bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Aging Face Cream Preparations Made from Collagen Membrane Chicken Eggshell (Gallus gallus domesticus) Combined with Bee Honey (Apis mellifera)
Authors: Adinda Fitri Salsabila  , Erma Nur Janahwati  , Nata Dwi Anisa Nizma  , Shofia Amalia  , Muhammad Prasetya Kurniawan
Published: March 2022

Handling waste such as chicken egg shells requires innovation to be able to provide added value as a sustainable product. This study aims to extract collagen from chicken egg shell membranes combined with bee honey as an anti-aging face cream. This material has a very high model accuracy value (97.89%) which has the potential to inhibit aging due to Matrix metalloproteinase-1 (MMP-1). This research was carried out by extracting eggshell membrane collagen, making cream combined with bee honey, analyzing product properties, and interpreting virtual data. The results show that in 100 g of face cream formulation with active ingredients of chicken eggshell membrane collagen extract 4.1206% and bee honey 5.0251%; 77.0926% water; 0.0062% ash; 1,8690% protein; 0.0058% fat, the viscosity value was 65.94 dPas, and the pH was 7.08. Thus, this product did not irritate the skin of the experimental animals. The average value of attribute assessment (such as aroma, consistency, texture, stickiness, homogeneous sensation, color, appearance, itching, erythema, washing power, response after washing) was well received by the panelists with a score of 1-3,9 and the highest total achievement bacteria 25 CFU/g and yeast-mold 16 CFU/g met the skin moisturizer quality requirement (SNI 16-4399-1996) which should not exceed 102 CFU/g.

Key words: collagen; Matrix metalloproteinase-1; honey; extraction; organoleptic
Running as a Middle - Class Sport: A Case Study of Mari Lari Film in Indonesian Movies
Authors: Budiasa Meistra
Published: March 2022

Sport is portrayed as an entertaining activity that various people from different social class like. Any information from sports can be seen through media. Therefore, sports and media are correlated because in general the role of the media is to attract public attention. Other than that, sports have various concepts that can be interpreted symbolically, one of which is by social groups through the mediazitaion. This research uses Critical Discourse Analysis (CDA) to examine how Mari Lari can represent the sosial class lifestyle. The results show how the middle class is represented through visual cues such as clothing styles, and choice of sports. In addition, this research is expected to be a reference for further researchers who want to review films about sports.
Forms of Linguistic Deviations Found in Latah Coprolalia Behavior in Jombang, East Java, Indonesia
Authors: Pamungkas Sri
Published: March 2022

Latah is a psychogenic language disorder in Malay and Indonesian society stemming from cultural pressure, mimicry, and the like. It is expressed as a verbal or nonverbal response to surprise or shock. The focus of this research was the form of linguistic deviation in individuals in Jombang, East Java, with latah coprolalia behavior, specifically latah behavior by expressing lingual forms that refer to the male or female genitalia. Data collection comprised observations and interviews, while data analysis used Spardley’s ethnographic approach with four advanced paths: (1) domain analysis, (2) taxonomy analysis, (3) componential analysis, and (4) culture values analysis. The findings showed that latah coprolalia behavior occurs in men with both low and high education levels, and women with low education levels, but is not found in women with high education levels. Patting and verbal stimuli give rise to syntagmatic errors in the form of single words and sentences in men with high education, while in men with low education, syntagmatic errors happen in single sentences and multiple sentences. Meanwhile, women with low educational backgrounds displaying latah coprolalia behavior were identified as committing syntagmatic errors in the form of single words and sentences.
IZAZOVI SOCIJALNE INKLUZIJE DECE SA SMETNJAMA U RAZVOJU
Authors: Kovačević Ankica Simona
Published: March 2022

Zasnovana na humanoj ideji, inkluzija predstavlja aktivnosti individue i društva zarad aktivnog uključivanja marginalizovanih/ vulnerabilnih grupa u život zajednice na svim nivoima. Inkluzija, kao proces trajnih promena, polazi od pretpostavke promovisanja, zagovaranja i obezbeđivanja jednakosti u svetu koji se menja. Cilj ovog rada jeste da primenom analize sadržaja relevantne literature, kao i kvalitativnim terenskim istraživanjem (metodom polustrukturisanog intervjua) prikaže sa kojim se izazovima deca sa smetnjama u razvoju susreću u svakodnevnom životu. U radu se elaborira prihvaćenost deteta unutar vršnjačke grupe sa posebnim osvrtom na segmente: socijalne prihvaćenosti, podrške, uključenosti, napredovanja i samostalnosti. Rezultati istraživanja pokazuju da su izazovi i teškoće sa kojima se deca sa smetnjama u razvoju susreću u praksi indirektno povezani sa sistemskom podrškom koja im se pruža od strane institucija. Ukoliko i postoje barijere u interakciji sa društvenim okruženjem one su uslovljene nedostatkom inkluzivne kulture, nedovoljno razvijenim ili nedostupnim uslugama za podršku dodatnim potrebama deteta i neinformisanošću šireg okruženja kao glavnim kočnicama u razvoju inkluzivne prakse.
Descubrimientos sociolingüísticos homoeróticos en Facebook: revisión documental
Authors: Arias González Diego Ishaan Alejandro , Bohórquez Aunta Camila Andrea
Published: March 2022

El artículo muestra el análisis de una revisión documental, desde una perspectiva sociológica del lenguaje, sobre la interrelación entre las categorías: identidades sexuales, homoerotismo, narrativa identitaria, narrativa homoerótica e identidades virtuales. Asimismo, se exponen los avances teóricos y científicos que permiten el desarrollo analítico en dos fases, heurística y hermenéutica, y su abordaje en la ciencia desde diferentes disciplinas, que confluyen en la orientación del valor del discurso y las relaciones sociosemánticas que intervienen en un proceso de autopoiesis digital. Las conclusiones evidencian las premisas que guiarán el desarrollo del trabajo de campo, de manera que los investigadores partan del compendio monográfico para vislumbrar la conceptualización del tema ante los nuevos fenómenos de la realidad.
A Smart Stick for Assisting Blind Peoples
Authors: Kamal Priyansh , Chaurasiya Sudhir kumar , Saini Yash , Yadav Manoj Kumar
Published: March 2022

Abstract: In this paper, we introduce a smart stick system for assisting blind people. The smart stick comes as a proposed solution to enable visually impaired people to find difficulties in detecting obstacles and dangers in front of them during walking and to identify the world around. The system is designed to act like an artificial vision and alarm unit. The system consists of three sensors: ultrasonic sensor, water sensor, and heat flame sensor, microcontroller (Arduino Uno R3) to receive the sensor signals and process them into short pulses to the Arduino pins where buzzers and led bulb are connected. We seek in our project to provide a smart stick affordable and suitable for most blind people, and also it is light in weight. It can be made available to all segments of the society and their families who need them. Keywords: SMART STICK, BLIND PEOPLE, ARDUINO UNO, ULTRA SONIC SENSORS, HEAT FLAME SENSOR.
Deterministic transformations between unitary operations: Exponential advantage with adaptive quantum circuits and the power of indefinite causality
Authors: Quintino Marco Túlio , Ebler Daniel
Published: March 2022

This work analyses the performance of quantum circuits and general processes to transformkuses of an arbitrary unitary operationUinto another unitary operationf(U). When the desired functionfa homomorphism, i.e.,f(UV)=f(U)f(V), it is known that optimal average fidelity is attainable by parallel circuits and indefinite causality does not provide any advantage. Here we show that the situation changes dramatically when considering anti-homomorphisms, i.e.,f(UV)=f(V)f(U). In particular, we prove that whenfis an anti-homomorphism, sequential circuits could exponentially outperform parallel ones and processes with indefinite causal order could outperform sequential ones. We presented explicit constructions on how to obtain such advantages for the unitary inversion taskf(U)=U−1and the unitary transposition taskf(U)=UT. We also stablish a one-to-one connection between the problem of unitary estimation and parallel unitary transposition, allowing one to easily translate results from one field to the other. Finally, we apply our results to several concrete problem instances and present a method based on computer-assisted proofs to show optimality.
Competitive advantages of going public: Evidence from incumbent firms in the USA
Authors: Han Snow
Published: March 2022

Industry incumbent firms (existing public peer firms) experience significant negative stock returns around large initial public offerings (IPO) events in the same industry (Hsu, Reed, & Rocholl, 2010), implying a competitive advantage shift resulting from IPO events. We investigate whether such large IPO events generate real impact in the long run and increase the risk and thus cost of equity of incumbent firms. Using data from 1998–2019, we found that within three years after large IPO events, industry incumbents exhibit positive abnormal returns even after controlling for known asset pricing factors. In addition, their default probability also increases. Using intertemporal capital asset pricing model (ICAPM), we show that incumbent firms’ stock returns become more sensitive to economic conditions, in other words, riskier. Following Hou and Robinson (2006), we propose that the increased risk to incumbent firms comes from industry competition. We provide empirical evidence that this is the case. Specifically, firms in industries with low product differentiability, a large number of public firms, and smaller market size have larger increases in expected returns. As robustness tests, we document that industry incumbents exhibit declines in unexpected earnings, which contradicts the notion that the observed positive returns can be attributed to persistent positive cash flow for industry incumbent
Extrapolation methods for solving hypersingular integral equation of first kind
Authors: Li Jin
Published: March 2022

The hypersingular integral equation has been studied widely in boundary
element methods, especially in natural boundary element methods. The
asymptotic expansion of error function of composite rectangle rule for
the computation of Hadamard finite-part integrals with the hypersingular
kernel $ 1/\sin^{2}(x-s)$ is obtained.
Extrapolation algorithm is constructed. In order to solve the
hypersingular integral equation, the superconvergence point is taken as
the collocation point, then the extrapolation algorithm is presented and
the convergence rate of extrapolation algorithm for hypersingular
integral equation is presented. At last, some numerical results are also
illustrated to confirm the theoretical results and show the efficiency
of the algorithms.
Evaluation of left atrial function using four-dimensional volume-strain in end-stage renal disease patients with preserved left ventricular ejection fraction
Authors: You Chunyuan , Li Lei , Zhang Pingyang
Published: March 2022

Objective: The purpose of this study was to investigate
alterations in routine echocardiographic parameters and left atrial(LA)
strains in normal LA and large LA groups in end-stage renal
disease(ESRD) patients. Methods: Thirty-five age-matched
healthy individuals and 82 patients with ESRD, including 52 with LA
maximum volume index(LAVmax I)＜34 ml/m2 (normal LA group)and 30 with
LAVmax I≥34 ml/m2 (large LA group), were enrolled. LA volumes and
longitudinal and circumferential strains were measured using
4-dimensional(D) volume-strain technology. Results: Left
ventricular(LV) wall thickness, the Left ventricular mass index(LVMI),
peak early diastolic trans-mitral flow velocity/average peak early
diastolic mitral annular velocity(E/ E’), and peak systolic
dispersion(PSD) were higher in normal LA and large LA group compared
with the control group. Mitral valve early diastolic velocity/mitral
valve late diastolic velocity(E/A), the early diastolic velocity at the
septal mitral annulus(E’ septal), the early diastolic velocity at the
lateral mitral annulus (E’ lateral), global longitudinal strain(GLS),
left atrial peak longitudinal strain of reservoir function (LASr) and
left atrial peak longitudinal strain of conduit function(LAScd) were
lower in normal LA and large LA group compared with the control group.
Left atrial peak circumferential strain of reservoir function(LASr-c)
and left atrial peak circumferential strain of contractile
function(LASct-c) were lower in the large LA group compared with the
control group. In ESRD patients, LASr-c and LASct-c showed a good
correlation with LAVmax I. Conclusions: This study showed that
LA longitudinal strains had decreased before LA enlargement. When LA
enlargement occurred, the circumferential strains decreased. This may
indicate that longitudinal strain changed earlier than circumferential
strain in ESRD patients.
Climate Change, Fossil Energy Mining Lead to the Floor Heating Effect
Authors: Mu Yao , Mu Xinzhi
Published: March 2022

In this paper, it is discussed that the oil-gas wells of mining
construction penetrates the geothermal reservoirs system cap rocks and a
lot of geothermal energy lost lead to the floor heating effect in fossil
energy mining processes, and its importance to global climate change. It
is also illustrated that the interrelationship among fossil energy
mining, deep geotemperature rise and abyssal ocean warming. Thus it
expresses the significance of energy mining affecting environmental
ecosystem and climate change in globe.
Mapping the links and gaps in life-history studies
Authors: Richardson Emily , Marshall Dustin
Published: March 2022

Understanding the ecological and evolutionary links between stages in
complex life histories is an important goal of biology, but studies
differ greatly in their approach. Some studies follow individuals across
their life history (“individual longitudinal”), while others follow
cohorts (“cohort longitudinal”)—each have their strengths and
weaknesses. Our understanding of links among life-history stages
probably depends on the approaches we use, but we have no estimates of
their relative prevalence. Using marine invertebrates as a model, we
used a formal, systematic literature map to screen 17,000+ papers
studying complex life histories. For 3,315 experiments from 1,716
articles, we characterised the study type, (i.e. cohort longitudinal,
individual longitudinal or single stage) as well as other factors.
Individual longitudinal studies are extremely rare, accounting for just
1.7% of studies. Clearly much progress has been made, but to fully
understand the links among life-history stages, more individual
longitudinal studies are necessary.
Spatiotemporal Measurement of Concentration-Dependent Diffusion Coefficient
Authors: Ahmadzadegan Adib , Zhang Jiacheng , Ardekani Arezoo , Vlachos Pavlos P
Published: March 2022

We introduce a new method to measure the concentration-dependent
diffusion coefficient from a sequence of images of molecules diffusion
from a source towards a sink. Generally, approaches measuring the
diffusion coefficient, such as Fluorescence Recovery After
Photobleaching (FRAP), assume that the diffusion coefficient is
constant. Hence, these methods cannot capture the concentration
dependence of the diffusion coefficient if present. Other approaches
measure the concentration-dependent diffusion coefficient from an
instantaneous concentration profile and lose the temporal information.
These methods make unrealistic assumptions and lead to 100% error. We
introduce a novel image analysis framework that utilizes spatial and
temporal information in a sequence of concentration images and
numerically solves the general form of Fick’s law using Radial Basis
Functions (RBF) to measure the concentration-dependent diffusion
coefficient. We term this approach as Concentration Image Diffusimetry
(CID). Our method makes no assumptions about the sink and source size.
CID is superior to existing methods in estimating spatiotemporal changes
and concentration-dependent diffusion. CID also provides a statistical
uncertainty quantification on the measurements using bootstrapping,
improving the reliability of the diffusion measurement. We assessed
CID’s performance using synthetically generated images. Our analysis
suggests that CID measures the diffusion coefficient with less than 2%
error for most cases. We validated CID with FRAP experimental images and
showed that CID agrees with established FRAP algorithms for constant
diffusion coefficient. Finally, we demonstrate the application of CID to
experimental datasets of a concentration gradient-driven protein
diffusion into a tissue replicate.
Transmigration of Copper IUCD leading to Abdominal Abscess: A Case Report
Authors: Lamichhane Ramesh , Kumari Swati , Khadka Anuska
Published: March 2022

Far migrated IUCD is an uncommon condition that has different
manifestations depending upon its location. We present the case of a
22-year-old primipara who had a spontaneous abortion after IUCD
placement and suffered chronic right lower abdominal pain thereafter.
Diagnostic laparoscopy revealed Cu-IUCD in the right iliac fossa.
MHD Stagnation Point Flow of Ternary Hybrid Nanofluid Flow over a Stretching/Shrinking Cylinder with Suction and Ohmic Heating
Authors: Khan Umar , Mahmood Zafar
Published: March 2022

There is a new type of nanofluid called ternary hybrid nanofluid that
can be used to improve heat flow. This study investigates effects of
magnetic field, mass suction with ohmic heating towards stagnation
region of stretching/shrinking cylinder of polymer based ternary hybrid
nanofluid flows in two dimensions with different shapes aspect. Under
the imposed assumptions, equations governing the flow will be modelled.
It is feasible to convert nonlinear partial differential equations that
are not exactly solvable via similarity transformation to a system of
ordinary differential equations, which are solved numerically. The
combination of Runge–Kutta-IV and shooting method in Mathematica has
been shown to have a substantial impact on the prevalence of heat
exchange and the mobility parameters of ternary hybrid nanofluids. The
number of nanoparticles with suction enhances heat transfer and skin
friction coefficient. Graphs and tables demonstrated the influence of
many factors such as suction, Reynold number, nanoparticles volume
fraction, magnetic field, Eckert number, stretching/shrinking on
temperature, velocity, skin friction and local heat transfer rate
coefficients curves. To verify the findings, a contrast study was
undertaken between the current research and previously published results
for a specific instance, and excellent agreement was discovered.
Effects of kefir consumption on cardiometadebolic risk factors: A systematic review and meta-analysis of randomized controlled trials
Authors: Yahyapoor Farveh , Haghighat Neda , Sohrabi Zahra , Asbaghi Omid , Bagherniya Mohammad , Atkin Stephen , Sahebkar Amirhossein
Published: March 2022

Background. Fermentation of lactose in milk by bacteria and yeasts
naturally present in kefir grains produces a beverage that has been
suggested to have cardiovascular benefit. This systematic review and
meta-analysis of randomized controlled trials (RCTs) aimed to evaluate
the effects of this kefir beverage on cardiometabolic risk factors.
Methods. Literature search utilised PubMed, Scopus, ISI Web of Science,
and Google Scholar for the articles published from inception until June
2021. Cardiometabolic risk indices extracted included insulin and
insulin resistance (HOMA_IR), total cholesterol (TC), triglyceride
(TG), high-density lipoprotein cholesterol (HDL-C), low-density
lipoprotein cholesterol (LDL-C), fasting blood sugar (FBS), haemoglobin
A1c (HbA1c) and body weight (BW). In total, six RCTs (314 subjects) were
selected for the meta-analysis. Inverse-variance weighted mean
difference (WMD) with a 95% confidence interval (CI) was calculated for
the mean changes in TC, TG, HDL-C, LDL-C, FBS, HbA1c and BW compared to
baseline. A random effects model was used to estimate the pooled WMD.
Results. Kefir intake significantly reduced fasting insulin (WMD:-3.69
micro-IU/mL,95% CI:-6.30 to -1.07,p=0.006,I2=0.0%) and HOMA-IR
(WMD:-2.56,95%CI:-3.82 to-1.30, p<0.001,I2=19.4%). No effect
on TC (WMD:-9.30mg/dL,95%CI:-20.00 to 1.39,p=0.088), TG (WMD:-1.35
mg/dL,95%CI:-13.28 to 10.58,p=0.824), HDL-c (WMD:0.70mg/dL,
95%CI:-1.30 to 2.71,p=0.491), LDL-C (WMD:-0.71mg/dL, 95%CI:-13.16 to
11.72, p=0.910), FBS (WMD: -2.73 mg/dL, 95%CI: -7.56 to 2.09,p=0.267),
HbA1c (WMD:-0.58 %, 95%CI: -1.79 to 0.61,p=0.339) or body weight
(WMD:-0.78 kg, 95%CI: -2.75 to 1.19,p=0.439) were found for kefir
treatment. Conclusion. Kefir has a beneficial effect on decreasing
insulin resistance; however, no effect was seen on BW, FBS, HbA1C or the
lipid profile.
Dispersal limitation contributes to host specificity of the mammalian gut microbiota
Authors: Mazel Florent , Guisan Antoine , Parfrey Laura
Published: March 2022

Different mammalian species host distinct gut microbes but the processes
shaping this specificity are not well understood. One model proposes
that barriers to microbial transmission promote specificity by limiting
dispersal between hosts and predicts that specificity levels measured
across individual hosts and microbes is correlated to individual
dispersal traits. Here, we leverage a large gut microbiota dataset (1490
samples from 195 host species) to test this prediction. We found that
specificity varies widely across bacteria (i.e. there are generalist and
specialist bacteria) and depends on their dispersal ability: bacteria
equipped with traits that facilitate transmission between host were
found to be less specific (more generalist) than microbes without those
traits. In addition, host specificity is dependent on the geographical
distance between sampled host individuals, which could result from
reduced transmission between hosts. Altogether, our findings suggest
that limited microbial dispersal abilities can foster host specificity.
Existence of nontrivial solutions for Schrödinger–Kirchhoff equations with indefinite potentials
Authors: Jiang Shuai , Yin Lifeng
Published: March 2022

We consider a class of Schrödinger–Kirchhoff equations in
$\mathbb{R}^{3} $ with a general nonlinearity
$g$ and coercive sign-changing potential $V$ so that the Schrödinger
operator -aΔ+V is indefinite. The nonlinearity considered here satisfies
the Ambrosetti-Rabinowitz type condition g(t)t≥μG(t)>0 with
μ>3. By Morse theory, we obtain the existence of nontrivial
solutions for this problem.
Analysis of two-operator boundary-domain integral equations for variable-coefficient Dirichlet and Neumann boundary value problems in 2D with general right-hand side
Authors: Ayele Tsegaye , Yimer Markos
Published: March 2022

The Dirichlet and Neumann boundary value problems (BVPs) for the linear
second-order scalar elliptic differential equation with variable
coefficients in a bounded two-dimensional domain are considered. The PDE
right-hand side belongs to $H^{-1}(\Omega)$ or
$\widetilde{H}^{-1}(\Omega),$
when neither classical nor canonical conormal derivatives of solutions
are well defined. Using the two-operator approach and appropriate
parametrix (Levi function) each problem is reduced to two different
systems of two-operator boundary-domain integral equations (BDIEs).
Although the theory of BDIEs in 3D is well developed, the BDIEs in 2D
need a special consideration due to their different equivalence
properties. As a result, we need to set conditions on the domain or on
the associated Sobolev spaces to ensure the invertibility of
corresponding parametrix-based integral layer potentials and hence the
unique solvability of BDIEs. The equivalence of the two-operator BDIE
systems to the original problems, BDIE system solubility, solution
uniquness/nonuniquness and invertibility BDIE system are analyzed in the
appropriate Sobolev (Bessel potential) spaces. It is shown that the BDIE
operators for the Neumann BVP are not invertible, and appropriate
finite-dimensional perturbations are constructed leading to
invertibility of the perturbed operators.
A Novel Preparation and Vapour Phase Modification of 2D-open Channel Bio-adsorbent Via ATRP for Uranium Separation
Authors: Ahmad Mudasir , Ren Jianquan , Xiu Tao , Naik Mehraj-ud-din , Zhang Qiuyu , Zhang Baoliang
Published: March 2022

An economical and highly uranium extraction from seawater remains a
crucial task for energy sources and environmental safety. Aiming for
improving mass transfer rate of uranium adsorption from seawater, a new
synthetic strategy was adopted for the fabrication of 2D-open channel
microporous bio-adsorbent for uranium extraction from seawater. Herein,
the in-situ ATRP grafting approach was adopted to graft divinylbenzene,
polyacrylonitrile onto the surfaces of microporous frameworks via the
vapour phase method. The post-synthetic functionalization was carried
out by hydrothermal method, where amidoxime groups are
structure-directing agents to trap uranium. Further, amidoxime groups
not only enhanced hydrophilicity but also adjusts adsorbents pKa. AO-Fc
faces minimum interference of competing ions and achieves a high uranium
adsorption capacity of 8.57±0.02 and 409±1 mg/g in seawater and
simulated solution. Despite its stable structure, AO-Fc exhibits a long
life span and negligible weight loss revealed AO-Fc could be applied as
a potential adsorbent for radionuclide.
Datura poisoning in a family: case series and literature review
Authors: rad Niloofar Khoshnam , Heydari Marziyeh , Mohammadi Keyhan , Mashayekhi Mojgan , Sahraei zahra , Gholami Kheirollah
Published: March 2022

Datura spp. is a potentially poisonous plant that is widely spread and
simply accessible, which can yield to poisoning with a central and
peripheral anticholinergic effect. We reported cases of family poisoning
caused by the herbal tea with refreshing effects that were identified as
Datura spp.
The burden of sleep disordered breathing in infants with Down syndrome referred to tertiary sleep center
Authors: Cho Yeilim , Kwon Younghoon , Ruth Chris , Cheng Samuel , Delrosso Lourdes
Published: March 2022

Introduction Children with Down Syndrome (DS) are at high risk of sleep
disordered breathing (SDB). We aimed to examine the burden of SDB in
infants with DS referred to tertiary sleep center. Methods Infants (≤12
months old) with DS who underwent consecutive polysomnography (PSG) at a
single academic sleep center over a 6-year period were included. OSA
(obstructive apnea hypopnea index [oAHI]>1/hr), central
sleep apnea (central apnea index>5/hr) and the presence of
hypoventilation (% time spent with CO2 > 50 mmHg either by
end-tidal or transcutaneous> 25% of total sleep time) and
hypoxemia (time spent with O2 saturation <88% >5
min) were ascertained. For infants who underwent adenotonsillectomy
(AT), we compared the SDB metrics before and after the AT. Results A
total of 40 infants were included (Mean age 6.6 months, male 66%). PSGs
consisted of diagnostic (n=13) and split night (n=27, 68%) studies. All
met criteria for OSA with mean oAHI 34.6 (32.3). Central sleep apnea was
present in 11 (27.5%) of infants. A total of 11 (27.5%) had hypoxemia.
Hypoventilation was present in 10 (25%) infants. There was a trend of
association between hypothyroidism and hypoventilation (OR: 5.5
[0.96-34.4], p=0.056). Among 13 infants who underwent AT and had a
follow up PSG, severity of OSA markedly reduced after AT (oAHI
difference: 34/hr [29], p=0.0002). Conclusion This study highlights
the high prevalence of SDB in infants with DS and supports early PSG
assessment in this patient population.
CORONARY UNROOFING DOES NOT FITS ALL ANOMALOUS AORTIC ORIGIN OF CORONARY ARTERIES.
Authors: Arcieri Luigi , Colaneri Massimo , Bianco Francesco , Merlino Ettore , Santoro Gaetano , Silvano Raffaele , Baldinelli Alessandra , Pozzi Marco
Published: March 2022

Introduction Anomalous aortic origin of coronary artery (AAOCA)
is the second leading cause of sudden cardiac death in children and
young adults. Intramural-interarterial course is the most frequent
anatomic variation and coronary unroofing is widest adopted for surgical
management. Symptoms recurrence is described regardless of the technique
used. This study aims to describe how an anatomic patient-centered
approach aimed to restore a normal coronary artery take-off is
associated with symptoms resolution. Methods From 2008 to 2021,
25 patients were operated on for an AAOCA at a median age of 20 years.
Nineteen patients had a right AAOCA and six had left AAOCA. Intramural
course was present in 18 patients. Seventy-six percent were symptomatic.
No episodes of aborted sudden cardiac death before surgery was described
in the population. Surgical technique used were coronary unroofing in 18
patients, coronary neo-ostioplasty in 3, coronary re-implantation in 3
and main pulmonary artery re-location in one. Results No
hospital mortality or re-operation was observed in our experience as
well as major complications related to surgery. Mean hospital length of
stay was 8.5 days. None of patients reported symptoms recurrence at
follow-up. Young athletes returned to play competitive sport.
Postoperative computed-tomography scan evaluation showed a general
improvement of the take-off angle. Conclusions AAOCA requires a
patient anatomic-based surgical management. There is not a single
surgical technique that can fits all anatomic subtype of AAOCA. Surgical
techniques may be selected on the base of the preoperative images and
intraoperative findings. In our experience this policy is associated
with no symptoms recurrence.
Comparison of 2-days and 7-days of prophylactic antibiotic therapy in the prevention of surgical site infection in coronary artery bypass grafting: A randomized, double-blind placebo-controlled trial
Authors: Barary Mohammad , Ganji Ghasem Faghanzadeh , Aliramaji Zahra , Sio Terence , Ebrahimpour Soheil , Bayani Masomeh , Koppolu Veerendra , Roushan Mohammad Reza Hasanjani , Sadeghi-Haddad-Zavareh Mahmoud , Vafaei Hamid Reza , Javanian Mostafa
Published: March 2022

Objectives: The current study aimed to compare the efficacy of
the two different prophylactic antibiotic regimens (2-days vs. 7-days)
in preventing surgical site infection in coronary artery bypass grafting
(CABG). Methods: Patients undergoing CABG were included
in this randomized, double-blind, placebo-controlled trial. From 2016 to
2017, 370 cases were allocated to one of two groups. The groups received
prophylactic antibiotic therapy for either 2-days or 7-days. All CABG
patients were followed for days for surgical site infections. Two of the
patients died after surgery, and 3 patients did not show up during the
three-month follow-up evaluation and thus did not meet the study
criteria. Results: Of the remaining 365 patients who participated
in the full study, 198 (54.2%) were male, and 167 (45.7%) were female
patients. The mean age of these cases was 58.64± 11.4. Of the 365 study
participants who received prophylactic antibiotics prior to surgery, 16
patients developed surgical site infections (legs and sternum). Among
these 16 patients, nine cases belong to the 7-days prophylactic
antibiotic therapy group (2.4%), and seven cases belong to the 2-day
prophylactic antibiotic therapy group (1.9%) (P=0.771).
Conclusion: Comparison of two 2-day and 7-day prophylactic
antibiotic regimens showed no significant difference in the incidence of
post-surgical infection in the two groups.
Pointwise quasi hemi-slant submanifolds
Authors: Beyendi Selahattin , Akyol Mehmet , Stankovic Mico
Published: March 2022

The objective of this paper to introduce a new class of sub- manifolds
which are called pointwise quasi hemi-slant submanifolds in almost
Hermitian manifolds which extends quasi hemi-slant, hemi-slant,
semi-slant and slant submanifolds in a very natural way. Several basic
results in this respect are proved in this paper. Moreover, we obtain
some conditions of the distributions which are involved in the denition
of the new submanifolds. We also get some results for totally geodesic
and mixed totally geodesic conditions for pointwise quasi hemi-slant
submanifolds. Finally, we illustrate some examples in order to garanty
the new kind of submanifolds.
Sigmoid colon perforation associated with retroperitoneal fluid retention after vascular surgery
Authors: Nonogaki Akira , Ihara Tsutomu , Ishida Shinichi , Asada Takahiro
Published: March 2022

A patient with retroperitoneal fluid retention after vascular surgery
had a fever of unknown cause. Re-examination suggested fluid infection.
Surgery was performed, and the patient was diagnosed with colon
perforation. If the fluid volume reduces or the fluid comes into contact
with the colon, colon perforation should be suspected.
Lieb's and Lions' type theorems on Heisenberg Group and applications
Authors: Wang Sainan
Published: March 2022

In this paper, we make an effort to establish Lieb’s and Lions’ type
theorems on Heisenberg Group, and then apply them to study the existence
of solution for variational problem on Heisenberg group.
Central mucoepidermoid carcinoma of mandible deriving from an odontogenic cyst: A case report and review of the literature
Authors: Loreti Andrea , Abate Ornella , Arelli Floriana , Spallone Diana , Bruno Edoardo , Luca Pietro De , Costarelli Leopoldo , Camaioni Angelo
Published: March 2022

Mucoepidermoid Carcinoma (MEC) it can origin from a mandibular
odontogenic cyst. We report the case of a 63-year-old man with MEC of
the right retromolar trigonum of the mandibula. We performed a wide
mandibular excision and immediate reconstruction with a fibula bone free
flap.
Cavernous hemangioma of mesentery involving the jejunum causing intestinal obstruction in an adult male
Authors: Thapa Srijana , Koirala Udaya , Joshi Bijendra , Baniya Anish , Pokhrel Bidushi
Published: March 2022

We present a rare case of 45-year-old man with complaints of abdominal
pain and features suggestive of intestinal obstruction. CT scan of the
abdomen demonstrated a large mesenteric mass in the pelvic region
involving the distal segment of jejunum. Surgical excision of the lesion
and histo-pathological examination confirmed cavernous hemangioma.
Neonatal lupus erythematosus - a rare syndrome of transient autoimmunity
Authors: Zdraveska Nikolina , Kostovski Aco , Sofijanova Aspazija , Jancevska Snezana , Jovanovska Jana , Kacarska Milena , Damevska Katerina
Published: March 2022

Neonatal lupus erythematosus (NLE) is a rare autoimmune disease due to a
passive transfer of maternal autoantibodies to the fetus. Clinical
spectrum is variable and includes skin lesions, cardiac, hematological,
or hepatobiliary disorders. We report a NLE case presenting with skin
eruption that was initially considered as tinea.
Herpes Zoster involving the maxillary branch of the right trigeminal nerve after viral vector COVID-19 vaccine: is it a possible adverse effect?
Authors: Bougossa Rebeh , Marrakchi Wafa , Maatoug Hamza , Kooli Ikbel , Brahim Hajer Ben , Aouam Abir , Toumi Adnene , Chakroun Mohamed
Published: March 2022

Many cases of VZV reactivation after mRNA and inactivated COVID-19
vaccine have been reported in the litterature We report a case of an
herpes zoster involving the maxillary nerve in a 66 year-old
immunocompetent female, that appeared 5 days after the first dose of a
viral vector COVID-19 vaccination, with a favourable outcome.
Combating COVID-19 for human cardiovascular health: From “ISISI” strategies to final victory
Authors: Hu Chunsong
Published: March 2022

The COVID-19 pandemic is still continuing. Current major variants of
SARS-CoV-2 (Delta and Omicron) have lead to new uncertainties. Since the
infection of SARS-CoV-2 and its major variants has been a high risk
factor of cardiovascular health due to major adverse cardiovascular
events (MACCE) and outcomes. Thus, the more coverage of vaccination,
enough health workers, and related medical resources as well as the
“ISISI” barriers from locals or regions to the globe play a critical
role in combating COVID-19 and protection of human cardiovascular
health.
Hidden malignancy in extremely large polycystic liver and kidney
Authors: Ito Hiroki , Hirose Takuo , Mori Takefumi
Published: March 2022

A patient with polycystic kidney disease had flank and back pain lasting
for a month. We considered that her cysts led to the pain, which is a
common symptom of polycystic kidney disease. However, a cancer hidden in
large and multiple cysts caused the pain.
Antipsychotic polypharmacy and clozapine prescribing patterns: evolution and correlates before and after a psychiatric hospitalisation
Authors: Lagreula Juliette , Timary Philippe de , Elens Laure , Dalleur Olivia
Published: March 2022

Aim: To explore the evolution of antipsychotic polypharmacy (APP) and
other psychotropic prescribing patterns during psychiatric
hospitalisations, to detect characteristics associated with APP on
admission and at discharge, and to examine clozapine prescribing
patterns. Methods: Data on adult inpatients diagnosed with schizophrenia
spectrum disorders were collected retrospectively from 6 Belgian
hospitals. Results: Of the 516 patients included, APP prescribing
increased significantly from 47.9% on hospital admission to 59.1% at
discharge. On admission and at discharge, APP was associated with prior
clozapine use (ORadmission=2.53, CI=1.1-5.84, ORdischarge=11.01,
CI=4.45-27.28), treatment with a first-generation antipsychotic
(ORadmission=26.79, CI=13.08-54.86, ORdischarge=25.2, CI=12.2-52.04),
increased antipsychotic exposure (ORadmission=8.93, CI=5.13-15.56,
ORdischarge=19.89, CI=10-39.54), and a greater number of hypno-sedatives
(ORadmission=1.88, CI=1.23-2.88, ORdischarge=4.18, CI=2.53-6.91), and
negatively associated with involuntary admission (ORadmission=0.31,
CI=0.14-0.7, ORdischarge=0.3, CI=0.13-0.68). When using an alternative
definition of monotherapy (i.e., including patients with an add-on
low-dose antipsychotic for sleep disorders), alcohol use disorder
(ORadmission=0.26, CI=0.13-0.54) and higher age (ORdischarge=0.53,
CI=0.29-0.95) were negatively associated with APP, and living in a
residential facility (ORdischarge=2.39, CI=1.21-4.71) and a higher daily
dosage of benzodiazepines during the stay (ORdischarge=1.32,
CI=1.03-1.69) increased the odds of being discharged on APP. Although
28.1% of patients were eligible for clozapine treatment, only 9.3%
were being treated with clozapine on admission, and 11% at discharge.
Seven of the ten patients with a new clozapine prescription were
directly being prescribed a combination of antipsychotics, without a
prior trial of clozapine monotherapy. Conclusion: Suboptimal
prescriptions of antipsychotics in patients with schizophrenia persist
after psychiatric hospitalisations and are associated with identifiable
characteristics.
Connectivity of sponge grounds in the deep sea: genetic diversity, gene flow and oceanographic pathways in the fan-shaped sponge Phakellia ventilabrum in the northeast Atlantic
Authors: Taboada Sergi , Whiting Connie , Wang Shuangqiang , Ríos Pilar , Davies Andrew , Mienis Furu , Kenchington Ellen , Cárdenas Paco , Cranston Alex , Koutsouveli Vasiliki , Cristobo Javier , Rapp Hans-Tore , Drewery Jim , Baldó Francisco , Morrow Christine , Picton Bernard , Xavier Joana , Arias María Belén , Riesgo Ana
Published: March 2022

Little is known about dispersal in deep-sea sponges, yet understanding
patterns of gene flow and connectivity is essential for their effective
management. Given rising pressure from harmful anthropogenic activities,
schemes that manage resource extraction whilst conserving species
diversity are increasingly necessary. Here, we used ddRADseq derived
SNPs to investigate the genetic diversity and connectivity for the
deep-sea sponge Phakellia ventilabrum across the northeast
Atlantic Ocean (from the Cantabrian Sea to Norway). The analysis of 166
individuals collected from 57 sampling stations were grouped into 17
different areas, including two MPAs, one SAC and other areas with
different levels of protection. The 4,017 neutral SNPs we uncovered
indicated high connectivity and panmixis amongst the majority of areas,
spanning a ca. 2,500-kilometre range and depths of 99–900 m. This was
likely due to the presence of strong ocean currents aiding larval
transport, as supported by our migration analysis and also by 3D
particle tracking modelling using information on the reproductive cycle
of P. ventilabrum. We also observed significant genetic
similarity between samples from the Cantabrian Sea and Roscoff (France)
as compared to the remainder of the collection areas, likely arising
from physical drivers such as prevailing current circulation patterns
and topographic features, acting as barriers for gene flow. Despite
this, our results suggest that all protected areas studied are well
connected with each other. The relatively low genetic diversity observed
in all areas, though, highlights the potential fragility of this species
to changing climates, which might compromise resilience to future
threats.
MRI prenatal diagnosis for vasa previa when inconclusive ultrasonography results come, cons and pros?
Authors: Wu Jiahan , Gahman Fatma
Published: March 2022

[Abstract] Objective To explore the MRI assistance in diagnosing of
vasa previa when inconclusive ultrasonography results come. Methods From
January 2018 to December 2021, 12 patients with suspected vasa previa
but inconclusive ultrasonography diagnoses at 23-25w or 31-33w were
enrolled into the study group. 51 patients diagnosed by ultrasonography
as mild ventriculomegaly with no vasa previa were enrolled into the
control group. Both groups had taken MRI scanning during the 3rd
trimester to check the existence of vasa previa. Placentas from both
groups were checked to confirm the existences of vasa previa immediately
at delivery, and postoperatively by pathology. Results In the 12
patients from the study group, MRI demonstrated vasa previa in 11
patients. The rest one was excluded of vasa previa by MRI. In all the 51
patients from the control group, MRI had excluded vasa previa. Pathology
examination after delivery had confirmed these MRI diagnoses. Conclusion
When inconclusive ultrasonography interpretations on vasa previa come,
MRI may offer some assistance in diagnosis.
Perceval Sutureless Valve-A limbo concept or a future trial
Authors: Bana Ajeet , Jaiswal Saurabh , Yadav Vimal , Tiwari Mukta , Sangal Anuj
Published: March 2022

Objective Aortic stenosis has traditionally been addressed with surgical
aortic valve replacement with a stented prosthesis. Several technologies
have emerged as an alternative treatment method for aortic valve
disease. Among them, Perceval Sutureless valve has been used in clinical
practice for more than a decade. The aim of this study was to evaluate
the results of Perceval Sutureless valve from single centre in Indian
population. Method Between April 2018 to December 2021, 30 elective
patients underwent aortic valve replacement with the Perceval Sutureless
valve. 19 patients had isolated AVR and 11 patients underwent AVR +
Coronary artery bypass grafting (CABG) with average grafts 2.1 ± 0.8.
Majority of isolated AVR, 12 of 19, were done by minimally invasive
approach. Result Mean age was 67.3 ± 13.8 and mean STS score was 2.7 ±
1.5. Mean aortic cross clamp time for isolated AVR and combined
procedure were 42 ± 11 and 74 ± 23 respectively. There was no
in-hospital mortality. 3 patients required ventilation for
> 24 hours. New onset left bundle branch block occurred in
4 patients which recovered before discharge in 2 patients. The peak and
mean valve gradients were satisfactory. None of implanted valve showed
para-valvular leak. Conclusion SAVR using Perceval Sutureless valve is
associated with excellent results and represent a safe and effective
treatment option for patients with severe AS. This valve also
facilitates MI approach and reduces aortic x-clamp and cardiopulmonary
bypass time.
Impacts of different vegetation in riparian buffer strips on runoff and sediment loss
Authors: Dunn * , Hawkins J.M.B. , Blackwell Martin , Zhang Yusheng , Collins Adrian
Published: March 2022

Buffer strips continue to feature in the management of agricultural
runoff and water pollution in many countries. Existing research has
explored their efficacy for reducing environmental problems in different
geoclimatic settings but, the evidence on the efficacy of different
vegetation treatments is less abundant than that for other buffer strip
characteristics, including width, and is more contradictory in nature.
With policy targets for various environmental outcomes including water
or air quality and net zero pointing to the need for conversion of
agricultural land, the need for robust experimental evidence on the
relative benefits of different vegetation types in buffer strips is now
renewed. Our experiment used a replicated plot scale facility to compare
the efficacy of 12 m wide buffer strips for controlling runoff and
suspended sediment loss during 30 sampled storms spanning 2017-2020. The
buffer strips comprised three vegetation treatments; a deep rooting
grass ( Festulolium cv. Prior), a short rotation coppice willow
and native broadleaved woodland trees. Over the duration of the
monitoring period, reductions in total runoff, compared with the
experimental control, were in the order: willow buffer strips (49%);
deciduous woodland buffer strips (46%); grass buffer strips (33%). The
corresponding reductions in suspended sediment loss, relative to the
experimental control, were ordered: willow buffer strips (44%)
> deciduous woodland buffer strips (30%) >
grass buffer strips (29%). Given the three-year duration of our new
dataset, our results should be seen as providing evidence on the impacts
during the establishment phase of the of the treatments.
Afforestation promotes aggregational differentiation of soil nutrient and microbial community in the erosive degraded ecosystem
Authors: Liu Yi , Chen Peng , Wang Li , Li Jun-Ya , Wan Wenjie , Zhang Run-Qin , Li Zhiguo
Published: March 2022

Afforestation has been viewed as the most effective natural measure to
restore the erosive degraded ecosystems. However, the role of soil
inherent heterogeneity on soil quality and microbial communities in
afforestation remains elusive. Here, three land types of soil were
collected and separated into four aggregate sizes to explore the effects
of afforestation in erosive degraded ecosystem on soil quality and
microbial community at the aggregate level. Afforestation increased soil
aggregate stability and aggregate-associated variance of soil nutrients,
e.g. OM, TN and TP. Compared to the bareland or farmland, four
nutrition-related enzyme activities, including invertase, urease,
alkaline phosphatase and catalase, were significantly enhanced in the
woodland. Interestingly, afforestation promoted the varies of bacterial
alpha-diversity with aggregate size, but had trivial impacts on fungal
alpha-diversity, indicating that the aggregational differentiation of
bacterial alpha-diversity was more sensitive in response to
afforestation than fungal alpha-diversity. For each land-use type, more
fungal taxa variation with aggregate size than bacteria. Afforestation
also enhanced more microbial taxa, especially fungal taxa, were
susceptible to soil aggregate size. Furthermore, afforestation
strengthened bacterial and fungal community dissimilarities between
adjacent aggregates and non-adjacent aggregates. Our findings contribute
to understand the fate of soil quality and microbial communities after
vegetation restoration in degraded ecosystems at the soil aggregate
scale.
Uniportal Video-Assisted Thoracoscopic Surgery for a Bronchogenic Cyst Combined with Lung Sequestration: Case Report
Authors: CHIEN YUCHING , Chen Ying-Yi
Published: March 2022

A 17-year-old male with chest tightness and dyspnea due to a unique
bronchopulmonary foregut malformation that had a bronchogenic cyst. An
extralobar lung sequestration was discovered during uniportal
thoracoscopic surgery accidently. The patient was discharged after 3
days of uneventful recovery course.