bluuebunny/crossref_metadata_2025 huggingface dataset:
Les enfants terribles de Cocteau et l’Ancien Testament
Authors: Bénard Johanne
Published: September 2017

Je propose dans cet article de relire une scène canonique des Enfants terribles de Jean Cocteau, un roman au riche réseau intertextuel dont on a reconnu déjà (depuis sa parution, chez Grasset, en 1929) les nombreux emprunts au mythe, à la tragédie et à la poésie. Je montre ainsi que la scène où Élisabeth gave son frère endormi avec des écrevisses n’est pas à interpréter seulement par rapport à une symbolique du rêve, mais également par rapport aux interdictions du Lévitique, qui circonscrivent de manière très imagée les oppositions du pur et de l’impur. En faisant intervenir la théorie de Julia Kristeva sur l’abject, qui se réfère aux travaux anthropologiques de Mary Douglas sur la souillure, je suggère que cette scène centrale des Enfants terribles plonge au coeur de l’inceste dans sa version la plus archaïque. L’intertexte biblique de l’Ancien Testament révélerait donc chez Cocteau le sens caché de l’inceste, qui concerne tout autant la relation impure du frère et de la soeur que l’inceste avec la mère, « mythème originaire du texte biblique » selon Kristeva. De même, l’interdit alimentaire biblique mis au premier plan dans cette scène ne serait pas là seulement pour signaler l’inceste, mais la différenciation même du pur et de l’impur à la base de la « cohérence de la structure culturelle », qui a été démontrée par Mary Douglas. Alors que dans l’édition critique de ce roman dans la Pléiade (en 2006), Serge Linares cherche à atténuer le rapport du roman à la perversion (qui serait selon lui contrebalancé par son rapport à la poésie), je montre quant à moi que si nous sommes dans l’impur chez Cocteau, c’est d’abord parce que nous sommes dans l’ordre de l’hybride, de l’inclassable, de l’indifférencié.
Esquives, pièges et désaveux
Authors: Killeen Marie-Chantal
Published: September 2017

« [O]n va leur montrer nos sextes ! » Depuis quarante ans déjà, les écrivaines et réalisatrices de langue française ont répondu en grand nombre à ce cri de ralliement lancé naguère par Hélène Cixous dans son essai « Le rire de la Méduse ». Dans des oeuvres bien souvent provocatrices – où il est question, entre autres, de pratiques sadomasochistes, d’échangisme, de prostitution, de viol, d’inceste –, il importe manifestement d’arracher au silence les expériences les plus diverses de la sexualité féminine. Malgré les accusations de nombrilisme et d’exhibitionnisme que la critique dirige parfois contre ces récits d’aveu, il est d’usage d’interpréter ceux-ci comme signes d’une audacieuse expression de soi et d’une émancipation collective toujours croissante. C’est dans la transgression des tabous, aussi bien que dans l’affranchissement des carcans patriarcaux et hétéronormatifs, que cette entreprise puiserait à la fois sa force personnelle et sa légitimité politique. Les deux oeuvres autofictionnelles sur lesquelles je me concentre ici s’inscrivent toutefois en faux contre cette tendance dominante. Car si Nelly Arcan et Anne F. Garréta se prêtent à des confidences intimes dans Putain (2001) et Pas un jour (2002), c’est pour mieux désavouer la littérature d’aveu. Toutes deux reprennent à leur compte la thèse de Michel Foucault selon laquelle la sexualité, loin d’être sujette à la répression et à la censure, représente à l’âge moderne une source intarissable du discours. Nous serions en définitive constamment adjurés de parler du désir et du plaisir sexuels, l’« ironie de ce dispositif », notait Foucault, étant de « nous fai[re] croire qu’il y va de notre “libération” ». Arcan et Garréta engagent dès lors à se demander si l’injonction actuelle au dévoilement ne relève pas d’une forme insoupçonnée de coercition. En traquant deux des motifs qui animent leurs textes – le scandale dans Putain, la déprise dans Pas un jour –, cette étude s’attache à montrer comment ces oeuvres se constituent en anti-confessions.
THE COLOURED WOMEN’S CLUB OF MONTREAL, 1902-1940
Authors: Este David , Sato Christa , McKenna Darcy
Published: September 2017

To date, there is limited literature documenting contributions of people of African descent to Canadian social welfare history. Based on both secondary and archival sources, we critically explore from anti-Black racism and African-Canadian feminist per\spectives, the contributions of the Coloured Women’s Club of Montreal (CWCM) from 1902-1940 to the social well-being of Montreal’s Black community. The CWCM played a major role as one of the leading supports for members who encountered harsh challenges in a society where racism prevailed and opportunities for men and women were severely restricted. Club members organized several events that enabled community members to survive in an environment that was hostile to people of African descent, therefore becoming a “pillar of strength” that fostered a stronger sense of community among Blacks living in Montreal. We contend that through their contributions during this time period, these African-Canadian women emerged as key players in the community and secondly, as early social welfare practitioners. It is imperative for social workers to acknowledge the contributions of the women who were involved in the CWCM as a means of interrupting the historical narratives shaping our profession that have predominantly been told from the perspectives of a hegemonic, white culture.
Car Equivalents Dependence on the Longitudinal Road Gradient on Two-lane Roads in Bosnia and Herzegovina
Authors: Subotić Marko Miladin , Tubić Vladan Jevđen
Published: September 2017

The main objective of this paper, based upon the extensive empirical research of free flow in local conditions, is to quantify the unfavourable impact of the flow structure on the road capacity using PCE (Passenger Car Equivalent) values as a function of longitudinal grade. Based on literature reviews and empirical research, it has been proved that the PCE value for all vehicle classes is directly correlated with the road gradient. The PCE values in free flow conditions have been determined for the approved vehicle classes. Based on the measured values, models for determining the average PCE value depending on the upward grade on two-lane roads have been developed. Comparison of the developed models in conditions of free traffic flow with the Highway Capacity Manual (HCM) models has shown lower PCE values in this research. Models for the percentage of PCE values PCE15%, PCE50% and PCE85% have also been established.
Co-expression of xenopsin and rhabdomeric opsin in photoreceptors bearing microvilli and cilia
Authors: Vöcking Oliver , Kourtesis Ioannis , Tumu Sharat Chandra , Hausen Harald
Published: September 2017

Ciliary and rhabdomeric opsins are employed by different kinds of photoreceptor cells, such as ciliary vertebrate rods and cones or protostome microvillar eye photoreceptors, that have specialized structures and molecular physiologies. We report unprecedented cellular co-expression of rhabdomeric opsin and a visual pigment of the recently described xenopsins in larval eyes of a mollusk. The photoreceptors bear both microvilli and cilia and express proteins that are orthologous to transporters in microvillar and ciliary opsin trafficking. Highly conserved but distinct gene structures suggest that xenopsins and ciliary opsins are of independent origin, irrespective of their mutually exclusive distribution in animals. Furthermore, we propose that frequent opsin gene loss had a large influence on the evolution, organization and function of brain and eye photoreceptor cells in bilaterian animals. The presence of xenopsin in eyes of even different design might be due to a common origin and initial employment of this protein in a highly plastic photoreceptor cell type of mixed microvillar/ciliary organization.
Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9
Authors: Murase Sachiko , Lantz Crystal L , Quinlan Elizabeth M
Published: September 2017

The sensitivity of ocular dominance to regulation by monocular deprivation is the canonical model of plasticity confined to a critical period. However, we have previously shown that visual deprivation through dark exposure (DE) reactivates critical period plasticity in adults. Previous work assumed that the elimination of visual input was sufficient to enhance plasticity in the adult mouse visual cortex. In contrast, here we show that light reintroduction (LRx) after DE is responsible for the reactivation of plasticity. LRx triggers degradation of the ECM, which is blocked by pharmacological inhibition or genetic ablation of matrix metalloproteinase-9 (MMP-9). LRx induces an increase in MMP-9 activity that is perisynaptic and enriched at thalamo-cortical synapses. The reactivation of plasticity by LRx is absent in Mmp9−/− mice, and is rescued by hyaluronidase, an enzyme that degrades core ECM components. Thus, the LRx-induced increase in MMP-9 removes constraints on structural and functional plasticity in the mature cortex.
Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain
Authors: Remaud Sylvie , Ortiz Fernando C , Perret-Jeanneret Marine , Aigrot Marie-Stéphane , Gothié Jean-David , Fekete Csaba , Kvárta-Papp Zsuzsanna , Gereben Balázs , Langui Dominique , Lubetzki Catherine , Angulo Maria Cecilia , Zalc Bernard , Demeneix Barbara
Published: September 2017

In the adult brain, both neurons and oligodendrocytes can be generated from neural stem cells located within the Sub-Ventricular Zone (SVZ). Physiological signals regulating neuronal versus glial fate are largely unknown. Here we report that a thyroid hormone (T3)-free window, with or without a demyelinating insult, provides a favorable environment for SVZ-derived oligodendrocyte progenitor generation. After demyelination, oligodendrocytes derived from these newly-formed progenitors provide functional remyelination, restoring normal conduction. The cellular basis for neuronal versus glial determination in progenitors involves asymmetric partitioning of EGFR and TRα1, expression of which favor glio- and neuro-genesis, respectively. Moreover, EGFR+ oligodendrocyte progenitors, but not neuroblasts, express high levels of a T3-inactivating deiodinase, Dio3. Thus, TRα absence with high levels of Dio3 provides double-pronged blockage of T3 action during glial lineage commitment. These findings not only transform our understanding of how T3 orchestrates adult brain lineage decisions, but also provide potential insight into demyelinating disorders.
Coral larvae for restoration and research: a large-scale method for rearing Acropora millepora larvae, inducing settlement, and establishing symbiosis
Authors: Pollock F. Joseph , Katz Sefano M. , van de Water Jeroen A.J.M. , Davies Sarah W. , Hein Margaux , Torda Gergely , Matz Mikhail V. , Beltran Victor H. , Buerger Patrick , Puill-Stephan Eneour , Abrego David , Bourne David G. , Willis Bette L.
Published: September 2017

Here we describe an efficient and effective technique for rearing sexually-derived coral propagules from spawning through larval settlement and symbiont uptake with minimal impact on natural coral populations. We sought to maximize larval survival while minimizing expense and daily husbandry maintenance by experimentally determining optimized conditions and protocols for gamete fertilization, larval cultivation, induction of larval settlement by crustose coralline algae, and inoculation of newly settled juveniles with their dinoflagellate symbiont Symbiodinium. Larval rearing densities at or below 0.2 larvae mL−1 were found to maximize larval survival and settlement success in culture tanks while minimizing maintenance effort. Induction of larval settlement via the addition of a ground mixture of diverse crustose coralline algae (CCA) is recommended, given the challenging nature of in situ CCA identification and our finding that non settlement-inducing CCA assemblages do not inhibit larval settlement if suitable assemblages are present. Although order of magnitude differences in infectivity were found between common Great Barrier Reef Symbiodinium clades C and D, no significant differences in Symbiodinium uptake were observed between laboratory-cultured and wild-harvested symbionts in each case. The technique presented here for Acropora millepora can be adapted for research and restoration efforts in a wide range of broadcast spawning coral species.
Trends in Transcatheter Aortic Valve Replacement Outcomes
Authors: Arnold Suzanne V. , Manandhar Pratik , Vemulapalli Sreekanth , Kosinski Andrzej S. , Batchelor Wayne B. , Thourani Vinod H. , Mack Michael J. , Cohen David J.
Published: October 2024

Importance

Although transcatheter aortic valve replacement (TAVR) outcomes in the US have improved substantially since 2011, it is unknown whether these trends have continued since 2019.

Objective

To examine changes in risk-adjusted TAVR outcomes from 2019 to 2022 and to examine any noteworthy trends over time.

Design, Setting, and Participants

This cohort study examined data from patients with severe aortic stenosis treated with TAVR at 786 US hospitals between January 1, 2019, and March 31, 2022, included in the Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapies (TVT) Registry.

Exposure

Patients who underwent TAVR.

Main Outcomes and Measures

The primary outcome was 30-day mortality, and the secondary outcomes were in-hospital mortality and 30-day composite adverse events. To understand factors explaining these trends, a series of logistic regression models was constructed for each outcome, with time as the primary explanatory variable. After adjusting for changing patent characteristics and procedural factors, a series of exploratory analyses was performed to examine the extent to which these findings could be explained by several plausible hypotheses.

Results

This study’s analytic cohort included a total of 210 495 patients. Median (IQR) patient age was 79 (73-85) years, and 91 313 patients (43.4%) were female. Median (IQR) STS predicted risk of mortality (PROM) was 3.3% (2.0%-5.3%). There were no significant changes in unadjusted 30-day mortality from quarter 1 of 2019 (2.4%) to the end of quarter 1 of 2022 (2.2%) (P for trend = .10), with an unadjusted odds ratio (OR) for time of 0.98 per year (95% CI, 0.94-1.01). After adjusting for patient characteristics, the OR increased to 1.05 per year (95% CI, 1.02-1.08), which increased further after adjusting for procedural characteristics to 1.09 per year (95% CI, 1.05-1.13). In exploratory analyses, there were no meaningful changes in the adjusted odds of death after excluding sites that entered the STS/ACC TVT Registry in 2019 or later (OR, 1.09; 95% CI, 1.05-1.13), low-volume sites (OR, 1.09; 95% CI, 1.06-1.13), low-risk patients (OR, 1.11; 95% CI, 1.07-1.15), patients with a bicuspid aortic valve (OR, 1.09; 95% CI, 1.05-1.13), in-hospital deaths (OR, 1.08; 95% CI, 1.03-1.14), or patients who experienced a major vascular complication (OR, 1.09; 95% CI, 1.05-1.12).

Conclusions and Relevance

In this observational cohort study performing a national analysis of outcomes after TAVR, it was found that risk-adjusted 30-day mortality increased modestly from January 2019 to March 2022. However, no site-level, patient-related, or process-related factors were identified that could explain these findings. Although the absolute increase in risk-adjusted mortality during the study period was relatively small, these findings warrant continued surveillance.
Aortic Stenosis, Heart Failure, and Aortic Valve Replacement
Authors: Mengi Siddhartha , Januzzi James L. , Cavalcante João L. , Avvedimento Marisa , Galhardo Attilio , Bernier Mathieu , Rodés-Cabau Josep
Published: October 2024

Importance

Heart failure (HF) and aortic stenosis (AS) frequently coexist, presenting a complex clinical challenge due to their intertwined pathophysiology and associated high morbidity and mortality. Despite numerous advancements in transcatheter and surgical aortic valve replacement (AVR), HF decompensation remains the leading cause of cardiac rehospitalization and a major predictor of mortality in patients with AS, before or after AVR. This review aims to provide a comprehensive analysis of the interplay between AS and HF, delving into myocardial changes caused by stenotic insult, the impact of AVR on these changes, and the prevalence and contributing elements of HF before and after AVR.

Observations

The prevalence of HF remains high before and after AVR, particularly among patients with left ventricular dysfunction. Increased afterload from AS causes cardiac remodeling, which is initially benign but over time these changes become maladaptive, contributing to HF and increased mortality. The progression of HF is influenced by the degree of reverse cardiac remodeling, which can be affected by comorbid conditions, the hemodynamic performance of the valve prosthesis, and vascular stiffness. Several blood and imaging biomarkers offer insights into underlying AS pathophysiology, serving as mortality predictors and predicting HF in this patient population.

Conclusions and Relevance

HF development in AS is multifactorial and its link to left ventricular dysfunction is a complex process. Delineating the determinants of HF admissions in AS is crucial for identifying individuals at high risk. Identifying the early signs of left ventricular decompensation by using surrogate markers may be the key, even before left ventricular function becomes impaired. Translating multimodality imaging techniques and biomarkers into routine clinical practice for evaluating cardiac damage and integrating these markers with patient and procedural factors that affect HF before and after AVR can facilitate timely intervention, minimizing the likelihood of HF progression and influencing future guidelines.
Lipodermatosclerosis and Pulmonary Hypertension in Systemic Sclerosis
Authors: Davuluri Srijana , Kapoor Puneet , Nandyala Swarna , Li Shufeng , Simard Julia , Lewis Matthew , Fiorentino David , Chung Lorinda
Published: October 2024

Importance

Lipodermatosclerosis (LDS) stems from vascular dysfunction and dermal inflammation and thereby is mechanistically similar to systemic sclerosis (SSc). The association of LDS with SSc in the clinical setting has not been well characterized in the literature.

Objective

To evaluate the prevalence of LDS in SSc and the association of LDS with vascular complications, particularly pulmonary hypertension, in patients with SSc.

Design, Setting, and Participants

This retrospective cohort study used prospectively collected longitudinal data from a cohort of patients from the multidisciplinary rheumatology and dermatology clinic at a single tertiary care center from November 2004 to November 2022. Adult patients (aged ≥18 years at the time of cohort entry) with SSc were included.

Exposure

Clinical diagnosis of LDS based on expert opinion or histopathologic findings.

Main Outcomes and Measures

The main outcomes included prevalence of LDS, the association of LDS with the macrovascular complications, including pulmonary hypertension, digital gangrene and/or scleroderma renal crisis. Disease complications, including cardiac arrhythmias and heart failure, were compared among patients with and without LDS.

Results

Among 567 patients with SSc (494 [87.1%] female; mean [SD] age, 53.4 [14.4] years), 25 (4.4%) had LDS and 542 (95.6%) did not have LDS. Skin ulceration occurred in 8 patients with LDS (32.0%). Patients with LDS had higher frequencies of cardiac arrhythmia (11 of 24 [45.8%] vs 145 of 539 [26.9%]), heart failure (7 [28.0%] vs 55 [10.1%]), and pulmonary hypertension (12 [48.0%] vs 137 of 541 [25.3%]) compared with patients without LDS. Frequency of scleroderma renal crisis and digital gangrene did not differ significantly between patients with and without LDS (0 vs 37 [6.8%] and 4 [16.0%] vs 69 of 538 [12.8%], respectively). Among patients with LDS, 9 (36.0%) were either discharged to hospice or died during follow-up compared with 115 patients without LDS (21.2%). Lipodermatosclerosis was associated with pulmonary hypertension (adjusted prevalence odds ratio, 3.10; 95% CI, 1.33-7.25).

Conclusions and Relevance

In this cohort study, LDS was a rare clinical manifestation in patients with SSc but was associated with pulmonary hypertension. Therefore, patients with LDS should be closely monitored and screened for pulmonary hypertension.
Perspectives on Artificial Intelligence–Generated Responses to Patient Messages
Authors: Kim Jiyeong , Chen Michael L. , Rezaei Shawheen J. , Liang April S. , Seav Susan M. , Onyeka Sonia , Lee Julie J. , Vedak Shivam C. , Mui David , Lal Rayhan A. , Pfeffer Michael A. , Sharp Christopher , Pageler Natalie M. , Asch Steven M. , Linos Eleni
Published: October 2024

This cross-sectional study of patient queries in US electronic health records examines laypersons’ satisfaction with answers generated with artificial intelligence (AI) compared with clinician responses, and whether results were concordant with clinician-determined quality of AI responses.
Utilization of Primary Cytoreductive Surgery for Advanced-Stage Ovarian Cancer
Authors: Bercow Alexandra , Stewart Taylor , Bregar Amy J. , Gockley Allison , Mazina Varvara , Rauh-Hain J. Alejandro , Melamed Alexander
Published: October 2024

This cohort study examines changes in surgical approach for patients with stage III and IV epithelial ovarian cancer from 2010 to 2021.
Open Access Publishing Metrics, Cost, and Impact in Health Professions Education Journals
Authors: Abdel-Razig Sawsan , Stadler Dora , Oyoun Alsoud Leen , Archuleta Sophia , Ibrahim Halah
Published: October 2024

Importance

Publishing in health professions education (HPE) journals is an integral component of academic discourse and career progression. Research in this field is shifting to an open access (OA) publishing model.

Objective

To identify the characteristics and publishing models of HPE journals and explore potential associations between publication costs and journal metrics.

Design, Setting, and Participants

This cross-sectional study was conducted between September 20, 2023, and February 14, 2024, using the World Bank purchasing power parity (PPP) index to analyze relative costs of article processing charges (APCs). Data on journal characteristics, impact metrics, APCs, and waiver or discount were extracted from the National Library of Medicine, Scimago, Scopus, journal websites, and email correspondence with editorial staff of journals. All HPE journals indexed in PubMed, written in or translated into English, and with HPE as a core component of their mission were included in the analysis.

Main Outcomes and Measures

Two-year impact factor, H-index, cite score, Scientific Journal Ranking, and APC.

Results

Among the 51 journals included, 27 (53%) adopted OA-only and 24 (47%) adopted hybrid publishing models. The median (IQR) APC for all journals was $2820.00 ($928.00-$3300.00). Associations were observed between impact factor and APC (β coefficient, $386.84; 95% CI, $226.84-$546.84; P < .001) and between cite score and APC (β coefficient, $282.40; 95% CI, $148.12-$416.61; P < .001). Of 20 journal websites with information regarding fee waivers or discounts, 7 journals (35%) confirmed fee waiver or discount. The PPP index analysis of the top 39 countries publishing HPE research showed that the financial burden of meeting the median APC for publication was 1.94 to 10.26 times higher for authors from lower-income countries than for authors from the US.

Conclusions and Relevance

Results of this cross-sectional study suggest that adoption by HPE journals of an OA publishing model was high but access to APC waivers or discounts was limited. These factors create barriers to equitable OA practices, necessitating concerted efforts, such as increasing transparency of publishing costs, implementing economic impact analysis, expanding waivers to eligible authors, and applying holistic impact factor scoring.
Emergency Care Use During Pregnancy and Severe Maternal Morbidity
Authors: Declercq Eugene R. , Liu Chia-Ling , Cabral Howard J. , Amutah-Onukagha Ndidiamaka , Diop Hafsatou , Mehta Pooja K.
Published: October 2024

Importance

Pregnant individuals who repeatedly use emergency care during pregnancy represent a population who could be disproportionately vulnerable to harm, including severe maternal morbidity (SMM).

Objective

To explore patterns of unscheduled care visits during pregnancy and ascertain its association with SMM at the time of birth.

Design, Setting, and Participants

This cohort study used data from a statewide database that linked hospital records to births and fetal deaths occurring between October 1, 2002, and March 31, 2020, in Massachusetts. Pregnant individuals experiencing births or fetal deaths during the study period were included. Data analysis was conducted from June 2022 to September 2024.

Exposure

The exposure was 4 or more cases of emergency use, defined as either an emergency department visit or observational stay during pregnancy not resulting in hospital admission. Pregnancy episode was ascertained by subtracting the gestational age at birth from the date of birth.

Main Outcomes and Measures

The outcome of interest was the odds ratio (OR) for SMM at the time of birth. The algorithm includes 20 conditions or procedures (excluding transfusion) identified through International Classification of Diseases, Ninth Revision and International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes across the study period.

Results

A total of 774 092 pregnant individuals (mean [SD] age, 31.2 [5.8] years; 16.8% Hispanic, 9.3% non-Hispanic Asian or Pacific Islander, 9.5% non-Hispanic Black, 63.1% non-Hispanic White) with emergency care visits during the pregnancy were included; 31.3% of these individuals had at least 1 visit. Overall, 18.1% had 1 visit and 3.3% had 4 or more visits. Four or more unscheduled visits were common among those younger than age 25 years (8.7%), with Hispanic (5.7%) or non-Hispanic Black (4.9%) race and ethnicity, with public insurance (6.5%), or with a comorbidity (19.0%) or an opioid use–related hospitalization (26.8%) in the year prior to pregnancy. Of those with 4 or more unscheduled visits, 43.8% visited more than 1 hospital during pregnancy. In a multivariable analysis of the likelihood of SMM, those with 4 or more unscheduled visits had an adjusted OR of 1.46 (95% CI, 1.29-1.66) compared with those with 0 visits.

Conclusions and Relevance

This cohort study found that high emergency care use during pregnancy was associated with an increased risk for SMM. With a significant proportion of those with frequent unscheduled visits also using multiple hospitals, solutions that are community-based and integrated across health systems may be most beneficial.
Toward Equitable Interventions in Public Mental Health
Authors: Reininghaus Ulrich , Reinhold Annika S. , Priebe Stefan , Rauschenberg Christian , Fleck Leonie , Schick Anita , Schirmbeck Frederike , Myin-Germeys Inez , Morgan Craig , Hartmann Jessica A.
Published: October 2024

Importance

The field of public mental health is evolving to tackle the profound impact of global challenges such as climate change, migration, and health crises. These issues accentuate health and social inequities, necessitating a focus on how to achieve interventions that are equitable and enhance mental health across all societal strata.

Observations

Population-based interventions can inadvertently exacerbate mental health inequities if they are primarily assessed by, and beneficial to, the most advantaged. Dimensional approaches such as the Hierarchical Taxonomy of Psychopathology offer a more nuanced understanding of mental health, capturing the whole spectrum of symptom severity in a culturally sensitive and less stigmatizing way. In addition, adopting intersectional, participatory, and settings-based approaches can help tailor interventions to the unique needs of marginalized groups.

Conclusions and Relevance

In moving toward more equitable interventions in public mental health, it is imperative to adopt an approach that integrates multiple frameworks to address the complexity of mental health inequities. At the core of this integrated approach is the recognition that mental health exists on a continuum. Intersectionality theory can help to identify the root (fundamental) causes of mental health while participatory and settings-based approaches ensure that interventions are relevant, culturally sensitive, and accessible to all. By adopting these approaches, interventions that are not only effective in “shifting the curve” toward better mental health, but are also equitable in their reach and impact, can be developed.
Entropy Increase in Electrolytes for Practical Anode‐Free Lithium Metal Batteries with High‐Loading Cathodes and Lean Electrolyte
Authors: Hu Fan , Chen Jing , Cao Hongshuai , Wang Haikuo , Guo Hao , Ouyang Xiaoping
Published: October 2024

An effective concept of using entropy increase to regulate the nanoscale solvation structure has been proposed to enhance the cycle performance of anode‐free lithium metal batteries (AFLMBs). It includes two mainstream types: entropy increase driven by multiple salts or solvents. However, most current research is based on low‐loading cathodes and mAh‐level battery systems. The relationship between the increase in entropy and practical battery with different high‐loading cathodes and Ah‐levels is seldom reported. In this paper, two mainstream methods of entropy increase are compared, and the relationship of their kinetics parameters, solid electrolyte interphase formation, and cycling performances are studied. It is found that the entropy increases driven by multiple‐solvents are more favorable to the pouch cell with high‐loading cathode and lean electrolytes. The coin cell consists of a copper current collector and a high‐loading cathode (10.5 mg cm−2) performs 40 cycles at discharge rates of 0.5 C, while the cell with a conventional ester electrolyte only last 10 cycles. A large‐capacity pouch cell (4 Ah), with a high‐loading cathode (7.6 mAh cm−2, single side) and lean electrolyte of 1.3 g Ah−1, achieves 500 Wh kg−1 and 20 cycles.
ALD of Metal Fluorides–Potential Applications and Current State
Authors: Atosuo Elisa , Mäntymäki Miia , Ritala Mikko
Published: October 2024

Metal fluoride thin films are important materials in a multitude of applications. Currently, they are mostly used in optics, but their potential in energy harvesting and storage is recognized as well. Atomic layer deposition (ALD) is an advanced thin film deposition method that has an ever‐increasing role in microelectronics. The assets of ALD are its capability to produce uniform, stoichiometric, and pure films with precise thickness control even on top of complicated structures, such as high aspect ratio trenches. These characteristics can be beneficial in applications of metal fluoride thin films but so far ALD of metal fluorides has remained much less studied and used than ALD of metal oxides, nitrides, sulfides, and pure metals. This review aims to motivate research on ALD of metal fluorides by surveying potential applications for ALD metal fluoride thin films and coatings. The basics of luminescent applications, antireflection coatings, and lithium‐ion batteries will be discussed. Next, the fundamentals of ALD will be presented followed by a comprehensive summary of the metal fluoride ALD processes published so far.
Synergistic Reduction and Oxidation Resistant Interface Modifier for High‐Voltage and High‐Loading Solid‐State Lithium Batteries
Authors: Wu Jiaxin , You Zichang , Li Meng , Chen Huan , Feng Sheng , Wang Lingchen , Yuan Huihui , Jin Jun , Lu Yan , Wen Zhaoyin
Published: October 2024

Solid‐state batteries (SSBs) with high‐voltage cathodes and Li‐anodes offer promising energy density and safety for next‐generation batteries. However, poor contact and electrochemical instability of solid electrolyte interfaces hinder their long‐term performance. Traditional rigid solidification interlayers possess restricted capability to address these issues. Herein, a composite buffer interlayer (CBI) with localized high‐concentration electrolytes (LHCEs) in a flexible polymer scaffold, tackling contact and stability problems and ensuring a perfect interface is developed. The extended electrochemical window provides it with synergistic antioxidation and antireduction capabilities, making it compatible with high‐voltage cathodes and Li anodes, while an in situ formed LiF‐Li3N rich inorganic interface ensures uniform lithium deposition and prevents dendrite formation. This CBI enables lithium symmetric cells to achieve a super high critical current density of 7.2 mA cm−2. Most impressively, coupled with a high‐voltage LiNi0.83Co0.12Mn0.05O2 cathode (NCM83), the full cell achieves 94.1% capacity retention after 125 cycles (coulombic efficiency >99.8%) at a mass loading of 14.6 mg cm−2 and a high voltage of 4.45 V. Additionally, a pouch cell with 17.2 mg cm−2 NCM83 achieves an initial discharge capacity of 3.82 mAh cm−2 an superior cycling stability (75 cycles, 89% capacity retention), showcasing the practical potential of LHCE‐CBI enabled SSBs.
From Local Farms to Supermarket Foods: The Story of the Homogenization of the Argentine Diet Told by the Isotope Ratios of Modern Teeth
Authors: Otero Felipe , Loupias Luciano Lautaro , Mancini Luis Henrique , Bahniuk R Anelize Manuela , Béguelin Marien , Valenzuela Luciano Oscar
Published: October 2024

Objectives

Nutritional changes over the last century, driven by globalization, hypermarketization, and malnutrition, are global in scale. Large countries in the Global South might be resilient to dietary homogenization due to their natural diversity of regions and ecosystems, which might have prevented the adoption of supermarket diets. Argentina has a wide array of ecosystems and historically different subsistence diets dependent on regional characteristics. We analyzed the spatiotemporal variation of stable isotope values in Argentina using modern teeth to test for regional dietary patterns and its consistence over time.

Materials and Methods

We collected teeth from voluntary donors born between 1940 and 2010, from 72 locations across Argentina. A total of 119 teeth were analyzed for the markers δ
13Cdentine, δ
13Cenamel, δ
15N, and δ
34S. A reconstruction of isotopic niches was performed to estimate dietary patterns across different regions and time periods.

Results

This study is the first to analyze changes in modern dietary patterns in Argentina using isotopic data measured in contemporary teeth. We showed latitudinal, longitudinal, and temporal differences in isotopic values, reflecting the variation in available resources within the country. Changes in the diet were observed over time, including declining δ
15N values, a reduction in δ
34S range, and a trend toward homogenization of δ
13Cenamel values. Conversely, δ
13Cdentine values remained constant over time, maintaining latitudinal patterns and regional differences across regions.

Discussion

This study increases our understanding of modern population dietary patterns both spatially and over the last 70 years. Our findings suggest that the Argentine population has shifted toward a supermarket diet in recent years.
Association of MIND diet with cognitive decline among Black and White older adults
Authors: Agarwal Puja , Barnes Lisa L. , Dhana Klodian , Liu Xiaoran , Zhang Yanyu , Beck Todd , Cornelis Marilyn C. , Tangney Christy , Rajan Kumar B.
Published: October 2024

INTRODUCTION

We examined the Mediterranean–Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet's association with cognitive decline by race among older adults in the Chicago Health and Aging Project.

METHODS

Five thousand two hundred fifty‐nine participants (73.5 [± 6.0] years, 62% Black participants, 62% female) completed a food frequency questionnaire, and two or more cognitive assessments over 7.8 ± 4.6 years.

RESULTS

Overall, higher MIND diet was associated with slower cognitive decline (p for trend = 0.0025). The MIND score (range:0‐15) was different between Black and White older adults(6.97 vs. 7.12, p = 0.010). Compared to the lowest tertile, among White participants, the two highest tertiles (MIND score –7: β = 0.0121 [95% confidence interval [CI]: 0.0006, 0.0237]; MIND score –8.5: β = 0.0146 [95% CI: 0.0003, 0.0260]) and among Black participants, only the highest tertile (MIND score –8.5: β = 0.0088 [95% CI: 0.0003, 0.0172]) had association with cognitive decline. Vascular and lifestyle factors attenuated the association only for Black older adults.

DISCUSSION

The MIND diet was associated with slower cognitive decline in Black and White older adults, but this may vary with other lifestyle and vascular factors. Further research is warranted on race‐specific cultural diets considering other risk factors for cognitive decline.

Highlights

The intake of Mediterranean–Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet components varies by race.

The MIND diet may slow cognitive decline in both Black and White older adults.

This association may vary with other lifestyle and vascular risk factors.
Effects of nanosilica and nanocellulose on poly(butylene adipate‐co‐terephthalate) nanocomposites for food packaging applications
Authors: Sant'Anna Andrade Letícia , de Carvalho Silva Gabriela Cristina , de Oliveira Freitas Lione Viviane , da Silva Emerson Oliveira
Published: October 2024

Polymeric materials are highlighted in the global market due to their low cost, excellent properties, and diversity of applications, such as food packaging, which in addition to protecting packaged foods also promotes control and conservation against contaminants. Thus, the objective of this research is to investigate the effects of adding silica nanoparticles and cellulose nanofibers, alone and together, on the properties of poly(butylene adipate‐co‐terephthalate), aiming for application in food packaging. For this purpose, PBAT and the nanofillers were initially mixed in a rheometer to produce masterbatches, and, then, to be processed by a single screw extruder to generate the nanocomposites. The nanocomposites are analyzed by scanning electron microscopy, x‐ray diffraction, thermogravimetric analysis, differential scanning calorimetry, nuclear magnetic resonance, tensile testing, water contact angle, and microbial permeability. In low concentrations, it is observed that the system tends to be less heterogeneous. Nanoparticles do not interfere with thermal stability and present a barrier to microorganisms. Interestingly, in the two conditions studied, polymers with cellulose nanofibers or silica nanoparticles have filtering capacity, being effective as physical barriers to the growth of microorganisms within 60 days. However, the effect on mechanical properties is small, being more pronounced with the use of cellulose nanofibers.
Community college student perceptions of digital anatomy models as a curricular resource
Authors: Baptiste Yvonne M. , Abramovich Samuel
Published: October 2024

Digital model platforms and applications are common in anatomy education and continue to grow in number, which suggests that educators and students find use for these tools despite the lack of widely accepted best practices. Consequently, it is a challenge for educators to mindfully integrate digital models into curriculum. This short‐term, longitudinal study investigated the effects of integrating a monoscopic digital model as a teaching tool during lectures on reproductive and endocrine anatomy as an intervention in a community college human anatomy and physiology course. Student use and perceptions of digital models were analyzed for correlation with the nature of the course content and the intervention (n = 92). Academic content significantly affected self‐reported student use (p < 0.001) as well as student perceived usefulness of the model (p = 0.02). These findings support the conjecture that digital anatomy models may be better for achieving certain specific learning goals opposed to all learning goals. Integration of digital models as an instructional method did not consistently influence student behavior but it made a difference in participant ability to recognize this technology outside of the lecture. Overall, participants had a positive perception of digital models, although they were not perceived as more important than all other curricular resources. Inclusion of monoscopic digital models for teaching anatomy should be considered by educators since teaching with digital models can demonstrate strengths and weaknesses for students within the context the of learning objectives, assisting students to make more informed decisions about effective learning tools.
Structural Characteristics and DNA Groove Binding Abilities of Two Zinc‐Based Isoreticular MOFs
Authors: Chatterjee Taposi , Guha Priyam , Dutta Basudeb , Khan Samim , Siddiqui Masoom Raza , Wabaidur Saikh M. , Hedayetullah Mir Mohammad , Mafiz Alam Seikh
Published: October 2024

In this study, we have synthesized two zinc(II)‐based metal‐organic frameworks (MOFs) designated as [Zn(4‐nvp)(bdc)] ⋅ (MeOH) (1) and [Zn2(4‐nvp)2(bpdc)2] ⋅ (DMF) (2) [4‐nvp=4‐(1‐naphthylvinyl) pyridine, H2bdc=1,4‐benzendicarboxylic acid and H2bpdc=4,4′‐biphenyldicarboxylic acid]. Single‐crystal X‐ray diffraction (SCXRD) of both compounds unveiled an interesting paddle‐wheel [Zn2(O2C−C)4] secondary building block (SBB) composed of dinuclear Zn (II) centers and four dicarboxylate groups with a (4,4) square grid topology. These SBBs are interconnected giving rise to an infinite 2D layer architecture. Notably, the grid structure is composed of MeOH molecules in compound 1 and DMF molecules in compound 2, both of them arranged in a free lattice. In both compounds, 3D supramolecular architecture is ultimately formed through the stacking of 2D layers. Since the length of the bpdc ligand is higher than that of the bdc ligand, the solvent‐accessible void volume is comparatively higher for compound 2. To corroborate all non‐bonded interactions, Hirshfeld analysis was carried out for synthesized compounds. DNA binding application was extensively investigated through docking study. Results indicated that the synthesized compounds have strong affinities towards DNA via DNA groove binding. Henceforth, the synthesized compounds 1 and 2 would open the door for their potential applications as particular protein binders and bioactive substances.
Exploring drivers and factors of benefit impact reports quality: Retracing a stakeholder theory approach
Authors: Esposito Paolo , Marrone Arcangelo , Pontrelli Vincenzo , Rella Angela
Published: October 2024

In the pursuit of global sustainability, firms play an increasingly pivotal role. In this scenario, Benefit Corporations aim to seamlessly integrate profit‐making endeavors with sustainable practices. This corporate model has spread around the world and in Italy; it was adopted through Law No. 208/2015 introducing Italian Benefit Corporations (BCs). Italian BCs must produce a Benefit Impact Report (BIR) alongside their financial statements, as a strategic communication tool for demonstrating the company's commitment to advancing common societal benefits to stakeholders. Leveraging stakeholder theory, this study adopts a mixed methodological approach that incorporates manual content analysis of BIRs from 132 Italian BCs, combined with a regression model exploring the impact of firm characteristics on the quality of BIRs. Findings highlight a positive relationship between firm size, financial leverage, and profitability on the quality of BIRs. This study is the first to explore the quality of BIRs and their determinants, providing academic and practical implications.
Does AI elevate corporate ESG performance? A supply chain perspective
Authors: Lin Boqiang , Zhu Yitong
Published: October 2024

As a pivotal catalyst for sustainable development, the evolution and integration of AI are propelling both companies and society toward a more efficient trajectory. Utilizing a multi‐period difference‐in‐difference (DID) model, the study assesses the impact of the 2019 China Artificial Intelligence Pilot (AIP) policy on corporate environmental, social, and governance (ESG). The study's findings are the following: (1) Optimizing corporate governance through artificial intelligence (AI), the AIP policy has significantly bolstered the ESG performance of companies in the pilot areas. (2) Mechanistic analysis demonstrates that the AIP policy elevates ESG by bolstering the efficiency of corporate supply chains. (3) Heterogeneity testing shows that the AIP policy exerts a more pronounced effect on non‐state‐owned companies, companies with high energy consumption, and those in the new energy sector. This manuscript furnishes empirical insights for evaluating the policy implications of AI development initiatives.
Omni‐channel customer segmentation: A personalized customer journey perspective
Authors: Van Nguyen Anh Thi , McClelland Robert , Thuan Nguyen Hoang
Published: October 2024

As switching behaviors become more prevalent in omni‐channel retailing, businesses face the challenge of crafting customer journeys that are not only seamless and integrated but also personalized. Personalization at the customer journey level requires a deep understanding of varied customer needs and behaviors. This research segments and profiles omni‐channel customers based on their perceptions, values, channel choices, and switching behaviors. We employed a mixed‐method approach, including 23 in‐depth interviews, four focus groups, and an online survey of 345 omni‐channel customers from electronic goods retailers. Our study identifies four distinct segments–digital switchers, webroomers, showroomers, and offline switchers–each requiring different experiences during their shopping journey. Theoretically, it confirms that customers with varying experience needs interact differently with channels, making the customer journey dynamic and individualistic in an omni‐channel context. Practically, our research suggests segment‐specific features for different channels, enabling managers and retailers to optimize and personalize omni‐channel shopping experiences.
The Second Methylation in Psilocybin Biosynthesis Is Enabled by a Hydrogen Bonding Network Extending into the Secondary Sphere Surrounding the Methyltransferase Active Site
Authors: Hudspeth Jesse , Rogge Kai , Wagner Tobias , Müll Maximilian , Hoffmeister Dirk , Rupp Bernhard , Werten Sebastiaan
Published: October 2024

The Psilocybe cubensis SAM‐dependent methyltransferase, PsiM, catalyzes the last step in the biosynthesis of psilocybin. Likely evolved from monomethylating RNA methyltransferases, PsiM acquired a key amino acid exchange in the secondary sphere of the active site, M247 N, which is responsible for its capacity to dimethylate. Two variants, PsiMN247M and PsiMN247A, were generated to further examine the role of Asn247 for mono‐ and dimethylation in PsiM. Herein, we present the kinetic profiles of both variants and crystal structures at resolutions between 0.9 and 1.0 Å. Each variant was crystallized as a ternary complex with the non‐methylated acceptor substrate, norbaeocystin and S‐adenosyl‐l‐homocysteine, and in a second complex with the cofactor analog, sinefungin, and the monomethylated substrate, baeocystin. Consistent with the inability of the variants to catalyze a second methyl transfer, these structures reveal catalytically non‐productive conformations and a high level of disorder of the methylamine group of baeocystin. Additionally, both variants exhibit destabilization in the β5‐β7 sheets and a conserved β‐turn of the core Rossmann fold, causing 20‐fold reduced substrate binding and 2‐fold lower catalytic efficiency even with norbaeocystin. Our structural and kinetic analyses of the variants suggest that Asn247 is essential to allow enough space in the active site for multiple methylations while also participating in a network of hydrogen bonds that stabilizes secondary structure elements in the immediate vicinity of the active site for optimal methylation of norbaeocystin.