bluuebunny/crossref_metadata_2025 huggingface dataset:
Yield of soy and efficiency of its cultivation under different systems of main tillage and fertilizer
Authors: Kyrylyuk V.P. , Krychkivsky V.M.
Published: March 2023

Aim. To determine the effect of long-term use of various systems of basic tillage and fertilization on the productivity of soybean agrocenoses, the efficiency of its cultivation technologies. The article presents the results of research on the influence of the main soil tillage and fertilization systems on the formation of the soybean crop and indicators of the economic efficiency of its production in the conditions of the Forest-Steppe of Ukraine with the aim of identifying the most effective, adapted to the weather conditions that have developed in recent years. Methods. Research was conducted during 2018–2021 in a stationary two-factor field experiment, which includes 4 alternative systems of the main tillage (shelf, flat-cut, chisel, disk), and two fertilization systems: mineral (background 1) – N60Р60К60; and organo-mineral (background 2) - precursor straw + N10 / t of straw + N30Р30К30 in a short-rotational 4-field short-rotational crop rotation with the following crop rotation: soybean, spring barley, white mustard, winter wheat. Results. The highest soybean yield of 2.43 t/ha was obtained under the chisel system of the main tillage on the background of organic-mineral fertilizer, which exceeded the control (shelf system) by 0.22 t/ha (10%) and was similar to the highest indicator on the background of mineral fertilizer by 0.05 t/ha (2%). All shelf-free systems outperformed the control on the background of organic-mineral fertilizer by 4-10% and on the background of mineral fertilizer by 2-13%. Conclusions. According to indicators of economic efficiency and productivity of soybeans, the chisel system of the main tillage to a depth of 25–27 cm against the background of organic-mineral fertilizer with the leaving of winter wheat straw + N10 per ton of straw and the introduction of mineral fertilizers in the dose of N30Р30K30 turned out to be the most adapted to the weather and climate conditions of recent years and is promising for introduction into production.
Evaluation of collective samples of oil flax by economic valuable and marking signs
Authors: Tymoshenko O.O. , Levchenko O.S. , Romaniuk L.S. , Kondratyuk V.V. , Pyvovar T.M.
Published: March 2023

Aim. Evaluation of promising collection samples of linseed for economically valuable and marker traits to identify the sources of these traits and their further use in the creation of new breeding material. Methods. Field, laboratory, measuring and weighing, mathematical and statistical. The research was conducted in 2019–2021 at the research fields of the Institute of Agriculture, located in the Fastiv district of the Kyiv region. Results. According to the results of the study and evaluation of 17 promising samples of oil flax of different ecological and geographical origin, the best genotypes were selected in the collection nursery for the main economic, valuable and marker characteristics. It was established that the majority of the collection samples belong to early ripening with a duration of the vegetation period of 85 days. The highest weight of 1000 seeds was found in varieties Evrika, Debut (8.74 and 8.44 g) and Vohni Dniprohesu (7.96 g). The maximum seed productivity was characterized by varieties Evrika (237 g/m2) and Legur (231 g/m2), which also had the largest number of seed pods per plant (17.1 pcs.). According to the total length of the stem, the samples were at the level of 41.8–63.3 cm, and according to the technical length of the fiber – 26.2–44.1 cm. The varieties Svitlozir and Aisberh, which have white flower color and pink and white, were characterized by contrasting marker features color of anthers, respectively. The varieties Debut (dark brown) and Svitlozir (yellow) differ in seed color. The average content of oil in the seeds for the entire sample of varieties was 47.7%. The highest oil content was determined for the Rucheek, Nebesny, Zaporizhzhya Bohatyr, and Vodohray samples (48.5–49.1%). According to the results of the analysis of the fatty acid composition of the flax samples, the best genotypes were selected based on the content of palmitic, stearic, oleic, linoleic, and linolenic acids. Conclusions. According to the results of the study, the best collection samples of oil flax were selected, which are sources of economically useful and marker traits: high seed productivity, increased oil content in seeds, early maturity, which will be involved in the hybridization program to create a new source breeding material with a given set of traits. Basic information on the economic and valuable characteristics of oilseed flax was obtained, which can be used in further scientific research.
Innovations as the main factor of agricultural development at the regional level
Authors: Rasevych I.V. , Demydenko O.V.
Published: March 2023

Aim. Identification of modern features of innovative activity in the agricultural sector of the economy of Ukraine on the example of the Cherkasy region. Methods. Sociological, economic, expert, technological, statistical, marketing. Results. In the modern economy of the Cherkasy region, innovations are an effective means of increasing the competitiveness of agricultural enterprises, since their goal is to create new products and enter new markets, inflow of investments and decrease the cost of production. The innovative activity of regional scientific agricultural institutions today is required the intensification of research against the background of increased competition in the market and the wide introduction of Ukrainian products into the world economy. The experience of economically developed countries is showed that the effectiveness of innovative activities and the degree of involvement of commodity producers in the innovation process largely determine the success of entering the world agricultural market and the competitiveness of agricultural commodity producers. This is placed high requirements on the modernization of the domestic agricultural industry and the development, implementation and use of innovations in this area, making it one of the key principles of strategic development. But there are still a large number of unresolved issues regarding the introduction of domestic innovations: low solvency of agricultural enterprises, imperfect support for innovative activities at the state level, high risk when introducing new technologies, lack of qualified specialists in the field of innovation, lack of an established financial mechanism for the innovative development of agricultural enterprises. The most pressing issue is the modification of completed scientific developments into a knowledge-intensive innovative product, as well as its further implementation. Conclusions. Unfortunately, the interaction between science and business in the state is very weak and underdeveloped. That is why a significant number of promising and interesting innovations are not commercialized and agricultural enterprises lose the opportunity for modern innovative development, which is especially important in the conditions of wartime and the post-war period.
Understanding Institutional Life-Cycle and Sustainability of Co-operative Model: A Case Study of CAMPCO, India
Authors: Jyotishi Amalendu , M.G. Deepika
Published: March 2023

Co-operative movement in India has a long-standing contribution in the growth of business, agriculture and allied activities. One such cooperative movement in India is the Central Arecanut and Cocoa Marketing and Processing Co-operative Limited (CAMPCO) which was initiated with a joint cooperation between the states of Karnataka and Kerala to create an organized market structure for the two plantation crops namely Arecanut and Cocoa in the backdrop of falling market price of these crops. CAMPCO is an interesting co-operative movement, worth investigating in terms of its evolution, challenges, growth and diversification. The paper tries to examine the factors responsible for justifying the existence of the Co-operative structure and its sustainability in the context of CAMPCO, using a modified cooperative life-cycle framework.
Customary Law or State Law: The Settlement of Marine Resource Disputes in The Kei Islands Community
Authors: Ratuanak Andreas M.D. , Irianto Sulistyowati , Lestrarini Ratih
Published: March 2023

The people of the Kei Islands have known cases settlement system since the olden days, namely the Customary judiciary, a forum in the Larvul Ngabal customary law system that holds a high authority, which is obeyed by the community and is often the main choice in resolving disputes. With a field study approach, this study aims to explain how the settlement process of natural resources disputes by a “customary judge” in the Kei Islands is still used as a reference by the community. What are the reasons? This study discovered that customary settlement forums are still used to resolve marine resource disputes and deemed to provide a sense of justice. Customary settlements are not only aimed at punishing the perpetrators, but also to restore the impact of the dispute on individual victims, their families and their social environment. This study also discovered that the customary settlements carried out in the Kei Islands have developed from the dated dichotomy and tend to produce hybrid settlement models.
Burials of the Sarmatian Time of the Upper Sula and Upper Psel Basins (Beginning of the 1st Millennium AD)
Authors:   Historical and Cultural Reserve “Bilsk” at the Poltava Regional Council, Priymak Viktor
Published: March 2023

The article is devoted to the region of the upper reaches of the Sula and Psel rivers and adjacent territories. It is proposed to single out the late Scythian region from the 2nd century BC to the 1st—2nd centuries AD in the Upper Sula basin. The Late Scythian, Sarmatian and some (stationary researched) Late Zarubintsy sites have been mapped. The majority of the Sarmatian complexes have not been published, and late Scythian sites have not been sufficiently studied. The mapping of the sites is considered as a preparatory stage for further study of the antiquities of the late Scythians and Sarmatians. The Sarmatian sites of the Left Bank of the Dnieper (2nd century BC — 1st—2nd centuries AD) and the Kharievka type (2nd century BC — first half 1st century AD) are represented by material complexes. Late Scythian and late Zarubintsy antiquities are dominated by in situ finds and objects. There are also stray finds of artifacts. The author believes that further steps in this study will require development of a unified system of chronology, including all, without exception, types of antiquities from the Dnieper’s Left Bank.
Multiple Burials in the Cemeteries of the Chernyakhov-Sântana de Mureş Culture
Authors:   V. N. Karazin Kharkiv National University, Lyubichev Mihail , Schultze Erdmute ,   Eurasian Department of the Germany Archaeological Institut
Published: March 2023

Funerary customs of the Chernyakhov culture are subject have been studied for more than 50 years. But until now, the graves including two or more deceased have never got particular attention. For the area of the Chernyakhov-Sântana de Mureş culture, 13 sites with double or multiple inhumation graves have been detected. Even on graveyards with large scale excavations, the number of multiple inhumations varies from one double/multiple burial to 15. In Târgşor cemetery, this number includes multiple cremation graves too. Therefore, these graves represent a rare phenomenon within the funerary customs of the Chernyakhov-Sântana de Mureş culture. Concerning inhumation burials, there are no connections to special grave constructions, double burials have been found in simple pits, as well as in graves with horizontal shelf, niche or installation made of wood. The grave goods are typical for this culture. The combination of grave construction and inventory of double/multiple burials indicates that the deceased could belong to every social stratum. There is no evidence that the second or third person were buried as companion or even sacrifice for the first deceased. Depending on gender and age of the deceased, other reasons have to be taken into account for the multiple burials: either the presumably simultaneous death of two/three persons, or within a short time interval, for example due to an illness or epidemic disease.
Brooches in the Costume of the Sarmatian Age Population in the Crimean Piedmont and the Great Hungarian Plain
Authors:   Jósa András Museum, Istvánovits Eszter , Kulcsár Valéria ,   University of Szeged, Stoianova Anastasia ,   Institute of Archaeology of Crimea of the Russian Academy of Sciences
Published: March 2023

The article analyzes the methods of use of brooches by the population of two faraway regions of the Sarmatian culture: Crimean Piedmont and Great Hungarian Plain. The study focuses on the types of brooches, their amount and situation in the burials of different age-sex groups. We succeeded in determining common consistent patterns and special features in the use of brooches by the inhabitants of the two regions, where brooches of different constructive types were in fashion. In the course of the Roman Age, the predominant costume included one brooch that fastened humeral outwear, most probably, a jacket or a robe. Despite of the significant similarity in the traditions of applying the brooches, it is doubtful whether we can speak about direct contracts or mutual influences of the populations of the two distant regions, because this costume model dominated on the whole territory of the Sarmatian world.
Assessment of Anxiety and Burden on caregivers for haemodialysis patients in southern Punjab, Pakistan
Authors: NAZİR Shabnam , RAZA Hina , NİSAR Memoona , RASHİD Zermina , SHAMİM Rahat , ALAM Bushra , KHAN Amjad
Published: March 2023

The aim of present study is to assess anxiety and depression experienced by unpaid caregivers of chronic haemodialysis patients suffering from end-stage renal failure (ESRF). The evaluation of factors influencing anxiety and depression and care-giving burden was performed. In the present study, non-paid primary caregivers (218 study participants) of patients with ESRF receiving haemodialysis, who were providing care (minimum 6 months and up to 5 years) were interviewed by using Aga Khan University Anxiety and Depression Scale (AKUADS) and the carer’s burden of peritoneal dialysis patients (CSCDP) questionnaire. According to the scoring of AKUADS, 90.4% caregivers were found to be experiencing significant anxiety and depression. From assessment of demographic factors collected using the AKUAD scale, it was found that female gender was more in number (44%), wedded (72.01%), with a mean life span of 38.5 ± 2 (SE) years, and having monthly income below average. The main relationships of caregivers with patients, was life partners (38%) and parents (18.2%). The highest depression levels were found in mothers as attendants (67%), caregivers of age less than 30 years (22 %) and caregivers of elderly patients (87%). The outcome of this study has revealed a need to plan policies to support unpaid caregivers as well as the patients
The Relative Bioavailability Study of Two Cefdinir Formulations in Healthy Males Under Fasting Conditions
Authors: YERLİKAYA Fırat , ARSLAN Aslihan , ATİK Özlem , KOZAN Seda , PARLAK Ahmet , ÖZEL KARATAŞ Meltem , SAĞLAM Onursal , AYTAÇ Sevim Peri
Published: March 2023

A new oral formulation of cefdinir, Cefdinir 600 mg Tablets has been developed and in this study, its relative bioavailability has been compared with another oral solid dosage form, Cefdinir 300 mg Capsules, which is already on the market. An open-label, randomized, two-period, cross-over relative bioavailability study has been conducted with healthy males under fasting conditions in compliance with Good Clinical Practice (GCP) principles. A single dose of the novel tablet formulation of 600 mg cefdinir has been compared to two doses of Cefdinir 300 mg Capsules (two capsules at once) in terms of their pharmacokinetic properties. The comparison study was performed as a single-center clinical study, and blood samples of the participants were withdrawn at specified time points, before and after dosing. The plasma concentrations and pharmacokinetic properties of two cefdinir formulations were assessed from the collected samples by using a validated LC-MS/MS analytical method. The relative bioavailability of the new formulation has been shown and both products were introduced as safe.
Caffeine May Improve the Chemotherapeutic Effect of Docetaxel by Inducing UPR and Autophagy in Breast Cancer Cells
Authors: ERZURUMLU Yalçın , ÇATAKLI Deniz , DOĞAN Hatice Kübra , AYDOĞDU Esra
Published: March 2023

Breast cancer is the most frequently diagnosed cancer type among women. Chemotherapeutics are widely used for breast cancer treatment but acquired drug resistance is the main reason that limits their efficacy. Therefore, there is a continuing need for more effective treatment approaches with fewer side effects. One of the naturally occurring xanthine in coffee beans, caffeine is the most commonly used psychoactive substance worldwide. Numerous studies have drawn attention to the health benefits of coffee intake including decrement in risk of heart disease and risk of some cancers. Docetaxel is a second-generation antineoplastic agent of the taxane family and is widely used in the treatment of numerous cancers such as breast cancer. Herein, we evaluate the effect of caffeine and its combination with docetaxel on MCF-7 breast cancer cells. To test the effect of caffeine and its combination with docetaxel, we evaluate the autophagy, ubiquitin-proteasome system, unfolded protein response signaling and apoptosis-related protein levels were examined by immunoblotting. Cell viability was measured by WST-1 method. Morphological alterations in cells were evaluated in microscopical examinations. We found that caffeine remarkably induced UPR signaling, accelerated autophagic flux, and UPS-dependent protein turnover. Co-administration of caffeine and docetaxel strongly diminished the viability of MCF-7 cells by expanding the cytotoxic effect of docetaxel through accelerating the UPS-dependent protein turnover, induction of autophagy and apoptotic protein levels in a manner dose-dependently. Our results suggest that caffeine supplementation with docetaxel may expand the chemotherapeutic efficiency of docetaxel in breast cancer.
Afrodescendência
Authors: BOAKARI Francis
Published: March 2023

Arrancar dos escombros as narrativas valiosas de nós mesmas, pessoas afrodescendentes. Esta obra é uma maneira de viabilizar esta ação. Mas, também, de mostrar as riquezas e os desafios de sermos descendentes dos primeiros seres humanos da humanidade e de suas diásporas históricas como múltiplas, transitórias, duradouras, intercambiantes, diversas e cotidianas.
Planung und Gestaltung erholsamer Landschaften im Kanton Zug
Authors: Brennecke Martina
Published: March 2023

Das Bedürfnis nach Naherholung ist nicht erst mit der Corona-Pandemie in den Fokus gerückt, sondern seit Jahren aufgrund der stetig steigenden Bevölkerungszahlen ein Thema. Nicht von ungefähr spricht man vom Erholungsdruck auf die Landschaft und weniger von den erholsamen Landschaften. Attraktive Landschaften werden durch Erholungssuchende (über)strapaziert, was nach Regulierung ruft und nach der Verlagerung von Freizeitnutzungen in weniger empfindliche Naturräume. Die Planung oder gar Gestaltung erholsamer Landschaften ist eine enorme Herausforderung, nicht zuletzt, weil sie unterschiedlichste Nutzungen auf zumeist privatem Grundeigentum ermöglichen soll. Entsprechend aufwendig sind die Planungsprozesse, was am konkreten Beispiel eines Naherholungsgebietes in der Stadt Zug aufgezeigt werden soll.
PENGATURAN INVESTASI UNTUK MEWUJUDKAN KESEJAHTERAAN MASYARAKAT TEMPATAN AKIBAT DAMPAK PENGEBORAN MINYAK BLOK ROKAN (RIAU, ROKAN HILIR)
Authors: Adinda Fadhel
Published: March 2023

Berdasarkan amanat dari pada pembukaan Undang-Undang Dasar 1945 pada alinea ke-empat, negara wajib mengusahakan peningkatan kesejahteraan masyarakat Indonesia. Investasi merupakan salah satu cara dalam mengupayakan peningkatan taraf kesejahteraan masyarakat Indonesia. Investasi tidak hanya menguntungkan para investor yang memiliki modal saja, akan tetapi berdampak kepada masyarakat sekitar tempat dimana bidang usaha investor dijalankan. Akan tetapi ini semua akan terlaksana dengan baik apabila pengaturan mengenai investasi sudah mencakup keinginan serta kebutuhana masyarakat saat ini, karena didalam perkembangannya hukum haruslah bersifat dinamis demi mendapatkan tujuan awal yaitu meningkatkan taraf kesejahteraan hajat hidup orang banyak. Penelitian ini menggunakan metode penelitian hukum normative, bersumber dari peraturan perundang-undangan, buku, jurnal dan setiap hal yang menunjang penelitian ini.
IKTIKAD BAIK DALAM PELAKSANAAN RE-STRUKTURISASI KREDIT
Authors: Admiral Admiral
Published: March 2023

Abstrak
Pada prinsipnya peneilitian ini bertujuan untuk mengetahui serta memahami terwujudnya iktikad baik dalam pelaksanaan restrukturisasi kredit pada masa pandemi Covid-19. Iktikad baik itu sendiri merupakan suatu tindakan serta niatan yang diwujudkan serta dituangkan melalui tindakan-tindakan yang responsive, positif, dan bertanggung jawab, sehingga seluruh tujuan awal dari kredit antara para pihak dapat tercapai dan terlaksana dengan baik. Metode yang digunakan dalam penelitian ini yaitu yuridis normative yang memfokuskan terhadap hukum positif berdasarkan peraturan-peraturan, jurnal-jurnal, buku-buku yang secara langsung berkaitan dengan penelitian ini. Hasil kajian penelitian ini diharapkan berguna untuk mencerdaskan kehidupan bangsa serta berdampak langsung terhadap dunia perkreditan.
Abstract
In principle, this research aims to identify and understand the realization of good faith in the implementation of credit restructuring during the Covid-19 pandemic. Good faith itself is an action and intention that is realized and poured through responsive, positive, and responsible actions, so that all the initial goals of credit between the parties can be achieved and carried out properly. The method used in this research is normative juridical which focuses on positive law based on regulations, journals, books that are directly related to this research. The results of this research study are expected to be useful for the intellectual life of the nation and have a direct impact on the world of credit.
AKIBAT HUKUM DALAM PEMBIAYAAN KONSUMEN YANG TIDAK DISERTAI DENGAN PERJANJIAN FIDUSIA
Authors: Erlina Erlina , Idris Zulherman , Zaharnika R. Febrina Andarina
Published: March 2023

Undang-Undang Nomor 42 Tahun 1999 tentang Jaminan fidusia, menyatakan bahwa setiap pembebanan objek jaminan dengan fidusia dilakukan dengan sebuah Akta Notaris, setelah itu akta tersebut didaftarkan kebagian pendaftaran fidusia di kantor Departemen Hukum dan Hak Asasi Manusia untuk mendapatkan sertifikat Fidusia. Terbitnya sertifikat fidusia akan mendapat hak-hak kebendaan bagi penerima fidusia dalam hal ini perusahaan pembiayaan, sehingga penerima fidusia akan diuntungkan dengan mendapatkan hak-hak kebendaan, seperti kemutlakan dalam kepemilikan objek jaminan, hak untuk mengikuti kemanapun benda berada serta didahulukan pemenuhan piutangnya. Penelitian ini bertujuan untuk mengetahui akibat hukum dalam pembiayaan konsumen yang tidak disertai dengan perjanjian fidusia. Hasil penelitian ini menunjukan bahwa Pembiayaan Konsumen yang tidak disertai dengan perjanjian fidusia dalam bentuk Akta Notaris serta tidak mendaftarkan kebagian pendaftaran fidusia. Dengan demikian berakibat tidak mendapatkan perlindungan hukum bagi para pihak, khususnya bagi pihak perusahaan pembiayaan dalam bentuk penguasaan objek jaminan.
TINJAUAN TENTANG PERAN NOTARIS DALAM PENGESAHAN PERJANJIAN PERKAWINAN DI INDONESIA PASCA PUTUSAN MAHKAMAH KONSTITUSI NOMOR 69/PUU-XIII/2015
Authors: Ridhanti Anissa , Anshary Abdul Hadi
Published: March 2023

Perjanjian kawin dibuat dalam bentuk tertulis dan sebelum dilangsungkannya perkawinan atau diberlakukan sejak perkawinan berlangsung. Perjanjian ini dilekatkan pada akta nikah yang merupakan bagian dari surat nikah. Perjanjian dibuat atas persetujuan atau kehendak bersama secara tertulis dan disahkan oleh pegawai catatan sipil, namun perjanjian ini tidak boleh bertentangan dengan hukum, agama dan kesusilaan. Perjanjian kawin dibuat dalam bentuk akta, naik akta di bawah tangan maupun akta authentik. Pencatatan perjanjian perkawinan kedalam akta perkawinan tersebut dinilai penting, karena pasangan suami istri selama masa perkawinannya pastilah melakukan suatu perbuatan hukum dengan pihak ketiga, apabila tidak dilakukan pencatatan, maka perjanjian perkawinan tersebut hanya mengikat bagi para pihak yang membuatnya. Metode yang digunakan yaitu pendekatan pendekatan hukum normatif atau pendekatan perundang-undangan dan sifat penelitiannya termasuk dalam penelitian normative. Minimnya minat masyarakat untuk membuat perjanjian perkawinan disebabkan berbagai hal, misalkan belum jelasnya aturan hukum yang mengatur tentang hal ini. Masyarakat juga masih mengalami kesulitan ketika membuat perjanjian perkawinan apakah harus ke Notaris atau ke Disdukcapil. Ketidaktahuan ini yang menjadi salah satu penyebab kurangnya minat masyarakat untuk membuat perjanjian perkawinan tersebut.
Construção e Evidências Psicométricas da Escala de Gratidão
Authors: Porto Noronha Ana Paula , Santina Murgo Camélia , De Oliveira Barros Leonardo , Soares Sena Bárbara Cristina , Santos de Souza Leonardo
Published: March 2023

Objetivamos construir e analisar as propriedades psicométricas de um instrumento para avaliar a gratidão em formato de julgamento situacional. Após a análise de juízes e estudo piloto, houve a exclusão de 6 itens dos 15 elaborados inicialmente. No estudo de busca de evidência de validade por meio da estrutura interna participaram 514 pessoas, sendo 56% do sexo feminino, com idades entre 14 e 72 anos, que responderam à Escala de Gratidão, Escala de Afetos, Escala de Vitalidade e a Escala de Satisfação com a Vida. A análise fatorial exploratória indicou uma estrutura unidimensional composta por 9 itens. As mulheres apresentaram as maiores médias quando comparadas aos homens, tanto no julgamento como na autoavaliação da gratidão. A gratidão apresentou correlação, em sentido positivo com magnitude fraca, apenas com a vitalidade. Os dados indicaram evidências de validade com base no conteúdo do teste, consistência interna e na relação com variáveis externas para a Escala de Gratidão.
Vulnerability to child sexual abuse: NOABS tool
Authors: Bravo García Leslie , Losada Analia Veronica
Published: March 2023

Background: The prevalence of child sexual abuse shows a result of 19% in females and 8% in males. Objective: The main aim of this study, is to identify the level of vulnerability and risk of sexual abuse in children between 6 to 13 years old with the NOABS tool. Participants and Setting: 684 children between the ages 6 and 13 from the Simón Araujo school in Sucre, Colombia. Methodology: The methodology used in this study has a descriptive approach and data was analyzed with a quantitative strategy. Results: After analyzing the data, it shows a 5.3 % high vulnerability (VA), (VA) female (F) 4.3 %, 6.5 % male (M), (VA) family context 16.1 %, social 14.9 %, school 8.2 %. Conclusions: Other researches allow to compare these results in order to have a clear idea about the levels of vulnerability and risk of abuse validating the NOABS game.
“Se não posso dançar, não é minha revolução”: autocuidado e hapticalidade como práticas políticas
Authors: Guzzo Marina Souza Lobo
Published: March 2023

Este artigo pretende cartografar e articular duas práticas em torno do corpo e do cuidado na área da saúde: o autocuidado e a hapticalidade. Essas duas práticas e perspectivas entrelaçam-se na frase emblemática atribuída à feminista Emma Goldman “se não posso dançar, não é minha revolução”. A partir das perspectivas dos gestos menores de Erin Manning, a dança é apresentada como encontro que possibilita e estimula esses conhecimentos pouco abordados nas formações da área da saúde. Alegria, poesia e conhecimento do próprio corpo e do corpo do outro, assim como atenção, respiração e sustentação são eixos para escutar e atuar no mundo. Uma dança menor, que entende o corpo como processo de invenção, criação e espaço de experiência. Esse exercício de escrita se propõe a aproximar cuidado e luta, numa possibilidade de transformação, revolução e ética na área da saúde.
Mudança nos Conflitos Interpessoais de uma Paciente Borderline em Psicoterapia Psicodinâmica
Authors: Castro Flavia Ciane Assmann , Feijo Luan Paris , Strassburger Betina Capobianco , Bittencourt Aline Álvares , Serralta Fernanda Barcellos
Published: March 2023

Pacientes com Transtorno de personalidade borderline (TPB) possuem características relacionais disfuncionais que impactam seus relacionamentos interpessoais. O objetivo foi o de descrever os padrões relacionais de conflito de uma paciente com TPB da psicoterapia psicodinâmica. Trata-se de um estudo de caso sistemático. Utilizou-se o método Tema Central de Conflito nos Relacionamentos (CCRT). Juízes independentes analisaram as gravações e transcrições das sessões do tratamento. A análise foi realizada com base na frequência dos componentes do CCRT. Os resultados indicam que o conflito central da paciente se mantém o mesmo ao longo do tempo, assim como seu desejo principal, mas há uma mudança significativa nas respostas, ou seja, na forma como a paciente interage em seus relacionamentos, apresentando maior flexibilidade para lidar com os outros e os percebendo mais positivamente. O estudo fornece subsídios aos psicoterapeutas para identificar e trabalhar o padrão de relacionamento disfuncional de pacientes com TPB.
The Role of The Work Environment as an Intervening Variable on the Relationship of Organizational Culture and Work Discipline on Employee Performance in the Office of the Head of Village Kesiman Kertalangu
Authors:   Warmadewa University Master of Management Study Program, Putra Pratama I Kadek Surya , Amerta I Made Suniastha ,   Warmadewa University Master of Management Study Program, Putra Ida Bagus Udayana ,   Warmadewa University Master of Management Study Program
Published: March 2023

This study was done in order to help develop and examine the role of the work environment as an variable of intervening for the effect of organizational culture and work discipline toward performance of employee at the Kesiman Kertalangu Village Office. This study used a questionnaire method that was carried out systematically regarded to the research objectives. The subject were the amount of employees of the Kesiman Kertalangu Village Office with 37 respondents. This research applied a Likert scale on purpose to help measure the variables and also to conduct validity and reliability test for the variables. This study uses PLS-based SEM as an analytical tool. The results showed that organizational culture gave such a positive and also significant influence toward performance. Organizational culture revealed a positive and also significant effect toward work environment. Work discipline gives a positive and also significant influence toward performance. Work discipline gives a positive and significant influence toward work environment. The environment of work gives a positive and also significant influence toward performance. Job satisfaction is a partial mediation of the of the organizational culture toward performance. The environment of work partially mediates the effect between work discipline and also performance .
Evaluation of Factors Affecting Antiretroviral Treatment Changes in HIVPositive Patients in a University Hospital
Authors: Çakır Yasemin , İnce Nevin , Çalışkan Emel , Tunca Bekir , Yekenkurul Dilek
Published: March 2023

Introduction: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is the leading cause of death from infectious diseases in the world. With the antiretroviral treatments developed over the years, viral replication is suppressed even though the disease cannot be cured yet. However, antiretroviral therapy (ART), like all drugs, has brought with it undesirable side effects as well as positive effects. In addition, demographic characteristics, accompanying comorbidities, organ dysfunctions, viral load, CD4 T lymphocyte count, ART resistance status, coinfections, pregnancy are also effective factors in the initial ART decision and change. In this study, we aimed to show the treatment status of HIV-positive patients followed in the infectious diseases outpatient clinic of our hospital and to determine the factors that affect ART change. Materials and Methods: Demographic data of HIV-positive patients followed in the infectious diseases outpatient clinic between January 2016 and May 2021, HIV-RNA and CD4 T lymphocyte results obtained before and after antiretroviral therapy, and the reasons for changing treatment were evaluated retrospectively. Results: The mean age of the patients included in the study was 40.0 ± 13.9 (min: 20-max: 76), and 16 (18%) were female and 71 (82%) were male. Treatment was changed in 32% of the patients. Changes were made due to drug-related side effects in 43%, patient-related reasons (such as single tablet request, non-compliance with treatment) in 25%, and virological unresponsiveness in 18% of patients who underwent treatment change. The most common cause of drug changes due to side effects was hyperlipidemia. The treatment regimens that changed the initial treatment were most frequently TDF/FTC/LPV/r and TDF/FTC/EFV, respectively. Conclusion: As a result of our study, we found that the most common cause of ART change in HIV-positive patients in our hospital was drug-related side effects, and patient non-compliance was the second most common. It is important to know the factors that cause these changes in advance and to make choices accordingly when starting the treatment, in order to increase patient compliance and facilitate follow-up.
The Use of Probiotics in the Treatment and Prophylaxis of Various Diseases in Türkiye: A Systematic Review
Authors: Kahraman Kılbaş Elmas Pınar , Altındiş Mustafa
Published: March 2023

The aim of this study is to analyze the available information on the use of probiotics containing different microorganisms, singly or in combination, in order to investigate the effect of probiotics on the treatment, prophylaxis and microbiota of various diseases. In addition to Pubmed, Google Scholar, SCOPUS, EMBASE, Cochrane Library of Systematic Reviews, CINAHL, AMED, Turkish Medline electronic databases, the gray literature was searched to cover the years 2004-2021. Randomized controlled studies (RCTs) included in the specified selection criteria were brought together. RCTs were evaluated using the Cochrane risk of bias tool. Of the 32 RCTs included in total, only yeast (Saccharomyces spp.) was administered in fourteen, only Lactobacillus spp. in six, Bifidobacterium spp. only in four, and probiotic supplementation containing more than one bacterial strain in six. Only 10/32 of the included studies fully reported the probiotic strain, and 22/32 reported only at the species level. In all nine studies using probiotics for the treatment of diarrhea, probiotics were reported to shorten the duration of diarrhea and length of hospital stay. Four of the five studies reporting the use of probiotics in the treatment of necrotizing enterocolitis reported that probiotics were not effective in reducing the incidence of necrotizing enterocolitis, but could improve nutritional tolerance. In two of the four RCTs investigating the use of probiotics in the treatment of Helicobacter pylori infection, it was stated that the side effects associated with eradication therapy decreased. In both studies conducted for prophylaxis, it was reported that probiotics prevent antibiotic-associated diarrhea. This study shows that probiotics have positive results for the treatment indications and prophylaxis of various diseases. For the sustainability of these health benefits and the safe administration of probiotics, more research is needed that includes strain information and side effect reports
Evaluation of Antibody Response and Side Effects Related to the Number of Inactive and mRNA Vaccine Doses Against COVID-19 in Healthcare Workers
Authors: Bozok Taylan , Gülbudak Harun , Ülger Seda Tezcan , Aslan Gönül
Published: March 2023

Introduction: Studies are showing that a high antibody response increases the protection against variants in the fight against the COVID-19 pandemic. In this study, we aimed to investigate the relationship between antibody response and side effects based on the number of doses administered to healthcare workers who were vaccinated against COVID-19. Materials and Methods: Healthcare workers, who were vaccinated with two doses of BNT162b2 (Group 1), a single dose of BNT162b2 following two doses of CoronaVac (Group 2), or two doses of BNT162b2 following two doses of CoronaVac (Group 3), were randomly assigned to this study. Serum samples were taken from the participants 30 ± 2 days after the last vaccination date, and the SARSCoV-2 anti-spike S1 RBD IgG test was administered to these samples. A questionnaire was conducted detailing the demographics of the patients as well as their post-vaccination complaints. The results were analyzed statistically. Analysis results with a p-value of <0.05 were considered significant. Results: A total of 179 healthcare professionals with a mean age of 41.7 ± 10.6 years were included in our study. Of the studied samples, 95.5% (n= 171) were interpreted as anti-spike S1 RBD IgG seropositive. Positivity rates and mean antibody levels were 93.2%, 95.9%, 97.8%, and 107.4 ± 117.1, 152.7 ± 108.5, 201.4 ± 114.9 (AU/mL) for Group 1, Group 2, and Group 3, respectively (p< 0.05). In general, no significant differences in antibody response were seen based on gender or age. However, a significant correlation was found between the occurrence of vaccine-related side effects and antibody titer (p< 0.001). The most common side effect was pain in the area where the vaccine was administered, with a rate of 77.4% (n= 48). More vaccine-related side effects were reported in participants under the age of 40 and in female healthcare workers. Conclusion: We believe that booster doses are effective for increasing the immune response and thus protecting against COVID-19. More extensive research should be conducted to confirm the link between the occurrence of vaccine-related side effects and antibody titer. Furthermore, studies on the safety of increasing the number of vaccine doses are required.
Clinical Features and Risk Factors for Mortality in Patients with Stenotrophomonas maltophilia Infection
Authors: Çopur Betül , Sürme Serkan , Tunçer Gülşah , Karaduman Rümeysa Gülistan , Erdoğan Hatice , Pehlivanoğlu Filiz , Şengöz Gönül , Yıldırım Mustafa
Published: March 2023

Introduction: It is important to know the risk factors for death in reducing mortality in patients with Stenotrophomonas maltophilia infections. The purpose of this study was to examine the risk factors associated with mortality in hospitalized patients with S. maltophilia infections. Materials and Methods: Patients with S. maltophilia infections aged 18 years and older who were hospitalized in Haseki Research and Training between January 1, 2017, and April 30, 2022, were included in the study. The patients were divided into two groups, non-survivors and survivors, and the clinical features and laboratory parameters of the groups were compared. Mortality risk factors were analyzed by logistic and Cox regression analyses. Results: A total of 75 patients with S. maltophilia infections were included. The mortality rate was 38.6% (n= 29). Advanced age (OR= 1.05, 95% CI= 1.012-1.085, p= 0.009), COVID-19 pneumonia (OR= 9.52, 95% CI= 1.255-72.223, p= 0.029), and presence of central venous catheter (CVC) (OR= 18.25, 95% CI= 2.187-152.323, p= 0.007) were risk factors for death. Conclusion: Physicians should be aware of the potential risk of S. maltophilia infections for mortality, particularly in patients with predefined risk factors such as advanced age, the presence of CVC, and COVID-19. Performing CVC care in accordance with infection prevention and control measures and timely removal of CVC may be beneficial in reducing deaths due to S. maltophilia infection.
Assessment of the Association of Vaginal Infection with Atypical Pap-smear Results
Authors: Kırlangıç Mehmet Mete , Sade Osman Sertaç , Arıcı Halıcı Belfin Nur
Published: March 2023

Introduction: This study aims to evaluate the frequency of infectious agents in Pap-smear results and their association with pathological results. Materials and Methods: This retrospective study was conducted by evaluating the smear results between January 1, 2021 and December 31, 2021 at the Tuzla State Hospital. Smear results were classified according to the Bethesda system [normal, atypical squamous cells of undetermined significance (ASC-US), atypical squamous cells-high-grade (ASC-H), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), atypical glandular cells (AGC) carcinoma]. In addition, vaginitis agents (Trichomonas vaginalis, Gardnerella vaginalis, Candida spp., Actinomyces spp.) found in the report were also recorded separately. Results: In the study, as a result of the evaluation of 4708 smear results, a vaginal infectious agent was found in 675 patients (16.55%). G. vaginalis was observed most frequently in 322 patients (7.9%), and the Candida spp. was observed in 298 patients (7.3%). Actinomyces spp. was observed in eight patients and T. vaginalis was observed in two patients. Pathology results were normal in 4129 (87.7%) according to the 2014 Bethesda system. Five hundred and fifty (11.68%) of them were ASC-US, nine (0.19%) ASC-H, 17 (0.36%) LSIL, and three (0.06%) were reported as HSIL. G. vaginalis was accompanied in 29 of the ASC-US results, and Candida spp. accompanied 10. Candida spp. was observed in 2 of 9 patients diagnosed with ASC-H, and G. vaginalis was observed in one of them. G. vaginalis was found in 1 of 17 patients diagnosed with LSIL, and no infection was found in three patients diagnosed with HSIL. Conclusion: Routine Pap-smear examination is essential for identifying cervicovaginal infectious agents as well as cervical pathologies.
Coexistence of Ophthalmic Shingles and COVID-19 in a Patient Who Applied with Encephalitis Clinic
Authors: Aydın Emsal , Ataş Emrullah , Çetin Sinan , Şahin Ahmet Melih , Şenel İlknur , Sağlam Mustafa , Yetkin Meltem Arzu
Published: March 2023

Varicella zoster virus (VZV) is a member of the herpes virus family and is the causative agent of chickenpox and shingles. While chickenpox, which is the primary infection, is mostly seen in childhood, shingles is located latently in the dorsal root sensory ganglia and cranial nerve ganglia, causing recurrent attacks in adulthood. Shingles may rarely present with neurological complications such as encephalitis. Many diseases are seen in the coexistence of Coronavirus disease-2019 (COVID-19) due to the pandemic. In this case report, it was aimed to draw attention to the ophthalmic varicella zoster virus infection with a different clinical onset accompanied by COVID-19 who presented with the clinic of encephalitis.
Psychophysiological Response to Social Feedback using the Chatroom Interact Task in Undergraduate Students
Authors: Birk Samantha L. , Mennies Rebekah J. , Guerra-Guzman Karina , Aunapu Darien , Olino Thomas M.
Published: March 2023

Receipt of both positive and negative social feedback is associated with psychophysiological responses, and such responses vary based on levels of internalizing symptoms and associated cognitive constructs. However, research examining the relationship between physiological response to social feedback and internalizing symptoms is mixed, and there is a need to develop salient tasks to assess responses to social feedback. This paper reports on two studies that examined physiological response to social feedback in undergraduate students using the Chatroom Interact Task (CIT). We also explored associations between physiological response to social feedback and internalizing symptoms and associated constructs. Participants were 48 (35 female; Study 1) and 65 (55 female; Study 2) undergraduate students. Participants completed self-report questionnaires of internalizing symptoms and associated cognitive constructs. They also completed the CIT to assess response to acceptance and rejection, while physiological data, including electrocardiogram and respiration to derive respiratory sinus arrhythmia (RSA), were acquired. Results across both studies were largely consistent. There were significant differences in RSA during the questionnaire phase and the neutral and acceptance/rejection phases of the CIT. There were no differences between RSA during acceptance and rejection phases. Internalizing symptoms and associated constructs were not related to differences in RSA. The current study indicates questionable validity for the use of the CIT to elicit heightened physiological responses to social feedback in undergraduates and suggests important considerations for the future study of responses to social feedback and the design of associated tasks.
Parkinson's disease gene therapy: a comparative effectiveness review of completed clinical trials in terms of their possible implementation in treatment
Authors: Kozłowska Marta , Kotarba Szymon , Tambor Jakub , Winiarski Mateusz , Moczulska Hanna , Pietrusiński Michał , Borowiec Maciej
Published: March 2023

Background: Parkinsons disease (PD) is a neurodegenerative disease in which dopaminergic neurons are damaged, and Lewy bodies accumulate in the brain, leading to both motor and non-motor symptoms. Currently, no treatment is available to slow down or reverse disease progression. The need to find new solutions has prompted research interest in gene therapy. Aim of the study: The purpose of this review is to analyze a selection of completed clinical trials on gene therapy in PD and their possible implementation in treatment. Material and Methods: Clinical trials were selected from the ClinicalTrials.gov database using the following search criteria: Parkinsons disease, gene therapy, and completed status. Trials that were ongoing, terminated, preclinical, or with different research subjects were excluded. PubMed and Google Scholar databases were also searched for neuropathology, symptoms, and treatment recommendations for PD. The results of reviewed clinical trials have been checked in terms of the efficacy and safety of the investigated therapies in the treatment of PD. Results: We analyzed 7 completed clinical trials, namely VY-AADC01 (NCT01973543), AAV-GAD (NCT00195143), ProSavin (NCT00627588), AAV2-GDNF (NCT01621581), CERE-120 (NCT00252850), VY-AADC01 (NCT03065192), and CERE-120 (NCT00985517) with a total of 152 patients. Five of the studies had published results and four of these five had satisfactory results. VY-AADC01, AAV-GAD, and CERE-120 were found to be safe and potentially effective in the treatment of PD, while ProSavin demonstrated insufficient effectiveness. Conclusions: There is limited available data regarding completed clinical trials for PD gene therapy, with a small number of patients, making it difficult to give a final statement on the possibility of using gene therapy to treat PD. However, the clinical trials reviewed herein show promising results with the potential to revolutionize the treatment of PD.