bluuebunny/crossref_metadata_2025 huggingface dataset:
The Central American Midsummer Drought: Regional Aspects and Large-Scale Forcing*
Authors: Small Richard Justin O. , de Szoeke Simon P. , Xie Shang-Ping
Published: October 2007

The midsummer drought (MSD) is a diminution in rainfall experienced during the middle of the rainy season in southern Mexico and Central America, as well as in the adjacent Caribbean, Gulf of Mexico, and eastern Pacific seas. The aim of this paper is to describe the regional characteristics of the MSD and to propose some possible forcing mechanisms. Satellite and in situ data are used to form a composite of the evolution of a typical MSD, which highlights its coincidence with a low-level anticyclone centered over the Gulf of Mexico and associated easterly flow across Central America. The diurnal cycle of precipitation over the region is reduced in amplitude during midsummer. The MSD is also coincident with heavy precipitation over the Sierra Madre Occidental (part of the North American monsoon). Reanalysis data are used to show that the divergence of the anomalous low-level flow during the MSD is the main factor governing the variations in precipitation. A linear baroclinic model is used to show that the seasonal progression of the Pacific intertropical convergence zone (ITCZ), which moves northward following warm sea surface temperature (SST) during the early summer, and of the Atlantic subtropical high, which moves westward, are the most important remote factors that contribute toward the low-level easterly flow and divergence during the MSD. The circulation associated with the MSD precipitation deficit helps to maintain the deficit by reinforcing the low-level anticyclonic flow over the Gulf of Mexico. Surface heating over land also plays a role: a large thermal low over the northern United States in early summer is accompanied by enhanced subsidence over the North Atlantic. This thermal low is seen to decrease considerably in midsummer, allowing the high pressure anomalies in the Atlantic and Pacific Oceans to extend into the Gulf of Mexico. These anomalies are maintained until late summer, when an increase in rainfall from the surge in Atlantic tropical depressions induces anomalous surface cyclonic flow with westerlies fluxing moisture from the Pacific ITCZ toward Central America.
How Often Will It Rain?
Authors: Sun Ying , Solomon Susan , Dai Aiguo , Portmann Robert W.
Published: October 2007

Daily precipitation data from climate change simulations using the latest generation of coupled climate system models are analyzed for potential future changes in precipitation characteristics. For the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions Scenarios (SRES) B1 (a low projection), A1B (a medium projection), and A2 (a high projection) during the twenty-first century, all the models consistently show a shift toward more intense and extreme precipitation for the globe as a whole and over various regions. For both SRES B1 and A2, most models show decreased daily precipitation frequency and all the models show increased daily precipitation intensity. The multimodel averaged percentage increase in the precipitation intensity (2.0% K−1) is larger than the magnitude of the precipitation frequency decrease (−0.7% K−1). However, the shift in precipitation frequency distribution toward extremes results in large increases in very heavy precipitation events (>50 mm day−1), so that for very heavy precipitation, the percentage increase in frequency is much larger than the increase in intensity (31.2% versus 2.4%). The climate model projected increases in daily precipitation intensity are, however, smaller than that based on simple thermodynamics (∼7% K−1). Multimodel ensemble means show that precipitation amount increases during the twenty-first century over high latitudes, as well as over currently wet regions in low- and midlatitudes more than other regions. This increase mostly results from a combination of increased frequency and intensity. Over the dry regions in the subtropics, the precipitation amount generally declines because of decreases in both frequency and intensity. This indicates that wet regions may get wetter and dry regions may become drier mostly because of a simultaneous increase (decrease) of precipitation frequency and intensity.
Southeast Asian Pressure Surges and Significant Events of Atmospheric Mass Loss from the Northern Hemisphere, and a Case Study Analysis
Authors: Carrera Marco L. , Gyakum John R.
Published: October 2007

A recent study of significant events of atmospheric mass depletion from the Northern Hemisphere (NH) during the extended boreal winter indicated that Southeast Asian pressure surges were an important physical mechanism that acted to channel the atmospheric mass equatorward out of the NH on a rapid time scale. This study builds upon this finding and examines both the direct and indirect roles of Southeast Asian pressure surges for a particular event of dry atmospheric mass depletion from the NH. The focus of this study is on the enhanced interhemispheric interactions and associated Southern Hemisphere (SH) tropical and extratropical responses resulting from the pressure surges.

First, this study examines the conservation of dry atmospheric mass (i.e., the relationship between the dry meridional winds and the area-integrated dry air surface pressure) in the NCEP reanalysis for the 25 significant events of dry atmospheric mass depletion from the NH. Results indicate that the NCEP dry meridional winds are able to qualitatively capture the dry atmospheric mass evacuation from the NH. In a quantitative sense there is very good agreement between the wind and pressure data in the extratropics of both hemispheres. A distinct negative or southward bias in the NCEP vertically and zonally integrated dry meridional winds is apparent between 5° and 17.5°N. This southward bias was not present in the ECMWF Re-Analysis. The source of the southward bias in NCEP appears to result from a weaker analyzed ITCZ.

The particular case of dry atmospheric mass depletion from the NH examined in detail is associated with an intense pressure surge over Southeast Asia. A significant enhancement of convection in the monsoon trough region of northern Australia occurs roughly 4 days after the peak intensity of the Siberian high. A low-level westerly wind burst develops in response to this enhanced zonal pressure gradient caused by the pressure surge as part of the onset of an active phase of the Australian summer monsoon. This study shows that three prominent anticyclonic circulations intensify in the SH extratropics, stretching from the south Indian Ocean to the South Pacific, beneath regions of upper-tropospheric dry atmospheric mass convergence, originating partly from the monsoon convection outflow. These anticyclonic circulations are regional manifestations of the dry atmospheric mass increase in the SH.
Influence of the Arctic Circumpolar Vortex on the Mass Balance of Canadian High Arctic Glaciers
Authors: Gardner Alex S. , Sharp Martin
Published: October 2007

Variability in July mean surface air temperatures from 1963 to 2003 accounted for 62% of the variance in the regional annual glacier mass balance signal for the Canadian High Arctic. A regime shift to more negative regional glacier mass balance occurred between 1986 and 1987, and is linked to a coincident shift from lower to higher mean July air temperatures. Both the interannual changes and the regime shifts in regional glacier mass balance and July air temperatures are related to variations in the position and strength of the July circumpolar vortex. In years when the July vortex is “strong” and its center is located in the Western Hemisphere, positive mass balance anomalies prevail. In contrast, highly negative mass balance anomalies occur when the July circumpolar vortex is either weak or strong without elongation over the Canadian High Arctic, and its center is located in the Eastern Hemisphere. The occurrence of westerly positioned July vortices has decreased by 40% since 1987. The associated shift to a dominantly easterly positioned July vortex was associated with an increased frequency of tropospheric ridging over the Canadian High Arctic, higher surface air temperatures, and more negative regional glacier mass balance.
Decadal Variation of the Southwest U.S. Summer Monsoon Circulation and Rainfall in a Regional Model
Authors: Hu Qi , Feng Song
Published: October 2007

Previous studies have identified several major causes for summer rainfall variations over the southwest United States, for example, land memory (i.e., relationships between antecedent winter season precipitation and snow cover anomalies and subsequent summer rainfall anomalies over the southwest United States; these anomalies are likely most important in the northwest United States, although antecedent anomalies in the southwest United States also may be important in determining summer rainfall variations) and sea surface temperature (SST) anomalies in the North Pacific. Atmospheric responses to these “boundary forces” interact with moisture flows from the Gulf of Mexico and from the Gulf of California to influence the rainfall in the Southwest. The land memory and the SST effects were further found to be “naturally separated,” in the sense that they each played a dominant role influencing the monsoon rainfall variation during different periods of the last century. This separation was also manifested by different dominant low-level moisture transport anomalies in those periods. Several new questions have arisen from these findings: How have the land memory and the SST effects been “separated,” so as to affect the monsoon rainfall variations during different periods, or “regimes”? And, what are the corresponding changes of low-level flows, and hence moisture transports into the southwest United States that help achieve the land memory or the SST effects on the rainfall variations during these different regimes? These questions, and related issues, are addressed using a numerical model of regional climate. The model was used to simulate 14 individual warm seasons (April–October) in each of the postulated regimes. Analyses of the simulation results showed systematic and significant changes in atmospheric circulation anomalies between the two regimes. In the early regime (1961–90), when the land memory effect was strong, the average geopotential height was lower and storm activity was more intense over the central and western United States than in the more recent regime (from 1990 on), indicating reduced eddy energy and momentum exchanges between high and low latitudes in the western United States. The effects of these changes on the monsoon rainfall were achieved by very different low-level flow and moisture transport anomalies. In the earlier regime, low-level flow and moisture transport anomalies in the southwest United States were primarily due to easterlies and southeasterlies into the Southwest for its wet monsoon conditions, with reversed anomalies for dry conditions. In the recent regime, these anomalies changed, with primarily southerlies and southwesterlies from the Gulf of California into the Southwest during its wet monsoon conditions, and reversed flow anomalies for dry conditions. These changes indicate that different physical processes, including those responsible for the planetary-scale atmospheric circulation, led to monsoon rainfall variations during each of these regimes.
Seasonally Stratified Analysis of Simulated ENSO Thermodynamics
Authors: Tozuka Tomoki , Luo Jing-Jia , Masson Sebastien , Yamagata Toshio
Published: October 2007

Using outputs from the SINTEX-F1 coupled GCM, the thermodynamics of ENSO events and its relation with the seasonal cycle are investigated. Simulated El Niño events are first classified into four groups depending on during which season the Niño-3.4 sea surface temperature anomaly (SSTA) index (5°S–5°N, 120°–170°W) reaches its peak. Although the heat content of the tropical Pacific decreases for all four types, the tropical Pacific loses about twice as much during an El Niño that peaks during winter compared with one that peaks during summer. The surface heat flux, the southward heat transport at 15°S, and the Indonesian Throughflow heat transport contribute constructively to this remarkable seasonal difference. It is shown that the Indonesian Throughflow supplies anomalous heat from the Indian Ocean, especially during the summer El Niño–like event. Changes in the basic state provided by the seasonal cycle cause differences in the atmospheric response to the SSTA, which in turn lead to the difference between the surface heat flux and the meridional heat transport anomaly.
A Predictability Measure Applied to Seasonal Predictions of the Arctic Oscillation
Authors: Tang Youmin , Lin Hai , Derome Jacques , Tippett Michael K.
Published: October 2007

In this study, ensemble seasonal predictions of the Arctic Oscillation (AO) were conducted for 51 winters (1948–98) using a simple global atmospheric general circulation model. A means of estimating a priori the predictive skill of the AO ensemble predictions was developed based on the relative entropy (R) of information theory, which is a measure of the difference between the forecast and climatology probability density functions (PDFs). Several important issues related to the AO predictability, such as the dominant precursors of forecast skill and the degree of confidence that can be placed in an individual forecast, were addressed. It was found that R is a useful measure of the confidence that can be placed on dynamical predictions of the AO. When R is large, the prediction is likely to have a high confidence level whereas when R is small, the prediction skill is more variable. A small R is often accompanied by a relatively weak AO index. The value of R is dominated by the predicted ensemble mean. The relationship identified here, between model skills and the R of an ensemble prediction, offers a practical means of estimating the confidence level of a seasonal forecast of the AO using the dynamical model.

Through an analysis of the global sea surface temperature (SST) forcing, it was found that the winter AO-related R is correlated significantly with the amplitude of the SST anomalies over the tropical central Pacific and the North Pacific during the previous October. A large value of R is usually associated with strong SST anomalies in the two regions, whereas a poor prediction with a small R indicates that SST anomalies are likely weak in these two regions and the observed AO anomaly in the specific winter is likely caused by atmospheric internal dynamics.
Human Impact on Direct and Diffuse Solar Radiation during the Industrial Era
Authors: Kvalevåg Maria M. , Myhre Gunnar
Published: October 2007

In this study the direct and diffuse solar radiation changes are estimated, and they contribute to the understanding of the observed global dimming and the more recent global brightening during the industrial era. Using a multistream radiative transfer model, the authors calculate the impact of changes in ozone, NO2, water vapor, CH4, CO2, direct and indirect aerosol effects, contrails, and aviation-induced cirrus on solar irradiances at the surface. The results show that dimming is most pronounced in central Africa, Southeast Asia, Europe, and northeast America. Human activity during the industrial era is calculated and accounts for a decrease in direct solar radiation at the surface of up to 30 W m−2 (30%–40%) and an increase in diffuse solar radiation of up to 20 W m−2. The physical processes that lead to the changes in direct and diffuse solar radiation are found to be remarkably different and the authors explain which mechanisms are responsible for the observed changes.
Enhancement of ENSO Variability by a Weakened Atlantic Thermohaline Circulation in a Coupled GCM
Authors: Dong Buwen , Sutton Rowan T.
Published: October 2007

A coupled ocean–atmosphere general circulation model is used to investigate the modulation of El Niño–Southern Oscillation (ENSO) variability due to a weakened Atlantic thermohaline circulation (THC). The THC weakening is induced by freshwater perturbations in the North Atlantic, and leads to a well-known sea surface temperature dipole and a southward shift of the intertropical convergence zone (ITCZ) in the tropical Atlantic. Through atmospheric teleconnections and local coupled air–sea feedbacks, a meridionally asymmetric mean state change is generated in the eastern equatorial Pacific, corresponding to a weakened annual cycle, and westerly anomalies develop over the central Pacific. The westerly anomalies are associated with anomalous warming of SST, causing an eastward extension of the west Pacific warm pool particularly in August–February, and enhanced precipitation. These and other changes in the mean state lead in turn to an eastward shift of the zonal wind anomalies associated with El Niño events, and a significant increase in ENSO variability.

In response to a 1-Sv (1 Sv ≡ 106 m3 s−1) freshwater input in the North Atlantic, the THC slows down rapidly and it weakens by 86% over years 50–100. The Niño-3 index standard deviation increases by 36% during the first 100-yr simulation relative to the control simulation. Further analysis indicates that the weakened THC not only leads to a stronger ENSO variability, but also leads to a stronger asymmetry between El Niño and La Niña events. This study suggests a role for an atmospheric bridge that rapidly conveys the influence of the Atlantic Ocean to the tropical Pacific and indicates that fluctuations of the THC can mediate not only mean climate globally but also modulate interannual variability. The results may contribute to understanding both the multidecadal variability of ENSO activity during the twentieth century and longer time-scale variability of ENSO, as suggested by some paleoclimate records.
Tests of Monte Carlo Independent Column Approximation in the ECHAM5 Atmospheric GCM
Authors: Räisänen P. , Järvenoja S. , Järvinen H. , Giorgetta M. , Roeckner E. , Jylhä K. , Ruosteenoja K.
Published: October 2007

The Monte Carlo Independent Column Approximation (McICA) method for computing domain-average radiative fluxes allows a flexible treatment of unresolved cloud structure, and it is unbiased with respect to the full ICA, but its flux estimates contain conditional random noise. Here, tests of McICA in the ECHAM5 atmospheric GCM are reported. ECHAM5 provides an interesting test bed for McICA because it carries prognostic variables for the subgrid-scale probability distribution of total water content, which allows us to determine subgrid-scale cloud variability directly from the resolved-scale model variables.

Three experiments with differing levels of radiative noise, each consisting of ten 6-yr runs, are performed to estimate the impact of McICA noise on simulated climate. In an experiment that attempted to deliberately maximize McICA noise, a systematic reduction in low cloud fraction occurred. For a more reasonable implementation of McICA, the impact of noise is very small, although statistically discernible.

In terms of the impacts of noise, McICA appears to be a viable approach for use in ECHAM5. However, to improve the simulation of cloud radiative effects, realistic representation of both unresolved and resolved cloud structures is needed, which remains a challenging problem. Comparison of ECHAM5 data with a global cloud system–resolving model dataset and with International Satellite Cloud Climatology Project data suggested two problems related to unresolved cloud structures. First, ECHAM5 appears to underestimate subgrid-scale cloud variability. This problem seems partly related to the use of the beta distribution scheme for total water content in ECHAM5: in its current form, the scheme is unable to generate highly inhomogeneous clouds (relative standard deviation of condensate amount >1). Second, it appears that in ECHAM5, overcast cloud layers occur too frequently and partially cloudy layers too rarely. This problem is not unique to the beta distribution scheme; in fact, it is more pronounced when using an alternative, relative humidity–based cloud fraction scheme.
Envisioning Nursing in 2050 Through the Eyes of Nurse Theorists: Rosemarie Rizzo Parse and Martha E. Rogers
Authors: Pilkington F. Beryl
Published: October 2007

Rosemarie Rizzo Parse and Rogerian scholar, Violet Malinski, on behalf of Martha E. Rogers, envision how their respective theoretical ideas will be expressed in 2050. Parse introduces several changes highlighting the idea of indivisible cocreation in the ontology of the humanbecoming school of thought and concomitant changes in the wording of its principles. Notions of human freedom and dignity will be extremely important given increasingly mechanized healthcare. Malinski describes Rogerian formulations for practice and research that will continue to facilitate well-being for humankind and the environment. She also addresses challenges and opportunities for an evolving science of unitary human beings.
Practice in 2050: Caring Science and a Synthesis of Views
Authors: Mitchell Gail J.
Published: October 2007

In this column nurses influenced by Watson's human caring theory and Eriksson's theory of caritative caring share their ideas about what nursing theory-guided practice will be like in 2050. Following these contributions about caring theories in 2050, is a synthesis of threads of relatedness across the volume 20 Practice Applications columns—all of which focus on possibilities for nursing theory-guided practice in 2050.
Review of Roy Adaptation Model-Based Qualitative Research
Authors: Perrett Stephanie E.
Published: October 2007

The aim of this paper is to examine the role of qualitative research in the development of the Roy adaptation model. An exploration of the findings from qualitative research using Roy's adaptation model from 1995 to 2005 is compared with the findings and recommendations from a previous review over a 25-year period (1970-1995). The usefulness of qualitative methods in furthering nursing theory is highlighted. Findings from both reviews support the assumptions of the model while generating new information and demonstrating the valuable place of qualitative research in promoting nursing science.
How Much Should We Expect? Family Caregiving of AIDS Patients in Rural Uganda
Authors: Kipp Walter , Tindyebwa Denis , Karamagi Edna , Rubaale Tom
Published: October 2007

The aim of this study was to measure the burden of care for family caregivers of AIDS patients. A cross-sectional exploratory design was used to describe the care experiences of family caregivers of AIDS care recipients. A questionnaire was used to interview 120 family caregivers of AIDS patients from four rural areas in western Uganda. The questions asked were related to 12 domains of family caregiving. Care burden scores of caregivers were calculated. It was found that care burden scores were high in all domains except those regarding relationships within the families and substance abuse. Serious work overload and low health status were reported. The high burden of caregiving puts family caregivers at risk for decreased health status and increased social isolation and depression.
Evaluation of Platelet and Leukocyte Functions in Effort Angina Patients Using High Shear Conditions in Small-Sized Collagen Bead Columns
Authors: Inami Norihito , Nomura Shosaku , Kimura Yutaka , Yamada Kohichi , Nakamori Hisato , Takahashi Nobuyuki , Fukuhara Shirou , Iwasaka Toshiji
Published: October 2007

This study used a small-sized collagen bead column system to investigate platelet functions under high shear stress in 28 patients with effort angina and 15 healthy controls. Soluble P-selectin and soluble L-selectin were also evaluated. Patients underwent stent insertion, followed by treatment with aspirin (100 mg/day) and ticlopidine (200 mg/day). High-shear-dependent platelet function was measured using small-sized collagen beads. The retention rate of platelets from patients with angina was higher than that in healthy controls (10.9% ± 3.9% versus 5.6% ± 1.7%, P < .01). Soluble P-selectin and soluble L-selectin levels of patients with angina significantly increased after passage through the columns. Levels of soluble P-selectin and L-selectin in healthy controls did not exhibit significant changes with passage through the columns. These results suggested that high shear stress caused abnormal activation of leukocytes or adhesive proteins in patients with effort angina, and ticlopidine failed to suppress hyperaggregability of platelets in these patients.
Molecular Analysis of Factor V Leiden, Factor V Hong Kong, Factor II G20210A, Methylenetetrahydrofolate Reductase C677T, and A1298C Mutations Related to Turkish Thrombosis Patients
Authors: Dölek Bilgen , Eraslan Serpil , Eroğlu Sevim , Kesim Belgin Eroglu , Ulutin Turgut , Yalçıner Altan , Laleli Yahya R. , Gözükirmızı Nermin
Published: October 2007

Inherited gene disorders related to the hemostatic system have been documented as risk factors for thrombosis. The roles of factor V Hong Kong (FV Hong Kong), factor V Leiden (FV Leiden), factor II G20210A (FII G20210A), methylenetetrahydrofolate reductase (MTHFR) C677T, and MTHFR A1298C mutations in Turkish patients with thrombosis (270 patients) compared with healthy controls (114 subjects) were evaluated. Polymerase chain reaction—based restriction enzyme analysis was carried out to screen these mutations, and single-strand conformation analysis was established to identify variations using the primers selected for restriction enzyme analysis studies. As a result, a significant relationship was determined among FV Leiden, FII G20210A, and thrombosis. The FV Hong Kong mutation was observed in only 2 patients with pulmonary vein thrombosis who are FV Leiden/FV Hong Kong compound heterozygous for FV gene. MTHFR C677T and A1298C were equally distributed in the patient group compared with the control group. All named mutations were also identified with single-strand conformation analysis, but a new variant/polymorphism during studies was not found. Because some inherited abnormalities are associated with thromboembolic disorders, determining the mutations and gene-to-gene interactions in patients with thrombosis history has a great impact on diagnosis and treatment of these diseases.
Variability in Anticardiolipin Antibody Detection: Role of Nonspecific IgG Binding and Different Microtiter Plates
Authors: Pellegrino Nelly M. , Caccavo Domenico
Published: October 2007

There are many studies that are available on the Internet that attempt to standardize the assay for anticardiolipin antibody evaluation because of the variability of results. The aim of this study was to evaluate simultaneously the role of different microplates and the importance of sample nonspecific binding in determining different results in anticardiolipin antibody detection. Sera from 8 patients with raised levels of IgG anticardiolipin antibodies and 10 control sera were assayed by enzyme-linked immunosorbent assay in the presence (specific binding) or in the absence of cardiolipin (sample blank) with four different microplates, that is, NUNC PolySorp, FALCON ProBIND, Greiner 655061 (high binding), and Greiner 655001 (medium binding). Results were expressed as optical densities or net-optical densities (following sample blank subtraction) as well as international IgG anticardiolipin units (GPL) or net-GPL. A wide interplate variability of optical densities was found. When results were expressed as GPL, significant differences were only found between Greiner 655061, FALCON ProBIND, and NUNC PolySorp ( P < .05 and P < .001, respectively) whereas differences were not statistically significant if interplate variability was analyzed as net-GPL. Results expressed as categorical variables (ie, positive/negative, according to a GPL cut-off and net-GPL cut-off, obtained with sera from 100 apparently healthy blood donors) showed a good or excellent Cohen's κ coefficient of concordance among plates when positivity was evaluated on net-GPL. Our data strongly suggest that quantification and subtraction of sample blank may improve both interlaboratory agreement and reliability of anticardiolipin assay and minimize false-positive results.
Singlet Oxygen Enhances Intrinsic Thrombolysis: The Intrinsic Oxidative Clot Lysis Assay (INOXCLA)
Authors: Stief Thomas W.
Published: October 2007

Granulocytes are important cells of inflammation and cellular thrombolysis. They produce urokinase (u-PA) and chloramines. In this study, u-PA/chloramine—mediated fibrinolysis is imitated in a microtiter-plate. Seventy-five microliters plasma are incubated with 50 μL 50% Pathromtin SL, 6% BSA, and 38 mM CaCl2 for 30 minutes (37°C). Then, 50 μL 10 mM chloramine-T in PBS are added. After 30 minutes (37°C), 50 μL 0, 100, or 10 IU/mL u-PA in 6% BSA-PBS are added and the turbidity is determined at 405 nm after 0, 3, or 16 hours. Clot lysis was increased more than tenfold by 0.5 to 1 μmoles chloramine (ED50 after 3h = about 0.25 μmoles = 2mM final concentration). The normal range for the present intrinsic oxidative clot lysis assay (INOXCLA) is 100% ± 25% (MV ± SD; 100 relative % of norm; the normal lysis being 60 absolute %; CVs < 10%). Fifty percent lysis of adherent microclots occurred after 0.75 hours, 2 hours, 14 hours, 13 days, or 17 days when using 1000, 100, 10, 1, or 0 IU/mL u-PA reagent. If the u-PA activity is quenched by PAI-2, no clot lysis appears. Chloramines are important physiologic generators of nonradical excited singlet oxygen and enhance u-PA—mediated lysis of plasma clots. Based on the u-PA/chloramines coaction, a new global fibrinolysis assay has been derived.
Youth Violence in Context
Authors: Peterson Dana , Esbensen Finn-Aage , Taylor Terrance J. , Freng Adrienne
Published: October 2007

Youth violence garners considerable attention in the media as well as in public policy debates. In spite of this interest and attention to youth violence, stereotypes fueled by misperceptions about the epidemiology of youth violence often drive these discussions. Urban minority youth, especially males, are typically presented as the “dark stranger” responsible for much of this violence. Criminal justice and juvenile justice data tend to reinforce this perspective. In this article, the authors call into question the extent to which violent juvenile offending can be characterized as an urban minority male problem. A multisite sample of middle school students was used to examine the distribution of violent offending by sex, race/ethnicity, and community of residence.
Disputatiousness, Aggressiveness, and Victimization Among Street Youths
Authors: Baron Stephen W. , Forde David R. , Kennedy Leslie W.
Published: October 2007

Utilizing a sample of 125 male street youths, the article examines how homelessness and deviant lifestyles increase exposure to conflict and how the interactional dynamics of these disputes lead to violence and victimization. Results indicate that street youths' deviant peers leave them more likely to perceive harm and to use force to settle disputes. Perceptions of harm and the willingness to use force to settle a dispute are also associated with drug use, the gender of the harmdoer, and the intensity of the conflict. In turn, drug use, deviant peers, and the willingness to use force are associated with increases in violence as an offender; and this violence, along with alcohol use, is associated with victimization. Findings are discussed in terms of how lifestyle and dispute context and evolution are important to understanding street youths' conflict and victimization.
Characterization of a tropical soil and a waste from kaolin mining and their suitability as heterogeneous catalysts for Fenton and Fenton-like reactions
Authors: Pereira M. C. , Tavares C. M. , Fabris J. D. , Lago R. M. , Murad E. , Criscuolo P. S.
Published: October 2007

Alternative Fenton and Fenton-like systems based on natural Fe oxides are described. The collected materials were modified through controlled reduction with H2 and were characterized by chemical analysis, X-ray diffraction, saturation magnetization measurements, and Mössbauer spectroscopy at 298 and 110 K. The catalytic activities of these original and modified materials were tested by studying the decomposition of H2O2 and the discolouration of methylene blue. Iron oxides present in the samples were mainly hematite and subordinate goethite which, after controlled reduction, were converted to metallic iron and magnetite. The mixture of Fe0 and magnetite in one of these materials was significantly more efficient at H2O2 decomposition and the discolouration of methylene blue than the original Fe3+ oxides. These results suggest that Fe2+ is essential to produce an active Fenton system.
Filtration and standardized properties of Jebel Om El Khecheb clay (Tunisia) and Wyoming bentonite
Authors: Laribi S. , Fleureau J.-M. , Kbir-Ariguib N.
Published: October 2007

The rheological and filtration properties of a Tunisian clay are presented and compared with those of Wyoming bentonite. The study was part of an evauation of Tunisian mining resources in general, and of the bentonitic deposits in particular. Qualitatively, the two clays exhibit the same rheological and filtration behaviour but quantitatively the properties of purified Wyoming bentonite are distinctly better at the same concentration. The difference can be related to the mineralogical structure and the presence of 13% illite in the Tunisian clay. Standard tests show that the rheological behaviour of the purified Tunisian clay is close to that of the raw Wyoming bentonite and conform to the American Petroluem Institute (A.P.I.) standards for medium-depth drilling formulations.
Polycation adsorption on montmorillonite: pH and T as decisive factors for the kinetics and mode of chitosan adsorption
Authors: An J.-H. , Dultz S.
Published: October 2007

Adsorption of the polycation chitosan on montmorillonite was studied at different pH values from 4.5 to 6.5 and at temperatures of 25, 50 and 75ºC. The amount of chitosan adsorbed increased with temperature, indicating that temperature is a decisive factor. At pH 5.0 and 25ºC the amount adsorbed was 1.18 molc kg–1, whereas it was 1.5 times higher (1.79 molc kg–1) at 75ºC. The uptake of chitosan increased significantly at higher pH. This can be attributed to the decrease in the degree of protonation. Surface charge and X-ray diffraction measurements indicate that most of the chitosan is adsorbed in the interlayer, where mono- and bilayer structures are formed.

The kinetics of chitosan adsorption also depend on temperature and pH. At ⩾ 50ºC, the adsorption mechanism of chitosan on montmorillonite is closest to the intraparticle diffusion model, whereas at lower temperature (25ºC) the adsorption process is closer to the pseudo-second order model. The pH of the solution affects the protonation degree of chitosan and the mode of adsorption on montmorillonite, but not the adsorption rate.

For chitosan-montmorillonite prepared at pH 5.0 and 75ºC, the effective anion exchange capacity (AEC) was found to be 80% (0.36 molc kg–1) of the calculated value. The relatively large AEC and the location of most of the anion exchange sites in the interlayer make chitosan-montmorillonite an interesting prospect as an adsorbent for water-purification procedures.
Clay mineral reactions in an active geothermal area (Mt. Amiata, southern Tuscany, Italy)
Authors: Battaglia S. , Gherardi F. , Gianelli G. , Leoni L. , Origlia F.
Published: October 2007

This study characterizes the effects of fluid migration into a predominantly shale cover which seals the active geothermal system of Mt. Amiata (Tuscany, Italy). During Alpine orogenesis the shale unit was affected by regional metamorphism at the limit of the diagenesis-anchizone. Subsequently, the phyllosilicate clay minerals of the shales underwent significant alteration at diagenetic temperatures (175±25ºC as determined by the geochemical model) by the pervasive circulation of fluids activated by the geothermal field. The overall mineralogical assemblages indicate that the main transformations consisted mostly of destabilization of illite and formation of kaolinite together with large amounts of I-S mixed layers, with higher smectite content and decreased Reichweite I-S ordering (from R3 to R1) with respect to the original, unaltered phases. Application of computer modelling indicates that the circulation of CO2-rich geothermal fluids into the shale unit was responsible for the observed phyllosilicate clay mineral transformations.
Effect of slope aspect on transformation of clay minerals in Alpine soils
Authors: Egli M. , Mirabella A. , Sartori G. , Giaccai D. , Zanelli R. , Plötze M.
Published: October 2007

Two soil profile sequences on paragneiss debris in the Val di Rabbi (Northern Italy) along an altitude gradient ranging from 1200 to 2400 m a.s.l. were studied to evaluate the effect of aspect on the weathering of clay minerals. All the soils had a coarse structure, a sandy texture and a low pH. Greater weathering intensities of clay-sized phyllosilicates (greater content of smectites) were observed in soils on the north-facing slope. On the south-facing slope, smectite was found only in the surface horizon of the soil profile at the highest altitude. Hot citrate treatment of north-facing soils revealed the presence of low-charged 2:1 clay minerals, the expansion of which was hindered in the untreated state by interlayered polymers. However, the hot citrate treatment encountered some problems with the samples of the south-facing soils: as confirmed by Fourier transform infrared spectroscopy, the hot citrate treatment was unable to remove all interlayer Al polymers. The 2:1 phyllosilicates were not expanded by ethylene glycol solvation in several samples, although thermogravimetric analyses indicated the presence of clay minerals with interlayer H2O. At the same time, the collapse of clay minerals to 1.0 nm following K-saturation was evident. Theoretically, this should indicate that 2:1 phyllosilicates had no evident substitution of trioctahedral cations (Mg2+, Fe2+) by dioctahedral cations (Al3+ and Fe3+). X-ray diffraction analysis of the d060 region and determination of the layer charge of clay minerals by the long-chain (C18) alkylammonium ion, however, did not confirm this. A transformation from trioctahedral to dioctahedral species was observed and low-charge clay minerals (ξ ~0.30) were identified in the surface horizons of the south-facing sites. In the south-facing soils, the podzolization process was less pronounced because of a lower water flux through the soil and probably less complexing organic molecules that would remove the interlayer polymers. Besides the eluviation process, clay minerals underwent a process of ionic substitutions in the octahedral sheet that led to the reduction of the layer charge. This process was more obvious in the north-facing sites.
Immunogenicity of umbilical cord tissue–derived cells
Authors: Cho Patricia S. , Messina Darin J. , Hirsh Erica L. , Chi Nina , Goldman Stephanie N. , Lo Diana P. , Harris Ian R. , Popma Sicco H. , Sachs David H. , Huang Christene A.
Published: October 2007

Umbilical cord tissue provides a unique source of cells with potential for tissue repair. Umbilical cord tissue–derived cells (UTCs) are MHC class I (MHCI) dull and negative for MHC class II (MHCII), but can be activated to increase MHCI and to express MHCII with IFN-γ stimulation. Mesenchymal stem cells with similar characteristics have been inferred to be nonimmunogenic; however, in most cases, immunogenicity was not directly assessed. Using UTC from Massachusetts General Hospital MHC-defined miniature swine, we assessed immunogenicity across a full MHC barrier. Immunogenicity was assessed by in vitro assays including mixed lymphocyte reaction (MLR) and flow cytometry to detect serum alloantibody. A single injection of MHC-mismatched unactivated UTCs did not induce a detectable immune response. When injected in an inflamed region, injected repeatedly in the same region or stimulated with IFN-γ prior to injection, UTCs were immunogenic. As clinical cellular repair strategies may involve injection of allogeneic cells into inflamed regions of damaged tissue or repeated doses of cells to achieve the desired benefit, our results on the immunogenicity of these cells in these circumstances may have important implications for optimal success and functional improvement for this cellular treatment strategy for diseased tissues.
HIV-1–induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo
Authors: Biancotto Angélique , Iglehart Sarah J. , Vanpouille Christophe , Condack Cristian E. , Lisco Andrea , Ruecker Elke , Hirsch Ivan , Margolis Leonid B. , Grivel Jean-Charles
Published: October 2007

We demonstrate mechanisms by which HIV-1 appears to facilitate its own infection in ex vivo–infected human lymphoid tissue. In this system, HIV-1 readily infects various CD4+ T cells, but productive viral infection was supported predominantly by activated T cells expressing either CD25 or HLA-DR or both (CD25/HLA-DR) but not other activation markers: There was a strong positive correlation (r = 0.64, P = .001) between virus production and the number of CD25+/HLA-DR+ T cells. HIV-1 infection of lymphoid tissue was associated with activation of both HIV-1–infected and uninfected (bystanders) T cells. In these tissues, apoptosis was selectively increased in T cells expressing CD25/HLA-DR and p24gag but not in cells expressing either of these markers alone. In the course of HIV-1 infection, there was a significant increase in the number of activated (CD25+/HLA-DR+) T cells both infected and uninfected (bystander). By inducing T cells to express particular markers of activation that create new targets for infection, HIV-1 generates in ex vivo lymphoid tissues a vicious destructive circle of activation and infection. In vivo, such self-perpetuating cycle could contribute to HIV-1 disease.
Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells
Authors: Illario Maddalena , Giardino-Torchia Maria L. , Sankar Uma , Ribar Thomas J. , Galgani Mario , Vitiello Laura , Masci Anna Maria , Bertani Francesca R. , Ciaglia Elena , Astone Dalila , Maulucci Giuseppe , Cavallo Anna , Vitale Mario , Cimini Vincenzo , Pastore Lucio , Means Anthony R. , Rossi Guido , Racioppi Luigi
Published: October 2007

Microbial products, including lipopolysaccharide (LPS), an agonist of Toll-like receptor 4 (TLR4), regulate the lifespan of dendritic cells (DCs) by largely undefined mechanisms. Here, we identify a role for calcium-calmodulin–dependent kinase IV (CaMKIV) in this survival program. The pharmacologic inhibition of CaMKs as well as ectopic expression of kinase-inactive CaMKIV decrease the viability of monocyte-derived DCs exposed to bacterial LPS. The defect in TLR4 signaling includes a failure to accumulate the phosphorylated form of the cAMP response element-binding protein (pCREB), Bcl-2, and Bcl-xL. CaMKIV null mice have a decreased number of DCs in lymphoid tissues and fail to accumulate mature DCs in spleen on in vivo exposure to LPS. Although isolated Camk4−/− DCs are able to acquire the phenotype typical of mature cells and release normal amounts of cytokines in response to LPS, they fail to accumulate pCREB, Bcl-2, and Bcl-xL and therefore do not survive. The transgenic expression of Bcl-2 in CaMKIV null mice results in full recovery of DC survival in response to LPS. These results reveal a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival.
Prediction of adverse outcomes in children with sickle cell anemia: a study of the Dallas Newborn Cohort
Authors: Quinn Charles T. , Lee Nancy J. , Shull Elizabeth P. , Ahmad Naveed , Rogers Zora R. , Buchanan George R.
Published: October 2007

The Cooperative Study of Sickle Cell Disease reported that dactylitis, severe anemia, and leukocytosis in very young children with sickle cell disease (SCD) increased the risk of later adverse outcomes, including death, stroke, frequent pain, and recurrent acute chest syndrome. This model has not been validated in other cohorts. We evaluated its performance in the Dallas Newborn Cohort, a newborn inception cohort of children with SCD. We studied 168 children (55% male, 97% sickle cell anemia) with a mean follow-up of 7.1 years who provided 1188 patient-years of observation. Of the 23 (13.7%) subjects who experienced adverse events, 2 (1.2%) died, 14 (8.3%) had a stroke, 4 (2.4%) had frequent pain, and 3 (1.8%) had recurrent acute chest syndrome. No relationship existed between early clinical predictors and later adverse outcomes, with the possible exception of leukocyte count. Most subjects who experienced adverse events were predicted to be at low risk for those events. No subject who was predicted to be at high risk actually experienced an adverse outcome. The sensitivity of the model did not rise above 20% until specificity fell below 60%. We suggest that this model not be used as a criterion to initiate early interventions for SCD.
Early peripheral blood blast clearance during induction chemotherapy for acute myeloid leukemia predicts superior relapse-free survival
Authors: Elliott Michelle A. , Litzow Mark R. , Letendre Louis L. , Wolf Robert C. , Hanson Curtis A. , Tefferi Ayalew , Tallman Martin S.
Published: October 2007

In childhood acute lymphoblastic leukemia (ALL), a rapid decline of circulating leukemic blasts in response to induction chemotherapy or prednisone is one of the most important prognostic factors, not only for achieving remission but also for relapse-free survival (RFS). However, in acute myeloid leukemia (AML) parameters of chemosensitivity have been restricted mainly to the rapidity of achievement of complete remission (CR) or the assessment of residual leukemic bone marrow blasts during aplasia. We hypothesized that the time to circulating peripheral blood blast clearance, as a potential surrogate for in vivo chemosensitivity, would have prognostic relevance in AML also. In a retrospective analysis of a cohort of 86 adult patients with AML receiving uniform induction and consolidation chemotherapy, we demonstrate that the time to clearance of circulating blasts during induction chemotherapy is an independent prognostic marker of RFS, superseding other known or established risk factors, including karyotype and number of inductions to achieve CR.