bluuebunny/crossref_metadata_2025 huggingface dataset:
Myeloid differentiation primary response 88 expression in central nervous system lymphomas
Authors: Balık Berrin , Mutlu Yaşa Gül , Sevindik Ömür Gökmen
Published: November 2024

Aims: A prominent adaptor protein that signals from many receptors called myeloid differentiation primary response 88 (MYD88) coded by MYD88 gene was evaluated. Our aim was to record the level of MYD88 expression and its relation with clinicopathological parameters in both primary and secondary Central Nervous System (CNS) Lymphomas.
Methods: MYD88 protein expression was analyzed by two different classification using immunohistochemistry (IHC) in ten patients who were diagnosed in our hospital. The samples that were collected from patients before treatment were evaluated and specified by a hematopathologist. Demographic and clinical information of the patients were obtained from hospital database and files. The primary outcome was the presence and prevalence of MYD88 expression. Secondary outcomes were determined as the evaluation of the relationship between MYD88 expression and disease prognosis.
Results: MYD88 protein expression was examined in 10 in-patients of which 9/10 cases (90%) expressed the protein in wide ranges of intensity and density. Six patients (60%) expressed high-level of MYD88 protein where as one patient did not, and three patients (patient 2,3,9) expressed low quantity of MYD88 protein that deceased after diagnosis. Most CNS lymphoma patients had an ABC-like immunophenotype.
Conclusion: Primary and secondary CNS lymphomas showed expression of MYD 88 protein without regards of lymphoma subtype.
Diagnostic white blood cells can be a predictor for mutation existence in myelodisplastic syndromes: the role of next generation sequencing
Authors: Yılmaz Seda , Günay Ayşe , Cırık Salih , Baştürk Abdulkadir , Başdemirci Müşerref , Balasar Özgür
Published: November 2024

Aims: Myelodisplastic syndromes (MDS) are hematological disorders originating from clonal damage and characterized by inefficient bone marrow activity. The existence of mutations has been shown to play a significant role in risk, treatment response, turnover to acute myeloid leukemia, prognosis, and overall survival. Next-generation sequencing (NGS) is a technique that detects gene mutations and has been the subject of studies for detecting MDS-related mutations.
Methods: We conducted a study on 33 MDS patients during the period of 2021–2023. Patients were analyzed for the existence of mutations with the NGS technique, and the hematological parameters, transfusion need, IPSS, and IPSS-R scores of these patients were recorded.
Results: 15 out of 33 patients (45.5%) were tested for mutations. WBC levels at the diagnosis of patients with type 1 number somatic mutations were higher than in other groups, 7056.25, 2416.67/µL, and 3036.67/µL, respectively (p = 0.048). The ratio of neutrophil and lymphocyte values recorded and NGS positive were higher than those tested negative (1.56 and 3.51, respectively). Patients with the type 1 mutation had higher WBC levels than patients with the type 2 and type 3 mutations, 7056.25/µL, 2416.67/µL, and 3036.67/µL, respectively. 
Conclusion: Genetic mutations are common in MDS patients, and NGS is a useful tool to detect them. Understanding the role of mutations in the matter of risk classification, treatment response, and prognosis is quite important, and larger-scale studies are needed.
Can bispecific antibody therapies for multiple myeloma be a risk factor for the development of secondary haemotopoietic malignancy? A case report
Authors: Tan Taner , Doğan İbrahim Öner , Bozdağ Sinem Civriz
Published: November 2024

With the introduction of many new treatments in multiple myeloma and the effective use of autologous stem cell transplantation, significant prolongation of overall survival has been achieved. Despite this ,there is still no cure for this disease. Relapses/refractory conditions seen after multiple treatments have brought the use of new agents to the agenda. Elranatamab is a humanized bispecific antibody used in relapsed or refractory multiple myeloma which targets B-cell maturation antigen on myeloma cells and CD3 on T cells . With this mechanism, elranatamab could activate T cells to induce cytotoxic T-cell response against myeloma cells. (1) Although we have an idea and experience about the short-term adverse effect profile and management, our ideas about the long-term adverse effect and safety profile are not yet clear due to the fact that it is a very new agent. We described an unexpected hematologic event during the use of elranatamab in the following case.
Kikuchi-Fujimoto disease: a rare cause of fever and lymphadenopathy in a 19-year-old male
Authors: Çiftciler Rafiye , Çiftciler Ali Erdinç , Selim Cem , Çelik Murat
Published: November 2024

Kikuchi-Fujimoto disease is also known as histiocytic necrotizing lymphadenitis or Kikuchi disease. The disease is a rare, self-limiting condition of an undetermined cause that manifests as protracted lymphadenopathy with or without systemic symptoms. Painful cervical lymphadenopathy accompanied by fevers, leukopenia, and an increased erythrocyte sedimentation rate are its defining features. We reported a 19-year-old male was admitted to the hematology outpatient clinic with cervical lymphadenopathy and B symptoms. He was diagnosed with Kikuchi disease from a lymph node biopsy. He was successfully treated with intravenous immunoglobulin and steroids. The patient's complaints regressed and disappeared. Histopathological features, including lymph node necrosis and histiocytic growth, are used to diagnose Kikuchi-Fujimoto disease. It is regarded as a benign condition. To avoid incorrect diagnoses and needless treatments, medical professionals must be aware of Kikuchi disease while making a differential diagnosis for cervical lymphadenopathy.
A rare case of olfactory neuroblastoma
Authors: Karatlı Salih , Kavak Engin Eren
Published: November 2024

Olfactory neuroblastoma, also referred to as esthesioneuroblastoma, is a rare malignancy of the nasal cavity with an incidence of approximately 0.4 per million individuals. The most frequently encountered symptom is nasal obstruction, though patients may also present with epistaxis and nasal discharge. Management strategies primarily involve surgical resection and radiotherapy, while the role of chemotherapy remains limited. Currently, there is no universally accepted treatment protocol for this condition. This report describes a case of olfactory neuroblastoma staged as Kadish stage C, in which the patient underwent chemoradiotherapy. Follow-up imaging revealed no evidence of disease recurrence. This case suggests that chemotherapy may have a role in the treatment regimen for advanced-stage olfactory neuroblastoma, potentially enhancing therapeutic outcomes in such cases.
A comment on ‘The relationship between hepatocellular carcinoma and resolvin D1’ by Erdin et al.
Authors: Güven İbrahim Ethem
Published: November 2024

We read the article entitled “The Relationship between Hepatocellular Carcinoma and Resolvin D1” by Erdin et al. with great interest. First of all, we congratulate the authors and editorial board for this informative and interesting article. Overall, this study by Erdin et al. demonstrated that Resolvin D1 may be a useful biomarker for predicting the HCC as an alternative to AFP. Further studies are warranted on this topic.
Unravelling the nexus of HIV/AIDS prevalence and economic development challenges in Homa Bay's fisherfolk communities
Authors: Odumbe Sixtus , Nyadoro Kefa , Nyaboga Ibrahim
Published: November 2024

This study investigates the impact of HIV/AIDS-related health issues on the productivity and efficiency of fishermen in Homa Bay County, Kenya. Using a descriptive research design, data was collected from 168 respondents through guided questionnaires and interviews. The findings show that 76.8 per cent of respondents agree that HIV/AIDS has a negative effect on productivity, with many fishermen missing up to three fishing days per week due to illness. This absenteeism results in significant economic losses, with larger fishing boats losing an estimated KES 250,661 weekly and smaller boats losing around KES 104,357. Reduced fishing activity also translates to a decline in the weekly fish catch, with large boats averaging 1,754.6 kg compared to their full capacity and small boats producing only 730.5 kg. These reductions in productivity and income highlight the severe vulnerability of fishing communities to the health challenges posed by HIV/AIDS, underscoring an urgent need for comprehensive interventions. Recommendations include strengthening healthcare infrastructure, implementing targeted awareness and prevention programs, and providing economic support mechanisms to mitigate the financial impact of HIV/AIDS-related illnesses on fishermen and their families. By addressing these issues comprehensively, policymakers and stakeholders can help build resilient and sustainable fishing communities equipped to withstand the challenges posed by HIV/AIDS.
The Symbolism of Fire in Al-Jahiz Literature
Authors: Abdel Rahim Mu'nis Abbas
Published: November 2024

We pass through our Arab literature paradoxes that need pauses and deductions when we find that the Arab poet has given them special attention, so we realize the great literary value of them, and one of the most important poetic paradoxes is the symbolism of fire in it،or need, and so on, in addition to its important employment without its names, but in our research we adopted its explicit name for clarification and constancy, By examining this idea among the Abbasids, we learned that they were not an innovation of poets, but rather they were an extension of an ancient generation of poetry and its improvisation. Ideas became more clear, developed, and expanded, thus occupying more space for the growth of cultures, the multiplication of religions, and the birth of various forms of sects and bees. The symbolism of fire expressed the culture of every sect, and therefore it is aneed. It is an inherent value for people of different walks, so we defined it and employed it, then explained its symbolism in a second axis and concluded by defining the most prominent results of the study, and all of this is a favor from my Lord, and Heis a good helper.
The Image of Darkness in Selected Poems by (George Gordon) Lord Byron
Authors: Haraj Hassan Abdul Ameer , Haraj Sahar Abdul Ameer
Published: November 2024

Byron in some of his poems utilizes darkness as an image. This image is significant because it bears a hidden political, social and personal meaning. The use of the image of darkness is to express some of Byron's ideas like the sense of the end of the world, the social collapse in relation to its order or hierarchy and the consequences of all these on mankind and the species on earth. It might be a way to show the poet's future view of the universe. In some of those poems he tries to show his view about certain theme in life like nature, spiritual love, and beauty or even political ideas. Byron, in those poems and through utilizing darkness, was after presenting a political, personal as well as ecological views of the world. Consequently, darkness becomes a way to envision and shape the universe in a special image.
The Effectiveness of International Efforts to Protect and Encourage Foreign Investment
Authors: Salman Sabah Awad
Published: November 2024

The development of countries is measured by the amount of investments made on their land, and actual productive investment is only achieved through a safe and productive environment. This safe environment does not only include security, tranquility and the absence of physical attacks on the investor, but also includes the extent of his confidence in the national judiciary and its procedures. However, investors often resort to arbitration away from the judiciary of the invested country due to their lack of confidence in it or the lack of objectivity of the judiciary towards the investor and its bias towards his home country. The foreign investor may be exposed to unilateral procedures carried out by the host country for investment based on its sovereignty, and these procedures cause serious harm to the investor, which requires searching for mechanisms to protect the investor in the rules of international law. There is objective protection represented by bilateral and collective agreements, and there is procedural protection represented by diplomatic protection and arbitration. From this standpoint, countries have developed several means through which the foreign investor can be protected, and all countries must enact a law that suits these means and works to implement them properly.
Contribuições do Design para a elaboração de materiais didáticos adequados a crianças com TDAH
Authors: Pozza da Costa Fernanda , Triska Ricardo , Schmidt Alves Díaz Merino Giselle
Published: November 2024

Este estudo insere-se no contexto do ensino-aprendizagem de crianças com TDAH. Teve como objetivo propor diretrizes para elaboração de materiais didáticos voltados a estudantes com TDAH, de séries iniciais do ensino fundamental. O estudo, de natureza analítica, foi conduzido a partir de dados qualitativos obtidos em entrevista semiestruturada realizada com uma psicopedagoga, especialista em ensino-aprendizagem de crianças com transtornos de neurodesenvolvimento e distúrbios de aprendizagem. A coleta de dados também envolveu a análise de questões de provas aplicadas a uma criança de 7 anos, com TDAH, estudante do 2º ano do ensino fundamental. A amostra reuniu 9 questões retiradas de provas escolares. A partir das informações obtidas realizou-se a análise de conteúdo, fazendo o cruzamento com o referencial teórico adotado, que reuniu as áreas da Educação e do Design. Como resultados destaca-se: a identificação das características dos materiais didáticos analisados que não contribuem para a compreensão do conteúdo por crianças com TDAH; proposição de dez diretrizes para a estruturação visual de materiais didáticos que auxiliem no direcionamento do foco atencional dos estudantes. Com o estudo também se identificou oportunidades de desdobramentos para outras pesquisas na área.
Facilitating reading for people with dyslexia: a narrative review of recommendations for text formatting
Authors: Crivellari Camargo Murilo , Angelo Barela José , Faria Teixeira Letícia , Paschoarelli Luis Carlos
Published: November 2024

Dyslexia, a disorder characterized by difficulties in learning to read and write, has aroused interest in many different areas of knowledge, including Information Design. Many recent studies have aimed at testing text formatting variables to design recommendations; however, specific guidelines are still scarce in literature. In this sense, this study conducted a narrative literature review on 19 articles addressing text formatting recomendations for people with dyslexia, including typography, layout, colors, media and images and compared to those stablished by the Dyslexia Style Guide (DSG) (2023). The results reveal that some DSGrecommendations are well accepted among the scientific community while others, as well as some gaps regarding the topic, still require further investigation.
Acumulación originaría y desarrollo del capitalismo en El Salvador ; Democracia y desarrollo en América Latina
Authors: A. M.  , S. M.
Published: November 2024

No abstract available.

ECA Estudios Centroamericanos, Vol. 37, No. 402, 1982: 301-302.
Integration of Social Networking Sites in the English Classroom: My Signature Pedagogy
Authors: Suri Sunita
Published: November 2024

This paper is based on an English teacher’s reflection; she shares her experience of using Social Networking Sites (SNS) to improve English writing skills in limitedly resourced secondary-level classrooms in Nepal. The narratives were revisited and reviewed based on the conversation history of SNS groups to see the learning dynamism, and they were subsequently analyzed and interpreted under themes and subthemes. The paper shares the major takeaways of the reflection.
Healthcare Workers' Perceptions and Attitude towards Sexuality and Pregnancy of Disabled Women in Nairobi: Implications for Sustainable Development Goals
Authors: Otieno Brezhnev Henry , Selvam Sahaya , Akoth Stephen Ouma
Published: November 2024

The Sustainable Development Goals (SDGs) focus on inclusivity and have a specific reference to ‘leave no one behind’. But disabled women are discriminated against, particularly in the context of sexual and reproductive health and rights, which has negative effects on Kenya’s and global efforts towards inclusive development. This study aimed to explore perceptions and attitudes of healthcare workers on sexuality and pregnancy of disabled women in Nairobi. The study used a cross-sectional study design, surveying 145 healthcare workers, specifically doctors, nurses, clinical officers, and community health workers. Data collection involved a perception questionnaire, and the Attitude Toward Disabled Persons (ATDP) scale. Statistical analyses included descriptive and inferential statistics were conducted, including chi-square tests and one-way ANOVA. It was established in the study that the majority of health care workers posited that women with disabilities are sexually active, have sexual drives, and possess functional sexual organs, thus breaking the conception of total asexuality as previously thought. The mean ATDP score of 117.77 (SD=19.25) of the respondents was found to be positive; private healthcare providers displayed more positive attitudes towards disabled women than those employed in public institutions. The study findings highlight the need for comprehensive disability sensitivity training that promotes the dignity and autonomy of disabled women. The study recommends policy initiatives that mandate comprehensive disability sensitivity training, particularly in public facilities, to foster inclusive attitudes and behaviours. Multi-level interventions should prioritize equitable healthcare access, supporting disabled women’s reproductive autonomy and well-being.
Assessing the Determinants Influencing Land Use and Land Cover Change on Land under Maize Cultivation in Likuyani Sub-County, Kakamega County, Kenya
Authors: Shilibwa Henry Kangwana , Masibayi Edward , Neyole Edward
Published: November 2024

For numerous years, human activities have involved modifying land to sustain basic needs like food which has brought various changes on the Earth's surface. Likuyani Sub County is endowed with good climatic conditions for farming and human settlements. The main cause is rapid population increase, which leads to the division of land into smaller and less profitable units. The objective of the study was; to assess determinants influencing (LULCC) Land use Land cover Change in the maize-cultivating areas of Likuyani Sub County Kakamega County, Kenya from 1997 to 2017. The research employed a descriptive and correlational research design. A study sample size of 286 respondents was used. The data collection tools used were questionnaires and Registry Index Maps which were analyzed using SPSS and ArcGIS 10.3 software respectively. The findings from this study showed that land subdivision, population, market forces and crop diversification affected land use and land cover changes on land used for maize cultivation in Likuyani Sub County from 1997 to 2017. Regression analysis statistical techniques revealed the detrimental impact of land alterations on land under maize cultivation. The study recommends restriction of crop diversification in maize growing areas and minimum land size of one hectare. The study informs policymakers to address gaps in land management and reserve land as a means of sustaining livelihoods. The study concludes that that land use and cover dynamics arose due to dynamicity of human activity.
Evaluating the Role of Public Relations in Communicating Legislative Processes to the Public in Embu County
Authors: Rutere Daizy Wawira , Simiyu Kennedy Njasi
Published: November 2024

This study evaluates the role of public relations (PR) in communicating legislative processes within Embu County, Kenya, focusing on how PR practices influence public awareness. The primary objectives were to identify the communication channels utilized by the PR office, assess public engagement during legislative processes, and evaluate the effectiveness of these PR strategies. The target population included Embu County residents aged 18 and above, encompassing diverse socio-economic and demographic backgrounds to capture varied perspectives on PR effectiveness. A descriptive research approach was employed, utilizing both random and purposive sampling to select participants for questionnaires and interviews, resulting in a sample size of 400 respondents, including county officials and members of the general public. Grounded in Stakeholder Theory and Agenda-Setting Theory, this research analyses the impact of social media and traditional media on public communication efforts. Data collected from questionnaires were analyzed using descriptive statistics, while qualitative insights were derived from the content analysis of interviews. The study revealed a significant gap in awareness regarding legislative processes among stakeholders, with 58% of respondents indicating a lack of information about how and when these processes occur. Additionally, 55.5% of participants reported being only somewhat or moderately aware of legislative activities, with some confessing to limited participation. Factors contributing to this stakeholder ignorance include inadequate communication from the county government and insufficient public sensitization efforts. The findings emphasize the need for enhanced communication strategies to educate the public effectively. This study recommends improving the website's functionality, leveraging traditional media for broader outreach, establishing robust feedback mechanisms, and implementing public sensitization campaigns. Furthermore, capacity building for PR practitioners and comparative analyses with other countries are suggested to identify best practices in fostering public participation in governance.
CONFLITOS FAMILIAR NÃO RESOLVIDO ENTRE PARENTE DE PRIMEIRO GRAU:COMO ISSO AFETA A SAÚDE MENTAL.
Authors: Aquino Stephanie das Neves , Lopes Júnior Hélio Marco Pereira , Ramos Elissandra de Jesus Oliveira , Mendonça Francisco Cardoso
Published: November 2024

Conflitos familiares entre parentes de primeiro grau (pais, mães, filhos e filhas) são comuns em muitas famílias de diferenças de personalidade, valores, disciplina e expectativas. Estes conflitos são naturais e fazem parte do desenvolvimento ao longo da vida. As causas incluem divergências na percepção de situações, expectativas sobre desempenho acadêmico ou comportamento, e mudanças na dinâmica familiar. Esses fatores geram estresse e acaba afetando o bem-estar emocional. com pais podem sentir estresse e frustração, e filhos, raiva, tristeza e baixa autoestima. Conflitos não resolvidos podem prejudicar as relações familiares, criando barreiras de comunicação e distanciamento emocional. O estudo foca na compreensão dos conflitos familiares não resolvidos entre parentes de primeiro grau (pais, mães, filhos e filhas), analisando sua natureza, causas e impactos na saúde mental. A pesquisa busca promover uma relação saudável. Foi realizada uma revisão bibliográfica com base em artigos científicos publicados entre 2019 e 2024. Essa abordagem permitiu uma análise detalhada sobre a relação entre conflitos familiares não resolvidos e seus impactos na saúde mental. Indicam que relações familiares saudáveis melhoram significativamente o bem-estar emocional e  o ambiente de diálogo aberto reforça a compreensão e o apoio, aumentando a autoestima e a confiança, e promovendo uma família mais unida e um ambiente emocionalmente seguro. Entender esses conflitos familiares não resolvidos é essencial para promover o bem-estar emocional e fortalecer as relações familiares. Criar um ambiente que incentive o diálogo e onde os membros se sintam compreendidos é crucial para
A IMPORTÂNCIA DO ENFERMEIRO NA TRIAGEM DE PACIENTES EM UNIDADES DE EMERGÊNCIA
Authors: Cartaxo Kellyane Moreira Lima Mariz , Lacerda Adriana dos Santos , Pires Valquiria Pinheiro Pereira , Drumond Clarissa Lopes , Oliveira Marcos Alexandre Casimiro de , Sousa Raulison Vieira de
Published: November 2024

Introdução: A classificação de risco tem como propósito identificar pacientes com potencial risco à vida e proporcionar um atendimento ágil e humanizado para casos graves. O atendimento com classificação de risco se baseia em um protocolo com linguagem universal e é conduzido por profissionais de saúde qualificados, como enfermeiros e médicos, visando determinar a gravidade do paciente e garantir um cuidado eficiente e seguro respaldado por evidências científicas. Os sintomas principais são relatados pelo paciente ao enfermeiro, e a partir dos sinais e sintomas observados, são utilizados para classificar a prioridade do atendimento clínico, a qual a preferência é designada por meio de cores. Objetivo: Analisar a luz da literatura a importância do enfermeiro na triagem de pacientes em unidades de emergência. Metodologia: Tratou-se de uma revisão de literatura, que foi realizada através da Biblioteca Virtual em Saúde (BVS), com dados das plataformas virtuais Base de dados de Enfermagem (BDENF), Literatura Latino-americana e do Caribe em Ciências Sociais e da Saúde (LILACS) e Brasil Scientific Electronic Library Online (SCIELO), utilizando os descritores “Triagem”, “Enfermagem" e "Emergência". Também conto com o uso do operador booleano “AND” para a combinação dos termos da pesquisa. Foram utilizados os seguintes critérios de inclusão: artigos completos, em português, inglês e espanhol, publicados nos últimos 5 anos, e foram excluídos trabalhos incompletos, teses, monografias e estudos que não fizeram parte da temática da proposta. Resultados : O enfermeiro é responsável por avaliar e classificar a gravidade dos pacientes em emergências, atribuindo um grau de risco que orienta o atendimento. Esse processo envolve escutar as reclamações, analisar o exame físico e usar protocolos para padronizar a classificação de risco. O primeiro contato é fundamental para determinar prioridades de assistência e garantir um atendimento de qualidade. Conclusão: Assim, a educação continuada e o aprimoramento das habilidades são essenciais para que os profissionais de enfermagem possam proporcionar um cuidado de excelência, focado nas necessidades dos pacientes e fundamentado em evidências, promovendo, dessa forma, o bem-estar e a saúde.
O PAPEL DO ENFERMEIRO NO GERENCIAMENTO DA TRIAGEM E CLASSIFICAÇÃO DE RISCO EM SERVIÇOS DE URGÊNCIA E EMERGÊNCIA: CONTRIBUIÇÕES E ORIENTAÇÃO AOS USUÁRIOS
Authors: Silva Thacya Kruschewsky Alves da , Santos Carlos Oliveira dos
Published: November 2024

O presente estudo teve como objetivo analisar a importância e o impacto da atuação do enfermeiro no processo de triagem e classificação de risco em serviços de urgência e emergência, focando na melhoria da qualidade do atendimento e na garantia de equidade. A triagem e a classificação de risco emergem como ferramentas essenciais para organizar o fluxo de pacientes, priorizando aqueles em situação de maior gravidade. A revisão bibliográfica revelou que a adoção de protocolos, como o Sistema de Triagem de Manchester (STM) e o Acolhimento com Classificação de Risco (ACCR), contribui significativamente para a eficiência dos serviços de saúde, reduzindo o tempo de espera e melhorando os desfechos clínicos. No entanto, a superlotação e a insuficiência de recursos nas unidades de saúde representam desafios contínuos para a implementação adequada dessas práticas. O estudo reforça a centralidade do papel do enfermeiro não apenas na execução técnica da triagem, mas também na humanização do atendimento. Conclui-se que a capacitação contínua dos enfermeiros, juntamente com o fortalecimento das políticas públicas, é essencial para otimizar o atendimento nas urgências e promover uma assistência mais equânime e humanizada.
O PAPEL DO CUIDADOR NA EDUCAÇÃO ESPECIAL INCLUSIVA
Authors: Farias Cláudia Cristiane Verçosa Simões de , Andrade Lucianne Oliveira Monteiro
Published: November 2024

Esse artigo buscou apresentar, a partir de uma pesquisa de doutorado, o papel e a contribuição dos cuidadores de estudantes da Educação Especial sob a perspectiva da Educação Inclusiva, focando nos desafios e nas oportunidades para a formação continuada desses profissionais na Rede Pública Municipal de Ensino de Dias d'Ávila, Bahia. O estudo foi realizado em duas escolas de referência, a Escola Municipal Madre Diamantina e a Escola Municipal Carlos Drummond de Andrade, que nucleiam outras oito instituições e envolvem 56 profissionais de diferentes áreas. A pesquisa buscou identificar os desafios enfrentados pelos cuidadores, o nível de formação e tempo de atuação, bem como os conhecimentos e dificuldades no exercício da função, além de sugestões para melhorar seu trabalho com os estudantes. Os resultados apontam a importância da Educação Inclusiva como responsabilidade coletiva e destacam a necessidade de políticas públicas que garantam o acesso igualitário à educação especial. A metodologia incluiu uma abordagem qualitativa, observação participante, questionários semiestruturados e análise de conteúdo. A conclusão enfatiza a urgência de formação continuada, normatização e investimentos para superar barreiras e promover a inclusão com qualidade e equidade.
A IMPORTÂNCIA DA CONTABILIDADE FINANCEIRA PARA AS MICRO E PEQUENAS EMPRESAS
Authors: Santos Stephanie Souza Almeida , Assis Pablo Roberto de
Published: November 2024

As micro e pequenas empresas assumem posição estratégica no cenário econômico, mas, frequentemente enfrentam desafios significativos de gestão financeira. Diante disso, a contabilidade financeira surge como uma ferramenta para melhorar a transparência, eficiência e desempenho desses negócios, proporcionando informações pertinentes para a tomada de decisões estratégicas. Posto isso, o objetivo da pesquisa foi investigar a importância da contabilidade financeira como ferramenta estratégica para a gestão das micro e pequenas empresas. A metodologia adotada foi uma revisão da literatura sobre contabilidade financeira para micro e pequenas empresas, utilizando bases de dados como SciELO e Google Acadêmico para identificar estudos relevantes. Foram revisados artigos, livros e outras publicações que abordam os princípios contábeis aplicados as micro e pequenas empresas, bem como suas práticas e desafios específicos. Os resultados indicam que a contabilidade financeira desempenha um papel crucial na gestão das micro e pequenas empresas, fornecendo informações precisas e atualizadas sobre a saúde financeira da empresa. As práticas contábeis adequadas permitem uma melhor análise de custos, margens de lucro, planejamento tributário e gestão de fluxo de caixa, essenciais para a tomada de decisões informadas. Conclui-se que a contabilidade financeira é grande importância e pode propiciar o crescimento das micro e pequenas empresas, permitindo uma gestão mais eficiente e estratégica.
A REDUÇÃO DA MAIORIDADE PENAL NO BRASIL
Authors: Santos Maria Eduarda Silva , Santos Wadan Franco Chaves dos , Dias Pauliana Maria
Published: November 2024

Este artigo analisa a questão da maioridade penal no Brasil, atualmente fixada aos 18 anos, e os potenciais impactos da sua redução para 16 ou até 14 anos. Através de uma abordagem histórica e jurídica, o estudo discute a evolução das políticas de proteção à infância e adolescência, a implementação do Estatuto da Criança e do Adolescente (ECA), as propostas de emenda à Constituição e as posições adotadas pelo Judiciário brasileiro. Considerando os argumentos favoráveis e contrários à redução da maioridade penal, o artigo avalia os impactos sociais, psicológicos e econômicos da possível responsabilização penal de jovens. A partir de uma revisão das experiências internacionais, a pesquisa busca contribuir para o debate, questionando a eficácia das políticas punitivas e enfatizando a necessidade de investimentos em educação, prevenção e reabilitação, como alternativa a medidas exclusivamente punitivas.
PENGARUH ETOS KERJA TERHADAP KINERJA PEGAWAI KANTOR KELURAHAN BERINGIN RAYA
Authors: Rahma Fatria  , Maria Elina  , Husna Purnama  , Hesti Widi Astuti  , Tedi Gunawan
Published: November 2024

Because human resources are a very important and indispensable organizational asset to achieve goals, such as the vision and mission of the organization, the role and function of human resources cannot be replaced by other resources. Kelurahan has duties and functions to carry out government tasks delegated by the sub-district head, as well as other government tasks stipulated by law.Kecamatan and kelurahan have a hierarchical working relationship. This study aims to determine how work ethic affects the performance of Beringin Raya employees, totaling 25 people. The results show that work ethic affects employee performance positively and significantly. Work ethic is defined as an attitude that has meaning as an evaluation component owned by individuals or groups in providing an assessment of work.
Kinetics of the reactions of OH with CO, NO, NO2 and of HO2 with NO2 in air at 1 atm pressure, room temperature and tropospheric water vapour concentrations
Authors: Rolletter Michael , Hofzumahaus Andreas , Novelli Anna , Wahner Andreas , Fuchs Hendrik
Published: November 2024

Abstract. The termolecular reactions of hydroxyl radicals (OH) with carbon monoxide (CO), nitric oxide (NO) and nitrogen dioxides (NO2) and the termolecular reaction of hydroperoxyl radicals (HO2) with NO2 greatly impact the atmospheric oxidation efficiency. Few studies have directly measured the pressure dependent rate coefficients in air at 1 atm pressure and water vapour as third collision partners. In this work, rate coefficients were measured with a high accuracy (<5 %) at 1 atm pressure, room temperature and in humidified air using laser flash photolysis and detection of the radical decay by laser-induced fluorescence. The rate coefficients derived in dry air are: (2.39±0.11) · 10-13 cm3 s-1 for the OH reaction with CO, (7.3±0.4) · 10-12 cm3 s-1 for the OH reaction with NO, (1.23±0.04) · 10-11 cm3 s-1 for the OH reaction with NO2, and (1.56±0.05) · 10-12 cm3 s-1 for the HO2 reaction with NO2. For the OH reactions with CO and NO, no dependence on water vapour was observed for the range of water partial pressures tested (3 to 22 hPa), and for NO2, only a weak increase of 3 % was measured in agreement with the study by Amedro et al. (2020). For the rate coefficient of HO2 with NO2 an enhancement of up to 25 % was observed. This can be explained by a faster rate coefficient of the reaction of the HO2-water complex with NO2 having a value of (3.4±1.1) · 10-12 cm3 s-1.
ВЛИЯНИЕ РЕЖИМОВ ИМПУЛЬСНОГО ТОКА ПРИ ИЗГИБЕ ТИТАНОВОГО СПЛАВА
Authors: О.Е. Корольков , У.Х. Угурчиев , Н.Н. Новикова
Published: November 2024

В статье рассмотрены режимы электропластической деформации титанового сплава ВТ6 с помощью трехточечного изгиба с последующим применением найденных режимов для деформации заготовки имплантата. Оценено влияние плотности тока и длительности импульса при постоянной скважности. Для оценки электропластического эффекта, тепловой вклад тока сравнивался с разогревом от внешнего источника.

The aim of the work is to find modes of electroplastic deformation of titanium alloy VT6 using three-point bending with subsequent application of the found modes for deformation of the implant blank. The influence of current density and pulse duration at a constant duty cycle is estimated. To evaluate the EPE, the thermal contribution of the current was compared with the heating from an external source.
The Role of C - Reactive protein in Inflammatory Diseases: Insights from a Mini-Review.
Authors:   Department of Biochemistry,, Wangsu Thakngam , Phukan Dr. Jadab kishore ,   Department of Biochemistry
Published: November 2024

C-reactive protein, or CRP, is a well-known biomarker
for inflammation and plays a crucial role in the immune
response of the body. The clinical use of CRP in the diagnosis
and treatment of inflammatory illnesses, such as infections,
rheumatoid arthritis, and cardiovascular disorders, is
examined in this mini-review. We go through the biochemical
characteristics of CRP, how it contributes to inflammation,
and how CRP levels affect clinical practice.
Analysis of Sex Hormones and AMH Correlated With COVID-19 in Women of Reproductive Age: An Observational Study.
Authors: Yin Lijun , He Weihua ,   Department of Obstetrics and Gynecology, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China,310003, Xie Guoliang ,   Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China,310003, Alhaskawi Ahmad , Dong Yanzhao , Lu Hui ,   Department of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China,310003, Wang Zewei , Yao Chengjun ,   Zhejiang University School of Medicine, #866 Yuhangtang Road, Hangzhou, Zhejiang Province, P. R. China, 3100058, Liu Olga ,   Department of Neurology, Republican Research and Clinical Center of Neurology and Neurosurgery, Minsk, Belarus., Abdalbary Sahar Ahmed ,   Department of Orthopedic Physical Therapy, Faculty of Physical Therapy, Nahda University, Beni Suef, Egypt., Liu Zhenfeng ,   Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China, 3100058.
Published: November 2024

COVID-19 is currently one of the most widespread infectious
diseases globally. The goal of this research is to present a
new understanding regarding the connection between SARSCoV-2 and ovarian activity among women of childbearing
age. In this observational study, clinical information from 218
women who were infected with SARS-CoV-2 was analyzed
retrospectively. The relationship between the severity of the
disease and sex hormone levels is analyzed and compared.
E2 and T levels showed a significant downward trend with
the aggravation of COVID-19 disease, and the difference
was significant (P=0.000286, P=0.009). FSH and LH were
not significantly affected(P=0.184, P=0.129), although they
appeared to decline with disease progression. There were
no significant P-values for age, prolactin and progesterone,
AMH levels, and FSH/LH in the three groups of patients, with
P=0.096, P=0.341, P=0.12, P=0.542, P=0.636, respectively.
The significantly reduced E2 and T levels in the severely
infected group suggest that SARS-CoV-2 may affect glands
and related hormones directly or indirectly. The AMH showed
no significant change, indicating that comprehensive ovarian
reserve function was not affected in the short term, but longterm follow-up observation is required.
Ideology and Theoretical Narratives in Economics
Authors: Volchik Vyacheslav , Fursa Elena
Published: November 2024

The article develops narrative economics approaches to analyzing ideology as an important component of theoretical narratives in economic science. On the one hand, many economists cannot eliminate the influence of ideology on scientific research. On the other hand, ideology continues to be considered as something that rather hinders objective scientific research. However, through the prism of mental models, ideologies directly related to actors' collective and individual interests form a worldview relevant to adherents of a particular ideological position or attitude. In this article, the authors offer a working definition of ideology based on North's approach to defining ideology. Ideologies are shared mental models for groups of individuals. Through mental models, groups of individuals explain the supposed and real connections between means and results for implementing policies aimed at transforming society. Of key importance are groups of individuals (scientific schools, political organizations, etc.) and their actions to establish and promote supposed or real connections between means and results. Ideology in social sciences often takes the form of theoretical narratives, one of the research narratives used in narrative economics. The theoretical narrative in economic theory differs significantly from the narratives linguists work with. For economists who use the concept of narrative, first of all, it is essential to know what ideas, morals or rules are transmitted along with history or narrative. Here, it is vital to understand how theoretical components or simplified models are related to historical or national contexts. Theoretical narratives are either closely related to or include elements of historical narratives. Together with theoretical ones, historical narratives allow us to reconstruct and create explanations of critical historical events to promote a particular ideological agenda. Using the ideologies of socialism and neoliberalism as an example, the authors examine theoretical narratives that have an ideological component and are used to justify the economic policy and explain important development patterns of the Russian economic order.
ОСОБЕННОСТИ РАЗРУШЕНИЯ С РАСЩЕПЛЕНИЯМИ НИЗКОУГЛЕРОДИСТОЙ МИКРОЛЕГИРОВАННОЙ МОРСКОЙ СТАЛИ S460MLO ПРИ ИСПЫТАНИЯХ НА РАСКРЫТИЕ ТРЕЩИНЫ
Authors: Е.А. Голи-Оглу , А.Н. Филатов
Published: November 2024

С использованием результатов испытаний промышленных партий проката толщиной 23 мм после термомеханической прокатки с последующей постсварочной термической обработкой проанализированы закономерности формирования расщеплений в изломах образцов при проведении CTOD-испытаний на раскрытие трещины. Выполнены визуальные, микроструктурные и фрактографические исследования характера разрушения изломов и поверхности образовавшихся вторичных расщеплений. Описаны вероятные причины проявления потенциального «pop-in» эффекта на диаграммах «нагрузка – раскрытие берегов надреза» и его потенциально негативного влияния на интерпретацию результатов испытаний.

Using the results of testing industrial batches of 23 mm steel heavy plates after thermomechanical rolling and subsequent post-weld heat treatment, the patterns of fatigue cracks formation in the fracture specimens during CTOD (Crack Tip Opening Displacement) testing for fracture toughness are investigated. Visual, microstructural, and fractographic studies have been conducted on the nature of fracture formation and fatigue crack propagation mechanisms. The probable causes of the manifestation of the potential «pop-in» effect on the load-displacement diagrams of the notch opening displacement are described, as well as its potentially negative impact on the interpretation of test results.
МОДЕЛИ ОПТИМАЛЬНОЙ УПАКОВКИ В ЗАДАЧАХ ОПРЕДЕЛЕНИЯ ПОРИСТОСТИ ОКУСКОВАННЫХ ПРОДУКТОВ
Authors: А.М. Бижанов
Published: November 2024

В статье с позиций теории упаковки сфер изучено влияние гранулометрического состава материала на пористость брикетов и окатышей, а также фракционного состава окускованных продуктов на порозность слоев из таких шихтовых компонентов. Знание закономерностей изменения пористости окускованного продукта при варьировании гранулометрии исходного материала позволяет оптимизировать металлургические свойства брикета и окатышей. Порозность слоя таких продуктов во многом определяет их поведение как в процессах восстановления (в доменных и руднотермических печах, в реакторах прямого восстановления), так и при обжиге окатышей. Полученные результаты позволили впервые выявить локальные экстремумы пористости окускованных продуктов и порозности слоя окатышей (брикетов). Разработанный эвристический подход может быть использован в задачах выбора оптимального состава смесей для окускования и повышения эффективности обжига окатышей и достижения высоких степеней металлизации при восстановлении окускованной шихты. Методология предложенного подхода позволяет учитывать сжимаемость и неоднородность формы как частиц исходной смеси, так и самих окускованных продуктов.

In the article, from the standpoint of the theory of sphere packing, the influence of the granulometric composition of the material on the porosity of briquettes and pellets, and the fractional composition of agglomerated products on the porosity of layers of such charge components is studied. Knowledge of the patterns of changes in the porosity of the agglomerated product when varying the granulometry of the starting material makes it possible to optimize the metallurgical properties of the briquette and pellets. The porosity of the layer of such products largely determines their behavior both in reduction processes (in blast furnaces and ore furnaces, in direct reduction reactors) and during pellet roasting. The results obtained made it possible for the first time to identify local extrema in the porosity of agglomerated products and the porosity of the layer of pellets (briquettes). The developed heuristic approach can be used in the problems of selecting the optimal composition of mixtures for agglomeration and increasing the efficiency of pellet firing and achieving high degrees of metallization when restoring the agglomerated charge. The methodology of the proposed approach makes it possible to take into account the compressibility and heterogeneity of the shape of both the particles of the initial mixture and the agglomerated products themselves.
Case report: The use of Venovenous Extracorporeal Membrane Oxygenation in the Treatment of Acute Respiratory Distress Syndrome in Severe Leptospirosis
Authors: Silva Neto Fernando de Oliveira e , Diniz Renan Gomes Mendes , Chagas Gabriel Cavalcante Lima , Felix Helen Melo Oliveira , Ximenes Ana Larissa Pedrosa , Carvalho Bráulio Matias de , Oliveira Fátima Rosane de Almeida , Trompieri Daniel Francisco de Mendonça , Meija Juan Alberto Casquillo , Andrade Lucia da Conceição , Daher Elizabeth de Francesco
Published: November 2024

Leptospirosis is a globally distributed zoonosis with a clinical spectrum ranging from mild febrile illness to life-threatening disease, that can result in acute kidney injury (AKI) and severe pulmonary complications such as alveolar hemorrhage and acute respiratory distress syndrome (ARDS). We present the case of a 20-year-old man with fever and respiratory distress, diagnosed with ARDS and AKI. Venovenous (VV), extracorporeal membrane oxygenation (ECMO) and sustained low-efficiency daily dialysis (SLED) were initiated. The patient showed significant respiratory improvement after eight days and renal recovery after seventeen days. Leptospirosis serological conversion confirmed the diagnosis. This case highlights the potential of VV ECMO as an effective supportive therapy in severe respiratory failure secondary to leptospirosis. Early recognition and aggressive management, including ECMO and daily dialysis, may enhance outcomes in severe pulmonary leptospirosis.
Sleep Disturbances in Parkinson's Disease: A Scoping Review
Authors: Naia Carolina Vieira , Faria Giovana de Souza , Filho Flávio de Lima , Dionísio Artur Consulo , Oliveira Luana Passos , Guizardi Marissa Prudente Pinheiro , Aguiar Marina Feitosa de Castro , Santos Júlio César Claudino dos , Stangherlin Luana
Published: November 2024

Neurodegenerative diseases (ND), such as Parkinson's disease (PD) and Alzheimer's disease (AD), are characterized by progressive neuronal loss and degeneration, leading to both motor and non-motor symptoms, including sleep disturbances. Sleep disorders are highly prevalent in PD, affecting between 60% and 98% of patients. These include insomnia, excessive daytime sleepiness (EDS), sleep-disordered breathing, obstructive sleep apnea (OSA), restless legs syndrome (RLS), circadian rhythm disorders, and REM sleep behavior disorder (RBD). This article provides a comprehensive literature review on the pathophysiology, diagnosis, and management of sleep disorders in patients with PD. We highlight the significant impact these disturbances have on quality of life and emphasize the importance of regular screening and individualized treatment plans. Additionally, we discuss the challenges posed by non-motor symptoms in PD, particularly those related to sleep, as they often do not respond well to traditional dopaminergic therapies. Future research should aim to enhance diagnostic techniques and develop more targeted, patient-centered interventions to improve the management of sleep disorders in PD.