bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure Legend from A Single Nucleotide Polymorphism in Inflammatory Gene RNASEL Predicts Outcome after Radiation Therapy for Localized Prostate Cancer
Authors: Schoenfeld Jonathan D. , Margalit Danielle N. , Kasperzyk Julie L. , Shui Irene M. , Rider Jennifer R. , Epstein Mara M. , Meisner Allison , Kenfield Stacey A. , Martin Neil E. , Nguyen Paul L. , Kantoff Philip W. , Giovannucci Edward L. , Stampfer Meir J. , Mucci Lorelei A.
Published: April 2023

PDF file - 46K
Supplementary Figure 2 from A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors
Authors: Rodon Jordi , Tawbi Hussein A. , Thomas Anne L. , Stoller Ronald G. , Turtschi Christian P. , Baselga Jose , Sarantopoulos John , Mahalingam Devalingam , Shou Yaping , Moles Melissa A. , Yang Lin , Granvil Camille , Hurh Eunju , Rose Kristine L. , Amakye Dereck D. , Dummer Reinhard , Mita Alain C.
Published: April 2023

PDF file - 79K, Mean sonidegib plasma concentration-time profiles after single oral administration on day 1 of the pharmacokinetic run-in period before initiation of continuous dosing.
Supplementary Table 1 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Authors: Hamidi Tewfik , Cano Carla E. , Grasso Daniel , Garcia Maria Noé , Sandi Maria José , Calvo Ezequiel L. , Dagorn Jean-Charles , Lomberk Gwen , Urrutia Raul , Goruppi Sandro , Carracedo Arkaitz , Velasco Guillermo , Iovanna Juan L.
Published: April 2023

PDF file, 57K, siRNA sequences used for silencing Nupr1, Beclin1, ATG5 and AURKA mRNA and Primer sequences used to amplify human genes.
Supplementary Figure Legend from Systematic Kinome shRNA Screening Identifies CDK11 (PITSLRE) Kinase Expression Is Critical for Osteosarcoma Cell Growth and Proliferation
Authors: Duan Zhenfeng , Zhang Jianming , Choy Edwin , Harmon David , Liu Xianzhe , Nielsen Petur , Mankin Henry , Gray Nathanael S. , Hornicek Francis J.
Published: April 2023

PDF file, 80K.
Supplementary Figure 3 from Systematic Kinome shRNA Screening Identifies CDK11 (PITSLRE) Kinase Expression Is Critical for Osteosarcoma Cell Growth and Proliferation
Authors: Duan Zhenfeng , Zhang Jianming , Choy Edwin , Harmon David , Liu Xianzhe , Nielsen Petur , Mankin Henry , Gray Nathanael S. , Hornicek Francis J.
Published: April 2023

PDF file, 31K, Validation of CDK11 knockdown inhibits proliferation and growth in multiple osteosarcoma cell lines.
Supplementary Figure 3 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Authors: Hamidi Tewfik , Cano Carla E. , Grasso Daniel , Garcia Maria Noé , Sandi Maria José , Calvo Ezequiel L. , Dagorn Jean-Charles , Lomberk Gwen , Urrutia Raul , Goruppi Sandro , Carracedo Arkaitz , Velasco Guillermo , Iovanna Juan L.
Published: April 2023

PDF file, 192K, Nupr1 is required to maintain DNA repair activity in response to hypoxia and glucose starvation.
Supplementary Figure 2 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Authors: Hamidi Tewfik , Cano Carla E. , Grasso Daniel , Garcia Maria Noé , Sandi Maria José , Calvo Ezequiel L. , Dagorn Jean-Charles , Lomberk Gwen , Urrutia Raul , Goruppi Sandro , Carracedo Arkaitz , Velasco Guillermo , Iovanna Juan L.
Published: April 2023

PDF file, 232K, Predicted pathways regulated by Nupr1.
Supplementary Table 4 from TGF-β–Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12
Authors: Fan Yu , Shen Bing , Tan Mingyue , Mu Xinyu , Qin Yan , Zhang Fang , Liu Yong
Published: April 2023

PDF file - 63K, Multivariate Cox regression analysis for overall survival of patients with bladder cancer.
Supplementary Table 1 from TGF-β–Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12
Authors: Fan Yu , Shen Bing , Tan Mingyue , Mu Xinyu , Qin Yan , Zhang Fang , Liu Yong
Published: April 2023

PDF file - 140K, Associations of malat1 expression with clinical pathologic features in patients with bladder cancer.
CCR Translation for This Article from Stromal Responses among Common Carcinomas Correlated with Clinicopathologic Features
Authors: Chen Julia L-Y. , Espinosa Iñigo , Lin Albert Y. , Liao Olivia Y-W. , van de Rijn Matt , West Robert B.
Published: April 2023

CCR Translation for This Article from Stromal Responses among Common Carcinomas Correlated with Clinicopathologic Features
Supplementary Figure 1 from TGF-β–Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12
Authors: Fan Yu , Shen Bing , Tan Mingyue , Mu Xinyu , Qin Yan , Zhang Fang , Liu Yong
Published: April 2023

PDF file - 133K, TGF-beta treatment increases N-cadherin and fibronectin mRNA level.
Supplementary Table 1 from Identifying and Targeting ROS1 Gene Fusions in Non–Small Cell Lung Cancer
Authors: Davies Kurtis D. , Le Anh T. , Theodoro Mariana F. , Skokan Margaret C. , Aisner Dara L. , Berge Eamon M. , Terracciano Luigi M. , Cappuzzo Federico , Incarbone Matteo , Roncalli Massimo , Alloisio Marco , Santoro Armando , Camidge D. Ross , Varella-Garcia Marileila , Doebele Robert C.
Published: April 2023

PDF file - 35K, Primer sequences used for PCR in this study
Supplementary Figure 2 from Temozolomide Does Not Impair Gene Therapy-Mediated Antitumor Immunity in Syngeneic Brain Tumor Models
Authors: Candolfi Marianela , Yagiz Kader , Wibowo Mia , Ahlzadeh Gabrielle E. , Puntel Mariana , Ghiasi Homayon , Kamran Neha , Paran Christopher , Lowenstein Pedro R. , Castro Maria G.
Published: April 2023

PDF file - 2705K, Efficacy of TMZ in combination with Ad-Flt3L in intracranial astrocytoma and melanoma models.
Supplementary Figure 1 from Identifying and Targeting ROS1 Gene Fusions in Non–Small Cell Lung Cancer
Authors: Davies Kurtis D. , Le Anh T. , Theodoro Mariana F. , Skokan Margaret C. , Aisner Dara L. , Berge Eamon M. , Terracciano Luigi M. , Cappuzzo Federico , Incarbone Matteo , Roncalli Massimo , Alloisio Marco , Santoro Armando , Camidge D. Ross , Varella-Garcia Marileila , Doebele Robert C.
Published: April 2023

PDF file - 68K, Micrographs of H&E and IHC of two squamous cell ROS1 positive cases
Supplementary Figure 5 from Ethacrynic Acid and a Derivative Enhance Apoptosis in Arsenic Trioxide–Treated Myeloid Leukemia and Lymphoma Cells: The Role of Glutathione S-Transferase P1-1
Authors: Wang Rui , Liu Changda , Xia Lijuan , Zhao Guisen , Gabrilove Janice , Waxman Samuel , Jing Yongkui
Published: April 2023

PDF file - 112K, Knock-down of catalase in K562 cells
Supplementary Table 1 from Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer
Authors: Amatu Alessio , Sartore-Bianchi Andrea , Moutinho Catia , Belotti Alessandro , Bencardino Katia , Chirico Giuseppe , Cassingena Andrea , Rusconi Francesca , Esposito Anna , Nichelatti Michele , Esteller Manel , Siena Salvatore
Published: April 2023

PDF file - 53K, Supplementary table 1 showing toxicities
Supplementary Table 1 from Targeting of 111In-Labeled Dendritic Cell Human Vaccines Improved by Reducing Number of Cells
Authors: Aarntzen Erik H.J.G. , Srinivas Mangala , Bonetto Fernando , Cruz Luis J. , Verdijk Pauline , Schreibelt Gerty , van de Rakt Mandy , Lesterhuis W. Joost , van Riel Maichel , Punt Cornelius J.A. , Adema Gosse J. , Heerschap Arend , Figdor Carl G. , Oyen Wim J. , de Vries I. Jolanda M.
Published: April 2023

PDF file - 62K, This table describes patient details, including disease state and prior treatments.
Supplementary Tables 9 - 10 from Differences in the Transcriptional Response to Fulvestrant and Estrogen Deprivation in ER-Positive Breast Cancer
Authors: Patani Neill , Dunbier Anita K. , Anderson Helen , Ghazoui Zara , Ribas Ricardo , Anderson Elizabeth , Gao Qiong , A'hern Roger , Mackay Alan , Lindemann Justin , Wellings Robert , Walker Jill , Kuter Irene , Martin Lesley-Ann , Dowsett Mitch
Published: April 2023

PDF file - 127KB, S9: Fold-changes and statistical significance of genes significantly and differentially affected by fulvestrant and E-deprivation in pre-surgical studies and in vitro models: (a) Up-regulated and (b) Down-regulated. Probes are annotated with gene symbols where available; S10: GO functional gene sets significantly and differentially affected by fulvestrant and E-deprivation in pre-surgical studies and in vitro models: (a) Up-regulated and (b) Down-regulated.
Supplementary Figure 3 from The Prognostic Significance and Therapeutic Potential of Hedgehog Signaling in Intrahepatic Cholangiocellular Carcinoma
Authors: Tang Liang , Tan Ye-Xiong , Jiang Bei-Ge , Pan Yu-Fei , Li Shuang-Xi , Yang Guang-Zhen , Wang Min , Wang Qing , Zhang Jian , Zhou Wei-Ping , Dong Li-Wei , Wang Hong-Yang
Published: April 2023

PDF file - 224K, Immunohistochemical staining of Shh, Gli1, and Gli2 in intrahepatic cholangiocellular carcinoma and normal liver tissues.
Supplementary Table 1 from Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia
Authors: Ouillette Peter , Saiya-Cork Kamlai , Seymour Erlene , Li Cheng , Shedden Kerby , Malek Sami N.
Published: April 2023

XLSX file - 195K, Listing of gene mutations and aCNA/LOH/cn-LOH in 156 CLL samples analyzed at enrollment and at longitudinal time points.
Supplementary Figure 2 from Highly Specific Targeting of the TMPRSS2/ERG Fusion Gene Using Liposomal Nanovectors
Authors: Shao Longjiang , Tekedereli Ibrahim , Wang Jianghua , Yuca Erkan , Tsang Susan , Sood Anil , Lopez-Berestein Gabriel , Ozpolat Bulent , Ittmann Michael
Published: April 2023

PDF file - 8094K, Representative images of NFκB p65 phospho-Ser536 immunohistochemistry from VCaP xenograft tumors treated with scrambled control SiRNA or targeted SiRNAs (Si8 or Si14). Original magnification: 400X.
Supplementary Table 3 from A Panel of Three Markers Hyper- and Hypomethylated in Urine Sediments Accurately Predicts Bladder Cancer Recurrence
Authors: Su Sheng-Fang , de Castro Abreu André Luís , Chihara Yoshitomo , Tsai Yvonne , Andreu-Vieyra Claudia , Daneshmand Siamak , Skinner Eila C. , Jones Peter A. , Siegmund Kimberly D. , Liang Gangning
Published: April 2023

PDF file - 68KB, Association between the score from the three-marker signature and the primary bladder tumor pathological characteristics of 90 TURBT patients.
Supplementary Table 1 from A Panel of Three Markers Hyper- and Hypomethylated in Urine Sediments Accurately Predicts Bladder Cancer Recurrence
Authors: Su Sheng-Fang , de Castro Abreu André Luís , Chihara Yoshitomo , Tsai Yvonne , Andreu-Vieyra Claudia , Daneshmand Siamak , Skinner Eila C. , Jones Peter A. , Siegmund Kimberly D. , Liang Gangning
Published: April 2023

PDF file - 76KB, DNA methylation status in urine sediment samples of TURBT patients at the time of first recurrence and the last follow-up visit of no recurrence patients.
Supplementary Figure 1 from Synergy of Topical Toll-like Receptor 7 Agonist with Radiation and Low-Dose Cyclophosphamide in a Mouse Model of Cutaneous Breast Cancer
Authors: Dewan M. Zahidunnabi , Vanpouille-Box Claire , Kawashima Noriko , DiNapoli Sara , Babb James S. , Formenti Silvia C. , Adams Sylvia , Demaria Sandra
Published: April 2023

PDF file - 69K, Supplementary Figure 1. Response of TSA cells to imiquimod in vitro. TSA cells were cultured in the presence of imiquimod or vehicle control at the indicated concentrations in triplicate wells. Data are expressed as percentage viable cells compared to control � SD. Errors bars are present but were very small. Data are representative of two independent experiments.
Supplementary Figure 4 from A Panel of Three Markers Hyper- and Hypomethylated in Urine Sediments Accurately Predicts Bladder Cancer Recurrence
Authors: Su Sheng-Fang , de Castro Abreu André Luís , Chihara Yoshitomo , Tsai Yvonne , Andreu-Vieyra Claudia , Daneshmand Siamak , Skinner Eila C. , Jones Peter A. , Siegmund Kimberly D. , Liang Gangning
Published: April 2023

PDF file - 348KB, Three DNA methylation markers help predict the risk of recurrence of bladder tumors in urine sediments.
Supplementary Figure 1 from Impact of Tumor Microenvironment and Epithelial Phenotypes on Metabolism in Breast Cancer
Authors: Brauer Heather Ann , Makowski Liza , Hoadley Katherine A. , Casbas-Hernandez Patricia , Lang Lindsay J. , Romàn-Pèrez Erick , D'Arcy Monica , Freemerman Alex J. , Perou Charles M. , Troester Melissa A.
Published: April 2023

PDF file - 102K, Glucose metabolism is elevated in basal-like breast cancer with lactate production increasing with stroma presence. Glucose uptake, oxidation, and glycogen synthesis in increased in breast cancer cells (MCF7 and SUM149) when compared to CAFs (LCAF and BCAF) as shown in A. However, SUM149, basal-like breast cancer cells, exhibit higher levels of glucose metabolism than MCF7, luminal cells (A). Lactate production is increased in all coculture conditions regardless of luminal or basal-like epithelial or fibroblast cells (B).
Supplementary Figure 3 from A Panel of Three Markers Hyper- and Hypomethylated in Urine Sediments Accurately Predicts Bladder Cancer Recurrence
Authors: Su Sheng-Fang , de Castro Abreu André Luís , Chihara Yoshitomo , Tsai Yvonne , Andreu-Vieyra Claudia , Daneshmand Siamak , Skinner Eila C. , Jones Peter A. , Siegmund Kimberly D. , Liang Gangning
Published: April 2023

PDF file - 97KB, Receiver operating characteristic (ROC) curves of the three-marker signature in detecting tumor recurrence.
Supplementary Figure 1 from A Panel of Three Markers Hyper- and Hypomethylated in Urine Sediments Accurately Predicts Bladder Cancer Recurrence
Authors: Su Sheng-Fang , de Castro Abreu André Luís , Chihara Yoshitomo , Tsai Yvonne , Andreu-Vieyra Claudia , Daneshmand Siamak , Skinner Eila C. , Jones Peter A. , Siegmund Kimberly D. , Liang Gangning
Published: April 2023

PDF file - 88KB, DNA methylation alterations can be detected in urine sediment samples from patients with bladder cancer.
Supplementary Figure Legends from Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non–Small Cell Lung Cancer
Authors: Yoshida Takeshi , Zhang Guolin , Smith Matthew A. , Lopez Alex S. , Bai Yun , Li Jiannong , Fang Bin , Koomen John , Rawal Bhupendra , Fisher Kate J. , Chen Ann Y. , Kitano Michiko , Morita Yume , Yamaguchi Haruka , Shibata Kiyoko , Okabe Takafumi , Okamoto Isamu , Nakagawa Kazuhiko , Haura Eric B.
Published: April 2023

PDF file - 153KB
Supplementary Table 6 from Phase Ib Study of Buparlisib plus Trastuzumab in Patients with HER2-Positive Advanced or Metastatic Breast Cancer That Has Progressed on Trastuzumab-Based Therapy
Authors: Saura Cristina , Bendell Johanna , Jerusalem Guy , Su Shaun , Ru Qinhua , De Buck Stefan , Mills David , Ruquet Sophie , Bosch Ana , Urruticoechea Ander , Beck Joseph T. , Di Tomaso Emmanuelle , Sternberg David W. , Massacesi Cristian , Hirawat Samit , Dirix Luc , Baselga Jose
Published: April 2023

PDF file - 62K, Summary of buparlisib pharmacokinetic parameters.
Supplementary Figure 7 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors
Authors: Bladt Friedhelm , Faden Bettina , Friese-Hamim Manja , Knuehl Christine , Wilm Claudia , Fittschen Claus , Grädler Ulrich , Meyring Michael , Dorsch Dieter , Jaehrling Frank , Pehl Ulrich , Stieber Frank , Schadt Oliver , Blaukat Andree
Published: April 2023

PDF file - 54K, Dose-dependent induction of caspase-3 cleavage by EMD 1204831. Mice bearing established (100-200mm3) Hs746T tumors received a single dose of 3, 10, 30, and 100 mg/kg of EMD 1204831. The effects on caspase-3 activation were determined by Western blot analyses, using an antibody (clone 5A1E) specifically recognizing the large fragment (17/19 kDa) of activated caspase-3 resulting from cleavage adjacent to Asp 175. This antibody does not recognize full-length caspase-3 or other cleaved caspases. Treatment with EMD 1204831 resulted in a transient increase in cleaved caspase-3 that peaked at 24 h and declined at 48 h. Data are representative of three separate experiments.
Supplementary Figure 6 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors
Authors: Bladt Friedhelm , Faden Bettina , Friese-Hamim Manja , Knuehl Christine , Wilm Claudia , Fittschen Claus , Grädler Ulrich , Meyring Michael , Dorsch Dieter , Jaehrling Frank , Pehl Ulrich , Stieber Frank , Schadt Oliver , Blaukat Andree
Published: April 2023

PDF file - 55K, Effective reduction of c-Met phosphorylation by EMD 1214063 in KP-4 pancreatic carcinoma tumors. To assess the pharmacodynamic effect of EMD 1214063 on pancreatic carcinoma, KP-4 tumors were obtained ex vivo at the indicated time points after treatment with 5 mg/kg EMD 1214063, lysed, and subsequently analyzed for the levels of total c-Met and c-Met phosphorylation at the Y1234/Y1235 auto-phosphorylation site and at the Y1349 adaptor binding site by a Luminex-based assay. Phosphorylation of both Y1234/Y1235 and Y1349 sites were markedly reduced between 2-6 h after treatment, in the absence of any significant changes in the levels of total c-Met. Data are representative of two separate experiments.
Supplementary Figure 1 from Phase Ib Study of Buparlisib plus Trastuzumab in Patients with HER2-Positive Advanced or Metastatic Breast Cancer That Has Progressed on Trastuzumab-Based Therapy
Authors: Saura Cristina , Bendell Johanna , Jerusalem Guy , Su Shaun , Ru Qinhua , De Buck Stefan , Mills David , Ruquet Sophie , Bosch Ana , Urruticoechea Ander , Beck Joseph T. , Di Tomaso Emmanuelle , Sternberg David W. , Massacesi Cristian , Hirawat Samit , Dirix Luc , Baselga Jose
Published: April 2023

PDF file - 67K, Bayesian logistic regression model: dose-response curve and model inference results at the time of determination of the recommended Phase II dose.
Supplementary Table 2 from microRNAome Expression in Chronic Lymphocytic Leukemia: Comparison with Normal B-cell Subsets and Correlations with Prognostic and Clinical Parameters
Authors: Negrini Massimo , Cutrona Giovanna , Bassi Cristian , Fabris Sonia , Zagatti Barbara , Colombo Monica , Ferracin Manuela , D'Abundo Lucilla , Saccenti Elena , Matis Serena , Lionetti Marta , Agnelli Luca , Gentile Massimo , Recchia Anna Grazia , Bossio Sabrina , Reverberi Daniele , Rigolin Gianmatteo , Calin George A. , Sabbioni Silvia , Russo Giandomenico , Tassone Pierfrancesco , Morabito Fortunato , Ferrarini Manlio , Neri Antonino
Published: April 2023

XLSX file - 248K, microRNAs exhibiting differential expression between CLL and normal antigen-experienced B cells.
Supplementary Figure 2 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors
Authors: Bladt Friedhelm , Faden Bettina , Friese-Hamim Manja , Knuehl Christine , Wilm Claudia , Fittschen Claus , Grädler Ulrich , Meyring Michael , Dorsch Dieter , Jaehrling Frank , Pehl Ulrich , Stieber Frank , Schadt Oliver , Blaukat Andree
Published: April 2023

PDF file - 263K, Effects of EMD 1214063 on c-Met phosphorylation and downstream signaling molecules (see Figure 2C). EBC-1 cells were cultured in vitro in control medium (medium + vehicle) (lane 1), or in the presence of increasing concentrations of EMD 1214063 (A-D) or EMD 1204831(E-H) (0.01nM to 30�M, as depicted in lanes 2-15). Upon cell lysis, the levels of total c-Met, AKT, p42/44 MAPK (A, E), Gab1 (C, G), as well as phospho-c-Met, phospho-Akt, phospho-p42/44 MAPK (B, F), and phospho-Gab1 (D, H) were assessed by Western blot analyses. The levels of cofilin were used to ascertain equal loading (A, B, and F). Marked reductions in the levels of c-Met phosphorylation were observed for EMD 1214063 and EMD 1204831 at concentrations ≥0.1 �M (lanes 10-15). Data are representative of two independent experiments; cumulative results are shown in Fig. 2C.
Supplementary Methods from SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival
Authors: Hassanein Mohamed , Hoeksema Megan D. , Shiota Masakazu , Qian Jun , Harris Bradford K. , Chen Heidi , Clark Jonathan E. , Alborn William E. , Eisenberg Rosana , Massion Pierre P.
Published: April 2023

PDF file - 164K
Supplementary Figure 4 from SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival
Authors: Hassanein Mohamed , Hoeksema Megan D. , Shiota Masakazu , Qian Jun , Harris Bradford K. , Chen Heidi , Clark Jonathan E. , Alborn William E. , Eisenberg Rosana , Massion Pierre P.
Published: April 2023

PDF file - 20K, Inhibition of SLC1A5 activity reduces Gln uptake and cell growth of NSCLC cells
Supplementary Figure 2 from Network Analysis Identifies an HSP90-Central Hub Susceptible in Ovarian Cancer
Authors: Liu Hanqing , Xiao Fang , Serebriiskii Ilya G. , O'Brien Shane W. , Maglaty Marisa A. , Astsaturov Igor , Litwin Samuel , Martin Lainie P. , Proia David A. , Golemis Erica A. , Connolly Denise C.
Published: April 2023

PDF file - 139KB, Network showing direct physical interactions between HSP90 and 53 of the 171 highly sensitizing proteins.
Supplementary Video 5 from Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer
Authors: Amornphimoltham Panomwat , Rechache Kamil , Thompson Jamie , Masedunskas Andrius , Leelahavanichkul Kantima , Patel Vyomesh , Molinolo Alfredo , Gutkind J. Silvio , Weigert Roberto
Published: April 2023

MOV file - 4354K, Rab25 expression affects F-actin organization at the plasma membrane
Supplementary Figure 1 from Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer
Authors: Amornphimoltham Panomwat , Rechache Kamil , Thompson Jamie , Masedunskas Andrius , Leelahavanichkul Kantima , Patel Vyomesh , Molinolo Alfredo , Gutkind J. Silvio , Weigert Roberto
Published: April 2023

PDF file - 921K, A. Representative core tissues from human oral cancer tissue array stained using an antibody directed against human CLIC3. Quantitative analysis of the CLIC3 expression. ns = not statistically significant ; t-test ; p values > 0.05, n= number of tissue cores, Normal, T1, T2, T3, T4 = TNM classification at T1 and T2,T3 and T4 respectively. B. Representative core tissues from human cervical cancer tissue array stained with Hematoxylin-Eosin or using an antibody against human Rab25. Quantitative staining score of the Rab25 expression at low, medium and high scores are shown.
Supplementary Figure 1 from CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27− Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian Cancer
Authors: Nielsen Julie S. , Sahota Rob A. , Milne Katy , Kost Sara E. , Nesslinger Nancy J. , Watson Peter H. , Nelson Brad H.
Published: April 2023

PDF file, 56KB, B cells in HGSC tumors exhibit oligoclonal and somatically hypermutated immunoglobulin sequence.
Supplementary Table 17 from Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations
Authors: George Joshy , Alsop Kathryn , Etemadmoghadam Dariush , Hondow Heather , Mikeska Thomas , Dobrovic Alexander , deFazio Anna , Smyth Gordon K. , Levine Douglas A. , Mitchell Gillian , Bowtell David D.
Published: April 2023

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Supplementary Figures from PI3K Pathway Dependencies in Endometrioid Endometrial Cancer Cell Lines
Authors: Weigelt Britta , Warne Patricia H. , Lambros Maryou B. , Reis-Filho Jorge S. , Downward Julian
Published: April 2023

Supplementary Figures - PDF file 947K, Supplementary Figure 1. Targeted drug response curves of endometrial cancer cells. Endometrial cancer cell lines were incubated with serial dilutions of the targeted therapeutics tested and after 72h cell viability was assessed using CellTiter Blue; Supplementary Figure 2. Mutational profile and PTEN protein expression levels of endometrial cancer cell lines; Supplementary Figure 3. AKT, rpS6 and ERK activation in endometrial cancer cell lines; Supplementary Figure 4. Response of EEC cells to PI3K and RAF/MEK/ERK pathway inhibitors and association with mutation pattern; Supplementary Figure 5. Combination treatment of PI3K and MAPK pathway inhibitors; Supplementary Figure 6. siRNA-mediated KRAS silencing efficiency; Supplementary Figures 7.and 8
Related Article from Test-Firing Ammunition for Spliceosome Inhibition in Cancer
Authors: Dehm Scott M.
Published: April 2023

Related Article from Test-Firing Ammunition for Spliceosome Inhibition in Cancer
Supplementary Figure 1 from HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells
Authors: Duru Nadire , Fan Ming , Candas Demet , Menaa Cheikh , Liu Hsin-Chen , Nantajit Danupon , Wen Yunfei , Xiao Kai , Eldridge Angela , Chromy Brett A. , Li Shiyong , Spitz Douglas R. , Lam Kit S. , Wicha Max S. , Li Jian Jian
Published: April 2023

PDF file - 187K, Enhanced aggressiveness of C6 and HER2 cells
Supplementary Figure S3 from Ligand-Dependent Activation of EGFR in Follicular Dendritic Cells Sarcoma is Sustained by Local Production of Cognate Ligands
Authors: Vermi William , Giurisato Emanuele , Lonardi Silvia , Balzarini Piera , Rossi Elisa , Medicina Daniela , Bosisio Daniela , Sozzani Silvano , Pellegrini Wilma , Doglioni Claudio , Marchetti Antonio , Rossi Giulio , Pileri Stefano , Facchetti Fabio
Published: April 2023

MEK inhibition blocks FDC-S cell growth in a dose-dependent manner.
Supplementary Figures 1-7, Table 1 from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants
Authors: Heuckmann Johannes M. , Balke-Want Hyatt , Malchers Florian , Peifer Martin , Sos Martin L. , Koker Mirjam , Meder Lydia , Lovly Christine M. , Heukamp Lukas C. , Pao William , Küppers Ralf , Thomas Roman K.
Published: April 2023

PDF file - 151K, Supplementary Figure 1 Different EML4-ALK variants elicit similar proliferation rates Supplementary Figure 2 ALK phosphorylation levels after inhibitor treatment Supplementary Figure 3 Schematic representation of EML4-ALK variants 1, 2, 3a and 3b Supplementary Figure 4 TAE684 induced ALK protein degradation Supplementary Figure 5 Protein stability of EML4-ALK variants Supplementary Figure 6 HSP90 inhibitor sensitivity of EML4-ALK variants 2 and 3a Supplementary Figure 7 Bortezomib sensitivity of EML4-ALK variants
Supplementary Table 6 from Next-Generation Sequencing of Translocation Renal Cell Carcinoma Reveals Novel RNA Splicing Partners and Frequent Mutations of Chromatin-Remodeling Genes
Authors: Malouf Gabriel G. , Su Xiaoping , Yao Hui , Gao Jianjun , Xiong Liangwen , He Qiuming , Compérat Eva , Couturier Jérôme , Molinié Vincent , Escudier Bernard , Camparo Philippe , Doss Denaha J. , Thompson Erika J. , Khayat David , Wood Christopher G. , Yu Willie , Teh Bin T. , Weinstein John , Tannir Nizar M.
Published: April 2023

XLSX file - 39K, List of somatic mutations discovered in exome sequencing in MITF/TFE TRCC cases.
Supplementary Tables 1 - 2 from Safety and Pharmacokinetics of Ganitumab (AMG 479) Combined with Sorafenib, Panitumumab, Erlotinib, or Gemcitabine in Patients with Advanced Solid Tumors
Authors: Rosen Lee S. , Puzanov Igor , Friberg Gregory , Chan Emily , Hwang Yuying C. , Deng Hongjie , Gilbert Jill , Mahalingam Devalingam , McCaffery Ian , Michael Shaunita A. , Mita Alain C. , Mita Monica M. , Mulay Marilyn , Shubhakar Poornima , Zhu Min , Sarantopoulos John
Published: April 2023

PDF file, 93KB, Supplemental Table 1. Study Drug Administration; Supplemental Table 2. Summary of Somatic Mutation Status and Tumor PTEN Expression Versus Best Result Change in Tumor Dimensions.
Supplementary Table 3 from PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies
Authors: Chen Benjamin J. , Chapuy Bjoern , Ouyang Jing , Sun Heather H. , Roemer Margaretha G.M. , Xu Mina L. , Yu Hongbo , Fletcher Christopher D.M. , Freeman Gordon J. , Shipp Margaret A. , Rodig Scott J.
Published: April 2023

PDF file - 69K, Supplemental Table 3. Correlative Expression of PD-L1 by Malignant Cells and the Cellular Microenvironment of Examined Tumor Types.
Related Article from The Promise of Patient-Derived Xenografts: The Best Laid Plans of Mice and Men
Authors: Kopetz Scott , Lemos Robert , Powis Garth
Published: April 2023

Related Article from The Promise of Patient-Derived Xenografts: The Best Laid Plans of Mice and Men
Supplementary figure legends from Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF-κB
Authors: Li Xiaoguang , Yang Xinying , Liu Yanling , Gong Nuoxi , Yao Wenbo , Chen Peizhan , Qin Jiangjiang , Jin Huizi , Li Jingquan , Chu Ruiai , Shan Lei , Zhang Ruiwen , Zhang Weidong , Wang Hui
Published: April 2023

Supplementary figure legends
Supplementary figure 3 from Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF-κB
Authors: Li Xiaoguang , Yang Xinying , Liu Yanling , Gong Nuoxi , Yao Wenbo , Chen Peizhan , Qin Jiangjiang , Jin Huizi , Li Jingquan , Chu Ruiai , Shan Lei , Zhang Ruiwen , Zhang Weidong , Wang Hui
Published: April 2023

Inhibition of localized growth and dissemination to multiple organs of NAMALWA cells
Supplementary figure 2 from Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF-κB
Authors: Li Xiaoguang , Yang Xinying , Liu Yanling , Gong Nuoxi , Yao Wenbo , Chen Peizhan , Qin Jiangjiang , Jin Huizi , Li Jingquan , Chu Ruiai , Shan Lei , Zhang Ruiwen , Zhang Weidong , Wang Hui
Published: April 2023

JA causes disruption of the mitochondrial membrane potential in Raji cells.
Supplementary Figures 1 - 13, Tables 1 - 5 from Promoter Hypomethylation of EpCAM-Regulated Bone Morphogenetic Protein Gene Family in Recurrent Endometrial Cancer
Authors: Hsu Ya-Ting , Gu Fei , Huang Yi-Wen , Liu Joseph , Ruan Jianhua , Huang Rui-Lan , Wang Chiou-Miin , Chen Chun-Liang , Jadhav Rohit R. , Lai Hung-Cheng , Mutch David G. , Goodfellow Paul J. , Thompson Ian M. , Kirma Nameer B. , Huang Tim Hui-Ming
Published: April 2023

PDF file - 1049K, Supplementary Figure S1. Summarized sequencing reads and coverage of MBDCap-seq Supplementary Figure S2. Reproducibility test of MBDCap-seq Supplementary Figure S3. Validation of MBDCap-seq by MassARRAY analysis Supplementary Figure S4. Distribution of differentially methylated regions (DMRs) in endometrial tumors relative to normal control Supplementary Figure S5. Network analysis of differential methylation loci by using Steiner-tree analysis Supplementary Figure S6. DNA methylation distribution in early and late stage of the TCGA endometrial cancer cohort Supplementary Figure S7. Relative expression of BMP genes with EGF treatment in the presence or absence of PI3K/AKT and Raf (MAPK) inhibitors in endometrial cancer cells Supplementary Figure S8. Induction of invasion by EGF in AN3CA and HEC1A cell lines Supplementary Figure S9. Knockdown expression of BMP4 and BMP7 in RL95-2 cells Supplementary Figure S10. Relative expression of BMPs and BMPRs in normal endometrial cell and endometrial cancer cell lines Supplementary Figure S11. Microfluidics-based PCR analysis of EMT gene panel in RL95-2 cells with or without EGF treatment Supplementary Figure S12. Knockdown expression of EpCAM by different shRNA sequences in RL95-2 cells Supplementary Figure S13. Proposed model for EpICD mediated regulation of BMP genes by EGF Supplementary Table 1. Characteristics of endometrial cancer patients Supplemental Table 2. Summary of sequencing reads in endometrial tumors an normal controls Supplementary Table 3. Differentially methylated promoter CpG islands in recurrent relative to non-recurrent tumors Supplementary Table 4. List of primer sequences Supplementary Table 5. List of siRNA and shRNA sequences
Data Supplement from GSK-3β–Regulated N-Acetyltransferase 10 Is Involved in Colorectal Cancer Invasion
Authors: Zhang Hong , Hou Wei , Wang Hua-Li , Liu Hai-Jing , Jia Xin-Ying , Zheng Xing-Zheng , Zou Yong-Xin , Li Xin , Hou Lin , McNutt Michael A. , Zhang Bo
Published: April 2023

Supplementary figure legends
Supplementary Figure 3 from Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma
Authors: Khalili Jahan S. , Liu Shujuan , Rodríguez-Cruz Tania G. , Whittington Mayra , Wardell Seth , Liu Chengwen , Zhang Minying , Cooper Zachary A. , Frederick Dennie T. , Li Yufeng , Zhang Min , Joseph Richard W. , Bernatchez Chantale , Ekmekcioglu Suhendan , Grimm Elizabeth , Radvanyi Laszlo G. , Davis Richard E. , Davies Michael A. , Wargo Jennifer A. , Hwu Patrick , Lizée Gregory
Published: April 2023

PDF file, 212K, (A) H&E staining of representative, A375 human xenograft tumor sections excised from NOD/SCID mice. Prior to excision, mice with established tumors were treated for 3 days with either PLX4720 or DMSO vehicle control. Magnification: 4x. (B) RT-PCR analysis of human IL1α, IL1β, IL-8, GRO-α, PD-L1, and PD-L2 transcripts derived from A375 xenografts shown in (A). Data show the average of 3 mice per group, and are representative of 3 separate experiments.
Supplementary figure 1 from A Phase I Trial of Single-Agent Reolysin in Patients with Relapsed Multiple Myeloma
Authors: Sborov Douglas W. , Nuovo Gerard J. , Stiff Andrew , Mace Thomas , Lesinski Gregory B. , Benson Don M. , Efebera Yvonne A. , Rosko Ashley E. , Pichiorri Flavia , Grever Michael R. , Hofmeister Craig C.
Published: April 2023

Supplementary figure 1. The top ten worst adverse events include grade 1 - 3 events. Grade 1 events included decreased neutrophil, white blood cell, lymphocyte, and platelet counts, increased aspartate aminotransferase and alkaline phosphatase, and nausea. Grade 2 events included decreased neutrophil, white blood cell, and platelet counts, anemia, and myalgia. Grade 3 events included decreased neutrophil, white blood cell, and platelet counts, and hypophosphatemia.
Supplementary Figure 1 from Secreted Protein Acidic and Rich in Cysteines-like 1 Suppresses Aggressiveness and Predicts Better Survival in Colorectal Cancers
Authors: Hu Hanguang , Zhang Hang , Ge Weiting , Liu Xiyong , Loera Sofia , Chu Peiguo , Chen Huarong , Peng Jiaping , Zhou Lun , Yu Shujing , Yuan Ying , Zhang Suzhan , Lai Lily , Yen Yun , Zheng Shu
Published: April 2023

PDF file, 65K, Determine the specificity of SPARCL1 antibody.
Supplementary Figure 9 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma
Authors: Chang Hsiu-Hao , Chen Chia-Hua , Chou Chih-Hsing , Liao Yung-Feng , Huang Miao-Juei , Chen Ya-Hsin , Wang Wei-Jen , Huang John , Hung Ji-Shiang , Ho Wan-Ling , Jeng Yung-Ming , Che Mei-Ieng , Lee Hsinyu , Lu Meng-Yao , Yang Yung-Li , Jou Shiann-Tarng , Lin Dong-Tsamn , Lin Kai-Hsin , Hsu Wen-Ming , Huang Min-Chuan
Published: April 2023

PDF file - 53K, Quantitative RT-PCR analysis of mRNA levels of β1-integrin
Supplementary Figure 8 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma
Authors: Chang Hsiu-Hao , Chen Chia-Hua , Chou Chih-Hsing , Liao Yung-Feng , Huang Miao-Juei , Chen Ya-Hsin , Wang Wei-Jen , Huang John , Hung Ji-Shiang , Ho Wan-Ling , Jeng Yung-Ming , Che Mei-Ieng , Lee Hsinyu , Lu Meng-Yao , Yang Yung-Li , Jou Shiann-Tarng , Lin Dong-Tsamn , Lin Kai-Hsin , Hsu Wen-Ming , Huang Min-Chuan
Published: April 2023

PDF file - 154K, Poly-N-acetyllactosamines on both N-glycans and O-glycans of β1-integrin are modified by B4GALT3
Supplementary Figure 1 from β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma
Authors: Chang Hsiu-Hao , Chen Chia-Hua , Chou Chih-Hsing , Liao Yung-Feng , Huang Miao-Juei , Chen Ya-Hsin , Wang Wei-Jen , Huang John , Hung Ji-Shiang , Ho Wan-Ling , Jeng Yung-Ming , Che Mei-Ieng , Lee Hsinyu , Lu Meng-Yao , Yang Yung-Li , Jou Shiann-Tarng , Lin Dong-Tsamn , Lin Kai-Hsin , Hsu Wen-Ming , Huang Min-Chuan
Published: April 2023

PDF file - 45K, Kaplan-Meier survival analysis from Oncogenomics database according to the expression of B4GALT3 in NB patients
Supplementary Table 1 from CADM1 Expression and Stepwise Downregulation of CD7 Are Closely Associated with Clonal Expansion of HTLV-I–Infected Cells in Adult T-cell Leukemia/Lymphoma
Authors: Kobayashi Seiichiro , Nakano Kazumi , Watanabe Eri , Ishigaki Tomohiro , Ohno Nobuhiro , Yuji Koichiro , Oyaizu Naoki , Asanuma Satomi , Yamagishi Makoto , Yamochi Tadanori , Watanabe Nobukazu , Tojo Arinobu , Watanabe Toshiki , Uchimaru Kaoru
Published: April 2023

XLSX file - 47KB, Clinical profile and flow cytometry data of patients with HTLV-1 infection and normal controls.
Data Supplement from Acquired Resistance to Endocrine Treatments Is Associated with Tumor-Specific Molecular Changes in Patient-Derived Luminal Breast Cancer Xenografts
Authors: Cottu Paul , Bièche Ivan , Assayag Franck , El Botty Rania , Chateau-Joubert Sophie , Thuleau Aurélie , Bagarre Thomas , Albaud Benoit , Rapinat Audrey , Gentien David , de la Grange Pierre , Sibut Vonick , Vacher Sophie , Hatem Rana , Servely Jean-Luc , Fontaine Jean-Jacques , Decaudin Didier , Pierga Jean-Yves , Roman-Roman Sergio , Marangoni Elisabetta
Published: April 2023

Supplementary Table S4. Genes differentially expressed between HBCx22 OvaR and HBCx22 and associated gene ontology terms.
Supplementary Figure S3 from CMVpp65 Vaccine Enhances the Antitumor Efficacy of Adoptively Transferred CD19-Redirected CMV-Specific T Cells
Authors: Wang Xiuli , Wong ChingLam W. , Urak Ryan , Mardiros Armen , Budde Lihua E. , Chang Wen-Chung , Thomas Sandra H. , Brown Christine E. , La Rosa Corinna , Diamond Don J. , Jensen Michael C. , Nakamura Ryotaro , Zaia John A. , Forman Stephen J.
Published: April 2023

Supplementary Figure S3. Elevated cytokine levels in the serum of bi-specific T cell treated tumor bearing mice
Supplementary table 1 from Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma
Authors: Böhm Steffen , Montfort Anne , Pearce Oliver M.T. , Topping Joanne , Chakravarty Probir , Everitt Gemma L.A. , Clear Andrew , McDermott Jackie R. , Ennis Darren , Dowe Thomas , Fitzpatrick Amanda , Brockbank Elly C. , Lawrence Alexandra C. , Jeyarajah Arjun , Faruqi Asma Z. , McNeish Iain A. , Singh Naveena , Lockley Michelle , Balkwill Frances R.
Published: April 2023

Total patient cohort
Supplementary figure 1C from ImmunoPET with Anti-Mesothelin Antibody in Patients with Pancreatic and Ovarian Cancer before Anti-Mesothelin Antibody–Drug Conjugate Treatment
Authors: Lamberts Laetitia E. , Menke-van der Houven van Oordt Catharina W. , ter Weele Eva J. , Bensch Frederike , Smeenk Michiel M. , Voortman Johannes , Hoekstra Otto S. , Williams Simon P. , Fine Bernard M. , Maslyar Daniel , de Jong Johan R. , Gietema Jourik A. , Schröder Carolien P. , Bongaerts Alphons H.H. , Lub-de Hooge Marjolijn N. , Verheul Henk M.W. , Sanabria Bohorquez Sandra M. , Glaudemans Andor W.J.M. , de Vries Elisabeth G.E.
Published: April 2023

C. PET uptake in one kidney per patient. On X axis the different PET moments: 2, 4 and 7 days post injection. On the Y axis the SUVmax per patient.
Supplementary figure 1B from ImmunoPET with Anti-Mesothelin Antibody in Patients with Pancreatic and Ovarian Cancer before Anti-Mesothelin Antibody–Drug Conjugate Treatment
Authors: Lamberts Laetitia E. , Menke-van der Houven van Oordt Catharina W. , ter Weele Eva J. , Bensch Frederike , Smeenk Michiel M. , Voortman Johannes , Hoekstra Otto S. , Williams Simon P. , Fine Bernard M. , Maslyar Daniel , de Jong Johan R. , Gietema Jourik A. , Schröder Carolien P. , Bongaerts Alphons H.H. , Lub-de Hooge Marjolijn N. , Verheul Henk M.W. , Sanabria Bohorquez Sandra M. , Glaudemans Andor W.J.M. , de Vries Elisabeth G.E.
Published: April 2023

B. PET uptake in the liver per patient. On X axis the different PET moments: 2, 4 and 7 days post injection. On the Y axis the SUVmax per patient.
Supplementary Tables from Development of Circulating Tumor Cell-Endocrine Therapy Index in Patients with Hormone Receptor–Positive Breast Cancer
Authors: Paoletti Costanza , Muñiz Maria C. , Thomas Dafydd G. , Griffith Kent A. , Kidwell Kelley M. , Tokudome Nahomi , Brown Martha E. , Aung Kimberly , Miller M. Craig , Blossom Dorothy L. , Schott Anne F. , Henry N. Lynn , Rae James M. , Connelly Mark C. , Chianese David A. , Hayes Daniel F.
Published: April 2023

Table S1. Antibodies used for CTC and tissue studies. Table S2. Stage 2 stopping rules for the cumulative number of successfully assayed patients. Table S3. A. CTC-Enumeration Points based on CTC Enumeration B. CTC-Bio-Pointsa Footnotes:aOnly aliquots with CTC {greater than or equal to}5/7.5 ml WB evaluated bLow or negative ER expression is weighed more than BCL-2, HER2, and Ki67 due to its fundamental role in endocrine responsiveness. C. Calculation of CTC-ETI Scores. D. CTC-ETI Categories. Footnote: Abbreviations: CTC= circulating tumor cells; ER = estrogen receptor; ET= Endocrine Therapy; MBC = metastatic breast cancer; ET= endocrine therapy. Table S4. CTC-ETI determination in cultured human breast cancer cell lines spiked into normal human blood and evaluated by the CellSearch® system. Table S5. Examples of low, intermediate, and high CTC-ETI from patient samples. A. LOW CTC-ETI Patient # 5 (Primary Tissue: ER 90% positive, HER2 negative by FISH; Metastatic tissue: ER positive, HER2 negative by FISH)* B. INTERMEDIATE CTC-ETI Patient #4 (Primary Tissue: ER {greater than or equal to}95% positive, HER2 0 by IHC; Metastatic tissue: insufficient tissue to evaluate ER and HER2)* C. HIGH CTC-ETI Patient # 3 (Primary Tissue: ER 60% positive, HER2 1+/2+ by IHC; Metastatic tissue: ER 75% positive; HER2 1+ by IHC)* Footnote: *ER and HER2 as per initial clinical laboratory using the laboratory's criteria for positivity or negativity. Table S6.< CTC-ETI for each patient. Footnote: aAF =Analytical Failure (CTC<5 in 1 of 4 aliquots, while the other 3 aliquots had {greater than or equal to}5 CTC/7.5mL and the average was {greater than or equal to}5 CTC/7.5mL); bTF=Technical Failure (Machine failure in at least one of 4 aliquots). Table S7. Concordance between biomarkers in primary and metastatic tissues and CTC. aKappa score for concordance between CTC and tissue biomarker for respective biomarker.
Supplemental Figure 1 from Impact of Chronic Graft-versus-Host Disease on Late Relapse and Survival on 7,489 Patients after Myeloablative Allogeneic Hematopoietic Cell Transplantation for Leukemia
Authors: Boyiadzis Michael , Arora Mukta , Klein John P. , Hassebroek Anna , Hemmer Michael , Urbano-Ispizua Alvaro , Antin Joseph H. , Bolwell Brian J. , Cahn Jean-Yves Y. , Cairo Mitchell S. , Cutler Corey S. , Flowers Mary E. , Gale Robert P. , Herzig Roger , Isola Luis M. , Jacobsohn David A. , Jagasia Madan H. , Klumpp Thomas R. , Lee Stephanie J. , Petersdorf Effie W. , Santarone Stella , Spellman Stephen R. , Schouten Harry C. , Verdonck Leo F. , Wingard John R. , Weisdorf Daniel J. , Horowitz Mary M. , Pavletic Steven Z.
Published: April 2023

Supplemental Figure 1. Cumulative incidence of cGVHD, relapse and death in patients with AML, ALL, CML, MDS
Supplementary Figure 7 from Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6
Authors: Ziemke Elizabeth K. , Dosch Joseph S. , Maust Joel D. , Shettigar Amrith , Sen Ananda , Welling Theodore H. , Hardiman Karin M. , Sebolt-Leopold Judith S.
Published: April 2023

Cleaved Caspase-3 Expression in CRM 13-180 Tumors. IHC analysis of cleaved caspase-3 expression of CRM 13-180 tumors after treatment with monotherapy or combination therapy with trametinib and palbociclib.
Figure S1 from IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB Activation
Authors: Zhuang Zhuonan , Ju Huai-Qiang , Aguilar Mitzi , Gocho Takashi , Li Hao , Iida Tomonori , Lee Harold , Fan Xiaoqiang , Zhou Haijun , Ling Jianhua , Li Zhongkui , Fu Jie , Wu Min , Li Min , Melisi Davide , Iwakura Yoichiro , Xu Kesen , Fleming Jason B. , Chiao Paul J.
Published: April 2023

Figure S1. A-D, Western blot analysis to determine the phosphorylation of P65 in PATX 43, PATX 50, PATX 53, and PATX 66 cells treated with 5, 10, and 20 μg/mL of rhIL-1RA.
Supplemental Figure S4 from Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo
Authors: Hoffman-Luca C. Gianna , Ziazadeh Daniel , McEachern Donna , Zhao Yujun , Sun Wei , Debussche Laurent , Wang Shaomeng
Published: April 2023

Supplemental Figure S4. Further Characterization of MV4;11 sublines obtained from in vitro treatment with ABT-263 or SAR.
Supplementary Figure 4 from Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell Carcinoma
Authors: Chau Nicole G. , Li Yvonne Y. , Jo Vickie Y. , Rabinowits Guilherme , Lorch Jochen H. , Tishler Roy B. , Margalit Danielle N. , Schoenfeld Jonathan D. , Annino Don J. , Goguen Laura A. , Thomas Tom , Becker Hailey , Haddad Tyler , Krane Jeffrey F. , Lindeman Neal I. , Shapiro Geoffrey I. , Haddad Robert I. , Hammerman Peter S.
Published: April 2023

Presence of PIK3CA Amplification is Associated with Overall Survival Across the Oncopanel Cohort (n=109).
Supplementary Methods from PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity
Authors: Incio Joao , Tam Josh , Rahbari Nuh N. , Suboj Priya , McManus Dan T. , Chin Shan M. , Vardam Trupti D. , Batista Ana , Babykutty Suboj , Jung Keehoon , Khachatryan Anna , Hato Tai , Ligibel Jennifer A. , Krop Ian E. , Puchner Stefan B. , Schlett Christopher L. , Hoffmman Udo , Ancukiewicz Marek , Shibuya Masabumi , Carmeliet Peter , Soares Raquel , Duda Dan G. , Jain Rakesh K. , Fukumura Dai
Published: April 2023

Supplementary Methods
Supplementary Table 4 from Spatiotemporal Heterogeneity Characterizes the Genetic Landscape of Pheochromocytoma and Defines Early Events in Tumorigenesis
Authors: Crona Joakim , Backman Samuel , Maharjan Rajani , Mayrhofer Markus , Stålberg Peter , Isaksson Anders , Hellman Per , Björklund Peyman
Published: April 2023

Supplementary Table 4. A binary distance matrix
Supplementary Fig. 2 from Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Authors: Javeed Naureen , Sagar Gunisha , Dutta Shamit K. , Smyrk Thomas C. , Lau Julie S. , Bhattacharya Santanu , Truty Mark , Petersen Gloria M. , Kaufman Randal J. , Chari Suresh T. , Mukhopadhyay Debabrata
Published: April 2023

Supplementary Fig. 2. PC-derived exosomes from additional PC cell lines and PC patient plasma can decrease insulin secretion. (A-B) PC-Exo isolated from 2 PC patient-derived cell lines decreased insulin secretion in INS-1 cells. (C-D) PC-Exo isolated from 2 different PC patient blood plasma samples can decrease insulin secretion at varying levels. * P<.05; ** P<.001.
Supplementary Figure 1 from The Human Agonistic CD40 Antibody ADC-1013 Eradicates Bladder Tumors and Generates T-cell–Dependent Tumor Immunity
Authors: Mangsbo Sara M. , Broos Sissela , Fletcher Erika , Veitonmäki Niina , Furebring Christina , Dahlén Eva , Norlén Per , Lindstedt Malin , Tötterman Thomas H. , Ellmark Peter
Published: April 2023

Supplementary Figure 1. A) Annexin V positive moDC after ADC-1013 stimulation and B) the effect of cross-linking on percentage of Annexin stained cells (n=6).
Supplementary Tables 1-2 from Galectin-1 Mediates Radiation-Related Lymphopenia and Attenuates NSCLC Radiation Response
Authors: Kuo Peiwen , Bratman Scott V. , Shultz David B. , von Eyben Rie , Chan Cato , Wang Ziwei , Say Carmen , Gupta Aparna , Loo Bill W. , Giaccia Amato J. , Koong Albert C. , Diehn Maximilian , Le Quynh-Thu
Published: April 2023

Supplementary Table 1. Patient characteristics of 20 NSCLC patient receiving SABR. Supplementary Table 2. Patient characteristics of 24 HNSCC patients receiving radiation with cetuximab or cisplatin.
Supplementary Figure 6 from Galectin-1 Mediates Radiation-Related Lymphopenia and Attenuates NSCLC Radiation Response
Authors: Kuo Peiwen , Bratman Scott V. , Shultz David B. , von Eyben Rie , Chan Cato , Wang Ziwei , Say Carmen , Gupta Aparna , Loo Bill W. , Giaccia Amato J. , Koong Albert C. , Diehn Maximilian , Le Quynh-Thu
Published: April 2023

Increases in gal-1 secretion after tumor cell irradiation in vitro.