bluuebunny/crossref_metadata_2025 huggingface dataset:
Differences in skin test reactions to official and defined antigens in guinea pigs exposed to non-tuberculous and tuberculous bacteria
Authors: Fernández-Veiga Leire , Fuertes Miguel , Geijo María V. , Pérez de Val Bernat , Vidal Enric , Michelet Lorraine , Boschiroli María Laura , Gómez-Buendía Alberto , Bezos Javier , Jones Gareth J. , Vordermeier Martin , Juste Ramón A. , Garrido Joseba M. , Sevilla Iker A.
Published: February 2023

The single and comparative intradermal tuberculin tests (SITT and CITT) are official in vivo tests for bovine tuberculosis (TB) diagnosis using bovine and avian purified protein derivatives (PPD-B and PPD-A). Infection with bacteria other than Mycobacterium tuberculosis complex (MTC) can result in nonspecific reactions to these tests. We evaluated the performance of the skin test with PPDs and new defined antigens in the guinea pig model. A standard dose (SD) of Rhodococcus equi, Nocardia sp., M. nonchromogenicum, M. monacense, M. intracellulare, M. avium subsp. paratuberculosis, M. avium subsp. avium, M. avium subsp. hominissuis, M. scrofulaceum, M. persicum, M. microti, M. caprae and M. bovis, and a higher dose (HD) of M. nonchromogenicum, M. monacense, M. intracellulare, M. avium subsp. paratuberculosis were tested using PPD-B, PPD-A, P22, ESAT-6-CFP-10-Rv3615c peptide cocktail long (PCL) and fusion protein (FP). The SD of R. equi, Nocardia sp., M. nonchromogenicum, M. monacense, M. intracellulare and M. avium subsp. paratuberculosis did not cause any reactions. The HD of M. nonchromogenicum, M. monacense, M. intracellulare, and M. avium subsp. paratuberculosis and the SD of M. avium subsp. hominissuis, M. scrofulaceum and M. persicum, caused nonspecific reactions (SIT). A CITT interpretation would have considered M. avium complex and M. scrofulaceum groups negative, but not all individuals from M. nonchromogenicum HD, M. monacense HD and M. persicum SD groups. Only animals exposed to M. bovis and M. caprae reacted to PCL and FP. These results support the advantage of complementing or replacing PPD-B to improve specificity without losing sensitivity.
Asymmetric response of South Asian summer monsoon rainfall in a carbon dioxide removal scenario
Authors: Zhang Suqin , Qu Xia , Huang Gang , Hu Peng
Published: February 2023

The reversibility of South Asian summer monsoon (SASM) precipitation under the CO2 removal scenario is critical for climate mitigation and adaptation. In the idealized CO2 ramp-up (from 284.7 to 1138.8 ppm) and symmetric ramp-down experiments, SASM precipitation is largely reversible while exhibiting strong asymmetry: it may overshoot the unperturbed level when CO2 recovers. Such asymmetric response is mainly due to the enhanced El Niño-like and Indian Ocean dipole-like warming during the ramp-down period. The uneven sea surface warming weakens Walker circulation, with anomalous sinking over the SASM region. Meanwhile, the warming also affects the rainfall over the Maritime Continent and tropical western Indian Ocean. The suppressed rainfall over the Maritime Continent triggers the equatorial Rossby wave, which weakens the ascent over the SASM region; the increased rainfall over the tropical western Indian Ocean excites the equatorial Kelvin wave, which reduces moisture transport. Additionally, tropic-wide warming reduces the land-sea thermal contrast and weakens monsoonal circulation. Consequently, the combined effects of the weakened ascent and moisture transport lead to the overshooting of SASM rainfall. Our results suggest that symmetric CO2 removal, although unlikely in the foreseeable future, may result in a risk of local drought over the SASM region.
Pan-cancer clinical impact of latent drivers from double mutations
Authors: Yavuz Bengi Ruken , Tsai Chung-Jung , Nussinov Ruth , Tuncbag Nurcan
Published: February 2023

Here, we discover potential ‘latent driver’ mutations in cancer genomes. Latent drivers have low frequencies and minor observable translational potential. As such, to date they have escaped identification. Their discovery is important, since when paired in cis, latent driver mutations can drive cancer. Our comprehensive statistical analysis of the pan-cancer mutation profiles of ~60,000 tumor sequences from the TCGA and AACR-GENIE cohorts identifies significantly co-occurring potential latent drivers. We observe 155 same gene double mutations of which 140 individual components are cataloged as latent drivers. Evaluation of cell lines and patient-derived xenograft response data to drug treatment indicate that in certain genes double mutations may have a prominent role in increasing oncogenic activity, hence obtaining a better drug response, as in PIK3CA. Taken together, our comprehensive analyses indicate that same-gene double mutations are exceedingly rare phenomena but are a signature for some cancer types, e.g., breast, and lung cancers. The relative rarity of doublets can be explained by the likelihood of strong signals resulting in oncogene-induced senescence, and by doublets consisting of non-identical single residue components populating the background mutational load, thus not identified.
Application of the neuropeptide NPVF to enhance angiogenesis and osteogenesis in bone regeneration
Authors: Yu Hongping , Wang Yanyi , Gao Junjie , Gao Youshui , Zhong Chao , Chen Yixuan
Published: February 2023

The brain-bone regulatory system regulates skeletal homeostasis via bioactive neuropeptides, yet the underlying mechanism remains elusive. Here, we report the role of the neuropeptide VF (NPVF, VPNLPQRF-NH2) in enhancing both angiogenesis and osteogenesis in a rat skeletal system and the potential pathways involved. An in vitro study revealed that NPVF not only promotes migration and angiogenesis of human umbilical vein endothelial cells (HUVECs) by activating NPFFR1, which leads to upregulation of miR-181c-3p and downregulation of Argonaute1 (AGO1), but also mediates osteogenic differentiation of bone mesenchymal stem cells (BMSCs) via the Wnt/β-catenin signaling pathway. To improve the stability and bioavailability and thus efficacy of NPVF as a promoter of in vivo bone regeneration, we genetically engineered amyloid-NPVF-fusion proteins and utilized them as self-assembling nanofiber coatings to treat bone defects in a rat calvarial defect model. We found that a porous hydroxyapatite scaffold loaded with the NPVF peptide-fused amyloid coating substantially enhanced angiogenesis and site-specific fresh bone in-growth when implanted in calvarial defects. Taken together, our work uncovered a previously undefined crosstalk between the brain and bone by unveiling the role of NPVF in bone tissue and demonstrated a viable method for promoting bone tissue repairs based upon self-assembling NPVF-containing protein coatings.
Measuring health and human development in cities and neighborhoods in the United States
Authors: Sheth Suraj K. , Bettencourt Luís M. A.
Published: February 2023

Human development is a complex process involving interactions between individuals and their socioeconomic, biological, and physical environments. It has been studied using two frameworks: the “Capabilities Approach,” implemented at the national scale, and the “Neighborhood Effects Approach,” implemented at the community scale. However, no existing framework conceptualizes and measures human development across geographic scales. Here, we unite the two approaches by localizing the Human Development Index (HDI), and demonstrate a methodology for scalable implementation of this index for comparative analysis. We analyzed patterns of development in the United States, characterizing over 70,000 communities. We found that, on average, larger cities have higher HDI (higher standard of living) but exhibit greater disparities between communities, and that increases in community HDI are associated with the simultaneous reduction of a diverse set of negative neighborhood effects. Our framework produces an interdisciplinary synthesis of theory and practice for sustainable, equitable urban health and development.
Higher concentrations of microplastics in runoff from biosolid-amended croplands than manure-amended croplands
Authors: Naderi Beni Nasrin , Karimifard Shahab , Gilley John , Messer Tiffany , Schmidt Amy , Bartelt-Hunt Shannon
Published: February 2023

Land-applied municipal biosolids, produced from municipal wastewater treatment sludge, contributes to microplastics contamination in agroecosystems. The impacts of biosolids on microplastic concentrations in agricultural soil have been previously investigated, however, the potential for microplastics transport from biosolid-amended croplands has not been previously quantified. In this study, manure and biosolids were applied to field plots, runoff was collected following natural precipitation events and the potential of bacterial biofilm to grow on different microplastic morphologies was investigated. Higher concentrations of microplastics were detected in runoff from plots with land-applied biosolid in comparison with manure-amended and control plots. Fibers and fragments were the most frequently detected plastic morphologies in runoff, correlated with their decreased surface roughness. The potential of biosolids to contribute to microplastic contamination to U.S. surface waters was quantified which is among the first to quantify the potential for nonpoint source microplastic contamination of surface waters adjacent to agricultural production areas.
Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits
Authors: Koutsodendris Nicole , Blumenfeld Jessica , Agrawal Ayushi , Traglia Michela , Grone Brian , Zilberter Misha , Yip Oscar , Rao Antara , Nelson Maxine R. , Hao Yanxia , Thomas Reuben , Yoon Seo Yeon , Arriola Patrick , Huang Yadong
Published: February 2023

Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear. Here we report the characterization of neuronal APOE4 effects on AD-related pathologies in an APOE4-expressing tauopathy mouse model. The selective genetic removal of APOE4 from neurons led to a significant reduction in tau pathology, gliosis, neurodegeneration, neuronal hyperexcitability and myelin deficits. Single-nucleus RNA-sequencing revealed that the removal of neuronal APOE4 greatly diminished neurodegenerative disease-associated subpopulations of neurons, oligodendrocytes, astrocytes and microglia whose accumulation correlated to the severity of tau pathology, neurodegeneration and myelin deficits. Thus, neuronal APOE4 plays a central role in promoting the development of major AD pathologies and its removal can mitigate the progressive cellular and tissue alterations occurring in this model of APOE4-driven tauopathy.
Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus
Authors: Wu Yicheng , Bottes Sara , Fisch Roberto , Zehnder Cinzia , Cole John Darby , Pilz Gregor-Alexander , Helmchen Fritjof , Simons Benjamin D. , Jessberger Sebastian
Published: February 2023

Neural stem cells (NSCs) generate new neurons throughout life in the mammalian hippocampus1. Advancing age leads to a decline in neurogenesis, which is associated with impaired cognition2,3. The cellular mechanisms causing reduced neurogenesis with advancing age remain largely unknown. We genetically labeled NSCs through conditional recombination driven by the regulatory elements of the stem-cell-expressed gene GLI family zinc finger 1 (Gli1) and used chronic intravital imaging to follow individual NSCs and their daughter cells over months within their hippocampal niche4,5. We show that aging affects multiple steps, from cell cycle entry of quiescent NSCs to determination of the number of surviving cells, ultimately causing reduced clonal output of individual NSCs. Thus, we here define the developmental stages that may be targeted to enhance neurogenesis with the aim of maintaining hippocampal plasticity with advancing age.
β-Cyclodextrin-functionalized Ti3C2Tx MXene nanohybrids as innovative signal amplifiers for the electrochemical sandwich-like immunosensing of squamous cell carcinoma antigen
Authors: Jiang Yuling , Yang Miao , Yu Mingyao , Huang Lingling , Ke Yue , Yang Lei
Published: February 2023

A highly sensitive and innovative electrochemical sandwich-like immunosensing platform was designed for the detection of the squamous cell carcinoma antigen based on β-cyclodextrin-functionalized Ti3C2Tx MXene nanohybrids as signal amplifiers.
Structural elucidation and hypoglycemic effect of an inulin-type fructan extracted from Stevia rebaudiana roots
Authors: Tang Zhiyan , Shao Taili , Gao Lan , Yuan Pingchuan , Ren Zhengrui , Tian Lei , Liu Wei , Liu Chunyan , Xu Xiuxian , Zhou Xuan , Han Jun , Wang Guodong
Published: February 2023

A novel fructan (SRRP) from S. rebaudiana roots ameliorates glucose and lipid metabolism disorders in type 2 diabetic mice via gut microbiota regulation.
Natural isoflavone formononetin inhibits IgE-mediated mast cell activation and allergic inflammation by increasing IgE receptor degradation
Authors: Zhou Zi-Wen , Ji Kunmei , Zhu Xue-Yan , Wu Xin-Ying , Lin Ruo-Tong , Xie Chu-Chu , Cai Ze-Lang , Chen Jia-Jie
Published: February 2023

Formononetin-inhibited IgE-mediated mast cell activation and attenuated IgE/Ag-induced allergic inflammation by suppressing USP5 or USP13 expression and increasing proteasome-mediated FcεRIγ degradation.
Ethanol stimuli-responsive toughening PNIPAM/PVA self-healing hydrogel thermal actuator
Authors: Zhou Cheng , Dai Shengping , Zhou Xiaoshuang , Zhu Hao , Cheng Guanggui , Ding Jianning
Published: February 2023

The combination of three strategies yields a hydrogel with a reversibly changing crosslinked structure and related properties.
Recent synthetic journey on pyrrole-fused compounds
Authors: Pramanik Chandana , Barik Paritosh , Ali Sk Asraf , Nayak Dipti Sovamayee , Ikbal Mohammed , Mandal Arabinda , Jana Rathin , Giri Soumen , Samanta Shubhankar
Published: February 2023

Pyrroles and their fused compounds are widely known as biologically active scaffolds, which are mainly fused at the 1–2 (a), 2–3 (b), 3–4 (c) and 4–5 (d) positions.
Tailor-made isostructural copper(ii) and nickel(ii) complexes with a newly designed (N,N)-donor scaffold as functional mimics of alkaline phosphatase
Authors: Kundu Subhankar , Saha Subhajit , Panda Subhra Jyoti , Purohit Chandra Shekhar , Biswas Bhaskar
Published: February 2023

This study highlights the design, synthesis, spectroscopic and computational characterization, and catalytic phosphoesterase cleavage activity of isostructural copper(ii) and nickel(ii) complexes.
Observation of the photovoltaic effect in a van der Waals heterostructure
Authors: Zhang Shaochun , Maruyama Mina , Okada Susumu , Xue Mengsong , Watanabe Kenji , Taniguchi Takashi , Hashimoto Kazuki , Miyata Yasumitsu , Canton-Vitoria Ruben , Kitaura Ryo
Published: February 2023

A van der Waals heterostructure composed of WS2/MoS2 showing a photovoltaic effect with an excitation wavelength of 633 nm.
3D printed electronics with nanomaterials
Authors: Słoma Marcin
Published: February 2023

This review focuses on the recent advances in the application of nanomaterials for 3D printed electronics, demonstrating conductive paths, electronic and photonic components, energy devices or sensors with perspectives for future developments.
Microwave-facilitated crystal growth of defect-passivated triple-cation metal halide perovskites toward efficient solar cells
Authors: Barua Pranta , In Chang Min , Lee Mi Jung , Hwang Inchan
Published: February 2023

A combined process of microwave irradiation and TOPO coordination leads to a substantially low defect density and thus suppressed non-radiative recombination owing to the in situ passivation of bulk and surface defects during the crystal growth.
Phenylalanine conjugated supramolecular hydrogels developed from the mafenide and flurbiprofen multidrug for biological applications
Authors: Manna Utsab , Roy Rajdip , Dutta Abhishek , Roy Nabanita
Published: February 2023

A multidrug hydrogelator salt of flurbiprofen and mafenide is capable of exhibiting self-delivery behavior and is found to be effective in biocompatibility, anti-cancer, anti-bacterial, and haemolysis studies.
Colorimetric 3D printable base-detectors exploiting halocromic core-substituted naphthalenediimides
Authors: Tosetto Beatrice , Gastaldi Matteo , Renno Giacomo , Pirri Candido Fabrizio , Barolo Claudia , Fin Andrea , Roppolo Ignazio
Published: February 2023

Naphthalenediimide dye was used to fabricate polymeric 3D printed colorimetric sensors for bases, to detect aqueous, vapor and organic phases.
Tuning ionic conduction and structure stability of ammonium vanadate by intercalating polyaniline molecules for advanced aqueous zinc-ion batteries
Authors: Chen Liming , Zhang Ziqiang , Ma Yu , Wang Yuanming , Xiao Huanhao , Xu Ming , Huang Youyuan , Yuan Guohui
Published: February 2023

Polyaniline is intercalated into NH4V4O10in situ to further enlarge interlayer spacing (13.59 Å) with improving Zn2+diffusion efficient, enhance electronic conductivity (0.001214 S cm−1) and stabilize crystal structure (92.23% over 5000 cycles).
Scale-up synthesis of high-quality solid-state-processed CsCuX (X = Cl, Br, I) perovskite nanocrystal materials toward near-ultraviolet flexible electronic properties
Authors: Jiang Zhi , Liu Hezhuang , Zou Jihua , Huang Yixuan , Xu Zhaoquan , Pustovyi Denys , Vitusevich Svetlana
Published: February 2023

The designed flexible lead-free Cs3Cu2X5 (X = Cl, Br, I) nanocrystal perovskite photodetectors demonstrate excellent properties, including high photoresponses, strong photoselectivity and bending stability at different irradiation wavelengths.
Rhodium-catalyzed selenylation and sulfenylation of quinoxalinones ‘on water’
Authors: Lalji Ram Sunil Kumar , Prince  , Gupta Mohit , Kumar Sandeep , Kumar Amit , Singh Brajendra Kumar
Published: February 2023

‘On-water’ Rh-catalysed, regioselective chalcogenation of 3-phenyl quinoxolinones; its kinetic studies and late-stage functionalisation studies are reported.
Immobilized Cu(0) nanoparticles on montmorillonite-modified with benzalkonium chloride (MMT-BAC@Cu(0)): as an eco-friendly and proficient heterogeneous nano-catalyst for green synthesis of 5-substituted 1H-tetrazoles
Authors: Pirani Fatemeh , Eshghi Hossein , Rounaghi S. Amin
Published: February 2023

An eco-friendly and efficient approach for the synthesis of 2-(1H-tetrazole-5-yl) acrylonitrile derivatives as the preferred product from raw materials through multicomponent domino reactions (MDRs) was introduced.
Adsorption of crystal violet on activated bamboo fiber powder from water: preparation, characterization, kinetics and isotherms
Authors: Sun Shushuang , Zhu Yaming , Gu Zishuo , Chu Hongyu , Hu Chaoshuai , Gao Lijuan , Zhao Xuefei
Published: February 2023

Waste bamboo fiber was obtained from the paper-making industry, and bamboo fiber-activated carbon was prepared by employing the KOH activation method. The bamboo fiber-activated carbon was used as the absorbent to absorb the crystal violet in water.
Fish-like magnetic microrobots for microparts transporting at liquid surfaces
Authors: Wang Lefeng , Zhao Min , He Yuanzhe , Ding Sizhe , Sun Lining
Published: February 2023

Magnetic microrobots have tremendous potential applications due to their wireless actuation and fast response in confined spaces.
Enhanced water-responsive actuation of porous Bombyx mori silk
Authors: Jung Yeojin , Khan Maheen K. , Podbevšek Darjan , Sudhakar Tejaswini , Tu Raymond S. , Chen Xi
Published: February 2023

This study presents the critical role of nanoporous structures in silk's water-responsive actuation and the possibility of controlling and enhancing silk's water-responsive strain and energy density by tuning the nanoporosity.
Single-step growth of p-type 1D Se/2D GeSexOy heterostructures for optoelectronic NO2 gas sensing at room temperature
Authors: Tang Tao , Li Zhong , Cheng Yin Fen , Xu Kai , Xie Hua Guang , Wang Xuan Xing , Hu Xin Yi , Yu Hao , Zhang Bao Yue , Tao Xue Wei , Hung Chu Manh , Hoa Nguyen Duc , Chen Guan Yu , Li Yong Xiang , Ou Jian Zhen
Published: February 2023

One-dimensional (1D)/two-dimensional (2D) heterostructures offer attractive opportunities for developing high-performance gas sensors.
Metal sulfide enhanced metal–organic framework nanoarrays for electrocatalytic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid
Authors: Feng Yixuan , Yang Kun , Smith Richard L. , Qi Xinhua
Published: February 2023

A simple strategy is proposed to fabricate 2D-MOFs embedded with metal sulfide nanoclusters on nickel foam that offered 99% 2,5-furandicarboxylic acid yield with 99% Faraday efficiency for electrochemical oxidation of 5-hydroxymethylfurfural.
Boosting hydrogen evolution through hydrogen spillover promoted by Co-based support effect
Authors: Zhou Ya-Nan , Liu Xin , Yu Cheng-Jie , Dong Bin , Han Guan-Qun , Liu Hai-Jun , Lv Ren-Qing , Liu Bin , Chai Yong-Ming
Published: February 2023

The degree of hydrogen spillover of Pt loaded-samples increased in the sequence of selenides < sulfides < oxides < phosphides, which is contrary to the trend of work function difference between Pt and supports, thus enhancing HER activity in this order.
Understanding the activity of glucose oxidase after exposure to organic solvents
Authors: Dudkaitė Vygailė , Kairys Visvaldas , Bagdžiūnas Gintautas
Published: February 2023

In this work, the effects of apolar, chlorinated, and polar organic solvents on the activity and structure of glucose oxidase were theoretically and experimentally investigated.
Tartaric acid stabilized iridium nanoparticles with excellent laccase-like activity
Authors: Hao Shanhao , Fu Cheng , Zhou Lin , Guo Zhanghong , Song Qijun
Published: February 2023

A schematic illustration of the multi-enzyme activity and application of the Tar-IrNPs nanozyme.
Advanced atomic layer deposition (ALD): controlling the reaction kinetics and nucleation of metal thin films using electric-potential-assisted ALD
Authors: Han Ji Won , Jin Hyun Soo , Kim Yoon Jeong , Heo Ji Sun , Kim Woo-Hee , Ahn Ji-Hoon , Park Tae Joo
Published: February 2023

Electric-potential-assisted atomic layer deposition was demonstrated for Ru film growth. Surface reaction was modified via the electric potential, which affected the nucleation and microstructure of films. Assorted film properties were improved notably.
Modulating room temperature phosphorescence through intermolecular halogen bonding
Authors: Jiang Dongyan , Du Chunya , Yan Zhenyu , Ge Shuyuan , Feng Zijun , Wan Liang , Lu Ping
Published: February 2023

Room temperature phosphorescence materials based on halogenated-morpholine are obtained, wherein the halogen bonding is directly involved in the acceleration of the intersystem crossing and enhancement of solid-state phosphorescence quantum yield.
Yet another perspective on hole interactions, part II: lp-hole vs. lp-hole interactions
Authors: Shukla Rahul , Yu Dongkun , Mu Tiancheng , Kozuch Sebastian
Published: February 2023

lp-holes definitely exist, but do they really interact with nucleophiles to form lp-hole interactions?
Enhancement of C5+selectivity in photothermal Fischer–Tropsch synthesis by an inorganic heteropoly acid catalyst promotor
Authors: Zhang Yichi , Hu Ruijue , Su Haiquan , Su Yue
Published: February 2023

The C5+product selectivity of cobalt-based Fischer–Tropsch synthesis catalyst was significantly improved from 65% to 93% under photothermal conditions by using heteropoly acid (H3PW12O40) as a catalyst promotor.
Insights into the self-assembly of giant polyoxomolybdates from building blocks to supramolecular structures
Authors: Li Ke , Zhu Kai-Ling , Cui Li-Ping , Chen Jia-Jia
Published: February 2023

Gaining an in-depth understanding of the self-assembly mechanism of giant polyoxomolybdates is the key for the designable clusters synthesis. This will in turn promote related supramolecular self-assembly and application research.
Constructing P-doped self-assembled V2C MXene/NiCo-layered double hydroxide hybrids toward advanced lithium storage
Authors: Guo Xi , Li Li , Wang Shuo , Shen Jian , Xu Yanan , Cao Bingqiang
Published: February 2023

The advanced lithium storage performance of the P-doped self-assembled V2C MXene/NiCo-LDH hybrid benefits from high capacitive contribution, high electrical conductivity, and good structural stability.
Cyclotrimetaphosphate-assisted ruthenium catalyst for the hydration of nitriles and oxidation of primary amines to amides under aerobic conditions in water
Authors: Chouhan Kishor Kumar , Chowdhury Deep , Mukherjee Arup
Published: February 2023

A simple ruthenium-based catalytic system is presented for the hydration of nitriles and oxidation of primary amines to amides under ambient conditions in water. Controlled experiments were performed to understand the mechanism.
Complex temperature dependence of the dielectric response in simple SmC* phases
Authors: Jukić Dina , Čepič Mojca
Published: February 2023

In the case of polar smectic liquid crystals, as an example of a soft material, it is shown that what is valid for stable structures cannot be extended to the analysis of dynamics straightforwardly.
Relatively homogeneous network structures of temperature-responsive gels synthesized via atom transfer radical polymerization
Authors: Norioka Chisa , Kawamura Akifumi , Miyata Takashi
Published: February 2023

DLS measurements revealed that temperature-responsive gels prepared by ATRP have more homogeneous networks than those by free radical polymerization. The standard deviation of the scattered intensity is used to quantify the network inhomogeneity.
Building porphyrin-based MOFs on MXenes for ppb-level NO sensing
Authors: Chang Yanwei , Chen Minyi , Fu Zijing , Lu Ruofei , Gao Yixun , Chen Fengjia , Li Hao , Frans de Rooij Nicolaas , Lee Yi-Kuen , Wang Yao , Zhou Guofu
Published: February 2023

Based on the idea of facilitating charge transfer by constructing a Schottky junction, we assembled a porphyrin-based MOF (Co-TCPP(Fe)) with Mxene (Ti3C2Tx) through hydrogen bonding to offer a high-performance chemiresistive NO sensing hybrid.
Acoustic Measures of Dysphonia in Amyotrophic Lateral Sclerosis
Authors: Maffei Marc F. , Green Jordan R. , Murton Olivia , Yunusova Yana , Rowe Hannah P. , Wehbe Farah , Diana Kathleen , Nicholson Katharine , Berry James D. , Connaghan Kathryn P.
Published: February 2023

Purpose:

Identifying efficacious measures to characterize dysphonia in complex neurodegenerative diseases is key to optimal assessment and intervention. This study evaluates the validity and sensitivity of acoustic features of phonatory disruption in amyotrophic lateral sclerosis (ALS).

Method:

Forty-nine individuals with ALS (40–79 years old) were audio-recorded while producing a sustained vowel and continuous speech. Perturbation/noise-based (jitter, shimmer, and harmonics-to-noise ratio) and cepstral/spectral (cepstral peak prominence, low–high spectral ratio, and related features) acoustic measures were extracted. The criterion validity of each measure was assessed using correlations with perceptual voice ratings provided by three speech-language pathologists. Diagnostic accuracy of the acoustic features was evaluated using area-under-the-curve analysis.

Results:

Perturbation/noise-based and cepstral/spectral features extracted from /a/ were significantly correlated with listener ratings of roughness, breathiness, strain, and overall dysphonia. Fewer and smaller correlations between cepstral/spectral measures and perceptual ratings were observed for the continuous speech task, although post hoc analyses revealed stronger correlations in speakers with less perceptually impaired speech. Area-under-the-curve analyses revealed that multiple acoustic features, particularly from the sustained vowel task, adequately differentiated between individuals with ALS with and without perceptually dysphonic voices.

Conclusions:

Our findings support using both perturbation/noise-based and cepstral/spectral measures of sustained /a/ to assess phonatory quality in ALS. Results from the continuous speech task suggest that multisubsystem involvement impacts cepstral/spectral analyses in complex motor speech disorders such as ALS. Further investigation of the validity and sensitivity of cepstral/spectral measures during continuous speech in ALS is warranted.
Reporting of Classroom-Based Morphological Awareness Instruction and Intervention for Kindergarten to Grade 3 Students in the Literature: A Scoping Review
Authors: Passaretti Basiliki , Turkstra Lyn S. , Gallagher Tiffany , Jiang Annie , Cahill Peter , Campbell Wenonah
Published: February 2023

Purpose:

The purpose of this scoping review was to document how the literature reports morphological awareness instruction and interventions delivered by speech-language pathologists (SLPs) and/or educators in classroom settings for kindergarten to Grade 3 students.

Method:

We followed the Joanna Briggs Institute's methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews reporting guidelines. Six relevant databases were searched systematically with article screening and selection completed by two reviewers calibrated for reliability. For data charting, one reviewer extracted content and a second reviewer verified it was pertinent to the review question. Charting for the reported elements of morphological awareness instruction and interventions was guided by the Rehabilitation Treatment Specification System.

Results:

The database search yielded 4,492 records. After removal of duplicates and screening, 47 articles were selected for inclusion. Interrater reliability for source selection exceeded the pre-established criterion of
k
= .61. Our analysis generated a comprehensive description of the elements of morphological awareness instruction as reported in the included articles.

Conclusions:

Our findings provide school-based SLPs and educators a systematic means of reviewing the literature to identify key elements of morphological awareness instruction in published articles for application of evidence-based practices with fidelity, thus helping to close the research-to-practice gap. Our manifest content analysis revealed reporting of the elements for classroom-based morphological awareness instruction was varied, and in some cases, underspecified in the articles included in our study. Implications for clinical practice and future research to advance knowledge and promote implementation of evidence-based practices by SLPs and educators in today's classrooms are discussed.

Supplemental Material:

https://doi.org/10.23641/asha.22105142
Robust state estimation for uncertain linear discrete systems with d‐step measurement delay and deterministic input signals
Authors: Tian Yu , Meng Fanli , Mao Yao , Gao Junwei , Liu Huabo
Published: February 2023

In this study, the state estimation problems for linear discrete systems with uncertain parameters, deterministic input signals and d‐step measurement delay are investigated. A robust state estimator with a similar iterative form and comparable computational complexity to the Kalman filter is derived based on the state augmentation method and the sensitivity penalisation of the innovation process. It is discussed that the steady‐state properties such as boundedness and convergence of the robust state estimator under the assumptions that the system parameters are time invariant. Numerical simulation results show that compared with the Kalman filter, the obtained state estimator is more robust to modelling errors and has nice estimation accuracy.
A rapid prediction model of photovoltaic power generation for autonomous long‐duration aerostat
Authors: Liu Qianshi , Xu Guoning , Li Zhaojie , Gao Yang , Yang YanChu , Li Yongxiang , Du Hao
Published: February 2023

Autonomous long‐duration aerostats (LDA) are one of the most popular research directions of high‐altitude platforms (HAPS) in recent years. Solar photovoltaic (PV) array is the energy source of autonomous long‐duration aerostat, whose power generation predicting accuracy and speed affect the subsequent flight control strategy. Limited by incompleteness cognition of near space, current predicting results cannot meet the requirements of autonomous LDA. In this paper, a novel rapid prediction model of the PV array is proposed. Based on spatial position relation of PV cells, this model can predict the power of single PV cell in any state. The four influence factors including time difference, angle, efficiency loss and temperature are analyzed and optimized comprehensively and innovatively. The new model can be applied in both static state aerostat and dynamic state aerostat. Compared with the traditional model, the efficiency can be improved by 50% and the prediction accuracy can be improved by 10%.
Day‐ahead continuous double auction‐based peer‐to‐peer energy trading platform incorporating trading losses and network utilisation fee
Authors: Liaquat Sheroze , Hussain Tanveer , Celik Berk , Fourney Robert , Hansen Timothy M.
Published: February 2023

Integration of distributed energy resources, such as photovoltaic solar (PV), introduces new opportunities to establish local energy market frameworks to improve renewable energy utilisation in residential sectors. Such peer‐to‐peer (P2P) energy trading refers to a local market structure where customers (and prosumers) interact to share excess PV generation to enhance the individual and community social welfare. In this work, a day‐ahead continuous double auction (CDA)‐based P2P market structure considering network losses and network utilisation fees was designed. Day‐ahead PV energy is modelled using fractional integral polynomials and the output is forecasted using an autoregressive integrated moving average model for each market interval. Based on the customer load and excess PV energy, the CDA market is cleared using a bid/ask matching mechanism. The performance of the P2P market was evaluated by computing different welfare metrics while analysing the effect of network constraints. The results show that the designed CDA‐based P2P market structure increases the social welfare of all participants by an average of 17.75% compared to the baseline for the presented cases. Moreover, the impact of the forecasting error between the day‐ahead and real‐time market was also quantified.
The IACOB project
Authors: Britavskiy N. , Simón-Díaz S. , Holgado G. , Burssens S. , Maíz Apellániz J. , Eldridge J. J. , Nazé Y. , Pantaleoni González M. , Herrero A.
Published: February 2023

Context. The empirical distribution of projected rotational velocities (v sin i) in massive O-type stars is characterised by a dominant slow velocity component and a tail of fast rotators. It has been proposed that binary interaction plays a dominant role in the formation of this tail.

Aims. We perform a complete and homogeneous search for empirical signatures of binarity in a sample of 54 fast-rotating stars with the aim of evaluating this hypothesis. This working sample has been extracted from a larger sample of 415 Galactic O-type stars that covers the full range of v sin i values.

Methods. We used new and archival multi-epoch spectra in order to detect spectroscopic binary systems. We complemented this information with Gaia proper motions and TESS photometric data to aid in the identification of runaway stars and eclipsing binaries, respectively. We also benefitted from additional published information to provide a more complete overview of the empirical properties of our working sample of fast-rotating O-type stars.

Results. The identified fraction of single-lined spectroscopic binary (SB1) systems and apparently single stars among the fast-rotating sample is ∼18% and ∼70%, respectively. The remaining 12% correspond to four secure double-line spectroscopic binaries (SB2) with at least one of the components having a v sin i > 200 km s−1 (∼8%), along with a small sample of 2 stars (∼4%) for which the SB2 classification is doubtful: these could actually be single stars with a remarkable line-profile variability. When comparing these percentages with those corresponding to the slow-rotating sample, we find that our sample of fast rotators is characterised by a slightly larger percentage of SB1 systems (∼18% vs. ∼13%) and a considerably smaller fraction of clearly detected SB2 systems (8% vs. 33%). Overall, there seems to be a clear deficit of spectroscopic binaries (SB1+SB2) among fast-rotating O-type stars (∼26% vs. ∼46%). On the contrary, the fraction of runaway stars is significantly higher in the fast-rotating domain (∼33–50%) than among those stars with v sin i < 200 km s−1. Lastly, almost 65% of the apparently single fast-rotating stars are runaways. As a by-product, we discovered a new over-contact SB2 system (HD 165921) and two fast-rotating SB1 systems (HD 46485 and HD 152200) Also, we propose HD 94024 and HD 12323 (both SB1 systems with a v sin i < 200 km s−1) as candidates for hosting a quiescent stellar-mass black hole.

Conclusions. Our empirical results seem to be in good agreement with the assumption that the tail of fast-rotating O-type stars (with v sin i > 200 km s−1) is mostly populated by post-interaction binary products. In particular, we find that the final statistics of identified spectroscopic binaries and apparent single stars are in good agreement with newly computed predictions obtained with the binary population synthesis code BPASS and earlier estimations obtained in previous studies.
CRIRES+ detection of CO emissions lines and temperature inversions on the dayside of WASP-18b and WASP-76b
Authors: Yan F. , Nortmann L. , Reiners A. , Piskunov N. , Hatzes A. , Seemann U. , Shulyak D. , Lavail A. , Rains A. D. , Cont D. , Rengel M. , Lesjak F. , Nagel E. , Kochukhov O. , Czesla S. , Boldt-Christmas L. , Heiter U. , Smoker J. V. , Rodler F. , Bristow P. , Dorn R. J. , Jung Y. , Marquart T. , Stempels E.
Published: February 2023

The dayside atmospheres of ultra-hot Jupiters (UHJs) are predicted to possess temperature inversion layers with extremely high temperatures at high altitudes. We observed the dayside thermal emission spectra of WASP-18b and WASP-76b with the new CRIRES+ high-resolution spectrograph at near-infrared wavelengths. Using the cross-correlation technique, we detected strong CO emission lines in both planets, which confirms the existence of temperature inversions on their dayside hemispheres. The two planets are the first UHJs orbiting F-type stars with CO emission lines detected; previous detections were mostly for UHJs orbiting A-type stars. Evidence of weak H2O emission signals is also found for both planets. We further applied forward-model retrievals on the detected CO lines and retrieved the temperature-pressure profiles along with the CO volume mixing ratios. The retrieved logarithmic CO mixing ratio of WASP-18b (−2.2−1.5+1.4) is slightly higher than the value predicted by the self-consistent model assuming solar abundance. For WASP-76b, the retrieved CO mixing ratio (−3.6−1.6+1.8) is broadly consistent with the value of solar abundance. In addition, we included the equatorial rotation velocity (υeq) in the retrieval when analyzing the line profile broadening. The obtained υeq is 7.0 ± 2.9 km s−1 for WASP-18b and 5.2−3.0+2.5 km s−1 for WASP-76b, which are consistent with the tidally locked rotational velocities.
Circumplanetary disk ices
Authors: Oberg N. , Cazaux S. , Kamp I. , Bründl T.-M. , Thi W. F. , Immerzeel C.
Published: February 2023

Context. The subsurface oceans of icy satellites are among the most compelling among the potentially habitable environments in our Solar System. The question of whether a liquid subsurface layer can be maintained over geological timescales depends on its chemical composition. The composition of icy satellites is linked to that of the circumplanetary disk (CPD) in which they form. The CPD accretes material from the surrounding circumstellar disk in the vicinity of the planet, however, the degree of chemical inheritance is unclear.

Aims. We aim to investigate the composition of ices in chemically reset or inherited circumplanetary disks to inform interior modeling and the interpretation of in situ measurements of icy solar system satellites, with an emphasis on the Galilean moon system.

Methods. We used the radiation-thermochemical code ProDiMo to produce circumplanetary disk models and then extract the ice composition from time-dependent chemistry, incorporating gas-phase and grain-surface reactions.

Results. The initial sublimation of ices during accretion may result in a CO2 -rich ice composition due to efficient OH formation at high gas densities. In the case of a Jovian CPD, the sublimation of accreted ices results in a CO2 iceline between the present-day orbits of Ganymede and Callisto. Sublimated ammonia ice is destroyed by background radiation while drifting towards the CPD midplane. Liberated nitrogen becomes locked in N2 due to efficient self-shielding, leaving ices depleted of ammonia. A significant ammonia ice component remains only when ices are inherited from the circumstellar disk.

Conclusions. The observed composition of the Galilean moons is consistent with the sublimation of ices during accretion onto the CPD. In this scenario, the Galilean moon ices are nitrogen-poor and CO2 on Callisto is endogenous and primordial. The ice composition is significantly altered after an initial reset of accreted circumstellar ice. The chemical history of the Galilean moons stands in contrast to the Saturnian system, where the composition of the moons corresponds more closely with the directly inherited circumstellar disk material.
AF Lep b: The lowest-mass planet detected by coupling astrometric and direct imaging data
Authors: Mesa D. , Gratton R. , Kervella P. , Bonavita M. , Desidera S. , D’Orazi V. , Marino S. , Zurlo A. , Rigliaco E.
Published: February 2023

Aims. Using the direct-imaging technique, we searched for low-mass companions around the star AF Lep, which presents a significant proper-motion anomaly (PMa) signal obtained from the comparison of HIPPARCOS and Gaia eDR3 catalogs.

Methods. We observed AF Lep in two epochs with VLT/SPHERE using its subsystems IFS and IRDIS in the near-infrared, covering wavelengths ranging from the Y to the K spectral bands (between 0.95 and 2.3 μm). We then reduced the data using the high-contrast imaging techniques angular differential imaging (ADI) and spectral differential imaging in order to be able to retrieve the signal from low-mass companions of the star.

Results. A faint companion was retrieved at a separation of ~0.335″ from the star and with a position angle of ~70.5° in the first epoch and with a similar position in the second epoch. This corresponds to a projected separation of ~9 au. The extracted photometry allowed us to estimate a mass for the companion of between 2 and 5 MJup. This mass is in good agreement with astrometric measurements of the dynamic mass of the companion, which give 5.2–5.5 MJup. This is the first companion with a mass well below the deuterium burning limit that was discovered by coupling direct imaging with PMa measurements. Orbital fitting done using the orvara tool allowed us to further confirm the companion mass and to define its main orbital parameters.
Zwicker’s Loudness model as a robust calculation method for assessment of adequacy of airborne sound insulation descriptors for partition walls in dwelling houses
Authors: Rychtáriková Monika , Zelem Lukáš , Chmelík Vojtech , Bailhache Simon , Glorieux Christ
Published: February 2023

The development and validation of single number quantities that are meant to serve for straightforward assessment and comparison of airborne sound insulation properties of partition walls are typically challenged by the necessity to perform large numbers of laboratory listening tests with human subjects. This is because a reliable validation of a single number quantity requires testing for many different wall types with multiple real-life stimuli that are representative for daily life soundscapes. In this article, an alternative approach is presented that allows to test a large number of “partition wall – real-life sound stimuli” combinations. This approach uses the well-established and nowadays generally accepted Zwicker’s Loudness for quantifying the subjective loudness of sound passing through a wall, and derive from that the subjectively perceived sound insulation. Using the proposed assessment method, the adequacy of single number quantities that are currently in use, and a number of newly proposed single number quantities, are compared.
Comparison of structural heterogeneity in Zr- and Pd-based metallic glasses
Authors: Wang Hao , Zhu Sheng-Li , Cui Zhen-duo
Published: February 2023

Metallic glasses (MGs) are known to exhibit a nanoscale heterogeneous structure that consists of a weakly bonded region (WBR) and a strongly bonded region (SBR), but its characterization is not yet fully understood. This study investigates the structural heterogeneity of Zr- and Pd-based MGs using a dynamic viscoelastic model. Volume fraction (V) and elastic modulus (Ec) are independently derived from the model to characterize each region. In addition, the structural heterogeneity is evaluated using χ = VEc,WBR/VEc,total. As a result, the strong Zr-based MG is estimated to own approximately 28% of VWBR, approximately 87% of Ec,WBR/Ec,SBR, and χ ∼ 0.241. On the other hand, the fragile Pd-based MG is estimated to own approximately 26% of VWBR, approximately 70% of Ec,WBR/Ec,SBR, and χ ∼ 0.208. Furthermore, a comparison of χ, fragility, and Poisson's ratio shows that as χ increases, fragility decreases and Poisson's ratio increases. Notably, the diversification of constituent elements is inversely related to χ, fragility, and Poisson's ratio in the Zr- and Pd-based MGs. Thus, the existing understanding of the structural heterogeneity inherent in MGs is updated using the constructed dynamic viscoelastic model in this study.
Un paysage fétichique
Authors: Dock Samuel
Published: February 2023

Dans cet article l’auteur présente le cas d’Edouard, un fétichiste de 45 ans. Il explique pourquoi il est plus pertinent de parler de « paysage fétichique » que de « scène perverse » et soulève les enjeux éthiques d’un tel choix en s’appuyant sur l’œuvre de Georges Lanteri-Laura.
Cannabis – was wirkt wie?
Authors: Melzig Matthias F.
Published: February 2023

Cannabis, genauer die oberirdischen Pflanzenteile, v. a. Triebspitzen und
Blüten der weiblichen Pflanze von Cannabis sativa L., enthalten mehr
als 500 Verbindungen, von denen mindestens 100 als Cannabinoide bzw.
Phytocannabinoide bekannt sind. Weitere Sekundärstoffe sind Flavonoide und
Terpene.
Gesunder Schlaf durch Hydrotherapie nach Kneipp
Authors: Gündling Peter W.
Published: February 2023

Schlafstörungen sind ein recht häufiges Problem in der täglichen Praxis, über das insbesondere ältere Menschen klagen. Nicht zuletzt aufgrund möglicher Nebenwirkungen und der Gefahr der Gewöhnung oder gar Abhängigkeit sollten vor der Verordnung von Schlafmitteln nichtmedikamentöse Verfahren zum Einsatz kommen. Einige bewährte Verfahren wie kalte Abwaschungen oder warme Fußbäder entstammen der Kneipp’schen Hydrotherapie, deren Durchführung und Wirkung, aber auch wissenschaftliche Evidenz Gegenstand dieses Beitrags sind.
Rechtskolumne: Mehr Sicherheit bei der NUB-Abrechnung
Authors: Rybak Christian
Published: February 2023

Die Erstattung von neuen Untersuchungs- und Behandlungsmethoden (NUB) folgt im stationären Sektor dem Grundsatz „Erlaubnis mit Verbotsvorbehalt“. Danach sind NUB grundsätzlich erstattungsfähig, solange keine negative Entscheidung des Gemeinsamen Bundesausschusses (G-BA) vorliegt.
Finanzierung: Pflegebudget als Chance nutzen
Authors: Mehmecke Sandra
Published: February 2023

Mit dem Pflegepersonal-Stärkungsgesetz wurden die Personalkosten des Pflegedienstes aus den Fallpauschalen ausgegliedert. Was seitdem passiert ist, und wie es weitergehen könnte.