bluuebunny/crossref_metadata_2025 huggingface dataset:
Balancing detectivity and sensitivity of plasmonic sensors with surface lattice resonance
Authors: Li Zhichao , Prasad Ciril S. , Wang Xielin , Zhang Ding , Lach Rosemary , Naik Gururaj V.
Published: September 2023

Resonators are at the core of optical sensors enhancing light–analyte interaction and leading to higher sensitivities. Maximizing the sensitivity is an obvious objective function for the resonator design. However, high sensitivity does not guarantee sufficient detectivity. When the optical energy budget is limited, as in sensors on mobile platforms, a higher sensitivity usually leads to lower detectivity for nanophotonic sensors. In such scenarios, resonator design requires balancing the trade-off between the sensitivity and detectivity of the resonant sensor. Here, we show the direct dependence of detectivity on the Q-factor and the trade-off between the Q-factor and sensitivity. We study this trade-off in an array of plasmonic resonators. We choose plasmonic resonators because of their high sensitivity arising from large local field enhancements. Then, we show that the detectivity of this sensor may be boosted for limited energy budget applications by making an array of resonators supporting a surface lattice resonance (SLR). We experimentally demonstrate sensing and detection of antimouse IgG protein in a gold nanodisk array–based SLR sensor for various energy budgets.
Hydrothermal synthesis and crystal structure of catena-poly[diaqua-bis(μ2-4-((pyridin-4-ylmethyl)amino)benzoato-κ2
N:O)cobalt(II)] – 4,4′-bipyridine – water (1/2/2)
Authors: Liu Guang-Zhen , Wang Xin
Published: September 2023

C23H23Co0.5N4O4, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 9.6428(5) Å, b = 10.3191(5) Å, c = 11.8710(6) Å, α = 

86.664

(
4
)

∘

$86.664{(4)}^{\circ }$

, β = 

69.399

(
5
)

∘

$69.399{(5)}^{\circ }$

, γ = 

79.429

(
4
)

∘

$79.429{(4)}^{\circ }$

, V = 1086.90(10) Å3, Z = 2,

R

g
t

${R}_{\mathit{g}\mathit{t}}$

(F) = 0.0432,

w

R

r
e
f

$w{R}_{\mathit{r}\mathit{e}\mathit{f}}$

(F
2) = 0.1454, T = 293(2) K.
Public Mental Health – Was ist das?
Authors: Riedel-Heller Steffi , Reininghaus Ulrich , Schomerus Georg
Published: September 2023

Psychische Störungen sind häufig und folgenschwer. Die psychische Gesundheit spielt eine wichtige Rolle für die Bevölkerungsgesundheit. Der Beitrag beschreibt das aktuelle Verständnis von Public Mental Health und reflektiert die wachsende Bedeutung. Heute gibt es substanzielle Wissensbestände zu Forschungs- und Handlungsfeldern von Public Mental Health. Zukünftig muss die breite Implementierung vorhandener evidenzbasierter und kosteneffektiver Interventionen größeres Gewicht bekommen.
Psychosoziale Einflüsse auf die kognitive Gesundheit im Alter
Authors: Knecht Hanna L. , Rodriguez Francisca S.
Published: September 2023

Weltweit leben 50 Millionen Menschen mit Demenz, wobei sich diese Zahl bis 2050 verdreifachen soll. Man geht davon aus, dass eine Modifikation von Risikofaktoren eine Vielzahl an Fällen verhindern könnte. Neuste Forschungsstudien deuten die Relevanz psychosozialer Risikofaktoren an. Der Einfluss einiger bisher weniger beachteter psychosozialer Faktoren wie soziale Eingebundenheit, eine positive Lebenseinstellung, intellektuelle Stimulation und Stress wird hier diskutiert.
Determinanten der Inanspruchnahme psychischer Gesundheitsversorgung – ein integratives Modell
Authors: Peter Lina-Jolien , McLaren Thomas , Tomczyk Samuel , Muehlan Holger , Schmidt Silke , Schomerus Georg
Published: September 2023

Das Seeking Mental Health Care Model bietet eine empirisch fundierte Konzeptualisierung von internalen Faktoren im Zusammenhang mit Inanspruchnahme von professioneller Hilfe bei unbehandelten depressiven Symptomen. Es berücksichtigt Stigma und Behandlungserfahrung, deren Einflüsse auf Hilfesuche durch Überzeugungen, Wissen sowie Selbstwirksamkeit vermittelt werden. Das Modell bietet eine Grundlage für multifaktorielle Anti-Stigma Arbeit, sollte aber um externe und strukturelle Einflüsse erweitert werden.
Surveillance der psychischen Gesundheit Studierender an Hochschulen
Authors: Heinrich Angela
Published: September 2023

Die Prävalenz psychischer Erkrankungen ist bei Studierenden hoch und zwischen Hochschulen ungleich verteilt. Um auf lokale Entwicklungen reagieren zu können, wird eine Surveillance an Hochschulen vorgeschlagen. Die erarbeitete Strategie beinhaltet Befragungen, die schnell die häufigsten psychischen Erkrankungen erfassen, die organisatorisch leicht durchzuführen sind, die einen Vergleich mit der Allgemeinbevölkerung und damit eine Einordnung der lokalen Lage zulassen und helfen, passende Maßnahmen zu planen.
Online-basierte Selbstmanagement-Tools und ihre Chancen für Public Health
Authors: Schladitz Katja , Weitzel Elena Caroline , Schwenke Maria , Riedel-Heller Steffi G. , Löbner Margrit
Published: September 2023

Vor dem Hintergrund der hohen Prävalenz psychischer Erkrankungen und einer großen Versorgungslücke besteht ein Bedarf an niedrigschwelligen Versorgungs- und Selbsthilfe-Optionen. Online-basierte Selbstmanagement-Tools stellen eine innovative, niedrigschwellige und kosteneffektive komplementäre Option für Prävention, Selbsthilfe, Behandlung und Nachsorge für Menschen mit psychischen Erkrankungen dar. Sie können die Versorgungssituation breiter Bevölkerungsgruppen daher nachhaltig verbessern.
Der Gemeindepsychiatrische Verbund als Public Mental Health-Instrument
Authors: Bokhof Beate , Sieberer Marcel , Schöpe Berthold , Holtmann Martin
Published: September 2023

Gegenwärtig baut die Stadt Hamm einen Gemeindepsychiatrischen Verbund auf, in dem sich wesentliche Leistungserbringer zusammenschließen. Individualität, „health for all“ und gesundheitliche Chancengleichheit stehen dabei im Mittelpunkt. So werden Schnittstellen zwischen Öffentlichem Gesundheitsdienst und Public Mental Health genutzt, umfassende Hilfen für psychisch Kranke mit komplexen Hilfebedarfen koordiniert und Netzwerke für Betroffene, Angehörige und Leistungserbringer gestärkt (Abbildung 1).
Allianzbildung im indopazifischen Bereich – Streitkräfteintegration und erweiterte nukleare Abschreckung
Authors: Frühling Stephan , O’Neil Andrew
Published: September 2023

Kurzfassung

Anders als die NATO haben die US-Allianzen mit Australien, Japan und Südkorea keine Tradition der integrierten regionalen Abschreckung. Um 2010 schien sich das zu ändern, doch in der Praxis wirkten sich die neuen Abschreckungsdialoge mit Japan und Südkorea und die US-Australischen Force Posture Initiative in den folgenden zehn Jahren kaum aus. Seit 2020 zeigt sich jedoch ein deutlicher Wandel. Die US-Japanische und US-Australische Allianz treiben die Integration ihrer Streitkräftepotenziale voran, während die USA und Südkorea erstmals bei US-Nuklearoperationen kooperieren. Die Gründe für diesen Wandel sind Washingtons erhöhte Aufmerksamkeit gegenüber der Herausforderung durch China, Chinas zunehmend aggressives Verhalten sowie die Fortschritte von Nordkoreas Atom- und Raketenprogramm. Allerdings ist wie im Fall der NATO nach 2014 unklar, ob diese anscheinend radikalen Anpassungen der Herausforderung tatsächlich gerecht werden.
PD98059 protects SH-SY5Y cells against oxidative stress in oxygen–glucose deprivation/reperfusion
Authors: Zhuge Xiang-Zhen , Hu Wan-Xiang , Liu Yu-Mei , Jiang Chang-Yue , Zhang Xiao-Hua , Chen Meng-Hua , Xie Lu
Published: September 2023

Mitochondria play a key role in the cerebral ischemia-reperfusion injury. Although the extracellular signal-regulated kinase 1/2 inhibitor PD98059 (PD) is a selective and reversible flavonoid that can protect the mitochondria in a rat model of cardiac arrest/cardiopulmonary resuscitation, its role requires further confirmation. In this study, we investigated whether PD could maintain mitochondrial homeostasis and decrease reactive oxygen species (ROS) production in neuroblastoma (SH-SY5Y) cells exposed to oxygen–glucose deprivation/reperfusion (OGD/R). PD improved the mitochondrial morphology and function, reversed the increase in ROS production and cell apoptosis, and reduced total-superoxide dismutase and Mn-superoxide dismutase activities induced by OGD/R. PD decreases ROS production and improves mitochondrial morphology and function, protecting SH-SY5Y cells against OGD/R-induced injury.
Waste Assessment and Sustainable Sample Product Design in Textile
Authors: Yapıcı Sunaç Seda , Değirmenci Züleyha
Published: September 2023

With the increase in the world’s population, industrialization, and constantly developing technologies, people’s product usage habits have changed. These changes negatively affect the ecological balance. The textile sector is one of the important elements that disrupt the ecological balance and cause this problem. For this reason, precautions should be taken in the production, consumption, and waste management of textile products. In this study, sample applications of waste and recycled products and value-added products were produced to be environmentally and economically beneficial.
Electrochemical Corrosion Behavior of Thermally Sprayed Nichrome Coating on Duplex Stainless Steel
Authors: Kuruvila Roshan , Sundaresan Thirumalai Kumaran , Ahmed Farooq , Marimuthu Uthayakumar
Published: September 2023

Corrosion is a natural phenomenon that gradually deteriorates any material. Mild steel structures are quickly corroded by the sea environment, and thus protective coatings are normally used to prevent corrosion. In this study, atmospheric plasma spray (APS) and detonation gun (DGun) coatings are used to deposit nichrome on duplex stainless steel (DSS 2205). The coated samples were immersed in 3.5 % sodium chloride solution to perform the electrochemical corrosion studies. Microstructural characterization was performed to determine the severity and nature of the corrosion damage. The study shows that DGun coatings are more efficient than APS coatings when combining potentiodynamic polarization curves and electrochemical impedance spectroscopy measurements. DGun-coated samples exhibit a dense microstructure and strong antiparticle adhesion as their primary attributes. This implies that the DGun coating reduces corrosion rates, increases structural longevity, decreases maintenance expenses, and stimulates economic growth.
CCDC50 promotes tumor growth through regulation of lysosome homeostasis
Authors: Jia Penghui , Tian Tian , Li Zibo , Wang Yicheng , Lin Yuxin , Zeng Weijie , Ye Yu , He Miao , Ni Xiangrong , Pan Ji'an , Dong Xiaonan , Huang Jian , Li Chun‐mei , Guo Deyin , Hou Panpan
Published: September 2023

The maintenance of lysosome homeostasis is crucial for cell growth. Lysosome‐dependent degradation and metabolism sustain tumor cell survival. Here, we demonstrate that CCDC50 serves as a lysophagy receptor, promoting tumor progression and invasion by controlling lysosomal integrity and renewal. CCDC50 monitors lysosomal damage, recognizes galectin‐3 and K63‐linked polyubiquitination on damaged lysosomes, and specifically targets them for autophagy‐dependent degradation. CCDC50 deficiency causes the accumulation of ruptured lysosomes, impaired autophagic flux, and superfluous reactive oxygen species, consequently leading to cell death and tumor suppression. CCDC50 expression is associated with malignancy, progression to metastasis, and poor overall survival in human melanoma. Targeting CCDC50 suppresses tumor growth and lung metastasis, and enhances the effect of BRAFV600E inhibition. Thus, we demonstrate critical roles of CCDC50‐mediated clearance of damaged lysosomes in supporting tumor growth, hereby identifying a potential therapeutic target of melanoma.
Lokomobilność jako figura losu dziewiętnastowiecznego filologa (poznańskiego)
Authors:   Wydział Polonistyki, Uniwersytet Warszawski, Kobelska Adela
Published: September 2023

The article recalls the tradition of the 19th-century Polish philology in Poznań, which, although informal for the lack university structure, engaged literary scholars associated with Poznań. The original placement and local constraints – resulting mainly from the lack of university and the struggle to establish it – entailed a number of pragmatic transformations: geographical (study and work at German universities), institutional (non-academic employment of the philologists), as well as disciplinary (between classical, Slavic and Polish philology). The study case discussed in the article is the story of Hipolit Cegielski, a philologist turned into an engineer and industrialist. To define the nature of this transformation, the author proposes the category of locomobility (a forced change of location). The text argues that locomobility is a figure of fate of the nineteenth-century Poznan philologists. Thus, it also is a determining factor of pre-university literary studies in Poznań.
Magna Mater modernistów – kobiecość archetypiczna i inne aspekty boginiczności w epoce Młodej Polski
Authors:   Wydział Filologiczny, Uniwersytet Łódzki, Mikinka Aleksandra
Published: September 2023

The Great Goddess is a figure/idea/deity that has been “resurrected” again and again over the past century and a half, both in the context of various scholarly studies and Western spirituality. The popularity of the concept of the Great Goddess is analyzed from the perspective of various disciplines: psychology, anthropology, history of religion, etc. The origins of this phenomenon – the great return and vindication of the female deity in culture – lie primarily in the 19th-century literary texts and philosophical essays. The pancultural motif of Magna Mater has already captured the attention of Polish literary scholars, but the research has mainly concerned contemporary works and has concentrated primarily on the fantasy genre. Drawing in particular from the field of depth psychology, the author of the article adopts similar research methods to analyze works from the turn of the 19th and 20th centuries. She seeks to discover in them the archetype of the Great Goddess, which already at that time began to inspire female and male artists. This resulted in extremely interesting literary creations and motifs, including Polish works.
Czyje jest miasto? Kilka uwag o jednej powieści K.M. Bakowa
Authors:   Instytut Literaturoznawstwa, Uniwersytet Śląski, Bielak Tomasz
Published: September 2023

The article looks at the question of using urban studies as a set of interpretive techniques in analyzing popular literature – especially in its most popular genre – crime fiction. On the basis of K.M. Bakow’s debut novel Albatros i hiena [Albatross and hyena], set in Bielsko-Biała, the author of the article shows how the criminal intrigue is enriched by a specific way of showing urban space and how it relates to the main character, detective Ewa Orlowska. The proposed model of interpretation can be used in discussing subsequent novels by the author of Padlinożercy [Scavengers] and fits into the framework of geopoetics and text interpretation.
Crtice iz organiziranog poštanskog prometa u Lici
Authors: Šarić Davor
Published: September 2023

Povijest organiziranog poštanskog prometa u Lici, a tako i u lovinačkom kraju, usko je vezana uz Vojnu krajinu te su poštanski uredi bili smješteni u mjestima koja su odgovarala vojnim potrebama. U radu se predstavljaju rjeđi filatelistički objekti iz poštanske povijesti lovinačkog kraja u 19. stoljeću. Prvi poštanski uredi na lovinačkom području koji su bili korišteni i za vojnu i za civilnu poštu bili su Mali Halan i Sveti Rok, a kako su oba zatvorena do 1894. godine, rijetki pisani tragovi njihovog postojanja pružaju uvid u tadašnje funkcioniranje pošte kao i neke društvene običaje i procese.
The Experience of Disclosure and Concealment of One’s Mental Disorder
Authors: Gaižiūtė Indrė , Kaluževičiūtė-Moreton Greta , Klimaitė Vaiva
Published: September 2023

Although disclosure of one’s experience of mental disorders is an important factor in the recovery process, this topic is not well understood or studied in scientific research. This study seeks to describe and analyse the experience of disclosing and concealing information about mental disorders. The participants were 5 men and 5 women (age 24–53) experiencing a form of mental disorder and receiving treatment for at least one year. Data was collected through semi–structured interviews and analysed using thematic analysis. The results showed that the decision to disclose information about one’s mental disorder is motivated by the desire to make oneself feel better, the need to justify oneself, and as a way to educate others. In contrast, concealment is used as a way to avoid stigmatising reactions and inflicting discomfort in other people. Our study results reflect a tendency among the participants to be selective about the information disclosed as well as the people it is disclosed to; however, the latter aspects of disclosure are open to change throughout time. Finally, participants in the study reported the positive value of both disclosing and concealing information about their mental disorder. The results of this study contribute to a better understanding of disclosure and concealment of one’s mental disorder and may be useful for those who interact with or provide support to people with mental disorders.
K problematike vzťahu faktorov emocionalita a neuroticizmus meraných testami Hexaco a NEO-FFI
Authors: Fábry Rudolf , Vavrová Marta
Published: September 2023

The concept of Hexaco in personality research has been widely and intensively discussed in recent years. This interest is conditioned not only by the relative novelty of this approach, but also by the strong “kinship” relationship of the Hexaco concept with the currently dominant opinion in the field of personality, the Big Five concept. The relationship between Hexaco and the Big Five (NEO or OCEAN) is widely researched. Differences in the definition of individual factors in both concepts are a possible source of confusion, especially in the factors Neuroticism (NEO, abbr. N, NEO) and Emotionality (Hexaco, abbr. E, HEX). These factors are often understood alternatively (Mateu‑Mollá, 2020), which does not correspond to reality and their difference is emphasized (e.g. Záškodná & Dostál, 2016). The factors differ in the dimension of Anger/Hostility and Impulsivity, which is included in the Neuroticism factor (NEO) but not in the Emotionality factor (HEX). The definition of Neuroticism (NEO) appears to be more similar to Spielberger’s Anxiety (U, STAI), which is defined as the experience of tension, nervousness, fear, and apprehension as measured by the STAI questionnaire (Müllner et al., 1980). This slight confusion can cause difficulties in the interpretation of the obtained results of research in the field of personality psychology. On this basis, it is legitimate to expect a closer relationship (stronger correlations) between N (NEO) and U (STAI) than between E (HEX) and U (STAI). It is also questionable how the presence of Anger/Hostility and Impulsivity in the structure of N (NEO) will affect the strength of the correlation coefficients with the other two observed factors (E, HEX, and U, STAI).
A Coloring of the Plane Without Monochromatic Right Triangles
Authors: Bursics Balázs , Komjáth Péter
Published: September 2023

We give a full, correct proof of the following result, earlier claimed in [1]. If the Continuum Hypothesis holds then there is a coloring of the plane with countably many colors, with no monocolored right triangle.
Jiddu Krishnamurti and the Problem of Conscience
Authors: Chatterjee Arup K
Published: September 2023

Jiddu Krishnamurti (1895–1986) remains an enigma for philosophers, historians and lay audiences. Being chosen to be made “World Teacher” by the Theosophical Society (Adyar), Krishnamurti renounced his demi-godhood, in 1929, and went on to become a spiritual teacher. Krishnamurti’s vexed life has increasingly come under scrutiny, in the last three decades, owing to his perceived acts of immoral behavior. This correlates to the growing culture of public denunciations of acts of moral transgressions that we have witnessed particularly over the last decade. Considering the importance of the themes of conscience and morality within Krishnamurti’s “spiritual anarchy,” this paper tries to locate the absent centre of his seemingly decentered philosophy. It draws a comparative trajectory of the centrality of these themes in the lives and works of his philosophical parents, Helena P. Blavatsky and Annie Besant. The paper contends that Krishnamurti’s conception of morality and its role in human suffering needs to be examined, that his philosophy atavistically recapitulates the struggles of Blavatsky and Besant and, ultimately, that his perceived forays into unconscientious realms do not disqualify but reaffirm his crusade against the “still small voice of conscience.”
Reconstructing the Variant Generation Process of Hadith: Based on the Quantitative and the Isnād-cum-Matn Analysis
Authors: Yanagihashi Hiroyuki
Published: September 2023

This monograph is dedicated to the analysis of hadiths for the purpose of reconstructing the process of variant generation. Medieval authors seemingly did not devote many pages to the question of textual variation, certainly because they had little interest in the question of how individual hadiths were historically formed. Several contemporary researchers have shown interest in the issue of textual variation in hadith. They agree that many hadiths were reformulated since their initial circulation and aim to trace the process of reformulation with regard to individual hadiths. Methodologically, the most successful is the isnād-cum-matn analysis proposed by Harald Motzki and Gregor Schoeler. This method consists of determining whether a correlation lies between the transmission process of a hadith, obtained from the analysis of isnāds (chains of transmission), and its textual development, obtained from the examination of its matn (text), sometimes complemented by biographical sources. However, despite the existence of many excellent studies based on this method, presenting the general pattern of variant generation with accuracy is far from being achieved. This study, which contains four chapters, seeks to precisely reconstruct the process of variant generation by analyzing isnāds from various quantitative perspectives, in addition to using the isnād-cum- matn analysis.
Macro- and meso- marine debris on beaches in Khanh Hoa province, Vietnam: density, composition, and pollution indicators
Authors: Duong Thi Lim , Dao Dinh Cham , Nguyen Thi Lan Huong , Nguyen Thi Hue , Dang Tran Quan , Nguyen Thi Huong Thuy , Tran Thu Thuy , Trinh Thi Minh Trang , Pham Thi Dung , Dao Ngoc Nhiem , Nguyen Quang Bac , Duong Cong Dien
Published: September 2023

Marine debris is a prevalent problem that affects oceans and coastal regions worldwide, particularly beaches. The problem of marine litter pollution is also severe on beaches in Nha Trang. In this study, marine debris with a size ≥ 5 mm was collected at seven locations along the coastline of Nha Trang during both dry and rainy seasons, accruing a total of 4436 items. During the rainy season, most beaches had more debris than that in the dry season, and marine debris density ranged between 0.009 items/m2 to 0.418 items/m2. Results from the beach cleanliness index (CCI) assessment showed that CCI values ranged from 0.2 to 4.4 during the dry season, with beaches classified as either very clean or clean. Meanwhile, during the rainy season, CCI values ranged from 0.36 to 8.35, resulting in beaches being categorized as very clean, clean, or average. The Plastic Abundance Index (PAI) showed that the PAI ranged from 0.004 to 0.061 during the dry season, while during the rainy season, it ranged from 0.006 to 0.118. PAI values for both seasons indicated low levels of plastic debris distribution on the beaches. However, local authorities and managers need to pay attention to potential sources of pollution, such as waste from food service activities in restaurants, ports and unsustainable waste from aquaculture activities.
Atrial fibrillation in the elderly and long-livers: a retrospective analysis of the clinical profile of patients using artificial intelligence
Authors: Druzhilov M. A. , Kuznetsova T. Yu.
Published: September 2023

Aim. Retrospective analysis of the clinical characteristics of elderly patients with atrial fibrillation (AF) and long-livers in individual subjects of the Russian Federation using artificial intelligence.

Material and methods. The information was obtained from the Webiomed predictive analytics platform. The main database included 144431 patients with AF who received care in medical organizations in 6 constituent entities of the Russian Federation in the period 2016-2019. Of these, 56830 (39,3%) persons were aged ≥75 years: 47595 aged 75-89 years, 9235 aged ≥90 years.

Results. Patients with AF aged ≥75 years compared with persons aged 18-74 years were characterized by a significantly higher incidence of hypertension, type 2 diabetes, estimated glomerular filtration rate <60 ml/min/1,73 m2, heart failure and peripheral atherosclerosis, thromboembolic (TEE), atherothrombotic and hemorrhagic events. The prescription rate of anticoagulant therapy (ACT) was 29,6% and was lower (p<0,001) compared with a subgroup of people with AF aged 1874 years with a high risk of TEE (41,2%). Among patients with AF aged ≥75 years, in 9,4% of cases, no additional (in relation to age and sex) CHA2DS2-VASc points were found, and in 1/3 of individuals there was only one additional points. With an increase CHA2DS2-VASc score in these patients, the ACT prescription rate increased from 13 to 55,5%. The prescription rate of acetylsalicylic acid was 12,8%. Only 33% of people with AF aged ≥75 years who had an ischemic stroke were prescribed ACT.

Conclusion. The retrospective analysis indicates a high proportion of people aged ≥75 years in the structure of all patients with AF. This group is characterized by a significant comorbidity, a high TEE risk, hemorrhagic and atherothrombotic events. At the same time, the ACT prescription rate as of 2016-2019 in individual subjects of the Russian Federation did not meet the requirements of the clinical guidelines.
Experience of sacubitril/valsartan therapy in hypertension
Authors: Oshchepkova E. V.
Published: September 2023

The aim of the review was to analyze the antihypertensive efficacy and safety of sacubitril/valsartan combination, a representative of a new class of angiotensin receptor-neprilysin inhibitors (ARNIs), in patients with hypertension (HTN) according to clinical trials, including randomized, and meta-analyses. Randomized clinical trials conducted in different age, ethnic and clinical cohorts of HTN patients, as well as meta-analyses showed a more significant antihypertensive effect of sacubitril/valsartan compared with monotherapy with angiotensin II receptor blockers, confirmed by office blood pressure (BP) and 24-hour BP monitoring. At grade 1-2 HTN, sacubitril/valsartan showed greater reduction in systolic and diastolic blood pressure by ~5/2 mm Hg compared to valsartan or olmesartan according to 8-12-week studies. A dose-dependent effect of sacubitril/valsartan was established. A favorable experience was obtained with sacubitril/ valsartan use in various clinical variants of HTN (refractory HTN, isolated systolic HTN in the elderly, HTN in combination with heart failure, with chronic kidney disease), as well as the successful use of sac/vals in combination with other antihypertensive drugs. In long-term studies (52 weeks) in elderly patients with HTN, the positive effects of sacubitril/valsartan in reducing central aortic pressure, systolic blood pressure at night and a decrease in pulse pressure have been shown. Several meta-analyses have shown similar tolerability profiles compared to controls and no increased risk of adverse events.
Human Oropharyngeal Candidiasis: From Etiology to Current Treatment
Authors: Qadir Muhammad Imran , Bashir Hina , Ahmad Muhammad Hammad
Published: September 2023

Oral candidiasis is a common but most harmful oral cavity infection caused by yeast-like fungus, this condition is called Oropharyngeal candidiasis. There are various species of candida that are responsible for oral cavity fungal infection including mostly Candida albicans. Different candida infections may be acute and chronic. Cell-mediated immunity, humoral immunity, and granulocytes are the immune factors for the cause of this infection. Different antifungal drugs like nystatin, fluconazole, and amphotericin are used to treat oral cavity fungal infections.
EXPERIMENTAL INVESTIGATION OF HEAT TRANSFER AND PRESSURE DROP CHARACTERISTICS OF FERROFLUIDS IN THE PRESENCE OF MAGNETIC FIELD AND LAMINAR FLOW CONDITIONS
Authors: Muratçobanoğlu Burak , Mandev Emre , Ömeroğlu Gökhan , Manay Eyüphan
Published: September 2023

In this study, the heat transfer performance with forced convection of two different water-based nanofluids was investigated by applying an alternating magnetic field in a minichannel. CoFe2O4-water and MnFe2O4-water nanofluids have been prepared at 0.5 vol.% and tested. The tests were carried out in a minichannel under laminar flow conditions in the Reynolds numbers range of 300-1700. Nusselt numbers of each fluid used in the experiments were calculated and compared. At the Reynolds number of 1500, the CoFe2O4-water nanofluid exhibited an increase of 12% compared to pure water, while the MnFe2O4-water nanofluid showed an increase of 4%. The Nusselt number increased in both nanofluids by applying the magnetic field to nanofluids. The highest Nusselt number obtained was 9.35 for the CoFe2O4-water nanofluid in the presence of magnetic field. While this increase was more pronounced at low Reynolds numbers, a lower rate of increase was obtained at high Reynolds numbers. In addition, the use of nanofluids significantly increased the pressure drop compared to the base fluid. While an almost 100% increase in the pressure drop was observed for the CoFe2O4-water nanofluid compared to pure water, the 65% increase for the MnFe2O4-water nanofluid was maximum. At the highest Reynolds numbers, the maximum pressure drops were determined as 3.4 kPa for the CoFe2O4-water nanofluid and 3 kPa for the MnFe2O4-water nanofluid. It was also detected that the friction factor for CoFe2O4-water and MnFe2O4-water nanofluids was 80% and 40% higher, respectively, than for the base fluid.
FÓRMULAS DE APERTURA Y CIERRE EN PROCESOS DE INTERACCIÓN VERBAL EN PARLACHE
Authors: Castañeda Naranjo Luz Stella , Henao José Ignacio
Published: September 2023

En este artículo se recoge y analiza una muestra de fórmulas de apertura y de cierre de conversaciones coloquiales en parlache, utilizadas por hablantes de Medellín y su Área Metropolitana. Se ubican su función pragmática y los componentes de las expresiones con base en los aportes de Antonio Briz, María Victoria Escandell, Helena Calsamiglia y Amparo Tusón, entre otros. Los contextos fueron recopilados de testimonios escritos por jóvenes, de artículos de la prensa y de textos literarios.
ANÁLISIS DE MODALIDADES DE NARRACIÓN Y RECURSOS DEÍCTICOS EN EL CUENTO “¡DILES QUE NO ME MATEN!” DE JUAN RULFO
Authors: Quintero Ramírez Sara
Published: September 2023

En el presente artículo estudiamos las modalidades de narración y los recursos deícticos del cuento “¡Diles que no me maten!” de Juan Rulfo. Por un lado, el texto muestra una narración con diferentes modalidades: a) tercera persona que presenta a un narrador equisciente, b) monólogo a través del personaje de Juvencio Nava y c) diálogo recurrente. Por otro lado, la deixis pronominal y la léxica están presentes en la obra, pues el autor emplea catáforas para crear cierta expectativa en el lector y anáforas para evitar repeticiones y confusiones sobre los referentes de dichos elementos deícticos.
concepto de mujer en el reggaetón: análisis lingüístico
Authors: Ramírez Noreña Viviana Karina
Published: September 2023

En este artículo se analiza un corpus de tres canciones de reggaeton, desde la perspectiva del análisis crítico del discurso, donde es notorio que la mujer es utilizada por el hombre con el fin de obtener de ella una satisfacción sexual y donde el acto sexual toma gran fuerza, convirtiéndose en el tema principal en torno al cual giran las canciones. El análisis se enfoca con base en dos campos semánticos: “mujer” y “sexo”.
Managing Accessibility Conflicts: Importance of an Intersectional Approach and the Involvement of Experiential Experts
Authors: Mogendorff Karen
Published: September 2023

In this commentary, I reflect on how digital communication technology and products are both an opportunity and a threat to the inclusion of disabled people. Drawing on my personal and professional experiences with research and user‐led empowerment projects, I argue that a life course intersectional approach, together with early involvement of disabled people in technology and product development, may prevent accessibility conflicts and further participation and inclusion.
Shaping the New Vistula Spit Channel: Political, Economic, and Environmental Aspects
Authors: Breś Justyna , Lorens Piotr
Published: September 2023

In September 2022, the new shipping channel in Poland was opened for service. It connects the Port of Elbląg and the Gdańsk Bay in Poland, cutting through the Vistula Spit and the Vistula Lagoon. It was intended to enable direct access to the Baltic Sea from the Port of Elbląg without crossing Russian territory. Originally conceptualized decades ago, it has taken its final shape only recently. Its construction was associated with several issues, including economic, political, and environmental ones. But at the same time, the rationale of its construction has to be confronted with the analysis of the long-term consequences for the city's economy and the environment of the Vistula Lagoon. Many of these issues are presented and discussed in the article, along with some initial conclusions regarding future opportunities and threats associated with operational and maintenance-related issues.
HİZMETKÂR LİDERLİK DAVRANIŞI İLE ÖRGÜT SAĞLIĞI VE YAŞAM DOYUMU ARASINDAKİ İLİŞKİ
Authors: Öter Ömer Murat , Dağlı Abidin
Published: September 2023

Hizmetkâr liderlik, liderlerin takipçilerine hizmet etmesi ve kendi ihtiyaçlarından ziyade astlarının ihtiyaçlarına odaklanması gerektiği ilkesini içeren çağdaş bir liderlik teorisidir. Hizmetkâr liderler bir rol model olarak hizmet eder, güven uyandırır, bilgi verir, geri bildirim ve kaynak sağlar. Öte yandan bir örgütün varoluş nedeni olan amaçlarına ulaşması, her şeyden önce o örgütün sağlıklı olmasına bağlıdır. Sağlıklı bir örgüt, insanların kalmak ve çalışmak istedikleri bir örgüttür. Sağlıklı örgütlerde işgörenler adeta kendilerini örgütlerine adamış, istekli ve başarılı olacaklarına inanan kimselerdir. İşgörenler, çalıştıkları örgütlerle gurur duyarlar, örgüt içinde yararlı ve etkilidirler. Yaşam doyumu, bireyin kendisinin belirlediği ölçütler doğrultusunda yaşamının genel bir değerlendirmesi, hayata dair inanç ve değerlendirmelerinin toplamı olarak ifade edilebilir. Bu çalışmanın amacı, okul müdürlerinin hizmetkâr liderlik davranışları ile okulun örgüt sağlığı ve öğretmenlerin yaşam doyumu arasındaki ilişkiyi öğretmen algılarına dayalı olarak saptamaktır. Araştırma ilişkisel tarama modelinde tasarlanmış nicel bir çalışmadır. Araştırmanın örneklemini, basit tesadüfi örnekleme yöntemi ile seçilen Mardin merkez ve bağlı ilçelerdeki ilkokullarda görev yapan 542 öğretmen oluşturmaktadır. Çalışmada veriler Hizmetkâr Okul Liderliği, Örgüt Sağlığı ve Yaşam Doyumu ölçekleri kullanılarak elde edilmiştir. Öğretmenlerden elde edilen veriler korelasyon analizi tekniğiyle incelenmiştir. Çalışma sonucunda, okul müdürlerinin hizmetkâr liderlik davranışı ile okulun örgüt sağlığı ve öğretmenlerin yaşam doyumu arasında pozitif yönde ve orta düzeyde anlamlı bir ilişki olduğu saptanmıştır.
Monitoring of Local Earthquakes in Haiti Using Low-Cost, Citizen-Hosted Seismometers and Regional Broadband Stations
Authors: Paul Sylvert , Monfret Tony , Courboulex Françoise , Chèze Jérôme , Calais Eric , Julien Symithe Steeve , Deschamps Anne , Peix Fabrice , Ambrois David , Martin Xavier , St Fleur Sadrac , Boisson Dominique
Published: September 2023

Seismic monitoring in Haiti is currently provided by a mixed network of low-cost Raspberry Shake (RS) seismic stations hosted by citizens, and short-period and broadband stations located mainly in neighboring countries. The level of earthquake detection is constantly improving for a better spatio-temporal distribution of seismicity as the number of RS increases. In this article, we analyze the impact of the quality of the signals recorded by the RS—low-cost seismometers with the smallest magnitude that the network can detect by studying the ambient noise level at these stations. Because the RS stations are installed as part of a citizen-science project, their ambient noise estimated by the power spectral density (PSD) method often shows a high-noise level at frequencies above 1 Hz. In the near field (<50 km), we show that the network detects seismic events of local magnitude on the order of 2.2 with signal-to-noise ratios (SNRs) greater than 4. Improving the network detection threshold requires densifying the network with more RS stations in locations that are less noisy, if possible. In spite of these limitations, this mixed network has provided near-field data essential to rapidly understand the mechanism of the mainshock of the 14 August 2021 Mw 7.2 earthquake, to monitor its sequence of aftershocks in near-real time, and to monitor background seismicity in Haiti on a routine basis.
On ‘Anti-Speciesism’ as an Aim in Education
Authors: Swope Kelly M. S.
Published: September 2023

In this reply to the special issue 'Animals in Education', Kelly Swope raises two challenges to the consensus that ‘speciesism’ is the problem for which ‘anti-speciesist education’ is the solution. The first, which Swope calls the indoctrination challenge, comes out of his engagement with Kai Horsthemke’s article, in which the author defends the meaningfulness – and by extension, the pedagogical potency – of the term speciesism against several objections. The second, which Swope calls the alienation challenge, addresses a moment in Reingard Spannring’s article in which the author attempts an analogical argument that reveals the difficulty of grounding ‘critical animal pedagogy’ in a critique of speciesism. After offering these challenges, Swope concludes that organized educational interventions aimed at moving human-animal relations in a liberatory direction should shift their focus from undoing speciesism to studying how our world as currently structured prevents both human beings and nonhuman animals from growing up and flourishing.
Functioning of the Alpha Generation – Challenges and Hazards. The Role of Media Education in the Formation of the New Generation
Authors: Dacka Monika
Published: September 2023

The aim of the article is to present the specifics of the functioning of the Alpha generation and to show the importance of undertaking media education by the family and school environment in order to maintain the digital hygiene of this generation. The article is theoretical in nature and covers the characteristics of the Alpha generation, including the presentation of the strengths and weaknesses of this generational group. An important part is the presentation of the importance of media education for shaping the right attitudes, thinking, reasoning, and values of the younger generation. Today’s children are sometimes described as the touchscreen generation or the first generation to be born into mediatized home environments. From an early age, they use screen media (televisions computers, smartphones, tablets, or computer games). The availability of technological achievements undoubtedly affects children’s development in the emotional, social, and motivational spheres. The considerations undertaken show, on the one hand, the potential of the young generation, their needs, possibilities, and the specificity of functioning, and, on the other, indicate the legitimacy of undertaking media education. The aim of good media education should also be to develop empathy, self-reliance, kindness, and self-control as well as to arouse intellectual curiosity. Shaping proper digital hygiene habits should be one of the most important tasks of the modern education process. The proper use of smart technological devices can contribute to the development of the cognitive, linguistic, and social skills of the youngest.
Telling the World: Adults as Intermediaries in Reading Contemporary Children’s Literature
Authors: Gromysz Jowita
Published: September 2023

The aim of the article is to describe the contemporary function and role of an adult reader as a mediator in a young child’s contact with a book. The specificity of children’s literature in the context of literary communication and contemporary education was discussed. It shows what competencies are required from an adult to read picture books and stories about difficult situations in a child’s life together with a child. Selected literary examples illustrate that books for the youngest require joint dialogical reading, and the adult most often assumes the function of a translator of difficult words, the depicted world, as well as the cultural, social, or political context. The article is of a review nature, the clues collected in it indicate the need for conscious and competent mediation in contemporary children’s reading by teachers, parents, and other adult participants of literary education.
From Stock Shots to Ghost Data: Tracking Audiovisual Archives about the European Union
Authors: Shen Shiming , Treleani Matteo , Compagno Dario , Winckler Marco
Published: September 2023

This paper deals with a major challenge linked to the collection of audiovisual documents within television and web archives. Looking for repeated sequences within a corpus of thousands of videos, we faced the fact that the footage we were looking for reveals itself to be reachable only as ghost data. In fact, any audiovisual sequence reused within different contexts exists conceptually as the repetition of one single visual unit, but from the point of view of the metadata tagging its occurrences, each item is a distinct document. Like a ghost, the shot is there, scattered among different places, but the metadata cannot point us to the visual form repeated, despite its evidence to the human viewer. When facing large amounts of data, to relate a visual unit to its occurrences, data analysis techniques are needed. We describe our procedures of collection and annotation, and the solutions combining qualitive work and a computer-aided approach to face this main challenge, within the research project Crossing Borders Archives (CROBORA).
Communist History Reloaded: From Digital Utopia to Lost Historical Consciousness
Authors: Gjuričová Adéla
Published: September 2023

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Forearm injury reconstruction with split-thickness skin graft: a case report
Authors: Valdes Ramos Rodolfo L. Valdes Ramos , Jimenez Yarza Miguel , Rojas Garza Jose L. , Cedillo Treviño Sandra , Ramirez Matus Angel
Published: September 2023

Nowadays, automobile accidents have become one of the leading causes of death and functional, as well as aesthetic, repercussions in the young population. These accidents often result in a significant loss of skin surface, posing a challenge for reconstructive surgeons to cover the wounds. As a result, in the last few decades, various techniques such as negative pressure therapy, partial and full-thickness skin grafts, and the use of different flaps have been implemented. This article aims to discuss the use of skin grafts for wound coverage and the differences between the two types of grafts. It will also present a case study of a 43-year-old patient who suffered trauma while driving his vehicle, resulting in an injury to his left forearm's posterior region from the level of the elbow joint to 6 cm proximal to the radiocarpal joint. The wound was covered with a partial-thickness skin graft, which showed good evolution and excellent aesthetic results.
Constraints or Opportunities?: Labor Informality and Public Investment in Shaping Debt Limits
Authors: Méndez-Vizcaíno Juan Camilo , Moreno-Arias Nicolás
Published: September 2023

This paper presents a comprehensive framework examining fiscal sustainability in developing economies. It integrates public capital, labor informality, and global liquidity shocks in a two-sector DSGE model for a small open economy, revealing their intricate interplay and nonlinear impact on State-Dependent Debt Limits. The framework highlights the significance of initial public capital levels and efficiency in determining the benefits of public investment. High informality rates erode the tax base, compromising the efficiency of public capital for fiscal purposes by weakening revenue generation relative to costs. Adverse global liquidity shocks may significantly contract the fiscal limit distribution only if they are perceived as permanent. Through model calibration and sensitivity exercises on Colombia's fiscal limit distribution, quantitative analyses shed light on underlying mechanisms. Findings challenge the frequent practice of cutting public investment in response to declining revenues, emphasizing it can actually reduce fiscal space. The framework underscores the importance of assessing fiscal policy consolidations aimed at ensuring debt sustainability and responses to global shocks using a structural model, while stressing the fiscal benefits of informality-reducing reforms.
irc_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis
Authors: Su LiQing , Nian Ying , Zhu TianJi
Published: September 2023

Objective: This paper was to investigate the effect of circ_PWWP2A-mediated miR-27b-3p/GATA3 axis on idiopathic pulmonary fibrosis (IPF). Methods: circ_PWWP2A expression in lung fibroblasts MLg2908 induced by different concentrations of TGF-β was detected. The relationship between circ_PWWP2A or GATA3 and miR-27b-3p was analyzed by RNA immunoprecipitation and dual-luciferin reporter assay. The proliferation of MLg2908 cells was determined by MTT. GATA3, α-SMA, Collagen-I, and Collagen-III in cells were detected by RT-qPCR and Western blot. The rat model of IPF induced by bleomycin (BLM) was constructed and treated with circ_PWWP2A siRNA injection. HE and Masson staining were of utility to evaluate the pathological conditions of rat lung tissue, and circ_PWWP2A, miR-27b-3p, and GATA3 levels in lung tissues were detected by RT-qPCR. Immunohistochemistry was used to detect the staining of α-SMA, collagen I, and collagen III in the lung tissues of rats. Results: circ_PWWP2A in MLg2908 cells induced by TGF-β decreased in a concentration-dependent manner. MLg2908 cells transfected with circ_PWWP2A siRNA were induced by 5 ng/ml TGF-β, decreasing circ_PWWP2A and GATA3 levels, increasing miR-27b-3p expression, and suppressing cell proliferation. The targeting relationship between circ_PWWP2A and miR-27b-3p, as well as miR-27b-3p and GATA3, was confirmed. Depleting miR-27b-3p reduced the inhibitory effect of circ_PWWP2A down-regulation on the proliferation of TGF-β-treated MLg2908 cells, accompanied by increased expression of α-SMA, Collagen 1, and Collagen 3, and increased expression of GATA3. The in vivo results showed that BLM-induced fibrosis in rat lung tissue was obvious, accompanied by increased expression of circ_PWWP2A and GATA3, decreased expression of miR-27b-3p, and deepened staining of α-SMA, collagen I, and collagen III, but circ_PWWP2A siRNA could improve these phenomena. Conclusion: Silencing circ_PWWP2A can inhibit the proliferation of lung fibroblasts induced by TGF-β through the miR-27b-3p/GATA3 axis, and reduce BLM-induced pulmonary fibrosis in rats, which may be a potential therapeutic target for IPF.