bluuebunny/crossref_metadata_2025 huggingface dataset:
Neverbalna komunikacija kao alat uvjeravanja u javnom nastupu
Authors: Borovac Zekan Senka , Gabrić Katarina
Published: December 2021

U svakodnevnoj komunikaciji,
svjesno ili nesvjesno, koristimo se neverbalnom komunikacijom kako bismo
prenijeli poruku sugovorniku na što efektivniji način, izrazili emocije,
dojmove ili ga uvjerili u vlastite stavove. Neverbalna komunikacija
podrazumijeva kontakt očima, izraz lica, stav i položaj tijela, gestikulaciju
rukama, ton glasa kao i dodir. Osobni izgled također spada u jednu vrstu
neverbalne komunikacije. Stil odijevanja ostavlja dojam na sugovornike koji
može imati veliki utjecaj na cjelokupno izlaganje. Javni govor podrazumijeva
izlaganje određenih informacija većoj skupini slušatelja. Takvo izlaganje može
biti pripremljeno, nepripremljeno, formalno, neformalno, spontano ili pak
strukturirano. Kod javnog govora osim verbalnih veliki značaj imaju i neverbalni
parametri izlaganja. Oni predstavljaju ključan alat korišten kako bi, ne samo
uvjerili slušatelje u pouzdanost i ispravnost onoga što se govori, već kako bi
pridobili njihovu pažnju sa ciljem da interes slušatelja ostane prisutan
tijekom cijelog izlaganja. Iz navedenog razloga neverbalna komunikacija je
izuzetno bitna kao predmet izučavanja u sklopu tematike javnog nastupa. Ukupna
neverbalna komunikacija kao i govorne sposobnosti mogu se vježbanjem usavršiti.
Korištenjem različitih tehnika uvjeravanja moguće je utjecati na slušatelje i
približiti im stavove i poruku koja im se pokušava prenijeti. Ovim radom
nastojao se istražiti utjecaj neverbalne komunikacije kao alata uvjeravanja u
javnom nastupu. U radu se analizira kakav i koliki utjecaj ima neverbalno
izražavanje na cjelokupni dojam o govorniku. Empirijski dio rada temelji se na
analizi mišljenja i stavova ispitanika prikupljenih anketom o neverbalnoj
komunikaciji. Rezultati dobiveni obradom anketnog upitnika ukazuju kako
neverbalno izražavanje ima znatan utjecaj na cjelokupni dojam o osobi koja
javnim govorom prenosi određenu poruku. Stečeni dojam u konačnici može ostaviti
generalno negativan ili pozitivan stav o govorniku te se potvrdila činjenica
kako neverbalna komunikacija često ostavlja snažniji dojam na stav slušatelja o
govorniku od verbalne komunikacije.
Specific Features of Luxury Products Branding
Authors: Krajnović Aleksandra , Bosna Jurica , Grubišić Sara
Published: December 2021

In this modern world characterized by
rapid change, the role of marketing is increasingly important. Developing a
brand is one way in which a competitive advantage can be achieved. The work
defines the concept of luxury through the prism of marketing, shows the
specifics of marketing in the luxury products market and the key factors that
influence the demand for luxury products. The paper found that the key to
success is to effectively create a market strategy whose main goal is to create
a strong and emotional long-term relationship between the brand and the
consumer. Also, the new trend of "abundant rarity" has led companies
in the luxury goods sector to strive to strike an optimal balance between
exclusivity and affordability.
Uloga nacionalnih socijalnih država u očuvanju i zaštiti socijalnih vrijednosti u kontekstu neoliberalnog globalnog poretka
Authors: Kvartuč Domeniko , Kuzelj Valentino , Petrović Tatjana
Published: December 2021

Globalizacija,
kao proces koji teži sveobuhvatnosti i jedinstvenosti svijeta, nameće složeno
pitanje o načinima sukobljavanja s ekonomskim nejednakostima kao posljedicom
neoliberalnog modela integracije svjetskoga tržišta. Imajući na umu
restrukturacijsku prirodu tog procesa, koji se odvija na više razina, dolazi se
do zaključka kako nastali odnosi u svjetskoj trgovinskoj mreži umanjuju značaj
financijske suverenosti nacionalnih država. S obzirom na to, ekonomske
nejednakosti se perpetuiraju, a socijalni instrumenti nacionalnih država su
blokirani zbog umreženosti u globalno tržište koje se odvija po obrascu
neoliberalne paradigme. U radu se izlažu razine na kojima se odvija integracija
globalnoga tržišta (makro, mezo i mikro) te se ističu različiti učinci
globalizacijskoga procesa na razvijene (zapadne) demokracije, tržišna
gospodarstva u nastajanju, zemlje u razvoju te države post-tranzicije iz
socijalizma u demokraciju. Dodatno, ističe se utjecaj ekonomskih procesa i
kriza na ustavne poretke nacionalnih država, što može rezultirati „prešutnom“
izmjenom ustavnih struktura pojedinih država u smjeru rastakanja uloge
zakonodavnog tijela (kao izabranog predstavništva građana) pri kreiranju
ekonomskih, fiskalnih i socijalnih politika. Naposljetku se ukazuje kako je, s
obzirom na nemogućnost jedinstvene regulacije svjetskoga tržišta, mehanizme za
suzbijanje negativnih (socijalnih i ekonomskih) posljedica globalizacijskoga
procesa potrebno pronaći unutar okvira nacionalnih socijalnih država.
Euroskepticizam mladih u Hrvatskoj
Authors: Amanović Mišela , Solenički Martina
Published: December 2021

Financijska kriza iz 2009. godine koja je rezultirala
ekonomskom divergencijom zemalja članica europodručja potaknula je rast
euroskepticizma diljem Europske unije. S očekivanim ulaskom Hrvatske u europodručje
ponovno se aktualiziralo pitanje troškova i koristi europskih integracija. Glavni
cilj rada je istražiti euroskepticizam mladih u Hrvatskoj. Istraživanje je
provedeno na uzorku od 405 mladih. Analiza je provedena korištenjem logističke
regresije. Zavisna varijabla u modelu je binomna varijabla koja opisuje odgovor
ispitanika na pitanje podržavaju li ili ne euro kao službenu valutu u
Hrvatskoj. Rezultati istraživanja ukazuju na to da su značajne odrednice euroskepticizma
mladih u isključivi nacionalni identitet i ekonomska očekivanja. S jedne
strane, ulazak Hrvatske u europodručje dijelom je u suprotnosti s osjećajem privrženosti
vlastitoj državi u kontekstu isključivog nacionalnog identiteta. Drugim
riječima, mladi koji ne smatraju europski identitet dijelom vlastitog
identiteta priklonit će se euroskepticizmu. Druga značajna odrednica
euroskepticizma mladih su ekonomska očekivanja, odnosno njihova procjena prednosti
i nedostataka pridruživanja europodručju. Drugim riječima, mladi formiraju
mišljenje o euru na individualnim i društvenim ekonomskim troškovima eura kao
službene valute, pa će oni koji očekuju više štete nego koristi, biti skloniji
euroskepticizmu. Rezultati istraživanja doprinose boljem razumijevanju
odrednica euroskepticizma mladih u Hrvatskoj te mogu biti poticaj da se dodatno
otvori medijski i društveni prostor za artikulaciju argumenata o koristima, ali
i troškovima budućeg članstva Hrvatske u Ekonomskoj i monetarnoj uniji.
Digital Marketing in Hospitality – Case Study of Social Networks as a Communication Toll in Oporto Hotels
Authors: CUNHA Manuela , Fontes CORREIA Ricardo , COSTA Adriano
Published: December 2021

Digital marketing and social networks are progressively becoming the most important communication tool in almost all business areas. This has considerably increased the information available online. In the tourism context, these developments have had a considerable effect, as they have altered the way tourists search for information, plan trips and share experiences.
Innovative Solutions to Overcome the Health Services Crisis within the Covid-19 Era
Authors: PASCU-GABARA Elena Iuliana , CEPOI Andrei
Published: December 2021

The outbreak of the SARS-CoV-2 pandemic has fundamentally changed the natural course of activity of all economic sectors worldwide, as well as the healthcare sector which was deeply influenced. This paper analyzes the relationship between the increased demand for health services during the pandemic and the limited supply of healthcare using the transversal method for some European Union (EU) states.
The Influence of Entertainment on The Average Stay: Hotel Establishments in Terras De Trás-Os-Montes
Authors: Esteves Elsa , Cabeceiro Daniela
Published: December 2021

The main objective of the present study is to analyze the contribution of entertainment to the average stay in hotel establishments in Terras de Trás-os-Montes (Portugal). In view of the purpose of the study, four specific objectives were considered: i) To identify the type of entertainment activities complementary to the hotel offer; ii) To identify the existence of partnerships with tourist entertainment agents; iii) To identify the activities practiced by guests; iv) To analyze the perception of hotel managers regarding the influence of entertainment on the average stay.
Why lncRNAs were not conserved? Is it for adaptation?
Authors: KARLIK Elif
Published: December 2021

Plants are sessile organisms affected by changing environment, especially biotic and abiotic stress. Long non-coding RNAs (lncRNAs) became prominent as crucial regulators in diverse biological mechanisms, including developmental processes and stress responses such as salinity. In this study, salinity related lncRNAs were sequenced and analyzed according to homology based on rice and maize lncRNA sequences. After sequencing, 72HASATROOT and 72TARMROOT were identified as 568 bp, additionally, 72HASATSHOOT and 72TARMSHOOT were also 568 bp according to reference sequence which are the member of the natural-antisense lncRNA with 565 bp. Besides, 77HASATROOT and 77TARMROOT were identified as 676 and 644 bp, additionally, 77HASATSHOOT and 77TARMSHOOT were 666 bp according to reference sequence alignment that reference sequence was 667 bp and the sno-lncRNA member. Sequencing studies demonstrated sequence alterations resulted in secondary structure changes which may affect the adaptation of varieties in response to stress. As a conclusion, rapid evolution of lncRNAs may be another force for adaptation to changing environment in plants.
Uso da técnica de microagulhamento para cicatriz de acne atrófica: uma revisão integrativa
Authors: Núbia Santos Araújo Allana , Guilherme Campos Lima Pedro , Cunha Carvalho Carolina , Micaelli Rodrigues Cantarelli Deysi , Monteiro de Lima Alves Simone , Cabral Palmeira Aline
Published: December 2021

A acne vulgar é um distúrbio inflamatório que ocorre na unidade pilossebácea e com sua decorrência os indivíduos podem desenvolver cicatrizes de acne dentre elas a cicatriz atrófica que ocorre quando há perda de colágeno e a pele se apresenta com depressões. Atualmente a técnica de microagulhamento é utilizada para tratar cicatrizes de acne, através de um equipamento denominado roller que causa microrupturas na pele estimulando uma resposta inflamatória e reparadora que consequentemente atua na formação de novas fibras de colágeno e elastina, contribuindo na redução da cicatriz. O objetivo do estudo foi realizar um levantamento bibliográfico sobre o uso da técnica de microagulhamento em pacientes com cicatriz de acne atrófica. Trata-se de uma revisão integrativa de literatura. A coleta de dados foi realizada em janeiro e fevereiro de 2021, nas bases de dados Biblioteca virtual em saúde (BVS) pela Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), United States National Library of Medicine (PUBMED) e Physiotherapy Evidence Database (PEDRO), utilizando referências de 2017 a 2021.Os estudos mostram que a técnica de microagulhamento sendo aplicada de forma isolada possui benefícios para a diminuição das cicatrizes de acne, mas sendo aplicada em conjunto com o plasma rico em plaquetas e peeling, apresentam um melhor resultado. Conclui-se que o microagulhamento apresenta efeitos positivos para o tratamento de cicatrizes de acne, mas que sendo aplicado em conjunto com outras técnicas expressa um melhor resultado.
O papel da Telessaúde na pandemia da Covid-19: um relato de experiência da educação física no contexto hospitalar
Authors: Maduro Paula , Nathally Fernandes Souza Ammanda , Nunes Lopes Helder , Felipe Miyasato Lucas , Ribeiro dos Santos Márcia , Leonardo Gomes Costa Nathan , Silva de Brito Souzeni , Alcides Ramires Maduro Luiz
Published: December 2021

A Telessaúde se caracteriza como a oferta de serviços de atenção à saúde, em situações geográficas críticas ou em caso de situações excepcionais, como foi o caso da Covid-19. Desta forma foi utilizada a atividade física de maneira remota como estratégia de enfrentamento ao sedentarismo dos idosos, participantes do Projeto Saúde do Idoso do HU-Univasf, que tiveram que interromper as atividades desde o início da pandemia. Neste contexto, o objetivo deste relato de experiência é descrever a implantação da Telessaúde, no contexto hospitalar, como estratégia para ministrar aulas de atividades físicas aos idosos, durante o período da Covid-19. Participaram deste novo formato de aula remota 20 idosos, a profissional de educação física do HU-Univasf e cinco estudantes do colegiado de Educação Física da Universidade Federal do Vale do São Francisco (CEFIS-Univasf). O formato das aulas teve boa aceitação, apesar da barreira tecnológica existente na execução do projeto, visto que se verificou a aderência de 90% dos participantes selecionados, desde a implementação do modelo remoto. Foi constatado através de relatos, a melhora da capacidade física, da cognição e dos fatores psicológicos dos idosos. Bem como, a experiência aprimorou o processo pedagógico virtual da equipe de trabalho envolvida, se caracterizando como uma real possibilidade de adesão à prática de atividade física e proporcionando a melhora da qualidade de vida da população idosa.
Evaluation of homeopathic and biotherapic treatments in a swine farm to control Escherichia coli infection: a long term study
Authors: Coelho CidÃƒÆ’Ã‚Â©li de Paula , Soto Francisco Rafael , Vuaden Erlete Rosalina , Melville Priscilla Anne , Moreno Andrea Micke , Bonamin Leoni Villano , Benites Nilson Roberti
Published: December 2021

Background: Escherichia coli is the most important etiological agent in neonatal diarrhea in swine, and Enterotoxigenic Escherichia coli (ETEC) is the most commonly isolated. Regarding to virulence factors, five main types of fimbriae were already described in swine samples: F4 (K88), F5 (K99), F6 (987P), F18 and F41. Thermolabile (LT) and thermostable enterotoxins (ST), as well as shiga-like toxin or verotoxin (Stx2) are also found in isolates of swine origin, related to diarrhoea process.

Methods: This long term study has been developed in a swine farm (Mato Grosso, Brazil), in which 93 piglets were studied and 184 fecal samples were evaluated in two steps, with the aim to search the presence of Escherichia coli and to prepare a specific biotherapic medicine. Each step had one year of interval each other. Concurrently, for each step, a detailed anamnesis was made for choosing the ideal homeopathic medication for each step (Phosphorus 30 CH and Pulsatilla 30 CH, respectively). In each step, four groups consisting of 11-12 piglets and the respective primiparous mother pig were formed, and the treatments happened simultaneously: control group (antimicrobial treatment, the same used in the swine farm), homeopathic medication, E. coli biotherapic and homeopathic medication associated to biotherapic. The medications were made according to the Brazilian Homeopathic Pharmacopeia and the treatment lasted 12 days. After 24 days, in the weaning, the weight gain of each bath was also evaluated. Considering both steps, the research of virulence factors and enterotoxins was carried out in 99 Escherichia coli colonies through Polymerase Chain Reaction - PCR.

Results: In both steps, the homeopathy treated groups passed from 75.0% of diarrhea incidence to 8.3% at the end of the treatment (p
Oral, topical, and inhalation of Calcarea carbonica derivative complex (M8) to treat inflammatory mammary carcinoma in dogs
Authors: Da Silva Daniella Matos , Da Lozzo Eneida Janiscki , Buchi Dorly de Freitas , De Oliveira Carolina , GuÃƒÆ’Ã‚Â©rios Simone Domit
Published: December 2021

Background: Inflammatory mammary carcinoma (IMC) is locally aggressive, fast growing, highly malignant tumor that affects humans and dogs. Affected dogs usually are presented with generalized edema, pain, erythema, and skin ulceration in mammary glands. Surgery is not recommended and an effective treatment has not been established [1]. Calcarea carbonica derivative complex (M8) has demonstrated anticancer properties in a murine model, by improving innate immune response against tumor cells [2]. M8 is a complex high diluted medication comprised of Calcarea carbonica 16x, Aconitum napellus 20x, Arsenicum album 18x, Asa foetida 20x, Conium maculatum 17x, Ipecacuanha 13x, Phosphorus 20x, Rhus toxicodendron 17x, Silicea 20x, Sulphur 24x, and Thuya occidentalis 19x, dilution procedures have followed standard methodology described at the Brazilian Homeopathic Pharmacopoeia.

Aims: To describe different routes of M8 administration associated with oral pyroxican (non-steroidal anti-inflammatory drug) to treat dogs with IMC.

Methodology: Three female dogs with 10 years old median age were presented to the Veterinary Teaching Hospital at Federal University of Parana, Curitiba (HV-UFPR) with cytological and clinical diagnosis of IMC. Patients were treated with oral (0.5 mL,q12h), topical (q12h) and inhalatory (2 mL, q24h, through an ultrasonic inhalation device) M8, and oral pyroxican (0.3mg/kg, q24h).Thoracic radiographs showed pulmonary metastasis in all dogs.

Results: 7 days after initiating treatment all patients had clinical improvement. It was observed reduction on mammary glands inflammation and decreased pain sensitivity. One patient had 8 month of complete remission. The other two patients died 1 and 2 month after initial treatment. However none of the patients had pulmonary progressive disease, showed by radiographic examinations. Owners revealed treatment satisfaction in regards to quality of life improvement, easy M8 administration, good M8 palatability for dogs, and inflammation reduction.

Conclusion: The present report suggests that M8 influenced positively the anti -inflammatory treatment.

Keywords: Calcarea carbonica complex; inflammatory mammary carcinoma; routes of administration

References

[1] Sorenmo K. Canine mammary gland tumors. Veterinary Clinics of North America: Small Animal Practice. 2003 33(3):573-96.

[2] Oliveira CC, Abud APR, Oliveira SM, GuimarÃƒÆ’Ã‚Â£es FSF, Andrade LF, Di Bernardi RP, Coletto ELO, Kuczera D, Da Lozzo EJ, GonÃƒÆ’Ã‚Â§alves JP, Trindade ES, Buchi DF. Developments on drug discovery and on new therapeutics: highly diluted tinctures act as biological response modifiers. BMC Complementary and Alternative Medicine 2011, 11(101): 2-11.
Evaluation of immune response of BALB/c to homeopathic solutions
Authors: Siqueira Camila , Bonamin Leoni , Motta Priscila , Cardoso Thayná , Coelho Cideli , Couceiro JosÃƒÆ’Ã‚Â© Nelson , Holandino Carla
Published: December 2021

Introduction: Biotherapics are medicines prepared from etiologic agents, following Brazilian Homeopathic Pharmacopeia. Influenza is a disease that affects thousands of people worldwide every year, motivating the development of new therapies.

Aim: In this study, we developed two biotherapics from live/active influenza A virus, at 12x and 30x, and verified some immune response parameters in mice.

Methodology: The biotherapic was administered to male SPF 4 weeks old Balb/c mice. The protocol was approved by the UFRJ Ethics Committee of Animal Use (Protocol DFBCICB 040). Animals were stimulated daily, blindly, with different homeopathic medicines, at 1% (V/V) for a maximum period of 42 days. Three homeopathic medicines were tested: biotherapic 30x containing active influenza A virus; biotherapic 12x containing active influenza A virus; and thymulin 5cH. The experimental groups were: Group A (5 animals) ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ administration of thymulin 5cH, Group B (5 animals) ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ administration of biotherapic 30x, Group C (5 animals) ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ administration of biotherapic 12x, Group D (5 animals) - administration of a water 30x, Group E (5 animals) - administration of a water 12x, Group F (5 animals) - control (without treatment). After 21 days of treatment, all animals were challenged subcutaneously with the viral hemagglutinin antigen at the concentration of 7 ÃƒÂ¯Ã‚ÂÃ‚Â­g/200ÃƒÂ¯Ã‚ÂÃ‚Â­L and monitored by further 21 days. After euthanasia, all animals were autopsied and the spleen was collected for weight and immunehistochemistry analyses. Additionally, peritoneal washing was done and a ÃƒÂ¢Ã¢â€šÂ¬Ã…â€œpoolÃƒÂ¢Ã¢â€šÂ¬Ã‚Â of samples from each group was prepared to be analyzed by flow citometry.

Results: Mice treated with biotherapic 30x and thymulin 5cH showed similar profile, different from controls, in which a switch of lymphocytes/phagocytes proportion in the peritoneum was seen, followed by predominance of B1b cells in relation to conventional B and T cells (X2, p=0.005). Regarding to T cell population, in the contrary to control, CD4+ cells were predominant in relation to CD8+ cells (X2, p=0.0001). The immunehistochemistry revealed increase in the number of activated CD11b+ macrophages in spleen (p
Cellular Alterations Induced by Candida albicans RC Nosodes: an in vitro Study
Authors: Homsani Fortune , Moreno Gleyce , Siqueira Camila , Grechi Juliana , Santos AndrÃƒÆ’Ã‚Â© Luis , Holandino Carla
Published: December 2021

Introduction: Candidiasis is an opportunist infection, caused by yeast of the genus Candida, which emerges as one of the main causes of systemic infections in hospitalized patients. Candida albicans is the most common causing agent of these infections. According to the Brazilian Homeopathic Pharmacopeia[1], nosodes are medicines compounded from chemically undefined biological products. Living nosodes are prepared using the etiologic agent of an illness in its infective form, were first developed by Brazilian physician Roberto Costa (RC). Roberto CostaÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s research indicated that living nosodes present a higher capability to stimulate the hostÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s immunological system [2].

Aim: This study aims to evaluate cellular alterations induced in C. albicans yeasts and RAW 264-7 macrophages by Candida albicans RC.

Methodology: To prepare Candida albicans RC, one part of C. albicans infective yeast suspension (108 cell/ml) was diluted in 9 parts of sterile distilled water and submitted to 100 mechanical succussions. This process was successively repeated to the potencies of 12x and 30x1. Water 30x was prepared by the same technique, as control. The cell viability of C. albicans previously treated with nosodes in both potencies and respective controls was evaluated using the samples at the concentration of 10% (V/V), in a volume of 1ml, distributed in 1-3 days. The viability of the yeast cells was analyzed by MTT (3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolic) (5mg/ml) assay [3] and by Propidium Iodide (PI) incorporation methods. Additionally, using macrophages RAW 264-7 as a cell model, Nitric Oxide (NO) production and cell viability were also evaluated. For this, the following protocol of cell treatment was employed: on each experimental day, RAW 264-7 cells were treated 4 times (4 stimuli) with RC nosode 30x at the concentration of 10% (V/V).

Results: The nosodes (12x and 30x) did not present cytotoxic effects on macrophage cells (n=1), or on C. albicans yeasts (n=2), as detected by MTT and PI methods. Moreover, no statistically significant differences on NO production were detected among the experimental groups (n=6).

Conclusion: Preliminary results of in vitro assays indicate that nosodes (12x and 30x) do not alter mitochondrial activity or cell viability of C. albicans. Similarly, treatment by RC nosodes does not seem to alter NO release and mitochondrial activity of RAW macrophages. New experiments are being performed to confirm these preliminary data.
Experimental induced wound cicatrisation after highly diluted products treatment
Authors: Jeronimo Fernando Fortunato , GonÃƒÆ’Ã‚Â§alves Jenifer Pendiuk , Do Nascimento Katia Fialho , De Oliveira Simone Martins , De Oliveira Carolina Camargo , Farias ÃƒÆ’Ã¢â‚¬Â°dison Luiz Prisco , Buchi Dorly de Freitas
Published: December 2021

Introduction: Skin is an attractive target to study extracellular matrix, due to abundance in Connective tissue. In cases of injuries the first step is an inflammatory reaction and subsequent the healing that involves several changes in the matrix. These changes are fundamental to inflammatory cells activities allowing healing. Highly diluted products were shown to facilitate inflammatory mediators and to activate immune cells in vivo and in vitro, thus it can be effective to wound healing.

Aims: This study aims to evaluate highly diluted products effects on inflammation and cicatrization process.

Methodology: Three compounds (M8 (Aconitum napellus 20dH, Arsenicum album 18dH, Asa foetida 20dH, Calcarea carbonica 16dH, Conium maculatum 17dH, Ipecacuanha 13dH, Phosphorus 20dH, Rhus toxicodendron 17dH, Silicea 20dH, Sulphur 24dH, Thuja occidentalis 19dH), M1 (Chelidonium majus 20dH, Cinnamon 20dH, Echinaceae purpurea 20dH, Gelsemium sempervirens 20dH plus all M8 compounds) and Curcuma cH30 ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ simple product), were manipulated as a gel and applied on mice dorsal flank after incision and suture (approximately 1 cm and three points), for 3 consecutive days. After the treatments the scars were evaluated macroscopically, the animals were killed, the skin samples collected, fixed and processed for Hematoxilin-Eosin (HE) and Masson Tricromic (to observe the collagen fibers type I). The slices were analyzed and images collected by a light microscope Olympus BX51 with camera attached Olympus DP72.

Results: It was observed a higher and faster rate of tissue epithelization in the treated groups after three days of gel-product application. This could be observed in lower rates in the control group (no treatment) - Figure 1 and 2). Regeneration and organization of connective tissue were proportional to epithelization the treated groups. We also observed evidences of changes in amount of neutrophils and fibroblasts, resulting in changes in the healing period. Analyses for these confirmations are in progress.
Evaluation of biological activities of highly diluted nucleotide sequences by using cellular models
Authors: Capieaux Etienne , Alsaleh Ghada , Borde ChloÃƒÆ’Ã‚Â© , Wachsmann Dominique , MarÃƒÆ’Ã‚Â©chal Vincent , Dorfman Pierre
Published: December 2021

Background: highly diluted specific nucleic acids (SNAÃƒâ€šÃ‚Â®), designed to modulate viral and cytokine genes expression, are currently used in Micro-Immunotherapy to treat viral infections and immune disorders. Although some preliminary studies have showed clinical benefit of these homeopathic preparations [1], no experimental data are available to explain their mechanism of action.

Aims: to investigate the in vitro effect of two sets of highly diluted (HD) SNA targeting i) latent/lytic Epstein-Barr virus (SNA EBV) and ii) TNF-ÃƒÅ½Ã‚Â± and its receptor p55 involved in rheumatoid arthritis (SNA RA) on cellular models.

Methodology: serial homeopathic dilutions of SNA EBV and SNA RA (15cH-18cH) were tested on a EBV-positive B-lymphoblastoid (B95-8) and on a LPS-stimulated macrophage (THP1) cell lines respectively, in comparison with agitated/diluted water and scramble DNA sequences prepared in the same conditions (negative controls). For B95-8 proliferative model, high mobility group box 1 protein (HMGB1) was used as reference. Analyzed biological parameters on B95-8 were i) cell proliferation measured after 24 and 48h of incubation with HD SNA and ii) expression of the EBV ZEBRA protein in response to TGF-ÃƒÅ½Ã‚Â² by Western-blotting (T+24h). For THP1 model, TNF-ÃƒÅ½Ã‚Â± synthesis and release were determined by RT-qPCR and ELISA (protein), after stimulation by LPS (1Ãƒâ€šÃ‚Âµg/ml) and HD SNA co-administration.

Results: we demonstrated that HD SNA RA significantly down-regulated TNF-ÃƒÅ½Ã‚Â± synthesis and release. This biological activity was showed to be specific (no effect of HD scramble SNA) and related to the level of dilution (maximal effect with higher dilutions). Unexpectedly, a biological effect of agitated/diluted water was also detected in both cellular models. For B95-8 model, this effect resulted in a significant decrease of B95-8 proliferation (comparable to the HMGB1 reference) and an inhibition of ZEBRA expression. Similarly, a reproducible stimulation effect of HD water was obtained in the LPS-stimulated THP1 model.

Conclusions: these findings indicate that highly diluted SNA RA can regulate TNF-ÃƒÅ½Ã‚Â± synthesis and release by LPS-stimulated THP1 and support the hypothesis that these homeopathic preparations may act in modulating mRNA expression of the targeted genes. This in vitro work underlines the potential effect of agitated water in context of cellular models for testing biological properties of HD.

[1] Jenaer M, Henry MF, Garcia A, Marichal B. Evaluation of 2LHERP in preventing recurrences of genital herpes. Br Homeopath J. 2000 Oct;89(4):174-7.
The ice–vapour interface during growth and sublimation
Authors: Cascajo-Castresana Maria , Morin Sylvie , Bittner Alexander M.
Published: December 2021

Abstract. We employed environmental scanning electron microscopy
(ESEM) in low-humidity atmosphere to study the ice growth, coalescence of
crystallites, polycrystalline film morphology, and sublimation, in the
temperature range of −10 to −20 ∘C.
First, individual ice crystals grow in the shape of micron-sized hexagonal
columns with stable basal faces. Their coalescence during further growth
results in substantial surface defects and forms thick polycrystalline
films, consisting of large grains separated by grain boundaries. The latter
are composed of 1 to 3 µm wide pores, which are attributed to the
coalescence of defective crystallite surfaces. Sublimation of isolated
crystals and of films is defect-driven, and grain boundaries play a decisive
role. A scallop-like concave structure forms, limited by sharp ridges, which
are terminated by nanoscale asperities. The motivation for this work is also
to evaluate ESEM's ability to provide a clean and reproducible environment
for future study of nucleation and growth on atmospherically relevant
nucleators such as materials of biological origin and inorganic materials.
Hence, extensive information regarding potential ESEM beam damage and effect
of impurities are discussed.
Balloon borne aerosol-cloud interaction studies (BACIS): New observational techniques to understand and quantify aerosol effects on clouds
Authors: Ravi Kiran Varaha , Venkat Ratnam Madineni , Fujiwara Masatomo , Russchenberg Herman , Wienhold Frank G. , Madhavan Bomidi Lakshmi , Roja Raman Mekalathur , Renju Nandan , Akhil Raj Sivan Thankamani , Hemanth Kumar Alladi , Ravindra Babu Saginela
Published: December 2021

Abstract. Better understanding of aerosol-cloud interaction processes is an important aspect to quantify the role of clouds and aerosols in the climate system. There have been significant efforts to explain the ways aerosols modulate cloud properties. However, from the observational point of view, it is indeed challenging to observe and/or verify some of these processes because no single instrument or platform is proven sufficient. With this motivation, a unique set of observational field campaigns named Balloon borne Aerosol Cloud Interaction Studies (BACIS) is proposed and conducted using balloon borne in-situ measurements in addition to the ground-based (Lidars, MST radar, LAWP, MWR, Ceilometer) and space borne (CALIPSO) remote sensing instruments from Gadanki (13.45° N, 79.2° E). So far, 15 campaigns have been conducted as a part of BACIS campaigns from 2017 to 2020. This paper presents the concept of observational approach, lists the major objectives of the campaigns, describes the instruments deployed, and discusses results from selected campaigns. Consistency in balloon borne measurements is assessed using the data from simultaneous observations of ground-based, space borne remote sensing instruments. A good agreement is found among multi-instrumental observations. Balloon borne in-situ profiling is found to complement the information provided by ground-based and/or space borne measurements. A combination of the Compact Optical Backscatter AerosoL Detector (COBALD) and Cloud Particle Sensor (CPS) sonde is employed for the first time to discriminate cloud and aerosol in an in-situ profile. A threshold value of COBALD color index (CI) for ice clouds is found to be between 18 and 20 and CI values for coarse mode aerosol particle range between 11 and 15. Using the data from balloon measurements, the relationship between cloud and aerosol is quantified for the liquid clouds. A statistically significant slope (aerosol-cloud interaction index) of 0.77 (0.86) found between aerosol back scatter from 300 m (400 m) below the cloud base and cloud particle count within the cloud indicates the role of aerosol in the cloud activation process. In a nutshell, the results presented here demonstrate the observational approach to quantify aerosol-cloud interactions and paves the way for further investigations using the approach.
Hydroclimatic variability of opposing Late Pleistocene climates in the Levant revealed by deep Dead Sea sediments
Authors: Ben Dor Yoav , Marra Francesco , Armon Moshe , Enzel Yehouda , Brauer Achim , Schwab Markus Julius , Morin Efrat
Published: December 2021

Abstract. Annual and decadal-scale hydroclimatic variability
describes key characteristics that are embedded into climate in situ and is
of prime importance in subtropical regions. The study of
hydroclimatic variability is therefore crucial to understand its
manifestation and implications for climate derivatives such as hydrological
phenomena and water availability. However, the study of this variability
from modern records is limited due to their relatively short span, whereas
model simulations relying on modern dynamics could misrepresent some of its
aspects. Here we study annual to decadal hydroclimatic variability in the
Levant using two sedimentary sections covering ∼ 700 years
each, from the depocenter of the Dead Sea, which has been continuously
recording environmental conditions since the Pleistocene. We focus on two
series of annually deposited laminated intervals (i.e., varves) that
represent two episodes of opposing mean climates, deposited during MIS2
lake-level rise and fall at ∼ 27 and 18 ka,
respectively. These two series comprise alternations of authigenic aragonite
that precipitated during summer and flood-borne detrital laminae deposited
by winter floods. Within this record, aragonite laminae form a proxy of
annual inflow and the extent of epilimnion dilution, whereas detrital
laminae are comprised of sub-laminae deposited by individual flooding
events. The two series depict distinct characteristics with increased mean
and variance of annual inflow and flood frequency during “wetter”, with
respect to the relatively “dryer”, conditions, reflected by opposite
lake-level changes. In addition, decades of intense flood frequency
(clusters) are identified, reflecting the in situ impact of shifting
centennial-scale climate regimes, which are particularly pronounced during
wetter conditions. The combined application of multiple time series analyses
suggests that the studied episodes are characterized by weak and
non-significant cyclical components of sub-decadal frequencies. The
interpretation of these observations using modern synoptic-scale
hydroclimatology suggests that Pleistocene climate changes resulted in
shifts in the dominance of the key synoptic systems that govern rainfall,
annual inflow and flood frequency in the eastern Mediterranean Sea over
centennial timescales.
How to perform global sensitivity analysis of a catchment-scale, distributed pesticide transfer model? Application to the PESHMELBA model
Authors: Rouzies Emilie , Lauvernet Claire , Sudret Bruno , Vidard Arthur
Published: December 2021

Abstract. Pesticide transfers in agricultural catchments are responsible for diffuse but major risks to water quality. Spatialized pesticide transfer models are useful tools to assess the impact of the structure of the landscape on water quality. Before considering using these tools in operational contexts, quantifying their uncertainties is a preliminary necessary step. In this study, we explored how global sensitivity analysis can be applied to the recent PESHMELBA pesticide transfer model to quantify uncertainties on transfer simulations. We set up a virtual catchment based on a real one and we compared different approaches for sensitivity analysis that could handle the specificities of the model: high number of input parameters, limited size of sample due to computational cost and spatialized output. We compared Sobol' indices obtained from Polynomial Chaos Expansion, HSIC dependence measures and feature importance measures obtained from Random Forest surrogate model. Results showed the consistency of the different methods and they highlighted the relevance of Sobol' indices to capture interactions between parameters. Sensitivity indices were first computed for each landscape element (site sensitivity indices). Second, we proposed to aggregate them at the hillslope and the catchment scale in order to get a summary of the model sensitivity and a valuable insight into the model hydrodynamical behaviour. The methodology proposed in this paper may be extended to other modular and distributed hydrological models as there has been a growing interest in these methods in recent years.
HAYVANSAL KAYNAKLI PROTEİN TAKVİYELERİ VE HELAL GIDA AÇISINDAN DEĞERLENDİRİLMESİ
Authors: TANYILDIZ Sena Nur , YILDIRIM Hatice , YAMAN Mustafa
Published: December 2021

Proteinler günlük beslenme örüntüsü içerisinde yer alan temel besinlerden birisidir. Bireylerin günlük protein gereksinimi ise çok çeşitli değişkenlerle ilişkilidir. Örneğin, sporcularda protein gereksinimi yüksektir. Sporcu veya normal bireylerdeki bu gereksinimin karşılanması için günlük beslenmeye ek olarak bazı protein supplementleri/besin takviyeleri de kullanılabilmektedir. Bu supplementler; hayvansal, bitkisel ya da mikrobiyal kaynaklı olabilmektedir. Bunların arasında da hayvansal kaynaklı kolajen ve türevleri ayrı bir öneme sahiptir. Genel olarak bireylerin protein supplementlerini tercih sebepleri farklı olabilmekte ve tüketiciler, burada birçok faktörden etkilenmektedirler. Özellikle, dini inançlar bu açıdan en önemli faktörler arasında sayılmakta ve özellikle gıda veya supplement seçimi ve/veya tüketimini doğrudan etkilemektedir. Diğer inançlarda olduğu gibi İslam dininde de gıda maddesi seçimini etkileyen temel esaslar bulunmakta ve burada da helal ya da haram kavramları belirleyici olmaktadır. Bu derleme çalışmasında, hayvansal kaynaklı protein supplementleri/besin takviyeleri ile bunların helallik açısından değerlendirilmesi amaçlanmıştır.
Catholic churches and ministry in Malbork in the years
1525–1772
Authors: Kopiczko Andrzej
Published: December 2021

The article presents the history of the Catholic churches, operating in Malbork in the early modern
period. Most attention was paid to the parish St. John the Evangelist, which – with short breaks in the second half of the sixteenth century and during the First Swedish-Polish War – remained in the hands of Catholics.
With post-visit protocols learn about repairs carried out, the order of worship and involvement of the clergy.
On the basis of the preserved since 1700 year vital records we can conclude that each year about 200 children
was baptized and was contained from 50 to 150 weddings. Since the second half of the eighteenth century
there are also records of marriages concluded by Lutherans in the Catholic Church, even when both spouses
were not Catholics.Apart from the parish of St. John the Evangelist churches still functioning: the castle of the
Blessed Virgin Mary, St. Lawrence and the hospital of the Holy Spirit and Chapels.A major role in the pastoral
care in the modern era played the Jesuits, who have taken the ministry in 1618.
Social land classification in Warmia and Mazury region in 1949 and its consequences
Authors: Gross Radosław
Published: December 2021

Social land classification conducted in 1949 quite significantly affected the location of farms in the
Stalinist period. Authorities, by means of deliberate action, by dishonestly overstating the classes of land,
artificially overestimated the encumbrances of individual farms. The scale of anomalies was large and the cost
of benefits imposed on peasants in many cases turned out to be unbearable. Particularly strongly affected by
the consequences of unfair land classification were the owners of individual farms in Warmia and Mazury,
sparsely populated area, devoid of equipment and inventory, where after the war a specific surface structure of
farms developed, in which medium and large areas dominated. Due to overstated classes of agricultural land
and applied system of progression in benefits, maintaining farms became unprofitable, and therefore many
of them collapsed. The new agricultural policy implemented since 1948, in which the so-called social land
classification became a component, deepened the problems of Olsztyn agriculture.
„Þæt is mid Estum þeaw þæt þærsceal ælces geðeodes man beon forbærned”.
What exactly Wulfstan said about the burning of the dead by Ester in the
fragment of his report on the trip to Truso? .
Authors: Panfil Rafał
Published: December 2021

In 1961 a part of Old English Orosius, the description of northernmost and central Europe, was
translated into Polish and edited by Gerard Labuda. The source contains two short travel accounts by Othere
and Wulfstan in the end of ninth century. The Polish editor did not avoid a number of linguistic mistakes
made during the translation. Moreover, this was issued without any syntactic and grammatical analysis of the
original Old English text. The Labuda’s edition only provides the Polish translation of the modern English
translation by the mid-nineteenth century English scholar Joseph Bosworth. This resulted in the wrong inter�pretation of some important information contained in it.
The subject of this paper is a one of the sentences included in the final fragment of the description of
the funeral rites among the Ests/the Old Prussians – „Þæt is mid Estum þeaw þæt þær sceal ælces geðeodes
man beon forbærned”.
My aim is to understand this passage of the OE text correctly by providing it’s linguistic and grammati�cal examination to see how it corresponds with the known or presumed historical circumstances of the time
and place. The interpretation of the old written source cannot be separated from its context, it this particular
case especially from the local archaeological context. This will be arguing in my paper.
At last,the above mentioned passage should be translated as:„And that is a custom among the Ests that
people of every nationality must be cremated there”. According to this custom, the dead body of every man,
that has passed away in the Witland, must be burned on the funeral pile. This Wulfstan’s description seems to
be strongly supported by the number of rich equipped graves of the foreigners discovered and archaeologi�cally investigated at the number of early medieval cemeteries located in modern day city of Elbląg area and
dated to the VIII/IX/X/XI century.
Citizens of Warmia in the light of the visits of Bishop Krzysztof Andrzej Szembek
Authors: Achremczyk Stanisław
Published: December 2021

Dominion Warmia during the reign of bishopChristopher Szembeka wasinhabited by about 90 000 people.
Most of them were peasant population, less than 25% were burghers a small fraction of Warmian nobility. This
article shows how the state of the diocese presented in the light of the visits of churches, performed in the
difficult times of after the Great Northern War. Visits general bishop Krzysztof Szembek Warmians appeared
as decent Catholics attending church services generally abiding by the Ten Commandments. Of course, the
bishop had commented on the maintenance of churches, farmhouses and rectory but generally the picture
draws a positive.
Between Ryn and Szestno. Was the Teutonic Order’s commandery
established in Szestno?
Authors: Białuński Grzegorz
Published: December 2021

W żadnych dotychczasowych wykazów komturstw krzyżackich komturia w Szestnie nie pojawia
się. Istnieją jednak pewne wzmianki źródłowe, które zmuszają do zadania zawartego
w tytule pytania. Chodzi mianowicie o repertorium dokumentów dotyczących okręgów szestneńskiego
i leckiego (giżyckiego) na początku XVI w.: Sehesten und Letzen. Extraordinarie
[1503–1523]. Co prawda zawiera ono jedynie ich regesty, ale na ogół kopie owych dokumentów
zachowały się w zespole Ordensbriefarchiv. I tak już na samym początku tego rejestru wzmiankowany
został Hauskomptur zu Sehesten. Niestety regest, jak też zachowana kopia, nie jest
datowany. Nieco dalej znajdujemy kolejne dwa regesty dokumentów wystawionych w 1516 r.,
w tym jeden przez komtura szestneńskiego (Compthur von Sehesten), drugi zaś zawierający jego
relację (Comptur zu Sehesten). W zespole Ordensbriefarchiv zachował się też inny dokument,
w którym wzmiankowano komtura w Szestnie. Wreszcie ostatni znany nam dokument z wiadomością
o komturze w Szestnie pochodzi z zespołu Pergamenturkunden. O pomyłce pisarzy lub
kopistów nie może być mowy, a wcześniej i później znajdujemy inne wzmianki o urzędnikach
szestneńskich – prokuratorach (Pfleger) i namiestniku (Stathalter).
About begginning of the castle in Olsztyn
Authors: Białuński Grzegorz
Published: December 2021

Analiza przeprowadzona w artykule pozwala odrzucić pogląd najnowszej literatury na temat
genezy Olsztyna (J. Sikorski, S. Achremczyk) i częściowo powrócić do ustaleń wcześniejszej
historiografii (H. Bonk, A. Funk, A. Wakar). Stwierdzono zatem, że najprawdopodobniej
w 1334 r., zgodnie z XVIII wieczną tradycją, powstała ziemno-drewniana strażnica, jakkolwiek
nie w Olsztynie, tylko w pobliżu Jeziora Bartąg (na wzniesieniu między Bartągiem a Bartążkiem)
lub na wschodnim brzegu Jeziora Kielarskiego. Kwestia lokalizacji na podstawie źródeł
pisanych jest niemożliwa do rozstrzygnięcia, więc postuluje się jak najszybsze zbadanie archeologiczne,
tym bardziej, że obiekt Bartąg nad jeziorem jest zagrożony zabudową mieszkaniową.
Strażnica otrzymała nazwę całej ziemi Berting (en). W 1348 r. kapituła postanowiła wybudować
miasto a wraz z nim nowy, kamienny zamek. Wybrali zakole Łyny na obszarze dzisiejszego
Olsztyna. Stara twierdza funkcjonowała tylko do czasu budowy nowego zamku. Z czasem
nazwa tego obiektu została zapomniana (zachowała się w nazwie sąsiedniej wsi Bartąg i Bartążek).
Pamiętano, że teren ten był siedzibą „starego komornictwa”. Przez nieokreślony czas,
nowa nazwa, nawiązująca do pamięci o starym zamku, a także nazwa nowego zamku, stąd Stary
Olsztyn. O trwałości nazwy świadczy początek XIX wieku, kiedy posiadłość wiejską powstałą
na miejscu dawnej leśniczówki nazwano Stary Olsztyn.