bluuebunny/crossref_metadata_2025 huggingface dataset:
Living in the Age of Deepfakes: A Bibliometric Exploration of Trends, Challenges, and Detection Approaches
Authors: Domenteanu Adrian , Tătaru George-Cristian , Crăciun Liliana , Molănescu Anca-Gabriela , Cotfas Liviu-Adrian , Delcea Camelia
Published: August 2024

In an era where all information can be reached with one click and by using the internet, the risk has increased in a significant manner. Deepfakes are one of the main threats on the internet, and affect society by influencing and altering information, decisions, and actions. The rise of artificial intelligence (AI) has simplified the creation of deepfakes, allowing even novice users to generate false information in order to create propaganda. One of the most prevalent methods of falsification involves images, as they constitute the most impactful element with which a reader engages. The second most common method pertains to videos, which viewers often interact with. Two major events led to an increase in the number of deepfake images on the internet, namely the COVID-19 pandemic and the Russia–Ukraine conflict. Together with the ongoing “revolution” in AI, deepfake information has expanded at the fastest rate, impacting each of us. In order to reduce the risk of misinformation, users must be aware of the deepfake phenomenon they are exposed to. This also means encouraging users to more thoroughly consider the sources from which they obtain information, leading to a culture of caution regarding any new information they receive. The purpose of the analysis is to extract the most relevant articles related to the deepfake domain. Using specific keywords, a database was extracted from Clarivate Analytics’ Web of Science Core Collection. Given the significant annual growth rate of 161.38% and the relatively brief period between 2018 and 2023, the research community demonstrated keen interest in the issue of deepfakes, positioning it as one of the most forward-looking subjects in technology. This analysis aims to identify key authors, examine collaborative efforts among them, explore the primary topics under scrutiny, and highlight major keywords, bigrams, or trigrams utilized. Additionally, this document outlines potential strategies to combat the proliferation of deepfakes in order to preserve information trust.
Consumption and Digestion of Plastics by Greater Hive Moth Larvae
Authors: Arias-González Andrés Felipe , Gómez-Méndez Luis David , Sáenz-Aponte Adriana
Published: August 2024

The accumulation and unsustainable management of plastic waste generate environmental pollution that affects ecosystems, wildlife, and human health. We studied the possibility of using the consumption and digestion of oxo-biodegradable, compostable plastics and polypropylene from face masks by the fifth-instar larvae of G. mellonella as a strategy for the sustainable management of plastic waste. We used Fourier transform infrared spectrophotometry (FTIR) to determine the percentage of consumption and presence of microplastics in the digestive tract and excreta for 10 treatments evaluated for 135 h. The effects of plastics on the continuity of the life cycle of the greater hive moth were also determined. We established that the larvae fragmented and consumed 35.2 ± 23% of the plastics evaluated, with significant differences between treatments. Larvae were able to consume more of the intermediate layers of masks (86.31%) than the other plastics. However, none of the plastics were digested. Instead, microplastics accumulated in the excreta, resulting in nutritional deficits that affected the continuity of the life cycle, including the induction of the early formation of pupae after 24 h and a reduction in the number of eggs laid by the females.
Severe Cognitive Impairment in Trauma-Affected Refugees—Exploring the Impact of Traumatic Brain Injury
Authors: Nordin Linda , Bothe Søren Kit , Perrin Sean , Rorsman Ia
Published: August 2024

Background/Objectives: This study explores the relationship between cognitive performance measured by the Symbol Digit Modality Test (SDMT) and the severity of self-reported head injury, traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), depression, pain, and psychosocial dysfunction in a population of trauma-affected refugees. Refugees, especially those who have been subjected to torture, often face various difficulties, such as PTSD, depression and somatic disturbances (e.g., pain), which can significantly impact their day-to-day functioning. Methods: Participants included 141 adult refugees (38% women) with a mean age of 45.4 years (SD = 9.4) and 9.7 years (SD = 4.9) of education who were referred for treatment of post-traumatic distress to DIGNITY, Danish Institute Against Torture. Participants completed standardized self-report measures of PTSD, anxiety, depression, pain, and health-related disability and measures of trauma history, physical injuries including head injury and loss of consciousness, and the SDMT, a quick standardized performance-based measure of cognitive impairment. Results: Eighty-eight percent of participants evidenced signs of substantial cognitive impairment as indexed by lower SDMT scores. Those with a self-reported history of TBI, marked by loss of consciousness, exhibited lower SDMT scores and higher health-related disabilities. Severity of PTSD, depression, anxiety, and pain were highly correlated with lower SDMT scores. TBI history was not significantly associated with the severity of PTSD, depression, anxiety, or pain, suggesting a complex interplay among these factors. Conclusions: Cognitive impairments are prevalent in trauma-affected refugees, interacting with symptoms of post-traumatic stress and pain, likely explaining the high disability levels in this population. Further research should employ a broader range of cognitive measures and detailed investigations of head injury/TBI experiences to investigate their impact on overall functioning, treatment response, and longer-term outcomes. This study adds to a small but growing body of studies documenting cognitive impairments in trauma-affected refugees, highlighting the importance of addressing cognitive impairments in treatment for trauma-affected refugees, particularly those with histories of torture and TBI. Clinicians working with trauma-affected refugees should consider the assessment of cognitive difficulties as part of comprehensive care planning.
Comparative Effects of Neurodynamic Slider and Tensioner Mobilization Techniques on Sympathetic Nervous System Function: A Randomized Controlled Trial
Authors: Papacharalambous Charalambos , Savva Christos , Karagiannis Christos , Paraskevopoulos Eleftherios , Pamboris George M.
Published: August 2024

Objective: To investigate the effect of slider and tensioner neurodynamic techniques (NDTs) on the sympathetic nervous system (SNS) activity, aiming to identify which technique more effectively modulates autonomic responses in asymptomatic individuals. Materials and Methods: In this double-blind controlled trial, a total of 90 healthy participants were randomly allocated into three groups: slider, tensioner, and control. Skin conductance (SC) was continuously monitored throughout the entire 20 min experiment, while body temperature and blood pressure were measured pre- and post-intervention. Results: The SC levels significantly increased in both the slider and tensioner groups compared to the control group during the intervention and end rest period on the left leg (slider vs. control: p < 0.001, d = 1.20; tensioner vs. control: p < 0.001, d = 1.64) and on the right leg (slider vs. control: p < 0.001, d = 1.47; tensioner vs. control: p < 0.001, d = 0.73). There were no significant differences between the two NDTs on the left (p < 0.13, d = 0.89) and right legs (p < 1.00, d = 0.36). The body temperature of the slider group showed a significant increase compared to both the control group (p < 0.001, d = 0.95) and the tensioner group (p < 0.001, d = 1.48). There were no significant differences between the groups in systolic (p = 0.95) or diastolic blood pressure (p = 0.06). There were no side-specific effects on SNS activity between the left and right legs (p < 0.019) during all intervention phases. Conclusions: Significant sympathoexcitatory responses were elicited by both slider and tensioner NDTs in asymptomatic participants, demonstrating their efficacy in modulating the SNS. The differences between the two techniques were not statistically significant; however, the tensioner NDT showed a slightly more pronounced effect, suggesting that the tensioner NDT can be considered superior in terms of overall SNS effect. These findings indicate that both techniques may have the potential to enhance autonomic regulation in clinical practice; however, the tensioner NDT may be more effective. The consistent responses across participants highlight the systemic benefits of NDTs, providing a foundation for further research into their application in symptomatic populations. This study contributes to evidence-based practice by providing baseline data that support the development of theoretical frameworks and aid in clinical decision-making.
A New Self-Expandable Metallic Stent with Low Axial Force and a High Axial Force Zero-Border Shows a Very Low Perforation Rate in Malignant Colorectal Obstruction: A Japanese Multicenter Prospective Study
Authors: Murakami Takashi , Isayama Hiroyuki , Ikeda Satoshi , Hanabata Norihiro , Enomoto Toshiyuki , Kuwai Toshio , Ushigome Mitsunori , Ebi Masahide , Ohtsuka Hideo , Endo Shungo , Saito Shuji , Ohki Takeshi , Yamamoto Ryuichi , Kayahara Takahisa , Matsumoto Satoshi , Sasaki Yoshihiro , Saida Yoshihisa
Published: August 2024

Background: Recently, there has been a significant increase in the utilization of self-expandable metallic stents (SEMSs) for treating malignant colorectal obstructions through colorectal stenting. The mechanical properties of SEMSs are usually considered to affect clinical outcomes of patients with malignant colorectal obstructions. Methods: This single-arm, prospective, multicenter study of SEMS with a lower axial force and high axial force zero-border included 200 patients with malignant colorectal obstruction. Technical and clinical success, stent patency, and adverse events associated with SEMS placement were evaluated. Results: One patient was excluded, and 199 patients were evaluated. The treatment intent was bridge-to-surgery in 129 and palliation in 70 patients. Technical and clinical success rates were 99.5% and 97.0%, respectively. The percentage of the ColoRectal Obstruction Scoring System scores of 3 or higher improved significantly from 19.2% before placement to 93.9% after placement. Clinical success was not achieved in five patients due to insufficient stent expansion in four patients and stent occlusion in one patient. Only one patient underwent emergency surgery for perforation of the proximal colon, far from where the stent was placed; the rescue procedure was not performed, despite no improvement in proximal dilatation due to insufficient stent expansion. Among the palliation cohort, 15 patients received chemotherapy, including molecular-targeted agents such as bevacizumab. There were no fatal cases related to stent placement. Conclusions: For management of malignant colorectal obstruction, this newly developed SEMS with low axial force and a high axial force zero-border showed high technical and clinical success rates, and an extremely low perforation rate (0.5%).
Metabolic Risk in Patients with a Diminished Ovarian Reserve and Premature Ovarian Insufficiency
Authors: Robeva Ralitsa , Elenkova Atanaska , Kirilov Georgi , Zacharieva Sabina
Published: August 2024

Objective: Diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI) represent conditions of different severity, characterized by an earlier-than-expected decrease in ovarian activity. The present study aims to compare metabolic disturbances between women with DOR and patients with POI from a different origin. Materials and methods: A total of 226 women (28 healthy women; 77 individuals with DOR, and 121 patients with POI/36 with Turner syndrome [TS] and 85 with non-TS POI/) have been studied retrospectively. Data concerning anthropometric indices, and metabolic parameters were collected. Results: Patients with DOR, non-TS POI, and TS had increased blood pressure and liver enzymes, pronounced insulin resistance, and worse lipid profiles than controls (p < 0.008 for all). TS patients had significantly higher ASAT, GGT, and TSH levels compared to non-TS POI and DOR individuals. The prevalence of type 2 diabetes tended to be higher in TS women compared to other groups. The prevalence of previously diagnosed polycystic ovarian syndrome was lower in the non-TS POI patients than in the DOR patients (p = 0.005). Conclusions: patients with decreased ovarian function suffer from insulin resistance, abnormal lipid profile, and subtle hepatic disturbances, irrespective of the severity of the condition and the presence of chromosomal aberrations.
Locking Plate Fixation with Calcium Phosphate Bone Cement Augmentation for Elderly Proximal Humerus Fractures—A Single-Center Experience and Literature Review
Authors: Peng Chun-Chi , Tai Ting-Han , Chen Chih-Yu
Published: August 2024

Proximal humerus fractures (PHFs) are among the most common upper-extremity fractures, with a rising incidence linked to the growing elderly population. Treatment options include non-surgical and surgical methods, but the best approach for geriatric PHFs remains debated. Patient selection for treatment must consider clinical and functional outcomes and the potential complications of surgery. Osteoporosis, a key factor in elderly PHFs, meaning those in patients over 65 years old, often results from low-energy trauma and necessitates treatments that enhance bone healing. Bone cement, such as calcium phosphate, is widely used to improve fracture stability and healing. However, the benefits of surgical fixation with bone cement augmentation (BCA) for elderly PHF patients remain controversial. Hence, in this article, we searched databases including MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science to analyze the evidence on locking plate fixation (LPF) with BCA for proximal humeral fractures. We aim to provide readers with updates concerning the above issues.
Biomarkers of Internet Gaming Disorder—A Narrative Review
Authors: Skok Katarzyna , Waszkiewicz Napoleon
Published: August 2024

Since game mechanics and their visual aspects have become more and more addictive, there is concern about the growing prevalence of Internet gaming disorder (IGD). In the current narrative review, we searched PubMed and Google Scholar databases for the keywords “igd biomarker gaming” and terms related to biomarker modalities. The biomarkers we found are grouped into several categories based on a measurement method and are discussed in the light of theoretical addiction models (tripartite neurocognitive model, I-PACE). Both theories point to gaming-related problems with salience and inhibition. The first dysfunction makes an individual more susceptible to game stimuli (raised reward seeking), and the second negatively impacts resistance to these stimuli (decreased cognitive control). The IGD patients’ hypersensitivity to reward manifests mostly in ventral striatum (VS) measurements. However, there is also empirical support for a ventral-to-dorsal striatal shift and transition from goal-directed to habitual behaviors. The deficits in executive control are demonstrated in parameters related to the prefrontal cortex (PFC), especially the dorsolateral prefrontal cortex (DLPFC). In general, the connection of PFC with reward under cortex nuclei seems to be dysregulated. Other biomarkers include reduced P3 amplitudes, high-frequency heart rate variability (HRV), and the number of eye blinks and saccadic eye movements during the non-resting state. A few studies propose a diagnostic (multimodal) model of IGD. The current review also comments on inconsistencies in findings in the nucleus accumbens (NAcc), anterior cingulate cortex (ACC), and precuneus and makes suggestions for future IGD studies.
Possible Correlation between Mucin Gene Expression and Symptoms of Dry Eye Syndrome Secondary to Sjogren’s Disease
Authors: Brossard-Barbosa Natalie , Agoglia Matias , Vergara Maria Elena , Costa Monique , Cairoli Ernesto , Freire Teresa
Published: August 2024

(1) Background: It is estimated that 10% of dry eye disease (DED) occurs in patients with Sjogren’s syndrome (SS-DED) and represents a challenge when it comes to treatment. Both innate and adaptive immunity participate in the pathogenesis of SS-DED. Previous studies suggest that Th1 and Th17 cell immune responses are the main actors associated with the pathogenesis of this disease. Ocular surface mucins play a fundamental role in ocular surface homeostasis. In particular, the main transmembrane mucins, MUC1, MUC4 and MUC16, are dysregulated in DED and could be involved in the activation of pro-inflammatory cytokines at the ocular interface. Thus, the objective of this work was to analyze mucin and cytokine expression in ocular surface (OS) damage and correlate it with clinical symptoms.; (2) Methods: 18 patients with SS-DED and 15 healthy controls were included in the study. Samples of conjunctival cells were obtained through cytology impression. RNA was extracted from the collected samples and used to determine the expression of MUC1, 4 and 16 by qRT-PCR. Pro-inflammatory cytokines associated with DED pathogenesis (IL17 and IL-22) were also evaluated. The results were contrasted with the clinical findings on examination of the patients. (3) Results: We observed a significant increase in the expression of MUC1 and MUC4 in patients with SS-DED. MUC4 significantly correlated with both lower production and stability of the tear film, as well as greater superficial keratopathy. On the other hand, MUC1 and MUC16 were positively correlated with the presence of more severe DED symptoms. However, we could not reproduce an increase in IL-17 and IL-22 in DED patients as previously reported; (4) Conclusions: This work constitutes an approach to understanding how the gene expression of transmembrane mucins associates with SS-DED symptoms and clinical signs.
1-Year Prevalence and Factors Related to Injuries and Illnesses in Japanese Judo Collegiate Athletes
Authors: Kinoda Akira , Mącznik Aleksandra , Kimura Takeshi , Muramoto Yuki , Katsumata Yoshinori , Sato Kazuki
Published: August 2024

Despite its rich history and widespread participation, the research surrounding injuries and illness in judo remains relatively limited compared to other sports. The primary aim of this research was to investigate injuries and illness within a previous year in Japanese collegiate judo athletes and analyze possible factors associated with these. This was a cross-sectional observational study using a web-based survey to collect data on the 1-year prevalence of injuries and illness. This study involved 564 judo athletes (67% males), aged between 18 and 25 years. Of these, 344 athletes (61%) reported one or more injuries within the previous year, and 49 reported illness (9%). The more judo experiences the athlete acquired, the less likely they were to sustain an injury (OR: 0.9; 95% CI: 0.56–1.10; p-value < 0.05) or illness (OR: 0.9; 95% CI: 0.81–1.00; p-value < 0.05). Support of an athletic trainer was associated with 1.7 times increased odds of sustaining an injury (95% CI: 1.19–2.49; p-value < 0.05). Athletes with obese BMI status (BMI > 30) had 3.1 times higher odds of becoming ill (95% CI: 1.41–6.95; p-value = 0.005), and athletes training more than 5 days per week had the odds of becoming ill increased by 5.1 times (95% CI: 1.11–23.21; p-value = 0.036). Judokas with fewer years of experience and with obese status should be targeted in efforts to prevent injury and illness. Moreover, the support of an athletic trainer and the impact of weekly training days should be targeted in research efforts.
How Match-Related Variables Influence the Physical Demands of Professional Female Soccer Players during the Regular Season
Authors: Marcelli Lorenzo , Silvestri Fioretta , Di Pinto Gianluca , Gallotta Maria Chiara , Curzi Davide
Published: August 2024

To investigate how contextual or environmental factors may influence the athletic performance of female soccer players during competitions, this study aimed to assess the impact of match-related variables (playing surface; opponent levels; opponent result trends; match status, and match outcomes) on the athletic performance of professional female soccer athletes. Seventeen athletes (25.5 ± 4.3 years of age) from the same team competing in the Italian second division were divided into two groups according to their roles and athletic characteristics: Group A (central defenders and forwards) and Group B (right/left full-backs and midfielders). Total distance (TD) and sprint distance (SD); high-speed running (HSR), acceleration (ACC), and deceleration numbers (DEC); average and maximal heart rate (HR_avg; HR_max); and match-related factors were collected during the 22 regular season matches. A T-test and ANOVA were used to calculate the differences between groups in GPS and HR variables and the effects of match-related factors, respectively. Results showed higher running performance in the B group compared to the A group during matches. Increased ACC number was seen in matches played on artificial turf; winning was associated with decreased HR_max and increased DEC number. Athletes covered higher TD reaching lower HR_max when playing against lower-ranking opponents while matches lost/drawn resulted in higher HSR. High HRs (max and avg) were found when playing against a team with a positive performance trend. In summary, match-related factors and opponents’ characteristics can affect athletic performance in female soccer athletes. These factors should be considered during in-seasonal training to personalize match preparation and optimize athlete performance.
Sediment Types with Alternation of Sandy and Rocky Shores Influence the Distribution of Clams in an Area Characterized by High-Energy Hydrodynamic Conditions
Authors: Dauvin Jean-Claude , Basuyaux Olivier , Pezy Jean-Philippe
Published: August 2024

To identify short-term changes (14–69 days) in the adult abundance of two closely related shallow-burrowing bivalves (Ruditapes spp.), a series of observations and displacement assessments were made during the 2014–2018 period. This study was initiated to estimate the natural displacement of clams in a high-energy hydrodynamic tidal regime along the western coast of Cotentin in Normandy, France (western basin of the English Channel, northeastern Atlantic). The raking of several different surfaces and sediment types at successive periods separated by about one month shows clam displacement in most of the selected quadrats. The mean abundance displacement derived from all the observations carried out in 2014, 2016 and 2018 is estimated at 1.8 ind·m−2 mo−1, a value that should be compared with the mean density of between 2.0 and 12.5 ind·m−2 along the western coast of Cotentin. These displacements are confirmed with experiments using clams marked with an inox metal washer and detected with a Minelab Sovereign GT multi-frequency metal detector. During the course of the experiments, about 20% of the clams show a displacement. Most of the displacements are moderate, being less than 2 m, but some clams could be displaced by more than 20 m.
Adaptive Transmission Interval-Based Self-Triggered Model Predictive Control for Autonomous Underwater Vehicles with Additional Disturbances
Authors: Zhang Pengyuan , Hao Liying , Wang Runzhi
Published: August 2024

Most existing model predictive control (MPC) methods overlook the network resource limitations of autonomous underwater vehicles (AUVs), limiting their applicability in real systems. This article addresses this gap by introducing an adaptive transmission, interval-based, and self-triggered model predictive control for AUVs operating under ocean disturbances. This approach enhances system stability while reducing resource consumption by optimizing MPC update frequencies and communication resource usage. Firstly, the method evaluates the discrepancy between system states at sampling instants and their optimal predictions. This significantly reduces the conservatism in the state-tracking errors caused by ocean disturbances compared to traditional approaches. Secondly, a self-triggering mechanism was employed, limiting information exchange to specified triggering instants to conserve communication resources more effectively. Lastly, by designing a robust terminal region and optimizing parameters, the recursive feasibility of the optimization problem is ensured, thereby maintaining the stability of the closed-loop system. The simulation results illustrate the efficacy of the controller.
The Perspective of Romanian Patients on Continuous Therapy for Multiple Myeloma
Authors: Irimia Ruxandra , Badelita Sorina Nicoleta , Barbu Sinziana , Zidaru Larisa , Carlan Ioana Loredana , Preda Oana Diana , Coriu Daniel
Published: August 2024

The treatment paradigm of multiple myeloma (MM) has shifted in the past years, as continuous therapy is becoming the standard of care for both newly diagnosed and relapsed patients. Although it is indisputable that continuous therapy has added a great benefit on the progression-free as well as overall survival, it is still unclear what the patients’ perspective is on this therapeutic approach. Methods: This study included 155 adult MM patients from Fundeni Clinical Institute in Romania, receiving continuous therapy with daratumumab, proteasome inhibitors, immunomodulators, or bi-specific antibodies. The patients had varied economic, social, and educational backgrounds. We developed a questionnaire to interrogate the quantitative and qualitative effect of the therapy on the patients’ personal and professional life and to identify the side effects that had the strongest impact on their quality of life. Results: 74.83% of the patients reported that the treatment they received negatively impacted their quality of life. Among them, 40% considered that the most detrimental aspects of the therapy are the financial burden and the negative impact on their professional life. One-third of the patients reported that the therapy negatively impacted their personal life and that it had a deleterious effect on their relationship with their partner and family members. In terms of the side effects experienced, patients considered that tiredness was the main factor causing a decrease in their quality of life, followed by insomnia and bone pain. Despite this, almost none of the patients considered dropping the therapy, and almost half of the patients considered that the frequent visits to the hospital offered them psychological comfort. In addition, more than 70% of the patients declared that they were afraid to stop the therapy if given the choice, with the main concerns being the fear of an early relapse. Conclusions: Although continuous therapy is associated with a high financial burden and a negative impact on both professional and personal life, the frequent visits to the hospital appear to be reassuring. Moreover, the patients would not opt for treatment discontinuation and felt safer when monitored frequently.
Ovarian Hyperstimulation Syndrome (OHSS): A Narrative Review and Legal Implications
Authors: Gullo Giuseppe , Cucinella Gaspare , Stojanovic Vukasin , Stojkovic Mirjana , Bruno Carmine , Streva Adriana Vita , Lopez Alessandra , Perino Antonio , Marinelli Susanna
Published: August 2024

Background: Infertility is a highly meaningful issue with potentially life-changing consequences, and its incidence has been growing worldwide. Assisted reproductive technology (ART) has made giant strides in terms of treating many infertility conditions, despite the risk of developing ovarian hyperstimulation syndrome (OHSS), a potentially life-threatening complication. Methods: This narrative review draws upon scientific articles found in the PubMed database. The search spanned the 1990–2024 period. Search strings used included “OHSS” or “ovarian hyperstimulation” and “IVF” and “GnRH” and “hCG”; 1098 results were retrieved and were ultimately narrowed down to 111 suitable sources, i.e., relevant articles dealing with the condition’s underlying dynamics, management pathways, and evidence-based criteria and guidelines, crucial both from a clinical perspective and from the standpoint of medicolegal tenability. Results: The following features constitute OHSS risk factors: young age, low body weight, and polycystic ovarian syndrome (PCOS), among others. GnRH antagonist can substantially lower the risk of severe OHSS, compared to the long protocol with a gonadotropin-releasing hormone (GnRH) agonist. However, a mild or moderate form of OHSS is also possible if the antagonist protocol is used, especially when hCG is used for the final maturation of oocytes. For women at risk of OHSS, GnRH agonist trigger and the freeze-all strategy is advisable. OHSS is one of the most frequent complications, with a 30% rate in IVF cycles. Conclusion: Providing effective care for OHSS patients begins with early diagnosis, while also evaluating for comorbidities and complications. In addition to that, we should pay more attention to the psychological component of this complication and of infertility as a whole. Compliance with guidelines and evidence-based best practices is essential for medicolegal tenability.
Kinases Inhibitors as New Therapeutic Opportunities in Cutaneous T-Cell Lymphoma
Authors: Valero-Diaz Sara , Amato Camilla , Casar Berta
Published: August 2024

Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of T-cell lymphomas characterised by high relapse rates and no curative treatments unless the allogeneic stem cell transplantation. The main complication in the management of this kind of malignancy is the variability that characterises the genetic and clinical features among the CTCL subtypes. JAK/STAT, MAPK/ERK, PI3K/Akt, and NF-kB are those signalling pathways that are found altered in CTCL and that are responsible for promoting both T-cell malignancy and the pro-tumorigenic microenvironment. Thus, targeting key players of these pathways can be an advantageous therapeutic option for CTCL. In this review, we aim to summarise the different approaches that precisely inhibit the kinases of each cited signalling. JAK inhibitors seem to be the most promising kinase inhibitors for CTCL. However, adverse events have been reported especially in patients with immunosuppression or an underlying autoimmune disease. More studies are needed, especially clinical trials, to investigate the benefits of these drugs for the treatment of cutaneous T-cell lymphomas.
Urban and Rural Environments and Their Implications for Older Adults’ Adaptation to Heat Waves: A Systematic Review
Authors: De Gea Grela Pablo , Sánchez-González Diego , Gallardo Peralta Lorena Patricia
Published: August 2024

The aim of this study is to synthesise the scientific evidence on the implications of urban and rural environments on older adults’ adaptation strategies to heatwaves. Methods: The methodology follows PRISMA guidelines, which involves a systematic search of the scientific literature in selected electronic databases, including Web of Science and Scopus, to assist in the selection, identification and retention of studies. Results: The search identified 4991 potentially eligible articles, of which 17 met the criteria, mainly from developed countries, emphasising a multidisciplinary approach and moderate to low quality. Urban and rural environments influence older adults’ adaptation strategies to heatwaves through the adequacy of the physical environment of the dwelling (design, materials, equipment) and the neighbourhood (green spaces, residential density, land use), the social environment (support network and type of assistance) and risk management (protective measures and heat warning systems). At the individual level, adaptation to heatwaves is determined by age, gender, health status, socio-economic status and social isolation. Discussion and conclusions: Differences in perceptions of heat adaptation were found according to location, typology and environmental characteristics, especially in developing countries. The findings contribute to promoting the adoption of protective measures, the design of heat warning systems, and the planning of friendly and resilient cities and rural communities to support the adaptation of an ageing society to the climate warming.
Urban Regeneration through Cultural–Tourism Entrepreneurship Based on Albergo Diffuso Development: The Venac Historic Core in Sombor, Serbia
Authors: Antonić Branislav , Stupar Aleksandra , Kovač Vladimir , Sovilj Danira , Grujičić Aleksandar
Published: August 2024

The inner core of Sombor, known as “Venac”, is probably the best-preserved one among medium-sized cities in Serbia. The stagnation of Sombor during the 20th century and its urban shrinkage in the 21st century have prevented significant transformations of the core, enabling its preservation under state protection as an urban heritage site. However, the recent rise of cultural tourism has triggered urban regeneration. As the city is still unprepared for this change, this regeneration has mostly omitted the inner core. Realising this, local representatives and experts have started rethinking innovative approaches to its regeneration, including the concept of Albergo Diffuso. This sustainable concept is created to revive the historic cores of small, shrinking cities and towns. Basically, it represents a hotel situated in several old buildings dispersed throughout a historic urban fabric, fitting perfectly into the regeneration of Venac. However, the current lack of precise spatial indicators and thresholds makes their incorporation into the planning process challenging. Considering this, this study focuses on the current spatial development of tourism in Venac, analysing the elements that would support and facilitate the application of this concept in the future. This article also proposes a set of new planning measures to support a strategically organised approach—from the emphasis on urban reuse and physical renewal to multileveled linking of basic concept conditions to the prioritization of pedestrian-friendly places and the application of innovative urban design in open public spaces. By connecting the selected Albergo Diffuso approach with spatial development and its analysis, this study also contributes to the spatial imprint of the concept’s implementation.
Identifying Legal, BIM Data and Visualization Requirements to Form Legal Spaces and Developing a Web-Based 3D Cadastre Prototype: A Case Study of Condominium Building
Authors: Ilgar Azer , Kara Abdullah , Çağdaş Volkan
Published: August 2024

Over the past decade, numerous countries and researchers have been investigating the potential of 3D cadastre based on the Building Information Model (BIM). In Türkiye, the General Directorate of Land Registry and Cadastre (GDLRC) has been engaged in the “Production of 3D City Models and Creation of 3D Cadastral Bases Project” since 2018. One of the objectives is to develop 3D (physical) digital building models (and databases) through the digitization of floor plans of architectural drawings. In order to ensure the long-term viability of this project, a new regulation was issued in 2021. This regulation mandates the submission of 3D digital building models to the land registry in order to register condominiums. The future goals of the GDLRC include utilizing the 3D digital building models produced to create legal spaces in condominium buildings for the 3D cadastre. However, no research has yet been carried out for this goal. The objective of this research is to identify the legal and BIM data requirements for deriving legal spaces in condominium buildings, in light of the legislative analysis, and to develop a web-based 3D cadastre visualization prototype (showing both legal spaces and physical objects) based on the requirements obtained from the scientific literature. The result of this research demonstrates that well-structured and annotated BIM data can be used to develop a 3D cadastre prototype that meets the legal requirements in the case of Türkiye. Moreover, it is evident that, although the GDLRC has initiated the construction of a robust foundation for a 3D cadastre based on BIM, further enhancements and resolutions must be implemented from a legal and technical standpoint. It is postulated that the identified requirements and the proposed methodology in this research may assist decision-makers in Türkiye and globally in formulating their strategic plans for a 3D cadastre.
Shoreline Translocation during Road Expansion Was Successful for Most Waterbirds but Not for Waders
Authors: Husby Magne
Published: August 2024

Coastal wetlands are one of the most threatened ecosystems due to, firstly, their relative rarity and, secondly, the strong human interest in these coastal sites for infrastructure development, and recreation. These coastal wetlands also serve as important migration stopover sites for a range of waterbirds. There is great international interest in mitigating the negative effects of human land development and in restoring degraded habitats. I evaluated the response of one waterbird community to the mitigation action implemented during road expansion in an important waterbird coastal habitat in central Norway. Using a novel mitigation method, the shoreline was moved seawards to allow space for a continued shoreline habitat and the extended road. By weekly monitoring the waterbird community during spring and autumn migration periods (n = 7 of each), I found similar biodiversity, evenness, and abundance of geese, dabbling ducks, diving ducks, gulls, and waders when data for the whole wetland were used. However, after construction waders were partially displaced from the zone closest to the road to a zone further away. For some groups of birds, shoreline translocation can be a fruitful mitigation action aiming to reduce the negative effects of infrastructure expansion in coastal areas.
Assessing the Role of Input Factors in Harmonious Bilingual Development in Children
Authors: Tiulkova Ekaterina , Marijanović Vanda , Camps Jean-François , Köpke Barbara
Published: August 2024

This study delves into the concept of Harmonious Bilingual Development (HBD), characterizing families where linguistic situations do not adversely affect their well-being. Following a recently proposed holistic framework on Harmonious Bilingual Experience (HBE), this research aims to discern the relationship between input factors and the bilingual children’s social–emotional and behavioral skills (SEBS). While input undoubtedly plays a major role in bilingual development, more insight is needed on the quantity and quality of input necessary to foster HBD. A total of 36 five-year-old children with Russian and French as their first languages participated in our study. Children’s language exposure and input quality, as well as parental attitudes, beliefs and strategies regarding language transmission, were assessed with parent questionnaires and activity journals. Additionally, parents assessed their children’s SEBS using the Strengths and Difficulties Questionnaire. Hierarchical cluster analysis identified family profiles which support HBD. We found that the quantity of Russian input, as measured by current exposure, does not directly correlate with SEBS. However, less than 30% of weekly input in Russian appears insufficient for achieving HBD. Furthermore, our study suggests that engaging in at least one extra-curricular activity in Russian, e.g., Saturday school, coupled with parental impact belief, aligns with a family profile experiencing more HBD. These results are coherent with previous studies on harmonious bilingualism, and emphasize the interplay of quantitative and qualitative input factors, as well as SEBS, for achieving HBD.
The Etiological and Antimicrobial Susceptibility Profiles of the Bacteria Obtained from Ovine Caseous Lymphadenitis Cases in the Çankırı Region, Türkiye
Authors: Tarhane Serdal , Büyük Fatih
Published: August 2024

Sheep caseous lymphadenitis (CLA) causes significant economic losses in the livestock sector by causing a loss in the quantity and quality of animal products and a loss in the breeding value of animals. Although the primary agent in CLA’s etiology is Corynebacterium pseudotuberculosis, some other opportunistic microorganisms also play a role. Therefore, the control and treatment of CLA necessitates the identification of the relevant etiological agents. This study aimed to conduct an in vitro culture and molecular characterization (PCR analysis and 16S rRNA sequencing) of the bacteria involved in sheep CLA cases reported in the Çankırı province of Türkiye and determine the antibiotic susceptibility of the case isolates. In total, 82 (16.4%) of 500 sheep in five farms were diagnosed with CLA. Following the culture of the superficial abscesses samples, C. pseudotuberculosis was identified in 30 (36.59%) as a result of PCR, Pseudomonas spp. in 8 (9.76%), and Enterobacter cancerogenus in 1 (1.22%), as a result of 16S rRNA sequencing. These data revealed extensive heterogeneity among the Pseudomonas isolates, with hints of derivation from a common ancestry for some and phylogenetic similarity to isolates from Germany, Malaysia, and India. In contrast to the high susceptibility to cefoperazone and lincomycin, the high resistances of C. pseudotuberculosis and Pseudomonas spp. isolates to cephalothin, ceftiofur, cloxacillin, amoxicillin, and bacitracin were remarkable. Based on these findings, it was concluded that for an effective treatment and control of ovine CLA cases, there is a need to consider the possible involvement of opportunistic bacteria other than the primary causative agent, C. pseudotuberculosis. It also contributed to increasing the country-specific sequence data and establishing new taxa from a universal perspective.
Synthesis of Diastereomeric 2,6-bis{[3-(2-Hydroxy-5-substitutedbenzyl)octahydro-1H-benzimidazol-1-yl]methyl}-4-substituted Phenols (R = Me, OMe) by Mannich-Type Tandem Reactions
Authors: Quiroga Diego , Ríos-Motta Jaime , Rivera Augusto
Published: August 2024

The synthesis and characterization of two novel diastereomeric Mannich bases was carried out from the reaction of the cyclic aminal (2R,7R,11S,16S)-1,8,10,17-tetraazapentacyclo[8.8.1.1.8,170.2,70.11,16]icosane 1 and p-cresol 2a and 4-methoxyphenol 2b in a water/dioxane mixture. The title compounds (4a–b) are interesting because bearing two 3-(2-hydroxy-5-substitutedbenzyl)octahydro-1H-benzimidazol-1-yl]methyl} substituents joined to an arenol ring. The formation of these new Mannich bases in the reaction mixture can be explained by aminomethylation of previously reported di-Mannich base 2,2′-((hexahydro-1H-benzo[d]imidazole-1,3(2H)-diyl)bis(methylene))bis(4-substituentphenol) 3a–b. NMR analysis demonstrated that compounds 4a–b were formed as diastereomeric mixtures. Subsequent experiments revealed that at longer reaction times, the percentage yield of these new products increased considerably (yield percentages up to 22–27%), suggesting a nucleophilic competition between the p-substituted phenols and Mannich bases of type 3 for aminal 1.
Nanocrystalline Cellulose to Reduce Superplasticizer Demand in 3D Printing of Cementitious Materials
Authors: Jarabo Rocío , Fuente Elena , García Calvo José Luis , Carballosa Pedro , Negro Carlos
Published: August 2024

One challenge for 3D printing is that the mortar must flow easily through the printer nozzle, and after printing, it must develop compressive strength fast and high enough to support the layers on it. This requires an exact and difficult control of the superplasticizer (SP) dosing. Nanocrystalline cellulose (CNC) has gained significant interest as a rheological modifier of mortar by interacting with the various cement components. This research studied the potential of nanocrystalline cellulose (CNC) as a mortar aid for 3D printing and its interactions with SPs. Interactions of a CNC and SP with cement suspensions were investigated by means of monitoring the effect on cement dispersion (by monitoring the particle chord length distributions in real time) and their impact on mortar mechanical properties. Although cement dispersion was increased by both CNC and SP, only CNC prevented cement agglomeration when shearing was reduced. Furthermore, combining SP and CNC led to faster development of compressive strength and increased compressive strength up to 30% compared to mortar that had undergone a one-day curing process.
Development of Robust PEBAX-Based Angiographic Catheter: Design and In Vitro Study
Authors: Inam Hafsa , Ali Murtaza Najabat , Jameel Ibraheem Raza , Awaiz Dil , Qureshi Zunaira
Published: August 2024

Background: Keeping in mind the unceasingly escalating prevalence of coronary disease worldwide, the mortality rate is also expected to rise with a staggering increase in healthcare costs. Angiography is the gold standard for diagnosing these blockages that trigger these diseases. Amides and urethanes are the common catheter construction material used for angiography. However, the experimental evidence verifying the use of PEBAX® and comparing its performance with that of commercially available catheters for angiography is not published despite it being well recognized for its excellent flexural modulus, mechanical properties, and biocompatibility and its potential to reduce the incidence of vascular spasm during intravascular diagnostic and interventional procedures. Therefore, the aim of this study was to develop a PEBAX®-based angiographic catheter and evaluate its performance in comparison with three commercially available nylon- and polyurethane-based angiographic catheters. Methodology: A PEBAX®-based angiographic catheter was developed for this purpose. This study analyzes and reports the performance and behavior of PEBAX®-, nylon-, and polyurethane-based catheters. The catheter’s performance and arterial forces’ endurance nature were mapped out by evaluating pushability (advancement force) and selective bench tests outlined in the applicable regulatory standard. Conclusions: The PEBAX®-based catheter exhibited the least bond-flexural rigidity (180.4 g), which was approximately one-third of that shown by all six French catheters and which exhibited the least advancement force (510.4 g), which was approximately 50% less than that of the nylon- and polyurethane-based catheters when traversing through the mock arterial system. Bench testing was carried out as per the applicable regulatory standard; the differences obtained between individual catheters were discussed in detail. Based on this extensive in vitro assessment, it was concluded that the PEBAX®-based catheters outperformed the nylon- and polyurethane-based catheters, exhibiting an exceptionally minimal advancement force of 510.4 g. This leads to the inference that this catheter can inject more radiopaque material (because of the enhanced flow rate) to the coronary arteries and can play a significant role in minimizing vascular spasms during a diagnostic procedure.