bluuebunny/crossref_metadata_2025 huggingface dataset:
Accrualls e risco sistemático nas empresas brasileiras
Authors: Oliveira Júnior José Luciano de , Nossa Valcemiro , Nossa Silvania Neris , Oliveira Edvan Soares de
Published: January 2023

Objetivo: Investigar se o risco sistemático das empresas listadas na Bolsa de valores brasileira (B3) é afetado pela qualidade das informações contábeis. Adicionalmente, verificou-se se o risco sistemático foi afetado de forma diferente após a obrigatoriedade da adoção das IFRS no Brasil.
Metodologia: A amostra compreendeu todas as empresas com observações listadas na bolsa de valores brasileira (B3) do período de 2005 a 2021. Foi realizada pesquisa empírica com análise descritiva e enfoque quantitativo. Os dados foram estimados em painel com efeitos fixo. Foram utilizadas como medidas de qualidade da informação contábil o valor total dos accruals de Dechow e Dichev (2002) e de Jones (1991). Já as medidas de risco sistemático foram estimadas por meio dos modelos de mercado e de três fatores de Fama e French (1993).
Resultados: De maneira geral, empresas que possuem informações contábeis de maior qualidade são capazes de reduzir problemas de assimetria informacional, que aumentam o risco sistemático, dessa maneira, ter maior qualidade nessas informações reduz o risco perante o investidor.
Contribuições do Estudo: Os resultados desta pesquisa trazem contribuições práticas para o mercado e investidores, que podem se sentir mais seguros pela clareza e confiança na informação. Inclusive, com a adoção das IFRS no Brasil, a principal conclusão é que ela de fato contribui para que qualidade da informação se converta em menores riscos.
Identification of bread wheat genotypes (Triticum aestivum L.) with tolerance to drought conditions at the central coast of Peru
Authors: Gomez-Pando L. , Dood Ian , Zamudio Ayala Diego , Deza Montoya Denisse , Eguiluz de la Barra Ana
Published: January 2023

Wheat is sown mostly in Peru, in areas above 3000 m altitude, under rainfed conditions and frequent drought problems during the crop cycle. It is a cereal used as a staple food by the families of small-scale farmers who are dedicated to their cultivation, which is why it is necessary to develop varieties with drought tolerance. This investigation had as objectives (1) to determine the yield potential of wheat genotypes under drought stress conditions, (2) to determine the susceptibility indices and drought tolerance, and (3) to identify drought tolerant genotypes. Nine genotypes introduced from CIMMYT and the commercial variety “Centenario” wheat flour (Triticum aestivum L.) were studied in an environment with complete irrigation during the life cycle and another environment with terminal drought stress or deficit irrigation applied in the boot phase (Z4.0). A Random Complete Blocks design was used with three repetitions. Agronomic characteristics, quality evaluations were carried out following the established protocols for each characteristic evaluated and the stress tolerance indices (STI), mean productivity (MP), geometric mean productivity (GMP), tolerance index (TOL), and stress susceptibility index (SSI), were determined. The reduction in the grain yield varied from 17.95 % to 33.27 % mainly due to drought. The SSI ranged from 0.65 (G-3) to 1.21 (G-6 y G-9), meanwhile the TOL ranged from 1 316.8 (G-3) to 3 142.68 (G-7). The MP, STI and GMP indexes allowed the identification of genotypes with the greatest tolerance to irrigation and stress conditions of the 5 genotypes: G- 1, G-2, G-7, G-8 and G- 10. These results are important for developing new varieties that adapt to drought conditions and to face climate change in the Andean region.
Chiral Inversion of Pharmaceutical Drugs - Mini Review
Authors: Aboul-Enein Hassan Y. , Kannappan Valliappan , Kanthiah Selvakumar
Published: January 2023

2-Arylpropionic acid nonsteroidal anti-inflammatory drugs (NSAIDs) provide one of the most demonstrated pharmaceutical examples of chiral inversion. Chiral inversion depends on various factors (viz. biological-, solvent-, light-, temperature-induced, etc.) and the energy barrier associated with the stereogenic element present in the chiral molecule. The pharmacological properties of chiral drugs depend on the activity of one enantiomer or both the enantiomers targeting different biological targets. Consequently, chiral inversion can alter the biological activities of the pharmaceutical drug. Hence a better understanding of chiral inversion, factors facilitating such inversion, and the tools employed to determine chiral inversion are of great significance from a pharmacological and toxicological perspective.
Chromosome-level Genome Assembly and Sex-specific Differential Transcriptome
of the White-backed Planthopper, Sogatella furcifera
Authors: Zhang Chuan-Xi , Ye Yu-Xuan , Li Dan-Ting , Zhang Si-Yu , Shen Zhi-Cheng
Published: January 2023

Background:

The white-backed planthopper (WBPH), Sogatella furcifera, causes great
damage to many crops (mainly rice) by direct feeding or transmitting plant viruses. The previous genome
assembly was generated by second-generation sequencing technologies, with a contig N50 of
only 51.5 kb, and contained a lot of heterozygous sequences.

Methods:

We utilized third-generation sequencing technologies and Hi-C data to generate a highquality
chromosome-level assembly. We also provide a large amount of transcriptome data for fulllength
transcriptome analysis and gender differential expression analysis.

Results:

The final assembly comprised 56.38 Mb, with a contig N50 of 2.20 Mb and a scaffold N50 of
45.25 Mb. Fourteen autosomes and one X chromosome were identified. More than 99.5% of the assembled
bases located on the 15 chromosomes. 95.9% of the complete BUSCO Hemiptera genes were
detected in the final assembly and 16,880 genes were annotated. 722 genes were relatively highly expressed
in males, while 60 in the females.

Conclusion:

The integrated genome, definite sex chromosomes, comprehensive transcriptome profiles,
high efficiency of RNA interference and short life cycle substantially made WBPH an efficient
research object for functional genomics.
Multilevel Pharmacological Effects of Antipsychotics in Potential Glioblastoma
Treatment
Authors: Awuah Wireko Andrew , Alexiou Athanasios , Kalmanovich Jacob , Mehta Aashna , Huang Helen , Abdul-Rahman Toufik , Cheng  Ng Jyi , Yarlagadda Rohan , Kamanousa Karl , Kundu Mrinmoy , Nansubuga Esther Patience , Hasan Mohammad Mehedi , Lyndin Mykola , Isik Arda , Sikora Vladyslav
Published: January 2023

Glioblastoma Multiforme (GBM) is a debilitating type of brain cancer with a high mor-tality rate. Despite current treatment options such as surgery, radiotherapy, and the use of te-mozolomide and bevacizumab, it is considered incurable. Various methods, such as drug reposition-ing, have been used to increase the number of available treatments. Drug repositioning is the use of FDA-approved drugs to treat other diseases. This is possible because the drugs used for this purpose have polypharmacological effects. This means that these medications can bind to multiple targets, resulting in multiple mechanisms of action. Antipsychotics are one type of drug used to treat GBM. Antipsychotics are a broad class of drugs that can be further subdivided into typical and atypical classes. Typical antipsychotics include chlorpromazine, trifluoperazine, and pimozide. This class of antipsychotics was developed early on and primarily works on dopamine D2 receptors, though it can also work on others. Olanzapine and Quetiapine are examples of atypical antipsychotics, a cate-gory that was created later. These medications have a high affinity for serotonin receptors such as 5-HT2, but they can also act on dopamine and H1 receptors. Antipsychotic medications, in the case of GBM, also have other effects that can affect multiple pathways due to their polypharmacological effects. These include NF-B suppression, cyclin deregulation, and -catenin phosphorylation, among others. This review will delve deeper into the polypharmacological, the multiple effects of antipsy-chotics in the treatment of GBM, and an outlook for the field's future progression.
Traditional use, Phytochemistry and Pharmacological Properties of the Genus Onopordum
Authors: Mouffouk Chaima , Mouffouk Soumia , Mouffouk Sara , Haba Hamada
Published: January 2023

Background:

The genus Onopordum (Asteraceae), with about 40 species, is composed of perennials and spermatophyte plants, which are widely used in popular medicine for the treatment of several human diseases. Plants of this genus constitute an interesting source of bioactive molecules with a wide range of pharmacological applications.

Objective:

In this context, the current study describes a critical review of traditional uses, phytochemistry, and pharmacological effects of the genus Onopordum in order to establish a valuable database for future ethnopharmacological surveys on this genus.

Methods:

For this, all bibliographic data covering the period of 1970 to 2022 were collected and analyzed.

Results:

Only 19 species from the genus Onopordum were studied. They are traditionally used to treat gastric, renal, respiratory, urinary, and gynecological diseases and in the food industry for cheese production. Indeed, it was found that Onopordum species are rich in flavonoids, phenolic compounds, terpenoids, alkaloids, tannins, and steroids. These plants exhibit several interesting biological activities including: antioxidant, antimicrobial, antiproliferative, apoptotic, cytotoxic, antitumor, anticholinergic, larvicidal, analgesic and antipyretic, hypotensive, antiepileptic, and anticonvulsant activities. Furthermore, their hemostatic, anti-inflammatory, and moisturizing properties, increase their usefulness in the cosmetic field.

Conclusion:

According to the present study, Onoporadum species constitute an important natural source of secondary metabolites with potential therapeutic, cosmetic, and nutritional applications. However, the focus has been only on 19 species and the publications were not very explanatory, Therefore, in-depth pharmacological and phytochemical studies are needed to fully exploit the therapeutic potential and the chemical composition of Onopordum species.
Experimental Studies and Comparative Analyses on Apparent
Viscosity of Solid Particle, Droplet, and Bubble Suspensions
Authors: Pang Mingjun , Zhang Shihuan , Niu Ruipeng
Published: January 2023

Background:

Suspensions can be frequently seen in natural, industrial, and
agricultural processes. The addition of dispersed phases (such as solid particles, droplets,
and bubbles) greatly affects the rheological properties of matrix liquid. Therefore, it
is very important to understand the rheological properties of particle suspensions for
optimizing production processes and improving process efficiencies.

Objective:

To explore qualitatively the physical law and internal mechanism of the apparent
viscosity of suspensions formed by a Newtonian liquid containing solid particles,
droplets, and bubbles, respectively.

Methods:

The apparent viscosity of suspensions was measured and analyzed using a
rotary rheometer (MCR302), and the evolution of particles was recorded using a highspeed
camera (Revealer 2F01M).

Results:

When the deformation of deformable particles (such as bubbles or water droplets)
is slight (close to a sphere in shape), or the arrangement of rigid particles is disordered,
the relative viscosity of suspensions is greater than 1. When the deformation of
deformable particles is large (greatly deviating from a sphere in shape) or rigid particles
are arranged in order, the apparent viscosity of suspensions decreases and the relative
viscosity of suspensions containing deformable particles is less than 1.

Conclusion:

The apparent viscosity of suspensions is closely related to particle shape,
particle arrangement, and volume fraction. The higher volume fraction of particles significantly
influences the apparent viscosity of suspensions.
Silicon Prismanes: Calculation and Comparison of Heats of Formation
Authors: Zauer Elena A. , Ershov Alexander B.
Published: January 2023

Background:

The objects of this work are silicon prismanes - new highenergy
materials that can be used in various electronic, optoelectronic, thermoelectric,
and biological fields and compete with traditional chemical energy carriers. However,
only compounds with hexasilacubane and octasilacubane have been synthesized to
date. Synthesis of other silapismanes, and even more so polysilaprismanes, has not yet
been achieved. Therefore, both the “simplest” and the highest silaprismanes are studied
mainly theoretically, including by quantum chemistry methods.

Objective and Methods:

To expand information about the enthalpies of formation of
"simple" (n = 2) and multilayer (n = 3-7) silicon prismanes using semiempirical calculation
methods; bond lengths Si-Si and Si-H; compare them with the results of ab initio
calculations already available in the literature.

Results:

The geometry was optimized by semiempirical methods, the enthalpies of
formation, Si-Si and Si-H bond lengths, and the bond angles of the bilayer (m = 3-12)
and some multilayer (n = 3-8 and m = 3-9) silaprismanes were determined. Comparison
with the enthalpies of formation obtained using ab initio calculations shows that
the enthalpies of formation obtained by the MINDO/3 method (Modified Intermediate
Neglect of Differential Overlap, version 3) are closest to the results of ab initio calculations
of two-layer silicon prismanes; and for multilayers - by the AM1 method (Austin
Model 1). Large differences in the lengths of Si-H bonds determined ab initio and
semi-empirically by both methods are not observed. As for the Si-Si bonds, the results
of semi-empirical methods indicate the presence of the so-called auxetic effect in multilayer
silaprismanes.

Conclusion:

We believe that in the future, the calculations carried out in this work and
a comparative assessment of the enthalpies of formation obtained by calculation
methods will help to overcome the problems associated with the synthesis of silicon
prismanes.
Impact of Heavy Metals Toxicity on Children and Adults from Local Rice Varieties of Northern Nigeria
Authors:   Department of Chemistry, Faculty of Science, Federal University Dutse, Nigeria, Olaleye Abdul A. , Adubiaro Habibat O. , Dauda Aminu , Adamu Yahaya A.
Published: January 2023

The current study aimed to investigate the levels of heavy metals [cadmium (Cd), zinc (Zn), arsenic (As), lead (Pb), and mercury (Hg)] in local rice varieties named Jamila (JM), Santana (STN), Kwandala (KW), and Sipi (SP) collected from Danbatta town of Kano State, Northwestern Nigeria. The samples of local rice varieties were digested using HNO3 and HCl as digestion acids in a ratio of 2:1 (v/v). The digested samples were later analyzed for heavy metals using atomic absorption spectrophotometer. Moreover, the health risk assessment of heavy metals by the consumption of local rice varieties among local children and adults was also estimated based on estimated daily intake (EDI), target hazard quotient (THQ), hazard index (HI), and target cancer risk (TCR). The concentrations of Cd, Zn, and Pb dry weight basis observed in the range of 0.002- 0.06, 0.02-20.0, and 1.16-14.2mg/kg, respectively. Hg was detected only in SP rice variety with a concentration of 0.022 mg/kg. Whereas, As was detected in STN (0.086 mg/kg), KW (0.006 mg/kg), and SP (0.028 mg/kg). The resulting data showed that Cd, Zn, Hg, and As were within the maximum permissible limits set by regulatory bodies. The EDI values ranged from 1.21E-5 - 1.21E-1 and 5.0E-6 – 5.0E-2 for children (24 kg body weight) and adults (70 kg body weight), respectively. The data of the non-carcinogenic risk assessment indicated that the THQ values of Cd, Hg, and As were less than the maximum permissible limit of 1.00 for both children and adults. The HI data showed the potentially high possible health risk of the heavy metals by the consumption of the studied local rice varieties, with Pb being the major contributor. Similarly, resulting data of TCR for Cd and Pb showed high cancer risk upon the consumption of the studied local rice varieties over a long time.
Spectrophotometric Determination of Catecholamine Containing Drugs Using Calcon Dye
Authors:   Chemistry Depart ment, College of Education for Pure Science, Mosul University, Mosul, Iraq, Othman Ikram K. , Al-Sabha Theia’a N.
Published: January 2023

Calcon dye has been used for spectrophotometric determination of catecholamine-containing drugs, namely, adrenaline, methyldopa and dopamine in their pure forms and pharmaceutical formulations. The method is based on the oxidation of the above drugs with an excess of Nbromosuccinimide (NBS) in an acidic medium. The residual oxidizing agent bleaches the blackish-brown color of calcon measured at 510 nm. The decolorization of the dye is proportional to the residual amount of NBS, which is proportional to the concentration of the drug. Linear calibration graphs were obtained in the concentration range 0.5-16.0, 2.0-40.0 and 1.036.0 μgmL -1 with molar absorptivity values 1.10×104 , 3.2×103 and 4.3×103 Lmol-1 cm-1 for above drugs, respectively. The method is simple, sensitive, accurate, precise and free from excipients. The developed method was successfully applied to determine the drugs in their pharmaceutical formulations.
Determination of Diclofenac Diethylamine Levels in Emulgel Preparations Using NIR Spectroscopy Combined with Chemometrics
Authors:   Faculty of Pharmacy, University of Jember, Kalimantan Street 37 Jember, 68121, Indonesia, Wulandari Lestyo , Pratiwi Karima , Retnaningtyas Yuni
Published: January 2023

Diclofenac is an NSAID-class drug with activity as an analgesic and anti-inflammatory recommended for treating various acute and chronic pain conditions. One of the topical preparations of diclofenac that is often used is emulgel. In this study, diclofenac diethylamine levels in emulgel preparations were determined using NIR (Near-Infrared) spectroscopy and chemometric methods. Simulation samples were prepared and divided into 24 training sets and 9 test set samples. NIR spectra of training set samples were correlated with the concentration of diclofenac diethylamine using partial least squares (PLS), principal component regression (PCR), and support vector regression (SVR). The best model was validated using leave one out cross validation (LOOCV) and external validation using test set samples. The comparison method used in this study was the validated TLC Densitometry method. The best calibration model was PLS, with an R2 value of 0.990 and RMSE of 0.171. The results of R2 and RMSE of LOOCV were 0.989 up to 0.990 and 0.167 up to 0.178, respectively. The result of R2 and RMSEP external validation were 0.991 and 0.146, respectively. The precision and accuracy method showed RSD of 3.37% and a % recovery of 99.78%. The results of determining the sample levels obtained from NIR and TLC Densitometry methods tested with the Two-Paired Sample T Test and showed that the two methods have no significant differences with a significance value of more than 0.05.
DESAIN DAN PENGEMBANGAN MESIN MICRO-PRESS PEMBENTUK KOMPONEN MIKRO
Authors: Komara Asep Indra , Mahmudah Aida , Lestari Adinda Sri , Hasibuan Johanes C. J.
Published: January 2023

The increasing application of micro electro mechanical systems technology on daily life devices increases the need for micro components. Furthermore, it must be supported by reliable fabrication technology to produce micro-sized products. One of these technologies is micro-sheet metal forming, which is a forming technology from sheet metal with 10-300µm thickness. The development of this technology requires a special press machine that is used in the scope of micro-scale work, named micro-press. Micro-press is still rare due to it was used for individual experiment purposes. Thus, it is necessary to develop the micro-press to support research and manufacturing of micro-part. In this study, the design of a micro-press is intended to accommodate the miniaturization problems and to be easy in fabrication and re-fabrication. Then, the micro-press will contribute to fulfill the micro-parts need. By using the VDI 2222 design method, the design of a 5kN micro-press machine with a servo motor drive is obtained, and validation of construction strength was carried out with the help of the appropriate CAE software. The results of the design validation show that the construction of the micro-press machine is quite strong. The selected component has a strength specification that is greater than required, and the maximum stress that occurs in the frame, which is 80.096 N/mm2, is still very lower than the allowable stress on the SPHC material. The magnitude of the resultant displacement shows a fairly small value, i.e. 0.178 mm.
INVESTIGASI AREA SERRATED YIELDING PADA PADUAN 800H
Authors: Ekaputra I Made Wicaksana
Published: January 2023

Detailed information about the mechanical properties of components in the power plant was crucial in process design. One essential piece of information was the characteristics of the material at various temperatures in a tension load. In this study, the tensile test was applied to the Alloy 800H with various temperatures ranging from 24oC to 900oC at a constant deformation rate of 10-4/s. Alloy 800H was a promising candidate for components in power plants due to its high corrosion resistance in a high-temperature environment. A test was conducted by following the ASTM E8 and ASTM E21. The tensile apparatus was equipped with a furnace, and a thermocouple was attached to the specimen surface of the cylindrical during the test. The data was recorded by the data acquisition connected to the PC. This preliminary study aimed to determine the serrated yielding area that occurred based on several data from tensile test results.
EFFECT OF SHIELDING GAS ON THE PROPERTIES OF STAINLESS-STEEL SUS 304L PLUG WELDED
Authors: Habibi Ilham , Prasetyo Januar Tri , Muhayat Nurul , Triyono Triyono
Published: January 2023

The effect of shielding gas composition and welding current on the mechanical-physical properties of plug welding joint stainless steel SUS 304L has been investigated. Metal Inert Gas (MIG) welding was used to join SUS304L with a thickness of 3 mm. The variations of welding current were 80 A, 100 A, and 120 A, while variations of shielding gas composition were 100% Ar; 92,5% Ar-7,5% CO2; 85% Ar-15% CO2; 77,5% Ar-22,5% CO2; 100% CO2. Macro and microstructural tests were conducted to determine welded joints physical properties. Tensile-shear testing and micro hardness Vickers were done to determine welded joints physical properties. The results show that the higher level of welding current and CO2 content in the shielding gas, the more tensile-shear load bearing capacity and decreased hardness. The welding current of 120 A and shielding gas 77,5% Ar-22,5% CO2 produced welded joints with the highest tensile-shear load bearing capacity. The nugget size increased as the higher level of welding current and the CO2 content in the shielding gas due to the increase of heat input.
ANALISA KECEPATAN SLUG ALIRAN DUA FASE DI DOWNSTREAM T-JUNCTION MINICHANNEL HORIZONTAL DENGAN RADIUS BELOKAN (r/dh) 0.7
Authors: Dharma Untung Surya , Dwiputri Calista Anjani , Nugroho Eko , Asroni Asroni , Deendarlianto Deendarlianto , Indarto Indarto
Published: January 2023

Uneven distribution of the phases between in the main channel when two-phase flow passes through the T-junction it can cause the formation of slug flow which affects performance in the downstream area. The slug is formed due to the acceleration of the gas phase moving towards an average or stable velocity. The bend radius of the T-junction affects the formation of slug because the radius can increase the velocity of the gas phase. Research on the slug velocity was carried out in the downstream region of the horizontal mini channel T-junction. The working fluid used is air as the gas phase and water. The flow pattern and velocity slug analysis were carried out by visualizing the flow at a distance of ±30 mm from the T-junction, that works as a mixer of the working fluid. High-speed camera is used to record video and processed in the form of image processing with the MATLAB program. Two-phase flow slug velocity analysis conducted in the downstream area of ​​the horizontal minichannel T-junction, it can be concluded that the slug velocity tends to increase linearly with increasing superficial velocity of air and water. Comparison of slug velocity experimentally with the results of calculations using the equations of Fukano and Kariyasaki (1993) and Sudarja et al (2018) shows conformity with less than 10% of error margin, while Nicklin et al (1962) is ±30%.
CO-PYROLYSIS OF SCRAP TIRES (ST) DAN PLASTIK POLYPROPYLENE (PP): DISTRIBUSI PRODUK DAN PROPERTIS FISIK PYRO-OIL
Authors: Sofana Ilyas , Wijayanti Widya , Hamidi Nurkholis
Published: January 2023

Plastic waste and scrap tires (ST) have now become pollution that harms the environment in various cities around the world if not managed properly. As pollutants, the two types of waste are actually very interesting to manage because they contain hydrocarbon elements so that they can be processed and have the potential to become alternative fuels. This study aims to determine the effect of co-pyrolysis of scrap tires (ST) and polypropylene (PP) plastic on the distribution of products in the form of oil and char/charcoal. The pyrolysis process was carried out at a temperature of 450℃  for 90 minutes using a fixed bed pyrolysis reactor with ST:PP mixing variations, namely 9:1, 8:2, 7:3, 6:4, and 5:5. The maximum pyrolysis product yield in the form of oil as much as 40.7 Wt% was obtained at a 6:4 mixing variation followed by a 7:3 (36.7 Wt%) mixing variation, then a 5:5 variant (36 Wt%), after that an 8:2 variant (34.3 Wt%) and the last is the 9:1 mixing variation with a total of 28.3 Wt%. For the maximum pyrolysis product in the form of char as much as 42.6 Wt% obtained at 9:1 mixing variation followed by 7:3 mixing variation (41 Wt%) after that 8:2 variant with 38.7 Wt%, then 6:4 with the amount of 27.7 Wt%, and the last is the mixing variation of 5:5 to obtain the char result of 18.3 Wt%. Physical properties of pyro-oil in the form of density and calorific value will also be shown in this study.
Selection of alternative solution for implementing green productivity of milk agroindustry in Malang Raya
Authors: Linggar Rucitra Andan , Dyah Pitaloka Citraresmi Ardaneswari , Kartikaningrum Widhistya
Published: January 2023

The dairy agroindustry in Malang Raya has high development potential due to the increasing market demand for dairy products. Previous studies have analyzed the application of green productivity at SMEs Milk X in Malang City and proposed alternative solutions to make liquid organic fertilizers, install wastewater treatment equipment, and utilize wastewater as hydroponic growing media. This study aimed to follow up the results of previous studies, focusing on selecting alternative solutions to be applied to SMEs Milk X and analyze the green productivity index (GPI) value from the selected alternative solutions. In selecting alternatives, the analytical hierarchy process (AHP) method was used with data obtained from questionnaires. The results obtained indicate that the selected alternative solution that potentially to be applied in the SMEs Milk X was the manufacture of liquid organic fertilizer. In this alternative, the GPI value increased from 0.24 to 1.078.
PENGEMBANGAN SISTEM INSTRUMENTASI UNTUK MENGUKUR LEBAR KERJA (CUTTING WIDTH) PADA MINI COMBINE HARVESTER
Authors: Eka Putri Renny , Sandri Ade , Putri Irriwad
Published: January 2023

Pengukuran lebar kerja menggunakan sensor tentunya lebih efisien dan lebih akurat dibandingkan dengan pengukuran secara manual. Pengukuran lebar kerja ini dibutuhkan dalam penentuan hasil panen atau yang lebih dikenal dengan yield monitoring. Yield monitoring adalah salah satu teknologi pertanian presisi yang berfungsi untuk memonitoring hasil penentuan hasil panen secara langsung (real time). Teknologi ini mengumpulkan data berupa grain flow (ton/jam), lebar kerja (cutting width), kecepatan combine harvester (km/jam) dan grain moisture content (%). Pengukuran lebar kerja dilakukan dengan cara mengukur jarak antara pembacaan sensor pada header kiri dan kanan, kemudian dikurangi dengan lebar header. Pengukuran lebar kerja secara real time dibutuhkan pada pemantauan hasil panen yang dilakukan oleh mini combine harvester. Dalam proses pemanenan, mini combine harvester akan bekerja memotong padi. Lebar kerja biasanya dihitung dengan mengukur jarak dari header mini combine harvester. Tujuan dari penelitian ini adalah mengembangkan sistem pengukuran untuk lebar kerja (cutting width) pada mini combine harvester dan melakukan uji kinerja untuk sistem tersebut. Sistem instrumentasi yang dikembangkan dalam mengukur lebar kerja adalah dengan menggunakan Sensor ultrasonik US-100 sebagai sensor jarak kemudian ESP 32 sebagai mikrokontroler sekaligus modul WiFi yang akan dikoneksikan dengan database dan diinterpretasikan kedalam bentuk digital menggunakan LCD I2C. Dengan sistem ini dapat digunakan oleh petani untuk memantau hasil panennya secara langsung. Alat ini juga memudahkan petani untuk memasang atau melepaskan alat sesuai dengan kebutuhan karena bersifat “plug and play”
Analysis of the health status of medical workers based on the results of mandatory periodic examinations
Authors: Golovko E. A. , Nessina I. A. , Smirnova E. L. , Poteruaeva E. L. , Figurenko N. N. , Demeshko K. O.
Published: January 2023

Objective: to analyze the results of periodic medical examinations of employees of a large medical organization in dynamics, according to the final acts. Materials and methods: the research material was the final acts (2019–2021), compiled based on the results of periodic medical examinations of employees of the Novosibirsk Regional Clinical Hospital of War Veterans (Novosibirsk Regional Clinical Hospital of War Veterans). For the analysis, data on the structure of diseases for 2019–2021 were also used, with which medical workers underwent treatment courses in the day hospital of the hospital. Results: in just 3 years, 546 hospital employees under-went periodic medical examination, 489 of them women. The results of the studies have shown that in the dynamics of three-year follow-up, the number of persons subject to additional examination, treatment and dispensary observation has sharply increased, which may indicate a certain effectiveness of PMT. The detectability of chronic somatic diseases according to the results of the PMT has increased by more than 10 times in dynamics. 69 medical workers underwent treatment courses on the basis of the GNOCGV day hospital for 3 years. Of these, 22 medical workers were treated and rehabilitated in a day hospital with the consequences of a new COVID-19 coronavirus infection. Conclusion: when analyzing the final acts based on the results of the PMOS of GNOCGV employees for the period from 2019 to 2021, it was found that the efficiency and quality of inspections has increased dramatically.
Viral hepatitis B and C as occupational diseases
Authors: Yakupova F. M. , Garipova R. V. , Gilmullina F. S. , Sozinova J. M. , Zagidov M. M.
Published: January 2023

Objective: to study the clinical and epidemiological features and medical and social aspects of viral hepatitis B and C in medical workers. Materials and methods: analysis of outpatient and inpatient records of medical workers with a diagnosis of chronic viral hepatitis B, C, B + C, B + D of various stages and degrees of activity, registered at the Republican Center of Occupational Pathology of the Republic of Tatarstan and the consultative and diagnostic department of the Republican Infectious Clinical Hospital named after prof. A.F. Agafonov. An on-line sociological survey of medical workers and senior students of medical universities in Kazan was conducted using the Google form. Results: medical personnel whose work is associated with the provision of invasive medical interventions are at the highest risk of infection with blood-borne infections. All medical workers had a history of accidents - needle sticks, cuts, blood spatter. The development of liver cirrhosis and the presence of lethal outcomes in liver cirrhosis decompensation reflect the general problem of chronic hepatitis C - the lack of timely effective antiviral therapy, despite the detection of hepatitis viruses in medical workers in the early stages of infection during periodic medical examinations. Conclusions: in the structure of occupational morbidity among healthcare workers in Tatarstan, viral hepatitis makes up 16.7%. There is still a risk of viral hepatitis infection in MRs of any level of education and status, including students of medical universities during work practice, assistance on a volunteer basis. Vaccination/revaccination against viral hepatitis B is regulated by regulations and shown to all healthcare workers with viral hepatitis C.
The concept of healthy aging at work
Authors: Gantman A. A. , Gorblyansky Yu. Yu. , Kontorovich E. P. , Ponamareva O. P.
Published: January 2023

Based on a thematic review of research by foreign and domestic authors, the analysis of current trends in the aging of the population and labor force as a global demographic problem is carried out. The stages of formation of ideas about healthy aging in the world and Russia are presented. The risks of the development of premature aging and the prospects of prolonging the longevity of workers in modern conditions are considered.
Modern ideas about endometrial disorders with habitual miscarriage
Authors: Bazieva T. A. , Ordiyants I. M. , Dzhabrailova B. A. , Тunguzbieva R. U.
Published: January 2023

The cause of 75% of all implantation failures is impaired endometrial receptivity. Most of the implantation window markers studied are regulated by estradiol and progestrone. Steroid hormones are involved in the binding of molecular makers to specific nuclear receptors and any disturbance in steroid receptor expression can lead to impaired endometrial morphofunctional properties and receptivity. There are three levels of receptivity: genetic, proteomic, and morphological. According to genetic studies, during the implantation window period, there is a 10-fold increase in the expression of about 395 genes in parallel with a decrease in the expression of other 186 genes, various proteases, cell adhesion molecules and matrix proteins. Proteomic markers that affect endometrial receptivity include various growth factors, cytokines, cell adhesion molecules, and integrins. One of the main markers of the morphological level of receptivity is the pinopodia. Over the past 20 years, a large number of molecular markers of endometrial receptivity have been studied and the understanding of implantation mechanisms has expanded. But, despite this, no ideal marker for the assessment of endometrial receptivity in impaired fertility has been found. For the most accurate and effective diagnosis and to reduce the incidence of early reproductive loss, it is necessary to investigate all three levels of endometrial receptivity.
Introduction of a Single Electronic Health Record for Maternity Units in Ireland: Outline of the Experiences of the Project Management Team
Authors: Sheehan Orla Maria , Greene Richard Anthony , McKernan Joye , Murphy Brendan , Cahill Caroline , Cleary Brian , Lawlor Fiona , Robson Michael ,   MN-CMS National Project Team
Published: January 2023

Electronic health records (EHRs) are being introduced worldwide. The change from paper to electronic records has not always been a seamless or quick process; however, EHRs are viewed as central to updating modern health care, especially organization structures and delivery of sustainable care with the potential for joint decision-making with the patient. The objective of this viewpoint paper is to outline how an EHR is being developed in Ireland. The focus of the Maternal & Newborn Clinical Management System project is the design and implementation of an EHR for all women and babies in the maternity services in the Republic of Ireland. The paper also outlines the lessons learned from the planning to the optimization stage of the project. The paper was developed through discussions with the project management team and their completed reports that outline the lessons they acquired from each project stage. Key lessons learned from each stage of the project are highlighted. This viewpoint paper explains how the national project management team is implementing the EHR and outlines the experiences and lessons learned and the challenges ahead following the phase one introduction. The Maternal & Newborn Clinical Management System is an example of a clinician-led, patient-focused, change management project from its inception to implementation. The introduction of EHRs is essential in modernizing health care and optimizing patient outcomes through the accurate and appropriate use of data.
Digital Behavioral Activation Interventions During the Perinatal Period: Scoping Review
Authors: Mancinelli Elisa , Dell'Arciprete Gaia , Pattarozzi Davide , Gabrielli Silvia , Salcuni Silvia
Published: January 2023

Background

Pregnancy is a complex period that implies many biopsychosocial changes, and the way women adapt to these changes impacts their well-being and the chances of developing mental health problems. During the perinatal period, women have expressed a preference for support delivered on the web. In this regard, interventions such as behavioral activation (BA), which are brief and structured psychosocial interventions, seem particularly suited to be delivered through digital solutions.

Objective

This study aimed to map the literature investigating digital BA interventions deployed during the perinatal period. We paid particular attention to the methodological underpinnings of the studies, the potential impact of BA interventions on symptoms other than depression, and the existence of differences occurring when these interventions were administered during pregnancy versus the postpartum period.

Methods

A systematic search compliant with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews) guidelines was conducted considering 5 bibliographic databases; reference lists and key journals were also screened by 2 independent authors following a double-blind approach.

Results

A total of 7 studies published between 2013 and 2022 were included. In total, 2 studies were protocols for randomized controlled trials, 5 were empirical studies, and 1 was a qualitative study. All studies focused on the postpartum period, except for 1 that focused on the broader perinatal period. Promising effects on depression symptoms were reported but not on other psychosocial symptoms. Low intervention adherence has emerged, whereas the usability associated with the digital means used to deploy interventions was scarcely addressed; moreover, information on the digital platforms used was poorly reported overall.

Conclusions

Our findings highlight the scarcity and preliminary nature of digital BA interventions deployed during the perinatal period, where the focus seems more on treatment rather than prevention. Moreover, future studies should also consider and address usability and user engagement, given their relevance to intervention efficacy.
Dietary Temperature’s Influence on Energy Balance in Humans: Protocol for a Randomized Controlled Trial and Crossover Design
Authors: Rastmanesh Reza , Flack Kyle D
Published: January 2023

Background

According to the first law of thermodynamics, energy cannot be created or destroyed in an isolated system. Water has a characteristically high heat capacity, indicating that the temperature of ingested fluids and meals could contribute to energy homeostasis. Citing the underlying molecular mechanisms, we present a novel hypothesis that states that the temperature of one’s food and drink contributes to energy balance and plays a role in the development of obesity. We provide strong associations with certain molecular mechanisms that are activated by heat and correlate them with obesity and a hypothetical trial that could test this hypothesis. We conclude that if meal or drink temperature proves to contribute to energy homeostasis, then depending on its contribution and scale, future clinical trials should attempt to adjust this effect when analyzing data. In addition, previous research and established relationships of disease states with dietary patterns, energy intake, and food component intakes should be revisited. We understand the common assumption that thermal energy in food is absorbed by the body during digestion and dissipated as heat into the environment, not contributing to the energy balance. We challenge this assumption herein, including a proposed study design that would test our hypothesis.

Objective

This paper hypothesizes that the temperature of ingested foods or fluids influences energy homeostasis through the expression of heat shock proteins (HSPs), especially HSP-70 and HSP-90, which are expressed to a greater extent in obesity and are known to cause deficits in glucose metabolism.

Methods

We provide preliminary evidence supporting our hypothesis that greater dietary temperatures disproportionally induce activation of both intracellular and extracellular HSPs and that these HSPs influence energy balance and contribute to obesity.

Results

This trial protocol has not been initiated and funding has not been sought at the time of this publication.

Conclusions

To date, no clinical trials are available regarding the potential effects of meal and fluid temperature on weight status or its confounding effects in data analysis. A potential mechanism is proposed as a basis by which higher temperatures of foods and beverages might influence energy balance via HSP expression. On the basis of the evidence supporting our hypothesis, we propose a clinical trial that will further elucidate these mechanisms.

International Registered Report Identifier (IRRID)

PRR1-10.2196/42846
Web-Based Social Networks of Individuals With Adverse Childhood Experiences: Quantitative Study (Preprint)
Authors: Cao Yiding , Rajendran Suraj , Sundararajan Prathic , Law Royal , Bacon Sarah , Sumner Steven A , Masuda Naoki
Published: January 2023

BACKGROUND

Adverse childhood experiences (ACEs), which include abuse and neglect and various household challenges such as exposure to intimate partner violence and substance use in the home, can have negative impacts on the lifelong health of affected individuals. Among various strategies for mitigating the adverse effects of ACEs is to enhance connectedness and social support for those who have experienced them. However, how the social networks of those who experienced ACEs differ from the social networks of those who did not is poorly understood.

OBJECTIVE

In this study, we used Reddit and Twitter data to investigate and compare social networks between individuals with and without ACE exposure.

METHODS

We first used a neural network classifier to identify the presence or absence of public ACE disclosures in social media posts. We then analyzed egocentric social networks comparing individuals with self-reported ACEs with those with no reported history.

RESULTS

We found that, although individuals reporting ACEs had fewer total followers in web-based social networks, they had higher reciprocity in following behavior (ie, mutual following with other users), a higher tendency to follow and be followed by other individuals with ACEs, and a higher tendency to follow back individuals with ACEs rather than individuals without ACEs.

CONCLUSIONS

These results imply that individuals with ACEs may try to actively connect with others who have similar previous traumatic experiences as a positive connection and coping strategy. Supportive interpersonal connections on the web for individuals with ACEs appear to be a prevalent behavior and may be a way to enhance social connectedness and resilience in those who have experienced ACEs.
Determining Optimal Intervals for In-Person Visits During Video-Based Telemedicine Among Patients With Hypertension: Cluster Randomized Controlled Trial (Preprint)
Authors: Nishizaki Yuji , Kuroki Haruo , Ishii So , Ohtsu Shigeyuki , Watanabe Chizuru , Nishizawa Hiroto , Nagao Masashi , Nojima Masanori , Watanabe Ryo , Sato Daisuke , Sato Kensuke , Kawata Yumi , Wada Hiroo , Toyoda Goichiro , Ohbayashi Katsumi
Published: January 2023

BACKGROUND

Introducing telemedicine in outpatient treatment may improve patient satisfaction and convenience. However, the optimal in-person visit interval for video-based telemedicine among patients with hypertension remains unreported in Japan.

OBJECTIVE

We determined the optimal in-person visit interval for video-based telemedicine among patients with hypertension.

METHODS

This was a cluster randomized controlled noninferiority trial. The target sites were 8 clinics in Japan that had a telemedicine system, and the target patients were individuals with essential hypertension. Among patients receiving video-based telemedicine, those who underwent in-person visits at 6-month intervals were included in the intervention group, and those who underwent in-person visits at 3-month intervals were included in the control group. The follow-up period of the participants was 6 months. The primary end point of the study was the change in systolic blood pressure, and the secondary end points were the rate of treatment continuation after 6 months, patient satisfaction, health economic evaluation, and safety evaluation.

RESULTS

Overall, 64 patients were enrolled. Their mean age was 54.5 (SD 10.3) years, and 60.9% (39/64) of patients were male. For the primary end point, the odds ratio for the estimated difference in the change in systolic blood pressure between the 2 groups was 1.18 (90% CI –3.68 to 6.04). Notably, the criteria for noninferiority were met. Patient satisfaction was higher in the intervention group than in the control group. Furthermore, the indirect costs indicated that lost productivity was significantly lesser in the intervention group than in the control group. Moreover, the treatment continuation rate did not differ between the intervention and control groups, and there were no adverse events in either group.

CONCLUSIONS

Blood pressure control status and safety did not differ between the intervention and control groups. In-person visits at 6-month intervals may cause a societal cost reduction and improve patient satisfaction during video-based telemedicine.

CLINICALTRIAL

UMIN Clinical Trials Registry (UMIN-CTR) UMIN000040953; https://tinyurl.com/2p8devm9