bluuebunny/crossref_metadata_2025 huggingface dataset:
Transformando o Controle da Fertilidade: Desenvolvimentos e Perspectivas na Contracepção Masculina
Authors: Ferreira de Paula Castro Vívian , Giovana do Carmo Lima  , Lívia Nogueira de Freitas  , Vitor Roque Sauer  , Bernardo Augusto Barancelli  , Esther Fernanda Sasse Eichstadt  , Julia Colpani Donida  , Thais Tokumoto  , Vanessa Mazzardo
Published: September 2024

Nas últimas décadas, a contracepção masculina tem emergido como um campo de pesquisa crucial, impulsionado pela demanda por métodos eficazes e reversíveis que permitam uma distribuição mais equitativa da responsabilidade contraceptiva entre homens e mulheres. As opções tradicionais, como vasectomia e preservativos, são limitadas em termos de eficácia e aceitação social, o que motivou o desenvolvimento de novas abordagens. Pesquisas recentes têm se concentrado em métodos hormonais, que suprimem a espermatogênese através da manipulação hormonal, e métodos não-hormonais, que buscam alternativas inovadoras, como o bloqueio físico reversível dos canais deferentes e a inibição da motilidade espermática. Embora os métodos hormonais demonstrem potencial significativo, eles enfrentam desafios relacionados a efeitos colaterais, variabilidade na resposta individual e complexidade de adesão ao tratamento. Por outro lado, os métodos não-hormonais oferecem a promessa de evitar os riscos associados à manipulação hormonal sistêmica, mas ainda requerem validação em termos de segurança, reversibilidade e aceitação a longo prazo. Apesar dos avanços tecnológicos, desafios persistentes incluem a aceitação cultural, a minimização dos efeitos adversos e a necessidade de sistemas de entrega que sejam práticos e confiáveis. Este artigo revisa criticamente os desenvolvimentos recentes na contracepção masculina, destacando tanto as inovações quanto às barreiras que precisam ser superadas para que essas novas opções possam ser amplamente adotadas, promovendo uma maior igualdade na gestão da fertilidade e contribuindo para o planejamento familiar global.
O papel dos corticoesteroides como terapia adjuvante em pacientes com pneumocistose HIV-negativos
Authors: Da Mata Juliana Flávia Moura , Pessoa Silva de Bastos André , Rodrigues Gabriela Incerti de Paiva , Maehata Beatriz Yumi Asam , Almeida Aline Santos , Cantarelli Sofia Naves , Wilhelms Diene Landvoigt , Schuenck João Kleber Silva , Freitas Fabricio da Silva , Teófilo Rhuan Nantes Fontoura , Dossena Carolina , Moura Felipe Mota de , Bezerra Clovis de Medeiros
Published: September 2024

Introdução: A pneumocistose, uma infecção pulmonar oportunista grave é associada a grande mortalidade e é comum em pacientes com doenças oncológicas, como leucemias, linfomas, e tumores sólidos submetidos a quimioterapia, assim como em doenças hematológicas, como a aplasia medular e em pacientes submetidos a transplantes de medula óssea ou órgãos sólidos. O tratamento padrão da pneumocistose envolve a administração de trimetoprima-sulfametoxazol, possuindo opções alternativas como a pentamidina, a atovaquona, ou a clindamicina associada à primaquina, os quais podem ser associados a corticoesteroides, entretanto a eficácia de seu uso ainda é controversa.Metodologia: Foi realizada uma revisão integrativa nas bases de dados indexadas a Biblioteca Virtual da Saúde , usando como critério de inclusão artigos publicados no período de 2010 a 2024, nos idiomas inglês, disponíveis na integra e como critérios de exclusão, artigos duplicados, aqueles sem relação com o tema e revisões de literatura.Resultas e discussão: O uso de corticoesteroides junto ao antimicrobiano não reduziu a mortalidade em 30 e 90 dias após o diagnóstico, entretanto, foi capaz de reduzir o tempo de hospitalização em Unidades de Terapia Intensiva (UTI) e possibilitar melhora clínica mais rápida, traduzida em melhores controles de febre, dispneia e controle dos efeitos adversos das demais medicações, aparentando não apresentar maleficio para o paciente. Aqueles pacientes que já faziam o uso de corticosteroides antes do diagnóstico de pneumocistose com terapia imunossupressora também tiveram benefício do seu uso em doses anti-inflamatórias mais elevadas, entretanto, houve menor sobrevida.Conclusão: Os corticoesteroides podem ser utilizados como terapia adjuvante para pneumocistose pois apresentam benefícios, entretanto estes ainda não estão bem descritos na literatura.
EXPLORING INNOVATIONS IN SPORTS VENUE MANAGEMENT IN CHINA: BALANCING UTILIZATION AND SUSTAINABILITY
Authors: Jianhua Mei  , Wenjie Sun  , Kecun Chen
Published: September 2024

This paper explores innovative strategies for enhancing the utilization, financial sustainability, and community engagement of sports venues in China. As the industry faces challenges related to underutilization and economic viability, the study emphasizes the importance of multifunctional transformation and community-based operations. By reconfiguring sports venues to host a variety of events beyond traditional sports, operators can significantly increase utilization rates and revenue streams. The integration of digital and smart management technologies is identified as crucial for optimizing operational efficiency and enhancing the user experience. Additionally, the paper highlights the need for diversified revenue models, including retail services, corporate sponsorships, and digital content monetization, combined with sustainable development practices such as energy efficiency and waste reduction. These strategies not only secure the long-term financial health of sports venues but also align with broader environmental and social goals. The study concludes that sports venues adopting these innovative approaches will be better positioned to thrive in a competitive and evolving market landscape.
KEYWORDS：Sports Venue Management，Multifunctional Transformation，Community-Based Operations，Digital and Smart Technologies，Diversified Revenue Models，Sustainable Development
CSR EXPENDITURE AND ITS IMPACT ON FINANCIAL PERFORMANCE IN INDIAN PHARMACEUTICAL COMPANIES
Authors: Farhana Khatoon  , Dr Ranjit Kumar Paswan
Published: September 2024

This study intends to analyze the financial performance and the pattern of CSR spendings of selected pharmaceutical companies India. The study focuses on a set of seven BSE listed companies. Data has been meticulously gathered from published statements of selected companies covering a span of seven years from 2015-16 to 2021-22. The primary financial performance metric considered in the study is Return on Capital Employed (ROCE). To ascertain the association among CSR expenditure and firm performance, we applied correlation analysis. The findings of the study indicates that higher CSR expenditure is correlated to lower ROCE in Abbott India and Divi’s Laboratories.
KEYWORDS: Corporate Social Responsibility, CSR Expenditure, Financial Performance Pharmaceutical Companies.
Pengaruh Likuiditas Dan Leverage Terhadap Profitabilitas Pada PT. Gudang Garam Tbk (Tahun 2016 – 2020)
Authors: Dian Corrina , Dwi Erika , Khoirun Bella , Wahyu Yahya , Ermayanti Dwi
Published: September 2024

Penelitian ini berharap kepada mengecek resultan likuiditas dan leverage terhadap profitabilitas. Metode analisis yang digunakan adalah peraturan kuantitatif yang kedapatan tambah resam investigasi nonpartisipasi atau tidak langsung, khususnya tambah mengumpulkan, memaparkan dan meneliti bukti sekunder bercorak pengaduan pengaduan keuangan PT. Gudang Garam Tbk 2016 - 2020. Hasil pengecekan penyeragaman pengecekan Kolmogorov-Smirnov yang dilakukan memperlihatkan bahwa penyebab yang digunakan bagian dalam analisis berdistribusi dasar tambah periode persepsi 0,079 (lebih rancangan bersumber 0,05). Dalam unit ini, keuntungan PT Gudang Garam Tbk perian 2016 - 2020 dipengaruhi oleh konstituen likuiditas dan leverage.
Обґрунтування кадрового забезпечення в органах місцевого самоврядування
Authors: Малиновський Ю. В. , Карий О. І.
Published: September 2024

Розглянуто особливості кадрового забезпечення в органах місцевого самоврядування в сучасних умовах. Аргументовано, що кадрова політика є одним із основних засобів підвищення ефективності функціонування органів місцевого самоврядування. Обґрунтовано значення Закону України "Про службу в органах місцевого самоврядування" у процесі розмежування муніципальної та державної форм публічної служби. Наведено фактори, які негативно впливають на кадрову ситуацію, що склалася в системі органів місцевого самоврядування на сьогодні. Аргументовано потребу зміни принципу формування керівних кадрів в органах місцевого самоврядування за політичним критерієм на методи комплектації персоналу, засновані на принципі професіоналізму і компетентності в контексті радикальних змін кадрової політики у всіх сферах управлінської діяльності. Розглянуто сутність професіоналізму в аспекті кадрової політики в органах місцевого самоврядування, під яким треба розуміти не тільки володіння необхідним комплексом знань і навичок, а й вміння приймати обґрунтовані управлінські рішення. Наголошено, що для цього потрібно сформувати відкриту, демократичну, конкурентну систему формування кадрового потенціалу в органах місцевого самоврядування. Доведено потребу забезпечення стабільності кадрового складу в поєднанні з його цілеспрямованим оновленням як пріоритетний напрям формування кадрів в органах місцевого самоврядування. Пред'явлено логіку збереження та збагачення кадрового потенціалу органів місцевого самоврядування. Визначено, що пріоритетним напрямом під час формування кадрів в органах місцевого самоврядування є забезпечення стабільності кадрового складу в поєднанні з його цілеспрямованим оновленням. Подано пропозиції з удосконалення планування, добору та підготовки персоналу в органах місцевого самоврядування.
Стратегія диверсифікації діяльності як складова використання потенціалу підприємства на зовнішньому та внутрішньому ринках
Authors: Дідович І. І. , Атаманчук З. А. , Маліновська М. В. , Зюбрик Д. І.
Published: September 2024

Багато вітчизняних підприємств змушені переглянути свої стратегії, щоб впоратися з проблемами в Україні, які спричинило повномасштабне вторгнення Російської Федерації, що своєю чергою спонукає бізнес до виходу на нові ринки. Згідно з дослідженнями, які проводили у напрямку аналізу стану українського бізнесу в умовах військового стану, існують тенденції стосовно релокації підприємств не тільки всередині України, а й за її межами. Виходячи з цього, підприємства вимушені застосовувати у своїй діяльності диверсифікацію як одну із стратегій для підвищення ефективності діяльності на внутрішньому та зовнішньому ринках. Підприємства також можуть диверсифікуватися за результатами насиченості внутрішнього ринку та бажанням отримати прибутки від реалізації продукції за кордоном. У цьому дослідженні викладено та проаналізовано загальні засади формування стратегії диверсифікації з погляду використання потенціалу діяльності підприємства на різних ринках. Розглянуто сутність та особливості використання потенціалу та диверсифікації під час діяльності на внутрішньому та зовнішньому ринках. За результатами аналізу наукових публікацій виявлено недостатню кількість комплексних наукових досліджень стосовно формування та впровадження стратегії диверсифікації з погляду використання потенціалу діяльності фірми на внутрішньому та зовнішньому ринках. Особливу увагу сконцентровано на відмінних та спільних рисах впровадження стратегії диверсифікації з метою ефективного використання потенціалу у разі розширення присутності на внутрішньому ринку та виходу на зовнішній ринок. Зазначено, що, незалежно від ринку (внутрішнього чи зовнішнього), стратегія диверсифікації може допомогти розподілити ризики між різними напрямками діяльності, що дає змогу зменшити залежність від конкретного ринку чи товару/послуги і забезпечити більшу стійкість у разі змін у середовищі існування фірми.
Gold Investment Decisions to Anticipate Various Economic Problems in the Future (Study of Generation Z Mothers in Makassar City)
Authors: Msi Rustan
Published: September 2024

This type of qualitative research uses a phenomenological approach. The results of the research show that women, especially housewives, see the potential of gold as a very important investment, with the concept of understanding that gold investment cannot be separated from the risks and principles of benefits obtained, consistency in investment, gold that reliable, and following market developments. With awareness of the importance of gold investment and ongoing financial education, housewives can build a strong foundation for family financial stability, maintain peace of mind in the face of an uncertain future, and provide a solid foundation for future generations.
 
Received: 23 July 2024 / Accepted: 31 August 2024 / Published: 7 September 2024
Pelatihan Pengelolaan Gula Semut Di Nagori Silou Buttu Kecamatan Raya Kabupaten Simalungun
Authors: Purba Tioner , Ummu Harmain  , Simarmata Marulam MT , Triastuti
Published: September 2024

Brown sugar is crystallized palm sugar. Some of the reasons why palm sugar is healthier than granulated sugar is that the calories contained in palm sugar are smaller than white sugar so palm sugar is often referred to as low-calorie sugar, and palm sugar also has a lower glycemic index, namely of 35 while in granulated sugar the glycemic index is 58. The optimal way to improve the structure of melted sugar is by processing it into granular sugar, namely through re-melting of molded sugar with the addition of water into a sugar solution. The addition of granulated sugar and seed was found to have an effect on the yield, total sugar, sucrose, and the level of preference for color, taste and aroma, but decreased water content, reducing sugar, browning index and aroma level.The best treatment is the addition of 30% granulated sugar with a seeding temperature of 120 0C, in general it meets the requirements of SII where the water content, 2.75%, reducing sugar 4.35%, sucrose 81.14, total sugar 89.86, ash content, 1 .91%, browning index 0.20 abs/g and 81.36 yield. While the most preferred organoleptic test is the addition of 30% granulated sugar with a seeding temperature of 120 0C with a color value of 6.95, aroma 5.70 and taste 5.70. Economic analysis of melted molded sugar gives a profit of IDR 778,800/month, while improving the quality by processing ant sugar gives a profit of Rp. 1,606,000/month (all inputs are calculated at cost), If the allocation of family labor is categorized as family income plus the use of other materials that are not paid, then the income is Rp. 4,278,000/month for sugar. printing and Rp. 5,456,000/month for ant sugar. The processing of ant sugar is classified as a profitable business with a relatively higher price level than printed sugar
Sosialisasi Literasi Keuangan Bagi Anggota Paguyuban Pemandian Alam Sejuk (PAS) di Kabupaten Simalungun
Authors: Panjaitan Pawer Darasa , Damanik Darwin , Tumanggor Bagudek
Published: September 2024

The development of tourism in Simalungun Regency after the Covid 19 pandemic has started to get excited again, one of the attractions is the Pemandian Alam Sejuk (PAS) in Nagori Mariah Jambi. Paguyuban PAS is the manager of this tourist attraction. The development of this tourism object is still a lot of obstacles, one of which is fundamentally the problem of understanding financial literacy from Paguyuban PAS Members. This community service activity aims to provide understanding and education about the importance of financial literacy and good tourism management for Paguyuban PAS members. Based on the results of activities in the socialization of financial literacy and tourism management for Paguyuban PAS members, it can be concluded that the PAS Paguyuban members have low understanding of financial literacy, PAS Paguyuban members have low understanding in managing tourism objects properly, and the local government is not paying attention to providing infrastructure. and facilities around the PAS tourist area
EDUCATION AND ENTREPRENEURSHIP MOTIVATION: DO THEY INFLUENCE STUDENTS' ENTREPRENEURIAL INTEREST?
Authors: Endang Endang
Published: September 2024

AbstrackThis research aims to determine the influence of entrepreneurship education and entrepreneurial motivation on the entrepreneurial interest of class X students at SMA Negeri 2 Pangkep. The variables in this research are entrepreneurship education as the independent variable (X1), entrepreneurial motivation as the independent variable (X2) and interest in entrepreneurship as the dependent variable (Y). The population of this study was all class X students of SMA Negeri 2 Pangkep. The sampling technique uses the Total Sampling technique, samples from the population are obtained from the entire population with a sample of 72 students. Data collection techniques are questionnaires and documentation. The data analysis techniques used are Descriptive Statistical Analysis, instrument testing, classical assumption testing and hypothesis testing.The results of this research show that: (1) based on the results of descriptive statistical analysis, entrepreneurship education of 73.93 percent is in the high category, entrepreneurship motivation of 73.65 percent is in the high category, and entrepreneurship interest is 76.70 percent in the high category. tall. (2) Based on the multiple linear regression analysis carried out, the multiple linear regression equation Y = 1.108 + 0.760X1 + 0.586X2 is obtained, which means that for each additional value of entrepreneurship education there will be an increase of 0.760 and entrepreneurial motivation will increase by 0.586. (3) Based on the results of the f-test, the value of the entrepreneurship education variable is 546.119 > 0.235 with a significance level of 0.000 < 0.05. (4) Based on the results of the coefficient of determination (R2) for entrepreneurship education, the value obtained is (R2) = 0.281 or 28 percent. Meanwhile, the results of the coefficient of determination (R2) for entrepreneurial motivation obtained a value of (R2) = 0.47 or 47 percent. From the results of the coefficient of determination (R2), this means that the influence of entrepreneurship education on interest in entrepreneurship is 28 percent, while the influence of entrepreneurial motivation on interest in entrepreneurship is 47 percent. The remaining 25 percent is influenced by other factors that have not been studied. (5) Based on the t-test on the entrepreneurship education variable, a t value of 7,207 was obtained with a significance level of 0.000 < 0.05 and entrepreneurial motivation was a t value of 5,460 with a significance level of 0.000 < 0.05. Because both variables have a significant value that is smaller than alpha, namely 0.05, the hypothesis has a positive and significant effect on interest in entrepreneurship.Keywords: Entrepreneurship Education, Entrepreneurial Motivation, Entrepreneurial Interest
DEVELOPMENT OF POWTOON APPLICATION-BASED LEARNING MEDIA FOR XI IPS CLASS STUDENTS IN TUGUMULYO STATE HIGH SCHOOL
Authors: Adha Subali Rifqi Galih , Supriyanto Supriyanto , Susilo Agus
Published: September 2024

This study aims to develop and produce powtoon application-based history learning media that are valid, practical, and effective in learning History class XI IPS at SMA Negeri Tugumulyo. This research uses a Research and Development approach with the application of the ADDIE model. The research subjects consisted of 3 validation experts, 1 history subject teacher, and 34 students of XI IPS 2 class at SMA Negeri Tugumulyo. Data collection techniques included observation, interviews, questionnaires, tests, and documentation. The results of the expert assessment analysis showed that the powtoon application-based history learning media met the validity criteria, with a percentage of 86% linguist assessment, 92% material expert, and 77% media expert. In addition, the results of the practicality sheet assessment from teachers and students showed that the media also met the practical criteria, with an average practicality score of 88%. While the large group test shows that the learning media has high effectiveness, with an N-gain (g) value of 0.72, which is classified as high. Thus, it can be concluded that the powtoon application-based history learning media proved to be valid, practical, and effective in the context of History learning class XI IPS 2 at SMA Negeri Tugumulyo.
STUDENTS’ PROFILE ON ABILITY TO EXPLAIN BASIC CONCEPTS ON BIOLOGY OF THE CELL COURSE
Authors: Fernando Adam , Fauziah Nurul
Published: September 2024

The low quality of students' understanding of basic concepts in cell biology courses is reflected in the quality of students when explaining these concepts in class. Therefore, there was a need for information regarding student profiles to explain basic concepts of cell biology. This research aimed to describe the student's profile. This quantitative descriptive research involved 41 students from the UMRAH Biology Education Study Program who took the Cell Biology course in the odd semester of 2023-2024. This research used observation sheets to observe explanation skills. Based on the results and discussion obtained, the student profile regarding skills in explaining basic concepts of cell biology is in the less skilled category. Keywords: Ability; Explain; Concepts; Biology; Cell Abstrak Kualitas pemahaman mahasiswa yang rendah tentang konsep-konsep dasar pada mata kuliah biologi sel tercermin dari kualitas mahasiswa ketika menjelaskan konsep-konsep tersebut di dalam kelas. Oleh karena itu, perlu adanya informasi mengenai profil mahasiswa tentang keterampilan menjelaskan konsep-konsep dasar biologi sel. Penelitian ini bertujuan untuk mendeskripsikan profil mahasiswa tersebut. Penelitian deskriptif kuantitatif ini melibatkan mahasiswa Program Studi Pendidikan Biologi UMRAH yang mengikuti mata kuliah Biologi Sel di semester ganjil 2023-2024 sebanyak 41 orang. Penelitian ini menggunakan lembar observasi untuk mengamati keterampilan menjelaskan. Berdasarkan hasil dan pembahasan yang diperoleh, maka dapat disimpulkan bahwa profil mahasiswa tentang keterampilan menjelaskan konsep-konsep dasar biologi sel berada pada kategori kurang terampil. Kata Kunci: Keterampilan; Menjelaskan; Konsep; Biologi Sel
ANALYSIS OF LEARNING INTEREST ON BIOLOGY LEARNING OUTCOMES ON EXCRETORY SYSTEM MATERIAL IN SENIOR HIGH SCHOOL
Authors: Sirait Diana Khairiyah , Harahap Hasmi Syahputra , Machrizal Rusdi
Published: September 2024

Penelitian ini bertujuan untuk mengetahui minat belajar biologi pada materi sistem ekskresi kelas XI SMA Negeri 2 Rantau Selatan. Metode penelitian yang digunakan adalah kualitatif deskriptif dengan pendekatan ex-post facto dengan sampel penelitian sebanyak 64 murid yang di tentukan secara Cluster Random Sampling dengan rumus Taro Yamane. Instrumen penelitian menggunakan angket minat belajar dengan jumlah 25 pernyataan. Teknik analisis yang di gunakan dengan cara menghitung hasil angket berdasarkan skala likert. Hasil penelitian menunjukkan bahwa (1) Perolehan hasil nilai rata-rata minat belajar siswa kelas XI IPA sebesar 77,4%-89,4% menunjukkan minat belajar berkategori baik sampai sangat baik (2) Terdapat perolehan nilai indikator minat belajar yang signifikan di setiap kelas XI Ipa dengan nilai sebesar 74%-98% kategori baik sampai sangat baik. (3) perolehan minat belajar berdasarkan gender nilai siswi perempuan 84% > nilai siswa laki-laki 78%. Harapan ke depannya penelitian ini dapat menjadi bahan evaluasi solusi untuk lebih meningkatkan minat belajar siswa, diharapkan orang tua dan kepada guru untuk senantiasa berupaya memberikan pengawasan belajar baik di rumah maupun disekolah.
THE APPLICATION OF QUANTUM LEARNING MODEL TO IMPROVE THE LEARNING OUTCOMES OF IPS CLASS STUDENTS VIII IN SMP NEGERI 1 MUARA RUPIT
Authors: Pitri Andika Sari, Agus Susilo, Isbandiyah Pitri Andika Sari,
Published: September 2024

This study aims to determine the completion of social studies learning outcomes of class VIII students of SMP Negeri 1 Muara Rupit. The research method used is in the form of an experiment. The population is all class VIII students of SMP Negeri 1 Muara Rupit in the 2023/2024 academic year totaling 209 students and the research sample used is 1 class totaling 34 students. Data collection was carried out using the simple Random Sampling technique. The collected data were analyzed using a multiple-choice test totaling 30 questions. Based on the results of the data analysis, there was an increase in the average value in the Pre-test of 49.00 to 83.00 in the Post-test. The results of the post-test data analysis using the T test, the confidence level ɑ = 0.05 obtained tcount = 5.594 greater than ttable = 1.697, meaning that the hypothesis proposed in this study can be accepted as true because Ho is rejected and Ha is accepted for the results of social studies learning in class VIII students at SMP Negeri 1 Rupit.
Gambaran Morfologi Sel Neutrofil Pada Pewarnaan Giemsa dengan Variasi Waktu Pada Larutan Pengencer Akuades
Authors: Muflihah Ahdiah Imroatul , Destiawan Rian Anggia , Wijaya Anas Fadli , Widia Leny Yulia , Sufi Queen Nurul , Azizah Laila Camelia Nur , Makki Alisa Alfiya
Published: September 2024

Giemsa staining is a microscopic staining technique that aims to identify the morphology of leukocyte cell types. One of the methods that uses giemsa staining is the method of examining peripheral blood smear preparations which aims to evaluate the calculation of leukocyte type. The dyeing quality of giemsa is greatly influenced by the type of diluent material, namely buffer and aquadest. This study aims to determine the morphological picture of neutrophil cells in giema staining with time variations in aquadest diluent solution. The method of this study was to take blood from adults aged 20-25 years and had no history of illness as many as 24 samples. It was divided into 2 dilution groups, namely pH buffer 6.8 and aquadest, where each dilution was divided into 4 groups, namely group 1 soaking the peripheral blood smear preparation for 10 minutes, group 2 soaking the peripheral blood smear preparation for 20 minutes, group 3 soaking the peripheral blood smear preparation for 30 minutes, group 4 soaking the peripheral blood smear preparation for 40 minutes. Then a qualitative analysis was carried out, namely by comparing the background of the preparation and the morphology of neutrophil cells microscopically in each group. The results of this study are that microscopically groups 1 and 2 have a clear preparation background, while in groups 3 and 4 the preparation background is dirty and there are neutrophil granules and morphology in groups 1 and 2 show dark blue neutropnhil cells, groups 3 and 4 show purple and bluish-purple neutrophil cells. The conclusion of this study is based on the background of the preparation, and the morphology of neutrophil cells, the group that has the best results is groups 1 and 2.
Key words : Aquadest, eosinophil cells, eutrophil cells, Giemsa staining
Gambaran Hasil Procalcitonin dan D-Dimer Pada Pasien Covid-19 Di RSUD Budhi Asih Jakarta Timur
Authors: Permata Kamilia Gulin , Nurdiani Catu Umirestu , Nugroho Heru Purwanto , Susanti Ellis
Published: September 2024

The World Health Organization (WHO) declared an epidemic caused by Coronavirus Disease – 19 (Covid-19) on January 9, 2020. The first case was found on December 30, 2019 in Wuhan, China. The virus spreads through droplets. Symptoms of COVID-19 start from shortness of breath, cough and fever. Patients who are confirmed with COVID-19 are then carried out laboratory tests in the form of Procalcitonin (PCT) and D-dimer. This study was conducted using a descriptive method whose data was taken from laboratory examination results for the period April 2022 - May 2023 as many as 54 PCT and D-dimer result data. The results of the frequency distribution examination were based on normal values, normal PCT levels as many as 24 patients (44%) and abnormal PCT levels as many as 30 patients (56%) and normal D-dimer levels as many as 23 patients (43%) and abnormal D-dimer levels as many as 31 patients (57%). The frequency distribution in COVID-19 patients based on gender, male as many as 28 patients (52%) while in women as many as 26 patients (48%).In this conclusion, the frequency distribution of PCT and D-dimer examinations based on gender, men are higher than women. PCT examination is more with abnormal values compared to normal values. D-dimer test results with abnormal values more than normal values.
Keyword            : Covid-19, D-dimer, PCT
Pengaruh Ekstrak Etanol Daun Sirih Merah (Piper crocatum) Terhadap Kadar Gula Darah Tikus Putih (Rattus norvegicus)
Authors: Sapalma Krisma Winditia , Ahmad Tasrif
Published: September 2024

Red betel leaf is a medicinal plant that contains several active ingredients that are beneficial for health. One of the active ingredients in red betelleaves is flavonoids such as quercetin. Quercetin is a flavonoid compound which is found in many plants and has anti-diabetic properties to reduce blood sugar levels in the body. The aim of this research was to determine the effect of administering red betel leaf extract (Piper crocatum) on the blood sugar levels of rats (Rattus novergicus). This research was an analytical experimental research with pretest and posttest. The division of control and treatment groups used Simple Random Sampling sampling techniques. There were 4 groups, namely control, treatment 50 mg/kgBB, 100 mg/kgBB, and 200 mg/kgBB. Treatment was given for 21 days and then blood sugar levels were measured using a Clima MC 15 photometer. Research data was analyzed using the One Way ANOVA Test with SPSS. The results of the Shapiro-Wilk normality test were obtained with a value of sig>0.05; Levene Test homogeneity test with sig. value > 0.05; One Way ANOVA with a sig value <0.05. It can be concluded that there is a real effect on the blood levels of white rats (Rattus norvegicus) after administering ethanol extract of red betel leaves (Piper crocatum) at doses of 50 mg/kgBB, 100 mg/kgBB, and 200 mg/kgBB. kgBB.
Key words: Diabetes mellitus, Ethanol Extract of Red Betel Leaves (Piper crocatum), White Rat (Rattus norvegicus)
Health Education dan Early Detection Kesehatan Mata Pada Santri di Pondok Pesantren Al-Hidayah Bogor
Authors: Ardhiyanti Lusyta Puri
Published: September 2024

ABSTRAKPada era digital di mana perkembangan teknologi semakin pesat seperti saat ini, penggunaan gawai semakin tak bisa dihindari. Kehadiran gawai kini terasa begitu vital. Mulai dari kebutuhan komunikasi, menghimpun informasi, dokumentasi, transaksi, transportasi, sampai dengan kebutuhan rekreasi dapat terpenuhi lewat satu buah gawai. Permasalahan yang didapatkan di Pondok Pesantren Al hidayah bogor adalah Radang mata pernah dialami oleh santri Pondok Pesantren al hidayah bogor akibat terlalu lama memandang gawai. Tidak mau mengulang ada gangguan mata yang dialami oleh santri, Pondok Pesantren Al hidayah bogor memperketat pengawasan terhadap kegiatan online.Tujuan kegiatan pegabdian kepada masyarakat yaitu meningkatkan pengetahuan serta pemahaman santri tentang Kesehatan mata melalui kegiatan edukasi kesehatan mata dan deteksi dini gangguan mata pada santri di Pondok Pesantren Alhidayah bogor. Metode pengabdian dengan memberikan edukasi tentang pentingnya menjaga kesehatan mata dan deteksi dini gangguan mata. Hasil pengabdian menunjukkan bahwa terdapat peningkatan pengetahuan santri tentang Kesehatan mata .Kata Kunci:Edukasi,Kesehatan mata,Deteksi dini.
Kelas Gizi: Edukasi Dampak Perilaku Makan Terhadap Status Gizi Dan Kesehatan Pada Remaja Di SMAN 2 Cileungsi
Authors: Wandini Kartika - , Mardiah Sarah , Dwiyana Parlin
Published: September 2024

Masa remaja adalah periode emas kedua dalam tumbuh kembang seseorang setelah melewati masa balita, karenaitu kecukupan nutrisi wajib terpenuhi. Pemenuhan nutrisi remaja tentu diperoleh dari asupan makanan bergizi. Namun, beberapa penelitian menunjukkan bahwa remaja saat ini memiliki permasalahan dalam perilaku makan.Untuk itu, edukasi diperlukan guna memberi pengetahuan dan pemahaman pada remaja pentingnya memiliki perilaku makan yang baik agar dapat mengoptimalkan periode tumbuh kembangnya. Tujuan kegiatan adalah meningkatkan pengetahuan remaja di SMAN 2 Cileungsi, Kabupaten Bogor mengenai dampak perilaku makan terhadap status gizi dan kesehatan. Program edukasi dilaksanakan di SMAN 2 Cileungsi, Kabupaten Bogor, pada bulan September 2023 dengan empat tahap kegiatan yakni, perencanaan, perizinan, pelaksanaan termasuk pre-test dan post-test, dan evaluasi. hasil pretest menunjukkan, perilaku makan remaja perlu diperbaiki. Sebagian besar remaja jarang untuk sarapan pagi dan mengonsumsi buah dan sayur, namun sering mengonsumsi makanan cepat saji, teh dan kopi serta minuman ringan. Hasil pre test pengetahuan menunjukan skor rata-rata remaja adalah 70.5, sementara hasil post test menunjukkan skor rata-rata pengetahuan 73. Terjadi peningkatan skor sebesar 2.5 poin. Peningkatan skor saja tidak cukup, untuk itu diperlukan adanya edukasi yang berkelanjutan agar remaja semakin memahami dan dapat menyadari pentingnya memiliki perilaku makan yang baik.Kata kunci: Remaja, Perilaku Makan, Pengetahuan, Kelas Edukasi
Pelatihan Pengenalan Web Dasar pada Siswa/Siswi Madrasah Aliyah Negeri (MAN) 6 Kampung Dukuh Jakarta Timur
Authors: Setiadi Dedi , Widodo Yohanes Bowo , Narji Mohammad , Agustino Rano , Sibuea Sondang , Saputro Mohammad Ikhsan , Julfia Fenty Tristanti
Published: September 2024

Pengenalan web dasar menjadi keterampilan yang semakin penting dalam era digital saat ini. Perlu dilakukan kegiatan pengabdian kepada masyarakat berupa pelatihan pengenalan web dasar yang diselenggarakan untuk siswa/siswi Madrasah Aliyah Negeri (MAN) 6 Kampung Dukuh Jakarta Timur. Tujuan dari kegiatan ini adalah untuk memberikan pengetahuan dan keterampilan dasar dalam mengoperasikan dan memahami konsep-konsep dasar web kepada siswa/siswi MAN 6, sehingga mereka dapat lebih mandiri dalam memanfaatkan teknologi informasi. Metode yang digunakan dalam pelatihan ini meliputi ceramah interaktif, demonstrasi praktis, serta sesi tanya jawab untuk memastikan pemahaman yang baik dari materi yang disampaikan. Ditemukan bahwa peserta pelatihan menunjukkan minat yang tinggi dalam mempelajari materi, dan keterampilan mereka dalam navigasi web serta menggunakan aplikasi web meningkat secara signifikan. Hasil dari kegiatan ini menunjukkan peningkatan pemahaman siswa/siswi MAN 6 terhadap konsep-konsep dasar web serta kemampuan mereka dalam menggunakan berbagai fitur dasar web. Implikasi dari kegiatan ini adalah penguatan kemampuan siswa/siswi MAN 6 dalam menghadapi tantangan era digital dan peningkatan keterampilan mereka dalam memanfaatkan teknologi informasi untuk kepentingan pribadi dan akademik. Diharapkan bahwa kegiatan serupa dapat diperluas untuk melibatkan lebih banyak siswa/siswi serta sekolah lainnya, sehingga manfaatnya dapat dirasakan secara lebih luas dalam masyarakat.
Pelatihan Pembuatan Game Menggunakan Unity Untuk Siswa/I SMK Brahari
Authors: Afriantoro Irfan , Suherman  , Nurul Arifaeni Islami  , Edi Widodo  , Rensi Suryanti  , Puji Harta
Published: September 2024

Abstrak: Pengabdian Masyarakat ini mengangkat kegiatan mengenai pelatihan pembuatan Game menggunakan Game Engine Unity. Unity merupakan salah satu Game Engine terpopuler saat ini. Dikarenakan game engine ini mampu untuk menghasilkan game lintas platform sistem operasi. PKM ini diadakan bersama siswa SMK BRAHARI Kabupaten Bekasi. Kegiatan ini di adakan di SMK BRAHARI Kabupaten Bekasi. Dari kegiatan ini peserta diajarkan step-step pembuatan aplikasi menggunakan unity. Peserta diajarkan teknik instalasi, pembuatan objek dasar dan game dasar. Evaluasi kegiatan berupa beberapa tugas latihan dari pemateri yang dikumpulkan di kemudian hari. Tugas ini dikerjakan disekolah mereka masing-masing. Hasil dari penghargaan peserta ini diberikan berupa sertifikat kepada masing-masing peserta. Hasil pekerjaan projek terbaik diberikan hadiah tambahan dari pemateri.
 
Kata Kunci : Aplikasi, Game, Pelatihan, SMK, Unity.
 
Abstract: This Community Service raises activities regarding game making training using Game Engine Unity. Unity is one of the most popular Game Engines today. Because this game engine is capable of producing cross-platform games for operating systems. This PKM was held with students of SMK BRAHARI Kabupaten Bekasi. This activity was held at the Faculty of Computer Science, Lancang Kuning University. From this activity, participants were taught the steps for making applications using Unity. Participants are taught installation techniques, basic object creation and basic games. Evaluation of activities in the form of several exercise assignments from the presenters who were collected at a later date. This task is done in their respective schools. The results of this participant award are given in the form of a certificate to each participant. The best project work is given additional prizes from the presenters.
 
Keywords: Applications, Games, Training, Vocational High School, Unity.
Inovasi Pengelolaan Sampah: Tempat Sampah Pintar Berbasis IoT di Museum MH.Thamrin Jakarta
Authors: Agustino Rano , Saputro Moh Ikhsan , Gustiawan Handa , Sakaria M Amin , Widyahastuti Febrianti
Published: September 2024

Kotak sampah pintar dengan sistem deteksi otomatis hadir sebagai solusi inovatif untuk mengatasi permasalahan penumpukan sampah dan pengambilan sampah yang tidak teratur di Museum. Kotak sampah ini dilengkapi sensor ultrasonik dan mikrokontroler untuk mendeteksi tingkat pengisian dan mengirimkan notifikasi kepada petugas kebersihan ketika sampah hampir penuh. Hal ini memungkinkan pengumpulan sampah yang tepat waktu dan efisien, meminimalisir penumpukan sampah, dan meningkatkan kebersihan lingkungan. Penelitian ini merancang dan membangun purwarupa kotak sampah pintar dengan harapan dapat meningkatkan efisiensi pengelolaan sampah di Museum, mendorong terciptanya lingkungan yang lebih bersih dan sehat, serta menjadi langkah awal menuju pengelolaan sampah yang berkelanjutan dan ramah lingkungan. Penerapan kotak sampah pintar ini diharapkan dapat mengurangi penumpukan sampah, meningkatkan efisiensi pengumpulan sampah, dan mendorong partisipasi pengunjung dalam menjaga kebersihan lingkungan, sehingga Museum menjadi tempat yang lebih nyaman dan menyenangkan bagi semua orang.Kata Kunci: Kotak Sampah IoT, Mikrokontroler, Sensor ultrasonik, WeMos
Penggunaan Software Nginx Sebagai Load Balancing Web Server Clustering
Authors: Sibuea Sondang , Widodo Yohanes Bowo , Khaliq Muhammad Nur
Published: September 2024

Ketika suatu situs web mengalami tingkat kunjungan yang tinggi, berdampak peningkatan permintaan layanan pada server web tunggal. Akibatnya, kinerja server web menjadi terbebani dan kemungkinan terjadi overload, sehingga server tunggal tidak mampu melayani semua permintaan dari pengguna. Untuk mengatasi hal tersebut, dapat dilakukan sistem cluster dan metode load balancing pada server. Dalam sistem cluster, beberapa server dapat dikombinasikan. Permintaan dari pengguna dapat dibagi secara merata ke seluruh cluster server web. Untuk melakukan cluster pada server, digunakan software nginx sebagai metode untuk membagi tugas yang diberikan oleh pengguna kepada cluster server web. Dengan menerapkan cluster server web dan metode load balancing sebagai pembagi, kinerja layanan kepada pengguna dapat dipercepat dibandingkan dengan hanya menggunakan satu server web. Jika terjadi kegagalan pada perangkat keras yang mengakibatkan matinya server secara keseluruhan, server lain dalam cluster akan mengambil alih fungsi server yang mati. Dengan demikian, komputer klien tidak menyadari adanya kegagalan pada server, karena proses yang sedang berlangsung pada server yang gagal atau mati akan dilanjutkan oleh server cadangan. Setelah dilakukan pengujian, dapat diambil kesimpulam bahwa dengan menggunakan load balancing bisa dimanfaatkan sebagai backup        atau failover,  jika salah satu server down dapat diatasi oleh server lainnya. Pelayanan request data dari user dapat ditangani lebih cepat. Rekomendasi yang dapat diberikan guna pengembangan lebih lanjut maupun melengkapi penelitian ini, yaitu dengan  melakukan load balancing pada database server cluster.
STUDY OF THE EFFICIENCY OF THE FUNCTIONING PROCESS OF THE MECHATRONIC SYSTEM OF ENSURING THE MICROCLIMATE OF ANIMAL PREMISES
Authors: YAROPUD Vitalii
Published: September 2024

The development of the livestock industry is the basis of Ukraine's food security. One of the ways to solve this problem is to improve the conditions of keeping animals, including improving the microclimate of livestock and poultry premises. Modern animal husbandry technologies make high demands on the microclimate in livestock premises. According to scientists, animal husbandry specialists and technologists, animal productivity is determined by 50...60% feed, 15...20% by care, and 10...30% by the microclimate in the livestock premises. Deviation of the microclimate parameters from the established optimal limits leads to a decrease in milk yield by 10...20%, an increase in live weight – by 20...35%, an increase in the departure of young animals to 5...40%, and a decrease in laying hens – by 30%...35%, costs of an additional amount of feed, shortening the service life of equipment, machines and the buildings themselves, reducing the resistance of animals to diseases, negatively affecting the service personnel.
The article presents a structural and technological scheme of a mechatronic system for ensuring a normative microclimate of livestock premises, which allows to increase the efficiency of ensuring a normative microclimate of livestock premises by using a mechatronic system for controlling the process of air disinfection using ultraviolet radiation of bactericidal lamps. According to the results of numerical modeling of the air heat exchanger of the indirect-evaporative type, the distribution of the temperature field, vector field of velocities and absolute air humidity in channels of different shapes (square, equilateral triangle, circle) was established. The calculated coefficient of thermal efficiency of the heat exchanger with triangular shaped channels is the whitest in contrast to square and round shapes. A comparative analysis of humidity distribution in channels of different shapes confirms that the absolute humidity of the thermal air flow decreases earlier in the indirect-evaporative type heat exchanger with triangular channels.
Can we use superglues for superfi cial lacerations?
Authors:   Hasan KAYA1, Cem OKTAY2*, Ciler CELIK-OZENCI3, Nazli Ece GUNGORORDUERI4, Nilay KUSCU3, Omer OZKAN5, OKTAY Cem
Published: September 2024

Objectives: To compare the histopathological and cosmetic outcomes of ethyl-cyanoacrylate to n-butyl-2-cyanoacrylate in rats using an incision wound model. Methods: Two longitudinal incisions were made on the dorsal region of the back of 18 Wistar rats after ketamine anesthesia. Rats were divided into three groups of six: the incisions were closed either using medical tissue adhesive or superglue or were left for secondary wound healing. In each group, three rats were randomly euthanized on the 7th day. The rest were euthanized on the 21st day of the procedure. Tissue samples taken on days 7 and 21 were Histopathologically evaluated blindly by a histologist. The cosmetic appearance was evaluated by a plastic surgeon blinded to the method of closure using a visual analog scale. Results: Histopathological evaluation revealed impaired epithelialization, infl ammation, fi brosis, and dehiscence on connective tissue, and foreign substance reactions were worse in the ethyl-2-cyanoacrylate group when compared with the other groups. A statistically signifi cant diff erence was not found among groups regarding the cosmetic outcome. Conclusions: Cyanoacrylate glues produced for commercial purposes should not be used for the repair of skin lacerations due to their worse histopathological results of epithelialization, infl ammation, fi brosis, dehiscence on connective tissue, and foreign substance reaction. Keywords: Lacerations, Wound closure techniques, Tissue adhesives, Cyanoacrylates, Wound healing.
Identificación de indicadores para medir la polarización del personal científico en universidades públicas de Bolivia
Authors: Caballero Calle Edwin Ebert
Published: September 2024

El estudio presenta una propuesta de indicadores para evaluar el nivel de polarización del personal científico en las universidades públicas de Bolivia, identificando la polarización como un obstáculo significativo para la colaboración y la generación de conocimiento. Fundamentado en teorías de gestión del conocimiento y desarrollo organizacional, se subraya la importancia de un ambiente favorable para la innovación y la cooperación. La investigación se basa en la formulación de indicadores específicos en diversas dimensiones como la ideología política, los conflictos interpersonales, y la colaboración en equipos de investigación. La metodología incluye la creación de una encuesta para recopilar datos y medir estos factores. El estudio concluye que la polarización afecta negativamente la colaboración y la innovación, proponiendo estrategias para mitigar estos efectos y promover un ambiente de trabajo más colaborativo y productivo.
Escuelas normales y formación inicial: una trama social, histórica y compleja
Authors: Hernández Aragón Magaly
Published: September 2024

La formación inicial del profesorado normalista en México y, en gran parte del mundo, se ha constituido como uno de los temas más recurrentes en el campo de la investigación educativa. El análisis y comprensión de su constitución y desarrollo, demanda situarla como un constructo social, histórico, cultural y político. En este sentido, en el presente texto se desarrolla una mirada relacional histórica entre la articulación de las escuelas normales, la profesión docente y la formación inicial. A partir de ello, se subraya los cambios experimentados en la configuración de la formación del docente normalista mexicano, en función del mismo devenir social e histórico, pero también de los posicionamientos ideológicos que abandera cada gobierno, de los intereses económico-políticos, así como de las mismas exigencias internacionales; por lo tanto, se evidencia las relaciones de poder que se entrecruzan para dar forma y contenido a los procesos formativos del profesorado normalista.
Successful implementation of interchange of biologic medications in chronic arthritis after information of costs to prescribers
Authors: Perez-Ruiz Fernando , Garmendia-Sanchez Elena , Arostegui-Lavilla Javier , Duruelo-Echevarrieta Javier , Atxotegi-Saenz de Buruaga Joana , Rivas-Zavaleta Mayra Nathali , Casas-Arrate Javier , del Consuelo Modesto-Caballero Maria , de Basagoiti-Gorordo Amaya
Published: September 2024

Aim: To evaluate the impact of prescription, cost, and switching policy on the rate of switching from reference products to biosimilars.
Methods: Analysis of an administrative database for prescription in a rheumatology division. Biosimilars for adalimumab and etanercept were available in 2019. Blinded costs and prescription data were not shared with prescribing physicians until 2021. The rate of prescription, persistence of therapy after switching, and reduction of cost were analyzed from 2019 to 2022. A new etanercept biosimilar was prioritized in 2022, and a new switching wave from biosimilar to biosimilar etanercept was implemented.
Results: Overall switching from 2019 to 2022 comprised 132/135 (97.8%) of patients. The rate of switching increased from 13.3% to 34%, 79%, and 95.5% of patients on reference products during 2019, 2020, 2021, and 2022, respectively. In 2022, after sharing information, the switch comprised 55/135 (40.7%) of overall switching. The rate of persistence on therapy after switching was 86.8% for etanercept and 79.7 for adalimumab. During 2023, a rate of 76.6% switching etanercept reference-biosimilar-biosimilar was achieved. The reduction in the overall biologic budget in 2021 was 19.2% and 29.0% for the patient-year cost.
Conclusions: Information to prescribers may improve switching policies. Persistence on biosimilar medications after switching is as high as previously reported.