bluuebunny/crossref_metadata_2025 huggingface dataset:
Visualization of analytical data to assess the quality of life of the population in large Russian cities
Authors: Karmanova Ekaterina
Published: July 2020

The article describes the technology of using the Foursquare service, the folium library, as well as clustering techniques based on the k-means method for analyzing and assessing the quality of life of the population in large cities, where more than 100 thousand people live. The main indicators of the quality of life of the population of a particular city were selected data on migration flows, housing price, as well as the environmental situation. During the study, a hypothesis was determined about the direct dependence of the outflow of the urban population on the level of high cost of housing, as well as on the level of the ecological situation of a particular city.
As a result of the analysis, a figurative relationship between the cost of housing and the outflow of the urban population was revealed – in cities with a high cost of housing the highest level of population growth. In addition, in cities where there is an outflow of urban population, along with a very low cost of housing, the highest level of environmental pollution was found. Also, clustering of cities using the k-means method showed that in cities with a high cost of housing and a high rate of population growth due to migration flows, a low level of environmental pollution was revealed.
The capabilities of the folium library of the Python programming language made it possible to visually present an interactive map of the country with the level of the ecological situation of cities. According to the author, the results of such studies affect not only the formation of managerial decisions at the federal and regional levels, but also on the assessment of the attractiveness of the city for the life of the local population, as well as people planning to change their place of residence.
Using simulation methods to manage the business continuity of a leasing company
Authors: Guseva Elena , Chusavitina Galina , Povitukhin Sergey
Published: July 2020

In the context of digitalization of all areas of modern organizations, an important role is played by ensuring the continuity of business processes and crisis management. The article discusses the application of the concept of discrete event modeling to study the continuity of business processes of an auto-leasing enterprise, the characteristics of which change randomly. The built simulation model of critical business processes of an auto-leasing organization is described. Simulation experiments using various sets of destructive factors in combination with measures that reduce the vulnerability of the system and prevent threats to the continuity of business processes are described based on these experiments, key indicators of business process efficiency are determined, and critical infrastructure elements are indicated. Simulation parameters are analyzed based on data from simulation experiment reports obtained in the Arena program of Rockwell Software.
Single-Cell RNA Sequencing Reveals mRNA Splice Isoform Switching during Kidney Development
Authors: Wineberg Yishay , Bar-Lev Tali Hana , Futorian Anna , Ben-Haim Nissim , Armon Leah , Ickowicz Debby , Oriel Sarit , Bucris Efrat , Yehuda Yishai , Pode-Shakked Naomi , Gilad Shlomit , Benjamin Sima , Hohenstein Peter , Dekel Benjamin , Urbach Achia , Kalisky Tomer
Published: July 2020

Significance Statement

Kidney development is a complex process involving multiple interacting and transitioning cell types. Drop-seq single-cell technology, which measures gene expression from many thousands of individual cells, has been used to characterize these cellular differentiation changes that underlie organ development. However, the alternative splicing of many genes creates an additional layer of cellular heterogeneity that Drop-seq technology cannot measure. Therefore, in this study, full transcript length single-cell RNA sequencing was used to characterize alternative splicing in the mouse embryonic kidney, with particular attention to the identification of genes that are alternatively spliced during the transition from mesenchymal to epithelial cell states, as well as their splicing regulators. These results improve our understanding of the molecular mechanisms that underlie kidney development.

Background

During mammalian kidney development, nephron progenitors undergo a mesenchymal-to-epithelial transition and eventually differentiate into the various tubular segments of the nephron. Recently, Drop-seq single-cell RNA sequencing technology for measuring gene expression from thousands of individual cells identified the different cell types in the developing kidney. However, that analysis did not include the additional layer of heterogeneity that alternative mRNA splicing creates.

Methods

Full transcript length single-cell RNA sequencing characterized the transcriptomes of 544 individual cells from mouse embryonic kidneys.

Results

Gene expression levels measured with full transcript length single-cell RNA sequencing identified each cell type. Further analysis comprehensively characterized splice isoform switching during the transition between mesenchymal and epithelial cellular states, which is a key transitional process in kidney development. The study also identified several putative splicing regulators, including the genes Esrp1/2 and Rbfox1/2.

Conclusions

Discovery of the sets of genes that are alternatively spliced as the fetal kidney mesenchyme differentiates into tubular epithelium will improve our understanding of the molecular mechanisms that drive kidney development.
Comparison of forward and reverse single-file reciprocation for root canal instrumentation in curved mandibular molar canals - a Micro-CT analysis
Authors: van der Vyver PJ , Vorster M , Paleker F , Vally ZI
Published: July 2020

ABSTRACT To compare (i) canal centering ability and transportation of Primary WaveOne Gold in combination with WaveOne Gold Glider with ProTaper Next X2 in combination with ProGlider using Micro-CT, and (ii) difference in final preparation times between these two preparation groups. Mesiobuccal canals of 50 mandibular first molars were used. Teeth were randomly divided into two preparation groups. Results were analysed using a one-way analysis of variance (ANOVA). Apically, ProGlider/ProTaper Next X2 demonstrated better centering ratio values and lower transportation values compared to WaveOne Gold Glider/Primary WaveOne Gold (p<.05). No differences were found in the mean combined centering ratios and transportation values between groups (p>.05). No statistically significant differences between the canal preparation times were found (p<.06). The combination of ProGlider /ProTaper Next X2 yields better results for transportation and centering ability apically compared to WaveOne Gold Glider in combination with Primary Wave-One Gold. Keywords: Centering ability, ProTaper Next, reciprocation, transportation, WaveOne Gold.
As representações rupestres de biomorfos no Parque Nacional Serra da Capivara - PI: um estudo de caso
Authors: Justamand Michel , De Queiroz Albérico Nogueira , De Oliveira Gabriel Frechiani
Published: July 2020

O presente trabalho tem por finalidade abordar as representações de biomorfos localizados nos sítios arqueológicos no Parque Nacional Serra da Capivara, no estado do Piauí. Este estudo tem por intuito abordar os tipos de representações de biomorfos e analisá-los dentro da arte rupestre na região sudoeste do Piauí, no sentido de obter informações sobre as sociedades pré-coloniais que se estabeleceram no local, sendo considerado o maior enclave de sítios arqueológicos no mundo.
MODERN NEO-PAGANISM IN THE CONTEXT OF MEDIATIZATION OF RELIGION IN UKRAINE
Authors: Koliban Oksana
Published: July 2020

In the article analyzes the features of modern neo-paganism in Ukraine and the level of its organizations representation in the information space of Ukraine. The study analyzed the level of representation of neo-pagan religious communities in secular, multi-religious and mono-religious media. Content monitoring and analysis of the secular media (including electronic media) has shown that religious organizations of neo-pagan orientation rarely appear in the materials of all-Ukrainian editions. They are written about little more often in regional editions, however, as a rule, it is related to pagan rites and customs that have been preserved in Ukraine. Thus, coverage of activities of neo-pagan organizations operating in Ukraine is not represented widespread in the secular electronic media. The low level of representation in the secular media causes a number of reasons, namely: the small number of communities, the absence of press services of organizations, the lack of initiative of believers to give interviews, the lack of financial opportunity to participate in various multi-religious events, etc. However, in a multi-religious projects, particularly in the information platform "Religious Information Service" of Ukraine, rare materials and appeals to life issues of neo- pagan organizations are contained. Thus, we note the lack of widespread coverage of news and materials of neo-pagan organizations and their activities in Ukraine in secular and multi-religious media. Due to above named reasons, theme of mediatization of neo-pagan religion organizations revealed more through activity multi-religious media, ie through their own channels. The feature of joining the information space of Ukraine of neo-pagan organizations is characterized by creating their own channels, filling them with relevant information, based on their view, and lack of overall numerical representation. It can be traced that older religious organizations have their own site, while newly created communities are more oriented to already existing social networks and conduct their informational activities on separately created pages.
Analysis and Realization of CAN Bus Technology in Industrial Conveyors
Authors: Nouby M.
Published: July 2020

Automation industry has undergone a drastic development in recent years. In this busy world human intervention in very high critical industrial processes are compensated by the enormous growth of the automation industries. Due to the advancement there is no need for a person to continuously monitor the system instead by implementing automation through latest technologies, a very high efficient operation of the system is possible. Conveyor system plays an important role in automation for material handlin       g and packaging. For the movement of the material, that is transportation, in any processing, the lack of safety factor leads to many limitation in the automation, due to the unachievable efficiency, that is operational efficiency. For that variable speed drive are used for the purpose of modeling the conveyor belt speed, which is controlled through programmable logic controller. The main objective is to develop an embedded system that will automate the boiler control system by monitoring and controlling the temperature and pressure using the CAN bus communication technology. A PIC microcontroller is used in the project to control the entire operation of the embedded system.
NAS PEGADAS DO CARVÃO: PERFORMANDO UMA PAISAGEM DE CONTAMINAÇÃO AMBIENTAL
Authors: Figueiredo Ruy Cézar Campos
Published: July 2020

ResumoO presente artigo discute a abordagem poética da pesquisa / performance / videoinstalação Carvão Para Seus Olhos Tocarem em relação à paisagem, ressaltando estratégias para lidar com uma questão de contaminação ambiental que acontece nos fluxos de capital e materialidades entre o norte da Colômbia e o Ceará, no nordeste brasileiro. Reflete-se sobre como se tomar vantagem das possibilidades postas pela performance como pesquisa e sua possível relação com tecnologias audiovisuais para dimensionar e promover o contato com paisagens marcadas por questões ambientais envolvendo tanto ambientes quanto pessoas em meio a processos de deslocamento e contaminação.AbstractThis paper discusses the poetical approach on research / performance / videoinstallation the work Coal For Your Eyes to Touch has in relation to landscape, highlighting strategies to deal with a matter of environmental contamination happening in the flows of capital and materiality between the state of La Guajira, north Colombia and the state of Ceara, northeast Brazil. It is reflected how to take advantage of possibilities posed by performance as research and its possible relation with audiovisual technologies to dimension and promote contact with landscapes marked by environmental matters relating to environments and people living processes of displacement and contamination.
A CASA ONDE COM ELA ESTAMOS – ESCRITA, TORÇÃO E VERTIGEM (OU SOBRE QUANDO O AUTOBIOGRÁFICO É ATO BIOGRÁFICO)
Authors: Carreira Luciana Brandão
Published: July 2020

ResumoA aposta de que se trata nesse trabalho visa sustentar que a escrita cumpre funções diferentes, para diferentes sujeitos, em diferentes momentos. É nessa direção que acreditamos que Clarice Lispector fez de seu exercício de escriba o próprio manejo implicado no refazer de seu corpo, enlaçando-se, através do ato de escrever, pulsionalmente a uma língua. Essa perspectiva adotada a respeito da escrita nos permite destacar um importante aspecto a ela relacionado, pois julgamos que vida e obra são vertentes indissociáveis na produção de um estilo, não somente para um escritor, mas para todo artista.RésuméL’objectif de cet article est de maintenir que l’écriture remplit différentes fonctions pour différents sujets et à différentes époques. C’est dans cette direction que nous sommes convaincus que Clarice Lispector s’est confiée à l’exercice de scribe la manipulation même impliquée dans la refonte de son corps, s’entremêlant, à travers l’acte d’écriture, pulsionnément à une langue. Cette perspective de l’écriture nous permet de mettre en évidence un aspect important, car nous pensons que la vie et le travail sont des volets indissociables de la production d’un style, non seulement pour un écrivain, mais pour chaque artiste.
La Citología Exfoliativa por el método individual del lavado vaginal
Authors: Isaza Mejía Gustavo
Published: July 2020

Desde que Papanicolaou y Traut establecieron en forma definitiva la utilidad de la citología exfoliativa como el método ideal para el descubrimiento del carcinoma incipiente de los órganos genitales femeninos y muy especialmente del cérvix uterino, se han ideado numerosos sistemas con el fin de conseguir las muestras más representativas de las secreciones; la pipeta del propio Papanicolaou, la espátula de madera de Ayre para el raspado del cérvix, el tapón vaginal de Nieburgs.
Peritonitis y pelviperitonitis. Manejo y tratamiento en el Servicio de Sépticas del Instituto Materno Infantil "Concepción Villaveces de Acosta" de Bogotá
Authors: Lozano Carrillo Armando
Published: July 2020

1º Se presenta un estudio sobre 20 casos de peritonitis y 9 de Pelviperitonitis tratados en el Servicio de Sépticas del I. M. I. en un período de seis meses sobre un total de 200 pacientes.2º Para el diagnóstico se tuvo en cuenta principalmente la sintomatologia de ingreso, el antecedente de maniobras abortivas y el cuadro clínico.3º La asociación de gérmenes patógenos más frecuente fue la de E. Coli y Estafilococo Albus no Hemolítico.4° El tratamiento se hizo a base de dosis masivas de Penicilina Cristalina 30 a 60 millones al día por vía intravenosa durante 5 a 12 días, asociada a cloranfenicol 3 a 4 grs. al día durante 8 a 10 días por vía intravenosa (6) y cirugía cuando el proceso infeccioso no cedió al tratamiento médico. En todos los casos de Laparotomía se dejaron 500 mgrs. de Rifamicina en la cavidad abdominal, drenes y Penrosse y puntos de tensión en la pared abdominal.5º Se presentaron dos casos de muerte en uno de los cuales el proceso infeccioso estaba asociado a un Síndrome de Kimmestiel Wilson y en el otro a una fístula ileal postoperatoria.
Discurso del Presidente de la Federación Médica Colombiana Dr. Rafael Peralta Cayon en las exequias del Profesor José del Carmen Acosta
Authors: Peralta Cayon Rafael
Published: July 2020

La Federación Médica Colombiana, está angustiadamente consternada ante este injusto año 1966 con sus eternos sacrificios a las proceras, augustas e irreemplazables figuras de la Medicina Colombiana. Hoy le ha llegado el turno al Profesor verdadero, titular, emérito y honorario, doctor JOSE DEL CARMEN ACOSTA VILLAVECES, quien fuera en nuestra Federación su fundador distinguido, su expresidente, su presidente espiritual en todo tiempo, aun después de muerto.
El Urocitograma en Obstetricia
Authors: Duarte Contreras Alberto , Zúñiga Gamboa Ramiro , Palau Manuel José
Published: July 2020

Hemos presentado un estudio somero sobre el urocitograma en obstetricia en 306 pacientes con 1448 extendidos, convencidos de su gran importancia en el manejo de la gestante normal o patológica. Nuestro único fin ha sido demostrar que en cualquier medio se puede utilizar el urocitograma.
Contemporary Data Science for Finance Students: A Comparative Study of Essential Features of Commonly Used Statistical Software
Authors: Viorica Manu Madalina , Vasile Ilie
Published: July 2020

In this paper, we compare some of the essential traits of the software preferred by researchers, students, and professors, such as R or RStudio, or Matlab. In order to fill the gap in the Romanian literature and help finance students in choosing proper tools according to the research purpose, this comparative study aims at bringing a fresh, useful perspective in the relevant literature. In Romania, the use of R was the focus of several international conferences on official statistics held in Bucharest, and others having business excellence, innovation, and sustainability as purpose, while Eviews is recommended and taught by the Romanian professors. At this time, at a global scale, R programming language is considered the lingua franca of data science, as common statistical software used both in corporations and academia. In this paper, I analyze the basic features of such software, with the purpose of application in finance.
KOMPLEKSNOST I INKLUZIVNOST SOCIJALNOG IDENTITETA KAO POSREDNICI UTICAJA SOCIJALNE NORME NA ODNOS PREMA NEPRIPADNIČKIM GRUPAMA
Authors: Đorđević Ana
Published: July 2020

U ovoj studiji ispitivali smo prediktivnu moć kompleksnosti i inkluzivnosti socijalnog identiteta u odnosu na stavove prema nepripadničkim grupama, uticaj socijalne norme na kompleksnost i inkluzivnost identiteta, kao i medijatorsku ulogu kompleksnosti i inkluzivnosti u odnosu između socijalne norme i stavova prema drugim grupama. Kompleksnost socijalnog identiteta referiše na subjektivni doživljaj preklapanja sopstvenih grupa, dok inkluzivnost predstavlja meru identifikacije sa ljudima na osnovu socijalnih identiteta. Korišćene su nacionalna (građani Srbije/građani Hrvatske), etnička (Srbi/Hrvati) i religijska grupa (pravoslavci/katolici). Uzorak je činilo 153 ljudi (36% muškaraca) prosečnog uzrasta 26 godina. Rezultati pokazuju da je inkluzivnost, ali ne i kompleksnost, snažan prediktor prihvatanja pripadnika drugih grupa, merenog preko termometra osećanja i skale socijalne distance. U eksperimentalnoj fazi studije, pokušali smo da ispitanicima sa manjom spremnošću za prihvatanje pripadnika drugih grupa (N = 40) prezentovanjem grupne norme promenimo stavove i ispitamo da li u tome posreduje promena u doživljaju granica svojih socijalnih identiteta (kompleksnost i inkluzivnost). Izlaganje deskriptivnoj grupnoj normi, datoj u vidu fiktivnog izveštaja sa naučnog istraživanja, dovelo je do većeg prihvatanja tuđih grupa, ali i neočekivano smanjilo kompleksnost socijalnog identiteta. Moguće je da je način na koji smo plasirali informaciju o grupnoj normi narušio osećaj jedinstvenosti grupe ispitanika, te su oni pribegavali jednostavnijim strukturama identiteta. Predložili smo da se u budućim istraživanjima koriste intervencije koje bi specifičnije ciljale na promene u identitetskoj kompleksnosti i inkluzivnosti, kao i da se porede iste intervencije na različitim grupama.
Modeling Epidemics as First-order Systems – COVID-19 Example
Authors: Abusam Abdallah
Published: July 2020

The semi-logarithmic plot of the cumulative number of cases of epidemics resembles the response of a first-order systems for a step load. This similarity was utilized to develop a first order model that can be used for extracting information about the dynamics of infectious disease epidemics. The developed model was validated using COVID-19 data of China. It was also heuristically fitted to other 13 countries. Obtained results indicated that the model can reliably forecasts the number of infected person, epidemic growth speed towards steady-state condition (process time constant, T), and time to reach steady-state condition (4T). The developed model will help public health authorities in developing more effective control strategies of epidemics.
Filsafat Sufistis Suhrawardi Al-Maqtul
Authors: Mufid Fathul
Published: July 2020

Suhrawardi built his philosophical thinking with the spirit of combining “intuition-mystical vision” with “rational-philosophical vision”. The combination of “intuition-mystic and rational-philosophical vision” is known as "hikmah al-Isyraq". The concept of Wisdom al-Isyraq is the second school of thought in Islamic Philosophy. This paper is a study of Suhrawardi's Sufistic philosophy with a historical and philosophical approach. The historical approach is used to review the thought settings that influence Suhrawardi's thoughts from the historical point of view of previous Islamic thought. In addition, a philosophical approach is also used to analyze documentary data in a fundamental, integral, and systematic manner with the descriptive-analysis method. The purpose of this paper is to trace the basic thinking of the concept of "Hikmatul Isyraq" Suhrawardi from the point of view of Sufistic philosophy. The findings of this study indicate that there are five sources of Isyraq Suhrawardi's thoughts: first, Sufism thoughts, especially al-Hallaj and al-Ghazali. Second, the thinking of Paripatetik Islamic Philosophy, especially Ibn Sina, which is considered important to understand Isyraqi's teachings. Third, philosophical thinking before Islam, namely the flow of Pytagoras, Platonism, and Hermenism. Fourth, the thought (wisdom) of ancient Persia which he considered to be the direct heir of the wisdom of the Prophet Idris As. (Hermes). Fifth, the teachings of Zoroaster, especially in using the symbol "light" and "darkness".
Konsep Sufistik “Martabat Tujuh” Sebagai Model Islamisasi Masyarakat Buton
Authors: Malik Rif'atul Khoiriah
Published: July 2020

The article aims to examine the traces of the spread of Islam in Buton in terms of an analysis of the process of islamization in the archipelago. One of the processes of Islamization in Buton is related to the concept of "Martabat Tujuh." The concept of “Martabat Tujuh” which is considered to be the teachings of Sufism is a forerunner to the system of the Sultanate of Buton in the past. 138-1584) Sultan Murhum is called the title of the Sultanate of Qa'im ad-din, historical approach method is part of the achievement of the results of this research.The data that has been collected is then analyzed using descriptive analysis especially in order to describe the contextualization of the concept of "Martabat Tujuh" with The purpose of this research is to review the history of Islam that developed in Buton as one of the processes of Islamization in the archipelago.The results of this study indicate that a critical review of Islamic civilization in the past needs to be an example so that Islam in the modern era still exists especially as an alternative settlement problem of society.

 

 

 

 
Peran Ruqyah Syar'iyyah dalam Terapi Psikospiritual: Analisis terhadap Model Pengobatan Kecanduan Narkoba
Authors: Mohd Amin Mohd Zohdi , Abidin Mohd Saiful Amri Zainal
Published: July 2020

A Psychospiritual therapy was found to be effective in the treatment of drug addiction carried out in government and private care centers. Psychospiritual therapy itself is a psychotherapy that uses a spiritual approach in its application. Islamic Psychospiritual Therapy with the concept of Tazkiah al-Nafs is incomplete without Ruqyah Syar'iyyah aspects. The main purpose of this research is to investigate the method of implementing Ruqyah Syar'iyyah elements in the context of drug addiction recovery. Thus, qualitative research was carried out in five treatment centers for drug addicts selected using an Islamic psychospiritual approach. Data obtained through text analysis, interviews and observations. The study found that the Ruqyah Syar'iyyah aspect was carried out in the Psychospiritual treatment process in the recovery of drug addicts. However, he was not given serious attention from the point of consciousness, understanding and appreciation. As a result, trainers are less concerned with training after completing the treatment period at the drug rehabilitation center and ignoring it. After that the coach is easy to return to drug addiction. In addition, research suggests that some elements of Ruqyah Syar'iyyah and their appreciation be added and applied systematically through the process of riyadah al-Nafs and Muraqabah al-Nafs.
Clinical Efficacy of First and Second Series of Peptide Receptor Radionuclide Therapy in Patients With Neuroendocrine Neoplasm: A Cohort Study
Authors: Zacho Michala Danielle , Iversen P. , Villadsen G. E. , Baun S. MD , Arveschoug A.K. , Grønbæk H. , Dam G.
Published: July 2020

Background

Peptide receptor radionuclide therapy (PRRT) is an established treatment for metastatic neuroendocrine neoplasms (NEN) with positive effects on progression free (PFS) and overall survival (OS), but only limited data exists for the effect of multiple series of PRRT. The aim of this study was to investigate PFS and OS in NEN patients treated with multiple series of PRRT conforming to the ENETS treatment protocol.
Methods

We included all patients with gastrointestinal (GI), pancreatic and bronchopulmonary (BP) NEN treated with PRRT from 2008 to 2018. We used Kaplan-Meier estimation to evaluate PFS and OS with subgroup analysis of primary tumor, Ki67-index, type of radioisotope and number of PRRT series.
Results

Of 150 patients, 133 patients were included with female/male 61/72, median age 70 (interquartile range 64–76) years. GI-NEN comprised 62%, pancreatic 23% and BP 11%. Median Ki67-index was 5%. After first PRRT G1- and G2-tumors had PFS of 25 and 22 months, compared to 11 months in G3-NENs (p < 0.05) and PFS was longer in G1/G2 GI-NENs than BP-NEN (30 vs. 12 months, p < 0.05). After retreatment with a second series of PRRT, the overall PFS (G1-G3) was 19 months, with G1- and G2-tumors having the highest PFS of 19 and 22 months, respectively. Overall, the GI and BP tumors had an OS of 54 and 51 months.
Conclusions

PRRT is an effective therapy with long-term PFS and OS, especially in G1 and G2 NENs, and with better prognosis in GI-NEN compared with BP-NENs. OS and PFS was shorter after the second series of PRRT compared with the first, however results were still encouraging.
Early decarbonisation of the European energy system pays off
Authors: Victoria Marta , Zhu Kun , Brown Tom , Andresen Gorm , Greiner Martin
Published: July 2020

For a given carbon budget over several decades, different transformation rates for the energy system yield starkly different results. We consider a budget of 33 GtCO2 for the cumulative carbon dioxide emissions from the European electricity, heating, and transport sectors between 2020 and 2050, which represents Europe's contribution to the Paris Agreement. We have found that following an early and steady path in which emissions are strongly reduced in the first decade is more cost-effective than following a late and rapid path in which low initial reduction targets quickly deplete the carbon budget and require a sharp reduction later. Costs of solar photovoltaic, onshore and offshore wind have plummeted during the last decade. We found that those technologies can become the cornerstone of a fully decarbonised energy system and that installation rates similar to historical maxima are required to achieve timely decarbonization. Key to those results is a proper representation of existing balancing strategies through an open, hourly-resolved, networked model of the sector-coupled European energy system.
The demand for elderly care services and anticipated living arrangements among the oldest-old in China based on the Andersen model
Authors: Zeng Yanbing , Que Shuang , Lin Chenxi , Fang Ya
Published: July 2020

Background: In China, the issues arising from an aging population are becoming increasingly serious, so research on elderly health has become a topic of discussion. However, few studies have focused on the oldest-old with regards to their existing demand for elderly care services and anticipated living arrangements. Methods: The data of 4738 participants aged ≥80 years were extracted from the Chinese Longitudinal Health Longevity Survey (CLHLS) carried out in 2014. Using the Andersen model as the analysis framework, a multiple logistic regression was used to analyze the relationship between anticipated use of social services and intended residence and influencing factors. Odds ratios (ORs) were calculated to indicate the relationship between the influencing factors and the dependent variables.Results: From the descriptive analysis results, it is found that oldest-old showed high anticipated needs for care services, such as home visits (83.5%), health education (76.4%). And there exists a huge imbalance between supply and demand for aged care services. Moreover, living with children is still the most important way of providing for the oldest-old (44.4% in urban, 55.6% in rural). The multivariate regression results showed that the demand for elderly care services and anticipated living arrangements among the oldest-old in China are influenced by predisposing factors, enabling factors, and need factors (P<0.05). The oldest-old who are older, without housing property rights, childless, and ADL-restricted are more tend to live in long-term care institutions (ORs>1, P<0.05). Conclusions: The most vital needs of the oldest-old are home visits, health education, and spiritual comfort. There is a huge imbalance between supply and demand. Moreover, living with children is still the most important way of providing for the oldest-old. Demand for elderly care services and anticipated living arrangements are influenced by predisposing, enabling and need factors. Although the family plays an essential role in the healthcare of the oldest-old, the traditional pension model no longer meets the multi-level and diversified healthcare service needs of the oldest-old due to the rapidly aging Chinese population, which requires countermeasures from policy makers.
Expression of Spindle and Kinetochore-related Complex Subunit 3 is Associate With the Progression and Prognosis of Hepatocellular Carcinoma and Pancreatic Adenocarcinoma
Authors: Su Kuiwei , Huang Yu , Xie Shufang , Yang Chen , Ru Guoqing , He Xianglei , Chen Wanyuan , Pan Hongying , Cheng Gang , Wang Shibing
Published: July 2020

Background

Several studies have shown that Spindle and Kinetochore-related Complex Subunit 3 (SKA3) is closely related to the diagnosis and prognosis of various cancers. SKA3 plays a vital role in mitosis, but the mechanism underlying its action in tumors has not been fully elucidated.
Methods

Two separate microarrays of pancreatic adenocarcinoma (PAAD) and hepatocellular carcinoma (HCC) samples were downloaded from the Gene Expression Omnibus (GEO) and analyzed using R software. Tissues from 203 HCC and 321 PAAD patients were used for tissue microarray (TMA) construction and immunohistochemical staining for scoring. Kaplan-Meier estimators were used to determine their clinical relevance. Finally, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomics (KEGG) were used for analyzed rich pathways of SKA3 to understand gene function further.
Results

Contrary to the results obtained from the GEO database, HCC and PAAD tumor tissues exhibited significantly lower expression of SKA3 compared to the adjacent tissues (P < 0.001). The size of HCC tumor and Edmondson grade were statistically correlated with SKA3 expression (P < 0.05). No correlation was observed between the levels of SKA3 expression and vascular invasion, metastasis, or lymphatic infiltration in HCC patients. Moreover, factors related to decreases of SKA3 in PAAD could similarly not be found. Kaplan-Meier survival curves indicated that SKA3 upregulation in HCC was significantly associated with better prognosis (P = 0.016). In contrast, low levels of SKA3 were related to poor prognosis of PAAD patients (P = 0.026). Enrichment analysis of GO and KEGG pathways showed that SKA3 gene was closely related to cell cycle pathways.
Conclusions

The results of the present study indicate that SKA3 expression can serve as a diagnostic and prognostic biomarker for HCC and PAAD. However, there is a need to conduct further studies to verify these findings, especially the prognostic role of SKA3 in PAAD.
Association of cardiometabolic multimorbidity pattern with dietary factors among adults in South Korea
Authors: Jeong Dawoon , Kim Jieun , Lee Hansongyi , Kim Do-Yeon , Lim Hyunjung
Published: July 2020

Backgrounds

Globally, cardiometabolic multimorbidity pattern (CMP) is a complexed chronic health status which shorter the life expectancy compared with single disease in adults. We aimed to identify multimorbidity patterns in Korean adults to clarify the associations between dietary factors and CMP.

Methods

Nationally representative data for 9,011 Korean adults aged 19-64 years are obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) from 2013-2015. Multimorbidity patterns for CMP, inflammatory disease, cancer and other disease pattern were identified by exploratory factor analysis. Dietary factors including food, nutrient intake and diet habits were evaluated. Multivariable-adjusted logistic regression models examined the associations between dietary factors and CMP.

Results

More than half of the multimorbidity pattern was CMP (n=4,907, 54.5%); CMP subjects were more likely to be older, male, less educated, lower income, laborers, smokers, and high-risk consumers of alcohol than those of non-CMP subjects. A higher intake of calcium (OR= 0.809, 95% CI= 0.691-0.945), potassium (OR= 0.838, 95% CI= 0.704-0.998), and fruits (OR= 0.841, 95% CI= 0.736-0.960) were inversely associated with the prevalence of CMP while the consumption of irregular meals (OR=1.164, 95% CI= 1.034-1.312) and skipping breakfast (OR=1.279, 95% CI= 1.078-1.518) were associated with a 16% and 28% higher likelihood of CMP, respectively.

Conclusions

CMP accounts for more than half of the multimorbidity patterns in Korean population, and lower intake of calcium, potassium, fruits, and skipping meals might have strong associations with CMP.
Metabonomics Study on the Effect of Traditional Chinese Medicines Feed Addition on Growth Performance and Serum Metabolic Profile of Juvenile Chinese Softshell Turtle (Pelodiscus Sinensis Wiegmann) using UPLC–Triple /TOF–MS Analysis
Authors: Xiao Mingsong , Bao Fangyin , Wang Yuliang , Liu Huabin , He Jixiang
Published: July 2020

Background：Traditional Chinese medicines (TCMs) had been proven to stimulate digestion, promote growth, boost immune response, and reduce inflammatory potential in aquaculture, but its action mechanism was still lack of holistic interpretation. Results: The UPLC-Triple-TOF-MS/MS based platform was developed to investigate the serum metabolic profile associated with the growth performance and immunity in Pelodiscus sinensis fed with the diet added with TCMs feeding additive. The final weight and specific growth rate of TG2 groups was significantly the highest (p ˂ 0.05), and the feed conversion ratio of TG2 groups was significantly the lowest (p ˂ 0.05) compared to the CG group. In the metabolomics assay, a total of 795 (VIP > 1) out of 3089 variable ions were significantly different between the TG2 group and CG group. 43 potential biomarkers between TG2 and CG groups were finally screened out on the basis of VIP > 1 and p < 0.05. Based on the analysis of MetPA, eleven potential biomarkers and six involved metabolic pathways were significantly regulated with treatment of TCMs. Phenylalanine, tyrosine and tryptophan biosynthesis and Arginine and proline metabolism were the two most heavily affected pathways (Impact >0.2), while Tyrosine metabolism, Cysteine and methionine metabolism and Arginine biosynthesis were relatively lightly affected pathways. Conclusions：The dietary supplementation nineteen TCMs as feed additives could influence the growth performance of the healthy juvenile P. sinensis, and the optimal dose of TCMs for juvenile turtles was 2% TCMs. The UPLC-Triple-TOF-MS based metabonomics may be a useful tool for elucidating the efficacy and mechanism of complex TCM prescriptions.
HMGB1/TNFR1/NF-κB Axis in Prostate cancer: Clinical and Biological Correlation
Authors: Jung Ae Ryang , Kim Ga Eun , Kim Mee Young , Ha U-Syn , Hong Sung-Hoo , Lee Ji Youl , Kim Sae Woong , Park Yong Hyun
Published: July 2020

Background

High mobility group box 1 protein (HMGB1) is known to be associated with progression, metastasis, and poor prognosis of several solid tumors, but the role of HMGB1 in prostate cancer (PCa) has remained unclear. Thus, we aimed to evaluate the clinical significance and the biological mechanism of HMGB1 in PCa.
Methods

To explore the clinical significance of HMGB1 in PCa, we performed IHC analyses using paraffin-embedded tissues from patients with low-, intermediate-, and high-risk PCa and from patients with BPH. Biological role and mechanism of HMGB1 in PCa were analyzed using cell viability, cell cycle, Western blot analyses, proteome profiler antibody array, and co-immunoprecipitation assay.
Results

We showed that increases in the expression of HMGB1 correlated with an increased risk of aggressive PCa, and high expression of HMGB1 was associated with poor biochemical recurrence-free survival in a Korean cohort. The inhibition of HMGB1 expression significantly reduced cell proliferation and increased cell cycle arrest in the sub-G0 phase. It also inhibited the invasive capacity of PCa cells in vitro. The above processes were mediated through the binding with TNFR1, leading to tumor progression by activation of the NF-κB signaling pathway.
Conclusions

We identified that HMGB1 is a critical factor in the development and progression of PCa by regulating the HMGB1/TNFR1/NF-κB signaling pathway. HMGB1/TNFR1 could serve as a novel therapeutic target for improving PCa therapy.
Corticosteroid Therapy of Patients in ICU with Coronavirus Disease 2019(COVID-19): A Single-center, Retrospective, Observational study
Authors: Ruan Zhengshang , Wei Ming , Xuan Si , Qian Aihua , Liu Lijun , Xu Bin , Xu Jing , Jiang Jinjun , Ren Rongrong , Zheng Junhua
Published: July 2020

Background

In December 2019, Coronavirus Disease 2019(COVID-19)occurred in Wuhan, China. The disease is a rapidly spreading to the world. Corticosteroid therapy is used among critically ill patients with COVID-19, but value of corticosteroid therapy is uncertain.
Objective

To investigate the association of corticosteroid therapy on intubation rates.
Methods

This was a retrospective, single-center, observational study performed in ICU at Jin Yin-tan hospital, Wu Han, China. 102 patients with COVID-19 admitted to ICU from 2019.12.31 to 2020.03.31 were selected as the research objects. The clinical data were collected to analyze the general characteristics, clinical symptoms, blood test and corticosteroid therapy. The intubation rate between corticosteroid therapy and non-corticosteroid therapy was compared.
Results

Baseline characteristics of patients between corticosteroid therapy and non-corticosteroid therapy were similar.(p > 0.05). We found that there was no significant difference of intubation rate between corticosteroid therapy and non-corticosteroid(P = 0.575), but there was a significant difference in noninvasive ventilation time between the two groups(P = 0.02).
Conclusion

Corticosteroid therapy cannot reduce intubation rate in ICU patients with COVID-19.
Comparative Analysis of Mycobacterium Tuberculosis-Specific Antigens and T-Cell Mitogen-Stimulated Interferon Gamma Production in Hemodialysis Patients and Healthy Individuals
Authors: Park Heechul , Kim Ye Na , Park Sung-Bae , Kim Junseong , Lim Jaewon , Kim Jungho , Park Ji Young , Kim Sunghyun
Published: July 2020

Background: The incidence of Tuberculosis (TB) is higher in patients undergoing chronic hemodialysis than in the general population; further, both the incidence and development of active TB from latent TB infection (LTBI) are considerably higher in patients undergoing hemodialysis than in any other group. The QuantiFERON-TB Gold In-Tube (QFT-GIT) assay is one of the most commonly used interferon gamma (IFN-γ) release assays (IGRAs) currently. We aim to know T-cell function of hemodialysis patients and the possible QFT false negatives.Methods: In order to analyze the MTB-specific antigen-stimulated IFN-γ release in patients on hemodialysis, the QFT-GIT test was used in this study. A total of 84 hemodialysis patients and 52 healthy subjects were enrolled from Kosin University Gospel Hospital and Catholic University of Pusan, Busan, Republic of Korea; their whole blood samples were collected and used for the present study.Results: The positivity results of the IGRAs in hemodialysis patients and normal subjects were 34/84 (40.4%) and 4/52 (7.6%), respectively. The median value of MTB-specific antigen-stimulated IFN-γ in hemodialysis patients with LTBI and non-LTBI status in hemodialysis patients, healthy individuals were 1.85 IU/mL (4.44ng/mL) and 0.028 IU/mL (0.067 ng/mL) and 0.255 IU/mL (0.612 ng/mL) respectively. In addition, Of the 34 LTBI status in hemodialysis patients, 14 (41.2%) had T-cell mitogen-stimulated IFN-γ levels of 10 or less, and 20 (58.8%) had 10 or more T-cell mitogen-stimulated IFN-γ. Moreover, Of the 49 non-LTBI status in hemodialysis patients, 19 (38.8%) and 30 (61.2%) respectively. On the other hand, there was no low level of T-cell mitogen-stimulated IFN-γ in the healthy individuals.Conclusion: This reveals that T-cell function in hemodialysis patients was reduced as compared to the healthy individuals. Therefore, the cut-off value should be adjusted for the active TB high-risk group when using IGRA tests. The clinical manifestations of TB in patients on hemodialysis are quite non-specific, making timely diagnosis difficult, and delaying the initiation of curative treatment, delay being a major determinant of outcome.
Distribuição dos profissionais de contabilidade nas microrregiões brasileiras: uma análise econométrica-espacial
Authors: Aparecida dos Santos Zenatta Francine , Boschetti Adamczyk Willian
Published: July 2020

Objetivo: Identificar os fatores socioeconômicos que influenciam a distribuição espacial dos profissionais de contabilidade nas microrregiões brasileiras.

Metodologia: Utiliza-se os microdados da Relação Anual de Informações Sociais (RAIS) de 2016, dados socioeconômicos do IBGE para produto per capita, densidade demográfica, número de empresas e organizações atuantes e o Índice de Desenvolvimento Humano Municipal de 2016 estimado pela FIRJAN. Os métodos quantitativos empregados para investigar o relacionamento entre as variáveis incluem métodos de análise exploratória espacial, como os testes de correlação espacial I de Moran. Aplica-se técnicas de regressão múltipla e regressão espacial, considerando como variável explicada a proporção de profissionais contábeis por microrregiões brasileiras.

Resultados: Os resultados obtidos apontam o IDHM como a variável mais explicativa para a presença de profissionais de contabilidade, além do número de estabelecimentos atuantes em uma região. Assim, a distribuição de profissionais contábeis é heterogênea em consequência da dependência espacial das variáveis.

Contribuições do Estudo: Incorpora os efeitos de dependência espacial a fim de identificar a contribuição individual de cada fator socioeconômico para a localização dos profissionais de contabilidade.
Comportamento das despesas orçamentárias durante o período eleitoral: uma análise em painel de dados nos municípios brasileiros
Authors: Crispim da Silva Gilberto , Alberton Luiz , Ferreira Celma Duque , Lopes Jorge Expedito de Gusmão
Published: July 2020

Objetivo: A partir da lente de ciclo orçamentário político (COP), investigou-se o comportamento das despesas empenhadas, dos gastos com investimentos e captação de empréstimos em período eleitoral, nos municípios brasileiros com população igual ou superior a 50 mil habitantes, no período de 2000-2016, compreendendo 353 clusters e 6001 observações. Investigou-se também se esses municípios cumprem as exigências legais sobre o uso de recursos orçamentários em ano de eleição. O estudo foi motivado pela falta de consenso na literatura sobre o tema em questão.

Metodologia: Foram construídas quatro hipóteses de pesquisa para auxiliar na consecução dos objetivos propostos. Os dados foram coletados dos sites do IBGE, STE e STN. Os dados foram analisados por meio do método de dados em painel balanceado, agrupados por municípios e região, com aplicação de regressão tobit e testes de robustez de Hausman, Breusch-Pagan Lagrange e F de Chow. Esse método abrangeu intervalos de confiança em 99%, 77%, 79% e 84% de explicação de comportamento entre as variáveis.

Resultado: Os resultados apontam que não houve mudanças das despesas empenhadas antes, durante e após período eleitoral, independente de igualdades partidárias e eleições em dois turnos, diferente do resultado de alguns estudos. Já quanto aos gastos com investimentos e captação de empréstimos em período eleitoral, o estudo sugere aumento médio em 9% e 68% respectivamente, e isso é mais intenso quando há igualdade partidária entre governos municipais e estaduais, principalmente em processo de reeleição. Quanto ao cumprimento das exigências legais sobre uso de recursos orçamentários em ano eleitoral, o estudo indica que os governos locais não cumprem as exigências normativas.

Contribuições do estudo: Contribui para a literatura específica, porque apresenta resultados robustos sobre a falta de consenso existente no tema em questão, com também para futuras pesquisas envolvendo municípios com menor população e comparação entre regiões e países.