bluuebunny/crossref_metadata_2025 huggingface dataset:
Atomically Precise Distorted Nanographenes: The Effect of Different Edge Functionalization on the Photophysical Properties down to the Femtosecond Scale
Authors: Reale Marco , Sciortino Alice , Cannas Marco , Maçoas Ermelinda , David Arthur H. G. , Cruz Carlos M. , Campaña Araceli G. , Messina Fabrizio
Published: January 2023

Nanographenes (NGs) have been attracting widespread interest since they combine peculiar properties of graphene with molecular features, such as bright visible photoluminescence. However, our understanding of the fundamental properties of NGs is still hampered by the high degree of heterogeneity usually characterizing most of these materials. In this context, NGs obtained by atomically precise synthesis routes represent optimal benchmarks to unambiguously relate their properties to well-defined structures. Here we investigate in deep detail the optical response of three curved hexa-peri-hexabenzocoronene (HBC) derivatives obtained by atomically precise synthesis routes. They are constituted by the same graphenic core, characterized by the presence of a heptagon ring determining a saddle distortion of their sp2 network, and differ from each other for slightly different edge functionalization. The quite similar structure allows for performing a direct comparison of their spectroscopic features, from steady-state down to the femtosecond scale, and precisely disentangling the role played by the different edge chemistry.
Engineering Properties of Green and Ecofriendly Grouting Materials with Different Sand Filling Ratios
Authors: Juang Chuen-Ul , Kuo Wen-Ten
Published: January 2023

With the active development of offshore wind power worldwide, the development of a green and ecofriendly grouting material (GEGM) has garnered global attention. Such a material must also be developed in Taiwan. Therefore, in this study, a series of environmentally friendly recycled materials were mixed in different proportions to develop a GEGM which can be implemented in the future construction of offshore wind turbines. To evaluate the mechanical properties of the GEGM, low water-to-binder (W/B) ratios (i.e., 0.21, 0.27, and 0.35) were used; cement was replaced with fixed amounts (20%) of ground granulated blast-furnace slag and fly ash; 2%, 2.5%, and 3% superplasticizers (SPs) were added; and two levels of sand content (60% and 70%) were used. The setting time of the GEGM was used to evaluate its workability; its compressive strength and flexural strength were used to evaluate its mechanical properties; and its sulfate resistance, length changes, and four-terminal resistance were used to evaluate its durability. The relationship between the durability and drying shrinkage of the GEGM was subsequently evaluated, and the ratio of final to initial setting times (F/I value) was calculated to determine the effects of the amount of SP added on workability. The highest F/I value (7.7) was achieved when 2 wt.% modified lignin sulfonate (MLS) was added because of the high viscosity of MLS, which compromised the workability of the concrete. The optimal compressive strength (83.62 MPa) was achieved when a W/B ratio of 0.21 was used, when the sand content was 70%, and when a 2% polycarboxylate superplasticizer (PCE) was added, whereas the optimal flexural strength (20.86 MPa) was achieved when 2.5% PCE was added. According to the nondestructive test results and the R2 value (>0.7) obtained from regression analyses of mechanical properties, the study results are reliable and may serve as a reference for future construction projects.
Self-Organization Effects of Thin ZnO Layers on the Surface of Porous Silicon by Formation of Energetically Stable Nanostructures
Authors: Murzalinov Danatbek , Kemelbekova Ainagul , Seredavina Tatyana , Spivak Yulia , Serikkanov Abay , Shongalova Aigul , Zhantuarov Sultan , Moshnikov Vyacheslav , Mukhamedshina Daniya
Published: January 2023

The formation of complex surface morphology of a multilayer structure, the processes of which are based on quantum phenomena, is a promising domain of the research. A hierarchy of pore of various sizes was determined in the initial sample of porous silicon by the atomic force microscopy. After film deposition by spray pyrolysis, ZnO nanoclusters regularly distributed over the sample surface were formed. Using the electron paramagnetic resonance (EPR) method it was determined that the localization of paramagnetic centers occurs more efficiently as a result of the ZnO deposition. An increase in the number of deposited layers, leads to a decrease in the paramagnetic center relaxation time, which is probably connected with the formation of ZnO nanocrystals with energetically stable properties. The nucleation and formation of nanocrystals is associated with the interaction of particles with an uncompensated charge. There is no single approach to determine the mechanism of this process. By the EPR method supplemented with the signal cyclic saturation, spectral manifestations from individual centers were effectively separated. Based on electron paramagnetic resonance and photoluminescence studies it was revealed that the main transitions between energy levels are due to oxygen vacancies and excitons.
Amino-Acid-Substituted Perylene Diimide as the Organic Cathode Materials for Lithium-Ion Batteries
Authors: Seong Honggyu , Nam Wonbin , Kim Geongil , Moon Joon Ha , Jin Youngho , Kwon Seung-Ryong , Lee Joon-Hwa , Choi Jaewon
Published: January 2023

One of the most effective cost reduction and green engineering projects is to introduce organic compounds to electrode materials instead of expensive inorganic-based materials. In this work, derivatives of perylene diimide substituted with amino acids (PDI_AAs) showed the characteristics of redox-active organic compounds and were, therefore, used as cathode materials of lithium-ion batteries (LIBs). Among the as-synthesized PDI_AAs, the L-alanine-substituted PDI (PDI_A) showed the most improved cycling performances of 86 mAhg−1 over 150 cycles with retention of 95% at 50 mAg−1. Furthermore, at a high current density of 500 mAg−1, PDI_A exhibited a long-term cycling performance of 47 mAhg−1 (retention to 98%) over 5000 cycles. In addition, ex situ attenuated total reflection Fourier-transform infrared spectroscopy (ATR FT-IR) analysis of electrodes at various charging states showed the mechanism of the charge-discharge process of PDI_A.
A High Performance Triboelectric Nanogenerator Based on MXene/Graphene Oxide Electrode for Glucose Detection
Authors: Yang Wei , Cai Xu , Guo Shujun , Wen Long , Sun Zhaoyang , Shang Ruzhi , Shi Xin , Wang Jun , Chen Huamin , Li Zhou
Published: January 2023

A smart sensing platform based on a triboelectric nanogenerator (TENG) possesses various advantages such as self-powering, convenience, real-time and biocompatibility. However, the detection limit of the TENG-based sensor is required to be improved. In this study, a high performance TENG-based glucose sensor was proposed by using the Ti3C2Tx (MXene)/graphene oxide (GO) composite electrode. The MXene and GO nanosheets are popular 2D materials which possessed high conductivity and a rich surface functional group. The MXene/GO thin films were prepared through electrostatic self-assembly technology, which can effectively impede the agglomeration of two nanoflakes. The as-prepared MXene/GO film presented outstanding mechanical property. To figure out the relationship between the nanostructure of MXene/GO film and the TENG, a series of MXene/GO-based TENG with different GO sizes was characterized. As a result, the TENG with 400 nm GO demonstrated the highest output performance. Subsequently, the optimized TENG was used in glucose detection application without the assistance of a glucose enzyme. This simple and flexible TENG shows promising potential in biosensors and non-invasive health monitoring.
Effect of Cutting Fluid on Machined Surface Integrity and Corrosion Property of Nickel Based Superalloy
Authors: Chen Shiqi , Yan Pei , Zhu Junyi , Wang Yubin , Zhao Wenxiang , Jiao Li , Wang Xibin
Published: January 2023

Superalloy parts place high demands on machined surface integrity and serviceability. In the machining process of superalloys, the cutting fluid is usually used to improve the machining performance. Cutting fluids with cooling and lubrication functions have a relatively large effect on the surface microstructure and residual stress as well. The corrosion damage caused by cutting fluid to the machined surface, during machining and residual, are also worth considering. In this paper, the machining performance of typical binary Ni Cr solid solution, age-hardened, nickel-based superalloy NiCr20TiAl T6, under two commonly used cutting fluids, Blasocut and E709, was analyzed, including cutting performance, surface quality, machining surface corrosion characteristics, and so on. The results showed that the surface residual stress could be improved by adding both cutting fluids compared with the deionized water. Blasocut had better lubrication properties, which could reduce friction and heat production. Pitting holes were found on the polished surface after 45 days with E709 cutting fluid, which was more corrosive than Blasocut. According to this research, a reasonable cutting fluid can be selected to reduce the surface corrosion and improve the service life and performance of parts.
A Thermally Controlled Multifunctional Metamaterial Absorber with Switchable Wideband Absorption and Transmission at THz Band
Authors: Wang Liansheng , Fu Quanhong , Wen Fusan , Zhou Xia , Ding Xueyong , Wang Yuan
Published: January 2023

This paper proposes a thermally controlled multifunctional metamaterial absorber with switchable wideband absorption and transmission at the THz band based on resistive film and vanadium dioxide (VO2). The function of the absorber can be adjusted by changing the phase transition characteristics of VO2. When VO2 is in a metallic state, the absorber can achieve wideband absorption with above 90% absorption from 3.31 THz to 10 THz and exhibits excellent absorption performance under a wide range of incident and polarization angles. When VO2 is in an insulating state, the metamaterial acts in transmission mode with a transmission coefficient of up to 61% at 5.15 THz. The transmission region is inside the absorption band, which is very important for practical applications. It has the advantages of having a simple structure, wideband absorption, and switchable absorption/transmission with potential application value in the fields of stealth of communication equipment and radar at the THz band.
Research on Explosive Hardening of Titanium Grade 2
Authors: Gloc Michał , Przybysz-Gloc Sylwia , Wachowski Marcin , Kosturek Robert , Lewczuk Rafał , Szachogłuchowicz Ireneusz , Paziewska Paulina , Maranda Andrzej , Ciupiński Łukasz
Published: January 2023

In this investigation, three different explosive materials have been used to improve the properties of titanium grade 2: ammonal, emulsion explosives, and plastic-bonded explosives. In order to establish the influence of explosive hardening on the properties of the treated alloys, tests were conducted, including microhardness testing, microstructure analysis, and tensile and corrosion tests. It has been found that it is possible to achieve a 40% increase in tensile strength using a plastic explosive (PBX) as an explosive material. On the other hand, the impact of the shock wave slightly decreased the corrosion resistance of titanium grade 2. The change in corrosion rate is less than 0.1µm/year, which does not significantly affect the overall corrosion resistance of the material. The reduction in corrosion resistance is probably due to the surface geometry changes as a result of explosive treatment.
Study on Mechanical Failure Behavior of Steel-Wire Wound Reinforced Thermoplastic Pipe under Combined Internal Pressure and Soil Landslide Conditions
Authors: Shi Jun , Hu Zhijie , Zeng Li , Lu Panlin , Chen Hanxin , Yu Nanming , Li Xiang
Published: January 2023

A steel-wire wound reinforced thermoplastic pipe (SWW-RTP) has been widely utilized in many industrial areas, and a soil landslide is an inevitable hazardous extreme condition for the SWW-RTP as it is usually buried underground. It is imperative to study the mechanical failure behavior and the failure criterion of the SWW-RTP under the combination of internal pressure and soil landslide conditions, and this paper is the first study to investigate the topic. In this paper, groups of stress–strain curves of high-density polyethylene (HDPE) and steel wires were obtained by uniaxial tensile tests at different strain rates, with the help of a Digital Image Correlation device (DIC). A rate-dependent constitutive model was employed to represent the mechanical behavior of the HDPE and to help deduce the stress–strain curve of the HDPE under the required strain rate, estimated from the static simplification of the dynamic soil landslide. Afterwards, a finite element model of the SWW-RTP, embedded in a cubic of soil, was established with the software ABAQUS. The SWW-RTP model was composed of HDPE solid elements, embedded with steel-wire truss elements, and the soil was characterized with the extended Drucker–Prager model. A quartic polynomial displacement distribution was applied to the soil model to represent the soil landslide. Then, the mechanical response of the SWW-RTP was analyzed. It was found that the failure criterion of the HDPE yield was more suitable for the pipe subjected to internal pressure and soil landslide conditions, instead of the steel-wire strength failure criterion always used in traditional research on the SWW-RTP. Further, the influence of landslide width, internal pressure and steel-wire number were discussed. The larger the width of the landslide area, the gentler the deformation of the pipeline; this resulted in an increase in the maximum landslide and a decrease in the maximum curvature with the width of the landslide area. The relatively high internal pressure was beneficial to the safety of the SWW-RTP under landslide, because the internal pressure could increase the stiffness of the pipeline. The number of steel wires had a limited influence on the maximum landslide required for the SWW-RTP’s failure. This work can be useful for the design and safe assessment of the SWW-RTP under internal pressure and soil landslide conditions.
Design Improvement of Four-Strand Continuous-Casting Tundish Using Physical and Numerical Simulation
Authors: Li Quanhui , Qin Bangming , Zhang Jiangshan , Dong Hongbiao , Li Ming , Tao Biao , Mao Xinping , Liu Qing
Published: January 2023

The flow pattern is vital for the metallurgical performance of continuous casting tundishes. The purpose of this study was to design and optimize the flow characteristics inside a four-strand tundish. Numerical simulations and water model experiments were validated and utilized to investigate the flow behavior. The effect of different flow rates in the original tundish was evaluated; two modified retaining walls and a new ladle shroud were designed for optimization. The molten steel inside the original tundish tends to be more active as the flow rate increases from 3.8 L/min to 6.2 L/min, which results in a reduction in dead volume from 36.47% to 17.59% and better consistency between different outlets. The dead volume and outlet consistency inside the tundish are improved significantly when the modified walls are applied. The proper design of the diversion hole further enhances the plug volume from 6.39% to 13.44% of the tundish by forming an upstream circular flow in the casting zone. In addition, the new trumpet ladle shroud demonstrates an advantage in increasing the response time from 152.5 s to 167.5 s and alleviating the turbulence in the pouring zone, which is beneficial for clean steel production.
Computer Simulations of End-Tapering Anchorages of EBR FRP-Strengthened Prestressed Concrete Slabs at Service Conditions
Authors: Wattanapanich Chirawat , Imjai Thanongsak , Garcia Reyes , Rahim Nur Liza , Abdullah Mohd Mustafa Al Bakri , Sandu Andrei Victor , Vizureanu Petrica , Matasaru Petre Daniel , Thomas Blessen Skariah
Published: January 2023

This article examines numerically the behavior of prestressed reinforced concrete slabs strengthened with externally bonded reinforcement (EBR) consisting of fiber-reinforced polymer (FRP) sheets. The non-linear finite element (FE) program Abaqus® is used to model EBR FRP-strengthened prestressed concrete slabs tested previously in four-point bending. After the calibration of the computational models, a parametric study is then conducted to assess the influence of the FRP axial stiffness (thickness and modulus of elasticity) on the interfacial normal and shear stresses. The numerical analysis results show that increasing the thickness or the elastic modulus of the FRP strengthening affects the efficiency of the FRP bonding and makes it susceptible to earlier debonding failures. A tapering technique is proposed in wet lay-up applications since multiple FRP layers are often required. It is shown that by gradually decreasing the thickness of the FRP strengthening, the concentration of stress along the plate end can be reduced, and thus, the overall strengthening performance is maximized. The tapering is successful in reducing the bond stress concentrations by up to 15%, which can be sufficient to prevent concrete rip-off and peel-off debonding failure modes. This article contributes towards a better understanding of the debonding phenomena in FRP-strengthened elements in flexure and towards the development of more efficient computational tools to analyze such structures.
Modification of Some Structural and Functional Parameters of Living Culture of Arthrospira platensis as the Result of Selenium Nanoparticle Biosynthesis
Authors: Cepoi Liliana , Zinicovscaia Inga , Chiriac Tatiana , Rudi Ludmila , Yushin Nikita , Grozdov Dmitrii , Tasca Ion , Kravchenko Elena , Tarasov Kirill
Published: January 2023

Selenium nanoparticles are attracting the attention of researchers due to their multiple applications, including medicine. The biosynthesis of selenium nanoparticles has become particularly important due to the environmentally friendly character of the process and special properties of the obtained particles. The possibility of performing the biosynthesis of selenium nanoparticles via the living culture of Arthrospira platensis starting from sodium selenite was studied. The bioaccumulation capacity of the culture, along with changes in the main biochemical parameters of the biomass, the ultrastructural changes in the cells during biosynthesis and the change in the expression of some genes involved in stress response reactions were determined. Protein, lipid and polysaccharide fractions were obtained from the biomass grown in the presence of sodium selenite. The formation of selenium nanoparticles in the protein fraction was demonstrated. Thus, Arthrospira platensis culture can be considered a suitable matrix for the biosynthesis of selenium nanoparticles.
Bitumen Aging—Laboratory Simulation Methods Used in Practice and Selected Directions of Research on New Methods
Authors: Czajkowski Paweł , Przyjazny Andrzej , Boczkaj Grzegorz
Published: January 2023

Changes in the properties of bitumen binders that occur as a result of aging have a huge impact on the durability of products produced from them. In particular, asphalt pavements, which constitute the most common use of petroleum bitumen, are susceptible to damage resulting from the increasing stiffness of the bitumen during its life cycle. Increased stiffness of asphalt pavements reduces the pavement resistance to low-temperature cracks and fatigue cracks, ultimately leading to the loss of their functional properties and the need for road repair. The rate of changes in bitumen properties is influenced by many factors, the most important of which are environmental conditions, technological parameters of binder processing, and physicochemical properties. The greatest impact on minimizing the adverse effect of aging is the use of bitumen suitably resistant to aging, and changing the technological parameters of its application. This article reviews the literature and standardized test methods of bitumen aging, with a focus on the methods that are most often used in practice, to evaluate the suitability of bitumen for use in road construction. The presented methods are limited to aging simulation. This mini-review presents the most important stages of aging procedures, their advantages and limitations, as identified by the authors of this publication for different types of bitumen. Moreover, the most important directions of developments in the field of new laboratory aging tests are highlighted. The suggestions are based on the industrial practice of the authors of this review, taking into account identified demands for quality control in the industry.
Trifluoromethylated 4,5-Dihydro-1,2,4-triazin-6(1H)-ones via (3+3)-Annulation of Nitrile Imines with α-Amino Esters
Authors: Kowalczyk Anna , Świątek Kamil , Celeda Małgorzata , Utecht-Jarzyńska Greta , Jaskulska Agata , Gach-Janczak Katarzyna , Jasiński Marcin
Published: January 2023

The synthesis of two series of monocyclic and bicyclic trifluoromethylated 4,5-dihydro-1,2,4-triazin-6(1H)-one derivatives based on (3+3)-annulation of methyl esters derived from natural α-amino acids with in situ generated trifluoroacetonitrile imines has been described. The devised protocol is characterized by a wide scope, easily accessible substrates, remarkable functional group tolerance, and high chemical yield. In reactions with chiral starting materials, no racemization at the stereogenic centers was observed and the respective enantiomerically pure products were obtained. Selected functional group interconversions carried out under catalytic hydrogenation and mild PTC oxidation conditions were also demonstrated.
Characterization of Biodegradable Food Contact Materials under Gamma-Radiation Treatment
Authors: Wiszumirska Karolina , Czarnecka-Komorowska Dorota , Kozak Wojciech , Biegańska Marta , Wojciechowska Patrycja , Jarzębski Maciej , Pawlak-Lemańska Katarzyna
Published: January 2023

Radiation is an example of one of the techniques used for pasteurization and sterilization in various packaging systems. There is a high demand for the evaluation of the possible degradation of new composites, especially based on natural raw materials. The results of experimental research that evaluated the impact of radiation technology on biodegradable and compostable packaging materials up to 40 kGy have been presented. Two commercially available flexible composite films based on aliphatic–aromatic copolyesters (AA) were selected for the study, including one film with chitosan and starch (AA-CH-S) and the other with thermoplastic starch (AA-S). The materials were subjected to the influence of ionizing radiation from 10 to 40 kGy and then tests were carried out to check their usability as packaging material for the food industry. The results showed that the mechanical properties of AA-S films improved due to the radiation-induced cross-linking processes, while in the case of AA-CH-S films, a considerable decrease in the elongation at break was observed. The results also showed a decrease in the WVTR in the case of AA-S and no changes in barrier properties in the case of AA-CH-S. Both materials revealed no changes in the odor analyzed by sensory analysis. In the case of the AA-S films, the higher the radiation dose, the faster the biodegradation rate. In the case of the AA-CH-S film, the radiation did not affect biodegradation. The performed research enables the evaluation of the materials intended for direct contact with food. AA-CH-S was associated with unsatisfactory parameters (exceeding the overall migration limit and revealing color change during storage) while AA-S showed compliance at the level of tests carried out. The study showed that the AA-CH-S composite did not show a synergistic effect due to the presence of chitosan.
Osteogenic Potential of a Polyethylene Glycol Hydrogel Functionalized with Poly-Lysine Dendrigrafts (DGL) for Bone Regeneration
Authors: Roumani Sandra , Jeanneau Charlotte , Giraud Thomas , Cotten Aurélie , Laucournet Marc , Sohier Jérôme , Pithioux Martine , About Imad
Published: January 2023

Resorbable hydrogels are widely used as scaffolds for tissue engineering. These hydrogels can be modified by grafting dendrimer-linked functionalized molecules (dendrigrafts). Our aim was to develop a tunable poly(L-lysine) dendrigrafts (DGL)/PEG-based hydrogel with an inverse porosity and to investigate its osteogenic potential. DGL/PEG hydrogels were emulsified in a surfactant-containing oil solution to form microspheres. The toxicity was evaluated on Human Vascular Endothelial Cells (HUVECs) and Bone Marrow Mesenchymal Stem Cells (hMSCs) with Live/Dead and MTT assays. The effects on HUVECs were investigated through C5 Complement expression by RT-PCR and C5a/TGF-β1 secretion by ELISA. Recruitment of hMSCs was investigated using Boyden chambers and their osteogenic differentiation was studied by measuring Alkaline Phosphatase activity (ALP) and BMP-2 secretion by ELISA. Adjusting the stirring speed during the emulsification allowed to obtain spherical microspheres with tunable diameters (10–1600 µm). The cell viability rate with the hydrogel was 95 and 100% with HUVECs and hMSCs, respectively. Incubating HUVECs with the biomaterial induced a 5-fold increase in TGF-β1 and a 3-fold increase in Complement C5a release. Furthermore, HUVEC supernatants obtained after incubation with the hydrogel induced a 2.5-fold increase in hMSC recruitment. The hydrogel induced a 3-fold increase both in hMSC ALP activity and BMP-2 secretion. Overall, the functionalized hydrogel enhanced the osteogenic potential by interacting with endothelial cells and hMSCs and represents a promising tool for bone tissue engineering.
Influence of Waste Basalt Powder Addition on the Microstructure and Mechanical Properties of Autoclave Brick
Authors: Kostrzewa-Demczuk Paulina , Stepien Anna , Dachowski Ryszard , Silva Rogério Barbosa da
Published: January 2023

In the production of building materials, there has been an increased interest in the use of by-products and industrial waste in recent years. Such modifications make it possible to solve not only technical and economic problems, but also environmental problems. This article describes the use of basalt powder waste in sand-lime products (silicates). The aim of the study was to manage basalt powder waste and to investigate the changes it causes in sand-lime products. The article describes the planning of the experiment, which directly determines the number of samples and their composition, which was necessary to conducting a full analysis and correctly illustrating the relationships occurring in the samples. Basic tests were carried out: compressive strength, density and water absorption, as well as optical tests and scanning microscopy. Based on the research conducted, it was concluded that the use of basalt powder as a component of sand-lime products has positive effects. Studies show that the best results are achieved with a proportion of powder in the raw material mass of about 10%—the compressive strength reaches almost 30 MPa, which is almost twice that of traditional silicate.
MicroRNAs: Small Molecules with Significant Functions, Particularly in the Context of Viral Hepatitis B and C Infection
Authors: Megahed Fayed , Tabll Ashraf , Atta Shimaa , Ragheb Ameera , Smolic Robert , Petrovic Ana , Smolic Martina
Published: January 2023

A MicroRNA (miRNA) is defined as a small molecule of non-coding RNA (ncRNA). Its molecular size is about 20 nucleotides (nt), and it acts on gene expression’s regulation at the post-transcription level through binding to the 3’untranslated regions (UTR), coding sequences, or 5’UTR of the target messenger RNAs (mRNAs), which leads to the suppression or degradation of the mRNA. In recent years, a huge evolution has identified the origin and function of miRNAs, focusing on their important effects in research and clinical applications. For example, microRNAs are key players in HCV infection and have important host cellular factors required for HCV replication and cell growth. Altered expression of miRNAs affects the pathogenicity associated with HCV infection through regulating different signaling pathways that control HCV/immunity interactions, proliferation, and cell death. On the other hand, circulating miRNAs can be used as novel biomarkers and diagnostic tools for HCV pathogenesis and early therapeutic response. Moreover, microRNAs (miRNA) have been involved in hepatitis B virus (HBV) gene expression and advanced antiviral discovery. They regulate HBV/HCV replication and pathogenesis with different pathways involving facilitation, inhibition, activation of the immune system (innate and adaptive), and epigenetic modifications. In this short review, we will discuss how microRNAs can be used as prognostic, diagnostic, and therapeutic tools, especially for chronic hepatitis viruses (HBV and HCV), as well as how they could be used as new biomarkers during infection and advanced treatment.
Auricular Acupressure for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Huang Qiong , Zhan Mengqi , Hu Zhe
Published: January 2023

Background and Objectives: The purpose of this systematic review was to summarize the current evidence to examine the safety and effectiveness of auricular acupressure on dry eye diseases. Materials and Methods: Twenty databases were searched from their inception until November 2022. Only randomized controlled trials (RCTs) in which auricular acupressure was used for dry eye diseases were included. The selection process, data extraction and quantitative were conducted according to the guidelines. Results: Seven RCTs met the inclusion criteria. Meta-analysis showed that compared to artificial tears, auricular acupressure had a favorable effect on prolonging tear breakup time (TBUT), improving the Schirmer I test (SIT) score and the score of symptoms (SOS) of patients with dry eye disease (p < 0.05). Furthermore, compared to the artificial tears alone, auricular acupressure plus artificial tears had a significantly greater SIT score (p < 0.001) and response rate (p = 0.006), significantly longer TBUT (p < 0.001), and significantly lower Ocular surface disease index (OSDI) (p = 0.02) and SOS (p = 0.03). However, there was no statistically significant difference between the auricular acupressure plus artificial tears group and the artificial tears group in terms of cornea fluorescein staining (CFS) (p = 0.09). Conclusions: Auricular acupressure, as a sole intervention or in combination with artificial tears, may have a beneficial effect on dry eye disease. However, more high-quality RCTs need to be included in the future to further prove the positive effects of auricular acupressure on patients with dry eye disease.
A Nonrandomized Phase 2 Trial of EG-Mirotin, a Novel, First-in-Class, Subcutaneously Deliverable Peptide Drug for Nonproliferative Diabetic Retinopathy
Authors: Yoo Seunghoon , You Dae Hyuk , Lee Jeongyoon , Hong H. Christian , Lee Sung Jin
Published: January 2023

Background and objectives: EG-Mirotin (active ingredient EGT022) targets nonproliferative diabetic retinopathy (NPDR), the early stage of retinopathy. EG-Mirotin reverses capillary damage before NPDR progresses to an irreversible stage. EG-Mirotin safety and efficacy were investigated in patients with type 1 or type 2 diabetes mellitus and moderate to severe NPDR. Methods: In this open-label, single-arm, single-center, exploratory phase II study, 10 patients (20 eyes) received EG-Mirotin once a day (3 mg/1.5 mL sterile saline) for 5 days and were evaluated for ischemic index changes and safety. End of study was approximately 8 ± 1 weeks (57 ± 7 days) after the first drug administration. Results: EG-Mirotin injections were well tolerated, with no dose-limiting adverse events, serious adverse events, or deaths. Four treatment-emergent adverse events (TEAEs) unrelated to the investigational drug were observed in 2 out of 10 participants (20%) who had received the investigational drug. The overall average percent change in ischemic index at each evaluation point compared with baseline was statistically significant (Greenhouse–Geisser F = 9.456, p = 0.004 for the main effect of time), and a larger change was observed when the baseline ischemic index value was high (Greenhouse–Geisser F = 10.946, p = 0.002 for time × group interaction). Conclusions: The EG-Mirotin regimen established in this study was shown to be feasible and safe and was associated with a trend toward potential improvement in diabetes-induced ischemia and retinal capillary leakage.
Clinical Inertia in the Management of Type 2 Diabetes Mellitus: A Systematic Review
Authors: Almigbal Turky H. , Alzarah Sarah A. , Aljanoubi Flwah A. , Alhafez Nouryah A. , Aldawsari Munirah R. , Alghadeer Zahraa Y. , Alrasheed Abdullah A.
Published: January 2023

This review seeks to establish, through the recent available literature, the prevalence of therapeutic intensification delay and its sequences in poorly controlled Type 2 Diabetes Mellitus (T2DM) patients. The strategy identified studies exploring the clinical inertia and its associated factors in the treatment of patients with T2DM. A total of 25 studies meeting the pre-established quality criteria were included in this review. These studies were conducted between 2004 and 2021 and represented 575,067 patients diagnosed with T2DM. Trusted electronic bibliographic databases, including Medline, Embase, and the Cochrane Central Register of Controlled Trials, were used to collect studies by utilizing a comprehensive set of search terms to identify Medical Subject Headings (MeSH) terms. Most o the studies included in this review showed clinical inertia rates over 50% of T2DM patients. In the USA, clinical inertia ranged from 35.4% to 85.8%. In the UK, clinical inertia ranged from 22.1% to 69.1%. In Spain, clinical inertia ranged from 18.1% to 60%. In Canada, Brazil, and Thailand, clinical inertia was reported as 65.8%, 68%, and 68.4%, respectively. The highest clinical inertia was reported in the USA (85.8%). A significant number of patients with T2DM suffered from poor glycemic control for quite a long time before treatment intensification with oral antidiabetic drugs (OADs) or insulin. Barriers to treatment intensification exist at the provider, patient, and system levels. There are deficiencies pointed out by this review at specialized centers in terms of clinical inertia in the management of T2DM including in developed countries. This review shows that the earlier intensification in the T2DM treatment is appropriate to address issues around therapeutic inertia.
Recent Advances in Transition Metal Tellurides (TMTs) and Phosphides (TMPs) for Hydrogen Evolution Electrocatalysis
Authors: Shah Syed Shoaib Ahmad , Khan Naseem Ahmad , Imran Muhammad , Rashid Muhammad , Tufail Muhammad Khurram , Rehman Aziz ur , Balkourani Georgia , Sohail Manzar , Najam Tayyaba , Tsiakaras Panagiotis
Published: January 2023

The hydrogen evolution reaction (HER) is a developing and promising technology to deliver clean energy using renewable sources. Presently, electrocatalytic water (H2O) splitting is one of the low-cost, affordable, and reliable industrial-scale effective hydrogen (H2) production methods. Nevertheless, the most active platinum (Pt) metal-based catalysts for the HER are subject to high cost and substandard stability. Therefore, a highly efficient, low-cost, and stable HER electrocatalyst is urgently desired to substitute Pt-based catalysts. Due to their low cost, outstanding stability, low overpotential, strong electronic interactions, excellent conductivity, more active sites, and abundance, transition metal tellurides (TMTs) and transition metal phosphides (TMPs) have emerged as promising electrocatalysts. This brief review focuses on the progress made over the past decade in the use of TMTs and TMPs for efficient green hydrogen production. Combining experimental and theoretical results, a detailed summary of their development is described. This review article aspires to provide the state-of-the-art guidelines and strategies for the design and development of new highly performing electrocatalysts for the upcoming energy conversion and storage electrochemical technologies.
Interpretable Calibration of Crystal Plasticity Model Using a Bayesian Surrogate-Assisted Genetic Algorithm
Authors: Yang Shuaiyi , Tang Xuefeng , Deng Lei , Gong Pan , Zhang Mao , Jin Junsong , Wang Xinyun
Published: January 2023

The accurate calibration of material parameters in crystal plasticity models is essential for applying crystal plasticity (CP) simulations. Identifying these parameters usually requires unfeasible single-crystal experiments or expensive time costs due to the use of traditional genetic algorithm (GA) optimization. This study proposed an efficient and interpretable method for calibrating the constitutive parameters with macroscopic mechanical tests. This approach utilized the Bayesian neural network (BNN)-based surrogate-assisted GA (SGA) optimization method to identify a group of constitutive parameters that can reproduce the experimental stress–strain curve and crystallographic orientation by crystal plasticity simulation. The proposed approach was performed on the calibration of typical high-entropy alloy material parameters in two different CP models. The use of the surrogate model reduces the call count of simulation in the parameter searching process and speeds up the calibration significantly. With the help of infill sampling, the accuracy of this optimization method is consistent with the CP simulation and not limited by the accuracy of the surrogate model. Another merit of this method is that the pattern that the BNN surrogate found in the model parameters can be interpreted with its integrated gradients, which helps us to understand the relationship between constitutive parameters and the output mechanical response. The interpretation of BNN can guide further experiment design to decouple particular parameters and add constraints provided by the attached experiment or prior knowledge.
Effect of EMBr on Flow in Slab Continuous Casting Mold and Industrial Experiment of Nail Dipping Measurement
Authors: Zhang Limin , Xiao Pengcheng , Wang Yan , Zhang Caijun , Zhu Liguang
Published: January 2023

In this study, a funnel mold (FM) model of a multi-mode electromagnetic braking (EMBr) device was developed, and the magnetic flux density at different currents was obtained by MAXWELL software. By using the magnetohydrodynamics (MHD) module of FLUENT software, the volume of fluid binomial flow turbulence model and the EMBr mathematical model of the steel/slag flow field were coupled, and the characteristics of the molten steel flow and the liquid-level fluctuation in the 1520 mm × 90 mm FM with the casting speed of 6 m/min were calculated under the effect of the electromagnetic field. The FM liquid-level characteristic information under production conditions was obtained in a nail board industrial experiment and compared with the magnetic-fluid coupling model. The results show that the EMBr can significantly change the flow behavior of molten steel. When the magnetic pole current is not less than 800-600 A, the maximum liquid-level fluctuation height decreases from 18 mm without EMBr to less than 5 mm, and the liquid-level cannot easily entrap slag. Considering the EMBr effect and production cost, the reasonable magnetic pole current should be 800-600 A. The reliability of numerical simulation was also verified by the industrial test results of the nail board.
The Preparation, Corrosion Resistance and Formation Mechanism of a New-Type Mo-Based Composite Conversion Coating on 6061 Aluminum Alloy
Authors: Qian Xuzheng , Huang Feng , Teng Xu , Wang Yiqun , Fang Yingsong , Pan Jingjing , Wang Wenhao , Li Yingpeng , Zhan Wen
Published: January 2023

This paper aims to explore a new-type Mo-based composite conversion coating on 6061 aluminum alloy, systematically evaluate its corrosion resistance, and further reveal the formation mechanism. The effects of pH, conversion time (CTI) and H2ZrF6 content on the corrosion resistance were determined by the dropping test and electrochemical tests, and the average corrosion rate (ACR) in neutral 3.5 wt.% NaCl solution under different temperatures was calculated by the immersion test. The micro-morphology and phase compositions were systematically investigated by SEM, EDS and XPS. The results showed that the optimal pH and CTI were 4.5 and 12 min respectively, and the most suitable addition amount of H2ZrF6 was 1.2 mL/L. The micro-morphology of the Mo/Ti/Zr conversion coating (MoTiZrCC) under the best conversion condition was relatively smooth and dense, and its phase compositions mainly consisted of MoO3, Mo2O5, TiO2, ZrO2 and Al2O3. The MoTiZrCC could significantly improve corrosion resistance with the lower icorr and higher Rp, and the ACR of the MoTiZrCC could be reduced to 16.7% of the Al alloy matrix. Additionally, based on the above results, the formation mechanism for the MoTiZrCC was logically deduced.
Machine Learning Potential Model Based on Ensemble Bispectrum Feature Selection and Its Applicability Analysis
Authors: Jiang Jiawei , Xu Li-Chun , Li Fenglian , Shao Jianli
Published: January 2023

With the continuous improvement of machine learning methods, building the interatomic machine learning potential (MLP) based on the datasets from quantum mechanics calculations has become an effective technical approach to improving the accuracy of classical molecular dynamics simulation. The Spectral Neighbor Analysis Potential (SNAP) is one of the most commonly used machine learning potentials. It uses the bispectrum to encode the local environment of each atom in the lattice. The hyperparameter jmax controls the mapping complexity and precision between the local environment and the bispectrum descriptor. As the hyperparameter jmax increases, the description will become more accurate, but the number of parameters in the bispectrum descriptor will increase dramatically, increasing the computational complexity. In order to reduce the computational complexity without losing the computational accuracy, this paper proposes a two-level ensemble feature selection method (EFS) for a bispectrum descriptor, combining the perturbation method and the feature selector ensemble strategy. Based on the proposed method, the feature subset is selected from the original dataset of the bispectrum descriptor for building the dimension-reduced MLP. As a method application and validation, the data of Fe, Ni, Cu, Li, Mo, Si, and Ge metal elements are used to train the linear regression model based on SNAP for predicting these metals’ atomic energies and forces them to evaluate the performance of the feature subsets. The experimental results show that, compared to the features of SNAP and qSNAP, the training complexity improvement of our EFS method on the qSNAP feature is more effective than SNAP. Compared with the existing methods, when the feature subset size is 0.7 times that of the original features, the proposed EFS method based on the SSWRP ensemble strategy can achieve the best performance in terms of stability, achieving an average stability of 0.94 across all datasets. The training complexity of the linear regression model is reduced by about half, and the prediction complexity is reduced by about 30%.
Several Metabolite Families Display Inflexibility during Glucose Challenge in Patients with Type 2 Diabetes: An Untargeted Metabolomics Study
Authors: Fanni Giovanni , Eriksson Jan W. , Pereira Maria J.
Published: January 2023

Metabolic inflexibility is a hallmark of insulin resistance and can be extensively explored with high-throughput metabolomics techniques. However, the dynamic regulation of the metabolome during an oral glucose tolerance test (OGTT) in subjects with type 2 diabetes (T2D) is largely unknown. We aimed to identify alterations in metabolite responses to OGTT in subjects with T2D using untargeted metabolomics of both plasma and subcutaneous adipose tissue (SAT) samples. Twenty subjects with T2D and twenty healthy controls matched for sex, age, and body mass index (BMI) were profiled with untargeted metabolomics both in plasma (755 metabolites) and in the SAT (588) during an OGTT. We assessed metabolite concentration changes 90 min after the glucose load, and those responses were compared between patients with T2D and controls. Post-hoc analyses were performed to explore the associations between glucose-induced metabolite responses and markers of obesity and glucose metabolism, sex, and age. During the OGTT, T2D subjects had an impaired reduction in plasma levels of several metabolite families, including acylcarnitines, amino acids, acyl ethanolamines, and fatty acid derivates (p < 0.05), compared to controls. Additionally, patients with T2D had a greater increase in plasma glucose and fructose levels during the OGTT compared to controls (p < 0.05). The plasma concentration change of most metabolites after the glucose load was mainly associated with indices of hyperglycemia rather than insulin resistance, insulin secretion, or BMI. In multiple linear regression analyses, hyperglycemia indices (glucose area under the curve (AUC) during OGTT and glycosylated hemoglobin (HbA1c)) were the strongest predictors of plasma metabolite changes during the OGTT. No differences were found in the adipose tissue metabolome in response to the glucose challenge between T2D and controls. Using a metabolomics approach, we show that T2D patients display attenuated responses in several circulating metabolite families during an OGTT. Besides the well-known increase in monosaccharides, the glucose-induced lowering of amino acids, acylcarnitines, and fatty acid derivatives was attenuated in T2D subjects compared to controls. These data support the hypothesis of inflexibility in several metabolic pathways, which may contribute to dysregulated substrate partitioning and turnover in T2D. These findings are not directly associated with changes in adipose tissue metabolism; therefore, other tissues, such as muscle and liver, are probably of greater importance.
CMP Pad Conditioning Using the High-Pressure Micro-Jet Method
Authors: Li Xin , Wang Yinggang , Chen Hongyu , Zhao Wenhong , Deng Qianfa , Yin Tengfei , To Suet , Sun Zhe , Shen Xi , Hang Wei , Yuan Julong
Published: January 2023

In this study, in order to improve and restore the performance of the polishing pads and reduce the cost of chemical mechanical polishing, three types of material polishing pads, namely, polyurethane, damping cloth, and non-woven fabric, were selected for the experiment. Accordingly, each polishing pad was set up with diamond conditioner and high-pressure micro-jet (HPMJ) conditioning control experiments. Subsequently, the fluctuation ranges of the material removal rate on the three polishing pads were 2.73–3.75 μm/h, 1.38–1.99 μm/h, and 2.36–4.32 μm/h, respectively under the HPMJ conditioning method, while the fluctuation ranges of the material removal rate on the three polishing pads were 1.80–4.14 μm/h, 1.02–2.09 μm/h, and 1.78–5.88 μm/h under the diamond conditioning method. Comparing the polishing pad morphologies under SEM, we observed that the surface of the polishing pad after HPMJ conditioning was relatively clean, and the hole structure was not blocked. Contrastingly, there remained numerous abrasive particles on the surface after the conventional diamond conditioning and the hole structure was blocked. Thus, the HPMJ conditioning technology is better than the traditional diamond conditioning technology. Subsequently, the polishing pad after HPMJ conditioning has a longer service life and a more stable material removal rate than that after traditional diamond conditioning.