bluuebunny/crossref_metadata_2025 huggingface dataset:
Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum
Authors: Sproule Thomas J. , Wilpan Robert Y. , Wilson John J. , Low Benjamin E. , Kabata Yudai , Ushiki Tatsuo , Abe Riichiro , Wiles Michael V. , Roopenian Derry C. , Sundberg John P.
Published: October 2023

The Lamc2jeb junctional epidermolysis bullosa (EB) mouse model has been used to demonstrate that significant genetic modification of EB symptoms is possible, identifying as modifiers Col17a1 and six other quantitative trait loci, several with strong candidate genes including dystonin (Dst/Bpag1). Here, CRISPR/Cas9 was used to alter exon 23 in mouse skin specific isoform Dst-e (Ensembl GRCm38 transcript name Dst-213, transcript ID ENSMUST00000183302.5, protein size 2639AA) and validate a proposed arginine/glutamine difference at amino acid p1226 in B6 versus 129 mice as a modifier of EB. Frame shift deletions (FSD) in mouse Dst-e exon 23 (Dst-eFSD/FSD) were also identified that cause mice carrying wild-type Lamc2 to develop a phenotype similar to human EB simplex without dystonia musculorum. When combined, Dst-eFSD/FSD modifies Lamc2jeb/jeb (FSD+jeb) induced disease in unexpected ways implicating an altered balance between DST-e (BPAG1e) and a rarely reported rodless DST-eS (BPAG1eS) in epithelium as a possible mechanism. Further, FSD+jeb mice with pinnae removed are found to provide a test bed for studying internal epithelium EB disease and treatment without severe skin disease as a limiting factor while also revealing and accelerating significant nasopharynx symptoms present but not previously noted in Lamc2jeb/jeb mice.
Assessing springtime vertebrate prey of sympatric mesopredators in the southeastern United States using metabarcoding analysis
Authors: Youngmann Jordan L. , Lance Stacey L. , Kilgo John C. , Ruth Charles , Cantrell Jay , D’Angelo Gino J.
Published: October 2023

Coyotes (Canis latrans) colonized the eastern United States over the last century and formed a 3-species predator guild with bobcats (Lynx rufus) and gray foxes (Urocyon cinereoargenteus) across much of the southeastern United States. Diets among the three species vary along with respective impacts on game species such as white-tailed deer (Odocoileus virginianus) and wild turkeys (Meleagris gallopavo). To determine predation impacts on vertebrate prey and dietary overlap in consumption of prey items, we assessed diets of coyote, bobcat, and gray fox during spring, coinciding with white-tailed deer fawning and wild turkey nesting and brood rearing. We sampled across three sites along the Savannah River in South Carolina from mid-May through mid-June of 2020–2021. We collected 180 scat samples along 295.9 kilometers (71.1–122.4 km/site) of unpaved secondary roads and used DNA metabarcoding to determine vertebrate diet items. We identified predator species of scat using DNA metabarcoding and species-specific mtDNA fragment analysis (153 were coyote, 20 bobcat, and seven gray fox). Overall, we found evidence that two species, coyote and bobcat, consumed deer while all three consumed turkeys. Frequency of deer in the diet varied across sites for coyotes from 62–86% and wild turkey was present with a frequency of occurrence of 9% for coyotes, 5% for bobcats, and 14% for gray fox. Vertebrate diet specialization was evident across predator species with high frequency of deer in coyote diets, rabbits and small mammals in bobcat diets, and herpetofauna in gray fox diets. During deer fawning and wild turkey nesting and brood rearing, dietary overlap appears to be mediated by disparate selection of prey items, which reduced competition among coyotes, bobcats, and gray foxes. Use of DNA metabarcoding may augment our understanding of dietary preferences within this predator guild by providing increased resolution of diet composition among important game species.
A complexity-informed in-depth case study into the sustainability and impact of a culture of health: The TR14ers community youth dance group
Authors: Williams Andrew James , Wyatt Katrina , Stevens Kelly , Price Lisa
Published: October 2023

There are calls for researchers to study existing community assets and activities that appear to improve health and have achieved longevity. The TR14ers Community Dance Charity Limited is a community youth dance group that has been running since 2005 providing free weekly sessions for children and adolescents in an economically disadvantaged town in the UK. An in-depth case study employing qualitative, quantitative and participatory methods was undertaken with the TR14ers (current participants and those who have left, co-ordinators and families) over 6 months with the aim of understanding the sustainable processes and impact of the Group. The 12 complex systems’ leverage points described by Meadows and the five domains of adolescent wellbeing developed by the United Nations H6+ Technical Working Group on Adolescent Health and Well-Being were used as frameworks to recognise the complexity of community assets like the TR14ers. The quantitative and qualitative data indicated that being part of the TR14ers contributed to multiple health and wellbeing outcomes. The positive experiences of being a TR14er led members to actively recruit others through word of mouth and public performances. Central to the TR14ers is a commitment to children’s rights, which is communicated formally and informally throughout the membership informing how and what the Group does, leading to the structure and delivery of the Group evolving over time. Members sought to ensure the sustainability of the Group after they had left and were keen to mentor younger members to develop and become the leaders. Based on the insights from this case study we suggest that efforts to develop cultures of health, like the TR14ers, should focus on the core values of the activity or intervention that underpin what it does and how within the local context.
New erythrocyte parameters derived from the Coulter principle relate with red blood cell properties—A pilot study in diabetes mellitus
Authors: Bourguignon Chloé , Ansel Clémentine , Gineys Jean-Philippe , Schuldiner Sophie , Isèbe Damien , Geitner Michael , Taraconat Pierre , Gris Jean-Christophe
Published: October 2023

In routine hematological instruments, blood cells are counted and sized by monitoring the impedance signals induced during their passage through a Coulter orifice. However, only signals associated with centered paths in the aperture are considered for analysis, while the rejected measurements, caused by near-wall trajectories, can provide additional information on red blood cells (RBC), as recent publications suggest. To assess usefulness of two new parameters in describing alterations in RBC properties, we performed a pilot study to compare blood samples from patients with diabetes mellitus (DM), frequent pathological condition associated with impairment in RBC deformability, versus controls. A total of 345 blood samples were analyzed: 225 in the DM group and 120 in the control group. A diagram of R and P, the two new parameters derived from the analysis of impedancemetry pulses, was used to compare distribution of RBC subpopulations between groups. To discriminate RBC from DM and control individuals, based on our multiparametric analysis, we built a score from variables derived from R/P matrix which showed good performances: area under the receiving operating characteristic curve 0.948 (0.920–0.970), p<0.0001; best discriminating value: negative predictive value 94.7%, positive predictive value was 78.4%. These results seem promising to approach RBC alterations in routine laboratory practice. The related potential clinically relevant outcomes remain to be investigated.
Transcriptomic data exploring the effect of agave fructans on the induction of the defense system in avocado fruit
Authors: Cuéllar-Torres Esther Angélica , Aguilera-Aguirre Selene , López-García Ulises Miguel , Hernández-Oñate Miguel Ángel , Montalvo-González Efigenia , Ortiz-Basurto Rosa Isela , Vega-Arreguín Julio , Chacón-López Alejandra
Published: October 2023

The effect of 20% high degree polymerized agave fructans (HDPAF) on the induction of the defense system in avocado fruits was investigated by transcriptomic analysis at 1, 24 and 72 h after treatment, and the effect of HDPAF on respiration rate and ethylene production was also analyzed. Transcriptomic profiling revealed 5425 differentially expressed genes (DEGs), 55 of which were involved in the pathways related to plant defense response to pathogens. Key genes were associated with phenylpropanoid biosynthesis, mitogen-activated protein signaling, plant hormone signaling, calcium ion signal decoding, and pathogenesis-related proteins. Dysregulated genes involved in ethylene biosynthesis were also identified, and the reduction in ethylene production by HDPAF was corroborated by gas chromatography, where three days of delayed peak production was observed compared to that in water-treated fruits. These results help to understand the mechanism of induction of the avocado defense system by applying HDPAF and support the application of HDPAF as an efficient postharvest treatment to extend the shelf life of the fruit.
Convolutional neural network model by deep learning and teaching robot in keyboard musical instrument teaching
Authors: Liu Jidong , Fu Fang
Published: October 2023

Keyboard instruments play a significant role in the music teaching process, providing students with an enjoyable musical experience while enhancing their music literacy. This study aims to investigate the current state of keyboard instrument teaching in preschool education, identify existing challenges, and propose potential solutions using the literature review method. In response to identified shortcomings, this paper proposes integrating intelligent technology and subject teaching through the application of teaching robots in keyboard instrument education. Specifically, a Convolutional Neural Network model of Deep Learning is employed for system debugging, enabling the teaching robot to analyze students’ images and movements during musical instrument play and deliver targeted teaching. Feedback from students who participated in keyboard instrument teaching with the robot indicates high satisfaction levels. This paper aims to diversify keyboard instruments’ teaching mode, introduce the practical application of robots in classroom teaching, and facilitate personalized teaching catering to individual students’ aptitudes.
Psychosocial and sociodemographic factors associated with gestational blood glucose levels in women attending public hospitals: Results from baseline of MAASTHI cohort
Authors: Shriyan Prafulla , Koya Srinidhi , Lobo Eunice , van Schayck Onno CP , Babu Giridhara R.
Published: October 2023

Background

Understanding psychosocial environment is important for improving maternal and fetal health outcomes during pregnancy. We aimed to identify the association between gestational blood glucose levels and psychosocial and demographic factors in pregnant women.

Methods

In the MAASTHI pregnancy cohort in Bengaluru, we assessed depressive symptoms, and social support using validated scales at baseline in first trimester. A 2-hour 75 g oral glucose tolerance test (OGTT) was administered between 24–36 weeks of gestation. We examined the relation between psychosocial factors assessed at baseline and gestational blood glucose levels in second/third trimester using multivariate linear regression and explored association between serum cortisol and gestational blood glucose levels in subgroup samples.

Results

We found that 9% of pregnant women had depressive symptoms and 14.3% had Gestational Diabetes Mellitus (GDM). Psychosocial factors, including depressive symptoms, have a significant correlation with gestational fasting(β = 0.12, p-value<0.05) and postprandial blood sugar level(β = 0.23, p-value<0.05) and poor social support were found to have a significant association with gestational fasting blood glucose levels(β = 1.45, p-value <0.05) and postprandial blood sugar levels(β = 2.60, p-value <0.05). The sociodemographic factors such as respondent education, occupation, social and economic status were associated with gestational blood sugar after adjusting for potential confounder variables.

Conclusion

Depressive symptoms and poor social support earlier in pregnancy were significantly associated with increased gestational blood glucose levels. Early detection and recognition of modifiable psychosocial risk factors can reduce glucose intolerance during pregnancy. Evaluating the benefits of screening for psychosocial factors and timely management of gestational diabetes mellitus can be helpful in India.
Associations of frailty with partial and absolute sedentary behaviours among older adults: A STROBE-compliant analysis of modifiability by gender and age
Authors: Asiamah Nestor , Khan Hafiz T. A. , Yarfi Cosmos , Agyemang Simon Mawulorm , Arthur-Mensah Jnr Reginald , Muhonja Faith , Sghaier Sarra , Kouveliotis Kyriakos
Published: October 2023

Background

Research shows that frailty is associated with higher sedentary behaviour, but the evidence to date regarding this association is inconclusive. This study assessed whether the above association is moderated or modified by gender and age, with sedentary behaviour measured with a more inclusive method.

Methods

This study adopted a STROBE-compliant cross-sectional design with sensitivity analyses and measures against common methods bias. The participants were community-dwelling older adults (mean age = 66 years) in two Ghanaian towns. A self-reported questionnaire was used to collect data from 1005 participants after the minimum sample size necessary was calculated. The hierarchical linear regression analysis was used to analyse the data.

Results

After adjusting for the ultimate confounders, frailty was associated with higher sedentary behaviour (β = 0.14; t = 2.93; p <0.05) as well as partial and absolute sedentary behaviour. Gender modified the above associations in the sense that frailty was more strongly associated with sedentary behaviour among women, compared with men. Age also modified the association between frailty and sedentary behaviour, which suggests that frailty was more strongly associated with higher sedentary behaviour at a higher age.

Conclusion

Sedentary behaviour could be higher at higher frailty among older adults. Frailty is more strongly associated with sedentary behaviour at a higher age and among women, compared with men.
12-week concurrent brisk walking and Taijiquan (Tai Chi) improve balance, flexibility, and muscular strength of Chinese older women
Authors: Bai Xiaorong , Xiao Wensheng , Soh Kim Geok , Agudamu  , Zhang Yang
Published: October 2023

Healthy aging is a global goal to enhance the quality of life for older persons. This study evaluated the benefits of 12-week concurrent brisk walking and Taijiquan. Healthy Chinese women aged 60 years and above were enrolled to the control (n = 26) and intervention (n = 25) groups. Participants in the intervention group engaged in three exercise sessions per week for 12 weeks, whereas control group engaged in free-living activities. Each exercise session consisted of 20–45 minutes of walking and 20–45 minutes of Yang style 24-form Taijiquan. 12-week exercise improved (p < 0.05) the sit and reach test (within-group mean difference: +5.6 cm; Hedges’ g = 0.77), handgrip strength (mean difference: +3.1 kg; g = 0.89), arm curl (mean difference: +2.1 repetitions; g = 0.69), chair stand (mean difference: +2.6 repetitions; g = 0.63), and one-legged standing (mean difference: +2.2 seconds; g = 1.07). There was no improvement in the circulatory health, body composition, or life satisfaction. Therefore, this concurrent brisk walking and Taijiquan training, which targets major whole-body muscle groups, could improve aging-critical flexibility, muscular fitness, and balance in older women. The exercise meets the current WHO guideline, is safe to perform, and could be campaigned as a health promotion for older persons.
Disentangling the latent space of GANs for semantic face editing
Authors: Niu Yongjie , Zhou Mingquan , Li Zhan
Published: October 2023

Disentanglement research is a critical and important issue in the field of image editing. In order to perform disentangled editing on images generated by generative models, this paper presents an unsupervised, model-agnostic, two-stage trained editing framework. This work addresses the problem of discovering interpretable, disentangled directions of edited image attributes in the latent space of generative models. This effort’s primary objective was to address the limitations discovered in previous research, mainly (a) the discovered editing directions are interpretable but significantly entangled, i.e., changes to one attribute affect the others and (b) Prior research has utilized direction discovery and direction disentanglement separately, and they can’t work synergistically. More specifically, this paper proposes a two-stage training method that discovers the editing direction with semantics, perturbs the dimension of the direction vector, adjusts it with a penalty mechanism, and makes the editing direction more disentangled. This allows easy distinguishable image editing, such as age and facial expressions in facial images. Experimentally compared to other methods, the proposed method outperforms them both qualitatively and quantitatively in terms of interpretability, disentanglement, and distinguishability of the generated images. The implementation of our method is available at https://github.com/ydniuyongjie/twoStageForFaceEdit.
How do industry and province attributes impact corporate contribution to poverty alleviation: A multilevel analysis
Authors: Chen Shuhan , Yang Guangqing
Published: October 2023

This study employs a multilevel model, nesting firm observations within industry and province groups, to investigate the influences on corporate contributions to poverty alleviation while considering the industrial and provincial contexts. Using a sample of Chinese firms listed in Shanghai and Shenzhen Stock Exchanges between 2016 and 2019, we find that Herfindah-Hirschman Index (HHI) does not affect corporate contribution. The results show a significantly negative relationship between industry dynamism and a firm’s substantial poverty contributions, as well as a significantly positive relationship between number of state-owned enterprises (SOEs) in industry and the likelihood and extent of a firm’s contributions. Moreover, a firm’s likelihood to participate in anti-poverty activities and make substantial contributions is affected by more intense government intervention and lower per capita GDP. A province’s poverty rate is positively associated with the extent of corporate investments in poverty alleviation. Additional analyses note that firms competitive in an industry that is less dynamic environment are more likely to invest funds into poverty alleviation instead of material contribution. Moreover, for firms headquartered in an industry with more SOEs and in provinces with a stronger government, a higher poverty rate and lower per capita GDP mean it is more likely for them to make both monetary and material contributions for anti-poverty campaigns.
Virally encoded interleukin-6 facilitates KSHV replication in monocytes and induction of dysfunctional macrophages
Authors: Shimoda Michiko , Inagaki Tomoki , Davis Ryan R. , Merleev Alexander , Tepper Clifford G. , Maverakis Emanual , Izumiya Yoshihiro
Published: October 2023

Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic double-stranded DNA virus and the etiologic agent of Kaposi’s sarcoma and hyperinflammatory lymphoproliferative disorders. Understanding the mechanism by which KSHV increases the infected cell population is crucial for curing KSHV-associated diseases. Using scRNA-seq, we demonstrate that KSHV preferentially infects CD14+ monocytes, sustains viral lytic replication through the viral interleukin-6 (vIL-6), which activates STAT1 and 3, and induces an inflammatory gene expression program. To study the role of vIL-6 in monocytes upon KSHV infection, we generated recombinant KSHV with premature stop codon (vIL-6(-)) and its revertant viruses (vIL-6(+)). Infection of the recombinant viruses shows that both vIL-6(+) and vIL-6(-) KSHV infection induced indistinguishable host anti-viral response with STAT1 and 3 activations in monocytes; however, vIL-6(+), but not vIL-6(-), KSHV infection promoted the proliferation and differentiation of KSHV-infected monocytes into macrophages. The macrophages derived from vIL-6(+) KSHV infection showed a distinct transcriptional profile of elevated IFN-pathway activation with immune suppression and were compromised in T-cell stimulation function compared to those from vIL-6(-) KSHV infection or uninfected control. Notably, a viral nuclear long noncoding RNA (PAN RNA), which is required for sustaining KSHV gene expression, was substantially reduced in infected primary monocytes upon vIL-6(-) KSHV infection. These results highlight the critical role of vIL-6 in sustaining KSHV transcription in primary monocytes. Our findings also imply a clever strategy in which KSHV utilizes vIL-6 to secure its viral pool by expanding infected monocytes via differentiating into longer-lived dysfunctional macrophages. This mechanism may facilitate KSHV to escape from host immune surveillance and to support a lifelong infection.
Bridging measurement and cultural interpretation: Experiencing the form-giving of men’s briefs
Authors: Herriott Richard
Published: October 2023

This article explores the first-hand experience of the diversity in styles of men’s briefs. It questions the standard categorization of briefs based on coverage and leg length. Due to the advent of internet-based sales channels, the scope for design has widened dramatically. The quality and experience of underwear styles is not captured in waistband dimensions and information on fabric. The article questions some ideas about designers’ ability to communicate product understanding given the tacit, non-verbal and haptic qualities inherent in briefs. It also raises questions about research paradigms common in industrial design research. This article is thus both about the subject (men’s briefs) and the means of research (research paradigm). The article combines aspects of design research used for industrial design and approaches such as wardrobe studies and interpretation used in fashion research.
Ricoeur between Ithaca and the isle of the Phaecians
Authors: Pierosara Silvia
Published: October 2023

The aim of this contribution is to critically engage with the ricoeurian reading of the topic of recognition in the Homeric poem Odyssey. The hypothesis presented here is that the ricoeurian reading shows only one side of the coin, since it is almost solely focused on the recognition received by Ulysses when he comes back to Ithaca incognito. Ricoeur stresses the unilaterality of recognition, which is only directed to re‑establish Ulysses’ power as king. Being recognized as the king of Ithaca does not imply, so Ricoeur’s argument goes, to recognize those who are subjected to him, and is a mere way of exhibiting power. But there is another possible reading of the scenes of recognition in the Odyssey, even if Ricoeur does not take them into account. Indeed, another moment of the recognition story can be found in the Isle of the Phaeacians, and it cannot be traced back to the “will to power”, but, rather, to Ulysses’s fragility. When Demodocus, the poet at the court of the king Alcinoos, starts singing the story of the famous hero Ulysses, who is there incognito, Ulysses cannot hold back his tears, and in the end he discloses his own identity. Here, Ulysses does not look for recognition, instead recognition is granted to him in an unexpected way. This act of recognition reveals all the fragility of the hero, who discovers himself in the words of others, and understands that he depends upon them to be, to exist, and, in the end, to come back home. This sort of “recognition by fragility” is possible due to a narrative dimension where Ulysses is hosted, and whose configurative and refigurative power makes the hero able to name his feeling as a feeling of “nostalgia”.
IMPENSABLE, INDISPENSABLE
Authors: Frey Daniel
Published: October 2023

Tão fecunda quanto paradoxal, a noção de clássico implica uma referência de excelência que só é reconhecida retrospectivamente, uma inserção histórica tanto quanto um valor intemporal, a autoridade de uma tradição bem como a liberdade criadora de uma apropriação actual, o elitismo da recepção aliado à popularidade do acesso. Após uma sinopse etimológica e lexicográfica, este artigo explora a noção de “clássico” na hermenêutica de Paul Ricœur. De facto, é todo o espectro da teoria da interpretação, mas também da tradução e da leitura, que pode ser mobilizado para tratar desta noção, ambivalente na própria utilização que dela faz o autor de Temps et Récit. A hermenêutica começa a ser a “arte de compreender os clássicos” no sentido lato do termo: textos sagrados e profanos na encruzilhada de horizontes geográficos e históricos. Explicação e compreensão, crítica e pertença, afastamento e desdistanciamento, são tantas dicotomias metodológicas através das quais se desenvolve a ideia do carácter plural e activo da recepção dos clássicos. Tanto quanto a sua teoria, é também a prática ricoeuriana que evidencia a sua concepção dos “clássicos”. Paul Ricœur é um leitor-pensador que mediatiza as tensões tanto quanto articula as oposições entre os autores canónicos a partir dos quais elabora o seu próprio pensamento. Estes são alguns dos desafios da impensabilidade e da indispensabilidade dos "clássicos" e da própria noção de "clássico".
De l’herméneutique, de la religion, et de la jeunesse de la pensée ricoeurienne: Entretien avec Daniel Frey
Authors: Marcelo Gonçalo , Portocarrero Maria Luísa , Frey Daniel
Published: October 2023

Nesta entrevista, conduzida por Gonçalo Marcelo e Maria Luísa Portocarrero, Daniel Frey, professor de filosofia da religião na Universidade de Estrasburgo e Presidente do Conselho Científico do Fonds Ricoeur, apresenta alguns aspetos centrais da sua investigação filosófica, do seu desenvolvimento intelectual e das atividades desenvolvidas no Fonds Ricoeur. Daniel Frey expõe a sua teoria hermenêutica da leitura, influenciada por Gadamer e Ricoeur, mostrando a especificidade da abordagem hermenêutica da leitura. Na entrevista, o autor também explora a importância da filosofia do jovem Ricoeur dos anos 1950‑1960, e a evolução da relação entre filosofia e religião em Ricoeur. Fazendo uma breve descrição do estatuto das obras que se tornam “clássicas” e dos projetos recentes do Fonds Ricoeur, como a digitalização dos arquivos de Ricoeur, esta entrevista de Daniel Frey mostra‑nos até que ponto o trabalho de Ricoeur se encontra hoje aberto a novas leituras e interpretações.
A Novel Goal oriented Sampling Method for Improving the Convergence Rate of Sampling based Path Planning for Autonomous Mobile Robot Navigation
Authors: Ganesan Sivasankar , Natarajan Senthil Kumar , Thondiyath Asokan
Published: October 2023

Autonomous Mobile Robots' performance relies on intelligent motion planning algorithms. In autonomous mobile robots, sampling-based path-planning algorithms are widely used. One of the efficient sampling-based path planning algorithms is the Rapidly Exploring Random Tree (RRT). However, the solution provided by RRT is suboptimal. An RRT extension known as RRT* is optimal, but it takes time to converge. To improve the RRT* slow convergence problem, a goal-oriented sampling-based RRT* algorithm known as GS-RRT* is proposed in this paper. The focus of the proposed research work is to reduce unwanted sample exploration and solve the slow convergence problem of RRT* by taking more samples in the vicinity of the goal region. The proposed research work is validated in three different environments with a map size of 384*384 and compared to the existing algorithms: RRT, Goal-directed RRT(G-RRT), RRT*, and Informed-RRT*. The proposed research work is compared with existing algorithms using four metrics: path length, time to find the solution, the number of nodes visited, and the convergence rate. The validation is done in the Gazebo Simulation and on a TurtleBot3 mobile robot using the Robotics Operating System (ROS). The numerical findings show that the proposed research work improves the convergence rate by an average of 33% over RRT* and 27% over Informed RRT*, and the node exploration is 26% better than RRT* and 20% better than Informed RRT*.
Digital Twin Framework for Lathe Tool Condition Monitoring in Machining of Aluminium 5052
Authors: Ganeshkumar S. , Singh Bipin Kumar , Suresh Kumar R. , Haldorai Anandakumar
Published: October 2023

Digital Twin (DT) is a virtual representation of a product system that exhibits the properties and analyzes the system’s functions. The significant impact of DT extends to several fields, which increases productivity and reduces wastage. This article focuses on developing a Digital twin model of a Lathe machine for Tool Condition Monitoring (TCM). DT implementation in industries is challenging due to simulating online cutting forces and wear. Even though several pieces of research have been carried out in the prediction of tool conditions using machine learning, Artificial Neural network models, only a few pieces of research have been made in digital twins for TCM. This article provides the technique for implementing the DT model of a lathe tool. The feasibility of the DT Model framework is verified by a case study of the turning process with a CNC Lathe machine while machining of Aluminium 5052 workpiece using Titanium Nitride coated tool inserts. The sensor’s data are acquired and fed to the microcontroller for real-time data acquisition. The real-time dataset is processed in the DT model for monitoring and predicting the tool conditions. The tool wear classification using the DT model is achieved. Developing the Digital Twin model in machining increases productivity and assists in predictive maintenance.
Poetizando desarraigos
Authors: Camacho López Sandra
Published: October 2023

Abordar el tema del desarraigo desde las prácticas artísticas, tiene múltiples posibilidades. Para esta ocasión, se quiso abordar a través de un taller artístico titulado Poetizando desarraigos dentro del marco del segundo Taller Itinerante de Artes para la Paz (TIAP) de la investigación TransmigrArts. Este taller, tenía como finalidad crear un espacio de expresión a través de juegos escénicos con el cuerpo, el espacio, la imaginación, la voz… que permitieran llegar de manera simbólica y poética a sentimientos y sensaciones de desarraigo. A través de ciertos ejercicios apoyados en nociones teóricas, se buscaba despertar recuerdos, historias y memorias corporales, espaciales, sonoras y objetuales para reconstruir y transformar, desde lo artístico, lo que para las/los participantes pudiese ser la noción de experiencias de desarraigo y aportar de esta manera a uno de los objetivos del TIAP: “incidir en el mejoramiento de los individuos, sus comunidades y territorios.”
Narración gráfica - Laboratorio de investigación creación: índices de un proceso tejido y colaborativo en comunidad
Authors: Pinzón Lizarazo Oscar Daniel
Published: October 2023

Este artículo presenta los antecedentes del proyecto doctoral de investigación creación aplicada que se sustenta en la recuperación de la experiencia vivida y la importancia de esta investigación en el campo de los estudios artísticos. El artículo sintetiza la comprensión de necesidades personales y colectivas que surgen en contextos de trabajo en donde se develan cuestionamientos de ordenes culturales, ambientales y sociales para abordar una práctica situada que permite comprender la migración desde el relato del propio migrante; se indaga en la narración gráfica como posibilidad de trabajar las representaciones propias del migrante a través de la creación de imágenes en lo colectivo a partir de este trabajo se declaran el reconocimiento y establecimiento de demandas en perspectiva bioética.
Tejiendo latidos, ritmos y sonidos de paz
Authors: Villegas Posada José Fernando
Published: October 2023

Esta reflexión surge en el marco proyecto “Rehabilitación y reintegración de niños, jóvenes y adultos traumatizados por la guerra para mejorar la situación social en Colombia 2021- 2023”, implementado por el programa La Paz es una Obra de Arte, en asocio con la Fundación Freunde, Amigos del Arte de Enseñar – Alemania, y con la metodología Pedagogía de Emergencia y Trauma. El proyecto implementó un proceso educativo usando prácticas sociales de las artes con jóvenes de la Comunidad Convivencial de la Escuela de Trabajo San José, de Bello-Antioquia-Colombia.

Este artículo presenta la implementación de los talleres pedagógicos del proyecto en general, con especial énfasis y profundización en la metodología propuesta desde la música. Del módulo “Escucha e Interacción Expresiva”, se expondrán tanto la secuencia didáctica, sus propósitos, intensiones y dispositivos educativos. Además, se muestran los vínculos y relaciones directas entre la música a la construcción de cultura de paz, además de exponer las contribuciones de la música a la paz personal y colectica, percibidas y expresadas por los participantes.
Recovery of Lung Function After 149 Days on Extracorporeal Membrane Oxygenation for COVID-19
Authors: Suero Orlando R. , Valluri Sri Kartik , Farias-Kovac Mario H. , Simpson Leo , Loor Gabriel , Guerra Diana M. , Diaz-Gomez Jose L. , Chatterjee Subhasis
Published: October 2023

This report highlights survival and the patient’s perspective after prolonged venovenous extracorporeal membrane oxygenation (ECMO) for COVID-19–related respiratory failure.

A 36-year-old man with COVID-19 presented with fever, anosmia, and hypoxia. After respiratory deterioration necessitating intubation and lung-protective ventilation, he was referred for ECMO. After 3 days of conventional venovenous ECMO, he required multiple creative cannulation configurations. Adequate sedation and recurrent bradycardia were persistent challenges. After 149 consecutive days of ECMO, he recovered native lung function and was weaned from mechanical ventilation.

This represents the longest-duration ECMO support in a survivor of COVID-19 yet reported. Necessary strategies included unconventional cannulation and flexible anticoagulation.
Short-term biological variation of serum tryptase
Authors: Madsen Anne Tranberg , Kristiansen Helle Pilgaard , Winther-Larsen Anne
Published: October 2023

Objectives

Serum tryptase is a biomarker of mast cell activation. Among others, it is used in the diagnosis of anaphylaxis where a significant increase during the acute phase supports the diagnosis. When evaluating changes in biomarker levels, it is of utmost importance to consider the biological variation of the marker. Therefore, the aim of this study was to evaluate the short-term biological variation of serum tryptase.

Methods

Blood samples were drawn at 9 AM three days in a row from apparently healthy subjects. On day two, additional blood samples were drawn every third hour for 12 h. The tryptase concentration was measured in serum using a fluoroenzyme immunoassay (ImmunoCAP™, Thermo Fisher Scientific). Linear mixed-effects models were used to calculate components of biological variation.

Results

In 32 subjects, the overall mean concentration of tryptase was 4.0 ng/mL (range, 1.3–8.0 ng/mL). The within-subject variation was 3.7 % (95 % confidence interval (CI) 3.0–4.4 %), the between-subject variation was 31.5 % (95 % CI 23.1–39.8 %), and the analytical variation was 3.4 % (95 % CI 2.9–4.1 %). The reference change value was 13.3 % for an increase in tryptase at a 95 % level of significance. No significant day-to-day variation was observed (p=0.77), while a minute decrease in the serum concentration was observed during the day (p<0.0001).

Conclusions

Serum tryptase is a tightly regulated biomarker with very low within-subject variation, no significant day-to-day variation, and only minor semidiurnal variation. In contrast, a considerable between-subject variation exists. This establishes serum tryptase as a well-suited biomarker for monitoring.
Influence of nano chromium addition on the corrosion and erosion–corrosion behavior of cupronickel 70/30 alloy in seawater
Authors: Nattah Ayad Mohammed , Salim Asia Mishaal , Dawood Nawal Mohammed
Published: October 2023

Cupronickel alloys have found widespread use in various applications such as heat exchangers, refrigeration systems, equipment, pumps, and pipes. However, the inherent structure of cupronickel alone may not be able to withstand certain aggressive environments effectively. To address this issue, the mechanical properties and corrosion resistance of cupronickel alloys can be enhanced by carefully selecting the appropriate alloying compositions. The addition of nano chromium (20 nm) has been proposed as a means of designing cupronickel alloys with improved performance. In the present study, corrosion and erosion–corrosion behaviors of cupronickel 70/30 alloys produced by the casting method without and with three different additions of nano Cr (1, 1.2, and 1.5 wt%) were investigated. The prepared specimens were subjected to electrochemical tests in 3.5 wt% sodium chloride solutions to evaluate their corrosion behavior. Additionally, an erosion–corrosion test was conducted at an impact angle of 90°, using a slurry solution containing 1 wt% SiO2 sand in 3.5 wt% NaCl solution as the erodent. The specimens were comprehensively characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction techniques. The surfaces of the alloy specimens exhibited superficial attacks, but no pits were observed. Moreover, the surfaces developed a greenish coloration. The electrochemical tests conducted using saline solution revealed that the corrosivity of the cupronickel alloy with nano chromium addition varied from moderate to low, depending on the selected concentration. Despite undergoing corrosion in the saline environment, the modified cupronickel alloys demonstrated good resistance to this corrosive process. Therefore, they can be considered suitable for use in highly aggressive environments, such as in seawater capture systems. The erosion–corrosion test results indicated that the addition of nano chromium significantly enhanced the resistance of the specimens to erosion–corrosion. At 1.5 wt% Cr, the erosion–corrosion rate was reduced by 99.27%.
On the regularity theory for mixed anisotropic and nonlocal p-Laplace equations and its applications to singular problems
Authors: Garain Prashanta , Kim Wontae , Kinnunen Juha
Published: October 2023

We establish existence results for a class of mixed anisotropic and nonlocal p-Laplace equations with singular nonlinearities. We consider both constant and variable singular exponents. Our argument is based on an approximation method. To this end, we also discuss the necessary regularity properties of weak solutions of the associated non-singular problems. More precisely, we obtain local boundedness of subsolutions, the Harnack inequality for solutions and the weak Harnack inequality for supersolutions.
Effect of refining slag compositions on its melting property and desulphurization
Authors: Li Shisen , Kong Lingzhong , Xu Zhaolong
Published: October 2023

To investigate the feasibility of the refining slag with low fluoride, some oxides such as Al2O3, SiO2, B2O3, and Li2O were used to replace CaF2 in refining slag with the equivalent weight replacement method, and then the melting temperature and desulphurization capacity of slag were determined. The results show that the melting temperature of slag (CaF2 < 4 mass% and Al2O3 > 28 mass%) is less than 1,706 K, when CaF2 is substituted by Al2O3. This slag is able to decrease [S] in steel to less than 0.0060 mass%. In the case of substitution of CaF2 by SiO2, the melting temperature increases, while the desulphurization rate decreases. The fluxing action of B2O3 is stronger than that of CaF2, and the melting temperature decreases to 1,561 K when CaF2 is substituted by B2O3. Li2O can not only lower the melting temperature of slag but also improve the desulphurization rate.
On ℐ2(𝒮θ
p,r

)-summability
of double sequences in neutrosophic normed spaces
Authors: Kumar Vijay , Ganaie Inayat Rasool , Sharma Archana
Published: October 2023

In this article, we aim to define

ℐ
2

⁢

(
𝒮
)

{\mathcal{I}_{2}(\mathcal{S})}

-summability
and

ℐ
2

⁢

(

𝒮

θ

p
,
r

)

{\mathcal{I}_{2}(\mathcal{S}_{{\theta}_{p,r}})}

-summability,
and obtain interesting relationships among these by imposing certain conditions on p and r. Finally, we show that the space

ℐ
2

⁢

(

𝒮

θ

p
,
r

⁢

(
G
,
B
,
Y
)

)

∩

l
∞
2

⁢

(
V
)

\mathcal{I}_{2}(\mathcal{S}_{{\theta}_{p,r}}(G,B,Y))\cap l^{2}_{\infty}(V)

is a closed subspace of

l
∞
2

⁢

(
V
)

{l^{2}_{\infty}(V)}

.
Nondensely defined partial neutral functional integrodifferential equations with infinite delay under the light of integrated resolvent operators
Authors: El Matloub Jaouad , Ezzinbi Khalil
Published: October 2023

In this work, we mainly focus on the local existence and regularity of integral solutions for a class of nondensely defined partial neutral functional integrodifferential equations with unbounded delay. We use the theory of integrated resolvent operators introduced by Oka
[H. Oka,
Integrated resolvent operators,
J. Integral Equations Appl. 7 1995, 2, 193–232].
Finally, we provide an example to demonstrate the basic findings of our work.
Never Say Never: Reproduction of Intergenerational Will and Return of Ideal—Interview with Wang Baoqiang
Authors: Yao Wu , Yirui Cheng
Published: October 2023

Wang Baoqiang is the director of Never Say Never (2023), as well as being a well-known actor. His acting roles include Blind Shaft (Mang jing, 2003), A World Without Thieves (Tianxia wuzei, 2004) and Detective Chinatown series (Tangrenjie tan’an). Following Buddies in India (Danao tianzhu, 2017), Never Say Never is, Wang Baoqiang’s second directorial work: taking six years to hone, the film is a realistic depiction of the story of Xiang Tenghui, a former boxing champion, who is determined to train orphans from China’s remote countryside. Through sports competitions, he aims to provide them with the chance for a better life. This interview is based on the actors’ performances, the director’s audiovisual expression and the pursuit of values; it discusses the film’s reproduction of intergenerational will and the protagonist’s ideal for returning to the middle-aged stage of life, offering an in-depth portrait of the multi-dimensional thinking and artistic insights of Wang Baoqiang, as an experienced actor exploring the path of film directing.
The N221D variant in PCSK1 is highly prevalent in childhood obesity and can influence the metabolic profile
Authors: Guijo Blanca , Argente Jesús , Martos-Moreno Gabriel Ángel
Published: October 2023

Objectives

To study the prevalence and influence on metabolic profile of the prohormone-convertase-1 (PCSK1) N221D variant in childhood obesity, proven its role in the leptin-melanocortin signaling pathway as in proinsulin and other prohormone cleavage.

Methods

Transversal study of 1066 children with obesity (mean age and BMI Z-score 10.38 ± 3.44 years and +4.38 ± 1.77, respectively), 51.4 % males, 54.4 % prepubertal, 71.5 % Caucasians and 20.8 % Latinos. Anthropometric and metabolic features were compared between patients carrying the N221D variant in PCSK1 and patients with no variants found after next generation sequencing analysis of 17 genes (CREBBP, CPE, HTR2C, KSR2, LEP, LEPR,
MAGEL2, MC3R, MC4R, MRAP2, NCOA1, PCSK1, POMC, SH2B1,
SIM1, TBX3 and TUB) involved in the leptin-melanocortin pathway.

Results

No variants were found in 531 patients (49.8 %), while 68 patients carried the PCSK1 N221D variant (42 isolately, and 26 with at least one additional gene variant). Its prevalence was higher in Caucasians vs. Latinos (χ2 7.81; p<0.01). Patients carrying exclusively the PCSK1 N221D variant (n=42) showed lower insulinemia (p<0.05), HOMA index (p<0.05) and area under the curve for insulin in the oral glucose tolerance test (p<0.001) and higher WBISI (p<0.05) than patients with no variants, despite similar obesity severity, age, sex and ethnic distribution.

Conclusions

The N221D variant in PCSK1 is highly prevalent in childhood obesity, influenced by ethnicity. Indirect estimation of insulin resistance, based on insulinemia could be byassed in these patients and underestimate their type 2 diabetes mellitus risk.
Artificial Turf Increases the Physical Demand of Soccer by Heightening Match Running Performance Compared with Natural Grass
Authors: Modric Toni , Esco Michael , Perkovic Sandro , Basic Zlatko , Versic Sime , Morgans Ryland , Sekulic Damir
Published: October 2023

Modric, T, Esco, M, Perkovic, S, Basic, Z, Versic, S, Morgans, R, and Sekulic, D. Artificial turf increases the physical demand of soccer by heightening match running performance compared with natural grass.J Strength Cond Res37(11): 2222–2228, 2023—This study aimed to determine differences in match running performance (MRP) of elite soccer players (n= 31) during matches played on artificial turf (AT) and natural grass (NG). The players' MRP (AT; 131 observations, NG; 135 observations) were collected during official matches (n= 32) using global positioning system and classified according to their playing positions as central defenders, central midfielders, fullbacks, forwards, and wingers. The MRP variables included total distance covered (TD), low-intensity running (LIR), moderate-intensity running (MIR), high-intensity running (HIR), total (Tacc) and high-intensity accelerations (Hacc), and total (Tdec) and high-intensity decelerations (Hdec). The influence of match outcome, location, and opponent quality was controlled for as contextual factors. Playing matches on AT resulted in (a) increased TD (Cohen'sd(d) = 0.55, 0.61, and 0.28, respectively), MIR (d= 0.91, 0.79, and 0.49, respectively), and HIR (d= 0.67, 0.44, and 0.38, respectively) for central defenders, central midfielders, fullbacks; (b) increased Tacc (d= 0.38, 0.37, and 0.4, respectively) and Tdec (d= 0.31, 0.34, and 0.31, respectively) for central defenders, central midfielders, and wingers; and (c) decreased Hdec (d= −1.5) for forwards. These results show that playing on AT is more physically demanding for defensive and midfield players than playing on NG. Soccer coaches should consider implementing preparatory strategies that mitigate the increased demands of playing on AT for these players, especially before a competitive period when transitions between pitch surfaces routinely occur.