bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S3 from Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth
Authors: Pearson Helen B. , Li Jason , Meniel Valerie S. , Fennell Christina M. , Waring Paul , Montgomery Karen G. , Rebello Richard J. , Macpherson Arthi A. , Koushyar Sarah , Furic Luc , Cullinane Carleen , Clarkson Richard W. , Smalley Matthew J. , Simpson Kaylene J. , Phesse Toby J. , Shepherd Peter R. , Humbert Patrick O. , Sansom Owen J. , Phillips Wayne A.
Published: April 2023

Supplementary Figure 3: Characterization of Pik3ca-mutated and Pten-deleted prostate hyperplasia and carcinoma. (A) IHC to detect the apoptotic marker Cleaved-Caspase-3 (CC3) in Wt, Pik3ca+/HR and Ptenfl/fl mice at 400 d (scale bar: 50 um). (B) Quantitation of CC3-positive nuclei in Wt, Pik3ca+/HR and Ptenfl/fl prostate epithelium (n = 3, *P <0.05 compared to Wt, or as indicated, one-way ANOVA with Tukey's multiple comparison test, ns = not significant. Error bars: SEM). (C) IHC to detect CK5 and CK8 in Pik3ca+/HR and Ptenfl/fl carcinomas (representative images from 3 prostates per genotype, scale bar: 50 um). (D) Representative IHC images to detect PTEN, mTORC1 signaling components (p-AKT Thr308, p-RPS6 Ser235/236 and p-4E-BP1 Thr37/46) and mTORC2 substrates (p-AKT Ser473 and p-NDRG1 Thr346) in Pik3ca+/HR and Ptenfl/fl hyperplastic lesions (n = 3, scale bar: 50 um). IHC quantitation for (E) p-AKT Thr308, (F) p-RPS6 Ser235/236, (G) p-4E-BP1 Thr37/46, (H) p-AKT Ser473 and (I) p-NDRG1 Thr346 in Pik3ca+/HR and Ptenfl/fl prostate hyperplastic lesions (n = 3, Error bars: SEM, *P < 0.05, unpaired, two-tailed t-test).
Figure S2 from Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth
Authors: Pearson Helen B. , Li Jason , Meniel Valerie S. , Fennell Christina M. , Waring Paul , Montgomery Karen G. , Rebello Richard J. , Macpherson Arthi A. , Koushyar Sarah , Furic Luc , Cullinane Carleen , Clarkson Richard W. , Smalley Matthew J. , Simpson Kaylene J. , Phesse Toby J. , Shepherd Peter R. , Humbert Patrick O. , Sansom Owen J. , Phillips Wayne A.
Published: April 2023

Supplementary Figure 2: Heterozygous Pik3caH1047R oncogenic mutation causes invasive prostate cancer in mice that is phenotypically distinct to Pten-null prostate cancer. (A) Sequencing cDNA isolated from PBiCre+/-;Pik3ca+/HR prostate tissue confirmed heterozygosity at known silent base changes within mutant exon 20 adjacent to exon 19, indicating recombination has occurred. (B) allele-specific PCR of cDNA isolated from PBiCre+/- prostate tissue expressing either Pik3ca+/+ (Wt) or Pik3ca+/HR alleles (as previously described (13)) revealed the presence of the mutant exon 20 in PBiCre+/-;Pik3ca+/HR prostate cDNA, but not in PBiCre+/-;Wt prostate cDNA. (C) Representative H&E images of PBiCre+/-; Wt, Pik3ca+/HR and Ptenfl/fl ventral and anterior prostate epithelium at 400 d (scale bar: 100 um). Phenotype incidence plots for PBiCre+/-; Wt, Pik3ca+/HR and Ptenfl/fl ventral (D) and anterior (E) prostate lobes. VP = Ventral prostate, AP = anterior prostate, PIN = prostate intraepithelial neoplasia. (F) IHC to detect SMA in Wt, Pik3ca+/HR and Ptenfl/fl mice at 400 d (scale bar: 50 um). (G) Quantitation of PCNA-positive nuclei in PBiCre+/-; Pik3ca+/HR and Ptenfl/fl prostate hyperplastic lesions. *P <0.001, one-way ANOVA with Tukey's multiple comparison test, n = 3. Error bars: SEM.
Supplementary text from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Authors: Drapkin Benjamin J. , George Julie , Christensen Camilla L. , Mino-Kenudson Mari , Dries Ruben , Sundaresan Tilak , Phat Sarah , Myers David T. , Zhong Jun , Igo Peter , Hazar-Rethinam Mehlika H. , Licausi Joseph A. , Gomez-Caraballo Maria , Kem Marina , Jani Kandarp N. , Azimi Roxana , Abedpour Nima , Menon Roopika , Lakis Sotirios , Heist Rebecca S. , Büttner Reinhard , Haas Stefan , Sequist Lecia V. , Shaw Alice T. , Wong Kwok-Kin , Hata Aaron N. , Toner Mehmet , Maheswaran Shyamala , Haber Daniel A. , Peifer Martin , Dyson Nicholas , Thomas Roman K. , Farago Anna F.
Published: April 2023

Text for supplement: Supplementary methods, supplementary figure legends
Figure S1 from Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth
Authors: Pearson Helen B. , Li Jason , Meniel Valerie S. , Fennell Christina M. , Waring Paul , Montgomery Karen G. , Rebello Richard J. , Macpherson Arthi A. , Koushyar Sarah , Furic Luc , Cullinane Carleen , Clarkson Richard W. , Smalley Matthew J. , Simpson Kaylene J. , Phesse Toby J. , Shepherd Peter R. , Humbert Patrick O. , Sansom Owen J. , Phillips Wayne A.
Published: April 2023

Supplementary Figure 1: PIK3CA mutations are predominantly missense mutations and PTEN mutation/loss predicts for poor prostate cancer patient survival. (A) Pie chart depicting the frequency of missense/nonsense mutations, in-frame deletions and fusion events in PIK3CA identified in the 9 prostate cancer genomic datasets assessed in Fig. 1A (3-10). (B) Kaplan-Meier plot comparing TCGA provisional prostate adenocarcinoma dataset with PTEN homozygous deletion, loss or mutation compared to the general population. PTEN age-adjusted COXPH HR: 0.47, P = 0.0026* (n = 492, samples with sequencing and CNA data only). Data was obtained from the TCGA data portal (https://tcga-data.nci.nih.gov/). PTEN copy number loss criteria; Log R ratio {less than or equal to} -0.48, probe number {greater than or equal to} 10. Silent mutations were excluded.
Supplementary Tables S3-S8 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Authors: Drapkin Benjamin J. , George Julie , Christensen Camilla L. , Mino-Kenudson Mari , Dries Ruben , Sundaresan Tilak , Phat Sarah , Myers David T. , Zhong Jun , Igo Peter , Hazar-Rethinam Mehlika H. , Licausi Joseph A. , Gomez-Caraballo Maria , Kem Marina , Jani Kandarp N. , Azimi Roxana , Abedpour Nima , Menon Roopika , Lakis Sotirios , Heist Rebecca S. , Büttner Reinhard , Haas Stefan , Sequist Lecia V. , Shaw Alice T. , Wong Kwok-Kin , Hata Aaron N. , Toner Mehmet , Maheswaran Shyamala , Haber Daniel A. , Peifer Martin , Dyson Nicholas , Thomas Roman K. , Farago Anna F.
Published: April 2023

Supplementary Tables S3-S8
Supplementary Data from Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study
Authors: Daver Naval , Garcia-Manero Guillermo , Basu Sreyashi , Boddu Prajwal C. , Alfayez Mansour , Cortes Jorge E. , Konopleva Marina , Ravandi-Kashani Farhad , Jabbour Elias , Kadia Tapan , Nogueras-Gonzalez Graciela M. , Ning Jing , Pemmaraju Naveen , DiNardo Courtney D. , Andreeff Michael , Pierce Sherry A. , Gordon Tauna , Kornblau Steven M. , Flores Wilmer , Alhamal Zainab , Bueso-Ramos Carlos , Jorgensen Jeffrey L. , Patel Keyur P. , Blando Jorge , Allison James P. , Sharma Padmanee , Kantarjian Hagop
Published: April 2023

Supplement (adjusted per last reviewer comment).
Supplementary Methods from Detection and Surveillance of Bladder Cancer Using Urine Tumor DNA
Authors: Dudley Jonathan C. , Schroers-Martin Joseph , Lazzareschi Daniel V. , Shi William Y. , Chen Simon B. , Esfahani Mohammad S. , Trivedi Dharati , Chabon Jacob J. , Chaudhuri Aadel A. , Stehr Henning , Liu Chih Long , Lim Harumi , Costa Helio A. , Nabet Barzin Y. , Sin Mandy L.Y. , Liao Joseph C. , Alizadeh Ash A. , Diehn Maximilian
Published: April 2023

Supplemental Methods
Table S2 from Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells
Authors: Radomska Katarzyna J. , Coulpier Fanny , Gresset Aurelie , Schmitt Alain , Debbiche Amal , Lemoine Sophie , Wolkenstein Pierre , Vallat Jean-Michel , Charnay Patrick , Topilko Piotr
Published: April 2023

Overview of the top 6 overrepresented KEGG pathways among upregulated transcripts in injured vs uninjured skin of Nf1-KO and control mice
Supplementary Table S4 from Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
Authors: Oser Matthew G. , Fonseca Raquel , Chakraborty Abhishek A. , Brough Rachel , Spektor Alexander , Jennings Rebecca B. , Flaifel Abdallah , Novak Jesse S. , Gulati Aditi , Buss Elizabeth , Younger Scott T. , McBrayer Samuel K. , Cowley Glenn S. , Bonal Dennis M. , Nguyen Quang-De , Brulle-Soumare Laura , Taylor Paula , Cairo Stefano , Ryan Colm J. , Pease Elizabeth J. , Maratea Kim , Travers Jon , Root David E. , Signoretti Sabina , Pellman David , Ashton Susan , Lord Christopher J. , Barry Simon T. , Kaelin William G.
Published: April 2023

Supplementary Table S4 shows synthetic lethal analysis using RIGER-E Log Fold Change 2nd Best and STARS algorithm.
Supplementary Table S2 from Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
Authors: Oser Matthew G. , Fonseca Raquel , Chakraborty Abhishek A. , Brough Rachel , Spektor Alexander , Jennings Rebecca B. , Flaifel Abdallah , Novak Jesse S. , Gulati Aditi , Buss Elizabeth , Younger Scott T. , McBrayer Samuel K. , Cowley Glenn S. , Bonal Dennis M. , Nguyen Quang-De , Brulle-Soumare Laura , Taylor Paula , Cairo Stefano , Ryan Colm J. , Pease Elizabeth J. , Maratea Kim , Travers Jon , Root David E. , Signoretti Sabina , Pellman David , Ashton Susan , Lord Christopher J. , Barry Simon T. , Kaelin William G.
Published: April 2023

Supplementary Table S2 shows Raw NGS reads and Log2 Norm Scores from Illumina sequencing of the pRB synthetic lethal screen.
Supplementary Fig. S3 from Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment
Authors: Sukumaran Sujita , Watanabe Norihiro , Bajgain Pradip , Raja Kanchana , Mohammed Somala , Fisher William E. , Brenner Malcolm K. , Leen Ann M. , Vera Juan F.
Published: April 2023

Selective enrichment process of CAR- and CAR+ transgenic sub-populations
Table S4 from Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers
Authors: Glass Jacob L. , Hassane Duane , Wouters Bas J. , Kunimoto Hiroyoshi , Avellino Roberto , Garrett-Bakelman Francine E. , Guryanova Olga A. , Bowman Robert , Redlich Shira , Intlekofer Andrew M. , Meydan Cem , Qin Tingting , Fall Mame , Alonso Alicia , Guzman Monica L. , Valk Peter J.M. , Thompson Craig B. , Levine Ross , Elemento Olivier , Delwel Ruud , Melnick Ari , Figueroa Maria E.
Published: April 2023

DMC identity and annotation for IDH2, DNMT3A, and IDH1/DNMT3A cohorts.
Table S3 (part 1) from Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers
Authors: Glass Jacob L. , Hassane Duane , Wouters Bas J. , Kunimoto Hiroyoshi , Avellino Roberto , Garrett-Bakelman Francine E. , Guryanova Olga A. , Bowman Robert , Redlich Shira , Intlekofer Andrew M. , Meydan Cem , Qin Tingting , Fall Mame , Alonso Alicia , Guzman Monica L. , Valk Peter J.M. , Thompson Craig B. , Levine Ross , Elemento Olivier , Delwel Ruud , Melnick Ari , Figueroa Maria E.
Published: April 2023

DMC identity and annotation for all clusters. This is part 1/3 (file split by columns due to upload limitations)
Supplementary Methods, Figure Legends, Table Legends, Figures S1 - S5 from Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers
Authors: Glass Jacob L. , Hassane Duane , Wouters Bas J. , Kunimoto Hiroyoshi , Avellino Roberto , Garrett-Bakelman Francine E. , Guryanova Olga A. , Bowman Robert , Redlich Shira , Intlekofer Andrew M. , Meydan Cem , Qin Tingting , Fall Mame , Alonso Alicia , Guzman Monica L. , Valk Peter J.M. , Thompson Craig B. , Levine Ross , Elemento Olivier , Delwel Ruud , Melnick Ari , Figueroa Maria E.
Published: April 2023

The supplementary methods contain a more detailed description of the analytic and experimental approach beyond the scope of the main methods section. Supplementary Figure S1. Ability of specific genomic lesions to predict epigenetic clustering. Supplementary Figure S2. ERRBS coverage. Supplementary Figure S3. Differential methylation at promoters and active enhancers. Supplementary Figure S4. DMC distribution. Supplementary Figure S5. Transcription factor binding site analysis at differentially methylated active enhancers in IDH2, DNMT3A, and IDH1/DNMT3A AMLs.
Supplementary Figures from Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models
Authors: Mata Melinda , Gerken Claudia , Nguyen Phuong , Krenciute Giedre , Spencer David M. , Gottschalk Stephen
Published: April 2023

Supplemental Figure 1: Activation of iCO molecules in T cells enhances NF-κB signaling;Supplemental Figure 2: Activation of iCO molecules enhances cytokine production in T cells;Supplemental Figure 3: CID dose-dependent IL2 production of HER2ζ.iCO T cells can be controlled by CID;Supplemental Figure 4: iCO activation enhances pro-inflammatory cytokine secretion of HER2ζ.iCO T cells;Supplemental Figure 5: Signal 1 is critical for HER2ζ.iCO T-cell effector function;Supplemental Figure 6: HER2ζ.iCO and HER2.CD28ζ T-cell lines have similar T-cell subset composition;Supplemental Figure 7: HER2ζ.iCO T cells have reduced PD-1 surface expression;Supplemental Figure 8: Recurrent tumors from HER2ζ.iCO T-cell + CID and HER2.CD28 ζ T-cell treated mice express HER2;Supplemental Figure 9: HER2ζ.iCO and HER2.CD28ζ T-cell lines have similar T-cell subset composition in vivo;Supplemental Figure 10: Anatomic location of tumors in treated mice;Supplemental Figure 11: Chemokine secretion of A549 cells, and chemokine receptor expression of T cells;Supplemental Figure 12: PD-L1 expression in tumor cell lines;Supplemental Figure 13: Generation of T-cells expressing HER2.CD28ζ.iCO;Supplemental Figure 14: iCO activation enhances expansion and pro-inflammatory cytokine secretion of HER2ζ.iCO and HER2.CD28ζ.iCO T-cells;Supplemental Figure 15: iCO activation enhances cytolytic activity of HER2ζ.iCO and HER2.CD28ζ.iCO T-cells; Supplemental Figure 16: Second CID injection eliminates recurrent tumors in 2/3 mice
Supplementary data from Notch Shapes the Innate Immunophenotype in Breast Cancer
Authors: Shen Qiang , Cohen Brenda , Zheng Weiyue , Rahbar Ramtin , Martin Bernard , Murakami Kiichi , Lamorte Sara , Thompson Patrycja , Berman Hal , Zúñiga-Pflücker Juan Carlos , Ohashi Pamela S. , Reedijk Michael
Published: April 2023

Supplementary Figures and Methods
Tables S1-S9 from Circulating Tumor DNA Genomics Correlate with Resistance to Abiraterone and Enzalutamide in Prostate Cancer
Authors: Annala Matti , Vandekerkhove Gillian , Khalaf Daniel , Taavitsainen Sinja , Beja Kevin , Warner Evan W. , Sunderland Katherine , Kollmannsberger Christian , Eigl Bernhard J. , Finch Daygen , Oja Conrad D. , Vergidis Joanna , Zulfiqar Muhammad , Azad Arun A. , Nykter Matti , Gleave Martin E. , Wyatt Alexander W. , Chi Kim N.
Published: April 2023

Supplementary Tables S1 - S9
Supplementary Figures 1-5 from MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas
Authors: Maertens Ophélia , Kuzmickas Ryan , Manchester Haley E. , Emerson Chloe E. , Gavin Alessandra G. , Guild Caroline J. , Wong Terence C. , De Raedt Thomas , Bowman-Colin Christian , Hatchi Elodie , Garraway Levi A. , Flaherty Keith T. , Pathania Shailja , Elledge Stephen J. , Cichowski Karen
Published: April 2023

Supplementary Figures and Legends
Supplementary Data from Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non–Small Cell Lung Cancer
Authors: Nangia Varuna , Siddiqui Faria M. , Caenepeel Sean , Timonina Daria , Bilton Samantha J. , Phan Nicole , Gomez-Caraballo Maria , Archibald Hannah L. , Li Chendi , Fraser Cameron , Rigas Diamanda , Vajda Kristof , Ferris Lorin A. , Lanuti Michael , Wright Cameron D. , Raskin Kevin A. , Cahill Daniel P. , Shin John H. , Keyes Colleen , Sequist Lecia V. , Piotrowska Zofia , Farago Anna F. , Azzoli Christopher G. , Gainor Justin F. , Sarosiek Kristopher A. , Brown Sean P. , Coxon Angela , Benes Cyril H. , Hughes Paul E. , Hata Aaron N.
Published: April 2023

Supplementary Figure 1-5, Supplementary Tables 1-3
Supplementary Tables from Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations with Response after Adoptive Immunotherapy for Leukemia
Authors: Berrien-Elliott Melissa M. , Cashen Amanda F. , Cubitt Celia C. , Neal Carly C. , Wong Pamela , Wagner Julia A. , Foster Mark , Schappe Timothy , Desai Sweta , McClain Ethan , Becker-Hapak Michelle , Foltz Jennifer A. , Cooper Matthew L. , Jaeger Natalia , Srivatsan Sridhar Nonavinkere , Gao Feng , Romee Rizwan , Abboud Camille N. , Uy Geoffrey L. , Westervelt Peter , Jacoby Meagan A. , Pusic Iskra , Stockerl-Goldstein Keith E. , Schroeder Mark A. , DiPersio John , Fehniger Todd A.
Published: April 2023

Supplemental patient tables (1-3) and mass cytometry reagent table (4)
Supplementary Figures 1-9 from KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition
Authors: Binkley Michael S. , Jeon Young-Jun , Nesselbush Monica , Moding Everett J. , Nabet Barzin Y. , Almanza Diego , Kunder Christian , Stehr Henning , Yoo Christopher H. , Rhee Siyeon , Xiang Michael , Chabon Jacob J. , Hamilton Emily , Kurtz David M. , Gojenola Linda , Owen Susie Grant , Ko Ryan B. , Shin June Ho , Maxim Peter G. , Lui Natalie S. , Backhus Leah M. , Berry Mark F. , Shrager Joseph B. , Ramchandran Kavitha J. , Padda Sukhmani K. , Das Millie , Neal Joel W. , Wakelee Heather A. , Alizadeh Ash A. , Loo Billy W. , Diehn Maximilian
Published: April 2023

Supplementary Figures 1-9
Supplementary Table S1 from Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy
Authors: Chou Jonathan , Quigley David A. , Robinson Troy M. , Feng Felix Y. , Ashworth Alan
Published: April 2023

Supplemental Table S1: CDK12 and CDK13 inhibitors and their properties, including in vitro potencies and structures.
Supplementary Data from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Authors: Hinze Laura , Labrosse Roxane , Degar James , Han Teng , Schatoff Emma M. , Schreek Sabine , Karim Salmaan , McGuckin Connor , Sacher Joshua R. , Wagner Florence , Stanulla Martin , Yuan Chen , Sicinska Ewa , Giannakis Marios , Ng Kimmie , Dow Lukas E. , Gutierrez Alejandro
Published: April 2023

Supplementary Figures S1-S11
Table S4 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Authors: Khazaei Sima , De Jay Nicolas , Deshmukh Shriya , Hendrikse Liam D. , Jawhar Wajih , Chen Carol C.L. , Mikael Leonie G. , Faury Damien , Marchione Dylan M. , Lanoix Joel , Bonneil Éric , Ishii Takeaki , Jain Siddhant U. , Rossokhata Kateryna , Sihota Tianna S. , Eveleigh Robert , Lisi Véronique , Harutyunyan Ashot S. , Jung Sungmi , Karamchandani Jason , Dickson Brendan C. , Turcotte Robert , Wunder Jay S. , Thibault Pierre , Lewis Peter W. , Garcia Benjamin A. , Mack Stephen C. , Taylor Michael D. , Garzia Livia , Kleinman Claudia L. , Jabado Nada
Published: April 2023

Cell type-specific markers and pathways in single-cell transcriptomics
Table S3 from H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Authors: Khazaei Sima , De Jay Nicolas , Deshmukh Shriya , Hendrikse Liam D. , Jawhar Wajih , Chen Carol C.L. , Mikael Leonie G. , Faury Damien , Marchione Dylan M. , Lanoix Joel , Bonneil Éric , Ishii Takeaki , Jain Siddhant U. , Rossokhata Kateryna , Sihota Tianna S. , Eveleigh Robert , Lisi Véronique , Harutyunyan Ashot S. , Jung Sungmi , Karamchandani Jason , Dickson Brendan C. , Turcotte Robert , Wunder Jay S. , Thibault Pierre , Lewis Peter W. , Garcia Benjamin A. , Mack Stephen C. , Taylor Michael D. , Garzia Livia , Kleinman Claudia L. , Jabado Nada
Published: April 2023

Pathway Enrichment Analysis
Figure S9 from MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
Authors: Sodir Nicole M. , Kortlever Roderik M. , Barthet Valentin J.A. , Campos Tania , Pellegrinet Luca , Kupczak Steven , Anastasiou Panayiotis , Swigart Lamorna Brown , Soucek Laura , Arends Mark J. , Littlewood Trevor D. , Evan Gerard I.
Published: April 2023

Myc de-activation triggers immediate onset of reversal of KMpdx1 tumor stroma
Figure S8 from MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
Authors: Sodir Nicole M. , Kortlever Roderik M. , Barthet Valentin J.A. , Campos Tania , Pellegrinet Luca , Kupczak Steven , Anastasiou Panayiotis , Swigart Lamorna Brown , Soucek Laura , Arends Mark J. , Littlewood Trevor D. , Evan Gerard I.
Published: April 2023

Myc de-activation triggers regression of KMp48 pancreatic tumors
Figure S7 from MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
Authors: Sodir Nicole M. , Kortlever Roderik M. , Barthet Valentin J.A. , Campos Tania , Pellegrinet Luca , Kupczak Steven , Anastasiou Panayiotis , Swigart Lamorna Brown , Soucek Laura , Arends Mark J. , Littlewood Trevor D. , Evan Gerard I.
Published: April 2023

Myc directly induces PD-L1/CD274 gene expression in KMpdx1 pancreatic epithelial cells
Figure S6 from MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
Authors: Sodir Nicole M. , Kortlever Roderik M. , Barthet Valentin J.A. , Campos Tania , Pellegrinet Luca , Kupczak Steven , Anastasiou Panayiotis , Swigart Lamorna Brown , Soucek Laura , Arends Mark J. , Littlewood Trevor D. , Evan Gerard I.
Published: April 2023

PD-L1 blockade abrogates Myc-induced T cell exclusion from KMp48 tumors
Supplementary Table 3 from Targeting HER2 with Trastuzumab Deruxtecan: A Dose-Expansion, Phase I Study in Multiple Advanced Solid Tumors
Authors: Tsurutani Junji , Iwata Hiroji , Krop Ian , Jänne Pasi A. , Doi Toshihiko , Takahashi Shunji , Park Haeseong , Redfern Charles , Tamura Kenji , Wise-Draper Trisha M. , Saito Kaku , Sugihara Masahiro , Singh Jasmeet , Jikoh Takahiro , Gallant Gilles , Li Bob T.
Published: April 2023

. Inclusion and exclusion criteria for cohort 2d (advanced HER2-expressing non-breast/non-gastric or HER2-mutant solid tumors)
Figure S1 from MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
Authors: Sodir Nicole M. , Kortlever Roderik M. , Barthet Valentin J.A. , Campos Tania , Pellegrinet Luca , Kupczak Steven , Anastasiou Panayiotis , Swigart Lamorna Brown , Soucek Laura , Arends Mark J. , Littlewood Trevor D. , Evan Gerard I.
Published: April 2023

MycERT2 expression in pancreata of Mpdx1 and Mp48 mice is at a level comparable to that of endogenous c-Myc in proliferating neonatal pancreas
Supplementary Table 8 from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities
Authors: Kelly Marcus R. , Kostyrko Kaja , Han Kyuho , Mooney Nancie A. , Jeng Edwin E. , Spees Kaitlyn , Dinh Phuong T. , Abbott Keene L. , Gwinn Dana M. , Sweet-Cordero E. Alejandro , Bassik Michael C. , Jackson Peter K.
Published: April 2023

Table of sgRNA sequences.
Supplementary Table 1 from Pan-Cancer Efficacy of Vemurafenib in BRAFV600-Mutant Non-Melanoma Cancers
Authors: Subbiah Vivek , Puzanov Igor , Blay Jean-Yves , Chau Ian , Lockhart A. Craig , Raje Noopur S. , Wolf Juergen , Baselga José , Meric-Bernstam Funda , Roszik Jason , Diamond Eli L. , Riely Gregory J. , Sherman Eric J. , Riehl Todd , Pitcher Bethany , Hyman David M.
Published: April 2023

Supplementary Table 1
Supplementary Table 2 from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities
Authors: Kelly Marcus R. , Kostyrko Kaja , Han Kyuho , Mooney Nancie A. , Jeng Edwin E. , Spees Kaitlyn , Dinh Phuong T. , Abbott Keene L. , Gwinn Dana M. , Sweet-Cordero E. Alejandro , Bassik Michael C. , Jackson Peter K.
Published: April 2023

This table lists genes whose protein products were identified by AP/MS experiments in HEK293 cells or A549 cells on the indicated sheets. The columns are as follows. Bait: bait protein (gene-wise); Prey, prey protein (gene-wise); Background Values : NSAFs for other experiments, used to infer the background distributions as described above; Qualifier: mutation state of bait protein; FDR: false discovery rate; NSAF : the log10 transform of the Normalized Spectral Abundance Factor (see Methods), with greater numbers indicating stronger signals.
Table S7 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

List of top epigenetic rescuers of or sensitizers to JQ1.
Supplementary Table 1 from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities
Authors: Kelly Marcus R. , Kostyrko Kaja , Han Kyuho , Mooney Nancie A. , Jeng Edwin E. , Spees Kaitlyn , Dinh Phuong T. , Abbott Keene L. , Gwinn Dana M. , Sweet-Cordero E. Alejandro , Bassik Michael C. , Jackson Peter K.
Published: April 2023

Primers for quickchange mutagenesis of the indicated bait proteins used in AP/MS experiments.
Table S6 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

List of sgRNA Guides Used in the CRISPR Screen.
Table S4 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

Characteristics of CBF AML patient samples used in this study.
Supplementary Tables from CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade
Authors: Wang Guangchuan , Chow Ryan D. , Zhu Lvyun , Bai Zhigang , Ye Lupeng , Zhang Feifei , Renauer Paul A. , Dong Matthew B. , Dai Xiaoyun , Zhang Xiaoya , Du Yaying , Cheng Yujing , Niu Leilei , Chu Zhiyuan , Kim Kristin , Liao Cun , Clark Paul , Errami Youssef , Chen Sidi
Published: April 2023

A supplementary table of a multi-tab excel file including source data (non-NGS) and statistics
Table S2 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

Supplementary Table S2
Table S1 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

List of metabolic gene sets queried using ssGSEA on the two cohorts of patients with AML (TCGA-LAML and GSE14468).
Supplementary Data from CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade
Authors: Wang Guangchuan , Chow Ryan D. , Zhu Lvyun , Bai Zhigang , Ye Lupeng , Zhang Feifei , Renauer Paul A. , Dong Matthew B. , Dai Xiaoyun , Zhang Xiaoya , Du Yaying , Cheng Yujing , Niu Leilei , Chu Zhiyuan , Kim Kristin , Liao Cun , Clark Paul , Errami Youssef , Chen Sidi
Published: April 2023

Supplementary data file contains Supplementary Methods and Supplementary Figures S1-S11 and related figure legends
Supplementary Data from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

Supplementary Material and Methods
Figure S9 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

Effect of MTHFR impairment on response to OTX015.
Supplementary Data Table 2 from Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System
Authors: Mehta Vikas , Goel Sanjay , Kabarriti Rafi , Cole Daniel , Goldfinger Mendel , Acuna-Villaorduna Ana , Pradhan Kith , Thota Raja , Reissman Stan , Sparano Joseph A. , Gartrell Benjamin A. , Smith Richard V. , Ohri Nitin , Garg Madhur , Racine Andrew D. , Kalnicki Shalom , Perez-Soler Roman , Halmos Balazs , Verma Amit
Published: April 2023

Detailed description of deceased cohort of patients with cancer and COVID-19
Figure S7 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

MTHFR suppression does not alter AML cell response to venetoclax.
Figure S6 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

MTAP suppression modulates response to BET inhibitors.
Figure S4 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

DHFR, DHFR2, and MTHFR knockdown impairs ratios of their respective primary and end-product metabolites.
Figure S3 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

Folic acid withdrawal attenuates leukemic blast response to JQ1.
Figure S2 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

Folic acid withdrawal does not significantly affect mouse hematocrit, white blood count, and weight.
Figure S13 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

Spi1 knockdown alleviates the resistance to JQ1 mediated by folic acid withdrawal.
Figure S12 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Authors: Su Angela , Ling Frank , Vaganay Camille , Sodaro Gaetano , Benaksas Chaïma , Dal Bello Reinaldo , Forget Antoine , Pardieu Bryann , Lin Kevin H. , Rutter Justine C. , Bassil Christopher F. , Fortin Gael , Pasanisi Justine , Antony-Debré Iléana , Alexe Gabriela , Benoist Jean-François , Pruvost Alain , Pikman Yana , Qi Jun , Schlageter Marie-Hélène , Micol Jean-Baptiste , Roti Giovanni , Cluzeau Thomas , Dombret Hervé , Preudhomme Claude , Fenouille Nina , Benajiba Lina , Golan Hava M. , Stegmaier Kimberly , Lobry Camille , Wood Kris C. , Itzykson Raphael , Puissant Alexandre
Published: April 2023

Transcriptional and epigenetic changes induced by folate starvation in AML cells.
Supplementary Information from The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies
Authors: Prager Briana C. , Vasudevan Harish N. , Dixit Deobrat , Bernatchez Jean A. , Wu Qiulian , Wallace Lisa C. , Bhargava Shruti , Lee Derrick , King Bradley H. , Morton Andrew R. , Gimple Ryan C. , Pekmezci Melike , Zhu Zhe , Siqueira-Neto Jair L. , Wang Xiuxing , Xie Qi , Chen Clark , Barnett Gene H. , Vogelbaum Michael A. , Mack Stephen C. , Chavez Lukas , Perry Arie , Raleigh David R. , Rich Jeremy N.
Published: April 2023

Supplementary Information
Supplementary Data from Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade
Authors: Torrejon Davis Y. , Abril-Rodriguez Gabriel , Champhekar Ameya S. , Tsoi Jennifer , Campbell Katie M. , Kalbasi Anusha , Parisi Giulia , Zaretsky Jesse M. , Garcia-Diaz Angel , Puig-Saus Cristina , Cheung-Lau Gardenia , Wohlwender Thomas , Krystofinski Paige , Vega-Crespo Agustin , Lee Christopher M. , Mascaro Pau , Grasso Catherine S. , Berent-Maoz Beata , Comin-Anduix Begoña , Hu-Lieskovan Siwen , Ribas Antoni
Published: April 2023

Supplementary Figures
Table S2 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Authors: Singh Nathan , Lee Yong Gu , Shestova Olga , Ravikumar Pranali , Hayer Katharina E. , Hong Seok Jae , Lu Xueqing Maggie , Pajarillo Raymone , Agarwal Sangya , Kuramitsu Shunichiro , Orlando Elena J. , Mueller Karen Thudium , Good Charly R. , Berger Shelley L. , Shalem Ophir , Weitzman Matthew D. , Frey Noelle V. , Maude Shannon L. , Grupp Stephan A. , June Carl H. , Gill Saar , Ruella Marco
Published: April 2023

Classification of KEGG hsa04210 gene set to develop intrinsic and extrinsic death receptor gene sets
Figure S7 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Authors: Singh Nathan , Lee Yong Gu , Shestova Olga , Ravikumar Pranali , Hayer Katharina E. , Hong Seok Jae , Lu Xueqing Maggie , Pajarillo Raymone , Agarwal Sangya , Kuramitsu Shunichiro , Orlando Elena J. , Mueller Karen Thudium , Good Charly R. , Berger Shelley L. , Shalem Ophir , Weitzman Matthew D. , Frey Noelle V. , Maude Shannon L. , Grupp Stephan A. , June Carl H. , Gill Saar , Ruella Marco
Published: April 2023

Death receptor gene expression is associated with clinical outcomes.
Figure S6 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Authors: Singh Nathan , Lee Yong Gu , Shestova Olga , Ravikumar Pranali , Hayer Katharina E. , Hong Seok Jae , Lu Xueqing Maggie , Pajarillo Raymone , Agarwal Sangya , Kuramitsu Shunichiro , Orlando Elena J. , Mueller Karen Thudium , Good Charly R. , Berger Shelley L. , Shalem Ophir , Weitzman Matthew D. , Frey Noelle V. , Maude Shannon L. , Grupp Stephan A. , June Carl H. , Gill Saar , Ruella Marco
Published: April 2023

GSEA of transcriptomic and epigenomic sequencing of CART19 cells exposed to either WT or BIDKO Nalm6.
Figure S4 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Authors: Singh Nathan , Lee Yong Gu , Shestova Olga , Ravikumar Pranali , Hayer Katharina E. , Hong Seok Jae , Lu Xueqing Maggie , Pajarillo Raymone , Agarwal Sangya , Kuramitsu Shunichiro , Orlando Elena J. , Mueller Karen Thudium , Good Charly R. , Berger Shelley L. , Shalem Ophir , Weitzman Matthew D. , Frey Noelle V. , Maude Shannon L. , Grupp Stephan A. , June Carl H. , Gill Saar , Ruella Marco
Published: April 2023

Persistent antigen exposure resulting from impaired T cell cytotoxicity machinery results in progressive CART19 dysfunction.
Figure S3 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Authors: Singh Nathan , Lee Yong Gu , Shestova Olga , Ravikumar Pranali , Hayer Katharina E. , Hong Seok Jae , Lu Xueqing Maggie , Pajarillo Raymone , Agarwal Sangya , Kuramitsu Shunichiro , Orlando Elena J. , Mueller Karen Thudium , Good Charly R. , Berger Shelley L. , Shalem Ophir , Weitzman Matthew D. , Frey Noelle V. , Maude Shannon L. , Grupp Stephan A. , June Carl H. , Gill Saar , Ruella Marco
Published: April 2023

Persistent exposure to WT leukemia causes progressive CART19 dysfunction.
Figure S1 from Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Authors: Singh Nathan , Lee Yong Gu , Shestova Olga , Ravikumar Pranali , Hayer Katharina E. , Hong Seok Jae , Lu Xueqing Maggie , Pajarillo Raymone , Agarwal Sangya , Kuramitsu Shunichiro , Orlando Elena J. , Mueller Karen Thudium , Good Charly R. , Berger Shelley L. , Shalem Ophir , Weitzman Matthew D. , Frey Noelle V. , Maude Shannon L. , Grupp Stephan A. , June Carl H. , Gill Saar , Ruella Marco
Published: April 2023

Impairment of death receptor signaling results in resistance to CART19.
Supplementary Tables S1-S6 from Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia
Authors: Pei Shanshan , Pollyea Daniel A. , Gustafson Annika , Stevens Brett M. , Minhajuddin Mohammad , Fu Rui , Riemondy Kent A. , Gillen Austin E. , Sheridan Ryan M. , Kim Jihye , Costello James C. , Amaya Maria L. , Inguva Anagha , Winters Amanda , Ye Haobin , Krug Anna , Jones Courtney L. , Adane Biniam , Khan Nabilah , Ponder Jessica , Schowinsky Jeffrey , Abbott Diana , Hammes Andrew , Myers Jason R. , Ashton John M. , Nemkov Travis , D'Alessandro Angelo , Gutman Jonathan A. , Ramsey Haley E. , Savona Michael R. , Smith Clayton A. , Jordan Craig T.
Published: April 2023

Supplementary Tables S1-S6 describing patient characteristics, gene lists, LSC signatures, and reagents.
Figure S2 from ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer
Authors: Huang Yun-Han , Hu Jing , Chen Fei , Lecomte Nicolas , Basnet Harihar , David Charles J. , Witkin Matthew D. , Allen Peter J. , Leach Steven D. , Hollmann Travis J. , Iacobuzio-Donahue Christine A. , Massagué Joan
Published: April 2023

Figure S2
Supplementary Table 3 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer
Authors: Amodio Vito , Yaeger Rona , Arcella Pamela , Cancelliere Carlotta , Lamba Simona , Lorenzato Annalisa , Arena Sabrina , Montone Monica , Mussolin Benedetta , Bian Yu , Whaley Adele , Pinnelli Marika , Murciano-Goroff Yonina R. , Vakiani Efsevia , Valeri Nicola , Liao Wei-Li , Bhalkikar Anuja , Thyparambil Sheeno , Zhao Hui-Yong , de Stanchina Elisa , Marsoni Silvia , Siena Salvatore , Bertotti Andrea , Trusolino Livio , Li Bob T. , Rosen Neal , Di Nicolantonio Federica , Bardelli Alberto , Misale Sandra
Published: April 2023

Supplementary Table 3
Supplementary Figure 3 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer
Authors: Amodio Vito , Yaeger Rona , Arcella Pamela , Cancelliere Carlotta , Lamba Simona , Lorenzato Annalisa , Arena Sabrina , Montone Monica , Mussolin Benedetta , Bian Yu , Whaley Adele , Pinnelli Marika , Murciano-Goroff Yonina R. , Vakiani Efsevia , Valeri Nicola , Liao Wei-Li , Bhalkikar Anuja , Thyparambil Sheeno , Zhao Hui-Yong , de Stanchina Elisa , Marsoni Silvia , Siena Salvatore , Bertotti Andrea , Trusolino Livio , Li Bob T. , Rosen Neal , Di Nicolantonio Federica , Bardelli Alberto , Misale Sandra
Published: April 2023

Supplementary Figure 3
Supplementary Figure 1 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer
Authors: Amodio Vito , Yaeger Rona , Arcella Pamela , Cancelliere Carlotta , Lamba Simona , Lorenzato Annalisa , Arena Sabrina , Montone Monica , Mussolin Benedetta , Bian Yu , Whaley Adele , Pinnelli Marika , Murciano-Goroff Yonina R. , Vakiani Efsevia , Valeri Nicola , Liao Wei-Li , Bhalkikar Anuja , Thyparambil Sheeno , Zhao Hui-Yong , de Stanchina Elisa , Marsoni Silvia , Siena Salvatore , Bertotti Andrea , Trusolino Livio , Li Bob T. , Rosen Neal , Di Nicolantonio Federica , Bardelli Alberto , Misale Sandra
Published: April 2023

Supplementary Figure 1
Supplementary Table S3 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
Authors: Clarke Matthew , Mackay Alan , Ismer Britta , Pickles Jessica C. , Tatevossian Ruth G. , Newman Scott , Bale Tejus A. , Stoler Iris , Izquierdo Elisa , Temelso Sara , Carvalho Diana M. , Molinari Valeria , Burford Anna , Howell Louise , Virasami Alex , Fairchild Amy R. , Avery Aimee , Chalker Jane , Kristiansen Mark , Haupfear Kelly , Dalton James D. , Orisme Wilda , Wen Ji , Hubank Michael , Kurian Kathreena M. , Rowe Catherine , Maybury Mellissa , Crosier Stephen , Knipstein Jeffrey , Schüller Ulrich , Kordes Uwe , Kram David E. , Snuderl Matija , Bridges Leslie , Martin Andrew J. , Doey Lawrence J. , Al-Sarraj Safa , Chandler Christopher , Zebian Bassel , Cairns Claire , Natrajan Rachael , Boult Jessica K.R. , Robinson Simon P. , Sill Martin , Dunkel Ira J. , Gilheeney Stephen W. , Rosenblum Marc K. , Hughes Debbie , Proszek Paula Z. , Macdonald Tobey J. , Preusser Matthias , Haberler Christine , Slavc Irene , Packer Roger , Ng Ho-Keung , Caspi Shani , Popović Mara , Faganel Kotnik Barbara , Wood Matthew D. , Baird Lissa , Davare Monika Ashok , Solomon David A. , Olsen Thale Kristin , Brandal Petter , Farrell Michael , Cryan Jane B. , Capra Michael , Karremann Michael , Schittenhelm Jens , Schuhmann Martin U. , Ebinger Martin , Dinjens Winand N.M. , Kerl Kornelius , Hettmer Simone , Pietsch Torsten , Andreiuolo Felipe , Driever Pablo Hernáiz , Korshunov Andrey , Hiddingh Lotte , Worst Barbara C. , Sturm Dominik , Zuckermann Marc , Witt Olaf , Bloom Tabitha , Mitchell Clare , Miele Evelina , Colafati Giovanna Stefania , Diomedi-Camassei Francesca , Bailey Simon , Moore Andrew S. , Hassall Timothy E.G. , Lowis Stephen P. , Tsoli Maria , Cowley Mark J. , Ziegler David S. , Karajannis Matthias A. , Aquilina Kristian , Hargrave Darren R. , Carceller Fernando , Marshall Lynley V. , von Deimling Andreas , Kramm Christof M. , Pfister Stefan M. , Sahm Felix , Baker Suzanne J. , Mastronuzzi Angela , Carai Andrea , Vinci Maria , Capper David , Popov Sergey , Ellison David W. , Jacques Thomas S. , Jones David T.W. , Jones Chris
Published: April 2023

Supplementary Table S3