bluuebunny/crossref_metadata_2025 huggingface dataset:
Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphoma
Authors: Othman Amal Ibrahim Ahmed , Nasr Merhan , Abdel-Kawi Moustafa
Published: September 2019

Background

The purpose of this study was to compare between contrast-enhanced computer tomography (CE CT) and 18F-FDG PET/CT in the detection of extranodal involvement in lymphoma and to correlate between SUVmax of the extranodal lesion and the hottest LN. One hundred patients with pathologically proven lymphoma underwent whole body 18F-FDG PET/CT and CECT scans. Images were compared regarding the ability of detection of extranodal lymphomatous sites. Kappa agreement was applied to find the degree of agreement between both modalities. Pearson’s correlation was used for correlating SUVmax of the extranodal lesions and hottest LN. The degree of FDG uptake was correlated with histopathological type.

Results

There was a poor agreement between PET/CT and CECT in the detection of extranodal sites (k = 0.32). There was a significant positive moderate correlation between SUVmax of the extranodal lesions and hottest LN (r = 0.45). PET/CT study resulted in up staging of 10% and down staging of 5% of cases.

Conclusion

In lymphoma staging, FDG PET/CT enables more detection of extranodal involved sites that show normal morphology at CECT. It differentiates lymphomatous infiltration from benign causes of increased FDG uptake with subsequent proper disease staging.
Multiple sclerosis and depressive manifestations: can diffusion tensor MR imaging help in the detection of microstructural white matter changes?
Authors: Hassan Talaat A. , Elkholy Shaima Fattouh , Mahmoud Bahaa Eldin , ElSherbiny Mona
Published: September 2019

Background

Multiple sclerosis is one of the commonest causes of neurological disability in middle-aged and young adults. Depression in MS patients can compromise cognitive functions, lead to suicide attempts, impair relationships and reduce compliance with disease-modifying treatments. The aim of this study was to investigate and compare the microstructural changes in the white matter tracts of the limbic system in MS patients with and those without depressive manifestations using a diffusion tensor imaging (DTI) technique.

Methods

This study included 40 patients who were divided into three groups. Group 1 comprised of 20 patients with relapsing-remitting MS with depressive symptoms and group 2 comprised 10 MS patients without symptoms of depression. The third group is a control group that included 10 age-matched healthy individuals. All patients underwent conventional MRI examinations and DTI to compare the fractional anisotropy (FA) values in the white matter tracts of the limbic system.

Results

We compared the DTI findings in MS patients with and those without depressive symptoms. It was found that patients with depression and MS exhibited a significant reduction in the FA values of the cingulum (P < 0.0111 on the right and P < 0.0142 on the left), uncinate fasciculus (P < 0.0001 on the right and P < 0.0076 on the left) and the fornix (P < 0.0001 on both sides). No significant difference was found between the FA values of the anterior thalamic radiations in both groups.

Conclusion

Patients with depression and MS showed more pronounced microstructural damage in the major white matter connections of the limbic pathway, namely, the uncinate fasciculus, cingulum and fornix. These changes can be detected by DTI as decreased FA values in depressed MS patients compared to those in non-depressed patients.
William James and British thought: then and now
Authors: Leary David E.
Published: September 2019

The American psychologist and philosopher William James drew inspiration from British evolutionary theory, neurology, psychiatry, psychology and philosophy. Trained in anatomy, physiology and medicine, he developed a physiological psychology that offered acute analyses of consciousness and of the relations between mind and brain, habit and thought, cognition and emotion and other aspects of psychology. One of his insights, regarding the relation between attention and will, was based upon his own experience of panic anxiety, which was resolved through his reading of several British authors. The story of his psychiatric experience, practical response and later theoretical conclusion offers a potential contribution to contemporary therapeutic practice.
Sentimental Activism as Queer-Feminist Documentary Practice; or, How to Make Love in a Room Full of People
Authors: Heberer Feng-Mei
Published: September 2019

This article explores the possibilities for activist intervention through documentary media at a time when rhetorics of rights and recognition are increasingly appropriated into nationalist state projects, capitalist expansion, and a Northern hemispheric vision of the “good world.” It asks: How do activist media (makers) respond to the appropriation of liberal values? What language—visual, affective, political—do they use to remain morally and aesthetically legible to a wider public and majoritarian decision-makers while insisting on the need for structural transformation? To work through these questions, the article studies the documentary work of queer-feminist migrant labor activism in East Asia. This work offers particularly valuable insight into a strategy summarized here as sentimental activism: the simultaneous repetition and radical decentering of liberal rights discourse and its sensorium of human legibility. While critiques of sentimental affect as manipulative political instrument are numerous, this article probes under what conditions sentimental aesthetics might refuse to repeat and transform the normative paradigms stipulating who deserves rights and recognition in the first place. In focusing on Lesbian Factory (dir. Susan Chen, 2010), a documentary by the Taiwan International Workers’ Association on the collaborative effort of Taiwanese activists and queer Filipina migrant workers to push for better migrant labor rights, this article tracks how the documentary deploys a sentimental lexicon of rights and recognition for transformative ends: to center queer female migrant workers as historical protagonists in struggles for social justice and transformation and as an inspirational source for radical aesthetics.
A Tale of Two Feminists?
Authors: Loshitzky Yosefa
Published: September 2019

One of the most engaging, yet controversial, public intellectuals of the twentieth century, Hannah Arendt continues to be attacked with the same venom and ferocity that followed the publication of Eichmann in Jerusalem: A Report on the Banality of Evil (1963) more than fifty years ago. This article discusses why Arendt remains such a divisive figure and why her intellectual legacy is still so unsettling, particularly for Zionists. The essay examines how these issues are represented, negotiated, and problematized in Margarethe von Trotta’s film Hannah Arendt (Germany/ Luxembourg/France, 2012). It explores how one of the most prominent contemporary feminist filmmakers, whose work celebrates the life and activism of revolutionary women from Rosa Luxemburg to Gudrun Ensslin from the Red Army Faction, transforms the “historical Arendt” into a “cinematic Arendt.” Although not a revolutionary in the tradition of Luxemburg, the German-Jewish political thinker Arendt is an interesting choice for a left-leaning, post-Holocaust German woman director. Yet Arendt presents a paradox for feminists due to the contradictions embedded in her works and public pronouncements. The article examines these contradictions and how Arendt emerges from this film, which attempts to portray a politically engaged intellectual woman, a figure that is almost entirely absent from the film screen.
Not Your Mother’s Melodrama
Authors: McCallum E. L.
Published: September 2019

This essay argues that twenty-first-century melodrama films by female directors rework the core components of classic melodrama form—not only its timing, but also narrative form, agnition, and the underlying fantasy of union. While they retain a focus on objects and setting as bearers of emotion, and on a crisis in intimate relations, the three films by Chantal Akerman, Claire Denis, and Ann Hui considered here reconsider melodrama’s possibilities. They all broach ways of rethinking Oedipal fantasy, moving beyond a story of the fraught emergence of the individual to one focused on a collective problem of how we negotiate a proper proximity to cherished others. All three films turn from what could have been to what the past makes possible now and thus change melodrama from a melancholic genre to a generative one.
Force-generating mechanisms of anaphase in human cells
Authors: Vukušić Kruno , Buđa Renata , Tolić Iva M.
Published: September 2019

What forces drive chromosome segregation remains one of the most challenging questions in cell division. Even though the duration of anaphase is short, it is of utmost importance for genome fidelity that no mistakes are made. Seminal studies in model organisms have revealed different mechanisms operating during chromosome segregation in anaphase, but the translation of these mechanisms to human cells is not straightforward. Recent work has shown that kinetochore fiber depolymerization during anaphase A is largely motor independent, whereas spindle elongation during anaphase B is coupled to sliding of interpolar microtubules in human cells. In this Review, we discuss the current knowledge on the mechanisms of force generation by kinetochore, interpolar and astral microtubules. By combining results from numerous studies, we propose a comprehensive picture of the role of individual force-producing and -regulating proteins. Finally, by linking key concepts of anaphase to most recent data, we summarize the contribution of all proposed mechanisms to chromosome segregation and argue that sliding of interpolar microtubules and depolymerization at the kinetochore are the main drivers of chromosome segregation during early anaphase in human cells.
Determination of pH Dependent Structures of Thymol Blue Revealed by Cooperative Analytical Method of Quantum Chemistry and Multivariate Analysis of Electronic Absorption Spectra
Authors: Shimada Toru , Tochinai Kurumi , Hasegawa Takeshi
Published: September 2019

The pH dependent structure of thymol blue (TB) in solution, a long-standing controversial issue, has been determined by quantum chemistry with an aid of multivariate analysis of electronic absorption spectra. It has been revealed that the TB structure varies from the neutral biprotonated form with open-sulton ring showing red to the monovalent anion of the pure quinoid form showing yellow and then to the quinoid-phenolate form showing blue on raising the pH for a solution.
Analysts’ Beauty and Performance
Authors: Cao Ying , Guan Feng , Li Zengquan , Yang Yong George
Published: September 2019

We study whether sell-side financial analysts’ physical attractiveness is associated with their job performance. We find that attractive analysts make more accurate earnings forecasts than less attractive analysts. Moreover, more attractive analysts make stock recommendations that are more informative in the short run and more profitable in the long run. Additional analyses reveal that attractive analysts attain their better job performance at least partly through their privileged access to information from firm management. For the sources of the beauty effect, we find that more attractive analysts gain more media exposure, have better connections to institutional investors, and receive more internal support from their employers. Additional evidence suggests that analysts’ physical appearance per se at least partly explains our findings. Overall, our study shows that physical attractiveness has a profound impact on the job performance and information access of sell-side financial analysts.

This paper was accepted by Shiva Rajgopal, accounting.
Timing of Auctions of Real Options
Authors: Cong Lin William
Published: September 2019

This paper endogenizes auction timing and initiation in auctions of real options. Because bidders have information rent, a seller faces a “virtual strike price” higher than the actual exercise cost. The seller inefficiently delays the auction to encourage bidder participation and uses the irreversible nature of time to gain partial control over option exercises. The seller’s private benefit at option exercise may restore efficient auction timing, but option exercises are always inefficiently late. When the seller lacks commitment to auction timing, bidders always initiate in equilibrium, resulting in earlier option exercise and higher welfare than auctions proscribing bidder initiation. Overall, auction timing modifies the distribution of the bidder valuations and has important implications for bidding strategies, auction design, and real outcomes.

This paper was accepted by Gustavo Manso, finance.
The role of body image in appearance-related cosmetic procedures
Authors: Woodley Abigail
Published: September 2019

The popularity of cosmetic procedures appears to be on the rise. While this may be the outcome of many factors, including the increasing availability, accessibility and affordability of such procedures, the important and influential role of body image and levels of body dissatisfaction as potentially motivating factors requires attention. This article will discuss the role of body image in appearance-related cosmetic procedures and its implications for patient expectations and outcomes among women.
Intense pulsed light (IPL) and laser hair reduction
Authors: Town Godfrey
Published: September 2019

Demand for long-term hair reduction treatments has increased dramatically around the world in recent years, due to traditional factors, fashion, sport, wellbeing and health requirements. Some of the most popular options include laser and intense pulsed light (IPL) treatments, which are often administered by aesthetic practitioners. This article will discuss the hair growth cycle, as well as treatment options, parameters and outcomes.
NMC issues new guidance on remote prescribing for aesthetic nursing
Authors: Barton Cheryl
Published: September 2019

Earlier this year, the NMC published new guidance regarding remote prescribing. JAN's consultant editor, Cheryl Barton, comments on the implications of this
Research roundup
Authors: Mcgloin Claudia
Published: September 2019

In this regular feature, aesthetic nurse Claudia McGloin presents a brief synopsis of a range of recently published articles on medical aesthetics. Research roundup aims to provide an overview, rather than a detailed summary and critique, of the papers selected. Should you wish to look at any of the papers in more detail, a full reference is provided at the end of each study summary
Practice standard for the management of dermal filler complications
Authors: Davies Emma
Published: September 2019

In recent years, a great deal of attention has been paid to the diagnosis and management of complications arising from the use of dermal fillers. However, alongside the clinical factors, professional considerations must not be neglected, because to do so can lead to often avoidable claims
Changes in employment law mean new rights for workers and new responsibilities for management
Authors: Rayment Andrew
Published: September 2019

As the Good Work Plan is implemented by the Government, 2019 is expected to be a big year for employment laws that will affect businesses
Nutrient Export from Agricultural Watersheds in the Piedmont and Coastal Plain, North Carolina
Authors: Line Dan E. , Osmond Deanna L. , Childres Wesley
Published: September 2019

Nitrogen (N) and phosphorus (P) input and export rates were determined in six rural, predominantly agricultural watersheds located in the Piedmont and Coastal Plain regions of North Carolina. Water quality monitoring was conducted at the outlets for 2.3 to 8.0 years to determine the annual N and P export from each watershed. Total N and P input and export from five of the six watersheds were correlated, with only a no-till cropland watershed differing. The correlation showed that N and P exports increased by about 4.0% and 8.7%, respectively, of applied N and P for the range of applications rates, whereas dissolved N (NOx-N) export increased by 2.8% with increasing N application rates. Therefore, practices that reduce inputs, such as nutrient management, should result in similar percentage reductions in exports. The Small Watershed Nutrient Forecasting Tool (SWIFT) was used to forecast discharge, N, P, and sediment export from each of the six watersheds. For the no-till cropland watershed, the SWIFT-forecasted N and P export rates were more than 2.5 times those measured, while the sediment export rate was 72 times the measured value. Thus, these data showed that the SWIFT forecasts for N, P, and sediment export were poor for the no-till cropland watershed. For the pasture watershed, the SWIFT forecasts for N and sediment export agreed reasonably well with measured export; however, the forecasted P export was much less than measured. For the four mixed land use watersheds, the SWIFT forecasts for discharge, TN, and sediment were mostly greater than measured, and the forecasted TP export was less than measured for three of the four watersheds. Thus, as with many predicstion tools, SWIFT results must be used with caution. Keywords: Nutrient export, Nutrient management practice, Water quality monitoring.
Equilibrium Moisture Content of Hazelnut Husks, Shells, and Kernels
Authors: Bohnhoff David R. , Bohnhoff Rhonda K.
Published: September 2019

Abstract. Hybrid hazelnuts that are predominately a cross between the American hazelnut () and the European hazelnut () are being grown and evaluated as part of an effort to develop a thriving hazelnut industry for the Upper Midwest of the U.S. Along with this plant development effort, researchers are investigating and assessing various harvesting and processing methods and equipment in an effort to create a robust and food-safe production industry. One harvesting alternative is to pick hazelnut clusters off plants before the nuts fully ripen and fall to the ground, an approach that requires greater attention to drying. Whether entire clusters are dried or the nuts are separated from the husks prior to drying is a decision that will be influenced by the drying requirements and potential uses for these hazelnut fractions. To this end, a study was undertaken to establish desorption isotherms for the husks, shells, and kernels of hybrid hazelnuts grown in the Upper Midwest. Clusters were hand-picked from shrubs in Wisconsin and immediately placed in 18 different controlled environments (six different relative humidity levels at three different temperatures). Actual moisture conditioning took place over saturated salt solutions in specially fabricated biomaterial moisture conditioning units. After a six-week period during which the clusters reached equilibrium with their environment via desorption, they were separated into husk, shell, and kernel fractions and returned to their respective conditioning units. After another six weeks in the conditioning units, the moisture content (MC) of each fraction was determined by oven-drying at 103°C for 48 h. Under equilibrium conditions, the kernel MC was found to be only 37% of that for shells, whereas the equilibrium moisture content (EMC) values for husks were on average 14% greater than those for shells. On a dry basis, the average cluster mass was 32.9% husk, 43.9% shell, and 23.2% kernel. Likewise, on a dry basis, the average whole nut mass was 65.5% shell and 34.5% kernel. The desorption data were fit to the Modified Henderson, Modified Chung-Pfost, Modified Halsey, Modified Oswin, and Modified GAB equations. Overall, the best fit to the experimental data was provided by the Modified Chung-Pfost equation with parameters determined using equilibrium relative humidity (ERH) as the dependent variable in regression analyses. For ERH values above 0.70, the temperature-modified form of the GAB equation is recommended for predicting desorption EMC values for hazelnut fractions. Keywords: Desorption, Equilibrium moisture content, Equilibrium relative humidity, Hazelnuts, Kernels, Nuts, Shells, Water activity.
Physical Properties of Upper Midwest U.S.-Grown Hybrid Hazelnuts
Authors: Bohnhoff David R. , Lawson Kenneth Scott , Fischbach Jason A.
Published: September 2019

Abstract. Nuts from F1 hybrid hazelnuts grown in Wisconsin were harvested and dried to eight different moisture contents. Nut dimensions and mass were recorded. Nuts were then subjected to uniaxial compression to determine total deformation required for rupture, rupture force, and rupture energy for each of the three major nut axes. Kernel dimensions, shell thickness, shell mass, and kernel mass of each nut were recorded after rupture. Hybrid hazelnuts and kernels were found to be smaller than European varieties. Nut geometry was found to change with nut size. When a nut is loaded, an initial crack forms along a longitudinal line parallel to the direction of applied load and then rapidly propagates until it has extended along two longitudinal lines (both parallel to the applied load), causing the shell to split into two pieces. Under lateral (Y-axis and Z-axis) loadings, the shell is split into nearly identical halves. Loading along the X-axis required the lowest rupture force, rupture energy, and rupture strain of all loading axes. Rupture force, rupture energy, and stiffness were shown to be highly correlated with moisture content. At lower moisture contents, shells fractured into more pieces. Keywords: Hazelnut, Nut cracking, Nut geometry, Nut rupture force, Shelling, Shell thickness.
The Simulation and Validation of Smoldering in a Burning Cave
Authors: Xu Zhanyang , Liu Wenhe , Wang Tieliang , Bai Yikui , Yu Wei , Zhang Yuqing , Zhang Li
Published: September 2019

Abstract.

In this study, simulations of forward and opposed smoldering in a burning cave were carried out by computational fluid dynamics (CFD) modeling. The fuel in the burning cave was considered a multiphase porous medium with uniform heating. The heat release rates for forward and opposed smoldering in the burning cave were also calculated with an inverse method based on the CFD model. Experiments were conducted to validate the accuracy of the simulation model and the heating performance of the burning cave. The results showed that the model accurately predicted the temperature distributions in the burning cave with an error of 5% to 10% compared to the experimental results. Calculations showed that the heat release rate was 850 W m-3 for forward smoldering and 500 W m-3 for opposed smoldering with an air inlet velocity of 0.1 m s-1. When the air inlet velocity was increased to 0.3 m s-1, the heat release rate increased from 850 to 2,000 W m-3 for forward smoldering and from 500 to 1,000 W m-3 for opposed smoldering. Forward smoldering produced rapid heating in the burning cave but caused uneven temperature distribution on the roof. Conversely, opposed smoldering heated the burning cave at a slower rate, but the temperature distribution on the roof was uniform. Keywords: Burning cave, CFD simulation, Multiphase porous media, Smoldering.
Evaluación de la medicación de riesgo en una residencia de ancianos
Authors: Maldonado Fernández De Gatta Patricia , Fernández De Gatta Garcia María del Mar
Published: September 2019

La identificación de medicamentos de alto riesgo en pacientes crónicos (MARC) polimedicados como los ancianos constituye una estrategia útil para aumentar la seguridad de la farmacoterapia. Con ese fin en el trabajo se aplica  el listado MARC en una población de 103 ancianos ingresados en una residencia vinculada a una  farmacia comunitaria. La identificación se realiza en la dispensación mediante receta electrónica detectándose simultáneamente posibles interacciones  del tratamiento de cada paciente. Posteriormente se  revisan específicamente  los medicamentos más habituales de prescripción inadecuada como son benzodiacepinas, estatinas o IBP.En el estudio se constata que más del 90% de la población tiene prescritos más de un MARC así como que el número de MARC prescritos y de potenciales interacciones se incrementa cuando el paciente pertenece al subgrupo de gran polimedicado (> 10 medicamentos). Sin embargo esas variables no varían en función de la edad o sexo del paciente. Las categorías de medicamentos MARC más prevalentes correspondieron a antiagregantes, benzodiacepinas, AINES y diuréticos. Estos dos últimos grupos justifican gran parte de las interacciones detectadas.La estrategia utilizada en el estudio puede ser útil para introducir los servicios profesionales farmacéuticos en este tipo de entorno clínico.
Biomarcadores de nefrotoxicidad capaces de identificar pacientes oncológicos en riesgo de desarrollar daño renal
Authors: Pérez-Sánchez Laura , Casanova Alfredo Ginés , Morales Ana Isabel
Published: September 2019

Cisplatino y carboplatino son dos fármacos muy usados en el tratamiento de tumores sólidos. Sin embargo, su eficacia está limitada por su nefrotoxicidad. Se ha demostrado que un 25-30% de los pacientes tratados con estos fármacos ha acabado desarrollando un daño renal agudo (DRA). En la actualidad, el diagnóstico del DRA se lleva a cabo mediante el uso de biomarcadores tales como creatinina plasmática y urea, pero resultan poco sensibles y específicos. El objetivo de este trabajo se centra en la búsqueda de biomarcadores urinarios capaces de predecir la aparición de un fallo renal, antes incluso de comenzar dicho tratamiento, siendo capaces de clasificar a los pacientes de acuerdo con su sensibilidad, predecir la evolución de su función renal y llevar a cabo un tratamiento más adaptado a cada paciente.Un estudio clínico fue llevado a cabo con pacientes voluntarios del Servicio de Oncología del Hospital Universitario de Salamanca. Los biomarcadores estudiados fueron proteinuria, N-acetil-?-glucosaminidasa (NAG), Lipocalina asociada a la gelatinada de neutrófilos (NGAL) y albúmina. Para la cuantificación de estos biomarcadores se utilizaron técnicas colorimétricas y la técnica ELISA.Los resultaron mostraron que los niveles de los biomarcadores en el grupo Casos son significativamente superiores a los del grupo Control, tanto en el momento anterior al máximo daño renal, como en el momento basal, lo que nos permitiría saber cuáles son los pacientes que tendrían más probabilidad de sufrir un daño renal antes de iniciar el tratamiento. Dichos marcadores serían un gran avance en el tratamiento quimioterápico, ya que nos permitirían un tratamiento más preventivo y personalizado de cada paciente.
Caracterización in silico de la farmacocinética de clozapina en distintas poblaciones de pacientes.
Authors: García Alejandro , Santos María Dolores
Published: September 2019

La clozapina es un fármaco antipsicótico atípico de estrecho margen terapéutico (0,35 mg/L – 0,60 mg/L) y con riesgo de reacciones adversas poco frecuentes, pero de gran riesgo, por lo que es necesaria su monitorización. Con el avance del diseño de aplicaciones y programas informáticos se pueden realizar simulaciones farmacocinéticas de distintas moléculas para estimar su comportamiento en el cuerpo humano. Este estudio tiene como objetivo realizar diversas simulaciones in silico modificando parámetros de aclaramiento según la edad, el sexo o el hábito tabáquico, comparando los resultados obtenidos con ensayos poblacionales. SymCYP® v16.1 es un software informático que posee librerías de datos fisicoquímicos sobre diversos sustratos y datos poblaciones que, junto a los datos farmacocinéticos obtenidos de la revisión bibliográfica realizada, permiten la simulación de curvas farmacocinéticas y parámetros farmacocinéticos de clozapina en una población determinada. Los resultados obtenidos ponen de manifiesto diferencias significativas en las concentraciones séricas de clozapina en función del sexo y de la edad, siendo necesarios ajustes de dosis para mantener concentraciones dentro de niveles seguros. En conclusión, este trabajo ofrece una nueva visión al desarrollo de nuevas moléculas gracias a la utilización de simulaciones in silico masivas.
Uso de probióticos en oficina de farmacia de Ponferrada(León) en el periodo de febrero a julio del 2018
Authors: Álvarez Núñez Silvia , Escudero Rubio María Mar
Published: September 2019

Existen diversas patologías o efectos secundarios;como los que puede desencadenar el uso de antibióticos; produciendo numerosos desequilibrios en la microbiota.Los probióticos son utilizados para tratar o prevenir un amplio espectro de condiciones patológicas o enfermedadesEl consumo de ellos se realiza através sobretodo de las recomendaciones realizadas por médicos y farmaceuticos, cuando los pacientes acuden a ellos, tras cursar diversas patalogías en las que el probiótico puede ayudarles.Cuando se prescriba el probiótico tanto el farmacéutico como el médico deben comprobar que es el adecuado para la patología que posee el paciente; dependiendo del probiotico poseerá unas cepas concretas que ayudaran a mejorar la patología.
The impact of religious festival on roadside livestock traders in urban and peri-urban areas of Yogyakarta, Indonesia
Authors: Ibrahim Alek , Budisatria I Gede Suparta , Widayanti Rini , Artama Wayan Tunas
Published: September 2019

Background and Aim: Eid al-Adha is one of the most important festivals celebrated by Muslims in Indonesia. Roadside livestock traders open their stalls during the Eid al-Adha period. This study aimed to investigate the characteristics and behaviors of roadside livestock traders in urban and peri-urban areas in Yogyakarta, Indonesia.

Materials and Methods: In-depth interviews with 36 roadside livestock traders were conducted on August 7-23, 2018 in urban (n=20) and peri-urban (n=16) areas of Yogyakarta. The collected data were analyzed by descriptive and statistical analysis using one-way analysis of variance.

Results: The results indicate that the trading activities of roadside livestock traders in urban areas last longer (p<0.05) than in peri-urban areas. No difference was found in the opening day of stalls, the number of buyers, and trends in animal prices set by roadside livestock traders in urban and peri-urban areas. Most traders sell sheep and goats, buy livestock at the animal market, and only open their stalls during Eid al-Adha. Prices are high in this period, and buyers directly visit the stalls. A significant difference exists in the selling price of livestock between Eid al-Adha and ordinary days (non-festival), and most roadside traders benefit from the Eid al-Adha momentum.

Conclusion: Significant similarities exist among roadside livestock traders during the Eid al-Adha period in urban and peri-urban areas of Yogyakarta, Indonesia. Sheep are more desirable than goats and cattle in this period, and Eid al-Adha generates a high profit for roadside livestock traders.
Ovarian reserve and autoimmune thyroid diseases
Authors: Grigoryan Olga R. , Krasnovskaya Natal'ya S. , Mikheev Robert K. , Yarovaya Irina S. , Andreeva Elena N. , Dedov Ivan I.
Published: September 2019

Present literature review provides information about clinical trials that evaluated the association of the carriage of antithyroid antibodies (ATA) and the reduction of the ovarian reserve, as well as the effectiveness of assisted reproductive technologies. The ambiguity and sometimes the opposite of the conclusions of different authors, makes it possible to recommend a balanced attitude to the advisability of screening for ATA in women with a reproductive dysfunction as well as the therapeutic measures proposed in some guidelines based on the results of such examination.
National survey of doctors on hypo-and hypernatremia in the context of real clinical practice
Authors: Pigarova Ekaterina A. , Dzeranova Larisa K. , Zhukov Artem Yu. , Dedov Ivan I.
Published: September 2019

BACKGROUND: The prevalence of dysnatremia varies widely (from 1 to 63%), and depends on comorbidities, the effects of more than 18 hormones and hormone-like substances, which confirms the importance of maintaining blood sodium levels in the tight physiologic range and makes it possible to consider its deviations as an endocrine pathology. Both hypo- and hypernatraemia are associated with a multiple increase in mortality, risk of fractures, and gross balance disturbances. At the same time, the clinical manifestations of dysnatremia are not specific, reflect an osmotically mediated decrease in brain function, which potentially may be missed in clinical practice.
AIMS: to study the specifics of diagnosis, differential diagnosis and treatment of dysnatremia states by specialist doctors using a sociological survey method.
MATERIALS AND METHODS: A cross-sectional sociological uncontrolled study was conducted by questioning doctors about hypo- and hypernatremia using the online questionnaire Questionnaire on hypo-and hypernatremia in clinical practice created on the Google forms platform. The invitation to fill in the questionnaire was sent to the email addresses included in the database of the Russian Association of Endocrinologists. A total of 353 completed questionnaires were received.
RESULTS: The poll demonstrated a low frequency of determining blood sodium levels - less than 38% of specialists prescribe sodium in more than half of the cases, including the cases of diseases associated with dysnatremia, which correlates with less practical experience of doctors. The overwhelming majority of endocrinologists (82%) in their clinical practice encounters deviations of the sodium levels in patients, but only 6% recognize the possession of the competence of managing patients with dysnatremia. The discrepancy between the lower limit of normal range to 135-136 mmol/l was observed in 22% (62/278), the inconsistency of the upper normal limit to 145-146 mmol/l - in 47% (131/278) of laboratories, and in 33% (41/278) laboratories, which are used by doctors, there was a discrepancy along both limits of the reference interval. The presence of a hypertonic solution (3%) of sodium chloride in a hospital was noted only by 38% of respondents.
Conclusions: There is an unphysiological variation in reference intervals for blood sodium concentration in 55% of laboratories, a low frequency of sodium levels evaluation in the blood (in more than half of clinical situations only 38.2% of doctors prescribe the estimation of blood sodium level) and the lack of educational competence in managing patients with syndromes of hypo- and hypernatremia in 94% of endocrinologists.
New ideas about the pathogenesis of osteoarthritis, the role of metabolic disorders
Authors: Alekseeva Lyudmila I.
Published: September 2019

The article highlights the current data on the prevalence and pathogenesis of osteoarthritis (OA), presents a new definition of the disease, research results on the heterogeneity of OA, its relationship with obesity and metabolic syndrome. Obesity is one of the main factors in the development and more rapid progression of OA, and the presence of metabolic syndrome not only increases the risk of developing the disease, but also determines its severity. It is noted that with an increase of the components of the metabolic syndrome, the severity of OA increases. Therefore, hyperuricemia is associated with the presence of osteophytes and the progression of osteoarthritis, hyperglycemia - with the severity of the clinical manifestations and radiological progression. Much attention is given to the treatment of patients with OA and The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) recommendations for the treatment of knee joints OA updated in 2019. In which for the first time a symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are assigned as the basis in the treatment of OA. The data on the effectiveness of some drugs from this group are presented. The glycosaminoglycan-peptide complex, which contains pharmacologically high-quality chondroitin sulfate when administered intramuscularly, has a significant effect on the symptoms, and in case of continued use, slows the progression of OA. The multicenter open-label prospective study of diacerein in patients with knee-joint OA combined with metabolic syndrome showed that during therapy pain syndrome and stiffness are reduced, and functional condition of the joints and quality of life of patients improves quickly and significantly. In addition, the positive effect of the drug on some components of the metabolic syndrome was demonstrated: a significant decrease in body mass index, low density lipoproteins, triglycerides, glucose and uric acid.
Effect of MC4R gene polymorphism on food intake in adolescents with overweight and obesity
Authors: Ievleva Kseniya D. , Bairova Tatyana A. , Sheneman Ekaterina A. , Balzhieva Varvara V. , Ayurova Zhanna G. , Rychkova Lubov V. , Kolesnikova Lubov I.
Published: September 2019

BACKGROUND: The melanocortin 4 receptor gene (MC4R) codes the receptor expressed in the hypothalamus and involved in the regulation of body mass and height. Data on the association of polymorphism MC4R rs17782313 with anthropometric parameters are contradictory.
AIMS: to study the influence of the carrier of polymorphism MC4R rs17782313 on the anthropometric parameters in adolescents of different ethnic groups: caucasians and mongoloids living in the Siberia.
MATERIALS AND METHODS: The study included 179 caucasian adolescents (by the example of russians, average age is 15.07 1.25 years) and 182 mongoloid adolescents (by the example of the buryats, the average age is 14.71 1.28 years), 89 and 92 adolescents were included in groups with overweight and obesity (standard deviation (SDS) BMI 1), in the control groups (SDS BMI from -1 to + 1) also 90 and 90 adolescents were included in the control groups (SDS BMI from -1 to + 1) (russian and buryat, respectively). Anthropometric measurements included height, weight with the calculation of BMI and SDS BMI, WC (waist circumference), HC (hip circumference ). Genotyping was performed by real-time PCR. Statistical analysis of the results of the study was carried out using the software STATISTICA 8.0.
RESULTS: We showed no association of the risky C-allele of polymorphism rs17782313 with overweight and obesity in russian adolescents (22.5% vs 17.9% OR = 1.34 (p 0.05)) and in the buryat (29.8% vs 24.1%, OR = 1.43 (p 0.05)). It was revealed that adolescent carriers of the C-allele in buryat showed higher growth in both groups (control: 162.19 cm vs 157.26 cm (p = 0.019)), the main group: 165.24 cm vs 164.91 cm (p = 0.041)), as well as weight gain in the control group (52.29 kg vs 48.05 kg (p = 0.028)).
CONCLUSIONS: Thus, the study revealed the relationship of MC4R rs17782313 polymorphism with height and weight in adolescents of buryat ethnic group.
Análise da qualidade dos serviços das assessorias em comércio exterior da serra gaúcha: uma aplicação da escala servqual
Authors: Vieira Guilherme Bergmann Borges , Guisolfo Jéssica Ranzolin , Gonçalves Roberto Birch , Da Silva Rafael Mozart
Published: September 2019

O objetivo deste estudo foi avaliar a qualidade dos serviços prestados por empresas de assessoria em comércio exterior atuantes na Serra Gaúcha, no sul do Brasil, identificando os atributos mais importantes e comparando os resultados com um estudo realizado em 2009. A metodologia utilizada foi quantitativa descritiva, operacionalizada mediante a aplicação de um questionário baseado na escala Servqual aos gestores de empresas exportadoras e importadoras que utilizam os serviços de tais assessorias. Os resultados indicam que os atributos confiabilidade, tangibilidade, empatia e custos apresentam significância estatística e explicam quase 94% da avaliação geral dos clientes. Em função disso, recomenda-se que as empresas desenvolvam e monitorem continuamente seu desempenho nesses atributos.
Estudo logístico para instalação de novo cd: abordagem didática de um caso real
Authors: Borella Margareth Rodrigues de Carvalho , Da Silva Guilherme Cardoso
Published: September 2019

O objetivo desse trabalho é fazer um estudo logístico, utilizando técnicas qualitativas e métodos matemáticos, para definição da localização de um novo CD (Centro de Distribuição) e de sua operacionalização, por equipe própria ou de terceiros, de uma empresa distribuidora de componentes pneumáticos, localizada na cidade de Caxias do Sul, Rio Grande do Sul, Brasil. Foram utilizadas, observações in loco no atual CD da empresa para identificar as movimentações de transporte envolvidas, informações da internet sobre mapas rodoviários contendo as distâncias entre as localidades candidatas, dados de volumes transportados, áreas de armazenamento, custos por quilômetro rodado, registros e documentos da empresa. Foram utilizadas técnicas de localização industrial, cálculos de demanda futura e dados de custos logísticos na condução das análises de decisão. A alternativa mais viável envolve a instalação do novo CD na cidade de São Paulo, e as operações internas de movimentação, e externas para o atendimento aos clientes, em relação a esse CD, devem ser conduzidas por equipe terceirizada na figura de operadores logísticos.
Gerenciamento de riscos para a cadeia de suprimentos: uma revisão sistemática de literatura
Authors: Carneiro Matheus Borges , Costa Flávio Henrique de Oliveira , Gilberto Thalisa Maria Jati , Tomas Robson Nogueira
Published: September 2019

Os debates acerca da gestão de riscos para a cadeia de suprimentos têm crescido nos últimos anos, tanto em âmbito internacional quanto nacional, devido ao impacto dos riscos no desempenho das empresas. Assim, este artigo tem por objetivo  apresentar os principais conceitos relacionados ao gerenciamento de riscos em cadeias de suprimentos, os modelos para a gestão destes riscos, bem como estratégias para mitiga-los. Para tanto, foi feita uma revisão sistemática de literatura para identificar as principais pesquisas nesse sentido, nas áreas de gestão de riscos voltada principalmente aos riscos no fornecimento e na demanda, bem como na busca por técnicas e estratégias para mitigação dos riscos. Para trabalhos futuros, sugerem-se a busca por técnicas para medição do desempenho das estratégias de mitigação propostas, assim como uma análise em uma empresa ou cadeia de valor, a fim de se propor um modelo eficaz de gerenciamento dos riscos.
Consumo residencial: uma proposta de modelo de negócio para medidores inteligentes
Authors: Almeida Tatiana Domingues , Fettermann Diego de Castro
Published: September 2019

São verificadas diversas iniciativas, tanto em empreendimentos como na literatura, para o desenvolvimento de produtos inteligentes voltados a aplicações residenciais, principalmente relacionados ao monitoramento e controle de consumo de energia por meio de medidores inteligentes. O uso de medidores inteligentes tem ganhado espaço em diversos países, porém verifica-se que este tipo de aplicação ainda é muito incipiente no Brasil, resultando em altos custos para as concessionárias na realização de coleta de dados de consumo no país. As pesquisas na literatura sobre medidores inteligentes apresentam principalmente foco em aspectos tecnológicos e engenharia de produto, o que resulta em uma lacuna em relação aos aspectos gerenciais e valor ao cliente. Dessa forma, este trabalho tem como objetivo desenvolver uma proposta de modelo de negócio com arranjo flexível voltada ao desenvolvimento e oferta de serviços associado aos medidores inteligentes (água e/ou energia e/ou gás) para uso doméstico. Para tanto, foram utilizadas diversas fontes de evidência a fim de se levantar dados para o desenvolvimento do modelo. Foi possível observar que, de fato, as fontes de evidência da literatura e os casos identificados apresentam foco nos aspectos tecnológicos e estrutura do produto. Os resultados apresentam uma síntese de diversas possibilidades de configuração de modelos de negócio para medidores inteligentes residenciais. A partir disso, este resultado permite estimular o desenvolvimento de negócios para o controle e fomento do consumo consciente de recursos naturais, tais como água, energia e gás, tão estratégicos e críticos para a manutenção do meio ambiente.
Dose Dependent Biological Effects of Idarubicin in HL-60 Cells: Alterations of the Cell-Cycle and Apoptosis
Authors: Mareková Martina , Vávrová Jiřina , Vokurková Doris
Published: September 2019

TP-53 deficient cells of human leukaemia HL-60 die by massive apoptosis after treatment by high (50-100 nmol/l) doses of DNA damaging agent Idarubicin, regardless of the cell-cycle phase, in which they are affected. In contrary, after relatively low dose 10 nmol/l the cells die after cell-cycle arrest in G2phase. The results show, that apoptosis induced by idarubicin could appear independently of the cell-cycle phase and that period in which apoptosis is observed is related to the dose of Idarubicin.
The History of Paediatric Neurosurgery at Medical Faculty of Charles University in Hradec Králové
Authors: Pařízek Jan
Published: September 2019

Article without abstract.
Niełatwa archeologia klifów – przypadek stanowisk w Bagiczu
Authors: Chmiel-Chrzanowska Marta
Published: September 2019

The following paper presents the problem of archaeological sites located on cliffs on the Southern Baltic Sea shore. This article discusses issues related to a necessity of solving the problem of this kind of research, related to methodological, as well as documentation and preservation standards based on preliminary results of the project conducted in Bagicz area (Ustronie Morskie commune). In this region four new structures were noted on a cliff surface. The key to understand the situation of archaeological sites located on a cliff areas is the knowledge of the processes related to their formation and activity. All of them have a huge impact for the state of preservation of the cliff, however they have various intensity level depending on the part of the Baltic Coast.
Kreatywność za drutem kolczastym: archeologia i sztuka okopowa z pierwszowojennego obozu jenieckiego w Czersku (woj. pomorskie)
Authors: Kobiałka Dawid
Published: September 2019

This article discusses the results of archaeological and anthropological research concerning material remains of a prisoner of war camp in Czersk (Pomeranian province, Poland) (Kriegsgefangenenlager Czersk). In the first part, I sketch a broader historical context related to building and functioning of the camp in forests around Czersk between 1914–1919. After that, the role and meaning of  archaeological research on such type of archaeological sites are presented. In the third part, I focus on a very special category of the camp heritage which is called trench art. The last part of this paper is a case study where an assemblage of objects classified as trench art that was found at the camp is described and interpreted. This text aims at highlighting the value of such prisoners and camp’s heritage. Such material culture is a material memory of extraordinary prisoners’ creativity behind barbed wire. It makes one aware of how every piece of trash, rubbish was re-cycled during day-to-day life behind barbed wire.
Czy istnieją nowe możliwości zrozumienia składanek krzemiennych przy wykorzystaniu analizy czasowo-przestrzennej? Propozycja nowej metody
Authors: Migal Witold
Published: September 2019

Refitting of flint materials is in recent times a standard method of dealing with flint materials. Among the archaeologists, however, there is a feeling of insufficiency and disproportion between the time needed for conjoining the blocks and the scientific effects coming out of them. Above all, there is at present no method for comparing different effects with other conjoined blocks. Regardless it comes from one archaeological site or whether are from different ages or territorially distant from each other. The paper presents a proposition of a new method for the analysis of flint refittings. The idea of research is to determine the relationships between the various detached pieces. The results are presented in a graph which we can further analyze and compare with others. The process itself is similar to the simplification of functions invented by Newton and Gauss, which is why the name of the method: refitting calculus.