bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1B from Individual Patient-Specific Immunity against High-Grade Glioma after Vaccination with Autologous Tumor Derived Peptides Bound to the 96 KD Chaperone Protein
Authors: Crane Courtney A. , Han Seunggu J. , Ahn Brian , Oehlke Jessica , Kivett Valerie , Fedoroff Anne , Butowski Nicholas , Chang Susan M. , Clarke Jennifer , Berger Mitchel S. , McDermott Michael W. , Prados Michael D. , Parsa Andrew T.
Published: April 2023

PDF file, 48K, Overall Survival Characteristics of Treated Patients.
Supplementary Table 1A from Individual Patient-Specific Immunity against High-Grade Glioma after Vaccination with Autologous Tumor Derived Peptides Bound to the 96 KD Chaperone Protein
Authors: Crane Courtney A. , Han Seunggu J. , Ahn Brian , Oehlke Jessica , Kivett Valerie , Fedoroff Anne , Butowski Nicholas , Chang Susan M. , Clarke Jennifer , Berger Mitchel S. , McDermott Michael W. , Prados Michael D. , Parsa Andrew T.
Published: April 2023

PDF file, 50K, Descriptive Characteristics of the Study Population.
Supplementary Figure 3 from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis
Authors: Tone Alicia A. , Virtanen Carl , Shaw Patricia , Brown Theodore J.
Published: April 2023

PDF file, 27K, DAB2 and BRCA1 enhance dexamethasone-induced GR transactivation activity in pancreatic and breast cancer cell lines.
Supplementary Figure 3 from Individual Patient-Specific Immunity against High-Grade Glioma after Vaccination with Autologous Tumor Derived Peptides Bound to the 96 KD Chaperone Protein
Authors: Crane Courtney A. , Han Seunggu J. , Ahn Brian , Oehlke Jessica , Kivett Valerie , Fedoroff Anne , Butowski Nicholas , Chang Susan M. , Clarke Jennifer , Berger Mitchel S. , McDermott Michael W. , Prados Michael D. , Parsa Andrew T.
Published: April 2023

PDF file, 8781K, Representative phenotypic analysis of circulating lymphocytes in a clinical non-responder (Patient #003).
Supplementary Figure 2 from Individual Patient-Specific Immunity against High-Grade Glioma after Vaccination with Autologous Tumor Derived Peptides Bound to the 96 KD Chaperone Protein
Authors: Crane Courtney A. , Han Seunggu J. , Ahn Brian , Oehlke Jessica , Kivett Valerie , Fedoroff Anne , Butowski Nicholas , Chang Susan M. , Clarke Jennifer , Berger Mitchel S. , McDermott Michael W. , Prados Michael D. , Parsa Andrew T.
Published: April 2023

PDF file, 9905K, Representative phenotypic analysis of circulating lymphocytes in a clinical responder (Patient #009).
Supplementary Figure 1 from Prolonged Postovulatory Proinflammatory Signaling in the Fallopian Tube Epithelium May Be Mediated through a BRCA1/DAB2 Axis
Authors: Tone Alicia A. , Virtanen Carl , Shaw Patricia , Brown Theodore J.
Published: April 2023

PDF file, 1402K, Differential expression of RelA and DAB2 proteins in secretory FTE cells.
Supplementary Table 1-2 from EGFR Exon 19 Insertions: A New Family of Sensitizing EGFR Mutations in Lung Adenocarcinoma
Authors: He Mai , Capelletti Marzia , Nafa Khedoudja , Yun Cai-Hong , Arcila Maria E. , Miller Vincent A. , Ginsberg Michelle S. , Zhao Binsheng , Kris Mark G. , Eck Michael J. , Jänne Pasi A. , Ladanyi Marc , Oxnard Geoffrey R.
Published: April 2023

PDF file - 79K
Supplementary Tables 1 - 3, Figures 1 - 8 from A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101
Authors: Baldwin R. Michael , Owzar Kouros , Zembutsu Hitoshi , Chhibber Aparna , Kubo Michiaki , Jiang Chen , Watson Dorothy , Eclov Rachel J. , Mefford Joel , McLeod Howard L. , Friedman Paula N. , Hudis Clifford A. , Winer Eric P. , Jorgenson Eric M. , Witte John S. , Shulman Lawrence N. , Nakamura Yusuke , Ratain Mark J. , Kroetz Deanna L.
Published: April 2023

PDF file, 288K, Supplemental data showing study design, quality control, and replication results.
Supplementary Figure Legend from In Vivo Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Trigger Vγ9Vδ2 T-cell Antitumor Cytotoxicity through ICAM-1 Engagement
Authors: Benzaïd Ismahène , Mönkkönen Hannu , Bonnelye Edith , Mönkkönen Jukka , Clézardin Philippe
Published: April 2023

PDF file - 95K
Data Supplement from Noninvasive Detection of Glutamate Predicts Survival in Pediatric Medulloblastoma
Authors: Wilson Martin , Gill Simrandip K. , MacPherson Lesley , English Martin , Arvanitis Theodoros N. , Peet Andrew C.
Published: April 2023

Supplementary Methods (Text 1). A description of the treatment protocols used during the study period. Supplementary Figure 1. Example medulloblastoma fits where the lowest smooth black line is the baseline; the middle black line represents the acquired spectrum following pre-processing; the red line shows the spectral fit and the top black line shows the residual between the fit and acquired spectrum. A) shows a distorted baseline leading to qc failure whereas B) is an example of an ideal smooth baseline.
Supplementary Table 1 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia
Authors: Lionetti Marta , Musto Pellegrino , Di Martino Maria Teresa , Fabris Sonia , Agnelli Luca , Todoerti Katia , Tuana Giacomo , Mosca Laura , Gallo Cantafio Maria E. , Grieco Vitina , Bianchino Gabriella , D'Auria Fiorella , Statuto Teodora , Mazzoccoli Carmela , De Luca Luciana , Petrucci Maria Teresa , Offidani Massimo , Di Raimondo Francesco , Falcone Antonietta , Caravita Tommaso , Omede' Paola , Morabito Fortunato , Tassone Pierfrancesco , Boccadoro Mario , Palumbo Antonio , Neri Antonino
Published: April 2023

PDF file - 22K, Results of correlation analysis between miRNA expression and copy number.
Supplementary Table 5 from Circulating miRNAs as Surrogate Markers for Circulating Tumor Cells and Prognostic Markers in Metastatic Breast Cancer
Authors: Madhavan Dharanija , Zucknick Manuela , Wallwiener Markus , Cuk Katarina , Modugno Caroline , Scharpff Martina , Schott Sarah , Heil Jörg , Turchinovich Andrey , Yang Rongxi , Benner Axel , Riethdorf Sabine , Trumpp Andreas , Sohn Christof , Pantel Klaus , Schneeweiss Andreas , Burwinkel Barbara
Published: April 2023

XLS file, 8K, Age adjusted analysis of miRNA for CTC-positive and CTC-negative comparison.
Supplementary Figure 5 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia
Authors: Lionetti Marta , Musto Pellegrino , Di Martino Maria Teresa , Fabris Sonia , Agnelli Luca , Todoerti Katia , Tuana Giacomo , Mosca Laura , Gallo Cantafio Maria E. , Grieco Vitina , Bianchino Gabriella , D'Auria Fiorella , Statuto Teodora , Mazzoccoli Carmela , De Luca Luciana , Petrucci Maria Teresa , Offidani Massimo , Di Raimondo Francesco , Falcone Antonietta , Caravita Tommaso , Omede' Paola , Morabito Fortunato , Tassone Pierfrancesco , Boccadoro Mario , Palumbo Antonio , Neri Antonino
Published: April 2023

PDF file - 29K, Multivariate analysis comparing each of the four miRNA-model (A: miR-22, B: miR-146a, C: miR-92a, D: miR-330-3p) with biological and molecular variables in pPCL series.
Supplementary Table 1 from The Effects of Chemotherapy on Cognitive Function in a Mouse Model: A Prospective Study
Authors: Winocur Gordon , Henkelman Mark , Wojtowicz J. Martin , Zhang Haibo , Binns Malcolm A. , Tannock Ian F.
Published: April 2023

PDF file, 59KB, Supplementary Table S1. The average weights of mice in the SAL and CHEMO groups that completed the entire experiment, at baseline and after follow-up testing. The table also shows the difference in weight between the beginning and end of the experiment for both groups. (CI = confidence interval)
Supplementary Table 2 from Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma: Intent-to-Treat Analysis and Efficacy after Failure to Prior Immunotherapies
Authors: Besser Michal J. , Shapira-Frommer Ronnie , Itzhaki Orit , Treves Avraham J. , Zippel Douglas B. , Levy Daphna , Kubi Adva , Shoshani Noa , Zikich Dragoslav , Ohayon Yaara , Ohayon Daniel , Shalmon Bruria , Markel Gal , Yerushalmi Ronit , Apter Sara , Ben-Nun Alon , Ben-Ami Eytan , Shimoni Avichai , Nagler Arnon , Schachter Jacob
Published: April 2023

PDF file - 74K, the baseline and treatment characteristics of evaluated TIL patients treated with or without ipilimumab before TIL ACT.
Supplementary Figure 1 from Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK–Positive Non–Small Cell Lung Cancer
Authors: Tanizaki Junko , Okamoto Isamu , Okabe Takafumi , Sakai Kazuko , Tanaka Kaoru , Hayashi Hidetoshi , Kaneda Hiroyasu , Takezawa Ken , Kuwata Kiyoko , Yamaguchi Haruka , Hatashita Erina , Nishio Kazuto , Nakagawa Kazuhiko
Published: April 2023

PDF file, 80K, Level of EML4-ALK mRNA in NSCLC cells. Total RNA extracted from the indicated cell lines was subjected to RT and real-time PCR analysis for determination of the abundance of EML4-ALK mRNA. Data were normalized by the amount of GAPDH mRNA and then expressed relative to the corresponding value for H3122 cells, and they are means from three independent experiments.
Supplementary Figure 6 from Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance
Authors: Ambrosini Grazia , Pratilas Christine A. , Qin Li-Xuan , Tadi Madhavi , Surriga Oliver , Carvajal Richard D. , Schwartz Gary K.
Published: April 2023

PDF file, 2048KB, Effects of knockdown of GNAQ or CDK5R1 and selumetinib on cell migration of uveal melanoma.
Supplementary Figure 5 from Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance
Authors: Ambrosini Grazia , Pratilas Christine A. , Qin Li-Xuan , Tadi Madhavi , Surriga Oliver , Carvajal Richard D. , Schwartz Gary K.
Published: April 2023

PDF file, 997KB, DDX21 knockdown contributes to the anti-proliferative effects of selumetinib in GNAQ mutant cells.
Supplementary Figure 1 from A Personalized Preclinical Model to Evaluate the Metastatic Potential of Patient-Derived Colon Cancer Initiating Cells
Authors: Puig Isabel , Chicote Irene , Tenbaum Stephan P. , Arqués Oriol , Herance José Raúl , Gispert Juan D. , Jimenez José , Landolfi Stefania , Caci Karina , Allende Helena , Mendizabal Leire , Moreno Debora , Charco Ramón , Espín Eloy , Prat Aleix , Elez Maria Elena , Argilés Guillem , Vivancos Ana , Tabernero Josep , Rojas Santiago , Palmer Héctor G.
Published: April 2023

PDF file - 674K, Histological characterization of patients' carcinomas and the correspondent xenograft tumors.
Supplementary Figure 1 from Targeted MET Inhibition in Castration-Resistant Prostate Cancer: A Randomized Phase II Study and Biomarker Analysis with Rilotumumab plus Mitoxantrone and Prednisone
Authors: Ryan Charles J. , Rosenthal Mark , Ng Siobhan , Alumkal Joshi , Picus Joel , Gravis Gwenaëlle , Fizazi Karim , Forget Frédéric , Machiels Jean-Pascal , Srinivas Sandy , Zhu Min , Tang Rui , Oliner Kelly S. , Jiang Yizhou , Loh Elwyn , Dubey Sarita , Gerritsen Winald R.
Published: April 2023

PDF file - 883K, Patient disposition by treatment group. IP, investigational product; MP, mitoxantrone and prednisone. *Patient had a decrease in hemoglobin prior to administration of IP on day 1 of cycle 1. �Patient had delays to cycles prior to cycle 12.
Supplementary Table 1 from A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients
Authors: Eechoute Karel , Fransson Martin N. , Reyners An K. , de Jong Floris A. , Sparreboom Alex , van der Graaf Winette T.A. , Friberg Lena E. , Schiavon Gaia , Wiemer Erik A.C. , Verweij Jaap , Loos Walter J. , Mathijssen Ron H.J. , De Giorgi Ugo
Published: April 2023

PDF file, 77K, Association analysis between imatinib trough concentrations and progression free survival.
Supplementary Figure Legend and Tables 1 - 5 from IGKV3 Proteins as Candidate “Off-the-Shelf” Vaccines for Kappa-Light Chain–Restricted B-Cell Non-Hodgkin Lymphomas
Authors: Martorelli Debora , Guidoboni Massimo , De Re Valli , Muraro Elena , Turrini Riccardo , Merlo Anna , Pasini Elisa , Caggiari Laura , Romagnoli Luca , Spina Michele , Mortarini Roberta , Gasparotto Daniela , Mazzucato Mario , Carbone Antonino , Rosato Antonio , Anichini Andrea , Dolcetti Riccardo
Published: April 2023

PDF file, 157KB, Supplementary Table 1. Patient data Supplementary Table 2. HLA-A and-B genotypes of donors from whom IGKV3-specific CTL lines were induced and extent of specific cytotoxicity against IGKV3-15 or IGKV3-20 proteins Supplementary Table 3. Differentiation features of T cell cultures induced with recombinant IGKV3 proteins from PBMCs of healthy donors Supplementary Table 4: Relative affinity and complex stability data for IGKV3-20-derived peptides. Supplementary Table 5. "Variant" IGKV3-20 epitopes carried by different IGK chains broadly expressed by B cell lymphomas
Supplementary Table and Figure from Molecular Pathways: Interferon/Stat1 Pathway: Role in the Tumor Resistance to Genotoxic Stress and Aggressive Growth
Authors: Khodarev Nikolai N. , Roizman Bernard , Weichselbaum Ralph R.
Published: April 2023

PDF file - 75K, ISGs associated with genotoxic stress
Supplementary Figure Legend 1, Table Legends 1-5 from PIK3CA/PTEN Mutations and Akt Activation As Markers of Sensitivity to Allosteric mTOR Inhibitors
Authors: Meric-Bernstam Funda , Akcakanat Argun , Chen Huiqin , Do Kim-Anh , Sangai Takafumi , Adkins Farrell , Gonzalez-Angulo Ana Maria , Rashid Asif , Crosby Katherine , Dong Mei , Phan Alexandria T. , Wolff Robert A. , Gupta Sanjay , Mills Gordon B. , Yao James
Published: April 2023

PDF file - 49K
Supplementary Figure 3 from Synthetic miR-34a Mimics as a Novel Therapeutic Agent for Multiple Myeloma: In Vitro and In Vivo Evidence
Authors: Di Martino Maria T. , Leone Emanuela , Amodio Nicola , Foresta Umberto , Lionetti Marta , Pitari Maria R. , Cantafio Maria E. Gallo , Gullà Annamaria , Conforti Francesco , Morelli Eugenio , Tomaino Vera , Rossi Marco , Negrini Massimo , Ferrarini Manlio , Caraglia Michele , Shammas Masood A. , Munshi Nikhil C. , Anderson Kenneth C. , Neri Antonino , Tagliaferri Pierosandro , Tassone Pierfrancesco
Published: April 2023

PDF file - 100K, Transduction efﬁciency of MM cells
Supplementary Figure 2 from Synthetic miR-34a Mimics as a Novel Therapeutic Agent for Multiple Myeloma: In Vitro and In Vivo Evidence
Authors: Di Martino Maria T. , Leone Emanuela , Amodio Nicola , Foresta Umberto , Lionetti Marta , Pitari Maria R. , Cantafio Maria E. Gallo , Gullà Annamaria , Conforti Francesco , Morelli Eugenio , Tomaino Vera , Rossi Marco , Negrini Massimo , Ferrarini Manlio , Caraglia Michele , Shammas Masood A. , Munshi Nikhil C. , Anderson Kenneth C. , Neri Antonino , Tagliaferri Pierosandro , Tassone Pierfrancesco
Published: April 2023

PDF file - 73K, TP53-wild type MM cells were not inhibited by miR-34a inhibitor transfection
Supplementary Methods from A Phase I Dose-Escalation Trial of Trastuzumab and Alvespimycin Hydrochloride (KOS-1022; 17 DMAG) in the Treatment of Advanced Solid Tumors
Authors: Jhaveri Komal , Miller Kathy , Rosen Lee , Schneider Bryan , Chap Linnea , Hannah Alison , Zhong Ziyang , Ma Weining , Hudis Clifford , Modi Shanu
Published: April 2023

PDF file, 37K, Human PBMCs Sample Preparation, Western Blot assay for Hsp90 Client Proteins, Luminex Assay for Hsp90 Client Proteins.
Supplementary Figures 1-6 from Phenylarsine Oxide Induces Apoptosis in Bax- and Bak-Deficient Cells through Upregulation of Bim
Authors: Ni Biyun , Ma Qi , Li Baowei , Zhao Lixia , Liu Yong , Zhu Yushan , Chen Quan
Published: April 2023

Supplementary Figures 1-6 from Phenylarsine Oxide Induces Apoptosis in Bax- and Bak-Deficient Cells through Upregulation of Bim
Related Article from Biomarkers for EGFR-Antagonist Response: In the Genes and on the Genes!
Authors: Easwaran Hariharan , Baylin Stephen B.
Published: April 2023

Related Article from Biomarkers for EGFR-Antagonist Response: In the Genes and on the Genes!
Supplementary Table 2 from A Multicenter Phase I Trial of PX-866, an Oral Irreversible Phosphatidylinositol 3-Kinase Inhibitor, in Patients with Advanced Solid Tumors
Authors: Hong David S. , Bowles Daniel W. , Falchook Gerald S. , Messersmith Wells A. , George Goldy C. , O'Bryant Cindy L. , Vo Alex C. H. , Klucher Kevin , Herbst Roy S. , Eckhardt S. Gail , Peterson Scott , Hausman Diana F. , Kurzrock Razelle , Jimeno Antonio
Published: April 2023

PDF file, 50KB, Mutation Status for Arm 2 and Food Effects Arm.
Supplementary Figure Legend from A Multicenter Phase I Trial of PX-866, an Oral Irreversible Phosphatidylinositol 3-Kinase Inhibitor, in Patients with Advanced Solid Tumors
Authors: Hong David S. , Bowles Daniel W. , Falchook Gerald S. , Messersmith Wells A. , George Goldy C. , O'Bryant Cindy L. , Vo Alex C. H. , Klucher Kevin , Herbst Roy S. , Eckhardt S. Gail , Peterson Scott , Hausman Diana F. , Kurzrock Razelle , Jimeno Antonio
Published: April 2023

PDF file, 36KB.
Supplementary Figure 7 from An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
Authors: Byers Lauren Averett , Diao Lixia , Wang Jing , Saintigny Pierre , Girard Luc , Peyton Michael , Shen Li , Fan Youhong , Giri Uma , Tumula Praveen K. , Nilsson Monique B. , Gudikote Jayanthi , Tran Hai , Cardnell Robert J.G. , Bearss David J. , Warner Steven L. , Foulks Jason M. , Kanner Steven B. , Gandhi Varsha , Krett Nancy , Rosen Steven T. , Kim Edward S. , Herbst Roy S. , Blumenschein George R. , Lee J. Jack , Lippman Scott M. , Ang K. Kian , Mills Gordon B. , Hong Waun K. , Weinstein John N. , Wistuba Ignacio I. , Coombes Kevin R. , Minna John D. , Heymach John V.
Published: April 2023

PDF file - 27K, SGI-7079 and erlotinib do not adversely affect animal body weight
Supplementary Table 2 from Genome-Wide miRNA Expression Profiling Identifies miR-9-3 and miR-193a as Targets for DNA Methylation in Non–Small Cell Lung Cancers
Authors: Heller Gerwin , Weinzierl Marlene , Noll Christian , Babinsky Valerie , Ziegler Barbara , Altenberger Corinna , Minichsdorfer Christoph , Lang György , Döme Balazs , End-Pfützenreuter Adelheid , Arns Britt-Madeleine , Grin Yuliya , Klepetko Walter , Zielinski Christoph C. , Zöchbauer-Müller Sabine
Published: April 2023

PDF file - 23K
Supplementary Table 3 from Combined Alloreactive CTL Cellular Therapy with Prodrug Activator Gene Therapy in a Model of Breast Cancer Metastatic to the Brain
Authors: Hickey Michelle J. , Malone Colin C. , Erickson Kate L. , Lin Amy , Soto Horacio , Ha Edward T. , Kamijima Shuichi , Inagaki Akihito , Takahashi Masamichi , Kato Yuki , Kasahara Noriyuki , Mueller Barbara M. , Kruse Carol A.
Published: April 2023

PDF file - 282K, Biodistribution of RRV in brain / brain tumor and other tissues derived from animals within Figure 6 treatment groups.
Supplementary Figure 1 from Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro
Authors: Patel Anand G. , De Lorenzo Silvana B. , Flatten Karen S. , Poirier Guy G. , Kaufmann Scott H.
Published: April 2023

PDF file - 111K
Supplementary Table 2 from Combined Alloreactive CTL Cellular Therapy with Prodrug Activator Gene Therapy in a Model of Breast Cancer Metastatic to the Brain
Authors: Hickey Michelle J. , Malone Colin C. , Erickson Kate L. , Lin Amy , Soto Horacio , Ha Edward T. , Kamijima Shuichi , Inagaki Akihito , Takahashi Masamichi , Kato Yuki , Kasahara Noriyuki , Mueller Barbara M. , Kruse Carol A.
Published: April 2023

PDF file - 130K, HLA class I types of 231 stimulator cells and of the allodonors supplying precursor alloCTL for the experimental studies.
Supplementary Table 1 from Combined Alloreactive CTL Cellular Therapy with Prodrug Activator Gene Therapy in a Model of Breast Cancer Metastatic to the Brain
Authors: Hickey Michelle J. , Malone Colin C. , Erickson Kate L. , Lin Amy , Soto Horacio , Ha Edward T. , Kamijima Shuichi , Inagaki Akihito , Takahashi Masamichi , Kato Yuki , Kasahara Noriyuki , Mueller Barbara M. , Kruse Carol A.
Published: April 2023

PDF file - 114K, HLA-ABC expression on human breast cancer cell lines with and without IFNγ incubation.
Supplementary Figure Legend from Combined Alloreactive CTL Cellular Therapy with Prodrug Activator Gene Therapy in a Model of Breast Cancer Metastatic to the Brain
Authors: Hickey Michelle J. , Malone Colin C. , Erickson Kate L. , Lin Amy , Soto Horacio , Ha Edward T. , Kamijima Shuichi , Inagaki Akihito , Takahashi Masamichi , Kato Yuki , Kasahara Noriyuki , Mueller Barbara M. , Kruse Carol A.
Published: April 2023

PDF file - 73K
Supplementary Figure 7 from Sensitization of Pancreatic Cancer to Chemoradiation by the Chk1 Inhibitor MK8776
Authors: Engelke Carl G. , Parsels Leslie A. , Qian Yushen , Zhang Qiang , Karnak David , Robertson Jordan R. , Tanska Daria M. , Wei Dongping , Davis Mary A. , Parsels Joshua D. , Zhao Lili , Greenson Joel K. , Lawrence Theodore S. , Maybaum Jonathan , Morgan Meredith A.
Published: April 2023

PDF file, 297K, Phosphorylated Chk1 (S345) in MiaPaCa-2 xenograft slices.
Supplementary Figure 2 from 2-(3-{1-Carboxy-5-[(6-[18F]Fluoro-Pyridine-3-Carbonyl)-Amino]-Pentyl}-Ureido)-Pentanedioic Acid, [18F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer
Authors: Chen Ying , Pullambhatla Mrudula , Foss Catherine A. , Byun Youngjoo , Nimmagadda Sridhar , Senthamizhchelvan Srinivasan , Sgouros George , Mease Ronnie C. , Pomper Martin G.
Published: April 2023

PDF file - 97K
Supplementary Figure 1 from 2-(3-{1-Carboxy-5-[(6-[18F]Fluoro-Pyridine-3-Carbonyl)-Amino]-Pentyl}-Ureido)-Pentanedioic Acid, [18F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer
Authors: Chen Ying , Pullambhatla Mrudula , Foss Catherine A. , Byun Youngjoo , Nimmagadda Sridhar , Senthamizhchelvan Srinivasan , Sgouros George , Mease Ronnie C. , Pomper Martin G.
Published: April 2023

PDF file - 99K
Supplementary Figure 2B from A Phase I Trial and Pharmacokinetic Study of Sorafenib in Children with Refractory Solid Tumors or Leukemias: A Children's Oncology Group Phase I Consortium Report
Authors: Widemann Brigitte C. , Kim AeRang , Fox Elizabeth , Baruchel Sylvain , Adamson Peter C. , Ingle Ashish M. , Bender Julia Glade , Burke Michael , Weigel Brenda , Stempak Diana , Balis Frank M. , Blaney Susan M.
Published: April 2023

PDF file, 38K, Plasma soluble VEGFR2 (A) and Placental Growth Factor (B) concentrations prior to therapy (baseline) and at the end of cycle 1 (steady state).
Supplementary Table 1 from A Randomized, Multicenter, Placebo-Controlled Clinical Trial of Racotumomab-Alum Vaccine as Switch Maintenance Therapy in Advanced Non–Small Cell Lung Cancer Patients
Authors: Alfonso Sailyn , Valdés-Zayas Anet , Santiesteban Eduardo R. , Flores Yoanna I. , Areces Fernando , Hernández Maurenis , Viada Carmen E. , Mendoza Ivis C. , Guerra Pedro P. , García Elena , Ortiz Ramón A. , de la Torre Ana V. , Cepeda Meylán , Pérez Kirenia , Chong Eric , Hernández Ana María , Toledo Darien , González Zuyén , Mazorra Zaima , Crombet Tania , Pérez Rolando , Vázquez Ana María , Macías Amparo E.
Published: April 2023

PDF file - 47KB, Adverse event severity.
Supplementary Figure Legends from A Randomized, Multicenter, Placebo-Controlled Clinical Trial of Racotumomab-Alum Vaccine as Switch Maintenance Therapy in Advanced Non–Small Cell Lung Cancer Patients
Authors: Alfonso Sailyn , Valdés-Zayas Anet , Santiesteban Eduardo R. , Flores Yoanna I. , Areces Fernando , Hernández Maurenis , Viada Carmen E. , Mendoza Ivis C. , Guerra Pedro P. , García Elena , Ortiz Ramón A. , de la Torre Ana V. , Cepeda Meylán , Pérez Kirenia , Chong Eric , Hernández Ana María , Toledo Darien , González Zuyén , Mazorra Zaima , Crombet Tania , Pérez Rolando , Vázquez Ana María , Macías Amparo E.
Published: April 2023

PDF file - 61KB
Supplementary Figures 1-5, Tables 1-2 from TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence
Authors: Skinner Heath D. , Sandulache Vlad C. , Ow Thomas J. , Meyn Raymond E. , Yordy John S. , Beadle Beth M. , Fitzgerald Alison L. , Giri Uma , Ang K. Kian , Myers Jeffrey N.
Published: April 2023

PDF file - 372K
Supplementary Table 1 from Sorafenib or Placebo with Either Gemcitabine or Capecitabine in Patients with HER-2–Negative Advanced Breast Cancer That Progressed during or after Bevacizumab
Authors: Schwartzberg Lee S. , Tauer Kurt W. , Hermann Robert C. , Makari-Judson Grace , Isaacs Claudine , Beck J. Thaddeus , Kaklamani Virginia , Stepanski Edward J. , Rugo Hope S. , Wang Wei , Bell-McGuinn Katherine , Kirshner Jeffrey J. , Eisenberg Peter , Emanuelson Richard , Keaton Mark , Levine Ellis , Medgyesy Diana C. , Qamar Rubina , Starr Alexander , Ro Sunhee Kwon , Lokker Nathalie A. , Hudis Clifford A.
Published: April 2023

PDF file - 44K, Sensitivity Analyses of Progression-free Survival
Data Supplement from PBX1 Is a Favorable Prognostic Biomarker as It Modulates 13-cis Retinoic Acid–Mediated Differentiation in Neuroblastoma
Authors: Shah Nilay , Wang Jianjun , Selich-Anderson Julia , Graham Garrett , Siddiqui Hasan , Li Xin , Khan Javed , Toretsky Jeffrey
Published: April 2023

Supplementary Tables 1-4: Table 1: Individual RT-qPCR results for tumors samples from Figure 6A. Table 2: Univariate and multivariate analysis of PBX1 and clinical factors on EFS and OS in Oberthuer dataset. Table 3: Univariate and multivariate analysis of PBX1 and clinical factors on EFS and OS in Khan dataset. Table 4: Univariate analysis of other TALE family genes on survival in Oberthuer, Khan, and Asgharzadeh datasets.
Supplementary Figures 1 - 6 from TRAIL and Noxa Are Selectively Upregulated in Prostate Cancer Cells Downstream of the RIG-I/MAVS Signaling Pathway by Nonreplicating Sendai Virus Particles
Authors: Matsushima-Miyagi Taeko , Hatano Koji , Nomura Motonari , Li-Wen Liu , Nishikawa Tomoyuki , Saga Kotaro , Shimbo Takashi , Kaneda Yasufumi
Published: April 2023

PDF file - 395K, Figure S1. Selective apoptosis in DU145 cells induced by HVJ-E. Figure S2. The effect of poly (I:C) on cell survival. Figure S3. No significant changes in the expression of Bax, Puma, Bcl-xL or Bcl-2 were observed in cells treated with HVJ-E. Figure S4. Selective expression of the death receptors for TRAIL in PC3 cells and the decoy receptors for TRAIL in PNT2 cells. Figure S5. Suppression of HVJ-E-induced cell death by IRF7 siRNA in PC3 cells and by IRF3 siRNA in DU145 cells. Figure S6. Histological analysis and TUNEL staining of subcutaneous tumors injected with HVJ-E.
Supplementary Tables 1 - 2 from A Phase I Weekly Dosing Study of Brentuximab Vedotin in Patients with Relapsed/Refractory CD30-Positive Hematologic Malignancies
Authors: Fanale Michelle A. , Forero-Torres Andres , Rosenblatt Joseph D. , Advani Ranjana H. , Franklin Anna R. , Kennedy Dana A. , Han Tae H. , Sievers Eric L. , Bartlett Nancy L.
Published: April 2023

PDF file - 73KB, Suppl Table 1. Multiple Dose Pharmacokinetic Parameters for MMAE Suppl Table 2. Best Clinical Response Rate by Diagnosisa (efficacy evaluable population).
Supplementary Legends from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Authors: Zannella Vanessa E. , Dal Pra Alan , Muaddi Hala , McKee Trevor D. , Stapleton Shawn , Sykes Jenna , Glicksman Rachel , Chaib Selim , Zamiara Paul , Milosevic Michael , Wouters Bradly G. , Bristow Robert G. , Koritzinsky Marianne
Published: April 2023

PDF file 81K, Supplementary Legends
Figure S5 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Authors: Zannella Vanessa E. , Dal Pra Alan , Muaddi Hala , McKee Trevor D. , Stapleton Shawn , Sykes Jenna , Glicksman Rachel , Chaib Selim , Zamiara Paul , Milosevic Michael , Wouters Bradly G. , Bristow Robert G. , Koritzinsky Marianne
Published: April 2023

PDF file 54K, Figure S5 shows blood glucose levels in mice after metformin treatment
Supplementary Tables 1-2 from Performance of p16/Ki-67 Immunostaining to Detect Cervical Cancer Precursors in a Colposcopy Referral Population
Authors: Wentzensen Nicolas , Schwartz Lauren , Zuna Rosemary E. , Smith Katie , Mathews Cara , Gold Michael A. , Allen R. Andy , Zhang Roy , Dunn S. Terence , Walker Joan L. , Schiffman Mark
Published: April 2023

PDF file - 57K, Supplementary table 1: Clinical performance of p16/Ki-67, HR-HPV, and HPV16/18 to detect CIN2+ (n=91) or CIN3+ (n=20) for LSIL triage Supplementary table 2: Clinical performance of p16/Ki-67 and HPV16/18 to detect CIN2+ (n=33) or CIN3+ (n=12) for HR-HPV-positive ASC-US triage
Figure S3 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Authors: Zannella Vanessa E. , Dal Pra Alan , Muaddi Hala , McKee Trevor D. , Stapleton Shawn , Sykes Jenna , Glicksman Rachel , Chaib Selim , Zamiara Paul , Milosevic Michael , Wouters Bradly G. , Bristow Robert G. , Koritzinsky Marianne
Published: April 2023

PDF file 77K, Figure S3 shows propensity score distribution in the unmatched and matched patient cohort
Figure S1 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Authors: Zannella Vanessa E. , Dal Pra Alan , Muaddi Hala , McKee Trevor D. , Stapleton Shawn , Sykes Jenna , Glicksman Rachel , Chaib Selim , Zamiara Paul , Milosevic Michael , Wouters Bradly G. , Bristow Robert G. , Koritzinsky Marianne
Published: April 2023

PDF file 209K, Figure S1 illustrates the method for IHC analysis. It also shows a reduction in hypoxic fraction after metformin exposure in POP-92S and LNCaP xenografts
Supplementary Figures 1 - 9 from Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome
Authors: Wang Zhigang C. , Birkbak Nicolai Juul , Culhane Aedín C. , Drapkin Ronny , Fatima Aquila , Tian Ruiyang , Schwede Matthew , Alsop Kathryn , Daniels Kathryn E. , Piao Huiying , Liu Joyce , Etemadmoghadam Dariush , Miron Alexander , Salvesen Helga B. , Mitchell Gillian , DeFazio Anna , Quackenbush John , Berkowitz Ross S. , Iglehart J. Dirk , Bowtell David D.L. , Matulonis Ursula A.
Published: April 2023

PDF file, 366K, Supplementary Figures 1-9: 1. LOH patterns on different array platforms, 2. Allelic imbalance in LOH clusters, 3. LOH clustering breast cancer, 4. LOH and copy number prevalence in breast cancer, 5. Chemotherapy resistance and FLOH in three cohorts, 6. Chemotherapy resistance and FLOH with or without BRCA mutations, 7. PFS regardless of stage and residual disease, 8. PFS with or without BRCA mutations, 9. BRCA1 expression and FLOH.
Supplementary Methods and Figure Legend from A Comparative and Integrative Approach Identifies ATPase Family, AAA Domain Containing 2 as a Likely Driver of Cell Proliferation in Lung Adenocarcinoma
Authors: Fouret Robert , Laffaire Julien , Hofman Paul , Beau-Faller Michèle , Mazieres Julien , Validire Pierre , Girard Philippe , Camilleri-Bröet Sophie , Vaylet Fabien , Leroy-Ladurie François , Soria Jean-Charles , Fouret Pierre
Published: April 2023

PDF file, 102K.
Supplementary Table 2 from Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor–Transduced Human T cells in Solid Tumors
Authors: Moon Edmund K. , Wang Liang-Chuan , Dolfi Douglas V. , Wilson Caleph B. , Ranganathan Raghuveer , Sun Jing , Kapoor Veena , Scholler John , Puré Ellen , Milone Michael C. , June Carl H. , Riley James L. , Wherry E. John , Albelda Steven M.
Published: April 2023

PDF file - 37K, CAR spleen infiltrating lymphocytes have lower levels of inhibitory receptors than CAR tumor infiltrating lymphocytes.
Supplementary Figure 2 from A Comparative and Integrative Approach Identifies ATPase Family, AAA Domain Containing 2 as a Likely Driver of Cell Proliferation in Lung Adenocarcinoma
Authors: Fouret Robert , Laffaire Julien , Hofman Paul , Beau-Faller Michèle , Mazieres Julien , Validire Pierre , Girard Philippe , Camilleri-Bröet Sophie , Vaylet Fabien , Leroy-Ladurie François , Soria Jean-Charles , Fouret Pierre
Published: April 2023

PDF file, 686K, Heat maps of genes of the proliferative cluster (cluster f) according to ATAD2 expression, smoking status-associated discrete variables and disease stage in the LG cohort.
Supplementary Tables 1-3, Figure Legends 1-2 from Integrated Analysis Reveals Critical Genomic Regions in Prostate Tumor Microenvironment Associated with Clinicopathologic Phenotypes
Authors: Ashida Shingo , Orloff Mohammed S. , Bebek Gurkan , Zhang Li , Zheng Pan , Peehl Donna M. , Eng Charis
Published: April 2023

PDF file - 131K
Supplementary Figure 2A from Integrated Analysis Reveals Critical Genomic Regions in Prostate Tumor Microenvironment Associated with Clinicopathologic Phenotypes
Authors: Ashida Shingo , Orloff Mohammed S. , Bebek Gurkan , Zhang Li , Zheng Pan , Peehl Donna M. , Eng Charis
Published: April 2023

PDF file - 67K
Supplementary Figure Legend from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV
Authors: Yoo Ji Young , Pradarelli Jason , Haseley Amy , Wojton Jeffrey , Kaka Azeem , Bratasz Anna , Alvarez-Breckenridge Christopher A. , Yu Jun-Ge , Powell Kimerly , Mazar Andrew P. , Teknos Theodoros N. , Chiocca E. Antonio , Glorioso Joseph C. , Old Matthew , Kaur Balveen
Published: April 2023

PDF file, 77K.
Supplementary Figure 4 from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV
Authors: Yoo Ji Young , Pradarelli Jason , Haseley Amy , Wojton Jeffrey , Kaka Azeem , Bratasz Anna , Alvarez-Breckenridge Christopher A. , Yu Jun-Ge , Powell Kimerly , Mazar Andrew P. , Teknos Theodoros N. , Chiocca E. Antonio , Glorioso Joseph C. , Old Matthew , Kaur Balveen
Published: April 2023

PDF file, 65K, ATN-224 by itself does not affect glioma cell viability or oHSV efficacy in the absence of copper.
Supplementary Figure 4 from Pharmacokinetic and Pharmacodynamic Analysis of Circulating Biomarkers of Anti-NRP1, a Novel Antiangiogenesis Agent, in Two Phase I Trials in Patients with Advanced Solid Tumors
Authors: Xin Yan , Li Jessica , Wu Jenny , Kinard Rashell , Weekes Colin D. , Patnaik Amita , LoRusso Patricia , Brachmann Rainer , Tong Raymond K. , Yan Yibing , Watts Ryan , Bai Shuang , Hegde Priti S.
Published: April 2023

PDF file, 51K, Ratio to baseline for plasma VEGF from the days 2 or 28 time points for all animals administered a single dose of MNRP1685A at varying dose levels. Each dose level contained n=4 animals. Plasma VEGF was measured using an MSD assay.
Supplementary Figure 1 from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV
Authors: Yoo Ji Young , Pradarelli Jason , Haseley Amy , Wojton Jeffrey , Kaka Azeem , Bratasz Anna , Alvarez-Breckenridge Christopher A. , Yu Jun-Ge , Powell Kimerly , Mazar Andrew P. , Teknos Theodoros N. , Chiocca E. Antonio , Glorioso Joseph C. , Old Matthew , Kaur Balveen
Published: April 2023

PDF file, 46K, Quantification of color coded Ktrans and ve parametric images following DCE-MRI.
Supplementary Table 7 from A Signature Predicting Poor Prognosis in Gastric and Ovarian Cancer Represents a Coordinated Macrophage and Stromal Response
Authors: Busuttil Rita A. , George Joshy , Tothill Richard W. , Ioculano Kylie , Kowalczyk Adam , Mitchell Catherine , Lade Stephen , Tan Patrick , Haviv Izhak , Boussioutas Alex
Published: April 2023

XLS file - 23KB, Log-rank analysis for progression-free survival in patients with high and low expression of HOPACH clusters.
Supplementary Table 11 from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
Authors: Mydlarz Wojciech , Uemura Mamoru , Ahn Sun , Hennessey Patrick , Chang Steven , Demokan Semra , Sun Wenyue , Shao Chunbo , Bishop Justin , Krosting Julie , Mambo Elizabeth , Westra William , Ha Patrick , Sidransky David , Califano Joseph
Published: April 2023

XLSX file - 886K, Differentially expressed mRNAs in HNSCC tumors.
Supplementary Table 10 from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
Authors: Mydlarz Wojciech , Uemura Mamoru , Ahn Sun , Hennessey Patrick , Chang Steven , Demokan Semra , Sun Wenyue , Shao Chunbo , Bishop Justin , Krosting Julie , Mambo Elizabeth , Westra William , Ha Patrick , Sidransky David , Califano Joseph
Published: April 2023

XLSX file - 34K, mRNA expression changes after transient transfection of miR-21 in NOKSI.
Supplementary Table 1 from Toward Prediction of Efficacy of Chemotherapy: A Proof of Concept Study in Lung Cancer Patients Using [11C]docetaxel and Positron Emission Tomography
Authors: van der Veldt Astrid A.M. , Lubberink Mark , Mathijssen Ron H.J. , Loos Walter J. , Herder Gerarda J.M. , Greuter Henri N. , Comans Emile F.I. , Rutten Hugo B. , Eriksson Jonas , Windhorst Albert D. , Hendrikse N. Harry , Postmus Pieter E. , Smit Egbert F. , Lammertsma Adriaan A.
Published: April 2023

PDF File - 77K, Supplementary data showing measurements in evaluable tumors.
Supplementary Materials and Methods, Figure Legends, Figures 1 - 9, Tables 1 - 4 from Interleukin-32 Increases Human Gastric Cancer Cell Invasion Associated with Tumor Progression and Metastasis
Authors: Tsai Chung-Ying , Wang Chia-Siu , Tsai Ming-Ming , Chi Hsiang-Cheng , Cheng Wan-Li , Tseng Yi-Hsin , Chen Cheng-Yi , Lin Crystal D. , Wu Jun-I. , Wang Lu-Hai , Lin Kwang-Huei
Published: April 2023

PDF file - 1228KB, Supplementary Table SI. Primary antibody for western blot. Supplementary Table SII. Primary antibody for immunohistochemistry. Supplementary Table SIII. ShRNA for gene silencing. Supplementary Table SIV. Inhibitors for kinase inhibition. Supplemental Materials and Methods. Supplemental Figures and Legends. Supplementary Figure S1. IL-32 is overexpressing in GC specimens. Supplementary Figure S2. Ectopic overexpression of IL-32 promotes migration in TSGH9201 cells. Supplementary Figure S3. IL-32 enhances cell invasion and beta-catenin activity in a doxycycline-inducible expression system. Supplementary Figure S4. PI3K/AKT inhibitor (LY294002) diminishes IL-32-induced IL-8 expression. Supplementary Figure S5. Inhibition of phospho-AKT by MK-2206 attenuates expression of IL-32-induced downstream molecules as well as cell invasion ability. Supplementary Figure S6. Depletion of IL-32 in TSGH9201 and AGS cell lines. Supplementary Figure S7. Scatter plots of IL-32 and its downstream effectors in Spearman rank correlation analysis. Supplementary Figure S8. Rac GTPase signaling is partially involved in IL-32-induced cell migration. Supplementary Figure S9. HIF-1alpha mediated IL32-induced IL8, VEGF, MMP2 and MMP9 expression as well as cell invasion via a beta-catenin independent pathway.
Supplementary Figure 1 from Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363
Authors: Lamoureux Francois , Thomas Christian , Crafter Claire , Kumano Masafumi , Zhang Fan , Davies Barry R. , Gleave Martin E. , Zoubeidi Amina
Published: April 2023

PDF file - 70 KB, AZD5363 induces apoptosis in LNCaP prostate tumor cell line.
Supplementary Methods, Figure Legends from COX-2–Independent Effects of Celecoxib Sensitize Lymphoma B Cells to TRAIL-Mediated Apoptosis
Authors: Gallouet Anne-Sophie , Travert Marion , Bresson-Bepoldin Laurence , Guilloton Fabien , Pangault Céline , Caulet-Maugendre Sylvie , Lamy Thierry , Tarte Karin , Guillaudeux Thierry
Published: April 2023

PDF file - 176K
Supplementary Figure 1 from COX-2–Independent Effects of Celecoxib Sensitize Lymphoma B Cells to TRAIL-Mediated Apoptosis
Authors: Gallouet Anne-Sophie , Travert Marion , Bresson-Bepoldin Laurence , Guilloton Fabien , Pangault Céline , Caulet-Maugendre Sylvie , Lamy Thierry , Tarte Karin , Guillaudeux Thierry
Published: April 2023

PDF file - 34K, COX1 and COX-2 protein expressions were evaluated by western blotting in stromal cells, including HD-RESTO (n=4), FL-RESTO (n=4), FL-MSC (n=5) and HD-MSC (n=4). beta-actin was used as a loading control.
Table S2 from Targeting Treatment-Resistant Breast Cancer Stem Cells with FKBPL and Its Peptide Derivative, AD-01, via the CD44 Pathway
Authors: McClements Lana , Yakkundi Anita , Papaspyropoulos Angelos , Harrison Hannah , Ablett Matthew P. , Jithesh Puthen V. , McKeen Hayley D. , Bennett Rachel , Donley Christopher , Kissenpfennig Adrien , McIntosh Stuart , McCarthy Helen O. , O'Neill Eric , Clarke Robert B. , Robson Tracy
Published: April 2023

Table S2 - PDF file 86K, A: Clinical information and the average MFE for every solid primary breast tumour received; tumours of similar grade and status were combined and the average MFE calculated. B: Tumour initiation data following implantation of MCF-7 cells and AD-01 or PBS treatment from day 1 of implantation
Supplementary Data Legends from Targeting Treatment-Resistant Breast Cancer Stem Cells with FKBPL and Its Peptide Derivative, AD-01, via the CD44 Pathway
Authors: McClements Lana , Yakkundi Anita , Papaspyropoulos Angelos , Harrison Hannah , Ablett Matthew P. , Jithesh Puthen V. , McKeen Hayley D. , Bennett Rachel , Donley Christopher , Kissenpfennig Adrien , McIntosh Stuart , McCarthy Helen O. , O'Neill Eric , Clarke Robert B. , Robson Tracy
Published: April 2023

Supplementary Data Legends - PDF file 63K, Data legends for supplemental figs S1 to S7
Supplementary Table 1 from Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas
Authors: Zhao Qi , Caballero Otavia L. , Davis Ian D. , Jonasch Eric , Tamboli Pheroze , Yung W.K. Alfred , Weinstein John N. , Strausberg Robert L. , Yao Jun
Published: April 2023

XLSX file - 41K, Top candidate exons differentially expressed between normal kidney and ccRCCs
Figure S6 from Targeting Treatment-Resistant Breast Cancer Stem Cells with FKBPL and Its Peptide Derivative, AD-01, via the CD44 Pathway
Authors: McClements Lana , Yakkundi Anita , Papaspyropoulos Angelos , Harrison Hannah , Ablett Matthew P. , Jithesh Puthen V. , McKeen Hayley D. , Bennett Rachel , Donley Christopher , Kissenpfennig Adrien , McIntosh Stuart , McCarthy Helen O. , O'Neill Eric , Clarke Robert B. , Robson Tracy
Published: April 2023

Figure S6 - PDF file 42K, Figure S6. High FKBPL and low Sox2 expression shows a trend towards better patient survival. Samples with opposing FKBPL and Sox2 expression (high FKBPL/low Sox2 and low FKBPL/high Sox2) were analyzed using microarray data from publically available data set (GSE7390). Samples were stratified based on median expression values of Sox2 and FKBPL. Kaplan-Meier survival curves of breast cancer patients (n=104) presented
Supplementary Figure Legend from Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas
Authors: Zhao Qi , Caballero Otavia L. , Davis Ian D. , Jonasch Eric , Tamboli Pheroze , Yung W.K. Alfred , Weinstein John N. , Strausberg Robert L. , Yao Jun
Published: April 2023

PDF file - 44K
Supplementary Figure 6 from Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas
Authors: Zhao Qi , Caballero Otavia L. , Davis Ian D. , Jonasch Eric , Tamboli Pheroze , Yung W.K. Alfred , Weinstein John N. , Strausberg Robert L. , Yao Jun
Published: April 2023

PDF file - 420K, Correlation of ESRP1/GRHL2 gene expression level to FGFR2 gene expression level in normal kidney and ccRCC
Supplementary Figure 1 from Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas
Authors: Zhao Qi , Caballero Otavia L. , Davis Ian D. , Jonasch Eric , Tamboli Pheroze , Yung W.K. Alfred , Weinstein John N. , Strausberg Robert L. , Yao Jun
Published: April 2023

PDF file - 604K, Alternative splicing of the FGFR2 mRNA in normal kidney and clear cell renal cell carcinomas (ccRCC).
Supplementary Table & Figure Legends from Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo
Authors: Renshaw Jane , Taylor Kathryn R. , Bishop Ryan , Valenti Melanie , De Haven Brandon Alexis , Gowan Sharon , Eccles Suzanne A. , Ruddle Ruth R. , Johnson Louise D. , Raynaud Florence I. , Selfe Joanna L. , Thway Khin , Pietsch Torsten , Pearson Andrew D. , Shipley Janet
Published: April 2023

Supplementary Table & Figure Legends - PDF file 41K, Detailed captions for: Suppl Table S1. Immunohistochemical analysis indicates correlation between pAKT(Ser473),pERK1/2(Thr202/Tyr204) and pS6(Ser235/236) in primary tumours Fig S1. High level expression of p110alpha in two of four ARMS cell lines. Fig S2. PIK3CA KD does not induce cell cycle arrest or apoptosis in the growth inhibited RMS cells. Fig S3. Downregulation of PTEN expression appears to be associated with delayed inhibition of AKT phosphorylation in RH30 cells following p110alpha KD. Fig S4 Increased sensitivity of the RMS-1 PIK3CA KD line to TGX221, and of the RMS-1, RD and RMS-YM KD lines to ZSTK474. Fig S5 Equivalent changes in the biomarkers of MAPK and PI3K activity at 6h in vivo, to those seen in vitro following acute dosing with AZD6244 and AZD8055 alone, and in combination, with recovery to control levels correlating with plasma and tumor clearance of both drugs. Fig S6 Tolerability study of twice daily dosing of 10mk/kg po AZD6244 and AZD8055 indicates reversible weight loss with combination treatment, while PK analysis of tail vein blood spots confirms drug-drug interactions. Fig S7 Dose-finding therapeutic study defines a once daily treatment schedule of AZD6244, 10mg/kg p.o., and AZD8055, 20mg/kg p.o., as well tolerated and active when given in combination
Supplementary Methods from Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo
Authors: Renshaw Jane , Taylor Kathryn R. , Bishop Ryan , Valenti Melanie , De Haven Brandon Alexis , Gowan Sharon , Eccles Suzanne A. , Ruddle Ruth R. , Johnson Louise D. , Raynaud Florence I. , Selfe Joanna L. , Thway Khin , Pietsch Torsten , Pearson Andrew D. , Shipley Janet
Published: April 2023

Supplementary Methods - PDF file 44K, Method for the preparation and analysis of AZD8055, AZD6244 and BEZ235 by LC-MS/MS Drug-drug interaction assay
Supplementary Table S9 from Effect of Aromatase Inhibition on Functional Gene Modules in Estrogen Receptor–Positive Breast Cancer and Their Relationship with Antiproliferative Response
Authors: Gao Qiong , Patani Neill , Dunbier Anita K. , Ghazoui Zara , Zvelebil Marketa , Martin Lesley-Ann , Dowsett Mitch
Published: April 2023

Spearman Rank Correlation Matrix (rho and p-value) of expression change in Gene Module Scores and Ki67, âˆ†log2Ki67 (log2(Ki67post) - log2(Ki67pre)). A: Including Proliferation-Associated Genes. B: Excluding Proliferation-Associated Genes.
Supplementary Table S2 from Effect of Aromatase Inhibition on Functional Gene Modules in Estrogen Receptor–Positive Breast Cancer and Their Relationship with Antiproliferative Response
Authors: Gao Qiong , Patani Neill , Dunbier Anita K. , Ghazoui Zara , Zvelebil Marketa , Martin Lesley-Ann , Dowsett Mitch
Published: April 2023

Summary of 69 patient demographics and tumour characteristics for pre-surgical studies of anastrozole (FAIMoS).
Supplementary Figure 1 from Neutrophils Promote the Malignant Glioma Phenotype through S100A4
Authors: Liang Ji , Piao Yuji , Holmes Lindsay , Fuller Gregory N. , Henry Verlene , Tiao Ningyi , de Groot John F.
Published: April 2023

PDF file 124K, Phosphorylated Erk, Akt (pErk, pAkt) and the total proteins were analysis in GSCs incubated with or without CM