bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro Effect of Withania somnifera, Mucuna pruriens and Pausinystalia johimbe on Hepatic Cytochrome P450 in Rat
Authors: Sultana Rajia , Sultan Md Zakir
Published: August 2018

The effect of Withania somnifera, Mucuna pruriens and Pausinystalia johimbe extracts on hepatic cytochrome P450 enzyme CYP3A4 activities was studied using rat liver microsomes. CYP3A4- dependent testosterone 6β-hydroxylation activities were determined by ELISA. In the study, rats were treated with W. somnifera (0.5 g/kg/day), M. pruriens (0.5 g/kg/day) and P. johimbe (0.25 g/kg/day) extracts for 20 days. It was found that W. somnifera, M. pruriens and P. johimbe extracts showed potent to moderate inhibitory effect on CYP3A4 activities in rat liver microsomes, with IC50 values of 18.01 ng/mL, 14.93 ng/mL and 21.03 ng/mL, respectively.Bangladesh Pharmaceutical Journal 21(2): 118-122, 2018
In vivo CNS Activity of Methanolic Extract of Ficus racemosa Fruits in Experimental Animals
Authors: Munira Mst Shirajum , Islam Md Shariful , Baharuddin Md , Koly Sabiha Ferdowsy
Published: August 2018

The purpose of the study was to evaluate the CNS activity of the methanolic extract of Ficus racemosa fruits. The powdered fruits of F. racemosa were extracted with methanol to investigate the effect on central nervous system in Swiss albino mice. The CNS depressant activity was evaluated by observing the reduction of locomotor activity by open field and hole cross tests. The anti-depressant activity was tested by forced swimming and tail suspension methods. For CNS activity, two test doses of the extracts such as 200 and 400 mg/kg body weight were used. However, the extracts showed significant dose dependent CNS depressant activity when compared to the control in animal models. From our research, it can be concluded that the methanolic extract of F. racemosa fruits possesses significant CNS depressant activity. So, further studies are recommended for the isolation of compounds responsible for this activity.Bangladesh Pharmaceutical Journal 21(2): 139-144, 2018
A Short Review on Phytoconstituents from Genus Albizzia and Erythrina
Authors: Hussain Mohammad Musarraf
Published: August 2018

The genus Albizzia and Erythrinaare the leading sources of phytoconstituents. The aim of this review is to solicitude of the phytoconstituents from some medicinal plants of these genus. A total nine medicinal plants were studied and 121 chemical constituents along with structures have been reported here. Erythrina burttii consists of highest number of constituents.Bangladesh Pharmaceutical Journal 21(2): 160-172, 2018
New Drug Approvals Vol.21(2)
Authors: Hossain Md Akbar
Published: August 2018

Abstract not availableBangladesh Pharmaceutical Journal 21(2): 173-175, 2018
New Indications & Dosage form for Existing Drugs Vol.21(2)
Authors: Hossain Md Akbar
Published: August 2018

Abstract not availableBangladesh Pharmaceutical Journal 21(2): 176-178, 2018
Current Pharma News Vol.21(2)
Authors: Hossain Md Akbar
Published: August 2018

Abstract not availableBangladesh Pharmaceutical Journal 21(2): 179-180, 2018
Special Issue on Socio-Cognitive and Affective Computing
Authors: Fernández-Caballero Antonio , González Pascual , López María T. , Navarro Elena
Published: August 2018

Social cognition focuses on how people process, store, and apply information about other people and social situations. [...]
Feature Selection and Transfer Learning for Alzheimer’s Disease Clinical Diagnosis
Authors: Zhou Ke , He Wenguang , Xu Yonghui , Xiong Gangqiang , Cai Jie
Published: August 2018

Background and Purpose: A majority studies on diagnosis of Alzheimer’s Disease (AD) are based on an assumption: the training and testing data are drawn from the same distribution. However, in the diagnosis of AD and mild cognitive impairment (MCI), this identical-distribution assumption may not hold. To solve this problem, we utilize the transfer learning method into the diagnosis of AD. Methods: The MR (Magnetic Resonance) images were segmented using spm-Dartel toolbox and registrated with Automatic Anatomical Labeling (AAL) atlas, then the gray matter (GM) tissue volume of the anatomical region were computed as characteristic parameter. The information gain was introduced for feature selection. The TrAdaboost algorithm was used to classify AD, MCI, and normal controls (NC) data from Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, meanwhile, the “knowledge” learned from ADNI was transferred to AD samples from local hospital. The classification accuracy, sensitivity and specificity were calculated and compared with four classical algorithms. Results: In the experiment of transfer task: AD to MCI, 177 AD and 40NC subjects were grouped as training data; 245 MCI and 45 remaining NC subjects were combined as testing data, the highest accuracy achieved 85.4%, higher than the other four classical algorithms. Meanwhile, feature selection that is based on information gain reduced the features from 90 to 7, controlled the redundancy efficiently. In the experiment of transfer task: ADNI to local hospital data, the highest accuracy achieved 93.7%, and the specificity achieved 100%. Conclusions: The experimental results showed that our algorithm has a clear advantage over classic classification methods with higher accuracy and less fluctuation.
Interface Engineering Strategies for Fabricating Nanocrystal-Based Organic–Inorganic Nanocomposites
Authors: Jung Jaehan , Chang Mincheol , Yoon Hyeonseok
Published: August 2018

Hybrid organic–inorganic nanocomposites have attracted considerable attention because they have the advantages of both conjugated polymers (CPs) and nanocrystals (NCs). Recent developments in the interfacial engineering of CP–NC organic–inorganic nanocomposites enabled the formation of an intimate contact between NCs and CPs, facilitating electronic interactions between these two constituents. To design CP–NC nanocomposites, several approaches have been introduced, including ligand refluxing, direct grafting methods, direct growth of NCs in proximity to CPs, and template-guided strategies. In this review, the general reactions of ligand exchange processes, purification methods, and characterization techniques have been briefly introduced. This is followed by a highlight of recent advances in the synthesis of hybrid CP–NC nanocomposites and newly developed inorganic surface treatments, as well as their applications. An outlook for future directions in this area is also presented.
Improved Methods for the Rapid Formation and Prevention of Advanced Glycation End Products (AGEs) In Vitro by Coupling to the Hypoxanthine/Xanthine Oxidase Assay System
Authors: Marques Samuel , Trevisan Teresa , Maia Carlos , Breuer Andrea , Owen Robert W.
Published: August 2018

Advanced glycation end products (AGEs) represent a set of molecules that contribute directly to the initiation and aggravation of diseases associated with ageing. AGEs are produced by the reaction between reducing sugars (or α-dicarbonyl compounds), proteins, and amino acid residues. Previous in vitro methods using non-enzymatic procedures described in the literature require an incubation period of 1–3 weeks to generate AGEs. In this study, the reaction time for the formation of AGEs (48 and 3 h) was significantly reduced by adaptation of methods previously described in the literature and coupling them to the free radical generation system termed hypoxanthine/xanthine oxidase assay. The incorporation of this assay into the experimental system accelerated the production of AGEs as a result of the formation of reactive oxygen species (ROS), as shown by increased fluorescence. The capacity of different classes of chemical compounds (aminoguanidine, chlorogenic acid, rutin, and methanol extracts of Hancornia speciosa Gomes) to inhibit protein glycation by acting as scavenging agents of α-dicarbonyl species was evaluated. Aminoguanidine and, especially, rutin identified in the leaf extracts of H. speciosa Gomes showed a high capacity to act as scavengers of reactive carbonyl species RCS-trapping, resulting in the inhibition of AGEs formation.
Measuring and Calculating Current Atmospheric Phosphorous and Nitrogen Loadings to Utah Lake Using Field Samples and Geostatistical Analysis
Authors: Olsen Jacob M. , Williams Gustavious P. , Miller A. Woodruff , Merritt LaVere
Published: August 2018

Atmospheric nutrient loading through wet and dry deposition is one of the least understood, yet can be one of the most important, pathways of nutrient transport into lakes and reservoirs. Nutrients, specifically phosphorus and nitrogen, are essential for aquatic life but in excess can cause accelerated algae growth and eutrophication and can be a major factor that causes harmful algal blooms (HABs) that occur in lakes and reservoirs. Utah Lake is subject to eutrophication and HABs. It is susceptible to atmospheric deposition due to its large surface area to volume ratio, high phosphorous levels in local soils, and proximity to Great Basin dust sources. In this study we collected and analyzed eight months of atmospheric deposition data from five locations near Utah Lake. Our data showed that atmospheric deposition to Utah Lake over the 8-month period was between 8 to 350 Mg (metric tonne) of total phosphorus and 46 to 460 Mg of dissolved inorganic nitrogen. This large range is based on which samples were used in the estimate with the larger numbers including results from “contaminated samples”. These nutrient loading values are significant for Utah Lake in that it has been estimated that only about 17 Mg year−1 of phosphorus and about 200 Mg year−1 of nitrogen are needed to support a eutrophic level of algal growth. We found that atmospheric deposition is a major contributor to the eutrophic nutrient load of Utah Lake.
Responses of Transgenic Melatonin-Enriched Goats on LPS Stimulation and the Proteogenomic Profiles of Their PBMCs
Authors: Yang Minghui , Tao Jingli , Wu Hao , Zhang Lu , Yao Yujun , Liu Lixi , Zhu Tianqi , Fan Hao , Cui Xudai , Dou Haoran , Liu Guoshi
Published: August 2018

The anti-inflammatory activity of melatonin (MT) has been well documented; however, little is known regarding endogenously occurring MT in this respect, especially for large animals. In the current study, we created a MT-enriched animal model (goats) overexpressing the MT synthetase gene Aanat. The responses of these animals to lipopolysaccharide (LPS) stimulation were systematically studied. It was found that LPS treatment exacerbated the inflammatory response in wild-type (WT) goats and increased their temperature to 40 °C. In addition, their granulocyte counts were also significantly elevated. In contrast, these symptoms were not observed in transgenic goats with LPS treatment. The rescue study with MT injection into WT goats who were treated with LPS confirmed that the protective effects in transgenic goats against LPS were attributed to a high level of endogenously produced MT. The proteomic analysis in the peripheral blood mononuclear cells (PBMCs) isolated from the transgenic animals uncovered several potential mechanisms. MT suppressed the lysosome formation as well as its function by downregulation of the lysosome-associated genes Lysosome-associated membrane protein 2 (LAMP2), Insulin-like growth factor 2 receptor (IGF2R), and Arylsulfatase B (ARSB). A high level of MT enhanced the antioxidant capacity of these cells to reduce the cell apoptosis induced by the LPS. In addition, the results also uncovered previously unknown information that showed that MT may have protective effects on some human diseases, including tuberculosis, bladder cancer, and rheumatoid arthritis, by downregulation of these disease-associated genes. All these observations warranted further investigations.
Oviplate: A Convenient and Space-Saving Method to Perform Individual Oviposition Assays in Aedes aegypti
Authors: Ioshino Rafaella Sayuri , Carvalho Danilo Oliveira , Marques Isabel Cristina Santos , Fernandes Ediane Saraiva , Capurro Margareth Lara , Costa-da-Silva André Luis
Published: August 2018

Aedes aegypti is the principal vector of the urban arboviruses and the blood ingestion is important to produce the eggs in this species. To analyze the egg production in Ae. aegypti, researchers frequently use small cages or Drosophila vials to collect eggs from gravid females. Although it is affordable, the setup is time- and space-consuming, mainly when many mosquitoes need to be individually analyzed. This study presents an easy, cheap, and space-saving method to perform individual oviposition assays in Ae. aegypti using cell culture plates. This new method to access fecundity rate was named “oviplate”. The oviplates are setup with 12- or 24-well plates, distilled water and filter paper and they are 78 to 88% cheaper than the traditional Drosophila vial assay, respectively. Furthermore, to allocate 72 vitellogenic females in an insectary using Drosophila vial is necessary 4100 cm3 against 1400 cm3 and 700 cm3 when using 12- and 24-well plates, respectively. No statistical differences were found between the number of eggs laid in Drosophila vials and the oviplates, validating the method. The oviplate method is an affordable, and time- and space-efficient device, and it is simpler to perform individual fecundity analyses in Ae. aegypti.
Primary Signet Ring Cell Carcinoma of the Prostate: A Rare Case Report
Authors: Gök Alper , Tuygun Can , Akmansu Müge , Uslu Ayşegül , Kartal Ibrahim , Sandikçi Fatih , Karabacak Osman , Sağnak Azmi , Topaloğlu Hikmet , Ersoy Hamit
Published: August 2018

Primary prostatic signet ring cell carcinoma is a rare form of cancer with a poor prognosis, which is generally treated with a traditional prostate adenocarcinoma therapy. This case report presents a 70-year-old diagnosed with primary prostatic signet ring cell carcinoma, treated with a combination of radiotherapy and hormone therapy and a 16 month survival without an evidence of the disease at follow up.
New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164
Authors: Fan Yaqin , Wang Cong , Wang Liping , Chairoungdua Arthit , Piyachaturawat Pawinee , Fu Peng , Zhu Weiming
Published: August 2018

Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 μM, respectively.
From Lab on a Chip to Point of Care Devices: The Role of Open Source Microcontrollers
Authors: Nguyen Trieu , Zoëga Andreasen Sune , Wolff Anders , Duong Bang Dang
Published: August 2018

Microcontrollers are programmable, integrated circuit chips. In the last two decades, their applications to industrial instruments, vehicles, and household appliances have reached the extent that microcontrollers are now the number-one selling electronic chip of all kinds. Simultaneously, the field of lab-on-a-chip research and technology has seen major technological leaps towards sample handling, sample preparation, and sensing for use in molecular diagnostic devices. Yet, the transformation from a laboratory based lab-on-a-chip technology to actual point-of-care device products has largely been limited to a fraction of the foreseen potential. We believe that increased knowledge of the vast possibilities that becomes available with open source microcontrollers, especially when embedded in easy-to-use development environments, such as the Arduino or Raspberry Pi, could potentially solve and even bridge the gap between lab-on-a-chip technology and real-life point of care applications. The profuse availability and extraordinary capabilities of microcontrollers, namely within computation, communication, and networking, combined with easy-to-use development environments, as well as a very active and fast moving community of makers, who are eager to share their knowledge, could potentially be the difference between a dreadful “chip-in-a-lab”-situation, and the next successful start-up. Here follows a brief insight into how open source microcontrollers could potentially have a transformative effect on the field of lab-on-a-chip research and technology. Details in some specific areas of application are briefly treated before addressing challenges and future perspectives.
Transesterification of Lactic Acid Oligomers with Ethanol, a Way to Anhydrous Ethyl Lactate: A Kinetic Study
Authors: Figalla Silvestr , Petrůj Jaroslav , Švestková Tereza
Published: August 2018

A new method for the preparation of anhydrous ethyl ester of lactic acid was studied. The selected method is based on catalytic transesterification of lactic acid oligomers, which were prepared for this purpose by autocatalytic oligomerization of lactic acid. In this work, a kinetic model for the case of catalytic alcoholysis of oligoesters was derived assuming a first-order reaction and equimolar content of reactants in the reaction mixture. The model makes it possible to obtain the values of the reaction rate and equilibrium constants and the equilibrium alcohol concentration by regression analysis at one time. The model was verified by measuring the rate of consumption of ethanol over the time at various reaction temperatures with anhydrous FeCl3 as the catalyst. The reaction was studied at overpressure under autogenous conditions in the temperature range of 100–180 °C. For the catalyst concentration of 1 mol %, the activation energy value was 64.35 kJ·mol−1. The dependence of equilibrium composition and rate constant on the temperature was obtained. The derived model is generally applicable to all first-order equilibrium reactions. The presumption is that the forward and reverse reactions are of the same order and have the same stoichiometry and equivalent amounts of reactants at the beginning of the reaction.
Ecofriendly Palladium on Wool Nanocatalysts for Cyclohexene Hydrogenation
Authors: Ghadamgahi Sedigheh , Johnston James H. , Fonseca-Paris Carla
Published: August 2018

Use of natural wool fiber supports in the fabrication of novel composite materials incorporating metal nanoparticles, which offer the possibility of “environmentally friendly” catalytic materials, has been investigated. The catalytic hydrogenation of cyclohexene to cyclohexane by palladium nanoparticles immobilized on wool (Pd/wool) was studied using moderate pressure of pure hydrogen gas. The performance of wool-supported catalysts was explored over a palladium nanoparticle loading ranging from 1.6 to 2.6 wt %. The effect of the catalytic testing conditions, including stirring rate, amount of reactants, gas pressure, and target temperature were explored. A systematic series of catalytic-activity tests carried out at 400 psi H2 for 5 and 24 h reaction times at 40 °C using a stirring rate 750 rpm allowed us to identify differences in performance within the series of Pd/wool nanocatalysts studied. The most catalytically active samples contained Pd nanoparticles with average sizes of ca. 5 nm located predominantly on the surface and within the topmost layer of wool fibers, making them more accessible to the reactants.
Impact of a Modified Version of Baby-Led Weaning on Dietary Variety and Food Preferences in Infants
Authors: Morison Brittany J. , Heath Anne-Louise M. , Haszard Jillian J. , Hein Karen , Fleming Elizabeth A. , Daniels Lisa , Erickson Elizabeth W. , Fangupo Louise J. , Wheeler Benjamin J. , Taylor Barry J. , Taylor Rachael W.
Published: August 2018

The aim of this study was to determine whether food variety and perceived food preferences differ in infants following baby-led instead of traditional spoon-feeding approaches to introducing solids. A total of 206 women (41.3% primiparous) were recruited in late pregnancy from a single maternity hospital (response rate 23.4%) and randomized to Control (n = 101) or BLISS (n = 105) groups. All participants received government-funded Well Child care. BLISS participants also received support to exclusively breastfeed to 6 months and three educational sessions on BLISS (Baby-Led Weaning, modified to reduce the risk of iron deficiency, growth faltering, and choking) at 5.5, 7, and 9 months. Food variety was calculated from three-day weighed diet records at 7, 12, and 24 months. Questionnaires assessed infant preference for different tastes and textures at 12 months, and for ‘vegetables’, ‘fruit’, ‘meat and fish’, or ‘desserts’ at 24 months. At 24 months, 50.5% of participants provided diet record data, and 78.2% provided food preference data. BLISS participants had greater variety in ‘core’ (difference in counts over three days, 95% CI: 1.3, 0.4 to 2.2), ‘non-core’ (0.6, 0.2 to 0.9), and ‘meat and other protein’ (1.3, 0.8 to 1.9) foods at 7 months, and in ‘fruit and vegetable’ foods at 24 months (2, 0.4 to 3.6). The only differences in perceived food preferences observed were very small (i.e., <5% difference in score, at 12 months only). Infants following the modified Baby-Led Weaning were exposed to more varied and textured foods from an early age, but only an increased variety in ‘fruit and vegetable’ intake was apparent by two years of age.
Brain Health across the Lifespan: A Systematic Review on the Role of Omega-3 Fatty Acid Supplements
Authors: Derbyshire Emma
Published: August 2018

The brain is the most significant and complex organ of the human body. Increasingly, we are becoming aware that certain nutrients may help to safeguard brain health. An expanse of research has investigated the effects of omega fatty acids in relation to brain health but effects across the lifespan have not been widely evaluated. The present systematic review collated evidence from 25 randomized controlled trials (n = 3633) published since 2013. Compared with control groups, omega-3 supplementation generally correlated with improvements in blood biomarkers. Subsequently, these appear to benefit those with lower baseline fatty acid levels, who are breastfeeding or who have neuropsychiatric conditions. Whilst multiple studies indicate that omega fatty acids can protect against neurodegeneration in older adults, more work is needed in the years preceding the diagnosis of such medical conditions. Bearing in mind the scale of ageing populations and rising healthcare costs linked to poor brain health, omega supplementation could be a useful strategy for helping to augment dietary intakes and support brain health across the lifespan. Ongoing research is now needed using harmonious methodologies, supplement dosages, ratios and intervention periods to help formulate congruent conclusions.
New Polyhedral Oligomeric Silsesquioxanes-Based Fluorescent Ionic Liquids: Synthesis, Self-Assembly and Application in Sensors for Detecting Nitroaromatic Explosives
Authors: Li Wensi , Wang Dengxu , Han Dongdong , Sun Ruixue , Zhang Jie , Feng Shengyu
Published: August 2018

In this paper, two different models of hybrid ionic liquids (ILs) based on polyhedral oligomeric silsesquioxanes (POSSs) have been prepared. Additionally, these ILs based on POSSs (ILs-POSSs) exhibited excellent thermal stabilities and low glass transition temperatures. 1H, 13C, and 29Si nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were used to confirm the structures of the IL-POSSs. Furthermore, the spherical vesicle structures of two IL-POSSs were observed and were caused by self-assembly behaviors. In addition, we found it very meaningful that these two ILs showed lower detection limits of 2.57 × 10−6 and 3.98 × 10−6 mol/L for detecting picric acid (PA). Moreover, the experimental data revealed that the products have high sensitivity for detecting a series of nitroaromatic compounds—including 4-nitrophenol, 2,4-dinitrophenol, and PA—and relatively comprehensive explosive detection in all of the tests of IL-POSSs with nitroaromatic compounds thus far. Additionally, the data indicate that these two new ILs have great potential for the detection of explosives. Therefore, our work may provide new materials including ILs as fluorescent sensors in detecting nitroaromatic explosives.
Me, My Bot and His Other (Robot) Woman? Keeping Your Robot Satisfied in the Age of Artificial Emotion
Authors: Rousi Rebekah
Published: August 2018

With a backdrop of action and science fiction movie horrors of the dystopian relationship between humans and robots, surprisingly to date-with the exception of ethical discussions-the relationship aspect of humans and sex robots has seemed relatively unproblematic. The attraction to sex robots perhaps is the promise of unproblematic affectionate and sexual interactions, without the need to consider the other’s (the robot’s) emotions and indeed preference of sexual partners. Yet, with rapid advancements in information technology and robotics, particularly in relation to artificial intelligence and indeed, artificial emotions, there almost seems the likelihood, that sometime in the future, robots too, may love others in return. Who those others are-whether human or robot-is to be speculated. As with the laws of emotion, and particularly that of the cognitive-emotional theory on Appraisal, a reality in which robots experience their own emotions, may not be as rosy as would be expected.
Improvement in Surface Solar Irradiance Estimation Using HRV/MSG Data
Authors: Romano Filomena , Cimini Domenico , Cersosimo Angela , Di Paola Francesco , Gallucci Donatello , Gentile Sabrina , Geraldi Edoardo , Larosa Salvatore , T. Nilo Saverio , Ricciardelli Elisabetta , Ripepi Ermann , Viggiano Mariassunta
Published: August 2018

The Advanced Model for the Estimation of Surface Solar Irradiance (AMESIS) was developed at the Institute of Methodologies for Environmental Analysis of the National Research Council of Italy (IMAA-CNR) to derive surface solar irradiance from SEVIRI radiometer on board the MSG geostationary satellite. The operational version of AMESIS has been running continuously at IMAA-CNR over all of Italy since 2017 in support to the monitoring of photovoltaic plants. The AMESIS operative model provides two different estimations of the surface solar irradiance: one is obtained considering only the low-resolution channels (SSI_VIS), while the other also takes into account the high-resolution HRV channel (SSI_HRV). This paper shows the difference between these two products against simultaneous ground-based observations from a network of 63 pyranometers for different sky conditions (clear, overcast and partially cloudy). Comparable statistical scores have been obtained for both AMESIS products in clear and cloud situation. In terms of bias and correlation coefficient over partially cloudy sky, better performances are found for SSI_HRV (0.34 W/m2 and 0.995, respectively) than SSI_VIS (−33.69 W/m2 and 0.862) at the expense of the greater run-time necessary to process HRV data channel.
Highly Sensitive and Selective Colorimetric Detection of Methylmercury Based on DNA Functionalized Gold Nanoparticles
Authors: Xie Zheng-Jun , Bao Xian-Yu , Peng Chi-Fang
Published: August 2018

A new colorimetric detection of methylmercury (CH3Hg+) was developed, which was based on the surface deposition of Hg enhancing the catalytic activity of gold nanoparticles (AuNPs). The AuNPs were functionalized with a specific DNA strand (HT7) recognizing CH3Hg+, which was used to capture and separate CH3Hg+ by centrifugation. It was found that the CH3Hg+ reduction resulted in the deposition of Hg onto the surface of AuNPs. As a result, the catalytic activity of the AuNPs toward the chromogenic reaction of 3,3,5,5-tetramethylbenzidine (TMB)-H2O2 was remarkably enhanced. Under optimal conditions, a limit of detection of 5.0 nM was obtained for CH3Hg+ with a linear range of 10–200 nM. We demonstrated that the colorimetric method was fairly simple with a low cost and can be conveniently applied to CH3Hg+ detection in environmental samples.
Generalized Optical Design of the Double-Row Circular Multi-Pass Cell
Authors: Yang Zheng , Guo Yin , Ming Xianshun , Sun Liqun
Published: August 2018

A new design of circular multi-pass cells (CMPC) with two rows of reflection spots on mirrors is presented. The effective optical path length (OPL) of this novel CMPC is double that of traditional CMPC with the same diameter and interval of spots. This OPL can be readily adjusted to have regular intervals by rough rotation adjustment. We achieved a spatial separation of pre- and post-transfer optical systems that was adequately large even in the cases with a large number of passes. Analytical chief ray tracing analysis and a generalized method for parameter determination for designing the cell are presented in detail. The stable condition of the double-row CMPC (DR-CMPC) is also derived by the ABCD matrix method. Designs with maximum effective OPL of 74.72 m, 48.67 m and 24.57 m are demonstrated and verified by ray tracing simulations within a 25 cm diameter DR-CMPC. An adjustment of the regular intervals to 1 m can be achieved in both designs. The overall astigmatism of the design with an effective OPL of 74.72 m is only 9.30 × 10−6 mm, which is four orders of magnitude smaller than that of the traditional CMPC with similar geometric parameters.
Accurate Measurements of Wall Shear Stress on a Plate with Elliptic Leading Edge
Authors: Ding Guang-Hui , Ma Bing-He , Deng Jin-Jun , Yuan Wei-Zheng , Liu Kang
Published: August 2018

A micro-floating element wall shear stress sensor with backside connections has been developed for accurate measurements of wall shear stress under the turbulent boundary layer. The micro-sensor was designed and fabricated on a 10.16 cm SOI (Silicon on Insulator) wafer by MEMS (Micro-Electro-Mechanical System) processing technology. Then, it was calibrated by a wind tunnel setup over a range of 0 Pa to 65 Pa. The measurements of wall shear stress on a smooth plate were carried out in a 0.6 m × 0.6 m transonic wind tunnel. Flow speed ranges from 0.4 Ma to 0.8 Ma, with a corresponding Reynold number of 1.05 × 106~1.55 × 106 at the micro-sensor location. Wall shear stress measured by the micro-sensor has a range of about 34 Pa to 93 Pa, which is consistent with theoretical values. For comparisons, a Preston tube was also used to measure wall shear stress at the same time. The results show that wall shear stress obtained by three methods (the micro-sensor, a Preston tube, and theoretical results) are well agreed with each other.
A Low-Cost, Stand-Alone Sensory Platform for Monitoring Extreme Solar Overirradiance Events
Authors: Chase Otavio Andre , Teles Mailson Borges , De Jesus dos Santos Rodrigues Marinaldo , De Almeida José Felipe Souza , Macêdo Wilson Negrão , Da Costa Junior Carlos Tavares
Published: August 2018

In this paper, we present a low-cost, stand-alone sensory platform developed for in situ monitoring of environmental parameters, for use in the Amazon region in the north of Brazil. The mission of the platform is to perform monitoring and identification of overirradiance (solar irradiance > 1000 W/m2) and extreme overirradiance events (solar irradiance > 1300 W/m2) using a photovoltaic based irradiance sensor. The sensory platform was built using the ESP8266 microcontroller, an open embedded computer capable of Wi-Fi communication using the IEEE 802.11 standard, and small photovoltaic modules, air temperature, atmospheric pressure, voltage, and current sensors, enabling the development of a low-cost system (€70/R$350.00 BRL). Calibration and tests were conducted at the Federal University of Pará (UFPA), Belém campus, Pará, where the platform measured an extreme overirradiance of 1321 W/m2 at a low-latitude (1 °S) and low altitude (7 m above sea level).
Reliability of and Relationship between Flight Time to Contraction Time Ratio and Reactive Strength Index Modified
Authors: McMahon John J. , Lake Jason P. , Comfort Paul
Published: August 2018

Countermovement jump (CMJ) force-time testing is commonly used to monitor seasonal alterations in athletes’ CMJ strategy (to infer alterations in neuromuscular function). The flight time to contraction time (FT:CT) ratio and reactive strength index modified (RSImod) are considered to be two primary CMJ variables of interest. Due to similar calculations, it is likely that the FT:CT ratio and RSImod share similar reliability and an almost perfect relationship. Consequently, there may be no requirement to include both variables in CMJ monitoring reports. This study aimed to investigate this by recruiting twenty-five males to perform three CMJs on a force platform across two sessions that were separated by one week. The FT:CT ratio and two calculations of RSImod (based on the jump height from either flight time or take-off velocity) were then calculated using robust methods. The between-day reliability was good-excellent for all of the variables (95% confidence interval range of the coefficient of variation = 2.02–9.22%) with no significant between-day differences noted (p ≥ 0.231). There was an almost perfect positive relationship between the FT:CT ratio and RSImod regardless of the calculation method (r = 0.944–0.947, p < 0.001). As the FT:CT ratio and RSImod yield similar absolute reliability and share 90% of common variance, there is little reason to include both variables in CMJ monitoring reports.
Quantifying the Impacts of Climate Change on Streamflow Dynamics of Two Major Rivers of the Northern Lake Erie Basin in Canada
Authors: Zhang Binbin , Shrestha Narayan Kumar , Daggupati Prasad , Rudra Ramesh , Shukla Rituraj , Kaur Baljeet , Hou Jun
Published: August 2018

This paper focuses on understanding the effects of projected climate change on streamflow dynamics of the Grand and Thames rivers of the Northern Lake Erie (NLE) basin. A soil water assessment tool (SWAT) model is developed, calibrated, and validated in a base-period. The model is able to simulate the monthly streamflow dynamics with ‘Good’ to ‘Very Good’ accuracy. The calibrated and validated model is then subjected with daily bias-corrected future climatic data from the Canadian Regional Climate Model (CanRCM4). Five bias-correction methods and their 12 combinations were evaluated using the Climate Model data for hydrologic modeling (CMhyd). Distribution mapping (DM) performed the best and was used for further analysis. Two future time-periods and two IPCC AR5 representative concentration pathways (RCPs) are considered. Results showed marked temporal and spatial variability in precipitation (−37% to +63%) and temperature (−3 °C to +14 °C) changes, which are reflected in evapotranspiration (−52% to +412%) and soil water storage (−60% to +12%) changes, resulting in heterogeneity in streamflow (−77% to +170%) changes. On average, increases in winter (+11%), and decreases in spring (–33%), summer (−23%), and autumn (−15%) streamflow are expected in future. This is the first work of this kind in the NLE and such marked variability in water resources availability poses considerable challenges to water resources planners and managers.
Product Environmental Footprint (PEF) Pilot Phase—Comparability over Flexibility?
Authors: Bach Vanessa , Lehmann Annekatrin , Görmer Marcel , Finkbeiner Matthias
Published: August 2018

The main goal of the European product environmental footprint (PEF) method is to increase comparability of environmental impacts of products within certain product categories by decreasing flexibility and therefore achieving reproducibility of results. Comparability is supposed to be further increased by developing product category specific rules (PEFCRs). The aim of this paper is to evaluate if the main goal of the PEF method has been achieved. This is done by a comprehensive analysis of the PEF guide, the current PEFCR guide, the developed PEFCRs, as well as the insights gained from participating in the pilot phase. The analysis reveals that the PEF method as well as its implementation in PEFCRs are not able to guarantee fair comparability due to shortcomings related to the (1) definition of product performance; (2) definition of the product category; (3) definition and determination of the representative product; (4) modeling of electricity; (5) requirements for the use of secondary data; (6) circular footprint formula; (7) life cycle impact assessment methods; and (8) approach to prioritize impact categories. For some of these shortcomings, recommendations for improvement are provided. This paper demonstrates that the PEF method has to be further improved to guarantee fair comparability.
Chinese Remainder Theorem-Based Secret Image Sharing with Small-Sized Shadow Images
Authors: Chen Jinrui , Liu Kesheng , Yan Xuehu , Liu Lintao , Zhou Xuan , Tan Longdan
Published: August 2018

Secret image sharing (SIS) with small-sized shadow images has many benefits, such as saving storage space, improving transmission time, and achieving information hiding. When adjacent pixel values in an image are similar to each other, the secret image will be leaked when all random factors of an SIS scheme are utilized for achieving small sizes of shadow images. Most of the studies in this area suffer from an inevitable problem: auxiliary encryption is crucial in ensuring the security of those schemes. In this paper, an SIS scheme with small-sized shadow images based on the Chinese remainder theorem (CRT) is proposed. The size of shadow images can be reduced to nearly 1 / k of the original secret image. By adding random bits to binary representations of the random factors in the CRT, auxiliary encryption is not necessary for this scheme. Additionally, reasonable modifications of the random factors make it possible to incorporate all advantages of the CRT as well, including a ( k , n ) threshold, lossless recovery, and low computation complexity. Analyses and experiments are provided to demonstrate the effectiveness of the proposed scheme.
An Analysis of Best Practice Patterns for Corporate Social Responsibility in Top IT Companies
Authors: Déroche Germain , Penzenstadler Birgit
Published: August 2018

In order to show their compliance with Corporate Social Responsibility (CSR) goals, companies report their “sustainable initiatives” into their CSR reports. However, from small companies to multinational, it is hard to see the real benefits of sustainable strategies’ implementation, since there are actually no general patterns defined which can ensure high impacts on sustainability. Moreover, there are few metrics and process to assess the efficiency of a sustainability strategy, but the different studies made in that field can show different results, this induces a part of uncertainty to evaluate the performance of a sustainable strategy. Therefore, in this paper, we contribute a pattern approach to implementing sustainability in a company. To do that, we performed an analysis of the 25 CSR reports coming from the 25 biggest companies in the IT sector in order to extract sustainability patterns that are provided in an online catalog to (1) give first tracks to companies which would engage in sustainability initiatives and do not really know where to start; and (2) to give an indicator to companies who already have taken up sustainability initiatives and would like to establish an evaluation of it.
The Unfavourable Impact of Street Traffic on Water Distribution Pipelines
Authors: Așchilean Ioan , Iliescu Mihai , Ciont Nicolae , Giurca Ioan
Published: August 2018

This article analyses the relation between the failures that occurred in the water supply network and the road traffic in the city of Cluj-Napoca in Romania. The calculations in this case study were made using the Autodesk Robot Structural Analysis Professional 2011 software. In the case study, the following types of pipes were analysed: steel, gray cast iron, ductile cast iron and high density polyethylene (HDPE). While in most studies only a few sections of pipelines, several types of pipelines and certain mounting depths have been analysed, the case study presented analyses the entire water supply system of a city with a population of 324,576 inhabitants, whose water supply system has a length of 479 km. The results of the research are useful in the design phase of water distribution networks, so depending on the type of pipe material, the minimum depth of installation can be indicated, so as to avoid the failure of the pipes due to road traffic. From this perspective, similar studies could also be carried out regarding the negative influence of road traffic on sewerage networks, gas networks and heating networks.
Effect of Laser Therapy on the Osseointegration of Immediately Loaded Dental Implants in Patients under Vitamin C, Omega-3 and Calcium Therapy
Authors: Mikhail Faten Fawzy , El-Din Mouchira , Ibrahim Tarek , Zekry Khaled , Nemat Amany Hussein , Nasry Sherine
Published: August 2018

BACKGROUND: The use of laser therapy in the biostimulation of bone repair has been growing steadily.AIM: This study aimed to evaluate the radio-densitometric effect of low-intensity laser therapy on the osseointegration of immediately loaded dental implants in patients under vitamin C, omega-3 and calcium therapy.PATIENTS AND METHODS:  A single implant was placed in the mandibular first molar region of twenty patients which were equally divided into two groups. In the non-laser group, the healing phase was left to progress spontaneously without any intervention, while in the laser group it was augmented with low-level laser therapy of wavelength 904 nm in contact mode, continuous wave, 20 mW output power and exposure time 30 sec with a dose 4.7 J/cm2. Patients in both groups were given vitamin C, calcium and omega-3 starting one month preoperatively. Postoperative digital panoramas were taken immediately after surgery, 1.5 months and 6 months postoperatively. Changes in bone density along the bone-implant interface at the mesial, distal and apical sides were assessed using the Digora software.RESULTS: Independent student t-test was used to compare means of variables between the laser and the non-laser group while repeated measures ANOVA was used to compare bone densities at different times for the same group. Significant increased differences were observed at the mesial, distal and apical sides surrounding the implants of both groups per time. However, the rate of increase was significantly higher in the laser group.  The mean difference at the mesial side after 6 months was 21.99 ± 5.48 in the laser group and 14.21 ± 4.95 in the non-laser group, while it read 21.74 ± 3.56 in the laser group and 10.78 ± 3.90 in non-laser group at the distal side and was 18.90 ± 5.91 in the laser group and 10.39 ± 3.49 in non-laser group at the apical side. Significance was recorded at P = 0.004, P = 0.0001, and 0.001 at the mesial, distal and apical sides respectively.CONCLUSION: The low-intensity laser irradiation significantly promoted bone healing and speeded up the osseointegration process emphasising the laser’s biostimulatory effect.
Prescription of Antibiotics for Periodontal Disease among Dentists in the Region of Tirana
Authors: Abazi Besian , Mihani Joana
Published: August 2018

BACKGROUND: Periodontal disease has been and will be a challenge for dentists in the entirety of oral pathologies. To date, there is no data regarding the prescription of antibiotics for periodontitis in the district of Tirana.AIM: Evaluate aspects related to the pattern of prescription of antibiotics among dentists in Tirana region for periodontitis.METHODS: Prescriptions from dental practitioners were collected from 25 pharmacies, randomly selected. The only prescription containing a diagnosis of periodontitis, with at least one antibiotic given, was included in the study. Data analysis was done with SPSS 20.RESULTS: Out of 1159 initial prescriptions, only 314 met the selection criteria. The average age of patients was 39.91 ± 15.21 years. Mean duration of therapies was 5.57 ± 1.5 days. The most common form of prescription was one broad-spectrum antibiotic (74.5%), combined antibiotics therapy (22.3%) and narrow-spectrum antibiotic (3.2%). Combined antibiotics involved the use of Metronidazole with Amoxicillin (12.1%) and Metronidazole with Spiramycin (10.2%). Significant differences in the patterns of prescription were identified in relation with patient age and therapy duration (P < 0.05). No statistical difference was found in the patient’s gender and the typology of the therapy (P > 0.05).CONCLUSIONS: Our study shows prescription characteristics of antibiotics for periodontal disease by dentists in Tirana for the first time. Amoxycillin is the most prescribed antibiotic, followed by amoxicillin with clavulanic acid. We found variation in dosage, frequency and duration for all antibiotics used, and perceptible discrepancies between observed and recommended practice. Guidelines on rational antibiotic use are needed for dental practitioners in Tirana and the Republic of Albania for better management of periodontitis and resistance prevention.
Children’s Social Perception of Peers’ Dento-Facial Condition: A Cross-Sectional Study
Authors: Kotha Sunil Babu , AlMenawi Ayah , AlKhalaf Reem Abdullah , Binhezaim Alhanouf Khalid , AlHarbi Turki Hamdan
Published: August 2018

AIMS: This study aimed to compare the participant’s perceptions about their peers’ dento-facial condition with different incisal appearances (intact, discoloured, fractured, and avulsed incisors).MATERIALS AND METHODS: A cross-sectional study was conducted among schoolchildren of both primary (8-11 years) and secondary (12-14 years) levels. Each participant was asked to judge photographs with one intact and three digitally modified central incisors giving the appearance of a traumatised tooth. Data on perceptions were collected for each condition using 12 attributes (8 positive and 4 negative; scored on a 4 point Likert scale). The positive, negative and total attribute scores were analysed separately by unpaired Student’s t-test. Repeated Measures ANOVA and Bonferroni post hoc analysis was also used.RESULTS: A group of 587 children participated in the study. The perception for intact and traumatised incisors about demographic factors is well appreciated. Among the gender delineation, girls showed a significant difference in judgment between discoloured and fractured incisors. In comparison to intact incisors, positive and total attributable scores were found to be significantly higher (P < 0.001), whereas negative attribute scores were significantly lower (P < 0.001) for traumatised incisors. Pairwise comparison showed high significance (p <0.001) between the intact and traumatised incisor conditions.CONCLUSION: The results demonstrated that visible dental trauma influenced the psychosocial judgment given by children towards their peers. This judgment would, in turn, affect their level of acceptance towards such appearances. Therefore, these conditions ought to be redressed as swiftly as possible.CLINICAL SIGNIFICANCE: The primary purpose of this study was to highlight the psychosocial perceptions of children in judging their peers, regarding not only attractiveness but also intelligence, friendliness, confidence, outgoing nature, etc.
Plagiarism and Ethical Issues
Authors: Montoneri Bernard
Published: August 2018

This chapter discusses the literature on plagiarism and aims at helping readers better understand what plagiarism is, what is at stake, and how to fight intellectual dishonesty. First, it is essential to define plagiarism and to present the historical background related to academic malpractice. Since the advent of the internet, the number of cases of plagiarism has increased exponentially. Many websites overtly encourage acts of cheating and plagiarism, offer or sell programs designed to copy, generate, and even buy assignments and academic papers. The growing number of retracted documents, not only in open access journals but also in journals owned by major publishers, is disturbing. This chapter will notably discuss the rise and thrive of “predatory” publishers, the growth of fake papers, the abuse of fake positive peer review, and the disturbing success of contract cheating. Finally, it should be noted that even though academic malpractice is damaging the reputation of the scientific community, many solutions have been proposed and implemented.