bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Evolution of Structural Characteristics of Humic Acid Generated during the Continuous Anaerobic Digestion and Its Potential for Chromium Adsorption and Reduction
Authors: Wang Xiqing , Tian Pengjiao , Muhmood Atif , Liu Juan , Su Yingjie , Zhang Qianqian , Zheng Yi , Dong Renjie
Published: July 2022

Humic acid (HA), as an important by-product, has been demonstrated to affect anaerobic digestion performance and subsequent land application of digestate via the batch anaerobic digestion process. However, the knowledge about the evolution of structure and function of HA during continuous anaerobic digestion (AD) is still unclear. Therefore, the current study examined the structural changes in HA produced during the continuous AD process and its metal-adsorption-reduction abilities. The results of three-dimensional fluorescence spectroscopy showed a general upsurge in humic-like components’ abundance (70–77%), with an increase in humification index (2.56–3.43). Likewise, the content of HA increased from 4.8 g L−1 to 6.9 g L−1 in the continuous AD process. The evolution of C-H, O-H, C=O, C=C, and C-O functional groups of HA was observed via the 2D COS FTIR analysis. Moreover, the concurrent dynamics of functional groups contributed to the higher adsorption (255.2 mg g−1) of Cr (VI) and reduction (60.3 mg g−1) of Cr (VI) to Cr (III) after 168 days of the continuous AD process. The findings of the current study not only advanced understanding of the evolution of HA during continuous anaerobic digestion and its metal remediation potential but also support further research toward developing an eco-friendly and innovative strategy for the remediation of heavy metals contaminated soils employing anaerobic digestate as an auxiliary agent.
Modern Pyromes: Biogeographical Patterns of Fire Characteristics across the Contiguous United States
Authors: Cattau Megan , Mahood Adam , Balch Jennifer , Wessman Carol
Published: July 2022

In recent decades, wildfires in many areas of the United States (U.S.) have become larger and more frequent with increasing anthropogenic pressure, including interactions between climate, land-use change, and human ignitions. We aimed to characterize the spatiotemporal patterns of contemporary fire characteristics across the contiguous United States (CONUS). We derived fire variables based on frequency, fire radiative power (FRP), event size, burned area, and season length from satellite-derived fire products and a government records database on a 50 km grid (1984–2020). We used k-means clustering to create a hierarchical classification scheme of areas with relatively homogeneous fire characteristics, or modern ‘pyromes,’ and report on the model with eight major pyromes. Human ignition pressure provides a key explanation for the East-West patterns of fire characteristics. Human-dominated pyromes (85% mean anthropogenic ignitions), with moderate fire size, area burned, and intensity, covered 59% of CONUS, primarily in the East and East Central. Physically dominated pyromes (47% mean anthropogenic ignitions) characterized by relatively large (average 439 mean annual ha per 50 km pixel) and intense (average 75 mean annual megawatts/pixel) fires occurred in 14% of CONUS, primarily in the West and West Central. The percent of anthropogenic ignitions increased over time in all pyromes (0.5–1.7% annually). Higher fire frequency was related to smaller events and lower FRP, and these relationships were moderated by vegetation, climate, and ignition type. Notably, a spatial mismatch between our derived modern pyromes and both ecoregions and historical fire regimes suggests other major drivers for modern U.S. fire patterns than vegetation-based classification systems. This effort to delineate modern U.S. pyromes based on fire observations provides a national-scale framework of contemporary fire regions and may help elucidate patterns of change in an uncertain future.
Characterization of Purified Mulberry Leaf Glycoprotein and Its Immunoregulatory Effect on Cyclophosphamide-Treated Mice
Authors: Shan Yangwei , Sun Chongzhen , Li Jishan , Shao Xin , Wu Junfeng , Zhang Mengmeng , Yao Hong , Wu Xiyang
Published: July 2022

Mulberry leaf protein is a potentially functional food component and health care agent with antioxidant and anti-inflammatory properties. However, its composition, immunoregulatory effects, and gut microbial regulatory effects are unclear. Herein, ultra-filtrated and gel-fractionated mulberry leaf protein (GUMP) was characterized. Its effects on cyclophosphamide-induced immunosuppressed mice were further investigated. The results indicated that GUMP is a glycoprotein mainly containing glucose, arabinose, and mannose with 9.23% total sugar content. Its secondary structure is mainly β-sheet. LC–MS/MS analysis showed that GUMP closely matched with a 16.7 kDa mannose-binding lectin and a 52.7 kDa Rubisco’s large subunit. GUMP intervention significantly improved serous TNF-α, IL-6, and IL-2 contents; increased serum immunoglobulins (IgA and IgG) levels; and reversed splenic damage prominently. Moreover, GUMP administration increased fecal shot-chain fatty acid concentration and up-regulated the relative abundance of Odoribacter, which was positively correlated with SCFAs and cytokine contents. Overall, GUMP alleviated immunosuppression through the integrated modulation of the gut microbiota and immune response. Therefore, GUMP could be a promising dietary supplement to help maintain gut health.
Second Derivative Block Hybrid Methods for the Numerical Integration of Differential Systems
Authors: Yakubu Dauda Gulibur , Shokri Ali , Kumleng Geoffrey Micah , Marian Daniela
Published: July 2022

The second derivative block hybrid method for the continuous integration of differential systems within the interval of integration was derived. The second derivative block hybrid method maintained the stability properties of the Runge–Kutta methods suitable for solving stiff differential systems. The lack of such stability properties makes the continuous solution not reliable, especially in solving large stiff differential systems. We derive these methods by using one intermediate off-grid point in between the familiar grid points for continuous solution within the interval of integration. The new family had a high accuracy, non-overlapping piecewise continuous solution with very low error constants and converged under the suitable conditions of stability and consistency. The results of computational experiments are presented to demonstrate the efficiency and usefulness of the methods, which also indicate that the block hybrid methods are competitive with some strong stability stiff integrators.
Effect of Heat-Moisture Treatment on the Physicochemical Properties and Starch Digestibility of Mix Powder (Wheat Flour-Black Soybean Flour) and Corresponding Cookies
Authors: Yang Liping , Wang Sunyan , Li Songnan , Zhao Gongqi , Du Chuanlai
Published: July 2022

In order to improve the nutritional value and reduce starch the digestibility of black soybean cookies, superfine black soybean flour was modified by heat-moisture treatment (HMT). The physicochemical properties, structure analysis of the flour samples and corresponding dough, and nutritional, physical, and textural properties of the cookies were investigated. After HMT, the water and lactic acid retention capacity and the oil binding capacity of mix powder dramatically increased, being almost twice the value of the untreated sample. HMT increased gelatinization temperature by about 10 °C but decreased gelatinization enthalpy. HMT had no apparent effect on the morphology and size of granules, but some cracks and pores appeared on the HMT-mix powder granules and corresponding dough. Fourier transform infrared spectroscopy analysis showed that the ordered structure of dough was unaffected during HMT. After HMT, the thickness, density, and baking loss of the cookies increased, and the spread ratio decreased. HMT dramatically increased the chemical score of cookies from 12.35% in mix powder cookies to 19.64% in HMT-mix powder cookies. HMT decreased the rapidly digestible starch content, while the slowly digestible starch increased from 45.97% in mix powder cookies to 49.31% in HMT-mix powder cookies, and RS increased from 21.64% to 26.87%. Overall, HMT did not have a negative effect on the processing properties and microstructure and secondary structure of the dough, or the physical properties and quality of the cookies, but significantly improved the nutritional properties and decreased the starch digestibility of the cookies.
SLC25A12 Missense Variant in Nova Scotia Duck Tolling Retrievers Affected by Cerebellar Degeneration—Myositis Complex (CDMC)
Authors: Christen Matthias , Rupp Stefan , Van Soens Iris , Bhatti Sofie F. M. , Matiasek Kaspar , von Klopmann Thilo , Jagannathan Vidhya , Madden Indiana , Batcher Kevin , Bannasch Danika , Leeb Tosso
Published: July 2022

We investigated two litters of distantly related Nova Scotia Duck Tolling Retrievers (NSDTR), of which four puppies were affected by cerebellar signs with or without neuromuscular weakness. The phenotype was termed cerebellar degeneration—myositis complex (CDMC). We suspected a heritable condition and initiated a genetic analysis. The genome of one affected dog was sequenced and compared to 565 control genomes. This search yielded a private protein-changing SLC25A12 variant in the affected dog, XM_038584842.1:c.1337C>T, predicted to result in the amino acid change XP_038440770.1:(p.Pro446Leu). The genotypes at the variant co-segregated with the phenotype as expected for a monogenic autosomal recessive mode of inheritance in both litters. Genotyping of 533 additional NSDTR revealed variant allele frequencies of 3.6% and 1.3% in a European and a North American cohort, respectively. The available clinical and biochemical data, together with current knowledge about SLC25A12 variants and their functional impact in humans, mice, and dogs, suggest the p.Pro446Leu variant is a candidate causative defect for the observed phenotype in the affected dogs.
Identification of Antitumor miR-30e-5p Controlled Genes; Diagnostic and Prognostic Biomarkers for Head and Neck Squamous Cell Carcinoma
Authors: Minemura Chikashi , Asai Shunichi , Koma Ayaka , Kikkawa Naoko , Kato Mayuko , Kasamatsu Atsushi , Uzawa Katsuhiro , Hanazawa Toyoyuki , Seki Naohiko
Published: July 2022

Analysis of microRNA (miRNA) expression signatures in head and neck squamous cell carcinoma (HNSCC) has revealed that the miR-30 family is frequently downregulated in cancer tissues. The Cancer Genome Atlas (TCGA) database confirms that all members of the miR-30 family (except miR-30c-5p) are downregulated in HNSCC tissues. Moreover, low expression of miR-30e-5p and miR-30c-1-3p significantly predicts shorter survival of HNSCC patients (p = 0.0081 and p = 0.0224, respectively). In this study, we focused on miR-30e-5p to investigate its tumor-suppressive roles and its control of oncogenic genes in HNSCC cells. Transient expression of miR-30e-5p significantly attenuated cancer cell migration and invasive abilities in HNSCC cells. Nine genes (DDIT4, FOXD1, FXR1, FZD2, HMGB3, MINPP1, PAWR, PFN2, and RTN4R) were identified as putative targets of miR-30e-5p control. Their expression levels significantly predicted shorter survival of HNSCC patients (p < 0.05). Among those targets, FOXD1 expression appeared to be an independent factor predicting patient survival according to multivariate Cox regression analysis (p = 0.049). Knockdown assays using siRNAs corresponding to FOXD1 showed that malignant phenotypes (e.g., cell proliferation, migration, and invasive abilities) of HNSCC cells were significantly suppressed. Overexpression of FOXD1 was confirmed by immunostaining of HNSCC clinical specimens. Our miRNA-based approach is an effective strategy for the identification of prognostic markers and therapeutic target molecules in HNSCC. Moreover, these findings led to insights into the molecular pathogenesis of HNSCC.
Design of Smart and Secured Healthcare Service Using Deep Learning with Modified SHA-256 Algorithm
Authors: Mohanty Mohan Debarchan , Das Abhishek , Mohanty Mihir Narayan , Altameem Ayman , Nayak Soumya Ranjan , Saudagar Abdul Khader Jilani , Poonia Ramesh Chandra
Published: July 2022

Background: The modern era of human society has seen the rise of a different variety of diseases. The mortality rate, therefore, increases without adequate care which consequently causes wealth loss. It has become a priority of humans to take care of health and wealth in a genuine way. Methods: In this article, the authors endeavored to design a hospital management system with secured data processing. The proposed approach consists of three different phases. In the first phase, a smart healthcare system is proposed for providing an effective health service, especially to patients with a brain tumor. An application is developed that is compatible with Android and Microsoft-based operating systems. Through this application, a patient can enter the system either in person or from a remote place. As a result, the patient data are secured with the hospital and the patient only. It consists of patient registration, diagnosis, pathology, admission, and an insurance service module. Secondly, deep-learning-based tumor detection from brain MRI and EEG signals is proposed. Lastly, a modified SHA-256 encryption algorithm is proposed for secured medical insurance data processing which will help detect the fraud happening in healthcare insurance services. Standard SHA-256 is an algorithm which is secured for short data. In this case, the security issue is enhanced with a long data encryption scheme. The algorithm is modified for the generation of a long key and its combination. This can be applicable for insurance data, and medical data for secured financial and disease-related data. Results: The deep-learning models provide highly accurate results that help in deciding whether the patient will be admitted or not. The details of the patient entered at the designed portal are encrypted in the form of a 256-bit hash value for secured data management.
Characterization of Volatile Compounds from Tea Plants (Camellia sinensis (L.) Kuntze) and the Effect of Identified Compounds on Empoasca flavescens Behavior
Authors: Fauziah Fani , Permana Agus Dana , Faizal Ahmad
Published: July 2022

The tea green leafhopper, Empoasca flavescens, is a major pest of tea Camellia sinensis (L.) Kuntze. Until recently, it has mainly been controlled by pesticides, but their use has led to high levels of toxic residues in plants, which threaten both the environment and human health. Therefore, a safer biological control approach is needed. Tea plants produce many volatile compounds, and different tea clones differ in their resistance to the pest. We explored the possibility that volatile compounds influence the resistance of tea. Here, we assessed the resistance of 15 clones of tea plants to the pest, the volatile compounds produced by the clones, and the effects of the compounds on E. flavescens behavior. Six clones were classified as resistant, eight as moderately susceptible, and one as susceptible. Fresh leaf samples from resistant and susceptible clones were analyzed using HS–SPME–GC–MS. Sesquiterpenes and monoterpenes were two major groups characterized, representing 30.15% and 26.98% of the total compounds, respectively. From our analysis, we conclude that 3-hexen-1-ol, 2,6-dimethyleneoct-7-en-3-one, humulene, β-bourbonene, styrene, and benzaldehyde were important for the resistance and susceptibility of the clones. In a bioassay, E. flavescens were attracted to β-ocimene and methyl salicylate, but avoided linalool compounds.
Underestimation of Radiation Doses by Compliance of Wearing Dosimeters among Fluoroscopically-Guided Interventional Medical Workers in Korea
Authors: Lee Won Jin , Jang Eun Jin , Kim Kyeong Seo , Bang Ye Jin
Published: July 2022

This study aimed to estimate the level of underestimation of National Dose Registry (NDR) doses based on the workers’ dosimeter wearing compliance. In 2021, a nationwide survey of Korean medical radiation workers was conducted. A total of 989 medical workers who performed fluoroscopically-guided interventional procedures participated, and their NDR was compared with the adjusted doses by multiplying the correction factors based on the individual level of dosimeter compliance from the questionnaire. Ordinal logistic regression analysis was performed to identify the factors for low dosimeter wearing. Based on the data from the NDR, the average annual effective radiation dose was 0.95 mSv, while the compliance-adjusted dose was 1.79 mSv, yielding an 89% increase. The risks for low compliance with wearing a badge were significantly higher among doctors, professionals other than radiologists or cardiologists, workers not frequently involved in performing fluoroscopically-guided interventional procedures, and workers who did not frequently wear protective devices. This study provided quantitative information demonstrating that the NDR data may have underestimated the actual occupational radiation exposure. The underestimation of NDR doses may lead to biased risk estimates in epidemiological studies for radiation workers, and considerable attention on dosimetry wearing compliance is required to interpret and utilize NDR data.
A Scoping Review of Psychological Sense of Community among Community-Dwelling Older Adults
Authors: Buckley Thomas D.
Published: July 2022

Psychological sense of community (PSOC) is an important construct for health and well-being outcomes for community-dwelling older adults. Drawing on the Ecological Theory of Aging and the Age-Friendly Cities (AFC) framework, this scoping review explored how PSOC has been used in research with community-dwelling older adults. This study examined antecedents, correlates, and outcomes of PSOC, with a focus on relevance to theory and practice. Databases were searched between 1986 and 2021 for peer-reviewed journal articles. Searches identified 582 unique articles, and 28 were included in the final sample. Three primary themes emerged in the synthesis: relevance to the AFC framework, PSOC as a predictor of health and well-being outcomes, and the role of PSOC in relocation. Findings from this review show that PSOC serves as a mechanism that links the social and physical AFC environments with health and well-being outcomes. This review also presents mechanisms for how features of the environment relate to PSOC. These findings demonstrate the role of PSOC as a resource to improve person–environment fit. Results from this review can be used to guide future research and inform theory, policy, and practice.
What Type of Housework Happiness Do You Prefer? Does Gender and Health Matter? A Taiwanese Study
Authors: Lee Ching-Fen , Tang Shain-May
Published: July 2022

The purposes of this study was to discover the circumstances in which people gain happiness from performing housework and to understand gender differences in housework-related happiness. We used national data from the Taiwan Social Change Survey conducted in 2011. Only married and cohabiting respondents were included in this study (N = 1250). Two types of housework happiness were developed: the goal satisfaction type (GST) and the activity enjoyment type (AET), based on interview results in pilot studies and the concept of positive psychology. We found that the significant variables on the two types of housework-related happiness for the total sample were gender, socioeconomic status, gender role attitude, decision-making power, relative feminine housework, and respondent’s health. In addition, the effects on the two types of housework-related happiness for males and females are different. Most people derive happiness from housework if their preferences for type of housework and their personal characteristics are matched. It is possible to transform an otherwise monotonous daily activity into a source of happiness through the process of understanding your housework preference type, learning to enjoy the beauty of housework, and creating fun with chores for families. However, the survey (TSCS) used in this study was carried out over 10 years ago (2011) and the results may be somewhat different in Taiwan today.
Chronotropic Response and Heart Rate Variability before and after a 160 m Walking Test in Young, Middle-Aged, Frail, and Non-Frail Older Adults
Authors: Álvarez-Millán Lesli , Lerma Claudia , Castillo-Castillo Daniel , Quispe-Siccha Rosa M. , Pérez-Pacheco Argelia , Rivera-Sánchez Jesús , Fossion Ruben
Published: July 2022

The frailty syndrome is characterized by a decreased capacity to adequately respond to stressors. One of the most impaired physiological systems is the autonomous nervous system, which can be assessed through heart rate (HR) variability (HRV) analysis. In this article, we studied the chronotropic response (HR and HRV) to a walking test. We also analyzed HRV indices in rest as potential biomarkers of frailty. For this, a 160 m-walking test and two standing rest tests (before and after the walking) were performed by young (19–29 years old, n = 21, 57% women), middle-aged (30–59 years old, n = 16, 62% women), and frail older adults (>60 years old, n = 28, 40% women) and non-frail older adults (>60 years old, n = 15, 71% women), classified with the FRAIL scale and the Clinical Frailty Scale (CFS). Frequency domain parameters better allowed to distinguish between frail and non-frail older adults (low-frequency power LF, high-frequency power HF (nu), LF/HF ratio, and ECG-derived respiration rate EDR). Frail older adults showed an increased HF (nu) and EDR and a reduced LF (nu) and LF/HF compared to non-frail older adults. The increase in HF (nu) could be due to a higher breathing effort. Our results showed that a walk of 160 m is a sufficient cardiovascular stressor to exhibit an attenuated autonomic response in frail older adults. Several HRV indices showed to be potential biomarkers of frailty, being LF (nu) and the time required to reach the maximum HR the best candidates.
Competency Gradients in Advanced Practice Nurses, Specialist Nurses, and Registered Nurses: A Multicentre Cross-Sectional Study
Authors: Gutiérrez-Rodríguez Laura , García-Mayor Silvia , León-Campos Álvaro , Gómez-González Alberto José , Pérez-Ardanaz Bibiana , Rodríguez-Gómez Susana , Fajardo-Samper Marta , Morilla-Herrera Juan Carlos , Morales-Asencio José Miguel
Published: July 2022

(1) Background: Identifying differences in the competencies of different areas of nursing is a crucial aspect for determining the scope of practice. This would facilitate the creation of a formal structure for clinical practice in advanced and specialised services. The aims of this study are to analyse the distribution of advanced competencies in registered, specialist and advanced practice nurses in Spain, and to determine the level of complexity of the patients attended by these nurses. (2) Methods: A cross-sectional study was developed on registered, specialist and advanced practice nurses, all of whom completed an online survey on their perceived level of advanced competencies and their professional characteristics. (3) Results: In total, 1270 nurses completed the survey. Advanced practice nurses recorded the highest self-perceived level of competency, especially for the dimensions of evidence-based practice, autonomy, leadership and care management. (4) Conclusions: Among registered, specialist and advanced practice nurses, there are significant differences in the level of self-perceived competencies. Patients attended by advanced practice nurses presented the highest levels of complexity. Understanding these differences could facilitate the creation of a regulatory framework for clinical practice in advanced and specialized services.
From Self-Doubt to Pride: Understanding the Empowering Effects of Delivering School-Based Wellness Programmes for Emerging Adult Facilitators—A Qualitative Study
Authors: Ankori Galia , Tzabari Dana , Hager Tamar , Golan Moria
Published: July 2022

Ample literature exists on the impact of prevention programmes on their target audience, while much less is known about how delivering such programmes influences their facilitators. Even less literature exists on the emotional and social processes that form this potential impact on facilitators. The current study analysed qualitative in-depth, non-structured interviews, as well as written essays provided by 33 student-facilitators who delivered the “Favoring Myself” programme in Israel during 2019–2021. This school-based wellness programme comprised 10 weekly, 90 min sessions on self-care behaviours, media literacy, self-esteem, and positive body image, which are well-known protective factors against risky behaviours. A thematic analysis was applied to explore the main themes in the collected data. An interesting affective transformation from self-doubt to pride in themselves emerged as a shared experience of these young facilitators. Facilitators related their ability to facilitate the programme, as well as to undergo an individual maturation and empowerment experience, to certain components of the programme itself, such as the preparatory course, individual supervision, and the peer-group experience. This shift from doubt to pride is discussed using two frameworks—a theoretical discourse of emerging adulthood as a developmental stage, and the self-determination theory.
Arch-Support Insoles Benefit the Archery Performance and Stability of Compound Archers
Authors: Wu Ting-Ting , Lo Shin-Liang , Chen Hui , Yang Jeng-Sheng , Peng Hsien-Te
Published: July 2022

The purpose of this study was to analyze the effects of the use of arch-support insoles on the archery performance and center of plantar pressure (CoP) excursion in compound archers. Fifteen highly skilled compound archers were the subjects. A pressure plate was used to measure the CoP excursion and percentage distribution of plantar pressure. The parameters were compared between archers wearing flat and arch-support insoles using a paired-sample t-test. The results demonstrated that the shooting score in archers wearing the arch-support insole was significantly greater than in those wearing the flat insoles. The CoP excursion of the left foot, right foot, and both feet in archers wearing the arch-support insole were significantly smaller than in those wearing the flat insole. The distributed percentage of the plantar pressure showed that the arch-support insole significantly reduced the plantar pressure in the left posterior zone by 3.54% compared with the flat insole, and increased the plantar pressure in the right anterior zone by 2.54%. The principal conclusion was that compound archers wearing arch-support insoles during the arrow-release process can reduce the CoP excursion of the foot and increase their shooting score. The plantar pressure was distributed evenly in arch-support insoles.
Effect of Attachment and Child Health (ATTACHTM) Parenting Program on Parent-Infant Attachment, Parental Reflective Function, and Parental Depression
Authors: Anis Lubna , Ross Kharah , Ntanda Henry , Hart Martha , Letourneau Nicole
Published: July 2022

High-risk families exposed to toxic stressors such as family violence, depression, addiction, and poverty, have shown greater difficulty in parenting young children. In this study, we examined the effectiveness of ATTACHTM, a 10–12 session manualized one-on-one parental Reflective Function (RF)-based parenting program designed for high-risk families. Outcomes of parent-child attachment and parental RF were assessed via the Strange Situation Procedure (SSP) and Reflective Function Scale (RFS), respectively. The protective role of ATTACHTM on parental depression was also assessed. Data were available from caregivers and their children < 6 years of age who participated in five pilot randomized control trials (RCTs) and quasi-experimental studies (QES; n = 40). Compared with the control group, caregivers who received the ATTACHTM-program demonstrated a greater likelihood of secure attachment with their children (p = 0.004) and higher parental RF [self (p = 0.004), child (p = 0.001), overall (p = 0.002)] in RCTs. A significant improvement in parental RF (p = 0.000) was also observed in the QES within ATTACHTM group analysis. As attachment security increased, receiving the ATTACHTM program may be protective for depressed caregivers. Results demonstrated the promise of ATTACHTM for high-risk parents and their young children.
Ciprofloxacin and Trimethoprim Adsorption/Desorption in Agricultural Soils
Authors: Rodríguez-López Lucía , Santás-Miguel Vanesa , Cela-Dablanca Raquel , Núñez-Delgado Avelino , Álvarez-Rodríguez Esperanza , Pérez-Rodríguez Paula , Arias-Estévez Manuel
Published: July 2022

The current research focuses on the adsorption/desorption characteristics of the antibiotics ciprofloxacin (CIP) and trimethoprim (TRI) taking place in 17 agricultural soils, which are studied by means of batch-type experiments. The results show that adsorption was higher for CIP, with Freundlich KF values ranging between 1150 and 5086 Ln µmol1−n kg−1, while they were between 29 and 110 Ln µmol1−n kg−1 in the case of TRI. Other parameters, such as the Langmuir maximum adsorption capacity (qm(ads)), as well as the Kd parameter in the linear model and also the adsorption percentages, follow the same trend as KF. Desorption was lower for CIP (with KF(des) values in the range 1089–6234 Ln µmol1−n kg−1) than for TRI (with KF(des) ranging between 26 and 138 Ln µmol1−n kg−1). The higher irreversibility of CIP adsorption was also confirmed by its lower nF(des)/nF(ads) ratios, compared to TRI. Regarding soil characteristics, it was evidenced that nitrogen and carbon contents, as well as mineral fractions, had the highest influence on the adsorption/desorption process. These results can be considered relevant as regards the fate of both antibiotics when they reach the environment as pollutants and therefore could be considered in assessment procedures focused on environmental and public health aspects.
Building Process-Oriented Data Science Solutions for Real-World Healthcare
Authors: Fernandez-Llatas Carlos , Martin Niels , Johnson Owen , Sepulveda Marcos , Helm Emmanuel , Munoz-Gama Jorge
Published: July 2022

The COVID-19 pandemic has highlighted some of the opportunities, problems and barriers facing the application of Artificial Intelligence to the medical domain. It is becoming increasingly important to determine how Artificial Intelligence will help healthcare providers understand and improve the daily practice of medicine. As a part of the Artificial Intelligence research field, the Process-Oriented Data Science community has been active in the analysis of this situation and in identifying current challenges and available solutions. We have identified a need to integrate the best efforts made by the community to ensure that promised improvements to care processes can be achieved in real healthcare. In this paper, we argue that it is necessary to provide appropriate tools to support medical experts and that frequent, interactive communication between medical experts and data miners is needed to co-create solutions. Process-Oriented Data Science, and specifically concrete techniques such as Process Mining, can offer an easy to manage set of tools for developing understandable and explainable Artificial Intelligence solutions. Process Mining offers tools, methods and a data driven approach that can involve medical experts in the process of co-discovering real-world evidence in an interactive way. It is time for Process-Oriented Data scientists to collaborate more closely with healthcare professionals to provide and build useful, understandable solutions that answer practical questions in daily practice. With a shared vision, we should be better prepared to meet the complex challenges that will shape the future of healthcare.
Raising Awareness on the Clinical and Forensic Aspects of Jellyfish Stings: A Worldwide Increasing Threat
Authors: Cunha Sara Almeida , Dinis-Oliveira Ricardo Jorge
Published: July 2022

Jellyfish are ubiquitous animals registering a high and increasing number of contacts with humans in coastal areas. These encounters result in a multitude of symptoms, ranging from mild erythema to death. This work aims to review the state-of-the-art regarding pathophysiology, diagnosis, treatment, and relevant clinical and forensic aspects of jellyfish stings. There are three major classes of jellyfish, causing various clinical scenarios. Most envenomations result in an erythematous lesion with morphological characteristics that may help identify the class of jellyfish responsible. In rare cases, the sting may result in delayed, persistent, or systemic symptoms. Lethal encounters have been described, but most of those cases happened in the Indo-Pacific region, where cubozoans, the deadliest jellyfish class, can be found. The diagnosis is mostly clinical but can be aided by dermoscopy, skin scrapings/sticky tape, confocal reflectance microscopy, immunological essays, among others. Treatment is currently based on preventing further envenomation, inactivating the venom, and alleviating local and systemic symptoms. However, the strategy used to achieve these effects remains under debate. Only one antivenom is currently used and covers merely one species (Chironex fleckeri). Other antivenoms have been produced experimentally but were not tested on human envenomation settings. The increased number of cases, especially due to climate changes, justifies further research in the study of clinical aspects of jellyfish envenoming.
Sports and Health, Second Edition
Authors: Nikolaidis Pantelis T. , Knechtle Beat
Published: July 2022

The International Journal of Environmental Research and Public Health (IJERPH) has increased its publications of scientific papers related to exercise; a search of Pubmed (on 22 June 2022) using IJERPH and exercise as keywords showed 1788 entries for 2021 compared to 80 entries in 2016 [...]
The Association between Working Hours Flexibility and Well-Being Prior to and during COVID-19 in South Korea
Authors: Nerobkova Nataliya , Park Yu Shin , Park Eun-Cheol , Jang Suk-Yong
Published: July 2022

Objective: This study examined the relationship between the flexibility of work schedule arrangements and well-being among full-time workers prior to and after the coronavirus disease (COVID-19) outbreak in South Korea. Methods: Data from the fifth 2017 and sixth 2020–2021 Korean Working Conditions Survey, including a final sample of 45,137 participants (22,460 males; 22,677 females), were used. Multiple logistic regression was performed to establish the association between schedule arrangement types and the 5-item World Health Organization Well-Being Index. Results: The study found an association between flexible schedule arrangements and good well-being in 2017: “little flexibility” (odds ratio (OR), 1.33; 95% confidence interval (CI), 1.27–1.48), “moderate flexibility” (OR, 1.48; 95% CI, 1.28–1.71), and “high flexibility” (OR, 1.35; 95% CI, 1.06–1.72). During COVID-19, only workers with “high flexibility” were likely to have good well-being (OR, 1.49; 95% CI, 1.18–1.88), while the association between well-being and “low flexibility” (OR, 1.06; 95% CI, 0.96–1.17) and “moderate flexibility” types (OR, 0.66; 95% CI 0.59–0.75) decreased. This study found that flexible working hours may contribute to better well-being among full-time workers. However, the impact of the COVID-19 pandemic on working conditions and employee well-being should be addressed while setting working hours.
Restored Life of Elite Athletes after Spinal Cord Injury
Authors: Zurek Grzegorz , Goraczko Agata , Żurek Alina , Lachowicz Maciej , Kujawa Katarzyna
Published: July 2022

Spinal cord injury (SCI) affects every aspect of human life: medical, psychological, social, material. People with SCI face a variety of secondary conditions (e.g., chronic pain, urinary tract infections, cognitive impairment) that place a significant emotional burden, resulting in an increased risk of depression and reduced quality of life. The purpose of this study was to better understand the coping strategies and to identify factors that promote or hinder the successful adjustment of elite athletes after SCI. Individual semi-structured interviews were conducted with eight top athletes after spinal cord injury. The interviews were recorded, transcribed, and then thematically analyzed using MAXQDA software. Thematic analysis identified the following categories: coping, athletic identity, and adjustment. The results of the study indicate that loss of functional ability does not cause loss of athlete identity. Elite athletes live a life consistent with this identity, attempting to maintain it despite the loss of physical fitness. Involvement in sports provides meaning and is a positive factor in the process of disability acceptance, which is essential in the process of adjustment to injury and also provides group belonging.
An Accurate and Efficient Quaternion-Based Visualization Approach to 2D/3D Vector Data for the Mobile Augmented Reality Map
Authors: Wang Chenliang , Huang Kejia , Shi Wenjiao
Published: July 2022

Increasingly complex vector map applications and growing multi-source spatial data pose a serious challenge to the accuracy and efficiency of vector map visualization. It is true especially for real-time and dynamic scene visualization in mobile augmented reality, with the dramatic development of spatial data sensing and the emergence of AR-GIS. Such issues can be decomposed into three issues: accurate pose representation, fast and precise topological relationships computation and high-performance acceleration methods. To solve these issues, a novel quaternion-based real-time vector map visualization approach is proposed in this paper. It focuses on precise position and orientation representation, accurate and efficient spatial relationships calculation and acceleration parallel rendering in mobile AR. First, a quaternion-based pose processing method for multi-source spatial data is developed. Then, the complex processing of spatial relationships is mapped into simple and efficient quaternion-based operations. With these mapping methods, spatial relationship operations with large computational volumes can be converted into efficient quaternion calculations, and then the results are returned to respond to the interaction. Finally, an asynchronous rendering acceleration mechanism is also presented in this paper. Experiments demonstrated that the method proposed in this paper can significantly improve vector visualization of the AR map. The new approach, when compared to conventional visualization methods, provides more stable and accurate rendering results, especially when the AR map has strenuous movements and high frequency variations. The smoothness of the user interaction experience is also significantly improved.
Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation
Authors: Pillo Gelsomina , Mascolo Maria Grazia , Zanzi Cristina , Rotondo Francesca , Serra Stefania , Bortone Francesco , Grilli Sandro , Vaccari Monica , Jacobs Miriam N. , Colacci Annamaria
Published: July 2022

The Transformics Assay is an in vitro test which combines the BALB/c 3T3 Cell Transformation Assay (CTA) with microarray transcriptomics. It has been shown to improve upon the mechanistic understanding of the CTA, helping to identify mechanisms of action leading to chemical-induced transformation thanks to RNA extractions in specific time points along the process of in vitro transformation. In this study, the lowest transforming concentration of the carcinogenic benzo(a)pyrene (B(a)P) has been tested in order to find molecular signatures of initial events relevant for oncotransformation. Application of Enrichment Analysis (Metacore) to the analyses of the results facilitated key biological interpretations. After 72 h of exposure, as a consequence of the molecular initiating event of aryl hydrocarbon receptor (AhR) activation, there is a cascade of cellular events and microenvironment modification, and the immune and inflammatory responses are the main processes involved in cell response. Furthermore, pathways and processes related to cell cycle regulation, cytoskeletal adhesion and remodeling processes, cell differentiation and transformation were observed.
Gold(III) Complexation in the Presence of the Macropolyhedral Hydridoborate Cluster [B20H18]2−
Authors: Avdeeva Varvara V. , Vologzhanina Anna V. , Kubasov Alexey S. , Akhmadullina Nailya S. , Shishilov Oleg N. , Malinina Elena A. , Kuznetsov Nikolay T.
Published: July 2022

Gold(III) complexation with the octadecahydrido-eicosaborate anion [B20H18]2− was studied for the first time. It was found that when gold(III) complexes [Au(L)Cl2]BF4 (L = bipy, phen) reacted with [B20H18]2−, complexes [Au(L)Cl2]2[B20H18] were isolated. The compounds consisted of a cationic gold(III) complex [Au(L)Cl2]+ and the hydridoborate cluster as a counterion. X-ray diffraction studies revealed weak B–H...Au interactions for both compounds. Note that more reactive anions [BnHn]2− (n = 10, 12) in similar reactions with gold(III) complexes resulted in gold mirror reactions.
Low Prevalence of Cardiomyopathy in Patients with Mitochondrial Disease and Neurological Manifestations
Authors: Nikhanj Anish , Bautista Jesi , Siddiqi Zaeem A. , Phan Cecile L. , Oudit Gavin Y.
Published: July 2022

Patients with mitochondrial diseases can develop cardiomyopathy but with variable expressivity and penetrance. Our prospective study enrolled and evaluated a cohort of 53 patients diagnosed with chronic progressive ophthalmoplegia (CPEO, n = 34), Kearns–Sayre syndrome (KSS, n = 3), neuropathy ataxia and retinitis pigmentosa (NARP, n = 1), myoclonic epilepsy with ragged red fibers (MERRF, n = 1), Harel–Yoon Syndrome (HYS, n = 1) and 13 patients with undefined mitochondrial diseases, presenting primarily with neurological symptoms. Over a 4-year period, six patients in our study cohort were diagnosed with heart disease (11.3%), with only three patients having defined cardiomyopathy (5.7%). Cardiomyopathy was present in a 21-year-old patient with HYS and two CPEO patients having mild cardiomyopathy at an older age. Two CPEO patients had congenital heart disease, and a third CPEO had LV hypertrophy secondary to hypertension. In three patients, traditional risk factors for heart disease, including dyslipidemia, hypertension, and respiratory disease, were present. The majority of our adult cohort of patients have normal cardiac investigations with a median left ventricular (LV) ejection fraction of 59.0%, indexed LV mass of 67.0 g/m2, and normal diastolic and valvular function at baseline. A 12-lead electrocardiogram showed normal cardiac conduction across the study cohort. Importantly, follow-up assessments showed consistent cardiac structure and function. Our study shows a low prevalence of cardiomyopathy and highlights the breadth of phenotypic variability in patients with mitochondrial disorders. The presence of cardiovascular risk factors and aging are important comorbidities in our cohort.
Effect of Neuroendocrine Neoplasm Treatment on Human Reproductive Health and Sexual Function
Authors: Zamponi Virginia , La Salvia Anna , Tarsitano Maria Grazia , Mikovic Nevena , Rinzivillo Maria , Panzuto Francesco , Giannetta Elisa , Faggiano Antongiulio , Mazzilli Rossella
Published: July 2022

Neuroendocrine neoplasms (NEN) are characterized by a wide clinical heterogeneity and biological variability, with slow progression and long survival in most cases. Although these tumors can affect young adults, there are few studies that focus on the sexual and reproductive system. The aim of this review was to evaluate the effect of NEN treatment, including somatostatin analogues (SSA), targeted therapy (Everolimus and Sunitinib), radiolabeled-SSA and chemotherapy, on male and female reproductive systems and sexual function. This narrative review was performed for all available prospective and retrospective studies, case reports and review articles published up to March 2022 in PubMed. To date, few data are available on the impact of SSA on human fertility and most of studies come from acromegalic patients. However, SSAs seem to cross the blood–placental barrier; therefore, pregnancy planning is strongly recommended. Furthermore, the effect of targeted therapy on reproductive function is still undefined. Conversely, chemotherapy has a well-known negative impact on male and female fertility. The effect of temozolomide on reproductive function is still undefined, even if changes in semen parameters after the treatment have been described. Finally, very few data are available on the sexual function of NEN treatment.
Indicators of the Right Ventricle Systolic and Diastolic Function 18 Months after Coronary Bypass Surgery
Authors: Sumin Alexey N. , Shcheglova Anna V. , Korok Ekaterina V. , Sergeeva Tatjana Ju.
Published: July 2022

Objective. Right ventricular (RV) dysfunction after coronary artery bypass grafting (CABG) is associated with increased mortality and morbidity. In previous studies, the parameters of RV systolic function were mainly assessed, while the dynamics of RV diastolic function after surgery was practically not studied. The aim of this study was to study the dynamics of indicators of systolic and diastolic RV function after CABG as well as to identify factors associated with their presence. Methods. The study included 160 patients who underwent CABG and 36 volunteers with no history of coronary artery disease (CAD) as a control group. Echocardiographic examination of patients was performed to assess systolic and diastolic RV dysfunction before surgery and 18 months after CABG. A level of s’t < 10 cm/sec or TAPSE < 16 mm was considered as a sign of existing RV systolic dysfunction. RV diastolic dysfunction was defined as an Et/At ratio < 0.8 or >2.1 and/or an Et/et’ ratio > 6. Results. In CAD patients 18 months after CABG, there was an increase in the frequency of the right ventricular systolic (from 7.5% to 30%, p < 0.001) and diastolic (from 41.8% to 57.5%, p < 0.001) dysfunction. An increase in TAPSE (p = 0.007), a decrease in e’t (p = 0.005), and the presence of RV systolic dysfunction before surgery (p = 0.023) was associated with a significant increase in the likelihood of detecting RV systolic dysfunction 18 months after CABG (χ2(3) = 17.4, p = 0.001). High values of At before surgery (p = 0.021) and old myocardial infarction (p = 0.023) were significantly associated with an increased likelihood of detection of RV diastolic dysfunction 18 months after CABG (χ2(2) = 10.78, p = 0.005). Conclusions. This study demonstrated that in CAD patients 18 months after CABG, there was an increase in the frequency of right ventricular systolic and diastolic dysfunction. We also established the initial clinical, echocardiographic parameters, and perioperative complications associated with the presence of these changes in the postoperative period. The clinical and prognostic significance of the presence of systolic and/or diastolic RV dysfunction in patients 18 months after CABG remains to be explored.