bluuebunny/crossref_metadata_2025 huggingface dataset:
Regular cannabis use modulates gamma activity in brain regions serving motor control
Authors: Webert Lauren K , Schantell Mikki , John Jason A , Coutant Anna T , Okelberry Hannah J , Horne Lucy K , Sandal Megan E , Mansouri Amirsalar , Wilson Tony W
Published: August 2024

Background:

People who regularly use cannabis exhibit altered brain dynamics during cognitive control tasks, though the impact of regular cannabis use on the neural dynamics serving motor control remains less understood.

Aims:

We sought to investigate how regular cannabis use modulates the neural dynamics serving motor control.

Methods:

Thirty-four people who regularly use cannabis (cannabis+) and 33 nonusers (cannabis−) underwent structured interviews about their substance use history and performed the Eriksen flanker task to map the neural dynamics serving motor control during high-density magnetoencephalography (MEG). The resulting neural data were transformed into the time–frequency domain to examine oscillatory activity and were imaged using a beamforming approach.

Results:

MEG sensor-level analyses revealed robust beta (16–24 Hz) and gamma oscillations (66–74 Hz) during motor planning and execution, which were imaged using a beamformer. Both responses peaked in the left primary motor cortex and voxel time series were extracted to evaluate the spontaneous and oscillatory dynamics. Our key findings indicated that the cannabis+ group exhibited weaker spontaneous gamma activity in the left primary motor cortex relative to the cannabis− group, which scaled with cannabis use and behavioral metrics. Interestingly, regular cannabis use was not associated with differences in oscillatory beta and gamma activity, and there were no group differences in spontaneous beta activity.

Conclusions:

Our findings suggest that regular cannabis use is associated with suppressed spontaneous gamma activity in the left primary motor cortex, which scales with the degree of cannabis use disorder symptomatology and is coupled to behavioral task performance.
Rosettes and pseudorosettes in veterinary neuropathology
Authors: Rissi Daniel R. , Miller Andrew D.
Published: August 2024

Rosettes and pseudorosettes are morphologic cell arrangements found in many neuroepithelial neoplasms in human medicine, including embryonal nervous system tumors (neuroblastoma, medulloblastoma, pineoblastoma, and retinoblastoma), non-embryonal nervous system tumors (ependymoma, astrocytoma, oligodendroglioma, and choroid plexus tumors), and other extraneural neuroepithelial neoplasms. Although these structures are also described in neuroepithelial neoplasms of domestic animals, their frequency is still poorly characterized or inconsistently documented in veterinary medicine. Furthermore, rosettes and pseudorosettes need to be interpreted with caution and within a clinical and pathologic context and should not be solely relied upon for diagnostic confirmation of a particular neoplasm. Here, we review the morphologic features and frequency of the most common types of rosettes and pseudorosettes described in neuroepithelial neoplasms of domestic animals, focusing primarily on those occurring in the nervous system and closely associated tissues.
Supply chain integration capability: A three-stage circular model of visibility, agility, and flexibility
Authors: Wang Michael , Wang Bill , Kim Namwoon , Chan Ricky , Wang Mengmeng , Shi Yangyan
Published: August 2024

This paper presents supply chain capabilities in a three-stage circular model. Different from most studies exploring supply chain integration (SCI) from the perspective of processes, this paper studies SCI from a holistic approach. By applying dynamic capability view (DCV), this study develops a measurement of SCI capability based on the three-stage circular model. The scale items were drawn from existing literature. A survey study gathered 187 responses from firms in New Zealand. Factor analysis was conducted to validate the measurement of supply chain integration in the New Zealand businesses. The paper defines the SCI capability as a second-order construct including several well-studied dynamic capabilities such as visibility, agility, and flexibility. The three-stage circular model enables firms to learn, response, and reconfigure to achieve rapid continuous improvement in supply chains. This paper provides new insights and practical implications in SCI and supply chain capability studies and practices in the Industry 4.0 era.
Is foster caring associated with an earlier transition to adulthood for caregivers’ own children? ONS Longitudinal Study
Authors: Sacker Amanda , Lacey Rebecca , Maughan Barbara , Murray Emily
Published: August 2024

This study investigates whether existing children in a fostering household differ from young people in non-caregiving households in the timing of their transitions to key adult roles, which are known to affect later health and life chances. Using data from the ONS Longitudinal Study, we pooled records from census years 1971–2001 and linked them to follow-up records from 1981–2011. We identified 2,656 children living with a foster child and compared their profiles on the ‘big five’ transitions to roles of adulthood – finishing school, leaving home, finding work and becoming financially independent, getting married, and having children – with those of other children without a foster child in the household (N = 209,453). We fitted logistic and multinomial models that controlled for childhood socioeconomic and demographic confounders to estimate the proportion achieving the five roles in early adulthood. When compared to those without a foster child in the household, a modest but reliably higher proportion of caregivers’ children achieved the transition to adulthood. There was some evidence that caregivers’ children might cope better with the transition to adulthood if they were older than the foster child or were female. The findings suggest that supporting foster parents with delaying their children’s transition to adulthood could become part of the role of supervising social workers.
(Dis)connected parenting: Context control and information management in single adoptive parents’ social media practice
Authors: Mackenzie Jai
Published: August 2024

Drawing on grounded theory research with parents who brought children into their lives in non-traditional ways, this article considers how three UK-based single adoptive parents navigate a complex set of risks, benefits and limitations as they construct mutually beneficial connections, friendships and support networks online. The discussion draws on media scholarship suggesting that, in response to contemporary norms of constant connection, digital availability and online context ‘collapse’, many internet users appropriate the affordances of online platforms and technologies to maintain personal boundaries and keep social groups apart. I argue that such tight context control can be particularly important for single adoptive parents, whose children are often vulnerable in multiple ways, who continue to face social stigma and misunderstanding, and for whom privacy can be vital to their families’ safety and wellbeing. The article pays particular attention to single adopters’ strategic deployment of three interconnected practices for managing and curating their networks and information sharing: compartmentalisation, selective sharing and disengagement. As well as pointing to similarities between participants’ practices, the article considers how the nuances of their individual circumstances shape and influence their ways of both connecting with, and disconnecting from, a range of individuals, groups and networks.
Multi-functional hybrid sandwich composite structures: Evaluating damage mechanics and tolerance using compression after impacts
Authors: Iqbal Zafar , Umer Malik Adeel , Khan Haris Ali , Asim Kamran
Published: August 2024

Building upon previous researches that introduced an innovative foam core hybrid-sandwich composite structure for radome applications, showcasing promising performance under low-velocity impacts (LVIs), this paper delves into the assessment of damage tolerance and mechanics through Compression After Impact (CAI) testing. The primary objective is to analyze disparities in damage tolerance, damage mechanisms, displacements, deformations, energy absorption, and residual strengths resulting from LVIs followed by CAIs on dissimilar materials on opposite faces of the hybrid structure. The extent of damage is evaluated through Computed Tomography (CT) scans. During LVIs, impacts on the S glass face sheets side demonstrated different energy dispersion and absorption mechanisms, leading to variations in indent damage depths and widths across all impact energy levels, unlike the impact damages observed from the Kevlar side. During CAI testing, this difference becomes more evident, with Kevlar specimens (KS3 & KS5) showing greater indentation depths and narrower widths, and S glass specimens (SK3 & SK5) experiencing buckling. These effects are due to the unique damage absorption and dispersion properties of Kevlar and S glass. These variations prompted an in-depth investigation of the structure using CAI to comprehend damage tolerance and mechanisms under compressive loads. This study, unparalleled in existing literature, proposes hybrid sandwich structures with superior specific impact and residual strength compared to various composite sandwich structures documented in published literature, expanding their utility beyond radomes.
“I feel like a caged pig in here”: Language, Race, and Ethnic Identity in a Case Study Hmong Nursing Home Resident Quality of Life
Authors: Thao Mai See , Davila Heather , Shippee Tetyana
Published: August 2024

Racial disparities in nursing home (NH) quality of life (QOL) are well established, yet, little is understood about actual experiences shaping QOL for Black, indigenous, and people of color (BIPOC) residents in NHs. This gap extends to BIPOC residents with limited English proficiency (LEP). Drawing on Kane’s (2001) and Zubristky’s (2013) QOL frameworks, this case study examined QOL experiences for Hmong NH residents, an ethnic and refugee group from Southeast Asia, in a NH with a high proportion of BIPOC residents. Methods include four months of observation, interviews with eight Hmong residents and five NH staff, and one community focus group. Thematic analysis revealed significant challenges in QOL. Exacerbated by language barriers and racism, many residents reported neglect, limited relationships, lack of meaningful activities, and dissatisfaction with food. These experiences fostered a sense of resignation and diminished QOL among Hmong residents, highlighting the need for additional supports for this group.
Advancing Diversity, Equity, and Inclusion in School Psychology Science and Scholarship: Changing Training and Practice in the Field of School Psychology
Authors: Jimerson Shane R. , Allen Justin P. , Arora Prerna , Blake Jamilia J. , Canivez Gary L. , Chambers Caitlyn , Chan Meiki , Espelage Dorothy L. , Gonzalez Jorge E. , Gormley Matthew , Graves Scott L. , Holland Shemiyah , Huang Francis L. , January Stacy-Ann A. , Kaur Lakhvir , Kyung Kim Eui , LaSalle Tamika , Mittelstet Alessandra , Phelps Chavez , Reinke Amber , Renshaw Tyler L. , Song Samuel Y. , Sullivan Amanda L. , Wang Cixin , Worrell Frank C. , Yang Chunyan
Published: August 2024

The intentional and sustained actions to advance diversity, equity, and inclusion (DEI) in school psychology science and scholarship, will have reciprocal and dynamic influences on graduate preparation and practice. Herein, the School Psychology Review leadership team provides reflections on several of our intentional efforts, to date, to advocate for and advance DEI in school psychology scholarship, and the associated implications for graduate preparation and practice. Contemporary actions of the School Psychology Review leadership team have included; (a) establishing commitments to advocating for and advancing DEI as the foundation of our scholarship; (b) diversifying journal leadership and editorial board members to reflect the diverse student body school psychologists serve; (c) preparing future diverse journal leadership through mentored editorial fellowship programs, and a student editorial board with members from diverse backgrounds; (d) featuring special topics relevant to further understanding and supporting diverse and minoritized children, youth, families, and school communities; (e) providing professional-development opportunities and resources; (f) implementation of Open Science opportunities in the journal, (g) implementing triple anonymous peer review to reduce bias, and (h) implementing a journal action plan focused on advancing DEI. Collectively these efforts are aimed to influence positive change in advancing and sustaining DEI efforts in school psychology science, scholarship, graduate preparation and practice.
Venoarterial Extracorporeal Membrane Oxygenation Therapy in Patients with Sickle Cell Disease: Case Series and Review for Intensive Care Physicians
Authors: Grazioli Alison , Rabin Joseph , Rector Raymond P. , Wu Zhongjun J. , Burke Allen P. , Sharifai Nima , Shah Aakash , Taylor Bradley S. , Gladwin Mark T.
Published: August 2024

Sickle cell disease (SCD) is associated with substantial morbidity and early mortality in afflicted adults. Cardiopulmonary complications that occur at increased frequency in SCD such as pulmonary embolism, pulmonary arterial hypertension, and acute chest syndrome can acutely worsen right ventricular function and lead to cardiogenic shock. Mechanical circulatory support including venoarterial extracorporeal membrane oxygenation (VA ECMO) is being increasingly utilized to treat hemodynamic collapse in various patient populations. However, a paucity of literature exists to guide the use of mechanical circulatory support in adults with SCD where disease-related sequela and unique hematologic aspects of this disorder may complicate extracorporeal therapy and must be understood. Here, we review the literature and describe three cases of adult patients with SCD who developed cardiogenic shock from acute decompensated right heart failure and were treated clinically with VA ECMO. Using an in vitro ECMO system, we investigate a potential increased risk of systemic fat emboli in patients with SCD who may be experiencing vaso-occlusive events with bone marrow involvement given the high-volume shunting of blood from venous to arterial systems with VA ECMO. The purpose of this study is to describe available extracorporeal life support experiences, review potential complications, and discuss the special considerations needed to further our understanding of the utility of VA ECMO in those with SCD.
Food Shopping Strategies Among a Diverse Sample of East Harlem Residents: A Qualitative Study
Authors: Nieves Christina , Dannefer Rachel , Sacks Rachel , Zamula Arlen
Published: August 2024

Purpose

To inform food retail interventions, this study explored food shopping strategies employed by people constrained by limited budgets but residing in an urban environment offering numerous retail options.

Approach

Qualitative study incorporating semi-structured interviews and shop-alongs.

Setting

East Harlem, New York City.

Participants

37 East Harlem residents participated in interviews, of whom 15 participated in shop-alongs.

Methods

Interviews and shop-alongs were conducted in English, Spanish, and Mandarin Chinese. Interview transcripts were analyzed using a grounded theory approach. Data from shop-alongs were used to supplement interview findings.

Results

Participants shopped 1-2 times at an average of 4 retail locations per week. Two key themes emerged: (1) planning trips and choosing venues; and (2) shopping experiences and perceptions of stores. Price was the primary driver of store choice, followed by product quality and variety. Substantial time was invested in shopping. Most English- and Spanish-speaking participants shopped in East Harlem. Chinese American participants shopped in Chinatown due to language concordance, availability of culturally-preferred foods, and proximity to other services.

Conclusion

East Harlem residents invested substantial planning, time and effort in food shopping to acquire sufficient food for their households on limited budgets. These findings offer insight into how residents interact with food environments and key drivers of decision-making about food shopping that affect decisions about where to shop and what to purchase.
A Case of Delayed and Persistent Carbamazepine Overdose Treated With Hemodialysis, Plasmapheresis, and Neostigmine
Authors: Cameron-Coffill Kayla M , Ondiveeran Hari K , Walsh Liam D
Published: August 2024

Carbamazepine is utilized for various indications. Due to its pharmacokinetic profile and drug properties, toxicity can be delayed and persistent despite supportive care. We report a severe case of intentional carbamazepine toxicity in a carbamazepine naive individual mimicking brain death that was not diagnosed until three days after consumption of carbamazepine when the patient was comatose. Symptoms of overdose persisted for several days despite attempted treatment with activated charcoal and whole bowel irrigation, hemodialysis, and plasmapheresis. Symptoms only began to improve with bowel evacuation as a result of administration of neostigmine intravenously plus hemodialysis and plasmapheresis additionally. Despite previous literature that reported success with hemodialysis and/or plasmapheresis we did not find either to be overly effective in our case possibly due to lack of ability to perform multidose activated charcoal and whole bowel irrigation. To our knowledge this is one of the few cases of carbamazepine overdose utilizing both hemodialysis and plasmapheresis but without activated charcoal and the only case report in which neostigmine was administered as an attempt to remove drug via the gastrointestinal tract with success.
Artificial intelligence and public administration: Understanding actors, governance, and policy from micro, meso, and macro perspectives
Authors: Criado J Ignacio , Sandoval-Almazán Rodrigo , Gil-Garcia J Ramon
Published: August 2024

Artificial Intelligence (AI) has become one of the most prominent topics in public policy and administration studies over the last years. Despite the attention to AI in this field isn’t entirely new, the universality of these group of technologies has radically increased the attention of scholars around the globe. This expansion of AI in the public sector entails the exploration of renovated foundations of analysis, not only to understand the novelty of these technologies, but also to connect these processes of adoption and implementation with other debates in public policy and administration. To do so, in this article we debate the need of an analytical framework of AI in the public sector based on the three levels of public administration: macro, meso, and micro. Also, we review the state-of-the-art in the field using the articles presented in the special issue on Artificial Intelligence and Public Administration: Actors, Governance, and Policy. Form here, we propose studying AI using a combination of macro, meso, and micro levels of public administration. We assume this will help to broadly apprehend how and why people, policies, and institutions interrelate with AI in public sector settings, and which effects can be expected from these processes in public administration.
The role of sustainability and SDGs in patent valuation
Authors: Rantasaari Krista
Published: August 2024

There is an urgent demand for developing and adopting environmentally sound technologies (ESTs). This article studies the existing methodologies for incorporating sustainability considerations into the complex field of patent valuation, focusing on start-ups and growth companies. Due to the agility and innovative potential, growth companies play a pivotal role in advancing ESTs, and patents serve as crucial instruments in facilitating technology transfer, provided that effective patent valuation processes are in place. The article shows the diversity of guidelines and standards available for patent valuation, highlighting that they provide valuable non-binding frameworks. However, the study reveals that most existing patent valuation standards do not explicitly address sustainability concerns, except for the World Intellectual Capital Initiative (WICI), which is actively engaged in the sustainability discourse. Overall, the challenge is how companies observe sustainability in the valuation process. The United Nations Sustainable Development Goals (SDGs) emerge as a global framework that can guide patent valuation practices. The article highlights the need for patent valuation guidelines to embrace sustainability as an integral component, ensuring that sustainability and ESTs are integrated throughout every phase of the patent life cycle. Acknowledging that start-ups and growing companies often face financial constraints and need guidance in their valuation practices is crucial.
The impact of protean career on career sustainability: Mediating effect of perceived employability
Authors: Nimmi P M , Cabral Clement , Thrasyvoulou Georgia , Mariani Marco Giovanni , Petruzziello Gerardo
Published: August 2024

Despite the studies on protean career attitude in the career management literature, career sustainability and its potential outcomes have been subjected to study with limited empirical evidence. With this context, this study propounds a conceptual model connecting protean career orientation and perceived employability with career sustainability. Besides, sequentially, we posit that lifelong learning and proactive skill development mediate the relationship between protean career orientation and perceived employability. To establish the relationship, this study gathered data from Italy and Cyprus. Structural equation modelling was performed using the data collected. The results indicated serial mediation paths through which protean orientation impacts career sustainability.
Palliative Care Utilization Among Hospitalized Patients With Hepatocellular Cancer: A Nationwide Study in the Pandemic Era (2019-2021)
Authors: Aldecoa Kim Abbegail Tan , Macaraeg Chef Stan L. , Abougergi Marwan S. , Krishnamoorthy Geetha , Arsene Camelia
Published: August 2024

Background: Palliative care addresses a range of needs, from symptom management to providing support to patients with hepatocellular cancer (HCC) and their families throughout the illness. However, research on palliative care in HCC remains limited, particularly during the COVID-19 pandemic. This study investigates the healthcare utilization associated with palliative care referral among patients with HCC. Methods: This is a retrospective cross-sectional analysis conducted using the National Inpatient Sample (NIS) database from 2019 to 2021 among patients with HCC age ≥18 years. Results: Among the 35,220 hospitalizations with HCC as the principal diagnosis, 18.7% received inpatient palliative care referrals. Factors associated with increased palliative care referrals included age ≥65 years, Midwest region, Charlson Comorbidity Index (CCI) score ≥3, and end-of-life care, as reflected by discharge resulting in death. No racial or insurance disparities were observed. Palliative care consultations were associated with lower total hospital costs ($20,573 vs $26,035, <0.0001). A higher prevalence of “do-not-resuscitate” status was also found among patients with palliative care referrals. Conclusion: The study provides an understanding of palliative care utilization across pre-pandemic and pandemic periods. Factors such as advanced age, hospital region, and underlying comorbidities influenced the likelihood of referral, with no discernible racial or insurance disparities identified. Palliative care involvement has also been shown to provide cost-effective supportive care with lower hospital costs. These findings provide invaluable guidance for optimizing the integration of palliative care alongside HCC management.
Using the SCAR-Q to Evaluate Morbidity of Scars in Craniosynostosis Repair
Authors: Parikh Neil , Hu Kevin G. , Allam Omar , Lewis Katelyn , Ihnat Jacqueline M. , Rancu Albert L. , Boroumand Sam , Persing John A. , Alperovich Michael
Published: August 2024

Objective

While previous literature has investigated the psychosocial impact and aesthetic satisfaction associated with post-operative scarring for certain pediatric craniofacial conditions, the impact of the scar burden resulting from craniosynostosis surgery has not been adequately studied.

Participants

SCAR-Q was shared with patients ages 8 and older. Thirty-two complete patient responses were recorded.

Interventions

SCAR-Q is a PROM that consists of three independent scales - appearance, symptoms, and psychosocial impact - associated with a scar.

Main Outcome Measures

Mann-Whitney U, linear regression, and Pearson correlation tests were used to evaluate associations between the scales, in addition to patient characteristics such as sex and suture involvement.

Results

Mean ages at time of surgery and survey completion were 9.65 ± 10.10 months and 12.10 ± 3.92 years, respectively. Mean scale scores were 81.5 ± 17.9 for appearance, 86.8 ± 12.4 for symptoms, and 79.3 ± 25.7 for psychosocial impact. Higher patient dissatisfaction with scar appearance correlated with more scar-related symptoms (r = 0.389; p = 0.028) and a greater psychosocial impact (r = 0.725; p < 0.001). SCAR-Q scales did not significantly correlate with age at surgery, age at survey completion, type of synostosis, or type of surgery; however, female patients reported lower mean appearance (65.4 vs. 86.0; p = 0.012) and psychosocial impact (57.3 vs. 85.5; p = 0.010) scores when compared to their male counterparts.

Conclusions

It is vital that surgeons discuss patients’ aesthetic satisfaction following craniosynostosis surgery in order to appropriately address and limit deleterious, long-term physical and psychosocial outcomes.
School–University Partnership in Vietnam From School Teachers’ Perspectives
Authors: Cao Hong , Tran Anh
Published: August 2024

This article investigates partnership practices between initial teacher education (ITE) institutions in Vietnam using questionnaires and focused-group interviews. The results revealed that: (a) current partnerships mostly aimed at improving the professional capacity of school teachers and quality of student learning; (b) limited activities exist in collaborative research, curriculum development, and ITE; and (c) of different aspects of a partnership, more attention need to be paid to reviewing partnership directions, involving different stakeholders in the decision-making process, and creating opportunities for staff to work in each other's organization. The results of this study carry significant implications for the development, management, and support of partnership activities. Moreover, these findings have the potential to contribute to a broader international comprehension of partnership activities, particularly in contexts where knowledge in this area is limited.
Measuring Continuous Affect in Daily Life With Intensity Profile Drawings
Authors: Cloos Leonie , Mestdagh Merijn , Vanpaemel Wolf , Ceulemans Eva , Kuppens Peter
Published: August 2024

We examined continuous affect drawings as innovative measure of affective experiences over time. Intensive longitudinal data often rely on discrete assessments, containing “blind spots” between measurements. With continuous affect drawings participants visually depict their affect fluctuations between assessments. In an experience sampling study, participants ( N = 115) rated their momentary positive and negative affect 6 times daily. From the second daily rating on, they additionally drew their positive and negative affect changes and reported affective events between assessments. They received one measurement burst between assessments daily. The strength of the approach is a substantial amount of informational gain (average 7%) over linearly interpolated points between assessments. The additional information was subsequently categorized into positive and negative affect peaks and valleys, each occurring once a day per person on average. The probability of detecting peaks and valleys increased with reported events. The drawings correlated positively with momentary affect scores from the burst. Yet, the drawing predicted the bursts less well suggesting that the momentary ratings may yield different information than the drawings. Although the timing of retrospective drawings is less precise than individual momentary assessments, this method provides a comprehensive understanding of affective experiences between assessments, offering a unique perspective on affect dynamics.
A Research Protocol for a Phase II Single-Arm Clinical Trial Assessing the Feasibility and Efficacy of Neoadjuvant Anastrozole in Patients With Luminal Breast Cancer and Low Proliferative Index: The ANNE Trial
Authors: Paiva Carlos Eduardo , Silva Alinne Tatiane Faria , Oliveira Izabella da Silva , Guimarães Vitor Souza , Lacerda Domício Carvalho , Teixeira Gustavo Ramos , Watanabe Anapaula Hidemi Uema , Onari Nilton , Paiva Bianca Sakamoto Ribeiro , Oliveira-Junior Idam de , Marques Marcia Maria Chiquitelli , Maia Yara Cristina de Paiva
Published: August 2024

Introduction

Neoadjuvant endocrine therapy (NET) is recommended for the treatment of invasive breast cancer (BC), particularly luminal subtypes, in locally advanced stages. Previous randomized studies have demonstrated the benefits of aromatase inhibitors in this context. However, NET is typically reserved for elderly or frail patients who may not tolerate neoadjuvant chemotherapy. Identifying non-responsive patients early and extending treatment for responsive ones would be ideal, yet optimal strategies are awaited.

Aims

This non-randomized phase 2 clinical trial aims to assess NET feasibility and efficacy in postmenopausal stage II and III luminal BC patients, identifying predictive therapeutic response biomarkers. Efficacy will be gauged by patients with Ki67 ≤ 10% after 4 weeks and Preoperative Endocrine Prognostic Index (PEPI) scores 0 post-surgery. Study feasibility will be determined by participation acceptance rate (recruitment rate ≥50%) and inclusion rate (>2 patients/month).

Methods

Postmenopausal women with luminal, HER2-tumors in stages II and III undergo neoadjuvant anastrozole treatment, evaluating continuing NET or receiving chemotherapy through early Ki67 analysis after 2 to 4 weeks. The study assesses NET extension for up to 10 months, using serial follow-ups with standardized breast ultrasound and clinical criteria-based NET suspension. Clinical and pathological responses will be measured overall and in the luminal tumor A subgroup. Toxicity, health-related quality of life, and circulating biomarkers predicting early NET response will also be evaluated.
Prognosis and Factors 4 to 10 Years After Deep Vein Thrombosis: A Long-Term Follow-up Cohort Study
Authors: Yao Jinhan , Han Mengru , Shi Jin , Wang Weina , Zhang Jiayi , Zhang Yuquan
Published: August 2024

Post-thrombotic syndrome (PTS) is one of the most common long-term complications of lower extremity deep vein thrombosis (DVT). In order to study the long-term adverse prognosis of patients with DVT, explore the influencing factors for the prognosis of DVT, and provide a reliable reference for future research in the field of venous thrombosis, we collected and summarized information about the incidence of PTS, the PTS score and grading, the associated symptoms and drug-related adverse reactions in 501 patients with DVT. In our study, 54.1% of patients with DVT (271 of 501) experienced indications and manifestations of PTS, the male to female ratio was approximately 1:1. During the long-term follow up, the most common symptoms of PTS were anterior tibial edema and pain. By statistical analysis, we found that the outcome of thrombosis was the influencing factor of PTS score (1-4 points, P<.05). The grading of PTS was primarily influenced by the history of varicose veins and DVT in the lower extremities. The duration of taking antithrombotic drugs affected the outcome of thrombosis ( P<.05), especially among the female patients. In addition, varied factors, such as lower extremity DVT complicated with pulmonary embolism and the duration of antithrombotic drug use were found to increase the chances of experiencing drug-related adverse reactions (odds ratio [OR]=2.798, 95% confidence interval [CI]: 1.413-5.541 / OR=2.778, 95% CI: 1.231-6.269). The above 2 factors were significant only among female patients with DVT (OR=4.03, 95% CI: 1.608-10.103 / OR=3.918, 95% CI: 1.123-13.669).
Does No Mean No? Situational and Dispositional Factors Influence Emerging Adult Men’s Intentions to Use Assault Tactics in Response to Women’s Sexual Refusal During Hookups
Authors: McKinnon Allison M. , Mattson Richard E. , Lofgreen Ashton M.
Published: August 2024

Hookups can result in sexual assault when men do not listen to requests from women to stop. It is thus important to identify factors that influence men’s decisions to override direct refusals in these situations. Presently, we administered first-person vignettes depicting a prototypical hookup wherein the woman refuses the man’s attempt to escalate intimacy. Using a national sample of emerging adult men ( N = 420), we found that they on average did not completely rule out coercive or forcible tactics, but those elevated on rape myth acceptance, hypermasculinity, and psychopathy were uniquely at risk of assault when controlling for several other traits known to correlate with rape. Participants also reported being likelier to use coercive sexual practices when refusals occurred at higher levels of sexual intimacy already attained. Notably, diagnostic analyses revealed that a subset of men had a disproportionate influence on the regression estimates, and that these men were not only elevated across a range of assault-relevant traits, but also endorsed higher likelihoods of using coercion and force in the face of female sexual refusal. Although removal of these cases did not substantively alter the results, exploratory analyses revealed that these individuals responded differently to situational factors in ways that suggested sexual opportunism. Theoretical and practical implications of these findings are discussed.
Diagnostic ability of the corneal anterior and posterior surface area calculated by corneal modelling approach in early stage keratoconus patients
Authors: Özelbaykal Bahadır , Kaya Ozan , Kasım Burcu , Birkandan Tolga , Koçluk Yusuf
Published: August 2024

Purpose

To investigate the discrimination ability of the corneal anterior and posterior surface area between patients with keratoconus stage 1 and normal individuals.

Methods

In this retrospective study, 116 eyes of 116 normal individuals and 366 eyes of 366 keratoconus patients were included. Keratoconus patients were divided into six groups according to the topographic keratoconus classification of Pentacam. Anterior and posterior surface data of sagittal (SM) and elevation maps (EM) were exported from Pentacam, and human corneal models were created employing the software utilizing the PyVista module of Python programming language. The anterior and posterior corneal surface area (a-CSA and p-CSA) of SM and EM were calculated by the software ranging from central 3 to 8mm diameter.

Results

Anterior and posterior CSA values were higher in KC patients compared to normal individuals (p < 0.001). The p-CSA for SM and EM measured at the central 3mm was higher in patients with KC-1 compared to normal eyes ( p = 0.002, p = 0.005, respectively), For both maps, a-CSA and p-CSA measured at the central 4 and 5mm were higher in KC-1 compared to normal individuals ( p < 0.05). The highest area under the curve (AUC) values in the diagnosis patients with KC-1 were obtained from 3mm p-CSA for SM (AUC: 0.8338), 3mm p-CSA for EM (AUC: 0.7999), 4mm p-CSA for SM (AUC: 0.8531), 4mm p-CSA for EM (AUC:0.7948), 5mm p-CSA for SM (AUC: 0.8455), 5mm p-CSA for EM (AUC:0.7614).

Conclusion

The corneal surface area as a parameter, especially for central 3, 4, and 5mm, has a discrimination ability in diagnosing keratoconus disease and distinguishes normal eyes from KC-1 eyes.
A bibliometric and citation network analysis of crosslinking
Authors: Sánchez-Tena Miguel Ángel , Pérez Clara Martínez , Villa-Collar Cesar , Alvarez-Peregrina Cristina
Published: August 2024

Purpose: Research on crosslinking has focused mainly on trying to slow the progression of keratoconus. The objective of this bibliometric analysis is to determine the relationships between the different publications and authors. As well as to identify the different areas of research on crosslinking. Methods: Web of Science (WOS) was the database for the search of publications for the period 1972 to December 2023, using the terms: crosslinking, cross-linking, ocular, vision, visual, cornea, ectasia AND Keratoconus. The analysis of the publication was performed using the CitNetExplorer, VOSviewer and CiteSpace software. Results: 7161 publications and 59415 citation networks were found. The year with the most publications is 2021, a total of 571 (7.97%) publications and 135 citation networks. The most cited publication was “Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus” published by Wollensak et al. in 2003, with a citation index of 1780. Using the Clustering function, five groups were found that cover the main research areas in this field: keratoconus, corneal transplantation, cataracts, corneal inflammation and axial growth. Conclusion: The treatment of keratoconus continues to be the topic of interest in this area of research. However, in recent years there has been an increase in research on how crosslinking helps to slow down axial growth.
Removable regulating sutures during trabeculectomy for a safer and more effective intraocular pressure control
Authors: Savastano Alfonso , Maiola Emanuele , Carlà Matteo Mario , Gambini Gloria , Boselli Francesco , Giannuzzi Federico , Rizzo Clara , Rizzo Stanislao
Published: August 2024

Purpose

Comparing the effect of standard trabeculectomy with direct sutures versus trabeculectomy with compression and everting sutures.

Methods

Mono-centric randomized prospective comparative study on 38 glaucomatous eyes undergoing trabeculectomy: 19 with standard fixed sutures (group A) and 19 withremovable regulating sutures (group B). Preoperatively and at day-7, 1-month, 2-months, 3-months and 6-months after surgery, we recorded best-corrected visual acuity (BCVA), intraocular pressure (IOP) and possible complications. Complete, partial success and failure rates were recorded at the end of the study.

Results

In group B, we pulled everting sutures with the “horse bridle” technique at the 14th day, and successively removed all sutures between the 14th-30th post-operative day. At month-1, we recorded a significant IOP reduction in both groups (mean reduction of 11.5 mmHg for group A and of 14.4 mmHg for Group B, p = 0.001 and p < 0.0001, respectively). Furthermore, group B showed a significantly lower IOP than group A (−4.2 mmHg, 95% confidence interval [CI] −7.0 to −0.5 mmHg for group B, p = 0.01). At 2, 3 and 6-months, no significant IOP differences were reported between the two groups (all p > 0.05), but failure rate was higher for group A (21%) than for group B (11%). No differences in visual outcomes at any timepoints were noted.

Conclusions

Trabeculectomy with removable regulating sutures showed a good safety profile, comparable to standard trabeculectomy. Moreover, we reported a lower IOP one month postoperatively, suggesting this technique may optimize early management of trabeculectomy.
Troubleshooting the connected home: Exploring the perspectives of non-initiators
Authors: Teigen Helene Fiane
Published: August 2024

Living with technology often entails work related to management and repair of it. The emerging literature on the work that goes into managing home networks and digital technologies has described it as ‘digital housekeeping’. Within this literature, a single person is often identified as being responsible for the domestic tech work and this is the same person who initiated bringing the technology into the home. However, remaining household members and persons who have been gifted with such technologies are under-researched, despite studies showing them to be vulnerable to skewed power dynamics and technical malfunctions when the responsible person is not around. Applying digital housekeeping as a theoretical lens, this article explores how people identified as ‘non-initiators’, that is, those living with smart home technologies but who did not initiate bringing the technology into their home, deal with malfunctioning devices. Drawing upon interviews with five identified non, this study provides an in-depth exploration of their troubleshooting routines conceptualized as diagnosing, performing, and delegating. Findings suggest that non-initiators also engage in digital housekeeping through troubleshooting, although this work is largely unacknowledged by themselves and others. Moreover, the image of non-initiators as vulnerable is nuanced by highlighting their active participation in the connected home. Non-initiators use smart home devices for daily activities, and they have the knowledge, skills, and resources to draw upon when encountering malfunctions. Furthermore, the non-initiators’ troubleshooting routines are affected by the devices’ materiality, the household’s social dynamics, and to some degree by societal perceptions of technology, age, and gender. This paper contributes to the existing literature on smart homes and digital housekeeping by emphasizing non-initiators’ contribution to digital housekeeping and by highlighting how their agency is asserted in line with their interests and needs.
Research on engine dynamic torque modeling for torsional vibration analysis of vehicle powertrain
Authors: Chen Long , Tao Lei
Published: August 2024

In order to improve the accuracy of dynamic torque model of engine, a simulation model of quasi-transient engine dynamic torque under all operating conditions was established considering the influence of throttle opening. Firstly, the calculation model of engine output torque and cylinder pressure is established according to the kinematic relation of crank linkage mechanism. Secondly, BP neural network is used to establish the mapping relationship model of throttle opening, rotational speed, and cylinder pressure ratio data. In order to solve the contradiction between calculation accuracy and efficiency of engine cylinder pressure interpolation, a quadratic interpolation method is proposed, which refines data to improve interpolation accuracy, and improves calculation efficiency by online adjacent interpolation, and completes the construction of dynamic torque simulation model of engine in all working conditions. Finally, the experimental data of dynamic torque characteristics of the engine at different speeds are used to verify the accuracy of the model calculation. By using the verified engine model, the dynamic operating characteristics of variable valve opening and variable speed are simulated and analyzed. The results show that the model established in this paper can effectively reflect the dynamic characteristics of the engine, and the model is suitable for the simulation of the torsional vibration of the vehicle powertrain under steady and unsteady conditions.
Global misinformation trends: Commonalities and differences in topics, sources of falsehoods, and deception strategies across eight countries
Authors: Cazzamatta Regina
Published: August 2024

In a quantitative content analysis of 3,154 debunking articles from 23 fact-checking organizations, this study examines global misinformation trends and regional nuances across eight countries in Europe and Latin America (UK, DE, PT, SP, AR, BR, CL, and VZ). It strives to elucidate commonalities and differences based on political and media system indicators. Notably, countries with a substantial online presence of far-right parties avoid disclosing (fake) ordinary accounts to evade engaging in inauthentic coordinated actions. While entirely fabricated stories are infrequent, they stand out in Brazil and Spain, the two countries with higher political polarization. Despite variations, aggregated forms of fabrication (invented, manipulated, imposter, or decontextualized content) are more prominent in Latin America due to high social media use for news and low reliance on public media. Conversely, in Europe, countries are more impacted by misleading (cherry-picked, exaggerated, and twisted) information.
Teacher expertise in early childhood instruction: Cross-analysis of language policy and culturally sustaining pedagogies with multilingual learners
Authors: Dunham Heather , Holyoke Erica , Crook Katie
Published: August 2024

This qualitative study explores intersections between U.S. language policies (federal and state-level) and instructional practice in early childhood settings for multilingual learners (MLs). We draw on the theoretical framework of culturally sustaining pedagogy to engage in a critical content analysis of U.S. federal and state-level policy from three states. In the cross-analysis of policy and pedagogy, we also examine data from ML teachers’ instructional artifacts, open-ended surveys, and semi-structured interviews. The findings provide insight into how educators draw on culturally sustaining and asset-based approaches to teaching MLs. Additionally, findings demonstrate how ML teachers negotiate policies that prioritize English language and academic achievement and those focused on teaching discrete language skills (i.e., phonological awareness and phonics) by continually centering children’s linguistic and cultural repertoires. Participants in this study advocated for linguistic pluralism in their instruction and as leaders in their schools and communities. The study further illustrates how policies mandate specific aspects of instruction and leave linguistically inclusive pedagogies to individual educators. This tension can be beneficial for educators’ freedom in interpreting and navigating the policy in their classroom but can also create disparities for young learners and their literacy opportunities. The significance implies a need for revisiting early childhood ML teachers’ role in creating policy that fosters linguistic and cultural inclusion in language and literacy teaching.
Interactions with new-to-teacher language resources: Supporting translingual composing in a multilingual elementary classroom
Authors: Rowe Lindsey W.
Published: August 2024

Educators should support multilingual students’ translingual writing. However, it can be challenging for teachers to support students’ composing in languages that teachers do not speak. Drawing on a community translanguaging lens, this paper explores this issue by asking: How did teachers talk about and interact with language resources that were new to them while supporting translingual writing in an English-medium classroom? Data were collected using ethnographic and practitioner research methods across 1 year in one second-grade writing workshop in the U.S. Students spoke Spanish, Korean, French, Tagalog, or English, and classroom teachers spoke English and Spanish. Data analysis first involved descriptive coding of videorecorded composing interactions to identify every teacher interaction involving a new-to-them named language. These events were then re-examined using constant comparative coding to identify interactional patterns. This yielded three main findings; teachers: (1) positioned students as language experts and themselves as language learners, (2) drew on shared language resources to support student writing in new-to-teacher languages, and (3) expanded audiences to support student writing in new-to-teacher languages. Implications include pedagogical steps teachers can take to support students’ use of new-to-teacher languages while writing, and ideological and social implications of teacher talk about those languages.