bluuebunny/crossref_metadata_2025 huggingface dataset:
Academic System Management Berbasis Website di Sekolah Dasar Negeri 012 Langgini (Analyst)
Authors: Hidayat Muhammad , Gusman Deddy , Azriadi Emon
Published: September 2024

School is an educational institution that organizes formal education levels, either in the form of public schools, which are managed by the government or the private sector. In carrying out teaching and learning activities, schools aim to educate students under the supervision of teachers. School data processing is still done manually, so there are still many discrepancies in data management. The purpose of this research is to facilitate the school in managing academic data using a website that can be accessed easily. The research method used is the prototype method. And the design of this system uses the Unified Modeling Language (UML). The programming language used is PHP Framework Laravel and MySQL database. So that in this study the academic management system to process data from SDN 012 Langgini becomes more efficient.
Sistem Informasi Dealer Sepeda Motor Bekas Di Kecamatan Bangkinang Kota ( Analysis)
Authors: Shabri Muhammad , Musridho Raja Joko , Adeswastoto Hanantatur
Published: September 2024

Motorcycles are the most dominant means of transportation today, especially for the people of Bangkinang, and some people even prefer to look for used motorbikes because the prices are more affordable. Before someone starts deciding to get the desired means of transportation, they usually start by making several considerations. To find a used motorbike with certain criteria is a job that is quite difficult and troublesome and takes a long time, in order to get a used motorbike that really meets expectations, someone is willing to search every shop, this of course requires quite a lot of time and money. Therefore, this thesis builds a Web- based Information System for Used Motorcycle Dealers in Bangkinang Kota District so that it can help people find information on selling used motorbikes according to their needs. In testing the system using the blackbox testing method, all the features in this system run 100% indicating that the system is free of bugs.
Penerapan Metode SAW untuk Perancangan SPK Penerimaan Karyawan Di PT Pinnacle Apparels
Authors: Novianto Sendi , Panca Hutama Caniago  , Pulung Nurtantio Andono
Published: September 2024

A company cannot grow without the support of its employees as one of its pillars. Therefore, the company needs to recruit potential and talented candidates who can contribute to its success. Skilled employees who can help the company grow and compete with the changing times are now receiving special attention, as recruitment processes that do not meet the company's needs can hinder its development. Hence, a decision support system is needed for the employee selection process. This decision support system utilizes the Simple Additive Weighting (SAW) method. Candidates are compared to each other, resulting in a prioritized intensity value that assesses each candidate. This decision support system simplifies the evaluation of each candidate and allows for changes in criteria and weight values. This decision support system is beneficial for facilitating decision-making related to the selection of suitable candidates, ensuring that the company hires the most suitable employees
Pembuatan Kursi Antropomteri Berbasis Sensor Hc-Sr 04
Authors: Hapyansyah Dio , Sari Resy Kumala , Musridho Raja Joko
Published: September 2024

The industrial revolution is currently entering the industrial 4.0 stage where it is experiencing its peak, with the birth of digital technology which is very useful for human life throughout the world. The Industrial Revolution 4.0 is colored by artificial intelligence, super computers, genetic engineering, nanotechnology, automatic cars and innovation. the data used in making anthropometric chairs is secondary data. This data is obtained from research that has been carried out by previous studies using the House of Quality (HOQ) method. The data taken is in the form of sketches and product designs for anthropometric chairs based on the HC-SR04 sensor. Making anthropometric chairs using the Operation Process Chart (OPC) Diagram Using the HC-SR04 sensor-based anthropometric chair is faster and more accurate when taking measurements of the human body compared to using a meter or manually
Analisa Pengaruh Kerapatan Udara dan Tegangan Kritis Kawat Penghantar Terhadap Rugi Rugi Daya Corona Sutet 275 kV
Authors: Alfajri Dio
Published: September 2024

This research aims to calculate the effect of the condition of the conducting wire on the 275 kV corona power losses in the Kiliran Jao - Payakumbuh area. This calculation aims to obtain the value of the power losses caused by air density and critical voltage. It can be explained that the value of power losses that occur during one year from August 2022 to July 2023 where the value of power losses varies from 4.94 KW/km to 4.23 KW/km. Where in August 2022 the power loss value is 4.49 KW/km, in September 2022 the power loss value is 4.36 KW/km, in October 2022 the power loss value is 4.23 KW/km, in in November 2022, the power loss value is 4.36 KW/km, in December 2022, the power loss value is 4.49 KW/km, in January 2023, the power loss value is 4.57 KW/km, in February In 2023, the value of power loss was 4.57 KW/km, in March 2023, the value of power loss was 4.81 KW/km, in April 2023, the value of power loss was 4.94 KW/km, in May 2023, the value of power loss loss is 4.81 KW/km, in June 2023 the value of power loss loss is .57 KW/km, in July 2023 the value of power loss loss is 4.57 KW/km. Based on the calculation above, it can be concluded that if If the critical voltage value increases, the power loss value will decrease and if the critical voltage value increases, the power loss value will decrease.
Implementasi Sistem Antrian Digital Di Kantor Kecamatan Winongan Kabupaten Pasuruan
Authors: Satunggale Kurniawan  , Rahman Muhammad Afifi , Rusmini
Published: September 2024

Penelitian ini bertujuan ingin mengungkap permasalahan  Pelayanan  Terpadu ( PATEN ) yang ada di Kantor Kecamatan Winongan  Kabupaten Pasuruan dengan sistem antrian  MANUAL. Dari beberapa informasi yang di himpun dari masyarakat yang mengantri Pelayanan dengan sistem antrian manual  kurang efektif  dan efisiIen. Sehingga untuk memenuhi kebutuhan pelayanan masyarakat yang baik , Instansi Kantor Kecamatan perlu adanya inovasi sistem antrian DIGITAL. permasalahan  Pelayanan  Terpadu ( PATEN ) yang ada di Kantor Kecamatan Winongan  Kabupaten Pasuruan dengan sistem antrian  MANUAL. Dari beberapa informasi yang di himpun dari masyarakat yang mengantri Pelayanan dengan sistem antrian manual  kurang efektif  dan efisiIen. Sehingga untuk memenuhi kebutuhan pelayanan masyarakat yang baik , Instansi Kantor Kecamatan perlu adanya inovasi sistem antrian DIGITAL.. Inovasi merupakan peralihan dari prinsip-prinsip, proses dan praktik-praktik manajemen tradisional atau pergeseran dari bentuk organisasi yang lama ke manajemen modern. Pelayanan Pemerintah kepada masyarakat yang dikenal dengan sebutan pelayanan publik merupakan isu yang sangat strategis karena interaksi antara pemerintah dan masyarakat. Penelitian ini menggunakan pendekatan deskriptif kualitatif dalam rangka mengetahui Inovasi pelayanan publik. Data yang digunakan yaitu data primer dan data sekunder. Teknik pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa inovasi pelayanan publik  dengan sistem antrian Digital adalah inovasi conseptual dimana memunculkan paradigma, ide, gagasan, pemikiran dan terobosan baru. Sedangkan inovasi delivery adalah termasuk cara – cara baru atau dalam menyelesaikan masalah, memberikan layanan atau berinteraksi dengan klien untuk tujuan pemberian layanan khusus kepada pelanggan.
Klasifikasi Kain Tenun Sumba menggunakan Jaringan Saraf Tiruan
Authors: Trisno Trisno , Karolus Wulla Rato  , Adelbertus Umbu Janga  , Robertus Tamo Ama  , Robinson Datu Reja
Published: September 2024

The evaluation results with epoch 100 have quite good classification accuracy. The correct accuracy value of the classification is 60% of the test data. In other words, the results of this classification can be said to be good. Compared with the classification accuracy at epoch 100, which is 20-30% of the test data. The model obtained is good. At epoch 400 this model has a better level of accuracy than epoch 100. At epoch 1000 the increase in recognition accuracy for test data increases by 20% so that the recognition accuracy becomes 55-60%. Based on the results of research using the backpropagation neural network algorithm, there are several different levels of accuracy, the training and validation accuracy values ​​are quite good. The researcher's suggestion is to continue this research so that it can produce a more accurate process. The training process is carried out using several epoch values, namely epoch 200, epoch 400, epoch 600, epoch 800, epoch 1000, epoch. The best accuracy obtained during training was 89.3% and validation was 82%.
Perancangan dan Pembuatan Desain Aplikasi OPNAME dengan Visual Basic Menggunakan Metode UML
Authors: Mohamad Firdaus  , Indra Bakti
Published: September 2024

In a small and medium-sized company PT LUM there is a continuous improvement program so that every division in the company needs to make changes. In the IT division they provide added value to the business by building an inventory application called OPNAME. OPNAME is an information system created to inventory the number of existing IT devices, making this application built with Visual Basic. The design of the application in this study was made using the UML method. by making a Software Design Design (DPPL), then followed by the results of the application interface is expected to make this application user friendly and useful for the company. This process is carried out so that with a good period of time and planning so that it can produce a good product as well. The results of this software are expected to contribute to PT.LUM in the future.
Sistem Informasi Pariwisata Kabupaten Kampar Berbasis Web
Authors: Jaka Prihatna  , Yusnira  , Safni Marwa
Published: September 2024

Tourism is one of the most popular destinations for tourists today, one of the objects and tourist destinations is in Kampar Regency. Kampar Regency is very potential in the tourism sector. Both in the form of historical relics such as the Muara Takus Temple, the Koto Panjang Hydroelectric Reservoir, the Jami Mosque in Kampar District, and many other tourist objects that are quite interesting to visit. However, the problem faced is that there is still limited information to tourists about tourist objects, the current information conveyed from the website and from a blog is very limited. It is hoped that this web-based tourism information system can make it easier for the public to get information about the location of tourist objects in Kampar Regency. The programming language used is PHP Framework Laravel and MySQL as database storage media.
COMMUNITY CHARACTERISTICS AND CONDITIONS OF SANITATION FACILITIES IN THE MUSI RIVERSIDE SETTLEMENT KELURAHAN SATU ULU PALEMBANG IN 2022
Authors: Priyadi  , Pitri Noviadi  , Serly Wiranda  , Sinthia Khodijah Marpaung  , Tri Ariska Mulia
Published: September 2024

Background: According to data from the Working Group on Development, Housing, Settlements, Water and Sanitation (POKJA PPAS) in 2021, the access to decent sanitation in South Sumatra is still below the National achievement of 77.2%. In facts, the condition of settlements on the banks of the river has gone out of control  cause of unqualified basic sanitation. Methods: The type of research used is a descriptive survey. This research was conducted in March-May 2022. The population of this study were all 315 households in Kelurahan Satu Ulu located on the banks of the Musi river. The sample of this study was communities on the banks of the Musi River, Kelurahan 1 Ulu totaling 76 respondents. The sampling technique is Probability Sampling with the Proportionate Stratified Random Sampling method. Results: Of the 76 respondents, high education 47 (61.8%), low education 29 (38.2%), formal livelihoods 5 (66%), non-formal livelihoods 71 (93.4%) low income 41 (53.9%), medium income 35 (46.1%), clean water qualified 33 (43.4%), clean water are not eligible 43 (56.6%) family latrine are eligible 41 (53.9%), family latrine are not eligible 35 (46.1%), wastewater sewers are eligible 27 (35.5%), wastewater sewers are unqualified 49 (64.5%) garbage reservoirs are eligible 40 (52.6%), waste shelters are not eligible 36 (47.4%). Conclusion: Clean water, family latrine, wastewater sewers are in the unqualified category while garbage shelters are included in the eligible category.
FACTORS RELATED OF COVID-19 IN THE WORK AREA OF THE MAKASAR DISTRICT HEALTH CENTER
Authors: Nadratul Laila  , Asyifa Robiatul Adawiyah  , Izattul Azijah  , Nur Apriyan
Published: September 2024

COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 can be transmitted to all age groups, but the elderly who have previous diseases such as cardiovascular disease, diabetes, hypertension, and chronic obstructive pulmonary disease will worsen the COVID-19 disease. Therefore, factors related to COVID-19 are needed to prevent and control COVID-19. The purpose of this study was to determine the factors related to the incidence of COVID-19 in the working area of ​​the Makassar District Health Center in 2021. This type of research was descriptive cross-sectional. The population of this study is the community in the Makassar District Health Center with a sample of respondents aged 17-60 years with a total of 140 respondents. The sampling method was using consecutive sampling techniques through an online google form questionnaire. Data collection was carried out on 23 June -1 July. Data analysis used univariate and bivariate analysis. The results showed that most of the respondents had good knowledge, family roles, behavior, and lifestyle. There is a relationship between gender (p-value = 0.048), education (p-value = 0.014) and behavior (p-value = 0.040) with the incidence of COVID-19. While the unrelated factors are age, occupation, income, comorbidities, BMI status, knowledge, family roles, and lifestyle. It is hoped that the public health center will maximize health promotion and 3T, hold socialization of the distribution of masks, vitamins, and other drugs to increase immunity.
ASSOCIATION BETWEEN RESPIRATORY COMPLAINTS AND PM 10 CONCENTRATION IN HOUSEHOLDS IN PALEMBANG
Authors: Ameria  , Maksuk Maksuk , Amar Muntaha
Published: September 2024

Background: Acute Respiratory Infections (ARI) cause around 4 million under-five deaths in developing countries, including Indonesia. Air quality is strongly influenced by human activities. Purpose: This study was to analyze the relationship between PM10 concentrations in the house and the risk factors for the health conditions of the household environment and human characteristics on the incidence of respiratory disorders. Methods: This research is an analytic observational with a cross-sectional design. The number of samples calculated as many as 60 respondents were taken randomly. This research was conducted in Pulokerto Village, Gandus District, Palembang from August to December 2009. Data were collected through observation and interviews using a questionnaire, while indoor air samples were measured using the EPAM 5000 instrument by BTKL PP Palembang officers. Data were analyzed by univariate, bivariate using chi-square test, and multivariate using multiple logistic regression. Results: The results of statistical tests showed that the usage of insect repellent (p v = 0.0005, OR = 13.095, 95% CI = 3,821-44,882), smoking habits (p v = 0.0005, OR = 15.536, 95% CI = 3.114-77.519), Indoor PM10 concentration (pv=0.021, OR=3.463, 95% CI (1.186 – 10.108) While the most dominant variable affecting respiratory disorders is the usage of insect repellent. Conclusion: The factors that have the greatest influence in causing respiratory disorders are age, gender, education, population density and the use of mosquito repellent.
RISK QUOTIENT OF ZINC (Zn) AND CHROMIUM (Cr) LEVEL IN DUG WELL WATER IN THE COMMUNITY LIVING AROUND LANDFILL SITE
Authors: Maksuk Maksuk , Dewi Ulfa Oktarini  , Tria Effrilia Harahap  , Maliha Amin  , Maya Sopianti  , Khairil Anwar  , Kamsul Kamsul
Published: September 2024

ABSTRACT
Background: Zinc and chromium are heavy metals that can contaminate community-dug well water that is used by people around landfills, and can cause public health problems. This study aimed to analyze the risk level of zinc (Zn) and chromium (Cr) content in the dug well water of the community around Sukawinatan landfill site. Methods: This research was an observational study using a cross-sectional design with an environmental health risk analysis approach, It was conducted in February–May 2021. The sample was water from the dug wells of the community that lives around the Sukawinatan landfill. The examination of zinc and chromium level in dug well water was used the Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES) method. Results: Zinc and chromium level in community dug well water was found to range from 0.03 mg/l to 0.09 mg/l for zinc concentration and from 0.0030 mg/l to 0.04 mg/l for chromium concentration, respectively. The results of calculating the potential dose (intake) for the two metals are still below the dose reference value, and for calculating the level of risk, the result is less than 1, which can be interpreted as not being risky.  Conclusion: Zinc and chromium level in the community's dug-well water around the landfill site was still below the quality standard. The potential dose (intake) and Risk Quotient were safe for the next few years.
FACTORS RELATED TO THE INCIDENCE OF HYPERTENSION IN NON-MEDICAL WORKERS AT X BOGOR HOSPITAL
Authors: Eriskadevi Evri , Mugi Wahidin  , Ade Heryana  , Susi Shorayasari
Published: September 2024

Background: Hypertension is a degenerative disease that is a severe problem in the world. Hypertension is categorized as a silent killer disease because sufferers do not know they have hypertension. According to the World Health Organization (2021), 42% of sufferers are unaware of having hypertension because it often occurs without complaints. Purpose: The purpose of this study was to determine whether there is a relationship between age, gender, family history, smoking habits, and obesity with the incidence of hypertension. Methods: The type of research conducted was quantitative with a cross-sectional approach. The sample size obtained from the results of the study was 58 samples. The research took place in April - July 2023. The instruments used in this study were questionnaires and digital tensimeters to measure blood pressure. The data results are presented in the form of univariate and bivariate analysis using the chi-square test.  Results: The results showed that age (p=0.047), gender (p=0.015), family history (p=0.007), and obesity (p=0.019) showed a significant relationship with the incidence of hypertension. However, smoking habit (p=0.634) did not establish a significant relationship. Conclusion: age, gender, family history, and obesity showed a significant relationship with the incidence of hypertension, and smoking habit did not establish a significant relationship with the incidence of hypertension.
THE FACTORS ASSOCIATED WITH THE IMPLEMENTATION OF COVID-19 VACCINE 3 AT PUBLIC HEALTH CENTER IN OGAN KOMERING ULU DISTRICT
Authors: Aprilianti Putri  , Eka Joni Yansyah  , Sabtian Sarwoko  , Fera Novitry
Published: September 2024

ABSTRACT
Background: A new type of Corona virus (Covid-19), also called Severe Acute Respiratory Syndrome Corona Virus 2, was discovered in humans in Wuhan, China. Covid-19 vaccination can form herd immunity in society, thereby reducing morbidity and death rates due to Covid-19. This researcher aims to determine the analysis of factors related to the implementation of the COVID-19 vaccine in Sukanegeri Village, the UPTD Working Area of the Betung Community Health Center, East Oku Regency, in 2023. Method: This research design uses analytical observation with a cross-sectional approach. The sample was taken from the total population, namely all people who had received the 2nd COVID-19 vaccine in Sukanegeri village, the UPTD Working Area of the Betung Community Health Center, East Oku Regency, totaling 1,554 people, so the sample size was 90.47 (rounded to 91) respondents. The statistical test used is the chi-square test. Results: The results of the bivariate analysis show that, there is a significant relationship between education and the implementation of the 3 covid-19 vaccine with a p value of 0.000, there is a significant relationship between knowledge and the implementation of the 3 covid-19 vaccine with a p value of 0.000, there is a significant relationship between attitude with the implementation of the 3 covid-19 vaccine with a p value of 0.000, there is a significant relationship between the availability of information and the implementation of the 3 covid-19 vaccine with a p value of 0.001, there is a significant relationship between family support and the implementation of the 3 covid-19 vaccine with a p value of 0.001. Conclusion: There is a significant relationship between education, knowledge, attitudes, availability of information, and family support for the COVID-19 vaccine.
FACTORS ASSOCIATED WITH THE INCIDENCE OF TYPE 2 DIABETES MELLITUS IN WOMEN AT THE PEJUANG HEALTH CENTER BEKASI CITY IN 2023
Authors: Maydyani Oletha , Yoli Farradika
Published: September 2024

Background: The 2018 Riskesdas results show that the proportion of diabetes mellitus cases in women (1.8%) is higher than the 2013 Riskesdas results (1.7%). Data obtained from the Pejuang Health Center also shows that type 2 DM cases in women are higher in 2022 with 1,661 cases compared to 2021 with 1,454 cases. Purpose: The purpose of this research was to determine factors associated with incidence of type 2 diabetes mellitus in women at the Pejuang Health Center Bekasi City in 2023. Methods: Research design used quantitative analysis with a case control approach. This research was from February to July 2023. Population in this study were women who came for screening non-communicable disease at the Pejuang Health Center. Number of samples based on the formula is 94 respondents with a sampling technique using purposive sampling. Data source from secondary data thats monthly report data Pejuang Health Center and primary data. The analysis used was univariate and bivariate analysis with Chi-Square test. Results: The results showed that there was a relationship between hypertension (p=0.007), physical activity (p=0.039), and obesity (p=0.011) with the incidence of type 2 DM in women. There was no relationship between a history of gestational diabetes mellitus (GDM) (p=0.410) and a history of giving birth to babies ≥ 4000 grams (p=1.000) with the incidence of type 2 DM in women. Conclusion: Therefore, people who are obese can start doing weekly physical activity, such as taking part in gymnastics activities held by the Pejuang Community Health Center.
THE FACTORS RELATED TO OBESITY IN EAST JAKARTA CITY WORKERS
Authors: Mannulang Debora anastas agnesia
Published: September 2024

Background: Obesity or commonly known as being overweight is a medical condition in which the body has excess fat which has accumulated negative effects on health. Obesity from a health perspective is a disease of malnutrition, as a result of consuming food that far exceeds one's needs. This study aims to determine the factors associated with the incidence of obesity in workers at PT X City of East Jakarta in 2023. Methods: This study used a quantitative approach with a cross-sectional study design. The population in this study were 75 workers and the sample used was 75 respondents with a total sampling technique. Results: The data will be analyzed using the chi-square test with the results showing that there is a significant relationship between age (p-value = 0.030), nutritional adequacy (p-value = 0.0005) and physical activity (p-value = 0.016). While the variable that has no significant relationship is gender (p-value = 0.896). Conclusion: Obesity was related to age, nutrition adequacy and physical activity.
THE RELATIONSHIP BETWEEN OUTDOOR MEDIA ADVERTISING, COUNSELING FOR COUNSELING TEACHERS, AND PEERS ON SMOKING BEHAVIOR AMONG STUDENTS AT STATE VOCATIONAL SCHOOL
Authors: 0marisa_oktavi4 Marisa
Published: September 2024

ABSTRACT
Background: Smoking is still one of the biggest health problems. This habit is a risk to global health and can cause human death. Apart from that, smoking can also result in other health risks related to chronic diseases such as heart attacks, strokes, chronic obstructive pulmonary disease, emphysema, and cancer.This researcher aims to determine the relationship between outdoor media advertising and counseling from tutors and peers on smoking behavior among students at SMK Negeri 3 Oku in 2023. Method: This research design uses observational analytical research with a cross-sectional approach where data for both variables are collected at the same time. or at one time.In this research, the researcher will look for the relationship between outdoor media advertising, guidance counselors, and peer counseling on smoking behavior among students at SMK Negeri 3 Oku East Baturaja in 2023, totaling 876 students, so the sample size used in this study uses a finite sample size formula of 86.65 (rounded to 87) respondents. The statistical test used is the chi-square test.Results: The results of the bivariate analysis show that there is a significant relationship between outdoor media advertising and smoking behavior with a p value of 0.001, a significant relationship between counseling teacher counseling and smoking behavior with a p value of 0.000, and a significant relationship between peers and smoking behavior with a p value of 0.000. Conclusion: There is a significant influence on outdoor media advertising. Counseling guidance counselors and peers with smoking behavior.
THE FACTORS RELATED TO COMPLIANCE WITH THE CONSUMPTION OF BLOOD SUPPLEMENT AT SENIOR HIGH SCHOOL IN LAHAT REGENCY
Authors: Nurhayani Delvi , Maksuk Maksuk , Minarti Minarti
Published: September 2024

Background : Consuming blood supplement tablets is an effort to prevent anemia in young women. The research aims to analyze the compliance of young women in consuming blood supplement tablets. Methods : This research was conducted at high schools in Lahat district in 2023. The calculated sample size was 192 respondents. Data was collected through interviews using questionnaires and analyzed using univariate, bivariate and multivariate methods. Results : The results of the chi - square test obtained variables that were related to compliance with the consumption of blood supplement tablets in young women, namely knowledge, attitudes, exposure to information and availability of iron tablets. Meanwhile, the most dominant factors influencing adolescent girls' compliance in consuming blood supplement tablets are knowledge (pv=0.0005), attitudes (pv=0.005), information exposure (pv=0.043), and availability of iron tablets (pv=0.005). Conclusion : Compliance with consuming blood supplement tablets in young women is related to knowledge, attitudes, exposure to information and availability of iron tablets.
Telomeres, Sirtuins and NAD+ ---- The Genetic Communication at the Ends
Authors: Allauddin Aisha
Published: September 2024

Abstract Telomeres, Sirtuins and NAD+ are all implicated in the aging process. Telomeres are repeating nucleoprotein sequence found at the ends of chromosomes. Sirtuins regulate telomere length by localizing to telomeres. A decrease in NAD+ level as aging progresses has been demonstrated by many clinical studies. An understanding of shortening of telomere leads to suppression in Sirtuin activity as well as decrease in NAD+ and vice versa, suggesting interlinking of their pathways. The positive effects of NAD+ on the aging phenotype are partially assumed to be attributed to Sirtuins. Data was collected by selecting 43 articles by searching through keywords; Telomeres, p53, Sirtuins, NAD+, aging, age-related diseases, genomic stability, Sirtuin activation, in search engines like google scholar and PubMed. The purpose of this review was to find out the functional linking among telomeres length Sirtuins and NAD+, which can help in future studies to improve the therapy options for possible age associated diseases.
Black Cumin and Garlic Induced Cell Death in Hepatoma Cancer Cells (Huh-7)
Authors: Sani Aliya , Azhar Farah
Published: September 2024

Abstract Background: Various plant products have been shown to limit proliferation in cancer cell lines by inducing apoptosis and cell cycle arrest. Objective: The study aimed to assess the growth inhibitory synergistic and solitary effects of black cumin and garlic on Hepatoma cell lines (Huh-7). Methods: Huh-7 hepatoma cells were treated with 10 g of ground black cumin, 10 g of ground garlic, individually, or in combination, and compared to water (control). After 32 hours, cell death was assessed using acridine orange staining under a fluorescent microscope. Cell necrosis was quantified by examining multiple high-intensity fields per slide. Results: Black cumin, garlic induced cell death in Huh-7. To determine alive/dead cell density, high intensity fields per slide, randomly selected after 32 hours of incubation. At magnification of 20x, the controls show 96.2% alive cells compared to 20.0% in garlic, 55.0% in black cumin and 50% in their mixture. However, at 40x magnification, 95.2% alive cells were seen in controls compared to only 20.0% in garlic, 18.0% in black cumin and 23.8% in their mixture. Conclusion: It is concluded that black cumin, garlic, and its mixture exhibit promising anticancer properties against hepatoma cells. In cases of individual cell death or death in limited number of cells, the apoptotic pathway may be involved. However, in cases where cell death was observed in group of cells as well as confluent areas containing dead cells, it is the process of necrosis that may be the mechanism behind the observed effects.
Influence of Parents Socioeconomic Status on Newborn Telomere Length
Authors:   Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan, Farrukh Sadia
Published: September 2024

Background: Telomeres, the marker of biological aging, are substantially influenced by parental untoward exposures and their socioeconomic status (SES). This study aimed to find the association between parents–newborn leukocyte telomere length (LTL) among different SES highlighting reprogramming during fetal life. Methods: The parents' and newborn blood samples (n = 612, 204 each) were collected from September 2021 and July 2022, from Ziauddin Hospitals, Karachi. The real time PCR was used to quantify telomere length (T/S ratio). IBM statistical package for the social sciences (SPSS) was used to carry out analyses and graphs were formed by using GraphPad prism. A P-value of <0.05 was considered statistically significant. Results: The mean age of mothers range between 25-35 (27.5%) and fathers <25 years (55.9). The mothers and their newborns in the upper middle SES had significantly longer LTL (2.7±1.30, 2.14±1.39, p<0.001). Whereas low SES group showed insignificant difference between (Newborn vs. mother). Among father newborns upper middle and high SES groups showed significant differences in TL (p=0.001). Longer TL was seen in father-newborn of the upper middle group (2.69+1.37; 2.79+1.30) with significant difference (p=0.001). Conclusion: Newborns had longer TL compared to their parents, highlighting the in-utero reprogramming in all socioeconomic groups. These findings show the importance of risk factors and their comprehensive understanding and their significance in contributions during vital beginning period of newborns' TL.
Exploring the Resistance Pattern of Salmonella Typhoidal Species
Authors:   Department of Pathology, Fazaia Ruth Pfau Medical College, Karachi, Pakistan, Mehdi Rehana , Irfan Zona ,   Department of Pathology, Fazaia Ruth Pfau Medical College, Karachi, Pakistan, Qamar Nazia ,   Department of Pathology, Fazaia Ruth Pfau Medical College, Karachi, Pakistan, Rehman Ambreen ,   Department of Pathology, Fazaia Ruth Pfau Medical College, Karachi, Pakistan, Nusrat Nadeem ,   Department of Pathology, Fazaia Ruth Pfau Medical College, Karachi, Pakistan, Haider Ali ,   Department of Pathology, Fazaia Ruth Pfau Medical College, Karachi, Pakistan
Published: September 2024

Background: Enteric fever/ typhoid, an infection caused by Salmonella enterica serovars: typhi and paratyphi, is continuously increasing with the emergence of antibiotic resistant Salmonella. According to WHO, an estimated 110,000 people die from it every year. Objective: The primary objective of this study was to investigate the antibiotic susceptibility pattern of typhoidal Salmonella species in blood cultures of patients. Methodology: This was a cross-sectional study, executed at Microbiology Laboratory (Diagnostic Centre), PAF Hospital Faisal Base Karachi, from August 2023 to March 2024. Salmonella typhi in all clinically suspected cases of typhoid fever was identified through conventional techniques following standard microbiological protocols. Assessment of antibiotic susceptibility was performed by Kirby-Bauer disk diffusion method. Results: Out of 1178 blood samples culture 54 were gram positive bacteria, 193 were gram negative bacteria and 931 samples showed no growth. Among the gram-negative sample, 140 tested positive for Salmonella enterica typhoidal species. API 20E was used to further differentiate and identify the Salmonella species, 131 cases were Salmonella typhi and 9 paratyphi. Out of 140 Salmonella isolates, 77% (108) were resistant to ampicillin, 49.2% (69) to Ceftriaxone, 35% (49) to Sulfamethoxazole, and 47% (66) to Ciprofloxacin. Azithromycin and Meropenem remained sensitive in all 140 isolates of Salmonella typhoidal species. Conclusion: This study identified the susceptibility profiles of Salmonella typhoidal species. Our findings underscore the importance of continuous surveillance and judious use of antibiotics to combat the emergence of antibiotic –resistant strains. Further research is warranted to continuously monitor and adapt treatment protocols in response to evolving resistance in Salmonella typhoidal species.
Comparative Analysis of Serum Calcium and Phosphorus Levels: Cord Blood vs. Maternal Blood
Authors: Bhatty Afreen , Fawad Bina , Hardasani Vanshika
Published: September 2024

Abstract Background: The fetal demand for calcium and phosphorus is nearly inexhaustible, with the placenta transporting these minerals from the mother to meet the growing needs of the fetus. Objective: To compare the status of calcium and phosphorus in cord blood versus maternal blood and assess the impact on maternal metabolism in coping with increased demands. Methodology: After obtaining verbal consent, blood samples (n=104) were collected from mothers and the umbilical cord at the time of delivery in the maternity ward of JPMC. Serum calcium was analyzed using the Boehringer kit method, and phosphorus was estimated via atomic absorption spectrophotometry (Hitachi Z-8000). Statistical analysis was performed using SPSS version 20. Results: The mean age of pregnant mothers was 25.3 ± 6.182 years, while the mean age of controls (n=24) was 25 ± 2.1 years. Among neonates, 42.9% (n=21) were female, and 57.1% (n=28) were male, with a mean weight of 2.99 ± 0.63 kg. The mean cord serum calcium was 8.69 ± 0.28 mg/dl, while maternal serum calcium was significantly lower at 8.13 ± 0.40 mg/dl (p<0.01) compared to controls (10.52 ± 0.6 mg/dl). Cord serum phosphorus levels were significantly higher than maternal levels (p<0.0001). A statistically significant negative relationship was found between the weight of the baby and maternal calcium level (r = -0.352, p = 0.024), but not with cord calcium or maternal/cord phosphate levels. Conclusion: Mothers with low serum calcium concentration had correspondingly lower cord blood calcium levels compared to controls, despite compensatory mechanisms. However, the mean concentration of phosphorus in cord blood was significantly higher compared to maternal blood and controls.
Stress and its Correlates among Medical Students in Gambat Medical College
Authors: Kumar Vineet , Fatima Tehreem , Ahmed Usama , Khemani Sandhya , Jalbani Sajal , Noor Kahif , Iqbal Areesha , Memon Muhammad
Published: September 2024

Abstract Background: The immense workload on undergraduate medical students may cause favorable or unfavorable stress, leading to positive or negative consequences. This study was designed to determine the frequency of stress, anxiety, and depression among the undergraduate students of Gambat Medical College. Methodology: 300 students from various academic years, from the first to the final year of MBBS, were selected from Gambat Medical College, Khairpur, following inclusion and exclusion criteria. The Perceived Stress Scale Questionnaire-10 (PSSQ-10), a widely used tool for measuring perceived stress, was utilized to gather data. Stress levels were categorized as low (0-13), moderate (14-26), or high (27-40). Data Analysis was done using SPSS. Percentage, mean, and standard deviation of stress levels were calculated and compared across different academic years. Results: Out of 300 MBBS students, 60 (20%) were from each year, that is, first, second, third, fourth, and final year. Females were 100 (33.33), and males were 200 (66.66). The demographic profile showed 4 (1.33%) students were married (all males). The average age of participants was 21.05 years. 109 (36.22%) students had low stress, 171 (56.9%) had moderate, and 20 (6.65%) had high stress. Overall 41.5% males and 25% females had low stress, 44.5% of males had moderate stress compared to 62% of females. High stress was observed in 3.5% of males compared to 13% of females, three times higher than in males. Significant variations were observed in the second year (p = 0.053), third year (p = 0.007), and fourth year (p = 0.055), implying that gender impacts stress levels during those academic years. Conversely, no significant distinctions were observed in the first and fifth years (p = 0.929 and 0.329, respectively). Conclusion: The data analysis found that students from all academic years reported moderate stress levels. Female students reported considerably greater stress levels than male counterparts, with a pronounced difference (p =0.00066). These findings underscore the need for gender specific interventions to address stress among medical students, which could potentially improve their mental health and academic performance.
Unraveling a Rare Dermatological Conundrum: Bullous Pemphigoid Unveiled in a Pediatric Patient with a Familial Twist
Authors: Akbar Iqra , Jehangir Fatima , Sultana Talat , Bijarani Nawab
Published: September 2024

Bullous Pemphigoid is an autoimmune, blistering skin disorder that is rarely seen in infants and children. Diagnosing Bullous Pemphigoid in children is challenging due to its rarity in this age group. Bacterial and parasitic infections can trigger bullous and blistering lesions in individuals with underlying Bullous Pemphigoid. We report a 5-year-old child who presented with pruritic blisters and bullous lesions, initially attributed to scabies. Porphyria Cutanea Tarda was also considered based on blistering skin and family history. Although immunofluorescence studies were not performed, the diagnosis of Bullous Pemphigoid of Childhood was confirmed through skin biopsy. The patient was treated with corticosteroids after addressing the scabies infection. This case highlights the importance of a comprehensive diagnostic approach in distinguishing between autoimmune and infectious skin condition.
Primary Small Cell Carcinoma of the Breast Combined with Invasive Ductal Carcinoma 1
Authors: Kulsoom Ome
Published: September 2024

Primary small cell carcinoma of the breast (SmCC) is a rare type of breast cancer and a histological subtype of neuroendocrine breast cancer. There is no standard treatment method, and the prognosis is unknown. It needs to be differentiated from lung metastases. A case of a 52-year-old woman is reported here who was diagnosed with small cell carcinoma combined with invasive ductal carcinoma. Whole-body PET-CT and enhanced MRI of the adrenal glands excluded any other primary disease. The patient received an adjuvant chemotherapy regimen of anthracycline combined with cyclophosphamide, sequential cisplatin, and paclitaxel. The patient was kept under close observation for any changes. This case report reviews the literature on SmCC to better understand its pathology characteristics and therapy. Due to the particularity of the patient's tumour composition, we referred to the treatment plan for small-cell lung cancer and adopted a treatment plan based on cisplatin.
Analisis Pengaruh Zakat, Investasi, Nilai Tukar, Bi Rate, dan Pengeluaran Pemerintah terhadap Inflasi di Indonesia Tahun 2009-2019
Authors: Ihsan Budi , Fajar Rahmat , Harris Allan
Published: September 2024

Masalah makroekonomi yang selalu dihadapi suatu Negara yaitu inflasi, dimana pada dasarnya inflasi merupakan kenaikan harga secara umum pada suatu barang yang berlaku dalam suatu perekonomian dari suatu periode ke periode berikutnya. Inflasi sendiri terjadi disebabkan oleh dua hal yang sangat rentan menimbulkan peningkatan inflasi, diantara factor tersebut yaitu Demand-Pull Inflation dan Cost-Push Inflation dimana dua hal tersebut berhubungan dengan zakat, investasi, nilai tukar, BI rate dan pengeluaran pemerintah karena dapat memicu perubahan inflasi.  Penelitian ini bertujuan untuk menganalisis apakah ada pengaruh zakat, investasi, nilai tukar, BI rate dan pengeluran pemerintah terhadap inflasi di indonesia periode 2009-2019. Jenis data yang digunakan adalah data sekunder yang diperoleh dari BPS, BI, Kemendag melalui laporan instansi yang terpublikasikan yang dianalisis menggunakan regresi linear berganda dengan bantuan Program E-Views 10.  Hasil penelitian ini adalah: (1) variabel zakat, investasi, nilai tukar, BI rate dan pengeluran pemerintah secara parsial tidak berpengaruh terhadap inflasi di indonesia periode 2009-2019. (2) variabel zakat, investasi, nilai tukar, BI rate dan pengeluran pemerintah secara simultan tidak berpengaruh terhadap inflasi di indonesia periode 2009-2019. (3) Konsep inflasi dalam padangan islam mengacu pada teori inflasi Al-Maqrizi yang menyatakan bahwa inflasi terjadi bisa terjadi oleh keadaan alamiah dan juga human error serta system yang tidak transparan dan akuntabel. Terjadinya peningkatan inflasi ini dapat diminimalisir dengan konsep zakat melalui demand pull inflasition, sedangkan investasi berperan dalam menekan inflasi melalui cost pust inflation. Disisi lain juga bahwa variable makroekonomi seperti nilai tukar, BI Rate dan Pengeluaran Pemerintah berperan mengendalikan inflasi dengan merapkan konsep islam yaitu larangan riba, maysir dan mengutamakan asas keadilan.
Pengembangan Objek Wisata Taman Bunga dalam Pemberdayaan Masyarakat Desa Jatimulyo Kecamatan Jati Agung Kabupaten Lampung Selatan Menurut Perspektif Ekonomi Islam
Authors: Muji Suwarno
Published: September 2024

The flower garden in the Jati Agung District is one of the tourism assets based on local agro tourism, which is a flower display garden. With this flower garden tour, the Jatimulyo community can be independent without depending on others and can be an opportunity for the local community to help their economy. Therefore, assistance is needed in the form of developing science and technology for the trading community in that place. This type of research includes field research. This research will eventually be analyzed, so the research process raises data from problems in the field relating to the development of flower garden tourism objects in empowering the community of Jatimulyo village, Jati Agung sub-district, South Lampung district according to an Islamic economic perspective. Based on the results of the study, it is known that the impact of developing tourism potential on community economic empowerment in flower garden tourism is the independence of the community in developing self and regional potential for community and regional development. The economic empowerment of the community according to Islamic economics is as the goal of Islamic economics itself, namely all the rules revealed by Allah SWT in the Islamic system that lead to the achievement of goodness and prosperity. Therefore, a flower garden tourism object in a religious view is positive, because it is run in a good way to achieve a good goal as well. Therefore, suggestions that can be given are to the local government of Jatimulyo village and Jati Agung sub-district, it is hoped that they can continue to develop ideas or ideas for the development of tourism objects and can continue to socialize and invite local people to be aware of tourism and can participate in the development of tourism management that can improve tourism. community and regional welfare.
Pengembangan Ekonomi Lampung Berbasis Wisata Halal
Authors: Syahrul  , IMRON
Published: September 2024

Interest in sharia tourism must be responded to by developing sharia tourism businesses in Lampung Province, so that it can help move the economy of Lampung Province. Unfortunately, at this time sharia tourism in Lampung Province itself is still being done half-heartedly. It has been proven that it is only limited to conventional tourism development. If it is done well, it will certainly be a huge opportunity, and it has the potential to boost the country's foreign exchange reserves for the Muslim tourist market of Lampung Province. This study uses a qualitative research approach. The increase in tourist visits shows that Lampung Province has a magnet for tourists who want to visit Lampung Province.  The economic potential of halal tourism in Lampung Province can be seen from pilgrimage, culinary and cultural tourism which can continue to be developed into a lucrative economic potential especially with the support of the government and other elements such as academics and practitioners. The opportunity for halal tourism in Lampung Province is very large because the majority of the population of Lampung Province is Muslim and the increasing number of tourists both local and foreign who come to Lampung Province. At the same time, the tourism potential that is owned is also very much in demand. However, several challenges that Lampung Province must also pay attention to are how then the marketing strategy can be carried out properly and accommodate the interests of other tourists (non-Muslims). Therefore, it is very important to develop halal tourism because its influence is not only on the Islamic economic sector but also a source of state income.
Pengaruh Kinerja Keuangan Perbankan terhadap Return Saham pada saat Pandemi Covid-19
Authors: Nabila Zara Zettira  , Evana Einde , Rizki Eka Putri Widya
Published: September 2024

This study aims to see the impact by Covid-19 on the economic. This study purpose to see the success of various government regulations and policies to contain the negative impacts on the economy as well as to seek economic recovery. The method used in this study is a quantitative research method, while the source of data used in this study is secondary data. This study uses secondary data from the 2019-2021 financial statements. The population in this study are conventional banking companies listed on the Indonesia Stock Exchange. The determination of the sample in this study amounted to 102 using the type of purposive sampling method. The data were analyzed using descriptive statistical tests, classical assumption tests, multiple regression analysis, F test model feasibility, and test T. The results of the research, show that the CAR, BOPO, LDR ratios have a positive influence on stock returns, NPL and ROA have no effect on stock returns, while Economic Conditions have a negative effect on stock returns during Covid-19.