bluuebunny/crossref_metadata_2025 huggingface dataset:
siRNA Treatments for Diabetic Neuropathy: Obstacles and Delivery
Techniques
Authors: Akhtar Mohammad Shabib , Mohsin Nehal , Zahak Ahmad , Ahmed Khalid Altigani Awad Alkarem , Alhazmi Yasir , Taleuzzaman Mohamad
Published: June 2024

Targeting genes using siRNA shows promise as an approach to alleviate
symptoms of diabetic neuropathy. It focuses on neuropathies and distal symmetric
polyneuropathy (DSPN) to explore the potential use of small interfering RNA (siRNA)
as a treatment for diabetic neuropathy. Timely identification and management of
neuropathy play a critical role in mitigating potential complications. RNAi success
depends on understanding factors affecting small interfering RNA (siRNA) functionality
and specificity. These include sequence space restrictions, structural and sequence
features, mechanisms for nonspecific gene modulation, and chemical modifications.
Addressing these factors enhances siRNA performance for efficient gene silencing and
confidence in RNAi-mediated genomic studies. Diabetic retinopathy, particularly in
South Asian, African, Latin American, and indigenous populations, is a significant
concern due to its association with diabetes. Ethnicity plays a crucial role in its
development and progression. Despite declining rates in the US, global trends remain
concerning, and further research is needed to understand regional differences and
reinforce ethnicity-based screening and treatment protocols. In this regard, siRNA
emerges as a valuable instrument for early intervention strategies. While presenting
promising therapeutic applications, siRNA utilization encounters challenges within
insect pest control contexts, thereby providing insights into enhancing its delivery
mechanisms for neuropathy treatment purposes. Recent advancements in delivery
modalities, such as nanoparticles, allow for the controlled release of siRNA. More
investigation is necessary to grasp the safety and efficacy of siRNA technology fully. It
holds promise in transforming the treatment of diabetic neuropathy by honing in on
particular genes and tackling issues such as inflammation and oxidative stress.
Continuous advancements in delivery techniques have the potential to enhance patient
results significantly. SiRNA targets genes in diabetic neuropathy, curbing nerve
damage and pain and potentially preventing or delaying the condition. Customized
treatments based on genetic variations hold promise for symptom management and
enhancing quality of life.
The Hepatoprotective Effect of a Newly Synthesized 5-mercapto-1,2,4-triazole Derivative based on Nalidixic Acid against CCl4 induced Oxidative Stress in Mice
Authors: Mhaidat Ibrahim , Tahat Lena , Alomari Ghada , AL-Quraan Laiali , Gharaibeh Abeer , Al-Trad Bahaa
Published: June 2024

Background:

Oxidative stress plays a key role in the development of a wide range of
diseases, including diabetes and cancer. Recent studies reported that the derivatives of triazole compounds have a potent antioxidant activity. Therefore, this study was designed to investigate the
hepatoprotective effect of a novel newly synthesized 5-mercapto-1,2,4-triazole based on nalidixic
acid [1-ethyl-3-(5-mercapto-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)-7-methyl-1,8-naphthyridin] (MTTN) 3
compound against CCl4 induced oxidative stress in mice.

Materials and Methods:

The MTTN compound was synthesized through the interaction and then
cyclization of p-tolylisothiocyanate with nalidixic acid hydrazide. By using 1
H-NMR, 13C-NMR, IR,
and elemental analyses, the structure of the newly synthesized MTTN compound was identified. To
investigate the hepatoprotective effect of this compound, forty BALB/c mice were divided into four
groups (n=10) as follows: the control group, the oxidative stress-induced group, which was
intraperitoneally injected with 10% CCl4 (2 mL/kg), one pre-treatment group, which was treated
orally with 200 mg/kg of MTTN compound for 8 days before being treated with CCl4 at day 8, and
one post-treatment group, which was treated orally with 200 mg/kg of MTTN compound for 8 days
simultaneously with CCl4 co-administration at days 3 and 5. At day 9, animals were scarified and
serum and liver samples were collected.

Results:

CCl4 administration caused significant hepatotoxicity as evidenced by marked elevation in
the serum activity of the liver enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and high blood cholesterol levels. Furthermore, the hepatic malondialdehyde (MDA)
level, a marker of lipid peroxidation, was increased with CCl4 administration that was associated
with a decrease in the hepatic superoxide dismutase (SOD) and catalase (CAT) activities (p < 0.05).
However, pre and post-treatment with the new newly synthesized MTTN compound significantly
reduced the serum levels of AST, ALT, and cholesterol and reduced hepatic oxidative stress as indicated by the decrease in the hepatic MDA level and the increases in the SOD and CAT activities (p <
0.05).

Conclusion:

This study suggests that the newly synthesized MTTN compound has a potent antioxidant property and can protect against CCl4-induced liver injury. Thus, with more clinical studies, this
compound may be used as effective therapeutic agents against oxidative stress related diseases.
Novel Approaches for Diagnosis and Herbal Treatment of Rheumatoid Arthritis - A Review
Authors: Nooreen Zulfa , Wal Pranay , Sachan Shivam , Wal Ankita , Rai Awani Kumar
Published: June 2024

Background:

Rheumatoid Arthritis is a chronic autoimmune disease that affects around
0.5% of the population. Limitations in movement may result from joint damage, which causes inflammation of the joint linings and the gradual deterioration of bone and cartilage.

Objective:

This article gives a summary of the current understanding of the potential pharmacological
processes of herbal drugs, risk factors, and innovative experimental approaches in the management
of rheumatoid arthritis.

Methodology:

A thorough literature search will be performed on five computerized databases, such
as PubMed, Google Scholar, Science Direct, Elsevier, and Wiley Online Library (WOL), for review
papers published between 1975 and 2023.

Results:

There are concerns about the current generation of potent synthetic rheumatoid arthritis
drugs, including toxic side effects and relapses in symptoms upon withdrawal from therapy. Because
of these constraints, RA patients are increasingly turning to herbal therapies. Due to the presence of
naturally occurring active components in medicinal plants, herbal treatments are utilized to reduce
arthritic pain and other symptoms.

Conclusion:

It emphasizes the growing significance of herbal medicines in the management of RA.
Several plants are mentioned in the research as potential treatments for RA because of their antiinflammatory properties.
A Perspective on Gastrointestinal Complications in COVID-19: Clinical
Features, Diagnosis, Research, Mechanisms, and Multidisciplinary
Management
Authors: Sahu Tarun , Pande Babita , Kumar Pramod , Khelkar Tuneer , Bhaskar LVKS , Verma Henu Kumar
Published: June 2024

The emergence of COVID-19 caused by SARS-CoV-2 has transformed our understanding
of the disease, transcending its initial characterization as a respiratory ailment. Acknowledged now
as a multisystem dysfunctional disorder, COVID-19 exhibits a diverse range of symptoms, notably
affecting the Gastrointestinal (GI) system. This article delves into the evolving comprehension of
COVID-19 as a multisystem disease, emphasizing its GI complications, including diarrhea, anorexia,
nausea, vomiting, and stomach discomfort. The exploration encompasses clinical features, diagnostic
methods, and research advancements related to COVID-19's impact on the GI system. It accentuates
the intricate link between gut and lung health, advocating a multidisciplinary approach for patients
with GI involvement. The review addresses innovative diagnostic techniques tailored for GI symptoms
and discusses emerging trends and breakthroughs in clinical research. Moreover, it analyzes the
mechanisms underpinning COVID-associated GI damage, emphasizing the interplay between gut
and lung pathophysiology, thereby deepening our understanding of the disease process. The article
proposes a comprehensive approach to managing COVID-19 patients with GI complications, advocating
stringent hygiene, detailed patient history analysis, consideration of preexisting conditions,
and exploration of various treatments, such as microbiome-targeted therapeutics, ACE2 inhibitors,
antibiotics, plasma therapy, and vaccines. Additionally, it highlights the role of nutritional supplements
and vitamins in supporting GI health during COVID-19. This content offers valuable insights
for clinicians, researchers, and policymakers, providing a roadmap for effective multidisciplinary
management tailored to GI manifestations in the COVID-19 pandemic. Through a thorough examination
of clinical aspects, diagnostics, mechanisms, and management strategies, this review contributes
significantly to the collective knowledge, enhancing our ability to combat COVID-19 comprehensively.
Prediction of Damage and Remaining Life of Yogyakarta-Bawen Toll Road Pavement with Elastic and Viscoelastic Approaches
Authors:   Civil Engineering Department, Universitas Islam Indonesia, 55584, Indonesia, Tolab Laziqoh Zahatul , Fauziah Miftahul ,   Civil Engineering Department, Universitas Islam Indonesia, 55584, Indonesia
Published: June 2024

Toll roads are one of the infrastructure development targets in Indonesia to speed up traffic and vehicle travel times. This paper analyzes the flexible pavement structure of the Yogyakarta-Bawen Toll Road. It predicts damage and residual values using elastic and viscoelastic approaches based on MDPJ Bina Marga 2017 using the KENPAVE Program. The recommended design alternative is pavement with a layer of AC-WC 40 mm, AC-BC 60 mm, Base AC 180 mm, and LPA 300 mm. This alternative is predicted to be able to serve load repetitions in the elastic approach of 432,857,828 ESAL until fatigue cracking occurs, 215,176,089 ESAL until rutting occurs, and 136,575,580 ESAL until permanent deformation occurs. Analysis using the viscoelastic approach can provide load repetitions of 153,304,378 ESAL until fatigue cracking occurs, 47,014,109 ESAL until rutting occurs, and 71,859,938 ESAL until permanent deformation occurs. Based on the elastic approach, the pavement's service life is 33 years, with initial damage in the form of permanent deformation. In comparison, the viscoelastic approach has a service life of 22.7 years, with initial damage in the form of rutting.
The Modeling Of Flood Inundation Distribution And The Institutional Index, Based On Hexahelix Collaboration, In The Downstream Of Tuntang Watershed
Authors:   Department of Civil Engineering, Universitas Diponegoro, 50275, Semarang, Sriyana Ignatius , Roselyn Melfina ,   Department of Civil Engineering, Universitas Diponegoro, 50275, Semarang, Wulandari Dyah Ari ,   Department of Civil Engineering, Universitas Diponegoro, 50275, Semarang
Published: June 2024

Flooding in the Tuntang Watershed of Central Java, Indonesia, poses a significant threat to communities and infrastructure. Past mitigation strategy have been ineffective due to fragmented collaboration, limited community involvement, and insufficient policy support. This study explores a new approach that combines the Village Watershed Model (VWM) and the hexahelix collaboration framework to promote coordinated action among government, communities, academia, businesses, NGOs, and media. This research create hydrological and hydraulic modeling, analyzing stakeholder roles, collaboration levels, and flood risks using questionnaires as a method. Results indicated moderate overall collaboration, with government and community leading the efforts. The hexahelix framework proved valuable for identifying strengths, weaknesses, and opportunities for improvement. Recommendations include strengthening coordination, enhancing community participation, fostering multi-stakeholder partnerships, developing comprehensive policies and funding mechanisms, and continuing research and innovation.
Sexual dysfunction in men and women with arterial hypertension
Authors: Kanorskii S. G.
Published: June 2024

Sexual dysfunction is often associated with hypertension but is not recognized, reported, or adequately treated. Research on sexual dysfunction is sparse, which may be due to the taboo nature of the topic. A literature search was conducted in five databases (PubMed, Web of Science, Scopus, Cochrane Library and PsycINFO) to identify articles published over the past ten years (from 2014 to 2024), using the keywords “sexual dysfunction”, “arterial” hypertension", "antihypertensive drugs", "erectile dysfunction". The review examines the prevalence, pathophysiology, clinical manifestations of sexual dysfunction in men and women, its relationship with arterial hypertension, antihypertensive therapy, concomitant pathology, and possible methods of correction.
NAFLD is a predictor of high risk of development and a co-factor in the progression of cardiovascular diseases
Authors: Shavkuta G. V. , Turkina S. V.
Published: June 2024

To date, nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver pathology and already at the stage of steatosis causes a high risk of developing cardiovascular diseases (CVD). Convincing evidence has been obtained that CVD is the most common cause of death in patients with NAFLD. Common risk factors (insulin resistance, abdominal obesity, dyslipidemia, hyperuricemia, chronic kidney disease and type 2 diabetes mellitus) and similar pathophysiological mechanisms (endothelial dysfunction, changes in lipid metabolism, systemic inflammation, plaque formation/instability, oxidative stress) of NAFLD and CVD, allow us to consider NAFLD not only as a key risk factor for the development of CVD, but also as a co-factor in the progression of cardiac pathology. The progression of NAFLD itself leads to a more severe course of CVD.
Assessment of adherence to therapy and options for polypharmacy in patients with CHF according to local registry data
Authors: Tarlovskaya E. I. , Omarova Y. V.
Published: June 2024

Objective: to study the frequency of adherence to therapy, as well as options for existing polypharmacy in patients with chronic heart failure (CHF) according to local registry data.

Materials and methods: the study included 398 patients with CHF aged 72.17±11.12 years. Patients were divided into groups depending on the type of polypharmacy (appropriate and inappropriate) according to the criteria of the EURO-FORTA (EF) system (2021) and based on national clinical guidelines (CR) (2020), without polypharmacy (taking 1–4 drugs during prehospital stage) who did not take therapy at the prehospital stage - during the last 3 months before the actual hospitalization.

Results: depending on the type of polypharmacy at the outpatient stage, the analysis was carried out by comparing 4 groups: appropriate (n=103 (EF) and n=120 (CR)) and inappropriate (n=103 (EF) and n=86 (CR) polypharmacy, without polypharmacy (taking 1-4 drugs) (n=91 (EF) and n=117 (KR)) and not taking therapy at the prehospital stage (n=55 (EF) and n=75 (KR)) during the last 3 months before current hospitalization. According to the Morisky-Green questionnaire, 38.44% were adherent to treatment at the prehospital stage, possibly adherent — 7.28%, non-adherent — 54.28%. The lowest quality of pharmacotherapy at the prehospital stage was observed in the group of patients without polypharmacy: they were less likely than patients with appropriate and inappropriate polypharmacy (according to the CR criteria) to take angiotensin-converting enzyme inhibitors (ACEIs) (30.77% versus 55.00% versus 51.16 %, рmg=0.0001), β-adrenergic blockers (β-AB) (52.13% vs. 88.33% vs. 77.90%, рmg=0.0001) and mineralocorticoid receptor antagonists (MCRA) (11.11 % versus 57.50% versus 52.32%, рmg=0.0001) and quite often in 30.77% (p=0.00001) they took potentially unacceptable medications, which further reduced the quality of therapy.

Conclusion: according to the Morisky-Green questionnaire, 54.28% of patients with CHF were non-adherent to therapy at the prehospital stage. Patients with CHF at the prehospital stage in 25.2% did not receive treatment for CHF, in 39.3% there was no polypharmacy and in 69.1% polypharmacy was observed. In multimorbid patients with CHF, polypharmacy had the following advantages: more frequent use of 3-component basic therapy for CHF, more frequent use of ACE inhibitors, β-blockers, AMCR, statins for coronary heart disease (CHD), oral anticoagulants (OAC) for fibrillation/flutter atria (AF/AFL) and antihyperglycemic therapy for diabetes mellitus (DM).
Visual Function and Driving Performance Under Different Lighting Conditions in Older Drivers: Preliminary Results From an Observational Study (Preprint)
Authors: Yang Jingzhen , Alshaikh Enas , Yu Deyue , Kerwin Thomas , Rundus Christopher , Zhang Fangda , Wrabel Cameron G , Perry Landon , Lu Zhong-Lin
Published: June 2024

BACKGROUND

Age-related vision changes significantly contribute to fatal crashes at night among older drivers. However, the effects of lighting conditions on age-related vision changes and associated driving performance remain unclear.

OBJECTIVE

This pilot study examined the associations between visual function and driving performance assessed by a high-fidelity driving simulator among drivers 60 and older across 3 lighting conditions: daytime (photopic), nighttime (mesopic), and nighttime with glare.

METHODS

Active drivers aged 60 years or older participated in visual function assessments and simulated driving on a high-fidelity driving simulator. Visual acuity (VA), contrast sensitivity function (CSF), and visual field map (VFM) were measured using quantitative VA, quantitative CSF, and quantitative VFM procedures under photopic and mesopic conditions. VA and CSF were also obtained in the presence of glare in the mesopic condition. Two summary metrics, the area under the log CSF (AULCSF) and volume under the surface of VFM (VUSVFM), quantified CSF and VFM. Driving performance measures (average speed, SD of speed [SDspeed], SD of lane position (SDLP), and reaction time) were assessed under daytime, nighttime, and nighttime with glare conditions. Pearson correlations determined the associations between visual function and driving performance across the 3 lighting conditions.

RESULTS

Of the 20 drivers included, the average age was 70.3 years; 55% were male. Poor photopic VA was significantly correlated with greater SDspeed (r=0.26; P<.001) and greater SDLP (r=0.31; P<.001). Poor photopic AULCSF was correlated with greater SDLP (r=–0.22; P=.01). Poor mesopic VUSFVM was significantly correlated with slower average speed (r=–0.24; P=.007), larger SDspeed (r=–0.19; P=.04), greater SDLP (r=–0.22; P=.007), and longer reaction times (r=–0.22; P=.04) while driving at night. For functional vision in the mesopic condition with glare, poor VA was significantly correlated with longer reaction times (r=0.21; P=.046) while driving at night with glare; poor AULCSF was significantly correlated with slower speed (r=–0.32; P<.001), greater SDLP (r=–0.26; P=.001) and longer reaction times (r=–0.2; P=.04) while driving at night with glare. No other significant correlations were observed between visual function and driving performance under the same lighting conditions.

CONCLUSIONS

Visual functions differentially affect driving performance in different lighting conditions among older drivers, with more substantial impacts on driving during nighttime, especially in glare. Additional research with larger sample sizes is needed to confirm these results.
Use of Machine Learning and Statistical Inference Methods for Identification of Risk Factors Associated with Atrial Fibrillation in Indian Patients: A Real-World Retrospective Study (Preprint)
Authors: Kulkarni Namrata , Taur Santosh , Aristeridou Danai , Shinde Salil , Spyridopoulos Konstantinos , Huda Ahsan , Dighe Sonali
Published: June 2024

BACKGROUND

Atrial Fibrillation (AF) is the most common type of cardiac arrhythmia in the general population. Machine Learning (ML) models can be utilized to identify the most pertinent risk factors and build reliable risk factor-based screening algorithms.

OBJECTIVE

The aim of current study was to evaluate ML in identifying risk factors associated with AF in Indian patients in tertiary care settings.

METHODS

This real-world, retrospective, observational, multicenter study was conducted by collecting data from anonymized Electronic Medical Records (EMRs) of patients between 1 Jan 2016 and 31 Dec 2019. The ML logistic regression model was used to calculate the Odds Ratio (OR) for identifying the risk factors.

RESULTS

A total of 5044 patients were included in the study; cohort of AF (cases; n=2516) and non-AF patients (controls; n=2528). The OR showed age above 65 years and female gender as risk factors for incident AF. Smoking, alcohol consumption, dyslipidemia, and hemiplegia, were strongly associated risk factors for AF with high ORs. Chronic diseases such as cardiac arrhythmia, paroxysmal tachycardia, rhematic heart disease, valvular heart disease, chronic obstructive pulmonary disease, stroke, surgery, neurological history, and hypothyroidism also emerged from the model as risk factors for developing incident AF. The model had an F1-score of 0.6930, predicting incident AF with an accuracy of 70.27% (accuracy=0.7027), sensitivity of 0.7042, and specificity of 0.7013. The model also had a positive predictive value of 0.6820 and a negative predictive value of 0.7230 with a threshold of 0.51 for the classification of true AF patients and an area under curve (AUC) of 0.7756.

CONCLUSIONS

The ML logistic regression model could be a useful predictive tool for incident AF that aids in AF risk management and individualized clinical decision-making.
Laboratory findings of postoperative venous thromboembolism (VTE) in Dr. Sardjito General Hospital, Yogyakarta
Authors: Supomo  , Mulyono Budi , Sukorini Usi , Arjana Adika Zhulhi , Novenanto Tandean Tommy
Published: June 2024

Venous thromboembolism (VTE) is a significant risk, especially for older individuals. Indonesian studies found 37.1% VTE incidence in bedridden patients over 40 and 2.1% in major surgeries. Surgery, like hip fractures, raises the risk temporarily. Diagnosis relies on tests like ultrasound with Doppler, Wells score, and neutrophil-to-lymphocyte ratio (NLR). This study aimed to evaluate the laboratory findings of postoperative VTE. A retrospective analysis was conducted in Dr. Sardjito General Hospital, Yogyakarta using medical record data of VTE patients who underwent major surgery. The laboratory data, including complete blood count characteristics for every month for three months after postsurgery and DVT presentation when it occurred on the diagnostic day were collected. In total of 27 patients involved in this study, VTE cases were more common in digestive (41.2%) and obstetric gynecology surgeries (29.4%) for females, and nervous (44.4%) and cardiovascular surgeries (22.2%) for males. Females had a higher prevalence of Well Score ≥3 (82.4% vs 40%; p=0.058) and longer VTE therapy durations (65.50 ± 46.51 vs 39.60 ± 41.04 d; p=0.172). Males had more unilateral VTE occurrences (90.9 vs 56.3%; p=0.070) and a higher proportion of total occlusion cases (60 vs 37.5%; p=0.422). NLR exhibited a significant decrease from the 1st to the 2nd month (10.52 vs 3.64; p=0.009), followed by an insignificant increase in the 3rd month (3.64 vs 3.98; p=0.878). Notably, NLR trended downward in the 2nd month examination. In conclusion, VTE occurs in 0.21% of postoperative patients, with the highest incidence observed in post-gynecological surgery patients. The NLR can serve as a diagnostic tool for VTE in extremities, as an elevated NLR indicates the presence of a more proximal thrombus.
Implementasi Program Pengelolaan Penyakit Kronis (Prolanis) di Masa Pandemi COVID-19 pada FKTP di Kota Malang
Authors: Purnamasari Ayu Tyas , Ningrum Herlinda Dwi
Published: June 2024

Penyakit kronis seperti hipertensi dan diabetes melitus tipe II menempati tiga penyakit tidak menular tertinggi di Indonesia yang dapat menyebabkan kematian. Pasien COVID-19 dengan komorbid hipertensi dan diabetes melitus tipe II berisiko mengalami gejala berat seperti gagal napas hingga kematian. Oleh karena itu, pelaksanaan kegiatan program pengelolaan penyakit kronis (Prolanis) selama masa pandemi tetap harus terlaksana melalui berbagai penyesuaian. Tujuan penelitian ini untuk mengeksplorasi bagaimana implementasi kegiatan Prolanis pada masa pandemi COVID-19 di FKTP di Kota Malang. Penelitian ini menggunakan metode kualitatif dengan teknik pengambilan data melalui wawancara mendalam, telaah dokumen, dan focus group discussion. Hasil penelitian menunjukkan aspek sumber daya manusia, sarana prasarana, anggaran, dan SOP di FKTP sudah memadai. Beberapa kegiatan mengalami perubahan selama pandemi, seperti kegiatan senam yang ditiadakan dan edukasi serta konsultasi medis dilaksanakan secara online untuk menghindari kerumunan. Output kegiatan Prolanis adalah terdapat Puskesmas yang sudah memenuhi capaian Rasio Peserta Prolanis Terkendali dan ada Puskesmas yang belum mencapai target tersebut.
EVALUASI PELAKSANAAN PROGRAM PENCEGAHAN DAN PENURUNAN STUNTING DI DESA LOKUS STUNTING KABUPATEN MERANGIN TAHUN 2022
Authors: Phitra Fajar Aria , Lipoeto Nur Indrawaty , Yetti Husna
Published: June 2024

Prevalensi balita stunting Kabupaten Merangin berdasarkan SSGI 2022 yaitu sebesar 14,5%. Angka ini sudah mengalami penurunan yaitu 19,7% pada tahun 2021. Untuk    mencapai target RPJMD Kabupaten Merangin 2019-2024 pada angka  9%  tahun 2024, maka laju penurunan prevalensi stunting harus ditingkatkan menjadi 3% per tahun. Target yang masih belum tercapai ini menjadi indikator masih perlu ditingkatkan kembali pelayanan yang diberikan kepada masyarakat melalui evaluasi input, proses dan output pada pelaksanaan program pencegahan dan penurunan stunting di desa lokus yang berhasil dan desa yang kurang berhasil menurunkan stunting. Penelitian ini merupakan suatu rancangan penelitian kebijakan. Metode penelitian kebijakan yang digunakan adalah metode deskriptif kualitatif dengan pendekatan input, proses dan output dalam evaluasi pelaksanaan program pencegahan dan penurunan stunting di desa yang berhasil dan kurang berhasil menggunakan wawancara semi struktur  (semi-sctructure interview) dan telaah dokumen. Hasil : komponen input, diketahui perbup stunting masih terdapat kekurangan muatan isi perbup yang mengacu pada prepres 72 tahun 2021.Ketenagaan ditingkat Kabupaten dan desa yang kurang berhasil masih kurang dan desa yang berhasil sudah mencukupi. Alokasi dana di tingkat Kabupaten belum memenuhi amanat dalam perka 12 tahun 2021 sebesar 10% dari APBD, sedangkan Desa yang berhasil dan kurang berhasil sudah memenuhi. Dilihat dari Proporsi anggaran intervensi spesifik jumlahnya jauh lebih rendah dibandingkan dengan intervensi sensitif, padahal intervensi spesifik dan sensitif berkontribusi masing-masing sebesar 70%:30% dalam menurunkan stunting.Sarana dan Prasarana, ketersedian tablet Fe untuk calon pengantin belum dialokasikan pengadaannya, Alat antropometri yang belum tersedia di semua posyandu. Metode, tidak tersedia buku pedoman. Komponen proses, Pelaksanaan konvergensi stunting di tingkat kabupaten dan Desa berhasil sudah melaksanakan berdasarkan juknis kemendagri dan perbup stunting sedangkan desa yang kurang berhasil belum sepenuhnya mengikuti pedoman. Sedangkan komponen output pada cakupan belum mencapai target yang ditetapkan, dan tahapan belum mengikuti pedoman yang ditetapkan pada desa kurang berhasil.
Inovasi Program Sejiwa dengan Jempol di Kecamatan Jabon Kabupaten Sidoarjo
Authors: Rodiyah Isnaini
Published: June 2024

Tujuan dari penelitian ini adalah untuk menganalisis dan mendeskripsikan inovasi layanan 'Sejiwa dengan Jempol' dan hambatan dari inovasi layanan tersebut di Puskesmas Jabon. Metode penelitian yang digunakan adalah deskriptif dengan pendekatan kualitatif. Pengumpulan data dilakukan melalui wawancara, observasi, dan dokumentasi. Informan kunci dalam penelitian ini adalah ketua coordinator program 'Sejiwa dengan Jempol'. Hasil penelitian menunjukkan bahwa inovasi pelayanan kesehatan melalui program Sejiwa dengan Jempol di Puskesmas Jabon telah dilakukan dengan adanya inisiatif dari Kepala Puskesmas Jabon melalui perjanjian kerjasama dengan Camat Jabon. Selain itu, sikap inovasi telah dibentuk melalui inisiatif Puskesmas Jabon untuk membentuk KBK (Kelompok Budaya Kerja) dari gugus bidang untuk memotivasi petugas. Kemampuan inovasi petugas dalam pelayanan kesehatan dibuktikan dengan upaya peningkatan pengetahuan dan keahlian dalam memahami Program 'Sejiwa dengan Jempol' melalui minilokakarya. Tim kerja dalam program ini menggabungkan lintas program terkait seperti Promkes KIA (Promosi Kesehatan Ibu dan Anak), gizi, gigi, lab, dan P2, serta membangun kemitraan lintas sektoral termasuk Camat Jabon, Kepala Desa, kader, Dispendukcapil, PKK, KUA, Polsek, dan Koramil. Kinerja inovasi Puskesmas dalam pelayanan program 'Sejiwa dengan Jempol' ditunjukkan dengan kunjungan ibu hamil yang meningkat 2 kali lipat, program P4K (Program Perencanaan Persalinan dan Pencegahan Komplikasi) berjalan secara otomatis, dan ibu hamil semakin sadar akan pentingnya BPJS. Saat ini ibu hamil mau tidak mau mencari donor darah sendiri. Intinya peran masyarakat menjadi lebih aktif, petugas hanya memotivasi saja. Melalui program tersebut, kasus ibu hamil yang berisiko tinggi dapat dicegah dan juga menurunkan angka kematian ibu dan bayi
Exploring the Ethical Dimensions of Mandatory Immunization Discourse for School Attendance in Indonesia
Authors: Marpaung Yosi Marin
Published: June 2024

Mandating complete vaccination for school attendance is still in the discourse for the future policy in Indonesia. Like any other policy, this discourse needs to be given an open space to be looked in a critical point view of ethic. This article critically examines the ethical dimensions surrounding the discourse of implementing mandatory immunization for school attendance in Indonesia, employing a multi-faceted ethical analysis. A case study utilizing moral reasoning through the lenses of utilitarianism, Kantian ethics, virtue ethics, and principlism was employed. From a utilitarian standpoint, mandatory vaccination is ethically justifiable, emphasizing its potential to yield substantial health benefits for society, reduce healthcare spending, and contribute to economic growth. The straightforward nature of this intervention, unlike other complex public health measures, makes it an appealing strategy for increasing vaccination coverage. However, Kantian, non-maleficence, and autonomy perspectives introduces ethical complexities, as mandatory immunization may be perceived as infringing upon individual beliefs and personal choice. The article advocates for open and honest discussions, understanding religious perspectives, and fostering trust in governmental decision-making to address these concerns. Virtue ethics are explored to underscore the importance of cultivating social responsibility in the success of public health measures. It further emphasizes the need for a just implementation of the policy, treating the specific needs of regions. In conclusion, the article posits that while the benefits of mandatory immunization are substantial, ethical considerations demand a delicate balance between promoting public health goals and respecting individual freedom. It suggests that achieving immunization targets necessitates a comprehensive approach, including respecting individual choices, building trust, widespread education on vaccine benefits and risks, and ensuring sustainable financing and vaccine procurement across all segments of Indonesia.
Analysis of Drug Management at Tegal City Pharmaceutical Installation
Authors: Al Yaqut Muhammad Arto , Satibi Satibi , Iswandi Iswandi
Published: June 2024

Background: Medicine is one of the most essential elements in health service efforts. Good drug management will affect the availability of drugs and improve the degree of health in the community.Objectives: This study aims to determine the effectiveness and efficiency of drug management at the Tegal City Pharmaceutical Installation in 2021 related to compliance with the Indonesian Ministry of Health and WHO indicators.Methods: This research is descriptive research with a quantitative approach. Data was taken retrospectively through document tracing and supplemented with qualitative data through interviews to deepen findings in the field. Data obtained and the results of interviews with the Head of Installation and pharmaceutical personnel, totaling five respondents, will then be compared with standard indicators from the Indonesian Ministry of Health and WHO. Data analysis in this study used indicators of selection, procurement, distribution, and use of drugs. The values of the indicators that have been obtained are subsequently compared with the existing standard values.Results: The results of drug management research at the Tegal City Pharmaceutical Installation are at the selection stage of proposing drugs to Fornas. The procurement stage of drug suitability with Fornas is 96.4%, the fund allocation percentage is 92%, and the planning accuracy is 95.7%. The distribution stage of the level of drug availability 12-18 is 13.92 months, the accuracy of the number of distributions to the Puskesmas is 100%, the percentage of drugs experiencing empty stock, dead stock, and overstock is 0%, the percentage of damaged and expired drugs is 0%. The use stage of drug items per prescription is 3.5 drug items, the percentage of antibiotic use in non-specific patients is 30.7%, the percentage of non-pneumonia Acute Respiratory Infections (ARI) antibiotic use is 34.2%, and myalgia injection use is 0%.Conclusion: The conclusion of drug management at the selection, procurement, distribution, and use stages in 2021 carried out at the Tegal City Pharmaceutical Installation has yet to follow standards. Of the 14 indicators studied, only 8 follow the standard, and 6 other indicators still need compliance to evaluation.
Exploration on Task-driven Teaching Design of Industrial Robot Operation and Programming Course in Secondary Vocational Schools
Authors: Simeng Cao , Yu Zhang
Published: June 2024

Currently, the national goal for the training of talents in vocational colleges and universities is to cultivate high-quality skilled talents with powerful practical ability, good thinking, and in line with the needs of the manufacturing industry. For the industrial robot operation and programming, which is a comprehensive practical training course with both theory and practice, focusing on the improvement of students' Introductory operation, offline programming ability, and familiarity with the use of network communication systems and other learning objectives, it is proposed to apply the "task-driven teaching method" throughout the whole teaching process to fully mobilize students' initiative and guide them to analyze the problems and improve their practical skills from different perspectives. The article focuses on the requirements of the course and discusses how to improve the student's capacity to apply theory in practice. The article focuses on the specific teaching design ideas of the task-driven teaching method and the multi-dimensional evaluation and assessment mode in this course in combination with the requirements of the course.
Evaluierung der Projektergebnisse der 5G-Playground Forschungsprojekte
Authors:   Technopolis Group | Austria, Giustolisi Alessio , Warta Katharina
Published: June 2024

Die vorliegende Evaluierung befasst sich mit den Use Cases innerhalb des "5G-Playground", einem Testlabor für die Forschung und Entwicklung von 5G-Anwendungen, Produkten, Prozessen und Applikationen. Die 5G-Playgrounds Carinthia wurden im Jahr 2019 gestartet und werden von der BABEG betrieben, deren Eigentümer der Bund und das Land Kärnten sind. Die Finanzierung erfolgte durch Mittel des Bundesministeriums und des Landes Kärnten. In Zusammenarbeit mit dem Mobilfunkanbieter A1 wurde die erforderliche Infrastruktur aufgebaut. Das übergeordnete Ziel der verschiedenen Use Cases bestand darin, Anwendungen im 5G-Netz auf ihre Funktionalität zu testen und vor allem die Effizienz des Netzes bis an seine Grenzen auszuloten. Die Wahl der verschiedenen Use Cases führte zu einem Dreieck-Konstrukt an (Grundlagen)Forschungsarbeiten, das die verschiedenen Herausforderungen der 5G-Technologien behandelte. Die drei Dimensionen sind die Verringerung der Latenzzeiten, die Bewältigung der Netzüberlastung durch eine hohe Anzahl von Endgeräten und die Unterstützung hoher Übertragungsraten. Diese Forschungsprojekte wurden im Jahr 2022 abgeschlossen, die Ergebnisse wurden nun einer Evaluierung unterzogen.
Comparative Study of Analytical Method Validation and Process Validation parameters as per ICH, EMA, WHO and ASEAN guidelines
Authors: Shah Devanshi , Movaliya Vinit , Kharidia Shruti , Zaveri Maitreyi
Published: June 2024

Objective: Compare and analyse analytical method validation and process validation requirements across ICH, EMA, WHO, and ASEAN guidelines, alongside relevant literature.
Summary: In the pharmaceutical industry, ensuring the quality, safety, and effectiveness of medicinal products is of utmost importance. Analytical Method Validation (AMV) and Process Validation (PV) are critical procedures in pharmaceutical manufacturing, vital for upholding product quality and adhering to regulatory standards. This thesis undertakes a comparative examination of AMV and PV guidelines from prominent regulatory authorities, including the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), the European Medicines Agency (EMA), the World Health Organization (WHO), and the Association of Southeast Asian Nations (ASEAN).
The study delves into the foundational principles, methodologies, and regulatory requirements outlined by each guideline to assess their alignment and differences. It scrutinizes key aspects such as validation parameters, acceptance criteria, documentation requirements, and statistical approaches to identify commonalities and disparities among the guidelines. Furthermore, this research aims to offer insights into the practical implications of adhering to multiple regulatory frameworks concurrently. It examines the challenges pharmaceutical companies encounter in navigating divergent requirements and harmonizing validation processes across various regions. Additionally, potential strategies to streamline compliance efforts and optimize resource allocation are explored.
By synthesizing the findings of this comparative analysis, stakeholders in the pharmaceutical industry can gain a comprehensive understanding of the regulatory landscape governing AMV and PV practices. Moreover, the insights derived from this study can inform the development of harmonized validation protocols that facilitate global market access while maintaining the highest standards of product quality and patient safety.
Conclusion: Notable variations exist in validation approaches, but all emphasize product quality, safety, and efficacy. Pharmaceutical companies must navigate diverse regulatory landscapes for compliance.
Technologies of physical and chemical impact on potato planting material
Authors: Zinoviev A. K. , Rembalovich, G. K. , Kostenko M. Yu.
Published: June 2024

The paper highlights that it is planned to increase the cultivation area of open ground vegetables and potatoes for ensuring the food security. (Research purpose) This study aims to explore methods and technologies for pre-planting treatment of potatoes. (Materials and methods) The research was conducted in the Tula region where Rannee Utro (Early Morning) and Rokko potato varieties were studied under natural infectious conditions. Various fungicides and biological products containing different active ingredients were applied to protect potatoes. Additionally, the study investigated the eff ects oflow-pressure mercury ultraviolet discharge lamps and magnetic field treatments on the biopotential and pH levels of potatoes. (Results and discussion) The study focuses on enhancing potato yields by applying direct magnetic field exposure before planting and investigates the impact of ultraviolet irradiation on tuber growth and productivity. Signifi cant emphasis was placed on the efficacy of chemical and biological agents in preventing potato scab. The findings show that optimal biometric indicators and potato yields were achieved with a magnetic induction of 30 millitesla. Any deviation from this treatment dose results in reduced biometric indicators and yields, which, however, remain hirer than those of the untreated controls. (Conclusions) The application of fungicidal disinfectants effectively curtails the development of common scab, with the highest efficacy achieved using Rovral Aquafl o 500. Post-treatment with ultraviolet radiation at a dose of 120-240 joules per square meter enhances vegetative growth, productivity, and tuber reproduction rates. The most favorable biometric indicators and yields were observed when a magnetic induction treatment dose of 0.23 joule-seconds per kilogram was applied.
Ibias, cubios y rubas
Authors: López Estupiñán Laura
Published: June 2024

Las evidencias arqueológicas en la cordillera de los Andes muestran una diversidad de alimentos adaptados y consumidos por sus pobladores. En Boyacá la investigación Alimentos prehispánicos, alimentos promisorios, realizada por el Grupo Interdisciplinario de Investigaciones Arqueológicas e Históricas de la Universidad Pedagógica y Tecnológica de Colombia (uptc), convenio Colciencias (2011- 2013), estudió los usos y saberes de diez alimentos identificados previamente en columnas de polen, fitolitos, almidones, carbones y relatos etnohistóricos. Para este artículo serán priorizados la Oxalis tuberosa, el Tropaeolum toberosum y el Ullucus tuberosus, por tratarse de alimentos con prácticas agrícolas particulares que evidencian relaciones recíprocas en la siembra, cosecha y consumo, las cuales serán descritas en innumerables recuerdos, formas de custodia y descripciones contenidas de sentires, apegos, cuidados y saberes en torno a la práctica del agricultar la tierra.
Do desejo à realidade de ser orientador de pesquisa na área da saúde
Authors: Kurachi Gustavo , Grosseman Suely
Published: June 2024

Qualitative case study, through semi-structured interviews with advisors in the health field, with the aim of understanding motivations, learning trajectory, needs and guidance practices. Two undergraduate and two graduate advisors were selected; subsequent selection was by snowball sampling. The guiding questions were: "What does being an advisor mean to you?"; "Please tell us how you learned to be an advisor?"; "What strategies do you use to guide research projects?"; "What are your needs as an advisor?". 14 advisors took part in the study, highlighting challenges related to inadequate training and to the relationship with advisees. The role of the advisor is seen as crucial, functioning as a guide and source of encouragement for students.
Malay-European Interfaith Discourse in Historical Perspective
Authors: Mohd Zarif Muhammad Mustaqim
Published: June 2024

As a multiracial country, Malaysia faces pressing trans-religious issues that could lead to tensions and conflicts if not properly managed. While acknowledging the importance of interfaith discourse and interreligious relations, current initiatives taken are yet to achieve its intended aims due to resistance from certain segments of the Muslims that viewed those initiatives as a direct threat to the supremacy of Islam in the country. At the same time, it is found that not much consideration is given to the social and historical experiences of the local populace in this matter, especially in the periods prior to the 20th century. Therefore, this paper aims to explore the nature of historical and social encounters between the Malay-Muslims and European Christians in terms of their perception and attitude towards other religions; identify cases of interfaith discourse and analyse its socio-political settings; and asses the role of the rulers and ulama in influencing the direction of interfaith discourse among the Malays. It is hoped that this historical reconstruction will help enrich our understanding of the nature, issues, and challenges faced today and charting the future direction of the interfaith dialogue in the country.
Illumination of Divine Love: Rediscovering the Hikmats of Sufi Ahmad Yasawi
Authors: Juraev Zuhriddin , Jin Ahn Young-
Published: June 2024

Divine love, rooted in religious and spiritual traditions, remains relevant today as it represents unconditional, selfless love and fosters empathy, compassion, and understanding among individuals. Embracing the principles of divine love can promote unity, tolerance, and interdependence, fostering global harmony and peace. This study uses a philosophical framework to examine the complex concept of divine love, specifically looking at the historical development and subtle meanings of love-related terms in Islamic Sufi literature. Special attention is given to Sufi poetry, specifically the works of the renowned mystic Shaykh Ahmad Yasawi and his 12th-century collection, Devon-i Hikmat or Hikmats, which are highly respected in Turkish culture. The research explores the stages of love and offers philosophical interpretations to understand the complex implications and profound nature of this concept. This study enhances our understanding of Sufi literature’s perspective on divine love by emphasizing its enduring significance as a universal and timeless facet of human experience that transcends temporal and cultural boundaries. Consequently, it fosters a profound understanding and appreciation for the enduring themes and cultural heritage found in Turkic Sufi poetry. The research highlights the lasting significance of divine love and the cultivation of deep respect for the timeless themes and rich cultural heritage found in Turkic Sufi poetry.
American and British Tolstoy: Reception in the End of the 19th — Beginning of the 20th Centuries
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Sergeeva Valentina S.
Published: June 2024

L.N. Tolstoy’s works, having been introduced to the English-reading audience, immediately became an issue of active critical discussions. British and American readers got acquainted with them differently than Russian ones —publications didn’t follow the chronological order, his fictional and philosophical books appeared simultaneously; the process of cultural transfer inevitably fragmented his work, took it out of context, and the readers in Britain and the USA perceived Tolstoy’s works in accordance with his image formed at the turn of the 19th–20th centuries. Besides the linguistic cultural barriers (it was necessary to work with Russian realities, facts of Russian life, make them clearer for foreign readers), translators and critics faced with other challenges — for example, they were to bring Tolstoy’s work into the circle of topics and subjects familiar to the English — reading public. Tolstoy entered the English speaking culture as a symbol of realism, which however didn’t mean hard naturalism, but rather ethical and psychological realistic writing, especially taking into account the ongoing discussion on Zola’s novels. Tolstoy’s realism was treated as a universal one, based on the well-known cultural and spiritual values and therefore especially significant in spite of the exotic subject matter of his works. The didactic nature of his work, its powerful moral appeal was obvious and strongly sought for in the period of heated argument about the social system, the problems of the industrial society, gender relations, etc., — despite the fact that some episodes were incompatible with Victorian or Puritan attitudes and tastes of his English-speaking readers.