bluuebunny/crossref_metadata_2025 huggingface dataset:
Opto-mechanical modeling and experimental implementation of an FBG-based piezoelectric bimorph actuator for high voltage sensing applications
Authors: Jiménez Raúl E , Montoya José P , Acuna Herrera Rodrigo
Published: July 2021

This paper proposes a highly simplified optical voltage sensor by using a piezoelectric bimorph and a Fiber Bragg Grating (FBG) that can be used for high voltage applications with a relatively good accuracy and stability. In this work the theoretical framework for the whole opto-mechanical operation of the optical sensor is detailed and compared to experimental results. In the analysis, a correction term to the electric field is derived to account for the linear strain distribution across the piezoelectric layer improving the designing equations and giving more criteria for future developments. Finally, some experimental results from a laboratory scale optical-based high voltage sensing setup are discussed, and shown to be in excellent agreement with theoretical expected behavior for different voltage magnitudes.
Estimating the forcing function in a mechanical system by an inverse calibration method
Authors: Rice Chapel , Frankel Jay I
Published: July 2021

This article proposes and demonstrates a calibration-based integral formulation for resolving the forcing function in a mass–spring–damper system, given either displacement or acceleration data. The proposed method is novel in the context of vibrations, being thoroughly studied in the field of heat transfer. The approach can be expanded and generalized further to multi-variable systems associated with machine parts, vehicle suspensions, translational and rotational systems, gear systems, etc. when mathematically described by a system of constant property, linear, time-invariant ordinary differential equations. The analytic approach and subsequent numerical reconstruction of the forcing function is based on resolving a parameter-free inverse formulation for the equation(s) of motion. The calibration approach is formulated in the frequency domain and takes advantage of several observations produced by the dimensionality reduction leading to an algebratized system involving an input–output relationship and a transfer function possessing all the system parameters. The transfer function is eliminated in lieu of experimental data, from a calibration effort, thus leading to a reduction of systematic errors. These parameter-free, reduced systematic error aspects are the distinct and novel advantages of the proposed method. A first-kind Volterra integral equation is formed containing only the unknown forcing function and experimental data. As with all ill-posed problems, regularization must be introduced for system stabilization. A future-time technique is instituted for forming a family of predictions based on the chosen regularization parameter. The optimal regularization parameter is estimated using a combination of phase–plane analysis and cross-correlation principles. Finally, a numerical simulation is performed verifying the proposed approach.
Application of Mixed Methods in Health Services Management Research: A Systematic Review
Authors: Lee Shoou-Yih D. , Iott Bradley , Banaszak-Holl Jane , Shih Shu-Fang , Raj Minakshi , Johnson Kimson E. , Kiessling Karalyn , Moore-Petinak N’dea
Published: July 2021

Mixed methods research (MMR) is versatile, pragmatic, and adaptable to constraints and opportunities during a research process. Although MMR has gain popularity in health services management research, little is known about how the research approach has been used and the quality of research. We conducted a systematic review of 198 MMR articles published in selected U.S.-based and international health services management journals from 2000 through 2018 to examine the extent of MMR application and scientific rigor. Results showed limited, yet increasing, use of MMR and a high degree of correspondence between MMR designs and study purposes. However, most articles did not clearly justify using MMR designs and the reporting of method details and research integration were inadequate in a significant portion of publications. We propose a checklist to assist the preparation and review of MMR manuscripts. Additional implications and recommendations to improve transparency, rigor, and quality in MMR are discussed.
HER-2 Neu gene: A valuable therapeutic target in metastatic mucoepidermoid carcinoma
Authors: Mohammed Turab , Mangeshkar Shaunak , Desai Aakash , Hegde Upendra
Published: July 2021

Introduction

Salivary gland neoplasms (SGNs) respond poorly to the traditional chemotherapy agents limiting the availability of systemic treatment options in the metastatic setting. The recent identification of actionable molecular targets in SGNs has led to the evaluation of targeted therapies in non-approved advanced SGNs.

Case Report

We present the case of an elderly male with HER-2 Neu overexpressing metastatic mucoepidermoid carcinoma (MEC) who demonstrated a prompt and sustained disease response to targeted therapies directed against HER-2 Neu with long survival interrupted by hepatoxicity to Trastuzumab emtansine (TDM-1) treatment. Management and Outcome: The patient was started on Trastuzumab and Pertuzumab on a clinical trial and resulted in an objective improvement sustained over 3 years. Following the disease progression, TDM-1 was started with a response until the patient developed severe hepatotoxicity as an adverse effect of TDM-1 therapy resulting in its discontinuation. Close follow-up post-treatment-discontinuation demonstrated continued clinical improvement until 6 months, when the patient developed brain metastasis. He passed away a few months later in hospice care.

Discussion

The metastatic MEC in our patient overexpressed HER-2 Neu. Owing to Trastuzumab and Pertuzumab response, Trastuzumab emtansine (TDM-1) was initiated on a compassionate basis which further extended the survival but had to be terminated owing to adverse effects. Given the paucity of data on targeted therapies in the treatment of metastatic SGNs and the safety, tolerability, and efficacy of TDM-1 therapy among the elderly, further studies are warranted to answer these important questions and to identify eligible patients for this novel treatment option.
Bilateral iris mass as the first manifestation of NK cell lymphoma: A case report
Authors: Qian Yiwen , Shen Jun , Che Xin , Yuan Yan , Wang Zhiliang
Published: July 2021

Introduction:

Natural killer (NK) cell lymphoma is a progressive non-Hodgkin’s lymphoma with rare prevalence. Intraocular involvement of NK cell lymphoma is very rare, with only case reports to date.

Case presentation:

Here, we report a case of intraocular involvement of NK cell lymphoma which was presented with bilateral uveitis, iris mass, and diffuse infiltration into the center nerve system (CNS), skin, and possibly myocardium.

Conclusions:

Iris mass and uveitis which is not responsive to steroids may be ocular manifestations of intraocular lymphoma, such as NK cell lymphoma. Ophthalmological and systemic examinations should be required for early diagnosis and treatment.
Short-term effectiveness prognostic factors after dexamethasone intravitreal implant in macular edema due to retinal vein occlusion
Authors: Garay-Aramburu Gonzaga , Gómez-Moreno Ángela , Urcola Aritz
Published: July 2021

Introduction:

The aim of this study was to describe functional and anatomical changes (best-corrected visual acuity [BCVA], central macular thickness [CMT], and central macular volume [CMV]) in patients with macular edema (ME) secondary to retinal vein occlusion (RVO) treated with intravitreal dexamethasone implant (IDI) and identify its clinical predictors in a real-world setting.

Methods:

Data from 111 patients who underwent IDI to treat RVO-associated ME were retrospectively reviewed. Demographic, preoperative, and postoperative variables were assessed using a logistic regression analysis to determine predictors of visual and anatomical improvement.

Results:

Mean BCVA, CMT, and CMV improved from baseline after IDI ( p < 0.001). The strongest predictors of different treatment outcomes were: a baseline BCVA ⩽60 ETDRS letters (OR = 50.600; p < 0.001) and first IDI injection (OR = 2.988; p < 0.001) for BCVA gain ⩾15 Early Treatment Diabetic Retinopathy Study (ETDRS) letters; a baseline BCVA ⩽60 ETDRS letters (OR = 7.893; p = 0.002) and non-chronic ME (OR = 3.875; p = 0.019) for BCVA ⩾80 ETDRS letters achievement; a baseline CMT ⩾400 µm (OR = 49.083; p  < 0.001) and a baseline CMV ⩾12 mm3 (OR = 4.235; p < 0.001) for CMT reduction ⩾50%; and a baseline CMT ⩾400 µm (OR = 11.471; p  < 0.001) and a baseline CMV ⩾12 mm3 (OR = 10.284; p < 0.001) for CMV reduction ⩾15%.

Conclusion:

This study confirmed the effectiveness of IDI to treat ME secondary to RVO and identified new predictive factors for two visual (⩾15 ETDRS letters gain and BCVA ⩾80 ETDRS letters) and two anatomical outcomes (>50% CMT and >15% CMV reduction).
Testing Possible Scenario-Based Responses of Vegetation Under Expected Climatic Changes in Khuzestan Province
Authors: Eskandari Damaneh Hadi , Jafari Meysam , Eskandari Damaneh Hamed , Behnia Marjan , Khoorani Asadollah , Tiefenbacher John P.
Published: July 2021

Projections of future scenarios are scarce in developing countries where human activities are increasing and impacting land uses. We present a research based on the assessment of the baseline trends of normalized difference vegetation index (NDVI), precipitation, and temperature data for the Khuzestan Province, Iran, from 1984 to 2015 compiled from ground-based and remotely sensed sources. To achieve this goal, the Sen’s slope estimator, the Mann-Kendall test, and Pearson’s correlation test were used. After that, future trends in precipitation and temperature were estimated using the Canadian Earth System Model (CanESM2) model and were then used to estimate the NDVI trend for two future periods: from 2016 to 2046 and from 2046 to 2075. Our results showed that during the baseline period, precipitation decreased at all stations: 33.3% displayed a significant trend and the others were insignificant ones. Over the same period, the temperature increased at 66.7% of stations while NDVI decreased at all stations. The NDVI–precipitation relationship was positive while NDVI–temperature showed an inverse trend. During the first of the possible future periods and under the RCP2.6, RCP4.5, and RCP8.5 scenarios, NDVI and precipitation decreased, and temperatures significantly increased. In addition, the same trends were observed during the second future period; most of these were statistically significant. We conclude that much assessments are valuable and integral components of effective ecosystem planning and decisions.
Numerical study on using vortex flow to improve smoke exhaust efficiency in large-scale atrium fires
Authors: Fang Xiang , Yuen Anthony CY , Yeoh Guan H , Lee Eric WM , Cheung Sherman CP
Published: July 2021

A high-performance smoke exhaust system is vital for maintaining a tenable environment during fire accidents evacuation. This study proposes a novel vortex flow driven smoke exhaust system to delay the smoke filling process during the atrium fire accident. The complex fluid movement and combustion reactions were predicted using Fire Dynamics Simulator, and the predicted smoke filling process was identified by the least-square method. Good agreements between numerical predictions and experimental measurements for vertical temperature, tangential velocity profile and smoke interface height were achieved. The numerical outcomes revealed that the amount of fresh air supplied, heat release rate and exhaust fan's rate determined the smoke interface's final height. A parametric study was also carried out to investigate the dominating factor in maintaining a stable vortex flow to maximize the smoke exhaust efficiency. Numerical results showed that the vortex flow smoke exhaust system could slow down the smoke filling, and the stability of the swirling fire is crucial for the system's performance.
The post-industrial English canalscape: from enclosure to enlacement
Authors: Wallace Andrew , Wright Katy
Published: July 2021

In this article we explore how the English post-industrial canal has gone from enclosed and abandoned urban ruin to thriving but contested urban landscape. We contend that canals deserve closer social scientific attention in and of themselves but also as a creative entry point for understanding the instabilities and ambivalences of contemporary urban life. We probe at three dynamics in the English context: uneven cycles of attention from state, capital and civil society that ‘revealed’ the canal over the course of the 20th century; how the contemporary canalscape is made ‘from below’ and how its unique materiality as a stretched, socio-natural waterway has been mobilised, latterly, in biopolitical ways. We note how the cultivated meaning of these previously enclosed industrial relics is now deeply entwined with the mood and mobility of urban dwellers. Methodologically, we excavate these three dimensions through a synthesis of phenomenological attunement and analysis of historical, literary and social scientific accounts.
The problem of critique in art-geography: five propositions for immanent evaluation after Deleuze
Authors: Williams Nina
Published: July 2021

This paper argues that we need to challenge transcendent modes of evaluating creative practices in geography, both in order to question dominant ways of thinking about creativity and to cultivate a broader playing field on which to transform concepts and practices of aesthetics. This is important because the intervention of creative research must be coupled with a framework that can amplify it and make it count thereafter, or we risk returning to a familiar conceptual apparatus over the greater challenge of developing how creative practices make us think differently. In doing so, the paper presents five propositions for immanent evaluation elaborated through Gilles Deleuze, which are crucial for exploring a plurality of ‘aesthetic justifications’. Empirically, the paper draws on an exhibition entitled Sounding the City, which the author curated in Bristol, UK, in August 2014. The aim is not to explore the politics of curation, but to experiment with a mode of presenting research that supports the propositions for evaluation staged in the paper.
Epidemiology of Homicide in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis
Authors: Kennedy Briohny , Bugeja Lyndal , Olivier Jake , Johnson Marilyn , Hua Phuong , Koppel Sjaan , Ibrahim Joseph E.
Published: July 2021

Background:

Empirical research investigating older adult homicide is sparse and rarely accumulated for greater insights. This systematic review and meta-analysis quantifies the prevalence and characteristics of homicide victimization among older adults (65 years and older) compared with younger adults (18–64 years).

Method:

We searched Cumulative Index to Nursing and Allied Health Literature, Cochrane, Criminal Justice Abstracts, EMBASE, MEDLINE, ProQuest, PsycINFO, Scopus, and Web of Science for studies published before December 31, 2018 (International Prospective Register of Systematic Reviews registration: CRD42017054536). Included were English-language, original, peer-reviewed studies describing the homicide of older adults. Excluded were studies not meeting age criteria, residence as an institution, or with insufficient outcome variables. The review included 39 studies; 17 were included in the meta-analysis. Data were extracted via open access or from study authors. Heterogeneity was assessed through study-level random effects estimates.

Results:

Pooled homicide rates per 100,000 population were 2.02 (95% CI [1.23, 3.33]) for older adults ( n = 35,325) and 3.98 (95% CI [2.42, 6.53]) for younger adults ( n = 607,224; rate ratio = .51, 95% CI [0.37, 0.70], p < .001). Proportion estimates for older adults: victim female 46.3%, location home 71.4%, offender familiar 25.2%, compared to stranger, 24.2%, motive argument 36.1%, compared to felony 30.8%, and weapon firearm 24.5%. Older adults were significantly different to younger adult victims ( p = <.001) for female ( OR = 2.5, 95% CI [2.02, 3.10]), home (3.87, 95% CI [3.45, 4.35]), stranger (1.81, 95% CI [1.66, 1.98]), argument (0.33, 95% CI [0.28, 0.39]), felony (2.78, 95% CI [2.58, 2.99]), and firearm (0.38, 95% CI [0.36, 0.40]).

Conclusions:

Homicide against older adults differs from younger adults and warrants specific research and tailored prevention strategies.
The Role of Arrest Risk Perception Formation in the Association Between Psychopathy and Aggressive Offending
Authors: Altikriti Sultan , Nedelec Joseph L. , Silver Ian
Published: July 2021

Research on the role of risk perception as a mechanism linking personality traits and behavioral outcomes is limited. The current study assessed a developmental model of the influence of psychopathic traits (PPTs) on the between- and within-individual variation in perceptions of risk and aggressive offending. Multivariate latent growth curve models were used to estimate the role of risk perceptions in the association between PPTs and aggressive offending in a sample of 1,354 adjudicated youths. The results indicated that PPTs influenced between-individual differences in perceptions of risk (β = −.312) and aggressive offending (β = .256), although the effects on within-individual differences suggested some attenuation over time. Additionally, higher PPT scores exhibited an indirect influence on increased aggressive offending through reduced perceptions of risk (β = .049). Implications from this line of research support calls for a developmentally informed juvenile justice system that considers latent personality traits and their long-term effects. Broader implications support individualized rehabilitative programming and tailored responses to offending over the blanket deterrence approach that dominates the current landscape of the American criminal justice system.
Navigating Ethical Issues in Photovoice: Balancing the Principles of Community-Based Participatory Research Ethics with Institutional Review Board Requirements
Authors: McDonald Lauren E. , Capous-Desyllas Moshoula
Published: July 2021

This article reflects on ethical issues that arose during the course of two different evaluation projects that used photovoice method to engage with marginalized populations. The evaluations serve as case studies for a critical discussion about potential barriers that researchers may face when employing photovoice method while trying to balance the principles of community-based participatory research with the requirements of Institutional Review Boards. We reflect on ethical dilemmas related to the meaning of photography within the cultural context of participants’ lives, the compensation of participants as collaborators, and the representation and dissemination of participant photos. We conclude by examining how researchers may approach ethical requirements without compromising the important collaborative relationships central to photovoice method. We additionally call on researchers to engage with ethics review committees to create a new “participant–researcher” category with its own set of protocols that recognizes the nuanced role members of disenfranchised communities play in the research process.
Nutritional management of surgically induced menopause: A case report
Authors: Ross Kim
Published: July 2021

Hot flashes are a primary reason for medical visits during menopause. They can interfere with sleep, cause mood disturbances, decrease the overall quality of life, and are associated with significant health care and societal costs. This case report examines the safety and effectiveness of Lepidium peruvianum (maca) for the management of menopausal-related symptoms. A 32-year-old White female presented with hot flashes, night sweats, anxiety, and mood changes following a hysterectomy and oophorectomy. She was provided with a personalized nutrition plan, Lepidium peruvianum (maca), targeted nutrient supplementation, and lifestyle recommendations. These interventions resulted in the safe and effective resolution of hot flashes and anxiety in 2 months and significantly improved her moods and sleep. This case report demonstrated that the use of Lepidium peruvianum, in conjunction with dietary and targeted supplement modifications, appeared to be safe and resulted in the rapid improvements and resolution of symptoms associated with menopause.
A metal-free approach for the synthesis of thiosulfonates from sulfonyl hydrazides
Authors: Li Xue , Liao WeiBo , Huang Bin , Zhang YuanYuan , Wang JiangWei
Published: July 2021

Without any metal catalyst, an efficient transformation of a variety of sulfonyl hydrazides into the corresponding thiosulfonates mediated by NBS/DABCO under air is developed. The method utilizes mild reaction conditions, affords moderate to good yields of product, and tolerates a broad substrate scope. A plausible mechanism is proposed for the decomposition of the sulfonyl hydrazides and the construction of S(O2)–S bonds to form thiosulfonates.
Allocating hot standbys to randomly weighted k-out-of-n: G systems
Authors: Sun Hong , Zhang Yiying , Zhao Peng
Published: July 2021

In industrial engineering applications, randomly weighted [Formula: see text]-out-of-[Formula: see text]: G systems can model many reliability systems whose components may contribute unequally and randomly to the systems’ performance. This paper investigates optimal allocations of hot standbys for [Formula: see text]-out-of-[Formula: see text]: G systems with random weights. First, optimal allocation policies are presented by maximizing the total capacity according to the usual stochastic ordering and the expectation ordering when the system is constituted by independent and heterogeneous components accompanied with independent random weights. Second, we investigate hot standbys allocation for randomly weighted [Formula: see text]-out-of-[Formula: see text]: G systems with right [left] tail weakly stochastic arrangement increasing random weights in the sense of the usual stochastic ordering [increasing concave ordering]. Simulation studies are provided to illustrate our theoretical findings as well. These established results can provide useful guidance for system designers on how to introduce hot standbys in randomly weighted [Formula: see text]-out-of-[Formula: see text]: G systems in order to enhance their total capacities.
Establishing a New Patient-Specific Implantation Technique for Total Ankle Replacement: An In Vitro Study
Authors: Claassen Leif , Luedtke Philipp , Nebel Dennis , Yao Daiwei , Ettinger Sarah , Daniilidis Kiriakos , Stukenborg-Colsman Christina , Plaass Christian
Published: July 2021

Background

Revision rates after total ankle replacements (TARs) are higher compared with other total joint replacements. The present study aimed to establish a new patient-specific implantation (PSI) technique for TAR.

Material and methods

A total of 10 complete Caucasian cadaver legs had whole leg computed tomography scans. The individual geometrical ankle joint axis was determined, and based on this axis, the position of the prosthesis was planned. We assessed prosthesis placement, guiding block position, and preoperative and postoperative ankle rotational axes.

Results

The guiding block position interobserver reliability was 0.37 mm 0.45 (mean ± SD) for the tibial guiding block. The value for the first talar guiding block was 1.72 ± 1.3 mm and for the second talar guiding block, 0.61 ± 0.39 mm. The tibial slope as well as the frontal angles of the anatomical tibial axis compared to the tibial and talar articular surfaces showed no statistically relevant differences with numbers available. The deviation of the assessed preoperative joint axis to the postoperative joint axis was 14.6° ± 7.8.

Conclusion

The present study describes the results of an establishing process of a new PSI technique for TAR. The reliability of guiding block positioning and, thereby, prosthesis placement is sufficient.

Level of Evidence:

Biomechanical study
Safety of hormone replacement therapy in women with a history of cervical adenocarcinoma
Authors: Richardson A , Watson L , Persic M , Phillips A
Published: July 2021

Objectives

Studies investigating the safety of hormone replacement therapy in cervical cancer have predominantly included patients with squamous disease. Pathological studies have identified estrogen receptor positivity in cervical adenocarcinomas. A recent small case-control study suggested a trend towards reduced survival with hormone replacement therapy in cervical adenocarcinomas. Our objective was to determine if hormone replacement therapy use in patients treated for cervical adenocarcinomas is detrimental to survival.

Study design

A retrospective review of all women under the age of 50 with stage 1B-2B cervical adenocarcinomas diagnosed between 1 November 2000 and 24 September 2019. Women were categorised into three groups: ovaries conserved (OVCON); or iatrogenic menopause with (IM-HRT) or without (IM-NOHRT) hormone replacement therapy. Hormone replacement therapy use was defined on an intention to treat basis. Statistical analysis was performed using Kaplan-Meier and Cox proportional hazards methods.

Main outcome measures

Overall (OS), disease specific (DSS) and progression free (PFS) survival.

Results

A total of 58 women (mean age 38.5 ± 6.6) were included in the study of whom 25 (43.1%) had OVCON, 20 (34.4%) had IM-HRT and 13 (22.4%) had IM-NOHRT. No menopause-associated deaths occurred. Although five-year DSS was 73% in IM-NOHRT compared to 95% in IM-HRT and 95% in OVCON, these differences were not statistically significant. Five-year PFS was 68% in IM-NOHRT compared to 90% in IM-HRT and 81% in OVCON but again, these differences were not statistically significant.

Conclusion

In this small study, hormone replacement therapy does not appear to be detrimental to survival in cervical adenocarcinomas. There is a trend towards improved survival with hormone replacement therapy. Larger studies are required to substantiate these findings.
“I Am Not Myself, You See?”: Remediation and Mediatization in the Insta Novels Project
Authors: Shakargy Noa
Published: July 2021

In the summer of 2018, the New York Public Library Instagram page, and Mother—New York City creative company, launched a project named Insta Novels, presenting five canonic literary works in the form of an Instagram Story. Due to its interdisciplinary nature, Insta Novels offers a glimpse into the contradictions that arise when literature and its institutions intersect with social networks, advertising agencies, and digital media. This article explores the Insta Novels project as a case study of how remediation and mediatization serve as useful theoretical concepts, enabling the examination of cultural objects in the new media environment at both the macro and micro levels. A grounded analysis of the project’s stories, articles, and Instagram hashtags revealed four embedded tensions: between literature and technology; eternity and temporality; personal and public; and readers and users.
The Hegemony’s Contest in the South China Sea
Authors: Teixeira Victor Alexandre G.
Published: July 2021

Constantly analyzed in scientific, theoretical, and empirical studies, the “ Asian Mediterranean” region has received renewed attention as a consequence of the rise of China. China’s emergence combines its strong economic dynamic with increased confidence, positioning it as a potential regional hegemony. On that conceptual basis, this study aims to answer whether a power transition has already occurred in the South China Sea and how the process of a regional hegemonic transition took place. Through an examination of the instruments used by the United States and China to exercise power, articulated with the power transition theory, it establishes that a transition in the South China Sea dispute could have already occurred. However, the study disclaims that Beijing’s evolution and sudden change of behavior aim to overthrow the U.S. global leadership but rather intends to reclaim its position of regional hegemony.
Burnout and Engagement at the Northernmost University in the World
Authors: Kaiser Sabine , Richardsen Astrid M. , Martinussen Monica
Published: July 2021

Few studies have looked at the relationship of job characteristics and worker well-being among Norwegian academics. The main purpose of this study was to examine the relationship between job demands, job resources, burnout, and engagement among Norwegian university staff. In total, 236 staff from one university in Norway answered the questionnaire. Hierarchical multiple regression analyses identified job demands as the most important predictors for burnout. Autonomy was the most important job resource in the prediction of engagement and burnout. What constitutes a job resource or a job demand varies from occupation to occupation. The present study adds to the existing literature by examining factors that may protect or harm the individual workers’ health and well-being in a Norwegian university context.
Kuwaiti Students’ Achievements in Mathematics: Findings From the TIMSS Assessments: Reality and Reasons
Authors: Al-Mutawa Farah , Al-Rasheedi Ghazi , Al-Maie Dalal
Published: July 2021

Kuwait, has participated in international TIMSS test for many years, however, there has been little systematic effort to compile and assess changes between genders. This study attempts to look at the results of Kuwaiti students on the TIMSS mathematics assessments in general and according to gender in particular and the views of supervisors on the relatively low performance of Kuwaiti students. The study employed a mixed method approach in which data analysis of test results, IEA-issued documents, and statistics and official reports were used. Two focus group interviews were conducted with a convenience sample of nine educational supervisors from mathematics and science. The results show that the performance of Kuwaiti students in both the fourth and eighth grades was extremely low on the TIMSS mathematics assessments in general and in content areas in particular, since the first participation in 1995, even though the performance of eighth graders showed a slight improvement in 2015 in all areas. The TIMSS results also show that the higher the level of thinking that was assessed, the lower the performance of Kuwaiti students was. The data indicate that throughout all years, Kuwaiti girls outperformed boys, considering the slight improvement especially in 2015, yet both performances lagged behind international norms. Focus group transcript analysis reveals that supervisors perceived that students’ low performance on the TIMSS assessment test is related to a number of reasons as lack of interest in TIMSS test, unfamiliarity with TIMSS questions, and students’ weakness in the Arabic language. The paper concludes the need to systematically evaluate the TIMSS results, and develop interventions and a competent national curriculum in Kuwait.
Conformity Consumer Behavior and External Threats: An Empirical Analysis in China During the COVID-19 Pandemic
Authors: Li Jianan , Jin Xiaotong , Zhao Taiyang , Ma Tiannv
Published: July 2021

Conformity consumer behavior refers to a preference of using the behaviors or expectations of others as a guideline for one’s own consumption patterns. Significant characteristics of conformity consumer behavior have been observed during the COVID-19 pandemic, and it has greatly hindered resource allocation and pandemic management. Nonetheless, the reasons why a public health emergency, exemplified by COVID-19, triggers conformity consumer behavior remain unclear. This study proposes and tests a theoretical framework to explore the psychological mechanisms of conformity consumer behavior during the COVID-19 pandemic. Results indicate that pandemic severity positively affect conformity consumer behavior, sense of fear plays a mediating role between pandemic severity and conformity consumer behavior, and sense of control does not play a moderating role. This implies that fear drives conformity consumer behavior and people may tend to consume in this way when they perceive a strong sense of fear no matter how strong their sense of control is. The conclusion will help managers to guide consumer behavior during social crisis and emergencies.
Retinal vascular findings in patients with COVID-19
Authors: Aydemir Emre , Bayat Alper Halil , Ören Burak , Atesoglu Halil Ibrahim , Şakir Göker Yasin , Özçelik Kazım Çağlar
Published: July 2021

Purpose:

The purpose of this study was to compare the retinal vascular caliber of COVID-19 patients with that of healthy subjects.

Methods:

This was a prospective case–control study. Forty-six patients who had COVID-19 were successfully treated, and 38 age- and gender-matched healthy subjects were enrolled in this study. Fundus photography was taken using fundus fluorescein angiography (FA; Visucam 500; Carl Zeiss Meditec, Jena, Germany). Retinal vascular caliber was analyzed with IVAN, a semi-automated retinal vascular analyzer (Nicole J. Ferrier, College of Engineering, Fundus Photography Reading Center, University of Wisconsin, Madison, WI, USA). Central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and artery–vein ratio (AVR) were compared between groups.

Results:

The mean age was 37.8 ± 9.5 years in the COVID-19 group ( n = 46) and 40 ± 8 years in the control group ( n = 38) ( p = 0.45). The mean CRAE was 181.56 ± 6.40 in the COVID-19 group and 171.29 ± 15.06 in the control group ( p = 0.006). The mean CRVE was 226.34 ± 23.83 in the COVID-19 group and 210.94 ± 22.22 in the control group ( p = 0.044). AVR was 0.81 ± 0.09 in the COVID-19 group and 0.82 ± 0.13 in the control group ( p = 0.712).

Conclusion:

Patients who had COVID-19 have vasodilation in the retinal vascular structure after recovery. As they may be at risk of retinal vascular disease, COVID-19 patients must be followed after recovery.
PEER NGA-East database
Authors: Goulet Christine A , Kishida Tadahiro , Ancheta Timothy D , Cramer Chris H , Darragh Robert B , Silva Walter J , Hashash Youssef MA , Harmon Joseph , Parker Grace A , Stewart Jonathan P , Youngs Robert R
Published: July 2021

This article documents the earthquake ground motion database developed for the NGA-East Project, initiated as part of the Next Generation Attenuation (NGA) research program and led by the Pacific Earthquake Engineering Research Center (PEER). The project was focused on developing a ground motion characterization model (GMC) model for horizontal ground motions for the large region referred to as Central and Eastern North America (CENA). The CENA region covers most of the U.S. and Canada, from the Rocky Mountains to the Atlantic Ocean and is characterized tectonically as a stable continental region (SCR). The ground-motion database includes the two- and three-component ground-motion recordings from numerous selected events relevant to CENA ( M > 2.5, with distances up to 3500 km) that have been recorded since 1976. The final database contains over 27,000 time series from 82 earthquakes and 1271 recording stations. The ground motion database includes uniformly processed time series, 5% damped pseudo-spectral acceleration (PSA) median-component ordinates for 429 periods ranging from 0.01 to 10 s, duration and Arias intensity in 5% increments, and Fourier amplitude spectra for different time windows. Ground motions and metadata for source, path, and site conditions were subjected to quality checks by topical working groups and the ground-motion model (GMM) developers. The NGA-East database constitutes the largest database of processed recorded ground motions in SRCs and is publicly available from the PEER ground-motion database website.
Selection of random vibration theory procedures for the NGA-East project and ground-motion modeling
Authors: Kottke Albert R , Abrahamson Norman A , Boore David M , Bozorgnia Yousef , Goulet Christine A , Hollenback Justin , Kishida Tadahiro , Ktenidou Olga-Joan , Rathje Ellen M , Silva Walter J. , Thompson Eric M , Wang Xiaoyue
Published: July 2021

Traditional ground-motion models (GMMs) are used to compute pseudo-spectral acceleration (PSA) from future earthquakes and are generally developed by regression of PSA using a physics-based functional form. PSA is a relatively simple metric that correlates well with the response of several engineering systems and is a metric commonly used in engineering evaluations; however, characteristics of the PSA calculation make application of scaling factors dependent on the frequency content of the input motion, complicating the development and adaptability of GMMs. By comparison, Fourier amplitude spectrum (FAS) represents ground-motion amplitudes that are completely independent from the amplitudes at other frequencies, making them an attractive alternative for GMM development. Random vibration theory (RVT) predicts the peak response of motion in the time domain based on the FAS and a duration, and thus can be used to relate FAS to PSA. Using RVT to compute the expected peak response in the time domain for given FAS therefore presents a significant advantage that is gaining traction in the GMM field. This article provides recommended RVT procedures relevant to GMM development, which were developed for the Next Generation Attenuation (NGA)-East project. In addition, an orientation-independent FAS metric—called the effective amplitude spectrum (EAS)—is developed for use in conjunction with RVT to preserve the mean power of the corresponding two horizontal components considered in traditional PSA-based modeling (i.e., RotD50). The EAS uses a standardized smoothing approach to provide a practical representation of the FAS for ground-motion modeling, while minimizing the impact on the four RVT properties ( zeroth moment, [Formula: see text]; bandwidth parameter, [Formula: see text]; frequency of zero crossings, [Formula: see text]; and frequency of extrema, [Formula: see text]). Although the recommendations were originally developed for NGA-East, they and the methodology they are based on can be adapted to become portable to other GMM and engineering problems requiring the computation of PSA from FAS.
Autoimmune- and complement-mediated hematologic condition recrudescence following SARS-CoV-2 vaccination
Authors: Portuguese Andrew Jay , Sunga Cassandra , Kruse-Jarres Rebecca , Gernsheimer Terry , Abkowitz Janis
Published: July 2021

A variety of autoimmune disorders have been reported after viral illnesses and specific vaccinations. Cases of de novo immune thrombocytopenia (ITP) have been reported after SARS-CoV-2 vaccination, although its effect on preexisting ITP has not been well characterized. In addition, although COVID-19 has been associated with complement dysregulation, the effect of SARS-CoV-2 vaccination on preexisting complementopathies is poorly understood. We sought to better understand SARS-CoV-2 vaccine-induced recurrence of autoimmune- and complement-mediated hematologic conditions. Three illustrative cases were identified at the University of Washington Medical Center and the Seattle Cancer Care Alliance from January through March 2021. We describe the recrudescence of 2 autoimmune conditions (ITP and acquired von Willebrand Disease [AvWD]/acquired hemophilia A) and 1 complementopathy (paroxysmal nocturnal hemoglobinuria [PNH]). We report the first known case of AvWD/acquired hemophilia A, and describe the first PNH exacerbation in the absence of complement inhibition after SARS-CoV-2 vaccination. Although SARS-CoV-2 vaccine-induced ITP is a known concern, our case clearly depicts how thrombocytopenia in the setting of preexisting ITP can sequentially worsen with each vaccine dose. Based on our experiences and these examples, we provide considerations for how to monitor and assess risk in patients with underlying autoimmune- and complement-mediated hematologic conditions.
Personal protective equipment and doffing procedures in out-of-hospital practice: assessment with a contamination simulation
Authors: Pottier Fabrice , Groizard Charles , Briche Grégory , Haraczaj Nicolas , Garnier Maxime , Loones Vinciane , Ozguler Anna , Baer Michel , Baer Géraldine , Loeb Thomas
Published: July 2021

Background

The use of personal protective equipment (PPE) by emergency medical services (EMS) providers requires specific attention, as it takes place in out-of-hospital unsecured settings. The aim of this study was to evaluate which PPE gown was less contaminating during doffing procedures in an EMS setting.

Six well-trained healthcare worker (HCW) subjects tested 4 different gowns: (1) surgical gowns (SG), (2) full body coveralls (FBC), (3) self-made alternative PPEs (SMP), and (4) non-surgical isolation gowns (NSIG). An invisible tracer was sprayed on the gown after donning each subject. After doffing, each HCW was photographed under UV lights to show areas of fluorescent “contamination” on their clothes. The number, size, and intensity level of contaminated areas were noted, as well as observational deviation from the procedure and doffing time. In addition, the subjects were asked to take a questionnaire about their perception of the level of comfort, ease of doffing, and overall safety for each gown.

Results

Despite a well-trained team of HCW subjects, contamination while doffing was observed with every type of PPE gown, and with each HCW subject. All body areas were contaminated at least once, except the face. Contamination was more frequent while doffing FBCs. On the other hand, the removal of SG was found to be the least contaminating. The mean doffing time was significantly shorter with SG 1:29 and longer with FBC 2:26 (p=0.005).

Conclusion

Results of this study converge towards the selection of surgical gowns over other types of PPE gowns, which met both contamination criteria as well as staff appreciation in this context. Specific attention should be paid to the legs and abdomino-pelvic areas. Additional protection such as protective trousers or aprons could be added.
Construction of a weight-based seed sorting system for the third-generation hybrid rice
Authors: Wu Jianxin , Qiu Shijun , Wang Menglong , Xu Chunjue , Deng Xing Wang , Tang Xiaoyan
Published: July 2021

Background

The third-generation hybrid rice technology can be constructed by transforming a recessive nuclear male sterile (NMS) mutant with a transgenic cassette containing three functional modules: the wild type male fertility gene to restore the fertility of the mutant, the pollen killer gene that specifically kills the pollen grains carrying the transgene, and the red fluorescence protein (RFP) gene to mark the transgenic seed (maintainer). The transgenic plant produces 1:1 NMS seeds and maintainer seeds that can be distinguished by the RFP signal. However, the RFP signals in the partially filled or pathogen-infected maintainer seeds are often too weak to be detected by RFP-based seed sorting machine, resulting in intermingling of the maintainer seeds with NMS seeds.

Results

Here we constructed a weight-based seed sorting system for the third-generation hybrid rice technology by silencing the genes encoding ADP-glucose pyrophosphorylase (AGP) essential for endosperm starch biosynthesis via endosperm-specific expression of artificial microRNAs (amiRNAs). In this system, the NMS seeds have normal endosperm and are heavy, but the maintainer seeds have shrunken endosperms and are light-weighted. The maintainer seeds can be easily and accurately sorted out from the NMS seeds by weight-sorting machines, so pure and fully filled NMS seeds are available.

Conclusions

The weight-based seed sorting system shows obvious advantages over the RFP-based seed sorting system in accuracy, efficiency, and cost for propagation of pure male sterile seeds. These characteristics will significantly increase the value and transgenic safety of the third-generation hybrid rice technology.
Development and validation of a new algorithm model for differential diagnosis between Crohn's disease and intestinal tuberculosis: a combination of laboratory, imaging and endoscopic characteristics
Authors: Lu Yi , Chen Yonghe , Peng Xiang , Yao Jiayin , Zhong Weijie , Li Chujun , Zhi Min
Published: July 2021

Background

Sometimes in clinical practice, it is a great challenge to distinguish Crohn's disease (CD) and intestinal tuberculosis (ITB), we conducted this study to identify simple and useful algorithm for distinguishing them.

Methods

We retrospectively reviewed the medical history of the patients who were diagnosed as ITB or CD. We firstly identified ITB patients, and then the patients diagnosed with CD were matched by age, sex, and admission time in a 1:1 ratio. Patients who admitted between May 1, 2013 and April 30, 2019 were regarded as training cohort, and patients admitted between May 1, 2019 and May 1, 2020 were regarded as validation cohort. We used multivariate analysis to identify the potential variables, and then we used R package rpart to build the classification and regression tree (CART), and validated the newly developed model.

Results

In total, the training cohort included 84 ITB and 84 CD patients, the validation cohort included 22 ITB and 22 CD patients. Multivariate analysis showed that, positive interferon-gamma release assays (IGRAs), ≥ 4 segments involved, longitudinal ulcer, circular ulcer, and aphthous ulcer were confirmed as independent discriminating factors. Using these parameters to build the CART model made an overall accuracy rate was 88.64%, with sensitivity, specificity, NPV, and PPV being 90.91%, 86.36%, 90.48% and 86.96%, respectively.

Conclusion

We developed a simple and novel algorithm model covering laboratory, imaging, and endoscopy parameters with CART to differentiate ITB and CD with good accuracy. Positive IGRAs and circular ulcer were suggestive of ITB, while ≥ 4 segments involved, longitudinal ulcer, and aphthous ulcer were suggestive of CD.
Prevalence of bacterial contamination of touchscreens and posterior surfaces of smartphones owned by healthcare workers: a cross-sectional study
Authors: Kuriyama Akira , Fujii Hiroyuki , Hotta Aki , Asanuma Rina , Irie Hiromasa
Published: July 2021

Background

Mobile phones used by healthcare workers (HCWs) are contaminated with bacteria, but the posterior surface of smartphones has rarely been studied. The aim of this study was to compare the prevalence of microbial contamination of touchscreens and posterior surfaces of smartphones owned by HCWs.

Methods

A cross-sectional study of smartphones used by HCWs employed at two intensive care units at a Japanese tertiary care hospital was performed. Bacteria on each surface of the smartphones were isolated separately. The primary outcomes were the prevalence of microbial contamination on each surface of smartphones and associated bacterial species. Fisher’s exact test was used to compare dichotomous outcomes.

Results

Eighty-four HCWs participated in this study. The touchscreen and posterior surface were contaminated in 27 (32.1%) and 39 (46.4%) smartphones, respectively, indicating that the posterior surface was more frequently contaminated (p = 0.041). Bacillus species and coagulase-negative staphylococci were isolated from each surface of the smartphones.

Conclusions

The posterior surface of a smartphone was more significantly contaminated with bacteria than the touchscreen, regardless of having a cover. Therefore, routine cleaning of the posterior surface of a smartphone is recommended.