bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality by Design-based RP-HPLC Method for Estimation of Curcumin in
Rat Plasma and Fecal Microbiota Extract-based Solid Self-nano Emulsifying
Drug Delivery System
Authors: Corrie Leander , Gulati Monica , Kaur Jaskiran , Awasthi Ankit , Vishwas Sukriti , Ramanunny Arya Kadukkattil , Khursheed Rubiya , Dua Kamal , Chellappan Dinesh Kumar , Singh Sachin Kumar
Published: January 2023

Background:

Curcumin (CRM) is known to possess various therapeutic properties,
such as anti-inflammatory and antidiabetic properties, and is, therefore, considered to be an effective
therapeutic.

Objective:

A sensitive method for the estimation of CRM in plasma, as well as fecal matter-based
solid self-nano emulsifying drug delivery system (S-SNEDDS), has been reported for the first
time.

Methods:

A bioanalytical method was optimized using Box-Behnken Design having 13 runs and 3
responses. The optimized method was developed using methanol and water (70:30 v/v) with a flow
rate of 1 mL/min. Quercetin was used as an internal standard. A specificity test was also performed
for the developed CRM solid self-nano emulsifying drug delivery system.

Results:

The retention time of CRM was found to be 14.18 minutes. The developed method was
validated and found to be linear in the range of 50-250 ng/mL with an R2 of 0.999. Accuracy studies
indicated that CRM had a percentage recovery of less than 105% and more than 95%, respectively.
Precision studies were carried out for inter, intraday, and inter-analyst precision, and the
%RSD was found to be less than 2%. The limit of detection (LOD) and limit of quantification
(LOQ) were found to be 3.37 ng/mL and 10.23 ng/mL, respectively. Stability studies for shortterm,
long term and freeze-thaw cycles showed a %RSD of less than 2%, indicating the stability of
CRM in the plasma matrix. Moreover, the blank fecal microbiota extract slurry did not show any
peak at the retention time of CRM in a CRM-loaded solid nanoemulsifying drug delivery system
containing fecal microbiota extract indicating its specificity.

Conclusion:

Hence, the developed method can have clinical implications as it helps estimate CRM
in blood samples and also provides a simple and sensitive method for the estimation of plant-based
flavonoids along with fecal microbiota extract formulations.
Novel Approaches of Self Emulsifying Drug Delivery Systems and Recent
Patents: A Comprehensive Review
Authors: Nandal Rimmy , Tahlan Sumit , Deep Aakash
Published: January 2023

The main aim of the current work is to set up a revolutionary Self Nano-emulsifying
drug delivery system to improve the necessary bio-availability and to boost clinical efficacy when
administered orally. This study's main target is to develop a novel self-nano emulsifying drug delivery
system (SNEDDS) for orally administered, poorly water-soluble medicines. SNEDDS is designed
to intensify weakly water dissolvable or lipophilic drugs. SNEDDS is designed to intensify
weakly water dissolvable or lipophilic drugs. It contains a micro- or nano-emulsion of oil carrying
medicament that spontaneously agitates an aqueous medium. For enhancing the solubility of lipophilic
medicines, SNEDDS is the most significantly used in biopharmaceutics classification system
[BCS class] II and IV pharmaceuticals. The improved rate of dissolution and prevention of interfacial
tension are clearly demonstrated by SNEDDS. In aqueous mediums, such as gastrointestinal
fluid, SNEDDS produces a stable emulsion after dilution.
Novel Information Regarding the Treatment of Helicobacter pylori Infection:
A Systematic Review and Meta-analysis of Randomized Clinical Trials
Authors: Kiani Faezeh , Khademolhosseini Sara , Mohammadi Jasem , Tavasol Arian , Hajibeygi Ramtin , Fathi Mobina , Dousti Majid
Published: January 2023

Objective:

Helicobacter pylori infects at least 50% of the world’s human population. The
current study aimed to assess and compare the efficacy of triple versus quadruple therapy.

Methods:

Randomized clinical trials (RCTs) consisting of triple and quadruple therapy were identified
through electronic and manual searches in the national and international online databases (IsI, Magiran,
Embase, PubMed, and Scopus). The random-effects model was applied to pool analysis. Funnel
plots and the Egger test were used to examine publication bias.

Results:

After a detailed review of the selected articles, 80 RCTs were included in the meta-analysis;
it was based on using triple and quadruple therapy as the first and second-line treatment. The results
showed that quadruple therapy in the first-line treatment had a higher eradication rate than triple therapy.
Overall, the eradication rate with triple therapy was 74% (95% CI, 71%-77%) for intention-totreat
(ITT) analysis and 80% (95% CI, 77%-82%) for per-protocol (PP) analysis. Generally, the eradication
rate with quadruple therapy was 82% (95% CI, 78.0%-86.0%) for ITT analysis and 85% (95%
CI, 82.0%-89.0%) for PP analysis. The analysis also revealed that quadruple therapy was more effective
for 7 or 10 days.

Conclusion:

The current study results demonstrated that quadruple therapy has better effectiveness
than triple therapy as the first-line treatment; however, in the second-line treatment, the effectiveness
of quadruple and triple regimens is almost similar. The effectiveness of quadruple therapy in the Asian
population was found to be slightly higher than that of triple therapy, while this difference was considerably
higher in the European population.
Servicios ecosistémicos de las especies nativas e introducidas de bambú en la Huasteca Potosina, México: usos del bambú
Authors: Reyes-Agüero Juan Antonio , Cruz-Armendáriz Natalia María , Ruiz-Sanchez Eduardo
Published: January 2023

Antecedentes y Objetivos: En la Huasteca Potosina (HP) existen siete especies nativas de bambú, pero se desconoce la riqueza de especies introducidas. De ambos grupos se carece del registro de los servicios ecosistémicos (SE) que proporcionan. Por ello, los objetivos del estudio fueron registrar la presencia de las especies introducidas de bambú en la HP e identificar los SE de las especies nativas e introducidas. Métodos: Se efectuaron exploraciones botánicas para visitar todos los municipios del área de estudio; se realizaron 57 recolectas botánicas. Para el registro de los SE de las especies nativas e introducidas se hicieron observaciones en campo, se visitaron comunidades en donde se cultiva y utiliza el bambú y se realizaron 31 entrevistas a informantes clave. Resultados clave: Además de las siete especies nativas de bambú en la HP, existen 11 taxones (diez especies y una variedad) introducidos, todos estos de culmos leñosos. Ocho especies y la variedad son nativas de Asia, una lo es de Sudamérica y otra introducida del estado de Veracruz, México. Las especies introducidas con mayor distribución son Bambusa vulgaris, B. vulgaris var. vittata y B. oldhamii. El principal uso del bambú leñoso es para la construcción y la especie nativa más utilizada para ello es Guadua velutina. Las especies introducidas son producidas para ornato, cerco vivo y construcción. Conclusiones: En la HP hay 44 ha de plantaciones comerciales de bambú; junto con las especies nativas proporcionan tres SE y cinco usos. Los resultados de este trabajo son la base para futuras investigaciones sobre los servicios ecosistémicos del bambú en la HP. Es necesario continuar con el monitoreo de plantaciones comerciales, ya que van en aumento; además de evaluación de los efectos de diferentes prácticas de manejo en plantaciones y usos potenciales, sobre todo de especies nativas.
Bioetika, umjetnost i tjelesna kateksa u osoba s invaliditetom
Authors: Martinec Renata
Published: January 2023

U suvremenom se društvu samoprocjena i socijalna recepcija tjelesne manifestacije u osoba s invaliditetom nalazi u vrlo zahtjevnom i izazovnom području. Iz tog se razloga nastoji promovirati „estetika invaliditeta“ s namjerom naglašavanja potrebe prihvaćanja onih „tijela“ različitih od poželjne, socijalno uvjetovane, estetske reprezentacije. U tom bi se pokušaju i umjetnost trebala razmatrati kao zanimljiv medij, budući da kroz proigravanje s prihvatljivim elementima forme može promicati univerzalnost estetike i otkrivati ljepotu u njezinoj nesavršenosti i nedovršenosti. Jer upravo ono drugačije i neshvatljivo u povezanosti s prihvatljivom estetskom formom izražava jedinstvo suprotnosti i omogućuje doživljaj cjelokupne raznolikosti i raskoši ljudske tjelesnosti. U tom se smislu ne potiče samo socijalna senzibilizaciju prema tjelesnoj nesavršenosti, već i pozitivna tjelesna kateksa koja ima jednu od presudnih uloga u definiranju doživljaja sebe, kao i u formiranju vlastitih emocija, predodžbi i ponašanja. Na tom tragu, upravo bi interdisciplinarna suradnja trebala biti osnova za poticanje usvajanja novih paradigmi i estetskih kriterija prema kojima bi svaki pojedinac, usprkos „nepotpunoj ljepoti“, bio metafora posebnog, neponovljivog i jedinstvenog. U svojoj konačnici, takvo uvjerenje može pomoći u postizanju osjećaja samozadovoljstva i samoostvarenja, kao dijela temeljnih dostignuća vlastite egzistencije.
Social Structural Prospects for the AI Era
Authors: Kim Bun-Sun
Published: January 2023

In this paper, I will detail the phenomenal problems involved in the AI era. Issues such as information bubble, post-truth, and digital prison will point to the problems that arise in an environment based on AI technology. This article will also show that, after Covid-19, the AI-based environment has changed not only as a technology as a tool for humans, but also as a condition for survival. From this, we diagnose the problems of control, monitoring, and subjection brought about by the development of AI technology and the changes to the living environment caused by the Covid-19 outbreak. Synthesizing these problematic situations, I argue that the AI-based environment is not designed to cause social change as a result of natural changes or technological progress, but as a kind of discipline mechanism. I believe that it is necessary to consider how this will affect the changes and development of human society, and that it is necessary to predict this through social structural changes. Through this process, I will discuss this concept by analogically applying them to the problems of the AI era. I would like to ask a fundamental question about whether the AI era will be able to achieve real progress for humans and human society. Moreover, through this comprehensive investigation, this article draws the conclusion that AI as a discipline device will play a critical role in producing new power.
Informed Consent and Public Health
Authors: Tucak Ivana , Pelčić Gordana
Published: January 2023

Informed consent, which is primarily aimed at encouraging individual patients and subjects of scientific research to make autonomous decisions, and public health measures, such as compulsory vaccination against infectious diseases, the successfulness of which implies harmonized administration of vaccines to a broad population, seem to be irreconcilable opposites at first glance. This paper deals with investigating whether these opposites can reconcile or whether informed consent can be applied in the field of public health. The first part of the paper provides a short overview of the main features of informed consent and its relevance in treating individual patients. The second part of the paper tackles the issue of immunization. If not provided with consent of their patients or having a legal obligation, physicians are believed to interfere with the bodily integrity of other people when conducting vaccination and their act can be deemed as an assault and entail non-pecuniary damage compensation. Herd immunity as a “public good” can only be achieved if all people are equally subject to public health measures. At this point, the key question is if informed consent and appertaining freedom of decision-making represent a threat to the accomplishment of this public health goal. This question should truly be answered since vaccination may, though rarely, bring to medical complications, which may then lead to high treatment costs, loss of income and extremely rare, to death. The purpose of this paper is to demonstrate that disclosure of the risks and benefits of immunization within the framework of public health programmes could contribute to putting the fundamental bioethical postulates into practice: establishing and fostering mutual trust between physicians and their patients, which can, in the end, contribute to a higher immunization rate of a population.
A Decentralized Marketplace for Patient-Generated Health Data: Design Science Approach
Authors: Subramanian Hemang
Published: January 2023

Background

Wearable devices have limited ability to store and process such data. Currently, individual users or data aggregators are unable to monetize or contribute such data to wider analytics use cases. When combined with clinical health data, such data can improve the predictive power of data-driven analytics and can proffer many benefits to improve the quality of care. We propose and provide a marketplace mechanism to make these data available while benefiting data providers.

Objective

We aimed to propose the concept of a decentralized marketplace for patient-generated health data that can improve provenance, data accuracy, security, and privacy. Using a proof-of-concept prototype with an interplanetary file system (IPFS) and Ethereum smart contracts, we aimed to demonstrate decentralized marketplace functionality with the blockchain. We also aimed to illustrate and demonstrate the benefits of such a marketplace.

Methods

We used a design science research methodology to define and prototype our decentralized marketplace and used the Ethereum blockchain, solidity smart-contract programming language, the web3.js library, and node.js with the MetaMask application to prototype our system.

Results

We designed and implemented a prototype of a decentralized health care marketplace catering to health data. We used an IPFS to store data, provide an encryption scheme for the data, and provide smart contracts to communicate with users on the Ethereum blockchain. We met the design goals we set out to accomplish in this study.

Conclusions

A decentralized marketplace for trading patient-generated health data can be created using smart-contract technology and IPFS-based data storage. Such a marketplace can improve quality, availability, and provenance and satisfy data privacy, access, auditability, and security needs for such data when compared with centralized systems.
Social Media Data Mining of Antitobacco Campaign Messages: Machine Learning Analysis of Facebook Posts
Authors: Lin Shuo-Yu , Cheng Xiaolu , Zhang Jun , Yannam Jaya Sindhu , Barnes Andrew J , Koch J Randy , Hayes Rashelle , Gimm Gilbert , Zhao Xiaoquan , Purohit Hemant , Xue Hong
Published: January 2023

Background

Social media platforms provide a valuable source of public health information, as one-third of US adults seek specific health information online. Many antitobacco campaigns have recognized such trends among youth and have shifted their advertising time and effort toward digital platforms. Timely evidence is needed to inform the adaptation of antitobacco campaigns to changing social media platforms.

Objective

In this study, we conducted a content analysis of major antitobacco campaigns on Facebook using machine learning and natural language processing (NLP) methods, as well as a traditional approach, to investigate the factors that may influence effective antismoking information dissemination and user engagement.

Methods

We collected 3515 posts and 28,125 associated comments from 7 large national and local antitobacco campaigns on Facebook between 2018 and 2021, including the Real Cost, Truth, CDC Tobacco Free (formally known as Tips from Former Smokers, where “CDC” refers to the Centers for Disease Control and Prevention), the Tobacco Prevention Toolkit, Behind the Haze VA, the Campaign for Tobacco-Free Kids, and Smoke Free US campaigns. NLP methods were used for content analysis, including parsimonious rule–based models for sentiment analysis and topic modeling. Logistic regression models were fitted to examine the relationship of antismoking message-framing strategies and viewer responses and engagement.

Results

We found that large campaigns from government and nonprofit organizations had more user engagements compared to local and smaller campaigns. Facebook users were more likely to engage in negatively framed campaign posts. Negative posts tended to receive more negative comments (odds ratio [OR] 1.40, 95% CI 1.20-1.65). Positively framed posts generated more negative comments (OR 1.41, 95% CI 1.19-1.66) as well as positive comments (OR 1.29, 95% CI 1.13-1.48). Our content analysis and topic modeling uncovered that the most popular campaign posts tended to be informational (ie, providing new information), where the key phrases included talking about harmful chemicals (n=43, 43%) as well as the risk to pets (n=17, 17%).

Conclusions

Facebook users tend to engage more in antitobacco educational campaigns that are framed negatively. The most popular campaign posts are those providing new information, with key phrases and topics discussing harmful chemicals and risks of secondhand smoke for pets. Educational campaign designers can use such insights to increase the reach of antismoking campaigns and promote behavioral changes.
Preparation of SARS-CoV-2 Polymerase Nsp12 and Optimization of Expression Conditions
Authors: Liu Yifei
Published: January 2023

he core component of transcription and replication of SARS-CoV-2 is Nsp12, a non-structural protein that function as an RNA-dependent RNA polymerase. Nsp12 is a key drug target for the development of anti-coronavirus drugs. The purpose of this study was to explore and optimize the expression conditions of Nsp12 of SARS-CoV-2 with the aim of establishing expression conditions to obtain high-purity Nsp12 protein. This study compared the “ice-water bath cooling” and “shaking table cooling” methods and explored the differences in cooling rates and protein expression and properties using the two cooling methods. The shaking table cooling method resulted in reduced amounts of ArnA protein in the Nsp12 protein samples compared with levels from the ice-water bath cooling method. The shaking table method enabled purification of high-quality Nsp12 protein and ensured stable output of the protein. These methods will enable subsequent exploration of the SARS-CoV-2 replication mechanism, the development of specific drugs and drug screening for anti-SARS-CoV-2 pneumonitis.
Cost–effectiveness of imipenem/cilastatin/relebactam for hospital-acquired and ventilator-associated bacterial pneumonia
Authors: Naik Jaesh , Dillon Ryan , Massello Matthew , Ralph Lewis , Yang Zhuo
Published: January 2023

Aim:
This study evaluates the cost–effectiveness of imipenem/cilastatin/relebactam (IMI/REL) for treating hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP) in an ‘early adjustment prescribing scenario’.
Methods:
An economic model was constructed to compare two strategies: continuation of empiric piperacillin/tazobactam (PIP/TAZ) versus early adjustment to IMI/REL. A decision tree was used to depict the hospitalization period, and a Markov model used to capture long-term outcomes.
Results:
IMI/REL generated more quality-adjusted life years than PIP/TAZ, at an increased cost per patient. The incremental cost–effectiveness ratio of $17,529 per QALY is below the typical US willingness-to-pay threshold.
Conclusion:
IMI/REL may represent a cost-effective treatment for payers and a valuable option for clinicians, when considered alongside patient risk factors, local epidemiology, and susceptibility data.
GRP78 promotes the osteogenic and angiogenic response in periodontal ligament stem cells
Authors:   Department of Oral Biology, University of Illinois at Chicago, Chicago, Illinois 60612, USA, Merkel A , Chen Y , Villani C , George A
Published: January 2023

Periodontitis is a progressive disease that ultimately leads to bone and tooth loss. A major consequence of periodontal disease is the inability to regain lost bone in the periodontium. The importance was demonstrated of glucose-regulated protein-78 (GRP78) in the osteogenic differentiation of periodontal ligament stem cells and their potential use for regeneration of the periodontium. Previous studies have shown the relationship between GRP78 and dentine matrix protein-1 (DMP1). The importance of this receptor-ligand complex in supporting the process of osteogenesis and angiogenesis was confirmed in this study. To show the function of GRP78 in mineralised tissues, transgenic periodontal ligament stem cells (PDLSCs) were generated in which GRP78 was either overexpressed or silenced. Gene expression analysis of the cells cultured under osteogenic conditions showed an increase in key osteogenic genes with the overexpression of GRP78. RNA-Seq analysis was also performed to understand the transcriptome profile associated with genotype changes. Using the database for annotation, visualisation, and integration discovery (DAVID) for the functional enrichment analysis of differentially expressed genes, the upregulation of genes promoting osteogenesis and angiogenesis with GRP78 overexpression was demonstrated. Alizarin red staining and scanning electron microscopy analysis revealed matrix mineralisation with increased calcium deposition in GRP78 overexpressing cells. The in vivo osteogenic and angiogenic function of GRP78 was shown using a subcutaneous implantation rodent model. The results suggested that GRP78 in PDLSCs can regulate the expression of both osteogenesis and angiogenesis. Therefore, GRP78 could be considered as a therapeutic target for repair of diseased periodontium.
Study and Performance Characteristics of Gasoline Direct Injection Engine Using Alternative Fuels
Authors: A Suryaprakash , K Kumaravel , D Kulandaivel , K Ramesh
Published: January 2023

Abstract: Biogas is the one of the best alternative fuel for IC engines. However some improvements and different techniques are still needed. In this research biogas with petrol fuelled Gasoline Direct Injection (GDI) engine performance was to be studied. The current study shows that biogas with petrol using GDI engine, particularly beneficial to reach interesting conversion efficiencies. It allows a significant boost in energy conversion from biogas compared to existing system.
Optimization of Deep Neural Networks Using DAPP (DNN Acceleration Using Ping-Pong) Approach
Authors: Naik Mashkoor Ahmad , Singh Er. Jasdeep
Published: January 2023

Abstract: Deep Neural Networks (DNNs) are one of the leading classification algorithms. Deep Learning has achieved remarkable milestones such as Google-Net and Alpha-Go. They have shown promising results in pattern recognition for images and text, language translation, sound recognition, and many more. DNN has been widely accepted and also employed for pattern matching and image recognition. All these applications are possible as these networks emulate functioning of human brain and hence name “Neural” Network.However, to provide competent results, these millions of neurons in neural networks needs to be trained. For which billions of operations are to be carried out. Training of these many neurons and with these many operations is a time-consuming affair. Hence choice of network and its parameter play an important role both in providing accurate trained network and time taken for training. If the network is deep and has plethora of neurons, the time taken is considerably high as training works sequentially on batches of dataset using Sequential Back-propagation Algorithm.To accelerate the training there are many hardware solutions like use of GPU, FPGA and ASICs. However because of popularity of DNN there is increase in demand in mobile and IoT platform devices. These are resource constrained devices, where power and size of these device, restricts usage and implementation of deep NN (Neural Network).Simulation of DAPP is done on MNIST and CIFAR-10 datasets using System-C. Additionally, this technique has been adapted for multi-core architectures. The design shows a reduction in time by 38% for 3 layers of CNN and 92% for 10 layers of CNN, while maintaining the accuracy of networks. This generic methodology has been implemented for Vanilla RNN and LSTM networks. An improvement of 38% for Vanilla RNN and 40% for LSTM has been demonstrated by this methodology.
Obesidad y sobrepeso en Estados Unidos de Norteamérica en la última década
Authors: Restrepo Betancur Fernando
Published: January 2023

Introducción. La obesidad y el sobrepeso son una de las mayores problemáticas a la que se enfrenta la sociedad en la actualidad. Las cifras indican que la obesidad es hoy en día una de las enfermedades con un mayor índice de morbilidad, disminuyendo la esperanza de vida representando un alto riesgo de mortalidad. Objetivo. Consistió en describir y comparar el porcentaje de obesidad y sobrepeso entre los diferentes Estados de EE. UU. Metodología. Se empleó un análisis de frecuencia de carácter unidimensional expresado mediante porcentajes, asociado a las variables porcentaje de obesidad y sobrepeso. Adicionalmentese empleó el análisis multivariado de la varianza, a fin de contrastar los diferentes Estados. Resultados. La investigación permitió evidenciar que las personas adultas entre 45 y 64 años presentan el mayor porcentaje de obesidad en las diferentes regiones de Estados Unidos de Norteamérica, mientras el rango de edad entre 18 a 24 años es el grupo que posee el menor porcentaje en general. Conclusiones. El sexo masculino presenta mayores niveles de sobrepeso respecto al sexo femenino. De igual manera se observa que la obesidad se ha incrementado a lo largo del tiempo, mientras el sobrepeso ha disminuido levemente.
Catalisis, enzimas y pruebas rápidas
Authors: Corrales Ramírez Lucía Constanza , Caycedo Lozano Liliana , Quijano Duarte Stiven
Published: January 2023

Un gran número de los procesos metabólicos y biológicos son catalizados por enzimas; las enzimas son compuestos químicos orgánicos que pertenecen al grupo específico de las biomoléculas denominadas proteínas. Las enzimas poseen en su estructura molecular cuaternaria, organizaciones internas que permiten definir un lugar denominado centro activo; su función química, cinética y termodinámica se relacionan con la disminución de la energía de activación en el curso de la reacción neta.

Los mecanismos de reacción enzimáticos que suceden en las interacciones metabólicas de los microorganismos han permitido desarrollar una serie de pruebas cualitativas que determinan la presencia o ausencia de bacterias en una muestra o un cultivo haciendo uso de técnicas rápidas que facilitan el diagnóstico clínico.
Audit committee gender diversity and audit fees: The role of dual-class share structure
Authors: Omar Ayishat
Published: January 2023

The paper examines the role of dual-class share structure on the nexus between the presence of at least one female member on the audit committee (gender diversity) and audit fees. The study estimates a regression model using 2,519 firm-year observations for 475 public U.S. firms, and in line with the view that gender diversity helps firms to be more attentive and committee members act within their control to ensure a higher level of audit coverage, the study finds that gender diversity is associated with higher audit fees. Further, this study reports that the interaction of dual-class share structure and gender diversity is associated with lower audit fees. This highlights the merits of dual-class share structures which continue to be a subject of much debate. This study also contributes to the literature that provides insight into how context or situational factors moderate the impact of gender diversity on audit fees.
Revisitando un viejo debate: la irrupción política de Carlos Menem en la visión de la izquierda democrática (1990-1994)
Authors: Rossi Ignacio Andrés
Published: January 2023

Los estudios en torno al populismo han sido profusos en la historia política y la politología argentina. Desde sus consideraciones teóricas proponemos abordar una reflexión histórica sobre el carácter político del gobierno de Carlos Menem en una primera etapa comprendida entre 1990-1994, a partir de la visión de las izquierdas agrupadas en la publicación La Ciudad Futrura (lcf). Para esto, se reconstruyó históricamente el proyecto editorial de lfc y se desarrollan las discusiones en torno al populismo y el neopopulismo en América Latina. Se comprobó que la caracterización que la izquierda democrática de lcf construyó sobre la observación del fenómeno político menemista desde 1990 fue heterogénea y plural, y que la discusión en torno a sus elementos tipológicos sigue abierta en el debate histórico y político.
Otomyiasis: A case report
Authors: Mesfin Telila , seyoum kenbon , Tadesse Eshetu , Gutata Sisay , Ejigu Neway , Sadik Elias , Ayane Daniel
Published: January 2023

Abstract Myiasis is the infestation by dipteran fly larvae to feed on
the host’s organs, bodily fluids, or ingested food. We report a 14year
old grade 7 female patient who visited our hospital with a complaint of
right ear pain of two years duration. Keywords: Otomyiasis, myiasis,
aural myiasis, adult
A novel mobile health application to support cancer surveillance needs of pediatric patients and families with cancer predisposition syndromes
Authors: Mitchell Sarah , Alvarez Santiago Arconada , Pencheva Bojana , Westfall Eleanor , Mwalija Comfort , Parsell Maren , Greenleaf Morgan , Porter Christopher C , Lam Wilbur , G Robert Mannino
Published: January 2023

Background: At least 5-10% of malignancies occur secondary to
an underlying cancer predisposition syndrome (CPS). For patients with a
CPS, cancer surveillance is recommended with the goal of identifying
malignancy earlier, in a presumably more curable form. Surveillance
protocols, including imaging studies, lab work, and procedures, can be
complex, differing based on age, gender, and syndrome, which may
adversely affect adherence. Mobile health (mHealth) applications have
been utilized in the oncology field and could help to facilitate
adherence to cancer surveillance protocols. Methods: Applying a
user-centered mobile app design approach, patients with a CPS and/or
primary caregivers were interviewed to identify current methods for care
management and barriers to compliance with recommended surveillance
protocols. Broad themes from these interviews informed the design of the
mobile app, HomeTown, subsequently evaluated by usability experts. The
design was then converted into software code in phases, evaluated by
patients and caregivers in an iterative fashion. User population growth
and app usage data were assessed. Results: Common themes
identified include general distress surrounding surveillance protocol
scheduling and results, difficulty remembering medical history,
assembling a care team, and seeking resources for self-education. These
themes were translated into specific functional app features including
push reminders, syndrome-specific surveillance recommendations, ability
to annotate visits and results, storage of medical histories, and links
to reliable educational resources. Conclusions: Families with
CPS demonstrate a desire for mHealth tools to facilitate adherence to
cancer surveillance protocols, reduce related distress, relay medical
information, and provide educational resources. HomeTown may be a useful
tool for engaging this patient population.
The Wöhler Curve Method for a low/medium/high cycle fatigue of metals
Authors: yan xiangqiao
Published: January 2023

Recently, the author specifically concerned with for low-cycle fatigue
(LCF) of metals. An attempt was made that the well-known Wöhler Curve
Method was used to perform LCF assessment of metals. From the author’s
study, it is sure that the Wöhler Curve Method is well suitable for LCF
life analysis of metals, in which the stress-based intensity
parameter calculation is on the basis the linear-elastic
analysis. In view of the fact that medium/high cycle fatigue lives of
metals is well calculated by the Wöhler Curve Method, thus from the
author’s study it appears to be possible that, for low/medium/high cycle
fatigue (LHCF) of metals, the Wöhler Curve Method is well suitable for
fatigue life assessment. This study specifically concern with such a
subject. By using a number of the fatigue test data of metals from the
literature, it has been proven that, in LHCF regime, the Wöhler Curve
Method and the generalized Wöhler Curve Method are well suitably used to
perform the fatigue life assessment of metals under uniaxial and
multiaxial loading, respectively.
TRANSPIRATION RESPONSES TO POTENTIAL VOLATILE SIGNALS AND HYDRAULIC FAILURE IN SINGLE LEAVES OF VITIS VINIFERA (CV. SHIRAZ) AND ARABIDOPSIS THALIANA (COL 0) UTILISING SENSITIVE LIQUID FLOW AND SIMULTANEOUS GAS EXCHANGE.
Authors: Tyerman Steve , Balacey Suzanne L. , Capone Dimitra Liacopoulos , Sullivan Wendy
Published: January 2023

Volatile organic compounds (VOCs) may communicate stress between plants.
However little appears to be documented on how such VOCs affect
transpiration. Changes in transpiration in response to some VOCs was
examined by measurement of flow ( Q) at high resolution into
detached leaves of Vitis vinifera (cv. Shiraz) and Arabidopsis
(Col 0). Sensors recorded arrival and decay of volatiles at the leaf
lamina. Moderate xylem tensions were developed in V. vinifera
leaves by incorporating a hydraulic resistance in the flow pathway.
Simultaneous recording of leaf gas exchange (Assimilation, A, and
Transpiration, E) for both V. vinifera and Arabidopsis
revealed that for Arabidopsis Q was stochastically restricted by
the gas exchange cuvette but not E in the short term. Depending
on the applied supply pressure cavitation could be controlled in
V. vinifera evident from reduced Q, and leaf wilting.
Stomatal closure occurred upon cavitation after a transitory increase in
E and A, and after wilting began and was reversed by
re-pressurization. VOCs were emitted from leaves corresponding to
changes in flow rate, and light to dark transitions but not to
cavitation. Volatile methanol but not ethanol or methyl salicylate
induced a localised dose-dependent reversible stomatal closure in both
V. vinifera and Arabidopsis.
THE EVOLUTION OF THE ENERGY SYSTEMS OF UKRAINE AND THE ORGANIZATION OF MANAGEMENT ACCOUNTING IN ENERGY COMPANIES IN CONDITIONS OF RISK
Authors: Gutsalenko Liubov , Hutsalenko Oleksandr , Marchuk Uliana , Zabolotnyy Serhiy
Published: January 2023

An essential prerequisite for the development of Ukraine is a rationally formed energy system that covers the electricity demand of society and assures the smooth functioning of the national economy. The study presents the characteristics of different types of power plants in Ukraine, such as thermal, hydraulic, nuclear, geothermal, and tidal. Furthermore, the share of Ukraine’s contribution to the energy supply of other countries is indicated. Today, the United Energy System of Ukraine is one of Europe’s most significant energy com- plexes with seven regional electric power systems (REES), including Dnipro, Western, Crimean, Southern, Southwestern, Northern, and Central. The research presents the structure of electricity consumption by consumer groups in Ukraine. It indicates the extent of the destruction of Ukraine’s energy capacities by Russia’s invasion. The issue of developing electricity production from alternative energy sources in Ukraine is discussed. Permanent risks and the threat of destruction of energy system objects encourage managers of economic entities to carefully search for quick and accurate problem-solving tools for avoiding critical situations. The accounting system, in particular, management accounting, provides the in- formational component that satisfies the timeliness of providing boards with recommendations on making managerial decisions. The study highlights and describes the stages of implementation of management accounting in energy supply companies in Ukraine. The effectiveness of management accounting in this aspect is emphasized.
Koncentracja i specjalizacja gospodarstw rolniczych w procesie integracji z Unią Europejską
Authors: Ziętara Wojciech
Published: January 2023

W artykule przedstawiono zmiany w strukturze gospodarstw rolniczych ogółem i w gospodarstwach indywidualnych o powierzchni powyżej 1 ha w latach 2002 i 2010. Zmiany te były przejawem wzro-stu koncentracji ziemi w gospodarstwach o powierzchni powyżej 20 ha użytków rolnych. Przedsta-wiono również zmiany w liczbie i strukturze gospodarstw wyspecjalizowanych w określonych typach. Wystąpił wzrost udziału typów gospodarstw silniej wyspecjalizowanych. W latach 2004 – 2010 w tych gospodarstwach znacznie wzrosła produktywność i dochodowość czynników produkcji.
Dochodowa elastyczność wydatków polskich gospodarstw domowych i jej uwarunkowania
Authors: Laskowski Wacław
Published: January 2023

Pośród licznych czynników warunkujących poziom i strukturę konsumpcji, wiodące znaczenie ma dochód. Jest on nie tylko czynnikiem limitującym konsumpcję, ale także modulującym ją. Od ponad 50 lat GUS prowadzi systematyczne badania budżetów gospodarstw domowych. Korzystając z źródłowych rezultatów tych badań obliczono i zanalizowano wskaźniki struktury oraz wskaźniki dochodowej regresji oraz elastyczności wydatków i oszczędności. Przeprowadzono analizy oddzielnie w trzech grupach różniących się poziomem dochodu; wyróżniono grupę uboższych, średnio zamożnych i zamożnych gospodarstw domowych. Analizy pokazały, że rozdysponowanie dochodu jest zależne od jego poziomu. W gospodarstwach zamożniejszych poziom jak i udział oszczędności są zasadniczo większe, zaś reakcje wydatków na wzrost dochodu są mniejsze. Wydatki żywnościowe ogólnie wykazują średnią elastyczność, ale niektóre, np. na gastronomię, ryby, owoce, wody pitne mają elastyczność wysoką.
Rynek pracy na terenach wiejskich w krajach Unii Europejskiej
Authors: Rollnik-Sadowska Ewa
Published: January 2023

Sytuacja na rynku pracy na terenach wiejskich w krajach Unii Europejskiej jest bardzo zróżnicowana. Wyraźnie wyłania się dysproporcja pomiędzy krajami Europy Zachodniej i Środkowo-Wschodniej przechodzącymi uprzednio procesy transformacyjne. Stan ten determinowany jest głównie uwarunkowaniami demograficznymi kształtującymi strukturę podaży pracy na terenach wiejskich. Istotne są także czynniki ekonomiczne kreujące popyt na pracę, do których można na przykład zaliczyć wydajność pracy w rolnictwie, czy możliwości zatrudnienia poza rolnictwem. Nie bez znaczenia są także uwarunkowania regionalne poszczególnych obszarów określające, na przykład, ich atrakcyjność turystyczną, czy dostęp ludności wiejskiej do określonych usług i zasobów.
Krajowy rynek rzepaku na tle rynku światowego
Authors: Rosiak Ewa
Published: January 2023

Celem artykułu było przedstawienie zmian jakie nastąpiły na krajowym i światowym rynku rzepaku w pierwszych latach po akcesji Polski do UE (lata 2004-2007) i w kolejnych (lata 2008-2012), w porównaniu z okresem przed akcesją (lata 2000-2003). Ocenę tych zmian przeprowadzono na podstawie danych średniorocznych dla wybranych okresów. Wykazano, że wejście Polski do UE i polityka Unii w zakresie produkcji biopaliw i energii odnawialnej zdynamizowały rozwoju produkcji, przetwórstwa i handlu rzepakiem i produktami jego przerobu. Polska stała się częścią rynku globalnego i dlatego na wzrosty i spadki cen rzepaku na rynku krajowym znaczący wpływ mają zmiany cen surowców oleistych, które następują na europejskich, a także amerykańskich giełdach.
Światowa sytuacja na rynku jabłek w latach 1961-2010
Authors: Borowska Agnieszka
Published: January 2023

Artykuł przedstawia informacje na temat zmian zachodzących na światowym rynku jabłek świeżych w latach 1961-2010. Zwraca uwagę na przemiany zachodzące po stronie produkcyjnej, konsumpcyjnej, w handlu zagranicznym oraz cenach owoców z uwzględnieniem rozmieszczenia geograficznego głównych jego interesariuszy (producentów, konsumentów, eksporterów i importerów), w tym Polski. W opracowaniu wykorzystano wtórne źródła informacji pochodzące z baz danych Faostat, GUS. Praca została zrealizowana w ramach projektu badawczego (grantu nr 3745/B/H03/2011/40), sfinansowanego ze środków Narodowego Centrum Nauki. W analizie problemu badawczego wykorzystano metodę porównawczą oraz opisową.
Ocena zaawansowania systemów logistycznych w polskich przedsiębiorstwach produkcji żywności
Authors: Jałowiecki Piotr , Jałowiecka Ewa
Published: January 2023

W pracy przedstawiono propozycję wskaźnika syntetycznego służącego do oceny poziomu zaawansowania rozwiązań w zakresie logistyki. Wskaźnik zbudowano w oparciu o dane uzyskane w wyniku przeprowadzenia ankiety wśród 511 polskich przedsiębiorstw przetwórstwa rolno-spożywczego w latach 2010-2011. Wyznaczono podstawowe charakterystyki opisowe wskaźnika we wszystkich grupach wielkości zatrudnienia oraz branżach funkcjonowania badanych przedsiębiorstw. Zbadano również istnienie i siłę zależności pomiędzy wielkością przedsiębiorstwa oraz przynależnością do określonej branży, a poziomem zaawansowania stosowanych rozwiązań logistycznych. Stwierdzono systematyczny i znaczący wzrost zaawansowania logistyki w miarę wzrostu wielkości przedsiębiorstw. Wśród branż zdecydowanie najbardziej zaawansowana pod względem logistyki była branża mleczarska, najmniej natomiast branża piekarska.
Zmiany w wymianie handlowej Polski produktami rolno-spożywczymi z krajami pozaunijnymi
Authors: Nacewska-Twardowska Aleksandra
Published: January 2023

Analiza zmian w strukturze geograficznej i towarowej wymiany Polski z krajami pozaunijnymi wskazuje na kluczowe znaczenie przystąpienia Polski do Unii Europejskiej w 2004 roku. Wzrost obrotów handlowych towarów rolno-spożywczych, w tym przede wszystkim eksportu, umożliwił uzyskanie wyraźniej nadwyżki w handlu z krajami trzecimi. Akcesja wpłynęła także na zmiany w strukturze geograficznej, w tym w szczególności zwiększenie koncentracji oraz na zmianę głównych partnerów w imporcie.
Koncepcja wskaźnika syntetycznego oceny poziomu rozwoju gmin wiejskich województwa świętokrzyskiego w warunkach globalizacji
Authors: Dziekański Paweł
Published: January 2023

Procesy globalne sprawiają, że obszary lokalne stały się częścią ogólnoświatowego układu gospodarczego i społecznego oraz elementem procesu tworzenia się sieci powiązań i współzależności w m.in. sferze gospodarczej, technologicznej i kulturowej. Konstrukcja wskaźnika syntetycznego umożliwia pomiar wielowymiarowego zjawiska, a także liniowe uporządkowanie badanych jednostek. Pozwala ona uwzględnić wiele aspektów badanego zjawiska jednocześnie (np. finanse, infrastrukturę, stan i ochronę środowiska). Za korzyści w tym względzie uznać można kwantyfikację złożonego zjawiska za pomocą jednej wartości liczbowej. Celem opracowania była ocena poziomu rozwoju lokalnego przez ocenę kondycji finansowej, infrastruktury i środowiska naturalnego gmin wiejskich województwa świętokrzyskiego za pomocą wskaźnika syntetycznego. Województwo świętokrzyskie charakteryzuje się wyraźnym zróżnicowaniem wewnętrznym w zakresie badanych cech, a tym samym poziomie rozwoju lokalnego. Badania wskazują na pięć rodzajów gmin dobrym (Morawica), średnim (Zagnańsk, Sitkówka-Nowiny, Daleszyce, Krasocin), słabym (Piekoszów, Masłów, Łoniów, Pawłów, Stopnica, Kije) i bardzo słabym (Michałów, Klimontów, Nagłowice, Oksa, Moskorzew) poziomie rozwoju.
Wycena nieruchomości rolnych z wykorzystaniem Analitycznego Procesu Sieciowego
Authors: Kozioł-Kaczorek Dorota
Published: January 2023

Rozważanym zagadnieniem jest wycena nieruchomości rolnych i związane z nią wybrane problemy. Opisane w pracy problemy to przede wszystkim ograniczony zbiór dostępnych informacji oraz konieczność uwzględnienia w procesie wyceny zarówno charakterystyk ilościowych jak i ilościowych. Mają charakter międzynarodowy i nie wynikają wyłącznie ze specyfiki polskiego rynku nieruchomości. Dowodem na to jest wspomniana w pracy wycena plantacji brzoskwiń w Hiszpanii. Celem pracy jest przedstawienie propozycji wielokryterialnej metody wyceny za pomocą Analitycznego Procesu Sieciowego (ANP). Technika ta bowiem umożliwia uwzględnienie w procesie wyceny zarówno cech mierzalnych jak i niemierzalnych cech nieruchomości. ANP pozwala ponadto na uwzględnienie relacji zwrotnej i współzależności w procesie wyceny.
Wybrane aspekty wymiany międzynarodowej polskimi produktami spożywczymi
Authors: Stefko Olga
Published: January 2023

W artykule podjęto próbę zaprezentowania wybranych aspektów wymiany międzynarodowej produktami spożywczymi. Zestawienia statystyczne dotyczyły stanu i zmian wielkości polskiego eksportu i importu. Przedstawiono także wyniki burzy mózgów będące materiałem pierwotnym przy analizie STEEPVL. Stwierdzono, że poza czynnikami kluczowymi istnieje wiele innych warunkujących rozwój sektora i wielkość eksportu. Zaliczają się one przede wszystkim do trzech grup - czynników ekonomicznych, społecznych i prawnych.
Regional Approach to the Effects of the Production of Agricultural Holdings with Respect to the CAP Policy
Authors: Buks Joanna , Pietrzykowski Robert
Published: January 2023

The productivity is a key issue in economics as it is one of the factors affecting the economic prosperity. An analysis of the agricultural production has a special place in economics of agriculture due to its high dependency on many factors. Therefore, many authors try to define what and to what extent affects the production in agricultural holdings. In their paper, the authors wanted to show that apart from basic production inputs, we also observe an impact of various types of payments on the production. These payments are used in agricultural holdings to cover costs related to the agricultural production, e.g. purchase of fertilisers and plant protection products. In the longer term, such activity may have negative consequences, namely it may result in the stagnation of the development of a holding. This is related to providing the holding with additional funds which protect it against bankruptcy and consequently delay making a decision on reorganising the holding. The paper also attempts to approach the analysed issue in spatial terms, because, as many authors notice, changes in the production and the system of payments are strongly diversified regionally. The studies used the spatial econometrics the SAR model. Based on the above model, an econometric production model, extended by various types of payments, has been proposed.
Changes in the EU and Global Milk and Dairy Products Market in View of Multilateral Trade Liberalisation
Authors: Pawlak Karolina
Published: January 2023

The aim of this article is to present the situation of the milk and dairy products market in the EU countries and in the countries which are the world’s major milk producers in view of changes caused by the potential liberalisation of the global milk trade. The volume of trade in milk and dairy products, as well as production, demand and prices paid by consumers were analysed. The study uses the general equilibrium model of the Global Trade Analysis Project (GTAP). Projections were made according to the propositions included in the modalities negotiated at the World Trade Organisation forum in December 2008. It was proved that the progressing liberalisation of foreign trade may increase the competitive pressure both on regional markets and on the global market. In consequence, the dairy producers and processors from the EU countries may lose part of the market to the suppliers from the countries with lower costs of production. Such countries as New Zealand, the USA, Brazil and China may benefit from the liberalization.