bluuebunny/crossref_metadata_2025 huggingface dataset:
Technology Adoption in Small-Medium Enterprises based on Technology Acceptance Model: A Critical Review
Authors: Nurqamarani Adisthy Shabrina , Sogiarto Eddy , Nurlaeli Nurlaeli
Published: November 2021

Background: Technology acceptance model (TAM) has been extensively used to analyse user acceptance of technologies adopted by enterprises at different levels. Moreover, the technology adoption has drawn attention among practitioners and academic communities alike, leading to the development of approaches to understand the concept. However, there is a degree of inconsistency found in previous studies on different types of TAM models used in explaining user acceptance of technologies among small-medium enterprises (SMEs).Objective: This critical literature review aims to synthesise the technology adoption scholarly studies using TAM. It is expected to aid the identification of the most relevant factors influencing SMEs in adopting technology. Additionally, analysing the variations of TAM developed in previous studies could provide suggested variables specific to the type of technology industry.Methods: An integrated approach was used, and this involves a review of articles on the adoption of technologies in SMEs from 2011 to 2021, retrieved from popular databases using a mixture of keywords such as technology acceptance model (TAM), technology adoption, and technology adoption in SMEs.Results: An overview of TAM studies on user acceptance of technology in this review covers a wide range of research areas from financial technology to human resource management-related technology. Perceived usefulness and perceived ease of use were discovered to be the most common factors in TAM from the 21 articles reviewed. Meanwhile, some other variables were observed such as context, type of technology and level of user experience.Conclusion: The review highlights key trends in previous studies on IT adoption in SMEs, which assist researchers and developers in understanding the most relevant factors and suitable TAM models in determining user acceptance in a particular field. Keywords: Technology Acceptance Model, Technology Adoption, Small-medium Enterprises, Critical Review
Pengembangan Lembar Kerja Peserta Didik Basis Hands on Activies dan Minds on Activities Pada Materi Alat Optik
Authors: Hadhiedae Ema Hainun , Miriam Sarah , Mahtari Saiyidah
Published: November 2021

LKPD berbasis Hands on Activity (HoA) dan Minds on Activity (MoA) belum tersedia, terutama pada materi alat optik. Penelitian dan pengembangan ini bertujuan menghasilkan LKPD berbasis HoA dan MoA pada materi alat optik serta mendeskripsikan validitas dan kepraktisannya. Penelitian ini merupakan penelitian pengembangan dengan model ADDIE. Objek penelitian ini ialah kualitas kelayakan LKPD berbasis HoA dan MoA yang dikembangkan berdasarkan kriteria validitas dan kepraktisan. Teknik pengumpulan data dilakukan melalui instrumen validitas pakar, wawancara dan kuesioner. Subjek uji coba pada penelitian ini adalah peserta didik kelas XI di salah satu SMA Banjarmasin. Data diperoleh dari validitas pakar dan lembar keterbacaan LKPD oleh peserta didik. Hasil penelitian menunjukkan bahwa: (1) validitas LKPD berbasis HoA dan MoA sebesar 3,39 dengan kategori valid dan (2) kepraktisan LKPD berbasis HoA dan MoA sebesar 75,48% dengan kategori praktis. Dengan demikian, disimpulkan bahwa LKPD alat optik berbasis HoA dan MoA layak digunakan dalam proses pembelajaran fisika. Penelitian ini diharapkan dapat menjadi referensi bagi guru atau tenaga pengajar dan membantu proses pembelajaran pada materi alat optik. Student worksheets based on hands-on and minds-on activities (HoA and MoA) are not yet available, specifically on the subject of optical instruments. This research focused on producing student worksheets based on HoA and MoA on optical instruments subject and describe its validity and practicality. This research is development research with the ADDIE model. The object of this research is the eligibility quality of student worksheets based on HoA and MoA, which was developed regarding its validity and practicality criteria. This development research uses the ADDIE model within student worksheets based on hands-on and minds-on activities as research subjects. The test subjects in this research were class XI students at one of the high schools in Banjarmasin. The data collection techniques were carried out by expert validation instruments, interviews and questionnaires. The data were obtained from expert validation and student worksheets readability sheets. This research showed that: (1) the validity of student worksheets based on HoA and MoA was 3,39, which in the valid category and (2) the practicality of student worksheets based on HoA and MoA was 75.48% which in the practice category. Thus, student worksheets based on HoA and MoA on optical instruments subject were eligible to be implemented in learning physics. This research is expected to be a reference for teachers and help the learning process on optical instrument subjects.
Pengembangan modul pembelajaran IPA SMP berbasis literasi sains pada materi sistem tata surya
Authors: Dwinanda Wahab Muhammad Novaldy Nur , Istyadji Maya , Putri Rizky Febriyani
Published: November 2021

Penelitian ini bertujuan untuk mendeskripsikan validitas modul pembelajaran IPA SMP berbasis literasi sains pada materi sistem tata surya berdasarkan penilaian para validator. Modul pembelajaran dikembangkan dengan model pengembangan 4D. Tetapi, pada penelitian ini hanya sampai pada tahap validasi. Instrumen yang digunakan pada penelitian ini adalah lembar validasi modul pembelajaran berbasis literasi sains, yang telah di validasi oleh lima orang validator. Teknik analisis yang digunakan adalah analisis validitas isi menurut Aiken’s V. sedangka kriteria valid yang digunakan berdasarkan tabel Aiken’s V adalah nilai indeks V yang didapat minimal berjumlah 0.87. Hasil penelitian yang diperoleh berdasarkan data hasil validasi menunjukkan bahwa modul pembelajaran berbasis literasi sains memiliki tingkat validitas yang sangat baik ditinjau dari lima aspek: 1) kelengkapan penyajian buku memperoleh skor 0.96 kriteria sangat valid, 2) kelayakan isi memperoleh skor 0.90 kriteria sangat valid, 3) teknik penyajian memperoleh skor 0.98 kriteria sangat valid, 4) bahasa memperoleh skor 0.93 kriteria sangat valid, dan 5) literasi sains memperoleh skor 0.84 juga dengan kriteria sangat valid. Berdasarkan hasil penelitian yang diperoleh, dapat disimpulkan modul pembelajaran IPA SMP berbasis literasi sains pada materi sistem tata surya yang dikembangkan oleh peneliti dinyatakan valid pada kelima aspek tersebut. Peneliti berkeyakinan bahwa modul pembelajaran yang dikembangkan ini dapat memfasilitasi guru dalam proses pembelajaran dan diharapkan dengan modul pembelajaran yang dikembangkan ini peserta didik juga dapat memahami dan menguasai pembelajaran IPA terpadu dengan lebih mudah.
Persepsi Peserta Didik dalam Pembelajaran Blended Learning Pada Mata Pelajaran Fisika di Tingkat SMA
Authors: Putri Rahma Kurnia , Purwanto Andik , Connie Connie
Published: November 2021

Blended Learning sebagai model pembelajaran di lembaga pendidikan yang mengkombinasikan pembelajaran campuran yaitu offline dengan online. Adanya penelitian ini yang tujuannya mendeskripsikan persepsi peserta didik pada model Blended Learning mata pelajaran Fisika khususnya pada masa pandemi Covid-19, sehingga menjadi bahan evaluasi dalam implementasi Blended Learning di sekolah. Jenis penelitiannya adalah deskriptif. Tempat pelaksanaannya di salah satu SMA Kota Bengkulu. Sampel penelitian berjumlah 20 peserta didik dipilih dari 95 peserta didik kelas XI MIPA 1-3, melalui teknik simple random sampling. Instrumen penelitian berupa angket persepsi dan lembar observasi. Angket persepsi yang dirancang sebanyak 30 butir dengan tingkat reliabilitas angket sebesar (0,736) dengan kategori baik. Teknik analisis penelitian ini memakai metode analisis deskriptif serta pendekatan kuantitatif. Penelitian menghasilkan bahwa persepsi peserta didik sangat beragam dan mendapatkan suport yang positif dari semua aspek/pihak tentang persepsi peserta didik terhadap pembelajaran Blended Learning pada mata pelajaran Fisika.   Blended learning as a learning model in educational institutions that composite blended learning, online educational materials and opportunities for interaction online with traditional place-based classroom methods. This study aims to describe student perceptions of the blended learning model in physical subjects, especially during the Covid-19 pandemic, to become an evaluation material in implementing Blended Learning in schools. This type of research is descriptive. The place of implementation is in one of the Bengkulu City High Schools. The research sample amounted to 20 students selected from 95 class XI MIPA 1-3 through a simple random sampling technique. The research instrument is in the form of a perception and observation sheet. In the form of perception questions, designed as many as 30 items with a questionnaire reliability level of (0.736) with a good category. In the analysis methodology of this study, the descriptive analysis method and quantitative approaches are used. The study found if students will receive positive support in all aspects of how students perceive Blended Learning in physics.
Perbandingan Kepuasan Siswa terhadap Pembelajaran Fisika Sistem Online dengan Menggunakan Smartphone dan Laptop
Authors: Putra Nurhamdin , Syarkowi Ahmad
Published: November 2021

Penelitian ini bertujuan untuk menganalisis perbandingan kepuasan siswa terhadap pembelajaran fisika secara online antara siswa yang belajar dengan menggunakan smartphone dan siswa yang menggunakan laptop. Jenis penelitian yang dilakukan adalah penelitian kuantitatif dimana metode yang digunakan adalah survei. Pada penelitian ini pengambilan data dilakukan dengan cara membagikan kuisioner kepada responden melalui google formulir. Sampel dalam penelitian ini diambil dengan menggunakan teknik Convenience Sampling dimana siswa tingkat SMA dan MA jurusan IPA dari 8 sekolah di Provinsi Bengkulu yang mengisi kuisioner sebagai sampelnya. Dari kuisioner yang dibagikan diperoleh data sebanyak 525 responden. Data yang diperoleh akan dianalisis dengan menggunakan Uji Mann Whitney dikarenakan data tidak berdistribusi normal. Berdasarkan analisis data yang telah dilakukan diperoleh hasil signifikansi perhitungan p-value sebesar 0,808 lebih besar dari 0,05. Dari hasil ini, dapat dikatakan bahwa tidak terdapat perbedaan yang signifikan antara tingkat kepuasan siswa yang menggunakan Smartphone dan siswa yang menggunakan laptop dalam pembelajaran fisika sistem online. Sehingga, dapat disimpulkan dalam pembelajaran fisika secara online baik siswa yang menggunakan Smartphone maupun laptop memperoleh kepuasan yang hampir sama, dengan tingkat kepuasan terkategori puas. This study aims to compare student satisfaction with online physics learning between students who study using smartphones and students who use laptops. This type of research is quantitative research, where the method used is a survey. In this study, data collection was carried out by distributing questionnaires to respondents via google forms. The sample in this study was taken using the technique Convenience Sampling, where high school and MA level students majoring in science from 8 schools in Bengkulu province filled out questionnaires as samples. From the questionnaires, distributed data obtained as many as 525 respondents. The data obtained will be analyzed using the Mann Whitney test because the data is not normally distributed. Based on the data analysis that has been carried out, the calculation results of the significance of the p-value of 0.808 are greater than 0.05. From these results, it can be said that there is no significant difference between the level of satisfaction of students who use smartphones and students who use laptops in online learning physics. So, it can be concluded that in online physics learning, both students who use smartphones and laptops get almost the same satisfaction, with the level of satisfaction categorized as satisfied.
POR OUTRA ECO(LOGIA)NOMIA E SUSTENTABILIDADE
Authors: Rodrigues Xavier da Cruz Uilmer , Alexandrino Garcia Ricardo
Published: November 2021

O grande processo de industrialização vem trazendo consequências como os diversos problemas sociais, além de questões ecológicas que estão relacionadas ao esgotamento dos recursos naturais. Nesse sentido, é importante se pensar em formas de diminuir os impactos sociais e ecológicos, advindos dessas práticas, no futuro. A partir daí é que surge o conceito de sustentabilidade, como uma possibilidade de conectar a economia, o bem-estar social e do meio ambiente. Portanto, este trabalho buscou estabelecer um diálogo, sob a luz de autores como Pádua (2005, Gonçalves (2018) e Grzybowski (2011), dentre outros, que abordam os fenômenos da realidade através do olhar da Ciência Geográfica e a partir de reflexões e definições de suma importância para os dias de hoje. Dentre essas reflexões, tem-se o estudo dos territórios sócio-espaciais nos contextos políticos e sociais que advém da relação entre o homem e a natureza. Também são apresentados os conceitos do “Novo Realismo Ecológico” “Iniquidade Global”, “Enfoque Flutuante”, “biocivilização” etc. Sendo assim, foi possível concluir que o Brasil precisará dos recursos naturais, presentes na diversidade de seu território, para combater sua dívida social. Contudo, para que esse enfrentamento não prejudique o meio ambiente, será preciso também criar mecanismos que superem a superficialidade mencionada no enfoque flutuante, priorizando a preservação ao meio ambiente.
ANÁLISE DA SUSTENTABILIDADE DA PRESTAÇÃO DOS SERVIÇOS DO SISTEMA DE ABASTECIMENTO DE ÁGUA NO MUNICÍPIO DE BELÉM-PA
Authors: Souza Arllen Augusto Gomes , Nylander João Diego Alvarez , Pereira José Almir Rodrigues
Published: November 2021

Este trabalho analisa a sustentabilidade da prestação dos serviços do Sistema de Abastecimento de Água (SAA) do município de Belém, estado do Pará, Brasil. A pesquisa foi realizada em três etapas. Na primeira delas, foram obtidas informações do planejamento do sistema existente, em seguida, foram pesquisados e sistematizados dados técnicos, operacionais e econômicos da prestação do serviço e, por fim, avaliou-se a sustentabilidade econômica, social e ambiental do abastecimento de água no município de Belém. Os resultados apontam que, dos 1.485.732 habitantes belenenses, 441.309 dos não foram atendidos com abastecimento de água no ano 2018 segundo os dados do Sistema Nacional de Informações Sobre Saneamento (SNIS). Além disso, constatou-se que a redução do volume perdido de água não foi realizada como estabelecido no Plano Municipal de Saneamento Básico (PMSB) elaborado em 2014. Essa situação contribuiu para a diferença negativa de R$ 32.726.900,76 entre o valor total arrecadado (R$ 161.550.822,88) e a despesa de exploração (R$ 194.277.723,64) no ano de 2018, demonstrando que a prestação do serviço não teve sustentabilidade econômica. Diante disso, é possível concluir que a atualização do PMSB de Belém e a realização de ações para melhorar a gestão operacional são essenciais para o esforço de atingir a meta de 99% da população de Belém atendida com água potável até o ano 2033, conforme estabelecido na Lei 14.026/2020.
MERCADOS PÚBLICOS COMO PATRIMÔNIO CULTURAL
Authors: Pereira Azenaide Lopes , Kunz Sidelmar Alves da Silva , Franco Maira Vieira Amorim
Published: November 2021

O conceito de mercado público como suporte de preservação de patrimônio cultural revela que os espaços destinados a gerar economia, subsistência e socialização, produzindo também cultura, geram por sua vez a historicidade e revelam os modos como as pessoas fazem ou criam objetos, artefatos, músicas, comidas, entre outros elementos que caracterizam a identidade cultural de determinado lugar. Este trabalho tem por objetivo realizar uma análise documental histórica, no sentido de abordar a história do surgimento dos mercados públicos na cidade de Goiânia, considerando que esses espaços são partes vivas da cultura e da história da comunidade, sobretudo com uma função socioeconômica para a sociedade, e que precisam de políticas voltadas para a preservação desses patrimônios culturais. Metodologicamente, fez-se necessária uma análise documental histórica, tendo como fontes arquivos públicos de Órgãos da Prefeitura de Goiânia e do IPHAN/DF, e a revisão bibliográfica de diferentes temas: Mercado público, Marcha para Oeste, fundação de Goiânia, feiras e patrimônio cultural, entre outros. Buscou-se, desse modo, contribuir para a discussão de políticas públicas que implementem ações de valorização dos mercados e a continuidade das atividades, oferecendo condições de trabalho para os permissionários que dele tiram seu sustento.
Komunikasi Pemasaran Wisata Halal Di Banyuwangi dan Gunungkidul
Authors: Tri Wijayanti Yani
Published: November 2021

The concept of Halal Tourism began to be adopted in Indonesia in 2014 and is getting stronger in Indonesia following the 2016 World Halal Tourism Award in Dubai. Several regions or districts responded to this by opening halal tourism, including Banyuwangi Regency and Gunungkidul Regency. Banyuwangi Regency launched tourist area branded as ‘the first sharia beach tourism in Indonesia’, namely Santen Island Beach. Meanwhile, Gunungkidul Regency is on Torohudan Beach. The research method used is a case study. The discussion includes marketing strategy and marketing communication mix, showing the implementation of halal tourism management on Santen Island Beach was successful at the beginning with very strong branding evidence, marketing communication practices have maximized marketing strategy and communication mix. At Torohudan Beach, the community prefers the principle of ‘Muslim friendly tourism’, and in its implementation it needs support from the local government. Keywords: branding, Halal Tourism, muslim friendly tourism, sharia beach tourism
Experimental Estimation of Deviation Frequency Within the Spectrum of Scintillations of the Carrier Phase of GNSS Signals
Authors: Demyanov Vladislav , Danilchuk Ekaterina , Yasyukevich Yury , Sergeeva Maria
Published: November 2021

The term deviation frequency denotes the boundary between the variable part of the amplitude and phase scintillation spectrum and the part of uninformative noises. We suggested the concept of the “characteristic deviation frequency” during the observation period which is defined as the most probable value of the deviation frequency under current local conditions. This work is a case study of the characteristic deviation frequency (fd) registered for GPS, GLONASS, Galileo and SBAS signals under quiet and weakly disturbed geomagnetic conditions in April 2021 at the mid-latitude GNSS station. Our results demonstrated that the fd value for all signal components of GPS, GLONASS and GALILEO signals varied within 15-22 Hz. The characteristic deviation frequency was 20 Hz for the mentioned GNSS signals. In difference, the deviation frequency was limited within 13-20 Hz for SBAS with the lower characteristic deviation frequency at 18 Hz. We assume that the concept of the characteristic deviation frequency can be used to determine the optimal sampling rate of the GNSS carrier phase data for the ionospheric studies. The characteristic deviation frequency can also characterize the state of the regular trans-ionospheric radio channel.
Halogen-Furan-2(5H)-One Derivatives Decrease Biofilm Production in Pseudomonas aeruginosa.
Authors: Aburto-Rodríguez Nelly Araceli , García-Contreras Rodolfo , Castillo-Juárez Israel , Castro-Torres Victor Alberto , Martínez-Vázquez Mariano
Published: November 2021

Clinical evidence has shown that bacterial infections are more difficult to eradicate when form-ing a biofilm aggregate than when are produced by bacteria in planktonic form. Therefore, com-pounds that inhibit biofilm formation could be used against severe infections. It has been re-ported that bromo 2-(5H) furanones inhibited biofilm formation by their anti-quorum sensing properties. To determine if the 2-(5H) furanone moiety is essential to induce inhibition of biofilm formation, we evaluated ten halogen 2-(5H) furanones derivates previously synthesized. Besides evaluating the inhibition of biofilm formation, we assessed pyocyanin production, swarming motility, and transcription of essential QS genes: rsaL, rhlA, pqsA and phz1 genes. Our results showed that although three bromo-furan-2(5H)-one-type derivatives (A1-A3) and two bromo-4-(phenylamino)-furan-2(5H)-one-type compounds (B2 and B6) inhibited the biofilm formation in both P. aeruginosa PA14 (reference) and PA64 (drug-resistant) strains only the furanones A1-A3 were efficient to inhibit QSS.
Dealing with the Ambiguity of Glycan Substructure Search
Authors: Daponte Vincenzo , Hayes Catherine , Mariethoz Julien , Lisacek Frederique
Published: November 2021

The level of ambiguity in describing glycan structure has significantly increased with the upsurge of large scale glycomics and glycoproteomics experiments. Consequently, an ontology-based model appears as an appropriate solution for navigating this data. However, navigation is not sufficient and the model should also enable advanced search and comparison. A new ontology with a tree logical structure is introduced to represent glycan structures irrespective of the precision of molecular details. The model heavily relies on the GlycoCT encoding of glycan structures. Its implementation in the GlySTreeM knowledge base was validated with GlyConnect data and benchmarked with the Glycowork library. GlySTreeM is shown to be fast, consistent, reliable and more flexible than existing solutions for matching parts of or whole glycan structures. The model is also well suited to painless future expansion. Availability:https://glyconnect.expasy.org/glystreem/wiki
Social Network-Based Digital Stroke Prevention: Opportunities, Results and Prospects
Authors: Demkina A. E. , Bezzubtseva M. V. , Ryabinina M. N. , Kotlyar Ya. A. , Keln O. L. , Sarapulova А. V. , Zhetishev R. R. , Kuvaev V. S. , Maksimova M. Y. , Pogosova N. V. , Zhetisheva I. V.
Published: November 2021

Aim. To study the possibilities and limitations of the social network as a digital medical tool, which is aimed at improving programs for primary and secondary stroke prevention in young people.

Material and methods. The study was carried out in the format of online training for volunteers. At the first stage of the work, the online school “Stroke in Young People” was announced in 8 medical blogs. As part of the school, a special account was created for readers (n=1354). At the second stage, 49 respondents (4% of men, whose average age was 24.4±5.2 years) were selected from 1354 listeners, who were surveyed on “Awareness of risk factors and stroke symptoms among users of social networks” before and after the online school.

Results. The online school audience is predominantly female (91%), and 43% of readers were in the 25-34 age group. The total number of people who listened to and read the online school material is 8712 people. 17% worked in the healthcare system, and 22% of respondents had a history of stroke. 38 (78%) people of the 2nd stage among the respondents independently searched for information about stroke earlier, and 30 (61%) received this information passively from medical workers in 2020. Before the online school start, the majority of respondents (over 60%) were aware of 2 out of 7 stroke risk factors (dyslipidemia and arterial hypertension) and 3 out of 6 stroke signs (drooping of the face half, weakness in the limbs and difficulty speaking). Less than 40% of the participants considered the stroke risk factors for diabetes mellitus, other cardiovascular diseases (CVD), obesity, and alcohol use; less than 20% were aware of stroke symptoms such as impaired vision and coordination and very severe headache. After completing online learning, the greatest increase in knowledge was found among the following risk factors – smoking and other CVDs (p<0.05); stroke symptoms - headache and drooping of the face half (p<0.05).

Conclusion. The online school aroused interest among healthcare workers and people without medical education, including those with stroke. Most of the respondents believed that they knew how to prevent a stroke (over 80%) and would be able to provide first aid to a person with a stroke (over 90%). At the same time, the awareness of risk factors and stroke symptoms was low prior to the start of learning, even though the study included healthcare workers and stroke survivors. Online learning has led to increased awareness of some risk factors and stroke symptoms. Social media can be one of the tools for medical prevention of stroke in young people, but program planning should take into account the way the material is presented and its readability.
Pharmacogenetic Aspects of Postoperative Anesthesia with Ketoprofen in Cardiac Surgery Patients
Authors: Morozova T. E. , Shatsky D. A. , Shikh N. V. , Shikh E. V. , Andrushchyshina T. B. , Lukina M. V. , Kachanova A. A. , Sozaeva Z. A. , Shuev G. N. , Denisenko N. P. , Grishina E. А. , Sychev D. A.
Published: November 2021

Aim. Evaluation of the effect of polymorphisms of the CYP2D6, CYP2C8 genes on the efficacy and safety of postoperative analgesia with ketoprofen in patients with coronary artery disease after cardiac surgery.

Material and methods. The study included 90 patients with an established diagnosis of coronary artery disease and postoperative period after cardiac surgery. Patients received ketoprofen 100 mg intramuscularly 2 times a day for 5 days. The intensity of pain was rated by Numeric Rating Scale. The severity of dyspepsia was assessed by the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. DNA was isolated from venous blood using an automated system. Single nucleotide polymorphisms CYP2C8 (C>T) rs11572080, CYP2D6*4 (1846G>A) rs3892097 were determined by the real-time polymerase chain reaction method.

Results. In patients with genotypes GA and GG for the allelic variant CYP2D6*4, significant differences in the intensity of pain syndrome were found on days 4 and 5 of the postoperative period: 3,91±2,17 and 4,95±1,8 points (p=0,04), 3,52±1,95 and 4,5±1,7 points (p=0,04) in patients with GA and GG genotypes on days 4 and 5, respectively. In patients with the CT genotype for the CYP2C8 rs11572080, the severity of dyspepsia by GSRS was significantly higher than in patients with the CC genotype: 22,67±7,64 and 18,97±4,25 points, respectively.

Conclusion. Patients with the GA genotype for the CYP2D6*4 allelic variant showed a lower intensity of pain syndrome than the GG genotype. In patients with the CT genotype for the CYP2C8 rs11572080, higher dyspepsia was revealed than in the CC genotype.
Peculiarities of Adverse Events Manifested by Injury of Skin and Skin Derivatives and Associated with Beta-blockers Use
Authors: Matveev A. V. , Egorova E. A. , Konyaeva E. I. , Dormidor A. G. , Bekirova E. Yu.
Published: November 2021

More than 50 years after Propranolol was introduced to the pharmaceutical market as a drug that can lower the heart rate, beta-blockers (BAB) are still widely used in the pharmacotherapy of cardiovascular diseases. However, the use of BAB has a number of limitations, first of all, due to adverse drug events (AE) that develop during their use. The purpose of our review was to study the features of the BAB AE manifested by injuries of the skin and its appendages. The clinical manifestations of them are the development or exacerbation of psoriasis, lichen planus, contact dermatitis, acrocyanosis, Raynaud's disease, alopecia, hyperhidrosis, vitiligo, anaphylaxis, and allergic skin reactions. True medicinal psoriasis occurs in patients taking BAB with no family or previous history and most often mimics erythrodermic psoriasis and palmar-plantar pustular psoriasis. Systemic use of BAB can also be accompanied by exacerbation of vitiligo. In patients with segmental vitiligo, the results of Doppler flowmetry and iontophoresis showed increased blood flow in vitiligo foci compared with normal skin. The development of anaphylactic reactions against the background of BAB therapy may be due to the modulation of adenylate cyclase, which can affect the release of anaphylactogenic mediators, as well as a decrease in the severity of cardiovascular compensatory changes. The peculiarities of the development of such reactions may be the resistance of patients to traditional treatment, which is due to the development of paradoxical reflex vagotonic effects when using adrenaline. Some of the mentioned AE may pose a potential threat to the life and health of the patient and therefore require additional discussion.
New Indicators of Myocardial Work in Healthy Individuals
Authors: Oleynikov V. E. , Babina A. V. , Galimskaya V. A. , Golubeva A. V. , Makarova K. N. , Donetskaya N. A.
Published: November 2021

Aim. To study in healthy individuals the gender and age characteristics of left ventricular (LV) myocardial work indicators, their correlations with global LV deformity indicators and echocardiographic parameters characterizing LV systolic and diastolic functions.

Materials and methods. 70 Healthy individuals (n=70; 34 men and 36 women; aged 39.3±8.9 years) were included in the study. The echocardiographic examination determined the standard parameters and indicators of myocardial work: global work efficiency (GWE), global constructive work (GCW), global wasted work (GWW), global myocardial work index (GWI); as well as the myocardium deformation characteristics: global longitudinal deformation (GLS), global radial deformation (GRS) and global circular deformation (GCS). Spearman's correlation coefficient was used to investigate the relationship between parameters. A correlation was considered weak at r≤0.3, moderate at 0.3<r<0.7, and strong at r≥0.7.

Results. The average value of global work efficiency (GWE) in men was 97% (96; 98), in women – 98% (97; 98). Global constructive work (GCW) in men was 2343.8±350.4 mm Hg%, in women – 2362.2±343.8 mm Hg%. The average value of global wasted work (GWW) in men was 46 mm Hg% (27; 75), in women – 44 mm Hg% (33; 55.5). The global myocardial work index (GWI) in men was 2069.9±356.4 mm Hg%, in women – 2055.7±339.9 mm Hg%. No significant differences were found in the comparative analysis of performance indicators. The analysis of correlations found that the myocardial work indicators didn't have significant correlations with age. Ejection fraction was moderately correlated with GWI (r=0.45) and GCW (r=0.49). Global longitudinal strain was strongly correlated with GWI (r=0.77) and GCW (r=0.77). Global radial strain correlated moderately directly with GWI (r=0.4) and GCW (r=0.4). Global circular strain was moderately correlated with GCW (r=0.35). A strong negative correlation was found between the GWE indicator and the post systolic contraction index (PSI) (r=-0.85). At the same time, PSI and GWW had a strong positive correlation (r=0.85).

Conclusion. Indicators of LV myocardial work in healthy individuals do not have gender differences. The efficiency of the work of the myocardium depends primarily on the deformation of the LV, while the constructive work is determined by the volume characteristics. The wasted work indicator depends on the number of segments that peak in the post-systolic period.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 30.10. по 05.11.2021 г.
Authors: Дмитриева Людмила , Чумачкова Елена , Краснов Ярослав , Осина Наталья , Сафронов Валентин , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: November 2021

В обзоре представлен анализ геновариантов вируса SARS-CoV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе их геномов в базе GISAID за неделю с 30.10.2021 г. по 05.11.2021 г.
Buku Ajar Micro Teaching
Authors:   Yuli Astutik, Megawati Fika
Published: November 2021

Alhamdulillah, puji syukur kepada Allah SWT, sehingga Buku Ajar Micro Teaching ini dapat disusun dengan baik meskipun perlu penyempurnaan lebih lanjut. Micro Teaching merupakan mata wajib kuliah di Program Studi Pendidikan Bahasa Inggris. Buku ajar Micro Teaching ini dikhususkan untuk pegangan Mahasiswa semester 6. Tidak terdapat mata kuliah prasarat yang harus diselesaikan sebelum mengambil mata kuliah ini. Penulisan buku ajar Micro Teaching ini ditulis dalam 4 bab yang berisi: Chapter 1 Micro Teaching Dalam bab 1 ini dijelaskan tentang definisi Micro Teaching dan perbedaannya dengan real teaching. Chapter 2 Lesson Planning Dalam bab 2 dijelaskan cara menyusun lesson plan mata pelajaran Bahasa Inggris pada level SMP dan SMA/SMK. Chapter 3 Teaching Strategies Dalam bab 3 ini dijelaskan tentang variasi strategi pembelajaran Bahasa Inggris yang meliputi empat keterampilan, Listening, Speaking, Reading, and Writing dan diintegrasikan dengan teknologi. Penulis menyampaikan terima kasih khususnya kepada: Hidayatulloh, M.Si yaitu Rektor Universitas Muhammadiyah Sidoarjo yang telah memberikan dan memfasilitasi dalam penulisan buku ajar ini. DRPM Universitas Muhammadiyah Sidoarjo yang telah memfasilitasi dan mengkoordinasi dalam penulisan buku ajar ini. Akhtim Wahyuni, M.Ag. sebagai Dekan Fakultas Psikologi dan Ilmu Pendidikan, Universitas Universitas Muhammadiyah Sidoarjo. Akhir kata, saran perbaikan sangat diharapkan untuk penyempurnaan buku ajar ini. Harapan kami semoga buku ajar ini dapat digunakan sebagai tambahan informasi dan bermanfaat bagi aktivitas pembelajaran mata kuliah Micro Teaching di Program Studi Pendidikan Bahasa Inggris, Universitas Muhammadiyah Sidoarjo.
Buku Ajar Filsafat Sains
Authors:   Septi Budi Kartika, Efendi Nur
Published: November 2021

Menjadikan seseorang menjadi bijaksana dalam menyikapi persoalan kehidupan serta membimbing manusia dalam menyelesaikan persoalan kehidupan melalui proses berpikir dinamakan filsafat. Filsafat merupakan suatu proses berpikir manusia yang mengarahkannya supaya dirinya dapat menjadi arif dan bijaksana dalam menghadapi kehidupan, artinya filsafat dapat membimbing dan mengarahkan manusia dalam menyelesaikan permasalahn hidup yang belum mendapatkan pemecahannya.Dalam filsafat, terkandung permasalahan sebagai berikut: Pengkajian teori yang sesuai dengan kenyataan yang ada, dinamakan masalah epistemologis. Pengkajian sebuah metode atau cara yang dilakukan dalam memeroleh ilmu pengetahuan, dinamakan masalah metodologis. Pengkajian segala sesuatu yang berkaitan dengan alam baik yang tampak maupun kasat mata, misal berpikir bagaimana Tuhan menciptakan bumi dan alam semesta, seperti pemikiran seorang filsuf ternama yaitu Thales, dinamakan masalah metafisika. Pengkajian persoalan tentang cara memeroleh ilmu pengetahuan secara sadar sehingga diperoleh kesimpulan yang dapat dipertanggungjawabkan kebenarannya, dinamakan masalah logika. Pengkajian persoalan mengenai perilaku baik dan buruk manusia, dinamakan masalah etika. Pengkajian persoalan tentang keindahan melalui indera manusia yang dapat diapresiasikan ke dalam karya seni yang baik, dinamakan masalah estetika.
Intermedin1-53 Inhibits NLRP3 Inflammasome Activation by Targeting IRE1α in Cardiac Fibrosis
Authors: Zhang Lin-Shuang , Zhang Jin-Sheng , Hou Yue-Long , Lu Wei-Wei , Ni Xian-Qiang , Lin Fan , Liu Xiu-Ying , Wang Xiu-Jie , Yu Yan-Rong , Jia Mo-Zhi , Tang Chao-Shu , Han Ling , Chai San-Bao , Qi Yong-Fen
Published: November 2021

Intermedin (IMD), a paracrine/autocrine peptide, protects against cardiac fibrosis. However, the underlying mechanism remains poorly understood. Previous study reports that activation of Nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome contributed to cardiac fibrosis. In this study, we aimed to investigate whether IMD mitigates cardiac fibrosis by inhibiting NLRP3. Cardiac fibrosis was induced by angiotensin II (Ang II) infusion for 2 weeks in rats. Western blot, real-time PCR, histological staining, immunofluorescence assay, RNA sequencing, echocardiography and hemodynamics were used to detect the role and the mechanism of IMD in cardiac fibrosis. Ang II infusion resulted in rat cardiac fibrosis, shown as over-deposition of myocardial interstitial collagen and cardiac dysfunction. Importantly, NLRP3 activation and endoplasmic reticulum stress (ERS) was found in Ang II treated rat myocardium. Ang II infusion decreased the expression of IMD and increased the expression of the receptor system of IMD in the fibrotic rat myocardium. IMD treatment attenuated the cardiac fibrosis and improved cardiac function. In addition, IMD inhibited the upregulation of NLRP3 markers and ERS markers induced by Ang II. In vitro, IMD knockdown by small interfering RNA significantly promoted the Ang II-induced cardiac fibroblast and NLRP3 activation. Moreover, silencing of inositol requiring enzyme 1 α (IRE1α) blocked the effects of IMD inhibiting fibroblast and NLRP3 activation. Pre-incubation with PKA pathway inhibitor H89 blocked the effects of IMD on the anti-ERS, anti-NLRP3 and anti-fibrotic response. In conclusion, IMD alleviates cardiac fibrosis by inhibiting NLRP3 inflammasome activation via suppressing IRE1α and cAMP/PKA pathway.
Ranking the Return on Assets of Tehran Stock Exchange by New Method Based on Z-numbers Data
Authors: Farzam Maryam , kermani Mozhdeh Afshar , Allahviranloo Tofigh
Published: November 2021

Since real-world data is often inaccurate and working with fuzzy data and Z-numbers are very important and necessary, in the real world we need to rank and compare data. In this paper, we introduce a new method for ranking Z-numbers. This ranking algorithm is based on centroid point.We evaluate distance between centroid point, and based on this distance, we rank the Z-numbers.We use this method in two practical examples. First in ranking the return on assets of Tehran stock exchange, and second, in ranking of factors affecting the productivity of tourism security.The advantage of this method over conventional fuzzy methods is considering uncertainty, and allocating credit in the opinion of experts to estimate fuzzy parameters.
In vitro comparison of the cytotoxicity of different endodontic sealers; AH Plus, AdSeal, Endoseal MTA, and GuttaFlow Bioseal
Authors: Dastorani Mehdi , Aliee Muhammad javad , Halabian Raheleh , Solati Mostafa , Alemrajabi Mohammadsadegh
Published: November 2021

Background: This study aimed to assess the cytotoxicity of four commonly used endodontic sealers namely AH Plus, AdSeal, Endoseal MTA, and GuttaFlow Bioseal against human gingival fibroblasts (HGFs). Methods: After culturing the HGFs, they were exposed to the respective sealers in set form and in five different weights, after sterilization. The cytotoxicity of the sealers was evaluated after 1, 3 and 7 days using the methyl thiazolyl tetrazolium (MTT) assay. Data were analyzed by repeated measures ANOVA. Results: After 24 h, all sealers showed low cytotoxicity. However, all sealers in 250 mg and 500 mg weights showed significantly higher cytotoxicity than the negative control group at 72 h, and 7 days (P<0.05) except for AdSeal in 80 mg weight (P>0.05). AH Plus was significantly more cytotoxic than other sealers at 3 and 7 days (P<0.05) while AdSeal had the closest results to the negative control group, and showed significantly higher biocompatibility than other sealers in 250 mg concentration. Conclusion: AdSeal showed the highest biocompatibility while AH Plus had the highest cytotoxicity among the tested sealers. Thus, its application may delay the healing of periapical lesions.
The anti-tumor effect of stigmasterol on sorafenib treated human breast cancer cell lines
Authors: elshamy asmaa , Omran Gamal , Abd-Alhaseeb Mohammad , Houssen Maha
Published: November 2021

Background: Breast cancer is the most common invasive malignancy and the leading cause of tumor-related death among women globally. Excessive angiogenesis, sustained proliferation, and evasion of apoptosis are crucial for breast cancer progression. Sorafenib is a multi-kinase receptor inhibitor with anti-angiogenic activity. Stigmasterol is a phytosterol with anticancer activity. The aim of this study was to investigate molecular mechanisms of action of sorafenib and stigmasterol in two different human breast cancer cell lines and assess their combined impact on modulation of signaling pathways that control breast cancer pathogenesis. Methods and results: MCF-7 and MDA-MB 231 cells were used as models of human breast cancer. MTT assay was used to assess cytotoxicity. Angiogenic VEGF/ VEGFR-2/ ERK/ NF-kB signaling pathway was investigated using ELISA and RT-PCR techniques. Apoptotic markers (caspase-3, Bcl2) and a proliferation marker (Ki-67) were assessed using colorimetric and ELISA techniques. Sorafenib combined with stigmasterol increased caspase-3 activity and decreased Bcl2, VEGF-A, VEGFR-2, NF-kB and Ki-67 levels. Conclusion: The combination of Sorafenib and stigmasterol may be a useful therapeutic regimen for breast cancer treatment. This combination may inhibit angiogenesis and promote apoptosis signaling.
Untangling the changing impact of non-pharmaceutical interventions and vaccination on European Covid-19 trajectories
Authors: Ge Yong , Zhang Wenbin , Wu Xilin , Ruktanonchai Corrine , Liu Haiyan , Wang Jianghao , Song Yongze , Liu Mengxiao , Yan Wei , Cleary Eimear , Qader Sarchil , Atuhaire Fatumah , Ruktanonchai Nick , Tatem Andrew , Lai Shengjie
Published: November 2021

Non-pharmaceutical interventions (NPIs) and vaccination are two fundamental approaches to mitigate the coronavirus disease 2019 (Covid-19) pandemic. Vaccination strategies are generally less costly and socially/economically disruptive than NPI strategies, such as business closures, social distancing, and face mask mandates, as evidenced by highly vaccinated countries generally rolling back NPIs. However, the respective real-world impact of an NPI strategy versus vaccination strategy, or the combination of both, on mitigating Covid-19 transmission remains uncertain. To address this, we built a Bayesian inference model to explore the changing effectiveness of NPIs and vaccination based on the assembled large-scale dataset, including epidemiological parameters, variants, vaccines, and control variable. Here we show that NPIs were still considerably complementary or even synergistic to vaccination in the effort to curb the Covid-19 infection before reaching herd immunity. We found that (1) the synergistic effect of NPIs and vaccination was 46.9% (reduction in reproduction number) in September 2021, whereas the effects of NPIs and vaccination alone were 20.7% and 28.8%, respectively; (2) effectiveness of NPIs is less sensitive to emerging COVID-19 variants but decreases with vaccination progress, as NPIs may unnecessarily restrict the vaccinated population. The effectiveness of NPIs alone declined approximately 23% since the introduction of vaccination strategies, where the relaxation of NPIs promoted the decline from May 2021. Our results demonstrate that the decision to relax NPIs should consider the real-world vaccination rate of the relevant population, which is determined by the observed vaccine efficacy in relation to extant and emerging variants.
Low prevalence of Plasmodium falciparum parasites lacking pfhrp2/3 genes among asymptomatic and symptomatic school-age children in Kinshasa, Democratic Republic of Congo
Authors: Nundu Sabin , Arima Hiroaki , Simpson Shirley , Chitama Ben-Yeddy Abel , Munyeku Yannick Bazitama , Muyembe Jean-Jaques , Mita Toshihiro , Ahuka Stve , Culleton Richard , Yamamoto Taro
Published: November 2021

Background. Loss of efficacy of malaria diagnostic tests may lead to untreated or mistreated cases, compromising case management and control. There is an increasing reliance on rapid diagnostic tests (RDTs), with the most widely used of these targeting the Plasmodium falciparum histidine-rich protein 2 gene. There are numerous reports of the deletion of this gene in P. falciparum parasites in some populations, rendering them undetectable by PfHRP2 RDTs. We aimed to identify P. falciparum parasites lacking the P. falciparum histidine rich protein 2 and 3 genes isolated from asymptomatic and symptomatic school-age children in Kinshasa, Democratic Republic of Congo. Methods. We assessed the performance of PfHRP2-based RDTs in comparison to microscopy and PCR. PCR was then used to identify parasite isolates lacking pfhrp2/3 genes. Results. Of 462 DNA samples analysed, deletions of the pfhrp2 and pfhrp3 genes were found in only three (2%) samples and one (1%) sample in the RDT positive subgroup, respectively. No parasites lacking the pfhrp2/3 genes were found in the RDT negative subgroup. Conclusion. Plasmodium falciparum histidine-rich protein 2/3 gene deletions are uncommon in the surveyed population, and do not result in diagnostic failure. We encourage the use of rigorous PCR methods to identify pfhrp2/3 gene deletions in order to minimize the overestimation of their prevalence.
A qualitative study on Patient-Centered Care and Perception of Nurses in Primary Healthcare Practice
Authors: Lateef Adepeju , Mhlongo Euphemia Mbali
Published: November 2021

Background: Patient-centered care (PCC) approach has continued to gain recognition globally as the key to providing quality healthcare. However, this concept is not fully integrated into the management of primary health care (PHC) in existing nursing practice due to numerous challenges. Among these challenges is the perception of nursing on PCC in the Primary Health Care system. This study seeks to present the results of qualitative research performed at various selected PHC centres on nurses’ perceptions in PCC practice. This study aim was to explore the perception of nurses on PCC. A qualitative action research approach was adopted. Methods: This study involved 30 local government PHC centres located in Osun State Southwest of the federal republic of Nigeria. Data was collected through a semi-structured interview. Thereafter, data analysis was performed using thematic analysis and NVivo 12 software to generate themes, subthemes, and codes. Results: PCC perceptions of nurses that was revealed in our findings were categorised into positive and negative themes. The negative themes include: Poor approach by the nurses and lack of enforcement agency. The positive themes that emerged include: outcome driven healthcare, valued care provider, communication to sharpen care and driven healthcare service. Conclusion: There is need for continuous training, and upgrading of nurses in line with global recommended standards of providing quality healthcare service delivery to the people. Therefore, the federal and state governments and local government council through the Nursing Council body should regulate, supervise, monitor and enforce the use and implementation of PCC in the PHC healthcare system.