bluuebunny/crossref_metadata_2025 huggingface dataset:
Data mining of PubChem bioassay records reveals diverse OXPHOS inhibitory chemotypes as potential therapeutic agents against ovarian cancer
Authors: Sharma Sejal , Feng Liping , Boonpattrawong Nicha , Kapur Arvinder , Barroilhet Lisa , Patankar Manish , Ericksen Spencer
Published: May 2024

Focused screening on target-prioritized compound sets can be an efficient alternative to high throughput screening (HTS). For most biomolecular targets, compound prioritization models depend on prior screening data or a target structure. For phenotypic or multi-protein pathway targets, it may not be clear which public assay records provide relevant data. The question also arises as to whether data collected from disparate assays might be usefully consolidated. Here, we report on the development and application of a data mining pipeline to examine these issues. To illustrate, we focus on identifying inhibitors of oxidative phosphorylation, a druggable metabolic process in epithelial ovarian tumors. The pipeline compiled 8415 available OXPHOS-related bioassays in the PubChem data repository involving 312,093 unique compound records. Application of PubChem assay activity annotations, PAINS, and Lipinski-like bioavailability filters yields 1,852 putative OXPHOS-active compounds that fall into 464 clusters. These chemotypes are diverse but have relatively high hydrophobicity and molecular weight but lower complexity and drug-likeness. These chemotypes show a high abundance of bicyclic ring systems and oxygen containing functional groups including ketones, allylic oxides (alpha/beta unsaturated carbonyls), hydroxyl groups, and ethers. In contrast, amide and primary amine functional groups have a notably lower than random prevalence. UMAP representation of the chemical space shows strong divergence in the regions occupied by OXPHOS-inactive and -active compounds. Of six compounds selected for experimental validation, 4 showed statistically significant inhibition of electron transport in bioenergetics assays. Two of these four compounds, lacidipine and esbiothrin, increased in intracellular oxygen radicals (a major hallmark of most OXPHOS inhibitors) and decreased the viability of two ovarian cancer cell lines, ID8 and OVCAR5. Finally, data from the pipeline were used to train random forest and support vector classifiers that effectively prioritized OXPHOS inhibitory compounds within a held-out test set (ROCAUC 0.962 and 0.927, respectively) and on another set containing 44 documented OXPHOS inhibitors outside of the training set (ROCAUC 0.900 and 0.823). This prototype pipeline is extensible and could be adapted for focus screening on other phenotypic targets for which sufficient public data are available.
Direct Integration of Ferroelectric Hafnium Zirconium Oxide as Top-Gate High−κ Dielectrics for Two-Dimensional Transistors
Authors: Lin Yen-Fu , Lin Che-Yi , Chen Bo-Cia , Liu Yu-Chen , Kuo Shang-Fu , Tsai Hsien-Chi , Chang Yuan-Ming , Kuo Chang-Yang , Chang Chun-Fu , Chen Jyun-Hong , Chu Ying-Hao , Yamamoto Mahito , Shen Chang-Hong , Chueh Yu-Lun , Chiu Po-Wen , Chen Yi-Chun , Yang Jan-Chi
Published: May 2024

Transistor miniaturization enables integrating billions on a chip but also introduces heat and mobility issues. Two-dimensional (2D) semiconductors, with their ultrathin nature, offer a promising solution to achieving superior gate control. However, the lack of insulators suitable for integration into fully scalable 2D process flows limits their practical use. Here, we report the integration of freestanding Hf0.5Zr0.5O2 (HZO) membranes as top-gate high-κ dielectrics in conjunction with 2D semiconductors. The HZO dielectrics exhibit classic ferroelectric feature, boasting high dielectric constant (~ 19.5), along with low leakage current (< 2.6×10− 6 A cm− 2 at 1 MV cm− 1). Capitalizing on these advantages, we fabricate molybdenum disulfide (MoS2) transistors with HZO dielectrics, achieving an on/off ratio of 109 and a subthreshold swing of 53 mV dec− 1. Additionally, we demonstrate HZO-gated 2D transistors’s capability to implement inverter, NAND, NOR, AND, OR, XOR, XNOR logic functions and a 1-bit full adder. Finally, we create a MoS2 transistor with a channel length of ~ 13 nm, exhibiting an on/off of over 108 and SS of 70 mV dec− 1. The successful integration of ferroelectric, high-κ HZO as a top gate material effectively addresses current challenges and paves the way for the advancement of 3D integrated circuits utilizing 2D materials.
Test Validity of The Wijma Delivery Expectancy/Experience Questionnaire for Pregnant Women in Indonesia: A Pilot Study
Authors: Kurniawati Wiwit , Abdullah Khatijah Lim , Lantu Nurlela , Santi Neni Fidya , Astuti Yunita Laila , Faradiena Fayna , Kusumaningrum Arie
Published: May 2024

Background: Fear of childbirth (FOC) become a common psychological health problem for pregnant women. The Wijma Delivery Expectancy/Experience Questionnaire (WDEQ) is a common tool for assessing FOC which had, not yet been validated in Indonesia. This study aimed to evaluate the psychometric properties of the W-DEQ in Indonesia.
Methods: A cross-sectional study was conducted among 105 pregnant women at a Public Health Center in Indonesia. The Confirmatory Factor Analysis (CFA) was applied to test the construct validity of the W-DEQ.
Results: The mean age of participants was 29.64 years (SD = 4.85) and their pregnancy age mean was 28 weeks (SD = 8.51). Confirmatory factor analysis of the Indonesian version of the W-DEQ indicated a unidimensional (one-factor) structure with bifactor which indicated that this instrument besides measuring FOC, also indicates another factor (self-confidence and negative expectation). The Comparative Fit Index/CFI (0.939) and the Tucker-Lewis Index/TL (0.930) goodness of fit indices non-parametric were obtained, showing that the final model (23 items) of W-DEQ is acceptable with a note of improvement on some items.
Conclusions: The Indonesian version of W-DEQ is a valid tool for screening and assessing mothers’ childbirth fear among Indonesian women in this pilot study. However, adjustments need to be made to apply this instrument on a national scale.
A mutual AKE protocol on the SIS problem
Authors: Yan Yang , zhou limin
Published: May 2024

In the quantum era, the key exchange protocol with mutual authentication pays an important role for communication parties to establish the shared session key, and the security of protocols is gradually being emphasized. Based on previous results,we build a simple mutual AKE protocol on the SIS problem and prove its security in the ROM. In addition, due to matrix-vector multiplication instead of exponentiation, it has less computation, and communication cost is less thank to lack of symmetric encryption/decryption as well as less storage and implementation cost in contrast with existed method and it has high practicality.
Mathematics Subject Classification (2000) 06D50
Backbone and methyl side-chain resonance assignments of the Fab fragment of adalimumab
Authors: Sarker Muzaddid , Aubin Yves
Published: May 2024

Adalimumab is a therapeutic monoclonal antibody developed to target human TNF an important mediator of immune-mediated inflammatory diseases such as rheumatoid arthritis, amongst others. The 48 kDa Fab fragment of adalimumab was produced in Escherichia coli using a single chain approach to allow complete isotopic incorporation of deuterium, carbon-13 and nitrogen-15 along with the protonated isoleucine-d, valine and leucine methyl groups. Here we report the near complete resonance assignment of the polypeptide backbone and the methyl groups of isoleucine, leucine and valine residues.
The efficacy of two kinds of scissor-type knives for colorectal endoscopic submucosal dissection: A retrospective comparative study
Authors: Shen Jianhua , Yoshida Naohisa , Kobayashi Reo , Inoue Ken , Hirose Ryohei , Dohi Osamu , Konishi Hideyuki , Tomita Yuri , Itoh Yoshito
Published: May 2024

Introduction:
Scissor-type knives are spreading as safe devises in endoscopic submucosal dissection (ESD). We evaluated the efficacy of two kinds of scissor-type knives (Clutch Cutter: CC, Fujifilm and SB knife Jr2: SB, SB-Kawasumi) in colorectal ESD.
Methods
This single-center retrospective study analyzed 178 ESD cases treated with CC from January 2020 to August 2021 and 91 cases with SB from September 2021 to December 2023. The two groups were compared through propensity score matching. Therapeutic results, such as ESD procedure time, en bloc resection rate, perioperative bleeding frequency, and complications, were analyzed in each group. Risk factors for long ESD procedure time (≥ 90 min) were also examined.
Results
After matching, 87 cases in each group were analyzed. There was no significant difference in the ESD procedure time (min, median [interquartile range]) between the CC and SB groups (54 [36–72] vs. 53 [39–72], p = 0.99). Additionally, there were no differences in the en bloc resection (100% vs. 100%, p = 1.00), perioperative perforation (1.1% vs. 1.1%, p = 1.00), or delayed bleeding (1.1% vs. 0.0%, p = 1.00). There was a significant difference in perioperative bleeding frequency (mean ± standard deviation: 1.8 ± 2.6 vs. 3.0 ± 3.5, p < 0.01). The significant risk factors (odds ratio [95% confidence interval]) for long ESD procedure time in patients treated with CC or SB were antiplatelet (7.51 [1.82-31.00]), large lesion size (1.08 [1.05–1.12]), severe fibrosis (24.30 [7.60–77.90]), and perioperative bleeding frequency (1.34 [1.14–1.56]).
Conclusions
CC and SB in colorectal ESD enabled high en bloc resection and low complication rates. CC showed significantly less perioperative bleeding than SB.
Genomics of the TGF-beta subfamily in Cancer
Authors: Choudhury Shouhartha
Published: May 2024

The transforming growth factor-beta (TGF-β) subfamily regulates a magnificent spectrum of cellular processes and controls diseases, including cancer. The unique components of TGF-β had duplex roles in tumorigenesis. In tumorigenesis, TGF-beta has a tumour suppressive response observed by cell cycle block and cell death. So, TGF-β reveals a driving force of tumour elongation and metastasis by cumulative tumour cell interference and migration to promote therapeutic resistance. In this outlook, the study objected to identifying the TGFB domain-mediated gene in two mammalian genomes. So, perform bioinformatics and computational techniques to the current wisdom of the TGF-beta subfamily in two genomes. Primary observation demonstrated that the composition of nucleotides and peptides in the TGF-beta 1 gene in Homo sapiens. Also, the investigation forwarded the sum of TGFB domain-mediated genes in the TGF-beta subfamily in both organisms. Further analysis of TGF-beta 1 (target sequence), a unit of the TGF-beta subfamily, demonstrated the 3D structure, conserved domain, sequence motifs, phylogeny, gene expression and gene network, chromosome location, and pathways. Hence, the study outcome and proof of the molecular functions and mechanisms confirmed that the TGF-beta subfamily plays a fundamental role during tissue homeostasis in organisms.
Field application of tea volatiles mediating host selection of Aleurocanthus spiniferus
Authors: Jia Zhi-Fei , Huang Li-Yun , Bian Ya-Nan , Song Kai , Li Dan-Dan , Li Zhao-Qun , Xu Yong-Yu , Chen Zhen-Zhen
Published: May 2024

Aleurocanthus spiniferus is a major pest of tea trees; both nymphs and adults suck plant sap and induce tea sooty mould. Pest occurrence varies significantly among different tea cultivars, even within the same plantation environment. It was speculated that adult A. spiniferus may be differentially attracted by different cultivars. This study aims to identify the bioactive components in tea volatiles that mediate host selection of A. spiniferus and to utilize them for effective field trapping. Through field investigations and Y-tube olfactometer tests, we identifiedtwo highly preferred tea cultivars (‘Huangjinya’ and ‘Fuding white tea’) and two cultivars (‘Baiye No. 1’ and ‘Longjing 43’) that were not. Behavioral assays and gas chromatography-mass spectrometry (GC-MS) analysis identified four attractive compounds [hexanol, (E)-2-hexenal, linalool, and (E,E)-α-farnesene] and two repellent compounds [nonanal and (Z)-3-hexenol] from tea volatiles of the four. Among these compounds, four [nonanol, (Z)-3-hexenol, linalool and (E,E)-α-farnesene] were able to elicit obvious electrophysiological (EAG) response at 100 μg/μL. In field trials, the synergistic bait trap equipped with two types of attractants, blend 4 [the mixture of linalool and (E,E)-α-farnesene] at 100 μg/μL and blend 6 [the mixture of linalool and (Z)-3-hexenol] at 100 μg/μL, had a significant attractant effect with a long effective period. Two synthetic mixtures of tea volatiles, blend 4 and blend 6, had the potential to be developed as commercial plant-based attractants for adult A. spiniferus. This study contributes to the development of sustainable, environmentally friendly management strategies for a pest that is difficult to prevent and control.
Threatened saproxylic beetle species in tree hollows react more sensitively to surrounding landscape composition in central European managed forests than total species richness
Authors: Henneberg Benjamin , Feldhaar Heike , Förtsch Sebastian , Schauer Bastian , Obermaier Elisabeth
Published: May 2024

1. Veteran deciduous trees are a rare element in today’s central European managed forests due to intensive forest management over the last 200 years, resulting in a loss of dead wood habitats like tree hollows. Saproxylic beetle species depend on dead wood, and habitat specialists, such as species relying on tree hollows, are largely threatened. 2. To better understand how to protect saproxylic beetle assemblages in tree hollows at a landscape scale we collected beetles from tree hollows in three forest regions in Bavaria using emergence traps. We related landscape composition at spatial scales of 300–5000 m around the tree hollows to beetle diversity in the hollows using CORINE satellite data. We also modelled four dispersal-associated morphological traits as well as functional diversity indices of the beetles in relation to landscape composition. 3. The proportion of deciduous forest surrounding the tree hollows had positive effects on species richness of saproxylic beetles in two of the three study regions. Positive effects on threatened species were more pronounced than effects on total species richness at all spatial scales. Relationships between functional diversity and landscape composition only partly confirmed our expectations regarding better dispersal ability of beetles in isolated habitat patches. 4. Our study indicates that threatened saproxylic beetles react more sensitively to landscape compositional changes than common species. In the light of ongoing habitat fragmentation, efforts to protect threatened saproxylic beetle species should not only include single forest stands but focus on a landscape scale and support connectivity of forest patches.
A facile strategy to reinforce styrene-butadiene rubber with modulus domain
Authors: Ran Lijun , Wang Xiaoping
Published: May 2024

The incorporation of fillers into the elastomer matrix is universally acknowledged as an effective strategy for fabricating superior-performance rubber materials, which depends on filler dispersion and interfacial interaction. In this work, styrene-butadiene rubber (SBR) with high modulus domains were prepared via the in situ reaction of epoxy resin (E51) and 4,4'-diaminodiphenylmethane (DDM) and a satisfactory mechanical properties reinforcement effect. The crosslinked network was confirmed by high-temperature infrared spectroscopy, vulcanization properties and activation energy. Scanning electron microscopy (SEM) demonstrated that the dispersed phase formed by the in situ reaction of E51 with DDM was uniformly dispersed in the matrix. Furthermore, with the loading of E51 from 5 phr to 15 phr, Atomic force microscopy (AFM) further confirmed that the size of the dispersed phase increased from 400 nm ~ 1 µm to 750 nm ~ 2 µm, and that the dispersed phase formed a high-modulus “domain” with low adhesion in the matrix, and the modulus increased from 90.1 MPa to 279.3 MPa, whereas the modulus of the SBR matrix was maintained at 11 ~ 15 MPa, and there was an interfacial layer with a thickness of 304 nm ~ 470 nm between the domain and the SBR matrix. At E51 loading of 15 phr, the 300% modulus, strength and fracture toughness of the specimen was significantly increased to 3.58 MPa, 6.34 MPa and 17.41 MJ/m3, respectively, which were 2.50, 3.30 and 3.03 times higher than those of SBR. The approach suggested in this research introduces an innovative method for reinforcing unfilled rubbers.
Clinical significance of cerebral microbleeds in patients with germinoma who underwent long-term follow-up
Authors: Kanamori Masayuki , Mugikura Shunji , Iizuka Osamu , Mori Naoko , Shimoda Yoshiteru , Shibahara Ichiyo , Umezawa Rei , Jingu Keiichi , Saito Ryuta , Sonoda Yukihiko , Kumabe Toshihiro , Suzuki Kyoko , Endo Hidenori
Published: May 2024

Purpose
This study identified the factors affecting cerebral microbleed (CMBs) development. Moreover, their effects on intelligence and memory and association with stroke in patients with germinoma who had long-term follow-up were evaluated.
Methods
Patients histologically and clinically diagnosed with and treated for germinoma were included in this analysis. These patients were evaluated cross-sectionally, with a focus on CMBs on susceptibility-weighted magnetic resonance imaging (SWI) and intelligence and memory.
Results
The follow-up period was from 32 to 412 (median: 175.5) months. In total, 46 (72%) patients had CMB. The total number of CMBs was 523 (8.1 per patient). Patients with recurrence had a significantly higher number of CMBs based on analysis of covariance adjusted for intervals from the initial treatment to the acquisition of magnetic resonance imaging images. ༴he patients were classified into the CMB-high and CMB-low groups with the median number of CMB. Patients with a high CMB had a lower processing speed score than those with a low CMB. Before SWI acquisition and during the follow-up periods, eight strokes occurred in four patients. Greater than 15 CMBs were found on SWI in all four patients. Meanwhile, 51 patients with < 14 CMBs did not experience stroke.
Conclusion
Patients with a longer time from treatment initiation had a high number of CMBs. Further, the number of CMBs increased over time, and recurrence was a significant risk factor of CMB development. Finally, the increased number of CMBs was related to the decline in process speed and stroke onset.
Transcriptome sequencing reveals differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome
Authors: wang nan , Gao Yongheng , Xue Peini , Ma Ruina , Li Yanyan , Liu Wei
Published: May 2024

Object:
To discover the mechanism underlying the role of circulating RNA (circRNA) in pulmonary microvascular permeability in acute respiratory distress syndrome (ARDS).
Methods
We developed an in vitro model of ARDS using cultured human pulmonary microvascular endothelial cells (HPMECs) and lipopolysaccharide challenge. Genome sequencing showed significant differences among cells in the expression of circRNA. GO and KEGG analysis of target genes were conducted. The circRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) network was constructed. GO enrichment of target genes in the ceRNA network was analyzed.
Result
Genome sequencing results showed that a total of 379 significantly up-regulated and 448 significantly down-regulated circRNAs. The 10 circRNAs with the greatest degree of up-regulation and the 10 circRNAs with the greatest degree of down-regulation were identified. The results of GO enrichment analysis indicated that differential circRNA expression may mediate the cellular response to DNA damage, including DNA repair. The results of KEGG analysis indicated that the mechanism by which differential circRNA expression exerts these effects may involve the MAPK signaling pathway. GO enrichment analysis of target genes in the ceRNA network showed that the circRNAs were mainly involved in the fluid shear stress response, angiogenesis regulation, vascular development, and cell adhesion.
Conclusion
Differential expression of circRNAs may play an important role in ARDS, especially in the control of HPMEC permeability. The circRNAs found to have differential expression in response to DNA damage may also be used as biomarkers for early prediction of ARDS disease.
Green and Sustainable Bamboo Leaf Ash Derived WO 3 Impregnated Mesoporous KIT-6 Catalyst for Acetalization of Glycerol to Biofuel Additives: Activation Energy Calculation
Authors: Shanmugam Manimaran , Arumugam Pandurangan
Published: May 2024

Utilizing surplus glycerol from biodiesel production for dioxolane synthesis, a significant fuel enhancer, is pivotal. We developed mesoporous spherical KIT-6 supported WO3 using sodium silicate derived from bamboo leaf ash (BLA) and ammonium tungstate hydrate. Characterization via XRD, N2 adsorption-desorption, SEM, TEM, NH3-TPD, and XPS confirmed KIT-6's phase purity. WO3 impregnation on BLA-KIT-6 notably improved glycerol conversion and dioxolane selectivity compared to amorphous KIT-6 from tetraethyl orthosilicate (TEOS), primarily due to its advantageous spherical morphology. Spherical structures typically offer higher surface areas, facilitating more active sites for acid catalysis and thereby enhancing acidity. Additionally, glycerol conversion and dioxolane selectivity over the WO3/BLA-KIT-6 catalyst were higher with p-nitrobenzaldehyde due to its -M effect, while long chain aldehydes exhibited reduced conversion due to their + I effect. Conversely, cyclic ketones displayed heightened reactivity in glycerol acetalization over WO3/BLA-KIT-6 catalyst. Catalyst recyclability and hot-filtration tests verified its stability and heterogeneity. The Arrhenius plot yielded an apparent activation energy of 37.098 kJ/mol for the WO3/BLA-KIT-6 catalyst.
On the heat recovery of the spray dryers by using the tube-finned heat exchanger with elliptical holes
Authors: Moghaddam Hossein Reza , Javaherdeh Kourosh
Published: May 2024

In this paper, the applicability of the heat exchangers for the heat recovery and energy saving purposes in spray dryers by utilizing Computational Fluid Dynamics (CFD) is investigated. For this purpose, two different tube-finned heat exchangers with the elliptical holes are added to the equipment. The first one gives the heat of the exhaust air and the second one translates the recovered heat from the exhaust air to the atomizing air. Initially, the effect of different parameters on the heat exchangers are studied. Then, numerically the effect of adding heat exchanger on the factory performance is evaluated. It is observed that by adding the mentioned heat exchangers, the energy consumption and energy price of the factory and the spray dryer decreases. Hence, the suggested equipment can be used for energy saving in the spray dryers.
Development of the Theory-Based Exercise Education and Prescription Smartphone Application for Sedentary Individuals: A Randomized Controlled Trial
Authors: GÜR Fatih , Ayan Vedat
Published: May 2024

Introduction: This study aims to develop and test a Cognitive-Behavioral Theory (CBT) based mobile application in accordance with the evidence-based physical activity recommendations in order to improve the health-related physical fitness parameters of university students with inadequate levels of physical activity.
Methods: Participants were selected from students at … University, who did not meet the lowest level of physical activity recommended by the World Health Organization and the American College of Sport Medicine for healthy adults for the past 6 months. Experimental research design with randomized control group was used in the study. Participants were randomly distributed into the experimental (n=63) and control groups (n=62). Participants in the experimental group performed an average of 40 minutes of aerobic, strength and flexibility exercises 4 days a week for 8 weeks, using the Exercise Education and Prescription (ERVE) mobile application, developed within the scope of the research. They also received CBT-based exercise education through the ERVE application. Participants were evaluated for health-related physical fitness parameters before and after the study.
Results: As a result of the 8-week application through ERVE, the maximum oxygen consumption, maximum push-ups, maximum sit-ups, hand grip strength and body flexion values of the participants in the experimental group was found to statistically significantly differ than that of the control group (p<0.05).
Conclusions: As a result, the ERVE mobile application can help university students with insufficient levels of physical activity increase their physical activity levels and improve some of the health-related physical fitness parameters.
Unraveling Proteomic Adaptations to Moderate Heat Stress in Arabidopsis thaliana: Insights for Developing Thermotolerant Crops
Authors: Fan Kai-Ting , Xu Yuan
Published: May 2024

The imminent danger of global warming jeopardizes plant survival, leading to negative consequences for growth and agricultural productivity. A thorough understanding of how plants respond to heat stress at the molecular level is essential for the development of thermotolerant crops. To delve into this intricate mechanism, we embarked on exploring proteome dynamics in Arabidopsis thaliana seedlings under moderate heat stress conditions (30°C), employing an innovative blend of 15N-stable isotope labeling and the ProteinTurnover algorithm. This method enabled a meticulous examination of proteomic alterations across various cellular fractions. Our investigation unearthed significant turnover rate changes in 571 proteins, with a median increase of 1.4-fold, reflecting accelerated protein dynamics during heat stress. Notably, root soluble proteins displayed subtler changes, hinting at tissue-specific adaptations. We also observed remarkable turnover variations in proteins associated with redox signaling, stress response, and metabolism, underscoring the intricate nature of the response network. Conversely, proteins involved in carbohydrate metabolism and mitochondrial ATP synthesis exhibited minimal turnover changes, indicating their stability. This comprehensive analysis provides insights into the proteomic adjustments of Arabidopsis seedlings to moderate heat stress, shedding light on the delicate balance between proteome stability and adaptability. These findings significantly contribute to our understanding of plant thermal resilience and offer valuable support for the development of crops endowed with enhanced thermotolerance.
Fusion of Multiple Self-Diagnostic Questionnaires into Optimal Diagnostic Cut-offs and Factor Analysis for Depression Characterization of the Korean University Student Group
Authors: Lee Soojin , Lee Sukhan , Lee Jungsun , Jo Youngtak , Park Eunil , Cha Junyeop
Published: May 2024

Background: The diagnostic cut-offs and factor analysis prepared for a general population by depression self-questionnaires are inadequate for a focused population with its cultural background. Therefore, we present a novel approach to optimizing diagnostic cut-offs and generalizing factor analysis for the Korean university student group in the fusion space of multiple self-questionnaires.
Methods: We collected the data from 30 randomly selected Korean university students, over 21 weeks, with the psychiatric evaluation as a reference, then established the optimal cut-off regions in the fused CESD−­PHQ9 score space based on the statistical correlation between CES−D and PHQ−9 and the reference diagnostics. We also re-extracted the factors in the fused CESD−PHQ9 space to expose the key factors that are behind the depression characteristics of the group.
Results: The proposed approach is population-specific cut-off regions, which can provide more reliable and trustworthy diagnoses. On the extended factor analysis, we identified the major factors of the depression characteristics of the group to be the “socio-psychological” and “interpersonal relationship” associated with academic studies and employment.
Limitations: Since there is a lack of evaluation of the accuracy of the proposed approach with the clinical diagnosis, whether it can effectively fulfill the role of intermediate diagnosis between patients and psychiatrists needs to be verified.
Conclusion: We identified optimal cut-off regions and generalized factor analysis in the fusion space. Finally, these can serve as a self-diagnostic tool for reliably identifying the depression characteristics of a focused population as well as effectively linking individuals and psychiatrists as an intermediary.
The nucleus reuniens drives hippocampal goal‑directed trajectory sequences for route planning
Authors:   , Kim Hye-A
Published: May 2024

Goal-directed spatial navigation requires accurate estimates of one’s position and destination, as well as careful planning of a route between them to avoid known obstacles in the environment. Despite its general importance across species, the neural circuitry supporting the ability for route planning remains largely unclear. Previous studies described that place cells in the hippocampal CA1 encode the animal's next movement direction (Wood et al., 2000; Ito et al., 2015) and upcoming navigational routes (Pfeiffer & Foster, 2013). However, it has been shown that part of the CA1 activity representing the animal’s future behaviors is not necessarily generated in the hippocampus, but is derived from the medial prefrontal cortex (PFC) via the nucleus reuniens of the thalamus (RE) (Ito et al., 2015). Notably, the importance of the PFC in navigation has been demonstrated in several studies, including the recent finding of a goal map in the orbitofrontal cortex (Basu et al., 2021). Therefore, I hypothesized that information flow from the PFC to CA1 via the RE plays a key role in route planning. To assess the animals' route planning ability, I designed a new navigation task in which a rat has to navigate to a fixed target location from various starting positions in an arena. Furthermore, by adding an L-shaped wall in the maze and removing all light sources in the experimental room, this task forced the animals to plan a wall-avoiding route without relying on direct sensory perceptions. I confirmed that rats could learn this task successfully, memorizing the wall location and taking a smooth wall-avoidance route. To test the role of the RE, I inactivated RE neurons by expressing the inhibitory opsin SwiChR++, which resulted in a significant deficit in the animal’s route planning ability, taking a longer non-smooth path to the destination. By contrast, this manipulation did not affect navigation performance when a straight goal-directed route was available, suggesting a specific role of the RE in route planning. I further found that DREADDs-mediated inactivation of neurons in the bilateral hippocampi resulted in a similar deficit in route planning ability, implying cooperation between the RE and the hippocampus. I finally examined the activity of hippocampal CA1 neurons with and without RE inactivation. While neurons in the hippocampus exhibited brief trajectory sequences corresponding to the animal’s subsequent goal-directed journey, I found that this goal-directed bias of trajectory events was significantly reduced by RE inactivation, likely associated with route-planning deficits in these animals. Altogether, this dissertation demonstrates the role of the RE from both behavioral and neural coding perspectives, identifying a pivotal circuit element supporting the animal’s route-planning ability.
Sistem Check-In Di Lingkungan Sma Budya Wacana Dengan Memanfaatkan Qr Code Dan Geolokasi
Authors: Gozales Ferdinand , Maria Nila Anggia Rini  , Lukas Chrisantyo
Published: May 2024

Technology began to develop rapidly at that time. Many tools have been invented to facilitate human work, one of which is the Quick Response Code. QR codes are two-dimensional matrix codes or barcodes created to allow scanners to respond quickly and receive data quickly. QR codes can be used to manage the attendance of students, teachers, and school staff. This study defines a QR code work system for student, teacher, and staff badges to manage student, teacher, and staff activity data and keep track of all students attending school. employee activities. This study uses the Waterfall System Development Life Cycle method. The key component of the system is a webcam scanner that reads QR codes filled with master keys for student, teacher, and staff data. Attendance plays an important role in all institutions. This can lead to errors on the part of the school or students. For example, inefficient use of paper, absenteeism, missing monthly reports, missing wastepaper, etc. In addition, handwritten attendance carries the risk of absenteeism due to corruption of attendance data, which can lead to carelessness by employees and students.
 
Intisari— Teknologi saat itu mulai berkembang pesat. Telah banyak ditemukan alat untuk mempermudah pekerjaan manusia, salah satunya adalah Quick Response Code. Kode QR adalah kode matriks atau barcode dua dimensi yang dibuat untuk memungkinkan pemindai merespons dengan cepat dan menerima data dengan cepat. Kode QR dapat digunakan untuk mengelola kehadiran siswa, guru, dan staf sekolah. Studi ini mendefinisikan sistem kerja kode QR untuk lencana siswa, guru, dan staf untuk mengelola data aktivitas siswa, guru, dan staf serta melacak semua siswa pergi ke sekolah. aktivitas karyawan. Penelitian ini menggunakan metode Waterfall System Development Life Cycle. Komponen kunci dari sistem ini adalah pemindai webcam yang membaca kode QR yang diisi dengan kunci utama untuk data siswa, guru, dan staf. Kehadiran memainkan peran penting di semua institusi. Hal ini dapat menimbulkan kesalahan dari pihak sekolah atau siswa. Misalnya, penggunaan kertas yang tidak efisien, ketidakhadiran, laporan bulanan yang hilang, dan kertas bekas yang hilang. Selain itu, presensi tulisan tangan memiliki risiko presensi karena rusaknya data presensi yang dapat menimbulkan
Penerapan Sistem Rekomendasi Registrasi Mata Kuliah Informatika UKDW
Authors: Kristian Hartono Renaldi , Mahastama Aditya Wikan , Lukito Yuan
Published: May 2024

Setiap tahun ajaran baru dimulai, prodi Informatika UKDW akan menyediakan mata kuliah yang dapat dipilih mahasiswa saat melakukan registrasi. Mata kuliah yang disediakan ini pada dasarnya dibagi menjadi mata kuliah wajib dan mata kuliah pilihan. Berdasarkan 2 macam mata kuliah ini, bagi Mahasiswa Informatika terutama dalam memilih mata kuliah pilihan seringkali disesuaikan dengan bidang minat dari masing-masing mahasiswa. Bidang minat ini yang kemudian disesuaikan dengan mata kuliah yang ada pada saat registrasi, namun walaupun demikian bagi Mahasiswa Informatika sering mengalami kebingungan dalam memilih mata kuliah pada saat registrasi.

 

Oleh sebab itu penelitian ini akan merancang sebuah sistem rekomendasi mata kuliah yang digunakan untuk membantu merekomendasikan mata kuliah kepada Mahasiswa Informatika UKDW sebelum melakukan registrasi. Terdapat 2 mesin yang digunakan sistem dalam memproses rekomendasi yaitu Python dan Laravel. Proses rekomendasi yang dilakukan oleh Python akan menggunakan Item-Based Collaborative Filtering yang memiliki proses diantaranya mengumpulkan data berupa hasil rating mata kuliah, memproses similarity antar mata kuliah untuk tiap bidang minat, serta menghitung matriks evaluasi dengan menggunakan MAP. Kemudian hasil dari similarity yang paling tinggi akan digunakan sebagai kriteria untuk menampilkan rekomendasi menggunakan Laravel.

Sistem dilakukan uji coba dengan 10 testcase berupa skenario mahasiswa dari angkatan 2021, 2020 dan 2019. Hasil testcase menunjukkan mata kuliah yang seharusnya diambil mahasiswa, sedangkan evaluasi terkait dengan hasil mata kuliah yang direkomendasikan sistem. Hasil evaluasi testcase dinyatakan memiliki tingkat keberhasilan 80% berdasarkan 8 dari 10 testcase yang berhasil. Selanjutnya sistem memiliki tingkat keakuratan untuk mata kuliah bidang minat sebesar 46.36% yang dihitung menggunakan metode Mean Average Precision (MAP) dengan melakukan rata-rata berdasarkan presisi dari 10 testcase. Presisi dihitung dalam dengan cara membandingkan mata kuliah bidang minat yang telah direkomendasikan dengan mata kuliah bidang minat yang telah diambil pada tiap testcase.
Enhancement of Indonesia’s blue economy sector through innovation and competitive advantage based on Resource-Based View theory
Authors: Rianawati Andri , Kresna Darmasetiawan Noviaty , Susilo Hadi Faizal , Oktavianus Joshua , Avelinda Utama Carissa
Published: May 2024

Indonesia’s blue economy holds immense potential due to the marine ecosystem and maritime area, encompassing the marine fisheries sector, marine tourism, and fisheries influencing the market. Despite this significant potential, these resources have not been optimally utilized to boost economic growth. Therefore, this study aims to investigate the competitive advantage of the Blue Economy sector by enhancing the outcomes of the tourism, processing, and sales of fisheries in Indonesia through the Resource-Based View (RBV) theory. The Resource-Based View theory explains the formulation and creation of competitive advantages by utilizing tangible and intangible resources such as innovation, strategy, capability, and culture. This study employs a quantitative method through an online survey with a total of 319 respondents working in the Blue Economy sector, including fisheries, marine product sellers, and marine tourism. The analytical methodology uses Structural Equation Modeling (SEM) with SMART PLS to assess the determination of competitive advantage. The findings of this study show that capabilities, operational capabilities, response capabilities, technological capabilities, innovation culture, innovation strategy, and strategic alignment significantly influence competitive advantage. Moreover, the competitive advantage in the blue economy sector is most influenced by innovation strategy with a beta of 0.375. This suggests that enhancing innovation strategies can positively impact Indonesia’s fisheries industry, as evidenced by fisheries tourism being the largest tourism sector in Indonesia, competing with international tourism. Additionally, Indonesia’s fisheries sector is a major contributor to exports.
Acknowledgment The authors would like to thank all the stakeholders, including entrepreneurs, government officials, and academics, for their willingness to provide in-depth information on maritime matters in North Sulawesi and other assistance essential for the success of this study.
The effectiveness of minimally invasive surgical techniques for treating patients with chronic venous insufficiency in the stage of trophic disorders: comparative study
Authors: Khitaryan A. G. , Veliev K. S.
Published: May 2024

Introduction. Despite the active introduction of minimally invasive techniques into modern phlebology, the problem of surgical treatment of chronic venous insufficiency (CVI) in the stage of trophic disorders is still far from being finally resolved, especially problems of horizontal reflux. Aim. Тo comparatively evaluate the results of using various tactics of minimally invasive surgical treatment in patients with lower extremitiesʹs CVI in the stage of trophic disorders.

Materials and methods. A study at 139 patients with CVI at the stage of trophic disorders was carried out. Group 1 (n = 79) included patients who underwent endovasal laser coagulation of the trunks of the great and small saphenous veins (GSV and SSV) with microfoam sclerotherapy of varicose perforating veins. In group 2 (n = 60) – method of intervention was determined by the diameter of Cockettʹs perforants.

Results. Indicators of the early postoperative period in the study groups were comparable. After 2 months, no cases of relapse in the GSV and SSV were registered. Recurrence of horizontal reflux was observed only in 6 (7.6%) people in group 1. In long-term postoperative follow-up, decrease in the severity of the disease according to the VCSS scale was found in both groups (p < 0.001). The persistence of pathological reflux along was observed in 16 (22.5%) patients of group 1. Moreover, in 62.5% and 68.75% cases of relapses, the perforants had, respectively, a large diameter and high blood flowʹs speed.

Discussion. In general, minimally invasive techniques used demonstrated comparable clinical results and high efficiency. At the same time, the importance of preoperative assessment and taking into account the properties of perforants has been proven.

Conclusion. The claimed method should be considered as an effective and safety method of obliteration of incompetent perforating veins at severe forms of CVI.
Identification of relapse predictors of IgG4-related sclerosing cholangitis
Authors: Guseva A. K. , Okhlobystin A. V.
Published: May 2024

Introduction. Relapses occur in 30–50% of patients IgG4-related sclerosing cholangitis. Relapses may act an independent risk factor for malignancy development and the need in maintenance therapy for relapse prevention is still uncertain. Thus, studying relapse predictors and developing reliable preventive approaches is an important area of research for this condition.

Aim. To determine relapse predictors of IgG4-related sclerosing cholangitis.

Materials and methods. A single- center dynamic bidirectional observational study was conducted in patients aged 18 years and older with verified IgG4-related sclerosing cholangitis (n = 32). We searched for possible factors influencing the relapse of IgG4- related sclerosing cholangitis. The development of a prognostic model for the relapse probability was carried out using logistic regression. ROC analysis was used to assess the diagnostic performance of quantitative variables in predicting of relapse.

Results. The median follow-up period was 33 (16–60) months. The majority of patients with IgG4-related sclerosing cholan- gitis were male (71.9%), median age was 59 ± 13 years. In most patients, delayed diagnosis (median 10.5 [4.8; 22.5] months) was associated with overdiagnosis of primary sclerosing cholangitis (41.2%) or bile duct malignancy (43.8%). Surgical interventions were performed in 50% of patients. Median serum IgG4 level was 2.70 g/L [1.92; 6.48], and 21.9% of patients had normal serum IgG4 level. Disease relapse developed in 34.4% (n = 11) of patients. Serum IgG4 level before glucocorticosteroid therapy ≥ 2.24 g/L and a delay in diagnosis by ≥ 17 months were associated with the relapse (p = 0.040 and p = 0.049 respectively). Multi-organ involvement, and extrahepatic localization of biliary strictures in the patients with the history of surgical interventions increased the risk of relapse 85 (p = 0.001) and 12 (p = 0.047) fold, respectively. The presence of biliary strictures below the confluence reduced the risk of relapse 7.5 fold (p = 0.032).

Conclusions. Possible predictors of IgG4-related sclerosing cholangitis relapse may include multi- organ involvement, intrahepatic and proximal extrahepatic strictures, prior surgical interventions in patients with extrahepatic strictures, high serum IgG4 level, and delayed diagnosis.
Oil emulsion stability in electrolyzed water solutions
Authors: Pogorelov Alexander , Ipatova Larisa , Panait Artem , Stankevich Anna , Pogorelova Valentina , Suvorov Oleg
Published: May 2024

Metastable electrochemically-activated water solutions possess unique properties that make it possible to modify food emulsions. This comparative analysis featured the stability of model oil-in-water emulsions with anolyte or catholyte as a dispersion medium, as well as the physical and morphometric profile of the emulsion system.
The research involved emulsions based on anolyte and catholyte. They consisted of refined sunflower oil, emulsifier (lecithin), and stabilizers, which were represented by sodium alginate, sodium carboxymethylcellulose, pectins, and agar. The study also covered such parameters as aggregative stability, viscosity, morphometry, oil particle size, and zeta potential.
Anolyte and catholyte affected the process of separation in the model emulsions. The samples stabilized with alginate and sodium carboxymethylcellulose proved to be the most stable emulsions while agar triggered gelation. The effect of substituting tap water with metastable electrolyzed water solutions depended on the oil proportion in the emulsion. Catholyte destabilized the samples with 20% of oil and liquified gel in the samples stabilized with agar. Anolyte was more aggressive in destabilizing emulsions with 30% of oil. The effective viscosity of these emulsions correlated with the stable phase fraction. The anolytebased samples had low effective viscosity. The opposite results for emulsions with different oil fractions may have been caused by interface changes, i.e., surface tension, adsorption, coalescence, etc. In the emulsions with 46% of oil and animal origin emulsifier, neither anolyte nor catholyte had any significant effect on the aggregative stability of the system.
The revealed patterns can be used to control the properties of emulsion products with oil phase ≤ 30%, e.g., low-fat mayonnaises, sauces, emulsion drinks, etc. Metastable electrolyzed water solutions may provide a reagent-free control of properties and patterns of finished or semi-finished foods and biological raw materials.
Presencia del briozoo exótico Amathia verticillata (Delle Chiaje, 1822) (Ctenostomatida: Vesiculariidae) en la costa del País Vasco (SE del golfo de Vizcaya)
Authors: Martínez Julián , Adarraga Idoia
Published: May 2024

Amathia verticillata (Delle Chiaje, 1822) se cita por primera vez en la costa del País Vasco. Las colonias de este briozoo exótico fueron encontradas en áreas intermareales de la isla de San Nikolas y puerto de Lekeitio (Bizkaia, SE del golfo de Vizcaya). En el presente artículo se aporta una descripción morfológica de las colonias, así como una discusión sobre el origen, vía de entrada y posibles impactos ecológicos y económicos en la zona.
biblioteca escolar
Authors: Pereira Gleice , Moreira Wallace Bertoli
Published: May 2024

Este estudo tem como tema a biblioteca escolar, vista como um espaço pedagógico que promove a vivência empática, analisado em uma perspectiva antropológica e fenomenológica. A justificativa se baseia na dimensão pedagógica e antropológica da biblioteca escolar, que tem a pessoa humana como centro de seus processos e possibilita a reflexão sobre a experiência no mundo social e cultural, bem como a manifestação da intersubjetividade humana. O objetivo geral foi compreender a empatia como ato pedagógico vivenciado na biblioteca escolar, a partir de um viés fenomenológico, e considerando a Base Nacional Comum Curricular (BNCC) e a Antropologia Filosófica. A pesquisa foi de natureza teórica, bibliográfica, exploratória e descritiva e se delimitou no conceito de empatia na Antropologia Filosófica e na BNCC, com a finalidade de problematizar e investigar se a vivência empática pode contribuir para o ato pedagógico na práxis cotidiana da biblioteca escolar. Os resultados apontaram que a biblioteca escolar, ao aplicar a vivência empática em sua dimensão pedagógica mediadora, revela a sua concepção antropológica e se constitui como um lugar privilegiado para o ato educativo empático, a pedagogia humanizadora, o diálogo, a reflexão sobre o outro, a promoção do respeito e dos direitos, a formação cidadã, o acolhimento à diversidade social e cultural, a abertura para a subjetividade e as relações intersubjetivas humanas.