bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Teeth Replacement Options Among Partially Edentulous Libyan Patients In A Multi-clinic Center in Benghazi: A War-time Cross-Sectional Study
Authors: El huni Rabie
Published: December 2023

Introduction: What is the best replacement option for my compromised/missing tooth? The answer to this question, among our patients, varied considerably based on multiple factors including patient health and desire, prognosis of the natural teeth, service cost, dentist experience, availability and quality of the laboratory product, applicability of the offered option, and duration needed to finish the chosen job.Aim of the study: Is to determine the prevalence of selecting dental implants, among given teeth replacement options, by partially edentulous Libyan patients in a multi-clinic private center in Benghazi.Materials and Methods: This study was conducted at Sama Dental Center. All implant placement and restoration procedures were done by the same prosthodontist. Subjects were eligible for inclusion if they were partially edentulous and seeking definitive teeth replacement options. The study consisted of 170 patients (33 men and 137 women) ranging in age from 18 to 78 years.Results: A total number of 85 patients opted for dental implants (50%) (P. value 0.079) for whom 147 fixtures were integrated to replace 161 missing teeth. 56 of the patients chose removable partial dentures (32.9%), while fixed partial dentures were used to replace 31 missing teeth in 29 patients (17.1%) utilizing 47 natural abutments. Conclusion: Within the limitation of this study, there is an increasing interest in implant treatment option among partially edentulous Libyan Patients. Furthermore, evidence-based data may guide the dental practitioners’ confidence to offer the optimal treatment available to patients.
Calcifying Epithelial Odontogenic Tumor (Clear-Cell Variant) A case report and literature review
Authors: A. Hamouda Saleh , M. Musa Asma , ElHoni Ashour , M. Elmurtadi Ali
Published: December 2023

Calcifying epithelial odontogenic tumor (CEOT), or the Pindborg tumor, is very rare neoplasm, which accounts up to 1% of all odontogenic tumors. CEOT is locally aggressive benign odontogenic neoplasmarising from epithelial tissue. CEOT is rarely reported in Libya.Here in, we present an additional case of 55 year old female patient with a clear cell Variant (CCEOT) of CEOT located in the left posterior maxilla with maxillary sinus extension, with an emphasis on clinical, radiographic and histopathology features and review of literatures.
EVALUATION OF ANCHORAGE TECHNIQUE ON THE ADAPTION OF PARTIAL DENTURE FRAMEWORK (COMPARATIVE IN VITRO STUDY)
Authors: M Lefsaay Amel , H Elgtlawi Mohamed , E Burawi Gamal
Published: December 2023

The cast partial removable partial denture must be well fitted on the master dental cast and also on the oral tissues to be more successful and fulfill its functions. The objective of this in-vitro study was to evaluate the effect of anchorage on the accuracy of fit in removable partial denture framework. The study consisted of fourteen maxillary partially edentulous refractory casts Class III Kennedy classification modification 1which were divided equally into two groups group I test group (Anchorage technique) and group II control group (Conventional technique). Seven cobalt chrome removable partial denture frameworks were constructed for each group, one using conventional technique with performed wax pattern on a refractory casts and other seven cobalt chrome removable partial denture frameworks were constructed using anchorage technique including four holes for anchorage on the refractory casts. Both patterns were invested and casted under the same circumstances using conventional standardized technique.The resulting metallic removable partial denture frameworks were evaluated to check the fitness of palatal strap the major connector on the master metal cast using digital micrometer.The statistical results of this study showed significant reduction in the thickness (gap) between the palatal strap major connector and its related site among group I (Anchorage) when compared with group II(Conventional) which indicating more accurate fit for group I. Furthermore, all the frameworks which were constructed by anchorage technique revealed more gap reduction centrally and anteriorly than peripherally and posteriorly.
Pilomatrixoma of the Cheek: A Case Report
Authors: Elhoni Ashour , ElGehani Amna
Published: December 2023

Pilomatrixoma “Calcifying epithelioma of Malherbe” is a benign calcifying tumor that arises from the hair matrix. It is more common in females and usually presents during the first two decades of life as an asymptomatic, mobile, firm to hard mass. Most of the cases are benign and affect the face. Surprisingly, a preoperative diagnosis of pilomatrixoma is rarely considered by clinicians and often mistaken for other skin-based and subcutaneous lesions. We report a case of pilomatrixoma of the cheek in female Libyan patient, that was clinically diagnosed as a benign salivary gland tumor or reactive lymph node with histopathological findings, and a brief review of the literature. Molar root canal number in more than thirty studies and case reports published so far.
Awareness of the association between periodontal disease and adverse pregnancy outcome among the female population in Benghazi city-Libya
Authors: Werfully Salma Mahfoud , Al Ghazal Logien
Published: December 2023

Objectives: Chronic periodontitis is initiated and sustained by bacterial plaque, but host defence mechanism plays an integral role in it is pathogenesis. Periodontal disease (PD) is affecting more than 23% of women between the age of 30 and 54 years. Female sex hormones – progesterone and estrogen- vary in their levels throughout a women’s life, depending on which phase she is at (Puberty, Pregnancy or menopause). Progesterone has a stronger influence as an inflammatory mediator. The mechanism Periodontitis is probably one of the pathologic insults to normal gestational function and causes adverse outcomes (APOs).

Design: A Cross-sectional survey was conducted among female sample in Benghazi city. A structured interview questionnaire was used in this study.

Results: Two hundred and nine female their age ranged between 20 to 60 years were participated in the study. 38.9% of the participating females have known that there is an association between periodontal disease PD and general health. But only 31.4% knew that PD increases during pregnancy (younger age group). Despite that 43.3% of the sample was aware about the symptoms of PD, 50.2% did not visit a dentist for more than one year and only 14.8% visited a dentist when there is pain or discomfort. Whereas, 88% of the sample had no idea that there could be an association between PD and adverse pregnancy outcome.

Conclusion: There was a deficiency in the knowledge of female population about periodontal disease in relation to hormonal changes and the adverse effects on pregnancy.
Vasovagal presyncope response misdiagnosed as an allergic reaction to local anesthesia: A case report
Authors: Elsagali Abeer Hussen , Elmezwghi Abdurahman Musbah , Ashmmam Musbah
Published: December 2023

Presyncope is often defined as a temporary light-headed or dizzy feeling or a transitory reduction but not loss of consciousness. The presyncope vasovagal response can be triggered by stress, prolonged standing, extreme emotions, or severe pain, it occurs due to a reflex bradycardia and peripheral vasodilation (hypotension). A diagnosis of presyncope is often difficult to make, it can quite easily be confused with other conditions. Adverse reactions to local anesthetics (LAs) are widely reported. These include dose-related toxic effects, subjective psychomotor symptoms and true allergic reactions. Although local anesthesia (LA) are well-tolerated drugs, they precipitate adverse reactions. True allergic reaction represents only 1% of adverse reactions to local anesthetics (LAs).The diagnosis of unexpected adverse reactions during local anesthesia is a difficult issue. Nevertheless, Diagnosis may be confirmed with clinical presentation and skin test results. It is common for dental practitioners to misdiagnose a serious adverse event to LAs as an allergic reaction. The aim of this report is to determine knowledge of the dental practitioner about the proper history, symptoms, signs, investigations and how to differentiate between presyncope vasovagal reflex and allergic reaction of dental local anesthesia
The influence of age and gender on mandibular indices in sample of Libyan population
Authors: Bin Hareiz Asma
Published: December 2023

Radiographic Mandibular Indices serve as easy and relatively cheap tools for evaluating bone mineralization.Objectives: To examine the effect of age and gender on three mandibular indices: the panoramic mandibular index (PMI), the mandibular ratio (MR) and the mandibular cortical index (MCI), among Libyan population.Methods: the three indices were measured on 317 digital (OPGs) of adult humans (155 males, 162 females). The sample was divided into six age groups (from 18-25 years. through 56-65 years). The measurements were analyzed for interactions with age and sex, using SPSS (Statistical Package for Social Studies) software version no. 22. The tests employed were two way ANOVA, the unpaired T-test and chi-square test. Results: The mean PMI fluctuated between 0.37 s.d. 0.012 and 0.38 s.d. 0.012.among the sixth age groups. One-way ANOVA statistical test revealed no significant of age on PMI. On the other hand gender variation has effect on PMI, since independent sample t-test disclosed that the difference between the male and female PMI means statistically significant. ANOVA test showed that the means of MR among age groups showed a negative correlation i.e. MR mean declined from 3.01 in 18-25 age group to 2.7 in 55-65 age group. In contrary, the gender showed no effect on MR according two sample t-test at p> 0.05. In regards with MCI, statistical analysis showed that it affected by age that is C1 was decreasing by age while C2 and C3 were increased by age. Using chi square test the result indicated that there is a significant difference among the different age group and the two genders in MCI readings. Conclusion: PMI was influenced significantly by age but minimally by the gender. MR is not affected by gender but has a negative correlation with age. MCI is affected by both age and gender.
The effects of adding zirconium oxide Micro-particles to high impact polymethyl methacrylate on some mechanical properties
Authors: Elgtlawi Dr.Mohamed , Saleh Dr.Amel M , O Elaogal Mr.Omar
Published: December 2023

Aim: The purpose of this study was to investigate the transverse strength and impact strength of high impact heat-cured Poly (Methyl Methacrylate) (PMMA) reinforced with zirconium oxide particles (ZrO2).
Materials and Methods: A total of sixty specimens were fabricated for each test. The denture base materials evaluated in this study were divided equally into three groups (A), (B) and (C) for each test. group (A) control group, unmodified high impact heat cured (PMMA). Group (B) ‎&‎ ‎(C) high impact heat cured (PMMA) reinforced with 5% ‎&‎ ‎10% (ZrO2) powder respectively by volume. The transverse strength was measured using the three point bending test. The impact strength was measured using the Chrapy impact tester. The micro-structural study of the fracture surfaces of test specimens ‎was performed using Scanning Electron Microscope.
Results: Statistical analysis were conducted on the data obtained from the experiments using one way analysis of variance(ANOVA).Both ‎the transverse strength and impact strength of high impact heat cured PMMA reinforced with ‎treated ZrO2 particles were superior to the unreinforced high impact heat cured PMMA. However, the improvement in transverse strength was not directly proportional with the amount of filler particles. Scanning electron micrographs showed the degree of bonding between the filler particles and PMMA matrix.
Endoscopic Endonasal Dacryocystorhiniostomy (EEDCR) (Libyan Experience)
Authors: Tuhami Mr.Masoud , Elbargathy Dr.Halima , A Belkhair Dr.Hussain , Elfleleh Mr.Salem , Gaber Dr.‎Salah , Omae ‎Mr.Salem
Published: December 2023

Endoscopic endonasal dacryocystorhiniostomy (EEDCR) is a valid alternative to external procedures in the management of nasolacrimal duct obstruction with success rate ranging from 82% to 95% . It is a less invasive procedure, can be done both under general and local anesthesia
Patients and methods: In the present study twenty patients (18 Females and 2 males), aged 17 to 65 years were studied in the period between May 2009 to March 2010 to determine the success rate of such operations. All cases were operated under general anesthesia with the help of zero endoscope and drill of lacrymal bone.
Results: Stents were applied in 5 recurrent cases after failed external approach, unresolved acute dacryocystites with abscess formation, and dacryocystocele. Few complications were encountered (such as granulation tissue at operative site in 4 cases, recurrence of symptoms due to incomplete removal of mucosal flap, and synechia between lateral nasal wall and middle turbinate).
Conclusion: After a follow up of 6 months the success rate in this series was 95%. Thus it is suggested that stent application should not be carried out routinely in every case, while close and regular follow up helps early identification of complications, early intervention and hence it decreases the recurrence and revision surgery.
Styloid Process Elongation, Shape and Calcification Pattern According to Age and Gender
Authors: Hamouda Dr.Saleh , Elmehadwi Dr.Huda , A.H. Mohamed Dr.Khadiga
Published: December 2023

Background: Styloid process (SP) is a slender pointed part of the temporal bone, which is closely related to the stylomastoid foramen. As many important neurovascular structures located near the tip of SP, the elongation or ossification of stylohyoid ligament may be associated with pain related to orofacial region known as Eagle’s syndrome.
Aim of this study was to assess the prevalence of elongated SP, its morphology and calcification pattern on digital panoramic radiographs in patients attending the dental clinic of the University of Benghazi.
Material and Methods: The digital panoramic radiographs with visible styloid processes of the studied group of patients were studied for their visibility, length and pattern of calcification. The length of styloid processes was measured in the radiograph and was considered elongated if that length exceeded 30 mm. The prevalence and pattern of elongation and calcification were determined according to Langlais classification.
Results: Out of the 304 patients (164 are males and 140 are females) examined radiographically, the elongation of SP was detected in 156 (51.31%) of the patients. It was bilateral in 151 (96.79%) cases. There were no significant differences between males and females in regard to the length and shape of SP between in all age groups in both sexes, but the calcification pattern was significantly different between the age groups in both sexes. The outlined pattern of calcification of SP was the most prevalent especially in the younger age group (10-19 years), while the complete calcification pattern was most commonly detected in the older age group (≥ 60 years).
Conclusion: elongated SP whether it is accompanied by pain symptoms or asymptomatic, can easily be detected on a digital panoramic radiograph and should be considered in the differential diagnosis of orofacial pain.
Oral Cancer Awareness Among Dental Patients in Benghazi, Libya : A cross- sectional Study
Authors: F. Awad Tufaha , S. Beaayou Hawwa , I. EL-Refadi Roba , M. Elmurtadi Ali
Published: December 2023

Background: Oral cancer is considered as one of the major public health problems in the coming decades. It is one of the most life-threatening conditions, and it is ranked as the 15th most common cancer in the world. Lack of awareness about the etiology, signs and symptoms of oral cancer might be the main causes of its delayed detection. Therefore, evaluation of patient’s awareness towards oral cancer can play an important role in early detection and will lead to better prognosis. The aim of this study is to assess the level of dental patients’ awareness towards oral cancer at Faculty of Dentistry, University of Benghazi.

Materials and Methods: A cross sectional study was conducted on dental patients during the academic year 2018-2019 at Faculty of Dentistry, University of Benghazi. Patients were surveyed for oral cancer awareness by using a pre-tested, self-administered questionnaire. The data was entered and tabulated into a computer using the Statistical Package for Social Science (SPSS Version 20 for Windows, SPSS Inc. Chicago, IL). Data analysis included descriptive  statistics.

Results: The response rate was 87.4%. The study popula­tion comprised of 39.3% females and 60.7% males. Low educated patients represented 23.2% of participants. The majority of them (77.1%) have heard about the term of oral cancer with the mass media constitute 38.3% of their information sources. Less than half of patients had the idea that growth of abnormal tissue and continuous pain in jaw are considered as early symptoms of the cancer. Only 23.9% of participates believed that smoking is considered as a risk factor of oral cancer.

Conclusion and Recommendation: There is a lack in the awareness of early signs, symptoms, and etiology of oral cancer. Therefore, an intensive public education program to recognize the early warning signs, symptoms and etiologies of the cancer is recommended. In additions, individuals should be encouraged for self-oral examination and regularly visit the dental clinics. This would play an important role in early recognition of the cancer and better prognosis would be expected.
Primary Malignant Tumors of Oral and Maxillofacial Region in Libyan Population: A single institution experience of 171 cases
Authors: Haroun Ghada , M Ali Mussa Asma , M Salama Hend , S Elgehani Amna
Published: December 2023

background: Globally, a significantly high rate of mortality was caused by oral cancer; however, epidemiological data of oral cancer is still scanty, particularly in Arab countries. This retrospective study was designed to provide a systematic analysis of the histological subtypes of oral and maxillofacial malignant neoplasms in Libyan population during two decades, and to compare the results with previous reports from Libya and other countries.

Method: data were gathered using patients medical record and biopsy files, and the histological slides were revaluated. The tumors were classified according WHO criteria (2017). 

Results: Carcinoma was found in 145 patients, forming (84.7%) of all the malignant oral and maxillofacial neoplasms, followed by lymphoma and sarcoma (6.4%), and neural crest cell tumours (2.3%). Males were more affected than females at a ratio of 1.3:1. Most of the patients (70.8%) were above the age of 40 with a mean age of 51.7years old at the time of the diagnosis. Only 1% of the malignant neoplasms were odontogenic in origin. Squamous cell carcinoma (67.5%) was the most common epithelial neoplasm, followed by mucoepidermoid carcinoma (9.7%) and adenoid cystic carcinoma (4.1%). The tongue was the most common site for squamous cell carcinoma (41.1%), followed by buccal mucosa (16.8%).

Conclusion: compared to previous reports from eastern and some western countries; the prevalence of malignant neoplasms of oral and maxillofacial region in Libyan populations is considerably low.
Prevalence of Developmental Dental Anomalies in A Sample of Adult Libyan Patients: Orthopantomographic Study
Authors: Hamad Magdi , Salem Khaled , Said Maraai
Published: December 2023

Objectives: This research was aimed to investigate the prevalence of dental anomalies among a selected adult   Libyan sample using panoramic radiographs.

Materials and Methods: Retrospective study of digital panoramic radiographs of (412) Libyan adult patients of both sexes (males and females). The data was collected from different Clinics in Benghazi district over six months period of time. The radiographs were studied on a computer screen to find out the developmental dental anomalies. Descriptive statistics and bivariate analysis by age and gender were conducted using SPSS software.

Results: A total of 412 panorama radiographs were used in the data analysis. The majority were females (273, 66%), aged between 18 and 70 years old.  The most common type of dental anomalies was dilaceration (130,31.6%), followed by impaction of wisdom teeth (66, 16%) and impaction of other teeth (23, 5.6%). A few cases of other anomalies were reported; these included one case of odontome, ectopic eruption of left upper 8 and one mesiodens. 

Conclusions: Dilaceration and impaction were the most common types of developmental dental anomalies among study population, with rare cases of supernumerary teeth and odontome. Multiple anomalies are common in the present study, suggestion genetic origin. The study showed that the prevalence of dental anomalies increases with the age of participants.
The dental workforce in Libya: an overlooked research topic
Authors: Arhoma Niroz , Arheiam Arheiam
Published: December 2023

EDITORIAL
Quality of Orthodontic Records Keeping: A clinical audit
Authors: Elsheikhi Fatma
Published: December 2023

Objectives:  To assess the quality of keeping orthodontic records. A further aim was to raise awareness of undertaking clinical audits to improve the quality of patient care.

Methods: Retrospective records of 50 patients undergoing orthodontic treatment at the Faculty of Dentistry, University of Benghazi, were collected to assess the quality of clinical record keeping in practice. The assessment was done by one orthodontist, by measuring 11 different criteria. Furthermore, to decide on any future changes to be done. Statistical analysis was done by descriptive analysis.

Results: The personal information were taken by 100%. Medical history was consistently checked but not updated or signed. 64% of cases came to the clinic with referral letters. The oral examination showed that 42% of patients had good oral hygiene, with 50% had fair oral hygiene, while, 8% with poor oral hygiene. 38% of patients had carious lesions. A form for treatment plan consent was not used, it had been taking verbally by 98%. The skeletal pattern showed, class I by 42%, class II was 52%, while class III accounted for 6%. On the other hand, dental malocclusion showed the following: 30% of class I, 56% class II division 1, 6% class II division 2 and class III 8%.

Conclusion: This self-audit highlights the shortcomings in the collected records.  Furthermore, this procedure shows how an audit can be performed in any area of orthodontics to improve the quality of patient care.
Nurses' Awareness of Patient Privacy and Confidentiality in Benghazi Medical Centre (BMC): A Cross-sectional Study
Authors: Omar Fatma Abdalla Atitalla , Eltarhuni Ainas Salem , Elamrony Randa Mahmoud Gadalla , Kutran Huda
Published: December 2023

Background:- Respect for the privacy of patients and the confidentiality of their information, personal data is a fundamental principle of patient rights. All healthcare providers, especially physicians and nurses play a crucial role as guardians of patient safety and rights  therefore this study aimed to assess the knowledge and awareness of patients’ rights among nurses at the Benghazi Medical Center.

Methods: A cross-sectional descriptive study was conducted with 184 nurses at the gynecology  and obstetrics department of the Benghazi Medical Center, using a self-administrated questionnaire. The questionnaire consisted of three parts: personal characteristics, and the knowledge towards privacy part (21 statements), and confidentiality (11 statements). Data analysis was carried out using SPSS version 23. Descriptive statistics (frequencies, percentages, means, and standard deviations) were used to describe the knowledge of privacy and confidentiality among nurses. A relation test was used to measure the association between privacy and confidentiality with personal data. Also, statistical significance was set at a P- value of <0.05.

Results: 67.9% of the nurses reported that they had experienced patient rights. The knowledge about privacy  among nurses in the target hospital was high, and the most common knowledge was: during the examination, treatment, and care, all healthcare professionals should be careful about the protection of patient privacy (91.8%) and nursing care to protect privacy in the work environment (91.3%). Concerning confidentality, nurses had a high level of knowledge in general, and the highest level of knowledge was in the statement ‘patients must get all kind of health service in an environment that is suitable for confidentiality’.  The result found there was no association between personal characteristics and privacy and confidentiality.

Conclusion:- It was concluded that nurses commonly encounter patient rights issues in their workplace. However, the majority of the nurses who participated in the study had a very good level of knowledge about privacy and confidentiality. Age, educational level or length of working experience was insignificantly associated with the level of knowledge of privacy and confidentiality.
Using Least Square for Develop a New Formation Resistivity Factor Correlation and Relationship between the Salinity and the Corrosion
Authors: Mazeb Neima , AlFadil Nassr
Published: December 2023

Formation resistivity factor (Fr),introduced by Archie , is an important parameter for electric log interpretation .It is defined as the resistivity of rock fully saturated with brine (Ro) divided by the resistivity of brine (Rw). This factor is function of porosity, resistivity, tortuosity and cementation factor, which are consequently affected also by particle size and degree of compaction .Formation resistivity factor is usually determined experimentally or by using empirical approach. During the present paper, we try to develop a new formation resistivity factor (Fr) correlation based on statistical methods, Least square, by taking into account different parameter such as brine salinity, particle size and degree of compaction. In addition, this study aims to determine the relationship between salinity and corrosion.
Energy and Exergy Analysis for Unit13E1 of Benghazi Combined Cycle Power Plant
Authors: Elfeituri Idris , El Gehani Hamza
Published: December 2023

Presented in this paper, an exhaustive energy-exergy analysis of a 476 MW combined cycle power plant located in Benghazi-Libya, as an example to illustrate the utility and importance of exergy analysis compared with energy analysis.  The proposed power plant cycle was simplified into sub-systems and modelled. These models of mass, energy and exergy balance equations were applied to each sub-system and farther validated by the manufacturer’s data at design operating condition. The results indicate that, the power plant has an overall energy and exergy efficiencies of 55.0% and 52.0% respectively. The total exergy destruction rate is found to be 444.2 MW (48.3 % of fuel input exergy). Significant exergy destruction rate is found to occur in the combustion chamber which contributes a major share of 340.7 MW (37.06%), followed by heat recovery steam generator with 35.7MW (4. %). Moreover, the results of the exergy analysis are compared with those of energy analysis. The comparison is quite of interest. The exergy analysis is much more enlightening, because the dissipations and efficiencies measured with availability are true one, where as those measured with energy are erroneous and misleading. The benefit of this study has enabled us to identify sites where loss of useful energy (exergy) takes place in a power plant and its performance can be evaluated. The results presented here are of real practical value in many ways, they can be valuable for the academic research interest.
Evaluation of the Synergistic Effect of the Combination of Doxorubicin and Vorinostat on Breast Tumor Cells Using the Loewe Model
Authors: Mollaeva М. R. , Yabbarov N. G. , Sokol М. В. , Chirkina М. V. , Nikolskaya E. D.
Published: December 2023

The combination of two or more medications is increasingly more common in the development of new treatment guidelines for common diseases. Thus, the use of combinations of histone deacetylase inhibitors with chemotherapeutic agents is a current trend in solid tumor treatment. The aim of this study was to investigate an effective vorinostat (SAHA) to doxorubicin (DOX) ratio for the treatment of different subtypes of breast cancer. The survival of HCC-1954, SKBR-3, MCF-7, MCF-7/ADR, MDA-MB-231 cell lines was assessed under incubation conditions with 64 variants of SAHA and DOX combinations using the MTT assay. This made it possible to determine the effect of interactions of SAHA/DOX combinations (antagonistic, additive, synergistic), as well as calculate the SAHA/DOX synergy index using the Loewe additivity model. The effect of SAHA/DOX ratios with the highest synergistic index for each tumor cell line was confirmed using the Chou-Talalay method. It was shown that the SAHA/DOX combination exhibited the greatest synergism in relation to HCC-1954, MCF-7/ADR and SKBR-3 cell lines belonging to the HER2-positive subtype. The average value of SAHA/DOX ratio with the highest synergy against breast cancer cells was 30:1 (SAHA to DOX, respectively). The ability of SAHA/DOX combination to effectively trigger apoptosis was confirmed in the most sensitive to SAHA/DOX therapy HCC-1954 cells. Thus, the Loewe model made it possible to identify the drug combination with the highest synergistic anticancer effect, which was confirmed using Chou-Talalay method. The data obtained demonstrates great potential of SAHA/DOX combination (30:1) for the treatment of HER2-positive breast cancer.
The Estimation of Efficacy of Nonspecific Medications Against Hemorrhagic Fevers Caused by Arenaviruses
Authors: Sizikova Т. Е. , Lebedev V. N. , Borisevich S. V.
Published: December 2023

The article presents an analysis of studies assessing the effectiveness of new nonspecific medications against hemorrhagic fevers caused by arenaviruses. The possible targets for nonspecific medications, classes of researched antiviral preparations, methods of preclinical investigation of antiviral preparations in vitro and on laboratory animals, as well as prospects for their use in healthcare at present are considered. It has been shown that the level of development of nonspecific medications against hemorrhagic fevers caused by arenaviruses is significantly inferior to those against filovirus infections. Favipiravir should currently be considered as the most effective nonspecific medication against hemorrhagic fevers caused by arenaviruses.
Changes in the Etiological Structure and Specifics When Choosing Antibacterial Therapy Against Infective Endocarditis in Pediatric Practice
Authors: Danilov А. I. , Evseev А. V. , Avdeeva Т. G. , Legonkova Т. I. , Zharkova L. Р.
Published: December 2023

Infective endocarditis in children is a rare disease, which often has an extremely serious prognosis. The most common risk factor for infective endocarditis in this category of patients is the history of congenital heart disease. At the same time, currently, the disruption of the integrity of the peripheral vascular bed is increasingly noted, among the predisposing causes, due to invasive diagnostic and therapeutic medical procedures, as well as severe somatic diseases. In accordance with the developed recommendations, the appointment of antibacterial therapy for infective endocarditis should be based on etiotropic orientation. Taking these circumstances into account, the article presents an overview of the data reflecting the issues of etiology and choice of antibacterial therapy for infective endocarditis in pediatric practice.
Communication Strategies and Organizational Harmony in Local Government Councils in Akwa Ibom State, Nigeria
Authors: Afangide Nsentip George , Iwok Uduot A. , Akarika Daniel Calixtus
Published: December 2023

This study examined communication strategies and organizational harmony in local government councils in Akwa Ibom State, Nigeria. The objectives of this study were to find out the communication strategies employed by the leadership of local government Councils in Akwa Ibom State, find out the rationale for the use of such communication strategies, determine if the communication strategies used by the leadership of local government councils in Akwa Ibom State do enhance organisational harmony, determine communication strategies preferred by the majority stakeholders in the local government councils studied, find out other factors that engender organisational harmony in the local government councils studied. The research design adopted for the study was survey, with questionnaire and interview schedule as research instruments. The population of the study were staff in Uyo, Eket and Ikot Ekpene local government councils in Akwa Ibom State is 1,374. A sample size of 286 was drawn for the study using the Taro Yamane formula. The study which anchored on System theory and the Interactional theory revealed that majority of the respondents in the council studied affirmed that sporting activities contributed to harmony in the council. Also, the study revealed that across the local government councils studied that religious activities similarly led to organisational harmony, the study found out that the leadership of the local government councils in Akwa Ibom State represented by Uyo, Eket and Ikot Ekpene utilised memo, letter, meeting, telephone, seminar and worship (solemn assembly) as a means of reaching out to their employees. Email was not used at all. It was recommended that local government councils should endeavour regularly to carry out communication audit to evaluate their performances. This should prove invaluable in helping them decide necessary changes that they need to make to ensure smooth running of the councils, the leadership of the local government councils need to incorporate the use of email for exchange of messages across the councils, telephone is an important tool that the councils use effectively in communication with subordinates. The principal officers and supervisors need to improve on their telephone etiquette, particularly in the use of language and tone during conversations. The impact of telephone in engendering interaction and relationships are overwhelming and should be embraced by the councils.
Directivas Médicas Anticipadas. Consideraciones a nivel federal y en la provincia de Córdoba 10 años después de la reglamentación de la ley 26.529
Authors: Ludueña Carolina M. , Casale Andrés J. A.
Published: December 2023

Las Directivas Médicas Anticipadas son declaraciones con el fin de dejar establecidas instrucciones relacionadas con la toma de decisiones vinculadas a la salud en momentos en los que no ya podrán ser exteriorizadas. Los derechos del paciente y las D.M.A. nunca estarán exentas de debates éticos, jurídicos y médicos. Se advierten dos aspectos problemáticos en el instituto analizado, uno vinculado a la sistematización de las historias clínicas y otro a los registros provinciales de D.M.A. Si bien la puesta en práctica de registros de D.M.A es un gran primer paso para una solución, la implementación de la historia clínica digital única abre un camino fundamental para el respeto de los derechos del paciente en general y el respeto de las D.M.A. en particular. La implementación del Programa Federal Único de Informatización y Digitalización de Historias Clínicas a través de la ley 27.706 se enmarca en esa línea.
Asistente personal y apoyos a personas con discapacidad. Un análisis del alcance de la cobertura por parte de Obras Sociales y el Estado en relación con la jurisprudencia argentina
Authors: Blanco Pighi María Florencia , Gastaldi Paula
Published: December 2023

El presente artículo plantea el análisis de jurisprudencia argentina seleccionada en la que se trató el régimen de asistencia a personas con discapacidad y la obligatoriedad de las obras sociales en otorgar esta cobertura, entendiendo que la misma se encuentra garantizada por la normativa nacional y supranacional vigente en nuestro país. Además, se pretende identificar los argumentos que ofrecen las obras sociales para denegar cobertura, centrándonos en desvirtuar la falacia de “crack económico” en el que caerían las empresas si hicieran lugar a la cobertura de éste tipo de prestaciones.
La aplicación del dictamen médico en el seguro obligatorio de siniestros laborales: el caso peruano
Authors: García Asencios Frank
Published: December 2023

Mediante la Ley de Modernización de la Seguridad Social en Salud, Ley N° 26790, se regula el Seguro Complementario de Trabajo de Riesgo (SCTR) en el sistema peruano, un seguro de caracter obligatorio a cargo del empleador en beneficio de los trabajadores que realizan labores de alto riesgo, a fin de dar cobertura a siniestros laborales como accidentes de trabajo y enfermedades profesionales. No obstante, una de las problemáticas es el dictamen, informe o examen médico que sirve de sustento para determinar el beneficio económico a favor del asegurado una vez suscitado el siniestro, debido a que en el mismo procedimiento pueden presentarse innumerables dictámenes, informes o examenes médicos con o sin menoscabos, lo que generan incertidumbre sobre su real condición de invalidez. En tal sentido, se reflexiona sobre el SCTR en el sistema peruano y desarrolla los pronunciamientos del Tribunal Constitucional sobre el valor probatorio de los dictámenes, informes o examenes médicos.
A Convenção Europeia de Direitos Humanos e a Corte de Estrasburgo na proteção aos direitos fundamentais da União Europeia
Authors: Lanner De Camillis Lucas , Regina Martini Sandra , Macedo Fernandes Karina
Published: December 2023

O presente artigo tem por objetivo demonstrar como ocorreu a evolução dos direitos humanos dentro do ordenamento jurídico comunitário da União Europeia e qual foi à influência que a Corte de Estrasburgo e a própria Convenção Europeia de Direitos Humanos teve dentro da organização internacional. A pesquisa foi feita com o método exploratório-bibliográfico de leituras em artigos, livros, jurisprudências, leis e tratados internacionais para complementar o máximo possível o entendimento sobre o assunto abordado. O trabalho começa com o debate sobre a influência da Corte Europeia de Direitos Humanos na vinculação desses direitos dentro do ordenamento jurídico comunitário e da jurisprudência do Tribunal Europeu, e o processo, ainda em curso, da adesão da própria União Europeia à Convenção Europeia de Direitos Humanos. Em seguida é analisado a intersecção e o entrelaçamento das Cortes (de Estrasburgo e de Luxemburgo), com a utilização de análises de casos concretos que são referentes dentro da jurisprudência europeia, que estavam vinculados com a proteção de direitos fundamentais na Europa, utilizando a intersecção de ambas as Cortes e seus entendimentos. E por fim uma breve análise de algumas complicações que o direito comunitário tem com o próprio direito internacional.
¿Qué ocurre cuando el TEDH confunde accesibilidad y ajustes razonables?
Authors: Úbeda Díaz Francisco
Published: December 2023

El caso Lárusson contra Islandia aborda cómo la falta de accesibilidad de dos centros sociales y culturales puede constituir una conculcación del artículo 14 en relación con el artículo 8 del Convenio; no obstante, esta no fue la decisión tomada por el TEDH puesto que consideró que el municipio estaba avanzando hacia los objetivos de plena accesibilidad y, en consecuencia, exigirle su inmediata adaptación supondría una carga desproporcionada o indebida. El presente comentario desarrollará los conceptos de accesibilidad, ajustes razonables y vida privada además de analizar la opinión disidente del juez Zünd.
El control estatal sobre el autocultivo de cannabis con fines medicinales
Authors: Álvarez Eugenia
Published: December 2023

El presente trabajo tiene por objeto analizar lo resuelto por la Corte Suprema de Justicia de la Nación con fecha 5 de julio de 2022 en el marco de la causa caratulada “Asociación Civil Macame y otros c/ Estado Nacional Argentino - P.E.N. s/ amparo ley 16.986”, en la cual se trató la acción de amparo interpuesta por una asociación civil junto con un grupo de madres a fin de que se les garantizara el acceso gratuito al aceite de cannabis sin forzar a los niños a someterse a un programa estatal de investigación experimental, y cuestionando toda aquella norma que prohibiera el autocultivo para el consumo medicinal de los menores de edad a su cargo.  El máximo tribunal rechazó por unanimidad la acción intentada, afirmando que el Estado se encuentra obligado por nuestra Constitución Nacional  a adoptar medidas tendientes a salvaguardar el derecho a la salud, y que el registro creado con tales fines –Reprocann– implicaba un control estatal razonable.
Medida autosatisfactiva: una vía judicial de protección de la salud
Authors: Vulcano Gianna Donatella
Published: December 2023

Se analizará la causa “T., A. M. y Otro – Solicita Homologación – Ley 10.305”, en la cual el día 12/05/2022, el Juzgado de Familia de Segunda Nominación, hizo lugar a una medida autosatisfactiva, y ordenó a la obra social, que de manera urgente proceda a afiliar y brindar cobertura al menor gravemente enfermo, a cargo y bajo el exclusivo costo de su progenitor.
Límites de las medidas curativasen salud mental
Authors: Sandoval Junyent Sebastián
Published: December 2023

Las medidas curativas, en el marco de un proceso penal en el que se declaró inimputable al victimario de un delito de homicidio en razón de padecer problemas serios de salud mental, deben tener un límite, según sostiene el máximo tribunal cordobés.
El punto de partida es la salud, en este caso del victimario, como derecho humano y fundamental. Por ello, las medidas curativas no pueden transformarse en prisión, sino en un tratamiento más para lograr la mejor recuperación posible de la persona que padece alguna enfermedad mental.
La legislación incorpora principios y normas que van en esa dirección. Aún así, resulta necesario incorporar pautas que hagan operativos aquellos principios de dicha ley y de los tratados internacionales en la materia.
En el marco de un proceso penal, se declaró inimputable al victimario, por razones de salud mental. En la etapa de ejecución de la pena, el tribunal ordenó el cese de las medidas curativas y, en consecuencia, la externación del victimario. La resolución impugnada se fundó en las pericias psiquiátricas oficiales y lo dispuesto por ley 26.657. La parte querellante interpone recurso de casación y el TSJ resuelve confirmar el cese de las medidas curativas.
Diseño de una Bomba de Ariete Hidráulico para suministrar agua en el centro poblado San Juan de Tunguillan-Las Pirias, Jaén-Cajamarca
Authors: Díaz reyes Carlos Mario , Segura Peña Segundo Michel
Published: December 2023

El objetivo de la investigación fue diseñar un sistema de bombeo hidráulico a base del principio de golpe de ariete, para suministrar una demanda de agua, al Centro Poblado San Juan de Tunguillan-Las Pirias, Jaén-Cajamarca. El estudio fue aplicativo y experimental, conformada por tres viviendas, cada una constituida por cinco miembros. Se utilizó la observación directa, técnica analítica, análisis documental y el programa SolidWorks, para diseño y simulación. La determinación de la cantidad de agua/ hab se realizó según Norma I.S.010, la cual fue 150 L/hab/día; el promedio del caudal de suministro fue 34.168 L/min; la potencia de la bomba fue 55.85 W. La simulación de la bomba de ariete hidráulico evidenció que el diseño fue funcional, para el suministro de agua.
From traditional to digital: The impact of drones and virtual reality technologies on educational models in the post-epidemic era
Authors: Lu Jiaxin , Dawod Ahmad Yahya , Ying Fangli
Published: December 2023

Employment of various innovative tools for education in the post-epidemic era is an urgent issue of improving the quality and efficiency of education and the relevance of educational material. The study aims to investigate the impact of the use of drones and virtual reality in educational models of student learning in the post-pandemic period. The study was conducted using a quantitative method, a sociological survey, a pedagogical experiment, and mathematical processing of the results. The study involved fourth-year students (n=748) studying in the following specialties: geography and ecology (n=119), engineering, robotics (n=135), architecture and urban planning (n=120), agriculture, agronomy (n=118), information technology (IT) (n=139), journalism (n=117), and teachers (n=258) with more than 5 years of experience. For the educational process of students of each specialty, the scope of application of drones and virtual reality has been developed. Classes with the use of drones and virtual reality were held two times a week for one academic semester. Afterward, students were interviewed using an adapted questionnaire to study their attitudes toward virtual reality technologies and drones for learning. Students of all specialties positively evaluated various aspects of the use of drones and virtual reality in their educational process. The use of drones helps to improve student engagement and visual attention and has a positive impact on learning efficiency and student satisfaction with the learning process. Teachers approve of the use of drones and virtual reality in teaching but point out that further development of the methodology for training stakeholders in the educational process, infrastructure, improvement of curricula, and consideration of various aspects of technology use is needed to effectively implement drones and virtual reality in the learning process. The practical significance of this study is to present aspects of the use of drones in teaching students of certain specialties and to study the impact of the effectiveness of the use of these technologies on the opinions of students and teachers.
Enhancing BYOD mobile device security in a hybrid environment
Authors: Ahmadov Samur
Published: December 2023

Research on enhancing Bring Your Own Device (BYOD) security in hybrid environments is critically relevant and important to protect data and ensure customer and organizational trust through the development of strong security policies. The study aims to develop and implement effective strategies and interventions that will help ensure that corporate data and resources are protected when employees use personal mobile devices in an environment where both on-premises and cloud-based resources are present. The methods used include analytical, deduction, modeling, statistical, and synthesis methods. This research identified specific vulnerabilities of potential threats to BYOD mobile devices in a hybrid environment and developed security strategies that include recommendations for creating a security policy and using a mobile device management system. The research led to the development of specific technical solutions, such as recommendations for mobile device configuration. This included educating employees and managers about security rules and the importance of adhering to security policies, and updated lists of current BYOD security threats and challenges given the changing threat environment. The practical value of the work lies in providing practical relevance to organizations by providing robust protection of sensitive data and resources, increasing employee comfort and confidence in the security of personal devices, easing IT departments’ tasks of device management and threat detection, and increasing customer and partner confidence in a security-layer organization.