bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic magnetic-resonance cystography in diagnosis of perivesical fat invasion in bladder cancer
Authors: Grigoriev E. G. , Frolova I. G. , Usynin E. A. , Vasiliev N. V. , Usova A. V. , Trukhacheva N. G. , Velichko S. A.
Published: January 2020

Objective: to evaluate the diagnostic capabilities of the dynamic magnetic-resonance cystography technique in detecting invasion of perivesical fat in case of bladder cancer.

Materials and methods. The study included 125 patients (105 male and 20 females, mean 62.6 Ѓ} 11.0 years) with transitional cell carcinoma of the bladder. To assess the accuracy of the dynamic cystography method, cases with a tumor size of more than 20 mm, affecting the wall outside the bladder triangle, were selected with suspicion of perivesical fat invasion on magnetic-resonance scans. A furacilin solution was fractional injected into the catheterized bladder to obtain repeated series of T2‑haste-FS images until the bladder was completely expanded.

Results. In postprocessing, the selection of areas of interest (ROI) was performed along the contour of the affected wall in the cross section through the center of the tumor. Comparison of the displacement of the affected and intact walls by a diagram of the values of the intensity of the magnetic-resonance signal in the dynamics of bladder dilatation was evaluated. The verification method was the morphological study of the surgical material after the operative treatment. The limit of values with a more likely lesion of perivesical fat was found, which is less than 11 % of the intensity change of the magnetic-resonance signal in selected ROIs during bladder wall expansion.

Conclusion. The effectiveness of dynamic magnetic-resonance cystography in the differential diagnosis of perivesical fat infiltration in bladder cancer is characterized by a sensitivity of 90.0 %, a specificity of 93.3 %, and an accuracy of 92.0 %. The proposed technique improves the accuracy of the magnetic resonance imaging method with suspected infiltration of perivesical fat and is well tolerated by patients.
Experience of application of proproceptive modeling of walking in children of early age with motor disorders
Authors: Prityko A. G. , Chebanenko N. V. , Zykov V. P. , Sokolov P. L. , Bukreeva E. A. , Sednenkova T. A. , Sergeenko E. Yu.
Published: January 2020

Background. In the pathogenesis of cerebral palsy, the pathology of the proprioceptive modality plays an important role. Proprioceptive correction is an effective method for habilitation of children suffering from this disease. "Stimulation of the feet" is one of the methods of proprioceptive correction. In the process of treatment, pressure is applied to the receptor zones of the feet with pneumatic elements. The pressure is produced in walking mode and simulates the effect of the step on the foot. Objective: the rehabilitation treatment of children with the consequences of perinatal damage to the central nervous system and various forms of cerebral palsy.Materials and methods. The results of the rehabilitation treatment of 51 children with the consequences of perinatal damage to the central nervous system in 2 age groups: from 7 months to 1 year and from 1 year to 2 years are described. The average age of children was 1.8 ± 0.054 years, standard deviation 0.385. Among them, 27 (52.9 %) were boys, 24 (47.1 %) girls. The children had various motor dysfunctions. Children with a predominance of spasticity in the muscles of the lower extremities were 70.6 %, children with a predominance of reduced tone in the muscles of the lower extremities were 29.4 %. Rehabilitation treatment was carried out from the simulator of the base load "Сorvit". The course of basic stimulation was 10 procedures lasting from 10 to 15 minutes. The mode of stimulation was selected individually as in the classroom for physiotherapy. The duration and intensity of the pressure on the foot were selected.Results. As a result of treatment, positive dynamics of motor functions was noted. It was expressed in the normalization of muscle tone and with its decrease, and with an increase. The effect of tonic reflexes decreased. In the older group, normalization of the step structure was revealed. A reliable positive dynamics of speech and mental development was recorded. In children aged 7 months to a year with severe spastic paresis, it was statistically significant (p <0.05).Conclusions. Support stimulation is an effective and safe method of physical habilitation of children with the effects of perinatal brain lesions and cerebral palsy.
BAZI İNSANLAR MATEMATİKSEL YETENEKLE Mİ DOĞMAKTADIR? MATEMATİK ÖĞRETMENLERİNİN VE MATEMATİK ÖĞRETMENİ ADAYLARININ MATEMATİKSEL YETENEK HAKKINDAKİ İNANÇLARI
Authors: Aydın Mehmet
Published: January 2020

Bu araştırma, ortaöğretim matematik
öğretmenlerinin ve öğretmen adaylarının matematik yetenek hakkındaki
görüşlerini belirlemek amacıyla yapılmıştır. Araştırmada, “Matematik yapmak doğuştan sahip olunan
bir yetenek mi, yoksa sonradan geliştirilebilir mi?” “Matematik yetenek bazı
insanların doğuştan sahip oldukları bir armağan mı, yoksa her bireyin sonradan
geliştirebileceği bir beceri midir?” “Başarılı öğrenci kimdir?” ve “Matematik
nasıl çalışılır?” gibi sorulara yönelik ortaöğretim matematik öğretmenlerinin ve
öğretmen adaylarının görüşleri değerlendirilmiştir. Nitel bir yaklaşımla yürütülen araştırmada, gelişimsel araştırma
türlerinden biri olan kesit alma (cross-sectional) yöntemi kullanılmıştır. Araştırmanın
örneklemi, 10 lise matematik öğretmeni ve 2 matematik öğretmen adayından
oluşmaktadır. Araştırmada veri toplama aracı olarak, araştırmacı
tarafından geliştirilen ve açık uçlu sorulardan ve senaryo tipi sorulardan
oluşan bir mülakat formu kullanılmıştır. Mülakatlardan elde edilen nitel
veriler, Baxter Magolda (1992)’nın Epistemolojik Yansıtma Modeli esas alınarak,
içerik analizine tabi tutulmuştur. Çalışmanın sonunda öğretmen adaylarının,
öğrencilerin matematik yeteneğinin geliştirilebileceğine ve her öğrencinin matematik
öğrenebileceğine inandıkları; ortaöğretim matematik öğretmenlerinin ise,
öğrencilerin de yeni fikirler geliştirebileceklerine inandıkları ve matematik
öğrenmede onları da birer otorite olarak gördükleri belirlenmiştir. Ancak araştırmaya
katılan öğretmenlerin, özellikle başarısız öğrencilere yönelik olumsuz
görüşlere sahip oldukları görülmüştür. Araştırmanın bulgularına dayalı olarak, öğretmenlerin
sınıf pratiklerinin takip edilerek desteklenmesi gerektiği konusunda önerilerde
bulunulmuş ve ayrıca matematik yetenek hakkında katılımcıların görüşlerine
dayalı bir sınıflandırma inşa edilmiştir.
Выйти из “гетто”: о вкладе постсоветских исследований/Russian Studies в современную политическую науку
Authors: Мельвиль Андрей
Published: January 2020

Статья посвящена анализу взаимовлияний между постсоветскими/российскими исследованиями (Russian Studies) последних трех десятилетий, с одной стороны, и динамикой современной политической науки в целом и сравнительной политологии, в частности, — с другой. На материале аналитического обзора публикаций по проблематике (1) предпосылок демократии и демократизации, (2) авторитарной модернизации без демократических реформ, (3) возможностей и ограничений институционального подхода, (4) роли государства и государственной состоятельности, (5) разновидностей постсоветского авторитаризма и (6) субнациональных измерений постсоветской политики обосновывается вывод о конструктивном использовании в постсоветских исследованиях общих политологических теоретико-методологических новаций,а также обсуждается вклад этих исследований в развитие современной политической компаративистики и политической науки в целом.
Экспортный контроль как инструмент поддержания лидерства США в меняющемся мире
Authors: Всеволодовна Элина
Published: January 2020

В статье рассматриваются особенности американской системы экспортного контроля над товарами и технологиями двойного назначения, позволившие ей стать важным инструментом обеспечения национальной безопасности и внешней политики. Используя системно-исторический и системно-функциональный подходы, автор ставит задачу проанализировать эволюцию экспортного контроля сквозь призму изменений в американской концепции национальной безопасности США, а также исследовать, почему система, созданная в годы холодный войны, оказалась настолько востребованной в наши дни. Вокруг правил ЭК идет острая внутриполитическая борьба. Ведущие ведомства, поддерживаемые отдельными группами политической элиты, стараются навязать свои стратегические приоритеты. Деловые круги и научное сообщество рассматривают экспортный контроль как ограничительную меру, лоббируя смягчение режима. В статье обозначены три периода: период холодной войны, 1990-е – первое десятилетие 2000-х годов, современный этап. Это разделение достаточно условно. В рамках каждого этапа автор рассматривает развороты к ослаблению и ужесточению режима экспортного регулирования по соображениям национальной безопасности и внешней политики, факторы политического, военно-стратегического и экономического характера, дающие толчок к переоценке Соединенными Штатами концепции национальной безопасности. Особое внимание уделено политике экспортного контроля на современном этапе. Качественно расширяется трактовка национальной безопасности США вследствие дисперсии вызовов и угроз их глобальному лидерству. Эволюция режима экспортного контроля используется как механизм поддержания лидерства США в меняющемся мире, реорганизации мирового порядка в интересах США.
Как измерять мягкую силу в международных отношениях
Authors: Gallarotti Giulio
Published: January 2020

В статье формулируются предложения автора по вопросам более эффективной оценки мягкой силы в международных отношениях, а также дифференциации ее количественных показателей по категориям, в наибольшей степени соответствующим стратегии количественного анализа. В центре внимания находится наиболее популярный и широко применяемый показатель – индекс мягкой силы “The Soft Power 30 Index”. По мнению автора, распространенные методы количественного анализа мягкой силы на основе наиболее популярных наборов данных не лишены недостатков. Проанализировав эти методы, автор предлагает собственный набор индикаторов, призванный сделать анализ мягкой силы более эффективным.
Политика интеркультурализма и возможности ее применения в России
Authors: Паин Эмиль , Федюнин Сергей
Published: January 2020

Политика мультикультурализма, получившая в последней трети XX в. широкое признание как в академических, так и в политических кругах, ныне переживает кризис, требует переосмысления или замены на другую модель, способную соединить достоинства мультикультурализма в поддержании культурного разнообразия с необходимостью общественной консолидации. В статье рассматриваются преимущества пока мало известной модели управления разнообразием, получившей наименование “интеркультурализм”. Дается характеристика практики реализации концепции интеркультурализма на примере канадской провинции Квебек и программы Совета Европы “Межкультурные города” (Council of Europe’s Intercultural Cities Program). В фокусе внимания настоящей статьи – анализ возможностей применения данной модели управления в сфере урегулирования этнополитических отношений в современной России. Обосновывается необходимость обновления концепции “национальной политики” за счет включения элементов концепции интеркультурализма в ее методологию. В статье анализируются российские ограничения на использование модели интеркультурализма в практике регулирования межкультурных отношений, но одновременно указывается на сближение этнополитических тенденций, проявляющихся в России и других странах глобального Севера. Настоящая статья опирается на результаты исследовательского проекта “Новые подходы и методы регулирования этнополитических отношений на территории крупнейших городских агломераций России”, и в частности на материалы социологических исследований, проведенных в трех городах-миллионниках РФ (Пермь, Ростов-на-Дону и Уфа). Для каждого из трех кейсов предлагается анализ особенностей существующих механизмов взаимного приспособления этнически различных групп городского населения.
Anemia de células falciformes y embarazo. Reporte de caso
Authors: Guzmán-Yara Yuly Natalia , Sánchez-Gutiérrez Sandra Milena , Castaño_Bermúdez Manuel José , Flórez_Ruiz Gineth , Falla Morán Itzel Sofía , Archila-Pérez Daniela , Romero-Sánchez Daniel Alejandro
Published: January 2020

La anemia de células falciformes (ACF) es una patología con altos índices de complicaciones; además, cuando se presenta durante el embarazo su manejo se convierte en un desafío médico debido al riesgo elevado de morbimortalidad materna y perinatal. A continuación, se hace una breve revisión de la literatura sobre ACF y se describe un reporte de caso presentado en el Hospital Universitario Clínica San Rafael de Bogotá, Colombia, en el año 2018. La paciente era una primigestante en tercer trimestre del embarazo con diagnóstico de ACF que se complicó con una preeclampsia con características de severidad y concluyó en parto pretérmino. El objetivo de publicar este caso es revisar la información respecto a la incidencia y la morbimortalidad materna y perinatal de la ACF, teniendo en cuenta que debe ser manejada por un equipo multidisciplinario y que se debe hacer detección temprana de complicaciones con el fin de mejorar el pronóstico del binomio madre-hijo.
Analysis of unstable DNA sequence in FMR1 gene in Polish families with fragile X syndrome.
Authors: Milewski M , Zygulska M , Bal J , Deelen W H , Obersztyn E , Bocian E , Halley D J , Horst J , Mazurczak T
Published: January 2020

The unstable DNA sequence in the FMR1 gene was analyzed in 85 individuals from Polish families with fragile X syndrome in order to characterize mutations responsible for the disease in Poland. In all affected individuals classified on the basis of clinical features and expression of the fragile site at X(q27.3) a large expansion of the unstable sequence (full mutation) was detected. About 5% (2 of 43) of individuals with full mutation did not express the fragile site. Among normal alleles, ranging in size from 20 to 41 CGG repeats, allele with 29 repeats was the most frequent (37%). Transmission of premutated and fully mutated alleles to the offspring was always associated with size increase. No change in repeat number was found when normal alleles were transmitted.
The activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase in erythrocytes of rats with experimental neoplastic disease.
Authors: Batko J , Warchoł T , Karoń H
Published: January 2020

In erythrocytes of rats bearing Morris hepatoma 5123 the activities of superoxide dismutase, glutathione peroxidase and glutathione reductase as well as the level of reduced glutathione increased on the 10th day after transplantation of the tumor. In the second phase of the tumor growth (20 days after transplantation), the activities of glutathione peroxidase, glutathione reductase and the level of reduced glutathione in erythrocytes of the experimental animals were lower than in controls, whereas the activity of superoxide dismutase was at that time higher than in controls. On the other hand, the activity of catalase did not significantly differ from that found in healthy rats.
Molecular mechanism of thymidylate synthase-catalyzed reaction and interaction of the enzyme with 2- and/or 4-substituted analogues of dUMP and 5-fluoro-dUMP.
Authors: Rode W , Leś A
Published: January 2020

Thymidylate synthase is a target enzyme in anticancer, antiviral, antifungal and antiprotozoan chemotherapy. With two dUMP analogues, 5-fluoro-dUMP (FdUMP) and 5-(trifluoromethyl)-dUMP (CF3dUMP), strong thymidylate synthase inhibitors and active forms of drugs, the inhibition mechanism is based on the reaction mechanism. Recent comparative studies of new dUMP analogues, containing more than one substituent in the pyrimidine ring, showed that substitution of the pyrimidine ring C(4) = O group in FdUMP by either C(4) = N-OH group (in N4-hydroxy-FdCMP) or C(4) = S group (in 4-thio-FdUMP) preserves high inhibitory potency of the drug but may alter its specificity for thymidylate synthases from various sources, which differ in sensitivity to slow-binding inhibition by FdUMP. Informations suggesting mechanisms responsible for the foregoing have been reviewed, including results of molecular modeling studies suggesting interaction of the pyrimidine C(4) = O group, or its modification, with the N5,10-methylene.(ABSTRACT TRUNCATED)
Psoralen photosensitization: damages to nucleic acid and membrane lipid components.
Authors: Caffieri S , Zarebska Z , Dall'Acqua F
Published: January 2020

For decades the therapeutic properties of psoralens were related to their photochemical reactions with DNA and RNA. Such approach, although fruitful in treatments, did not explain satisfactorily the way of healing of the multitude of diseases manifested through skin disorders. The new research field presented in our review is directed to another target: the lipid components of the cell. The studies on the photobiology of phospholipids may help to elucidate the phototoxic and pigment inducing activity of psoralens.
Mutagenesis and ultraviolet inactivation of transforming DNA of Haemophilus influenzae complexed with a Bacillus subtilis protein that alters DNA conformation.
Authors: Setlow J K , Setlow B C , Setlow P
Published: January 2020

The wild-type Bacillus subtilis spore protein, SspCwt, binds to DNA in vitro and in vivo and changes the conformation of DNA from B to A. Synthesis of the cloned SspCwt gene in Escherichia coli also causes large increases in mutation frequency. Binding of SspCwt to transforming DNA from Haemophilus influenzae made the DNA resistant to ultraviolet (UV) radiation. The mutant protein, SspCala, which does not bind DNA, did not change the UV resistance. The UV sensitivity of the DNA/SspCwt complex was not increased when the recipients of the DNA were defective in excision of pyrimidine dimers. These data indicate that the H. influenzae excision mechanism does not operate on the spore photoproduct formed by UV irradiation of the complex. Selection for the streptomycin- or erythromycin-resistance markers on the transforming DNA evidenced significant mutations at loci closely linked to these, but not at other loci. SspCwt apparently entered the cell attached to the transforming DNA, and caused mutations in adjacent loci. The amount of such mutations decreased when the transforming DNA was UV irradiated, because UV unlinks linked markers.
Minería del platino y el oro en Chocó: pobreza, riqueza natural e informalidad
Authors: Lara Rodríguez Juan Sebastián , Tosi Furtado André , Altimiras Martin Aleix
Published: January 2020

En el departamento de Chocó, Colombia, está la principal extracción aluvial de metal del platino en América Latina teniendo al oro como metal asociado. Dichos metales son explotados por organizaciones artesanales e informales de pequeña escala. Este ensayo examina el desarrollo sostenible de la minería en Chocó, para ello, cataloga sus dimensiones como unidades de análisis: En la ‘social’ evidencia pobreza generalizada. En la ‘ambiental’, determina mega-diversidad dañada y en riesgo. Y en la ‘económica’, dilucida dependencia a la minería informal e ilegalidad. Así, se argumenta que “La informalidad económica impide el desarrollo sostenible de la minería del platino y el oro”, y se discuten los elementos para su transformación.
El consumo de artes escénicas en Medellín
Authors: Gómez Hernández Yadira , Ramos Ramírez Andrey , Espinal Monsalve Nora
Published: January 2020

En este trabajo se analizan los determinantes de la asistencia a espectáculos de artes escénicas en Medellín: teatro, danza y música. Con datos de la Encuesta de Calidad de Vida de Medellín 2014, se estiman modelos de elección discreta regularizados que permiten identificar las variables relevantes para explicar las decisiones de consumo cultural, y solucionan los problemas estadísticos asociados a la existencia de un alto número de variables explicativas. Los resultados muestran que el nivel de educación y las restricciones de tiempo son los determinantes más importantes de la asistencia a eventos de artes escénicas en la ciudad.
IMPLEMENTASI PENGELOLAAN KEUANGAN BADAN USAHA MILIK DESA (STUDI DESA GONDOWANGI KECAMATAN WAGIR KABUPATEN MALANG)
Authors: Rofidah Naily , Rochayatun Sulis
Published: January 2020

Village development is the focus of national development because the village is a sub-section of the national territory that directly manage the society. Nowdays villages are required to have BUMDes as a leading organization aimed to optimize village potential (Wargiyat, 2015). The management of BUMDes must be in accordance with established regulations; financial management of BUMDes is guided by Regulation of The Minister of Village (Permendes) Number 4 of 2015 and Ministry of Home Affair regulations (Permendagri) 113 of 2015. Principles that must be upheld in the management of BUMDes are cooperative, participatory, emancipatory, transparent, accountable, and sustainable.The purpose of this study is to determine the financial management of BUMDes Gondowangi in Gondowangi Village, Wagir District, Malang Regency. The type of this research is qualitative with a case study approach. The conclusions that can be taken are financial management carried out by BUMDes Gondowangi is still simple. The planning is done by holding a meeting of each unit to form the budget plan (RAB). Implementation is carried out using receipts as proof of disbursement of funds. However, the administration is done by recording cash income and expenditure. Then, Recording which is carried out is still general. Accountability is carried out by giving a report to the regional consultative committee (BPD) of Village and Community and Village Empowerment and Service (DPMD) of Malang District, as well as sending a soft file to the Ministry of Village, and delivering it to the community together with the village meeting. The accountability of regular activities in 2017 is also carried out by BUMDes Gondowangi in village meetings. Supervision in the form of guidance from the governor and regent / mayor has not been obtained by BUMDes Gondowangi.

 
The Insidensi dan Derajat Infeksi Anisakiasis pada Ikan Hasil Tangkapan di Pelabuhan Perikanan Pantai Muncar, Banyuwangi, Jawa Timur (INCIDENCE AND DEGREE OF ANISAKIASIS INFECTION IN FISH CATCHES AT THE FISHERY PORT OF MUNCAR BEACH, BANYUWANGI, EAST JAVA)
Authors: Ulkhaq Mohammad Faizal , Budi Darmawan Setia , Azhar Muhammad Hanif , Kenconojati Hapsari
Published: January 2020

The purpose of this study was to determine the incidence and degree of infection anisakiasis in fish catches at Fishery Seaport Muncar, Banyuwangi as an effort to prevent food borne diseases in humans. Fish samples from Muncar Beach Fishery Seaport, Banyuwangi consisted of tuna fish (Euthynnus sp.), bloated fish (Rastrelliger sp.), giant trevally fish (Caranx sp.) and snapper (Lutjanus sp.) with total amount 192 tail. Sample fish was dissected and examined the parasite by native method. Parasitic worms was fixed with 5% glycerine alcohol, stained with SemichenAcetic Carmine method, identified by key identification and calculated incidence and degree of infection. The highest incidence and degree of infection showed in Lutjanus sp. and Rastrelliger sp. 66.67% and 5.39, respectively, while the lowest showed in Caranx sp. from 6.67% and 0.09 respectively. Continue research to determine incidence and degree of infection anisakiasis in each season was required to mapping and to know the spread of worms Anisakis sp.
Resistensi Antibiotik pada Escherichia coli yang Diisolasi dari Daging Ayam pada Pasar Tradisional di Kota Bogor (ANTIBIOTIC RESISTANCE IN ESCHERICHIA COLI ISOLATED FROM CHICKEN MEAT OF TRADITIONAL MARKETS IN THE CITY OF BOGOR)
Authors: Januari Connie , Sudarwanto Mirnawati Bachrum , Purnawarman Trioso
Published: January 2020

Antibiotic use in farm is spread widely to treat of poultry disease including therapy, supportive or preventive use and as afeed additive to improve chicken performance. The negative effects of antibiotic use can increase the level of bacterial resistance to antibiotics. This study aimed to investigate on antibiotic resistance in Escherichia coli isolated from chicken meat that were sold in Traditional Market of Bogor City. A total of 175 samples of chicken meat were taken by purposive sampling method, out of 175 found 50 positive samples of E. coli. The samples were subjected to E. coli examination and the isolated E. coli were tested for the antibiotic resistance using eight antibiotics, i.e., amoxicillin, cefotaxime, colistin, nalidixid acid, streptomycin, erythromycin, oxytetracillin, and tetracycline. The study was conducted by using the disk diffusion method on Muller-Hinton agar according to the Clinical and Laboratory Standards Institute guidelines. The study showed E. coli isolated from chicken meat were resistance towards amoxicilin (90%), colistin (94%), nalidixid acid (86%), streptomycin (98%), erythromycin (98%), oxytetracillin (84%), tetracycline (86%), and cefotaxime antibiotics (12%). The proportion of multidrugresistant was 99%. The higher of multidrug-resistant indicated the E. coli would be a threat to public and environmental health.
Estimation of Aflatoxin M1 Exposure through Consumption of Various Dairy Milk Products in Yogyakarta, Indonesia (ESTIMASI PAPARAN AFLATOKSIN M1 MELALUI KONSUMSI BERBAGAI PRODUK SUSU DI YOGYAKARTA, INDONESIA)
Authors: Sumantri Ika , Purwanti Fitri , Nuryono Nuryono , Agus Ali
Published: January 2020

This study was conducted to investigate the occurrence of aflatoxin M1 (AFM1) in various milk products marketed in Yogyakarta Province (Indonesia) and to estimate the exposure of aflatoxin through contaminated milk consumption. Fresh milk (n=20), pasteurized milk (n=16), and recombined milk products (n=6) were sampled for AFM1 concentration testing by a competitive ELISA test using ELISA kit for AFM1 assay. A survey was conducted to interview consumers (n=88) on milk consumption habit (milk type and amount of consumption). ELISA assays showed 92.5% of samples werecontaminated with AFM1 in a range of 24-570 ng/L (average: 216 ng/L). The highest average AFM1 concentration was detected in pasteurized milk sample (244 ng/L), followed by fresh milk (219 ng/L), and the lowest was in recombined milk sample (131 ng/L). However, 100% of recombined milk samples had AFM1 concentration >50-500 ng/L. Thus, recombined milk product was most likely the main source of AFM1 intake due to its high daily consumption in all age groups. Based on AFM1 levels found in milk and consumption of corresponding milk sample, it was estimated that the overall AFM1 exposure ranges from 1.23 ng/kg body weight/day (in 6-15 year-old children) up to 5.26 ng/kg body weight/day (in 3-5 year-old children). In conclusion, this study revealed high occurrences of AFM1 dairy milk marketed in Yogyakarta. Although levels of AFM1 contamination were in Indonesian regulatory limit, high exposure of aflatoxin found in all age groups of consumer. Thus, this preliminary study provides evidence that AFM1 contaminated milk is a serious public health hazard in Indonesia.
Ekstrak Etanol Kulit Buah Jengkol Menurunkan Kadar Glukosa dan Meningkatkan Hormon Insulin Tikus Diabetes Yang Diinduksi Streptozotocin
Authors: Malini Desak Made , Madihah Madihah , Khoirunnisa Dita Aprila , Sasmita Indriani , Ratningsih Nining , Alipin Kartiawati , Hermawan Wawan
Published: January 2020

Diabetes Mellitus (DM) is a disease with metabolism disorder signed by increasing of glucose blood (hyperglicemia), caused by disorder of insulin secretion and or increasing of insulin resistance. Therapy of jengkol’s fruit peel is an alternative treatment for DM. This study aims to determine the effect of ethanol extract of jengkol’s fruit peel to decrease glucose and increase insulin level of Wistar female rats which induced by streptozotocin (STZ). This research used the experimental method of Completely Randomized Design (RAL). Rat were first induced by single intravenous injection of STZ except Negative Control. Furthermore, rats were divided into six groups, namely Negative Control (NC), Positive Control (PC), Reference Group (RG) glibenclamide 10 mg/kg BW, and ethanol extract of jengkol’s fruit peel (EEOJFP) treatment at dose of 385 (P1), 770 (P2), and 1540 (P3) mg/kg BW with four replications each. Treatment was administered orally for 14 days. Data were analyzed by analysis of variance (ANAVA) with 95% confidence level and Duncan Multiple Range Test. The result showed that treatment of EEOJFP with dose of 385, 770 and 1540 mg/ kgBW decreased blood glucose 28.6%;65.4% and 59.1% successively, increased insulin as 54%; 230% and 206%. There was a protective effect of EEOJEF to level of blood glucose and insulin secretion of rat-STZ induced. The conclusion from this research is Ethanol extract of Jengkol’s fruit peel at dose 770 mg/kg BW is an effective dose in decreasing the level of glucose and increasing the level of insulin hormone in STZinduced diabetic rats.
Penerapan Kultur Campuran Trichoderma reesei dan Aspergillus niger dalam Meningkatkan Kualitas Putak sebagai Pakan (APPLIED MIXED-CULTURED ASPERGILLUS NIGER AND TRICHODERMA REESEI TO INCREASE PUTAK QUALITY AS FEED)
Authors: Hilakore Maritje Aleonor , Suryahadi Suryahadi , Wiryawan Komang , Mangunwijaya Djumali
Published: January 2020

Putak is a local feed in west Timor, East Nusa Tenggara Province. It is obtained from soft core of palm tree which is called gebang tree (Corypha gebanga). Putak contains high carbohydrate and fiber but low in protein. As an effort to increase the ptotein level in putak a research was conducted by fermenting it with mixed-cultured of Trichoderma reesei and Aspergillus niger. A laboratorium experimental method was used and arranged factorially in Completely Randomized Design 3 x 4 x 3 namely three inoculant levels of T. reesei (T): 5,0; 7,5 and 10,0 % (w/w), and four levels of A. niger (A) 0,5; 1,0; 1,5 and 2,0% (w/w). Mixed-cultured was done by: first, T.reesei as treatment mix with putak and incubation for two days, after that mix with A.niger, incubation for two days. The best result of this study was on combination of T.reesei 7.5% level and 1,5% of A.niger were crude protein (23.62%) and soluble protein (14.92%) was highest and fiber 10,17%.
Perkembangan Sel Endometrium Domba setelah Inkubasi dalam Kolagenase dan Dikultur In Vitro dengan Estradiol dan Progesteron
Authors: Ananda Ananda , Kaiin Ekayanti Mulyawati , Karja Ni Wayan Kurniani , Setiadi Mohamad Agus
Published: January 2020

The aim of the present study was to determine the optimal incubation time of collagenase on concentration, viability, quality of endometrial cell culture, and the role of estradiol and progesterone on ovine endometrial cells proliferation. Endometrium minced was incubated into collagenase with different duration of time: 1 hour, 3 hours, and 6 hours repectively. Cell concentration and viability were calculated after incubation. The quality of cell culture was observed on 1st, 3rd, and 5th day after seeding. The best incubation result was then continued with the addition of the E2 (100 pg/ mL), P4 (100 ng/mL), E2:P4 (100 pg/mL : 10 ng/mL), and E2:P4 (10 pg/mL : 100 ng/mL) into the culture medium. After nine days, cell culture was harvested by trypsinization. Concentration and cell viability were analyzed using analysis of variance, followed by Duncan test. Quality of endometrial cell culture was analyzed descriptively. Results showed that there was a significant decreased in the concentration and cell viability obtained in each treatment of collagenase incubation time and optimum treatment of endometrial cell culture was found at 3 hours. Experiment on culture of endometrial cell revealed that proliferation rate treated by E2 and P4 was better then control (P<0.05). Futhermore, additional of E2 into the culture medium even E2 alone (100 pg/mL or higher E2 combination with P4 (100 pg/mL : 10 ng/mL) showed better proliferation rate than P4 alone (100 ng/mL) or higher P4 combination (10 pg/mL : 100 ng/mL). In conclusion, suplementation of 100 pg/mL of estradiol (E2) could support better proliferation of ovine endometrial cells in vitro.
Efektivitas Larutan Dekalsifikasi pada Os tibia Domba Garut (Ovis aries) (THE EFFECTIVENESS OF DECALCIFYING SOLUTIONS ON THE TIBIAL OF GARUT SHEEP (OVIS ARIES))
Authors: Rakhmawati Handina , Situmeang Adrian , Nurhidayat Nurhidayat , Lubis Andri Maruli Tua , Murti Harry , Boediono Arief
Published: January 2020

Bone is a tissue that has a density of extracellular matrix structures and composed by organic and inorganic components. Decalcification is a stage that plays an important role in bone histology using various types of solutions. The sample used in this study was lateral condyle from tibia of three garut sheeps (Ovis aries) which had been fixed with 10% Neutral Buffered Formalin (NBF) for 24 hours. Sample were cut into pieces ranging from 1 cm x 1 cm x 1 cm in size, the decalcification using three solutions; 10% nitric acid, 10% EDTA (pH 7.4) and 10% EDTA (pH 7.4) + TBD-1®. The aim of this study was to evaluate the effectiveness of three solutions for the decalcification process of lateral tibial condyle of garut sheep. Observation parameter in this study includes: duration of decalcification, sectioning process of ribboning formation, structural integrity and absorption of hematoxylin-eosin (HE) staining. The results shows that 10% EDTA (pH 7.4) solution provides a long duration of decalcification which is ease sectioning process ribboning, the best structural integrity of lateral tibial condyle. In hematoxylin-eosin (HE) staining shows that 10% nitric acid solution does not absorb the optimum color, opposite in 10% EDTA and 10% EDTA + TBD-1® solution, the color intensity between hematoxylin and eosin in the tissue shows the best results. Based on these results, it can be concluded that the 10% EDTA (pH 7.4) is the best decalcification solution for lateral condyle from tibial of garut sheeps.
Erkenci Bölgede Üretilen Kiraz Çeşitlerinin Depo ve Raf Ömrünün Belirlenmesi
Authors: EROĞUL Deniz , ÖZMEN Birkan
Published: January 2020

ÖZ

 

Amaç: Erkenci bölgede üretilen kiraz
çeşitlerinin hasat, depo ve raf ömrü sonrası meyve kalite özelliklerinin
belirlenmesi amaçlanmıştır.  

Materyal
ve Metot: Kiraz çeşitleri
olarak Bing, Napolyon, North Wonder, Skeena, 0900 Ziraat ve Regina
kullanılmıştır. Meyveler modifiye
atmosfer paketleme (MAP) ambalajlarında 0±0.5°C sıcaklık ve %90-95 oransal
nemde 21 gün süreyle muhafaza edilmiştir. Depolama sonrası kalite analizi
yapılırken, bir kısım meyve  3 gün
süreyle raf ömrü (20°C sıcaklık ve %65-75 oransal nem) koşullarında tutulduktan
sonra meyve kalite analizleri gerçekleştirilmiştir.

Bulgular: Regina ve 0900 Ziraat
çeşitlerinde ağırlık kaybı az olmuş, meyve sertlikleride bu çeşitler ile North
Wonder çeşidinde yüksek bulunmuştur. Bing, Napolyon ve Skeena çeşitlerinin
meyve sertlikleri ise düşük bulunmuştur. Skeena çeşidi ve 0900 Ziraat çeşidinin
meyve ağırlıkları yüksek bulunmuştur. North Wonder ve Skeena çeşitlerinin çatlama oranı yüksek
olmuştur. Diğer kalite özelliklerinden suda çözünür kuru madde ve titre
edilebilir asitlik ve renk değerlerindeki değişim ise sınırlı olmuştur. 

Sonuç: MAP
poşetleri ile depolama ve raf ömrü sonrası en iyi sonuç veren kiraz çeşitleri
0900 Ziraat ve  Regina çeşitleri olmuştur.
0900 Ziraat çeşit özellikleri bakımından öne çıkmıştır.

Anahtar sözcükler: Erkenci bölge, Depolama, Kiraz, MA paketleme, Meyve
kalitesi, Raf  ömrüDetermination of
Storage and Shelf Life of Sweet Cherry Varieties Produced in Early Region

ABSTRACT

Objectives: It was aimed to determine the fruit quality characteristics of the
cherry varieties produced in the early region after harvest, storage and shelf
life.  

Material and Method: ‘Bing’, ‘Napoleon’,
‘North Wonder’, ‘Skeena’, ‘0900 Ziraat’ and ‘Regina’ were used as sweet cherry
varieties. Fruits were stored for 21 days at 0±0.5°C temperature and 90-95%
proportional humidity in modified atmospheric packaging (MAP). While the
quality analysis was performed after storage, fruit quality analyses were
carried out after some fruits were kept under shelf life conditions (20°C
temperature and 65-75% proportional humidity) for 3 days.

Results: Weight loss in ‘Regina’ and ‘0900 Ziraat’ varieties was minimal and
fruit firmness was found to be high in ‘North Wonder’ varieties, as well as,
these varieties. ‘Bing’, ‘Napoleon’ and ‘Skeena’ varieties were found to have
low fruit firmness. The fruit weights of the ‘Skeena’ variety and ‘0900 Ziraat’
variety were found to be high. The cracking rate of the ‘North Wonder’ and ‘Skeena’
varieties was high. Other quality features including the changes of soluble contents
and titrable acidity and color values were found to be limited. 

Conclusion: The sweet
cherry varieties that give the best results after storage and shelf life with MAP
bags were 0900 Ziraat and Regina varieties. 0900 Ziraat excelled in terms of
various characteristics.

Keywords: Early area,
Storage, Sweet cherry, MA packaging, Fruit quality, Shelf life
Estrategias de dinamización de la enseñanza online del diseño = Dynamization Strategies for Online Teaching of Design
Authors: Yañez Martínez Begoña , Vega Borrego Daniel
Published: January 2020

El presente artículo aborda la necesidad de dinamizar y humanizar la educación online. Para ello aprovechamos las posibilidades que ofrecen las tecnologías al servicio de la educación para ir más allá en la enseñanza del diseño y el arte, incorporando estrategias innovadoras que motiven a los alumnos y contribuyan al desarrollo de su capacidad de trabajo tanto autónomo como colaborativo, a distancia. Para ello presentamos dos experiencias que se han puestoen acción por miembros del grupo de investigación DiSEA de UNIR, en las que se aplican las posibilidades de la enseñanza online a distancia, combinadas con facetas más lúdicas y prácticas, ayudando a asimilar los contenidos teóricos mediante la implicación de la experiencia y el protagonismo directo de los alumnos en las acciones educativas. Mostramos resultados que se extraen de estas prácticas como ejemplo de implicación y motivación de los alumnos hacia las tareas propuestas. Las conclusiones de ambas acciones son favorables y aplicables a otras experiencias similares.AbstractThis article addresses the need to humanize and make dynamic the online education. For that purpose, we will take advantage of the possibilities that education-oriented technologies have to offer. Our research goes beyond the teaching of design and art disciplines and incorporates innovative strategies that encourage students to contribute with their performance capacity in autonomous and collaborative tasks. In this pursuit, we detail two experiences that have been put into action by members of the research group DiSEA from UNIR University. These two approaches apply the possibilities of online distance learning combined with more playful and practical facets. The aim is to help students to assimilate theoretical contents with the involvement of experience and the direct leadership of students in educational actions. We show the results that can be drawn of these practices as examples of implication and motivation of students in relation with the proposed tasks. The conclusions of both actions are positive and can be applied to similar experiences.
TRANSFORMATION OF THE TERRITORIAL EDUCATIONAL SPACE AS A FACTOR OF PERFECTING THE SCIENTIFIC LIBRARY ACTIVITY
Authors: Vikhreva G. M. , Fedotova O. P.
Published: January 2020

On the example of SPSTL SB RAS, the authors illustrate how transformation of educational value basis affects ideology and technology of library activity, demanding modernization of its contents in the sphere of actual educational environmental construction.
PROBLEMS OF SEARCH FOR INFORMATION IN ELECTRONIC CATALOGS OF LIBRARIES OF VARIOUS TYPES
Authors: Stukalova A. A.
Published: January 2020

The results of the study of electronic catalogs of the largest Russian libraries of various types are presented. Particular attention is paid at search capabilities of libraries’ electronic catalogs, their availability and problems of user’s perception of the information provided.
FACEBOOK REFLECTION OF PROFESSIONAL READER’S INTERESTS OF LIBRARIANS: THE RESULTS OF ANALYSIS OF THE LIBRARY BLOGOSPHERE AND THE SOCIAL NETWORK FACEBOOK
Authors: Neshcheret M. Yu.
Published: January 2020

The article is devoted to the study of professional reader’s interests of library specialists, based on the method of analysis of library blogs and social network Facebook. The author notes the high communication potential of blogs, but emphasizes the instability of this online genre. With the advent of social networks – the author states – blogging as a tool of the Internet communication has faded into the background. At the same time, both library blogs and social networks are good sources of information about the reader’s interests of library professionals. The author distinguishes two blocks of professional reader’s interests, reflecting information needs of this professional group: general professional, caused by belonging to the professional community, and specific caused by private factors. Analysis of library blogs and social networks is the method that allows getting sufficiently objective data that is associated with psychological peculiarities of the network communication, the main of which is its informal nature, predetermined by trust relationships between the participants.
Proposição de um modelo para aprimoramento do sistema de gestão da qualidade
Authors: Barbosa Fabio Alves , Hernández Vergara Walter Roberto , Yamanari Juliana Suemi , Santos Keylla Barboza
Published: January 2020

A pesquisa propõe uma sistemática de aprimoramento de um Sistema de Gestão da Qualidade (SGQ) em pequenas e médias indústrias através da aplicação das metodologias Seis Sigma (SS) e Lean Six Sigma (LSS). Como objetivo principal da pesquisa, tem-se o desenvolvimento de um modelo de referência inédito que visa a redução da variabilidade dos recursos restritivos, diminuição de perdas, ineficiências e desperdícios, otimização do trade-off custo-qualidade dos produtos e processos, além da consolidação do conceito de Indústria 4.0. Os componentes metodológicos contemplam a pesquisa bibliográfica, descritiva, tecnológica e qualitativa. O modelo proposto, na sinergia entre Produção Enxuta e Seis Sigma, robustece e prolonga a longevidade de um sistema da qualidade industrial já existente através de ciclos de aprimoramento contínuo (kaizen) realizados com base em três grandes conjuntos de atividades orientativas e sequenciais, de modo a estabelecer a lean quality como apoio estratégico por toda a rede de operações.
Los dos Alcaldes de Zalamea. Del texto primitivo a la obra de Calderón: Marco dramático y estructura teatral
Authors: Cáseda Teresa Jesús Fernando
Published: January 2020

En este estudio llevo a cabo un análisis comparativo del primitivo Alcalde de Zalamea, especialmente espacio, tiempo, personajes y marco dramático, con la obra de Calderón de la Barca. Encuentro que el primitivo texto tiene una estructura literaria heredera de la tradición cidiana que, sin embargo, no aparece en la obra de Calderón. Analizo asimismo la presencia de la ironía en el primer texto teatral, inexistente en el otro. Concluyo que hay, por todo ello, una diferente forma de concebir el fenómeno teatral: más cercana a Lope de Vega en el primer caso y, por tanto, alejada de los presupuestos de la escuela calderoniana que aparecen en el segundo Alcalde de Zalamea.
Sistemas de representación del conocimiento para la gestión de la terminología biomédica
Authors: Varela Vila Tamara
Published: January 2020

La correcta organización y representación del conocimiento biomédico resulta imprescindible para comprender los diferentes conceptos de este amplio dominio y emplear una terminología precisa para denominarlos. En la actualidad, la aplicación en el ámbito de la terminología de las nuevas modalidades de representación conceptual, especialmente las ontologías, facilita el diseño de sistemas conceptuales dinámicos y multidimensionales independientes de la lengua. De este modo, se crean estructuras conceptuales complejas en las que se plasman no solo los diferentes conceptos sino también las relaciones existentes entre ellos, y a las que es posible vincular la terminología empleada para denominar cada uno de estos conceptos en una o varias lenguas.En este artículo se revisan los principales sistemas de representación del conocimiento biomédico de utilidad para el ejercicio de la traducción, tanto por la información conceptual como terminológica que aportan. Por un lado, se presentan aquellos sistemas que, si bien cuentan con una estructura conceptual, esta no está formalizada mediante una ontología; por otro, se analizan los sistemas de naturaleza ontológica.
Complejidad textual con fines académicos en el ámbito de la traducción. Variables para su clasificación.
Authors: Muñoz López Fernando Javier
Published: January 2020

La actividad traductora es de por sí un proceso complejo en cuanto al conocimiento. Para lograr llevar el mensaje de una lengua a otra, existen convenciones lingüísticas y culturales que deben ser consideradas. La complejidad en el ámbito terminológico (Cabré, 2003), es una variable que puede incidir directamente en el aprendizaje tanto del proceso traductor como del aprendizaje de una lengua, si no existen criterios pedagógicos claros sobre la selección de material académico para el educando. El objetivo de esta investigación fue crear un insumo para la categorización y clasificación de niveles de complejidad de textos considerando los criterios baja, media y alta complejidad, y así intentar estandarizar el proceso de selección de material para aplicar metodologías a programas universitarios de la carrera de traducción. Con lo anterior, se busca definir criterios elementales, en formato de material instruccional, para que en cada programa de estudio donde se vea reflejada la competencia del saber-hacer ligada a la traducción, la selección de textos de la lengua meta no sea sesgada al juicio experto sino a características fundamentales de selección académica para poder cumplir con las competencias y aprendizajes esperados de los programas de estudio de la carrera de traducción en INACAP Chile y su respectivo perfil de egreso. Translation activity is by nature a complex process in terms of knowledge. There are linguistic rules and cultural guidelines in order to communicate one’s message to another language. Terminology complexity (Cabré, 2003) is an important variable that can directly affect translation learning and second language acquisition, when not considering teaching criteria in selecting academic texts for the students. The final objective of this project was to create an instrument that allows teachers to select and classify the complexity levels stated in each translation class program for low, intermediate and high complexity texts. This is to standardize the text selection process to which the students are exposed to when learning translation at INACAP University. The project aims to define the fundamental criteria in an instructional portfolio, so as each program can develop a competence-based approach related to the translation, the selection of source texts to translate is not up to each teacher’s expert opinion, but to the fundamental features of the academic text selection. All this is in order to accomplish the objective of each class program and achieve the exit profile.