bluuebunny/crossref_metadata_2025 huggingface dataset:
Interstitial lung disease with and without progressive fibrosing phenotype in patients with idiopathic inflammatory myopathies: data from a large multicentric cohort
Authors: Zanatta Elisabetta , Cocconcelli Elisabetta , Castelli Gioele , Giraudo Chiara , Fraia Anna Sara , De Zorzi Elena , Gatto Mariele , Ienna Luana , Treppo Elena , Malandrino Danilo , Cereser Lorenzo , Emmi Giacomo , Giannelli Federico , Bellani Serena , Martini Andrea , Moccaldi Beatrice , Ghirardello Anna , Avouac Jérôme , Quartuccio Luca , Allanore Yannick , Doria Andrea , Spagnolo Paolo , Balestro Elisabetta , Iaccarino Luca
Published: August 2023

Objectives

Patients with connective tissue diseases can develop interstitial lung disease (ILD), leading to a progressive fibrosing ILD (PF-ILD) phenotype in some cases. We aimed to investigate the occurrence of PF-ILD in idiopathic inflammatory myopathies (IIMs), and factors potentially predicting this phenotype. Secondary aims were to assess the radiological pattern and factors associated with IIMs-ILD.

Methods

Patients with IIMs from our multicentric prospective cohort were retrospectively evaluated. Data were recorded at IIMs and ILD diagnosis, and during follow-up. Patients with ILD were classified according to the predominant high-resolution CT (HRCT) pattern: non-specific interstitial pneumonia (NSIP), usual interstitial pneumonia (UIP) and organising pneumonia (OP). PF-ILD was defined according to the 2022 American Thoracic Society (ATS), European Respiratory Society (ERS), Japanese Respiratory Society (JRS) and Latin American Thoracic Society (ALAT) guidelines. Univariate and multivariate analyses were performed to identify factors associated to ILD and to PF-ILD.

Results

Of 253 patients with IIMs, 125 (49%) had ILD: 99 (78%) at IIMs diagnosis and 26 (22%) during follow-up (21/26 within 5 years). Multivariate analysis identified anti-Jo-1, anti-MDA5, anti-Ro52, high score on manual muscle test, mechanic’s hands and Raynaud’s phenomenon as independently associated with ILD. The predominant HRCT pattern was NSIP (50% of patients), followed by UIP (28%) and OP (22%). At 1-year follow-up, PF-ILD occurred in 18% of IIMs-ILD. PF-ILD was predicted by anti-MDA5, heliotropic rash, xerostomia and xerophthalmia at univariate but not at multivariate analysis.

Conclusion

Patients with IIM should be carefully screened for ILD at IIMs diagnosis and yearly during follow-up. All patients with IIMs-ILD should be carefully monitored to capture ILD progression since a consistent proportion of them are expected to develop PF-ILD.
A Jeap-BiLSTM Neural Network for Action Recognition
Authors: Tan Lunzheng , Liu Yanfei , Xia Limin , Chen Shangsheng , Zhou Zhanben
Published: August 2023

Human action recognition in videos is an important task in computer vision with applications in fields such as surveillance, human–computer interaction, and sports analysis. However, it is a challenging task due to the complex background changes and redundancy of long-term video information. In this paper, we propose a novel bi-directional long short-term memory method with attention pooling based on joint motion and difference entropy (JEAP-BiLSTM) to address these challenges. To obtain discriminative features, we introduce a joint entropy map that measures both the entropy of motion and the entropy of change. The Bi-LSTM method is then applied to capture visual and temporal associations in both forward and backward directions, enabling efficient capture of long-term temporal correlation. Furthermore, attention pooling is used to highlight the region of interest and to mitigate the effects of background changes in video information. Experiments on the UCF101 and HMDB51 datasets demonstrate that the proposed JEAP-BiLSTM method achieves recognition rates of 96.4% and 75.2%, respectively, outperforming existing methods. Our proposed method makes significant contributions to the field of human action recognition by effectively capturing both spatial and temporal patterns in videos, addressing background changes, and achieving state-of-the-art performance.
Research on Printmaking Image Classification and Creation Based on Convolutional Neural Network
Authors: Pan Kai , Chi Hongyan
Published: August 2023

As an important form of expression in modern civilization art, printmaking has a rich variety of types and a prominent sense of artistic hierarchy. Therefore, printmaking is highly favored around the world due to its unique artistic characteristics. Classifying print types through image feature elements will improve people’s understanding of print creation. Convolutional neural networks (CNNs) have good application effects in the field of image classification, so CNN is used for printmaking analysis. Considering that the classification effect of the traditional convolutional neural image classification model is easily affected by the activation function, the T-ReLU activation function is introduced. By utilizing adjustable parameters to enhance the soft saturation characteristics of the model and avoid gradient vanishing, a T-ReLU convolutional model is constructed. A better convolutional image classification model is proposed based on the T-ReLU convolutional model, taking into account the issue of subpar multi-level feature fusion in deep convolutional image classification models. Utilize normalization to analyze visual input, an eleven-layer convolutional network with residual units in the convolutional layer, and cascading thinking to fuse convolutional network defects. The performance test results showed that in the data test of different styles of artificial prints, the GT-ReLU model can obtain the best image classification accuracy, and the image classification accuracy rate is 0.978. The GT-ReLU model maintains a classification accuracy above 94.4% in the multi-dataset test classification performance test, which is higher than that of other image classification models. For the use of visual processing technology in the field of classifying prints, the research content provides good reference value.
Exploring the Barriers and Potential Opportunities of Technology Integration in Community-Based Social Service Organizations
Authors: Anuyah Oghenemaro , Conrado Ann-Marie , Carlson Clinton , Gilbride Hope , Metoyer Ronald
Published: August 2023

Community-based social service organizations often face multifaceted challenges, including limited resources, inadequate staffing, funding constraints, and high demand for their services. These challenges are often exacerbated when serving vulnerable communities with complex social needs. Despite these difficulties, technology holds the potential to help bridge the service gap, enabling these organizations to respond more effectively to the diverse needs of their communities. In our work, we conducted 21 semi-structured interviews with representatives from different community-based social service organizations in a mid-sized city in Northern Indiana. This city struggles with high rates of poverty and homelessness in several of its neighborhoods. Our findings revealed that although these organizations faced numerous technological challenges, data and knowledge management was a particularly significant issue. Based on our findings, we offer design recommendations for empowering community-based social service organizations and the people they serve through technology. By leveraging the capabilities of technology, our study aims to promote social justice by assisting community-based organizations in better serving their communities.
Usefulness of QoS in Multidimensional QoE Prediction for Haptic–Audiovisual Communications
Authors: Tasaka Shuji
Published: August 2023

This article investigates prediction of Quality of Experience (QoE) by comparing borrowing-from-neighbor situations and isolated ones. We demonstrate that joint utilization of multiple QoE measures enhances the accuracy of QoE prediction compared to that by a collection of individual QoE measures each regressed on Quality of Service (QoS) parameters, while the accuracy improvement with additional usage of QoS information in the former is limited. As an example of system that needs multidimensional QoE representation, the article gives haptic audiovisual interactive communications. We employ QoE and QoS data taken previously in an experiment, where 13 QoE measures (a five-point score each) and 12 QoS parameters (nonnegative continuous values each) are available at three average rates of load traffic. We build two kinds of Bayesian models for QoE prediction; one is a logistic regression model of a single QoE measure as the response variable and QoS parameters as predictors, which is a typical traditional method of discrete QoE prediction and isolated in a sense. The other is a structural equation model (SEM) with latent constructs (i.e., factors) of audiovisual quality, haptic quality, and user experience quality; the original SEM, which contains only QoE indicators of three constructs (audiovisual quality (AVQ), haptic quality (HQ), and user experience quality (UXQ)), was proposed in one of the author’s previous studies. This article extends the SEM to accommodate QoS parameters. We develop two kinds of new SEMs with QoS parameters: One has three extended constructs referred to as eAVQ, eHQ, and eUXQ, each of which has both QoE and QoS indicators, and the other has separate constructs for QoE and QoS, which lead to totally six constructs (AVqoe, Hqoe, UXqoe, AVqos, Hqos, and UXqos). We performed Markov chain Monte Carlo simulation of the Bayesian models with the JAGS software in an R environment. For comparison of QoE prediction accuracy, we adopt the 10-fold cross validation method and in part widely applicable information criterion. We then found that the three-construct models outperform the logistic regression models with respect to all subjective QoE measures and that the two kinds of the models are comparable as for the objective measure. The six-construct model exhibits almost the same accuracy as that of the three-construct one unless the number of QoE measures (

n
qoe

) in the model is small. When the number

n
qoe

is small, single-construct models may be a better choice. We have thus learned that multiple QoE measures should be utilized jointly (i.e., borrowing from neighbor) in QoE prediction rather than resorting to QoS information only.
In Vitro Coculture of Primary Human Cells to Analyze Angiogenesis, Osteogenesis, and the Inflammatory Response to Newly Developed Osteosynthesis Material for Pediatric Maxillofacial Traumatology: A Potential Pretesting Model before In Vivo Experiments
Authors: Dohle Eva , Fecht Tatjana , Wolfram Tobias , Reinauer Frank , Wunder Anke , Heppe Katja , Sader Robert , Kirkpatrick Charles James , Ghanaati Shahram
Published: August 2023

During the present study, an in vitro coculture bone tissue mimic based on primary osteoblasts and primary endothelial cells was used for a complex and broad evaluation of a newly developed material for applications in pediatric maxillofacial traumatology. The biomaterial was composed of PDLLA (poly(D,L-lactide)) in various combinations with calcium carbonate (CC), magnesium (Mg), and chitosan (CH). Besides classical biocompatibility analyses, the present study evaluated material-dependent effects on fundamental processes that are essential for successful material integration and regeneration. Therefore, inflammation-associated factors such as E-selectin and interleukins were analyzed in the in vitro model system on gene expression and protein level depending on the different materials. Furthermore, in order to test the capability of vascularization of the material, the effect of the different materials on the formation of microvessel-like structures as well as the expression and release of proangiogenic factors was investigated in vitro in the bone coculture model. In addition, the mineralization capacity as well as the relative gene expression of osteogenic differentiation factors was analyzed in response to the different materials. As a result, the authors could assess the material combination PDLLA: CC CH as the most functionally tested material with regard to biocompatibility, inflammatory response, and microvessel-like structure formation as well as osteogenic differentiation in the in vitro coculture system. In conclusion, by using tissue-engineered human bone tissue equivalents as proposed here in an in vitro coculture model, biomaterial-mediated effects can be readily investigated. Moreover, it is proposed that these complex in vitro evaluations could contribute to the understanding and improvement of the development of novel materials for pediatric traumatological care for prospective clinical applications.
Chemometric Classification of Mangifera indica L. Leaf Cultivars, Based on Selected Phytochemical Parameters; Implications for Standardization of the Pharmaceutical Raw Materials
Authors: Kaggwa Bruhan , Nakayita Maria Gloria , Munanura Edson Ireeta , Kyeyune Henry , Ajayi Clement Olusoji , Wangalwa Raphael , Walakira Daniel Pillah , Anywar Godwin , Bagoloire Lynn K. , Kakazi Teddy , Ddamulira Gabriel , Kamba Fadhiru Pakoyo , Ogwang Patrick Engeu
Published: August 2023

Introduction. Mangifera indica leaves are among the most common materials employed in manufacturing herbal medicinal products. Despite the phytochemical variation of M. indica cultivars, there are no monographs to guide the cultivation, processing, and authentication of the materials. Methods. This study characterized 15 Ugandan M. indica leaf varieties, with reference to extraction index (EI), total phenolic content (TPC), antioxidant activity (AOA), and mangiferin concentration (MC). In addition, HPLC fingerprints were established to evaluate the overall phytoequivalence of the materials. Then, using hierarchical clustering (HC) and principal component analysis (PCA), the materials were assigned quality grades. Results. The mean EI was 9.39 ± 1.64% and varied among the varieties (P = 0.001); the TPC varied significantly (P < 0.0001), from 183.29 ± 2.36 mg/g (Takataka) to 79.47 ± 0.58 mg/g (Apple mango). AOA ranged from 16.81 ± 2.85 μg/mL (Doodo red) to 87.85 μg/mL (Asante). MC varied significantly (P < 0.0001), from 105.75 ± 0.60 mg/g (Kate) to 39.53 ± 0.30 mg/g (Asante). HC gave four major grades: A to D (A, varieties with the highest TPC, MC, and AOA). These parameters reduced to below average from group B to group D. The chromatographic fingerprints were visually similar, but the number of peaks varied, from 19 (Kawanda green) to 29 (Kawanda wide), with 23.5 ± 2.9 average peaks. Whole fingerprints were less similar (r < 0.8) than common peak fingerprints (r > 0.9, P < 0.001). PCA grouped the fingerprints into five clusters; loading plots for PC 1 and 2 revealed two important compounds, one at Rt = 15.828 minutes (mangiferin) and the other at 6.021 minutes. Using the standardized common fingerprints, unknown field samples clustered closely with Koona, Kate, and Kawanda green varieties. Conclusions. The EI, TPC, MC, and AOA values can be utilized to monitor consistency in the quality of materials and the production process. The grades generated can be used to select materials for cultivation and manufacturing. Where minimum concentrations are set, materials of different concentrations are used to dilute or concentrate each other. The HPLC fingerprints can be utilized to authenticate the materials. More samples from different agroecological regions of the country should be tested to cater to climatic variations in order to develop GMP‐compliant botanical identification methods.
Assessing the Alignment of Short‐Term Assessment of Risk and Treatability (START) with NANDA‐I Taxonomy in Forensic Care Settings
Authors: Grbovic Filip , Åling Maria , Strömberg Lars , Mazaheri Monir
Published: August 2023

Purpose. To investigate the alignment of START with NANDA‐I in forensic psychiatric care. Design. A quantitative design was chosen to compare the START instrument with the NANDA‐I taxonomy and analyze their alignment. Each item of the START was attempted to be matched with potentially relevant NANDA‐I diagnoses, and the matched diagnoses were extracted and presented. Findings. The study demonstrated a strong alignment between START coding and NANDA‐I diagnoses, with 99% of the START diagnoses finding a match within NANDA‐I. These results support the use of NANDA‐I in forensic psychiatric care, which facilitate providing comprehensive care and avoiding sole focus on psychiatric problems. Practice Implications. It is recommended to use a structured nursing taxonomy, such as NANDA‐I, in forensic psychiatric care.
Effect of Electrical and Chemical Autapse on the Firing Pattern and Synchronization of the Rulkov Neuron Model
Authors: Parthasarathy Sriram , Parastesh Fatemeh , Natiq Hayder , Rajagopal Karthikeyan , Jafari Sajad
Published: August 2023

The Rulkov map model is an efficient model for reproducing different dynamics of the neurons. In specific neurons, the electrical activity is regulated by time-delayed self-feedback called autapse. This paper investigates how the dynamics of the Rulkov model change by considering the autaptic current. Both electrical and chemical autapses are considered, and bifurcation diagrams are plotted for different autapse gains and time delays. Consequently, various firing patterns of the model are illustrated. The results represent that the firing pattern is greatly dependent on the values of autapse parameters. Moreover, the average firing frequency is computed and it is shown that the enhanced firing activity is induced by the inhibitory autapse. The synchronous dynamics of coupled Rulkov maps in the presence of autapse is also studied. It is shown that the electrical autapse enhances synchronization in small time delays, while the enhancement is achieved by chemical autapse in any time delay. However, increasing the time delay reduces the synchronization region.
Development of a Rare Earth Nanoprobe Enables In Vivo Real-Time Detection of Sentinel Lymph Node Metastasis of Breast Cancer Using NIR-IIb Imaging
Authors: Zhu Yuan-Yuan , Song Liang , Zhang Yong-Qu , Liu Wan-Ling , Chen Wei-Ling , Gao Wen-Liang , Zhang Li-Xin , Wang Jia-Zheng , Ming Zi-He , Zhang Yun , Zhang Guo-Jun
Published: August 2023

Sentinel lymph node (SLN) biopsy plays a critical role in axillary staging of breast cancer. However, traditional SLN mapping does not accurately discern the presence or absence of metastatic disease. Detection of SLN metastasis largely hinges on examination of frozen sections or paraffin-embedded tissues post-SLN biopsy. To improve detection of SLN metastasis, we developed a second near-infrared (NIR-II) in vivo fluorescence imaging system, pairing erbium-based rare-earth nanoparticles (ErNP) with bright down-conversion fluorescence at 1,556 nm. To visualize SLNs bearing breast cancer, ErNPs were modified by balixafortide (ErNPs@POL6326), a peptide antagonist of the chemokine receptor CXCR4. The ErNPs@POL6326 probes readily drained into SLNs when delivered subcutaneously, entering metastatic breast tumor cells specifically via CXCR4-mediated endocytosis. NIR fluorescence signals increased significantly in tumor-positive versus tumor-negative SLNs, enabling accurate determination of SLN breast cancer metastasis. In a syngeneic mouse mammary tumor model and a human breast cancer xenograft model, sensitivity for SLN metastasis detection was 92.86% and 93.33%, respectively, and specificity was 96.15% and 96.08%, respectively. Of note, the probes accurately detected both macrometastases and micrometastases in SLNs. These results overall underscore the potential of ErNPs@POL6326 for real-time visualization of SLNs and in vivo screening for SLN metastasis.

Significance:

NIR-IIb imaging of a rare-earth nanoprobe that is specifically taken up by breast cancer cells can accurately detect breast cancer macrometastases and micrometastases in sentinel lymph nodes.
Independent of Primary Sclerosing Cholangitis and Cirrhosis, Early Adulthood Obesity Is Associated with Cholangiocarcinoma
Authors: Hatia Rikita I. , Eluri Madhulika , Hawk Ernest T. , Shalaby Akram , Karatas Elif , Shalaby Ahmed , Abdelhakeem Ahmed , Abdel-Wahab Reham , Chang Ping , Rashid Asif , Jalal Prasun K. , Amos Christopher I. , Han Younghun , Armaghany Tannaz , Shroff Rachna T. , Li Donghui , Javle Milind , Hassan Manal M.
Published: August 2023

Background:

It is estimated that 6% to 20% of all cholangiocarcinoma (CCA) diagnoses are explained by primary sclerosing cholangitis (PSC), but the underlying risk factors in the absence of PSC are unclear. We examined associations of different risk factors with intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) in the United States.

Methods:

We conducted a case–control study of 121 patients with ECC and 308 patients with ICC treated at MD Anderson Cancer Center between May 2014 and March 2020, compared with 1,061 healthy controls. Multivariable logistic regression analysis was applied to estimate the adjusted OR (AOR) and 95% confidence interval (CI) for each risk factor.

Results:

Being Asian, diabetes mellitus, family history of cancer, and gallbladder stones were associated with higher odds of developing ICC and ECC. Each 1-unit increase in body mass index in early adulthood (ages 20–40 years) was associated with a decrease in age at diagnosis of CCA (6.7 months, P < 0.001; 6.1 months for ICC, P = 0.001; 8.2 months for ECC, P = 0.007). A family history of cancer was significantly associated with the risk of ICC and ECC development; the AORs (95% CI) were 1.11 (1.06–1.48) and 1.32 (1.01–2.00) for ICC and ECC, respectively.

Conclusions:

In this study, early adulthood onset of obesity was significantly associated with CCA and may predict early diagnosis at younger age than normal weight individuals.

Impact:

The study highlights the association between obesity and CCA, independent of PSC. There is a need to consider the mechanistic pathways of obesity in the absence of fatty liver and cirrhosis.
The Association of Kidney Function and Inflammatory Biomarkers with Epithelial Ovarian Cancer Risk
Authors: Hathaway Cassandra A. , Townsend Mary K. , Sklar Elliot M. , Thomas-Purcell Kamilah B. , Terry Kathryn L. , Trabert Britton , Tworoger Shelley S.
Published: August 2023

Background:

One of the mechanisms of ovarian tumorigenesis is through inflammation. Kidney dysfunction is associated with increased inflammation; thus, we assessed its relationship with ovarian cancer risk.

Methods:

In prospectively collected samples, we evaluated the association of kidney function markers and C-reactive protein (CRP) with ovarian cancer risk in the UK Biobank. We used multivariable-adjusted Cox proportional hazards models to evaluate quartiles of serum and urine markers with ovarian cancer risk overall and by histology. We assessed effect modification by CRP (≤3.0, >3.0 mg/L).

Results:

Among 232,908 women (1,110 ovarian cancer cases diagnosed from 2006–2020), we observed no association between estimated glomerular filtration rate and ovarian cancer risk (Q4 vs. Q1: HR, 1.00; 95% confidence intervals, 0.83–1.22). Potassium was associated with endometrioid (Q4 vs. Q1: 0.33, 0.11–0.98) and clear cell (4.74, 1.39–16.16) tumors. Poor kidney function was associated with a nonsignificant increase in ovarian cancer risk among women with CRP>3.0 mg/L (e.g., uric acid Q4 vs. Q1; 1.23, 0.81–1.86), but not CRP≤3.0 mg/L (0.83, 0.66–1.05). Other associations did not vary across CRP categories.

Conclusions:

Kidney function was not clearly associated with ovarian cancer risk. Larger studies are needed to evaluate possible histology specific associations. Given the suggestive trend for increased ovarian cancer risk in women with poor kidney function and high CRP, future work is needed, particularly in populations with a high prevalence of inflammatory conditions.

Impact:

This study provided the first evaluation of markers of kidney function in relation to ovarian cancer risk.
FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for Ubiquitination
Authors: Dong Bo , Song Xiang , Wang Xinzhao , Dai Tao , Wang Jianlin , Yu Zhiyong , Deng Jiong , Evers B. Mark , Wu Yadi
Published: August 2023

Lysine-specific demethylase 1 (LSD1), a critical chromatin modulator, functions as an oncogene by demethylation of H3K4me1/2. The stability of LSD1 is governed by a complex and intricate process involving ubiquitination and deubiquitination. Several deubiquitinases preserve LSD1 protein levels. However, the precise mechanism underlying the degradation of LSD1, which could mitigate its oncogenic function, remains unknown. To gain a better understanding of LSD1 degradation, we conducted an unbiased siRNA screening targeting all the human SCF family E3 ligases. Our screening identified FBXO24 as a genuine E3 ligase that ubiquitinates and degrades LSD1. As a result, FBXO24 inhibits LSD1-induced tumorigenesis and functions as a tumor suppressor in breast cancer cells. Moreover, FBXO24 exhibits an inverse correlation with LSD1 and is associated with a favorable prognosis in breast cancer patient samples. Taken together, our study uncovers the significant role of FBXO24 in impeding breast tumor progression by targeting LSD1 for degradation.

Implications:

Our study provides comprehensive characterization of the significant role of FBXO24 in impeding breast tumor progression by targeting LSD1 for degradation.
Supplementary Figure S5 from Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with MDM2 Amplification: An Open-Label Phase Ib/II Study
Authors: Koyama Takafumi , Shimizu Toshio , Kojima Yuki , Sudo Kazuki , Okuma Hitomi Sumiyoshi , Shimoi Tatsunori , Ichikawa Hitoshi , Kohsaka Shinji , Sadachi Ryo , Hirakawa Akihiro , Yoshida Akihiko , Ando Reiko Makihara , Ueno Toshihide , Yanagaki Mitsuru , Matsui Naoko , Nakamura Kenichi , Yamamoto Noboru , Yonemori Kan
Published: August 2023

Correlation between the MDM2 copy number and tumor shrinkage
Figure S3 from SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy
Authors: Drilon Alexander , Sharma Manish R. , Johnson Melissa L. , Yap Timothy A. , Gadgeel Shirish , Nepert Dale , Feng Gang , Reddy Micaela B. , Harney Allison S. , Elsayed Mohamed , Cook Adam W. , Wong Christina E. , Hinklin Ronald J. , Jiang Yutong , Brown Eric N. , Neitzel Nickolas A. , Laird Ellen R. , Wu Wen-I , Singh Anurag , Wei Ping , Ching Keith A. , Gaudino John J. , Lee Patrice A. , Hartley Dylan P. , Rothenberg S. Michael
Published: August 2023

Supplementary Figure 3: Preclinical development of PF-07284892
Table S2 from Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential
Authors: Sans Marta , Makino Yuki , Min Jimin , Rajapakshe Kimal I. , Yip-Schneider Michele , Schmidt C. Max , Hurd Mark W. , Burks Jared K. , Gomez Javier A. , Thege Fredrik I. , Fahrmann Johannes F. , Wolff Robert A. , Kim Michael P. , Guerrero Paola A. , Maitra Anirban
Published: August 2023

Gene markers per each of the scMC clusters from the IPMN dataset
Table S19 from Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential
Authors: Sans Marta , Makino Yuki , Min Jimin , Rajapakshe Kimal I. , Yip-Schneider Michele , Schmidt C. Max , Hurd Mark W. , Burks Jared K. , Gomez Javier A. , Thege Fredrik I. , Fahrmann Johannes F. , Wolff Robert A. , Kim Michael P. , Guerrero Paola A. , Maitra Anirban
Published: August 2023

Differentially expressed genes between NKX6-2 overexpressing and control Kras;Gnas cell line.
Data from Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting
Authors: Stossel Chani , Raitses-Gurevich Maria , Atias Dikla , Beller Tamar , Glick Gorman Yulia , Halperin Sharon , Peer Eyal , Denroche Robert E. , Zhang Amy , Notta Faiyaz , Wilson Julie M. , O'Kane Grainne M. , Haimov Talmoud Elina , Amison Nora , Schvimer Michael , Salpeter Seth J. , Bar Vered , Zundelevich Adi , Tirosh Itay , Tal Rotem , Dinstag Gal , Kinar Yaron , Eliezer Yonatan , Ben-David Uri , Gavert Nancy S. , Straussman Ravid , Gallinger Steven J. , Berger Raanan , Golan Talia
Published: August 2023

Abstract
Germline BRCA–associated pancreatic ductal adenocarcinoma (glBRCA PDAC) tumors are susceptible to platinum and PARP inhibition. The clinical outcomes of 125 patients with glBRCA PDAC were stratified based on the spectrum of response to platinum/PARP inhibition: (i) refractory [overall survival (OS) <6 months], (ii) durable response followed by acquired resistance (OS <36 months), and (iii) long-term responders (OS >36 months). Patient-derived xenografts (PDX) were generated from 25 patients with glBRCA PDAC at different clinical time points. Response to platinum/PARP inhibition in vivo and ex vivo culture (EVOC) correlated with clinical response. We deciphered the mechanisms of resistance in glBRCA PDAC and identified homologous recombination (HR) proficiency and secondary mutations restoring partial functionality as the most dominant resistant mechanism. Yet, a subset of HR-deficient (HRD) patients demonstrated clinical resistance. Their tumors displayed basal-like molecular subtype and were more aneuploid. Tumor mutational burden was high in HRD PDAC and significantly higher in tumors with secondary mutations. Anti–PD-1 attenuated tumor growth in a novel humanized glBRCA PDAC PDX model. This work demonstrates the utility of preclinical models, including EVOC, to predict the response of glBRCA PDAC to treatment, which has the potential to inform time-sensitive medical decisions.
Significance:
glBRCA PDAC has a favorable response to platinum/PARP inhibition. However, most patients develop resistance. Additional treatment options for this unique subpopulation are needed. We generated model systems in PDXs and an ex vivo system (EVOC) that faithfully recapitulate these specific clinical scenarios as a platform to investigate the mechanisms of resistance for further drug development.

This article is highlighted in the In This Issue feature, p. 1749
Long-Term Safety, Outcome, and Clinical Effects of Subcutaneous and Intravenous Treprostinil Treatment in Patients with Severe Chronic Pulmonary Arterial Hypertension
Authors: Harutyunova Satenik , Benjamin Nicola , Eichstaedt Christina , Marra Alberto M. , Xanthouli Panagiota , Nagel Christian , Grünig Ekkehard , Egenlauf Benjamin
Published: August 2023

Background: Current guidelines recommend treatment with parenteral prostacyclin analogs in patients with severe pulmonary arterial hypertension (PAH), who have insufficient response to treatment. Real-life data are sought to help physicians in treatment decisions and clinical care of patients. Objective: This study analyzed safety, clinical effects, and long-term outcomes of subcutaneous (sc) and/or intravenous (iv) treprostinil via different pump systems in consecutive patients with PAH. Methods: Thirty-seven patients with severe progressive PAH despite dual combination therapy (20 female, mean age: 52.3 ± 15 years, mean pulmonary vascular resistance: 12.1 ± 5.1 WU) were initiated with add-on treprostinil sc and were routinely clinically assessed. Changes in clinical parameters, adverse events, and outcome were analyzed retrospectively. Results: In 24 of 37 patients, treprostinil administration was continued iv via implantation of LENUS Pro® pump after 3 ± 1.3 months, 6 patients continued with sc therapy, and 7 discontinued treatment. After 3, 6, 9, and 12 months of treprostinil treatment, patients showed a significant improvement in mean 6-min walk distance and tricuspid annular plane systolic excursion compared to baseline. In 8 of the 24 patients, iv pumps required surgical revision. During a mean follow-up of 2.82 ± 1.95 years, 12 patients died, four received lung transplantation. Transplant-free survival after 1, 2, and 3 years was 85.7%, 69.2%, and 65.3%, respectively. Conclusion: sc treprostinil as add-on to double combination treatment significantly improved exercise capacity and right heart function. In most patients, treprostinil could be continued via more tolerable iv administration approach (LENUS Pro® pump), showing reasonable overall survival with respect to the severity of PAH.
Redes políticas no circuito espacial de produção da madeira no Paraná
Authors: Santos Patricia , Silva Márcia da
Published: August 2023

O processo de globalização cria novas formas e novos conteúdos aos espaços, especialmente aos elementos relacionados às mudanças tecnológicas (fluxos de informações) na reprodução do capital. Diante dessas novas formas e conteúdos elencamos a dinâmica da teoria dos circuitos espaciais de produção. A partir desses elementos buscamos como objetivo compreender o circuito espacial de produção da madeira, tendo como enfoque a relação dos elementos político-econômicos deste processo,expostos pela dinâmica das redes políticas, na configuração territorial no Paraná. Para isso, utilizamos da base teórico-metodológica das redes para identificar os círculos de cooperação e apontar os elementos determinantes para definir o poder de decisão e localização dos atores. Consideramos desta forma, a partir de uma metodologia específica das redes políticas, onde procuramos analisar e traçar, o perfil dos atores presentes no circuito espacial de produção da madeira e suas respectivas relações, que neste caso são compreendidas do ponto de vista político e econômico. Utilizamo-nos, desta forma, dos elementos dispostos a partir da aplicação de questionário com dez atores pesquisados e, toda uma rede de dados sobre o setor. Consideramos, portanto, que elementos como a circularidade, presente na dinâmica dos circuitos e evidenciada pelas relações político-econômicas dos círculos de cooperação, expõe-se na configuração de uma rede política dotada de poder.
Cães naturalmente infectados por Rangelia vitalii, Babesia canis vogeli, e Ehrlichia canis em São Paulo, Brasil
Authors: Batista Thais Fernandes , Cortez Adriana , Labruna Marcelo Bahia , Nascimento Daniel Pedro Barbosa , Lopes Ricardo Duarte , Moraes Filho Jonas
Published: August 2023

As hemoparasitoses em cães podem ser causadas por diversos agentes, sendo essas doenças transmitidas por artrópodes hematófagos. Esses agentes podem causar diversas manifestações clínicas e, em alguns casos, podem matar o hospedeiro. Este estudo teve como objetivo detectar por PCR em tempo real a frequência de Ehrlichia canis, Rickettsia rickettsii, Anaplasma platys, Rangelia vitalii e Babesia canis vogeli em amostras de cães da zona sul da cidade de São Paulo, Brasil. Das 98 amostras de cães, 18 (18,4%) testaram positivo com reação em cadeia da polimerase em tempo real para pelo menos um agente estudado. Destas 18 amostras, 17 testaram positivo para um único agente (11,2% para B. canis vogeli, 1,02% para R. vitalii e 5,1% para E. canis), e uma apresentou coinfecção com B. canis vogeli e R. vitalii. Os resultados demonstram a presença de hemoparasitas nos animais estudados, o que pode influenciar a qualidade e a expectativa de vida desses animais. Além disso, é o primeiro relato da detecção de R. vitalli na zona sul de São Paulo e serve de alerta para os clínicos de pequenos animais incluírem esse agente como diagnóstico diferencial para as hemoparasitoses.
Processos criativos nos projetos finais de graduação do curso de artes visuais da Universidade Estadual de Campinas
Authors: Pfutzenreuter Edson
Published: August 2023

Este artigo estuda os processos criativos envolvidos no desenvolvimento do projeto experimental, que encerra o curso de Graduação em Artes Visuais da Unicamp. O objetivo é compreender os processos visando colaborar para projetos futuros, os quais serão desenvolvidos por outro(a)s estudantes. São apresentados dois trabalhos artísticos com preocupações sociais. Um trabalho explora o feminismo e outro a questão que envolve o cabelo da mulher negra.
Arquivo e processo de criação no estudo da produção jornalística de Ildásio Tavares: algumas considerações
Authors: Santos Rosa Borges dos , Mota Mabel Meira
Published: August 2023

O reconhecimento de um indivíduo como intelectual múltiplo (HOISEL, 2012) implica considerar que os registros por ele produzidos são definidos pelo modo idiossincrático como este se inscreve em diferentes domínios de produção de discursos, cada qual com suas práticas sociais e documentais peculiares. Ildásio Tavares atuou como escritor e também como colunista em diferentes veículos de comunicação baianos, como os jornais A Tarde, Diário de Notícias e Tribuna da Bahia. No Fundo Ildásio Tavares, custodiado pelo Lugares de Memória, a existência de documentos jornalísticos impõe aos pesquisadores uma série de desafios teóricos, metodológicos e de ordem prática, pois além de evidenciar a atuação de Tavares enquanto redator, tais documentos apontam para uma escrita jornalística em processo, da qual avultam as inúmeras versões que culminaram no registro impresso e veiculado nos periódicos mencionados. No presente trabalho, temos como objetivo examinar as especificidades semânticas e genéticas desses documentos para identificar e nomear os documentos jornalísticos no arquivo pessoal de Ildásio Tavares, valendo-nos do aporte metodológico da Crítica Genética e da Arquivologia. Por fim, pretendemos demonstrar a contribuição da Crítica Genética para a Arquivologia, no sentido de instrumentalizar a identificação e organização dos documentos a partir da compreensão da dinâmica e das particularidades do processo de criação na produção jornalística do autor.
Da crítica genética a outros saberes (e retorno)
Authors: Zeytounlian William
Published: August 2023

Resenha do livro A escritura pela rasura: a crítica genética em busca de outros saberes, organizado por Philippe Willemart.
Corpo, Desenho e Fotografia: Roberto Alencar e a criação da revista Murro em Ponta de Faca, nº 12
Authors: Dias Wagner Miranda
Published: August 2023

O objetivo deste artigo é investigar os processos criativos de Roberto Alencar, com base nos estudos de seus documentos (cadernos, desenhos, vídeos, fotografias e escritos). Será aqui discutida, de modo mais aprofundado, a 12ª edição da revista “Murro em Ponta de Faca” (2016), importante publicação sobre dança no Brasil, criada pela Companhia Carne Agonizante, da qual Alencar fazia parte como intérprete. Ele foi responsável pela produção gráfica da revista, que se estruturou a partir de cinco espetáculos sobre a obra de Franz Kafka, encenados pela Companhia de 2002 a 2013. A elaboração dessa edição se dá nos embates entre corpo, desenhos, textos, fotografias, vídeos e ideias que definem as imagens escolhidas. Um processo que propõe questões relevantes sobre interações interdisciplinares no corpo no contemporâneo, que serão discutidas à luz das teorias de Cecília Salles sobre crítica de processos de criação, que tem como base a semiótica de C.S. Peirce e propõe diálogos com autores como Edgar Morin, Vincente Colapietro, Pierre Musso, Lucia Santaella, Helena Katz e Christine Greiner.
“Tiempo de crear”: invención, deriva y proyección del portuñol a partir de la obra Mar Paraguayo (1992) de Wilson Bueno
Authors: Recchia Paez Juan
Published: August 2023

En el presente trabajo partiremos del análisis del contexto de producción de la obra Mar Paraguayo (1992) y de las formulaciones paratextuales que acompañaron el proceso crítico-genético de invención/creación de la obra de Wilson Bueno en la revista O Nicolau (1987-1998). En una segunda instancia, a 10 años de la publicación de Mar Paraguayo, abordaremos el proceso de deriva de lecturas críticas literarias sobre las operaciones de “traducción” en obras producidas en portuñol en el continente sudamericano. Y, en tercer lugar, en dicho análisis nos detendremos sobre la proyección futura que habilita el uso del portuñol como posibilidad material en la concreción de un proyecto literario que, al día de hoy, desafía los límites de lo que comprendemos como literatura latinoamericana.
Association Between Prenatal Diagnosis and Age at Surgery for Noncritical and Critical Congenital Heart Defects
Authors: Woo Joyce L. , Laternser Christina , Anderson Brett R. , Grobman William A. , Monge Michael C. , Davis Matthew M.
Published: August 2023

BACKGROUND:

The relationship between the prenatal diagnosis of congenital heart defects (CHDs) and age at CHD surgery is poorly understood, despite the known relationships between age at surgery and long-term outcomes. The objective of this study was to determine the associations between prenatal diagnosis of CHD and age at surgery, and whether these associations differ for critical and noncritical CHDs.

METHODS:

This is a cohort analysis of patients aged 0 to 9 years who received their initial cardiac surgery at Ann & Robert H. Lurie Children’s Hospital of Chicago between 2015 and 2021 with prenatal diagnosis as the exposure variable. All data were obtained from the locally maintained Society of Thoracic Surgeons Congenital Heart Surgery Database at Lurie Children’s Hospital. We used multivariable fixed effects regression models to estimate the strength of the association of prenatal diagnosis with age at surgery among patients with critical (surgery ≤60 days) and noncritical (surgery >60 days) CHDs.

RESULTS:

Of 1131 individuals who met inclusion criteria, 532 (47%) had a prenatal diagnosis, 428 (38%) had critical CHDs, 533 (47%) were female, and the median age at surgery was 119 days (interquartile range, 11–309 days). After controlling for demographics, comorbidities, and surgical complexity, the mean age at surgery was significantly younger in those with prenatally versus postnatally diagnosed critical CHD (7.1 days sooner,
P
<0.001) and noncritical CHDs (atrial septal defects [12.4 months sooner,
P
=0.037], ventricular septal defects [6.0 months sooner,
P
<0.003], and noncritical coarctation of the aorta [1.8 months sooner,
P
=0.010]).

CONCLUSIONS:

Younger age at CHD surgery, which is associated with postsurgical neurodevelopmental and physical outcomes, is significantly associated with prenatal CHD diagnosis. This relationship was identified for both critical and noncritical CHDs.
Weather-Driven Complementarity between Daily Energy Demand at One Location and Renewable Supply at Another
Authors: Fabry Frédéric , Samuel Joseph , Meunier Véronique
Published: August 2023

In a future world where most of the energy must come from intermittent renewable energy sources such as wind or solar energy, it would be more efficient if, for each demand area, we could determine the locations for which the output of an energy source would naturally match the demand fluctuations from that area. In parallel, meteorological weather systems such as midlatitude cyclones are often organized in a way that naturally shapes where areas of greater energy need (e.g., regions with more cold air) are with respect to windier or sunnier areas, and these are generally not collocated. As a result, the best places to generate renewable energy may not be near consumption sites; these may be determined, however, by common meteorological patterns. Using data from a reanalysis of six decades of past weather, we determined the complementarity between different sources of energy as well as the relationships between renewable supply and demand at daily averaged time scales for several North American cities. In general, demand and solar power tend to be slightly positively correlated at nearby locations away from the Rocky Mountains; however, wind power often must be obtained from greater distances and at altitude for energy production to be better timed with consumption.

Significance Statement

Weather patterns such as high and low pressure systems shape where and when energy is needed for warming or cooling; they also shape how much renewable energy from winds and the sun can be produced. Hence, they determine the regions where more energy is likely to be available in periods of unusually high need for each demand location. Finding where those areas are may result in more timely renewable energy production in the future to help reduce fossil fuel use for energy production.
Least-Squares Triple Cross-Wavelet and Multivariate Regression Analyses of Climate and River Flow in the Athabasca River Basin
Authors: Ghaderpour Ebrahim , Zaghloul Mohamed Sherif , Dastour Hatef , Gupta Anil , Achari Gopal , Hassan Quazi K.
Published: August 2023

River flow monitoring is a critical task for land management, agriculture, fishery, industry, and other concerns. Herein, a robust least squares triple cross-wavelet analysis is proposed to investigate possible relationships between river flow, temperature, and precipitation in the time–frequency domain. The Athabasca River basin (ARB) in Canada is selected as a case study to investigate such relationships. The historical climate and river flow datasets since 1950 for three homogeneous subregions of the ARB were analyzed using a traditional multivariate regression model and the proposed wavelet analysis. The highest Pearson correlation (0.87) was estimated between all the monthly averaged river flow, temperature, and accumulated precipitation for the subregion between Hinton and Athabasca. The highest and lowest correlations between climate and river flow were found to be during the open warm season and cold season, respectively. Particularly, the highest correlations between temperature, precipitation, and river flow were in May (0.78) for Hinton, July (0.54) for Athabasca, and September (0.44) for Fort McMurray. The new wavelet analysis revealed significant coherency between annual cycles of climate and river flow for the three subregions, with the highest of 33.7% for Fort McMurray and the lowest of 4.7% for Hinton with more coherency since 1991. The phase delay analysis showed that annual and semiannual cycles of precipitation generally led the ones in river flow by a few weeks mainly for the upper and middle ARB since 1991. The climate and river flow anomalies were also demonstrated using the baseline period 1961–90, showing a significant increase in temperature and decrease in precipitation since 1991 for all the three subregions. Unlike the multivariate regression, the proposed wavelet method can analyze any hydrometeorological time series in the time–frequency domain without any need for resampling, interpolation, or gap filling.
Measuring Willingness to Pay: A Comparative Method of Valuation
Authors: He Sharlene , Anderson Eric T. , Rucker Derek D.
Published: August 2023

Willingness to pay (WTP) is a metric that is widely valued and utilized among both practitioners and academics. However, the conceptualization of WTP is ambiguous, and this ambiguity is reflected across existing methods of measuring WTP. The authors first present a formal mathematical framework that clarifies WTP as a distributional concept—rather than a single number—constructed as a function of customers, comparisons, and situations. The framework further reveals the operation of two comparative mechanisms, direct and indirect, by which situational factors affect WTP. They then introduce a new method to measure WTP—the comparative method of valuation (CMV)—that, unlike existing methods, is designed to account for the inherently comparative and situational nature of WTP. Across nine studies reported in the article and four additional studies in the Web Appendix, the authors (1) examine differences in results between CMV and choice-based conjoint as well as between CMV and the classic Becker–DeGroot–Marschak methodology, (2) demonstrate that CMV is a valid and reliable measure of WTP, and (3) illustrate applications of CMV to managerial problems. This article offers both conceptual clarity and methodological advances to understanding the construction and measurement of WTP for practitioners and academics alike.