Chung Sung Won , Lee Yun Bin , Shin Hyunjae , Hur Moon Haeng , Cho Heejin , Park Min Kyung , Youk Jeonghwan , Lee Ji Yun , Lee Jeong-Ok , Yu Su Jong , Kim Yoon Jun , Yoon Jung-Hwan , Kim Tae Min , Lee Jeong-Hoon
Published: May 2023

Background/Aims: Chronic hepatitis B (CHB) is a risk factor for non-Hodgkin lymphoma (NHL). Our recent study suggested that antiviral treatment may reduce the incidence of NHL in CHB patients. This study compared the prognoses of hepatitis B virus (HBV)-associated diffuse large B-cell lymphoma (DLBCL) patients receiving antiviral treatment and HBV-unassociated DLBCL patients.Methods: This study comprised 928 DLBCL patients who were treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) at two referral centers in Korea. All patients with CHB received antiviral treatment. Time-to-progression (TTP) and overall survival (OS) were the primary and secondary endpoints, respectively.Results: Among the 928 patients in this study, 82 were hepatitis B surface antigen (HBsAg)-positive (the CHB group) and 846 were HBsAg-negative (the non-CHB group). The median follow-up time was 50.5 months (interquartile range [IQR]=25.6–69.7 months). Multivariable analyses showed longer TTP in the CHB group than the non-CHB group both before inverse probability of treatment weighting (IPTW; adjusted hazard ratio [aHR]=0.49, 95% confidence interval [CI]=0.29–0.82, p=0.007) and after IPTW (aHR=0.42, 95% CI=0.26–0.70, p<0.001). The CHB group also had a longer OS than the non-CHB group both before IPTW (HR=0.55, 95% CI=0.33–0.92, log-rank p=0.02) and after IPTW (HR=0.53, 95% CI=0.32–0.99, log-rank p=0.02). Although liver-related deaths did not occur in the non-CHB group, two deaths occurred in the CHB group due to hepatocellular carcinoma and acute liver failure, respectively.Conclusions: Our findings indicate that HBV-associated DLBCL patients receiving antiviral treatment have significantly longer TTP and OS after R-CHOP treatment than HBV-unassociated DLBCL patients.
PENGELOLAAN SAMPAH ORGANIK MENJADI PUPUK KOMPOS DI DESA SUMBERSARI
Authors: Naufa Nabila Aulia , Pangestuti Rinda Siaga , Rusham Rusham
Published: May 2023

Garbage is something that is useless and unwanted. Garbage that is not managed properly can cause environmental and health problems. One way to overcome the negative impact of waste is to process community-based waste. Household organic waste needs to be addressed with waste management using simple methods, one of which is composting. The purpose of this service is to increase community knowledge and skills to manage household organic waste into compost. Community service activities were carried out in Hamlet III, Sumbersari Village, Pebayuran District, Bekasi Regency. The composting process was carried out in a 15L composter using EM-4 bioactivator. The results of this service are increasing public understanding of the procedures for making organic compost from household organic waste and increasing public awareness in waste management.
PENTINGNYA PERENCANAAN KEUANGAN SYARIAH DALAM UPAYA MENSEJAHTERAKAN EKONOMI KELUARGA DI DESA PANTAI SEDERHANA
Authors: Syariah Emy , Gunawan Akmal Rizki , Iskandar Tatang
Published: May 2023

Family financial planning in Indonesian society, the majority of which still use traditional concepts in rural areas, especially housewives who are now family financial managers, use funds that are only focused on consumption activities. The lack of public knowledge of sharia-based family financial planning in managing finances for families is still underestimated because they have not paid much attention to the importance of sharia-based financial planning. The implementation of this community service the author uses in the form of community education, namely by providing socialization in order to increase understanding of the people of Pantai Sederhana Village, Muara Gembong District. Implementation of socialization activities that have been held on Thursday, March 9, 2023 at the Simple Beach Village office face-to-face. The socialization began with the provision of material "The Importance of Islamic Financial Planning in Efforts to Prosper the Family Economy". Based on the conclusions above, participants can appreciate the importance of implementing Islamic finance in order to create prosperous financial conditions in the family. The suggestions recommended for further service or the community are to be able to practice directly in the form of training in several sessions to improve the ability to implement prosperous family financial planning to the community.
PELATIHAN TEKNIK PEMASARAN DIGITAL PADA MASYARAKAT DI DESA JAYABAKTI
Authors: Julian Rizky Maulana , Asiah Siti , Marginingsih Ria
Published: May 2023

The purpose of implementing community service is to improve the quality of human resources in understanding digital marketing in the village of Jayabakti. The development of digital marketing is still not well understood by the public because of the lack of directors and training on digital marketing. The method of implementing community service applies socialization and training methods to advance marketing in the Jayabakti Village community. Implementation of community service is carried out with three activities (1) digital marketing outreach, (2) training in marketing techniques through digital media or social media, (3) marketing consulting. The results of community service activities are proven by the level of understanding of the community regarding digital marketing and MSME actors who have started using social media as product marketing.
PELATIHAN METODE IDENTIFIKASI MOTORIK SISWA MENGGUNAKAN TES TGMD-2 DI DESA JAYALAKSANA
Authors: Sulaeman Trio Wibowo , Ekowati Ekowati , Haqiyah Aridhotul
Published: May 2023

The TGMD-2 test is one of the motion development tests developed by Ulirch in 1985. Ulrich D. A. from the School of kinesiology at the University of Michigan, has compiled a test to evaluate 250 basic motor skills (Test Of Gross Motor Development). TGMD-2 tests 12 basic movement skills which are divided into two subtests, namely locomotor and object control. This test is designed to assess the level of basic motor skills in children aged 3-10 years. This test is suitable for elementary school age students 7-10 years. In community service this time using the training method in the form of demonstrations related to the rules, movements and procedures for carrying out the TGMD-2 Test. The main target for this program is sports teachers who work at the Jayalaksana Village Elementary School, Kec. CabangBungin, Bekasi Regency.The purpose of implementing this program is to improve motor understanding of sports teachers through training in methods of identifying motor skills of elementary school students through the TGMD-2 test. The results obtained showed that the teacher representatives from each elementary school in Jayalaksana Village were able to provide good understanding and direction of the TGMD-2 test movements to 6 (six) students who were appointed as demonstrators in the demonstration of the TGMD-2 test movement. So it can be concluded that this Community service activity has an impact, namely being able to increase knowledge and information related to the material and implementation of the TGMD-2 Test for teachers who teach sports, as well as provide knowledge about the importance of motor development for elementary school students in Jayalaksana Village because they have It is the duty and responsibility of a teacher to know the progress of his students.
 
Keyword:Motor Skills, TGMD-2 Test, Sports Teachers
SOSIALISASI PENGEMBANGAN APARATUR DESA DALAM PENGELOLAAN ADMINISTRASI DESA
Authors: Permata Rahmatan Ahmad Putra , Suryani Elvira , Rofieq Ainur
Published: May 2023

The background of this research is the lack of optimality of the Village Head in conducting comprehensive data collection on village officials from various aspects of qualifications, competence, work experience, less than optimal in providing direction and coaching continuously as well as technical trainings to improve skills and job performance to the village apparatus so that what is planned is not optimally achieved and less than optimal in evaluating the results of the performance of village apparatus to achieve the desired results better. The village has developed in various forms so that it needs to be protected and empowered so that it becomes stronger, advanced, independent and democratic so that it can create a strong foundation in carrying out governance and development towards a just, prosperous and prosperous society. Administrative management in Village Government is an obligation that must be carried out. With the formation of good village government administration, good governance will be formed, development will run smoothly and social life will be orderly. A good and correct village administration system will create an orderly administration, that is, it can provide easy data and information for the community and for the village government in making policies.
PENGENALAN TAJWID SEJAK DINI MELALUI METODE BAGHDADI DI DESA KARANGHAUR
Authors: Maulidia Eka , Muis Abdul , Mulyana R. Achmad
Published: May 2023

Reading the Qur'an properly and correctly is one of the most important knowledge that must be possessed by a child from an early age and Muslims as a basis before studying other sciences. read the Qur'an properly in accordance with the science of Tajwid, the law is Fardhu 'Ain. While reading the Qur'an in accordance with the knowledge of Tajweed, the law is Fardhu Kifayah. So, the science of recitation is knowledge of the rules and ways to read the Qur'an as well as possible. Being aware of the importance of tajwid from an early age and even learning tajwid is very important. Along with the development of the times, the Al-Qur'an learning method has developed. The Al-Baghdadi method is a method of learning the Qur'an. This method is done by spelling it out letter by letter, so this method is usually known as the "spelled" or lubi method. This activity aims to improve the process of learning the Koran at TPA Karanghaur village. Through the learning process, especially learning the Koran, it is hoped that students will be able to read the Koran better, be able to know the origin of a letter so that they will better understand every reading of the verses of the Koran that they read every day.
Widescreen Dreams: Growing Up Gay at the Movies
Authors: Horrigan Patrick
Published: May 2023

In 1973, a sweet-tempered, ferociously imaginative ten-year-old boy named Patrick Horrigan saw the TV premiere of the film version of Hello, Dolly! starring Barbra Streisand. His life would never be the same. Widescreen Dreams: Growing Up Gay at the Movies traces Horrigan’s development from childhood to gay male adulthood through a series of visceral encounters with an unexpected handful of Hollywood movies from the 1960s and 1970s: Hello Dolly!, The Sound of Music, The Poseidon Adventure, Dog Day Afternoon, and The Wiz.
The importance of essential fatty acids and their ratios in aquafeeds to enhance salmonid production, welfare, and human health
Authors: Carr Ian , Glencross Brett , Santigosa Ester
Published: May 2023

Long chain polyunsaturated fatty acids (LC-PUFA), namely those from omega-3 (n-3) and omega-6 (n-6) families, are paramount for both fish and human nutrition. Some of these biomolecules cannot be synthesized de novo and must be acquired through the diet, being termed dietary essential fatty acids (EFA). Fish requirements for EFA have traditionally been met through the incorporation of fish oil (FO) in the formulation of aquafeeds. However, with limited supply of FO the aquaculture industry is searching for additional sustainable sources of LC-PUFA. This has significantly shifted the type of ingredients used in aquafeed formulation, namely vegetable oils (VO) deficient in long-chain omega-3, often resulting in imbalanced levels and ratios of fatty acid classes. Such imbalances can negatively affect fish performance and welfare, as well as the levels of health promoting omega-3 LC-PUFA present in fish fillets. Given the relevance that salmonid aquaculture plays in global fish production (principally Atlantic salmon, Salmo salar), as well as its growing role as a source of dietary health promoting omega-3 LC-PUFA for humans, the present review summarizes the scientific knowledge available to date on the dietary requirements for LC-PUFA by salmonids and humans. We discuss the implications of using imbalanced aquafeed formulations upon fish performance and welfare, as well as the subsequent consequences for human nutrition, along with current efforts to replace FO by alternative ingredients such as algal oil (AO) that can safeguard high-quality salmonid products for human consumption.
Accurate and intelligent diagnosis of pediatric pneumonia using X-ray images and blood testing data
Authors: Yao Dan , Xu Zhenghua , Lin Yi , Zhan Yuefu
Published: May 2023

Computer-aided diagnosis (CAD) methods such as the X-rays-based method is one of the cheapest and safe alternative options to diagnose the disease compared to other alternatives such as Computed Tomography (CT) scan, and so on. However, according to our experiments on X-ray public datasets and real clinical datasets, we found that there are two challenges in the current classification of pneumonia: existing public datasets have been preprocessed too well, making the accuracy of the results relatively high; existing models have weak ability to extract features from the clinical pneumonia X-ray dataset. To solve the dataset problems, we collected a new dataset of pediatric pneumonia with labels obtained through a comprehensive pathogen-radiology-clinical diagnostic screening. Then, to accurately capture the important features in imbalanced data, based on the new dataset, we proposed for the first time a two-stage training multimodal pneumonia classification method combining X-ray images and blood testing data, which improves the image feature extraction ability through a global-local attention module and mitigate the influence of class imbalance data on the results through the two-stage training strategy. In experiments, the performance of our proposed model is the best on new clinical data and outperforms the diagnostic accuracy of four experienced radiologists. Through further research on the performance of various blood testing indicators in the model, we analyzed the conclusions that are helpful for radiologists to diagnose.
A metagenome-level analysis of a microbial community fermenting ultra-filtered milk permeate
Authors: Walters Kevin A. , Mohan Geethaanjali , Myers Kevin S. , Ingle Abel T. , Donohue Timothy J. , Noguera Daniel R.
Published: May 2023

Fermentative microbial communities have the potential to serve as biocatalysts for the conversion of low-value dairy coproducts into renewable chemicals, contributing to a more sustainable global economy. To develop predictive tools for the design and operation of industrially relevant strategies that utilize fermentative microbial communities, there is a need to determine the genomic features of community members that are characteristic to the accumulation of different products. To address this knowledge gap, we performed a 282-day bioreactor experiment with a microbial community that was fed ultra-filtered milk permeate, a low-value coproduct from the dairy industry. The bioreactor was inoculated with a microbial community from an acid-phase digester. A metagenomic analysis was used to assess microbial community dynamics, construct metagenome-assembled genomes (MAGs), and evaluate the potential for lactose utilization and fermentation product synthesis of community members represented by the assembled MAGs. This analysis led us to propose that, in this reactor, members of the Actinobacteriota phylum are important in the degradation of lactose, via the Leloir pathway and the bifid shunt, and the production of acetic, lactic, and succinic acids. In addition, members of the Firmicutes phylum contribute to the chain-elongation-mediated production of butyric, hexanoic, and octanoic acids, with different microbes using either lactose, ethanol, or lactic acid as the growth substrate. We conclude that genes encoding carbohydrate utilization pathways, and genes encoding lactic acid transport into the cell, electron confurcating lactate dehydrogenase, and its associated electron transfer flavoproteins, are genomic features whose presence in Firmicutes needs to be established to infer the growth substrate used for chain elongation.
Tau-dependent HDAC1 nuclear reduction is associated with altered VGluT1 expression
Authors: Siano Giacomo , Madaro Giuseppe , Caiazza Maria Claudia , Allouch Awatef , Varisco Martina , Mignanelli Marianna , Cattaneo Antonino , Di Primio Cristina
Published: May 2023

During AD pathology, Tau protein levels progressively increase from early pathological stages. Tau altered expression causes an unbalance of Tau subcellular localization in the cytosol and in the nuclear compartment leading to synaptic dysfunction, neuronal cell death and neurodegeneration as a consequence. Due to the relevant role of epigenetic remodellers in synaptic activity in physiology and in neurodegeneration, in particular of TRIM28 and HDAC1, we investigated the relationship between Tau and these epigenetic factors. By molecular, imaging and biochemical approaches, here we demonstrate that Tau altered expression in the neuronal cell line SH-SY5y does not alter TRIM28 and HDAC1 expression but it induces a subcellular reduction of HDAC1 in the nuclear compartment. Remarkably, HDAC1 reduced activity modulates the expression of synaptic genes in a way comparable to that observed by Tau increased levels. These results support a competitive relationship between Tau levels and HDAC1 subcellular localization and nuclear activity, indicating a possible mechanism mediating the alternative role of Tau in the pathological alteration of synaptic genes expression.
Paneth cell development in the neonatal gut: pathway regulation, development, and relevance to necrotizing enterocolitis
Authors: Yang Jiahui , Shi Yongyan
Published: May 2023

Paneth cells (PCs) are intestinal epithelial cells (IECs) that contain eosinophilic granules, which are located in Lieberkühn crypts. An increasing number of animal and human experiments have indicated that PCs are involved in the progression of a variety of intestinal as well as systemic inflammatory responses including necrotizing enterocolitis (NEC). NEC is an enteric acquired disease with high mortality that usually occurs in premature infants and neonates, however the underlying mechanisms remain unclear. In this review, we summarize the features of PCs, including their immune function, association with gut microbiota and intestinal stem cells, and their mechanism of regulating IEC death to explore the possible mechanisms by which PCs affect NEC.
Bioactive profiling and evaluation of anti-proliferative and anti-cancerous properties of Shivagutika, an Indian polyherbal formulation synchronizing in vitro and in silico approaches
Authors: V. H. Pushpa , Kuruburu Mahadevaswamy G. , M. K. Jayanthi , N. Akshaya Simha , Taha Babakr Abdullatif , Sreenivasan Rajesh , Ramu Ramith , Madhunapantula SubbaRao V.
Published: May 2023

Shivagutika is a polyherbal formulation mentioned in Ayurveda, the oldest system of medicine. The aim of this study was to investigate the anti-breast cancer potential of DCM extract of Shivagutika using MCF-7, MDA-MB-231, and MDA-MB-468. Primarily, various extracts of Shivagutika were prepared and subjected to primary in vitro analysis—total protein, phenolic acid content, and flavonoid content. DCM extract among all the extracts showed the promising results hence, it was subjected to LC-MS/MS analysis to identify the phytochemicals. The same extract was subjected to anti-proliferation assay and anti-cancer assay. It inhibited all the 3 cell lines and increased the activity of Caspase 3, pro-apoptotic protein. Further, to find the potent molecule(s) in silico analysis (molecular docking and molecular dynamics simulation studies) was performed. Sciadopitysin was identified as a potent molecule among all phytochemicals as it interacted with Caspase 3 with a binding energy of −7.2 kcal/mol. MD simulation studies also revealed that Sciadopitysin was stable inside the binding pocket of Caspase 3 by interacting with the amino acids in the catalytic site thereby activating the Caspase 3 levels. By all the above results, Shivagutika could be used as a potent anti-breast cancer agent (specifically DCM extract of Shivagutika) which could decrease the cases of breast cancer in future.
Sub-micron microparticles with tunable fluorescence emission obtained via co-self-assembly of amidoximed polymeric ligands and lanthanide ions
Authors: Qiu Huandi , Ran Qimeng , Bai Yun , He Wei , Zheng Li , Pan Cong , Jia Kun , Hu Yiguo
Published: May 2023

Lanthanide coordinating polymeric microparticles have witnessed increasing research interests during the past decades due to their versatile morphology and tunable fluorescent properties. Herein, we have synthesized an amidoximed block copolymer containing aromatic backbone and pendent amidoxime as well as carboxyl groups, which has been employed as the ligand to sensitize the intrinsic fluorescence emission of lanthanide ions of Tb3+ and Eu3+. Furthermore, the lanthanide coordinating polymeric microparticles showing tunable green and red emission fluorescence have been prepared via the emulsion confinement co-self-assembly of amidoximed polymeric ligands with Tb3+ and Eu3+. It is found that both the fluorescence emission and sizes of obtained fluorescent microparticles can be easily modulated in a wide range by tuning concentration of polymers and lanthanide ions, as well as emulsion evaporation temperature. Thanks to their tunable sizes (250–900 nm), fluorescence emission as well as presence of surface active functional groups, the present fluorescent microparticles would find potential applications in in-vitro detection, optical encoding and devices.
Amphotericin B colloidal dispersion: an effective drug for the treatment of mucormycosis in China
Authors: Liu Juntao , Ma Xiaoxu
Published: May 2023

Objective

Mucormycosis has emerged as an increasingly important cause of morbidity and mortality in immunocompromised patients, but the effective drugs for the treatment are limited. Hence, the study aimed to summarize the characteristics of mucormycosis in patients with hematological malignancies, and investigate the efficacy and safety of Amphotericin B Colloidal Dispersion (ABCD) in treating mucormycosis.

Methods

In this study, patients with mucormycosis complicated by hematological malignancies who received ABCD at the First Affiliated Hospital of Zhengzhou University from April 2021 to May 2022 were retrospectively enrolled. The clinical data of the enrolled patients were collected, and then, the drug response at 2 weeks, 4 weeks, and the end of treatment; the survival rate at 4, 8, and 12 weeks; and the laboratory-related indicators and adverse events (AEs) associated with ABCD were evaluated.

Results

In total, 9 patients with mucormycosis complicated by hematological malignancies were enrolled. The main symptoms were fever, cough, and chest pain. In addition, reversed halo signs (RHS) were found on chest CTs. The responses to ABCD at 2 weeks, 4 weeks, and the end of treatment were 100% (9/9), 77.8% (7/9), and 77.8% (7/9), respectively. The survival rates of the patients at 4, 8, and 12 weeks were 77.8% (7/9), 66.7% (6/9), and 66.7% (6/9), respectively. Among laboratory-related indicators, white blood cell (WBC) counts were significantly increased from baseline after 1 and 2 weeks of ABCD treatment (P<0.05), whereas neutrophil counts were only increased significantly from baseline at 2 weeks post-treatment (P<0.05). The most common AEs were infusion-related AEs manifesting as fever, chills, and pruritus. Moreover, none of the patients suffered from renal injury once again.

Conclusion

ABCD is a promising treatment strategy for patients with mucormycosis complicated by hematologic malignancies, showing remarkable efficacy and safety.