bluuebunny/crossref_metadata_2025 huggingface dataset:
The Synergistic Effect of Warm Salt Footbath and Foot-Ankle Exercises in Individuals with Type 2 Diabetes Mellitus: A Study Protocol for Multicenter Randomized Controlled Trial
Authors: Sirait Healthy Seventina , Said Faridah Mohd , Mohamad Nur Afiqah
Published: December 2024

Individuals with type 2 diabetes mellitus (T2DM) experience issues with their sleep quality and elevated level of the neutrophil-lymphocyte ratio (NLR). Warm salt footbaths and foot-ankle exercises play a significant role in addressing inflammation and improving sleep quality. Nevertheless, no studies have examined the synergistic effects of warm salt footbaths and foot-ankle exercises. This study aims to investigate the synergistic effects of warm footbath water and foot-ankle exercises on sleep quality and NLR. A randomized controlled trial with a total of 108 individuals with T2DM randomly assigned to one four groups: a warm salt footbath, a foot-ankle exercises, a combination of both interventions, or a control group. The interventions administered over a period of   4 weeks (three times per week). Evaluations were performed by blinded evaluators at baseline, as well as after 2 and 4 weeks of interventions. Chi-squared test, one-way analysis of variance, and generalized estimating equations were employed for data analysis. The results of this trial were expected to elucidate the synergistic effects of warm salt water footbath and foot-ankle exercises on sleep quality and NLR. Furthermore, the combination of warm salt water footbaths and foot-ankle exercises is more effective either intervention alone or conventional treatment.
Family Needs of Patients Admitted in The Intensive Care Unit: A Meta-Synthesis
Authors: Ismail Suhartini , Lahati Nurul Safira , Morales Jeremy Godofredo
Published: December 2024

The life threats for patients admitted in the Intensive Care Unit (ICU) is higher compared to other care units. The magnitude of the life threats in the ICU not only causes anxiety for patients but also for other families. The family has crucial roles in supporting the patient's recovery, so the holistic needs of the patient's family also require to be considered. This meta-synthesis aimed to synthesize findings from qualitative studies that explored and described the needs of families while accompanying patients in the ICU. A systematic literature search from online databases was used to conduct a qualitative meta-synthesis, which was then evaluated using Critical Appraisal Skill Programme (CASP) checklist for Qualitative Study. Literature that fit the requirements was further analyzed. Three main themes that were fundamental for families were revealed including the need for information, the need for family involvement in patient care, and the need for visiting time for the family. Understanding the family as a unit brings benefits to the patient. It is essential to adapt professional practice strategies that involve families in the daily care of critical patients. Further research is required on how to carry out interventions that translate this knowledge into nursing care practices and actions.
Health Literacy and Medication Adherence among Patients with Hypertension
Authors: Lenggogeni Devia Putri , Yeni Fitra , Malini Hema , Anyati Reffy
Published: December 2024

Hypertension requires patients to adhere to a medication regimen that needs to be adhered to for life to control blood pressure and prevent complications. A related factor to medication adherence is patients' health literacy, which influences their ability to maintain hypertension prescription regimens. This factor is critical in managing chronic diseases, such as hypertension, to achieve optimal health.  This study aims to investigate the relationship between health literacy and medication adherence in patients with hypertension. The study was conducted at public health care centers in West Sumatra. This study used a quantitative approach with a cross-sectional design. The researchers used a non-probability sampling technique, namely purposive sampling, for a total sample of 175 respondents. Data were collected using the Morisky Medication Adherence (MMAS-8) and Health Literacy Survey Europe-16 (HLS-EU-Q16) questionnaires. Data were processed using computerization with chi-square test. The results showed that 41.7% of patients with hypertension have sufficient health literacy, and 46.9% have low levels of medication adherence. In addition, 52.3% with inadequate health literacy had low levels of medication adherence. The statistical test results obtained a p-value = 0.001 (p < 0.005), indicating a relationship between health literacy and medication adherence. It is essential to improve hypertension treatment adherence by improving the health literacy of patients with hypertension.
The Determinant Mother Feeding on Children under Five Stunting Health Center in Rural Area
Authors: Ummah Arief Khoerul
Published: December 2024

Stunting is a significant nutritional issue affecting children that has been the world's concern in recent years, especially in developing countries. The study aims to identify the determinant factors affecting mothers’ feeding practices for children experiencing stunting. The research used an observational and correlation design involving 258 respondents from three health centers. Data were collected through a questionnaire conducted between December 2022 and January 2023. The data analyzed utilized chi-square tests and logistic regression. The variables that dominantly contribute to the practice of meal provision included economic factors for children under five with stunting (P = 0.001, OR = 4.276), compared to other variables such as knowledge (P = 0.004, OR = 2.632), attitude (P = 0.001, OR = 3.237), hygiene (P = 0.013, OR = 3.552), and cultural factors (P = 0.001, OR = 3.216). Economic factors emerged as the primary determinants influencing meal provision practices for stunted toddlers. Economic factors were also dominantly associated with maternal feeding practices for stunted children under five in rural areas
The Cytotoxic Evaluation of Steroids Isolated from Dysoxylum alliaceum (Blume) Blume ex A.Juss.
Authors: Riyadi Sandra Amalia , Naini Al Arofatus , Mayanti Tri , Lesmana Ronny , Azmi Mohamad Nurul , Supratman Unang
Published: December 2024

Dysoxylum alliaceum belongs to the Dysoxylum genus (Meliaceae) and there are few reports concerning the phytochemical components of this plant. To examine the chemical constituents of Dysoxylum alliaceum stem bark, a phytochemical study has been conducted and identified five known steroids, 3β,16β-dihydroxy-24(S)-methyl cholestenol (1), ergosta-5,22-dien-3β-ol (2), ergosta-7,24(28)-dien-3β-ol (3), 22(E)-ergosta-6,22-dien-3β,5α,8α-triol (4), and 20α-dihydroprogesterone (5) from its ethanolic extract. Spectroscopic data such as FT-IR, HR-ESI-MS, 1D, and 2D NMR as well as comparison with previously published spectral data were used to identify the chemical structures of compounds 1–5.  Furthermore, these steroids 1-5 were assessed in vitro regarding their cytotoxic effect against A549 lung cancer cell lines and revealed weak to inactive with IC50 values ranging from 68.52 to >150 µM.
Keywords: A549 cell lines, cytotoxic evaluation, Dysoxylum alliaceum (blume) blume ex a.juss, meliaceae, steroid
Authors: Firdaus Fazri , Tabrani Rizqi A’mal Hibatullah , Saefullah Asep , Antarnusa Ganesha
Published: December 2024

Telah dilakukan penelitian untuk analisis gugus fungsi pada sampel Fe3O4 yang disintesis hijau / Green Synthesis (GS) menggunakan Moringa Oleifera (MO) dan nanopartikel oksida besi hitam (Fe3O4) menggunakan FTIR-Spectroscopy. Analisis gugus fungsi sampel dilakukan Untuk memastikan ada tidaknya perbedaan pada terbentuknya MNPs dari penggunaan MO, ikatan molekul diamati menggunakan spektra FTIR. Adanya puncak serapan nanopartikel magnetit menunjukkan dua pita vibrasi pada kisaran bilangan gelombang 596-642 cm-1, yang sesuai dengan vibrasi peregangan ikatan M-O (logam-oksida). Serapan di sekitar 578 cm-1 berhubungan dengan vibrasi peregangan pada situs tetrahedral logam (Fetetra-O). Pembentukan GS-Fe3O4 sangat dikonfirmasi dengan adanya karakteristik yang serupa dengan Fe3O4 konvensional pada kisaran bilangan gelombang 1391, 1633 dan 2318 cm-1, yang mewakili vibrasi peregangan ikatan kimia C=O, N-H, C=O, dan puncak serapan lain yaitu pada bilangan gelombang 3167 cm-1 yang berkaitan dengan vibrasi gugus O-H (hidroksil).
Rancang bangun smart door double lock menggunakan sensor RFID dan piezoelektrik dengan home security detector berbasis IoT
Authors: Cahyani Ningrum Ayu , Hartono Hartono , Pratiwi Umi
Published: December 2024

Seiring berkembangnya ilmu pengetahuan dan teknologi, kunci konvensional dinilai semakin tidak efisien. Selain rentan terhadap pembobolan, kunci konvensional juga lebih mudah diduplikat dan kurang praktis. Kekurangan-kekurangan pada sistem kunci konvensional tersebut dapat diatasi dengan beralih ke sistem kunci digital. Peneliti merancang dan membangun sistem smart door double lock yang dapat diakses menggunakan irama ketukan dan NUID pada RFID tag. Kunci pintu ada sistem ini juga diakses menggunakan ponsel android berbasis teknologi IoT. Selain itu, smart door double lock  ini juga dapat mendeteksi adanya tindakan pembobolan dan langsung mengirimkan notifikasi kondisi anomali ke ponsel pengguna. Penelitian dilakukan dalam empat tahapan, yaitu persiapan, perancangan sistem, pembangunan sistem, dan pengujian sistem untuk mendapatkan karakterisasi dari sistem yang dibuat. Untuk dapat menghasilkan sistem yang sesuai, tahap perancangan sistem dibagi menjadi beberapa jenis diagram dan desain sistem, meliputi diagram blok, diagram pengkabelan, diagram skematik, desain prototipe 3D, dan desain antarmuka teknologi IoT. Dalam penelitian ini, sistem telah berhasil dibangun dan dapat berjalan dengan karakteristik statik berupa error sebesar 0% dan akurasi serta presisi sebesar 100% sehingga dapat dikatakan bahwa sistem telah berjalan dengan baik. Kebutuhan daya listrik dalam kondisi aktif stand by sebesar 1,788 W – 2,652 W, dan kebutuhan daya listrik ketika sistem aktif bekerja selama ±6 detik sebesar 6,960 W – 8,016 W.
Ikan Louhan : Spesies Invasif Di Perairan Sekitar Fakultas Perikanan dan Ilmu Kelautan, Universitas Jenderal Soedirman
Authors: Gani Ariya Abdul , Dadiono Muh. Sulaiman
Published: December 2024

Ikan louhan / Flowerhorn cichlid adalah spesies invasif yang dapat merusak ekosistem lokal. Ikan louhan merupakan ikan predator pendatang yang telah lama ditemukan di perairan Indonesia seperti di Danau Matano dan Waduk Sempor. Penelitian ini bertujuan untuk mengkaji dampak negatif ikan louhan di perairan sekitar Fakultas Perikanan Dan Ilmu Kelautan Universitas Jenderal Soedirman dan memberikan informasi mengenai pencegahan kepunahan ikan lokal akibat spesies invasif. Metode yang digunakan meliputi studi literatur (desk study) dan wawancara dengan narasumberl. Data dianalisis secara deskriptif berdasarkan referensi yang berasal dari Google dengan kata kunci di pencarian mesin pencari “ikan louhan” atau “flowerhorn cichlid”. Hasil menunjukkan bahwa ikan louhan yang tertangkap memiliki ciri fisik berbeda yaitu mempunyai corak garis hitam vertikal pada badannya yang menyerupai ikan nila hitam dan berpotensi untuk menghasilkan keturunan hibrida yang lebih kuat dan agresif, yang dapat mendominasi spesies asli. Dampak ekologis ikan louhan meliputi perubahan struktur rantai makanan dan penurunan drastis populasi ikan lokal. Untuk mencegah kerusakan lebih lanjut, diperlukan strategi pengendalian seperti penangkapan rutin, edukasi publik, dan pemantauan ekosistem secara berkala. Hasil ini penting karena memberikan dasar bagi pengambilan keputusan dalam pengelolaan dan perlindungan keanekaragaman hayati di perairan lokal yang terancam oleh ikan invasif seperti ikan louhan.
Analisis Vegetasi Mangrove Berdasarkan Karakteristik Sedimen di Muara Kali Ijo, Kebumen
Authors: Syaukani Hildatul Fajariah , Hendrayana Hendrayana , Kurniawati Any
Published: December 2024

Kawasan Ekosistem Esensial (KEE) Mangrove Muara Kali Ijo merupakan kawasan ekosistem mangrove hasil rehabilitasi yang terletak di Desa Ayah, Kabupaten Kebumen. Komposisi jenis dan kerapatan mangrove berbeda-beda berdasarkan kondisi tekstur sedimen. Tujuan dari penelitian ini yaitu untuk mengetahui nilai kerapatan, jenis fraksi sedimen, dan kerapatan mangrove berdasarkan karakteristik fraksi sedimen. Penelitian ini dilakukan di mangrove Muara Kali Ijo, Desa Ayah, Kabupaten Kebumen pada bulan Desember 2023. Analisis data yang dilakukan yaitu analisis deskriptif. Hasil penelitian menunjukkan bahwa tingkat kerapatan mangrove di Muara Kali Ijo termasuk kedalam kategori sedang hingga sangat baik (zona depan), kategori baik hingga sangat baik (zona tengah) dan kategori sedang hingga sangat baik (zona belakang). Kerapatan jenis mangrove tertinggi didapat pada jenis mangrove Rhizophora mucronata (2.546 ind/ha) yang dapat ditemukan disetiap zona dan terendah pada jenis Rhizophora stylosa (60 ind/ha). Jenis fraksi sedimen mangrove yang ditemukan meliputi pasir kasar, pasir sangat halus, debu kasar, debu halus, liat kasar, dan liat halus. Jenis fraksi zona depan yaitu liat berdebu dengan kriteria kerapatan mangrove sedang hingga sangat baik, fraksi zona tengah liat berpasir dengan kriteria kerapatan mangrove baik hingga sangat baik, dan fraksi zona belakang liat bededu dengan kriteria kerapatan mangrove sedang hingga baik.
Sistem Informasi Pengolahan Data Nilai Raport Terintegrasi di PAUD
Authors: Rachman Andi Nur , Gufroni Acep Irham , Sulastri Heni , Dewi Euis Nur Fitriani
Published: December 2024

Developments in technology and science have had a big effect on life, including in the field of education. Many schools from high school, middle school, elementary school, even kindergarten or PAUD are developing themselves to provide quality learning or educational services by implementing computer-based information systems. The current problem is that the recording of report card scores as a child's development is done manually or written in a report card, this makes it difficult to find out the child's development graph. So there is a need for a system that helps facilitate the assessment of report cards and progress charts preschool children's education. The method used in this service is a descriptive research design method. Service activities in the system development process that will be proposed are the waterfall method. An integrated report card data processing information system to make things easier for PAUD schools. The information system makes things easier for students or parents in checking report scores via the website..
Philanthropy Under Uncertainty: Muslim Religious Giving During the COVID-19 Pandemic
Authors: Umarji Osman , Wasif Rafeel , Siddiqui Shariq , Noor Zeeshan
Published: December 2024

This study investigates the demographic, religious, and psychological correlates of charitable giving during times of uncertainty. We employ structural equation modeling to understand the mechanisms that underlie faith-based philanthropy amongst Muslims. For this purpose, we analyzed Muslim American philanthropy during the month of Ramadan in 2020, a month traditionally associated with increased religiosity and philanthropy. Utilizing a sample of 1,722 Muslims in the United States and Canada, uncertainty intolerance was associated with financial anxiety (B = .26), which in turn was related to donating less money (B = -.06). Financial anxiety was also associated with subjective financial well-being (B =.-.22), which was associated with donations (B = .11). We also found that income (B = .23), education (B = .30), and age (B = .28) positively predicted charitable giving. Increased religious practice (B = .07), such as prayer and reading scripture, was also associated with donating more money. Our results add valuable insights to the literature about the predictors and mediators of religious giving and philanthropy under uncertainty.
IMPLEMENTASI ASAS IN BEZIT STELLING PADA CASH COLLATERAL SEBAGAI JAMINAN ATAS PERJANJIAN KREDIT (Studi PT. Bank Rakyat Indonesia (PERSERO) KC Bojonegoro)
Authors: Permata Khoirunnisa Diyah , Nugraheni Anjar Sri Ciptorukmi
Published: December 2024

Abstract

This Articles aims to analyze the implementation of in bezit stelling principle on cash collateral as collateral for credit agreements and the execution of cash collateral by analyze first the implementation of credit agreements. This study belongs to empirical law research that is descriptive in nature. The data was obtained from primary and secondary data. Considering the result of research and discussion Based on the results of the research and discussion, a conclusion was made regarding the implementation of in bezit stelling principle on cash collateral at BRI Bojonegoro Branch Office and execution of cash collateral, credit loans use cash collateral tied to a mortgage agreement to ensure repayment of debtor debt, There is a surrender of cash collateral as a real delivery which is the legal amount of the mortgage along with the blocking of the credit. Creditor also has preference right, namely the right to precedence in the term of debt repayment over object execution result becoming the mortgage collateral objects against other creditor. If when the debtor makes a default, then BRI Bojonegoro Branch Office execute directly (parate execution) against cash collateral. Execution may be made by withdrawal for payment of debtor debt.
EFEKTIVITAS PERLINDUNGAN HUKUM HAK CIPTA MUSIK YANG DIADAPTASI OLEH DISJOKI UNTUK KONSER BERBAYAR
Authors: Hakim Satria Sulton , . Pranoto
Published: December 2024

Artikel ini dilakukan dengan tujuan untuk mengidentifikasi apakah problematika perlindungan hukum musik di Indonesia yang menyebabkan pelanggaran hak cipta tersbut terjadi terus menerus dan bagaimana perlindungan hukum bagi pemegang hak cipta apabila lagunya diadaptasi oleh Disjoki untuk konser berbayar tanpa seiijin pemilik hak cipta. Metode yang digunakan dalam artikel ini adalah penelitian hukum empiris, yaitu suatu penelitian hukum yang dilaksanakan dengan cara meneliti bahan Kemudian, pendekatan yang digunakan penulis dalam artikel ini adalah pendekatan perundang-undangan (statue approach), dan pendekatan konseptual (conceptual approach), dengan jenis data yang terdiri dari data primer dan sekunder. Teknik analisis data yang digunakan yakni berupa reduksi data, penyampaian data dan menarik.  Hasil dari penelitian ini adalah pelanggaran terus-menerus terjadi khususnya terkait hak cipta lagu dan/atau musik bidang performing right, dikarenakanbudaya hukum masyarakat Indonesia yang kurang memberikan penghargaan terhadap para pencipta dan karya ciptanya. Kemudian terhadap setiap pelanggaran hak cipta berupa ketiadaan izin tersebut diatas, oleh Undang- undang Hak Cipta telah memberikan perlindungan kepada pencipta berupa gugatan ganti rugi secara perdata serta adanya hak negara untuk melakukan penuntutan secara pidana.
PERLINDUNGAN HUKUM TERHADAP PENERIMA PINJAMAN FINTECH LENDING AKIBAT PELANGGARAN ASAS KEAMANAN DAN KESELAMATAN OLEH PENYELENGGARA
Authors: Armelita Dinda , . Suraji
Published: December 2024

Artikel ini bertujuan untuk menjelaskan perlindungan hukum terhadap penerima pinjaman Fintech Lending akibat pelanggaran asas keamanan dan keselamatan oleh penyelenggara dalam hal penagihan pinjaman yang kerap dilakukan dengan pencemaran nama baik dan ancaman. Penelitian ini merupakan penelitian hukum normatif yang bersifat preskriptif dengan pendekatan perundang-undangan (statute approach) dan pendekatan konseptual (conceptual approach). Sumber bahan hukum diperoleh dari bahan hukum primer dan bahan hukum sekunder menggunakan teknik pengumpulan bahan hukum studi pustaka (library research) dengan cara mengunduh (download), menyalin (copy), mengoleksi literatur yang berupa buku-buku atau jurnal kemudian mengkualifikasi bahan hukum. Selanjutnya dianalisis menggunakan metode silogisme dengan pola berpikir deduktif. Hasil penelitian menunjukkan penerima pinjaman dapat diberikan perlindungan hukum secara internal maupun eksternal. Perlindungan hukum internal yaitu dengan dibuatnya perjanjian elektronik antara pemberi pinjaman dengan penerima pinjaman yang memuat hak dan kewajiban para pihak dalam perjanjian, sedangkan Perlindungan hukum eksternal yaitu adanya regulasi yang dibuat pemerintah melalui Otoritas Jasa Keuangan mengeluarkan Peraturan Otoritas Jasa Keuangan Nomor 1/POJK.07/2013 tentang Perlindungan Konsumen Sektor Jasa Keuangan dan dengan penyelenggara menerapkan prinsip-prinsip fintech lending yang diatur dalam Pasal 29 POJK Nomor 77/POJK.01/2016 tentang Layanan Pinjam Meminjam Uang Berbasis Teknologi Informasi
IMPLEMENTATION OF THE SETTLEMENT OF MSME BAD LOANS BASED ON POJK NUMBER 11 OF 2020 DUE TO THE COVID-19 PANDEMIC (STUDY AT PT. BANK RAKYAT INDONESIA (PERSERO) TBK SURAKARTA)
Authors: Izdihar Raihan Ade , Imanullah Moch. Najib
Published: December 2024

This article aims to review legal issues regarding the implementation of the settlement of MSME bad loans based on Financial Services Authority (POJK) Regulation Number 11 of 2020 at PT. Bank Rakyat Indonesia and constraints in the implementation of bad credit settlement due to Covid-19 and alternative solutions. To achieve this goal, then empirical legal research is conducted which is descriptive The data type in this study consists of primary data obtained directly from the field and secondary data obtained from the results of literature study. The primary data collection technique used is to use interview techniques, while secondary data collection techniques use downloading and collecting necessary legal materials. The data analysis techniques used are interactive analysis models. The results of this research and study, show that the implementation of economic recovery policy issued by the government has been applied well by Bank BRI, especially for Micro, Small, and Medium Enterprises  (MSMEs) debtors. The form of restructuring conducted by Bank BRI Surakarta is by lowering interest rates and extending the installment period. Government policy by issuing a credit relaxation policy is a very appropriate step, especially for debtors of Micro, Small, and Medium Enterprises or MSMEs of Bank BRI Surakarta. The settlement of bad loans due to the Covid-19 pandemic at Bank BRI Surakarta has been implemented based on The Financial Services Authority (POJK) Regulation Number 11 of 2020 on The Stimulus Impact of Covid-19. An alternative solution to the constraints of the implementation of bad credit settlement due to Covid-19 is the launch of the Economic Recovery Program (PEN) through the Regulation of the Financial Services Authority (POJK) Number 11 of 2020 on Stimulus Impact of Covid-19. State-owned banks, in this case Bank BRI Surakarta has helped MSME debtors affected by Covid-19
PERLINDUNGAN HUKUM BAGI PENERIMA PINJAMAN DALAM MENGGUNAKAN PEER TO PEER LENDING
Authors: Sirait Gabriella Hosianna , Sudarwanto Albertus Sentot
Published: December 2024

Artikel ini bertujuan untuk mengkaji dan menganalisis perlindungan hukum terhadap penerima pinjaman dalam menggunakan layanan peer to peer lending. Penelitian ini adalah  penelitian  empiris  bersifat  deskriptif.  Sumber  data penelitian  ini  didapat dengan melakukan wawancara terhadap penerima pinjaman peer to peer lending, penyelenggara peer to peer lending, dan Otoritas Jasa Keuangan. Hasil penelitian menunjukkan bahwa dalam mengajukan pinjaman, penerima pinjaman sering kali merasa dirugikan oleh penyelenggara atau penyedia layananan. Perlindungan hukum yang dapat diperoleh oleh penerima pinjaman yaitu perlindungan hukum secara preventif dan represif. Perlindungan hukum secara preventif bersumber dari Undang-Undang Perlindungan Konsumen,Peraturan Otoritas Jasa Keuangan, dan perlindungan hukum yang berasal dari penyelenggara pinjaman. Perlindungan hukum secara represif yaitu penyelesaian sengketa melalui jalur litigasi maupun non litigasi
TRANSPARANSI PADA LAYANAN PERUSAHAAN ASURANSI KESEHATAN DITINJAU DARI ASPEK HUKUM PERLINDUNGAN KONSUMEN
Authors: Hutagalung Fuad Dicky
Published: December 2024

This article aims to examine the importance of transparency in health insurance company services from the perspective of consumer protection law. This research is a doctrinal research that studies the purpose of law, the values of justice, the validity of legal rules, legal concepts and legal norms. The results showed that health services are very important basic needs and human rights of every individual. The quality of health services has a significant effect on the degree of public health. Access to quality and affordable health services is a must, with information transparency as the main indicator. This transparency is important to increase consumer efficiency in choosing products and to increase loyalty to certain products. The Consumer Protection Law (Law No. 8 of 1999) and the Insurance Law regulate the obligations of insurance companies in providing accurate and complete information, as well as ensuring fairness in the claims process and handling consumer complaints Insurance companies must manage premium funds wisely and transparently, and engage and educate consumers about their rights. Open and transparent communication with consumers is essential to build trust. Consumer protection can also be enhanced through cooperation between the government, insurance companies, healthcare providers, and consumer organizations. By consistently carrying out these obligations, the healthcare and insurance industries can build a good reputation and gain the trust of the public.
Medical and social characteristics of doctors recognized as disabled for the first time in the Irkutsk region
Authors: Rybchenko N. V. , Vladimirova O. N. , Afonina K. P. , Butko D. Yu. , Goryainov I. V.
Published: December 2024

Introduction. The problem of disability of doctors is the most important indicator of public health, since doctors solve an important task of state policy aimed at maintaining public health, which determines the study and analysis of the disability status of this contingent of specialists.

The purpose of the study: analysis of factors that shape the medical and social portrait of doctors who have been diagnosed with a disability for the ﬁrst time. Task. To explore the medical and social characteristics of doctors who are ﬁrst recognized as disabled in the Irkutsk region in 2021–2023.

Materials and methods. Subject of the study: 400 citizens who were recognized as disabled for the ﬁrst time in the Federal State Institution «Main Bureau of Medical and Social Expertise in the Irkutsk Region» in 2021–2023. Of these, 174 people are doctors. The study is selective. Selection criteria: persons recognized as disabled for the ﬁrst time in the Irkutsk region in 2021–2023, working at the time of examination in their specialty. Sources: form 7-social security. Research methods: documentary, analytical, statistical.

Results. In the structure of those ﬁrst recognized as disabled among doctors, women predominate by gender, while men predominate in the control group, and the average age of initial recognition as disabled in the main group is older than in the control group. Most often, the III group of disability is established in the main and control group, the most rarely – I. Three main classes of diseases form more than 75,0% of primary disability in the Irkutsk region, and disability due to malignant neoplasms in the medical contingent is found slightly more often, and due to diseases of the circulatory system – somewhat less often than in the control group. Most often, in the ﬁrst-recognized person in the main and control group, restrictions on the ability to self-service, movement and work in their various combinations were revealed.

Conclusion. Among doctors from among the factors that were ﬁrst recognized by people with disabilities, forming their medical and social portrait, were the female gender, the age of 55 years and older, the presence of a «light» group III of disability due to malignant neoplasms. The primary disability of doctors was most often established due to persistent disorders of the function of the blood system and the immune system, with a limitation of the ability to independently maintain, movement and work.
Análisis de videojuegos comerciales para el desarrollo de prácticas científicas y habilidades socioemocionales en la escuela primaria
Authors: Suarez Viviana Irma , Martín Rocio Belen , Occelli Maricel
Published: December 2024

Con el objetivo de identificar videojuegos comerciales como mediadores para la enseñanza de las ciencias naturales, fortaleciendo prácticas científicas y habilidades socioemocionales, en el segundo ciclo nivel primario, se desarrolla un análisis documental, con la aplicación del modelo construido ad hoc, formando parte de un estudio más amplio. De los resultados se observa en las Dimensiones jugabilidad intrínseca (técnica) y mecánica, que todos pueden ser utilizados en las diferentes plataformas, la mayoría pertenece al género mixto con los objetivos y características dentro de la narrativa y presenta un avatar. En las Dimensiones jugabilidad interactiva- interpersonal y artística- intrapersonal, se detectan entre otros, factores concernientes con las habilidades socioemocionales. La mayoría evidenció la presencia de recompensas intrínsecas (habilidad de relacionarse y autonomía) y extrínsecas. En referencia a percepciones del jugador, escenario y sentimientos que se desencadenan: satisfacción, inmersión, etc. la mayoría de estos videojuegos los promueve con escenarios de realidad autogenerada y en primera persona. La Dimensión didáctica: prácticas científicas en su categoría indagación admiten observación y manipulación de variables, estimulan la formulación de preguntas, exploración del contexto y emisión de hipótesis/supuestos. En cuanto a la categoría modelización, menos de la mitad de los videojuegos representa entidades o fenómenos y en todos los escenarios y narrativas favorecerían la argumentación, el uso e identificación de pruebas, justificar acciones y elaborar conclusiones.
 
Palabras clave: Ciencias de la naturaleza, Afectividad y sentimiento, Aprendizaje, Juego de ordenador
Juegos de mesa para la didáctica de la lengua y la literatura: una propuesta taxonómica
Authors: Samper Cerdán María , Acosta Carla , Juan Penalva Joaquín , Rovira Collado José
Published: December 2024

Las posibilidades del juego han sido estudiadas desde diversas disciplinas, incluyendo la Antropología, la Psicología y la que nos ocupa: la Didáctica. El Aprendizaje Basado en Juegos (ABJ) consiste en una metodología activa en la que se utilizan juegos en un contexto educativo con objetivos de aprendizaje específicos. Dentro del ABJ, existen numerosos estudios que se centran en las contribuciones de los videojuegos; sin embargo, las peculiaridades de los juegos de mesa parecen ser un territorio aún por explorar. Este estudio tiene como objetivo identificar los componentes literarios y narrativos presentes en los juegos de mesa mediante el análisis de varios títulos y sus posibilidades específicas dentro de la Didáctica de la Literatura. Así, se pretende extraer una serie de conclusiones que ayuden a crear una clasificación inicial de los juegos de mesa basada en sus características narrativas y literarias, formando una propuesta que sirva como guía y recomendación para los docentes que decidan llevar los juegos de mesa a sus aulas.
The Randwick Wap: A Custom of Community
Authors: Lloyd May Jessica J.
Published: December 2024

On 7 May 2022 a crowd formed around the war memorial in the village of Randwick, Gloucestershire. The crowd grew in numbers and in excitement, with photographers from local news outlets manoeuvring to capture the event. It was the second Saturday of May which, for the inhabitants of Randwick and the surrounding villages, meant that it was the day of the Wap. Through qualitative interviews with organisers, participants, and attendees, as well as field work observations of the Wap and its contemporary format, I will show the custom’s importance in the local cultural calendar and investigate how it has become entwined with the village’s identity. I will focus directly on the community, through first-hand accounts and use the words of the respondents to explain the ongoing importance of this custom and others like it.
A Phase-State-Radius-Based Multiphase-State Identification Acceleration Approach of the Hydrocarbons-CO2-H2O System for Compositional Reservoir Simulation
Authors: Yuan Bin , Huang Gang , Zhang Wei , Dindoruk Birol
Published: December 2024

The CO2-enhanced oil recovery (CO2-EOR) technique could increase the oil recovery factor and achieve subsurface CO2 storage. To evaluate the feasibility of CO2-EOR operation, an equation-of-state-based (EOS-based) compositional simulation is inevitable. However, time-consuming multiphase flash calculations limit the application of the conventional EOS-based compositional simulation in large-scale reservoir simulations. Therefore, there is an urgent need to accelerate the EOS-based compositional simulation by reducing the time spent on the multiphase flash calculations.

In this study, we develop a fast, multiphase-state identification approach to achieve high computational efficiency of the compositional simulation. First, taking one given point in the compositional space composed by pressure and the overall composition as the original point, the phase-state radius (PSR) is defined as a radius inside which all points have the same phase state as the given point. Subsequently, the results of the multiphase flash calculations of the points in the compositional space are stored. Finally, when a new point is inside the PSR of one calculated point, the stored results are used to accelerate the new multiphase flash calculations of the new point by omitting the phase stability analysis (PSA) and possible additional multiphase split (MS) calculations. Case studies show a 6–10% reduction in multiphase flash computation time compared with two existing methods when the fluid is far from the phase boundary and a reduction of at least 17.5% when the fluid is near the phase boundary.
True Triaxial Laboratory Study of the Strain Patterns Measured by Distributed Fiber Optics for Hydraulic Fracturing of Multilevel Horizontal Wells
Authors: Guo Tiankui , Zhang Yuanhang , Chen Ming , Liu Yongzan , Qu Zhanqing , Dai Caili , Zhang Bo , Hu Zunpeng , Xue Linrui
Published: December 2024

As the exploitation of oil and natural gas has progressed, hydraulic fracturing has become a primary method for increasing oilfield production. Simultaneous hydraulic fracturing of several perforation clusters, by employing limited-entry methods, has become standard in horizontal well stimulation. However, challenges such as unclear fracture identification and limited monitoring methods persist in hydraulic fracturing. This study integrates an optical frequency domain reflector with true triaxial fracturing of multilevel horizontal wells to develop a physical simulation system for monitoring fractures in a laboratory setting via distributed fiber optics. By employing fiber optics, dynamic monitoring of fractures during the fracturing process of multilevel horizontal wells can be achieved. The results indicate that monitoring with distributed fiber optics can clearly record data and accurately determine the initiation points of fractures. The strain data induced by the fractures on the fibers can be interpreted to deduce the fracture width. If a fracture deflects upon encountering a fiber, the fiber will exhibit tensile strain within an abnormal range. When using distributed fiber optics for monitoring fractures in multilevel horizontal wells, it is crucial to optimize the placement of fractures to ensure that the signals detected by the fibers are complete and avoid signal loss. In this paper, we demonstrate the feasibility of using distributed fiber optics for fracture monitoring in multilevel horizontal well fracturing experiments, overcoming the limitations of current single-method approaches to monitoring laboratory true triaxial hydraulic fractures.
Secure in the Dark? An In-Depth Analysis of Dark Web Markets Security
Authors: Wang Yichao , Arief Budi , Hernandez-Castro Julio
Published: December 2024

As the name implies, dark web markets – also commonly known as anonymous markets – have put in place measures for protecting the privacy of its users, both sellers and buyers, as this is a key priority that can attract users worldwide. With the rapid growth of dark web markets, competition between them has become more intense. In this environment, malicious attacks targeting competitors – for instance, aimed at reducing the availability of rivals' services – have also become more common. These attacks not only affect other services' availability and accessibility, but they may also lead to personal and private information being leaked. As such, it is understandable that dark web markets may want to implement strong security mechanisms to protect themselves and their users both from law enforcement and other operators. This is particularly true as good security can bea matter of survival but also help to gain a competitive edge over rivals. Although the literature has analysed and described dark web markets from multiple perspectives, there is still a gap in understanding the different security mechanisms they deploy. Furthermore, data collection – which is often considered a challenge in this research area – may be hindered by these very security mechanisms. Therefore, and in order to cover this gap, the study presented in this paper aims to investigate in depth the security mechanisms of various dark web markets. This will hopefully help to shed a brighter light on their operation. To achieve this, we performed data collection and experiments in twelve dark web markets. Although data collection practices may need to vary slightly for each market, all the data was collected over the span of four months, between May and August 2023. We found there are three main groups of security mechanisms in dark web markets: (i) those aimed towards increasing web security, (ii) those mostly aimed at improving account security, and (iii) those related to financial security. In addition, it is interesting to note that different types of security mechanisms on a given market may reflect the operator's business philosophy, technical knowledge and security posture, which in turn could have a big impact on the longevity, profitability and overall success of a particular market . The results of this study can help the academic and security research communities to understand the operation and evolution of dark web markets, hopefully to combat the crimes facilitated by these dark web markets more effectively. Additionally, findings in this study may provide some clues on how to improve the efficiency of data collection in this particularly hostile environment.
Finite Element Analysis of Pullout Resistance and Progressive Failure of Strip Anchors in Strain-Softening Soils based on the Cosserat Continuum Method
Authors: Ye Xiangji , Wei Wencheng , Zhang Heng , Ji Zezhou , Tang Hongxiang , zhao Xin
Published: December 2024

Given the limited research on regularization mechanisms in finite element analysis of the ultimate pullout resistance of plate anchors, particularly considering soil strain softening, this paper employs a Cosserat continuum regularization mechanism combined with a Mohr-Coulomb matched Drucker-Prager constitutive model (MC-matched DP model) to address this issue. Implementing the User-Defined Element (UEL) function in ABAQUS, the numerical solution was developed and validated against existing literature to verify the accuracy of the MC-matched DP model for analyzing plate anchor pullout resistance. This study demonstrates that the Cosserat continuum model effectively resolves common issues such as numerical convergence difficulties and mesh dependency encountered in finite element calculations for softening soils. Subsequently, the model was applied to conduct a detailed analysis of the ultimate pullout resistance of plate anchors and the progressive failure process of the soil. Parametric analyses were performed to explore the combined effects of plate anchor inclination, burial depth, and degree of strain softening on ultimate resistance and failure mechanisms. Based on these analyses, an expression for the ultimate resistance coefficient Nc, incorporating the influences of plate anchor inclination, burial depth, and strain softening, was formulated, providing a valuable reference for geotechnical engineers in practical applications.
Performances of cement-based materials incorporating new SCMs produced by the co-calcination of construction wastes with waste dolomite powder
Authors: chen deng , Lu Ji-da , Mo Li-wu , Liu Kai-wei , Wang Ai-guo , Yang Tao
Published: December 2024

In this study, new types of supplementary cementitious materials (SCMs) were manufactured by the calcination of construction wastes such as engineering muck (EM) and waste brick (WB) in the presence of waste dolomite powder (WDP). The impacts of calcined dolomite-muck (CDM) and calcined dolomite-brick (CDB) on the performances of Portland cement were investigated, the reaction mechanism of CDM and CDB in pastes was also analyzed. Results showed that the mineral compositions of CDM and CDB are β-C2S, periclase, quartz and merwinite. The incorporations of CDM and CDB decreased obviously the hydration heat and strengths of cement-based materials at early stages. However, the blended cement mortars with 10-20% CDM and CDB obtained similar or higher strengths at later stages compared to the control mortar. This is attributed to the hydration of β-C2S in CDM and CDB, resulting in the pore structure densification and the lower porosity at later ages. In addition, the mortars with CDM and CDB also produced gentle expansions attributed to the hydration of periclase in CDM and CDB, which is beneficial for mitigating the shrinkage.
Exploring the Antimicrobial Potential of New Selenium- N-Heterocyclic Carbene Complexes and Their Benzimidazolium Salts: Synthesis, Characterization, Biological Evaluation, and Docking Insights
Authors: BOUALIA Boutheina , SANDELI Abd elkrim , BOULEBD Houssem , KARCI Hüseyin , DUNDAR Muhammed , ÖZDEMIR İlknur , Gürbüz Nevin , Koç Ahmet , MENACER Rafik , ÖZDEMIR İsmail
Published: December 2024

The present work, describes the synthesis and antimicrobial evaluation of new selenium-NHC adducts (3a-e) and their corresponding benzimidazolium salts (2a-e). Specific synthetic approaches were employed, resulting in compounds with satisfactory stability under humid and aerated conditions. Characterization by spectroscopic methods confirmed structural changes upon selenium incorporation. Biological evaluations revealed varying antimicrobial and antifungal activities among the synthesized compounds. The results indicated that the benzimidazolium salts exhibited significantly enhanced antimicrobial and antifungal activities compared to reference agents. For instance, compound 2a demonstrated an IC50 value of 6.25 µg/mL against Candida albicans, which was comparable to the reference Caspofungin (6.25 µg/mL).
Similarly, compound 2e demonstrated strong antibacterial activity against Staphylococcus aureus, with an IC50 value of 0.8 µg/mL, significantly outperforming the reference Ampicillin (1.56 µg/mL). In contrast, the selenium-NHC adducts exhibited moderate to minimal activity, with compound 3e showing the highest IC50 value of 25 µg/mL against Staphylococcus aureus, but failing to surpass the activity of the reference agent. To explore the potential mechanism of action, molecular docking studies were conducted against E. coli DNA gyrase and CYP51. The molecular docking results demonstrate that synthesized compounds exhibit significant binding affinity against both enzymes, indicating antibacterial and antifungal potential. These binding affinities suggest that these molecules could be effective dual-action antimicrobial agents.
Clinical Utility of Comprehensive Genomic Profiling for Advanced Pancreatic Cancer: Insights from Real-World Data Analysis
Authors: So Eiichiro , Hayashi Hideyuki , Shimozaki Keitaro , Horie Sara , Kishimoto Shotaro , Chida Akihiko , Saito Yuki , Tsugaru Kai , Hirata Kenro , Tanishima Shigeki , Nishihara Hiroshi , Kanai Takanori , Hamamoto Yasuo
Published: December 2024

Background
Precision medicine is a promising therapeutic strategy for pancreatic cancer. However, only a few patients are eligible for genotype-matched treatments because of the low detection rate of actionable genomic alterations, and the clinical application of comprehensive genomic profiling (CGP) in pancreatic cancer has not been completely investigated. CGP provides considerable information, such as data on prognosis and future eligibility of patients for genotype-matched clinical trials, and can eventually guide physicians’ treatment strategies. This study aimed to investigate the contribution of CGP to patient outcomes.
Methods
This single-center retrospective cohort study enrolled patients diagnosed with recurrent or metastatic pancreatic cancer with adenocarcinoma or adenosquamous carcinoma who underwent systemic chemotherapy between April 2018 and April 2022. We reviewed medical records and collected data on patient characteristics, survival, and genomic information. We compared overall survival (OS) between patients who received CGP (CGP group) and those who did not (non-CGP group).
Results
Overall, 111 patients were eligible, of which 59 underwent CGP. No significant differences were observed in patient characteristics between the groups. The median OS was significantly longer in the CGP group than in the non-CGP group (25.2 vs. 11.8 months; hazard ratio, 0.49; 95% confidence interval, 0.31–0.76; P = 0.0013). Actionable genomic alterations were detected in 24 patients (40.7%), and six patients (10.2%) underwent genotype-matched treatments.
Conclusions
OS was extended in patients with pancreatic cancer who underwent CGP, possibly due to its influence on physicians’ treatment strategies. This result highlights the need for proactive and timely CGP for patients with pancreatic cancer.
Long non-coding RNA MALAT1 promotes the proliferation and metastasis of lung cancer by regulating FUT4 and α1,3-fucosylated glycans mediated via the PI3K/Akt signaling pathway
Authors: Alshwmi Mohammed , Li Shijun , Saleem Muhammad , Ahmed Faisal , Yingxin Wang , Juebin Gu , Badheeb Mohamed
Published: December 2024

In this study, we investigate the role of MALAT1 in NSCLC and its potential interactions with FUT4 in promoting the progression, proliferation, and metastasis of NSCLC cell lines. MALAT1 expression was assessed using quantitative PCR (qPCR) while FUT4 expression was measured using qPCR, enzyme-linked immunosorbent assay (ELISA), and Western blotting in both serum and tissue samples. To confirm the regulatory role of MALAT1 in FUT4 expression, Western blotting, qPCR, and immunofluorescence techniques were employed in A549 and H1299 cell lines. LeY in the epidermal growth factor receptor was detected using Immunoprecipitation. We found that MALAT1 and FUT4 expressions were higher in the serum and tissues of NSCLC patients. MALAT1 led to increasing FUT4 expression and tumor growth as well as metastasis in A549 and H1299 cells. Our findings indicated that MALAT1 upregulated FUT4 expression through the PI3K/Akt signaling pathway, increasing tumor growth, and metastasis in lung cancer. MALAT1 knockdown in lung cancer cells inhibited FUT4 expression, suppressing cell proliferation and metastasis. Our study suggested that LncRNA MALAT1 promotes proliferation and metastasis via targeting FUT4 by enhancing α1,3-fucosylation and LeY biosynthesis of glycoproteins. MALAT1 and FUT4 can therefore be potential diagnostic and therapeutic targets in lung cancer.