bluuebunny/crossref_metadata_2025 huggingface dataset:
Naturaleza jurídica y sentido económico de la responsabilidad "penal" de las personas jurídicas. Reflexiones en relación a la Ley Nº 27.401
Authors: Hernán Goldman Diego
Published: November 2018

La Ley Nº 27.401 representa el intento más completo y exhaustivo de introducir en la legislación argentina la responsabilidad penal de las personas jurídicas. A lo largo de este trabajo, analizaremos si la responsabilidad penal de las personas jurídicas es compatible con los principios constitucionales que rigen nuestro Derecho Penal o si, por el contrario, resulta conveniente mantener la responsabilidad de las personas jurídicas por los delitos cometidos en su nombre o en su beneficio dentro de la órbita del Derecho Administrativo. Asimismo, estudiaremos cómo éstas cuestiones se vinculan con la generación de incentivos para que las empresas adopten programas de compliance, y con la promoción de una mayor eficiencia del sistema penal en su conjunto.
Régimen Legal Mexicano de las Responsabilidades Administrativas
Authors: Polanco Polanco Adrian
Published: November 2018

Inicialmente se hace énfasis en el problema de la corrupción en México, realizando una descripción de la Ley General de Responsabilidades Administrativas y estableciendo parámetros para el análisis del Derecho administrativo sancionador. Describe el Sistema Nacional Anticorrupción, como una instancia a través de la cual se coordinan las autoridades a los tres órdenes de gobierno, para prevenir, detectar y sancionar las responsabilidades administrativas, y los hechos de corrupción, así como lo concerniente a la fiscalización y control de los recursos públicos, que tiene como principal característica la de regular las faltas y las sanciones administrativas, tanto de los servidores públicos y de los particulares. El autor propone un modelo que unifique y permita la aplicación de sanciones administrativas para los servidores públicos y particulares, desde la perspectiva garantista.
Análisis de la Regulación Internacional de las Plataformas Marinas
Authors: Radovich Violeta S.
Published: November 2018

El objetivo del presente artículo consiste en analizar el régimen internacional legal atinente a la actividad de exploración y explotación de hidrocarburos en el mar que llevan adelante las plataformas marinas. Se estudian las distintas convenciones aplicables a las plataformas debido a que no se cuenta con un cuerpo uniforme sobre la temática, tanto desde el Derecho del Mar, el Derecho Marítimo como el Derecho Ambiental. Finalmente, se rescatan los puntos positivos de los proyectos y se señalan las lagunas en la regulación actual.
La reconstrucción racional del Juicio de Hecho: una exigencia de la tutela judicial efectiva
Authors: Merino Martínez Catalina
Published: November 2018

Este artículo persigue analizar la estrecha relación que existe entre la reconstrucción del juicio de hecho en la sentencia y la Tutela Judicial Efectiva como principio rector del derecho constitucional en el marco del Estado Social de Derecho. Y para ello, se pretenderá explicar, a partir de un enfoque hermenéutico propio de la investigación cualitativa, cómo dentro del derecho procesal contemporáneo, la providencia de cierre del sistema no solo resuelve el conflicto de intereses afirmado por las partes, sino que además, tiende a determinar la verdad de los hechos como mecanismo de tutela de los derechos subjetivos reclamados, pero siempre a partir de la valoración racional de la prueba dentro de un contexto de incertidumbre, que exige, como garantía iusfundamental, la presencia de la motivación ante la fragilidad epistémica del resultado del iter decisional.
El Derecho de Acceso a las Videograbaciones de Juicio Oral en el Sistema Penal Acusatorio.
Authors: Vázquez Segura Jorge Alberto
Published: November 2018

El 18 de junio de 2016, entró en todo el territorio nacional el nuevo sistema penal acusatorio a través del Código Nacional de Procedimientos Penales. En el presente texto se realizará un análisis de los diversos puntos de convergencia existentes entre las normas del Código Nacional de Procedimientos Penales (CNPP) y de la Ley General de Transparencia y Acceso a la Información Pública (LGTAIP) para detallar las implicaciones y problemáticas que enfrentan los titulares de los órganos jurisdiccionales federales, así como posibles soluciones, al ser requeridos vía acceso a la información por una videograbación de juicio oral. En estos casos, como se observará más adelante, se tendrá que realizar una ponderación de derechos fundamentales y principios constitucionales.
La Corte Suprema de Justicia de la Nación Argentina y su posición respecto a la educación religiosa en las escuelas públicas
Authors: Basaure Miranda Isaac Marcelo
Published: November 2018

En el presente artículo se analiza la postura adoptada por la Corte Suprema argentina en relación a la educación religiosa en las escuelas públicas. En el reciente fallo caratulado “Castillo, Carina Viviana y otros c/ Provincia de Salta–Ministerio de Educación de la Prov. de Salta. s/ Amparo”, emitido el 12 de diciembre de 2017, el máximo tribunal declaró la inconstitucionalidad del inc. “ñ”, del artículo 27 de la ley Nº 7.546 de la Provincia de Salta -el cual ordenaba brindar enseñanza religiosa dentro del horario de clases en las escuelas estatales-, y dispuso que la educación religiosa sólo puede realizarse fuera del horario escolar. Teniendo como marco conceptual a la Constitución Nacional, a los tratados internacionales ratificados por Argentina, a la jurisprudencia de la Corte Suprema y a la normativa interna; el presente trabajo se propone estudiar el vínculo existente entre la libertad religiosa, el derecho a la intimidad y el derecho a no ser discriminado, a los fines de comprender la postura adoptada por la Corte Suprema, según la cual, la educación pública en Argentina debe ser de carácter laico.
Introducción al Estudio del Derecho, México, Cámara de Diputados, 2018
Authors: Fierro Serna Bernardo
Published: November 2018

l
Derecho a un proceso de muerte digna
Authors: Martínez Navarro Juan Alejandro
Published: November 2018

El debate relacionado con el proceso de muerte ha adquirido gran relevancia en nuestra sociedad. El valor que refleja esta aspiración y los derechos que genera se han situado en primera línea de actualidad. Existe un consenso ético y jurídico bastante consolidado en torno a algunos de los contenidos y derechos del ideal de la buena muerte. En las líneas siguientes se abordan algunos supuestos relacionados con el proceso de muerte digna: el rechazo al tratamiento y la eutanasia. Se reflexionará en relación al derecho a la sedación terminal y la eutanasia considerando su conceptualización, clasificación y naturaleza jurídica. Asimismo se realizará una aproximación a los conceptos de ortotanasia y distanasia, la regulación jurídica y su debate.
Criterios editoriales
Authors: Juarez Quezada Gudalupe
Published: November 2018

l
Análisis crítico del procedimiento voluntario introducido en la ley chilena de protección de consumidores y usuarios como mecanismo alternativo de solución de conflictos colectivos
Authors: Aguirrezabal Grünstein Maite Arantzazu
Published: November 2018

El presente trabajo analiza la progresiva implementación de mecanismos alternativos de solución de conflictos en la legislación que protege a los consumidores y usuarios, con especial referencia a la mediación colectiva y su adecuada configuración.
Liquidación de sentencia
Authors: Abal Oliú Alejandro
Published: November 2018

En este artículo se trasmiten las conclusiones de la investigación cumplida en torno al campo normativo, a las principales reflexiones académicas y a la jurisprudencia más relevante, sobre el procedimiento que el Código General del Proceso de Uruguay regula bajo el nombre de “Liquidación de sentencia”.
Corrección y facticidad
Authors: Leiva Rabael Antonio
Published: November 2018

Este artículo intenta una explicación de la tesis de la corrección y del caso especial de Robert Alexy y qué respuestas es posible conducir a una de las críticas más prestigiosas que se han elevado en su contra, cual es la que Jürgen Habermas le dirige en su obra Facticidad y Validez[1]. Para ello se explicarán las cuestiones imprescindibles para comprender el concepto de Derecho que brota de esta teoría y los principales argumentos para demostrarla. A continuación, se presentarán las tesis centrales del iuspositivismo metodológico, con el objeto de introducir las principales críticas desplegadas por Habermas respecto de la tesis alexiana del caso especial y de la vinculación entre Derecho y Justicia. Finalmente, se propondrán respuestas a esas críticas.
Reflexiones sobre la judicialización de la designación del Defensor de los Derechos de las Niñas, Niños y Adolescentes en Argentina
Authors: Basaure Miranda Isaac Marcelo
Published: November 2018

El presente artículo tiene como objetivo analizar las causas y antecedentes que han contribuido a que, en Argentina, la designación del Defensor del Niño se haya judicializado. En el fallo caratulado “Fundación Sur Argentina y otros c/en Honorable Cámara de Senadores de la Nación y otro s/Amparo ley 16.986”, (expediente N° 15581/2015), publicado el 9 de marzo de 2017, el Juzgado Nacional de Primera Instancia en lo Contencioso Administrativo Federal Número 3, exhortó al Congreso de la Nación, debido a su dilación, a designar un Defensor del Niño para dar cumplimiento a lo establecido en la ley 26.061.
Presencia de argumentos filosóficos en la jurisprudencia uruguaya
Authors: Guerra Martín
Published: November 2018

El presente constituye el trabajo externo final para el curso de Filosofía del Derecho y consiste, básicamente, en el análisis de la argumentación e interpretación jurídica esgrimida por la mayoría integrada del Tribunal de Apelaciones en lo Civil de 6º Turno en la sentencia N° 37/1996, así como la empleada en la discordia de uno de sus integrantes naturales.

No será objeto de estudio, pues, ningún otro elemento vinculado a la sentencia que podría ser de interés en el caso concreto, como ser la base fáctica sobre la que se asienta el pronunciamiento o la valoración de la prueba que realizó cada ministro. Estos elementos se darán por supuestos.
BIOLOGICAL EVALUATION OF SAUSSUREA LAPPA ROOT EXTRACT FOR ANALGESIC AND ANTI- INFLAMMATORY ACTIVITY
Authors: Tejaswi Juluri Krishna Dutta , Rajan R. Govinda , Sara P
Published: November 2018

The present study was designed to evaluate the Phytochemical Screening for Analgesic and Anti- inflammatory activities of Ethonolic extract of Saussurea lappa.  The collected plant root material were washed, shade dried, and size reduced into small pieces. Dried materials were coarsely powdered and macerated with petroleum ether for 72 hrs. The plant material was extracted by using ethanol by the cold maceration method. The study concluded that the root extract have potential bioactive substances that may be used to formulate new drugs. The Flavo-Glycosides content in Ethonolic extract of Saussurea lappa root was extracted and results were compared with the standard for Analgesic and Anti- inflammatory activities. The results were compared with the standard using statistical method. However further investigation was required for structural elucidation and pharmacological properties.

Keywords: Saussurea lappa, Ethonolic, Glycosides, Analgesic, Anti-inflammatory.
CIPROFLOXACIN HYDROCHLORIDE LOADED CHITOSAN NANOPARTICLE GEL: ADVANCED APPROACH FOR ENHANCING PERMEATION AND SUSTAINABILITY OF DRUG RELEASE
Authors: Dev Dhruv , Bhardwaj Urvashi , Prasad D N
Published: November 2018

Transdermal drug delivery is one of the most reliable, appealing and effective technique which provides controlled and constant administration of drug. The aim of the study was to develop a gel form of nanoparticles loaded with ciprofloxacin hydrochloride in order to enhance the permeability of drug and for the release of drug over a period of 24 hrs. The nanoparticles were formulated by ionic gelation method using chitosan as a polymer and TPP as a cross linking agent. The compatibility of drug and polymer is studied by using FTIR spectroscopy and DSC method. There was no interaction observed by UV and FTIR study. The six different batches were prepared using different polymer and drug ratio. The fourth batch (N4) shows best results as compared to others which was used for further investigations. The formulation was then optimized for its particle size, zeta potential, morphology, drug content, drug entrapment efficiency, drug loading capacity and in-vitro permeation. TEM study reveals that the nanoparticles are spherical in shape and also confirms the size below 500nm. Drug release studies shows that nanoparticles could release drug for 24 hrs and follows zero order kinetics. From DSC analysis it was found that the drug was effectively encapsulated inside the chitosan nanoparticles. Finally, it was concluded that the penetration of ciprofloxacin hydrochloride was enhanced after loading it into chitosan nanoparticles and also the drug was release over 24 hrs.

 

Keywords: Nanoparticles, Ciprofloxacin Hydrochloride, Chitosan, Carbopol 934
FORMULATION AND EVALUATION OF DISPERSIBLE PELLETS OF LAGENARIA SICERARIA
Authors: Dudhamal S S , Kawtikwar P S , Nagoba S N
Published: November 2018

Lagenaria siceraria (Bottle gourd) is a common name in every household. Its medicinal values were identified many years ago, and still people use this plant for many disorders. Extrusion spheronization technique was employed for preparation of the pellets, to study the effect of crosscarmellose sodium, on it. The pellets were prepared by use of combination of Avicel PH 101 and lactose that indicated good flow properties. The superdisintegrant used was crosscarmellose sodium between concentration 2 to 8%, to study the effect of it on the pellets. The superdisintegrant showed low disintegration time at low concentration, while as the concentration of it increased, it extended the disintegration time. Thus, optimum concentration needs to be designed for successful formulation. Batch D3 of 6% crosscarmellose sodium concentration showed the requisite characteristic in terms of all the evaluation parameters, with DT up to 50 to 55 seconds. Thus, use of this superdisintegrant alone, but in low concentration, can be helpful, or else combination of this with other superdisintegrants can be approached, or else new superdisintegrants can be tried. Thus, the study indicated the effect of superdisintegrant for formulation of dispersible pellets.

Keywords: Extrusion-Spheronization,  Crosscarmellose sodium, Lagenaria siceraria, Pellets
A REVIEW ON THE EFFECTIVENESS OF CURRENT APPROACHES TO STRESS MANAGEMENT
Authors: Dubey Chetan Kumar , Chaturvedi Sarika , Chaturvedi Shilpi
Published: November 2018

Stress is your body’s way of responding to any kind of demand or threat. When you sense danger—whether it’s real or imagined—the body's defenses kick into high gear in a rapid, automatic process known as the “fight-or-flight” reaction or the "stress response. The stress response is the body’s way of protecting you. When working properly, it helps you stay focused, energetic and alert. In emergency situations, stress can save your life—giving you extra strength to defend yourself, for example, or spurring you to slam on the brakes to avoid an accident. Stress can also help you rise to meet challenges. It’s what keeps you on your toes during a presentation at work, sharpens your concentration when you’re attempting the game-winning free throw, or drives you to study for an exam when you'd rather be watching TV. But beyond a certain point, stress stops being helpful and starts causing major damage to your health, your mood, your productivity, your relationships, and your quality of life.

Keywords- Stress, psychology of stress, HPA axis, ACTH
Significance of Doshas in Management of various Disease
Authors: Asthana Alok Kumar , Asthana Monika Monika , Sahu Renu
Published: November 2018

In Ayurveda, the span of life is described to be determined on the basis of nature of the physique, type of constitution. The utility of Ayurveda is to help maintain the health of a healthy individual and cure of disease of a patient. In our ancient text, the pathogenic factor in the body are Vayu, Pitta and Kapha, while those in the mind are Rajas and Tamas. Out of three. qualities (Gunas) of mind viz., Sattva, Rajas, Tamas, it is only the latter two that cause vitiation of the mind, the former one being non-pathogenic.In other words, Vayu, pitta and Kapha are, somatic Doshas and Rajas and Tamas are the psychic ones. These three Doshas when vitiated harmful to our Dhatu (tissue) and donate life in an unvitiated state, which means helping in the acquisition of health.so for the healthy life equilibrium of Doshas is mandatory.

KEY WORDS: Vata, moksha, pitta, kapha, shleshma.
Simultaneous Spectrophotometric Determination of Paracetamol, Propyphenazone and Caffeine By Using Absorption Ratio Method
Authors: Pulungan Ainil Fithri , DLP. Effendy , MS. Siti
Published: November 2018

The Absorption Ratio method involves measuring the absorbance at two wavelengths, namely the iso-absorptive point and the maximum wavelength. Its method could be an option in determining the level of a drug. The aim of this study was to determine whether the absorption ratio method can be used to determine the levels of paracetamol (PCT), propyphenazone (PRO) and caffeine (CAF) in tablet form. The absorption ratio method was used to determine the levels of the mixed drug compound without the separation stage and using the maximum wavelength and iso-absorptif point. The result of the study showed that the absorption ratio method used to solve multicomponent problems in tablet form can be performed and satisfy the validation requirements of the method according to international Conference on Harmonization Q2 (R1) (ICH) guidelines. The absorption ratio method was a simple and accurate to be used determine PCT, PRO, CAF in tablet form.

Keywords : Paracetamol, propyphenazone, caffeine, absorption ratio
RECENT INSIGHTS ON PROSPECTS OF CANCER NANOTECHNOLOGY
Authors: Sharma Hemant K. , Kumar Manish
Published: November 2018

Cancer is an extremely multifaceted illness to appreciate, since it entails manifold cellular physiological system. The mainly general cancer treatment is limited to chemotherapy, radiation and surgery. Furthermore, the untimely credit and action of cancer relics a technological block. There is an urgent require to expand novel and originaltechnology thatcould help to define tumor margins, recognize residual tumor cells and micro metastases, and decide whether a tumor has been totally removed or not. Nanotechnology has witnessed significant progress in the past few decades, and its effect is widespread nowadays in every field. Nanoparticles can be modified in numerous ways to prolong circulation, enhance drug localization, increase drug efficacy, and potentially decrease chances of multidrug resis­tance by the use of nanotechnology. Recently, research in the field of cancer nanotechnology has made remarkable advances. In present study review summarizes the application of various nanotechnology-based approaches towards the diagnostics and therapeutics of cancer.

Key-Words:Cancer Nanotechnology, Liposomes, Targeted Delivery, Diagnosis, Nano-medicines.
FORMULATION AND EVALUATION OF ITRACONAZOLE NIOSOMAL GEL
Authors: Kumar Ashish , Dua J.S
Published: November 2018

The preparation of niosomes. The main objective of the study was to enhance the antifungal activity of the formulation.  Itraconazole is a broad spectrum Imidazole derivative useful in the treatment of superfacial and systemic fungal infection. Various surfactants used were span 40 and span 60. Niosomes were prepared by using Rotary Vaccum evaporation method. Niosomes were prepared using different ratio of drug: surfactant: cholesterol (1:1:1, 1:2:1, 1:3:1).Evaluation of the Niosomal gel was done by determination of drug content 52.81-56.12, Entrapment Efficiency 42.20-45.20,Niosomal gel was prepared using Carbopol 940 (1.5%), Glycerol (10%), Triethanolamine (q.s.) and distilled water up to 15ml. Viscosity was determined by Brookfield programmable ultra-viscometer and the ranges 8173 centipoise. The drug content of the Itraconazole niosomal gel was determined at 262 nm against blank by using UV/visible spectrophotometer and found to be 56.12%. The percentage of drug entrapment in niosomal gel was calculated to be 45.20% .The in-vitro drug release study was carried out using phosphate buffer saline pH 7.4 and was found to be 41.18 ± 1.53% for 12 hours. It can be concluded that the gel formulation containing niosomes loaded with Itraconazole showed prolonged action than formulation containing Itraconazole in non-niosomal form and it can be developed successfully to improve the anti-fungal activity.
FORMULATION, CHARACTERIZATION AND EVALUATION OF ANTI-INFLAMMATORY AND ANTI-ANGIOGENIC ACTIVITIES OF MEMECYLAENE NANOEMULSION
Authors: Rekha ND , Nagesha Dattatri K. , Rajasree PH , Shruthi N
Published: November 2018

The present study was undertaken to formulate and evaluate the anti-inflammatory, anti-oxidant and anti-angiogenic activities of nanoemulsion of Memecylaene.  Memecylaene was isolated from the leaves of Memecylon malabaricum by using various chromatographic methods. An oil-in-water (O/W) nanoemulsion of Memecylaene was formulated by sonication method using sunflower oil (oil phase), Tween 80 (Surfactant) and Ethanol (co-surfactant). The prepared nanoemulsion was characterized for its droplet size, poly dispersity index and zeta potential. Stability studies were performed and the nanoemulsions were subjected to different biological activities. The formulated nanoemulsion had a particle size range of 52.02 nm to 59.47 nm and zeta potential of -1.27 mV. The enhanced activity of Memecylaene, encapsulated in O/W emulsions is evidenced by the inhibition of phospholipase (PLA2) enzyme and H+, K+ -ATPase and thus showing anti-inflammatory and anti-secretagogues effects. The in vitro anti-oxidant activity was evaluated by DPPH radical and Nitric oxide radical scavenging activity. Further, the inhibition of the growth of neo vessels formation in the in-vivo model system of chick chorioallantoic membrane (CAM) assay, which is angiogenesis dependent, was also observed. The above findings would help in understanding the putative potential of Memecylaene-loaded nanoemulsion as a therapeutic agent.

Keywords: Anti-angiogenesis, Anti-oxidant, Gastric (H+ K+), Memecylaene, Nanoemulsion, Phospholipase A2 (PLA2).
EDX AND XRD, FT-IR SPECTRA, ANALYSIS CONTAINING HEXAVALENT CHROMIUM METAL ION ADSORPTION PRESENT IN AQUEOUS SOLUTION ON TO PHOSPHORIC ACID (H3PO4) ACTIVATED MIMUSOPS ELENGI LEAVES CARBON
Authors: Elavarasan A
Published: November 2018

Adsorption studies were carried out by observing the effects of various experimental parameters removal of Chromium from Aqueous solution. Morphology of adsorbent due to adsorption has been analyzed PH, FT-IR spectra, EDX and XRD analysis. Adsorption interactions of hexavalent chromium metal ion onto PTMAC and STMAC from aqueous solution. Using FT-IR spectra, and XRD techniques.and EDX studies revealed that the possibility of partial chemisorption though maximum adsorption is physical in nature. EDX showed the morphological observations of loaded and unloaded adsorbents. XRD studies exhibited the crystalline nature of unloaded adsorbent compared with loaded adsorbent.

Keywords: PH, FT-IR spectra, EDX and XRD analysis, PTMAC, STMAC.
SUN PROTECTION FACTOR DETERMINATION STUDIES OF SOME SUNSCREEN FORMULATIONS USED IN COSMETICS FOR THEIR SELECTION
Authors: Khan Masheer Ahmed
Published: November 2018

The study involves determination of sun protection factor (SPF) values of some sunscreen formulations for their use in cosmetics.  The Sun Protection Factor (SPF) is a very popular instrument in the marketing of sunscreens. Sun protection factor is a laboratory measure of the effectiveness of sunscreen, the higher the SPF, the more protection a sunscreen offers against the ultraviolet radiations causing sunburn. It is often not understood how sunscreens work and where the limitations of the SPF are. A lot of aspects of the SPF are confusing, e.g. the race for higher and higher numbers, the effect on SPF when less sunscreen is applied and if sunscreen should be used at all because they may block the Vitamin D synthesis. The study explains how sunscreens work, how the SPF is determined and where the limitations of the current methods exist. The dynamic view of 'UV radiation applied' and the 'UV dose transmitted' through the sunscreen onto the skin as well as onto a substrate in vitro help in the understanding and are also promising approaches in the in vitro assessment. The study is helpful in selection of some sunscreens formulations used in cosmetics with better safety and high SPF values.

Keywords: Sun Protection Factor, SPF, Sunscreens
IN-VITRO AND IN VIVO STUDIES OF CETUXIMAB LOADED POLYMERIC NANOPARTICLES
Authors: Kaushik Ajinder , Sharma Hemant Kumar
Published: November 2018

Nanoparticles speak to one of the appealing choices in the compelling treatment of tumor chemo-treatment. In the present work, definition and improvement of a novel Cetuximab (MTX)- stacked biodegradable nanoparticles utilizing poly(D,L-lactide-co-glycolide) (PLGA) was done. The arranged nanoparticles were assessed for physicochemical properties, for example, molecule measure, zeta potential, discharge thinks about, and so forth. Molecule size of upgraded definition was < 200 nm. Our essential outcomes exhibit that the created Cetuximab-stacked PLGA nanoparticles discharging the medication for delayed timeframe.

Keywords: Cetuximab; PLGA 50:50; nanoparticles
RECENT PROMISING ADVANCES IN DEVELOPMENT OF ANTIMICROBIAL AGENTS: A REVIEW
Authors: Maqbool Mudasir , Ishaq Geer Mohamed
Published: November 2018

Antimicrobial resistance is a serious global threat. There is a global menace of antibiotic resistant “super bug”, though the extent and the severity of the problem varies. Resistance hampers therapeutic options and drives clinicians to use newer and more expensive drugs. In serious cases, multi-resistance provides no treatment options. To overcome resistance, a continuous supply of new antibiotics offers an obvious way; but the pipeline of agents in development by the Pharmaceutical industry is very limited. There is an ever-evolving need to develop and evaluate newer alternative strategies for countering a worsening clinical situation to overcome resistance and reduce the morbidity and mortality associated with infections caused by antibiotic-resistant bacteria. The widespread distribution of Antimicrobial resistance has not been paralleled by the development of newer antimicrobials. This happens due to the process of drug discovery and clinical trials of new antimicrobials taking longer time and only a fewer new agents been approved for use. In modern era, where obstacles like chemo-resistance and mutations torment medicine, scientists across the world are looking to adapt lateral approaches in encountering diseases.

Keywords: antimicrobial resistance, super bug, antibiotics
ANATOMICAL STUDIES ON CORBICHONIA DECUMBENS (FORSSK.) EXELL, AN IMPORTANT MEDICINAL HERB FROM RAJASTHAN
Authors: Arora Sunita , Saini Manju
Published: November 2018

Corbichonia decumbens (Forssk.) Exell, commonly known as pater-chatti, is an annual or short lived perennial herb found in rocky habitats. It is used to cure kidney stone and gonorrhoea. The main objective of this study was to examine the anatomical characters of whole plant of C. decumbens for identification. The transverse sections of root, stem, leaf and flower have been examined and analysed. Photomicrographs were prepared with Sony HD (1920x1080/50i) digital camera. The microscopical studies revealed several interesting features viz., the presence of anomocytic stomata on both the surface; more on adaxial surface starch grains present in cortical region of root, rosette crystals in almost all vegetative parts that some time forms clusters, sclerenchymatous pericyle in stem and root presence of wide medullary rays in secondary xylem and bundle sheath around vascular bundles. The outcome showed many unique characters which may prove most important in taxonomical relevance. This study would be useful for correct identification and authentication of the plant.

Keywords: Anomocytic, Dorsiventral, Medullary rays, Bundle sheath, Rosette crystals
ANTIOXIDANT ACTIVITY (PHENOL AND FLAVONOID CONTENT ) OF THREE DIFFERENT CULTIVARS OF PIPER BETLE L. (PIPERACEAE)
Authors: HARINI SAPARA SEKHAR , Sougandhi Pagadala R , TENKAYALA DR SHOBHA RANI , Gopinath Kamalamma Ramalingam
Published: November 2018

In the present study, an attempt has been made for the estimation of total phenol and flavonoid content and their radical scavenging properties using Piper betle (L.) leaves. In that, Cultivars i.e., Nov Bangla (NB), Sirugamani-1 (SGM-1) and Halisar Sanchi (HS) were selected for this study. The total phenolic content was ranged from 95.04 to 127.33 mg/100g equivalent to gallic acid and flavonoids were ranged from 51.72 to 61.08 mg/ 100g equivalent to standards of Catechin.  In vitro antioxidant activity was estimated using 1,1-diphenyl-2-picryl hydrazyl (DPPH), free radical scavenging activity, improved ABTS radical cation decolorization assay and ferric reducing antioxidant power (FRAP) assay. Among all the cultivars, The highest Phenol content (93.79%) was observed  for Sirugamani-1 by DPPH method  and highest Phenol content (96.12% & 6791.86 (µg/g) was obtained  for Halisar Sanchi by ABTS assay and FRAP activity  respectively. The study revealed that the leaves of Piper betle (L.) has higher amount of antioxidant activity and it could be used for any novel drug preparation.
PREPARATION AND CHARACTERIZATION OF CHITOSAN NANOPARTICLES OF INSULIN FOR NASAL DELIVERY
Authors: Mishra Subhendu Sekhar , Sharma Ashish
Published: November 2018

The aim of this study was to prepare and evaluate nanoparticles containing insulin in different polymer ratio by ionotropic gelation method. The average particle size was found to be 130.4±3.4 -155.5±6.4nm. SEM indicates that nanoparticles have shown smooth and spherical shape. The zeta potential of optimized formulation was 35.5 mv which indicates moderate stability with no agglomeration. The average drug content was found to be 130.4±3.4 -155.5±6.4nm. The in vitro drug release data was analyzed using zero order, first order, Higuchi, and Korsmeyer-Peppas models. It was observed the best fit model for nanoparticles was higuchi model. The developed formulation in situ polymeric gel is designed in such a way that the gel will load insulin in higher concentration and it will also contain penetration enhancer which will enhance the absorption of release drug from gel to systemic circulation.

Keywords: Insulin, Nanoparticle, invitro drug release study.
Structure of self-schemas in patients with paranoia
Authors: Mihic Ljiljana , Novovic Zdenka , Dozois David , Bentall Richard , Petrovic Tanja
Published: November 2018

Negative self-schemas have been implicated in both paranoia and depression. There is a lack of research on the structural characteristics of self-schemas, even though these characteristics might be stable risk factors. The present study explored organization of positive and negative self-schemas in currently non-depressed individuals with persistent delusional disorder (PD), currently depressed individuals with persistent delusional disorder (PDD), and nonpsychiatric controls (NC). Self-schema consolidation was measured via the Psychological Distance Scaling Task. Within the interpersonal domain, negative selfschemas were more densely organized in PDD compared to both PD and NC. Both patient groups had less interconnected positive interpersonal schemas than controls. Within the achievement domain, PDD demonstrated less consolidated positive achievement schemas than NC and greater interconnectedness among negative adjectives than PD. Central limitation includes a small sample size. The findings point to an existence of at least two self-schema organizations in paranoid individuals.
Effect of Simulated Pulpal Microcirculation on Temperature When Light Curing Bulk Fill Composites
Authors: Braga SSL , Oliveira LRS , Ribeiro MTH , Vilela ABF , da Silva GR , Price RB , Soares CJ
Published: November 2018

Objectives:

To evaluate the effect of light curing bulk fill resin composite restorations on the increase in the temperature of the pulp chamber both with and without a simulated pulpal fluid flow.

Methods and Materials:

Forty extracted human molars received a flat occlusal cavity, leaving approximately 2 mm of dentin over the pulp. The teeth were restored using a self-etch adhesive system (Clearfil SE Bond, Kuraray) and two different bulk fill resin composites: a flowable (SDR, Dentsply) and a regular paste (AURA, SDI) bulk fill. The adhesive was light cured for 20 seconds, SDR was light cured for 20 seconds, and AURA was light cured for 40 seconds using the Bluephase G2 (Ivoclar Vivadent) or the VALO Cordless (Ultradent) in the standard output power mode. The degree of conversion (DC) at the top and bottom of the bulk fill resin composite was assessed using Fourier-Transform Infra Red spectroscopy. The temperature in the pulp chamber when light curing the adhesive system and resin composite was measured using a J-type thermocouple both with and without the presence of a simulated microcirculation of 1.0-1.4 mL/min. Data were analyzed using Student t-tests and two-way and three-way analyses of variance (α=0.05 significance level).

Results:

The irradiance delivered by the light-curing units (LCUs) was greatest close to the top sensor of the MARC resin calibrator (BlueLight Analytics) and lowest after passing through the 4.0 mm of resin composite plus 2.0 mm of dentin. In general, the Bluephase G2 delivered a higher irradiance than did the VALO Cordless. The resin composite, LCU, and region all influenced the degree of cure. The simulated pulpal microcirculation significantly reduced the temperature increase. The greatest temperature rise occurred when the adhesive system was light cured. The Bluephase G2 produced a rise of 6°C, and the VALO Cordless produced a lower temperature change (4°C) when light curing the adhesive system for 20 seconds without pulpal microcirculation. Light curing SDR produced the greatest exothermic reaction.

Conclusions:

Using simulated pulpal microcirculation resulted in lower temperature increases. The flowable composite (SDR) allowed more light transmission and had a higher degree of conversion than did the regular paste (AURA). The greatest temperature rise occurred when light curing the adhesive system alone.
Composite-composite Adhesion as a Function of Adhesive-composite Material and Surface Treatment
Authors: Ritter AV , Sulaiman TA , Altitinchi A , Bair E , Baratto-Filho F , Gonzaga CC , Correr GM
Published: November 2018

Objective:

To evaluate the composite-to-composite repair interfacial fracture toughness (iFT) as a function of adhesive and composite repair material.

Methods and Materials:

Beam-shaped composite specimens (21×4×3±0.2 mm) were prepared for each substrate material (Filtek Supreme Ultra [FSU] or Clearfil Majesty ES-2 [CME]) and artificially aged for 50,000 thermocycles (5-55°C, 20-second dwell time). Aged specimens were sectioned in half, and the resulting hemispecimens were randomly assigned to one of the different repair methods (n=10) based on the following variables: type of substrate composite (FSU or CME), acid etch (yes or no), adhesive type (Scotchbond Universal or Clearfil SE Bond 2), and type of repair composite (FSU or CME). The repair surface was prepared with a course diamond bur (Midwest #471271). When used, 37% phosphoric acid was applied for 20 seconds, rinsed, and dried. All adhesives and composites were applied according to manufacturers' instructions. After postrepair storage (100% humidity, 37°C, 24 hours), iFT was measured and expressed as MPa. Data were analyzed for statistical significance using a three-way analysis of variance and Tukey post hoc tests (α=0.05).

Results:

iFT values ranged from 0.64 ± 0.19 MPa to 1.28 ± 013 MPa. Significantly higher iFT values were achieved when FSU was used as the repair composite resin regardless of the substrate composite resin (p<0.001). Clearfil SE Bond 2 adhesive was associated with significantly higher iFT values for FSU substrate (p<0.001). The etching procedure had no significant effect on the iFT values of the repair procedures (p>0.05).

Conclusions:

Composite repair strength is adhesive and composite dependent. Repair strength appears to be higher when FSU is the repair composite regardless of the adhesive used.
Impact of Modifiable Risk Factors on Bone Loss During Periodontal Maintenance
Authors: Cui X , Monacelli E , Killeen AC , Samson K , Reinhardt RA
Published: November 2018

Objectives:

The aim of this study was to analyze modifiable patient risk factors from dental chart histories and radiographs for progressive mild-moderate periodontitis during periodontal maintenance (PM).

Methods and Materials:

Bitewing radiographs of 442 elderly periodontal maintenance patients were taken before and after two years of periodontal maintenance. Each progressive periodontitis (PP) patient (with at least one site of posterior interproximal bone loss of ≥2 mm, n=71) was matched to a periodontitis stable (PS) patient (no sites with bone loss, n=71) of the same gender and age (±five years) to control for these variables and was compared for measurements of general patient (medical history, smoking, hygiene and compliance habits) and tooth-related (bone loss, overhangs, interproximal dimensions) factors at baseline. Fisher exact and t-tests were used to compare groups.

Results:

While the elderly PM patients with mild-moderate periodontitis were generally stable, 71 of 442 were PP patients. No significant differences from PS patients were observed at baseline with regard to the systemic factors measured. However, the PP group had less cementoenamel junction to bone length (bone loss p<0.0001) and more interproximal width (2.3±1.0 mm) than did the PS group (1.7±0.6 mm, p=0.0016). This was reflected in more open sites without adjacent tooth contact in PP (42% vs 15%, p=0.0006).

Conclusions:

In the short term, systemic and behavior factors are of limited value in identifying mild-moderate periodontitis patients on PM at increased risk of bone loss. However, interproximal width and lack of adjacent tooth contacts are related to the likelihood of losing interproximal bone during periodontal maintenance, suggesting the need for restorative therapy.
LEARNING CONTENT OF ISLAMIC EDUCATION BASED ON MULTIKULTURAL IN SENIOR HIGH SCHOOL IN BANDAR LAMPUNG
Authors: Pahrudin Agus , Syafril Syafrimen , Sada Heru Juabdin
Published: November 2018

The recent multicultural education is being discussed from the various problems that hinder it. In addition to social problems, multicultural education is also not free from problems in the process and learning content. This study aims to describe how Multicultural Content-Based Islamic Educational Content ?, The research is run using a descriptive-qualitative approach (multi-case multi-site). The data were collected through in-depth interviews to two experts of Islamic education and focus group interviews to four teachers who have had work experience of seven to twenty years. Furthermore, the data were analyzed qualitatively using NVIVO 10.0 software. The results of the research show that the content of Islamic-Based Multicultural Education Learning is: Explaining the concept of aqidah and muamalah, Designing material by applying multicultural and emphasizing on equality principle, Making culture as Content, and Rahmatalillalamin Islam concept.
Efektivitas Penerapan Metode Qişşatu Al-Qur`Ānī Untuk Meningkatkan Akhlak Mulia Siswa Kelas IV SD Cirebon Islamic School (CIS) Full Day
Authors: Abdullah Muhammad Luthfi
Published: November 2018

Islamic vision of education is to promote the formation of a noble character of students. In fact, it has not been fully achieved. As evidenced by the mass media that include many adolescents who engage in premarital sex. Beyond the researchers conducted a preliminary study in CIS Elementary School Cirebon. The result is there are still many elementary school fourth graders CIS obligation unworked prayers. It is closely related to a noble character against God. One cause of the lack of success of Islamic Education in schools for vision is the problem of learning methods are monotonous and not touching the psychological aspects of students. As one alternative in solving these problems is the presence of a method that can instill high moral values in students. Quran story method is considered effective in instilling noble moral values to students. Methods story Qur'an have characteristics that are different from other methods. This study aims to determine whether the method Qur'an story has a significant influence on the development of a noble character. Taken population Elementary School fourth grade students of the CIS, with a cluster sampling technique that is in class IV Roudhoh and class IV Multazam. The design was experimental design really. There are two classes, namely the control class and experimental class. Grade control using conventional methods, while the experimental group was treated using the method Qur`an story. Do pretest and posttest for both classes to assess the noble character of students. The hypothesis is that the Quran story method significantly influences the development of the noble character of students. Tests conducted by the independent samples t-test to compute t and t see table at the significance level of 0.05 with NU = 26. The result t is greater than t table (2.18> 1.71). This indicates that the hypothesis is accepted. Thus, the method Qur`an story significant influence on the development of a noble character of students.
Ortak Bilgi Yapılandırma Modelinin Yedinci Sınıf Öğrencilerinin Elektrik Enerjisi Ünitesine İlişkin Kavramsal Anlamalarına Etkisi
Authors: CAYMAZ Belkız , AYDIN Abdullah
Published: November 2018

Bu araştırmanın amacı, Ortak Bilgi Yapılandırma Modeli (OBYM)’ne göre yürütülen fen öğretiminin yedinci sınıf öğ-rencilerinin kavramsal anlamalarına olan etkisini incelemektir. Araştırma, 2016-2017 eğitim-öğretim yılında deney grubunda yer alan 22 ve kontrol grubunda yer alan 20 öğrenci olmak üzere toplam 42 yedinci sınıf öğrencisi ile gerçekleştirilmiştir. Araştırmada, yedinci sınıf elektrik enerjisi ünitesi seçilmiştir ve yarı deneysel yönteme uygun olarak yürütülmüştür. Veri topla-ma aracı olarak, Elektrik Enerjisi Ünitesi Kavramsal Anlama Testi (EEÜKAT) kullanılmıştır. Araştırmadan elde edilen veri-ler, SPSS programı kullanılarak analiz edilmiştir. Konuların OBYM’ne göre işlendiği deney grubu öğrencilerinin EEÜKAT ön-test ve son-test puan ortalamaları arasında son-test lehine anlamlı bir farklılık olduğu bulunmuştur. OBYM’nin öğrencile-rin kavramsal anlamaları üzerinde etkisinin daha net olarak ortaya çıkarılması için fen bilimleri dersinin farklı konularında modelin kullanılmasına yönelik araştırmaların yapılması öneril-mektedir.
An Analysis of Brand Equity Components in the Context of Cultural Festivals
Authors: Seehanam Nawathiwa , Akkaranggoon Supalak , Ungpannsattawung Supanni
Published: November 2018

The objectives of this research are 1) to examine the tourist-based brand equity (TBBE) model for cultural festivals; 2) to analyze the components of brand equity in Loy Krathong Light and Candles Festival at Sukhothai Historical Park in Thailand. In order to verify the validity of the brand equity model for cultural festivals, the conceptual framework of this research was based on the concept of consumer- based brand equity model, namely, brand awareness, brand quality, brand association, brand image, brand loyalty, and brand experience. Questionnaires were used to collect data from 328 Thai tourists, and were analyzed by using the structural equation model. The results showed the correlation between the TBBE model and the empirical data with the significant level of 95. That is to say, brand awareness (BA) has a direct influence on brand quality (BQ) and brand association (BAS). Brand quality (BQ) has a direct influence on brand experience (BEx), and brand experience (BEx) has a direct influence on brand loyalty (BL). This research also found that brand experience (BEx) has an influence on the structure of brand equity for cultural festivals.
Analisis Dan Pemetaan Kesesuaian Lahan Tanaman Anggur Di Kabupaten Buleleng Dengan Sistem Informasi Geografis
Authors: Raharja Made Agung
Published: November 2018

Kabupaten Buleleng ini merupakan salah satu penghasil anggur di Bali yang biasa dikenal dengan julukan Anggur Buleleng. Pengalama beberapa periode sering terjadi buah anggur yang ditanam itu mengalami pembusukan, mati, hingga gagal panen hingga membuat penurunan produktivitas dan membuat para pembudidaya itu mengalami kerugian yang menyebabkan perekonomian daerah melemah. Sehingga digunakan solusi dengan suatu metode atau bantuan teknologi informasi salah satunya adalah dengan Sistem Informasi Geografis. Banyak permasalahan keruangan yang rumit, seperti kependudukan, pertanian, pemetaan wilayah yang menggunakan sistem informasi geografis untuk menyelesaikan masalah. Berdasarkan hasil penelitian dan pengolahan data yang dilakukan mengenai analisis dan perancangan sistem informasi geografis kesesuaian lahan untuk tanaman anggur di Kabupaten Buleleng, maka dapat disimpulkan bahwa : 1) Penelitian ini yaitu menganalisis, merancang, dan mengimplementasikan menggunakan aplikasi QGIS. 2) Persebaran  tanaman  anggur  dikabupaten  Buleleng  mendapatkan  hasil  bahwa  6 kecamatan merupakan kategori S1 yaitu pada kecamatan Gerokgak, Buleleng, Seririt, Banjar, Kubutambahan, dan Tejakula. Jumlah kecamatan yang merupakan kategori S2 (sesuai) adalah sebanyak 2 kecamatan yaitu pada kecamatan Sukasada dan Sawan. Jumlah kecamatan yang merupakan kategori S3 (kurang sesuai) adalah sebanyak 1 kecamatan yaitu pada kecamatan Busungbiu.
Assembly the Semantic Cultural Heritage Knowledge
Authors: Pramartha Cokorda Rai Adi
Published: November 2018

This project aims to assembly the semantic cultural heritage knowledge dealing with one aspect of Balinese heritage, the kulkul system. We discuss our method and procedures to realize the goal of the project. The significant contribution of cultural heritage expert resulted in the kulkul specification and features. Also, the involvement of a knowledgeable community helped us to expand and validate the kulkul ontology. Finally, the cultural heritage knowledge was made available in the form of ontology to represent the knowledge that can be processed and manipulated by the computer program.
Klasifikasi Musik Berdasarkan Genre
Authors: Vida Mastrika Giri Gst Ayu
Published: November 2018

Genre musik adalah salah satu cara yang sangat umum digunakan untuk mengatur database musik digital. Dengan bertambahnya jumlah musik, tentunya pemberian genre secara maual akan membutuhkan banyak tenaga ahli dan waktu yang lama. Saat ini, pemberian genre musik secara otomatis dapat membantu menyelesaikan masalah tersebut. Berbagai teknik klasifikasi dan fitur musik telah digunakan untuk klasifikasi musik berdasarkan genre. Penelitian ini membahas tentang klasifikasi musik berdasarkan genre (classical, EDM, hip-hop, metal, pop, punk, R&B, rap, dan rock) dengan metode K-Nearest Neighbor dengan menggunakan 11 fitur musik (speechiness, energy, danceability, loudness, tempo, mode, valence, instrumentalness, acoustic-ness, dan liveliness). Nilai akurasi klasifikasi pada penelitian ini adalah 44,8%. Nilai tertinggi ada pada genre classical, dengan total akurasi 100% dan nilai terendah ada pada genre pop dengan akurasi 25%.