bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience of operation of the UDP-2001SM railway wheelset bearing vibration diagnostics installation and the OMSD-02 mechanism diagnostics system
Authors: Otoka A. G. , Budnik D. V. , Liakh A. M.
Published: November 2022

The Aim of the paper is to compare the UDP-2001SM installation for vibration diagnostics of bearings of freight, refrigerator and passenger car wheels and the OMSD-02 mechanism diagnostics system that since recently has been used in the Belarusian Railway.Methods. By way of analysis of the UDP-2001SM vibration diagnostics installation and the OMSD-02 mechanism diagnostics system, the authors considered the list of identifiable defects, method for defining threshold values (reference levels) of vibroacoustic pulses and noises for the criteria of “faulty” and “good”, statistical data for rejected axleboxes of freight and passenger car wheelsets in respect to the overall number of conducted measurements, the experience of operation in various car shops of the Belarusian Railway. Results. The paper describes the process of vibration diagnostics of wheelset bearings of freight and passenger cars using the case of stationary acquisition of vibroacoustic signals from acoustic plates that interact with the diagnosed axlebox. The authors present the diagrams of the UDP-2001SM installation and OMSD-02 system, as well as the defects of bearings that are to be identified using the above diagnostics equipment. Conclusion. The paper showed the advantages and disadvantages of the above diagnostics systems based on the experience of their application in a number of car shops of the Belarusian Railway.
Rodzice w procesie rozwijania umiejętności językowych i czytelniczych młodszych dzieci ze specjalnymi potrzebami rozwojowymi – stan badań i perspektywy badawcze
Authors: Kuracki Kamil
Published: November 2022

W artykule dokonano przeglądu badań empirycznych dotyczących czynników determinujących rodzicielskie strategie rozwijania umiejętności językowych i kształtowania gotowości do czytania i pisania dzieci ze specjalnymi potrzebami rozwojowymi w okresie wczesnego i średniego dzieciństwa. Szczególną uwagę zwrócono na zróżnicowane praktyki rodziców w zakresie organizowania i przebiegu wczesnych inicjacji czytelniczych, podejmowanych w środowisku domowym. Przeprowadzona analiza prac empirycznych pozwoliła na wskazanie obszarów dociekań naukowych w prowadzonych współcześnie projektach badawczych oraz na zarysowanie możliwych kierunków przyszłych badań z zakresu omawianej problematyki.
Zajęcia rewalidacyjne w kontekście usprawniania koordynacji wzrokowo- -ruchowej uczniów z niepełnosprawnością intelektualną – z pamięcią o Marii Grzegorzewskiej
Authors: Krawiecka Kinga
Published: November 2022

Artykuł poświęcony jest rewalidacji w zakresie usprawniania koordynacji wzrokowo-ruchowej dzieci z niepełnosprawnością intelektualną w stopniu umiarkowanym – uczniów klas I-III szkoły podstawowej specjalnej. W kontekście teoretycznym zaprezentowano ograniczania w obszarze koordynacji wzrokowo-ruchowej uczniów z niepełnosprawnością intelektualną. Ponadto, podjęto się rozważań nad sensem rewalidacji, który wyłania się z kanonu działań pedagogicznych Marii Grzegorzewskiej. W kontekście praktycznym przedstawiono autorski pomysł na prowadzenie zajęć rewalidacyjnych, inspirowany treścią bajki terapeutycznej Małgorzaty Różyńskiej oraz Programem Rozwijającym Percepcję Wzrokową autorstwa Marianne Frostig i Davida Horne’a.
Umiędzynarodowienie uczelni wyższych w Polsce z uwzględnieniem kierunków pedagogicznych
Authors: Korczak Jarosław
Published: November 2022

Celem artykułu jest ukazanie specyfiki obecności studentów zagranicznych studiujących na uczelniach wyższych z uwzględnieniem kierunków pedagogicznych. Na początku artykułu omówiono zagadnienia jakimi są: internacjonalizacja uczelni wyższych, jej wyzwania oraz związane z nią możliwości. Następnie przedstawiono dane ilościowe obrazujące specyfikę obecności studentów zagranicznych na uczelniach wyższych, zarówno w kontekście światowym jak i polskim (w tym związane z obecnością zagranicznych studentów na kierunkach pedagogicznych). Na końcu zaś zawarto uwagi oraz po postulaty związane z potrzebami oraz działaniami, które mogą przyczynić się do zwiększenia stopnia internacjonalizacji uczelni wyższych w Polsce, w kontekście ogólnym oraz w odniesieniu do kierunków pedagogicznych. Omówione niżej zagadnienia związane z internacjonalizacją oraz jej stanem w Polsce, z uwzględnieniem kwestii odnoszących się do kierunków pedagogicznych, w założeniu autora, powinny pełnić rolę przyczynku do podjęcia kolejnych inicjatyw w kierunku wielowymiarowej popularyzacji tego zjawiska – zarówno w rozważaniach teoretycznych jak i działaniach praktycznych.
Seniors during the COVID-19 pandemic
Authors: Seredyńska Anna
Published: November 2022

The time of the pandemic was a time of crisis for the whole world. Young people lost their jobs, they were prevented from implementing their plans, and their social contacts were drastically limited. The article, however, focuses on seniors, for whom it was a period during which they feared for their lives. Many of them died, many lost their health, and many lost their loved ones. The study described in the article was conducted using the interview technique and analysed the situation of seniors during the pandemic. The analysis was based on several main problems occurring during the pandemic, which were chosen on the basis of the findings reported in the subject literature, namely: treatment, shopping opportunities, loneliness, social isolation, inactivity, information chaos exacerbated by seniors’ reduced ability to access electronic sources, fear of illness and fear of death. The interviews were conducted with 12 seniors and one nursing assistant who worked in a nursing home. They revealed that the main and most painful problems the respondents faced during the pandemic were: loneliness, inactivity, lack of access to religious practices in places of worship, as well as symptoms of depression, anxiety and post-traumatic stress disorders they experienced in response to the situation.
Bioactives from Marine Organisms and their Potential Role as Matrix Metalloproteinase Inhibitors
Authors: Qian Zhong Ji , Thomas Noel Vinay , Monica Diyya Apoorva Salomy , Kim Se-Kwon , Faraj Kaeuis Aziz , Ghafoor Dlzar Dlshad , Tigabu Bereket Molla
Published: November 2022

Recent research has revealed the role of metalloproteinases in a number of severe pathological illnesses, including cardiac, cartilage, neurological, and cancer-related diseases that are fatal to humans. Metalloproteinases are a subclass of endopeptidases that comprise structurally identical enzymes known as Matrix Metalloproteinases [MMPs] that are solely involved in extracellular matrix degradation and play a significant regulatory function in tissue remodeling.
Improper regulation and expression of MMPs have been linked to several life-threatening pathological conditions in humans. Hence there is an ever-growing interest in various research communities to identify and report the Matrix Metalloproteinase Inhibitors [MMPIs]. In spite of several chemically synthesized MMPIs being available currently, several unpleasant side effects, un-successful clinical trials have made use of synthetic MMPIs as a risky strategy. Several natural product researchers have strongly recommended and reported many natural resources like plants, microorganisms, and animals as greater resources to screen for bioactives that can function as potential natural MMPIs. Marine environment is one of the vast and promising resources that harbor diverse forms of life known to synthesize biologically active compounds. These bioactive compounds from marine organisms have been reported for their unparalleled biological effects and have profound applications in cosmeceutical, nutraceutical, and pharmaceutical research. Several research groups have reported an umpteen number of medicinally unmatched compounds from marine flora and fauna, thus driving researchers to screen marine organisms for natural MMPIs. In this review, our group has reported the potential MMPIs from marine organisms.
Computational Investigation of Ligand Binding of Flavonoids in Cytochrome
P450 Receptors
Authors: Wilson Philippe B. , Odoemelam Chiemela S. , Hunter Elena , Ahmad Zeeshan , Kamerlin Caroline Lynn , White Samuel
Published: November 2022

Aim:

The cytochrome P450 enzymes play a significant role in regulating cellular and physiological processes by activating endogenous compounds. They also play an essential role in the detoxification process of xenobiotics. Flavonoids belong to a class of polyphenols found in food, such as vegetables, red wine, beer, and fruits, which modulate biological functions in the body.

Method:

The inhibition of CYP1A1 and CYP1B1 using nutritional sources has been reported as a strategy for cancer prevention. This study investigated the interactions of selected flavonoids binding to the cytochrome P450 enzymes (CYP1A1 and CYP1B1) and their ADMET properties in silico. From docking studies, our findings showed flavonoids, isorhamnetin and pedalitin, to have the strongest binding energies in the crystal structures 6DWM and 6IQ5.

Results/Discussion:

The amino acid residues Asp 313 and Phe 224 in 6DWM interacted with all the ligands investigated, and Ala 330 in 6IQ5 interacted with all the ligands examined. The ligands did not violate any drug-likeness parameters.

Conclusion:

These data suggest roles for isorhamnetin and pedalitin as potential precursors for natural product-derived therapies.
Novel Insights into the Important Role of Leptin in Modulating the
Pathological Development of Fibrotic-related Diseases
Authors: Kang Huiyuan , Lai Min , Yao Yan’er , Wang Bin , Su Xin , Cheng Ye
Published: November 2022

Abstracts:

Leptin, as one of the most important cytokines within the circulation, has
been confirmed to play a vital role in the hypothalamus of the central nervous system
(CNS), which could modulate energy homeostasis by suppressing food intake. Furthermore,
leptin could also influence cell metabolism by acting directly on the leptin
receptor, which is a relatively small peptide and is mainly produced and released by fat
tissue in mammals. On the other hand, the excessive extracellular matrix (ECM) could
induce damage in normal tissues or organ structures, which might further induce fibrotic
development in multiple tissues or organs, including the liver, heart, and kidneys.
Notably, the sustainable development of fibrosis promotes the structural lesion and
functional decline of different organs, which subsequently threatens human health and
poses serious risks to human life. Emerging evidence has shown that leptin plays an
important role in the fibrotic progression within multiple tissues and organs in mammals
and has an alleviating effect on fibrosis. Concerning this notion, it has been proposed
that leptin could be identified as a vital therapeutic strategy for fibrotic progression
in clinical practice. Consequently, this review summarized the potential mechanisms
of leptin in modulating fibrotic development in diverse tissues and organs to
provide a theoretical basis for treating fibrotic-related diseases. In addition, the potential
mechanisms whereby leptin affects the development of fibrosis were also summarized
in the current review.
Evaluation of Oral Dryness and the Salivary-flow Rate in Patients with Oral Lichen Planus
Authors: Assapattarapun Varisa , Talungchit Sineepat , Jirawechwongsakul Pimporn , Taebunpakul Patrayu
Published: November 2022

Background and Objectives:

Oral lichen planus (OLP) is a common T-cell-mediated inflammatory oral mucosal disease. One of the complaints among OLP patients is xerostomia. However, the relationship between oral dryness and a decreased salivary-flow rate in these patients is not yet conclusive. So, we investigated oral dryness and the salivary-flow rate in OLP patients using various measurements.

Material and Methods:

Thirty OLP patients and 30 controls were included. The oral-dryness symptoms were collected using the Xerostomia Inventory (XI) and Bother Index (BI). The salivary-flow rate was measured using a Modified Schirmer Test (MST) and the spitting method. The clinical signs of dry mouth were determined by the clinical oral-dryness score (CODS). The Thongprasom score was used to evaluate the severity of OLP. The data were analyzed using the Mann-Whitney U test and Spearman’s rank correlation coefficient.

Results:

The XI score and BI score in the OLP group were significantly higher than in the control group. However, CODS, MST, the unstimulated salivary-flow rate, and the stimulated salivary-flow rate were not significantly different between the two groups. There was no correlation between oral dryness and the salivary-flow rate in OLP patients. The severity of OLP was also not correlated to oral dryness and the salivary-flow rate.

Conclusion:

OLP patients had more complaints about mouth dryness than the controls. However, the salivary-flow rates between the two groups were not different. Additionally, the severity of OLP was not related to dry mouth or the salivary-flow rate. The possible reasons for oral dryness among people with OLP require further investigation.
Evaluating the Cost-Effectiveness of Plastic Surgery Based on the Satisfaction with Quality of Life and Nasolabial Appearance in Thai Preteens with Cleft Lip and Palate
Authors: Surakunprapha Palakorn , Pradubwong Suteera , Jenwitheesuk Kamonwan , Pisek Poonsak , Chowchuen Bowornsilp
Published: November 2022

Background:

Cleft Lip and Palate (CLP) negatively affect the quality of life (QoL) and nasolabial appearance, especially in preteen patients who start to be interested in their own appearance and society.

Objective:

The objective of this study is to evaluate the cost-effectiveness of plastic surgery for Thai preteen CLP patients through their satisfaction with their QoL and nasolabial appearance.

Methods:

A cross-sectional study covered purposively selected 30 samples aged between 8 and 12 years old.Their satisfaction with their QoL and appearance was reflected through an interview and a questionnaire with the cooperation of their parents as their caregivers including satisfaction with their nasolabial appearance evaluated by five experts. They compared the photos of patients’nasolabial appearance with those of normal faces of children of the same age using 5-rating scales.

Results:

General findings showed 53.3% of samples were male patients with mostly (63.3%) UCLP whose parents were mainly (73.3%) poor, so they relied on government financial supports for the treatment. Only some (15%) earned up to 5,001 to 10,000 baht per month because of their low education with just high school level. Specific findings indicated the overall satisfaction with QoL through five dimensions at average level (3.26±1.39). This was based on the satisfaction with the center services, the overall treatments, the medical additional costs, parental satisfaction with psychosocial effects including concerns about the impacts of CLP on the family ranged from high to low i.e. 4.30±0.98, 3.72±1.15, 3.70±1.14, 3.33±1.08 and 2.81±1.46 respectively. Moreover, five experts trended to be highly satisfied with patients’ nasolabial appearance by rating it from Good (53.3%) to Fair (43.43%) with only Poor (3.3%).

Conclusion:

The good cost-effectiveness of the surgery was represented through the average and high satisfaction of CLP patients with their QoL and their appearance respectively indicating the absence of disability weights for these treated CLP patients.
FASN Inhibitors Enhance Bestatin-Related Tumor Cell Apoptosis
Through Upregulating PEPT1
Authors: Chen Shu-zhen , Ni Jun , Shang Yue , Wang Wen-die , Wang Chen , Wang Ai-min , Li Gao-jie
Published: November 2022

Background:

Fatty acid synthase (FASN) is generally over-expressed in human tumor
tissues and catalyzes de novo synthesis of fatty acids on which tumor cells depend. Bestatin, an
inhibitor of aminopeptidase/CD13, is one of the dipeptide substrates for the human oligopeptide
transporter 1 (PEPT1).

Objectives:

In the current study, we aimed to uncover the role of FASN inhibitors in bestatin-induced tumor cell apoptosis and the underlying mechanism, extending our understanding of the correlations between FASN and PEPT1 in cancer and providing a new strategy for tumor targeted treatment.

Methods:

Cerulenin, orlistat and siRNAs were applied to inhibit FASN. The cell viability and
apoptosis were assessed with MTT (thiazolyl blue tetrazolium bromide) assays and annexin VFITC/
PI staining with flow cytometry analysis. Western blot and qRT-PCR analysis were used to
detect the protein levels and mRNA levels of the indicated genes in tumor cells, respectively.
Protein degradation or stability was examined with cycloheximide chase assays. CD13 activity
was detected by gelatin zymography. The HT1080 and C26 xenografts models were conducted
to assess the efficacy in vivo.

Results:

In the current study, we found that inhibiting FASN by cerulenin and orlistat both augmented
the effects of bestatin in decreasing tumor cell viability. Cerulenin increased the apoptosis
rates and enhanced the cleavage of PARP caused by bestatin. Furthermore, cerulenin, orlistat
and siFASNs markedly elevated PEPT1 protein levels. Indeed, cerulenin induced the upregulation
of PEPT1 mRNA expression rather than affecting the protein level after the cells were
treated with CHX. And Gly-Sar, a typical competitive substrate of PEPT1, could attenuate the
augment of bestatin-induced cell killing by cerulenin. Moreover, synergistic restrain of tumor
growth accompanied by a reduction of Ki-67 and increment of TUNEL was significantly
achieved in the xenograft models. Interestingly, no clear correlation was observed between the
CD13 with FASN and/or PEPT1 in tumor cells.

Conclusion:

FASN inhibitors facilitate tumor cells susceptible to bestatin-induced apoptosis involving
the up-regulation of PEPT1 at the mRNA translation level and the transport of bestatin
by PEPT1, emerging as a promising strategy for tumor targeted therapy.
Modeling Inflammatory Bowel Disease by Intestinal Organoids
Authors: Di Giorgio Cristina , Roselli Rosalinda , Biagioli Michele , Bordoni Martina , Ricci Patrizia , Zampella Angela , Distrutti Eleonora , Donini Annibale , Fiorucci Stefano
Published: November 2022

Inflammatory bowel disease (IBD) is a chronic and relapsing disease caused by a
dysregulated immune response to host intestinal microbiota that occurs in genetically predisposed
individuals. IBD encompasses two major clinical entities: ulcerative colitis (UC), limited to the
colonic mucosa, and Crohn's disease (CD), which might affect any segment of the gastrointestinal
tract. Despite the prevalence of IBD increasing worldwide, therapy remains suboptimal, largely
because of the variability of causative mechanisms, raising the need to develop individualized
therapeutic approaches targeted to each individual patient. In this context, patients-derived intestinal
organoids represent an effective tool for advancing our understanding of IBD’s pathogenesis.
Organoid 3D culture systems offer a unique model for dissecting epithelial mechanisms involved
IBDs and testing individualized therapy, although the lack of a functional immune system and a
microbiota, two driving components of the IBD pathogenesis, represent a major barrier to their
exploitation in clinical medicine. In this review, we have examined how to improve the translational
utility of intestinal organoids in IBD and how co-cultures of 3D or 2D organoids and immune
cells and/or intestinal microbiota might help to overcome these limitations.
A Review of Preclinical Tools to Validate Anti-Diarrheal Agents
Authors: Sarma Rajdeep , Shakya Anshul , Karmakar Arka , Ghosh Surajit Kumar , Bhat Hans Raj , Ghimire Neha , Rahman Obaidur
Published: November 2022

Background:

Since their inception, preclinical experimental models have played an important role in investigating and characterizing disease pathogenesis. These in vivo, ex vivo, and in vitro preclinical tests also aid in identifying targets, evaluating potential therapeutic drugs, and validating treatment protocols.

Introduction:

Diarrhea is a leading cause of mortality and morbidity, particularly among children in developing countries, and it represents a huge health-care challenge on a global scale. Due to its chronic manifestations, alternative anti-diarrheal medications must be tested and developed because of the undesirable side effects of currently existing anti-diarrheal drugs.

Methods:

Several online databases, including Science Direct, PubMed, Web of Science, Google Scholar and Scopus, were used in the literature search. The datasets were searched for entries of studies up to May, 2022.

Results:

The exhaustive literature study provides a large number of in vivo, in vitro and ex vivo models, which have been used for evaluating the mechanism of the anti-diarrheal effect of drugs in chemically-, pathogen-, disease-induced animal models of diarrhea. The advances and challenges of each model were also addressed in this review.

Conclusion:

This review encompasses diverse strategies for screening drugs with anti-diarrheal effects and covers a wide range of pathophysiological and molecular mechanisms linked to diarrhea, with a particular emphasis on the challenges of evaluating and predictively validating these experimental models in preclinical studies. This could also help researchers find a new medicine to treat diabetes more effectively and with fewer adverse effects.
For the Record: Exploring variability in interpretations of police investigative interviews
Authors: Deamer Felicity , Richardson Emma , Basu Nabanita , Haworth Kate
Published: November 2022

Recent research (Haworth 2018) has demonstrated how investigativeinterview data are (unintentionally) distorted as they pass through the criminaljustice system, and the survey-based experiment we present here was designedto test our hypothesis that various aspects of the processing of police-suspectinterview data may have an impact on the quality of the official evidentialdocument produced. The quantitative and qualitative findings from thisexperiment shed light on, and provide a sound evidence base for this claim, ratherthan leaving it as an untested assumption. The experiment was designed totest each key aspect of the current process of the production of routine writtentranscripts of investigative interviews (ROTIs), focusing on the conversion fromspoken to written format, and the use of different transcription conventions, andit has enabled us to investigate which changes make the most difference in termsof the evidential quality of the end product, in order to effect a change in practicewhich will reduce or eliminate the effect of those changes. Our findings suggestthat when presented with a transcript of a police interview, we are significantlymore likely to (1) perceive the interviewee as anxious and unrelaxed, (2) interpretthe interviewee’s behaviour as being agitated, aggressive, defensive, and nervous,(3) determine that the interviewee is un-calm and uncooperative, and (4) deemthe interviewee’s version of events to be untrue, than we are if we listen to theoriginal audio recording. Moreover, subjects identified (a) consistency, (b) phraseand lexical choice, (c) emotion (crying/upset), (d) hesitation and/or pauses assignificant factors influencing participants’ perception and interpretation of theinterviewee and their story. This is particularly concerning as the latter twofeatures are not currently routinely included in police transcripts, and Haworth(2018) illustrates multiple ways in which transcripts might differ from the originalaudio recordings they are intended to replace, with respect to words and phrases,as well as general content. The findings presented in this paper provide a strongmotivation for further research into how we capture spoken interaction in legalcontexts, and they constitute something of a mandate for reform with respect tothe transcription of police interviews in the UK.
Contradiction between natural-legal and positive-legal theories: theoretical and practical aspects
Authors:   Leonid V. Karnaushenko KrasnodarUniversity of the Russian MIA, Karnaushenko Leonid V.
Published: November 2022

The contradiction between the theory of natural law and the theory of positive law has a long history. In most studies on the relationship between natural-legal and positive-legal theories, their incompatibility is not called into question. However, in practice, both theories influence the legal sphere, which actualizes the significance of the formation of scientific theory, which reveals the question of combining elements of natural-legal and positive-legal theories. Within the framework of this work, an approach has been taken to consider the difference between the theoretical and practical aspects of the relationship between theories of natural law and positive law. During the study, methods of analysis, synthesis, comparison, abstraction and generalization are used, as well as theoretical achievements of representatives of the historical school of philosophy of science are used. As a result of the study, it was found that the original contradiction between the theories of natural and positive law de-termined their allocation in two areas of legal research, which differ in subject and methodological terms. This discrepancy defined the transition from contradiction between the two theories to their coverage of different aspects of law, which made possible the mutual addition of elements of natural and positive legal theories in the practical sphere.
Foreign legislation on the institution of replacing the wrong party in administrative proceedings
Authors:   Olga A. Derbisheva State Educational Organization of Higher Professional Education ", Derbisheva Olga A. ,   Donetsk Academy of Internal Affairs of the Ministry of Internal Affairs of the DPR"
Published: November 2022

The article provides a comprehensive analysis of foreign legislation on the institution of replacing the wrong party in administrative proceedings. The legislation of the Romano-Germanic and Anglo-Saxon legal families was taken as a basis. As a result, it was concluded that it is necessary to form an institution for replacing the wrong party in domestic legislation. The purpose of this study should be considered a systematic analysis of foreign regulations governing the replacement of the wrong party in administrative proceedings. Thus, this approach within the framework of comparative law is focused on identifying the features of this institution in foreign countries. Of particular interest is the division of foreign legislation into the Romano-Germanic legal family and the Anglo-Saxon, respectively. In addition, a detailed study followed by a comprehensive analysis of the legal systems of foreign countries is widely used by modern scientists in this field, as well as law-making bodies of many legal states. The complex application of the comparative method is focused on improving the regulations, in particular with regard to the institution of replacing the wrong party. The foreign legal and technical methods revealed as a result of the study can become the foundation for the regulation of modern social relations by the rule of law. Methodological basis: when writing this article, general and special methods of scientific knowledge were used. In particular, the dialectical method as the main way of objective and comprehensive knowledge of reality, as well as the formal logical method, including the methods of analysis and synthesis, deduction and induction, systemic, comparative legal, historical legal and formal legal approaches. Research results: the article is supposed to conduct a comprehensive and comprehensive analysis of foreign legislation on the institution of replacing the wrong party in administrative proceedings, within which the legislation of the Romano-Germanic and Anglo-Saxon legal families was taken as a basis.
Factors analysis of lean six sigma practices in the Vietnam wood industry
Authors:   Faculty of Industrial and Energy Management, Electric Power University, Hanoi, Vietnam, Minh Nguyen Dat
Published: November 2022

Six sigma is valuable to process control and ensure the stability of product quality. Lean practices or six sigma in isolation cannot remove all types of waste, control the process statistically, and remove process variability. The integrated development of the two approaches, which are known as Lean and six sigma (LSS), may bring out the advantages of both concepts. Although, many enterprises have succeeded with LSS around the world only less than 20% of enterprises achieve and maintain lean activities for the time being. The aim of this research paper is to present the key factors that constitute a successful implementation of LSS in the wood industry in Vietnam through analysis of LSS implementation. A combination of a comprehensive literature review and a site visit to deeply observe by participants observation for 3 LSS projects and interview the key persons involved in the project was employed in this study.
Asociación in vitro de Duddingtonia flagrans con ivermectina en el control de nematodos gastrointestinales de búfalos
Authors: Mendes Luanderson Queiroz , Ferraz Carolina Magri , Perim Carolina Motta , Araújo Jackson Victor , Ferrari Emanueli Simonassi , Rodrigues Jossiara Abrante , Luz Julia Roza , Souza Rafael de Oliveira , Vilela Vinicius Longo Ribeiro , Moreira Tiago Facury , Fidelis Junior Otavio Luiz , Hiura Emy , Braga Fabio Ribeiro
Published: November 2022

Objective. The objective of this study was to evaluate the in vitro association of the fungus Duddingtonia flagrans (AC001) and ivermectin in the control of gastrointestinal nematodes of buffalo calves. Materials and Methods. Four experimental groups were formed in microtubes, with five replicates for each group: G1 (nematodes + AC001), G2 (nematodes + ivermectin 1%), G3 (nematodes + AC001 + ivermectin 1%) and G4 (nematodes + distilled water). For each group, after 36 hours of interaction, the content of the microtubes was read by optical microscopy, accounting for the number of nematodes per group. Results. There was a significant larval reduction of the treated groups, with the following percentages in relation to G4 (control): G1: 43.7%; G2: 82.3% and G3: 65.7%. It was also observed that the in vitro association of D. flagrans with ivermectin was more effective in reducing L3 when compared to the isolated use of this fungus. Conclusions. It was concluded that the joint use of D. flagrans with ivermectin can potentiate the efficacy of biological control of gastrointestinal nematodes of buffalo calves, envisioning its use under natural conditions of buffalo breeding.
Perfil fermentativo, calidad nutricional y estabilidad aerobia de ensilajes mezclados de hierba elefante (Pennisetum purpureum Schum) y maní forrajero (Arachis pintoi)
Authors: Araújo Cleyton de Almeida , Novaes Judicael Janderson da Silva , De Araújo Janiele Santos , De Macedo Amélia , Silva Crislane de Souza , Da Silva Tamiris da Cruz , Emerenciano Neto João Virgínio , Leal de Araújo Gherman Garcia , Campos Fleming Sena , Gois Glayciane Costa
Published: November 2022

Objective. Determine the fermentative profile, proximate composition, and aerobic stability of mixed silages of elephant grass combined with levels of forage peanut. Materials and methods. Different levels of forage peanut (0.0, 20.0, 40.0, 60.0, and 80.0% on FM basis) were added to elephant grass silages. A completely randomized design was adopted, with 5 treatments and 3 repetitions, totaling 15 experimental silos that were opened after 30 days of sealing. Fermentative profile, proximate composition, and aerobic stability were evaluated. Results. The increase in the forage peanut levels in the elephant grass silages promoted a increasing on porosity, permeability, density, and pH (p<0.001). A 0.58 reduction in Flieg index for every 1% forage peanut added to the elephant grass silage was observed (p<0.001). The sum of the silage temperature difference compared to the environment (p=0.032) and aerobic stability (p<0.001) showed a quadratic effect. The forage peanut inclusion in elephant grass silages reduced the dry matter, organic matter, neutral and acid detergent fiber, hemicellulose, cellulose, and total carbohydrates (p<0.05) and increased the mineral matter, crude protein, lignin, non-fibrous carbohydrates, and total digestible nutrients (p<0.05). Conclusions. Under the experimental conditions, recommend the inclusion of up to 40% forage peanut combined with elephant grass to compose mixed silages, due to the better fermentative dynamic, nutritional profile, and aerobic stability.
Istilah Baru Era Pandemi COVID-19 di Bahasa Indonesia dan Bahasa Korea: Kajian Neologisme Pendekatan Linguistik Korpus
Authors: Wahyuningsih Sri
Published: November 2022

This study tries to identify the use of new word (neologisms) during the COVID-19 pandemic era in Indonesian and Korean online newspapers with a corpus linguistic approach. The corpus data collected from online newspaper articles with the theme of COVID-19, both in Korean and Indonesian online newspapers. A total of 2,515,019 words scale of corpus data were used in the study collected from September 1, 2020 to March 31, 2021. Based on the analysis, it was found that in both Indonesian and Korean, neologisms related to the COVID-19 pandemic can be categorized into 4 categories, namely 1) health registers, 2) government policy registers, 3) people's habits, and 4) other categories. The health register occupies the first position with the highest frequency of neologisms both in the Indonesian language, by placing words that refer to COVID-19, namely Covid-19 (Indonesian) and 코로나 19 (khorona ilgu / Korean language) as the most used neologisms. Meanwhile, there are differences in the use of neologisms in the categories of government policies, people's habits, and others. The differences are correlated with the differences in government policies in handling the COVID-19 pandemic and the conditions of the society of both countries.
Honorifik Bahasa Korea dan Bahasa Indonesia
Authors: Hanani Iva
Published: November 2022

The aim of this study is to describe the Korean and Indonesian honorifics and compare the honorifics of the two languages. This research is a qualitative research using a contrastive analysis method. Data in the Korean language is collected from the author's private messages with Korean, and data in Indonesian is collected from examples in the referenced literature and substituted with words from the same word class. Based on the analysis that has been carried out, Korean and Indonesian honorifics are both grammatically and lexically realized. However, the grammatical elements that make up Korean honorifics are not limited to one type of sentence, while in Indonesian it is only used in imperative sentences. Vocabularies that contain honorific meanings in Korean are found in adjectives, verbs, and personal pronouns, while in Indonesian mostly are found in personal pronouns and only a few in words from other word classes. From the point of view of Korean honorifics, Indonesian honorifics can be classified into hearer honorifics. In addition, the Indonesian language has subject honorifics, either directly or indirectly, which are lexically realized.
Perspectives on Intercultural Contact and Japanese Learning by Indonesian Trainees in Japan
Authors: Nurjaleka Lisda
Published: November 2022

Intercultural Contact (Hereafter IC) is when two or more people from different cultural backgrounds carry out socio-economic or political exchanges in one contact zone. Intercultural contact is possible to appear everywhere and by one. Intercultural contact concerning immigrants, either as students or workers abroad. This study aims to investigate the intercultural contact of Indonesian workers, focusing on trainees (Jjisshusei) in Japan. International workers face cross-cultural communication with co-workers or domestic workers. The trainees as respondents in this study are sent to Japan as a form of on-the-job training in collaboration between the Indonesian government and the Japanese. The trainees were exposed to the Japanese language, culture, society, and economy. Therefore, their cultural competence is essential. This study examines intercultural communication in the trainee’s community, mainly focusing on how intercultural contact occurs between trainees and Japanese residents. The result showed that apart from the trainees’ understanding of the importance of learning Japanese, they still lack experience in communicating with Japanese locals besides their co-workers. This study contributes to second language learning in intercultural understanding and L2 learners’ identity.
Time series analysis in epidemiological studies using the R language
Authors: Santos Anderson Lineu Siqueira dos , Cravo Layna de Cassia Campos , Cordeiro Fabricio Gonçalves , Carrera Maria de Fátima Pinheiro , El-Husny Claudia Ozela , Yasutake Rubia Rodrigues Neves , Santos Emerson Glauber Abreu dos , Simor Alzinei , Mendonça Evelyn Tayana Maciel , Corrêa Thiago Souza , Oliveira Tatyellen Natasha da Costa
Published: November 2022

Objective: To present a script script to use the RStudio software for decomposition of time series in epidemiological studies using the R language. Materials and methods: The data used in this study to demonstrate the applicability of the R environment in the analysis and decomposition of time series were extracted from DATASUS, and composed of data on mortality from infectious diseases in Brazil and in the North Region, considering deaths by residence, from 1996 to 2019. The data were analyzed using the R language through the RStudio software Version 2022.02.1 . Results: Time series were analyzed using the R language and decomposed into their trend, seasonality and noise components. The seasonality graphs were isolated to understand the variation in the behavior of mortality from infectious diseases in the North Region when compared to data from Brazil distributed in the months of the year. Conclusion: Using RStudio, it was possible to analyze and decompose a large volume of data to build a 25-year time series, subdivided into monthly periods. Allowing the customization of graphic elements and their plotting.
Endodontic Treatment of a Deducted Lower Molar with Forca Injury, Root Reabsortion and Permanent Premolar Agenesis – Clinical Case Study
Authors: Souza Daniele Quintanilha , Quintanilha Iara Pereira , Barbosa Isabela Rodrigues , Marques Eduardo Fernandes
Published: November 2022

When the pathological process affects the dental pulp of the deciduous dental element and causes pulp inflammation or infection, endodontic treatment is indicated. The maintenance of the primary tooth is important, especially in cases of permanent tooth agenesis. The aim of this study is to report a clinical case about the endodontic treatment of a deciduous lower molar with furcation lesion, root resorption and permanent premolar agenesis. A patient was selected at the dental clinic of FAPAC/ITPAC (Porto Nacional) – TO, asymptomatic, negative sensitivity test and vertical percussion, incomplete root formation, radiolucent area in the furcation region in a deciduous lower molar and root resorption. In the first session, anesthesia, access surgery, absolute isolation, irrigation with 2.5% sodium hypochlorite, odontometry, instrumentation with K-files at working length, drying and insertion of intracanal medication (calcium hydroxide) were performed. In the second session (after 15 days), the intracanal medication was removed and the root canals were filled with mineral trioxide aggregate (MTA). Through the results obtained with the endodontic treatment, regression of the pathological process was noted during the proservations and the patient had no symptoms. Endodontic treatment in a primary first molar with a diagnosis of acute periradicular abscess is feasible for the conservation of the primary tooth. In this way, the absent permanent dental element performs its functions.
THE DIFFERENTIAL REDSHIFT OF TITANIUM LINES IN K STARS
Authors: Oostra B. , Vargas Muñoz P. C.
Published: November 2022

We present measurements of line core positions in UVES spectra of a sample of K-type stars, using the technique of bisector tracing. In all but two of these stars we detect an excess redshift of Ti I lines with respect to Fe I lines. We explain this invoking the temperature-dependence of the line depths. We conclude that the granulation curve is not unique but depends on the chemical species.
A VINDICATION OF THE RR LYRAE FOURIER LIGHT CURVE DECOMPOSITION FOR THE CALCULATION OF METALLICITY AND DISTANCE IN GLOBULAR CLUSTERS
Authors: Arellano A.
Published: November 2022

We report the mean metallicity and absolute magnitude of RR Lyrae stars in a sample of 37 globular clusters, calculated via the Fourier decomposition of their light curves and ad hoc semi-empirical calibrations, in an unprecedented homogeneous approach. This enabled a new discussion of the metallicity dependence of the horizontal branch (HB) luminosity, as a fundamental distance indicator. The calibration for the RRab and RRc stars should be treated separately. For the RRab the dispersion is larger and non-linear. For the RRc stars the correlation is less steep, very tight and linear. The relevance of the HB structural parameter L, is highlighted and we offer a non-linear calibration of the form MV ([Fe/H], L). Excellent agreement is found between values of [Fe/H] and MV from the light curve decomposition with spectroscopic values and distances obtained via Gaia-DR3 and HST. The variables census in 35 clusters includes 326 stars found by our program.
A STUDY OF THE NGC 1193 AND NGC 1798 OPEN CLUSTERS USING CCD UBV PHOTOMETRIC AND GAIA EDR3 DATA
Authors: Yontan T. , Çakmak H. , Bilir S. , Banks T. , Raúl M. , Canbay R. , Koç S. , Taşdemir S. , Erçay H. , Öztürk B. T. , Dursun D. C.
Published: November 2022

We present photometric, astrometric, and kinematic studies of the old open star clusters NGC 1193 and NGC 1798. Both of the clusters are investigated by combining data sets from Gaia Early Data Release 3 (EDR3) and CCD UBV observational data. E(B − V ) color excesses are derived for NGC 1193 as 0.150 ± 0.037 and for NGC 1798 as 0.505 ± 0.100 mag through the use of two-color diagrams. Photometric metallicities are also determined from two-color diagrams with the results of [Fe/H]=−0.30 ± 0.06 dex for NGC 1193 and [Fe/H]=−0.20 ± 0.07 dex for NGC 1798. The isochrone fitting distance and age of NGC 1193 are 5562 ± 381 pc and 4.6±1 Gyr, respectively. For NGC 1798, these parameters are 4451±728 pc and 1.3±0.2 Gyr. Kinematic and dynamic orbital calculations indicate that NGC 1193 and NGC 1798 belong to the thick-disk and thin-disk populations, respectively.
Literasi Buku Saku Pedoman Corporal Punishment Untuk Guru-Guru SMASMK Negeri se-Blitar Raya Dalam Mengantisipasi Kekerasan di Sekolah
Authors: Mahardhika Vita , Astuti Pudji , Rusdiana Emmilia , Hikmah Nurul , Ahmad Gelar Ali
Published: November 2022

Corporal punishment adalah hukuman yang diberikan untuk mendisiplinkan peserta didik dengan maksud memberikan rasa sakit tetapi tidak melukai, dengan tujuan membenahi atau mengontrol tingkah laku anak. Guru diberikan kewenangan untuk menjatuhkan corporal punishment, akan tetapi sedikit yang memahami bagaimana batasan dalam menjatuhkan corporal punishment kepada peserta didiknya. Hal ini dibuktikan dengan masih banyaknya kasus kekerasan yang dilakukan guru terhadap peserta didiknya. Tujuan pengabdian kepada masyarakat ini adalah memberikan literasi buku saku pedoman penjatuhan corporal punishment untuk guru-guru SMA/SMK Negeri se-Blitar Raya. Metode pelaksanaan pengabdian dilaksanakan dengan sarasehan dan diskusi dilanjutkan dengan tanya jawab. Hasil yang diperoleh dari kegiatan ini adalah pada guru memahami tentang pengertian, tujuan, tata cara dan batasan dalam penjatuhan corporal punishment sehingga tidak berpotensi ada pengaduan dari orang tua peserta didik kepada aparat penegak hukum.
Literacy Handbook of Corporal Punishment Guidelines for Senior High School/Vocational High School Teachers in Blitar Raya in Anticipating Violence in Schools
Corporal punishment is a punishment given to discipline students with the intention of giving pain but not injuring, with the aim of fixing or controlling the child's behavior. Teachers are given the authority to impose corporal punishment, but few understand how the limits are in imposing corporal punishment to their students. This is evidenced by the many cases of violence committed by teachers against their students. The purpose of this community service is to provide pocket book literacy guidelines for imposing corporal punishment for state high school/vocational teachers throughout Blitar Raya. The method of implementing the service is carried out with workshops and discussions followed by questions and answers. The results obtained from this activity are that the teacher understands the meaning, purpose, procedures and limitations in imposing corporal punishment so that there is no potential for complaints from parents of students to law enforcement officials.
Pemulihan Ekonomi Melalui Pemberdayaan Desa Berdasarkan Peraturan Gurbernur Nomor 20 Tahun 2021: Studi Dusun Kemlagi Kecamatan Kemlagi
Authors: Lina Lina , Pamungkas Jihan Tridho , Hariri Ahmad
Published: November 2022

Ekowisata merupakan perjalanan wisata yang memiliki tanggung jawab pada bidang pelestarian lingkungan dan kesejahteraan masyarakat yang ada di lingkungan setempat. Sumber Daya Manusia memiliki potensi yang sangat penting pada bidang ekowisata karena memperoleh pengetahuan alam dan berpotensi memiliki nilai jual sebagai bentuk daya minat dan daya tarik yang ada pada ekowisata. Perkembangan pada ekowisata dapat berpengaruh terhadap masyarakat pada bidang sosial, bidang ekologi, dan bidang ekonomi. Tujuan penelitian ini adalah dapat melakukan analisis pada perubahan kondisi ekonomi yang ada di dusun Kemlagi Kecamatan Kemlagi. Metode penelitian ini menggunakan jenis penelitian secara kualitatif menggunakan pendekatan studi literatur. Hasil penelitian ini menunjukan bahwa adanya kehadiran ekowisata pada masyarakat dusun Kemlagi memberikan sebuah perubahan terhadap masyarakat sehingga memiliki kesadaran dalam melindungi lingkungan dan ramah lingkungan. Pada aspek sosial terjadi sebuah peningkatan dan kerjasama masyarakat terutama pada bidang ekowisata. Kegiatan sosial yang ada pada masyarakat dapat sejalan sesuai dengan perkembangan pada ekowisata. Pada bidang ekonomi, terdapat kesempatan dalam bekerja pada sektor ekowisata sehingga dapat memperoleh penghasilan.
Economic Recovery Through Village Empowerment Based on Governor Regulation Number 20 of 2021: Study of Kemlagi Hamlet, Kemlagi District
Ecotourism is a tourism trip that has a responsibility in the field of environmental preservation and the welfare of the people in the local environment. Human Resources have very important potential in the field of ecotourism because they acquire natural knowledge and have the potential to have a selling value as a form of interest and attraction in ecotourism. Developments in ecotourism can affect the community in the social, ecological, and economic fields. The purpose of this study is to be able to analyze changes in economic conditions in the Kemlagi hamlet, Kemlagi District. This research method uses a qualitative research type using a literature study approach. The results of this study indicate that the presence of ecotourism in the Kemlagi hamlet community provides a change to the community so that they are aware of protecting the environment and being environmentally friendly. In the social aspect, there is an increase in community cooperation, especially in ecotourism. Social activities that exist in the community can be in line with developments in ecotourism. In the economic field, there are opportunities to work in the ecotourism sector to earn income.