bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovative Mind–Body Intervention Day Easy Exercise Increases Peripheral Blood CD34+ Cells in Adults
Authors: Wu Ting-Yi , Kung Chia-Chi , Kao Ting-Yu , Sun Wei-Hsin
Published: August 2020

Mind–body interventions (MBIs) have many health benefits, such as reducing stress, modulating blood pressure, and improving sleep and life quality. The long-term practice of Tai chi, an MBI, also increases the number of CD34+ cells, which are surface markers of hematopoietic stem cells, so prolonged Tai chi practice may have antiaging effects. We developed the day easy exercise (DEE), an innovative MBI, that is easy to learn and requires only a small exercise area and a short practice time. The aim of this study was to explore whether DEE, like Tai chi, has antiaging effects after short-term practice. Total 44 individuals (25 to 62 years old) with or without 3-month DEE practice were divided into young- and middle-aged groups (≤30 and >30 years old) and peripheral blood was collected at 0, 1, 2, and 3 months for analysis of CD34+ cells. The number of CD34+ cells in peripheral blood remained unchanged in control young- and middle-aged groups. After DEE, the number of CD34+ cells in peripheral blood was increased over time in both young- and middle-aged groups. For young-aged adults, the cell number was markedly increased by threefold at 3 months after DEE, and for middle-aged adults, the increase was significant from the first month. DEE practice indeed increased the number of CD34+ cells in peripheral blood and the increase was more significant for older people in a shorter time. This is the first study to provide evidence that the DEE may have antiaging effects and could be beneficial for older people.
Depictions of deception: A corpus-based analysis of five Shakespearean characters
Authors: Archer Dawn , Gillings Mathew
Published: August 2020

Drawing on the Enhanced Shakespearean Corpus: First Folio Plus and using corpus-based methods, this article explores, quantitatively and qualitatively, Shakespeare’s depictions of five deceptive characters (Aaron, Tamora, Iago, Lady Macbeth and Falstaff). Our analysis adopts three strands: firstly, statistical keywords relating to each character are examined to determine what this tells us about their natures more generally. Secondly, the wordlists produced for each of the five characters are drawn upon to determine the extent to which they make use of linguistic features that have been correlated with, or linked to, acts of deliberate deception in real-world contexts. Thirdly, we make use of the results identified during the two aforementioned strands by using them to identify particular (sequences of) turns that are worthy of more detailed analysis. Here, we are primarily interested in (a) whether these keywords/deceptive indicators cluster or co-occur and (b) whether these interactions are the same as those identified by other scholars exploring depictions of deception in Shakespeare from a literary perspective. The findings indicate that deception-related features are indeed used collectively/in close proximity, by Shakespeare, at points where a character speaks to other characters disingenuously. They also suggest that Shakespeare’s deceptive depictions do change stylistically, from character to character, in line with those characters’ different characterisations and situations, that Shakespeare draws on atypical language features – such as self-oriented references – when it comes to some of his depictions of deception and that Shakespeare uses these various stylistic features to achieve a range of dramatic effect(s).
Breast cancer overdiagnosis in stop-screen trials: More uncertainty than previously reported
Authors: Baker Stuart G , Prorok Philip C
Published: August 2020

Objective

According to the Independent UK Panel on Breast Cancer Screening, the most reliable estimates of overdiagnosis for breast cancer screening come from stop-screen trials Canada 1, Canada 2, and Malmo. The screen-interval overdiagnosis fraction is the fraction of cancers in a screening program that are overdiagnosed. We used the cumulative incidence method to estimate screen-interval overdiagnosis fraction. Our goal was to derive confidence intervals for estimated screen-interval overdiagnosis fraction and adjust for refusers in these trials.

Methods

We first show that the UK Panel’s use of a 95% binomial confidence interval for estimated screen-interval overdiagnosis fraction was incorrect. We then derive a correct 95% binomial-Poisson confidence interval. We also use the method of latent-class instrumental variables to adjust for refusers.

Results

For the Canada 1 trial, the estimated screen-interval overdiagnosis fraction was 0.23 with a 95% binomial confidence interval of (0.18, 0.27) and a 95% binomial-Poisson confidence interval of (0.04, 0.41). For the Canada 2 trial, the estimated screen-interval overdiagnosis fraction was 0.16 with a 95% binomial confidence interval of (0.12, 0.19) and a 95% binomial-Poisson confidence interval of (−0.01, 0.32). For the Malmo trial, the estimated screen-interval overdiagnosis fraction was 0.19 with a 95% binomial confidence interval of (0.15, 0.22). Adjusting for refusers, the estimated screen-interval overdiagnosis fraction was 0.26 with a 95% binomial-Poisson confidence interval of (0.03, 0.50).

Conclusion

The correct 95% binomial-Poisson confidence interval s for the estimated screen-interval overdiagnosis fraction based on the Canada 1, Canada 2, and Malmo stop-screen trials are much wider than the previously reported incorrect 95% binomial confidence intervals. The 95% binomial-Poisson confidence intervals widen as follow-up time increases, an unappreciated downside of longer follow-up in stop-screen trials.
Suppression of robot vibrations using input shaping and learning-based structural models
Authors: Newman Michael , Lu Kaiyue , Khoshdarregi Matt
Published: August 2020

Industrial robots used in manufacturing processes such as drilling of aerospace structures undergo many rapid positioning motions during each operation. Such aggressive motions excite the structural modes of the robot and cause inertial vibrations at the end-effector, which may damage the part and violate the tolerance requirements. This article presents a vibration avoidance technique based on input shaping combined with a learning-based structural dynamic model. A theoretical dynamic model is first developed for commonly used robotic arms considering the flexibilities of the first three joints of the robot. An artificial neural network is developed and used in conjunction with the dynamic model to predict the natural frequency of the system at any pose in the workspace. Transfer learning techniques are used to extend the trained artificial neural network to account for the mass of the payload with minimal data collection. To reduce the residual vibrations of the robot in rapid motions, zero-vibration derivative shapers are designed and implemented. The effectiveness of the presented methodology has been validated experimentally on a Staubli RX90CR robot with an open-architecture control system developed fully in-house. Experimental results show more than 85% reduction in residual vibrations during aggressive motions of the robot.
Indigenous Teacher Education Is Nation Building: Reflections of Capacity Building and Capacity Strengthening in Idaho
Authors: Anthony-Stevens Vanessa , Mahfouz Julia , Bisbee Yolanda
Published: August 2020

This article discusses the efforts of the Indigenous Knowledge for Effective Education Program (IKEEP), at the University of Idaho, a predominately white institution (PWI) of higher education, and its struggle to create space in higher education for intentional support of Indigenous self-determination, sovereignty, and Tribal nation building through the preparation of Indigenous teachers. In doing so, we examine the contentious and local work of reimagining education, from the bottom up and top down, to develop leaders to serve the needs of Indigenous youth and communities through the vehicle of mainstream institutions. With data from a multiyear ethnographic documentation, we examine the experiences of IKEEP program administration, teacher mentors, and students through the conceptual lens of Tribal nation building in higher education. Our findings underscore how teacher education programs at PWIs need to engage in a radical shift toward seeing Indigenous teachers as nation builders and to prioritize the infrastructure and programmatic collaboration to support them and their communities as such.
Comparative Study of Presurgical Infant Orthopedics by Modified Grayson Method and Dynacleft With Nasal Elevators in Patients With Unilateral Cleft Lip and Palate—A Clinical Prospective Study
Authors: Abhinav B. A. , Batra Puneet , Chander Sood Sundereshwer , Sharma Karan , Srivastava Amit , Raghavan Sreevatsan
Published: August 2020

Objective:

To compare the effects of presurgical infant orthopedics using 2 different methods, that is, the Dynacleft with Nasal elevator system versus the modified Grayson’s technique in patients with complete unilateral cleft lip and palate.

Design:

Prospective comparative cohort study.

Materials and Methods:

Twenty-eight patients were divided into 2 groups, that is, Group A consisting of 14 patients who underwent correction with DynaCleft with Nasal elevator system and Group B consisting of 14 patients undergoing correction using the modified Grayson technique. Maxillary cast measurements were taken at 2-time intervals (pre- and posttreatment) to assess various parameters using a laser scanning machine (C500 Solutionix) and 3D software (GOM Inspect). Similarly, standardized anterior–posterior and worm’s-eye view photographs using a custom box were taken and imported to Adobe Photoshop CS6 for measurements. Paired t test and independent t test were used to compare intra- and intergroup changes, respectively.

Results:

The analysis of cast (primary outcome) and photographic (secondary outcome) measurements showed improved nasal asymmetry and alveolar correction in both groups which showed no significant intergroup difference when assessed using the independent t test ( P > .05). Group A showed higher chances (42.8%) of causing a T-shaped defect (due to excessive mesial-inward rotation of the minor segment) when compared to the Group B possibly due to a more controlled molding vector ( P < .05).

Conclusion:

Both methods proved effective in improving the nasal asymmetry, reducing the alveolar cleft gap, and approximating the lips together; but care must be taken when applying the alveolar molding vector in the Dynacleft system.
Sociodemographic Predictors of Treatment Success and Difficulty in Nasoalveolar Molding
Authors: Gibson Travis L. , Grayson Barry H. , Shetye Pradip R.
Published: August 2020

Objective:

To assess social and demographic influences on caregiver success and difficulty with nasoalveolar molding (NAM).

Design:

Retrospective review identified patients who began NAM between April 22, 2013, and April 18, 2017, at the New York University Langone Medical Center. Records were reviewed, and the following sociodemographic data retrieved: parental marital status, parental ages, number of siblings, distance traveled to clinic, insurance coverage, concurrent medical conditions, and need for an interpreter.

Patients:

Patients were included if complete charting was available; 106 patients met the inclusion criteria; 79 patients with unilateral and 27 with bilateral clefts.

Outcome Measures:

Chart entries indicating incorrect appliance usage, emergency visits, phone calls, and noncompliance were recorded. Alveolar cleft gap closure was measured on pre- and posttreatment models in unilateral cases. Multiple regression analyses were performed to assess the influence of social variables on these outcomes.

Results:

Alveolar cleft gap closure was 7.2 ± 3.0 mm, or 78.5% ± 19.1%. Cleft closure increased with paternal age by 0.33 mm ( P = .007) or 2.0% ( P = .017) per year, decreased with maternal age by 0.29 mm ( P = .041) per year, and increased in married and partnered parents by 39% ( P = .018). Incorrect appliance usage averaged 0.62 fewer instances for married and partnered parents ( P = .018) and 0.43 fewer for those with private insurance ( P = .019).

Conclusions:

Alveolar cleft gap closure was more successful for older fathers, younger mothers, and married couples. Married couples were also less likely to experience treatment difficulties such as incorrect appliance usage or inadequate duration of wear, as were those with private insurance coverage.
The Role of Natriuretic Peptides in the Regulation of Cardiac Tolerance to Ischemia/Reperfusion and Postinfarction Heart Remodeling
Authors: Krylatov Andrey V. , Tsibulnikov Sergey Y. , Mukhomedzyanov Alexander V. , Boshchenko Alla A. , Goldberg Victor E. , Jaggi Amteshwar S. , Erben Reinhold G. , Maslov Leonid N.
Published: August 2020

In the past 10 years, mortality from acute myocardial infarction has not decreased despite the widespread introduction of percutaneous coronary intervention. The reason for this situation is the absence in clinical practice of drugs capable of preventing reperfusion injury of the heart with high efficiency. In this regard, noteworthy natriuretic peptides (NPs) which have the infarct-limiting effect, prevent reperfusion cardiac injury, prevent adverse post-infarction remodeling of the heart. Atrial natriuretic peptide does not have the infarct-reducing effect in rats with alloxan-induced diabetes mellitus. NPs have the anti-apoptotic and anti-inflammatory effects. There is indirect evidence that NPs inhibit pyroptosis and autophagy. Published data indicate that NPs inhibit reactive oxygen species production in cardiomyocytes, aorta, heart, kidney and the endothelial cells. NPs can suppress aldosterone, angiotensin II, endothelin-1 synthesize and secretion. NPs inhibit the effects aldosterone, angiotensin II on the post-receptor level through intracellular signaling events. NPs activate guanylyl cyclase, protein kinase G and protein kinase A, and reduce phosphodiesterase 3 activity. NO-synthase and soluble guanylyl cyclase are involved in the cardioprotective effect of NPs. The cardioprotective effect of natriuretic peptides is mediated via activation of kinases (AMPK, PKC, PI3 K, ERK1/2, p70s6 k, Akt) and inhibition of glycogen synthase kinase 3β. The cardioprotective effect of NPs is mediated via sarcolemmal KATP channel and mitochondrial KATP channel opening. The cardioprotective effect of brain natriuretic peptide is mediated via MPT pore closing. The anti-fibrotic effect of NPs may be mediated through inhibition TGF-β1 expression. Natriuretic peptides can inhibit NF-κB activity and activate GATA. Hemeoxygenase-1 and peroxisome proliferator-activated receptor γ may be involved in the infarct-reducing effect of NPs. NPs exhibit the infarct-limiting effect in patients with acute myocardial infarction. NPs prevent post-infarction remodeling of the heart. To finally resolve the question of the feasibility of using NPs in AMI, a multicenter, randomized, blind, placebo-controlled study is needed to assess the effect of NPs on the mortality of patients after AMI.
Examining the Use, Perception, and Motivation of Cord-Cutting: A Consumer Segment Approach
Authors: Kim Hun , Chan-Olmsted Sylvia M. , Hwang Kyung-Ho , Chang Byeng-Hee
Published: August 2020

This study investigates the factors affecting the cord-cutting behavior of media consumers. Adopting the frameworks of diffusion of innovations, uses and gratifications theory (U&G), channel repertoire, and media usage/segmentation, we conducted an online survey of 860 respondents in the United States to examine the use, perception, and motivation of cord-cutting behavior among three different consumer segments: cord-cutters, cord-loyalists, and cord-couplers. The results show that cord-cutting is predicted by eudaimonic and exploration motivators, perceived compatibility and complementarity, and age.
Validation Repertories of Media Audiences in the Digital Age: Examining the Legitimate Authority of Cultural Mediators
Authors: Verboord Marc
Published: August 2020

This article contributes to the study of legitimate authority and symbolic power in the media field by analyzing what I call the “validation repertoires” of audiences, that is, the various ways individuals combine in a single set of beliefs separate judgments of how valid or worthwhile they regard the opinions of a media worker with a specific institutionalized background. The empirical analysis focuses on cultural mediators and has three aspects: (a) mapping repertoires via latent class analysis, (b) explaining adherence to repertoires by links to positions in the field, and (c) predicting how repertoires affect the concrete use of recommendation systems. The results show that, currently, validation repertoires are mainly organized according to the degree of validation, not the degree of institutionalization; the validation of mediators appears to be multifaceted, influenced by cultural and media-related resources and generalized institutional trust; and repertoires have an impact on choice behavior.
Factors associated with positive urine cultures in cats with subcutaneous ureteral bypass system implantation
Authors: Pennington Catrina E , Halfacree Zoe , Colville-Hyde Charlotte , Geddes Rebecca F
Published: August 2020

Objectives

The aims of this study were to report the postoperative incidence of subcutaneous ureteral bypass (SUB)-associated bacteriuria and risk factors in a large population of UK cats, to identify the commonly implicated isolates in these cases and to report associations of positive postoperative urine cultures with device occlusion or a need for further surgery.

Methods

Electronic clinical records were reviewed to identify cats with ureteral obstruction that underwent unilateral or bilateral SUB implantation between September 2011 and September 2019. In total, 118 client-owned cats were included in the study population. Information recorded included signalment, history, surgical and biochemical factors, urinalysis and culture results. Multivariable logistic regression was performed to identify variables associated with a positive postoperative culture.

Results

In total, 10 cats (8.5%) had a positive postoperative culture within 1 month postsurgery and 28 cats (23.7%) within 1 year postsurgery. Cats with a positive preoperative culture were significantly more likely to have a positive culture within 6 months postoperatively (odds ratio [OR] 4.09, 95% confidence interval [CI] 1.18–14.18; P = 0.026). Of the 14 cats with a positive preoperative culture, six (42.9%) returned a positive culture within 1 year postoperatively, and in four cases (66.7%) the same isolate was identified. Cats with a higher end-anaesthetic rectal temperature were significantly less likely to return a positive culture within 3 months (OR 0.398, 95% CI 0.205–0.772; P = 0.006) postsurgery. Cats culturing positive for Escherichia coli at any time point (OR 4.542, 95% CI 1.485–13.89; P = 0.008) were significantly more likely to have their implant removed or replaced.

Conclusions and relevance

Perioperative hypothermia and preoperative positive culture were independent predictors of a postoperative positive culture and this should be taken into consideration when managing these cases. Positive postoperative culture rates were higher than have previously been reported.
Effects of the first month of lockdown for COVID-19 in Italy: A preliminary analysis on the eyecare system from six centers
Authors: dell’Omo Roberto , Filippelli Mariaelena , Semeraro Francesco , Avitabile Teresio , Giansanti Fabrizio , Parmeggiani Francesco , Romano Mario R , Strianese Diego , Romano Vito , Virgili Gianni , Costagliola Ciro
Published: August 2020

Purpose:

To compare the number of eye surgical procedures performed in Italy during the first month of lockdown with those performed in the same period in 2019.

Methods:

Review of the surgical procedures performed from 10 March to 9 April 2019 and from 10 March to 9 April 2020 (the first month of lockdown because of the COVID-19 outbreak) at six academic institutional centers of Italy. A distinction was made between urgent procedures: any trauma repairment, trabeculectomy/drainage implant for glaucoma, any operation for rhegmatogenous retinal detachment (RRD) repair, pars plana vitrectomy (PPV) for vitreous hemorrhage (VH), macular hole, or retained lens fragments; elective procedures: corneal transplant, phacoemulsification for cataract extraction, silicone oil removal, and PPV for epiretinal membrane; and intravitreal injections (either anti-vascular endothelial growth factor [VEGF] or dexamethasone) to treat exudative maculopathies. The main outcome measure was the rate of reduction in urgent and elective surgeries performed.

Results:

Overall, 3624 and 844 surgical procedures were performed from 10 March to 9 April 2019 and from 10 March to 10 April 2020, respectively (−76.7% in 2020 compared to 2019, p < 0.0001). Urgent and elective surgical procedures and intravitreal injections of anti-VEGF drugs or dexamethasone reduced significantly in 2020 in comparison to 2019 ( p < 0.0001 for urgent and elective surgeries and 0.01 for intravitreal injections).

Conclusion:

A significant reduction in the rate of urgent and elective surgeries and intravitreal injections was recorded during the first month of lockdown compared to the same period in 2019. With this analysis, the authors hope to provide some preliminary insights about the consequences of lockdown for the eyecare system in Italy.
Carotid Plaque Morphology is Similar in Patients with Reduced and Normal Renal Function
Authors: Heijl Caroline , Kahn Fredrik , Edsfeldt Andreas , Tengryd Christoffer , Nilsson Jan , Goncalves Isabel
Published: August 2020

Background:

Chronic Kidney Disease (CKD) is associated with an increased risk for cardiovascular events such as stroke. However, it is still unclear if decreased kidney function is associated with a vulnerable atherosclerotic plaque phenotype. To explore if renal function was associated with carotid plaque vulnerability we analyzed carotid plaques obtained at surgery from the Carotid Plaque Imaging Project (CPIP).

Methods:

Patients were enrolled through the CPIP cohort. The indication for surgery was plaques with stenosis >70%, associated with ipsilateral symptoms or plaques with stenosis >80% not associated with symptoms. Transversal sections from the most stenotic plaque region were analyzed for connective tissue, calcium, lipids, macrophages, intraplaque hemorrhage, and smooth muscle cells. Homogenates were analyzed for collagen and elastin.

Results:

Carotid endarterectomy specimens from 379 patients were obtained. The median GFR was 73 ml/min/1.73 m2. Plaque characteristics showed no significant association with eGFR, neither when eGFR was divided in CKD groups nor when eGFR was handled as a continuous variable and adjusting for other known risk factors (ie, age, diabetes, hypertension, and smoking).

Conclusions:

The higher risk of cardiovascular disease such as stroke in CKD is not associated with increased plaque vulnerability and other factors have to be sought.
Genetic Heterogeneity Between Paired Primary and Brain Metastases in Lung Adenocarcinoma
Authors: Li Li , Liu Zhulin , Han Rui , Li Lin , Wang Mengyao , Huang Depei , He Yong
Published: August 2020

Purpose:

About one-third of nonsmall cell lung cancer (NSCLC) patients develop brain metastases (BM). However, there is an unmet need for early diagnosis and treatment of BM. The precise mechanism for BM is still unknown. However, the genetic heterogeneity between primary tumor and paired BM indicates that sampling from the primary tumor may not be able to fully represent the mutational status in metastases. In this study, the genetic heterogeneity of primary lung adenocarcinoma and paired BM was analyzed.

Patients and methods:

A total of 11 paired samples of primary tumors and BM from lung cancer patients were included, in which 7 paired samples of patients were finally analyzed. Samples were sequenced by whole-exome sequencing (WES) to investigate the common and unique mutations in the primary tumors and BM, and the similarities and differences in copy number variation (CNV).

Results:

The consistency of gene mutation between primary lung adenocarcinoma and paired BM was 33% to 86%. FAM129C and ADAMTSs specifically mutated in BM, along with NKX2-1 high amplification and SAMD2/4 copy number deletion.

Conclusion:

The consistency of gene mutation between primary lung adenocarcinoma and corresponding BM is relatively high, while the individual differences were significant. FAM129C and ADAMTSs mutations and high amplification of NKX2-1 may be related to BM of lung cancer. The loss of copy number of SAMD2/4 may be a potential therapeutic target for BM from lung adenocarcinoma.
“I did not know what to expect”: Music as a means to achieving work-life balance
Authors: Joseph Dawn
Published: August 2020

Work–life balance has become a buzzword in many corporate settings. This study situates itself at a higher education institute in Melbourne (Australia) where African music (singing and drumming) was used as a lever for faculty staff to “break from work” and “learn about a new music and culture”. Drawing on email communication, questionnaire data, and anecdotal feedback, a phenomenological approach was adopted to explore the benefits, challenges, and opportunities staff experienced as a recreational group music activity. Data were analyzed using interpretative phenomenological analysis as a tool. Two overarching themes emerged (group participation and learning, and challenges) and are discussed in the findings. The workshops proved successful and are worthy to be replicated in other places and spaces. Further research is needed to gain insight into whether regular music workshops can influence work–life balance and professional learning for staff.
Spontaneous singing in early childhood: An examination of young children’s singing at home
Authors: Dean Bronya
Published: August 2020

Spontaneous singing is widely acknowledged as an important part of young children’s everyday musical experience. However, its fleeting and often private nature makes it difficult to study. Research into young children’s singing at home frequently relies on data gathered through parental reporting, and studies are often limited to small sample sizes. In this article, I explore the nature, extent and contexts of spontaneous singing among 15 three- and four-year-old children at home. Continuous audio recording was used to collect naturalistic data during the children’s normal everyday routines. This innovative method resulted in data that could be analysed quantitatively to provide a comprehensive overview of spontaneous singing in young children’s everyday home lives that has so far been missing from the literature. Analysis showed that all the children sang spontaneously. The singing behaviours they displayed were similar to those described in the literature, but contrary to some of the literature, the most prevalent singing behaviours were improvisatory. Spontaneous singing occurred during many everyday activities; however, the strongest influence on singing was found to be the social context in which it took place. The children used different ways of singing when interacting socially or when playing on their own, with most singing occurring when children were on their own, potentially unnoticed by adults.
Fostering singing agency through emotional differentiation in an inclusive singing environment
Authors: Hogle Lauri A
Published: August 2020

The purpose of this phenomenological study was to gain insight into experiences of adults who expressed personal discomfort with singing, either alone or when others might hear them. Singing agency in music learning, one’s belief in one’s own capacity to sing aloud, served as the guiding lens for the study. Narrative analysis of interview data, from 15 adults who self-identified as non-singers, provided understanding of experiences that they believed undermined their capacity for singing agency. Four initial themes emerged as participants described wounding incidents with resultant perceptions of deficit, disability, and shame; personal strategies to enhance or protect singing agency; perceived obstacles to singing agency; and personal definitions of good singing. Findings describe vocal skill development through emotional differentiation, linking singing agency with principles that underlie a social constructivist approach to music learning and teaching and a Universal Design for Learning.
Autologous hematopoietic stem cell transplantation following alemtuzumab therapy in aggressive multiple sclerosis: A report of three cases
Authors: Boffa Giacomo , Sbragia Elvira , Raiola Anna Maria , Varaldo Riccardo , Capello Elisabetta , Gallo Paolo , Granella Franco , Mancardi Gianluigi , Inglese Matilde
Published: August 2020

The management of multiple sclerosis patients with persistent disease activity under alemtuzumab treatment is not established yet. Concerns have been raised on the safety of autologous haematopoietic stem cell transplantation (aHSCT) after alemtuzumab treatment because of the risk of serious infectious adverse events. We report short-term safety and efficacy data from three patients treated with aHSCT following alemtuzumab treatment. Early adverse events were consistent with expected transplant toxicities. All patients were free of disease activity at the last follow-up. Our data suggest that aHSCT can be considered as a rescue treatment strategy for MS patients with persistent disease activity during alemtuzumab treatment.
Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease
Authors: Duscha Brian D , Kraus William E , Jones William S , Robbins Jennifer L , Piner Lucy W , Huffman Kim M , Allen Jason D , Annex Brian H
Published: August 2020

Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen delivery. This cross-sectional study tested the hypothesis that capillary density is related to claudication times and anaerobic threshold (AT) in patients with PAD. A total of 37 patients with PAD and 29 control subjects performed cardiopulmonary exercise testing on a treadmill for AT and gastrocnemius muscle biopsies. Skeletal muscle capillary density was measured using immunofluorescence staining. PAD had decreased capillary density (278 ± 87 vs 331 ± 86 endothelial cells/mm2, p = 0.05), peak VO2 (15.7 ± 3.9 vs 24.3 ± 5.2 mL/kg/min, p ⩽ 0.001), and VO2 at AT (11.5 ± 2.6 vs 16.1 ± 2.8 mL/kg/min, p ⩽ 0.001) compared to control subjects. In patients with PAD, but not control subjects, capillary density was related to VO2 at AT ( r = 0.343; p = 0.038), time to AT ( r = 0.381; p = 0.020), and time after AT to test termination ( r = 0.610; p ⩽ 0.001). Capillary density was also related to time to claudication ( r = 0.332; p = 0.038) and time after claudication to test termination ( r = 0.584; p ⩽ 0.001). In conclusion, relationships between capillary density, AT, and claudication symptoms indicate that, in PAD, exercise limitations are likely partially dependent on limited skeletal muscle capillary density and oxidative metabolism.
Making fluency research accessible to second language teachers: The impact of a training intervention
Authors: Tavakoli Parvaneh
Published: August 2020

The study reported in this article was aimed at investigating whether making the findings of second language fluency research accessible to language teachers has an impact on their self-reported understanding of the concept of oral fluency, confidence in promoting it, and classroom practice in short and medium term. The data come from 106 initial and 32 delayed questionnaires, eliciting both qualitative and quantitative data, from second language teachers in England after attending a one-day research-informed and practice-oriented training workshop. The results indicate a positive impact of the intervention on teachers’ understanding of fluency, confidence in helping their learners, and self-reported practice in short term, with the impact being reported 10–12 weeks after the intervention. The findings imply that adopting a narrow perspective to defining and conceptualizing fluency is linked with a more in-depth understanding of fluency and enhanced confidence and ability for using fluency-focused classroom activities.
Using the Cultural Formulation Interview in Denmark: Acceptability and clinical utility for medical doctors and migrant patients
Authors: Skammeritz Signe , Lindberg Laura Glahder , Mortensen Erik Lykke , Norredam Marie , Carlsson Jessica
Published: August 2020

Previous studies have shown the importance of focusing on the cultural background of migrant patients in the psychiatric assessment. The Cultural Formulation Interview (CFI) offers a patient-focused approach to foreground the cultural context of the patient in the clinical encounter. Our objective was to explore the acceptability and clinical utility of the CFI for physicians and its acceptability for migrant patients seen at a transcultural mental health clinic in Denmark. In this study, the CFI was used in a second session following the standard clinical assessment to explore what additional information was gained from the CFI. Data on the use of the CFI data were collected immediately after the interview with questionnaires for medical doctors (MDs) ( N = 12) and patients ( N = 71). The findings showed that the CFI, in addition to standard assessment, was useful to the MDs for planning the treatment (60.0%) and for exploring the patients’ view on their cultural and social context (74.7%), but less so for the diagnostic process (9.9%). Patients reported high overall satisfaction with the CFI (93.0%) and viewed it as a welcome opportunity to tell their story. The findings add to existing knowledge on the CFI in terms of acceptability for patients of a primarily Middle Eastern origin and patients using an interpreter during the CFI session. Based on the findings of this study, the CFI is recommended to clinicians for treatment planning purposes and for exploring the cultural and social context of the patient.
Registered intermediaries’ assessment of children’s communication: An exploration of aims and processes
Authors: Collins Kimberly , Krahenbuhl Sarah
Published: August 2020

Following the implementation of the Youth Justice and Criminal Evidence Act 1999 for England and Wales, Registered Intermediaries have been available to assist child witness communication in legal proceedings since 2004. Registered Intermediaries are given training to fulfil this role. However, their assessments and practices are conducted independently. This study examined Registered Intermediaries’ perceptions and experiences of this independent practice, and the impact this had on the quality of the legal process in terms of evidential quality, child witness experiences and engagement. Seventeen experienced and currently active Registered Intermediaries with a range of communication specialisms took part in semi-structured interviews, which were analysed thematically. Six main themes emerged from the data: assessment constraints and requirements, essential elements of the assessment process, why the assessment process is effective, ensuring recommendations are followed through, pressures and barriers, and practice development. The Registered Intermediaries stressed the need for further training for themselves as well as for legal professionals, and emphasised the benefits of working as a team throughout the assessment and legal process.
Using social robot PLEO to enhance the well-being of hospitalised children
Authors: Moerman Clara J , Jansens Rianne ML
Published: August 2020

Hospitalisation is stressful for children. Play material is often offered for distraction and comfort. We explored how contact with social robot PLEO could positively affect a child’s well-being. To this end, we performed a multiple case study on the paediatric ward of two hospitals. Child life specialists offered PLEO as a therapeutic activity to children in a personalised way for a well-being related purpose in three to five play like activity sessions during hospital visits/stay. Robot–child interaction was observed; care professionals, children and parents were interviewed. Applying direct content analysis revealed six categories of interest: interaction with PLEO, role of the adults, preferences for PLEO, PLEO as buddy, attainment of predetermined goal(s) and deployment of PLEO. Four girls and five boys, aged 4–13, had PLEO offered as a relief from stress or boredom or for physical stimulation. All but one started interacting with PLEO and showed behaviours like hugging, caring or technical exploration, promoting relaxation, activation and/or making contact. Interaction with PLEO contributed to achieving the well-being related purpose for six of them. PLEO was perceived as attractive to elicit play. Although data are limited, promising results emerge that the well-being of hospitalised children might be fostered by a personalised PLEO offer.
Affordance-based interior design with occupants' behavioural data
Authors: Kim Min-Kyoung
Published: August 2020

For affordance-based design, which is especially lacking in the architecture field, this study investigates the relationships between affordances and interior elements in the built environment by understanding intrinsic affordances by users. The ethnographic case study was conducted by unobtrusively observing participant behaviours during given tasks using video recordings, voice recordings and photographs. The 32 affordances were identified in a public space containing 22 observed affordances and 10 issue affordances. The paper defines the hierarchical nature of the interior elements, including area-level, set-level, object-level and detailed attribute-level elements. An awareness of human-based affordances, where humans can create specific affordances using their bodies and belongings, was significant in the current research. The affordance-interior design element map can be used to support the identification of interior elements that are relevant to certain affordances and to distinguish which affordances are demanded by occupants in the built environment. Overall, designers could embed the affordance concept in the early stages of the design process by choosing more critical affordances and interior elements. The affordance-interior design element matrix and the map may be developed as an initial data repository for affordance-based interior design.
Estimating and optimizing the flexural strength of bonding welded polypropylene sheets by friction-stir welding method
Authors: Mirabzadeh Reza , Parvaneh Vali , Ehsani Amir
Published: August 2020

In recent years, the growing trend of using polymer materials in various industries has led to significant improvements in the methods of production and bonding of polymer materials. The present study aimed to optimize the flexural strength of polypropylene sheets welded by the friction-stir method, which is considered as one of the most efficient methods in this field. The surface quality and mechanical properties of the components produced in this method highly rely on the parameters of rotational speed, linear speed, geometry, and tool tilt. Therefore, this research seeks to evaluate the effect of these parameters on three different levels, both experimentally and statistically, in order to investigate the welding flexural strength. By applying the analysis of variance and Box–Behnken response surface methodology, the results revealed the existence of a significant relationship between the properties and parameters of the process and the possibility to examine the effect of the interaction of different parameters in the process using mathematical modeling and Chart analysis. In addition, optimal models were introduced through process optimization so that the flexural strength of the weld joint was increased by up to 96% of that of the base specimen, after conducting further experimental tests, resulting in confirming the optimal model. Finally, the efficiency of the designed model was evaluated by comparing the measurement errors obtained from the experimental results and the prediction of the model.
A matrix-variate dirichlet process to model earthquake hypocentre temporal patterns
Authors: A. Ray Meredith , Bowman Dale , Csontos Ryan , Van Arsdale Roy B. , Zhang Hongmei
Published: August 2020

Earthquakes are one of the deadliest natural disasters. Our study focuses on detecting temporal patterns of earthquakes occurring along intraplate faults in the New Madrid seismic zone (NMSZ) within the middle of the United States from 1996–2016. Based on the magnitude and location of each earthquake, we developed a Bayesian clustering method to group hypocentres such that each group shared the same temporal pattern of occurrence. We constructed a matrix-variate Dirichlet process prior to describe temporal trends in the space and to detect regions showing similar temporal patterns. Simulations were conducted to assess accuracy and performance of the proposed method and to compare to other commonly used clustering methods such as Kmean, Kmedian and partition-around-medoids. We applied the method to NMSZ data to identify clusters of temporal patterns, which represent areas of stress that are potentially migrating over time. This information can then be used to assist in the prediction of future earthquakes.
Prognostic Significance of Preoperative Neutrophil-Lymphocyte Ratio in Vascular Surgery: Systematic Review and Meta-Analysis
Authors: Jackson Sarah M. , Perry Luke A. , Borg Carla , Ramson Dhruvesh M. , Campbell Ryan , Liu Zhengyang , Nguyen Jacqueline , Douglas Ned , Kok Juliana , Penny-Dimri Jahan
Published: August 2020

Objective:

The global burden of surgical vascular disease is increasing and with it, the need for cost-effective, accessible prognostic biomarkers to aid optimization of peri-operative outcomes. The neutrophil-lymphocyte ratio (NLR) is emerging as a potential candidate biomarker for perioperative risk stratification. We therefore performed this systematic review and meta-analysis on the prognostic value of elevated preoperative NLR in vascular surgery.

Methods:

We searched Embase (Ovid), Medline (Ovid), and the Cochrane Library database from inception to June 2019. Screening was performed, and included all peer-reviewed original research studies reporting preoperative NLR in adult emergent and elective vascular surgical patients. Studies were assessed for bias and quality of evidence using a standardized tool. Meta-analysis was performed by general linear (mixed-effects) modelling where possible, and otherwise a narrative review was conducted. Between-study heterogeneity was estimated using the Chi-squared statistic and explored qualitatively.

Results:

Fourteen studies involving 5,652 patients were included. The overall methodological quality was good. Elevated preoperative NLR was associated with increased risk of long-term mortality (HR 1.40 [95%CI: 1.13-1.74], Chi-squared 60.3%, 7 studies, 3,637 people) and short-term mortality (OR: 3.08; 95%CI: 1.91-4.95), Chi-squared 66.59%, 4 studies, 945 people). Outcome measures used by fewer studies such as graft patency and amputation free survival were assessed via narrative review.

Conclusions:

NLR is a promising, readily obtainable, prognostic biomarker for mortality outcomes following vascular surgery. Heterogeneity in patient factors, severity of vascular disease, and type of vascular surgery performed renders direct comparison of outcomes from the current literature challenging. This systematic review supports further investigation for NLR measurement in pre-vascular surgical risk stratification. In particular, the establishment of a universally accepted NLR cut-off value is of importance in real-world implementation of this biomarker.
Comparison of paclitaxel-coated balloon angioplasty with femoropopliteal bypass surgery in treating femoropopliteal lesions
Authors: Kavala Ali Aycan , Kuserli Yusuf , Turkyilmaz Saygin
Published: August 2020

Objective

To compare drug (paclitaxel)-coated balloon angioplasty with femoropopliteal bypass surgery in the treatment of femoropopliteal lesions.

Methods

A retrospective study was performed between January 2015 and January 2019, covering a four-year period. All subjects who underwent femoropopliteal bypass surgery and drug-coated balloon angioplasty over a four-year period were evaluated. The subjects’ demographic characteristics, lesion characteristics, treatment outcomes and disease-free survival were collected. Subjects were divided into the femoropopliteal bypass group (Group A) and the drug-coated balloon angioplasty (Group B) group.

Results

In total, 220 subjects were enrolled. Both Group A and Group B consisted of 110 subjects. The proportion of patients with a claudication distance between 0 and 50 m was significantly higher in Group A, and the proportion of patients with a claudication distance between 50 and 100 m was significantly higher in Group B ( p = 0.001). In terms of the Rutherford levels, moderate claudication was significantly higher in Group B, and severe claudication was significantly higher in Group A ( p = 0.001). The lesion length for the subjects in Group A was significantly longer than that in Group B (24.61 ± 2.79 mm for Group A and 18.59 ± 3.95 mm for Group B, p = 0.001). The stenosis degree in Group A was also significantly higher than that in Group B (96.82 ± 4.32% for Group A and 94.85 ± 4.55% for Group B, p = 0.001). The duration of the procedure, duration of hospitalization and rate of bleeding in Group A were significantly higher than those in Group B. The incidence of overall morbidity and reintervention rates in Group B were significantly higher than that in Group A. The preoperative ankle brachial index values of the subjects in Group B were statistically significantly higher than those in Group A (0.56 ± 0.08 for Group A and 0.61 ± 0.08 for Group B, p = 0.001). The change in the ankle brachial index measurement of the subjects in Group A with respect to the preprocedure value was significantly greater than that in Group B ( p = 0.001). For primary patency, there was a significant difference between the groups in the distribution of the duplex ultrasound results at the 3rd, 6th, 9th and 12th month control points ( p = 0.001). At all control points, Group A had better primary patency rates, whereas the secondary patency rates did not differ. In total, among the 220 patients, 125 (56.8%) were disease free, and 95 (43.2%) experienced recurrence. The mean disease-free survival times for Group A and Group B were 10.45 ± 0.28 months and 9.11 ± 0.37 months, respectively. The disease-free survival rates were significantly higher in Group A ( p = 0.001, p < 0.05).

Conclusion

Femoropopliteal bypass resulted in better disease-free survival rates than drug-coated balloon angioplasty and serves as an effective modality for the treatment of femoropopliteal lesions.