bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship of Anthropometric Indices with Rate Pressure Product, Pulse Pressure and Mean Arterial Pressure Among Secondary Adolescents of 12-17 Years
Authors: Katamba Godfrey , Musasizi Abdul , Kinene Mivule Abdul , Namaganda Agnes , Muzaale Francis
Published: October 2020

Background: Anthropometric indices are highly associated with cardiovascular events. However, there correlation with hemodynamic parameters among adolescents is still wanting. Study purpose: To determine the correlation between anthropometric indices and the selected hemodynamic parameters among secondary adolescents aged 12-17 years.Methods: In this study, we present data of 485 secondary school adolescents aged 12-17 years. Height, weight, waist circumference, hip circumference and neck circumference were measured using standard protocol. Conicity index, body mass index, ponderosity index and body surface area, were computed using standard formulae. Blood pressure was measured using a digital automated blood pressure machine. The rate pressure product was determined as product of heart rate and systolic blood pressure, pulse pressure as the difference between systolic blood pressure and diastolic pressure while mean arterial pressure was the sum of diastolic pressure and pulse pressure. Comparisons of hemodynamic parameters across the anthropometric index’s categories were done using a one-way ANOVA and an unpaired t-test while correlation analysis was done using Pearson correlation coefficient at 95% confidence interval.Results: Our findings showed weak positive correlation between generally body surface area, neck circumference and conicity index with the hemodynamic parameters (systolic blood pressure, diastolic blood pressure, resting pulse rate, mean arterial pressure, rate pressure product and pulse pressure). However, the ponderosity index, body mass index and waist hip ratio showed negative weak correlations with the hemodynamic parameters. There was a significant difference in pulse pressure among the BMI categories. All parameters showed significant (p<0.05) differences across the categories of neck circumference and waist hip ratio. Generally, in multivariate regression analysis, anthropometric indices showed significant prediction of the hemodynamic parameters.Conclusion: Generally, a weak positive correlation between anthropometric indices and the hemodynamic parameters.
Role of Intravenous immunoglobulin in Non-Immunocompromised children With Severe Adenovirus Pneumonia: A Retrospective Observational Study
Authors: Fan Huifeng , Chen Chen , Xu Xuehua , Zeng Senqiang , Yin Genquan , Jiang Wenhui , Lu Gen
Published: October 2020

Background: Adenovirus pneumonia is a pulmonary infectious disease commonly occurring in children, and severe cases can lead to death and sequelae. Here, we aimed to observe the therapeutic timing and dosage of intravenous immunoglobulin(IVIg) in non-immunocompromised children with severe adenovirus pneumonia.Methods: This retrospective observational study investigated severe adenovirus pneumonia treated with IVIg in non-immunocompromised pediatric patients at a tertiary hospital in 2019. Participants were classified as early presenters (5-10 days of illness course) and later presenters (11-15 days) according to the timing of IVIg treatment. Patients’ clinical data were then analyzed in terms of different dosages of IVIg administration. Results: Among 202 patients enrolled, 128 were early presenters and 74 were later presenters during the study period. The later presenters had longer fever duration, more incidences of fungal coinfections, more demands for mechanical ventilation, and higher incidence of bronchiectasis than early presenters (P<0.05). For early presenters, no statistically significant differences in demands for advanced life support, outcomes and sequelae were observed between the two different dosage groups (P>0.05). For later presenters, shorter fever duration and lower usage of extracorporeal membrane oxygenation (ECMO) were observed in the high-dosage group than that in the low-dosage group (P<0.05). The incidence of post-infectious bronchiolitis obliterans (PIBO) and bronchiectasis was not significantly different between the two groups (P>0.05). The incidence of adverse events was 6.62% during IVIg infusion, showing no significant difference between the two groups (P>0.05).Conclusions: Early medical care and treatment with IVIg are very important to improve the prognosis of non-immunocompromised children with severe adenovirus pneumonia. For later presenters, children with severe conditions may benefit from a high IVIg dosage.
Development of Cardiorespiratory Fitness Standards for Working Memory Using Receiver Operating Curves In 15-Year-Old Adolescents
Authors: Weber Vinicius Muller Reis , Fernandes Daniel Zanardini , Volpato Leonardo Alex , Bueno Maria Raquel Oliveira , Romanzini Marcelo , Castro‐Piñero Jose , Ronque Enio Ricardo Vaz
Published: October 2020

Working memory performance is associated with better academic achievements in children and adolescents, and it is positively related to CRF. However, what level of cardiorespiratory fitness (CRF) discriminates higher working memory performance is not known. The purpose of this study was to identify thresholds of CRF linked to working memory in adolescents. Data of 141 adolescents (53.2% girls) were collected (14.9 years) from a cross-sectional study during the year 2019. CRF was assessed by the 20-m shuttle run test, and maximal oxygen uptake were calculated by Mahar´s equation. Working memory was evaluated by the Corsi blocks test and the performance was classified by percentiles. Receiver operating characteristic (ROC) curve analysis was used to identify CRF thresholds. The results of ROC analysis indicated that CRF could be used to discriminate working memory in adolescents. CRF thresholds of ³45.03 ml.kg-1.min-1for boys and ³36.63 ml.kg-1.min-1for girls were found to be indicative of “normal” performance in working memory. ConclusionCRF could discriminate low and normal working memory performance in 14-16 years old adolescents. These thresholds could allow for earlier identification and intervention of low working memory performance by the CRF.
Development and Feasibility Testing of a Play-Based Psychosocial Intervention for Reduced Patient Stress in a Paediatric Care Setting: Experiences from Pakistan
Authors: Rasheed Muneera , Bharuchi Vardah , Mughis Waliyah , Hussain Ayesha
Published: October 2020

Background: Hospitalization can be a source of great stress for children and their families. In high-income countries there are specialized staff to help children cope using different techniques including play. However, it is a major challenge in LMIC due to lack of financial and untrained human resource. The objective of study was to develop and test the feasibility and acceptance of a psychology trainee-delivered model postulated on reducing stress of hospitalized children and their caregivers. The paper describes the development of the model and feedback from the stakeholders.Methods: This feasibility study was conducted in the Paediatrics ward of a quaternary care private hospital in Pakistan. Intervention was developed using a theory of change model after surveying parental stress in relation to their child’s illness. At baseline, most parental negative emotions were identified to stem from the fear of the child relapsing, and seeing their child irritable, distressed or in pain. The package was a play-based psychosocial intervention informed by principles of Nurturing Care Framework and play therapy delivered by psychology trainees. The trainees were supervised by clinical psychologists. Children between birth to 6 years admitted in the general ward (non-intensive unit) and their parents were eligible for the intervention. Parents receiving the intervention were interviewed for their stress and feedback about the service using surveys. The trainees delivering the intervention presented their feedback as a written qualitative open-ended narrative.Results: The findings indicated the intervention when delivered on the bedside was feasible and acceptable to both parents and trainees. 45% of parents reported play intervention to be one of 3 key factors in improving their experience during hospital stay. Only 5% of parents reported feeling stressed about the child illness after the intervention. 90-96% parents felt respected, listened to, and understood by the therapists. Thematic analysis of the feedback by trainees and physicians indicated the internship to be a useful experience and a new avenue for professional life. Conclusions: The authors conclude that psychology trainees can feasibly deliver a play-based intervention under supervision for reduced stress in children and their parents during hospitalization with mutual benefits. A trainee delivered model could be a strategy to deal with shortage of trained human resource in LMICs.
Rage-txnip Axis Drives Inflammation in Alzheimer`s by Targeting aβ to Mitochondria in Microglia
Authors: Perrone Lorena , Abate Claudia , Uberti Daniela Letizia , Djelloul Mehdi , Sbai Oualid , Ieraci Alessandro
Published: October 2020

Alzheimer’s disease (AD) is the most common form of dementia characterized by progressive memory loss and cognitive decline. Although neuroinflammation and oxidative stress are well-recognized features of AD, their correlations with the early molecular events characterizing the pathology are not yet well clarified. Here we demonstrated the role of RAGE-TXNIP axis in neuroinflammation in relation to amyloid-beta (Aβ) burden in both invivo and in-vitro models. In the hippocampus of 5xFAD mice, microglial activation correlates with increased TXNIP expression, and TXNIP silencing or its pharmacological inhibition prevented the neuroinflammation in those mice. TXNIP increased expression has been found also in human subjects affected by AD and other dementia when plasma samples were analyzed, suggesting TXNIP as a putative biomarker of neurodegeneration and cognitive decline. To better elucidate whether a mechanistic link between RAGE-TXNIP axis and AD exist, we investigated how TXNIP is involved in Aβ intracellular trafficking downstream RAGE. Indeed, TXNIP is an α-arrestin protein involved in endocytosis. We found TXNIP associated to RAGE and Aβ. RAGE-TXNIP axis was required for targeting Aβ into mitochondria, as shown in primed primary microglia exposed to Aβ dimers. Silencing of TXNIP or inhibition of RAGE activation reduced Aβ transport from the cellular surface to mitochondria. Detrimental effect of Aβ in mitochondria has been also confirmed by evaluating increased mitochondrial- and intracellular- oxidative stress. When RAGE-TXNIP axis is down-regulated, mitochondrial functionality was restored and Aβ toxicity was mitigated. Furthermore, Aβ transport into mitochondria and subsequent mitochondrial dysfunction drove inflammation in microglia cells via NLRP3 inflammasome activation, and down-regulation of RAGE-TXNIP axis was able to efficiently mitigate Aβ proinflammatory effect. Overall this data suggest RAGE-TXNIP axis is required for NLRP3 inflammasome activation induced by Aβ in microglia.Our work shed light on novel mechanism of action of RAGE-TXNIP axis in microglia, which is intertwined with Aβ and ultimately causes inflammation, suggesting TXNIP as a druggable target to be better deepened for AD.
A comparative study of oblique lumbar interbody fusion combined posterior percutaneous internal fixation and the anterior-posterior combined surgery in the treatment of single-segment lumbar tuberculosis
Authors: Liu Zuozhong , Huang Lili , Yuan Jiaqin , Shao Gaohai , Li Bo , Deng Zhongliang
Published: October 2020

Objectives:To study the clinical effect of OLIF channel combined with posterior percutaneous pedicle screw fixation in the treatment of single-segment lumbar tuberculosis.Methods:Using a retrospective controlled study, patients who were diagnosed with single-segment lumbar tuberculosis were divided into the minimal invasive group(the anterior debridement and fusion by OLIF technique combined percutaneous pedicle screw group) and the open group(the anterior-posterior combined surgery group) according to different surgical methods from July 2016 to October 2018,then the surgical-related parameters and surgical effects of the two groups of patients were compared.Results:The minimal invasive group was superior to the open group in operation time, abdominal incision length,intraoperative blood loss,postoperative drainage, and CPK,the differences were statistically significant (P<0.05);The VAS scores of low back pain after 3 days,3mounths and last follow-up of surgery was significantly lower than before surgery in both goups (P<0.05), which in the minimal invasive group was significantly lower than those in the open group at 3days after surgery （P<0.05）,but no significance in other time point(P＞0.05).The ODI index, ESR, CRP before operation, 3 months and the last follow-up after surgery were not statistically different between two groups(P＞0.05),and significant difference in the group(P<0.05). Postoperative lumbar lordosis increased significantly in the two groups after operation, and there was no statistical difference between the groups at each time point(P＞0.05).Conclusion:The clinical effect of OLIF channel combined with posterior percutaneous pedicle screw fixation in the treatment of single-segment lumbar tuberculosis is not different from the anterior-posterior combined surgery, but the trauma is smaller and the recovery is faster in the former, which has certain advantages in clinic.
Capital Flight, Hard Mineral Resources Exports and Political Governance Crisis in the Central African Republic: How Far We have Learned?
Authors: Kossele Thales Pacific Yapatake
Published: October 2020

The Autoregressive Distributed Lag (ARDL) approach to cointegration is applied to examine the role of political governance crisis in the relationship between hard mineral resources exports particularly diamond, and gold and Capital flight in the Central African Republic over the period of 1978-2010. The results of short-run show that official development assistance, gross national expenditures have a negative and significant impact on capital flight while the interaction of political governance crisis and hard mineral resources, GDP per capita have a positive and significant effect with capital flight. Moreover, governance crisis, exports of hard mineral resources has a negative and insignificant impact on capital flight. The results of the long run show a negative and significant effect on governance crisis, official development assistance and gross of national expenditures. The interaction term between hard mineral resources and GDP growth have a positive and significant effect on capital flight. However, export of hard mineral resources exhibits a positive but insignificant effect on capital flight. Without strong action to stop and promote political governance stability and the implementation of appropriate reforms at institutional level in CAR’s hard minerals resources sector, success in the fight against capital flight is unlikely.
Radioembolisation with Holmium-166 Polylactic Acid Microspheres: Distribution of Residual Activity and Flow Dynamics During Planning and Treatment Procedures
Authors: Freesmeyer Martin , Seifert Philipp , Gühne Falk , Kühnel Christian , Drescher Robert
Published: October 2020

Purpose:To evaluate the application dynamics and residual Ho-166 activity during and after transarterial radioembolisation planning and treatment procedures, and to assess the distribution and predilection sites of residual activity in the proprietary delivery set and microcatheter.Methods:16 planning (Holmium Scout Dose, HSD) and 12 therapeutic radioembolisation (RE) procedures were performed with poly-L-lactic acid (PLLA) microspheres loaded with Ho-166. The amount and distribution of residual activity was assessed by dose calibrator measurements and SPECT imaging. For 8 HSD and 5 RE procedures, the dynamic of the microsphere flow were assessed. For HSD procedures, different injection methods were evaluated. Results:The mean residual activities for HSD and RE procedures were 20.5 +/-9.7% (range 7.2-44.1%) and 4.8 +/-1.2% (range 3.5-6.9%), respectively. HSD residual activity could be decreased significantly with injections methods similar to RE procedures, from 31.2 +/-9.6% to 17.7 +/-6.9% and 15.0 +/-6.0% (p=0.005). Main predilection sites of residual microspheres were the 3-way stopcock (HSD) and the outflow needle connector (RE). During RE procedures, >80% of the injected activity is transferred during the first three injection cycles.Conclusion: After treatment procedures with PLLA microspheres, mean residual activity in the delivery set is reproducibly low and between reported values for glass and resin microspheres. The majority of microspheres is transferred to the patient during the second and third injection cycle. An estimated residual waste of 3%-4% may be included in the treatment activity calculation. For planning procedures, a modified injection technique should be used to avoid high residual activities.
Prognostic Significance of Preoperative Serum Uric Acid-to-Lymphocyte Ratio in Hepatocellular Carcinoma Patients Undergoing Postoperative Transarterial Chemoembolization: A Propensity Score-Matching Study
Authors: Hu Shan-shan , Liu Li-heng , Tang Li-ping
Published: October 2020

BackgroundHepatocellular carcinoma (HCC) accounts for 85%–90% of primary liver cancers and is the seventh most common cancer worldwide. The purpose of this study is to determine an innovative and effective clinical index for prognosis prediction in HCC patients. MethodsA total of 132 patients with HCC were included in this research. A cohort of 72 cases was obtained through propensity score-matching. Patients were divided into high- and low-level groups based on the ratio of preoperative uric acid levels to lymphocytes. The differences in clinical characteristics and survival indicators were compared between the two groups.ResultsThere was a statistical difference between uric acid-to-lymphocyte ratio (ULR) level and tumor size (P < 0.01). Multivariate analysis showed that ULR (P = 0.03) and tumor size (P = 0.03) were independent risk factors for overall survival (OS). ULR (P < 0.04) and diabetes (P = 0.04) were independent risk factors for progression-free survival (PFS) in HCC patients. Further survival analysis of the entire cohort and propensity score-matching cohort showed that the OS and PFS in the high-level ULR group were significantly shorter than those in the low-level ULR group (log-rank P < 0.001). Conclusion This study demonstrated that ULR is a marker of poor prognosis in postoperative HCC patients, while high ULR levels predicted shorter OS and PFS.
Performance of Plasma Amyloid β, Total Tau and Neurofilament Light Chain Levels for Alzheimer’s Disease Identification
Authors: Jiao Bin , Liu Hui , Guo Lina , Liao Xinxin , Zhou Yafang , Weng Ling , Xiao Xuewen , Zhou Lu , Wang Xin , Jiang Yaling , Yang Qijie , Zhu Yuan , Zhou Lin , Zhang Weiwei , Wang Junling , Yan Xinxiang , Tang Beisha , Shen Lu
Published: October 2020

BackgroundRobust studies have focused on blood-based biomarkers for diagnosis of Alzheimer’s disease (AD), while the results were still controversary and failed verified in different cohorts. The aim of this study was to detect the levels of plasma amyloid β (Aβ), total tau (t-tau), and neurofilament light chain (NfL) in patients with AD and cognitive normal (CN) subjects, and clarify their associations with Aβ, t-tau, and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) as well as brain amyloid PET, and calculate the diagnostic efficiency of these characteristics regarding AD.Methods Plasma Aβ42, Aβ40, t-tau and NfL levels were detected by single-molecule array (Simoa) in 379 AD patients and 153 CN subjects. Additionally, lumbar puncture was conducted in 125 AD patients to detect Aβ42, Aβ40, t-tau, and p-tau levels. Brain amyloid PET was performed in 52 AD patients to identify brain amyloid deposition levels. Correlation analysis were performed between plasma biomarkers and typical biomarkers of AD, including CSF core biomarkers and amyloid PET burden. Finally, the diagnostic value of plasma biomarkers was further assessed by receiver operating characteristic (ROC) curve.ResultsCompared with the CN group, plasma Aβ42 and Aβ42/Aβ40 levels were significantly lower in AD patients, while Aβ40, t-tau and NfL levels were higher in AD patients. Among the AD patients, plasma Aβ42 was positively correlated with CSF Aβ42 (r = 0.195, p = 0.03) and Aβ42/Aβ40 (r = 0.208, p = 0.04). Moreover, plasma NfL was positively correlated with age, disease course and severity. The diagnostic model with combined plasma Aβ42, t-tau, and NfL levels controlled for age and APOE genotype showed the best performance to identify AD (area under the curve (AUC) = 0.88, sensitivity = 82.84%, specificity = 81.69%, cutoff value = 0.64).ConclusionsTrends revealed by core biomarkers were generally consistent in AD patients’ plasma and CSF. Combining plasma biomarkers can provide comparatively high AD diagnostic performance.
Mathematical and Statistical Study on Covid19- SIR Model
Authors: Datta Jaydip
Published: October 2020

In this combinatorial study let us try to simulate the four cases starting from viral spreading kinetics , Gaussian distribution of the infectious disease , modelling of remdesivir on the basis of molecular bonding approach and finally the most important mortality statistics like infection fatality ratio ( IFR ) with the distribution of age of the patient through sigmoid regression method .It is an alternative approach to susceptibility – infectivity – recovery ( SIR ) model .
Structure of Mycobacterium tuberculosis Phe-tRNA synthetase reveals ligand binding and two-stage tRNA recognition
Authors: Michalska Karolina , Jedrzejczak Robert , Wower Jacek , Chang Changsoo , Baragaña Beatriz , Gilbert Ian H. , Forte Barbara , Joachimiak Andrzej
Published: October 2020

Tuberculosis, caused by Mycobacterium tuberculosis, responsible for ~1.5 million fatalities in 2018, is the deadliest infectious disease. Global spread of multidrug resistant TB is a public health threat. Aminoacyl-tRNA synthetases are plausible candidates as potential targets because they play pivotal roles in translating the DNA code into protein sequence by attaching specific amino acid to their cognate tRNAs. One of the best characterized synthetases is specific for L-Phe and tRNAPhe. Here we report structures of M. tuberculosis Phe-tRNA synthetase complexed with precursor tRNA and either phenylalanine or a phenylalanine adenylate analog, 5′-O-(N-phenylalanyl)sulfamoyl-adenosine. Crystallographic models for the first time reveal two modes of interaction with tRNA: an initial recognition via the anticodon loop and stem only and productive binding with interaction of the 3’ end of tRNAPhe with the adenylate site. We biochemically characterize the enzyme and provide the highest resolution, most complete view of the Phe-tRNA synthetase/tRNAPhe system to date.
PENGEMBANGAN MODUL BIOLOGI TERINTEGRASI NILAI ISLAM PADA MATERI SISTEM REPRODUKSI MANUSIA
Authors: Maulidatul Ana , Ismail Ismail , Mukhlishoh Siti
Published: October 2020

Pengembangan modul Biologi bernilai Islam ini bertujuan untuk menghasilkan sumber belajar Biologi dilengkapi dengan nilai Islam. Penelitian ini merupakan sarana dalam rangka membangun landasan bagi  perkembangan potensi peserta didik agar menjadi manusia yang beriman dan bertakwa kepada Tuhan Yang Maha Esa, berakhlak mulia dan berkepribadian luhur. Tujuan adanya modul adalah membuka kesempatan bagi peserta didik untuk belajar menurut kecepatan individu, karena dianggap bahwa peserta didik tidak akan mencapai hasil yang sama dalam waktu yang sama dan tidak sedia mempelajari sesuatu pada waktu yang sama. Penelitian ini merupakan penelitian pengembangan dengan memodifikasi pola 4D (Define, Design, Develop and Disseminate). Tahap define guna menyiapkan kebutuhan dalam pengembangan modul. Tahap selanjutnya adalah design guna merancang modul yang dikembangkan. Pengembangan dilanjutkan dengan tahap develop yang mana pada tahap ini ada 3 macam jenis penilaian yang dilakukan untuk mengetahui tingkat kelayakan modul yang dikembangkan. Penelitian ini telah menghasilkan prototype modul Biologi bernilai Islam dengan kualitas layak dan siap untuk diuji cobakan pada tahap berikutnya, yaitu disseminate. Modul yang dikembangkan masuk dalam kategori layak untuk digunakan karena, persentase rata-rata penilaian dari ahli materi 81.9%, untuk ahli media 83.3% dan guru biologi 82%. Hasil untuk presentase tanggapan peserta didik pada uji lapangan terbatas adalah 78% dengan kriteria layak, dan tanggapan peserta didik pada uji lapangan luas sebesar 80,64% dengan kriteria layak.
EFEKTIVITAS MODEL PEMBELAJARAN STAY AND STRAY DENGAN MEDIA FLASHCARD TERHADAP HASIL BELAJAR PESERTA DIDIK PADA MATERI SISTEM PERNAPASAN DI KELAS XI IPA SMA NEGERI 5 SEMARANG TAHUN AJARAN 2016/2017
Authors: Setiawati Diah , Miswari Miswari , Hidayat Saifullah
Published: October 2020

Penelitian ini dilatarbelakangi oleh kurangnya perhatian peserta didik dalam proses pembelajaran biologi. Kreativitas guru dalam mengembangkan model pembelajaran dan media pembelajaran saat proses pembelajaran diperlukan untuk meningkatkan minat, keaktifan dan hasil belajar peserta didik. Penelitian ini bertujuan untuk mengetahui efektivitas model pembelajaran Stay and Stray dengan media Flashcard terhadap hasil belajar peserta didik pada materi sistem pernapasan di kelas XI IPA SMA Negeri 5 Semarang. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksperimen. Desain penelitian ini menggunakan Quasi eksperimen Pre-test and Post-test group design. Teknik pengambilan sampel dilakukan dengan teknik simple random sampling. Pengumpulan data dilakukan pada kelas XI IPA 4 dan XI IPA 8 dengan menggunakan 2 metode, yaitu metode tes dan metode dokumentasi. Hasil penelitian menunjukkan nilai rata-rata posttest kelas eksperimen adalah 93,5 dan kelas kontrol adalah 79,25. Data yang diperoleh adalahthitung = 8,699 dan ttabel= 1,669, karena thitung>ttabel maka Ho ditolak dan Ha diterima. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa model pembelajaran Stay and Stray dengan media Flashcard pada materi sistem pernapasan terbukti efektif terhadap hasil belajar siswa kelas XI IPA SMA Negeri 5 Semarang.
PENGEMBANGAN MEDIA PEMBELAJARAN SCRAPBOOK UNTUK MENINGKATKAN MOTIVASI BELAJAR PADA MATERI VERTEBRATA DI KELAS X MA NU HASYIM ASY’ARI 3 KUDUS
Authors: Fauziyah Shofia Lana
Published: October 2020

Ketidakpahaman siswa mengenai materi vertebrata, menyebabkan mereka menganggap bahwa materi Biologi sulit sehingga menyebabkan motivasi belajar menjadi menurun. Salah satu alternatif untuk mengatasi penurunan motivasi belajar yaitu dengan menggunakan media pembelajaran scrapbook. Hasil penelitian menunjukkan bahwa penilaian kualitas scrapbook oleh ahli materi memperoleh persentase sebesar 91%, penilaian oleh ahli media sebesar 84%, penilaian oleh guru Biologi sebesar 94% dan tanggapan siswa sebesar 87%. Hasil motivasi belajar awal diperoleh skor 56% dengan kategori sedang/ cukup termotivasi, sedangkan motivasi belajar akhir diperoleh skor 79% dengan kategori tinggi/ termotivasi. Berdasarkan pengukuran motivasi belajar awal dan motivasi belajar akhir, dapat disimpulkan bahwa pengembangan media pembelajaran scrapbook dapat meningkatkan motivasi belajar siswa sebesar 23% dengan gain score sebesar 0.52 termasuk dalam kategori sedang Pada uji beda dengan uji t diperoleh thitung sebesar 16.449 dan ttabel sebesar 2.093, karena thitung > ttabel maka terdapat perbedaan yang signifikan antara sebelum dan sesudah menggunakan media pembelajaran scrapbook. Media pembelajaran scrapbook secara keseluruhan memperoleh penilaian dalam kategori sangat baik, sehingga sangat layak digunakan sebagai media pembelajaran dan pengembangan media pembelajaran scrapbook pada materi vertebrata dapat meningkatkan motivasi belajar peserta didik kelas X.
A novel polyethersulfone/modified activated carbon fiber composite membrane: potential for removal micropollutants from water under the electric field
Authors: Wang Cunshi , Fu Ting , Zhu Qiuzi , Yang Ruihong , Cao Yanyan , Zhu Jianzhong
Published: October 2020

This study aimed to develop a novel composite membrane based on polyethersulfone (PES) and modified activated carbon fibers (ACFs) to remove of sulfamethoxazole (SMZ) from water. The modification of ACFs was conducted by using acid, Fe, and Mn and was confirmed by Fourier transform infrared spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDS), and water contact angle measurement. Later on, the composite membranes were prepared using PES (9 wt%), N-N-dimethylacetamide (DMAc) (75 wt%), polyethylene pyrrolidone (PVP) (5 wt%), anhydrous lithium chloride (LiCl) (1 wt%), and various types of modified ACFs (0.8 wt%) as additives. It was found that the contact angle of the membrane decreased by more than 20°, and the zeta potential decreased by more than 10 mV. ACF modified by Fe was used as an admixture, membrane obtained the high comprehensive performance. Especially bovine serum albumin (BSA) rejection rate and flux recovery ratio (FRR) reached 98.8% and 98.4%, respectively. And the removal rates of SMZ increased by 24.6% under the electric field. The degradation products were detected by high-performance liquid chromatography/mass spectrometry (HPLC/MS). Based on this result, the possible degradation pathways of SMZ are proposed.
Method for attachment of TiO2 using design of experiments: application to the photocatalysis of a model pollutant methylene blue dye
Authors: Aıt Atmane Abdenour , Bourouına-Bacha Saliha
Published: October 2020

The preparation of titanium dioxide (TiO2) supported on a glass plate by heat attachment method is presented. With the use of response surface methodology based on a central composite design we investigated the influence of the experiment parameters of the TiO2 deposition (temperature of calcination (T), time of calcination (ts) and the concentration of TiO2 ((TiO2))) on photocatalytic activity of the semiconductor for the degradation of a model pollutant: methylene blue. The analysis of variance results showed that the selected quadratic model with interaction (R2 = 0.9802) was statistically significant. The experimental results showed that the degradation quantity of methylene blue increased when the ts value increased and T decreased. We have evaluated the photocatalytic activity of this supported catalyst (TiO2-GP) with a laboratory reactor under natural condition; the maximum removal (96.03%) was obtained at ts = 331 min, T = 559 °C and (TiO2) = 2.38 g/l. The method of desirability function was used to obtain the best combination of factor settings for achieving the maximum of degradation quantity ((TiO2) = 2.6 (g/l), T = 600 (°C) and ts = 240 (min)). The additional tests on the catalyst plates confirmed that the deposits keep their catalytic activity for several cycles of use.
Genetic Interactions Effects of Cardiovascular Disorder Using Computational Models: A Review
Authors: Priya Sridharan , Manavalan Radha K.
Published: October 2020

Background:

The diseases in the heart and blood vessels such as heart attack, Coronary
Artery Disease, Myocardial Infarction (MI), High Blood Pressure, and Obesity, are generally referred
to as Cardiovascular Diseases (CVD). The risk factors of CVD include gender, age, cholesterol/
LDL, family history, hypertension, smoking, and genetic and environmental factors. Genome-
Wide Association Studies (GWAS) focus on identifying the genetic interactions and genetic architectures
of CVD.

Objective:

Genetic interactions or Epistasis infer the interactions between two or more genes where
one gene masks the traits of another gene and increases the susceptibility of CVD. To identify the
Epistasis relationship through biological or laboratory methods needs an enormous workforce and
more cost. Hence, this paper presents the review of various statistical and Machine learning approaches
so far proposed to detect genetic interaction effects for the identification of various Cardiovascular
diseases such as Coronary Artery Disease (CAD), MI, Hypertension, HDL and Lipid
phenotypes data, and Body Mass Index dataset.

Conclusion:

This study reveals that various computational models identified the candidate genes
such as AGT, PAI-1, ACE, PTPN22, MTHR, FAM107B, ZNF107, PON1, PON2, GTF2E1, ADGRB3,
and FTO, which play a major role in genetic interactions for the causes of CVDs. The benefits,
limitations, and issues of the various computational techniques for the evolution of epistasis responsible
for cardiovascular diseases are exhibited.
Molecular Processes Involved in Pancreatic Cancer and Therapeutics
Authors: Makar Subhajit , Ghosh Abhrajyoti , Divya  , Shivhare Shalini , Kumar Ashok , Singh Sushil K.
Published: October 2020

Despite advances in the development of cytotoxic and targeted therapies, pancreatic
adenocarcinoma (PAC) remains a significant cause of cancer mortality worldwide. It is
also difficult to detect it at an early stage due to a number of factors. Most of the patients are
present with locally advanced or metastatic disease, which precludes curative resection. In
the absence of effective screening methods, considerable efforts have been made to identify
better systemic treatments during the past decade. This review describes the recent advances
in molecular mechanisms involved in pancreatic cancer initiation, progression, and metastasis.
Additionally, the importance of deregulated cellular signaling pathways and various cellular
proteins as potential targets for developing novel therapeutic strategies against incurable
forms of pancreatic cancer is reported. The emphasis is on the critical functions associated
with growth factors and their receptors viz. c-MET/HGF, CTHRC1, TGF-β, JAK-STAT, cyclooxygenase
pathway, WNT, CCK, MAPK-RAS-RAF, PI3K-AKT, Notch, src, IGF-1R,
CDK2NA and chromatin regulation for the sustained growth, survival, and metastasis of
pancreatic cancer cells. It also includes various therapeutic strategies viz. immunotherapy,
surgical therapy, radiation therapy and chemotherapy.
Interactive Web-Based Resource for Annotation of Genetic Variants Causing Hereditary Angioedema (HADA): Database Development, Implementation, and Validation (Preprint)
Authors: Mendoza-Alvarez Alejandro , Muñoz-Barrera Adrián , Rubio-Rodríguez Luis Alberto , Marcelino-Rodriguez Itahisa , Corrales Almudena , Iñigo-Campos Antonio , Callero Ariel , Perez-Rodriguez Eva , Garcia-Robaina Jose Carlos , González-Montelongo Rafaela , Lorenzo-Salazar Jose Miguel , Flores Carlos
Published: October 2020

BACKGROUND

Hereditary angioedema is a rare genetic condition caused by C1 esterase inhibitor deficiency, dysfunction, or kinin cascade dysregulation, leading to an increased bradykinin plasma concentration. Hereditary angioedema is a poorly recognized clinical entity and is very often misdiagnosed as a histaminergic angioedema. Despite its genetic nature, first-line genetic screening is not integrated in routine diagnosis. Consequently, a delay in the diagnosis, and inaccurate or incomplete diagnosis and treatment of hereditary angioedema are common.

OBJECTIVE

In agreement with recent recommendations from the International Consensus on the Use of Genetics in the Management of Hereditary Angioedema, to facilitate the clinical diagnosis and adapt it to the paradigm of precision medicine and next-generation sequencing–based genetic tests, we aimed to develop a genetic annotation tool, termed Hereditary Angioedema Database Annotation (HADA).

METHODS

HADA is built on top of a database of known variants affecting function, including precomputed pathogenic assessment of each variant and a ranked classification according to the current guidelines from the American College of Medical Genetics and Genomics.

RESULTS

HADA is provided as a freely accessible, user-friendly web-based interface with versatility for the entry of genetic information. The underlying database can also be incorporated into automated command-line stand-alone annotation tools.

CONCLUSIONS

HADA can achieve the rapid detection of variants affecting function for different hereditary angioedema types, and further integrates useful information to reduce the diagnosis odyssey and improve its delay.
Measurement in an on-demand virtual mental health system: a review and viewpoint (Preprint)
Authors: Kunkle Sarah , Naslund John A , Hunt Justin , Udall Dana , Hayes Erica , Ξ Watson , Mithal Vasudha
Published: October 2020

UNSTRUCTURED

Mental health is a growing public health priority in the United States and globally. Measurement-based care (MBC) has been shown to improve outcomes in clinical care, yet there are significant challenges to implementation. New technologies offer opportunities to address these obstacles and to measure new and existing constructs at a scale that was previously not possible. This paper aims to summarize existing literature on MBC, focusing on mental health and digital health. Specifically, we describe a case example called Ginger, a novel on-demand virtual system for delivering mental health services, and demonstrate how this platform aligns with core principles of MBC in mental health based on existing frameworks and findings from the literature. Additionally, we integrate feedback from multidisciplinary stakeholders (clinical practitioners, data science, product development and management, and research) to develop a perspective on key tenets of measurement in this system. To navigate the challenges of translating traditional measurement tools into new technologies in addition to developing new measurements, this multidisciplinary perspective is required. Ultimately, this will enhance our understanding of mental health and ability to develop interventions to improve outcomes.
Ho Chi Minh's Ideology on National Unity in Vietnam's Revolution
Authors: Dieu Tran Thi
Published: October 2020

For any country in the stage of development, unity is always considered as palpable pilar for a stable and sustainable goal of welfare. This study focuses on the case of Vietnam by analysing Ho Chi Minh’s ideology. He is the initiator and builder of Vietnamese nation known as the ideology on great unity which continues to be expressed from theory to practice. Great national unity is both the goal and the top task of the revolution which may be seen thoroughly in all paths, guidelines and policies of the Party during the Party Congresses. This article further discusses the basis for the formulation of the national unity based on Ho Chi Minh’s ideology, explain why Ho Chi Minh can solve the national-class relationship, and draw out the implication for Vietnam in the stage of current development.
The soundscape of Anthropocene
Authors: Talianni Katerina
Published: October 2020

Recently, much attention has been paid to the many different forms of collaborative or participatory practice both within, and out with the academy; from practice-based research to theoretical contributions and artistic experimentations. In terms of acoustemology as described by Steven Feld, the creative processes of collaborative soundscaping practices, developed as dialogic editing, produce theories of sound as knowledge production. Within this trend of doing anthropology in sound, sound art works aim to reconnect communities to the environment and indicate the emergence and presence of an ecological and aesthetic co-evolution. Such projects, in fostering interdisciplinary approaches, allow the development of hybrid types of knowledge through dialogic exchanges, and engage multiple agents by developing audile techniques. They also raise interesting questions within collaborative and interdisciplinary creative practice, in relation to the critical examination of the instrumentality of collaboration. By focusing on field recordings and soundscape compositions this paper discusses ecological sound art works that use collaborative creativity, new technologies, and phenomenological listening, to produce dialogic and collaborative forms of epistemic and material equity. These sound art works are the result of complex expressions of creative processes that involve multiple agents, while successfully voice their authorial presence. The interdisciplinary, collaborative and open-ended nature of these projects brings forward the social and political dimension of sound and listening, which could figure in more collaborative forms of knowledge production and inspire climate action.
Editorial
Authors: Lycouris Sophia , Panourgia Eleni Ira , Talianni Katerina , Walker Jack
Published: October 2020

Over the past two decades, collaboration has emerged as a keyword and an important methodological and ethical concern in various disciplines, which has nurtured interdisciplinary approaches that often encompass innovative processes of knowledge production. In sonic practice, trends such as participatory art, the workshop turn, and ideas of Do-It-With-Others contributed to the emergence of creative processes that manifest within the sphere of inter-human relations through participation and collaboration. Such processes can operate beyond the institutional space, or classic studio and gallery settings, by engaging directly with the social realm; blurring the lines between art, performance and our lived social, political, economic, technological and environmental realities. How are interdisciplinary practices, methodologies and vocabularies shaping the way sound and music works are created and experienced? How does this search for knowledge change sonic practice? The second issue of Airea Journal explores these questions by presenting practice-based and theoretical contributions of collaborative interdisciplinary creative processes in sound. This special focus on sound is addressed from multiple perspectives in relation to compositional, audiovisual, social, political, environmental, participatory and performative standpoints. This is a move that pays attention to and interrogates the aesthetics, methodologies and politics of interdisciplinary sonic practices. The sound arts often involve more than one disciplines and in order to study and comprehend them, an interdisciplinary approach is demanded. Many sound artworks are more than just (about) sound or sounds. Consequently, no single discipline is able to fully encompass how sound as affective and vibrant matter can be both reflexive and constitutive of social, cultural, political, religious, ethical, and perhaps even biological or cognitive developments. Sound can be investigated from almost any angle, and the articles in the present issue include numerous disciplines and subjects.
Gobernanza y fondos de pensiones. Análisis de mejores prácticas internacionales
Authors: Avilés Ochoa Ezequiel , Torres López Luis Roberto
Published: October 2020

El objetivo de este texto es presentar un análisis de las mejores prácticas de gobernanza de fondos de pensiones en el contexto internacional, y estructurar un marco referencial para la orientación de la política pública de los institutos de pensiones. Por un lado, realiza una revisión teórica de la literatura científica sobre los paradigmas de la gobernanza; y por otro, ofrece resultados que muestran que las mejores prácticas incluyen: transparencia, toma de decisiones políticas, prevención del riesgo, seguros, manejo del modelo fiduciario, controles de inversión, regulación, supervisión y restricción a intervenciones discrecionales mediante ordenamientos legales
Michael T. Klare, All Hell Breaking Loose. The Pentagon’s Perspective on Climate Change
Authors: Sánchez Méndez Paola Montserrat
Published: October 2020

En décadas recientes, las transformaciones más importantes a nivel global han estado atravesadas por un ciclo de crisis socio-ecológicas que han complejizado los análisis de las ciencias sociales, debido a su devastadora notoriedad y gravedad en cada vez más territorios.
De los años 20 AL 2.0: Desplazamientos alrededor de la lactancia y de la maternidad en Brasil
Authors: De Figueiredo Souza Ana Luiza
Published: October 2020

Alineadas con el proyecto republicano para reducir la mortalidad infantil y reconfigurar el lugar social de las mujeres, revistas femeninas como la Vida Doméstica (1920-1963) se convirtieron en vehículos donde los médicos higienistas aconsejaban a las madres sobre el cuidado infantil en las primeras décadas del siglo XX en Brasil. Al identificar continuidades y rupturas entre el enfoque materno de las columnas y publicaciones de Cousas Úteis (Cosas Útiles, 1921) y Medicina doméstica (1926) y posteos en el perfil personal y en la página profesional de dos madres contemporáneas, en Facebook, se demuestra que la maternidad se construyó alrededor de los ideales del instinto materno, el amor y la devoción, y que hoy, a través de sus narrativas personales, las mujeres buscan retratar los impasses de la vivencia materna, evidenciando los aspectos idealizadores y moralizantes que la marcaron.

 
Desplazamiento interrumpido: reescritura de la tradición y el espacio en la literatura de viajes de Martín Caparrós
Authors: Juárez Vázquez Gerardo
Published: October 2020

El artículo analiza las bases estéticas y políticas que conforman la tradición de la literatura de viajes. Estudia, asimismo, la relación del género con el colonialismo y su función como dispositivo colonial. Una vez establecido este marco, el artículo se centra en el proyecto narrativo de Martín Caparrós (conformado por Una luna, Contra el cambio y El hambre) y en las estrategias mediante las cuales éste interviene la tradición del género.
Wilson Cano, interpreter of regional and urban issues in Brazil
Authors: Brandão Carlos Antônio , Oliveira Fábio Lucas Pimentel de , Guimarães Neto Leonardo , Santos Valdeci Monteiro dos
Published: October 2020

This article is a tribute by representatives from four generations of researchers, who were taught and supervised by Professor Wilson Cano (1937-2020). The text follows an academic trajectory that bequeathed a fundamental contribution towards the understanding of regional and urban issues in Brazil. The aim is to highlight the most distinctive aspects of his studies, based on a dynamic-historical and contradictory conception of capitalist development and the regional and urban repercussions that have resulted from such a process. Under the aegis of the historical-structural method, we identify, within his analyses, a rigorous investigation into the formation of regional complexes, of the movements of spatial concentration and deconcentration driven by industrialization, and of the determinations of the land issue for urbanization. He sought to situate the regional and urban debate within the context of the need to push forward a national development project, without which, the regions and cities of Brazil would become subjugated to the determinants of neoliberalism and to the loss of the nation’s sovereignty.