bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Anxiety on Texts Retelling in Adolescents
Authors: Privalova Irina V. , Petrova Anna A.
Published: January 2024

The signs of anxiety in ontogeny have not yet been sufficiently studied, as well as the indicators of anxiety in a certain age group in speech ontogeny. The hypothesis about the influence of schoolchildren’s anxiety on the text retelling process is set forth. Examining transcripts of oral retelling evidence that psychological conditions of adolescents affect their speech production. The material for this study was collected according to mass experiments, which were conducted in several secondary schools of the Republic of Tatarstan in 2020-2021. All in all, there were interviewed 458 students of the 5th grade aged from 11 to 12 years. Boys and girls were interviewed in almost equal proportions what allows speaking about gender representativeness. In order to design socio-psychological portraits of the respondents, there have been conducted a number of supplementary tests preceding the main interviews: the general awareness test, the anxiety test, the test on concentration and attention span, the Russian language test. Our research of anxiety of adolescents is based on the Integrative Anxiety Test which followed the Encyclopedia of Psychodiagnostics (ed. D. Raigorodsky). The main target of the experiment is to explore the alterations in the propositional structures integrity in text retelling that may happen as a result of anxiety influence. Having analyzed more than 300 text retellings, we have concluded that psychological factors may affect the mechanisms of information processing and verbalization. There are two types of anxiety manifestations in text retellings in adolescents. First, manifestations of anxiety on the superficial level which is revealed in alterations in the sound and lexical matter. Second, typical are the manifestations of anxiety on the deep level of propositions with complete change of semantic roles, appearance of additional propositional elements or fragmentation of existing propositions.
Discourse Emblems as the Object of Semiotic Analysis
Authors: Karasik Vladimir I.
Published: January 2024

The study deals with discourse emblems treated as recognizable identifying signs of communication participants. They occupy a certain place in a general system of semiotic interpretation of reality - they are indices characterizing the pragmatic vector of a sign, according to Ch. Morris. The difference between emblems and allegories or symbols consists in their main quality - the former should be immediately recognized by the people who belong to a certain culture whereas the latter may be deciphered. Emblems as a system constitute an outer form of culture. Discourse emblems are inherent in any type of communication and may be regarded as discourse type indices. Their linguistic and cultural essence is to show communication partners as belonging to the joint community. Emblems in a personal habitual discourse demonstrate a restricted communicative distance, in an institutional discourse they indicate the group status of communicative partners, and in an artistic discourse they show a multiplex extensible variety of meanings contained in the text or any art object having an aesthetic value.
Characteristics of Somatic Phraseology in E. Vodolazkin’s Novel “Lavr”: Semantics, Functional Potential, Frequency of Use
Authors: Karpinskay Natalia V. , Shkuran Oksana V. , Shkuran Sofia A.
Published: January 2024

The study selects and analyzes quantitative and qualitative indicators of somatic components retrieved from E.G. Vodolazkin’s novel «Lavr». The illustrative material reveals the universal and national value orientations of the regular and author’s somatic phraseological units. The most frequently used components-somatisms (eyes, head, soul, heart, hand, body) reflect the social and cultural experience of a Russian person and transform them into their own values, attitudes, positions, representing the sacred-mental essence of the nominations of the human body with vivid imagery, stylistic diversity. The analysis of the card file of the used somatic phraseological units demonstrates culturally marked Church Slavonisms that create expressive and emotional images of the Middle Ages and carry evaluative, aesthetic perception in the objective, existential aspects. One of the advantages of the novel is the somaticisms that perform various universal functions in the literary text, both for characterizing the appearance of the characters, the physical and physiological state, and for the conciseness of the narrative speech, for the emotive and emotional state of the main characters. The individual author’s somatic phraseological units detailing the ideological content of the literary text are presented. The analysis allows us present the author’s artistic picture of the world as a part of the linguistic picture of the world of a Russian person. The end-to-end anthropocentricity is a indicative characteristic of the somatic phraseology of the novel «Lavr». The article provides a semantic characteristic and determines the functional potential of more than two hundred and fifty somatic phraseological units used in the novel.
Research Potential of the O.A. Krylova’s Technique of Text Analysis in the Aspect of Speech Stylistics
Authors: Zaitseva Irina P.
Published: January 2024

The study analyzes the proposed by professor O.A. Krylovaʼs technique of text analysis in the aspect of speech stylistics, focused on the interpretation of non-fiction texts of various functional-stylistic affiliations, from the standpoint of the possibility of its use as one of the stages of a comprehensive linguo-poetic examination of texts representing artistic speech. Such an opportunity is created by the obvious correlation of a number of features characteristic of both types of texts, a certain transformation of which in verbal and artistic text structures is due to the priority of manifestation of the aesthetic function of language in them. The possibility of using the technique of analysis developed by O.A. Krylova, as a component of linguo-poetic analysis, is demonstrated by examining one of the lyrical texts - the poem by V. Miroshnichenko “We are Donbass, we should not complain!”. However, according to the author, this practice can be quite successfully applied in the interpretation of verbal and literary works of other genus-literary affiliation, where the language is embodied in an aesthetically complicated form: prose and drama.
The Influence of Theory of Mind on Reciprocal Behavior in 3-6-Year-Old Children: The Mediating Role of Mental Time Travel and Empathy
Authors: Li Zimi , Yang Shuhan , Zhang Xiangkui
Published: January 2024

Reciprocity, which refers to a behavior in which someone returns goods
as a consequence of having received goods beforehand. In the present
study, we investigated whether theory of mind is linked to different
type of reciprocity. Moreover, we explored whether mental time travel
and empathy mediate the relation between the theory of mind and
reciprocity. A sample of 202 children (63.9%girls, Mage=54.64months)
participated in the study. The parents completed the empathy
questionnaire, while the children completed the theory of mind, mental
time travel, and reciprocity experiments. Results indicated that theory
of mind was positively associated with different types of reciprocity.
The relationship between theory of mind and different types of
reciprocity was mediated by mental time travel and empathy. The
implications of these findings highlight the significance of social
cognitive abilities and emotional understanding in promoting positive
reciprocal interactions among children.
Extinction debt of Galápagos foundational coral associates: ENSO-related cold-water bleaching triggers community biodiversity loss and turnover
Authors: Rhoades Olivia , Brandt Margarita , Witman Jon
Published: January 2024

During a cold La Niña period (August 2007-January 2008) in the central
Galápagos archipelago, 70% of Pocillopora finger corals were bleached
across three long-term monitoring sites, affording an opportunity to
examine the impact of El Niño Southern Oscillation-related temperature
anomalies on the persistence of these corals and their associated
community of fish and mobile macroinvertebrates. Using a time series
empirical approach, we tagged and tracked the fate of 96 coral heads and
their associates. When surveyed in July 2008, live (recovered) and dead
corals supported similar levels of randomized observed species richness
and Chao 1 estimated species richness. Whereas richness on the surviving
live corals remained fairly stable, Chao 1 estimated richness on dead
corals underwent a nearly 50% increase between July and January 2009,
thereafter declining to 50% of originally surveyed richness by February
2010. This nonlinear change in species richness was largely due to
influx and decline in opportunistic generalists including pencil urchin
bioeroders, gastropod snails, and hermit crabs that colonized dead
corals and fed on sessile invertebrates and algae that had initially
recruited to dead and undefended coral substrate. Thus, dead corals
retained high overall species richness until live corals had recovered;
after which richness declined as dead corals eroded and disappeared
(July 2011). Live corals attracted a less speciose but stable assemblage
of mutualistic xanthid crabs and fishes that increased in abundance over
time with the recovery and growth of live coral tissue. Overall, three
physical features of the finger coral habitats (coral vital status,
total surface area, and maximum branch length) predicted the number of
species associated with each colony. The delayed diversity loss of
associated species following La Niña disturbance to a foundation species
represents a local extinction debt of 32-49-month duration. A better
understanding of the scale of extinction debt in foundational marine
ecosystems is needed to quantify the breadth of impacts of climate
oscillations on biodiversity and ecosystem functioning.
The effect of oral probiotics on CD4 count in patients with HIV infection undergoing treatment with ART who have had immunological failure
Authors: Mortezazadeh Masoud , kalantari Saeed , Abolghasemi Nooshin , Ranjbar Mitra , Ebrahimi Saeedeh , Mofidi Abbas , pezeshkpour Babak , Mansouri Ensieh Sadat , tabatabaei seyed zia , KASHANI MEHDI
Published: January 2024

Introduction: Probiotics are live microorganisms that, when administered
in appropriate colonies, can delay the destruction of the immune system
and contribute to the maintenance of immunity in HIV patients.
Probiotics play an important role in stimulating natural killer T cells,
strengthening the functional gut barrier, and reducing systemic
inflammation. Methods: This study was a randomized double blind clinical
trial involving 30 patients treated with ART who had experienced
immunological failure despite HIV viral suppression. Patients were
divided into two equal groups of 15, the first group received 2
probiotic capsules daily with a colony count of 10⁹CFU per capsule
containing seven strains ,after three months they were examined for CD4+
counts by flow cytometry, after a one month washout period the
participants who had received probiotics were switched to placebo, and
the participants who had received placebo were given probiotics for
three months, and they were examined for CD4+ counts seven months after
the start of the study. Results: In the first group, administration of
the placebo resulted in a decrease in CD4 count in the first three
months (from 202.21 to 181.79, p-value < 0.001),which may be
due to the natural history of the disease. After probiotics
administration, CD4 count increased significantly (from 181.79 to
243.86, p-value < 0.001). Overall, after 7 months of study,
there was a significant increase in the mean CD count from 202.21 to
243.86 (p-value < 0.001). In the second group, administration
of probiotics in the first three months of the study resulted in a
significant increase in the mean CD4 count (from 126.45 to 175.73,
p-value < 0.001).Termination of treatment with probiotics
resulted in a significant decrease (from 175.73 to 138.9, p-value
< 0.001)but overall the CD4 count at the end of the study was
significantly higher than at baseline (p-value < 0.001).
Behçet syndrome: The disturbed balance between anti- (CLEC12A, CLC) and pro-inflammatory (IFI27) gene expressions
Authors: Oguz Ali Kemal , Oygür Çağdaş Şahap , Taşır Seda , Sevgili Hilal Özdağ , Akar Mehmet Nejat
Published: January 2024

Behçet syndrome (BS) is a chronic, multisystemic inflammatory condition
with unanswered questions regarding its pathogenesis and rational
therapeutics. A microarray-based comparative transcriptomic analysis was
performed to elucidate the molecular mechanisms of BS and identify any
potential therapeutic targets. Twenty-nine BS patients (B) and 15 age
and sex-matched control subjects (C) were recruited. Patients were
grouped as mucocutaneous (M), ocular (O), and vascular (V) according to
their clinical phenotypes. GeneChip Human Genome U133 Plus 2.0 arrays
were used for expression profiling on peripheral blood samples of the
patients and the control subjects. Following documentation of the
differentially expressed gene (DEG) sets, the data were further
evaluated with bioinformatics analysis, visualization, and enrichment
tools. Validation of the microarray data was performed using qRT-PCR.
When P ≤0.05 and fold change ≥2.0 were chosen, the following numbers of
DEGs were obtained; B vs. C: 28, M vs. C: 20, O vs. C: 8, V vs. C: 555,
M vs. O: 6, M vs. V: 324, O vs. V: 142. Venn diagram analysis indicated
only two genes, CLEC12A and IFI27, in the intersection of M vs. C and O
vs. C and V vs. C. Another noteworthy gene appeared as CLC in the DEG
sets. Cluster analyses successfully clustered distinct clinical
phenotypes of BS. While innate immunity-related processes were enriched
in the M group, adaptive immunity-specific processes were significantly
enriched in the O and V groups. Distinct clinical phenotypes of BS
patients displayed distinct expression profiles. In Turkish BS patients,
expression differences regarding the genes CLEC12A, IFI27, and CLC
seemed to be operative in the disease pathogenesis. Based on these
findings, future research should consider the immunogenetic
heterogeneity of BS clinical phenotypes. Two anti-inflammatory genes,
namely CLEC12A and CLC, may be valuable as therapeutic targets and may
also help design an experimental model in BS.
Prevalence and Predictors of Early Intervention Referral Among Substance Exposed Newborns
Authors: Bourque Stephanie , Weikel Blair , Hwang Sunah
Published: January 2024

Substance exposed newborns (SENs) are at risk of developmental delay(s).
Early intervention (EI) access, key to addressing these risks, is
inequitable. Objectives were to determine prevalence of EI referral in
the Colorado Hospitals Substance Exposed Newborn (CHoSEN) Quality
Improvement Collaborative (USA) and evaluate predictors of referral.
Maternal-infant dyads with exposure to medications for opioid use
disorder (MOUD), illicit/prescription opioids, and/or non-opioid
substances were included. Chi-square, Fisher’s exact, and ANOVA tests
evaluated differences in maternal/infant characteristics by referral.
Multivariable logistic regression models assessed the independent
association of characteristics with referral. Among 991 primarily White,
non-Hispanic dyads, 407 (41.1%) SENs received EI referral. Infants born
to mothers with non-MOUD (AOR 0.22, 95% CI 0.10, 0.45) and
polysubstance (AOR 0.60, 95% CI 0.36, 0.98) exposure were less likely
to receive referral compared to infants born to mothers with MOUD
exposure. Those with shorter length of stay of 1-3 days (AOR 0.03, 95%
CI 0.01, 0.07) and 4-6 days (AOR 0.47, 95% CI 0.32, 0.69) were less
likely to receive referral compared to infants admitted >6
days. Less than half of identified SENs received EI referral with
variation by substance exposure and length of stay. Systems to ensure
equitable access to services are crucial.
Epidermal characters of Rosa L. and Rubus L. (Rosaceae) from Iraq and their taxonomic value.
Authors: Sadeeq zeravan
Published: January 2024

ABSTRACT The leaf epidermal structure of thirteen taxa from the genera
Rosa L. and Rubus L. (Rosaceae family), which grow obviously within the
Kurdistan Region of Iraq, is investigated via light microscopy. All taxa
have the type of anomocytic stomata on the abaxial surface, and no
stomata are present on the adaxial surface. Within the genus Rubus, R.
sanctus can be distinguished from R. caesuis by the anticlinal wall
patterns on the adaxial and abaxial surfaces and the shape of the
epidermal cells on the abaxial side. In Rosa, the shape of the epidermal
cells on the abaxial surface varies from polygonal and
polygonal-slightly irregular to irregular. R. canina var. deseglsei can
be recognized by the abaxial surface’s anticlinal wall pattern and the
epidermal cells’ shape. Although R. foetida had larger epidermal cell
densities on all surfaces, it lacked the necessary taxonomical support
to distinguish our Rosa genus taxa. Stomatal density as a range and
stomata index could be valuable two diagnostic features for separating
R. hemispharica from the remaining taxa of the genus Rosa. The taxa of
Section: Pimpinellifoliae can be separate by the patterns of anticlinal
walls of the abaxial surface from the remaining taxa of Sections:
Caninae and Gallicanae within Subgenus: Rosa under study. According to
our findings, some leaf epidermal characteristics and stomata are
advantageous for distinguishing the various taxonomic ranks of the
genera Rosa and Rubus family Rosaceae.
Basic Number Knowledge Predicts Later Phonological Processing in Kindergarten Children
Authors: Ma Chi , Chen Xin , Yang Xiujie
Published: January 2024

An ongoing debate on the association of numerical cognition and
phonological processing concerns the extent to which they influence each
other during number acquisitions. The current study aims at establishing
the direction of the developmental relationship between these two kinds
of abilities at an early age. Eighty-two Chinese kindergarten children
were followed from 5 to 6 years old with a one-year interval. We
investigated three phonological processing skills (phonological
awareness, phonological memory, and rapid automatized naming) and two
kinds of basic number knowledge (number identification and number
comparison) at time 1 and time 2. Cross-lagged panel analyses revealed
that the association between phonological awareness and number
comparison was bidirectional. Moreover, early phonological awareness at
time 1 could predict later number identification, and early number
comparison at time 1 was a significant predictor of later phonological
memory. In contrast, rapid automatized naming had no such predictive
relations with other variables. The present findings are the first to
provide longitudinal evidence that basic number knowledge could predict
later phonological processing in kindergarten children.
Prevalence and bidirectional association between rhinitis and urticaria: A systematic review and meta-analysis
Authors: Yongjun Peng , Xu Shuying , Ni Siming , Zeng Chunli
Published: January 2024

Background: Rhinitis, allergic rhinitis in particular, and urticaria are
both common atopic problems globally. However, there is controversy
regarding the correlation between rhinits and urticaria. Objectives: To
examine the accurate association between rhinitis and urticaria.
Methods: Three medical databases (PubMed, Embase, and Web of Science)
were searched from database inception until January 11, 2022. The
prevalence and association between rhinitis and urticaria were estimated
by meta-analysis. The Preferred Reporting Items for Systematic Reviews
and Meta-analyses guidelines were followed, and quality assessment was
performed using the Newcastle–Ottawa Scale. Pooled odds ratios (OR)
with 95% confidence intervals (95% CI) and pooled prevalence were
calculated using random-effects models. Results: Urticaria prevalence in
patients with rhinitis was 17.6% (95% CI, 13.2%–21.9%). The pooled
prevalence of rhinitis was 31.3% (95% CI, 24.2%–38.4%) in patients
with urticaria, and rhinitis prevalence in patients with acute urticaria
and chronic urticaria was 31.6% (95% CI, 7.4%–55.8%) and 28.7%
(95% CI, 20.4%–36.9%), respectively. Rhinitis occurence was
significantly associated with urticaria (OR, 2.67; 95% CI,
2.625–2.715). Limitations: Urticaria and rhinitis were diagnosed based
on different criteria possibly resulting in a potential
misclassification of these two diseases. Conclusion: Rhinitis and
urticaria were significantly correlated. Physicians should be cognizant
regarding this relationship and address nasal or skin symptoms in
patients.
A new species of smooth-spored Inocybe from Conifers forests of Pakistan
Authors: Naseer Arooj , Razzaq Annum , Saeed Mubashara , Khalid Abdul
Published: January 2024

A new species in genus Inocybe is described and illustrated from
Himalayan Moist Temperate forests of Pakistan. It is characterized by
fibrillose, conical to convex, umbonate, brown to dark brown pileus,
non-pruinose, fibrillose stipe with whitish tomentum at base,
basidiospores smooth and comparatively larger (9 × 5.2 µm) and thicker
caulocystidia (upto 21 m). Phylogenetic analyses of nuc rDNA region
encompassing the internal transcribed spacers 1 and 2 along with 5.8S
rDNA (ITS) and nuc 28S rDNA D1-D2 domains (28S) also confirmed its
novelty.
Ras Family Signaling Pathway in Immunopathogenesis of Inflammatory Rheumatic Diseases
Authors: Farhadi Elham , Shaker Mina Sadeghi , Rokni Mohsen , Mahmoudi Mahdi
Published: January 2024

The Ras (rat sarcoma virus) is a GTP-binding protein which considered
one of the substantial membranes of the Ras-GTPase superfamily. The Ras
involves several pathways in the cell that include proliferation,
migration, survival, differentiation, and fibrosis. Abnormalities in the
expression level and activation of the Ras family signaling pathway and
its downstream kinases such as Raf/MEK/ERK1-2 contribute to the
pathogenic mechanisms of rheumatic diseases including immune system
dysregulation, inflammation, and fibrosis in systemic sclerosis (SSc),
destruction and inflammation of synovial tissue in rheumatoid arthritis
(RA), auto-antibodies production and immune complexes formation in
systemic lupus erythematosus (SLE), and enhances osteoblast
differentiation and ossification during skeletal formation in AS. In
this review, the basic biology, signaling of Ras, and abnormalities in
this pathway in rheumatic diseases including SSc, RA, AS, and SLE will
be discussed.
Yoga in the Neonatal Intensive Care Unit for parents: a needs assessment and acceptability study
Authors: Neches Sara , Perez Krystle , Puia-Dumitrescu Mihai , Mayock Dennis , Umoren Rachel , Juul Sandra
Published: January 2024

Aim: To explore NICU parent and staff attitudes towards yoga for parents
as a stress reduction intervention and determine the acceptability of an
online yoga curriculum. Methods: A 13-item survey on yoga for parents
was emailed to clinical and non-clinical staff at two level IV NICUs.
Another 40-item survey was distributed to parents via linked QR code in
both units. Results were used to determine feasibility of a 6-week
online yoga curriculum for NICU parents. Results: 54 parent and 140
staff surveys were completed between Jan 2021-Mar 2022. Many NICU
parents self-reported stress (n=40, 74%) and anxiety (n=35, 64%).
Thirty-seven (68%) parents had practiced yoga and 13% used yoga as a
coping strategy. A total of 114 (81%) staff members practiced yoga and
thought yoga decreased stress (n=125, 89%) and anxiety (n=100, 71%).
Most responders (97%) with any experience with yoga supported a yoga
intervention for parents. 71% of parents supported online classes.
Identified barriers from staff included liability (n=28, 20%), cost
(n=30, 21%) and safety (n=44, 31%). Parents cited stress (n=1,17%),
lack of time (n=2, 33%) and inexperience (n=1,17%) as barriers.
Conclusion: Online yoga classes may be an innovative approach to address
parental stress and anxiety during NICU hospitalization.
Distribution and Chemotactic Mechanism of CD4+ T Cells in Traumatic Tracheal Stenosis
Authors: feng tingmei , chen yan , wei jinmei , tan sen , guangnan liu
Published: January 2024

Abstract: A systemic and local inflammatory immune imbalance is thought
to be the cause of traumatic tracheal stenosis (TS). However, with CD4+
T lymphocytes being the predominant immune cells in TS, the mechanism of
action and recruitment has not been described. In our research, using
flow cytometry, ELISA, immunofluorescence, and Transwell chamber assays,
the expression, distribution, and potential chemotactic function of CD4+
T cells in TS patients were examined before and after treatment. The
results showed that the untreated group had significantly more CD4+ T
cells and their secreted TGF-β1 than the treated group. Additionally,
the untreated group’s CD4+ T cells showed a significant rise in CCL22
and CCL1, as well as a larger proportion of CCR4 and CCR8. CD4+ T cells
and CD68+ macrophages located in TS also expressed CCL1 and CCL22. In
vitro, anti-CCL1 and anti-CCL22 can partially block the chemoattractant
effect of TS bronchoalveolar lavage (BAL) on purified CD4+ T cells. The
findings of this study indicated that TS contained unbalanced CD4 immune
cells that were actively recruited locally by CCR4/CCL22 and CCR8/CCL1.
As a result, it is anticipated that CD4 immune rebalancing can serve as
a novel treatment for TS.
The effect of relative accuracy and social characteristic strength on children's selective trust
Authors: Huang Chenshan , He Zhifang , Wei Yanping , Chen Shuiping
Published: January 2024

Two experiment examined the effect of relative accuracy and social
characteristic strength on selective trust in young children aged 4-6.
Experiment 1 manipulated relative accuracy, the results revealed that
when the accuracy difference is relatively small, children’s choice of
accurate dissenter turned into: 4 and 5 years old children chose
consensus with low accuracy, 6 years old children chose dissenter with
high accuracy ; Experiment 2 manipulated the strength of social
characteristics, the results revealed that when the social
characteristics were enhanced, 4 and 5 years old children chose smiling
inaccurate consensus, 6 year old children chose serious accurate lone
informant. To sum up, in conflict situations, relative accuracy and
social characteristic strength can all influence children’s selective
trust; moreover, this study further verified that the ability to make
rational decisions of children would be more and more rational with age.
Hydrothermal carbonization induced oxygen vacancies on hematite for boosting photo-Fenton performance
Authors: Li Yaru , Ding Tianqi , Jiao Han , Na Ping , Ding Yi , Wang Xianbiao
Published: January 2024

Introduction and stabilization of oxygen vacancies on hematite is an
effective strategy for boosting photo-Fenton performance. Herein, a
novel hydrothermal carbonization process was utilized to induce oxygen
vacancies on hematite to obtain amorphous carbon encapsulated core-shell
composite (Fe2O3-x@AC), using ascorbic acid as reducing agent and carbon
source. Amorphous carbon was coated on hematite by Fe-O-C bond with a
mass fraction of 10.2 wt%. Compared with commercial hematite, the
signal appeared at g=2.003 in EPR spectrum of Fe2O3-x@AC composite,
confirming the formation of oxygen vacancies (Vo). Thanks to the
introduction of AC and Vo, Fe2O3-x@AC composite showed excellent
photo-Fenton activities, and its photo-Fenton degradation rate for RhB
and phenol were increased to 7 and 70 times of commercial hematite. •OH
generated from heterogeneous photo-Fenton reaction of Fe2O3-x@AC
catalyst is the dominant reactive radical for organic pollutants
degradation. The improvement of photo-Fenton properties of Fe2O3-x@AC is
mainly attributed to the synergistic effect of AC and Vo, in which the
decomposition of H2O2 to produce •OH was promoted to enhance the
oxidation ability, and the charge transfer ability and carrier density
were increased to accelerate the reaction. This work will give new light
for the defect engineering of photo-Fenton catalysts with improved
reactivity.
Primulina pingguoensis, a new species of Gesneriaceae from Guangxi, China
Authors: Ma Hu-Sheng , Lu Zhao-Cen , Xu Wei-Bin , Pan Bo
Published: January 2024

Primulina pingguoensis H.S. Ma & B. Pan, a new species of Gesneriaceae
from Guangxi Zhuang Autonomous Region, China, is illustrated and
described here. The new species morphologically resembles Primulina
carinata Y.G. Wei, F. Wen & H.Z. Lü, but it differs from the latter by
leaf blade elliptic to broadly ovate, 6.5–9.5 × 4.5–6.5 cm (vs.
broadly elliptic to ovate, 4.0–5.0 × 3.0–4.0 cm), leaf blade base
slightly oblique, cuneate (vs. rounded), leaf blade carnose (vs.
subcoriaceous), corolla pinkish purple to pink (vs.purple or purplish
red), corolla tube tubular, ventrally carinate, (vs. narrowly
funnelform, strongly carinate, forming a clear keel), staminodes 2 (vs.
3). etc. The conservation status of P. pingguoensis is considered as
‘Critically Endangered’ (CR) according to the IUCN red list categories
and criteria.
Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery
Authors: Yang Shuang , Zhou Chengbin , Zhang Lei , Xiong Yueting , Zheng Yongtao , Bian Liuguan , liu xiaohui
Published: January 2024

Purpose: Brain tumors, whether primary or secondary, have limited
information about proteomic changes despite advances in the
understanding of the driver gene mutations and heterogeneity within
tumor cells. The purpose of this study is to distinguish primary and
secondary brain tumors based on proteomics. Experimental Design: We
assembled the most common primary tumors as follows: gliomas from WHO
grade II to IV with or without IDH1 mutations; and BrMs with a wide
range, including lung cancer (L.C), breast cancer (B.C), ovarian cancer
(O.C), and colorectal cancer (C.C). A total of 29 tissue samples were
analyzed by label free quantitative mass spectrometry-based proteomics.
Results: In total, 8,370 protein groups were identified, and
approximately 4,000 quantified protein groups were adopted for further
analysis. Proteomic analysis of metastatic tumors reveals conserved
features across multiple cancers. While proteomic heterogeneities were
found for discriminating low- and high-grade of gliomas, as well as IDH1
mutant and wild-type gliomas. And distinct pathway-level differences
among these two types of brain malignancies were revealed. The
characteristic pathways of BrMs focused on proliferation and
immunomodulation after colonizing the brain, whereas invasion processes
were notably activated in gliomas. Conclusions and Clinical Relevance:
We elucidated an extensive proteomic landscape of BrMs and gliomas,
providing information for the development of potential therapeutic and
diagnostic strategies for type-specific brain tumors.
Characterization of secretory phospholipase A2 inhibitory activity in Tragia hispida as potential therapeutic agent for treatment of dengue
Authors: Hemalika D. V. Dayangi , Chandrika Udumalagala , Abeysekera Ajita M. , Samarakoon Sameera , Wijewickrama A. , Malavige Gathsaurie Neelika
Published: January 2024

Background: As secretory phospholipase A2 (sPLA2) was shown to be
elevated in patients who progress to severe dengue, it would be
important to evaluate the usefulness of therapeutics that inhibit sPLA2
enzymes to prevent progression to severe dengue. Methods: Aqueous and
butanol extracts of Tragia hispida, Justicia adathoda and tubers of
Cyperus rotundus were screened for the presence of potential sPLA2
inhibitors using a commercial assay measuring sPLA2 activity. Results:
Both the aqueous (THA) and butanol extracts (THB) of Tragia hispida had
sPLA2 inhibition levels comparable to the levels seen with the
commercial sPLA2 inhibitor CAY10590. THB at concentrations of 0.1 µg/µL
and 0.2 µg/µL, significantly reduced the sPLA2 activity
(p<0.0001) in the sera of dengue patients and the inhibitory
activity was significantly higher (p<0.0001) than of CAY10590.
Thin layer chromatography of THB showed that it was likely to contain a
mixture of flavonoid and phenolic compounds. HPLC displayed peaks at
3.207 min (λmax 222 nm, 272 nm) and 7.972 min (λmax 224 nm, 272 nm)
which were most likely to represent phenolics and peaks at 11.883 min
(λmax 276 nm, 366 nm) and 16.898 min ( λmax 254 nm, 370 nm) which were
most likely to represent flavonoids. Conclusions: T. hispida aqueous and
butanol soluble fraction had potent sPLA2 inhibitory activities, which
should be further explored for their potential to be used for treatment
of dengue.
Digital PCR for absolute quantification of cell-free DNA introduces new aspects in the surveillance of patients after heart transplantation: clinical scenarios
Authors: Bohmer Jens , Wåhlander Håkan , Karason Kristjan , Sunnegårdh Jan , Wasslavik Carina , Jonsson Marianne , Asp Julia , Ricksten Anne , Dellgren Goran
Published: January 2024

Background: Heart transplantation (HTx) relies on an endomyocardial
biopsy for rejection surveillance. Cell-free DNA (cfDNA) is released
into the circulatory system from the cells of the recipient
(recipient-derived rd-cfDNA) as well as from the graft (donor-derived
dd-cfDNA) and is determined by the analysis of a blood test. There is
growing evidence that the donor fraction (DF, the ratio of dd-cfDNA to
all cfDNA) corresponds to the integrity of the graft. However, it is
important that rd-cfDNA levels vary greatly in different, sometimes
clinically silent circumstances, which in turn makes DF the sole measure
of graft status vulnerable to bias. Methods: Using a digital PCR-based
method that allowed us to quantify separate values of rd-cfDNA,
dd-cfDNA, and DF, we investigated a prospective cohort of 52 patients
during their first year after HTx. Results: We found median DF levels of
approximately 0.1%, which is in accordance with the literature. We
present patients with various clinical scenarios after HTx, including an
uncomplicated clinical course, several infections (viral and bacterial),
acute and chronic rejection, and false-negative and false-positive
rejections. Conclusions: Quantification of circulating cfDNA reflects a
live-view of cell turnaround in the recipient and graft. Measuring the
DF alone may not be sufficient to fully understand the complex biology
of cfDNA after HTx.
Privacy preserving vaccinating- and testing-pass for the European Union
Authors: Schrahe Dominik , Städter Thomas
Published: January 2024

Physicians and scientists hope that health-data will provide new
insights into improving medical care and optimizing healthcare costs.
However, data protection laws in Europe often place limits on the use of
patient data. During the COVID-19 pandemic, both digital immunity
records and data on infections were needed for pandemic management.
Using this example, the research project aims to create a system concept
for vaccination, testing, and recovery proof called P3VT (Privacy
Preserving Pass for Vaccination and Testing), that will make collected
data available to research and policy pandemic management in real time
and anonymized. P3VT was developed consistently considering the goals of
privacy-by-design, data minimisation and transparency of the EU-GDPR.
Expert interviews validated the system from medical, technical and
privacy perspectives. P3VT offers the following advantages compared to
the EU digital COVID certificate: Pseudonymized proof of vaccination,
testing, and recovery, reducing misuse of sensitive personal data
Transparency about the nature, timing, and purpose of the proof
strengthens user trust Use of anonymous data improves pandemic
management, and research P3VT is thus an exemplary solution for the
comprehensive provision of health-data for research purposes in
combination with high level of data protection. Further areas of
application are conceivable.
Chemokine Receptors Expression on Peripheral CD4-Lymphocytes in Rheumatoid Arthritis: CD4+CD183+ As A Diagnostics Marker for Disease Activity in Rheumatoid Arthritis
Authors: Sakyi Samuel Asamoah , Buckman Tonnies Abeku , Yeboah-Mensah Kwame , Antwi-Berko Daniel , Effah Alfred , Senu Ebenezer , Dey Dzifa , Antwi Maxwell , Yorke Joseph , Boateng Andy , Addei Akwasi , Tanko Muniru , Boateng Richard
Published: January 2024

Background: T cell chemokines and its receptors play important roles in
the development and progression of rheumatoid arthritis (RA). Their
involvement has been reported in inflammatory autoimmune diseases.
However, their role in RA in the Ghanaian population has not been
explored. We evaluated the intracytoplasmic CD4+ T cell chemokine
receptors in rheumatoid arthritis patients in Ghana and determined their
relationship with disease activity. Methods. This case control study
included 48 newly diagnosed RA patients and 30 apparent healthy controls
from the orthopaedic units of Komfo Anokye Teaching Hospital (KATH),
Kumasi and Korle-Bu Teaching Hospital (KBTH), Accra, Ghana. A
well-structured questionnaire was used to obtain sociodemographic data.
Blood samples were also collected and processed for flow cytometric
analysis. Statistical analyses were done using SPSS version 26.0 and R
programming language. Results: This study found a significant difference
in age group (p < 0.0001), marital status (p ¬= 0.0210),
occupation (p = 0.0140), educational level (p = 0.0210) and religion (p
= 0.0100) between RA patients and healthy controls. Moreover,
haemoglobin level (p = 0.0010), waist circumference (p <
0.0001) and hip circumference (p = 0.0040) were significantly different
between RA patients and healthy controls. RA patients had significantly
lower levels of CD4+CD183+ compared to the control group (p <
0.001), and was positively correlated with DAS score (r = 0.0397, p =
0.789). In Receiver Operator Characteristics analysis, CD4+CD183+ could
significantly detect rheumatoid arthritis with a very high area under
the curve (AUC = 0.687, p = 0.018). At a cut-off of 0.082, CD4+CD183+
was the best chemokine receptor for detecting RA with a sensitivity of
90.0%, specificity of 25.9%, a positive predictive value of 69.2%,
and a negative predictive value of 58.3%. Conclusion: CD4+CD183+ could
serve as useful diagnostics and disease-monitoring marker for rheumatoid
arthritis in the Ghanaian population.
First report of the Half beaks Hemiramphus far (Forsskål 1775)
Authors: TELAILIA Salah , BOUZID Riad , ZAIDI Raouf , BOUTABIA Lamia
Published: January 2024

Hemiramphus far (Forsskål, 1775) is a marine non-migratory fish,
caracterised by a greatly prolonged, beak-like lower jaw, a short upper
jaw, native in the Indo-West Pacific, but which has been observed in
different places in the Mediterranean, due to the different climatic
changes, as is the case of the present report in the east coast of
Algeria .
Developing a context-relevant psychosocial stimulation intervention to promote cognitive development of children with severe acute malnutrition in Mwanza, Tanzania
Authors: Jensen Cecilie Louise , Sanga E. , Kitt H. , Praygod G. , Kunzi H. , Setebe T. , Filteau Suzanne , Webster J. , Gladstone Melissa , Olsen M. F.
Published: January 2024

More than 250 million children will not meet their developmental
potential due to poverty and malnutrition. Psychosocial stimulation (PS)
has shown promising effects for improving development in children
exposed to severe acute malnutrition (SAM) but programs are rarely
implemented. In this study, we used qualitative methods to inform the
development of a PS programme to be integrated with SAM treatment in
Mwanza, Tanzania. We conducted in-depth interviews with seven caregivers
of children recently treated for SAM and nine professionals in early
child development. We used thematic content analysis and group feedback
sessions and organised our results within the Nurturing Care Framework.
Common barriers to stimulate child development included financial and
food insecurity, competing time demands, low awareness about importance
of responsive caregiving and stimulating environment, poor father
involvement, and gender inequality. Caregivers and professionals
suggested that community-based support after SAM treatment and
counselling on PS would be helpful, e.g. how to create homemade toys and
stimulate through involvement in everyday chores. Based on the findings
of this study we developed a context-relevant PS programme. Some issues
identified were structural highlighting the need for programmes to be
linked with broader supportive initiatives.
Predictive value of haematological indices on incidence and severity of pulmonary embolism in COVID-19 patients
Authors: Radkhah Hanieh , Mansouri Ensieh Sadat , Anaraki Shiva Rahimipour , Gholizadeh Milad , Sheikhy Ali , Khadembashiri Mohamad Mehdi , Khadembashiri Mohamad Amin , Eslami Mohamad , Mahmoodi Tara , Inanloo Behnaz
Published: January 2024

Background: Pulmonary thromboembolism (PTE) is a common complication of
SARS-CoV-2, which raises the COVID-19 disease’s fatality rate from 3%
to 45%. Nevertheless, due to fairly indistinguishable clinical symptoms
and a lack of validated clinical prediction models, PTE diagnosis in
COVID-19 patients is challenging. This study aims to investigate the
applicability of hematological indices to predict PTE incidence and its
severity in SARS-CoV-2 patients. Methods: A retrospective cohort study
was conducted on hospitalized patients with a confirmed diagnosis of
SARS-CoV-2 infection who underwent CT angiography to assess probable PTE
in them. The correlation between CBC parameters one day prior to CT
angiography and CT angiography outcomes, and simplified Pulmonary
Embolism Severity Index (s-PESI) was investigated. Results: We
discovered that among individuals with a probable PTE, males and those
with higher platelet-to-lymphocyte (PLR) and neutrophil-to-lymphocyte
(NLR) ratios had a greater likelihood of PTE incidence. PLR was a
significant and independent predictor of PTE. Moreover, a higher
neutrophil count was associated with a higher s-PESI score in COVID-19
patients developing PTE. Conclusions: Among haematological indices, NLR
and more precisely PLR are cost-effective and simply calculable markers
that can assist physicians in determining whether or not COVID-19
patients with clinically probable PTE require CT angiography and the
higher neutrophil count can be employed as an indicator of PTE severity
in COVID-19 patients. Further large multicenter and prospective studies
are warranted to corroborate these observations.
Crotolaria nicobarica (Fabaceae): A new species from Andaman and Nicobar Islands, India
Authors: Saleem Fouziya , Singh Lal , Subramaniam Shweta , Pandey Arun
Published: January 2024

Crotalaria nicobarica F. Saleem, L.J. Singh, S. Subramaniam & A. K.
Pandey is described and illustrated from tropical evergreen forest of
Great Nicobar Island, Andaman and Nicobar Islands, India. This new
species closely resembles Crotalaria lunulata Heyne ex Wight &Arn.,
Crotalaria paniculata Willd. and Crotalaria ramosissima Roxb. which
occurs in the Western and Eastern peninsular India and occupies forest
edges and cut-slopes of hillocks. The new species is distinguishable
from the latter two based on morphological characters. An analysis shows
that the new species differs from closely related species with respect
to vegetative and reproductive characters. Based on the hairy surface of
plants, persistent bracts and bracteoles, silky pubescence of vexillum
and style, oblong stalked pods the species is hypothesized to be a new
member of the Crotalaria section Crotalaria.
Developmental predictors of mathematics achievement at the end of Year 1
Authors: Martins Sara , Araújo Carolina A. , Fonseca Marisa , Baptista Joana , Martins Carla
Published: January 2024

This study examined the predictive role of child cognitive, social,
emotional, and behavioral dimensions assessed at the age of 4 ½, as well
as of academic school readiness before the entry to primary school, on
mathematics achievement at the end of Year 1. A sample of 58 children
and their parents participated in this longitudinal study. Initial
correlations indicated significant associations between child
intelligence quotient (IQ), inhibitory control, set-shifting,
dysregulation profile, academic school readiness, and their subsequent
performance in mathematics. A hierarchical regression analysis showed
that inhibitory control at 4 ½ years significantly predicted mathematics
achievement at the end of Year 1 over and above the effect of academic
school readiness before entering primary school. These results add to
the existing literature by highlighting the impact of child executive
functioning assessed during the preschool years on subsequent
mathematics performance in early school years.
Recent Advances in the Synthesis of Heterocycles from 2-Acylbenzoic Acids
Authors: Liu Yufeng , Li Cui , Yang Guoping
Published: January 2024

Heterocyclics are the crucial scaffolds present in pharmaceuticals,
natural products, biologically active compounds and agrochemicals.
Consequently, the development of simple and practical methods for
constructing heterocyclics has always been a fascinating field in
organic synthesis. Recently, 2-acylbenzoic acids as highly reactive and
versatile synthons have been broadly applied in the construction of
heterocycles due to their multiple reaction sites. In this review, we
summarized recent progress in the application of 2-acylbenzoic acids for
the synthesis of heterocycles including phthalides, isochromanones,
isoindolines, phthalazinones, and quinolones. The sub-strate scopes,
proposed mechanisms, and product application of different types of
reactions are discussed.
Father-Infant Synchrony and Infant Vagal Tone as an Index of Emotion Regulation: Father-Infant Shared Times in Switzerland as Moderators
Authors: Puglisi Nilo , Tissot Herve , Rattaz Valentine , Epiney Manuella , Razurel Chantal , Favez Nicolas
Published: January 2024

Research has shown that the quality of mother-infant interactions, such
as the way the mother and the infant are in synchrony during
interactions, is associated with infants’ vagal tone, a physiological
indicator of emotion regulation. However, little is known about the
association between the infant’s vagal tone and the quality of
father-infant interactions. The existing literature suggests that the
greater quantity of time a father spends with the infant, either alone
(dyadic time) or with others (social time) may strengthen the
association between the quality of father-infant interactions and infant
emotion regulation. In this study, we aimed to investigate the
association between father-infant synchrony and infants’ vagal tone
during interactions and whether dyadic time and social time have a
moderating role. Fathers (N = 77) and 3-month-old infants were observed
interacting and the infants’ electrocardiogram was recorded to compute
indices of vagal tone. Fathers reported dyadic and social time in
questionnaires. Results showed that father-infant synchrony has no
direct associations with infants’ vagal tone. Moderation analyses
revealed that more social time increases the association between
synchrony and vagal tone. This study suggests that the interactive
processes during shared family time may influence dyadic father-infant
interactions and the infant’s vagal regulation.
Addition of new phorophytic species hosting epiphytic orchid, Taprobanea spathulata (L.) Christ. [=Vanda spathulata (L.) Spreng. ] (Orchidaceae) from southern Western Ghats of Tamilnadu
Authors: Mayakrishnan Balachandar , Ravichandran Koshila Ravi , Ramesh Vishnu Kumar , Thangavelu Muthukumar
Published: January 2024

Taprobanea spathulata (L.) Christ. is a tropical epiphytic orchid known
for its large and fascinating flowers. During a regular survey of
succulent species in the Western Ghats region, we observed T. spathulata
growing on new phorophytes belonging to different plant families in the
Madukkarai Hills of Tamilnadu, India. In the present study, new
phorophytes like Canthium coromandelicum (Burm.f.) Alston, Euphorbia
tortilis Rottler ex Ainslie, and Pavonia zeylonica (L.) Cav. was
recorded for T. spathulata. The exploration of the new phorophytes of
different habits would be beneficial for the management and conservation
of T. spathulata.