bluuebunny/crossref_metadata_2025 huggingface dataset:
Pyrido[2,3‐d]pyrimidines and Pyrimido[5′,4′:5,6]pyrido[2,3‐d]pyrimidines as New Antiviral Agents: Synthesis and Biological Activity.
Authors: Nasr Magda N. , Gineinah Magdy M.
Published: May 2010

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Cytotoxic Activity of Esters and Nitriles of 1,3,5‐Triazinyldinitrobutyric Acids.
Authors: Gidaspov A. A. , Bakharev V. V. , Kachanovskaya E. V. , Yakunina N. G. , Bulychev Yu. N.
Published: May 2010

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Antibacterial Activity of 3‐(5‐Methylisoxazol‐3‐yl)‐1,2,4‐triazolo[3,4‐B]‐1,3,4‐thiadiazine Derivatives.
Authors: Hui Xin‐Ping , Wang Qin , Zhang Qi , Zhang Zi‐Yi
Published: May 2010

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Synthesis of Novel C2‐Aryl Pyrrolobenzodiazepines (PBDs) as Potential Antitumor Agents.
Authors: Cooper Nectaroula , Hagan David R. , Tiberghien Arnaud , Ademefun Temitope , Matthews Charles S. , Howard Philip W. , Thurston David E.
Published: May 2010

For Abstract see ChemInform Abstract in Full Text.
Studies on Nitrogen‐ and Sulfur‐Containing Heterocycles. Part 55. Synthesis, Chemical, Spectral and Biological Properties of 3,12‐Diaza‐6,9‐diazoniadispiro[5,2,5,3]heptadecane Derivatives.
Authors: Safonova T. S. , Shatukhina E. A. , Sedov A. L. , Turchin K. F. , Sokolova A. S.
Published: May 2010

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Chelation‐Assisted Intramolecular Hydroacylation: Synthesis of Medium Ring Sulfur Heterocycles.
Authors: Bendorf Holly D. , Colella Christine M. , Dixon Elizabeth C. , Marchetti Melissa , Matukonis Alicia N. , Musselman Jeffrey D. , Tiley Tara A.
Published: May 2010

For Abstract see ChemInform Abstract in Full Text.
Efficient Atom Economic Approaches Towards Macrocyclic Crown Diamides via Ring‐Closing Methathesis.
Authors: Behbehani Haider , Ibrahim Maher R. , Ibrahim Yehia A.
Published: May 2010

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A New [5 + 2] Dipolar Cycloaddition in the Cycloimmonium‐Ylide Series.
Authors: Olariu Ivona , Caprosu Maria , Mangalagiu Ionel , Petrovanu Magda
Published: May 2010

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Efficient Highly Stereoselective Synthesis of Olefinic Macrocyclic Crown‐Formazans with the Z‐Configuration via Ring‐Closure Metathesis.
Authors: Ibrahim Yehia A. , Behbehani Haider , Ibrahim Maher R. , Abrar Nada M.
Published: May 2010

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Synthesis of Biologically Active 1‐Arylethylphosphonates.
Authors: Gulyukina N. S. , Dolgina T. M. , Bondarenko G. N. , Beletskaya I. P. , Bondarenko N. A. , Henry J.‐C. , Lavergne D. , Ratovelomanana‐Vidal V. , Genet J.‐P.
Published: May 2010

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Synthesis of New Optically Active Amino‐ and Alkoxy‐Tertiary Monophosphines.
Authors: Fagadar‐Cosma Eugenia , Fagadar‐Cosma Gheorghe , Taranu Ioan , Iliescu Smaranda , Grozav Mata
Published: May 2010

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Tandem Michael‐Aldol Reaction via 6‐endo‐Dig Cyclization of Ynone‐Chalcogenides: Synthesis of 2‐Unsubstituted 3‐(Hydroxyalkyl)chalcogenochromen‐4‐ones.
Authors: Kataoka Tadashi , Kinoshita Hironori , Kinoshita Sayaka , Iwamura Tatsunori
Published: May 2010

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Lunamarin C, a New Terpenoid Coumarin from Clausena heptaphylla
Authors: Sohrab Md. H. , Hasan C. M. , Rashid M. A.
Published: May 2010

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Merrillianin, a Unique seco‐Prezizaane‐Type Sesquiterpene, and (6R)‐Pseudomajucin from Illicium merrillianum.
Authors: Huang Jian‐Mei , Yang Chun‐Shu , Kondo Mamiko , Nakade Kosuke , Takahashi Hironobu , Takaoka Shigeru , Fukuyama Yoshiyasu
Published: May 2010

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Synthesis of 3‐O‐Acetylbetulinic and Betulonic Aldehydes by Swern Oxidation and Pharmacological Activity of Their Oximes.
Authors: Flekhter O. B. , Ashavina O. Yu. , Boreko E. I. , Karachurina L. T. , Pavlova N. I. , Kabal'nova N. N. , Savinova O. V. , Galin F. Z. , Nikolaeva S. N. , Zarudii F. S. , et al. et al.
Published: May 2010

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Identification of a Brassinosteroid, Castasterone from Marchantia polymorpha.
Authors: Kim Young‐Soo , Sup Yun Hye , Kim Tae‐Wuk , Joo Se‐Hwan , Kim Seong‐Ki
Published: May 2010

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New Polyoxygenated Steroids Exhibiting Reversal of Multidrug Resistance from the Gorgonian Isis hippuris
Authors: Tanaka Junichi , Trianto Agus , Musman Musri , Issa Hamad H. , Ohtani Ikuko I. , Ichiba Toshio , Higa Tatsuo , Yoshida Wesley Y. , Scheuer Paul J.
Published: May 2010

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Application of Cyano Ylide Methodology to the Synthesis of Cyclotheonamides E2 and E3.
Authors: Wasserman Harry H. , Zhang Rui
Published: May 2010

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N‐Chloroacyl Derivatives of Valine Esters
Authors: Knizhnikov V. A. , Potkin V. I. , Zhavnerko K. A. , Yakubovich L. S. , Petkevich S. K. , Kacherskaya S. P.
Published: May 2010

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Regioselective Benzoylation of Sugars Mediated by Excessive Bu2SnO: Observation of Temperature‐Promoted Migration.
Authors: Zhang Zhiyuan , Wong Chi‐Huey
Published: May 2010

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Stereoselective Synthesis of β‐D‐Mannopyranosides with Reactive Mannopyranosyl Donors Possessing a Neighboring Electron‐Withdrawing Group.
Authors: Abdel‐Rahman Adel A.‐H. , Jonke Simon , El Ashry El Sayed H. , Schmidt Richard R.
Published: May 2010

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Microwave‐Induced, Montmorillonite K10‐Catalyzed Ferrier Rearrangement of tri‐O‐Acetyl‐D‐galactal: Mild, Eco‐Friendly, Rapid Glycosidation with Allylic Rearrangement.
Authors: Shanmugasundaram Bhagavathy , Bose Ajay K. , Balasubramanian Kalpattu K.
Published: May 2010

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The First Total Synthesis of Goniothalesdiol.
Authors: Babjak Matej , Kapitan Peter , Gracza Tibor
Published: May 2010

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Applications of Vinylogous Mannich Reactions. Total Synthesis of the Angiotensin Converting Enzyme Inhibitor (‐)‐A58365A.
Authors: Reichelt Andreas , Bur Scott K. , Martin Stephen F.
Published: May 2010

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Novel Bioactive Isoquinoline Alkaloids from Carduus crispus.
Authors: Zhang Qingying , Tu Guangzhong , Zhao Yuying , Cheng Tieming
Published: May 2010

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A New and Efficient Synthesis of (‐)‐Indolizidine 167B by Tandem Metathesis.
Authors: Zaminer Jan , Stapper Christian , Blechert Siegfried
Published: May 2010

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Stereoselective Total Synthesis of (.+‐.)‐Homochelidonine.
Authors: Yoshida Makoto , Watanabe Toshiko , Ishikawa Tsutomu
Published: May 2010

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Stereoselective Conversion of Ethyl Pipecolinate into (.+‐.)‐α‐ and (.+‐.)‐β‐Conhydrins.
Authors: Lysenko I. L. , Bekish A. V. , Kulinkovich O. G.
Published: May 2010

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Reaction of Glycosyl Isothiocyanates with 3‐Indolylaminomethyl‐ketone Hydrochloride.
Authors: Saleh Mohamed A.
Published: May 2010

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Enantioselective Total Synthesis of (+)‐Isoaltholactone.
Authors: Peng Xiaoshui , Li Anpai , Lu Jiangping , Wang Qiaoling , Pan Xinfu , Chan Albert S. C.
Published: May 2010

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Exo‐ and Endohormones. Part 19. Synthesis of Z‐10‐Dodecen‐1‐yl Acetate. Component of Some Lepidopteran Insect Sex Pheromones.
Authors: Gansca Lucia , Oprean Ioan
Published: May 2010

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A Total Synthesis of Phomactin A.
Authors: Goldring William P. D. , Pattenden Gerald
Published: May 2010

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Synthesis of (‐)‐Galiellalactone.
Authors: Johansson Martin , Sterner Olov
Published: May 2010

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Cyclic Molecular Materials Based on [M2O2S2]2+ Cores (M: Mo or W)
Authors: Cadot Emmanuel , Secheresse Francis
Published: May 2010

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Structural Ceramics and Ceramic Composites for High Temperature Applications
Authors: several authors several authors
Published: May 2010

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Relativity, Gold, Closed‐Shell Interactions, and CsAu×NH3
Authors: Pyykkoe Pekka
Published: May 2010

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Lattice Distortion and Ferromagnetism in CaB6
Authors: Murakami Shuichi , Shindou Ryuichi , Nagaosa Naoto , Mishchenko Andrei S.
Published: May 2010

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Novel Synthesis of Electrode Materials for Li‐ion Batteries by the Emulsion Drying Method
Authors: Myung Seung‐Taek , Komaba Shinichi , Kumagai Naoaki , Chung Hoon‐Taek
Published: May 2010

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Power from the Structure Within: Application of Nanoarchitectures to Batteries and Fuel Cells
Authors: Carlin Richard T. , Swider‐Lyons Karen
Published: May 2010

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Confusion, Inversion, and Creation — A New Spring from Porphyrin Chemistry
Authors: Furuta Hiroyuki , Maeda Hiromitsu , Osuka Atsuhiro
Published: May 2010

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Synthesis of Oxathiacrown Compounds by the Reactions of Sulfur Dichloride with Unsaturated Compounds and Their Extraction Characteristics
Authors: Abramov A. A. , Anisimov A. V. , Bobyleva A. A.
Published: May 2010

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[Hydroxy(tosyloxy)iodo]benzene and Closely Related Iodanes: The Second Stage of Development
Authors: Koser Gerald F.
Published: May 2010

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Photoactive Layered Materials: Assembly of Ions, Molecules, Metal Complexes, and Proteins
Authors: Kumar Challa V. , Raju B. Bangar
Published: May 2010

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Recent Advances in Organic Reactions Catalyzed by Lanthanoid(III) Complexes
Authors: Chen Rui‐Fang , Qian Chang‐Tao
Published: May 2010

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Applications for Polyaza Macrocycles with Nitrogen‐Attached Pendant Arms
Authors: Wainwright Kevin P.
Published: May 2010

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Metal‐Mediated Discrete Supramolecular Assemblies of Porphyrins
Authors: Alessio Enzo , Iengo Elisabetta , Marzilli Luigi G.
Published: May 2010

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Evaluation of the Synthetic Product
Authors: Grant Gregory A.
Published: May 2010

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Peptide Design Considerations
Authors: Moore Michael L. , Grant Gregory A.
Published: May 2010

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Manual Peptide Synthesis
Authors: Petersen Gabriele
Published: May 2010

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Chemistry of Fmoc Peptide Synthesis on Membranes
Authors: Zander Norbert , Gausepohl Heinrich
Published: May 2010

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Radioiodination Techniques for Aromatic Amino Acids
Authors: Vahatalo J. , Kulvik M. , Savolainen S. , Karonen S.‐L.
Published: May 2010

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Chemical Cleavage of Proteins at Cysteinyl‐X Peptide Bonds
Authors: Smith Bryan John
Published: May 2010

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Melagatran and Ximelagatran: Anticoagulant Thrombin Inhibitor
Authors: Sorbera L. A. , Bayes M. , Castaner J. , Silvestre J.
Published: May 2010

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Aliskiren Fumarate
Authors: Mealy N. E. , Castaner J. , Castaner R. M. , Silvestre J.
Published: May 2010

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New Approaches Toward the Formation of Silicon—Carbon Bonds on Porous Silicon
Authors: Stewart Michael P. , Buriak Jillian M.
Published: May 2010

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New Trends in Organolanthanoid Hydride Chemistry
Authors: Barbier‐Baudry Denise , Dormond Alain
Published: May 2010

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A Race Against Tin
Authors: Parsons Andrew
Published: May 2010

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Carbon—Carbon Bond Formation via Surface Organometallic Chemistry
Authors: Coperet C. , Thivolle‐Cazat J. , Basset J. M.
Published: May 2010

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Design Strategies for Supramolecular Porphyrin‐Based Materials
Authors: Goldberg Israel
Published: May 2010

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Carbanions and Electrophilic Aliphatic Substitution
Authors: Knipe A. C.
Published: May 2010

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Electrophilic Aromatic Substitution
Authors: Coombes R. G.
Published: May 2010

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Nucleophilic Aromatic Substitution
Authors: Crampton M. R.
Published: May 2010

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Radical Reactions. Part 2.
Authors: Dobbs A. P. , Martin J. N.
Published: May 2010

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Radical Reactions. Part 1.
Authors: Clark A. J. , Filik R. P.
Published: May 2010

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Reactions of Carboxylic, Phosphoric and Sulfonic Acids and Their Derivatives
Authors: Spillane W. J.
Published: May 2010

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Novel SOFC Anodes for the Direct Electrochemical Oxidation of Hydrocarbons
Authors: Gorte R. J. , Kim H. , Vohs J. M.
Published: May 2010

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Amino Acid‐Based Surfactants: Enzymatic Synthesis, Properties and Potential Applications
Authors: Clapes Pere , Infante Maria Rosa
Published: May 2010

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Synthesis and Properties of Some Nitrogen‐Containing Derivatives of 1,3,5‐Triazine.
Authors: Mikhailichenko S. N. , Chesnyuk A. A. , Suslov V. I. , Shkrebets A. I. , Yukhonenko M. M. , Zaplishyi V. N.
Published: May 2010

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Synthesis and Complexing Ability of a C‐Pivot Type of Double‐Armed 15‐Crown‐5 Ethers Toward Alkali Metal Cations.
Authors: Nakatsuji Yohji , Muraoka Masahiro , Kajiya Hiroyuki , Zhang Wanbin , Kida Toshiyuki , Ikeda Isao
Published: May 2010

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Synthesis and Enantiomeric Selectivity of Chiral Crown Ethers.
Authors: Luk'yanenko N. G. , Lobach A. V. , Leus O. N. , Titova N. Yu.
Published: May 2010

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A Stoichiometric Aromatic C—H Borylation Catalyzed by Iridium(I)/2,2′‐Bipyridine Complexes at Room Temperature.
Authors: Ishiyama Tatsuo , Takagi Jun , Hartwig John F. , Miyaura Norio
Published: May 2010

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Nucleophilic Borylation of Benzyl Halides with Bis(pinacolato)diboron Catalyzed by Palladium(0) Complexes.
Authors: Ishiyama Tatsuo , Oohashi Zengo , Ahiko Taka‐aki , Miyaura Norio
Published: May 2010

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Silylstannation of Terminal Alkynes Using a Recyclable Palladium(0) Catalyst Immobilized in an Ionic Liquid.
Authors: Hemeon Ivan , Singer Robert D.
Published: May 2010

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Enantioselective Total Synthesis of (+)‐Testudinariol A Using a New Nickel‐Catalyzed Allenyl Aldehyde Cyclization.
Authors: Amarasinghe Kande K. D. , Montgomery John
Published: May 2010

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A General Method for the Highly Diastereoselective, Kinetically Controlled Alkylation of (+)‐Nopinone.
Authors: Campos Kevin R. , Lee Sandra , Journet Michel , Kowal Jason J. , Cai Dongwei , Larsen Robert D. , Reider Paul J.
Published: May 2010

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Towards a Total Synthesis of Guanacastepene A: Construction of Fully Functionalized AB and BC Ring Segments.
Authors: Mehta Goverdhan , Umarye Jayant D. , Gagliardini Vanessa
Published: May 2010

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Stereoselectivity in the Fe(II)/Cu(II)‐Mediated Homolytic Decomposition of the cis‐ and trans‐Isomers of Pinane Hydroperoxide.
Authors: Lempers H. E. B. , Sheldon R. A. , Swift K. A. D.
Published: May 2010

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3‐Pyrroline Containing Arylacetamides: A Novel Series of Remarkably Selective ϰ‐Agonists.
Authors: Mou Qi‐Yong , Chen Jie , Zhu You‐Cheng , Zhou De‐He , Chi Zhi‐Qiang , Long Ya‐Qiu
Published: May 2010

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N‐Cycloalkanoyl‐L‐Phenylalanine Derivatives as VCAM/VLA‐4 Antagonists.
Authors: Tilley Jefferson W. , et al. et al.
Published: May 2010

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Use of Phenyl 2‐α‐Selenoglycosides of N‐Acetylneuraminic Acid as a Glycosyl Donor for the Glycosylation Reactions.
Authors: Ikeda Kiyoshi , Sugiyama Yuji , Tanaka Kiyoshi , Sato Masayuki
Published: May 2010

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Vinyl Fluoride as an Isoelectronic Replacement for an Enolate Anion: Inhibition of Type II Dehydroquinases.
Authors: Frederickson Martyn , Coggins John R. , Abell Chris
Published: May 2010

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Novel 20‐Carbonate Linked Prodrugs of Camptothecin and 9‐Aminocamptothecin Designed for Activation by Tumor‐Associated Plasmin
Authors: de Groot Franciscus M. H. , Busscher Guuske F. , Aben Rene W. M. , Scheeren Hans W.
Published: May 2010

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Synthesis and Biological Evaluation of Novel D‐2′‐Azido‐2′,3′‐dideoxyarabinofuranosyl‐4′‐thiopyrimidines and Purines.
Authors: Kim Hea Ok , Park Yong Hee , Moon Hyung Ryong , Jeong Lak Shin
Published: May 2010

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Synthesis and SAR of Azalide 3,6‐Ketal Aromatic Derivatives as Potent Gram‐Positive and Gram‐Negative Antibacterial Agents.
Authors: Cheng Hengmiao , et al. et al.
Published: May 2010

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Preparation of Chiral 4‐Benzyloxymethyldihydrofuran‐2‐one Using Lipase‐Catalyzed Kinetic Resolution: Synthesis of (‐)‐Virginiae Butanolide C (VB C).
Authors: Takabe Kunihiko , Mase Nobuyuki , Matsumura Hidetoshi , Hasegawa Takehiro , Iida Yasuhiro , Kuribayashi Hisashi , Adachi Kenji , Yoda Hidemi , Ao Masato
Published: May 2010

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Synthesis of 4‐Acetylisocoumarin: First Total Syntheses of AGI‐7 and Sescandelin.
Authors: Kim Sanghee , Fan Gao‐jun , Lee Jaekwang , Lee Jung Joon , Kim Deukjoon
Published: May 2010

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1‐(Bicyclopiperazinyl)ethylindoles and 1‐(Homopiperazinyl)ethylindoles as Highly Selective and Potent 5‐HT7 Receptor Ligands.
Authors: Issac Methvin B. , Xin Tao , O'Brien Anne , St‐Martin David , Naismith Angela , MacLean Neil , Wilson Julie , Demchyshyn Lidia , Tehim Ashok , Slassi Abdelmalik
Published: May 2010

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Epitaxial Stabilization of Oxides in Thin Films
Authors: Gorbenko O. Yu. , Samoilenkov S. V. , Graboy I. E. , Kaul A. R.
Published: May 2010

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Intercalation Compounds of Graphite
Authors: Dresselhaus M. S. , Dresselhaus G.
Published: May 2010

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Itinerant Metamagnetism of CeRu2Si2: Bringing Out the Dead. Comparison with the New Sr3Ru2O7 Case
Authors: Flouquet J. , Haen P. , Raymond S. , Aoki D. , Knebel G.
Published: May 2010

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Molecular Phosphates and Phosphonates of Aluminum and Gallium: Potential Applications in Materials Synthesis
Authors: Mason Mark R. , Matthews R. Mark , Perkins Alisa M. , Ponomarova Vira V.
Published: May 2010

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Polyfunctional Indium Lewis Acids with o‐Phenylene Backbones
Authors: Gabbai Francois P.
Published: May 2010

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New Synthetic Tactics Designed to Access Diynes and Polyynes
Authors: Hartung Ryan , Paquette Leo
Published: May 2010

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The First Intermolecular Transition Metal Catalyzed [5 + 2] Cycloadditions with Simple, Unactivated Vinylcyclopropanes
Authors: Fairweather N. T. , Curran D. P.
Published: May 2010

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Syntheses of L‐Iduronyl Synthons
Authors: Pellissier Helene
Published: May 2010

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Recent Progress in the Asymmetric Synthesis of α‐Substituted Propargylamines
Authors: Blanchet J. , Bonin M. , Micouin L.
Published: May 2010

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New Efficient Iterative Approaches to Polycyclic Ethers
Authors: Marmsaeter Fredrik P. , West Frederick G.
Published: May 2010

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Drug Design Strategies for Targeting G‐Protein‐Coupled Receptors
Authors: Klabunde Thomas , Hessler Gerhard
Published: May 2010

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Applications of Novel Sterically Demanding Aromatics in Organometallic Synthesis
Authors: Steele Bary R. , Micha‐Screttas Maria , Screttas Constantinos G.
Published: May 2010

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Catalytic C—H/Olefin Coupling.
Authors: Kakiuchi Fumitoshi , Murai Shinji
Published: May 2010

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Design and Implementation of New, Silicon‐Based, Cross‐Coupling Reactions: Importance of Silicon—Oxygen Bonds.
Authors: Denmark Scott E. , Sweis Ramzi F.
Published: May 2010

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Thermal Reactions of Dipolar Trimethylenemethane Species.
Authors: Nakamura Eiichi , Yamago Shigeru
Published: May 2010

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Evolution of the Vinylogous Mannich Reaction as a Key Construction for Alkaloid Synthesis.
Authors: Martin Stephen F.
Published: May 2010

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Synthetic and Mechanistic Studies of the Cycloisomerization and Cyclization/Hydrosilylation of Functionalized Dienes Catalyzed by Cationic Palladium(II) Complexes.
Authors: Widenhoefer Ross A.
Published: May 2010

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Developing Green Chemistry: Organometallic Reactions in Aqueous Media
Authors: Chan Tak Hang , Li Lianhai , Yang Yang , Lu Wenshuo
Published: May 2010

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Lewis Acid Catalysis in Clean Solvents, Water, and Supercritical Carbon Dioxide
Authors: Kobayashi Shu , Manabe Kei
Published: May 2010

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Catalysis Using Supercritical or Subcritical Inert Gases under Split‐Phase Conditions
Authors: Jessop Philip G. , Eckert Charles A. , Liotta Charles L. , Bonilla R. Jason , Brown James S. , Brown Richard A. , Pollet Pamela , Thomas Colin A. , Wheeler Christy , Wynne Dolores
Published: May 2010

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Charge‐Transfer Excited States of Transition Metal Complexes
Authors: Endicott John F.
Published: May 2010

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Electron Interactions with Cyclo‐C4F8
Authors: Christophorou Loucas G. , Olthoff James K.
Published: May 2010

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Biomimetic Electron‐Transfer Chemistry of Porphyrins and Metalloporphyrins
Authors: Fukuzumi Shunichi , Imahori Hiroshi
Published: May 2010

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Electron‐Correlated Approaches for the Calculation of NMR Chemical Shifts
Authors: Gauss Jurgen , Stanton John F.
Published: May 2010

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Mass Spectrometry of β‐Lactam Antibiotics
Authors: Gioacchini Anna M. , Traldi Pietro
Published: May 2010

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Adjusting transgene expression levels in lymphocytes with a set of inducible promoters
Authors: Danke Christina , Grünz Xandra , Wittmann Jürgen , Schmidt Andreas , Agha‐Mohammadi Siamak , Kutsch Olaf , Jäck Hans‐Martin , Hillen Wolfgang , Berens Christian
Published: May 2010

Background

Inducible gene expression systems are powerful research tools and could be of clinical value in the future, with lymphocytes being likely prime application targets. However, currently available regulatable promoters exhibit variation in their efficiency in a cell line‐dependent‐manner and are notorious for basal leakiness or poor inducibility. Data concerning the regulatory properties of different inducible promoters are scarce for lymphocytes. In the present study, we report a comprehensive analysis of how various inducible promoters perform and how their combination with a transsilencer and a reverse transactivator can result in optimally controlled gene expression in T‐cells.

Methods

The performance of the tetracycline‐regulated (Tet)‐inducible promoters Tet‐responsive element (TRE), mouse mammary tumor virus (MMTV)/TRE, TREtight and second generation TRE (SG/TRE) was compared in several B‐cell lines and in Jurkat T‐cells using transient transfections in combination with Tet‐On. To monitor transgene expression in a Jurkat cell line containing a transsilencer and a reverse transactivator, expression cassettes encoding enhanced green fluorescent protein, CD123 or a constitutively active, cytotoxic caspase‐3 were flanked with insulators and stably integrated. The performance of TREtight and SG/TRE was furthermore analysed in transiently transfected primary CD4+ human T‐cells.

Results

The promoters exhibit greatly diverging characteristics. MMTV/TRE permits moderate, TRE and TREtight permits intermediate and SG/TRE permits very high expression levels. TRE and SG/TRE are leaky, whereas MMTV/TRE and TREtight provide stringent expression control. Tetracycline derivatives add flexibility to transgene expression by introducing intermediate expression levels.

Conclusions

The different expression profiles of the promoters increase the flexibility to adjust transgene expression levels. The promoters provide an additional option to optimize system performance for many applications. Copyright © 2010 John Wiley & Sons, Ltd.
REST corepressor (CoREST) repression induces phenotypic gene regulation in advanced osteoarthritic chondrocytes
Authors: Xiao Jun , Li Tao , Wu Zhihong , Shi Zhanjun , Chen Jianting , Lam Stephen K.L. , Zhao Zandong , Yang Lanbo , Qiu Guixing
Published: May 2010

Alternations in cartilage chondrocyte phenotype characteristic by the decreased type II collagen and aggrecan together with increased type X collagen synthesis serve as a beacon for osteoarthritis progression. However, little is known about the underlying molecular mechanisms. The current study seeks to discover molecules that involved in osteoarthritic chondrocytes phenotype regulation. Differential proteomics was generated with two‐dimensional gel electrophoresis between normal articular cartilage (NAC) and advanced osteoarthritic cartilage (AOC). Those differentially expressed proteins were identified by mass spectrometry. The down‐regulation of a neuronal silencer, the REST corepressor (CoREST) in AOC, was verified by Western blot. CoREST silencing was performed in primarily cultured NAC chondrocytes with specific siRNA to reveal the possible involvement of CoREST repression in chondrocyte phenotypic genes modulation. Ninteen differentially expressed proteins were screened and identified. Among these proteins, CoREST, HHL, and zinc finger protein 155 were estimated to be possible gene modulators. CoREST protein level was verified to be down‐regulated by 69.5% (p < 0.001) in AOC. In response to CoREST knock‐down by 64.8% (p < 0.001) in NAC chondrocytes, the gene expression level of the chondrocyte terminal differentiation marker gene, collagen X was found to be up‐regulated by 40.0% (p = 0.017), whereas the chondrocyte differentiation phenotypic genes, collagen II and aggrecan were down‐regulated by 71.4% (p < 0.001) and 57.6% (p < 0.001), respectively. The results indicate that the silencing of CoREST by siRNA transfection in NAC may reflect CoREST repression in AOC, which results in phenotypic genes modulation and suggests a homeostatic role of this transcription factor in articular chondrocyte. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1569–1575, 2010
The quadriga effect revisited: Designing a “safety incision” to prevent tendon repair rupture and gap formation in a canine model in vitro
Authors: Giambini Hugo , Ikeda Jun , Amadio Peter C. , An Kai‐Nan , Zhao Chunfeng
Published: May 2010

Loss of experimental animals due to tendon repair failure results in the need for additional animals to complete the study. We designed a relief proximal to the flexor digitorum profundus (FDP) tendon repair site to serve as a “safety incision” to prevent repair site ruptures and maximize safety incision‐to‐suture strength. The FDP tendons were dissected in 24 canine forepaws. The 2nd and 5th tendons were lacerated at the proximal interphalangeal joint level and sutured using a modified Kessler technique and peripheral running suture. Tendon width was measured where the FDP tendon separates into each individual digit and a safety incision, equal to the 2nd and 5th tendon widths, was performed 3, 4, or 5 mm (Groups 1, 2, and 3) proximal to the separation. The tendons were pulled at a rate of 1 mm/s until either the “safety incision” ruptured or the repair failed. There was no gap formation at the repair site in Groups 1 and 2. However, all Group 3 tendons failed by repair site rupture with the safety incision intact. An adequate safety incision to protect repair gap and rupture and maintain tendon tension for the FDP animal model should be about 4 mm from where the FDP tendon separates. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1482–1489, 2010
Compact monopole antenna with branch strips for WLAN/WiMAX operation
Authors: Ku Chia‐Hao , Li Lung‐Kun , Mao Wei‐Lung
Published: May 2010

This study proposes a novel and compact design for a printed monopole antenna using branch strips for wireless applications.The antenna consists of three strips and occupies only a small area of 14 × 9.5 mm2. By proper selection of dimensions as well as arrangement of the strips, desired resonant modes excited at 2.46/3.6/5.3 GHz with frequency responses of input impedance of less than −10 dB can be achieved. In addition, good agreement is obtained between the simulation and the experiment. Also, the compact design of the antenna, which has enough impedance bandwidth, near‐omnidirectional patterns and moderate gains, makes the antenna suitable for wireless local area network and worldwide interoperability for microwave access operations. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1858–1861, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25293
Dual band electromagnetic band gap resonator antenna to feed a reflector antenna
Authors: Kanso A. , Chantalat R. , Thevenot M. , Monediere T. , Arnaud E. , Jecko B.
Published: May 2010

This article describes a dual band electromagnetic band gap antenna that is suitable to feed a reflector antenna for space applications. The main objectives consist in the same phase center and the same radiations patterns for the two fréquency bands. The principle, the design, and the performances are given in this article. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1750–1756, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25294
Integrated wide‐narrow band antenna for switched operation
Authors: Kelly James R. , Hall Peter S.
Published: May 2010

Cognitive Radio (CR) is a new paradigm which promises to yield an improved quality of service for the user, whilst also enabling more intensive use of the available radio frequency spectrum. Some experts believe that CR will require both wide and narrowband antennas for performing the search and communication function. This article helps to address this need by providing a new antenna that can be reconfigured between a narrow and ultrawide impedance bandwidth. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1705–1707, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25298
A novel folded slot antenna for UWB applications
Authors: Chiu Chien‐Wen , Li Chia‐Shan , Yang Chih‐Hsiang
Published: May 2010

This letter presents a compact and novel folded antenna with curved slots for ultra‐wideband (UWB) applications.The proposed antenna originates from an antenna, which consists of a pair of symmetrically curved radiating slots fed by a CPW transmission line. This pair of planar curved slots is symmetrically folded in relation to the central feeding lines so that the size is shrunk to one half of the original geometric size. Using the HFSS software, the simulated results shows that the folded type antenna still preserves the UWB transmission characteristics. The impedance bandwidth, radiation pattern, and radiation gains of this shrunken UWB antenna are investigated and further measurement are performed to verify its UWB characteristics. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1872–1877, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25299
Analysis and design of class‐E power amplifier using equivalent LDMOS model with drift region effect
Authors: Xu Yingjie , Zhu Xiaowei , You Changjiang
Published: May 2010

In this article, an LDMOS class‐E power amplifier is analyzed based on the equivalent transistor model considering drift region effect.In the analysis, nonzero switch‐on resistance, parasitic feedback capacitance, and finite drain DC feed inductance are taken into account, so as to present an optimized design technique. A class‐E power amplifier at 1 GHz is designed and simulated using the numerical results derived from the theoretical analysis. Freescale's MRF21010 is selected as the LDMOS device to further validate the design approach in experiment. Testing results show that drain efficiency of 70.4%, PAE of 66.2%, and output power of 38.28 dBm are observed with a 12 V drain supply voltage and a 26 dBm input power, which agrees with simulation data. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1836–1842, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25301
Development of an active retrodirective antenna with frequency conversion
Authors: Flores‐Leal R. , Jardon‐Aguilar H. , Tirado‐Mendez A.
Published: May 2010

The development of an active retrodirective antenna involving frequency conversion stages is presented.This retrodirective array of printed dipoles and regular commercial components is designed to operate at the GSM1900 band. Experimental measurements of monoestatic and biestatic responses are given, showing very good performance for a small retrodirective array. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1803–1807, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25303
Low‐profile radio frequency identification tag antenna using a trapezoid patch mountable on metallic surfaces
Authors: Chen Horng‐Dean , Tsao Yu‐Hung , Kuo Che‐Yang
Published: May 2010

A trapezoid patch antenna, designed for ultra high frequency band radio frequency identification tag mountable on metallic surfaces, is presented in this article. The proposed antenna has a simple and low‐profile (0.8 mm thick) structure. The impedance matching can be easily achieved by adjusting the upper‐side width and the height of the trapezoid patch. The reading range of the proposed antenna is verified by calculation and measurement, which shows good agreement. Varying antenna size can provide applicable reading range to suit different applications. The results obtained show that the proposed antenna can work efficiently in free space and on metallic objects. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1697–1700, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25310
Design for a linear voltage‐controlled 360°‐analog phase shifter
Authors: Xiao M. X. , Cheung S. W. , Yuk T. I.
Published: May 2010

The article presents the design of a linear voltage‐controlled 360° analog phase shifter operating at 2.2 GHz. It is a reflection‐type with a simple and compact structure, using a λ/4‐coupled‐line coupler with the output ports terminated with identical parallel‐tuned varactor‐diode circuits for a full 360°‐phase shift. Formulas are derived for making use of the dimensions of the transmission lines to linearize the phase shift against the control voltage. Simulation and measurement results on the linearity and insertion loss are presented. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1821–1825, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25314
Dynamic modulated Gaussian pulse propagation within the double PANDA ring resonator system
Authors: Uomwech K. , Sarapat K. , Yupapin P. P.
Published: May 2010

We propose the interesting results of light pulse propagation within a double PANDA ring resonator system.We use the technique of finite difference time domain that is implemented by the scientific programming method known as OPTI‐WAVE PROGRAMMING to simulate and analyze the dynamic wave forms of propagating light pulse within the desired system. By using the input Gaussian pulse with center wavelength at 1550 nm and the other practical parameters into the system, results obtained have shown that the multiwavelength light sources can be generated and achieved, and the dynamic behaviors of light pulses propagating within the system can be seen. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1818–1821, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25315
A novel CMOS distributed receiver front‐end for wireless ultrawideband receivers
Authors: Guan Xin , Nguyen Cam
Published: May 2010

An ultrawideband CMOS distributed receiver front‐end utilizing cascade gain cell structure is designed in Jazz 0.18‐μm CMOS process.The proposed distributed front‐end, fully integrating a low‐noise amplifier (LNA) and mixer together, demonstrates 11.5–14 dB gain, 5–6.5 dB noise figure and more than 9‐dB RF/LO return loss over 2–17 GHz with a fixed IF frequency of 500 MHz and LO power of 5 dBm. The entire circuit occupies 1.7 × 1.0 mm2 including on‐wafer pads and consumes 170 mA from 1.8‐V voltage supply. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1790–1792, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25316
Performances of MR‐preconditioned fast MoM techniques
Authors: De Vita P. , De Vita F. , Freni A. , Pirinoli P. , Vipiana F. , Vecchi G.
Published: May 2010

In this article, we describe the integration of a multiresolution (MR) approach into a few fast factorization methods for the method‐of‐moments (MoM), with specific attention to the analysis of large nonperiodic arrays. The MR approach allows a physics‐based preconditioning scheme (as opposed to algebraic preconditioners) that requires a low‐memory occupation and a low‐computational cost for its generation and application to fast factorizations. In particular, we present a theoretical and experimental analysis that shows that the complexity of the resulting fast‐MR algorithm is still of the order of the original fast factorization method. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1719–1724, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25320
Dual ISM‐band gap‐filler microstrip antenna with two Y‐shaped slots for satellite internet service
Authors: Kim Byoungchul , Ryu Joongyu , Choo Hosung , Lee Hojin , Park Ikmo
Published: May 2010

This article describes a dual‐band gap‐filler microstrip antenna with nearly equal gain and similar radiation patterns in the 2.4‐GHz and 5.8‐ GHz ISM satellite Internet service bands.The proposed antenna has two Y‐shaped slots on the microstrip patch and is fabricated on an RO4003 substrate with a dielectric constant of 3.38 and a thickness of 0.508 mm. The dimensions of the antenna are 50 mm × 47.5 mm × 6.5 mm, and it is fed by a coaxial cable. The measured bandwidths of the antenna are 2.376–2.492 GHz and 5.425–6.055 GHz for a voltage standing wave ratio of less than 2. At 2.42 GHz, the antenna has a broadside radiation pattern with a half‐power beamwidth (HPBW) of 70° in the x‐z plane and 80° in the y‐z plane. At 5.75 GHz, it has a HPBW of 65° in the x‐z plane and 75° in the y‐z plane. The measured gain is 8.37 dB in the 2.4‐GHz ISM band and 8.38 dB in the 5.8 GHz ISM band. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1825–1827, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25325
Composite right/left handed transmission line based on open slot split ring resonator
Authors: Karthikeyan S. S. , Kshetrimayum R.S.
Published: May 2010

In this article, an open slot split ring resonator (OSSRR) is introduced to realize a composite right/left handed (CRLH) transmission line structure in microstrip technology.The CRLH line is synthesized by etching OSSRR in the ground plane and interdigital capacitor in the microstrip line. Simulated and measured scattering parameter of the structure is presented. The dispersion characteristic of proposed structure is also shown. The proposed structure is 15% smaller than the conventional complementary split ring resonator structure. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1729–1731, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25330
Wideband spurious suppression of dual‐mode band‐pass filter using defected cascaded resonators
Authors: Wu Hung‐Wei , Weng Min‐Hang , Hung Cheng‐Yuan , Yang Ru‐Yuan
Published: May 2010

This article presents a new design of wideband spurious suppression of dual‐mode band‐pass filter (BPF) using defected cascaded resonators (DCRs).The pattern of the DCRs is similar with that of the conventional low‐pass stepped impedance resonator, whereas it is etched in the ground. It is verified that adding DCRs in planar BPF can effectively provide a very wideband range for spurious suppression. The dual‐mode BPF is designed at center frequency (f0) of 5.2 GHz, and has a very wideband spurious suppression below 30 dB as far as over 5f0 when using the DCRs. The measured results have a good agreement with the EM simulated results. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1694–1697, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25332
Optimization of output matching network for class F power amplifier according to envelope in the envelope elimination and restoration transmitter
Authors: Lee Chongmin , Seo Chulhun
Published: May 2010

This article presents the design and optimization of output matching network according to envelope for class F power amplifier (PA), which is to apply to envelope elimination and restoration (EER) transmitter.In this article, to increase the PAE of class F PA, which applies to EER transmitter, the varactor diode has been used on output matching network. As envelope changes, it optimizes constitution of harmonic trap that is short circuit in second‐harmonic and is open circuit in third‐harmonic. When drain voltage changes from 25 V to 30 V, some percentage is improved in the PAE. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1890–1893, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25335
A 3‐bit phase shifter with high‐power capacity based on composite right/left‐handed transmission line
Authors: Zhang J. , Cheung S.W. , Yuk T. I.
Published: May 2010

A miniaturized 3‐bit phase shifter with high power‐handling capacity is designed based on the use of a single composite right/left‐handed transmission line (CRLH‐TL) unit cell. PIN diodes mounted on the fingers of the CRLH‐TL unit cell are used as switches to control the phase shift of the input signal. Different phase shifts are achieved by using different states of the switches determined by the 3 controlling bits of the phase shifter. The surface current flowing through each of the switches is only a fraction of the total current through the device, so the power handled by each of the PIN diodes is much smaller than the total power through the device. The phase shifter is designed to provide a phase‐shift range from 0° to 157.5° at a step 22.5° and operate in the frequency band from 9 to 10 GHz. Simulation results and measurement results of the prototype agree closely and show that the phase shifter has much higher power‐handling capacities than that of the PIN diode and low insertion losses across the operating frequency band. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1778–1782, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25346
A dual continuous‐ and burst‐mode clock recovery module utilizing fiber dispersion
Authors: Yan Minhui , Chen Chih‐Hung , Xu Qing‐Yang , Huang Wei‐Ping
Published: May 2010

A clock recovery module suitable for both burst‐ and continuous‐mode optical receiver utilizing fiber dispersion is experimentally demonstrated for the first time. The module utilizes the nonlinear characteristics of the received nonreturn‐to‐zero (NRZ) optical signals experiencing the fiber dispersion and the photo‐detection to extract the clock information. Experiments demonstrated its functionality in both operation modes up to 9 Gbps. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1747–1750, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25347
Gain factor of horn array feed offset parabolic cylindrical reflector antenna for spatial power combining
Authors: Xie Z. M. , Zhang R.X.
Published: May 2010

A study on the horn array feeding offset parabolic cylindrical reflector antenna for spatial power combining is presented. The calculations based on the aperture integral method are agreed well with the measurements. The relationship between the gain factor and the dimensions of the antenna is analyzed. The optimal dimensions and orientation of the feeding horn as well as the optimal spread angle of the reflector are given. It is revealed that the gain factor of the antenna with anE_plane array feed is higher than that of the antenna with anH_plane array feed. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1742–1747, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25348
A novel band rejection filter of transmission line type using double spur‐lines
Authors: Eom Soon‐Young , Hong Ic‐Pyo
Published: May 2010

This letter presents a novel band rejection filter (BRF) using a pair of spur‐lines or double spur‐lines with an opposite direction, which is embedded in a transmission line. The slot length (L1) of double spur‐lines determines a rejection band and the distance (L2) between the end points of each spur‐line determines the position of a pass band, which is at the left or right side of a rejection band, respectively. That is, if L2 is shorter than L1, the right side of a pass band can be properly suppressed, otherwise if L2 is longer than L1, the left side of a pass band can be suppressed. Two novel kinds of BRFs were realized at Ku‐band using soft Teflon substrate to verify the validity of the proposed structure. The measured performance was well agreed with the simulated one. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1880–1883, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25351