bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Dimensional Accuracy of Cast Obtained from Polyvinyl Siloxane Impression with Different Putty-Wash Techniques and Spacer Thickness - In Vitro Study
Authors: Pandey Anisha , Mathema S.R.B. , Maharjan S.K.
Published: April 2019

Introduction: Dimensional accuracy of cast obtained after making impressions is crucial factor for the quality of fixed prosthodontic treatment. The impression technique with different thickness of putty wash material is critical factor affecting this accuracy. There is much discussion in the dental literature concerning the effect of this impression technique on the accuracy of cast restorations.

Materials and methods: This in-vitro study was carried out in 60 impression made from master model with Polyvinyl siloxane impressions material using single step putty- wash technique and two step putty-wash technique with varying spacer thickness (0.5mm, 1mm, 1.5 mm). It was further divided into four groups. Group I: Single step putty-wash impression technique, Group II: Two step putty-wash impression technique with 0.5mm spacer, Group III: Two step putty-wash impression technique with 1mm spacer, Group IV: Two step putty-wash impression technique with 1.5mm spacer. Each group consists of 15 impressions. Casts were poured using type IV dental stone after 1 hour. After 24 hour the die of each cast was scanned using CAD/CAM digital scanner and measured mesiodistally, facio-lingually, height (cervico-occlusally), interabutment or interdie distances. The data were recorded and statically analyzed.

Results: The highest mean values of mesio-distal, bucco-lingual, cervico-occlusal distances were shown by Group I, whereas the inter-die distance showed equal mean value in Group I, II and III. With the increase in the spacer thickness, the mean value also increases in mesio-distal distance. The mean measurement of bucco-lingual dimension was highest when spacer thickness was 0.5mm and it declined with the increase in spacer thickness. The spacer thickness had no effect on cervico-occlusal and inter-die dimensions.

Conclusions: Within the limitations of the study, accuracy of cast obtained from single step putty-wash technique was more accurate than two step putty-wash technique. In two step putty-wash technique, 1.5 mm thickness of spacer showed more accurate cast in comparison to 0.5mm and 1mm.
A Simplified Impression Technique for a Flabby Maxilla - A Clinical Report
Authors: Maskey Brijesh , Mathema S.R.B. , Bhochhibhoya A.
Published: April 2019

Flabby maxillary ridge is the most commonly encountered clinical condition during routine dental practice. The presence of these displaceable denture-bearing tissues often poses difficulty during fabrication of complete dentures resulting in compromised support, retention and stability. Many impression techniques and materials have been proposed in various literatures to help overcome this difficulty. These techniques vary in philosophies but are often quite time-consuming to perform, and rely on materials not commonly in use in contemporary dental practice. The purpose of this paper is to describe an impression technique for flabby ridges, using conventional impression material.
Psycholinvistic Potential Neurogenesis (justification of the application of psycholinguistic techniques for the self-improvement of the mechanisms of the Human consciousness using the idea of neurogenesis)
Authors: Krutov Vasyl
Published: April 2019

The purpose of the study is to justify the use of psycholinguistic techniques for self-improvement mechanisms of human consciousness using the idea of neurogenesis. The research method consisted in the following procedures: 1) a detailed study of the history of the problem of the formation of the targeted use of psycholinguistic techniques that can become a tool for expanding the human Consciousness; 2) the expression of constructive criticism of the materialistic theoretical postulates; 3) the formulation (on the basis of criticism, which was discussed in paragraph 2)) of the tasks and prospects for the formation of a Self-Improving Person's Consciousness based on the use of psycholinguistic techniques. Results. In accordance with the first research procedure, the author analyzed the works of predecessors (P. Brock, N. Doydzha, C. Wernicke, S. Volinski, F. Gall, A. Luria, P. Bach-i-Rita, D. Plaut, R. Wilson, D. Hebba, B. Arrowsmouth Young), which used psycho-linguistic techniques aimed at the expansion of human consciousness. Within the framework of the second research procedure, the results of the experiments of the above-mentioned authors expressed constructive criticism of the materialistic approach to explaining the use of psycholinguistic methods as one of the optimal means of human self-improvement. Based on the implementation of the third procedure, the author drew attention to a number of trends (approaches) in the implementation of psycholinguistic techniques, which have a wide potential in the use of the ideas of neurogenesis. Findings. The author justified the use of psycholinguistic techniques for self-improvement mechanisms of human consciousness using the idea of neurogenesis. In addition to the above, the author has thoroughly studied the history of the problem of forming a targeted use of psycholinguistic techniques that can become a tool for expanding human Consciousness. Constructive criticisms of materialistic and idealistic theoretical tenets are made, and on the basis of criticism, the tasks and perspectives of forming the Consciousness of a self-improving person with the help of psycholinguistic techniques that take into account modern advances in neurogenesis are formulated.
Psychosemantic Reconstruction of Health Concepts in Patients with Somatogenia
Authors: Maksymenko Ksenia , Kudermina Olena
Published: April 2019

The article presents the results of study of the subjective psychosemantic space of patients suffering from somatogeny. The construction of a subjective semantic space is fundamentally different from the descriptive researches because it involves an experiment that simulates the certain aspects of linguistic or cognitive activity and allows the reconstruction of the system of values. This is a study of the psychosemantic structure of those semantic structures of consciousness that create a typical conceptual system of self-regulation, forming a normative and actual subjective picture of the own ideas about the health and psychological causes of its violation.
On the example of patients with chronic gastroenterological and cardiovascular diseases, the author used the method of semantic differential by Ch. Ozgud with the subsequent factorization of data and has established the basic psycho-semantic parameters of such patients’ consciousness, which allows to understand how people with a certain structure of consciousness fall into the number of patients suffering from psychogeny . The semantic differential method allows us to evaluate the subjective aspect of the meanings associated with content, social settings, stereotypes and other emotionally loaded, structured, and not enough apperceived forms of generalization. The study was conducted in three stages. At the first one was used the adoption of associations. At the second stage was obtained an array of data that represented the result of applying the semantic differential method to the description of the specified categories. The third stage was aimed at working out the received factual data.
Through the study, there were obtained the results as three factors. The main factor was called “Score”. The second (partial) bipolar factor absorbed three scales and received the name – antonym to the classical scale of Ch. Osgood “Weakness”. The third (partial) unipolar factor also contains three scales. It received the name “Activity”.
The study revealed a number of common features that characterize the partial psychosemantic space of such patients. It was found that the psychosemantic parameters of the psychosemantic space of patients differ by its cognitively-emotional simplicity, low dimensionality, inconsistency and predominance in negative connotations.
The psychosemantic structure of consciousness of the patients suffering from psychogeny involves the special efforts of clinical psychologists and psychotherapists in providing targeted psychological support and assistance to such people.
Psychosemantic Features of Professional Consciousness of Engineers
Authors: Drobot Olha
Published: April 2019

This article presents results of an empiric study of psychosemantic features of professional consciousness of engineers: the associative structure of key professional notions has been determined, and its key properties have been revealed. The method of free associations has been applied; J. Sax’s and S. Levis’s Unfinished Sentences projective technique; original questionnaire. It was proved that engineers are distinguishable for the desire to get promoted to a higher position while retaining inclination toward the present area of activity; functional autonomy; dependence on organization; internal control locus in the situation of professional problems; long-term professional planning; orientation toward refraining from inflicting damages upon others and themselves; balanced moral principles. An associative experiment has been held with stimuli words that concern professional sphere and with words unrelated to the profession. 1524 reactions to 37 stimuli words have been received in total. Building associative complexes for every stimulating notion allowed to reflect contemporary perceptions of respondents about each of them. The following most frequently occurring associations to the “work” stimulus have been highlighted: knowledge, experience, skills, work routine, Monday-Friday, boss, half-life, prospects, growth, success, hard. One of the features of professional consciousness of engineers is fixation of own subordination in performance of professional duties; inclination toward timely accomplishment of simple professional tasks; orientation of mindset toward integrity and discipline in business communication.
Psycholinguistic Study of Functioning of Cognitions and Metacognitions on the Levels of Social Intelligence
Authors: Ivashkevych Eduard , Yatsjuryk Alla
Published: April 2019

The article states that social intelligence in psychology is seen as the ability of a person to understand correctly his/her own behavior and the behavior of other people in the society. This ability is very necessary for a person to have an effective interpersonal interaction and successful social adaptation. Social intelligence implements the functioning of cognitive processes associated with the reflection of a person as a partner in the processes of communication and activities. The main function of social intelligence is to predict the behavior of others.

The authors of the article consider the concept of “intelligence” in the broad and narrow senses. In a broad meaning of “intelligence” it is only one intelligence, the intellectual sphere of the person in general. In this sense, the intelligence of a person can be described as a hierarchical system that has several levels. The first level is the level of functioning of cognitions. The second level of intelligence is the level of metacognitions. The third level of intelligence amplifies the characteristics of both the first and the second levels, while intellectual activity is carried out mainly at an unconscious level, a level that approximates a person to use of automated skills and abilities. The next, the fourth level, is the level of meta-intellectual activity, which explodes the creative achievements of the person.

It was proved that each type of intelligence contained some abilities of the person to perform a certain type of the activity. Guided by the narrow sense of understanding the word “intelligence”, it was determined: social intelligence; technical intelligence; artistic intelligence; information intelligence.

It was described the empirical research which was organized in different regions of Ukraine (the participants of this research were teachers and directors from preschool educational establishments). The results having been received in this research proved that the respondents of all groups have the results which show the advantage of average indicators of their ability to understand the meanings of non-verbal expressions and the meaning of the expression, depending on a social context. This may be due to the fact that these abilities are formed in the immediate process of communication and to a large extent depend on the conditions of the life of the subjects, at the first place – on the conditions of their professional activity, means and methods of professional activity of teachers of preschool educational establishments.
Ensino de Química sob a visão de Bachelard: Investigação dos obstáculos epistemológicos no tópico modelos atômicos.
Authors: Alves Silveira Felipe , Karine Portela Vasconcelos Ana , Do Nascimento Almeida Suyanne , Bandeira dos Santos Neto Manuel
Published: April 2019

A utilização de metáforas e/ou analogias pelos docentes são geralmente usadas para que os estudantes possam compreender o conceito científico. Os professores acabam condicionando a formação de obstáculos epistemológicos na sala de aula através desses recursos, onde causam estagnação da formulação e construção do pensamento. A presente investigação tem por objetivo geral identificar possíveis obstáculos epistemológicos sob a visão de Gaston Bachelard no ensino de Química referente à evolução dos modelos atômicos e com isso colaborar na formação continuada dos professores. A pesquisa foi realizada com estudantes da 1° série do ensino médio e com os professores de Química da escola. Na maior parte das respostas dos estudantes foram evidenciados possíveis obstáculos. As distorções conceituais em torno de figuras, analogias, dificultam o entendimento do conhecimento científico e, consequentemente, farão com que os estudantes adquiram concepções errôneas, equivocadas no conteúdo abordado. É imprescindível a formação continuada dos professores em que o estudo sobre a formação desses obstáculos é importante para o seu aperfeiçoamento profissional. A pesquisa proporcionou aos professores, dentro da sua formação, uma análise mais detalhada de abordar os assuntos de Química para que sejam evitados a formação de obstáculos epistemológicos.
As TIC na prática pedagógica de professores de Ciências no viés construtivista.
Authors: Souza Rosangela Vieira de , Tolentino-Neto Luiz Caldeira Brant
Published: April 2019

Este artigo apresenta alguns resultados de uma pesquisa realizada no período de abril a julho de 2015 em escola de Ensino Fundamental II da sede do Município de Senhor do Bonfim-BA. A pesquisa teve como objetivo identificar estratégias de uso das TIC e seus recursos no ensino de ciências, bem como relacionar a abordagem teórica que sustenta o uso de tais estratégias. Para alcançar tais objetivos foram entrevistados vinte e seis professores que lecionam ciências em dezessete escolas. Os resultados apontam que os professores utilizam as TIC para preparar suas aulas, consideram estas ferramentas, bastante enriquecedora para o processo de ensino-aprendizagem, e, a maioria dos docentes faz uso das tecnologias nas atividades de ensino. Houve um destaque para o uso de ferramentas de projeção de som e imagem que visam envolver os alunos na aula e melhorar a aprendizagem através da visualização de imagens, vídeos e modelos.
Uso do ambiente Code.org para ensino de programação no Ensino Fundamental I - uma experiência no Desafio Hora do Código.
Authors: Kaminski Márcia Regina , Boscarioli Clodis
Published: April 2019

Resumo: O ensino de programação pode oferecer importantes contribuições ao desenvolvimento dos estudantes. Vários movimentos incentivam o ensino de programação nas escolas por meio de eventos como os da Hora do Código. A plataforma Code.org é um ambiente utilizado para promoção destes eventos que disponibiliza gratuitamente jogos educacionais para o ensino de programação. Este trabalho relata a experiência da participação de alunos de 2º a 5º ano de Ensino Fundamental I de uma escola pública em um destes eventos ocorrido no Estado do XXXXXX. Os resultados positivos motivaram a escola a estender as atividades com a plataforma Code.org para alunos de 1º ano e Educação Infantil. Os resultados dessas experiências são também detalhados.

Abstract: The teaching of programming is gaining space in the school environment given the contributions it can offer to student development. Several movements encourage this work in schools through events such as Hora do Código. The Code.org platform is an environment used to promote these events that provides free educational games for programming learning. This paper reports the experience of the participation of students from 2nd to 5th year of Elementary School I of a public school in one of these events occurred in the State of XXXX. The positive results motivated the school to extend its activities with the Code.org platform for 1st year students and Early Childhood Education. The results of these experiments are also detailed.

 
Dual labeling with 5-aminolevulinic acid and fluorescein in high-grade glioma surgery with a prototype filter system built into a neurosurgical microscope: technical note
Authors: Suero Molina Eric , Ewelt Christian , Warneke Nils , Schwake Michael , Müther Michael , Schipmann Stephanie , Stummer Walter
Published: April 2019

OBJECTIVE

Recent efforts to improve visualization of 5-aminolevulinic acid (5-ALA)–induced protoporphyrin IX (PPIX) fluorescence resulted in a dual-labeling technique, combining it with fluorescein sodium in a prototype setup. Fluorescein identifies regions with blood-brain barrier breakdown in gliomas. However, normally perfused and edematous brain fluoresces unselectively, with strong background enhancement. The aim of this study was to test the feasibility of a novel, integrated filter combination using porphyrins for selective tumor identification and fluorescein for background enhancement.

METHODS

A microscope with a novel built-in filter system (YB 475) for visualizing both fluorescein and 5-ALA–induced porphyrins was used. Resection limits were identified with the conventional BLUE 400 filter system. Six patients harboring contrast ring-enhancing lesions were analyzed.

RESULTS

The complete surgical field could now be illuminated. Fluorescein was helpful for improving background visualization, and enhancing dura, edematous tissue, and cortex. Overlapping regions with both fluorophores harbored merged orange fluorescence. PPIX fluorescence was better visualized, even in areas beyond a normal working distance of approximately 25 cm, where the BLUE 400 filters recognized no or weak fluorescence.

CONCLUSIONS

The novel filter system improved general tissue brightness and background visualization, enhancing fluorescence-guided tumor resection. Furthermore, it appears promising from a scientific perspective, enabling the simultaneous and direct observation of areas with blood-brain barrier breakdown and PPIX fluorescence.
Outcome analysis of surgery for symptomatic spinal metastases in long-term cancer survivors
Authors: Barzilai Ori , McLaughlin Lily , Lis Eric , Yamada Yoshiya , Bilsky Mark H. , Laufer Ilya
Published: April 2019

OBJECTIVE

As patients with metastatic cancer live longer, an increased emphasis is placed on long-term therapeutic outcomes. The current study evaluates outcomes of long-term cancer survivors following surgery for spinal metastases.

METHODS

The study population included patients surgically treated at a tertiary cancer center between January 2010 and December 2015 who survived at least 24 months postoperatively. A retrospective chart and imaging review was performed to collect data regarding patient demographics; tumor histology; type and extent of spinal intervention; radiation data, including treatment dose and field; long-term sequelae, including local tumor control; and reoperations, repeat irradiation, or postoperative kyphoplasty at a previously treated level.

RESULTS

Eighty-eight patients were identified, of whom 44 were male, with a mean age of 61 years. The mean clinical follow-up for the cohort was 44.6 months (range 24.2–88.3 months). Open posterolateral decompression and stabilization was performed in 67 patients and percutaneous minimally invasive surgery in 21. In the total cohort, 84% received postoperative adjuvant radiation and 27% were operated on for progression following radiation. Posttreatment local tumor progression was identified in 10 patients (11%) at the index treatment level and 5 additional patients had a marginal failure; all of these patients were treated with repeat irradiation with 5 patients requiring a reoperation. In total, at least 1 additional surgical intervention was performed at the index level in 20 (23%) of the 88 patients: 11 for hardware failure, 5 for progression of disease, 3 for wound complications, and 1 for postoperative hematoma. Most reoperations (85%) were delayed at more than 3 months from the index surgery. Wound infections or dehiscence requiring additional surgical intervention occurred in 3 patients, all of which occurred more than a year postoperatively. Kyphoplasty at a previously operated level was performed in 3 cases due to progressive fractures.

CONCLUSIONS

Durable tumor control can be achieved in long-term cancer survivors surgically treated for symptomatic spinal metastases with limited complications. Complications observed after long-term follow-up include local tumor recurrence/progression, marginal tumor control failures, early or late hardware complications, late wound complications, and progressive spinal instability or deformity.
Outcome of unilateral versus standard open midline approach for bilateral decompression in lumbar spinal stenosis: is “over the top” really better? A Swiss prospective multicenter cohort study
Authors: Ulrich Nils H. , Burgstaller Jakob M. , Gravestock Isaac , Pichierri Giuseppe , Wertli Maria M. , Steurer Johann , Farshad Mazda , Porchet François
Published: April 2019

OBJECTIVE

In this retrospective analysis of a prospective multicenter cohort study, the authors assessed which surgical approach, 1) the unilateral laminotomy with bilateral spinal canal decompression (ULBD; also called “over the top”) or 2) the standard open bilateral decompression (SOBD), achieves better clinical outcomes in the long-term follow-up. The optimal surgical approach (ULBD vs SOBD) to treat lumbar spinal stenosis remains controversial.

METHODS

The main outcomes of this study were changes in a spinal stenosis measure (SSM) symptoms score, SSM function score, and quality of life (sum score of the 3-level version of the EQ-5D tool [EQ-5D-3L]) over time. These outcome parameters were measured at baseline and at 12-, 24-, and 36-month follow-ups. To obtain an unbiased result on the effect of ULBD compared to SOBD the authors used matching techniques relying on propensity scores. The latter were calculated based on a logistic regression model including relevant confounders. Additional outcomes of interest were raw changes in main outcomes and in the Roland and Morris Disability Questionnaire from baseline to 12, 24, and 36 months.

RESULTS

For this study, 277 patients met the inclusion criteria. One hundred forty-nine patients were treated by ULBD, and 128 were treated by SOBD. After propensity score matching, 128 patients were left in each group. In the matched cohort, the mean (95% CI) estimated differences between ULBD and SOBD for change in SSM symptoms score from baseline to 12 months were −0.04 (−0.25 to 0.17), to 24 months −0.07 (−0.29 to 0.15), and to 36 months −0.04 (−0.28 to 0.21). For change in SSM function score, the estimated differences from baseline to 12 months were 0.06 (−0.08 to 0.21), to 24 months 0.08 (−0.07 to 0.22), and to 36 months 0.01 (−0.16 to 0.17). Differences in changes between groups in EQ-5D-3L sum scores were estimated to be −0.32 (−4.04 to 3.40), −0.89 (−4.76 to 2.98), and −2.71 (−7.16 to 1.74) from baseline to 12, 24, and 36 months, respectively. None of the group differences between ULBD and SOBD were statistically significant.

CONCLUSIONS

Both surgical techniques, ULBD and SOBD, may provide effective treatment options for DLSS patients. The authors further determined that the patient outcome results for the technically more challenging ULBD seem not to be superior to those for the SOBD even after 3 years of follow-up.
Determination of dynamic instability in lumbar spondylolisthesis using flexion and extension standing radiographs versus neutral standing radiograph and supine MRI
Authors: Chan Vivien , Marro Alessandro , Rempel Jeremy , Nataraj Andrew
Published: April 2019

OBJECTIVE

In this study the authors sought to compare the proportion of patients with lumbar spondylolisthesis detected to have dynamic instability based on flexion and extension standing radiographs versus neutral standing radiograph and supine MRI.

METHODS

This was a single-center retrospective study of all consecutive adult patients diagnosed with spondylolisthesis from January 1, 2013, to July 31, 2018, for whom the required imaging was available for analysis. Two independent observers measured the amount of translation, in millimeters, on supine MRI and flexion, extension, and neutral standing radiographs using the Meyerding technique. Interobserver and intraobserver correlation coefficients were calculated. The difference in amount of translation was compared between 1) flexion and extension standing radiographs and 2) neutral standing radiograph and supine MRI. The proportion of patients with dynamic instability, defined as a ≥ 3 mm difference in the amount of translation measured on different imaging modalities, was reported. Correlation between amount of dynamic instability and change in back pain and leg pain 1 year after decompression and instrumented fusion was analyzed using multivariate regression analysis.

RESULTS

Fifty-six patients were included in this study. The mean patient age was 57.1 years, and 55.4% of patients were female. The most commonly affected levels were L4–5 (60.7%) and L5–S1 (30.4%). The average translations measured on flexion standing radiograph, extension standing radiograph, neutral standing radiograph, and supine MRI were 12.5 mm, 11.9 mm, 10.1 mm, and 7.2 mm, respectively. The average difference between flexion and extension standing radiographs was 0.58 mm, with dynamic instability detected in 21.4% of patients. The average difference between neutral standing radiograph and supine MRI was 3.77 mm, with dynamic instability detected in 60.7% of patients. The intraobserver correlation coefficient ranged from 0.77 to 0.90 mm. The interobserver correlation coefficient ranged from 0.79 to 0.86 mm. In 44 patients who underwent decompression and instrumented fusion, the amount of dynamic instability between standing and supine imaging was significantly correlated with change in back pain (p < 0.001) and leg pain (p = 0.05) at the 12-month postoperative follow-up. There was no correlation between amount of dynamic instability between flexion and extension standing radiographs and postoperative back pain and leg pain.

CONCLUSIONS

More patients were found to have dynamic instability by using neutral standing radiograph and supine MRI. In patients who received decompression and instrumented fusion, there was a significant correlation between dynamic instability on neutral standing radiograph and supine MRI and change in back pain and leg pain at 12 months.
PECULIARITIES OF CHANGES IN LYMPH COMPOSITION IN DIFFERENT FORMS OF LYMPHADENITIS MAXILLOFACIAL AREA IN CHILDREN
Authors: Tkachenko P.I. , Bilokon S.O. , Lokhmatova N.M. , Korotych N.M. , Lobach Yu.B.
Published: April 2019

This literature review highlights the role of the immunocompetence of the lymph substance and the oral mucosa in various clinical forms of lymphadenitis of the maxillofacial area in children. The purpose of the work was to conduct a reflective analysis of the importance of their protective responses in the development of inflammation in regional lymph nodes. According to modern conceptions about the morpho-functional significance of the lymphatic system, it is considered first of all as one of the components of the body protective system, which is anatomically closely related to the vascular system and includes capillaries, lymphatic vessels, lymph nodes, trunks and ducts through which the lymph flows from organs and systems to the site of the merge of the internal jugular and subclavian veins. In response to entering foreign particles bearing signs of alienation into the body, lymphocytes and related antibodies are being produced in the organs of the lymphatic system and then are transferred to the site of injury through the lymphatic passageways, where the immune response takes place. The presence of a significant number of nosological forms of the disease, the factors contributing to the development of acute or chronic inflammation in the lymph nodes of the face and neck can be explained by the diversity of functions performed by them and the imperfect level of the development of structural elements of the immune system in children at the general and local levels. According to the fact that the oral mucous membrane is borderline anatomical substance through which the antigenic loading is directly carried out, it is its immunocompetence that can greatly affect on the high probability of the development of inflammatory processes of odontogenic and non-odontogenic origin. The lack of in-depth information about the multifactorial mechanisms of the aetiology and pathogenesis of lymphadenitis of the maxillofacial area of different genesis in children causes poses some difficulties in their understanding, especially in children with signs of the developmental disorders in the antenatal and early postnatal periods that influences ontogenesis, thus impacting the strength of the body systemic and local immune responses. Therefore, the study of the morphological and immunohistochemical architectonics of certain sections of the oral mucosa and regional lymphatic formations including investigation of the level of their nonspecific and specific protection is an important factor in substantiating the appropriateness to include immunocorrection medicines of different pharmacological actions into the integrated therapy.
INFLUENCE OF DISEASE ON THE QUALITY OF LIFE OF PATIENTS WITH EXTRASPHINCTERIC AND TRANSSPHINCTERIC PARARECTAL FISTULAS
Authors: Dudchenko M.O. , Mishura Z.I.
Published: April 2019

Relevance. The presence of high transsphincteric and extrasphincteric anal fistulas can cause severe local changes such as significant deformation of the anal canal, perineum, and resulting in anal incontinence, which significantly impairs the quality of life of these patients. Objectives: to evaluate the quality of life of patients with chronic paraproctitis, using a comparative analysis of the studied groups. Objects and methods. The study involved 58 patients who had different forms of chronic paraproctitis treated in proctology department of M.V. Sklifosovsky Poltava Regional Clinical Hospital and in the surgical department of Poltava City Clinical Hospital #3. Results. While studying the anamnesis, it was found that the duration of the disease in patients varied from 2-3 months to 10 years or more, an average of 2.9 ± 0.9 years. Patients involved in physical labour made up 82.7%, slightly fewer patients were engaged in mental work, 20.6%, even less people were involved in combined type of activity, 10.4%. In 32 (55.2%) patients, other coloproctological diseases were detected, and some of them had 3 or more diseases at the same time. The most common complaint (100%) was the presence of an external fistulous aperture in the perianal region. Pain was reported by 48 (82.8%) people. In this case, it was also found that the frequency of this complaint increased with a longer medical history (76.2% in patients with anamnesis up to 1 year, compared with 92.9% in patients with chronic paraproctitis over 5 years). In 22 (37.9%) patients there were complaints of a periodic increase in body temperature that is associated with an aggravation of the chronic process. Conclusion. Thus, most patients search for medical care in the late stages of the disease - on the average 3 years after the onset of the first symptoms. Moreover, in patients with a long history of the disease, symptoms become more severe that significantly impairs the quality of their lives. The vast majority of patients with anal fistulas are engaged in physical labour, and it is the fact that the pain in chronic paraproctitis exacerbated during physical activity makes patients with this pathology ask for medical aid.
EFFECT OF A WATER-SOLUBLE FORM OF QUERCETIN ON THE DISINTEGRATION OF PERIODONTAL ORGANIC MATRIX IN RATS EXPOSED TO THE SYSTEMIC ADMINISTRATION OF SALMONELLA TYPHI LIPOPOLYSACCHARIDE
Authors: Yelins’ka A.M. , Kostenko V.O.
Published: April 2019

The experiment on 30 white rats was designed to investigate the effect of a water-soluble form of quercetin on collagenolysis and depolymerization of proteoglycans and glycoproteins in both soft and bone tissues of periodontium under the conditions of systemic administration of S. typhi lipopolysaccharide. The animals were divided into 3 groups: the 1st group included intact animals, the 2nd group involved the animals exposed to the systemic administration of S. typhi lipopolysaccharide (pyrogenal), the 3rd group was made up the rats, which were given a water-soluble complex of quercetin and polyvinylpyrrolidone (corvitin) intraperitoneally in a dose of 500 mg / kg (10 mg / kg in terms of quercetin) every 3 days, starting from the 30th day of the experiment. The latter was administered in a dose of 0.4 μg/kg 3 times during the 1st week and once a week for the next 7 weeks. Collagenolysis was assessed by the concentration of free hydroxyproline; the level of depolymerisation of proteoglycans and glycoproteins was assessed by the content of glycosaminoglycans (GAGs) and N-acetylneuraminic acid (NANA) respectively. The introduction of quercetin in the experimental conditions significantly reduced the concentration of free hydroxyproline in soft and bone periodontal tissues by 27.3 and 26.7%, GAG – by 36.3 and 39.9%, and NANA – by 17.6 and 46.8%, respectively compared to the values of the 2nd group. The coefficient of root exposure in molars was inferior to the findings in the group with the modelled systemic inflammatory response by 26.9%. It can be concluded that the use of quercetin in the systemic lipopolysaccharide administration significantly reduces the depolymerisation of the components of the organic matrix in soft and bone periodontal tissues (collagen, proteoglycans and sialoglycoproteins), and limits the resorption of the alveolar process in jaws.
CONSISTENT PATTERNS OF POSTMORTAL STRUCTURAL AND BIOCHEMICAL CHANGES IN DIAPHRAGM MUSCULAR TISSUE: IMPORTANCE FOR FORENSIC MEDICAL ESTIMATION OF TIME OF DEATH COMING
Authors: Konoval N.S.
Published: April 2019

The issue on estimating the time of death coming still remains a challenge that requires a lot of questions to be answered, therefore, the development of new scientific methods aimed at overcoming these difficulties is a top priority in solving the problem of estimating the time of death coming.

The purpose of this study was to investigate the structural and biochemical changes in the muscle tissue of the diaphragm in the early post-mortem period.

The muscular tissue samples of the diaphragm just below the lungs taken from 30 human corpses in the early post-mortem period (in time intervals of 3-13 hours from the onset of death) were investigated. We studied structural and biochemical markers in the homogenates of the muscles of the diaphragm: the content of glycogen, acid phosphatase, lactate, lactate dehydrogenase, lipofuscin, and cholinesterase. It was found out that in the early post-mortem period structural and biochemical changes in the muscle tissue of the diaphragm are characterized by regular morphological biochemical and biophysical changes. In particular, the post-mortem dynamic changes in glycogen, acid phosphatase and lipofuscin levels is most significant; i.e. within the time interval of 3–9 hours from the time of death coming, the assessment of the “cholinesterase / glycogen or acidic phosphatase / glycogen” ratio is the most diagnostically valuable, then after 9 hours the only “cholinesterase / glycogen” ratio is meaningful.

The content of glycogen in the homogenates of the diaphragm muscle tissue depending on the time of death coming ranged from (4.765 ± 0.058) mg / g in 3 hours, to (1.883 ± 0.027) mg / g in 13 hours after the death coming, reliably ( p <0.001) differing in time intervals. The inverse pattern was characterized by the acid phosphatase content: (2.748 ± 0.019) u / g in 3 hours and (4.49 ± 0.032) u / g in 13 hours. These markers are the most significant to demonstrate the patterns and can be used as critically important signs in forensic diagnosis.
THE ROLE OF THE ORGANIZATION AND METHODOLOGICAL SUPPORT OF THE EDUCATIONAL PROCESS ON FUNDAMENTAL DISCIPLINES TO ENSURE THE HIGH RESULTS OF SUBTEST DURING THE LICENSING EXAM “KROK-1”
Authors: Devyatkina N.M.
Published: April 2019

Medical licensing examination has been known as a common evaluation system for medical students, therefore, it is important to collect the relevant information and adopt best practice developed by the medical educational settings whose students demonstrate the highest results. The purpose of this work is to analyze the organization of the educational process and its methodological support at the Department of Experimental and Clinical Pharmacology, Ukrainian Medical Stomatological Academy that allowed the students to get high rates on the subtest for Pharmacology as a constituent of the licensing examination “Krok-1”. A quantitative analysis of the scores obtained on the Pharmacology subtest of the “Krok-1” examination (2015-2018) was carried out and the components of the educational process that provided these results were discussed. It has been shown that the results of “Krok-1”, Pharmacology, shown by the students of the Academy rank the 1st – 2nd places among other disciplines, and the percentage of this subtest exceeds the values of the national level. The constancy of high results gives grounds to consider the proper organization of the educational process and its material support at the department of Pharmacology are the main support. A three-stage system of students preparing to the “Krok-1” examination from problem-solving lectures at the 1st stage toward the independent study of the material at the 2nd stage and applying a variety of teaching and knowledge control methods at the 3rd (classroom) stage, including the experiment, thematic testing, work in a computer class. To prepare students for the “Krok-1” examination, methodical materials are offered and displayed on the website of the department, full provision with modern basic textbook and manuals. Thus, regarding high results obtained by the students passing the subtest “Krok-1”, it seems quite reasonable to summarize and share the experience of teaching Pharmacology, based on using multi-level teaching technologies and proper methodological support.
Technological drivers of development of the market of tourist services
Authors: Shpyrnya O. V.
Published: April 2019

This article analyzes the main technological drivers of changes in the market of tourist services that have occurred recently. The basic trends in the development of the tourist market have been studied. It is concluded that today the majority of tourists use the resources of the Internet when organizing travel. The basic trends in the development of the tourist services market over the past few years were reviewed, highlighting the main aspects. The tendency of diversification of the tourist business and expansion of the product offer due to direct online distribution has been noted.

The main driver of the development of the tourist market was the change in consumer behavior of tourists and their “movement” into the Internet space. An important trend is the increasing interest of tour operators to the B2C segment with the simultaneous offer of services for direct online distribution on corporate sites. It was revealed the active development of aggregators (consolidators) of tourist services in the market, a high level of capitalization of digital companies in the field of tourism.

The technological drivers in the market of tourist services included the activities of search engines, first of all, Yandex and Google, as well as the development of start-ups offering special, highly specialized services for tourists.
Interdisciplinary approach in research and teaching: advantages and problems of application
Authors: Kreps T V.
Published: April 2019

The article deals with the interdisciplinary approach as an interdependent system of knowledge integration, expressed in research and teaching.

The interpretation of the term “interdisciplinary approach in research and training” by E.M. Mirsky is taken as a basis, he interdisciplinary interaction is considered as a relationship between the systems of disciplinary knowledge in the process of integration and differentiation of sciences and collective forms of work of scientists in different fields of knowledge in the study of the same object.

The article is based on an interdisciplinary approach the scientific base and system of education as a complex of fundamental and taxonomic disciplines are considered. The interdisciplinary connections with the focus on the effectiveness of training are considered. It contains the consistency of educational programs, determined by didactic goals and content. Interdisciplinary connections with the competence approach allow transferring knowledge, skills and abilities from one sphere of science and professional activity to another. Interdisciplinary approach is aimed at linking academic disciplines.

There are several formats of implementation of an interdisciplinary approach to teaching at universities in the specialty “Economics”, based on an interdisciplinary approach offers to form the competence in the study of economic disciplines.

The contradictions in the assimilation of knowledge, ideas and researching methods between the Sciences are smoothed out, and there is a complex application of the theory and practice obtained on the basis of the study of disciplines in professional activities. Both significant advantages and problems arising from the use of an interdisciplinary approach are noted.
Homo creators: deconstruction of the diverging way of thinking
Authors: Chumicheva N. V.
Published: April 2019

The problem with generating advertising ideas, metaphors, narrative strands for video commercials, podcasts, and nontrivial script languages are on the copywriter’s agenda almost every day. The mass-produced creative approach is quite difficult, as far as “the Muse is mute” being an unachievable goal. The proposed article attempts to analyze the stages of creative impulse from the point of view of the psychological structure of associative thinking intuitive notion impulsive insights, and its correlation with the structure of consciousness.

The article analyzes the convergent, and divergent pathways of the neural ensembles of the brain at all modeled spontaneous, or planned stages of the Muse’s first indications (‘AHA! ‘moment or sudden creative insight). The structure of non-trivial advertising images and original ideas in catching psycho-triggers; principles of brain’s working performance in an inspired moment; the whole creative process in challenging situations – the author tries to answer these and other question, to draw some conclusions against the present neuropsychological background.
Features of small forms of soviet autonomy in Kuban in the first half of the XX century: on the example of the Armenian district
Authors: Ryabchenko A. G. , Zolotareva I. D.
Published: April 2019

At different stages of Soviet historiography, priorities in studying the history of the national administrative organization of the small peoples of the USSRoften changed for various reasons, but it always evoked constant interest. The Communist Party of the CPSU (b), which was ruling in Soviet Russia in the early 1920s, Leninist national policy greatly contributed to the emergence of a number of autonomous administrative-territorial formations that were national in nature and had a very different status. The territorial national status varied from high status of an autonomous republic, an autonomous region to an autonomous region, and even a national village council. Those. a separate settlement. In the Southeast, and later the North Caucasusregion of the RSFSR, already in the early 1920s. National administrative districts received existence as national autonomies of a regional scale, including the Armenian National District. This article is dedicated to this area.
Modern condition of state support of agriculture of the Vologda region
Authors: Patrakova S. S.
Published: April 2019

Currently, agriculture is one of the priority sectors of the Russian economy. In view of the requirements for quality, quantity of products and the presence of specific features of business activities, agricultural producers need government support. The aim of the work was to assess the state support provided for agriculture in Russia, regions of the European North of Russia, and mainly in the Vologda region. It has been proposed, when providing state support, to take into account such areas as the formation of a comfortable environment for work and life in rural areas in order to attract personnel to the industry; in order to consolidate the actions of the state and business, it was proposed to organize “round tables” with the participation of persons interested in the development of the industry; Also of interest is the development of a system for acquiring agricultural equipment on the terms of leasing, hiring, and rating due to the poor state of the material and technical base.
Features of forming the regional meat-industry balance models
Authors: Sidorov M. A.
Published: April 2019

The article discusses the nature and history of the development of intersectoral balance models, the specifics of their construction, questions the feasibility of expanding the practice of applying the balance sheet liability method and reflect the advantages of its use in the context of development of regional socio-economic systems. Despite the fact that the region is an independent separate system, it is economically connected with the external environment, the structure of its production is influenced from the outside by commodity and financial flows and prices in the markets of goods and services. These interrelations have quantitative and qualitative characteristics, to quantitative it is possible to refer branch volumes of the made and consumed resources, to qualitative-their interindustry proportions. The basis for the purpose of trade is the cost of production, which varies by industry specialization of the regions within the framework of the combined interregional and international division of labor, which formed the value chain. As an example, given the cost factors in the production of food processing industry of the Vologda region compared to the national average, the conclusion is made about the availability of measurable quantitative differences between them.