bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing and Extending the Meta-Analytic Comparison of Newer Genre Leadership Forms
Authors: Fuller Bryan , Bajaba Abdulah , Bajaba Saleh
Published: April 2022

Interest in leadership research is growing, however, the rate of leadership learning is slowing down due to the proliferation of new leadership constructs. The objective of the present meta-analysis is to address the significant shortcomings in prior meta-analytic research on newer genre leadership forms by (a) utilizing a substantially greater number of studies and observations than in previous meta-analyses and (b) examining the meta-analytic correlations among the newer genre leadership forms. The results of the present study indicate that the newer genre leadership forms overlap to a greater degree than previously reported, while at the same time accounting for some degree of unique variance in the literature's most studied outcome variables; estimates of the relative contribution of each leadership form to the outcomes are provided, providing new insights into the distinctiveness of each leadership form. The findings suggest that pursuing an integrated theory and measure of newer genre leadership forms is a desirable future step for leadership research.
Association of Homocysteine Levels With Medial Temporal Lobe Atrophy Among Carriers and Non-carriers of APOE ε4 in MCI Subjects
Authors: Ma Jun , Ma Ling-Yun , Man FengYuan , Zhang Guili
Published: April 2022

Background

Different clinical subtypes of mild cognitive impairment (MCI) involve heterogeneous underlying etiologies. This study investigated the association between demographics, neuropsychological performance, apolipoprotein E (APOE) genotype and magnetic resonance imaging (MRI) measures in patients with MCI (amnestic [aMCI] and non-amnestic [naMCI]).

Methods

This case–control study included 130 aMCI patients, 58 naMCI patients, and 1,106 healthy controls (HCs). APOE genotypes, medial temporal lobe atrophy (MTA), neurological evaluation results, and white matter hyperintensities (WMH) were investigated. Serum folate and vitamin B12 concentrations were analyzed by radioimmunoassay, and plasma hyperhomocysteinemia (Hcy) was assessed by a high-performance liquid chromatography-fluorescence method.

Results

Serum folate levels were significantly lower, but plasma Hcy levels were higher, in patients with aMCI and naMCI than in healthy controls. There were significantly higher MTA scores in the aMCI group than the healthy control group. Multiple linear regression showed that serum Hcy and folate concentrations were positively associated with MTA (p < 0.05), while APOE4 showed a significant negative association with MTA in the aMCI group (p < 0.01). In addition, moderate/severe WMH showed a significant negative association with MTA in the naMCI and HC groups (p < 0.01).

Conclusion

The combined presence of APOE4 and Hcy is associated with aMCI in elderly individuals, while moderate/severe WMH is related to naMCI, which suggests etiological differences across MCI subtypes.
Tuina for Enuresis in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Tong Chiin , He Qida , Ho Manin , Zhong Zhenghong , Wu Qibiao , Chen Min
Published: April 2022

Objective

To evaluate the effects of Tuina (massage) vs. non-Tuina traditional Chinese medicine (TCM) treatments on nocturnal enuresis in children.

Methods

A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted following the Preferred Reported Items for Systematic Review and Meta-analysis (PRISMA) guidelines. RevMan 5.3 software was used for meta-analysis.

Results

Twelve RCTs recruiting a total of 1,007 children were included. Meta-analysis results showed that, compared with non-Tuina TCM treatments, Tuina could significantly improve the total effective rate of children's enuresis [RR = 1.29, 95%CI (1.22–1.36), P < 0.00001]. The results of subgroup analyses indicated that the total effective rate of Tuina combined with acupuncture in the treatment of nocturnal enuresis was higher than acupuncture alone [RR = 1.24, 95%CI (1.12–1.37), P < 0.0001]. The total effective rate of Tuina in the treatment of enuresis in children was better than that of herbal medicine alone [RR = 1.45, 95%CI (1.31–1.61), P < 0.00001]. The total effective rate of Tuina combined with herbal medicine in the treatment of enuresis in children was better than that of herbal medicine alone [RR = 1.16, 95%CI (1.06–1.26), P = 0.0007]. No adverse reactions of Tuina were reported in all included studies.

Conclusion

From the available evidence, Tuina, or Tuina combined with non-Tuina TCM treatments (acupuncture, or herbal medicine) can improve the clinical outcome of children with enuresis, indicating Tuina is a promising treatment choice for children's enuresis. However, because of the intrinsic limitations of the included studies, more high-quality randomized controlled trials with longer follow-up are still needed to further confirm the efficacy and safety of Tuina in the treatment of nocturnal enuresis in children.
Associations Between Income Status and Perceived Barriers to Using Long-Acting Reversible Contraception: An Exploratory Study
Authors: Henke Leah , Martins Summer , Boraas Christy
Published: April 2022

Introduction

Barriers to long-acting reversible contraception (LARC) use in the United States have been described in prior studies, but few have focused on women's income status. We explored associations between income status and perceived LARC barriers in a community-based sample of reproductive-aged women.

Methods

Non-pregnant, heterosexually active women aged 18 to 40 years completed a cross-sectional survey at a large community event in the Midwestern U.S. in 2018. Outcome measures were comprised of 26 survey items gauging perceived barriers to LARC use (e.g., access barriers, side effects). We estimated crude and age-adjusted prevalence ratios (PRs) for each outcome by participants' income status: low-income (≤ 200% of federal poverty guideline) versus higher income.

Results

Low-income women (n = 72) were significantly more likely than higher income women (n = 183) to endorse 11 of the 26 barriers to LARC use (PR range, 1.23–7.63). Cost of LARC was the most frequently identified access barrier and was more acute for low-income women (PR 1.57, 95% CI 1.17–2.11). After adjustment for age, most associations were attenuated. However, low-income women were still more likely to report concerns about LARC use due to family expectations or beliefs (aPR 3.69, 95% CI 1.15–11.8).

Conclusion

Low-income women perceive more barriers to LARC access and more negative perceptions about use. While these associations also correlate with age, they nonetheless reflect concerns that impact contraceptive equity. Efforts to increase LARC access should address these barriers and focus on concerns more common among low-income women regarding LARC use.
Research on the Sustainable Development of Urban Night Tourism Economy: A Case Study of Shenzhen City
Authors: Zhang Rui , Chen Sirong , Xu Shaogui , Law Rob , Zhang Mu
Published: April 2022

As the process of cultural tourism integration gradually deepens, determining how to tap into the night tourism economy has become a new focus of the industry. Among the core cities in the Guangdong-Hong Kong-Macao Greater Bay Area, Hong Kong, and Macau have formed a more mature model of sustainable development of night tourism economy, whereas it is not obvious in mainland cities. The current research themes in this field are more scattered and have not yet formed a study with depth and breadth. Accordingly, this study selects the modern international metropolis Shenzhen as the research object. First, based on system theory and sustainable development theory, it uses hierarchical analysis and a comprehensive evaluation model to conduct a comprehensive assessment of the sustainable development of the tourism economy in Shenzhen from 2011 to 2021. Second, through the cluster analysis of day-time and night-time tourism economic patterns in Shenzhen, it explores the sustainable development path of Shenzhen's night-time tourism economy. Research results show that each major indicator of sustainable development of the tourism economy in Shenzhen maintains stable and fast growth momentum, and the rise of the night-time tourism economy injects a new momentum for sustainable development. As an extension and supplement of the day-time tourism economic form, the night-time tourism economy includes three tourism economic forms: excursionistic, cultural immersion, and host and guest leisure. Finally, the researcher proposes corresponding sustainable development strategies for different forms of the night-time tourism economy. Empirical findings of this study have important reference value for the related research on the night tourism economy.
Investigating the Social Network Structure of Physical Literacy Scholars to Advance a Paradigm for Physical Activity Promotion
Authors: Lower-Hoppe Leeann M. , Kim Amy Chan Hyung , Brgoch Shea M. , Zwolski Christin M. , Schmitt Laura , Paponetti Matthew K. , Quatman-Yates Catherine C.
Published: April 2022

Purpose

Physical literacy has quickly gained global attention as a holistic approach to combat physical inactivity and obesity. However, research silos may limit the growth and application of the physical literacy paradigm for effective physical activity promotion. The purpose of this study was to measure the underlying network structure of scholars publishing on physical literacy (focusing on empirical research) through co-authorship analysis.

Methods

Data collection resulted in 1,070 documents related to physical literacy retrieved. A total of 198 articles met inclusion criteria and were included in the full network, with authors operationalized as actors in the network. A total of 75 empirical studies were included in the sub-network for critical appraisal and further analysis. Social network analysis was then conducted at the macro- and component-level, using quantification and visualization techniques.

Results

Results revealed a collaborative, yet fragmented physical literacy network with sub-groups representing substantive and geographically diverse scholars. The majority of scholarship lacked empirical evidence, suggesting a research-practice gap.

Conclusion

Recommendations for advancing physical literacy research and practice include strategic collaborations that transcend geographic and disciplinary boundaries, cooperative efforts across scholars and practitioners, and productive discourse through professional avenues to progress knowledge generation, dispersion, and application.
Trans-Nasion-Complex Approach for Endoscopic Modified Lothrop Procedure: Conception, Anatomy, and Technique
Authors: Zhao Yu , Liu Jianfeng , Yang Dazhang , Han Jun , Zhao Jianhui , Wang Yibei
Published: April 2022

Background

The endoscopic modified Lothrop procedure (EMLP) is an important procedure used to address frontal and anterior skull-base lesions. Two techniques were established, namely, the inside-out approach and the outside-in approach. The former technique take the frontal recess and the first olfactory filament (FOF) as key landmarks while the latter use the FOF as posterior boundary. In some cases, however, these two landmarks are not available. Therefore, we supplement the outside-in approach and named it trans-nasion-complex approach (TNCA) for EMLP that can be performed without locating these two landmarks.

Methods

Two dry human skulls were used to observe the bony nasion complex. Then, five colored silicon-injected human head specimens were dissected via TNCA for EMLP. Finally, the outcomes of patients who underwent TNCA were reviewed.

Results

The nasion complex is an osseous complex that consists of the nasion and its adjacent structures, including the bilateral root of nasal bones, nasal process of frontal bones, anterior portion of the perpendicular plate of the ethmoid bone that connects with the inferior aspect of the nasal bones, and portions of the bilateral frontal process of the maxillary bones. Surgical landmarks for TNCA include the anterior superior portion of the nasal septum, anterior margin and axilla of the middle turbinate, frontal process of the maxilla bone, nasal process of the frontal bone and upper part of the nasal bone. These structures form a “mushroom sign” during cadaveric dissection and surgery. Twenty-one patients underwent TNCA, of whom 9 had tumors and 12 had chronic rhinosinusitis with nasal polyps (CRSwNP). None of them had major complications.

Conclusion

TNCA is expected to be a safe, and direct route for EMLP. Adequate understanding of the nasion complex and “mushroom sign” will be helpful to complete TNCA.
Risk Factors for Chronic Stress in Sows Housed in Groups, and Associated Risks of Prenatal Stress in Their Offspring
Authors: Lagoda Martyna Ewa , Marchewka Joanna , O'Driscoll Keelin , Boyle Laura Ann
Published: April 2022

Chronic stress has a detrimental effect on sow welfare and productivity, as well as on the welfare and resilience of their piglets, mediated prenatally. Despite this, the specific risk factors for chronic stress in pregnant sows are understudied. Group-housed pregnant sows continuously face numerous challenges associated with aspects of the physical (group type and size, flooring, feeding system) and social (stocking density, mixing strategy) environment. There are many well-known potent stressors for pigs that likely contribute to chronic, physiological stress, including overcrowding, hot temperatures, feed restriction, inability to forage, uncomfortable floors, and poor handling. Some of these stressors also contribute to the development of production diseases such as lameness, which in turn are also likely causes of chronic stress because of the associated pain and difficulty accessing resources. The aim of this review is to discuss potential risk factors for chronic stress in pregnant sows such as space allowance, group size and type (stable/dynamic), feeding level, lameness, pen design, feed system, enrichment and rooting material, floor type, the quality of stockmanship, environmental conditions, and individual sow factors. The mechanisms of action of both chronic and prenatal stress, as well as the effects of the latter on offspring are also discussed. Gaps in existing research and recommendations for future work are outlined.
On the Feasibility of a Launcher-Deployable High-Altitude Airship: Effects of Design Constraints in an Optimal Sizing Framework
Authors: Riboldi Carlo E.D. , Rolando Alberto , Regazzoni Gregory
Published: April 2022

When ground observation or signal relaying in the vicinity of an unfriendly operative scenario are of interest, such as for military actions or disaster relief, high-altitude airships (HAA) offer some technical benefits. Featuring a milder cost and higher deployment flexibility with respect to lower-Earth orbit satellites, these platforms, often baptized as high-altitude pseudo-satellites (HAPS), operate sufficiently far from the ground to provide better imaging coverage and farther-reaching signal relaying than standard low-flying systems, such as aircraft or helicopters. Despite the atmospheric conditions in the higher atmosphere, they offer stable airstreams and highly-predictable solar energy density, thus ideally giving the chance of smooth operation for a prolonged period of time. The design of airships for the task is often conditioned by the need to go through the lower layers of the atmosphere, featuring less predictable and often unstable aerodynamics, during the climb to the target altitude. With the aim of simultaneously largely increasing the ease and quickness of platform deployment, removing most of the design constraints for the HAPS induced by the crossing of the lower atmosphere, and thus allowing for the design of a machine best suited to matching optimal performance at altitude, the deployment of the HAA by means of a missile is an interesting concept. However, since the HAA platform should take the role of a launcher payload, the feasibility of the mission is subject to a careful negotiation of specification, such that the ensuing overall weight of the airship is as low as possible. A preliminary design technique for high-altitude airships is therefore introduced initially, customized to some features typical to missile-assisted deployment, but with the potential for broader applications. The proposed procedure bends itself to the inclusion in an optimal framework, with the aim of seeking a design solution automatically. A validation of the adopted models and assumptions on existing HAPS is proposed first. The design of the airship is then carried out in a parameterized fashion, highlighting the impact of operative and technological constraints on the resulting sizing solutions. This allows for the marking of the boundaries of the space of design solutions for a launcher-deployable airship.
Resilience of Agri-Food Systems
Authors: Copeland Les
Published: April 2022

Agriculture was launched in June 2011 as a scholarly, open access journal for publishing research covering the breadth of the agriculture value chain from an international perspective [...]
Enhancing Genomic Prediction Models for Forecasting Days to Maturity in Soybean Genotypes Using Site-Specific and Cumulative Photoperiod Data
Authors: Persa Reyna , Graef George L. , Specht James E. , Rios Esteban , Messina Charlie D. , Jarquin Diego
Published: April 2022

Genomic selection (GS) has revolutionized breeding strategies by predicting the rank performance of post-harvest traits via implementing genomic prediction (GP) models. However, predicting pre-harvest traits in unobserved environments might produce serious biases. In soybean, days to maturity (DTM) represents a crucial stage with a significant impact on yield potential; thus, genotypes must be carefully selected to ensure latitudinal adaptation in this photoperiod-sensitive crop species. This research assessed the use of daylength for predicting DTM in unobserved environments (CV00). A soybean dataset comprising 367 genotypes spanning nine families of the Soybean Nested Association Mapping Panel (SoyNAM) and tested in 11 environments (year-by-location combinations) was considered in this study. The proposed method (CB) returned a root-mean-square error (RMSE) of 5.2 days, a Pearson correlation (PC) of 0.66, and the predicted vs. observed difference in the environmental means (PODEM) ranged from −3.3 to 4.5 days; however, in the absence of daylength data, the conventional GP implementation produced an RMSE of 9 days, a PC of 0.66, and a PODEM range from −14.7 to 7.9 days. These results highlight the importance of dissecting phenotypic variability (G × E) based on photoperiod data and non-predictable environmental stimuli for improving the predictive ability and accuracy of DTM in soybeans.
Salt Tolerance Strategies of Nitraria tangutorum Bobr. and Elaeagnus angustifolia Linn. Determine the Inoculation Effects of Microorganisms in Saline Soil Conditions
Authors: Pan Jing , Xue Xian , Huang Cuihua , Peng Fei , Liao Jie , Ma Shaoxiu , You Quangang , Wang Tao
Published: April 2022

Increasing salinization threatens the normal growth of halophytes in saline habitats, especially at the seedling stage. Soil beneficial microorganisms have the potential to promote salt tolerance of halophytes, but less attention has been paid to the various responses between different halophytes with microbial inoculations. Here we performed pot experiments to assess the responses of Nitraria tangutorum Bobr. and Elaeagnus angustifolia Linn. to arbuscular mycorrhizal fungi (AMF) and plant growth-promoting rhizobacteria (PGPR) inoculation in saline soil conditions. The results showed that neither a single AMF inoculation nor a single PGPR inoculation promoted the growth of N. tangutorum. In contrast, co-inoculation not only promoted biomass accumulation but also promoted the absorption of P, K+, and Ca2+ in the roots, and the accumulation of N, Na+, K+, and Ca2+ in the leaves. Co-inoculation also increased the K+/Na+ ratio in the roots as well as the Ca2+/Na+ ratio in both roots and leaves of N. tangutorum. Na+ is an important inorganic osmolyte, essential for both efficient osmoregulation and biomass accumulation in N. tangutorum. PGPR inoculation alone could not promote the growth of E. angustifolia. AMF inoculation, solely or combined with PGPR, was beneficial to the absorption of K+ and Ca2+ in the roots, the accumulation of N and K+ in the leaves, the maintenance of the K+/Na+ ratio and Ca2+/Na+ ratio in the leaves, the selective transportation of K+ and Ca2+ from roots to leaves, and the accumulation of proline and glycine betaine in the leaves of E. angustifolia. Increased nutrient absorption, ion homeostasis, and K+ and Ca2+ selective transportation in AMF-inoculated E. angustifolia helped reduce the toxic effects of Na+ and the damage caused by osmotic stress in saline soil conditions. “Plant-microbe specificity” leads to the different responses of N. tangutorum and E. angustifolia seedlings to AMF and PGPR inoculation in saline soil conditions. The different salt tolerance strategies for osmoregulation, nutrient acquisition, ion homeostasis, and ion transportation determine the differential responses in N. tangutorum and E.angustifolia to AMF and PGPR inoculations under saline soil conditions.
Mitochondrial Generated Redox Stress Differently Affects the Endoplasmic Reticulum of Circulating Lymphocytes and Monocytes in Treatment-Naïve Hodgkin’s Lymphoma
Authors: Marini Cecilia , Cossu Vanessa , Bauckneht Matteo , Carta Sonia , Lanfranchi Francesco , D’Amico Francesca , Ravera Silvia , Orengo Anna Maria , Ghiggi Chiara , Ballerini Filippo , Durando Paolo , Chiesa Sabrina , Miceli Alberto , Donegani Maria Isabella , Morbelli Silvia , Bruno Silvia , Sambuceti Gianmario
Published: April 2022

Background. The redox stress caused by Hodgkin’s lymphoma (HL) also involves the peripheral blood mononucleated cells (PBMCs) even before chemotherapy. Here, we tested whether lymphocytes and monocytes show a different response to the increased mitochondrial generation of reactive oxygen species (ROS). Methods. PBMCs, isolated from the blood of treatment-naïve HL patients and control subjects, underwent assessment of malondialdehyde content and enzymatic activity of both hexose- and glucose-6P dehydrogenase (H6PD and G6PD) as well as flow cytometric analysis of mitochondrial ROS content. These data were complemented by evaluating the uptake of the fluorescent glucose analogue 2-NBDG that is selectively stored within the endoplasmic reticulum (ER). Results. Malondialdehyde content was increased in the whole population of HL PBMCs. The oxidative damage matched an increased activity of G6PD, and even more of H6PD, that trigger the cytosolic and ER pentose phosphate pathways, respectively. At flow cytometry, the number of recovered viable cells was selectively decreased in HL lymphocytes that also showed a more pronounced increase in mitochondrial ROS generation and 2-NBDG uptake, with respect to monocytes. Conclusions. PBMCs of HL patients display a selective mitochondrial and ER redox stress most evident in lymphocytes already before the exposure to chemotherapy toxicity.
Detection of Logos of Moving Vehicles under Complex Lighting Conditions
Authors: Zhao Qiang , Guo Wenhao
Published: April 2022

This study proposes a method for vehicle logo detection and recognition to detect missing and inaccurate vehicle marks under complex lighting conditions. For images acquired in complex light conditions, adaptive image enhancement is used to improve the accuracy of car sign detection by more than 2%; for the problems of multi-scale and detection speed of vehicle logo recognition in different images, the paper improves the target detection algorithm to improve the detection accuracy by more than 3%. The adaptive image enhancement algorithm and improved You Only Look One-level Feature (YOLOF) detection algorithm proposed in this study can effectively improve the correct identification rate under complex lighting conditions.
Creating a Novel Mathematical Model of the Kv10.1 Ion Channel and Controlling Channel Activity with Nanoelectromechanical Systems
Authors: Lozanović Šajić Jasmina , Langthaler Sonja , Baumgartner Christian
Published: April 2022

The use of nanoelectromechanical systems or nanorobots offers a new concept for sensing and controlling subcellular structures, such as ion channels. We present here a novel method for mathematical modeling of ion channels based on control system theory and system identification. We investigated the use of nanoelectromechanical devices to control the activity of ion channels, particularly the activity of the voltage-gated ion channel Kv10.1, an important channel in cancer development and progression. A mathematical model of the dynamic behavior of the selected ion channel Kv10.1 in the Laplace (s) domain was developed, which is given in the representation of a transfer function. In addition, we addressed the possibilities of controlling ion channel activity by nanoelectromechanical devices and nanorobots and finally presented a control algorithm for the Kv10.1 as a control object. A use case demonstrates the potential of a Kv10.1 controlled nanorobot for cancer treatment at a single-cell level.
A Predictive Model for Student Achievement Using Spiking Neural Networks Based on Educational Data
Authors: Liu Chuang , Wang Haojie , Du Yingkui , Yuan Zhonghu
Published: April 2022

Student achievement prediction is one of the most important research directions in educational data mining. Student achievement directly reflects students’ course mastery and lecturers’ teaching level. Especially for the achievement prediction of college students, it not only plays an early warning and timely correction role for students and teachers, but also provides a method for university decision-makers to evaluate the quality of courses. Based on the existing research and experimental results, this paper proposes a student achievement prediction model based on evolutionary spiking neural network. On the basis of fully analyzing the relationship between course attributes and student attributes, a student achievement prediction model based on spiking neural network is established. The evolutionary membrane algorithm is introduced to learn hyperparameters of the model, so as to improve the accuracy of the model in predicting student achievement. Finally, the proposed model is used to predict student achievement on two benchmark student datasets, and the performance of the prediction model proposed in this paper is analyzed by comparing with other experimental algorithms. The experimental results show that the model based on spiking neural network can effectively improve the prediction accuracy of student achievement.
UCA-EHAR: A Dataset for Human Activity Recognition with Embedded AI on Smart Glasses
Authors: Novac Pierre-Emmanuel , Pegatoquet Alain , Miramond Benoît , Caquineau Christophe
Published: April 2022

Human activity recognition can help in elderly care by monitoring the physical activities of a subject and identifying a degradation in physical abilities. Vision-based approaches require setting up cameras in the environment, while most body-worn sensor approaches can be a burden on the elderly due to the need of wearing additional devices. Another solution consists in using smart glasses, a much less intrusive device that also leverages the fact that the elderly often already wear glasses. In this article, we propose UCA-EHAR, a novel dataset for human activity recognition using smart glasses. UCA-EHAR addresses the lack of usable data from smart glasses for human activity recognition purpose. The data are collected from a gyroscope, an accelerometer and a barometer embedded onto smart glasses with 20 subjects performing 8 different activities (STANDING, SITTING, WALKING, LYING, WALKING_DOWNSTAIRS, WALKING_UPSTAIRS, RUNNING, and DRINKING). Results of the classification task are provided using a residual neural network. Additionally, the neural network is quantized and deployed on the smart glasses using the open-source MicroAI framework in order to provide a live human activity recognition application based on our dataset. Power consumption is also analysed when performing live inference on the smart glasses’ microcontroller.
Pollution Characteristics and Health Risk Assessment of VOCs in Jinghong
Authors: Shi Jianwu , Bao Yuzhai , Xiang Feng , Wang Zhijun , Ren Liang , Pang Xiaochen , Wang Jian , Han Xinyu , Ning Ping
Published: April 2022

In order to investigate the seasonal variation in chemical characteristics of VOCs in the urban and suburban areas of southwest China, we used SUMMA canister sampling in Jinghong city from October 2016 to June 2017. Forty-eight VOC species concentrations were analyzed using atmospheric preconcentration gas chromatography–mass spectrometry (GC–MS), Then, regional VOC pollution characteristics, ozone formation potentials (OFP), source identity, and health risk assessments were studied. The results showed that the average concentration of total mass was 144.34 μg·m−3 in the urban area and 47.81 μg·m−3 in the suburban area. Alkanes accounted for the highest proportion of VOC groups at 38.11%, followed by olefins (36.60%) and aromatic hydrocarbons (25.28%). Propane and isoprene were the species with the highest mass concentrations in urban and suburban sampling sites. The calculation of OFP showed that the contributions of olefins and aromatic hydrocarbons were higher than those of alkanes. Through the ratio of specific species, the VOCs were mainly affected by motor vehicle exhaust emissions, fuel volatilization, vegetation emissions, and biomass combustion. Combined with the analysis of the backward trajectory model, biomass burning activities in Myanmar influenced the concentration of VOCs in Jinghong. Health risk assessments have shown that the noncarcinogenic risk and hazard index of atmospheric VOCs in Jinghong were low (less than 1). However, the value of the benzene cancer risk to the human body was higher than the safety threshold of 1 × 10−6, showing that benzene has carcinogenic risk. This study provides effective support for local governments formulating air pollution control policies.
Population Health Risks Assessment from Air Pollution Exposure in an Industrialized Residential Area in Greece
Authors: Pachoulis Michail , Maggos Thomas , Panagopoulos Panagiotis , Dasopoulou Maria , Balla Dimitra , Stamatelopoulou Asimina , Manousakas Manousos Ioannis , Eleftheriadis Konstantinos , Saraga Dikaia
Published: April 2022

Industrial activities nearby residential areas lead to poor local air quality. Therefore, short-term exposure to an aggravated environment and the subsequent health effects should be the subject of further research. The purpose of this study is to estimate the health risks resulting from such exposure in population groups living in an industrialized area. The risk estimation was performed using different approaches suggested in relative literature. Monitoring of the air quality in an industrial zone of Attica was carried out including 24-h measurements of PM2.5 and analysis of their chemical composition for Polycyclic Aromatic Hydrocarbons and heavy metals (Pb, Cd, As, Ni, Hg, Cu, Zn). Samples of Volatile Organic Compounds were also collected. Health effects on different population subgroups were estimated for the targeted pollutants through different mathematical approaches provided by the literature, taking into consideration different parameters (e.g., age, gender, exposure duration). Inhalation rate and body weight were important parameters to estimate the exposure dose of people, and they can vary greatly depending on the age, gender, and daily activity of the person under consideration. The results indicated that the risk for potential carcinogenic and non-carcinogenic effects varies depending on the applied methodology. In any case, the acceptable limits for cancer risk provided by the OEHHA, EPA, and WHO were not exceeded.
Insight on Poleward Moisture and Energy Transport into the Arctic from ERA5
Authors: Sun Weifu , Liang Yu , Bi Haibo , Zhao Yujia , Meng Junmin , Zhang Jie
Published: April 2022

With the new-generation reanalysis product (ERA5), the spatiotemporal characteristics of poleward atmospheric moisture and energy transport over the past four decades (1979–2020) were examined. The main channels of atmospheric transport entering the Arctic in the Northern Hemisphere include the Chukchi Sea at 170° W, Baffin Bay at 50° W, North Atlantic at 0° E, and central Siberia at 90° E. Summer (winter) is characterized by high moisture (energy) transport across 70° N. No clear trend in moisture transport was found, whereas the winter and spring energy transport are declining significantly at a rate of −7.31 × 105 W/m/a (99% confidence) and −6.04 × 105 W/m/a (95% confidence), respectively. Meanwhile, an increasing trend was found in summer (4.48 × 105 W/m/a, 95% confidence) and autumn (3.61 × 105 W/m/a, not significant). The relationship between atmospheric moisture and energy transport and different large-scale atmospheric circulation patterns, including the Arctic Oscillation (AO), North Atlantic Oscillation (NAO), and Dipole Anomaly (DA), was explored. Among them, DA was identified as the most favorable pattern in relation to moisture and/or energy intrusion into the Arctic. As a result, the surface air temperature increases are more pronounced over most of the central Arctic under the regulation of DA.
Fractional Modelling and Optimal Control of COVID-19 Transmission in Portugal
Authors: Rosa Silvério , Torres Delfim F. M.
Published: April 2022

A fractional-order compartmental model was recently used to describe real data of the first wave of the COVID-19 pandemic in Portugal [Chaos Solitons Fractals 144 (2021), Art. 110652]. Here, we modify that model in order to correct time dimensions and use it to investigate the third wave of COVID-19 that occurred in Portugal from December 2020 to February 2021, and that has surpassed all previous waves, both in number and consequences. A new fractional optimal control problem is then formulated and solved, with vaccination and preventive measures as controls. A cost-effectiveness analysis is carried out, and the obtained results are discussed.
Improvement of Peri-Implant Repair in Estrogen-Deficient Rats Fed a Cafeteria Diet and Treated with Risedronate Sodium
Authors: Ervolino da Silva Ana Cláudia , de Souza Batista Fábio Roberto , Hassumi Jaqueline Suemi , Pitol Palin Letícia , Monteiro Naara Gabriela , Frigério Paula Buzo , Okamoto Roberta
Published: April 2022

(1) Background: Postmenopausal osteoporosis combined with an unhealthy lifestyle can lead to the development of metabolic syndrome, a common condition in individuals requiring oral rehabilitation. Bisphosphonates are used to increase bone mineral density. However, further studies are needed to evaluate the action of this drug on the bone repair process in the jaws. The aim of this study was to evaluate the peri-implant repair of rats with estrogen deficiency and metabolic syndrome treated with risedronate sodium. (2) Methods: Twenty-four female Wistar rats were divided into three groups: SHAM: sham surgery; OVX/SM: ovariectomy combined with a cafeteria diet; OVX/SM/RIS: ovariectomy associated with a cafeteria diet and treatment with sodium risedronate. After 30 days, the animals underwent extraction of the upper first molars. Thirty days after the extraction, an implant was installed in the same region. Sixty days after the implant was installed, the animals were euthanized for biomechanical analysis and confocal microscopic analysis. After confirming the normal distribution of the sample data, a one-way ANOVA test was performed, followed by Tukey’s post-test, with a 5% significance level. (3) Results: Significant bone preservation was observed in the risedronate-treated group. Higher removal torque values were obtained by the risedronate-treated group. (4) Conclusions: Better biomechanical performance of the implants installed in the animals treated with risedronate sodium was observed.
Aerobic Dance on an Air Dissipation Platform Improves Cardiorespiratory, Muscular and Cellular Fitness in the Overweight and Obese Elderly
Authors: Moreira-Reis Alessandra , Maté-Muñoz José Luis , Hernández-Lougedo Juan , Vilches-Sáez Sergio , Benet Marta , García-Fernández Pablo , Pleguezuelos Eulogio , Carbonell Teresa , Alva Norma , Garnacho-Castaño Manuel Vicente
Published: April 2022

Background: Obesity is a global health problem associated with a high number of comorbidities that decrease functional capacity, especially in elderly people. Aerobic dance is considered a viable strategy to prevent the effects of aging, mainly in obese and overweight elderly people. This study aimed to evaluate the effects of aerobic dance on an air dissipation platform (ADP) on body composition, oxidative stress and muscular and cardiorespiratory fitness in elderly people. Methods: In total, 32 elderly adults (67.1 ± 3.6) were divided into 3 groups based on body mass index: healthy (HG), overweight (OWG) and obese (OG). Training program of aerobic dance on an ADP was carried out twice a week for 12 weeks. Results: OWG (p = 0.016) and OG decreased their weight (p < 0.001). There was a significant decrease in malondialdehyde concentrations in all experimental groups (p < 0.05). OWG and OG significantly improved their peak oxygen uptake (p < 0.01). HG increased the vertical jump height (p < 0.05), and HG and OG improved the power output of the lower extremities (p < 0.05). Conclusions: The aerobic dance on an ADP may be an effective alternative to lose weight, prevent oxidative stress and improve cardiorespiratory fitness in obese and overweight elderly people.
Apothecial Ancestry, Evolution, and Re-Evolution in Thelebolales (Leotiomycetes, Fungi)
Authors: Quijada Luis , Matočec Neven , Kušan Ivana , Tanney Joey B. , Johnston Peter R. , Mešić Armin , Pfister Donald H.
Published: April 2022

Closed cleistothecia-like ascomata have repeatedly evolved in non-related perithecioid and apothecioid lineages of lichenized and non-lichenized Ascomycota. The evolution of a closed, darkly pigmented ascoma that protects asci and ascospores is conceived as either an adaptation to harsh environmental conditions or a specialized dispersal strategy. Species with closed ascomata have mostly lost sterile hymenial elements (paraphyses) and the capacity to actively discharge ascospores. The class Leotiomycetes, one of the most speciose classes of Ascomycota, is mainly apothecioid, paraphysate, and possesses active ascospore discharge. Lineages with closed ascomata, and their morphological variants, have evolved independently in several families, such as Erysiphaceae, Myxotrichaceae, Rutstroemiaceae, etc. Thelebolales is a distinctive order in the Leotiomycetes class. It has two widespread families (Thelebolaceae, Pseudeurotiaceae) with mostly closed ascomata, evanescent asci, and thus passively dispersed ascospores. Within the order, closed ascomata dominate and a great diversity of peridia have evolved as adaptations to different dispersal strategies. The type genus, Thelebolus, is an exceptional case of ascomatal evolution within the order. Its species are the most diverse in functional traits, encompassing species with closed ascomata and evanescent asci, and species with open ascomata, active ascospore discharge, and paraphyses. Open ascomata were previously suggested as the ancestral state in the genus, these ascomata depend on mammals and birds as dispersal agents. In this scheme, species with closed ascomata, a lack of paraphyses, and passive ascospore discharge exhibit derived traits that evolved in adaptation to cold ecosystems. Here, we used morphological and phylogenetic methods, as well as the reconstruction of ancestral traits for ascomatal type, asci dehiscence, the presence or absence of paraphyses, and ascospore features to explore evolution within Thelebolales. We demonstrate the apothecial ancestry in Thelebolales and propose a new hypothesis about the evolution of the open ascomata in Thelebolus, involving a process of re-evolution where the active dispersal of ascospores appears independently twice within the order. We propose a new family, Holwayaceae, within Thelebolales, that retains the phenotypic features exhibited by species of Thelebolus, i.e., pigmented capitate paraphyses and active asci discharge with an opening limitation ring.
Decapeptide from Potato Hydrolysate Induces Myogenic Differentiation and Ameliorates High Glucose-Associated Modulations in Protein Synthesis and Mitochondrial Biogenesis in C2C12 Cells
Authors: Chen Yi-Ju , Baskaran Rathinasamy , Chang Ching Fang , Mohammedsaleh Zuhair M. , Lin Wan-Teng
Published: April 2022

Sarcopenia is characterized as an age-related loss of muscle mass that results in negative health consequences such as decreased strength, insulin resistance, slowed metabolism, increased body fat mass, and a substantially diminished quality of life. Additionally, conditions such as high blood sugar are known to further exacerbate muscle degeneration. Skeletal muscle development and regeneration following injury or disease are based on myoblast differentiation. Bioactive peptides are biologically active peptides found in foods that could have pharmacological functions. The aim of this paper was to investigate the effect of decapeptide DI-10 from the potato alcalase hydrolysate on myoblast differentiation, muscle protein synthesis, and mitochondrial biogenesis in vitro. The treatment of C2C12 myoblasts with DI-10 (10 µg/mL) did not induce cell death. DI-10 treatment in C2C12 myoblast cells accelerates the phosphorylation of promyogenic kinases such as ERK, Akt and mTOR proteins in a dose-dependent manner. DI-10 improves myotubes differentiation and upregulates the expression of myosin heavy chain (MyHC) protein in myoblast cells under differentiation medium with high glucose. DI-10 effectively increased the phosphorylation of promyogenic kinases Akt, mTOR, and mitochondrial-related transcription factors AMPK and PGC1α expression under hyperglycemic conditions. Further, decapeptide DI-10 decreased the expression of Murf1 and MAFbx proteins, which are involved in protein degradation and muscle atrophy. Our reports support that decapeptide DI-10 could be potentially used as a therapeutic candidate for preventing muscle degeneration in sarcopenia.
A Novel Full-length IgG Recombinant Antibody Highly Specific to Clothianidin and Its Application in Immunochromatographic Assay
Authors: Chang Yunyun , Chen Yang , Jiao Shasha , Lu Xinying , Fang Yihua , Liu Yihua , Zhao Ying , Zhan Xiuping , Zhu Guonian , Guo Yirong
Published: April 2022

The toxicity of clothianidin to non-target organisms has gradually attracted world-wide attention. It is essential to develop reliable methods for the on-site detection of clothianidin residue. In this study, analogue-based heterologous ic-ELISAs were designed to rapidly screen desirable hybridomas, which could be used for the construction of recombinant antibodies (RAbs) against clothianidin. Based on the antibody variable region genes, two full-length IgG RAbs (1F7-RAb and 5C3-RAb) were produced by the mammalian cell expression system. The performance of the two RAbs was characterized and compared by heterologous ic-ELISAs and non-competitive surface plasmon resonance (SPR) assays. Using heterologous ic-ELISAs, the 1F7-RAb exhibited highly specific and sensitive recognition to clothianidin with an IC50 of 4.62 μg/L, whereas the 5C3-RAb could bind to both clothianidin and dinotefuran. The results of the non-competitive SPR assay further verified that the 1F7-RAb had a higher specificity and affinity to clothianidin than the 5C3-RAb. Finally, a gold immunochromatographic assay based on the novel antibody, 1F7-RAb, was developed for rapid detection of clothianidin with high sensitivity (visual detection limit of 2.5 μg/L), specificity, and good reproducibility, which can be used as an effective supervision tool for clothianidin residue in agricultural and environmental samples.
Non-Invasive Breath Analysis for Disease Screening and Diagnoses
Authors: Jung Hyun Jin , Priefer Ronny
Published: April 2022

Lower respiratory infections are a deadly communicable disease ranked as the fourth leading cause of death globally, with nearly 2 [...]
Climate Chamber Experiment Study on the Association of Turning off Air Conditioning with Human Thermal Sensation and Skin Temperature
Authors: Jian Yiwen , Liu Shuwei , Bian Mengmeng , Liu Zijia , Liu Shengjie
Published: April 2022

To date, few attempts have been made to associate air conditioning behavior with environmental conditions and the occupants’ thermal sensations and physiological states simultaneously. In this study, a series of experiments were conducted in a climate chamber environment, representative of a typical intermittent air conditioning process in residences. For 29 participants, local skin temperatures, thermal sensation and the participants’ intention of turning off air conditioning were recorded continually. Skin temperature and thermal sensation were found to keep decreasing over time, which in turn triggered turning off air conditioning. It is also noted that participants reported different thermal sensations when they intended to turn off air conditioning. However, there was no statistically significant difference in skin temperature of exposed body parts such as foot and calf. Additionally, given the ambient set temperature, the probability of turning off air conditioning exponentially increased with the increasing air conditioning duration. Accordingly, from a physiological perspective, the occupants’ behavior of turning off air conditioning was largely dependent on the local skin temperature of exposed body parts. From an environmental perspective, air conditioning duration demonstrated influences on the air conditioner switch-off. The lower the ambient temperature or the longer the exposure to air conditioning environment, the stronger the intention of the participants to turn off air conditioning.
Healthcare Resource Utilization among Patients between 60–75 Years with Secondary Acute Myeloid Leukemia Receiving Intensive Chemotherapy Induction: A Spanish Retrospective Observational Study
Authors: Solana-Altabella Antonio , Megías-Vericat Juan Eduardo , Ballesta-López Octavio , Boluda Blanca , Cano Isabel , Acuña-Cruz Evelyn , Rodríguez-Veiga Rebeca , Torres-Miñana Laura , Sargas Claudia , Sanz Miguel Á. , Borrell-García Carmela , López-Briz Eduardo , Poveda-Andrés José Luis , De la Rubia Javier , Montesinos Pau , Martínez-Cuadrón David
Published: April 2022

Background: Information regarding the impact on healthcare systems of secondary acute myeloid leukemia (sAML) is scarce. Methods: A retrospective review of medical charts identified patients aged 60–75 years with sAML between 2010 and 2019. Patient information was collected from diagnosis to death or last follow-up. Outpatient resource use, reimbursement, frequency and duration of hospitalization, and transfusion burden were assessed. Forty-six patients with a median age of 64 years were included. Anthracycline plus cytarabine regimens were the most common induction treatment (39 patients, 85%). The ratio of the total days hospitalized between the total follow-up was 29%, with a sum of 204 hospitalizations (average four/patient; average duration 21 days). The total average reimbursement was EUR 90,008 per patient, with the majority (EUR 77,827) related to hospital admissions (EUR 17,403/hospitalization). Most hospitalizations (163, mean 22 days) occurred in the period before the first allogeneic hematopoietic stem cell transplant (alloHSCT), costing EUR 59,698 per patient and EUR 15,857 per hospitalization. The period after alloHSCT (in only 10 patients) had 41 hospitalizations (mean 21 days), and a mean reimbursement cost of EUR 99,542 per patient and EUR 24,278 per hospitalization. In conclusion, there is a high consumption of economic and healthcare resources in elderly patients with sAML receiving active treatments in Spain.