bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovation environment as a key factor in the development of the region's innovative potential
Authors: Akzhanova G.A.
Published: January 2024

Object: The regional innovation environment, as the major factor, is the object of research for the development of innovative potential.Methods: This article uses such research methods as generalization, comparison, systematization and statistical analysis.Results: It is important to reveal regional features, the group of factors that contribute to the development of innovative potential in an innovative environment. The innovation environment is considered from the point of view of the institutional, corporate and educational innovation environment that promotes effective innovation in the region. The basic factors at the micro-, meso-, macro levels that have a positive effect on the development of the region's innovation environment are revealed. The main indicators of innovation activity and dynamics of internal expenditures on research in Kazakhstan for 2015–2019 are analyzed in order to determine the significance of the educational innovation environment.Conclusions: The conclusion is made about the importance of educational, institutional and corporate innovation environments based on the identified activities. The rational use and development of innovative potential is possible only when the studied factors of the innovation environment interact, which will allow us to concentrate all the obvious and hidden opportunities of the region into a single innovation system.
Pathological evaluation of the effects of the drug clozalbent f on tissues and cytostructure of the trematode Fasciola gigantica (Cobbold, 1855)
Authors: Bittirov A. M. , Gazaeva A. A. , Bittirov I. A. , Bittirov R. B.
Published: January 2024

The aim of the study was a pathomorphological evaluation of the effect of the new drug Clozalbent F (Clozalbent F) on populations of the trematode Fasciola gigantica (Cobbold, 1855) with monoinvasion of fasciolеsis in cows.

   In the experiment, on days 7-10 after a single oral application to cows spontaneously infected with trematodes Fasciola gigantica, the effects of the drug Clozalbent F (Clozalbent F) at a dose of 1.25 g/10 kg of live weight appear in the form of irreversible pathomorphological changes in organs and tissues marit and premarital. In the body of trematodes, carbohydrate, protein, water and salt metabolism is disturbed, toxins are formed, and hydropic dystrophy of tissues increases with large amounts of water in them. Hydration of F. gigantica cells and tissues causes them to swell, then decay and necrosis. Under the influence of Closalbent F, vacuoles are formed in the tegument of trematodes in the intercellular spaces filled with turbid moisture. The drug enters the body of F. gigantica through the neo-dermis, causing irreversible path changes (destruction, disorganisation, decomposition, autolysis, protein, carbohydrate, hydropic dystrophy, necrobiosis and necrosis) of cells and tissues in mature trematodes. On the 7-10th day of the experiment, after the action of the Clozalbent F at a dose of 1,25 g/10 kg of live weight, F. gigantica marita showed complete disintegration of tegument, suckers and genitalia cells, which was confirmed by histological methods (TS, BFS, SA, CHIC) and testifying to its high efficiency and biosafety fasciolеsis in cow.
Implementation of the Istanbul Convention into the National Criminal Legislation in Poland
Authors: Hypś Sławomir
Published: January 2024

The Council of Europe Convention on preventing and combatting violence against women and domestic violence (further: Istanbul Convention) became part of the Polish legal system on August 1, 2015. The ratification process of the Istanbul Convention was marked with difficulties from its very opening for signature. The provisions of the Convention have caused – and continue to arouse – a range of extreme emotions and doubts. The fierce dispute that has emerged over the implementation of the Convention in Poland at some point even led to action being taken for termination. As things have been to date, Poland has not terminated of the Istanbul Convention. Five years following ratification of the Convention, in March 2020, Poland submitted a report on the implementation of measures giving effect to its provisions into the Polish legal system, as required under the monitoring mechanism. Poland’s report was considered by GREVIO, with an assessment made of Polish legislation in this regard and an evaluation report issued in June 2021. Notwithstanding the comments that Poland made to the GREVIO report, the key conclusions of the assessment should be highlighted as regards compliance of Polish criminal legislation with the standard of protection of women against violence, including domestic violence, under the Convention. Since the Convention was opened for signature, and in particular since its ratification, the Polish legislator has introduced a range of amendments to the Criminal Code aimed at raising the standard of protection for victims of domestic violence and of effective prosecution of offenders. This text highlights the most important of these changes and presents the current state of implementation of the Istanbul Convention into Polish criminal law.
Productivity and profitability of upland rice (Oryza sativa L.) under varied crop geometry and soil moisture conservation practices
Authors: Alekhya Gunturi , V. Jayakrishnakumar  , Joseph Biju
Published: January 2024

Rice, a vital staple food, plays a critical role in ensuring food and nutrition security for millions of people. Rice production faces various challenges from both biotic and abiotic stresses, with soil moisture stress being a significant limitation, especially in rainfed upland ecologies. While crop improvement strategies have made progress in addressing abiotic stressors, the complex and diverse nature of these challenges requires a combination of crop improvement and agronomic interventions to stabilize rice productivity and profitability. To explore these factors, an experiment was conducted during the Kharif (rainy) season of 2019 at the instructional farm of the College of Agriculture in Kerala. The aim was to investigate how cropping patterns and in-situ soil moisture conservation practices impact the growth and yield of upland rice. The research employed a Randomized Complete Block Design (RCBD), incorporating two distinct crop configurations and strategies for conserving soil moisture. The findings showed that paired-row planting in conjunction with live cowpea mulching, hydrogel application, and coir pith compost was superior in terms of crop growth, as evidenced by elevated Leaf Area Index (LAI) at 4.81 and increased dry matter production at 5.5 t/ha. Furthermore, this approach resulted in higher grain yield (3.8 t/ha), straw yield (7.7 t/ha), improved moisture content (29.12% at 60 days after sowing and 18.49% at physiological maturity), and reduced proline content (0.26 µmol/g FW). The maximized net returns of 62887 Rs/ha. and a Benefit-to-Cost (B:C) ratio of 1.8 was recorded for upland rice.
Perlindungan Hukum Terhadap Perempuan dari Kekerasan Seksual
Authors: Nova Efren , Edita Elda
Published: January 2024

Perlindungan hukum terhadap perempuan dari tindak pidana kekerasan dan bebas dari penyiksaan atau perlakuan yang merendahkan martabat manusia merupakan hak semua warga negara yang merupakan hak kontitusional yang dijamin dalam Undang-Undang Dasar 1945. Kekerasan seksual adalah isu penting dan rumit dari seluruh peta kekerasan terhadap perempuan karena adanya dimensi yang sangat khas dari perempuan, ketimpangan relasi kuasa antara pelaku dan korban adalah akar kekerasan seksual terhadap perempuan Dalam kurun waktu 5 tahun terakhir ini (2017-2022) berdasarkan data dari Sistim Informasi Online Perlindungan Perempuan dan Anak (SIMFONI PPPA) Kementerian PPPA terungkap bahwa sepanjang tahun 2022 terjadi sejumlah 25.050 kasus kekerasan terhadap perempuan yang menjadi korban kekerasan di Indonesia. Sedangkan di Sumatera Barat pada tahun 2020 sebanyak 94 kasus, tahun 2021 ada sebanyak 104 kasus dan tahun 2022 sebanyak 300 kasus. Dengan diundangkan Undang-Undang Nomor 12 Tahun 2022 tentang Tindak Pidana Kekerasan Seksual ini merupakan upaya pembaharuan hukum serta mengatasi permasalahan dalam perlindungan hukum terhadap perempuan dari Tindak  Kekerasan Seksual  yaitu  sebagai  beriku: mencegah segala bentuk kekerasan seksual, menangani, melindungi, dan memulihkan korban, melaksanakan penegakan hukum dan merehabilitasi pelaku, mewujudkan lingkungan tanpa kekerasaan seksual, dan menjamin ketidak berulangan kekerasan seksual. Hasil Penelitian menunjukan kebijakan yang telah dilakukan Pemerintah Daerah (DP3AP2KB) Propinsi Sumatera Barat dalam rangka perlindungan hukum terhadap perempuan pasca keluarnya UUTPKS adalah pembentukan Unit Pelaksana Teknis Perlindungan Perempuan dan Anak (UPTD PPA) yang merupakan amanah dari UU TPKS, di Sumatera Barat baru terbentuk di 7 (tujuh) Kabupaten /Kota, 3 ( tiga) masih dalam proses akademis dan 7 (tujuh) masih belum terbentuk sama sekali, mengadakan sosialisasi UUTPKS dan aparat penegak hukum di Sumatera Barat belum mengimplementasikan UUTPKS dalam rangka perlindungan hukum terhadap perempuan dalam kasus kekerasan seksual dengan alasan ragu karena belum adanya aturan pelaksanaan dan tetap memakai aturan yang ada.
Indonesian Ombudsman: Strengthening Role in Improving the Quality of Public Services
Authors: Taqwa Taqwa , Rifai Amzulian , Nashriana Nashriana , RS Iza Rumesten
Published: January 2024

When residents have issues with a government agency, they may resort to the impartial Ombudsman. This research looks at how the Indonesian Ombudsman has affected service quality there. This research aims to clarify the need for an Ombudsman in the fight against bad administration and to propose reforms to the legislation that would give them more authority. This research blends a normative judicial approach with a descriptive analytic technique. This research shows that the Indonesian Ombudsman has the potential to become a powerful advocate for improving the quality of government services and protecting people' rights against infringement by the state. The Ombudsman in Indonesia can do a better job of sustaining good governance and guaranteeing justice in the provision of public services if given the sufficient resources and support from the government and society, as well as the required legal framework.
Ausmaß der kommunalen Investitionsbedarfe und Ursachen der unzureichenden Infrastrukturfinanzierung
Authors: Hesse Mario
Published: January 2024

Seit Jahren wird in Deutschland eine Debatte um marode Infrastrukturen und hohe Investitionsrückstände geführt. Diverse, auch methodisch unterschiedlich konzipierte Erhebungen liefern eine ungefähre Vorstellung, was allein auf kommunaler Ebene erforderlich wäre, um die Infrastruktur zu sichern, zu ertüchtigen und an neue Herausforderungen anzupassen. Der Beitrag liefert eine Darstellung zum Umfang öffentlicher Investitionsbedarfe aus unterschiedlichen Sichtweisen (Finanzstatistik, volkswirtschaftliche Gesamtrechnungen, kommunale Doppik) und skizziert methodische Schwierigkeiten ihrer Erhebung. Er geht zudem der Frage nach, welche Rolle Befragungsergebnisse bei der Bestimmung notwendiger Investitionsvolumina spielen. Darüber hinaus werden empirische Einblicke in die Ursachen der Investitionsschwäche gegeben und die Folgen unzureichend ausgestatteter Infrastruktureinrichtungen thematisiert. Es wird einerseits evident, dass unabhängig vom methodischen Ansatz ein erheblicher ungedeckter Investitionsbedarf der Kommunen besteht, und andererseits, dass ein Instrumentenmix aus einer strukturellen Stärkung der kommunalen Steuereinnahmen, der Erleichterung von Sozialausgaben sowie einer Verstetigung und Vereinfachung von Förderprogrammen erforderlich ist, um die kommunalen Investitionen dauerhaft zu beleben.
Physical functioning in patients with end-stage knee osteoarthritis: A cross-sectional study in Jordan using self-reported questionnaire and performance-based tests
Authors: Abujaber Sumayeh , Altubasi Ibrahim , Hamdan Mohammad , Al-Zaben Raed , Bani-Ahmad Omar
Published: January 2024

BACKGROUND: Knee osteoarthritis (OA) is a debilitating condition that leads to functional limitations. Self-reported questionnaires and performance-based tests are tools commonly used for measuring physical function. OBJECTIVES: (1) To evaluate the impact of end-stage knee OA on functional outcomes and examine the association between self-reported and performance-based measures of function in patients with end-stage knee osteoarthritis awaiting total knee arthroplasty (2) To explore the interrelationships among pain, strength, and overall physical function in this patient population. METHODS: In this cross-sectional analysis, 33 patients with end-stage knee OA were recruited and completed the knee Outcome Survey-Activities of Daily Living Scale (KOS-ADLS) and executed performance-based tests including the Timed Up and Go, the 30-second chair stand test, and the Stair Climbing Test. Knee pain, and isometric hip and knee strength were evaluated. RESULTS: Patients perceived deficits in their physical functionwith a score of 35/100 on the KOS-ADLS and demonstrated functional limitations in all performed tasks. KOS-ADLs was weakly associated with TUG and 30s-CST (r=-0.301, p= 0.047, and r= 0.39, p= 0.014. respectively). Knee pain was linked with the KOS-ADL score and GRS score (r=-0.406, p= 0.010; r=-0.343, p= 0.027; respectively), while the strength of the affected side was correlated with the performed (p=< 0.001) and reported function outcomes (p= 0.007). CONCLUSION: Participants exhibit declines in both perceived and executed functional abilities. Self-reported and performance-based functional measures are weakly correlated within our study group, highlighting the importance of incorporating both measures in clinical practice for a comprehensive evaluation of physical function. Pain was linked to subjective aspect of physical function, while strength was connected to perceived and performed functional capacity. Implementing a tailored rehabilitation program targeting muscle weakness and pain holds the potential to mitigate functional decline in individuals awaiting total knee arthroplasty (TKA).
The Advent of the 2023 “BBNJ” Agreement: A Preliminary Legal Analysis
Authors: Ricard Pascale
Published: January 2024

On 4 March 2023, the Member States of the United Nations agreed in New York on the text of a new treaty on biodiversity in areas beyond national jurisdiction (BBNJ or ABNJ) –in international maritime areas. It took marathon process spread over more than ten years of informal discussions, four years of formal negotiations and the final session of almost 36 hours. Rena Lee, the President of the intergovernmental conference, announced to the applause of the delegates that the ship had finally “reached the shore”. This new BBNJ Agreement, now signed by more than 80 countries, is a historic step for the conservation and sustainable use of marine biodiversity of areas beyond national jurisdiction. It is also in consonance with the objectives of the global Kunming-Montreal Biodiversity Framework adopted at CBD COP15 in December 2022. This article aims to provide a preliminary analysis of the environmental (preamble, principles and approaches, area-based management tools and environmental impact assessments) and economic (marine genetic resources, capacity building and transfer of marine technologies) content of the 2023 BBNJ Agreement, which are both the result of important compromises. It also seeks to underline the numerous remaining uncertainties and potential difficulties it raises, especially in terms of implementation and articulation with existing instruments and frameworks.
The Ratio of Plasma Amyloid-β 1-42 over Serum Albumin Can Be a Novel Biomarker Signature for Diagnosing End-Stage Renal Disease-Associated Cognitive Impairment
Authors: Hou Yi-Chou , Chueh Ti-I , Lu Kuo-Cheng , Liu Yi-Chien , Chen Tso-Hsiao , Liu Shing-Hwa , Chen Ruei-Ming
Published: January 2024

Background: Cognitive impairment (CI) is one of the major complications in chronic kidney disease patients, especially those with end-stage renal disease (ESRD). Limited biomarkers have been found that can significantly predict ESRD-associated cognitive decline. Objective: This cohort study aimed to investigate de novo biomarkers for diagnosis of the ESRD-associated CI. Methods: In this cohort study, qualified samples were divided into control (with an estimated glomerular filtration rate (eGFR) of≥60 mL/min and a Mini-Mental State Examination (MMSE) score of > 27), ESRD without CI (eGFR < 15 and MMSE > 27), and ESRD with CI (eGFR < 15 and MMSE < 27) groups. Levels of plasma amyloid-β (Aβ)1 - 42, serum indoxyl sulfate, and hematologic and biochemical parameters were measured. Results: Compared to the control group, levels of blood urea nitrogen, creatinine, and indoxyl sulfate were elevated in ESRD patients both without and with CI. Interestingly, ESRD patients with CI had the lowest levels of serum albumin. In contrast, levels of plasma Aβ1 - 42 were significantly higher in the ESRD with CI group than in the control and ESRD without CI groups. In addition, the ratio of plasma Aβ1 - 42 over serum albumin was significantly higher in the ESRD with CI group than in the control or ESRD without CI groups. Importantly, the area under the receiver operating characteristic curve (AUROC) for CI in the total population by the ratio of Aβ1 - 42 over albumin was 0.785 and significant (p < 0.05). Conclusions: This cohort study has shown that the ratio of plasma Aβ1 - 42 over serum albumin can be a de novo biomarker for the diagnosis and prognosis of ESRD-associated cognitive decline.
The Standardized Extract of Centella asiatica and Its Fractions Exert Antioxidative and Anti-Neuroinflammatory Effects on Microglial Cells and Regulate the Nrf2/HO-1 Signaling Pathway
Authors: Hambali Aqilah , Jusril Nor Atiqah , Md Hashim Nur Fariesha , Abd Manan Nizar , Adam Siti Khadijah , Mehat Muhammad Zulfadli , Adenan Mohd Ilham , Stanslas Johnson , Abdul Hamid Hafizah
Published: January 2024

Background: Neuroinflammation and oxidative stress can aggravate the progression of Alzheimer’s disease (AD). Centella asiatica has been traditionally consumed for memory and cognition. The triterpenes (asiaticoside, madecassoside, asiatic acid, madecassic acid) have been standardized in the ethanolic extract of Centella asiatica (SECA). The bioactivity of the triterpenes in different solvent polarities of SECA is still unknown. Objective: In this study, the antioxidative and anti-neuroinflammatory effects of SECA and its fractions were explored on lipopolysaccharides (LPS)-induced microglial cells. Methods: HPLC measured the four triterpenes in SECA and its fractions. SECA and its fractions were tested for cytotoxicity on microglial cells using MTT assay. NO, pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), ROS, and MDA (lipid peroxidation) produced by LPS-induced microglial cells were measured by colorimetric assays and ELISA. Nrf2 and HO-1 protein expressions were measured using western blotting. Results: The SECA and its fractions were non-toxic to BV2 microglial cells at tested concentrations. The levels of NO, TNF-α, IL-6, ROS, and lipid peroxidation in LPS-induced BV2 microglial cells were significantly reduced (p < 0.001) by SECA and its fractions. SECA and some of its fractions can activate the Nrf2/HO-1 signaling pathway by significantly enhancing (p < 0.05) the Nrf2 and HO-1 protein expressions. Conclusions: This study suggests that the inhibitory activity of SECA and its fractions on pro-inflammatory and oxidative stress events may be the result of the activation of antioxidant defense systems. The potential of SECA and its fractions in reducing neuroinflammation and oxidative stress can be further studied as a potential therapeutic strategy for AD.
Substantial Doubt Remains about the Efficacy of Anti-Amyloid Antibodies
Authors: Digma Leonardino A. , Winer Joseph R. , Greicius Michael D.
Published: January 2024

With the FDA approval of aducanumab and lecanemab, and with the recent statistically significant phase 3 clinical trial for donanemab, there is growing enthusiasm for anti-amyloid antibodies in the treatment of Alzheimer’s disease. Here, we discuss three substantial limitations regarding recent anti-amyloid clinical trials: 1) there is little evidence that amyloid reduction correlates with clinical outcome, 2) the reported efficacy of anti-amyloid therapies may be explained by functional unblinding, and 3) donanemab had no effect on tau burden in its phase 3 trial. Taken together, these observations call into question the efficacy of anti-amyloid therapies.
Probability numbers for multi-attribute decision-making
Authors: Weng Shizhou , Huang Zhengwei , Lv Yuejin
Published: January 2024

In the face of increasingly complex data forms and decision-making problems, the uncertainty of information poses a major challenge to multi-attribute decision-making methods. How to effectively organize information and serve realistic decision-making problems has attracted extensive attention in the academic circles. In view of this, based on the distribution law of random variables, we put forward the basic concept of probability numbers and construct a general framework, including the concepts of type, order, item, isomorphism and isomerism, same domain and same distribution of probability numbers. On this basis, we further define the expectation and variance formula of probability numbers, and its operation rules are defined for the same type of probability numbers. To compare the dominance and inferiority of probability numbers further accurately, we put forward the concepts of dominance degree and comparability degree of probability numbers, so that decision makers can realize the ranking of probability numbers by calculating the comprehensive dominance degree. In view of the related concepts of probability numbers, we summarize the properties and theorems of probability numbers and prove them. In addition, a probability numbers-based multi-attribute decision-making framework model is proposed to solve the multi-attribute decision-making problem. Decision makers can select appropriate sub-models to construct personalized multi-attribute decision-making methods according to actual needs. At the end of the paper, we apply the method to the multi-attribute decision case of campus express stations evaluation and verify the scientificity and rationality of the evaluation method. The concept of probability numbers and its decision model proposed in this paper extend the concept category of numbers, enrich the multi-attribute decision-making method based on probability numbers, and have certain reference significance for further research of uncertain decision theory and method.
A many-to-many matching method considering priority for shared private idle parking spaces and demanders
Authors: Jiang Yanping , Tang Zhenpeng , Song Xinchao , Shao Xinran
Published: January 2024

There has been widespread and growing concern about parking. This paper attempts to provide decision support for a shared parking system to reduce parking difficulty. We study a many-to-many matching problem between shared private idle parking spaces and their demanders. A novelty is that the demanders are allowed to use different parking spaces successively in parking relocation service support. This can further reintegrate the idle time of the parking spaces and improve their utilization rate. A multi-objective optimization model is constructed to maximize the number of matched demanders, the total priority of the parking spaces, and the total priority of the demanders. More importantly, the priorities of the parking spaces and the demanders are innovatively considered. Each of the parking spaces and the demanders is given a priority for the matching and the priority of a parking space or a demander will be increased if the parking space or demander rarely gets matched successfully. This helps reduce the withdrawal of parking spaces and the demanders from the parking platform. In addition, an NSGA-II algorithm is designed to solve the model efficiently. Finally, the feasibility of the proposed method is illustrated via an example.
Influencing factor analysis and enterprise evaluation of lithium-ion battery recycling based on improved DEMATEL method
Authors: Wang Daiwen , Sun Jie , Wei Cuiping
Published: January 2024

Spent lithium-ion battery (LIB) recycling can create great pollution to the environment. Understanding the safety, environment, technique, and regulation factors’ impact on the recycling process is crucial. Due to the complexity of the relevant factors, and there is a certain degree of correlation and dependence between the factors, the Decision Making Trial and Evaluation Laboratory (DEMATEL) method is used to analyze the factors’ degree of impact in this study. As the experts are ambiguous about some relations between the factors, it is impossible to conduct integrated evaluation. The improved DEMATEL method is proposed in this study to make up the missing relations. Further, the weights of the factors will be calculated. In the improved DEMATEL method, the numerical scale of a linguistic term set is introduced. Therefore, the numerical scale used by experts can not only be uniform and symmetrical, but can also be non-uniform symmetric, non-uniform asymmetric, etc. Finally, both reusing and recycling companies are included in this study and their factors’ importance weights were analyzed with the fuzzy comprehensive evaluation method.
Cognitive task analysis-driven intelligent steering wheel interaction design
Authors: You Fang , Li Yaru , Fu Qianwen , Zhang Jun
Published: January 2024

With the increasing levels of intelligence and automation, the relationship between humans and vehicles has evolved from a utilitarian perspective to a partnership. Among the crucial factors for enhancing user experiences are the analysis of driving tasks, the construction of user needs models, and the design of intelligent interfaces. Based on this background, this paper proposes a cognitive task analysis model using intelligent steering wheel information interaction design as the vehicle. The model aims to extract key design elements to assist designers in making design decisions, thereby improving the human-machine cooperation performance of intelligent automobiles and enhancing user perceptual experiences. Firstly, within the context of human-machine cooperation systems, a cognitive task analysis method integrating the SRK model is proposed. By analyzing the behavioral decision characteristics between the vehicle and the user, a framework for the human-machine interface (HMI) logic of the steering wheel and a dynamic layout prototype are established. Secondly, the design of the steering wheel’s HMI interaction is based on an analysis of users’ affective needs and rational physiological characteristics. This paper integrates the analysis of users’ affective needs to identify design elements that align with a high level of user satisfaction. Lastly, the design methodology model is applied to a navigation scenario, resulting in the creation of a steering wheel HMI prototype within a human-machine cooperation system. The prototype is then subjected to a combined subjective and objective experimental analysis, thereby validating the superiority of the steering wheel HMI’s detection indicators over those of the central control HMI and establishing the design pattern for the steering wheel HMI.
Interaction and risk preference-based group decision-making with intuitionistic fuzzy preference relations
Authors: Wei Ying , Gong Kaixin , Chen Chunfang , Zhu Xianghong
Published: January 2024

This research proposes a new method to solve group decision-making(GDM) problems with intuitionistic fuzzy preference relations(IFPRs). First, a new definition of multiplicative consistency of IFPR is presented to address the defects of the existing consistency definitions. Then, two programming models are established to obtain the most optimistic and pessimistic consistent IFPRs and corresponding intuitionistic fuzzy priority weights. Also, in order to improve the accuracy of aggregate information, a new method to determine the weights of decision-makers(DMs) is offered by considering the interaction among DMs. Subsequently, by combining the vagueness and non-vagueness of the aggregated information, a multiplicative consistency definition of the collective IFPR is provided. Moreover, to simplify the GDM process, a programming model for solving the priority weight is established, which effectively avoids the consistency test and correction of IFPRs. Finally, the values of the proposed method are illustrated by comparative analysis.
A communication link lifetime prediction-supported V2V partial computation offloading scheme for autonomous driving
Authors: Men Rui , FAN Xiumei , Yan Jun , Shan Axida , Fan Shujia
Published: January 2024

Vehicle Edge Computing (VEC) is a promising technique to improve the quality of service (QoS) and quality of experience (QoE) in autonomous driving by exploiting the resources at the network edge. However, the high mobility of the vehicles leads to stochastic communication link duration, and the tasks generated by various applications in autonomous driving incur fierce competition for resources. These challenges cause excessive task completion delays. In this paper, we propose a vehicle-to-vehicle (V2V) partial computation offloading scheme that leverages the prediction results of the communication link lifetime between vehicles. A History track, Current interactions and Future planning trajectory-aware Gated Recurrent Units (HCF-GRU) network is built to capture the essential factors to improve the prediction accuracy. Then, we design a GRU-based Proximal Policy Optimization (GRU-PPO) algorithm to obtain an optimal one-to-many offloading decision to minimize the task execution cost. The HCF-GRU prediction algorithm is evaluated on a real world vehicle trajectory dataset, and the performance of the GRU-PPO algorithm is analyzed on extensive numerical simulations. Experimental results demonstrate that our prediction network and offloading decision algorithm outperform the baseline methods in terms of prediction accuracy and task execution cost.
The Importance of Digital Health Literacy in an Evolving Parkinson’s Disease Care System
Authors: Esper Christine D. , Valdovinos Blanca Y. , Schneider Ruth B.
Published: January 2024

Digital health technologies are growing at a rapid pace and changing the healthcare landscape. Our current understanding of digital health literacy in Parkinson’s disease (PD) is limited. In this review, we discuss the potential challenges of low digital health literacy in PD with particular attention to telehealth, deep brain stimulation, wearable sensors, and smartphone applications. We also highlight inequities in access to digital health technologies. Future research is needed to better understand digital health literacy among individuals with PD and to develop effective solutions. We must invest resources to evaluate, understand, and enhance digital health literacy for individuals with PD.
A Phase I, Randomized, SAD, MAD, and PK Study of Risvodetinib in Older Adults and Parkinson’s Disease
Authors: Werner Milton H. , Olanow C. Warren , McGarry Andrew , Meyer Christopher , Kruger Sydney , Klint Carl , Pellecchia Jacqueline , Walaker Shannon , Ereshefsky Larry , Blob Lawrence , Hassman Howard , Rodriguez Carlos , Samara Emil , Safirstein Beth , Ellenbogen Aaron
Published: January 2024

Background:

Pre-clinical studies suggest that c-Abl activation may play an important role in the etiology of Parkinson’s disease, making c-Abl an important target to evaluate for potential disease-modification.

Objective:

To assess safety, tolerability, and pharmacokinetics of the c-Abl inhibitor risvodetinib (IkT-148009) in healthy subjects and participants with Parkinson’s disease.

Methods:

Part 1 (single ascending dose (SAD)) and Part 2 (7-day multiple ascending dose (MAD)) studies were in healthy volunteers. Participants were randomized 3 : 1 across 9 SAD doses and 3 MAD doses of risvodetinib (IkT-148009) or placebo. Part 3 was a MAD study conducted at two doses in 14 participants with mild-to-moderate PD (MAD-PD). Primary outcome measures were safety, tolerability and pharmacokinetics. Exploratory outcomes in PD participants included clinical measures of PD state, GI function, and cerebrospinal fluid (CSF) concentration.

Results:

108 patients were treated with no dropouts. The SAD tested doses ranging from 12.5 to 325 mg, while the MAD tested 25 to 200 mg and MAD-PD tested 50 to 100 mg in Parkinson’s participants. All active doses had a favorable safety profile with no clinically meaningful adverse events. Single dose pharmacokinetics were approximately linear between 12.5 mg and 200 mg for both Cmax and AUC0 - inf without distinction between healthy volunteers and participants with PD. Exposures at each dose were high relative to other drugs in the same kinase inhibitor class.

Conclusions:

Risvodetinib (IkT-148009) was well tolerated, had a favorable safety and pharmacology profile over 7-day dosing, did not induce serious adverse events and did not appear to induce deleterious side-effects in participants administered anti-PD medications.
Complete blood count inflammation derived indexes as predictors of metabolic syndrome in type 2 diabetes mellitus
Authors: Fajkić Almir , Jahić Rijad , Begić Edin , Dervišević Amela , Kurtović Avdo , Lepara Orhan
Published: January 2024

BACKGROUND: Metabolic syndrome (MetS) is a group of comorbidities related to regulating hyperglycemia and acute cardiovascular incidents and complications. With the increasing prevalence in individuals with type 2 diabetes mellitus (T2DM), MetS represents an increasing public health problem and clinical challenge, and early diagnosis is necessary to avoid the accelerated development of diabetic complications. OBJECTIVE: To investigate the role of Complete Blood Count-derived Inflammation Indexes (CBCIIs) in predicting MetS in T2DM individuals. METHODS: The study was designed as a two-year prospective study and included 80 T2DM individuals divided into MetS and non-MetS groups based on MetS development over two years. The sera samples were analyzed for complete blood count parameters and C-reactive protein (CRP). Based on the laboratory test results, 13 CBCIIs were calculated and analyzed. The receiver operating characteristic (ROC) curve and their corresponding areas under the curve (AUC) were used to determine prognostic accuracy. RESULTS: There were significant differences between T2DM participants with Mets and those without MetS concerning Neutrophil to Platelet Ratio (NPR) values (p< 0.001), Neutrophil to Lymphocyte and Platelet Ratio (NLPR) (p< 0.001), Platelet to Lymphocyte Ratio (PLR) (p< 0.001), Lymphocyte to C-reactive protein Ratio (LCR) (p< 0.001), C-reactive protein to Lymphocyte Ratio (CRP/Ly) (p< 0.001), Systemic immune inflammation index (SII) (< 0.001), and Aggregate Index of Systemic Inflammation (AISI) (p= 0.005). The results of ROC curve analysis have shown that the LCR (AUC of 0.907), CRP/Ly (AUC of 0.907) can serve as excellent predictors, but NPR (AUC of 0.734), NLRP (AUC of 0.755), PLR (AUC of 0.823), SII (AUC of 0.745), and AISI (AUC of 0.688) as good predictors of MetS in T2 DM individuals. CONCLUSION: This study confirms the reliability of the CBCIIs as novel, simple, low cost and valuable predictors of MetS developing in T2DM.
NOP16 promotes hepatocellular carcinoma progression and triggers EMT through the Keap1-Nrf2 signaling pathway
Authors: Mu Shangdong , Tian Qiusi , Shen Liangyu
Published: January 2024

BACKGROUND: Nucleolar protein 16 (NOP16) is present in the protein complex of the nucleolus. The NOP16 promoter contains a c-Myc binding site, and the transcriptional regulation by c-Myc directly regulates NOP16 expression levels. OBJECTIVE: Dysregulation of NOP 16 is currently reported in only a small number of cancers. In this study, the expression profile of NOP 16 in hepatocellular carcinoma (LIHC) and its clinical significance were analyzed. METHODS: NOP16 expression in hepatocellular carcinoma (LIHC) and its relationship with the clinical characters of LIHC were examined using the Cancer Genome Atlas (TCGA), the Gene Expression comprehensive database (GEO), Kaplan-Meier survival analysis, univariate Cox analysis, multivariate Cox analysis, ROC curve analysis of KEGG enrichment, GSEA enrichment, in vitro experiments (e.g., siRNA interference of NOP16 expression in hepatoma cells, Keap1-Nrf2 pathway, cell cycle, cell apoptosis and Transwell assays), and LIHC single-cell sequencing (scRNA). RESULTS: Pan-cancer analysis revealed that NOP16 was highly expressed in 20 cancer types, including LIHC, and high NOP16 expression was an independent adverse prognostic factor in LIHC patients. The expression levels of NOP16 mRNA and protein were significantly increased in tumour tissues of LIHC patients compared to normal tissues. The functions of co-expressed genes were primarily enriched in the cell cycle and reactive oxygen species metabolism. The experimental results showed that knockdown of NOP16 activated the Keap/Nrf2 signalling pathway and inhibited the invasion, migration, and EMT progression of LIHC cells. LIHC scRNA-seq data showed that NOP16 was primarily expressed in T lymphocytes. CONCLUSIONS: NOP16 promoted cancer development in LIHC and caused an imbalance in Keap/Nrf2 signalling, which subsequently caused the aberrant expression of genes typical for EMT, cell cycle progression and apoptosis. NOP16 is a potential prognostic marker and therapeutic target for hepatocellular carcinoma progression.
The use of a modern robotic system for the treatment of severe knee deformities
Authors: Rossi Stefano Marco Paolo , Sangaletti Rudy , Andriollo Luca , Matascioli Luca , Benazzo Francesco
Published: January 2024

BACKGROUND: Robotic-assisted total knee arthroplasty (TKA) have shown promising results in recent years with improved clinical outcomes using standard primary implants. OBJECTIVE: The purpose of this study was to assess the experience of a single center in correcting severe coronal deformities with the use of a robotic-assisted TKA system and an increased constrained implant. METHODS: Between July 2020 and December 2022, 30 knees in 28 patients with a major deformity and an associated ligament laxity requiring an increased constrained implant treated using an imageless robotic-assisted TKA were prospectively enrolled. Patients included in the study showed a minimum 15 degrees varus or 10 degrees valgus deviation. RESULTS: 20 cases were varus knees and 10 cases were valgus knees. Postoperative neutral alignment was defined as 0∘± 2.5∘. A CCK implant was used in 20 cases while a Constrained Posterior Stabilized implant was used in 10 cases. A neutral alignment was achieved in all patients. At a minimum 6 months follow up (f-u 6–30 months) clinical outcomes including ROM, KSS, HSS, OKS and WOMAC showed significant improvement and no major complications were registered. CONCLUSIONS: The robotic system showed the achievement of a mechanical alignment with reliable radiographic outcomes and clinical results in the treatment of major deformities of the lower limb with the use of higher constrained implants at short term follow up. Further follow up and studies are necessary to confirm and verify these promising outcomes.
How do babies roll? Identifying the coordinated movements of infant rolling through video compared to laboratory techniques
Authors: Siegel Danielle N. , Ogle Melissa M. , Wilson Christopher , Scholes Olivia , Prow Abby , Mannen Erin M.
Published: January 2024

BACKGROUND: Rolling is an important developmental milestone for infants where identifying the coordinated movement patterns could facilitate the early identification of motor development delays. Current methods for identifying coordinated movements of rolling are limited to a laboratory setting and not feasible for clinicians. OBJECTIVE: To develop video-based methods in which six coordinated movements, previously defined through motion capture, can be identified through video alone. METHODS: Forty-five videos of sixteen healthy infants achieving a roll were used to develop the video-based methodology and twenty-four videos had corresponding motion capture data used for validation. Four raters comprised of researchers and a clinician identified rolling coordination using the new video-based methods. A Fleiss’ Kappa statistical test determined the inter- and intra-rater reliability of agreement for the new methodology and compared it to motion capture. RESULTS: The comparison of the motion capture and video-based methods resulted in substantial agreement. The video-based methods inter- and intra-rater reliability were substantial and almost perfect, respectively. CONCLUSIONS: We developed reliable methodology to accurately identify the coordinated movements of infant rolling using only 2D video. This methodology will allow researchers to reliably define coordinated movements of infants through video alone and may assist clinicians in identifying possible motor development delays and disorders.
Pengembangan E-Modul Flipbook Berbasis Problem Based Learning untuk Siswa SMA pada Materi Pencemaran Lingkungan
Authors: Wahyuni Ni Wayan Anggi Sri , Citrawathi Desak Made , Heny Ajeng Purnama
Published: January 2024

Penelitian ini memiliki tujuan untuk mengetahui tingkat validitas dan kepratisan e-modul untuk pembelajaran biologi pada pokok bahasan pencemaran lingkungan di SMA Negeri 1 Bebandem. Jenis penelitian yang dilakukan adalah penelitian dan pengembangan (Research and Development) menggunakan model pengembangan 4D yang dimodifikasi terdiri dari tahap Define, Design, Development. Penelitian dilaksanakan denga menyebar lembar penilaian kepada para ahli, guru biologi dan peserta didik. Data hasil penelitian kemudian dianalisis menggunakan rumus uji validitas dan uji kepraktisan. Berdasarkan hasil analisis data dan pembahasan pada uji validitas didapat rerata persentase sebesar 90% Artinya e-modul yang dikembangkan sudah sangat valid untuk digunakan dalam proses pembelajaran. Hasil analisis data dan pembahasan pada uji praktikalitas mendapat rerata 88,14%. Artinya e-modul yang dikembangkan sudah sangat praktis untuk digunakan dalam kegiatan pembelajaran. 

Kata kunci: E-modul, Pencemaran Lingkungan, Problem Based Learning, Research and Development (R&D)
Kedudukan dan Hikmah Mahar dalam Perkawinan
Authors: Maki Leo Perkasa
Published: January 2024

The dowry (mahr) is a significant element in the marriage contract, holding a distinct position in Islamic law. This study aims to analyze the position of the dowry in marriage and uncover the wisdom behind its provision. Using a normative-juridical approach and literature review, this research explores the legal basis of the dowry in the Qur'an, Hadith, and opinions of Islamic scholars. The study also highlights the social and religious implications of the dowry, including its role as a symbol of respect for women and as a form of the husband's responsibility. The findings indicate that the dowry is not merely a material gift but carries deep spiritual and social meanings, serving to strengthen the marital bond and protect the rights of the wife. The dowry also reflects the husband's responsibility in ensuring the welfare of his family. In conclusion, the dowry's position in marriage is highly significant from both Islamic legal and societal perspectives, and its provision holds broad wisdom for both parties in marriage.
Kesesuaian antara Fatwa Yusuf Qardhawi dan Kompilasi Hukum Islam terkait Wali Mujbir dan Wali Nikah
Authors: Yusrizal Navis
Published: January 2024

There are divisions, friction and disagreements in the household that reach the divorce line. Usually, these things are caused by incompatibility between the husband and wife; one of the causes is forced marriage or mujbir guardian. Ulama also has different opinions regarding the marriage guardian and the mujbir guardian. This research examines Yusuf Qardhawi's fatwa and its relevance to KHI. There are three formulations for this research, namely: What is Yusuf Qardhawi's view of mujbir guardian and marriage guardian? and what is their relevance to KHI? the method researchers chose here is library research with a qualitative approach. Data sources include primary data from Yusuf Qardhawi's fatwa and KHI. Meanwhile, secondary data is in fiqh books, journals and others. From the analysis that the author has carried out, Yusuf Qardhawi rejects the opinion that allows guardians forced on girls because several hadiths require consultation with girls when they want to get married, so the sign is that they are not allowed to marry without their consent, and also have to look at the historical framework in Imam Syafi'i's era where women did not have the ability to choose a partner, is different from this era where women's education is equal to that of men. Yusuf Qardhawi's opinion is relevant to KHI article 16, paragraph 1. Yusuf Qardhawi also allows marriage without a guardian, as is Hanafi opinion; this is not relevant to KHI in article 14, which makes the guardian one of the pillars.
The FLRW Geometries and the Expansion of Space
Authors: Aaberge Terje
Published: January 2024

The usual presentation of the FLRW geometries is given in coordinates that makes it difficult to assess the nature of the expansion of space for these geometries. There exists, however, alternative representations defined by a (canonical) diffeomorphism that introduces coordinates giving more accessible descriptions. The paper presents these coordinates and in addition similar geometries which appear as natural alternatives to the FLRW geometries. The two kinds of geometries give the same description of the evolution of the universe for the period of which we have empirical information. A number of consequences of this observation is presented for the spherical model.
SnakeChat: a conversational-AI based app for snake classification
Authors: Guerra Pires Jorge
Published: January 2024

Conversational Artificial Intelligence (CAI) was the latest big step towards artificial general intelligence (AGI): models of AI that are generic, that can solve problems without being restricted to a small set of problems they were designed for. OpenAI with chatGPT gave a big step towards this direction. On the other hand, being able to classify snakes from images can help the general public, and even experts to classify snakes (e.g., finding the right snake serum). There are more than 2.000 different species of snakes worldwide. On this paper, we explore the latest releases of openAI APIs. We integrate with a previous work we did, using transfer learning to classify snakes. We have used their GPT Vision API for describing uploaded images textually, their latest chatGPT API for deciding which model to use for classifying an image and also to generate a human-friendly final textual response. Additionally, we also tested their GPT 4 API instead of the chatGPT API as a comparison. We found that the integration was a success. By giving our models to openAI API, it decides which model to call as so it could give an educated guess to the user based on an uploaded image from the snake. The best result was when we used the GPT 4 API, something we already expected. We hope that this prototype can be scaled up with more species. We did a test of concept, and showed that the basics needed to build such a system for snake classification is possible with current technologies. We hope to contribute to sparking research that brings together computer scientists and biologists, generally called bioinformatics.