bluuebunny/crossref_metadata_2025 huggingface dataset:
Ewolucja tematycznych obszarów współpracy transgranicznej w ramach programów UE w wybranych krajach Europy Środkowo-Wschodniej
Authors: Pieniążek Agnieszka
Published: January 2024

Współpraca transgraniczna polskich regionów z sąsiadującymi regionami w Czechach, Słowacji i Ukrainie wspierana była za pośrednictwem programów wspólnotowych już w latach 90. XX wieku. Na zdecydowanie większą skalę rozwinęła się jednak za pośrednictwem programów transgranicznych wdrażanych po akcesji Polski, Słowacji i Czech do Unii Europejskiej. Celem artykułu jest przedstawienie zmian celów i tematycznych obszarów wsparcia podejmowanych w programach współpracy transgranicznej: Republika Czeska-Polska, Republika Słowacka-Polska oraz Polska-Białoruś-Ukraina w dwóch unijnych perspektywach finansowych: 2004-2006 oraz 2014-2020. Artykuł jest próbą odpowiedzi na następujące pytania badawcze: Czy, a jeśli tak, to w jaki sposób zmieniły się cele współpracy transgranicznej? Czy istnieją różnice w zakresie tematycznych obszarów współpracy transgranicznej? Czy pomiędzy tematycznymi obszarami współpracy transgranicznej na pograniczu czesko-polskim i słowacko-polskim oraz polsko-białorusko-ukraińskim istnieją różnice? Analizie poddano dane zastane wykorzystując przede wszystkim metodę badania dokumentów programowych trzech programów współpracy transgranicznej realizowanych w dwóch okresach unijnego programowania. Badanie wykazało, iż cele współpracy transgranicznej w pierwszej perspektywie finansowej we wszystkich programach przedstawiały się w bardzo podobny sposób i generalnie dotyczyły poprawy standardu życia oraz integracji społeczno-gospodarczej sąsiadujących regionów. W ostatniej perspektywie cele te były zdecydowanie bardziej zróżnicowane i korespondowały z ówczesnymi potrzebami regionów objętych wsparciem. W przypadku pogranicza polsko-czeskiego i polsko-słowackiego wspólnym celem było inwestowanie w kształcenie, szkolenie oraz szkolenie zawodowe na rzecz zdobywania umiejętności i uczenia się przez całe życie. Natomiast w przypadku pogranicza polsko-słowackiego i polsko-białorusko-ukraińskiego wspólne okazały się następujące cele: zachowanie i ochrona środowiska naturalnego (w tym kulturowego) oraz poprawa dostępności regionów i rozwój transportu oraz sieci i systemów komunikacyjnych. Tematyczne obszary współpracy odpowiadały zdefiniowanym celom w ramach poszczególnych programów. W perspektywie 2004-2006 współpraca transgraniczna dotyczyła przede wszystkim rozwoju i modernizacji infrastruktury oraz szeroko rozumianego rozwoju społeczno-gospodarczego. W ostatniej perspektywie finansowej widoczna była konkretyzacja i specjalizacja obszarów wsparcia. W przypadku pogranicza polsko-białorusko-ukraińskiego szczególną uwagę zwrócono na zarzadzanie granicami, mobilnością i migracjami oraz bezpieczeństwem na granicach.
Zhaman-Koitass granite-leukogranite massif (Northern Kazakhstan): U-Pb age, mineralogical and geochemical features, geodynamic analysis
Authors: Vladimirov A. G. , Karpov A. V. , Annikova I. Yu. , Mikheev E. I.
Published: January 2024

Research subject. The Zhaman-Koitass granite-leucogranite massif of the Borovsk complex in Northern Kazakhstan. In the platform cover of the West Siberian plate, overlying granite-leucogranites, a large uranium deposit Semizbai of sandstone type is localized. Materials and methods. Geochemical, mineralogical, and geochronological studies of granite-leucogranites were conducted by X-ray fluorescence analysis, ICP-MS, electron probe microanalysis, scanning electron microscopy, and LA-ICP-MS (Analytical Center for multi-elemental and isotope research SB RAS). Results and conclusions. The Zhaman-Koitass massif is composed by A-type subalkaline leucogranites (SiO2 = 72.8–75.4 wt %, Na2O + K2O = 7.5–8.8 wt %, K2O/Na2O = 1.11–1.25, ∑REE = 120–231 ppm, (La/Yb)n = 10–22, Eu/Eu* = 0.2–0.4), which are characterized by titanite-ilmenite-magnetite accessory specialization. U-Pb isotope dating confirms the silurian age of the Zhaman-Koitass granite-leucogranites (426–420 Ma). The obtained geochronological data, along with the similarity of the chemical composition of the rocks, confirm that the granite-leucogranites of the Zhaman-Koitass massif belong to the Borovsk complex. The significant age interval between the ordovician granitoids of the krykkuduk complex (448 ± 2 Ma) and the silurian granite-leucogranites of the karabulak and borovsk complexes considered in the article (431–426 Ma) suggests a change in the geodynamic situation from suprasubduction to transform marginal-continental.
Determination of some heavy metals and physicochemical properties in contaminated soils of open waste dumpsite in Awka, Anambra State
Authors: Okakpu Ogochukwu J. , Okoye Patrice A. C. , Onuegbu Theresa U.
Published: January 2024

The current study was designed for the assessment of cadmium, chromium, lead, nickel, zinc and manganese and some physicochemical properties of soils collected from an open dumpsite in Awka, Nigeria. Soil samples at the depth (0-20 cm) were randomly collected at the dump field and were analyzed for physicochemical parameters and heavy metals using standard analytical methods. The results show that the main dumpsite had a high sand content (91.48% ± 0.26%) with a low silt 4.07% ± 0.03% and clay 4.65% ± 0.00%. The pH of the dumpsite soils was 6.07 ± 0.04 which is an acidic pH. Organic matter (%) and organic carbon (%) were 3.84 ± 0.06 and 2.23 ± 0.04 respectively. The EC (µS cm-1) was 476.9 ± 0.00 while the ECEC (cmol/kg) 18.93 ± 0.04. The bulk density (g cm-3) was 1.32 ± 0.00 and the porosity (%) of the dump soil was 41.40 ± 0.00. Total metal concentrations of Cd, Cr, Pb, Ni, Zn and Mn were also analyzed and the concentrations of the heavy metals at dumpsitewas obtained (28.35 ± 0.21 to 149.10 ± 0.01 mg/kg). Metal contamination at dumpsite was in the order of Mn ˃ Zn ˃ Pb ˃ Cd ˃ Cr ˃ Ni. The study evidently indicates the presence of heavy metal contamination in the dumpsite even though some of them fell below the critical permissible concentration level. However, it is their accumulation and persistence in the soils of the dump site that may be a cause of concern for their surrounding environment and organisms.
Modelos dimensionales adaptables con base en los factores de procesos académicos del modelo de acreditación institucional del CNA
Authors: Mendoza Becerra Martha Eliana , Fuentes Vargas David Antonio , Gómez Flórez Luis Carlos
Published: January 2024

En Colombia la entidad que se encarga de evaluar la calidad en la educación superior es el Consejo Nacional de Acreditación, el cual exige a las instituciones un informe de autoevaluación con datos cuantitativos, que muchas veces se convierte en un cuello de botella en este proceso debido a que los datos deben ser extraídos desde diversas fuentes. En este contexto, las Bodegas de Datos son una alternativa de solución, ya que permiten centralizar la información y apoyar la toma de decisiones. En este artículo se proponen siete modelos dimensionales enfocados en tres factores del CNA que se relacionan con Procesos Académicos: estudiantes, profesores y procesos académicos; y que son adaptables a los datos disponibles en las fuentes de las instituciones. Para el diseño de estos modelos, primero se revisó la literatura para identificar los modelos dimensionales existentes enfocados en procesos académicos. Luego se utilizó la metodología de desarrollo de DW para MiPymes, que permitió identificar los aspectos a evaluar de los factores de estudio de los lineamientos de acreditación, los requerimientos cuantitativos presentes en los informes de autoevaluación para estos factores, realizar un mapeo entre estos, y validar estos requerimientos por un grupo de expertas en acreditación. Luego se identificaron los modelos dimensionales a diseñar para cumplir con estos requerimientos y se validó la adaptabilidad de los mismos, por medio de un grupo de expertos en bodegas de datos, quienes consideraron que los siete modelos dimensionales propuestos tienen un grado de adaptabilidad del 100% a los requerimientos identificados, debido a que estos modelos pueden adaptarse a la información disponible en las instituciones de educación superior, con respecto a requerimientos más frecuentes, menos frecuentes y propuestos.
Construyendo Conexiones Emprendedoras: Diseño de una Red Social para la Comunidad Universitaria en el Departamento del Cauca
Authors: Ordoñez Quintero Cristian Camilo , Satizabal Clara , Ordoñez Eraso Hugo
Published: January 2024

Las redes sociales han asumido una función esencial debido a su capacidad para establecer conexiones entre individuos, facilitar la divulgación de información, fomentar la comunicación y habilitar interacciones en línea. Estas herramientas digitales se han vuelto aún más vitales en la era posterior al COVID-19, en vista de la significativa oleada de desempleo que ha surgido a raíz de la pandemia. Esta circunstancia ha generado la necesidad imperiosa de explorar nuevas vías para conectarse y perseguir oportunidades, donde las redes sociales ejercen un papel de suma importancia, como respuesta a estos desafíos contemporáneos, se ha desarrollado una red social específica para estimular emprendimientos locales, denominada DEAL. El objetivo principal de esta plataforma radica en conectar a jóvenes universitarios y miembros de la comunidad con ofertas de empleo, productos y servicios. El diseño y desarrollo de esta herramienta ha involucrado diversas metodologías, con el propósito de garantizar su funcionalidad y efectividad. DEAL ha sido ideado para operar en el entorno universitario de la ciudad de Popayán y se ha sometido a un proceso de implementación y evaluación exhaustivos, teniendo como resultado la vinculación de la comunidad académica a entornos sociales en red.
Challenges in Foamed Concrete: Exploring Alternative and Sustainable Materials – A Comprehensive Review
Authors: Madera Sierra Ingrid Elizabeth , Ramos-Escobar Camilo , Manuel A Rojas-Manzano
Published: January 2024

This document provides a contemporary overview of a wide array of aspects concerning foam concrete and its inherent properties. This review covers topics such as the use of alternative binders, the influence of water/cement ratio, fine aggregate replacements and an examination of mechanical properties. By meticulously scrutinizing compressive strength data from multiple authors, this exploration not only highlights the current state of knowledge but also underscores the potential for future investigations in the realm of foamed concrete. Similarly, this examination realizes the limitations that the unique structure of foamed concrete imposes on diverse applications in construction and engineering.
Level, structure and dynamics of drug trafficking
Authors: Kutsev Vladimir Valentinovich
Published: January 2024

The subject of this study is the level, structure and dynamics of crimes in the field of illicit drug trafficking. Some indicators of official statistics related to the operational situation in the fight against drug trafficking in the country are considered (the number of registered crimes, identification and suppression of drug distribution channels, etc.). The purpose of the study is to conduct a detailed analysis of statistical data on crimes related to drug trafficking, identify current problems in the fight against drug crime and formulate proposals for eliminating them. General scientific methods of cognition were used: the method of statistical analysis; method of analysis, synthesis; comparative method; methods of induction, deduction. An analysis of scientific literature has shown that the issues of drug crime are studied in domestic doctrine by many authors. In theory, issues related to crime rates, the impact of illegal migration on the drug situation in Russia, and the problems of investigating drug crimes committed using information technologies have been worked out. However, some aspects require further study. Within the framework of this study, an attempt was made to identify from the entire array the most pressing problems that require a speedy solution. In particular, it is proposed to reconsider the issue of the availability of electronic devices (vapes, electronic cigarettes) used by adolescents and young people to use psychoactive substances. A ban on the use of such devices should be established at the legislative level. It is concluded that the fight against drug crime must be comprehensive and carried out at several levels, including the prevention of drug crimes among minors.
Analisis Forensik Pada Instagram dan Tik Tok Dalam Mendapatkan Bukti Digital Dengan Menggunakan Metode NIST 800-86
Authors: Ali Diko Putra Muhammad , Wirawan Muhammad Arif , Parga Zen Bita , Yunita Kisworini Rianti , Rohayati Tuti
Published: January 2024

Crime is currently increasing with the development of this smartphone, one of which is the crime of using social media. Instagram and Tik Tok are one of the most widely used social media applications in this era. The more users of this social media, it does not rule out the emergence of crimes against fellow users of this social media. Every activity carried out on social media, including criminal acts, leaves evidence or digital traces; whether deleted or not, all will be visible. Digital forensics is the study of how to obtain digital evidence obtained from digital devices. This study aims to determine the process of finding digital evidence on Instagram and Tik Tok social media applications that are accessed via smartphones using the National Institute of Standards and Technology (NIST) method. The stages in this digital forensic method include Collection, Examination, Analysis, and Reporting to obtain digital evidence on Instagram and TikTok using tools in the form of third-party software, namely MOBILedit Forensic Express, Autopsy, and FTK Imager tools. With the final result for the Instagram application tools, MOBILedit Forensic Express is able to acquire evidence with a percentage of 0.02%, for autopsy tools at 40%, and FTK Imager with a percentage of 57%. In the Tiktok application itself, MOBILedit Forensic Express gets a percentage of 27%, while an autopsy is 29%, and the last is the FTK Imager tool with a percentage of 71%. In this study, the FTK Imager tool is superior in the acquisition of evidence between the two tools.
PENGARUH STRATEGI PEMASARAN, KEPEMIMPINAN, RISIKO SUKU BUNGA TERHADAP KINERJA KEUANGAN KOPERASI SIMPAN PINJAM
Authors: Sari Agnes Kartika Mutiara , Ridaryanto Petrus
Published: January 2024

The purpose of this study is to examine the effect of marketing strategy, leadership and interest rate risk on the financial performance of Credit Union. The sample of this study is 44 Credit Union members of the Credit Union Central of Jakarta. The author conducted a questionnaire survey to collect data and test the hypotheses developed in this study. the author sent the questionnaires to the boards and managers of Credit Union. Regression analysis of multiple linear was applied to analyze the data. The results show that leadership has a positive and significant effect on the financial performance of Credit Union. Marketing strategy and interest rate risk have no effect on the financial performance of Credit Union.The results of this study can be used as consideration for the Credit Union to improve skills leadership of the boards and managers.The study has three limitation. First the authors collect data from Credit Union to minimize the effect of data heterogeneity. To improve the generalizability of the study, future study might consider using data from other types of cooperatives. Second, this study uses primary data so it has risks respondent subjectivity, future study might use different ways of measuring interest rate risk using more objective empirical proxies such as income gap
PENGARUH KOMPENSASI BONUS DAN LEVERAGE TERHADAP MANAJEMEN LABA YANG DIMODERASI OLEH VARIABEL UKURAN PERUSAHAAN
Authors: Pangaribuan David , Rely Gilbert , Aditia Dimas
Published: January 2024

This study aims to analyze and test empirically the effect of bonus compensation, leverage and moderating company size on earnings management practices in Food and Beverage Sub-Sector Companies Listed on the Indonesia Stock Exchange Period 2018 – 2021). This research is a quantitative research using purposive sampling with 45 samples. The results of the study show that bonus compensation, leverage and firm size have a positive effect on earnings management. Furthermore, company size moderates Bonus Compensation and leverage on earnings management. Suggestions for future research need to link earnings management practices with good governance, profitability, and audit quality and expand the research sample using a cross section or time series with a longer time horizon.
Abordagem de comorbidades da senilidade na urgência e emergência: um relato de experiência
Authors: Rodrigues Maria Antonia Camillo , Andrade Eduardo Barion de , Gomes Marina Paula , Alarcon Sâmia Marangoni , Alves Laís , França Thiago Felipe , Ieiri Ieda Sayuri Lourenço dos Santos , Silva Ana Flávia Rezende e , Silva Adriano Leite , Parnaíba Diego Souza
Published: January 2024

Objetivo: Descrever os aprendizados e experiências de um estágio em um Pronto Socorro, além do contato com o paciente que está em processo de senilidade e que possui diversas comorbidades, dando ênfase a doença arterial obstrutiva periférica. Relato de experiência: Baseado na visita em um Pronto Socorro, tendo sido desenvolvido um acompanhamento do paciente por 2 discentes do curso de medicina, supervisionado pelo médico plantonista. Tal atividade foi promovida pela Liga Acadêmica de Urgência e Emergência, a fim de promover o aperfeiçoamento teórico e prático das diversas comorbidades e do processo de senilidade do paciente. Considerações finais: O processo de senilidade implica em alterações de hábitos não só do paciente, mas também da família, uma vez que a progressão do mesmo promove limitações físicas, funcionais, emocionais e sociais. Essas limitações são ainda mais sérias em pacientes que possuem algumas morbidades associadas e hábitos de vida comprometedores, promovendo alterações na qualidade de vida do indivíduo. Por fim, torna-se imprescindível uma abordagem humanizada, ética e empática por parte da equipe de saúde para com o paciente e seus familiares, sendo fundamental para uma melhoria na qualidade da vida e um melhor entendimento sobre os pacientes portadores de doenças crônicas e do seu processo de senilidade.
Pre-clinical Study of Marketed Polyherbal Formulations on Blood Glucose Level and Associated Parameters in Streptozotocin-induced Diabetes
Authors: K K Nikumbh , R A Patil , C D Upasani
Published: January 2024

The management of diabetes mellitus involves lowering blood glucose levels with anti-diabetic drugs. Globally and nationally, the demand for herbal goods is increasing correspondingly. There have been numerous polyherbal preparations with anti-diabetic activity discovered during the past few decades. For both their antidiabetes and potential to avert diabetic complications, two different commercial polyherbal preparations were tested. For the purpose of choosing a commercial polyherbal formulation, a survey was conducted. The formulations were chosen based on their similarity in terms of their constituents, their estimated efficacy, how frequently they were distributed, and their price range. STZ-induced diabetic rats were utilized as a model and metformin was the standard medication for evaluating the antidiabetic activity. Selected polyherbal formulations, including formulation A and formulation B, demonstrated effective anti-diabetic action. In comparison to diabetic control groups, polyherbal formulations meaningfully decreased glucose levels in diabetic rat’s blood and other diabetic complications metrics such as serum Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT), triglyceride, and cholesterol, as a marker for liver problems, and organ weight variation.
Solubility and Taste Masked Behaviour of Cyclodextrin Molecular Inclusion Complex of Artemether
Authors: Bijwar Rahul , Tare Harshal
Published: January 2024

Artemether by forming a complex with β-cyclodextrine (βCD) is used to improve solubility and taste masked by the kneading method. Artemether with β-cyclodextrine complex prepared with βCD in a drug-polymer ratio 1:1 gave complete taste masking with the satisfactory result obtained in term of in-vivo and in-vitro evaluation. The standard calibration curve of Artemether shows a slope of 0.0154 and a correlation coefficient of 0.9992. Compatibility studies show that drugs are compatible with polymers. Solubility studies show that the solubility of drug are increased in Phosphate buffer 6.8 by successfully forming a complex with βCD. In-vitro dissolution results showed that a maximum of 97.05% of Artemether, drug release less than 15 minutes in formulation. The solubility of Artemether in saliva (PH 6.8) is 0.00735 mg/mL, After complex forming with β-cyclodextrin the solubility of (Artemether complex) is 0.124 mg/mL. In-vitro drug release investigation, taste masking occurs when the amount of drug substance in the dissolve medium is either not identified or is below the threshold for recognizing its flavor in the early time points (between 0 and 5 minutes). Taste masking ( Taste perception test) 11 volunteers were selected for this test, results show that complex is taste masked. Artemether with βCD complex is a hopeful method to augment the solubility, dissolution and taste masking of the drug.
Docking Techniques for Unravelling the Molecular Mechanisms of Specioside of Kigelia africana Fruits
Authors: R Jubilee , M Komala
Published: January 2024

In this study, the inhibitors of α-amylase and aldose reductase, the key of proteins in diabetes mellitus, were isolated as compound speciosides from the Kigelia africana fruit Benth. Speciosides were selected as ligands for the receptors of α-amylase and aldose reductase in the molecular docking studies used by PyRx (0.8) for the inhibition of α-amylase and aldose reductase. The results showed that the α-amylase binding energy was 8.1 kcal/mol and aldose reductase was -9 kcal/mol. The ADME process showed that it was easily absorbed orally and distributed through the CNS, metabolized by CYP2D6, and excreted through renal Toxicity studies of speciosides showed no hepatotoxicity or skin sensitization. The in-silico studies of specioside compounds led to the development of potent α-amylase and aldose reductase inhibitors used to treat diabetic mellitus.
Ranolazine Quantification in Human Plasma: A QbD-Guided LC-MS Method Development and Validation
Authors: Farooq Jagirdar SZ , Khan Furquan N
Published: January 2024

The present research outlines a comprehensive and systematic approach for the development and validation of a bioanalytical Liquid chromatography–mass spectrometry (LC-MS) method to quantify ranolazine in human plasma. The study employs principles of quality by design (QbD) to enhance method robustness, precision, and accuracy. The primary goals of this research were to create a reliable LC-MS method for the accurate quantification of ranolazine in human plasma and to validate this approach in accordance with established standards set by regulatory bodies. A secondary objective was to explore the application of QbD principles to optimize method performance. The study resulted in the successful development of an LC-MS method that exhibits exceptional specificity, sensitivity, accuracy, and precision in the quantification of ranolazine in human plasma. Specificity tests revealed no interference from endogenous plasma components. The method demonstrated good sensitivity with limit of quantitation (LoQ) of 5 ng/mL and limit of detection (LoD) of 2 ng/mL. Accuracy, as assessed through recovery studies, showed mean recoveries of 98, 99, and 101% for three different spiked concentrations. Precision, expressed as RSD, was below 5% for both intra-day and inter-day analyses. Linearity studies resulted in a calibration curve with an R² value of 0.9998. By employing QbD principles, the method demonstrated improved robustness, thus minimizing the impact of variability during sample analysis. Robustness experiments revealed minimal effects on precision and accuracy when varying critical parameters. This research not only presents a reliable LC-MS method for ranolazine quantification but also underscores the importance of incorporating QbD principles in bioanalytical method development. The validated method holds significant implications for clinical research, pharmacokinetic studies, and therapeutic drug monitoring. By enhancing the accuracy and robustness of ranolazine quantification, this method contributes to the advancement of pharmaceutical and clinical research, ultimately benefiting patient care and treatment outcomes.
Evaluation of the Effect of Some Plant Extracts as Antifungal Substances Isolated from Patients with Gingivitis and Endophthalmitis in Hilla City
Authors: Al-demirchi Jehan Y , Kadhim Oras , Kadhim Abed J , Al-Hamdani Mais M , Al-Hussainawy Mohammed K , Al-Jassani Mohammad J
Published: January 2024

During this study, 8 isolates of Candida yeast were isolated and diagnosed on CHROMagar, and Candida albicans was the most prevalent species by 75%. The inhibitory activity of plant extracts of adrak, cloves, green tea, and cinnamon was tested by disc diffusion test against C. albicans, C. krusei, and the antibiotics gentian stain, fluconazole, kenazole, nystatin were used for comparison. As well as using oral and dental cleaning products for comparison as well. The study showed that clove extract had a weak inhibitory activity at a high concentration, while extracts of green tea, cinnamon and mint did not show any activity in inhibiting C. albicans and showed that toothpaste had high activity in inhibiting yeast better than the plant extracts that did not show any inhibitory effect despite their use in high concentrations. We conclude from the current study that it is better to use toothpaste instead of herbs to get rid of gingivitis because it plays a major role in inhibiting Candida yeast.
Determination of Paraphenylenediamine in Hair Dyes Formulation Using Visible Spectroscopy
Authors: Archana Gahtori , Pawnesh Patni , Tanya Sehgal , Taniya Dimri
Published: January 2024

Paraphenylenediamine (PPD), which stands for para-phenylenediamine, is a substance commonly present in hair dyes and is a potent sensitizer and reported to have adverse effects, including skin rashes, allergies, etc. This research study introduces a newly developed and rigorously tested visible spectrophotometric technique for accurately measuring the quantity of PPD in hair dye products. The proposed method relies on a colorimetric reaction between PPD and Folin–Ciocalteu phenol (FC) reagent in the presence of sodium hydroxide (NaOH), which results in a PPD-Folin’s reagent complex that is blue in color. To create a standard calibration curve, various concentrations of PPD solutions within the range of 2 to 10 μg/mL, dissolved in 0.1N NaOH, were combined with 1.5 mL of FC reagent solution and scanned at 645 nm. The method was then used to estimate the amount of PPD in three marketed hair dye formulations. The technique demonstrated accuracy and precision, with a detection limit of 0.2445 μg/mL and a quantification limit of 0.7411 μg/mL. The level of PPD observed in three marketed formulations was between 10 to 12.5 μg/mL. During the study, it was observed that the black henna pack contained high concentrations of PPD
Recovery of Stressed Escherichia coli Culturability using Selective Media with Penicillin Binding Proteins for Bioburden Testing
Authors: Kumar Baswa J , Prasuna R G
Published: January 2024

This study aimed to assess the effectiveness of selective media enriched with Penicillin-binding proteins (PBPs) in bioburden testing and the recovery of stressed Escherichia coli. Five distinct E. coli strains were subjected to experimentation utilizing two antibiotics to induce stress, simulating real-world scenarios where bacteria face various stressors, including antibiotics. The deliberate stress induction aimed to observe how stressed bacteria respond and recover in the presence of PBPs, vital cell wall components targeted by antibiotics. Multiple antibiotics ensured a comprehensive evaluation of stress responses. PBP1 tended to have a milder inhibitory effect on bacterial growth compared to both PBP2 and PBP3 across various growth media and strains. PBP2 demonstrated variable effects, displaying a nuanced impact depending on the growth medium and strain. In contrast, PBP3 consistently exerted a stronger inhibitory effect on bacterial growth. The strain of E. coli exhibited a significant influence on growth characteristics, reflecting strain-dependent responses to experimental conditions. Growth media and specific PBPs also displayed notable effects on colony forming units (CFUs) and percentage recovery (PR). Modified media generally supported higher CFUs and PR compared to standard media, showcasing the importance of media composition. Buffer choice also significantly impacted CFUs and PR, underlining the need for careful buffer standardization. Overall, the type of PBP used significantly affected E. coli colony numbers, as indicated by a highly significant p-value (p≈2.04×10-16). This study’s insights into the impact of selective media, PBPs, and bacterial strains on stressed E. coli recovery contribute to optimizing recovery protocols in microbiological studies. Comparisons between penicillin and cefixime treatments revealed higher CFU values in modified media, indicating their efficacy. Different PBPs showcased variations in CFU and PR, emphasizing their role in stressed E. coli recovery. The study sheds light on the multifaceted interactions between antibiotics, PBPs, media, and bacterial strains, vital for understanding antibiotic responses. These findings provide critical insights into designing effective recovery strategies and advancing microbiological studies.
Extraction, Isolation, Characterisation and Pharmacological Investigations of Beta Escin from Horse Chest Nut Seed Extract
Authors: Chougule Poonam , Koumaravelou Kailasam , Chougule Nilesh
Published: January 2024

Horse chestnut seeds (Aesculus hippocastanum) have long been recognized for their potential therapeutic properties, particularly due to the presence of bioactive compounds like beta-escin. This study aimed to comprehensively explore the extraction, isolation, characterization, and pharmacological investigations of beta escin from horse chestnut seed extract. Beta escin was extracted from horse chestnut seeds through a series of solvent extraction and purification steps. The isolated compound was then characterized using various analytical techniques, including UV, IR, DSC, X-RPD and GC/MS. Pharmacological studies were carried out to evaluate beta-escin’s possible medicinal applications. In this anti-inflammatory investigation, it was found that the carrageenan-induced reduction in swelling in diclofenac gel begins after 30 minutes, with a value of 11.71%, whereas the effect of escin gel takes 60 minutes to manifest, with a value that is slightly lower at 4.55%. Pharmacological research demonstrated a variety of positive benefits, such as anti-inflammatory, antioxidant, and vascular protecting qualities, which may have prospective uses in the treatment of edema and chronic venous insufficiency.
Formulation Development and Characterization of Acitretin Proniosomal gel: In-vivo Exploration against Imiquimod-induced Psoriasis in Experimental Animals
Authors: Gudalwar Bhushan R , Shukla Tarkeshwar P
Published: January 2024

he main purpose of this study was to prepare and evaluate acitretin proniosomal gel (APG) and find out if the antipsoriatic formulation could prevent Imiquimod (IMQ) induced psoriasis in experimental animals. APG was developed and by coacervation phase separation method. Cholesterol and soya lecithin was used as membrane modifiers and tween 80 and span 60 as non-ionic surfactants. Characterization of the prepared proniosomal gel revealed that the optimized batch APG3 presented excellent formulation characteristics like the viscosity of 9710 ± 1.24 cps, rate of spontaneity as 13 ± 0.86, %entrapment efficiency of 94.91 ± 0.51, average hydrodynamic diameter of niosomes as 345.7 nm, polydispersibility index as 0.159 and ZP of -2.3 mV. In-vivo animal study of the optimized batch APG3 was performed along with biochemical estimations of oxidative parameters as glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA) and catalase; also, TNF-α, IL-6 were estimated using ELISA sandwiched. Histopathological estimation along with psoriasis area severity index (PASI) scores in the IMQ-induced psoriatic model presented a significant fall in the scoring after treatment with APG3 compared with a psoriatic group. Primary dermal irritation scoring was also evaluated on Sprague Dawley rats. The results presented a considerable decline in skin irritation score compared with a psoriatic group. Also, the levels of GSH, SOD and catalase were increased in APG3 treated group as compared with a psoriatic group. While MDA level is decreased after topical treatment with APG3 compared with a psoriatic group. In conclusion, the optimized APG3 showed promising pharmacological effects in the treatment of psoriasis.
Anti-Angiogenic Effect of Clerodendreme inerme Leaves Extract
Authors: Kotagiri Mrunalini D , Kumar G Shiva
Published: January 2024

Clerodendrum inerme, a medicinal plant, exhibits diverse pharmacological properties. Various species within the Clerodendrum genus have been traditionally utilized in indigenous medical systems and folk remedies. This study intended to scrutinize the anti-angiogenic possibility of CI through in-ovo, in-vitro, and in-vivo approaches. The screening methods employed include the chick chorioallantoic membrane test (in-ovo), sponge bud technique (in-vivo), as well as in-vitro assays for cell migration, cell proliferation, along with morphogenesis. Statistical analyses involved Dunnett’s test for mean comparisons, utilizing one-way ANOVA. In the chick chorioallantoic membrane assay, both angiogenic score and branching points were evaluated. Notably, CI exhibited noteworthy antiangiogenic effects. In the sponge implantation technique, CI at specified dosages resulted in a substantial reduction in sponge weights, the formation of new vessels, and hemoglobin levels. The antiangiogenic effects were particularly pronounced with increasing doses. Furthermore, on endothelial cells, C. inerme demonstrated a dose-dependent decrease in migration, proliferation, and tube length, indicating potent antiangiogenic properties. In summary, this research underscores the considerable antiangiogenic potential of CI by various assays.
Diuretic Activity of Hydroalcoholic Extract of Peristrophe bicalyculata (R.) Nees. Leaves in Saline Loaded Rats
Authors: Dwivedi Sumeet , Chhajed Mahavir , Chabra Gurmeet , Jadhav Sujit A , Goyanar Gaurav , Choudhary Navin K
Published: January 2024

Peristrophe bicalyculata (R.) Nees. (PB) is one of the most widely medicinal plants used in ancient folklore to treat a number of diseases. In the present investigation, the diuretic activity of hydroalcoholic extract of leaves of selected plant was evaluated in saline-loaded rats. Rats weighing in between 180 to 200 gm of either sex were taken for the present study and concentration of urinary NA+K+ and Cl- was determined to access the memorandum of association (MOA). The hydroalcoholic extract of PB leaves at the test dose of 250 mg/kg bw showed significant diuresis in 3 hours while at the test dose of 500 mg/kg bw produced substantial diuresis at the end of 4 hours.
Extraction, Phytochemical Screening and HPTLC Analysis of Fenugreek Gum for Analysis of Different Phytoconstituents
Authors: Lade Pravinkumar D , Singla Neelam
Published: January 2024

Fenugreek gum is a natural polysaccharide that has been explored for various biomedical applications. The present study investigated the phytoconstituent profile of fenugreek gum, revealing it as a potent source of diverse bioactive compounds. The analysis encompassed steroids, fats and oils, alkaloids, proteins, saponins, tannins, phenolics, flavonoids, and carbohydrates. Extraction using methanol and aqueous solvents demonstrated the highest concentration of phytoconstituents, underscoring the efficacy of these solvents in isolating bioactive components from fenugreek. Further exploration involved the determination of Rf values and percentage area in chloroform, petroleum ether, and chloroform extracts, providing a comprehensive identification of the mixture’s components. The results suggested a rich and varied chemical composition in fenugreek gum, offering potential applications in diverse fields owing to the presence of steroids for physiological effects, fats and oils for nutritional benefits, alkaloids with potential pharmacological properties, proteins for cellular functions, saponins for their soap-like properties, and tannins and phenolics as antioxidants. Additionally, the presence of flavonoids and carbohydrates adds to its nutritional and medicinal value. The study’s findings contribute valuable insights into the phytochemical composition of fenugreek gum, shedding light on its potential applications in the realms of medicine, nutrition, and industry. The identification of optimal extraction methods and the characterization of phytoconstituents lay the foundation for future research and utilization of fenugreek gum as a versatile and valuable natural resource. Overall, this investigation underscores the significance of fenugreek gum as a rich repository of bioactive compounds with diverse potential applications across various domains.
Assessing Medicinal Plant Extracts in Strengthening Anti-Dandruff Shampoo: An Analysis Using Multi-Criteria Decision-Making Techniques
Authors: Tiwari Vibha , More Sarla , Gulia Suman , Selwyn T Sunder , Ramachandran M
Published: January 2024

Currently, more than half of the global population grapples with dandruff. The presence of the Malassezia fungus significantly contributes to this condition by potentially triggering the production of cytokines in keratinocytes, the cells responsible for synthesizing keratin and activating inflammatory pathways. Given the distress caused by dandruff, considerable efforts are underway to find effective treatments. Numerous studies centered on medicinal plants suggest promising efficacy in addressing this issue. This particular research focuses on conducting a clinical trial to explore the effectiveness of zinc L-pyrrolidone carboxylic acid and pirocton olamine, combined with extracts from six medicinal plants, for dandruff therapy. In this study, a combination of methanolic extracts from alternatives, along with pirocton olamine and zinc-PCA in the form of shampoo, was applied to a group of 30 individuals experiencing dandruff. This treatment regimen was carried out over a span of two months to assess its effectiveness in managing dandruff. Notably, 15 patients with persistent dandruff experienced significant relief within the initial two weeks. Another 12 patients noticed dandruff reduction after 28 days, the majority experienced relief within the first few weeks, and by the end of the fifth week, those remaining also expressed satisfaction with the treatment. These results strongly highlight the impressive effectiveness of medicinal plant extracts in alleviating dandruff, accompanied by minimal side effects, albeit requiring extended treatment duration. The research indicates that blending medicinal plant extracts with both natural and chemical compounds in pharmaceutical formulations shows potential for enhancing the effectiveness of dandruff treatments.
A Novel Stability Indicating RP-HPLC with PDA Approach for Estimation of Voclosporin in Bulk and Marketed Formulation
Authors: Ponnekanti Krishnaphanisri , Godela Ramreddy , Addanki Anusha , Doddi Dimpu SV , Burjukindi Deepika B , Dolla Harish , Gunnala Nagavamshi
Published: January 2024

An easy, specific, and reliable method for determining voclosporin has been established using the reversed phase-high performance liquid chromatography (RP-HPLC) approach. Chromatographic conditions included stationary phase C18 Kromasil (250 mm x 4.6 mm and 5 μm), solvent system (0.1% OPA: Acetonitrile) in a 60:40 ratio, 1-mL/min flow rate, and detection wavelength of 282 nm were opted to separate the voclosporin with retention time of 2.2 minutes. A linearity analysis was performed between 3.95 to 23.7 μg/mL, and the R2 value was found to be 0.999. Precision’s %RSD was determined to be between 0.4 and 0.7. The limit of detection (LoD) and limit of quantitation (LoQ) values are 0.01 and 0.03 μg/mL, respectively. Using the aforesaid approach, the %assay of the marketed formulation was 99.07%. To test the stability representing characteristics of the suggested approach, forced degradation experiments of voclosporin were performed and %degradation was measured. Because the procedure was easy, precise, accurate, and cost-effective, it may be poted for regular analysis of quality control samples in industry
Exploring the Therapeutic Potential of Azadirachta indica (Neem): Recent Advances and Applications
Authors: Dhakar Suresh , Jain Sachin K , Tare Harshal
Published: January 2024

This review explains the therapeutic prospective of Azadirachta indica (Neem), a traditional medicinal tree in India, Southeast Asia, and Africa. Neem extracts have been found to have various therapeutic properties, including antimicrobial, antifungal, hepatoprotective, antiulcer, antifertility, and antinociceptive properties. Recent research has shown neem’s potential as an antiviral agent, cancer treatment, and a source of antibiotic compounds. Neem oil nano hydrogel shows significant antimicrobial activity against various pathogens. The plant also has the potential to mitigate heavy metal pollution and develop a model for predicting soil remediation using neem leaves. Neem’s inhibitory activity on papain-like protease of SARS-CoV-2 is also explored. Overall, neem’s therapeutic potential is significant and its potential in healthcare and environmental remediation is highlighted.
A Review of the Psychological Aspects of Childhood Obesity: Causes, Consequences and Treatment
Authors: Hupparage Vrushabh , Waman Tanaya , Waman Pradnya , Yadav Pooja , Tare Harshal , Dama Ganesh
Published: January 2024

The psychological and social effects of the worldwide epidemic of childhood obesity are widespread. Psychosocial factors may play role in childhood fatness, and this has piqued the curiosity of researchers. Childhood obesity is connected through psychological and social consequences such as physical inactivity, negative social interactions, stress, depression and anxiety and lower self-esteem and symptoms of psychiatric dysfunction. The purpose of this review was to broaden knowledge of childhood obesity-related treatment, causes, and consequences. This article also elaborates the evidence-based diagnosis, current treatment involves dietary management, psychosocial involvement, behavioral modification and some traditional medicine used for the treatment of obesity.
Nanosponges- A Versatile Approach of Drug Delivery System
Authors: Singh Alka , Chauhan Chetan S
Published: January 2024

With the escalating number of diseases, an opportunistic target drug delivery system is needed. Nanosponges (NS) are nanosized drug delivery systems having three-dimensional (3D) configurations, fabricated by crosslinking of polymers to ensnare a wide assortment of drugs. These small particles move inside the body till they arrive at the target site and deliver the medication in a specific and controlled way. They can ensnare (entrap) both hydrophilic and hydrophobic moieties in a smarter manner and improve the solubility and bioavailability of drugs. NS have been utilized to examine the medication conveyance by oral, parenteral, and topical routes. Another significant property of NS is that they can work on the solvency of ineffectively water-soluble moieties and are utilized for the storage of gases, and proteins as well as for the removal of toxins from the systemic circulation. The present review highlights the types of nanosponges, their methods of preparation, characterization, and applications in drug delivery.
Gastro Retentive Drug Delivery System: Latest Approach towards Novel Drug Delivery
Authors: Prasad Devi , Parashar Tarun , Khaudiyal Shivansh , Semwal Akanksha , Jakhmola Vikash
Published: January 2024

Various efforts have been undertaken to enhance the bioavailability and clinical performance of oral drug formulations. In pursuit of improving the therapeutic effectiveness of medications that are susceptible to degradation in alkaline pH environments, possess a limited window for absorption within the stomach, and readily dissolve under acidic conditions, a diverse range of gastro-retentive drug delivery systems (GRDDS) have been innovatively designed and developed. As a result, the stomach’s physiological state and the various factors that influence GRDDS will be discussed. As a rule, this survey will enlighten and coordinate enumerating scientists in arranging, plan, and planning the GRDDS.
Exploring the Multifaceted Potential of Annona squamosa: A Natural Treasure for Health and Wellness
Authors: Dhakar Suresh , Jain Sachin K , Tare Harshal
Published: January 2024

This article gives an in-depth look at the tropical fruit Annona squamosa L., which has a long history of traditional medicinal usage and is discussed in this review for its phytochemical and pharmacological qualities. The botanical specimen showcases an extensive assortment of bioactive constituents, encompassing glycosides, proteins, carbohydrates, saponins, alkaloids, flavonoids, and phenolics, which have significant antioxidant, antibacterial, antiviral, anticancer, antidiabetic, anti-inflammatory, anti-ulcer, and skin-protective properties. The leaves contain high protein content and essential oils amusing in terpenes and sesquiterpenes, which have shown potential in treating health conditions
Neurobiological Investigation of Depression: Unraveling the Biological Basis of a Complex Mental Health Challenge
Authors: Panigrahy Archana , Prusty Shakti Ketan , Panigrahi Ghanshyam
Published: January 2024

Individual depressive theories founded on neurobiological information are examined because they hold great relevance to both clinical investigators seeking to create innovative treatments for depression and physicians in everyday practice. One such theory is the proposition that the main underlying issue behind depressive disorders is a deficiency in central monoaminergic function. This theory highlights the importance of addressing the role of neurotransmitters such as glutamate, gamma-aminobutyric acid (GABA), norepinephrine, serotonin, and dopamine, as well as factors like neurocircuitry, neurotrophic factors, and the rhythm of the circadian clock. Major depressive disorder, a severe condition with significant societal and therapeutic implications, necessitates tailored antidepressant treatments. These treatments encompass both pharmacological interventions and emotional therapies, all of which need to be customized based on specific patients and medical circumstances. The understanding of depression is complex and constantly evolving, with various explanations and theories applying only to specific types of depressed individuals while disregarding others. Furthermore, the pathogenesis of depression can undergo significant changes during the disease’s development. This dynamic nature challenges the notion that depression can be characterized by a single hypothesis or theory. Thus, the extensive body of available research highlights the need for a comprehensive approach that incorporates multiple concepts and factors when studying and treating depression. By considering the intricate interplay of various neurobiological elements and personal circumstances, researchers and medical professionals can strive to provide more effective and tailored interventions for individuals suffering from depression.