bluuebunny/crossref_metadata_2025 huggingface dataset:
Current densities and total contact currents associated with 400 kV power line tasks
Authors: Korpinen Leena , Kuisti Harri , Elovaara Jarmo
Published: August 2013

The aim of the study was to analyze all current values from measured periods while performing tasks on 400 kV power lines. Our aim was also to study the average current densities and average total contact currents caused by electric fields in 400 kV power line tasks. Two workers simulated the following tasks: (A) climbing up a portal tower, (B) climbing up a portal transposing tower, (C) working on the cross‐arm of a portal tower, (D) climbing up a portal tube tower, (E) climbing up a Tannenbaum tower on the side of the energized circuit with the other circuit unenergized, (F) climbing up a Tannenbaum tower with both circuits energized, and (G) climbing up a Donau tower. The highest average current density in the neck was 2.5 mA/m2 (calculated internal electric field 31.5–63.0 mV/m), and the highest average of the contact currents was 240.0 µA. All measured values at 400 kV towers were lower than the limit value of 10 mA/m2 in the first version of Directive 2004/40/EC and the basic restrictions (0.1 and 0.8 V/m) of the International Commission on Non‐ionizing Radiation Protection. Bioelectromagnetics 34:641–644, 2013. © 2013 Wiley Periodicals, Inc.
Isoxanthohumol modulates angiogenesis and inflammation via vascular endothelial growth factor receptor, tumor necrosis factor alpha and nuclear factor kappa B pathways
Authors: Negrão Rita , Duarte Delfim , Costa Raquel , Soares Raquel
Published: August 2013

Angiogenesis and inflammation are becoming distinguished players in the pathogenesis of many heterogeneous diseases, such as diabetes, cardiovascular disease, and cancer. Therefore, it is crucial to study new compounds that are able to modulate these events. Isoxanthohumol (IXN) is a polyphenol with antioxidant, anti‐inflammatory, and antiangiogenic properties. The aim of this study was to evaluate the effects of IXN on blood vessel proliferation and maturation and describe underlying molecular mechanisms in endothelial cells (ECs) and vascular smooth muscle cells (VSMCs). Angiogenic profile of IXN was analyzed by retinal angiogenesis at different time points. IXN modulation of angiogenic and inflammatory signaling pathways was evaluated by Western blotting on EC and VSMC cultures. IXN inhibited by 20% sprouting angiogenesis and decreased vascular coverage by mural cells up to 39%. IXN of 10 µM also decreased inflammatory signals, namely tumor necrosis factor alpha (TNF‐α) (26 and 40%) and factor nuclear kappa B (24 and 42%) in human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs). Angiogenic regulators, including vascular endothelial growth factor receptor 2 (HUVEC, 55%), angiopoietins 1 (HUVEC, 39%; HASMC, 35%), angiopoietin 2 (HUVEC, 38%), and Tie2 (HUVEC, 56%) were also inhibited by 10 µM of IXN treatments. Akt activation was reduced by 47% in HUVEC‐treated cells and Erk activation was also reduced by 52 and 69% upon IXN treatment of HUVEC and HASMC. IXN seems to regulatein vivovascular proliferation and stabilization and the EC–VSMC–inflammatory crosstalk, leaving this molecule as an interesting nutritional player for angiogenesis and inflammation‐related diseases. © 2013 BioFactors, 39(6):608–622, 2013
ChemInform Abstract: Studies on Solid Solutions Based on Layered Honeycomb‐Ordered Phases P2—Na2M2TeO6 (M: Co, Ni, Zn).
Authors: Berthelot Romain , Schmidt Whitney , Sleight A. W. , Subramanian M. A.
Published: August 2013

Solid solutions Na2Ni2‐xZnxTeO6, Na2Ni2‐xCoxTeO6, and Na2Co2‐xZnxTeO6 (0 ≤ x ≤ 2) are prepared by solid state reaction of appropriate mixtures of Na2CO3, NiO, Co3O4, ZnO, and TeO2 (Au crucible, 900 °C, 24 h).
ChemInform Abstract: Strong Blue and White Photoluminescence Emission of BaZrO3 Undoped and Lanthanide Doped Phosphor for Light Emitting Diodes Application.
Authors: Romero V. H. , De la Rosa E. , Salas P. , Velazquez‐Salazar J. J.
Published: August 2013

Perovskite BaZrO3:Tm3+ submicron crystals are prepared from aqueous mixtures of Ba(NO3)2 and ZrCl2 as host precursors, TmCl3 as dopant, cetyl trimethylammonium bromide, EtOH, and NaOH (autoclave, 100 °C, 24 h; annealing in air at 1000 °C, 3 h).
ChemInform Abstract: Extending the Family of Oxygen Ion Conductors Isostructural with La2Mo3O9.
Authors: Voronkova V. I. , Kharitonova E. P. , Orlova E. I. , Belov D. A.
Published: August 2013

X‐ray diffraction shows that compounds isostructural with the oxygen ion conductor La2Mo2O9 exist in the ternary systems La2Mo2O9—Nd2W2 O9—Nd2Mo2O9 and La2Mo2O9—Pr2W2 O9—Pr2Mo2O9 over wide single‐phase regions.
ChemInform Abstract: The First Tetradentate μ‐1ϰ2:2ϰ2‐Sn2Se6 Ligand to a Lanthanide(III) Center: Solvothermal Syntheses and Characterizations of Lanthanide Selenidostannate Polymers with Tetraethylenepentamine as a Second Ligand.
Authors: Tang Weiwei , Chen Ruihong , Jiang Wenqing , Zhang Yong , Jia Dingxian
Published: August 2013

Compounds (IV) and (VIII) crystallize in the monoclinic space group C2/c with Z = 4.
ChemInform Abstract: Bi6(SeO3)3O5Br2: A New Bismuth Oxo‐Selenite Bromide.
Authors: Berdonosov Peter S. , Olenev Andrei V. , Kirsanova Maria A. , Lebed Julia B. , Dolgikh Valery A.
Published: August 2013

The title compound is synthesized by reaction of BiOBr, Bi2O3 and SeO2 (sealed quartz tube, 475 °C, 60 h).
ChemInform Abstract: Enantioselective Synthesis of α‐Alkyl‐β‐ketoesters: Asymmetric Roskamp Reaction Catalyzed by an Oxazaborolidinium Ion.
Authors: Gao Lizhu , Kang Byung Chul , Hwang Geum‐Sook , Ryu Do Hyun
Published: August 2013

A catalytic route toward chiral α‐alkyl‐β‐ketoesters using the title reaction of α‐alkyl diazoester with aldehydes is developed.
ChemInform Abstract: Simplified Procedure for TEMPO‐Catalyzed Oxidation: Selective Oxidation of Alcohols, α‐Hydroxy Esters, and Amides Using TEMPO and Calcium Hypochlorite.
Authors: Reddy Sabbasani Rajasekhara , Stella Selvaraj , Chadha Anju
Published: August 2013

The method presented does not require any transition metals, acids or bases and demonstrates controlled and selective oxidation of structurally diverse alcohols.
ChemInform Abstract: Gallium Tribromide Catalyzed Coupling Reaction of Alkenyl Ethers with Ketene Silyl Acetals.
Authors: Nishimoto Yoshihiro , Ueda Hiroki , Yasuda Makoto , Baba Akio
Published: August 2013

The title reaction is accomplished for various types of alkenyl ethers and ketene silyl acetals.
ChemInform Abstract: Diastereoselective Liquid Assisted Grinding: “Cracking” Functional Resins to Advance Chromatography‐Free Synthesis.
Authors: Shearouse William C. , Mack James
Published: August 2013

The report details the use of ball milling and the use of a polymer‐bound reagent to perform an evironmentally attractive version of the Wittig‐reaction.
ChemInform Abstract: Multidirectional Cobalt‐Catalyzed Diels—Alder/1,4‐Hydrovinylation Sequences.
Authors: Erver Florian , Kuttner Julian R. , Hilt Gerhard
Published: August 2013

CoBr2(dppe)‐catalyzed treatment of enynes of type (I) with the diene (II) followed by oxidation is found to result in formation of polysubstituted benzenes like (III).
ChemInform Abstract: Triphenylphosphine as a Ligand for the Pd‐Catalyzed Amination of Unactivated Aryl Chlorides with Anilines Promoted by Salicylaldimine.
Authors: Liu Tao‐Ping , Cheng Qiang , Song Wen‐Jing , Cai Liang‐Zhen , Tao Xiao‐Chun
Published: August 2013

The selective amination of aryl chlorides with anilines for the preparation of diarylamines is catalyzed by a mixed ligand catalytic system of Pd/PPh3/salicylaldimine.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Homoenolate‐Addition Reaction of Enals and Nitroalkenes: Asymmetric Synthesis of 5‐Carbon‐Synthon δ‐Nitroesters.
Authors: Maji Biswajit , Ji Li , Wang Siming , Vedachalam Seenuvasan , Ganguly Rakesh , Liu Xue‐Wei
Published: August 2013

The title reaction employs catalytic amounts of N‐heterocyclic carbene precursors and transforms a broad range of nitroalkenes, such as nitrodienes, nitroenynes, and nitrostyrenes, through reaction with a broad range of enals, into δ‐nitroesters.
ChemInform Abstract: 1‐(α‐Aminobenzyl)‐2‐naphthol as Phosphine‐Free Ligand for Pd‐Catalyzed Suzuki and One‐Pot Wittig—Suzuki Reaction.
Authors: Chaudhary A. R. , Bedekar A. V.
Published: August 2013

An air stable and easily accessible ligand is successfully applied to the Suzuki reaction for a variety of substrates and to a novel and efficient one‐pot two‐step cascade Wittig‐Suzuki reaction.
ChemInform Abstract: Suzuki—Miyaura Coupling of Aryl Iodides, Bromides, and Chlorides Catalyzed by Bis(thiazole) Pincer Palladium Complexes.
Authors: Luo Qun‐Li , Tan Jian‐Ping , Li Zhi‐Fu , Nan Wen‐Hui , Xiao Dong‐Rong
Published: August 2013

Using the title method, the key intermediate (VIII) of the luteinizing hormone receptor antagonist LUF5771 can be prepared in high yields.
ChemInform Abstract: Novel Task‐Specific Ionic Liquids as Solvents for Michael Addition of Methylene Active Compounds to Chalcones Without Any Catalyst.
Authors: Ying An‐Guo , Chen Xin‐Zhi , Wu Cheng‐Lin , Zheng Ren‐Hua , Liang Hua‐Ding , Ge Chang‐Hua
Published: August 2013

A convenient and facile method for the Michael addition of active methylene compounds to chalcones is developed using DBU‐derived task‐specific ionic liquids as reaction medium.
ChemInform Abstract: Asymmetric Epoxidation of Conjugated Olefins with Dioxygen.
Authors: Koya Shota , Nishioka Yota , Mizoguchi Hirotaka , Uchida Tatsuya , Katsuki Tsutomu
Published: August 2013

The asymmetric epoxidation of conjugated olefins is achieved at room temperature using an (aqua)ruthenium(salen) complex as catalyst and air as the oxidant to give epoxides in up to 95% e.e.
ChemInform Abstract: Direct Asymmetric Vinylogous Mannich Reaction of 3,4‐Dihalofuran‐2(5H)‐one with Aldimine Catalyzed by Quinine.
Authors: Guo Yun‐Long , Bai Jian‐Fei , Peng Lin , Wang Liang‐Liang , Jia Li‐Na , Luo Xi‐Ya , Tian Fang , Xu Xiao‐Ying , Wang Li‐Xin
Published: August 2013

Furanones of type (III) are useful synthons which can be converted into optically active butyrolactones such as (IV) and amino diols like (V).
ChemInform Abstract: CuO/CNTs‐Catalyzed Heterogeneous Process: A Convenient Strategy to Prepare Furan Derivatives from Electron‐Deficient Alkynes and α‐Hydroxy Ketones.
Authors: Cao Hua , Jiang Huan‐Feng , Zhou Xiao‐Song , Qi Chao‐Rong , Lin Yuan‐Guang , Wu Jian‐Yong , Liang Qi‐Mei
Published: August 2013

Carbon nanotube supported CuO is synthesized and applied as highly active and reusable heterogeneous catalyst for the construction of highly substituted furan derivatives (III).
ChemInform Abstract: Novel and Convenient Synthesis of Benzofurans from Dihydrocoumarins.
Authors: Shachan‐Tov Sharona , Frimer Aryeh A.
Published: August 2013

Benzofurans (VII) are unexpectedly synthesized from coumarins (III) through esters (V).
ChemInform Abstract: Asymmetric Synthesis of 2‐Arylpyrrolidines by Cationic Cyclization.
Authors: Coldham Iain , Robinson Steven P. , Baxter Carl A.
Published: August 2013

Asymmetric deprotonation of benzylamines (I) yields chiral organolithiums to which prenyl bromide (II) is added.
ChemInform Abstract: Deciphering DNA‐Based Asymmetric Catalysis Through Intramolecular Friedel—Crafts Alkylations.
Authors: Park Soyoung , Ikehata Keiichi , Watabe Ryo , Hidaka Yuta , Rajendran Arivazhagan , Sugiyama Hiroshi
Published: August 2013

The combination of DNA and a copper‐phenanthroline complex is tested as a catalytic system for the asymmetric intramolecular Friedel—Crafts alkylation of indoles (I).
ChemInform Abstract: One‐Pot Approach to Installing Eight‐Membered Rings onto Indoles.
Authors: Zhu Can , Zhang Xue , Lian Xiongdong , Ma Shengming
Published: August 2013

One‐pot procedure for the synthesis of dihydrocycloocta[b]indoles from 2‐allyl‐3‐iodoindoles and propargyl bromides proceeds through Pd‐catalyzed C—C coupling, [1,5]hydrogen migration and electrocyclization.
ChemInform Abstract: A Practical and Efficient Synthesis of 2,5‐Disubstituted‐3,5‐dihydro‐imidazol‐4‐ones from Oxazolones.
Authors: Chavez Flavio , Pavy Caslin , Williamson Thomas , Cleary Thomas
Published: August 2013

A practical and efficient method for the synthesis of 2,5‐disubstituted‐3,5‐dihydro‐imidazol‐4‐ones (II) is developed.
ChemInform Abstract: Enantioselective Conjugate Addition of Alkylboranes Catalyzed by a Copper—N‐Heterocyclic Carbene Complex.
Authors: Yoshida Mika , Ohmiya Hirohisa , Sawamura Masaya
Published: August 2013

For the first time the title reaction is developed in a catalytic manner by using a new chiral imidazolium salt.
ChemInform Abstract: Synthesis and Evaluation of Some Novel 2,4‐Thiazolidinedione Derivatives for Antibacterial, Antitubercular and Antidiabetic Activities.
Authors: Pattan Shashikant , Kedar Manisha , Pattan Jayashri , Dengale Santosh , Sanap Manjusha , Gharate Utkarsha , Shinde Punam , Kadam Sushma
Published: August 2013

All of the synthesized thiazolidinedione (IX) and (XI) show promising antibacterial, antitubercular and antidiabetic activities in comparison to the standard drugs norfloxacin, streptomycin and glibenclamide, respectively.
ChemInform Abstract: Synthesis, Characterization and Structure Optimization of a Series of Thiazolidinone Derivatives as Entamoeba histolytica Inhibitors.
Authors: Mushtaque Md. , Avecilla Fernando , Azam Amir
Published: August 2013

Thiazolidinone derivatives (V) are synthesized and evaluated for their in vitro antiamoebic activity against the HM1:IMSS strain of Entamoeba histolytica. Compounds (V) exhibit promising potency with IC50 values lower than the standard drug metronidazole.
ChemInform Abstract: Ligand‐Free Copper Powder Catalyzed Direct Coupling Reaction of Heterocyclic C—H Bonds and Aryl Halides.
Authors: Han Ying , Wang Xiaohu , Wang Xiaowei , Lv Liangzhong , Diao Guowang , Yuan Yu
Published: August 2013

Benzothiazole (II) and benzoxazole (VI) can be efficiently coupled with aryl iodides under optimized conditions A).
ChemInform Abstract: Asymmetric Syntheses of 8‐Oxabicyclo[3,2,1]octanes: A Cationic Cascade Cyclization.
Authors: Li Bin , Zhao Yu‐Jun , Lai Yin‐Chang , Loh Teck‐Peng
Published: August 2013

A novel, practical, mild, and efficient diastereoselective synthesis of the title compounds is developed.
ChemInform Abstract: New Syntheses of 3‐Aroylflavone Derivatives; Knoevenagel Condensation and Oxidation versus One‐Pot Synthesis.
Authors: Vaz Patricia A. A. M. , Pinto Diana C. G. A. , Rocha Djenisa H. A. , Silva Artur M. S. , Cavaleiro Jose A. S.
Published: August 2013

Two methodologies are developed to perform the synthesis of 3‐aroylflavones.
ChemInform Abstract: Palladium‐Catalyzed Domino Carbopalladation/C—H Activation for the Synthesis of Tetrasubstituted Alkenes Bearing Five‐ and Seven‐Membered Rings.
Authors: Tietze Lutz F. , Hungerland Tim , Depken Christian , Maass Christian , Stalke Dietmar
Published: August 2013

Propargylic alcohols (I) afford tetrasubstituted alkenes having a dihydroindene‐ or a benzo[7]annulene motif.
ChemInform Abstract: Synthesis and Evaluation of Novel 2‐Pyridone Derivatives as Inhibitors of Phosphodiesterase3 (PDE3): A Target for Heart Failure and Platelet Aggregation.
Authors: Ravinder Mettu , Mahendar Budde , Mattapally Saidulu , Hamsini Kommi Venkata , Reddy Thatikonda Narendar , Rohit Chilappa , Srinivas Kolupula , Banerjee Sanjay Kumar , Rao Vaidya Jayathirtha
Published: August 2013

26 Pyridone derivatives of type (IV) are prepared and tested as inhibitors of phosphodiesterase3 (PDE3).
ChemInform Abstract: Design, Solvent Free Synthesis, and Antimicrobial Evaluation of 1,4‐Dihydropyridines.
Authors: Murthy Y. L. N. , Rajack Abdul , Ramji M. Taraka , Jeson babu J. , Praveen Ch. , Lakshmi K. Aruna
Published: August 2013

Optimum reaction conditions are examined for the synthesis of 1,4‐dihydropyridines using cellulose sulfuric acid as catalyst.
ChemInform Abstract: Synthesis and Cytotoxicity of New Quinoline Derivatives.
Authors: Meshram H. M. , Reddy B. Chennakesava , Kumar D. Aravind , Kalyan M. , Ramesh P. , Kavitha P. , Rao J. Venkateswara
Published: August 2013

The title compounds are obtained from 4‐haloquinoline (I) following the Suzuki protocol.
ChemInform Abstract: Copper‐Catalyzed Tandem Synthesis of Indolo‐, Pyrrolo[2,1‐a]isoquinolines, Naphthyridines and Bisindolo/Pyrrolo[2,1‐a]isoquinolines via Hydroamination of ortho‐Haloarylalkynes Followed by C‐2 Arylation.
Authors: Verma Akhilesh K. , Jha Rajeev R. , Chaudhary Ritu , Tiwari Rakesh K. , Reddy Kotla Siva K. , Danodia Abhinandan
Published: August 2013

The title compounds are of biological and electronic interest.
ChemInform Abstract: Copper‐Catalyzed Aerobic Dehydrogenative Cyclization of N‐Methyl‐N‐phenylhydrazones: Synthesis of Cinnolines.
Authors: Zhang Guangwu , Miao Jinmin , Zhao Yan , Ge Haibo
Published: August 2013

N‐Phenylhydrazones as novel substrates for copper‐catalyzed aerobic intramolecular dehydrogenative cyclization are presented.
ChemInform Abstract: Ring Opening of Cyclic Sulfamidates with Magnesiated Heterocycles: Expedient Synthesis of Highly Functionalized Azaindolines and Azatetrahydroquinolines.
Authors: Moss Thomas A. , Hayter Barry R. , Hollingsworth Ian A. , Nowak Thorsten
Published: August 2013

Azaindolines (III) and azatetrahydroquinolines (V) are prepared in a stereo‐predictable manner via ring opening of cyclic sulfamidates with metalated chloro heterocycles, followed by intramolecular cyclization upon basification of the adducts.
ChemInform Abstract: Vanadium‐Catalyzed Oxidation of tert‐Butyl N‐Hydroxycarbamate to tert‐Butyl Nitrosoformate and Its Diels—Alder Reaction with Simple and Functionalized Dienes.
Authors: Hoshino Yujiro , Suzuki Kenzo , Honda Kiyoshi
Published: August 2013

The vanadium‐catalyzed oxidation of carbamate (II), followed by alkyl hydroperoxides as terminal oxidants, affords an intermediate nitroso compound.
ChemInform Abstract: Synthesis of 4‐Aryl‐4‐methyl‐ and 4,4‐Dimethyl‐4H‐pyrrolo[2,1‐c][1,4]benzothiazines by an Easy Five‐Step Sequence Starting from 2‐Sulfanylbenzenamines.
Authors: Kobayashi Kazuhiro , Hyota Akane , Kondo Hideaki , Imaoka Ayumi
Published: August 2013

Precursor (XII) is prepared analogously to (VII) following the sequence A)‐D).
ChemInform Abstract: 1‐(2‐Mercaptobenzenesulfonyl)‐3‐hydroxyguanidines — Novel Potent Antiproliferatives, Synthesis and in vitro Biological Activity.
Authors: Brozewicz Kamil , Slawinski Jaroslaw
Published: August 2013

A series of novel 1‐(2‐mercaptobenzenesulfonyl)‐3‐hydroxyguanidines like (VIII) or (XII) is synthesized and evaluated for their in vitro anticancer activity.
ChemInform Abstract: Intermolecular Gold‐Catalyzed Diastereo‐ and Enantioselective [2 + 2 + 3] Cycloadditions of 1,6‐Enynes with Nitrones.
Authors: Gawade Sagar Ashok , Bhunia Sabyasachi , Liu Rai‐Shung
Published: August 2013

Racemic and enantioenriched polycyclic compounds are constructed from benzoid and nonbenzoid 1,6‐enynes and nitrones.
ChemInform Abstract: Highly Regio‐ and Stereoselective Hydrophosphinylation of Acetylenes with Diphenylphosphine Oxide Catalyzed by Immobilization of Rhodium in MCM‐41.
Authors: Huang Yixiang , Hao Wenyan , Ding Guodong , Cai Ming‐Zhong
Published: August 2013

A variety of (E)‐alkenylphosphine oxides are obtained in good to excellent yields in the presence of immobilized rhodium catalyst MSR.
ChemInform Abstract: Catalyst‐ and Solvent‐Free, Ultrasound‐Promoted Rapid Protocol for the One‐Pot Synthesis of α‐Aminophosphonates at Room Temperature.
Authors: Dar Bashir , Singh Amrinder , Sahu Akshya , Patidar Praveen , Chakraborty Arup , Sharma Meena , Singh Baldev
Published: August 2013

The simple three‐component process allows an access to various title compounds as analogues of amino acids in good to excellent yields.
ChemInform Abstract: Three New Resin Glycosides and a New Tetrahydropyran Derivative from the Seeds of Quamoclit pennata.
Authors: Ono Masateru , Takaki Yoshinari , Takatsuji Masamitsu , Akiyama Kousuke , Okawa Masafumi , Kinjo Junei , Miyashita Hiroyuki , Yoshimitsu Hitoshi , Nohara Toshihiro
Published: August 2013

[isolation and structure determination of four new resin glycosides quamoclins V—VII [cf.
ChemInform Abstract: Preparation of Benzoate Esters of Morphine and Its Derivatives
Authors: Beni Szabolcs , Toth Gergoe , Noszal Bela , Hosztafi Sandor
Published: August 2013

21 examples
ChemInform Abstract: New High‐Temperature Pb‐Catalyzed Synthesis of Inorganic Nanotubes.
Authors: Brontvein Olga , Stroppa Daniel G. , Popovitz‐Biro Ronit , Albu‐Yaron Ana , Levy Moshe , Feuerman Daniel , Houben Lothar , Tenne Reshef , Gordon Jeffrey M.
Published: August 2013

MoS2, MoSe2, WS2, and WSe2 nanotubes are prepared by irradiation of 1:1 molar mixtures of MoS2, MoSe2, WS2, or WSe2 and Pb/PbO with highly concentrated solar beam radiation and exposure times of 30—1200 s.
ChemInform Abstract: An Environmentally Friendly Method for the Synthesis of Nano‐Alumina with Controllable Morphologies.
Authors: Liu Chengchao , Li Jinlin , Liew Kongyong , Zhu Junjiang , bin Nordin Mohd Ridzuan
Published: August 2013

Alumina nanostructures are prepared by dropwise addition of an aqueous (NH4)2CO3 solution to Al(NO3)3 dissolved in EtOH (1.
ChemInform Abstract: Identification of (R)‐N‐(4‐(4‐Methoxyphenyl)thiazol‐2‐yl) ‐1‐tosylpiperidine‐2‐carboxamide, ML277, as a Novel, Potent and Selective Kv7.1 (KCNQ1) Potassium Channel Activator.
Authors: Hopkins Corey R. , et al. et al.
Published: August 2013

Compound (I) is identified as a potent activator of KCNQ1 channels using a high‐throughput screen of the NIH Molecular Library Small Molecule Repository.
ChemInform Abstract: Chan—Lam Coupling Reactions: Synthesis of Heterocycles
Authors: Rao Kodepelly Sanjeeva , Wu Tian‐Shung
Published: August 2013

Review: [125 refs.]
ChemInform Abstract: Synthetic Studies on Natural Pterin Glycosides
Authors: Hanaya Tadashi , Yamamoto Hiroshi
Published: August 2013

Review: 45 refs.
ChemInform Abstract: Adamantane Functionalization. Synthesis of Polyfunctional Derivatives with Various Substituents in Bridgehead Positions
Authors: Shokova E. A. , Kovalev V. V.
Published: August 2013

Review: 94 refs.
ChemInform Abstract: Gold in Total Synthesis: Alkynes as Carbonyl Surrogates
Authors: Brenzovich William E. Jr.
Published: August 2013

Review: 30 refs.
ChemInform Abstract: “Black Swan Events” in Organic Synthesis
Authors: Nugent William A.
Published: August 2013

Review: developments of ten examples of conventional organic syntheses are traced from 1976 till today; ca. 160 refs.
ChemInform Abstract: A “Renaissance” in Radical Trifluoromethylation.
Authors: Studer Armido
Published: August 2013

Review: 105 refs.
ChemInform Abstract: Nanoporous Metals: Fabrication Strategies and Advanced Electrochemical Applications in Catalysis, Sensing and Energy Systems
Authors: Zhang Jintao , Li Chang Ming
Published: August 2013

Review: 92 refs.
ChemInform Abstract: Magnetism on a Mesoscopic Scale: Molecular Nanomagnets Bridging Quantum and Classical Physics
Authors: Konstantinidis Nikolaos P. , Sundt Alexander , Nehrkorn Joscha , Machens Anna , Waldmann Oliver
Published: August 2013

Review: 82 refs.
ChemInform Abstract: Mutual Interactions Between Flavonoids and Enyzmatic and Transporter Elements Responsible for Flavonoid Disposition via Phase II Metabolic Pathways.
Authors: Jiang Wen , Hu Ming
Published: August 2013

Review: 161 refs.
ChemInform Abstract: Layer‐by‐Layer Self‐Assembly in the Development of Electrochemical Energy Conversion and Storage Devices from Fuel Cells to Supercapacitors
Authors: Xiang Yan , Lu Shanfu , Jiang San Ping
Published: August 2013

Review: 250 refs.
ChemInform Abstract: Transition Metal Catalysis by Density Functional Theory and Density Functional Theory/Molecular Mechanics
Authors: Sameera W. M. C. , Maseras Feliu
Published: August 2013

Review: 57 refs.
ChemInform Abstract: Fluorescent Labeling Techniques in Biomolecules: A Flashback
Authors: Sahoo Harekrushna
Published: August 2013

Review: 112 refs.
Design and Synthesis of Fluoroacylshikonin as an Anticancer Agent
Authors: Kong Wen‐Yao , Chen Xiao‐Feng , Shi Jing , Baloch Shahla Karim , Qi Jin‐Liang , Zhu Hai‐Liang , Wang Xiao‐Ming , Yang Yong‐Hua
Published: August 2013

A series of shikonin derivatives, selectively acylated by various fluorinated carboxylic acids at the side chain of shikonin, were synthesized and their anticancer activity evaluated, in which eight compounds are reported for the first time. Among all the compounds tested, compound S7 showed the most potent anticancer activity against B16‐F10 (malignant melanoma cells), MG63 (human osteosarcoma cells), and A549 (lung cancer cells) with IC50 0.39 ± 0.01, 0.72 ± 0.04 and 0.58 ± 0.02 µmol/L. Docking simulation of compound S7 was carried out to position S7 into a tubulin active site to determine the probable binding conformation. All the results suggested that compound S7 may be a potential anticancer agent. Chirality 25:757–762, 2013. © 2013 Wiley Periodicals, Inc.
Cytopathologic diagnosis on joint lavage fluid for patients with temporomandibular joint disorders
Authors: Mikami Toshinari , Kumagai Akiko , Aomura Tomoyuki , Javed Fawad , Sugiyama Yoshiki , Mizuki Harumi , Takeda Yasunori
Published: August 2013

Temporomandibular joint (TMJ) disorders (TMD) are usually diagnosed based on the patient's clinical findings and the results of image investigations; however, understanding of the inflammatory process in TMJ is difficult. In addition, many of the TMJ disease types share common principal symptoms. Therefore, TMJ diseases in the early stage can be misdiagnosed with TMD. It is hypothesized that cytopathologic examination of the joint lavage fluids is useful in interpreting the TMD‐associated inflammatory process from a cellular aspect. The aim of this study was to assess the TMJ lavage fluid cytopathologically in TMD patients. Thirty‐nine patients, clinically diagnosed as TMD, were included in the present study. Clinical symptoms of the patients were recorded. Forty‐four samples of TMJ lavage fluid were collected and paraffin‐embedded cell sections were made by cell block tissue array method. Cytologic conditions in upper articular cavity of TMJ were cytopathologically diagnosed and were compared with the clinical symptoms of each patient. Cell components were detected in 22 of the 44 analyzed joint lavage fluids. There was a correlation between cytopathologic findings and clinical symptoms. Variety of cytopathology and inflammatory conditions in patients with similar clinical symptoms were also found. The results suggested that cytopathologic examination of the joint lavage fluids from TMD patients is helpful for gaining an understanding of the inner local conditions of TMJ at the cellular level. Diagn. Cytopathol. 2014;42:30–36. © 2013 Wiley Periodicals, Inc.
Comparative study of the cervista and hybrid capture 2 methods in detecting high‐risk human papillomavirus in cervical lesions
Authors: Tao Kun , Yang Jing , Yang Hua , Guo Zhen‐Hua , Hu Yue‐Mei , Tan Zhen‐Yu , Zhang Feng , Duan Jin‐Lin
Published: August 2013

High‐risk human papillomavirus (HR HPV) testing is important for the follow‐up of patients with cytological abnormalities. This study was undertaken to compare the clinical value of the Cervista and hybrid capture 2 (HC2) tests for detection of HR HPV in cervical lesions. Overall 439 cervical specimens with abnormal cytology and 22 normal cervical specimens were subjected to the Cervista and HC2 tests. HPV positivity and its predictive value for high‐grade cervical lesions were assessed. The Cervista and HC2 tests showed comparable HR HPV detection rates in women with all cytological and histological diagnoses, with a positive and negative percent agreement of 90.8% and 64.5%, respectively. The two methods had a same sensitivity of 90% in detecting CIN II or greater cervical lesions, while the specificity for the Cervista test and HC2 assay was 47% and 43%, respectively. The positive rate for the Cervista assay probe set A9 increased with the histological severity, ranging from 25.0% in normal specimens to 69.5% in high‐grade lesions. In conclusion, the clinical performance for the Cervista test is as excellent as the HC2 test in detecting HR HPV and predicting high‐grade cervical lesions. Diagn. Cytopathol. 2014;42:213–217. © 2013 Wiley Periodicals, Inc.
Utility of ProExC and IMP3 immunocytochemical staining in atypical glandular cells of undetermined significance in liquid‐based cervical cytology
Authors: Lastra Ricardo R. , Ou Joyce J. , Reilly Mary E. , Lawrence W. Dwayne , Baloch Zubair W. , Brooks John S. , Barroeta Julieta E.
Published: August 2013

The diagnosis of atypical glandular cells of undetermined significance (AGUS) in liquid‐based cervical cytology specimens shows significant underlying pathology in only 30% of cases, while the remaining cases are found to be benign (reactive, reparative/metaplastic). Previous studies have reported positive ProExC and IMP3 staining in neoplastic glandular lesions of the uterine cervix and corpus. We present our experience with the utility of these markers in the evaluation of AGUS cases in liquid‐based cervical cytology. The case cohort included 34 cases diagnosed as AGUS. ProExC and IMP3 immunocytochemical (ICC) stains were performed on ThinPrep® slides and the results correlated with subsequent biopsy findings. Positive expression was classified as strong diffuse nuclear immunostaining for ProExC and granular cytoplasmic for IMP3. The presence of AGUS cells on the ICC stained slides was confirmed in all cases. IMP3 was positive in 80% of glandular neoplasms and negative in 93% non‐glandular lesions/cases negative for squamous intraepithelial lesion (SIL). ProExC was positive in 60% of glandular neoplasms and negative in 83% non‐glandular lesions/cases negative for SIL. When used as a panel (ProExC + IMP3), at least one stain was positive in 100% of glandular neoplasm cases and they were both negative in 83% of non‐glandular lesions/cases negative for SIL. Based on this study, both ProExC and IMP3, when used as an immuno panel, can predict the presence of glandular lesions on subsequent biopsies and can serve as an aid in the diagnosis and management of AGUS cases. Diagn. Cytopathol. 2014;42:375–379. © 2013 Wiley Periodicals, Inc.
FNA diagnosis of a metastatic papillary thyroid carcinoma arising from a previously unknown follicular variant of papillary thyroid microcarcinoma
Authors: Jedrzkiewicz Jolanta , Witt Benjamin L.
Published: August 2013

While metastatic tumors to bone or lymph nodes from previously known primaries are often successfully diagnosed via fine‐needle aspiration (FNA), a metastatic deposit in a patient with no previously known cancer may pose a diagnostic dilemma. Here, we present a case of metastatic papillary thyroid carcinoma that presented initially as a large pelvic bone mass. FNA was performed on this mass. The diagnosis was challenging due the fact that the tumor did not display the classic nuclear features associated with papillary thyroid carcinoma, instead the nuclear morphology was in keeping with a follicular thyroid carcinoma. Given the patient's concurrent, unremarkable thyroid imaging studies the final diagnosis required an extensive immunohistochemical work‐up. Diagn. Cytopathol. 2014;42:711–715. © 2013 Wiley Periodicals, Inc.
Prickle1 stunts limb growth through alteration of cell polarity and gene expression
Authors: Yang Tian , Bassuk Alexander G. , Fritzsch Bernd
Published: August 2013

Background: Wnt/PCP signaling plays a critical role in multiple developmental processes, including limb development. Wnt5a, a ligand of the PCP pathway, signals through the Ror2/Vangl2 or the Vangl2/Ryk complex to regulate limb development along the proximal‐distal axis in mice. Based on the interaction between Van Gogh and Prickle in Drosophila, we hypothesized the vertebrate Prickle1 has a similar function as Vangl2 in limb development. Results: We show Prickle1 is expressed in the skeletal condensates that will differentiate into chondrocytes and later form bones. Disrupted Prickle1 function in Prickle1C251X/C251X mouse mutants alters expression of genes such as Bmp4, Fgf8, Vangl2, and Wnt5a. These expression changes correlate with shorter and wider bones in the limbs and loss of one phalangeal segment in digits 2–5 of Prickle1C251X mutants. These growth defects along the proximal‐distal axis are also associated with increased cell death in the growing digit tip, reduced cell death in the interdigital membrane, and disrupted chondrocyte polarity. Conclusions: We suggest Prickle1 is part of the Wnt5a/PCP signaling, regulating cell polarity and affecting expression of multiple factors to stunt limb growth through altered patterns of gene expression, including the PCP genes Wnt5a and Vangl2. Developmental Dynamics 242:1293–1306, 2013. © 2013 Wiley Periodicals, Inc.
Nonconsumptive effects in a multiple predator system reduce the foraging efficiency of a keystone predator
Authors: Davenport Jon M. , Chalcraft David R.
Published: August 2013

Many studies have demonstrated that the nonconsumptive effect (NCE) of predators on prey traits can alter prey demographics in ways that are just as strong as the consumptive effect (CE) of predators. Less well studied, however, is how the CE and NCE of multiple predator species can interact to influence the combined effect of multiple predators on prey mortality. We examined the extent to which the NCE of one predator altered the CE of another predator on a shared prey and evaluated whether we can better predict the combined impact of multiple predators on prey when accounting for this influence. We conducted a set of experiments with larval dragonflies, adult newts (a known keystone predator), and their tadpole prey. We quantified the CE and NCE of each predator, the extent to which NCEs from one predator alters the CE of the second predator, and the combined effect of both predators on prey mortality. We then compared the combined effect of both predators on prey mortality to four predictive models. Dragonflies caused more tadpoles to hide under leaf litter (a NCE), where newts spend less time foraging, which reduced the foraging success (CE) of newts. Newts altered tadpole behavior but not in a way that altered the foraging success of dragonflies. Our study suggests that we can better predict the combined effect of multiple predators on prey when we incorporate the influence of interactions between the CE and NCE of multiple predators into a predictive model. In our case, the threat of predation to prey by one predator reduced the foraging efficiency of a keystone predator. Consequently, the ability of a predator to fill a keystone role could be compromised by the presence of other predators.
Speciation patterns and processes in the zooplankton of the ancient lakes of Sulawesi Island, Indonesia
Authors: Vaillant James J. , Bock Dan G. , Haffner G. Douglas , Cristescu Melania E.
Published: August 2013

Although studies of ancient lake fauna have provided important insights about speciation patterns and processes of organisms in heterogeneous benthic environments, evolutionary forces responsible for speciation in the relatively homogenous planktonic environment remain largely unexplored. In this study, we investigate possible mechanisms of speciation in zooplankton using the freshwater diaptomids of the ancient lakes of Sulawesi, Indonesia, as a model system. We integrate phylogenetic and population genetic analyses of mitochondrial and nuclear genes with morphological and genome size data. Overall, our results support the conclusion that colonization order and local adaptation are dominant at the large, island scale, whereas at local and intralacustrine scales, speciation processes are regulated by gene flow among genetically differentiated and locally adapted populations. In the Malili lakes, the diaptomid populations are homogenous at nuclear loci, but show two highly divergent mitochondrial clades that are geographically restricted to single lakes despite the interconnectivity of the lake systems. Our study, based on coalescent simulations and population genetic analyses, indicates that unidirectional hybridization allows gene flow across the nuclear genome, but prevents the introgression of mitochondria into downstream populations. We suggest that hybridization and introgression between young lineages is a significant evolutionary force in freshwater plankton.
Tissue‐resident memory T cells: Local guards of the thymus
Authors: Mackay Laura K. , Gebhardt Thomas
Published: August 2013

T‐cell surveillance of nonlymphoid tissues has traditionally been ascribed to recirculating memory T cells that continuously patrol the body. Extending this concept, recent evidence suggests that T cells also exist as nonmigratory memory cells that provide local immune protection in a broad range of peripheral tissues, including barrier locations such as skin and mucosa. In this issue of the European Journal of Immunology, Pircher and colleagues [Eur. J. Immunol. 2013. 43: 2295–2304] demonstrate, for the first time, the existence of such permanently tissue‐resident CD8+ memory T (TRM) cells in a primary lymphoid organ, the thymus. TRM cells in this location provide potent local immunity, which may help to preserve thymic integrity and normal T‐cell development in the face of infection with thymus‐invading pathogens.
Synthesis of Structurally Diverse Polyfunctional Pyrrolo[1,2‐a]quinolines by Sequential Iron‐Catalyzed Three‐Component Coupling and Gold‐Catalyzed Hydroarylation Reactions
Authors: Sarkar Soumen , Bera Krishnendu , Jalal Swapnadeep , Jana Umasish
Published: August 2013

A simple and efficient synthesis of complex pyrrolo[1,2‐a]quinoline derivatives was achieved through sequential reactions that involved an iron(III)‐catalyzed synthesis of N‐(2‐alkynylaryl)pyrroles and a gold(III)‐catalyzed intramolecular hydroarylation reaction. This strategy tolerated a wide range of substrates with a variety of sensitive functional groups and afforded the corresponding pyrrolo[1,2‐a]quinoline derivatives in moderate to good yields. The ease of availability of the starting materials and the generality of the reaction sequences make it a highly attractive strategy to synthesize a diverse range of pyrrolo[1,2‐a]quinoline derivatives. Moreover, a preliminary photophysical study showed that the resulting molecules exhibit good fluorescence activity.
Omics in population studies: A molecular epidemiology perspective
Authors: Bonassi Stefano , Taioli Emanuela , Vermeulen Roel
Published: August 2013

The convergence of striking developments in (bio)‐technology, increasing availability of biobanked samples, and advances in biostatistics and bio‐informatics allow an optimistic outlook for epidemiological research. In this special issue on Omics in Population Studies: A Molecular Epidemiology Perspective we explore and reflect on the potential of these new developments in both exposure science and clinical research since they provide the essential link between exposure and disease and may enable scientists to improve their understanding of disease origin and progression. As noted in this special issue, this is an exciting time for epidemiology. While cancer and other noncommunicable diseases rise in number worldwide, various new tools can be applied effectively to increase understanding of the underlying causes and potential for progression to improve their prevention and treatment. Environ. Mol. Mutagen. 54:455‐460, 2013. © 2013 Wiley Periodicals, Inc.
Mutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNA
Authors: Beardslee Renee A. , Suarez Samuel C. , Toffton Shannon M. , McCulloch Scott D.
Published: August 2013

DNA polymerase η (pol η) synthesizes past cyclobutane pyrimidine dimer and possibly 7,8‐dihydro‐8‐oxoguanine (8‐oxoG) lesions during DNA replication. Loss of pol η is associated with an increase in mutation rate, demonstrating its indispensable role in mutation suppression. It has been recently reported that β‐strand 12 (amino acids 316–324) of the little finger region correctly positions the template strand with the catalytic core of the enzyme. The authors hypothesized that modification of β‐strand 12 residues would disrupt correct enzyme–DNA alignment and alter pol η's activity and fidelity. To investigate this, the authors purified proteins containing the catalytic core of the polymerase, incorporated single amino acid changes to select β‐strand 12 residues, and evaluated DNA synthesis activity for each pol η. Lesion bypass efficiencies and replication fidelities when copying DNA‐containing cis‐syn cyclobutane thymine‐thymine dimer and 8‐oxoG lesions were determined and compared with the corresponding values for the wild‐type polymerase. The results confirm the importance of the β‐strand in polymerase function and show that fidelity is most often altered when undamaged DNA is copied. Additionally, it is shown that DNA–protein contacts distal to the active site can significantly affect the fidelity of synthesis. Environ. Mol. Mutagen. 54:638–651, 2013. © 2013 Wiley Periodicals, Inc.
Light‐limited continuous culture of Chlorella vulgaris in a Taylor vortex reactor
Authors: Kong Bo , Vigil R. Dennis
Published: August 2013

Recently, it has been demonstrated that Taylor vortices—hydrodynamic structures that arise in the annular region between two concentric cylinders when the inner cylinder rotates—can substantially improve the growth rate of algal biomass in a batch photobioreactor by inducing the flashing light effect. In order to assess the potential for using Taylor vortex flow to continuously culture algae, experiments were carried out in a continuous flow Taylor vortex algal photobioreactor using Chlorella vulgaris. Specifically, two important operating parameters were varied: the dilution rate and the inner cylinder rotation speed. For a fixed inner cylinder rotation speed, biomass productivity was independent of dilution rate. In contrast, biomass productivity was found to increase with increasing inner cylinder rotation speed for a fixed dilution rate, but this effect became less pronounced at higher rotation speeds. Overall, it is demonstrated that a continuous flow Taylor vortex algal photobioreactor can be used to produce and sustain high biomass production and carbon dioxide capture rates when operated in continuous flow mode. © 2013 American Institute of Chemical Engineers Environ Prog, 32: 884–890, 2013
Aerodynamics, climate and ventilation in long rail tunnels considering an Andean base tunnel between Argentina and Chile / Aerodynamik, Klimatisierung und Belüftung von langen Eisenbahntunneln am Beispiel eines Basistunnels in den Anden zwischen Argentinien und Chile
Authors: Flueckiger Michael , Reinke Peter
Published: August 2013

For rail tunnels which are long, heavily used and intended for high‐speed traffic, the aspects of aerodynamics, climate and ventilation may require particular design solutions. Pressure fluctuations require measures at the structures, the tunnel equipment and the rolling stock. Acceptable climate conditions are required despite heat input from the ground, rolling stock and/or technical equipment. The design of the mechanical tunnel ventilation system (TVS) is influenced by the geothermal and topographical boundary conditions as well as the occupational health and the safety requirements among other factors. In turn, the TVS influences the structural layout of the tunnel. The example of the Base Tunnel (BT) on the project Corredor Bioceanico Aconcagua (CBA) is intended to illustrate the importance of some of these aspects in a tunnelling project. The CBA is a planned rail link between Chile and Argentina with a length of about 215 km. An important component of the CBA project is a 53 km long BT (CBA‐BT) which allows the most direct crossing of the Andes with moderate gradients. The BT is the subject of on‐going conceptual studies.

Bei langen, stark genutzten und für Hochgeschwindigkeitsverkehr vorgesehenen Eisenbahntunneln erfordern Gesichtspunkte der Aerodynamik, des Tunnelklimas und der Belüftung besondere Entwurfslösungen. Druckschwankungen erfordern Maßnahmen an Bauteilen, der Tunnelausrüstung und an den Zügen. Trotz des Wärmeeintrags aus dem Gebirge, den Zügen und/oder der technischen Ausrüstung müssen annehmbare klimatische Bedingungen gewährleistet werden. Die Planung der mechanischen Tunnelbelüftungsanlage (TVS) wird von den geothermischen und topografischen Randbedingungen beeinflusst, ebenso wie von Arbeitsschutz‐ und Sicherheitsanforderungen, usw. Die Belüftungsanlage wiederum hat einen Einfluss auf die bautechnische Planung des Tunnels. Am Beispiel des Basistunnels (BT) des Projekts Corredor Bioceanico Aconcagua (CBA) soll die Bedeutung einiger dieser Aspekte in einem Tunnelprojekt aufgezeigt werden. Die CBA ist eine geplante Bahnstrecke zwischen Chile und Argentinien mit einer Länge von etwa 215 km. Ein wichtiger Bestandteil des CBA‐Projekts ist ein 53 km langer Basistunnel (CBA‐BT), der eine direkte Querung der Anden mit geringen Steigungen ermöglicht. Der Basistunnel ist Gegenstand der laufenden Konzeptstudien.
Hysteresis between coral reef calcification and the seawater aragonite saturation state
Authors: McMahon Ashly , Santos Isaac R. , Cyronak Tyler , Eyre Bradley D.
Published: August 2013

Some predictions of how ocean acidification (OA) will affect coral reefs assume a linear functional relationship between the ambient seawater aragonite saturation state (Ωa) and net ecosystem calcification (NEC). We quantified NEC in a healthy coral reef lagoon in the Great Barrier Reef during different times of the day. Our observations revealed a diel hysteresis pattern in the NEC versus Ωa relationship, with peak NEC rates occurring before the Ωa peak and relatively steady nighttime NEC in spite of variable Ωa. Net ecosystem production had stronger correlations with NEC than light, temperature, nutrients, pH, and Ωa. The observed hysteresis may represent an overlooked challenge for predicting the effects of OA on coral reefs. If widespread, the hysteresis could prevent the use of a linear extrapolation to determine critical Ωa threshold levels required to shift coral reefs from a net calcifying to a net dissolving state.
Reversing pathologically increased EEG power by acoustic coordinated reset neuromodulation
Authors: Adamchic Ilya , Toth Timea , Hauptmann Christian , Tass Peter Alexander
Published: August 2013

Acoustic Coordinated Reset (CR) neuromodulation is a patterned stimulation with tones adjusted to the patient's dominant tinnitus frequency, which aims at desynchronizing pathological neuronal synchronization. In a recent proof‐of‐concept study, CR therapy, delivered 4–6 h/day more than 12 weeks, induced a significant clinical improvement along with a significant long‐lasting decrease of pathological oscillatory power in the low frequency as well as γ band and an increase of the α power in a network of tinnitus‐related brain areas. As yet, it remains unclear whether CR shifts the brain activity toward physiological levels or whether it induces clinically beneficial, but nonetheless abnormal electroencephalographic (EEG) patterns, for example excessively decreased δ and/or γ. Here, we compared the patients' spontaneous EEG data at baseline as well as after 12 weeks of CR therapy with the spontaneous EEG of healthy controls by means of Brain Electrical Source Analysis source montage and standardized low‐resolution brain electromagnetic tomography techniques. The relationship between changes in EEG power and clinical scores was investigated using a partial least squares approach. In this way, we show that acoustic CR neuromodulation leads to a normalization of the oscillatory power in the tinnitus‐related network of brain areas, most prominently in temporal regions. A positive association was found between the changes in tinnitus severity and the normalization of δ and γ power in the temporal, parietal, and cingulate cortical regions. Our findings demonstrate a widespread CR‐induced normalization of EEG power, significantly associated with a reduction of tinnitus severity. Hum Brain Mapp 35:2099–2118, 2014. © 2013 The Authors Human Brain Mapping published by Wiley Periodicals, Inc.