bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of human umbilical cord blood-derived mesenchymal stem cell isolation and culture methods in serum- and xeno-free conditions
Authors: Nguyen Liem Thanh , Tran Nghia Trung , Than Uyen Thi Trang , Nguyen Minh Quang , Tran Anh Minh , Do Phuong Thi Xuan , Chu Thao Thi , Nguyen Tu Dac , Bui Anh Viet , Ngo Tien Anh , Hoang Van Thanh , Hoang Nhung Thi My
Published: January 2022

Background

Although umbilical cord blood (UCB) is identified as a source of mesenchymal stem cells (MSCs) with various advantages, the success in cell isolation is volatile. Therefore, it is necessary to optimize methods of cord blood-derived MSC (UCB-MSC) isolation and culture. In this study, we evaluated the efficiency of UCB-MSC isolation and expansion using different commercially available serum- and xeno-free media and investigated the capacity of autologous serum and plasma as a supplement to support cell proliferation. Additionally, we defined the presence of multilineage-differentiating stress-enduring (Muse) cells in the UCB-MSC population. Functions of UCB-MSC in in vitro angiogenesis processes and anti-cancer were also verified.

Methods

Mononuclear cells were isolated using density gradient separation and cultured in four commercial media kits, as well as four surface coating solutions. UCB-MSCs were characterized and tested on tube formation assay, and co-cultured with SK-MEL cells in a transwell system.

Results

The results showed that only StemMACS™ MSC Expansion Media is more appropriate to isolate and culture UCB-MSCs. The cells exhibited a high cell proliferation rate, CFU forming capability, MSC surface marker expression, trilineage differentiate potential, and chromosome stability. In addition, the culture conditions with autologous serum coating and autologous plasma supplement enhanced cell growth and colony forming. This cell population contained Muse cells at rate of 0.3%. Moreover, UCB-MSCs could induce the tube formation of human umbilical vein endothelial cells and inhibit more than 50% of SK-MEL cell growth.

Conclusions

UCB-MSCs could be high-yield isolated and expanded under serum- and xeno-free conditions by using the StemMACS™ MSC Expansion Media kit. Autologous serum coating and plasma supplement enhanced cell proliferation. These UCB-MSCs had effected the tube formation process and an anti-cancer impact.
Whole-body biodistribution and radiation dosimetry of [18F]PR04.MZ: a new PET radiotracer for clinical management of patients with movement disorders
Authors: Lehnert Wencke , Riss Patrick J. , Hurtado de Mendoza Ana , Lopez Sandra , Fernandez Gonzalo , Ilheu Marcelo , Amaral Horacio , Kramer Vasko
Published: January 2022

Purpose

[18F]PR04.MZ is a new PET imaging agent for dopamine transporters, providing excellent image quality and allowing for the evaluation of patients with movement disorders such as Parkinson’s disease. The objective of this study was to evaluate the biodistribution and radiation dosimetry of [18F]PR04.MZ by serial PET imaging.

Methods

Six healthy subjects (n = 3 males, n = 3 females) were enrolled in this study. A series of 14 whole-body PET/CT scans were acquired until 5.5 h post-injection of 200 ± 11 MBq of [18F]PR04.MZ. After rigid co-registration, volumes of interest were outlined either on CT or PET images. Time-integrated activity coefficients were calculated for selected source organs. Organ absorbed doses, and the effective dose were calculated using IDAC-Dose 2.1.

Results

Physiological uptake of [18F]PR04.MZ was mainly observed in the striatum, brain, liver, gall bladder, intestine, red marrow and cortical bone. [18F]PR04.MZ was primarily excreted via hepatobiliary clearance and, to a lower extent, via renal clearance. The normalized absorbed doses were highest in gall bladder wall (32.2 ± 6.4 µGy/MBq), urinary bladder wall (27.2 ± 4.5 µGy/MBq), red marrow (26.5 ± 1.4 µGy/MBq), cortical bone surface (26.3 ± 2.5 µGy/MBq), liver (22.5 ± 1.8 µGy/MBq) and kidneys (21.8 ± 1.1 µGy/MBq). The effective dose according to ICRP 60 and 103 was 16.3 ± 1.1 and 16.6 ± 1.5 µSv/MBq, respectively.

Conclusion

[18F]PR04.MZ has a favourable dosimetry profile, comparable to those of other 18F-labelled PET tracers, and is suitable for larger clinical applications.

Trial registration CEC SSM Oriente, Santiago, Chile, permit 20140520.
CXCR4 peptide-based fluorescence endoscopy in a mouse model of Barrett’s esophagus
Authors: Marcazzan Sabrina , Braz Carvalho Marcos J. , Konrad Matthias , Strangmann Julia , Tenditnaya Anna , Baumeister Theresa , Schmid Roland M. , Wester Hans-Jürgen , Ntziachristos Vasilis , Gorpas Dimitris , Wang Timothy C. , Schottelius Margret , Quante Michael
Published: January 2022

Background

Near-infrared (NIR) fluorescence imaging has been emerging as a promising strategy to overcome the high number of early esophageal adenocarcinomas missed by white light endoscopy and random biopsy collection. We performed a preclinical assessment of fluorescence imaging and endoscopy using a novel CXCR4-targeted fluorescent peptide ligand in the L2-IL1B mouse model of Barrett’s esophagus.

Methods

Six L2-IL1B mice with advanced stage of disease (12–16 months old) were injected with the CXCR4-targeted, Sulfo-Cy5-labeled peptide (MK007), and ex vivo wide-field imaging of the whole stomach was performed 4 h after injection. Before ex vivo imaging, fluorescence endoscopy was performed in three L2-IL1B mice (12–14 months old)  by a novel imaging system with two L2-IL1B mice used as negative controls.

Results

Ex vivo imaging and endoscopy in L2-IL1B mice showed that the CXCR4-targeted MK007 accumulated mostly in the dysplastic lesions with a mean target-to-background ratio > 2. The detection of the Sulfo-Cy5 signal in dysplastic lesions and its co-localization with CXCR4 stained cells  by confocal microscopy further confirmed the imaging results.

Conclusions

This preliminary preclinical study shows that CXCR4-targeted fluorescence endoscopy using MK007 can detect dysplastic lesions in a mouse model of Barrett’s esophagus. Further investigations are needed to assess its use in the clinical setting.
Examining proximity to death and health care expenditure by disease: a Bayesian-based descriptive statistical analysis from the National Health Insurance database in Japan
Authors: Hiramatsu Yuji , Ide Hiroo , Tsuchiya Atsuko , Furui Yuji
Published: January 2022

Background

Japan is one of the Organization for Economic Co-operation and Development (OECD) countries where population aging and increasing health care expenditures (HCE) are urgent issues. Recent studies have identified factors other than age, such as proximity to death and morbidity, as contributing factors to the increase in medical costs. It is important to assess HCE by disease and analyze their factors to estimate and improve future HCE.

Methods

We extracted individual records spanning approximately 2 years prior to the death of persons aged 65 to 95 years from the National Health Insurance data in Japan, and used a Bayesian approach to decompose monthly HCE into five disease groups (circulatory, chronic kidney disease, neoplasms, respiratory, and others). The relationship between the proximity to death and the average HCE in each disease group was stratified by sex and age and analyzed using a descriptive statistical method similar to the two-part model.

Results

The average HCE increased rapidly as death approached in most disease groups, but the increase-pattern differed greatly among disease groups, sex, and age groups. The effect of proximity to death on average HCE was small for chronic diseases, but large for lethal diseases. When stratified by age and sex, younger and male decedents tended to have higher average HCE, but the extent of this varied by disease group. The two-year cumulative average HCE for neoplasms in the 65–75 years age group was about six times larger than those in the 85–95 years age group.

Conclusions

In Japan, it was suggested that disease, proximity to death, age, and sex may contribute to HCE. However, these factors interact in a complex manner, and it is important to analyze HCE by disease. In addition, preventing or delaying the severity of diseases with high medical burdens in younger people may be effective in reducing future terminal care costs. These findings have important implications for future projections and improvements of HCE.
Review of As Nomadism Ends: The Israeli Bedouin of the Negev by Avinoam Meir
Authors: Dinero Steven C.
Published: January 2022

Book details

Meir, Avinoam

As Nomadism Ends: The Israeli Bedouin of the Negev

London & New York: Routledge, 2020

268 pages, ISBN: 978-0-3671-6054-8 $49.95 (paper).
The use of social network analysis in social support and care: a systematic scoping review protocol
Authors: Fernández-Peña Rosario , Ovalle-Perandones María-Antonia , Marqués-Sánchez Pilar , Ortego-Maté Carmen , Serrano-Fuentes Nestor
Published: January 2022

Background

In recent decades, the literature on Social Network Analysis and health has experienced a significant increase. Disease transmission, health behavior, organizational networks, social capital, and social support are among the different health areas where Social Network Analysis has been applied. The current epidemiological trend is characterized by a progressive increase in the population’s ageing and the incidence of long-term conditions. Thus, it seems relevant to highlight the importance of social support and care systems to guarantee the coverage of health and social needs within the context of acute illness, chronic disease, and disability for patients and their carers. Thus, the main aim is to identify, categorize, summarize, synthesize, and map existing knowledge, literature, and evidence about the use of Social Network Analysis to study social support and care in the context of illness and disability.

Methods

This scoping review will be conducted following Arksey and O'Malley's framework with adaptations from Levac et al. and Joanna Briggs Institute’s methodological guidance for conducting scoping reviews. We will search the following databases (from January 2000 onwards): PubMed, MEDLINE, Web of Science Core Collection, SCOPUS, CINAHL, PsycINFO, Cochrane Database of Systematic Reviews, PROSPERO, and DARE. Complementary searches will be conducted in selected relevant journals. Only articles related to social support or care in patients or caregivers in the context of acute illnesses, disabilities or long-term conditions will be considered eligible for inclusion. Two reviewers will screen all the citations, full-text articles, and abstract the data independently. A narrative synthesis will be provided with information presented in the main text and tables.

Discussion

The knowledge about the scientific evidence available in the literature, the methodological characteristics of the studies identified based on Social Network Analysis, and its main contributions will highlight the importance of health-related research's social and relational dimensions. These results will shed light on the importance of the structure and composition of social networks to provide social support and care and their impact on other health outcomes. It is anticipated that results may guide future research on network-based interventions that might be considered drivers to provide further knowledge in social support and care from a relational approach at the individual and community levels.

Trial registration

Open Science Frameworkhttps://osf.io/dqkb5.
A program evaluation of the Innovative Teen Pregnancy Prevention Programs (iTP3) Project
Authors: Garcia Kristen M. , Esquivel Christi H. , Garney Whitney R. , Wilson Kelly L. , Farmer Jennifer
Published: January 2022

Background

Teen pregnancy prevention in the United States has traditionally focused on the development, testing, and subsequent implementation of a set of evidence-based programs (EBPs), recommended nationally. However, these existing EBPs often do not prioritize the most at-risk or vulnerable populations.

Methods

The Innovative Teen Pregnancy Prevention Programs (iTP3) project was funded to facilitate the development of new, innovative programs to reach disparate populations. Through a mixed methods design, iTP3 evaluated the process and resulting innovative programs from five iterative cohorts of funded organizations, referred to as Innovators. iTP3 utilized both a traditional funding model with more traditional methods of capacity building assistance, but transitioned over time to a design-focused funding model in which organizations and individuals developed innovative programs through an intensive human centered design process.

Results

Evaluation results showed that the resulting portfolio of programs had differences in the types of programs resulting from the differing funding models. Notable differences among programs from the two funding models include program length, along with personnel, time, and resources needed to develop and manage.

Conclusion

Both traditional and design funding models led to innovative programs, with notable differences in the development process and resulting programs.
Efficacy of mupirocin, neomycin and octenidine for nasal Staphylococcus aureus decolonisation: a retrospective cohort study
Authors: Allport J. , Choudhury R. , Bruce-Wootton P. , Reed M. , Tate D. , Malviya A.
Published: January 2022

Background

Periprosthetic joint infection (PJI) causes significant morbidity. Methicillin sensitive Staphylococcus aureus (MSSA) is the most frequent organism, and the majority are endogenous. Decolonisation reduces PJIs but there is a paucity of evidence comparing treatments. Aims; compare 3 nasal decolonisation treatments at (1) achieving MSSA decolonisation, (2) preventing PJI.

Methods

Our hospital prospectively collected data on our MSSA decolonisation programme since 2013, including; all MSSA carriers, treatment received, MSSA status at time of surgery and all PJIs. Prior to 2017 MSSA carriers received nasal mupirocin or neomycin, from August 2017 until August 2019 nasal octenidine was used.

Results

During the study period 15,958 primary hip and knee replacements were performed. 3200 (20.1%) were MSSA positive at preoperative screening and received decolonisation treatment, 698 mupirocin, 1210 neomycin and 1221 octenidine. Mupirocin (89.1%) and neomycin (90.9%) were more effective at decolonisation than octenidine (50.0%, P < 0.0001). There was no difference in PJI rates (P = 0.452).

Conclusions

Mupirocin and neomycin are more effective than octenidine at MSSA decolonisation. There was poor correlation between the MSSA status after treatment (on day of surgery) and PJI rates. Further research is needed to compare alternative MSSA decolonisation treatments.
Spatiotemporal functional modeling of postseismic deformations after the 2011 Tohoku-Oki earthquake
Authors: Fujiwara Satoshi , Tobita Mikio , Ozawa Shinzaburo
Published: January 2022

Postseismic deformations continue to occur for a long period after major earthquakes. Temporal changes in postseismic deformations can be approximated using simple functions. Since the 2011 Tohoku-Oki earthquake, operating global navigation satellite system stations have been continuously accumulating a remarkable amount of relevant data. To verify the functional model, we performed statistical data processing on postseismic deformations due to this earthquake and obtained their spatiotemporal distribution. Moreover, we approximated the postseismic deformations over a relatively wide area with a standard deviation of residuals of 1 cm for approximately 10 years using a combined functional model of two logarithmic and one exponential functions; however, the residuals from the functional model exhibited a marked deviation since 2015. Although the pattern of postseismic deformations remained unaltered after the earthquake, a change in the linear deformation occurred from 2015 to date. We reduced the overall standard deviation of the residuals of > 200 stations distributed over > 1000 km to < 0.4 cm in the horizontal component by enhancing the functional model to incorporate this linear deformation. Notably, time constants of the functions were similarly applicable for all stations and components. Furthermore, the spatial distribution of the coefficients of each time constant were nonrandom, and the distribution was spatially smooth, with minute changes in the short wavelengths in space. Thus, it is possible to obtain a gridded model in terms of a spatial function. The spatial distributions of short- and long-period components of the functional model and afterslip and viscoelastic relaxation calculated using the physical model were similar to each other, respectively. Each time function revealed a connotation regarding the physical processes, which provided an understanding of the physical phenomena involved in seismogenesis. The functional model can be used to practical applications, such as discerning small variations and modeling for precise positioning.

Graphical Abstract
Role of circulating molecules in age-related cardiovascular and metabolic disorders
Authors: Hsiao Yung Ting , Shimizu Ippei , Yoshida Yohko , Minamino Tohru
Published: January 2022

Studies analyzing heterochronic parabiosis mice models showed that molecules in the blood of young mice rejuvenate aged mice. Therefore, blood-based therapies have become one of the therapeutic approaches to be considered for age-related diseases. Blood includes numerous biologically active molecules such as proteins, metabolites, hormones, miRNAs, etc. and accumulating evidence indicates some of these change their concentration with chronological aging or age-related disorders. The level of some circulating molecules showed a negative or positive correlation with all-cause mortality, cardiovascular events, or metabolic disorders. Through analyses of clinical/translation/basic research, some molecules were focused on as therapeutic targets. One approach is the supplementation of circulating anti-aging molecules. Favorable results in preclinical studies let some molecules to be tested in humans. These showed beneficial or neutral results, and some were inconsistent. Studies with rodents and humans indicate circulating molecules can be recognized as biomarkers or therapeutic targets mediating their pro-aging or anti-aging effects. Characterization of these molecules with aging, testing their biological effects, and finding mimetics of young systemic milieu continue to be an interesting and important research topic to be explored.
Incidence and perioperative risk factors for surgical site infections in neurosurgery: prospective observational study
Authors: Abdel-Latif Assem Mouneir , Moharram Amira A. , Higazy Ahmed , Ghoneim Nehal I. , Shafei Omnia , Abdelhady Salma G. , Assal Ghadeer , Ibrahim Aly
Published: January 2022

Background

Surgical site infections (SSI) represent a burden on the health care system especially in developing countries with significant morbidity and mortality. In Egypt, especially in our institution, there is no registry for the SSI rate or the contributing factors with no clear guidelines regarding the regimen of perioperative antibiotic prophylaxis. Our study was conducted to assess the local practice and to calculate the rate and risk factors of SSI.

Patients and methods

A prospective registry was established at the Neurosurgery Department, Demerdash teaching hospital Ain Shams University, Cairo, Egypt. All patients who underwent elective neurosurgical procedures were included in this study. Trauma patients were excluded. Patients were followed-up for incident SSI for 1 month postoperatively. SSIs were identified based on CDC criteria and a standardized data collection form predictor variables including patient characteristics, preoperative, intraoperative, and postoperative factors along with the pattern of antimicrobial prophylaxis.

Results

The study included 248 patients with 1-month postoperative follow-up. An SSI rate of 19% was recorded being mainly in patients below 10 years of age. Postoperative CSF leak was noticed to be the most significant risk factor of SSI in our study (p value < 0.01). Sixty five percent of culture results showed infection with gram-negative bacilli with the predominance of Acinetobacter.

Conclusion

Prolonged use of perioperative antibiotics does not seem to have an added benefit in SSI prevention. Tailoring of the used antibiotic regimen is highly recommended according to the latest antimicrobial prophylaxis guidelines and the local culture and sensitivity results.
Iatrogenic operative hysteroscopic intravascular absorption syndrome: a recurring possibility!
Authors: Kadni Reena Ravindra , Sarkar Mita Eunice , Menon Indira , Kongari Anne Marie
Published: January 2022

Background

Operative hysteroscopic intravascular absorption syndrome (OHIA) is the constellation of signs and symptoms due to fluid overload during hysteroscopic procedures. It can present with hyponatremia, deranged coagulation, pulmonary, and cerebral edema which are life-threatening issues. To our knowledge, this is the first reported case of recurrent OHIA syndrome which was managed uneventfully.

Case presentation

A 26-year-old American Society of Anesthesiologist (ASA) patient presented with primary infertility and prolonged, heavy menstruation. The abdominal and transvaginal ultrasound (USG) revealed a large posterior intramural fibroid of size 6.1 cm × 4.2 cm with submucosal intracavitary extension. She was planned for two-step laparoscopic and hysteroscopic evaluation and resection of the myoma under general anesthesia. Severe OHIA syndrome occurred with 1.5% glycine in phase 1 resection and recurred with 0.9% sodium chloride in phase 2 resection of intrauterine myoma at two different surgical settings. The uniqueness of this case is recurrence of OHIA syndrome in the same patient despite the use of normal saline (NS) due to lack of precautionary measures for fluid management.

Conclusions

Normal saline as an irrigating medium may not eliminate the risk of OHIA. Lack of adequate fluid management strategies can be detrimental especially in cases of hysteroscopic myoma resections. Following a standard protocol for vigilant monitoring under general anesthesia is the key in successful management.
Magnesium sulphate within multimodal analgesia, pre-emptive, or preventive analgesia
Authors: Kamel Walid Y. , Shoukry Aktham Adel
Published: January 2022

Background

Magnesium (Mg) is a non-competitive N-methyl d-aspartate receptor antagonist with antinociceptive effects. Multimodal therapy is the optimal strategy for perioperative pain control to minimize the need for opioids. Inflammation caused by tissue trauma or direct nerve injury is responsible for the perioperative pain. The concept of “pre-emptive” analgesia, analgesic strategies administered prior to the stimulus, can modify the peripheral and central nervous system processing of noxious stimuli, thereby reducing central sensitization, hyperalgesia, and allodynia remains controversial. A more encompassing approach to the reduction of postoperative pain is the concept of “preventive” analgesia. The purpose of the study is to detect the proper use of MgSO4 as an analgesic being a non-competitive N-methyl d-aspartate (NMDA).

Results

There is no statistically significant difference in the haemodynamic parameters, intraoperative (33% vs 20%) and postoperative requirement for analgesics 6.6% vs 10% among groups I and II, respectively. There is no significant difference in the numerical analogue scale, where 16 vs 17 patients with no pain, 12 vs 10 with mild pain, and 2 vs 3 with moderate pain in groups I and II, respectively.

Conclusion

The use of MgSO4 in a bolus with or without infusion is comparable in the control of intraoperative and postoperative pain.
Oral cavity infection by the SARS-CoV-2: emphasizing the essence of masking and peptide therapeutics
Authors: Ibiang Glory Omini , Malachi Joseph , Ibiang Mercy Omini , Chukwudi Daniel Kenechi , Durojaye Olanrewaju Ayodeji
Published: January 2022

The SARS-CoV-2 has infected many people globally with the ravaging COVID-19; a disease, which has become challenging for every aspect of modern healthcare. The saliva and oral mucosa are sites of high risk for increased viral loads, and aside from the usual epithelial functions like lining and protection, the oral mucosa is also specialized for crucial functions, such as secretion, mastication, sensory perception, and taste perception. The human ACE2 receptor has been extensively studied for its essential role in the regulation of blood pressure homeostasis. However, scRNA-Seq studies have revealed high expression levels of the protein in keratinized epithelial surfaces of the oral cavity. The SARS-CoV-2 have access to the host’s body by binding to the ACE2 receptor, leading to the cleavage and major conformational changes in the viral spike glycoprotein for the release of its nucleocapsid into the cellular cytoplasm. This proteolytic cleavage is carried out by the TMPRSS2 and cathepsin L. In this study, we harnessed the information from the binding interface of TMPRSS2 and PAI-1 (a protease inhibitor known to inhibit the TMPRSS2 and several other proteases) to design a potential therapeutic peptide for the inhibition of the TMPRSS2, while also emphasizing the need for preventive masking.
Neuroimaging findings in hospitalized patients with COVID-19
Authors: Abdelzaher Ahmed , AlQatam Mohammad , Alsarraf Lamyaa , Beheiri Mohamed H. , Shehata Shehata Farag , Elsebaie Nermeen A.
Published: January 2022

Background

Variable neuroimaging findings have been reported in patients with coronavirus disease 2019 (COVID-19). In addition to respiratory symptoms, many neurologic manifestations of COVID-19 are increasingly reported and variable neuroimaging findings have been observed in patients with COVID-19. Our aim was to describe findings observed in hospitalized patients with COVID-19, presenting with acute neurologic manifestations and undergoing computed tomography (CT) or magnetic resonance imaging (MRI) of the brain.

Methods

We performed a retrospective study involving patients with laboratory-confirmed SARS-COV-2 infection, admitted to our hospital between July 1 and December 30, 2020. Patients who presented with acute neurologic symptoms and required neuroimaging were only included in the study. Neuroimaging examinations were evaluated for the presence of, infarction, hemorrhage and encephalopathy. The frequency of these findings was correlated with clinical variables, including presence of comorbidities, requirement for intensive care unit admission, and duration between admission and onset of neurologic signs and symptoms as documented in the hospital medical records.

Results

A total of 135 patients underwent at least one cross-sectional imaging of the brain, the median age of these patients was 63 years, and 72% were men. Disturbed level of consciousness was the most common neurologic symptom (80.7%). Acute neuroimaging findings were found in 34 patients (25.2%) including; acute ischemic infarcts (16/135; 11.9%), intracranial hemorrhages (9/135, 6.7%), cerebral venous thrombosis (2/135; 1.5%), posterior reversible encephalopathy syndrome (1/135; 0.7%), and hypoxic-ischemic encephalopathy (6/135, 4.4%). There was no statistically significant difference in patient age (p = 0.062), sex (0.257), presence of comorbidities (p = 0.204), intensive care unit admission (p = 0.326) and duration between admission and onset of neurologic signs and symptoms (p = 0.755), in patients with positive versus negative neuroimaging studies.

Conclusions

Our study showed that cerebrovascular complications, ischemic and hemorrhagic were the most frequent imaging finding in hospitalized patients with COVID-19. Knowledge about these potentially serious complications can help optimize management for these patients.
Bilateral adrenal haemorrhage with renal infarction after ChAdOx1 nCoV-19 AstraZeneca vaccination
Authors: Tha Tun , Martini Iana , Stefan Elena , Redla Sridhar
Published: January 2022

Vaccine-induced thrombotic thrombocytopaenia (VITT) is a rare syndrome associated with the ChAdOx1 nCoV-19 (AstraZeneca) vaccine. We detail a case of vaccine-induced thrombotic thrombocytopaenia in a 47-year-old female who was found to have bilateral adrenal haemorrhage, renal vein thrombosis, renal infarction and pulmonary embolism 13 days post-vaccination with ChAdOx1 nCoV-19.
ANALISANDO CRENÇAS E CONCEPÇÕES DE EDUCAÇÃO FINANCEIRA SOB A ÓTICA DOS PILARES DA METODOLOGIA DSOP: UM ESTUDO JUNTO AOS ARTESÃOS DA ASSOCIAÇÃO COSTA LESTE DE ARTESÃO DE MATO GROSSO DO SUL (ACLAMS)
Authors: Rizzo Marçal Rogério , Ribeiro Silvio Paula , Domingos Reinaldo Aparecido , Aquino Aline Alves Andrade de
Published: January 2022

A educação financeira tem sido, na atualidade, tema de reflexão e discussão, potencializado, no Brasil, em razão das crises econômicas e do apelo ao consumo vivenciado nas últimas décadas. O presente estudo articula uma análise da aplicação de pontos e concepções de educação financeira sob a ótica dos pilares da metodologia DSOP (Diagnosticar, Sonhar, Orçar e Poupar) junto aos artesãos da Associação Costa Leste de Artesão de Mato Grosso do Sul (ACLAMS), localizada no município de Três Lagoas/MS. Parte-se da premissa de que a maioria dos artesãos ligados à ACLAMS necessitariam de mais conhecimentos ligados à educação financeira, especialmente em aspectos que tenham aderência com a metodologia DSOP. Para validação dessa hipótese, foi aplicado, no mês de novembro de 2020, um questionário com questões abertas e de múltipla escolha junto aos artesãos, constatando-se que eles têm pouco conhecimento de temas relacionados à educação financeira e finanças pessoais, bem como suscitando a necessidade de aprimoramento dos conhecimentos e atitudes dos artesãos no que tange à educação financeira.
A CONDIÇÃO FINANCEIRA DE EFICÁCIA DA LEI E O SEU CONTROLE PELO TRIBUNAL DE CONTAS DA UNIÃO
Authors: Corval Paulo Roberto Dos Santos , Tognoc Leonardo Oliveira
Published: January 2022

RESUMOObjetivo: Buscou-se neste artigo analisar a postura institucional do Tribunal de Contas da União a partir da compreensão de suas competências e do modo como tem ampliado o seu protagonismo político-administrativo por meio não apenas das atividades de controle e fiscalização das políticas públicas aprovadas e implementadas, mas, também, de forma especial, pelo controle financeiro da eficácia da lei e, por conseguinte, do próprio Legislativo. Metodologia: a pesquisa teórica do tipo jurídico-dogmática foi desenvolvida a partir do estudo do acórdão paradigmático de nº 1907/2019, prolatado pelo Tribunal de Contas da União, bem como do exame da normatividade constitucional e infraconstitucional voltada às finanças públicas, dialogando com trabalhos doutrinários que exemplificam o estado da arte aplicável ao tema e ao objeto no âmbito do direito financeiro e constitucional.Resultados: considerou-se, ao final, que ao Poder Legislativo, por meio da legislação orçamentária, autolimitado por suas escolhas institucionais em finanças públicas, cabe, originariamente, o controle da condição financeira da eficácia da lei, sem prejuízo de que o órgão autônomo de contas, tendo em vista a autolimitação legislativa reforçada nos últimos anos pela textualidade constitucional, verifique a eficácia do atos legislativos que mobilizam recursos públicos como mecanismo adequado, inclusive, ao reforço da preservação dialógica da autonomia e harmonia dos Poderes.Contribuições: a principal contribuição deste estudo consiste no apontamento da  insuficiência do instrumental analítico oferecido pela dogmática jurídico-financeira contemporânea – e seu legado histórico – para promover o aprofundamento reflexivo da temática aberta pelo Acórdão n.º 1907/2019, de modo a indicar, na forma de três teses programáticas integradas, direcionamentos que à doutrina cabe acolher com imaginação institucional construtora, pois o campo epistêmico do direito financeiro não contempla, de forma sistematizada, o referido protagonismo político-administrativo da Corte de Contas da União.
Review of: Epaminonda I. Stamatiade, BIOGRAFIILE MARILOR DRAGOMANI (INTERPRETI) GRECI DIN IMPERIUL OTOMAN,[The lives of the Greek great dragomans (interpreters) in the Ottoman Empire] translation from Greek and translator’s foreword by Constantin Erbiceanu, preface by Ioan-Aurel Pop, edition supervised, afterword and notes by Rodica Baconsky and Alina Pelea, Cluj-Napoca: Casa Cărţii de Ştiinţă, 2016, 148 pages.
Authors: Sfoini Alexandra
Published: January 2022

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Palimpsests of memory: the medieval city of Athens in modern and postmodern contexts
Authors: Albani Jenny P.
Published: January 2022

This article addresses attitudes towards the medieval past of Athens from modern to postmodern times. Athens, a symbol of classical civilisation, had become a provincial Byzantine centre. From the proclamation of Athens in 1833 as the capital of the modern Greek state to about 1880, archaeological research in Athens focused on classical antiquities at the expense of the preservation of monuments of the Middle Ages, which was regarded as a period of decline. The historical and artistic value of Athenian medieval monuments has been acknowledged since the late nineteenth century. The international progress of Byzantine studies, the national narrative on the continuity of Greek history, the political concept of the megali idea (“Great Idea”), and contemporary state policies based on “diachrony and synergy” contributed to this significant ideological shift. Athens is, however, still renowned and admired worldwide for its classical past, with its medieval cultural heritage less highlighted.
Recent titles
Authors: Historical Review La Revue Historique
Published: January 2022

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Gender and sexuality in contemporary Greek theatre: red-light landscapes and city legends
Authors: Rosi Lina
Published: January 2022

The article explores the representation of female sexuality, in particular prostitution and its association with urban landscapes. The subject forms part of a wider research venture examining the different ways in which contemporary Greek theatre depicts and discusses the female body, female discourse and women’s experiences. The analysis of recent productions focuses on two major points: first, on the mise en scène of the prostitute body and, second, on the way in which each production exposes the association between the characters’ biography and the geography and history of the city. Our aim does not lie in discussing the productions’ ideological views on the issue of prostitution and the contemporary sex industry, but in exploring the mode in which the stage narrative operates as a field in which the life story of these women is first heard and performed and then incorporated into the collective narrative of the city’s history. The productions discussed are Η τελευταία μάσκα–Fallimento (The Last Mask–Fallimento), based on a text by Kostas Logaras, adapted for the stage and directed by Thodoros Terzopoulos (2006); Η γυναίκα της Πάτρας (The Woman of Patras), based on a text by Giorgos Chronas and adapted for the stage and directed by Lena Kitsopoulou (2010); and Γκάμπυ (Gaby), based on Gabriella Ousakova’s autobiography, adapted for the stage by Anastasia Tzellou and Kirki Karali and directed by Karali (2015).
Selective Memory and the Legacy of Archaeological Figures in Contemporary Athens: The Case of Heinrich Schliemann and Panagiotis Stamatakis
Authors: Antoniadis Vyron , Kouremenos Anna
Published: January 2022

The legacy of antiquity has loomed large over the Greek capital since thefoundation of the modern Greek state. Archaeologists have served as the main catalysts in the country’s endeavour to connect antiquity and modernity. Thus, the legacy of deceased archaeologists is tangible in many parts of Athens and a reminder of the significance of archaeology as a discipline in modern Greece. This article examines how the memory ofHeinrich Schliemann and Panagiotis Stamatakis has been appropriated (or misappropriated) in the Greek capital. They worked together to bring to light treasures from Mycenae (1876) but shared a contemptuous relationship for the remainder of their lives. We aim to understandhow society and the state treated not only the mortal remains of these two individuals but also their legacies. Hence, the abundance or absence of material evidence in Athens related to the maintenance of their memory will reveal how the archaeologists themselves worked to preserve or erase their posthumous legacy and how this has been appropriated.
Changing the Map in Greece and Italy: Place-name Changes in the Nineteenth Century
Authors: Kyramargiou Eleni , Papakondylis Yannis , Scalora Fransesco , Dimitropoulos Dimitris
Published: January 2022

The concern of the newly founded Kingdom of Greece for the reestablishment of old place names dates to 1833 and was due to a clear and deliberate effort to break with the Ottoman past and connect the modern Greek state with ancient and Byzantine Greece. In post-Risorgimento Italy, the fundamental causes of toponymic changes wasto lessen the potential for confusion between the numerous homonymous municipalities that, once part of various sovereign states, were now part of a single nation. This article discusses the parallel paths that Greece and Italy followed on the renaming issue, where the internal discourse evolved within similar political and ideological parameters, both at an administrative and public dialogue level. However, despite their similarities, the final decisions in Greece and Italy were dictated by, firstly, the administrative organisation and structure selected by each country and, secondly, the political and ideological priorities, which were set in direct correlation with the domestic political conflicts, as well as the different circumstances each country faced in relation to its borders and the rise of antagonistic neighbouring nationalisms.
Commercial Structures and the Globalisation of Viticulture in Catalonia: From Brandy to Wine and Cava (Eighteenth–Twentieth Centuries)
Authors: Ferrer-Alos Llorenç
Published: January 2022

This paper analyses the evolution of viticulture in Catalonia since theeighteenth century, when the industry entered the international market, with massive exports of brandy to northern Europe and the Spanish colonial market. In the nineteenth century, Catalan viticultural produce was exported mainly to Latin America in exchange for the importation of cotton. After the phylloxera crisis, viticulture experienced difficulty in internationalisation until the specialisation in cava, a sparkling wine made in the same way as champagne, kept the wine production going. In the twenty-first century, thespecialisation in quality wines is also related to the export to international markets.
Lessons of History: An Impossible Equation? Towards New Perspectives on Historical Learning
Authors: Karlsson Klas-Göran
Published: January 2022

Lessons of history are two-sided cultural products. They serve as activeinstruments of temporal orientation in a society in which historical trajectories seem obsolete and the future open, but they are also passively framed within historical cultures that often have prefigured them. Thus, lessons are seldom arbitrarily constructed. While lessons of history for many centuries were highly esteemed as guides to the future from the viewpoint of a practical past, and still are among economists, politicians and social scientists, few professional historians have trust in lessons. The distrust is explained from the lessons’ lack of congruence with traditional professional standards, but also from a frequent use of historical lessons for ideological and political purposes. The purpose of this essay is partly to discuss the theoretical assumptions behind lessons of history, partly to argue in favour of a more constructive use of lessons that can meet reasonable scholarly requirements.
Mathieu Grenet, La fabrique communautaire: Les Grecs à Venise, Livourne et Marseille, 1770–1840
Authors: Tsiptsios Lukas
Published: January 2022

Review of: Mathieu Grenet, La fabrique communautaire: Les Grecs à Venise, Livourne et Marseille, 1770–1840
Introduction
Authors: Gardikas Katerina
Published: January 2022

This collection of articles was conceived long before the outbreak and worldwide spread of Covid-19. It was intended as a review of recent trends in the writing of modern medical history in Greece thanks to the broader social relevance of public health history. While it still represents current ideas on the history of health and medicine among its Greek practitioners, it appears, nonetheless, at a time when public opinion has put the notions of public health, contagion and governance into sharp relief as societies are being overwhelmed by insecurity and a primal sensation of fear. Thus, public health and social medicine have entered the historiographical limelight.
Comparison of effects of medicinal cannabis or standard palliative care on quality of life of patients with cholangiocarcinoma in Northeast Thailand
Authors: Phansila Narisara , Sittiwet Chaiyasit , Wongkongdech Ranee
Published: January 2022

Background: Cholangiocarcinoma (CCA) has a poor prognosis and is a major cause of mortality and suffering in Thailand’s Northeastern (Isaan) Region.  

Methods: This prospective cohort study aimed to compare the health-related quality of life (HRQoL) among 72 newly diagnosed CCA patients; 42 patients who received cannabis treatment (CT) and 30 patients who received a standard palliative care treatment (ST). The study was carried out between 1st September 2019 to 31st October 2020.  Data were collected from patients from oncology clinics of six hospitals in five provinces of northeast Thailand. The HRQoL was measured at baseline, and at 2 and 4 months after diagnosis by the European Organisation for Research and Treatment of Cancer (EORTC) Core Quality of Life questionnaires QLQ-C30, and QLQ-BIL21. The Mann-Whitney U-test was performed to compare quality of life scores between the two patient groups and Wilcoxon signed rank test was performed to compare within groups QoL scores at pre-treatment, and 2 and 4 month follow-ups.

Results: Global health status and functional scales, for both groups were high at pre-treatment. At 2 and 4 month follow-up, CT group patients had consistent statistically significantly better Palliative Performance Scale (PPS), and QoL scores, and many symptom scores than the ST group.  

Conclusions: Medicinal cannabis may increase QoL for advanced CCA patients. Our findings support the importance of early access to palliative cannabis care clinic before the terminal and acceleration phase close to death.
Point of care SARS-CoV-2 nucleic acid testing in schools improves school attendance
Authors: Collier Dami A. , Bousfield Rachel , Gkrania-Klotsas Effrossyni , Gupta Ravindra K.
Published: January 2022

Background: National lockdowns have led to significant interruption to children’s education globally. In the Autumn term in 2020, school absence in England and Wales was almost five times higher than the same period in 2019. Transmission of SARS-CoV-2 in schools and ongoing interruption to education remains a concern. However, evaluation of rapid point of care (POC) polymerase chain reaction (PCR) testing in British schools has not been undertaken.

Methods: This is a survey of secondary schools in England that implemented PCR-based rapid POC testing. The study aims to measure the prevalence of SARS-CoV-2 infection in schools, to assess the impact of this testing on school attendance and closures, and to describe schools experiences with testing. All schools utilised the SAMBA II SARS-CoV-2 testing platform.

Results: 12 fee-paying secondary schools in England were included. Between September 1st 2020 and December 16th 2020, 697 on site rapid POC PCR tests were performed and 6.7% of these were positive for SARS-CoV-2 infection. There were five outbreaks in three schools during this time which were contained. Seven groups of close contacts within the school known as bubbles had to quarantine but there were no school closures. 84% of those tested were absent from school for less than one day whilst awaiting their test result. This potentially saved between 1047 and 1570 days off school in those testing negative compared to the NHS PCR laboratory test. Schools reported a positive impact of having a rapid testing platform as it allowed them to function as fully as possible during this pandemic.

Conclusions: Rapid POC PCR testing platforms should be widely available and utilised in school settings. Reliable positive tests will prevent outbreaks and uncontrolled spread of infection within school settings. Reliable negative test results will reassure students, parents and staff and prevent disruption to education.
DEPRESSIVE DISORDERS AMONG STUDENTS OF MEDICAL HIGHER EDUCATIONAL INSTITUTIONS
Authors: Moskalenko O. L. , Derevyannykh E. V. , Balashova N. A. , Yaskevich R. A.
Published: January 2022

The article presents a review of the literature on the current problem of medicine-depressive disorders among medical students. The need to study the problem of depressive disorders among students of medical higher educational institutions is due to their high frequency and negative impact on the quality of life of students.
Problems of Formation of System Thinking in Modern Russian Education
Authors: Kuz'minova T. , Ashurbekov R.
Published: January 2022

The construction of new, market-based economic relations in Russia in the early 90s of the last century was accompanied by a radical transformation of the education system to the Bologna standard. At the same time, Western scientists - teachers drew attention to the work on the cognitive development of the child by L.S. Vygotsky, the theory of developmental education by P.Ya. Galperin, the theory of inventive problem solving by G.S. Altshuller and the results of research by other scientists providing the formation of systems thinking in Soviet education.

The article shows that the documents regulating the development of Russian education include the formation of systematic and critical thinking in students, but in practice this is not always implemented. The directions of transformation of the Russian education system since the beginning of building market relations in the 90s of the last century are identified as the cause of the current situation.

The formation of systems thinking in higher education should consider the peculiarities of the age dynamics of adults. The most developed figurative and verbal thinking among students makes it possible to use the teaching methods of V.F. Shatalov, which reduces the time for studying educational materials by more than 30 times in comparison with classical teaching methods.
Research of the Russian Labor Market and Peculiarities of Human Resources in the Period of Economic Restoration in a Pandemic
Authors: Zaharov D. , Kashtanova YEkatyerina
Published: January 2022

This article examines the current state, operating conditions and forecasts for the development of the Russian labor market after the coronavirus pandemic in 2020. The growth of the gross domestic product was revealed in July 2021, compared to July 2020. It was noted that the most important factor in the recovery and further development of economic activity in the first half of 2021 was the consumer demand of the population. General trends in the labor market are showing positive dynamics, and the process of increasing real wages has continued. The recovery processes brought workers' cash incomes closer to the indicators of 2019. It was noted that the development of the labor market in the near future will be based on the implementation in the Russian Federation of a state program called "Promotion of employment of the population", in addition, national projects have been developed: "Demography", "Small and medium-sized businesses and support for individual entrepreneurial initiative".