bluuebunny/crossref_metadata_2025 huggingface dataset:
Olaudah Equiano’s Biography: Fact or/and Fiction
Authors: Matiu Ovidiu
Published: February 2023

This article analyzes the documentation available in an attempt to settle the controversy over the “true” date and place of birth of Olaudah Equiano, or Gustavo Vassa, the African. Several original documents are analyzed, and the data is compared to the information provided by the author himself in his The Interesting Narrative of the Life of Olaudah Equiano, or Gustavus Vassa, the African. Written by Himself, first published in London, in 1789. According to these documents (a baptismal record and a muster book), he was not born in Africa, in Igboland (in today’s Nigeria) as he argued in his autobiography, but in South Carolina, as he declared before those who recorded the information in the official documents. The issue of authenticity is more relevant for historical research than for literary criticism; in the case of the latter, the accuracy of the data does not significantly impact upon the literary value of his work. In conclusion, the dispute is pertinent only in the liminal space where the two contexts (historical research and literary analysis) overlap, and it currently operates with information whose relevance and usefulness depend on the framework against which it is judged.
Memories of Immigrant Life: Marie Jastrow’s A Time to Remember: Growing Up in New York before the Great War (1979)
Authors: Iancu Anca-Luminița
Published: February 2023

In her coming-of-age memoir, A Time to Remember: Growing Up in New York before the Great War (1979), Marie Jastrow, a Jewish-American immigrant woman, cleverly captures the daily life of her family in Yorkville, New York City, in the early decades of the twentieth century. Jastrow recalls the difficulties she and her parents had to face during their first years in the United States, between 1907 and 1918, and the ways in which they managed to adapt to the social, economic, political, and cultural circumstances of the new environment. Therefore, this essay sets out to explore how Jastrow’s family members succeeded in negotiating the challenges of a gendered immigrant experience.
A “Cold Case” Of Neonatal Death In Italy: A Fulfilling Prophecy or A Lesson Not Learnt?
Authors:   1Department of Neurology, Ophthalmology, Genetics, Mother and Infant Sciences, Medicine School University of Genoa, Genoa, Italy, Morano Sandra , Calleja-Agius Jean ,   2Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
Published: February 2023

In Italy, there was a recent great uproar in the aftermath of the tragedy of a 3 day-old newborn, who died in Pertini Hospital in Rome while rooming in and sleeping right next to the mother, and was reported by the media as having suffocated. There is surmounting evidence in the literature highlighting how the human major life events of birth in health systems have regressed to “dehumanizing” childbirth practices [6,7]. This is aggravated by the budget cuts and dire shortage of healthcare workers, that has negatively impacted the effectiveness of healthcare services. The decline in healthcare systems is mainly reflected by the lack of adequate perinatal care due to the widespread elimination of most of the psychosocial and ethical achievements in perinatal care that had been developed and attained in the last decades. This very critical issue does matter as well to caregivers, and in particular researchers and clinicians. Hundreds of research works, papers and reports, as well as many European projects, could risk to appear quite useless if they do not result in voices heard by the whole society, starting from the scientific community, patient advocacy groups, policy makers, managers, and so on. As women, clinicians and mothers, we understand now more than ever the real lesson of the pandemic: a mandatory change in childbirth culture, spaces and practices.
¿Brecha de “desigualdad de origen” en el sistema de admisión a nivel de pregrado de la Universidad Surcolombiana?
Authors: Rozo Vanegas Natalia
Published: February 2023

La sentencia T-441-1997 marca un cambio de paradigma respecto al conjunto determinado de comunidades que tienen un trato especial en los sistemas de admisión a la educación superior. Pues afirma que, la población proveniente de zonas marginadas también deben ser sujetos de trato especial, ante la “desigualdad de origen” que se configura al presentar las pruebas de admisión; ya que estas, a pesar de establecer igualdad de condiciones, no garantizan que todos gocen de las mismas oportunidades, debido a las desigualdades existentes en la calidad de la educación pública y privada del país.

Mediante un enfoque analítico-descriptivo apoyado en un método mixto, se analizó el sistema de admisión al nivel de pregrado de la universidad Surcolombiana y la población admitida mediante este, desde dos factores incidentales en la configuración de las zonas marginadas: la naturaleza oficial o privada de la institución de educación media y el estrato socioeconómico de los aspirantes admitidos. Esto con el fin de determinar si existen brechas de desigualdad en el sistema de admisión con respecto a las comunidades que se encuentra en un mayor olvido estatal.

El estudio encuentra que, aunque a nivel general predominan los admitidos provenientes de instituciones de educación media oficial y de bajo estrato socioeconómico; existe una naciente brecha de “desigualdad de origen” en los programas académicos que exigen altos puntajes para ingreso, y que tienen un mejor pago en el mercado laboral. Pues se evidencia, una nivelación e incipiente dominio numérico de los admitidos provenientes de instituciones de educación media privada sobre los de instituciones públicas. Lo que podría deberse a que, los aspirantes de estratos altos y de colegios privados tienen más opción de ganar un cupo, debido a la calidad de su preparación académica en comparación con aspirantes de colegios oficiales urbanos o rurales y de estratos bajos.
Racismo, blanquidad y privilegios raciales como categorías en disputa durante la coyuntura del paro nacional 2021, Colombia
Authors: Cortés Verónica
Published: February 2023

Este artículo explora de manera multiacentual el racismo, la blanquidad y los privilegios raciales como categorías en disputa durante la coyuntura del paro nacional 2021. Al mismo tiempo, se problematiza el racismo como categoría analítica necesaria pero insuficiente para abordar las experiencias de los privilegios raciales, en cuanto ventajas que conllevan la desigualdad, en una determinada coyuntura. Por ello, propone una mirada desde la blanquidad como una estructura configuradora de las formaciones sociales a partir de una (re)lectura de lo sucedido con la Minga Indígena y los habitantes de Ciudad Jardín, así como también del abuso racializado de la fuerza estatal en Siloé (dos barrios de la ciudad de Cali, Colombia). Con esto, la apuesta entonces es por visibilizar cómo la blanquidad y los privilegios raciales comprenden una suerte de no desigualdades estructurales para unos sujetos en menoscabo de otros.
Skład chemiczny i aktywność biologiczna Laetiporus sulphureus (Bull.)
Authors: Szymański Marcin , Kolendowicz Marta , Szymański Arkadiusz
Published: February 2023

Laetiporus sulphureus is a species of fungus commonly found all over the world. Its fruiting bodies are most often found on deciduous trees and very rarely on conifers. It is a dangerous pathogenic fungus that causes the death of infected trees. The fruiting bodies of the fungus contain, among others: polysaccharides, lectins, polysaccharide-protein complexes, lipids, triterpenes and phenolic compounds that exhibit antibacterial, antifungal, anti-inflammatory, anti-tumor, immunomodulating and hypoglycemic properties.
ПРОБЛЕМИ ДИФЕРЕНЦІАЦІЇ ПОНЯТЬ «МОВА» ТА «ДІАЛЕКТ» В УКРАЇНСЬКОМУ СОЦІОЛІНГВІСТИЧНОМУ ПРОСТОРІ
Authors: САВЧИН Тетяна
Published: February 2023

У статті ми намагаємося визначити сучасні погляди на диференціацію понять «мова» та «діалект». Відмінність між загальнолітературною мовою та діалектами демонструємо на підставі лексичних та регіональних особливостей. В сучасному українському науковому дискурсі питання розрізнення мови та діалекту є недостатньо дослідженим, тобто науковці досі не дійшли згоди у питаннях їх чіткого виокремлення. Мовознавці дійшли згоди, що загальнолітературну мову вирізняють усталеність, кодифікованість, зрозумілість для усіх носіїв мови. Літературна мова – це мова освіти, науки, медійних засобів тощо. Діалект має певні риси у лексичній , фонетичній, граматичній системі та є зрозумілим лише для певного регіону чи групи людей. На даний момент в Україні існує дійсно велика кількість діалектів і кожен із них має свої особливості формування, функціонування, побутування на певній території. Найбільше суперечок в українській соціолінгвістиці точаться навколо закарпатського говору, який слід вважати одним із діалектів сучасної української мови.

У статті детально розглядається проникнення діалектного мовлення у літературний твір, що, з одного боку надає авторському мовленню місцевої специфіки, а з іншого – сприяє входженню певних рис діалектного мовлення у загальноукраїнський мовленнєвий фонд. На властивість діалектів впливати на літературний текст звернув увагу ще Іван Франко. Найцікавішими щодо вживання діалектизмів є твори М. Коцюбинського, Ю. Федьковича, М. Павлика, Д. Харов’юка, М. Козоріса, Д. Павличка, Д. Бедзика. Найцікавішими прикладами вживання діалектизмів у сучасних літературних текстах вважаємо твори Володимира Лиса, Юрія Винничука, Марії Матіос.

Серед цікавих явищ взаємодії діалектів та літературної мови є ділінгвізм –володіння літературною мовою та однією з діалектних форм спілкування. Діалекти збагачуюють мовлення, розширюють літературний канон, стають своєрідною візитівкою освіченої та лінгвістично обдарованої людини.
PRÓBA WSTĘPNEJ KLASYFIKACJI LEKSYKALNYCH REALIZACJI POJĘCIA PTAK W WYPOWIEDZENIACH WYRAŻAJĄCYCH WIERZENIA I PRZESĄDY: FUNKCJONALNE I PRAGMATYCZNE KLASY
Authors: КЛИМЕНКО Дмитро
Published: February 2023

W artykule omówiono wybrane zagadnienia wstępnej klasyfikacji leksykalnych realizacji pojęcia ptak. Klasyfikacja, jako przejaw kategoryzacji pojęć, osadzona w świadomości zwyczajowo-mitologicznej zbiorowego podmiotu ludowego. Ona wpłynęła na procesy myślenia i następnie na kształtowanie oceny kulturowej w mowie i języku, przejawiającej się w tekstach o pragmatyce nie tylko mitycznej, ale również poznawczej lub magicznej. W artykule założono, że pojęcie ptak pełni w myśleniu człowieka dwie funkcje: funkcję semantyczną znaku oraz funkcję obiektu semiotycznego w wypowiedziach, wyrażających wierzenia i przesądy. Celem pracy jest analiza leksykalnych realizacji pojęcia ptak w doświadczeniu człowieka, polegająca na wyodrębnieniu funkcjonalnych i pragmatycznych klas w ramach kategoryzacji oraz uzasadnienia funkcji pojęcia ptak w ramach semantyki tekstów źródłowych. Teoretyczne zadanie dotyczyło określenia relacji przestrzeni kognitywnej pojęcia ptak, rozumianego jako część wymienionych w artykule, bardziej kompleksowo zorganizowanych przestrzeni kognitywnych ludzkiej codzienności. Materiałem do badań posłużyły teksty gatunków folklorystyczno-słownych – wierzeń i wypowiedzi przesądnych, z wybranych słowników, poświęconych ludowej tradycji ustnej, w których została utrwalona leksykalna realizacja pojęcia ptak. W artykule został dokonany przegląd rozważań dotyczących filozofii oraz psychologii oraz niektórych lingwosemiotycznych aspektów mowy. Zastosowana w pracy metodologia pragmatyzmu funkcjonalnego, ze względu na zasadę antropocentryczną, pozwala dokonać zarówno próby określenia głównych zasad kategoryzacji lingwosemitycznej podmiotu, jak i analizy modeli pojęć o ptaku, rozpatrywanych w ramach doświadczenia mownego. Zaprezentowane oceny funkcji i pragmatyki pojęcia ptak są sposobem wyrażenia w gatunkach folklorystycznych innych pojęć kulturowych z obszaru codzienności człowieka. Analiza leksykalnej realizacji pojęcia pozwala nam prześledzić zjawiska folklorystyczne, stanowi próbę uporządkowania klas funkcjonalnych i pragmatycznych pojęcia, lezących u podstaw obyczajowości. Autor uważa, że gatunki folkloru stają w pewnym sensie narzędziem ideologicznego wpływu na ludność, poprzez nieodłączne ponowienie schematów interpretacji wydarzeń, które stały częścią ludzkiej kultury.
One-Winged Momentum-Biased Solar Sail: A New Methodology for Propellantless Attitude Control
Authors: Takao Yuki
Published: February 2023

This paper proposes a new methodology for solar-sail attitude control that uses only momentum wheels. Different from conventional solar sails packaged in a central hub, the sailcraft is deployed in the direction of one side of the storage. In this single-wing configuration, the offset between the center of mass (c.m.) and center of pressure (c.p.) is large and lies in the sail plane. When specular reflection is dominant, solar-radiation-pressure (SRP) force vector points in the out-of-plane direction, thus causing an in-plane SRP torque orthogonal to the c.m./c.p. offset vector. Therefore, by placing a bias momentum in the c.m./c.p. direction, the sailcraft keeps rotating in the same plane while maintaining its orientation relative to the sun. Analysis reveals that the attitude motion of the one-winged momentum-biased solar sail is basically unstable, but the system can be stabilized in a neutral manner through minor control of the bias momentum. Furthermore, adding another control moment in the out-of-plane direction enables asymptotic stability. Control in the remaining in-plane direction makes it possible to avoid wheel saturation. Numerical simulations demonstrate that both attitude maintenance and maneuver can be performed and that the controller is robust to parameter errors.
Refining Kutta’s Flow over a Flat Plate: Necessary Conditions for Lift
Authors: Taha Haithem E. , Gonzalez Cody
Published: February 2023

In this paper, we present a variational theory of lift that, unlike Kutta’s theory, is derived from first principles in mechanics: Hertz’s principle of least curvature. In this theory, the unique value of circulation is determined by minimizing the Appellian of the flowfield. Interestingly, it recovers the Kutta condition in the special case of an airfoil with a sharp trailing edge. In this paper, we apply such a theory to the classical problem of the flow over a flat plate. The resulting ideal flow does not match Kutta’s solution in this case; it results in a nonlifting solution for any uncambered, fore-aft symmetric shape, confirming experimental findings in superfluids. This result provides necessary conditions for lift generation in an ideal fluid. For a real fluid over a flat plate with a sharp leading edge, viscosity plays an important role, leading to a flow separation at the leading edge, even at small angles of attack. This separation bubble creates asymmetry in the outer inviscid flowfield (outside the bubble), which enables lift. This problem is discussed in the light of the developed variational theory of lift and some historical details about the development of Kutta’s theory.
Capacitação interprofissional sobre gestão da demanda, acolhimento e classificação de risco na Atenção Primária à Saúde
Authors: Estevão Túlio de Almeida , Sousa Milena Nunes Alves de
Published: February 2023

Objetivo: Realizar capacitação interprofissional sobre gestão da demanda, acolhimento e classificação de risco na Atenção Primária à Saúde, em um município do sertão da Paraíba, a fim de propiciar melhorias na logística do atendimento. Relato de experiência: A partir de uma atividade prática da residência de Medicina de Família e Comunidade foi possível identificar fragilidades do serviço de saúde, sendo utilizada a metodologia do Arco de Maguerez, composto por cinco etapas. Na primeira etapa, foram observados aspectos na dinâmica dos atendimentos, que resultavam em um grande fluxo de pacientes. No levantamento dos pontos chaves, foram identificados fatores relacionados ao problema e após a teorização elencaram-se as intervenções, mediante oficinas presenciais abordando os temas de gestão da demanda, acolhimento com classificação de risco e demanda programada, bem como a aplicação na realidade, que foi realizada através de capacitação com a equipe multidisciplinar. Considerações finais: As intervenções levaram a melhoria da dinâmica dos serviços devido ao aperfeiçoamento na gestão da demanda por meio da implementação do acolhimento com classificação de risco.
Formulation and the Study of Finished Products used for Anginal Disease
Authors: Singh Charanjeet . , . Yashwant . , Gupta Anil K.
Published: February 2023

Congestive heart failure is a type of disease which is mainly observed due to the improper supply of blood to the heart. In this disease patient feels severe pain in the chest and may cause serious illness. Sudden treatment is needed in this disease to prevent any fatality. Nitroglycerin is the choice of drug for this disease. This study prepares a dosage form that can deliver the drug at a fast rate like a sublingual tablet of nitroglycerin. Sublingual dosage form was manufactured by direct compression method. For the formulation, multiple excipients like super disintegrants, sweeteners and lubricants were used. The finished dosage form was evaluated for different quality parameters. Optimum formulation was compared with the marketed product and kept on the accelerated stability study. Results were observed as satisfactory and comparable with the marketed product.
Stable Amorphous Solid Dispersion of Eplerenone Prepared with Water Soluble Polymer by Spray Drying Technique
Authors: Bagul Kunal . , Mundada Atishkumar .
Published: February 2023

Class II in the Biopharmaceutical Classification System, eplerenone (EPL) is a selective aldosterone antagonist. Due to its poor solubility, EPL has limited bioavailability. Here, an innovative spray-drying method was used to transform a water soluble polymer into an amorphous dispersion of the EPL. Different polymer SOL/EPL ratios were tested to determine EPL’s solubility and dissolution enhancement properties. In order to learn more about the physical and chemical properties of this novel amorphous solid dispersion (ASD), methods like powder X-ray diffraction spectroscopy (PXRD), differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR), particle size distribution (PSD) using a Malvern instrument, and scanning electron microscopy (SEM) were used. There was no chemical interaction between the binary mixture of EPL and SOL which was confirmed from the FTIR spectra obtained. The enhancement in the solubility and dissolution of EPL and binary mixture prepared were due to the amorphous conversion of EPL in the SOL polymer (amorphous solid dispersion), which was confirmed from DSC thermogram, PXRD spectra obtained and was also confirmed from the solubility study, in-vitro dissolution study. Finally, ex-vivo intestinal absorption study performed on the goat intestine using amorphous solid dispersion and pure EPL, also improved intestinal absorption of EPL through amorphous solid dispersion prepared.
Stability Indicating Quality by Design-based Development and Validation of Bilastine and Montelukast by Ultra Performance Liquid Chromatography Method
Authors: Bandi Swarupa . , Adikay Sreedevi .
Published: February 2023

Background: The current work, which was conducted under the quality by design (QbD) paradigm, aims to establish the optimization of ultra-performance liquid chromatography (UPLC) using the design of experiments and response surface theory, such as central composite design (CCD), in order to achieve a good separation and resolution. Methods: The mobile phase was composed of methanol (20:80% v/v) and 0.1% tri fluro amine (TFA) buffer, and chromatographic separation was performed on column phenomenex C18 (50 mm x 4.6 mm x 2.5 m) at a flow rate of 0.4 mL/ min. Montelukast (MON) and bilastine (BIL) were both detected at 260 nm. The suggested method was approved in accordance with International Council for Harmonization (ICH) recommendations. Results: The created technique successfully separates both BIL and MON with a chromatographic resolution of 6.4. The technique was linear for BIL and MON concentrations of 0.5–3.0 μg/mL and 0.25–1.5, respectively, and recovery rates ranged from 99–100%. The drug compounds had distinct degradation products that were identified in stress patterns. Conclusion: For the quantification of BIL and MON in the combination tablet, a precise, simple, reliable, and accurate UPLC method was designed. According to the method validation, it was possible to successfully separate two medicines from their degradants utilizing aQbD techniques.
Development and Validation of an Analytical Method for the Simultaneous Estimation of Azadirachtin and Camphor in a New Herbal Formulation
Authors: Khristi Avani . , Patel Swati . , Wagh Yukti .
Published: February 2023

Background: High-performance liquid chromatography (HPLC) is an analytical tool for determining the quality of a drug product. Separating, identifying, and quantifying the various drugs should be able to HPLC methods. To quantify azadirachtin and camphor, a novel HPLC technique was created that is sensitive and selective.
Objective: The analysis of azadirachtin and camphor has been designed and verified using a simple, efficient, selective, and precise HPLC technique.
Material and Method: With the help of an HPLC C18 column (4.6 x 250 mm, 5 m), a mobile phase made up of buffer (pH adjusted to 3.0 with orthophosphoric acid) and acetonitrile in the ratio 15:85, flow rate of 1.0 mL/min, and column temperature kept at 35°C, good chromatographic separation was achieved in the current study. The resulting effluents were seen at 294 nm using a UV-visible detector.
Result and Discussion: Sharp peaks for azadirachtin and camphor were found at retention times of 3.5 and 4.8 minutes, respectively, during the detection process at 294 nm. Over the concentration ranges of 0.1–0.9 g/mL for azadirachtin and 20–180 g/mL
for camphor, the calibration curve was linear. According to International Council on Harmonisation (ICH) guidelines, the method was verified for accuracy, precision, repeatability, specificity, robustness, and detection and quantification limits.
Conclusion: The proposed method has specificity, accuracy, and sensitivity, with an excellent linear.
A Novel Stability Indicating Reversed Phase Ultra Performance Liquid Chromatography Method for Estimation of Asciminib its Bulk and Tablet Formulation
Authors: Priya Dandamudi S. , Gubbiyappa Shivakumar . , Rangapuram Vasanthi .
Published: February 2023

The key objective of the proposed study was to creat and validate an economical, perceptive, specific, reliable and simple reversed phase ultra-performance liquid chromatography (RP-UPLC) method with better response was anticipated for the investigation of asciminib bulk powder and its tablet form. UPLC system (WATERS, Model-2695) connected with PDA (Model-2996) detector was opted to made the present method. To separate asciminib proficiently, method conditions such as C18 column (50 x 4.6 mm, 1.7 m), mobile system of trifluoro aceticacid (TFA) in water (0.1%) and acetonitrile in 75:25 v/v, 0.3 mL/min flow rate and 260 nm wavelength were used as optimized chromatographic conditions. The anticipated method was validated by the ICH specifications. The retention time of asciminib was noticed at 0.925 minute with good efficiency, respectively. Linearity was noticed for concentrations ranging fom 5 to 30 μg/mL of asciminib with R2 value of 0.999. The %RSD of both system and method precision was assessed in the range of 0.49 to 0.86. The percentage recovery of asciminib was in the range of 100.06–100.6%. The logarithm of the odds (LoD) and limit of quantitation (LoQ) of asciminib determined to be 0.23 and 0.69 μg/mL correspondingly. The results confirmed that the projected technique was economical, simple, responsive and precise. Exploration of asciminib under various FD environments confirms the stability representing the nature of the stated method. The proposed UPLC method is extremely valuable in the separation and estimation of asciminib.
Evaluation of occlusion parameters using T-scan III in patients receiving fixed orthodontic treatment
Authors: Sadry Sanaz , Giray Bilgin
Published: February 2023

Objectives:

The aim of this study is to examine the relationship between occlusal factors and temporomandibular joint diseases (TMD).

Material and Methods:

In our study, 43 individuals who had fixed orthodontic treatment and 20 individuals who did not need treatment at Istanbul Aydin University Faculty of Dentistry Department of Orthodontics were included in the study. Evaluations were made at the beginning of treatment (T0) and at 6 months (T1). T-Scan® computerized Occlusion Analyzer was used to evaluate the number of contact points, occlusal force parameters during centric occlusion and lateral movements, and occlusion and disclusion times. Differences between groups were evaluated with Mann–Whitney or independent t-test, and within-group differences were evaluated with Wilcoxon sign test or paired t-test, depending on whether the data showed normal distribution or not.

Results:

There was no statistically significant distinction between the gender-based parameters and right and left joint of Joint Vibration Analysis record in all three groups (P > 0.05). At the beginning of orthodontic treatment, there was no statistical difference in the variables within the group and between the groups. As a result of the comparison between the beginning of treatment (T0) and the 6th month (T1), no significant difference was found between the parameters of the anterior/posterior occlusal force distribution of the right-left quadrant and the force distribution of the working and non-working sides in lateral movements, and the occlusion and disclusion time parameters. Maximum intercuspal position left/right (MxlntlTSCANT1) was found to be statistically significant at 6 months in individuals who received fixed orthodontic treatment with extraction compared to the none xtraction treatment group (P < 0.05).

Conclusion:

According to our research, T-scan is one of the best devices for the early detection of TMD, especially for people undergoing orthodontic treatment. T-scan offers fast, non-invasive, and repeatable occlusion recording.
Evaluating the quality of life among patients undergoing orthognathic surgery using a customized questionnaire: A prospective study
Authors: Bhandari Sujit Kumar , Issar Yuvraj , Rana Ravinder Pal Singh , Datana Sanjeev
Published: February 2023

Objectives:

A questionnaire, specific to the clinical condition treated is important. The aim of this study was to evaluate the Quality of life (QOL) amongst patients undergoing orthognathic surgery using a customized questionnaire encompassing, patients’ perception of facial form and also patient perception of overall quality of care provided during the entire treatment.

Material and Methods:

This prospective, qualitative, observational study was carried out on 21 patients, who underwent Ortho-surgical management between Jan 2019 and Mar 2020. The Orthognathic QOL questionnaire was customized, Phase I, immediately prior; and Phase II, 6 months after surgery. Appropriate analysis was done to compare Phase I and Phase II, with the level of significance set to P < 0.05.

Results:

“Aesthetics” was the most frequent reported reason for seeking treatment. The mean pre-/post-treatment difference for oral function was statistically significant. Majority (87%) of patients reported surgical outcomes met their expectations. Results, post-surgery; good hospital care (33.3%), supportive doctors (28.57%) and regular follow up (9.52%).

Conclusion:

“Patients’ perspective” of treatment, is often neglected, the immense importance of which has been duly reflected in our study. We recommend the use of our questionnaire in a similar, broad based multicentric study with a larger patient base, will aid in improving overall outcome of ortho-surgical interventions.
Synthesis, molecular docking and in vitro anti-bacterial activity of formazan derivatives
Authors: Aggarwal Natasha Naval , Gatphoh Banylla Felicity Dkhar , Madan Kumar S. , Ashok Kumar K.V. , Revanasiddappa B.C.
Published: February 2023

A new series of Formazan derivatives (F1-10) was synthesized by the reaction of equimolar concentrations of Schiff bases (SB1-10) and Diazonium salts. FT-IR, 1H-NMR and Mass spectral data established the structures of the newly synthesized compounds. In-silico analysis was carried out using Schrodinger suite device and docked to the binding site of Human Poly(ADP-ribose) Polymerase (PDB ID: 3V2B). The highest affinity is demonstrated by compound F2 having a binding energy of -3.158 kcal/mol. All the new compounds were screened for antibacterial potency. Some of the synthesized compounds F4, F9 displayed good antibacterial activity against all the bacterial organisms when compared to the standard.
Micelle Sensitized Physicochemical Studies on Erbium(III) Complexes with Hypoglycemic Sulfonylurea Drugs
Authors: Ghasia S. , Regar R. , Bhandari H.S.
Published: February 2023

Hypoglycemic sulfonylurea derivatives ligands viz. glimepiride, glibenclamide, gliclazide and glipizide show interaction with lanthanide metal Er (III) in non-micellar and micellar medium. Anionic, cationic and non-ionic surfactant micellar media show great variation in oscillator strength of Er (III) with hypoglycemic sulfonylurea drugs as reflected in UVVisible absorption spectra. Interpretation of UVVisible absorption spectra produced that 4G11/2 ← 4I15/2 and 2H11/2 ← 4I15/2 electronic transition bands show different behavior on account of oscillator strength (P) compared to other electronic f-f transitions, depicted as hypersensitive peaks which are characterized as ratio of Pmicellar / PDMF. Exploitation of different parameters viz: oscillator strength (P), Judd-Ofelt parameter Tλ, nephelauxetic effect 𝛽 and bonding parameter b1/2 from absorption spectra supports the covalency characters in metal ligand Er (III)-drugs doped systems to a greater extent. Thermodynamic exploits of hypersensitive transition correlate the spectroscopic data via Work function A, Thermodynamic efficiency of transition TET and Partition function Q. Thermodynamic parameters notify the microscopic behaviour of Er (III)- sulfonylurea drugs.
Effects of arsenic-induced toxicosis (Arsenicosis) on human health and its prevention
Authors: Mairaj Samya , Nagar Richa Dave , Rehman F. , Jindal Tanu
Published: February 2023

Owing to widespread groundwater pollution, arsenic is one of the most extreme worldwide ecological toxicants and induces cytotoxic activity and other chronic diseases for millions of people and also animals. Because of geologic and anthropogenic activities, arsenic pollution is widely spread. Long-term toxicity caused by arsenic can lead to the development of arsenicosis related to skin lesions, hepatomegaly, splenomegaly, cognitive dysfunction, cardiovascular and peripheral vascular disease, hypertension, diabetes mellitus, hepatic fibrosis and hematological, gastrointestinal, immunological, endocrine and multicancer neurological disorders. Till date no effective treatment or medicine is available in global market to prevent arsenic induced toxicosis. Only use of safe water and well nourished foods can help to prevent further exposure. Recently, chelation therapy is recognized as a good remedial action to reduce and to eliminate the acute arsenic toxicity.
Syntheses, Crystal Structure and Conducting Property of New 4-N,N-dimethyl benzyl-N-benzyl dithiocarbamato Cu(II) Complex
Authors: Kumar Vinod , Kumar Anil , Pandey Neelesh Kumar , . Vidyottma , Prakash Ravi
Published: February 2023

A new homoleptic copper (II) dithiocarbamate complex having molecular formula [Cu(C17 H19N2S2)2], has been synthesized and characterized by elemental analysis and spectroscopy (IR and UV–Vis). Single crystal X-ray studies confirm that the complex crystallises in monoclinic with space group P121/c1 and holding dimeric structure by weak Cu...S and H...H intractions. The existence of attractive intermolecular C−H⋯H−C interaction is a notable feature in the crystal packing of this complex. The electrical conductivity measurement between temperatures range of 303–393 K reflects that complex exhibits weak semiconducting behavior.
Infections Related to Post-Surgery Pediatric Patients of Congenital Cardiopathy in a High Specialty Medical Unit
Authors:   Intensive Care Pediatric Unit, “Dr. Gaudencio González de la Garza, Unidad Medica de Alta Especialidad, Centro Medico Nacional La Raza” Hospital, “Instituto Mexicano del Seguro Social” Institute, Mexico, USA, Rosalinda Jimenez-Aguilar , MP Lozada-Mata ,   Resident, ClinicNeurology, “Unidad Medica de Alta Especialidad, Hospital de Especialidades Dr Antonio Fraga Mouret, Centro Medico Nacional La Raza”, “Instituto Mexicano del Seguro Social” Institute, Mexico, USA, W Tenorio-Gutierrez ,   Intensive Care Pediatric Unit, “Dr. Gaudencio González de la Garza, Unidad Medica de Alta Especialidad, Centro Medico Nacional La Raza” Hospital, “Instituto Mexicano del Seguro Social” Institute, Mexico, USA, AYG Yañez ,   Biomedical Resident.Universidad Tecnologica del Estado de Mexico, Mexico, USA, E Dueñas ,   Reference and Diagnostic National Institute, National Health Department, Mexico, USA
Published: February 2023

Background: Congenital heart diseases are frequent malformations, in Mexico is second death cause among children under one year. The cardiac disease is the top cardiothoracic surgery, being the nosocomial infection important to consider. Materials and Methods: Observational and descriptive study of patients who underwent cardiac surgery. Results: The study included 165 patients; 12 developed nosocomial infection. Children under one year old has higher risk of infection (63.6%).The common microorganism isolated were Pseudomonas aeruginosa and Klebsiella pneumoniae. Conclusions: The development of nosocomial infections was minimal. Surgeries are more frequent in children under one year related to frequency of infectious complications.
Risk Factors for Vocal Cord Paralysis and Hoarseness Following Endotracheal Intubation
Authors:   Department of Cardiovascular Surgery, St. Luke’s International Hospital, Japan, Y Nakamura , N Fujita ,   Department of Anesthesiology, St. Luke’s International Hospital, Japan, A Yamaguchi ,   Department of Anesthesiology, St. Luke’s International Hospital, Japan, O Takahashi ,   Department of General Internal Medicine, St. Luke’s International Hospital and Professor and Vice Dean of Graduate School of Public health, St. Luke’s International University, Japan
Published: February 2023

Background: Hoarseness following endotracheal intubationis a complication that may persist due to recurrent laryngeal nerve palsy, which can impair the quality of life. Here, we evaluated the risk factors for recurrent laryngeal nerve palsy following endotracheal intubation. Methods: We conducted a single-center retrospective cohort study of all surgical patients who underwent general anesthesia and intubation at St Luke’s International Hospital from January 1, 2011, to July 31, 2020. To identify risk factors for recurrent laryngeal nerve palsy following endotracheal intubation, Fisher’s exact test and t-test were used for univariate analysis, and logistic regression analysis was used for multivariate analysis. Results: Of the 46,617 eligible cases, 14 (0.03%) developed vocal cord paralysis. Multivariate analysis revealed a significant association between postoperative hoarseness (OR=42.4, 95%CI=12.8-141.0, p<0.001) and the development of vocal cord paralysis. Sub-analysis with hoarseness as the secondary outcome revealed that hypertension, cuff pressure measurements, and anesthesia time were significantly associated with the development of postoperative hoarseness. Conclusion: Understanding the risk factors for recurrent laryngeal nerve palsy in surgical patients may help to identify those at high-risk of post-intubation hoarseness and vocal cord paralysis preoperatively and intraoperatively, and allow for more targeted management during intubation.
Hyperglycemia as a Sequel to Covid-19
Authors:   Department of Education, Mexican Institute of Social Security UMF32, University of Monterrey, Mexico, HA Flores , GM Orozco ,   Department of Education, Mexican Institute of Social Security UMF32, University of Monterrey, Mexico, DL García ,   Department of Education, Mexican Institute of Social Security UMF32, University of Monterrey, Mexico, ME López ,   Department of Education, Mexican Institute of Social Security UMF32, University of Monterrey, Mexico, BL Escobedo ,   Department of Education, Mexican Institute of Social Security UMF32, University of Monterrey, Mexico, G Ramírez ,   Department of Education, Mexican Institute of Social Security UMF32, University of Monterrey, Mexico
Published: February 2023

Background: SARS-CoV-2 has generated a severe economic, social and health crisis throughout the world. Multiple experimental and clinical studies have suggested that in addition to generating a pulmonary clinical presentation, it can also cause lesions in different systems. The present study seeks to associate that SARS-CoV-2 infection can generate a hyperglycemicstate in patients without a previous diagnosis of Diabetes Mellitus, as well as to find the prevalence of this complication in specific groups of the population. Overall Objective: To determine the prevalence of hyperglycemia in the subjects who studied COVID-19 of the Family Medicine unit No 32. Material and Methods: An observational, descriptive, cross-sectional and retrospective study was developed with a non-probabilistic sampling of consecutive cases in the population of patients with COVID-19 of the Family Medicine Unit No. 32 of the Mexican Institute of Social Security with an age range of 18 - 65 years. Obtaining a sample of 152 participants who met the inclusion criteria. Results: A prevalence of 30.26% was found in the participants who presented post-COVID hyperglycemic figures. Conclusion: In the present study we can conclude that there was an alteration in post-COVID serum glucose levels without the use of steroids, which is why future follow-up is suggested for patients who suffered from COVID-19 to monitor the possible onset of pre-diabetes or diabetes.
Color Vision Pathway Follows the Expansion Repeats in SCA7
Authors:   National Researches Council, Institute of Molecular Bioimaging and Physiology, Germaneto (Catanzaro), Italy, Piro Anna , Rosa Daniel La ,   Operative Neuroradiology Unit, Magna Graecia University, Catanzaro, Italy, Mechelli Alessandro ,   Institute of Neurology, Magna Graecia University, Catanzaro, Italy, Quattrone Andrea ,   Institute of Neurology, Magna Graecia University, Catanzaro, Italy, Quattrone Aldo ,   National Researches Council, Institute of Molecular Bioimaging and Physiology, Germaneto (Catanzaro), Italy
Published: February 2023

Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disorder caused by gene ataxin7 mutation with a polymorphic CAG repeat tract that falls in first axon. The gene which encodes ataxin7 normally contains a ten CAG repeat tract starting a codon 30, in affected patients the CAG repeat tract expands from 37 to 250 triplets, decreasing the transcription of an antisense non-coding RNA. Clinically SCA7 is characterized by progressive cerebellar ataxia, slow saccadic eye movements and progressive blindness. SCA7 neurotoxicity can be showed by the cone-rod dystrophy which follows in the generations the CAG repeats expansions in the affected patients. As retinal disease progresses in SCA7, the photoreceptors cells do become involved, and then loss of central visual acuity proceeds to complete blindness. The presence in the long run of the altered cone function, allows SCA7 to be classified as a cone dystrophy type of retinal degeneration [1]. Considering the X-linked inheritance of color vision deficiency, fixed sampling of only males, that compensation’s phenomenon in the heterozygous females [2], which can hid a real acquired color vision deficiency. The acquired color vision deficiency is real in the males where the anomaly has not hidden, and due to this reason we suggest sampling only male patients when color vision has studied both in neurological and metabolic diseases [3].
Manifestation of Corneal Wound Gap during Cataract Surgery: A Case Report
Authors:   Department of Ophthalmology, Jinan Mingshui Eye Hospital, Zhangqiu District, Jinan City, People’s Republic of China, X Wang , Y Li ,   Department of Ophthalmology, Jinan Mingshui Eye Hospital, Zhangqiu District, Jinan City, People’s Republic of China, C Zhang ,   Department of Ophthalmology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Lixia District, Jinan City, People’s Republic of China, G Dang ,   Department of Ophthalmology, Jinan Mingshui Eye Hospital, Zhangqiu District, Jinan City, People’s Republic of China
Published: February 2023

Significance: Intraoperative AS-OCT showed great advantages in the treatment of the patient with traumatic cataract and corneal perforation, and could be used to real-time monitor the changes of corneal wound and the IOL position. Purpose: To report the change of corneal wound in a patient with traumatic cataract and corneal perforation during the anterior segment-OCT-assisted (ASOCT- assisted) cataract surgery. Case Presentation: A 48-year-old male patient, whose right eye was injured by a steel wire two months ago, presented with traumatic cataract and corneal perforation. When he was referred to our hospital, the corneal epithelium and part of anterior stroma at the laceration had healed. Therefore, the corneal laceration was not sutured, and AS-OCT was conducted to monitor the corneal laceration and assess the IOL position during cataract surgery. The laceration maintained closed, and no liquid leakage through corneal laceration was found throughout the surgical operation. IOL was placed into the capsular bag, and the visual acuity of the affected eye recovered to 3/10 postoperatively. Conclusions: Intraoperative AS-OCT could be used to real-time monitor the changes of corneal wound and the IOL position, and showed a significant advantage in the treatment of the eye with traumatic cataract and corneal perforation
Lipid molecular species composition of two freshwater microalgae Nitzschia palea and Scenedesmus costatus by HPLC-ESI-MS/MS
Authors: Mazzella Nicolas , Fadhlaoui Mariem , Moreira Aurélie , Morin Soizic
Published: February 2023

This work reports the polar lipid profiles of two freshwater algae: the diatom Nitzschia palea, widespread alga that typically inhabits freshwater ponds and rivers, and the Scenedesmus costatus, a common green alga. HILIC-ESI-MS/MS analysis was used to determine and quantify the major phospholipids and glycolipids, and their relative molecular species, extracted from the two microalgal cultures. Glycolipids were eluted first, followed by phospholipids partially co-eluting with the sulfoglycolipids. We also studied the fragmentation pattern in the negative ionization mode for galactolipids. The most intense daughter ion corresponded to the fatty acyl chain located at the sn-2 position, which allowed us to determine the stereospecific distribution of the following fatty acids on the glycerol backbone. For green algae, 18:3 fatty acid was frequently occurring in both phospholipids and galactolipids. We also found 16:4 in some molecular species of mono- and digalactosyldiacylglycerol (MGDG and DGDG). The most abundant and characteristic molecular species of MGDG in green algae exhibited the combination (18:3/16:4), whereas DGDG was more saturated than MGDG and contained mainly 18:1, 18:2, or 18:3 at sn-1 and shorter fragments 16:0, 16:1, 16:2, and 16:3 at sn-2. It is also remarkable that in the diatom, the phospholipids contained mainly molecular species with saturated or monounsaturated fatty acids such as 16:0, 16:1 and 18:1. In contrast, MGDG and DGDG contained a higher proportion of polyunsaturated fatty acids, such as the unique and abundant MGDG (20:5/20:2).
Pericyclic or Pseudopericyclic? Deep Mechanism Insight into The Mi-gration Selectivity of Cb-Substituted-4aH-Carbazoles: Competition between Orbital Interaction and Electrostatic Interaction
Authors: Zhang Jingyang , Zhao Yaqiu , Zu Liansuo
Published: February 2023

The migration selectivity of Cb-substituted-4aH-carbazoles has been studied by DFT methods. For n-Bu and Ph substituted sub-strates, C4 migration and Ca-C1 migration are all pericyclic. C4 migration is favorable for more aromatic transition states. For halo-gen substituted substrates, C4 migration locates in the junction zone of pericyclic reactions and pseudopericyclic reactions while Ca-C1 migration is pseudopericyclic. Ca-C1 migration is favorable due to more positive NPA charges and LUMO distributions on Ca than C4. The acid catalysts with large steric hindrance can adjust the reaction selectivity through to some extent.
A solid-phase compatible silane-based cleavable linker enables custom isobaric quantitative chemoproteomics
Authors: Burton Nikolas , Polasky Daniel , Shikwanna Flowreen , Ofori Samuel , Yan Tianyang , Geiszler Daniel , da Veiga Leprevost Felipe , Nesvizhskii Alexey , Backus Keriann
Published: February 2023

The human proteome harbors tens of thousands of ligandable or potentially druggable cysteine residues. Consequently, pinpointing the optimal covalent molecule for each cysteine residue is a key challenge for chemical probe and drug discovery campaigns. While chemoproteomic methods have enabled proteome-wide screens of electrophilic molecules, achieving comprehensive proteome-wide structure activity relationship (SAR) maps requires technical innovation in two key areas: (1) streamlined sample preparation workflows and (2) increased sample throughput via multiplexing. Recent inroads in the latter challenge have been made through the incorporation of isobaric tandem mass tags (TMT) into chemoproteomic workflows; the high cost and late-stage isobaric labeling collectively have, however, limited adoption of such MS2/MS3-based quantitation strategies. Here we report the silane-based Cleavable Linkers for Isotopically-labeled Proteomics (sCLIP) method, which harnesses custom isotopically labeled chemoproteomic capture reagents to simplify sample preparation and achieve low cost 6-plex isobaric multiplexing. The sCLIP method is enabled by a high yielding and scalable route to dialkoxydiphenylsilane fluorenylmethyloxycarbonyl (DADPS-Fmoc) protected amino acid building blocks, which enable facile synthesis of customizable, isotopically labeled, and chemically cleavable biotin capture reagents. Benchmarking of a panel of fully functionalized sCLIP capture reagents revealed performance comparable to established platforms. Using the diagnostic ion mining of the FragPipe computational pipeline, we identified a characteristic fragment ion with suitable intensity and specificity for tandem mass spectrometry (MS2)-based quantification. By harnessing this unprecedented gas phase chemistry, we established a cost-effective high performance 6-plex isobaric reagent set in which the mass balancer and reporter are encoded in the cysteine-capping and biotin capture reagents, respectively. Application of the sCLIP reagents to chemoproteomic analysis of electrophilic molecules uncovered 4805 total ligandable cysteines, including established and unprecedented cysteine-ligand pairs.