bluuebunny/crossref_metadata_2025 huggingface dataset:
The Association between Macular Thickness and Axial Length in Myopic Eyes
Authors: Chung Yeon Woong , Choi Moon Young , Kim Jung-sub , Kwon Jin-woo
Published: July 2019

Purpose. To investigate the relationship between macular thickness and axial length (AL) in myopic eyes. Methods. We included 441 myopic eyes in this study and measured macular thickness at the fovea and in other macular regions, using optical coherence tomography. We got thickness difference indices (TDIs) which by definition are the values of thickness difference obtained by subtracting the foveal thickness from that of each macula sector to evaluate macular contour. We then analyzed the relationships between AL and foveal thickness and AL and the TDIs of each macular sector. Results. In polynomial regression analyses, foveal thickness slope was relatively flat up to an AL of 25.5 mm and began to rise from 25.5–26.0 mm. The TDIs were also relatively flat up to AL of 25.5mm and started to show steepened negative slopes from around AL of 25.5 mm. When grouping myopia participants as high myopia or non-high myopia based on AL of 25.5mm, all macular indices of the high myopia group showed significant correlation with AL (all p values <0.01). But all indices of non-high myopia group had no significant correlation with AL. Conclusions. Average macular thickness profiles showed that appreciable changes started at an AL of 25.5mm.
Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells
Authors: Jackson Mark R. , Bavelaar Bas M. , Waghorn Philip A. , Gill Martin R. , El-Sagheer Afaf H. , Brown Tom , Tarsounas Madalena , Vallis Katherine A.
Published: July 2019

Telomerase is expressed in the majority (>85%) of tumors, but has restricted expression in normal tissues. Long-term telomerase inhibition in malignant cells results in progressive telomere shortening and reduction in cell proliferation. Here we report the synthesis and characterization of radiolabeled oligonucleotides that target the RNA subunit of telomerase, hTR, simultaneously inhibiting enzymatic activity and delivering radiation intracellularly. Oligonucleotides complementary (Match) and noncomplementary (Scramble or Mismatch) to hTR were conjugated to diethylenetriaminepentaacetic dianhydride (DTPA), allowing radiolabeling with the Auger electron-emitting radionuclide indium-111 (111In). Match oligonucleotides inhibited telomerase activity with high potency, which was not observed with Scramble or Mismatch oligonucleotides. DTPA-conjugation and 111In-labeling did not change telomerase inhibition. In telomerase-positive cancer cells, unlabeled Match oligonucleotides had no effect on survival, however, 111In-labeled Match oligonucleotides significantly reduced clonogenic survival and upregulated the DNA damage marker γH2AX. Minimal radiotoxicity and DNA damage was observed in telomerase-negative cells exposed to 111In-Match oligonucleotides. Match oligonucleotides localized in close proximity to nuclear Cajal bodies in telomerase-positive cells. In comparison with Match oligonucleotides, 111In-Scramble or 111In-Mismatch oligonucleotides demonstrated reduced retention and negligible impact on cell survival. This study indicates the therapeutic activity of radiolabeled oligonucleotides that specifically target hTR through potent telomerase inhibition and DNA damage induction in telomerase-expressing cancer cells and paves the way for the development of novel oligonucleotide radiotherapeutics targeting telomerase-positive cancers.

Significance:

These findings present a novel radiolabeled oligonucleotide for targeting telomerase-positive cancer cells that exhibits dual activity by simultaneously inhibiting telomerase and promoting radiation-induced genomic DNA damage.
HDAC6 Inhibition Synergizes with Anti-PD-L1 Therapy in ARID1A-Inactivated Ovarian Cancer
Authors: Fukumoto Takeshi , Fatkhutdinov Nail , Zundell Joseph A. , Tcyganov Evgenii N. , Nacarelli Timothy , Karakashev Sergey , Wu Shuai , Liu Qin , Gabrilovich Dmitry I. , Zhang Rugang
Published: July 2019

ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in more than 50% of ovarian clear cell carcinomas (OCCC), a disease that currently has no effective therapy. Inhibition of histone deacetylase 6 (HDAC6) suppresses the growth of ARID1A-mutated tumors and modulates tumor immune microenvironment. Here, we show that inhibition of HDAC6 synergizes with anti-PD-L1 immune checkpoint blockade in ARID1A-inactivated ovarian cancer. ARID1A directly repressed transcription of CD274, the gene encoding PD-L1. Reduced tumor burden and improved survival were observed in ARID1Aflox/flox/PIK3CAH1047R OCCC mice treated with the HDAC6 inhibitor ACY1215 and anti-PD-L1 immune checkpoint blockade as a result of activation and increased presence of IFNγ-positive CD8 T cells. We confirmed that the combined treatment limited tumor progression in a cytotoxic T-cell–dependent manner, as depletion of CD8+ T cells abrogated these antitumor effects. Together, these findings indicate that combined HDAC6 inhibition and immune checkpoint blockade represents a potential treatment strategy for ARID1A-mutated cancers.

Significance:

These findings offer a mechanistic rationale for combining epigenetic modulators and existing immunotherapeutic interventions against a disease that has been so far resistant to checkpoint blockade as a monotherapy.

See related commentary by Prokunina-Olsson, p. 5476
Deciphering the Role of Protein Kinase D1 (PKD1) in Cellular Proliferation
Authors: Youssef Ilige , Ricort Jean-Marc
Published: July 2019

Protein kinase D1 (PKD1) is a serine/threonine kinase that belongs to the calcium/calmodulin-dependent kinase family, and is involved in multiple mechanisms implicated in tumor progression such as cell motility, invasion, proliferation, protein transport, and apoptosis. While it is expressed in most tissues in the normal state, PKD1 expression may increase or decrease during tumorigenesis, and its role in proliferation is context-dependent and poorly understood. In this review, we present and discuss the current landscape of studies investigating the role of PKD1 in the proliferation of both cancerous and normal cells. Indeed, as a potential therapeutic target, deciphering whether PKD1 exerts a pro- or antiproliferative effect, and under what conditions, is of paramount importance.
Prevalence and Incidence of Mild Cognitive Impairment across Subtypes, Age, and Sex
Authors: Overton Marieclaire , Pihlsgård Mats , Elmståhl Sölve
Published: July 2019

Objective: The purpose of this study was to report on the prevalence and incidence of mild cognitive impairment (MCI) across age, sex, and subtypes according to various criteria in a population-based sample. Methods: The sample was drawn from the Swedish Good Aging in Skåne (GÅS) population study, and data from 3,752 participants aged 60 years and more were used to calculate the MCI prevalence. The incidence was calculated using 2,093 participants with 6-year follow-up data. MCI was defined according to the expanded Mayo Clinic criteria: cognitive complaint, objective cognitive impairment (two different criteria depending on the severity of impairment), preserved functional abilities, and no dementia. Results: The prevalence estimates ranged from 5.13 to 29.9% depending on age and severity of impairment. The incidence rates of overall MCI were 22.6 (95% confidence interval [CI]: 19.6–25.9) and 8.67 (95% CI: 7.0–10.7) per 1,000 person-years for less severe and severe cognitive impairment, respectively. The highest prevalence and incidence estimates were found for “non-amnestic MCI single domain.” The older age groups had a higher prevalence, and no sex or age differences in MCI incidence were detected. Conclusion: Our findings concur with previous research advocating that MCI is a heterogeneous concept, since the prevalence and incidence estimates differed substantially according to age, MCI subtype, and severity of cognitive impairment.
A Rare Presentation of Biclonal Gammopathy in Multiple Myeloma with Simultaneous Extramedullary Involvement: A Case Report
Authors: Kancharla Pragnan , Patel Eshan , Hennrick Kenneth , Ibrahim Sherif , Goldfinger Mendel
Published: July 2019

Multiple myeloma is characterized by an abnormal clone of plasma cell infiltration in the bone marrow and presence of a high level monoclonal immunoglobulin (M-protein) in the serum or urine in most cases. The monoclonal protein is usually detected as a discrete band in the gamma globulin region by serum protein electrophoresis. Rarely, it may show a simultaneous presence of two distinct bands, which could be either from a single clone, or two separate clones. We report a very unusual presentation of biclonality with lambda restricted IgG predominant cells from cervical lymph node and kappa restricted IgA cells from the bone marrow simultaneously.
Procalcitonin and N-Terminal Pro-B-Type Natriuretic Peptide for Prognosis in Septic Acute Kidney Injury Patients Receiving Renal Replacement Therapy
Authors: Sheng Xiaohua , Yang Jingye , Yu Gang , Fei Yang , Bao Hongda , Yin Jianyong , Huang Weifeng , Tian Zebo , Wang Niansong , Ronco Claudio
Published: July 2019

Background: Sepsis is a complex clinical syndrome leading to severe sepsis and septic shock. It is very common in the intensive care unit with high mortality. Thus, judging its prognosis is extremely important. Procalcitonin (PCT) and ­N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are commonly elevated in sepsis patients, but only a few are discussed in the septic acute kidney injury patients (AKI) who received renal replacement therapy (RRT). Our study is aimed at investigating the prognostic value of PCT and NT-proBNP in septic AKI patients who received RRT. Methods: This was a retrospective study of septic AKI patients who underwent RRT in a Chinese university hospital. All enrolled patients tested PCT and NT-proBNP at RRT initiation. PCT and NT-proBNP levels were compared between the survivors and non-survivors. Receiver operating characteristic (ROC) curves of the 2 biomarkers were performed for predicting in-hospital mortality. According to the median value of PCT (16.2 ng/mL) and NT-proBNP (10,271 pg/mL), patients were divided into 4 groups (low PCT and low NT-proBNP; high PCT and low NT-proBNP; low PCT and high NT-proBNP; high PCT and high NT-proBNP). The Kaplan-Meier survival curves were used to analyze the 28-day survival rate in the 4 groups. Results: A total of 81 patients were enrolled in the study. Of which, 48 (59.3%) patients died during hospitalization. The median of NT-proBNP in non-survivors was significantly higher than in survivors (p = 0.001), while PCT had no significant difference (p = 0.412). The area under the ROC curve of PCT and NT-proBNP for predicting in-hospital mortality was 0.561 (95% CI 0.426–0.695) and 0.729 (95% CI 0.604–0.854). Kaplan-Meier survival curve analysis showed that increased NT-proBNP level was associated with 28-day mortality while combined with PCT there was no statistical difference in 4 different level groups. Conclusion: NT-proBNP has a certain predictive value for the prognosis in septic AKI patients who received RRT. It seems that the initial PCT value for prognosis is limited. The combination of PCT and ­NT-proBNP to evaluate the prognosis in these critically ill patients is currently unclear.
Eccrine Porocarcinoma on the Lateral Nose Wall: A Rare Case Report
Authors: Fukui Kiyoko , Fujioka Masaki , Matsuo Haruka , Noguchi Miho
Published: July 2019

Eccrine porocarcinoma (EPC) is an uncommon malignant tumor derived from the eccrine sweat glands. We present a case of EPC on the lateral nose wall, in which the tumor was excised, and the resultant defect was reconstructed using a nasolabial flap. A 66-year-old female was referred to the Department of Plastic and Reconstructive Surgery to receive treatment for a cutaneous tumor on her right lateral nose wall, which had been growing rapidly for 3 months. Histological analysis of a biopsy specimen of the tumor suggested that it was a squamous cell carcinoma. Surgical excision was performed with a 3-mm margin. The tumor was histologically diagnosed as an EPC. EPC exhibits various pathological features; therefore, it is often confused with other malignant cutaneous tumors. We consider that histologically examining surgical specimens obtained via total resection, rather than incisional biopsy specimens, is important for correctly diagnosing EPC.
Risk of Ovarian Malignancy Algorithm versus Risk Malignancy Index-I for Preoperative Assessment of Adnexal Masses: A Systematic Review and Meta-Analysis
Authors: Chacón Enrique , Dasí Joana , Caballero Carolina , Alcázar Juan Luis
Published: July 2019

Purpose: To perform a systematic review and meta-analysis of studies comparing the diagnostic accuracy of Risk of Ovarian Malignancy Algorithm (ROMA) and risk of malignancy index (RMI) for detecting ovarian cancer. Methods: A systematic review and meta-analysis was performed according to PRISMA statement. A search for studies evaluating the diagnostic performance of ROMA and RMI-I indices for detecting ovarian malignancy from January 2010 to October 2018 was performed in the PubMed/MEDLINE and Web of Science databases. The quality of the studies was evaluated by the Quality Assessment of Diagnostic Accuracy Studies 2. Results: Sixty-six citations were identified. After exclusions, 8 papers comprising 2,662 women (1,319 premenopausal and 1,343 postmenopausal) were ultimately included. The mean prevalence of ovarian malignancy was 29.0% in premenopausal women and 51.0% in postmenopausal women. High risk of bias for patient selection was observed for most studies. ROMA and RMI-I had a similar diagnostic performance in postmenopausal women (pooled sensitivity [87 vs. 77%] and specificity [75 vs. 85%], respectively. p = 0.29). In premenopausal women, RMI-I showed better specificity than ROMA (89 vs. 78%, p = 0.022) with similar sensitivity (73 vs. 80%, p= 0.27). Significant heterogeneity was found for sensitivity and specificity in comparisons of both groups. Conclusions: ROMA and RMI-I have similar diagnostic performance for detecting ovarian cancer in women presenting with an adnexal mass. However, RMI-I showed a higher specificity than ROMA in premenopausal women. Notwithstanding, as the risk of bias is high in most studies, our results should be interpreted with caution.
Are There Any Predictors of Endometrial Premalignancy/Malignancy within Endometrial Polyps in Infertile Patients?
Authors: Tohma Yusuf Aytac , Onalan Gogsen , Esin Sertac , Sahin Hanifi , Aysun Dide , Kuscu Esra , Haberal Ali , Zeyneloglu Hulusi Bulent
Published: July 2019

Background: In the literature, there is no detailed analysis on the prediction factors for premalignancy/malignancy within endometrial polyps (EPs) in infertile patients. In this study, we aimed to determine the frequency of endometrial premalignancy/malignancy within EPs in infertile patients undergoing office hysteroscopic polypectomy and identify the factors that can potentially predict an endometrial premalignancy/malignancy within EPs. Method: A total of 957 infertile patients undergoing office hysteroscopy were diagnosed with EPs between February 2011 and August 2018. Patients were divided into 2 groups according to the pathological examination of EPs as benign (Group 1; n = 939) and premalignant/malignant (Group 2; n = 18). The medical records of all patients included in the study were reviewed retrospectively. Results: In this cohort, prevalence of endometrial premalignancy/malignancy within EPs was 18/957 (1.88%). On univariate analysis, age, polyp size, diabetes, hypertension, and causes of infertility did not differ between the 2 groups. On multivariate analysis, diffuse polypoid appearance of the endometrial cavity on office hysteroscopy (hazard ratio [HR] 4.1; 95% CI 1.576–10.785), duration of infertility, (HR 4; 95% CI 1.279–12.562), and body mass index (HR 7.9; 95% CI 2.591–24.258) were found to be independent predictors of endometrial premalignancy/malignancy within polyps in infertile patients. Conclusion: When diffuse polypoid appearance of the endometrial cavity is detected in an infertile patient during office hysteroscopy, hysteroscopy-guided resection and endometrial curettage should be performed. The pathological specimen should be sent for histopathological evaluation to diagnose possible endometrial premalignancy/malignancy within polyps.
A Case of Advanced Gastric Cancer with Peritoneal Metastasis Treated Successfully with Nivolumab
Authors: Tazawa Hirofumi , Suzuki Takahisa , Komo Toshiaki , Kubota Haruna , Tahara Shunya , Sada Haruki , Hadano Naoto , Shimizu Wataru , Ishiyama Kohei , Onoe Takashi , Sudo Takeshi , Shimizu Yosuke , Tashiro Hirotaka
Published: July 2019

Peritoneal metastasis (PM) is detected in 14% of gastric cancers at the time of initial diagnosis, with a median survival time of 4 months. A 66-year-old woman diagnosed with cT4a(SE) N2M1(LYN) cStage IV was treated with three lines of chemotherapy for a year. During the third line of chemotherapy, computed tomography (CT) scan revealed a large amount of ascites, periportal collar sign, and bilateral ureteral stenosis owing to PM. The tumor biomarkers (CEA and CA 19–9) remained elevated similar to the initial levels. The patient was administered 3 mg/kg nivolumab intravenously biweekly as the fourth line of chemotherapy. Three months after the nivolumab treatment, gastroscopy revealed an extreme reduction of the tumor size, while CT scan revealed the absence of ascites and a well-controlled tumor. There was no immune-related adverse event with nivolumab during and after the treatment, and performance status improved to 0. The patient has been alive for about 2.5 years since her first visit with her sixth line of chemotherapy (docetaxel). We report a case of advanced gastric cancer with PM that was treated successfully with nivolumab.
Pure Mucinous Breast Carcinoma with Micropapillary Pattern (MUMPC): A Case Report
Authors: Asano Yuka , Kashiwagi Shinichiro , Nagamori Mizuki , Tanaka Sayaka , Kuwae Yuko , Amano Ryosuke , Takashima Tsutomu , Ohsawa Masahiko , Hirakawa Kosei , Ohira Masaichi
Published: July 2019

Pure mucinous breast carcinoma with micropapillary pattern (MUMPC) was proposed as a new histopathological variant of pure mucinous carcinoma (PMC) with tumor cells forming a micropapillary architecture. The Classification of Tumours of the Breast by the World Health Organization, however, does not differentiate MUMPC as a distinct subtype. There is currently no consensus whether tumors that exhibit these features are classified as PMC or invasive micropapillary carcinoma (IMPC) with associated mucin production. A 45-year-old woman was examined for a tumor in her left breast. Upon physical examination, an elastic hard mass of around 5 cm along with accompanying skin flare and ulceration was palpated in the upper outer quadrant of the left breast. Mammary ultrasonography revealed a clearly marginated hypoechoic tumor of 55.0 × 46.9 × 37.0 mm in size in the upper outer quadrant of the left breast. A vacuum-assisted biopsy (VAB) was performed in the same site and histopathological diagnosis of PMC was made. Contrast-enhanced magnetic resonance imaging (MRI) showed a T1W1 low-intensity signal and a T2W1 high-intensity signal at the primary focus, ring enhancement of the tumor margin, and stranding enhancement inside the tumor. A preoperative diagnosis of left breast cancer (PMC), cT4bN1M0, stage IIIB, luminal B-like was made. We performed a simple mastectomy with axillary lymph node dissection. A 55.0 × 48.1 × 37.1 mm tumor with the gelatinous cut surface was excised. Histopathological examination of the excised specimen revealed mucin lake formation in the tumor containing clusters of atypical cells. The atypical cells showed swollen, irregular nuclei and a papillary growth pattern that lead to the diagnosis of MUMPC.
Inserting a Metallic Ureteral Stent Using an Antegrade Approach Freed a Patient from Nephrostomy Created due to Hydronephrosis Caused by Bladder Cancer
Authors: Kawahara Takashi , Takamoto Daiji , Miyoshi Yasuhide , Yao Masahiro , Uemura Hiroji
Published: July 2019

For the treatment of internal ureteral orifice invasion of bladder cancer, percutaneous nephrostomy is usually attempted initially. However, percutaneous nephrostomy reduces patients’ quality of day life. A 65-year-old man showed bilateral hydronephrosis due to locally advanced bladder cancer, and right percutaneous nephrostomy was created. After dilating the percutaneous nephrostomy, we inserted a metallic ureteral stent via an antegrade approach. We herein report a case of metallic ureteral stent insertion via an antegrade approach after initial creation of a nephrostomy, thus freeing the patient from nephrostomy.
A Neonate with Bicytopenia: Unusual Underlying Etiology
Authors: Elmelhat Ahmed Mohamed , Khadora Manal Mustafa
Published: July 2019

Although bicytopenia or pancytopenia is an uncommon presentation in the neonatal intensive care units setup, it still carries a wide range of differential diagnoses ranging from simple benign to complex malignant etiologies. We report an unusual etiology of a neonatal bicytopenia and discuss our approach of management.
Physiological Biomimetic Culture System for Pig and Human Heart Slices
Authors: Ou Qinghui , Jacobson Zoë , Abouleisa Riham R.E. , Tang Xian-Liang , Hindi Sajedah M. , Kumar Ashok , Ivey Kathryn N. , Giridharan Guruprasad , El-Baz Ayman , Brittian Kenneth , Rood Benjamin , Lin Ying-Hsi , Watson Samuel A. , Perbellini Filippo , McKinsey Timothy A. , Hill Bradford G. , Jones Steven P. , Terracciano Cesare M. , Bolli Roberto , Mohamed Tamer M.A.
Published: July 2019

Rationale:

Preclinical testing of cardiotoxicity and efficacy of novel heart failure therapies faces a major limitation: the lack of an in situ culture system that emulates the complexity of human heart tissue and maintains viability and functionality for a prolonged time.

Objective:

To develop a reliable, easily reproducible, medium-throughput method to culture pig and human heart slices under physiological conditions for a prolonged period of time.

Methods and Results:

Here, we describe a novel, medium-throughput biomimetic culture system that maintains viability and functionality of human and pig heart slices (300 µm thickness) for 6 days in culture. We optimized the medium and culture conditions with continuous electrical stimulation at 1.2 Hz and oxygenation of the medium. Functional viability of these slices over 6 days was confirmed by assessing their calcium homeostasis, twitch force generation, and response to β-adrenergic stimulation. Temporal transcriptome analysis using RNAseq at day 2, 6, and 10 in culture confirmed overall maintenance of normal gene expression for up to 6 days, while over 500 transcripts were differentially regulated after 10 days. Electron microscopy demonstrated intact mitochondria and Z-disc ultra-structures after 6 days in culture under our optimized conditions. This biomimetic culture system was successful in keeping human heart slices completely viable and functionally and structurally intact for 6 days in culture. We also used this system to demonstrate the effects of a novel gene therapy approach in human heart slices. Furthermore, this culture system enabled the assessment of contraction and relaxation kinetics on isolated single myofibrils from heart slices after culture.

Conclusions:

We have developed and optimized a reliable medium-throughput culture system for pig and human heart slices as a platform for testing the efficacy of novel heart failure therapeutics and reliable testing of cardiotoxicity in a 3-dimensional heart model.
Effect of Intensive and Standard Clinic‐Based Hypertension Management on the Concordance Between Clinic and Ambulatory Blood Pressure and Blood Pressure Variability in SPRINT
Authors: Ghazi Lama , Pajewski Nicholas M. , Rifkin Dena E. , Bates Jeffrey T. , Chang Tara I. , Cushman William C. , Glasser Stephen P. , Haley William E. , Johnson Karen C. , Kostis William J. , Papademetriou Vasilios , Rahman Mahboob , Simmons Debra L. , Taylor Addison , Whelton Paul K. , Wright Jackson T. , Bhatt Udayan Y. , Drawz Paul E.
Published: July 2019

Background

Blood pressure (
BP
) varies over time within individual patients and across different
BP
measurement techniques. The effect of different
BP
targets on concordance between
BP
measurements is unknown. The goals of this analysis are to evaluate concordance between (1) clinic and ambulatory
BP
, (2) clinic visit‐to‐visit variability and ambulatory
BP
variability, and (3) first and second ambulatory
BP
and to evaluate whether different clinic targets affect these relationships.

Methods and Results

The SPRINT (Systolic Blood Pressure Intervention Trial) ambulatory
BP
monitoring ancillary study obtained ambulatory
BP
readings in 897 participants at the 27‐month follow‐up visit and obtained a second reading in 203 participants 293±84 days afterward. There was considerable lack of agreement between clinic and daytime ambulatory systolic
BP
with wide limits of agreement in Bland‐Altman plots of −21 to 34 mm Hg in the intensive‐treatment group and −26 to 32 mm Hg in the standard‐treatment group. Overall, there was poor agreement between clinic visit‐to‐visit variability and ambulatory
BP
variability with correlation coefficients for systolic and diastolic
BP
all <0.16. We observed a high correlation between first and second ambulatory
BP
; however, the limits of agreement were wide in both the intensive group (−27 to 21 mm Hg) and the standard group (−23 to 20 mm Hg).

Conclusions

We found low concordance in
BP
and
BP
variability between clinic and ambulatory
BP
and second ambulatory
BP
. Results did not differ by treatment arm. These results reinforce the need for multiple
BP
measurements before clinical decision making.
Anglican Indigenization and Contextualization in Colonial Hong Kong: Comparative Case Studies of St. John’s Cathedral and St. Mary’s Church
Authors: Ellis James
Published: July 2019

The British Empire expanded into East Asia during the early years of the Protestant Mission Movement in China, one of history’s greatest cross-cultural encounters. Anglicans, however, did not accommodate local Chinese culture when they built St. John’s Cathedral in the British Crown Colony of Hong Kong. St. John’s had a prototypical English style and was a gathering place for the colony’s political and social elites, strengthening the new social order. The Cathedral spoke a Western architectural language that local residents could not understand and many saw Christianity as a strange, imposing, foreign religion. As indigenous Chinese Christians assumed leadership of Hong Kong’s Anglican Church, ecclesial architecture took on more Chinese elements, a transition epitomized by St. Mary’s Church, a Chinese Renaissance masterpiece featuring symbols from Taoism, Buddhism, and Chinese folk religions. This essay analyzes the contextualization of Hong Kong’s Anglican architecture, which made Christian concepts more relevant to the indigenous community.
Devario anomalus, a new species of freshwater fish from Bangladesh (Ostariophysi: Cyprinidae)
Authors: CONWAY KEVIN W. , MAYDEN RICHARD L. , TANG KEVIN L.
Published: July 2019

Devario anomalus, new species, is described from a small coastal stream south of Cox’s Bazar, Chittagong Division, Bangladesh. The new species can be distinguished from all other species of Devario by its unique colour pattern. It is further distinguished from all congeners reported from Bangladesh by a combination of characters, including its shorter P-stripe, the presence of maxillary barbels, an ascending process on the first infraorbital, and a lower number of lateral-line scales, branched dorsal-fin rays, branched anal-fin rays, and circumpeduncular scale rows.
Review of the genus Kuzicus Gorochov, 1993 (Orthoptera: Tettigoniidae: Meconematinae) from China
Authors: MAO SHAO-LI , HUANG YUAN , SHI FU-MING
Published: July 2019

A key to species of Kuzicus Gorochov, 1993 from China is presented. The generic diagnosis is redefined. One species is described as new: Kuzicus (Kuzicus) multifidous Mao & Shi sp. nov. The type specimens are deposited in Museum of Hebei University, Baoding.
Karyotype of the South African katydid Hetrodes pupus (Linnaeus, 1758) (Orthoptera, Tettigoniidae) with special reference to relationships within the Hetrodinae subfamily
Authors: WARCHAŁOWSKA-ŚLIWA ELŻBIETA , BUGROV ALEXANDER G.
Published: July 2019

The taxonomic position of Hetrodes pupus (Tettigoniidae, Hetrodinae) was clarified by a cytogenetic study of mitotic and meiotic chromosomes, including the localization of heterochromatin by C-banding. The karyotype of this species consists of 26 acrocentric autosomes and an acrocentric X chromosome, the largest element of the karyotype (2n male=27, FN=27; sex determination system is X0 male/XX female). A cytogenetic comparative analysis of the Hetrodinae and other katydids revealed (1) the similarity of the karyotypic features of Hetrodinae and Microtettigoninae, indicating monophyly; (2) that the morphology of the Hetrodinae karyotype is the result of parallel chromosome evolution via a decrease in the number of chromosome arms (FN).
Four new cunaxoidine genera (Acari: Prostigmata: Cunaxidae) and the description of two new Neotropical species
Authors: HEYER JACOB DEN , DE CASTRO TATIANE M. M. G.
Published: July 2019

In this paper the genus Cunaxoides Baker & Hoffmann, 1948, as delimited by Den Heyer (1979a, 1981b), is revised and divided into five genera, viz. Cunaxoides Baker & Hoffmann, Bunaxella gen. nov., Dunaxeus gen. nov., Funaxopsis gen. nov. and Qunaxella gen.nov.. Two new Neotropical species, Dunaxoides duosetosus and Qunaxella triasetosa are described and figured. Additional southern African material is reported. A key to the genera and species of the new genera of the subfamily Cunaxoidinae is provided.
Tanaidacea from Brazil. I. The family Tanaellidae Larsen & Wilson, 2002
Authors: LARSEN KIM , DE L. ARAÚJO-SILVA CATARINA , COELHO PETRÔNIO ALVES
Published: July 2019

Both male and female of two new species, i.e. Araphura arvedlundi n. sp. and Tanaella kroyeri n. sp. were collected from the continental slope of the Atlantic coast off northern Brazil and are described. This is the first record of the male of Araphura. An updated key is given to genus Araphura. Araphura io is transferred to the genus Araphuroides.
A revision of the genus Pulaeus Den Heyer, with descriptions of a new genus and four new Brazilian species (Acari: Prostigmata: Cunaxidae)
Authors: DE CASTRO TATIANE MARIE MARTINS GOMES , HEYER JACOB DEN
Published: July 2019

A new genus, Lupaeus gen. nov., is created to contain part of the described species in the genus Pulaeus Den Heyer. A key to the genera of the tribe Pulaeini, to which these two genera belong, and one auxiliary key to the species of Brazil and South Africa, are provided. Four new species, viz. Pulaeus myrtaceus sp. nov., P. quadrisolenidius sp. nov., Lupaeus lectus sp. nov. and L. lobidorsalis sp. nov. are described and figured. P. martini Den Heyer, 1981 is designated as type species for the new genus. New nomenclatural combinations are reported.
Studies in Liocranidae (Araneae): redescriptions and transfers in Apostenus Westring and Brachyanillus Simon, as well as description of a new genus
Authors: BOSSELAERS JAN
Published: July 2019

Three poorly known species of Apostenus Westring 1851 are redescribed: A. humilis Simon 1932, A. ochraceus Hadjissarantos 1940 and A. rutilius Simon 1897. A. rutilius is transferred to Agraecina Simon 1932 as A. rutilia new combination. The genus Brachyanillus Simon 1913 is synonymised with Cybaeodes Simon 1878 and B. liocraninus Simon 1913 is redescribed and transferred to Cybaeodes as C. liocraninus new combination. Arabelia pheidoleicomes gen. n., sp. n. (Araneae, Liocranidae) is described from Rhodos, Lesbos and Cyprus.
Six new, unusually small ants of the genus Leptomyrmex (Hymenoptera: Formicidae)
Authors: SMITH DEREK J. , SHATTUCK STEVE
Published: July 2019

The ant genus Leptomyrmex contains 41 named taxa which are limited to eastern Australia, New Guinea and New Caledonia. While most species are large and distinctive, a few species are much smaller and have only recently been recognised as belonging to this genus. These six species, informally called micro-Leptomyrmex, are restricted to rainforests and wet sclerophyll forests in two relatively small regions of eastern Australia. All are described here for the first time and include L. aitchisoni n. sp., L. burwelli n. sp., L. dolichoscapus n. sp., L. garretti n. sp., L. pilosus n. sp. and L. ramorniensis n. sp.
A new species of Hyalinobatrachium (Anura: Centrolenidae) from the Amazonian slopes of the central Andes, with comments on the diversity of the genus in the area
Authors: CASTROVIEJO-FISHER SANTIAGO , PADIAL JOSÉ M. , CHAPARRO JUAN C. , AGUAYO RODRIGO , DE LA RIVA IGNACIO
Published: July 2019

We describe a new species of Hyalinobatrachium from the Amazonian slopes of the Andes in Peru and Bolivia on the basis of morphological, bioacoustic and genetic characteristics. Hyalinobatrachium carlesvilai sp. nov. can be distinguished from other species of Hyalinobatrachium by the combination of the following characters: (1) truncate snout in dorsal and lateral view; (2) white pericardium; (3) enameled dorsal, tarsal and cloacal folds; (4) hand webbing formula III 2 – – 1 + IV; (5) iris cream; (6) advertisement call consisting of a single, frequency-modulated note with a pulsed section followed by a tonal section. The new species had been previously identified as Hyalinobatrachium munozorum and H. bergeri. The advertisement call of the new species was previously assigned to H. bergeri. Here we describe the previously unknown call of Hyalinobatrachium bergeri. Additionally, we study the taxonomic status of H. lemur and H. pellucidum and place the former as synonym of the later. We extend the distribution of H. pellucidum to Departamento Cusco in southern Peru.
Description of a new species of armored spider from Myanmar (Araneae: Tetrablemmidae)
Authors: LABARQUE FACUNDO M. , GRISMADO CRISTIAN J.
Published: July 2019

The Tetrablemmidae is a family of small to very small haplogyne, ecribellate, three-clawed spiders characterized mainly by the complex pattern of abdominal scuta (with dorsal, lateral and ventral plates) which justifies their common name “armoured spiders” (Shear 1978, Lehtinen 1981, Jocqué & Dippenaar-Schoeman 2006). They have a dorsal shield of prosoma heavily sclerotized, usually with rugous, pitted or reticulated surface, distinctly modified in the males of many genera. They lack direct eyes (anterior median), and several genera may lack some or all of the indirect eyes as well. One of the recognized tribes, Tetrablemmini (subfamily Tetrablemminae), contains the type genus of the family: Tetrablemma O. Pickard-Cambridge typically known by having four eyes displaced posteriorly in males, which have a convex clypeus, sometimes with tubercles, and chelicerae with anterior horns (Figs 6, 8─9; Lehtinen 1981: 56; Tong & Li 2008; Burger 2008).
Redescription of Parotocinclus bahiensis (Miranda-Ribeiro, 1918) (Pisces, Ostariophysi, Loricariidae)
Authors: BRITSKI HERALDO A. , GARAVELLO JULIO CESAR
Published: July 2019

Microlepidogaster bahiensis Miranda-Ribeiro (1918), assigned to Parotocinclus Eigenmann & Eigenmann, 1889, by Garavello (1977), was described in a short and uninformative way which does not allow for its distinction from other species of Parotocinclus; besides, the two syntypes of the species are regarded as lost. For these reasons a neotype is herein designated and a detailed description of the species is presented based on topotypes. The species is characterized by the combination of the following features: scapular bridge almost completely exposed ventrally, arrector fossae, when present, small or very reduced; abdomen covered by 5–7 wide lateral plates on each side and very small platelets in between, leaving abundant naked areas surrounding them; a small group of larger plates in front of anus; caudal peduncle ellipsoid in cross section; total plates in median series 21–23; longitudinal series with 23–26 plates; 18–29 teeth on premaxillary and 12–24 on dentary; it can also be distinguished by its characteristic caudal-fin color pattern. Features that allow us to assign the species to Parotocinclus and a hypothesis about its relationships with other species of the genus are also presented.
Erratum: Daly, M. & Ljubenkov, J.C. (2008) Edwardsiid sea anemones of California (Cnidaria: Actiniaria: Edwardsiidae), with descriptions of eight new species. Zootaxa, 1860, 1-27.
Authors: M. DALY , C. LJUBENKOV J.
Published: July 2019

(Erratum)
Notes on the genus Protohermes van der Weele (Megaloptera: Corydalidae) from Vietnam, with description of two new species
Authors: LIU XINGYUE , HAYASHI FUMIO , YANG DING
Published: July 2019

A faunistic review of the dobsonfly genus Protohermes van der Weele from Vietnam is presented, with 13 species recorded. Amongst them, three species, Protohermes differentialis (Yang & Yang, 1986), Protohermes lii Liu, Hayashi & Yang, 2007, and Protohermes triangulatus Liu, Hayashi & Yang, 2007, are newly recorded. Two species are described as new to science: Protohermes ishizukai sp. nov. and Protohermes sinuolatus sp. nov. Neurhermes guangxiensis Yang & Yang, 1992 and Protohermes basiflavus Yang, 2004 are synonymized with Protohermes differentialis (Yang & Yang, 1986) and Protohermes striatulus Navás, 1926, respectively. A key to the Vietnamese species of Protohermes is also provided.
Etymology of Triatomine Species (Hemiptera: Reduviidae: Triatominae)
Authors: GONÇALVES TERESA CRISTINA MONTE , NOVO SHÊNIA PATRÍCIA CORRÊA , LOPES CATARINA MACEDO , SANTOS-MALLET JACENIR REIS DOS
Published: July 2019

Systematics is the branch of biology in which the groupings and biodiversity of living organisms are studied and identified, and its most notable fields are classification and nomenclature. In the present study, 112 species of triatomines for which the original descriptions could be accessed are listed. Among these descriptions, the etymology of the species name has only been mentioned for 82 species. Of these, 14 species form part of the Entomological Collection of the Oswaldo Cruz Institute, the Herman Lent Entomological Collection of FIOCRUZ, and the Rodolfo Carcavallo Entomological Collection of FIOCRUZ. Sixty-six species were named after people, of whom 13 had worked at the Oswaldo Cruz Institute. In an attempt to gather together all this information, this study reports the origins of some of these species names, with their respective bibliographic references according to the original descriptions.
Neotropical Mecoptera (Insecta): New generic synonymies, new combinations, key to families and genera, and checklist of species
Authors: MACHADO RENATO JOSE PIRES , GODOI FABIO SIQUEIRA P. , RAFAEL JOSÉ ALBERTINO
Published: July 2019

Two Neotropical genera of Mecoptera (Thyridates Navás, 1908, Neobittacus Esben–Petersen, 1914 n. syn.) are synonymized under Bittacus Latreille, 1805. The following are new combinations: Bittacus aripuanaensis (Penny, 1977) n. comb., B. brunnipenis (Collucci & Amorim, 2000) n. comb., B. froehlichi (Collucci & Amorim, 2000) n. comb., B. latreillei (Collucci & Amorim, 2000) n. comb., B. novokschonovi (Petrulevičius, 2003) n. comb. and B. willmanni (Collucci & Amorim, 2001) n. comb.. A pictorial key to Neotropical families and genera and a checklist of Neotropical species are presented.
Biological synopsis of Photocryptus Viereck (Hymenoptera, Ichneumonidae, Cryptinae), with eight new host records and fourteen new geographic records
Authors: AGUIAR ALEXANDRE P. , SANTOS BERNARDO F.
Published: July 2019

The host records of Photocryptus Viereck are revised. Nine species from seven genera and four families, all aculeate Hymenoptera, are recognized as hosts for species of Photocryptus. Published host records were compiled for three species, and eight new records are provided for four species, as follows: P. concinnus (Brullé) is parasitoid of Auplopus militaris (Lynch-Arribalzaga) (Pompilidae, Pepsinae) new record, Sceliphron assimile (Dahlbom) (Sphecidae, Sceliphrinae), new record, and Trypoxylon maidli Richards (Crabronidae, Trypoxyloninae), new record; P. fumatus (Hancock) is parasitoid of Santamenes novarae (Saussure) (Vespidae, Eumeninae), and Sceliphron assimile, new record; P. pachymenae (Cresson) is parasitoid of Pachymenes sp. (Vespidae, Eumeninae), and Sceliphron fistularium (Dahlbom); P. photomorphus Viereck is parasitoid of Sceliphron sp. and Brachymenes dyscherus (Saussure) (Vespidae, Eumeninae); P. testaceoniger (Taschenberg) is parasitoid of Sceliphron fistularium, new record; P. testaceus (Taschenberg) is parasitoid of Sceliphon fistularium, new record, Trypoxylon albitarse Fabricius, new record, and T. nitidum F. Smith, new record. A non-identified species of Photocryptus is recorded in the literature parasiting Trigonopsis violascens Dalla Torre (Sphecidae, Sceliphrinae). Original data provides the first evidence of two species of Photocryptus attacking the same host nest, namely P. testaceoniger and P. testaceus on a nest of S. fistularium; ovipositor length vs. nest dimensions are also compared for these species, suggesting either incidental attack or avoidance of confrontation behavior. Fourteen new geographic records are provided for seven species.
New mite species of the genus Cunaxa (Acari: Prostigmata: Cunaxidae) from the Crimea, Ukraine
Authors: SERGEYENKO ALEXEY L.
Published: July 2019

Six new mite species of the genus Cunaxa Von Heyden, 1826 from the Crimean Peninsula (Ukraine), viz. C. gordeevae sp. nov., C. guanotoleranta sp. nov., C. maculata sp. nov., C. papuliphora sp. nov., C. violaphila sp. nov. and C. yaylensis sp. nov. are described and figured. A key to species of Cunaxa from the Crimea, all having a single dorsal propodosomal plate in the female, is provided.
Revisiting the Brazilian fauna of masarine wasps: new records, an illustrated key to species and a description of the male of Trimeria rubra Hermes & Melo (Hymenoptera: Vespidae: Masarinae)
Authors: HERMES MARCEL G. , GARCETE-BARRETT BOLÍVAR R.
Published: July 2019

An overview of the Brazilian fauna of pollen wasps (Hymenoptera: Vespidae: Masarinae) is made: an illustrated key for all species recorded or potentially occurring in the country is provided; the male of Trimeria rubra Hermes & Melo is described; two species (Ceramiopsis paraguayensis Bertoni and T. bequaerti Willink) are newly recorded for Brazil; three species (Paramasaris richardsi (Giordani Soika), T. rubra and T. robusta Hermes & Melo) are newly recorded for Brazilian states and flower records are given for T. rubra for the first time.
New species of Nepalomyia from China (Diptera: Dolichopodidae)
Authors: WANG MENGQING , YANG DING , GROOTAERT PATRICK
Published: July 2019

The following six new species of the genus Nepalomyia are described and illustrated: Nepalomyia fogangensis sp. nov., N. guangdongensis sp. nov., N. hastata sp. nov., N. jinshanensis sp. nov., N. xui sp. nov., and N. zhangae sp. nov. N. xui sp. nov. belongs to the trifurcata group, N. guangdongensis sp. nov., N. hastata sp. nov. N. jinshanensis sp. nov., and N. zhangae sp. nov. belong to the henanensis group; but the remaining species cannot be placed into any known species group. Keys for Chinese species of trifurcata group and henanensis group are presented.
Annotated check-list, generic key and new species of Old World Deltocephalini leafhoppers with nomenclatorial changes in the Deltocephalus group and other Deltocephalinae (Hemiptera, Auchenorrhyncha, Cicadellidae)
Authors: WEBB MICHAEL D. , VIRAKTAMATH CHANDRA A.
Published: July 2019

An annotated check-list and generic key to Old World members of the grassland leafhopper tribe Deltocephalini are provided. The Deltocephalus group of genera are discussed and one of the included genera, Recilia Edwards, is revised to include only two species, coronifer (Marshall) (= coroniceps Kirschbaum) and raoi (Dash & Viraktamath), comb. nov. (from Deltocephalus (Recilia)). All other species of Recilia are placed in Maiestas Distant, 1917, resulting in several new combinations (see species lists under Maiestas) and the following new junior synonyms of Maiestas: Togacephalus Matsumura 1940 syn. nov., Inazuma Ishihara, 1953, syn. nov., Inemadara Ishihara, 1953, syn. nov., and Insulanus Linnavuori, 1960a, syn. nov. The following additional new nomenclatorial changes are proposed (all new combinations from Deltocephalus): Athysanini: Allophleps eques (Jacobi), comb. nov., Bampurius melichari (Distant), comb. nov., Monobazus fuscovarius (Distant), comb. nov., Okaundua ornatula (Melichar) comb. nov.; Paralimnini: Wakaya angustus (Melichar), comb. nov., Wakaya severa (Melichar), comb. nov., Vilargus campanus (Naudé), comb. nov., Platentomus aristida (Cogan), comb. nov.; Stenometopiini: Stirellus coloratus (Distant), comb. nov., Stirellus laetus (Melichar), comb. nov., Stirellus rufolineatus (Melichar), comb. nov. , Deltocephalus alacer Stål, 1859, junior synonym of Hecalus porrectus (Walker, 1858), syn. nov., Thamnotettix prabha Pruthi, 1930: 62, junior synonym of Maiestas maculata (Pruthi, 1930: 58-59), syn. nov. Polyamia drepananiforma Zhang & Duan, 2004, junior synonym of Matsumuratettix hiroglyphicus Matsumura, 1914, syn. nov., Scaphoideus seychellensis Distant, 1917, junior synonym of Maiestas vagans (Distant, 1917), syn. nov., Recilia dolabra Kramer, August 1962 and R. jordanica Dlabola, 1965, junior synonyms of Maiestas angustisecta (Linnavuori, 20th August 1962), syn. nov., Deltocephalus immaculatus Melichar, 1914, status revised from Deltocephalus porticus immaculatus Melichar. In addition, Pingellus Evans (1966) and Occiplanocephalus Evans (1942) are transferred from Deltocephalini to Athysanini (new placements) and three new species (Maiestas dashi sp. nov., M. knighti sp. nov. and Paramesodes iraniensis sp. nov.) are described with figures provided for these and other species.
Morphology of the complete larval stages of Portunus segnis (Forskål, 1775) (Crustacea: Brachyura: Portunidae) from the Gulf of Aqaba, Saudi Arabia
Authors: AL-AIDAROOS ALI M. , KUMAR A. A. J. , AL-HAJ AHMED E. , AL-SOFYANI ABDULMOHSIN , CROSBY MICHAEL P. , EL-SHERBINY MOHSEN M.
Published: July 2019

Portunus pelagicus (Linnaeus, 1758) sensu lato has been recognized as a species complex comprising four species. Of these four species, the larval stages of all except Portunus segnis (Forskål, 1775), have been described. The larvae of P. segnis, hatched from an ovigerous female, caught in the Gulf of Aqaba, were cultured in the laboratory up to the megalopa stage. All the larval stages are described herein for the first time. The number of aesthetascs of the antennules of all the zoeal stages of P. segnis differs from those of the larvae of the other species of the P. pelagicus species complex. In the telson forks of zoea I–IV of P. segnis, there is a pair of ventral spines and two pairs of dorsal spines, whereas in the other P. pelagicus species complex larvae, there is a pair each of ventral and dorsal spines. Another unique feature, in the megalopa of P. segnis, are two endopod hooks in pleonites I–V. Different zoeal and megalopal stages of P. segnis can be distinguished clearly from the other P. pelagicus species complex larvae based on the number of setae and patterns of different appendages.