bluuebunny/crossref_metadata_2025 huggingface dataset:
MCUR1 is a prognostic biomarker for ovarian cancer patients
Authors: Fan Liming , Yang Hualiang , Zhang Bo , Ding Hong
Published: August 2021

PURPOSE: To propose MCUR1 gene as a potential biomarker for ovarian cancer prognosis. METHODS: The ovarian cancer patient specimen from TCGA database were analyzed using survival analysis. The immune cell infiltration ratio and checkpoints had also been investigated for different expression group of MCUR1. The function of MCUR1 as a ovarian cancer prognosis biomarker was verified in clinic. RESULTS: The low expression of MCUR1 was associated with the poor prognosis of ovarian cancer patients. The expressions of majority of immune cells and 6 checkpoints in low expression group of MCUR1 were significantly lower than that in high expression group of MCUR1 (P< 0.05). The MCUR1 could be utilized as a prognostic biomarker for ovarian cancer patients in clinic. CONCLUSION: This study has proposed a potential prognostic biomarker for ovarian cancer patients, which offers a beneficial reference for future ovarian cancer administration.
Psychotic Features Among Patients in the Prodromal Stage of Dementia with Lewy Bodies During Longitudinal Observation
Authors: Utsumi Kumiko , Fukatsu Ryo , Hara Yuko , Takamaru Yuji , Yasumura Shuichi
Published: August 2021

Background: Many cases of dementia with Lewy bodies (DLB) present with various psychotic features, including hallucinations, depression, catatonia, and delusions before the onset of cognitive impairment. However, the characteristic features of these psychotic symptoms in prodromal DLB have not been sufficiently described. Objective: To clarify and describe the psychotic features of prodromal DLB before overt cognitive impairment. Methods: The authors analyzed the characteristic psychotic features of prodromal DLB in 21 subjects who developed severe psychotic symptoms without dementia and were diagnosed as DLB after the longitudinal observation period. They were then confirmed to have DLB through indicative and supportive biomarkers of scintigraphy. Results: The psychotic features included a wide variety of symptoms, but convergent to three principal categories: catatonia, delusions-hallucinations, and depression and/or mania. Catatonia was observed in nine cases, five were delusional-hallucinatory, and seven were manic and/or depressive. Seven of the 21 cases exhibited delirium during longitudinal observation. A psychotic state repeatedly appeared without any trigger in 20 of the 21 patients. All subjects developed cognitive impairment at 9.1±4.6 (mean±SD) years after the initial appearance of psychotic symptoms, and subsequently diagnosed with DLB at 71.3±6.1 (mean±SD) years. Conclusion: Elderly patients with psychotic symptoms, such as catatonia, delusion-hallucination, manic and/or depressive features, and delirium without dementia, could indicate symptomatic psychosis or a prodromal stage of any neurocognitive disorder such as DLB. Therefore, further extensive workout (e.g., radioisotope neuroimaging) is required to avoid misdiagnosis.
Prevalence of Low-Value Care and Its Associations with Patient-Centered Outcomes in Dementia
Authors: Platen Moritz , Fleßa Steffen , Rädke Anika , Wucherer Diana , Thyrian Jochen René , Mohr Wiebke , Scharf Annelie , Mühlichen Franka , Hoffmann Wolfgang , Michalowsky Bernhard
Published: August 2021

Background: Low-value care (LvC) is defined as care unlikely to provide a benefit to the patient regarding the patient’s preferences, potential harms, costs, or available alternatives. Avoiding LvC and promoting recommended evidence-based treatments, referred to as high-value care (HvC), could improve patient-reported outcomes for people living with dementia (PwD). Objective: This study aims to determine the prevalence of LvC and HvC in dementia and the associations of LvC and HvC with patients’ quality of life and hospitalization. Methods: The analysis was based on data of the DelpHi trial and included 516 PwD. Dementia-specific guidelines, the “Choosing Wisely” campaign and the PRISCUS list were used to indicate LvC and HvC treatments, resulting in 347 LvC and HvC related recommendations. Of these, 77 recommendations (51 for LvC, 26 for HvC) were measured within the DelpHi-trial and finally used for this analysis. The association of LvC and HvC treatments with PwD health-related quality of life (HRQoL) and hospitalization was assessed using multiple regression models. Results: LvC was highly prevalent in PwD (31%). PwD receiving LvC had a significantly lower quality of life (b = –0.07; 95% CI –0.14 – –0.01) and were significantly more likely to be hospitalized (OR = 2.06; 95% CI 1.26–3.39). Different HvC treatments were associated with both positive and negative changes in HRQoL. Conclusion: LvC could cause adverse outcomes and should be identified as early as possible and tried to be replaced. Future research should examine innovative models of care or treatment pathways supporting the identification and replacement of LvC in dementia.
Alzheimer’s Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus: Linking Functional Connectivity and Clinical Outcome
Authors: Bommarito Giulia , Van De Ville Dimitri , Frisoni Giovanni B. , Garibotto Valentina , Ribaldi Federica , Stampacchia Sara , Assal Frédéric , Allali Gilles , Griffa Alessandra
Published: August 2021

Background: Alzheimer’s disease (AD) pathology impacts the response to treatment in patients with idiopathic normal pressure hydrocephalus (iNPH), possibly through changes in resting-state functional connectivity (rs-FC). Objective: To explore the relationship between cerebrospinal fluid biomarkers of AD and the default mode network (DMN)/hippocampal rs-FC in iNPH patients, based on their outcome after cerebrospinal fluid tap test (CSFTT), and in patients with AD. Methods: Twenty-six iNPH patients (mean age: 79.9±5.9 years; 12 females) underwent MRI and clinical assessment before and after CSFTT and were classified as responders (Resp) or not (NResp), based on the improvement at the timed up and go test and walking speed. Eleven AD patients (mean age: 70.91±5.2 years; 5 females), matched to iNPH for cognitive status, were also included. DMN and hippocampal rs-FC was related to amyloid-β42 and phosphorylated tau (pTau) levels. Results: Lower amyloid-β42 levels were associated with reduced inter- and intra-network rs-FC in NResp, and the interaction between amyloid-β42 and rs-FC was a predictor of outcome after CSFTT. The rs-FC between DMN and salience networks positively correlated to amyloid-β42 levels in both NResp and AD patients. The increase in the inter-network rs-FC after CSFTT was associated with higher pTau and lower amyloid-β42 levels in NResp, and to lower pTau levels in Resp. Conclusion: Amyloid-β42 and pTau impact on rs-FC and its changes after CSFTT in iNPH patients. The interaction between AD biomarkers and rs-FC might explain the responder status in iNPH.
Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer’s Disease Associates with Upregulated Angiopoietin and Downregulated Hypoxia-Inducible Factor
Authors: Skaaraas Gry H.E. Syverstad , Melbye Christoffer , Puchades Maja A. , Leung Doreen Siu Yi , Jacobsen Øyvind , Rao Shreyas B. , Ottersen Ole Petter , Leergaard Trygve B. , Torp Reidun
Published: August 2021

Background: Vascular pathology is a common feature in patients with advanced Alzheimer’s disease, with cerebral amyloid angiopathy (CAA) and microvascular changes commonly observed at autopsies and in genetic mouse models. However, despite a plethora of studies addressing the possible impact of CAA on brain vasculature, results have remained contradictory, showing reduced, unchanged, or even increased capillary densities in human and rodent brains overexpressing amyloid-β in Alzheimer’s disease and Down’s syndrome. Objective: We asked if CAA is associated with changes in angiogenetic factors or receptors and if so, whether this would translate into morphological alterations in pericyte coverage and vessel density. Methods: We utilized the transgenic mice carrying the Arctic (E693G) and Swedish (KM670/6701NL) amyloid precursor protein which develop severe CAA in addition to parenchymal plaques. Results: The main finding of the present study was that CAA in Tg-ArcSwe mice is associated with upregulated angiopoietin and downregulated hypoxia-inducible factor. In the same mice, we combined immunohistochemistry and electron microscopy to quantify the extent of CAA and investigate to which degree vessels associated with amyloid plaques were pathologically affected. We found that despite a severe amount of CAA and alterations in several angiogenetic factors in Tg-ArcSwe mice, this was not translated into significant morphological alterations like changes in pericyte coverage or vessel density. Conclusion: Our data suggest that CAA does not impact vascular density but might affect capillary turnover by causing changes in the expression levels of angiogenetic factors.
A National Survey of Centers for Cognitive Disorders and Dementias in Italy
Authors: Canevelli Marco , Di Pucchio Alessandra , Marzolini Fabrizio , Mayer Flavia , Massari Marco , Salvi Emanuela , Palazzesi Ilaria , Lacorte Eleonora , Bacigalupo Ilaria , Di Fiandra Teresa , Vanacore Nicola
Published: August 2021

Background: Italy has one of the oldest populations in the World and more than one million dementia cases can be estimated at the national level. Objective: The objectives of this national survey include: 1) to report the administrative features and the professional competencies of Centers for Cognitive Disorders and Dementias (CCDDs); 2) to document possible discrepancies by geographic macro-area; and 3) to identify the features of CCDDs that are associated with a better quality in the provision of care. Methods: A survey of Italian CCDDs was conducted between February 2014 and December 2015. A list of CCDDs was obtained through direct interactions with designed delegates from each Italian region. A questionnaire was defined on five sections concerning: 1) location of the CCDD; 2) access to the CCDD; 3) organization of the CCDD; 4) services and treatments provided; and 5) quantitative data on the activities of the CCDD. Results: Overall, 577 out of the 597 eligible CCDDs returned the completed survey questionnaire (response rate: 96.6%): 260 (45.1%) from Northern Italy, 103 (17.8%) from Central Italy, and 214 (37.1%) from Southern-Islands Italy. More than a third of CCDDs were open only once or twice weekly. A median of 450 (IQR: 200–800) patients regularly attended these services. Most patients (70%) were affected by dementia or mild cognitive impairment (19%). Conclusion: We have provided a snapshot of the organization and activities of CCDDs in Italy and documented existing inequalities in the provision of care.
Adaptive defect detection of 3D image of nano CT based on wavelet decomposition
Authors: Zhang Shirong , Wu Lian
Published: August 2021

The defect detection of 3D image of nano CT under different interference has the phenomenon of prominent dislocation. Therefore, an adaptive detection method of 3D image defect of nano CT based on wavelet decomposition is proposed. Analyze the noise of three-dimensional image of nano CT, determine the mixed filtering of image sequence according to the different noise properties, evaluate the mixed filtering of image sequence, complete the preprocessing of three-dimensional image of nano CT, fuse the three-dimensional image of nano CT decomposed by wavelet after preprocessing, enhance the image after decomposition, and realize the defect adaptive detection through the characteristics of wavelet decomposition. The experimental results show that the design method can effectively detect the interference and solve the problems of traditional methods.
GNN-DBSCAN: A new density-based algorithm using grid and the nearest neighbor
Authors: Yihong Li , Yunpeng Wang , Tao Li , Xiaolong Lan , Han Song
Published: August 2021

DBSCAN (density-based spatial clustering of applications with noise) is one of the most widely used density-based clustering algorithms, which can find arbitrary shapes of clusters, determine the number of clusters, and identify noise samples automatically. However, the performance of DBSCAN is significantly limited as it is quite sensitive to the parameters of eps and MinPts. Eps represents the eps-neighborhood and MinPts stands for a minimum number of points. Additionally, a dataset with large variations in densities will probably trap the DBSCAN because its parameters are fixed. In order to overcome these limitations, we propose a new density-clustering algorithm called GNN-DBSCAN which uses an adaptive Grid to divide the dataset and defines local core samples by using the Nearest Neighbor. With the help of grid, the dataset space will be divided into a finite number of cells. After that, the nearest neighbor lying in every filled cell and adjacent filled cells are defined as the local core samples. Then, GNN-DBSCAN obtains global core samples by enhancing and screening local core samples. In this way, our algorithm can identify higher-quality core samples than DBSCAN. Lastly, give these global core samples and use dynamic radius based on k-nearest neighbors to cluster the datasets. Dynamic radius can overcome the problems of DBSCAN caused by its fixed parameter eps. Therefore, our method can perform better on dataset with large variations in densities. Experiments on synthetic and real-world datasets were conducted. The results indicate that the average Adjusted Rand Index (ARI), Normalized Mutual Information (NMI), Adjusted Mutual Information (AMI) and V-measure of our proposed algorithm outperform the existing algorithm DBSCAN, DPC, ADBSCAN, and HDBSCAN.
Identification of Serum Interleukin 6 Levels as a Disease Severity Biomarker in Facioscapulohumeral Muscular Dystrophy
Authors: Gros Marilyn , Nunes Andreia M. , Daoudlarian Douglas , Pini Jonathan , Martinuzzi Emanuela , Barbosa Susana , Ramirez Monique , Puma Angela , Villa Luisa , Cavalli Michele , Grecu Nicolae , Garcia Jérémy , Siciliano Gabriele , Solé Guilhem , Juntas-Morales Raul , Jones Peter L. , Jones Takako , Glaichenhaus Nicolas , Sacconi Sabrina
Published: August 2021

Background: Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common myopathies in adults, displaying a progressive, frequently asymmetric involvement of a typical muscles’ pattern. FSHD is associated with epigenetic derepression of the polymorphic D4Z4 repeat on chromosome 4q, leading to DUX4 retrogene toxic expression in skeletal muscles. Identifying biomarkers that correlate with disease severity would facilitate clinical management and assess potential FSHD therapeutics’ efficacy. Objectives: This study purpose was to analyze serum cytokines to identify potential biomarkers in a large cohort of adult patients with FSHD. Methods: We retrospectively measured the levels of 20 pro-inflammatory and regulatory cytokines in sera from 100 genetically confirmed adult FSHD1 patients. Associations between cytokine concentrations and various clinical scores were investigated. We then measured serum and muscle interleukin 6 (IL-6) levels in a validated FSHD-like mouse model, ranging in severity and DUX4 expression. Results: IL-6 was identified as the only cytokine with a concentration correlating with several clinical severity and functional scores, including Clinical Severity Score, Manual Muscle Testing sum score, Brooke and Vignos scores. Further, FSHD patients displayed overall IL-6 levels more than twice high as control, and patients with milder phenotypes exhibited lower IL-6 serum concentration than those with severe muscular weakness. Lastly, an FSHD-like mouse model analysis confirmed that IL-6 levels positively correlate with disease severity and DUX4 expression. Conclusions: Serum IL-6, therefore, shows promise as a serum biomarker of FSHD severity in a large cohort of FSHD1 adult patients.
Preparation and application of Fe3O4@Acetamidoxanthate as a unique nanosorbent in heavy metal removing
Authors: Mohareri Mohammad Moein , Ghaffari Mehdi , Sattarzadeh Elham , Kakaei Saeed
Published: August 2021

Chelating agents are one of the most important substances in metal extraction, but separation is the main problem in the use of these agents as an adsorbent. After the adsorption of metals by an external magnet, magnetic NPs provide the possibility of easy collecting and isolating the adsorbent nanomaterial for many applications. Given the immense importance of magnetic NPs, there has been widespread interest in accessing the above adsorbent. In the present study, an attempt was made to synthesize acetamido xanthate which was coupled to NPs and has the potential to be used as a nano-adsorbent for the removal of heavy metals. This novel nano sorbent was characterized by scanning electron microscopy (SEM), Fourier transforms infrared (FT-IR), and Nuclear Magnetic Resonance (NMR) spectroscopy. The effect of some parameters such as temperature, time, pH, and the amount of adsorbent on the extraction reaction was investigated. The optimized condition for extraction of cerium was temperature of 30°C, pH = 8, reaction time of 45 minutes using 7.5 mg of the prepared nanosorbent, that in such condition the yield of reaction achieved up to 97%. The prepared adsorbent showed high efficiency in the adsorption of heavy metals specifically.
Pediatric unilateral spatial neglect: A systematic review
Authors: Hart Emerson , Grattan Emily , Woodbury Michelle , Herbert Teri Lynn , Coker-Bolt Patty , Bonilha Heather
Published: August 2021

PURPOSE: Unilateral spatial neglect (USN), an inability to attend to one side of space or one’s body, is commonly reported in adult stroke survivors and is associated with poor outcomes. USN has been reported in pediatric survivors of stroke, but its impact is unclear. The purpose of this systematic review was to summarize and evaluate the literature regarding USN in pediatric stroke survivors. METHODS: PRISMA guidelines, Scopus, CINAHL, PubMed, and other relevant databases were searched with terms including “children”, “stroke”, and “unilateral neglect”, with the ages of participants limited from to birth to 18 years. Data were extracted from studies on the clinical presentation of pediatric USN, the assessment of this condition, treatment options, or USN recovery. RESULTS: A total of 18 articles met inclusion criteria. There were no current prevalence data available. USN presents similarly in children compared to adults. Several different USN assessments were used, however, there were little data regarding treatment options. Furthermore, the data suggest that not all children fully recover. CONCLUSION: This systematic review reveals a lack of quality research to inform the assessment and treatment of children with USN. Although the literature spans decades, there remain no guidelines for standardized assessment or treatment. Similar to adults, paper-and-pencil testing may be less able to identify USN than functional assessments. It is likely that there are children who struggle with undetected USN-related deficits years after their injuries. With a rise of pediatric stroke survivors, there is a pressing need for clinicians to be educated about USN in children, clinical presentations, assessments, and treatments.
Cochlear implant surgery and perioperative dizziness is associated with utricular hyperfunction
Authors: Truong Michelle , Bester Christo , Orimoto Kumiko , Vartanyan Maria , Phyland Debra , MacDougall Hamish , Tari Sylvia , Rousset Alex , Curthoys Ian , O’Leary Stephen
Published: August 2021

BACKGROUND: Dizziness is a common perioperative complication after cochlear implantation (CI). To date, the exact cause behind this phenomenon remains unclear. There is recent evidence to suggest that otolith function, specifically utricular, may be affected shortly after CI surgery, however whether these changes are related to patient symptoms has not yet been investigated. OBJECTIVE: To determine whether CI surgery and perioperative dizziness is associated with changes in utricular function. METHODS: We performed an observational study on patients undergoing routine CI surgery. Utricular function was assessed using the Subjective Visual Vertical (SVV), and perioperative dizziness was determined using a questionnaire. The study followed patients before surgery and then again 1-day, 1-week and 6-weeks after implantation. RESULTS: Forty-one adult CI recipients participated in the study. The SVV deviated away from the operated ear by an average of 2.17° a day after implantation, 0.889° 1 week and –0.25° 6 weeks after surgery. Dizziness contributed to a tilt of 0.5° away from the implanted ear. These deviations were statistically significant. CONCLUSIONS: CI surgery causes utricular hyperfunction in the operated ear that resolves over 6 weeks. SVV tilts were greater in participants experiencing dizziness, suggesting that utricular hyperfunction may contribute to the dizziness.
Analisis Sentimen Masyarakat di Twitter Terkait Pandemi Covid-19
Authors: Yunitasari Yessi , Putera Andi Rahman
Published: August 2021

Media sosial merupakan tempat untuk mencari pertemanan baru serta tempat untuk mengeluarkan pendapat terhadap sesuatu secara bebas. Salah satu media sosial yang banyak digunakan saat ini adalah Twitter. Banyak masyarakat yang memanfaatkan Twitter untuk mengeluarkan pendapat terhadap Pandemi Covid-19 yang terjadi di berbagai negara termasuk di Indonesia. Pandemi Covid-19 atau korona virus di Indonesia diawali dengan temuan penderita penyakit korona virus 2019 (COVID-19) pada 2 Maret 2020 hingga 8 April 2020, telah terkonfirmasi 2.738 kasus positif COVID-19, dengan 221 kasus di antaranya meninggal dan 204 kasus sembuh. Tweet yang dituliskan oleh masyarakat nantinya dapat diklasifikasikan ke dalam sentimen positif maupun sentiment negatif menggunakan analisis sentimen. Hasil dari analisis sentiment kita dapat melihat bagaimana persepsi masyarakat Indonesia terkait pandemi Covid-19 yang terjadi di Indonesia. Proses klasifikasi analisis sentimen akan menggunakan metode naïve bayes. Pengujian sentimen yang dilakukan menggunakan Cross Validation meliputi pengujian 5 Fold dan 10 Fold. Dari masing-masing pengujian tersebut akan dilihat nilai accuracy, presisi dan recall. Hasil Cross Validation pengujian 5 Fold didapatkan hasil dari rata-rata akurasi sebesar 0.756364 (75%). Hasil Cross Validation pengujian 10 Fold didapatkan hasil dari rata-rata akurasi sebesar 0.76 (76%).
DiGA VADEMECUM
Authors: Brönneke Jan B. , Debatin Jörg F. , Hagen Julia , Kircher Philipp , Matthies Henrik
Published: August 2021

Die „App auf Rezept“ ist Realität! Digitale Gesundheitsanwendungen (DiGA) sind in Deutschland zum integralen Bestandteil der gesetzlichen Gesundheitsversorgung geworden. Damit ist ein zentrales Projekt im Rahmen der digitalen Transformation der Medizin in die Umsetzungsphase vorgedrungen. Diese mutige systemische Ergänzung eröffnet Chancen, die jetzt genutzt werden können. Hier leistet das vorliegende Buch seinen Beitrag.

Verfasst vom DiGA-Expertenteam des health innovation hub (hih), handelt es sich um eine schlanke Anleitung für die Entwicklung und Verbreitung Digitaler Gesundheitsanwendungen – von Konzept über Zulassung bis zum erfolgreichen digitalen Produkt. Konzipiert für DiGA-EntwicklerInnen aus Start-ups sowie für bereits etablierte Unternehmen, werden die notwendigen Schritte von der Idee bis zur erfolgreichen Markteinführung beschrieben. Didaktisch klar strukturiert, vermittelt das DiGA VADEMECUM auch wertvolle Einblicke für Finanzierungspartner der EntwicklerInnen aus dem Venture Capital und aus Private-Equity-Bereichen sowie für mögliche Vertriebspartner aus der Pharma- und Medizintechnikbranche. Letztlich ist das DiGA VADEMECUM auch wertvoll für ÄrztInnen und TherapeutInnen, die nicht nur lernen wollen, DiGA sinnvoll zu verschreiben, sondern auch, mit deren digitalem Output im Interesse einer besseren Gesundheitsversorgung ihrer PatientInnen umzugehen.

Das DiGA VADEMECUM – Ein Muss für alle DigitalisiererInnen der Gesundheitsversorgung!
Gastronomi Turizmi Kapsamında Yerel Yiyecek Tüketim Motivasyonlarının Yerli Turistlerin Tekrar Ziyaret Etme Niyetlerine Etkisinin Belirlenmesi: Van Kahvaltısı Örneği
Authors: DAŞDEMİR Ayşegül , MADENCİ Ayse Büşra
Published: August 2021

Hizmet odaklı bir sektör olan turizm sektörü turistler açısından sürekli güncel kalmak durumundadır. Bu durum alternatif turizm çeşitlerine olan ilgiyi artırmaktadır. Gastronomi turizmi dikkat çeken bir alternatif turizm çeşidi olarak kabul edilmekte olup yerel yiyecekler gastronomi turizmi açısından oldukça önemli görülmektedir. Yerel yiyecekler turistlerin yöre halkının kültürünü anlamasında oldukça büyük bir etkendir. Aynı zamanda yerel yiyecekler turistler üzerinde yarattığı motivasyon unsurları ile turistlerin tekrar ziyaret niyetlerini de etkilemektedir. Bu araştırma Van ilinde Van kahvaltısını tadan yerli turistler üzerinde gerçekleştirilmiş ve turistlerin tekrar ziyaret etme niyetlerinin belirlenmesi amaçlanmıştır. Verilerin toplanması için anket tekniği kullanılmış olup veriler sapan analizi ve normallik testinin ardından faktör analizi ve regresyon analizi ile değerlendirilmiştir. Araştırmada tekrar ziyaret niyetine ilişkin yerel yiyecek tüketim motivasyonları “Kültürel Deneyim”, “Heyecan Arayışı”, “Duyusal Çekicilik”, “Bireyler Arası İlişki” ve “Sağlık Beklentisi” olmak üzere 5 boyut altında değerlendirilmiştir. Çalışma sonucunda “Heyecan Arayışı” boyutunun turistlerin uzun dönemde tekrar ziyaret etme niyetleri üzerinde anlamlı bir etkisi olduğu belirlenirken, kısa dönemde tekrar ziyaret etme niyeti üzerinde “Sağlık Beklentisi” boyutunun anlamlı bir etkisi olduğu görülmüştür.
Comprehensive Study of the Physical and Chemical Properties of Phosphorus Sludge and Cottrell Dust
Authors: Nazarbek Ulzhalgas , Besterekov Uilesbek , Abdurazova Perizat , Nazarbekova Saule , Raiymbekov Yerkebulan
Published: August 2021

The article presents the results of physico-chemical research of waste from the phosphorus industry – phosphorus sludge and cottrell dust. The reliability of the experimental results was ensured by the use of generally recognized research methods, as well as reliable physico-chemical and instrumental methods of analysis. The results of the experiment prove the suitability of these types of waste for the production of mineral fertilizers. This, in turn, will make it possible to improve the environmental situation in the southern region of Kazakhstan.
Acute ST-Elevation Myocardial Infarction Associated with Metabolic Syndrome and Its Angiographic Outcome
Authors: Huda Reaz Mahmud , Mozaffor Miliva , Alam Mohammad Ashraful , Hossain Md Delwar
Published: August 2021

Background: Metabolic Syndrome is already one of the major public health problems around the world; it may be more grievous when associated with any cardiac emergency like myocardial infarction (MI).
Objective: To evaluate the association of metabolic syndrome and its angiographic effects on patients with Acute ST-Elevation Myocardial Infarction (acute STEMI).
Methods: This prospective observational study was done in the Department of Cardiology of the National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh, between July and December of 2013. A total 233 patient were selected for data collection; of them 109 were in group I (acute STEMI patients with metabolic syndrome) and 124 in group II (acute STEMI patients without metabolic syndrome). Initial evaluation of the patients was done by history taking and clinical examination. Baseline investigations like ECG, CK(MB), lipid profile, fasting blood sugar, serum creatinine and echocardiography were done. Coronary angiogram (CAG) was done in the Cardiac Cath-Lab facility of the same hospital. Data was analyzed by using SPSS version 16.0. Comparison between groups was done by unpaired t-test, while categorical data was analyzed with Chi-square (c2) test.
Results: In patients with metabolic syndrome (group I), most of them (68.9%) had more than 2 metabolic components out of 4; the combinations were: high TG + low HDL (54.6%), DM + high TG (46.9%), raised BP + high TG (38.5%), DM + low HDL (33.6%), raised BP + low HDL (26.4%) and raised BP and DM ( 24.3%).ECG shows that the inferior wall acute myocardial infarction (MI) was 41.28% and 44.55% in group I and group II respectively, while anterior wall was involved 58.71 % and 55.65% cases respectively, which was not statistically significant. Heart failure was significantly more in patients of group I than group II (46.79% vs. 20.97%; p<0.001). Echocardiography reveals that the left ventricular (LV) ejection fraction (EF) was much less in group I than that of group II (42.8±18.07% vs. 50.4±21.2%; p<0.001). Among the patients who underwent coronary angiogram (CAG), the mean Friesinger score were 9.7±2.5 in group I and 7.1±3.3 in group II (p<0.05); it indicated more chances of severe coronary artery disease and fatality in group I patients.
Conclusion: Acute ST-elevation myocardial infarction patients with metabolic syndrome have much worse angiographic outcome and poor prognosis than those without metabolic syndrome.
J Bngladesh Soc Physiol 2021;16(1): 49-56
Cooperación Empresarial: Un análisis en el sector manufacturero
Authors: Bayona-Pico Jhon Fredy
Published: August 2021

El artículo tiene como propósito ahondar en la cooperación empresarial, analizando las redes de cooperación entre empresas y organizaciones, así como la importancia y el cumplimiento de objetivos en los acuerdos de cooperación empresarial. Para ello, se realiza una revisión de fuentes bibliográficas y se analizan 59 empresas del sector manufacturero ubicadas en Bucaramanga, por medio de la aplicación de la encuesta de Acuerdos de Cooperación Empresarial que medición indicadores de asociatividad en unidades empresariales. Los resultados indican que, aunque la mayoría de las empresas del estudio tienen interés por crear y mantener alianzas estratégicas, es necesario mejorar aspectos como el cumplimiento de objetivos y generar acuerdos de cooperación, para que puedan compartir información y otros recursos tangibles e intangibles con los cuales puedan conseguir beneficios mutuos.
Análisis de la aplicación del impuesto extrafiscal al consumo nacional de bolsas plásticas: Ibagué Tolima
Authors: Cardona Cuéllar Rositter , Sabi Ramírez Evellia , Fajardo María Yenny
Published: August 2021

El presente estudio tuvo como objetivo analizar la medición de la eficiencia en la aplicación del Impuesto Nacional al Consumo de las Bolsas Plásticas INCBP en cuanto al cumplimiento de los objetivos planteados por el legislador, como impuesto extrafiscal en la ciudad de Ibagué, Impuesto creado en la Ley 1819 de 2016, como parte del paquete de impuestos verdes; fue desarrollado bajo el enfoque metodológico cuantitativo, de tipo descriptivo, diseño no experimental y método transversal, en donde se ejecutaron actividades de análisis documental y observación de los establecimientos de comercio. Se logra establecer que, ante la novedad de la norma en materia tributaria, la eficiencia del INCBP, desde el punto de vista extrafiscal y de los entes de control, existen falencias: las cifras de ingresos de este impuesto no representan lo esperado por el Gobierno dado que aún faltan mecanismos para un seguimiento adecuado y oportuno al recaudo del mismo.
Desarrollo de una herramienta de aprendizaje experiencial en el área de Seguridad y Salud en el Trabajo soportada en Realidad Virtual
Authors: Acuña-Rangel Mariana , Lésmez-Peralta Juan Camilo , Paba-Medina Maira Camila , Salas-Chia Luis Miguel
Published: August 2021

La Seguridad y Salud en el Trabajo es una disciplina cuya implementación en las organizaciones ha cobrado cada vez más importancia en los últimos años. Por esta razón, nace la necesidad de encontrar herramientas que soporten el proceso de enseñanza y la transmisión de conocimientos para la vida profesional. Partiendo de la metodología Design Thinking, se genera el proceso de ideación y creación de una herramienta gamificada de aprendizaje experiencial soportada en Realidad Virtual. Como resultado, se obtuvieron cuatro escenarios que simulan la operación de los trabajadores en diferentes sectores productivos. La validación de la herramienta se hizo mediante un instrumento de evaluación de cinco factores, diligenciado por un grupo de prueba que interactuó con el programa. Finalmente, la herramienta presentó aval por parte de los usuarios manifestando que esta es una experiencia educativa que les facilita aprender los conceptos colocándolos en práctica en un ambiente simulado.
Factores psicosociales incidentes en el proceso de desarrollo psicomotor durante la primera infancia. Una revisión sistemática de los avances científicos 2015-2020
Authors: Silva-Fernández Claudia Susana
Published: August 2021

El desarrollo psicomotor en la primera infancia repercute en la adaptación y funcionalidad del individuo, por lo que se convierte en una necesidad conocer los factores que influyen en este proceso. Por tanto, la investigación buscó analizar los avances científicos frente a los factores psicosociales incidentes en el desarrollo psicomotriz infantil de 0 a 6 años de edad, evidenciados en artículos de investigación empírica y de revisión publicados desde 2015 a 2020. El estudio se realizó mediante la técnica de mapeo, analizando 15 de 1086 documentos revisados en: Ebsco, Science Direct, Dialnet y Google Scholar. Se analizaron las características bibliométricas, la metodología y las conclusiones sobre factores psicosociales relacionados al desarrollo psicomotriz infantil. Los resultados sugieren brechas científicas y mayor incidencia de los factores sociales en el desarrollo psicomotriz infantil. Se concluye la necesidad de investigaciones predictivas y con metodología rigurosa, que comprueben la relación entre variables y las teorías que las sustentan.
Proximity tourism: A thematic literature review
Authors: Salmela Tarja , Nevala Henna , Nousiainen Minna , Rantala Outi
Published: August 2021

This literature review aims to build an understanding of the scope and amount of research published on the topic of proximity tourism within the tourism and hospitality literature. In addition to referring to a particular form of tourism that emphasises local destinations, short distances and lower-carbon modes of transportation, proximity tourism builds upon an idea of seeing our proximate, everyday surroundings anew. Despite the currency and relevance of the topic of proximity, the existing literature in tourism and leisure studies on proximity tourism is relevantly scarce. In addition, there is variance in the usage of concepts referring to proximity tourism. With these notions forming the motivation for our study, we conducted a systematic, thematic literature review of international research publications concerning the topic at hand. We identified a considerable potential in this emerging strand of research of proximity tourism to renegotiate tourism, its concepts and future(s). By re-examining the dichotomy between tourist and local; challenging the definition of tourism on the basis of distance as ‘nearness’ and ‘farness’ and; envisioning brave new tourism futures, the reviewed research literature of proximity tourism disrupts the very basic concepts of tourism. The existing literature of proximity (in) tourism is thus able to create space for new conceptualisations within tourism studies that make way for the plurality of tourism futures.
Pengaruh Struktur Modal, Investment Opportunity Set, Ukuran Perusahaan, Return On Asset dan Likuiditas terhadap Kualitas Laba pada Perusahaan Jasa yang Terdaftar di Bursa Efek Indonesia
Authors: Wulandari Bayu , Situmorang Angela Juliananda , Sinaga Donna Valentina , Laia Editha
Published: August 2021

Abstract

The purpose of this study was  to  see  and  test the  effect  of  Capital Structure, Investment Opportunity Set (IOS), Company Size, Return on Asset (ROA) and Liquidity on Earning Quality at Service Companies listed on the IDX (Indonesia Stock Exchange) in 2017-2019. This  research  uses  the  quantitative  descriptive approach. The population obtained was 79 companies  listed  on  the IDX (Indonesia  Stock Exchange) from 2017-2019. Samples were taken  by  using  purposive sampling technique. This technique is also often used  by  other  researchers  because the obtained samples are closer to the research objectives. The obtained samples were 16 companies. The data analysis used various kind of analysys, namely ; the multiple linear analysis, the coefficient of determination test, the classical assumption test, the F test  and  the  t  test. This  result  of  this  study shows that, partially, the Capital Structure,  Investment  Opportunity  Set (IOS),  Company Size, Return on Asset (ROA) and Liquidity did not significantly affect  the  Earning Quality  listed  on  the IDX (Indonesia  Stock  Exchange) in 2017-2019.  Neither, simultaneously, the Capital  Structure,  Investment  Opportunity  Set (IOS),  Company  Size, Return on Asset (ROA) and Liquidity is significant on the  Earning  Quality  at  Service Companies listed on the IDX (Indonesia Stock Exchange) in 2017-2019.

Keywords : Capital Structure, Investment  Opportunity  Set,  Company  Size,  Return on Asset and Liquidity (Current Ratio).
Impacto dos sinais e sintomas de incontinência urinária na qualidade de vida de mulheres praticantes de musculação no Estado de Sergipe
Authors: Sousa Davi Santana , Dantas Anne Caroline de Santana , Neves Natália Santos das , Rodrigues Giancarlos Costa , Santos Melissa Almeida , Tavares Ana Maria Moura , Santos Alan Douglas Bezerra dos , Aquino Vitória Santana de , Melo Lycia Isadora Pereira , Silva Laís Bispo , Santos Yasmin dos , Andrade Fernandes Tavares , Martins Clesimary Evangelista Molina , Aquino Maria Jane das Virgens , Oliveira Daniela Teles de , Santana Licia Santos
Published: August 2021

Introdução: A Incontinência Urinária (IU) é toda perda involuntária de urina, de acordo com a Sociedade Internacional de Continência (ICS). Objetivos: Analisar a prevalência de sinais e sintomas de Incontinência Urinária por esforço em mulheres praticantes de musculação. Metodologia: Estudo transversal do tipo quantitativo, realizado via online por 195 mulheres que praticavam musculação, sendo que dessas apenas 52 foram incluídas no presente estudo, as mesmas responderam a um questionário ao qual colhia informações da vida pessoal para análise de critérios e em seguida o ICIQ-SF para análise da IU no que se refere à frequência, quantidade, interferência na vida pessoal e em que momento perde urina. Resultados: Houve relatos de perdas urinárias em 19,24% das voluntárias. A média de idade foi de 27,11 anos (DP ± 5,61), 21,15% das que apresentaram perda urinária relatam impacto de grave a muito grave e 73,08% disseram não ter nenhum impacto. Prevaleceu 11,54% das mulheres apresentando queixas de atividades que exigem esforço. A perda urinária foi maior naquelas que realizam mais de um tipo de atividade física, ocorrendo em 6 das 10 mulheres que apresentaram incontinência. Conclusão: Pôde-se concluir que, apesar da limitação na amostra, observou-se que os sinais e sintomas de incontinência urinária estavam presentes nas mulheres praticantes de musculação e o impacto que a patologia ocasiona na qualidade de vida destas.
Perfil funcional respiratório de crianças com COVID-19 durante a fase de hospitalização
Authors: Sousa Davi Santana , Brota Jordana Borges , Araujo Rebeca Maria Santos , Costa Aida Carla Santana de Melo
Published: August 2021

A COVID-19 é uma doença derivada do novo coronavírus SARS-CoV-2, que afeta todas as faixas etárias de forma leve, moderada ou grave e que pode requerer cuidados hospitalares. Os principais sinais e sintomas assemelham-se a uma gripe ou resfriado. Nas crianças, é comum a presença de tosse, febre, desconforto respiratório, náuseas, vômitos e ausculta pulmonar com creptos e roncos. Em todo o mundo é encontrada uma menor incidência dos casos em crianças, sendo bastante discutida a justificativa para tal condição. Este trabalho justifica-se pelo período pandêmico atual, o qual suscitou o interesse em investigar o perfil funcional respiratório na população pediátrica do Hospital de Urgência de Sergipe (HUSE), a fim de promover descobertas sobre as manifestações clínicas da COVID-19 em crianças, bem como suas complicações. O objetivo geral desta pesquisa foi estabelecer o perfil funcional respiratório das crianças com COVID-19, admitidas no serviço de pediatria do Hospital de Urgência de Sergipe. Trata-se de um estudo observacional, do tipo analítico, transversal e de campo, com abordagem quantitativa, realizado no período de julho a setembro de 2020. Observou-se que a maioria dos pacientes necessitou de suporte ventilatório, apresentava secreções brônquicas e evoluiu com pneumonia. Não foram encontradas discrepâncias nos achados em relação aos sinais e sintomas apresentados pelos adultos, porém evidenciou-se que a doença acontece em menor incidência e de forma mais branda.
Assistência de enfermeiros da estratégia saúde da família a mulheres climatéricas com sintomas depressivos
Authors: Carvalho Auriane Carvalho Brandão dos , Veras Carla Nayara dos Santos Souza , Brito Hulianna Ximendes Escórcio de , Carvalho Genyvana Criscya Garcia , Rocha Gabriel Mauriz de Moura , Morais Ivonalda Brito de Almeida , Silva Monica do Amaral , Carvalho Geysivana Késsya Garcia , Martins Maysa Memoria
Published: August 2021

As mulheres vêm exercendo diversos papéis na sociedade, ocupando espaços, que outrora, eram exclusivamente dos homens. O acúmulo de responsabilidades, atrelado às alterações hormonais que vivem durante as diferentes etapas da vida como a puberdade, puerpério e climatério culminam em maiores casos de depressão, quando comparado à população masculina. Objetivou-se com este estudo analisar a assistência de enfermeiros da ESF sobre sintomas depressivos em mulheres climatéricas, e como objetivos específicos relatar sobre o atendimento do enfermeiro às mulheres climatéricas com sintomas depressivos e mostrar a importância da assistência do enfermeiro na diferenciação da sintomatologia depressiva e climatérica. O estudo tratou de uma revisão bibliográfica integrativa da literatura. Após leitura minuciosa dos trabalhos encontrados de acordo com os critérios estabelecidos, permaneceram 7 artigos para discussão das categorias temáticas. Viu-se que a assistência é realizada por meio de atividades educacionais, os estudos com enfermeiros mostraram que os mesmos possuem dificuldade em prestar atendimento adequadamente, devido à falta de capacitações nesta área.
Abordagem fonoaudiológica em pacientes com fissura labiopalatal em serviço especializado de alta complexidade na região oeste do Paraná
Authors: Cabral Celina , Lopes Maria Grazielle Paiva Barreto Santana , Oliveira Daniela Lopes de , Baltazar Mariângela Monteiro de Melo
Published: August 2021

Introdução: as fissuras labiopalatinas são as malformações craniofaciais mais frequentemente identificadas em recém-nascidos vivos. De maneira geral, o tratamento das fissuras objetiva corrigi-las cirurgicamente, bem como corrigir os problemas associados, como alterações nas funções da deglutição, mastigação, sucção, audição, fala entre outras consequências que possam surgir. Objetivo: discorrer sobre a atuação e o papel do fonoaudiólogo em equipe multidisciplinar de um centro de reabilitação em anomalias craniofaciais, com enfoque na fissura labiopalatina. Metodologia: trata-se de um relato de experiência produzido a partir das vivências profissionais da equipe de fonoaudiologia em um Centro de atenção e Pesquisa em Anomalias Craniofaciais.  Resultados e discussão: a atuação fonoaudiológica no tratamento especializado das fissuras labiopalatinas é complexa e processual, sendo realizado um acompanhamento longo, no qual os resultados são uma combinação de fatores, como o envolvimento e assiduidade familiar no tratamento, colaboração do paciente, cirurgias e a atuação de cada profissional da equipe. O resultado final do tratamento deve refletir na qualidade de vida e desenvolvimento geral do paciente. Conclusão: entende-se como fundamental a participação do fonoaudiólogo neste processo, com atuação ativa desde o início do tratamento, visando contribuir no desenvolvimento das habilidades comunicativas em geral, bem como detectar possíveis alterações e intervir precocemente.
Qualidade sensorial, nutricional e microbiológica do pão enriquecido com casca de ovo
Authors: Lima Adriene Ribeiro , Costa Juliana Cristina , Amorim Maria Marta Amancio , Rocha Ieda Trindade , Faria Rejane Cássia , Silva Jade Francisco da , Amaral Daniela Almeida do , Gregório Eric Liberato , Delvivo Fernanda Meneghello , Monteze Nayara Mussi
Published: August 2021

O objetivo deste estudo é elaborar um pão caseiro adicionado de farinha de casca de ovo e avaliar a sua qualidade sensorial, nutricional e microbiológica. Foram elaboradas três formulações de pães contendo batata inglesa, óleo de soja, ovos, açúcar cristal, leite de coco verde, farinha de casca de ovo, fermento biológico seco, noz moscada, sal e proporções diferentes de farinha de trigo tradicional e integral. O projeto foi aprovado pelo comitê de ética e pesquisa do Centro Universitário Una de Belo Horizonte. Realizaram-se os testes de aceitabilidade utilizando a escala hedônica e de intenção de compra e de consumo. As análises bromatológicas de proteína, gordura, fibra, cálcio, sódio, umidade e cinzas para elaboração da informação nutricional contendo valor energético, carboidratos, proteínas, gorduras totais, gorduras saturadas, gorduras trans, fibra alimentar, cálcio e sódio foram realizados na amostra de melhor aceitabilidade. Realizaram-se análises microbiológicas de Estafilococos coagulase positiva, Bacillus cereus presuntivo, bolores e leveduras, Escherichia coli e Salmonella spp. A avaliação global das formulações F1, F2 e F3 para os atributos sensoriais obtiveram médias de 7,87±1,09; 8,06±1,28 e 7,74±1,54 e para a intenção de consumo e de compra 5,6±1,30; 5,74±1,67 e 5,48±1,73, respectivamente. O pão se apresentou como um alimento fonte de fibras, baixo teor de sódio e dentro dos padrões microbiológicos para consumo. Concluiu-se que, o pão caseiro adicionado de farinha de casca de ovo isento de lactose obteve ótima aceitação entre os avaliadores e mostrou-se um produto com grande potencial de mercado.
Evaluation of nociception comparing analgesia protocols in cats submitted to elective ovariohisterectomy
Authors: Cruz Mariza Fordellone Rosa , Wenceslau Thais Aparecida , Silva Carolina Miranda da , Zanardo Dafne Fessel , Martins Catarine Del Massa , Souza Raquel Estefania Stringheta de , Silva Nelly Braga , Miasaki Natanne Terumy , Ciboldi Thalissa Fernanda , Massukado Fernanda Mayumi , Rodrigues Diego Resende , Salvador Aline Villas Bôas Manoel , Garcia Giovana , Santos Ana Paula Millet Evangelista dos
Published: August 2021

Felines have a high potential to produce numerous progenies and the most indicated birth control is the ovariohysterectomy surgical procedure. The procedure causes a postoperative pain process, so an effective protocol is needed to assess pain and control it. The study was conducted with 40 females, which were divided into three distinct groups that were given different analgesic protocols, consisting of dipyrone sodium isolated, dipyrone sodium associated with meloxicam and dipyrone sodium associated with tramadol hydrochloride. The objective of the research was to evaluate three analgesic protocols in order to verify the most effective and affordable one. It was observed that the three protocols are viable and effective, however, dipyrone associated with meloxicam showed greater pain control.