bluuebunny/crossref_metadata_2025 huggingface dataset:
DYNAMICS OF SOIL CARBON AND N, P, K NUTRIENTS ON CORN PLANTING PATTERN IN DRY LAND
Authors: Rupa Matheus , Lehar Laurensius , Mas Sri Agung I Gusti Agung
Published: June 2021

A study was conducted during two planting seasons, namely planting season 1 (PS-1) 2017/2018 and (PS-2): 2018/2019, in Oelnasi Village, Central Kupang sub-district, Kupang District, East Nusa Tenggara, Indonesia. This study aimed to evaluate the rotation pattern of maize with legumes ground covers   towards the dynamics of soil carbon and nutrients N, P, K during the two growing seasons in a dryland farming system. The experiment was designed using a randomized block design with 3 (three) treatments replicated five times. The treatments evaluated were: crop rotation patterns consisting of: without rotation (farmer practice) and rotation pattern with Phaseolus lunatus; rotation pattern with Mucuna pruriens. Legume crops planted after harvesting the food crop and allowed to grow during the dry season. Approaching the rainy season, the biomass of the legume crop is returned to the land by immersing them it together with soil cultivation. Chemical fertilizers is given as an independent variables with a dose of 150 kg/ha of Urea; 100 kg/ha of SP36 and 100 kg/ha of KCL. The results showed that the rotation pattern of Mucuna pruriens significantly increased the soil organic C content by 50.56% and legume Phaseolus lunatus by 37.64% to PS-2. The rotation pattern of the legume covers / covered crop also significantly increased the efficiency of agronomic nutrients (N, P, and K nutrients) and maize yields during the two growing seasons. On the other hand, the farmer pattern (without rotation) showed a decrease in soil carbon to PS-2 which of course affect the efficiency of nutrient absorption.
Pergulatan Perempuan dalam Revolusi Fisik di Bali
Authors: Sukiada I Nyoman , Girindra Wardani Anak Agung Ayu , Sri Rahayu Ni Wayan
Published: June 2021

This study discusses the role of women in the Physical Revolution in Bali. The appearance of a woman in the history of politics in Bali as a leader has been seen since ancient Balinese times. However, the rise of women seems to have only been seen when the government established the Shanti Girls School. Armed with knowledge and experience in the field of organization, Balinese women are aware of the importance and meaning of independence for a nation. When the Dutch colonial government and NICA troops returned to occupy Bali in March 1946, women played a very important role in defending the independence of the Republic of Indonesia. Women played various roles, such as in the logistics sector as a member of the soup kitchen in charge of providing various types of food to the fighters; in the health sector by helping fighters who were injured and also supplying various types of medicine to the fighters; as a liaison in charge of conveying information on the state of the fighters and the state of the enemy to the leader of the fighters.
Application of the K-Means Algorithm to Segmentation of Consumer Interest in Silver Craft "Kreasi Slaka Bali"
Authors: Putri I Gusti Ayu Widiantari , Dwidasmara Ida Bagus Gede
Published: June 2021

Kreasi Slaka Bali is a company engaged in the silver handicraft sector. Each stage of the process is still done manually, starting from material preparation, handmade work, until making the packaging for delivery. Certainly, this requires more time to be able to produce an item of the same quality in each production. The need for extra time and business in product manufacturing, the company needs a marketing strategy that can be seen from consumer interest in the product. So this research discusses consumer interest based on transaction data by forming clusters based on purchases amount with other attributes, namely the product price, product size, product weight, and level of difficulty. The data used is transaction data for 2 transactions in 2019. The algorithm used is K-Means with the Elbow Method to determine the number of clusters. There are clusters of k = 5 with the cluster that has the most data in the first cluster (k = 0) with a total purchase of 193 products with an average price of US $ 69,554688.
The Effect of Feature Selection on Music Genre Classification
Authors: Giri I Nyoman Yusha Tresnatama , Putri Luh Arida Ayu Rahning
Published: June 2021

One of the things that affects classification results is the correlation of features to the class of a data. This research was conducted to determine the effect of the reduction of features (independent variable) that have the weakest correlation or have a distant relationship with the class (dependent variable). Bivariate Pearson Correlation is used as a feature selection method and K-Nearest Neighbor is used as a classification method. Results of the test showing that, 75.1% average accuracy was obtained for classification without feature selection, while using feature selection, average accuracy was obtained in the range of 75% - 79.3%. The average accuracy obtained by the selection of features tends to be higher compared to the accuracy obtained without selection of features.
PHARMACIST’S ROLE IN MEDICATION RECONCILIATION TO PREVENT THE RISK OF MEDICATION ERROR AT BALI MANDARA HOSPITAL
Authors: Sutema Ida Ayu Manik Partha , Maharjana IBN
Published: June 2021

Background: Pharmacists have an important role in implementing drug reconciliation. The implementation of drug reconciliation allows the process of identifying drug administration errors due to information gaps, which we can avoid by optimizing information as early as possible at every shift in the process of providing health services through the reconciliation process. This process is crucial, especially for groups of patients with chronic diseases who have a high risk of changing health care delivery settings. Failure to identify results in errors in administering drugs that lead to worsening clinical conditions, resulting in increased service needs and health costs. Objective: Provides information about the tendency of pharmacists who work at the UPTD Bali Mandara General Hospital to reduce drug use errors through the drug reconciliation program. Methods: Thematic analysis of structured interview results. Results: Almost all participants (6 out of 8 pharmacists) tend to be willing to be involved in the drug reconciliation process. There are three main themes of consideration that underlie the tendency of pharmacists to be willing to be involved in the drug reconciliation process, namely, related to understanding the definition, purpose, and consistency of the implementation of reconciliation. In controlling the incidence of medication errors, the biggest preventable errors through medication reconciliation are drug duplication and drug discrepancy. Conclusion: The tendency for pharmacists to be involved is good, and the tendency to control the risk of medication errors is still lacking in terms of communication and consistency in filling out by all officers.

Keywords: Pharmacist’s role, drug reconciliation, risk of medication errors
Fatal misadventure of trocariatrogenic right atrial perforation during tube thoracostomy in a patient with cardiomegaly: a case report and review of literature
Authors: Patel Parth , Jindal Rohit , Lakhera Kamal Kishor , Patni Sanjeev
Published: June 2021

Background:

Tube thoracostomy is a routine life-saving procedure with vast implications in the management of various thoracic conditions that include pleural effusion, pneumothorax, empyema, blunt, and penetrating thoracic trauma. Though a simple procedure, a high rate of morbidity and mortality is associated if a complication occurs.

Case Presentation:

An intercostal chest tube was inserted by trocar method in a 47-year-old female with rheumatic heart disease associated cardiomegaly, which resulted in right atrial perforation. The patient was managed successfully by an emergency thoracotomy followed by cardiac repair surgery. Our case report demonstrates a very unusual yet life-threatening complication of a simple intervention such as intercostal chest tube insertion and highlights the management of the same. Aim of this case report is to discuss the clinical implications and literature pertaining to the iatrogenic cardiac injury during tube thoracostomy.

Conclusion:

The use of the blind method of intercostal chest drain insertion using a trocar should be discouraged, particularly in cases with dense pleural adhesions or cardiomegaly.
RESÍDUOS ELETRÔNICOS: UM ESTUDO DA GERAÇÃO E DESCARTE DE RESÍDUOS ELETRÔNICOS PELA POPULAÇÃO DA REGIÃO DE ITATIBA-SP
Authors: Zorzi Lucas , Bardi Marcelo Augusto Gonçalves
Published: June 2021

A quantidade de produtos eletrônicos vem crescendo cada vez mais em todo o mundo e a reutilização ou reciclagem desses equipamentos é indispensável para a redução da contaminação do meio ambiente e dos seres vivos. Como prática comum, a reciclagem de sucatas eletrônicas permite a recuperação de elementos que possuam algum valor econômico agregado, como metais preciosos e terras raras. Entretanto, alguns elementos ainda permanecem como rejeitos e continuam descartados indevidamente. Dessa forma, esse projeto de pesquisa pretende encontrar a situação atual de descarte do resíduo eletrônico em cidades do interior de São Paulo, buscando oferecer uma visão sustentável e uma discutição baseada aspectos de reuso e reciclagem desses componentes
AS AULAS DE CIÊNCIAS NA VISÃO DE ALUNOS E PROFESSORES DA REDE PÚBLICA E PRIVADA DE ARARAS
Authors: Silva Thainá Verena da
Published: June 2021

As aulas de Ciências podem ser diversificadas, com diferentes estratégias de ensino, porém muitas vezes isso não acontece nas escolas, por diferentes motivos. Esta pesquisa teve como objetivo entender como alunos do Ensino Fundamental II julgam ser as aulas de Ciências, comparando com as respostas de seus respectivos professores, além de identificar possíveis sugestões de melhorias no processo de ensino-aprendizagem. A pesquisa foi realizada com questionários respondidos por alunos e professores de uma escola pública e outra particular. As respostas foram analisadas e discutidas de acordo com a bibliografia, o que permitiu algumas comparações e propostas de melhorias.  Os achados da pesquisa indicaram que os alunos e professores reconhecem e aprovam a diversificação nas aulas de Ciências como fator para torna-las mais interessantes e auxiliar na construção do conhecimento.
SOME RESULTS ABOUT GENERALIZED SEMIDERIVATIONS IN 3-PRIME NEAR-RINGS
Authors: BOUA A. , ALI A. , ABDELWANIS A. Y.
Published: June 2021

The purpose of this paper is to extend some results concerning generalized derivations to generalized semiderivations of 3-prime near rings.
Effect of blue laser on viability of Proteus mirabilis
Authors: Funjan Mawada M.
Published: June 2021

The usage of blue laser has been considered as a therapeutic approach to prohibit the viability of bacterial species, but there is no agreement about optimum parameters to be used. The aim of this project is to study the influence of blue laser (450 nm) on the viability of the gram-negative bacteria  Proteus mirabilis isolated from burn wounds, using different exposure times (i.e. doses) in vitro. Seventy swab samples were collected from burn wounds of patients admitted to the burns unit in AL-Yarmouk teaching hospital in Baghdad, during the period from June to August 2019. The Bacteria were isolated and identified depending on their culture characteristics, biochemical tests, gram staining, and morphology, being finally confirmed by API 20E Test System. By using the disk diffusion method, susceptibility of the isolates to 12 different antibiotics was examined. One isolate of P. mirabilis was elected according to susceptibility to all antibiotics used.  To prepare bacterial solution, P. mirabilis was mixed with normal saline solution. Dilution of 10-6 cell/ml for p. mirabilis was selected from other serial dilutions. A number of colonies and colony forming units (CFUs/ml) were achieved and correlated to controls.  P. mirabilis was irradiated by blue diode laser (450 nm, 500mw) and exposed to different doses (24, 48, 72, 96, 120J/cm2) corresponding to respective exposure times (4, 8,12,16,20 minutes). The results of antibiotic susceptibility test indicate that the entire isolates of P. mirabilis were multidrug resistant. With the increase in laser dose (exposure times), the number of colonies and  CFUs/ml were reduced, reaching a highest inhibition in CFU/ml  at exposure time of  20 minutes, i.e. a dose of 120J/cm2 , with  irradiance of 0.1 watt/ cm2. No significant reduction was recorded in CFU/ml   at exposure time of 4 min (a dose of 24J/cm2). As a conclusion, the blue laser irradiation at wavelength of 450 nm and 500mw had antibacterial effects on P. mirabilis isolated from burn wounds with irradiance of 0.1watt/cm2 in vitro, as evidenced by the effective reduction in the viability of bacteria at a dose of 120J/cm2 corresponding to exposure time of 20 minutes.
Cocreando sustentabilidad humana desde la participación: la experiencia de la Universidad Veracruzana
Authors: Sánchez Velásquez Lázaro Rafael , Rodríguez Audirac Leticia , Vargas Madrazo Enrique , Pensado Fernández José Antonio , Escalona Aguilar Miguel Ángel , Rivera Landa Maritza , Pascal Houbron Eric , Hernández Velasco Eric , Serrano Pérez Ester Belén , Chang Ramírez Isis , Ortega Solís Rafael , Buendía Díaz Víctor Hugo , Cervantes Herrera María José , Ruiz Cervantes Édgar Eduardo , Castro Montoya Martha Delia , Carmona García Zayda Selena , Noriega Armella María Isabel , Grajeda Olvera Adriana , Olivares Pozos Carmen Guadalupe , Veliz Cortés Margarita , Moreno Quirós Roberto Carlos , Silva Mar María de los Ángeles , García García Griselda , Corona García Magaly , Leal Ascencio Teresa , Remess Pérez Miriam , Cruz Aburto Erika Jaquelin , Garibay Pardo Leticia , Grajeda Olvera Adriana , González López Gloria
Published: June 2021

Este libro es producto de la labor y participación de muchas personas de la comunidad universitaria de la Universidad Veracruzana. Es un intento para documentar todo el trabajo que coordinó la Coordinación Universitaria para la Sustentabilidad, entre agosto del 2010 y agosto del 2016. Desarrollamos en los capítulos, principalmente, nuestra filosofía de trabajo; la organización horizontal, participativa y co-diseñada; la articulación entre una sustentabilidad sustantiva y el quehacer universitario; así como la puesta en marcha de la congruencia entre praxis, la reflexión y pensamiento, y el diálogo, este último como una de las herramientas más importantes para transitar hacia la sustentabilidad humana.
Advantages and disadvantages of using helicopters for air medical evacuation of victims with traumas (literature review)
Authors: Shapkin Yu. G. , Seliverstov P. A.
Published: June 2021

Relevance. To date, there are no clear criteria and optimal logistic conditions for the use of helicopters for the air medical evacuation of injured victims from the scene and from the emergency zone.Intention. To consider modern scientific views on the problem of using helicopters for air medical evacuation of victims from the place of injury.Methodology. PubMed database and eLIBRARY.ru platform were searched for publications from 2015 to 2020.Results and Discussion. The advantages of air ambulance evacuation by helicopters include shorter prehospital time, delivering victims from hard-to-reach areas directly to high-level trauma centers, and provision of extended prehospital care by highly qualified air medical teams. The use of helicopters is associated with risks to the life of the crew, requires significant financial costs and special equipment, and is limited by the lack of landing sites, weather conditions and at night. The effectiveness of the use of air ambulance helicopters depends on geographic and demographic factors, the level of injuries, the state of the road network in the region, the remoteness of ambulance stations, helicopter bases and trauma centers, the degree of interaction between rescue services and hospital specialists.Conclusion. The evacuation of casualties from the scene of the accident by helicopters of medical aviation can significantly reduce mortality in case of severe injuries.
PRODUK KARYA ANDRE SURYAMAN DI YOGYAKARTA DALAM KONTEKS UPCYCLE
Authors: Sutapa Widasapta , Sunarya Yan Yan , Hutama Krishna
Published: June 2021

AbstractThe concept of upcycle regeneration of a product is a creative activity to reuse products that are discarded, with the aim of becoming a sustainable and durable product. This research tries to study Natural House products by Andre Suryaman in Yogyakarta; it’s a retail that sells furniture products that use used bicycle components as the main ingredient. The research aims to identify whether Andre Suryaman's products have run the upcycle design regeneration concept. With qualitative research methods, the results of the analysis show that Andre Suryaman's products have fulfilled several points of the upcycle concept even though the results are not yet optimal, due to finishing factors that are not yet environmentally friendly. AbstrakKonsep regenerasi suatu produk secara upcycle merupakan kegiatan kreatif penggunaan kembali barang bekas dalam mengurangi produk yang dibuang dengan tujuan menjadi produk yang berkelanjutan dan tahan lama. Penelitian ini mencoba mempelajari produk Natural House karya Andre Suryaman di Yogyakarta; yaitu produk furnitur yang menggunakan komponen sepeda bekas sebagai bahan utamanya. Penelitian bertujuan untuk mengidentifikasi apakah produk karya Andre Suryaman sudah menjalankan konsep regenerasi desain secara upcycle. Dengan penelitian metode kualitatif, hasil analisis menunjukkan bahwa produk karya Andre Suryaman sudah memenuhi beberapa poin dari konsep upcycle walaupun hasilnya belum maksimal, dikarenakan faktor finishing yang belum ramah lingkungan.
KAJIAN AKSESIBILITAS UNTUK PENYANDANG DISABILITAS PADA STASIUN MRT JAKARTA
Authors: A.W.K Alfonsus Liguori , Syarief Achmad , Rudyanto Ganal
Published: June 2021

Accessibility Study for Persons with Disabilities at Jakarta MRT Station. Public transportation is the community’s need for daily mobility. The existence of public transportation is very important, especially for city development, because it can reduce traffic congestion. DKI Jakarta, as the capital of Indonesia, is a densely populated city that has traffic congestion problems. The problem of traffic congestion in Jakarta requires an appropriate and smart solution. In 2019, the city of Jakarta had a new public transportation breakthrough namely the Jakarta MRT, short for Moda Raya Integrated Jakarta (English: Jakarta Mass Rapid Transit). It is important to realize, public transportation users are not only people with normalphysical condition, but also by people with disabilities. The Jakarta MRT, as a new public transportation in Jakarta, has already paid attention to special disability facilities. The purpose of this study is to find outhow the design of disability facilities provided by the Jakarta MRT, and to determine the effectiveness of the design of the Jakarta MRT disability facilities when used by persons with disabilities. AbstrakKajian Aksesibilitas untuk Penyandang Disabilitas pada Stasiun MRT Jakarta. Transportasi umum merupakan kebutuhan masyarakat untuk melakukan mobilitas sehari-hari. Keberadaan transportasi umum sangat penting, khususnya bagi perkembangan kota, karena dapat mengurangi kemacetan lalu lintas. DKI Jakarta, sebagai ibu kota Indonesia merupakan kota padat penduduk yang memiliki masalah kemacetan lalu lintas. Masalah kemacetan di Jakarta memerlukan solusi yang tepat dan cerdas. Tahun 2019, kota Jakarta memiliki terobosan transportasi umum baru yaitu MRT Jakarta, singkatan dari Moda Raya Terpadu Jakarta(bahasa inggris: Jakarta Mass Rapid Transit). Perlu disadari, pengguna transportasi umum bukan hanya masyarakat dengan fisik normal, namun juga oleh penyandang disabilitas. MRT Jakarta, sebagai transportasi umum baru di Jakarta, sudah memperhatikan fasilitaskhusus disabilitas. Tujuan penelitian ini yaitu untuk mengetahui bagaimana desain fasilitas disabilitas yang disediakan oleh MRT Jakarta, serta mengetahui tingkat efektivitas desain fasilitas disabilitas MRT Jakarta ketika digunakan oleh penyandang disabilitas.
KAJIAN SEMIOTIKA KONOTASI ORNAMEN BETAWI GIGI BALANG
Authors: Faiz Muhammad Syukri , Saidi Acep Iwan , Rudiyanto Ganal
Published: June 2021

The connotation semiotical study of the Betawi’s gigi balang ornament discusses the meaning of the gigi balang ornament which has begun to be revived by the DKI Jakarta provincial government. The study of meaning is expected to be a guideline that an ornament is not only an art but can affect people’s lives. With the connotative semiotic method, the meaning of gigi balang does not only stop until the connotative meaning but until the mythic meaning which is held firmly by the Betawi people.
RELASI DESAIN KEMASAN PRODUK SHEET MASK TERHADAP KONSUMEN WANITA GENERASI MILENIAL
Authors: Wibowo Asrini Ayu , Jasjfi Elda Franzia , Rianinggrum Cama Juli
Published: June 2021

The Relation of Sheet Mask Product Packaging Design to Millenial Women Consumers. Indonesia’s rapidly increasing economic growth and per-capita income makes cosmetics one of the most important needs for Indonesian, especially women. The increasing population of the millennial generation is the key factor to the growth of the Indonesian cosmetics market. Nowadays, cosmetic products have become a primary need for millennial women. The purpose of this study is to find the relationship between sheetmask product packaging and the behavior of millennial women. The method used is phenomenology with five participants who already have experience in using local brand sheet masks and routinely using sheet masks with a minimum intensity of once a week. In-depth interviews in this study were used as the main method of data collection. The results showed that millennial women chose sheet mask products based on the benefits of the sheet mask products. Furthermore, millennial women choose basedon the brand after the benefits of the product. When choosing a sheet mask product, packaging design is not the main factor that influences women of millennial women. However, the packaging design isa supporting factor in choosing a sheet mask product to attract the attention of buyers and ensure the product quality.AbstrakRelasi Desain Kemasan Produk Sheet Mask Terhadap Konsumen Wanita Generasi Milenial. Pertumbuhan ekonomi dan pendapatan per-kapita Indonesia yang meningkat pesat menjadikan kosmetik sebagai salah satu kebutuhan yang penting bagi masyarakat Indonesia khususnya kaum wanita. Bertambahnya jumlah populasi penduduk generasi milenial menjadi faktor besarnya pasar kosmetik Indonesia. Saat ini, produk kosmetik telah menjadi kebutuhan primer bagi wanita generasi milenial. Tujuan dari penelitian ini adalah untuk menemukan relasi antara desain kemasan produk kosmetik sheet mask terhadap perilaku wanita generasi milenial. Metode yang digunakan adalah fenomenologi dengan partisipan sebanyak lima orang yang sudah memiliki pengalaman dalam memakai sheet mask merk lokal dan rutin memakai sheet mask dengan intensitas minimal sekali dalam seminggu. Wawancara mendalam dalam penelitian ini digunakan sebagai metode utama dalam pengumpulan data. Hasil penelitian menunjukan bahwa wanita generasi milenial memilih produk sheet mask berdasarkan manfaat dari kandungan yang diberikan oleh produk sheet mask. Selanjutnya didukung oleh brand setelah manfaat yang diberikan produk tersebut. Dalam memilih suatu produk sheet mask, desain kemasan bukanlah faktor utama mempengaruhi generasi milenial. Namun desain kemasan adalah faktor pendukung dalam memilih produk sheet mask untuk menarik perhatian dari calon pembeli dan meyakinkan bahwa produk tersebut berkualitas.
Estima corporal, insatisfacción corporal e índice de masa corporal en bailarinas de ballet y estudiantes
Authors: Cervantes Luna Brenda Sarahi , Escoto Ponce de León María del Consuelo , Camacho Ruíz Esteban Jaime
Published: June 2021

: Durante la última década, algunos autores han enfatizado en la importancia de describir y comprender aspectos positivos de la imagen corporal, por ejemplo, la estima corporal, especialmente en muestras de diferentes disciplinas artístico-estético. Por tanto, el objetivo del presente estudio fue comparar la estima corporal y la insatisfacción corporal, entre dos grupos de mujeres emparejadas por edad (bailarinas de ballet y estudiantes), y analizar la relación entre dichas variables con el índice de masa corporal (IMC). Participaron 70 mujeres, con un rango de edad de 12 a 20 años. Todas las participantes fueron pesadas y medidas, y respondieron una versión corta del Cuestionario de Imagen Corporal y la Escala de Estima Corporal. El análisis de resultados indicó que las bailarinas de ballet tienen menor IMC, menor insatisfacción corporal y mayor estima corporal hacia la condición física y preocupación por el peso, que las estudiantes. Finalmente, en el grupo de bailarinas, el IMC se asoció con la insatisfacción corporal, pero no con la estima corporal. Contrariamente, en el grupo de estudiantes, el IMC se asoció tanto con la estima corporal, como con la insatisfacción corporal. Los hallazgos del presente estudio pueden tener implicaciones en el desarrollo e implementación de estrategias que fortalezcan la estima corporal y la imagen corporal de mujeres que practican disciplinas artístico-estético.
A la sombra del éxito. El pintor Antonio Sánchez González y su actividad en la iglesia madrileña del Salvador (1801-1804)
Authors: Lorenzo Lima Juan Alejandro
Published: June 2021

This paper deals with the works of the painter from Tenerife Antonio Sánchez González in the church of El Salvador in Madrid, where he made a new fresco decoration for the pendentives of the transept and designed the main altarpiece. In addition to recalling his carrer, the study analyzes the situation of the artist before the War of Independence (1808) and the lawsuit that these actions motivated in the Royal Academy of Fine Arts of San Fernando, where they didn´t have the approval of the painters Gregorio Ferro and Mariano Salvador Maella or the architects Juan Pedro Arnal, Juan de Villanueva and Antonio López Aguado, among others
Specific Aspects in Assessing Economic Feasibility of Rare Earth Mining
Authors: Yatsenko V.
Published: June 2021

An important up-to-date feature of the resources sector development is a rapid change of types and raw material sources as well as a wide range of conditions in which the processes of mineral resources development take place. The sources of rare earth elements are not an exception because the innovative nature of their development implies the use of new knowledge, technologies and approaches. Moreover, from an economic perspective, like any investment projects, such sources of raw materials require feasibility assessment and their investment effectiveness. Based on the above, the article analyzes an economic assessment of the development of new source of rare
earth elements by the example of the Burann area of the Tomtor deposit in the Republic of Sakha (Yakutia).
Cardiomiopatia/displasia arritmogênica do ventrículo direito: relato de caso
Authors: Valle Nalu Oliveira do , Nobre Marlucia do Nascimento
Published: June 2021

Objetivo: Relatar o caso clínico de um paciente com cardiomiopatia/displasia arritmogênica do ventrículo direito, do início da apresentação clínica até ser estabelecido o diagnóstico, acompanhado em um hospital de cardiologia em uma cidade do Estado do Amazonas. Detalhamento do caso: Paciente, após iniciar quadro de palpitação, dispneia e dor torácica, buscou por unidade de pronto atendimento onde foi constatada taquicardia ventricular monomórfica e iniciada cardioversão química com amiodarona, porém evoluiu para fibrilação ventricular e parada cardiorrespiratória com retorno da circulação espontânea após manobras de reanimação cardiopulmonar e desfibrilação elétrica. Posteriormente, foi submetido a exames complementares e estes somados à história clínica e exame físico permitiu diagnosticar o paciente como portador de cardiomiopatia ∕displasia arritmogênica do ventrículo direito; como tratamento foi submetido ao implante de cardiodesfibrilador e medicado com sotalol e losartam. Considerações finais: O acompanhamento desse caso mostra uma das formas de manifestação inicial da doença, sua dificuldade diagnóstica e ainda assim a possibilidade de ser realizada sem o uso de exames invasivos.
Interfacial Water Many-body Effects Drive Structural Dynamics and Allosteric interactions in SARS-CoV-2 Main Protease Dimerization Interface
Authors: El Ahdab Dina , Lagardère Louis , Jaffrelot Inizan Theo , Célerse Frédéric , Liu Chengwen , Adjoua Olivier , Jolly Luc-Henri , Gresh Nohad , Hobaika Zeina , Ren Pengyu , G. Maroun Richard , Piquemal Jean-Philip
Published: June 2021

Following our previous work (Chem. Sci., 2021, 12, 4889 – 4907), we study the structural dynamics of the SARS-CoV-2 Main Protease dimerization interface (apo dimer) by means of microsecond adaptive sampling molecular dynamics simulations (50 microseconds) using the AMOEBA polarizable force field (PFF). This interface is structured by a complex H-bond network that is only stable at physiological pH. Structural correlations analysis between its residues and the catalytic site confirms the presence of a buried allosteric site. However, noticeable differences in allosteric connectivity are observed between PFFs and non-PFFs. Interfacial polarizable water molecules are shown to appear at the heart of this discrepancy, since they are connected to the global interface H-bond network and able to adapt their dipole moment (and dynamics) to their diverse local physico-chemical micro-environments. The water-interface many-body interactions appear to drive the interface volume fluctuations and to therefore mediate the allosteric interactions with the catalytic cavity.
Neural Language Modeling for Molecule Generation
Authors: Adilov Sanjar
Published: June 2021

Generative neural networks have shown promising results in de novo drug design. Recent studies suggest that one of the efficient ways to produce novel molecules matching target properties is to model SMILES sequences using deep learning in a way similar to language modeling in natural language processing. In this paper, we present a survey of various machine learning methods for SMILES-based language modeling and propose our benchmarking results on a standardized subset of ChEMBL database.
General Many-Body Framework for Data-Driven Potentials with Arbitrary Quantum Mechanical Accuracy: Water as a Case Study
Authors: Lambros Eleftherios , Dasgupta Saswata , Palos Etienne , Swee Steven , Hu Jie , Paesani Francesco , Lab Paesani
Published: June 2021

We present a general framework for the development of data-driven many-body (MB) potential energy functions (MB-QM PEFs) that represent the interactions between small molecules at an arbitrary quantum-mechanical (QM) level of theory. As a demonstration, a family of MB-QM PEFs for water are rigorously derived from density functionals belonging to differ- ent rungs across Jacob’s ladder of approximations within density functional theory (MB-DFT) as well as from Møller-Plesset perturbation theory (MB-MP2). Through a systematic analysis of individual many-body contributions to the interaction energies of water clusters, we demonstrate that all MB-QM PEFs preserve the same accuracy as the corresponding ab initio calculations, with the exception of those derived from density functionals within the generalized gradient approximation (GGA). The differences between the DFT and MB-DFT results are traced back to density-driven errors that prevent GGA functionals from accurately representing the underlying molecular interactions for different cluster sizes and hydrogen-bonding arrangements. We show that this shortcoming may be overcome, within the many-body formalism, by using density-corrected functionals that provide a more consistent representation of each individual many-body contribution. This is demonstrated through the development of a MB-DFT PEF derived from density-corrected PBE-D3 data, which more accurately reproduce the corresponding ab initio results.
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction
Authors: Franz Sergej , Pott Fabian , Zillinger Thomas , Schüler Christiane , Dapa Sandra , Fischer Carlo , Passos Vânia , Stenzel Saskia , Chen Fangfang , Döhner Katinka , Hartmann Gunther , Sodeik Beate , Pessler Frank , Simmons Graham , Drexler Jan Felix , Goffinet Christine
Published: June 2021

Interferon-induced transmembrane (IFITM) proteins restrict membrane fusion and virion internalization of several enveloped viruses. The role of IFITM proteins during alphaviral infection of human cells and viral counteraction strategies are insufficiently understood. Here, we characterized the impact of human IFITMs on the entry and spread of chikungunya virus and Mayaro virus and provide first evidence for a CHIKV-mediated antagonism of IFITMs. IFITM1, 2, and 3 restricted infection at the level of alphavirus glycoprotein-mediated entry, both in the context of direct infection and cell-to-cell transmission. Relocalization of normally endosomal IFITM3 to the plasma membrane resulted in loss of antiviral activity. rs12252-C, a naturally occurring variant of IFITM3 that may associate with severe influenza in humans, restricted CHIKV, MAYV, and influenza A virus infection as efficiently as wild-type IFITM3. Antivirally active IFITM variants displayed reduced cell surface levels in CHIKV-infected cells involving a posttranscriptional process mediated by one or several nonstructural protein(s) of CHIKV. Finally, IFITM3-imposed reduction of specific infectivity of nascent particles provides a rationale for the necessity of a virus-encoded counteraction strategy against this restriction factor.
Cell-autonomousToxoplasmakilling program requires Irgm2 but not its microbe vacuolar localization
Authors: Pradipta Ariel , Sasai Miwa , Motani Kou , Ma Ji Su , Lee Youngae , Kosako Hidetaka , Yamamoto Masahiro
Published: June 2021

Interferon-inducible GTPases, such as immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs), are essential for cell-autonomous immunity against a wide variety of intracellular pathogens includingToxoplasma. IRGs comprise regulatory and effector subfamily proteins. Regulatory IRGs Irgm1 and Irgm3 play important roles in anti-Toxoplasmaimmunity by globally controlling effector IRGs and GBPs. There is a remaining regulatory IRG, called Irgm2, which highly accumulates on parasitophorous vacuole membranes (PVMs). Very little is known about the mechanism of the unique localization onToxoplasmaPVMs. Here, we show that Irgm2 is important to control parasite killing through recruitment of Gbp1 and Irgb6, which does not require Irgm2 localization atToxoplasmaPVMs. Ubiquitination of Irgm2 in the cytosol, but not at the PVM, is also important for parasite killing through recruitment of Gbp1 to the PVM. Conversely, PVM ubiquitination and p62/Sqstm1 loading at later time points post-Toxoplasmainfection require Irgm2 localization at the PVM. Irgm2-deficient mice are highly susceptible toToxoplasmainfection. Taken together, these data indicate that Irgm2 selectively controls accumulation of anti-Toxoplasmaeffectors to the vacuole in a manner dependent or independent on Irgm2 localization at theToxoplasmaPVM, which mediates parasite killing.
Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrow
Authors: Sinha Garima , Ferrer Alejandra I , Ayer Seda , El-Far Markos H , Pamarthi Sri Harika , Naaldijk Yahaira , Barak Pradeep , Sandiford Oleta A , Bibber Bernadette M , Yehia Ghassan , Greco Steven J , Jiang Jie-Gen , Bryan Margarette , Kumar Rakesh , Ponzio Nicholas M , Etchegaray Jean-Pierre , Rameshwar Pranela
Published: June 2021

The challenge for treating breast cancer (BC) is partly due to long-term dormancy driven by cancer stem cells (CSCs) capable of evading immune response and resist chemotherapy. BC cells show preference for the BM, resulting in poor prognosis. CSCs use connexin 43 (Cx43) to form gap junctional intercellular communication with BM niche cells, fibroblasts, and mesenchymal stem cells (MSCs). However, Cx43 is an unlikely target to reverse BC dormancy because of its role as a hematopoietic regulator. We found N-cadherin (CDH2) and its associated pathways as potential drug targets. CDH2, highly expressed in CSCs, interacts intracellularly with Cx43, colocalizes with Cx43 in BC cells within BM biopsies of patients, and is required for Cx43-mediated gap junctional intercellular communication with BM niche cells. Notably, CDH2 and anti-apoptotic pathways maintained BC dormancy. We thereby propose these pathways as potential pharmacological targets to prevent dormancy and chemosensitize resistant CSCs.
Health research funding and its output in Pakistan
Authors: Saqib Muhammad Arif Nadeem , Rafique Ibrar
Published: June 2021

Background: Health research is very important for formulating evidence-based policies. Aims: To assess the health research funding and its output in the last 5 fiscal years (2013/14 to 2018) in Pakistan. Methods: Information about health research funding was retrieved from 3 major local agencies, the Higher Education Commission, the Pakistan Science Foundation and the Pakistan Health Research Council. Details of funding from international donors were retrieved and the number of publications was estimated from Pubmed and Pakmedinet. Results: A total of 1261.6 million Pakistan rupees (Rs) (US$ 8.4 million) was spent on health research in the last 5 fiscal years, the majority from local donors (P < 0.02). Overall funding increased from Rs 104.7 million in 2013–2014 to Rs 349.8 million 2017–2018. In publications data, 24 796 original articles were published, including 16 137 Medline and 8659 non-Medline indexed. Overall there was a gradual increase in the number of publications per year, statistically significant for Medline indexed journals. Research funding had a strong correlation (Cronbach α=0.88) with publications. Conclusion: Health research funding directly affects health research output. The funding on health research should be considered an investment rather than expenditure.
Amenorrea primaria, protocolo diagnóstico
Authors: Vera Molina Hugo Jofre , Jara Rodas Johanna Elizabeth , Jara Rodas Ivis Gregoria , Vera Jara Carlos Alejandro
Published: June 2021

La amenorrea se define como la falta de menstruación, ya sea permanente, discontinua o momentánea, resultado de alguna disfunción causada en distintos niveles, como lo puede ser a nivel genital, en los ovarios, hipófisis e hipotálamo. Cabe señalar que es un síntoma, no una enfermedad en sí misma, sin embargo, dentro de su concepto se puede abarcar una serie de patologías que perturban distintos órganos. Es uno de las razones primordiales de derivación a la consulta de ginecología y prevalece alrededor del 3% a 4%, sin tomar en cuenta los casos de menopausia, embarazo y lactancia. La amenorrea primaria puede ser causada por una variedad de desórdenes que incluyen anormalidades genéticas, alteraciones müllerianas, lesiones hipotálamo-hipofisiarias y disfunción hormonal. El diagnóstico certero de esta patología favorece un enfoque terapéutico adecuado, con el fin de atenuar o eliminar las consecuencias de esta perturbación, ya que un tratamiento tardío puede ocasionar alteraciones en el desarrollo de la personalidad o en la salud de la adolescente. La metodología de la investigación, es una revisión de tipo bibliográfica, la misma se ha apoyado en medios electrónicos como Google Académico, PubMed, como fuentes primarias para la obtención de la información. Es de suma importancia definir el agente causal de la amenorrea, ya que de esto va a depender el manejo clínico, terapéutico y preventivo. El diagnóstico correcto empieza por la realización de una historia clínica completa del paciente y el examen físico para descartar presencia o no de caracteres sexuales secundarios y por qué la amenorrea pude tener amplia variedad de causas.
Utilidad de la ecografía en la anestesia regional
Authors: Rodríguez Cabrera Daniela Natalie , Ronquillo Saavedra Alex Armando , Guerrero Cedeño Carlos Bruno
Published: June 2021

La Anestesia Regional se refiere a un grupo de técnicas realizadas a nivel del neuro-eje o nervios periféricos que ocasiona insensibilidad al dolor en el cuerpo. Esto se lleva a cabo interrumpiendo selectivamente la transmisión nerviosa sin alterar el estado de consciencia de paciente. La práctica de anestesia regional ofrece numerosas ventajas sobre la anestesia general (AG), citándose la disminución de la morbilidad y mortalidad, una analgesia posoperatoria superior, una excelente relación costo beneficio y una muy baja tasa de complicaciones. El uso de la AR en vez de la AG reduce el consumo de opioides y antieméticos, acelera la recuperación del paciente y reduce la estadía hospitalaria, incrementando la satisfacción del paciente. Gracias a la implementación de la ecografía en el procedimiento, se redescubrió las ventajas que ofrece, particularmente al visualizar en tiempo real las diferentes estructuras anatómicas, el movimiento y dirección de la aguja, la relación de las diferentes estructuras sonoanatómicas con el nervio y por último la diseminación del anestésico local en el área de punción. La metodología para esta investigación, se ha seleccionado como una revisión bibliográfica, ya que se ha recurrido a medios electrónicos como Google Académico, PubMed, Medline, entre otros. Para ubicar diferentes trabajos de investigación que documenten sobre el tema aquí estudiado, para realizar un trabajo que sintetice lo mejor posible, la información encontrada, que ayude a investigaciones futuras. En los actuales momentos tanto el ecógrafo como el anestesiólogo son un binomio, en los procesos operatorios donde sea utilizada la técnica de anestesia regional, ya que la ecografía le brinda al anestesiólogo excelentes oportunidades para seguir expandiendo sus conocimientos y accionar. La anestesia regional guiada por ecografía, garantiza una mejor evolución post operatoria, avalada por sus altas tasas de éxitos con mínimas complicaciones, que la hacen dependiendo del caso, una mejor opción que la anestesia general, y por su baja tasa de morbilidad, reduciendo el uso de opioides y antieméticos, acortando así la estancia hospitalaria, que está ligada a la reducción de costos.
Limitantes de la Educación inclusiva y su incorporación en la formación profesional de la educación superior
Authors: Sáenz Rodríguez Janina Susana , Lozano Reinoso Nubia María , Brito Guadalupe William Xavier , Arias Duque Luis Armando
Published: June 2021

En esta presente investigación hablaremos acerca de los limitantes de la educación inclusiva y su incorporación en la formación de profesionales de la educación superior, tocaremos este tema importante de manera profunda con distintos puntos como, definiendo que es la discapacidad del aprendizaje, formación profesional, sistemas educativos y que es la educación inclusiva para así tener una panorama más claro y entendible de este tema. También podemos acotar que nos fundamentamos hacia un modelo de aprendizaje eficaz e inclusivo donde no haya ningún prejuicio y la formación de profesionales sea una experiencia, basándose en no tener tabús acerca de las personas que tienen una discapacidad o una situación en sí y enseñar a todos los que nos rodean a ser inclusivos y ayudarlos a tener una mejor experiencia en la educación superior. El objetivó de nuestra investigación es analizar el procedimiento de la fortaleza de los aprendizajes básicos e impulsar la contribución, entre los estudiantes, directivos y profesores perfeccionando la disciplina y eficiencia de un modelo educativo, para examinar con detalles este tema se ha hecho un análisis de todo lo investigado. Nuestra investigación uso un enfoque cuantitativo mediante encuestas que fueron realizadas a un grupo de 15 estudiantes universitarios. Los resultados de las encuestas fueron amplios y nos acotaron informaciones importantes acerca de este tema, con esta encuesta pudimos analizar mediante las respuestas de cada estudiante las mayores limitantes de la educación superior inclusiva, además saber si conocen acerca de este tema y que opinan de él, ya que se discute y analiza desde tiempo atrás.
Device for automatic determination of inclination angles of means of mechani-zation of technological processes in agro-industrial complex
Authors: Shkrabak Roman Vladimirovich
Published: June 2021

The article describes the problem associated with the loss of stability of means of mechanization of agro-industrial processes by machine-tractor units (transport, stealing, automobile and automobile trains, combines, and lifting cranes). It is noted that this circumstance leads to overturns, accidents, injuries, fires, often accompanied by fatalities. In support of the above, information is summarized on the number of injuries among women and men in the country's agro-industrial enterprises (including lethal ones). It is noted that this is due to the fact that these units are not equipped with devices that signal, automatically notify operators operating in conditions of irregularities in the terrain of fields and roads (mountainous areas) about the achievements of maximum inclination angles, the excess of which leads to overturns. In order to eliminate these situations, a device is justified and based on extensive research, automatically signalling and visually and soundly about reaching the limit angles (for a given machine) of stability in order to take measures by the operator to prevent overturning. Equipping these machines with the proposed innovative device will eliminate the possibility of overturns and related accidents, injuries, fires, providing a socio-economic effect.
Preloading Model on Soft Soil with Inclusion Thermal Induction Vertical and Incline Types
Authors: Panjaitan Maraden , Djamaluddin A. R. , Harianto Tri , Muhiddin A. B.
Published: June 2021

Soft clay has a relatively low subgrade bearing capacity. The aim is to obtain physical values, mineralogy, mechanical strength values, values for reduction. The research method used is preloading in a test tube measuring 50×70×150 cm. Each cycle of preloading and thermal induction used a fixed load of 0.015 kg/cm². Thermal induction is given vertically and obliquely with temperature variations of 100, 200, 300, and 400 °C. The main observation point is a distance of 15 cm from the center of the induction. At 400 °C inclined induction, the water content is 17.36% (from the initial water content of 59.07%), the soil cohesion is 21.75. kN/m², the value of unconfined compressive strength is 67.72 kN/m², the highest modulus of elasticity is 4593 kN/m2, and the decrease is 5.13 cm. XRD, SEM, EDS results before heating showed mineralogy 0 (65.06%), Ca (13.30%), Na (3.64%), Mg (2.15%), Al (6.63%), Si (8.52%), Sn (0.70%) and did not change significantly after heating at 400 °C. The results after heating included 0 (58.39%), Ca (14.09%), Na (0.72%), Mg (1.16%), Al (6.63%), Si (14.72%), Sn (2.54%). The novelty obtained is to change very soft conditions became medium conditions. Doi: 10.28991/cej-2021-03091705 Full Text: PDF