bluuebunny/crossref_metadata_2025 huggingface dataset:
Online Clinical Pathway for Chronic Kidney Disease Management in Primary Care: A Retrospective Cohort Study
Authors: Donald Maoliosa , Smekal Michelle D. , Elliot Meghan J , McBrien Kerry , Weaver Robert , Manns Braden J. , Tonelli Marcello , Bello Aminu , Strauss Sharon E. , Scott-Douglas Nairne , Jindal Kailash , Hemmelgarn Brenda R.
Published: June 2021

BackgroundClinical pathways aim to improve patient care. We sought to determine whether an online chronic kidney disease (CKD) clinical pathway was associated with improvements in CKD management. MethodsWe conducted a retrospective pre/post population-based cohort study using linked health data from Alberta, Canada. We included adults 18 years or older with mean estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2. The primary outcome was measurement of an outpatient urine albumin creatinine ratio (ACR) in a 28-day period, among people without a test in the prior year. Secondary outcomes included use of guideline-recommended drug therapies (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and statins). Results The study period spanned October 2010 to March 2017. There were 84 independent 28-day periods (53 pre, 31 post pathway implementation) including 345,058 adults. The population was predominantly female (56%) with median age 77 years; most had category 3A CKD (67%) and hypertension (82%). In adjusted segmented regression models, the increase in the rate of change of ACR testing was greatest in Calgary zone (adjusted OR 1.19 per year, 95% CI 1.16-1.21), where dissemination of the pathway was strongest; this increase was more pronounced in those without diabetes (adjusted OR 1.25 per year, 95% CI 1.21–1.29). Small improvements in guideline-concordant medication use were also observed. Conclusions: Following implementation of an online CKD clinical pathway, improvements in ACR testing were evident in regions where the pathway was most actively used, particularly among individuals without diabetes.
Comparative Transcriptomic and Metagenomic Analysis Reveal the Key Factors on the Growth Rate in Red Swamp Crayfish (Procambarus Clarkii)
Authors: Chen Duanduan , Guo Leifeng , Wang Hui
Published: June 2021

Background: Although red swamp crayfish (Procambarus clarkii) is one of the most important species in aquaculture, the factors that influence differences in growth and development between individual siblings are still not fully understood. To address this lack of knowledge, we designed experiments to elucidate factors contributing to individual differences by comparing the hepatopancreatic transcriptome and gut flora structure of individuals with differences in sibling crayfish size under the same rearing conditions and attempted to find links between gut flora and host transcriptome information. Result: In total, 300691028 high-quality reads were obtained that were used to assemble 60637958 unigenes. Comparison of the expression profiles of the hepatopancreas of crayfish of different sizes revealed 497 differentially expressed genes (P<0.05). A total of 32 KEGG signaling pathways were found to be enriched after the KEGG database and GO functional annotation analyses, with the highest number of unigene enrichments related to organismal metabolism. Additionally, we found that proteobacteria, tenericutes, actinobacteria, and bacteroidetes made up a larger portion of the microbiome of larger individuals, suggesting that crayfish microbiota adapts to rapid growth, which may promote accelerated development by regulating the expression level of relevant genes.Conclusions: This work has accumulated data to support the potential impact of structural alterations in gut flora under equivalent feeding conditions in explaining the differential expression of transcriptomic genes among differentially developing individuals of sibling crayfish. These results further elucidate how the intestinal environment affects the rapid development of invertebrate crustaceans and provide a reference for further understanding of the regulatory mechanisms of the host's in vivo environment.
Update on Prevalence of Diagnosed Systemic Lupus Erythematosus (SLE) by Major Health Insurance Types in the US
Authors: Wang Yiting , Hester Laura L , Lofland Jennifer , Rose Shawn , Karyekar Chetan S , Kern David M , Blacketer Margaret , Davis Kourtney , Shields-Tuttle Kimberly
Published: June 2021

ObjectiveTo provide current estimates of the number of patients with prevalent systemic lupus erythematosus (SLE) by major health insurance types in the US and describe patient characteristics. Four large US health insurance claims databases were analyzed to represent different types of insurance coverage, including private insurance, Medicaid, and Medicare Supplemental. ResultsOverall unadjusted SLE prevalence per 100,000 persons in the US ranged from 150.1 (private insurance) to 252.9 (Medicare Supplemental insurance). Extrapolating to the US civilian population in 2016, we estimated roughly 345,000 to 404,000 prevalent SLE patients with private/Medicare insurance, and 99,000 prevalent SLE patients with Medicaid insurance.Comorbidities, including renal failure/dialysis were commonly observed across multiple organ systems in SLE patients (8.4-21.1%). We estimated a larger number of prevalent SLE cases in the US civilian population than previous reports and observed extensive disease burden based on a 1-year cross-sectional analysis.
An Integrated CUT&RUN Quality Control Workflow for Histone Modifications and Transcription Factors
Authors: Boyd Joseph , Rodriguez Princess , Schjerven Hilde , Frietze Seth
Published: June 2021

ObjectiveAmong the different methods to profile the genome-wide patterns of transcription factor binding and histone modifications in cells and tissues, CUT&RUN has emerged as a more efficient approach that allows for a higher signal-to-noise ratio using fewer number of cells compared to ChIP-seq. The results from CUT&RUN and other related sequence enrichment assays requires comprehensive quality control (QC) and comparative analysis of data quality across replicates. While several computational tools currently exist for read mapping and analysis, a systematic reporting of data quality is lacking. Our aims were to 1) compare methods for using frozen versus fresh cells for CUT&RUN and 2) to develop an easy-to-use pipeline for assessing data quality.ResultsWe compared a workflow for CUT&RUN with fresh and frozen samples, and present an R package called ssvQC for quality control and comparison of data quality derived from CUT&RUN and other enrichment-based sequence data. Using ssvQC, we evaluate results from different CUT&RUN protocols for transcription factors and histone modifications from fresh and frozen tissue samples. Overall, this process facilitates evaluation of data quality across datasets and permits inspection of peak calling analysis, replicate analysis of different data types. The package ssvQC is readily available at https://github.com/FrietzeLabUVM/ssvQC.
Studies on the structure, optical, ac conduction mechanism by OLPT model and impedance spectroscopy of La-doped Ba2SnO4 Ruddlesden Popper Oxide
Authors: Kumar Upendra , Maurya Ram Sundar , Cheema Harshpreet , Yadav Vedika , Kumar Aditya , Alvi P. A.
Published: June 2021

The conventional ceramic route has been used to prepare the La-doped Ba2SnO4 samples by heat-treatment at 1000oC and sintered at 1250oC. The phase identification was carried out using XRD and found to be single phase up to 4 atoms %. The solubility of La at Ba-site were further reconfirmed using FTIR and Raman analysis. The AC conductivity spectra of all samples follow universal Johnscher’s power law; however, the thermal dependence of suggest Arrhenius type conduction within the sample. Further, the scaled conductivity and frequency at all temperatures superimposes on a single master curve, indicates the invariance of conduction mechanism. The impedance spectroscopy studies suggest the major contribution of grain in the conduction and relaxation. The present material could be potentially used in semiconductor device, UV-detector, and mixed ionic and electronic conductor (MIECs) by utilizing absorption states and thermo-curves as metastable state.
Malignant Clinical Course of Histologically Benign Ovarian Struma: case report and literature review
Authors: Asaturova Aleksandra , Magnaeva A. , Tregubova A. , Kometova V. , Karamurzin E. , Martynov S. , Lipatenkova Yu. , Adamyan L.
Published: June 2021

BackgroundStruma ovarii is a variant of monodermal teratoma, consisting of morphologically benign, atypical, or frankly malignant thyroid tissue. Morphologic features may or may not correlate with biologic behavior. Albeit this case report is not unique, ovarian tumor developed with peritoneal dissemination and bone metastasis, which is highly unlikely clinical complication. Additionally, we summarized previously cases of struma ovarii with an emphasis on correlation between morphological appearances, clinical course and providing treatment. Case presentationWe present the 38-year-old patient who was hospitalized for ovarian tumor. The diagnostic laparoscopy revealed lesions of peritoneum, sigmoid serosa and omentum and left ovarian mass. We diagnosed left ovarian mature teratoma without struma tissue and metastatic lesions with struma morphology which can be related to her history of left ovarian struma in 2016. Taking into account the metastatic lesions revealed in 2020, the tumor removed in 2016 was assessed as highly differentiated follicular carcinoma arising in struma ovarii. ConclusionsPrediction of biologic behavior of struma ovarii is still to be to diagnostic challenge, therefore multidisciplinary approach including clinical a n d laboratory findings, radiologic details and histopathological features is required. Providing additional data, the present case report contributes to expending the knowledge of these peculiar neoplasms.
Web crawling and mRNA sequencing analyze mechanisms of photobiomodulation
Authors: Wu Hao , Meng Caiyun , Xia Qing , Liu Hailiang , Zhang Fengmin , Song Wuqi
Published: June 2021

Background Photobiomodulation (PBM) is praised as a promising physical therapy, which has many advantages, such as noninvasive, painless. However, the mechanisms are not fully elucidated. Methods Using web crawling, mRNA sequence and bioinformatics analysis to select genes, functional annotation, and mechanisms. The expressions of inflammatory cytokines were measured using RT-qPCR. Results A total of 146 human genes and 57 pathways were identified about PBM. The 630nm LED-stimulated-MH7A cells were sequenced for further analyzing the mechanism of PBM. 2950 differentially expressed genes were identified, and the gene ontology term enrichment analysis and Kyoto encyclopedia of genes and genomes pathway analysis were performed to better understand functions and pathways. The 12 pathways were matched with the KEGG results of PBM and MH7A cells. A protein-protein interaction network was performed among genes in 12 pathways, and 10 outstanding proteins were identified. Importantly, the 9 genes were predicted with potential research value.And we also demonstrated that expression of inflammatory factors (IL-6, IL-1β, IL-8, and MMP-3) was reduced; meanwhile, the expression of anti-inflammatory factor IL-10 was promoted after 630nm LED. In conclusion, using web crawling, bioinformatics analysis, and mRNA sequence, we obtained 9 key genes and 10 important pathways about PBM. Importantly, we demonstrated the anti-inflammatory effect of 630nm LED red light by RT-qPCR.
Semi-Markovian approach to optimizing the time of systematic preventive maintenance and the level of maintenance over a finite horizon
Authors: MBOGNE David Jaures FOTSA , Fonkou Armand , Nzie Wolfgang , Marquez Adolfo Crespo
Published: June 2021

This work is concerned with the problem of optimizing maintenance policies in terms of economical rewards and availability. We consider a system with multiple states in terms of healthy mode (good state, degraded state and failure state) and maintenance action (running state, stopped for maintenance). The level of maintenance (perfect or not) is also taken into account. We propose semi-Markovian model highlighting the eﬀects of dwell times and transitions on economical rewards. We determine an optimal policy conditionally upon the current state according to eight decision parameters related to time intervals between two preventive maintenances and the level of maintenance. We show through a sensitive analysis that decision parameters have nonlocal eﬀects that imply a multiple objective function. Hence, we propose a compromise by optimizing the asymptotic average reward.
Validation of a semiautomatic image analysis software for the quantification of musculoskeletal tissues
Authors: Imani Mahdi , Hassan Ebrahim Bani , Vogrin Sara , Ch'Ng Aaron Samuel Tze Nor , Lane Nancy E. , Cauley Jane A. , Duque Gustavo
Published: June 2021

Background: Accurate quantification of bone, muscle, and their components is still an unmet need in the musculoskeletal field. Current methods to quantify tissue volumes in 3D images are expensive, labor-intensive, and time-consuming; thus, a reliable, valid, and quick application is highly needed.Methods: Tissue Compass is a standalone software for semiautomatic segmentation and automatic quantification of musculoskeletal organs. To validate the software, cross-sectional micro-CT scans images of rat femur (n=19), and CT images of hip and abdomen (n=100) from the Osteoporotic Fractures in Men (MrOS) Study were used to quantify bone, hematopoietic marrow (HBM), and marrow adipose tissue (MAT) using commercial manual software as a comparator. Also, abdominal CT scans (n=100) were used to quantify psoas muscle volumes and intermuscular adipose tissue (IMAT) using the same software. We calculated Pearson's correlation coefficients, individual intra-class correlation coefficients (ICC), and Bland-Altman limits of agreement together with Bland-Altman plots to show the inter- and intra-observer agreement between Tissue Compass and commercially available software.Results: In the animal study, the agreement between Tissue Compass and commercial software was r>0.93 and ICC>0.93 for rat femur measurements. Bland-Altman limits of agreement was -720.89 (-1.5e+04, 13074.00) for MAT, 4421.11 (-1.8e+04, 27149.73) for HBM and -6073.32 (-2.9e+04, 16388.37) for bone. The inter-observer agreement for QCT human study between two observers was r>0.99 and ICC>0.99. Bland-Altman limits of agreement was 0.01 (-0.07, 0.10) for MAT in hip, 0.02 (-0.08, 0.12) for HBM in hip, 0.05 (-0.15, 0.25) for bone in hip, 0.02 (-0.18, 0.22) for MAT in L1, 0.00 (-0.16, 0.16) for HBM in L1, 0.02 (-0.23, 0.27) for bone in L1. The intra-observer agreement for QCT human study between two applications was r>0.997 and ICC>0.99. Bland-Altman limits of agreement was 0.03 (-0.13, 0.20) for MAT in hip, 0.05 (-0.08, 0.18) for HBM in hip, 0.05 (-0.24, 0.34) for bone in hip, -0.02 (-0.34, 0.31) for MAT in L1, -0.14 (-0.44, 0.17) for HBM in L1, -0.29 (-0.62, 0.05) for bone in L1, 0.03 (-0.08, 0.15) for IMAT in psoas, and 0.02 (-0.35, 0.38) for muscle in psoas. Conclusion: Compared to a conventional application, Tissue Compass demonstrated high accuracy and non-inferiority while also facilitating easier analyses. Tissue Compass could become the tool of choice to diagnose tissue loss/gain syndromes in the future by requiring a small number of CT sections to detect tissue volumes and fat infiltration.
Hospital-prepared low-dose atropine eye drops for myopia progression control using atropine sulfate injection diluted in normal saline and lubricants
Authors: Wongwirawat Nuthida , Kuchonthara Nirachorn , Boontanomwong Sorrawit , Pongpirul Krit
Published: June 2021

BackgroundAs commercial low-dose atropine eye-drops for myopia progression control are available in some countries, in-house preparation by diluting the 0.1% atropine eye-drop with sterile water or normal saline has been a common practice. Atropine injection is readily available and could be a more feasible alternative.ObjectiveTo assess the properties of the in-house low-dose atropine eye-drops prepared by diluting the atropine injection in two solvents and tested in two temperature conditions.MethodThe 0.01% atropine eye-drops (15ml) were prepared by diluting atropine sulfate injection with normal saline and lubricant eye-drops and stored at room temperature and in a refrigerator. All samples were daily dropped for 12 weeks to mimic real-life use, one of which was assessed every two weeks for the biological contamination and chemical properties. The active substance was compared with freshly prepared samples at the 12th week.ResultsThe 0.01% atropine eye-drops contains no bacteria, fungi, or particulate matter. The levels of atropine sulfate on all samples were comparable to the freshly prepared samples at the 12th week, regardless of the solvents used or storage conditions.ConclusionThe low-dose atropine eye-drops prepared from readily available atropine sulfate injection at healthcare facilities could be alternative to commercial products
A Hybrid Approach for Predition of Machining Performances of Glass Fiber Reinforced Plastic (Epoxy) Composites
Authors: Raveendran P. , Alagarsamy S. V. , Chanakyan C. , Meignanamoorthy M. , Ravichandran M. , Sakthivelu S.
Published: June 2021

In recent years, Glass Fiber Reinforced Plastic (GFRP) composites are more potential materials for usage in various structural applications in aerospace and automobile industries, owing to its favorable properties, such as light weight, specific strength, high elastic modulus and excellent corrosion resistance. This paper presents a new hybrid approach for multi-objective optimization of machining parameters on GFRP composite using Taguchi coupled grey relational (GR) and desirability function (DF) approach. The end milling of GFRP composite was performed as per Taguchi’s L16 orthogonal array by considering three input parameters: viz. cutting speed (V), feed rate (F) and depth of cut (D), each at four levels. The material removal rate (MRR), surface roughness (SR) and tool wear (TW) were chosen as output responses. The main effect plot was used to determine the optimum level of machining parameters on the multiple responses. Moreover, analysis of variance (ANOVA) were applied to examine the significance of the parameters. Based on the ANOVA results, it was been proved that the depth of cut was the most remarkable parameter, trailed by feed rate and cutting speed, respectively. Finally, the confirmation tests exhibited that the DA approach was employed better in terms of determining the optimum level of machining parameters as compared to GR analysis.
Simulating the behaviour of Glioblastoma Multiforme based on patient MRI during treatments
Authors: Alonzo Flavien , Saad Mazen , Serandour Aurelien
Published: June 2021

Glioblastoma Multiforme is a brain cancer that still show poor prognosis for patients despite the active researches for new treatments. In this work the goal is to model and simulate the evolution of tumour associated angiogenesis and the therapeutic response of the Glioblastoma Multiforme. Multiple phenomena are modelled in order to fit different biological pathways, such as, the cellular cycle, apoptosis, hypoxia or angiogenesis.This results in a nonlinear system with 4 equations and 4 unknowns: the density of tumour cells, the $O_{2}$ concentration, the density of endothelial cells and the vascular endothelial growth factor concentration.This system is solved numerically on a 2D-slice of Magnetic Resonance Imaging, using a nonlinear control volume finite element scheme on a mesh fitting the geometry of the brain and the tumour of a patient.We show that this implicit volume finite element numerical scheme is positive and we give energy estimates on the discrete solution to ensure convergence.The numerical scheme is implicit in time.Numerical simulations of this scheme have been done using the different standard treatments: surgery, chemotherapy and radiotherapy, in order to understand the behaviour of tumour in response to treatments.
Neural networks for computing the continuous nonlinear Fourier spectrum in focusing nonlinear Schrodinger equation: NFT-Net
Authors: Sedov Egor V. , Freire Pedro J. , Seredin Vladimir V. , Kolbasin Vladyslav A. , Kamalian-Kopae Morteza , Chekhovskoy Igor S. , Turitsyn Sergei K. , Prilepsky Jaroslaw E.
Published: June 2021

We combine the nonlinear Fourier transform (NFT) signal processing with machine learning methods for solving the direct spectral problem associated with the nonlinear Schrödinger equation. The latter is one of the core nonlinear science models emerging in a range of applications. Our focus is on the unexplored problem of computing the continuous nonlinear Fourier spectrum associated with decaying profiles, using a specially-structured deep neural network which we coined NFT-Net. The Bayesian optimisation is utilised to find the optimal neural network architecture. The benefits of using the NFT-Net as compared to the conventional numerical NFT methods becomes evident when we deal with noise-corrupted signals, where the neural networks-based processing results in effective noise suppression. This advantage becomes more pronounced when the noise level is sufficiently high, and we train the neural network on the noise-corrupted field profiles. The maximum restoration quality corresponds to the case where the signal-to-noise ratio of the training data coincides with that of the validation signals. Finally, we also demonstrate that the NFT b-coefficient important for optical communication applications can be recovered with high accuracy and denoised by the neural network with the same architecture.
Emergence of Urban Growth Patterns from Human Movements
Authors: Xu Fengli , Li Yong , Jin Depeng , Lu Jianhua , Song Chaoming
Published: June 2021

Cities grow in a bottom-up manner, leading to fractal-like urban morphology characterized by scaling laws. Correlated percolation has succeeded in modeling urban geometries by imposing strong spatial correlations. However, the origin of such correlations remains largely unknown. Very recently, our understanding of human movements has been revolutionized thanks to the increasing availability of large-scale human mobility data. This paper designs a novel computational urban growth model that offers a micro-foundation in human mobility behavior. We compare the proposed model with three empirical datasets, which evidences that strong social couplings and long-memory effect are two fundamental principles responsible for the mystical spatial correlations. The model not only accounts for the empirically observed scaling laws, but also allows us to understand the city evolution dynamically.
Assessing the clinical significance of anti-Cra and anti-M in a chronically transfused sickle cell patient
Authors: Leatherbarro M.B. , Ellisor S.S. , Collins P.A. , Douglas D.K. , Eckrich R.J. , Esty S.S. , Baldwin M.L. , Ness P.M.
Published: June 2021

An alloantibody to a high-incidence antigen, associated with multiple other alloantibodies, made it impossible to supply antigen-negative red blood cells (RBCs) for a chronically transfused sickle cell anemia patient. Anti-Cra, -E, -K, -S, -Fy”, -Fyb, as well as anti-M reactive at 37°C and in the antiglobulin phase of testing, were identified in the patient’s serum. An extensive search of rare donor files at the American Red Cross and at the American Association of Blood Banks (AABB) failed to identify Cr(a —), M–, E–, K –, S –, Fy(a – b –) donors. Various studies were performed to predict the clinical significance of the anti-Cra and anti-M. Results of 51chromium survival studies showed 91.8 percent survival at 10 minutes and 87.2 percent survival at 60 minutes with Cr(a +), M –, E –, K –, S –, Fy(a – b –) red cells, suggesting that immediate destruction of transfused Cr(a +) red cells would be unlikely. However, further analysis revealed diminished long-term survival of the donor’s red cells with only 60.1 percent recovery at six days (T 1/2 = 12 days) and 10.8 percent at 14 days (T 1/2 = 4.5 days). A monocyte-monolayer assay (MMA) indicated that both the anti-Cra (5.9%) and anti-M (18%) would probably be clinically significant (normal value 0 3%). Mass screening continues at several blood centers for Cr(a –),M — ,E-,K—,S—, Fy(a – b –) donors. However, if no suitable donors are found, the results of the 51chromium survival studies and the MMA support the decision to transfuse this patient with Cr(a +), M –, Fy(a–b–),S–,K–,E – red cells, if necessary.
Interacción de las partículas virtuales de antimateria en las partículas reales y la gravedad
Authors: Álvarez Enrique
Published: June 2021

En el presente trabajo proponemos la existencia de subniveles fractales del vacío cuántico, confinados en múltiples dimensiones, que contendrían partículas virtuales de materia y antimateria, las cuales interactúan con las cargas de las partículas reales, afectando también la curvatura espaciotemporal.Palabras clave: Subniveles fractales del vacío cuántico, n – dimensiones, partículas virtuales de antimateria, potencial newtoniano modificado, métrica de Schwarzschild modificada.
Hierofanía y matemática del canal Cumbemayo, Cajamarca, Perú
Authors: Deza Jaime , Castañeda Henry
Published: June 2021

Describe las características geomorfológicas y las matemáticas empleadas en su trazo, así como su asociación con la iconografía que se conduce a lo largo del canal.Fue construido en tres momentos históricos que se diferencia en cada segmento El primer segmento es de 853 metros lineales, totalmente tallado en la roca y emplea la escuadra, el círculo con ángulos de 90 grados y siendo lo más saltante la inclinación constante de 1,5 mm por metro lineal.El centro religioso está asociado al día 17 de diciembre.
DİJİTAL ÇAĞDA DEĞİŞEN EBEVEYNLİK ROLLERİ: TEKNOLOJİ KULLANIMINDA ANNE BABALAR REHBER Mİ ENGEL Mİ OLMALI?
Authors: KURTOĞLU ERDEN Meltem , USLUPEHLİVAN Eda
Published: June 2021

Bir insan yavrusu, en hızlı gelişimini dünyaya geldikten sonraki ilk yıllar içerisinde göstermektedir. Hem fiziksel gelişim hem de bilişsel gelişim açısından yaşamın ilk yılları en önemli yıllardır. Bu süreçte en büyük sorumluluk kuşkusuz ki ebeveynlere düşmektedir. Gelişmekte olan bebeğin beyni çevredeki tüm uyaranlar ile etkileşim halindedir. Beyin gelişiminde en önemli unsur ise bebeğin ebeveynleri ile olan ilişkisi ve yaşadığı ortamdır. Hepimiz yaklaşık yüz milyar nöron ile doğarız. Yapılan çalışmalar kritik sinirsel bağlar olmadan bu nöronların bir işe yaramayacağını göstermektedir. Kritik sinirsel bağların oluşumunda ise bebekle kurulan iletişimin ve etkileşimin önemli olduğu dikkati çekmektedir. İçinde bulunduğumuz dönem dijital ya da bilişim çağı olarak tanımlanabilecek bir dönemdir. Bu dönemde dijital aygıtlar gündelik yaşantımızın ayrılmaz bir parçası olmuştur. Dolayısıyla yenidoğan bebekler, bundan yirmi yıl öncesine göre daha fazla dijital araç gerece maruz kalarak büyümektedirler. Bu bağlamda, bu çalışma “Anne-babalar, bebeklerinin sağlıklı gelişimi için, insan hayatının en kritik dönemi olan 0-36 ay arasında teknoloji kullanımı sürecini nasıl yönetmelidirler?” ve “Bebeklerin bu süreçten en olumlu şekilde etkilenmeleri nasıl sağlanır?” sorularına cevap aramıştır. Buna ek olarak 3-5 yaş arasındaki çocukların teknoloji kullanımı konusunda nelere dikkat edilmesi gerektiği de yazı kapsamında irdelenen bir diğer konudur. Dijital göçmenler olarak tanımlayabileceğimiz anne-babaların, dijital yerli çocukları ile nasıl iletişim kurmaları gerektiği ve bu süreci nasıl yürütmeleri gerektiği ile ilgili öneriler sunularak dijital çağda ebeveynlerin değişen rolleri hakkında bilgi verilmiştir.
DEĞERLER EĞİTİMİ YOLUYLA SURİYELİ SIĞINMACILARIN SOSYAL UYUMU: YARI DENEYSEL BİR ÇALIŞMA
Authors: KAYA Özgür Salih
Published: June 2021

Göçmenlerin göç ettikleri yerde hayata devam edebilmeleri için uyum sağlanması beklenmektedir. Bu nedenle göçmenlere sağlanan maddi desteğin yanı sıra göçmenlerin uyumuna yönelik yapılacak çalışmaların göçmenlerin sosyal uyum sürecini kolaylaştıracaktır. Dolayısıyla bu araştırmada Türkiye’ye göç eden ve Türkiye’de yaşamakta olan 18-30 yaş arasındaki Suriyeli sığınmacıların sosyal uyumunu artırmak amaçlanmıştır. Bu araştırmada nicel araştırma yöntemlerinden yarı-deneysel yöntem kullanılmıştır. Araştırmanın amacına yönelik olarak yarısı Türk yarısı Suriyeli 46 katılımcıdan oluşan gruba bir müdahale programı uygulanmıştır. Katılımcıların belirlenmesi amacıyla ilana çıkılmıştır. Başvurular arasından yapılan görüşmeler sonucu katılımcılar belirlenmiştir. Katılımcıların 23’ü kadın 23’ü erkektir. Katılımcıların yaşları 18-30 arasında değişmekte olup yaş ortalaması 24.62’dir. Katılımcılara öncelikle temel değerler hakkında bilgi verilerek müdahale programı uygulanmıştır. Uygulanan müdahale programı Türk ve Suriyeli katılımcıların empati, benlik saygısı ve pozitif değerler yönünden gelişimine katkı sunmuştur. Deneysel müdahale öncesinde empati, benlik saygısı ve pozitif değerler Türk katılımcılar lehine iken; empati, benlik saygısı ve pozitif değerler müdahale sonrasında anlamlı fark göstermeyip katılımcılar arasındaki anlamlı fark ortadan kalkmıştır. Müdahale programı sosyal uyumu sağlamada farklı etnik gruplar arasında kullanılabilecek bir yöntem olmuştur. Müdahale programı empati, benlik saygısı ve pozitif değerlerin gelişimi yönünde etkili bir uygulama olmuştur.
İZMİR’DE YAŞLILIK HALLERİNİN İNCELENMESİ: YAŞLILARIN FARKLI KURUM DENEYİMLERİNE YÖNELİK FENOMONOLOJİK BİR ARAŞTIRMA
Authors: BARAN Zilan , TEKİNDAL Melike
Published: June 2021

Tüm dünyada sosyo-ekonomik, tıbbi ve teknolojik gelişmeler sonucunda yaşlı nüfusu hızla artmaktadır. Yaşlı nüfusunun gittikçe artması günümüz dünyasının küresel problemlerinden biri haline gelmiştir. Türkiye bu problemi içinde barındıran ülkelerden biridir. Geleneksel aile yapısından modern aile yapısına geçilmesi, kadınların iş hayatına katılması, doğurganlığın azalması ile birlikte aile büyükleri çekirdek aile yaşantısının dışına itilmiştir. Bu da başta barınma olmak üzere tıbbi, ekonomik ve psikososyal sorunları beraberinde getirmektedir. İzmir ili nüfus projeksiyonlarına göre Türkiye’nin en büyük üç ili arasındaki en yüksek yaşlı oranının bulunduğu bir ildir. Çalışmanın amacı; İzmir’de dinlenme evinde yaşayan ve gündüzlü bakımevine giden 60 yaş üstü bireylerin yaşam deneyimlerini görünür kılmaktır. Bu amaç doğrultusunda araştırma nitel araştırma yöntemine sahiptir. Amaçsal örnekleme yöntemine göre İzmir’de yaşayan, belediyeye ait gündüzlü bakımevi ve özel huzurevinde kalan yaşlı bireylerle yapılmıştır. Araştırmaya toplam 19 yaşlı birey katılmış olup bu katılımcıların seçimi bireylerin 60 yaş üzeri ve gönüllü olması kriterleri ile belirlenmiştir. Bireylerle yarı yapılandırılmış derinlemesine görüşme tekniği kullanılarak görüşme sağlanmış ve veriler MAXQDA18 ile tematik içerik analizi yapılarak oluşturulmuştur. Araştırma sonucunda İzmir’de yaşlı olmak odağında “sosyal deneyimleri”, “yalnızlık deneyimleri”, “kurum deneyimleri”, “İzmir deneyimleri”, “önerileri” temaları incelenmiştir.
THE EFFECTS OF THE UNEMPLOYMENT ON THE ATTITUDES TOWARDS SYRIAN REFUGEES: TURKEY CASE
Authors: ADİL Bülent , GÜNER Ümit , KARTAL Cihat
Published: June 2021

International migration movements have very important effects at global, macro and micro levels. These effects come in a wide variety of forms, and they are primarily on socio-economic, political and military areas. Undoubtedly, its negative effects on unemployment are among the most important. The aim of this study is to examine the unemployment perception of citizens in the host country, with reference to the claims that international migration increases unemployment. For this purpose, data from the field study conducted in 2019 on the Syrian refugees in Turkey was used. The data was analysed with the structural equation modelling within the scope of the locals' accepting and rejecting attitudes towards immigrants and a meaningful model has been created. When the regulatory effect of the locals' unemployment status is examined, the effects of unemployed on rejecting immigrants and, the employed on accepting immigrants have been determined.
Influência das crenças e valores no processo de tomada de decisão de gestores de empresas de pequeno porte
Authors: Pereira de Oliveira Brenda , Jones Graciela Dias Coelho
Published: June 2021

O objetivo do estudo é analisar a influência das crenças e valores no processo de tomada de decisão de gestores de pequenas empresas de uma cidade de médio porte localizada no estado de Minas Gerais. Trata-se de uma pesquisa qualitativa que, para o seu desenvolvimento, escolheu por conveniência o setor de panificação. Como instrumento de coleta de dados, é adotada a entrevista semiestruturada com os gestores das empresas. O interacionismo simbólico é a abordagem epistemológica adotada para o estudo, que no seu desenvolvimento são considerados aspectos que influenciam o processo de tomada de decisão. Com base nos resultados do estudo, infere-se que os gestores pesquisados não tomam decisões seguindo apenas aspectos racionais, considerando somente dados numéricos ou avaliando riscos, grande parte da tomada de decisões tende a ser feita com base nas crenças e valores. Como contribuição para o avanço do conhecimento na área, tem-se a identificação do interacionismo simbólico como abordagem epistemológica aliada para estudar e entender o processo decisório de gestores de pequenas empresas.
The Influence of Muhammad Abduh in Indonesia
Authors: Amir Ahmad Nabil , Rahman Tasnim Abdul
Published: June 2021

Muhammad Abduh had a remarkably profound and lasting impact in Indonesia. His reformist ideas had a strong repercussion in the political and social landscape of the region. They were readily adopted by major Islamic movements, notably Muhammadiyah, al-Irshad and Persatuan Islam (Persis). Abduh’s Tafsir al-Manar deeply influenced some momentous works of Qur’anic exegesis, such as Tafsir al-Azhar, Tafsir al-Qur’an al-Karim, Tafsir al-Qur’an al-Madjid (Tafsir al-Nur), Tafsir al-Misbah and Tafsir al-Furqan. His Majallat al-Manar, which was planned and collaborated with Rashid Rida since 1898, highly inspired reform-oriented scholarship evident in journals such as al-Munir, and al-Dhakhirah al-Islamiyah. This study aims to analyze the influence of Abduh’s modernism in Indonesia. It attempts to discover the implication of his principle and philosophical tradition in the religious reform and modern movement in Indonesia. The method of study is based on qualitative approaches, using content analysis method. It was conducted based on library method to investigate the related data from primary and secondary sources. The data was analyzed using descriptive-analytical approaches, by way of inference (istisqa’) and deductive (istinbat) method. The paper concluded that Abduh had profound and extensive influence in the Archipelago, especially his impact on Islamic reform and renewal (islah and tajdid) in Indonesia.
Handling Pandemic in Islamic Literature (Study of The Book "Badzlul Unto Fadhli ath-Thâ'un" by Imam Ibn Hajar al-Asqalani)
Authors: Hariyadi Sugeng , Muflihin Ahmad
Published: June 2021

In the 9th century of hijri., a big scholar in the field of Hadith, Ibn Hajar al-Asqalani has described the guidance of the Shariat in dealing with an pandemic which was packaged in his book "Badzlul Mâ'un fî Fadhli ath-Thâ'un ". This book should be noted through the comparison of the pandemic study between the arguments of the imam with the views of modern scholars, in order to weigh the weight of their respective views. With this comparison, a scientific method of hazanah Islam can be seen in looking at a problematic community that has repeatedly occurred, such as the pandemic COVID-19, as well as connecting the scientific chain and Islamic literature passed down from the Prophet to the next generation, as it is known that the scientific chain known as 'sanad' is part of religion. This research reveals 3 main topics related to pandemic management guidance, namely the validity of syahid status for the dead, the origin of quarantine, and guidance during and after the pandemic.
Protección Radiológica en Radiología Dental
Authors: Wilches Visbal Jorge Homero , Castillo Pedraza Midian Clara , Khoury Helen Jamil
Published: June 2021

El uso de rayos X juega un papel esencial en el diagnóstico y planificación de tratamientos dentales. Los avances tecnológicos de los equipos de rayos X han contribuido al mayor uso de este tipo de radiación en la práctica odontológica. Aunque la exposición a la radiación es baja en estos procedimientos, todavía existe un riesgo que debe reducirse al mínimo necesario a fin de obtener una imagen adecuada para el diagnóstico y a la vez evitar efectos nocivos para el paciente y el personal involucrado. Debido al alto y creciente número de radiografías dentales, el hecho de que niños y adolescentes sean el foco de la mayoría de estas, la subestimación de la cantidad de exámenes radiológicos reportados y la supuesta baja conciencia de estudiantes y profesionales de la odontología sobre los peligros del uso indiscriminado de los rayos X, es necesario adoptar medidas de protección radiológica para mitigar los efectos biológicos radioinducidos. Este artículo tiene como objetivo revisar los principios básicos de la radioprotección que deben considerarse en la práctica dental, con el fin de garantizar el menor daño posible a trabajadores ocupacionalmente expuestos, pacientes y miembros del público.
Assessment of energy efficiency and performance in a two-phase anaerobic process for organic matter removal
Authors: Hurtado Andrea D. P. , Hernández Diana M. , Fuentes Karol L. , Chaparro Tatiana R.
Published: June 2021

Energy efficiency (EE) depends mainly on the lower heating values (LHVs) of hydrogen and methane selected from the thermodynamics tables under ideal conditions. However, for practical applications, the heating value should be calculated by considering some environmental factors under real conditions. Accordingly, this study compared EE using the ideal LHV with the EE using the real LHV in a two-phase anaerobic digestion reactor treating synthetic wastewater. Additionally, the process performance and the stability were studied. The results showed that the EE value calculated using LHVideal was, on average, 35% higher than that evaluated using LHVreal; these differences are relevant to the estimation of real energy and also for practical applications. At the same time, the index buffer intermediate alkalinity/partial alkalinity was shown to be more accurate than the pH value to analyze the stability of the process. With regards to chemical oxygen demand, the removal efficiency in the methanogenic phase decreased drastically when utilizing 100% of the acidogenic phase. Future considerations for the optimization of each phase are highlighted.
Integration of sensors for dam water quality analysis – a prototype
Authors: Rose Lina , Mary X. Anitha , Karthik C.
Published: June 2021

Water consumed is stored in several water bodies in and around us, out of which dams accommodate a major portion of water. The quantity and quality monitoring of water in dams is troublesome due to their large surface area and high depths. Although groundwater resources are the primary water source in India, dams plays a vital role in water distribution and storage network. The Central Water Commission in India has identified more than 5,000 dams of which a major portion is persistently consumed by the rural and urban populations for drinking and irrigation. The water quality of these reservoirs is of serious concern as it would not only affect the socio-economic status of the nation but the aquatic systems as well. Water quality control and management are vital for a delivering clean water supply to the general society. Because of their size, collecting, assessing, and managing a vast volume of water quality data are critical. Water quality data are primarily obtained through manual field sampling; however, real-time sensor monitoring is increasingly being used for more efficient data collection. The literature depicts that the methods involving remote sensing and image processing of water quality analysis consume time, and require sample collection at various depths, analysis of collected samples, and manual interpretations. The objective of this study was to propose a novel cost-effective method to monitor water quality devoid of considerable human intervention. Sensor-based online monitoring aids in assessing the sample with limited technology, at various depths of water in the dam to analyze turbidity which gives the major indication of pure water. The quality analysis of the dam water is suitable if the water is assessed at the distribution end before consumption. Hence, to enhance the water management system, other quality parameters like pH, conductivity, temperature are sensed and monitored in the distribution pipeline. An unstable pH can alter the chemical and microbiological aspects of water, resulting in a variation of other water quality parameters. Temperature variations affect the amount of dissolved oxygen in the water bodies and results in unstable quality parameters. The change in dissolved solvents and the ionic concentration alters the electrical conductivity of the water and the increased concentration of salts also results in turbidity. The data from all the sensors are processed by the microcontroller, transmitted, and displayed in a mobile application comprehensible to the layman.
AS EMENDAS CONSTITUCIONAIS 95/2016, 106/2020 E 109/2021: Inter- relações com o endividamento público e as políticas sociais
Authors: Siqueira Santos Cleidijane , Araújo da Costa João Bosco
Published: June 2021

Este artigo objetiva refletir sobre a aprovação das Emendas Constitucionais 95/2016, 106/2020 e 109/2021 e suas relações com o aumento do endividamento público por meio da adoção de medidas, que beneficiam o mercado financeiro em detrimento do atendimento das necessidades da população. A primeira emenda instituiu um novo regime fiscal por meio do congelamento das despesas primarias em termos reais por vinte anos; as duas últimas foram aprovadas devido ao estado de calamidade pública decretado em 2020 e 2021 em decorrência da pandemia do Coronavírus. A partir da pesquisa qualitativa, bibliográfica e descritiva verifica-se que as medidas adotadas promovem a elevação do endividamento público, mas esse não se traduz em ações que beneficiem a população mais pobre, que arca com os custos do endividamento no presente e também no futuro.
Ergenlerde İletişim Becerileri ve Problem Çözme Becerilerinin İncelenmesi
Authors: Uzak Nihan , Baran Gülen
Published: June 2021

Bu çalışmada, ergenlikte iletişim becerileri ile problem çözme becerilerine etki eden etmenlerin incelenmesi ve iletişim becerileri ile problem çözme becerileri arasındaki ilişkinin belirlenmesi amaçlanmıştır. Çalışmada, nicel araştırma yöntemlerinden “ilişkisel desen” kullanılmıştır. Araştırmanın çalışma grubunu, 2019-2020 yılında Bolu il merkezinde resmi ortaokulların 7. ve 8. sınıflarına devam eden 13-14 yaşlarındaki ergenlerden (n= 323) oluşturmuştur. Çalışmada veri toplama aracı olarak, “İletişim Becerileri Envanteri” ve “İlköğretim Öğrencileri İçin Problem Çözme Becerilerine Yönelik Algı Ölçeği” kullanılmıştır. Ayrıca Kişisel Bilgi Formu vasıtasıyla toplanan bilgiler ile ölçme araçlarından elde elden puanlar SPSS programıyla analiz edilmiştir. Analiz sonucunda ergenlerin iletişim becerileri ve problem çözme becerileri puanlarında öğrenim gördükleri sınıf düzeyine, kardeş sayısına, doğum sırasına, anne-baba öğrenim düzeyine, okul öncesi eğitim alma durumuna ve süresine göre anlamlı bir farklılık tespit edilirken, cinsiyete göre olan anlamlı farklılığın uygulanan ölçeklerin bazı alt boyutlarında olduğu görülmüştür. Ergenlerin problem çözme becerileri ile iletişim becerileri arasındaki ilişki korelasyon analizi ile değerlendirilmiş ve aralarındaki ilişkinin anlamlı olduğu sonucuna ulaşılmıştır. 2018 yılında toplanan Dünya Ekonomik Forumunda 2022 de iş dünyasının arayacağı ilk 10 becerinin 6. Sırasında “kompleks problemleri çözme becerisi” ve 9. Sırasında ise “muhakeme, problem çözme ve hızlı kavrama becerisi” gibi direkt problem çözme becerisiyle ilgili beceriler yer alırken, girişkenlik, duygusal zeka, sosyal nüfus gibi iletişim becerileri ile ilgili beceriler de yine ilk 10 maddenin içinde bulunmaktadır. Erken yıllarda bireylerin iletişim ve problem çözme becerilerinin kazanılmasına yönelik temellerin atıldığı düşünüldüğünde yetişkinlik yıllarına temel oluşturacak bu becerilerin kazanılmasında sunulması gereken destekler öneriler kısmında yer almıştır (World Economic Forum, 2018).
QSCR Analysis of Cytotoxicity of 6-Fluoro-3-(4H-1,2,4-triazol-3-
yl)quinolin-4(1H)-ones on Chinese Hamster Ovary Cell Line: Design
of REPUBLIC1986
Authors: Joon Shikha , Singla Rajeev K. , Shen Bairong , Kamal Mohammad Amjad
Published: June 2021

Background:

6-Fluoro-3-(4H-1,2,4-triazol-3-yl)quinolin-4(1H)-ones are promising
antitumor agents with enormous data on their profound cytotoxic effects on the human
cancer cell lines.

Objectives:

We sought to perform a Quantitative structure cytotoxicity relationship (QSCR)
analysis of a series of previously reported fluoroquinolone analogues using computerassisted
multiple regression analysis and investigate the cytotoxicity-inducing structural parameters
among these congeners.

Methods:

The dataset was segregated into training and test sets of 6-Fluoro-3-(4H-1,2,4-
triazol-3-yl)quinolin-4(1H)-ones by using a random selection method embedded in Vlife
MDS 4.6 software and subjected to QSCR analysis. Next, cross-validation of the generated
QSCR models was performed along with the external test set prediction. Finally, the data
was analyzed and contour plots were developed to deduce the cytotoxicity-inducing structural
parameters among these congeners using Minitab® software.

Results:

The validated QSCR model exhibited a statistically significant predictive value of
92.27 percent. Our QSCR model revealed a direct proportionality between hydrogen counts
and cytotoxicity, and exclusion of sulphur and nitrogen with lesser crowding of cyclopropyl
rings in future potential 6-Fluoro-3-(4H-1,2,4-triazol-3-yl)quinolin-4(1H)-one analogues.
Based on the QSCR model predictions and contour plot analysis, the de novo REPUBLIC1986
molecule provided the best hit with predicted IC50 (μM) of 0.45 against CHO cell
line and is amenable to salt formation crucial for anti-ovarian cancer activity.

Conclusion:

These findings suggest the relevancy of the developed QSCR model in designing
novel, potent, and safer anti-cancer drugs with 6-Fluoro-3-(4H-1,2,4-triazol-3-yl)quinolin-
4(1H)-ones as seed compounds.
Gut Microbiota and Inflammatory Disorders
Authors: Krishna Vamsi , Kumar Naveen , Banerjee Sugato
Published: June 2021

:

The gut has been colonized with bacteria, fungi, viruses, archaea, eukarya. The human and bacterial cells are found in a 1:1 ratio, while the variance in the diversity of gut microbiota may result in dysbiosis. Gut dysbiosis may result in various pathological manifestations. Beneficial gut microbiota may synthesize short-chain fatty acids like acetate, butyrate, propionate. Gram-negative organisms are the primary source of LPS, a potent pro-inflammatory mediator. Both gut microbiota and microbial products may be involved in immunomodulation as well as inflammation. Prebiotics and probiotics are being explored as therapeutic agents against various inflammatory and autoimmune disorders. Here, we discuss the molecular mechanisms involved in gut bacteria mediated modulation of various inflammatory and autoimmune disorders.