bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of intra-cultivar variability in Olea europaea L. cv. Leccino using morphological, biochemical and molecular markers
Authors: Petruccelli Raffaella , Beghè Deborah , Ganino Tommaso , Bartolini Giorgio , Ciaccheri Leonardo , Bernardi Rodolfo , Durante Mauro
Published: June 2020

The phenotypic and genotypic variability of olive tree cv. Leccino (Olea europaea L.), an ancient cultivar from North-Central Italy, was investigated using 44 quantitative and qualitative agro-morphological traits, SDS-PAGE of seed proteins (storage proteins and tegument proteins) and molecular markers such as RAPDs (30 primers) and SSRs (8 primers). Fifteen accessions of Olea europaea catalogued as "Leccino" and one certified tree of "Leccino" (LESt) were examined. The plants were clonally propagated and the measuring of all morphological characteristics was conducted over a period of seven years. The ANOVA analysis showed that all accessions were homogenous for many traits while very few variations were recorded for length of one year old shoots, leaf width, leaf length/leaf width ratio, fruit length, fruit fresh weight, fruit length/fruit width ratio, pit length and pit fresh weight. The PCA analysis and similarity coefficients confirmed a low level of variability of Leccino cultivar. SDS-PAGE analysis of seed proteins showed monomorphic patterns of storage proteins. Protein subunits of teguments revealed a generally high level of similarity as evidenced by Nei-Li coefficient. SSRs and RAPDs markers showed molecular monomorphism among Leccino accessions. The results of agro-morphological, biochemical and molecular nature, taken as a whole, seem to indicate a weakly differentiated/homogeneity of the accessions tested belonging to the Leccino cultivar. The limited morphological and genetic variation could support the assumptions of a monophyletic origin of Leccino cultivar with a genetically restricted base.
Assessment of genetic diversity in Thai upland rice varieties using SSR markers
Authors: Nilthong Somrudee , Chukeatirote Ekachai , Nilthong Rungrote
Published: June 2020

Upland rice (Oryza sativa L.) is precious genetic resource containing some valuable alleles not common in modern germplasm. In this study, genetic diversity and population structure of 98 upland rice varieties from northern part of Thailand were examined using nine simple sequence repeat markers. Number of alleles detected by the above primers was 50 with a minimum and maximum frequency of 2 to 10 alleles per locus, respectively. The polymorphic information content (PIC) values ranged from 0.375 to 0.714 with an average of 0.605 for the primers RM164 and RM1, respectively. Dendrogram cluster analysis of the SSR data distinctly classified all genotypes into three major groups (I, II and III), which corresponded to their places of collection. Population structure divided these genotypes into two distinct subpopulations. Subpopulation 1 consisted of upland rice varieties that collected from Chiang Rai province while the majority of subpopulation 2 were collected from Phayao and Phitsanulok provinces. Analysis of molecular variance revealed 68% variance among two subpopulations and 32% variance within subpopulations, suggesting a high genetic differentiation between the two subpopulations. The huge genetic variability of upland rice in northern part of Thailand can be used to complement the gene pool of modern genotypes in rice breeding program.
Nutraceutical coating composition for postharvest conservation of 'Paluma' guava
Authors: Alves Kalinny de Araújo , Araújo Railene Hérica Carlos Rocha de , Oliveira Agda Malany Forte de , Morais Fabricio Alves de , Onias Elny Alves , Teodosio Albert Einstein Mathias de Medeiros , Ferreira Ana Paula Nunes , Lima José Franciraldo de , Dias George Alves
Published: June 2020

This work assesses the influence of edible coating with nutraceutical properties on post-harvest conservation of guavas 'Paluma'. The experiment comprised of a completely randomized design with four replicates and three fruits per plot. Six treatments were applied combining different concentrations of agar and pomegranate seed oil (PS): T1: 1% agar and 0.1 mL/L PS oil; T2: 2% agar and 0.2 mL L-1 PS oil; T3: 3% agar and 0.3 mL L-1 PS oil; T4: 4% agar and 0.4 mL L-1 oil; T5: 5% agar and 0.5 mL L-1 oil; and T6: control (fruits without coating). After the immersion in treatment solutions, the guavas remained stored in an air-conditioned room for ten days at 10 °C and 40% RH. Fruits without coating (control) ripened faster than coated ones, so the treatments preserved fruit coloration. The treatments T4 and T5 provided the best preservation of peel color, suggesting slower ripening and maintenance of fruit quality, as their colors tended to green and opaque. The firmness of fruits without coating was decreased by 35.15% concerning the coated ones. Treatments T4 and T5 had the lowest loss of fresh mass. On the other hand, T5 showed the lowest soluble solids contents (SS)(13.46%). Titratable acidity (TA), SS/TA ratio, total sugars, and carotenoids were not affected by treatments. The edible coating with 4% of agar plus 0.4 mL L-1 of pomegranate seed oil promoted the best quality traits for the post-harvest preservation of the guavas 'Paluma'.
Agronomic performance of soybean genotypes in Brazil sub-subtropical climate
Authors: Demari Gustavo Henrique , Szareski Vinícius Jardel , Carvalho Ivan Ricardo , Bubans Valéria Escaio , Silva José Antonio Gonzalez da , Martins Andrea Bicca Noguez , Morizzo Leomir , Cavalcante Jerffeson Araujo , Matter Ester Mafalda , Magano Devid Araujo , Dubal Ítala Thaisa Padilha , Pimentel João Roberto , Escalera Ruddy Alvaro Veliz , Pedroso Carlos Eduardo , Souza Velci Queiróz de , Aumonde Tiago Zanatta , Pedó Tiago
Published: June 2020

Soybean is the main economic crop of Brazilian agribusiness, and the extreme south of the country is considered a new agricultural frontier. The objective of this study was to evaluate the components of the yield and agronomic performance of soybean genotypes in the south of Rio Grande do Sul as well as to verify the linear relationships of the measured characters. The study was carried out in the municipality of Pelotas, Rio Grande do Sul, Brazil, in the crop harvest 2016. The experimental design was a randomized complete block design, containing 25 soybean genotypes arranged in four replicates. The experimental units were composed of five sowing lines, spaced by 0.45 meters and three meters in length. The measured characters were: first pod insertion height, plant height, number of branches, length of branches, number of pods in the main stem, number of pods in the branches, number of pods with one, two, three and four seeds, contributing to the pod mass with one, two, three and four seeds. The data were submitted to analysis of variance at 5% of probability, where for the significant characters the averages were compared by the Duncan’s test and Pearson's linear correlation was performed in order to identify the tendency of association among the measured characters. The genotypes DM 6159IPRO, BS2606 IPRO, BMX Magna, BMX Potência, TMG7062 IPRO, LG 60163 IPRO revealed superior characters, which can positively influence grain yield. There is a correlation among the morphological characters of the soybean cultivated in southern Brazil between the number of pods in the main stem and the number of pods in the branches, as well as between the number of pods with two seeds and the number of pods in the branches.
Transcriptome analysis of oil palm (Elaeis guineensis Jacq.) roots under waterlogging stress
Authors: Nuanlaong Sunya , Wuthisuthimethavee Suwit , Mekanawakul Maruay , Suraninpong Potjamarn
Published: June 2020

Waterlogging seriously constrains growth and yields in oil palm. To date, the responsive molecular changes caused by waterlogging in oil palm remain elusive. To elucidate the molecular genetic mechanisms of waterlogging stress, two varieties of oil palm Deli x Lamé and Deli x Ghana were used. The transcriptome profiles of the roots under waterlogging stress and normal conditions were compared via Ion Torrent Sequencing. Four libraries (GNR, GSR, SNR, and SSR) of oil palm roots after 45 days of normal watering and waterlogging stress were constructed. Approximately 6.2 million sequenced reads per library were obtained, with 5.5 million mapped reads (88.64%) similar to the oil palm genome in the GenBank database. A comparison of GNR/GSR showed a high of 3,289 DEGs with most genes up-regulated (1,863 DEGs). The GO analysis revealed the distribution of the DEGs among various pathways, suggesting a wide spectrum of physiological processes impacted by waterlogging stress. Moreover, qRT-PCR showed strong expression of all selected RNA-seq genes in waterlogged Deli x Ghana (GSR), especially GST, SAPK10 and NAC29 that are reported for the time to respond to waterlogging stress. Thus, this study not only reveals the comprehensive mechanisms of waterlogging responsive transcription in oil palm, but also establishes Deli x Ghana as a highly-adaptable variety to waterlogging conditions.
The Morphosyntactic Behavior of the Preposition la in Sorani Kurdish Structures
Authors: RADNİA Zanko
Published: June 2020

This article aims to investigate the role of the preposition la in the structure of Sorani Kurdish verbs. As certain verbs are usually accompanied by la in different sentences, this paper explains in detail how this preposition is situated in the structure of those verbs by providing a syntactic as well as morphological treatment of their linguistic behavior. Verbs are classified into four main categories for the sake of studying them in detail. Deriving from a number of different sources, it is deemed necessary to make a distinction between two main classes of prepositions discussed in Kurdish grammar: simple and absolute, a distinction that also applies to la. Drawing upon this distinction, this article sets out the main framework of this discussion and explains thoroughly how this preposition can behave differently based on the host it is attached to or followed by in the sentence. The verbs will also be analyzed with respect to how many morphemes they are composed of and a morphemic analysis will be taken into account throughout. The preposition la also serves to provide an archaic type of ezafe (construct).
Water diversion and allocation for typical confined polder river-net in Taihu Basin
Authors: Xiang Long , Ma Mengting , Jiao Lihong , Liao Zhengmin
Published: June 2020

Hydraulic restoration in a confined polder river-net is a new issue under the concept of the Interconnected River System Network (IRSN) proposed by the Ministry of Water Resources (MWR) in China. This paper studies the typical hydrographic connection in the polder, and analyses the current situation of the hydrographic river-net in the typical area of Subaiwei in Changshu City by setting up a one-dimensional unsteady hydrodynamic model. The best water diversion-allocation schemes in the confined polder river-net are simulated and optimized in various scheduling rules. In order to recover the ability of hydro-connection and stream function, the effects of different scheduling rules and the duration time of water diversion under the ability of pump stations around polder boundary are compared. The results show that the optimized injects can enhance the total flow velocity and the exchange rate is more than 20% on average in various streams. This study is critical for the sustainable utilization of limited clean water in a confined river-net polder, and for quantifying the water ecological recharge for hydrodynamic connection.
Expression and Purification of the VpDef Defensin in Escherichia coli using the Small Metal-Binding Proteins CusF3H+ and SmbP
Authors: Montfort-Gardeazabal Jorge M. , Claudio Pilar C. Morales-San , Casillas-Vega Nestor G. , Zarate Xristo
Published: June 2020

Background:

The heterologous production of antimicrobial peptides in bacterial models
can produce insoluble proteins due to the lack of proper folding. Fusion proteins have been used to
increase the expression and solubility of these types of proteins with varying degrees of success.

Objectives:

Here, we demonstrate the use of the small metal-binding proteins CusF3H+ (9.9kDa)
and SmbP (9.9kDa) as fusion partners for the soluble expression of the bioactive antimicrobial peptide
VpDef(6.9 kDa) in Escherichia coli.

Methods:

The recombinant VpDef (rVpDef) peptide was expressed as a translational fusion with
CusF3H+ and SmbP in Escherichia coli SHuffle under different small-scale culture conditions.
The best conditions were applied to 1-liter cultures, with subsequent purification of the recombinant
protein through IMAC chromatography. The recombinant protein was digested using enterokinase
to liberate the peptide from the fusion protein, and a second IMAC chromatography step removed
the fusion protein. The purified peptide was tested against two Gram-positive and two
Gram-negative bacteria.

Results:

The use either of CusF3H+ or of SmbP results in recombinant proteins that are found in
the soluble fraction of the bacterial lysate; these recombinant proteins are easily purified through
IMAC chromatography, and rVpDef is readily separated following enterokinase treatment. The purified
rVpDef peptide exhibits antimicrobial properties against both Gram-positive and Gram-negative.

Conclusion:

Use of the fusion proteins CusF3H+ and SmbP results in production of a soluble recombinant
protein containing the antimicrobial peptide rVpDef that is correctly folded and that retains
its antimicrobial properties once purified.
Ribosome Hibernation as a Stress Response of Bacteria
Authors: Wang Tianwen , Liang Chen , Zheng Mengyuan , Liu Lu , An Yafei , Xu Hongju , Xiao Sa , Nie Lei
Published: June 2020

Ribosome is primarily regarded as the committing organelle for the translation process.
Besides the expansion of its function from a translational machine for protein synthesis to a regulatory
platform for protein quality control, the activity regulation and recycling of ribosome have
been deepened significantly. Recent advances have confirmed a novel mechanism in the regulation
of ribosome activity when a cell encounters adverse conditions. Due to the binding of certain protein
factors onto a ribosome, the structural and functional change of the ribosome inside the cell
will take place, thereby leading to the formation of inactive ribosomes (70S monomer or 100S
dimer), or ribosome hibernation. By ribosome hibernation, the overall protein synthesis rate of a
cell could be slowed down. The resistance to adverse conditions or chemicals of the host cell will
be enhanced. In this paper, we discussed the phenomenon, molecular mechanism, and physiological
effect of ribosome hibernation when cells are under stresses. And then, we discussed the resuscitation
of a hibernating ribosome and the role of ribosome hibernation in the treatment of antimicrobial
infection.
Advances in Sickle Cell Disease Treatments
Authors: Pavan Aline Renata , dos Santos Jean Leandro
Published: June 2020

Sickle Cell Disease (SCD) is an inherited disorder of red blood cells that is caused
by a single mutation in the β -globin gene. The disease, which afflicts millions of patients
worldwide mainly in low income countries, is characterized by high morbidity, mortality and
low life expectancy. The new pharmacological and non-pharmacological strategies for SCD is
urgent in order to promote treatments able to reduce patient’s suffering and improve their
quality of life. Since the FDA approval of HU in 1998, there have been few advances in discovering
new drugs; however, in the last three years voxelotor, crizanlizumab, and glutamine
have been approved as new therapeutic alternatives. In addition, new promising compounds
have been described to treat the main SCD symptoms. Herein, focusing on drug discovery, we
discuss new strategies to treat SCD that have been carried out in the last ten years to discover
new, safe, and effective treatments. Moreover, non-pharmacological approaches, including
red blood cell exchange, gene therapy and hematopoietic stem cell transplantation will be presented.
Gold Nanoparticles; Potential Nanotheranostic Agent in Breast Cancer: A Comprehensive Review with Systematic Search Strategy
Authors: Khandker Shahad Saif , Shakil Md. Salman , Hossen Md. Sakib
Published: June 2020

Background:

Breast cancer is a heterogeneous disease typically prevalent among women and is the
second-largest cause of death worldwide. Early diagnosis is the key to minimize the cancer-induced complication,
however, the conventional diagnostic strategies have been sluggish, complex, and, to some extent, non-specific.
Therapeutic tools are not so convenient and side effects of current therapies offer the development of novel
theranostic tool to combat this deadly disease.

Objective:

This article aims to summarize the advances in the diagnosis and treatment of breast cancer with gold
nanoparticles (GNP or AuNP).

Methods:

A systematic search was conducted in the three popular electronic online databases including PubMed,
Google Scholar, and Web of Science, regarding GNP as breast cancer theranostics.

Results:

Published literature demonstrated that GNPs tuned with photosensitive moieties, nanomaterials, drugs,
peptides, nucleotide, peptides, antibodies, aptamer, and other biomolecules improve the conventional diagnostic and
therapeutic strategies of breast cancer management with minimum cytotoxic effect. GNP derived diagnosis system
assures reproducibility, reliability, and accuracy cost-effectively. Additionally, surface-modified GNP displayed
theranostic potential even in the metastatic stage of breast cancer.

Conclusion:

Divergent strategies have shown the theranostic potential of surface tuned GNPs against breast cancer
even in the metastatic stage with minimum cytotoxic effects both in vitro and in vivo.
The Therapeutic Applications of Exosomes in Different Types of Diseases: A Review
Authors: Hosseini Mohammadbagher , Roshangar Leila , Raeisi Sina , Ghahremanzadeh Kazem , Negargar Sohrab , Tarmahi Vahid , Hosseini Vahid , Raeisi Mohammadreza , Rahimi Elnaz , Ebadi Zakiyeh
Published: June 2020

Exosomes are nano-sized vesicles secreted by nearly all cells and have
received massive attention recently. In addition to their roles in pathophysiological
processes and diagnostic evaluations, recently, several studies have applied exosomes
to design novel therapeutic applications. Exosomes can be derived from a variety of
cells and tissues and based on the source, they can carry different native contents such
as DNAs, non-coding small RNAs, mRNAs, and proteins. They can also be engineered
by adding desirable agents including specific biomolecules or drugs. Both forms can be
therapeutically used for delivering their cargoes to the target cells and desirably alter
their functions. The present study aimed to provide a comprehensive review of the
various studies which applied exosomes as a therapeutic tool in the treatment of
different types of diseases including cancer, cardiovascular, neurologic, psychiatric,
liver, and kidney diseases.
Circular RNAs and Glioma: Small Molecule with Big Actions
Authors: Abi Abbas , Ghaedi Kamran , Khosravi Alireza , Hayat Seyed Mohammad Gheibi
Published: June 2020

Glioma is known as one of very important tumors that is associated with high
rate of mortality worldwide. The mean rate of survival of these patients has not changed
(approximately 14 months) even with improvements in comprehensive therapeutic
approaches, such as chemotherapy, radiation, and surgery. Therefore, it seems that
new therapeutic or developed platforms are needed. In this regard, more understanding
about genetic and epigenetic modifications in the glioma, could contribute to finding and
developing these platforms. Among epigenetic mechanisms, circular RNAs have crucial
roles in the glioma pathogenesis. Reported by several studies, some of the abilities of
circRNAs include the exhibition of tissue specificity in humans and regulation of genes.
Research has also confirmed the participation of circRNAs in different pathological or
biological procedures, including migration, invasion, and apoptosis of glioma. Herein, we
summarized circular RNAs involved in glioma.
Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies
Authors: Hadda Taibi B. , Deniz Fatma S.S. , Orhan Ilkay E. , Zgou Hsaine , Rauf Abdur , Mabkhot Yahia N. , Bennani Brahim , Emam Dalia R. , Kheder Nabila A. , Asayari Abdulrhman , Muhsinah Abdullatif B. , Maalik Aneela
Published: June 2020

Background:

One of the best methods to treat Alzheimer disease (AD) is through the effective
use of cholinesterase inhibitors as vital drugs due to the identification of acetylcholine deficit in the
AD patients.

Objective:

The present study aims the investigation of spiro heterocyclic compounds as potential AD
agents supported by their metal chelation capacity, POM analyses and DFT studies, respectively.

Methods:

The cholinesterase inhibition and metal chelation ability were performed on ELISA microtiter
assay. Whereas, the B3LYP method with 6-31+G(d,p) basis set was implemented to study HOMOLUMO
energy calculations. The pharmacokinetic properties of the synthesized molecules were studied
through Petra, Osiris and Molinspiration (POM).

Results:

The six spiro (1-6) skeletons were tested for their inhibitory potential and metal-chelation capacity.
Our findings revealed that the tested spiro skeletons exerted none or lower than 50% inhibition
against both cholinesterases, while compound 4 proved to be the most active molecule with
57.21±0.89% of inhibition toward BChE. The spiro molecule 3 exhibited the highest metal-chelation
capacity (9.12±5.26%). Molecular docking model for the most active molecule exhibited promising
bindings with AChE and BChE’s active site pertained to hydrophobic hydrogen bonds and positive ionizable
interactions. The POM analyses gave the information about the flexibility at the site of coordination
of spiro compounds (1-6).

Conclusion:

The screening of spirocompounds (1-6) against cholinesterases revealed that some of them
show considerable potential to inhibit AChE and BChE. Herein, we propose that the spiro molecules
after further derivatization could serve interesting AD inhibitor drugs.
Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study
Authors: Krithika Uma , Prabitha Prabhakaran , Mandal Subhankar P. , Yuvaraj Sivamani , Priya Durai , Wadhwani Ashish D. , Prashantha Kumar Bommenahally Ravanappa
Published: June 2020

Background:

A series of novel 5-substituted benzylidene rhodanine derivatives using four
different amines were designed based on our previously developed CoMSIA (Comparative molecular
similarity indices analysis) model for the anticancer activity.

Methods:

The designed rhodanines were synthesized via dithiocarbamate formation, cyclization and
Knoevenagel condensation. The structures of the synthesized compounds were confirmed and analyzed
by spectral studies.

Results:

The synthesized rhodanines were investigated for in vitro anticancer activities and the analogs
have displayed mild to significant cytotoxicity against MCF-7 breast cancer cells. The compounds with
benzyloxy substitution at the fifth position of rhodanine ring (Compounds 20, 33 and 38) system showed
significant cytotoxic activity against MCF-7 cells. CoMSIA, a three-dimensional quantitative structureactivity
relationship (3D-QSAR) technique was accomplished to elucidate structure-activity relationships.

Conclusions:

Based on the information derived from CoMSIA contour plots, some key features for increasing
the activity of compounds have been identified and used to design new anti-cancer agents. The
present developed CoMSIA model displayed good external predictability, r2pred of 0.841 and good statistical
robustness.
Antihyperglycemic and Antihyperlipidemic Effects of Lippia citriodora in Rats
Authors: El-Ouady Fadwa , Eddouks Mohamed
Published: June 2020

Aims:

The study was conducted to assess the antidiabetic and antihyperlipidemic effects of
Lippia citriodora.

Background:

Lippia citriodora Kunth (Verbenaceae) is a medicinal plant with many traditional uses.

Objective:

The goal of this study was to investigate the antidiabetic activity of aqueous extract of Lippia citriodora and its capacity to improve the lipid profile in diabetic rats.

Methods:

Normal and diabetic rats were treated orally for 15 days by the leaves aqueous extract of
Lippia citriodora (LCLAE) (100 mg/kg). The whole glucose utilization and liver architecture were also
evaluated. The in vitro antioxidant activity of LCLAE was also assessed.

Results:

LCLAE lowered blood glucose and lipid levels in all groups. Moreover, LCLAE ameliorated
the liver structure and exhibited antioxidant activity.

Conclusion:

In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects
of LCLAE in rats.
The urban ethics of an AI-powered planetary urbanization
Authors: Chan Jeffrey
Published: June 2020

By 2100, the world may be entirely urbanized with every person living in cities. This imminent reality of planetary urbanization is likely to entail drastic environmental, economic, and social changes, all of which in turn are likely to impact the nature of human relations and their interactions in cities. Urban ethics is, therefore, concerned with the question of what ought to be the proper relations between people flourishing in the city? This question is presently compounded by the rise of the ‘smarter smart cities’, where urban technologies are enabled by artificial intelligence (AI) that can sense, track, learn, predict, and attempt to control human behaviors. The rapid confluence of these three developments, namely, planetary urbanization, urban ethics, and the AI-powered smart city, reveals an under-explored scenario pregnant with new social promises yet laced with many moral hazards. In this article, the following scenario, which is bounded by the following three vectors, will be examined: (i) How does the urban shape the ethical, and in what ways? (ii) What is the AI-powered smart city, and how does it impact the present notion of planetary urbanization? (iii) How does the AI-powered smart city change ethical agencies and in which specific ways? Together, the answers to these questions begin to further prime discussions in urban bioethics in the milieu of AI-powered cities.
Мандельштам-бриллюэновское рассеяние света в растворах бычьего сывороточного альбумина при различных концентрациях в окрестности тепловой денатурации
Authors: Дмитриев А.В. , Федосеев А.И. , Лушников С.Г.
Published: June 2020

Results of Brillouin light scattering studies of phase transformations in bovine serum albumin (BSA) in the temperature range 300 – 380 K in the protein solution with concentration 50 and 5 mg/ml are presented. In the analysis of the results, the sequence of phase transformations in a concentrated BSA solution (100 mg/ml) was used as a reference. It was shown that sequence of BSA phase transformations modified with a decrease in concentration. For instance, in the vicinity of denaturation, the region with fibril-like aggregate disappears, and the properties of the gel-like high temperature phase change.
Термоэлектрические и термоэлектрокинетические явления в коллоидных системах, модельных биологическим жидкостям живых организмов
Authors: Сидоров А.В. , Грабов В.М. , Зайцев А.А. , Кузнецов Д.В.
Published: June 2020

The paper presents the results of experimental measurements of thermoelectromotive force, thermoelectrokinetic EMF and conductivity coefficient in aqueous solutions, model in their properties and composition of human blood: medical ringer solution, serum albumin, ringer solution containing serum albumin. The influence of organic colloidal particles present in aqueous solutions of inorganic electrolytes on the value of their coefficient of thermoelectromotive force is analyzed. As follows from the results of the experiments, the coefficient of thermoelectromotive force of the studied liquids, based on the ringer solution, has a sharp dependence on temperature and acquires a large value in the temperature range in which the living human body functions. The obtained result indicates that the studied phenomena can play an important role in triggering the mechanisms of thermoregulation of living organisms.
Проблемы при использовании травителя KOH-IPA для текстурирования кремниевых пластин
Authors: Чучвага Н.А. , Кислякова Н.М. , Токмолдин Н.С. , Ракыметов Б.А. , Серикканов А.С.
Published: June 2020

The wet chemical treatment of monocrystalline silicon wafers, said method comprising texturing, represents one of the fundamental steps of manufacturing techniques of high-efficiency solar cells. As part of this work, methods for texturing single-crystal silicon wafers for solar cells were studied.As a result of studies, the optimal parameters of texturing technology for the studied samples were determined. The main type of etchant for texturing processes, which is a solution of KOH with isopropanol, is also determined.
SCHeLTI Platform: an Intervention Support System Tailored for a Randomized Controlled Trial (Preprint)
Authors: Hao Yanhui , Wu Yanting , Chen Zhirou , Fan Jianxia , Chen Lei , Yu Yamei , Liu Han , Vaillancourt Caroline , Zhou Yulai , Wang Lulu , Wang Liping , Xu Jian , Li Hong , Li Hong , Abdelouahab Nadia , Marc Isabelle , Fraser William , Huang Hefeng
Published: June 2020

BACKGROUND

With the rapid development of eHealth technologies, the convenient exchange of health-related electronic data can promote interactive exchange of information between healthcare providers (HCPs) and patients, making the communication between doctors and patients more coordinated and transparent. The Sino-Canada Healthy Life Trajectories Initiative (SCHeLTI) study is an ongoing randomized controlled trial to evaluate the effectiveness of a multifaceted, community-family-mother-child intervention on childhood overweight and obesity (OWO). A management system to support the SCHeLTI interventions needs to be developed.

OBJECTIVE

Considering the need for a supporting system to facilitate the implementation of interventions and the exchange of information between HCPs and participants, the SCHeLTI platform was designed and developed with the aim to facilitate the context-specific interventions in the SCHeLTI study.

METHODS

We tailored the SCHeLTI platform to the specifics of the SCHeLTI study. Multiple professional background experts were involved in the process of building the application, including the participation of personnel with medical professional background, clinical trials coordination and computer science. In the pilot phase, we collected feedback from HCPs and participants in the use process to further optimize the product.

RESULTS

The SCHeLTI platform includes the interworking and interconnection between the participants' mobile phone and the HCP's computers. A mobile application and a Web based management system were designed. The participant's terminal (the SCHeLTI APP) was successfully implemented and fully integrated into the intervention programme. The computer terminal managed by the research team create an innovative support environment that guides the participants toward healthy lifestyle changes.

CONCLUSIONS

A technically advanced and web-based management terminal and mobile phone app corresponding to the SCHeLTI needs were developed and used in the SCHeLTI study.

CLINICALTRIAL

trial registration No. ChiCTR1800017773
 Presentación
Authors: Peschard Mariscal Jacqueline
Published: June 2020

La coordinadora del número 28 de la RMOP presentalos trabajos dictaminados para la revista y explica su importancia para el campo de la opinión pública en el tiempo actual de México, América Latina y el mundo.
Proyectos y obras para el uso de los terrenos desecados del antiguo lago de Texcoco, 1912-1998
Authors: Soto Coloballes Natalia Verónica
Published: June 2020

El presente trabajo examina las ideas acerca del posible uso de la tierra descubierta debido a la desecación del lago de Texcoco, producto del Desagüe del Valle de México. El texto explica la variedad de ideas propuestas por ingenieros y otros expertos, muchos de los cuales imaginaron un espacio de múltiples usos, con fines agrícolas, silvícolas, recreativos y ecológicos. La aportación de esta investigación consiste en mostrar cómo y por qué esos planes e ideas cambiaron a lo largo del siglo XX. Los resultados muestran que la transformación de su aspecto y naturaleza ha sido un anhelo constante, limitado por las especiales condiciones del subsuelo. Para la realización de esta investigación se consultó un gran número de fuentes escritas y se acudió al Archivo Histórico y Biblioteca Central del Agua y al Museo Archivo de la Fotografía.
Nora Pérez-Rayón, El beso de la discordia. La V visita de Juan Pablo II a México. Iglesia Católica y prensa de opinión. Clericalismo, anticlericalismo, secularización y laicidad en la transición
Authors: Aguirre Cristiani María Gabriela
Published: June 2020

Reseña sobre Nora Pérez-Rayón, El beso de la discordia. La V visita de Juan Pablo II a México. Iglesia católica y prensa de opinión. Clericalismo, anticlericalismo, secularización y laicidad en la transición, México, Universidad Autónoma Metropolitana-Azcapotzalco, 2018.
Experimental Study on Mold-Lay Filament instead of Wax in Investment Casting Process
Authors: Kusyairi Imam , Himawan Helmy Mukti , Choiron Moch. Agus , Irawan Yudy Surya , Safari Rachmat , Djuanda Dagus Resmana
Published: June 2020

Metal casting with investment casting method is metal casting which has the ability to produce accurate parts and has a controlled fineness. Current technological developments are very influential in the development of investment casting. One of them has been found mold-lay filament as a substitute for wax, which is now wax is one of the main components in investment casting process. Mold-lay filament is printed using a 3D Printer machine. In this study, the wax in the investment casting process was replaced by a mold-lay filament with the specifications 0.75kg / 0.55 lb of 1.75mm MOLDLAY filament, prints at temperatures of 170-180° C. The result show that mold-lay flutes are also able to come out well from slurry molds, but require more time than wax, this is because one of the plastic mold-lay compositions, which takes a long time for the moldlay fillment to come out of the mold. Further research suggestions are needed further testing in terms of roughness of the product with moldlay filament and compared with wax. This will also see if there are any remaining moldlay filaments from the mold.
Investigating Fluid Parameters in Nanofiber Biomaterial Fabrication using Electrospinning
Authors: Yusro Muhammad , Martien Ronnie
Published: June 2020

Fabricating nanofiber biomaterial using electrospinning is difficult due to its bioactive characteristics. Even though electrospinning is mentioned as the most well-established approach to produce nanofiber, it is undeniable that fluid factors involved in determining the product result. In this research, three influenced factors including viscosity, conductivity, and surface tension are investigated in the system of Biomaterial Composite that contains mixed Chitosan-Pectin material blended to the Polyvinyl Alcohol (PVA). Various concentrations were made up to create an assorted liquid profile to some extent influencing fluid characteristic which affecting fabrication result. This research also analyzed the interaction between group materials using Fourier Transform Infra-Red (FTIR). Moreover, bead and spray phenomena which are commonly occurred in the process of fabrication are also deliberated correlating with fluid parameters. This experiment revealed that the range of the ability of the composite solution that can be fabricated was from 90/10 to 60/40 with the average diameter size for each composition are 90/10 = 155,39 ± 43,68 nm, 80/20 = 99,03± 26.01 nm, 70/30 = 111,387 ± 50,06 nm, and 60/40 = 107,06 ± 47,36 nm. Regarding fluid characteristics, the discrepancy related to the effect of viscosity to nanofiber size has occurred due to the nonuniform shape and type that affected the average size of the nanofiber. Meanwhile, the conductivity parameter found as the main reason related to the limited ability of the electrospinning process. Furthermore, the surface tension parameters noted as a factor that influencing droplet and beads formation.
Comparative Study of Forward Wingtip Fence and Rearward Wingtip Fence on Wing Airfoil Eppler E562
Authors: Hariyadi Setyo , Sutardi Sutardi , Widodo Wawan Aries , Pitoyo Bambang Juni
Published: June 2020

The perfect wing is a dream that many airplanes has manufactured have been striving to achieve since the beginning of the airplane design. There are some aspect that most influence in aircraft design lift, drag, thrust, and weight. The combination of these aspects leads to a decrease in fuel consumption, which reduces pollution in our atmosphere and increase in economic revenue. One way to improve aircraft performance is to modify the tip of the wing geometry, which has become a common sight on today’s airplanes. With computational programs, the effects on drag due to wingtip devices can be previewed. This research was done numerically by using turbulence model k-ω SST. Reynolds number in this research was 2,34 x 10 4 with angle of attacks are 0o, 2o, 4o, 6o, 8o, 10o, 12o, 15o, 17o and 19o. The model specimen is wing airfoil Eppler 562 with winglets. Two types of wingtips are used: forward and rearward wingtip fence. From this study, it was found that wingtip fence reduced the strength of vorticity magnitude on the x axis compared to plain wings. The leakage of fluid flow effect at the leading edge corner of the wingtip, giving pressure gradient and slightly shifting towards the trailing edge. this occurs in the plain wing and rearward wingtip fence but does not occur in the forward wingtip fence..
Experimental Investigation on Combustion Characteristics of Refine Corn Oil with Areca Catechu Extract as Additive
Authors: Wardoyo Wardoyo , Widodo Agung S. , Wijayanti Widya , Wardana I. N. G.
Published: June 2020

The need for vegetable oils as alternative energy reserves increases with the depletion of fossil energy sources. Vegetable oil is the strongest candidate to replace the fossil energy. However, the use of vegetable oil directly as fuel is limited by high viscosity. Viscosity like this results in non-ideal atomization, challenging to evaporate, and cannot burn completely. Among the methods that have been studied by previous researchers and which have proven to be effective, cheaper, and can reduce the viscosity of vegetable oils better is the mixing method. In this study, corn oil was mixed with areca extract as an additive. Areca extract contains polyphenols which are polar types of epicatechin. Epicatechin has three aromatic rings and several hydroxyl groups. Delocalisation of electrons in aromatic rings can produce London forces on vegetable oil molecules, thereby increasing the reactivity of burning vegetable oil droplets. The burning characteristics of corn vegetable oil affected by areca extract have been studied experimentally at room temperature and atmospheric pressure. The results showed that the rate and temperature of combustion increased, as well as the presence of micro explosions. The London force that appears causes the bonds in the triglyceride molecules to weaken so that the combustion becomes reactive, the rate of heat transfer in the droplets gets better, facilitates the appearance of micro explosions and increases the combustion temperature. Vegetable oil from corn has been studied experimentally at atmospheric pressure and room temperature. The results show an increase in the rate of combustion, an increase in combustion temperature, and the presence of micro explosions. London force that appears causes the bonds in the triglyceride molecules to weaken so that combustion becomes more reactive, the rate of heat transfer in the droplet gets better, facilitates the appearance of micro explosions and raises the combustion temperature.
Formulation and Evaluation of Transdermal Topical Gel of Ibuprofen
Authors: Kashyap Ankita , Das Asha , Ahmed Abdul Baquee
Published: June 2020

The present research work is based on the formulation and evaluation of topical gel of Ibuprofen where Carbopol 940 is used as the polymer. Gels were prepared by dispersing the polymers  in a mixture of water and glycerol with methyl paraben as the preservative and the varying amount of ibuprofen, being kept under magnetic stirring until the homogeneous dispersion was formed. The dispersion was then neutralized and made viscous by the addition of triethanolamine. The Carbopol gels of Ibuprofen were found to be homogenous with good drug loading. The pH of all the gel formulations was found within the neutral pH range which is compatible with skin. And the viscosity of the formulations was found to be feasible for topical drug delivery. The drug content of the three formulations was found in the range of 87.56% to 90.45% which shows efficient drug loading. Results of In vitro drug release study showed that F5 formulation has better diffusion of drug through egg membrane and hence further permeation studies were carried out through rat epidermis. The compatibility study showed that the major peaks in FTIR spectra of the pure drug were found to be intact in their physical mixture. Hence there is no interaction between drug and Carbopol in their physical mixture. Carbopol can be effectively used as the polymer for topical gel preparation. And F5 formulation containing 0.5 % w/w Carbopol 940 may be effectively used as topical transdermal delivery for Ibuprofen.

Keywords: Ibuprofen, Transdermal Gel, Drug release, Compatibility study
Preparation and Evaluation of Sulfacetamide Sodium Ocusert for Controlled Drug Delivery
Authors: Nagpal Manisha A , Sharma Karan , Anand Nupur , Singh Disha , Dhawan Ravi , Usman Md. Rageeb Md. , Nagpal Navneet
Published: June 2020

The intent of this research was to formulate and evaluate controlled release ocusert of sulfacetamide sodium for the treatment of bacterial conjunctivitis. Ocusert is a sterile preparation having drug as dispersion or as solution in the polymeric base. Prepared Ocuserts were formulated using hydroxyl propyl methyl cellulose K-15 and Ethyl cellulose as polymers at various concentrations and combinations. Polymeric Films were prepared by mercury casting method using different ratios of polymers. Selected physiochemical properties such as thickness, weight, percentage moisture absorption, and in-vitro release and sterility studies of sulfacetamide sodium ocusert were studied and reported that prepared ocusert resolved the problems of poor bioavailability, frequent dosing and wastage of active ingredient.

Keywords: Hydroxypropyl methyl cellulose K-15, ocusert, sulfacetamide sodium
Antitoxic, Antifungal and Phytochemical Analysis of Medicinal Compounds of Guiera senegalensis Leaves
Authors: Anka Z.M. , Singh Vijender , Gimba S.N. , Singh Gunjan
Published: June 2020

Millions of people in the world depend on traditional medicinal plants for treatment of many diseases.  They have curative properties due to presence of various complex chemical substances of different composition, which are found as secondary plant metabolites in one or more parts of these plants. These plant metabolites according to their composition are grouped as flavonoids, tannins, alkaloids, saponins etc. Guiera senegalensis(Gs), which grows in abundance in semi-desert area of Western Africa such as Nigeria, has been used for treating specific diseases and wounds. The study is carried out to investigate the phytochemical analysis, toxicity, and the antifungal activity of Gs leaves extract.

Keywords: Guiera senegalensis, Antifungal activity, Brine shrimp, toxicity, phytochemical analysis;
Synthesis and characterization of some novel coumarin based various 2-aryl-pyrido [3,2-c] coumarins
Authors: Pandya Mahesh K. , Parekh Tapan H. , Chhasatia Mehulsinh R. , Vala Nileshkumar D.
Published: June 2020

A survey of the literature reveals that the number of coumarin derivatives having heterocyclic moieties either as substituent groups or fused with parent coumarin nucleus possesses a variety of functions and are widely used in drugs and dyes. Because of this wide utility, the synthesis of coumarin has remained a subject of active interest. Looking at the importance of these heterocoumarins and with a view to exploring new methods of their synthesis, the present work was undertaken and  this synthesis deals with  various 2-aryl-pyrido [3,2-c] coumarins. The compounds have been synthesized by reacting Mannich bases of various 4-hydroxy coumarins with pyridinium salts of various aroyl methyl bromides in the presence of ammonium acetate and acetic acid. All the compounds synthesized have been characterized by analytical and spectral data.

Keywords: Pyrido, Coumarins, Krohanke’s reaction.
Antioxidant Activity of Centaurium erythraea Extracts
Authors: Merghem Mounira , Dahamna Saliha
Published: June 2020

Phototherapy has known a great evolution all the world and some medicinal plants are importance remedies of some diseases. Centaurium erythraea is one of the medicinal plants widely used in this field. In this study, we have evaluated the total polyphenolic and the flavonoid contents of the methanolic (ME) and aqueous (AqE) extracts of the plant Centaurium erythraea as well as its antioxidant activity using the DPPH (2'2-diphenylpicrylhydrazyl), β-carotene /linoleic acid bleaching and reducing power assays. The total polyphenolic content of the methanolic extract was 35,45± 0,041 μg AGE/mg extract and flavonoids was 6,65 ± 0,060 μg QE/mg. The total polyphenolic content of the aqueous extract was 54,27 ± 0,023 μg AGE/mg extract and flavonoids was 3,275 ± 0,003 μg QE/mg. The results of the DPPH test showed a powerful antioxidant activity with a very similar IC50 for the methanolic (IC50=0.232 ± 0.002mg/ml) and aqueous (0.208 ± 0.002mg/ml) extracts. The inhibitory activity of the tow extracts in the β-carotene/linoleic acid assay was (86.781 ± 0.17%) for the methanolic extract and (77.816 ± 0.69%) for the aqueous extract. ME has the higher reducing power (IC50 = 0.35 ± 0.066 mg / ml) compared to the AqE (IC50 = 1.31 ± 0.047 mg / ml).

Keywords: Centaurium erythraea, antioxidant activity, polyphenols, DPPH scavenging, β-carotene, reducing power.