bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS MARKETING SYARIAH TERHADAP STRATEGI PEMASARAN KERIPIK TEMPE DE YATI MADIUN
Authors: Rizki Utami  , Unun Roudlotul Janah
Published: January 2023

This study will discuss the effect of financial performance on stock returns of mining companies that go public on the Indonesian stock exchange. This study uses secondary data. The population in this study are mining companies listed on the Indonesia Stock Exchange, and the year of the study was from 2013 to 2015. In this study, 3 independent variables with 2 control variables and one dependent variable were used. The data analysis used is Descriptive Statistics, Classical Assumption Test, and Multiple Linear Regression. While the hypothesis testing used in this study using the Feasibility Test Model (F) and Hypothesis Testing (t). The results showed that Earning Per Share (EPS) and Price Book Value (PBV) had a positive effect on stock returns. While the Debt to Equity Ratio (DER) has a negative effect on stock returns in mining companies listed on the Indonesia Stock Exchange.

Abstrak

Penelitian ini akan membahas pengaruh kinerja keuangan terhadap return saham perusahaan pertambangan go public di bursa efek indonesia. Penelitian ini menggunakan data sekunder dengan Populasi dalam penelitian ini yaitu perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia, dan tahun penelitian nya adalah pada 2013 sampai tahun 2015. Dalam penelitian ini menggunakan 3 variabel independen dengan 2 variabel kontrol dan satu variabel dependen. Analisis data yang digunakan adalah Statistik Deskriptif, Uji Asumsi Klasik, dan Regresi Linear Berganda. Sedangkan Pengujian hipotesis yang digunakan dalam penelitian ini menggunakan Uji Kelayakan Model (F) dan Uji Hipotesis (t). Hasil penelitian menunjukkan bahwa Earning Per Share (EPS) dan Price Book Value (PBV) pengaruh positif terhadap return saham. Sedangkan Debt to Equity Ratio (DER) berpengaruh negatif terhadap return saham pada perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia.
Peran Orang Tua Dalam Membangun Financial Education Pada Anak Usia Dini
Authors: Irbah Ariq Nurjannah , Munastiwi Erni , Riyadi Ahmad Syafi’i Mufadzilah , Binsa Ucik Hidayah
Published: January 2023

Financial education needs to be done by parents because parents are an important role in family education. This study aims to determine how the role of parents in conducting financial education in early childhood. The method in this study uses a qualitative approach with four respondents who are domiciled in Magetan, East Java. The results showed that the role of parents in conducting financial education includes 1) parents are able to teach and set an example for children to save from an early age through the introduction of banks, 2) parents are able to provide creative education about finance through saving in a piggy bank that is made as creative as possible or provide an attractive piggy bank according to the child's character, 3) provide motivation for children to save money. The solution is to divert the child's attention, the father's role as a mediator, and communicate what is being taught.
A Systematic Review of Clinical Epidemiology and Outcomes of Emergency Department-Acute Kidney Injury Found High Incidence and Poor Outcomes
Authors: Cheung Tsz Yan , Lam Kelvin , Leung Siu Chung , Rainer Timothy H
Published: January 2023

Background: Over half of all community-acquired acute kidney injury (CA-AKI) initially presented to the emergency department (ED), but ED-AKI is poorly characterised, poorly understood, often under-recognised and under-managed. There is no systematic review focusing on ED-AKI. Yet, in-hospital AKI deaths are often associated with suboptimal recognition, management, and documentation.
Therefore, we aim to systematically review the incidence, risk factors, and outcomes of emergency department acute kidney injury (ED-AKI), and risk factors of post-ED-AKI mortality globally.
Methods: We included published prospective or retrospective observational studies, controlled trials, and systematic reviews reporting AKI in adult ED attendees within 24 hours of ED admission. Iatrogenic causes of AKI from medical interventions were excluded. We used PubMed to identify articles from 1996 to 14 August 2021, and adopted the National Heart, Lung, and Blood Institute (NHLBI) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies to assess risk of bias. We used a forest plot to present the pooled ED-AKI incidence rates and I2 statistics. Other parameters were summarised narratively in a tabular form.
Results: We identified six articles using 24 hours from ED admission as the definition for ED-AKI from 2005 to 2018 in high-income settings and one article with a 48-hour timeframe. The pooled incidence of ED-AKI was 20 per 1000 adult ED attendances. Risk factors for ED-AKI included increasing age, nursing home residence, previous hospital admission within 30 days, discharge diagnosis of diabetes, obstructive uropathy, sepsis, gastrointestinal medical conditions, high serum creatinine, bilirubin, C-reactive protein, white blood cell, alanine aminotransferase, low serum sodium or albumin on admission, poor premorbid renal function, antibiotic use, active malignancy, lung disease, hyperlipidaemia, and infection. The crude, all-cause 24-hour mortality rate was 4.56% and one-year mortality was 35.04%. Increasing age and comorbidities including cardiovascular disease and malignancy were associated with higher mortality rates.
Conclusion: The review reveals high burden of ED-AKI. Compared to general AKI, ED-AKI has higher mortality rate and different risk factors. Main limitations include limited articles, heterogeneity of incidences, and no confounder adjustment. This calls for further research, red flag identification, and standardized management protocols for ED-AKI.
Predictive Models and Features of Patient Mortality across Dementia Types
Authors: Zhang Jimmy , Song Luo , Chan Kwun , Miller Zachary , Huang Kuan-lin
Published: January 2023

Dementia care is challenging due to the divergent trajectories in disease progression and outcomes. Predictive models are needed to identify patients at risk of near-term mortality. Here, we developed machine learning models predicting survival using a dataset of 45,275 unique participants and 163,782 visit records from the U.S. National Alzheimer’s Coordinating Center (NACC). Our models achieved an AUC-ROC of over 0.82 utilizing nine parsimonious features for all one-, three-, five-, and ten-year thresholds. The trained models mainly consisted of dementia-related predictors such as specific neuropsychological tests and were minimally affected by other age-related causes of death, e.g., stroke and cardiovascular conditions. Notably, stratified analyses revealed shared and distinct predictors of mortality across eight dementia types. Unsupervised clustering of mortality predictors grouped vascular dementia with depression and Lewy body dementia with frontotemporal lobar dementia. This study demonstrates the feasibility of flagging dementia patients at risk of mortality for personalized clinical management.
A 48-node All-to-all Connected Coupled Ring Oscillator Ising Solver Chip
Authors: Lo Hao , Moy William , Yu Hanzhao , Sapatnekar Sachin , Kim Chris H.
Published: January 2023

This paper presents a physics-based Ising solver chip fabricated in a standard 1.2V, 65 nanometer complementary metal oxide semiconductor (CMOS) technology featuring an all-to-all architecture with 48 spins and a highly-uniform coupling circuit with integer weights ranging from -14 to +14. Existing locally-connected architectures suffer from size and digital computation overheads while embedding an arbitrary graph. In contrast, our all-to-all connected design allows any graph with up to 48 nodes to be directly mapped to the hardware. The key idea of the all-to-all architecture is to strongly couple a horizontal oscillator with a vertical oscillator so that each horizontal-vertical oscillator pair intersects with all other pairs in the cross-bar style array. The multi-bit coupling circuit was realized by cascading 1-bit coupler stages comprising a pair of inverters and two transmission gates. Statistical measurements were carried out on the fabricated Ising solver chips for different problem sizes, graph densities, operating temperatures, problem instances, and solution samples. The measured oscillation period, power consumption, and relaxation time for different problems are also reported. Finally, we show that dynamically merged spins can achieve higher weight resolution without hardware changes.
Association of Polycyclic Aromatic Hydrocarbon Metabolite Concentration in Urine and Occupational Stress in Underground Coal Miners, China
Authors: Zhang Hongmei , Cao Jingjing , Liu Aixiang , Gao Qian , Nie Jisheng , Zhou Xiaoling , Huang Jianjun , Sun Chenming , Wang Tong
Published: January 2023

This study intends to examine the association of urinary PAHs metabolite concentration and occupational stress in coal miners. We sampled 671 underground coal miners from Datong, China, assessed their occupational stress using the Occupational Stress Inventory-Revised edition (OSI-R), and categorized them into the high stress group and controls based on the occupational stress assessment. We determined urinary hydroxyl PAHs (OH-PAHs) concentrations using the ultrahigh performance liquid chromatography-tandem mass spectrometry, and analyzed the association of OH-PAHs concentration with occupational stress using multiple linear regression and covariate balancing generalized propensity score. The low molecular weight (LMW) OH-PAHs and its quartiles were positively associated with Occupational Role Questionnaire (ORQ) score. The OH-PAHs concentration was not associated with PSQ or PRQ score. The OH-PAHs concentration in urine was positively associated with ORQ score in coal miners, particularly the LMW OH-PAHs. Non-association was found in the OH-PAHs concentration with PSQ or PRQ scores.
Cross-talk between carbon monoxide and hydrogen sulfide on the CBS expression and neurotoxicity induced by Chronic Kidney Disease in the male rats
Authors: Hamidizad Zeinab , Kadkhodaee Mehri , Kianian Farzaneh , Ranjbaran Mina , Seifi Behjat
Published: January 2023

Neurotoxicity is implicated as a severe complication of chronic kidney disease (CKD). Accumulation of urea and other toxic compounds leads to oxidative stress, inflammation, and destruction of the blood-brain barrier. Carbon monoxide (CO) and hydrogen sulfide (H2S) have been shown to have anti-inflammatory, anti-apoptotic, and anti-proliferative properties. The present study aimed to evaluate the protective effects of CO-releasing molecule (CORM3) and H2S donor (NaHS) on oxidative stress and neuronal death induced by CKD in the hippocampus and prefrontal cortex by considering theinteraction between CO and H2S on CBS expression. CORM3 or NaHS significantly compensated deficits in the antioxidant defense mechanisms, suppressed lipid peroxidationand reduced neuronal death in the hippocampus and prefrontal cortex and, improved the markers of renal injury induced by CKD. In addition, CORM3 or NaHS significantly improved CBS expression which wasreduced by CKD. However, improving effects of CORM3 on antioxidant defense mechanisms, lipid peroxidation, neuronal death, renal injury, and CBS expression was prevented by amino-oxy acetic acid (AOAA) (CBS inhibitor) and reciprocally improving effects of NaHS on all above indices were prevented by zinc protoporphyrin IX (Znpp) (HO-1 inhibitor). In conclusion, this study demonstrated that the formation of CO and H2S interdependently improved CKD-induced oxidative stress and neuronal death, which may bethrough increased expression of CBS.
The Use of “Damage Control Orthopedics” Strategy in the Treatment of Severe Gunshot Wounds of the Limbs
Authors: Domanskyi Andriy , Tomilin Valerii , Tomilin Mykyta
Published: January 2023

Objectives. The objectives of this study were to evaluate the incidence and nature of gunshot wounds of the limbs in the general structure of combat trauma, and study the features of DCO (Damage Control Orthopedics) patient management strategy in the conditions of a regional hospital as a stage of care for this pathology. Background. Limb injuries account for between 52.3% and 60.1% of combat casualties. The problem of surgical management of limb gunshot wounds is of particular relevance at the present stage of active use of firearms. Thus, adequate choice of surgical treatment strategy for limb gunshot wounds is an important condition for preserving life and preventing severe complications in combat casualties. Methods. The study was conducted among 1000 injured from the combat zone during the period from 24.02.22 to 15.04.22. The trauma and orthopedic surgery department of "Dnipropetrovsk Regional Clinical Hospital named after I.I. Mechnikov" mainly performed secondary surgical debridement of wounds, comprehensive surgical and medical prevention of complications in the injured. Injury severity was assessed using the ISS (Injury Severity Score) based on the AIS (Abbreviated Injury Scale), which assesses the severity of injuries to several areas of the body. Results. DCO strategy was used in 287 (55.1%) injured patients in severe and extremely severe condition (16 points or higher on the ISS scale). A total of 602 surgical operations were performed in 287 injured patients. On average, 2.1 ± 0.6 interventions per one injured person were performed. Overall mortality among victims with gunshot wounds of the limbs was 3.6% (19 wounded out of 521). In all cases there were polytrauma (100%), in 4 (21.1%) cases they were through-and-through injuries, in 2 (10.5%) - with the compartment syndrome development. Conclusions. Differentiated DCO strategy in the surgical treatment of the critically and severely injured (16 points and above on the ISS scale) are essential to save the lives of soldiers in the first period of traumatic illness and to prevent complications of the second and third periods of traumatic illness.
Genetic Risk Assessment of Lethal Prostate Cancer Using Polygenic Risk Score and Hereditary Cancer Susceptibility genes
Authors: Ruan Xiaohao , Huang Da , Huang Jingyi , Tsu James Hok-Leung , Na Rong
Published: January 2023

Background
The genetic risk of aggressive prostate cancer (PCa) is hard to be assessed due to the lack of aggressiveness-related single-nucleotide polymorphisms (SNPs). Prostate volume (PV) is a potential well-established risk factor for aggressive PCa, we hypothesize that polygenic risk score (PRS) based on benign prostate hyperplasia (BPH) or PV-related SNPs may also predict the risk of aggressive PCa or PCa death.
Methods
We evaluated a PRS using 27 BPH/PV-associated SNPs, two established PCa risk-related PRS and 10 guideline-recommended hereditary cancer risk genes in the population-based UK Biobank cohort (N = 209,910).
Results
The BPH/PV PRS was significantly inversely associated with the incidence of lethal PCa as well as the natural progress in PCa patients (hazard ratio, HR = 0.92, 95% confidence interval [CI]: 0.85–0.99, P = 0.03; HR = 0.92, 95%CI: 0.86–0.99, P = 0.02). Compared with men at top 25th PRS, PCa patients with bottom 25th PRS would have a 1.40-fold (HR, 95%CI: 1.16–1.69, P = 0.001) increased PCa fatal risk and shorter survival time at 0.37 year (95%CI: 0.14–0.61, P = 0.002). In addition, patients with BRCA2 or PALB2 pathogenic mutations would also have a high risk of PCa death (HR = 3.91, 95%CI: 2.34–6.51, P < 0.001; HR = 4.24, 95%CI: 1.34–13.34, P = 0.01, respectively). However, no interactive but independent effects were detected between this PRS and pathogenic mutations.
Conclusions
Our findings provide a new measurement of PCa patients’ natural disease outcomes via genetic risk ways.
recO enhances resistance of Pasteurella multocida to fluoroquinolones
Authors: Li Xue-song , Xue Jun-ze , Qi Yu , Hu Ren-ge , Muhammad Inam , Gao Yun-hang , Wu Tong-lei , Kong Ling-cong , Ma Hong-xia
Published: January 2023

Pasteurella multocida capsular type A (PmA) is one of the main pathogens causing bovine respiratory disease in China. The prevention and control measures against Pm are traditionally based on the use of broad-spectrum antibiotics. Previous studies found that Pm was prone to antibiotic resistance and tolerance mutation under the action of low concentrations of antibiotics, ultimately causing difficulties in prevention and control against Pm. In this study, highly pathogenic Pm fluoroquinolone-sensitive strain P3 and fluoroquinolone-resistant strain P32 induced by sub-inhibitory concentration of enrofloxacin were selected as research objects. RNA-seq was used to screen the differential gene recO of SOS response of P3 and P32 for functional verification. In addition, through MIC, MBC, induced resistance time, time-kill curve analysis and antibiotic tolerance test, the effect of recO gene on the resistance and tolerance of Pm to fluoroquinolone was clarified. At the same time, using fluorescent reporter vector, it was found that recO gene affected SOS repair response. In conclusion, the inhibition of recO gene can not only reduce their resistance to fluoroquinolone, but also prolong the formation time of fluoroquinolone resistance. It is speculated that recO gene is a potential target of fluoroquinolone synergistic antibacterial agent.
“I am scared, I do not want to lie”: Exploring the impacts of COVID-19 on engagement in care, perceived health, relationship dynamics, and parenting among postpartum women with HIV in South Africa
Authors: Stanton Amelia M. , Blyler Abigail P. , Mosery Nzwakie , Goodman Georgia R. , Vanderkruik Rachel , Sithole Kedibone , Bedoya C. Andres , Smit Jennifer , Psaros Christina
Published: January 2023

Background
COVID-19 and efforts to manage widespread infection may compromise HIV care engagement. The COVID-19-related factors linked to reduced HIV engagement have not been assessed among postpartum women with HIV, who are at heightened risk of attrition under non-pandemic circumstances. To mitigate the effects of the pandemic on care engagement and to prepare for future public health crises, it is critical to understand how COVID-19 has impacted (1) engagement in care and (2) factors that may act as barriers to care engagement.
Methods
A quantitative assessment of COVID-19-related experiences was added to a longitudinal cohort study assessing predictors of postpartum attrition from HIV care among women in South Africa. Participants (N = 266) completed the assessment at 6, 12, 18, or 24 months postpartum between June and November of 2020. Those who endorsed one or more challenge related to engagement in care (making or keeping HIV care appointments, procuring HIV medications, procuring contraception, and/or accessing immunization services for infants; n = 55) were invited to complete a brief qualitative interview, which explored the specific factors driving these challenges, as well as other impacts of COVID-19 on care engagement. Within this subset, 53 participants completed an interview; qualitative data were analyzed via rapid analysis.
Results
Participants described key challenges that reduced their engagement in HIV care and identified four other domains of COVID-19-related impacts: physical health, mental health, relationship with a partner or with the father of the baby, and motherhood/caring for the new baby. Within these domains, specific themes and subthemes emerged, with some positive impacts of COVID-19 also reported (e.g., increased quality time, improved communication with partner, HIV disclosure). Coping strategies for COVID-19-related challenges (e.g., acceptance, spirituality, distraction) were also discussed.
Conclusions
About one in five participants reported challenges accessing HIV care, medications, or services, and they faced complex, multilayered barriers to remaining engaged. Physical health, mental health, relationships with partners, and ability to care for their infant were also affected. Given the dynamic nature of the pandemic and general uncertainty about its course, ongoing assessment of pandemic-related challenges among postpartum women is needed to avoid HIV care disruptions and to support wellbeing.
The analgesic effect of total intravenous anaesthesia with propofol versus inhalational anaesthesia for acute postoperative pain after hepatectomy: a randomized controlled trial
Authors: Wong Sau-ching Stanley , Wang Fengfeng , Chan Chi Wing Timmy , Cheung Chi Wai
Published: January 2023

Background Postoperative pain control can be challenging in patients undergoing hepatectomy. A previous retrospective study on hepatobiliary/ pancreatic surgeries showed better postoperative pain control in patients who received propofol TIVA. The aim of this study was to determine the analgesic effect of propofol TIVA for hepatectomy. This clinical study has been registered at ClinicalTrials.gov (NCT03597997). Methods A prospective randomized controlled trial was performed to compare the analgesic effect of propofol TIVA versus inhalational anaesthesia. Patients aged between 18 and 80 years old with an American Society of Anesthesiologist (ASA) physical status of I-III scheduled for elective hepatectomy were recruited. Ninety patients were randomly allocated to receive either propofol TIVA (TIVA group) or inhalational anaesthesia with sevoflurane (SEVO group). Perioperative anaesthetic/analgesic management was the same for both groups. Numerical rating scale (NRS) pain scores, postoperative morphine consumption, quality of recovery, patient satisfaction and adverse effects were evaluated during the acute postoperative period and at 3 and 6 months after surgery. Results No significant differences were found for acute postoperative pain scores (both at rest and during coughing) and postoperative morphine consumption between TIVA and SEVO groups. Patients given TIVA had lower pain scores with coughing at 3 months after surgery (p = 0.014, and FDR < 0.1). TIVA group was associated with better quality of recovery on postoperative day (POD) 3 (p = 0.038, and FDR < 0.1), less nausea (p = 0.011, and FDR < 0.1 on POD 2; p = 0.013, and FDR < 0.1 on POD 3) and constipation (p = 0.013, and FDR < 0.1 on POD 3). Conclusion Propofol TIVA did not improve acute postoperative pain control compared to inhalational anaesthesia in patients who underwent hepatectomy. Our results do not support the use of propofol TIVA for reducing acute postoperative pain after hepatectomy.
The first report of co-infection with Sphaerirostris picae and Ascaridia galli in the Oriental magpie (Pica serica) in Beijing, China
Authors: Hu Bin , Wang Jiamin , Wang Ye , Li Yi , wang Bo , Xiang Chen , Xing Yanan , Han shuyi , Yuan Guohui , He Hongxuan
Published: January 2023

Background
As a wild bird adapted to urban pressures, the Oriental Magpie (Pica serica) can carry a variety of pathogenic microorganisms that affect public health and safety. Sphaerirostris picae and Ascaridia galli can be parasitic in the digestive tract of wild birds and are transmitted between hosts. In this study, we identified nematode species in the intestinal tract of Oriental magpie in Beijing, China, revealing the health threats posed by parasitic worms to urban birds and the potential public health risks posed to humans and other animals.
Results
Sphaerirostris picae and Ascaridia galli isolated from the intestinal tract of Oriental magpie in Beijing. Morphological characteristics of the parasites were observed by stereoscopic microscope and scanning electron microscope, and phylogenetic relationships of the parasites were analyzed by sequencing the COX1 gene.
Conclusions
To our knowledge, this is the first study to show the presence of Sphaerirostris picae infection in magpies in China and the first report of co-infection of the two parasites in wild birds, confirming the epidemiological role of urban birds in public health.
Screening transcription factors of IbMYB1-4 by yeast one-hybrid assays in purple-fleshed sweet potato
Authors: Fu Danwen , Yang Shaohua , Liu Rui , Gao Feng
Published: January 2023

The transcription factor IbMYB1 has been identified to be involved in anthocyanin biosynthesis in purple-fleshed sweet potato. However, the upstream transcription factors of PIbMYB1-4 involved in anthocyanin biosynthesis have rarely been studied. In this study, yeast one-hybrid screen was conducted in purple-fleshed sweet potato storage roots to identify upstream transcription factors of PIbMYB1-4. Three proteins, IbERF1, IbPGP19 and IbPDC, were screened as the upstream binding proteins of PIbMYB1-4. Yeast one-hybrid assays and luciferase reporter assays were used to verify that upstream binding proteins interacted with the promoters. The interaction between the promoters and upstream binding proteins was verified by yeast one-hybrid and luciferase reporter assays. The gene expression of upstream transcription factors, transcription factors and structural genes involved in anthocyanin biosynthesis in different root stages of purple-fleshed and white-fleshed sweet potato was analyzed by real-time PCR. IbERF1 has been identified as the upstream transcription factor of PIbMYB1 involved in anthocyanin biosynthesis in purple-fleshed sweet potato. It has been identified that IbERF1 plays an important role in anthocyanin biosynthesis in purple-fleshed sweet potato.
Federated learning for feature-fusion based requirement classification
Authors: wang Ruiwen , Liu Jihong
Published: January 2023

With the increasing complexity of products, the utilization of automated requirements classification in the process of requirement engineering is of positive significance to improve the efficiency of product development. There have been many experiments on the requirements classification based on artificial intelligence. However, many studies only use a single feature in semantic features or statistical features to classify requirements and put forward the problem of small-scale requirement datasets caused by the confidentiality of requirement data, which limits the application research of requirement classification in a large number of fields. Therefore, we propose a requirement classification model that integrates semantic and statistical features, and design a federated learning framework based on knowledge distillation without centralized servers in a ring architecture. In this paper, we extract a large amount of requirement data from a large number of requirement documents, and conduct experiments in the centralized learning environment and the federated learning environment respectively. The final experimental results show that our method can maintain the confidentiality of the requirement data and improve the communication efficiency in the process of model training with a slight decrease in the effect of requirement classification compared with centralized learning.
Predominant Antibody Deficiency and Risk of Microscopic Colitis: A Nationwide Case-Control Study in Sweden
Authors: DiGiacomo Daniel V , Roelstraete Bjorn , Hammarström Lennart , Farmer Jocelyn R , Khalili Hamed , Ludvigsson Jonas F.
Published: January 2023

Purpose
Predominant antibody deficiency (PAD) disorders, including common variable immunodeficiency (CVID), have been linked to increased risk of gastrointestinal infections and inflammatory bowel diseases. However, there are limited data on the relationship between PAD, specifically CVID, and risk of microscopic colitis (MC).
Methods
We performed a nationwide case-control study of Swedish adults with MC diagnosed between 1997 and 2017 (n = 13,651). Data on biopsy-verified MC were retrieved from Sweden’s all 28-pathology departments through the Epidemiology Strengthened by histoPathology Reports in Sweden (ESPRESSO) study. We defined predominant antibody deficiency using International Union of Immunologic Societies (IUIS) phenotypic classification. Individuals with MC were matched to population controls by age, sex, calendar year, and county. We used logistic regression to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).
Results
The prevalence of PAD in MC was 0.4% as compared to 0.05% in controls. After adjustment for potential confounders, this corresponded to an aOR of 7.29 (95%CI 4.64–11.63). The magnitude of the association was higher for CVID (aOR 21.01, 95% 5.48-137.44) compared to other antibody deficiencies (aOR 6.16, 95% CI 3.79–10.14). In exploratory analyses, the association between PAD and MC was particularly strong among males (aOR 31.73, 95% CI 10.82-135.04).
Conclusion
In this population-based study, predominant antibody deficiency was associated with increased risk of MC, particularly among males. Clinicians who encounter these patients should consider a detailed infectious history and screening for antibody deficiency.
Development and Evaluation of a Predictive Diagnostic System for Dengue Fever using Machine Learning Techniques
Authors: Khan Jibran Rasheed , Farooqui Sehan Ahmed , Raza Syed Kawish , Siddiqui Farhan Ahmed
Published: January 2023

As the world continues to evolve scientifically and climatically, the medical and healthcare sectors face new challenges in the form of newly identified diseases, insects, chemicals, and environmental effects. These new challenges are often more complex and dangerous than existing conditions, and require prompt diagnosis and appropriate treatment to prevent loss of life. This paper presents a study on the development of a presumptive diagnosis system (PDS) for early dengue fever detection. The proposed system aims to assist medical professionals in determining the disease at an early stage and help unprofessional or new staff to learn and experiment better. The PDS utilizes machine learning algorithms such as Decision Tree (DT), Random Forest (RF), and Naive Bayes (NB), along with their combination, to classify dengue fever and its types. The dataset used in this study consisted of 400 records of 15 attributes, and the data was preprocessed to reduce noise, incompleteness and inconsistencies. The classification results showed that the PDS achieved an average accuracy of 95.6%, with the highest individual accuracy achieved by RF, DT and NB being 98%, 97% and 87% respectively. Our results demonstrate that PDS can facilitate the diagnostic process in resource-limited settings by providing an alternative to hardware-intensive solutions. Furthermore, the system can aid healthcare professionals in making early and accurate diagnoses, and can also serve as a learning tool for new staff.
BTN1A1 is a novel immune checkpoint mutually exclusive to PD-L1
Authors: Yoo Stephen , Kim Young Seung , Park Andrew , Wu Chunai , Lin Steven H. , Jung Hyunjin
Published: January 2023

While PD-1/PD-L1 blockade is a potent antitumor treatment strategy, it is effective in only limited subsets of cancer patients, emphasizing the need for the identification of additional immune checkpoints. Butyrophilin 1A1 (BTN1A1) has been reported to exhibit potential immunoregulatory activity, but its ability to function as an immune checkpoint remains to be systematically assessed and the mechanisms underlying such activity have yet to be characterized. Here, BTN1A1 expression was validated in primary tumor tissue samples, and its ability to suppress T cell activation and T cell-dependent tumor clearance was examined. The relationship between BTN1A1 and PD-L1 expression was further characterized, and an anti-BTN1A1 antibody was developed and administered to tumor-bearing mice to test the amenability of this target to immune checkpoint inhibition. BTN1A1 was confirmed to suppress T cell activation in vitro and in vivo. Robust BTN1A1 expression was detected in a range of solid tumor tissue samples, and BTN1A1 expression was mutually exclusive with that of PD-L1 as a consequence of its inhibition of JAK/STAT signaling-induced PD-L1 upregulation. Antibody-mediated BTN1A1 blockade suppressed tumor growth and enhanced immune cell infiltration in syngeneic tumor-bearing mice. Together, these results confirm that BTN1A1 is a bona fide immune checkpoint and viable immunotherapeutic target for the treatment of anti-PD1/PD-L1 refractory or resistant patients, opening new avenues to improving survival outcomes for patients with a range of cancers.
Silent Sinus syndrome- should we be concerned?
Authors: Gupta Ashana , Ganesan Kandasamy
Published: January 2023

In this paper, we report on the radiological findings of silent sinus syndrome. This is significant because silent sinus syndrome can lead to enophthalmos, facial asymmetry and diplopia if left untreated. It is usually diagnosed based on radiological findings. Patients normally present to the head and neck specialty for unrelated concerns and upon taking radiographic imaging, features of silent sinus syndrome can be seen. It is the duty of the surgeon to be aware of sinus abnormalities and inform the patient of such findings. This paper highlights the radiological features clinicians should be aware of. Clinical relevance: Radiologists and head and neck clinicians should be aware of the features of silent sinus syndrome. The syndrome is poorly reported on but radiological features are consistent across case reports. Objectives: The reader should have an awareness of the radiological signs of maxillary sinus pathology and understand features of silent sinus syndrome. They should be able to Include sinus related findings in radiographic report for orbito-facial imaging.
Occipital neuralgia after COVID-19 vaccination: a report of two cases
Authors: Malheiro Sofia , Costa Diogo , Varela Ricardo
Published: January 2023

BACKGROUND
A wide range of neurological complications has been described following the administration of COVID-19 vaccinations, with headache being the most commonly reported neurological adverse effect, with higher incidence after the second dose. The most common headache is a dull pain or migraine like. Still, two cases of trigeminal neuralgia and a case series of 7 patients with cluster headache who were clinically stable and had a new episode a few days after COVID-19 vaccination have also been reported. Herein, we describe the first two cases of occipital neuralgia developing after COVID-19 vaccination.
CASES PRESENTATION
Two cases were observed in the neurology outpatient clinic of a tertiary university referral center in Portugal between October 2021 and June 2022. Both patients developed the headache within 1 to 6 days after the second dose of BNT162b2 (Pfizer). One had no previous history of headaches, and the other had a migraine that was clearly different from the present headache. Each case is described, checked for ICHD criteria for occipital neuralgia, and its temporal relation with COVID-19 Vaccination is reported.
CONCLUSIONS
COVID-19 vaccination can trigger various types of headaches, far beyond the most commonly described feature of dull pain, possibly by activating an immune-inflammatory response.
Novel therapeutic targets identification of Delftia tsuruhatensis strain TR1180 employing subtractive genomics approach
Authors: Mahmood Sajjat , Shihab Md Maksudur Rahman , Rashid Afsara Binte , Imu Ishrat Jahan , Nawer Narmin , Karim Md. Hasanul
Published: January 2023

Delftia tsuruhatensis is an opportunistic pathogen, that causes human infection in immunocompromised individuals. The organism was found to be infectious in the respiratory tract and urinary tract infections. Isolation of D. tshuruhatensis showed resistance to common antibiotics, resulting in an alarming signal from the pathogen. Importantly, the D. tshuruhatensis strain was found to have the property of having IMP-1 Metallo-β-Lactamase, which could hydrolyze β-lactam antibiotics. To combat the challenge of antibiotic resistance, novel drug targets can be effective. For suggesting the novel drug targets, the entire proteome of D. tshuruhatensis strain TR1180 was subjected to subtractive genomic analysis using a variety of bioinformatic tools and servers. To identify human homologue proteins of the pathogen and proteins involved in common metabolic pathways between the pathogen and host, various bioinformatics tools and web servers were used. Only 62 proteins were found to be linked to pathogen-specific pathways; these proteins were then further screened to single out membrane-antigenic proteins that could be targeted by medications or vaccines. The novel therapeutic targets with the highest level of antigenicity were discovered to be ‘Nitrate transporter’ and ‘Phospho-N-acetylmuramoyl-pentapeptide-transferase’.
The collagen enhancement by spirulina extract in intrinsic and extrinsic skin aging in albino rat
Authors: Sharafeldein Khaled , Ayesh Hanan , Salama Safwat , Marei Azza
Published: January 2023

The aging of the skin is considered a cumulative process that is classed as intrinsic or extrinsic. Environmental factors like sun exposure and air pollution are considered the main cause of extrinsic aging. Mainly, intrinsic aging reflects the genetic background and depends on time. Spirulina platensis unicellular blue-green algae have a variety of biological and nutritional activities because of their high level of nutrients. The current study aims to investigate the mechanism by which spirulina extract (SE) may act anti-aging in female albino rats. Animals were received SE only, UV radiation only and both. In addition, two intrinsic groups as control old and old rats received SE. Spirulina extract (20mg/mL) was injected subcutaneously before UVA irradiation (2.16 J/cm2), daily for 7 days. The epidermal thickness and the collagen fibers layer were stained utilizing Hematoxylin and Eosin and Masson. There were improvements in the activities of antioxidants including superoxide dismutase (SOD) and reduced glutathione (GSH), downregulating in expressions of inflammatory cytokines; Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). As well as the recovery of collagen density, and reducing the production of matrix metalloproteinases were presented. The results found that spirulina extract may delay the signs of skin aging by enhancing collagen production as well as antioxidant activities and inhibiting collagen degradation and inflammation.
Linguistic profile in children with a double diagnosis of attention deficit and hyperactivity disorder and developmental language disorder
Authors: Moraleda-Sepúlveda Esther , López-Resa Patricia , Pulido-García Noelia
Published: January 2023

Recently, comorbidity and the number of double diagnosis cases of attention deficit hyperactivity disorder (ADHD) and developmental language disorder (DLD) have increased. This study aimed to know the linguistic profile that the children of such cases present. Our sample included 24 participants between 6–11 years old, divided into three groups: ADHD; DLD; double diagnosis of ADHD and DLD. We administered the Celf-4 Language Test with the areas: core language, receptive language, expressive language, language content, language memory and working memory. Our results revealed that the children with double diagnosis performed better than individuals with DLD in Core Language, Expressive Language and Language Memory, but worse than the children with ADHD. These data demonstrate that the presence of DLD determines linguistic differences. The coexistence of ADHD does not predispose to having a different linguistic profile.
Studies of Distribution and Drug Resistance of Biofilm Bacteria and the Influencing Factors of Upper Urinary Calculi Patients with Double J Stent Indwelling
Authors: Chen Qian , Ye JunBing , Zeng Ke , Li Xiao Bin , Zeng Shiping
Published: January 2023

Objective: To analyze the distribution and drug resistance of biofilm bacteria infected with upper urinary calculi patients with double J stent indwelling and its influencing factors.
Methods: A total of 400 patients with upper urinary calculi who adopted double J stent inserting in our hospital from January 2019 to January 2022 were included. The urine and double J stent samples were collected and pathogen culture were performed, and the drug sensitivity test analysis were carried out for isolates.Univariate and multivariate logistic regression analyses were used to analyze the influencing factors of patients with double J-stent associated biofilm bacteria infections.
Results: A total of 13 strains (3.2%) of biofilm bacteria were detected from urine samples and 168 strains (42%) from double J-stent samples (P < 0.05), 95 strains (23.7%) of pathogenic bacteria were separated from urine samples and 117 strains (29.2%) from double J-stent samples (P > 0.05). Escherichia coliwere the most common bacteria. there were significantly higher drug resistance was observed in biofilm bacteria versus urine-cultured pathogens (P < 0.05). Advanced age, long-term catheterization, insufficient water intake, hypoproteinemia, abnormal renal function and diabetes mellitus were independent risk factors for biofilm bacteria infection associated with double J stent(P < 0.05).
Conclusion: Among the upper urinary calculi patients with double J stent indwelling, the positive rate and drug resistance of biofilm bacteria obtained from double-J stent were significantly higher than that from urine.Deem that rational choice of antibiotics and appropriate treatment led to better prognosis.
Volume monitoring of the milling tool tip wear and breakage based on multi-focus image three-dimensional reconstruction
Authors: Peng Yeping , Qin Shucong , Wang Tao , Hu Yixi , Nie Shiping
Published: January 2023

In precision machining, the milling tool’ geometry has a great influence on the milled surface quality. The research on milling tool state monitoring was mainly based on one-dimensional signals and two-dimensional images, which could indirectly obtain the tool state and wear area, but it could not provide the volume of milling tool wear and breakage area, thereby making it difficult to achieve quantitative analysis tool wear. This paper proposed a three-dimensional (3D) reconstruction method of the milling tool tip, it could build a 3D model of the milling tool tip, and then the volume of the wear and breakage region of the milling tool tip was extracted by the 3D model. Firstly, the focusing degree of image sequence’s pixels was calculated based on the non-subsampled discrete shearlet transform (NSST) and Laplace algorithm, and the 3D reconstruction of the milling tool tip was completed according to the shape-from-focus (SFF) principle; secondly, the depth values were optimized by fitting the focusing degree curve of pixels in the image sequence with Gaussian function; finally, the volume of the 3D point cloud of the milling tool tip was calculated by the Simpson double numerical integration method, and the material loss in the damaged region could be obtained. In the 3D reconstruction experiment of the milling tool tip, comparing the different focus degree evalution operators of SFF, the 3D point cloud obtained by this paper's proposed 3D reconstruction method has the least noise and the best performance in the root-mean-square error, correlation, and smoothness indexes. In addition, compared with Genmagic software, the 3D point cloud volume calculation method adopted in this paper could accurately calculate the 3D point cloud volume of the milling tool tip, and the percentage error was less than 1%.
A novel wheel path generation approach for grinding taper end-mills subject to adaptive cross-section
Authors: Wang Liming , Yang Jianping , Fang Yang , Zhu Jiang , Li Jianfeng
Published: January 2023

Taper end-mills are widely used in CNC machining and the flute are crucial to the cutting performance of the end-mill. However, it is very difficult to form the wheel path of grinding taper end-mill due to its complex structure and variable cross-section. In the traditional methods, the wheel path is generated by experience, and the accuracy of flute parameters cannot be guaranteed. To overcome those problems, this paper proposed a wheel path generation approach for taper end-mills flute-grinding subject to adaptive cross-section, which is capable to ensure the accuracy of parameters of variable cross-section. In the wheel path generation, the taper end-mill is discretized into a series of finite slices, which can be transformed into solving a series sub-problem of grinding cylindrical end-mills. To eliminate the interference and discontinuity caused by the discretization, the enhancement based on sensitivity analysis and smoothing method are used to optimize the grinding wheel path. Finally, the approach is validated by both simulation and experiments. The results indicated that this approach is capable to generate the wheel path for grinding the taper end-mill flute accurately and efficiently subject to the adaptive cross-section parameters.
Scent detection of Brucella abortus by African giant pouched rats (Cricetomys ansorgei).
Authors: Mwampashi Raphael , Cutright Ellie , Fast Cynthia D. , Bonfoh Bassirou , Kazwala Rudovick R. , Mathew Coletha
Published: January 2023

Background Brucellosis is a contagious zoonosis caused by Brucella bacterium. While the disease has been eradicated in most developed countries, it remains endemic in sub–Saharan Africa where access to reliable diagnostics is limited. African giant pouched rats (Cricetomys ansorgei) have been trained to detect the scent of Mycobacterium tuberculosis to increase case detection in sub-Saharan Africa. Given the similar diagnostic challenges facing brucellosis and tuberculosis, we explored the feasibility of training African giant pouched rats to detect Brucella.
Results After 3 months of training, rats reliably identified cultured Brucella, achieving an average sensitivity of 93.56% (SD = 0.650) and specificity of 97.65% (SD = 0.016). Rats readily generalized to novel, younger Brucella cultures that presumably generated a weaker volatile signal and correctly identified at least one out of three fecal samples spiked with Brucella culture during a final test of feasibility.
Discussion To our knowledge, these experiments are the first to demonstrate Brucella emits a unique odor profile that scent detection animals can be trained to identify. Importantly, cultured E. colisamples were included throughout training and test to ensure the rats learned to specifically identify Brucella bacteria rather than any bacteria in comparison to bacteria-free culture medium. E. coli controls therefore served a crucial function in determining to what extent Brucella abortus emits a unique odor signature. Further research is needed to determine if a Brucella-specific volatile signature is present within clinical samples. If confirmed, the present results suggest trained rats could serve as a valuable, novel method for the detection of Brucellainfection.
Synopsis of myxosporean species (Cnidaria: Myxozoa) parasitizing fishes from Vietnam
Authors: Chinh Nguyen Ngoc , Ha Nguyen Thi Hoang , Doanh Pham Ngoc , Eiras J. C. , Whipps Christopher M. , Shirakashi Sho
Published: January 2023

This paper provides an update checklist of species-level identified myxosporean species from marine and freshwater fishes in Vietnam. The list includes 51 nominal myxosporean species (38 marine and 13 freshwater) belonging to 9 genera: Myxobolus (26 species); Kudoa (6 species); Henneguya (6 species); Thelohanellus (5 species); Unicapsula (2 species); Ceratomyxa (2 species), Zschokkella (2 species); Auerbachia (1 species), and Meglitschia (1 species). For each parasite species, information on morphological characteristics of myxospore, fish hosts, infection sites, and collection locality in Vietnam along with GenBank accession number of nucleotide sequence data and the line drawings were provided. In addition, taxonomic status of several species was discussed and Myxobolus eszterbaueri nom. nov. is proposed as a junior homonym for Myxobolus hakyi Baska, Voronin, Eszterbauer, Müller, Marton & Molnár 2009.