bluuebunny/crossref_metadata_2025 huggingface dataset:
MINIMISATION OF RISKS ASSOCIATED WITH THE USE OF POLLEN-BASED MEDICINES, AT THE STAGE OF POLLEN COLLECTION
Authors: Taube A. A. , Buyanova T. A. , Sakanyan E. I.
Published: May 2022

The aim of the study is the elaboration of Rules for Harvesting/Collecting of Pollen to minimize the risks associated with the use of pollen-based medicinal products.

Materials and methods. The following electronic resources were used in the study: PubMed, Medline, ScienceDirect, Web of Science, Scopus, Google Scholar, eLibrary, World Allergy Organization, Cochrane Database, Stallergenesgreer, Allergenscienceandconsulting, Pharmacopoeia, Fda.gov, fs.usda.gov, Ema.europa.eu. The analysis covered the period from January 1, 2010 until December 31, 2021.

Results. Currently, there are some general requirements for the quality of pollen in Russia, but there are no controls or standardised procedures for harvesting, drying, and purification of pollen. The USA and EU also lack established qualification programmes for pollen-collecting companies and/or individual pollen collectors. Regulatory authorities establish requirements only for visual control of raw materials or delegate responsibility to the manufacturer. The analysis of the existing regulatory documentation revealed lack of requirements for collection, storage, and processing of pollen used as the raw material for the production of allergen products. This calls for the elaboration of appropriate regulatory documents. The authors have compiled the Rules for Harvesting/Collection of Pollen, which include 6 parts. The Rules are intended for individuals directly involved in harvesting/collection of pollen, and contain requirements for pollen collectors, the process of pollen collection, documentation, storage, and transportation.

Conclusion. The authors have prepared the Rules for Harvesting/Collecting of Pollen, which include 6 parts. The Rules cover the whole process of pollen collection and all related processes. The implementation of this document will improve the process of pollen collection, thus reducing the risks associated with the use of pollen-based medicines. Further studies will assess the impact of the pollen quality on the safety of medicinal products.
GENDER CHARACTERISTICS OF ADVERSE DRUG REACTIONS DEVELOPMENT: EXPERIENCE OF REGIONAL DATABASE ANALYSIS
Authors: Matveev A. V. , Krasheninnikov A. E. , Egorova E. A. , Konyaeva E. I. , Matveeva N. V.
Published: May 2022

The aim of the article is the gender characteristics study of the adverse drug reactions (ADRs) development based on the data of the notification forms registered in the regional database ARCADe (Adverse Reactions in Crimea, Autonomic Database), for the period from 2009 to 2018.

Materials and methods. The objects of the study were 6903 notification forms about adverse drug reactions recorded in the regional database called ARCADe (Adverse Reactions in Crimea, Autonomic Database) for the period from 2009 to 2018. The classification of drugs for separate pharmacological groups was carried out using the codes of the Anatomical Therapeutic Chemical (ATC) classification system of the World Health Organization (WHO) medicinal products, the instructions data of the State Registers of medicinal preparations used in the Russian Federation and Ukraine (for the cases registered before the entry of the Republic of Crimea into the Russian Federation).

Results. A general analysis of the number of cases of the adverse drug reactions (ADRs) development in patients of different genders made it possible to determine that 59.9% (4132 notification forms) of ADRs cases were observed in female patients; 37.7% (2602 cases) – in male patients. In 169 cards (2.4%), information about a patient’s gender was missing. The groups with the largest number of the registered cases of ADRs were antimicrobial agents for a systemic use (2864 cases, 41.5% of the total number of the ADRs registered cases), the drugs affecting the cardiovascular (811 cases, 11.7%) and nervous (734 cases, 10.6%) systems. In each of the presented groups, the incidence rate of ADRs in female patients exceeded that in men.

Conclusion. The study of the gender characteristics of the pharmacotherapy safety, carried out on the basis of the notification forms of the ADRs data registered in the Republic of Crimea, confirmed a higher likelihood of developing ADRs in female patients. This may be due to the peculiarities of the pharmacokinetics and pharmacodynamics of drugs in the female body, psychological factors, a more frequent use of drugs by this category of people. The implementation of the drug, taking into account specific features of each gender, can lead not only to better treatment outcomes, but also to increased patients’ compliance.
Transformation of cultural and educational programs on television in a pandemic context (on the example of the project “Russian Museum. 125 years old”)
Authors: Ilchenko Sergey N. , Razina Olga A.
Published: May 2022

We are considering the experience of a regional TV broadcaster in covering a major cultural event. The authors are of particular interest to the process of transforming cultural and educational projects in the difficult conditions of informational and organizational restrictions associated with the pandemic period.
Advertising language: structural features of advertising texts
Authors: Pyadysheva Tamara G.
Published: May 2022

The relevance of this work is as follows – the studies conducted in this field reflect the fact that the language of advertising is quite rich, especially structural components. The unity of verbal, graphic, audiovisual aspects is an integrity that can somehow be represented in the form of a text message. The object of the study is the language of advertising, the subject of the study is what is its influence on the structural features of advertising texts. Formulating the objectives of the study, it is fair to ask such questions: what is advertising in principle? What is the language in which it “speaks”? And what are its forms and structural features? Is the difference in advertising texts significant by type of communication, etc. The objectives of the study are to visually reflect the role of the presence of advertising in modern times, to understand the basic terminology, to highlight what goals the advertising text pursues, to establish what are the structural features of various advertising texts. The research methods in this scientific work are theoretical and scientif-ic-literary analysis, bibliographic analysis of conference collections and materials posted on the Internet. The analyzed information of scientific literature made it possible to draw a theoretical conclusion – the structural features of such PR-texts as a press release, an advertising interview, a background, and the practical conclusion of this research work are revealed – an applied opportu-nity to use the generalized material of this work.
The role of morphonological elements in the abstract nouns word formation with the suffix -ost’ (-est’)
Authors: Im Svetlana B.
Published: May 2022

The issue of morphonology status and units of its description remains relevant in modern linguistics. The purpose of study is to describe the morphonological rules for choosing suffix
-ost’ (-est’), to investigate the hierarchies of morphonological units that determine the synthesis of the sound structure of derivatives under study, consisting of a set of stress morphonemes, pho-nemes alternation and allomorphs alternation. We mainly use the descriptive method, which in-cludes such techniques as observation, comparison, juxtaposition, generalization, interpretation. Based on the description, we conclude that word formation of considered class of words is distin-guished by fusion, and not agglutination. The choice of an allomorph depends on morphological characteristics of generator, and allomorph determines the stress and the type of derivative's alter-nant, that is, the morphological unit includes phonemes alternation, stress alternation and allo-morphs alternation of the suffix, which are 3 morphonological units. The results of study, in par-ticular, the significance of suffix in describing the theoretical foundations for describing the mor-phonological phenomena of Russian language, as well as the model of morphonological descrip-tion of Russian word formation, make a certain contribution to the development of morphonology as an independent science. The practical significance lies in the fact that the conclusions and materials of study can be used in the compilation of special morphonological dictionaries.
Aesthetic image of Turkic paremic unit
Authors: Eskeyeva Magripa K. , Mussabekova Urzada A.
Published: May 2022

The work is devoted to understanding the aesthetic assessment on the basis of Turkic proverbs and sayings. We consider linguo-philosophical judgments about beauty, which are included in the content of proverbs and sayings in the modern Kazakh language. We establish that proverbs and sayings, being complex linguistic units, express a holistic conceptual thought. They occupy a special place among the topical problems of Turkic linguistics. It is established that Turkic proverbs and sayings reflect an indicator of aesthetic taste, the desire to know themselves, the environment and form a base of practical knowledge that determines the spiritual values of each member of the ethnic group, differentiating being from the point of view of aesthetic values, which include the best qualities and important life attitudes. in cognition, the culture of the ethnic group.
Dialect lexicography of the Russian language at the beginning of the 21st century
Authors: Matijiv Nikolay D.
Published: May 2022

We analyze the dialect lexicographic situation in Russia at the beginning of the 21st century: dictionaries of different genres are highlighted, publications of specific regions and districts are grouped, – both collective and individual works. In general, a brief systematic review of 87 (very large, large, medium and small) dialect lexicographic works is given. We note that the di-alectography of recent decades is represented mainly by traditional differential dictionaries, which differ from the literary standard, and less often by non-differential, full-type dictionaries; it has been supplemented with 9 thematic dictionaries; 5 – idiolect dictionaries; 2 dictionaries of dialect vernacular; motivational dictionary of subdialect; figurative units of dialect; emotional-evaluative vocabulary of dialects; 7 phraseological dictionaries of dialects. Of the 87 dictionaries, 4 are ongoing (unfinished) issues, volumes of works published since the second half of the 20th century; 11 are completed (published) dictionaries, work on which was started in the late 90s of the twentieth century; 65 are published editions from 2001 to 2021 (4 dictionaries of which were published decades after compilation, 2 are additions to previously published works, 10 dictionaries are corrected and supplemented; 7 continue to be published). New lexicographic works almost completely cover the map of Russian dialects.
Verbalization of image of an apple tree in V.A. Soloukhin’s poetry
Authors: Kushnir Ksenia I.
Published: May 2022

We analyze linguistic features of poetic texts by V.A. Soloukhin, included in the collection “Poems” (1990). The subject of research is the image of an apple tree from the point of view of the specifics of its verbalization in the individual author’s picture of the world by V.A. Soloukhin in comparison with the linguistic embodiment of the image of an apple tree in the linguistic picture of the world of Russian people. The relevance of research lies in the fact that V.A. Soloukhin’s poetic picture of the world is analyzed from various linguistic and cultural positions, which is associated with the ability of a lexeme to absorb both ethnocultural information and individual author’s information. The purpose of study is to comprehend the role of the dendronym apple tree in the author’s work as a carrier of figurative folklore and mythological meanings. The image of a tree is considered in the context of the manifestation of the Russian mentality, culture and history. The study may have a practical focus in the teaching of Russian, including Russian as a foreign language; when studying the creativity of V.A. Soloukhin in the literary course and in the compilation of author’s dictionaries. It is concluded that the apple tree in the artistic picture of the world of V.A. Soloukhina is inextricably linked with the image of the Russian garden. The author, associating the concept of life and death with the apple tree, recalls the harm that a person can cause to wildlife, and by including in his works lexemes describing the flowering of an apple tree, the beauty of its fruits, wilting of leaves, coarsening of trunks and roots, he shows cyclicality life not only of a tree, but also of a person.
English loanwords in Chinese in the field of blockchain
Authors: Trusov Egor V. , Andrakhanov Andrey A. , Mitchell Peter J.
Published: May 2022

Nowadays, blockchain attracts the attention of more and more scientists. This is due to the high interest of the world community in this topic, the high pace of development of blockchain technology and its introduction into the life of society in the 21st century. It is worthwhile noting that blockchain technology is important for the future of humanity, because it allows people to build trust. Trust will be built in every area in the finances, real estate, healthcare, business and other life areas of society. Owing to the great prospects for the development of this technology, the attention of linguists is attracted by the fact of the appearance of lexical formatives connected with blockchain. First of all, loanwords are the transition of elements of one language to another as a result of the interaction of languages, or the elements themselves transferred from one language to another. Due to the fact that works about the blockchain initially appeared in English, the lexical units of this topic came to Chinese from English. We provide a classification and also determine the most common ways of loanwords from English to Chinese in blockchain. The relevance of study is determined by the lack of knowledge of English loanwords in Chinese in the field of blockchain. When training specialists in translation, the topic of blockchain remains understudied, due to the difficulties in translation terminology. Thus, studying loanwords can improve the skills of translators, help them avoid mistakes when translating from English to Chinese and vice versa.
Impact of digitalization on the conservation of valuable species of animals
Authors: VLASOVA Elena L. , USTYANTSEVA Olga V.
Published: May 2022

The relevance of the research topic is due to the intensification of the process of introducing digital technol-ogies into the life of society. The digital transformation of the ecological sphere affects the state of environment and exacerbates the issues of protecting human environment and preserving biological diversity. The choice of topics is explained by the fact that individual representatives of the wild fauna are economically valuable re-sources of conditionally free nature, this attracts criminal communities to the development of the digital envi-ronment and the development of illegal trading networks. The methodology of study, along with general scientific methods, includes specific scientific ones: with the help of the statistical method, quantitative indicators are added to the legal analysis of encroachments on wild animals using the Internet; the culturological method made it possible to identify the influence of the information environment on law-making activities that prevent cybercrime. In the course of studying the topic, special attention was paid to the trade in valuable wild animals in the digital environment and it was found that the trade in wild animals poses a threat to national security, leads to the loss of biodiversity, increases corruption, improves cybercrime technologies, and contributes to the commission of other anti-social acts and deterioration of public health. The formulated proposals for improving the national legislation in terms of the circulation of valuable wild animals are aimed at preserving biodiversity.
Correlation of legality principle and parties’ equality principle in the claim proceedings
Authors: MEHRABYAN Samvel A.
Published: May 2022

We consider the relationship between legality principle and parties’ equality principle in the claim proceed-ings. We believe that the basis for ensuring the actual implementation of this principle is a correct understanding of the interdependence of these principles. We focus special attention on the interdependence of legality and equality of the parties, which in absolute terms can be regarded as a sign of complementarity. We aim to analyze the relationship between legality principle and parties’ equality principle in the claim proceedings. Tasks: to study the concept and significance of the principle of “legality” and “equality”, to consider the problems of implementing these principles of the Code of Civil Procedure of the Russian Federation, to propose improvements for the process of implementing these principles in the Code of Civil Procedure of the Russian Federation. We establish that the reason for non-compliance with certain requirements, leading to the abandonment of the statement of claim, may be the unfair (un) intentional activities of some interested parties. Our contribution to the study is to identify a procedural defect in Article 147 of the Code of Civil Procedure of the Russian Federation. This article does not directly contain a prohibition for the court at the stage of preparation for the court session, to hold a court session without proper notification of the parties, which is a violation of the principles of legality and equality of the parties in the proceedings. On this basis, we consider it possible to correct and (or) supplement Article 147 of the Code of Civil Procedure of the Russian Federation with part 3. The need for these changes is justified by the importance of ensuring real equality of parties.
The main aspects characterizing the crime disclosure concept
Authors: POTAPOV Sergey A.
Published: May 2022

The relevance is due to a comprehensive study of the meanings of the criminal procedural, forensic and op-erational-investigative concepts of crime disclosure. The purpose of work is to analyze the above concepts and establish their significance for solving the problems of criminal justice. Realization of the goal is achieved by us-ing the laws of dialectics, formal logic and the use of general scientific and private scientific research methods. We explore the genesis of the origin of these concepts, their characteristic features, relationship of concepts both among themselves and with the concept of crime investigation. We define and study the criminal procedural concept of the crime disclosure in relation to the concept of its investigation. We conclude that in this case the contents of these concepts coincide, and the concept of crime disclosure loses its scientific significance. The fo-rensic concept of crime disclosure is of great scientific, methodological and practical importance for the crimes investigation. We consider it as the initial stage of the investigation, without which it is impossible to achieve its ultimate goal. We study the operational-investigative concept of crime disclosure, which is legally fixed as one of the main tasks of Operational-Investigative Activity. We study the main features of crime disclosure concept, ways to increase its effectiveness are identified. We conclude that the crime disclosure concept is a forensic and operational-investigative category that has great scientific, methodological and practical significance for solving the problems of criminal proceedings.
Cultural construction in gender studies in Brazil
Authors: Hora Juliana Figueira , Diogo Ligia Baruque
Published: May 2022

This article has the objective of discussing Gender Studies and its cultural construction in Brazil, alongside Heritage Studies. We have chosen to bring to the fore the women artisans of Jequitinhonha Valley because this case study brings essential elements about the construction of female and male local identities in a fluid point of view connected with social, cultural, historical heritage, space and craft issues. The ceramist women of the region let us notice the elastic element in identities that are not marked at all. The exchange of social and gender roles is constant, regardless of the much crystalized "community pater familias” that consolidates sex as a determinant of well-marked and sectorized functions. In the case of artisan ceramist women of Jequitinhonha region, there are breakings of paradigms, boundaries, asymmetrical barriers, function, craft, and gender construction, oscillating between the paternalist traditionalism of fixed functions and the fluid and dynamic social system of the daily economic demands.
Empoderamento feminino e impactos do turismo em Magdalena de Cao
Authors: Pagnossi Nádia Carrasco
Published: May 2022

Esse artigo visa apresentar os resultados parciais de uma série de entrevistas feitas a mulheres da comunidade de Magdalena de Cao (Costa Norte do Peru), buscando entender o empoderamento feminino gerado a partir da figura da líder Moche, Señora de Cao, nos últimos anos. Também são discutidos os impactos do turismo ocorridos na cidade, tanto na alteração do espaço urbano, quanto nas relações econômicas e sociais, em especial nas de gênero.
Territorialidade queer
Authors: Silva Áureo Rosa da
Published: May 2022

A cidade contemporânea é objeto constante de estudos e reflexões interdisciplinares no ambiente acadêmico e informal no que diz respeito ao fenômeno da decadência dos centros urbanos. Goiânia viu ascender esse processo de forma rápida e devastadora, por se tratar de uma cidade planejada e nova em relação à outras capitais, seu centro entrou em decadência rapidamente, principalmente no período noturno. Os pontos de resistência alavancam um resquício de movimento na região através dos "usos clandestinos", nos quais destacam-se locais em que é identificável uma possível lógica de gênero em suas ocupações. O foco das seções seguintes se concentram na formulação teórica do termo-título: Territorialidade Queer, relatando seus aspectos fundamentais para a compreensão do que hoje apresenta características de uma ocupação territorial no centro de Goiânia, com breve análise de um destes territórios: o Cine Astor, através de um olhar sensível à questão de gênero, ressaltando a atuação do urbanismo na produção e controle dos corpos abjetos
A construção de narrativas e os estudos de cultura material
Authors: Agostini Camilla , Baggio Enrico
Published: May 2022

A Arqueologia cresce em possibilidades na interface com os Estudos de Cultura Material, particularmente ao se aproximar de tempos mais recentes. O processo de construção de narrativas a partir das coisas é um domínio que pode ser aprofundado, do ponto de vista das linguagens, bem como do seu papel no processo de produção do conhecimento. O estudo tanto da construção de narrativas, quanto a aproximação aos Estudos de Cultura Material se mostram terreno fértil para pesquisadores, bem como campo em experimentações para estudantes de graduação. Nesse artigo desenvolvemos o potencial de exercícios de construção de narrativas a partir de práticas interdisciplinares com estudantes de graduação, especialmente em atenção a relação das coisas com as pessoas e os espaços. É apresentada também uma breve reflexão sobre a aproximação da arqueologia com a literatura. Nesse caso, trazemos para a cena Howard Philips Lovecraft e sua literatura Fantástica de Horror, observando como ela conversa e nos faz pensar sobre os estudos das coisas do passado.
Os cursos de arqueologia nas regiões nordeste e sudeste do Brasil e o seu viés social e material
Authors: Monteiro Gabriela
Published: May 2022

A Arqueologia brasileira vem passando por uma nova fase em todos os seus campos: teóricos, metodológicos, temáticos e normativos. Nesta nova caminhada está sendo colocada, persistentemente, em pauta a importância de uma efetiva inclusão das sociedades atuais nas pesquisas, em oposição a um caráter mais tecnicista que sempre prevaleceu nesta ciência. À vista disso, será apresentado o contraste entre esse viés material e social, tendo como plano de fundo uma série de dados sobre os cursos de Arqueologia das universidades e faculdades do Nordeste e Sudeste – regiões nas quais estão situados os cursos mais antigos do país. A partir desses dados, pôde-se confirmar que alguns cursos estão assumindo um viés mais social em contraponto a sua origem histórica, em razão de uma demanda, sobretudo, dos alunos de graduação e das novas abordagens que vêm surgindo em todas as ciências humanas.
Quality of Life of Chronic Hepatitis B Patients Consuming Nucleoside Analog: A Case-Control Clinical Study in Indonesia
Authors: Putri Natasya Ariesta Selyardi , Aswin R. Haryanto , Fithriyah Izzatul , Maimunah Ummi , Miftahussurur Muhammad , Yamaoka Yoshio
Published: May 2022

Introduction: Chronic hepatitis B raises serious concern due to its high morbidity, such as cirrhosis and hepatocellular carcinoma, and mortality from 267 per 100,000 person-years. Up to now, medical therapy that successfully eradicates the hepatitis B virus is not available. Therapy is given in the long term for suppressing viral replication and disease progression. Nucleoside analog (NA) is a medication that is consumed orally once a day for years. Previous studies showed that patients who were treated with NA had a different quality of life (QoL) compared to naïve patients. This research aimed to analyze the QoL of chronic hepatitis B patients who consumed NA by comparing it with naïve patients at Dr. Soetomo General Academic Hospital Surabaya. Methods: Subjects were recruited consecutively from chronic hepatitis B patients at Dr. Soetomo General Academic Hospital Surabaya during 9 February – 31 May 2021. Data about sociodemographic characteristics, hepatitis B therapy history, and QoL were gained by using the SF-36 questionnaire and medical records. Subjects were divided into NA and naïve groups which responses underwent an analytical comparison. Results: NA group had significantly higher QoL in a physical component score (PCS) and mental component score (MCS), with physical functioning (PF), role limitations due to physical health (RP), role limitations due to emotional problems (RM), energy/fatigue (VT), emotional well-being (MH), social functioning (SF), and general health perception (GH) subscales having p<0.05Conclusion: The QoL of patients who were treated with NA was significantly higher than that of naïve patients in terms of physical and mental components.
The Potential of Cammelia sinensis (Tea Leaves) Active Compound as Alternative Therapy on castrate-resistant prostate cancer (CRPC) with Androgen Receptor Inhibition: In Silico Study
Authors: Putra Mega Memory Rahasa , Seputra Kurnia Penta
Published: May 2022

Introduction: Prostate cancer is a leading global cause of increased mortality and morbidity in men which can be complicated by castrate-resistant prostate cancer (CRPC). Pharmacological therapy by inhibiting the androgen receptor (AR) can inhibit prostate cancer progression. Tea leaves (Camellia sinensis) are believed to inhibit the prostate cancer progression but the mechanism is still unknown. Therefore, research on the mechanism by in silico study is needed with the AR as target protein.Methods: The effectivity of tea leaves’ active compound to inhibit androgen receptor was evaluated by docking server with abiraterone acetate as a control. The tea leaves' active compounds consist of catechin, epicatechin, epigallocatechin gallate, epigallocatechin, gallate epicatechin, gallocatechin gallate, and gallocatechinResults: The result showed that epicatechin, epigallocatechin, and gallocatechin have lower free binding energy (ΔG) and high amino acid residue similarity on AR compared with abiraterone acetate. But, it has lower surface interaction compared with abiraterone acetate. Conclusion: Epicatechin, epigallocatechin, and gallocatechin are predicted to have potential as alternative therapy in CRPC with AR Inhibition.
Profile of Dengue Fever Complication in Infant at Tertiary Referral Hospital in East Java, Indonesia
Authors: Khen Mikhael  , Husada Dominicus , Lestari Pudji
Published: May 2022

Introduction: Dengue virus infection is caused by the dengue virus and transmitted through the bites of infected Aedes aegypti or Aedes albopictus mosquitoes. The spectrum of clinical manifestations is varied from asymptomatic, undifferentiated fever, dengue fever, dengue hemorrhagic fever, dengue shock syndrome, to expanded dengue syndrome. Data from 2016 in Indonesia revealed that dengue virus infection is common in the population, with a total of 333.821 cases of dengue hemorrhagic fever. Methods: This was a descriptive study with a cross-sectional design. The subjects in this study were children under 1-year-old, diagnosed with dengue virus infection, and had a complication. The number of subjects used is 60 infants. Results: Infection of dengue virus in infants is often found in the 7-9 month age group (36,6%). Clinical manifestations found were fever (100%), vomiting (62%), diarrhea (43%), petechiae (22%), bleeding (12%), and irritable (5%). Thrombocytopenia and leukopenia were found in 93,3% and 26,6% of infants respectively. Complications were found in the form of pleural effusion (66%), hypoalbuminemia (62%), hyponatremia (51%), liver involvement (49%), hypocalcemia (43%), hypokalemia (23%), bleeding (21%), brain involvement (21%), kidney involvement (13%), and ascites (11%).Conclusion: The most common clinical manifestations are fever, diarrhea, and vomiting, while the most common complications are pleural effusion, hypoalbuminemia, hyponatremia, liver involvement, and hypocalcemia.
The Effect and Mechanism of Sucrose Consumption to Liver Disease – A Systematic Literature Review
Authors: Sim Hellene Anjani Sigma
Published: May 2022

Introduction: One liver disease caused by excessive fat in the liver, called non-alcoholic liver disease (NAFLD), commonly occurs with obesity, diabetes, and other disorders. NAFLD is also associated with hepatic insulin resistance, steatosis, non-alcoholic steatohepatitis (NASH), and cirrhosis. Sucrose consumption has increased recently, and known can promotes NAFLD and will accelerate NAFLD development. This study aimed to discuss the effect and mechanism of sucrose intake on liver disease using a systematic literature review.
Methods: The author identified the articles from 6 online search engines, including PubMed, Science Direct, Sinta, Garuda, Google Scholar, and EBSCOHost. A total of 2271 retrieved articles were obtained from combined search strings in Indonesian and English from the search through online search engines. Excluded articles include title not relevant, duplicate articles, not open access, secondary study or review articles, research objective not appropriate, abstract not suitable, and the results/findings not relevant to the aims of this paper.
Results: A final of twenty-three articles were retrieved using the Mendeley reference manager. Studies included were published studies, types of experimental and observational studies, and their specific findings of sucrose effects on liver disease. Results reveal that most research was primarily conducted experimentally and in case-control study types on male rats.
Conclusion: The most common disease related to sucrose is NAFLD, fibrosis/cirrhosis with the indication of NASH, obesity, insulin resistance (IR), triglycerides (TG), hepatic steatosis, hepatocyte ballooning, and weight gain, which we will discuss further in this review.
Relationship between Sarcopenia in Abdomen CT Scan Results with C-Reactive Protein Level in Colorectal Cancer Patients at Dr. Soetomo General Academic Hospital Surabaya
Authors: Erlyta Dian Puspitarini  , Prijambodo Prijambodo
Published: May 2022

Introduction: Colorectal cancer is the third most malignant and the fourth-largest cause of death in the world, one of which is caused by cachexia cancer. Sarcopenia is the main diagnostic criterion for cachexia. The inflammatory response, one of the markers of which is C-Reactive Protein (CRP), is also involved in the occurrence of sarcopenia associated with cachexia cancer. This study aimed to determine the occurrence of sarcopenia and its relationship with CRP preoperative colorectal cancer patients. Methods: This type of observational retrospective analytic study assessed sarcopenia based on the Psoas muscle index (IOP) on preoperative CT scan images and CRP levels measured by an integrated automatic tool Dimension RxL Max with Flex liquid reagent preoperative CRP range (RCRP). Results: Sarcopenia occurs in male colorectal cancer patients with a p-value of 0.001<0.05 (5%) with an IOP mean value of 26.75 m2, while in female patients the IOP mean value was 21.33 m2, it does not occur sarcopenia with p-value 0.583>0.05 (5%). There was an increase in CRP in 62.5% of colorectal cancer patients, but the relationship between IOP values and CRP values of colorectal cancer patients was still categorized as weak with p value of -0.387 in men and -0.046 in women with α=0.05. Conclusion: There was a nonsignificant relationship between sarcopenia and CRP levels in colorectal cancer patients. Further prospective studies are required to consider the indicators of sarcopenia besides the decrease in IOP and identification of confounding factors known to be associated with CRP, muscle strength, and muscle mass.
Diathesis Hemorrhagic, Coagulation and Fibrinolytic System
Authors: Rizky Amalia Putri  , Muhammad Noor Diansyah  , Ashariati Ami Ashariati , Siprianus Ugroseno Yudho Bintoro  , Putu Niken Ayu Amrita  , Savitri Merlyna Savitri , Pradana Zaky Romadhon
Published: May 2022

Bleeding is one of the most common complaints when coming to the hospital which can be mild to life-threatening. The balance of the impaired hemostasis system allows for abnormal bleeding such as hemorrhagic diathesis. Balance between blood clotting and bleeding is always maintained in the body under normal physiology. The coagulation system stops existing bleeding with vasoconstricts of blood vessels and the formation of early platelet plugs, this blockage is strengthened by the presence of a cascade of coagulations to form stable and sturdy blockages. Once bleeding has stopped, the fibrinolytic pathway is initiated to dissolve the blood clot to restore normal blood flow. balance the coagulants, fibrinolytic and inhibitor systems, creating a perfect physiological balance. Hemostatic imbalance is a global problem that can lead to thrombosis or hemorrhage.
Pengecualian Objek Pajak Penghasilan Wajib Pajak Badan Atas Dividen
Authors: Wafikhoh Inas Syadza
Published: May 2022

AbstractCurrently, the largest state revenue comes from the tax sector, and the income tax sector is a strategic sector to increase state revenue. One of the objects of income tax is dividends. Income tax is imposed on every additional economic received by the taxpayer. One of the subjects subject to income tax is a domestic entity called a domestic corporate taxpayer. Taxpayers who receive dividends are burdened with the obligation to pay income tax. Dividends are a type of income obtained from company profits that provide additional economic benefits. It turns out that the imposition of tax on dividends gives rise to double taxation, if more than one person is taxed on the same type of income. The imposition of double taxation can lead to tax avoidance. So in order to minimize the existence of this double tax, in the tax regulations there are exceptions to the type of income tax object which is strictly regulated in order to minimize the existence of double taxation.Keywords: Income Tax; Dividend; Double Taxation.
AbstrakSaat ini pendapatan terbesar negara datang dari sektor pajak, dan sektor pajak penghasilan menjadi sektor strategis guna meningkatkan pendapatan negara. Salah satu objek pajak penghasilan adalah dividen. Pajak penghasilan dikenakan pada setiap tambahan ekonomis yang diterima oleh Wajib pajak. Subjek yang dikenakan pajak penghasilan salah satunya adalah badan dalam negeri yang disebut dengan wajib pajak badan dalam negeri. Wajib pajak yang mendapatkan dividen dibebani kewajiban untuk membayar pajak penghasilan Dividen merupakan jenis penghasilan yang didapatkan dari laba perusahaan yang memberikan tambahan ekonomis. Ternyata pengenaan pajak atas dividen, menimbulkan adanya pajak berganda, apabila lebih dari satu orang dikenai pajak atas jenis penghasilan yang sama Pengenaan pajak berganda ini dapat menimbulkan penghindaran pajak. Maka guna meminimalisir adanya pajak berganda ini, dalam peraturan perpajakan terdapat pengecualian jenis objek pajak penghasilan yang diatur secara tegas guna meminimalisir adanya pajak berganda.Kata Kunci: Pajak Penghasilan; Dividen; Pajak Berganda.
Kewenangan Pemungutan Pajak Rokok Dalam Kaitannya Dengan Jaminan Kesehatan Nasional
Authors: Novendra Kristophorus Gerin
Published: May 2022

AbstractCigarette Tax is included in local taxes, to be precise it is a provincial taxes. But in Statute Number 28 of 2009 concerning Regional Taxes dan Regional Levies, Cigarette Tax are collected by the central government institute authorized to collect excise. In that Regulation its is also explained that provincial taxes is the full authority of provincial government so based on that ther is a conflict of norms on the authority to collect cigarette taxes. Cigarette tax as a provincial tax which is also a source of regional income based on the Minister of Finance Regulation Number 128/PMK.07/2018 concerning the Procedure for Withholding Cigarette Tax as a Contribution to Support for the Health Assurance Program must be deducted by 50% to finance the National Health Assurance program so that it affects on regional development.Keywords: Cigarette Tax; Authority; National Health Assurance.
AbstrakPajak rokok termasuk dalam pajak daerah, tepatnya pajak daerah provinsi. Dalam Undang-Undang Nomor 28 Tahun 2009 tentang Pajak Daerah dan Retribusi Daerah, Pajak Rokok dipungut oleh instansi pemerintah pusat yang berwenang memungut cukai. Dalam Undang-undang tersebut dijelaskan juga bahwa pajak daerah merupakan kewenangan penuh pemerintah daerah sehingga terdapat konflik norma atas kewenangan pemungutan pajak rokok. Pajak rokok sebagai pajak daerah yang juga merupakan sumber pendapatan daerah berdasarkan Peraturan Menteri Keuangan Nomor 128/PMK.07/2018 tentang Tata Cara Pemotongan Pajak Rokok sebagai Kontribusi Dukungan Program Jaminan Kesehatan harus dipotong sebesar 50% untuk pembiayaan program Jaminan Kesehatan Nasional sehingga berdampak pada pembangunan daerah. Kata Kunci: Pajak Rokok; Kewenangan; Jaminan Kesehatan Nasional.
Keabsahan Pemungutan Pajak Hotel Atas Jaringan Perhotelan OYO Rooms
Authors: Muhammad Zata Mahardika
Published: May 2022

AbstractHotel tax is a big tax potential for the state, especially for the regions. Indonesia is a country with a very large potential for the hospitality industry, this is indicated by the high level of both local and foreign tourists, thus encouraging the rapid development of the hospitality industry. The hotel industry is one of the great potential for government revenue, through hotel taxes. Along with the entry of the industry 4.0, with its disruption, which is marked by the rapid development of technology in the world of industry and business in Indonesia, business actors, both the Indonesian people and the global community, have begun to take advantage of technological developments in running their business, including Hotel Business. OYO Rooms is an online-based hotel network company, by providing booking services for lodging facilities that can be done through an application that can be downloaded on the smartphone or through the internet site (website).Keywords: Tax Collection; Hotel Tax; E-Commerce; OYO Rooms.
AbstrakPajak Hotel merupakan potensi pajak yang besar bagi negara, khususnya bagi daerah. Indonesia merupakan negara dengan potensi industri perhotelan yang sangat besar, hal ini ditandai dengan tingginya tingkat wisatawan lokal maupun mancanegara, sehingga mendorong berkembang pesatnya industri perhotelan. Industri perhotelan ini menjadi salah satu potensi pendapatan pemerintah yang besar, melalui pajak hotel. Seiring dengan masuknya era industri 4.0, yang ditandai dengan berkembang pesatnya teknologi dalam dunia industri dan bisnis di Indonesia, maka para pelaku usaha baik masyarakat Indonesia maupun masyarakat global mulai memanfaatkan perkembangan teknologi dalam menjalankan usahanya, termasuk Usaha Hotel. OYO Rooms merupakan perusahaan jaringan perhotelan dengan berbasis online, dengan menyediakan layanan pemesanan fasilitas penginapan tersdapat dilakukan melalui aplikasi yang dapat diunduh di gawai atau melalui situs internet (website).Kata Kunci: Pemungutan Pajak; Pajak Hotel; E-Commerce; OYO Rooms.
Is the Measure to Phase Out Crude Palm Oil in RED II discriminatory based on the World Trade Organization Law?
Authors: Amandari Laras Thyrza , Dewi Yetty Komalasari
Published: May 2022

The European Union enacted the Renewable Energy Directive 2018/2001 (RED II) policy under the pursuit of environmental protection. The authors will analyze how RED II is discriminative toward Indonesian trade of CPO, primarily within the concept of indirect land use change (ILUC), which restricts trade toward crude palm oil (CPO) whereas other domestic like products are exempted from such reduction. After the promulgation of this policy, Indonesia requested WTO to examine whether RED II follows the international obligations set forward in WTO. The author will analyze non-discrimination under WTO Law, specifically based on the provisions of Article 2.1, 2.2, and 5.1 Technical Barriers to Trade (TBT) Agreement as well as Article III:4, XX(b), and XX(g) of General Agreement on Tariffs and Trade (GATT) 1994, alongside with relevant jurisprudence of WTO case laws. This research is conducted through juridical-normative method, which utilizes library materials and secondary data. The outcome of this study shows that RED II does violate obligations of non-discrimination based on GATT and TBT due to differential treatment of like products that inflicts less favorable treatment and unequal opportunities of competition for CPO.
Ovarian cancer recurrence: is the definition of platinum sensitivity modified by PARPi, bevacizumab or other intervening treatments? : a clinical perspective
Authors: Rose Peter G.
Published: May 2022

In view of the high risk of recurrent disease in stage III and IV ovarian cancer following primary first-line chemotherapy, a variety of maintenance and consolidation treatment strategies have been developed. These have included: radiation, intravenous or intraperitoneal chemotherapy, targeted therapies, and immunotherapy. Popular at this time is the use of Poly-adenosine ribose polymerase (PARP) inhibitors and bevacizumab as maintenance therapy. What effect these maintenance or consolidation therapies have on subsequent response to therapy, specifically platinum-based chemotherapy, is only beginning to be studied. In this manuscript, we review the impact of PARP inhibitors and bevacizumab as well as radiation and maintenance chemotherapy on subsequent response to treatment. Prior use of bevacizumab does not appear to adversely affect subsequent response to platinum-based chemotherapy or platinum-based chemotherapy with bevacizumab. Prior therapy with PARP inhibitors induces platinum resistance to subsequent platinum-based therapy and negates classic predictors of response such as platinum-free interval and breast cancer susceptibility gene (BRCA) mutational status.
Моделирование внешнего силового воздействия на оболочковую форму для заливки стали
Authors: Евстигнеев Алексей Иванович , Evstigneev Aleksei Ivanovich , Дмитриев Эдуард Анатольевич , Dmitriev Eduard Anatol'evich , Чернышова Дарья Витальевна , Chernyshova Dar'ya Vital'evna , Одиноков Валерий Иванович , Odinokov Valerii Ivanovich , Евстигнеева Анна Алексеевна , Evstigneeva Anna Alekseevna , Иванкова Евгения Павловна , Ivankova Evgeniya Pavlovna
Published: May 2022

Сформулирована и решена задача по определению силового влияния опорного наполнителя на стойкость оболочковой формы (ОФ) при кристаллизации в ней жидкого металла (стали). В качестве ведущей физической величины, влияющей на трещиностойкость ОФ, принято растягивающее нормальное напряжение, возникающее в наружных слоях формы в первые временные моменты при заливке в нее
жидкого металла.
Силовым фактором, влияющим на напряженно-деформированное состояние (НДС)
ОФ, является трение между ОФ и опорным наполнителем (ОН), появляющееся при
упругом расширении наружного слоя в ОФ в результате температурного воздействия от кристаллизующегося жидкого металла. Формулируется задача математического программирования (функция minmax) по определению коэффициента трения
между ОФ и ОН для получения наименьшего значения нормального растягивающего напряжения в ОФ по рассматриваемой области при наличии системы ограничений.
Рассматривается осесимметричное тело вращения, имеющее четыре области: жидкий металл, твердый металл, оболочковая форма, опорный наполнитель, который
считается твердым телом, создающим трение на контакте соприкосновения с наружным слоем ОФ. Для решения задачи используются уравнения линейной теории
упругости, уравнение теплопроводности и апробированный численный метод, согласно которому исследуемая область разбивается системой ортогональных поверхностей на элементы. Для каждого элемента записывается сформулированная система уравнений в разностном виде. Разработан алгоритм решения задачи и приведены результаты решения, построены эпюры напряжений в ОФ по найденному значению коэффициента трения. Дан анализ полученных результатов.
maths e.g. as a learning resource
Authors: Greenhow Martin
Published: May 2022

This update describes the use of the “maths e.g.” question database in enhancing any sort of learning material by easily including specific ‘Try one yourself’ links to any of the over 5000 individual (randomised) questions or allowing student selection from the numerous topics/sub-topics that span the school/university interface and selected service mathematics content. A new question type is also presented to facilitate the (partial) testing of more theoretical material.
PENGARUH KUALITAS LAYANAN TERHADAP LOYALITAS DENGAN VARIABEL KEPUASAN SEBAGAI VARIABEL MEDIASI PADA WISATA PETIK APEL KELOMPOK TANI MAKMUR ABADI (KTMA)
Authors: Putri Ika Widya , Suprapti Isdiana
Published: May 2022

Penelitian ini dilatarbelakangi oleh Wisata Petik Apel KTMA yang mengalami penurunan jumlah wisatawan dan semakin banyaknya wisata lain di Kota Batu. Tujuan penelitian ini yaitu mengetahui (1) kualitas layanan, kepuasan dan loyalitas, (2) pengaruh langsung kualitas layanan terhadap loyalitas, (3) pengaruh kualitas layanan terhadap kepuasan, (4)pengaruh kepuasan terhadap loyalitas, (5) pengaruh kualitas layanan secara tidak langsung terhadap loyalitas dengan kepuasan sebagai variabel mediasi di wisata petik Apel KTMA. Sampel sebanyak 30 responden diperoleh menggunakan incidental sampling. Metode analisis data menggunakan analisis deskriptif dan analisis path. Hasil penelitian menunjukkan (1) kualitas layanan, kepuasan dan loyalitas wisatawan di wisata petik Apel KTMA tergolong baik, (2) loyalitas dari wisatawan secara langsung dipengaruhi oleh kualitas layanan, (3) kualitas layanan mempengaruhi kepuasan dari wisatawan, (4) kepuasan mempengaruhi loyalitas dari wisatawan, (5) kualitas layanan secara tidak langsung mempengaruhi loyalitas dengan variabel kepuasan sebagai variabel mediasi. Saran bagi wisata petik apel KTMA agar dapat mempertahankan bahkan meningkatkan kualitas layanan agar menciptakan kepuasan dan loyalitas wisatawan.