bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYSIS OF THE IMPACT OF THE CENTRAL BANK DIGITAL CURRENCY ATTENTION INDEX ON THE VOLATILITY OF FOREIGN EXCHANGE MARKETS
Authors: Frolov Serhiy , Ivasenko Maksym , Dykha Mariia , Hrabar Vladyslav
Published: December 2023

The financial world is currently on the cusp of significant innovation, with central bank digital currencies (CBDCs) playing a key role. CBDCs are digital assets registered in centralized or decentralized accounting systems and can be exchanged for traditional forms of money. As of September 2023, 64 countries have seen active development of central bank digital currencies, including processes from development to piloting and even launch. Among the Group of Twenty (G20) countries, 19 countries are actively developing their CBDCs, of which 9 are already implementing pilot projects in this area. Over the past six months, each of these G20 countries has made notable progress by investing additional resources in developing their CBDC projects. To date, more than 130 countries, which account for almost 98% of global GDP, are actively exploring the possibilities of implementing CBDC. However, there are more and more questions about the impact of CBDC on foreign exchange markets and their volatility. Recent studies, in particular [1,2,3], indicate a potential relationship between the volatility of the index of attention to CBDC and currency markets. Thus, this work seeks to examine exactly how central bank digital currencies can affect the dynamics of currency markets, as well as how they can change the characteristics of their functioning. The specialty of this study is the application of quantitative analysis to investigate the impact of the volatility of the CBDC attention index on foreign exchange markets. The main question is whether CBDCs can change the markets' perception of news and affect the level of volatility. It is also important to determine whether the CBDC attention index is the cause of volatility in currency markets or simply reflects it. It explores the interaction between CBDC and currency markets, which are key to global financial stability and investment decisions. The aim is to examine the impact of central bank digital currencies on the behaviour of currency markets.
DIGITALIZATION IMPACT ON THE LABOUR MARKET AND SOCIAL AND LABOUR RELATIONS
Authors: Chaliuk Yuliia
Published: December 2023

. Globalization is expanding the scope of employment forms in the labour market. The digital transformation of production effects both the Economy and Employment. The production processes automation requires constant updating of knowledge and increasing the competence of employees, high readiness to adapt to new conditions and mechanisms for the formation of Social and Labour relations. Such changes affect the functioning of society, contribute to the establishment of a new level of quality of life, when people’s priorities are changed, the needs for self-realization and intellectual development become a priority by increasing the educational level, qualifications, and improving their own skills and competencies. Technological changes, on the one hand, can lead to job displacement and technological unemployment, and on the other hand, increase worker efficiency and increase their wages. These two trends are not necessarily mutually exclusive. With the advent of the digital platforms, some professions are being automated and others are being reorganized. This has led to the emergence of alternative operating mechanisms, in particular the “Gig economy” or Concert economy. Gig economy is a labour relations model based on the short-term contracts or informal agreements (Uber, Lyft, TaskRabbit, GrubHub, Postmates).
NFTs AS THE NEXT STEP IN DIGITAL ECONOMY
Authors: Hnatyshyn Maria
Published: December 2023

Non-fungible tokens (NFTs) are a type of digital asset that represents ownership or authenticity proof of a unique item using blockchain technology. Each NFT has a distinct ID, and its ownership and transaction history are recorded using blockchain technology. In other words, NFT is a way for blockchain technology to certify ownership and tradeable rights to digital assets. Unlike cryptocurrency units, they cannot be exchanged like for like. They are unique for each item and, therefore, create a new way of authenticating [1]. Text, picture, video, audio, and game items can all be copied, but the token itself cannot be copied. Tokens are stored cryptographically on a blockchain, which is an immutable ledger that facilitates the process of recording transactions and tracking assets. An immutable ledger is permanent and immune to data corruption, as once the information is recorded, it cannot be altered. These concepts are combined with the benefits of smart contracts. A smart contract is a precondition written into the code on a blockchain. If predetermined conditions are met and verified, computers execute actions like releasing funds to the appropriate parties, issuing tickets, sending notifications, etc. They are commonly used to automatically carry out an agreement, ensuring that all involved parties promptly know the result without the need for an intermediary or delays. The blockchain ledger is subsequently updated upon the culmination of the transaction [2]. NFTs enable the generation and exchange of distinctive digital assets and have the potential to create new economic opportunities and value streams. They have already shown significant potential for generating substantial returns for their holders, thus generating tangible value for both buyers and sellers.
SWOT ANALYSIS OF THE USE OF SOCIAL NETWORKS IN DIGITAL MARKETING
Authors: Zhygalo Ivan
Published: December 2023

Keeping a finger on the pulse of modern trends in the use of social networks in digital marketing is not merely an option; it's a necessity in today's dynamic digital landscape. The rapid evolution of social media platforms, user behaviors, technological advancements, and market dynamics necessitates continuous research and adaptation. Understanding and leveraging these trends are essential for businesses aiming to remain competitive, engage their target audience effectively, optimize their content strategies, and maximize return on investment. It allows for the creation of more relevant and engaging content, the identification of emerging opportunities, the mitigation of risks associated with outdated strategies, and the establishment of a strong brand presence across evolving digital platforms. Ultimately, staying informed about modern social media trends empowers businesses to stay ahead of the curve, innovate their marketing approaches, build stronger connections with their audience, and navigate the ever-changing landscape of digital marketing with agility and effectiveness.
DIGITALIZATION AS A DIRECTION OF POST-WAR RECOVERY AND DEVELOPMENT OF THE ECONOMY OF UKRAINE: PROSPECTS AND PROBLEMS
Authors: Illiashenko Sergii , Shypulina Yuliia , Illiashenko Nataliia
Published: December 2023

The war with russia caused the loss of a significant part of Ukraine's economic potential, in particular its potential subsystems: labor, productive, natural, financial, etc. This initiates the search for effective ways of post-war recovery of the national economy and ensuring its growth. Moreover, taking into account the leading role of developments of the past technological systems (third and fourth) in the economy of Ukraine, the strategies of economic recovery and growth should be directed to the concept of innovative advancement. Innovative advancement involves choosing (certainly in line with global trends in STP) one's own path of development based on the search and realization of own competitive advantages in fields of activity and markets with necessary and sufficient conditions instead repeating the path that others have already taken and gained strong positions. The fourth industrial revolution (IR4.0), the completion of the fifth and the emergence of the sixth technological order set the general trends in the development of STP. Global experience shows that in the context of the deployment of IR4.0 and the active implementation of digital informational and communicative technologies (ICT) in almost all spheres of human activity, digitization is a promising direction of innovative development of the national economy. For post-war Ukraine, digitization is becoming one of the main priorities. Digital transformations create opportunities for the functioning and development of various spheres of human activity in the conditions of the loss of a part of the production base, objects of the market and social infrastructure, withdrawal of significant territories from economic activity, etc. In particular, by transferring business operations and providing services to the Internet, forming digital labor markets, etc. However, digitalization has a certain duality. On the one hand, it creates opportunities for innovative development. On the other hand, it creates problems that can exacerbate socio-economic contradictions and cause crisis phenomena. In this way, the problem of forecasting the consequences of the digitalization of the national economy of Ukraine and developing recommendations for using favorable opportunities and countering threats is actualized.
Проблема разрешения конфликтов студенческой молодежи
в управлении образовательной средой вуза
Authors: Пискунова Виктория Валентиновна
Published: December 2023

Статья посвящена проблеме управления образовательной средой образовательной организации высшего образования посредством формирования конфликтологической компетентности обу-чающихся. Излагается анализ исследований ученых по проблемам конфликтности студенческой молодежи. Представлены собственные результаты психодиагностики способов реагирования в конфликтных ситуациях студентов-аграриев. Даны рекомендации по формированию конфлик-тологической компетентности обучающихся вуза.
Проблемы сопряжения образовательных и профессиональных стандартов
при подготовке физиков
Authors: Корнева Ирина Павловна , Корнев Константин Петрович
Published: December 2023

Рассматриваются актуальные проблемы интеграции образовательных и профессиональ-ных стандартов. Показано, что процесс сопряжения стандартов является сложным и дале-ким от завершения. Приведен пример сопряжения образовательного стандарта высшего образования по направлению подготовки 03.03.02 «Физика» (бакалавриат) и профессио-нального стандарта 01.001 «Педагог».
Инновационные технологии в системе преподавания огневой подготовки
в военных образовательных организациях войск национальной гвардии РФ
Authors: Жемчужников Александр Васильевич
Published: December 2023

Раскрываются возможности и перспективы применения инновационных технологий в реа-лизации основной профессиональной образовательной программы по дисциплине «Огне-вая подготовка». Демонстрируются опыт и педагогические результаты применения WEB-решений в рамках освоения образовательного курса. Выделен подавляющий ряд преиму-ществ применения инновационных технологий обучения огневой подготовке в сравнении с традиционными формами освоения вышеуказанной дисциплины. Раскрыты особенности применения программного обеспечения образовательного процесса в условиях импорто-замещения и перехода на отечественное программное обеспечение. Сделан акцент на применении программных средств в рамках организации самостоятельной работы курсан-тов военных образовательных организаций. Поднимается проблема необходимости орга-низации целенаправленной работы с обучающимися по формированию психологической готовности обучающихся к применению боевого ручного стрелкового оружия и средств ближнего боя в рамках освоения курса. Предложен инновационный способ повышения уровня психологической готовности с использованием инновационных средств дополнен-ной реальности при организации практических стрельб.
Изучение возможностей айтрекинга в педагогических исследованиях на примере оценки восприятия различных форм представления образовательных материалов
Authors: Сорочинский Максим Анатольевич , Никифоров Дмитрий Семенович
Published: December 2023

Айтрекинг, или отслеживание взгляда, является методом изучения человеческого восприятия и внимания путем записи движения глаз. В последние годы этот метод получил широкое применение в различных областях, включая педагогические исследования. Рассмат-ривается попытка использования технологии айтрекинг в качестве инструмента для оцен-ки восприятия различных форм представления образовательных материалов. Проведен пилотный эксперимент, в котором участники просматривали и прослушивали различные образовательные материалы, представленные в виде текста, звука и презентаций. С помощью айтрекинга были записаны данные о движении глаз, точки интереса участников в хо-де изучения материалов текста и презентации, которые затем были проанализированы. Такой подход к оценке образовательных материалов может быть полезным для их даль-нейшей оптимизации и улучшения. Использование технологии айтрекинга для оценки восприятия образовательных материалов имеет большой потенциал и может стать полезным инструментом для разработки и улучшения образовательных программ и материалов.
Актуальные вопросы кадрового обеспечения строительной отрасли
специалистами с высшим и средним профессиональным образованием
Authors: Любишина Светлана Александровна , Михайлов Александр Юрьевич
Published: December 2023

. Рассматриваются актуальные вопросы кадрового обеспечения строительной отрасли в Калининградской области специалистами с высшим и средним профессиональным обра-зованием. Проанализированы данные по количеству студентов, поступивших и окончив-ших учебные заведения в Калининградской области по направлению «Строительство». Выполнен анализ трудового стажа выпускников вузов за последние 20 лет, работающих ведущими специалистами, главными инженерами, руководителями проектов, руководите-лями структурных подразделений и строительных организаций. Выполнена обработка статистических данных, сформулированы выводы.
Педагогические условия формирования ценностно-смысловой
профессиональной я-концепции студентов педагогического университета
Authors: Новикова Ирина Сергеевна
Published: December 2023

Представлено описание педагогических условий формирования ценностно-смысловой профессиональной я-концепции студентов педагогического университета, их особенности и содержание; обзор имеющихся исследований в области понимания категорий «ценно-сти», «я-концепция» и результаты опроса студентов по данной теме.
Effect of ginger, Zingiber officinale extract on growth performance, digestive enzyme and stress tolerance of whiteleg shrimp, Litopenaeus vannamei juveniles
Authors: Tu Phan Thi Cam , Lien Nguyen Thi Kim , Diep Doan Xuan , Ly Tien Hai
Published: December 2023

This study evaluated the effects of ginger extract as a feed additive on the growth performance, digestive enzymes, and resistance to environmental stress of the whiteleg shrimp, Litopenaeus vannamei. 1200 juveniles were randomly allocated into four groups with three replicates. Shrimps were fed diets supplemented with 0 (T0-control), 0.5 (T1), 1 (T2), and 1.5 g kg-1 of ginger extract (T3) for 56 days. The results indicated that shrimp fed with ginger extract had a lower feed conversion ratio (FCR) than the control. In addition, shrimp fed with 0.5 g kg-1 of ginger extract had significantly greater weight gain and protease activity in the intestine than those in the control group. However, dietary supplementation with ginger extract did not significantly affect survival rates. After 56 days of culture, shrimp fed with 0.5 and 1 g kg-1 of ginger extract had higher survival rates than the controls after 72 – 96 h exposure to high ammonia stress (40 mg L-1). Based on the study’s findings, ginger extract could be recommended for shrimp feed to enhance growth and resistance against stress factors, and the optimal level is 0.5 g kg-1.
Nation Building and Religion
Authors: Turbucz Dávid
Published: December 2023

The leader cult built up around Miklós Horthy, the Regent of Hungary between 1920 and 1944, was one of the leader cults that appeared after World War I as a response to the critical social and political conditions. According to the main message of Horthy’s selectively constructed image, he was the only one who could achieve the national goals and restore the lost national glory. In my paper, I analyze religion, primarily Christianity, as a domain from which the cult-makers selected, (mis)used, and manipulated symbols, elements, and concepts, such as ‘resurrection’, ‘rebirth’, ‘salvation’, ‘the Passion of the Christ’, ‘selectness’, ‘the promised land’, and references to the will of divine providence for justifying the leadership of Horthy. Religious symbols also shaped and strengthened the national identity. It is shown that the traditional churches, because of the cooperation between them and the state, made a significant contribution to strengthening the leader’s legitimacy in this way. This is the reason why the term ‘politicized religion’, introduced by Juan J. Linz, seems appropriate in this context. Naturally, this was a wider phenomenon in Hungary, but the Horthy cult is its striking example.
Dark Humor in the Poetry of Sherman Alexie and Ahmed Matar: A Comparative Study
Authors: Jasim Al-Hemeedawi Mustafa Amjed , Adul Hadi Shahad Ammar
Published: December 2023

Dark humor is a form of comedy that explores taboo topics such as death, disease, and tragedy. While it is often controversial and can be offensive to some, it is also a means of coping with difficult or uncomfortable topics and offering a fresh perspective on societal norms. Just as stated by Merriam-Webster’s Encyclopedia of Literature, dark humor or black humor is a kind of humor that is marked by the use of morbid, ironic, or grotesquely comic episodes that ridicule human folly. However, this paper examines the concept of dark humor by tackling some of the significant poems of the English poet “Sherman Alexie” and the Iraqi poet “Ahmed Matar.” Those two poets discuss subjects and problems of real-life experiences. The purpose of this research is to shed light on Native Americans' daily lives on reservations and demonstrate their pain as well as the poet’s personal experience there, which is discussed by Sherman Alexie in his poems, “Futures”, “Traveling”, “Translated from the American”, “Giving Blood”, “War all the time”, “Reservation cap driver”, “The mice war”.  While the Iraqi poet tended to criticize Arab rules, the lack of freedom they force, their use of torture, the government, and their persuasion of authority at all costs. Here are some of his notable poems that this research are going to explain and make critique in details. “They put a watchdog on my mouth", "وَضَعوا فوقَ فمي كلبَ حِراسه",  “My awful silence”, "صمتي الرهيب", “The lost Caravan”, "قافلة تائهة". Ultimately, this paper aims to offer a fair viewpoint on the usage of dark humor and to stimulate additional investigation into its psychological and social significance. It can be hypothesized that Dark humor has been used heavenly by Ahmed Matar and Sherman Alexie in their poetry, and the researcher is going to show the importance of using humor is to attack the capitalist system, as  in Sherman Alexie country, and the ruthless hegemonic government as in Ahmed Matar' country. It is used to show vulgarity of governments and to amuse the audience to certain extent.
Penerapan Peraturan Daerah Kabupaten Maluku Tengah Nomor 11 Tahun 2022 Tentang Pengelolaan Sampah Di Wilayah Pesisir Kecamatan Kota Masohi Kabupaten Maluku Tengah
Authors: Samal Hikma Fajaria , Sedubun Victor Juzuf , Irham Muhammad
Published: December 2023

Environmental health in Indonesia is still a very diverse problem and from year to year it has not been resolved properly. Problems that occur include pollution problems, both water pollution, air pollution, and soil pollution. The writing method in this study uses an empirical juridical method with a statute approach. The data sources used are primary data sources in the form of interviews and observations and secondary data in the form of journals, books and data on the internet related to research. Data was collected through observation, interviews and documentation. The results of the study show that (1) waste management in the coastal area of ​​Kota Masohi District is not running according to regulations, as seen from the lack of attention from the government and the untouchability of infrastructure and services for waste management in the area. (2) the community's role was not carried out properly due to a lack of understanding of the regional regulation and the government did not carry out its role properly due to budget constraints. The implications of the research are (1) It is hoped that the government will be more active in disseminating the Central Maluku Regency Regional Regulation No. 11 of 2022 concerning Waste Management sees that many people do not know the contents of the regional regulation (2) It is hoped that the Environmental Service can carry out their duties and functions in implementing the regional regulation. (3) It is expected that the community will always play an active role in assisting the government in maintaining environmental cleanliness and health.
Kewenangan Pembimbing Kemasyarakatan dalam Melakukan Diversi Pra Ajudikasi (Studi pada Balai Pemasyarakatan Kelas II Ambon)
Authors: Nusaly Angelina Imanuela Debby , Pattipawae Dezonda Rosiana , Tuhumury Carolina
Published: December 2023

The criminalization of children who commit criminal offenses requires a community research report from the Correctional Center, which in this case is made by the Community Supervisor as regulated in the provisions of article 1 number 13 of Law No. 11 of 2012 concerning SPPA. One of the cases handled by the Community Supervisor is a case of persecution, based on police report Number B/113VII/1019/Reskrim. The client underwent an examination process at the Ambon Island and Lease Islands police station for allegedly committing the crime of persecution as referred to in Article 170 paragraph (1) of the Criminal Code (KUHP). The purpose of this research is to ask for consideration or advice from the Community Supervisor after the criminal offense is reported and the Community Supervisor is also not involved in the diversion process at the investigation stage. This Research uses normative legal research methods and will be studied based on positive legal provisions, as well as legal principles. and using primary, secondary and tertiary legal materials. This research uses normative legal research methods and will be studied based on positive legal provisions, as well as legal principles. and using primary, secondary and tertiary legal materials.The result and discussion shows that the authority to determine Diversion is given to law enforcement officials handling children's cases,Community Research from the Investigator as stipulated in Article 28 of Law No. 11 of 2012 concerning SPPA. After the Community Supervisor conducts the research, the results of the community research will be given to the Investigator. If the Investigators do not ask for consideration or advice from the Community Supervisor in the attempted diversion process, it can be said that the diversion process at the investigation stage is null and void.
Pergantian Antar Waktu Anggota Saniri Negeri Tanpa Usulan Soa Dan Badan Saniri Negeri
Authors: Rikumahu Valentino Victor Exel , Salmon Hendrik , Mustamu Julista
Published: December 2023

This research was motivated by Central Maluku Regency Regional Regulation Number 04 of 2006 concerning Guidelines for Structuring State Saniri or State Consultative Body. This regulation mandates that members of Saniri Negeri are representatives of genealogical elements of society, in this case Soa, so that Soa has the authority to send representatives as members of Saniri Negeri. This type of research is normative legal research, the problem approach in this research is the statutory approach, and the case conceptual approach, the sources of legal materials are primary legal materials and secondary legal materials, legal materials that have been collected and grouped using a statutory approach, then synchronized with the legal concepts and principles studied to be analyzed normatively to answer the legal issues studied based on the approach used in this research. The results of this research are that the Regent's decision to make interim changes to the members of Saniri Negeri without a proposal from Soa and Saniri Negeri is a decision that does not meet the requirements for the validity of a decision, namely authority, procedure and substance which results in the decision being invalid or can be cancelled.
Tanggung Jawab Badan Usaha Milik Negara Dalam Kegiatan Ekonomi Pada Cabang-Cabang Produksi Yang Tidak Menguasai Hajat Hidup Orang Banyak
Authors: Nabila Syadzwina Hindun
Published: December 2023

Analysuing the position of monopoly State-Owned Enterprises in the perspective of business competition law which could potentially give rise to barriers in business competition in particular concerning control over production branches are considered important and master his life much. Though it is excluded in law number 5 of 1999 concerning the prohibition of Monopolies and Anticompetitive Business practices are unhealthy, but that should not be considered a monopoly owned by the State-Owned Enterprises at the same time have the power over the market, and all the power over its own market not obliging him to carry on the practice of healthy competition. Existence of State-Owned Enterprises in the perspective of business competition law is the implementation of Article 33 of the Constitution of 1945, where the presence of the NRI Soes is a manifestation of the State's role in the national economy for the well-being of the people. The position of monopoly State-Owned Eterprises in the perspective of business competition law is still frequently abused the rights relating to the control of the State giving rise to unhealthy business competition. A monopoly held by State-Owned Enterprises should be stabilised so that serves as the market competition can run healthy. Criteria for State-Owned Enterprises can be given a monopoly in business competition law perspective, just look at the functions and Government intervention in the economy aimed at the earliest possible time the prosperity of the people. Criteria for State-Owned Enterprises can be given a monopoly should be seen from the form and objectives of the establishment of State-Owned Enterprises as well as the magnitude of the ownership of the Government's stake in it.
Tindak Pidana Korupsi dan Alokasi Dana Desa
Authors: Salmon Harly Clifford Jonas , Saimima Judy Marria
Published: December 2023

Introduction: The village funds that are managed are expected to realize the welfare of the village community. Community welfare can make a country strong and can compete with other countries. To be able to meet the needs of a quality life, it can be seen from how welfare is. Therefore, welfare is the main value that is always pursued so that humans can realize it. One important factor in realizing welfare is the existence of village funds. Efforts to increase awareness of village officials on the management of state finances, in this case the management of village funds for village officials, require counseling on the allocation of village funds and criminal acts of corruption. The low level of understanding and awareness of the law can be caused by the lack of socialization and supervision, this can be seen from the high level of corruption that occurs in Indonesia, especially in rural villages in Indonesia including Maluku, the lack of community access to knowledge of village financial management certainly causes miss management in village financial management.

Purposes of the Research: Analyzing Corruption in Village Fund Allocation.

Methods of the Research: The research method used is normative juridical, with a statutory approach and a conceptual approach. The sources of legal materials used are primary, secondary and tertiary legal materials.

Results of the Research: The management of village funds in Indonesia, including in the Maluku region, should aim to improve the welfare of village communities. However, unfortunately, there are several obstacles that hinder the achievement of this goal. Low levels of legal understanding and awareness among village officials and village financial management tools contribute to this problem. Therefore, to overcome this problem, serious efforts are needed to improve understanding and legal awareness related to village fund management. This includes counseling on the allocation of village funds and the impact of corruption crimes. Better education and training should be provided to village officials and staff involved in village financial management. Only in this way can we reduce the level of corruption that harms village communities and the country as a whole.
Efektivitas Kejaksaan Dalam Penanganan Perkara Tindak Pidana Korupsi di Maluku Sebagai Wilayah Kepulauan
Authors: Renfan Nur Hayati
Published: December 2023

Introduction: Based on the Prosecutor's Law number 16 of 2004, especially in Article 30 paragraph 1 letter d it states "in the criminal field the Prosecutor's Office has the duty and authority to conduct investigations into Certain Criminal Laws”. From this it is known that one particular case is a criminal act of corruption. Moreover, taking into account that Maluku is an archipelago, of course there are problems in implementation, which of course are experienced by every District Attorney's Office.

Purposes of the Research: This study aims to find out how the effectiveness of handling corruption cases in Maluku as an archipelago.

Methods of the Research: This paper uses empirical juridical research methods. The researchers used a case approach (case approach).

Results of the Research: The results of this study shows that the Prosecutor's Office in the Maluku region has not been effective in handling Corruption Crime Cases in the archipelago area because law enforcement and legal justice of the prosecutor's office in the Maluku region which are contained in regulations do not accommodate case handling in the archipelago area, this has an impact on non-compliance with the principle of speedy justice and low cost. Because the central trial for Corruption Crimes must be held in the provincial capital, so this is quite burdensome for each Prosecutor's Office. As for the obstacles to carrying out the effectiveness of legal handling, the authors found that there were six (6) factors, namely budget limitations, difficulty accessing from one island to another, internet network in the archipelago, no regulations governing the handling of corruption in the archipelago, difficulties confiscating goods, and the Corruption Court located in Ambon City.
Production, characterization and evaluation of the chemotherapeutic and immunogenic potential of protein based virus-like particles in tumoral and immune cell lines
Authors:   , Gonçalves Amanda Patrícia
Published: December 2023

In this thesis, nanotechnology was used to develop three inedited platforms with clinical applications. Results are presented in three chapters written in article format. In the first chapter, in vitro assays are used to characterize a new doxorubicin (DOX) carrier virus-like platform and to evaluate the cell effects of murine melanoma cells treated with free DOX or carried DOX. It is showed that carried DOX promotes higher cell death rates and enter cells in a different manner whether compared with free DOX. In the second chapter, the Spy Catcher/Spy Tag technology was used to conjugate different peptides to rod-shaped virus-like particles (VLPs). It is shown that two different types of antigen-presenting cells (APCs) can take up decorated VLPs and this promotes the activation of immune response by increasing CD80 and CD86 expression. In the third chapter, Spy Catcher/Spy Tag technology was also used to conjugate anti-EGFR nanobodies to the surface of DOX-loaded VLPs. It is shown that particles displaying anti-EGFR nanobodies promote a more accentuated decrease on cell viability of human colorectal cancer cells whether compared with non-decorated particles. In conclusion, this work present the full production and characterization of three distinct nanoplatforms and a solid in vitro evaluation of a range of cell mechanisms such as endocytosis, apoptosis and autophagy. The achieved results suggest that the constructions presented here have features that put them as nanoplatforms with potential clinical applications such as vaccine platforms and drug delivery systems. Keywords: Nanotechnology. Drug-delivery systems. Vaccine platforms. Protein-based particles. Nucleic acid-based particles. Particle decoration. Doxorubicin. Cancer.
Understanding Self-Driving Vehicles - Current State and Challenge
Authors:   NVIDIA, Babu Rajasekaran Suresh
Published: December 2023

The development and deployment of self-driving cars has the potential to revolutionize the transportation industry and improve the lives of people around the world. However, several challenges must be overcome before widespread deployment can occur. This paper provides an overview of the current state of self-driving cars and discusses the main technical, regulatory, and ethical challenges facing the industry. Additionally, the paper highlights the potential benefits of self-driving cars, such as improved safety, increased mobility, reduced traffic congestion, and lower transportation costs. The conclusion provides a summary of the challenges and prospects of self-driving cars and suggests directions for future research in this field.
Medullary and Foraminal Stenosis by Lumbar Vertebral Hemangioma: Case Report
Authors:   Hospital Beneficência Portuguesa de Ribeirão Preto Neurosurgery Department, Nery Breno , Fechine de Alencar Neto Joaquim ,   Hospital Beneficência Portuguesa de Ribeirão Preto Neurosurgery Department, Ferreira Marques Luis Felipe ,   Hospital Beneficência Portuguesa de Ribeirão Preto Neurosurgery Department
Published: December 2023

Vertebral hemangiomas can be defined as benign vascular bone tumors, accounting for only about 3% of spinal tumors. In general, they may demonstrate an asymptomatic clinical presentation, being found accidentally on imaging tests. They have an incidence of about 2.0-27% in the general population and do not require intervention in incidental cases.
Forgiving Road Design and Improvement of Accident Black Spots: A Case Study for Düzce City
Authors: SERİN Sercan , ÖNAL Yakup , KAYADELEN Cafer , MUTLU Muhammet Fatih
Published: December 2023

The aim of changing the causes and consequences of traffic accidents, preventing possible human deaths, and providing more comfortable navigational safety is a common situation especially in the highway sections of our country where traffic accidents occur frequently. In the study, the concept of the forgiving road, which was brought to the agenda of our country by the General Directorate of Highways (KGM) in 2013 and still has problems in implementation, was examined. Investigations have been made on the highway sections where the same type of accidents occur frequently, and it has been emphasized how these highway sections can be forgiving roads. A correct and planned road design or improvement will directly contribute to a dramatic reduction in accident rates. In this context, three different accident points that need improvement within KGM have been determined. Considering the forgiving road design features on a total of three highway sections, on-site investigations were made, and recommendations were made.
Socioeconomics and management of small cetacean bycatch in Ghana
Authors: Asiedu Berchie , Amponsah Samuel K. K. , Apraku Andrews , Ntim Lesley , Failler Pierre , Henneh Samuel , Amekor William , Ackah Rachael , Waerebeek Koen Van
Published: December 2023

Small cetacean bycatch in artisanal fisheries and deep‐sea fishing operations is a serious and persistent threat to conservation in coastal communities in Ghana. We assessed the bycatch and management of small cetaceans in four coastal communities by administering 73 questionnaires to fishers and recording their catches. Our findings show that dolphin feeding habits, gear attributes and habitat use of targeted finfish species were the main factors driving bycatch of small cetaceans in Ghana. Gear damage and reduced catches were among the effects of bycatch reported by fishers. In addition to direct consumption of small cetacean meat, fishers use them as bait in shark‐fishing activities. Our results suggest the livelihood of over 70% of fishers will be threatened if management measures are implemented. Fishers were unaware of the Wildlife Division that manages small cetaceans in Ghana. We recommended that a co‐management approach between the government and locals should be adopted when developing and implementing measures for the conservation of small cetaceans. A community awareness programme should be carried out to raise awareness about threats facing these species and the importance of conservation.
METHODOLOGY FOR ASSESSING THE MARKET VALUE OF VENTURE CAPITAL COMPANIES
Authors: Виноградов А.Ю.
Published: December 2023

Статья посвящена анализу подходов и методов оценки венчурных компаний (стартапов) в зарубежной и отечественной оценочной практике на различных стадиях жизненного цикла компаний. Основными сложностями при оценке рыночной стоимости стартапов являются отсутствие финансовых показателей (выручка, EBITDA), к которым могли бы применяться классические мультипликаторы в рамках сравнительного подхода, а также проблематичность обоснованного и достоверного прогнозирования денежных потоков компании в условиях высокой неопределенности. В связи с этим в оценочной практике было разработано множество методов оценки, представляющих собой определенные модификации традиционных подходов к оценке, используемых для определения рыночной стоимости зрелых компаний. Автором проведена аналитическая работа по исследованию различных методов оценки с выявлением их слабых и сильных сторон, а также анализ их применимости на различных стадиях жизненного цикла венчурных компаний. Сделан вывод, что на текущий момент в научной литературе и оценочной практике не существует идеального и универсального метода оценки стоимости венчурной компании. По мере развития венчурной компании методы оценки меняются с качественных в сторону более традиционных количественных методов.

The article analyses the approaches and methods of valuation of venture capital companies (start-ups) in foreign and domestic valuation practice at different stages of the life cycle of companies. The main difficulties in assessing the market value of startups are the lack of financial indicators (revenues, EBITDA) to which classical multipliers could be applied in a comparative approach, as well as the problem of reasonable and reliable prediction of company cash flows in high uncertainty. In this regard, the valuation practice has developed many valuation methods which are certain modifications of traditional valuation approaches used to determine the market value of mature companies. Analytical work was carried out to investigate various valuation methods, identifying their weaknesses and strengths, as well as an analysis of their applicability at different stages of the life cycle of venture capital companies. The main conclusion is that there is currently no ideal and universal method for valuing a venture capital company in the scientific literature and valuation practice. As the venture capital company develops, valuation methods shift from qualitative to more traditional quantitative methods.
Smart Water Quality Monitoring System In Progo River, Magelang Regency, Central Java
Authors: Waluyo Waluyo , Sari Annisa Novita , Tri Aji Muhammad
Published: December 2023

Traditionally, air quality detection is done manually by means of air samples obtained locally and sent for analysis to a laboratory, which takes a long time, is expensive, and requires human resources. This technique does not provide real-time data. Therefore, there is a need for innovation and new technology that makes it easier to monitor and analyze air quality data in real-time with a microcontroller approach and certain water quality sensor parameters, where the recorded data will be recorded and sent via wireless with the Internet of Things (IoT) approach. Parameter values such as temperature, humidity, water level, turbidity, and pH in general can be properly recorded by each sensor. The goal of this research is to create measuring equipment for aquatic characteristics such as pH, water turbidity, water level, ambient air temperature, and humidity using the Thingspeak website and telegram. System design, programming the ATmega2560-based Arduino Mega microcontroller and ESP8266-based NodeMCU using the Arduino IDE, and constructing and testing equipment on a prototype scale and directly in the field are the methods employed in this research. According to the results of field testing, the water temperature sensor is capable of capturing fluctuating values ranging from 32.4 to 34.1 oC. Meanwhile, the air humidity sensor measured 33.5-35.6% humidity. The ultrasonic sensor records the height of the river water level pretty well, with a value of 28-71 cm. A pH sensor measures the pH of the water and records data in the form of water voltage ranging from 3.34 to 5.38 volts. Based on IoT, the sensor recording results are subsequently sent online and received via the Telegram application.
Pengaruh Brand Trust, Brand Awareness Terhadap Purchase Intention Melalui Brand Satisfaction Sebagai Variabel Intervening
Authors: Fitriani Tasbicha Nur , Kurniawan Bayu , Goeltom Henry C
Published: December 2023

Penelitian ini bertujuan untuk mengevaluasi pengaruh kepercayaan merek dan kesadaran merek terhadap kecenderungan konsumen melakukan pembelian dengan menggunakan kepuasan merek sebagai variabel intervening. Konsumen yang pernah menggunakan atau membeli produk Skincare K-Beauty di Kabupaten Bekasi merupakan populasi yang digunakan untuk penelitian ini. Informasi primer dikumpulkan dengan cara pembagian Google form kepada konsumen yang pernah menggunakan atau membeli produk Skincare K-Beauty di wilayah Kabupaten Bekasi. Purposive sampling dengan pengukuran skala likert merupakan metode pilihan untuk mengumpulkan sampel. Pengolahan data mengunakan program PLS-SEM versi 3. Temuan Penelitian ini menunjukkan bahwa kepercayaan vendor mempengaruhi kepuasan vendor, kepercayaan vendor mempengaruhi kepuasan vendor, kepuasan vendor mempengaruhi niat pembelian vendor, kepercayaan vendor tidak mempengaruhi kepercayaan vendor, dan kepercayaan vendor mempengaruhi kepuasan vendor
Accounting Theory Formulation: the Methodological Approach
Authors: OLADUTIRE Oladeji E. , SOYINKA Kazeem A. , AKINNOLA Mofehintolu T.
Published: December 2023

This study delves into the formulation of accounting theory and the various methodological approaches used in this endeavor. It explores the significance of accounting theory in the context of financial reporting, decision-making, and the development of accounting standards. The development of accounting theory from a methodological perspective is a difficult and pervasive subject that affects how financial statements are prepared and presented. The research methodology employed in this study includes a comprehensive literature review, content analysis, and empirical investigation. The findings contribute to a deeper understanding of the evolving nature of accounting theory formulation and its implications for the accounting profession. The study concludes that the positive and normative accounting theory is the first set of accounting theories that produce other accounting theories.
Editorial
Authors: Piedimonte Fabián C.
Published: December 2023

Bienvenidos a una nueva edición de NeuroTarget. En esta oportunidad, como ha sucedido cada dos años en los últimos tiempos, este número de NeuroTarget se encuentra completamente dedicado a la producción científica generada durante la celebración de la Reunión ABCUR IX, los días 5, 6 y 7 de diciembre, en la ciudad de Mendoza, Argentina.
Adicionalmente, contamos con el trabajo original, in extenso, “Abordaje seguro al núcleo subtalámico. Impacto del ángulo parasagital mayor de 20 grados”, elaborado por el grupo de trabajo del cual participa el Dr. Nelson Quintanal, neurocirujano referente del Centro Internacional de Restauración Neurológica (CIREN), emplazado en la ciudad de La Habana, Cuba. La lectura de su trabajo despertó remembranzas de mis acercamientos iniciales al fascinante mundo de la neurocirugía funcional.
Dünya Ve Türkiye’de Şirketleşme: 2015-2021 Yılları Arası Karşılaştırmalı Analiz
Authors: ALİUSTA Hakan
Published: December 2023

Kurumsallaşmanın önemli bir adımı olan şirketleşme, faaliyet alanını genişletmek, vergisel avantajlardan yararlanmak, daha fazla fon kaynağı sağlayabilmek ve uluslararası markalaşmak gibi sebeplerden dolayı işletmeler için daha fazla önemli hale gelmektedir. Bu çalışmanın amacı 2015-2021 yılları arası istatistiki verilerden yararlanarak dünya ve Türkiye’deki şirketleşmeye ilişkin değişimi karşılaştırmalı analiz yöntemi kullanarak incelemektir. Veriler OECD Statistics, Eurostat, Statista, Türkiye İstatistik Kurumu (TÜİK), Türkiye Odalar ve Borsalar Birliği (TOBB) ve diğer kuruluşlardan elde edilmiştir. Dünyada şirketleşme ve şirket sayıları 2020 yılı hariç son yirmi yılda artarak devam etmektedir. KOBİ’lerde en hızlı yükseliş Polonya, büyük şirketlerde ise İsveç ’te meydana gelmiştir. Türkiye’de şirket sayısında son yedi yıldır kesintisiz bir artış vardır. Büyüklerine göre en fazla artış mikro ölçekli şirketlerde, türüne göre ise Anonim Şirketlerde gerçekleşmiştir. Kurulan şirket oranları ortalamasında Portekiz, kapanan şirket oranları ortalamasında ise Bulgaristan ilk sırada yer alırken Türkiye listedeki 30 ülke arasında kuruluşta 5. sırada, kapanmada ise 4. sıradadır. 1. ve 2. yılında şirket sağkalım oranlarında İsveç birinci sırada yer almaktadır. Türkiye listedeki 25 ülke arasında sırasıyla 14.ve 18. sıradadır. Türkiye’de en çok şirket sırasıyla toptan ve perakende ticaret, imalat ve inşaat faaliyetlerinde yer almaktadır. Türkiye’nin ciro ile ölçülen ve %10’dan fazla büyüme gösteren şirket sayısı azalma eğilimindedir. AB’de Türkiye’deki şirket tarafından kontrol edilen şirket sayısı artmaktadır. Türkiye’de en çok kurulan ve kapanan şirket türü sırasıyla limited ve anonim şirkettir. Kurulan yabancı sermayeli şirketlerde yabancı sermaye oranının genelde azalma eğiliminde olduğu belirlenmiştir.