bluuebunny/crossref_metadata_2025 huggingface dataset:
Study Planning of Check Dam Using Waste Tires at Sumbersari UB Forest Area
Authors: Runi Asmaranto  , Melvin Al Ishar  , Anggara Wiyono Wit Saputra
Published: February 2025

A check dam is a construction solution to overcome various catchment area challenges, especially erosion and sedimentation control in the upstream region. The strategic implementation of this plan includes various methodologies such as topographic, geotechnical identification, hydrological analysis, sedimentation analysis, material specification, hydraulic analysis, stability analysis, storage capacity analysis, and budget plan development. The purpose of this research is to check dam planning using waste tires which includes sediment discharge, detailed dimensions of the building, and building safety, to the required cost budget plan by reviewing the aspects of environmentally friendly, low cost, and waste utilization by sustainable development goals. The type of sediment flow that occurs is debris flow with a sediment discharge rate of 25,939 m3/s, due to the flood discharge phenomenon with a significant 25-year return period is 10,580 m3/s. The safety number of the proposed check dam design using the calculation of forces acting and Plaxis 2D V20 software has exceeded the safety permit requirements with various conditions that may occur at the study site. In a single flood, this check dam can effectively mitigate for approximately 4 days. To implement this development plan, an estimated budget of IDR773.472.940 has been projected.
Risk Analysis of Occupational Safety and Health (K3) Using the HIRADC Method on Chiller Replacement Works: A Case Study
Authors: Prastowo Toni Yuri , Rahmadika Luthfi Manaf Imsarif  , Dedy Sanjaya  , Nana Taryana
Published: February 2025

Occupational safety and health (K3) is an important aspect that must be considered in construction projects to prevent work accidents. This study aims to analyze potential risks and determine control measures using the Hazard Identification Risk Assessment and Determining Control (HIRADC) method on a chiller replacement work at a hotel renovation project in Jakarta, Indonesia. Potential hazards were identified through direct observation, worker interviews, and document review. Risk assessment was carried out by calculating the likelihood and severity scores to determine risk levels. Several control measures were implemented based on the risk hierarchy. A risk comparison before and after implementing controls showed a reduction in risk levels. Structural analysis using ETABS proved that the temporary reinforcement provided structural safety. The estimated cost of Rp. 250,456,350 met K3 budget provisions. This study demonstrates that risk analysis using HIRADC is effective in reducing risks and ensuring K3 aspects in construction works.
Desain Modul Penyesuaian Arus Listrik dan Switching Berbasis Remote Control
Authors: Tholib Hariono  , Syifa' Ahmad Syifa' Ul Qulub
Published: February 2025

Perkembangan ilmu pengetahuan dan teknologi yang pesat telah mempermudah kehidupan manusia, memerlukan sumber daya manusia yang mampu mengoptimalkan teknologi tersebut. Kemajuan teknologi telah mendorong terciptanya alat-alat yang mempermudah pekerjaan manusia menjadi lebih efisien dan praktis, termasuk dalam pengendalian alat elektronik. Namun, pengendalian alat elektronik seperti lampu dan kipas angin masih banyak dilakukan secara manual menggunakan saklar, yang kurang sesuai dengan kebutuhan zaman modern dan memiliki beberapa kelemahan, seperti ketidakmampuan mengendalikan dari jarak jauh. Penelitian ini bertujuan merancang dan mengimplementasikan modul penyesuai arus listrik dan switching berbasis remote control yang dapat mengontrol alat elektronik seperti lampu LED dan kipas angin secara lebih interaktif dan efisien. Modul ini dirancang menggunakan arduino untuk memberikan kontrol terhadap arus listrik dan perangkat elektronik secara nirkabel, meningkatkan kemudahan dan kenyamanan pengguna serta berkontribusi pada penghematan energi. Metode yang digunakan dalam penelitian ini adalah metode prototype, yang melibatkan komunikasi kebutuhan pengguna, perencanaan cepat, pemodelan perancangan, pembentukan prototipe, dan pengujian sistem untuk evaluasi. Pengumpulan data dilakukan melalui observasi dan studi pustaka, dengan data primer dan sekunder sebagai sumber informasi. Pengujian alat dilakukan untuk memastikan fungsi alat beroperasi sesuai spesifikasi, dengan hasil menunjukkan bahwa modul berhasil dalam memutus dan menyambungkan tegangan listrik, mengatur timer, menaikkan dan menurunkan tegangan listrik, serta mengontrol jarak operasi remote hingga 3-4 meter. Secara keseluruhan, modul ini terbukti andal dan efektif dalam menjalankan semua fungsi yang dirancang, memberikan kontribusi signifikan dalam menciptakan gaya hidup modern yang nyaman, efisien, dan terkendali.
Analisis Perhitungan Daya Motor Dan Kecepatan Aliran Pada Wind Tunnel Tipe Open Circuit Dengan Test Section Area 0,4 X 0,4 m2
Authors: Mufidurroyhan Ziyan , Subagyo
Published: February 2025

Wind tunnel (terowongan angin) yaitu peralatan uji berstruktur tabung dimana udara dipaksa melaju dengan kencang yang digunakan untuk mempelajari efek aliran aerodinamis pada suatu objek benda. Benda atau objek yang diuji ditempatkankan dibagian tengah test section. Maka udara direaksikan melewati objek benda dengan sebuah skema fan. Fan sangat penting pada pengujian aerodinamis suatu objek benda, sebab aliran yang stabil dan bagus sangat berpengaruh dalam pengujian wind tunnel. Selain pengaruh pada konstruksi wind tunnel, fan dan motor juga ikut berperan penting guna memperoleh aliran flow yang stabil untuk digunakan dalam pengujian. Penelitian ini bertujuan untuk mengetahui nilai CMH (Cubic Meter\Hour) yang dihasilkan dari fan, untuk mengetahui nilai keseluruhan jumlah kerugian energi pada tiap komponen wind tunnel, dan untuk mengetahui daya motor yang akan digunakan pada fan. Dari perhitungan yang telah dilakukan, maka nilai minimal air volume yang diperlukan pada bagian test section adalah sebesar 12.096.608,2 m3/h (Cubic Meter Hour). Perhitungan energy losses dari setiap komponen pada wind tunnel tipe open circuit yaitu : K0  = Honeycomb = 6,07523304, K1  = Screen = 6,07523304, K2 = Contraction = 5,9392, K3 = Test Section = 40, K4 = Diffuser = 39,364, K5 = Saluran discharge = 19,4907322, Maka total dari keseluruhan nilai tersebut dijumlahkan  Ktotal = 116,944398, dan perhitungan nilai daya motor yang dibutuhkan sebesar 101.713,4 Watt.
Desain, Simulasi dan Evaluasi Biaya Pembangkit Listrik Tenaga Surya 5 MW di Universitas Tadulako menggunakan Pvsyst
Authors: Irwan Mahmudi  , Sholihah Ratih mar'atus , Nurahani Amin  , Oktadli Pratama Simbaju
Published: February 2025

Energi matahari (solar) memberikan banyak manfaat bagi kehidupan manusia. Salah satu pemanfaatan energi surya yang dapat diimplementasikan adalah dalam bentuk Pembangkit Listrik Tenaga Surya (PLTS). Universitas Tadulako berkomitmen untuk melaksanakan PLTS secara mandiri. Salah satu upaya yang dilakukan adalah dengan memanfaatkan lahan yang luas sebagai lahan PLTS yang saling terhubung, yang sering disebut dengan PLTS on-grid atau grid-connected. PLTS on-grid merupakan sistem PLTS yang terhubung dengan jaringan distribusi PLN. Pada sistem ini, jaringan listrik PLN berperan sebagai penyalur atau penyambung arus listrik yang berasal dari panel surya yang disalurkan ke beban. Dari hasil pengukuran diketahui luas lahan kosong Universitas Tadulako menurut masterplan UNTAD sekitar 5 hektar. Melalui software PVSyst total daya yang dihasilkan oleh PV sebesar 5544 kWp dan total daya inverter sebesar 4620 kWac dengan total PV terpasang sebanyak 10080 panel. Panel tersebut terhubung dengan 42 inverter. Setiap satu unit inverter mempunyai 12 string dan setiap string pada inverter terdiri dari 20 panel surya. Dari hasil tersebut, investasi sistem PLTS di Universitas Tadulako diperkirakan mencapai Rp. 75.907.251.114,00.
ANALISIS SISTEM PENYEDIAAN AIR BERSIH KAMPUNG KASAI KECAMATAN PULAU DERAWAN KABUPATEN BERAU
Authors: Anang Wahananto  , Budi Witjaksana  , Andi Patriadi
Published: February 2025

Kampung Kasai merupakan kampung nelayan yang terus berkembang dari kampung tertinggal menuju kampung berkembang. Seiring dengan pertumbuhan itu tuntutan kebutuhan prasarana dan sarana air bersih terus meningkat. Kebutuhan air bersih mencapai puncaknya pada saat musim kemarau tiba yang menyebabkan tekanan besar pada pasokan air bersih yang berakibat ketidakcukupan untuk kebutuhan sehari-hari masyarakat. Perlu dilakukan analisis mendalam mengenai strategi pengelolaan sumber air bersih yang efektif untuk mengatasi kekurangan pasokan pada musim kemara. Metode penelitian menggunakan Analisis proyeksi jumlah penduduk dan Pengukuran Debit pada Sumur Pengambilan.  Dilakukan uji pumping test di lokasi sumur setelah sebelumnya dilakukan pengistirahatan selama ±24 jam kepada sumur bor yang akan di uji pemompaan. Dari uji pumping test selama 24 jam nonstop didapatkan debit konstan sebesar 2 liter/dt. Uji Pemompaan dilaksanakan pada tanggal 5 Maret 2024 sampai 11 Maret 2024 dengan metode constant rate test menggunakan pompa yang tersedia di lokasi pengujian. Uji pemompaan dilakukan secara terus menerus selama waktu tertentu dan kedudukan muka air tanah mengalami kondisi relatif stabil pada kedalaman tertentu, kemudian pompa dimatikan. Adapun dari uji pumping test selama 24 jam nonstop didapatkan debit konstan sebesar 2,32 Lt/detik. Sehingga disimpulkan bahwa uji pemompaan lebih besar dari perhitungan potensi air tanah.
APLIKASI EDUKASI PENGENALAN DAN PENGASAH DAYA INGAT RAGAM AKSARA
Authors: Siti Alvi Nikmah  , Patmi Kasih  , Ardi Sanjaya
Published: February 2025

Sistem pembelajaran aksara daerah khususnya aksara Jawa pada tingkat sekolah dasar masih konvensional menggunakan media buku teks dan papan tulis. Pengajaran dan pelafalan dilakukan secara langsung oleh guru dan diikuti oleh siswa. Pembelajaran konvesional memiliki beberapa kekurangan yaitu sebagian siswa merasa bosan dalam proses pembelajaran yang monoton dan kurang menarik sehingga menyebabkan siswa sulit untuk memahami dan menghafal aksara daerah. Solusi yang diusulkan untuk mengatasi permasalahan tersebut yaitu model pembelajaran dapat dikemas menjadi lebih interaktif dan inovatif dengan pembelajaran berbasis digital seperti aplikasi edukasi yang didalamnya terdapat teknologi Augmented Reality yang menampilkan objek 3D. Kemudian Matching Card permainan pencocokan gambar aksara untuk membantu penghafalan huruf aksara. Proses perancangan aplikasi menggunakan metode waterfall karena metode ini dikerjakan secara berurutan sesuai dengan tahapannya. Untuk metode penelitian menggunakan Marker Based Tracking digunakan untuk teknologi Augmented Reality dan algoritma Shuffle Random digunakan untuk pengacakan gambar pada Matching Card. Hasil dari penelitian ini adalah aplikasi edukasi yang berisi aksara daerah yaitu Jawa, Lampung, dan Sunda yang bertujuan untuk membantu pembelajaran aksara daerah sekaligus mengenalkan keanekaragaman aksara daerah di Indonesia. Dan dapat disimpulkan bahwa aplikasi ini sudah sesuai untuk dijadikan media bantu pembelajaran dengan hasil presentase penilaian 89% dari koresponden sebagai pengguna aplikasi edukasi ini.
Information System Strategy for Improving Academic Service Quality at UM Banjarmasin Through the Development of Academic Extension (ADEX) Innovation Application
Authors: Kamarudin Kamarudin
Published: February 2025

This research program aims to enhance academic service quality at Universitas Muhammadiyah Banjarmasin (UM Banjarmasin) through the development of an innovative application called Academic Extension (ADEX). The initiative was driven by the need to improve efficiency and integration of academic services, addressing the current inadequate systems that fail to support effective academic management. The research methodology involved three key phases: needs analysis, application development, and field testing. ADEX incorporates various features to streamline academic management, including schedule management, attendance tracking, and communication channels between faculty members and students. The implementation of ADEX has demonstrated significant improvements in both efficiency and quality of academic services at UM Banjarmasin, delivering tangible benefits to the entire academic community. Results indicate that the integration of ADEX has successfully addressed the initial challenges, providing a comprehensive solution for academic service management while enhancing the overall educational experience for both faculty and students.
Analisis Sentimen Masyarakat Terhadap Kebijakan Kenaikan Umk 6,5% Menggunakan Metode Naive Bayes
Authors: Fitriyadi Farid , Astikasari Arsaela
Published: February 2025

Kenaikan Upah Minimum Kabupaten/Kota (UMK) sebesar 6,5% telah memicu beragam tanggapan pro dan kontra dari masyarakat di semua sektor baik dari sisi pengusaha, buruh maupun karyawan. Maka dari itu, peneliti bermaksud melakukan analisis sentimen untuk memahami respons publik terhadap kebijakan tersebut dengan menggunakan algoritma Naive Bayes. Data penelitian dikumpulkan dari media sosial seperti twitter sejumlah 395 data tweet dengan hastag #kenaikanumk, kemudian dilakukan pemrosesan dengan metodologi KDD yang selanjutnya dilakukan pelabelan otomatis menggunakan libray text bloob dan dikategorikan ke dalam tiga jenis sentimen: positif, negatif, dan netral. Berdasarkan hasil performance penelitian, analisis sentiment terhadap kenaikan UMK mendapatkan tingkat akurasi mencapai sebesar 95% yang mengindikasikan bahwa naïve bayes sangat efektif untuk menganalisis sentimen berbasis teks, presisi sebesar 32%, recall sebesar 33%, dan f-measure sebesar 32%. Sedangkan, hasil analisis terhadap sentimen menunjukkan bahwa sebagian besar sentimen masyarakat terhadap kebijakan ini bersifat netral, namun terdapat perbedaan signifikan antara kelompok masyarakat yang mendukung dan menentang kebijakan tersebut.
Analisis dan Pengujian Kerentanan Website Menggunakan OWASP ZAP
Authors: Pramuja Inngam Fanani Galih , Muhammad Amirul Mu’min  , Tristanti Novi
Published: February 2025

Penggunaan internet sedang meningkat, dengan situs web seperti mesin pencari, e-commerce, media sosial, dan portal berita yang sering diakses. Namun, situs web ini sering memiliki celah keamanan yang dapat dieksploitasi untuk ancaman siber. Oleh karena itu penelitian ini bertujuan untuk meningkatkan ketahanan web terhadap serangan siber dan memastikan pengalaman pengguna yang lebih aman, lebih andal dan data pengguna terlindungi. OWASP ZAP adalah alat keamanan yang banyak digunakan yang membantu organisasi mengidentifikasi dan mengatasi kerentanan dalam aplikasi web. Alat ini menawarkan fitur seperti pemindaian otomatis, kemampuan pengujian manual, dan fungsionalitas pelaporan yang komprehensif. Analisis kerentanan berbasis OWASP ZAP membantu mengidentifikasi tingkat keamanan aplikasi web melalui metode pemindaian pasif dan aktif, mendeteksi celah keamanan seperti injeksi SQL, skrip lintas situs, dan konfigurasi yang tidak aman. Temuan kerentanan seperti A01, A03, A04, A05, A06, A08, dan A09 yang mencakup ancaman seperti Cross-Site Scripting (XSS), Clickjacking, dan Man-in-the-Middle menyoroti pentingnya penerapan langkah-langkah mitigasi untuk melindungi keamanan situs web. Penerapan solusi seperti konfigurasi header keamanan (CSP, HSTS, dan X-Frame Options) serta perlindungan terhadap data sensitif sangat penting untuk mencegah eksploitasi. Sehingga dalam pencegahannya diperlukan penerapan protokol enkripsi, pembaruan perangkat lunak secara berkala, pelaksanaan penilaian kerentanan, dan pelatihan karyawan tentang praktik terbaik keamanan siber
Current Opportunities of Litholytic Therapy in Multiple Bilateral Uric Acid Nephrolithiasis
Authors: Vozianov Oleksandr , Sahalevych Andriy
Published: February 2025

Uric acid urolithiasis accounts for approximately 10% of all urostone cases worldwide, with a higher risk in male patients, obesity (body mass index > 30) and type 2 diabetes. Excessive intake of dietary acids combined with impaired buffering are risk factors that contribute to the formation of kidney stones in these patients. When the level of uric acid in the blood increases and the pH of urine decreases, an excess of uric acid occurs, which leads to the formation of urate stones.
The American and European Urological Associations recommend oral alkalinizers such as potassium citrate or sodium bicarbonate in the treatment to prevent the formation and induce dissolution of uric acid stones by increasing urine pH under dynamic control. Drugs are also actively used to reduce the level of uric acid in the blood.
We present a clinical case of the effective use of litholytic therapy in a patient with multiple bilateral uric acid nephrolithiasis. For 2 months, the patient received a course of antiseptic and litholytic therapy with correction of the nutritional regime.
The result of the treatment was complete litholysis of both kidney stones with a constant decrease of hyperuricemia, stabilization of urine pH in the range of 6.2–6.8 and the absence of bacterial growth in urine during of treatment.
Perancangan Sistem Informasi Pelayanan Akademik Berbasis Recommender System
Authors: Muhamad Faza Almaliki  , Musaruddin Mustarum , Tari Mokui Hasmina
Published: February 2025

This study aims to develop an academic service information system based on a recommender system in the Department of Computer Engineering at UHO to address challenges in managing academic documents and enhancing user satisfaction. The methods employed include needs analysis, web-based system prototype development, and evaluation using Black Box Testing to ensure system functionality. The implementation of the User-Based Collaborative Filtering (UBCF) algorithm enables the system to provide personalized recommendations to students, assisting them in accessing relevant information while reducing the administrative burden on academic staff. The results of this study indicate that the system is effective in improving academic service efficiency and can serve as a reference for developing similar services in other educational institutions
Pengembangan Aplikasi Mobile Reservasi Makeup Artist Menggunakan Metode Agile
Authors: Saputra Ferdyn , Ikrimach Ikrimach
Published: February 2025

This research aims to develop a mobile-based makeup artist reservation system at Tanti Makeup Studio to overcome the limitations of conventional booking methods. The current manual reservation system through phone calls or walk-ins has caused several challenges, including scheduling conflicts, inaccurate booking records, lack of visibility into incoming reservations, and operational inefficiencies that hinder business growth. This research utilizes Agile methodology, which incorporates iterative development cycles and continuous feedback integration. Data collection used primary sources through interviews and direct observation, and secondary sources through literature study. The system development process includes requirements analysis, conceptual design, and is followed by implementation and black box testing. The results showed successful implementation of key features including user authentication, package management, scheduling, and payment processing, with all components achieving conformance in functionality testing. The mobile app effectively streamlines the booking process, improves operational efficiency, and enhances customer experience through an intuitive interface and integrated payment system. User validation through a survey of 51 respondents showed strong positive results: 80.4% rated the application as overall easy to use (51% “very easy” and 29.4% “easy”), 86.2% gave high ratings for ease of booking (52.9% highest rating, 33.3% second highest), 80.4% expressed satisfaction with the integrated payment system, 86.3% reported improved time efficiency in the booking process, and 82.4% felt that the confirmation and scheduling process became more efficient. This study concludes that the implemented system successfully overcame the initial challenges of the manual booking process, providing a comprehensive solution for both service providers and customers in the makeup service industry
Pemanfaatan Teknologi Firebase Pada Perancangan Aplikasi Reservasi Salon Berbasis Android
Authors: Sari Agnesta Linda , Sutarman Sutarman
Published: February 2025

This study developed a salon reservation application based on Android, utilizing Firebase technology as its backend. The application aims to simplify the online reservation process and enhance the efficiency of salon operational management. The methods applied include observation, system design, implementation, and testing. Data was collected through interviews with salon owners, employees, and customers to determine system requirements. The application was built using the Kotlin programming language on the Android Studio platform. Firebase was utilized to provide user authentication, real-time data storage, notification management, and service schedule handling. Testing was conducted using the Black Box method to evaluate functionality without examining the source code. The results showed that features such as login, registration, service selection, scheduling, and notifications performed as expected. Feasibility evaluation involving 47 respondents through questionnaires indicated a high level of satisfaction, with percentage scores ranging from 83.51% to 91.85%. The application successfully improves the efficiency of reservation processes and facilitates real-time reservation data management. The findings conclude that this application effectively addresses issues related to manual reservation systems. Future development may include adding online payment features and enhancing application performance to improve user experience
علاقة الرشاقة والقوة المميزة بالسرعة بمهارة الدحرجة لدى لاعبي مركز الموهبة التخصصي/ الرصافة بأعمار (13-14) سنة بكرة القدم
Authors: صالح رائد سلمان
Published: February 2025

هدف البحث الى التعرف على العلاقة بين الرشاقة والقوة المميزة بالسرعة بمهارة الدحرجة لدى لاعبي مركز الموهبة التخصصي بكرة القدم واستخدم الباحث المنهج الوصفي بأسلوب العلاقات الارتباطية وتم اختيار العينة بالطريقة العمدية بأعمار 13 14 ) سنة والبالغ عددهم (10) لاعبين وقام الباحث باجراء التجانس لافراد العينة من ناحية العمر والطول والوزن والعمر التدريبي وتم تحديد اهم القدرات البدنية والمهارات الاساسية من خلال استمارة تم توزيعها على السادة الخبراء والمختصين واستنتج الباحث بان هناك علاقة ارتباط قوية بين الرشاقة والقوة المميزة بالسرعة مع مهارة الدحرجة لأفراد عينة البحث وهذا يدل على ان هناك عامل ايجابي يدل على نوعية التدريب المقدمة للاعبين واهتمام خاص في تطوير هذه القدرات التي تعد احد اساسيات النجاح في اعداد لاعبي كرة القدم على مستوى عالي ويوصي الباحث باستخدام التمارين والادوات التي تساعد على تطوير القدرات البدنية واجراء اختبارات دورية للقدرات البدنية لتقيم مستوى اللاعبين والتي على اساسها يتم وضع
مناهجهم التدريبية باسلوب علمي ودقيق وفق المراحل التدريبية المختلفة
Bridging the Soteriological-Secular Divide: A 9-Month Online Tibetan Mind-Body Practice Program Enhances Eudaimonic Well-Being and Non-Dual Awareness
Authors: Ehmann Sebastian , Pohlig Ryan T. , Chaoul Alejandro , Cuzzupe John , Vaughn Marcy , Rocco Gabriel , Wangyal Tenzin , Gawrysiak Michael
Published: February 2025

OBJECTIVES: As contemplative science continues to evolve, research has shifted from studying the mental health outcomes of brief meditation programs for novice practitioners to investigating traditional meditative paradigms and their associated advanced soteriological aims. However, empirical studies on meditative development remain limited. METHODS: The present study examined the effects of The 3 Doors Compassion Project (3DCP), a nine-month online program teaching traditional Tibetan Mind-Body (TMB) meditation practices rooted in Bon Dzogchen philosophy. The study hypothesized incremental improvements in compassion for self and others, mindfulness, flourishing, and non-dual awareness—a self-transcendent psychological construct central to advanced meditation. Participants (n = 30), predominantly experienced meditators, completed validated self-report measures monthly. RESULTS: General linear mixed modeling revealed incremental increases across all assessed outcomes with statistically significant improvements for compassion for self and others, mindfulness, flourishing (p < .001), and non-dual awareness (p < .05). Notably, improvements were independent of self-reported frequency of meditation practice, suggesting that program structure rather than practice quantity influenced outcomes. CONCLUSIONS: These findings extend prior research on the mental health benefits of TMB programs and provide preliminary evidence that TMB practices may foster advanced meditative states associated with self-transcendence. Limitations include the small, self-selected sample, lack of a control group, and reliance on quantitative measures, which may underrepresent the richness of advanced meditative phenomenology. Future research should incorporate qualitative methods, larger and more diverse samples, and unified empirical frameworks to further elucidate the mechanisms and outcomes of traditional TMB practices, particularly their potential to cultivate self-transcendence and eudaimonic well-being.
Stabilization of Telomeric G-Quadruplex Structures for potential treatment of Cancer
Authors: Improta Alexandra , Eunice Denial
Published: February 2025

The stabilization of telomeric G-quadruplex (G4) structures has emerged as a compelling strategy in cancer therapeutics. These four-stranded DNA configurations, prevalent at chromosomal ends, play pivotal roles in maintaining genomic integrity and regulating cellular proliferation. This review delves into the mechanisms by which stabilizing telomeric G4 structures can impede cancer cell growth, explores the potential of truncated G-quadruplexes in cancer treatment, and discusses the therapeutic implications of targeting these unique DNA formations.
Non-Canonical DNA Structures Diversity, Functions, and Implications
Authors: Improta Alexandra , Eunice Denial
Published: February 2025

DNA, traditionally visualized as the canonical right-handed B-form double helix, demonstrates remarkable structural diversity under physiological and stress conditions. Non-canonical DNA structures, including G-quadruplexes, Z-DNA, H-DNA, triplex DNA, and i-motifs, play pivotal roles in gene regulation, genomic stability, and chromosomal architecture. These structures are not only essential in natural cellular processes but are also implicated in pathological states such as cancer, neurodegenerative diseases, and genetic disorders. This review provides an in-depth analysis of the structural features, mechanisms of formation, biological significance, and therapeutic potential of non-canonical DNA structures. Moreover, we highlight current technological advancements and challenges in studying these structures, aiming to bridge knowledge gaps in their biomedical applications.
Reduced Costs of Managing Adverse Reactions with DT3aP-HBV-IPV/Hib Versus DT2aP-HBV-IPV-Hib in Vietnam: Results of a Cross-Sectional Survey and Mathematical Projections of Vaccination of Infants
Authors: Mohy Ahmed , Nikitas Georgios , Duchenne Maurine , Genovez Victoria , Casabona Giacomo , Hennessy Elizabeth , Nguyen Minh , DeAngelis Elena , Marijam Alen , Van Oorschot Désirée
Published: February 2025

In Vietnam, hexavalent vaccines are routinely given during early childhood. Hexavalent vaccines DT3aP-HBV-IPV/Hib and DT2aP-HBV-IPV-Hib differ in composition and therefore, reactogenicity, with DT3aP-HBV-IPV/Hib shown to cause fewer adverse reactions (ARs) than DT2aP-HBV-IPV-Hib. Online surveys for physicians and parents/caregivers who manage post-vaccination ARs in children were used to explore AR management in the Vietnamese private healthcare setting. Survey data were used to estimate healthcare resource utilization (HCRU) and its associated costs, and indirect costs to parents/caregivers. A mathematical projection tool used survey results to approximate the difference in costs associated with post-vaccination childhood AR management following primary doses of DT3aP-HBV-IPV/Hib versus DT2aP-HBV-IPV-Hib. Parent/caregiver attitudes towards childhood vaccination in relation to management of ARs in their children were also explored. Around a third of parents/caregivers in Vietnam reported that their child experienced post-vaccination AR(s), the management of which led to significant HCRU and indirect costs to parents/caregivers. A primary dose of DT3aP-HBV-IPV/Hib compared with DT2aP-HBV-IPV-Hib led to 420 985 fewer ARs in Vietnam. Subsequently, HCRU burden and associated direct costs were reduced by ~11% and indirect costs to parents/caregivers were reduced by 14%. Parents/caregivers reported indirect costs of ~3 million VND per parent/caregiver per AR to manage ARs in their children. Additionally, parents/caregivers reported notable emotional concerns over ARs of rashes, diarrhea, and fever. However, despite costs and emotional burdens, most parents/caregivers did not express hesitancy toward future vaccinations. The substantial financial benefits of a vaccine with fewer ARs should be considered from a cost effectiveness perspective by decision-makers when evaluating vaccine alternatives.
Simultaneity based on momentum conservation
Authors: Qu Wenjing
Published: February 2025

The relativity of simultaneity was proposed by Einstein in order to harmonize the results of the Lorentz transformation of special relativity. However, there are mathematical and logical flaws in the deductions of the Lorentz transformation, such as in the deduction of the time dilation from t’=γ(t-vx/c2) and x’=γ(x-vt), i.e., when x’=0 in x’=γ(x-vt), we obtain x=vt; substitution of this equation into t’=γ(t-vx/c2) yields t’=t/γ; however, the equation x=vt is inconsistent with the prerequisite equation x=ct. Here, an absolute simultaneity based on momentum conservation is proposed, according to which it is revealed that x’=ct’ is incorrect; according to Space Motion Theory, the reason why x’=ct’ incorrect is attributed to red‒shift‒induced position velocity variation of photons. Furthermore, how the relativity of simultaneity defends the equations x’=ct’ and t’=γ(t-vx/c2) is pointed.
Towards Sustainable Adoption: Investigating QR Codes Mobile Payment Continuance in Tanzania
Authors: Koloseni Daniel , Mandari Herman
Published: February 2025

The adoption of QR codes in the payment of various services has grown and deepened financial inclusion in Tanzania. Despite its initial acceptance, the sustainability of using QR codes for payment is unknown. Based on that, this study examines the continuance intention of using QR codes for payment in Tanzania by extending the Technology Continuance Theory (TCT) to assess the moderating effects of perceived risks and perceived service trust. A convenient sampling technique was employed to identify respondents. Online and paper-and-pencil techniques were used to distribute the questionnaire. Among the received responses, 271 responses were considered to be valid and reliable for data analyses. Partial List Square Structural Equation Modeling (PLS-SEM) was employed to evaluate the hypothesised relationships. Findings from this study show that perceived usefulness, confirmation, and ease of use significantly influence attitude and satisfaction. Moreover, satisfaction, attitude, perceived risk, perceived usefulness, and perceived service trust significantly influence the continuance of QR codes for mobile payments in Tanzania. The study also found that perceived risk and perceived service trust moderate the relationships between attitude and continuance usage of QR codes. The implications from this study have been provided to enable financial service providers and policymakers to enhance how QR code services and infrastructures should be implemented and enhanced for sustainability in Tanzania.
Revolutionizing Fitness: The Intersection of Artificial Intelligence and Physical Activity
Authors: Donkor Simon Kormla
Published: February 2025

The rapid advancement of artificial intelligence (AI) technology is significantly reshaping the fitness industry, creating opportunities for enhanced personalization and effectiveness in exercise routines. This study explored the transformative impact of AI-powered wearables and smart fitness devices on individual fitness outcomes and overall physical activity levels. Utilizing a quantitative approach, the research involved a cross-sectional survey of 90 pre-service physical education students from the University of Education, Winneba, who provided insights into their experiences with AI technologies in fitness. The study employed a five (5) point Likert-scale questionnaire to assess respondents’ perceptions of AI's influence on their exercise regimens. Data was analyzed using means, standard deviation, independent samples t-test and Pearson’s correlation. The findings revealed that AI technologies significantly enhance the personalization of fitness programmes, enabling users to achieve tailored workout structures and set personalized fitness goals. Participants reported increased physical activity levels and improved consistency in their fitness routines, highlighting the positive correlation between AI integration and individual fitness outcomes. Additionally, the study emphasizes the necessity of addressing ethical considerations, in terms of algorithmic partiality and data confidentiality, to ensure equitable access to AI-driven fitness solutions. It was recommended that fitness organizations and AI developers should focus on user education, engagement, and continuous improvement of user experience to maximize the benefits of AI technologies.
Multilingualism and Working Memory: The Role of Formal vs. Informal Language Learning
Authors: Mohammed Amin , Rampinini Alessandra , Balboni Irene , Berthele Raphael , Golestani Narly , Kepinska Olga
Published: February 2025

The impact of multilingualism on executive functioning remains a topic of debate, with prior research suggesting minimal effects and limited real-world benefits. This study investigated whether multilingualism is related to performance and examined the role of formality in language acquisition (formal vs. informal) in modulating this relationship. A sample of 116 adults completed six working memory tasks and a language experience questionnaire, from which degree of multilingualism and formality of language acquisition were computed, using an entropy equation and a newly developed metric. Two different approaches were used to quantify formal and informal language learning: one that weighted language proficiencies using our new metric and another that categorized experiences using cut-off derived from such metric. The internal structure of measures underlying the working memory component was determined using principal component and parallel analyses, and regression models controlled for age, sex, and education. We found that a numerical-verbal working memory component explained 47.11% of the variance. No significant association emerged between overall multilingualism and working memory. However, at certain thresholds of the acquisition formality metric we developed, formal language acquisition was positively correlated with working memory, while informal acquisition was negatively related. Results support the idea that the relationship between multilingualism and working memory is nuanced, with formality of language acquisition modulating it. Future research should address the mechanisms underlying this complex relationship (e.g., causality, learning and memory mechanisms underlying formal versus informal learning and their relationship with executive function, etc.), and should consider acquisition formality as an important key variable in modulating multilingualism’s cognitive effects.
Quality in Question: Assessing the accuracy of four heart rate wearables and the implications for psychophysiological research.
Authors: Sinichi Mohammadamin , Gevonden Martin , Krabbendam Lydia
Published: February 2025

[PLEASE NOTE: This work is now published in Psychophysiology. Please refer to the open-access, peer-reviewed version of this work at: https://doi.org/10.1111/psyp.70004]Heart rate (HR) and heart rate variability (HRV) are two key measures with significant relevance in psychophysiological studies, and their measurement has become more convenient due to advances in wearable technology. However, photoplethysmography (PPG)-based wearables pose critical validity concerns. In this study, we validated four PPG wearables: three consumer-grade devices (Kyto2935, Schone Rhythm 24, and HeartMath Inner Balance Bluetooth) and one research-grade device (Empatica EmbracePlus, successor to the widely-used but discontinued Empatica E4). All devices were worn simultaneously by 40 healthy participants who underwent conditions commonly used in laboratory research (seated rest, arithmetic task, recovery, slow-paced breathing, a neuropsychological task, posture manipulation by standing up) and encountered in ambulatory-like settings (slow walking and stationary biking), compared against a criterion electrocardiography device, the Vrije Universiteit Ambulatory Monitoring System (VU-AMS). We determined the signal quality, the linear strength through regression analysis, the bias through Bland-Altman analysis, and the measurement error through mean arctangent absolute percentage error for each condition against the criterion device. We found that the research-grade device did not outperform the consumer-grade devices in laboratory conditions. It also showed low agreement with the ECG in ambulatory-like conditions. In general, devices captured HR more accurately compared to HRV. Finally, conditions that deviated from baseline settings and involved slight to high movement, negatively impacted the agreement between PPG devices and the criterion. We conclude that PPG devices, even those advertised and designed for research purposes, may pose validity concerns for HRV measurement in conditions other than those similar to resting states.
Orienteering Venetian Style
Authors: Lomax Joseph
Published: February 2025

"Walk between campi, not along calli." That is, walk between the piazzas (as they would say in the rest of Italy), not down streets. This is the native, though not formalized, navigation method of Venice. For the visitor, it gives in a nutshell a method to orienteer in Venice. It does not avoid getting lost (a pleasure in Venice), but allows one to not worry that you are lost. One does this with a sparse map with only the outlines of the canals and campi of Venice, available in Supplements. How the historical structure of Venice evolved from Church to Campo to Neighborhood to a compilation of neighborhoods leads to is discussed and examples are given.
Educational Experiences of United States Children during the 2020-2021 School Year in the Context of the COVID-19 Pandemic
Authors: Johnson Rachelle Margaret , Little Callie W. , Shero Jeffrey , van Dijk Wilhelmina , Holden LaTasha R , Daucourt Mia Cristina , Norris Cynthia Ulysse , Ganley Colleen Marie , Taylor Jeanette , Hart Sara Ann
Published: February 2025

The COVID-19 pandemic is a historic event impacting children around the globe. Prior research on the educational experiences of children during the COVID-19 pandemic focused almost exclusively on spring 2020. This paper extends this literature past the initial shock of spring 2020, capturing the first full school year (2020-2021) during the COVID-19 pandemic. This registered report study utilized a national sample of 1,666 United States twins in kindergarten through twelfth grade from 43 states to provide the current descriptive report of children’s educational experiences during this time, as reported by their parents. Specifically, we reported on school format, parents’ role in education, parent-teacher interactions, schoolwork struggles, technology access, and school services. About half of children attended in-person schooling, with many children switching from online to in-person throughout the school year. Parents saw the pandemic as a risk to their children’s education. During the 2020-2021 school year of the pandemic parents felt they had a larger role in their children’s education and were less satisfied in their interactions with teachers than what they experienced during the pre-pandemic part of the 2019-2020 school year. Children experienced more schoolwork struggles than they had in previous years, and this was similar across age groups. For most constructs, results were equivalent across age groups, but parents of younger children tended to provide more schoolwork help. Overall, this paper highlights the disruptions in their educational environments that children continued to experience though the first full school year (2020-2021) of the COVID-19 pandemic.
Object-Based Practice Effects Recover the Graphic Object Concept in Alzheimer’s Dementia
Authors: Bechari-Martin Hind Sara , Lange-Küttner Chris
Published: February 2025

The current study tested object drawing, object naming and object-in-scene perception. We tested older people with Alzheimer’s dementia (AD) because their object drawings have often lost their typical contours. We investigated whether intensive practice could improve or recover deteriorated graphic object representations in three tasks, object naming, object-in-scene and object drawing. Ten older participants with AD and ten healthy controls practiced for five consecutive days always involving the same ten objects (item-based learning). Patients with AD closed the gap to healthy controls as reaction time decreased and accuracy increased. Performance level and task difficulty was dependent on age, education and length of retirement duration, but interactions between practice and task difficulty were not. In accuracy, the group difference disappeared earlier in object naming < object-in-scene < object drawing. During the five days of practice, lost graphic object concepts could re-emerge. Multiple regressions testing synergistic effects between tasks showed that rapid object-in-scene judgment and drawing time relatively consistently and reliably predicted object drawing accuracy. However, when testing day-to-day progress of the drawing score, after the first repetition, only the object drawing score of the previous session significantly predicted the graphic object representation. Thus, while perceptual judgment of an object in an appropriate visual scene predicts object drawing - just as in previous research using the Witkin Embedded Figures Test – the fine motor skills involved in visually realistic drawing are likely to be the most important factor to generate a recognizable graphic object representation.
भाषिक सन्दर्भ : भाषिक भूगोल, आगमन, सम्मिलन र मृत्यु
Authors: सुवेदी Subedi सखिशरण Sakhisharan
Published: February 2025

भाषा विचार विनिमयको सशक्त माध्यम हो । भाषाका उच्चार्य र लेख्य दुई रूप हुन्छन । भाषामा मानव जीवनको प्रतिबिम्ब हुने हुनाले मानव सभ्यतासँग भाषाको तादात्म्य सम्बन्ध रहन्छ । यसैले भाषालाई मानव ज्ञानका विविध क्षेत्र, सन्दर्भ र विषयका कोणबाट हेर्नु पर्ने  हुन्छ । मानवीय व्यवहारका समग्र सन्दर्भहरू भाषामा समेटिने हुनाले भाषाको प्रयोग क्षेत्र, एउटा भाषामा अर्को  भाषाका शब्दहरू आगमन हुँदा त्यसबाट पर्ने  प्रभाव तथा भाषाको प्रयोग नै हराउने अवस्था देखापर्न सक्दछ । भाषिक वक्ताको प्रयोग क्षेत्र, बाक्लो र पातलो बस्ती क्षेत्र आदि कुराका बारेमा तयार पारिने नक्साङकन भाषिक भूगोल हो । भाषिक भूगोलभित्र प्रयोगमा रहेका भाषाहरूमध्ये दाता भाषाअनुसार ग्राहक भाषामा पर्ने  प्रभाव र भाषिक व्यवस्था ग्रहण गर्ने  प्रक्रिया आगमन हो । भाषिक आगमन स्रोत भाषाबाट, भाषिकाबाट र विविध भाषाबाट हुन सक्छ । दुई फरक भाषाहरू विविध कारणबाट एक अर्काको सम्पर्कमा आई एउटै बन्नु भाषिक सम्मिलन हो । यसरी फरक फरक भाषाहरूको सम्पर्कबाट बन्ने नयाँ भाषिक रूप पिजिन हो । भाषाको पिजिन रूप मातृभाषाको तहमा पुगेर विकसित भइसकेको अवस्था क्रेओल हो । सामाजिक, भौगोलिक राजनैतिक, धार्मिक आदिका कारण वक्ता र समुदायबाट भाषाको प्रयोग समाप्त हुनु भाषिक मृत्यु हो ।
चलचित्र, साहित्य र नेपाली सन्दर्भ
Authors: थापा Thapa अशोक Ashok
Published: February 2025

प्रस्तुत लेखमा चलचित्रको परिचय दिनाको साथै साहित्यका अन्य विधासँग चलचित्रको अन्तर्सम्बन्धलाई उल्लेख गरिएको छ । यहाँ नेपाली चलचित्रको सङक्षिप्त इतिहास उल्लेख गर्दै लेखलाई थप चुस्त बनाउन निगमन तथा तुलनात्मक शोधविधिको प्रयोग गरिएको छ । द्वितीयस्रोतबाट सामग्रीसङ्कलन गरिएको प्रस्तुत लेखमा पुस्तकालयकार्यलाई सामग्रीको पहिलो स्रोत मानिएको छ । यहाँ वर्तमान समयमा चलचित्र मानवजातिको मनोरञ्जनको अभिन्न अङ्गका रूपमा रहेकाले चलचित्रलाई छुट्टै विधाका रूपमा विकास हुँदैआएको निष्कर्ष निकालिएको छ । चलचित्रको प्राविधिक पक्षमा प्रवेश नगर्नु यस कार्यपत्रको सीमा हो भने सैद्धान्तिक भन्दा अवधारणामूलक बन्नु यसको अर्को सीमितता हो । प्रस्तुत कार्यपत्रमा चलचित्रको परिभाषा, विकासक्रमका विषयमा पनि प्रकाश पारिएको छ । यहाँ चलचित्रको सामाजिक, सांस्कृतिक र सैद्धान्तिक पक्षहरूको छोटो अध्ययन गरिएको छ । चलचित्रको मनोरञ्जनात्मक पक्षलाई प्राथमिकतामा राख्दै यसले समाजमा पार्ने प्रभाव र यसको विकासक्रमको विश्लेषण गरिएको छ । प्रस्तुत कार्यपत्रले चलचित्र साहित्यिक उपशाखा नभएर स्वतन्त्र विधा हो भन्ने मान्यतालाई स्थापित गरेको छ ।  प्रस्तुत लेखमा आजको समयमा चलचित्रलाई पृथक पहिचान भएको विधाका रूपमा मान्यता प्राप्त भएको निष्कर्ष निकालिएको छ ।
वासुदेव त्रिपाठीको विधागत साहित्येतिहास चेतना
Authors: अधिकारी Adhikari बालाकृष्ण Balakrishna
Published: February 2025

प्रस्तुत लेखमा वासुदेव त्रिपाठीका समालोचनात्मक कृतिमा निहित साहित्येतिहास चेतनाको विमर्श गरिएको छ । नेपाली साहित्यको बहुआयामिक र बहुलवादी समालोचना गर्ने समालोचक वासुदेव त्रिपाठीका समालोचनात्मक प्रवृत्तिमध्येको सबैभन्दा सशक्त प्रवृत्ति ऐतिहासिक समालोचना र साहित्येतिहासपरक समालोचना हो । साहित्येतिहासपरक समालोचक वासुदेव त्रिपाठीका समालोचनाकृतिहरू नै यस लेखका आधारसामग्री हुन । ती आधारसामग्रीको सत्यापन र अर्थापनका लागि यस लेखमा इतिहास दर्शन र साहित्येतिहास दर्शनको संश्लेषणात्मक अन्तप्र्रयोग गरिएको छ । क्षितिजीय आयाममा विषयको विश्लेषण गरिएको यस लेखमा गुणात्मक अध्ययनविधि अवलम्बन गरिएको छ । वासुदेव त्रिपाठीका लगभग एक दर्जनजति समालोचनाकृतिमा निहित उनको साहित्येतिहास दृष्टि, साहित्येतिहास बोध, साहित्येतिहास चिन्तन र साहित्येतिहास दर्शनको विमर्श गरी उनका साहित्येतिहास चेतनाको सामान्यीकरण गरिएको छ । लेखको शीर्षकअनुकूलका तथ्यहरूको विश्लेषण गर्दा वासुदेव त्रिपाठीका समालोचनाकृतिमा साहित्येतिहास चेतनालाई आधारभूमि बनाइएको एवं यस्तो चेतना पूर्वीय सनातन संस्कृति, मूल्य र मान्यता तथा पाश्चात्य साहित्येतिहास दर्शनको संश्लेषणबाट निर्माण भएको निष्कर्ष निकालिएको छ ।
Breves antecedentes intelectuales, económicos y políticos de la Reforma Protestante
Authors: Mora Castro Luis Angel
Published: February 2025

Mora Castro, Luis Angel. Breves antecedentes intelectuales, económicos y políticos de la Reforma Protestante. En este trabajo se revisan los principales elementos históricos necesarios para comprender el contexto en el que la Reforma vio la luz. Por una parte se exponen brevemente los datos biográficos de Martín Lutero y tres de los antecedentes intelectuales de este fraile agustino conocido como el principal exponente de la Reforma. Por otra parte se esbozan las características de la situación política y económica dentro de la cual Lutero se forjó como Reformador.
Apuntes sobre espacio y justicia
Authors: López Vergara Newton Juan
Published: February 2025

López Vergara Newton, Juan. Apuntes sobre espacio y justicia. El siguiente texto explora, a partir de algunas ideas de Peter Sloterdijk, la relación que existe entre el espacio y la justicia en el mundo contemporáneo. Se analizan, de forma general, dos perspectivas a través de las cuales comprendemos el espacio para, posteriormente, contrastarlas con aquello que Sloterdijk denomina la “espacialidad del palacio de cristal”. Por último, a la luz de tales consideraciones, se ofrecen algunas reflexiones en torno a la vivienda de interés social en México, y se sugiere la relevancia que tendrá, en los próximos años, la forma en que enfrentemos el tema del espacio.
Fundamentos históricos y jurídicos de la Constitución mexicana
Authors: Estrada Michel Rafael
Published: February 2025

Estrada Michel, Rafael. Fundamentos históricos y jurídicos de la Constitución mexicana. A través de la integración de diversos enfoques —el histórico, el jurídico y el filosófico—, el texto que a continuación se presenta reflexiona sobre la tensión esencial que conforma el constitucionalismo moderno, en general, y el mexicano, en particular. La tensión aludida es aquella que se establece entre el principio de soberanía y los contenidos fundamentales asociados con la noción de garantía.