bluuebunny/crossref_metadata_2025 huggingface dataset:
Elexacaftor/ivacaftor/tezacaftor effect on microbial density and the microbiome composition.
Authors: Fireizen Yaron , Ovunc Bugsu , Randhawa Inderpal , Krumbeck Janina , Marsteller Nathan , Bangol Celeste , Batra Jagmohan
Published: August 2022

Introduction Previous generations of CFTR modulation have been shown to
temporarily decrease the frequency of culture positivity of P.
aeruginosa and other respiratory pathogens. Recently, a three-drug
combination Trikafta (elexacaftor/ivacaftor/tezacaftor) was approved for
individuals with at least one F508del mutation. There is limited data on
the effect of CFTR modulators on bacterial density and CF microbiome.
Methods Our study included 2 separate forms of data collection: Firstly,
a retrospective chart evaluation of routine respiratory cultures 1.5
years before and after initiation of Trikafta. Respiratory culture
density was recorded based upon the growth fraction of standard
respiratory plate: none (0/4), scant (1/4), light (2/4), moderate (3/4),
and large (4/4). The second data measurement included obtaining
next-generation sequencing (NGS) for bacterial and fungal abundance of
post-Trikafta initiation patients only. Results There was a significant
density decrease in P. aeruginosa (1.5 vs 1.19, p= 0.01),
S. aureus (2.47 vs 1.9, p= 0.002), A. denitrificans (1.39
vs,1.14, p=0.02), E. coli (1.09 vs 1.00, p=0.045) before and
after initiation of Trikafta. On the NGS the 5 most abundant bacteria
after Trikafta initiation were : S. salivarius, S.
parasanguinis, R. mucilaginosa, V. atypica, and P.
histocola. Conclusion Our study results demonstrate that there is a
significant decrease in the density of known CF pathogenic bacteria. NGS
post-Trikafta has shown abundance of anaerobic bacteria ( S.
salivarius, S. parasanguinis, R. mucilaginosa, V.
atypica, and P. histocola) that have been linked to improved
clinical lung stability, lower airway inflammation and increased
polymicrobial diversity.
The spatial modeling of urban expansion. Case study Msila
Authors: Bediar Adel , Khalfalleh Boudjamea , Dehimi Salim
Published: August 2022

Understanding, analysis, monitoring and modelling of urban growth evolution
as a major driving force of land use, especially in developed countries, is
of great importance for land managers in the process of development. This
research aims to analyse the spatial modelling of urban expansion using
modern technologies - Delphi and Analytic Hierarchy Process (D-AHP) hybrid
model and Geographic Information System (GIS) technique for Land-Use
Assessment. These techniques are used to detect the most suitable and
unsuitable areas in the Msila zone. By engaging residents and experts to
choose criteria for analysing urban expansion, the study showed that 80.75%
of total area represent suitable lands for expansion and around 19%
represent unsuitable lands. By reading the results of the study, it is clear
that the total suitable lands are located in the southwestern side of the
city.
The Impact of the COVID-19 Pandemic on Ethnic Minority Groups With Diabetes
Authors: Khunti Kamlesh , Feldman Eva L. , Laiteerapong Neda , Parker William , Routen Ash , Peek Monica
Published: August 2022

Major ethnic disparities in diabetes care, especially for intermediate outcomes and diabetes complications, were evident prior to the coronavirus disease 2019 (COVID-19) pandemic. Diabetes is a risk factor for severe COVID-19, and the combination of these ethnic disparities in diabetes care and outcomes may have contributed to the inequity in COVID-19 outcomes for people with diabetes. Overall, ethnic minority populations have suffered disproportionate rates of COVID-19 hospitalization and mortality. Results from the limited number of studies of COVID-19 in ethnic minority populations with diabetes are mixed, but there is some suggestion that rates of hospitalization and mortality are higher than those of White populations. Reasons for the higher incidence and severity of COVID-19–related outcomes in minority ethnic groups are complex and have been shown to be due to differences in comorbid conditions (e.g., diabetes), exposure risk (e.g., overcrowded living conditions or essential worker jobs), and access to treatment (e.g., health insurance status and access to tertiary care medical centers), which all relate to long-standing structural inequities that vary by ethnicity. While guidelines and approaches for diabetes self-management and outpatient and inpatient care during the pandemic have been published, few have recommended addressing wider structural issues. As we now plan for the recovery and improved surveillance and risk factor management, it is imperative that primary and specialist care services urgently address the disproportionate impact the pandemic has had on ethnic minority groups. This should include a focus on the larger structural barriers in society that put ethnic minorities with diabetes at potentially greater risk for poor COVID-19 outcomes.
Sosyal Medyada Gerçek Zamanlı Pazarlama: Turizm Endüstrisinde Yer Alan İşletmelerin Sosyal Medya Paylaşımları Üzerine Bir İnceleme
Authors: Unurlu Çiğdem
Published: August 2022

Dijitalleşme ve teknolojik ilerlemeler, tüketicinin tüketim davranışını ve işletmelerin iş yapış biçimlerini kökten değiştirmiştir. Değişime adapte olabilen işletmeler geleneksel pazarlama uygulamalarından dijital pazarlama uygulamalarına hızlı bir geçiş yaparak gerçek zamanlı pazarlama uygulamaları ile tüketicileriyle güçlü bağlar kurmuşlar ve böylece rekabet avantajı elde etmişlerdir. Bu bakımdan bu çalışma esprili, doğal, yaratıcı, özgün ve samimi bir pazarlama yöntemi olan gerçek zamanlı pazarlama stratejisi ile tüketicinin gündeminde olmanın önemine işaret etmektedir. Bu noktadan hareketle çalışmada öncelikle gerçek zamanlı pazarlama stratejisi teorik olarak değerlendirilmiştir, sonrasında ise sosyal medyada gerçek zamanlı pazarlama süreçleri ele alınmış ve turizm endüstrisinde yer alan (oteller, hava yolu işletmeleri, yiyecek-içecek işletmeleri, eğlence merkezleri, rekreasyon tesisleri vb.) işletmelerin sosyal medyadaki güncel gerçek zamanlı pazarlama uygulamalarına yer verilmiştir. Nitel bir çalışma olarak planlanan bu çalışmada ikincil veriler kullanılmış ve turizm endüstrisinde yer alan işletmelerin sosyal medyada gerçek zamanlı pazarlama paylaşımları incelenmiştir. Bu paylaşımların hangi stratejik amaçla kullanıldığı; paylaşımlardaki içerik öğelerinin neler olduğu, kullanılan yazılı ve görsel unsurların nitelikleri ve gündem ile paylaşımlar arasındaki uyum değerlendirilmiştir.
Covid-19 Salgınının Konaklama ve Yiyecek-İçecek İşletmelerinin Finansal Performansına Etkisinin Ölçek Temelinde Analizi
Authors: Karadeniz Erdinç , İskenderoğlu Ömer , Helvacı İlter
Published: August 2022

Bu araştırmanın amacı, Covid-19 salgınının Türkiye’deki konaklama ve yiyecek-içecek işletmelerinin finansal performansı üzerindeki etkisini ölçek temelinde analiz etmektir. Bu amaçla Türkiye Cumhuriyet Merkez Bankası tarafından yayımlanan 2019 ve 2020 yıllarına ait konaklama ile yiyecek-içecek hizmetleri sektör bilançoları üzerinde oran analizi gerçekleştirilmiştir. Analiz sonucunda likidite açısından Covid-19 salgınının başlamasıyla işletmelerin performansının ölçek bazında önemli değişkenlik göstermediği belirlenmiştir. Finansal yapı oranları açısından Covid-19 salgınının başlamasından sonra işletmelerde daha fazla uzun vadeli yabancı kaynak kullanıldığı belirlenmiştir. Faaliyet ve karlılık oranları açısından ise Covid-19 salgınının başlamasıyla konaklama ile yiyecek-içecek işletmelerinin ölçek büyüklükleri fark etmeksizin tamamında performansın önemli düzeyde düştüğü saptanmıştır.
Restoranlarda Yiyecek İsrafının Belirleyicileri, Kaynakları ve Çıktılarına İlişkin Kavramsal Bir Model Önerisi
Authors: Yılmaz Gökhan , Çırak Kerem
Published: August 2022

Bu çalışma, turizm bağlamında restoran işletmelerinde arz ve talep kaynaklı ortaya çıkan yiyecek israfının değerlendirilmesini ve kavramsal bir model sunulmasını amaçlamaktadır. Önerilen model doğrultusunda restoran işletmelerinde yiyecek israfını belirleyiciler, kaynaklar ve çıktılar olmak üzere birbiriyle ilişkili üç süreçte ele almak mümkündür. Restoran türü ve servis şekli, yiyecek israfının belirleyicilerini oluştururken; üretim öncesi (satın alma, depolama gibi), esnası (yiyecek, fiziksel çevre gibi) ve sonrası (müşteri türü, profili gibi) aşamalarda yer alan unsurlar kaynakları meydana getirmektedir. Aynı zamanda modele göre yiyecek israfı birtakım çevresel, finansal ve sosyal çıktılara yol açmaktadır. Çalışma turizm bağlamında yiyecek israfını söz konusu faktörler üzerinden kavramsallaştıran ilk çalışmalardan biri olma özelliği taşımaktadır. Çalışmada araştırmacılar ve uygulamacılara yönelik öneriler de sunulmaktadır.
CLINICAL CASE OF CORONAVIRUS DISEASE COMBINED WITH INFECTIOUS MONONUCLEOSIS IN CHILDREN
Authors: Melnychuk L.
Published: August 2022

The article presents a clinical case of coronavirus disease in a child, combined in time with infectious mononucleosis. Today there is a growing tendency in the prevalence of diseases caused by herpes viruses. At the same time there is an increase in the incidence of infectious mononucleosis. The level of Epstein-Barr virus infection among the adult population of Ukraine has reached almost 100%, and more than 50% among the children. The number of children confirmed by COVID-19 is growing with each passing wave, and coronavirus disease is dangerous for young children with a high probability of complications and hospitalizations. The first manifestations of the disease were not typical: fever, nausea, periorbital edema. A week later, typical mononucleosis complaints of sore throat, "nasality", raids on the tonsils and enlargement of the tonsils appeared. Additional examinations revealed an increase in ALT and AST, an increase in the liver. The diagnosis was made on the basis of detecting an increase in the level of specific immunoglobulins to SARS-Cov-2 and EBV. The coronavirus disease can initiate the manifestation of persistent viruses, in particular EBV
CC16 ROLE IN BRONCHIOLITIS IN YOUNG CHILDREN
Authors: Tokarchuk N. , Overchuk A.
Published: August 2022

Introduction. CC16 protein is secreted by Club epithelial cells of the bronchioles, maintains homeostasis of theairway epithelium and has anti-inflammatory effects in the lungs. It is important to study the level of CC16 proteinin the serum in order to understand the integrity of the bronchial epithelium and the development of bronchialdysfunction in young children with bronchiolitis.Aim of the study. Analysis of blood serum CC16 concentration in younger bronchiolitis patients.Material and methods. We clinically examined 70 young children. The main group consisted of 35 non-allergicbronchiolitis patients. The comparison group included 25 young bronchiolitis patients with a history of allergies.The control group comprised 10 conditionally healthy children. The average age of patients was 8.4 ± 1.6 months,6.2 ± 1.4, and 6.4 ± 1.2 months in the main, comparison, and control group, accordingly. The complex of clinicaland-laboratory examination of children included CC16 serum tests. Serum CC16 content was determined by enzymelinked immunosorbent assay according to the “Human CC16 ELISA Kit”.Results of the study. It should be noted that the most main group patients (22 (62.8 ± 6.4%) of all examined) hadelevated CC16 readings. Whereas in the comparison group we did not find an increase in CC16 protein in any case.In contrast, 13 (51.8 ± 14.4%) children with bronchiolitis with a history of allergy had a decrease in CC16 protein,which may be a sign of endothelial dysfunction (p = 0.01).The study showed that young non-allergic bronchiolitis patients had the mean CC16 (38.9 ± 4.5 ng/ml) significantlyhigher than those with a history of allergies (22.9 ± 3.3 ng/ml), (OR=1,667; 0,854 - 3,250 95% CI; p < 0,05). Thecontrol group patients had the mean CC16 within the reference interval (14.2 ± 2.12 ng/ml).Conclusions. In young children, elevated CC16 may be considered a marker of respiratory failure in bronchiolitispatients. Bronchiolitis patients with a history of allergies had statistically significantly lower serum CC16 levels thanthose in children without a history of allergies.
CHANGES IN MARKERS OF ENDOTHELIAL FUNCTION, LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION IN PREGNANT WOMEN WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Oleksyak O. , Heriak S.
Published: August 2022

Introduction. Increasing prevalence of chronic obstructive pulmonary diseases (COPD) in the female populationrequires timely diagnosis of COPD in pregnant women. Changes in markers of lipid peroxidation and antioxidantprotection, which eventually lead to endothelial dysfunction, play a prominent role in pathophysiology of COPDdisorders. During pregnancy, these changes cause obstetric and perinatal complications.The aim of our study was to determine the effect of markers of endothelial dysfunction, lipid peroxidation andantioxidant protection on the development of obstetric and perinatal complications in pregnant women with chronicobstructive pulmonary disease of different severity.Materials and methods. Fifty-six pregnant women with clinically and instrumentally verified signs of COPDwere examined. The main group of pregnant women was divided into the IA subgroup (29 women with mild bronchialobstruction) and the IB subgroup (27 women with moderate bronchial obstruction). The control group consisted of 24healthy pregnant women. The function of biochemical markers of endothelial function (endothelin-1 and circulatingdesquamated endotheliocytes) and the activity of lipid peroxidation and antioxidant protection (malondialdehyde,diene conjugates, superoxide dismutase) were assessed in all groups of women. The incidence of obstetric andperinatal complications in the examined groups of pregnant women with COPD was determined.Results and discussion. In pregnant women with signs of COPD there was a pronounced tendency for the levels ofintermediate products of lipid peroxidation to increase (malondialdehyde was 22.6% higher in the IA subgroup and52.9% higher in the IB subgroup, The study group showed a marked tendency toward an increase in the levels of lipidperoxidation intermediates (malondialdehyde increased in the IA and IS subgroups by 22.6% and 21.9%, respectively,compared with controls) and a decrease in the enzymatic activity of the antioxidant protection system (superoxidedismutase decreased by 15.9% and 21.2% in the IA and IB subgroups, respectively, compared with controls).As a result of the imbalance in the LPO/AOP system and the development of endothelial dysfunction, we observedan increase in the development of obstetric and perinatal complications in pregnant women of the main group whohad COPD. Anemia (41.4% in the IA and 63.2% in the IB subgroup), placental dysfunction (51.7% in the IA and66.6% in the IB subgroup), preterm birth threat (13.8% and 25.9%, respectively), and fetal growth retardationsyndrome (13.8% and 22.2%, respectively) were more common.Conclusions. Pregnant women with COPD have abnormalities in basic markers of endothelial function, lipid peroxidationand antioxidant protection, which are accompanied by an increased incidence of obstetric and perinatal complications andrequire the development of adequate treatment and prophylaxis programs in pregnant women with COPD.
Performance Assessment of Diffusive Load Balancing for Distributed Particle Advection
Authors: Demiralp Ali Can , Helmrich Dirk Norbert , Protze Joachim , Kuhlen Torsten Wolfgang , Gerrits Tim
Published: August 2022

Particle advection is the approach for extraction of integral curves from vector fields. Efficient parallelization of particle advection is a challenging task due to the problem of load imbalance, in which processes are assigned unequal workloads, causing some of them to idle as the others are performing compute. Various approaches to load balancing exist, yet they all involve trade-offs such as increased inter-process communication, or the need for central control structures. In this work, we present two local load balancing methods for particle advection based on the family of diffusive load balancing. Each process has access to the blocks of its neighboring processes, which enables dynamic sharing of the particles based on a metric defined by the workload of the neighborhood. The approaches are assessed in terms of strong and weak scaling as well as load imbalance. We show that the methods reduce the total run-time of advection and are promising with regard to scaling as they operate locally on isolated process neighborhoods.
Fitting Parameters for Procedural Plant Generation
Authors: Garifullin Albert , Shcherbakov Alexandr , Frolov Vladimir
Published: August 2022

We propose a novel method to obtain a 3D model of a tree based on a single input image by fitting parameters for some procedural plant generator. Unlike other methods, our approach can work with any plant generator, treating it as a black-box function. It is also possible to specify the desired characteristics of the plant, such as the geometric complexity of the model or its size. We propose a similarity function between the given image and generated model, that better catches the significant differences between tree shapes. To find the appropriate parameter set, we use a specific variant of a genetic algorithm designed for this purpose to maximize similarity function. This approach can greatly simplify the artist's work. We demonstrate the results of our algorithm with several procedural generators, from a very simple to a fairly advanced one.
Development of a Multi-spectral Camera for Computer vision applications
Authors: Mohammadi Vahid , Sodjinou Sovi Guillaume , Katakpe Kossi Kuma , Rossé Matthieu , Gouton Pierre
Published: August 2022

The need to multispectral cameras is growing in different fields. The goal is to provide inexpensive, flexible, or high resolution acquisition set-ups for different applications. Production of cheap and easy-to-use multispectral cameras requires the design and development of specific multispectral camera sensors equipped with multispectral filter arrays. Filter arrays, band width, and spectral response of filters should be analyzed and determined before mounting the filters on the image sensor. In this study, a multispectral camera sensor was designed to be used for computer vision applications (e.g. crop/weed detection, fruit ripeness estimation etc.) covering visible range. The developed camera sensor is consisted of the image sensor, spectral filter array, a sensor board, and a driving board. A hybrid system is proposed that works using eight bands in visible range (i.e. 400-700 nm). A program was developed based on Genetic Algorithm to find the best combination of filters. The program selects the Gaussian filters using a genetic algorithm powered by wiener filter estimation method. For the selection of bands, minimum RMS of 0.0016 was obtained for the selected bands in visible. The developed camera provides eight high resolution spectral images.
Mip-NeRF RGB-D: Depth Assisted Fast Neural Radiance Fields
Authors: Dey Arnab , Ahmine Yassine , Comport Andrew I.
Published: August 2022

Neural scene representations, such as Neural Radiance Fields (NeRF), are based on training a multilayer perceptron (MLP) using a set of color images with known poses. An increasing number of devices now produce RGB-D(color + depth) information, which has been shown to be very important for a wide range of tasks. Therefore, the aim of this paper is to investigate what improvements can be made to these promising implicit representations by incorporating depth information with the color images. In particular, the recently proposed Mip-NeRF approach, which uses conical frustums instead of rays for volume rendering, allows one to account for the varying area of a pixel with distance from the camera center. The proposed method additionally models depth uncertainty. This allows to address major limitations of NeRF-based approaches including improving the accuracy of geometry, reduced artifacts, faster training time, and shortened prediction time. Experiments are performed on well-known benchmark scenes, and comparisons show improved accuracy in scene geometry and photometric reconstruction, while reducing the training time by 3 - 5 times.
ON THE PECULIARITIES OF THE ENGLISH PENITENTIARY DISCOURSE RENDERING IN UKRAINIAN TRANSLATION
Authors: Derik Ilona
Published: August 2022

The article is devoted to the study of the peculiarities of the English penitentiary discourse rendering in Ukrainian translation. The urgency of the work is due to the urgent need for a comprehensive study of penitentiary texts. The objective of the research is to outline the peculiarities of penitentiary discourse, the study of different approaches to the interpretation of this phenomenon and the formulation of the key rules of translating English penitentiary discourse into Ukrainian. This resulted in the following tasks: to clear out the notion of discourse in linguistics and its specificity; to characterize the structural features of penitentiary discourse; to study the peculiarities of terms in penitentiary discourse and to analyze translation transformations employed in rendering English penitentiary discourse in Ukrainian.The comprehensive approach to the research allowed to enlarge and extend the scope of the terminological lexes, to reveal the linguistic means of penitentiary discourse realization as well as strategies, techniques and transformations employed in rendering English penitentiary texts in Ukrainian translation. As for the lexical transformations employed, their distribution may be characterized as follows. Loan translation was used in 25 cases or 12,5 %, transliteration in 22 cases or 11,0 %, lexico-semantic replacements in 69 cases or 34,5 %, concretization in 27 cases or 13,5 %, generalization in 16 cases or 7,0 %, modulation in 23 cases or 11,5 %. As for the grammatical transformations employed, their distribution may be characterized as follows. Grammatical replacements occur in 9 cases or 4,5 %, transpositions in 8 cases or 4,0 %, the null translation or omission in 3 units or 1,5 %. The practical value of the article and its efficiency may be grounded by a great demand for the qualified study of such issues as the speech of legislation and execution. The perspective may be seen in the compilation of a thesaurus or glossary of penitentiary terms.
Hermeneutik der Entfremdung. Sprache und Verstehen im Spannungsfeld von Fremd- und Selbstbestimmung
Authors: Rüegger Hans-Ulrich
Published: August 2022

Die Begriffe Fremdbestimmung und Entfremdung sind gewöhnlich negativ konnotiert. Insofern der Mensch ein sprechendes und verstehendes Lebewesen ist, gehören jedoch Momente der Fremdbestimmung und der Entfremdung unabdingbar zum Menschsein. Eine Sprache zu lernen und etwas zu verstehen, sind Grundmomente menschlicher Bildung. Sie bedingen, sich auf etwas Fremdes einzulassen und sich mehr oder weniger von diesem Fremden auch bestimmen zu lassen.
How cloud accounting and integrated services based on AI can impact accounting companies?
Authors: Mihai Mirela Simina , Duţescu Adriana
Published: August 2022

Artificial intelligence solutions are not present only in big companies, but the new trend is to start changing the accounting profession also in small and medium companies. In order to shorten the period in which they will have access to artificial intelligence solutions, the artificial intelligence needs to be offered in a more accessible form. This paper represents the first step in a more in depth research about the way available resources for an organization to implement artificial intelligence solutions in their financial departments. This decision has the potential to bring fundamental changes to accounting and auditing, and in the entire financial markets. This paper explores the potential of artificial solutions adaptation in accounting, identifying the steps already taken in this field of activity which will help them to implement further changes. We investigate mainly the organizational changes brought by cloud computing and its potential for the accounting field to adapt to further technological solutions. We assessed the cloud computing’s effect on the accounting profession, and the potential role of these professions in further implementing more intelligent solutions, as well as the main advantages and disadvantages in order to understand the reasons for high interest in migration to cloud computing, especially during the COVID-19 crisis.
Persepsi Guru SMA Terhadap Ujian Nasional SD/MI
Authors: Safari Safari
Published: August 2022

Tujuan penelitian ini adalah untuk menjawab beberapa permasalahan: (1) Setujukah diadakan Ujian Nasional (UN) SD/MI? (2) Apakah terdapat perbedaan persepsi guru mata pelajaran SMA terhadap: (a) motivasi belajar siswa terhadap materi, (b) kemampuan akademik siswa, (c) keinginan melanjutkan ke SMP/MTs, (d) akhlak siswa, (e) keobjektifan guru dalam memberi skor/nilai ujian, (f) kemampuan guru menulis soal; selama tidak ada UN. Berdasarkan analisis deskriptif dan uji Chi-Square dari 257 responden/guru mata pelajaran diperoleh hasil sebagai berikut. Pertama, sebagian besar 145 responden (56,4%) guru mata pelajaran SMA menyatakan setuju diadakannya UN SD/MI dan hanya 101 responden (39,3%) yang menyatakan tidak setuju, serta 11 responden (4,3%) responden yang tidak menjawab. Kedua, pelaksanaan ujian SD/MI selama belum adapengganti UN, sebagian besar guru mata pelajaran SMA menyatakan “sedang” pada keenam aspek: (1) motivasi belajar siswa, (2) kemampuan akademik siswa, (3) keinginan siswa SD/MI melanjutkan ke SMP/MTs, (4) akhlak siswa, (5) guru objektif dalam memberi skor/nilai ujian, (6) kemampuan guru menulis soal. Hal ini menunjukkan adanya indikasi perbedaan persepsi guru mata pelajaran terhadap pelaksanaan ujian SD/MI selama tidak ada pengganti UN adalah tidak terbukti (P>0,05).
Daya Responsif Arsitektur Karo Terhadap Adaptasi Perilaku New Normal
Authors: Lindarto Dwi , Pratikno Priyo , Koesmartadi Christophorus
Published: August 2022

Era new normal adalah kebiasaan dalam beradaptasi dengan pandemi Covid-19. Ini terwujud dalam kegiatan sosial masyarakat utamanya menjaga jarak sosial dan tidak berkerumun. Perilaku demikian menuntut ruang arsitektur yang responsif. Arsitektur Karo sebagai wujud kearifan lokal masyarakat teruji dalam menghadapi pandemi lepra di era 1920an. Riset ini bertujuan mengungkap jejak transformasi dan adaptasi arsitektur Karo dalam merespon pandemi lepra di masa lampau yang memiliki dampak yang dipandang setara dengan pandemi Covid-19. Ini merupakan studi dengan pendekatan kualitatif yang menerapkan arsitektur perilaku mengkaji perilaku teritorial dan personal space saat pesta adat Karo yang dilaksanakan di Jambur. Dengan koridor elemen arsitektur Gottfried Semper maka jejak transformatif Jambur Karo lalu dianalisis dengan metode interpretasi Ricoueur dan kritik interpretatif  Wayne O Attoe. Melalui validasi yang dilandasi pemikiran fantasia Lacanian diperoleh hasil bahwa tata ruangan tanpa sekat dinding masif, konstruksi, teritorial kekerabatan, fasilitas outdoor dan ornamentasi pada arsitektur Si Waluh Jabu dan Jambur Karo merupakan unsur yang responsif terhadap perilaku new normal. Hasil pengetahuan indigenous ini merupakan alternatif pemikiran konsep arsitektur berbasis kearifan lokal arsitektur Nusantara menghadapi masa pandemi Covid-19.Kata kunci: arsitektur karo; arsitektur perilaku; new normal era; personal space; teritorial
Analisis Desain Kantor Post-Pandemi Covid-19 di DKI Jakarta
Authors: Tarigan Surya Gunanta , Mannan Khalid Abdul
Published: August 2022

Salah satu dampak pandemi Covid-19 adalah mengubah cara kita bekerja dan bagaimana kita mendefinisikan ‘tempat kerja‘ yang selama ini identik dengan kantor. Selama masa pandemi hampir semua perusahaan menerapkan work from home (WFH) yang pada akhirnya membuat perusahaan harus mendefinisikan kembali arti penting kantor bagi perusahaan. Implikasi dari masalah ini adalah kantor harus bisa beradaptasi terhadap fungsi baru yang kemungkinan besar akan berubah. Tujuan penelitian yaitu menganalisa perubahan kantor sebagai tempat bekerja dan bagaimana desain kantor beradaptasi dengan perubahan kebutuhan akan tempat kerja post-pandemi Covid-19. Penelitian dilakukan dengan metode kualitatif eksploratif dimana interview dilakukan dengan profesional dari biro arsitektur maupun interior yang merancang perkantoran di DKI Jakarta. Kemungkinan kantor kedepannya lebih dipandang sebagai tempat membangun budaya perusahaan, tempat melakukan pelatihan dan training, tempat bersosialisasi karyawan serta menjamu klien dan mengundang talent potensial. Study ini juga mendiskusikan bagaimana konsep kantor hybrid dapat menjadi solusi ke depannya.Kata kunci: desain kantor; ruang kerja; Jakarta; pandemi Covid-19
Collagen Peptide Combined with Annona Muricata Fermentation, Snow Lotus and Rosa Rugosa Improve Skin Condition and Anti-Inflammation
Authors:   Research & Design Center, Chiang Chi-Fu
Published: August 2022

Skin aging is a complex and continuous process that affects skin functions and appearance
The Impact of Daily Walnuts Consumption and Lifestyle Changes on Dyslipidemia
Authors:   Sri Devaraj Urs Academy, CS Shivakumara
Published: August 2022

The most frequent health condition linked to Cardiovascular Disease Is Dyslipidemia (CVD)
Barreras Invisibles. Jóvenes, pobreza y violencia
Authors: Castillo Valencia María , Jiménez Restrepo Diana Marcela , Franco Calderón Ángela María , Salazar Trujillo Boris , Caicedo Hurtado María Isabel
Published: August 2022

Barreras Invisibles. Jóvenes, pobreza y violencia aborda la exclusión laboral, social y racial a través del lente de las características socioeconómicas, formas de vida, redes y entorno de personas jóvenes ex integrantes de pandillas en la ciudad de Cali, Colombia. Estas personas habitan en su mayoría en los barrios más pobres y marginados de la ciudad y enfrentan barreras que les dificultan el acceso a oportunidades de educación y trabajo que les permitan salir de la espiral descendente de la pobreza. Desde el momento en que nacen se repiten los patrones de vulnerabilidad heredados de sus progenitores quienes tampoco tuvieron acceso a unas mejores condiciones de vida. Como se presenta en los resultados de esta investigación, desarrollada por la Universidad del Valle con la financiación del Centro Internacional de Investigaciones para el Desarrollo (IDRC/CDRI) de Canadá y el acompañamiento de la Facultad Latinoamericana de Ciencias Sociales (FLACSO), Sede de Costa Rica, las personas jóvenes de estos sectores crecen no sólo enfrentando carencias económicas, rechazo social y compitiendo por recursos escasos, sino en contextos de violencia que aumentan su riesgo de ser víctimas o de quedar atrapados en un círculo vicioso de actividades delictivas. Además de presentar una radiografía de la realidad actual, este libro incluye aprendizajes y recomendaciones sobre acciones de atención a la población joven a partir del trabajo directo con un grupo de beneficiarios del Programa Tratamiento Integral de Pandillas – Jóvenes sin Fronteras en Cali.
Generation z's perceptions of health information about the Covid-19
Authors: Nursanti Siti , Dharta Firdaus Yuni , Chaerudin Chaerudin , Syam Syisea Putri , Purnama Rifki Nugraha
Published: August 2022

The COVID-19 pandemic has spread widely worldwide, and Indonesia is no exception. It has led the government to enforce an imperative policy, advising most activities to be done at home by everyone, including Generation Z, that has lived and grown up among the advances in communication and information technology. This study examines Generation Z's perceptions of health information regarding the COVID- 19 pandemic. This study was conducted utilising a quantitative research technique utilising a survey methodology. In this study, it was found that Generation Z firstly learned about the emergence of the COVID-19 virus on the internet, especially on social media. No negative perception was found from Generation Z related to any information shared on the internet, including their social media. Additionally, the study found that getting health information through social media was their choice, closely related to their daily activities.
2-propanol decomposition at the Co3O4 (001)/H2O Interface: Influence of Temperature, Surface Composition and Electrochemical Environment
Authors: Kox Tim , Omranpoor Amir H. , Kenmoe Stephane , Spohr Eckhard
Published: August 2022

Ab initio molecular dynamics simulations of a single hydrated 2-propanol molecule were performed to study the role of temperature, surface structure and electrochemical environment for the oxidation of 2-propanol to acetone at the Co3 O4 (001)/H2 O interface. On the A-terminated and B-terminated surfaces, which differ in the relative number of Co2+ and Co3+ ions at the surface, 2-propanol adsorbs molecularly on the Co2+ and Co3+ sites, respectively. In both cases, no C-H bond cleavage is observed at room temperature. However, under oxidative conditions, which are modeled here by partial dehydrogenation of the mixed hydroxyl/water adsorbate layer, dehydrogenation of the alcoholic OH group is observed on both surface terminations. As a result, adsorbed 2-propanolate is formed. The reaction on the less hydroxylated B- terminated surface further proceeds with C-H bond cleavage at the 2-carbon atom. The oxidation product acetone remains adsorbed on the Co3+ site during the simulation period of approximately 20 ps. Both deprotonation steps are aided by the presence of the adsorbed hydroxyl groups in the vicinity of the adsorbed alcohol molecule, because both hydrogen atoms from the reac- tand molecule are transferred as protons to form adsorbed water molecules. Different from the case of the partially dehydrogenated environment, raising the system temperature from 300 to 450 K, which can be considered a simple model for high temperature thermal catalysis, does not lead to oxidation via C-H dehydrogenation of the 2-propanol molecule.
Perturbative expansion of non-orthogonal product approach for charge-transfer states
Authors: Glebov Ilya , Poddubnyy Vladimir , Khokhlov Daniil
Published: August 2022

Modeling of the excited states of multichromophoric systems is crucial for the understanding of photosynthesis functioning. The excitonic Hamiltonian method is widely used for such calculations. Excited states of the combined system are constructed from the wave functions of individual chromophores while their interactions are described by excitonic couplings. In the current study we enhance earlier proposed non-orthogonal product approach to incorporate dynamic correlation effects accounted for by the multireference perturbation theory. We discuss the problems of constructing the excitonic Hamiltonian including charge-transfer states for the molecular systems where the overlap contribution to the excitonic couplings is non-negligible. The benchmark calculations were performed for a model system. It was shown that the overlap component of the excitonic coupling is of great importance. The enhanced method provides an accurate description of the excited states energies and other properties.
The Performance of Different Water Models on the Structure and Function of Cytochrome P450 Enzymes
Authors: Yadav Shalini , Kardam Vandana , Tripathi Ankita , T G Shruti , Dubey Kshatresh
Published: August 2022

Modelling approaches and modern simulations to investigate the biomolecular structure and function rely on various methods, one among which is the choice of the water model. Water molecules play a crucial role in all sorts of chemistry. Cytochrome P450 (CYP450), in particular, water molecules are crucial for the formation of active oxidants which perform the oxidation and metabolism of several substrates. Computational chemistry tools such as MD simulations and QM/MM calculations, nowadays, have become complementary tools to study the structure and functions of CYP450 enzymes, and therefore, accurate modeling of water molecules is crucial. In the present study, we have highlighted the behavior of the three most widely used water models—TIP3P, SPC/E, and OPC for three different CYP450 enzymes—CYP450BM3, CYP450OleT, and CYP450BSβ during MD simulations and QM/MM calculations. We studied the various properties such as RMSD, RMSF, H-bond, water occupancy in the first solvation shell, and Hydrogen Atom Transfer (HAT) using QM/MM calculations and compared them for all the three water models. Our study shows that the stability of the enzyme structure is well maintained in all three water models. However, OPC water model performs well for the polar active sites, i.e., in CYP450OleT, CYP450BSβ while the TIP3P water model is superior for the hydrophobic site such as CYP450BM3.
Algebraic properties of the Choquet integral
Authors: Броневич Андрей Георгиевич , Розенберг Игорь Наумович
Published: August 2022

В данной работе рассматриваются свойства интеграла Шоке в зависимости от монотонной меры, относительно которой производится интегрирование, а именно, от ее принадлежности к семействам монотонных мер, рассматриваемых в теории неточных вероятностей. В частности, рассматривается порождение монотонных мер с помощью интеграла Шоке, а также порождение монотонных мер на алгебре нечетких множеств. Приводится также новый подход аксиоматизации интеграла Шоке, основанного на каноническом представлении простых функций.

In the paper, we analyze how the properties of the Choquet integral depend on a monotone measure, which are used in integration, namely, based on its characterization in the theory of imprecise probabilities. In particular, using integration, we can generate monotone measures and characterize them by identifying their membership to various families of lower and upper probabilities. In addition, with the help of the Choquet integral, we generate monotone measures on the algebra of fuzzy subsets and analyze their properties. In the paper, we also present a new approach of the Choquet integral axiomatization based on the canonical representation of simple functions.
Crayons in the Courtroom: Jurors’ Beliefs about Children’s Drawings and their Impact on Child Witness Credibility
Authors:   , Curtis Ashlee
Published: August 2022

In cases of child maltreatment, the child is often the sole eyewitness to the event. This means it is important that a child’s testimony of the event is detailed, specific, and accurate (Salmon et al., 2012). To help elicit these testimonies, interviewers may ask children to “draw what happened to them”. These drawings then become an evidential exhibit presented to jury members in court (Cohen-Liebman, 2013). The presentation of drawings alongside a child’s testimony may impact how competent and trustworthy a child witness is perceived to be (Danby et al., 2021). Across two studies, the current research explored the beliefs that jury members hold about children’s drawings and the impact that these beliefs may have on the evaluation of a child’s testimony. Within the first study, potential jurors (N=503) completed an online survey exploring their beliefs about the use of drawings within forensic settings. Drawings were generally thought to be highly beneficial and allow access into a child’s cognitive world; however, participants also identified some risks associated with having children draw. The second study investigated whether the presence of a child’s drawing alongside their testimony influenced how the child witness was perceived. Within this study, potential jurors (N=502) read a simulated transcript of a child reporting a traffic incident and rated the child witness’ credibility. Within each transcript, the child’s age (6 or 10- years-old) and the drawing they presented (no drawing, low-quality drawing, or high-quality drawing) were manipulated. All findings indicated that the child’s age and the presence of a drawing had no significant influence on child credibility ratings. Collectively, these studies suggest that although jurors hold strong beliefs about the meaning within children’s drawings, these beliefs may not always influence jurors’ evaluation of a child witness. However, further research is required to comprehensively understand the conditions in which drawings may be a highly compelling and influential form of evidence.
One Big Front Yard
Authors:   , Parbhu Bhakti
Published: August 2022

Coastlines have seen a shift in natural behavior in the past few years. Roughly a quarter of the world’s population reside nearby or on our current coastlines. Not only are the coastlines at risk but even more so each individual neighbourhood and the sense of belonging within them are at risk.

Action has begun to be taken against climate change across many countries. Different coasts are at risk from different threats and different levels of danger. Common approaches have been used depending on how vulnerable a place is. Managed retreat is becoming an approach where people and neighbourhoods are moved further inland in order to be protected by the shifting seas. This allows a safe buffer between the sea and infrastructure while also maximizing the public space in-between.

Lyall Bay is the focal case study for this research. The threatened beachfront and locals along create an opportunity to bridge the gap between resiliency against the shifting seas and preserving the local sense of belonging. Lyall Bay is known for it public space along the beachfront becoming a significant part of peoples sense of belonging within it. Managed retreat can become a strategy to transform the private space into a larger public space by removing hard infrastructure that is at risk while also allowing natural processes to occur leading to enhancing the sociability within it.

This research undergoes an analysis on the existing social, physical and ecological structures and how these form and allow for a feeling of belonging for the locals. This project aims to enhance the existing ecological systems, preserve the sense of belonging and create a more resilient retreat for a longer lasting suburb.

This research has to lead to an assemblage of findings that allow people to feel a sense of belonging within Lyall Bay. The beachfront is the main area where it becomes a place for everyone. It allows space for a variety of activities catering to a large number of different people. The design aims to preserve while also protecting the site ecologically by giving room for the dune systems to expand. It also provides safer housing opportunity that is situated over a buffer zone away from risks such as storm surge which Lyall Bay has experienced more frequently the past few years. The housing allows for a larger number of residents on site while creating retail opportunities through mixed use buildings. The design allows for a larger public space in between the sea and the residential space maximizing the sociability in between.
Pengaruh Media Apron Hitung Untuk Meningkatkan Kemampuan Berhitung Anak Kelompok B TK Pertiwi II Sossok
Authors: Alfitri Nurma , Saodi Syamsuardi , Herman Herman
Published: August 2022

Tujuan penelitian ini adalah untuk mengetahui gambaran kemampuan berhitung anak sebelum dan setelah diberi perlakuan media Apron Hitung, dan untuk mengetahui ada tidaknya pengaruh media Apron Hitung terhadap kemampuan berhitung anak kelompok B di TK Pertiwi II Sossok. Dengan menggunakan pendekatan kuantitatif dengan jenis penelitian Quasi Ekperiment Design. Subjek dalam penelitian ini adalah kelompok B di TK Pertiwi II Sossok yang berjumlah 12 anak. Berdasarkan hasil pengkajian hipotesis diperoleh nilai Thitung 7 > Ttabel 2,228 dan nilai Zhitung 0,735 > Ztabel 0,2734, artinya terdapat pengaruh variabel media Apron Hitung terhadap kemampuan berhitung anak kelompok B TK Pertiwi II Sossok.
Non-compliance to SAP on local governments in Indonesia: The impact of internal control weaknesses in internal control in accounting and financial reporting and regional complexity
Authors: Muhtar Muhtar
Published: August 2022

This study attempts to analyze the impact of internal control weaknesses in accounting and financial reporting as well as local government complexity on the non-compliance with Government Accounting Standard (SAP) implementation in Indonesian local governments. Using secondary data from the audit results from the Supreme Audit Board (BPK) on Local Government Financial Reports (LKPD), this study finds that there are still non-compliance with SAP in a number of local governments in Indonesia since the application of accrual-based accounting was required in 2015. On the bright side, the number of non-compliance continues to decrease from year to year. Further, this study reveals that the weakness of internal control in accounting and financial reporting as well as regional complexity has a positive effect on non-compliance with SAP implementation. This research encourages local governments to evaluate and make improvements to the existing internal control weaknesses and accommodate the high complexity level through the development of adequate accounting competencies as well as effective and efficient accounting and financial reporting systems. Thus, local governments can produce LKPD that are compliant with SAP with more reliable and relevant financial information.
Do the saving interest in Islamic banks affected by financial literacy and religiosity?
Authors: Nursari Ayu , Atahau Apriani Dorkas Rambu , Sakti Imanuel Madea
Published: August 2022

This study examines the effect of financial literacy and religiosity on interest in saving at Islamic banks in the people of Tlogomulyo District, Temanggung Regency. This study uses a quantitative approach with the data used using primary data using an online questionnaire via a google form. The questionnaire was taken using the purposive sampling technique with the number of samples used in this study being 76 respondents. This research was conducted using the multiple regression analysis methods and tested using SPSS. The test results prove that religiosity has a positive effect on interest in saving in Islamic banks in the people of Tlogomulyo District, Temanggung Regency. While financial literacy does not affect the interest in saving in Islamic banks in the people of Tlogomulyo District, Temanggung Regency.
MULTIPLICATIVE APPROXIMATION METHOD OF FUNCTIONAL DEPENDENCIES BY LINE SEGMENTS
Authors: Khudaverdiyeva Mahabbat
Published: August 2022

The article is devoted to the approximation problems of functional dependencies during conversions performed in intelligent measurement devices. Non-linearities are essential parts of most control processes and systems. When using a nonlinear transmitter with a conversion function in measurement information systems used in various fields, it is necessary to perform nonlinear functional conversion operations on numbers in microprocessors/microcontrollers during direct and indirect measurements. For this purpose, various approximation methods are used. The purpose of the approximation is to describe nonlinear functions in a simpler, more convenient way for utilization and calculations, with an insignificantly small loss of accuracy. Existent methods for linearization, although some of them are effective, can be burdensome for implementation in microprocessor-based systems. Here, one of the proposed methods for the approximation of nonlinear functional dependencies by line segments is proposed. In this method, the range of the argument changes in the function is divided into line segments, and the parts of the coordinate system bisector, remaining within the line segments of the function, is swapped to perform approximation. Having involved few simple mathematical operations, the proposed method can be implemented efficiently in microprocessors/microcontrollers to perform approximations in measurement systems.