bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Thiazolidine‐2,4‐diones as Multi‐targeted Scaffold in Medicinal Chemistry: Potential Anticancer Agents
Authors: Asati Vivek , Mahapatra Debarshi Kar , Bharti Sanjay K.
Published: December 2014

Review: 99 refs.
ChemInform Abstract: Biomacromolecules as Novel Green Flame Retardant Systems for Textiles: An Overview
Authors: Malucelli Giulio , Bosco Francesca , Alongi Jenny , Carosio Federico , Di Blasio Alessandro , Mollea Chiara , Cuttica Fabio , Casale Annalisa
Published: December 2014

Review: 86 refs.
ChemInform Abstract: Application of Heteropolyacid‐Based Heterogeneous Catalysts for Conversion of Oleochemicals into Renewable Fuels and Other Value‐Added Products
Authors: Badday Ali Sabri , Abdullah Ahmad Zuhairi , Lee Keat‐Teong
Published: December 2014

Review: 62 refs.
ChemInform Abstract: Reactivity and Mass Transfer of Low‐Dimensional Catalysts
Authors: Weissenrieder Jonas , Gustafson Johan , Stacchiola Dario
Published: December 2014

Review: 86 refs.
ChemInform Abstract: Crystal Structure and Magnetic Ordering Transitions in CeNiIn4, EuNiIn4 and EuCuIn4.
Authors: Schnelle Walter , Kremer Reinhard K. , Hoffmann Rolf‐Dieter , Rodewald Ute Ch. , Poettgen Rainer
Published: December 2014

CeNiIn4 is prepared by arc‐melting of the elements followed by annealing at 970 K for two weeks.
ChemInform Abstract: Double Cube Polycationic Clusters and CuI Between Covalent and Ionic Bonding in Cu(Sb7Te8)[GaCl4]6.
Authors: Eich Andreas , Beck Johannes
Published: December 2014

Single crystals of the title compound are grown by reaction of Sb2Te3 with SbCl3 in a GaCl3‐rich CuGaCl4 melt in presence of Sb2O3 (evacuated glass ampoule, 100 °C, 45 d).
ChemInform Abstract: Synthesis, Structure, and Chemical Bonding in CaCoSi.
Authors: Hoffmann Andrea V. , Hlukhyy Viktor , Faessler Thomas F.
Published: December 2014

The intermetallic title compound is prepared by solid state reaction of the elements (Nb ampule, flowing Ar, 1223 K, 45 min) and characterized by powder and single crystal XRD, magnetic measurements, and TB‐LMTO‐ASA electronic structure calculations.
ChemInform Abstract: One‐Pot Synthesis of Bi24O31Br10/Bi4V2 O11 Heterostructures and Their Photocatalytic Properties.
Authors: Liu ZhangSheng , Niu JiNan , Feng PeiZhong , Sui YanWei , Zhu YaBo
Published: December 2014

The title heterostructures are solvothermally synthesized from ethylene glycol solutions containing Bi(NO3)3, NH4VO3, and cetyltriethylammonium bromide (pH 8 adjusted with aq.
ChemInform Abstract: Synthesis of γ‐Fe2O3/TiO2 Nanocomposite and Its Application in Removal of Dyes from Water Samples by Adsorption and Degradation Processes.
Authors: Madrakian Tayyebeh , Afkhami Abbas , Haryani Reza , Ahmadi Mazaher
Published: December 2014

The title nanocomposite is synthesized from mixtures of SOCl2 and TiO2 nanoparticles (90 °C, 12 h) followed by addition of Et3N and γ‐Fe2O3 nanoparticles (45 °C, 24 h).
ChemInform Abstract: Cube‐in‐Cube Hollow Cu9S5 Nanostructures with Enhanced Photocatalytic Activities in Solar H2 Evolution.
Authors: Xu Miao , Wang Min , Ye Tiannan , Liang Na , Jin Lun , Zai Jiantao , Qian Xuefeng
Published: December 2014

The title nanostructures are hydrothermally prepared by dropwise addition of CS2 into a mixture of aqueous polyvinylpyrrolidone, CuSO4, NaOH, and ascorbic acid (autoclave, 120 °C, 12 h).
ChemInform Abstract: Synthesis and Crystal Structure of Rutile‐Type ScTa2O5N.
Authors: Cosgun Sevilay , Rohloff Martin , Goebel Caren , Gernert Ulrich , Fischer Anna , Lerch Martin
Published: December 2014

The title compound is prepared by oxidizing ammonolysis of an amorphous Sc‐Ta‐O precursor derived by Pechini‐type sol‐gel processing (800 °, 2 h, NH3 and O2 flow rates of 10 and 0.1 l/h, resp., phase purity of 90%).
ChemInform Abstract: Isolated Uranyl Chromate and Polychromate Units in Crown Ether Templated Compounds.
Authors: Siidra Oleg I. , Nazarchuk Evgeny V. , Sysoeva Elena V. , Kayukov Roman A. , Depmeier Wulf
Published: December 2014

Uranyl chromate crown ether systems are used to stabilize and isolate zero‐dimensional units of unprecedented structural architectures.
ChemInform Abstract: Axial Ligands of Ru2 Tuning Zn2+ Rearrangement to Form a New Heterometallic Carbonate: Synthesis, Structure and Magnetic Properties.
Authors: Wu Guang‐Hao , Jin Jin , Jia Yan‐Yan , Yang Jian‐Hui , Liu Bin
Published: December 2014

The new layered heterometallic carbonate ZnHRu2(CO3)4 (H2O)2·2H2O is obtained by self‐assembly from neutral aqueous solutions of K3[Ru2(CO3)4] and Zn(NO3)2 (air, 20 °C, <14 d; 55% yield).
ChemInform Abstract: Asymmetric Michael Addition of α‐Fluoro‐α‐nitroalkanes to Nitroolefins: Facile Preparation of Fluorinated Amines and Tetrahydropyrimidines.
Authors: Kwiatkowski Jacek , Lu Yixin
Published: December 2014

The first synthesis of quaternary stereogenic centers with an α‐fluorine atom and an α‐amino function using an asymmetric Michael reaction of nitroolefins to α‐fluoro‐α‐nitroalkanes is achieved.
ChemInform Abstract: Synthesis of Zirconium Phosphonate Supported L‐Proline as an Effective Organocatalyst for Direct Asymmetric Aldol Addition.
Authors: Angeloni Marco , Piermatti Oriana , Pizzo Ferdinando , Vaccaro Luigi
Published: December 2014

The catalyst is easily recoverable and can be used at least 6 times without any significant loss in activity.
ChemInform Abstract: Pyrazol‐5‐one Diaminomethylidene Derivatives as Reagents for the Synthesis of Heterocyclic Compounds and as New Chelating Ligands.
Authors: Ruban S. V. , Prezent M. A. , Baranin S. V. , Dorokhov V. A.
Published: December 2014

The title compounds (I) are successfully used as N,N‐dinucleophiles in various heterocyclization reactions and the synthesis of diphenylboron chelate (XI).
ChemInform Abstract: A New Recyclable 1,4‐bis(3‐methylimidazolium‐1‐yl)butane Ditribromide [bMImB]·(Br3)2 Ionic Liquid Reagent for Selective Bromination of Anilines or Phenols and α‐Bromination of Alkanones under Mild Conditions.
Authors: Veisi Hojat , Sedrpoushan Alireza , Mohammadi Pourya , Faraji Ali Reza , Sajjadifar Sami
Published: December 2014

A novel ditribromide ionic liquid reagent with high active bromine content, which acts as a good brominating agent is described.
ChemInform Abstract: Allylic sp3 C—H Borylation of Alkenes via Allyl‐Pd Intermediates: An Efficient Route to Allylboronates.
Authors: Deng Hong‐Ping , Eriksson Lars , Szabo Kalman J.
Published: December 2014

A variety of stereodefined homoallylic alcohols are synthesized via a reaction sequence involving allylic C‐H borylation and allylation of aldehydes.
ChemInform Abstract: Direct Synthesis of Arenecarboxamides Through Friedel—Crafts Acylation Using Ureas.
Authors: Ying Wenjiang , Gamage Lalith S. R. , Lovro Luke R. , Herndon James W. III , Jenkins Nathan W. , Herndon James W.
Published: December 2014

Urea derivatives that contain a phenothiazine unit react with electron rich arenes in the presence of triflic anhydride to give the corresponding arenecarboxamides.
ChemInform Abstract: Microwave Assisted Copper Triflate‐Catalyzed Rapid Hydration of Aryl Acetylenes.
Authors: Jha Mukund , Shelke Ganesh M. , Pericherla Kasiviswanadharaju , Kumar Anil
Published: December 2014

The title reaction tolerates a wide range of functional groups and allows the synthesis of acetophenones in short reaction times.
ChemInform Abstract: New in situ Trapping Metalations of Functionalized Arenes and Heteroarenes with TMPLi in the Presence of ZnCl2 and Other Metal Salts.
Authors: Frischmuth Annette , Fernandez Maitane , Barl Nadja M. , Achrainer Florian , Zipse Hendrik , Berionni Guillaume , Mayr Herbert , Karaghiosoff Konstantin , Knochel Paul
Published: December 2014

Lithiation of an aromatic or heteroaromatic substrate is followed by transmetalation under different conditions.
ChemInform Abstract: Continuous Flow Magnesiation of Functionalized Heterocycles and Acrylates with TMPMgCl·LiCl.
Authors: Petersen Trine P. , Becker Matthias R. , Knochel Paul
Published: December 2014

The flow system allows the metallation under conditions which are more convenient than the batch method.
ChemInform Abstract: Efficient Asymmetric Synthesis of N‐Protected‐β‐aryloxyamino Acids via Regioselective Ring Opening of Serine Sulfamidate Carboxylic Acid.
Authors: Malhotra Rajesh , Dey Tushar K. , Dutta Swarup , Basu Sourav , Hajra Saumen
Published: December 2014

In some case the enantiomeric excess is not determined.
ChemInform Abstract: Regiodivergent Kinetic Resolution of Terminal and Internal rac‐Aziridines with Malonates under Dinuclear Schiff Base Catalysis.
Authors: Xu Yingjie , Kaneko Keiichi , Kanai Motomu , Shibasaki Masakatsu , Matsunaga Shigeki
Published: December 2014

Trans‐aziridines do not produce any desired products under the developed conditions.
ChemInform Abstract: Synthesis of New Class of Spirocarbocycle Derivatives by Multicomponent Domino Reaction and Their Evaluation for Antimicrobial, Anticancer Activity and Molecular Docking Studies.
Authors: Sudhapriya N. , Perumal P. T. , Balachandran C. , Ignacimuthu S. , Sangeetha M. , Doble Mukesh
Published: December 2014

A series of 25 new spirocarbocycles such as (IV), (VI), (VIII) is synthesized including three derivatives (VI) and (VIIId) showing good anticancer activities against A549 cancer cell line.
ChemInform Abstract: Sonogashira Cross‐Coupling of 3‐Bromo‐1,2‐diones: An Access to 3‐Alkynyl‐1,2‐diones.
Authors: Paju Anne , Kanger Tonis , Mueuerisepp Aleksander‐Mati , Aid Tiina , Pehk Tonis , Lopp Margus
Published: December 2014

A simple and efficient Sonogashira cross‐coupling reaction of cyclic 3‐bromo‐1,2‐diketones with substituted acetylenes is developed.
ChemInform Abstract: Asymmetric Henry Reaction Catalyzed by a Chiral Dinuclear Nickel Complex.
Authors: Liu Yajun , Deng Ping , Li Xiangyang , Xiong Yan , Zhou Hui
Published: December 2014

The synthesis of the ligand is described as well as the preparation of three derivatives thereof all providing significantly lower yields and enantioselectivities.
ChemInform Abstract: Direct Enantioselective Three‐Component Synthesis of Optically Active Propargylamines in Water.
Authors: Ohara Mutsuyo , Hara Yoshichika , Ohnuki Tohru , Nakamura Shuichi
Published: December 2014

SDS and the Cu‐catalyst with a hydrophobic substituent are optimal for the process.
ChemInform Abstract: Active Pd/Fe(OH)x Catalyst Preparation for Nitrobenzene Hydrogenation by Tracing Aqueous Phase Chlorine Concentrations in the Washing Step of Catalyst Precursors.
Authors: Zhang Chengming , Cui Xinjiang , Deng Youquan , Shi Feng
Published: December 2014

The catalyst is recycled by simple centrifugation, but its reuse proceeds with decreased activity.
ChemInform Abstract: Highly Stereoselective anti‐Markovnikov Hydrothiolation of Alkynes and Electron‐Deficient Alkenes by a Supported Cu‐NHC Complex.
Authors: Yang Yong , Rioux Robert M.
Published: December 2014

The recyclable and efficient heterogeneous catalyst tolerates a broad substrate scope and exhibits higher activity and product stereoselectivity to Z‐vinyl sulfides than its homogeneous analog.
ChemInform Abstract: Transition‐Metal‐Free Synthesis of Vinyl Sulfones via Tandem Cross‐Decarboxylative/Coupling Reactions of Sodium Sulfinates and Cinnamic Acids.
Authors: Xu Yanli , Tang Xiaodong , Hu Weigao , Wu Wanqing , Jiang Huanfeng
Published: December 2014

It is proposed that the reaction is started by the oxidation of sulfinate by DMSO to form a sulfonyl radical.
ChemInform Abstract: Chemoselective Arylation of Phenols with Bromo‐nitroarenes: Synthesis of Nitro‐biaryl‐ols and Their Conversion into Benzofurans and Carbazoles.
Authors: Kumar Amit , Yadav Abhimanyu , Verma Ajay , Jana Sadhan , Sattar Moh. , Kumar Shailesh , Prasad Ch. Durga , Kumar Sangit
Published: December 2014

A mild method is developed for the construction of the title compounds tolerating diverse functional groups.
ChemInform Abstract: Copper‐Catalyzed Cross‐Coupling of Aryl‐ and Heteroaryltriethoxysilanes with Aryl and Heteroaryl Iodides and Bromides.
Authors: Gurung Santosh K. , Thapa Surendra , Shrestha Bijay , Giri Ramesh
Published: December 2014

The title transformation proceeds with activated aryl iodides or bromides, in the latter case requiring a stoichiometric amount of the catalyst for best product yields [cf.
ChemInform Abstract: (BeDABCO)2Pd2Cl6 as an Efficient Homogeneous Catalyst for Copper‐Free Sonogashira Cross‐Coupling Reaction.
Authors: Hajipour Abdol R. , Rafiee Fatemeh
Published: December 2014

The stable homogeneous catalytic system is nonsensitive to air and moisture.
ChemInform Abstract: An Expedient One‐Pot Sequential Three‐Component Reaction for the Stereoselective Synthesis of Functionalized Spiro‐Sulfamidate Imine Fused δ‐Lactone Scaffold.
Authors: Majee Debashis , Biswas Soumen , Mobin Shaikh M. , Samanta Sampak
Published: December 2014

A Michael‐condensation/hemiacetalization/oxidation sequence is developed for the diastereoselective synthesis of the title spiro compounds from oxathiazoledioxides, acroleins, and paraformaldehyde.
ChemInform Abstract: Carbonylative Enantioselective meso‐Desymmetrization of cis‐Epoxides to trans‐β‐Lactones: Effect of Salen‐Ligand Electronic Variation on Enantioselectivity.
Authors: Mulzer Michael , Lamb Jessica R. , Nelson Zachary , Coates Geoffrey W.
Published: December 2014

Several salen alumina complexes are tested in the carbonylation reaction of alkyl epoxides.
ChemInform Abstract: Access to Novel Functionalized Trifluoromethyl β‐Lactams by Ring Expansion of Aziridines.
Authors: Decamps S. , Sevaille L. , Ongeri S. , Crousse B.
Published: December 2014

β‐bromo lactams are prepared highly diastereoselectively by aziridine ring expansion and are applied in radical and nucleophilic reactions.
ChemInform Abstract: Decarboxylative Knoevenagel‐Type Reactions on Tetronamides: Synthesis of 5‐Ylidene‐4‐Amino‐2(5H)‐Furanones.
Authors: Ear Alexandre , Toum Valerie , Thorimbert Serge , Dechoux Luc
Published: December 2014

Transformation of 2,2‐dimethoxyacetaldehyde, ethyl 3‐oxopropanoate or pentan‐3‐one does not lead to the desired products.
ChemInform Abstract: Scalable, Transition‐Metal‐Free Direct Oxime O‐Arylation: Rapid Access to O‐Arylhydroxylamines and Substituted Benzo[b]furans.
Authors: Gao Hongyin , Xu Qing‐Long , Keene Craig , Kuerti Laszlo
Published: December 2014

A broad spectrum of O‐aryloximes is readily available on treatment of inexpensive oximes with symmetrical diaryliodonium salts in the absence of a transition metal.
ChemInform Abstract: Arylation and Heteroarylation of Thienylsulfonamides with Organotrifluoroborates.
Authors: Noreen Mnaza , Rasool Nasir , El Khatib Mirna , Molander Gary A.
Published: December 2014

A diverse range of NH2‐unsubstituted thienylsulfonamides is conveniently prepared by a mild and practical Suzuki cross‐coupling protocol uses the thienyl bromide (I) and aromatic, aliphatic, and heteroaromatic air‐ and benchstable trifluoroborates.
ChemInform Abstract: N,N′‐Dibenzosuberyl‐1,1′‐binaphthyl‐2,2′‐diamine: A Highly Effective Supporting Ligand for the Enantioselective Cyclization of Aminoalkenes Catalyzed by Chelating Diamide Complexes of La(III) and Y(III).
Authors: Huynh Khoi , Livinghouse Tom , Lovick Helena M.
Published: December 2014

Ytterbium, scandium and lutetium analogues of the catalysts require longer reaction times and provide the corresponding products with lower yields and enantiomeric purity.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Reductive Cross‐Coupling of Csp2—Csp3 Bond Formation.
Authors: Liu Hui , Wei Jianpeng , Qiao Zongjun , Fu Yana , Jiang Xuefeng
Published: December 2014

An efficient Pd‐catalyzed reductive intramolecular cross‐coupling of bis‐iodo substrates of type (I) is developed to give good yields of indolines (II).
ChemInform Abstract: Catalytic Functionalization of Indoles by Copper‐Mediated Carbene Transfer.
Authors: Delgado‐Rebollo Manuela , Prieto Auxiliadora , Perez Pedro J.
Published: December 2014

After the first step a cyclopropane intermediate is obtained which is directly converted to indole derivatives (III), (VI), (VII), and (IX) after silica gel column chromatography.
ChemInform Abstract: Facile Regiospecific Synthesis of 2,3‐Disubstituted Indoles from Isatins.
Authors: Dou Xiaowei , Yao Weijun , Wen Shan , Lu Yixin
Published: December 2014

A novel and very simple regiospecific synthesis of 2,3‐disubstituted indoles from isatins is developed.
ChemInform Abstract: Asymmetric Synthesis of Isoindolones by Chiral Cyclopentadienyl‐Rhodium(III)‐Catalyzed C—H Functionalizations.
Authors: Ye Baihua , Cramer Nicolai
Published: December 2014

Diazo compounds are used as one‐carbon component in the reaction with arylhydroxamates.
ChemInform Abstract: An Unexpected Inversion of Enantioselectivity in a Copper‐Catalyzed Intramolecular Desymmetric Aryl C—N Coupling Reaction.
Authors: Liu Jiangguang , Yan Jiajie , Qin Dongguang , Cai Qian
Published: December 2014

Both enantiomeric products are obtained using the same catalyst but in the presence or absence of DMAP as an additive.
ChemInform Abstract: Multicomponent Synthesis and Biological Activity of (Sulfanylalkyl)‐Substituted Azaheterocycles.
Authors: Akhmetova V. R. , Akhmadiev N. S. , Meshcheryakova E. S. , Khalilov L. M. , Ibragimov A. G.
Published: December 2014

Multicomponent reaction of acetylacetone with formaldehyde and S‐nucleophiles followed by in situ reaction of bisdiketone intermediates formed [cf.
ChemInform Abstract: Synthesis and N‐Functionalization of Isoxazolidines: A New Approach to Nucleoside Analogues.
Authors: Sousa Carlos A. D. , Rodriguez‐Borges Jose E. , Garcia‐Mera Xerardo
Published: December 2014

1,3‐Cycloaddition reactions between methyl glyoxylate oxime and alkenes in the presence of BF3·OEt2 provides isoxazolidines.
ChemInform Abstract: Direct Assembly of 2‐Oxazolidinones by Chemical Fixation of Carbon Dioxide.
Authors: Niemi Teemu , Perea‐Buceta Jesus E. , Fernandez Israel , Alakurtti Sami , Rantala Erika , Repo Timo
Published: December 2014

β‐ and γ‐Haloamines react readily in the presence of a base and the absence of any catalyst to produce the desired heterocycles as synthons of antibiotics.
ChemInform Abstract: Copper‐Catalyzed Annulation of Heteroaromatic β‐Halo‐α,β‐unsaturated Carboxylic Acids with Alkynes for the Synthesis of Indolo[2,3‐c]pyrane‐1‐ones and Thieno[2,3‐c]pyrane‐7‐ones.
Authors: Gu Da‐Wei , Guo Xun‐Xiang
Published: December 2014

This strategy offers a simple and efficient route for the synthesis of the title compounds with good tolerance for a variety of functional groups from easily available heteroaromatic carboxylic acids in the presence of Cu(OAc)2,·H2O as catalyst.
ChemInform Abstract: Expeditious Photochemical Reaction Toward the Preparation of Substituted Chroman‐4‐ones.
Authors: Iguchi Daniela , Erra‐Balsells Rosa , Bonesi Sergio M.
Published: December 2014

The facile protocol allows the conversion of aryl esters (I) and (III) into chroman‐4‐ones via sequential photo‐Fries rearrangement and intramolecular oxa‐Michael addition.
ChemInform Abstract: Palladium‐Catalyzed Oxidative CH/CH Cross‐Coupling of Pyridine N‐Oxides with Five‐Membered Heterocycles.
Authors: Liu Wei , Yu Xin , Li Yahui , Kuang Chunxiang
Published: December 2014

A series of 2‐heteroaryl‐substituted pyridine N‐oxides (III) is prepared by palladium‐catalyzed oxidative cross‐coupling of N‐oxides (I) with corresponding heteroarenes (26 examples).
ChemInform Abstract: One‐Pot Pseudo Three‐Component Reaction of Nitroketene‐N,S‐acetals and Aldehydes for Synthesis of Highly Functionalized Hexa‐Substituted 1,4‐Dihydropyridines.
Authors: Rao H. Surya Prakash , Parthiban A.
Published: December 2014

A new regio‐ and chemoselective, high‐yielding and experimentally convenient one‐pot synthesis of diversely functionalized dihydropyridines from readily available aldehydes and nitroketene‐N,S‐acetals is described using 2‐aminopyridine as catalyst.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Hydrogenation of 3‐Phthalimido Substituted Quinolines.
Authors: Cai Xian‐Feng , Huang Wen‐Xue , Chen Zhang‐Pei , Zhou Yong‐Gui
Published: December 2014

The first example of homogeneous palladium‐catalyzed asymmetric hydrogenation of substituted quinolines is described.
ChemInform Abstract: La2O3/TFE: An Efficient System for Room Temperature Synthesis of Hantzsch Polyhydroquinolines.
Authors: Tekale Sunil U. , Pagore Vijay P. , Kauthale Sushama S. , Pawar Rajendra P.
Published: December 2014

The employed catalyst can be recycled and reused up to three times without significant loss of its activity.
ChemInform Abstract: A New and Practical Synthesis of 7‐(3‐Chloropropoxy)‐6‐methoxy‐4‐oxo‐1,4‐dihydroquinoline‐3‐carbonitrile (IV).
Authors: Wang Han , Mao Yongjun , Qin Jianfeng , He Haijun , Liu Gang , Gao Bingyi
Published: December 2014

Bosutinib intermediate (IV) is synthesized on a hectogram scale in 98.6 % purity.
ChemInform Abstract: Nano Fe3O4 Supported Biimidazole Cu(I) Complex as a Retrievable Catalyst for the Synthesis of Imidazo[1,2‐a]pyridines in Aqueous Medium.
Authors: Tajbakhsh Mahmood , Farhang Maryam , Hosseinzadeh Rahman , Sarrafi Yaghoub
Published: December 2014

The title nanocatalyst is successfully employed for the synthesis of imidazopyridines in aqueous medium via three‐component reaction of 2‐aminopyridine, aldehydes, and phenylacetylene.
ChemInform Abstract: Synthesis of 2‐Substituted Pyrimidines and Benzoxazoles via a Visible‐Light‐Driven Organocatalytic Aerobic Oxidation: Enhancement of the Reaction Rate and Selectivity by a Base.
Authors: Wang Lin , Ma Zhi‐Gang , Wei Xiao‐Jing , Meng Qing‐Yuan , Yang Deng‐Tao , Du Shao‐Fu , Chen Zi‐Fei , Wu Li‐Zhu , Liu Qiang
Published: December 2014

The reaction proceeds through a significant enhanced photo‐induced electron transfer from the starting material to the excited state of TBA‐eosin Y (TEY) with aid of the base.
ChemInform Abstract: Facile Synthesis and Antitumor Activity of Novel 2‐Trifluoromethylthieno[2,3‐d]pyrimidine Derivatives.
Authors: Song Xin‐Jian , Yang Ping , Gao Hui , Wang Yan , Dong Xing‐Gao , Tan Xiao‐Hong
Published: December 2014

The title compounds (VII) (11 examples) are synthesized by a facile three‐step procedure, which exhibits several advantages such as mild reaction conditions, simple protocol and good yields.
ChemInform Abstract: Palladium Catalyzed Synthesis and Physical Properties of Indolo[2,3‐b]quinoxalines.
Authors: Hung Tran Quang , Hoang Do Huy , Thang Ngo Ngoc , Dang Tuan Thanh , Ayub Khurshid , Villinger Alexander , Friedrich Aleksej , Lochbrunner Stefan , Flechsig Gerd‐Uwe , Langer Peter
Published: December 2014

Two strategies for the preparation of the title compounds are reported.
ChemInform Abstract: Preparation and Regioselective Metalation of Bis(trimethylsilyl)methyl‐Substituted Aryl Derivatives.
Authors: Werner Veronika , Klatt Thomas , Fujii Masaya , Markiewicz Jenifer , Apeloig Yitzhak , Knochel Paul
Published: December 2014

Kumada—Corriu cross‐coupling reaction of aryl bromides with Grignard reagent (II) provides bis(trimethlsilyl)methyl substituted aryl compounds (III).
ChemInform Abstract: Metal and Base‐Free Synthesis of Arylselanyl Anilines Using Glycerol as a Solvent.
Authors: Thurow S. , Penteado F. , Perin G. , Jacob R. G. , Alves D. , Lenardao E. J.
Published: December 2014

The reaction is conducted under environmentally benign conditions, using the non‐toxic, low volatile, renewable glycerol as solvent.
ChemInform Abstract: A New Germacrane‐Type Sesquiterpene from Fermented Curcuma longa L.
Authors: Quang Tran Hong , Lee Dong‐Sung , Kim Yonhjae , Oh Hyuncheol , Baek Humyoung , Kim Youn‐Chul
Published: December 2014

isolation and structure elucidation of a new sesquiterpene, longanone A (I), showing nitrite inhibitory effects
ChemInform Abstract: Eucalmaidials A and B, Phloroglucinol‐Coupled Sesquiterpenoids from the Juvenile Leaves of Eucalyptus maideni.
Authors: Tian Li‐Wen , Xu Min , Li Xing‐Cong , Yang Chong‐Ren , Zhu Hua‐Jie , Zhang Ying‐Jun
Published: December 2014

Eucalmaidial A (I) exhibits antifungal activity against Candida glabrata.
ChemInform Abstract: Clerodane Diterpenes from Polyalthia longifolia var. pendula Protect SK‐N‐MC Human Neuroblastoma Cells from β‐Amyloid Insult.
Authors: Wu Yang‐Chang , et al. et al.
Published: December 2014

The three new diterpenes, polylongifoliaic A (I) and polylongifoliaons A (II), are isolated together with nine known diterpenes.
ChemInform Abstract: A Three‐Step Synthesis of the Guaianolide Ring System.
Authors: Hullaert Jan , Laplace Duchan R. , Winne Johan M.
Published: December 2014

The tricyclic sesquiterpene ring system is constructed by Ga(OTf)3‐catalyzed cycloaddition.
ChemInform Abstract: Bioactive 9,11‐Secosteroids from Gorgonian Subergorgia suberosa Collected from the South China Sea
Authors: Liu Min , Shao Chang‐Lun , Chen Min , Qi Jun , Wang Yu , Fang Yu‐Chun , Wang Chang‐Yun
Published: December 2014

isolation, structure and cytotoxicity of five new secosteroids (I) and seven known analogues
ChemInform Abstract: Cyanogramide with a New Spiro[indolinone‐pyrroloimidazole] Skeleton from Actinoalloteichus cyanogriseus.
Authors: Fu Peng , Kong Fandong , Li Xia , Wang Yi , Zhu Weiming
Published: December 2014

The alkaloid cyanogramide (I) is isolated from Actinoalloteichus cyanogriseus.
ChemInform Abstract: Total Synthesis of Enantiopure Potassium Aeshynomate.
Authors: Rizos Stergios R. , Stefanakis John G. , Kotoulas Stefanos S. , Koumbis Alexandros E.
Published: December 2014

The synthesis of title compound (I) (initially starting from D‐arabinose), the leaf‐opening factor of the nyctinastic plant Aeshynomene indica L., allows the determination of its absolute configuration.
ChemInform Abstract: First Total Synthesis and Reassignment of Absolute Configuration of Diosniponol A and B.
Authors: Yadav J. S. , Singh Vinay K. , Thirupathaiah B. , Reddy A. Bal
Published: December 2014

The first enantioselective synthesis of the proposed structures of diosniponol A and B from vanillin via Wittig reaction, Keck allylation, and Prins cyclization is described.
ChemInform Abstract: Synthesis and Near‐Infrared Luminescence of La3GaGe5O16:Cr3+ Phosphors.
Authors: Zhou Jun , Xia Zhiguo
Published: December 2014

The new title phosphor is synthesized by solid state reaction of La2O3, Ga2O3, GeO2, and Cr2O3 (alumina crucible, 1250 °C, 5 h in air).
ChemInform Abstract: Oxygen Electrocatalysts in Metal—Air Batteries: From Aqueous to Nonaqueous Electrolytes
Authors: Wang Zhong‐Li , Xu Dan , Xu Ji‐Jing , Zhang Xin‐Bo
Published: December 2014

Review: 416 refs.
ChemInform Abstract: Electric Field Control of Magnetism Using BiFeO3‐Based Heterostructures
Authors: Heron J. T. , Schlom D. G. , Ramesh R.
Published: December 2014

Review: 106 refs.
ChemInform Abstract: The Lengths of the Metal‐to‐Metal Quintuple Bonds and Reactivity Thereof
Authors: Nair Anokh K. , Harisomayajula N. V. Satyachand , Tsai Yi‐Chou
Published: December 2014

Review: 87 refs.
ChemInform Abstract: Ruthenium II Complexes Bearing Fused Polycyclic Ligands: from Fundamental Aspects to Potential Applications
Authors: Troian‐Gautier Ludovic , Moucheron Cecile
Published: December 2014

Review: 217 refs.
ChemInform Abstract: Dimolybdenum Dimers Spaced by Phenylene Groups: The Experimental Models for Study of Electronic Coupling
Authors: Lei Hao , Xiao Xuan , Meng Miao , Cheng Tao , Shu Yao , Tan Ying Ning , Liu Chun Y.
Published: December 2014

Review: 68 refs.
ChemInform Abstract: Isoquinoline Skeleton Synthesis via Chelation‐Assisted C—H Activation
Authors: He Ruoyu , Huang Zhi‐Tang , Zheng Qi‐Yu , Wang Congyang
Published: December 2014

Review: [27 refs.
ChemInform Abstract: Part 1. Nitroalkenes in the Synthesis of Heterocyclic Compounds
Authors: Halimehjani Azim Ziyaei , Namboothiri Irishi N. N. , Hooshmand Seyyed Emad
Published: December 2014

Review: [266 refs.
ChemInform Abstract: Aspergillomarasmine A, an Inhibitor of Bacterial Metallo‐β‐Lactamases Conferring blaNDM and blaVIM Resistance
Authors: von Nussbaum Franz , Schiffer Guido
Published: December 2014

Review: 16 refs.
ChemInform Abstract: Molecular Artificial Photosynthesis
Authors: Berardi Serena , Drouet Samuel , Francas Laia , Gimbert‐Surinach Carolina , Guttentag Miguel , Richmond Craig , Stoll Thibaut , Llobet Antoni
Published: December 2014

Review: 50 refs.
ChemInform Abstract: 2‐Alkynylbenzaldoxime: A Versatile Building Block for the Generation of N‐Heterocycles
Authors: He Linman , Nie Hongming , Qiu Guanyinsheng , Gao Yueqiu , Wu Jie
Published: December 2014

Review: [33 refs.
ChemInform Abstract: The Use of the Sterically Demanding IPr* and Related Ligands in Catalysis
Authors: Izquierdo Frederic , Manzini Simone , Nolan Steven P.
Published: December 2014

Review: 74 refs.
ChemInform Abstract: Hydroaminoalkylation: Early‐Transition‐Metal‐Catalyzed α‐Alkylation of Amines
Authors: Chong Eugene , Garcia Pierre , Schafer Laurel L.
Published: December 2014

Review: [38 refs.
ChemInform Abstract: Gold Catalyzed Chemo‐ and Site‐Selective Direct C‐H Functionalization of Phenols with Diazo Compounds
Authors: Wang Jianbo
Published: December 2014

Review: 1 refs.
ChemInform Abstract: Bifunctional Catalyst Control of Alkene Isomerization
Authors: Grotjahn Douglas B. , Larsen Casey R. , Erdogan Gulin
Published: December 2014

Review: 69 refs.
ChemInform Abstract: Organic Chemistry Reactivity Tamed One Bond at a Time
Authors: Villaume Matthew T. , Baran Phil S.
Published: December 2014

Review: 8 refs.
ChemInform Abstract: Chopping Unfunctionalized Carbon—Carbon Bonds: a New Paradigm for the Synthesis of Organonitriles
Authors: Bisseret Philippe , Duret Guillaume , Blanchard Nicolas
Published: December 2014

Review: 54 refs.
ChemInform Abstract: Amino Acidic Scaffolds Bearing Unnatural Side Chains: An Old Idea Generates New and Versatile Tools for the Life Sciences
Authors: Stevenazzi Andrea , Marchini Mattia , Sandrone Giovanni , Vergani Barbara , Lattanzio Maria
Published: December 2014

Review: 54 refs.
ChemInform Abstract: Metal‐Catalyzed Nitrile Hydration Reactions: The Specific Contribution of Ruthenium
Authors: Garcia‐Alvarez Rocio , Francos Javier , Tomas‐Mendivil Eder , Crochet Pascale , Cadierno Victorio
Published: December 2014

Review: 160 refs.
ChemInform Abstract: Heterogeneous Tin Catalysts Applied to the Esterification and Transesterification Reactions
Authors: da Silva Marcio Jose , Cardoso Abiney Lemos
Published: December 2014

Review: 36 refs.
ChemInform Abstract: Synergistic Catalysis by Multifunctionalized Solid Surfaces for Nucleophilic Addition Reactions
Authors: Motokura Ken
Published: December 2014

Review: 57 refs.
ChemInform Abstract: Organophosphorus Chemistry
Authors: Hanson Paul R.
Published: December 2014

Review: highlights and details of some novel methods that are advancing the field of oganophosphorus chemistry
ChemInform Abstract: Application of Butane‐2,3‐diacetals in the Synthesis of Optically Active Natural Products
Authors: Waclawczyk‐Biedron Weronika , Drop Adam , Frackowiak‐Wojtasek Bozena
Published: December 2014

Review: 29 refs.
ChemInform Abstract: Ionic Liquids: the Synergistic Catalytic Effect in the Synthesis of Cyclic Carbonates
Authors: Cheng Weiguo , Su Qian , Wang Jinquan , Sun Jian , Ng Flora T. T.
Published: December 2014

Review: 105 refs.
ChemInform Abstract: Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis
Authors: Pratap Ramendra , Ram Vishnu Ji
Published: December 2014

Review: 438 refs.
ChemInform Abstract: Understanding the Electron‐Stimulated Surface Reactions of Organometallic Complexes to Enable Design of Precursors for Electron Beam‐Induced Deposition
Authors: Spencer Julie A. , Rosenberg Samantha G. , Barclay Michael , Wu Yung‐Chien , McElwee‐White Lisa , Howard Fairbrother D.
Published: December 2014

Review: 77 refs.
ChemInform Abstract: Recent Advances in the Discovery of N‐Myristoyltransferase Inhibitors
Authors: Zhao Can , Ma Shutao
Published: December 2014

Review: [with particular focus on their activities, structure—activity relationships, and mechanisms; 74 refs.
ChemInform Abstract: The Mechanical Role of Metal Ions in Biogenic Protein‐Based Materials
Authors: Degtyar Elena , Harrington Matthew J. , Politi Yael , Fratzl Peter
Published: December 2014

Review: recent advances in the understanding of biological structure‐function relationships; 187 refs.
ChemInform Abstract: Mechanical Pretreatments of Lignocellulosic Biomass: Towards Facile and Environmentally Sound Technologies for Biofuels Production
Authors: Barakat Abdellatif , Mayer‐Laigle Claire , Solhy Abderrahim , Arancon Rick A. D. , de Vries Hugo , Luque Rafael
Published: December 2014

Review: 81 refs.
ChemInform Abstract: Advances in Anion Supramolecular Chemistry: From Recognition to Chemical Applications
Authors: Evans Nicholas H. , Beer Paul D.
Published: December 2014

Review: [255 refs.
ChemInform Abstract: Catalytic Fast Pyrolysis of Lignocellulosic Biomass
Authors: Liu Changjun , Wang Huamin , Karim Ayman M. , Sun Junming , Wang Yong
Published: December 2014

Review: 354 refs.
ChemInform Abstract: Heterogeneous Catalysis for Sustainable Biodiesel Production via Esterification and Transesterification
Authors: Lee Adam F. , Bennett James A. , Manayil Jinesh C. , Wilson Karen
Published: December 2014

Review: 273 refs.
ChemInform Abstract: New Advances in the Use of Infrared Absorption Spectroscopy for the Characterization of Heterogeneous Catalytic Reactions
Authors: Zaera Francisco
Published: December 2014

Review: 511 refs.
Interpretation of p16INK4a/Ki‐67 dual immunostaining for the triage of human papillomavirus‐positive women by experts and nonexperts in cervical cytology
Authors: Allia Elena , Ronco Guglielmo , Coccia Anna , Luparia Patrizia , Macrì Luigia , Fiorito Corinna , Maletta Francesca , Deambrogio Cristina , Tunesi Sara , De Marco Laura , Gillio‐Tos Anna , Sapino Anna , Ghiringhello Bruno
Published: December 2014

BACKGROUND

The triage of human papillomavirus (HPV)‐positive women is needed to avoid overreferral to colposcopy. p16INK4a immunostaining is an efficient triage method. p16INK4a/Ki‐67 dual staining was introduced mainly to increase reproducibility and specificity compared with stand‐alone p16INK4a staining.

METHODS

Within a pilot project, HPV‐positive women were referred to colposcopy if cytology was abnormal or unsatisfactory or HPV testing was still positive after 1 year. For 500 consecutive women, a slide obtained during colposcopy was immunostained for p16INK4a/Ki‐67 and independently interpreted by 7 readers without previous experience with dual staining. Four of these readers were experts in cervical pathology and 3 were not. Kappa values for multiple raters, sensitivity, and specificity for cervical intraepithelial neoplasia type 2‐positive histology were computed. Because women with normal cytology were underrepresented, estimates for all HPV‐positive women were obtained as weighted means of cytology‐specific estimates.

RESULTS

The overall kappa for HPV‐positive women was 0.70 (95% confidence interval [95% CI], 0.60‐0.77). Kappa values were not found to be significantly different between expert and nonexpert readers with regard to cervical cytology but were significantly increased (P =. 0066) after consensus discussion. The overall specificity estimate for HPV‐positive women was 64.0% (95% CI, 57.4%‐70.2%): 66.7% (95% CI, 59.8%‐73.0%) for experts and 60.5% (95% CI, 59.8%‐73.0%) for nonexperts. Among women with abnormal cytology, the sensitivity was 85.5% (95% CI, 77.9%‐90.8%): 85.8% (95% CI, 77.9%‐91.2%) for experts and 85.1% (95% CI, 76.6%‐90.9%) for nonexperts.

CONCLUSIONS

p16INK4a/Ki‐67 immunostaining demonstrated good reproducibility and specificity when triaging HPV‐positive women. Dual‐staining interpretation can be performed, after short training, even by staff who are not experts in cervical cytology. This allows HPV‐based screening with triage to be performed in settings in which such expert staff is not available. Cancer (Cancer Cytopathol) 2015;123:212–218. © 2014 American Cancer Society.
Controlling the Reactivity of the SeSe Bond by the Supramolecular Chemistry of Cucurbituril
Authors: Ren Huifeng , Huang Zehuan , Yang Hui , Xu Huaping , Zhang Xi
Published: December 2014

We describe a new strategy to control the reactivity of SeSe bond by using supramolecular chemistry of cucurbituril. We have demonstrated that selenocystamine (SeCy) and cucurbit[6]uril (CB[6]) can form a stable supramolecular complex (Ka=5.5×106 M−1). Before complexation, the free SeSe bond in SeCy is rather sensitive to redox stimuli and gets disrupted quickly with addition of reductant or oxidant. However, after binding with CB[6], the SeSe bond becomes quite inert and hardly reacts with reductant or oxidant. One advantage of this supramolecular protection is that it can be applied in a wide pH range from weakly acidic to basic. Additionally, the supramolecular complex formed by SeCy and CB[6] can be reversibly dissociated simply with addition of Ba2+.
β‐Ionic Conjugated Chlorin‐Type Photosensitizers Based on Porpholactone: Synthesis, Photophysical Properties, and Photodynamic Activity
Authors: Ke Xian‐Sheng , Tang Juan , Chen Juan‐Juan , Zhou Zheng‐Yang , Zhang Jun‐Long
Published: December 2014

Porpholactones and their derivatives have attracted increasing attention for their promising application as photosensitizers. Reduction of the β‐lactone moiety in porpholactone to β‐hemiacetal, named porpholactol, allows the synthesis of chlorin‐type photosensitizers with enhanced near‐infrared absorption as well as β functionalization of water‐soluble conjugates. By employing β‐hydrophilic conjugates terminated by different ionic groups, such as neutral (ZnL1), anionic (ZnL2), zwitterionic (ZnL3), and cationic (ZnL4–6) groups, a series of photosensitizers (ZnL1–6) were synthesized and characterized, and their photophysical properties were studied, including magnetic circular dichroism measurement. The terminal ionic groups on β conjugates influence significantly the cellular uptake of ZnL1–6 in the order ZnL4–6 (positive charge)>ZnL1–3 (negative charge or neutral). Importantly, the photocytotoxicity of ZnL1–6 against cancer cells showed IC50 values down to the sub‐micromolar range and exhibited the same trend as their cellular uptake, clearly revealing the relationship of β‐ionic conjugates, cellular uptake, and intracellular photodynamic therapy (PDT) activity. Furthermore, using ZnL4 as an example, mechanistic studies, such as cell imaging experiments and Western blot analysis for the PDT process, indicate that ZnL4 exerts photodynamic activity through apoptosis, which is highly associated with lysosome disruption, mitochondria depolarization, and nuclei condensation.
Organoruthenium and Osmium Anticancer Complexes Bearing a Maleimide Functional Group: Reactivity to Cysteine, Stability, and Cytotoxicity
Authors: Moon Sally , Hanif Muhammad , Kubanik Mario , Holtkamp Hannah , Söhnel Tilo , Jamieson Stephen M. F. , Hartinger Christian G.
Published: December 2014

Targeted delivery provides a means to overcome the systemic toxicity of cancer chemotherapeutics. Maleimide functionalization of anticancer‐active metal complexes allows their site‐selective covalent conjugation to human serum albumin (HSA) to exploit passive targeting to the tumor site through the enhanced permeability and retention (EPR) effect. By incorporating the maleimide moiety in the monodentate N‐donor coligands, a series of [MII(cym)X2] (M=Ru, Os; cym=η6‐p‐cymene; X=Cl2, Br2, I2, oxalate) complexes was synthesized and characterized. The influence of the metal center, η6‐arene, and leaving group X on the chemical and biological properties was studied. The compounds exhibited low stability in dimethyl sulfoxide (DMSO) but were more stable in the 5 % aqueous DMSO solution used in biological assays. Incubation with cysteine as a model for thiol‐containing biomolecules demonstrated high reactivity of the maleimide with the thiol group. In in vitro anticancer assays in human colorectal, non‐small‐cell lung, and cervical carcinoma cells the complexes were good to moderately active with the lowest IC50 value at 8 μM for an osmium–iodido complex.
Be mindful of students' experience to better serve them
Authors: Gomez Cynthia
Published: December 2014

Jenna Walraven is an ethics and compliance program manager at Apollo Education Group. In that role, she oversees compliance with the Americans with Disabilities Act, the Clery Act, and the Drug‐Free Workplace Act for the University of Phoenix and Western International University. She's also the newest member of Disability Compliance for Higher Education's Board of Advisors.
Develop key qualities to become a more effective supervisor
Authors: McCarthy Claudine
Published: December 2014

Departmental administrators are often expected to supervise other staff members. And although they're eager to become effective supervisors, most receive little to no training in supervision skills. So they often end up supervising the way they were supervised, for better or worse. That's according to Sarah Marshall, an associate professor in the Department of Educational Leadership at Central Michigan University.
Prepare students with hearing impairments for world of work
Authors: Gomez Cynthia
Published: December 2014

Students with hearing impairments may get discouraged by the prospect of being able to find employment where their communication needs are accommodated. That, in turn, could hinder persistence.
A Technique to Fabricate La2O2CN2:Tb3+ Nanofibers and Nanoribbons with the Same Morphologies as the Precursors
Authors: Guo Xiaomin , Yu Wensheng , Dong Xiangting , Wang Jinxian , Ma Qianli , Liu Guixia , Yang Ming
Published: December 2014

Terbium(III)‐doped lanthanum dioxymonocyanamide (La2O2CN2:Tb3+) nanofibers and nanoribbons were fabricated, by the cyanamidation technique, from precursor La2O3:Tb3+ nanofibers and nanoribbons prepared by electrospinning. The morphology of the final products were the same as those of the precursors. X‐ray powder diffraction analysis indicated that the crystal phase of La2O2CN2:Tb3+ is tetragonal in space group I4/mmm. SEM analysis revealed that the thickness and width of the La2O2CN2:Tb3+ nanoribbons is about 184 nm and 3.53 ± 0.37 μm, respectively, and the diameter of the La2O2CN2:Tb3+ nanofibers is 175.87 ± 16.23 nm at a 95 % confidence level. When excited with a 274 nm ultraviolet light source, the La2O2CN2:Tb3+ nanostructures emit predominantly at 543 nm; this emission originates from the 5D4→7F5 energy level transition of the Tb3+ ion. It was found that the optimum molar concentration of Tb3+ ions for doping La2O2CN2:Tb3+ nanostructures is 3 %. The La2O2CN2:Tb3+ nanofibers exhibit a higher photoluminescence (PL) intensity than that exhibited by nanoribbons for the same doping concentration. Commission International de l'Eclairage (CIE) analysis demonstrated that color‐tuned luminescence can be obtained by changing the concentration of the doping activator ions and the nanostructure morphology. Possible formation mechanisms for the La2O2CN2:Tb3+ nanofibers and nanoribbons are also proposed. More importantly, the new technique employed in this paper and the preparation method are of universal significance for providing other rare earth oxycyanamide nanostructures with various morphologies.
Allylic oxidation of methyl 10‐undecenoate and nucleophilic additions to methyl 9‐oxo‐10‐undecenoate
Authors: Hinkamp Ludger , Schäfer Hans J.
Published: December 2014

Methyl 10‐undecenoate (2b) has been oxidized with tert‐butyl hydroperoxide/selenium dioxide and potassium dichromate to 53% of methyl 9‐oxo‐10‐undecenoate (4). Based on the conversion of 2b, the yield of 4 is 81%. Residual selenium in ester 5 was determined to be less than 1 ppm. The electrophilic double bond in enone 4 reacts in good to excellent yield with a variety of nucleophiles. With dimethyl malonate, acetylacetone, and methyl acetoacetate Michael–adducts at C‐11 of enone 4 were obtained in 88–99% yield. Corresponding additions were achieved with nitroethane, 1‐ and 2‐nitropropane in 78–89% yield. In a Nef–reaction some nitroalkyl adducts were converted to methyl esters of 9,12‐dioxofatty acids in 99% yield. In methanol/sodium methoxide the ester methyl 11‐methoxy‐9‐oxoundecanoate was obtained in 86% yield from enone 4. In a three step reaction with ammonium chloride/sodium cyanide, hydrochloric acid/acetic acid, and methanol/2,2‐dimethoxypropane the ester 4 yielded 63% of dimethyl 4‐oxo‐dodecanedioate. With the cyanide ion the electrophilic carbon atom in aldehydes can be converted into a nucleophile (Stetter–reaction). Catalysed by sodium cyanide in DMF aromatic and heteroaromatic aldehydes RCHO with R = phenyl, 2‐thienyl, 2‐furyl and 3‐pyridyl were added to enone 4 to afford methyl 12‐aryl‐ and methyl 12‐heteroaryl‐9,12‐dioxododecanoates in 54–73% yield.

Practical applications: The prepared oleochemicals are useful as precursors for pharmaceuticals and as monomers for polyesters and polyamides. They also may be applied to synthesize fatty acid conjugates by providing suitable connectors for biological active compounds and to attach groups with suitable physical properties for materials.

For enone 4 prepared from methyl 10‐undecenoate, thirteen Michael additions with 1,3‐dicarbonyl and nitro alkyl compounds, hydrocyanic acid and acyl anions are reported.
A Metal‐Catalyzed Tandem 1,4‐Benzodiazepine Synthesis Based on Two Hydrogen‐Transfer Reactions
Authors: Jumde Varsha R. , Cini Elena , Porcheddu Andrea , Taddei Maurizio
Published: December 2014

Starting from 2‐aminobenzyl alcohols and 1,2‐amino alcohols, 2,3,4,5‐tetrahydro‐1H‐1,4‐benzodiazepines (TH‐BDZ) can be prepared through a one‐pot ruthenium‐catalyzed reaction encompassing two consecutive borrowing hydrogen cycles. First, benzyl alcohol oxidation, condensation with the amino alcohol, and imine reduction occurs. This is followed by oxidation of the other alcohol functionality and reductive cyclocondensation to give the TH‐BDZ derivatives. A single catalyst does the entire job, with two molecules of water being the only waste product. Many new substituted 2,3,4,5‐tetrahydro‐1H‐1,4‐benzodiazepines have been prepared to demonstrate the versatility of this method, which can be used for the preparation of privileged scaffolds for drug discovery.
Multigram Synthesis of Fluoroalkyl‐Substituted Pyrazole‐4‐carboxylic Acids
Authors: Iminov Rustam T. , Mashkov Alexander V. , Vyzir Ivan I. , Chalyk Bohdan A. , Tverdokhlebov Anton V. , Mykhailiuk Pavel K. , Babichenko Ludmila N. , Tolmachev Andrey A. , Volovenko Yulian M. , Biitseva Angelina , Shishkin Oleg V. , Shishkina Svetlana V.
Published: December 2014

Acylation of tert‐butyl 3‐(methylamino)but‐2‐enoate with fluorinated acetic acid anhydrides occurred at the enamine carbon atom. The reaction of the resulting tert‐butyl 3‐(methylamino)‐2‐(RFCO)but‐2‐enoates with alkyl hydrazines resulted in mixtures of isomeric pyrazoles that were easily separated by column chromatography. The target fluorinated pyrazole‐4‐carboxylic acids were obtained on a multigram scale.
From Chrysene to Double [5]Helicenes
Authors: Bock Harald , Huet Stephanie , Dechambenoit Pierre , Hillard Elizabeth A. , Durola Fabien
Published: December 2014

Glyoxylic functionalization of chrysene by Friedel–Crafts acylation with ethyl chloroglyoxylate or by bromination followed by substituent exchange enables the formation of bis[5]helicene‐tetracarboxylates and tetracarboxdiimides through Perkin reactions and palladium‐catalyzed cyclizations. Tetrasubstituted bishelicenic dichrysenoanthracenes and dinaphthochrysenes are thus obtained from chrysene in four to six steps. In the cyclization to dinaphthochrysenes, a rearrangement of the conjugated carbon skeleton is identified as side reaction. In solution, the diimides form mixtures of M,P‐ and M,M/P,P‐diastereomers, which equilibrate at room temperature when the helices are distant but equilibrate only upon heating when the helices are close and acting in concert. The nonplanar arene geometry allows close π‐contacts in two dimensions between neighboring molecules in the crystal.