bluuebunny/crossref_metadata_2025 huggingface dataset:
ORIGENS DA IDEIA DE LIBERDADE NO OCIDENTE
Authors: De Oliveira Lima Newton , Nogueira Santos Lirton
Published: November 2024

O liberalismo como conjunto doutrinário não é só um fenômeno moderno, ele tem bases e antecedentes na Antiguidade, com o humanismo estóicos e sofistas e reaparece na modernidade após o personalismo cristão, que fortaleceu e ampliou a estrutura da individualidade, encontrando na filosofia de Immanuel Kant sua síntese doutrinária e perspectiva de conservação da liberdade nos elementos morais e políticos eficazes de reforma do Estado e defesa da dignidade humana calcada na vontade do indivíduo, pois Kant foi um liberal republicano, defensor da ciência moderna e do iluminismo contrário ao absolutismo. Kant apregoa a incondicionalidade da vontade no seu livre querer da lei moral, que resume a liberdade Ocidental em sua matriz mais relevante de valor moral e político como projeto juspolítico.
BUSINESS INTELLIGENCE E O DIREITO À PRIVACIDADE
Authors: Santos Jorge Fabricio dos , Santos Junior Cláudio Fernando de Souza , Reis Netto Roberto Magno
Published: November 2024

O uso do Business Intelligence (Inteligência empresarial) pelas organizações privadas carece de informações sobre o mercado para ofertar bens e serviços que atendam às suas demandas, utilizando-se de dados pessoais de seus consumidores, o que pode acarretar riscos à Segurança da Informação e a privacidade de seus clientes. Desta maneira, este artigo tem por finalidade demonstrar as normas jurídicas, técnicas e teóricas que apoiem a aplicação do Business Intelligence e Segurança da Informação no gerenciamento de informações pessoais de consumidores em instituições comerciais privadas. Foi adotada uma pesquisa aplicada, qualitativa, de cunho exploratório e descritiva, com uso de dados documentais e bibliográficos, com tratamento pela técnica de Análise para a apresentação dos resultados. Os resultados principais evidenciam que a prática do Business Intelligence requer a aplicação da metodologia da segurança da informação sobre os dados pessoais dos consumidores, a fim de protegê-los e atender aos requisitos constitucionais do Direito à Privacidade, pois há riscos de comercialização ilícita desses dados privados, bem com vazamentos para uso ilegítimo, podendo tais organizações serem responsabilizadas civilmente. Assim, propõem-se a adoção de procedimentos de segurança da informação, modificação dos sistemas das organizações para proteger esses dados, além da constante ciência dos consumidores para autorizações do uso de seus dados, além de novas pesquisas sobre o tema apresentado.
Palavras-chave: Inteligência empresarial. Dados pessoais. Consumidores. Riscos.
Corrigendum to: A Multimodal Ultrasound Observation Study on the Effect of Vitamin D on Uterine Fibroids in Non-menopausal Women
Authors: Wang Qi , Tian Peng , Sun Wei , Liu Xin , Yang Xiuhua , Yang Zhiwei
Published: November 2024

In the online version of the article entitled “A Multimodal
Ultrasound Observation Study on the Effect of Vitamin D on
Uterine Fibroids in Non-menopausal Women”, a change was
made in the funding section by the author, Xiuhua Yang, in the
journal “Current Medical Imaging Reviews”, 2024; 20:
e15734056281479 [1].

The original article can be found online at:
https://www.benthamscience.com/article/135748

Original:

FUNDING

No funding was available for this study.

Corrected:

FUNDING

This study is funded by the scientific research project of
Heilongjiang Provincial Health Commission (project
number:20220909021015).
Gonolobus imladrisanthus (Apocynaceae, Asclepiadoideae), una especie nueva de frutos comestibles de Durango, México
Authors: Pío-León Juan Fernando , Gutiérrez-Sánchez Rodolfo Maximiliano , Alvarado-Cárdenas Leonardo O.
Published: November 2024

Antecedentes y Objetivos: La revisión rutinaria de la plataforma iNaturalistMX en 2023 permitió detectar el registro de un individuo de Gonolobus que correspondía a una ecorregión no conocida para este género. Exploraciones posteriores permitieron ubicar diferentes poblaciones de Gonolobus con corola blanca, rasgo poco común en el género. La morfología distintiva y localidad de las plantas colectadas sugiere que se trata de una nueva especie, la cual se describe y compara con el resto de las especies de corolas blancas conocidas.
Métodos: Se realizaron exploraciones y colectas botánicas alrededor de la comunidad Santiago Bayacora, Durango, México, y los ejemplares se analizaron en el herbario CIIDIR. La identidad de la especie se determinó mediante revisión de literatura, ejemplares de herbario y registros fotográficos en iNaturalistMX. Se elaboró un mapa de distribución, láminas comparativas y una clave de identificación para las especies de Gonolobus con corolas blancas. Su estado de conservación se propuso de acuerdo con los criterios de la IUCN.
Resultados clave: Gonolobus imladrisanthus es solo conocida de las cañadas de la serranía de Santiago Bayacora, Durango, México, que se localiza en la ecorregión xerófila de la Sierra Madre Occidental. Es morfológicamente afín a G. edulis (endémica de Costa Rica y Panamá) y G. exannulatus (endémica de Chiapas y Guatemala), de las que se diferencia por sus apéndices dorsales bilobados y ascendentes. Los pobladores de Santiago Bayacora reportaron consumir sus frutos hervidos en leche. Se evalúa provisionalmente a G. imladrisanthus como especie Vulnerable (VU).
Conclusiones: Este nuevo taxon es la quinta especie conocida del género en el estado de Durango y la primera que ocurre en su vegetación xerófila. Se consolida a México como uno de sus principales centros de diversidad y aporta también a su patrimonio biocultural al describir una especie nueva con importancia alimenticia.
The mediating effect of green culture on the relationship between GHRM and green sustainable performance in Jordanian SME logistics companies
Authors:   Department of Human Resources Management, Faculty of Business, Jadara University, Irbid, Jordan, Aloqaily Ahmad Nader , Qawasmeh Esraa Farid ,   Department of Human Resources Management, Faculty of Business, Jadara University, Irbid, Jordan, Masa'd Fawzieh Mohammed ,   Department of Human Resources Management, Faculty of Business, Jadara University, Irbid, Jordan, Alrousan Ahmad ,   Department of Human Resources Management, Faculty of Business, Jadara University, Irbid, Jordan, Al-Zaqeba Murad Ali Ahmad ,   Faculty of Economics and Muamalat (FEM), Universiti Sains Islam Malaysia (USIM), Nilai, Negeri Sembilan, Malaysia
Published: November 2024

The paper aims to explore the mediating effect of green culture (GC) on the relationship between Green Human Resource Management (GHRM) and Green Sustainable Performance (GSP) in small and medium logistics companies in Jordan. With increasing attention to environmental issues and sustainability becoming crucial for the future of the logistics sector, GHRM practices are gaining importance in enhancing sustainable performance. This study focuses on how promoting GC within organizations can strengthen the effectiveness of GHRM initiatives to achieve better sustainable outcomes. A quantitative research method was used to gather data from SME logistics companies in Jordan through structured questionnaires. Data analysis was conducted using SPSS-29 and Smart PLS4. The results show that GHRM practices have a significant positive impact on GSP in Jordanian SME logistics companies. Key components of GHRM, such as green recruitment and selection, green training and development, and green reward and compensation, were found to be strong predictors of GSP. Furthermore, GC was identified as a mediator between GHRM practices and GSP, showing that GHRM practices contribute to the development of a GC in these organizations. The findings also reveal that a strong GC fully mediates the relationship between GHRM practices and sustainable performance, emphasizing the importance of cultivating a robust GC to enhance the positive effects of GHRM on organizational sustainability. These results provide insights for addressing gaps in sustainable practices within the logistics sector and offer recommendations for managers looking to implement green initiatives in their companies.
Assessing the Quality of an Online Democratic Deliberation on COVID-19 Pandemic Triage Protocols for Access to Critical Care in an Extreme Pandemic Context: Mixed Methods Study (Preprint)
Authors: Calderon Ramirez Claudia Lucrecia , Farmer Yanick , Downar James , Frolic Andrea , Opatrny Lucie , Poirier Diane , Bravo Gina , L'Espérance Audrey , Gaucher Nathalie , Payot Antoine , Dahine Joseph , Tanuseputro Peter , Rousseau Louis-Martin , Dumez Vincent , Descôteaux Annie , Dallaire Clara , Laporte Karell , Bouthillier Marie-Eve
Published: November 2024

BACKGROUND

Online democratic deliberation (ODD) may foster public engagement in new health strategies by providing opportunities for knowledge exchange between experts, policy makers, and the public. It can favor decision-making by generating new points of view and solutions to existing problems. Deliberation experts recommend gathering feedback from participants to optimize future implementation. However, this online modality has not been frequently evaluated.

OBJECTIVE

This study aims to (1) assess the quality of an ODD held in Quebec and Ontario, Canada, on the topic of COVID-19 triage protocols for access to critical care in an extreme pandemic context and (2) determine its transformative aspect according to the perceptions of participants.

METHODS

We conducted a simultaneous ODD in Quebec and Ontario on May 28 and June 4, 2022, with a diversified target audience not working in the health care system. We used a thematic analysis for the transcripts of the deliberation and the written comments of the participants related to the quality of the process. Participants responded to a postdeliberation questionnaire to assess the quality of the ODD and identify changes in their perspectives on COVID-19 pandemic triage protocols after the deliberation exercise. Descriptive statistics were used. An index was calculated to determine equality of participation.

RESULTS

The ODD involved 47 diverse participants from the public (n=20, 43% from Quebec and n=27, 57% from Ontario). Five themes emerged: (1) process appreciation, (2) learning experience, (3) reflecting on the common good, (4) technological aspects, and (5) transformative aspects. A total of 46 participants responded to the questionnaire. Participants considered the quality of the ODD satisfactory in terms of process, information shared, reasoning, and videoconferencing. A total of 4 (80%) of 5 participants reported at least 1 change of perspective on some of the criteria and values discussed. Most participants reported that the online modality was accessible and user-friendly. We found low polarization when calculating equal participation. Improvements identified were measures to replace participants when unable to connect and optimization of time during discussions.

CONCLUSIONS

Overall, the participants perceived the quality of ODD as satisfactory. Some participants self-reported a change of opinion after deliberation. The online modality may be an acceptable alternative for democratic deliberation but with some organizational adaptations.
Enhancing Neoadjuvant Therapy Efficacy in Triple-Negative Breast Cancer: A Research Protocol (Preprint)
Authors: Sood Karan , Tyagi Pratiksha , Dongre Amol
Published: November 2024

BACKGROUND

Triple-negative breast cancer (TNBC) is a highly malignant subtype of breast cancer characterized by the absence of estrogen, progesterone, and HER2/neu receptors. It is often associated with poor prognosis, high recurrence rates, and limited treatment options. Neoadjuvant chemotherapy (NACT) has been a cornerstone in the management of TNBC, yet the addition of carboplatin-a platinum-based agent-has shown promise in enhancing pathological complete response (pCR) rates and event-free survival (EFS) in various studies.

OBJECTIVE

• To assess event free survival in patients receiving carboplatin in addition to standard chemotherapy.
• To determine the pathological complete response after neoadjuvant chemotherapy

METHODS

This study aims to evaluate the efficacy of incorporating carboplatin into standard NACT regimens for TNBC, focusing on its impact on pCR rates and DFS among patients in a rural setting in central India. This prospective observational study will include 39 patients diagnosed with stage II and III non-metastatic TNBC. Participants will receive a regimen of Adriamycin and cyclophosphamide followed by Paclitaxel and carboplatin. The study will assess pCR rates and DFS. Patients will be monitored for clinical and radiological responses, with evaluations performed using RECIST criteria. This study will provide valuable insights into the role of carboplatin in enhancing the efficacy of NACT for TNBC.

RESULTS

This study is poised to make a substantial contribution to the current body of knowledge concerning the management of triple negative breast cancer by enhancing the neoadjuvant therapy. This is an ongoing study protocol, and the results are going to be collected and analyzed in mid 2025.

CONCLUSIONS

Our study aims to treat patients with TNBC in a rural central Indian tertiary care hospital by starting with AC regimen followed by Paclitaxel and carboplatin as a neoadjuvant treatment. This study will help in representing this specific demographic population for early therapy enhancement and getting better survival in this subset of breast cancer.

By employing a rigorous methodology, we strive to provide robust evidence on which intervention will offer superior outcomes in terms of pathological complete response and disease free interval. The findings from this trial are expected to inform clinical practice by guiding healthcare providers in selecting the most effective therapeutic approach for managing triple negative breast cancer, potentially improving patient outcomes in this patient population.

CLINICALTRIAL

Trial Registration

Clinical Trials Registry of India CTRI/2023/11/059751
https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=OTUwODc=&Enc=68268.24470&userName=059751
The feasibility of a co-designed Virtual Reality experience in those with chronic low back pain (Preprint)
Authors: Shorter Kathleen Anne , Benson Amanda C , Brown Alyse C , Tissera Kevin , Zwack Clara C , Fluke Christopher , Vincs Kim , Lambert Gavin , McDonald Rachael L
Published: November 2024

BACKGROUND

Low back pain has been identified by the World Health Organisation as the leading cause of disability globally, with 4 to 25% progressing to a presentation of chronic low back pain (CLBP). Exercise based therapy is advocated for those with CLBP, with the use of virtual reality (VR) a potential modality to address poor adherence.

OBJECTIVE

The purpose of this study, using surface electromyography (sEMG), was to understand the feasibility of co-designed bespoke VR experiences to elicit muscle activity within those with CLBP.

METHODS

Using a cross-sectional descriptive study design, CLBP sufferers (n=14) underwent three of five co-designed, bespoke VR experiences with muscle activity quantified using surface electromyography of muscles of the lower back.

RESULTS

Muscles were observed to be active for 52.9 ± 29.8% of the duration of the VR experiences at a very low intensity of exercise with a significant interaction (F(12)=2.207, p=0.011) effect between VR experience and muscles activated observed.

CONCLUSIONS

This investigation established the feasibility of co-designed VR experiences to elicit muscle activity at very low levels of intensity for those with CLBP. Variation in muscle activity between muscles and VR experiences demonstrates how the modality may need to be tailored through the professional oversight to ensure the desired range of motion and specific muscle activity is elicited.
A Co-designed Digital Device for Tracking Rehabilitation Dosage After Stroke: Validity and Feasibility Study in a Clinical Environment (Preprint)
Authors: Boyd Fiona , Sweeney Gillian , Barber Mark , Forrest Elaine , Dunlop Mark , Kerr Andrew
Published: November 2024

BACKGROUND

In 2023, the National Clinical Guidelines for Stroke revised the recommended daily multidisciplinary therapy dose from 45 minutes to 3 hours. To monitor the achievement of these guidelines there is a need for accurate measurement. This study introduces a novel co-designed digital dosage tracking system that utilises Near Field Communication (NFC) technology to log rehabilitation activities and demonstrates its feasibility and accuracy in a clinical setting through comparison with the current clinical method of manual recording.

OBJECTIVE

This study aimed to assess the validity, feasibility, and usability of a novel co-designed digital tracker using Near Field Communication (NFC) technology to automatically log rehabilitation dosage in stroke patients, providing an objective and low-burden solution for clinical environments.

METHODS

This pilot mixed-methods study included two phases. Phase 1 involved a usability trial with nine participants conducted at a university research centre, assessing usability with the System Usability Scale (SUS) and Intrinsic Motivation Inventory (IMI). Phase 2 consisted of a clinical trial in an NHS stroke ward with 15 inpatients, comparing the digital tracker with manual therapist recordings for validity and feasibility using paired t-tests, Cohen's D, and Bland-Altman plots. An acceptable discrepancy range was set at ±5-10%.

RESULTS

The digital tracker demonstrated high usability with a mean SUS score of 91.43 (SD = 9.53) and strong user satisfaction (IMI score 6.29/7, SD = 1.50). Clinical trial results showed a strong agreement between the digital and manual methods (t(207)=-1.55, P=.12, Cohen’s D=-0.06), with a small mean time discrepancy of 1.18 minutes (SD = 10.98) across 208 activities. The Bland-Altman plot indicated good accuracy and consistency between methods, with limits of agreement within the clinically acceptable range.

CONCLUSIONS

The co-designed digital tracker has been shown to agree with a manual method for recording rehabilitation dosage. This development presents the opportunity for objective, automated and low-burden recording of rehabilitation dose to support prescription, monitoring and research.

CLINICALTRIAL

ClinicalTrials.gov: NCT05981729
IRAS ID No. 329156
Chemogenetic manipulation of the ventral pallidum-nucleus accumbens shell pathway modulates sucrose consumption independent of motivation in female rats. (Preprint)
Authors: Peroutka Markie , Covelo Ignacio Rivero
Published: November 2024

UNSTRUCTURED

Here we investigated the role of the ventral pallidum (VP) to nucleus accumbens shell (AcbSh) pathway in mediating sucrose consumption and motivation for food in female rats. Using chemogenetic techniques, excitatory and inhibitory designer receptors were expressed in VP neurons projecting to the AcbSh. Behavioral assays assessed both lever pressing under a progressive ratio schedule and free sucrose consumption following activation or inhibition of this pathway. Results showed that inhibition of VP-AcbSh projections increased sucrose intake, while excitation reduced it, without affecting motivation to work for food. These findings indicate a specific influence of the VP-AcbSh pathway on sucrose consumption independent of food-seeking motivation. The study highlights the importance of differentiating VP efferents in understanding distinct roles in feeding behaviors and suggests that the VP-AcbSh pathway modulates consumption based on food type and potentially other variables.
PREPARATION, CHARACTERIZATION, AND IN VITRO EVALUATION OF GEL CONTAINING NANOPHYTO-PHOSPHOLIPID COMPLEX OF KOPASANDA LEAF EXTRACT (CHROMOLAENA ODORATA (L.) R. M. KING AND H. ROB)
Authors: RIDWAN SUCILAWATY , WAHYUNI NURUL , PASARIBU GUNAWAN , SAFWAN SAFWAN , HAJRIN WAHIDA , FITRIANA MARIAMA , ROIYAN KAMELIA
Published: November 2024

Objective: This study aims to prepare, characterize, and in vitro evaluation of the gel containing nanophyto-phospholipid complex of kopasanda leaf extract.
Methods: Kopasanda dried leaf was extracted by extraction reflux method, followed by total phenolic content of extract measurement using Spectrophotometry UV-Vis method. The nanophyto-phospholipid complex was prepared using an antisolvent evaporation method with various ratios between extract and phospholipid of 1:1; 1:2; 1:3. The optimum ratio was evaluated by entrapment efficiency (%). The nanophyto-phospholipid complex formation was characterized by polydispersity index, particle size, Fourier Transform Infra-Red (FT-IR), and the Transmission Electron Microscope (TEM) method. The optimum nanophyto-phospholipid complex was formulated into gel preparation. The in vitro permeation study was performed to discover the influence of gel containing nanophyto-phospholipid complex compared with gel-containing extract without the nanophyto-phospholipid complex formation.
Results: Thetotal phenolic content of kopasanda leaf extract was 117.214±3.054 mg/GAE. The optimum ratio of kopasanda leaf extract and phospholipid was 1: 2 with entrapment efficiency (%), particle size, and polydispersity index equal to 99.897±0.001%, 130.1 nm and 0.394. The morphology of the nanophyto-phospholipid complex was spherical and the complex formation was confirmed by the FTIR spectrum. The permeation test showed that the gel containing nanophyto-phospholipid complex had better diffusion than the gel without the nanophyto-phospholipid complex formation.
Conclusion: The gel containing nanophyto-phospholipid complex formation exhibited the potential drug delivery system to increase the phenolic content permeation of kopasanda leaf extract.
THERAPEUTIC USE OF ALPHA-LIPOIC ACID SUPPLEMENTATION: A REVIEW ON CURRENT USE AND FUTURE PROSPECTIVE
Authors: TAHA MURTADA
Published: November 2024

Alpha-lipoic acid (ALA, thioctic acid, 5-(1,2-dithiolan-3-yl) pentanoic acid) is an organosulfur compound produced by plants, humans, and animals. ALA plays a crucial role in mitochondrial bioenergetics reactions. It is a natural antioxidant and a dithiol compound. ALA is a coenzyme that plays a crucial role in the function of pyruvate and Alpha-ketoglutarate dehydrogenase complexes found in mitochondria. ALA has cytotoxic and antiproliferative effects on several cancers, including Polycystic Ovarian Syndrome (PCOS). Most of ALA's clinical applications come from its antioxidant properties, but it also shows potential in treating female and male infertility. Although ALA can potentially be a therapeutic agent, its pharmacokinetic profile limits its effectiveness. Research suggests that ALA has a short half-life and low bioavailability (around 30%) because it gets broken down in the liver, has reduced solubility, and is unstable in the stomach. Liquid formulations have higher bioavailability and plasma concentration than solid dose forms. This review covers the current clinical evidence on using ALA to prevent, manage, and cure numerous disorders, including diabetic neuropathy, obesity, central nervous system-related ailments, and pregnancy abnormalities.
DEVELOPMENT, OPTIMIZATION AND ASSESSMENT OF NAPROXEN MICROSPONGES BY BOX-BEHNKEN DESIGN AS A TARGETTED AND CONTROLLED RELEASE DRUG DELIVERY
Authors: GUPTA SONIA , GUPTA JYOTI
Published: November 2024

Objective: Due to weak physical, chemical stability and poor bioavailability of Naproxen conventional dosage form; the purpose of this work is to improve formulation stability, additionally to accomplish highest possible concentration of the drug in the blood by preparing Naproxen loaded microsponges.
Methods: Naproxen Microsponge (NM) was created utilising the quasi emulsion technique. In this process Ethyl Cellulose (EC) acts as a polymer, Poly Vinyl Alcohol (PVA) acts as the emulsifier, and Dichloromethane acts as the solvent. To investigate how changes in different formulation and processing parameters affect important product qualities, a Box Behnken Design (BBD) was used. Particle Size, Percentage Yield, and Entrapment Efficiency (%EE) were selected as response factors, whereas independent variables including EC quantity (X1), PVA concentration (X2), and Stirring Speed (X3) were selected as independent variables.
Results: The microsponges underwent thorough analysis using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Diffraction (XRD), and Particle Size analysis. The evaluation included studying the morphology, drug loading, and in vitro drug release. The compatibility studies showed no chemical interactions between the drug and the polymers used. It was observed that the ratio of drug to polymer had a significant impact on drug content, EE and particle size. The SEM results revealed that the microsponges were spherical with a porous surface and had a mean particle size of 15.15 µm. The in vitro drug release studies demonstrated that the optimized Naproxen Microsponge Formulation (NMF2) achieved over 80% extended drug release by the end of 8 h, following the Corsmeyer Peppas Model.
Conclusion: The Naproxen loaded microspheres possessed a sustained release with improved bioavailability and better stability.
TRANSETHOSOMES FOR ENHANCED TRANSDERMAL DELIVERY OF METHOTREXATE AGAINST RHEUMATOID ARTHRITIS: FORMULATION, OPTIMISATION AND CHARACTERISATION
Authors: PRATIKSHA N. POOJARI , PRIYA SNEH , SANJANA  , KHANDIGE PRASANNA SHAMA
Published: November 2024

Objective: The study aimed to develop and optimise Methotrexate (MTX)-loaded Transethosomal Film-Forming Gel (TE FFG) for transdermal delivery to treat rheumatoid arthritis while alleviating the side associated with oral administration.
Methods: The Transethosomes (TE) were prepared using the thin film hydration technique and incorporated into an FFG using chitosan. The Box-Behnken Design method was used to analyse the influence of independent variables such as the concentration of soya lecithin, surfactant, and ethanol on parameters including vesicle size, PDI (Polydispersity Index), zeta potential, and entrapment efficiency. The optimised transethosomal suspension was incorporated into the FFG using 3% chitosan and other excipients. In vitro drug release and ex vivo skin permeation of FFG were performed using Franz diffusion cells.
Results: The vesicle size, PDI, zeta potential and entrapment efficiency of the optimised formulation of TE were 110.3 nm, 0.352,-14.4 mV and 49.36%, respectively. The Transmission Electron Microscopy (TEM) image showed that the vesicles were uniform and spherical. The in vitro drug release study was higher for Conventional (CL) FFG) than TE FFG and the drug release mechanism was fitted into the Higuchi model. The permeation was higher for TE FFG, with the steady-state flux being 1.55 times greater than the CL FFG. The skin irritation test on Wistar rats revealed no indication of irritation on the skin. The histopathology examination showed a significant reduction in the inflammatory cells in the treated group.
Conclusion: Therefore, the results concluded that the formulated MTX-loaded TE FFG could be a potentially promising substitute for the oral delivery of methotrexate
DEVELOPMENT AND EVALUATION OF CYCLODEXTRIN NANOSPONGES-BASED TOPICAL FORMULATION OF TAZAROTENE
Authors: PRATAP RAVINDRA , LANKALAPALLI SRINIVAS
Published: November 2024

Objective: Tazarotene is used as a topical retinoid for the treatment of acne, psoriasis and sun-damaged skin. But its topical formulation has many side effects, including itching, burning, dryness, redness, stinging, rash blistering, skin discoloration, peeling at the site of application and low bioavailability. The present study focuses on the reduction of side effects and enhancement of solubility and topical bioavailability of tazarotene by using cyclodextrin-based nanosponges.
Methods: Nanosponge of tazarotene were prepared by lyophilization method. The physiochemical characterization of plain nanosponges and drug-loaded nanosponges were performed using Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and X-ray Diffractometer (XRD) studies. The drug-loaded nanosponges were incorporated into a carpool-based gel formulation. The prepared formulation was evaluated for viscosity, dissolution and stability. FTIR, DSC and XRD studies confirmed the formation of inclusion complex of tazarotene with nanosponges.
Results: The particle size of the drug-loaded nanosponges was found to be in the range of 156.72 to 163.48 nm. Transmission Electron Microscopy (TEM) images revealed the regular spherical shape of both the nanosponges that are unaffected even after drug encapsulation. The pH of the gel formulations was found to be in the range of 5.86 to 6.46. The gel formulation resulted in the diffusion of drug in controlled manner for up to 24 h. The in vitro dissolution studies revealed that nanosponges-based topical formulation had better results than the marketed product.
Conclusion: Thus, the study showed that nanosponge-based gel formulation can be a possible alternative to conventional formulations of tazarotene with enhanced bioavailability and skin retention characteristics for topical application.
NOVEL HYBRIDS OF QUINOLINE LINKED PYRIMIDINE DERIVATIVES AS CYCLOOXYGENASE INHIBITORS: MOLECULAR DOCKING, ADMET STUDY, AND MD SIMULATION
Authors: K DEEPTHI , KATAGI MANJUNATH S. , FERNANDES JENNIFER , DIXIT SHESHAGIRI , SINGH DEEPSHIKHA
Published: November 2024

Objective: Finding novel anti-inflammatory compounds is a crucial sector of research despite the significant advances this field has made. Inefficiency and unfavorable side effects are indeed potential drawbacks of conventional therapy utilizing steroidal or nonsteroidal drugs. This study aims to screen the designed quinoline-linked pyrimidine derivatives as Cyclooxygenase (COX) inhibitors.
Methods: In the present study, we assessed the binding interactions of designed quinoline-linked pyrimidine derivatives with COX enzymes using a molecular docking approach. Using Molecular Dynamics (MD) simulations, the compound’s behavior was further investigated and its stability and conformational dynamics were demonstrated. Schrödinger's QikProp program was utilized to analyze the Absorption, Distribution, Metabolism, and Excretion (ADME) properties and toxicity properties were further investigated using Osiris Property Explorer. Additionally, the protein-ligand complexes' binding free energy has been ascertained using the Molecular Mechanics/Generalized Born Surface Area (MM-GBSA) approach, which offered crucial information regarding the strength of their interactions.
Results: The designed quinoline-linked pyrimidine derivatives fulfilled the Lipinski Rule of Five and had physicochemical characteristics within acceptable ranges, better ADME properties, and were non-toxic. Among the designed compounds, QPDU1 and QPDT6 showed correspondingly good docking scores for COX-1 and COX-2. QPDT6 was additionally analyzed by MD simulation studies to thoroughly examine the interaction between protein and ligand and their stability.
Conclusion: The proposed compounds exhibit strong binding affinities to COX enzymes, stable interactions in MD simulations, and favorable drug-like features. These results support the need for more research and development of these substances as possible anti-inflammatory drugs.
SAMBILOTO LEAF NANOEMULSION AS A PHOTOPROTECTIVE AGENT: OPTIMIZATION OF TWEEN 20 AND PEG-400 CONCENTRATION USING THE REGULAR TWO-LEVEL FACTORIAL DESIGN
Authors: APRIANI ELSA FITRIA , MIKSUSANTI MIKSUSANTI , AGUSTIARINI VITRI , FRANSISKA OCHITA LEDY , HARDESTYARIKI DWI
Published: November 2024

Objective: This study aims to determine the optimum concentration of Tween 20 and Polyethylene Glycol 400 (PEG-400) in Sambiloto leaf extract nanoemulsion.
Methods: The formula of sambiloto leaf nanoemulsion was developed using the regular two-level factorial design based on responses of pH values, density, viscosity, and transmittance percentage. The optimum formula was tested for stability and photoprotective activity by determining the Sun Protection Factor (SPF) value and antioxidant activity.
Results: Sambiloto leaf extract contains andrographolide at 3.397%. The optimum formula for nanoemulsion preparations was obtained at 10% of tween 20 and 10% of PEG-400. The optimum nanoemulsion had a distinctive green extract aroma, a transmittance percentage of 86.7±0.170, a globule size of 130.43±54.056 nm, a polydispersity index of 0.318±0.043, and a zeta potential of-26.5±0.544 mV. The optimum formula's photoprotective activity resulted in an SPF value of 42.944±0.026 and an IC50 of 103.611±1.085 ppm. There was no significant change in pH or transmittance percentage based on the stability test (p<0.05).
Conclusion: The results show that the optimum formula of sambiloto leaf nanoemulsion could be a photoprotective agent that is also stable.
SYNERGISTIC EFFECT LUNG CANCER THERAPY: CO-DELIVERY OF QUERCETIN AND CISPLATIN VIA EUDRAGIT L-100 NANOPARTICLES IN VITRO
Authors: AL-MAMOORI FIRAS F. , WAHAB HABIBAH A. , AHMAD WAQAS
Published: November 2024

Objective: This study aims to investigate the potential of Eudragit L-100 nanoparticles for the co-delivery of quercetin and cisplatin to lung cancer cells, seeking to exploit the synergistic effects of the two drugs while overcoming their individual limitations.
Methods: We investigate the synergistic effect of co-delivering quercetin and cisplatin using Eudragit L-100 nanoparticles for lung cancer therapy. The nanoparticles were synthesized using the nanoprecipitation method, where Eudragit L-100 was dissolved in an organic solvent, followed by the incorporation of quercetin and cisplatin. The resultant nanoparticles were characterized for size, zeta potential, drug loading efficiency, and morphology using techniques such as Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM).
Results: The co-loaded Quercetin-Cisplatin Nanoparticles (Qu-Cis)-NPs formulation had a mean particle size of 475±4.77 nm. Polydispersion index of 0.266±0.093 and zeta potential was-24.03±0.89 mV. The in vitro cytotoxicity was assessed using normal cell and lung cancer cell lines in vitro studies showed that the developed nanoparticles significantly increased cancer cell mortality compared to individual drug treatments. The combination (Qu-Cis)-NPs showed more cytotoxicity on the Non-Small Lung Cancer Cell Line (NCI-H460) cancer cell line after 48 h of incubation compared to Qu loaded-NPs and Cis loaded-NPs, particularly at a concentration of 1 mg/ml. The combination showed no cytotoxicity effect on normal Human Lung fibroblast cell Lines (CCD-19 lu) cells at all concentrations after 24 h, but showed cytotoxicity effects at concentrations (0.125, 0.25, 0.5, and 1.0) mg/ml after 48 h.
Conclusion: The Eudragit L-100 nanoparticle system for co-delivering quercetin and cisplatin showed a promising synergistic effect in lung cancer treatment. It effectively addresses the solubility and toxicity issues of both drugs, offering a potentially more effective treatment option that merits further clinical investigation.
Artificial Intelligence (AI): A Review of Its Uses and Impacts in English Language Teaching and Learning
Authors: Choudhury Rahim Uddin , Hossain Md. Mokbul , Mohamed Mohamed Elboussairi Salih Elhaj , Talukdar Mohammad Mazedul Huq
Published: November 2024

Artificial Intelligence (AI) refers to the imitation of human thought processes by a computer system to behave in a human-like manner. As a key factor of the Fourth Industrial Revolution, AI is transforming education by facilitating more accessible and customized learning experiences. To explore the cause of the rising integration of AI in education, this article analyses the latest literature and AI tools employed in the industry to comprehend the role of AI in English language teaching and learning. This study uses a qualitative research method to collect and analyse fifty citable, recently published scholarly writings available at the Google Scholar database. The data is synthesized and examined through content analysis techniques to summarize and integrate key information for precise and accurate results. The results suggest that AI fosters a supportive environment, provides rich materials according to the learner's proficiency, career goals, and personal interests, significantly upgrading the teaching and learning experience in ELT. Despite its limitations and challenges, the role of AI in education is going to expand with the development of technology offering even more innovative approaches and tools to enhance both teaching practices and learning outcomes in the field of English language education.
Humanitarian Perspectives and Materialism in Sudha Murty’s Dollar Bahu and House of Cards
Authors: Aayushi Aayushi , Kamboj Dr. Sonam
Published: November 2024

On the contrary to the humanitarian values presented in Sudha Murty's works, novels like "Dollar Bahu" and "House of Cards" emphasize their difference with materialism. Firstly, in "Dollar Bahu", a choice has to be made between her enjoyment in India or seeking wealth in the US and thus portrays Western materialism. Lastly, in "House of Cards", the weak-minded greed and materialism lead to the compromising of morals and relationships and, therefore, call out more for compassion. The present research paper explores the cosmopolitan sensibility and global humanitarian perspectives present in some selected novels by Sudha Murty, such as Dollar Bahu and House of Cards. Using a description, interpretative, and analytic approach with library research, the paper critiques Murty's views concerning materialism, the deterioration of moral values, and regaining human morals. The analytical overview emphasizes important humanitarian themes represented by characters and love stories, selflessness, responsibility, and ethical values. Murty's writings can be viewed in the light of reflection about how materialism clashes with moral values in today's society and the need to return to humanitarian ideals in this globalized world.
Engaging English Language Learners through Gamification and Serious Games
Authors: Aayushi Aayushi , Kamboj Dr. Sonam
Published: November 2024

This project investigates the creative blending of gamification and serious games in a way that encourages ELL engagement in the classroom. Such a belief exists that teachers can create a good learning environment that fosters the acquisition of language, as well as the active engagement of pupils, by tapping into elements of game design to foster community among learners. The current study provides a taxonomy of the key benefits and drawbacks in applying serious games and gamification for teaching English. By considering the SWOT analysis of the application of the two singular, game-based approaches to learning a language like English, student opinions are gathered by using the Delphi method. This study produced an ordered list of critical adoption and entry factors to consider while gamifying the process of learning English. Discussion of these problems led us to identify other elements. We then proceed to discuss the importance and implications of the potential and difficulties associated with gamification and serious games in the context of our results.
Increasing Sexual Dysfunction in Society and Management with Psychotherapy, Rasayanam or Vajikaran
Authors: Yadav Dr. Dinesh Kumar , Upadhyay Dr. Subhash , Sakshi Dr. , Kumari Dr. Neelam
Published: November 2024

Abstract: The world's oldest medical system is called Ayurveda. The two main goals of Ayurveda are to treat ailments and to enhance life and health. To increase memory, immunity to illness, complexion, lustrous perfection, supreme strength, sense organ, intelligence, and physical strength and brilliance, is known as Rasayana. To enhance potency health and reproductive health known as vajikarana in ayurveda. Acharya Charaka mentions that rasayana and vajikaran have qualities that are used to prevent diseases or restore health, and also have advantages for sexual health. Vajikarana means to enhance ejaculation, semen quality, or both virilities. The increasing occurrence of sexual dysfunction in modern society has emerged as a significant public health concern, impacting individuals' quality of life and interpersonal relationships. Factors contributing to this rise include stress, anxiety, lifestyle changes, and societal pressures that influence sexual health. This article explores the multifaceted causes of sexual dysfunction, examining its psychological, physiological, and sociocultural dimensions. This article emphasizes the crucial role of psychological counseling as a management strategy, improving communication between partners, and fostering a supportive environment for sexual health. This article approaches the combination of psychological interventions with medical treatments to enhance overall well-being and sexual satisfaction. By raising awareness and promoting friendly counseling services.
Real Time Collaborative Whiteboard
Authors: Singh Prabhnoor
Published: November 2024

This experiment developed a whiteboard web application that will be versatile, hence usable both as a tool in teaching and one in entertainment. There is a pencil of all sizes and colors allows people highly to customize the drawing capability. It has several shapes-circles, rectangles, lines-for structured illustrative works. The platform can also be allowed for free-hand drawing and sketching for artistic expression or note-taking. An important feature of the application is the non-stuttering user interface during transit from one tool to another. Hence, it is perfect for live lesson educators or busy people working on creative tasks. A desirable feature of the application is that it has a "Save as Photo" function where the work can be captured in the image format and shared with colleagues or preserved for eventual review. This connects the user from the old means of whiteboards to the new avenues of digital interfaces, thereby enriching interaction in learning environments online and serving as a fun way of creativity and entertainment. The user base of the whiteboard application is encompassed by students and teachers, hobbyists, and artists, due to its wide-ranging intuitive control, size and color customization, and shape-drawing tools. This makes it a widely-used, enabling tool for digital content creation and collaborative work.
Development and Implementation of a “Real Estate Web Application” for Modern Web Application
Authors: Kumar Amit
Published: November 2024

A real estate management system is one of the modern software solutions developed to keep up and improve on the management and operating process within the real estate industry. Real estate is one of the fastest-growing industries on a global level and thousands of properties are issued every day, which calls for effective automation in some property management activities. REMS has solutions to all these issues in the very complete system platform that encompasses various aspects of property management, such as placement, tenant management, tracking of finances, and scheduling of maintenance. All these are brought together by the most advanced technologies, namely cloud computing, artificial intelligence, and data analytics, when forming a strong and user-friendly system for the real estate professional. Generally, it provides a database core that allows instant access to information regarding properties which can make communication and collaboration between parties in the management of property ownership-owners, managers, tenants, and service providers-well easier. Its easy-to-use interface gives the user the ability to deal most efficiently with property listings, tenant information, rental payments, financial reports generation, and requests for maintenance. The main elements of the system include an intelligent listing module that enables real estate agents to give detailed descriptions, images, and pricing information about their property listings. Management of tenants through a specific module ensures effective onboarding while still regulating managerial management of rental agreements, rent collection, and other communications with tenants. REMS also incorporates a full-scale financial tracking component. In the case of rent calculation, it would further advance into generating invoices and track expenses and offer detailed financial reports.
From Pixels to Predictions: A Comprehensive Survey of Image Classification
Authors: Boran Lokesh Kumar
Published: November 2024

Image classification, a fundamental task in computer vision, has undergone significant evolution over the years, driven by advancements in deep learning and machine learning techniques. This paper presents a comprehensive survey of image classification techniques, covering its journey from early methods to state-of-the-art approaches and future directions. We delve into the fundamentals of image classification, including traditional methods and the pivotal role of Convolutional Neural Networks (CNNs). The survey explores advanced techniques such as transfer learning, attention mechanisms, and multimodal learning, along with their applications across various domains including healthcare, autonomous vehicles, social media, and more. Additionally, future trends and directions in image classification are discussed, focusing on weakly supervised learning, multimodal learning, continual learning, and ethical considerations. Through this survey, we aim to provide insights into the past, present, and future of image classification, highlighting its significance, challenges, and promising avenues of research and application.
Impacto del uso del polígono virtual en la formación del futuro oficial de la Policía Nacional de Colombia
Authors: Puche Cabrera Onisa Janeth , Valencia Rodríguez José Luis , Cervantes Estrada Luis Carlos
Published: November 2024

El estudio tiene como objetivo establecer el impacto del polígono virtual en el proceso de formación inicial del oficial de policía, en la Escuela de Cadetes de Policía “General Francisco de Paula Santander” (ECSAN). Se utilizó un diseño metodológico mixto mediante el uso de diferentes instrumentos, con un alcance descriptivo-explicativo de las categorías identificadas. Se aplicaron dos técnicas de recolección de información: la encuesta y el focus group. La población, objeto de estudio, estuvo compuesta por estudiantes de la ECSAN de diferentes semestres del programa de pregrado en Administración Policial, egresados con hasta tres años de antigüedad, docentes de la asignatura de tiro y expertos académicos e investigadores de la Policía Nacional. Los principales resultados mostraron que el uso del simulador virtual de tiro contribuye significativamente al proceso de formación y adaptación inicial de los estudiantes con las armas de fuego. Asimismo, es un escenario que permite cometer errores sin afectar a las personas, materiales e insumos. Sin embargo, es preciso la modernización permanente de los escenarios virtuales utilizados y el empleo de los instructores en estas herramientas virtuales. En conclusión, el polígono virtual es una herramienta de aprendizaje fundamental, que en todo caso debe estar acompañada de retroalimentación permanente de los instructores, así como de los currículos flexibles, dinámicos y transdisciplinares.