bluuebunny/crossref_metadata_2025 huggingface dataset:
Whole-Genome Sequencing, Phenotypic Characterization, and Antifungal Susceptibility Profiles of Three Aspergillus hortae Clinical Isolates from Colombia
Authors: Marín-Carvajal Santiago , Quiceno-Torres Mariana , Zuleta Maria Camila , Torres Susana , Rúa Álvaro Leon , García Ana Maria , Borges Clayton Luiz , López Angela Maria , McEwen Juan Guillermo , Ruiz Orville Hernandez , Gómez Oscar Mauricio
Published: September 2024

The Aspergillus genus comprises fungi that are widely distributed in nature. The Terrei section is particularly important due to its functions in recycling organic matter. Aspergillus hortae is a species from this section that has been isolated from clinical samples, but its role as a pathogenic agent is unclear. In this study, three clinical A. hortae isolates from Colombia, initially identified as A. terreus, were characterised by micro and macro-morphological analysis at 26°C and 37°C. A bioinformatic pipeline was used for molecular typing, which included analysis of whole genome sequences for accurate species identification. Susceptibility assays were also conducted using the microdilution broth method (EUCAST). It was confirmed that this species is intrinsically resistant to Amphotericin B with a minimum inhibitory concentration (MIC) of 2-4 mg/L, and is also thermotolerant. We obtained the in vitro susceptibility profiles for three azole drugs (MIC, 0.25-1 mg/L). The three isolates showed phylogenetic divergence from the reference genome strain. A mutation (M769K) in the MelA ortholog of a hypopigmented isolate, which had the lowest MIC value for AmB (2 mg/L), was identified. This study presents the morphological characterization, molecular typing through whole-genome analysis and identification of susceptibility profiles to azoles and amphotericin B of three clinical isolates of A. hortae from Colombia.
Microplastics and Their Impact on Human Health
Authors: Preda Olivia-Teodora , Vlasceanu Ana-Maria , Andreescu Cristina Veronica , Tsatsakis Aristides , Mezhuev Yaroslav , Negrei Carolina , Baconi Daniela Luiza
Published: September 2024

Increasing awareness of the potential health risks associated with microplastics (MPs) presence in the environment has led to significant rise in research focused on these particles over the past few years. This review focuses on research on MPs presence and spread, pathways of exposure and toxicological effects on human health and legal framework related to MP challenges. Several research projects have aimed to assess their potential harm to human health. Toxicological effects have been noticed at high concentrations of MPs, specifically polystyrene, the most widespread typical MP, but only short-term effects have been mostly studied. Significant quantities of consumed MP have been discovered to have diverse detrimental effects, posing a threat to human welfare. The exact concentrations of microplastics that are inhaled and swallowed and then build up in the human body are still not known. Further investigation is necessary to evaluate the impact of MP contamination at minimal concentrations and for prolonged durations.
Antibiotic Resistance Genes Detection in Several Local Cyanobacteria Isolates
Authors: Buniya Harith K. , Mohammed Nuha , Al-Hayani Dhyauldeen Aftan
Published: September 2024

Antibiotic resistance of cyanobacteria has been a global threat to public health. The widespread presence of cyanobacteria in aquatic environments exposes them to antibiotic contamination. The cyanobacteria are also in direct contact with pathogenic bacteria containing Antibiotic-Resistance Genes (ARGs) that gives them these characteristics. The study aims to the presence of some ARGs in locally isolated cyanobacteria species, Spirulina laxa, Chroococcus minutes, Oscillatoria princeps, Oscillatoria proteus, Oscillatoria terebriformis, Lyngbya epiphytica, and to compare the presence of these genes in two pathogenic bacteria, Escherichia coli and Klebsiella pneumoniae. The results revealed the presence of The ampicillin (Ap) and erythromycin (Em) resistance genes were detected in five algal samples. Meanwhile, the chloramphenicol (Cm) and gentamicin (Gm) resistance genes were apparent in only two species. Genes encoding resistance towards kanamycin (Km) and spectinomycin (Sp) were recorded in three specimens. The results also documented that E. coli possessed the resistance genes for four antibiotics: Ampicillin (Ap), Erythromycin (Em), Gentamicin (Gm), and Kanamycin (Km), whereas K. pneumoniae was resistant towards three anti-biotics: Ampicillin (Ap), Gentamicin (Gm), and Kanamycin (Km). The results show that there are a match in antibiotic resistance genes in both cyanobacteria and pathogenic bacteria. suggesting the possibility that cyanobacteria could acquire ARGs from the environment through horizontal gene transfer. Thus, freshwater cyanobacteria may play an important role in the prevalence of ARGs in their environment.
Internet of Things and Distributed Computer Systems in Business Models
Authors: Rosário Albérico Travassos , Raimundo Ricardo
Published: September 2024

The integration of the Internet of Things (IoT) and Distributed Computer Systems (DCS) is transforming business models across industries. IoT devices enable real-time monitoring of equipment and processes, reducing downtime and enhancing efficiency. In the case, manufacturing companies use IoT sensors to monitor machinery, predict failures, and schedule maintenance. Also, automation via IoT, reduces manual intervention, resulting in boosted productivity in smart factories and automated supply chains. IoT devices generate thus vast amounts of data, which businesses analyze to gain insights into customer behavior, operational inefficiencies, and market trends. In turn, distributed computer systems process this data, providing actionable insights and enabling advanced analytics and machine learning for future trend predictions. While, IoT facilitates personalized products and services by collecting data on customer preferences and usage patterns, enhancing satisfaction and loyalty, IoT devices support new customer interactions, like wearable health devices, and enable subscription-based and pay-per-use models in transportation and utilities. Conversely, real-time monitoring enhances security, as distributed systems quickly respond to threats, ensuring operational safety. It also aids regulatory compliance by providing accurate operational data. In this way, this study, through a Bibliometric Literature Review (LRSB) of 91 screened pieces of literature, aims at ascertaining to what extent the aforementioned capacities enhance business models. The study concludes that those systems leverage businesses, promoting competitive edge, continuous innovation, and adaptability to market dynamics. A review of 91 academic documents from the Scopus database highlights these impacts.
Synthesis, Herbicidal Activity, and Molecular Mode of Action Evaluation of Novel Quinazolinone−Phenoxypropionate Hybrids Containing a Diester Moiety
Authors: Wang Shumin , Li Na , Han Shibo , Fu Shuyue , Chen Ke , Ji Lusha , Cheng Wenjing , Lei Kang
Published: September 2024

To develop aryloxyphenoxypropionate herbicides with novel structure and improved activity, a total of twenty-eight novel quinazolinone–phenoxypropionate derivatives containing a diester moiety were synthesized and tested for herbicidal activity. The bioassay results in the greenhouse showed that QPEP-I-4 exhibited excellent herbicidal activity against E. crusgalli, D. sanguinalis, S. alterniflora, E. indica, and P. alopecuroides with inhibition rates >80% at a dosage of 150 g ha-1, and displayed higher crop safety to G. hirsutum, G. max, and A. hypogaea than the commercial herbicide quizalofop-p-ethyl. Studying of the molecular mode of action by phenotypic observation, membrane permeability evaluation, and transcriptomic analysis revealed that a growth inhibition of plant by QPPE-I-4 was the result from damage of plants biomembrane. The evaluation of ACCase activity in vivo indicated that QPPE-I-4 could inhibit ACCase and may be a new type of ACCase inhibitor. The present work demonstrated that QPPE-I-4 could serve as a lead compound for further developing novel AOPP herbicides.
B-Cell Maturation Antigen (BCMA) as a Biomarker and Potential Treatment Target in Systemic Lupus Erythematosus
Authors: Martin Jonas , Cheng Qingyu , Laurent Sarah A. , Thaler Franziska , Beenken Anne Elisabeth , Meinl Edgar , Krönke Gerhard , Hiepe Falk , Alexander Tobias
Published: September 2024

The BAFF-APRIL system is crucial for the pathogenesis of systemic lupus erythematosus (SLE) by promoting B cell survival, differentiation and the maintenance of humoral autoimmunity. Here, we investigated the relationship of BCMA expression on B cell subsets with its ligands BAFF and APRIL, together with soluble BCMA, and with clinical and serologic variables in a cohort of 100 SLE patients (86 under conventional and 14 under belimumab therapy) and 30 healthy controls (HC) using multicolor flow cytometry and ELISA. We found that BCMA expression in SLE patients was significantly increased on all B cell subsets compared to HCs, with all examined components of the BAFF-APRIL system being upregulated. BCMA expression was significantly increased on switched and unswitched memory B cells compared to naïve B cells, both in HCs and SLE. BCMA expression on B cells correlated with plasmablast frequencies, serum anti-dsDNA antibodies and complement consumption, while soluble BCMA correlated with plasmablast frequency, highlighting its potential as clinical biomarker. Belimumab treatment significantly reduced BCMA expression on most B cell subsets and soluble TACI, and contributes to the inhibition of almost the entire BAFF-APRIL system and restoration of B cell homeostasis. These results provide insights into the complex dysregulation of the BAFF-APRIL system in SLE and highlight the therapeutic potential of targeting its components, particularly BCMA, in addition to its use as biomarker for disease activity.
Do Fintechs Align More with Banks or Tech Firms?
Authors: Moro Visconti Roberto
Published: September 2024

This study investigates the strategic unity of fintech enterprises, assessing whether their characteristics bear greater resemblance to conventional banking institutions or technological corporations. Through the evaluation of operational functions, target demographics, business frameworks, stakeholder engagements, equity market dynamics, and empirical data, the analysis indicates that fintechs exhibit a closer alignment with technology companies. The inquiry uncovers significant lacunae in the prevailing scholarly discourse, particularly regarding the examination of fintechs’ fundamental attributes and their ramifications for strategic positioning. The results not only imply that fintechs are more akin to technology firms but also underscore the increasing convergence between fintechs and tech enterprises, propelled by the incursion of Big Tech and a heightened focus on sustainability. This implies an evolving financial landscape where traditional categorizations are progressively obscured. This research is pivotal for comprehending and navigating this emergent terrain, which holds paramount importance for professionals operating within the financial and technological domains.
Enhancing Romanian Naval Resilience to Climate Change: Advanced Functional Materials for Green Defence Strategies
Authors: Mihailov Maria Emanuela , Chirosca Alecsandru Vladimir , Chirosca Gianina , Ichim Miruna Georgiana
Published: September 2024

Climate change poses a significant threat to European security, implicitly to Romania’s naval forces in the Black Sea. Rising sea levels, extreme weather events, and ocean acidification impact maritime operations, infrastructure, and personnel, with potential ramifications for regional stability. This paper explores the implications of climate change for the Romanian Navy and proposes "Green Defence" strategies to enhance resilience and sustainability. These strategies encompass energy efficiency, renewable energy integration, sustainable procurement, and the application of advanced functional materials in naval operations and infrastructure. By adopting a proactive and multifaceted approach, the Romanian Navy can adapt to the changing climate, ensuring operational effectiveness while minimizing environmental impact. This approach aligns with broader European security concerns and contributes to a more sustainable and resilient defence posture in the face of climate-related challenges.
Effects of Biodegradation of Biobased Mulch Films Reinforced with Cellulose from Waste Mango
Authors: Lorenzo-Santiago Miguel Angel , Rendón-Villalobos Rodolfo , Contreras-Ramos Silvia Maribel , Pacheco-Vargas Glenda , García-Hernández Edgar
Published: September 2024

Excessive use of plastic mulches, has triggered a series of environmental problems, this is due to the large volumes generated and their low or non-existent degradability. For this reason, materials with similar characteristics to synthetic mulches are sought, but with a biodegradable character. In this work, mulches films were produced from gelatin (GC) and chitosan (ChC), reinforced with mango cellulose. Its biodegradation time in soil and a photographic analysis with scanning electron microscopy (SEM) were determined. GC sample presented a biodegradability of 97% at 30 days, and ChC lost 95% of its weight after 70 days exposed to soil. The SEM results for both mulch films presented some color changes after 30 days, completely fractured, the growth of mycelium on the surface and the presence of pores are observed. Obtaining polymers from waste materials, such as mango, represents an important task to obtain cellulose that can be used both to reinforce and to provide biodegradable character to biobased materials which can be degraded by microorganisms present in the soil. FTIR spectra revealed a decrease in hydroxyl groups, amides and carbonyls bands as the days of degradation increased.
Aqueous Extracts of Rhus trilobata Inhibit the LPS-Induced Inflammatory Response In Vitro and In Vivo
Authors: Rodríguez-Castillo Alejandra Jazmín , González-Chávez Susana Aideé , Portillo-Pantoja Ismael , Cruz-Hermosillo Eunice , Pacheco-Tena César , Chávez-Flores David , Delgado-Gardea Maria Carmen Elizabeth , Infante-Ramírez Rocío , Sánchez-Ramírez Blanca Estela
Published: September 2024

Chronic noncommunicable diseases (NCDs) are responsible for approximately 74% of deaths globally. Medicinal plants have traditionally been used to treat NCDs, including diabetes, cancer, and rheumatic diseases, and are a source of anti-inflammatory compounds. This study aimed to evaluate the anti-inflammatory effects of Rhus trilobata (Rt) extracts and fractions in lipopolysaccharide (LPS)-induced inflammation models in vitro and in vivo. The aqueous extract (RtAE) and five fractions (F2 to F6) were obtained via C18 solid-phase separation and tested in murine LPS-induced J774.1 macrophages. Key inflammatory markers such as IL-1β, IL-6, TNF-α, and COX-2 gene expression were measured using RT-qPCR, and PGE2 production was assessed via HPLC-DAD. The in vivo effects were tested in an LPS-induced paw edema model in Wistar rats. Results showed that RtAE at 15 μg/mL significantly decreased IL-1β and IL-6 gene expression in vitro. Fraction F6 further reduced IL-1β, TNF-α, and IL-6 gene expression, COX-2 expression, and PGE2 production. In vivo, F6 significantly reduced LPS-induced paw edema, inflammatory infiltration, and IL-1β and COX-2 protein expression. These findings support the anti-inflammatory potential of RtAE and F6, reinforcing the medicinal use of Rt.
Multi-timescale Energy Consumption Management in Smart Buildings Using Hybrid Deep Artificial Neural Networks
Authors: Ibude Favour Edose , Otebolaku Abayomi , Ameh Jude , Ikpehai Augustine
Published: September 2024

Energy consumption is a critical issue in the energy sector, and recent events such as the global energy crisis, costs, the need to reduce greenhouse emissions, and extreme weather conditions have increased the demand for energy efficiency. Accurately predicting energy consumption is one of the key steps to addressing inefficiency in energy consumption, and its optimization. In this regard, accurate predictions of energy consumption would not only help to minimize wastage, but also to save cost. In this article, we propose intelligent models using an ensemble of Convolutional Neural Network (CNN) and Long Short-Term Memory (LSTM) neural networks for predicting energy consumption in smart buildings. The proposed model outperforms other state-of-the-art deep learning models for predicting minute energy consumption, with a mean square error of 0.109. The proposed model also accurately captures latent trends in the data that other models struggle to capture. The results highlight the potential of using hybrid deep learning models for improved energy efficiency management in smart buildings.
Public Food Trees’ Usage and Perception, and Their Potential for Participatory Edible Cities: A Case-Study in Birjand, Iran
Authors: Colinas Juliette , Ugolini Francesca , Khalilnezhad Mohammad Reza
Published: September 2024

Public food trees are increasingly popular among researchers, urban planners and citizens, for their diversity of social, provisional and environmental benefits. However, the practice still faces several barriers, including the limited share of the population who uses them, and long-term management, studies to date suggesting municipality-citizen co-management partnerships as the most effective form, but still rare. Though participatory projects usually involve new plantations, several green spaces already harbor food trees which could be used to rapidly develop and test approaches for improving public usage and for co-management. Here we used a qualitative approach to explore usage and perception of public fruit trees and attitude towards public usage and participation, among green space visitors, staff and administrators of two urban green spaces harboring fruit trees in Birjand, Iran: one public park (Tohid Park) and one historic garden (Akbarieh Garden). Semi-structured interviews were conducted with twelve visitors of both spaces, four administrators and eight workers. We found that despite their great personal experience and interest in picking fruit, as well as a culture of strong relationships with fruit trees, visitors’ usage of the fruit was low, with a social norm against harvesting the fruit of others appearing as a main but easily remediable reason. Nevertheless, most visitors had a deep level of appreciation of these public fruit trees due in particular to the diverse pleasures that they provided (sensory, emotional, cognitive, experiential, social), and were greatly emotionally attached to them. They also had great interest in participating in their management and care, and more so in Tohid Park due to a greater potential social impact. According to some participants, education is needed to reduce damage that some citizens cause while picking fruit, or access should be restricted if maximizing production is the goal. These findings expand our understanding of the ways in which people can relate to existing urban fruit trees and suggest that they could be used to develop effective co-management schemes, thereby contributing to building smart and participatory edible cities.
The influence of the dynamics of the cost of drugs for the treatment of patients with malignant neoplasms on the costs of drug treatment in the Russian Federation.
Authors:   Federal Scientific State Budgetary Institution «N. A. Semashko National Research Institute of Public Health», Linnik S. A. ,   Non-government organization «Scientific society “Medical practice”, Tumenko E. E. ,   Federal Scientific State Budgetary Institution «N. A. Semashko National Research Institute of Public Health»,   Non-government organization «Scientific society “Medical practice”
Published: September 2024

Every year in the Russian Federation hundreds of billions of rubles are spent on the purchase of drugs for the treatment of patients with cancer, but the influence of the dynamics of the cost of drugs on the amount of money spent on their purchase has not been studied in our country. This was the purpose of this work. We studied the cost of drugs in 2019 and 2022. We compared the amounts of funds spent on their purchases in the Russian Federation and in the federal districts.
Bridging Theory and Practice in Arabic Language Education
Authors: Hidayatullah Ach Syarif , Fauji Imam
Published: September 2024

This study examines the alignment of the textbook "Al-Iktisyaf" with the inductive method in Arabic language education, focusing on nahwu learning. Through qualitative analysis, including literature review and descriptive study methods, the research identifies strengths and weaknesses in the textbook's approach. While "Al-Iktisyaf" follows the sequence of the inductive method, it lacks emphasis on practical nahwu learning, particularly Wadhifah Nahwiyyah. The findings highlight the need for supplementary resources to enhance practical exercises and contemporary linguistic approaches in Arabic language education.
Highlight:

Method analysis: "Al-Iktisyaf" and inductive approach in Arabic language education.
Practical learning: Strengths and weaknesses in functional nahwu instruction.
Supplementary resources: Essential for enhancing practical exercises in Arabic language education.

Keywoard: Arabic Language Education, Al-Iktisyaf Textbook, Inductive Method, Nahwu Learning, Supplementary Resources
Enhancing Class 6 Computer Education with Flash-Based Multimedia at Bukit Islamiah
Authors: Hajidorloh Aneefah , Untari Rahmania Sri
Published: September 2024

This research focuses on developing practical and efficient media for computer systems material aimed at grade 6 students. Employing the ADDIE model, the study progresses through analysis, design, development, and implementation stages to craft a flash-based interactive multimedia. A small-scale trial involving 5 students indicates promising results, with validation scores from media and material experts at 87% and 78%, respectively. Moreover, the average student response stands at 87.2%, affirming the suitability of the developed multimedia for learning purposes. This research underscores the potential of interactive multimedia in enhancing educational experiences, particularly in computer science education for young learners.
Highlights :

Implementation of ADDIE model ensures systematic development.
Flash-based multimedia yields high validation scores from experts.
Student response supports suitability for educational use.

Keywords: Interactive multimedia, Grade 6 education, Computer systems, ADDIE model, Learning efficiency
Effective and Professional Management of Village Tourism Objects Through BUMDes
Authors: Darmawan Mochammad Ramli , Agustina Isna Fitria
Published: September 2024

This study aims to analyze and describe the role of Village Owned Enterprises (BUMDes) in managing tourism objects in Sidokepung Village. The research is a qualitative study that focuses on the role of female village heads in empowering women. Data was collected through observation, interviews, and documentation, and analyzed using the data reduction, data presentation, and data verification proposed by Miles and Huberman. The results indicate that the motivator dimension in tourism management was not successful, the facilitator dimension was not optimal, and the Dynamisator was not implemented properly. The implications of these findings suggest that there is a need for improvement in the management of tourism objects in Sidokepung Village, particularly in the areas of motivation, facilitation, and dynamization.
Highlight :

Limited success: BUMDes management of tourism in Sidokepung fell short in motivating, facilitating, and dynamizing the sector.
Female leadership focus: Research explored the specific role of female village heads in empowering women through tourism initiatives.
Areas for improvement: Findings highlight the need for enhanced strategies in motivation, facilitation, and dynamization to boost tourism success

Keywords: BUMDes, Sidokepung village, tourism, female leadership, women empowerment
KINARA BUMDes: Enhancing Management Strategies for Community Prosperity
Authors: Sahara Nyimas Ifada , Choiriyah Ilmi Usrotin
Published: September 2024

This study employs qualitative descriptive methods, utilizing observation, interviews, and documentation to investigate the management of Kinara BUMDes in Kemiri Village, Sidoarjo Regency, through the lens of management theory by George R. Terry. Despite facing challenges induced by the COVID-19 pandemic, the village government demonstrated resilience in planning, reinvigorating Kinara BUMDes through new management units. The organizational structure was efficiently organized, ensuring a well-defined division of labor and effective communication. Results indicate successful actuation in achieving organizational goals and meticulous supervision, promoting transparency at all levels of society. The study emphasizes the adaptability and strategic planning of rural economic units, offering insights for global scholars interested in sustainable rural development practices.
Highlight :

Strategic Planning: Despite the challenges posed by COVID-19, the study highlights the ability of Kinara BUMDes to adapt and revitalize through strategic planning, showcasing resilience in the face of unforeseen circumstances.

Organizational Efficiency: The research underscores the importance of well-organized structures within BUMDes, emphasizing a clear division of labor, effective communication, and efficient supervision as crucial elements for achieving organizational goals.

Transparency for Community Engagement: The findings reveal a commitment to transparency, ensuring that all activities conducted by Kinara BUMDes are accessible to and understood by all levels of society, fostering community engagement and support.

Keywords: Rural Economic Units, BUMDes Management, Sustainable Development, COVID-19 Resilience, Organizational Transparency
Transforming Population Administration for Global Smart Cities through Sipraja
Authors: Agustina Nuke Kenya , UB Ahmad Riyadh
Published: September 2024

This study analyzes the implementation of the SIPRAJA Application Program for population administration services in Bluru Kidul Village. Using a descriptive qualitative approach, data were collected through interviews, observation, and documentation, and analyzed using Miles and Huberman's model. The study, guided by Merille S. Grindle's framework, found that while SIPRAJA aligns with its objectives and provides timely service satisfaction, it faces challenges in socialization and technological readiness. Only 19% of residents use the program, preferring conventional services due to technological limitations and unavailable system features. The findings highlight the need for improved socialization and training to enhance resident participation and system effectiveness, contributing to smart city goals.
Highlights:

Program Success: SIPRAJA meets objectives, offers timely service satisfaction.
Challenges: Socialization and technological readiness limit resident participation.
Recommendations: Improve socialization and training for better system adoption.

Keywords: SIPRAJA, population administration, Bluru Kidul, qualitative research, public service
Improving the Quality of Public Services from an Indonesian Village Perspective
Authors: Utami Fitria Rochma , Mursyidah Lailul
Published: September 2024

This qualitative study examines the quality of population administration services in Bluru Kidul Village, Indonesia, aligning with the government's mandate to provide essential services as per Law Number 25 of 2009. Through interviews, observations, and document analysis, the research evaluates service quality dimensions including tangibles, reliability, responsiveness, assurance, and empathy. Findings indicate a favorable service environment, prompt and accurate service provision, swift handling of requests, caring employee attitudes, and friendly, non-discriminatory treatment of service users. These insights offer valuable guidance for policymakers and administrators to enhance service quality, thereby fostering greater citizen satisfaction and trust in government institutions.
Highlights:

Thorough assessment of population service quality.
Adherence to Indonesia's governmental mandate.
Priority on citizen satisfaction and trust.

Keywords: Population administration services, Service quality assessment, Government mandate, Indonesia, Citizen satisfaction.
Time Required for Education Up to College Level
Authors: Kusuma Kumara Adji
Published: September 2024

This study explores the imperative of mandatory college education in Indonesia, amidst recent protests against rising tuition fees. Despite higher education's recognized socio-economic benefits, Indonesia has yet to mandate college attendance, lagging behind global trends. Drawing on comparative analysis with Malaysia, South Korea, and European nations, the research underscores the potential of mandatory college education to enhance workforce skills, promote innovation, and reduce social disparities. Findings advocate for government commitment, increased funding, and collaboration with the private sector to ensure equitable access and quality in higher education, ultimately driving economic growth and social development.
Highlights :
 

Global Trends Comparison: Benchmarks Indonesia against leading nations for educational policy insight.
Equitable Access and Quality: Ensuring fairness and standards for a skilled, diverse workforce.
Government-Private Sector Collaboration: Partnerships vital for sustainable funding and educational enhancement.

Keywords: Mandatory Education, Indonesia, Socio-Economic Benefits, Collaboration, Funding
Main Directions of Modernization of Services in Uzbekistan
Authors: Sattarov Sattarov
Published: September 2024

The essence of the notion of modernization and the specifics of service sector modernization are described in this article. The essential directions for Uzbekistan's service sector modernization are also proposed
Komunikasi Dialogis dalam Rangka Penyelesaian Konflik antara Pelaku Industri Dengan Masyarakat
Authors: Sabiati  , Hastjarjo Sri , Sudarmo
Published: September 2024

Multi-group conflict occurs when community groups with different interests from other groups have a variety of priorities for each resource and the development of management policies. Likewise in the dynamics of conflict between industry players and the community in defending their every interest. Conflict complexity basically includes various combinations of power, value and economic resources. Related to complexity which is often beyond the authority of institutions in general and there are standard procedures that have been carried out so far, to build consensus from various stakeholders, it is necessary to have a resolution by conducting a collaborative approach involving various other constituents. This collaborative approach in groups needs to be carried out dialogically in order to get an understanding between the conflicting groups. Then, among others, they reach consensus to achieve the desired resolution between the interests of stakeholders.
Mare’s Milk Productivity of Different Breeds
Authors: Kalimbetov Bakhadir Salauat ugli
Published: September 2024

In the Republic of Uzbekistan, camel and horse breeding are mainly practiced in the northern Kyzylkum regions of the Republic of Karakalpakstan. In the Republic of Karakalpakstan, the total number of annuals in all kinds of farms is currently 7070. Improving horse productivity and making full use of their genetic potential, creating productive lines, and developing effective strategies to promote output are all crucial.
The "mass of people" in the postmodern perspective according to Jose Ortega-i-Gasset's "Mass Rebellion"
Authors: Chaghalidze Eka
Published: September 2024

The article "Mass Revolt in the Postmodern Perspective by Jose Ortega-i-Gasset" deals with Jose Ortega-i Gasset and Martin Heidegger's definition of the specifics of mass society. Their views on "mass society", "mass man" and "man - mass". The main focus is on the nature of mass society in the post-righteous era, as well as on the new features of the postmodern era of the "human mass". The concluding section summarizes and outlines the role of mass culture in the postmodern era, how the relationship between man-mass and the intellectual in the postmodern era can be imagined.
Characteristics of the School Education System in England
Authors: Shozoda Muftillayeva
Published: September 2024

Today, the United Kingdom is one of the leaders in the quality and level of education. There are several reasons for this level of education. To understand these reasons, we must first look at the history of education in England. Education in England in the Middle Ages was very different from what it is today. only church members were engaged.
Economic Reforms of the Soviet State in the Years of Reconstruction
Authors: Eshmamatov Alizod
Published: September 2024

In the mid-1980s, the Soviet state implemented a program of reforms that went down in history as "reconstruction." The history of this program is connected with the personality of Mikhail Gorbachev, who was elected Secretary-General of the Central Committee of the CPSU in March 1985. The election of Mikhail Gorbachev, a young member of the highest political leadership at the time, was a sign that the party apparatus was trying to change the declining totalitarian regime a bit. The beginning of radical reforms in public administration, and broad socio-political and economic changes was connected with the decisions of the April plenum of the Central Committee of the CPSU. The leadership sought to develop the state through reforms, taking into account the current crisis in all spheres of the USSR.
The Role of Phonetics in Pronunciation English Borrowing in Medical Terminology
Authors: Khamdamova Shakhnoza Yusupalievna
Published: September 2024

The purpose of the study is to study the process of borrowing medical terminology, expressions used in the daily speech of a physician, the causes and methods of the emergence of foreign words. The relevance of this study lies in the need to understand the exact meaning of frequently used words and expressions of medical vocabulary, as well as the exact knowledge of their etymology.
The acute effects of non-concussive head impacts in sport: A randomised control trial.
Authors: Delang Nathan , Robertson Rebecca V. , Mendoza Fernando A. Tinoco , Henderson Luke A. , Rae Caroline , McDonald Stuart J. , Desbrow Ben , Irwin Christopher , Peek Aimie L. , Cairns Elizabeth A. , Austin Paul J. , Green Michael A. , Jenneke Nicholas W. , Cao Jun , O’Brien William T. , Ball Shane , Buckland Michael E. , Rae Katherine , McGregor Iain S. , McCartney Danielle
Published: September 2024

Background
Head impacts, particularly, non-concussive impacts, are common in sport. Yet, their effects on the brain are poorly understood. Here, we investigated the acute effects of non-concussive impacts on brain microstructure, chemistry, and function using magnetic resonance imaging (MRI) and other techniques.
Results
Fifteen healthy male soccer players completed this randomised, controlled, crossover trial. Participants completed a soccer heading task (‘Heading’; the Intervention) and an equivalent ‘Kicking’ task (the Control); followed by a series of MRI sequences between ~ 60–120 minutes post-tasks. Blood was also sampled, and cognitive function assessed, pre-, post-, 2.5 hours post-, and 24 hours post-tasks. Brain chemistry: Heading increased total N-acetylaspartate (p = 0.012) and total creatine (p = 0.010) levels in the primary motor cortex (but not the dorsolateral prefrontal cortex) as assessed via proton magnetic resonance spectroscopy. Glutamate-glutamine, myoinositol, and total choline levels were not altered in either region. Brain structure: Heading had no effect on diffusion weighted imaging metrics. However, two blood biomarkers expressed in brain microstructures, glial fibrillary acidic protein and neurofilament light, were elevated 24 hours (p = 0.014) and ~ 7-days (p = 0.046) post-Heading (vs. Kicking), respectively. Brain function: Heading decreased tissue conductivity in five brain regions (p’s < 0.001) as assessed via electrical properties tomography. However, no differences were identified in: (1) connectivity within major brain networks as assessed via resting-state functional MRI; (2) cerebral blood flow as assessed via pseudo continuous arterial spin labelling; (3) electroencephalography frequencies; or (4) cognitive (memory) function.
Conclusions
This study identified chemical, microstructural and functional brain alterations in response to an acute non-concussive soccer heading task. These alterations appear to be subtle, with some only detected in specific regions, and no corresponding functional deficits (e.g., cognitive, adverse symptoms) observed. Nevertheless, our findings emphasise the importance of exercising caution when performing repeated non-concussive head impacts in sport.
Trial registration
ACTRN12621001355864. Date of registration 7/10/2021. URL https//www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=382590&isReview=true
Evaluation of bio-efficacy of Metarhizium anisopliae against the pink bollworm Pectinophora gossypiella (Saunders), with insights into its colonization potential and insecticide compatibility
Authors: Snehal THAVKAR , Thube Shivaji Hausrao , Pramod PANCHBHAI , Nandkishor LAVHE , Tinni PILLAI , Vivek SHAH , Vrushali DESHMUKH , Thavaprakasa PANDIAN R. , Babasaheb FAND , Prabhulinga TENGURI , Akash NIKOSHE , Priyank MHATRE , Gajanan BEHERE , Yenumula PRASAD
Published: September 2024

Background
The pink bollworm (Pectinophora gossypiella) is a major pest of cotton, causing economic losses by damaging seeds and fiber. Cotton growers typically use systemic and broad-spectrum insecticides for its management, which pose risks to human health and the environment. Consequently, there is a need for eco-friendly alternatives. This study evaluates the bio-efficacy of the entomopathogenic fungus Metarhizium anisopliae strain TMBMA1 against pink bollworm and assesses its compatibility with major insecticides. Additionally, to comprehend the dynamics of colonization and the infection processes of EPF, scanning electron microscopy (SEM) of infected larvae was carried out.
Result
We challenged second instar PBW larvae to eight different concentrations (1×10³ to 1×10¹⁰ conidia ml-1) of M. anisopliae TMBMA1. The highest mortality (100%) occurred at the highest concentrations i.e., 1×10⁹ and 1×10¹ spores ml-1, while the lowest mortality rate (46.6%) was observed at 1×10³ spores ml-1 concentration compared to control (3.33%). TMBMA1's biocontrol efficacy was validated by Probit analysis, exhibiting an exceptionally low LC50 value of 7.1 × 10⁵. The comparative evaluation revealed that M. anisopliae TMBMA1 performed par excellent with insecticide (Cypermethrin 20EC) giving 100% mortality, both being superior to a commercial product of M. anisopliae (60%). The EPF strain was profusely colonized on both the internal and external surfaces of PBW larvae, according to SEM analysis. Compatibility studies with insecticides revealed > 98% and > 96% reduction in the sporulation of M. anisopliae due to the treatment of Emamectin Benzoate 1.5% + Profenofos 35% WDG and Profenofos 50EC, respectively. In contrast, Cypermethrin 10% EC, Emamectin Benzoate 5% SG and Neem Seed Kernel Extract (NSKE 1500 PPM) treatments reported minimal reduction (11%, 13% and 21% respectively) in spore production.
Conclusion
According to the current investigations, the M. anisopliae strain TMBMA1 exhibits high virulence against PBW and offers a promising eco-friendly solution for managing this pest. It shows significant potential to proliferate on both external and internal surfaces of PBW. This strain can be integrated into PBW management programs with chemical insecticides, thereby improving pest control and lessen environmental impact.
Combined surgery with intramedullary rod fixation across the ankle for the treatment of Crawford IV congenital pseudarthrosis of the tibia: a long-term follow-up study
Authors: liu xiping , liu kun , Zhu Guanghui
Published: September 2024

Background: The combined surgery with tibial intramedullary(IM) rod fixation across the ankle for the treatment of Crawford IV congenital pseudarthrosis of the tibia (CPT) is the most classic and effective surgical treatment method. The aim of this study is to explore the long-term clinical efficacy of combined surgery for the treatment of Crawford IV congenital pseudarthrosis of the tibia(CPT).
Methods：A retrospective analysis was conducted on 82 cases of Crawford IV CPT who underwent combined surgical treatment with tibial intramedullary(IM) rod fixation through the ankle, to evaluate their long-term clinical efficacy and postoperative complications.
Results：The average surgical age of the patient was (43.17 ± 13.40) months (range: 18-96 months), with an initial bone healing rate of 100%, and an average postoperative follow-up time of (119.78 ± 20.08) months (range: 84-146 months); At the last follow-up, there were a total of 20 cases of re fractures, including 15 cases in the complete insertion of IM rods into the tibial medullary cavity group, 2 cases in the tibial IM rod across the ankle fixation group, and 3 cases in the tibial IM rod removal group; There were a total of 28 cases of developmental bending and angular deformity of the tibial shaft after bone healing, including 26 cases in the complete insertion of IM rods into the tibial medullary cavity group, 0 cases in the tibial IM rod across the ankle fixation group, and 2 cases in the tibial IM rod removal group；All cases in the complete insertion of IM rods into the tibial medullary cavity group showed tibial IM rods deviating from the center of the medullary cavity, with a displacement rate of up to 100%.
Conclusions：The combined surgery of tibial IM rod fixation across the ankle for the treatment of Crawford IV CPT has a high initial bone healing rate and definite therapeutic effect, but there are still many postoperative complications. The fixation status of tibial IM rods is an important influencing factor for tibial shaft developmental angular bending deformity and re fractures after initial bone healing.
A redox-related lncRNA signature in bladder cancer
Authors: Zhao Fuguang , Xie Hui , Guan Yawei , Teng Jingfei , Li Zhihui , Gao Feng , Luo Xiao , Ma Chong , Ai Xing
Published: September 2024

Redox status is closely associated with the development and progression of cancer, which can be modulated by long non-coding RNA (lncRNA). A series of previous studies have demonstrated that redox regulation can be treated as a potential treatment option for cancer. However, the redox-related lncRNA predictive signature of bladder cancer (BCa) still remains unknown. The purpose of our study is to construct a redox-related lncRNA signature for better prediction of BCa patients’ prognosis. We downloaded transcriptome and clinical data from the Cancer Genome Atlas (TCGA) database. The prognostic redox-related lncRNAs were identified by univariate Cox regression, least absolute shrinkage and selection operator (LASSO) regression, and multivariate Cox regression analysis and two risk groups were established. A comprehensive analysis corresponding to clinical features between high-risk and low-risk groups was conducted. Eight redox-lncRNAs (AC018653.3, AC090229.1, AL357033.4, AL662844.4, AP003352.1, LINC00649, LINC01138, MAFG-DT) were selected and constructed the risk model. The overall survival (OS) in high-risk group was worse than that in low-risk group (p < 0.001). The redox-related lncRNA signature has a better predictive accuracy than clinicopathological characteristics. GSEA analysis showed the MAPK signaling pathway and WNT signaling pathway were enriched in the high-risk group. Compared with the low-risk group, the patients in high-risk group were more sensitive to cisplatin, docetaxel, and paclitaxel. Furthermore, IGF2BP2, a potential target gene of MAFG-DT, was overexpressed in tumor tissues and was correlated with OS. Our study proved that the predictive signature constructed by eight redox-related lncRNAs can independently and accurately predict the prognosis of BCa patients.
Results of the suture bridge technique in the treatment of the posterior cruciate ligament tibial insertion avulsion fracture
Authors: Pu Jinsong , Zheng Lin , Jian Changchun
Published: September 2024

This study aimed to evaluate the operative techniques and clinical outcomes of a minimally invasive suture bridge technique for repairing posterior cruciate ligament (PCL) tibial avulsion fractures. A retrospective analysis of 18 patients treated between January 2018 and December 2022 was conducted. The patients, aged 21 to 48 years, underwent arthroscopic surgery with a small posteromedial arc incision. The suture bridge technique was employed for secure fixation, resulting in effective fracture healing and minimal impact on the bone bed. Follow-up, ranging from 12 to 18 months, showed significant improvements in Lysholm and IKDC scores postoperatively. The technique offers a safe and efficient method, particularly suitable for comminuted fractures, with no cases of anchor loosening, refracture, or displacement observed. The minimally invasive nature of the procedure and its adaptability to various fracture types highlight its potential as a promising treatment for PCL tibial avulsion fractures.
Age- and Sex-Specific Reference Percentile Curves for Accelerometry-Measured Physical Activity in Healthy European Children
Authors: Ploegstra Mark-Jan , Swenne Annika , Buck Christoph , Moreno Luis , Lissner Lauren , Lauria Fabio , de Henauw Stefaan , Molnar Dénes , Tornaritis Michael , Konstabel Kenn , Rayson Mark , Pitsiladis Yannis , Manios Yannis , Béghin Laurent , Widhalm Kurt , Polito Angela , Sinningen Kathrin , Kafatos Anthony , Martinez Sonia Gomez , Gonzalez-Gross Marcela , Casajús José Antonio , Mazur Artur , Ortega Francisco , Ahrens Wolfgang , Berger Rolf , Intemann Timm
Published: September 2024

PURPOSE:
Physical activity measured by accelerometry (PA-accelerometry) is used as an indicator of disease severity in chronic diseases. Currently, only fragmented age ranges of reference percentile curves are available for European children. This study aimed to provide age- and sex-specific percentiles for physical activity measured by hip-worn accelerometry derived throughout the full age range of European children.
METHODS:
Individual-level population-based PA data from HELENA and IDEFICS/I.Family studies were pooled and harmonized. Together these studies involved children aged 2–18 years from 12 European countries. PA was measured using uni-axial or tri-axial Actigraph accelerometers. Accelerometry recording was defined as valid if lasted at least 6 hours on at least 2 weekdays and 1 weekend day. Primary outcomes included averaged counts per minute (CPM), sedentary time (SED), light PA (LPA) and moderate-to-vigorous PA (MVPA). Generalized Additive Models for Location, Scale and Shape were used to derive age- and sex-specific reference percentile curves for these outcomes.
RESULTS:
The combined cohort consisted of 11,645 children aged 2 to 18 years who contributed 14,610 valid accelerometry recordings, with a median accelerometer wear time of 6 days and a median wear time of 745 minutes per day. This dataset allowed for the construction of age- and sex-specific reference percentile curves for CPM, SED, LPA, and MVPA. The curves demonstrated varying trends and variability across age groups.
CONCLUSIONS:
This study provides age- and sex-specific percentile curves for PA-accelerometry in European children, addressing a current gap in the availability of full-age range reference data. These curves based on healthy children can be used by clinicians, researchers, and policymakers to interpret PA-accelerometry measurements, assess severity of disease in paediatric chronic illness, track physical activity trends, and evaluate treatment responses and health interventions.