bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Zingiber montanum Herbal Compress Remedy for Pain Management: An Updated Systematic Review and Meta-Analysis
Authors: Worasing Kanjana , Sungthong Bunleu , Phimarn Wiraphol
Published: May 2023

The Zingiber montanum herbal compress remedy is a type of herbal medicine that can be used as an alternative treatment for improving pain symptoms. This study aimed to evaluate the clinical efficacy of a Z. montanum herbal compress remedy for pain relief. PubMed, Scopus, ScienceDirect, and Thai databases were systematically searched for relevant articles published from inception to December 2022. Only randomized clinical trials (RCTs) wherein the efficacy of the Z. montanum remedy was compared to that of a placebo or non-steroidal anti-inflammatory drugs (NSAIDs) were included. Six RCTs with a total of 812 patients were included in the analysis. The efficacy of the Z. montanum remedy had a significantly decreased pain score compared to the placebo (SMD = −0.63; 95% CI = −1.20, −0.06; I2 = 90%), but there was no significant difference when compared to NSAIDs (SMD = −0.61; 95% CI = −1.41, 0.81; I2 = 73%). Moreover, the efficacy of the Z. montanum remedy in terms of the flexibility score (SMD = 0.59; 95% CI −0.56, 1.74; I2 = 86.0%) and quality of life (SMD = 0.34; 95% CI −0.38, 1.05; I2 = 81.0%) was similar to that of the placebo. This meta-analysis demonstrates that the use of the Z. montanum herbal compress remedy significantly reduces the pain scores reported by patients.
Improvement of Gd(III) Solvent Extraction by 4-Benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one: Non-Aqueous Systems
Authors: Atanassova Maria , Kukeva Rositsa
Published: May 2023

The study of the liquid–liquid extraction of gadolinium (Gd(III) ion) with a chelating compound, 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one (HP), and the determination of the process parameters are presented by employing two ionic liquids, namely, ([C1Cnim+][Tf2N−], n = 4, 10) and CHCl3, as diluents. Compared to CHCl3, the ionic liquid offers increased distribution ratios in an aqueous medium. A step forward, enhanced solvent extraction, and improved separation upon the addition of ethylene glycol are demonstrated, i.e., a boost of two immiscible organic phases, compared to traditional aqueous solutions. However, this is noticeable when using CHCl3, but unfortunately not with ionic liquid combination, [C1C10im+][Tf2N−]. Several conclusions are given, highlighting the role of the ionic diluent in complexation processes and selectivity with an employment of the chelating agent HP for various metal s-, p-, d-, and f-cations, i.e., nearly 25 metals. A detailed evaluation of the selectivity between these metals was made when changing both the aqueous phase completely with ethylene glycol or partially with glycerol (1:1). Electron paramagnetic resonance (EPR) spectroscopy has been used to study the established chemical species in the obtained organic extracts, such as Gd3+, Fe3+, Cu2+, and Cr3+, with unpaired electrons.
Geographical Origin Authentication of Edible Chrysanthemum morifolium Ramat. (Hangbaiju) Using Stable Isotopes
Authors: Mei Hanyi , Nie Jing , Wang Shu , Zhang Yongzhi , Li Chunlin , Shao Shengzhi , Shao Shanshan , Rogers Karyne M. , Yuan Yuwei
Published: May 2023

Chrysanthemum morifolium Ramat., known as Hangbaiju (HBJ), is a high-value edible, medicinal product where the flowers are infused in hot water and drunk as tea. Its quality and efficacy are closely related to its geographical origin. Consequently, it is vulnerable to fraudulent substitution by other lower-value Chrysanthemum products. In this study, cultivation (variety and different growth stages) and isotopic fractionation between the flower, stem, and leaf were studied. Samples from four different HBJ varieties were characterized using stable isotopes (δ13C, δ15N, δ2H, δ18O, %C, and %N) across three producing regions in Zhejiang province, China. The results showed that there were no significant differences in stable isotopic compositions for different HBJ varieties, but there were significant differences for different plant tissues (flower, stem, leaf, etc.). Furthermore, the stable isotopic composition altered dramatically at different growth stages. The δ15N (r = 0.6809) and δ2H (r = 0.6102) correlations between stems and leaves (SL) and flowers (F) of HBJ were relatively good, the δ13C correlation (r = 0.2636) between SL and F was weak, but δ18O correlation (r = 0.01) had almost no correlation. A supervised multivariate statistical model (partial least squares discriminant analysis, PLS-DA) was used to discriminate three different producing regions with high accuracy (66.7%, 66.7%, and 100%, respectively). Our findings show that stable isotopes combined with multivariate statistical analysis provide an effective method for the geographical identification of HBJ.
Workplace-Related Socioeconomic Issues Associated with Job Performance and Productivity among Employees with Various Impairments: A Systematic Literature Review
Authors: Gulyamova Saodat Tolibovna , Abdul Aziz Siti Fardaniah , Omar Nik Hairi , Mohd Rusyda Helma
Published: May 2023

The main purpose of this article is to present a systematic literature review of socioeconomic issues such as employee productivity, workplace absenteeism, workplace presenteeism, productivity loss, and indirect costs among employees with different impairments/disabilities. The related articles were obtained from the Scopus and Web of Science (WOS) databases. In general, 568 studies were found. A total of 141 articles were identified as open-access and non-duplicate articles in English in which disability-related issues among employees were raised. Ultimately, only 22 studies were selected for analysis since they were concerning socioeconomic issues associated with productivity and job performance among employees with various impairments. Based on the studies, workplace performance among employees with and without disabilities was almost equal. Workplace absenteeism and short-term disability costs were higher among employees with acromegaly, migraine, gout, depression, cardiovascular events and related clinical procedures, chronic diseases, and metastatic breast cancer. Mood disorders, heart diseases, and bowel disorders were the principal causes of absenteeism among employees with chronic conditions. Productivity loss was higher among employees with depression, psoriatic arthritis, multiple sclerosis, chronic migraine disease, and employees who received injectable multiple myeloma therapy. Worsening physical health, more functional disabilities, poorer relations with a supervisor, recurrent sick leave, back problems, mood disorders, migraine, and fatigue were the primary reasons for lost productivity.
A Review of Propagation and Restoration Techniques for American Beech and Their Current and Future Application in Mitigation of Beech Bark Disease
Authors: Myers Andrea L. , Storer Andrew J. , Dickinson Yvette L. , Bal Tara L.
Published: May 2023

The American beech (Fagus grandifolia Ehrh.) has been impacted by the beech bark disease (BBD) complex throughout the northeastern United States for over 100 years, but the disease has been present in the Great Lakes region only for around 20 years, requiring acknowledgement of the evolving context surrounding F. grandifolia. This disease threatens to remove a foundational tree species which is especially important ecologically for wildlife habitat and mast, and as a climax successional species. We review advances in propagation techniques of F. grandifolia with the goal of addressing their use in the rehabilitative restoration of forests affected by BBD. Natural regeneration and artificial methods of propagation are addressed, along with how they may be applied for mitigation. Silvicultural interventions are discussed that may be necessary to protect and release resistant seedlings to promote persistence. An existing framework is used to explore context necessary for decision making in restoration. Nucleated seed orchards of resistant trees may currently be the most effective and practical method for introduction of BBD-resistant F. grandifolia into affected northern hardwood forests.
Reuse of Treated Wastewater: Drivers, Regulations, Technologies, Case Studies, and Greater Chicago Area Experiences
Authors: Reddy Krishna R. , Kandou Valeria , Havrelock Rachel , El-Khattabi Ahmed Rachid , Cordova Teresa , Wilson Matthew D. , Nelson Braeden , Trujillo Citlalli
Published: May 2023

Water reuse is a practical solution to augment water supplies in areas where water resources are increasingly scarce. Water reuse technology is versatile and can be used to alleviate the different causes of water scarcity, such as groundwater depletion or increased availability of brackish water. Treatment technologies can be tailored specifically to the end use of recycled water, focusing on these drivers that are region-specific, for a more cost-effective treatment system. This is called a “Fit-for-Purpose” strategy that is commonly implemented in any water reuse project. However, implementing water reuse can be challenging due to infrastructural requirements, economic issues, and social acceptance. To help navigate these challenges, this article provides a comprehensive review of water reuse cases and presents guidelines that can act as a reference framework for future water reuse projects. This article also makes the case for implementing water reuse in the Greater Chicago area as a means of alleviating pressure on withdrawals from Lake Michigan.
Digital Transformation Strategies, Practices, and Trends: A Large-Scale Retrospective Study Based on Machine Learning
Authors: Gurcan Fatih , Boztas Gizem Dilan , Dalveren Gonca Gokce Menekse , Derawi Mohammad
Published: May 2023

The purpose of this research is to identify the areas of interest, research topics, and application areas that reflect the research nature of digital transformation (DT), as well as the strategies, practices, and trends of DT. To accomplish this, the Latent Dirichlet allocation algorithm, a probabilistic topic modeling technique, was applied to 5350 peer-reviewed journal articles on DT published in the last ten years, from 2013 to 2022. The analysis resulted in the discovery of 34 topics. These topics were classified, and a systematic taxonomy for DT was presented, including four sub-categories: implementation, technology, process, and human. As a result of time-based trend analysis, “Sustainable Energy”, “DT in Health”, “E-Government”, “DT in Education”, and “Supply Chain” emerged as top topics with an increasing trend. Our findings indicate that research interests are focused on specific applications of digital transformation in industrial and public settings. Based on our findings, we anticipate that the next phase of DT research and practice will concentrate on specific DT applications in government, health, education, and economics. “Sustainable Energy” and “Supply Chain” have been identified as the most prominent topics in current DT processes and applications. This study can help researchers and practitioners in the field by providing insights and implications about the evolution and applications of DT. Our findings are intended to serve as a guide for DT in understanding current research gaps and potential future research topics.
The Effect of Perceived Corporate Social Responsibility (PCSR) on Subjective Well-Being
Authors: Liang Teng Yue , Yoon Sung Joon
Published: May 2023

With the improvement of the material level, the employees of companies do not only pay attention to the level of wages, but rather focus on the happiness that the work induces, the quality of life, and the psychological well-being. Current research on corporate social responsibility has mostly concerned both macroscopic and institutional aspects, and empirical studies that address microscopic aspects of the organization employees are relatively scant. Therefore, it is the aim of this study to investigate whether corporate social responsibility perceived by employees affects subjective well-being, as well as to examine the intermediary mechanism through which employees perceive subjective well-being. Based on the social identity theory, this study establishes a research model that sets corporate social responsibility, organizational identification, and moral identity perceived by employees as antecedent variables of subjective well-being, and uses organizational support as a moderating variable. The survey data used in this study were collected from social media in the form of a questionnaire. The survey used a total of 508 questionnaires for employees of “Haier”, a Chinese home appliance manufacturing company, for one month in September 2022. The conclusions drawn through this study are that, first, corporate social responsibility has a significant positive (+) effect on subjective well-being, and, second, organizational identification mediates the relationship between perceived corporate social responsibility and subjective well-being. Third, moral identity plays a partial mediating role between perceived corporate social responsibility and subjective well-being. Finally, organizational support moderates the relationship between employees’ perceived corporate social responsibility and organizational identification. It is expected that the research result will contribute to better understanding of the mechanism in which perceived corporate social responsibility boosts employees’ subjective well-being, which has huge implications for companies in ways that affect organizational performance as well as corporate loyalty.
Is Sustainability Reporting Promoting a Circular Economy? Analysis of Companies’ Sustainability Reports in the Agri-Food Sector in the Scope of Corporate Sustainability Reporting Directive and EU Taxonomy Regulation
Authors: Falkenberg Christof , Schneeberger Carina , Pöchtrager Siegfried
Published: May 2023

Circular economy has the potential to contribute significantly to sustainable development. Despite its popularity, implementation in Europe is still low. Through more stringent sustainability reporting, the circular economy should be increasingly implemented by companies, which is currently pursued by the EU through two new legal acts. Therefore, we need a more integrated understanding of existing practices of corporate sustainability reporting to identify weak points and possibilities for further improvement. This article aims to (i) investigate whether companies in the agri-food sector have reported on the circular economy so far, (ii) to what extent future legal obligations are already being met, and (iii) if the two new EU legal acts hold significance for the promotion of circular economy through corporate reporting. To assess the current reporting practices, a qualitative content analysis and a mapping approach of 20 selected sustainability reports from key players in the agri-food sector have been conducted. Additionally, seven semi-structured expert interviews were carried out to review the future role of the legal acts. Results show that reporting in the agri-food sector on circular economy has increased considerably as of 2016, but it is still lacking in terms of the two new legal acts. Although the Global Reporting Initiative (GRI) can be seen as a good basis for reporting, there is a large number of new obligations, which means that companies should start preparing at an early stage. This is especially true for those agri-food companies that have not yet been subjected to any reporting obligations. Experts have agreed with this view, considering the legal acts as an important vehicle for promoting the concept. However, they also recognize the weaknesses, such as the existing scope for interpretation, which still need to be addressed before the final publication of the standard and the technical criteria. Future research should analyze the final commitments of the reports (including for small and medium-sized companies), compare them with established reporting standards, seek expert opinions on them, and quantitatively examine sustainability reports in this and other industries.
A Performance Quality Index to Assess Professional Conduct of Contractors at Sustainable Construction Projects in Saudi Arabia
Authors: Shaawat Mohamed Essam , Alqahtani Saleh Mohammed Saed , Qasem Altayeb , Jamil Rehan , Almohassen Abdulaziz S. , Bongwirnso Umaru Mohammed
Published: May 2023

The quality performance of contractors in sustainable construction projects is a major concern for the industry. Over the past decade, studies on measurements, factors, and indicators for assessment of the professional conduct of construction companies are to be found in the sustainable construction management literature. There is adequate evidence over the last decade that an increasing number of construction professionals have adopted the measurement of the professional conduct of contractors as a tool to support their future decisions. The method of the Analytical Hierarchy (AHP) process has been deployed to identify the major factors and sub-factors involved in sustainable construction in Saudi Arabia. Using several governing factors, including quality of document submittals (QDS), quality system implementation (QSI), and quality of construction works (QCW), a working framework was developed by using the pair-wise comparison method. The results show that proper accountability and keen consideration of factors that could hinder sustainable construction by contractors contribute to the development of a better perspective on quality issues. After a critical analysis, a Performance Quality Index was developed, and a benchmark value was obtained. The benchmark value of PQI will assist project managers and owners in the sustainable construction sector as a reference for future improvement in the quality performance of contractors.
Student Attitudes and Interests in STEM in Qatar through the Lens of the Social Cognitive Theory
Authors: Sellami Abdel Latif , Al-Ali Abdulla , Allouh Amani , Alhazbi Saleh
Published: May 2023

STEM (science, technology, engineering, and math) has taken center stage as a priority policy agenda for Qatar’s leadership. At present, STEM stands as a fundamental catalyst for Qatar’s sustainable economic, environmental, human, and social development goals, as is outlined in the Qatar National Vision 2030. The aim of this exploratory study was to investigate the determinants of students’ interest in pursuing Science, Technology, Engineering, and Mathematics (STEM) studies and eventual careers in Qatar. This study used a survey involving a representative sample of a total of 425 students from public (government-funded) middle schools in the country. Data for this research were gathered using a survey distributed to students in grades 7, 8, and 9. Guided by the Social Cognitive Theory, a survey was implemented with a view to investigating the intrinsic and extrinsic factors likely to contribute to student STEM educational and career interest. Two main statistical tests were carried out: independent sample t-tests and one way ANOVA. Results derived from the study reveal that gender, nationality, and parental education and occupation served as predictors of student interest in a STEM degree or profession. The results derived from this study have important implications for STEM-related fields of study and career.
Primary Human Ligament Fibroblast Adhesion and Growth on 3D-Printed Scaffolds for Tissue Engineering Applications
Authors: Lacombe Jean-Gabriel , Cooke Megan , Park Hyeree , Alshammari Suliman , Gawri Rahul , Nazhat Showan , Martineau Paul , Rosenzweig Derek
Published: May 2023

The current gold standard technique for the treatment of anterior cruciate ligament (ACL) injury is reconstruction with a tendon autograft. These treatments have a relatively high failure and re-rupture rate and are associated with early-onset osteoarthritis, developing within two decades of injury. Furthermore, both autografting and allografting come with several drawbacks. Tissue engineering and additive manufacturing present exciting new opportunities to explore 3D scaffolds as graft substitutes. We previously showed that 3D-printed scaffolds using low-cost equipment are suitable for tissue engineering approaches to regenerative medicine. Here, we hypothesize that Lay-Fomm 60, a commercially available nanoporous elastomer, may be a viable tissue engineering candidate for an ACL graft substitute. We first printed nanoporous thermoplastic elastomer scaffolds using low-cost desktop 3D printers and determined the mechanical and morphological properties. We then tested the impact of different surface coatings on primary human ACL fibroblast adhesion, growth, and ligamentous matrix deposition in vitro. Our data suggest that poly-L-lysine-coated Lay-Fomm 60 scaffolds increased ligament fibroblast activity and matrix formation when compared to uncoated scaffolds but did not have a significant effect on cell attachment and proliferation. Therefore, uncoated 3D printed Lay-Fomm 60 scaffolds may be viable standalone scaffolds and warrant further research as ligament tissue engineering and reconstruction grafts.
Spatial Distribution and Risk Assessment of Heavy Metal(oid)s Contamination in Topsoil around a Lead and Zinc Smelter in Henan Province, Central China
Authors: Yang Ling , Ge Shiji , Liu Jinhui , Iqbal Younas , Jiang Yuling , Sun Ruiling , Ruan Xinling , Wang Yangyang
Published: May 2023

A total of 137 farmland soil samples were collected around a lead/zinc smelter within 64 km2. The concentration, spatial distribution, and potential source of nine heavy metal(oid)s (As, Cd, Co, Cr, Cu, Ni, Pb, V, and Zn) in soils and their potential ecological risk were investigated in detail. The results showed that the average concentrations of Cd, Pb, Cr and Zn in these soils were higher than their background value in Henan Province, and the average content of Cd was 2.83 times of the risk screening values in the national standard of China (GB 15618-2018). According to the distribution of different heavy metal(oid)s in soils, Cd and Pb in soil decrease gradually with the increase of distance from the smelter to the surrounding area. This indicates that the Pb and Cd originate from smelters via airborne practices according to the typical air pollution diffusion model. The distribution of Zn, Cu, and As were similar to Cd and Pb. However, Ni, V, Cr, and Co were mainly affected by soil parent materials. The potential ecological risk of Cd was higher than those of other elements, and the risk grade of the other eight elements was mainly low. The polluted soils with significantly high and high potential ecological risk covered 93.84% of all the studied regions. This should be of serious concern to government. The results of a principal component analysis (PCA) and cluster analysis (CA) show that Pb, Cd, Zn, Cu, and As were the elements mainly stemmed from smelter and other types of plants, with a contribution rate of 60.08%, while Co, Cr, Ni, and V are mainly caused by nature, with a contribution rate of 26.26%.
Evaluating the Impact of Individual and Combined Toxicity of Imidacloprid, Cycloxaprid, and Tebuconazole on Daphnia magna
Authors: Man Yanli , Sun Tian , Wu Chi , Liu Xingang , He Mingyuan
Published: May 2023

The risks posed by chemicals in the environment are typically assessed on a substance-by-substance basis, often neglecting the effects of mixtures. This may lead to an underestimation of the actual risk. In our study, we investigated the effects of three commonly used pesticides—imidacloprid (IMI), cycloxaprid (CYC), and tebuconazole (TBZ)—both individually and in combination, using various biomarkers to assess their impact on daphnia. Our findings indicated that the order of toxicity, from highest to lowest, was TBZ, IMI, and CYC, as determined by acute toxicity as well as reproduction. The effects of the ITmix (IMI and TBZ) and CTmix (CYC and TBZ) combinations on immobilization and reproduction were evaluated by MIXTOX, revealing a higher risk of immobilization at low concentrations for ITmix. The effect on reproduction differed depending on the ration of pesticides in the mixture, with synergism observed, which may be caused mainly by IMI. However, CTmix showed antagonism for acute toxicity, with the effect on reproduction depending upon the composition of the mixture. The response surface also exhibited a switch between antagonism and synergism. Additionally, the pesticides extended the body length and inhibited the development period. The activities of superoxide dismutase (SOD) and catalase (CAT) content was also significantly induced at different dosage points in both the single and combination groups, indicating changes in the metabolic capabilities of detoxifying enzymes and target site sensitivity. These findings highlight the need for more attention to be focused on the effects of pesticide mixtures.
Gene Expression Profiling of Classically Activated Macrophages in Leishmania infantum Infection: Response to Metabolic Pre-Stimulus with Itaconic Acid
Authors: Palacios Génesis , Vega-García Elva , Valladares Basilio , Pérez José Antonio , Dorta-Guerra Roberto , Carmelo Emma
Published: May 2023

Leishmania infection of phagocytic cells, such as macrophages, induces the differentiation of infected cells into different phenotypes according to their surrounding microenvironments. The classical activation of macrophages involves metabolic reprogramming, in which several metabolites such as succinate, fumarate and itaconate are accumulated. The immunoregulatory functions of itaconate in the context of Leishmania infection were investigated in this paper. Ex vivo bone marrow-derived macrophages were differentiated into classically activated macrophages through IFNG activation and infection with Leishmania infantum. A high-throughput real-time qPCR experiment was designed for the analyses of 223 genes involved in immune response and metabolism. The transcriptional profile of classically activated macrophages revealed the enrichment of the IFNG response pathways and the upregulation of genes such as Cxcl9, Irf1, Acod1, Il12b, Il12rb1, Nos2 or Stat1. In vitro pre-stimulation with itaconate induced a loss of the parasite control and the upregulation of genes related to local acute inflammatory response. Our results reveal that itaconate accumulation dampened classically activated macrophage antiparasitic activity, and this is reflected by the differential expression of the Il12b, Icosl and Mki67 genes. The possibility of inducing parasite-killing responses in the host through metabolic reprograming is an interesting approach for the treatment of Leishmania infections that will undoubtedly attract increasing attention in the coming years.
Hepatitis B Core Antibody Level: A Surrogate Marker for Host Antiviral Immunity in Chronic Hepatitis B Virus Infections
Authors: Shi Yang , Wang Zihan , Ge Shengxiang , Xia Ningshao , Yuan Quan
Published: May 2023

The hepatitis B virus core protein (HBcAg) is a highly immunogenic particulate antigen. Nearly all patients with persistent or resolved hepatitis B virus (HBV) infection show seropositivity for hepatitis B core antibody (anti-HBc), which appears in the early stage of infection and is mostly present for life. Traditionally, the anti-HBc is regarded as an evidential serological marker of HBV infections. In the last ten years, several studies revealed the predictive value of quantitative anti-HBc (qAnti-HBc) level in the treatment response and clinical outcome of chronic HBV infections, implying new insights into this classic marker. Overall, qAnti-HBc should be regarded as an indicator of the host’s immune response specific to HBV, which correlates with HBV-related hepatitis activity and liver pathology. This review summarized the latest understanding of the clinical values of qAnti-HBc for differentiating the CHB phase, predicting treatment response, and providing disease prognosis. Moreover, we also discussed the possible mechanism of qAnti-HBc regulation during different courses of HBV infection.
You Shall Not Pass: MX2 Proteins Are Versatile Viral Inhibitors
Authors: Betancor Gilberto
Published: May 2023

Myxovirus resistance (MX) proteins are pivotal players in the innate immune response to viral infections. Less than 10 years ago, three independent groups simultaneously showed that human MX2 is an interferon (IFN)-stimulated gene (ISG) with potent anti-human immunodeficiency virus 1 (HIV-1) activity. Thenceforth, multiple research works have been published highlighting the ability of MX2 to inhibit RNA and DNA viruses. These growing bodies of evidence have identified some of the key determinants regulating its antiviral activity. Therefore, the importance of the protein amino-terminal domain, the oligomerization state, or the ability to interact with viral components is now well recognized. Nonetheless, there are still several unknown aspects of MX2 antiviral activity asking for further research, such as the role of cellular localization or the effect of post-translational modifications. This work aims to provide a comprehensive review of our current knowledge on the molecular determinants governing the antiviral activity of this versatile ISG, using human MX2 and HIV-1 inhibition as a reference, but drawing parallelisms and noting divergent mechanisms with other proteins and viruses when necessary.
Enterovirus 71-Associated Infection in South Vietnam: Vaccination Is a Real Solution
Authors: Romanenkova Natalia I. , Nguyen Thi Thanh Thao , Golitsyna Liudmila N. , Ponomareva Natalia V. , Rozaeva Nadezhda R. , Kanaeva Olga I. , Leonov Artem V. , Novikova Nadezhda A. , Bichurina Maina A.
Published: May 2023

Hand-foot-and-mouth disease (HFMD) is the most common enteroviral infection in South-East Asia. When evaluating the role of enterovirus 71 (EVA71) as an etiological agent of infectious disease in South Vietnam, we revealed a high proportion of EVA71 among identified species A enteroviruses found in 3542 samples from HFMD cases; 125 samples from cases of enteroviral meningitis; and 130 samples from acute flaccid paralysis (AFP) cases. These represent 50%, 54.8%, and 51.5%, respectively. According to molecular analysis, 90% of EVA71 were attributed to genotype C4 and 10% were attributed to genotype B5. The predominance of EVA71 circulation among the population proves the need to strengthen surveillance (with monitoring of enterovirus circulation for facilitation of HFMD outbreak prediction) and to increase the effectiveness of preventative measures by the implementation of vaccination against EVA71-associated infections. A phase III trial of a Taiwanese vaccine (EV71vac) in Taiwan and South Vietnam showed its safety, tolerability, and efficacy in children aged 2–71 months. This B4 genotype-based vaccine, which features cross-protection against B5 and C4 genotypes, and other existing EV71 vaccines can serve as a good approach to solving the HFMD problem, which is so important for Vietnam.
Impact of Health Workers’ Choice of COVID-19 Vaccine Booster on Immunization Levels in Istanbul, Turkey
Authors: Ören Meryem , Canbaz Sevgi , Meşe Sevim , Ağaçfidan Ali , Demir Ömer , Karaca Esra , Doğruyol Ayşe , Otçu Gökçe , Tükek Tufan , Özgülnar Nuray
Published: May 2023

Background: There are limited data regarding short- and medium-term IgG antibody levels after the CoronaVac and BNT162b2 vaccines. This study aimed to investigate the antibody responses of health workers who initially received two doses of CoronaVac one month apart followed by a booster dose of either CoronaVac or BNT162b2, as well as determine whether either vaccine provided superior results. Methods: This research represents the second phase of a mixed-methods vaccine cohort study and was conducted between July 2021 and February 2022. The participants (n = 117) were interviewed in person and blood samples were collected before and at 1 and 6 months after the booster vaccination. Results: BNT162b2 was found to have greater immunogenic potential than CoronaVac (p < 0.001). Health workers without chronic disease exhibited statistically significant increases in antibody levels after both vaccines (p < 0.001), whereas only BNT162b2 caused a significant increase in antibody levels in participants with chronic disease (p < 0.001). Samples obtained before and at 1 and 6 months after the booster vaccination revealed no age- or sex-based differences in IgG-inducing potential for either vaccine (p > 0.05). Antibody levels were comparable in both vaccine groups before the booster regardless of COVID-19 history (p > 0.05); however, antibody levels were significantly higher after the BNT162b2 booster at 1 month (<0.001) and at 6 months, except among participants who had a positive history of COVID-19 infection (p < 0.001). Conclusions: Our results suggest that even a single booster dose of BNT162b2 after initial vaccination with CoronaVac provides a protective advantage against COVID-19, especially for risk groups such as health workers and those with chronic diseases.
Effect of Simulated Transport Conditions on Microbiological Properties of Bottled Natural Mineral Water
Authors: Tihanyi-Kovács Renáta , Ásványi Balázs , Lakatos Erika , Bánáti Ferenc , Varga László , Böröcz Péter
Published: May 2023

Bottled mineral water is distributed globally through complex supply chains, making it available far beyond its bottling plants. In low-viscosity food matrices, invisible changes may occur due to shaking. The primary purpose of this research was to investigate the potential correlation between the intensity of mechanical agitation and the number of detectable microorganisms in bottled mineral water. The simulation of dynamic mechanical vibration was conducted using both time-accelerated and real-time tests. Freshly bottled natural mineral water and commercially available mineral water brands from different bottling locations and times were subjected to random vibration at three intensities as specified by the ASTM D-4169-16 standard, which simulates road transport on semi-trailer trucks. The study investigated the specific growth rate, the generation time, and the maximum cell numbers of microorganisms. The quantitative PCR (qPCR) technique was used to determine and compare the concentrations of microbes. Dynamic mechanical vibration affected the microbiome of mineral waters, influencing growth rates and generation times. In the case of waters from different bottling locations and times, the specific growth rate varied significantly for each water and for each intensity. This finding demonstrates that the microbiome composition of the water source and the interaction between microbes influence the response to mechanical impact. The time-accelerated test was shown to be suitable for analyzing the reaction of the microbiome of the tested matrix to the intensity and duration of vibration. The applied test protocol enabled the monitoring of changes in cell numbers by qPCR. All three intensities of the time-accelerated method were effective in testing the effects of real-time mechanical agitation on the microbiome.
Bacterial Contamination Levels and Brand Perception of Sachet Water: A Case Study in Some Nigerian Urban Neighborhoods
Authors: Tenebe Imokhai T. , Babatunde Eunice O. , Eddy-Ugorji Chinonso C. , Etu Egbe-Etu E. , Ogarekpe Nkpa M. , Ekeanyanwu Chikodinaka V. , Diekola Oladapo A. , Oladele Oluwarotimi S. , Ezeudu Obiora B.
Published: May 2023

Sachet water (SW) is a major source of drinking in most Nigerian homes, thus making it a possible conveyance medium for health risks due to contamination if persist rather than for replenishment of the body. This study collected SW from three busy neighborhoods in South-West Nigeria and investigated for the presence of indicator bacteria (Escherichia coli (E. coli), Total Coliform (TC), Total Heterophilic Bacteria (THB), Staphylococcus (Staph)) and some physio-chemical parameters (total dissolved solids (TDS), pH, electrical conductivity (EC), and salinity). Multi-variable and exploratory statistical methods were applied to the results to determine correlations between bacterial contamination levels and perceived brand reputation. Bacteriological tests with raw SW samples appeared too numerous to count (TNC) and thus required serial dilutions. After seven-fold serial dilutions, results obtained revealed that SW brands with good reputations had no TC and E. coli and was statistically significant with groupings of other SW brands (χ2 = 12.28; p < 0.05 and χ2 = 37.96; p < 0.05). Additionally, SW brands with poor reputations had mean values of TC (19.7×108 cfu/mL; 14×108 cfu/mL 1.15×108 cfu/mL) and E. coli (18.2×108 cfu/mL; 38.7×108 cfu/mL,32.4×108 cfu/mL) exceeding the threshold value of zero set by the World Health Organization (WHO). Only one sample from a poor reputation brand tested positive for Staphylococcus and was not statistically significant (χ2 = 5.2191; p = 0.074). Principal Component Analysis (PCA)/Factor Analysis (FA) revealed that most of the SW had fecal contamination was the major source. Therefore, this study suggests that periodic cleaning of distribution lines, location-specific treatment, and other quality control (QC) measures should be enforced to reduce water security risk for SW consumption in the region.
Effect of maxillary constriction orthodontic correction using a fixed appliance with a screw in teenagers during a growth spurt
Authors: Kosyreva T. F. , Biryukov A. S. , Voeykova O. V. , Samoylova M. V. , Gorshunova N. V. , Rasha Almasri , Gharawi Alhamzah
Published: May 2023

Relevance. The research is relevant because of a high prevalence of anterior and posterior crowding in children with mixed and permanent dentition (from 42 to 86 %), for whom the correction of the dentition form and the size is recommended by fixed expanding appliances with a screw. After the teenage growth spurt, the growth and development of jaws end, steady pathological signs form, there are psychological problems in a face and smile selfperception, and the question of the orthodontic treatment duration arises.

Purpose. To study the effectiveness of treatment of patients with maxillary premolar area constriction during growth spurt using two modifications of fixed Hyrax expander.

Material and methods. We examined 22 male patients aged 10.6 to 13 y.o. (average age 11.2 ± 1.6 years old) with permanent dentition, constriction of the posterior teeth and crowding of incisors, treated with a fixed expander (Hyrax appliance) in the upper jaw during the growth spurt. The patients formed two groups. Group 1 (n = 11) had the Hyrax screw at the level of the upper first premolars, and Group 2 (n = 11) had the Hyrax lock located at the first permanent molars. The patients activated the expander independently by ¼ turn every other day for six months. Then the appliance remained in the mouth for three months. We studied the maxillary expansion results on plaster models before and after six months of the expander fixation using the Tonn, Pont, Korkhaus, Bolton method.

Results. The study has established that orthodontic correction of transversal abnormalities with a fixed Hyrax expander affects the maxillary posterior teeth expansion, changes their parameters and improves their movement. At the same time, in Group 1, the width between the first premolars and the first molars reached the norm calculated from the sum of the mesiodistal dimensions of the upper incisors, and in Group 2, the width between the first permanent molars exceeded the normal, and inter-first-premolar distance did not reach the normal values for three months of activation.

Conclusion. Fixed Hyrax expander showed the best results if the screw was at the level of first premolars during the teenage growth spurt.
Relationship between the inexact Newton method and the continuous analogy of Newton's method
Authors: Zhanlav T. , Chuluunbaatar O. , Ankhbayar G.
Published: May 2023

In this paper we propose two new strategies to determine the forcing terms that allow one to improve the efficiency and robustness of the inexact Newton method. The choices are based on the relationship between the inexact Newton method and the continuous analogy of Newton's method. With the new forcing terms, the inexact Newton method is locally \(Q\)-superlinearly and quadratically convergent. Numerical results are presented to support the effectiveness of the new forcing terms.
Schur convexity properties of the weighted arithmetic integral mean and Chebyshev functional
Authors: Bo-Yong Long , Yue-Ping Jiang , Yu-Ming Chu
Published: May 2023

In this paper, we discuss the Schur convexity, Schur geometrical convexity and Schur harmonic convexity of the weighted arithmetic integral mean and Chebyshev functional. Several sufficient conditions, and necessary and sufficient conditions are established.
On an iterative algorithm of Ulm-type for solving equations
Authors: Argyros Ioannis K. , Khattri Sanjay K.
Published: May 2023

We provide a semilocal convergence analysis of an iterative algorithm for solving nonlinear operator equations in a Banach space setting. This algorithm is of order \(1.839\ldots\), and has already been studied in [3, 8, 18, 20]. Using our new idea of recurrent functions we show that a finer analysis is possible with sufficient convergence conditions that can be weaker than before, and under the same computational cost. Numerical examples are also provided in this study.
Certain properties for a class of analytic functions associated with hypergeometric functions
Authors: Alhindi Khadeejah R. , Darus Maslina
Published: May 2023

In this particular paper, we investigate coefficient inequalities, closure theorems, convolution properties for the functions belonging to the class \( \mathcal{S}^{m,r,s}_{\lambda_1,\lambda_2}(\eta)\). Further, integral transforms of functions in the same class are also discussed.
Educational Needs of North Carolina Non-industrial Private Forest Landowners and Barriers to Meeting These Needs
Authors: Bardon Robert , Peters Kristin , Parajuli Rajan , Jayaratne Koralalage
Published: May 2023

Forest landowners are an important target audience for many state Extension programs. Acknowledging the differences and associations between landownership values, characteristics, and educational preferences of forest landowners should lead to improvement of educational programs and ensuring that educational needs are being met. Through an internet-based survey of forest landowners four distinct landowner typologies were identified based on respondents’ reason for owning forestland. Results also identified the educational needs and barriers to meeting these needs for the landowners. Creating typologies based on attitudinal responses will allow for a more focused approach to developing educational products and services to meet landowner needs.
A Small-scale Wave Tank For Living Shoreline Extension And Outreach
Authors: Chenier Keith , Akers Jaden , Liner Skylar , Harrier Shelby , Sparks Eric , Biber Patrick , Blackmon Laura , Kastler Jessica , Broussard Patrick
Published: May 2023

Hardened structures, such as bulkheads and seawalls, are currently the primary choice of shoreline protection for waterfront property owners. However, hardened shorelines are known to enhance erosion and often promote the loss of intertidal habitat. Living shorelines are a collection of environmentally friendly construction techniques that serve as an alternative to hardened shorelines through the incorporation of natural materials, such as native plants. To enhance extension and outreach efforts related to the promotion of living shorelines, we created a small-scale, hands-on wave tank that demonstrates the benefits of natural and living shorelines relative to hardened structures. This interactive tool allows the audience to view the differences between natural, living, and hardened shorelines for both aesthetics and wave energy reduction.
Maximizing the First-Year Planning Period for Scholarly Publications: Implications for Prospective CYFAR Grant Recipients
Authors: Eng Sothy , Sustarsic Manca , Ooki Nancy , Greenwood Heather , Hanakawa Christine
Published: May 2023

One of CYFAR's unique features is the built-in planning year for all grant recipients. We present our evaluation team’s approach during year 1 to establish a foundation and plan for scholarly publications during funding years 2–5. The systematic literature review provided the team with a better understanding of the culture and context of the project’s target population. Collaboration between PI/Co-PI and Evaluator served as a powerful tool to achieving this goal. Not only does this model benefit future CYFAR grant recipients’ and Extension professionals’ curriculum development and program evaluation, it can also inform recruitment efforts and community partnership development.
Qualitative Analysis of the Expanded Food and Nutrition Education Program’s 24-hour Dietary Recall
Authors: Fuller Serena , Phelps Josh , Baker Susan , Walsh Jennifer
Published: May 2023

The Expanded Food and Nutrition Education Program (EFNEP) uses a group 24-hour dietary recall (Gr24HDR) to measure changes in diet quality. Participant perceptions of the tool can guide implementation practices used by EFNEP Extension staff. Focus group (FG) sessions were conducted in five states and transcripts analyzed following a framework analysis approach. According to FG participants, a range of factors, condensed into six themes with potential interactions, influence Gr24HDR including implementation processes and community settings. Findings inform overarching considerations EFNEP staff may take when collecting Gr24HDR data in the field to improve the evaluation process for participants.
The Effects of Active Shootings on 4-H Youth and Families
Authors: Garcia Melinda , Gangwer Elizabeth
Published: May 2023

The effects of active shootings should be a priority to provide needed assistance to 4-H youth and families in coping with their social-emotional well-being. Exposure to such violence can lead to lasting impacts on youth that can affect behavior. Addressing this sensitive topic is crucial in ensuring that Extension professionals are prepared to meet the needs of youth and families. Higher rates of depression, aggression, to name a few, are a result of having witnessed such events as a shooting. Providing training for Extension personnel can aid in reducing the amount of PTSD and other social-emotional trauma.
Live Well, Eat Well, Be Active With Diabetes Curriculum Improves Type 2 Diabetes Management
Authors: Amaya Lauren , Baldwin Dana , Enyart Kathy , James Arleen , James Tommie , King Penny , Maples Jan , Peterman Lindy , Randolph Sara , Rash Dea , Ratcliff Kelsey , Rhodes Joy , Riggin Jessica , Risley Janis , Russell Danette , Hermann Janice
Published: May 2023

Type 2 diabetes is a complex disease with several modifiable lifestyle factors. The Extension ‘Live well, Eat well, be Active with Diabetes’ curriculum provides four 90-minute lessons teaching individuals to live well, eat well, and be active with diabetes. Fourteen Extension educators implemented and evaluated the curriculum with 107 participants. Participants reported the program helped them feel better able to take care of their health. We observed significant differences in participants’ retrospective pre and post ‘Live well,’ ‘Eat well’ and ‘be Active’ total scores. Extension has a unique opportunity to educate individuals so they may better manage their diabetes.
Selecting Appropriate Technology for an Effective Online Extension Course
Authors: Hill Paul , Ali Amanda , Swadley Emy , Goodrich Russell
Published: May 2023

Technology is a strategic asset in accomplishing the land grant mission. Selecting appropriate technology for Extension program management and delivery is essential to achieving planned outcomes, but can be challenging. This article describes the technology platforms selected by a new, legislatively funded Extension program delivering an online course in a hybrid distance-learning experience. The descriptions and application of these technology platforms will assist Extension professionals in choosing technology suitable for delivery and management of their programs as they plan for impact.