bluuebunny/crossref_metadata_2025 huggingface dataset:
Nystagmus in children with primary brain tumours in Denmark between 2007 and 2017
Authors: Rosenberg Jacqueline Gremaud , Nissen Kamilla , Heegaard Steffen , Ragunathan Suganiah , Schmiegelow Kjeld , Mathiasen René , von Holstein Sarah Linea
Published: October 2023

Background

The aim of the study was to evaluate the prevalence, clinical characteristics, and diagnostic importance of nystagmus in children with brain tumours.

Methods

A nation-wide retrospective review of all children diagnosed with a brain tumour between January the 1st, 2007 and December 31st, 2017, in Denmark. Data is based on information from the Danish Childhood Cancer Registry, hospital records from paediatric- and ophthalmological departments, and records from private ophthalmologists.

Results

Nystagmus was observed in 13.7% (60/437) of children with a brain tumour. In 50/60 children (83.3%) nystagmus was an incidental finding at the clinical examination and only in 10/60 children (16,7%) were nystagmus noticed by patient/caregivers prior to the clinical examination. In 38/60 children nystagmus was observed before the brain tumour diagnosis, most often (16/38, 42%) the same day as the diagnosis was made. In 22/60 children nystagmus was found after the brain tumour diagnosis (prior to any treatment) with a median of four days (range 0-47) after the brain tumour diagnosis. Nystagmus was most commonly binocular (56/60, 93.3%) and gaze-evoked (43/60, 71.7%). The median number of additional symptoms and/or clinical findings was five (range 0–11).

Conclusion

Nystagmus is frequent in children with brain tumours and is typically accompanied by other symptoms and clinical signs. However, nystagmus is often first recognized by the ophthalmologist late in the time course. Therefore, raising awareness of the importance of looking for nystagmus in children with unspecific neurological symptoms might contribute to increased suspicion of brain tumour and thereby faster diagnosis.
Management of functional outcomes after radical prostatectomy in the Nordic countries: A survey of uro-oncological centers
Authors: Nolsøe Alexander Bjørneboe , Holm Henriette Veiby , Murtola Teemu J. , Østergren Peter Busch , Fode Mikkel
Published: October 2023

We aimed to describe the clinical practice regarding erectile dysfunction and urinary incontinence after radical prostatectomy in the Nordic countries. A 37-item survey about pre- and post-prostatectomy evaluation and rehabilitation of sexual and urinary function was sent to 42 uro-oncology centers. Reporting was done according to the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Twenty-seven centers in Denmark (n = 6), Norway (n = 8), Finland (n = 7), and Sweden (n = 6) responded (64.3%). Post-prostatectomy sexual function was evaluated by 25 centers. The majority used validated questionnaires with significant variations across centers. Post-prostatectomy urinary function was evaluated by 24 centers. Again, the majority used validated questionnaires, while 9 centers used objective measures including uroflowmetry, residual urine volume, and pad usage. Twenty-one centers offered sexual rehabilitation and 12 of these described their protocols. All centers administered phosphodiesterase-5 inhibitors and seven centers offered further treatment options. Two centers offered a consultation with a sexologist. Twenty-three centers provided pelvic floor muscle training and one center used medical support with duloxetine. Our study indicates a need for standardized evaluation and management of erectile dysfunction and urinary incontinence following radical prostatectomy. Especially, there is a need for an increased focus on comprehensive sexual rehabilitation.
Natural killer cell activity in metastatic castration resistant prostate cancer patients treated with enzalutamide
Authors: Zedan A. H. , Nederby L. , Volmer L. M. , Madsen C. V. , Sørensen B. E. , Hansen T. F.
Published: October 2023

Metastatic castration resistant prostate cancer (mCRPC) is still the lethal stage for the whole spectrum of prostate cancer disease. Even though different treatment options have been introduced in the last decade with a significant survival improvement for this population, a lack of more reliable prognostic and predictive markers is still one of the main clinical challenges in management of mCRPC. The aim of this study was to investigate the correlation between Natural Killer cell activity (NKA) and both treatment effect and outcomes in patients with mCRPC treated with enzalutamide. A total of 87 patients with mCRPC treated with enzalutamide as the first line treatment were enrolled. NKA was estimated at baseline and prior to each treatment cycle. Endpoints included both treatment effect with biochemical response (BR), biochemical progression (BP) and radiological progression (RP), as well as outcome data with overall survival (OS), radiologic progression free survival (rPFS), and time to next treatment (TTT). At the time of BR, interferon-gamma (IFNγ) decreased significantly compared to levels detected at baseline (z-score = 2.33, p = 0.019). Regarding outcome data, the whole cohort was divided into four groups according to the change of IFNγ level during the first 3 cycles of enzalutamide treatment. In group 1 (n = 42) the IFNγ level remained within a normal range (≥ 250 pg/mL),while in group 2 (n = 7) it increased from an abnormal (< 250 pg/mL) to a normal level. In group 3 (n = 13) it dropped to an abnormal level, and it remained at an abnormal level during treatment in group 4 (n = 17). Patients in group 2 showed the worst prognosis with shorter both rPFS and TTT (HR 4.30, p = 0.037; and HR 6.82, p = 0.011, respectively). In this study inverse correlations between NKA and both treatment response and outcomes was observed in mCRPC patients receiving enzalutamide, suggesting an unfavourable role of NK cells in the late stage of PCa.
Shifts of the soil microbiome composition induced by plant–plant interactions under increasing cover crop densities and diversities
Authors: Newberger Derek R. , Minas Ioannis S. , Manter Daniel K. , Vivanco Jorge M.
Published: October 2023

Interspecific and intraspecific competition and facilitation have been a focus of study in plant-plant interactions, but their influence on plant recruitment of soil microbes is unknown. In this greenhouse microcosm experiment, three cover crops (alfalfa, brassica, and fescue) were grown alone, in paired mixtures, and all together under different densities. For all monoculture trials, total pot biomass increased as density increased. Monoculture plantings of brassica were associated with the bacteria Azospirillum spp., fescue with Ensifer adhaerens, and alfalfa with both bacterial taxa. In the polycultures of cover crops, for all plant mixtures, total above-ground alfalfa biomass increased with density, and total above ground brassica biomass remained unchanged. For each plant mixture, differential abundances highlighted bacterial taxa which had not been previously identified in monocultures. For instance, mixtures of all three plants showed an increase in abundance of Planctomyces sp. SH-PL14 and Sandaracinus amylolyticus which were not represented in the monocultures. Facilitation was best supported for the alfalfa-fescue interaction as the total above ground biomass was the highest of any mixture. Additionally, the bulk soil microbiome that correlated with increasing plant densities showed increases in plant growth-promoting rhizobacteria such as Achromobacter xylosoxidans, Stentotrophomonas spp., and Azospirillum sp. In contrast, Agrobacterium tumefaciens, a previously known generalist phytopathogen, also increased with alfalfa-fescue plant densities. This could suggest a strategy by which, after facilitation, a plant neighbor could culture a pathogen that could be more detrimental to the other.
Validation of an on-chip p16ink4a/Ki-67 dual immunostaining cervical cytology system using microfluidic device technology
Authors: Hashimoto Kei , Kumagai Tomoo , Nomura Kyosuke , Miyagawa Yuko , Tago Saori , Takasaki Kazuki , Takahashi Yuko , Nishida Haruka , Ichinose Takayuki , Hirano Mana , Hiraike Haruko , Wada-Hiraike Osamu , Sasajima Yuko , Kim Soo Hyeon , Nagasaka Kazunori
Published: October 2023

More specific screening systems for cervical cancer may become necessary as the human papillomavirus (HPV) vaccine becomes more widespread. Although p16/Ki-67 dual-staining cytology has several advantages, it requires advanced diagnostic skills. Here, we developed an automated on-chip immunostaining method using a microfluidic device. An electroactive microwell array (EMA) microfluidic device with patterned thin-film electrodes at the bottom of each microwell was used for single-cell capture by dielectrophoresis. Immunostaining and dual staining for p16/Ki-67 were performed on diagnosed liquid cytology samples using the EMA device. The numbers of p16/Ki-67 dual-stained cells captured by the EMA device were determined and compared among the cervical intraepithelial neoplasia (CIN) lesion samples. Seven normal, fifteen CIN grade 3, and seven CIN grade 2 samples were examined. The percentage of dual-positive cells was 18.6% in the CIN grade 2 samples and 23.6% in the CIN grade 3 samples. The percentages of dual-positive staining increased significantly as the severity of the cervical lesions increased. p16/Ki67 dual immunostaining using the EMA device is as sensitive as the conventional method of confirming the histopathological diagnosis of cervical samples. This system enables a quantified parallel analysis at the individual cell level.
Comparing gingivitis diagnoses by bleeding on probing (BOP) exclusively versus BOP combined with visual signs using large electronic dental records
Authors: Patel Jay S. , Shin Daniel , Willis Lisa , Zai Ahad , Kumar Krishna , Thyvalikakath Thankam P.
Published: October 2023

The major significance of the 2018 gingivitis classification criteria is utilizing a simple, objective, and reliable clinical sign, bleeding on probing score (BOP%), to diagnose gingivitis. However, studies report variations in gingivitis diagnoses with the potential to under- or over-estimating disease occurrence. This study determined the agreement between gingivitis diagnoses generated using the 2018 criteria (BOP%) versus diagnoses using BOP% and other gingival visual assessments. We conducted a retrospective study of 28,908 patients' electronic dental records (EDR) from January-2009 to December-2014, at the Indiana University School of Dentistry. Computational and natural language processing (NLP) approaches were developed to diagnose gingivitis cases from BOP% and retrieve diagnoses from clinical notes. Subsequently, we determined the agreement between BOP%-generated diagnoses and clinician-recorded diagnoses. A thirty-four percent agreement was present between BOP%-generated diagnoses and clinician-recorded diagnoses for disease status (no gingivitis/gingivitis) and a 9% agreement for the disease extent (localized/generalized gingivitis). The computational program and NLP performed excellently with 99.5% and 98% f-1 measures, respectively. Sixty-six percent of patients diagnosed with gingivitis were reclassified as having healthy gingiva based on the 2018 diagnostic classification. The results indicate potential challenges with clinicians adopting the new diagnostic criterion as they transition to using the BOP% alone and not considering the visual signs of inflammation. Periodic training and calibration could facilitate clinicians' and researchers' adoption of the 2018 diagnostic system. The informatics approaches developed could be utilized to automate diagnostic findings from EDR charting and clinical notes.
An ion-selective chemiresistive platform as demonstrated for the detection of nitrogen species in water
Authors: Darestani-Farahani Maryam , Ma Fanqing , Patel Vinay , Selvaganapathy Ponnambalam Ravi , Kruse Peter
Published: October 2023

Ion-selective chemiresistive sensor platform for continuous monitoring over a wide concentration range, with low LOD, good response time, selectivity, reproducibility, and reversibility. The economical, simple devices don't need reference electrodes.
Progress and future prospects of hemostatic materials based on nanostructured clay minerals
Authors: Yang Yinfeng , Wang Xiaomei , Yang Fangfang , Mu Bin , Wang Aiqin
Published: October 2023

The unique structures of CMs and various CMs-based hemostatic composites.
A triad molecular conductor: simultaneous control of charge and molecular arrangements
Authors: Kinoshita Naoya , Maruyama Atsuya , Shirahata Takashi , Naito Toshio , Misaki Yohji
Published: October 2023

Molecular and charge arrangements in the solid state were controlled by a new building block: a triad molecule.
Nitrogen-doped Fe7S8 as highly efficient electrocatalysts for the hydrogen evolution reaction
Authors: Ye Jian , Niu Shuwen , Zhang Leijie , Wang Gongming , Zhu Junfa
Published: October 2023

N-induced doping effect and phase transition engineering can downshift the unoccupied d orbitals and strengthen the interfacial orbital coupling to boost the water dissociation kinetics of FeS2.
Ultrafast charge transfer in metal-free H2O2 photoproduction by anhydride modified g-C3N4
Authors: Xie Ying , Liu Jingjing , Wang Guanxiong , Hu Qiushi , Chen Xihan
Published: October 2023

Ultrafast electron transfer is observed in g-BTDA enabled H2O2 photocatalysis, and a production of 22.5 μmol is achieved within 8 hours.
Electrochemiluminescence of dimethylaminonaphthalene-oxazaborine donor–acceptor luminophores
Authors: Kim Kyoung-Rok , Kim Jiwoo , Oh Jinrok , Kim Joohoon , Hong Jong-In
Published: October 2023

Dimethylaminonaphthalene-oxazaborine donor–acceptor molecules were developed as efficient electrochemiluminescent luminophores with tunable intramolecular charge transfer.
trans-Cleavage of the CRISPR-Cas12a-aptamer system for one-step antigen detection
Authors: Fan Hongxuan , Luo Shi-hua , Zhu Ying , Shi Jiye , Yin Fangfei , Li Jiang
Published: October 2023

A one-step, amplification-free detection strategy with high sensitivity for prostate-specific antigen is devised based on a CRISPR-Cas12a-Aptamer system.
NHC-catalyzed radical acylation of cycloalkyl silyl peroxides to access 1,6-,1,7-, and 1,8-diketones
Authors: Liu Chaolei , Wang Jingyi , Liu Xinlong , Feng Jie , Du Ding
Published: October 2023

An NHC organocatalytic radical acylation of cycloalkyl silyl peroxides with aldehydes was developed for the efficient and rapid synthesis of long-chain 1,6-/1,7-/1,8-diketones, especially unsymmetrical ones.
Complex role of chemical nature and tacticity in the adsorption free energy of carboxylic acid polymers at the oil–water interface: molecular dynamics simulations
Authors: Kurapati Raviteja , Natarajan Upendra
Published: October 2023

Effect of tacticity and hydrophobicity of carboxylic acid polymers on its free energy of adsorption at oil–water interface.
P-doped binary Ni/Fe–N–C for enhanced oxygen electrocatalysis performance
Authors: Jia Hongrui , Meng Xiangshe , Lin Yan , Wang Danni , Li Guoqiang , Zhang Guoxin
Published: October 2023

P-doped NiFe–NC exhibits favorable bifunctional oxygen electrocatalysis performance, rendering an EORR1/2 of 0.85 V and an EORRj10 of 1.69 V.
Fluoroborate ionic liquids as sodium battery electrolytes
Authors: Duncan Dale T. , Piper Samantha L. , Forsyth Maria , MacFarlane Douglas R. , Kar Mega
Published: October 2023

Fluoroborate ionic liquids have emerged as promising electrolyte materials for next-generation high-voltage sodium batteries.
Strongly emitting, centrosymmetric, ladder-type bis-coumarins with crankshaft architecture
Authors: Kumar G. Dinesh , Liao Yu-Chan , Nazir Rashid , Banasiewicz Marzena , Chou Pi-Tai , Gryko Daniel T.
Published: October 2023

Easily accessible, centrosymmetric, crankshaft-shaped bis-coumarins possess strongly bathochromically shifted emission.
Size dependence of optical nonlinearity for H-capped carbon chains, H–(CC)n–H (n = 3–15): analysis of its nature and prediction for long chains
Authors: Liu Zeyu , Wang Jiaojiao , Zhou Qing , Lu Tian , Wang Xia , Yan Xiufen , Zhao Mengdi , Yuan Aihua
Published: October 2023

The NLO properties of H-capped carbon chains have been theoretically studied for the first time, and two formulas for the size dependence of their (hyper)polarizabilities are obtained: αiso(∞) = −0.206 + 0.264n1.498 and γ‖(∞) = −0.624 + 0.006n3.368.
Synthesis, structure and characterization of Cd2TeO3Cl2 with unprecedented [Cd2O6Cl4] octahedral dimers
Authors: Wang Linan , Bai Chen , Kong Yingying , Iqbal Maqsood , Chu Yu , Li Junjie
Published: October 2023

A new mixed anionic compound Cd2TeO3Cl2 has been synthesized with CdCl2 as flux, which shows a mixed cationic layer structure constituted by distorted [TeO3], mixed anionic [Cd2O6Cl4] chains, and unprecedented [Cd2O6Cl4] octahedral dimers.
Dyes as efficient and reusable organocatalysts for the synthesis of cyclic carbonates from epoxides and CO2
Authors: Chen Jing , Chiarioni Giulia , Euverink Gert-Jan W. , Pescarmona Paolo P.
Published: October 2023

The functionalised RhB-EtOH-I dye was identified as an efficient and reusable organocatalyst for the conversion of CO2 and epoxides into cyclic carbonates under mild conditions.
Efficient lignin depolymerization by continuous flow microreactor-assisted electrochemical advanced oxidation in water/co-solvent system
Authors: Waura-angkura Lalida , Matsagar Babasaheb M. , Lee Kevin , Pavarajarn Varong , Wu Kevin C.-W.
Published: October 2023

The employment of EAOP using a continuous flow microreactor for efficient lignin depolymerization under ambient conditions.
Hot Pickering emulsion interfacial catalysis accelerates polyethylene terephthalate (PET) glycolysis
Authors: Chen Qinan , Wu Shuyao , Zhang Po , Song Xi-Ming , Song Zhining
Published: October 2023

A stable hot Pickering emulsion interfacial catalysis (HPEIC) system was constructed by a kind of asymmetric silica nanonets (M-ANNs). The system achieved 100% depolymerization of PET with a yield of PET monomer more than 90% within 5 min at 170 °C.
Guanidine-based protic ionic liquids as highly efficient intermolecular scissors for dissolving natural cellulose
Authors: Chen Shi-Peng , Zhu Jin-Long , Chen Xing-Ru , Wang Zhi-Hao , Dan Yong-Jie , Wang Jing , Zhou Sheng-Yang , Zhong Gan-Ji , Huang Hua-Dong , Li Zhong-Ming
Published: October 2023

Guanidine-based protic ionic liquids ([TMGH][MAA]) are designed as intermolecular scissors for efficiently dissolving cellulose by the synergistic interactions of the [TMGH] cations and [MAA] anions with the hydroxyl groups in the cellulose chains.
Highly conductive and porous lignin-derived carbon fibers
Authors: Jia Guosheng , Yu Yan , Wang Xuefen , Jia Chao , Hu Zexu , Yu Senlong , Xiang Hengxue , Zhu Meifang
Published: October 2023

The highly conductive and porous LCFs are developed through melt-blowing, pretreatment, and carbonization processes. The resultant LCFs exhibit high electrical conductivity (71 400 S m−1) and a large specific surface area (923 m2 g−1).
A high-performance dual-functional organic upconversion device with detectivity approaching 1013 Jones and photon-to-photon efficiency over 20%
Authors: He Zeyu , Zhang Heng-yuan , Du Xiaoyang , Yu Xin , Han Jiayue , Cao Luye , Lin Hui , Wang Jun , Zheng Caijun , Tao Silu
Published: October 2023

A high-performance dual-functional organic upconversion device with detectivity approaching 1013 Jones and photon-to-photon efficiency over 20% was realized and pulse-state testing and bio-imaging were realized with high-quality results.
A convenient and large-scale fabrication of ordered micron-sized porous polyimide film
Authors: Huo Mengwei , Guo Yi , Wang Xinbo
Published: October 2023

Ordered micron-sized macroporous PI films were fabricated using PAA-b-PS with a specific volume fraction of PS, in which the synergistic effect of hydrogen bonds and π–π interactions of the main chain in PAA-b-PS plays a pivotal role.
Sequential on–off–on detection of Fe2+ and enantiomeric l-lysine with logic gate operation based on fluorescent carbon dots derived from a zinc–amine complex
Authors: Zhang Xinlei , Liu Peng , Zhang Yuchi , Li Bohan , Xu Yan
Published: October 2023

[Zn(EDA)3]Cl2 derived carbon dots were prepared for continuous Fe2+ and l-lysine detection, molecular logic gate operation and cell imaging applications.
A macrocyclic fluorescent probe for the detection of citrate
Authors: Butler Stephen M. , Hountondji Maria , Berry Stuart N. , Tan Jian , Macia Laurence , Jolliffe Katrina A.
Published: October 2023

A macrocycle that contains multiple hydrogen bond donors provides a selective ‘turn-on’ fluorescence response upon binding to citrate in aqueous media.
Correction: Turn-on fluorogenic sensors based on an anthraquinone signaling unit for the detection of Zn(ii) and Cd(ii) ions
Authors: Kongsak Chawanakorn , Chiangraeng Natthiti , Rithchumpon Puracheth , Nimmanpipug Piyarat , Meepowpan Puttinan , Tuntulani Thawatchai , Thavornyutikarn Praput
Published: October 2023

Correction for ‘Turn-on fluorogenic sensors based on an anthraquinone signaling unit for the detection of Zn(ii) and Cd(ii) ions’ by Chawanakorn Kongsak et al., Org. Biomol. Chem., 2023, 21, 7367–7381, https://doi.org/10.1039/D3OB01223A.
Construction of the lactate-sensing fibremats by confining sensor fluorescent protein of lactate inside nanofibers of the poly(HPMA/DAMA)/ADH-nylon 6 core–shell fibremat
Authors: Kato Yuna , Iwata Shuichi , Nasu Yusuke , Obata Akiko , Nagata Kenji , Campbell Robert E. , Mizuno Toshihisa
Published: October 2023

New materials platform, capable of sustaining the functionality of proteinous sensor molecules over an extended period without being affected by proteases.
Multifunctional properties of D–A luminophores based on acenaphtopyrido[2,3-b]pyrazine core: photophysics, photochemistry, and efficient solution-processed OLEDs
Authors: Silva Welisson de Pontes , Decarli Nícolas Oliveira , Espíndola Leandro , Erfurt Karol , Blacha-Grzechnik Agata , Pander Piotr , Lapkowski Mieczyslaw , Data Przemyslaw
Published: October 2023

We present multifunctional donor–acceptor luminophores displaying TADF, RTP or AIE suitable for use as sensitisers for singlet oxygen generation as well as OLED emitters.
Enhanced sub-band gap photosensitivity by an asymmetric source–drain electrode low operating voltage oxide transistor
Authors: Pandey Utkarsh , Yadav Akhilesh Kumar , Pal Nila , Aich Pijush Kanti , Pal Bhola N.
Published: October 2023

The photosensitivity of a phototransistor can be enhanced by using an asymmetric work function source–drain (S–D) electrode.
Proton conduction of an ionic HOF with multiple water molecules and application as a membrane filler in direct methanol fuel cells
Authors: Zhao Fang , Cao Li-Hui , Ji Can
Published: October 2023

The proton conduction properties of iHOF-8 and its Nafion-based composite membrane were investigated and the results proved to be of potential value in DMFCs.
Prevalence of Presbyphonia in Older Adults With Dysphonia: A Systematic Review and Meta-Analysis
Authors: Chang Fei-Chun , Doan Thanh-Nhan , Wang Liang-Hui , To Thi-Lien , Ho Wen-Chao , Chou Li-Wei
Published: October 2023

Purpose:

This study aims to investigate the prevalence of presbyphonia among older adults who report voice complaints.

Method:

We conducted a systematic search of five medical databases to identify studies that reported on presbyphonia as the cause of voice disorders in older adults. The pooled prevalence was calculated using random-effects models and presented as percentages with 95% confidence intervals (CI). The degree of heterogeneity among studies was assessed using
I
2
statistics. Subgroup analyses were performed to identify the sources of heterogeneity.

Results:

Out of 764 abstracts from five libraries, 11 studies were included in this systematic review. The pooled prevalence of presbyphonia among older adults with voice disorders is 17.78% (95% CI [12.69, 23.51]). We conducted a subgroup analysis on studies that used laryngeal visualization to confirm the diagnosis for all patients and found that the prevalence of presbyphonia was lower in studies with unrestrictive inclusion criteria (12.84%, 95% CI [8.38, 18.08]) compared to studies with restricted inclusion criteria (22.59%, 95% CI [14.49, 31.88]).

Conclusions:

This study suggests that voice disorders in older adults have multiple causes, not predominantly presbyphonia. Overestimation of presbyphonia prevalence occurs if certain diagnoses are excluded at recruitment. This study emphasizes the importance of recognizing the diverse underlying etiologies of dysphonia in older adults; therefore, comprehensive examination and accurate diagnosis are crucial.

Supplemental Material:

https://doi.org/10.23641/asha.24263029
Views of Parents on Supporting Language and Literacy for Their Children With Complex Communication Needs
Authors: Leroux Emma L. , Biggs Elizabeth E. , Shin Doah E.
Published: October 2023

Purpose:

Understanding students' home literacy environments can help speech-language pathologists, teachers, and other educators partner with families to promote language and literacy learning. This study focused on gaining insight into the views of parents of elementary-age students with intellectual and developmental disabilities who had complex communication needs related to supporting children's language and literacy learning in the home.

Method:

This qualitative study was conducted during the COVID-19 pandemic, when many schools were utilizing remote or hybrid learning arrangements. Participants were 37 parents of students with complex communication needs in kindergarten to fourth grade. Most children had either autism or Down syndrome, and they ranged from primarily communicating prelinguistically (e.g., gestures and nonword vocalizations) to using some two to three word phrases in different modes (e.g., speech, sign, and aided augmentative and alternative communication [AAC]). Each parent was interviewed three times over the 2020–2021 school year, and data were analyzed using an inductive qualitative approach.

Results:

Findings showed patterns of commonalities and differences in parents' experiences, including related to their (a) goals and values about communication, language, and literacy; (b) perceptions and experiences with roles supporting language and literacy; and (c) satisfaction with supports and progress in these areas.

Conclusion:

This study provides important insight into the views of parents related to home literacy that can be used to improve the design and delivery of interventions for school-age students with complex communication needs and their families.
An effective fault tolerance aware scheduling using hybrid horse herd optimisation‐reptile search optimisation approach for a cloud computing environment
Authors: Malik Manoj Kumar , Joshi Hitesh , Swaroop Abhishek
Published: October 2023

IT services can be requested via cloud computing, a model based on services as well as the Internet. It includes all computer systems resources from hardware components to software platforms and software applications in a distributed environment. Scheduling is a key step in processing tasks using remote resources. Serious issues have been brought forward, including the ineffective use of resources and task execution failure. The concurrent provision of fault tolerance and resource optimisation is achallenging task. In the context of cloud computing, this research offers a brand‐new job scheduling and fault‐tolerant system. Tasks submitted by users are taken as an input for the proposed method. Several virtual machines (VM) are initially arranged for scheduling work and execution process. Initially, Horse Herd Optimisation is employed here to allocate the job based on key factors such as deadline and user budget. Once the jobs are assigned to each VM, then each job's deadline is confirmed and transferred to VM which has sufficient capacity. Here, the Reptile Search Optimisation technique is applied to identify the VM error. Any VM that does not have enough capacity is the one that has a problem. When a fault is found, a fault‐tolerant process is instantly started. A replication‐based fault‐tolerant mechanism is used in this manuscript. The proposed approach is tested with several metrics which attains better performance like 80 s response time, turnaround time of 32 s, 17% resource utilisation and a success rate of 92%. Thus the designed model is the best choice for fault‐tolerant aware task scheduling.
Density calculations of NGC 3783 warm absorbers using a time-dependent photoionisation model
Authors: Li Chen , Kaastra Jelle S. , Gu Liyi , Mehdipour Missagh
Published: October 2023

Outflowing wind, as one type of AGN feedback involving non-collimated ionised winds such as those prevalent in Seyfert-1 AGNs, impacts the host galaxy by carrying kinetic energy outwards. However, the distance of the outflowing wind is poorly constrained because of a lack of direct imaging observations, which limits our understanding of its kinetic power, and thus of its impact on the local galactic environment. One potential approach to solving this problem involves determination of the density of the ionised plasma, making it possible to derive the distance using the ionisation parameter ξ, which can be measured based on the ionisation state. Here, by applying a new time-dependent photoionisation model, tpho, in SPEX, we define a new approach, the tpho-delay method, which we use to calculate or predict a detectable density range for warm absorbers of NGC 3783. The tpho model solves self-consistently the time-dependent ionic concentrations, which enables us to study the delayed states of the plasma in detail. We show that it is crucial to model the non-equilibrium effects accurately for the delayed phase, where the non-equilibrium and equilibrium models diverge significantly. Finally, we calculate the crossing time to consider the effect of the transverse motion of the outflow on the intrinsic luminosity variation. Future spectroscopic observations with more sensitive instruments are expected to provide more accurate constraints on the outflow density, and therefore on the feedback energetics.
Selbsthilfemaßnahmen als Determinanten der Inanspruchnahme
einer Notfallambulanz bei Menschen mit und ohne Migrationsgeschichte in
Deutschland
Authors: Trümmler Jannis , Razum Oliver , Poetter Anna Rahel , Sauzet Odile
Published: October 2023

Einleitung Ziel der Untersuchung ist es zu analysieren, ob Unterschiede
zwischen Menschen mit und ohne Migrationsgeschichte in durchgeführten
Selbsthilfemaßnahmen vor einer Inanspruchnahme der Notaufnahme bestehen
und ob es Zusammenhänge zwischen Selbsthilfemaßnahmen und einer
adäquaten Inanspruchnahme der Notaufnahme gibt.

Methodik Datengrundlage für die sekundärbasierte Analyse
ist die EUMaR-Studie, die von Juli 2018 bis Juli 2019 durchgeführt
wurde, mit dem Ziel, Ursachen für die unangemessen häufige
Nutzung von Notfallambulanzen durch Migranten zu identifizieren. Ziel unserer
Studie ist es, Unterschiede der durchgeführten
Selbsthilfemaßnahmen und den Bevölkerungsgruppen anhand mehrerer
multiplen logistischer Regressionen zu analysieren. Der Zusammenhang zwischen
durchgeführten Selbsthilfemaßnahmen und adäquater
Nutzung der Notfallambulanz wird mit einer multiplen logistischen Regression und
anhand von Interaktionen quantifiziert.

Ergebnisse Migranten der ersten Generation weisen ein höheres Odds
Ratio auf, eine Notfallambulanz eigeninitiiert aufzusuchen (OR=1,28;
95% KI, 1,01–1,61), wie Menschen ohne Migrationsgeschichte.
Zudem weist diese Gruppe ein geringeres Odds Ratio auf, etwas gegen ihre
Beschwerden zu unternehmen (OR=0,70; 95% KI, 0,56–0,86).
Befragte, welche eigeninitiiert die Notfallambulanz aufsuchten, weisen ein
geringeres Odds Ratio bezüglich der adäquaten Nutzung der
Notfallambulanz auf (OR=0,41; 95% KI, 0,34–0,50).
Befragte, welche zuvor Vitalparameter (z. B. Blutdruck) gemessen haben,
haben ein höheres Odds Ratio, die Notfallambulanz adäquat zu
nutzen (OR=1,28; 95% KI, 1,02–1,59). Die erhaltenen
Schätzer durch die Interaktionsmodelle waren mit großen
Unsicherheiten verbunden.

Schlussfolgerung Zugangsbarrieren zum Gesundheitssystem, Medikamenten oder
zu medizinischen Hilfsmittelen bei Migranten der ersten Generation,
könnten das erhöhte Odds Ratio erklären, dass diese
Bevölkerungsgruppe vermehrt eigeninitiiert eine Notfallambulanz
aufsucht, sowie das geringere Odds Ratio, etwas gegen die Beschwerden zu
unternehmen. Eine Hypothese unserer Studie ist, dass die Messung der
Vitalparameter dazu beitragen kann, den individuellen Gesundheitszustand besser
zu beurteilen.
Natürliche Hautpflege mit ätherischen Ölen und Aromamischungen
Authors: Stadelmann Natalie
Published: October 2023

Die Haut ist das größte Organ des Menschen, deren Säureschutzmantel als Abwehrbarriere für äußere schädigende Einflüsse geschützt und unbedingt intakt gehalten werden muss. Dies kann mit einer biologischen Hautpflege aus naturreinen Zutaten und ohne unnötige Hilfs- und Konservierungsstoffe gelingen, da sie der Haut Lipide und Feuchtigkeit liefert. Die pflegetherapeutische Aromakultur (PTAK) dient der Pflege, der Gesunderhaltung und der Linderung von Beschwerden, auch als Begleitmaßnahme zu einer ärztlichen Therapie. Letztendlich profitiert jede Haut, sei es die sensible Baby- und Kinderhaut, die empfindliche, trockene oder neurodermitische Haut, die irritierte Teenagerhaut oder die anspruchsvolle reife Haut, von einer vernünftigen biologischen Aromapflege. Denn eine sinnvolle Hautpflege bedeutet aktive Stärkung der Eigenaktivität, Schutzbarriere und Balance der Haut statt passives „Zuschmieren“. Der Beitrag stellt die wichtigsten Stoffe und spezielle Anwendungsgebiete vor.
High Altitude
Authors: Berger Marc Moritz , Luks Andrew M.
Published: October 2023

With ascent to high altitude, barometric pressure declines, leading to a reduction in the partial pressure of oxygen at every point along the oxygen transport chain from the ambient air to tissue mitochondria. This leads, in turn, to a series of changes over varying time frames across multiple organ systems that serve to maintain tissue oxygen delivery at levels sufficient to prevent acute altitude illness and preserve cognitive and locomotor function. This review focuses primarily on the physiological adjustments and acclimatization processes that occur in the lungs of healthy individuals, including alterations in control of breathing, ventilation, gas exchange, lung mechanics and dynamics, and pulmonary vascular physiology. Because other organ systems, including the cardiovascular, hematologic and renal systems, contribute to acclimatization, the responses seen in these systems, as well as changes in common activities such as sleep and exercise, are also addressed. While the pattern of the responses highlighted in this review are similar across individuals, the magnitude of such responses often demonstrates significant interindividual variability which accounts for subsequent differences in tolerance of the low oxygen conditions in this environment.
Crystal Diseases of the Spine
Authors: Cotten Anne , Henry Simon , Scarciolla Laura , Abou Diwan Ralph , Demondion Xavier , Badr Sammy
Published: October 2023

Gout, calcium pyrophosphate deposition disease, and apatite calcifications, the three main crystal disorders, may involve the spine. These disorders can be completely asymptomatic or associated with various clinical symptoms, such as acute flares and more chronic manifestations. This article presents the typical and more unusual imaging features encountered in these disorders.
Congenital Intracranial Teratoma: Management Challenges!
Authors: Sarva Saiseema V. , Venkataraman Megha
Published: October 2023

Congenital brain tumors are extremely rare. Among them teratomas are the most common. They make up one-third of all congenital brain tumors. Late diagnosis, poor prognosis, and majority being delivered by cesarean section (subjecting the mother to increased morbidity) add to the complexities and challenges of the case. We report a rare case of a massive congenital brain tumor diagnosed prenatally on ultrasound. Because of the poor prognosis and associated craniomegaly, pregnancy termination was contemplated at 28 weeks aiming at vaginal delivery, despite a high probability of an eventual cesarean delivery due to the associated macrocrania. Intrapartum second stage of labor was protracted due to nondescent of the large head; however, providentially there was timely skull rupture of the fetus facilitating a vaginal delivery. The cerebral tumor was confirmed at autopsy to be an immature teratoma. There were no other associated malformations. Ultrasound has emerged as major modality in prenatal diagnosis aiding the antenatal preparation of the prospective parents and the multidisciplinary team for the poor outcome. The knowledge gained and anticipated prognosis help immensely in planning the management, thereby avoiding subjecting the woman to cesarean section and its morbidity.
Scoliosis
Authors: Lacroix Maxime , Khalifé Marc , Ferrero Emmanuelle , Clément Olivier , Nguyen Christelle , Feydy Antoine
Published: October 2023

Scoliosis is a three-dimensional spinal deformity that can occur at any age. It may be idiopathic or secondary in children, idiopathic and degenerative in adults. Management of patients with scoliosis is multidisciplinary, involving rheumatologists, radiologists, orthopaedic surgeons, and prosthetists. Imaging plays a central role in diagnosis, including the search for secondary causes, follow-up, and preoperative work-up if surgery is required. Evaluating scoliosis involves obtaining frontal and lateral full-spine radiographs in the standing position, with analysis of coronal and sagittal alignment. For adolescent idiopathic scoliosis, imaging follow-up is often required, accomplished using low-dose stereoradiography such as EOS imaging. For adult degenerative scoliosis, the crucial characteristic is rotatory subluxation, also well detected on radiographs. Magnetic resonance imaging is usually more informative than computed tomography for visualizing associated canal and foraminal stenoses. Radiologists must also have a thorough understanding of postoperative features and complications of scoliosis surgery because aspects can be misleading.
Current Role of Conventional Radiography of Sacroiliac Joints in Adults and Juveniles with Suspected Axial Spondyloarthritis: Opinion from the ESSR Arthritis and Pediatric Subcommittees
Authors: Sudoł-Szopińska Iwona , Herregods Nele , Zejden Anna , Jans Lennart , Giraudo Chiara , Boesen Mikael , Becce Fabio , Bazzocchi Alberto , Simoni Paolo , Aparisi Gómez Maria Pilar , Jaremko Jacob , Maas Mario , Teh James , Hermann Kay-Geert , Menegotto Flavia , Isaac Amanda , Reijnierse Monique , Shah Amit , Rennie Winston , Jurik Anne Grethe
Published: October 2023

This opinion article by the European Society of Musculoskeletal Radiology Arthritis and Pediatric Subcommittees discusses the current use of conventional radiography (CR) of the sacroiliac joints in adults and juveniles with suspected axial spondyloarthritis (axSpA). The strengths and limitations of CR compared with magnetic resonance imaging (MRI) and computed tomography (CT) are presented.

Based on the current literature and expert opinions, the subcommittees recognize the superior sensitivity of MRI to detect early sacroiliitis. In adults, supplementary pelvic radiography, low-dose CT, or synthetic CT may be needed to evaluate differential diagnoses. CR remains the method of choice to detect structural changes in patients with suspected late-stage axSpA or established disease and in patients with suspected concomitant hip or pubic symphysis involvement. In children, MRI is the imaging modality of choice because it can detect active as well as structural changes and is radiation free.
Patient, Caregiver, and Clinician Experience with a Technologically Enabled Pillbox: A Qualitative Study
Authors: Shannon Evan Michael , Mueller Stephanie K. , Schnipper Jeffrey L.
Published: October 2023

Objectives As part of a study to assess whether a technologically enabled pillbox prescribed to patients at hospital discharge can improve medication safety, we sought to assess participant experiences with the intervention.

Methods We conducted a series of semi-structured phone interviews with patients, patient caregivers, and inpatient and outpatient clinicians who participated in the Smart Pillbox Transition Study. We developed an interview guide using the Systems Engineering Initiative for Patient Safety (SEIPS) framework, which included the a priori domains of (1) barriers to implementation, (2) facilitators of the intervention, and (3) general feedback regarding experience with the intervention. Within these domains, we employed SEIPS-informed themes of environment and organization, logistics and tasks, personnel and patients, and technology and tools. Interviews were conducted between May 2018 and January 2019. We used content analysis to interpret findings.

Results We interviewed 6 patients, 2 caregivers, and 5 inpatient and 2 outpatient clinicians. Patient-endorsed barriers in the theme of technology and tools included signal issues, inappropriate alarms, and portability. Barriers in the theme of logistics and tasks included coordination with pharmacists in the event of a prescription change. Barriers mentioned by clinicians included patients who were poor fits for the intervention (theme: personnel and patients) and competing demands at discharge (theme: logistics and tasks). Facilitators that were frequently mentioned by patients and caregivers in the theme of technology and tools included useful alarms and ease of use. Clinicians stated that communication with pharmacy and study staff helped facilitate the intervention (theme: personnel and patients).

Conclusion We identified several key barriers and facilitators from patients, caregivers, and clinicians to successful implementation of this intervention. Reconciling these sometimes contrasting viewpoints will be crucial if the Smart Pillbox or similar health information technology interventions are to be adopted as tools to improve medication safety during care transitions.
Sustainable international business model innovations for a globalizing circular economy: a review and synthesis, integrative framework, and opportunities for future research
Authors: Chabowski Brian R. , Gabrielsson Peter , Hult G. Tomas M. , Morgeson Forrest V.
Published: October 2023

The global imperative has increased in recent years for international firms to respond to major threats such as unintended environmental, social, and economic problems arising from ecological destruction, population growth, and economic activity. To respond to this confluence that has created an emerging existential crisis, we identify that a globalizing circular economy (CE) is required and subsequently define a new construct: sustainable international business model innovations. In doing so, we introduce circular inputs, sharing platforms, product as a service, product use extension, and resource recovery as business models that contain the potential to reply to these grand challenges. Based on CE principles, the innovations and designs introduced are contrasted with the traditional linear economic model and are presented as actionable standardization/adaptation alternatives for companies responding to differing informal and formal international institutions. Based on the theoretical underpinnings of the resource-based, dynamic capabilities, and international business model innovation perspectives, we introduce an integrative framework that is accompanied by a series of detailed research questions to provide future research opportunities for the domain. This conceptual approach holds that international resource design influences marketing capabilities adaptation which, in turn, impacts international performance and offers a foundation from which to build the literature.
The role of carbon monoxide in the catalytic synthesis of endohedral carbyne
Authors: Mehmonov Kamoliddin , Ergasheva Aziza , Yusupov Maksudbek , Khalilov Umedjon
Published: October 2023

The unique physical properties of carbyne, a novel carbon nanostructure, have attracted considerable interest in modern nanotechnology. While carbyne synthesis has been accomplished successfully using diverse techniques, the underlying mechanisms governing the carbon monoxide-dependent catalytic synthesis of endohedral carbyne remain poorly understood. In this simulation-based study, we investigate the synthesis of endohedral carbyne from carbon and carbon monoxide radicals in the presence of a nickel catalyst inside double-walled carbon nanotubes with a (5,5)@(10,10) structure. The outcome of our investigation demonstrates that the incorporation of the carbon atom within the Nin@(5,5)@(10,10) model system initiates the formation of an elongated carbon chain. In contrast, upon the introduction of carbon monoxide radicals, the growth of the carbyne chain is inhibited as a result of the oxidation of endohedral nickel clusters by oxygen atoms after the initial steps of nucleation. Our findings align with prior theoretical, simulation, and experimental investigations, reinforcing their consistency and providing valuable insights into the synthesis of carbyne-based nanodevices that hold promising potential for future advancements in nanotechnology.
A co-simulation of superconducting qubit and control electronics for quantum computing
Authors: Jin Zhanhong , Li Shaowei , Wang Xinzhe , Liang Futian , Peng Cheng-Zhi
Published: October 2023

As the number of qubits in quantum computing increases, the scalability of existing qubit circuit structures and control systems may become insufficient for large-scale expansion and high-fidelity control. To address this challenge, we propose a behavioral-level model of a superconducting qubit and its control electronics, followed by a co-simulation to evaluate their performance. In this paper, we present the modeling process, simulation procedure, and resulting design specifications for the qubit control system. Our co-simulation approach utilizes MATLAB and Simulink, enabling us to derive critical circuit design specifications, such as the required Digital-to-Analog Converter (DAC) resolution, which should be 8 bits or higher, to achieve high-fidelity control. By taking into account factors such as DAC sampling rates, integral and differential nonlinearities, and filter characteristics, we optimize the control system for efficient and accurate qubit manipulation. Our model and simulation approach offer a promising solution to the scalability challenges in quantum computing, providing valuable insights for the design of large-scale superconducting quantum computing systems.
Mid-infrared modulated photoluminescence mapping to investigate in-plane distributions of bandedge transitions in As-doped HgCdTe
Authors: Chen Xiren , Wang Man , Zhu Liangqing , Xie Hao , Chen Lu , Shao Jun
Published: October 2023

In-plane distribution of band edge electronic structure of the narrow-gap arsenic (As)-doped HgCdTe is a crucial topic fundamentally and technically for mid-infrared detector array but hard to be investigated for long experimentally. This work reports a demonstration of the modulated photoluminescence (PL) mapping carried on As-doped HgCdTe, with the spatial resolution of a typical array pixel scale and with the elaborate band edge transitions being distinguished. Curve fittings related to the bandgap and to the impurities of Hg vacancy (VHg), As donor (AsHg), and AsHg–VHg pair are confirmed for PL mapping assisted by a temperature-dependent PL analysis. The spatial non-uniformity of Cd composition and the distributions of impurity relative concentrations are derived. Correlation analysis suggests that the As atom directly replacing the Hg atom in the complete lattice and the As atom occupying the already-existing VHg are the two approaches for the AsHg formation during As doping. The non-uniform band edge properties may lead to the in-plane conductivity fluctuation detrimental to the array performance. The results indicate the significance of probing the band edge impurity uniformity of As-doped HgCdTe for arrays fabrication, and the modulated PL mapping serving as a desirable and effective tool.