bluuebunny/crossref_metadata_2025 huggingface dataset:
ADHD medications use and risk of mortality and unintentional injuries: a population-based cohort study
Authors: Vasiliadis Helen-Maria , Lunghi Carlotta , Rahme Elham , Rochette Louis , Gignac Martin , Massamba Victoria , Diallo Fatoumata Binta , Fansi Alvine , Cortese Samuele , Lesage Alain
Published: February 2024

We assessed the association between the use of medications for attention-deficit/hyperactivity disorder (ADHD) and the risk of all-cause mortality and unintentional injuries leading to emergency department (ED) or hospital admission in individuals aged ≤24 years with ADHD. We conducted a population-based retrospective cohort study between 2000 and 2021 using Quebec health administrative data. Individuals were followed from the first ADHD diagnosis or ADHD medication claim until turning 25, death, or study end. Exposure was defined as mutually exclusive episodes of ADHD medication use and/or coverage under the public provincial drug plan (PDP): 1) covered and not treated with ADHD medication; 2) covered and treated with ADHD medication; and 3) not covered under the PDP. The risk of all-cause mortality and unintentional injuries associated with exposure episodes was estimated using multivariable survival analyses. The cohort included n = 217 192 individuals aged 1–24 years with a male to female ratio of close to 2:1. Compared to non-medication use, episodes of ADHD medication use, overall, were associated with reduced all-cause mortality (adjusted hazard ratio, aHR 0.61, 95% CI 0.48–0.76) and unintentional injury leading to ED (0.75, 0.74–0.77) or hospitalisation (0.71, 0.68–0.75). Episodes of stimulants were associated with a lower risk of all-cause mortality and reduced risk of unintentional injuries, while episodes with non-stimulants and with both stimulants and non-stimulants concomitantly were associated with reduced risk of unintentional injuries, but not of all-cause mortality. Although residual confounding cannot be excluded, stimulants may have a protective effect in terms of risk of all-cause mortality and both stimulants and non-stimulants for ADHD may reduce the risk of unintentional injuries. The findings of the current study should inform clinical decision making on the choice of starting a pharmacological treatment for ADHD, when a balance needs to be struck between expected benefits and possible risks.
µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice
Authors: Nisbett Khalin E. , Vendruscolo Leandro F. , Koob George F.
Published: February 2024

Mood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation. Previous studies have demonstrated that oxytocin reduced depression- and anxiety-like behavior in male and female mice, and opioid receptor activation reduced depression-like behavior. However, it remains unclear whether the endogenous opioid system interacts with the oxytocin system to facilitate emotion regulation in male and female mice. We hypothesized that opioid receptor blockade would inhibit the anxiolytic- and antidepressant-like effects of oxytocin. In this study, we systemically administered naloxone, a preferential μ−opioid receptor antagonist, and then intracerebroventricularly administered oxytocin. We then tested mice on the elevated zero maze and the tail suspension tests, respective tests of anxiety- and depression-like behavior. Contrary to our initial hypothesis, naloxone potentiated the anxiolytic-like, but not the antidepressant-like, effect of oxytocin. Using a selective μ−opioid receptor antagonist, D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2, and a selective κ−opioid receptor antagonist, norbinaltorphimine, we demonstrate that μ−opioid receptor blockade potentiated the anxiolytic-like effect of oxytocin, whereas κ−opioid receptor blockade inhibited the oxytocin-induced anxiolytic-like effects. The present results suggest that endogenous opioids can regulate the oxytocin system to modulate anxiety-like behavior. Potential clinical implications of these findings are discussed.
Epigenome-wide association study identifies neonatal DNA methylation associated with two-year attention problems in children born very preterm
Authors: Camerota Marie , Lester Barry M. , Castellanos Francisco Xavier , Carter Brian S. , Check Jennifer , Helderman Jennifer , Hofheimer Julie A. , McGowan Elisabeth C. , Neal Charles R. , Pastyrnak Steven L. , Smith Lynne M. , O’Shea Thomas Michael , Marsit Carmen J. , Everson Todd M.
Published: February 2024

Prior research has identified epigenetic predictors of attention problems in school-aged children but has not yet investigated these in young children, or children at elevated risk of attention problems due to preterm birth. The current study evaluated epigenome-wide associations between neonatal DNA methylation and attention problems at age 2 years in children born very preterm. Participants included 441 children from the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) Study, a multi-site study of infants born < 30 weeks gestational age. DNA methylation was measured from buccal swabs collected at NICU discharge using the Illumina MethylationEPIC Bead Array. Attention problems were assessed at 2 years of adjusted age using the attention problems subscale of the Child Behavior Checklist (CBCL). After adjustment for multiple testing, DNA methylation at 33 CpG sites was associated with child attention problems. Differentially methylated CpG sites were located in genes previously linked to physical and mental health, including several genes associated with ADHD in prior epigenome-wide and genome-wide association studies. Several CpG sites were located in genes previously linked to exposure to prenatal risk factors in the NOVI sample. Neonatal epigenetics measured at NICU discharge could be useful in identifying preterm children at risk for long-term attention problems and related psychiatric disorders, who could benefit from early prevention and intervention efforts.
Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis
Authors: Loginovic Pavel , Wang Feiyi , Li Jiang , Ferrat Lauric , Mirshahi Uyenlinh L. , Rao H. Shanker , Petzold Axel , Tyrrell Jessica , Green Harry D. , Weedon Michael N. , Ganna Andrea , Tuomi Tiinamaija , Carey David J. ,   UKBB Eye & Vision Consortium,   FinnGen,   Geisinger-Regeneron DiscovEHR Collaboration, Oram Richard A. , Braithwaite Tasanee
Published: February 2024

Optic neuritis (ON) is associated with numerous immune-mediated inflammatory diseases, but 50% patients are ultimately diagnosed with multiple sclerosis (MS). Differentiating MS-ON from non-MS-ON acutely is challenging but important; non-MS ON often requires urgent immunosuppression to preserve vision. Using data from the United Kingdom Biobank we showed that combining an MS-genetic risk score (GRS) with demographic risk factors (age, sex) significantly improved MS prediction in undifferentiated ON; one standard deviation of MS-GRS increased the Hazard of MS 1.3-fold (95% confidence interval 1.07–1.55, P < 0.01). Participants stratified into quartiles of predicted risk developed incident MS at rates varying from 4% (95%CI 0.5–7%, lowest risk quartile) to 41% (95%CI 33–49%, highest risk quartile). The model replicated across two cohorts (Geisinger, USA, and FinnGen, Finland). This study indicates that a combined model might enhance individual MS risk stratification, paving the way for precision-based ON treatment and earlier MS disease-modifying therapy.
Prediction of plasma ctDNA fraction and prognostic implications of liquid biopsy in advanced prostate cancer
Authors: Fonseca Nicolette M. , Maurice-Dror Corinne , Herberts Cameron , Tu Wilson , Fan William , Murtha Andrew J. , Kollmannsberger Catarina , Kwan Edmond M. , Parekh Karan , Schönlau Elena , Bernales Cecily Q. , Donnellan Gráinne , Ng Sarah W. S. , Sumiyoshi Takayuki , Vergidis Joanna , Noonan Krista , Finch Daygen L. , Zulfiqar Muhammad , Miller Stacy , Parimi Sunil , Lavoie Jean-Michel , Hardy Edward , Soleimani Maryam , Nappi Lucia , Eigl Bernhard J. , Kollmannsberger Christian , Taavitsainen Sinja , Nykter Matti , Tolmeijer Sofie H. , Boerrigter Emmy , Mehra Niven , van Erp Nielka P. , De Laere Bram , Lindberg Johan , Grönberg Henrik , Khalaf Daniel J. , Annala Matti , Chi Kim N. , Wyatt Alexander W.
Published: February 2024

No consensus strategies exist for prognosticating metastatic castration-resistant prostate cancer (mCRPC). Circulating tumor DNA fraction (ctDNA%) is increasingly reported by commercial and laboratory tests but its utility for risk stratification is unclear. Here, we intersect ctDNA%, treatment outcomes, and clinical characteristics across 738 plasma samples from 491 male mCRPC patients from two randomized multicentre phase II trials and a prospective province-wide blood biobanking program. ctDNA% correlates with serum and radiographic metrics of disease burden and is highest in patients with liver metastases. ctDNA% strongly predicts overall survival, progression-free survival, and treatment response independent of therapeutic context and outperformed established prognostic clinical factors. Recognizing that ctDNA-based biomarker genotyping is limited by low ctDNA% in some patients, we leverage the relationship between clinical prognostic factors and ctDNA% to develop a clinically-interpretable machine-learning tool that predicts whether a patient has sufficient ctDNA% for informative ctDNA genotyping (available online: https://www.ctDNA.org). Our results affirm ctDNA% as an actionable tool for patient risk stratification and provide a practical framework for optimized biomarker testing.
A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling
Authors: Kang Sun Woo Sophie , Cunningham Rory P. , Miller Colin B. , Brown Lauryn A. , Cultraro Constance M. , Harned Adam , Narayan Kedar , Hernandez Jonathan , Jenkins Lisa M. , Lobanov Alexei , Cam Maggie , Porat-Shliom Natalie
Published: February 2024

In the liver, mitochondria are exposed to different concentrations of nutrients due to their spatial positioning across the periportal and pericentral axis. How the mitochondria sense and integrate these signals to respond and maintain homeostasis is not known. Here, we combine intravital microscopy, spatial proteomics, and functional assessment to investigate mitochondrial heterogeneity in the context of liver zonation. We find that periportal and pericentral mitochondria are morphologically and functionally distinct; beta-oxidation is elevated in periportal regions, while lipid synthesis is predominant in the pericentral mitochondria. In addition, comparative phosphoproteomics reveals spatially distinct patterns of mitochondrial composition and potential regulation via phosphorylation. Acute pharmacological modulation of nutrient sensing through AMPK and mTOR shifts mitochondrial phenotypes in the periportal and pericentral regions, linking nutrient gradients across the lobule and mitochondrial heterogeneity. This study highlights the role of protein phosphorylation in mitochondrial structure, function, and overall homeostasis in hepatic metabolic zonation. These findings have important implications for liver physiology and disease.
Structure of the p53 degradation complex from HPV16
Authors: Wang John C. K. , Baddock Hannah T. , Mafi Amirhossein , Foe Ian T. , Bratkowski Matthew , Lin Ting-Yu , Jensvold Zena D. , Preciado López Magdalena , Stokoe David , Eaton Dan , Hao Qi , Nile Aaron H.
Published: February 2024

Human papillomavirus (HPV) is a significant contributor to the global cancer burden, and its carcinogenic activity is facilitated in part by the HPV early protein 6 (E6), which interacts with the E3-ligase E6AP, also known as UBE3A, to promote degradation of the tumor suppressor, p53. In this study, we present a single-particle cryoEM structure of the full-length E6AP protein in complex with HPV16 E6 (16E6) and p53, determined at a resolution of ~3.3 Å. Our structure reveals extensive protein-protein interactions between 16E6 and E6AP, explaining their picomolar binding affinity. These findings shed light on the molecular basis of the ternary complex, which has been pursued as a potential therapeutic target for HPV-driven cervical, anal, and oropharyngeal cancers over the last two decades. Understanding the structural and mechanistic underpinnings of this complex is crucial for developing effective therapies to combat HPV-induced cancers. Our findings may help to explain why previous attempts to disrupt this complex have failed to generate therapeutic modalities and suggest that current strategies should be reevaluated.
Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment
Authors: Köck Zoe , Schnelle Kilian , Persechino Margherita , Umbach Simon , Schihada Hannes , Januliene Dovile , Parey Kristian , Pockes Steffen , Kolb Peter , Dötsch Volker , Möller Arne , Hilger Daniel , Bernhard Frank
Published: February 2024

Here we describe the cryo-electron microscopy structure of the human histamine 2 receptor (H2R) in an active conformation with bound histamine and in complex with Gs heterotrimeric protein at an overall resolution of 3.4 Å. The complex was generated by cotranslational insertion of the receptor into preformed nanodisc membranes using cell-free synthesis in E. coli lysates. Structural comparison with the inactive conformation of H2R and the inactive and Gq-coupled active state of H1R together with structure-guided functional experiments reveal molecular insights into the specificity of ligand binding and G protein coupling for this receptor family. We demonstrate lipid-modulated folding of cell-free synthesized H2R, its agonist-dependent internalization and its interaction with endogenously synthesized H1R and H2R in HEK293 cells by applying a recently developed nanotransfer technique.
Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover
Authors: Hvorecny Kelli L. , Sladewski Thomas E. , De La Cruz Enrique M. , Kollman Justin M. , Heaslip Aoife T.
Published: February 2024

The cytoskeletal protein actin plays a critical role in the pathogenicity of the intracellular parasite, Toxoplasma gondii, mediating invasion and egress, cargo transport, and organelle inheritance. Advances in live cell imaging have revealed extensive filamentous actin networks in the Apicomplexan parasite, but there are conflicting data regarding the biochemical and biophysical properties of Toxoplasma actin. Here, we imaged the in vitro assembly of individual Toxoplasma actin filaments in real time, showing that native, unstabilized filaments grow tens of microns in length. Unlike skeletal muscle actin, Toxoplasma filaments intrinsically undergo rapid treadmilling due to a high critical concentration, fast monomer dissociation, and rapid nucleotide exchange. Cryo-EM structures of jasplakinolide-stabilized and native (i.e. unstabilized) filaments show an architecture like skeletal actin, with differences in assembly contacts in the D-loop that explain the dynamic nature of the filament, likely a conserved feature of Apicomplexan actin. This work demonstrates that evolutionary changes at assembly interfaces can tune the dynamic properties of actin filaments without disrupting their conserved structure.
Epitaxy of wafer-scale single-crystal MoS2 monolayer via buffer layer control
Authors: Li Lu , Wang Qinqin , Wu Fanfan , Xu Qiaoling , Tian Jinpeng , Huang Zhiheng , Wang Qinghe , Zhao Xuan , Zhang Qinghua , Fan Qinkai , Li Xiuzhen , Peng Yalin , Zhang Yangkun , Ji Kunshan , Zhi Aomiao , Sun Huacong , Zhu Mingtong , Zhu Jundong , Lu Nianpeng , Lu Ying , Wang Shuopei , Bai Xuedong , Xu Yang , Yang Wei , Li Na , Shi Dongxia , Xian Lede , Liu Kaihui , Du Luojun , Zhang Guangyu
Published: February 2024

Monolayer molybdenum disulfide (MoS2), an emergent two-dimensional (2D) semiconductor, holds great promise for transcending the fundamental limits of silicon electronics and continue the downscaling of field-effect transistors. To realize its full potential and high-end applications, controlled synthesis of wafer-scale monolayer MoS2 single crystals on general commercial substrates is highly desired yet challenging. Here, we demonstrate the successful epitaxial growth of 2-inch single-crystal MoS2 monolayers on industry-compatible substrates of c-plane sapphire by engineering the formation of a specific interfacial reconstructed layer through the S/MoO3 precursor ratio control. The unidirectional alignment and seamless stitching of MoS2 domains across the entire wafer are demonstrated through cross-dimensional characterizations ranging from atomic- to centimeter-scale. The epitaxial monolayer MoS2 single crystal shows good wafer-scale uniformity and state-of-the-art quality, as evidenced from the ~100% phonon circular dichroism, exciton valley polarization of ~70%, room-temperature mobility of ~140 cm2v−1s−1, and on/off ratio of ~109. Our work provides a simple strategy to produce wafer-scale single-crystal 2D semiconductors on commercial insulator substrates, paving the way towards the further extension of Moore’s law and industrial applications of 2D electronic circuits.
Continuous strain tuning of oxygen evolution catalysts with anisotropic thermal expansion
Authors: Du Yu , Xie Fakang , Lu Mengfei , Lv Rongxian , Liu Wangxi , Yan Yuandong , Yan Shicheng , Zou Zhigang
Published: February 2024

Compressive strain, downshifting the d-band center of transition metal oxides, is an effective way to accelerate the sluggish kinetics of oxygen evolution reaction (OER) for water electrolysis. Here, we find that anisotropic thermal expansion can produce compressive strains of the IrO6 octahedron in Sr2IrO4 catalyst, thus downshifting its d-band center. Different from the previous strategies to create constant strains in the crystals, the thermal-triggered compressive strains can be real-timely tuned by varying temperature. As a result of the thermal strain accelerating OER kinetics, the Sr2IrO4 exhibits the nonlinear lnjo - T−1 (jo, exchange current density; T, absolute temperature) Arrhenius relationship, resulting from the thermally induced low-barrier electron transfer in the presence of thermal compressive strains. Our results verify that the thermal field can be utilized to manipulate the electronic states of Sr2IrO4 via thermal compressive strains downshifting the d-band center, significantly accelerating the OER kinetics, beyond the traditional thermal diffusion effects.
Low pressure reversibly driving colossal barocaloric effect in two-dimensional vdW alkylammonium halides
Authors: Gao Yi-Hong , Wang Dong-Hui , Hu Feng-Xia , Huang Qing-Zhen , Song You-Ting , Yuan Shuai-Kang , Tian Zheng-Ying , Wang Bing-Jie , Yu Zi-Bing , Zhou Hou-Bo , Kan Yue , Lin Yuan , Wang Jing , Li Yun-liang , Liu Ying , Chen Yun-Zhong , Sun Ji-Rong , Zhao Tong-Yun , Shen Bao-Gen
Published: February 2024

Plastic crystals as barocaloric materials exhibit the large entropy change rivalling freon, however, the limited pressure-sensitivity and large hysteresis of phase transition hinder the colossal barocaloric effect accomplished reversibly at low pressure. Here we report reversible colossal barocaloric effect at low pressure in two-dimensional van-der-Waals alkylammonium halides. Via introducing long carbon chains in ammonium halide plastic crystals, two-dimensional structure forms in (CH3–(CH2)n-1)2NH2X (X: halogen element) with weak interlayer van-der-Waals force, which dictates interlayer expansion as large as 13% and consequently volume change as much as 12% during phase transition. Such anisotropic expansion provides sufficient space for carbon chains to undergo dramatic conformation disordering, which induces colossal entropy change with large pressure-sensitivity and small hysteresis. The record reversible colossal barocaloric effect with entropy change ΔSr ~ 400 J kg−1 K−1 at 0.08 GPa and adiabatic temperature change ΔTr ~ 11 K at 0.1 GPa highlights the design of novel barocaloric materials by engineering the dimensionality of plastic crystals.
Wide-field mid-infrared hyperspectral imaging beyond video rate
Authors: Fang Jianan , Huang Kun , Qin Ruiyang , Liang Yan , Wu E , Yan Ming , Zeng Heping
Published: February 2024

Mid-infrared hyperspectral imaging has become an indispensable tool to spatially resolve chemical information in a wide variety of samples. However, acquiring three-dimensional data cubes is typically time-consuming due to the limited speed of raster scanning or wavelength tuning, which impedes real-time visualization with high spatial definition across broad spectral bands. Here, we devise and implement a high-speed, wide-field mid-infrared hyperspectral imaging system relying on broadband parametric upconversion of high-brightness supercontinuum illumination at the Fourier plane. The upconverted replica is spectrally decomposed by a rapid acousto-optic tunable filter, which records high-definition monochromatic images at a frame rate of 10 kHz based on a megapixel silicon camera. Consequently, the hyperspectral imager allows us to acquire 100 spectral bands over 2600-4085 cm−1 in 10 ms, corresponding to a refreshing rate of 100 Hz. Moreover, the angular dependence of phase matching in the image upconversion is leveraged to realize snapshot operation with spatial multiplexing for multiple spectral channels, which may further boost the spectral imaging rate. The high acquisition rate, wide-field operation, and broadband spectral coverage could open new possibilities for high-throughput characterization of transient processes in material and life sciences.
A perspective on the evidence for glymphatic obstruction in spaceflight associated neuro-ocular syndrome and fatigue
Authors: Bateman Grant Alexander , Bateman Alexander Robert
Published: February 2024

Spaceflight associated neuro-ocular syndrome (SANS) alters the vision of astronauts during long-duration spaceflights. Previously, the current authors have discussed the similarities and differences between SANS and idiopathic intracranial hypertension to try to elucidate a possible pathophysiology. Recently, a theory has been advanced that SANS may occur secondary to failure of the glymphatic system caused by venous dilatation within the brain and optic nerves. There is recent evidence to suggest glymphatic obstruction occurs in childhood hydrocephalus, multiple sclerosis and syringomyelia due to venous outflow dilatation similar to that proposed in SANS. The purpose of the current paper is to discuss the similarities and differences between the known CSF and venous pathophysiology in SANS with these other terrestrial diseases, to see if they can shed any further light on the underlying cause of this microgravity-induced disease.
Supramolecular polymers form tactoids through liquid–liquid phase separation
Authors: Fu Hailin , Huang Jingyi , van der Tol Joost J. B. , Su Lu , Wang Yuyang , Dey Swayandipta , Zijlstra Peter , Fytas George , Vantomme Ghislaine , Dankers Patricia Y. W. , Meijer E. W.
Published: February 2024

Liquid–liquid phase separation (LLPS) of biopolymers has recently been shown to play a central role in the formation of membraneless organelles with a multitude of biological functions1–3. The interplay between LLPS and macromolecular condensation is part of continuing studies4,5. Synthetic supramolecular polymers are the non-covalent equivalent of macromolecules but they are not reported to undergo LLPS yet. Here we show that continuously growing fibrils, obtained from supramolecular polymerizations of synthetic components, are responsible for phase separation into highly anisotropic aqueous liquid droplets (tactoids) by means of an entropy-driven pathway. The crowding environment, regulated by dextran concentration, affects not only the kinetics of supramolecular polymerizations but also the properties of LLPS, including phase-separation kinetics, morphology, internal order, fluidity and mechanical properties of the final tactoids. In addition, substrate–liquid and liquid–liquid interfaces proved capable of accelerating LLPS of supramolecular polymers, allowing the generation of a myriad of three-dimensional-ordered structures, including highly ordered arrays of micrometre-long tactoids at surfaces. The generality and many possibilities of supramolecular polymerizations to control emerging morphologies are demonstrated with several supramolecular polymers, opening up a new field of matter ranging from highly structured aqueous solutions by means of stabilized LLPS to nanoscopic soft matter.
Feasibility of online managing cancer and living meaningfully (CALM) in Chinese patients with metastatic breast cancer: a pilot randomized control trial
Authors: Zhang Yening , Pang Ying , He Yi , You Miaoning , Tang Lili
Published: February 2024

Metastatic breast cancer could cause various psychological symptoms. Managing Cancer and Living Meaningfully (CALM) is a brief, manualized psychotherapy that has been validated for advanced cancer patients. We conducted a pilot randomized control trial (RCT) to verify the feasibility and preliminary efficacy of CALM therapy in this population. Patients who met the inclusion criteria were randomly assigned into CALM or Wait-list Control (WLC) groups. Patients in the CALM group received CALM therapy and usual care; patients in WLC group first received usual care and then underwent CALM therapy after completing all assessments. All patients were asked to complete three assessments: T0(baseline), T1(3 months), and T2(6 months). The primary outcomes was death anxiety; other outcomes were depression, distress, suicide ideation, attachment security, spiritual well-being and quality of life at the end of life. Analysis of Covariance (ANCOVA) and t-test were used for statistics analysis. Thirty-six patients were randomly assigned to either of the two groups, with 34 patients completing the three assessments. At six months, we found significant between group differences in suicide ideation, distress, and life completion between the CALM and WLC groups. At T2, patients in CALM group reported lower levels of depression (F = 5.016, p = 0.033, partial η2 = 0.143), distress (F = 7.969, p = 0.010, partial η2 = 0.257), attachment avoidance (F = 4.407, p = 0.044, partial η2 = 0.128), and better sense of life completion (F = 5.493, p = 0.026, partial η2 = 0.155) than patients in the WLC group. Compared with results of the T0 assessments, we found significant differences in socres for depression (T2&T0, t = − 2.689, p = 0.011, Cohen’s d = 0.940) and distress (T2&T0, t = − 2.453, p = 0.022, Cohen’s d = 0.965) between the two groups. CALM therapy was well received by the study population, and CALM therapy can reduce depression, distress, attachment avoidance while improving quality of life in Chinese metastatic breast cancer patients. A Phase III RCT was recommended to verify the impact of CALM therapy on psychological burden and survival in this population.

Trial registration: This study is part of the “Preliminary application study for Managing Cancer and Living Meaningfully (CALM) therapy in Chinese advanced cancer patients” clinical trial, with the Trial Registration Number of ChiCTR1900023129 (13/05/2019) in the Chinese Clinical Trial Registry (ChiCTR) website. (https://www.chictr.org.cn/index.html).
Establishing forward mixing model to mass transfer overview in multi-impeller agitated column for rare Earth extraction process
Authors: Torkaman Rezvan , Rovais Mohammad Reza Aboudzadeh , Asadollahzadeh Mehdi , Torab-Mostaedi Meisam , Saremi Mojtaba
Published: February 2024

The current study develops comprehensive mass transfer models to optimize the rare earth extraction. A plug flow, axial dispersion, backflow, forward mixing-based mass transfer model was created and solved numerically using the fitting technique. The investigated process is a multi-impeller agitated column designed to provide proper contact between organic and aqueous phases to extract rare-earth ions. Taking Sm(III)–Gd(III) separation as an application case, extraction efficiency in the agitation speed of 200 rpm was obtained equal to 95.14%, 76.67% by this column for Gd(III), and Sm(III) ions, respectively. The model's findings were compared with experimental data, and a significant agreement was achieved with the forward mixing model. The results indicated that the high agitation speed is beneficial to increasing the interfacial area while reducing the mass-transfer coefficient. On the contrary, the circulation within the larger droplet improves the transfer of mass, albeit at the expense of reducing the interfacial area. The results showed that the drop size distribution is a crucial factor as the droplet sizes significantly affect the droplet mass transfer. The mathematical models’ values of Ec for mass transfer parameters showed that the operational variables significantly affect the mass transfer rate and can cause deviations from the ideal flow path. A reasonable and appropriate estimation of the organic-side volumetric overall mass transfer coefficient was provided, which can be applied to this contactor’s design and scale-up.
Instrumental activities of daily living in older patients with metastatic prostate cancer: results from the meet-URO network ADHERE prospective study
Authors: Fratino Lucia , Polesel Jerry , Giunta Emilio Francesco , Maruzzo Marco , Buti Sebastiano , Hassan Mona Ali , Basso Umberto , Rebuzzi Sara Elena , De Giorgi Ugo , Cinausero Marika , Lipari Helga , Gamba Teresa , Bimbatti Davide , Dri Arianna , Ermacora Paola , Vignani Francesca , Fornarini Giuseppe , Rescigno Pasquale , Banna Giuseppe Luigi
Published: February 2024

Instrumental activities of daily living (IADL) are significant health indicators closely related to executive functions and able to detect mild cognitive impairment. A decline in IADL usually precedes ADL limitation, including taking medications, and may therefore predict a cognitive decline. We aimed to investigate the association of patients’ IADL score with other clinical factors, with a particular focus on the presence of a caregiver, and the impact on adherence to androgen receptor pathway inhibitors (ARPIs) and survival outcomes within the Meet-URO 5—ADHERE study. It was a large prospective multicentre observational cohort study monitoring adherence to ARPIs in 234 metastatic castrate-resistant PC (mCRPC) patients aged ≥ 70. We observed an association between impaired IADL and lower geriatric G8 scores (p < 0.01), and lower adherence to ARPIs whether assessed by pill counting (p = 0.01) or self-reported by the patient himself (p = 0.03). The combination of an IADL < 6 and the absence of a caregiver resulted in a significantly high risk of non-adherence to the ARPIs at the multivariable analysis (HR 9.23, 95% confidence interval 2.28–37.43, p = 0.01). IADL alongside the geriatric G8 scales represent essential tools to identify frail and less auto-sufficient patients who are extremely vulnerable particularly if not supported by a caregiver and have the highest risk of nonadherence to ARPIs.
Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei Province
Authors: Liu Hao , Li Jun , Zhu Shijie , Zhang Xupeng , Zhang Faxue , Zhang Xiaowei , Zhao Gaichan , Zhu Wei , Zhou Fang
Published: February 2024

Liver cancer, a chronic non-communicable disease, represents a serious public health problem. Long-term trends in the burden of liver cancer disease are heterogeneous across regions. Incidence and mortality of liver cancer, based on the Global Burden of Disease, were collected from the Chinese Centre for Disease Control and Prevention. Age–period–cohort model was utilized to reveal the secular trends and estimate the age, period and cohort effects on primary liver cancer due to specific etiologies. Both the age-standardized incidence and mortality rate of liver cancer in Hubei province were on the rise, although there were discrepancies between gender groups. From age–period–cohort analysis, both incidence and mortality of liver cancer due to Hepatitis B virus were the highest in all age groups. The incidence of all liver cancer groups increased with time period in males, while this upward trend was observed in females only in liver cancer due to alcohol use group. Cohort effects indicated the disease burden of liver cancer decreased with birth cohorts. Local drifts showed that the incidence of liver cancer due to specific etiologies was increasing in the age group of males between 40 and 75 years old. The impact of an aging population will continue in Hubei Province. the disease burden of liver cancer will continue to increase, and personalized prevention policies must be adopted to address these changes.
Difference in differences analysis evaluates the effects of the badger control policy on bovine tuberculosis in England
Authors: Birch Colin P. D. , Bakrania Mayur , Prosser Alison , Brown Dan , Withenshaw Susan M. , Downs Sara H.
Published: February 2024

Persistent tuberculosis (TB) in cattle populations in England has been associated with an exchange of infection with badgers (Meles meles). A badger control policy (BCP) commenced in 2013. Its aim was to decrease TB incidence in cattle by reducing the badger population available to provide a wildlife reservoir for bovine TB. Monitoring data from 52 BCP intervention areas 200–1600 km2 in size, starting over several years, were used to estimate the change in TB incidence rate in cattle herds, which was associated with time since the start of the BCP in each area. A difference in differences analysis addressed the non-random selection and starting sequence of the areas. The herd incidence rate of TB reduced by 56% (95% Confidence Interval 41–69%) up to the fourth year of BCP interventions, with the largest drops in the second and third years. There was insufficient evidence to judge whether the incidence rate reduced further beyond 4 years. These estimates are the most precise for the timing of declines in cattle TB associated with interventions primarily targeting badgers. They are within the range of previous estimates from England and Ireland. This analysis indicates the importance of reducing transmission from badgers to reduce the incidence of TB in cattle, noting that vaccination of badgers, fertility control and on farm biosecurity may also achieve this effect.
A rule-based energy management system for hybrid renewable energy sources with battery bank optimized by genetic algorithm optimization
Authors: Jamal Saif , Pasupuleti Jagadeesh , Ekanayake Janaka
Published: February 2024

A Nanogrid (NG) model is described as a power distribution system that integrates Hybrid Renewable Energy Sources (HRESs) and Energy Storage Systems (ESSs) into the primary grid. However, this process is affected by several factors, like load variability, market pricing, and the intermittent nature of Wind Turbines (WTs) and Photovoltaic (PV) systems. Hence, other researchers in the past have used a few optimization-based processes to improve the development of Energy Management Systems (EMSs) and ESSs, which further enhanced the operational performance of NGs. It was seen that EMS acts as the distributed energy source in the NG setup and assists in power generation, usage, dissemination, and differential pricing. Hence this study employed the MATLAB Simulink software for modelling the grid-connected NG that included HRES; such as wind and PV; in addition to 3 Battery Storage Devices (BSDs) to design an effective EMS for the NG system and decrease its overall costs. For this purpose, a Rule-Based EMS (RB-EMS) that employs State Flow (SF) to guarantee a safe and reliable operating power flow to the NG has been developed. In addition to that, a Genetic Algorithm (GA)-based optimization system and Simulated Annealing optimization Algorithm (SAA) were proposed to determine an economical solution for decreasing the cost of the NG system depending on its operational constraints. Lastly, comparison about the cost between RB-EMS, GA and SAA has been presented. According to the simulation results, the proposed GA displayed an economical performance since it could achieve a 40% cost saving whereas the SAA system showed a 19.3% cost saving compared to the RB-EMS. It can be concluded from the findings that the GA-based optimization technique was very cost-effective displays many important features, like rapid convergence, simple design, and very few controlling factors.
Comparative study of some non-Newtonian nanofluid models across stretching sheet: a case of linear radiation and activation energy effects
Authors: Shah Syed Asif Ali , Idrees Muhammad , Bariq Abdul , Ahmad Bilal , Ali Bagh , Ragab Adham E. , Az-Zo’bi Emad A.
Published: February 2024

The use of renewable energy sources is leading the charge to solve the world’s energy problems, and non-Newtonian nanofluid dynamics play a significant role in applications such as expanding solar sheets, which are examined in this paper, along with the impacts of activation energy and solar radiation. We solve physical flow issues using partial differential equations and models like Casson, Williamson, and Prandtl. To get numerical solutions, we first apply a transformation to make these equations ordinary differential equations, and then we use the MATLAB-integrated bvp4c methodology. Through the examination of dimensionless velocity, concentration, and temperature functions under varied parameters, our work explores the physical properties of nanofluids. In addition to numerical and tabular studies of the skin friction coefficient, Sherwood number, and local Nusselt number, important components of the flow field are graphically shown and analyzed. Consistent with previous research, this work adds important new information to the continuing conversation in this area. Through the examination of dimensionless velocity, concentration, and temperature functions under varied parameters, our work explores the physical properties of nanofluids. Comparing the Casson nanofluid to the Williamson and Prandtl nanofluids, it is found that the former has a lower velocity. Compared to Casson and Williamson nanofluid, Prandtl nanofluid advanced in heat flux more quickly. The transfer of heat rates are $$25.87\%$$

25.87
%

, $$33.61\%$$

33.61
%

and $$40.52\%$$

40.52
%

at $$Rd =0.5, Rd=1.0$$

R
d
=
0.5
,
R
d
=
1.0

, and $$Rd=1.5$$

R
d
=
1.5

, respectively. The heat transfer rate is increased by $$6.91\%$$

6.91
%

as the value of Rd rises from 1.0 to 1.5. This study is further strengthened by a comparative analysis with previous research, which is complemented by an extensive table of comparisons for a full evaluation.
Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility
Authors: Seo Sean H. B. , Wells Cameron I. , Dickson Tully , Rowbotham David , Gharibans Armen , Calder Stefan , Bissett Ian , O’Grady Greg , Erickson Jonathan C.
Published: February 2024

Abnormal cyclic motor pattern (CMP) activity is implicated in colonic dysfunction, but the only tool to evaluate CMP activity, high-resolution colonic manometry (HRCM), remains expensive and not widely accessible. This study aimed to validate body surface colonic mapping (BSCM) through direct correlation with HRCM. Synchronous meal-test recordings were performed in asymptomatic participants with intact colons. A signal processing method for BSCM was developed to detect CMPs. Quantitative temporal analysis was performed comparing the meal responses and motility indices (MI). Spatial heat maps were also compared. Post-study questionnaires evaluated participants’ preference and comfort/distress experienced from either test. 11 participants were recruited and 7 had successful synchronous recordings (5 females/2 males; median age: 50 years [range 38–63]). The best-correlating MI temporal analyses achieved a high degree of agreement (median Pearson correlation coefficient (Rp) value: 0.69; range 0.47–0.77). HRCM and BSCM meal response start and end times (Rp = 0.998 and 0.83; both p < 0.05) and durations (Rp = 0.85; p = 0.03) were similar. Heat maps demonstrated good spatial agreement. BSCM is the first non-invasive method to be validated by demonstrating a direct spatio-temporal correlation to manometry in evaluating colonic motility.
Automatic assessment of infant carrying and holding using at-home wearable recordings
Authors: Airaksinen Manu , Vaaras Einari , Haataja Leena , Räsänen Okko , Vanhatalo Sampsa
Published: February 2024

Assessing infant carrying and holding (C/H), or physical infant-caregiver interaction, is important for a wide range of contexts in development research. An automated detection and quantification of infant C/H is particularly needed in long term at-home studies where development of infants’ neurobehavior is measured using wearable devices. Here, we first developed a phenomenological categorization for physical infant-caregiver interactions to support five different definitions of C/H behaviors. Then, we trained and assessed deep learning-based classifiers for their automatic detection from multi-sensor wearable recordings that were originally used for mobile assessment of infants’ motor development. Our results show that an automated C/H detection is feasible at few-second temporal accuracy. With the best C/H definition, the automated detector shows 96% accuracy and 0.56 kappa, which is slightly less than the video-based inter-rater agreement between trained human experts (98% accuracy, 0.77 kappa). The classifier performance varies with C/H definition reflecting the extent to which infants’ movements are present in each C/H variant. A systematic benchmarking experiment shows that the widely used actigraphy-based method ignores the normally occurring C/H behaviors. Finally, we show proof-of-concept for the utility of the novel classifier in studying C/H behavior across infant development. Particularly, we show that matching the C/H detections to individuals’ gross motor ability discloses novel insights to infant-parent interaction.
Effects of ophidiomycosis on movement, survival, and reproduction of eastern foxsnakes (Pantherophis vulpinus)
Authors: Dillon Rachel M. , Paterson James E. , Manorome Pilar , Ritchie Kyle , Shirose Leonard , Slavik Emily , Davy Christina M.
Published: February 2024

Ophidiomycosis (snake fungal disease) is caused by the fungal pathogen Ophidiomyces ophidiicola, which causes dermal lesions, occasional systemic infections, and in some cases, mortality. To better understand potential conservation implications of ophidiomycosis (i.e., population-level effects), we investigated its impacts on individual fitness in a population of endangered eastern foxsnakes (Pantherophis vulpinus). We tracked 38 foxsnakes over 6 years and quantified body condition, movement patterns, oviposition rates, and survival. Body condition, distance travelled, and oviposition rates were similar between snakes with and without ophidiomycosis. Interestingly, snakes that tested positive for the pathogen travelled farther, suggesting that movement through a greater diversity of habitats increases risk of exposure. Ophidiomycosis did not negatively affect survival, and most apparently infected snakes persisted in a manner comparable to snakes without ophidiomycosis. Only one mortality was directly attributed to ophidiomycosis, although infected snakes were overrepresented in a sample of snakes killed by predators. Overall, our results suggest that ophidiomycosis may have sublethal effects on eastern foxsnakes, but do not suggest direct effects on survival, ovipositioning, or viability of the study population.
A multi-scale lifecycle and technoeconomic framework for higher education fleet electrification
Authors: Juang Jason , Williams Wyatt Green , Ramshankar Arjun T. , Schmidt John , Xuan Kendrick , Bozeman Joe F.
Published: February 2024

Transportation accounts for one-quarter of all energy related greenhouse gas emissions. As it pertains to transport electrification, higher education institutions—such as universities—can model solutions that affect broader society. Despite this, higher education’s role in fleet electrification adoption has been understudied. We, therefore, modeled an archetypical higher education institution to analyze the carbon and economic payback periods of three electrification scenarios (Business-as-Usual, Targeted Electrification, and Full Electrification) using a cradle-to-grave lifecycle and technoeconomic approach. Given the archetypical higher education institution fleet of 368 vehicles, results show an economic ratio plateau point of about 8 years at 20 fuel-based cars replaced by electric vehicles and a carbon payback period peak of roughly 10 months at 50 fuel-based cars replaced. We then performed a multi-scalar analysis by leveraging implementation theory. We find that higher education institutions that adhere to the tenets of implementation theory are poised to be pro-environmental change agents in many regions and countries. The methods and findings herein can be adapted to other institutions, regardless of fleet size, and can bolster relevant decision-making outcomes now.
Study on the macro–micro evolution of compaction characteristics of coal gangue with different grain sizes under side-limit compression conditions
Authors: Liu Zhenzhi , Liu Ping , Lu Zhen , Li Jian , Luo Chang
Published: February 2024

Currently the main method of mine solid waste disposal and utilization is to apply gangue to underground filling. For the grading characteristics of coal gangue in the hollow zone in underground filling, the state of pressure and the mechanical properties of coal gangue filling materials under different particle sizes. In this paper, through laboratory tests and numerical simulations, the bearing characteristics and deformation damage of gangue are deeply investigated and analyzed from both macroscopic and microscopic perspectives. The results of the study show that when the axial pressure reaches a certain threshold, the strain increases accordingly with the increase in grain size. Under the axial pressure condition of 15MPa, the bearing capacity of gangue with different grain sizes under the lateral pressure of steel cylinder showed obvious positive correlation. In the software PFC3D simulation, as the particle size of gangue particles increases, it has a significant effect on the natural stacking porosity of the specimen, and gangue particles are more prone to force chain instability and failure. Mixed particle size gangue can significantly reduce the natural accumulation porosity of the specimen, thus improving its overall stability. Significant displacement triangles existed in the top and lateral directions of the B1 (0–5 mm), B2 (5–10 mm), and B5 (0–20 mm) specimens under the same circumferential pressure conditions. The results of the study are of great significance for further selection of reasonable gangue gradation and determination of its mechanical properties.
Partial Ly$$\alpha$$ thermalization in an analytic nonlinear diffusion model
Authors: Wolschin Georg
Published: February 2024

During recombination, the cosmic background radiation is disturbed, in particular, by Lyman-alpha emissions from neutral hydrogen. It is proposed to account for the subsequent time-dependent partial thermalization of the Ly$$\alpha$$
α
energy content in an analytically solvable nonlinear diffusion model. The amplitude of the partially thermalized and redshifted Ly$$\alpha$$
α
line is found to be too low to be visible in the cosmic microwave spectrum, in accordance with previous numerical models and Planck observations.