bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovering Engagement Personas in a Digital Diabetes Prevention Program
Authors: Hori Jonathan H. , Sia Elizabeth X. , Lockwood Kimberly G. , Auster-Gussman Lisa A. , Rapoport Sharon , Branch OraLee H. , Graham Sarah A.
Published: May 2022

Digital health technologies are shaping the future of preventive health care. We present a quantitative approach for discovering and characterizing engagement personas: longitudinal engagement patterns in a fully digital diabetes prevention program. We used a two-step approach to discovering engagement personas among n = 1613 users: (1) A univariate clustering method using two unsupervised k-means clustering algorithms on app- and program-feature use separately and (2) A bivariate clustering method that involved comparing cluster labels for each member across app- and program-feature univariate clusters. The univariate analyses revealed five app-feature clusters and four program-feature clusters. The bivariate analysis revealed five unique combinations of these clusters, called engagement personas, which represented 76% of users. These engagement personas differed in both member demographics and weight loss. Exploring engagement personas is beneficial to inform strategies for personalizing the program experience and optimizing engagement in a variety of digital health interventions.
Perceived Vulnerability to Disease and the Relationship with Teacher Satisfaction in South Africa during COVID-19: The Serial Role of Burnout, Role Conflict, and Ambiguity
Authors: Pretorius Tyrone Brian , Padmanabhanunni Anita , Isaacs Serena Ann , Jackson Kyle
Published: May 2022

Teachers’ work roles and responsibilities have changed dramatically because of the COVID-19 pandemic. These unprecedented changes have the potential to generate role stress and burnout and reduce teachers’ job satisfaction. This study investigated the serial relationship between perceived vulnerability to disease, role stress, burnout, and teaching satisfaction. It was hypothesised that individuals who perceive themselves to be at high risk of contracting COVID-19 would report high role conflict and ambiguity in the workplace, which would in turn lead to high levels of burnout and low satisfaction with teaching. Participants were schoolteachers (N = 355) who completed the Perceived Vulnerability to Disease Questionnaire, the Role Orientation Questionnaire, the Maslach Burnout Inventory, and the Teaching Satisfaction Scale. Path analysis confirmed that perceived vulnerability to disease was associated with role conflict and ambiguity, which was in turn associated with emotional exhaustion, depersonalisation, and low teaching satisfaction. Teachers who appraised themselves as being more vulnerable to contracting COVID-19 experienced greater role stress, which was associated with high levels of burnout and low teaching satisfaction. This study highlights that threat appraisals related to contracting COVID-19 represent an additional job demand and this needs to be matched by job resources that can facilitate coping.
Compressive Strength Prediction of Fly Ash Concrete Using Machine Learning Techniques
Authors: Jiang Yimin , Li Hangyu , Zhou Yisong
Published: May 2022

It is time-consuming and uneconomical to estimate the strength properties of fly ash concrete using conventional compression experiments. For this reason, four machine learning models—extreme learning machine, random forest, original support vector regression (SVR), and the SVR model optimized by a grid search algorithm—were proposed to predict the compressive strength of fly ash concrete on 270 group datasets. The prediction results of the proposed model were compared using five evaluation indices, and the relative importance and effect of each input variable on the output compressive strength were analyzed. The results showed that the optimized hybrid model showed the best predictive behavior compared to the other three models, and can be used to forecast the compressive strength of fly ash concrete at a specific mix design ratio before conducting laboratory compression tests, which will save costs on the specimens and laboratory tests. Among the eight input variables listed, age and water were the two relatively most important features with superplasticizer and fly ash being of weaker relative importance.
A Experimental Study on Engineered Cementitious Composites (ECC) Incorporated with Sporosarcina pasteurii
Authors: Chen Bingcheng , Du Lufei , Yuan Jun , Sun Xichen , Pathirage Madura , Sun Weiwei , Feng Jun
Published: May 2022

Microbial-induced calcium carbonate precipitation (MICP) has been successfully applied to self-healing concrete with improved mechanical properties, while the performance of engineered cementitious composites (ECC) incorporated with bacteria is still lacking. In this study, Sporosarcina pasteurii, which has a strong ability to produce calcium carbonate, was introduced into engineered cementitious composites (ECC) with mechanical properties analyzed in detail. A multiscale study including compression, tension and fiber pullout tests was carried out to explore the Sporosarcina pasteurii incorporation effect on ECC mechanical properties. Compared with the control group, the compressive strength of S.p.-ECC specimens cured for 7 days was increased by almost 10% and the regained strength after self-healing was increased by 7.31%. Meanwhile, the initial crack strength and tensile strength of S.p.-ECC increased by 10.25% and 12.68%, respectively. Interestingly, the crack pattern of ECC was also improved to some extent, e.g., bacteria seemed to minimize crack width. The addition of bacteria failed to increase the ECC tensile strain, which remained at about 4%, in accordance with engineering practice. Finally, matrix/fiber interface properties were altered in S.p.-ECC with lower chemical bond and higher frictional bond strength. The results at the microscopic scale explain well the property improvements of ECC composites based on the fine-scale mechanical theory.
The Effect of Building Electricity Consumption on Residents’ Subjective Well-Being: Evidence from China
Authors: Wu Yidong , Wu Yanbo , Zhang Yalin , Wang Xianzhu , Song Zisheng
Published: May 2022

Residential electricity consumption has an important impact on China’s construction of a low-carbon society. However, at present, little of the literature analyzes the influencing factors of residents’ overall well-being from the perspective of micro investigation. Based on the micro mixed cross section data of the Chinese General Social Survey (CGSS), this paper empirically studies the impact of residential electricity consumption on residents’ subjective well-being. In addition, in the heterogeneity analysis, we found that an increase in residential electricity consumption will improve the overall well-being of females and people with low levels of education, but it has no significant effect on males and people with high levels of education. Moreover, the increase in residential electricity consumption has improved the life satisfaction of young people and middle-aged people. Meanwhile, the increase in residential electricity consumption has a significant, positive impact on both low-income and high-income households. Further analysis shows that no nonlinear relationship exists between the increase in residents’ power consumption and the improvement in life satisfaction. This paper enriches the research on residential energy and provides policy implications for the current Chinese government to save energy, reduce emissions, and improve residents’ quality of life.
Plasma-Enhanced Carbon Nanotube Fiber Cathode for Li-S Batteries
Authors: Fang Yanbo , Hsieh Yu-Yun , Khosravifar Mahnoosh , Adusei Paa Kwasi , Kanakaraj Sathya Narayan , Stockman Bely , Kondapalli Vamsi Krishna Reddy , Shanov Vesselin
Published: May 2022

Fiber-shaped batteries have attracted much interest in the last few years. However, a major challenge for this type of battery is their relatively low energy density. Here, we present a freestanding, flexible CNT fiber with high electrical conductivity and applied oxygen plasma-functionalization, which was successfully employed to serve as an effective cathode for Li-S batteries. The electrochemical results obtained from the conducted battery tests showed a decent rate capability and cyclic stability. The cathode delivered a capacity of 1019 mAh g−1 at 0.1 C. It accommodated a high sulfur loading of 73% and maintained 47% of the initial capacity after 300 cycles. The demonstrated performance of the fiber cathode provides new insights for the designing and fabrication of high energy density fiber-shaped batteries.
Management of Unresectable Localized Pelvic Bone Sarcomas: Current Practice and Future Perspectives
Authors: Soares do Brito Joaquim , Esperança-Martins Miguel , Abrunhosa-Branquinho André , Melo-Alvim Cecilia , Lopes-Brás Raquel , Janeiro João , Lopez-Presa Dolores , Fernandes Isabel , Portela José , Costa Luis
Published: May 2022

Bone sarcomas (BS) are rare mesenchymal tumors usually located in the extremities and pelvis. While surgical resection is the cornerstone of curative treatment, some locally advanced tumors are deemed unresectable and hence not suitable for curative intent. This is often true for pelvic sarcoma due to anatomic complexity and proximity to vital structures, making treatment options for these tumors generally limited and not unanimous, with decisions being made on an individual basis after multidisciplinary discussion. Several studies have been published in recent years focusing on innovative treatment options for patients with locally advanced sarcoma not amenable to local surgery. The present article reviews the evidence regarding the treatment of patients with locally advanced and unresectable pelvic BS, with the goal of providing an overview of treatment options for the main BS histologic subtypes involving this anatomic area and exploring future therapeutic perspectives. The management of unresectable localized pelvic BS represents a major challenge and is hampered by the lack of comprehensive and standardized guidelines. As such, the optimal treatment needs to be individually tailored, weighing a panoply of patient- and tumor-related factors. Despite the bright prospects raised by novel therapeutic approaches, the role of each treatment option in the therapeutic armamentarium of these patients requires solid clinical evidence before becoming fully established.
Association of Diabetes Severity and Mortality with Lung Squamous Cell Carcinoma
Authors: Su Chih-Hsiung , Chen Wan-Ming , Chen Mingchih , Shia Ben-Chang , Wu Szu-Yuan
Published: May 2022

Purpose: The survival impact of diabetes severity on lung cancer remains unclear. We performed head-to-head propensity score matching to estimate the survival impact of various adapted diabetes complications severity index (aDCSI) scores in patients with both diabetes and lung squamous cell carcinoma (SqCLC). Patients and Methods: We enrolled patients with both diabetes and lung SqCLC and categorized them into the mild (aDCSI = 0–1) and moderate-to-severe (aDCSI ≥ 2) diabetes groups. The patients in both groups were matched at a 1:1 ratio. Results: the matching process yielded a final cohort of 5742 patients with both diabetes and lung SqCLC (2871 patients in the mild diabetes group and 2871 patients in the moderate-to-severe diabetes groups) who were eligible for further analysis. A multivariate Cox regression analysis revealed that the adjusted hazard ratio (aHR; 95% confidence interval) of all-cause death for the mild diabetes group relative to the moderate-to-severe diabetes group was 1.17 (1.08–1.28; p = 0.0005). Conclusion: severe diabetes (aDCSI ≥ 2) is an independent prognostic factor for OS among patients with both diabetes and lung SqCLC who receive standard treatments. Preventing diabetes progression is necessary for patients with diabetes because it not only supports diabetes control but also improves survival for patients with lung SqCLC.
Correction: Erlichman et al. Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes. Cancers 2022, 14, 1042
Authors: Erlichman Nofar , Baram Tamir , Meshel Tsipi , Morein Dina , Da’adoosh Benny , Ben-Baruch Adit
Published: May 2022

The authors apologize for several typos/technical inaccuracies in the original article [...]
Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer
Authors: Yamashita Nami , Fushimi Atsushi , Morimoto Yoshihiro , Bhattacharya Atrayee , Hagiwara Masayuki , Yamamoto Masaaki , Hata Tsuyoshi , Shapiro Geoffrey I. , Long Mark D. , Liu Song , Kufe Donald
Published: May 2022

The MUC1-C apical transmembrane protein is activated in the acute response of epithelial cells to inflammation. However, chronic MUC1-C activation promotes cancer progression, emphasizing the importance of MUC1-C as a target for treatment. We report here that MUC1-C is necessary for intrinsic expression of the RIG-I, MDA5 and cGAS cytosolic nucleotide pattern recognition receptors (PRRs) and the cGAS-stimulator of IFN genes (STING) in triple-negative breast cancer (TNBC) cells. Consistent with inducing the PRR/STING axis, MUC1-C drives chronic IFN-β production and activation of the type I interferon (IFN) pathway. MUC1-C thereby induces the IFN-related DNA damage resistance gene signature (IRDS), which includes ISG15, in linking chronic inflammation with DNA damage resistance. Targeting MUC1-C in TNBC cells treated with carboplatin or the PARP inhibitor olaparib further demonstrated that MUC1-C is necessary for expression of PRRs, STING and ISG15 and for intrinsic DNA damage resistance. Of translational relevance, MUC1 significantly associates with upregulation of STING and ISG15 in TNBC tumors and is a target for treatment with CAR T cells, antibody–drug conjugates (ADCs) and direct inhibitors that are under preclinical and clinical development.
Searching for SARS-CoV-2 in Cancer Tissues: Results of an Extensive Methodologic Approach based on ACE2 and Furin Expression
Authors: Ricardo Sara , Canão Pedro , Martins Diana , Magalhães Ana C. , Pereira Marina , Ribeiro-Junior Ulysses , de Mello Evandro Sobroza , Alves Venâncio A. , Pinto Regina , Leitão Dina , Alves Georgina , Oliveira Rute , Wilton Joana , Costelha Susete , Meireles Diana , Cabanes Didier , David Leonor , Schmitt Fernando
Published: May 2022

SARS-CoV-2 pandemics have been massively characterized on a global scale by the rapid generation of in-depth genomic information. The main entry gate of SARS-CoV-2 in human cells is the angiotensin-converting enzyme 2 (ACE2) receptor. The expression of this protein has been reported in several human tissues, suggesting a correlation between SARS-CoV-2 organotropism and ACE2 distribution. In this study, we selected (a series of) 90 patients who were submitted to surgery for tumor removal between the beginning of the SARS-CoV-2 pandemic and the closure of operating rooms (by the end of March 2020) in two different countries—Portugal and Brazil. We evaluated the expressions of ACE2 and furin (another important factor for virus internalization) in colon (n = 60), gastric (n = 19), and thyroid (n = 11) carcinomas. In a subseries of cases with PCR results for SARS-CoV-2 detection in the peri-operatory window (n = 18), we performed different methodological approaches for viral detections in patient tumor samples. Our results show that colon and gastric carcinomas display favorable microenvironments to SARS-CoV-2 tropism, presenting high expression levels of ACE2 and furin. From the subseries of 18 cases, 11 tested positive via PCR detection performed in tumor blocks; however, a direct association between the ACE2 expression and SARS-CoV-2 infection was not demonstrated in cancer cells using histology-based techniques, such as immunohistochemistry or in situ hybridization. This study raises the possibility of ACE2-mediated viral tropism in cancer tissues to be clarified in future studies.
Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity
Authors: Gubič Špela , Hendrickx Louise , Shi Xiaoyi , Toplak Žan , Možina Štefan , Theemsche Kenny , Pinheiro-Junior Ernesto , Peigneur Steve , Labro Alain , Pardo Luis , Tytgat Jan , Tomašič Tihomir , Mašič Lucija
Published: May 2022

The voltage-gated potassium channel KV1.3 has been recognized as a tumor marker and represents a promising new target for the discovery of new anticancer drugs. We designed a novel structural class of KV1.3 inhibitors through structural optimization of benzamide-based hit compounds and structure-activity relationship studies. The potency and selectivity of the new KV1.3 inhibitors were investigated using whole-cell patch- and voltage-clamp experiments. 2D and 3D cell models were used to determine antiproliferative activity. Structural optimization resulted in the most potent and selective KV1.3 inhibitor 44 in the series with an IC50 value of 470 nM in oocytes and 950 nM in Ltk− cells. KV1.3 inhibitor 4 induced significant apoptosis in Colo-357 spheroids, while 14, 37, 43, and 44 significantly inhibited Panc-1 proliferation.
Development and Evaluation of a Multimodal Supportive Intervention for Promoting Physical Function in Older Patients with Cancer
Authors: Shehu Eni , Roggendorf Sigrid , Golla André , Koenig Antonia , Stangl Gabriele I. , Diestelhorst Andrea , Medenwald Daniel , Vordermark Dirk , Steckelberg Anke , Schmidt Heike
Published: May 2022

Physical function (PF) in older patients with cancer may decline during and after oncologic therapy. This study aimed to develop and pilot test an individually tailored unsupervised physical activity (PA) program and dietary recommendations to promote PF in older patients with cancer. Following development and pretest, the intervention was pilot tested to explore feasibility, acceptance, adherence and potential benefit. Patients ≥60 years, with heterogeneous cancer diagnoses, starting outpatient radiotherapy were randomized in two study arms: paper-based vs. video-based instructions. Based on assessments of PF, PA, nutrition, cognition, mental health, social support, HRQOL and personal goals, participants received individual recommendations for PA and nutrition. After 12 weeks of intervention (T1), reassessments were performed. The postal 4-week follow-up questionnaire included PA, nutrition and HRQOL. Participants (n = 24, 14 female, mean age 70 ± 7 years) showed comparable characteristics in both study arms. The majority rated the program as helpful. Facilitators and barriers to PA adherence were collected. Both modes of instructions were appreciated equally. PF (EORTC QLQ-C30) declined slightly (not clinically relevant >10 pts.) at group level T0: 76 ± 16, T1: 68 ± 21, T2: 69 ± 24. The intervention was feasible, well accepted, showing potential benefit for the maintenance of PF during outpatient radiotherapy, and should be further tested in a larger sample.
The Involvement of Human Papilloma Virus in Gastrointestinal Cancers
Authors: Baj Jacek , Forma Alicja , Dudek Iga , Chilimoniuk Zuzanna , Dobosz Maciej , Dobrzyński Michał , Teresiński Grzegorz , Buszewicz Grzegorz , Flieger Jolanta , Portincasa Piero
Published: May 2022

Human Papilloma Virus (HPV) is one of the most common sexually transmitted infections worldwide. HPV infection has a strong relationship with the onset of cervix uteri, vagina, penis, anus, and oropharynx, but also tonsils and tongue cancers. Some epidemiological data indicate that except for gynecologic cancers, HPV infection can be one of the risk factors associated with a greater risk of induction and progression of gastrointestinal cancers. Data, however, remain contradictory and definite conclusions cannot be drawn, so far. The following review aims to organize recent evidence and summarize the current state of knowledge regarding the association between HPV infection and gastrointestinal tumors primarily focusing on esophageal, liver, gastric, colorectal, and anal cancers.
Early Steps of Resistance to Targeted Therapies in Non-Small-Cell Lung Cancer
Authors: Delahaye Celia , Figarol Sarah , Pradines Anne , Favre Gilles , Mazieres Julien , Calvayrac Olivier
Published: May 2022

Lung cancer is the leading cause of cancer-related deaths among men and women worldwide. Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are effective therapies for advanced non-small-cell lung cancer (NSCLC) patients harbouring EGFR-activating mutations, but are not curative due to the inevitable emergence of resistances. Recent in vitro studies suggest that resistance to EGFR-TKI may arise from a small population of drug-tolerant persister cells (DTP) through non-genetic reprogramming, by entering a reversible slow-to-non-proliferative state, before developing genetically derived resistances. Deciphering the molecular mechanisms governing the dynamics of the drug-tolerant state is therefore a priority to provide sustainable therapeutic solutions for patients. An increasing number of molecular mechanisms underlying DTP survival are being described, such as chromatin and epigenetic remodelling, the reactivation of anti-apoptotic/survival pathways, metabolic reprogramming, and interactions with their micro-environment. Here, we review and discuss the existing proposed mechanisms involved in the DTP state. We describe their biological features, molecular mechanisms of tolerance, and the therapeutic strategies that are tested to target the DTP.
Real World Evaluation of the Prosigna/PAM50 Test in a Node-Negative Postmenopausal Swedish Population: A Multicenter Study
Authors: Kjällquist Una , Acs Balazs , Margolin Sara , Karlsson Emelie , Kessler Luisa Edman , Garcia Hernandez Scarlett , Ekholm Maria , Lundgren Christine , Olsson Erik , Lindman Henrik , Foukakis Theodoros , Matikas Alexios , Hartman Johan
Published: May 2022

Molecular signatures to guide decisions for adjuvant chemotherapy are recommended in early ER-positive, HER2-negative breast cancer. The objective of this study was to assess what impact gene-expression-based risk testing has had following its recommendation by Swedish national guidelines. Postmenopausal women with ER-positive, HER2-negative and node negative breast cancer at intermediate clinical risk and eligible for chemotherapy were identified retrospectively from five Swedish hospitals. Tumor characteristics, results from Prosigna® test and final treatment decision were available for all patients. Treatment recommendations were compared with the last version of regional guidelines before the introduction of routine risk signature testing. Among the 360 included patients, 41% (n = 148) had a change in decision for adjuvant treatment based on Prosigna® test result. Out of the patients with clinical indication for adjuvant chemotherapy, 52% (n = 118) could avoid treatment based on results from Prosigna® test. On the contrary, 23% (n = 30) of the patients with no indication were escalated to receive adjuvant chemotherapy after testing. Ki67 could not distinguish between the Prosigna® risk groups or intrinsic subtypes and did not significantly differ between patients in which decision for adjuvant therapy was changed based on the test results. In conclusion, we report the first real-world data from implementation of gene-expression-based risk assessment in a Swedish context, which may facilitate the optimization of future versions of the national guidelines.
Lindqvist versus Keggin-Type Polyoxometalates as Catalysts for Effective Desulfurization of Fuels
Authors: Fernandes Simone , Mirante Fátima , Castro Baltazar de , Granadeiro Carlos M. , Balula Salete S.
Published: May 2022

A correlation between polyoxotungstate structures and their catalytic performance for oxidative desulfurization processes was investigated. Bridged lanthanopolyoxometalates that incorporate identical metallic centers with Keggin- Eu[PW11O39]11− and Lindqvist-type [Eu(W5O18)2]9− structures were used as catalysts for the oxidation of the most representative refractory sulfur compounds. Both compounds were able to desulfurize a multicomponent model diesel under sustainable conditions, i.e., using ionic liquid as an extraction solvent and hydrogen peroxide as an oxidant. However, the Lindqvist catalyst appeared to achieve complete desulfurization faster than the Keggin catalyst while using a lesser amount of catalyst and oxidant. Furthermore, the reusable capacity of the Lindqvist-type [Eu(W5O18)2]9− was confirmed for consecutive oxidative desulfurization processes. The contribution of the lanthanide metallic center for the catalytic performance of these compounds was investigated by studying the analogous [TB(W5O18)2]9− compound. Identical desulfurization efficiency was obtained, even reusing this catalyst in consecutive reaction cycles. These results indicate that the active catalytic center of these compounds is probably related to the octahedral tungsten centers. However, a higher number of tungsten centers in the polyoxometalate structure did not result in higher catalytic activity.
Radiosensitization by the Selective Pan-FGFR Inhibitor LY2874455
Authors: Darwis Narisa Dewi Maulany , Horigome Eisuke , Li Shan , Adachi Akiko , Oike Takahiro , Shibata Atsushi , Hirota Yuka , Ohno Tatsuya
Published: May 2022

Ionizing radiation activates cytoprotective pathways in cancer cells. Fibroblast growth factor receptor (FGFR) is a key player in these pathways. Thus, FGFR signaling is a potential target to induce radiosensitization. LY2874455 is an orally administrable selective pan-FGFR inhibitor. However, the radiosensitizing effects of LY2874455 remain unclear. In this study, we addressed this issue by using radioresistant human cancer cell lines H1703 (FGFR1 mutant), A549 (FGFR1–4 wild-type), and H1299 (FGFR1–4 wild-type). At an X-ray dose corresponding to 50%-clonogenic survival as the endpoint, 100 nM LY2874455 increased the sensitivity of H1703, A549, and H1299 cells by 31%, 62%, and 53%, respectively. The combination of X-rays and LY2874455 led to a marked induction of mitotic catastrophe, a hallmark of radiation-induced cell death. Furthermore, combination treatment suppressed the growth of A549 xenografts to a significantly greater extent than either X-rays or the drug alone without noticeable toxicity. This is the first report to show the radiosensitizing effect of a selective pan-FGFR inhibitor. These data suggest the potential efficacy of LY2874455 as a radiosensitizer, warranting clinical validation.
Menke–Hennekam Syndrome: A Literature Review and a New Case Report
Authors: Sima Aurora , Smădeanu Roxana Elena , Simionescu Anca Angela , Nedelea Florina , Vlad Andreea-Maria , Becheanu Cristina
Published: May 2022

Background: Menke–Hennekam syndrome (MHS) is a rare and recently described syndrome consecutive to the variants in exon 30 or 31 in CREBBP (CREB-binding protein gene). The CREB-binding protein (CREBBP) and EP300 genes are two commonly expressed genes whose products possess acetyltransferase activity for histones and various other proteins. Mutations that affect these two genes are known to cause Rubinstein–Taybi syndrome (RTS); however, with the application of whole exome sequencing (WES) there were reports of variants that affect specific regions of exon 30 or 31 of these two genes but without the specific phenotype of RTS. Material and Methods: A review of the available literature was conducted, aimed at underscoring the difficulties in diagnosing MHS based on phenotype particularities. Results: Five applicable studies were identified by searching PubMed, Web of Science, and Scopus databases for publications up to November 2021 using the key terms “Menke–Hennekam syndrome” and “CREBBP”. Conclusions: In this paper, we present a new case and highlight the importance of exome sequencing to identify different mutations of exons 30 and 31 of the CREBBP gene involved in MHS, and we make formal recommendations based on our literature review.
Palliative Care for Childhood Cancer
Authors: Michiels Erna M.
Published: May 2022

Cure rates for children with cancer are improving, but often at the cost of quality of life during treatment [...]
Rice Lesion Mimic Gene Cloning and Association Analysis for Disease Resistance
Authors: Zhang Anpeng , Jiang Hongzhen , Chu Huangwei , Cao Liming , Chen Jingguang
Published: May 2022

Lesion mimic mutants refer to a class of mutants that naturally form necrotic lesions similar to allergic reactions on leaves in the absence of significant stress or damage and without being harmed by pathogens. Mutations in most lesion mimic genes, such as OsACL-A2 and OsSCYL2, can enhance mutants’ resistance to pathogens. Lesion mimic mutants are ideal materials for studying programmed cell death (PCD) and plant defense mechanisms. Studying the genes responsible for the rice disease-like phenotype is of great significance for understanding the disease resistance mechanism of rice. In this paper, the nomenclature, occurrence mechanism, genetic characteristics, regulatory pathways, and the research progress on the cloning and disease resistance of rice lesion mimic mutant genes were reviewed, in order to further analyze the various lesion mimic mutants of rice. The mechanism lays a theoretical foundation and provides a reference for rice breeding.
Atmospheric Corrosion of Silver and Silver Nanoparticles
Authors: Keast Vicki J.
Published: May 2022

Even though it is a noble metal, silver will corrode in ambient atmospheres, predominantly by reacting with sulfur-containing gases such as hydrogen sulfide (H2S) and carbonyl sulfide (OCS) to form the silver sulfide (Ag2S) acanthite. Other aspects of the environment, such as relative humidity and the presence of oxidizing species, also play a critical role. With the emergence of silver nanoparticles for a range of technological and medical applications, there has been a revival of interest in the corrosion behavior of this important metal. This article reviews the current understanding of the atmospheric corrosion of silver in both the bulk and nanoparticle forms. Gaps in our current understanding and areas for future investigation are identified.
Documenting the Evolution of a Southern California Coastal Lagoon during the Late Holocene
Authors: Dickson Sarah , Carlin Joseph , Bonuso Nicole , Kirby Matthew E.
Published: May 2022

Coastal wetlands are declining globally, and although wetland restoration looks to offset these losses, its success relies on anticipating environmental response to external forces. The purpose of this study is to investigate the sedimentological record of Los Peñasquitos Lagoon to determine the processes that drive environmental transitions in a Southern California coastal wetland. For this project, we analyze three sediment cores from the wetland for grain size, total organic matter, and shell assemblages to reconstruct environmental change over the past ~4000 years. From the results, we find that the lagoon was initially an open embayment that persisted for >2000 years; however, at ~1000 cal yrs BP, a short-lived wet climatic period triggered a fluvial deltaic progradation at the head of the lagoon. As the wet period ended and drier conditions returned, the delta began to retreat, and the lagoon infilled as the estuarine mouth bar was permanently established. The permanent establishment of the mouth bar resulted in a transition to a marsh-dominated environment throughout the wetland. Ultimately, these environmental transitions were driven by climate variability, although evidence of human impacts was observed more recently in the record. Therefore, future restoration efforts must consider both natural climatic variability and anthropogenic influences if they intend to sustain coastal wetlands.
Influence of Prevailing Wind Direction on Sapping Quantity of Rammed Earth Great Wall of the Ming Dynasty
Authors: Su Na , Yang Bo , Chen Wenwu , Xu Linrong , Li Yongwei
Published: May 2022

Sapping caused by prevailing wind erosion is one of the most significant factors in the deterioration of earthen sites located in Datong County, Qinghai Province, China. Long-term effects of wind may cause surface erosion, or even serious damage to the Great Wall of Ming Dynasty. Difference of sapping quantity should be attributed to variability of the prevailing wind directions. To better understand the effects of wind direction on erosion, meteorological data in the study area for fifty-two years (from 1961 to 2013) were collected and statistically analyzed. Sapping quantity of earthen structure was measured by field investigation on the Wall along the ridge whose azimuth ranges from 95°–244° and mainly concentrated in 140°–210°. Results showing obvious difference of sapping quantity could be observed at both sides of the Wall under the prevailing wind directions (ESE, SE and SSE). Further, the Wall was divided into small segments with a length of 20 m for comparison and maximum sapping quantity could be found at the Wall whose azimuth is at an angle of 30° to the prevailing wind. The aim of this study is to provide reference for the deterioration of the Wall under long-term wind pressure, and provide a targeted conservation method for earthen structure.
Effect of Optical Properties of Lithium Disilicate Glass Ceramics and Light-Curing Protocols on the Curing Performance of Resin Cement
Authors: Meng Kejing , Wang Lu , Wang Jintao , Yan Zhuoqun , Zhao Bin , Li Bing
Published: May 2022

This study aimed to investigate the effects of optical properties of lithium disilicate glass ceramics and the light-curing protocols (LCP) on the curing performance of light-cured resin cement. Lithium disilicate glass-ceramics with different optical properties were sectioned to produce ceramic specimens of 0.8 mm thickness. Irradiance through the ceramic specimens was measured by a radiometer. Light transmittance of ceramics was assessed using a UV/Vis spectrophotometer. The light-cured resin cement was injected into a Teflon mold and ceramics with different optical properties were placed on it, cured under different LCPs, and the degree of conversion (DC) and Vickers microhardness of the resin cement were separately measured by Micro-ATR/FTIR spectrometry and the microhardness tester. The shade (p < 0.001) and transparency (p < 0.001) of ceramics affect the irradiance of the light-curing unit. The transparency (p < 0.001) of the ceramic and light-curing protocols (p < 0.001) affect the DC and microhardness of resin cements. When the thickness of the ceramic is 0.8 mm, the light transmittance of the ceramic and the curing performance of the resin cement increase with the increase of the transparency of the ceramic. An appropriate increase in irradiance and exposure time can optimize the curing performance of resin cement. These factors should be taken into account by the clinician when designing the bonding solution for porcelain veneers.
Structural, Morphologic, and Ferroelectric Properties of PZT Films Deposited through Layer-by-Layer Reactive DC Magnetron Sputtering
Authors: Beklešovas Benas , Iljinas Aleksandras , Stankus Vytautas , Čyvienė Jurgita , Andrulevičius Mindaugas , Ivanov Maksim , Banys Jūras
Published: May 2022

Lead zirconate titanate (PZT) is a widely used material with applications ranging from piezoelectric sensors to developing non-volatile memory devices. Pb(ZrxTi1−x)O3 films were deposited by DC reactive magnetron sputtering at a temperature range of (500–600) °C. X-ray diffraction (XRD) indicated the perovskite phase formation in samples synthesized at 550 °C, which agrees with Raman data analysis. Scanning electron microscopy (SEM) measurements supplemented XRD data and showed the formation of dense PZT microstructures. Further X-ray photoelectron spectroscopy (XPS) analysis confirmed that the Zr/Ti ratio corresponds to the Pb(Zr0.58Ti0.42)O3 content. Dielectric measurement of the same sample indicated dielectric permittivity to be around 150 at room temperature, possibly due to the defects in the structure. P-E measurements show ferroelectric behavior at a temperature range of (50–180) °C. It was found that the remnant polarization increased with temperature, and at the same time, coercive field values decreased. Such behavior can be attributed to energetically deep defects.
Control of Endogenous Phosphorus Release at the Sediment–Water Interface by Lanthanum-Modified Fly Ash
Authors: Pan Ying , Liu Gang , Chai Beibei , Lei Xiaohui , He Lixin , Cheng Shuailong , Wang Yijie , Chen Wenlong , Li Simin , Chen Liang , Chen Bin
Published: May 2022

This study optimizes the modification and granulation of fly ash to make it more stable at the sediment–water interface. Through laboratory simulations, the modified fly ash pellets were optimally granulated to cover the sediment–water interface, and its control effect and mechanism were evaluated. The results showed that the phosphorus adsorption effect of lanthanum-modified fly ash was 34% and 40% higher compared with those of acid-modified and alkali-modified fly ash, respectively, with the phosphorus adsorption effect reaching 85%. The best dosing ratio was about 0.3 g/L. Adsorption was affected by pH and was more effective under weak alkalinity, close to the Langmuir adsorption model, which was consistent with the unimolecular layer adsorption characteristics and the presence of chemisorption and physical adsorption. The saturation adsorption amount of phosphate by lanthanum-modified fly ash was 8.89 mg/g. The optimized granulation conditions for lanthanum-modified fly ash pellets were a fly ash/montmorillonite ratio of 7:3, a roasting temperature of 900 °C, a roasting time of 4 h, and a particle size of 3 mm. After 20 days, the orthophosphate removal rate was more than 60% higher than that of the control group, with a total phosphorus removal rate of 43%. After covering for 60 days, active phosphorus in the surface layer of the sediment was gradually transformed into a stable phosphorus form, with calcium phosphorus accounting for 70% of the total inorganic phosphorus. The ability of the sediment to release phosphorus to the overlying water body was also significantly weakened. Meanwhile, the total phosphorus removal rate in the overlying water at the sediment–water interface reached more than 40%, and orthophosphate removal reached more than 60%, indicating an obvious phosphorus control effect. Transmission electron microscopy analysis showed that lanthanum was present at locations enriched with elemental phosphorus and was adsorbed onto the material surface. Therefore, lanthanum-modified fly ash pellets are a promising in situ phosphorus control agent with good endogenous phosphorus pollution control abilities in eutrophic water bodies.
The Enhanced Swelling Resistance of W/Cu Nanocomposites by Vacancy-Type Defects Self-Recovery
Authors: Chen Huaican , Hai Yang , Zhan Xiaozhi , Xu Juping , Cao Xingzhong , Zhu Tao , Yin Wen
Published: May 2022

In this study, the swelling resistance of W/Cu nanocomposites is investigated after helium irradiation at RT and 400 °C. The results show that W/Cu nanocomposites with interface structure present better resistance to helium swelling as compared with W monolayer. The PAS results reveal that the unique interfacial structure of W/Cu nanocomposites effectively improves the recovery of vacancy-type defects under He+ irradiation, which results in good resistance to irradiation swelling. This result shows that introducing interface structure can effectively enhance the swelling resistance of materials and sheds light on the design of radiation-tolerant materials for advanced nuclear reactor applications.
A Review of Coastal Anthropogenic Impacts on Mytilid Mussel Beds: Effects on Mussels and Their Associated Assemblages
Authors: Sampaio Leandro , Moreira Juan , Rubal Marcos , Guerrero-Meseguer Laura , Veiga Puri
Published: May 2022

Mussel beds are an important habitat in many coastal systems, harboring a high diversity of biota. They are threatened by anthropogenic impacts that affect mussels and their associated assemblages. Pollution, harvesting, trampling, dredging and trawling are major threats faced by these communities. Most of the studies on the effects of such impacts on the mussel beds overlook the associated fauna. Since mussels are very resilient, especially to pollution, the associated fauna can provide a better footprint of the impacts’ effects. In this review, we looked into the main remarks regarding the effects of anthropogenic impacts in mussel bed communities. Organic pollution was the best studied impact and the Atlantic region was the best studied zone. Low values of abundance, biomass, diversity, evenness and species richness were reported for all categories of impacts, with some studies describing declines in at least three of these descriptors. Among the associated fauna, some tolerant species benefited from the impacts, particularly organic enrichment, and became more abundant, but sensitive species suffered considerable declines in density, mainly in dredging and trawling impacts. Therefore, fauna associated with mussel beds is a suitable indicator of anthropogenic disturbances.
Fracture Related Infections and Their Risk Factors for Treatment Failure—A Major Trauma Centre Perspective
Authors: Lu Victor , Zhang James , Patel Ravi , Zhou Andrew Kailin , Thahir Azeem , Krkovic Matija
Published: May 2022

Fracture related infections (FRI) are debilitating and costly complications of musculoskeletal trauma surgery that can result in permanent functional loss or amputation. Surgical treatment can be unsuccessful, and it is necessary to determine the predictive variables associated with FRI treatment failure, allowing one to optimise them prior to treatment and identify patients at higher risk. The clinical database at a major trauma centre was retrospectively reviewed between January 2015 and January 2021. FRI treatment failure was defined by infection recurrence or amputation. A univariable logistic regression analysis was performed, followed by a multivariable regression analysis for significant outcomes between groups on univariable analysis, to determine risk factors for treatment failure. In total, 102 patients were identified with a FRI (35 open, 67 closed fractures). FRI treatment failure occurred in 24 patients (23.5%). Risk factors determined by our multivariate logistic regression model were obesity (OR 2.522; 95% CI, 0.259–4.816; p = 0.006), Gustilo Anderson type 3c (OR 4.683; 95% CI, 2.037–9.784; p = 0.004), and implant retention (OR 2.818; 95% CI, 1.588–7.928; p = 0.041). Given that FRI treatment in 24 patients (23.5%) ended up in failure, future management need to take into account the predictive variables analysed in this study, redirect efforts to improve management and incorporate adjuvant technologies for patients at higher risk of failure, and implement a multidisciplinary team approach to optimise risk factors such as diabetes and obesity.
Surgical Management of Spinal Tuberculosis—The Past, Present, and Future
Authors: Ruparel Sameer , Tanaka Masato , Mehta Rahul , Yamauchi Taro , Oda Yoshiaki , Sonawane Sumeet , Chaddha Ram
Published: May 2022

Tuberculosis is endemic in many parts of the world. With increasing immigration, we can state that it is prevalent throughout the globe. Tuberculosis of the spine is the most common form of bone and joint tuberculosis; the principles of treatment are different; biology, mechanics, and neurology are affected. Management strategies have changed significantly over the years, from watchful observations to aggressive debridement, to selective surgical indications based on well-formed principles. This has been possible due to the development of various diagnostic tests for early detection of the disease, effective anti-tubercular therapy, and associated research, which have revolutionized treatment. This picture is rapidly changing with the advent of minimally invasive spine surgery and its application in treating spinal infections. This review article focuses on the past, present, and future principles of surgical management of tuberculosis of the spine.
Efficient Perineural Invasion Detection of Histopathological Images Using U-Net
Authors: Park Youngjae , Park Jinhee , Jang Gil-Jin
Published: May 2022

Perineural invasion (PNI), a sign of poor diagnosis and tumor metastasis, is common in a variety of malignant tumors. The infiltrating patterns and morphologies of tumors vary by organ and histological diversity, making PNI detection difficult in biopsy, which must be performed manually by pathologists. As the diameters of PNI nerves are measured on a millimeter scale, the PNI region is extremely small compared to the whole pathological image. In this study, an efficient deep learning-based method is proposed for detecting PNI regions in multiple types of cancers using only PNI annotations without detailed segmentation maps for each nerve and tumor cells obtained by pathologists. The key idea of the proposed method is to train the adopted deep learning model, U-Net, to capture the boundary regions where two features coexist. A boundary dilation method and a loss combination technique are proposed to improve the detection performance of PNI without requiring full segmentation maps. Experiments were conducted with various combinations of boundary dilation widths and loss functions. It is confirmed that the proposed method effectively improves PNI detection performance from 0.188 to 0.275. Additional experiments were also performed on normal nerve detection to validate the applicability of the proposed method to the general boundary detection tasks. The experimental results demonstrate that the proposed method is also effective for general tasks, and it improved nerve detection performance from 0.511 to 0.693.
Controllable and Scalable Fabrication of Superhydrophobic Hierarchical Structures for Water Energy Harvesting
Authors: Guo Meiling , Wang Cheng , Yang Zhenchao , Xu Zhentao , Yang Mingshun , Zhao Pengkang , Zhou Yan , Li Pengyang , Wang Quandai , Li Yan
Published: May 2022

We report a controllable and scalable fabrication approach for the superhydrophobic hierarchical structures and demonstrate the excellent ability to harvest water energy when applied to water-solid contact triboelectric nanogenerator (TENG). A strategy combined with multiple photolithography and micromolding process was developed to accurately regulate the diameters and the center distances of the two-level micropillars. A variety of hierarchical structures were successfully fabricated and presented the advantages of structure control, large scale, high accuracy, and high consistency. The hydrophobic property characterizations were conducted, and the results indicated that the hierarchical structures showed a larger contact angle than the single-level structures and achieved superhydrophobicity. Then the hierarchical structures were applied to water-TENGs with flowing water continuously dripping on, and the effect of the structure parameter on the triboelectric output was analyzed. The hierarchical structures exhibited a superior ability to harvest water energy than the flat film and the single-level structures due to the enhanced friction area and superhydrophobic property. At a flowing velocity of 8 mL/s, the hierarchical structure generated the output voltage of approximately 34 V and the short-circuit current of around 5 μA. The water-TENG device exhibited a power density peak of 7.56 μW/cm2 with a resistive load of 16.6 MΩ at a flowing velocity of 10 mL/s. These findings shed light on the potential applications of the hierarchical structures-based water-TENGs to water energy harvesting and self-powered sensor devices.