bluuebunny/crossref_metadata_2025 huggingface dataset:
Ascertaining the Effect of Social Network on Student’s Mood and Time Management with Respect to Gender in Nigerian Universities.
Authors: Ezugwu Obianuju Assumpta , Nworgu Raymond , Uzo Izuchukwu , Nnamdi Ezeora , Nzeh Royransom
Published: February 2024

One of the most popular pastimes among university students are reading which has an impact on their everyday lives is social networking. Social networking sites have become deeply embedded in the lives of students as a result of their ease of access and technological advancement. This study sought to determine whether a student's number of hours spent online is gender-independent, as well as whether a student's mood (angry/depressed) after utilizing social media is gender-independent. The inquiry was conducted as part of a study of students' responses to questionnaire questions. The results of the chi-square test of independence were used to determine the data's independence across groups. The findings revealed that a student's inclination to become angry or unhappy after utilizing social media is not reliant on their gender. Furthermore, it was observed that the time students’ use on the internet is not gender-specific. The total time the students’ spend on the internet is irrelevant to their gender, according to one study, and the change in a student's mood after utilizing social networking is likewise unrelated to gender.
Kajian Teologis "Yesus Mengutus Berdua-dua" Dalam Pemberitaan Injil Menurut Lukas 10:1-12 : Role Model Penginjilan Masa Kini
Authors: Manurung Well Therfine Renward , Baskoro Paulus Kunto
Published: February 2024

Pengutusan Pemberitaan Injil merupakan pekerjaan Allah sendiri sebagai suatu pernyataan kasih Allah kepada dunia. Suatu pengutusan yang tidak menjadikan kumpulan orang percaya atau Gereja sebagai pusat pemberitaan melainkan sebagai sarana atau alat-Nya. Menggunakan metode kualitatif dengan pendekatan interpretative (interpretative design) dapat menemukan makna dan implementasi frasa “mengutus berdua-dua” dalam suatu Pemberitaan Injil: Pertama, Bahwa peran pengutusan sangat penting di dalam proses awal dari pemberitaan Injil. Tanpa pengutusan, pemberitan Injil tidak akan terjadi. Pengutusan ini harus dengan suatu kerelaan hati di dalam pemberitaan Injil. Pemberitaan Injil merupakan salah satu bentuk keterlibatan Allah di dalam dunia, dengan demikian orang-orang percaya harus mengamati apa yang sedang terjadi di dalam dunia dengan melibatkan Roh Kudus sebagai penolong dan berperan aktif bagi sang pemberita Injil. Kedua, Pemberitaan Injil dilakukan kepada οἶκος (oikos), keluarga, tetapi bukan menjadikannya sebagai tujuan akhir dari Pemberitaan Injil melainkan mempersiapkan οἶκος (oikos) sebagai sarana atau alat-Nya di kemudian hari. Ketiga, Pasca Penginjilan merupakan suatu fase yang sangat penting dan krusial di dalam pertumbuhan dan perkembangan kerohanian οἶκος (oikos), oleh karena ini proses pemberitaan Injil harus tuntas sampai kepada fase ini.
Pemeliharaan Tuhan Atas Umatnya Melalui Gambaran Relasi Antara Gembala Dan Domba Berdasarkan Mazmur 23:1-4 dan Terapannya dalam Pelayanan Pastoral
Authors: Ginting Samuel Sukanta
Published: February 2024

Mazmur adalah kitab kanonik dengan genre puisi, sastra berbentuk puisi merupakan literatur yang sangat umum bagi masyarakat Yahudi. Sastra puisi dalam bentuk sajak nyanyian merupakan bentuk ekspresi dari berbagai emosi dan perasaan antara lain: sukacita, sedih, takut, percaya dan lain-lain. Dalam Mazmur kita dapat melihat ekspresi penulis kitab dalam menggambarkan berbagai macam hal seperti sifat dan karakter Allah dan manusia, bentuk relasi, bentuk ungkapan dalam respon terhadap suatu peristiwa dan harapan serta doa-doa. Penelitian ini bertujuan untuk melihat bahwa Alkitab memberikan gambaran relasi Allah dengan umatNya melalui berbagai hal, salah satunya sebagai Gembala dan Domba-dombaNYa. Melalui pendekatan hermeneutik. Artikel ini menemukan bahwa Daud memberikan deskripsi tentang Allah sebagai pemelihara umatNya serta menunjukkan ekspresi dan responnya untuk tindakan Allah dalam hidupnya.
Kajian Teologis Pengkhotbah 11: 9-10 Berkaitan dengan Prinsip You Only Live Once (YOLO) pada Generasi Muda
Authors: Eunike Meichella Yosepha , Sualang Farel Yosua
Published: February 2024

Principles can be defined as principles, truths that become the basis for thinking, acting, and behaving. Today's young generation also has principles that they hold as a reference in life, one of which is the principle of YOLO which can be defined differently from one another. The problem is that the different understanding of the YOLO principle creates contradictions so that two people with the same principle can have very contradictory ways and achievements in life between the positive and negative sides. Misperceptions in understanding the YOLO principle can affect the moral depravity, mindset, and lifestyle of the younger generation. Therefore, by using a qualitative method with a literal study approach, the researcher will conduct research to find how the YOLO life principle is theologically linked to the book of Ecclesiastes 11: 9-10. At the end of the research, it is found that the YOLO life principle does not contradict the truth of God's word if it is accompanied by accountability to God.
Implikasi Teologis Kepastian Keselamatan dalam Kitab Roma Terhadap Semangat Memberitakan Injil
Authors: Milenia Priskila Penti , Pangngaroan Andreas , Titus Titus
Published: February 2024

Artikel berjudul “Implikasi Teologis Kepastian Keselamatan Dalam Kitab Roma Terhadap Semangat Memberitakan Injil” ini berupaya pengertian mengenai keselamatan adalah hal yang sangat penting untk dipahami dengan bail dan benar.  Sebab tanpa pengertian yang benar mengenai keselamatan maka, tak seorangpun dapat berdiri teguh dalam iman dan dan bergairah dalam memberitakan Injil kepada semua orang. Oleh sebab itu, karya tulis ini diharapkan dapat membantu memberikan pemahaman kepada setiap orang percaya agar dapat mengerti dan yakin tentang kepastian keselamatan yang dimiliki oleh setiap orang percaya dan supaya tetap bersemangat berkontribusi dalam pekerjaan pemberitaan Injil.
Geoteknik Uygulamaların Yapı Bilgi Modellemesi ile IFC Tabanlı Modellenmesi
Authors: ÇINAR Muhammet , ASLAN Halit
Published: February 2024

Kentsel alanlarda şehirleşme ile birlikte barınma, ulaşım, altyapı vb. gibi ihtiyaçların artması ve bunların karşılanması için çözüm modelleri üretilmektedir. Bu tip sorunları etkileyen en önemli özellik farklı mekansal bilgilerin aynı ortamda bütünleşik gösterilmesinin ve çok yönlü bir şekilde ele alınmasını gerektirmektedir. Artan şehirleşmeye paralel olarak gelişen teknoloji, bu tür sorunların üstesinden gelinebilecek yazılım programları ortaya çıkarmıştır. Bu programlar daha çok ya sayısal hesaplama yada geometrik gösterim şeklindedir. Bunları birleştiren ve hepsini tek bir programda gösteren Yapı Bilgi Modelleme (YBM) teknolojisi gelişmiştir. YBM genellikle bina modellene bilmekte ve kent modellerini göstere bilmektedir. Fakat bina modellerinde bina temel elemanları, kent modellerinde geoteknik yapı modelleri ve arazi zemin bilgileri mevcut değildir. Bu makalenin genel amacı kentsel yapılarla sınırlandırılmış bir alanda geoteknik yapıları ve zemin özelliklerini YBM ile modellene bileceğinin göstermektir. YBM yazılımında bina modeli ve diğer modelleri yapabilmek için ölçek kavramı (LoD: Level of Detail) yani ayrıntı düzeyleri ile ifade edilmektedir. Ayrıca her bir ayrıntı öncelikle Endüstri Temel Sınıfları (ETS, IFC) tabanlı formatta oluşturulup daha sonra YBM yazılımları arasında veri akışını sağlamaktadır. Bu çalışmada geoteknik yapıların IFC tabanlı formatta ayrıntı düzeyi oluşturularak üç boyutlu olarak modellenmiştir. Oluşturulan geoteknik model ile beraber bina modellerinde dahil edilmeyen geoteknik yapı elemanlarıda (Fore kazık, iksa yapıları, destek yapıları vb.) YBM dahil edilmiştir. Bu çalışmada oluşturulan model projeyi ilgilendiren yapı elemanlarını tek bir modelde toplamaktadır. Böylece tek bir model yapının kullanım ömrü sırasında ihtiyaç duyulduğu zaman erişimi kolaylıkla sağlanabilmektedir.
Bioassay for bioremediation of degraded agricultural soil using bokashi compost with mountain microorganisms and bell pepper (Capsicum annum) indicator plants
Authors: Paredes Pita Derian Reynaldo , Bravo Moreira Celio Danilo , Bello Moreira Italo Pedro , Mendoza García Gregorio Evaristo , Anchundia Muentes Xavier Enrique , Pérez Bravo Angel Vicente
Published: February 2024

The research aimed to regenerate degraded soils by obtaining samples in the commune of Los Bajos del Pechiche, canton Montecristo, Ecuador. Germination trays and samples of partially degraded and degraded soils as well as fertile soil were used as control for results comparison. Characterization of bokashi with mountain microorganisms was carried out in laboratories using physical, chemical, and microbiological analyses. In a bioassay, bell pepper seedlings were evaluated in treatments of degraded soil mixtures with different combinations of bokashi with mountain microorganisms through response variables: germination at 10 days, number of leaflets in seedlings at 15-30 days, plant height at 30 days and root diameter at 30 days. The doses of bokashi with mountain microorganisms were mixed with degraded soil in the following proportions 25%, 50%, and 75%, respectively. The best treatments were established as 75% degraded and partially degraded soil plus 25% bokashi with mountain microorganisms since the highest values were obtained in the different variables. The laboratory analyses presented bokashi organic fertilizer with mountain microorganisms as an excellent alternative for the regeneration of degraded agricultural soils. The results when compared with the analysis of degraded soil and the levels of FAO concerning the soils using a universal scale demonstrated its efficient alternative for bioremediation. Regarding the economic dimension, it has very high values unfeasible for producers or farmers. Then, the Ecuadorian State should establish promotion policies, including subsidies to make the regeneration of degraded soils a reality and not a utopia.
PENGELOLAAN RETRIBUSI PASAR RAYA SINTANG
Authors: Mochsin Syekh
Published: February 2024

Permasalahan yang akan di kemukan adalah Pengelolaan Retribusi Pasar Raya Sintang padaDinas Perindustrian Perdagangan Koprasi dan Usaha Kecil Menengah Kabupaten Sintang dalampenerapan strategi Komunikasi mengacu kepada peraturan perundang undangan, lebih khusus mengacukepada Peraturan Pemerintah Nomor 39 Tahun 2016 tentang Tatacara Pemungutan Retribusi Daerah.Sumber Daya Manusia yang di tugaskan oleh Kantor DISPRINDAKOP dan UKM Kabupaten Sintang,telah sesuai dengan keadaan di pasar raya Sintang. Sarana Prasaran, Pemerintah Kabupaten Sintangmenyediakan sarana prasarana berupa bangunan Kios yang bertingkat dengan segala pasilitas penunjanglainya. Kesimpulan dalam penelitian ini adalah Pengelolaan Retribusi Pasar Raya Sintang pada DinasPerindustrian Perdagangan Koprasi dan Usaha Kecil Menengah Kabupaten Sintang telah di jalan kanberdasarkan petunjuk teknis dari Undang-undang yang berlaku, Saran meningkatkan Sumber DayaManusia dan Sarana Prasarana penunjang lainnya, juga mampu di manfaatkan Masyarakat KabupatenSintang secara adil.
KEBIJAKAN PELAYANAN PUBLIK DI ERA NEW NORMAL
Authors: Hahury Jhony Fredy
Published: February 2024

Tujuan penelitian ini untuk mendeskripsikan kebijakan pelayanan di era new normalpandemi covid 19 di Desa Sungai Sintang Kecamatan Kayan Hilir Kabupaten Sintang. Subjek penelitianterdiri dari Kepala Desa, sekretaris Desa, dan Kepala Urusan Pemerintahan. Penelitian ini termasukdeskriptif kualitatif dengan teknik pengumpulan data wawancara, observasi dan dokumentasi. Darihasil penelitian dijelaskan bahwa kebijakan pelayanan publik di era new normal sudah dilakukandengan cukup baik sebagai upaya menghadirkan pelayanan publik yang berkualitas dalam rangkamengutamakan kepentingan masyarakat agar memenuhi kebutuhan dasar masyarakat ditengah pandemikcovid 19 baik yang bersifat administrasi maupun pelayanan sosial dengan mengacu kepada prinsipprinsippelayanan seperti kepastian, tepat waktu, partisipatif, dan tanggung jawab. Kebijakan pelayananjuga didukung dengan sumberdaya perangkat desa dan kerjasama dengan semua elemen masyarakatuntuk mencapai tujuan pelayanan yang baik dalam rangka mewujudkan masyarakat desa yang sehatdan mandiri.
Setiap perusahaan selalu memerlu ANALISIS PENERAPAN METODE CONTINOUS (Q) & PERIODE (P) REVIEW DALAM PENGENDALIAN BAHAN BAKU YANG EKONOMIS
Authors: Suseno  , Sumartini Fauzan
Published: February 2024

Pengendalian persediaan dilakukan agar dapat bisa memenuhi kebutuhan suatu konsumen dengan tepat dan biaya yang rendah. PT Ciomas Adisatwa Unit Piat UGM merupakan salah satu perusahaan yang bergerak dibidang pemotongan ayam yang berlokasi Tanjung, Kalitirto, Berbah, Sleman,Yogyakarta, Indonesia. PT Ciomas Adisatwa unit Yogyakarta dipimpin oleh seorang Plant Manager (Manajer Pabrik) di bawah Head of Poultry Processing Division yang bertanggung jawab atas kinerja dan operasi perusahaan. Plant Manager memiliki tanggung jawab secara langsung dengan departemen produksi, gudang, dan juga teknik. Sedangkan garis koordinasi didapatkan oleh departemen Quality Assurance, Personalisa and General Affair (PGA), Marketing, dan Finance and Accounting  yang dipimpin langsung oleh PT Ciomas Adisatwa pusat yang terletak di Krian, Sidoarjo. Keadaan tersebut disebabkan oleh adanya permintaan pasar yang fluktuatif atau tidak stabil sehingga perlu dilakukannya perencanaan persediaan yang lebih baik. Penelitian ini bertujuan untuk mengetahui model persediaan probabilistic yang baik digunakan dalam menentukan kuantitas pemesanan dengan mempertimbangkan total biaya minimal. Perusahaan ini memproduksi 173,178 ekor setiap minggu dengan rata-rata setiap hari memproduksi 28,863 ekor. Penelitian ini bertujuan untuk mengetahui model persediaan probabilistik yang baik digunakan dalam menentukan kuantitas pemesanan dengan mempertimbangkan total biaya minimal. Penelitian dilakukan dengan mempertimbangkan dua metode yaitu metode continuous review system dan periodic review system. . Hasil perhitungan menunjukan Metode Periodic Review Systems sebesar Rp.366.848.499. Sehingga dengan menggunakan Metode Continuous Riview System dapat menghemat biaya persediaan sebesar Rp. 230.735.240, sehingga memberikan penghematan sebesar37%.
A New Approach for Non-Ideal Iris Segmentation Using Fuzzy C-Means Clustering Based on Particle Swarm Optimization
Authors: Rapaka Satish , Pullakura Rajeshkumar , Mandelli Jeevan
Published: February 2024

Segmentation is an important step in iris recognition system because the accuracy of the iris recognition system is affected by the segmentation of the iris. In this paper, an efficient method has been proposed for the segmentation of non-ideal iris images captured under uncooperative conditions. A fuzzy c-means clustering algorithm based on Particle Swarm Optimization (PSO) technique has been employed as a pre-segmentation step in the iris recognition framework. The fuzzy c-means clustering method delimits the iris and eliminates the unwanted portions of an image. The particle swarm optimization technique is incorporated to avoid FCM fall into local minimum. The segmentation accuracy of the proposed method is implemented by considering CASIA v3 Interval and UBIRIS databases. The proposed method is compared with the classical segmentation methods and has an encouraging performance.
Propostas para o ensino na Educação Especial: contribuições do campo acadêmico brasileiro
Authors: Casagrande Rosana de Castro , Oliveira Jáima Pinheiro de
Published: February 2024

Esta pesquisa teve por objetivo sistematizar as principais propostas para o ensino na Educação Especial, no âmbito de seu campo acadêmico, no Brasil. O referencial teórico fundamenta-se em Bourdieu (2004a) e Bourdieu, Chamboredon e Passeron (2007), Hey (2008) e em pesquisas anteriores (Casagrande, 2020, 2021; Casagrande; Mainardes, 2021a, 2021b; Mainardes; Casagrande, 2022) sobre o campo acadêmico da Educação Especial. Caracteriza-se como um estudo de natureza qualitativa, exploratória e bibliográfica. Como resultado, um conjunto de propostas dos agentes do campo foi encontrado e organizado em duas categorias, assim denominadas: 1. Propostas mais amplas: Acessibilidade, Sistema de Suporte Multicamadas, Profissionais de Apoio à Inclusão Escolar; e 2. Propostas mais específicas: Desenho Universal para a Aprendizagem, Ensino Colaborativo, Diferenciação Curricular, Práticas Baseadas em Evidências, Plano Educacional Individualizado, Aprendizagem Cooperativa, Metodologias Ativas e Tecnologia Assistiva. As referidas propostas compõem as chamadas práticas inclusivas inovadoras atualmente recomendadas e que beneficiam a aprendizagem e o desenvolvimento de todos. Os agentes do campo da Educação Especial disponibilizam, por meio de suas pesquisas, diversas produções que, em conjunto, indicam possibilidades para a efetivação da inclusão escolar.
As concessões de empréstimos do BNDES para a educação pública
Authors: Leonardo Francisco Morilhe
Published: February 2024

O escopo do presente trabalho é o de demonstrar que o investimento na área da Educação Pública, vindo do BNDES, permite que haja igualdade, em relação aos métodos e aprendizagem, dos alunos da Escola Particular com os da Estadual, no Ensino Médio, especialmente com o atual formato e com a oferta dos itinerários formativos. Tal ideal se justifica, uma vez que, o ingresso ao Ensino Superior é, a cada ano, preenchido por estudantes oriundos de escolas particulares, principalmente, as mais conceituadas universidades e, o Estado, não proporciona subsídios para que os demais candidatos tenham preparação anterior, ou seja, durante o Ensino Médio, fazendo com que a faculdade seja um caminho para poucos trilharem. Assim, a educação é vislumbrada como crucial, também, para o desenvolvimento social, pois permite com que, ao formar o cidadão, esse terá mais possibilidades de ascensão social e, com isso, reduziria a criminalidade, aumentaria a consciência política, melhorando a democracia, entre outras vantagens sociais. Assim, a atuação do BNDES, que na área educacional tem sido relativamente tímida, pode ser um viés que proporcionaria igualdade entre seus pares, garantindo que seja cumprido, também, os conceitos constitucionais de justiça e igualdade. Logo, será realizado uma revisão de literatura, com base no método dedutivo e no enfoque qualitativo.
El impacto de las reformas educativas en las escuelas normales superiores: una aproximación desde el régimen de políticas
Authors: Gonzaga Rosalina Romero
Published: February 2024

El artículo analiza los cambios en la formación inicial de los docentes de secundaria a partir de tres reformas educativas implementadas en las escuelas normales superiores federales desde los años noventa del siglo pasado hasta el gobierno anterior. El estudio sobre las reformas educativas coloca el acento en los cambios o reconfiguraciones de carácter académico, institucional, organizacional y político que inciden en la preparación inicial de las escuelas normales superiores. Empleando la perspectiva del régimen de política pública y a través de una investigación documental y testimonios de funcionarias federales involucradas en la formación docente, se indaga sobre los cambios y/o permanencias en las escuelas normales superiores, las cuales enfrentaron severas dificultades a fin de atender la creciente demanda de educadores para la educación secundaria, inmersas en una vorágine de decisiones de carácter político. Entre los principales hallazgos, se encuentran que las tres reformas educativas estuvieron ancladas en arreglos político-institucionales que determinaron cambios incrementales y no incrementales, cuyos efectos en el régimen de políticas de la formación desencadenó resultados contraproducentes y perniciosos para las instituciones formadoras.
Egypt's Approach and Initiatives Towards Greener Future: Policy Paper
Authors: Hammad Hagar , Hossam Yara , Mahmoud Mohamed , Fahim Irene S.
Published: February 2024

Climate change as a matter had little attention of public debate, especially in developing countries, until the recent floods caused by the dragon storms in the Middle East and the forest fires in the Mediterranean. Egypt, being strategically crucial in Africa, the Mediterranean, and the Arab world, with strong connections to other countries, aimed to go from promises to action and to discover real answers to climate change by building on past COPs. The administration assumed a more prominent role by coordinating the 27th Conference of the Parties to the United Nations Framework Convention on Climate Change (COP27). People started to realize that this is not something only happening elsewhere in the world. Egypt took the initiative; Challenges have been assessed to reach suitable mitigation approaches, and Egypt's first NDC has been issued to meet the global agenda. Egypt's vision was to accelerate global climate action at the UNFCCC 27th Conference of the Parties (COP 27) through emissions reduction, advanced adaptation, and enhanced flow of appropriate finance, prioritizing developing countries worldwide.
Molecular Docking, ADME and Toxicity Study of Dibenzo-α-pyrone derivatives for GABA and NMDA receptors for their antiepileptic activity
Authors: K. Sawhney Shalini , Narayan Chaitanya , Mishra Achal , Singh Monika , Kaur Avneet
Published: February 2024

The twelve most effective dibenzo-α-pyrone derivatives as anticonvulsant chemicals have been chosen from our earlier study, and their 2D structures have been determined. Using Spartan'14 version 1.1.2, the compounds' 3D structures were generated, optimized, and transferred in PDB format. Molecular docking investigations of effective anticonvulsant drugs utilized the Toshiba Satellite, Dual-core CPU, Windows 8 operating system, and the AutoDockVina of PyRx virtual screening program. PyRx was activated with the flexible docking option to dock the GABAAT enzyme, NMDA, and dibenzo-α-pyrone derivatives (Ligands) into the X, Y, and Z coordinate systems. Some Dibenzo- α -pyrone compounds were studied for their antiepileptic efficacy by molecular docking, absorption, distribution, metabolism, and toxicity. Docking analysis revealed that all the compounds have good binding scores, and SS9 derivative has the highest binding score compared to others in both the targets selected. ADME results revealed that most parameters are within limits, and toxicity analysis suggested that the designed compounds are low in toxicity. This research on molecular docking gives a valued insight for medicinal and pharmaceutical chemists to synthesize more derivatives of designed Dibenzo-α-pyrone compounds as lead for antiepileptic drugs, which would be more effective for managing convulsions.
QSAR of Oxazinanone Derivatives As 11-Β Hydroxysteroid Dehydrogenase Type 1 Inhibitor A Potent Anti Diabetic Agent
Authors: Rawat Shivani , Paliwal Sarvesh , Ale Yogita
Published: February 2024

11-β hydroxysteroid dehydrogenase type 1 is a key enzyme accountable for the interconversion of physiologically inert cortisone to active cortisol thus presents an effective target for the development of pharmacologically active anti diabetic agents focused on manage blood glucose levels, improve insulin sensitivity. The 11β-HSD1 facilitates intracellular cortisol construction that have a disease-causing role in type 2 diabetes and the co-morbidities that it causes. Drugs in habiting the enzyme 11 β-HSD1 offers a potential therapy to lessen the type 2 diabetes. Oxazinanone ring has shown activities as antitumor, antihypertensive, antibacterial, anti-inflammatory, antioxidant and many more. Oxazinanone ring have emerged as potent inhibitors of 11β-HSD1 enzyme. QSAR of Oxazinanone derivatives is performed with a goal of elucidating the key characteristics that cause their anti-diabetic action. QSAR is the most widespread method to ligand-based drug design. It is supposed that structures of the molecules are directly proportional with biological activities, and thus, the biological activities can be altered with any structural changes. The process involves computational or mathematical models to find important correlations between a series of structures and functions. Step wise partial least square, multiple linear regressions, and feed forward neural network were used in a QSAR investigation on enzyme (IC50 nM). The developed models were cross confirmed by the ‘‘leave one out’’ method. The model reveals the significance of steric parameter Verloop B1 (Substitution 1) and Total lipole molecular descriptor.Total lipole bear a resemblance to lipophilicity which is a ratio of the capability of molecules to transfer between oily partition and aqueous partition. These descriptors will have an impact on the design and expansion of novel anti-diabetic 11-hydroxysteroid dehydrogenase type 1 inhibitors.
User Friendly Analytical Method Development and Validation of Salmeterol Xinafoate an Antiasthmatic Drug in Bulk and Formulated Product
Authors: Nalkar Sonal , Sutar Shubhangi , Redkar Mayuresh , More Priyanka , Swami Pooja
Published: February 2024

A simple, precise, accurate, sensitive cheap and selective RP-HPLC method has been developed of salmeterol in bulk and pharmaceutical formulation. The method was carried out on an Inertsil ODS C18 (250 x 4.6mm, packed with 5µ). The maximum absorbance was found to be at 203nm. The Salmeterol xinafoate followed linearity in the concentration range 20 to 70ppm and correlation coefficient was found to be 0.999. Injection volume was selected to be 20µl and the flow rate was fixed at 1.0ml/min. Mobile phase selected with the ratio of methanol and water (60:40 v/v). Run time was selected to be 8min. Retention team was found to be 3.521. The LOD and LOQ were found to be 0.00471 and 0.01429.
Interfacial characterization of poly(pyrrole) films doped with SiO2 nanoparticles and their use as electrosorptive phase of caffeine
Authors: Vidotti Marcio , Valério Tatiana Lima
Published: February 2024

In this work, we show the electrosynthesis of poly(pyrrole) films in the presence of SiO2 nanoparticles to develop a hybrid electrode to study the adsorption properties based on the electrochemical and interfacial features of the modified electrode. The electrodes were carefully characterized using electrochemical techniques such as voltammetry and electrochemical impedance spectroscopy, demonstrating that the inclusion of SiO2 nanoparticles in the PPy films has improved the electroactivity of the conducting polymer, in terms of both kinetics and mass transport. The morphology of the electrodes was also investigated by scanning electron microscopy, demonstrating the high surface achieved by the electrodeposition of either PPy and PPy/nano-SiO2. The system was studied for the electroadsorption of caffeine where the applied potential at the substrate plays a key role in tax of the adsorbed specie, mostly due to the increase of van der Waals interactions, enhanced greatly by the presence of the SiO2 nanoparticles. Adsorption isotherms and modeled equivalent circuits were also adopted to further characterize the interfacial properties of the different electrodes synthesized herein.
Assessing the accuracy of OpenET satellite-based evapotranspiration data to support water resource and land management applications
Authors: Volk John
Published: February 2024

This talk will give an overview of the recent accuracy assessment of the [OpenET](https://etdata.org/) remote sensing evapotranspiration (ET) data production platform. OpenET ET data accuracy was evaluated using direct comparisons with high quality *in situ* ET observations from 152 stations (primarily eddy covariance systems) across the contiguous United States.
Pengaruh E-Service Quality Dan Harga Terhadap Kepuasan Pelanggan Vidio.Com
Authors: Syahputra Syahputra , Fikriansyah Faisal Dava
Published: February 2024

Vidio merupakan platform OTT (Over the Top) penyedia layanan streaming terlengkap di Indonesia. Kesuksesan suatu perusahaan sangat tergantung pada sejauh mana perusahaan dapat memenuhi kepuasan pelanggan. Tingkat kepuasan pelanggan ini dipengaruhi oleh mutu layanan yang diberikan oleh perusahaan. Oleh karena itu Penelitian ini bertujuan untuk mengetahui dan menganalisis bagaimana pengaruh e-service quality dan harga terhadap kepuasan pelanggan Vidio.com serta bagaimana pengaruh e-service quality dan harga secara simultan maupun parsial terhadap kepuasan pelanggan Vidio.com. Metode penelitian yang digunakan dalam penelitian ini merupakan metode kuantitatif. Data dikumpulkan melalui kuesioner yang disebarkan oleh penulis dengan sampel sebanyak 400 responden, Teknik analis data yang digunakan dalam penelitian ini dilakukan dengan menggunakan SPSS 26  (Stastical Package for the Social Sciences). Berdasarkan pengujian hipotesis hasil menunjukan bahwa e-Service Quality memiliki pengaruh positif yang signifikan terhadap kepuasan pelanggan serta harga memiliki pengaruh positif yang signifikan terhadap kepuasan pelanggan Vidio.com.
Pengaruh Pertumbuhan Penjualan, Profitabilitas, Ukuran Perusahaan Terhadap Nilai Perusahaan Dengan Kebijakan Dividen Sebagai Variabel Moderasi
Authors: Asti Areta Emerentiana , Setijaningsi Herlin Tundjung
Published: February 2024

Nilai perusahaan juga dapat dipengaruhi oleh pertumbuhan penjualan, profitabilitas dan ukuran Perusahaan. Tujuan dari penelitian ini adalah untuk memperkirakan nilai perusahaan makanan dan minuman tahun 2018–2022 berdasarkan beberapa kriteria yang mempengaruhi nilai perusahaan. Penelitian ini menggunakan desain penelitian kausal untuk menguji apakah suatu variabel dapat menyebabkan perubahan pada variabel yang lain atau tidak. Populasi yang diamati dalam penelitian ini adalah perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia selama tahun 2018-2022. Hasil penelitian ini menunjukkan bahwa pertumbuhan penjualan tidak berpengaruh terhadap nilai perusahaan pada perusahaan makanan dan minuman yang terdaftar di BEI. Profitabilitas tidak berpengaruh terhadap nilai perusahaan pada perusahaan makanan dan minuman yang terdaftar di BEI. Ukuran Perusahaan tidak berpengaruh terhadap nilai perusahaan pada perusahaan makanan dan minuman yang terdaftar di BEI. Kebijakan dividen memperkuat pengaruh ukuran perusahaan terhadap nilai perusahaan pada perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia pada tahun 2018 sampai dengan tahun 2022.
Pengaruh Leverage, Profitabilitas Dan Likuiditas Terhadap Agresivitas Pajak Dengan Proporsi Komisaris Independen Sebagai Variabel Moderasi
Authors: Sofyan Vania Vashtiany , Ruslim Herman
Published: February 2024

Strategi perusahaan membayarkan pajak dengan meminimalisirkan beban pajak adalah dengan melakukan agresivitas pajak, namun hal ini berdampak dengan kurangnya penerimaan Negara. Tujuan dari penelitian ini adalah manfaat dari evaluasi ulang dengan memasukkan faktor-faktor independen seperti likuiditas, profitabilitas, dan leverage. Studi ini memakai metode deskriptif dengan menganalisis data untuk menggambarkan karakteristik datanya. Data uang digunaakan merupakan data sekunder yang dikumpulkan dari website perusahaan dan website Bursa Efek Indonesia (BEI). Hasil dari penelitian ini menunjukkan bahwaleverage terbukti berdampak signifikan terhadap agresivitas pajak, variabel profitabilitas tidak menunjukkan dampak yang signifikan terhadap agresivitas pajak, likuiditas juga tidak terbukti memiliki dampak yang signifikan terhadap agresivitas pajak, analisis moderasi menunjukkan bahwa proporsi komisaris independen memoderasi pengaruh leverage terhadap agresivitas pajak. Kesimpulan ini memberikan wawasan penting bagi pemangku kepentingan dalam merancang kebijakan perpajakan yang lebih efektif dan berkelanjutan
Dampak Keterlambatan Tunjangan Kinerja Terhadap Kinerja Melalui Motivasi Dan Kepuasan Kerja Pegawai Inspektorat Provinsi Jawa Timur
Authors: Asprianto Asprianto , Setiadi Pompong B. , P Fanny Dwi
Published: February 2024

Penelitian ini bertujuan untuk menginvestigasi dampak keterlambatan tunjangan kinerja terhadap kinerja pegawai Inspektorat Provinsi Jawa Timur melalui motivasi dan kepuasan kerja. Penelitian ini menggunakan pendekatan kuantitatif dengan mengumpulkan data melalui kuesioner yang disebarkan kepada pegawai Inspektorat Provinsi Jawa Timur. Analisis data dilakukan dengan menggunakan teknik regresi untuk mengidentifikasi hubungan antara variabel-variabel yang diteliti. Hasil penelitian menunjukkan bahwa keterlambatan tunjangan kinerja memiliki dampak negatif terhadap motivasi dan kepuasan kerja pegawai Inspektorat. Motivasi dan kepuasan kerja juga terbukti memiliki peran mediator dalam hubungan antara keterlambatan tunjangan kinerja dan kinerja pegawai. Dengan kata lain, keterlambatan tunjangan kinerja tidak hanya secara langsung mempengaruhi kinerja, tetapi juga melalui pengaruhnya terhadap motivasi dan kepuasan kerja.
Peran Adaptasi Teknologi, Penguasaan Teknologi Dalam Meningkatkan Kinerja Karyawan Melalui Fleksibilitas Kerja Di Pt. Media Graha Nusantara Sejahtera
Authors: Siregar Munawir Sajali , Ginting Ginta , Harsasi Meirani
Published: February 2024

Sebagai media informasi berbasis digital, karyawan PT. Media Graha Nusantara Sejahtera memerlukan adaptasi teknologi, penguasaan teknologi dan fleksibilitas dalam bekerja sebagai tuntutan dari era perkembangan digitalisasi, jika karyawan tidak mampu mengikuti era digital maka sebagai perusahaan berbasis digital informasi dengan otomatis akan kalah bersaing oleh pesaing pada perusahaan sejenis. Tujuan penelitian ini untuk menganalisis pengaruh adaptasi teknologi, penguasaan teknologi melalui fleksibilitas kerja terhadap kinerja karyawan di PT. Media Graha Nusantara Sejahtera. Populasi yang dipilih oleh peneliti adalah seluruh karyawan PT. Media Graha Nusantara Sejahtera di posisi Jurnalis dan Reporter yang berjumlah 114 karyawan dengan menggunakan teknik sampling jenuh, sampel dalam penelitian ini berjumlah 114 responden. Variabel independen dalam penelitian ini adalah adaptasi teknologi dan penguasaan teknologi. Variabel moderasi dalam penelitian ini adalah fleksibilitas kerja. Variabel dependen dalam penelitian ini adalah kinerja. Analisis data dalam penelitian ini menggunakan structural equation model. Hasil penelitian menunjukan, adaptasi teknologi berpengaruh positif dan siginifikan terhadap pada fleksbilitas kerja. Penguasaan teknologi berpengaruh positif dan siginifikan terhadap pada fleksbilitas kerja. Adaptasi teknologi berpengaruh positif dan siginifikan terhadap pada kinerja karyawan. Adaptasi teknologi berpengaruh positif dan siginifikan terhadap pada kinerja karyawan. Penguasaan teknologi berpengaruh positif dan siginifikan terhadap pada kinerja karyawan. Fleksibilitas kerja berpengaruh positif dan siginifikan terhadap pada kinerja karyawan pada PT. Media Graha Nusantara.
“Molecular Docking Analysis Of Alpha-Terpineol Against Matrix Metalloproteinases”
Authors: M Nirmal kumar. , Balasubramaniam Dr. A. , Mahesh Dr. P. G.
Published: February 2024

Objectives: The process of wound healing is crucial and complex within the human body, involving various enzymes. Increased concentrations of matrix metalloproteinases (MMPs) at the wound site lead to slowdown in the healing process. Small bioactive compounds produced from natural sources can be used to down-regulate or inhibit these over expressed MMPs. Alpha-terpineol, a mono-terpenoid alcohol with a monocyclic structure, is present in vitex negundo linn leaf, pemus boldus leaf, cajeput oil, coriander oil, and pine oil. It exhibits diverse biological uses, serving as an antioxidant, anticancer, anticonvulsant, antiulcer, anti-inflammatory, antihypertensive, and anti-nonciceptive agent. The work aims to use molecular docking to understand how alpha-terpineol binds to MMPs. Materials and Methods: The MMPs was obtained from RCSB database and the alpha-terpineol was obtained from Pubchem. The Auto Dock software was used to create a molecular docking of alpha-terpineol activity on MMPs. Alpha-Terpineol binds to MMPs receptors. Auto Dock Vina was used to examine the binding box-related files, including a PDBQT file and PYMOL software was then used to analyze the receptor and ligand PDBPT files. Result: Docking tests revealed that alpha-terpineol has a great binding affinity for all four MMPs tested. MMPs 3, 8, and 12 had free binding energies of around -9.1, -10.5, and -9.7kcal/mol, respectively. Conclusion: Therefore, alpha-terpineol can be employed to regulate the function of matrix metalloproteinases and facilitate the process of wound healing.
Collaborative Learning in Computer Labs for Science Education
Authors: J. Mohammed Salih Hakar , Y.  Arif Jahwar , Q. Sabri Shaimaa
Published: February 2024

This study analyzes the use of Computer-Supported Collaborative Learning (CSCL) in computer laboratory settings for secondary school science education. The literature review evaluates the impact of collaborative methods using computer simulations, virtual experiments, and other digital technologies. The search yielded 33 relevant studies, indicating that collaborative conditions outperformed individual laboratory work in computer environments across various measures. Collaborative work in pairs or small teams has been shown to lead to better learning outcomes and expert-like reasoning patterns. Additionally, students have reported finding collaborative computer laboratory work more enjoyable, engaging, and preferable to independent work. The integration of computer-supported collaborative learning (CSCL) into science education presents opportunities to enhance students' learning experiences through interactive and collaborative approaches. This study highlights the importance of student-centered learning design, effective group dynamics, and reliable technology infrastructure for successful CSCL implementation. Additional research is required to identify the best group composition and task design, as well as the implications for effectively implementing computer-supported collaborative learning in science laboratories.
Prevalence of symptomatic deep vein thrombosis (DVT) in patients with temporary double lumen dialysis femoral catheterization-Experience from Multan institute of kidney diseases Multan (MIKD).
Authors: Bashir Khurrum , Anwar Shumaila , Rashid Asghar Muhammad , Saleem Nayyar
Published: February 2024

Objective: The study was conducted in Multan institute of kidney diseases to explore the DVT prevalence after double lumen dialysis femoral catheterization for haemodialysis.

Methodology: Retrospective cross sectional study was conducted in Multan Institute of Kidney Diseases, all double lumen dialysis femoral catheters passed over a period of five years (sep-2017 to sep-2022) were included in study, identified from electronic system of hospital. Except for those with temporary femoral catheters, all patients met the exclusion criteria. SPSS version 25 was used for data analysis and prevalence of DVT was calculated.

RESULTS: Total 6628 patients with a mean age of 48(range 14 -90 years) were catheterized, 4105(61.9%) males and 2523(38.1%) were females, right sided catheters were 1826(27.5%) and 4802(72.5%) patients underwent left sided insertions. Duplex ultrasound was done of all symptomatic 252(3.8%) patients and femoral DVT was confirmed in 174(2.6%) that is 69% of symptomatic patients. The incidence of DVT significantly (3.7 fold) increase at day six and onward. Prevalence of DVT is 2.6% in all catheterized and 69% of symptomatic patients.

Conclusion: Femoral vein remains an important emergency haemodialysis access route. Physicians inserting femoral venous catheters should be aware of the risk of lower extremity DVT from day three and consider performing duplex ultrasound examinations at day five and onwards if it is extremely necessary to be kept in situ for this duration, otherwise attention should be paid gaining access elsewhere at earliest possible opportunity.
Bookshelf
Authors: Greschner Debra
Published: February 2024

Abstract: Debra Greschner reviews three recent publications. Singing Down the Barriers: A Guide to Centering African American Song for Concert Performers by Emery Stephens and Caroline Helton covers the history of African American song, cultural appropriation and other contextual considerations, and suggestions for encouraging performance of this repertoire. Stella Guo Chen and Carlo Alberto Petruzzi offer Word-by-Word Explanation of Italian Opera Librettos in Chinese in seven volumes, covering eight classic operas. Franco Corelli and A Revolution in Singing: Fifty-four Tenors Spanning 200 Years , Volumes II and II by Stefan Zucker are the concluding volumes in a trilogy devoted to the tenor voice.
Experimental Design of the Interaction Effect of Independent Variables on Pineapple (Ananas comosus) Fruit Bromelain Activity
Authors: Nasir-Naeem Khadeejah , Shittu Oluwatosin , Kabiru Adamu , Asojo Oluwatoyin , Akande Sarah
Published: February 2024

Background: Certain factors are known to influence the rate of enzyme activity. It is paramount to study such independent factors to obtain the ideal conditions required to maximize enzyme activity. The time-consuming traditional one-factor-at-a-time (OFAT) approach of evaluating the effect of independent variables on enzyme activity does not consider the interaction effects of the independent variables on dependent responses. Methods: The impact of four independent variables on fruit bromelain activity was evaluated using the complete factorial design of the experiment approach. Results: The highest actual fruit bromelain activity (76.83 U/ml) and predicted activity (74.81 U/ml) were recorded at an optimum pH of 7.5, temperature of 50oC, and incubation period of 10 minutes using azocasein substrate. All tested variables except temperature; the interaction between substrate type and incubation time significantly affected fruit bromelain activity (p < 0.05). Conclusion: The design model analysed the main and interaction effect of the variables on bromelain activity. Therefore, complete factorial design is a better approach than OFAT to determine the effect of independent variables on fruit bromelain activity.
Long Horizon Episodic Decision Making for Cognitively Inspired Robots
Authors:   Department of Brain, Cognition and Computation Lab, IIIT, Hyderabad (Telangana), India., Singh Shweta , Ghatnekar Vedant ,   Department of Mechanical Engineering, MIT WPU, Pune (Maharashtra), India., Katti Sudaman ,   Department of Mechanical Engineering, MIT WPU, Pune (Maharashtra), India.
Published: February 2024

The Human decision-making process works by recollecting past sequences of observations and using them to decide the best possible action in the present. These past sequences of observations are stored in a derived form which only includes important information the brain thinks might be useful in the future, while forgetting the rest. we propose an architecture that tries to mimic the human brain and improve the memory efficiency of transformers by using a modified Transformer XL architecture which uses Automatic Chunking which only attendsto the relevant chunksin the transformer block. On top ofthis,we useForget Span which is technique to remove memories that do not contribute to learning. We also theorize the technique of Similarity based forgetting to remove repetitive memories. We test our model in various tasks that test the abilities required to perform well in a human-robot collaboration scenario.
The Contributory Pension Scheme (CPS) and Sufficiency of Retirement Benefit of the Low-Income Retirees of the Federal Public Service in Nigeria
Authors:   Department of Actuarial Science and Insurance, Lagos State University of Science & Technology, Nigeria, ABERE Omotayo Johncally , Adeola BANJO, Kudirat ,   Department of Actuarial Science and Insurance, Lagos State University of Science & Technology, Nigeria., SAKA Toyin Shafau ,   Department of Actuarial Science and Insurance, Lagos State University of Science & Technology, Nigeria.
Published: February 2024

This study examined the level of sufficient retirement benefit under the contributory pension scheme emanating from the pool of savings contributed that can suffice to provide the minimum needed livelihood. The secondary data of all pension contributions and retirement benefits were retrieved from series of publications of Pen Com from the years 2004 to 2022. The primary data population consists of 1316 retirees. EasyFit 5.6 Professional Software together with the Least Square Model, accumulation and annuity formulae was employed to analyse the secondary data and the responses from the respondents during survey. Arising from the data collected and the analysis carried out using the Consolidated Public Service Salary Structure, the level of comfort of low income retirees who spent 20 to 35 years in active service is nothing to write home about due to insufficient pension benefits as a result of the challenges investigated. The study recommends the implementation of minimum pension derived with requisite modalities of 20 years as the minimum qualifying length of service and only 10-year post retirement subsidy.
Inotropic drugs in septic shock
Authors: Yolsiriwat Nutnicha , Tongyoo Surat
Published: February 2024

Septic shock is a life-threatening condition characterized by a complex underlying mechanism that requires a multidimensional treatment approach. Sepsis-induced cardiomyopathy plays a significant role in the development of multiple organ failure. The focus of this review is to determine the evidence-based data of the commonly used inotropic drugs in the management of septic shock during clinical hypoperfusion and reduced myocardial performance. Current guidelines recommend adding dobutamine to norepinephrine or using epinephrine alone in septic-induced cardiomyopathy, while suggesting against the use of levosimendan. Although dobutamine increases cardiac contractility and heart rate, it also decreases systemic vascular resistance. Epinephrine has a greater potency than dobutamine but does not demonstrate a clinical difference in hemodynamic improvement. Milrinone is preferred for cases involving pulmonary hypertension and right ventricular failure but should be avoided in the presence of renal dysfunction. Levosimendan improves cardiac performance and promotes coronary blood flow, but later evidence mentioned significant arrhythmia compared to other inotropic agents. Due to the narrow therapeutic window of these agents, precise therapeutic targets are crucial.
Fenomena Childfree Berdasarkan Perspektif Hukum Islam Progresif, Pancasila dan Hak Asasi Manusia (HAM)
Authors: Saputra Gusti Rian
Published: February 2024

The childfree phenomenon in normative legal studies is considered an aberration. Islamic law scholars refer to various considerations, ranging from being contrary to nature, not being in accordance with national culture and threatening human civilization. However, in certain cases childfree becomes an alternative because there is an element of unintentional doing it. Call it for health, psychological and other reasons. Strict restrictions on childfree practices when it is done intentionally and views having children as a burden. This research uses qualitative methods and is a library research type. Researchers use a normative legal approach in analyzing data. The analysis technique used is descriptive analytic. Data is taken from various literature such as books, journals, scientific works, official websites and related sources according to the research theme. The results of the research show that according to the progressive Islamic and Pancasila views, childfree is possible for health and psychological reasons. Apart from that, childfree is a person's private choice that cannot be interfered with by other people.