bluuebunny/crossref_metadata_2025 huggingface dataset:
Hearing Loss: Applying the Social-Ecological Model for Change
Authors: Hinson-Enslin Amanda M. , McClintock Heather F.
Published: August 2022

Introduction: The proportion of Ohioans experiencing deafness or serious difficulty hearing is higher than national estimates and is increasing over time.
Purpose: The purpose of this study is to describe the burden, risk factors, comorbidities, and financial implications of hearing loss in Ohio as well as discuss approaches to reduce the burden of hearing loss in Ohio applying the Social-Ecological Model
Methods: A narrative review was completed to summarize peer-reviewed literature on hearing loss in Ohio. The Social-Ecological Model was applied to identify approaches to reduce the burden of hearing loss in Ohio.
Results: The burden of hearing loss on health and economic well-being is substantial in Ohio. While initiatives have sought to reduce costs and increase access, barriers continue to persist impeding people’s ability to obtain needed services in Ohio. Approaches were identified on all levels of the Social-Ecological Model to address the burden of hearing loss in Ohio such as creating interventions for prevention, improving access to hearing tests and hearing aids, and changing policies that expand insurance coverage for hearing aids.
Conclusion: There is a critical need for public health-initiated programs and policies that reduce barriers and increase access to hearing related services that can be implemented on all levels of the Social-Ecological Model.
Perceptions of How Integrated Care Impacts Treatment in Rural Settings
Authors: Graham Dawn , Nandyal Samantha , Ayad Salonas
Published: August 2022

Background: In light of the changing face of health care, it is important that practitioners and researchers begin to think strategically regarding comprehensive and accessible care. The purpose of this research study is to provide a deeper understanding of change among health care providers who work on multidisciplinary teams and the impact on patient outcomes.
Methods: This research was designed as an exploratory phenomenological research study. The experience of interest was how providers described changes in care when working in an integrated care context. Eight semistructured in-depth interviews were conducted with physicians, nurse practitioners, social workers, and psychologists from locations in Southern Ohio, Central Maine, and Eastern Tennessee. Data were analyzed using qualitative coding to find patterns with and across participants associated with their perceptions of health integration.
Results: Final developed themes described provider perceptions of working in an integrated care environment, and included access to care, interprofessional education, communication between providers.
Conclusion: Through interviews and a review of the literature, we have found that as integrated care is employed throughout the country, patients have better health outcomes and providers experience efficient and effective work environments. Providers have adapted to the changing environment of integrative medicine; through this study we see that these changes have been for the benefit of the patients. Patients who disproportionately suffer from a lack of health care resources, such as those in rural areas, may benefit greatly from an integrated care model.
Patient Access to Care: In-Network and Out-of-Network Utilization of Services
Authors: Lanese Bethany G. , Alrubaie Nora
Published: August 2022

Background: Access to health care is impacted by several key factors such as urbanization, insurance coverage, availability of health care facilities, specialists, and equipment. For an in-depth understanding of Portage County area residents' health care utilization location choices, a study was conducted to identify the main factors and assess health care outmigration.
Methods: A total of 125 292 patients were identified using 2019 administrative health data from University Hospitals Portage Medical Center in Portage County, Ohio. A descriptive analysis, t test, and chi-square tests were used to examine 3 primary outcomes: (1) patients’ demographics (age, gender, insurance, etc.), (2) time and distance patients are willing to travel for care, and (3) health services demand that is causing outmigration.
Results: An analysis of 119 034 patients showed 66% of patients stayed in network and 34% went out of network. In-network participants had an average travel time of 30 minutes [95% CI, 29.5 to 29.8] and an average distance of 19.4 miles [95% CI, 15.9 to 16.1]. Conversely, out-of-network participants averaged 43 minutes [95% CI, 43.1 to 43.5] and 30.8 miles [95% CI, 30.4 to 30.8]. Outmigration was mainly influenced by the need for radiology services (66.3%), specifically mammograms (12.7%), computerized tomography (CT) (39.2%), and lab (18.2%).
Conclusion: Outmigration can negatively impact a county's health care infrastructure and growth and contribute to a loss of revenue to the local hospitals. In this case, out-of-network services are more commonly used for radiology and lab work than for chronic conditions. It is recommended that both physicians and patients become knowledgeable about the impact of seeking out-of-network care
The Importance of Communication in Collaborative Community Development: Lessons Learned from Three Cases
Authors: Leuchtag Arin , Bressler Luke , Banks Ashley , Skinner Daniel
Published: August 2022

Collaborative community development projects aimed at promoting economic vitality, with attendant consequences as a key social determinant of health, necessarily pose questions about how to best communicate between developers, project partners, and community members. Many such projects are taking place across the United States, including in Ohio. This commentary draws on examples from 3 communities (2 outside of our state of Ohio, and another in the Linden neighborhood of Columbus, Ohio) to distill 3 key lessons in the area of communication. First, we argue that communication should be proactive, not reactive. Second, we explain why planners should be consistent in the provision of updates related to progress or lack thereof in real time on websites and apps, all while ensuring that information remains current. Third, though communication remains an under-appreciated aspect of partnership-based community development work, including explicitly health-oriented work, we argue that communicating progress to community members is not only logistically important, but part of a broader effort to build trust within communities in order to create long-lasting and sustainable change. This trust, after all, is a necessary foundation for community-focused workconcerned with addressing the social determinants of health.
Increasing Parenting Self-Efficacy Through a Community Partnership in Akron, Ohio
Authors: Sues-Mitzel Annette , Coffey Alexandria M. , Espe-Sherwindt Marilyn , Gothard Dave , Maglionico Deborah , Ekers Heather , Holmes Ameeca , Hale-Johnson Monika , Wuensch Heather , Douglas Mary
Published: August 2022

Background: The Nurturing Family Program (NFP) is a family-centered educational curriculum designed to equip parents with tools and techniques to support a nurturing relationship with their child. While there have been many evaluations of the NFP, no evaluations to date measure how the curriculum may influence parenting self-efficacy, how confident a caregiver feels about their ability to foster their child’s development and success, or parenting stress.
Methods: This community-based interventional study used a convenience sample of families recruited from community agencies or within a pediatric medical center. Families with one or more children aged 0 to 5 years, premature infants or an infant discharged from the neonatal intensive care unit (NICU), and/or adolescent parents were invited to participate in NFP. Participants were recruited from community agencies that were most likely to work with populations meeting program eligibility criteria. The NFP was offered as in-home and community-based sessions. The primary outcome of interest was perceived parental self-efficacy, measured using the Tool to Measure Parenting Efficacy (TOPSE) at weeks 1, 5, and 10. The secondary outcome of interest was perceived level of stress, as measured by a visual analog scale each week.
Results: Participants of community-based sessions (n=45) experienced a significant increase in parenting self-efficacy at week 10, compared to week 1 and week 5 (p <0.01). Overall, participants of the community-based sessions experienced an average increase of 17.7 points on the TOPSE scale (p =0.014). Across all participants (n=79), each session attended resulted in a modest, but significant, 3% reduction in stress (p =0.021).
Conclusion: The NFP improved parental self -efficacy among participants of the community-based sessions and reduced perceived stress for all participants.
Depressive Symptoms and Perception of COVID-19 Risk in Ohio Adults
Authors: Bischof Katarina M. , Chakraborty Payal , Miller William C. , Turner Abigail Norris
Published: August 2022

Background: We assessed the relationship between depressive symptoms and perceived COVID-19 risk in the next month.
Methods: This analysis used survey data collected during a July 2020 cross-sectional study using a household-based probability sampling design. A total of 615 noninstitutionalized, English- and/or Spanish-speaking adults in Ohio were included. Depressive symptoms screening occurred using the Patient Health Questionnaire-2 (PHQ-2). We applied survey weights so that presented analyses represent the adult population in Ohio. We performed log-risk regression modeling (generalized linear model with binomial distribution and log link) to estimate unadjusted and covariate-adjusted prevalence ratios examining the association between screening positive for depressive symptoms and perceived risk of COVID-19 in the next month.
Results: The study population was majority female (59.1%) and White (90.3%). The mean age was 55.9 years (standard deviation (SD)=17.3). About 1 in 20 (4.6%) screened positive for depressive symptoms. A positive depressive symptoms screen was not significantly associated with perceived risk of COVID-19 in the next month (prevalence ratio [PR]=0.75; 95% confidence interval [CI]=0.25–2.24). After confounder adjustment, the adjusted prevalence ratio (aPR) was nearly unchanged (aPR=0.78; 95% CI=0.24–2.55).
Conclusion: As depression is often associated with anxiety and pessimism toward the future, the lack of association between depressive symptoms screening and perception of COVID-19 risk in the next month is surprising. Social withdrawal, which is also associated with depression, may have concealed any increased perceived COVID-19 risk, as depressed individuals who remained socially isolated may have had lower perceived COVID-19 risk.
From Procurement to Consumption: A Model to Understand Nutrition Policy Implementation in Permanent Supportive Housing
Authors: Russell Rebekah J. , McIntosh Briana , Palmer Nicole R. , Taggart Morgan , Trapl Erika
Published: August 2022

Background: Food insecurity has become an increasingly complex public health issue across the United States, particularly among various people battling with current or previous homelessness. This project sought to understand the food system in permanent supportive housing sites (PSH) that serve formerly homeless individuals and to explore the use of nutrition standards, specifically the Food Service Guidelines for Federal Facilities (FSGFFs), in this context.
Methods: Participants were members of the administrative staff involved in the food procurement process, food preparation, administrative tasks, and daily operations in a small-intensive program managed by a local nonprofit agency that serves 12 adults over the age of 18 who experience chronic homelessness and persistent mental illness, or substance use disorders, and a second PSH site that helps 41 low-income adults with health conditions experiencing homelessness. The PSH Inquiry Tool (PSH-IT) was developed to better understand the business operations at each site, and the PSH Audit (PSH-A) was created to assess the applicability of FSGFF at each site.
Results: Findings suggest that funding mechanisms, staff training, staff capacity, and access to nutrition education were critical barriers to the successful development and implementation of nutrition standards in PSH sites. Furthermore, findings suggest that adaptations to FSGFFs are required before implementation at PSH sites.
Conclusion: This report advocates for increased involvement of community stakeholders to support nutrition policy development and implementation, a nutrition policy that impacts all levels of the food system from procurement to consumption, and local, state, or federal policy changes to support improved nutrition in PSH.
Digital supply chain procurement transformation
Authors: Omare Frank
Published: August 2022

This chapter demystifies digitalisation and illustrates the benefits it can bring to supply chains. It gives insights into the focus and outcomes of digitalisation and how digital failure might be avoided. As supply chains have become more complex, increased risk has been created, along with a constant pressure to monitor every aspect of the extended supply chain ecosystem. Digitalisation plays a key role in addressing visibility and transparency issues across the supply chain, and helps to improve collaboration between supply chain partners to create more effective supply chains. While digital transformation is a strategic imperative for many organisations, improving connectivity and increasing access to, and distribution of, critical data, many organisations fail to re-engineer their business processes and dedicate insufficient resources to deploy such technology effectively.
Urbanización informal, giro constitucional y activismo judicial en Colombia
Authors: Peña Porras Diego Isaías
Published: August 2022

El artículo presenta un análisis de la tensión jurídica provocada por la urbanización informal en relación con los derechos a la propiedad y la vivienda en Colombia. En torno a dicha disputa se describe la forma como la jurisdicción constitucional colombiana ha dado respuesta al fenómeno. Se sostiene que el juez se enfrenta a una difícil situación en estos eventos, derivada de la ausencia de una política pública habitacional eficaz para los sectores de menores ingresos. Ello ha conducido a un activismo judicial materializado en decisiones que oscilan entre una fuerte intervención en las funciones administrativas del gobierno y la dilación del efectivo cumplimiento de derechos constitucionales. En contraste, parecen ausentes decisiones que contribuyan a encontrar soluciones estructurales al problema.
​Exploring Inhibitory Potential of Curcumin against Multiple Targets Involved in the Cancer Progression, Metastasis and Apoptosis Pathways by in silico Molecular Docking
Authors: veni P. Krishna , Thangapandiyan M. , Raja P. , Rao G.V. Sudhakar
Published: August 2022

Background: Cancer is a multifactorial disease characterized by altered gene expression and one of the most leading causes of death in the world. Curcumin obtained from Curcuma longa known to exhibit anti-inflammatory, antioxidant as well as anti-cancer properties. The present study was undertaken to know different targets through which curcumin acts to elicit the antitumor effect. Methods: In this present study in silico interaction of curcumin with different cancer targets were analyzed by molecular docking using Biovia Discovery studio 4.0. Proteins were selected based on their role in cancer pathways which include transcription factor Nf-kB p50 and p65 subunit, Matrix metalloproteinase involved in invasion and metastasis, cell cycle regulator cyclin D and apoptotic factor Bax. Result: Curcumin found to interact with all the selected proteins with high dock score of 125.428, 94.778, 114.5,111.731,98.6844 with Nf-kB p50, p65 subunits, MMP9, Cyclin D1 and Bax proteins, respectively. Amino acid residues to which curcumin interact, number of hydrogen bonds and hydrogen bond length also predicted. RMSD (Root Mean Square Deviation) value was found to be one in all the interactions. Based on the molecular interaction studies and ADME (Absorption Distribution Metabolism Excretion) predictions it was found that curcumin can act as potent inhibitor of many cancer targets and can be used as a starting molecule for the design of anticancerous drug.
Obsessive-Compulsive Disorder and Illness Anxiety: Examining Commonalities and Comorbidity
Authors: Knowles Kelly A. , Jakes Kavi S. , Olatunji Bunmi O.
Published: August 2022

Obsessive-compulsive disorder (OCD) and illness anxiety disorder (IAD) often co-occur. Cognitive-behavioral models of both disorders overlap and include maladaptive attentional processes, misinterpretation of thoughts and physical sensations, and engagement in repetitive behaviors in an attempt to reduce associated distress. Given commonalities in their presentation and their common co-occurrence, it is important to understand how illness anxiety affects the presentation and treatment of OCD. In this article, theoretical conceptualizations of OCD and IAD and their comorbid presentation are outlined, and assessment and differential diagnosis of these conditions are discussed. Despite shared cognitive vulnerabilities and behavioral patterns, well-validated symptom measures, along with careful functional analysis, can be used to distinguish between OCD, IAD, and comorbid presentations. Best practices for the cognitive-behavioral treatment of these co-occurring conditions are also presented, with suggestions based on both the empirical literature and detailed case studies. Finally, recommendations for future research on co-occurring OCD and IAD and their treatment are explored.
A Study on Government Commitment, Public Capital, and Trade
Authors:   IAGBT, Lee Yang-Seung
Published: August 2022

Purpose – Political populism can leave a negative impact upon social welfare with weakening commitment credibility. It is widely known that public policy plays a role in determining trade gains. The purpose of this paper is to examine how political populism affects the social welfare of an open economy.
Design/Methodology/Approach – This paper extends the Brander-Spencer model in which home and foreign firms compete in oligopoly in a third country. In that model, social welfare is defined as the sum of home firm profits. Strategically, home and foreign firms schedule output to maximize firm profits. Firms can make investments privately to reduce the marginal cost. This paper supposes that a government invests in public capital to inspire private investments. The public investment of the home government benefits the home firms.
Findings – The project of public capital investment takes time until completion. That is, it will be completed in the future. Thus, commitment credibility matters. Specifically, politicians have incentives to reschedule the on-going project of public capital investment in their best political interest. This is the main reason why many public projects encounter hold-up problems. Political populism lies at the center of the problems.
Research Implications – This paper emphasizes that commitment credibility is important as along with the size of the public project. Although the size of a public project is large, the private sector does not respond to the commitment if it lacks credibility. Thus, policymakers should keep in mind that commitment credibility is a necessary condition for the success of a public project.
Surgical effects of rehabilitation protocols on dental arch occlusion of children with cleft lip and palate
Authors: Jorge Paula Karine , Chagas Níkolas Val , Ambrosio Eloá Cristina Passucci , Carrara Cleide Felício Carvalho , Valarelli Fabrício Pinelli , Machado Maria Aparecida Andrade Moreira , Oliveira Thais Marchini
Published: August 2022

Aim: to evaluate the surgical effects of two rehabilitation protocols on dental arch occlusion of 5-year-old children with or without cleft lip and palate. Methods: this is a retrospective longitudinal study the sample comprised 45 digitized dental casts divided into followed groups: Group 1 (G1) – children who underwent to cheiloplasty (Millard technique) at 3 months and to one-stage palatoplasty (von Langenbeck technique) at 12 months; Group 2 (G2) – children who underwent to cheiloplasty (Millard technique) and two-stage palatoplasty (Hans Pichler technique for hard palate closure) at 3 months and at 12 months to soft palate closure (Sommerlad technique); and Group 3 (G3) – children without craniofacial anomalies. Linear measurements, area, and occlusion were evaluated by stereophotogrammetry software. Shapiro-Wilk test was used to verify normality. ANOVA followed by posthoc Tukey test and Kruskal-Wallis followed by posthoc Dunn tests were used to compared groups. Results: For the measures intercanine distance (C-C’), anterior length of dental arch (I-CC’), and total length of the dental arch (I–MM’), there were statistical differences between G1x G3 and G2xG3, the mean was smaller for G1 and G2. No statistically significant differences occurred in the intermolar distance and in the dental arch area among groups. The occlusion analysis revealed significant difference in the comparison of the three groups (p=0.0004). Conclusion: The surgical effects of two rehabilitation protocols affected the occlusion and the development of the anterior region of the maxilla of children with oral clefts when compared to children without oral clefts.
The psychological impact of social distancing related to the covid-19 pandemic on undergraduate and graduate students in Brazil
Authors: Oliveira Angélica Aparecida de , Silva Lea Assed Bezerra da , Nelson Filho Paulo , Puccinelli Carolina Maschietto , Silva Clara Marina Pereira Cavalcanti , Segato Raquel Assed Bezerra
Published: August 2022

Aim: To evaluate the psychological impact of COVID-19 on undergraduate and graduate students of the Dental School of Ribeirão Preto, University of São Paulo. Methods: Three questionnaires were used: sociodemographic, WHO Abbreviated Quality of Life Inventory, and General Anxiety Disorder-7. Data were analyzed using Graph Pad Prism 7a (α = 5%). Mann-Whitney or Kruskal-Wallis and Dunn post-tests were used for statistical comparisons. The Spearman test was used as the correlation test. Results: 257 students responded to the online form that assessed their quality of life and anxiety level. On a scale from 1 to 100, with 100 being the best quality of life, the average obtained was 64.71 (± 13.36). In addition, 87.6% of the students rated their quality of life as good or very good. 74.7% reported good or very good health. The anxiety analysis resulted in an average of 10.04 (± 4.5), indicating moderate anxiety levels. There was an inversely proportional correlation between age and degree of anxiety (p = 0.008, r = -0.1628) and self-perceived learning and student commitment (r = 0.69). Conclusion: Despite the good quality of life and the students’ good self-perception of health, they showed a moderate degree of anxiety during the social distancing caused by COVID-19, also demonstrating a decrease in interest and commitment during distance education.
Functional dentition and associated factors
Authors: Tôrres Luísa Helena do Nascimento , Arenas-Márquez María Jesús , Silva Débora Dias da , Held Roberta Barros de , Almeida Talita Bonato de , Neri Anita Liberalesso , Sousa Maria da Luz Rosário de
Published: August 2022

Studying the different indicators of functional dentition classification can contribute to the understanding of the associated factors, and thus help in the definition of strategies associated with oral health care. This approach has been little explored in the literature, especially when considering the older age group. Aim: The aim of this study is to evaluate the factors associated with three distinct functional dentition classification. Methods: Crosssectional exploratory study using secondary data from the Frailty in Older Brazilians (FIBRA) Project of 876 older adults living in Campinas, Brazil. The indicators of dental function assessed was number of natural teeth present, occluding pairs of teeth and the Eichner index, which were verified by trained dentists, following the World Health Organization criteria for epidemiological studies in oral health. The explanatory variable assessed was the selfperception of oral health-related quality of life measured by the Geriatric Oral Health Assessment Index (GOHAI) and its dimensions. It was also collected sociodemographic information such as age, gender, race/ethnicity, schooling, family income, smoking behavior and frailty status. The association was verified through Poisson regressions for number of teeth and pairs of teeth in occlusion and multinomial regression for the Eichner index, adjusted by sociodemographic and health variables. Results: Lower prevalence of participants with less than 21 teeth who negatively perceived GOHAI´s pain and discomfort dimension and higher prevalence of having less teeth among the ones that negatively perceived GOHAI´s physical and functional dimensions. No association was found between the perception of quality of life and occlusion pairs of teeth and the Eichner Index. Conclusion: Two out of three indicators assessed were associated with quality of life. Therefore, it is important to select sensitive indicators to be able to identify and better comprehend this relationship.
TOTAL DİZ ARTROPLASTİSİ SONRASI KLİNİK SONUÇLAR VE HASTA MEMNUNİYETİ: KİMLER DAHA MEMNUN?
Authors: KORKMAZ İzzet , KORKMAZ Nurdan
Published: August 2022

AMAÇ: Primer diz osteoartriti nedeni ile total diz artroplastisi (TDA) uygulanan hastaların ağrı, fonksiyonel durum ve memnuniyet düzeylerini değerlendirmek ve memnuniyet düzeyi ile demografik ve klinik özellikler arasındaki ilişkiyi incelemek amaçlanmıştır.

GEREÇ VE YÖNTEM: Evre III veya IV primer diz osteoartriti nedeniyle TDA uygulanmış, operasyon üzerinden bir yıl geçmiş ve yeterli takibi olan 44 hastanın kayıtları retrospektif olarak tarandı. Demografik ve klinik özellikleri kaydedildi. Operasyon öncesi ve operasyon sonrası birinci yılda Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) ağrı şiddeti ve fonksiyonu değerlendirmek için kullanıldı. Hastaların operasyon sonrası birinci yıldaki memnuniyet düzeyi 5 puanlık bir likert skala ile değerlendirildi.

BULGULAR: Tüm WOMAC skorları (WOMAC-ağrı, WOMAC-tutukluk, WOMAC-fonksiyon ve WOMAC-total) cerrahi sonrası birinci yılda cerrahi öncesine kıyasla istatistiksel anlamlı olarak düşüş gösterdi. TDA sonrası birinci yılda çok memnun ve memnun olan hastaların oranı %93,2 idi. Memnuniyet düzeyi, tüm WOMAC skorları ile istatistiksel olarak anlamlı negatif ilişki gösterdi. Kadın, yalnız yaşayan, bekar/dul, egzersiz programına devamlılık göstermeyen ve diğer vücut bölgelerinden kaynaklanan kas-iskelet ağrısı olanların memnuniyet düzeyi daha düşüktü (tüm p
Ameliyat Öncesi Perforatör Tayininde Dinamik İnfrared Termografi ve El Doplerinin Başarısının Karşılaştırılması
Authors: SERT Gökhan
Published: August 2022

Amaç: Termografik görüntüleme, perforatör flep cerrahisinde ameliyat öncesi perforatör tayini için kullanılan farklı yöntemler arasında güncel bir seçenek olarak öne çıkmaktadır. Bu amaçla en sık kullanılan yöntem ise el dopleri ile muayenedir. Çalışmada farklı etiyolojiler sonucunda ortaya çıkan defektlerin onarımında kullanılan perforatör fleplerin perforatör tayininde, dinamik infrared termografi (DIRT) ve el dopleri ile muayene tekniklerinin başarılarının karşılaştırılması amaçlanmıştır.

Gereç ve Yöntem: Kliniğimizde Mayıs 2021 – Aralık 2021 tarihleri arasında perforatör flep cerrahisi gerçekleştirilen hastalara ait kayıtlar retrospektif olarak incelendi. Tüm hastaların el dopleri ve termal görüntüleme ile yapılan işaretlemeleri ve ameliyat içi bulguları değerlendirildi.

Bulgular: Toplam 11 hastanın %54,5‘inde etiyoloji travma, %36,3‘ünde tümör rezeksiyonu ve %9,2‘sinde yanıktı. Rekonstrüksiyon amacıyla iki hastada medial sural arter perforatör flebi, dört hastada anterolateral uyluk flebi, iki hastada süperfisiyel radial arter perforatör flebi, bir hastada hipotenar serbest flep, bir hastada anterior tibial arter perforatör flebi ve bir hastada derin inferior epigastrik arter perforatör flebi kullanıldı. Ameliyat öncesinde el dopleri ile 11 perforatör sinyali tespit edildi, DIRT ile 19 perforatör lokalize edildi ve ameliyat sırasında toplam 20 perforatör ile karşılaşıldı. Bu perforatörlerin %55’i el dopleri ile işaretlenen perforatörler iken, %95’i DIRT ile tespit edilen perforatörlerdi. İki yöntemin ameliyat öncesi perforatör lokalize etmedeki başarıları arasındaki fark istatistiksel olarak anlamlı bulundu (p=0.005). Komplikasyon olarak hastaların yalnızca birinde ameliyat sonrası üçüncü günde gelişen kompresyon sebepli venöz tromboz ile karşılaşıldı.

Tartışma: Perforatör flep cerrahisinde başarı için en önemli basamaklardan biri perforatörün lokalizasyonunun ameliyat öncesinde doğru şekilde tespit edilebilmesidir. Bu amaçla kullanılan yöntemler içerisinde termografi güncel ve güvenilir bir yöntem olarak öne çıkmaktadır. Dinamik görüntüleme kullanılarak değerlendirmede başarı artırılabilir. El dopleri ile karşılaşılan yanlış pozitiflikler nedeniyle yerine termografi tercih edilebilir.

Sonuç: Perforatör flep cerrahisinde ameliyat öncesi perforatör seçiminde dinamik infrared termografiye izin veren akıllı telefon uyumlu termal kameraların kullanılması, el dopleri ile yapılan değerlendirmelerden daha başarılı sonuç vermektedir.
Rigor and reproducibility: status and challenges for single vesicle analysis
Authors: Nolan John P. , Chiu Daniel T. , Welsh Joshua A.
Published: August 2022

This report summarises the presentations and activities of the SELECTBIO Workshop on Rigor and Reproducibility in EV Research and Single EV Analysis held in San Diego, USA, in December 2021. The motivation for the session was the recognition that progress in the extracellular vesicle (EV) field is limited by the availability of rigorous and reproducible EV measurement tools. These tools are absolutely required for EVs to evolve from a research lab curiosity to something that will improve our ability to understand, diagnose, treat, and prevent disease. The program focused on guidelines for EV measurement and characterization as laid out in the recent MISEV2018 and MIFlowCyt-EV publications, their implementation in routine practice, and their continued evolution as new EV measurement technologies are introduced. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.
EVALUASI STRUKTUR GEDUNG FAKULTAS HUKUM UNIVERSITAS ISLAM INDONESIA YOGYAKARTA BERDASARKAN PERCEPATAN GEMPA YANG DIHITUNG SECARA PROBABILISTIK
Authors: Erlangga Wisnu , Makrup Lalu , Musthofa Malik , Suharyatmo
Published: August 2022

Earthquake shocks generally cause the biggest shocks in building structures. Earthquake waves, generated by an earthquake event, are the main cause of this shaking. A new building of the Faculty of Law, Islamic University of Indonesia, was selected for this research to evaluate the effect of earthquake shaking on the structural response. A developed time history-based artificial earthquake ground motion was used in the structural analysis. Furthermore, the time history was developed based on spectral matching with target spectra derived from a probabilistic seismic hazard analysis. This analysis results in the building structure's seismic response, which is then evaluated based on the parameters set by the earthquake standards/regulations for buildings. This building is relatively safe against design earthquake shocks based on the results.
Sensitivity analysis of the SMARTER and MOORA methods in decision making of achieving students
Authors: Farida Intan Nur , Mahdiyah Umi , Hari Setiawan Akbar Fastio
Published: August 2022

Evaluation of student learning in Islamic boarding schools is still limited to the results of exams conducted in writing which can lead to the determination of student achievement using simple criteria, resulting in less than optimal results. In addition, the importance of selecting criteria to suit the learning characteristics of the Islamic boarding school students. The purpose of this study is to assist the process of evaluating student learning based on the value of the criteria, sub-criteria, and priorities. The method used is Rank Order Centroid in assigning weight values ​​to the criteria applied to the Simple Multi-Attribute Rating Technique Exploiting Ranks (SMARTER) and Multi-Objective Optimization By Ratio Analysis (MOORA) methods. This study produces the same alternative value in the first rank. To calculate the accuracy is done by using sensitivity analysis according to the results of preference values ​​in each method. Based on the sensitivity analysis shows that in the first sensitivity calculation the lowest value is obtained. The sensitivity value of the SMARTER method on the first sensitivity is 0.0714. While the first sensitivity value of the MOORA method is 0.0076. So the best method is owned by the MOORA method because it has the lowest sensitivity value.
Software-based simulation to analyze the variation of digital modulation and atmospheric condition on the free space optic (FSO) link performance
Authors: Khair Fauza , Zulherman Dodi , Auliana Rifani
Published: August 2022

Free Space Optic (FSO) is the solution for telecommunications technology that offers high data rates, wide bandwidth, and low power consumption. However, to maximize the performance of the FSO system, the modulation used should be considered in environmental conditions. This study aims to compare the performance of the FSO communication link based on digital modulation variations used in various weather conditions, including sunny, rainy, and foggy weather. This study uses two attenuation models, namely the Kim and Kruse models, with variations in transmission distance from 500 meters to 10 kilometers. Modulation variations used include QPSK, 8-PSK, 16-PSK, and 16-QAM at 10 Gbps bitrate. The simulation is accomplished using OptiSystem 17.0 software. The study results show that sunny weather (very clear) has the best visibility compared to rain and fog conditions with an attenuation value of 0.46 dB/km on the Kim and Kruse models. QPSK modulation has the best performance with a BER value of less than 1x10-12 up to a transmission distance of 8 km in sunny weather, 3 km in rainy weather  (medium rain), and 800 m in foggy (moderate fog) weather. The 8-PSK modulation has a BER value of less than 1x10-12 with a range of 2000 m in sunny weather and 1500 m in rainy weather but does not meet the standards in foggy weather conditions. 16-PSK and 16-QAM modulation have above baseline BER values ​​during rainy and foggy conditions, but 16-QAM modulation still has a BER value of less than 1x10-3 during foggy conditions at a distance of 500 m.
The reduction of polynomial degrees using moving average filter and derivative approach to decrease the computational load in polynomial classifiers
Authors: Santoso Dewi Agustini , Gandha Gutama Indra
Published: August 2022

Carbon monoxide is a type of pollutant that is harmful to human health and the environment. On the other hand, carbon monoxide also has benefits for industrial matter. Since the benefits and disadvantages of carbon monoxide, the measurement of carbon monoxide concentration is required. The measurement of carbon monoxide level is not easy moreover with low-cost sensors. The usage of 4 sensors namely TGS2611, TGS2612, TGS2610 and TGS2602 has been used along with feature extractor. The polynomial classifier is required to interpret the feature vector into the amount of substance concentration. The common classifier methods suffer fatal limitations. The polynomial classifiers method offers lower complexity in solution and lower computational effort. Since the involvement of a huge number of data points in the modelling process leads to high degree in the polynomial model. The occurrence of Runge's phenomenon is highly possible in this condition. This phenomenon affects the accuracy level of the generated model. The degree reduction algorithm is required to prevent the occurrence of Runge’s phenomenon. The combination of MAF (Mean Average Filter) and derivative approach as degree reductor algorithm has succeeded in reducing the polynomial model degree. The greater the number degree in the model means the greater the computational load. The model degree reductor algorithm has been succeeded to reduce computational load by 96.6%.
Characterization of Genetic Risk of End-Stage Knee Osteoarthritis Treated with Total Knee Arthroplasty
Authors: Kulm Scott , Kolin David A. , Langhans Mark T. , Kaidi Austin C. , Elemento Olivier , Bostrom Mathias P. , Shen Tony S.
Published: August 2022

Background:

End-stage knee osteoarthritis (OA) is a highly debilitating disease for which total knee arthroplasty (TKA) serves as an effective treatment option. Although a genetic component to OA in general has been described, evaluation of the genetic contribution to end-stage OA of the knee is limited. To this end, we present a genome-wide association study involving patients undergoing TKA for primary knee OA to characterize the genetic features of severe disease on a population level.

Methods:

Individuals with the diagnosis of knee OA who underwent primary TKA were identified in the U.K. Biobank using administrative codes. The U.K. Biobank is a data repository containing prospectively collected clinical and genomic data for >500,000 patients. A genome-wide association analysis was performed using the REGENIE software package. Logistic regression was also used to compare the total genetic risk between subgroups stratified by age and body mass index (BMI).

Results:

A total of 16,032 patients with end-stage knee OA who underwent primary TKA were identified. Seven genetic loci were found to be significantly associated with end-stage knee OA. The odds ratio (OR) for developing end-stage knee OA attributable to genetics was 1.12 (95% confidence interval [CI], 1.10 to 1.14), which was lower than the OR associated with BMI (OR = 1.81; 95% CI, 1.78 to 1.83) and age (OR = 2.38; 95% CI, 2.32 to 2.45). The magnitude of the OR for developing end-stage knee OA attributable to genetics was greater in patients <60 years old than in patients ≥60 years old (p = 0.002).

Conclusions:

This population-level genome-wide association study of end-stage knee OA treated with primary TKA was notable for identifying multiple significant genetic variants. These loci involve genes responsible for cartilage development, cartilage homeostasis, cell signaling, and metabolism. Age and BMI appear to have a greater impact on the risk of developing end-stage disease compared with genetic factors. The genetic contribution to the development of severe disease is greater in younger patients.

Level of Evidence:

PrognosticLevel III. See Instructions for Authors for a complete description of levels of evidence.
Sorafenib alleviates inflammatory signaling of tumor microenvironment in lung cancer
Authors: Cicek Betul , Hayme Serhat , Kuzucu Mehmet , Cetin Ahmet , Yeni Yesim , Genc Sidika , Yildirim Serkan , Bolat Ismail , Kantarci Mecit , Gul Mustafa , Hacimuftuoglu Ahmet
Published: August 2022

Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) in diethylnitrosamine (DEN) induced lung carcinogenesis in male rats and also to examine its probable mechanisms of action. Methods and results: A total of 30 adult male rats were divided into three groups as (1) control, (2) DEN, and (3) DEN+SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum samples were analyzed to determine SOX2 levels. Levels of SOX2, TNF-α and IL-1β were measured in lung tissue supernatants. Lung sections were evaluated histopathologically. Also, COX-2 and JNK were analyzed by immunohistochemistry and immunofluorescence methods respectively. SOR reduced the level of SOX2 that maintenance of cancer stemness and tumorigenicity, and TNF-α and IL-1β levels. Furthermore, SOR reduced lung histopathological structure and suppressed COX-2 and JNK expressionConclusions: These results suggest that SOR reduces inflammation in the tumor microenvironment and decreases the level of SOX2 which has an important role in maintaining cancer stem cell properties.
Vaping is Associated with Less Tooth Loss Among Medical Marijuana Users in the 2020 Behavioral Risk Factor Surveillance System (BRFSS)
Authors: ALHarthi Shatha , Binshabaib Munerah , ALShami Abeer , Abdellatif Hoda , Karimbux Nadeem
Published: August 2022

Background
In the United States (US), the prevalence of periodontitis is adults has been estimated to be as high as 46%, and chronic periodontitis leads to tooth loss. Tobacco use is an established risk factor for periodontitis and tooth loss, but evidence behind the relationship between marijuana use and periodontitis remains unclear. Recent innovations have led health-conscious individuals to switch from smoking to inhaling vaporized tobacco and MM (“vaping”). This paper aims 1) to characterize United States (US) MM users in the 2020 Behavioral Risk Factor Surveillance System (BRFSS); 2) to determine if vaping (compared to other MM use methods) is independently associated with oral healthcare utilization and outcomes and 3) to explore potential effect modification between tobacco and MM use and oral health outcomes.
Methods
Those reporting MM use with valid tobacco use variables were included in the analysis. After descriptive analysis, logistic regression was used to estimate whether method of MM use was independently associated with oral health outcomes in tobacco users and non-users.
Results
Of the 7,077 respondents reporting MM use, 69% smoked, 8% vaped, and 50% were also current tobacco users. In regression analysis, among tobacco users, vaping MM and vaping tobacco were associated with lower odds of having lost six or more teeth (compared to smoking both, and eating/drinking MM). Among tobacco non-users, vaping MM was associated with much lower odds of tooth loss than eating/drinking MM (compared to smoking, odds ratio [OR] vaping 0.40, 95% confidence interval [CI] 0.22–0.72, OR eating/drinking 0.73, 95% CI 0.57–0.95).
Conclusions
Our findings point to a potentially anti-inflammatory effect of vaping MM that deserves further examination. Additional studies should seek to accurately measure both tobacco and MM use, and determine whether there is indeed effect modification in terms of their relationship to oral health outcomes.
The Advantages of Domestic Ear Molding System in Molding Bilateral Neonatal Congenital Auricular Deformities
Authors: Li Jie , Tan Junlong , Yang Denghua , Chen Liyan
Published: August 2022

Background
There are different types of ear molding devices on the market. However, with high cost, the wide application of the ear molding is hindered, especially for children with bilateral congenital auricular deformities (CAD). This study is designed to correct the bilateral CAD with the flexible use of Chinese domestic ear molding system.
Methods
Newborns diagnosed with bilateral CAD were recruited in our hospital from September 2020 to October 2021. For each subject, one ear wore a set of domestic ear molding system, while the contralateral ear used only matching Retractor and Antihelix Former. Medical charts were reviewed to collect data on the types of CAD, the incidence of complications, the initiation and duration of treatment, as well as the satisfaction after treatment. Treatment outcomes were graded into three levels: excellent, good, and poor, according to the improvement of auricular morphology evaluated by both doctors and parents, respectively.
Results
A total of 16 infants (32 ears) were treated with the Chinese domestic ear molding system, which contains 4 cases with Stahl’s ear (8 ears), 5 cases with Helical rim deformity (10 ears), 3 cases with Cup ear (6 ears), 4 cases with Lop ear (8 ears ). All infants accomplished the correction completely. Both parents and doctors were satisfied with the outcomes. No obvious complication was encountered.
Conclusions
Ear molding is an effective nonsurgical treatment for CAD. Molding with Retractor and Antihelix Former is simple and effective. Domestic ear molding system can be flexibly used in correcting bilateral CAD. With this approach, infants with bilateral CAD will benefit more in the near future.
Anchovy booms and busts linked to trophic shifts in larval diet
Authors: Swalethorp Rasmus , Landry Michael , Semmens Brice , Ohman Mark , Aluwihare Lihini , Chargualaf Dereka , Thompson Andrew
Published: August 2022

Biomass fluctuations of small coastal-pelagic fishes represent perhaps the most iconic temporal record of the impacts of natural climate variability on marine ecosystems1,2,3. These fishes are key constituents of the marine pelagic food web as primary feeders on plankton, prey to higher trophic level foragers such as birds, marine mammals, piscivore fishes4,5 and valued for human consumption and industry6. Despite over a century of research, the mechanisms governing their population volatility remain elusive7,8. Here, we use a 45-year record of nitrogen stable isotopes measured in larvae of Northern Anchovy (Engraulis mordax) in the California Current to assess patterns in food chain length. Larval trophic efficiency associated with a shortened food chain increased for boom periods of high adult biomass, during which the ratio of large to small larvae decreased by an order of magnitude. In contrast, the ratio increased during periods of low adult biomass, likely reflecting a higher rate of early larval mortality. For the first time, we connect energy transfer efficiency to early larval survival, which in turn regulates the decadal-scale volatility of anchovy biomass, leading to the proposal of the Trophic Efficiency in Early Life (TEEL) hypothesis. Our findings illustrate a potential for trophic indicators to inform on the condition and recruitment to coastal-pelagic fish populations.
Choice of Isolation method has a significant impact on average murine Telomere Length estimates
Authors: Kidd E. , Meimaridou E. , Williams J. , Metherell LA. , Walley A. J. , Fairbrother UL.
Published: August 2022

Background Telomere Length (TL) and integrity is significantly associated with age-related disease, multiple genetic and environmental factors. We observe mouse genomic DNA (gDNA) isolation methods have a significant impact on average TL estimates. The canonical qPCR method does not measure TL directly but via the ratio of telomere repeats to a single copy gene (SCG) generating an TS ratio. We use an mmqPCR method which multiplexes the PCR and enables quantification of the target and the single copy gene within the same qPCR reaction. Results We demonstrate TL measurements, from murine gDNA, isolated via Spin Columns (SC) and Magnetic Beads (MB), generate significantly smaller T/S ratios compared to gDNA isolated via traditional phenol/chloroform methods. The former methods may impede correct TL estimation by producing non representative fragment sets and reducing qPCR efficacy. Conclusions This work highlights discrepancies in TL measurements due to different extraction techniques. We recommend the use of gDNA isolation methods that are shown to preserve DNA length and integrity, such as phenol/chloroform isolation. We propose that widely used high throughput DNA isolation methodologies can create spurious associations within a sample set, thus creating misleading data. We suggest that published TL associations should be revisited in the light of these data.