bluuebunny/crossref_metadata_2025 huggingface dataset:
Are We Doing the Right Thing?
Authors: Trošt Bobić Tatjana , Bobić Goran , Mohorović Andrea , Novak Dario
Published: December 2021

In the Croatian high school system, students can attend the same school, but, based on their cognitive abilities, they may be assigned to a regular or an adapted study program. The basic assumption is that students differ predominantly based on their cognitive rather than motor abilities. Therefore, their motor abilities are evaluated through the same battery of motor tests. The aim of this study is to evaluate the metric characteristics of the tests used to evaluate motor abilities of high school students enrolled in an adapted study program, and to compare their results with the results of students engaged in the standard curriculum. The sample consisted of 28 high school students, 14 students in the adapted teaching program (experimental group P) and 14 students in the regular teaching program (control group R). The motor tests were used to assess their muscular endurance, explosive strength, coordination, and flexibility. Normality of distribution was checked by using the Kolmogorov–Smirnov test (KS), while the data processing also included factor analysis, the intraclass correlation coefficient and the t-test for independent samples. The level of statistical significance was set at p<0.05. The obtained data confirmed the homogeneity, sensitivity, and factorial validity of the tests. The results of the t-test for independent samples clearly showed a difference between the arithmetic means of the groups. The students of the R group had better results in all tests than those of the P group. The results suggest the possibility of a significantly different level of motor abilities between high school students attending regular schools according to an adapted or standard study program. All together this points to the need of an individual interpretation of a student’s results rather than a comparison with the set standards. Also, the validation of customized motor tests for a specific population should be considered.
Attitudes of Wannabe Kinesiology Students about School Subjects, School in General and Extracurricular Learning
Authors: Milovuković Saša , Sivrić Hrvoje
Published: December 2021

The aim of this research was to determine and explain the attitudes of wannabe students of kinesiology regarding how much they like each school subject, school in general and extracurricular learning. The answers in the questionnaire were given on a semantic differential scale from 1 (100% repulsive to me) to 5 (I adore it). The study involved 63 wannabe kinesiology students who in 2021 actively prepared for the entrance exam at the Croatian Faculties of Kinesiology. The average age of the respondents was M=18.83±1.33, of which 25 girls and 38 boys. The average rating of all school subjects was M=3.14. The highest rated subject was expectedly Physical Education, but the second-best rated subject (geography) had an average rating of M=3.57. Significant difference between the rating of each school subject from the average of all school subjects was noticed in chemistry, physics and mathematics (on a negative pole compared to the average) and geography on the positive pole, with a medium to large effect size regarding the difference between arithmetic means. Extracurricular learning was almost zero correlated with all other independent variables. We can conclude that wannabe kinesiology students (aligned with other high school graduates) are not fond of school subjects, nor school in general, but this research shows they do love to learn new things not related to school, so teachers/professors might consider including extracurricular material in teaching to make prescribed material more interesting.
Knockdown of vps54 aggravates tamoxifen-induced cytotoxicity in fission yeast
Authors: Lee Sol , Nam Miyoung , Lee Ah-Reum , Baek Seung-Tae , Kim Min Jung , Kim Ju Seong , Kong Andrew Hyunsoo , Lee Minho , Lee Sook-Jeong , Kim Seon-Young , Kim Dong-Uk , Hoe Kwang-Lae
Published: December 2021

Tamoxifen (TAM) is an anticancer drug used to treat estrogen receptor (ER)‒positive breast cancer. However, its ER-independent cytotoxic and antifungal activities have prompted debates on its mechanism of action. To achieve a better understanding of the ER-independent antifungal action mechanisms of TAM, we systematically identified TAM-sensitive genes through microarray screening of the heterozygous gene deletion library in fission yeast (Schizosaccharomyces pombe). Secondary confirmation was followed by a spotting assay, finally yielding 13 TAM-sensitive genes under the drug-induced haploinsufficient condition. For these 13 TAM-sensitive genes, we conducted a comparative analysis of their Gene Ontology (GO) ‘biological process’ terms identified from other genome-wide screenings of the budding yeast deletion library and the MCF7breast cancer cell line. Several TAM-sensitive genes overlapped between the yeast strains and MCF7 in GO terms including ‘cell cycle’ (cdc2, rik1, pas1, and leo1), ‘signaling’ (sck2, oga1, and cki3), and ‘vesicle-mediated transport’ (SPCC126.08c, vps54, sec72, and tvp15), suggesting their roles in the ER-independent cytotoxic effects of TAM. We recently reported that the cki3 gene with the ‘signaling’ GO term was related to the ER-independent antifungal action mechanisms of TAM in yeast. In this study, we report that haploinsufficiency of the essential vps54 gene, which encodes the GARP complex subunit, significantly aggravated TAM sensitivity and led to an enlarged vesicle structure in comparison with the SP286 control strain. These results strongly suggest that the vesicle-mediated transport process might be another action mechanism of the ER-independent antifungal or cytotoxic effects of TAM.
Potential biomarkers and signaling pathways associated with the pathogenesis of primary salivary gland carcinoma: a bioinformatics study
Authors: Bayat Zeynab , Ahmadi-Motamayel Fatemeh , Parsa Mohadeseh Salimi , Taherkhani Amir
Published: December 2021

Salivary gland carcinoma (SGC) is rare cancer, constituting 6% of neoplasms in the head and neck area. The most responsible genes and pathways involved in the pathology of this disorder have not been fully understood. We aimed to identify differentially expressed genes (DEGs), the most critical hub genes, transcription factors, signaling pathways, and biological processes (BPs) associated with the pathogenesis of primary SGC. The mRNA dataset GSE153283 in the Gene Expression Omnibus database was re-analyzed for determining DEGs in cancer tissue of patients with primary SGC compared to the adjacent normal tissue (adjusted p-value < 0.001; |Log2 fold change| > 1). A protein interaction map (PIM) was built, and the main modules within the network were identified and focused on the different pathways and BP analyses. The hub genes of PIM were discovered, and their associated gene regulatory network was built to determine the master regulators involved in the pathogenesis of primary SGC. A total of 137 genes were found to be differentially expressed in primary SGC. The most significant pathways and BPs that were deregulated in the primary disease condition were associated with the cell cycle and fibroblast proliferation procedures. TP53, EGF, FN1, NOTCH1, EZH2, COL1A1, SPP1, CDKN2A, WNT5A, PDGFRB, CCNB1, and H2AFX were demonstrated to be the most critical genes linked with the primary SGC. SPIB, FOXM1, and POLR2A significantly regulate all the hub genes. This study illustrated several hub genes and their master regulators that might be appropriate targets for the therapeutic aims of primary SGC.
An in-silico approach to design potential siRNAs against the ORF57 of Kaposi’s sarcoma-associated herpesvirus
Authors: Rahman Anisur , Gupta Shipan Das , Rahman Md. Anisur , Tamanna Saheda
Published: December 2021

Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few human oncogenic viruses, which causes a variety of malignancies, including Kaposi's sarcoma, multicentric Castleman disease, and primary effusion lymphoma, particularly in human immunodeficiency virus patients. The currently available treatment options cannot always prevent the invasion and dissemination of this virus. In recent times, siRNA-based therapeutics are gaining prominence over conventional medications as siRNA can be designed to target almost any gene of interest. The ORF57 is a crucial regulatory protein for lytic gene expression of KSHV. Disruption of this gene translation will inevitably inhibit the replication of the virus in the host cell. Therefore, the ORF57 of KSHV could be a potential target for designing siRNA-based therapeutics. Considering both sequence preferences and target site accessibility, several online tools (i-SCORE Designer, Sfold web server) had been utilized to predict the siRNA guide strand against the ORF57. Subsequently, off-target filtration (BLAST), conservancy test (fuzznuc), and thermodynamics analysis (RNAcofold, RNAalifold, and RNA Structure web server) were also performed to select the most suitable siRNA sequences. Finally, two siRNAs were identified that passed all of the filtration phases and fulfilled the thermodynamic criteria. We hope that the siRNAs predicted in this study would be helpful for the development of new effective therapeutics against KSHV.
Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma
Authors: Rath Sonali , Jagadeb Manaswini , Bhuyan Ruchi
Published: December 2021

Moringa oleifera is nowadays raising as the most preferred medicinal plant, as every part of the moringa plant has potential bioactive compounds which can be used as herbal medicines. Some bioactive compounds of M. oleifera possess potential anti-cancer properties which interact with the apoptosis protein p53 in cancer cell lines of oral squamous cell carcinoma. This research work focuses on the interaction among the selected bioactive compounds derived from M. oleifera with targeted apoptosis protein p53 from the apoptosis pathway to check whether the bioactive compound will induce apoptosis after the mutation in p53. To check the toxicity and drug-likeness of the selected bioactive compound derived from M. oleifera based on Lipinski’s Rule of Five. Detailed analysis of the 3D structure of apoptosis protein p53. To analyze protein’s active site by CASTp 3.0 server. Molecular docking and binding affinity were analyzed between protein p53 with selected bioactive compounds in order to find the most potential inhibitor against the target. This study shows the docking between the potential bioactive compounds with targeted apoptosis protein p53. Quercetin was the most potential bioactive compound whereas kaempferol shows poor affinity towards the targeted p53 protein in the apoptosis pathway. Thus, the objective of this research can provide an insight prediction towards M. oleifera derived bioactive compounds and target apoptosis protein p53 in the structural analysis for compound isolation and in-vivo experiments on the cancer cell line.
Measurement of Barriers, Attitudes, and Expectations for Sitting Less in Pregnancy
Authors: Gibbs Bethany Barone , Jones Melissa A. , Whitaker Kara M. , Ross Sharon Taverno , Davis Kelliann K.
Published: December 2021

Objective: Our objective was to develop, validate, and describe findings from an instrument to measure barriers, attitudes, and outcome expectations of sitting less in pregnant women. Methods: This validation (sub-study 1) and descriptive study (sub-study 2) evaluated a new questionnaire
measuring sedentary time in pregnant women (N=131) in each trimester. Results: In sub-study 1, construct validity was supported by associations between device-measured sedentary time and questionnaire scores. An optimized questionnaire removed infrequently reported and non-correlated items.
The original and optimized questionnaires with scoring instructions are provided. In sub-study 2, physical symptoms and work were most commonly reported as major reasons for sitting in pregnancy, followed by leisure, family, and social activities. Some women reported limiting sitting due to
boredom/restlessness, to improve energy or health, and to control weight. In the third trimester, some women reported sitting more/less due to pain and encouragement from family, friends, and co-workers. Few women reported household chores or pregnancy risks as reasons to sit, felt sitting
was healthy or necessary during pregnancy, or were encouraged to sit by healthcare providers. Conclusions: The developed questionnaire demonstrated validity and identified barriers to and expectations of sitting less during pregnancy. Prenatal interventions to reduce sitting should address
general and pregnancy-specific barriers.
Smoking Behavior Changes during COVID-19 among Korean Adults
Authors: Han Mi Ah , Kim Hae Ran
Published: December 2021

Objectives: In this study, we investigated the changes in smoking behavior during the COVID-19 outbreak in Korea in 2020. We also examined the influence of general characteristics and mental health problems due to COVID-19 on changes in smoking behavior. Methods: We collected data from August to October 2020 from adults aged 19 years and older from the Korea Community Health Survey (N=229,269). Results: Among current smokers (N=39,534), 11.0% reported an increase in smoking, and 12.8% reported a decrease in smoking. Overall, 33.3% reported perceived stress and 3.7% reported depression. Participants reported COVID-related anxiety about infecting family (83.0%), economic damage (76.3%), blame or harm from others (66.5%), infection (60.6%), and death (31.3%). Lower education level, living alone, and poor subjective health status were associated with increased smoking. Being a woman and being of older age were associated with decreased smoking. Stress, depression, and anxiety about economic damage due to COVID-19 were more likely to result in increased smoking. Anxiety related to death due to COVID-19 was more likely to result in decreased smoking. Conclusion: These findings provide insight into the changes in smoking behavior caused by COVID-19.
Strategic Analysis of Collaborative Governance for Disaster Management on Forest and Land Fires in Indonesia
Authors: Ruswandi Dody , Sumartono Sumartono , Maarif Syamsul , Wijaya Andy Fefta
Published: December 2021

This research aims to understand the strategic analysis of collaborative governance on forest and land fire disasters at the ontological and sociological level that are very significant in reducing risk of natural disasters in Indonesia. The problem is very interesting to be analyzed by conducting a descriptive qualitative research based on theory of public policy, collaborative governance, and strategic management. The data were collected through in-depth interview, observation, and related documentation in forest and land fire cases in Indonesia. The data were analyzed by using interactive models, which are data reduction, data display, data verification, and supported by triangulation. The results were based on ontological and sociological level by using collaborative governance perspective and strategic analysis of internal, external, supporting, and inhibiting factors for reducing disaster risks and improving disaster management. Vision and mission of public policies on disaster management are needed for improving and providing information to stakeholders regarding regulations and sanctions in natural disaster management and produce a revised relevant regulation for state agencies as public officials in making regulations on disaster management in Indonesia.
ANALYSIS OF THE TEMPERATURE FIELD IN A MOLD CAVITY FOR POLYMER INJECTION PROCESS
Authors: BENITEZ LOZANO ADRIAN JOSE , VARGAS ISAZA CARLOS ANDRES , MONTEALEGRE RUBIO WILFREDO
Published: December 2021

A common situation in the design of injection molds is to achieve an efficient performance in terms of heat transfer, this will allow a higher production rate with better finished parts [1]. One of the most important factors in the design is the cooling time: about 80% of the processing time is determined by it [2]. Seeking to contribute with the increase of productivity, this work presents results of simulations through the finite volume method (MVF) of the injection molding process; those results are compared with an analysis of design of experiments (DOE) with different injection conditions, revealing the study variables that are fundamental to improve the process. Thus, a statistical analysis and a computer simulation analysis are presented to identify the variables inherent to the process and recommend their values.
ROBUST AND SECURE S-BOX DESIGN WITH GATED HYBRID ENERGY RECOVERY LOGIC (GHERL) FOR IOT APPLICATIONS
Authors: GLADWIN RUBAN , KASTHURI NEHRU
Published: December 2021

The smart Internet of Things (IoT) network relies heavily on data transmission over wireless channels. Hence, it should be designed to be robust against the attacks from hackers and antagonists. The confidentiality in IoT devices is directly proportional to the complexity and power consumption. To mitigate these issues, this paper proposes a secure Substitution Box (S-Box) design that is exploited in the IoT for cyber security applications. The S-Box is based on Gated Hybrid Energy Recovery Logic (GHERL) that is an amalgamation of two different techniques as adiabatic logic and power gating. Adiabatic logic is preferred to attain high energy efficiency in practical applications such as portable and handheld devices. Power gating technique is preferred to reduce the leakage power and energy consumption. The proposed GHERL XOR gate and S-Box are implemented with 125nm technology in Tanner EDA tool. The consequences of the experiments exhibits that the novel S-Box design with GHERL XOR decreases the power consumption by 1.76%, 35.26%, 36.81%, 41.01% and reduces the leakage power by 58.54%, 20.27%, 27.38%, 13.63% when compared with the existing techniques such as S-Box with sleep transistor, dual sleep transistor, dual-stack and sleepy keeper approach.

Keywords: Adiabatic logic, Power Gating, Internet of Things, S-Box
MODELING THE BARRIERS OF SOCIAL DIMENSION IN SUSTAINABLE SUPPLIER CHAIN MANAGEMENT
Authors: Chen Chen Jih-Kuang
Published: December 2021

In the supply chain, a core business and its upstream and downstream companies systematically coordinate the Triple Bottom Line (TBL) to maximize economic benefits, social responsibility, and environmental protection from a strategic height.
Electron spin resonance study of spin fluctuation in multiferroic MnSb2O6
Authors: Wang Zhe , Xu Jie-Min , Wang Wen-Jun , Li He-Xuan , Zou You-Ming , Yu Lu , Qu Zhe ,   Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Sciences, Chinese Academy of Sciences, Hefei 230031, China,   Science Island Branch of Graduate School, University of Science and Technology of China, Hefei 230031, China,   CAS Key Lab of Photovoltaic and Energy Conservation Materials, Hefei Institutes of Physical Sciences, Chinese Academy of Sciences, Hefei 230031, China
Published: December 2021

The magnetic materials with a chiral crystallographic lattice have hold neither inversion center nor mirror plane, leading to the emergence of Dzyaloshinskii-Moriya interaction and exotic physical phenomena like skyrmion, multiferroicity, and chiral solition lattice. The trigonal oxide MnSb2O6 is recognized as a novel chiral-lattice helimagnet with unusual multiferroic properties, where magnetic field enables the selecting of a single ferroelectric domain and a slight tilting of field direction can trigger the reversal of electric polarization. Single crystal of MnSb2O6 is prepared by the flux method. The magnetic susceptibility at 2 K shows a linear field dependent behavior except in the low field region. The magnetization shows a deviation from linearity at around 0.2 T for H⊥c, while a step-like anomaly is observed at about 1 T for H//c, suggesting the domain selection and spin-flop transition, respectively. The electron spin resonance parameters, such as the resonance field, the g-factor and the linewidth ΔH, are obtained by performing single Lorentzian line. Interestingly, the resonance field shows a distinct, anisotropic temperature dependent behavior when further cooling, the resonance field shifts towards the lower field direction for H⊥c, while it shifts towards higher field direction for H//c. Excluding several mechanisms for this FM-like temperature dependent behavior of the resonance field, combining the ground state of spiral phase and its unique multiferroic properties, we suggest that the spiral magnetic structure of the ground state of MnSb2O6 forms a conical magnetic structure under external magnetic field. Based on this, we can speculate the variation of ferroelectric polarization intensity with moderate and higher magnetic field. Moreover, the critical fitting of the ESR linewidth gives an unusual small critical index, p = 0.49 for H⊥c and p = 0.54 for H//c, implying that the magnetism possesses a two-dimensional characteristic and competitive interaction.
Measurement of medium-energy proton flux
Authors: Zhang Yan-Wen , Guo Gang , Xiao Shu-Yan , Yin Qian , Yang Xin-Yu ,   National Innovation Center of Radiation Application, Department of Nuclear Physics, China Institute of Atomic Energy, Beijing 102413, China
Published: December 2021

Proton is the main particle component in the space radiation environment. The proton single event effect cannot be ignored with the continuous development of semiconductor technology. Accelerator simulation is the most important method to evaluate the single event effect caused by proton radiation, and the accurate measurement of proton flux is the most critical aspect in the device evaluation process. The research is based on the 100 MeV proton single-event irradiation device of the Atomic Energy Institute, which breaks through the wide-range mid-energy proton fluence rate measurement technology. The detection tools are developed such as Faraday cup, plastic scintillator detectors and secondary electron emission monitors, which can be used for measuring the proton beam current in a wide range. Faraday cup and plastic scintillator detector can be used for measuring the high flux proton and the low flux proton, respectively. Secondary electron emission monitor can be used for conducting the online real-time measurement. The proton fluxes in a range of 106– 107 p·cm–2·s–1 are measured by using two separate detectors.

The analysis of the fluence rate uncertainty is carried out. The uncertainty of measurement results mainly include three aspects: measurement method, measuring instrument and equipment, and repeatability of multiple measurement results. Here in this work, the Faraday cup is taken for example to analyze the uncertainty sources in the proton flux measurement. The measurement methods include the calculation of the collection efficiency of the Faraday cup (collection efficiency + escape rate = 1) and the calculation method of flux (flux = current/collection area). For the measuring instruments and equipment, mainly including 6517A and other electronic devices, their errors are determined by the accuracies of the instruments themselves. Repeatability of multiple measurement results mainly from the error caused by the instability of the accelerator beam output, the error caused by randomness of multiple measurement results, and the error given by the statistical method. The analysis shows that the uncertainty of flux measurement by Faraday cup is 7.26%, and the uncertainty of flux measurement by plastic scintillator detector is 1.64%.

The flux measurement of the proton fluence rate has reached the level of similar devices in the world, filling the gap in this field in China. It has a certain reference and guiding significance for the follow-up study of medium- and high-energy proton beam measurement in China. The mid-energy proton flux measurement system and uncertainty analysis method established in this study lay the foundation for accurately evaluating the component radiation effects.
The sonographer dilemma: Ultrasound follow-up in patients with small gallbladder polyps
Authors: Pedersen Malene Roland Vils
Published: December 2021

What should sonographers recommend to patients diagnosed with small gallbladder polyps? Is follow-up always the solution? And for how many years should we encourage patients to participate in a follow-up ultrasound program? This tutorial discusses current research and guidelines.
Projection radiography of the ankle; the views used for different indications vary between medical imaging departments
Authors: Guðjónsdóttir Jónína , Haraldsdóttir Silja
Published: December 2021

Plain radiographs are used for initial evaluation of many conditions of the ankle. Many different radiographic views are described in positioning textbooks but evidence on which views to use, in which case, is scarce. The aim of this study was to map imaging procedures related to four indications for ankle projection radiography. A questionnaire was sent to all medical imaging departments in Iceland with questions about acquisition technique for ankle radiography views and which views were used for selected indications. Answer was received from 14 of the 28 departments.  All departments gave very similar descriptions of the four most common views. In the case of trauma, all but one department used four views but for control of trauma or operation, four different combinations of views were found using from two to four images. For detrition and osteomyelitis, four views were more common in the larger departments but there was not a statistically significant difference. Eight different combinations of the number of views for the four indications were found. The study indicates that there is a need for standardization in image acquisition protocols. More studies are needed to support decisions about how many views are necessary for the most common ankle radiography indications.
Lubricating culture awareness and critical thinking through humour
Authors: Takovski Aleksandar
Published: December 2021

There is an ample evidence supporting the benefits of instructional humour, among which increased attention and interest, information retention and learning speed, more productive learning environment, a more positive image of the instructor, more efficient acquisition of linguistic and cultural competencies, an increased conversational involvement, enhanced cultural awareness and more stimulated critical thinking. However, most of the research findings rely on what is termed appropriate humor such as puns, jokes, anecdotes and alike, while potentially offensive humour that relates to sexual, ethnic, religious, political identity is generally labeled inappropriate and advised to be avoided in the classroom environment. It is in this particular context that this study seeks to test the potential of such humour, sexual and ethnic in particular, to act as a tool of increasing cultural awareness and stimulate critical thinking among university students. To do so, the study relies on an experimental class design combining few in-class and extracurricular activities created by using sexual and ethnic humour samples.
Ephemeral mimetics: memes, an X-ray of Covid-19
Authors: Martínez Cardama Sara , García-López Fátima
Published: December 2021

The Covid-19 pandemic has prompted a crisis with consequences for public health, but also with economic, social and cultural implications that have affected all layers of society to a greater or lesser extent. Communication has been impacted by the immediacy and virality of messages and misinformation has galloped across social platforms. Against that backdrop, memes have emerged as a powerful means to channel citizen sentiment. A study of these digital objects is essential to understanding social network-based communication during the pandemic. The qualitative research reported here analyses the role of memes in communication on Covid-19, studies their development and defends their status as one of this generation’s cultural artefacts that, as such, merits preservation. Meme evolution is studied using Kübler-Ross’s stages of grief, which has been applied in a number of contexts involving psychological change. Studying memes in those terms both brings information on the evolution of citizens’ concerns to light and proves useful to sound out social media communication around the pandemic media. The challenges to be faced in meme preservation are defined, along with the ways in which heritage institutions should ensure the conservation of these cultural objects, which mirror early twenty-first century communication and world views and in this case provide specific insight into one of the most significant historic circumstances of recent decades.
Germen de tarificación de las sanciones ambientales
Authors: Tapia Alvial Claudio
Published: December 2021

En este trabajo se analiza la decisión de la Corte Suprema en el caso FMC Ltda. con la Superintendencia del Medio Ambiente. Vinculamos la decisión con las líneas jurisprudenciales atingentes y argumentamos que implica algunos efectos perjudiciales e.g., la tarificación de las sanciones ambientales.
Development of a Numerical Model to Analyze the Formation and Development Process of River Mouth Bars
Authors: Kim Yeon-Joong , Woo Joung-Woon , Yoon Jong-Sung , Kim Myoung-Kyu
Published: December 2021

An integrated sediment management approach that includes the recovery of the amount of declined sediment supply is effective as a fundamental solution to coastal erosion. During planning, it is essential to analyze the transfer mechanism of the sediments generated from estuaries (the junction between a river and sea) to assess the amount and rate of sediment discharge (from the river to sea) supplied back to the coast. Although numerical models that interpret the tidal sand bar flushing process during flooding have been studied, thus far, there has been no study focusing on the formation and development processes of tidal sand bars. Therefore, this study aims to construct wave deformation, flow regime calculation, and topographic change analysis models to assess the amount of recovered sediment discharge and reproduce the tidal sand bar formation process through numerical analysis for integrated littoral drift management. The tidal sand bar formation process was simulated, and the wave energy and duration of action concepts were implemented to predict the long-term littoral movement. The river flux and wave conditions during winter when tidal sand bars dominantly develop were considered as the external force conditions required for calculation. The initial condition of the topographic data directly after the Maeupcheon tidal sand bar flushing during flooding was set as the initial topography. Consequently, the tidal sand bar formation and development due to nearshore currents dependent on the incident wave direction were reproduced. Approximately 66 h after the initial topography, a sand bar formation was observed at the Maengbang estuary.
Interaction Effect between Caissons by Installation of New Caisson on Existing Caisson Breakwater in Second Order Stokes Wave Condition
Authors: Park Min Su
Published: December 2021

In order to increase the structural stability of existing caisson breakwater, the design and the construction is carried out by installation of new caissons on the back or the front of old caissons. In this study, we use the ANSYS AQWA program to analyze the wave forces acting on individual caisson according to effects of wave structure interaction when new caissons are additionally installed on existing caisson breakwater. Firstly, the wave force characteristics acting on the individual caisson were analyzed for each period (frequency) in the frequency domain. In time domain analysis, the dynamic wave force characteristics were strongly influenced by the distance between caissons on the frequency at which the unusual distribution of wave forces occurs.
Method of the Laboratory Wave Generation for Two Dimensional Hydraulic Model Experiment in the Coastal Engineering Fields: Case of Random Waves
Authors: Lee Jong-In , Bae Il Rho , Kim Young-Taek
Published: December 2021

The experiments in coastal engineering are very complex and a lot of components should be concerned. The experience has an important role in the successful execution. Hydraulic model experiments have been improved with the development of the wave generator and the advanced measuring apparatus. The hydraulic experiments have the advantage, that is, the stability of coastal structures and the hydraulic characteristics could be observed more intuitively rather than the numerical modelings. However, different experimental results can be drawn depending on the model scale, facilities, apparatus, and experimenters. In this study, two-dimensional hydraulic experiments were performed to suggest the guide of the test wave(random wave) generation, which is the most basic and important factor for the model test. The techniques for generating the random waves with frequency energy spectrum and the range for the incident wave height [(HS)M/(HS)T = 1~1.05] were suggested. The proposed guide for the test wave generation will contribute to enhancing the reliability of the experimental results in coastal engineering.
Ecos Armoriais: entrevista com Clóvis Pereira
Authors: Santos Marília Paula dos
Published: December 2021

Clóvis Pereira é um compositor brasileiro. Destaca-se por enfatizar em suas composições características que estão presentes nas culturas populares do Nordeste. Esse olhar voltado para sua própria cultura está relacionado com a vida do próprio compositor e com as aulas que ele teve, nos anos cinquenta do século XX, com César Guerra-Peixe. No final dos anos sessenta Clóvis Pereira foi convidado, por Ariano Suassuna, para fazer parte de um grupo que estava buscando criar uma arte autenticamente brasileira. Junto com Jarbas Maciel e Cussy de Almeida, Clóvis Pereira foi um dos artistas responsáveis por criar a música armorial. Dos três primeiros músicos “armoriais” apenas Clóvis Pereira permanece vivo. Em 2017 eu o entrevistei para uma pesquisa sobre as influências armoriais na música. Nesse texto apresentamos os principais trechos dessa entrevista, com o objetivo de registrá-la e disponibilizá-la.
Análise do uso de informações contábeis e características dos síndicos na administração de condomínios: um estudo de caso
Authors: Rezende Bruno Badue Cunha , Silva Taís Duarte , Leal Edvalda Araujo
Published: December 2021

O presente estudo considera o papel da contabilidade na gestão condominial, bem como evidências anteriores que apontaram problemas que prejudicam esse processo de gestão, como a falta de qualificação técnica dos síndicos. Diante disso, o presente estudo teve como objetivo principal identificar a percepção dos síndicos quanto ao uso de informação contábil gerencial e financeira na gestão dos condomínios, e como objetivo secundário, comparar as características desses síndicos com a percepção deles quanto ao uso dessas informações contábeis e com as demandas que eles apresentam à empresa administradora de condomínios. Para atingir o objetivo proposto, utilizou-se um questionário, o qual foi embasado nos estudos anteriores e permitiu identificar aspectos referentes ao uso da contabilidade na gestão condominial, já para a análise das características dos síndicos, utilizou-se como base a Teoria dos Altos Escalões. A análise foi realizada com 23 síndicos clientes da empresa Alpha de condomínios e uma entrevista com a diretora da empresa, localizada em Uberlândia-MG. Na percepção dos síndicos os maiores benefícios com uso informações contábeis gerenciais e financeiras são a prestação de contas, o controle de fluxo de caixa e a tomada de decisões. Sobre processo de gestão dos condomínios destacou-se o uso de informações do Controle de Fluxo de Caixa Operacional, Relatórios de Inadimplentes e Balancete de Movimentação Anual e sugere-se que algumas características dos síndicos interferem nesse processo de gestão. A partir desses resultados evidenciou-se a importância do aprimoramento da prestação de serviço contábil à comunidade condominial e da preparação dos síndicos para que aperfeiçoem as práticas usadas na gestão condominial.
Resenha do livro: Teoria da contabilidade financeira: fundamentos e aplicações / organização Eduardo Flores, Guillermo Braunbeck, Nelson Carvalho. São Paulo: Atlas, 2018.
Authors: Kruger Silvana Dalmutt
Published: December 2021

Esta resenha tem o objetivo de apresentar uma síntese das principais ideias discutidas no livro Teoria da contabilidade financeira: fundamentos e aplicações, organizado por Eduardo Flores, Guillermo Braunbeck e Nelson Carvalho, lançado no ano de 2018, pela Editora Atlas.
Processos de Inclusão e Educação do Campo: Desafios da Educação Básica no Contexto das Novas Tecnologias
Authors: Mörschbächer Melina , Reis Deyse
Published: December 2021

A educação tem se orientado pelo conceito, ainda que impreciso, de democracia. O reconhecimento da diversidade resultante de elementos econômicos, políticos, sociais e culturais tem motivado a sociedade a exigir projetos políticos-pedagógicos que atendam a diferentes expectativas e necessidades. Nesse sentido, é fundamental compreender a educação inclusiva, suas modalidades, suas características e seus principais desafios. O problema que orienta o presente artigo diz respeito às perspectivas de inclusão na educação do campo. Para tanto, é abordado o ideal de inclusão na educação básica, a educação do campo como direito e, por fim, os desafios e impasses da educação do campo na atualidade, especialmente no contexto das novas Tecnologias da Informação e Comunicação (TICs). A pesquisa se ampara em estudos, legislações e experiências de educação do campo e apresenta uma análise de conteúdo de publicações científicas recentes sobre os desafios escolares da educação do campo, de modo a identificar discursos e ações que podem ser mobilizados na elaboração de novos projetos de ensino e aprendizagem.
INTERFACES INTERCULTURELLES ET MULTILINGUES D'ACCÈS l’INFORMATION ET AUX CONNAISSANCES
Authors: El Hadi Widad Mustafa
Published: December 2021

Article est une prise de position (position paper) sur l’importance de respecter la diversité culturelle et linguistique dans la conception des SOC. Ce respect constitue l’un des principes d’éthiques dans l’organisation des connaissances et considéré comme un des fondements des Droits de L’homme (Déclaration universelle des droits de l’homme). Il reposera sur une brève revue de la littérature sur l’éthique dans l’organisation des connaissances (OC), le relativisme linguistique ainsi que sur les approches culturelles de l’organisation des connaissances (Guimarães, 2000 ; 2015) ; Favier et Mustafa El Hadi (2013) ; Mustafa El Hadi 2015) . entre autres, et de l’accès à l’information dans un monde de plus en plus globalisé.
ORGANIZAÇÃO, GESTÃO E REPRESENTAÇÃO DA INFORMAÇÃO E DO CONHECIMENTO NA ARQUIVÍSTICA
Authors: Corujo Luís Miguel Nunes , Freitas Maria Cristina Vieira de
Published: December 2021

Diferentes estudos abordam a questão da organização, gestão e representação da informação e do conhecimento, no âmbito da Ciência da Informação. Algumas destas abordagens alargam o espetro para as interações possíveis com a Arquivística. Pretende-se identificar alguns desses estudos e analisar as perceções de autores sobre essas matérias, tendo como alvo alguma da produção científica recente neste âmbito. Trata-se de uma abordagem qualitativa, baseada no método de Investigação Documental. As análises incidem sobre 21 textos, publicados entre 2016 e 2021. Os resultados apontam para a subdivisão do tema principal em três eixos discursivos secundários, reveladores de diferentes, mas complementares, perceções (ou discursos): i) Organização e representação da informação e do conhecimento arquivístico: especificidades e relações; ii) Representação e descrição da informação e do conhecimento arquivístico: interlocuções e desafios; iii) Representação da informação e do conhecimento arquivístico: processos e produtos. As conclusões encaminham a Arquivística e a Ciência da Informação para um território comum - a Representação da Informação e do Conhecimento - , para que a primeira (a Arquivística) possa beneficiar-se, especialmente, no que respeita à eficácia na recuperação da informação, dos conhecimentos científicos consolidados pela segunda ( a Ciência da Informação).
VDAC1 oligomerization may enhance DDP‐induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage
Authors: Zhu Xueqin , Luo Lei , Xiong Yanyan , Jiang Nan , Wang Yurun , Lv Yuan , Xie Ying
Published: December 2021

Cisplatin (DDP)‐based chemotherapy is a preferred treatment for a broad spectrum of cancers, but the precise mechanisms of its hepatotoxicity are not yet clear. Recently, the role of voltage‐dependent anion channel protein 1 (VDAC1) in mitochondrial activity and cell apoptosis has attracted much attention. Our aim was to investigate the effects of mitochondrial outer membrane protein VDAC1 oligomerization in DDP‐induced hepatocyte apoptosis. L‐02 hepatocytes were divided into 4 groups: (a) control group, (b) 4,4'diisothiocyanate‐2,2'‐disulfonic acid (DIDS; 40 μm) group, (c) DDP (5 μm) group, and (d) DDP and DIDS combination group. Cell apoptosis was tested by Annexin V/FITC assay, protein expression of caspase‐3, γH2AX and NDUFB6 were observed by western blot assay, reactive oxygen species (ROS), and mitochondrial superoxide anion radical (O2•−) were detected by DCFH‐DA and MitoSOX probe, and DNA damage was assessed by comet assay. Moreover, the activity of mitochondrial respiratory chain complex I was determined by the colorimetry method. Compared with the control group, apoptosis rate and activated cleaved‐caspase‐3 protein, ROS and O2•− generation, DNA damage marker comet tail length, and γH2AX protein level increased in the DDP treatment group (P < 0.05). Activity of mitochondrial COXI decreased after DDP treatment (P < 0.05). DIDS, as a VDAC1 oligomerization inhibitor, antagonized DDP‐induced apoptosis by diminishing oxidative stress and DNA damage and protecting mitochondrial complex protein. These results show that VDAC1 oligomerization may play an important role in DDP‐induced hepatocyte apoptosis by increasing ROS and mtDNA leakage from VDAC1 pores, exacerbating oxidative stress and mtDNA damage.
Acquired Von Willebrand Disease
Authors: Viola Filomena Gemma Rinalda , Bellincampi Lorenza , Bernardini Sergio
Published: December 2021

Acquired von Willebrand disease (AVWD) is a heterogeneous, life‐threatening and bleeding disorder, usually associated with underlying disorders ranging from lympho‐ and myeloproliferative disorders to certain type of solid tumours, autoimmune diseases, cardiovascular disorders and drug therapies. AVWD is a complex multicausal disorder that is very often underdiagnosed or misdiagnosed. AVWD is usually characterised by a negative personal or family bleeding history and a late onset, even if it has to be considered in childhood. It is characterised by several different pathogenetic mechanisms, but all of them cause low circulating levels of von Willebrand factor (VWF), even if normally synthesised and released. VWF plays an important role in haemostasis, participating actively in platelet–subendothelium and platelet‐to‐platelet adhesion, promoting platelet aggregation and is a carrier protein for coagulation factor VIII. No simple, single laboratory test is available to screen for AVWD, and this makes it very challenging for clinicians to diagnose and treat the disorder. AVWD diagnosis requires a very experienced laboratory and is made using several specific laboratory tests.

Key Concepts

Primary haemostasis: pivotal role of von Willebrand factor (VWF) in platelet aggregation and adhesion.

VWF protein's quaternary structure and its functional role.

Congenital or acquired VWF deficiency.

Acquired von Willebrand disease (AVWD) is a bleeding disorder characterised by mucocutaneous bleeding; although AVWD has, generally, a mild clinical impact, it must be seriously considered in some medical conditions.

Role of autoantibodies and metalloproteases in AVWD.

Clinical chemistry laboratory tests have an important function in the diagnosis of AVWD.

Desmopressin achieves the main treatment goals of AVWD, such as control acute bleeding and prevent bleeding in high‐risk situations.
Circulation in Vertebrates
Authors: Farrell Anthony P , Eliason Erika J
Published: December 2021

The vertebrate circulatory system consists of a central pump (the heart), a system of tubes (the vascular and lymphatic vessels), fluid (blood and lymph) and a control system (neural, endocrine, paracrine and autocrine factors) that serves to transport gases, nutrients and other substances around the body.

Key Concepts

Gases, nutrients, immune factors, and products of metabolism are transported in the blood around the body through a closed network of branching blood vessels.

The heart is a muscular pump with a specialised pacemaker region that normally initiates the heartbeat, though heartrate is modified by sympathetic and parasympathetic control.

Excitation‐contraction (E‐C) coupling refers to the linking of the action potential of a cardiac cell and the contraction of a muscle fibre; Ca
2+
cycling is a critical component of E‐C coupling.

Cardiac morphology and circulation patterns vary across vertebrate groups; mammals, birds and crocodiles have a double circulation while water‐breathing fishes have a single circulation.

Arterioles control blood flow to local capillary beds in the peripheral circulation via changes in arteriole diameter
Fischerella
Authors: Miller Scott R.
Published: December 2021

Fisch.er.el'la. N.L. fem. n.
Fischerella
, probably named for B. Fischer, botanical bacteriologist, 1852–1915.

Cyanobacteria / Subsection V / Incertae Sedis / Fischerella

Multicellular, with uniseriate true branches (secondary trichomes) that arise from a primary trichome (main axis) and which are composed of cells that are generally longer than broad (particularly those distal from the base). Mature trichomes do not fragment. The primary trichome is also mainly uniseriate but may become multiseriate in part as a consequence of cell divisions in more than one plane. Cells in multiseriate regions become enlarged and are often semispherical in shape, and the axis is seldom more than 2–3 cells in thickness. The older cells of a primary trichome may become separated from each other by extracellular material and may act as akinetes. Most of the widened cells of the primary trichome, however, display a true filamentous nature, with only a peptidoglycan septum separating cells. Active dispersal is by means of a motile hormogonium. The main axis of a new primary trichome forms when hormogonium motility ceases, cells enlarge, and cell divisions that are parallel or diagonal (oblique) to the long axis commence; some of the resulting cells elongate to form secondary trichomes. Fix nitrogen with lateral, terminal, or intercalary heterocysts (= heterocytes) that may differentiate on both primary and secondary trichomes.

DNA G + C content (mol%)
: 38.6–42.6 (genome sequence data).

Type species
:
Fischerella thermalis
Schwabe ex Gomont 1895.
2021: Making COVID‐caused changes permanent, for better or worse
Authors: Knopf Alison
Published: December 2021

What started in 2020 — COVID‐19 — continued with a vengeance in 2021, but last year, some of the changes put into place due to the virus became permanent, at least for now. These included relaxations of the rules regarding buprenorphine and methadone, far greater use of telemedicine and other less sanguine changes, such as to‐go alcohol. In the meantime, opioid overdoses continued to go up, this time with the addition of methamphetamine and cocaine.