Relation of Lipoprotein(a) Levels to Incident Type 2 Diabetes and Modification by Alirocumab Treatment
Authors: Schwartz Gregory G. , Szarek Michael , Bittner Vera A. , Bhatt Deepak L. , Diaz Rafael , Goodman Shaun G. , Jukema J. Wouter , Loy Megan , Manvelian Garen , Pordy Robert , White Harvey D. , Steg Philippe Gabriel ,   ODYSSEY OUTCOMES Committees and Investigators, Schwartz Gregory G. , Steg Philippe Gabriel , Bhatt Deepak L. , Bittner Vera A. , Diaz Rafael , Goodman Shaun G. , Harrington Robert A. , Jukema J. Wouter , Szarek Michael , White Harvey D. , Zeiher Andreas M. , Tricoci Pierluigi , Roe Matthew T. , Mahaffey Kenneth W. , Edelberg Jay M. , Hanotin Corinne , Lecorps Guillaume , Moryusef Angèle , Pordy Robert , Sasiela William J. , Tamby Jean-François , Aylward Philip E. , Drexel Heinz , Sinnaeve Peter , Dilic Mirza , Lopes Renato D. , Gotcheva Nina N. , Prieto Juan-Carlos , Yong Huo , López-Jaramillo Patricio , Pećin Ivan , Reiner Zeljko , Ostadal Petr , Viigimaa Margus , Nieminen Markku S. , Chumburidze Vakhtang , Marx Nikolaus , Danchin Nicolas , Liberopoulos Evangelos , Montenegro Valdovinos Pablo Carlos , Tse Hung-Fat , Kiss Robert Gabor , Xavier Denis , Zahger Doron , Valgimigli Marco , Kimura Takeshi , Kim Hyo Soo , Kim Sang-Hyun , Erglis Andrejs , Laucevicius Aleksandras , Kedev Sasko , Yusoff Khalid , Ramos López Gabriel Arturo , Alings Marco , Halvorsen Sigrun , Correa Flores Roger M. , Budaj Andrzej , Morais Joao , Dorobantu Maria , Karpov Yuri , Ristic Arsen D. , Chua Terrance , Murin Jan , Fras Zlatko , Dalby Anthony J. , Tuñón José , de Silva H. Asita , Hagström Emil , Landmesser Ulf , Chiang Chern-En , Sritara Piyamitr , Guneri Sema , Parkhomenko Alexander , Ray Kausik K. , Moriarty Patrick M. , Vogel Robert , Chaitman Bernard , Kelsey Sheryl F. , Olsson Anders G. , Rouleau Jean-Lucien , Simoons Maarten L. , Alexander Karen , Meloni Chiara , Rosenson Robert , Sijbrands Eric J.G. , Tricoci Pierluigi , Alexander John H. , Armaganijan Luciana , Bagai Akshay , Bahit Maria Cecilia , Brennan J. Matthew , Clifton Shaun , DeVore Adam D. , Deloatch Shalonda , Dickey Sheila , Dombrowski Keith , Ducrocq Grégory , Eapen Zubin , Endsley Patricia , Eppinger Arleen , Harrison Robert W. , Hess Connie Ng , Hlatky Mark A. , Jordan Joseph Dedrick , Knowles Joshua W. , Kolls Bradley J. , Kong David F. , Leonardi Sergio , Lillis Linda , Maron David J. , Marcus Jill , Mathews Robin , Mehta Rajendra H. , Mentz Robert J. , Moreira Humberto Graner , Patel Chetan B. , Bernardez-Pereira Sabrina , Perkins Lynn , Povsic Thomas J. , Puymirat Etienne , Schuyler Jones William , Shah Bimal R. , Sherwood Matthew W. , Stringfellow Kenya , Sujjavanich Darin , Toma Mustafa , Trotter Charlene , Van Diepen Sean , Wilson Matthew D. , Yan Andrew T. , Schiavi Lilia B. , Garrido Marcelo , Alvarisqueta Andrés F. , Sassone Sonia A. , Bordonava Anselmo P. , Alves De Lima Alberto E. , Schmidberg Jorge M. , Duronto Ernesto A. , Caruso Orlando C. , Novaretto Leonardo P. , Hominal Miguel Angel , Montaña Oscar R. , Caccavo Alberto , Gomez Vilamajo Oscar A. , Lorenzatti Alberto J. , Cartasegna Luis R. , Paterlini Gustavo A. , Mackinnon Ignacio J. , Caime Guillermo D. , Amuchastegui Marcos , Salomone Oscar , Codutti Oscar R. , Jure Horacio O. , Bono Julio O.E. , Hrabar Adrian D. , Vallejos Julio A. , Ahuad Guerrero Rodolfo A. , Novoa Federico , Patocchi Cristian A. , Zaidman Cesar J. , Giuliano Maria E. , Dran Ricardo D. , Vico Marisa L. , Carnero Gabriela S. , Guzman Pablo N. , Medrano Allende Juan C. , Garcia Brasca Daniela F. , Bustamante Labarta Miguel H. , Nani Sebastian , Blumberg Eduardo D.S. , Colombo Hugo R. , Liberman Alberto , Fuentealba Victorino , Luciardi Hector L. , Waisman Gabriel D. , Berli Mario A. , Garcia Duran Ruben O. , Cestari Horacio G. , Luquez Hugo A. , Giordano Jorge A. , Saavedra Silvia S. , Zapata Gerardo , Costamagna Osvaldo , Llois Susana , Waites Jonathon H. , Collins Nicholas , Soward Allan , Hii Chris L.S. , Shaw James , Arstall Margaret A. , Horowitz John , Ninio Daniel , Rogers James F. , Colquhoun David , Oqueli Flores Romulo E. , Roberts-Thomson Philip , Raffel Owen , Lehman Sam J. , Aroney Constantine , Coverdale Steven G.M. , Garrahy Paul J. , Starmer Gregory , Sader Mark , Carroll Patrick A. , Dick Ronald , Zweiker Robert , Hoppe Uta , Huber Kurt , Berger Rudolf , Delle-Karth Georg , Frey Bernhard , Weidinger Franz , Faes Dirk , Hermans Kurt , Pirenne Bruno , Leone Attilio , Hoffer Etienne , Vrolix Mathias C.M. , De Wolf Luc , Wollaert Bart , Castadot Marc , Dujardin Karl , Beauloye Christophe , Vervoort Geert , Striekwold Harry , Convens Carl , Roosen John , Barbato Emanuele , Claeys Marc , Cools Frank , Terzic Ibrahim , Barakovic Fahir , Midzic Zlatko , Pojskic Belma , Fazlibegovic Emir , Kulić Mehmed , Durak-Nalbantic Azra , Vulic Dusko , Muslibegovic Adis , Goronja Boris , Reis Gilmar , Sousa Luciano , Nicolau Jose C. , Giorgeto Flavio E. , Silva Ricardo P. , Nigro Maia Lilia , Rech Rafael , Rossi Paulo R.F. , Cerqueira Maria José A.G. , Duda Norberto , Kalil Renato , Kormann Adrian , Abrantes José Antonio M. , Pimentel Filho Pedro , Soggia Ana Priscila , de Santos Mayler O.N. , Neuenschwander Fernando , Bodanese Luiz C. , Michalaros Yorghos L. , Eliaschewitz Freddy G. , Vidotti Maria H. , Leaes Paulo E. , Botelho Roberto V. , Kaiser Sergio , Manenti Euler Roberto Fernandes , Precoma Dalton B. , Moura Jorge Jose C. , Silva Pedro G. , Silveira Jose A. , Saporito Wladmir , Marin-Neto Jose A. , Feitosa Gilson S. , Ritt Luiz Eduardo F. , de Souza Juliana A. , Costa Fernando , Souza Weimar K.S.B. , Reis Helder J.L. , Machado Leandro , Ayoub José Carlos Aidar , Todorov Georgi V. , Nikolov Fedya P. , Velcheva Elena S. , Tzekova Maria L. , Benov Haralambi O. , Petranov Stanislav L. , Tumbev Haralin S. , Shehova-Yankova Nina S. , Markov Dimitar T. , Raev Dimitar H. , Mollov Mihail N. , Kichukov Kostadin N. , Ilieva-Pandeva Katya A. , Ivanova Raya , Gospodinov Maryana , Mincheva Valentina M. , Lazov Petar V. , Dimov Bojidar I. , Senaratne Manohara , Stone James , Kornder Jan , Pearce Stephen , Dion Danielle , Savard Daniel , Pesant Yves , Pandey Amritanshu , Robinson Simon , Gosselin Gilbert , Vizel Saul , Hoag Gordon , Bourgeois Ronald , Morisset Anne , Sabbah Eric , Sussex Bruce , Kouz Simon , MacDonald Paul , Diaz Ariel , Michaud Nicolas , Fell David , Leung Raymond , Vuurmans Tycho , Lai Christopher , Nigro Frank , Davies Richard , Nogareda Gustavo , Vijayaraghavan Ram , Ducas John , Lepage Serge , Mehta Shamir , Cha James , Dupuis Robert , Fong Peter , Lutchmedial Sohrab , Rodes-Cabau Josep , Fadlallah Hussein , Cleveland David , Huynh Thao , Bata Iqbal , Hameed Adnan , Pincetti Cristian , Potthoff Sergio , Acevedo Monica , Aguirre Arnoldo , Vejar Margarita , Yañez Mario , Araneda Guillermo , Fernandez Mauricio , Perez Luis , Varleta Paola , Florenzano Fernando , Huidobro Laura , Raffo Carlos A. , Olivares Claudia , Nahuelpan Leonardo , Montecinos Humberto , Chen Jiyan , Dong Yugang , Huang Weijian , Wang Jianzhong , Huang Shi'An , Yao Zhuhua , Li Xiang , Cui Lan , Lin Wenhua , Sun Yuemin , Wang Jingfeng , Li Jianping , Zhang Xuelian , Zhu Hong , Chen Dandan , Huang Lan , Dong Shaohong , Su Guohai , Xu Biao , Su Xi , Cheng Xiaoshu , Lin Jinxiu , Zong Wenxia , Li Huanming , Feng Yi , Xu Dingli , Yang Xinchun , Ke Yuannan , Lin Xuefeng , Zhang Zheng , Zheng Zeqi , Luo Zhurong , Chen Yundai , Ding Chunhua , Zhong Yi , Zheng Yang , Li Xiaodong , Peng Daoquan , Zhao Shuiping , Li Ying , Liu Xuebo , Wei Meng , Liu Shaowen , Yu Yihua , Qu Baiming , Jiang Weihong , Zhou Yujie , Zhao Xingsheng , Yuan Zuyi , Guo Ying , Xu Xiping , Shi Xubo , Ge Junbo , Fu Guosheng , Bai Feng , Fang Weiyi , Shou Xiling , Yang Xiangjun , Wang Jian’An , Xiang Meixiang , Sun Yingxian , Lu Qinghua , Zhang Ruiyan , Zhu Jianhua , Xu Yizhou , Fan Zhongcai , Li Tianchang , Wu Chun , Jaramillo Nicolas , Sanchez Vallejo Gregorio , Luna Botia Diana C. , Botero Lopez Rodrigo , Molina De Salazar Dora I. , Cadena Bonfanti Alberto J. , Cotes Aroca Carlos , Diego Higuera Juan , Blanquicett Marco , Barrera Silva Sandra I. , Garcia Lozada Henry J. , Coronel Arroyo Julian A. , Accini Mendoza Jose L. , Fernandez Ruiz Ricardo L. , Quintero Ossa Alvaro M. , Manzur Jatin Fernando G. , Sotomayor Herazo Aristides , Castellanos Parada Jeffrey , Suarez Arambula Rafael , Urina Triana Miguel A. , Fernandez Trujillo Angela M. , Strozzi Maja , Car Siniša , Jerić Melita , Miličić Davor , Benčić Martina Lovrić , Pintarić Hrvoje , Prvulović Đeiti , Šikić Jozica , Peršić Viktor , Mileta Dean , Štambuk Kresimir , Babić Zdravko , Tomulic Vjekoslav , Lukenda Josip , Mejic-Krstulovic Stanka , Starcevic Boris , Spinar Jindrich , Horak David , Velicka Zdenek , Stasek Josef , Alan David , Machova Vilma , Linhart Ales , Novotny Vojtech , Kaucak Vladimir , Rokyta Richard , Naplava Robert , Coufal Zdenek , Adamkova Vera , Podpera Ivo , Zizka Jiri , Motovska Zuzana , Marusincova Ivana , Svab Premysl , Heinc Petr , Kuchar Jiri , Povolny Petr , Matuska Jiri , Poulsen Steen H. , Raungaard Bent , Clemmensen Peter , Bang Lia E. , May Ole , Bøttcher Morten , Hove Jens D. , Frost Lars , Gislason Gunnar , Larsen John , Betton Johansen Peter , Hald Flemming , Johansen Peter , Jeppesen Jørgen , Nielsen Tonny , Kristensen Kjeld S. , Walichiewicz Piotr Maria , Lomholdt Jens D. , Klausen Ib C. , Nielsen Peter Kaiser , Davidsen Flemming , Videbaek Lars , Soots Mai , Vahula Veiko , Hedman Anu , Soopõld Üllar , Märtsin Kaja , Jurgenson Tiina , Kristjan Arved , Airaksinen Juhani K. , Vikman Saila , Huikuri Heikki , Coste Pierre , Ferrari Emile , Morel Olivier , Montalescot Gilles , Machecourt Jacques , Barone-Rochette Gilles , Mansourati Jacques , Cottin Yves , Leclercq Florence , Belhassane Abdelkader , Delarche Nicolas , Boccara Franck , Paganelli Franck , Clerc Jérôme , Schiele Francois , Aboyans Victor , Probst Vincent , Berland Jacques , Lefèvre Thierry , Citron Bernard , Khintibidze Irakli , Shaburishvili Tamaz , Pagava Zurab , Ghlonti Ramaz , Lominadze Zaza , Khabeishvili George , Hemetsberger Rayyan , Edward Kemala , Rauch-Kröhnert Ursula , Stratmann Matthias , Appel Karl-Friedrich , Schmidt Ekkehard , Omran Heyder , Stellbrink Christoph , Dorsel Thomas , Lianopoulos Emmanouil , Vöhringer Hans Friedrich , Marx Roger , Zirlik Andreas , Schellenberg Detlev , Heitzer Thomas , Laufs Ulrich , Werner Christian , Marx Nikolaus , Gielen Stephan , Nuding Sebastian , Winkelmann Bernhard , Behrens Steffen , Sydow Karsten , Karakas Mahir , Simonis Gregor , Muenzel Thomas , Werner Nikos , Leggewie Stefan , Böcker Dirk , Braun-Dullaeus Rüdiger , Toursarkissian Nicole , Jeserich Michael , Weißbrodt Matthias , Schaeufele Tim , Weil Joachim , Völler Heinz , Waltenberger Johannes , Natour Mohammed , Schmitt Susanne , Müller-Wieland Dirk , Steiner Stephan , Heidenreich Lothar , Offers Elmar , Gremmler Uwe , Killat Holger , Rieker Werner , Patsilinakos Sotiris , Kartalis Athanasios , Manolis Athanassios , Sionis Dimitrios , Chachalis Geargios , Skoumas Ioannis , Athyros Vasilios , Vardas Panagiotis , Parthenakis Frangkiskos , Alexopoulos Dimitrios , Hahalis Georgios , Lekakis John , Hatzitolios Apostolos , Fausto Ovando Sergio R. , Arango Benecke Juan L. , Rodriguez De Leon Edgar R. , Yan Bryan P.Y. , Siu David C.W. , Turi Tibor , Merkely Bela , Ungi Imre , Lupkovics Geza , Nagy Lajos , Katona András , Édes István , Müller Gábor , Horvath Iván , Kapin Tibor , Szigeti Zsolt , Faluközy József , Kumbla Mukund , Sandhu Manjinder , Annam Sharath , Proddutur Naveen Reddy , Regella Reddy , Premchand Rajendra K. , Mahajan Ajaykumar , Pawar Sudhir , Abhyanakar Atul D. , Kerkar Prafulla , Govinda Ravishankar A. , Oomman Abraham , Sinha Dhurjati , Patil Sachin N. , Kahali Dhiman , Sawhney Jitendra , Joshi Abhijeet B. , Chaudhary Sanjeev , Harkut Pankaj , Guha Santanu , Porwal Sanjay , Jujjuru Srimannarayana , Pothineni Ramesh B. , Monteiro Minguel R. , Khan Aziz , Iyengar Shamanna S. , Grewal Jasprakash Singh , Chopda Manoj , Fulwani Mahesh C. , Patange Aparna , Sachin Patil , Chopra Vijay K. , Goyal Naresh K. , Shinde Rituparna , Manakshe Gajendra V. , Patki Nitin , Sethi Sumeet , Munusamy Vengatesh , Karna Sunil , Thanvi Sunil , Adhyapak Srilakshmi , Patil Chandrakant , Pandurangi Ulhas , Mathur Rishabh , Gupta Jugal , Kalashetti Suhas , Bhagwat Ajit , Raghuraman Bagirath , Yerra Shiv Kumar , Bhansali Prasant , Borse Rohidas , Rahul Patil , Das Srihari , Kumar Vinay , Abdullakutty Jabir , Saathe Shireesh , Palimkar Priya , Sathe Shireesh , Atar Shaul , Shechter Michael , Mosseri Morris , Arbel Yaron , Ehud Chorin , Ofer Havakuk , Lotan Chaim , Rosenschein Uri , Katz Amos , Henkin Yaakov , Francis Adi , Klutstein Marc , Nikolsky Eugenia , Zukermann Robert , Turgeman Yoav , Halabi Majdi , Marmor Alon , Kornowski Ran , Jonas Michael , Amir Offer , Hasin Yonathan , Rozenman Yoseph , Fuchs Shmuel , Zvi Vered , Hussein Osamah , Gavish Dov , Vered Zvi , Caraco Yoseph , Elias Mazen , Tov Naveh , Wolfovitz Efrat , Lishner Michael , Elias Nizar , Piovaccari Giancarlo , De Pellegrin Annamaria , Garbelotto Raffaella , Guardigli Gabriele , Marco Valgimigli , Licciardello Giovanni , Auguadro Carla , Scalise Filippo , Cuccia Claudio , Salvioni Alessandro , Musumeci Giuseppe , Senni Michelle , Calabrò Paolo , Novo Salvatore , Faggiano Pompilio , Metra Marco , De Cesare Nicoletta B. , Berti Sergio , Cavallini Claudio , Puccioni Enrico , Galvani Marcello , Tespili Maurizio , Piatti Piermarco , Palvarini Michela , De Luca Giuseppe , Violini Roberto , De Leo Alessandro , Olivari Zoran , Perrone Filardi Pasquale , Ferratini Maurizio , Racca Vittorio , Dai Kazuoki , Shimatani Yuji , Kamiya Haruo , Ando Kenji , Takeda Yoshihiro , Morino Yoshihiro , Hata Yoshiki , Kimura Kazuo , Kishi Koichi , Michishita Ichiro , Uehara Hiroki , Higashikata Toshinori , Hirayama Atsushi , Hirooka Keiji , Doi Yasuji , Sakagami Satoru , Taguchi Shuichi , Koike Akihiro , Fujinaga Hiroyuki , Koba Shinji , Kozuma Ken , Kawasaki Tomohiro , Ono Yujiro , Shimizu Masatoshi , Katsuda Yousuke , Wada Atsuyuki , Shinke Toshiro , Kimura Takeshi , Ako Junya , Fujii Kenshi , Takahashi Toshiyuki , Sakamoto Tomohiro , Nakao Koichi , Furukawa Yutaka , Sugino Hiroshi , Tamura Ritsu , Mano Toshiaki , Uematsu Masaaki , Utsu Noriaki , Ito Kashima , Haraguchi Takuya , Sato Katsuhiko , Ueda Yasunori , Nishibe Akira , Fujimoto Kazuteru , Masutani Motomaru , Yoon Jung Han , Kim Hack-Lyoung , Park Hun Sik , Chae In-Ho , Kim Moo Hyun , Jeong Myung Ho , Rha Seungwoon , Kim Chongjin , Kim Hyo-Soo , Kim Hae Young , Hong Taekjong , Tahk Seung-Jea , Kim Youngkwon , Busmane Arija , Pontaga Natalija , Strelnieks Aldis , Mintale Iveta , Sime Iveta , Petrulioniene Zaneta , Kavaliauskiene Roma , Jurgaitiene Ruta , Sakalyte Gintare , Slapikas Rimvydas , Norkiene Sigute , Misonis Nerijus , Kibarskis Aleksandras , Kubilius Raimondas , Bojovski Stojko , Lozance Nensi , Kjovkaroski Aleksandar , Doncovska Snezana , Ong Tiong Kiam , Kasim Sazzli , Maskon Oteh , Kandasamy Balachandran , Liew Houng B. , Wan Mohamed Wan Mohd Izani , García Castillo Armando , Carrillo Calvillo Jorge , Fajardo Campos Pedro , Núñez Fragoso Juan Carlos , Bayram Llamas Edmundo Alfredo , Alcocer Gamba Marco Antonio , Carranza Madrigal Jaime , González Salas Luis Gerardo , López Rosas Enrique , González Díaz Belinda , Salcido Vázquez Eduardo , Nacoud Ackar Alfredo , Llamas Esperón Guillermo Antonio , Martínez Sánchez Carlos Rodolfo , Guerrero De Leon María , Suarez Otero Rodrigo , Fanghänel Salmón Guillermo , Pérez Ríos Jesús Antonio , Garza Ruíz José Angel , Breedveld Robert W. , Feenema-Aardema Margriet , Borger-Van Der Burg Alida , Hoogslag Pieter A.M. , Suryapranata Harry , Oomen Antonius , Van Haelst Paulus , Wiersma Jacobijne J. , Basart Dirk , Van Der Wal Ruud M.A. , Zwart Peter , Monraats Pascalle , Van Kesteren Henricus , Karalis Ioannis , Jukema Johan , Verdel Gerardus J.E. , Brueren Bart R.G. , Troquay Roland P.T. , Viergever Eric P. , Al-Windy Nadea Y.Y. , Bartels Gerard L. , Cornel Jan H. , Hermans Walter R.M. , Herrman Johannes P.R. , Bos Robert J. , Groutars Reginald G.E.J. , Van Der Zwaan Coenraad C. , Kaplan Refik , Lionarons Raymond , Ronner Eelko , Groenemeijer Bjorn E. , Bronzwaer Patrick N.A. , Liem Anho A.H. , Rensing Bernard J.W.M. , Bokern Marcel J.J.A. , Nijmeijer Remco , Hersbach Ferry M.R.J. , Willems Frank F. , Gosselink Antonius T.M. , Rasoul Saman , Elliott John , Wilkins Gerard , Fisher Raewyn , Scott Douglas , Hart Hamish , Stewart Ralph , Harding Scott , Ternouth Ian , Fisher Nicholas , Wilson Samuel , Aitken Denise , Anscombe Russell , Davidson Laura , Tomala Tadeusz , Nygård Ottar , Sparby Jon Arne , Andersen Kjell , Gullestad Lars , Jortveit Jarle , Munk Peter S. , Singsaas Erlend gyllensten , Hurtig Ulf , Calderon Ticona Jorge R. , Durand Velasquez Julio R. , Negron Miguel Sandra A. , Sanabria Perez Enrique S. , Carrion Chambilla Jesus M. , Chavez Ayala Carlos A. , Castillo Leon Reynaldo P. , Vargas Gonzales Rolando J. , Hernandez Zuniga Jose D. , Camacho Cosavalente Luis A. , Bravo Mannucci Jorge E. , Heredia Landeo Javier , Llerena Navarro Nassip C. , Roldan Concha Yudy M. , Rodriguez Chavez Víctor E. , Anchante Hernandez Henry A. , Zea Nunez Carlos A. , Mogrovejo Ramos Walter , Ferrolino Arthur , Sy Rosa Allyn G. , Tirador Louie , Sy Rody G. , Matiga Generoso , Coching Raul Martin , Bernan Alisa , Rogelio Gregorio , Morales Dante D. , Tan Edgar , Sulit Dennis Jose , Wlodarczak Adrian , Jaworska Krystyna , Skonieczny Grzegorz , Pawlowicz Lidia , Wojewoda Pawel , Busz-Papiez Benita , Bednarski Janusz , Goch Aleksander , Staneta Pawel , Dulak Elzbieta , Saminski Krzysztof , Krasowski Wlodzimierz , Sudnik Wanda , Zurakowski Aleksander , Skorski Marcin , Miklaszewicz Beata , Kubica Jacek , Andrzej Lipko Jan , Kostarska-Srokosz Edyta , Piepiorka Marek , Drzewiecka Anna , Sciborski Ryszard , Stasiewski Arkadiusz , Blicharski Tomasz , Bystryk Leszek , Szpajer Michal , Korol Marek , Czerski Tomasz , Mirek-Bryniarska Ewa , Gniot Jacek , Lubinski Andrzej , Gorny Jerzy , Franek Edward , Raczak Grzegorz , Szwed Hanna , Monteiro Pedro , Mesquita Bastos Jose , Pereira Helder H. , Martins Dinis , Seixo Filipe , Mendonça Carlos , Botelho Ana , Caetano Francisca , Minescu Bogdan , Istratoaie Octavian , Tesloianu Dan N. , Cristian Gabriel , Dumitrescu Silviu , Podoleanu Cristian G.C. , Constantinescu Mircea C.A. , Bengus Cristina M. , Militaru Constantin , Rosu Doina , Parepa Irinel R. , Matei Adrian V. , Alexandru Tom M. , Malis Mihaela , Coman Ioan , Stanescu-Cioranu Rodica , Dimulescu Doina , Shvarts Yury , Orlikova Olga , Kobalava Zhanna , Barbarash Olga L. , Markov Valentin , Lyamina Nadezhda , Gordienko Alexander , Zrazhevsky Konstantin , Vishnevsky Alexander Y. , Gurevich Victor , Stryuk Raisa , Lomakin Nikita V. , Bokarev Igor , Khlevchuk Tatiana , Shalaev Sergey , Khaisheva Larisa , Chizhov Petr , Viktorova Inna , Osokina Natalya , Shchekotov Vladimir , Akatova Evgenia , Chumakova Galina , Libov Igor , Voevoda Mikhail I. , Tretyakova Tatyana V. , Baranov Evgeny , Shustov Sergey , Yakushin Sergey , Gordeev Ivan , Khasanov Niiaz , Reshetko Olga , Sotnikova Tatiana , Molchanova Olga , Nikolaev Konstantin , Gapon Liudmila , Baranova Elena , Shogenov Zaur , Kosmachova Elena , Karpov Yuriy , Povzun Anton , Egorova Liudmila , Tyrenko Vadim V. , Ivanov Igor G. , Ilya Masterov , Kanorsky Sergey , Simic Dragan , Ivanovic Nikola , Davidovic Goran , Tasic Nebojsa , Asanin Milika R. , Stojic Stevo , Apostolovic Svetlana R. , Ilic Stevan , Putnikovic Tosic Biljana , Stankovic Aleksandar , Arandjelovic Aleksandra , Radovanovic Slavica , Todic Branislava , Balinovac Jovan , Dincic Dragan V. , Seferovic Petar , Karadzic Ana , Dodic Slobodan , Dimkovic Sinisa , Jakimov Tamara , Poh Kian-Keong , Ong Hean Yee , Tang I-Shing Justin , Micko Karol , Nociar Jan , Pella Daniel , Fulop Peter , Hranai Marian , Palka Juraj , Mazur Juraj , Majercák Ivan , Dzupina Andrej , Fazekas František , Gonsorcik Jozef , Bugan Viliam , Selecky Juraj , Kamensky Gabriel , Strbova Jaroslava , Smik Rudolf , Dukat Andrej , Olexa Peter , Žuran Ivan , Poklukar Janez , Černič Šuligoj Nataša , Cevc Matija , Cyster Henry P. , Ranjith Naresh , Corbett Clive , Bayat Junaid , Makotoko Ellen Makoali , du Toit Theron Hendrik , Kapp Ilse E. , de V. Basson Matthys M. , Lottering Hanlie , Van Aswegen Dina , Van Zyl Louis J. , Sebastian Peter J. , Pillay Thayabran , Saaiman Jan A. , Commerford Patrick J. , Cassimjee Soraya , Riaz Garda , Ebrahim Iftikhar O. , Sarvan Mahomed , Mynhardt Joseph H. , Reuter Helmuth , Moodley Rajendran , Vida Manuel , Cequier Fillat Angel R. , Bodí Peris Vicente , Fuentes Jimenez Francisco , Marín Francisco , Cruz Fernández Jose M. , Hidalgo Urbano Rafael Jesus , Gil-Extremera Blas , Toledo Pablo , Worner Diz Fernando , Garcia-Dorado David , Iñiguez Andres , Tuñón Fernández José , Gonzalez-Juanatey Jose R. , Fernandez Portales Javier , Civeira Murillo Fernando , Matas Pericas Laia , Zamorano Jose Luis , De Mora Martin Manuel , Bruguera Cortada Jordi , Alonso Martin Joaquin J. , Serrano Antolin Jose Maria , De Berrazueta Fernández José R. , Vázquez de Prada José Antonio , Díaz Fernández Jose Francisco , García Lledó José Alberto , Cosín Sales Juan , Botas Rodriguez Javier , Gusi Tragant Gabriel , Benedicto Amparo , Gonzalez-Juanatey Carlos , Camprubí Potau Mercedes , Plaza Perez Ignacio , De La Tassa César Morís , Loma-Osorio Rincon Pablo , Balaguer Recena Javier , Escudier Juan M. , Coca Payeras Antonio , Alonso Orcajo Norberto , Valdivielso Pedro , Constantine Godwin , Haniffa Ruvaiz , Tissera Nirmali , Amarasekera Stanley , Ponnamperuma Chandrike , Fernando Nimali , Fernando Kaputella , Jayawardena Jayanthimala , Wijeyasingam Santharaj , Ranasinghe Gotabhaya , Ekanayaka Ruvan , Mendis Sepalika , Senaratne Vajira , Mayurathan Gnanamoorthy , Sirisena Thilak , Rajapaksha Ajantha , Herath Jagath I. , Amarasena Naomali , Berglund Stefan , Rasmanis Gundars , Vedin Ola , Witt Nils , Mourtzinis Georgios , Nicol Peter , Hansen Ole , Romeo Stefano , Agergaard Jensen Steen , Torstensson Ingemar , Ahremark Ulf , Sundelin Torbjörn , Moccetti Tiziano , Müller Christian , Mach Francois , Binde Ronald , Gämperli Oliver , Tsai Wei-Chuan , Ueng Kwo-Chang , Lai Wen-Ter , Liu Ming-En , Hwang Juey-Jen , Yin Wei-Hsian , Hsieh I-Chang , Hsieh Ming-Jer , Lin Wei Hsiang , Kuo Jen-Yuan , Huang Tsuei-Yuan , Fang Chih-Yuan , Kaewsuwanna Pinij , Soonfuang Wasant , Jintapakorn Woravut , Sukonthasarn Apichard , Wongpraparut Nattawut , Sastravaha Krisada , Sansanayudh Nakarin , Kehasukcharoen Wirash , Piyayotai Dilok , Chotnoparatpat Paiboon , Camsari Ahmet , Kultursay Hakan , Mutlu Bulent , Ersanli Murat , Demirtas Mustafa , Kirma Cevat , Ural Ertan , Koldas Lale , Karpenko Oleksandr , Prokhorov Alexander , Vakaluyk Ihor , Myshanych Halyna , Reshotko Dmytro , Batushkin Valeriy , Rudenko Leonid , Kovalskyi Ihor , Kushnir Mykola , Tseluyko Vira , Mostovoy Yuriy , Stanislavchuk Mykola , Kyiak Yulian , Karpenko Yuriy , Malynovsky Yaroslav , Klantsa Andriy , Kutniy Oles , Amosova Ekaterina , Tashchuk Viktor , Leshchuk Oleh , Rishko Mykola , Kopytsya Mykola , Yagensky Andriy , Vatutin Mykola , Bagriy Andriy , Barna Olga M. , Ushakov Olexiy , Dzyak Georgiy , Goloborodko Borys , Rudenko Anatolii , Zheleznyy Volodymyr , Trevelyan Jasper , Zaman Azfar , Lee Kaeng , Moriarty Andrew , Aggarwal Rajesh K. , Clifford Piers , Wong Yuk-Ki , Iqbal Syed M.R. , Subkovas Eduardas , Braganza Denise , Sarkar David , Storey Robert , Griffiths Huw , McClure Sam , Muthusamy Rangasamy , Smith Simon , Kurian John , Levy Terry , Barr Craig , Kadr Honer , Gerber Robert , Simaitis Audrius , Soran Handrean , Mathur Anthony , Brodison Adrian , Ayaz Mohammad , Cheema Muhammad , Oliver Richard , Thackray Simon , Mudawi Telal , Rahman Gohar , Sultan Ayyaz , Reynolds Timothy , Sharman David , Sprigings David , Butler Rob , Wilkinson Peter , Lip Gregory Y.H. , Halcox Julian , Gallagher Sean , Ossei-Gerning Nicholas , Vardi Gil , Baldari Duccio , Brabham David , Treasure II Charles , Dahl Charles , Palmer Bruce , Wiseman Alan , Khan Abul , Puri Sanjeev , Elizabeth Mohart Ann , Ince Carlos , Flores Enrique , Wright Scott , Cheng Shi-Chi , Rosenberg Michael , Rogers William , Kosinski Edward , Forgosh Les , Waltman Jonathan , Khan Misal , Shoukfeh Mohammad , Dagher Georges , Cambier Patrick , Lieber Ira , Kumar Priya , East Cara , Krichmar Perry , Hasan Mian , White Lindsey , Knickelbine Thomas , Haldis Thomas , Gillespie Eve , Amidon Thomas , Suh David , Arif Imran , Abdallah Mouhamad , Akhter Faiq , Carlson Eric , D'Urso Michael , El-Ahdab Fadi , Nelson William , Moriarty Katie , Harris Barry , Cohen Steven , Carter Luther , Doty Daniel , Sabatino Kenneth , Haddad Tariq , Malik Amir , Rao Sunder , Mulkay Angel , Jovin Ion , Klancke Kim , Malhotra Vinay , Devarapalli Sai K. , Koren Michael , Chandna Harish , Dodds George , Goraya Tauqir , Bengston James , Janik Matthew , Moran Joseph , Sumner Andrew , Kobayashi John , Davis William , Yazdani Shahram , Pasquini John , Thakkar Maitreya , Vedere Amarnath , Leimbach Wayne , Rider James , Fenton Sarah , Singh Narendra , Shah Anil V. , Janosik Denise , Pepine Carl , Berman Brett , Gelormini Joseph , Daniels Christopher , Richard Kerensky , Keating Friederike , Kondo Nicholas I. , Shetty Sanjay , Levite Howard , Waider Winfried , Takata Theodore , Abu-Fadel Mazen , Shah Vipul , Aggarwal Rahul , Izzo Mark , Kumar Anil , Hattler Brack , Do Rose , Link Chad , Bortnick Anna , Kinzfogl George , Ghitis Arnold , Larry John , Teufel Edward , Kuhlman Peter , Mclaurin Brent , Zhang Wenwu , Thew Stephen , Abbas Jalal , White Matthew , Islam Othman , Subherwal Sumeet , Ranadive Nandkishore , Vakili Babak , Gring Christian , Henderson David , Schuchard Timothy , Farhat Naim , Kline Geoffrey , Mahal Sharan , Whitaker Jack , Speirs Shawn , Andersen Rolf , Daboul Nizar , Horwitz Phillip , Zahr Firas , Ponce George , Jafar Zubair , Mcgarvey Joseph , Panchal Vipul , Voyce Stephen , Blok Thomas , Sheldon William , Azizad Masoud M. , Schmalfuss Carsten , Picone Mark , Pederson Robert , Herzog William , Friedman Keith , Lindsey Jason , Nowins Rosemary , Timothy Eichenlaub , Leonard Parilak , Lepor Norman , El Shahawy Mahfouz , Weintraub Howard , Irimpen Anand , Alonso Alvaro , May Wade , Christopher Daniels , Galski Thomas , Chu Alan , Mody Freny , Ramin Ebrahimi , Hodes Zachary , Rossi Joseph , Rose Gregory , Fairlamb James , Lambert Charles , Raisinghani Ajit , Abbate Antonio , Vetrovec George , King Marilyn , Carey Charles , Gerber Jaime , Younis Liwa , Park Hyeun (Tom) , Vidovich Mladen , Knutson Thomas , Friedman Dennis , Chaleff Fred , Loussararian Arthur , Rozeman Phillip , Kimmelstiel Carey , Kuvin Jeffrey , Silver Kevin , Foster Malcolm , Tonnessen Glen , Espinoza Andrey , Amlani Mohamadali , Wali Andreas , Malozzi Christopher , Jong Geert T. , Massey Clara , Wattanakit Keattiyoat , O’Donnell Philip J. , Singal Dinesh , Jaffrani Naseem , Banuru Sridhar , Fisher Daniel , Xenakis Mark , Perlmutter Neal , Bhagwat Ravi , Strader James , Blonder Ronald , Akyea-Djamson Ayim , Labroo Ajay , Lee Kwan , Marais H. John , Claxton Edmund , Weiss Robert , Kathryn Rohr , Berk Martin , Rossi Peter , Joshi Parag , Khera Amit , Khaira Ajit S. , Kumkumian Greg , Lupovitch Steven , Purow Joshua , Welka Stephen , Hoffman David , Fischer Stuart , Soroka Eugene , Eagerton Donald , Pancholy Samir , Ray Michael , Erenrich Norman , Farrar Michael , Pollock Stewart , French William J. , Diamantis Steve , Guy Douglas , Gimple Lawrence , Neustel Mark , Schwartz Steven , Pereira Edward , Albert Seals , Spriggs Douglas , Strain Janet , Mittal Suneet , Vo Anthony , Chane Majed , Hall Jason , Vijay Nampalli , Lotun Kapildeo , Lester F. Martin , Nahhas Ahed , Pope Theodore , Nager Paul , Vohra Rakesh , Sharma Mukesh , Bashir Riyaz , Ahmed Hinan , Berlowitz Michael , Fishberg Robert , Barrucco Robert , Yang Eric , Radin Michael , Sporn Daniel , Stapleton Dwight , Eisenberg Steven , Landzberg Joel , Mcgough Martin , Turk Samir , Schwartz Michael , Sundram P. Sandy , Jain Diwakar , Zainea Mark , Bayron Carlos , Karlsberg Ronald , Dohad Suhail , Lui Henry , Keen William , Westerhausen Donald , Khurana Sandeep , Agarwal Himanshu , Birchem Jessica , Penny William , Chang Mark , Murphy Sherrill , Henry John , Schifferdecker Branislav , Gilbert John M. , Chalavarya Gopal , Eaton Charles , Schmedtje John F. , Christenson Stuart , Dotani Imran , Denham Douglas , Macdonell Alexander , Gibson Paul , Rahman Aref , Al Joundi Tammam , Assi Nizar , Conrad Gary , Kotha Purushotham , Love Michael , Giesler Gregory , Rubenstein Howard , Gamil Dawood , Akright Laura , Krawczyk Justine , Cobler Joanne , Wells Terry , Welker James , Foster Robert , Gilmore Richard , Anderson Jay , Jacoby Douglas , Harris Bill , Gardner Geraldine , Dandillaya Ramprasad , Vora Kishor , Kostis John , Hunter John , Laxson David , Ball Eric , Wells Terry , Vora Kishor , Ball Eric , Welker James , Lopes Renato D. , Egydio Flavia , Kawakami Anelise , Oliveira Janaina , Wozniak Julianna , Matthews Alexander , Ratky Caroline , Valiris Janine , Berdan Lisa , Hepditch Anita , Quintero Kirby , Rorick Tyrus , Westbrook Melissa , Pascual Andrea , Rovito Carla , Bezault Madeleine , Drouet Elodie , Simon Tabassome , Alsweiler Caroline , Luyten Anne , Butters Julie , Griffith Liddy , Shaw Michelle , Grunberg Lena , Islam Shahidul , Brégeault Marie-France , Bougon Nathalie , Faustino Douglas , Fontecave Sylvie , Murphy Judith , Verrier Melanie , Agnetti Veronique , Andersen Dorthe , Badreddine Emmy , Bekkouche Mhamed , Bouancheau Cecile , Brigui Imane , Brocklehurst Maddy , Cianciarulo Joseph , Devaul Dawn , Domokos Szilvia , Gache Cecile , Gobillot Caroline , Guillou Severine , Healy Jan , Heath Megan , Jaiwal Gayatri , Javierre Carine , Labeirie Julien , Monier Myriam , Morales Ulises , Mrabti Asmaa , Mthombeni Bicky , Okan Betim , Smith Lucile , Sheller Jennifer , Sopena Sebastien , Pellan Valerie , Benbernou Fadela , Bengrait Nafissa , Lamoureux Maud , Kralova Katarina , Scemama Michel , Bejuit Raphael , Coulange Anthony , Berthou Christelle , Repincay Jérôme , Lorenzato Christelle , Etienne Alexis , Gouet Valerie , Lecorps Guillaume , Loizeau Virginie , Normand Mickael , Ourliac Anne , Rondel Christelle , Adamo Antony , Beltran Pascale , Barraud Pauline , Dubois-Gache Helene , Halle Benjamin , Metwally Lamia , Mourgues Maxime , Sotty Marc , Vincendet Marion , Cotruta Raluca , Chengyue Zhu , Fournie-Lloret Dominique , Morrello Christine , Perthuis Aurelie , Picault Patrick , Zobouyan Isabelle , Colhoun Helen M. , Dempsey Michael A. , McClanahan Mark A. 
Published: March 2021

OBJECTIVE

In observational data, lower levels of lipoprotein(a) have been associated with greater prevalence of type 2 diabetes. Whether pharmacologic lowering of lipoprotein(a) influences incident type 2 diabetes is unknown. We determined the relationship of lipoprotein(a) concentration with incident type 2 diabetes and effects of treatment with alirocumab, a PCSK9 inhibitor.

RESEARCH DESIGN AND METHODS

In the ODYSSEY OUTCOMES trial alirocumab was compared with placebo in patients with acute coronary syndrome. Incident diabetes was determined from laboratory, medication, and adverse event data.

RESULTS

Among 13,480 patients without diabetes at baseline, 1,324 developed type 2 diabetes over a median 2.7 years. Median baseline lipoprotein(a) was 21.9 mg/dL. With placebo, 10 mg/dL lower baseline lipoprotein(a) was associated with hazard ratio 1.04 (95% CI 1.02−1.06, P &lt; 0.001) for incident type 2 diabetes. Alirocumab reduced lipoprotein(a) by a median 23.2% with greater absolute reductions from higher baseline levels and no overall effect on incident type 2 diabetes (hazard ratio 0.95, 95% CI 0.85–1.05). At low baseline lipoprotein(a) levels, alirocumab tended to reduce incident type 2 diabetes, while at high baseline lipoprotein(a) alirocumab tended to increase incident type 2 diabetes compared with placebo (treatment–baseline lipoprotein(a) interaction P = 0.006). In the alirocumab group, a 10 mg/dL decrease in lipoprotein(a) from baseline was associated with hazard ratio 1.07 (95% CI 1.03−1.12; P = 0.0002) for incident type 2 diabetes.

CONCLUSIONS

In patients with acute coronary syndrome, baseline lipoprotein(a) concentration associated inversely with incident type 2 diabetes. Alirocumab had neutral overall effect on incident type 2 diabetes. However, treatment-related reductions in lipoprotein(a), more pronounced from high baseline levels, were associated with increased risk of incident type 2 diabetes. Whether these findings pertain to other therapies that reduce lipoprotein(a) is undetermined.