bluuebunny/crossref_metadata_2025 huggingface dataset:
Empreendedorismo e coronavírus: impactos, estratégias e oportunidades frente à crise global
Authors: Leite Gustmann de Castro Beatriz , Eccel Pontelli Greice , De Fátima Paz Nunes Andrieli , Marques Kneipp Jordana , Medianeira Flores Costa Vânia
Published: April 2021

Objetivou-se identificar os impactos e estratégias de empreendedores de diferentes segmentos de mercado no cenário de crise da COVID-19. Foram realizadas entrevistas semiestruturadas, com 17 empreendedores de diversos segmentos, as quais foram transcritas e submetidas à análise de conteúdo. Os resultados apontaram impactos de ordem pessoal e profissional, com ênfase no campo financeiro; bem como nas estratégias de divulgação de produtos e serviços, foco na qualidade e flexibilidade nas condições de pagamento. Em relação às oportunidades, constatou-se menção quanto ao crescimento profissional, reinvenção, novas formas de trabalho, aperfeiçoamento profissional e e-commerce. Conclui-se que, alguns segmentos apresentam aumento de demanda, evidenciando a tendência de mudança no padrão de consumo da sociedade em função do cenário atual. Por fim, sugere-se a ampliação deste estudo quanto aos participantes da pesquisa, extensão geográfica e segmentação de mercado.
Family business resilience under the COVID-19: A comparative study in the furniture industry in the United States of America and Colombia
Authors: González Ana Cristina , Pérez-Uribe Miguel Ángel
Published: April 2021

COVID-19 has impacted the world and has forced organizations to adapt to the “new normal”, and family businesses have not been exempt. In this study, we answer two research questions; how prepared are family businesses to face shocks like the pandemic? and, do contexts matter in that response? Using the Resource-Based View of the firm, in this qualitative exploratory study we analyze the resources and capabilities deployed by two business families owning three family businesses in the office furniture industry in the countries of Colombia and the USA. Our findings indicate that indeed family businesses are resilient, but the resources and capabilities deployed and their uses are different according to the context, suggesting a contingent familiness during a crisis.
Single-hole, ruptured parenchymal arteriovenous fistula of the mesencephalon : Not known vascular malformation of the brain or a posthemorrhagic entity?
Authors: Kulcsár Zsolt , Machi Paolo , Vargas Maria Isabel , Schaller Karl , Lovblad Karl Olof
Published: April 2021

The subtypes of brain arteriovenous malformations, with direct, single-hole fistulas without co-existing nidus are not described as existing entities inside the brain parenchyma but on the pial surface. True parenchymal arteriovenous malformations present with nidal structure, even if they are small, whereas surface lesions may present a direct fistulous configuration. In this case of midbrain haemorrhage a direct arteriovenous fistula was detected at the level of the red nucleus between a paramedian midbrain perforator artery and a paramedian parenchymal vein, with pseudo-aneurysm formation at the fistulous connection, without signs of adjacent nidus structure. The hypothesis whether a pre-existing arteriovenous fistula ruptured or a spontaneous haemorrhage has caused the fistulous connection is discussed.
Cause of recurrent rhabdomyolysis, carnitine palmitoyltransferase II deficiency and novel pathogenic mutation
Authors: Çakar Nafiye Emel , Gör Zeynep , Yeşil Gözde
Published: April 2021

Carnitine palmitoyltransferase II (CPT II) deficiency is an autosomal inherited metabolic disorder in which the β-oxidation of the long chain fatty acids is defective. The clinical presentation may be in various forms; it presents itself in the severe form during neonatal and infantile periods and as the less severe myopathic form in the school age and adolescence. While the severity of the rhabdomyolysis attacks varies, occasionally the clinical course may be complicated with acute renal failure. Acylcarnitine analysis may help in the diagnosis of CPT II, but its normality does not indicate the absence of the disease. If there is strong suspicion, genetic analysis should be performed on the cases. In this article, we present a 15-year-old male patient who had two rhabdomyolysis attacks triggered by infection and starvation. Acylcarnitine analysis of the case was normal, CPT II deficiency was considered when the history was evaluated, and CPT II gene c.137A>G (p.Gln46Arg) homozygous novel pathogenic mutation was detected. CPT II deficiency is one of the most common causes of metabolic rhabdomyolysis in patients with recurrent episodes of rhabdomyolysis.
Marginalisasi Ojek Pangkalan dalam Iklan Grab Versi #PilihAman
Authors: Suryani Fani Zafira , Hermawan Navika Dwi Nurfariza
Published: April 2021

Penelitian ini dibuat untuk menyadarkan masyarakat bahwa masih adanya praktik marjinalisasi dalam iklan ini yang tidak kita sadari. Dengan adanya iklan tersebut merugikan pihak ojek pangkalan karena anggapan atau persepsi yang terbentuk dari adanya iklan ini sehingga orang dapat berpaling dan menggunakan ojek online. Dalam iklan ini ojek pangkalan digambarkan tidak memiliki keselamatan yang baik dalam bergendara dan juga perawatan motor. Penelitian ini menggunakan metode semiotika oleh Roland Barthes yang mengembangkan dari pemikiran Ferdinand De Saussure untuk menganalisis objek penelitian dalam iklan Grab. Tujuan dari penelitian ini untuk mengetahui marginalisasi ojek pangkalan yang terdapat pada iklan Grab versi pilih aman. Berdasarkan temuan dan diskusi dalam penelitian ini, iklan Grab #PilihAman telah memarginalisasi ojek pangkalan melalui beberapa hal yaitu sistem keamanan, informasi pengendara, dan motor yang terawat.
Strategi Komunikasi Pemasaran Produk Kopi Kawa Daun Tanah Datar dalam Membangun Brand Awareness
Authors: Endri Engga Probi , Prasetyo Kurniawan
Published: April 2021

Kawa daun telah dikenal masyarakat Minangkabau yang syarat akan nilai budaya dan nilai historisnya. Hadirnya industri kreatif, Kopi Kawa Daun sebagai produk Tanah Datar, Sumatera Barat. Selain mencari market yang luas, branding produk menjadi penting untuk pencapaian jangka panjang brand. Desain, pesan, promosi serta komunikasi brand Kopi Kawa Daun, dirancang sedemikian rupa sehingga mencirikan nilai historis dan identik dengan budaya Minangkabau. Komunikasi pemasaran itu sendiri merupakan proses penyampaian pesan dengan cara bujukan atau ajakan untuk menawarkan sebuah produk baik barang atau jasa. Dalam menjalankan strategi pemasaran guna mendapatkan perhatian dan juga kepercayaan konsumen terhadap suatu merek, perusahaan memerlukan media atau saluran yang dapat dijadikan sebagai perantara dalam proses komunikasi antara perusahaan dengan konsumen. Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis strategi komunikasi pemasaran produk kopi kawa daun Tanah Datar dalam menciptakan brand awareness. Penelitian ini menggunakan metode penelitian yang digunakan adalah kualitatif, dalam pengumpulan data menggunakan wawancara mendalam, observasi dan dokumentasi. Informan dipilih dengan menggunakan teknik purposive sampling. Sementara untuk melihat keabsahan data penelitian ini menggunakan triangulasi sumber.Berdasarkan hasil penelitian diketahui bahwa Komunikasi Pemasaran Kopi Kawa Daun untuk membangun brand awareness konsumen terhadap produk. Brand awareness publik dikategorikan berdasarkan pengalaman publik yaitu pada tahap brand recall dan brand recognition dan berdasarkan brand produk yaitu pada tahap top of mind.
Decision Support System for Stock Portfolio Selection Using Artificial Intelligence and Machine Learning
Authors: Patalay Sandeep , Bandlamudi Madhusudhan Rao
Published: April 2021

Investing in stock market requires in-depth knowledge of finance and stock market dynamics. Stock Portfolio Selection and management involve complex financial analysis and decision making policies. An Individual investor seeking to invest in stock portfolio is need of a support system which can guide him to create a portfolio of stocks based on sound financial analysis. In this paper the authors designed a Financial Decision Support System (DSS) for creating and managing a portfolio of stock which is based on Artificial Intelligence (AI) and Machine learning (ML) and combining the traditional approach of mathematical models. We believe this a unique approach to perform stock portfolio, the results of this study are quite encouraging as the stock portfolios created by the DSS are based on strong financial health indices which in turn are giving Return on Investment (ROI) in the range of more than 11% in the short term and more than 61% in the long term, therefore beating the market index by a factor of 15%. This system has the potential to help millions of Individual Investors who can make their financial decisions on stocks and may eventually contribute to a more efficient financial system.
An Efficient and Scalable Heart Disease Diagnosis System with Attribute Impact Based Weights and Genetic Correlation Analysis
Authors: Meda Srikanth , Bhogapathi Raveendra Babu
Published: April 2021

Fuzzy neural network (FNN) is playing a vital role in processing of complex data mining applications like medical diagnosis, speech recognition, text processing, image processing etc. Fuzzy neural networks simulate the human brain functionality with fuzzy logic decision making capabilities, to achieve more accuracy in feature selection process of complex data mining applications. Today cardiovascular diseases become a serious global health issue and approximately more than 31% of all global deaths are happening due to cardiovascular diseases reported by WHO. In order to prevent and control the cardiovascular diseases, an efficient and accurate heart disease diagnosis system (HDDS) has to be designed with the state of the art feature based data classifiers. In recent, some research articles introduced HDDS using popular data mining techniques like FNN, but they are suffering from accuracy in allocation of attribute weights and attribute correlation analysis, pattern recognition, forecasting. To address the problems in designing the HDDS, in this paper, Fuzzy Neural Networks has been used with empowered input layer and hidden layers to achieve the high accuracy and performance, while processing the huge set of medical data records. We designed an Attribute Impact calculation procedure to assign the accurate weight values to the attributes and we proposed a Genetic Correlation Analysis algorithm to do correlation analysis which helps in improving the performance.
PATTERNS OF RENAISSANCE EPISTOLOGRAPHY IN THE EXPERIMENTAL PROSE OF ALEXANDER ILYANEN
Authors: Markov Alexander V.
Published: April 2021

The online prose of Alexander Ilyanen, recognized as one of the most significant experiments of Russian literature today, is not only a reflection on the possibilities of writing and utterance, but also an experience of rewriting of written forms. Recent prose of Ilyanen is a kind of philological observation of the usability of different types of writing to assemble a meaningful statement about the current quarantine situation. Correlation of these types of writing with the usual genres is not relevant, even introducing general framework of the novel and drama. Renaissance Italian epistolography as a way of producing situations, rather than roman à clef, clarifies Ilyanen’s prose strategies. A detailed analysis of the Renaissance letters by Poggio proves that he did not affirm the new model of language use, reviving the Cicero ideal, but he controlled effects of writing and biography, to improve official policy. The irony, intrigues, hints, social designing in these letters anticipate the tactics of professional blogging by eminent writers, but differ in responsibility for political decisions of both authors and persons mentioned.
Análise temporal por sensoriamento remoto da supressão de vegetação nativa em vales na cidade de Maceió, Brasil
Authors: Cerqueira Michelle Adelino , Santos Polyanna Omena Costa , Farias Vera Nubia Carvalho de , Chagas Júnior Vivaldo Ferreira , Barbosa Ricardo Victor Rodrigues
Published: April 2021

O artigo objetivou analisar a supressão da vegetação nativa em área de vale tomado por ocupações irregulares na cidade de Maceió a partir do uso de sensoriamento remoto com algoritmo de Índice de Vegetação por Diferença Normalizada (NDVI). A investigação tomou como estudo de caso a Grota do Aterro, com vistas a verificar os impactos provenientes da ocupação antrópica sobre a vegetação nativa. A análise temporal foi realizada com imagens de 1999 e 2020. Os resultados mostraram que a redução da vegetação nativa foi da ordem de 3 ha, equivalente a 50% da massa vegetal existente em 1999. A investigação apontou, entre outros aspectos, a viabilidade de mapear e identificar alterações na vegetação nativa a partir do mapa de NDVI, com a perspectiva de subsidiar políticas públicas para manutenção e conservação da vegetação nativa, especialmente em áreas ambientalmente frágeis.
Paleotemperature modeling of hydrocarbon generation centers and their role in the formation of «Paleozoic» oil deposits (Ostaninskoe field, Tomsk region)
Authors: Isaev Valery I. , Galieva Margarita F. , Aleeva Anna O. , Lobova Galina A. , Starostenko Vitaly I. , Fomin Alexander N.
Published: April 2021

Study and exploration of the pre-Jurassic oil and gas complex in Western Siberia is one of the aspects of hydrocarbon raw-material base development. The main scope of this study is to locate the source of Paleozoic hydrocarbons. The problem of modeling and assessing the role of Paleozoic-Mesozoic hydrocarbon generation centers in the formation of «Paleozoic» oil deposits in the section of the Ostaninskoe oil and gas condensate field (Tomsk region) is solved. In the formation of the oil and gas content of the pre-Jurassic basement two reservoirs are involved: the weathering crust and the roof of the bed-rock Paleozoic. The first was formed during the period of 213–208 Ma, and the second is genetically determined by epigenetic processes in the weathering crust. Potential hydrocarbon sources for the weathering crust and bed-rock Paleozoic reservoirs are Domanic type rocks in the crystalline basement: Larinskaya S1lr, Mirnaya D1mr, Chuzikskaya D2cz, Chaginskaya D3cg Formations, as well as Tyumenskaya J1-2tm and Bazhenovskaya J3bg Formations in sedimentary cover.
To perform joint paleotemperature modeling of sedimentary basins of the «modern» Jurassic-Cretaceous and Paleozoic «paleobasins», the Ostaninskaya 438P well was selected, which is due to the presence of measured temperatures both in the Jurassic sections and in the pre-Jurassic formations, as well as fluid inflows from the pre-Jurassic horizons into the well. At the first step, the solution of the inverse problem of geothermics was obtained using reservoir temperatures and vitrinite reflectance measurements from the Mesozoic deposits: density of deep heat flow from the base of sedimentary section was determined, which is characterized by a quasi-constant value from the Jurassic to the present. The second step was to solve the inverse problem using vitrinite reflectance measurements from Paleozoic sediments. As a result, the heat flow value was obtained for the key moments of geodynamic history of the stratigraphic section, starting from the Silurian. By solving direct problems of geothermics with the given values of heat flow, the structural-tectonic and thermal history of four Paleozoic potential oil source formations (as well as Jurassic – Bazhenov and Tyumen Formations) has been retraced. The controversial aspects of the heat transfer model in the section of the Ostaninskoe field are considered.
It has been established that the Tyumen and Bazhenov oil sources (most likely Bazhenov) are syngenetic (in terms of generation, accumulation and preservation time) for the weathering crust and the Paleozoic reservoirs. The role of the Chaginskaya Formation as gas source is insignificant.
Prediction of hydrogeochemical effects in clayey cap rocks during underground storage of hydrogen with methane
Authors: Abukova Leyla A. , Abramova Olga P.
Published: April 2021

Theoretical issues of joint underground storage of hydrogen with methane are poorly studied, and practical examples are rare. Therefore, it is extremely important to analyze the mutual influence of hydrogen-methane mixtures and the host geological environment. This article presents material that makes it possible to substantiate the most significant hydrochemical processes that affect the transformation of cap rocks. For this purpose, the results of our own experiments, as well as published data on the study of the influence of hydrochemical conditions on the diffusion loss of hydrogen, its interaction with rock-forming minerals, organic matter, and pore waters were used. A quantitative assessment of the decrease in the moisture saturation of clay-rocks samples and, as a consequence, the loss of the mass content of mineral and organic substances is given. It was found that the cyclic change of thermobaric effects leads to a change in the redox conditions in the system “rock ↔ pore water” and is accompanied by an increase in the reactivity of calcium, magnesium, sulfur, iron. The saturation indices of pore water with carbonate and sulfate calcium salts were calculated under the conditions of their precipitation, dissolution, and removal from solution. The interpretation of the experimental data made it possible to substantiate the most probable transformations in clayey cap rocks, which affect their screening capabilities. It is recommended to take into account, when designing and operating storage facilities for hydrogen-methane mixtures, the variety of accompanying hydrochemical and microbiological processes that affect the change in the filtration properties of cap rocks.
Zjawiska chemiczno-technologiczne podczas zabiegu cementowania otworu w aspekcie projektowania rur okładzinowych ze szczególnym uwzględnieniem ich wytrzymałości na zgniatanie i rozrywanie
Authors:   Firma Konsultingowa „WES”, Witek Wiesław , Rzepka Marcin ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy
Published: April 2021

One of the most important issues that needs to be addressed in the borehole design process is the optimal design of the borehole structure, including the appropriate selection of individual casing columns and their setting given the assumed geological and cementing-technical conditions. Specific geological and technical conditions imply a number of both conditions and constraints. A kind of dimensional unification of pipes adopted by API many decades ago, i.e. a series according to the outer diameter of the pipes, constitutes the main natural constraint. Other elements of this unification, such as a series of steel grades or of classic and PREMIUM thread connections were implemented gradually as drilling technology developed. Regardless of these conditions, one thing always remains the same when designing casing and selecting production tubing, i.e. maintaining the balance between the existing loads acting on the pipes during the drilling process and operation of the borehole and the minimum mechanical strength of the pipes. This article reviews the methods and guidelines for casing pipe designing published by API and of computer programs, including StressCheck, which is currently one of the commonly used pipe design tools. The strength issues discussed in the article refer mainly to the pipe body, ignoring the complex issue of the strength of the thread connections, especially those of PREMIUM type, whose qualification is not subject to API standards, but to the guidelines contained in ISO 13679.
Female Indian ring-necked parakeet in cage
Authors: Lee Wendy
Published: April 2021

Photograph of a female Indian ring-necked parakeet in a cage, playing with a yellow toy taken by Wendy Lee. (Source: Emma Lewis)
MOTIVAÇÕES E CONSEQUÊNCIAS DA TRANSPARÊNCIA NA POLÍTICA: A CONSTRUÇÃO SOCIAL DE UM PROBLEMA PÚBLICO

MOTIVATIONS AND CONSEQUENCES OF TRANSPARENCY IN POLITICS: THE SOCIAL CONSTRUCTION OF A PUBLIC PROBLEM
Authors: Bento Juliane Sant’Ana
Published: April 2021

Resenha sobre o manuscrito: L’argent de la politique. Paris: Les Presses de Science Po, do autor Érick Phélippeau.
Determinanty i źródła finansowania ekoinnowacji w polskich przedsiębiorstwach
Authors: Burzyńska Dorota , Hajdys Dagmara
Published: April 2021

Zagadnienie ekoinnowacyjności przedsiębiorstw jest ważnym obszarem badań współczesnej gospodarki. Wdrażanie innowacji ekologicznych w przedsiębiorstwach może przynieść wiele korzyści, związanych przede wszystkim z obniżeniem kosztów działalności przedsiębiorstwa i zwiększeniem jego konkurencyjności, a co za tym idzie – ze wzrostem konkurencyjności polskiej gospodarki na tle gospodarek europejskich oraz światowych.
Celem artykułu jest przedstawienie wybranych zagadnień związanych z ekoinnowacyjnością polskich przedsiębiorstw, w szczególności ich specyfiki, efektywności, czynników warunkujących rozwój oraz źródeł finansowania.
Z dotychczasowych badań wynika, że większość przedsiębiorstw podejmujących działania innowacyjne w obszarze ekologii skupia się na innowacyjnych rozwiązaniach technologicznych, a w mniejszym stopniu na zmianach w zatrudnieniu czy strukturze organizacyjnej jednostki. Nie mniej ważnym elementem w przedmiotowym działaniu jest zarządzanie wiedzą.
Dotychczasowe inwestycje w ekoinnowacje są niewystarczające. Jest to rezultat braku odpowiednich zasobów finansowych i technicznych, a także wiedzy i wykwalifikowanej kadry. Niezbędne wydają się zatem działania wspierające rządu oraz otoczenia instytucjonalnego biznesu.
On Several Polish Poems From 1829–1870 with Venice in the Background
Authors: Berkan-Jabłońska Maria
Published: April 2021

The subject of the article is a review of images of Venice recorded in Polish poetry between the years 1829–1870. The paper deliberately stops in the 1870s in the selection of the literary material to be analysed, focusing on the Romantic and post-Romantic tradition. Due to the different artistic value of the works, the author adopted the formula of a historical and literary “catalogue” ordered chronologically and partly problematicised according to the functions which Venetian scenery or culture perform in them. Attention is drawn to the fact that Venetian motifs present in the poetry of Polish artists tend to be related to particular phenomena and topics, such as Byronism, Gothicism, political and national camouflage, love and existential masks, conflict between people and power. The authors referred to in the paper include, among others, Adam Mickiewicz, Józef Ignacy Kraszewski, Zygmunt Krasiński, Edward Dembowski, Edmund Chojecki, Karol Baliński, Mieczysław Gwalbert Pawlikowski, Teofil Lenartowicz, Feliks Wicherski, Teofil Nowosielski, Aleksander Michaux and Wiktor Gomulicki.
All the Faces of Grochowiak
Authors: Juchniewicz Andrzej
Published: April 2021

The hereby reviewed book by Jacek Łukasiewicz entitled Poeta Grochowiak has been an impressive and monumental undertaking, yet it fulfils only some of the pro­mises made by its author. According to the reviewer, the fact of its release offers grounds for a discussion of the status of theory and the validity of abandoning it in favour of a reading devoid of methodological regime which elevates the importance of pleasure. The main problem which emerges after reading Łukasiewicz’s opus magnum is the issue of selecting the recipient of the monograph (a regular person or a specialist), which in turn conditions the mode of study of the poet’s output. Łukasiewicz’s monograph amplifies the conviction that Grochowiak’s poetic works should be read using new methodologies, which could indicate the poet’s innova­tion in terms of increasing the value of objects and animals as the most important components of his universe. According to the reviewer, what requires justification the most is the need to comment on nearly all poems from the poet’s released collec­tions, which is supposed to be facilitated by the researcher’s identification of seve­ral categories around which his narration centred. The book was divided into two parts. The first part is predominantly chronological, while the second part follows a contextual organisation, which considering the book’s size causes problems in the form of repeated discussions of several poems. The reviewer noted the fact that some were subjected to careful reading several times while other, especially those not released, did not receive a sufficient amount of attention. Additionally, Łukasie­wicz did not attempt to define the gravity of the topic of the most recent world war in Grochowiak’s output or to reconstruct the poet’s polemic with Julian Przyboś during the mature stage of the former’s creative life. An in-depth analysis is also demanded for poems discussing the suffering of animals and inter-species commu­nity, which Łukasiewicz deemed noteworthy yet his comments to those do not help readers find indications of eco-critical awareness in Grochowiak’s works. The new monograph devoted to the output of the author of Kanon sheds new light on many problems and biographical contexts as the critic knew the poet, yet some issues re­quire further study. Poeta Grochowiak as the crowning of Łukasiewicz’s efforts into the study of the poet’s output is impressive, yet there is no doubt that a panoramic view does not guarantee noticing every detail, and it is in details that Grochowiak’s poetic sensitivity is lodged.
Odnośnie artykułu Katarzyny Kuczyńskiej-Koschany "«Panienka, Godzina Polski», 1916: Irena Tuwim’s Literary Debut”
Authors: Stawiszynska Aneta
Published: April 2021

Poszukiwanie debiutu Ireny Tuwim nie należy do rzeczy łatwych. Jej pierwsze utwory, pisane w wieku młodzieńczym publikowane były na łamach prasy łódzkiej, często pod pseudonimami, nadanymi przez jej brata, Juliana, który w tajemnicy przed siostrą zanosił jej wiersze do zaprzyjaźnionych redakcji. W świetle dzisiejszej wiedzy za najwcześniej opublikowane wiersze poetki należy uznać utwory „Przy kominku” oraz „Szczęście” zamieszczone w pierwszej połowie 1914 r. na łamach jednodniówki literackiej „Życie Łódzkie” pod red. A. Nullusa, współtworzonej przez J. Tuwima. Wspomniane wiersze zostały podpisane pseudonimem „Ira Blanka”. Ponadto wierze zostały opatrzone przypisem, z którego wynikało, że ich autorka miała 15 lat a wiersze zostały opublikowane bez jej wiedzy.
Expression of the immune checkpoint B7-H3 in tumor and its soluble form in serum of patients with bone neoplasms
Authors: Kushlinskii N. E. , Kovaleva O. V. , Alferov A. A. , Kuzmin Yu. B. , Sushentsov E. A. , Stilidi I. S.
Published: April 2021

B7-H3, also called CD276, is a type I transmembrane glycoprotein that is encoded on human chromosome 15. It was discovered back in 2001. The original study described it as a positive co-stimulant, as it can stimulate T-cell response and IFN-y production. However, recent researches have shown that B7-H3 is involved in T-cell inhibition. A B7-H3 receptor has not been yet identified, and this may explain the complex immunomodulatory activity of B7-H3, as it can have more than one binding partner with different functions. Expression of the B7-H3 protein has been found on activated immune cells such as T-cells, NK cells and antigen presenting cells. Interestingly, it is overexpressed in a wide range of tumor cells and is associated with disease progression and outcome. The soluble form of this protein is also of particular interest. Increased sB7-H3 levels in the plasma of bone tumor patients might be their important diagnostic criterion.
Alcohol's Effects on Bystander Intervention Strategies to Prevent Sexual Assault
Authors: Bridges Ana J. , Mobley Alita M. , Augur Isabel F. , Marcantonio Tiffany L. , Wiersma-Mosley Jacquelyn D. , Jozkowski Kristen N. , Ham Lindsay S.
Published: April 2021

Alcohol's effects on bystander responses to potential sexual assault situations are understudied. In this mixed-methods study, we examined quality of bystander responses in intoxicated versus sober people. Participants were 121 young adults (ages 21–29, 50% female) randomly assigned to consume alcoholic beverages or soda water. After drinking, participants listened to a sexual assault vignette and completed a semistructured interview assessing how they would respond if they had witnessed the situation. Nearly all participants reported they would directly intervene if faced with the situation. Intoxicated participants and men were significantly less likely to use high-quality bystander intervention strategies than were sober participants and women. Results suggest that alcohol intoxication may negatively impact the likelihood that bystander intervention efforts will be helpful.
Socially active groups of Russian society: forming a demand for democratic participation
Authors: Petukhov Vladimir V. , Petukhov Romav V.
Published: April 2021

Based on the data of public opinion polls, the article assesses the degree of politicization and involvement in the practice of civic participation of a social group of “professionals”, by which we mean the Russian people with higher education and, as a rule, earning a living through mental labour. It is believed that this very part of society is one of the main pillars of democratic regimes in most of the developed countries. In the Russian realities, as the authors of the article note, the representatives of this group for a long time were focused on individual self-realization and avoided participation in the social and political life of the country, that led to the lack of adequate representation of their interests in public policy. In the past few years, as demonstrated by the FCTAS RAS studies, a demand for democratic participation began to form against the backdrop of the awareness of “professionals”, as well as of many other representatives of the middle class, of the importance of a favorable social environment (security, including environmental security, the presence of a developed social infrastructure, non-interference in the citizens private life, etc.). The authors believe that this is a request not only for adequate representation of the interests of these groups in the state, but also for changing the very nature of relations between the society and the state. The authors emphasize that the direct involvement of “professionals” in the practice of political and social participation is of “pulsating” nature yet, representing their reaction to certain political events that seem important. Despite the fact that the level of this involvement is not very high, nevertheless, it noticeably (and sometimes multiple) exceeds similar indicators of other socio-professional groups. In the event of a further deterioration in the quality of the socio-political environment and a decrease in the standard of living in the country, the “background” interest of the majority of Russian “professionals” in politics might be transformed into systematic and more active practices of political participation.
Clinical analysis of the effectiveness of the linear stapling apparatus for open and endovideosurgical surgeries
Authors: Supilnikov A. A. , Simatov S. A. , Vartanov V. Y.
Published: April 2021

On the basis of clinical experience of making anastomoses by apparatus and manual methods the comparative analysis of complications in the form of anastomosis failure during operations on the colon in cancer patients performed by both open and video endoscopic methods was carried out.
Cirurgia Obstétrica com Risco Hemorrágico Major em Testemunha de Jeová
Authors: Carp Maria , Maurício Sandra , Lança Filipa
Published: April 2021

A hemorragia obstétrica continua a ser a principal causa de morbimortalidade materna, sendo que a abordagem de grávidas que recusam alotransfusão, como é o caso das Testemunhas de Jeová, coloca importantes questões médicas, éticas e legais. Reporta-se um caso de uma doente Testemunha de Jeová, submetida a cesariana com fatores de risco para hemorragia major, incluindo existência de um mioma gigante, em que se evitou a transfusão e foi utilizado ácido tranexâmico profilático. A abordagem de Testemunhas de Jeová em contexto de cirurgia obstétrica com risco hemorrágico major implica a definição de estratégias anestésico-cirúrgicas para a minimização de perdas hemorrágicas, a otimização da entrega e consumo de oxigénio, o aumento da síntese de hemoglobina, a correção de defeitos de coagulação e melhoria da hemostase. Revemos a importância do planeamento multidisciplinar, o recurso ao tromboelastrograma e a administração precoce de fibrinogénio e ácido tranexâmico, de acordo com o consentimento informado das doentes.
‘TB OR NOT TB?’: The Importance of Appropriate Screening
Authors: Lemos Ana Pereira , Garcia Ana Margarida , Candeias Flora , Brito Maria João
Published: April 2021

N/a.
Saúde Comunitária para Todos
Authors: Carvalheiro Mafalda , Sá Guerreiro Cátia
Published: April 2021

N/a.
COVID-19 and Moral Distress in Healthcare Professionals: Can Ethics Committees Make a Difference?
Authors: Martinho Sérgio M. , Carvalheiro Ana Mafalda , Silvestre Margarida
Published: April 2021

N/a.
A study of ofloxacin and levofloxacin photostability in aqueous solutions
Authors: Frąckowiak Anita , Kamiński Bartosz , Urbaniak Bartosz , Dereziński Paweł , Klupczyńska Agnieszka , Darul-Duszkiewicz Monika , Kokot Zenon J.
Published: April 2021

Introduction. The photostability is one of the most important properties of drugs. A comprehensive study of ofloxacin (OFX) and levofloxacin (LVX) photostability in aqueous solutions was performed. Ofloxacin is a chemotherapeutic agent belonging to the second generation fluoroquinolones and is a racemate of (R)-(+)-ofloxacin and (S)-(-)-ofloxacin (LVX).Material and Methods. Samples of OFX and LVX were subjected to stress conditions of UV irradiation using a mercury-vapor lamp. The study involved development of enantioselective high-performance liquid chromatography (HPLC) and high-performance capillary electrophoresis (HPCE) methods for separation of OFX enantiomers and their degradation products. These methods were used to monitor the degradation process of OFX and LVX under irradiation and to determine the kinetics of degradation of these antibacterial agents. Moreover, the identification of photoproducts was also attempted. The structure of the main photoproducts was examined by mass spectrometry (MS).Results and Conclusions. Using HPLC method it was possible to observe two products of OFX degradation and only one for LVX, while using HPCE method eight products of OFX degradation and six of LVX were observed. Some of the photoproducts retain character of optically active compounds. The trend of the photodegradation of both tested compounds was described by autocatalytic reaction proceeding according to the Prout-Tompkins model. Some of the products of the decomposition catalyze this reaction. The rate of degradation was similar for both enantiomers but t0.5 was slightly longer for LVX than OFX. Based on MS experiments the photodegradation products of the studied fluoroquinolones and possible pathways of UV induced decay were identified.
Project “Equalizing opportunities – raising competence of children with disabilities”
Authors: Piasecki Bartosz , Mojs Ewa , Sudoł Anna , Samborski Włodzimierz
Published: April 2021

The project will enable the use of the Tomatis therapy for children with central auditory processing disorders and the introduction of a proprietary curriculum preparing children to learn English in primary school – based on the method that streamlines the auditory analysis, on the proprietary language integration CDs used in the Tomatis method and on individual educational and therapeutic lessons with the teacher. The curriculum will be developed in the course of research under the guidance of prof. UM dr hab. Ewa Mojs from the Poznan University of Medical Sciences. The leader of the consortium implementing the project is the Foundation for Local Activity. The innovation has a high potential for implementation. Applicants to begin with estimate ultimately the ability to implement the program in the first year in 350 schools with the right equipment.
Aborted myocardial infarction in patients undergoing primary percutaneous coronary intervention
Authors: Pyda Małgorzata , Grajek Stefan , Oleśkowska-Florek Weronika , Lesiak Maciej , Siniawski Andrzej , Gwizdała Adrian , Grygier Marek , Araszkiewicz Aleksander
Published: April 2021

Introduction. The outcome of patients with ST-elevation myocardial infarction (STEMI) strongly depends on a successful reperfusion. In some patients receiving an effective treatment myocardial infarction can be aborted.Aim. The aim of the study was to estimate the incidence, clinical outcome, prognosis and inflammatory response in patients with aborted MI.Material and methods. 119 consecutive patients with STEMI treated with a primary percutaneous coronary intervention (pPCI) were enrolled in the study. Aborted MI was diagnosed when the maximal increase in cardiac enzymes (CK-MB) was up to twice the upper limit of normal (CK-MB ? 50 U/I) and at least 50% reduction of ST-segment deviation was observed within 90 min of pPCI.Results. Aborted MI was diagnosed in 16 subjects (13.4%). Patients with the aborted MI had lower serum troponin I levels (p < 0.0001). The time to treatment was significantly shorter in the aborted MI group (101 min vs. 220 min, p < 0.00001). Patients with aborted MI had a lower corrected TIMI frame count (p < 0.05) and a lower wall motion score index (p < 0.005), less pronounced inflammatory response (lower serum levels of IL-6, p < 0.01, and MCP-1, p < 0.05), higher ejection fraction six months after MI (72% vs. 64%, p < 0.05). None of the aborted MI patients died during the 3-year follow-up, while there were 13 deaths among patients with non-aborted MI.Conclusions. The abortion of myocardial infarction results in a better outcome and more favorable prognosis. An inflammatory response is less pronounced in the aborted MI.
Institutions of health’s care. Aspects European and judicial
Authors: Stępniak Piotr
Published: April 2021

Present paper is then a part of a trend to find the premises for the theory’s construction. I will try to combine the point of view presented by social sciences, criminology and medical sciences, what will become a starting point for analysis and in further perspective – for research on some theoretical models.
Research Progress on Habitat Connectivity in Temperate Waters
Authors: Gao Shike , Yu Wenwen , Li Zhen , Zhang Shuo , Fu Kang , Wang Nuo , Gu Jun
Published: April 2021

Ecological connectivity, as a research method related to spatial ecology and conservation biology, has attracted increasing attention from researchers at home and abroad in recent years. Habitat connectivity, as a key link in ecological connectivity, is of great significance to promote offshore ecological restoration and protection. However, there has been less systematic research about habitat connectivity, which lacks corresponding theories and practices. Therefore, this paper discusses habitat connectivity from three aspects: (1) the concept of habitat connectivity is introduced and clarified, (2) the application of connectivity in artificial habitat and adjacent waters and its relationship with biodiversity conservation are reviewed and illustrated with examples, and (3) the future development trends of this research direction are summarized and prospected, in order to provide a scientific basis and useful reference for the related work of offshore restoration projects in China. Generally, this paper argues that an increase in human behavior irreversibly destroys the connectivity of marine habitats and threatens the temporal scales of biodiversity and ecosystem services. Therefore, the theoretical research results and practical experience of ecological connectivity should be fully applied to marine ecosystems, and the restoration of degraded ecosystems should be encouraged and supported in ways that promote natural recovery.
A Solution of the Cosmological Constant and DE and Arrow of Time, Using Model of a Nonsingular Universe from Rosen from Volume (56) Ettore Majorana International Science Series, Physics, 1991
Authors: Beckwith Andrew W.
Published: April 2021

We reduplicate the Book “Dark Energy” by M. Li, X-D. Li, and Y. Wang, given zero-point energy calculation with an unexpected “length’ added to the ‘width’ of a graviton wave just prior to specifying the creation of ‘gravitons’, using the Rosen and Israelit model of a nonsingular universe. In doing so we are in addition to obtaining a wavelength 10^30 times greater than Planck’s length so we can calculate DE, may be able to with the help of the Rosen and Israelit model have a first approximation as to the arrow of time, and a universe with massive gravity. We have left the particulars of the nonsingular starting point undefined but state that the Rosen and Israelit model postulates initial temperatures of 10^-180 Kelvin and also a value of about Planck temperature, at 10^-3 centimeters radii value which may satisfy initial conditions asked by t’Hooft for describing an arrow of time. A key assumption is that the DE is formed at 10^-3 cm, after an expansion of 10^30 times in radii, from the Planck length radius nonsingular starting point. The given starting point for DE in this set of assumptions is where there is a change in the cosmic acceleration, to a zero value, according to Rosen and Israel, with time t = 1.31 times 10^-42 seconds. Which may be where we may specify a potential magnitude, V, which has ties into inflaton physics. The particulars of the model from Rosen and Israelit allow a solution to be found, without discussion of where that nonsingular starting point came from, a point the author found in need of drastic remedies and fixes.
Study of Differences in Motor Reactions and Performances in Professional Ice Hockey Players and not Experienced Participants Using Virtual Reality (VR) Technology
Authors: Polikanova Irina , Yakushina Anastasiya , Leonov Sergey , Kruchinina Anna , Chertopolokhov Victor , Liutsko Liudmila
Published: April 2021

The efficiency of performance in various sports has the development of certain specific skills at its core. In ice hockey, both the technical aspects (techniques, stance) and the cognitive ones (keeping attention on the puck, game strategy, etc.) are highly important. This study is aimed at the identification of specific features that determine the performance efficiency of professional hockey players. We used virtual reality (VR) to study the differences between professional ice hockey players and novices in terms of motor responses to the puck’s presentation on different levels of difficulty. The study involved 22 participants, 13 of them being professional ice hockey players (Mage=20±2.9; mean age of training experience М=14.18±3.8) and 9 being not experienced participants (Mage=20±1.4). The study showed that the stick response time of professional hockey players is significantly higher (0.98 ms vs 1.5 ms, p≤0.05) in more difficult situations close to a real game. Moreover, professionals proved to have more stable movement patterns of the knee and hip joints. They also make fewer head movements as a response to stimuli during all runs (0.66 vs 1.25, p≤0.05). Therefore, the results indicate specific spatial-temporal, technical and tactical, and energetic determinants, that ensure higher performance efficiency in hockey players
Efficient Intravenous Tumor Targeting Using the αVβ6 Integrin Selective Precision Virotherapy Ad5NULL-A20
Authors: Davies James A , Marlow Gareth , Uusi-Kerttula Hanni K , Seaton Gillian , Piggott Luke , Clarkson Richard W. E. , Chester John D , Parker Alan L.
Published: April 2021

Background: We previously developed a refined, tumor selective adenovirus, Ad5NULL-A20, har-boring tropism ablating mutations in each major capsid protein, to ablate all native means of infection. We incorporated a 20mer peptide (A20) in the fiber knob for selective infection via αvβ6 integrin, a marker of aggressive epithelial cancers. Methods: To ascertain the selectivity of Ad5NULL-A20 for αvβ6 positive tumor cell lines of pancreatic and breast cancer origin, we performed reporter gene and cell viability assays. Biodistribution of viral vectors in mice harboring xenografts with low, medium, and high αvβ6 levels was quantified by qPCR for viral genomes 48 hours post intravenous administration. Results: Ad5NULL-A20 vector transduced cells in an αvβ6 selective manner, whilst cell killing me-diated by oncolytic Ad5NULL-A20 was αvβ6 selective. Biodistribution analysis following intrave-nous administration into mice bearing breast cancer xenografts demonstrated that Ad5NULL-A20 resulted in significantly reduced liver accumulation coupled with increased tumor accumulation compared to Ad5 in all three models, with tumor: liver ratios improved as a function of αvβ6 expression. Conclusions: Ad5NULL-A20 based virotherapies efficiently target αvβ6 integrin positive tumors following intravenous administration, validating the potential of Ad5NULL-A20 for systemic ap-plications, enabling tumor selective overexpression of virally encoded therapeutic transgenes.
Flexible Smart Textile Coated by PVDF/Graphene Oxide With Excellent Energy Harvesting Toward a Novel Class of Self-Powered Sensors: Fabrication, Characterization and Measurements
Authors: Chakhchaoui Nabil , Farhan Rida , Chu Yu-Ming , Khan Umair , Eddiai Adil , Omari Lhaj El Hachemi , Meddad Mounir , Hajjaji Abdelowahed , Cherkaoui Omar , Boughaleb Yahia , vanlangenhove Lieva
Published: April 2021

Because of some of their diverse benefits, intelligent textiles have attracted a great deal of interest among specialists over the past decade. This paper describes a novel approach to the manufacture of intelligent piezoelectric polymer-based textiles with enhanced piezoelectric responses for applications that extract biomechanical energy. Here we report a highly scalable and ultrafast production of smart textile piezoelectric containing graphene oxide nanosheets (GONS) dispersed in polyvinylidene fluoride (PVDF). In this work, Cotton textiles (CT) were functionalized and by graphene oxide (GO), using PVDF as a binder to obtain a CT-PVDF-GO material. Tetraethyl orthosilicate (TEOS) was further grafted as a coating layer to improve the surface compatibility, resulting in the CT-PVDF-GO-TEOS composite. The research results show that the addition of GONS significantly improves PVDF's overall crystallization rate on CT. More specifically, the piezoelectric β-phase content (100 % higher F[β]) and crystallinity degree on the piezoelectric properties of composite cotton fiber has been improved effectively. Consequently, this fabricated piezo-smart textile has a glorious piezoelectricity even with comparatively low coating content of PVDF-GONS-TEOS. Based on it, the as-fabricated piezoelectric textile device has resulted in the output voltage of up to 13 mV for a given frequency (fm = 8 Hz) at fixed strain amplitude value (0.5 %). It is believed that this research may further reveal the field of energy harvesting for possible applications in the future.. In addition, the set of experimental results that illustrate the smart textile was carried out and discussed, and how it can be used as a wearable device source for this smart textile. Finally, the approach described in this study can also be used to construct other desirable designs, for a wearable low-consumption sensor, etc.
Fractional Line Integral
Authors: Bengochea Gabriel , Ortigueira Manuel
Published: April 2021

This paper proposes a definition of fractional line integral, generalising the concept of fractional definite integral. The proposal replicates the properties of the classic definite integral, namely the fundamental theorem of integral calculus. It is based on the concept of fractional anti-derivative used to generalise the Barrow formula. To define the fractional line integrals the Gr\"unwald-Letnikov and Liouville directional derivatives are introduced and their properties described. The integral is defined first for broken line paths and afterwards to any regular curve