bluuebunny/crossref_metadata_2025 huggingface dataset:
Cerebrovascular Function in Migraine Patients during, their Interictal Period, Compared to Normal Healthy Controls
Authors: Conway Miriam Louise , Ctori Irene
Published: December 2022

Background: Migraine is a debilitating neurovascular disorder which primarily impacts the working age population. The aim of the study was to determine if transient hemodynamic alterations during each migraine attack translates into cerebrovascular alterations, during migraineurs interictal period. A secondary hypothesis was to determine if there was any relationship between vascular hemodynamics and either the severity or frequency of migraine attacks.Methods: We recruited 29 volunteers: 13 migraineurs (mean age 28±8.8 years; 12 female and 1 male) and 16 age-matched controls (mean age 26.6±6.9; 9 female and 7 male). Volunteers were classified as migraine sufferer or not (control group). All individuals underwent a detailed ophthalmic examination by a qualified optometrist and a Migraine Disability Assessment. Cerebral blood velocity measurements for the Middle Cerebral Artery (MCA) and Vertebral Artery (VA) were obtained using Colour Doppler Imaging using the Hitachi Aloka Noblus ultrasound system. The investigators were blind to the migraine diagnosis.Results: During their interictal period migraineurs appear to have no significant difference in any hemodynamic parameter, for either their MCA and VA, when compared to normal healthy controls. Neither was a significant relationship between Migraine Disability Assessment Scores and any vascular parameter reported.Conclusion: This study found nil cerebrovascular alterations which could be measured in migraineurs compared to normal healthy controls, during their interictal period.
Steroid-Responsive Cerebral Vasculitis in Systemic Lupus Erythematosus with Sulcal Hyperintensities
Authors: Kim Hongil , Park Hong-Kyun , Kim Young Seo
Published: December 2022

The clinical manifestations of cerebral lupus vasculitis have a wide spectrum of severity which can result in different prognoses. Therefore, its diagnosis and treatment remain challenging without specific guidelines. A 49-year-old woman with systemic lupus erythematosus presented with transient left side paresthesia and dysarthria lasting 20 minutes. Brain magnetic resonance imaging (MRI) showed a multifocal diffusion restriction and sulcal hyperintensities in the right middle cerebral artery region. Brain magnetic resonance angiography (MRA) showed multifocal steno-occlusive lesions at her intracranial arteries. Because she only showed transient symptoms, aspirin (100 mg/day), atorvastatin (20 mg/day) and an increased dose of prednisolone (5 mg/day to 10 mg/day) were started, on the suspicion of cerebral lupus vasculitis. Brain MRIs/MRAs renormalized after four months without any recurrence. Cerebral lupus vasculitis manifests diverse clinical and neuroimaging characteristics. Although brain image demonstrates devastating features, tailored immune therapy should be selected based on the severity of the patient’s symptoms.
Recurrent Neuropsychiatric Systemic Lupus Erythematosus Presenting with Primary Central Nervous System Lymphoma
Authors: Song Jun Kyu , Bae Sang-Cheol , Kim Young Seo , Kim Hyun Young
Published: December 2022

We report the case of a systemic lupus erythematosus (SLE) patient who was diagnosed with lupus cerebritis, vasculitis, Epstein-Barr virus infection, and consequently, lymphoma. The patient presented to the emergency department with dysarthria, dysphagia, left-sided hemiparesis, and hypesthesia. Initial brain magnetic resonance imaging (MRI) revealed multiple high signal intensities in the cortex and subcortex. Intravenous methylprednisolone and immunoglobulin administration did not improve her symptoms. However, intravenous rituximab improved the parenchymal and angiographic abnormalities. One month later, she developed another acute left-sided hypesthesia. Brain MRI revealed multiple rim-enhancing lesions with perilesional edema, different from the previous lesion. Intravenous methylprednisolone and cyclophosphamide did not improve her symptoms, and she was finally diagnosed with primary central nervous system lymphoma after brain biopsy. Neurological symptoms improved after chemotherapy. Since the incidence of primary central nervous lymphoma is relatively high in SLE patients, careful diagnosis and accurate treatment are needed.
Recurrent Cerebral Infarction due to Cerebral Vasculitis in a Patient with Ulcerative Colitis
Authors: Joo Jae Young , Lee Kyung Mi , Noh Kyung Chul , Park Sangil , Woo Ho Geol , Chang Dae-il , Heo Sung Hyuk
Published: December 2022

Vascular complications are extraintestinal manifestations of ulcerative colitis. Although there has been some controversy regarding the association between ulcerative colitis and stroke, hypercoagulability and systemic inflammation are thought to be possible factors contributing to stroke pathogenesis. Herein, we report a case of recurrent ischemic stroke with significant arterial stenosis. Cerebral vasculitis was suggested in high-resolution magnetic resonance vessel wall imaging (VWI) and marked improvement was confirmed by follow-up VWI after steroid treatment. This case suggests that VWI can be a useful tool to diagnose cerebral vasculitis and evaluate therapeutic effect.
Mémoire et autobiographie dans l’œuvre de Claude Simon
Authors: Belarbi Mokhtar
Published: December 2022

La mémoire occupe une place privilégiée dans l’œuvre de Claude Simon. À travers Les Géorgiques, L ’Acacia et Le Jardin des plantes, notre but, dans le présent article, est de montrer qu’il n’a pas cherché à rédiger une « autofiction » ou un « roman historique », mais à écrire une autobiographie littéraire. Son objectif ultime n’était pas de « retrouver le temps perdu », mais d’inscrire « le temps perdu » dans la littérature. Il résulte de cette étude que la nouvelle forme de l’autobiographie initiée par Claude Simon se démarque entièrement de l’autobiographie classique. Elle est écrite par le recours inlassable de l’écrivain à des stimuli, c’est-à-dire par le questionnement de textes écrits par des personnes, qui se sont trouvées dans des situations similaires. Elle est une auto-sensorio-graphie : l’écriture s’appuie essentiellement sur la description de la sensation et non des faits rapportés. Elle est par ailleurs une auto-thanato-graphie, puisque la mort y est le personnage central.
Cambodge, me voici : trauma, post-mémoire et construction d’un espace culturel féminin dans le théâtre parlé de Jean-Baptiste Phou
Authors: Do Tess , Zhang Darren
Published: December 2022

Plus de quarante ans après la fin du régime Khmer rouge, le poids du génocide pèse encore sur la diaspora franco-cambodgienne. Confronté au silence des aînés qui refusent de parler du passé génocidaire, Jean-Baptiste Phou recourt au théâtre parlé khmer pour donner la parole à quatre femmes cambodgiennes et mettre en scène leur parcours. Dans cet essai nous proposons de lire Cambodge, me voici à la lumière de la post-mémoire de Marianne Hirsch. Le croisement des axes de désir des protagonistes et la création d’un espace familial, féminin et maternel nous permettront d'analyser la formation de la mémoire diasporique des femmes et les modalités de sa transmission intra- et intergénérationnelle à travers deux couples, sororal et mère-fille. Nous postulons que le choix du casting et la mise en scène des deux versions française et khmère de la pièce transforment l’espace scénique en un lieu de partage mémoriel dans lequel se révèle le rôle de réparatrice et de passeuse culturelle attribué aux femmes.
မြန်မာနိုင်ငံ၏ သဘာဝပတ်ဝန်းကျင်နှင့် ရာသီဥတုပြောင်းလဲမှုဆိုင်ရာ စိန်ခေါ်မှုများ
Authors: Hickey Sharon P. , Maria-Sube Elodie
Published: December 2022

မြန်မာနိုင်ငံသည် သဘာဝသယံဇာတ ပေါများကြွယ်ဝကာ ကမ္ဘာပေါ်တွင် ဇီဝမျိုးစုံမျိုးကွဲများ များပြားစုံလင်ရာ ဒေသတစ်ခုဖြစ်သည်။ ထို့ပြင် မြန်မာနိုင်ငံသည် ရာသီဥတုပြောင်းလဲမှုဒဏ်ကို အဆိုးရွားဆုံး ခံစားရပြီး ပြည်ပအထောက်အပံ့များမပါဘဲ ၎င်း၏ဒဏ်ခံနိုင်စွမ်းကို မြှင့်တင်ရန်အတွက် ပြည့်စုံမှုအနည်းဆုံးဖြစ်သည့် နိုင်ငံများအနက်မှ တစ်နိုင်ငံလည်း ဖြစ်သည်။ သဘာဝသယံဇာတများအား စီမံခန့်ခွဲသည့်နည်းဟန်သည် မြန်မာနိုင်ငံ၏ သမိုင်းတလျှောက် အဓိကကျသည့် အခန်းကဏ္ဍမှ အမြဲပါဝင်နေပြီး စီးပွားရေးဖွံ့ဖြိုးတိုးတက်မှုကို ရေရှည်တည်တံ့အောင် မည်သို့စီမံခန့်ခွဲရမည် ဟူသည့်အချက်သည် မြန်မာနိုင်ငံ၏ ဒီမိုကရေစီ အကူးအပြောင်းအတွက် အဓိကကျသော ပုစ္ဆာတစ်ရပ်ဖြစ်သည်။ ဖေဖော်ဝါရီလ အာဏာသိမ်းမှုဖြစ်ပွားပြီးကတည်းက မြန်မာပြည်သူလူထုသည် ဆန္ဒထုတ်ဖော်ခြင်း၊ ‘ပြည်သူ့ကာကွယ်ရေးတပ်မတော်’ နှင့် တိုင်းရင်းသားလက်နက်ကိုင် တော်လှန်ရေးအဖွဲ့အစည်းများက ဦးဆောင်လျက် လက်နက်ကိုင်တော်လှန်ခြင်းတို့ဖြင့် စစ်တပ်ကိုဆန့်ကျင်၍ ဆော်ဩစည်းရုံးမှုများ ပြုလုပ်လျက်ရှိသည်။ ယင်းလှုပ်ရှားဆောင်ရွက်သူအုပ်စုများနှင့် ၎င်းတို့နှင့်ဆက်စပ်နေသော ဖက်ဒရယ်အဆင့် ကြားကာလစီမံအုပ်ချုပ်ရေးအင်စတီကျူးရှင်းများသည် အနာဂတ် ဖက်ဒရယ်ဒီမိုကရက်တစ် ပြည်ထောင်စုမြန်မာနိုင်ငံအတွက် ကြားကာလဖွဲ့စည်းပုံအခြေခံဥပဒေ၊ အမြဲတမ်းဖွဲ့စည်းပုံအခြေခံဥပဒေတို့ကို ညှိနှိုင်းဆောင်ရွက်ရန် နိုင်ငံရေးမူဘောင်တစ်ရပ်ကို ချမှတ်ရေးဆွဲလျက်ရှိသည်။ ဤမူဝါဒစာတမ်းတွင် မြန်မာနိုင်ငံ၏ သဘာဝပတ်ဝန်းကျင်နှင့် ရာသီဥတုဆိုင်ရာစီမံအုပ်ချုပ်မှုအခက်အခဲများ အကြောင်းကို ခြုံငုံသုံးသပ်ထားပါသည်။ ထို့ပြင် အနာဂတ် ဖွဲ့စည်းပုံအခြေခံဥပဒေ မူဘောင်မှ သဘာဝပတ်ဝန်းကျင်အား ထိန်းသိမ်းစောင့်ရှောက်ခြင်း၊ ဇီဝမျိုးစုံမျိုးကွဲများ ထိန်းသိမ်းကာကွယ်ခြင်း၊ တရားမျှတမှုကို ရယူနိုင်စေခြင်း နှင့် ရာသီဥတုပြောင်းလဲမှုအား ဖြေရှင်းခြင်းတို့အတွက် မည်သို့အာမခံချက်ပေးနိုင်ကြောင်းကို နိုင်ငံတကာတွင်ကျင့်သုံးလျက်ရှိသည့် အလေ့အထကောင်းများ၊ ဖြစ်ရပ်နှိုင်းယှဉ်လေ့လာချက်များဖြင့် ထည့်သွင်းစဥ်းစားဖွယ်အချက်များကို တင်ပြထားသည်။ နောက်ဆုံးတွင် မူဝါဒအရ ရွေးချယ်ဆောင်ရွက်နိုင်သည့်အချက်များ နှင့် အကြံပြုချက်များကို ဖော်ပြထားပါသည်။
Dự báo khả năng nứt nhiệt trong bê tông tuổi sớm trong kết cấu trụ cầu sử dụng mạng nơ-ron nhântạo
Authors: Tú Đỗ Anh , Hiếu Nguyễn Minh , Tâm Trần Đức , Hà Ly Nguyễn Thị
Published: December 2022

Trụ cầu là bộ phận kết cấu quan trọng của công trình cầu, đóng vai trò chịu lực và truyền lực từ kết cấu nhịp xuống nền móng, giữ ổn định cho kết cấu nhịp. Trong thực tế xây dựng các công trình cầu bê tông, các bộ phận như móng, mố, trụ có thể xuất hiện vết nứt (bao gồm nứt do nhiệt, nứt do co ngót,...) ngay từ sớm gây ảnh hưởng đến tính nguyên vẹn cũng như khả năng chịu lực và tuổi thọ của công trình. Bên cạnh các phương pháp kinh nghiệm, kỹ sư, hoặc mô phỏng số thì mạng nơ-ron nhân tạo (ANN) cho thấy tiềm năng to lớn trong dự báo rủi ro nứt nhiệt tuổi sớm trong bê tông trụ cầu. Bài báo này trình bày việc sử dụng mô hình ANN để dự đoán khả năng nứt nhiệt tuổi sớm trong bê tông trụ cầu trong điều kiện nhiệt độ môi trường thông thường ở Việt Nam. Các thuật toán Levenberg-Marquardt, Bayesian Regularization và Scaled Conjugate Gradient cùng với bộ dữ liệu bao gồm 462 mẫu được sử dụng để phục vụ cho việc huấn luyện, so sánh và kiểm chứng mô hình. Hiệu suất của mô hình được đánh giá thông qua các tiêu chí thống kê, từ đó đưa ra được thuật toán tốt nhất để sử dụng. Kết quả từ các mô hình huấn luyện cho thấy mạng ANN là công cụ tốt để dự báo rủi ro nứt nhiệt trong bê tông trụ cầu và thời điểm xảy ra tương ứng.
Đánh giá lãng phí trong xây dựng bằng phân tích nhân tố và các mô hình trí tuệ nhân tạo
Authors: Học Trần Đức , Anh Nguyễn Thiện , Long Lương Đức , Thoan Nguyễn Ngọc
Published: December 2022

Các hoạt động phi giá trị gia tăng hay còn gọi là lãng phí gây ra giảm giá trị của dự án nhưng vẫn chưa được quan tâm nhiều trong công tác quản lý xây dựng hiện nay. Nghiên cứu này xác định các yếu tố ảnh gây lãng phí trong thi công xây dựng bằng cách thực hiện bảng câu hỏi khảo sát về tần suất xuất hiện của những nguyên nhân gây lãng phí trong thi công xây dựng. Đối tượng khảo sát là những người có kinh nghiệm xây dựng và quản lý các dự án nhà cao tầng tại Tp. Hồ Chí Minh. Kết quả phân tích nhân tố cho thấy có 8 nhóm chính được trích ra với 75,5% phương sai được giải thích cho tất cả các yếu tố lãng phí trong các dự án xây dựng. Giá trị trung bình của việc tăng chi phí dự án do những lãng phí này là khoảng 8,75% tổng chi phí dự án. Tiếp theo, các thuật toán trí tuệ nhân tạo bao gồm mạng nơ ron nhân tạo (ANN), hồi quy tuyến tính (LR), máy hỗ trợ véc tơ hồi quy (SVR) được sử dụng để ước tính tác động của các yếu tố lãng phí đến chi phí thực hiện dự án. Kết quả phân tích cho thấy sự khác biệt giữa giá trị dự đoán và giá trị thực tế là khá nhỏ và thuật toán hồi quy tuyến tính cho kết quả dự đoán tốt nhất.
Karakteristik Limbah Tailing Sebagai Bahan Baku Mortar Siap Pakai
Authors: Mulia Adhi Yudha , Sari Indriansi Nirwana
Published: December 2022

Pembangunan infrastruktur di Provinsi Papua masih tertinggal, disebabkan oleh mahalnya biaya konstruksi, dengan Indeks Kemahalan Konstruksi (IKK) Provinsi Papua tahun 2016 mencapai 239,98. Salah satu solusi adalah memanfaatkan limbah tailing sebagai bahan bangunan. Penelitian ini bertujuan mendapatkan komposisi mortar siap pakai berbahan baku tailing yang memenuhi persyaratan teknis dan aman bagi lingkungan. Penelitian ini meliputi rangkaian pengujian laboratorium untuk mengetahui komposisi kimia, karakteristik fisik dan gradasi tailing, karakteristik mekanik mortar, serta toksisitas tailing, campuran mortar dan produk mortar (campuran mortar ditambah air). Sampel tailing diambil di antara mile area (MA) 205 dan MA 227 di area pengendapan ModADA. Hasil uji komposisi kimia menunjukkan kandungan SiO2, Fe2O3, dan Al2O3 mencapai 68,8%. Analisis gradasi dan karakteristik fisik juga memenuhi persyaratan sebagai agregat halus. Komposisi mortar untuk plesteran, thinbed bata ringan dan finishing plaster dengan variasi filler kapur dan abu terbang memenuhi persyaratan kuat tekan, kecuali finishing plaster dengan filler abu terbang. Hasil uji TCLP terhadap 3 (tiga) fase tailing memenuhi persyaratan ambang batas untuk limbah B3. Berdasarkan hal tersebut, tailing memenuhi persyaratan teknis dan sebagian persyaratan toksisitas sebagai bahan baku mortar siap pakai. Apabila akan dikomersialisasikan, penulis merekomendasikan untuk dilakukan uji skala produksi, uji toksikologi Lethal Dose-50(LD50), serta analisis bisnis.
Kuat Tekan Dan Pelindian Logam Berat Paving Block dari Limbah Bahan Berbahaya Beracun Pengolahan Logam Terkait dengan Standar Nasional Indonesia
Authors: Sulityowati Nurul Aini
Published: December 2022

Bentuk fisik limbah B3, yang menyerupai agregat dapat digunakan sebagai bahan pengganti agregat dalam pembuatan paving block. Eksperimen pembuatan mortar dengan 5 komposisi campuran dan 2 persentase limbah pengolahan logam. Pembuatan paving block menggunakan komposisi campuran dengan kuat tekan mortar yang tertinggi.  Kuat tekan mortar dan paving block diuji pada umur 28 hari. Pengujian Toxicity Characteristic Leaching Prosedure atau  TCLP dilakukan pada limbah B3 dan paving block.  Analisis kuat tekan dengan membandingkan standar SNI 03-0691-1996 dan analisis TCLP dengan PP no. 101 tahun 2014. Konsentrasi  zat pencemar logam berat yang terlindi dalam paving block limbah pengolahan logam dapat berkurang atau tetap sama dibandingkan dengan limbah pengolahan logam. Untuk keamanan lingkungan dan kesehatan manusia diperlukan usulan penambahan persyaratan konsentrasi zat pencemar yang terlindi dalam standar paving block atau membuat standar baru mengenai proses penggunaan limbah B3 untuk paving block.
Pemeriksaan Mutu Beton Terpasang Menggunakan Pengujian Nondestruktif (NDT) dan Destruktif, Studi Kasus: Bangunan Beton Bertulang 4 Lantai
Authors: Pratama Egi , Kadir Yushar , Siregar Chandra Afriade , Gumilang S. Angga Arief
Published: December 2022

Pemeriksaan mutu beton terpasang dapat dilakukan dengan menggunakan metode destruktif maupun nondestruktif. Pengujian destruktif mutu beton terpasang yang umum dilakukan adalah pengambilan sampel core drill. Sementara itu pengujian nondestruktif dapat dilakukan dengan beberapa metode seperti hammer test, UPV test, pull out test, dll. Namun demikian pengujian nondestruktif tidak dapat langsung digunakan untuk mengkuantifikasi kuat tekan beton terpasang dilakukan pengkorelasian data secara valid. Dalam penelitian ini dilakukan pemeriksaan mutu beton terpasang dengan menggunakan pengujian destruktif yaitu pengambilan sampel core serta pengujian nondestruktif menggunakan hammer test. Studi kasus dilakukan pada bangunan objek kajian berupa bangunan dengan struktur rangka beton bertulang 4 lantai yang dibangun pada tahun 1987. Jumlah sampel hammer test yang diambil adalah sebanyak 32 buah, dimana 13 diantaranya dilengkapi dengan pengambilan sampel core. Dari 13 data irisan sampel core dan hammer test tersebut dilakukan penyusunan kurva strength relationship yang merupakan hubungan korelasi antara nilai Rebound hammer test terhadap kuat tekan beton. Dari persamaan korelasi yang diperoleh selanjutnya dapat dilakukan pengkonversian seluruh data nilai Rebound hasil hammer test terhadap kuat tekan beton terpasang sehingga jumlah sampel pengujian pada bangunan objek kajian menjadi lebih banyak jika dibandingkan dengan hanya menggunakan sampel core saja. Hasil analisis dan interpretasi terhadap data hasil pengujian menunjukkan bahwa nilai rata-rata kuat tekan beton ekivalen terpasang pada bangunan objek kajian adalah sebesar (f_c ) ̅=12.21 MPa, dengan nilai kuat tekan pada 10-persentil fractile yang dihitung menggunakan Tolerance factor method (Hindo dan Bergstorm, 1985) dan Alternate method (Bartlett dan MacGregor, 1995) berturut-turut adalah f_(c,eq.1)^'=5.37 MPa dan f_(c,eq.2)^'=8.87 MPa.
Instalasi Pengolahan Air (IPA) Mobile Solusi Pemenuhan Kebutuhan Air pada Tahap Tanggap Bencana
Authors: Ashuri Amallia
Published: December 2022

Air merupakan kebutuhan utama manusia, begitu pula untuk masyarakat terdampak bencana. Mereka harus bisa menjangkau ketersediaan air bersih yang memadai untuk memelihara kesehatannya. Pada tahap awal kejadian bencana, ketersediaan air bersih bagi pengungsi perlu mendapat perhatian karena tanpa air bersih pengungsi akan rentan tertular penyakit seperti diare, tifus, scabies, dan penyakit lainnya. Salah satu solusi untuk mengatasi permasalahan penyediaan air minum di daerah bencana adalah dengan menyediakan air melalui unit Instalasi Pengolahan Air (IPA) dengan sistem mobile. IPA mobile dalam kegiatan ini didesain dengan tetap mempertimbangkan pemenuhan kebutuhan air bagi masyarakat yang memenuhi persyaratan kuantitas, kualitas, dan kontinuitas. Aspek kuantitas dievaluasi dengan pengukuran kapasitas operasi selama uji kinerja IPA mobile. Aspek kualitas dievaluasi dengan perbandingan kualitas air olahan dengan baku mutu air minum Permenkes No. 492/MENKES/PER/IV/2010. Sementara aspek kontinuitas dievaluasi dengan kemampuan IPA beroperasi selama 12 jam. Berdasarkan hasil uji kinerja, IPA mobile telah mampu memenuhi ketiga aspek tersebut. Catatan penting yang didapat selama uji kinerja adalah operasional IPA mobile harus diperhatikan agar kinerja IPA mobile terutama dalam pemenuhan aspek kualitas dapat terjaga.
Sing Liveworksheets web service for creating and checking math homework
Authors: Zinchenko I.V. , Turka T.V.
Published: December 2022

This article explores possibilities of using internet resources by mathematics teachers in educational process. The concept of a constructor of interactive spreadsheets and the essence of their work is revealed. An analysis of the LiveWorkSheets web service, when used in the educational process, was revealed. The advantages of this platform are highlighted, and an example of math homework is given.
Quality evaluation of “Kangu” produced from bambara nut (Vigna subterranean) and yellow maize (Zea mays) composite flour
Authors: Oluwafemi Ayodeji Amos , Abiodun Adekunle Olapade , Oluwayemisi Foluke Awofadeju
Published: December 2022

Legumes play a very important nutritional role in the diet of millions of the populace around the world as major sources of protein and minerals (FAO, 2016). In developed countries, plant proteins are now considered as important component than major nutrients. The aim of this study is to produce ‘kangu’ from bambara nut and maize composite flour. This study examined the chemical properties of ‘Kangu,’ a value added snack produced using composite flour of Bambara groundnut and maize. Four composite flours were prepared by homogenously mixing Bambara flour and maize flour in the proportions of 90:10, 80:20, 70:30, and 60:40 and evaluated for functional properties and chemical composition. Valueadded snacks produced were evaluated for colour properties, water absorption ability and sensory acceptability using 100% Bambara flour as a control. The loose bulk density, packed bulk density, dispersibility, water and oil absorption of the composite flour increased when compared with 100% Bambara flour. At 70°C, 80°C and 90°C, the swelling power of composite flour was nearly the same, with only a little differential at 50°C, and 60°C. The moisture content, ash, fat and crude fibre of the composite flours significantly increased when compared to 100% Bambara flour with the exception of protein and carbohydrate. Sensory evaluation by semi-trained panelist indicated consumer acceptability. However, the sample that contained 60% Bambara flour and 40% maize flour scored the highest for crunchiness, taste and overall acceptability, while 100% Bambara flour scored the highest for appearance and colour. Composite flour with 30% maize substitution absorbed the highest moisture (0.76 g) among other stored snacks. Maize is rich in the amino acid methionine and deficient in lysine which is readily available in bambara groundnut, where as methionine is limited in bambara nut, this suggested that products from bambara and maize flour should be encourage so as to solve the problem of malnutrition
Biljni proteinski hidrolizati kao dodatak medijima za uzgoj životinjskih stanica
Authors: Gaurina Srček Višnja , Ursić Tino , Logarušić Marijan , Radošević Kristina , Slivac Igor
Published: December 2022

U procesima s kulturama životinjskih stanica koristi se medij za uzgoj koji sadrži osnovne nutrijente poput glukoze, amino-kiselina, soli te hormone i faktore rasta iz seruma životinjskog porijekla. Zbog nedostataka primjene seruma u procesima s kulturama stanica (npr. rizik prijenosa virusa, varijacije u sastavu, otežana izolacija proizvoda) pristupilo se razvoju medija bez seruma u koje se često dodaju i hidrolizati proteina biljnog porijekla. Hidrolizati sadrže aminokiseline, oligopeptide, lipide, vitamine i ostale spojeve koji potiču proliferaciju i produktivnost stanica u kulturi. U ovom radu dan je kratak pregled priprave i najvažnijih bioloških svojstava proteinskih hidrolizata s naglaskom na primjenu biljnih hidrolizata kao sastojaka medija za uzgoj životinjskih stanica u proizvodnji biofarmaceutika.
Reproduction of reservoir pressure by machine learning methods and study of its influence on the cracks formation process in hydraulic fracturing
Authors: Filippov Еvgenii , Zakharov Lev , Martyushev Dmitrii , Ponomareva Inna
Published: December 2022

Hydraulic fracturing is an effective way to stimulate oil production, which is currently widely used in various conditions, including complex carbonate reservoirs. In the conditions of the considered field, hydraulic fracturing leads to a significant differentiation of technological efficiency indicators, which makes it expedient to study in detail the crack formation patterns. For all affected wells, the assessment of the resulting fractures spatial orientation was performed using the developed indirect technique, the reliability of which was confirmed by geophysical methods. In the course of the analysis, it was found that in all cases the fracture is oriented in the direction of the development system element area, which is characterized by the maximum reservoir pressure. At the same time, reservoir pressure values for all wells were determined at one point in time (at the beginning of hydraulic fracturing) using machine learning methods. The reliability of the used machine learning methods is confirmed by high convergence with the actual (historical) reservoir pressures obtained during hydrodynamic studies of wells. The obtained conclusion about the influence of the formation pressure on the patterns of fracturing should be taken into account when planning hydraulic fracturing in the considered conditions.
Study on the rheological properties of barite-free drilling mud with high density
Authors: Leusheva Ekaterina , Alikhanov Nazim , Brovkina Nataliia
Published: December 2022

Improved drilling and reservoir penetration efficiency is directly related to the quality of the drilling mud used. The right choice of mud type and its components will preserve formation productivity, stability of the well walls and reduce the probability of other complications. Oil and gas operators use barite, less often siderite or hematite weighting agent as a weighting component in the composition of drilling muds for the conditions of increased pressure. But the use of these additives for the penetration of the productive formation leads to the reduction of filtration characteristics of the reservoir, as it is almost impossible to remove them from the pore channels. Therefore, barite-free drilling mud of increased density based on formic acid salts with the addition of carbonate weighting agent as an acid-soluble bridging agent is proposed. The results of experimental investigations on rheological parameters of barite-free solutions are given and the obtained data are analyzed. Based on the comparison of results it is recommended to use high-density drilling mud on the basis of formic acid salts (sodium and potassium formate) and with the addition of partially hydrolyzed polyacrylamide with molecular mass of 27 million.
How Lecturers, Supervisors, and MGMP PAI Collaborate in Sustainable Professional Development (PKB): an Observation in Sleman Regency
Authors: Sabarudin Sabarudin , Mubin Muhammad Nurul , Arifin Zaenal , Maulida Wahidatun , Asror Ahmad Maulana
Published: December 2022

This research aims to illustrate the collaboration of lecturers, students, supervisors, and MGMP in the development of sustainable professional teachers in Sleman Regency. This research uses a qualitative approach with descriptive research types of cooperation among lecturers, students, supervisors, and MGMP in the development of sustainable professional pai teachers in Sleman Regency. Data collection is done through telephone interviews and/or cloud meeting zooms. As well as spreading the questionnaire, it was done using a Google form given to MGMP members through WhatsApp messages. The results showed the importance of collaborating with teachers and supervisors who feel the need for help and competent speakers and lecturers who have funds and expertise for service and develop the quality of education in the local region of their universities. The form of collaboration is the training of PTK, LKPD, and Canva Learning Media Development. The busy schedules of many MP members, limited funds, and poor communication between supervisors, MGMP, and universities are all barriers to collaboration. The supporting factors are the existence of new regulations that encourage the development of kopetensi, the creativity of MGMP supervisors in establishing communication with universities, the allocation of funding from universities, and alumni networks as information distributors or liaisons. This research is expected to provide an overview and a theory about the form of cooperation between lecturers, students, supervisors, and MGMP.
Development of Mind Mapping Based Prezi Multimedia to Improve History Learning Outcomes
Authors: Agustina Renita , Sudrajat Ajat , Setiawan Johan , Sudarwati Ninik
Published: December 2022

The purpose of the study was to develop, test the feasibility, and test the effectiveness of Mind Mapping-based Multimedia Prezi Next Online on Hindu-Buddhist history materials in Indonesia for students of history education at Yogyakarta State University. This research is a Research and Development, 4D model (Define, Design, Develop, Disseminate). Data collection techniques consisted of interviews, questionnaires, and tests. Data analysis techniques are in the form of preliminary studies and product feasibility. Product effectiveness analysis test for normality, homogeneity, and effectiveness. The results of the research are: (1) Developing a Multimedia Prezi Next Online product based on Mind Mapping for learning the history of materials from the Sriwijaya Kingdom. (2) The results of the feasibility of the material get 48 points and are in the appropriate category. The media aspect was assessed by media experts to get an overall score of 68, which is in the very decent category. (3) The results of the effectiveness of N-Gain describe the effectiveness of developing Mind Mapping-based Prezi Next Online with materials from the Sriwijaya Kingdom, this is indicated by an increase in learning outcomes in the classroom using Mind Mapping-based Prezi Next Online Multimedia. The use of Multimedia Prezi can deliver more interesting material and the learning process will be more fun and easy to understand.
Development of Hots-Based E-Worksheets for Arabic Grammar Course in Department of Arabic Language Education
Authors: Kamaluddin Kamaluddin , Husna Lathifah Al , Nurlaila Nurlaila , Amelia Amelia , Musthafa Izzuddin , Elwarfali Suliman Hassan Suliman
Published: December 2022

The purpose of this research is to produce a valid and practical Arabic grammar e-worksheet for university students based on Higher Order Thinking Skills (HOTS). The research type is Research & Development (R&D) with the Instructional Development Institute (IDI) model. Research data were collected through questionnaires and documentation. The data obtained from the validity and practicality questionnaires were tabulated for each component of the assessment and then the average score was calculated and converted into qualitative data. Documentation technique is done by analyzing documents in the form of syllabus, materials, and literatures. The results of this research and development show that the developed Arabic grammar e-worksheet is stated to be very valid with an average validity score of 4.35 and very practical with an average practicality score of 4.8. Based on the results, it is hoped that the lecturers will be able to use the developed e-worksheet in the Arabic grammar course, because it can facilitate students' higher-level thinking skills.
The Amyloid Cascade Hypothesis 2.0: Generalization of the Concept
Authors: Volloch Vladimir , Rits-Volloch Sophia
Published: December 2022

Recently, we proposed the Amyloid Cascade Hypothesis 2.0 (ACH2.0), a reformulation of the ACH. In the former, in contrast to the latter, Alzheimer’s disease (AD) is driven by intraneuronal amyloid-β ( iAβ) and occurs in two stages. In the first, relatively benign stage, Aβ protein precursor (AβPP)-derived iAβ activates, upon reaching a critical threshold, the AβPP-independent iAβ-generating pathway, triggering a devastating second stage resulting in neuronal death. While the ACH2.0 remains aligned with the ACH premise that Aβ is toxic, the toxicity is exerted because of intra- rather than extracellular Aβ. In this framework, a once-in-a-lifetime-only iAβ depletion treatment via transient activation of BACE1 and/or BACE2 (exploiting their Aβ-cleaving activities) or by any means appears to be the best therapeutic strategy for AD. Whereas the notion of differentially derived iAβ being the principal moving force at both AD stages is both plausible and elegant, a possibility remains that the second AD stage is enabled by an AβPP-derived iAβ-activated self-sustaining mechanism producing a yet undefined deleterious “substance X” ( sX) which anchors the second AD stage. The present study generalizes the ACH2.0 by incorporating this possibility and shows that, in this scenario, the iAβ depletion therapy may be ineffective at symptomatic AD stages but fully retains its preventive potential for both AD and the aging-associated cognitive decline, which is defined in the ACH2.0 framework as the extended first stage of AD.
Evaluation of breast cancer metastasis and mortality rates based on molecular subtype: A description study
Authors: Kurniawan Benny Nanda , Ferianto Djonny , Pieter Jr John
Published: December 2022

BACKGROUND: Breast cancer in Indonesia has continued to increase. One diagnostic modality is immunohistochemical examination to determine breast cancer subtypes. OBJECTIVE: To determine breast cancer metastasis and mortality rates based on molecular subtypes. METHODS: A descriptive study was conducted based on retrospective data from hospital medical records from January 2016 to December 2019. The data comprised age, clinical stage, histopathological grade, molecular subtype, location, metastasis, and breast cancer mortality. The data were processed and analyzed. RESULTS: This study involved 172 patients. The most prevalent breast cancer subtypes were luminal A (60, 34.8%), followed by HER2 (47, 27.4%), triple-negative (38, 22.4%), and luminal B (27, 15.4%). The metastasis rate was 37.21% (64/172), with bone the tissue most affected (32 cases, 50%), followed by lung (24 cases, 37.5%) and liver (8 cases, 12.5%). The highest rates of bone, lung, and liver metastases were subtypes luminal A (31%), HER2 (29%), and triple-negative (38%), respectively. The mortality rate was 21% (36/172), with most in the triple-negative group (28.9%), followed by luminal B (25.9%), HER2 (21.2%), and luminal A (13.3%). CONCLUSIONS: Determination of breast cancer molecular subtypes through immunohistochemistry can determine the level of metastasis and mortality in breast cancer.
A new AC motor driven by travelling magnetic field excited on LC ladder circuit without its nonlinearity
Authors: Kato Masayuki , Hirata Katsuhiro
Published: December 2022

In three-phase AC motors, three-phase AC voltage system is essential to generate a rotating magnetic field. Three- phase AC motors also require a three-phase inverter for variable speed and torque operation. In general, the number of switching devices used in three-phase inverter is not less than six and decreasing its number is difficult. This paper focuses on an LC ladder circuit consisting of linear inductors and capacitors. This paper presents a new operating method of the AC motor based on a propagating magnetic field. It is successfully excited by connecting one single-phase AC power supply to the end of the LC ladder circuit. The induction motor operated by the presented method produces torque as in general induction motors.
Extraction of weak signal based on wire rope detection in timing belt of wind turbines
Authors: Liu Mengqi , Zhang Chi , Sun Yanhua , Jiang Xiaoyuan , He Lingsong
Published: December 2022

As promising non-destructive testing (NDT) method, magnetic flux leakage (MFL) testing has been widely applied for steel structure detection. However, magnetic flux leakage (MFL) signal collected by the sensors is weak, especially for the small diameter wire rope. The methods of using the traditional circular coil sensors, or increasing the number of magnets is ineffective in some situations. This study proposes a new method of highly sensitive long-strip-shape coil sensors with an analogue signal processing circuit used to detect wire rope in the timing belt of wind turbines. It is investigated by theory analysis, circuit simulation, and experiment conduction. The circuit is used to amplify the weak signal and filter high-frequency noise to obtain a high signal-to-noise ratio (SNR). Experiments show that the resolution of the method can reach 3 broken wires of 0.1 mm wire diameter, and the method can not only obtain a high SNR signal but also have good repeatability. Meanwhile, this method will have great significance in practical applications and provide some solutions for other similar NDT projects.
Effect of steering reaction torque of ultra-compact electric vehicle on steering burden for active steering wheel system
Authors: Uchino Daigo , Hira Takamasa , Ogawa Kazuki , Ikeda Keigo , Kato Taro , Endo Ayato , Kato Hideaki , Narita Takayoshi
Published: December 2022

An ultra-compact electric mobility vehicle cannot be equipped with power steering, and the physical burden is large. Therefore, we are continuously researching steering support for an ultra-compact electric mobility vehicle equipped with a steer-by-wire system (SBWS). The SBWS has not been widely diffused because the steering and front wheels are connected only to electric signals and do not have a high redundancy level. However, the advantage of an SBWS is that the steering reaction torque felt through the steering wheel can be controlled freely. We investigated an active steering wheel system (ASWS) that can control an appropriate steering feeling for each driver by being equipped with SBWS and evaluating the steering burden of each driver. So far, research on the SBWS has been considered to improve operability by transmitting road information and feeding back vehicle motion, however few research on an SBWS considers the physical and mental burden on the driver. In this study, we conducted a fundamental analysis of the effect of the steering reaction torque on the steering burden, focusing on the operating direction of the steering wheel.
Nonlinear adaptive tracking control of piezoelectric bimorph actuator using hybrid modeling approach
Authors: Chen Yuansheng , Chen Yuhang , Zheng Lei , Tong Lichen , Chen Wei , Ji Hongli
Published: December 2022

Piezoelectric bimorph actuator has the advantages of small size, fast response speed and high displacement accuracy, but its inherent hysteresis nonlinearity seriously affect the control accuracy and stability of the system. The dead-zone operator was incorporated into classical Prandtl–Ishlinskii model to enable the description of asymmetric hysteresis of piezoelectric bimorph actuator. A hybrid model approach was developed with neural network and improved Prandtl–Ishlinskii model, and it has the advantages of a neural network with ready-made training algorithms and improve the Prandtl–Ishlinskii (PI) model to describe the asymmetric hysteresis. The adaptive control method was derived from training algorithm of neural network, which can update the weight parameters of Play operator and Dead-zone operator in real time. Comparing the results without control, the RMSE of displacement error decreases by 61.35% with classic model, and decreases by 82.93% with hybrid model and proposed adaptive tracking control. Experimental results show that the proposed hybrid model and adaptive control approach can more effectively compensate the hysteresis of piezoelectric bimorph.
Design and analysis of in-wheel motor with sinusoidal permanent magnet shape for electrical vehicles
Authors: Wang Ning , Zhao Wenliang , Li Min , An Ningning
Published: December 2022

This paper deals with the design and analysis of a surface-mounted outer rotor in-wheel motor (IWM) with the aim of reducing cogging torque and torque ripple for electric vehicles. The proposed IWM is equipped with axial sinusoidal surface-mounted permanent magnets (PMs), with the purpose of producing sinusoidal air gap flux density distribution, thus to realize sinusoidal back electromotive force (EMF) and smooth electromagnetic torque. To highlight the advantage of the proposed IWM, the conventional IWM with tile-shaped PMs and the IWM with stepwise-shaped PMs are also studied for comparison. The finite element method in the commercial software package is utilized to analyze the performance of the three motors, including the radial flux density of air gap, back EMF, cogging torque, and electromagnetic torque. Through the quantitative comparison, it is found that the proposed IWM greatly reduces the cogging torque, highly improves the sinusoidality of back EMF, and nearly eliminates the torque ripple.
A three-way decision model on incomplete single-valued neutrosophic information tables
Authors: Yang Hai-Long , Ren Huan-Huan
Published: December 2022

In this paper, we focus on the three-way decision model on incomplete single-valued neutrosophic information tables. Firstly, we define the minimum and maximum similarity measures between single-valued neutrosophic numbers (SVNNs) which may contain unknown values. On this basis, the notion of θ-weak similarity measure is given. Then, we introduce the conception of an incomplete single-valued neutrosophic information table (ISVNIT). For an incomplete single-valued neutrosophic information table, a new similarity relation is proposed based on the θ-weak similarity measure. Some properties are also studied. By using Bayesian decision theory and this similarity relation, we construct a three-way decision model on an ISVNIT. Finally, an example of choosing product service providers is explored to illustrate the rationality and feasibility of the proposed model. We also discuss the influence of parameters in the model on decision results.
Uncertain DEA-Malmquist productivity index model and its application
Authors: Wu Jiali , Sheng Yuhong
Published: December 2022

Uncertain data envelopment analysis (DEA) model make an estimate of the efficiency of decision making unit (DMU) under data uncertainty. The current research on uncertain DEA model is only based on sectional data to calculate DMU’s static efficiency for the DMU’s set in the same period. From this article, we attempt to combine Malmquist productivity index and uncertain DEA model (the uncertain DEA-Malmquist productivity index model) to calculate the dynamic change of DMU’s efficiency over time. Additionally, the impact of technical factors and scale factors on DMU’s efficiency can be further explored and the Malmquist productivity index will be decomposed into pure technical efficiency change, scale efficiency change and technical change. Finally, the article uses the model to analyze the provincial environmental efficiency from 2014 to 2016 in China.
Test case prioritization for changed code using nature inspired optimizer
Authors: Pathik Babita , Pathik Nikhlesh , Sharma Meena
Published: December 2022

The software development and maintenance phase succeeded with significant regression testing activity. The software must be re-tested every time it upgrades to preserve its quality. Software testing as a whole is an expensive and tedious task due to resource constraints. Using the prioritization technique implies regression testing to re-test software after it has been modified. In this situation, the prioritization technique can use information acquired about earlier test case executions to generate test case orderings. The approaches for test case prioritization arrange them all in such a sequence that maximizes their efficacy in accomplishing specific goals. This paper presents a hybrid technique for change-testing or regression testing through test case prioritization. The suggested method first generates the test cases, then clustered in untested and unimportant groups using kernel-based fuzzy c-means clustering technique. The appropriate test cases are then considered for prioritization using the grey wolf optimizer. The results compared with the approaches such as ant colony, particle swarm, and genetic algorithm optimization method, and it is observed that the proposed approach efficiency increased by 91% of fault detection rate.
PDQ-8: A Simplified and Effective Tool Measuring Life Quality in Progressive Supranuclear Palsy
Authors: Li Xin-Yi , Chen Ming-Jia , Liang Xiao-Niu , Yao Rui-Xin , Shen Bo , Wu Bin , Li Gen , Sun Yi-Min , Wu Jian-Jun , Liu Feng-Tao , Yang Yu-Jie , Wang Jian ,   for the Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI)
Published: December 2022

Background:

The self-reported quality of life (QoL) should be carefully listened to in progressive supranuclear palsy (PSP) from the patient-centered perspective. However, there was still a lack of short QoL measurement tool in atypical parkinsonism.

Objective:

We aimed to test whether the short Parkinson’s Disease Questionnaire-8 (PDQ-8) was effective in assessing QoL in PSP, comparing with Progressive Supranuclear Palsy Quality of Life Scale (PSP-QoL) and Parkinson’s Disease Questionnaire-39 (PDQ-39).

Methods:

132 patients with clinical diagnosed PSP, including PSP-Richardson syndrome (RS) subtype ( n = 71) and PSP-non-RS subtype ( n = 61) were recruited for clinical evaluation including QoL assessment. The detailed QoL profiles and possibility of using PDQ-8 were systemically analyzed. The determinants to the QoL were then calculated by multivariate linear regression analysis.

Results:

The PSP-QoL total score summary index (SI) was 22.8 (10.1, 41.1), while the PDQ-8 and PDQ-39 total SI score were 28.1 (12.5, 46.9) and 29.5 (15.4, 49.4). Mobility, activities of daily life, cognition and communication were the main affected QoL subdomains (median SI: 40.0, 31.3, 25.0 and 25.0 respectively). PSP-RS subtype showed more severe damage physically ( p<0.001) and mentally ( p = 0.002) compared to other subtypes. More importantly, the strong relevance of PDQ-8 and recommended PSP QoL tools were confirmed ( p<0.001). In addition, disease severity, depression and daytime sleepiness were proved to be critical determinants for QoL in PSP.

Conclusions:

PDQ-8 could be an easy, reliable, and valid tool to evaluate QoL in patients with PSP. Besides motor symptoms, more attention should be paid to non-motor impairment such as depression in PSP.
Validity and reliability of five-times-sit-to-stand test with a dual task in older adults with mild cognitive impairment
Authors: Chimsuwan Perayut , Chanabangkaew Kanyakon , Aniwattanapong Daruj , Suriyaamarit Duangporn
Published: December 2022

INTRODUCTION: Although the five-times-sit-to-stand test (FTSST) is commonly used to analyse functional capacity, in older adults with mild cognitive impairment (MCI), many activities of daily living, such as walking while holding objects, require the simultaneous performance of motor and motor tasks. Hence, the FTSST with a secondary task has been introduced, though there is a lack of evidence on its validity and reliability. This study aimed to examine the concurrent validity and reliability of the FTSST with a dual task in older adults with MCI. METHODS: Twenty-eight older adults with MCI participated in the study. All participants performed the FTSST, FTSST with a dual task and Timed Up and Go (TUG) test. The concurrent validity of the FTSST with a dual task was established with the TUG. RESULTS: Moderate concurrent validity was found between the FTSST with a dual task and the TUG, with Pearson’s r = 0.59 (p < 0.001). The FTSST with a dual task exhibited good intra-rater (ICC 3,2 = 0.99) and inter-rater (ICC 2,2 = 0.99) reliability. The standard error of measurement and minimal detectable change of the intra- and inter-rater reliability of the FTSST with a dual task were 0.22 and 0.18, respectively. CONCLUSION: This study showed a significant correlation between the FTSST both with and without a dual task and the TUG as well as good inter- and intra-rater reliability when used in older adults with MCI. These findings support using these tests as outcome measures in older adults with MCI.