bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Hand Gesture Command Using Leap Motion for Floorplanner Application
Authors: Marcellino Hendy
Published: January 2024

Architecture is part of the art of life and works best when it seems to give expression to the life that inhabits it. As technology has developed a lot, the field of architecture has also experienced many developments supported by technology such as making architectural designs. The development experienced in making architectural designs is that it is no longer required to draw design choices with side views on a lot of paper but instead use a simulation application for making architectural designs that are displayed through a monitor layer in 3D so that they can see more realistically. After many innovations emerged regarding simulation applications which generally still use hardware such as a mouse, then these innovations shifted to connecting the simulation application with the virtual world where hardware such as a mouse has been replaced by using gestures or limb movements such as parts of the hand or other parts of the body. While other fields like medic already use virtual tool interaction, architecture fields still just use mouse and keyboard. One of the virtual interaction devices used to be able to detect fingers and palms to interact with 3D simulation applications is Leap Motion. Leap Motion is starting to be widely used to carry out various ways of interacting with hands because it is more interactive and interesting to use even many people think that it can be used for hand rehabilitation or therapy too. However, even though many innovations have developed, there is still no innovation in the use of a hand gesture command system using Leap Motion for simulation applications to design architectural designs in 3D views. Based on these things, the authors designed and developed hand gesture commands using Leap Motion for Architectural Design App. The hand gesture command system used for the Floorplanner simulation application will be tested using a system usability scale by users with architectural, informatics, and unfamiliar backgrounds. Based on the tests carried out, it can be seen that the system is running properly even though it requires getting used to the device first and getting a score from the System Usability Scale of 59,167 out of scale from 0 to 100 which means it is still accepted by users or declared as "Marginally Acceptable" category.
Design of Automatic AB Mix Nutrition System for Wick System Hydroponics Based on IoT
Authors: Muhammad Tryora Inzaghi
Published: January 2024

Hydroponics is agricultural cultivation using water as a medium to replace soil. One of the simplest hydroponic systems is the wick system. The wick system is a passive system, where water is only stored in a container and there are no moving parts. The hydroponic growth of the wick system is very influential on the nutrient solution that is commonly used in hydroponic wick systems, namely AB mix nutrition. Providing AB Mix nutrient concentration of 1000-1300 ppm is the best concentration. The provision of nutrition is currently carried out by monitoring water conditions manually in the hydroponic system. This can cause monitoring not to be carried out so that it can have an impact on plant growth that is less than optimal. Therefore, the authors conducted research to design an automatic AB mix nutrition system for IoT-based hydroponic wick systems. This research makes it possible to provide AB mix nutrition automatically by utilizing a water level sensor, TDS (Total Dissolve Solid) sensor, water pump and using the MQTT data communication protocol. This study uses hardware testing to test all sensors such as TDS sensors, water level sensors and relays in terms of functionality. The results show that everything is working properly reading the changes that have occurred. After that, testing the entire system was carried out by making several scenarios to see the system's reaction to the scenarios that were made. The system can control the nutrient content of plants with the amount of nutrient content according to the needs of the pakcoy plant, which is 1000-1300 ppm. When the plants lack nutrients, the system will pump the nutrients into the hydroponic container to meet the nutritional needs of the plants.
Implementation of an Information System for Transaction Data Analysis Using the Holt-Winters Method
Authors: Murpratiwi Santi Ika , Rukmi Sari Hartati
Published: January 2024

Decision-making errors are fatal in company operations and often result in reduced profits. In making the right decisions, in-depth internal and external data analysis is required. One effort to increase decision-making accuracy is to apply a forecasting algorithm for existing transaction data. This research uses data mining and Forecasting for car repair companies. The information system being built is expected to be able to display a list of satisfied customer data, group transaction data based on the level of damage, and provide forecasts for the number of panels, number of units, and total revenue for the next period. From this data, it will be easier for management to determine the number of workers, additional tools, and stock of materials for the vehicle repair process. This information system was built by applying three algorithms, namely C4.5, K-Means, and Holt Winter Multivariate. The C4.5 algorithm will help group customer types, K-Means will help cluster vehicle damage levels, and Holt-Winters will be used for experience. The tests carried out included testing the accuracy of each algorithm, the black box system, and the system time so that the accuracy results were 100% for the C4.5 classification algorithm and 92.28% for the accuracy of K-Means which was tested with the purity measure. Meanwhile, the MAPE value for forecast testing was between 9 – 11% for each forecast.
User Requirement Analysis dalam penerapan metode User Centered Design sebagai pendukung kebutuhan UI/UX dalam aplikasi NTB Mall
Authors: Agitha Nadiyasari
Published: January 2024

User requirement analysis merupakan satu hal yang penting dilakukan dalam pembuatan sebuah user interface/user experience (UI/UX) menggunakan metode User Centered Design (UCD). Hal ini dikarenakan pada tahapan ini terdapat identifikasi dan dokumentasi kebutuhan pengguna. NTB mall adalah e-commerce pertama milik pemerintah daerah NTB dengan tujuan menjual produk unggulan daerah dari Usaha Mikro, Kecil Menengah (UMKM), Pedagang Kaki Lima (PKL) dan dibantu dengan pemantauan oleh Kelompok Sadar Wisata (Pokdarwis). Dalam pembuatan UI/UX NTBMall, diperlukan user requirement analysis yang kuat untuk mendapatkan penggunaan NTBMall yang sesuai dengan kebutuhan pengguna. User requirement analysis dibagi menjadi beberapa tahapan secara berurutan. Penggunaan user requirement analysis telah terbukti menghasilkan UI/UX yang menarik, dibuktikan dengan hasil pengujian SUS bernilai 72.82 yang mengartikan bahwa user telah puas dengan aplikasi NTBMall.
Pengembangan LKPD Berbasis Android dengan Pendekatan STEM untuk Meningkatkan Kemampuan Berpikir Kritis
Authors: Taqiyyah Syir' Anatut , Subali Bambang Subali , Linuwih Suharto , Ellianawati  , Siswanto  , Yusof Mohammad Mubarrak bin Mohd
Published: January 2024

Berpikir kritis adalah keterampilan dasar yang dibutuhkan di abad ke-21. Penelitian ini bertujuan untuk mengetahui kelayakan, efektivitas, pengaruh dan respon siswa LKPD berbasis Android dengan Pendekatan STEM untuk meningkatkan kemampuan berpikir kritis siswa. Jenis penelitian ini adalah R&D dengan tipe ADDIE. Sampel penelitian ini menggunakan teknik purposive sampling pada uji coba skala kecil dan skala besar di SMP Negeri 2 Demak. Aspek kemampuan berpikir kritis yang diteliti adalah aspek menjelaskan, analisis, evaluasi, menyimpulkan, interpretasi, sintesis, inferensi. Hasil penelitian menunjukkan bahwa, 1) LKPD berbasis Android dengan pendekatan STEM layak digunakan dalam pembelajaran IPA materi alat optik; 2) LKPD berbasis Android dengan pendekatan STEM mampu untuk meningkatkan kemampuan berpikir kritis dengan nilai N-Gain sebesar 70,82% dengan kategori tinggi; 3) LKPD berbasis Android dengan pendekatan STEM berpengaruh terhadap kemampuan berpikir kritis dengan thitung sebesar 24,484; 4) Respon siswa terhadap LKPD berbasis Android dengan pendekatan STEM diperoleh presentase 85% dengan kategori sangat setuju. Berdasarkan hasil penelitian ini, dapat disimpulkan bahwa LKPD berbasis Android dengan pendekatan STEM layak digunakan untuk meningkatkan kemampuan berpikir kritis.
Design Pitot Tube Cover with Artificial Intelligence (Arduino) Based Warning System on Piper Seneca V Aircraft
Authors: Putra Dimas Endrawan , Wibowo Untung Lestari Nur , Kuncoro Wisnu , Anam Muhamad Khoirul
Published: January 2024

The pitot tube is a component in the fuselage to measure the pressure generated by air movement or wind, while the placement of the pitot tube is usually on the wing. A trivial thing that can be fatal is that before flying, sometimes the pilot/flight instructor neglects to remove the pitot tank cover. This negligence resulted in the malfunctioning of the Air Speed Indicator (ASI), Vertical Speed Indicator and Altimeter. Appropriate technology in the form of a pitot tube cover with a warning using an ultrasonic sensor with the support of artificial intelligence technology using Arduino has been applied to the Piper Seneca V aircraft to prevent negligence in removing the pitot tube cover before flying. The Piper Seneca V has been chosen as the object of the application of technology because the Piper Seneca V type aircraft is of the low wing type so that the pitot tubes are not visible when not inspecting the underside of the aircraft's wings. During 30 days of testing with 12 hours of testing time each day and exposure to different temperatures and humidity each day, both battery life and component resistance can be ensured that they are still in optimal conditions. During testing in the simulation room, the tool worked well with a 1 meter object detection configuration. Using a 3.7 volt battery with a storage capacity of 1600 mAh can make the device last for 4 days with 2 hours of recharging time.
Antibacterial Activity of Pseudomonas Aeruginosa ISP1RL3 Against Multidrug Resistance Bacteria
Authors: Indraningrat Anak Agung Gede , Purnami Pande Putu Christine Putri , Aryastuti Anak Agung Sri Agung , Wijaya Made Dharmesti
Published: January 2024

Seaweed-associated bacteria have a pivotal role to synthesize arrays of secondary metabolites. This study described a bacterial isolate encoded as ISP1RL3 that was isolated from seaweed Eucheuma cottonii. Ethyl acetate extracts of ISP1RL3 was screened against non-multidrug bacteria (Staphylococcus aureus ATCC 25923, Streptococcus mutans FNCC 0405, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603) and multi-drug resistance bacteria (Methicilin-resistance S. aureus (MRSA), E. coli ESBL, K. pneumoniae ESBL, dan A.baumanii ESBL). Our result showed that ISP1RL3 displayed rod structure, Gram negative and identified as Pseudomonas aeruginosa. The crude extract displayed strong antibacterial activity against all bacterial test with the range zone of inhibition of 10 mm – 18 mm. The GC-MS analysis detected the presence of 13 antibacterial compounds with four dominant moleculer were o-Xylene, Ethylbenzene, p-Xylene and Benzene, 1,3-dimethyl. Overall, this finding highlights the potency of seaweed-associated bacteria to synthesize active compounds against multidrug resistance bacteria.
Attack Intensity of Coffee Berry Borer Hypothenemus Hampei Ferr at Different Altitudes in Simalungun Regency and Control Efforts Using Attractants
Authors: Girsang Rosmaria , Sipayung Mei Linda , Girsang Warlinson , Nurrachmani Meylida , Astuti Tri , Yudoyono Surya Bambang , Husin Ahmad
Published: January 2024

The research was carried out in people's coffee plantations at 4 locations at different altitudes in Simalungun Regency. The aim of the research was to determine the intensity of attacks by the coffee berry borer Hypothenemus hampei Ferr on land at different altitudes, and to determine the effectiveness of synthetic attractant traps to control it. The research method used a series design (randomized design series groups), which was carried out on coffee plantations at altitudes of 550, 850, 1,000 and 1,150 meters above sea level. At each plantation location, in an effort to control Hypothenemus hampei Ferr attacks, 3 (three) types of synthetic attractant traps were installed: Hypotan 500 SL, Koptan and Atrakop 500 L. The results of the research showed that the intensity of Hypothenemus hampei Ferr attacks tended to decrease in coffee plantation locations. higher above sea level and vice versa. The attractant types Hypotan 500 SL, Koptan and Atrakop 500 L showed no significant difference in effectiveness for trapping the coffee berry borer Hypothenemus hampei Ferr. However, these 3 types of attractants have not been able to reduce the intensity of attacks from puso, heavy and moderate categories to light attack categories.
Lineament Geomorphologic Analysis to Identify Fault in Mount Semeru, East Java
Authors: Malik Dian Pratiwi , Maryanto Sukir , Juwono Alamsyah Mohammad
Published: January 2024

This research analyzes the morphological lineaments on Mount Semeru, East Java. The morphological lineament is processed using satellite imagery as a digital elevation model (DEM), downloaded on the Badan Informasi Geospasial (BIG) page. The image was processed using Global Mapper software with azimuth angles of 00, 450, 900, 1800, and 3150 and produced a lineament map that had been overlaid from all azimuth angles and created a morphological lineament map with various groups of values from high to low. From the analysis that has been carried out, it was found that there are 103 lineaments, most of which are spread in the area west of the crater of Mount Semeru, with the dominant direction showing a west-southwest – east-northeast orientation.
Using Anthropometric Indices to Assess Change in the Nutritional Status of A Population: A Case Study from Samosir District, Indonesia
Authors: Sinaga Haripin Togap , Simbolon Ignasius Thomas Jorgi
Published: January 2024

Monitoring the growth of children under two years old needs to be carried out regularly to determine trends in nutritional status. Nutritional anthropometric data such as weight/age, height/age, and weight/height are important indicators in assessing nutritional status. The aim of this study was to analyze nutritional status based on the z-score of three anthropometric indices. This is a cross-sectional using secondary data taken web E-PPGBM from the year 2019-2022 in Samosir district. Around 17,349 data were taken from the web. The type of data collected was sex, age, birth weight and length, weight, and height of children aged 0-24 months. The z-score of weight/age, height/age, and weight/height was then analyzed by presenting the trend of each indicator. On average, there was an increase in z-score of weight/age and height/age in children aged 0-5 months and 6-11 months for girls and boys but not for weight/height. When entering aged 12-23 months z-score, girls z-score tend to decrease and boys ten to increase. However the range of z-score from -1.0 to 0.5. This study found that z-score of girls is higher than boys when they on ranged of age 0-12 months but when entering aged 13 months and upper, boys are more likely to have better nutrition than girls. Z-scores of three anthropometric indices in web  E-PPGBM is powerful for analyzing nutrition trend.
Pola Pelestarian Hutan Mangrove dan Dampak Bagi Masyarakat di Dusun Poton Bako Desa Jerowaru Kabupaten Lombok Timur
Authors: Jaelani Abd. Kadir , Syafruddin Syafruddin , Suud Suud
Published: January 2024

Penelitian ini memiliki tujuan guna: mengetahui Pola Pelestarian Hutan Mangrove dan Dampak Bagi Masyarakat di Dusun Poton Bako Desa Jerowaru Kabupaten Lombok Timur. Penelitian ini menerapkan pendekatan kualitatif dengan metode studi kasus. Teknik pengumpulan data yang diterapkan pada penelitian ini yakni, wawancara, observasi serta dokumentasi. Teknik analisis data pada penelitian ini yakni reduksi data, penyajian data serta menarik kesimpulan. Hasil penelitian menerangkan bahwasanya (1) Pola Pelestarian Hutan Mangrove di Dusun Poton Desa Jerowarau yaitu Pola Pengembangan Ekowisata Mangrove (pengelola bersama dengan masyarakat membersihkan hutan mangrove dari sampah yang menumpuk di kawasan hutan mangrove untuk dikembangkan menjadi wisata mangrove), Pola Rehabilitasi Ekosistem Mangrove (pengelola melakukan pembuatan areal pembibitan skala kecil untuk membuat stok bibit mangrove untuk di tanam kembali), Pola Konservasi Ekosistem Mangrove (pengelola membentuk anggota Pokmaswas dengan tujuan sebagai pengawas untuk mencegah terjadinya penebangan pohon mangrove secara liar). (2) Dampak Pelestarian Hutan Mangrove Bagi Masyarakat di Dusun Poton Bako yaitu Dampak Positif (menciptakan lapangan pekerjaan baru untuk masyarakat dusun poton bako; meningkatkan penghasilan prekonomian masyarakat dengan dikeloanya hutan mangrove menjadi tempat wisata dan tempat penjualan produk umkm seperti kopi mangrove, minatur sampan/perahu dan baju khas wisata bale mangrove; hasil tangkapan nelayan dusun poton bako meningkat dan apabila cuaca tidak mendukung untuk melaut masyarakat nelayan bisa untuk mencari udang, ikan dan kepiting di kawasan hutan mangrove; mayarakat mendapatkan edukasi dan kesadaran masyarakat menjadi meningkat untuk menjaga kawasan hutan mangrove; kawasan pesisir pantai dusun poton bako terhindar dari abrasi dan mencegah instrusi air laut ke darat.Kata Kunci: Pola Pelestarian; Dampak Pengelolaan; Hutan Mangrove
Prevalence and risk factors for prolonged mechanical ventilation in patients with congenital heart diseases undergoing cardiac surgery at a tertiary care center.
Authors: Ammad Hussain  , Rajab Ali Khokhar  , Rehman Mujeeb ur , Zubair Ahmed  , Veena Kumari  , Saad Bader  , Abdul Sattar Shaikh
Published: January 2024

Objective: To determine the prevalence and risk factors for prolonged mechanical ventilation (PMV) in patients with CHDs undergoing cardiac surgery at a tertiary care center of Karachi, Pakistan. Study Design: Cross-sectional study. Setting: Paediatric Cardiac Intensive Care Unit (PCICU) at National Institute of Cardiovascular Diseases, Karachi, Pakistan. Period: July 2022 to June 2023. Material & Methods: We analyzed patients who underwent open or closed heart surgery for CHDs. PMV was defined as duration of mechanical ventilation > 72 hours from the time of arrival to PCICU until extubation after cardiac surgery. Peri-operative factors were noted and their association with PMV was documented. Results: In a total of 184 patients who underwent surgeries for CHD, 105 (57.1%) were male while the overall mean age was 7.23±6.49 years. Post-surgery, PMV was documented in 17 (9.2%) patients. PMV was significantly associated with age (p=0.001), weight (p<0.001), cyanosis (p=0.005), TAPSE (p=0.011), and CPB time (p=0.003). Post-surgery, PMV was linked with metabolic acidosis (p=0.003), lactate (p=0.001), AVDO2 (p<0.001), inotropic score (p=0.002), low cardiac output (p=0.005), LV dysfunction (p<0.001), acute kidney injury (p=0.002), sepsis (p<0.001), pneumonia (p=0.004), mortality (p=0.045), and PCICU stay (p<0.001). Conclusion: PMV was documented in 9.2% patients who underwent CHD repair. Age, weight, cyanosis, TAPSE, CPB time, metabolic acidosis, lactate, AVDO2, inotropic score, low cardiac output, LV dysfunction, acute kidney injury, sepsis, and pneumonia were noted to be significant risk factors for PMV.
Pulmonary hypertension within individuals suffering from chronic obstructive pulmonary disease.
Authors: Zeeshan Ashraf  , Muhammad Ashraf
Published: January 2024

Objective: To establish the frequency in regards to pulmonary hypertension within individuals suffering from chronic obstructive pulmonary disease. Study Design: Cross-sectional study. Setting: Pulmonology Division of Jinnah Hospital Lahore. Period: January, 2023 to April, 2023. Material & Methods: A total of 200 patients of both male and female patients with age from 40 to 70 years having chronic obstructive pulmonary disease were included by nonprobability consecutive sampling. Patients with history of other respiratory disease like interstitial lung disease, bronchiectasis, allergic broncho-pulmonary aspergillosis (ABPA), sarcoidosis, occupational lung diseases, asthma, ischemic heart disease, pulmonary hypertension, collagen vascular disease were factored out of the study. Cardiac echocardiography was performed in all the patients and pulmonary hypertension as assessed. Results: In this study, 87 (43.5%) were between 40-55 years of age while 113 (56.5%) were within the ages of 56-70, and thus the mean age was 57.28±8.44 years. 131 (65.5%) patients were male and 69 (34.5%) were females. 49 (24.5%), 103 (51.5%) and 48 (24%) patients had mild, moderate and severe COPD respectively. Pulmonary hypertension was found in 105 (52.5%) patients. Pulmonary hypertension is more prevalent in severe cases of COPD than mild and moderate patients with p-value = 0.0001. Conclusion: Patients with chronic obstructive lung disease have a high prevalence of pulmonary hypertension. This is shown to be more common within patients suffering from severe cases of COPD.
Correlation of Height with head circumference and length in Female population of Upper Punjab.
Authors: Fozia Bibi  , Mashooque Ali  , Muzaffar Munir  , Shaiqa Ramzan  , Muhammad Saad Abdullah  , Salman Khan
Published: January 2024

Objective: To determine the relationship between head length, head circumference, and height in females of upper Punjab because cranial measurements are a more accurate and dependable way of estimating stature. Study Design: Descriptive Cross-sectional. Setting: Upper Punjab CMH Kharian Medical College. Period: May 2022 to May 2023. Material & Methods: This descriptive cross-sectional research involved n=382 females in upper Punjab who were between the ages of 20 and 25. A distributing calliper and a non-elastic tape were used to measure the head's length and circumference, respectively. A common height measuring tool was used to measure height. The female's height and head circumference were both measured in centimetres. The collected data were analysed to determine the relationship between head circumference and height as well as head length and height. For the statistical information, Pearson's correlation coefficient was used, and data were analysed. Results: Head length and height were shown to be significantly positively correlated (r=0.518, p<0.001). Height and head circumference were shown to have a substantial positive connection (r=0.344). Conclusion: In the current research, it was found that in females from upper Punjab, there had been a substantial positive association between height and head length, showing that head length is a trustworthy predictor in estimating height. Additionally, there was a significant positive relationship between females' head circumference and height.
A PSICOLOGIA DA AUTORREALIZAÇÃO NA VIDA DE SANTA DULCE DOS POBRES: UM ESTUDO SOBRE A MOTIVAÇÃO DE PESSOAS QUE ESCOLHEM PERSISTIR NA BUSCA DE OBJETIVOS GRANDES E ÁRDUOS
Authors:   , Batista Lilianny dos Santos
Published: January 2024

O presente estudo buscou identificar na vida de Santa Dulce dos Pobres se há aspectos da
motivação humana para a autorrealização a partir das abordagens da Psicologia Humanista e
da Psicologia Positiva. Para isto foi realizada uma revisão narrativa de literatura onde foram
apresentadas teorias presentes na Psicologia que discutem sobre a motivação para a
autorrealização, partindo das contribuições da Psicologia Humanista de Abraham Maslow e da
Psicologia Positiva. A partir da pesquisa documental foi apresentado quem foi Santa Dulce dos
Pobres, pontuando fatores que levaram a ser uma personalidade baiana conhecida por suas
ações sociais. Por fim, o estudo analisou experiências na vida de Santa Dulce dos Pobres no
que se refere à tendência de motivação para o crescimento ou autorrealização. Observou-se, na
trajetória da religiosa, aspectos que caracterizam um indivíduo motivado pela autorrealização:
a busca por um alto padrão em seus objetivos, motivação por crescimento e reduzida motivação
por deficiência e resistência em meio às dificuldades.
Desembrulhar ficções
Authors: Pimenta Susana , Prodanov Sofia Schemes , Postal Ricardo , Ribeiro Orquídea Moreira , Baptista Maria Manuel , Éboli Luciana Morteo , Minuzzi Luara , Ribeiro Laura Severo , Saraiva Juracy Assmann , Mineiro Imara Bemfica , Barbosa Jr Francisco Welligton , Moreira Fernando Alberto Torres , Mugge Ernani , Cabral Éderson de Oliveira , Paz Demétrio Alves , Conte Daniel , Prodanov Cleber Cristiano , Schemes Claudia
Published: January 2024

[...] esta obra reúne materialidades resultantes de pesquisas desenvolvidas por pesquisadores de universidades brasileiras e portuguesas. São investigadores partícipes dos programas de pós-graduação em Ciências da Cultura, da Universidade de Trás-os-Montes e Alto Douro, e em Processos e Manifestações Culturais, da Universidade Feevale, bem como colaboradores das pesquisas realizadas nesses programas ou, ainda, que estão vinculados aos grupos de pesquisas registrados nos diretórios de agências de fomento do Brasil e da Europa. Serviram como objetos das reflexões teórico-críticas aqui reunidas, narrativas literárias e ensaísticas escritas em língua portuguesa que se apresentam marcadas pela história política, social e cultural dos territórios que lhes servem de cenário, emergindo de condições de produção específicas em que as máculas do arranjo simbólico do fenômeno humano e dos aparelhos ideológicos (os quais comportam e colocam em marcha a repetição dos arquétipos do domínio colonial) são evidentes e traumáticas. Isso ocorre porque a materialidade ficcional dá forma concreta a anseios, dilemas, angústias, devaneios e impasses por meio de representações gestadas desde as estruturas do imaginário social.
Microwave-Assisted Reactivity of a Fischer Alkynyl Carbene Complex with Benzylidene Anilines
Authors: Delgado Reyes José Francisco , Feliciano Alberto , Vazquez Miguel A. , Velazco-Cabral Iván Velazco-Cabral , Vazquez Juan Luis Vazquez , Benitez-Puebla Luis Javier Benitez-Puebla , Mastachi Salvador , Lagunas-Rivera Selene , García-Revilla Marco A.
Published: January 2024

The reaction between the Fischer carbene complex (CO)5Cr=C(OEt)CºCPh and various benzylidene anilines RCH=NR1 was promoted by microwave irradiation, generating stable cross-conjugated metallahexatrienes in 45-70 % yield. Compared to conventional heating, the present conditions provided shorter reaction times with moderate yields. The geometrical configuration and the most stable conformation for each of the Fischer carbene complexes and their oxidation products were established by NMR and DFT analysis. The reaction mechanism was explored by DFT calculations of the potential energy surface, suggesting a 1,4-addition/ring closure/electrocyclic opening cascade process.
 
Resumen. Se reporta la reactividad entre el carbeno de Fischer (CO)5Cr=C(OEt)CºCPh y las bencilidén anilinas, RCH=NR1, empleando irradiación de microondas. Los resultados indican que el calentamiento por microondas generó metalohexatrienos cruzados estables en rendimientos de 45-70 %, mostrando además, que los nuevos complejos se obtienen en tiempos de reacción más cortos y rendimientos moderados en comparación con las condiciones de calentamiento convencional. La configuración geométrica y la conformación más estable para los complejos carbénicos de Fischer y de sus derivados oxidados fueron establecidos por medio de RMN y DFT. La exploración de la superficie de energía potencial por cálculos DFT mostró que el proceso consistió en una reacción en cascada incluyendo una secuencia de adición-1,4, cierre de anillo y apertura electrocíclica.
DFT and Molecular Docking Studies of Melatonin and Some Analogues Interaction with Xanthine Oxidase as a Possible Antiradical Mechanism
Authors: Manzanilla Brenda , Martinez-Alfaro Minerva , Robles Juvencio
Published: January 2024

Melatonin (Mel) and some of its active metabolites such as N1-acetyl-5-methoxykynuramine (AMK), N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), 6-hydroxymelatonin (6OHM), and the analogues Ir and It recently designed by Galano's group, have been studied within density functional theory (DFT). The purpose is to evaluate some plausible mechanisms of action of melatonin's metabolites and analogues with the free radicals (FR): OH ̇, NO ̇2, HOO ̇, and CH3O͘ . We calculated global chemical reactivity descriptors from conceptual DFT to evaluate their antiradical properties. We used water and pentyl ethanoate as solvents to simulate the physiological conditions, modeled via the continuum solvation model based on density (SMD). We assess the following plausible mechanisms: single electrons transfer (SET), hydrogen atom transfer (HAT) and xanthine oxidase (XO) inhibition. We performed our calculations at the M06-2X/6-31+G* level of theory. The results indicate that Mel, AMK, AFMK, 6OHM, It, and Ir are good antiradicals towards the FRs: NO ̇2 and CH3O , while It and Ir could be suitable XO inhibitors.
Keywords: Antiradical properties; Density Functional Theory; melatonin; xanthine oxidase; molecular docking.
 
Resumen. La melatonina (Mel) y algunos de sus metabolitos activos como N1-acetil-5-metoxiquinuramina (AMK), N1-acetil-N2-formil-5-metoxiquinuramina (AFMK), 6-hidroximelatonina (6OHM) y los análogos Ir e It, diseñados recientemente por el grupo de Galano, han sido estudiados con la teoría de funcionales de la densidad (DFT). El propósito es evaluar algunos mecanismos de acción plausibles de los metabolitos y análogos de la melatonina con los radicales libres (FR):OH ̇, NO ̇2, HOO ̇ y CH3O ̇. Calculamos los descriptores de reactividad química global a partir de DFT conceptual para evaluar sus propiedades antirradicales. Usamos agua y etanoato de pentilo como solventes para simular las condiciones fisiológicas, modeladas a través del modelo continuo de solvatación basado en la densidad (SMD). Evaluamos los siguientes mecanismos plausibles: transferencia de electrones individuales (SET), transferencia de átomos de hidrógeno (HAT) e inhibición de la xantina oxidasa (XO). Realizamos nuestros cálculos al nivel de teoría M06-2X/6-31+G*. Los resultados indican que Mel, AMK, AFMK, 6OHM, It e Ir son buenos antirradicales frente a los FRs:  NO ̇2 y CH3O ̇, mientras que It e Ir podrían ser inhibidores adecuados de XO.
In Vitro and In Silico Studies of Bis-furyl-pyrrolo[3,4-b]pyridin-5-ones on Dengue Virus
Authors: Morales-Salazar Ivette , Garduño-Albino Carlos E. , Montes-Enríquez Flora P. , Gutiérrez-Carrillo Atilano , Rojas-Aguirre Yareli , Estrada-Toledo Nancy Viridiana , Sandoval-Basilio Jorge , Alcaraz-Estrada Sofía Lizeth , Díaz-Cervantes Erik , González-Zamora Eduardo , Islas-Jácome Alejandro
Published: January 2024

A series of six bis-furyl-pyrrolo[3,4-b]pyridin-5-ones synthesized via an Ugi-Zhu reaction coupled to a cascade process [aza Diels-Alder cycloaddition/N-acylation/aromatization] were evaluated in vitro against Dengue virus serotype 4 infection, and the Dengue virus replicon system encoding a Renilla luciferase gen reporter. Also, in silico studies on the non-structural protein 3 (NS3), a flavivirus protease comprising an attractive target for development of therapeutic antivirals bound to non-structural protein 2B (NS3-NS2B) were performed. The in vitro results showed that compounds 1a and 1b reduced the expression of Renilla luciferase in 44.2 and 31.6%, respectively. Additionally, the same compounds decreased viral load, thus revealing their potential activity against Dengue virus serotype 4. From in silico simulations, it was developed a NS3-NS2B model, which was used as a target for the studied molecules. Computational results agree with experimental data, showing that 1a is the best ligand. Finally, a pharmacophoric model was computed for NS3-NS2B, which shows that the ligands need two hydrophobic and one hydrophilic fragment. Such results suggest that two out of the six synthesized bis-furyl-pyrrolo[3,4-b]pyridin-5-ones derivatives presents potential antiviral activity against Dengue virus in vitro.
 
Resumen. Una serie de seis bis-furil-pirrolo[3,4-b]piridin-5-onas sintetizadas vía una reacción Ugi-Zhu acoplada a un proceso en cascada [cicloadición aza Diels-Alder/N-acilación/aromatización] fueron evaluadas in vitro contra infección por el serotipo 4 del virus del dengue y el sistema de replicón del virus del Dengue que codifica un gen reportero de la luciferasa de la Renilla. Además, se realizaron estudios in silico sobre la proteína no estructural 3 (NS3), una proteasa de flavivirus que comprende un blanco atractivo para el desarrollo de antivirales terapéuticos unidos a la proteína no estructural 2B (NS3-NS2B). Los estudios in vitro revelaron que los compuestos 1a y 1b reducen la expresión de Renilla luciferasa en un 44.2 y 31.6%, respectivamente. Adicionalmente, estos compuestos redujeron la carga viral, revelando así su actividad potencial contra el virus del Dengue serotipo 4. Derivado de las simulaciones in silico, se obtuvo un modelo homólogo para NS3-NS2B, el cual fue considerado como blanco de las moléculas estudiadas. Los resultados computacionales correlacionan con los experimentales, mostrando que 1a es el mejor ligando. Finalmente, se generó un modelo farmacofórico para NS3-NS2B, el cual muestra que los ligandos necesitan dos fragmentos hidrofóbicos y uno hidrofílico. Estos resultados demuestran que dos de los seis compuestos que se estudiaron presentan actividad antiviral in vitro.
Laplace transform method for logistic growth in a population and predator models with fractional order
Authors:   Ibn Khaldoon College, Program of Information Technology, Khartoum, Sudan., Ahmed Abubker ,   AlMughtaribeen University, College of Engineering, Department of General Sciences, Sudan.,   University of Science & Technology, College of Engineering, Sudan.
Published: January 2024

In this paper, we develop a new application of the Laplace transform method (LTM) using the series expansion of the dependent variable for solving fractional logistic growth models in a population as well as fractional prey-predator models. The fractional derivatives are described in the Caputo sense. To illustrate the reliability of the method some examples are provided. The results reveal that the technique introduced here is very effective and convenient for solving fractional-order nonlinear differential equations.
Stability in respect of chromatic completion of graphs
Authors:   School of Mathematical Sciences, University of Witwatersrand, Johannesburg, South Africa., Mphako-Banda Eunice Gogo , Kok Johan ,   Independent Mathematics Researcher, City of Tshwane, South Africa & Visiting Faculty at CHRIST (Deemed to be a University), Bangalore, India.
Published: January 2024

In an improper coloring, an edge \(uv\) for which, \(c(u)=c(v)\) is called a bad edge. The notion of the chromatic completion number of a graph \(G\) denoted by \(\zeta(G),\) is the maximum number of edges over all chromatic colorings that can be added to \(G\) without adding a bad edge. We introduce the stability of a graph in respect of chromatic completion. We prove that the set of chromatic completion edges denoted by \(E_\chi(G),\) which corresponds to \(\zeta(G)\) is unique if and only if \(G\) is stable in respect of chromatic completion. After that, chromatic completion and stability regarding Johan coloring are discussed. The difficulty of studying chromatic completion of graph operations is shown by presenting results for two elementary graph operations.
Evaluating Behavioural Modelling Predictions in the Blue Shark (Prionace glauca) Enables Greater Insight on Habitat Use from Location only Argos Data
Authors: Elliott Riley , Zhang Jingjing , Dennis Todd , Montgomery John , Radford Craig
Published: January 2024

The relationship between habitat and behaviour provides important information for species management. For large, free roaming, marine animals satellite tags provide high resolution information on movement, but such datasets are restricted due to cost. Extracting additional biologically important information from these data would increase utilisation and value. Several modelling approaches have been developed to identify behavioural states in tracking data. The objective of this study was to evaluate a behavioural state prediction model for blue shark (Prionace glauca) ARGOS surface location-only data. The novel nature of the six SPLASH satellite tags used enabled behavioural events to be identified in blue shark dive data and accurately mapped spatio-temporally along respective surface location-only tracks. Behavioural states modelled along the six surface location-only tracks were then tested against observed behavioural events to evaluate the model's accuracy. Results showed that the Behavioural Change Point Analysis (BCPA) model augmented with K means clustering analysis performed well for predicting foraging behaviour (correct 86% of the time). Prediction accuracy was lower for searching (52%) and travelling (63%) behaviour, likely related to the numerical dominance of foraging events in dive data. The model's validation for predicting foraging behaviour justified its application to nine additional surface location-only (SPOT tag) tracks, substantially increasing the utilisation of expensive and rare data. Results enabled the critical behavioural state of foraging, to be mapped throughout the entire home range of blue sharks, allowing drivers of critical habitat to be investigated. This validation strengthens the use of such modelling to interpret historic and future datasets, for blue sharks but also other species, contributing to conservational management.
Intrusion detection system in a hardware in the loop scenario
Authors: Berenice Arzate-Rueda  , Enrique Reyes-Archundia  , Juan C. Olivares-Rojas  , Jose A. Gutiérrez-Gnecchi  , Maria del C. García-Ramírez  , Marco V. Chávez-Báez  , Javier A. Rodríguez-Herrejón
Published: January 2024

Detecting perturbation in electrical signals is crucial to assure power quality (PQ) and protect equipment connected to an electrical network. Some of the information generated by disturbances analysis can be communicated using Internet of Things (IoT) protocols, but it is vital to verify the integrity of the data. As a result of the lack of security presented by IoT devices, the proposal of this work is based on the implementation of an algorithm based on IDS that allows identifying attacks or failures in the security of an IoT-based PQ disturbance detection system implemented in a BeagleBone Black Wireless. The Sparta and Sqlmap programs were used as tools to perform tests and detect security flaws in the BeagleBone, verifying essential operations of the IDS.
A cardinal change in heat treatment of metallic alloys
Authors: Yuri Ustinovshikov
Published: January 2024

This article shows that the current heat treatment, based on the misconceptions of the last century, should be. Here we present to the reader the results of experiments obtained on two binary alloys Ni75Mo25 and Ni75Co25, as well as on one ternary alloy Ni50Mo25Co25. These data can be considered similar to the data we presented earlier obtained on alloys of 17 binary systems and 7 ternary alloys. The article gives the experimental evidence that all processes occurring in the metallic alloys during heat treatment owe their origin to interatomic chemical bonds (ionic and covalent) that exist at all temperatures of the condensed state. This means that at each heating temperature of the alloy, its own microstructure forms, which differs from microstructures at other temperatures in the composition or dispersity of the precipitated particles. Here, alloy quenching "from the region of solid solutions" turns out to be an unnecessary operation. The article proposes to exclude it from the technological process, limiting itself only to tempering. This will bring large savings to all machine-building plants around the world.
Navigating growth: Unraveling the interplay between marketing strategies and social media in the economic development of nations
Authors: Ambili K
Published: January 2024

This research article delves into the dynamic relationship between marketing strategies and social media in shaping the economic development of countries. In an era where globalization and digitalization are driving transformative changes, understanding the pivotal role of marketing and social media becomes crucial for policymakers, businesses, and academics alike. The study employs a multidisciplinary approach, drawing on insights from economics, marketing, and communication studies to analyze the impact of marketing practices and social media engagement on economic growth. The research explores how effective marketing strategies, including product differentiation, brand management, and targeted advertising, can stimulate economic activities and enhance the competitiveness of nations in the global market. Furthermore, the article investigates the amplifying effects of social media platforms on the dissemination of marketing messages, consumer behavior, and market trends. It examines how the interconnected nature of social media networks facilitates the rapid spread of information, influencing consumer preferences and fostering entrepreneurship. Moreover, the study investigates the potential challenges and ethical considerations associated with the intersection of marketing and social media in economic development. It scrutinizes issues such as privacy concerns, misinformation, and the digital divide, providing insights into mitigating risks and promoting responsible marketing practices.
Seasonal variation of antibiotic resistance of Salmonella spp. and Escherichia coli strains isolated from well water of Moundou city, Chad (Central Africa)
Authors: Jaïrus Dionkas  , Naré Bongo Ngandolo  , Serge Hubert Zébazé Togouet
Published: January 2024

Antibiotic resistance has become a global concern, mainly in developing countries, due to the socio-economic and health issues. This work aims to test the antibiotic susceptibility of germs isolated from well water consumed in the city of Moundou. This study was carried out during the period from May 2019 to July 2020 covering the two seasons of Chad. The results showed that in the rainy season resistance and sensitivity tests presented an increase in resistance to ceftriaxone, 100% for Escherichia coli and 87.5% for Salmonella spp.; ampicillin, 77.7% for Escherichia coli and 75% for Salmonella spp.; amoxicillin + clavulanic acid, 55.5% for Escherichia coli and 50% for Salmonella spp. During the dry season, very high bacterial resistance was noted to ampicillin (100%), amoxicillin + clavulanic acid (66.6%) and amoxicillin +sulbactam (33.3%) for Escherichia coli. This resistance was 88.8% to ceftriaxone, 50% to amoxicillin and ampicillin, 38.8% to amoxicillin + clavulanic acid, and 33.3% to amoxicillin + Sulbactam for Salmonella spp. However, no resistance to gentamicin was noted during both dry and rainy seasons. This study revealed strains of Escherichia coli and Salmonella spp. in the wells water of the city of Moundou and the use of these waters by the populations without prior treatment can lead to health risks. Poor sanitation and hygiene as well as the careless and abusive use of antibiotics in livestock have been felt even in the underground aquatic environment favoring the emergence of resistant strains.
Factors associated with adolescent pregnancy: A literature review
Authors: Aliza Tri Puspitasari  , Nabella Indra Putry Sukmawaty
Published: January 2024

The number of high-risk pregnant women always shows a fairly large number every year Adolescence pregnancy is in the spotlight in various countries because of the harmful effects. The purpose of this study was to determine the factors associated with adolescence pregnancy. This research uses the literature review method. The data were sourced from national scientific journal articles obtained through Google Scholar, and Pubmed using the keywords “Adolescent pregnancy", “ Knowledge’’, ‘’Parents”, “Education’’ and " Economic condition". This study shows that the factors associated with adolescent pregnancy are the role of parents, latest education, sex knowledge and economic conditions.
Review of technological advancement in food supply chain management: Comparison between USA and Africa
Authors: Osato Itohan Oriekhoe  , Bankole Ibrahim Ashiwaju  , Kelechi Chidiebere Ihemereze  , Uneku Ikwue  , Chioma Ann Udeh
Published: January 2024

This review paper examines the technological advancements in food supply chain management, drawing a comparative analysis between the United States (USA) and Africa. The global food supply chain plays a critical role in ensuring the efficient and effective distribution of food products from producers to consumers. In recent years, technological innovations have revolutionized various aspects of the food supply chain, impacting areas such as production, distribution, traceability, and sustainability. The paper begins by providing an overview of the key technological trends in food supply chain management, encompassing the adoption of Internet of Things (IoT) devices, blockchain technology, artificial intelligence (AI), and data analytics. These innovations have the potential to enhance transparency, reduce waste, improve traceability, and optimize overall supply chain efficiency. A comparative analysis is then conducted, focusing on the disparities and similarities in the adoption and implementation of these technologies between the USA and Africa. The USA, as a technologically advanced region, has witnessed extensive integration of cutting-edge technologies in its food supply chain. This includes the utilization of IoT sensors for real-time monitoring, blockchain for transparent and secure transactions, and AI for predictive analytics and demand forecasting. In contrast, Africa, characterized by a diverse range of economies and infrastructural challenges, faces unique opportunities and obstacles in embracing advanced technologies in its food supply chain. The review explores initiatives and case studies that highlight the successful integration of technology in various African countries, shedding light on the potential for leapfrogging certain stages of traditional supply chain development. The discussion encompasses the role of government policies, private sector involvement, and international collaborations in shaping the technological landscape of food supply chain management in both regions. Furthermore, attention is given to the social and economic implications of technological advancements, emphasizing the need for inclusive approaches that address the specific needs of diverse communities. This review provides valuable insights into the current state of technological advancements in food supply chain management, offering a comparative perspective between the USA and Africa. By understanding the challenges and opportunities faced by each region, stakeholders can develop targeted strategies to enhance the resilience, sustainability, and inclusivity of global food supply chains in the face of evolving technological landscapes.
A study on anti-diabetic prescription along with patients in Bangladeshi perspective
Authors: Md Rajib, Majedul Hoque  , Rabia Akter Bijly  , Md. Ferdous Hossain  , Iftear Kazim Rafi
Published: January 2024

Diabetes is the main cause for inability and premature death in Bangladesh. As a part of treatment, Patients may have lifestyle changes, medications, surgery or other medical procedures. The aim of current research is to seek out therapy pattern for diabetes treatment in Bangladesh. A cross sectional study was performed in the government and private hospitals situated in Dhaka. 144 prescriptions of diabetic patients are collected from BIRDEM and BIHS Diabetic Center has 77 Male patient (53.47%) and female patient number 67 (46.53%). Most prescription drugs have captured Sitagliptin 34.02%, Linagliptin 20.83%, Metformin Hydrochloride 20.13%, Gliclazide 25%. Other results of this studies are described throughout the study and discussion. This research result focused on prescription pattern, lifestyle and awareness of patients. Those who are affected and plagued by the diabetes disease should be more responsive to this aspect, because little negligence is often the main reason for their life threat.