bluuebunny/crossref_metadata_2025 huggingface dataset:
Gute Begleitung wissenschaftlicher Arbeiten als Ansatz zur Prävention akademischen Fehlverhaltens / Good mentoring as an approach to preventing academic misconduct / Un bon encadrement de travaux de recherche en vue de prévenir les pratiques universitaires incorrectes
Authors: Johannes Dörte , Moritz Marie-Theres , Oestreicher Wencke
Published: January 2014

Das Thema akademische Integrität hat in den vergangenen Jahren durch die Plagiatsaffären von Personen des öffentlichen Lebens eine hohe gesellschaftliche Aufmerksamkeit erlangt. Wurden die damit einhergehenden wissenschaftsethischen Fragestellungen durch den Fokus auf akademisches Fehlverhalten bislang jedoch vornehmlich unter negativen Vorzeichen diskutiert, ist das Thema aus Sicht des Gutenberg Lehrkolleg (GLK) eng mit den Werten und Regeln guter wissenschaftlicher Praxis verbunden. Eine auf die Bedürfnisse der Studierenden abgestimmte Begleitung wissenschaftlicher Arbeiten durch das Lehrpersonal wird als zentraler Ansatz zur Prävention von Plagiaten auf Studierendenseite betrachtet. Vor diesem Hintergrund äußert sich Dörte Andres, Sprecherin des GLK-Leitungsgremiums und Universitätsprofessorin für Dolmetschwissenschaft am Fachbereich Translations-, Sprach- und Kulturwissenschaft der Johannes Gutenberg Universität Mainz (JGU), u. a. zu den Fragen, auf welche Weise bei Studierenden ein Bewusstsein für akademisches Fehlverhalten geschaffen werden kann und welchen Einfluss eine bedarfsgerechte Begleitung wissenschaftlicher Arbeiten hierauf hat bzw. haben kann. Abschließend werden Maßnahmen des GLK, welche darauf zielen, akademischem Fehlverhalten entgegenzuwirken und gute wissenschaftliche Praxis zu fördern, vorgestellt.
The evaluation of the hypoglycemic effect of soft drink leaf extract of Phyllanthus amarus (Euphorbiaceae) in rats
Authors: Adedapo Adeolu Alex , Ofuegbe Sunday Oluwaseun
Published: January 2014

Background:
Phyllanthus amarus has been used in traditional medicine in Nigeria to treat some disease conditions. This study evaluated the soft drink extract (SDE) of the plant for antidiabetic activities in rats.

Methods: Standard phytochemical methods were used to test for the presence of phytoactive compounds in the plant. Acute toxicity was carried out in mice to determine safe doses for this plant extract. The antidiabetic activities of the SDE of the plant were assessed using some standard tests as well as histological changes in liver, kidney and pancreas. Diabetes mellitus was induced in rats using alloxan, whereas glibenclamide at 0.2 mg/kg was the reference drug used in this study.

Results: The SDE at 200 and 400 mg/kg body weight caused a significant reduction of fasting blood glucose, a significant change in the oral glucose tolerance test, a marked effect in the hypoglycemic activity test, and a pronounced reduction in the glucose, cholesterol and triglyceride levels of diabetic rats. Histopathologically, the liver of the diabetic nontreated and glibenclamide-treated groups showed widespread vacuolar change in the hepatocytes, but there was no visible lesion seen in the kidney and pancreas of extract-treated and glibenclamide-treated groups. No lesion was also seen in the liver of the SDE-treated group.

Conclusions: The results from this study may have validated the traditional basis for the use of P. amarus as antidiabetic agent with the pharmacological activities attributed to the presence of flavonoids and other phenolics contained in this plant. At the doses used, SDE also appeared safer than glibenclamide even though the latter is more potent.
A New Fractional Model of Nonlinear Shock Wave Equation Arising in Flow of Gases
Authors: Singh Jagdev , Kumar Devendra , Kumar Sunil
Published: January 2014

In this paper, we present a numerical algorithm
based on new homotopy perturbation transform method
(HPTM) to solve a time-fractional nonlinear shock wave
equation which describes the flow of gases. The fractional
derivative is considered in the Caputo sense. The HPTM is
combined form of Laplace transform, homotopy perturbation
method and He’s polynomials. The nonlinear terms
can be easily handled by the use of He’s polynomials. The
technique finds the solution without any discretization or
restrictive assumptions and avoids the round-off errors.
The obtained results are in good agreement with the existing
ones in open literature and it is shown that the technique
introduced here is robust, efficient, easy to implement
and computationally very attractive.
Parametric Analysis of Entropy Generation in Off-centered Stagnation Flow Towards a Rotating Disc
Authors: Rashidi M.M. , Shamekhi L. , Kumar Sunil
Published: January 2014

The similarity solution for the steady stagnation
flow towards an off-centered rotating disc is gives a systemof
non-linear partial differential equations. These nonlinear
differential equations are numerically solved by applyingwell
known Keller-Box Method. After finding the velocity
distributions, the important designing subject, entropy
generation of this system has been analyzed. Graphical
results are presented to investigate effects of the rotation
ratio α, off-centering, Reynolds number and axial
height on the radial and azimuthal velocities and entropy
generation. In order to show the effectiveness of the Keller-
Box method, the obtained results are compared with available
solutions obtained using DTM. The obtained results
demonstrate the reliability of the algorithm and the Keller-
Box method is an attractive method in solving the systems
of nonlinear partial differential equations, and also the entropy
generation is an important parameter depends on
design andwork conditions that should be in the attention
of designers of these rotating systems.
Symmetry reduction in uranyl compounds with [(UO2)2(TO4)3]2- (T = Se, S, Mo) layers: crystal structures of the new guanidinium uranyl selenate and methylammonium uranyl sulfate
Authors: Gurzhiy Vladislav V. , Tyshchenko Darya V. , Krivovichev Sergey V. , Tananaev Ivan G.
Published: January 2014

Single crystals of the new guanidinium uranyl selenate, [CH6N3]2[(UO2)2(SeO4)3] (1), and methylammonium uranyl sulfate, [CH3NH3]2[(UO2)2(SO4)3] (2) have been prepared by isothermal evaporation from aqueous solutions under room-temperature conditions. The crystal structure of 1 has been solved by direct methods [monoclinic, P2, a = 9.9448(15), b = 9.727(2), c = 10.1508(15) Å, β = 90.213(12)°, V = 981.9(3) Å3, Z = 2] and refined to R1 = 0.0696 (wR2 = 0.1611) for 2511 reflections with |F0| ≥ 4σF using least square techniques. The crystal structure of 2 has been solved by direct methods [triclinic, P1, a = 8.4784(6), b = 9.7873(8), c = 9.8121(7) Å, α = 90.170(2), β = 95.744(2), γ = 90.136(2)°, V = 810.12(10) Å3, Z = 1] and refined to R1 = 0.0146 (wR2 = 0.0336) for 5378 reflections with |F0| ≥ 4σF using least square techniques. The structures of 1 and 2 are based upon the [(UO2)2(TO4)3]2- (T = Se, S) twodimensional uranyl layers formed by linkage of U pentagonal bipyramids and TO4 tetrahedra via common O atoms. The layers consist of two types of 4-membered rings; this topology has previously been observed in the structures of several actinyl compounds that crystallize in tetragonal or orthorhombic space groups. Violation of the higher symmetry is caused by tiltings of the TO4 tetrahedra, associated with displacement of bridging oxygen atoms from their ideal position induced by the formation of moderate hydrogen bonds with the organic cations.
Rebuilding Japantown
Authors: Oda Meredith
Published: January 2014

This article follows the transpacific process of race-making and urban redevelopment in the Japanese Cultural and Trade Center in San Francisco. Japanese Americans carved out spaces for themselves in the Center’s development by mediating between city representatives and Japanese interests and culture. Their role built on their professional skills as well as contemporary racial thinking about Japanese Americans and U.S. expansionism in the Pacific. As the United States sought out connections with a nation understood as particularly alien, Japanese Americans rearticulated contemporary perceptions of their foreignness toward their inclusion. This story helps us better understand how Japanese Americans moved from “alien citizens” through World War II to “success stories” just decades later, as well as some of the connections of the postwar Pacific world.
RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization
Authors: Chu Gina Chia-Yi , Zhau Haiyen E , Wang Ruoxiang , Rogatko André , Feng Xu , Zayzafoon Majd , Liu Youhua , Farach-Carson Mary C , You Sungyong , Kim Jayoung , Freeman Michael R , Chung Leland W K
Published: January 2014

Prostate cancer (PCa) metastasis to bone is lethal and there is no adequate animal model for studying the mechanisms underlying the metastatic process. Here, we report that receptor activator of NF-κB ligand (RANKL) expressed by PCa cells consistently induced colonization or metastasis to bone in animal models. RANK-mediated signaling established a premetastatic niche through a feed-forward loop, involving the induction of RANKL and c-Met, but repression of androgen receptor (AR) expression and AR signaling pathways. Site-directed mutagenesis and transcription factor (TF) deletion/interference assays identified common TF complexes, c-Myc/Max, and AP4 as critical regulatory nodes. RANKL–RANK signaling activated a number of master regulator TFs that control the epithelial-to-mesenchymal transition (Twist1, Slug, Zeb1, and Zeb2), stem cell properties (Sox2, Myc, Oct3/4, and Nanog), neuroendocrine differentiation (Sox9, HIF1α, and FoxA2), and osteomimicry (c-Myc/Max, Sox2, Sox9, HIF1α, and Runx2). Abrogating RANK or its downstream c-Myc/Max or c-Met signaling network minimized or abolished skeletal metastasis in mice. RANKL-expressing LNCaP cells recruited and induced neighboring non metastatic LNCaP cells to express RANKL, c-Met/activated c-Met, while downregulating AR expression. These initially non-metastatic cells, once retrieved from the tumors, acquired the potential to colonize and grow in bone. These findings identify a novel mechanism of tumor growth in bone that involves tumor cell reprogramming via RANK–RANKL signaling, as well as a form of signal amplification that mediates recruitment and stable transformation of non-metastatic bystander dormant cells.
Heterochromatin Position Effects on Circularized Sex Chromosomes Cause Filicidal Embryonic Lethality in Drosophila melanogaster
Authors: Ferree Patrick M , Gomez Karina , Rominger Peter , Howard Dagnie , Kornfeld Hannah , Barbash Daniel A
Published: January 2014

Some circularized X-Y chromosomes in Drosophila melanogaster are mitotically unstable and induce early embryonic lethality, but the genetic basis is unknown. Our experiments suggest that a large region of X-linked satellite DNA causes anaphase bridges and lethality when placed into a new heterochromatic environment within certain circularized X-Y chromosomes. These results reveal that repetitive sequences can be incompatible with one another in cis. The lethal phenotype also bears a remarkable resemblance to a case of interspecific hybrid lethality.
Effect of Ammonium Acetate on the Properties of Chemical Bath Deposited CdS Films
Authors: Al-Yafeai Abeer A. , Phok Sovannary , Al-Shaibani Sahar A. , Al-Baity Shifaa M. , Al-Hammadi Esmaeel M. , Hasoon Falah S.
Published: January 2014

This investigation is a comprehensive study of the effect of ammonium acetate on the electrical, optical, morphology and microstructure of CdS thin films grown by Chemical Bath Deposition method (CBD). Two sets of CdS thin films (A and B) were deposited on glass substrates at 60°C for 60 min. The films were deposited using chemical bath solution that consists of cadmium acetate, ammonium hydroxide, and thiourea. However, ammonium acetate was added into the chemical bath used to deposit set (B), where ammonium acetate was eliminated from bath solution used to deposit set (A). The films’ morphology was examined by Field Emission Scanning Electron Microscopy (FE-SEM), whereas, the chemical composition was investigated by Electron Probe Micro-Analyzer (EPMA). The X-Ray Diffraction (XRD) θ/2θ technique was applied to study the structure of the films. Atomic Force Microscopy (AFM) was used to measure the average surface roughness of the films, and Dektak Profilometer was used to determine the CdS films thickness. The optical and electrical properties for the films were determined using UV-Vis-NIR Spectrometer, and the Hall Effect technique, respectively. The highest carrier mobility was obtained for the films deposited in an ammonium acetate free bath. However, both films were polycrystalline with hexagonal structure exhibiting a tendency toward <002> texture, that increase with increasing the pH value of the chemical bath.
Ocorrência de dor lombar e fatores associados em crianças e adolescentes de uma escola privada do sul do Brasil
Authors: Lemos Adriana Torres de , Santos Fábio Rosa dos , Moreira Rodrigo Baptista , Machado Débora Teixeira , Braga Fernando Cesar Camargo , Gaya Adroaldo Cezar Araujo
Published: January 2014

Estudos têm demonstrado que indivíduos que apresentam dor lombar na infância e adolescência são acometidos também na vida adulta, reforçando a importância de que as causas sejam investigadas desde a idade escolar. Avaliou-se a ocorrência de dor lombar e fatores associados em 770 escolares de 7 a 17 anos de idade de uma escola privada de Porto Alegre, Rio Grande do Sul, Brasil. A dor lombar foi definida como dor ou desconforto na região lombar no último mês e avaliada por meio de questionário. A ocorrência de dor lombar foi de 31,6%, sendo mais prevalente no sexo feminino (41,9%) do que no masculino (21,4%). Os fatores associados à dor lombar foram sexo feminino, idade de 9 a 17 anos e os aspectos psicossociais hiperatividade (categorias limítrofe e anormal) e sintomas emocionais (categoria anormal). O mapeamento da ocorrência de dor lombar, bem como a investigação de seus fatores associados é de fundamental importância para a identificação de crianças e adolescentes em risco e para o desenvolvimento de programas eficazes de prevenção primária.
Breast cancer incidence and mortality in women under 50 years of age in Brazil
Authors: Santos Sabrina da Silva , Melo Leticia Rodrigues , Koifman Rosalina Jorge , Koifman Sergio
Published: January 2014

Many countries have reported an increase in breast cancer incidence in young women. The current study's objective was to explore breast cancer distribution in women less than 50 years of age in Brazil. A descriptive study on breast cancer incidence (selected cities) and mortality (Brazil and selected cities) in 2002-2004 was carried out, and the results were compared with those from other countries. The study also analyzed the trend in hospital morbidity and incidence rates for breast cancer. Porto Alegre (Rio Grande do Sul State) showed the highest incidence rates (17.9 and 165.5/100,000 in the 15-39 and 40-49-year age strata, respectively). Regarding mortality, Belo Horizonte (Minas Gerais State) showed the highest rate in the 15-39-year group and Porto Alegre in the 40-49-year group (2.8 and 25.5/100,000). Hospital admissions and incidence rates for breast cancer suggest a change in epidemiological distribution. The results reveal an epidemiological pattern of breast cancer in young Brazilian women with regional distribution characteristics.
Clinical and demographic differences between voluntary and involuntary psychiatric admissions in a university hospital in Brazil
Authors: Chang Tais Michele Minatogawa , Ferreira Luiz Kobuti , Ferreira Montezuma Pimenta , Hirata Edson Shiguemi
Published: January 2014

To assess the frequency of involuntary psychiatric hospitalizations from 2001 to 2008 and to determine associated clinical and socio-demographic characteristics, a retrospective cohort study was conducted. Adult admission data were collected from a university hospital in Brazil. Hospitalizations were classified as voluntary (VH) or involuntary (IH). Groups were compared using chi-square test for categorical variables and Mann-Whitney test for continuous non-parametric variables. The relative risk of certain events was estimated by the odds ratio statistic. Of 2,289 admissions, 13.3% were IH. The proportion of IH increased from 2.5% to 21.2% during the eight year period. IH were more frequently associated with female gender, unmarried status, unemployment, and more than 9 years of schooling. Psychotic symptoms were more common among IH. There were no differences in age, duration of hospitalization, or rate of attendance at first appointment after hospital discharge. Understanding of the characteristics associated with IH is necessary to improve the treatment of psychiatric disorders.
Factors associated with time free of oral candidiasis in children living with HIV/AIDS, São Paulo, Brazil
Authors: Konstantyner Thais Claudia Roma de Oliveira , Silva Aline Medeiros da , Tanaka Luana Fiengo , Marques Heloísa Helena de Sousa , Latorre Maria do Rosário Dias de Oliveira
Published: January 2014

In clinical practice, recurrence of thrush is common in children living with HIV/AIDS. The aim of this study was to determine the factors associated with time spent free of oral candidiasis using survival analysis for recurrent events. A retrospective cohort study was carried out with 287 children treated between 1985 and 2009 at a reference center in the city of São Paulo, Brazil. The Prentice, Williams and Peterson model for recurrent events was used for the investigation of factors associated with the time free of oral candidiasis. The following factors were associated with the time patients were free of oral candidiasis: moderate immunodepression (HR = 2.5; p = 0.005), severe immunodepression (HR = 3.5; p < 0.001), anemia (HR = 3.3; p < 0.001), malnutrition (HR = 2.6; p = 0.004), hospitalization (HR = 2.2; p < 0.001), monotherapy (HR = 0.5; p = 0.006), dual therapy (HR = 0.3; p < 0.001) and triple therapy/highly active antiretroviral therapy (HR = 0.1; p < 0.001). The method analyzed in the present study proved useful for the investigation of recurrent events in patients living with HIV/AIDS.
Violência institucional, autoridade médica e poder nas maternidades sob a ótica dos profissionais de saúde
Authors: Aguiar Janaina Marques de , d'Oliveira Ana Flávia Pires Lucas , Schraiber Lilia Blima
Published: January 2014

O presente artigo discute a violência institucional em maternidades sob a ótica de profissionais de saúde, com base nos dados de uma pesquisa sobre o tema na cidade de São Paulo, Brasil. Para tanto, foram entrevistados 18 profissionais de saúde atuantes nas redes pública e privada, dentre médicos obstetras, enfermeiras e técnicas em enfermagem. Foi utilizado um roteiro semiestruturado com questões sobre a experiência profissional e o conceito de violência. A análise revelou o reconhecimento desses profissionais de práticas discriminatórias e desrespeitosas no cotidiano da assistência a mulheres gestantes, parturientes e puérperas. São exemplos citados dessas práticas o uso de jargões pejorativos como forma de humor, ameaças, reprimendas e negligência no manejo da dor. Essas práticas não são geralmente percebidas pelos profissionais como violentas, mas sim como um exercício de autoridade em um contexto considerado "difícil". Tal contexto revela a banalização da violência institucional que travestida de boa prática, porque seria para o bem da paciente, acaba invisibilizada no cotidiano da assistência.
Análise de implantação da Rede Amamenta Brasil: desafios e perspectivas da promoção do aleitamento materno na atenção básica
Authors: Venâncio Sônia Isoyama , Martins Maria Cezira Nogueira , Sanches Maria Teresa Cera , Almeida Honorina de , Rios Gabriela Sintra , Frias Paulo Germano de
Published: January 2014

Avaliou-se a implantação da Rede Amamenta Brasil, estratégia elaborada pelo Ministério da Saúde para o incentivo à amamentação na atenção básica. Realizou-se pesquisa avaliativa do tipo análise de implantação do componente 1, considerando-se três níveis de análise (federal, estadual e municipal) e adotando-se o estudo de casos múltiplos. Elaboraram-se o modelo lógico e a matriz de indicadores da Rede Amamenta Brasil. Para apreensão do contexto organizacional, analisado por meio das categorias do Triângulo de Matus e do grau de implantação, foram utilizadas a análise documental, entrevistas e grupos focais. O grau de implantação foi obtido pela avaliação do cumprimento das atividades propostas nos três níveis; nos municípios, foram avaliados os critérios estabelecidos pelo Ministério da Saúde para certificação das unidades básicas. Identificaram-se diferentes contextos organizacionais e graus de implantação, variando, nos municípios, de 18% a 100%. Foi possível observar a influência do contexto sobre a implantação da estratégia, de modo que se evidenciou relação entre contextos mais favoráveis e graus de implantação mais avançados.
Experiência de pacientes com acupuntura no Sistema Único de Saúde em diferentes ambientes de cuidado e (des)medicalização social
Authors: Silva Emiliana Domingues Cunha da , Tesser Charles Dalcanale
Published: January 2014

Virtudes atribuídas às terapias complementares, como abordagem holística e centrada nos pacientes e estímulo à autocura, vêm sendo valorizadas e podem, em tese, atenuar a excessiva medicalização social hoje vigente. Dentre elas, a acupuntura destaca-se pela institucionalização e aceitação progressiva. O objetivo foi analisar a experiência de pacientes com acupuntura no Sistema Único de Saúde e como ela se insere no seu cuidado, à luz da medicalização social, esta pensada nos seus aspectos constitutivos das representações e modelos explicativos dos usuários. Foram entrevistados trinta pacientes selecionados das atenções primária e secundária de Florianópolis, Santa Catarina, Brasil. Observou-se relevantes resultados terapêuticos nas queixas principais, no sono, na disposição, no estado emocional e diminuição do uso de fármacos. Os modelos explicativos dos usuários e seu autocuidado foram pouco ou nada modificados pelo tratamento com acupuntura. Notou-se, todavia, um cuidado ampliado e menos iatrogênico, principalmente na atenção primária à saúde, em que houve pouca oferta de outras práticas da medicina chinesa associadas.
Aggressors and resilient youths in Medellin, Colombia: the need for a paradigm shift in order to overcome violence
Authors: Duque Luis F. , Montoya Nilton E. , Restrepo Alexandra
Published: January 2014

The objective of this study was to estimate the ratio of resilient youth and compare this to youth with aggressive behavior, and to youth who also exhibit sexually risky behavior and drug use. A cross-section study of a representative sample of people between aged between 12 and 60 who are residents of Medellin, Colombia, and its metropolitan area (N = 4,654) was employed using probabilistic multi-stage sampling. Youth between 14 and 26 years old were selected for the present analysis (n = 1,780). The proportion of resilient youth is 22.9%, of aggressors is 11.3%, and that of youth with other risky conduct is 65.8%. The high ratio of resilient youth calls for a reorientation of public policy toward prevention and control of violence, prioritizing the promotion of resilient behavior instead of continuing with tertiary prevention actions.
The relationship between physical aspects of quality of life and extreme levels of regular physical activity in adults
Authors: Maciel Erika da Silva , Vilarta Roberto , Modeneze Denis Marcelo , Sonati Jaqueline Girnos , Vasconcelos Julia Santos , Vilela Junior Guanis Barros , Oetterer Marília
Published: January 2014

This study aimed to check for any significant differences in perceived quality of life, specifically aspects of a physical nature, among volunteers who are more physically active and those less physically active in a university community. The sample consisted of 1,966 volunteers in a university community in Brazil. To assess physical activity levels, volunteers responded to the International Physical Activity Questionnaire (IPAQ), and to analyse the perception of quality of life they responded to WHOQOL-bref, which is classified into three groups according to level of physical activity, taking into account the metabolic equivalent index (MET) over a full week. For comparison, consideration was given to the first and third tertiles, respectively, namely groups of more and less active students. The results indicated that individuals who engaged in more physical activity had a more positive perception of quality of life compared to those who were less active in physical aspects related to the ability to work, energy for day-to-day activities and locomotion.
Borderline tuberculoid leprosy and type 1 leprosy reaction in a hepatitis C patient during treatment with interferon and ribavirin
Authors: Santos Mônica , Franco Emily dos Santos , Ferreira Paulo Luis da Costa , Braga Wornei Silva Miranda
Published: January 2014

Hepatitis C is an inflammatory disease of the liver caused by a single-stranded RNA virus belonging to the Hepacivirus genus in the Flaviviridae family, called the hepatitis C virus. After initial infection, 70% to 85% of the patients develop chronic hepatitis C with hepatic fibrosis. In addition to specific liver changes, various extrahepatic manifestations have been associated with the hepatitis C virus infection or with medications used to treat the condition. We report the case of a patient with chronic hepatitis C who presented with the signs and symptoms of borderline tuberculoid leprosy and type 1 reaction four months after the start of treatment with a pegylated interferon/ribavirin combination.
Pustular psoriasis of pregnancy (Impetigo herpetiformis) - case report
Authors: Kondo Rogerio Nabor , Araújo Fernanda Mendes , Pereira Allamanda Moura , Lopes Vivian Cristina Holanda , Martins Ligia Márcia Mario
Published: January 2014

Impetigo herpetiformis is a rare dermatosis of pregnancy with typical onset during the last trimester of pregnancy and rapid resolution in the postpartum period. Clinically and histologically, it is consistent with pustular psoriasis. This similarity has led some authors to name the disease "the pustular psoriasis of pregnancy". We report the case of a patient who developed impetigo herpetiformis in two sucessive pregnancies.
Congenital agminated melanocytic nevus - case report
Authors: Rocha Camila Roos Mariano da , Grazziotin Thaís Corsetti , Rey Maria Carolina Widholzer , Luzzatto Laura , Bonamigo Renan Rangel
Published: January 2014

Agminated nevus is a cluster group of melanocytic nevi confined to a localized area of the body. There are many pigmented lesions described in the literature as agminated, such as blue nevi, multiple lentigines and Spitz nevi, but only a few cases of congenital agminated melanocytic nevi have been described. We report a case of a male child who presented with congenital agminated nevi, emphasizing the importance of physical examination, dermoscopy, histopathological evaluation, differential diagnosis and follow up to rule out the possibility of dysplastic or malignant changes.
Carcinomatous degeneration of pilonidal cyst with sacrum destruction and invasion of the rectum
Authors: Nunes Luiz Fernando , Castro Neto Antonio Kneipp Pitta de , Vasconcelos Roberto André Torres , Cajaraville Flávio , Castilho Juliana , Rezende José Francisco Netto , Noguera Washington Silva
Published: January 2014

Malignant degeneration of pilonidal cysts is rare. The most common histologic type is the squamous cell carcinoma, triggered by the chronic inflammatory process. The growth of the lesion is typically slow. The diagnosis must be early and the appropriate treatment is ample surgical resection, including the presacral fascia. In some cases, as the present one, the diagnosis is made at a stage when the disease has progressed and invaded adjacent structures. In these cases the surgery involves multiple organ resection. We report the case of a patient with carcinomatous degeneration of pilonidal cyst, with bulky disease that extended up to the wall of the rectum. The treatment was extended resection, sacrectomy and abominoperineal resection of the rectosigmoid with permanent colostomy.
Diffuse systemic sclerosis with bullous lesions without systemic manifestations
Authors: Macedo Paula Renaux Wanderley Caratta , Mota Amanda Nascimento Cavalleiro de Macedo , Gripp Alexandre Carlos , Alves Maria de Fatima Guimarães Scotelaro , Klumb Evandro Mendes
Published: January 2014

Here, we describe an atypical case of systemic sclerosis in its diffuse cutaneous form with acute and rapid progression of the cutaneous condition, without any systemic manifestations and the infrequent formation of bullae, showing the importance of diagnosis and early treatment in such cases. This case also shows that special measures should be taken for bullous cutaneous lesions and ulcerations resulting from serious sclerosis, which are entry points and increase morbidity and risk of death. Other prognostic factors include age, ESR and renal and pulmonary involvement. Capillaroscopies can be useful predictors of greater severity of systemic scleroderma, revealing a greater link with systemic, rather than cutaneous, involvement.
Sporadic Kindler Syndrome with a novel mutation
Authors: Almeida Jr Hiram Larangeira de , Heckler Gláucia Thomas , Fong Kenneth , Lai-Cheong Joey , McGrath John
Published: January 2014

We report the case of a 28-year-old woman with Kindler syndrome, a rare form of epidermolysis bullosa. Clinically, since childhood, she had widespread pigmentary changes in her skin as well as photosensitivity and fragility of the skin and mucous membranes. The mucosal involvement led to an erosive stomatitis as well as esophageal, anal and vaginal stenoses, requiring surgical intervention. The diagnosis of Kindler syndrome was confirmed by DNA sequencing with compound heterozygosity for a nonsense/frameshift combination of mutations (p.Arg110X; p.Ala289GlyfsX7) in the FERMT1 gene.
Biological agents: investigation into leprosy and other infectious diseases before indication
Authors: Antônio João Roberto , Soubhia Rosa Maria Cordeiro , Paschoal Vania Del Arco , Amarante Carolina Forte , Travolo Ana Regina Franchi
Published: January 2014

Biological agents are widely used for various immune-mediated diseases, with remarkable effectiveness in the treatment of rheumatoid arthritis (RA), psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. However, attention needs to be drawn to the adverse effects of these therapies and the risk of reactivating underlying granulomatous infectious diseases such as tuberculosis, leprosy, syphilis, leishmaniasis, among others. The objective of this paper is to describe a case of leprosy in a patient with RA using anti-TNF alfa, demonstrating the need for systematic investigation of skin lesions suggestive of leprosy in patients who require rheumatoid arthritis therapeutic treatment, especially in endemic regions like Brazil.
Cutaneous protothecosis - case report
Authors: Silva Pâmela Craveiro Gomes da , Silva Sabrina Beirão da Costa e , Lima Ricardo Barbosa , D'Acri Antonio Macedo , Lupi Omar , Martins Carlos José
Published: January 2014

Cutaneous protothecosis is a rare infection caused by achlorophyllic algae of the genus Prototheca. The lesions usually occur on exposed areas, related with trauma, in immunocompromised patients. The most common clinical presentation is a vesicobullous and ulcerative lesion with pustules and scabs, simulating bacterial, fungal or herpetic infections or eczema. The diagnosis is determined by agent identification through histopathology, culture and the carbohydrates assimilation test. The finding of morula-like spherules is characteristic of Prototheca sp. Its rarity and non-specific clinical aspect may difficult the disease diagnosis. We report a case of a diabetic patient, in chronic use of systemic corticosteroids, that developed a skin lesion after trauma to the right leg.
Psoriatic scarring alopecia
Authors: Almeida Maiana Carneiro , Romiti Ricardo , Doche Isabella , Valente Neusa Yuriko Sakai , Donati Aline
Published: January 2014

Psoriasis is a relatively frequent inflammatory dermatosis. Scarring alopecia due to scalp psoriasis was first reported in 1972, but few reports have been written since then, showing that this is a very rare complication of a common disorder. We report a young Brazilian woman with longstanding scalp psoriasis, which progressed to scaring alopecia.
Phacomatosis pigmentovascularis type IIa - case report
Authors: Segatto Majoriê Mergen , Schmitt Eloísa Unfer , Hagemann Laura Netto , Silva Roberta Castilhos da , Cattani Cristiane Almeida Soares
Published: January 2014

Phacomatosis Pigmentovascularis is a rare syndrome characterized by capillary malformation and pigmentary nevus. A case of a 2-year-old patient is reported, who presented extensive nevus flammeus and an aberrant Mongolian spot, without systemic disease, manifestations that allow us to classify this case as type IIa Phacomatosis Pigmentovascularis, according to Hasegawa's classification.
Optic neuritis due to immunobiologics: first Brazilian case report
Authors: Silva Luiz Gustavo Martins da , Sasso Letícia Soares , Nelli Carlos José , Bernardes Filho Fred , Abreu Marilda Aparecida Milanez Morgado de
Published: January 2014

The change in immunological response obtained by immunobiologics has brought a new paradigm to the treatment of immune-mediated disorders. As a result of their efficacy, there is a positive impact on the quality of life of patients. However, severe side effects, such as demyelination of cerebral or peripheral nerves, have been reported. After review of literature using PubMed and MEDLINE data from 2000 to 2012, we identified the cases correlating the biological uniterms and optic neuritis. This article reports the first Brazilian optic neuritis case associated with the use of immunobiologics. This publication is justified by the rarity of the disease and atypical therapeutical evolution.
Agminate lichen aureus
Authors: Tortelly Violeta Duarte , Silva Roberto Souto da , Mota Amanda Nascimento Cavalleiro de Macedo , Piñeiro-Maceira Juan
Published: January 2014

Lichen aureus is a rare variant of pigmented purpura, with a chronic and benign course. It is generally asymptomatic and often occurs in the lower limbs, presenting as erythematous brownish, coppery or golden macules and/or papules. The diagnosis is based on clinical and histopathological findings. The dermatoscopic pattern has been considered a useful tool in diagnosis presumption. We describe a case with a confluent morphological pattern, called agminate lichen aureus.
Primary cutaneous centrofollicular lymphoma with a good response to radiotherapy
Authors: Camargo Cláudia Medeiros dos Santos , Bomm Lislaine , Abraham Leonardo Spagnol , Daher Rafael , Scotelaro Maria de Fátima Guimarães , Abulafia Luna Azulay
Published: January 2014

Primary cutaneous lymphomas have different clinical behavior and prognosis than systemic lymphomas of similar histological subtype. About 30% of non-Hodgkin lymphomas involve extranodal tissues, the skin being the second most affected body organ after the gastrointestinal tract (approximately 18%). According to the EORTC (European Organization for Research and Treatment of Cancer) classification, the lymphoma centrofollicular is indolent, since the lesions increase in size slowly over the years and spread to extracutaneous sites is uncommon. Based on this, radiotherapy has been considered the treatment of choice by many studies. We present the case of a patient who had cutaneous centrofollicular scalp lymphoma for 1 year and showed good response to radiotherapy.
Cutaneous leiomyomatosis in a mother and daughter
Authors: Lencastre André , Cabete Joana , Gonçalves Rui , João Alexandre , Fidalgo Ana
Published: January 2014

A 34-year-old woman with no known medical history was evaluated for multiple painful brown nodules and papules on the anterior aspect of the trunk. She mentioned a history of similar cutaneous findings on her mother. Biopsies of three lesions revealed piloleiomyomata. Renal and adrenal ultrasound revealed an isolated simple cortical cyst, and pelvic and endovaginal ultrasound revealed two uterine myomata. The clinical diagnosis of hereditary leiomyomatosis and renal cell cancer was corroborated by the identification of a heterozygous variant on exon 5 of the fumarate hydratase gene (c.578C>T p.T193I). Identification of the tumor piloleiomyoma should alert the dermatologist to this rare genodermatosis, which is associated with an increased risk of renal cell tumors, demanding multidisciplinary follow-up, and personal and family counseling.
Extra ocular sebaceous adenocarcinoma in HIV-positive patient - case report
Authors: Menezes Carla Kellen da Silva , Gomes Nathália Matos , Jalkh Alex Panizza , Franco Emily dos Santos , Martins Thalita Gomes
Published: January 2014

Sebaceous adenocarcinoma is a rare adnexal tumor that can affect the skin and is divided into ocular, a more common form and extra ocular, of a rarer occurrence. We report the case of a patient diagnosed with Acquired Immune Deficiency Syndrome (AIDS) who developed an extra ocular, bulky and fast-growing sebaceous adenocarcinoma on the face. The literature has suggested that transplanted patients and HIV-positive patients have an excess risk for developing adnexal tumors, including sebaceous adenocarcinoma.
Tufted angioma in ear auricle: importance of the differential diagnosis
Authors: Pires Carla Andréa Avelar , Sousa Brena Andrade de , Amin Gabriela Athayde , Bittencourt Maraya de Jesus Semblano , Miranda Mario Fernando Ribeiro de , Carneiro Francisca Regina Oliveira
Published: January 2014

Tufted angioma is an acquired vascular proliferation with specific histological characteristics. The most common clinical features are erythematous macules. It occurs predominantly in children and young adults, especially in the chest and neck. We report the case of a male patient, 12 years old, with an increased right ear auricle associated with erythematous macules and increased local temperature, referred with a diagnosis of lepromatous leprosy; however, this diagnosis was questioned. Histopathology was consistent with tufted angioma.
Cowden Syndrome: report of a case and brief review of literature
Authors: Porto Ana Carolina Souza , Roider Elisabeth , Ruzicka Thomas
Published: January 2014

We present the case of a female patient with facial cutaneous lesions, a cobblestone-like pattern of the oral mucosa, and verruciform lesions on the hand since her youth. She reported a history of breast cancer, endometrial cancer, melanoma and multiple benign tumors and cysts. PTEN gene analysis was performed and confirmed Cowden Syndrome, a rare genodermatosis with an autosomal dominant pattern of inheritance, characterized by multiple hamartomas. The phosphatase and tensin homolog (PTEN) gene negatively regulates cell proliferation and cell cycle progression. Loss of PTEN function contributes to an increased risk of cancer. We emphasize the importance of early detection and accurate management of Cowden Syndrome.
Systemic sarcoidosis induced by etanercept: first Brazilian case report
Authors: Unterstell Natasha , Bressan Aline Lopes , Serpa Laura Araújo , Castro Pérola Peres da Fonseca e , Gripp Alexandre Carlos
Published: January 2014

The antagonists of tumor necrosis factor alpha (TNF-α) are increasingly being used in the treatment of inflammatory and autoimmune diseases. Several adverse effects of these drugs have been reported, including the paradoxical development of sarcoidosis, especially with the use of etanercept. We present the first Brazilian case report of systemic sarcoidosis induced by etanercept and a literature review.
Lichen planus pigmentosus inversus
Authors: Barros Hugo Rocha , Almeida José Roberto Paes de , Dinato Sandra Lopes Mattos e , Sementilli Angelo , Romiti Ney
Published: January 2014

Twenty-five year old male patient presenting with asymptomatic brown spots, on cervical, axillary, inguinal and popliteal regions, for the last nine months. Pathological examination showed hydropic degeneration of the basal layer, pigmentary incontinence and moderate inflammatory lymphocytic infiltrate in the dermis. Lichen planus pigmentosus inversus is a rare subtype of lichen planus characterized by hyperchromic, asymptomatic or mildly pruritic macules, measuring from millimeters to centimeters in diameter, with defined borders, affecting intertriginous areas, most commonly in the axillae and groin of Caucasian patients. It presents unique lichenoid histology. We report a case with typical clinical features, histology and evolution.
Entre o igualitarismo e a reforma dos direitos das mulheres: Bertha Lutz na Conferência Interamericana de Montevidéu, 1933
Authors: Marques Teresa Cristina de Novaes
Published: January 2014

A Conferência Interamericana, realizada no Uruguai em novembro de 1933, marca o início de uma longa e consistente cooperação de Bertha Lutz com a diplomacia brasileira. Essa conferência representou uma vitória temporária de parcela radical do feminismo norte-americano - o National Party of Women - ao qual Bertha se opunha, por convicção e fidelidade pessoal a outros grupos feministas. Este ensaio examina as razões para os meios diplomáticos aderirem a defesa dos direitos das mulheres. O debate travado em Montevidéu também ilumina a compreensão do pensamento político de Bertha Lutz e abre novas perspectivas historiográficas para as culturas políticas dos feminismos.
Condições de produção dos feminismos artísticos em Portugal
Authors: Fonseca Rui Pedro Paulino da
Published: January 2014

A primeira secção deste artigo incide num estudo representativo dos feminismos artísticos praticados em Portugal. Grande parte das referências de artistas, activistas ou grupos foi pesquisada e acedida on-line, num processo de trabalho que combinou a consulta e pedidos de depoimentos às/aos artistas sobre as suas obras e imagens. A segunda secção pretende mensurar as condições de produção de arte feminista. Tal foi possível sobretudo através do levantamento de dados on-line relativos à representatividade de artistas homens e mulheres em algumas das principais instâncias artísticas. Adicionalmente, foram articulados alguns testemunhos de agentes artísticos que documentassem alguns dos obstáculos presentes no sistema artístico português impostos às mulheres artistas, assim como à produção de arte feminista.
Sexualidades marginais nas bordas do texto: cinema, política e performatividade de gênero em El beso de la mujer araña
Authors: Alós Anselmo Peres
Published: January 2014

Este artigo pretende discutir algumas das ambivalentes relações entre cinema, política e performatividade de gênero no romance El beso de la mujer araña [O beijo da mulher-aranha], romance argentino escrito por Manuel Puig e publicado pela primeira vez em 1976. Embora esse romance não seja o primeiro a problematizar gênero e performatividade no contexto da literatura latino-americana, ele apresenta um enredo particularmente subversivo no que diz respeito à representação de rupturas no interior dos preceitos heteronormativos.
Variabilidade genética na busca de eficiência à produção de sementes e biomassa de capim Sudão
Authors: Silva José A. G. da , Arenhardt Emilio G. , Gewehr Ewerton
Published: January 2014

Objetivou-se, com o estudo, conhecer a variabilidade genética de caracteres ligados à inflorescência em populações de capim Sudão e a contribuição dessas variáveis na definição do caráter mais efetivo na seleção para a produtividade de sementes. Além disto, fornecer subsídios em indicar que a pressão de seleção sobre os componentes da panícula visando aos incrementos na produção de sementes, não compromete os caracteres de interesse forrageiro. Os experimentos foram realizados nos anos de 2009 e 2010, na seleção de plantas para os caracteres perfilhamento, produção de biomassa e dos que compõem a inflorescência da espécie; verificou-se que existe variabilidade genética entre as populações de capim Sudão, principalmente nos caracteres massa de panícula, número de grãos da panícula e massa de grãos da panícula, variáveis de maior contribuição sobre as diferenças morfológicas observadas na inflorescência. Correlações efetivas foram obtidas pela massa de panícula e número de grãos da panícula em incrementar a massa de grãos da panícula. A pressão de seleção sobre esses caracteres não traz prejuízos sobre a biomassa e o perfilhamento.
Waste gas treatment in bioreactors: environmental engineering aspects
Authors: Kennes Christian , Montes María , López M. Estefanía , Veiga María C.
Published: January 2014

This paper gives an overview of the most important bioreactor configurations used in waste gas treatment, i.e., conventional and trickling biofilters, the bioscrubber, suspended-growth bioreactors, as well as two-liquid phase systems (stirred tank bioreactor and biotrickling filter). The historical evolution, main characteristics, and recent developments are described in each case.
Bioaerosols in industrial environments: a review
Authors: Gilbert Yan , Duchaine Caroline
Published: January 2014

Air quality in workplaces is a main concern for industrial hygienists and occupational health specialists. Aerosolization of microorganisms or their by-products from contaminated material can significantly decrease the air quality and expose the workers’ health to potentially harmful effects. To identify the risks and elaborate safe exposure thresholds, the microbiology of air samples from industrial workplaces must be characterized, which means the airborne microorganisms must be identified and quantified. This review summarizes, for nonbiologist specialists, the principal sampling and analysis techniques for air sample characterization regarding microbiological contamination. A survey of the literature regarding levels of airborne bacteria, fungi, and viruses in agricultural industries, waste management plants, peat and wood processing facilities, and other industries is also provided. This review shows that very complex bioaerosol sources are present in industrial settings, and variable and hardly predictable biodiversity is expected in such environments.
Mathematical modeling and simulation of hexane degradation in fungal and bacterial biofilters: effective diffusivity and partition aspects
Authors: Arriaga Sonia , Revah Sergio
Published: January 2014

Mathematical modeling in the biofiltration of volatile organic compounds is a valuable tool for performance prediction and in scaling up. Majority of the published models include parameters obtained from fitting experimental data, thus masking their real influence as they are lumped generally. The present work aims to evaluate experimentally some of the most relevant parameters including kinetic constant, partition coefficient in the biofilm, biofilm thickness, superficial area, and effective diffusivity. For the fungal biofilm, all the parameters mentioned above were obtained experimentally; and for the bacterial biofilm, the biofilm thickness and some intrinsic parameters used to obtain the first-order kinetic constant were taken from the literature. These parameters were then incorporated in a mathematical model to describe the steady-state degradation of hexane in bacterial and fungal biofilters operating under continuous mode. Experimentally, the dimensionless partition coefficients (mG) indicated that hexane was 4 and 35 times more soluble in the bacterial (mG = 9·14) and fungal (mG = 0·88) biofilters, respectively, than in water (mG = 30·4). Comparison of model estimates with experimental concentration profiles of the pollutant along the height of the biofilters proves that the first-order limited by reaction model was appropriate to interpret the experimental results with a small error of ∼1%.