bluuebunny/crossref_metadata_2025 huggingface dataset:
SEMELHANÇA ENTRE TABAGISTAS E INFECTADOS POR COVID-19
Authors: Pereira Lyon José da Costa , Rodrigues Mateus Felipe , Silva Victor Oliveira , Bacelar Júnior Arilton Januário
Published: December 2021

O agravamento dos quadros pulmonares tanto em tabagistas quanto em pacientes com comorbidades respiratórias tais como infecção por Covid-19, em ambos possuem semelhanças incluindo receptores, enzimas e sintomas. No entanto os fumantes possuem quadros mais agravantes devido as doenças que o tabaco já induz a saúde do indivíduo além de terem um maior risco ao se infectarem pelo vírus SARS-CoV-2 em relação aos não fumantes. Várias instituições de pesquisas relacionam o tabaco(relacionando todos os tipos) como fator agravante a infecção pelo novo coronavírus. A nicotina, uma das principais substâncias presente no cigarro, é estudado como fator de proteção ao vírus. Está relacionado também os fumantes passivos, ou seja, aqueles que são ex-fumantes ou até mesmo aqueles que nunca fumaram, podem ter fatores agravantes.
RESPOSTA TERAPÊUTICA DA ALOPÉCIA ANDROGENÉTICA APÓS DRUG DELIVERY DIGITAL COM APLICAÇÃO DE PRODEW 500®, NANOFACTOR® AFGF, NANOFACTOR® VEGF, COPPER PEPTÍDEO®, PROHAIRIN B4®, CAPILLISIL HC® E ARCT-ALG®
Authors: Freitas Mônica Ramos de , Vasconcelos Rossana Cantanhede Farias de , Oliveira Filho Jayme de
Published: December 2021

A alopécia androgenética é caracterizada pela perda progressiva de folículos capilares, sendo causada pela interação de fatores endócrinos, predisposição genética e uma série de distúrbios bioquímicos. Considerando sua característica progressiva e seus múltiplos fatores relacionados, várias abordagens têm sido empregadas na tentativa de reverter o processo. Portanto, este trabalho avalia a resposta terapêutica da alopécia androgenética após drug delivery digital com aplicação tópica de Prodew 500®, Nanofactor® aFGF, Nanofactor® VEGF, Copper Peptídeo®, Prohairin B4®, Capillisil HC® e Arct-Alg®.
PAPEL DO FARMACÊUTICO DURANTE A PANDEMIA DA COVID-19
Authors: Pinto Fabiana dos Santos , Polkowski Guilherme Corrêa , Lima Israel Rocha , Chaves Anny Carolinny Tigre Almeida
Published: December 2021

A Organização Mundial da Saúde (OMS) decretou uma crise mundial na saúde pública e privada, mediante o surto do vírus SAR-CoV2. Sendo assim, a propagação do vírus inicialmente ocorreu na China, na província de Hubei, com 58,5 milhões de habitantes, e espalhou-se para os outros países (OMS, 2020). Ante exposto, o farmacêutico possui uma habilidade de identificação de possíveis problemas, que podem ser solucionados em estudos mais específicos na área da saúde de uma população. Dentre a problemáticas, uma das temáticas recorrentes, a automedicação, definida enquanto uma  perspectiva de autocuidado, porém, quando o uso é exagerado, há um ato prejudicial, podendo ter consequências, como efeito indesejado, enfermidades e o mascaramento de doença evolutiva. Sendo assim, o trabalho teve como objetivo apresentar o papel do farmacêutico perante a pandemia da  Covid-19, demonstrando a sua importância diante da descoberta de tratamentos eficazes para a patologia em questão e da atenção farmacêutica perante os mais diversos problemas relacionados a medicamentos  e as possíveis prevenções que tenham sido publicados na literatura no contexto da pandemia da Covid-19.
O ATENDIMENTO AOS ALUNOS COM DEFICIÊNCIA NA ESCOLA MUNICIPAL CÍVICO MILITAR PROFESSOR VERÍSSIMO DE MELO (ECIM): O QUE DIZ A LEI E COMO DE FATO ACONTECE NO COTIDIANO DA ESCOLA
Authors: Damasceno Neto Afonso Ribeiro , Paiva Figueira Águida Dionízio Benevides de , Silva Cristiano Araújo da , Silva Geilza de Lima Abdias da , Silveira Jadna Tavares da , Ferreira Josefa Poliana Clementino
Published: December 2021

Este artigo propõe-se a versar sobre os desafios enfrentados para a implantação da edu­cação especial dentro da atual política de educação inclusiva, sobretudo no Brasil. Para tanto, apresentamos um breve histórico das diversas etapas e movimentos a respeito das diretrizes educacionais baseadas na segregação dos alunos com deficiência, que sustentaram a educação especial  desde sua implantação até a adoção de uma política de matrículas na rede regular de ensino, dessa forma propõe a junção das crianças com ou sem deficiências em salas de aulas comuns das escolas públicas. Discutimos as condições de implantação da proposta do Governo Fe­deral de um “sistema educacional inclusivo”, que conta com um suporte de atendimento educacional especializado para complementar e suplementar a educação escolar. Outro ponto importante desse artigo é a discussão sobre a adequação do projeto político pedagógico para tornar a escola um espaço para todos, possibilitando que os alunos construam o conhecimento segundo suas capacidades e se desenvolvam como cidadãos nas suas diferenças, esse processo passa pela reestruturação física e pedagógica da escola, a adequação do currículo que garanta que o aluno de fato se sinta acolhido e incluindo, isso precisa ir além de sua socialização. Por fim apresentamos como se deu a implantação da sala e recursos multifuncional conjuntamente com o ensino educacional especializado na escola Municipal Cívico Militar professor Veríssimo de Melo, localizada na zona oeste da cidade de Natal/RN, visando acolher os alunos com deficiência com mais eficácia. Concluímos confirmando a importância dessas politicas públicas para os alunos com deficiência, porém ressaltando que ainda temos um grande caminho a percorrer para que de fato elas se desenvolvam conforme os parecerem que a regem.
DESAFIOS DA DOCÊNCIA NO CONTEXTO PANDÊMICO
Authors: Santos Rayane Leite dos , Lucas André do Carmo , Santos Juciê Leite dos
Published: December 2021

A necessidade da adoção do ensino remoto emergencial para garantir a continuidade das atividades letivas levou os docentes, os alunos e suas famílias a enfrentarem muitos novos desafios. Dessarte, esta pesquisa objetivou apresentar e discutir de forma geral os novos desafios dos docentes no cenário pandêmico e suas implicações na educação, e de forma mais específica analisar como se deu esse processo em uma escola da rede estadual do Maranhão, no munícipio de São Luís.  As principais dificuldades apontadas pelas professoras no ensino remoto estavam relacionadas principalmente a falta de capacitação para atuar nessa modalidade de ensino, sobrecarga de trabalho e problemas no aprendizado dos alunos, pois estes também não estavam aptos a usar as novas ferramentas de estudo e muitos estavam desmotivados.  Quanto a oferta de recursos tecnológicos para o ensino remoto, foram distribuídos chips para acesso à internet pelo governo do estado para todos os alunos e professores da rede, o que facilitou o acesso a aulas remotas. E neste novo cenário os docentes tiveram que desenvolver novas estratégias para a sua prática docente, sendo que as principais dificuldades ouvidas em relação aos alunos foram relacionadas a problemas para acessar internet, falta de celular ou computador, bem como a falta da interação com colegas e professores do ensino presencial. Constatou-se que várias questões foram postas em discussão, como o emprego de tecnologias como aliadas do ensino escolar, as desigualdades de acesso as tecnologias digitais, a importância e valorização do docente e da participação das famílias no processo letivo.
ALTERAÇÕES CARDÍACAS NA INFECÇÃO POR COVID-19
Authors: Oliveira Andresa Moura de , Santos Bárbara Giovana Rodrigues dos , Gomes Kethellen Jade dos Reis Martins , Rocha Letícia Ketelly Soares da , Arruda Victoria Maria Alves , Freitas Lorran Miranda Andrade de
Published: December 2021

Um novo patógeno se alastrou em Wuhan na China em dezembro de 2019, causando sintomas similares à pneumonia, sendo identificado posteriormente como SARS-CoV-2, causador da doença COVID-19. Logo em seguida, a Organização Mundial da Saúde (OMS) o declarou como uma doença de emergência internacional de alto risco, uma pandemia. Dentre as diversas complicações causadas pela COVID-19, as cardíacas são pouco mencionadas, entretanto representam um grande risco aos infectados, com destaque a indivíduos idosos e com comorbidades cardíacas. Assim, o estudo sobre as consequências da COVID-19 nas complicações cardíacas, com ênfase nas alterações dos exames laboratoriais pode auxiliar no diagnóstico e tratamento de lesões cardiovasculares decorridas pelo SARS-CoV-2, melhorando o prognóstico do paciente. Foram utilizados artigos disponíveis na literatura online como base para construção do artigo, sendo observados os dados, a literatura relata que pelo menos 8% dos pacientes diagnosticados com COVID-19 desenvolveu uma lesão cardíaca aguda, aumentando o risco de morte em duas vezes. Através da utilização de biomarcadores como a troponina ultrassensível e Dímero-D, que apresentam elevação em pacientes COVID-19 com lesão cardiovascular, o diagnóstico precoce do desenvolvimento de lesões pode ser obtido, aumentando as chances de sobrevivência e melhorando o prognóstico do paciente.
AVALIAÇÃO DA PERCEPÇÃO DA INCIDÊNCIA DE AGROTÓXICOS E SEUS POSSÍVEIS DANOS GENÉTICOS
Authors: Souza Lorhayne Cristina Barbosa de , Calili Luana Cristina Chaves , Araújo Jeannelly Mara Perreira , Tosate Tais da Silva , Sabino Hayane Ramos , Menezes Douglas Santiago , Reis Mikaely Botelho dos , Marcos Vilnara Domingos , Resende Nathane Silva , Bacelar Júnior Arilton Januário
Published: December 2021

No Brasil tem-se um dos maiores índices de ingestão residual de agrotóxicos do mundo, em virtude principalmente do seu uso em grandes quantidades em produtos de origem vegetal.  Diante disso, o fato tem se tornado uma preocupação constante e foco de diversos estudos sobre seus efeitos na saúde dos indivíduos a curto, médio e longo prazo. O presente estudo tem como objetivo discorrer os efeitos dos agrotóxicos sobre o organismo, dando ênfase na sua caraterística genotóxica, utilizando informações da literatura para descrever os efeitos adversos causados à saúde humana, diversos estudos associam o aparecimento de danos genéticos ao consumo de agrotóxicos, bem como o aparecimento de doenças não crônicas, como problemas neurológicos, dificuldade respiratória, irritação de pele, manifestações gastrointestinais, alterações no sistema reprodutor masculino e feminino, além de cânceres no cérebro, mama, esôfago, na pele, sistema digestivo e de reprodução. O estudo reforça a necessidade de mais pesquisas sobre o tema, com o intuito de elucidar de forma clara os reais danos à saúde, principalmente no que diz respeito ao aspecto genético. A dificuldade de associar o aparecimento dessa mutação à somente um agente ativo parece ser o principal empecilho para o progresso nos estudos, além disso, os estudos devem levar em consideração o aspecto acumulativo dessas substâncias no organismo humano.
PEMEDIASIAN PERSEPSI MANFAAT PADA KUALITAS KONTEN DAN DESAIN LEARNING MANAGEMENT SYSTEM TERHADAP INTENSI BELAJAR BERKELANJUTAN
Authors: Sienatra Krismi , Romauli Nainggolan  , Deandra Vidyanata  , Yuli Kartika Dewi  , I Gusti Bagus Yosia
Published: December 2021

Pandemi covid-19 menyebabkan pembelajaran dilakukan secara daring dengan konsep e-learning. Penyelenggara pembelajaran daring harus mendesain konten pembelajaran mereka pada learning management system (LMS) berbasis cloud. Penyusunan konten materi dan desain pembelajaran pada learning management system harus disusun dengan baik agar membuat pemakai merasakan manfaatnya dan akan terus melanjutkan menggunakan learning management system sebagai sarana pembelajaran. Panelitian ini bertujuan untuk melihat pengaruh dari kualitas desain dan kualitas konten dalam intensi belajar secara berkelanjutan dengan melihat persepsi kegunaan sebagai variabel mediasi. Sampel dalam penelitian ini adalah siswa yang menggunakan LMS untuk mangakses konten materi pembelajaran yang telah disusun secara utuh dan lengkap. Alat analisis data yang digunakan menggunakan partial least square (PLS). Hasil penelitian menunjukkan kualitas konten tidak berpengaruh terhadap intensi belajar dan kualitas desain berpengaruh terhadap intensi belajar dengan dimediasi oleh persepsi kegunaan.
ANALISIS SUMBER DAN PENGGUNAAN KAS DAN DAMPAKNYA TERHADAP LIKUIDITAS PADA PERUSAHAAN UMUM BULOG KANTOR CABANG MAUMERE PERIODE 2017-2019
Authors: Cicilia Ayu Wulandari Nuwa  , Rangga Yoseph darius purnama , Imanuel Wellem  , Kasilda Yuni Saputry
Published: December 2021

Penelitian ini bertujuan untuk mengetahui bagaimana sumber-sumber kas pada perusahaan umum bulog kantor cabang maumere, untuk mengetahui bagaimana Penggunaan Kas pada Perusahaan Umum Bulog Kantor Cabang Maumere, untuk mengetahui bagaimana tingkat Likuiditas perusahaan pada Perusahaan Umum Bulog Kantor Cabang Maumere, dan untuk mengetahui bagaimana Dampak Sumber dan Penggunaan Kas terhadap Likuiditas pada Perusahaan Umum Bulog Kantor Cabang Maumere. Berdasarkan hasil penelitian ini dampak yang ditemukan adalah apabila uang kas pada perusahaan umum bulog bertambah maka tingkat likuiditas akan ikut bertambah dan sebaliknya jika uang kas pada perusahaan umum bulog berkurang maka tingkat likuiditas akan ikut berkurang.
Evaluation of homeopathic medicine in rats subjected to a hypercaloric diet and stress
Authors: Wittmann Veronika , Arrifano VictÃ³ria , Pecorari Vanessa Gallego Arias , Viriato Ezequiel Paulo , Bonamin Leoni Villano , Bernardi Maria Martha , Coelho Cideli de Paula
Published: December 2021

Introduction: The factors related to obesity are complex, involving biologic, environmental and neuropsychological mechanisms[1-3]. Among the factors which influence the gain of weight, we can consider the stressful factors. Aims: The aim of this experiment was to evaluate the influence of the commercial homeopathic product compound by Fucus vesiculosus 1cH, Thyroidinum 5cH and Calcarea carbonica 5cH (BesomedÂ®) in the gain of weight in animals submitted to hypercaloric diet and stress. Materials and Methods 40 male freshly weaned Wistar rats, ingesting hypercaloric food, were divided into 4 groups, being two groups submitted to stress by standstill, being one group treated and the other one for control (vehicle) and two more groups without stress being one treated and the other one for control. All were given the drink water ad libidum, in blind, for 2 months. The general activity was evaluated by the Open Field method in 2 steps, one after stress and one after 1 month of treatment. The weekly gain of weight was measured during the whole period of treatment. The data were analyzed by the ANOVA method of two ways followed by the Bonferroni test[4], being pâ‰¤0,05. Results: The treatment with BesomedÂ® was effective in reducing only the gain of weight in the animals submitted to stress (pâ‰¤0,05); the evaluation of general activity in the Open Field showed increase in the time of freezing of these same animals after receiving the stressful stimulus. Discussion: The medicine is used as auxiliary in obesity treatment, and has the same both endogenous highdiluted molecules as the medicine used by similarity, which is the case of Calcarea carbonica, which, among others is indicated for obesity and hyperlipidemia[5], being observed in this study that the homeopathic complex group gained less weight than the other groups. Stress is capable of disturbing the physiological and psychological homeostasia of an individual, and when the stress is caused by standstill, it may induce behavior of the anxious type. There are also studies relating anxiety and feeding behavior in chronically stressed[6] individuals, showing that consuming a hypercaloric diet induces an anxious behavior[7] in male rats. In this study was not observed any change in the motor activity of animals which passed stress, however the time of freezing of the animals which took BesomedÂ® was the lowest (pâ‰¤0,05) after stress, if compared to the control groups, demonstrating the absence of an anxious behavior. Conclusion: The medicine evaluated was effective in reducing weight and in inducing an adaptive behavior only in the stressed animals, reducing the evaluated parameters to the same levels observed in the control group.
Measurement report: Observation-based formaldehyde production rates and their relation to OH reactivity around the Arabian Peninsula
Authors: Dienhart Dirk , Crowley John N. , Bourtsoukidis Efstratios , Edtbauer Achim , Eger Philipp G. , Ernle Lisa , Harder Hartwig , Hottmann Bettina , Martinez Monica , Parchatka Uwe , Paris Jean-Daniel , Pfannerstill Eva Y. , Rohloff Roland , Schuladen Jan , Stönner Christof , Tadic Ivan , Tauer Sebastian , Wang Nijing , Williams Jonathan , Lelieveld Jos , Fischer Horst
Published: December 2021

Abstract. Formaldehyde (HCHO) is the most abundant aldehyde in the troposphere. While its background mixing ratio is mostly determined by the oxidation
of methane, in many environments, especially in the boundary layer, HCHO can have a large variety of precursors, in particular biogenic and
anthropogenic volatile organic compounds (VOCs) and their oxidation products. Here we present shipborne observations of HCHO, hydroxyl radical (OH)
and OH reactivity (R(OH)), which were obtained during the Air Quality and Climate Change in the Arabian Basin (AQABA) campaign in summer 2017. The loss
rate of HCHO was inferred from its reaction with OH, measured photolysis rates and dry deposition. In photochemical steady state, the HCHO loss is
balanced by production via OH-initiated degradation of VOCs, photolysis of oxygenated VOCs (OVOCs) and the ozonolysis of alkenes. The slope
αeff from a scatter plot of the HCHO production rate versus the product of OH and R(OH)eff (excluding inorganic
contribution) yields the fraction of OH reactivity that contributes to HCHO production. Values of αeff varied between less than
2 % in relatively clean air over the Arabian Sea and the southern Red Sea and up to 32 % over the polluted Arabian Gulf (also known as
Persian Gulf), signifying that polluted areas harbor a larger variety of HCHO precursors. The separation of R(OH)eff into individual
compound classes revealed that elevated values of αeff coincided with increased contribution of alkanes and OVOCs, with the highest
reactivity of all VOCs over the Arabian Gulf.
SEGMENTASI CITRA SEBAGAI ALAT BANTU IDENTIFIKASI TANAMAN HUTAN
Authors: Sukariyan  , Franz Annafi , Suswanto
Published: December 2021

Indonesia merupakan salah satu negara di dunia yang memiliki kekayaan sumber daya. alam berlimbah baik didarat dan dilaut. Didarat negara Indonesia memiliki kekayaan flora dan fauna yang sangat banyak. Untuk flora jenis tanaman hutan di Indonesia terdapat berbagai jenis yang jumlahnya juga sangat banyak yang terdapat disetiap daratan Indonesia. Untuk belajar mengenal tanaman hutan yang merupakan tanaman hutan perlu belajar dengan bertanya pada ahlinya. Namun jika harus selalu bertanya pada ahlinya tentu akan menemui kendala karena seorang ahlipun tidak bisa untuk selalu ditanya setiap saat. Untuk itu perlu dibuat alat bantu yang mampu membantu untuk belajar mengenali tanaman hutan. Alat bantu ini berupa perangkat lunak yang mampu melakukan segmentasi citra tanaman hutan. Alat bantu ini dibuat sebagai media untuk belajar tentang tanaman hutan, karena alat bantu berupa perangkat lunak ini dibangun untuk identifikasi jenis tanaman hutan dengan mengenali polanya.
SISTEM INFORMASI GEOGRAFIS COFFEE SHOP DI KOTA SAMARINDA BERBASIS WEB
Authors: Khoeriyah Rofikhotul , Kurniadin Nia
Published: December 2021

Coffee Shop merupakan tempat yang banyak diminati oleh masyarakat Kota Samarinda. Terdapat beberapa perbedaan antara Coffee Shop dengan kedai kopi atau warung kopi, antara lain dari segi konsep, desain interior, sarana dan prasarana, menu dan segmen pasar. Akan tetapi masyarakat dihadapkan dengan permasalahan dalam mengetahui lokasi serta informasi yang ada pada Coffee Shop. Dengan demikian diperlukan sarana informasi yang dapat diakses oleh umum, salah satu cara dengan pembuatan peta informasi berbasis Web yaitu WebGIS. Tujuan dari kegiatan penelitian ini yaitu untuk memberikan informasi lokasi dan informasi lainnya tentang Coffee Shop yang ada di Samarinda, serta penyajiannya dalam bentuk peta informasi berbasis Web. Data yang dikumpulkan berupa nilai titik koordinat dari hasil pengamatan di lapangan, serta beberapa informasi mengenai Coffee Shop dari media sosial masing-masing Coffee Shop, yang kemudian diolah menggunakan perangkat lunak Quantum GIS menjadi peta informasi berbasis Web. Hasil penelitian menunjukkan bahwa terdapat 49 Coffee Shop yang tersebar di Kota Samarinda dan data tersebut disajikan dalam bentuk WebGIS yang disertai informasi yang ada pada masing-masing Coffee Shop tersebut.
IMPLEMENTASI PENGELOLAAN DAN PEMANTAUAN LINGKUNGAN HIDUP SEKITAR KEGIATAN KEHUTANAN
Authors: Hernandi M. Fikri , Rositah Erna , Wartomo  , Zarta Abdul Rasyid
Published: December 2021

Kualitas pelaporan belum sepenuhnya memenuhi Pedoman Kepmen LH Nomor 45/2005 terutama format laporan dan subtansi pelaporan.

Realisasi jenis dampak yang wajib dikelola dan dipantau kategori “baik”. Tingkat capaian implementasi kegiatan pengelolaan dan pemantauan dampak lingkungan pada kategori “cukup baik”

Implementasi pengelolaan dan pemantauan lingkungan belum optimal disebabkan oleh permasalahan koordinasi dan komitmen perusahaan, fokus kebijakan sektoral (PHPL dan Proper), jadwal dan kapasitas laboratorium, kapasitas pengetahuan dan kompetensi staf serta tidak ada umpan balik/koreksi. Penilaian pelaksanaan RKL-RPL oleh Instansi Lingkungan Hidup belum optimal disebabkan oleh permasalahan jumlah, kapasitas pengetahuan dan kompetensi staff.

Evaluasi terhadap beberapa dampak hasil pemantauan masih memenuhi ketentuan/standar ilmiah.  laju erosi kategori “Kelas III” atau “TBE sedang”. Kualitas air sungai sebesar 93,33% kategori “memenuhi BML” dan 6,67% kategori “telah melampaui BML”. Parameter air pada tingkat kritis “rendah” (68,89%). Indeks Pencemaran (IP) 66,67% tercemar “ringan” (IP 2,11–3,23) dan 33,33% kondisi “baik” (IP 0,29-0,84). Parameter air sungai yang tidak memenuhi BML meliputi timbal, DO, CaCO3, nitrit. Indeks keanekaragaman Shannon–Wiener vegetasi termasuk kriteria “tinggi”. Indeks keanekaragaman Shannon–Wiener fauna termasuk kriteria “sedang”. Indeks keanekaragaman Shannon-Wiener untuk plankton termasuk kriteria stabilitas komunitas biota sedang atau kualitas air tercemar sedang, sebaliknya untuk bentos termasuk kriteria stabilitas komunitas biota rendah atau kualitas air tercemar berat. Rekruitmen tenaga kerja lokal sebesar 90% atau meningkat 29,57% dari sebelum operasional.
PENGARUH JARAK TANAM DAN KONSENTRASI PUPUK CAIR SUPRATAN TERHADAP PERTUMBUHAN TANAMAN NILAM (Pogostemon cablin Benth)
Authors: Djadi Krisnanto , Larekeng Yuldanto , Setiawan Wawan
Published: December 2021

Tanaman nilam (Pogostemon cablin Benth) merupakan tanaman perkebunan penghasil minyak atsiri, dan memiliki fungsi utama sebagai bahan baku pengikat (fiksasif). Salah satu faktor yang mempengaruhi pertumbuhan tanaman nilam adalah kurangnya unsur hara dan jarak tanam saat penanaman. Penelitian ini bertujuan untuk mengetahui pengaruh jarak tanam dan pupuk cair supratan terhadap pertumbuhan tanaman nilam. Penelitian ini dilaksanakan pada bulan Mei sampai dengan September 2021 di Desa Kabua-Bua, Kecamatan Nuhon, Kabupaten Banggai. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) pola faktorial. Faktor pertama konsentrasi pupuk cair supratan (A) yang terdiri dari 3 taraf dan faktor kedua adalah jarak tanam (B) yang juga terdiri dari 3 taraf. Setiap kombinasi perlakuan diulang 3 kali sehingga seluruhnya terdapat 27 percobaan. Hasil penelitian menunjukkan bahwa perlakuan interaksi jarak tanam 5 mL pupuk Cair Supratan /Liter air +  Jarak tanam 40cm x 50cm (A3B1) merupakan perlakuan terbaik terhadap parameter jumlah tunas pada umur tanaman 6, 8 dan 10 MST dan perlakuan 5 mL pupuk Cair Supratan /Liter air (A3) merupakan perlakuan terbaik terhadap variabel jumlah tunas pada umur tanaman 12, 14, 16, 18, dan 20 MST. Pada pengamatan variabel jumlah daun, perlakuan interaksi jarak tanam 5 mL pupuk Cair Supratan /Liter air +  Jarak tanam 40cm x 60cm (A3B2) merupakan perlakuan terbaik pada umur tanaman 8 MST, dan perlakuan jarak tanam 40cm x 70cm (B3) merupakan perlakuan terbaik pada umur tanaman 10 dan 12 MST. Selain itu, perlakuan 5 mL pupuk Cair Supratan /Liter air (A3) merupakan perlakuan terbaik pada umur tanaman 16, 18 dan 20 MST
Historia y ruina en la obra de Walter Benjamin. De El origen del Trauers-piel alemán a las «Tesis de filosofía de la historia»
Authors: Martínez Matías Paloma
Published: December 2021

Este ensayo pretende mostrar la presencia en El origen del Trauerspiel alemán, escrito de habilitación de Walter Benjamin, de algunas de las ideas más relevantes que plantea en sus “Tesis de filosofía de la historia”. Para ello, se realiza en primer lugar una exposición de este último escrito de Benjamin centrada en su defensa de la necesidad de que el historiador materialista contemple la historia a partir de su propio presente, en la visión de la misma como catástrofe y ruina que Benjamin opone al historicismo y en el potencial revolucionario que subraya en esta comprensión del acontecer histórico. Posteriormente, se emprende un análisis de aquellos aspectos del escrito de habilitación de Benjamin que se dejan iluminar desde las “Tesis de filosofía de la historia”. Entre ellos, el significado que en él adquieren las nociones de constelación y mónada, que apunta a una interpretación del Barroco llevada a cabo desde la actualidad de Benjamin, y la percepción de la historia que atribuye a esta época, marcada igualmente, según se revela en su examen del Trauerspiel y de su recurso a la alegoría, por su carácter ruinoso y catastrófico.
El papel de las hipótesis en la filosofía natural de Isaac Newton
Authors: David Giraldo Jhoan Sebastian
Published: December 2021

El campo interpretativo sobre la obra de Newton ha sido ampliamente discutido y, particularmente, el tema de las hipótesis no ha sido la excepción. El objetivo de este texto es mostrar que la filosofía natural de Newton pareciera, en principio, rechazar la hipótesis, pero en realidad no es opuesta a la formulación de estas, si diferenciamos a qué tipo de hipótesis se hace referencia. Así pues, se muestra, en primer lugar, cómo desarrolla Newton su filosofía natural, y cómo es contrapuesta a las hipótesis. Luego se muestra que bajo condiciones determinadas las hipótesis son aceptadas. Y, por consiguiente, se concluye que la filosofía de Newton no rechaza radicalmente las hipótesis, sino que, por el contrario, se puede valer de su formulación para el progreso de la investigación científica, dependiendo a qué tipo de hipótesis se haga referencia.
The efficacy of the boric acid-based maintenance therapy in preventing recurrent vulvovaginal candidiasis
Authors: KALKAN Üzeyir , YASSA Murat , SANDAL Kemal , TEKİN Arzu Bilge , KILINÇ Ceyhun , GÜLÜMSER Çağrı , TUĞ Niyazi
Published: December 2021

Current gold-standard treatment of recurrent vulvovaginal candidiasis (RVVC) is mainly based on maintenance with fluconazole. Moderate to high recurrence rates at long-term use and secondary fluconazole resistance emerge as reasons to seek for new topical maintenance regimens. In this study, it is aimed to assess the efficacy and safety of boric acid-based treatment approach to treat clinical RVVC. In this retrospective study, patients who were diagnosed with RVVC received a treatment package for six months that consist of induction with boric acid vaginal suppositories 600 mg daily for 14 nights followed by maintenance for five nights starting with every fifth day of the menstrual cycles; a vaginal estriol-lactobacilli combination; and several rigorous life-style changes. The success was defined as the absence of symptomatic recurrence during the follow-up. Success rate at the first year was found to be 94.8% in a total of 173 patients. Mild, reversible side effects were observed in five patients (2.9%). Boric acid, along with a vaginal estriol-lactobacilli combination and lifestyle changes can be a safe and effective alternative in lieu of potent systemic antifungal drugs as a first-line treatment for the patients referred with RVVC.
Comparison of subacromial corticosteroid injection and physical therapy in patients with subacromial impingement syndrome: A prospective, randomized trial
Authors: DOĞAN Cengizhan , KETENCİ Sertaç , UZUNER Bora , ŞEN Halil Erdinç , BİLGİCİ Ayhan , ALAYLI Gamze , KURU Ömer
Published: December 2021

The aim of this randomized trial was to evaluate the efficacy of subacromial corticosteroid injection and physical therapy (PT) in patients with subacromial impingement syndrome (SIS). Forty patients who diagnosed as SIS were included in this study and were randomly assigned to the PT and injection groups. Pain during rest, sleep and motion were evaluated by visual analog scale (VAS). Disability was determined by Costant- Murley score. Physical and social functions were evaluated with Short Form-36 (SF-36). Active range of motion (ROM) was measured by goniometer. Patients were evaluated at baseline, 3rd and 8th weeks of the therapy. PT continued for 3 weeks with ultrasound and interferential current combined to local heat and exercise. For patients in the injection group, a single steroid injection of 40 mg triamcinolone acetonide into the subacromial space was combined with exercise. After eight weeks, significant improvements at pain, SF-36 and Costant-Murley scores were observed in both groups (p<0.001). Improvement rates of pain during sleep and motion were significantly higher in PT group than the injection group after 8 weeks (p<0.01). Significant improvements were determined at ROM in both groups (p<0.001). No statistically significant differences were found between two groups in terms of Costant-Murley and ROM scores. Results of the PT group were significantly better in terms of physical and social function, and pain subscores of SF-36 (p<0.05). Our results suggest that both PT and corticosteroid injection have beneficial effects on shoulder mobility and pain relief in SIS. PT should be an alternative and effective treatment method to corticosteroid injection in SIS.
Affecting factors on the publication rate of surgical theses from different departments in Turkey
Authors: GÜVEY Ali
Published: December 2021

The aim of the study is to investigate and compare the factors affecting publication rates of otorhinolaryngology (ORL) theses and plastic and reconstructive surgery (PRS) theses. In order to examine ORL and PRS specialization theses published between 2013 and 2017, the author scanned the Council of Higher Education Thesis Center’s browsing system that contains a list of all published theses for the terms “ear, nose, and throat” and “plastic and reconstructive surgery”. All accessible theses (in total, 689), including 454 ORL and 235 PRS theses were included in the study. Most ORL and PRS theses authors were male (72.5% and 84.3%, respectively). Most of the ORL theses were conducted in state universities (76.9%), whereas most of the PRS theses were conducted in public universities (87.2%). More than half (50.9%) of the ORL advisors were professor doctors, compared to 46.3% of the PRS advisors. Most of the ORL studies were clinical studies (81.7%), while 74.9% of the PRS studies were experimental animal studies. In total, 24.5% of the ORL theses were published, and 29.7% of them were accepted in SCI- indexed journals. In comparison, a total of 19.6% of the PRS theses were published. The publication rates of experimental PRS and ORL studies were significantly higher than clinical studies. In order to increase the quality of medical theses and to publish them in scientific journals, the frequency of thesis production should be increased and that the factors affecting publication rates should be carefully examined, monitored, and improved.
The role of triglyceride glucose index in predicting in-hospital adverse cardiovascular outcomes in patients with acute coronary syndrome
Authors: ÇETİN ŞANLIALP Sara , NAR Gökay
Published: December 2021

Previous studies have shown the association of triglyceride glucose (TyG) index with metabolic syndrome (MetS), cardiovascular disease (CVD) and long-term adverse cardiovascular outcomes. However, to best our knowledge, the relation between the TyG index and in-hospital adverse cardiovascular outcomes in acute coronary syndrome (ACS) has not yet been reported. Hence, in this study, we aimed to evaluate the role of the TyG index in predicting in-hospital adverse cardiovascular outcomes in ACS and to compare its performance with the Global Acute Coronary 3Department of XXX, University of XXX, XXX Training and Research Hospital, City, Country Events Register (GRACE) risk score. 170 patients diagnosed with ACS and underwent coronary angiography were analyzed retrospectively. The 4Department of XXX, Faculty of XXX, City, Country TyG index was calculated using the following formula: ln [fasting triglycerides (mg/dL)×fasting blood glucose (mg/dL)/2]. Receiver operating characteristics (ROC) curve analysis was used to evaluate the performance of the TyG index and GRACE risk score in predicting in-hospital adverse cardiovascular outcomes. A binary logistic regression model was applied to determine the independent predictors for in-hospital adverse cardiovascular outcomes. At the initial analysis, patients with adverse cardiovascular outcomes had higher TyG index and GRACE risk score (p=0.011, p<0.001). In ROC curve analysis, the GRACE score performed better in predicting in-hospital adverse cardiovascular outcomes compared to TyG index (AUC:0.716, p<0.001; AUC:0.588, p=0.054 respectively). In binary logistic regression analysis, left ventricular ejection fraction (LVEF), multi-vessel disease and GRACE risk score were independent predictors for in-hospital adverse cardiovascular outcomes (OR: 0.840, 95% CI: 0.791-0.891, p<0.001; OR: 3.581, 95% CI:1.382-9.282, p=0.009; OR= 1.017, 95% CI: 1.001-1.034, p=0.04 respectively). Our study findings revealed that the TyG index was scant in predicting in-hospital adverse cardiovascular outcomes compared to GRACE risk score. The independent predictors for in-hospital adverse cardiovascular outcomes were LVEF, multivessel disease and GRACE risk score.
Poplar-type propolis provides protection of blood cells, testosterone levels and sperm motility in cisplatin-induced toxicity
Authors: DEMİRTAŞ Abdullah , BAYDİLLİ Numan , SÖNMEZ Gökhan , DOĞANYİĞİT Züleyha , TEKİN Olgay Kaan , SİLİCİ Sibel
Published: December 2021

Cisplatin is a frequently used chemotherapeutic in many types of cancer, especially urological cancers. Despite its efficacy in the treatment of cancer, it causes various toxic side effects such as nephrotoxicity, neurotoxicity and ototoxicity. The aim of this study was to determine the protective role of olive oil extract of propolis (OEP) with biochemical and histopathological approaches to cisplatin induced toxicity. Sixty-four adult male Wistar rats were divided into eight groups, control, propolis (100 and 200 mg/kg, orally daily for 10 days) and combined therapy (propolis 10 days before and after CP injection). Haematological (Wbc, Rbc, Mpv, Hgb, Htc, Mcv, Mch, Mchc, Lym, Neu), biochemical (triglyceride, total cholesteol, HDL and LDL-cholesterol, glucose, BUN, uric acid and testosterone level), epididymal sperm concentration, sperm motility, and histological parameters were analyzed. According to the results, cisplatin has negative effects on hematological, biochemical parameters, and sperm motility compared to control group. Administration of pre-cisplatin propolis ameliorated wbc, hct, mcv, mchc, neu levels. The administration of OEP prior to CP normalized the increased BUN and uric acid levels induced by CP. Interestingly it was also revealed that the testosterone levels increased in the OEP groups compared to the control group. Additionally, the combined administration of CP with OEP normalized the decreased testosterone levels induced by CP, particularly pre-treatment OEP. As a result, propolis, a natural product with numerous useful biological effects, was shown to a have protective as well as amelioration and normalizing effect on CP-induced damage.
Investigating Adipokine levels in the sera of patients with myocardial infarction in a 6-month follow up
Authors: DOWLATSHAHI Ehsan , KHOSROPANAH Shahdad , KALANI Mehdi , DOROUDCHI Mehrnoosh
Published: December 2021

Adipokines are peptides that regulate endothelial function, inflammation, blood pressure, and hemostasis. We measured Leptin, Adiponectin, Resistin and Adipsin in a cohort of 36 STEMI patients. Serum levels of Adipokines were measured in three time-points by a multiplex assay. A significant difference in Adipsin concentration between day-5 (T5) and day-180 (T180) post-MI was observed. Resistin levels decreased significantly from day 0 (T0) to T5 and T180. Adiponectin/Resistin ratio increased from T0 to T180. Leptin at T0 and T5 were higher in non- smokers. Adipsin at T0 was inversely correlated with heart rate, respiratory rate and pulse rate. Adiponectin/Resistin ratio at T180 negatively correlated with respiratory-rate. Adiponectin/Resistin ratio at T180 was higher in patients with grade-1 atrioventricular (AV) block. Anteroseptal hypokinesia (AH) correlated with Resistin at T0 and Adipsin at T5 while Leptin at T0 and T5 correlated with AH. Adiponectin/Resistin ratio at T180 was; however, lower in patients with AH. A decreasing trend in Resistin and its T0 association with AH plus correlation of Leptin at T0 and T5 with AH show the effect of Adipokines on mechanical complications after MI. We suggest that Adipokine networks have both beneficial and harmful effects and may be new cardiac biomarkers and/or drug targets.
Headache can be the only symptom of COVID-19: A case series
Authors: ŞİMŞEK YURT Nur , YURT Yusuf Can , OCAK Metin
Published: December 2021

Headache is the fourth most common cause among the total applications to emergency services; it constitutes 5% of the applications to hospitals every year. Five-fold increase was detected in the incidence of headache in the regions affected by coronavirus disease-2019 (COVID-19) pandemic. While the symptoms of respiratory systems have been frequently observed, the occurrence of symptoms and complications in peripheral and central nervous system has become increasingly prevalent in the cases of COVID-19 disease. In this case series, we highlight that the patients with isolated headache may be diagnosed with COVID-19 infection. Three female patients (forty, sixty and sixty-two years of old) were admitted to the emergency service with complaints of severe headache. Their headache did not respond to the paracetamol and the nonsteroidal anti-inflammatory drug (NSAID) they used prior to their application to the hospital. No pathologic finding was detected in cerebral imaging. All patients were diagnosed with COVID-19 by their clinical status and history. The headache was the isolated symptom of the COVID-19 in all the three cases. The possibility of COVID-19 infection must be considered in the evaluation of the patients admitted to hospital with complaints of headache, one of the most frequent reasons for hospital assistance requests.
A case report of atypical Ramsay-Hunt Syndrome presented with severe vertigo and vomiting
Authors: KEF Kemal
Published: December 2021

Ramsay-Hunt Syndrome (Herpes zoster oticus) is often characterized by severe ear pain, vesicles on external auditory canal or auricula and peripheral facial paralysis. However, the patient in this case presented to the clinic with dizziness, pain in the ear and vomiting. During the physical examination there was no vesicles and no evidence of skin changes found around the auricula that were typical for Ramsay Hunt syndrome. The patient did not have facial paralysis. If there is an unexpected severe ear pain accompanying vertigo, Ramsay Hunt syndrome should be considered in the differential diagnosis even if there is no rash or facial paralysis.
Demirtaş Erciyes-Mid urethral fibrin fixation technique (DE-MUFFT) for female stress urinary incontinence: A case series
Authors: DEMİRTAŞ Türev , SÖNMEZ Gökhan , TOMBUL Şevket Tolga , DEMİRTAŞ Abdullah
Published: December 2021

Factors including suburethral blood flow impairment, collagen deficiency, and the lack of tissue healing factors are known to play a role in stress urinary incontinence (SUI). Autologous fibrin (AF) appears to be a viable material for the treatment of SUI. The aim of this study was to present the initial clinical outcomes of a novel technique named “Demirtaş Erciyes-Mid Urethral Fibrin Fixation Technique (DE-MUFFT)” that involved the placement of AF material in the suburethral space instead of sling material (mesh). In this study, the clinical outcomes of five women with pure SUI who underwent the placement of AF material in the suburethral space were examined retrospectively. The complaint of urine leakage during physical exertion and patients’ quality of life were assessed using Incontinence Quality of Life Scale (I-QoL), International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF), Incontinence Impact Questionnaire (IIQ-7), and 24-h pad test. Patient outcomes were evaluated preoperatively, at sixth week and third month postoperatively. Significant improvement was obtained in the quality-of-life tests and 24-h pad test. In all patients, the complaint of urine leakage disappeared almost completely. No adverse event or postoperative complication occurred in any of the patients. These results indicated that DE-MUFFT can be a promising procedure in the treatment of SUI due to its biocompatibility, minimally invasive nature, re-applicability, and cost-effectivity.
Analisis Perencanaan Sheet Pile pada Tanggul Sungai (Studi Kasus : Sungai Lungun, Sabanar Baru, Kabupaten Bulungan)
Authors: Hasrullah  , Elia Sebanya , Novianto Dandung
Published: December 2021

Penelitian ini dilakukan untuk mengidentifikasi penyebab longsor pada tanggul sungai. Penelitian ini bertujuan untuk mengetahui nilai faktor keamanan lereng serta merencanakan dimensional perkuatan sheet pile dan stabilitas di lereng Sungai Lungun. Pada proses analisis data, peneliti menggunakan Metode Fellenius untuk menganalisa stabilitas lereng eksisting, prinsip perancangan turap di angker yang terletak pada tanah kohesif dengan metode ujung bebas, dan juga dengan bantuan program teknologi komputer yaitu program aplikasi Plaxis.  Dari hasil analisis dan perhitungan, diperoleh kesimpulan bahwa nilai faktor keamanan pada lereng Sungai Lungun dengan menggunakan perhitungan manual Metode Fellenius diperoleh nilai sebesar 1,470 sedangkan hasil perhitungan dengan menggunakan program bantu Plaxis 2D V.8.2 didapatkan nilai factor keamanan sebesar 1,1092. Untuk solusi penanggulangan longsor lereng Sungai Lungun, ukuran dimensi perkuatan sheet pile yang diperoleh dari perhitungan yaitu menggunakan sheet pile beton tipe W-400 A 1000 dengan kedalaman 10 m ditambah dengan pengakuan angkur pada kedalaman 1 m dari permukaan tanah yang dikaitkan oleh tie rod baja Ø 7 cm sepanjang 14 m kepada blok angkur beton dengan tinggi blok angkur 1,5 m dan tebal 5 cm yang tertanam 0,5 m dari permukaan tanah, sehingga diperoleh nilai faktor keamanan yang dihitung dengan menggunakan program bantu Plaxis 2D V.8.2 sebesar 3,5814.
Analisis Quantity Take-Off Menggunakan BIM Pada Proyek Jalan Tol “X”
Authors: Travis Karina , Martina Nunung , Safri
Published: December 2021

Pada proyek konstruksi besar dan kompleks, BIM (Building Information Modelling) merupakan hal penting dalam globalisasi teknologi konstruksi. Melalui penerapan BIM diharapkan pada Proyek Jalan Tol “X” dapat meminimalisir kesalahan. Masalah yang terjadi dilapangan terdapat perhitungan QTO menggunakan AutoCAD dengan alat bantu Microsoft Excel dalam estimasi awal kurang akurat sehingga menghasilkan miss kalkulasi pada pelaksanaan, BIM diharapkan dapat menjadi solusi untuk masalah ini. Dilakukan studi kasus untuk mengetahui perbandingan quantity take-off pada konstruksi jalan tol pada Overpass Interchange “X” dan Jalan Akses menggunakan BIM dan konvensional. Data analisis diperoleh dari melakukan pekerjaan quantity take-off dengan berbasis BIM dan CAD Konvensional serta melakukan wawancara kepada pakar BIM. Berdasarkan penelitian yang dilakukan terdapat perbedaan perhitungan quantity take-off antara BIM dan manual menggunakan CAD konvensional, Persentase perbedaan perhitungan yang didapatkan yaitu pada pekerjaan tanah selisih 4,375%, galian struktur selisih 1,7%, perkerasan selisih 4,4%, struktur beton selisih  0,1%, dan pekerjaan lain-lain selisih 0%. BIM dapat mengefisienkan volume lebih aktual, namun membutuhkan waktu yang cukup lama untuk pemula dalam mendapatkan keakuratan. BIM dipengaruhi oleh tingkat ke-detailan pemodelan, jika pemodelan tidak dimodelkan dengan benar maka akan memberikan hasil perhitungan volume yang salah. Menggunakan BIM pada awal perencanaan sangat efektif dalam mencegah terjadinya re-desain serta desain yang tidak efisien dan miss kalkulasi.
Analisis Faktor Keterlambatan Pada Pembangunan Proyek X
Authors: Fahira Khairani  , Supriyadi Iwan
Published: December 2021

Dalam suatu proyek konstruksi biasanya memiliki jadwal dan kegiatan kerja tersendiri. Perencanaan proyek mengacu pada perkiraan yang telah dihasilkan pada saat pembuatan rencana. Jika terdapat perbedaan antara rencana yang telah direncanakan dengan pelaksanaannya, maka dapat menimbulkan keterlambatan pembangunan proyek. Berdasarkan kurva s, pada bulan Mei progres seharusnya sudah mencapai 83,8%, tetapi realisasi di lapangan baru mencapai 59,2%, maka dapat dilihat bahwa proyek memiliki indikator terlambat. Sehingga berdasarkan data persentase tersebut, perlu dilakukan kajian mengenai faktor dominan penyebab keterlambatan proyek. Tujuan dari penelitian ini ialah untuk mengungkapkan atau menemukan faktor dominan yang mempengaruhi keterlambatan  serta solusi atas keterlambatan pada pembangunan Proyek X. Pengumpulan data dilakukan dengan menyebarkan kuesioner kepada individu yang terlibat langsung dengan pembangunan proyek seperti kontraktor, konsultan pengawas, dan pemilik. Analisis regresi linier berganda digunakan untuk menganalisis data dengan memakai software SPSS V25. Faktor keuangan dengan parameter X28, yaitu keterlambatan pembayaran oleh pemilik memperoleh nilai β sebesar 0,386 terbukti menjadi faktor paling signifikan terhadap keterlambatan pembangunan Proyek X serta upaya untuk mengatasi keterlambatan tersebut ialah dengan memberikan surat kepada owner agar dibuatkan rencana cash in pelunasan outstanding pembayaran termin progres.
Pengaruh Penambahan Limbah Plastik Low Density Polyethylene Terhadap Karakteristik Campuran Laston AC-WC
Authors: Erni Dwi Susanti , Rifqi Mirza Ghulam , Amin M. Shofi'ul
Published: December 2021

Permasalahan sampah plastik saat ini telah menjadi salah satu konsentrasi dunia. Upaya pengurangan dan pencegahan telah banyak dilakukan, namun secara umum hasil yang didapat tidak sebanding dengan pertumbuhan penggunaan plastik yang terus meningkat khususnya plastik yang tidak terkelola dengan baik. Salah satu upaya yang dilakukan adalah pemanfaatan limbah plastik sebagai bahan tambah campuran beraspal panas Laston AC-WC yang disebut modifikasi. Tujuan penelitian ini adalah untuk mengetahui bagaimana pengaruh penambahan limbah plastik jenis Low Density Polyethylene (LDPE) terhadap karakteristik Marshall Laston AC-WC. Pengujian yang dilakukan antara lain pengujian agregat, pengujian aspal, pengujian plastik, dan pengujian Marshall. Perancangan campuran dilakukan dengan cara kering (dry process) menggunakan variasi kadar plastik sebesar 0%, 4,5%, 5%, dan 5,5% yang masing-masing memakai 5 kadar aspal yaitu 5%, 5,5%, 6%, 6,5%, dan 7% dengan masing-masing 3 benda uji, sehingga total ada 75 benda uji. Hasil uji Marshall diperoleh KAO sebesear 6,5% dengan variasi kadar plastik sebesar 5,5%, diperoleh stabilitas 2167,40 kg, Flow 3,8 mm, VIM 3,94%, VMA 15,95%, VFA/VFB 77,12%, dan MQ 570,37 kg/mm. Sehingga penambahan limbah plastik jenis LDPE memenuhi (Spesifikasi Umum Bina Marga, 2018).