bluuebunny/crossref_metadata_2025 huggingface dataset:
Phytoplankton change along the length of the Ural River under conditions of eutrophication
Authors: Goncharov A. V. , Sakharova E. G. , Frolova N. L. , Polyanin V. O.
Published: September 2024

For the first time, the change of phytoplankton along the length of the Ural River from Verkhneuralsk to Orenburg (on a site of more than 1000 km) was studied. A powerful eutrophying effect of Magnitogorsk on the river for more than 150 km has been revealed. It manifests itself in the fact that the phytoplankton biomass in this area increases greatly, averaging about 15 mg/ l (with the dominance of cyanobacteria Microcystis aeruginosa), and the species diversity index (Shannon index), on the contrary, reaches extremely low values of 0.25. This indicates a significant oppression of the plankton community and deterioration of water quality. In the Ural River above this site (from Verkhneuralsk to Magnitogorsk reservoir), as well as below it (from Orsk to Orenburg), phytoplankton indicators correspond to the usual values: biomass is 1.6–1.7 mg/l, Shannon index is 3.3–3.5 (on average for each site). This suggests that the conditions for the existence of plankton in the upper and lower areas are favorable. At the same time, the sites differ in the composition of algae: the first is dominated by diatoms, the second is predominantly green. Perhaps this is due to geographical factors: in the north, the Urals flows in the forest-steppe zone, and in the south it passes into the steppe.
Ambivalence of planktonic invaders and transformation of communities
Authors: Telesh I. V. , Naumenko E. N.
Published: September 2024

The ambivalence of planktonic invaders has been studied using the example of ecosystem effects of the invasive cladoceran Cercopagis pengoi (Ostroumov, 1891) in the Vistula Lagoon of the Baltic Sea. The influence of the invader on the taxonomic structure and productivity of plankton is studied. It is discovered that, in the long term, the predation pressure of C. pengoi on zooplankton has decreased; the abundance, biomass, and production of the dominant species Rotifera, Cladocera, and Copepoda also declined. The negative impact of C. pengoi on the planktonic community is reflected in a reduction in the food supply of juvenile Baltic herring and other planktivorous fish. The wide ecological niche of Cercopagis contributes to the expansion of its range, which can lead to a reduction in populations of phytophagous crustaceans, increased water blooms, and the further deterioration of the food supply of fish.
To the issue of mythological reality of modern german-language media text
Authors: Slesarev Alexey G.
Published: September 2024

The actualization of the consciousness myth is realized through a mythological text. In modern society, media text can represent mythological text. The main criterion for identifying such media text as mythological reality is the repeated uncritical and categorical canonicity of subject-object relations in a special unformalized time and space as the only true one. In the practice of German-language media this can be found in an axiomatic and unreasoned exaltation of German cultural achievements, such as gender balance in linguistic practice, the absolutism of the ideals of Western democracies, representation of the German nation as a “victim of war,” etc. The individual – as well as the author of the media text – always unconsciously strives to bring his actualizations in line with the collective ones, and the collective, in turn, accepting and updating the individual as the general (reduplication), has a reverse influence on the individual, due to which the world perception of the individual and the collective tends to identity. The mythical in the German media text is found both in its structure and in the features of media speech.
The rights and duties of the individual: in search of civil consent. Review of the International Conference “The Russian statehood and the challenges of the XXI century”, dedicated to the 30th anniversary of the Constitution of the Russian Federation and the 40th anniversary of the Department of State and Legal Disciplines of the Academy of Management of the Ministry of Internal Affairs of the Russian Federation
Authors: Pozharsky Dmitry V. , Krotkova Natalya V.
Published: September 2024

The article provides an overview of the International Conference “The Russian statehood and challenges of the XXI century”, dedicated to the 30th anniversary of the Constitution of the Russian Federation and the 40th anniversary of the Department of State and Legal Disciplines of the Academy of Management of the Ministry of Internal Affairs of Russia.
The forum was held in a mixed (face-to-face and online) format on three discussion platforms (a plenary session, a round table and a rostrum of a young scientist).
Mechanism study of serum extracellular nano-vesicles miR-412-3p targeting regulation of TEAD1 in promoting malignant biological behavior of sub-centimeter lung nodules
Authors: Deng Yuxia , Patel Nishant , Ding Shuang , Zhang Haijun
Published: September 2024

OBJECTIVE:

To investigate the impact and potential mechanisms of serum extracellular nano-vesicles (sEVs) miR-412-3p released from sub-centimeter lung nodules with a diameter of [Formula: see text] 10 mm on the malignant biological function of micro-nodular lung cancer (mnLC).

METHODS:

A total of 87 participants were included and divided into a mnLC group ([Formula: see text] 30), a benign lung nodule (BLN) group ([Formula: see text] 27), and a healthy people control group ([Formula: see text] 30). Transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and Western blot (WB) were used to measure the morphological characteristics and surface markers of sEVs. In vitro analysis, real-time quantitative polymerase chain reaction (RT-qPCR), CCK-8 cell proliferation assay, clone formation assay, Transwell, stem cell sphere-forming assay, and WB assay were conducted to verify the effect of miR-412-3p/TEAD1 signaling axis on the biological function of lung cancer cells through, respectively. Further validation was conducted using the serum sEVs of the participants.

RESULTS:

The expression level of sEVs-miR-412-3p in the mnLC group was significantly higher than that in the BLN and healthy groups ([Formula: see text] 0.01). In lung cancer cell lines, miR-412-3p can negatively regulate the targeted gene TEAD1. The miR-412-3p/TEAD1 signaling axis is involved in promoting the EMT signaling pathway and regulating the malignant biological functions of lung cancer cell proliferation, migration, and stemness ([Formula: see text] 0.05). In addition, sEVs in the mnLC group significantly promoted lung cancer cell proliferation, migration, and stemness compared to the BLN and healthy groups, inhibited the expression of E-cadherin and TEAD1 in lung cancer cells, and promoted the expression of N-cadherin and Vimentin ([Formula: see text] 0.05).

CONCLUSION:

sEVs-miR-412-3p could promote the biological process of EMT, and lead to the occurrence of malignant biological behavior in sub-centimeter lung nodules. This provides evidence for the miR-412-3p/TEAD1 signaling axis as a potential therapeutic target for mnLC.
Rosuvastatin inhibit ox-LDL-induced platelet activation by the p38/MAPK pathway
Authors: Liu Jinming , Jiao Wei , Li Fang , Xie Yanan , Meng Mingjie , Hao Jie
Published: September 2024

OBJECTIVE: This study intends to explore the effects of Rosuvastatin on ox-LDL induced platelet activation and its molecular mechanism. METHODS: Platelet aggregation rate was detected by aggregometer. ELISA kit was used to detect the levels of cAMP. Immunofluorescence staining was used to detect the platelet adhesion. The expression levels of platelet surface markers CD62p and PAC-1 were detected by flow cytometry. The protein levels of p-p38, p-IKKa and p-IKKB in platelets were detected by western blot. RESULTS: We found that rosuvastatin significantly inhibited platelet aggregation and increased the level of cAMP in a dose-dependent manner. Immunofluorescence staining results showed that rosuvastatin could inhibit platelet adhesion. Flow cytometry results showed that rosuvastatin could reduce the expression of platelet activation markers. Western blot results showed that rosuvastatin could down-regulate the expression levels of p-p38, p-IKKa and p-IKKb. CONCLUSION: Our study revealed the rosuvastatin could inhibit the aggregation, adhesion and activation of platelet induced by ox-LDL, its mechanism may be related to inhibition of p38/MAPK signal pathway.
On Complexity Bounds and Confluence of Parallel Term Rewriting*
Authors: Baudon Thaïs , Fuhs Carsten , Gonnord Laure
Published: September 2024

We revisit parallel-innermost term rewriting as a model of parallel computation on inductive data structures and provide a corresponding notion of runtime complexity parametric in the size of the start term. We propose automatic techniques to derive both upper and lower bounds on parallel complexity of rewriting that enable a direct reuse of existing techniques for sequential complexity. Our approach to find lower bounds requires confluence of the parallel-innermost rewrite relation, thus we also provide effective sufficient criteria for proving confluence. The applicability and the precision of the method are demonstrated by the relatively light effort in extending the program analysis tool APROVE and by experiments on numerous benchmarks from the literature.
A Drug Repositioning Approach Reveals Ergotamine May Be a Potential Drug for the Treatment of Alzheimer’s Disease
Authors: Wang Qiuchen , Fu Mengjie , Gao Lihui , Yuan Xin , Wang Ju
Published: September 2024

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder that is the most common form of dementia in the elderly. The drugs currently used to treat AD only have limited effects and are not able to cure the disease. Drug repositioning has increasingly become a promising approach to find potential drugs for diseases like AD. Objective: To screen potential drug candidates for AD based on the relationship between risk genes of AD and drugs. Methods: We collected the risk genes of AD and retrieved the information of known drugs from DrugBank. Then, the AD-related genes and the targets of each drug were mapped to the human protein-protein interaction network (PPIN) to represent AD and the drugs on the network. The network distances between each drug and AD were calculated to screen the drugs proximal to AD-related genes on PPIN, and the screened drug candidates were further analyzed by molecular docking and molecular dynamics simulations. Results: We compiled a list of 714 genes associated with AD. From 5,833 drugs used for human diseases, we identified 1,044 drugs that could be potentially used to treat AD. Then, amyloid-β (Aβ) protein, the key molecule involved in the pathogenesis of AD was selected as the target to further screen drugs that may inhibit Aβ aggregation by molecular docking. We found that ergotamine and RAF-265 could bind stably with Aβ. In further analysis by molecular dynamics simulations, both drugs exhibited reasonable stability. Conclusions: Our work indicated that ergotamine and RAF-265 may be potential candidates for treating AD.
The Relationship Between Physical Activity and Non-Modifiable Risk Factors on Alzheimer’s Disease and Brain Health Markers: A UK Biobank Study
Authors: Spencer Felicity S.E. , Elsworthy Richard J. , Breen Leigh , Bishop Jonathan , Morrissey Sol , Aldred Sarah
Published: September 2024

Background: Modifiable (physical activity) and non-modifiable (sex and genotype) risk factors interact to affect Alzheimer’s disease (AD) risk. Further investigation is necessary to understand if these factors influence brain volume and cognition. Objective: The study aimed to assess the effect of physical activity, APOE genotype, and sex on AD risk, brain volume, and cognition. Methods: UK Biobank data from 2006 to 2023 was accessed. Physical activity was measured by accelerometers, and International Physical Activity Questionnaire. Outcomes were AD incidence; brain volume (ventricular cerebrospinal fluid and total brain); and cognition (executive function, memory, visuospatial ability, processing speed, and reaction time). Logistic and linear regression models were conducted. Results: 69,060 participants met inclusion criteria (mean age: 62.28 years, SD: 7.84; 54.64% female). Higher self-reported (OR = 0.63, 95% CI [0.40, 1.00], p = 0.047) and accelerometer-assessed (OR = 0.96 [0.93, 0.98], p = 0.002) physical activity was associated with lower disease incidence. Smaller ventricular cerebrospinal fluid volume (β= – 65.43 [– 109.68, – 17.40], p = 0.007), and larger total brain volume (β= 4398.46 [165.11, 8631.82], p < 0.001) was associated with increased accelerometer-assessed and self-reported physical activity respectively. Both brain volume analyses were moderated by sex. Increased accelerometer-assessed physical activity levels were associated with faster reaction time (β= – 0.43 [– 0.68, – 0.18], p = 0.001); though poorer visuospatial ability (β= – 0.06 [– 0.09, – 0.03], p < 0.001), and executive function (β= 0.49 [0.31, 0.66], p < 0.001; β= 0.27 [0.10, 0.45], p = 0.002) was related to self-reported physical activity levels. Conclusions: Higher levels of physical activity reduce AD risk independently of non-modifiable risk factors. Moderation of sex on brain volume highlighted the importance of incorporating non-modifiable risk factors in analysis.
Altered Neuronal Activity Patterns of the Prefrontal Cortex in Alzheimer’s Disease After Transcranial Alternating Current Stimulation: A Resting-State fMRI Study
Authors: Wang Tao , Yan Shaozhen , Shan Yi , Xing Yi , Bi Sheng , Chen Zhigeng , Xi Hanyu , Xue Hanxiao , Qi Zhigang , Tang Yi , Lu Jie
Published: September 2024

Background: Transcranial alternating current stimulation (tACS) could improve cognition in patients with Alzheimer’s disease (AD). However, the effects of tACS on brain activity remain unclear. Objective: The purpose is to investigate the change in regional neuronal activity after tACS in AD patients employing resting-state functional magnetic resonance imaging (rs-fMRI). Methods: A total of 46 patients with mild AD were enrolled. Each patient received 30 one-hour sessions of real or sham tACS for three weeks (clinical trial: NCT03920826). The fractional amplitude of low-frequency fluctuations (fALFF) and the regional homogeneity (ReHo) measured by rs-fMRI were calculated to evaluate the regional brain activity. Results: Compared to baseline, AD patients in the real group exhibited increased fALFF in the left middle frontal gyrus-orbital part and right inferior frontal gyrus-orbital part, as well as increased ReHo in the left precentral gyrus and right middle frontal gyrus at the end of intervention. At the 3-month follow-up, fALFF increased in the left superior parietal lobule and right inferior temporal gyrus, as well as ReHo, in the left middle frontal gyrus and right superior medial frontal gyrus. A higher fALFF in the right lingual gyrus and ReHo in the right parahippocampal gyrus were observed in the response group than in the nonresponse group. Conclusions: The findings demonstrated the beneficial effects of tACS on the neuronal activity of the prefrontal cortex and even more extensive regions and provided a neuroimaging biomarker of treatment response in AD patients.
Toward Quantitative Neurology: Sensors to Assess Motor Deficits in Dementia
Authors: Hamedani Mehrnaz , Caneva Stefano , Mancardi Gian Luigi , Alì Paolo Alessandro , Fiaschi Pietro , Massa Federico , Schenone Angelo , Pardini Matteo
Published: September 2024

Background: Alzheimer’s disease (AD) is the most common neurodegenerative disorder which primarily involves memory and cognitive functions. It is increasingly recognized that motor involvement is also a common and significant aspect of AD, contributing to functional decline and profoundly impacting quality of life. Motor impairment, either at early or later stages of cognitive disorders, can be considered as a proxy measure of cognitive impairment, and technological devices can provide objective measures for both diagnosis and prognosis purposes. However, compared to other neurodegenerative disorders, the use of technological tools in neurocognitive disorders, including AD, is still in its infancy. Objective: This report aims to evaluate the role of technological devices in assessing motor involvement across the AD spectrum and in other dementing conditions, providing an overview of the existing devices that show promise in this area and exploring their clinical applications. Methods: The evaluation involves a review of the existing literature in the PubMed, Web of Science, Scopus, and Cochrane databases on the effectiveness of these technologies. 21 studies were identified and categorized as: wearable inertial sensors/IMU, console/kinect, gait analysis, tapping device, tablet/mobile, and computer. Results: We found several parameters, such as speed and stride length, that appear promising for detecting abnormal motor function in MCI or dementia. In addition, some studies have found correlations between these motor aspects and cognitive state. Conclusions: Clinical application of technological tools to assess motor function in people with cognitive impairments of a neurodegenerative nature, such as AD, may improve early detection and stratification of patients.
Clinical correlates of cerebellar injury in preterm infants with surgical necrotizing enterocolitis
Authors: Garg P.M. , Pittman I. , Yi J. , Shetty A. , Taylor C. , Reddy K. , Inder T.E. , Varshney N. , Hillegass W.B. , Garg P.P.
Published: September 2024

BACKGROUND: The preterm infants are at risk of cerebellar injury and the risk factors for necrotizing enterocolitis (NEC) associated cerebellar injury are not fully understood. AIM: Determine the risk factors of cerebellar injury in infants with surgical necrotizing enterocolitis (NEC). METHODS: Retrospective study compared clinical/pathological information between surgical NEC infants with and those without cerebellar injury detected on brain MRI obtained at term equivalent age. Cerebellar Injury patterns that we identified on MRI brain were cerebellar hemorrhage, siderosis and/or cerebellar volume loss. RESULTS: Cerebellar injury (21/65, 32.3%) in preterm infants with NEC was associated with patent ductus arteriosus (PDA) (18/21(85.7%) vs. 25/44(56.8%); p = 0.021), blood culture positive sepsis (13/21 (61.9%) vs. 11/44 (25%); p = 0.004) following NEC, predominantly grew gram positive bacteria (9/21(42.9%) vs. 4/44(9.1%); p = 0.001), greater red cell transfusion, higher rates of cholestasis following NEC and differences in intestinal histopathology (more hemorrhagic and reparative lesions) on univariate analysis. Those with cerebellar injury had higher grade white matter injury (14/21 (66.7%) vs. 4/44(9.1%) p = 0.0005) and higher-grade ROP (70.6% vs. 38.5%; p = 0.027) than those without cerebellar injury. On multilogistic regression, the positive blood culture sepsis (OR 3.9, CI 1.1–13.7, p = 0.03), PDA (OR 4.5, CI 1.0–19.9, p = 0.04) and severe intestinal pathological hemorrhage (grade 3-4) (OR 16.9, CI 2.1–135.5, p = 0.007) were independently associated with higher risk of cerebellar injury. CONCLUSION: Preterm infants with surgical NEC with positive blood culture sepsis, PDA, and severe intestinal hemorrhagic lesions (grade 3-4) appear at greater risk for cerebellar injury.
Does diagnosis matter? Evaluating impact of pediatric chronic pain diagnosis on pain and function
Authors: Vernacchia Cara , Amstutz Diane , Petrie Benjamin , Gohil Kavita , Revivo Gadi
Published: September 2024

PURPOSE: This study aimed to A) evaluate changes in pain and function following an outpatient interdisciplinary pain management program (IPMP) for children with different chronic pain conditions and B) explore differences in pain and function at baseline and discharge for different diagnoses. METHODS: A retrospective chart review was performed for 488 children who participated in an outpatient IPMP. Children’s pain and physical, social, and emotional functioning were assessed at initial evaluation, discharge, and one-to-two-month follow-up. Patients were stratified by diagnosis (complex regional pain syndrome [CRPS], headache, musculoskeletal pain, visceral pain, and widespread pain) to evaluate differences in pain and functioning at baseline and discharge. RESULTS: Children’s pain and function improved from initial evaluation to discharge. Those with headache and musculoskeletal pain exhibited better baseline physical and emotional functioning than other diagnostic groups (p = 0.03; p = 0.005; p = 0.002; p = 0.04). Children with CRPS displayed the worst baseline physical functioning (p = 0.003). Those with widespread pain exhibited the worst baseline emotional functioning at both initial evaluation and discharge (p = 0.009; p = 0.007). CONCLUSION: Children with CRPS, visceral pain, and widespread pain undergoing treatment in an IPMP exhibited the most impaired baseline functioning, while those with musculoskeletal pain and headache were least impaired. All exhibited improvements in pain and function following the IPMP.
The value and accuracy of intracoronary electrocardiogram in the diagnosis of myocardial ischemia in coronary heart disease
Authors: Zhang Shanwen , Bao Zhimin , Liao Taotao , Pei Zhenying , Yang Shiyu , Zhao Chunjiao , Zhang Yuping
Published: September 2024

BACKGROUND:

Although intracoronary electrocardiography (IC-ECG) offers direct electrophysiological insights into myocardial ischemia caused by insufficient coronary blood supply, compared to common diagnostic methods like electrocardiography (ECG), it lacks widespread adoption and robust clinical research.

OBJECTIVE:

To analyze the value and accuracy of intracoronary electrocardiogram in myocardial ischemia diagnosis in coronary heart disease patients.

METHODS:

Three hundred patients treated at our hospital were included in the study. Patients were categorized into non-ischemic group A (Fraction Flow Reserve [FFR] [Formula: see text] 0.8) and ischemic group B (FFR [Formula: see text] 0.75) based on FFR examination results. Both groups underwent IC-ECG examination. The ischemic group received percutaneous coronary intervention (PCI) treatment followed by another FFR examination, dividing them into non-ischemic subgroup B1 (FFR [Formula: see text] 0.8) and ischemic subgroup B2 (FFR [Formula: see text] 0.75). Both subgroups underwent IC-ECG examination. Receiver operating curves were constructed using FFR to assess the clinical utility of different IC-ECG parameters.

RESULTS:

Group A patients showed a significant decrease in ST-segment shift at J-point, ST-segment integral, T-peak, T-wave integral, and T-peak to end-time, while the Corrected Q-T interval (QTc-time) was significantly higher in the B group ([Formula: see text] 0.05). The parameters, including ST-segment shift at J-point, ST-segment integral, T-wave integral, T-peak, T-peak to end-time, and QTc-time, were found to have clinical significance in predicting the occurrence of myocardial ischemia ([Formula: see text] 0.05).

CONCLUSION:

Intracoronary electrocardiogram QT interval dispersion and Q-T peak (QTp) interval dispersion have a high diagnostic accuracy for myocardial ischemia in coronary heart disease.
Influence of different forms of folic acid supplementation on pregnancy outcomes under various exposure factors
Authors: Song Jie , Lan Ruihong , Yin Dahua , Wang Ling , Gong Humin
Published: September 2024

BACKGROUND:

Folic acid supplementation has been shown to provide benefits in preventing neural tube defects and other birth defects, as well as reducing adverse pregnancy outcomes.

OBJECTIVE:

This study aimed to examine the impact of various folic acid supplementation methods on pregnancy.

METHODS:

TaqMan-MGB technology was used to detect polymorphisms in the folate metabolism-related genes, MTHFR C677T and A1298C. Blood-related biochemical indicators, including HCY levels and history of adverse pregnancy, were examined in relation to different exposure factors (MTHFR gene polymorphism, HCY levels, and adverse pregnancy history) and their impact on pregnancy outcomes. Various forms of folic acid intervention were implemented in a population with an adverse pregnancy history and high HCY levels to analyze the effects of reducing HCY levels and improving pregnancy outcomes.

RESULTS:

Exposure factors, such as adverse pregnancy history, HCY, and medium-to-high risk of gene metabolism, were closely associated with pregnancy outcomes. Interestingly, methylfolate efficiently reduced the serum HCY levels. More importantly, the methylfolate group exhibited a significantly lower incidence of adverse pregnancies than the synthetic folic acid group.

CONCLUSION:

In this study, the risk factors, including adverse pregnancy history, HCY, and medium-to-high risk of gene metabolism, were confirmed to lead to the poorer pregnancy outcomes in our cohort. 5-methyltetrahydrofolate may be an effective approach for decreasing the incidence of adverse pregnancy outcomes.
Continuous glucose monitoring using machine learning models and IoT device data: A meta-analysis
Authors: Kapoor Yagyesh , Hasija Yasha
Published: September 2024

BACKGROUND:

Machine learning offers diverse options for effectively managing blood glucose levels in diabetes patients. Selecting the right ML algorithm is critical given the array of available choices. Integrating data from IoT devices presents promising opportunities to enhance real-time blood glucose management models.

OBJECTIVE:

This meta-analysis aims to evaluate the effectiveness of machine learning models utilizing IoT device data for predicting blood glucose levels.

METHODS:

We systematically searched electronic databases for studies published between 2019 and 2023. We excluded studies lacking ML model derivation or performance metrics. The Quality Assessment of Diagnostic Accuracy Studies tool assessed study quality. Our primary outcomes compared ML models for BG level prediction across different prediction horizons (PHs).

RESULTS:

We analyzed ten eligible studies across prediction horizons of 15, 30, 45, and 60 minutes. ML models exhibited mean absolute RMSE values of 15.02 (SD 1.45), 21.488 (SD 2.92), 30.094 (SD 3.245), and 35.89 (SD 6.4) mg/dL, respectively. Random Forest demonstrated superior performance across these PHs.

CONCLUSION:

We observed significant heterogeneity across all subgroups, indicating diverse sources of variability. As the PH lengthened, the RMSE for blood glucose prediction by the ML model increased, with Random Forest showing the highest relative performance among the ML models.
Echinacoside inhibits hepatocellular carcinoma progression by targeting the miR-30c-5p/FOXD1/KLF12 axis
Authors: Wang Guoyu , Han Yang , Zhuang Juhua , Mai Zhongchao , Xia Wei , Ye Ying
Published: September 2024

BACKGROUND:

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-attributed mortality and the primary liver malignancy in the world. Echinacoside is a phenylethanoid glycoside derived from traditional Chinese medicinal herbs which possessed multiple health benefits on humans, including anti-tumor effects.

OBJECTIVE:

This study aimed to demonstrate the function of echinacoside in HCC progression and the involvement of miR-30c-5p/FOXD1/KLF12 axis.

METHODS:

The HepG2 cells were treated by different dose of echinacoside, miR-30c-5p mimic, miR-30c-5p inhibitor, and FOXD1 overexpression lentiviruses or siRNA individually or simultaneously. The cell invasion and migration were measured by transwell assay. RNA and protein levels were tested by RT-PCR and western blot, respectively. The regulatory function of miR-30c-5p on Forkhead box D1 (FOXD1), FOXD1 on Krüppel-like factor 12 (KLF12) was tested by luciferase reporter assay or/and ChIP assay. Meanwhile, a liver cancer lung metastasis mice model was used to examine the functions of echinacoside and miR-30c-5p on HCC metastasis in vivo. Moreover, the correlations among miR-30c-5p, FOXD1, KLF12, and HCC prognosis was analyzed using clinical sample and TCGA database.

RESULTS:

Based on both in vitro and in vivo investigations, we found that echinacoside could inhibit HCC cell migration, invasiveness, and tumor metastasis, and associated with the enhanced miR-30c-5p/FOXD1/KLF12 axis. Furthermore, through analyzing the interactions among intermediate molecules, we revealed that miR-30c-5p, FOXD1, and KLF12üere clinically relevant with each other in HCC patients, correlated with HCC prognosis, and regulated by echinacoside to contribute in the inhibition of HCC progression.

CONCLUSIONS:

These findings suggest that echinacoside could inhibit HCC progression, and the mechanism related to the enhanced miR-30c-5p/FOXD1/KLF12 axis. Moreover, the abovementioned intermediate molecules might serve as prospective biomarkers for HCC prognosis.
A comprehensive guide to content-based image retrieval algorithms with visualsift ensembling
Authors: Ramesh Babu Durai C. , Sathesh Raaj R. , Sekharan Sindhu Chandra , Nishok V.S.
Published: September 2024

BACKGROUND: Content-based image retrieval (CBIR) systems are vital for managing the large volumes of data produced by medical imaging technologies. They enable efficient retrieval of relevant medical images from extensive databases, supporting clinical diagnosis, treatment planning, and medical research. OBJECTIVE: This study aims to enhance CBIR systems’ effectiveness in medical image analysis by introducing the VisualSift Ensembling Integration with Attention Mechanisms (VEIAM). VEIAM seeks to improve diagnostic accuracy and retrieval efficiency by integrating robust feature extraction with dynamic attention mechanisms. METHODS: VEIAM combines Scale-Invariant Feature Transform (SIFT) with selective attention mechanisms to emphasize crucial regions within medical images dynamically. Implemented in Python, the model integrates seamlessly into existing medical image analysis workflows, providing a robust and accessible tool for clinicians and researchers. RESULTS: The proposed VEIAM model demonstrated an impressive accuracy of 97.34% in classifying and retrieving medical images. This performance indicates VEIAM’s capability to discern subtle patterns and textures critical for accurate diagnostics. CONCLUSIONS: By merging SIFT-based feature extraction with attention processes, VEIAM offers a discriminatively powerful approach to medical image analysis. Its high accuracy and efficiency in retrieving relevant medical images make it a promising tool for enhancing diagnostic processes and supporting medical research in CBIR systems.
Platinum(II) complexes based on derivatives of natural chlorins with pyridine-containing chelate groups as prototypes of drugs for combination therapy in oncology
Authors: Kirin N. S. , Ostroverkhov P. V. , Usachev M. N. , Birin K. P. , Grin M. A.
Published: September 2024

Objectives. To synthesize Pt-containing derivatives of natural chlorins as potential agents for the combination therapy in oncology. Platinum compounds are known to occupy an important place as chemotherapeutic agents in the treatment of oncological diseases. However, Pt(II) complexes are highly toxic to the body and are not selectively accumulated in tumor cells. If photodynamic and chemotherapy methods are combined in a single drug, the pigments are responsible for the selectivity of conjugate accumulation in the tumor, while a chemotherapeutic agent based on Pt(II) complexes is responsible for the cytotoxic effect on tumor cells. This will not affect healthy cells and thereby minimize the systemic toxicity of the drug to the body.

Methods. Methods for the synthesis of pyridine-containing derivatives of natural chlorins and their metal complexes for use as potential binary agents in oncology were applied. As part of the study, the structures of the compounds obtained were confirmed by mass spectrometry, nuclear magnetic resonance spectroscopy, ultraviolet spectroscopy, and high-resolution chromatography-mass spectrometry. Preparative methods, including thin-layer and column chromatography, centrifugation and recrystallization, were used to isolate and purify the compounds obtained.

Results. Platinum(II) complexes of pyridine-containing derivatives of natural chlorins were obtained for application in combination therapy in oncology. The schemes for synthesizing the target photosensitizers were optimized, in order to increase the yields and for subsequent transfer to industrial sites.

Conclusions. It was found that pyridine-containing derivatives of natural chlorins could be obtained in high yields, that they possess chelating properties for platinum, and can be considered as binary agents in cancer therapy after successful preclinical trials.
N-[(1RS)-Camphan-2-ylidene]-4-ethoxyaniline and its reduction product as stabilizers of nitrile butadiene rubbers
Authors: Nilidin D. A. , Vaniev M. A. , Vernigora A. A. , Davidenko A. V. , Salykin N. A. , Minh Thuy Dang , Gubin S. G. , Novakov I. A.
Published: September 2024

Objectives. To investigate the protective efficacy of unreduced and reduced forms of the condensation product of D,L-camphor and p-ethoxyaniline in nitrile butadiene rubber formulations when compared with the conventional stabilizer N-isopropyl-N′-phenyl- p-phenylenediamine aged under laboratory and in situ climatic conditions in the tropics.

Methods. The thermostabilizing effect of the condensation product of D,L-camphor and p-ethoxyaniline was evaluated by means of infrared spectroscopy using the dynamics of changes in the absorption bands of carbonyl and hydroxyl groups. The features of rubber vulcanization were studied by means of rotorless rheometry. Changes in the physical and mechanical properties of rubbers and degree of cross-linking were evaluated after thermo-oxidative aging in laboratory conditions. They also took into account the results of longterm exposure of samples in undeformed and deformed state in a tropical climate, taking into account meteorological data of the Can Gio climatic testing station.

Results. It was found for the first time that condensation products of D,L-camphor and p-ethoxyaniline exhibit a stabilizing effect in formulations of rubbers based on polar nitrile butadiene rubber.

Conclusions. According to the results of laboratory and in situ tests, the study established that the use of N-[(1RS,2RS)-camphan-2-yl]- 4-ethoxyaniline (reduced form) as an antifatigue agent is preferable. This is due to the presence of a mobile hydrogen atom at the nitrogen atom. The protective effect is manifested in terms of the better preservation of elastic-strength properties of rubbers with less change in hardness.
Creative Activity of the Inso-Lviv Academic Symphony Orchestra in the Context of Development of Musical Culture of Ukraine and Modern Cultural Creation
Authors: Nobuhiro Terada
Published: September 2024

The purpose of the work is to investigate the artistic and creative activities of the Academic Symphony Orchestra of the Lviv Philharmonic "INSO-Lviv" in the context of the development of modern classical musical art and cultural trends mediated by the dynamics of socio-cultural processes. The research methodology includes interdisciplinary and systemic approaches, as well as scientific methods: analytical, art history, culture studies, with the help of which the research goal was achieved and the conclusions obtained. The scientific novelty of the work lies in the fact that for the first time the artistic and creative activity of the Academic Symphony Orchestra "INSO-Lviv" is considered in the projection of the development of modern classical music and modern cultural creation, and the main creative achievements of the collective are outlined. Conclusions. Academic symphony orchestra "INSO-Lviv" continues to develop, maintaining high performance skills and expanding its creative horizons, while making a significant contribution to the modern cultural and creative process and forming a high level of Ukrainian musical culture and drawing the attention of the international community to the war in Ukraine. The "INSO-Lviv" orchestra is an important element of the cultural life of Lviv and Ukraine, which contributes to the enrichment of the country's cultural life. Their high skill, wide repertoire and active participation in international projects make them one of the leading musical groups in Ukraine. Thanks to its activities, the orchestra promotes the popularization of classical and modern music, supports cultural initiatives and is an important part of the musical world. The orchestra also plays a key role in the festival cultural life of Ukraine, being not only a participant in many important musical events, but also actively contributing to the development of current cultural trends. They represent a high level of musical performance and promote cultural exchange at both the national and international levels.
"East-West" Dialogue in Chinese Chamber-Instrumental Music: The Case of Wang Xilin and Wang Ying
Authors: Ding Zhuxiang
Published: September 2024

The purpose of the research is to study and analyse the chamber-instrumental creativity of Chinese composers through the lens of the East-West dialogue, using the works of Wang Xilin and Wang Ying as examples. The research methodology is based on comparative analysis of musical compositions, examination of musical scores, as well as interviews with composers and musicologists. Musical analysis methods are utilised to identify specific features and influences in the works of Wang Xilin and Wang Ying. The scientific novelty of the research lies in the first detailed analysis of the chamber-instrumental works of Wang Xilin and Wang Ying in the context of the dialogue between Eastern and Western musical traditions. Conclusions. The study reveals how composers synthesise elements of national Chinese music with European influences, creating unique musical works that represent a new dimension in contemporary chamber music in China. Special attention is given to the creative legacy of Wang Xilin, a renowned master of chamber music, and his daughter Wang Ying, an original composer of the new generation. Their contribution to the development of chamber-instrumental music is discussed, as well as the specifics of their musical approaches reflecting the dialogue between Eastern and Western musical traditions. The article provides a detailed analysis of their most notable chamber works, demonstrating a unique synthesis of Chinese national elements with European influences, thereby providing a new dimension to contemporary chamber music in China. For Wang Xilin, as a representative of the older generation, significant concepts and depth of thought were important in solving classical formal tasks. His innovations consisted of creating significant examples of chamber-instrumental music comparable in seriousness to large symphonic works. For Wang Ying, a composer of the “millennial” generation, innovation, and independence in creative decisions become the main priorities. They strive for experiments with non-standard instrumental ensembles, new composition techniques, unexpected sound effects, the use of electronics, microchromatics, improvisation, and open forms.
Lemki Folklore as "Ethnocultural Sign" in Modern Pop Interpretations: Conceptual Prerequisites of the Study
Authors: Torkoniak Nataliia
Published: September 2024

The purpose of the article is to substantiate the conceptual prerequisites for the interpretation of Lemki folklore as an “ethnocultural sign” in pop interpretations. The research methodology is based on general scientific methods of analysis (historical, semiological, cultural) and generalisation in the context of an interdisciplinary approach, which made it possible to conceptualise the idea of Lemkivshchyna as a “memory place”, Lemkiv folklore as an “ethnocultural sign” and to establish a hierarchical system of its reflection in pop interpretations. The scientific novelty consists in the interpretation of Lemki folklore as an “ethno-cultural sign”, the explanation this concept, certain ideas of socio-cultural concepts in the pop studies field. An author’s system of displaying ethnocultural symbolism in pop interpretations is proposed. Conclusions. The continuity of Lemkivshchyna phenomenon as a “memory place” is supported by performances of folklore samples in the interpretive range from authentic to transformational. Despite the new stylistics, they are designed to preserve the small homeland semantics as a sign that is manifested at different hierarchical levels: intonation (1), lexical (2), genre (3), performance manner (4), Lemki folklore syncretic system (5). The latter is a generalised “sign” that represents the mentality of the ethnic group and creates the “Lemki myth”.
Das Wesentliche ist für die amtliche Statistik unsichtbar. Erkenntnisse aus der Jugendarbeitsstatistik „Jugend zählt 2“ zur Situation in evangelischen Jugendverbänden und Kirchengemeinden
Authors: Ilg Wolfgang , Hintzenstern Anika , Sigle Luca
Published: September 2024

Im ersten Beitrag teilen Wolfgang Ilg, Anika Hintzenstern und Luca Sigle einige Befunde der statistischen Studie „Jugend zählt 2“ mit, die sich mit der Situation der evangelischen Jugendarbeit in Verbänden und Kirchengemeinden Baden-Württembergs befasst hat. Die Studie zeigt, wie unvollständig die offizielle amtliche Statistik zur Kinder- und Jugendarbeit ist; denn ein Großteil der zumeist ehrenamtlichen Basisarbeit vor Ort wird dort nicht sichtbar. Die neue Studie dagegen bildet auch diesen Bereich ab und sorgt damit für eine stärkere öffentliche Wahrnehmung der Jugendarbeit. Vorgestellt werden in dem Beitrag zentrale Ergebnisse der Studie u.a. in den Bereichen Ehrenamt, Inklusion und öffentliche Förderung. Bemerkenswert ist der Befund, dass sechs von sieben Jugendgruppen keinerlei öffentliche Förderung erhalten. Eine Förderung der wenig öffentlichkeitswirksamen regelmäßigen Gruppenarbeit mit Kindern und Jugendlichen sei offensichtlich kaum etabliert, so Ilg u.a.. Das sei kein Wunder; denn lediglich 3,32% der Jugendhilfe-Ausgaben entfielen auf die Jugendarbeit. Auch bei den Ausgabenzuwächsen würden Jugendsozialarbeit oder Kindertagesbetreuung sehr gut bedacht, die Zuwächse der Jugendarbeit könnten aber nicht einmal die Inflation ausgleichen. Die Autoren und die Autorin befürchten, dass diese Situation es für Ehrenamtliche immer mühsamer macht, ihr Engagement aufrechtzuerhalten.
Aktuelle Jugendprobleme verstehen: Transnationale Jugendgangs. Eine neue Auseinandersetzung mit Isolation und Aggression ist an der Zeit
Authors: Benedikter Roland
Published: September 2024

Mit transnationalen Jugendgangs, die sich jenseits traditioneller Verbandsstrukturen dynamisch entwickeln, beschäftigt sich Roland Benedikter im Beitrag. Der Autor stützt sich bei seinen Ausführungen auf Ergebnisse des EU-Projekts TRANSGANG. Gangs oder „Tribes“ dieser Art entwickeln sich – ohne die Einbindung in die Werte und Strukturen von Verbänden – entweder in Richtung Hordenbildung, Selbstisolation und Gewalt oder in Richtung kultureller Identitätsgruppen. Der Autor ordnet diese Entwicklungen gesellschaftlich ein und entwickelt auf dieser Basis konzeptionelle Grundlagen für Handlungsperspektiven.
Sozial-ökologische Transformation in der Evangelischen Jugendverbandsarbeit
Authors: Lederer Henrike
Published: September 2024

Vielfältige Aktivitäten der evangelischen Jugendarbeit zur sozial-ökologischen Transformation stehen im Mittelpunkt des zweiten Beitrags. Henrike Lederer berichtet, was dazu in der Arbeitsgemeinschaft der Evangelischen Jugend (aej) entwickelt worden ist. Sie beschreibt den Weg der aej hin zu einer Kultur der Nachhaltigkeit, gibt einen kurzen Überblick über das Engagement in der aej, berichtet von zentralen Nachhaltigkeitsbeschlüssen des evangelischen Dachverbandes und stellt exemplarisch Umsetzungsbeispiele einzelner aej-Untergliederungen vor. Dabei stehen folgende Fragen im Mittelpunkt: Welchen Stellenwert hat die sozial-ökologische Transformation in der Evangelischen Jugendverbandsarbeit? Welche Maßnahmen und Herangehensweisen gibt es dort bereits? Wie sollte das Engagement weitergeführt werden? Bei ihren Ausführungen geht die Autorin u.a. auf Konzepte, Materialien und Vorlagen aus den Mitgliedsverbänden der aej ein.
Zurückgeschoben und inhaftiert – Kinder und Jugendliche und das europäische Grenzregime
Authors: Eckert Sophia , Wilmes Teresa
Published: September 2024

An den Außengrenzen der Europäischen Union werden seit Jahren täglich Menschen- und Kinderrechte verletzt. Für hunderttausende Kinder und Jugendliche auf der Flucht bedeutet das physische und psychische Gewalterfahrungen, Freiheitsentzug und Familientrennungen. Die Reform des Gemeinsamen Europäischen Asylsystems wird daran nichts ändern: Sie wird vielmehr die vorhandenen Missstände weiter verschärfen. Die Autorinnen belegen dies anhand von Erfahrungen der Partner*innen-Organisationen von terre des hommes an den Grenzen von Griechenland, Bulgarien, Ungarn und Polen.
Unterstützte Beschäftigung – Status Quo und Entwicklungspotentiale in der beruflichen Rehabilitation
Authors: Jochmaring Jan , York Jana
Published: September 2024

Der Beitrag skizziert zunächst das Konzept der Unterstützten Beschäftigung sowie die sozialpolitische Implementierung des Instrumentes (2). Anschließend werden bestehende Instrumente der beruflichen Rehabilitation systematisiert und die Unterstützte Beschäftigung in diesem Kanon verortet (3). Nachfolgend werden denkbare Entwicklungsszenarien und -potentiale durch den Einsatz Assistiver Technologien sowie durch die Ausweitung von Rechtsansprüchen expliziert (4).
Inklusionsbetriebe. Entwicklung, Aufgaben und Kennzahlen – mit Vorstellung der Informa gGmbH aus Neuwied
Authors: Daniel Marcel
Published: September 2024

Inklusionsbetriebe. Entwicklung, Aufgaben und Kennzahlen – mit Vorstellung der Informa gGmbH aus Neuwied
Editorial
Authors: Lindmeier Bettina , Imholz Susanne , Meyer Dorothee
Published: September 2024

Editorial
„Unterschiedlich und gleich viel wert.“
Authors: Hill Philipp , Imholz Susanne
Published: September 2024

Interview Philipp Hill & Susanne Imholz
Rassismus gegen Schwarze Menschen in Deutschland, Frankreich und Kanada. Bewältigungs- und Widerstandspraktiken im urbanen und periurbanen Raum
Authors: Hilscher Annette
Published: September 2024

Trotz eines normativen Konsenses über die Unzulässigkeit von Rassismus und infolgedessen der Anerkennung eines allgemeinen Gleichbehandlungsgrundsatzes erfahren Schwarze Menschen in Deutschland, Frankreich und Kanada weiterhin Alltagsrassismus. Diese Diskrepanz zwischen den normativen Grundlagen und der sozialen Lebensrealität stellt den Ausgangspunkt für eine qualitativ-rekonstruktive Studie dar. Mit der Dokumentarischen Methode wurden Gruppendiskussionen und biographisch-narrative Interviews mit Schwarzen Menschen in den drei Ländern erhoben. Bei der Auswertung haben sich je nach Zugehörigkeit zu einem Sozialraum, hier dem urbanen und dem periurbanen, Unterschiede sowohl hinsichtlich des Erlebens der Rassismuserfahrung, als auch hinsichtlich der Bewältigungs- und Widerstandspraktiken gezeigt.