bluuebunny/crossref_metadata_2025 huggingface dataset:
Kombucha: Perceptions and Future Prospects
Authors: Batista Patrícia , Penas Maria Rodrigues , Pintado Manuela , Oliveira-Silva Patrícia
Published: July 2022

Background: Kombucha is an increasingly consumed product classified as a nutraceutical. Legislative efforts about these products remain confusing and without global harmonization. This natural product has been developed to improve or promote physical and mental health. However, it needs regulatory guidelines to control the production and guarantee the product’s efficacy and safety. Aim: The study intends to draw attention to the need for regulatory guidelines and the potential of this product in the market and peoples’ health. Key findings and conclusions: The lack of regulation and the low level of literacy about this product can limit its development, marketing, and impact on health. Thus, it is essential to highlight the potential value of this product and invest in its development and marketing. Likewise, it is important to spread awareness among the population of these products and their impacts on people’s health. Thus, this study focuses on a pertinent theme and alerts to the need for legislation for these products, to draw attention to the inexistent legislative control and the consequent need for regulatory guidelines for better and safer production and consumption.
Application of a Newly Developed Chitosan/Oleic Acid Edible Coating for Extending Shelf-Life of Fresh Pork
Authors: Hoa Van-Ba , Song Dong-Heon , Seol Kuk-Hwan , Kang Sun-Moon , Kim Hyun-Wook , Kim Jin-Hyoung , Moon Sung-Sil , Cho Soo-Hyun
Published: July 2022

This study aimed at evaluating the applicability of a newly-developed chitosan/oleic acid edible coating for extending the shelf-life of fresh pork under aerobic-packaging conditions. Various coating formulations were used: 2% chitosan alone (CHI), 0.5% (v/v) oleic acid in 2% chitosan (CHI/0.5%OA) and 1% (v/v) oleic acid in 2% chitosan (CHI/1%OA) were prepared. For coating, fresh pork slices were fully immersed in the coating solutions for 30 s and dried naturally at 4 °C for 30 min. The coated samples were placed on trays, over-wrapped with plastic film, stored at 4 °C for 21 days, and were analyzed for shelf-life stability. Samples without coating were used as control. It was found that the aerobic bacteria and Pseudomonas spp. counts, and total volatile basic nitrogen (TVBN) content were almost two to three times lower in the CHI/OA-coated samples compared to the control after 21 days of storage (p < 0.05). The CHI/OA coating combination completely inhibited growth of E. coli, and protected the meat from discoloration after 21 days of storage. In particular, the addition of OA increased the concentration of volatiles associated with pleasant aromas. This study provides an application potential of chitosan/oleic acid edible coating in preservation of fresh pork to prolong the shelf-life and improve safety.
Analysis of the Physical and Structure Characteristics of Reformulated Pizza Bread
Authors: Alam Syed Saif , Bharti Deepti , Pradhan Bikash K. , Sahu Deblu , Dhal Somali , Kim Nahyun Mariah , Jarzębski Maciej , Pal Kunal
Published: July 2022

The current study deciphers the processing of different proportions of white flour and whole wheat flour (100:0, 75:25, 50:50: 25:75, and 0:100) into a pizza base using yeast-based fermentation. The bread making using the yeast system resulted in significant changes in the characteristics of bread, ranging from the porous structure development to the crumb cellular structure modifications. An increase in the proportions of whole wheat flour resulted in the formation of golden yellow pizza bases. The lightness of the crust was decreased, whereas the yellowness index was increased as the whole wheat flour contents were increased. The pore size of the pizza base was decreased while the pore density was increased as the whole wheat flour content was raised within the bread. The microscopic study also showed the formation of porous structures on the bulk of the pizza base. The texture analysis of the bread also suggested an increase in the formation of the rigid network structure when the amount of whole wheat flour was increased. The springiness, cohesiveness, and resilience were comparable for all the prepared samples. On the other hand, the values for hardness, gumminess, and chewiness showed an increasing trend with the increase in the whole wheat flour content. The impedance of the samples decreased when there was an increase in the whole wheat flour content. Overall, the pizza base that was developed with 50% whole wheat flour and 50% white flour ratio displayed acceptably firm yet sufficient viscoelastic properties for human consumption.
Clinical Features and Genetic Findings of Autosomal Recessive Bestrophinopathy
Authors: Kim Hae Rang , Han Jinu , Kim Yong Joon , Kang Hyun Goo , Byeon Suk Ho , Kim Sung Soo , Lee Christopher Seungkyu
Published: July 2022

Autosomal recessive bestrophinopathy (ARB) is a rare subtype of bestrophinopathy caused by biallelic mutations of the BEST1 gene. ARB is characterized by multifocal subretinal deposits accompanied by macular edema or subretinal fluid, hyperopia, co-existing narrow angle, and a marked decrease in electrooculogram. However, little is known about the genetic variants and specific clinical features of ARB. This is an observational case series of patients with a clinical and genetic diagnosis of ARB who underwent multimodal imaging. We describe ten patients from nine unrelated families with six known variants and three novel missense variants: c.236C→T, p.(Ser79Phe); C.452C→T, p.(Leu151Pro); and c.650C→T, p.(Trp217Met). The most common variant was c.584C→T, p.(Ala195Val), observed in six patients, without correlation to the severity of the phenotype. All patients manifested bilateral multifocal subretinal deposits and subretinal fluid throughout the follow-up period, while intraretinal fluid was found in approximately half of the eyes. The extent or chronicity of the fluid collection did not correlate with visual acuity. Angle-closure glaucoma was present in five eyes. Three patients had a genetically confirmed family history of ARB, and one patient had a clinically suspected family history. This study reveals novel mutations in the BEST1 gene and adds to the spectrum of clinical presentations of ARB.
Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib
Authors: Al-Ansari Sali , Jalali Rozita , Bronckers Antonius L. J. J. , van Tellingen Olaf , Raber-Durlacher Judith , Nadjmi Nasser , Brook Alan Henry , de Lange Jan , Rozema Frederik R.
Published: July 2022

Background: Chemotherapy treatment of cancer in children can influence formation of normal tissues, leading to irreversible changes in their structure and function. Tooth formation is susceptible to several types of chemotherapy that induce irreversible changes in the structure of enamel, dentin and dental root morphology. These changes can make the teeth more prone to fracture or to caries when they have erupted. Recent studies report successful treatment of brain tumors with the alkylating drug temozolomide (TMZ) in combination with veliparib (VLP) in a glioblastoma in vivo mouse model. Whether these drugs also affect tooth formation is unknown. Aim: In this study the effect of TMZ/VLP on incisor formation was investigated in tissue sections of jaws from mice and compared with mice not treated with these drugs. Materials and method: The following aspects were studied using immunohistochemistry of specific protein markers including: (1) proliferation (by protein expression of proliferation marker Ki67) (2) a protein involved in paracellular ion transport (expression of tight junction (TJ) protein claudin-1) and (3) in transcellular passage of ions across the dental epithelium (expression of Na+, K+ 2Cl- cotransporter/NKCC1). Results: Chemotherapy with TMZ/VLP strongly reduced immunostaining for claudin-1 in distal parts of maturation ameloblasts. No gross changes were found in the treated mice, either in cell proliferation in the dental epithelium at the cervical loop or in the immunostaining pattern for NKCC1 in (non-ameloblastic) dental epithelium. The salivary glands in the treated mice contained strongly reduced immunostaining for NKCC1 in the basolateral membranes of acinar cells. Discussion/Conclusions: Based on the reduction of claudin-1 immunostaining in ameloblasts, TMZ/VLP may potentially influence forming enamel by changes in the structure of TJs structures in maturation ameloblasts, structures that are crucial for the selective passage of ions through the intercellular space between neighboring ameloblasts. The strongly reduced basolateral NKCC1 staining seen in fully-grown salivary glands of TMZ/VLP-treated mice suggests that TMZ/VLF could also influence ion transport in adult saliva by the salivary gland epithelium. This may cause treated children to be more susceptible to caries.
Assessment of the Bacterial Loads of Vacuum-Thermoformed Removable Retainers (VTRR) in Patients under Retention Therapy: A Randomized Clinical Trial
Authors: Butera Andrea , Gallo Simone , Pascadopoli Maurizio , Sfondrini Beatrice , Alovisi Mario , Marya Anand , Stablum Giulia , Scribante Andrea
Published: July 2022

Retention devices are essential after orthodontic treatment in order to avoid the risk of relapse. For this goal, vacuum-thermoformed removable retainers (VTRRs) are useful tools in clinical practice. The main limitation related to them is the accumulation of plaque. The aim of this study was to investigate the bacterial loads present on VTRRs (Essix ACE Plastic, Dentsply Sirona) in patients under retention therapy. Patients were randomly divided into three groups, depending on the product used for the cleansing of the VTRR: Geldis, Polident tablets, and simple water, respectively. Microbiological samples were taken from the retainers at the baseline, after 1 and after 2 months, with the collection of Bleeding on Probing (BoP), Plaque Index (PI), Basic Erosive Wear Examination (BEWE) and Schiff Air Sensitivity test (SAI). A total of 15 patients were recruited and for each product, 5 patients were allocated. No significant intragroup and intergroup differences were observed at any time point for PI, SAI, BoP, Red Complex, Total Pathogen and Total Saprophyte loads. A significant intragroup and intergroup difference was assessed at T1 and T2 for BEWE in the control group. According to the results of this study, the bacterial load on VTRR retainers is not influenced by the cleaning methods tested.
A Remote Assessment of Anxiety on Young People: Towards Their Views and Their Different Pet Interaction
Authors: Giansanti Daniele , Siotto Mariacristina , Maccioni Giovanni , Aprile Irene
Published: July 2022

The lockdown was imposed in Italy on 9 March 2020 due to the COVID-19 outbreak. Restrictions severely limiting individual freedom were indispensable to protect the population and reduce virus diffusion. Italian people had never before experienced similar restrictions that undoubtedly tested psychological health. After 1 week, we developed an electronic survey to collect demographic data and information on the presence of pets and the type of interaction with them and to administer a self-assessment anxiety test. A total of 3905 subjects, pet owners and non pet owners, filled in the electronic survey; 652 (16.7%, mean age 21.6) of them were young subjects, adolescents, and university students. The study first showed the feasibility and success of the technological solution used, capable of providing, at a distance, structured information on the participants and quantitative data on the psychological condition. Second, it reported that 23.1% of the youths showed anxiety above an attention level during the lockdown, in line with other studies. Third, it indicated, based on the outcome of the self-assessment test, that the pet presence could have a positive effect in mitigating the psychological impact and encourage to continue and deepen these investigations. Fourth, it reported positive feedback from the participants on the procedure, found useful during the pandemic and for the post-pandemic future. The study highlights the importance of investing in these solutions based on mobile technology and useful both for mental health and to deepen the investigation of the impact of the pet presence on the human psychology.
Psychosocial Intervention Cultural Adaptation for Latinx Patients and Caregivers Coping with Advanced Cancer
Authors: Torres-Blasco Normarie , Costas-Muñiz Rosario , Rosario Lianel , Porter Laura , Suárez Keishliany , Peña-Vargas Cristina , Toro-Morales Yoamy , Shen Megan , Breitbart William , Castro-Figueroa Eida M.
Published: July 2022

Latinx advanced cancer patients and caregivers are less likely to have adequate access to culturally congruent psychosocial interventions. Culturally relevant and adapted interventions are more effective within minority groups. We obtained patients’ and caregivers’ initial evaluations of the Caregivers–Patients Support to Latinx coping with advanced-cancer (CASA) protocol. A qualitative study was conducted, and an acceptance questionnaire and semi-structured interviews were conducted to culturally adapt the psychosocial intervention for Latinx coping with cancer. The semi-structured interview described and demonstrated intervention components and elicited feedback about each one. Latinx advanced cancer patients (Stage III and IV) and caregivers (n = 14 each) completed the acceptance survey, and N = 7 each completed semi-structured interviews. A total of 12 of the 14 patients and caregivers (85.7%) reported high acceptance of the goals and purposes of the intervention protocol. They also reported willingness to daily use of the content of the intervention components: Communication Skills, the Willingness of Meaning, Life has Meaning, Freedom of Will, Identity, Creative Sources of Meaning, and Homework. Most of the participants reported high acceptance (n = 9) of integrating family caregivers into therapy and the high acceptance (n = 10) of the length of the 4-session intervention.
Assessing Smoking Status and Risk of SARS-CoV-2 Infection: A Machine Learning Approach among Veterans
Authors: Nono Djotsa Alice B. S. , Helmer Drew A. , Park Catherine , Lynch Kristine E. , Sharafkhaneh Amir , Naik Aanand D. , Razjouyan Javad , Amos Christopher I.
Published: July 2022

The role of smoking in the risk of SARS-CoV-2 infection is unclear. We used a retrospective cohort design to study data from veterans’ Electronic Medical Record to assess the impact of smoking on the risk of SARS-CoV-2 infection. Veterans tested for the SARS-CoV-2 virus from 02/01/2020 to 02/28/2021 were classified as: Never Smokers (NS), Former Smokers (FS), and Current Smokers (CS). We report the adjusted odds ratios (aOR) for potential confounders obtained from a cascade machine learning algorithm. We found a 19.6% positivity rate among 1,176,306 veterans tested for SARS-CoV-2 infection. The positivity proportion among NS (22.0%) was higher compared with FS (19.2%) and CS (11.5%). The adjusted odds of testing positive for CS (aOR:0.51; 95%CI: 0.50, 0.52) and FS (aOR:0.89; 95%CI:0.88, 0.90) were significantly lower compared with NS. Four pre-existing conditions, including dementia, lower respiratory infections, pneumonia, and septic shock, were associated with a higher risk of testing positive, whereas the use of the decongestant drug phenylephrine or having a history of cancer were associated with a lower risk. CS and FS compared with NS had lower risks of testing positive for SARS-CoV-2. These findings highlight our evolving understanding of the role of smoking status on the risk of SARS-CoV-2 infection.
Adaptability, Interdisciplinarity, Engageability: Critical Reflections on Green Social Work Teaching and Training
Authors: Wu Haorui , Greig Meredith
Published: July 2022

The upward tendencies of global climate change, disasters, and other diverse crises have been urgently calling for green social work (GSW) interventions which engage a holistic approach to explore diverse societal dimensions’ compounded influences on inhabitants’ individual and collective health and well-being in disaster settings. Though globally gaining more attention, GSW has been slow to develop in the Canadian social work curriculum and professional training. This deficit jeopardizes integrating environmental and climate justice and sustainability in social work research and practice in Canada. In response to this pedagogical inadequacy, this article employs a critical reflection approach to examine two authors’ two-academic-year teaching–learning and supervision-training experiences of GSW-specific in-class and field education in a Master of Social Work program. The content analysis illustrates three essential components for GSW-specific teaching and training, namely adaptability, interdisciplinarity, and engageability. These components enhance the prospective social workers’ micro-, mezzo-, and macro-level practices to better support individuals, families, and communities affected by extreme events and promote their health and well-being in disaster and non-disaster scenarios. These GSW-specific pedagogies shed light on the fact that integrading climate change, disasters, and diverse crises in pedagogical innovations should be encouraged beyond the social work profession. A multidisciplinary multi-stakeholder engagement approach would comprehensively investigate and evaluate the essential components and evidence-based strategies that better serve inhabitants and promote resilience and sustainability.
Neurocysticercosis in Low- and Middle-Income Countries, a Diagnostic Challenge from Oyam District, Uganda
Authors: Segala Francesco Vladimiro , De Vita Elda , Amone James , Ongaro Daniel , Nassali Ritah , Oceng Bonny , Okori Samuel , Putoto Giovanni , Lochoro Peter , Ictho Jerry , Fantoni Massimo , Saracino Annalisa , Di Gennaro Francesco
Published: July 2022

Background: In countries where Taenia solium is endemic, neurocysticercosis (NCC) is the leading identified cause of seizures, accounting for nearly 30% of all epilepsy cases and up to 2.8 million of Disability Adjusted Life Years. Diagnosis of this condition, however, is strictly reliant on either MRI or CT scan, which are poorly available in low- and middle-income countries (LMICs), creating challenges for proper case management and the acquisition of precise neuroepidemiologic data that may guide program and policy development. Methods: Here, we report the case of a 73-year-old woman admitted in a rural hospital in Northern Uganda, who presented with seizures and a progressive inability to walk. She was then diagnosed with NCC after a brain CT scan. Conclusions: This case study represents a rare example of the detection of NCC in a rural district hospital, thus suggesting the potential feasibility of a CT-scan guided diagnostic approach in low resource settings.
Inanimate Surfaces as a Source of Hospital Infections Caused by Fungi, Bacteria and Viruses with Particular Emphasis on SARS-CoV-2
Authors: Jabłońska-Trypuć Agata , Makuła Marcin , Włodarczyk-Makuła Maria , Wołejko Elżbieta , Wydro Urszula , Serra-Majem Lluis , Wiater Józefa
Published: July 2022

The carriers of nosocomial infections are the hands of medical personnel and inanimate surfaces. Both hands and surfaces may be contaminated as a result of contact with the patient, their body fluids, and touching contaminated surfaces in the patient’s surroundings. Visually clean inanimate surfaces are an important source of pathogens. Microorganisms have properties thanks to which they can survive in unfavorable conditions, from a few days to several months. Bacteria, viruses and fungi are able to transmit from inanimate surfaces to the skin of the patient and the medical staff. These pathogens include SARS-CoV-2, which can survive on various types of inanimate surfaces, being a potential source of infection. By following the recommendations related to washing and disinfecting hands and surfaces, and using appropriate washing and disinfecting agents with a broad biocidal spectrum, high material compatibility and the shortest duration of action, we contribute to breaking the chain of nosocomial infections.
The Implication of Physically Demanding and Hazardous Work on Retirement Timing
Authors: Stengård Johanna , Virtanen Marianna , Leineweber Constanze , Westerlund Hugo , Wang Hui-Xin
Published: July 2022

The need to retain individuals longer in the workforce is acknowledged in many high-income countries. The present study therefore aimed to examine the importance of physically demanding work tasks (PDWT) and physically hazardous work environment (PHWE) in relation to retirement timing among pensionable workers (≥61 years). A particular question was whether PDWT and PHWE increased in importance with age. Six waves (2008–2018) of the Swedish Longitudinal Occupational Survey of Health (SLOSH) were used (n = 5201; 56% women and 44% men; mean age at first survey was 61.0 (SD 2.0) years). Discrete time-event history analysis, stratified by socioeconomic position and gender, showed that among blue-collar workers, PDWT and PHWE were associated with an increased likelihood of retiring within the next two years. With increasing age, high-level PHWE was associated with higher probability of retiring among blue-collar men, whereas heavy PDWT was associated with lower probability of retiring among blue-collar women. Among white-collar workers, having at least some PDWT compared to no PDWT was associated with a lower likelihood of retiring within the next two years. With increasing age, exposure to PHWE was associated with higher probability of retiring among white-collar women. These results suggest that to delay retirements, organizations could offer their older employees, especially blue-collar workers and the oldest white-collar women, alternatives to PDWT and PHWE.
Addressing Food Insecurity during the COVID-19 Pandemic: Intervention Outcomes and Lessons Learned from a Collaborative Food Delivery Response in South Florida’s Underserved Households
Authors: Garba Nana Aisha , Sacca Lea , Clarke Rachel D. , Bhoite Prasad , Buschman John , Oller Virama , Napolitano Nancy , Hyppolite Samuel , Lacroix Sophia , Archibald Al , Hamilton Ocean , Ash Tobi , Brown David R.
Published: July 2022

Background: The COVID-19 pandemic highlighted underlying disparities in health, healthcare access, and other social factors that have been documented for racial/ethnic minorities. The social-distancing mandate exacerbated the impact of social determinants of health, such as unemployment and food insecurity, particularly among underserved minority populations. We highlight intervention outcomes and lessons learned from the Florida International University (FIU) Herbert Wertheim College of Medicine (HWCOM) NeighborhoodHELP’s response to pandemic-related food insecurity among Miami Dade County’s underserved population. Methods: Following the stay-at-home mandate, a weekly needs assessment of program households was conducted by the NeighborhoodHELP team, during which food insecurity emerged as a pandemic-related urgent need, rising from three percent of program Households in March 2020 to 36.9 percent six months later. Consequently, the program staff collaborated with another FIU department, community partners, and a benefactor to develop a food donation and delivery project. Results: Fifteen hundred and forty-three culturally appropriate food boxes were delivered to 289 participating households, comprising 898 household members, over a 14-month period. Conclusion: This project underscores the importance of leveraging community assets to address their needs during a crisis and the significance of sustained community engagement for researchers and service providers who work in underserved communities.
High-Intensity Interval Training for Rowing: Acute Responses in National-Level Adolescent Males
Authors: Faelli Emanuela , Panascì Marco , Ferrando Vittoria , Codella Roberto , Bisio Ambra , Ruggeri Piero
Published: July 2022

Background: This study investigated the acute effects of two high-intensity interval training (HIIT) programs on physiological responses and internal workload. Methods: Ten national-level adolescent male rowers (age: 15.7 ± 0.2 years; maximal oxygen uptake (VO2max): 60.11 ± 1.91 mL∙kg−1∙min−1) performed two HIIT testing sessions: short (S-HIIT) and long (L-HIIT). In S-HIIT, the rowers performed 25 reps of 30 s at 100% power at VO2max (Pmax) interspersed with 30 s at P@20% Pmax; whereas in L-HIIT, the rowers executed 4 × 4 min at P@90% Pmax interspersed with 3 min of active recovery (P@30% Pmax). Results: The acute physiological responses and internal workload were evaluated. The significance level was set at p < 0.05. Oxygen uptake (VO2) (p < 0.05), time spent per session at ~90% VO2max (p < 0.01), total VO2 consumed (p < 0.01), total distance (p < 0.001), the rating of perceived exertion, blood lactate concentration and heart rate (always p < 0.0001) were significantly higher in L-HIIT than in S-HIIT. However, peak power output was significantly lower in L-HIIT compared to S-HIIT (p < 0.0001). Conclusion: In adolescent rowers, both HIIT tests stimulated aerobic and anaerobic systems. The L-HIIT test was associated with acute cardiorespiratory and metabolic responses, as well as higher perceptions of effort than the S-HIIT test. In adolescent rowers, HIIT emerges as an asset and could be introduced into a traditional in-season, moderate-intensity and endurance-based rowing program once a week.
Fractional Ablative Carbon Dioxide Lasers for the Treatment of Morphea: A Case Series and Literature Review
Authors: Klimek Paulina , Placek Waldemar , Owczarczyk-Saczonek Agnieszka
Published: July 2022

Morphea is an inflammatory, immune-mediated disease of unknown aetiology. It is characterised by excessive collagen deposition, which leads to the hardening of the dermis and subcutaneous tissues. The disease is associated with cosmetic and functional impairment, which can affect the patients’ quality of life. Fractional ablative lasers (FALs) are currently used for the treatment of many skin diseases that are connected to tissue fibrosis due to the low risk of side effects and their great effectiveness. This study aimed to improve the aesthetic defects that are caused by morphea lesions and assess the efficacy and safety of FAL use in this indication. We also reviewed the literature on the subject. We present four women with biopsy-proven morphea, manifesting as hyperpigmented plaques and patches. One of the patients additionally had morphea-related knee joint contracture. Four fractional CO2 laser sessions, separated by one-month intervals, were performed and produced significant improvements in dyspigmentation and induration. An improved elasticity and a decrease in dermal thickness were also obtained, as proven by measurements using DermaLab Combo. No severe adverse effects occurred. Based on these cases presented by the authors, fractional CO2 lasers appear to be an effective, well-tolerated, and safe therapeutic option for patients suffering from morphea.
Association between Type 2 Diabetes and Classification of Periodontal Disease Severity in Japanese Men and Women: A Cross-Sectional Study
Authors: Dewake Nanae , Iwasaki Yukiko , Taguchi Akira , Udagawa Nobuyuki , Yoshinari Nobuo
Published: July 2022

Background: to evaluate the association between type 2 diabetes and periodontal disease severity using the rate of alveolar bone loss (ABL) and high-sensitivity C-reactive protein (hs-CRP) value as indices. Methods: In this cross-sectional study of 372 patients (mean age ± SD, 53.2 ± 11.8 years) from a Japanese hospital, we measured ABL and number of teeth on either panoramic radiographs or intraoral dental radiographs of all teeth. Periodontal disease severity was classified into nine groups by combining ABL and hs-CRP. Results: 48 subjects had type 2 diabetes; 324 did not. Univariate analysis showed that type 2 diabetes was significantly associated with age, sex, body mass index, number of teeth, ABL, hs-CRP, and periodontal disease severity. Multivariate analysis showed significant associations between type 2 diabetes and the groups with high severity of periodontal disease. In receiver operating characteristic (ROC) curve analysis, predicting the presence of diabetes, area under the ROC curve was 0.762 (95%CI = 0.688–0.835) for ABL, and 0.709 (95%CI = 0.635–0.784) for hs-CRP, which was significant. Conclusions: this study showed that diabetes can be associated with a periodontal disease severity classification using the combination of ABL and hs-CRP.
Quantitative Changes in Various Nutrient Ratios in Fodder Plants as an Effect of Compost and Fly Ash Application
Authors: Jakubus Monika , Graczyk Małgorzata
Published: July 2022

Despite the popularity of concentrated feed, fodder crops are still important, especially in organic livestock farming. However, this type of feed must meet certain criteria, which are often described using correct nutrient ratios. The research investigates the influence of compost and fly ash on quantitative changes in nutrient ratios determined for lupine and oat cultivated on soil slightly contaminated with Cu. A pot experiment was conducted on medium soil. Immobilizing agents (compost and fly ash) were applied at the dose of 40 t per ha. Plant materials were subjected to chemical analyses to assess their macronutrient content and, based on these data, mutual proportions of individual nutrients were calculated as mass ratios of K:Mg, K:Na, Ca:P, Ca:Mg, K:(Ca+Mg) and (K+Na):(Ca+Mg). Changes in ratio values were visualized using statistical tools, i.e., Anova, correlation coefficients and dendrograms. It was found that immobilizing agents constituted a source of the chosen nutrients because their amounts in plants grown on the soil fertilized with either compost or fly ash compost were significantly higher than in the control plants. This phenomenon was especially visible with regard to Ca and Mg for both lupine and oat. It should be emphasized here that the effect of compost or fly ash on the content of Ca and K in plants was comparable. In general, the application of compost contributed to higher values of the analyzed nutrients in both plants. The control and fertilized fly ash plants were characterized by lower values of nutrient ratios. The expected optimal value range of 2–3:1 was determined only for Ca:Mg, which was found in both lupine and oats. The proper values of K:Mg (2–6:1) were found only in the case of fodder plants cultivated on soil amended with compost.
Effects of Job Demands and Resources on Positive and Negative Affect of Delivery Drivers in China
Authors: Zhang Congcong , Sitar Sophie , Huang Chien-Chung
Published: July 2022

The delivery workforce in China has grown substantially within the past decade. As this industry has grown, job demands (JD) have also increased to ensure productivity. Accordingly, delivery drivers are increasingly facing volatile and stressful work conditions that could influence their Positive and Negative Affect (PANA), which has been an important predictor of their health and well-being. This study utilizes a sample of modern delivery drivers in Beijing, China (n = 240) to study how the job demands-resources theory (JD-R) was related to PANA. The results indicate delivery drivers experience relatively high JD and moderate JR at their places of employment. As expected, JR were positively associated with PA and negatively associated with NA. Meanwhile, JD were positively related to NA; however, JD were also positively associated with PA within the sample. Further interaction analysis showed that only drivers with high JD and high JR were positively associated with PA and that drivers with high JD and low JR were associated with high NA and had no effect on PA. These findings call for support for Chinese delivery drivers who face high job stress and high job demands.
Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study
Authors: Manley Cherrel K. , Villanger Gro D. , Thomsen Cathrine , Cequier Enrique , Sakhi Amrit K. , Reichborn-Kjennerud Ted , Herring Amy H. , Øvergaard Kristin R. , Zeiner Pal , Roell Kyle R. , Engel Lawrence S. , Kamai Elizabeth M. , Thistle Jake , Hall Amber , Aase Heidi , Engel Stephanie M.
Published: July 2022

Prenatal organophosphorus pesticide (OPP) exposure has been associated with child attention-deficit/hyperactivity disorder (ADHD) in agricultural communities and those that are exposed to residentially applied insecticides. To examine this association in populations that are exposed primarily through diet, we estimate the associations between prenatal OPP exposure and preschool ADHD in the Norwegian Mother, Father and Child Cohort Study (MoBa), and describe modification by paraoxonase 1 (PON1) gene variants. We used participants from the MoBa Preschool ADHD Sub-study (n = 259 cases) and a random sample of MoBa sub-cohort participants (n = 547) with birth years from 2004 to 2008. Prenatal urinary dialkylphosphate (DAP) metabolites (total diethylphosphate [∑DEP] and total dimethylphosphate [∑DMP]) were measured by an ultra-performance liquid chromatography-time-of-flight system and summed by molar concentration. Maternal DNA was genotyped for coding variants of PON1 (Q192R and L55M). We used a multivariable logistic regression to calculate the odds ratios (OR) and 95% confidence intervals, adjusted for maternal education, parity, income dependency, age, marital status, ADHD-like symptoms, pesticide use, produce consumption, and season. We found no associations between DAP metabolite concentrations and preschool ADHD. The adjusted ORs for exposure quartiles 2–4 relative to 1 were slightly inverse. No monotonic trends were observed, and the estimates lacked precision, likely due to the small sample size and variation in the population. We found no evidence of modification by PON1 SNP variation or child sex. Maternal urinary DAP concentrations were not associated with preschool ADHD.
Cytokine Profile in Patients with Multiple Sclerosis Following Exercise: A Systematic Review of Randomized Clinical Trials
Authors: Najafi Parisa , Hadizadeh Maryam , Cheong Jadeera Phaik Geok , Mohafez Hamidreza , Abdullah Suhailah
Published: July 2022

Multiple sclerosis (MS) is one of the most prevalent causes of nontraumatic neurological impairment in young adults. This review aims to determine the impact of exercise on cytokine and adipokine profile levels as inflammatory markers in MS patients across various exercise paradigms. We used specific keywords in PubMed, Web of Science, The Cochrane Library, and Scopus to find randomized clinical trials addressing the effects of physical activity and exercise training on inflammatory markers levels in MS patients. The majority of the research showed no considerable changes in IL-6 levels, while three studies reported declining levels after the intervention. Approximately half of the trials observed a change in TNF-α and IL-10 levels after exercise interventions, while the other half showed no meaningful changes. Other markers such as IL-17, IL-4, IL-12, adipokines, and BDNF showed fluctuations in levels. We found no universal agreement on the effects of different exercise training protocols on the serum level of inflammatory markers in patients with MS. More research is needed to fully identify the effects of exercise on cytokines in MS patients.
A Bibliometric Analysis of the Scientific Research on Artisanal and Small-Scale Mining
Authors: Morante-Carballo Fernando , Montalván-Burbano Néstor , Aguilar-Aguilar Maribel , Carrión-Mero Paúl
Published: July 2022

Mineral resource exploitation is one of the activities that contribute to economic growth and the development of society. Artisanal and small-scale mining (ASM) is one of these activities. Unfortunately, there is no clear consensus to define ASM. However, its importance is relevant in that it represents, in some cases, the only employment alternative for millions of people, although it also significantly impacts the environment. This work aims to investigate the scientific information related to ASM through a bibliometric analysis and, in addition, to define the new lines that are tending to this field. The study comprises three phases of work: (i) data collection, (ii) data processing and software selection, and (iii) data interpretation. The results reflect that the study on ASM developed intensively from 2010 to the present. In general terms, the research addressed focuses on four interrelated lines: (i) social conditioning factors of ASM, (ii) environmental impacts generated by ASM, (iii) mercury contamination and its implication on health and the environment, and (iv) ASM as a livelihood. The work also defines that geotourism in artisanal mining areas is a significant trend of the last decade, explicitly focusing on the conservation and use of the geological and mining heritage and, in addition, the promotion of sustainable development of ASM.
Dietary Supplements Questioned in the Polish Notification Procedure upon the Basis of Data from the National Register of Functional Foods and the European System of the RASFF
Authors: Wróbel Kacper , Milewska Anna Justyna , Marczak Michał , Kozłowski Remigiusz
Published: July 2022

Dietary supplements (DS) in the countries of the European Union falls within the scope of the food law. DS may, however, contain substances that are simultaneously applied in medicinal products as defined in the pharmaceutical law. The presence of such ingredients may cause problems with the product qualification. The phenomenon of applying such borderline ingredients in dietary supplements may require additional regulations, and ensuring them may be problematic. We conducted an analysis aiming to identify dishonest market practices resorted to by the producers and distributors of non-conforming dietary supplements. We examined mostly questioned DS and compared them with data from the RASFF system and registers of medicinal substances and pharmaceutical entities. The results show that some operators tend to re-notify the same products in response to the initiation of official control procedures. Products in the form of capsules or powders were the most common re-notifications within the 50–100 days. Based on the data obtained, it can be concluded that some entities are obliged to document the safety of the product or its compliance with the regulations, use the imperfection of the notification procedure, and re-notify the questioned product in order to keep it on the market despite potential non-compliance.
Mental Health Literacy and Positive Mental Health in Adolescents: A Correlational Study
Authors: Nobre Joana , Calha António , Luis Henrique , Oliveira Ana Paula , Monteiro Francisco , Ferré-Grau Carme , Sequeira Carlos
Published: July 2022

This study aimed to assess adolescents′ Mental Health Literacy (MHL) level, Positive Mental Health (PMH) level, the association between sociodemographic variables and the MHL and PMH levels, and the relationship between adolescent′s MHL and PMH levels. A quantitative, cross-sectional, correlational study was conducted with a convenience sample of 260 adolescents studying in the 5th to 12th years of school. The Mental Health Knowledge Questionnaire, the Mental Health-Promoting Knowledge, and the Positive Mental Health Questionnaire were used for data collection. Most of the adolescents were female (55.8%) with a mean age of 14.07 years. The participants showed good levels of MHL (MHKQ). The participants showed good levels of MHL (MHKQ 𝘹¯ = 60.03; MHPK-10 𝘹¯ = 4.49) and high levels of PMH (𝘹¯ = 128.25). The adolescents with higher levels of MHL were the oldest, in a higher year of school, female, those whose mothers are employed, those who have healthy eating habits, and those who have a better body image self-perception. Adolescents in a lower year of school, with adequate sleep habits, who spend fewer hours a day in front of a screen or online, and who have a better self-perception of mental and physical health and body image were the ones with higher PMH levels. These findings suggest the need to implement experimental or quasi-experimental studies to ascertain the effectiveness of interventions that promote adolescents′ positive mental health literacy.
Internet Addiction and Polish Women’s Sexual Functioning: The Role of Social Media, Online Pornography, and Game Use during the COVID-19 Pandemic—Online Surveys Based on FSFI and BSMAS Questionnaires
Authors: Pawlikowska Anna , Szuster Ewa , Kostrzewska Paulina , Mandera Amanda , Biernikiewicz Małgorzata , Sobieszczańska Małgorzata , Rożek-Piechura Krystyna , Markiewicz Monika , Rusiecka Agnieszka , Kałka Dariusz
Published: July 2022

In this study, we investigated the relationship between social media use and women’s sexual functioning during the COVID-19 pandemic. Data were collected between April and November 2021. Online surveys including the Female Sexual Functioning Index (FSFI) and Bergen Social Media Addiction Scale (BSMAS) questionnaires were distributed to young, sexually active women. Information was collected on their demographics, sexual life, and use of social media. We enrolled 546 women (mean age 23.07 ± 4.69). In general, 5.68% of the women were at high risk of social media addiction. Social media addiction had a negative impact on FSFI scores, while pornography use had a positive effect on women’s sexual functioning. Users of dating apps also obtained lower FSFI scores than non-users. No differences in FSFI scores were observed between gamers and non-gamers. The impact of time spent on social media on FSFI scores was not significant. We conclude that social media addiction negatively affected women’s sexual functioning during the COVID-19 pandemic.
Clinical Characteristics and Potential Risk Factors Associated with the SARS-CoV-2 Infection: Survey on a Health Care Workers (HCWs) Population in Northern Italy
Authors: Novelli Viola , Fassio Federico , Resani Guido , Bussa Martino , Durbano Alessandro , Meloni Alessandro , Oliva Giovanni , Cutti Sara , Girardi Daniela , Odone Anna , Villani Simona , Marena Carlo , Muzzi Alba , Monti Maria Cristina
Published: July 2022

During the two years of the COVID-19 pandemic, more than 400 million cases all over the world have been identified. Health care workers were among the first to deal with this virus and consequently a high incidence of infection was reported in this population. The aim of the survey was to investigate health care workers’ (HCWs) clinical characteristics and potential risk factors associated with the SARS-CoV-2 infection in a referral hospital in Northern Italy after the first and second waves of the pandemic. We administered a questionnaire during the flu vaccination campaign that took place at the end of 2020; among 1386 vaccinated HCWs, data was collected and analyzed for 1065 subjects. 182 HCWs (17%) declared that they had tested positive on at least a molecular or a serological test since the beginning of the pandemic. Comparing the infected vs. not infected HCWs, median age, BMI, smoking habit, presence of hypertension or other comorbidities were not significantly different, while having worked in a COVID ward was associated with the infection (ORadj = 1.54, 95% CI: 1.07–2.20). Respondents declared that more than 70% of contacts occurred in the hospital with patients or colleagues, while about 15% in domestic environments. Among the infected, the most reported symptoms were fever (62.1%), asthenia (60.3%), anosmia/ageusia (53.5%), arthralgia/myalgia (48.3%), headache or other neurological symptoms (46.6%), cough (43.1%) and flu-like syndrome (41.4%). The percentage of subjects who have been infected with SARS-CoV-2 seems to be higher in HCWs than in the general population; hence, in hospitals, protective measures and preventive strategies to avoid the spreading of the contagion remain crucial.
Does Managerial Ability Lead to Different Cost Stickiness Behavior? Evidence from ASEAN Countries
Authors: Restuti Mitha Dwi , Gani Lindawati , Shauki Elvia R. , Leo Lianny
Published: July 2022

This study aims to test cost stickiness behavior under different managerial ability levels. Managerial ability plays an important role in resource-related decision making. Previous cost stickiness research assumes that managers exhibit similar abilities to manage resources. However, managers with different managerial abilities may make different resource decisions, which leads to different cost stickiness levels. More able managers can manage resources efficiently and deal with resource shortages. This study also tests the effects of environmental uncertainty on cost stickiness under different managerial ability levels. Managers’ resource decisions must consider environmental uncertainty to generate optimal returns. More able managers are more willing to take risks and manage resources efficiently to deal with uncertainty. Meanwhile, less able managers tend to retain resources to cope with environmental uncertainty. We ran the panel regression analysis of 19,612 listed firm-year observations in ASEAN countries from 2013 to 2019. The results show that firms led by less able managers exhibit cost stickiness. Less able managers cannot manage resources efficiently and are more likely to retain resources than make costly adjustments. Further, the effect of environmental uncertainty on cost stickiness is stronger in firms led by less able managers. Less able managers tend to retain resources when sales decline.
Towards Financing System of Integrated Enterprise Development in the Time of COVID-19 Outbreak
Authors: Boichenko Kateryna , Gherghina Ștefan Cristian , Abreu António , Mata Mário Nuno , Martins José Moleiro
Published: July 2022

The development of an enterprise under current conditions requires an integrated approach and an appropriate financing system. The purpose of this study is to justify the replication model of financing the integrated enterprise development. The research methodology suggests that each enterprise has its own development “genome”, which makes it possible to apply the replication of its directions based on a justified financing system of such an integration. The proposed replication model is augmented by regression analysis, which made it possible to carry out scenario forecasting of alternative options for the company’s development. The conduction of the study is based on 16 textile enterprises. The formed map of the integrated enterprise development enabled the determination of their points to replicate resources in four directions (environmental and economic, innovative, informational, and organizational). The interaction of companies on the basis of strengths diffusion (exchange of potential) with the application of financial netting is considered an alternative to replication. The research proved that an alternative option can solely be recommended for developed companies and requires the identification and minimization of risks. The strong link between the level of integrated and overall development of companies was acknowledged. Asymmetry of business development in the context of a replication model of its integration enables the achievement of high results while minimizing financial resources. Enterprises implementing the replication model of integration considerably improve their prospects and increase overall development performance. The application of the replication model of financing integration under the crisis and the COVID-19 pandemic fosters efficient use of financial resources and the overall enterprise development.