bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of studies on the formation of self-assessment of students in self-regulated learning using a metacognitive strategy (example of educational institutions of the People 's Republic of China)
Authors: Ли Н.
Published: June 2024

В начале XXI века все более широкое распространение стали получать такие теории обучения, как конструктивизм, метакогниция и cамообучение. Образовательное сообщество выступило за их внедрение в школах и высших учебных заведениях страны, обосновывая это тем, что данные процессы и методы обучения призывают обучающихся учиться учиться. Некоторые исследователи данных методик указали на нужность объединения процесса обучения с самооценкой обучающихся. В рамках развивающейся теории обучения и оценки самооценка делает акцент на повышении качества обучения обучающихся, что переводит формирование самооценки учеников из простой формы оценки в средство облегчения их обучения, суть которого заключается в направлении на саморегулируемое обучение учащихся. Для достижения целей качественного образования в Китае была проведена образовательная реформа, касающаяся, в частности, методик самооценки и саморегулируемого обучения. Основываясь на исследованиях самооценки обучающихся, проведенных китайскими и зарубежными исследователями, в данной статье обсуждается взаимосвязь между самооценкой и саморегуляцией обучения, метапознанием и самооценкой, чтобы прояснить исследовательскую природу самооценки обучающихся, которая может послужить некоторым источником вдохновения для научной реализации самооценки обучающегося.

At the beginning of the 21st century, with the continuous development of learning theories such as constructivism, metacognition and self-learning, the educational community began to pay attention to the processes and methods of teaching students, advocating that students learn to learn. Some assessment researchers have also further combined the learning process with student self-assessment. Within the framework of the developing theory of learning and assessment, self-assessment focuses on improving the quality of learning for students themselves, which translates the formation of students' self-assessmen from a simple form of assessment into a means of facilitating their learning, the essence of which is to direct the student to self-regulated learning. In order to achieve the goals of quality education in China, Chinese education has carried out comprehensive reform, in particular, the study of education assessment has become one of the focuses of research, in recent years, Chinese scientists have also conducted a number of studies on issues such as self-assessment and self-regulated learning. Based on studies of student self-assessment conducted by Chinese and foreign researchers, this article discusses the relationship between self-assessment and self-regulation of learning, metacognition and self-assessment in order to clarify the research nature of student self-assessment, which can serve as some source of inspiration for the scientific realization of student self-assessment.
WHY DO GAMERS PURCHASE VIRTUAL ITEMS IN MOBA GAMES?
Authors: Tuzzahra Andini Ginanti , Edastama Primasatria
Published: June 2024

This study explores and analyzes multiplayer online battle arena (MOBA) gamers’ motivation, experience and purchasing behavior in purchasing virtual items. A purposive sampling method was employed and there was a total of 469 respondents participated. The data was analyzed using structural equation modeling-partial least square (SEM-PLS) and partial least square-multigroup analysis (PLS-MGA). The results show that enjoyment, skill, challenge, telepresence, and interactivity have a positive impact on the flow. Further, the flow has a positive impact on both the purchase intention and continuous intention. In addition, both continuous intention and social value have a positive impact on the purchase intention. Lastly, the shopping enjoyment strengthens the positive impact of flow on both the continuous intention and purchase intention; and the positive impact of continuous intention on the purchase intention is strengthened by both shopping enjoyment and age. These findings highlight that there are many factors influencing the purchase intention of MOBA games’ virtual items, and provide a valuable contribution to practitioners and academics in relation to the factors influencing the MOBA gamers’ purchase of virtual items.JEL: M31.
Trends in Hyperlipidemia Treatments: Summary of Recommendations for Statin and Non-Statin Options
Authors:   Department of Family Medicine, The University of Toledo, USA, PA Schultz , P Chaudhri ,   Department of Family Medicine, The University of Toledo, USA, K Szymanski ,   Department of Family Medicine, The University of Toledo, USA, E Landis ,   Physician Assistant Studies – Dept of Family Medicine, The University of Toledo, USA, J Snyder ,   Physician Assistant Studies – Dept of Family Medicine, The University of Toledo, USA
Published: June 2024

Several treatment options and recommendations exist to guide a primary care provider to reduce overall cardiac morbidity and mortality risk through lipid control. The wealth of data from large studies, the choices of agents with varying mechanisms of action, and differing guidelines result in a challenge to keep abreast of this rapidly changing landscape. In this literature review the latest data regarding lipid management are reviewed and summarized. Current US and international cholesterol treatment guidelines recommend lifestyle modification followed by statin as first-line of therapy in management of hyperlipidemia. After optimizing statin dose if LDL remains above target goal, then the addition of ezetimibe provides added reductions in morbidity and mortality. Fibrates can be considered as an adjunct to statins therapy particularly in the diabetic population with persistent triglyceride elevations and provide modest reductions in coronary artery disease. PCSK9 inhibitors can reduce morbidity and mortality in a high-risk population when a statin or statin+ezetimibe does not bring LDL below the target goal. Some newer agents (ANGPTL3/ACL/MTP Inhibitors) are reserved for patients with a predisposition to ASCVD due to a familial genetic dyslipidemia. Cost for these adjunctive therapies is a concern for the patient and clinician and patient education along with a shared decision approach are warranted. To date, evidence for these agents is limited. Finally, there remains unclear guidance on the value between a “treat to dose” versus a “treat to target” approach to lipid management. Further research is needed to provide clarity on which strategy proves optimal for primary prevention of MACEs.
Exploring the Relationship between Pain, Psychiatric Factors, and Quality of Life in Patients with Complex Regional Pain Syndrome Type 1 after Distal Radius Fracture: An Observational, Descriptive, Cross-Sectional Study
Authors:   Musculoskeletal Pain and Motor Control Research Group, Faculty of Health Sciences, Universidad Europea de Canarias, 38300 Santa Cruz de Tenerife, Spain, Pérez Sebastián Eustaquio Martín , Marichal Jorge Hernández ,   Musculoskeletal Pain and Motor Control Research Group, Faculty of Health Sciences, Universidad Europea de Canarias, 38300 Santa Cruz de Tenerife, Spain, Puente Sergio Martínez ,   Musculoskeletal Pain and Motor Control Research Group, Faculty of Health Sciences, Universidad Europea de Canarias, 38300 Santa Cruz de Tenerife, Spain, Zaldívar Ignacio Suárez Solo de ,   Musculoskeletal Pain and Motor Control Research Group, Faculty of Health Sciences, Universidad Europea de Canarias, 38300 Santa Cruz de Tenerife, Spain, Pérez Isidro Miguel Martín ,   Departamento de Medicina Fisica y Farmacologia, Area de Radiologia y Medicina Fisica, Facultad de Ciencias de la Salud, Universidad de la Laguna, 38200, Santa Cruz de Tenerife, Espana
Published: June 2024

Introduction: Complex Regional Pain Syndrome type 1 (CRPS-1) is defined as a group of sensory and motor disorders that occur as a result of traumatic tissue damage, such as fractures of the distal radius. Pain persistence induces supramedullary neuroplastic changes, resulting in a central sensitization syndrome, in which psychological, affective, and behavioral dimensions interact to amplify the experience of pain. The primary objective of this study was to quantify the relationship between the intensity and duration of perceived pain and psychological factors and quality of life in CS patients diagnosed with CRPS-1 after distal radius fracture.
Equimolar Cross-Coupling Using Reactive Coiled Coils for Stable Covalent Protein Assemblies
Authors: Takeuchi Hironori , Shimshoni Elee , Gandhesiri Satish , Loas Andrei , Pentelute Bradley L.
Published: June 2024

Biocompatible cross-coupling reactions enable the efficient covalent attachment of large biomolecules at near-stoichiometric ratios, ensuring the stability and integrity of the resulting products. We present an affinity-based peptide platform utilizing coiled coils containing reactive side chains for proximity-driven protein cross-coupling in the presence of a cross-linking agent. This platform supports both chemical synthesis and recombinant expression, using canonical amino acids to generate reactive affinity tags. Employing the E3/K3 coiled coil pair as a scaffold, we design four complementary coils with cysteine residues as cross-linking sites, achieving >90% conversion to stable, covalent heterodimeric coupling products using 3,4-dibromomaleimide. Equimolar mixtures of proteins with reactive coils at their termini yield near-quantitative heterodimeric cross-coupling products. The strategic selection of complementary coiled coil pairs and cross-linking agents enables orthogonal assembly of macromolecules with diverse architectures. This method offers a versatile approach for creating covalent, stable fusion proteins, enhancing their stability and functionality for applications in chemical biology, biotechnology, and medicine.
Pyridinium-based fluorosulfonamide reagents enabled photoredox catalyzed radical fluorosulfonamidation
Authors: Wang Yi , Li Heyin , Zhang Xian , Wang Zhen , Sun Chao , Huang Mengjun , Liu Jing , Li Yifan , Zou Zhenlei , Pan Yi , Zhang Weigang
Published: June 2024

Sulfamoyl fluorides, as a crucial building block of SuFEx, have garnered extensive research interest due to their applications in chemical biology, materials science, and drug discovery. Recently, considerable research has been dedicated to the synthesis of sulfamoyl fluorides. However, the direct radical fluorosulfonamidation process for the synthesis of sulfamoyl fluorides employing fluorosulfonamide radicals has largely been overlooked. We herein disclosed a practical procedure for constructing bench-stable redox-active fluorosulfonamide radical reagent from inexpensive SO2F2, which would provide appropriate solution to the long-standing issue of radical fluorosulfonamidation. Simultaneously, the radical fluorosulfonamidating reagents, namely fluorosulfonyl-N-pyridinium tetrafluoroborate (PNSF), can be readily scaled up and prepared under simple aerobic conditions. These practical and air-stable crystalline salts can effectively facilitate a range of reactions, including the N-(fluorosulfonyl) sulfonamidation of diverse (hetero)arenes, sequential radical stereoselective fluorosulfonamidation, and the 1,2-difunctionalization of various alkenes, enabling the construction of a diverse array of functionalized sulfamoyl fluoride compounds.
Clinical studies of the human microbiome. Strategies for applying methods and translating results into clinical practice: A review
Authors: Koshechkin Stanislav I. , Odintsova Vera E. , Karasev Alexander V. , Zakharova Irina N. , Berezhnaya Irina V. , Kuchina Anastasiya E. , Yudina Anastasiya E. , Kuznetsova Irina S. , Dmitrieva Diana K. , Orobinskaya Yana V. , Serikova Liudmila S. , Makhaeva Anastasia V. , Romanov Vladimir A.
Published: June 2024

Current omics methods, which are essential for scientific research, are overviewed. These methods enable studies of the mechanisms of clinical manifestations by analyzing the relationship between the microbiota characteristics and clinical parameters. To represent the complex interactions between the microbiome and host metabolism, metagenomics and metabolomics techniques that contribute to the search for new therapeutic approaches are most relevant. Based on the metagenomic data, the associated taxa are searched, and the metabolic profile indicates the result of the activity of the microbial community. The characteristics of technologies for studying metagenomes using the amplicon sequencing method are considered, and the depth of identification of microorganisms, the level of sequencing errors and the preference in terms of cost are evaluated. Studying the evolution of pathogens and metabolic processes, expressed genes, and determinants of antibiotic resistance contributes to the development of rational strategies for disease therapy and control of the spread of infectious diseases. In recent years, the number of scientific projects in the field of microbiota research has been steadily increasing, which necessitates the need to raise physicians' awareness of modern methods and research approaches in order to apply relevant data in practical work.
Detection of slow slip events along the southern Peru - northern Chile subduction zone
Authors: Jara Jorge , Jolivet Romain , Socquet Anne , Comte Diana , Norabuena Edmundo
Published: June 2024

Detections of slow slip events (SSEs) are now common along most plate boundary fault systems at the global scale. However, no such event has been described in the south Peru - north Chile subduction zone so far, except for the early preparatory phase of the 2014 Iquique earthquake. We use geodetic template matching on GNSS-derived time series of surface motion in Northern Chile to extract SSEs hidden within the geodetic noise. We detect 33 events with durations ranging from 9 to 40 days and magnitudes from Mw 5.6 to 6.2. The moment released by these aseismic events seems to scale with the cube of their duration, suggesting a dynamic comparable to that of earthquakes. We compare the distribution of SSEs with the distribution of coupling along the megathrust derived using Bayesian inference on GNSS- and InSAR-derived interseismic velocities. From this comparison, we obtain that most SSEs occur in regions of intermediate coupling where the megathrust transitions from locked to creeping or where geometrical complexities of the interplate region have been proposed. We finally discuss the potential role of fluids as a triggering mechanism for SSEs in the area.
Unlocking rural entrepreneurship access to microfinance services in Zimbabwe- the moderating role of business performance
Authors: Leonard Mbira
Published: June 2024

Informed by the huge financed gap for Micro, small and medium enterprises (MSMEs, this study aims to identify the extent of intensity and significance of constraints to rural Micro, Small and Medium Enterprises (MSMEs) in accessing funding from microfinance institutions in Zimbabwe. The paper further explores potential avenues of unlocking rural MSME access to microfinancing. This study uses path modelling to investigate key demand side obstacles by rural MSMEs in accessing microfinance funding in the rural Matabeleland region of Zimbabwe and adopts a questionnaire based survey design targeting 301 rural micro entrepreneurs. The study shows that financial skills and knowledge, access to markets and technical skills are the main impediments to rural entrepreneurial access to microfinancing, however these predictors have more influence on rural entrepreneurial access to microfinancing when mediated by business performance. For successful sustainable poverty alleviation and employment creation for the bottom of the pyramid leveraging on a vibrant rural MSME sector, there is need for direct policy interventions to advance the financial literacy, financial management and technical skills for rural MSMEs as well as mechanisms to assist the MSMEs in securing markets. This paper makes significant contributions to the discourse of rural microenterprise financing debate by identifying significant constraints.
Impact of NEP 2020 on Tourism Sector of M.P. through Higher Education Programmes
Authors: Kirti Diddi  , Devyani Pandya
Published: June 2024

The National Education Policy (NEP) of India launched in 2020 has generated significant discussions on the changes needed in the higher education system of the country with an aim to transform India into a knowledge based economy , NEP proposes several reforms in the education sector including changes in curriculum pedagogy and assessment methods. One important aspects of any NEP is its potential impact on various industries particularly tourism sector and if the things are recollected then it’s experience is based on previous education policies, the focus of higher education was more on creating knowledge societies, thereafter stress shifted on balancing the knowledge content with real life requirement of skills to make the students of higher education system more employable as skill development and education is the need of the hour. In NEP 2020 various strategies are also mentioned for proper implementation of tourism education by way of enhancing collaboration with industry, internship program, inculcate major skills, develop technology within curriculum and many more but there are various issues in implementing NEP. This paper focuses on understanding the implementation of NEP in the context of tourism education and vocational education in tourism sector specifically and skill based vocational education in general in the higher education system of India through quantitative research methods. This research provides valuable insights for stakeholders in the higher education and tourism sectors on the impact of NEP implementation on the tourism industry in M.P.
Contribution of Evangelical Lutheran Church-Northen Diocese on the performance of community banks in Tanzania: A case of Uchumi Commercial Banks
Authors: Prosper J Kimaro
Published: June 2024

This study assessed the contribution of Evangelical Lutheran Church-Northern Diocese in Tanzania on the financial performance of Uchumi Commercial Bank. A specific focus was on how church-owned savings, loans and share capital affect community bank performance. Panel regression data analysis collected between 2016 and 2022 were employed. Bank performance measured in return on assets and return on capital (ROA & ROE respectively), Loan to Deposit Ratio (LDR) and share capital (SC). The findings show that the frequency of savings and loans provided to parishes, loan repayments and number of shares owned by parishes significantly influenced bank’s financial performance (p>0.05). The study recommends that Uchumi Commercial Bank should continue influencing non-church members’ to become members hence increasing the performance of the bank in terms of shares, capital and membership.
Effects of entrepreneurship education on entrepreneurial intention of the final year students of the Federal University Dutsin-Ma, Nigeria
Authors: Ahmadu Abubakar  , Nurudeen Yusuff  , Amina Ibrahim
Published: June 2024

This study examines the effect of entrepreneurship education on the entrepreneurial intention of 375 final year students of Federal University Dutsin-Ma (FUDMA), Nigeria. The study adopts a cross-sectional survey research design, and the structured questionnaire as a method of data collection. The study utilized both descriptive statistics such as frequencies and percentages, and the multiple regression techniques. The main findings indicate that attitude towards behaviour has no statistically significant effect on entrepreneurial intention; subjective social norm has a positive and significant effect on entrepreneurial intention, and perceived behaviour control has a significant and positive effect on entrepreneurial intention of the final students of the FUDMA. The study concludes that entrepreneurial intention of the FUDMA students is strongly influenced by the combination of the graduate’s personal inclination (i.e., interest, knowledge, ability, and self-confidence) and motivation from the family, relatives, friends, and known successful entrepreneurs. It is recommended that the Nigerian Universities Commission (NUC) should continue to ensure and enforced vigorously the compulsory teaching of entrepreneurship, which focused shall be on practical skills acquisition aimed at training students to be self-reliant. It is also recommended that university graduates should be encouraged by all and sundry in the society to be self-reliant and become employers of labour, rather than, the over-reliance on jobs from the public and private sectors, which are hardly available.
Characteristic and storage stability of nanostructured lipid carriers containing
red palm oil
Authors: Efendi Z. , Ardhi A. , Santoso U. , Supriyadi  , Ulfah M. , Raharjo S.
Published: June 2024

Red palm oil (RPO) is a potential carotenoid source mostly containing β-carotene. RPO
instability requires a delivery system such as nanostructured lipid carriers (NLC). This
research aimed to develop an NLC delivery system and study the characteristics of NLCRPO. The melting-emulsification-ultrasonication method was employed to produce the
NLC-RPO based on 6% (w/w) lipids, with solid lipid to RPO ratio (SRR) varied 6:4, 7:3,
and 8:2. Tween 80 (24% w/w) to lipids ratio of 4:1, and distilled water 70% (w/w). The
solid lipids employed in this investigation were palm stearin (PS), and palm kernel stearin
(PKS), while the liquid lipid was RPO. The stability of NLC-RPO was evaluated using βcarotene entrapment efficiency (EE), centrifugation, cooling, heating test, color, and pH
for 90 days of storage. The NLC-RPO was characterized by particle size, polydispersity
index (PDI), zeta potential, and viscosity before and after 90 days. Regression analysis
was performed to evaluate the relationships between the storage and stability parameters.
The highest encapsulation efficiency of β-carotene in NLC-RPO as a carrier β-carotene
from the RPO was achieved when solid lipid to RPO ratio (SRR) of 6:4 and there was no
significant difference in the type of solid lipid (PS and PKS) used. Generally, NLC-RPO
stored for 90 days at room temperature showed good stability after centrifugation, cooling
and heating tests with greenish-yellow color (-a*;+b*), and pH of 6.38-6.54. The particle
size (38-87 nm), PDI (0.01-0.54), and zeta potential (-10.17 to -22.67 mV) did not
significantly change over 90 days of storage, while the viscosity (8.36-9.11cP) was
significantly different. The NLC-RPO with SRR of 6:4 had the highest β-carotene
entrapment efficiency and remained stable after 90 days of storage at room temperature.
Fast food consumption, obesity and nutrient intake among adults in Indonesia
Authors: Andriyani A. , Lee Y.Z. , Win K.K. , Tan C.K. , Amini F. , Tan E.S.S. , Thiagarajah S. , Ng E.S.C. , Ahmad Bustami N.
Published: June 2024

Asian countries, including Indonesia, have experienced a significant shift in their diet with
increased fast food consumption spurred by rapid economic expansion, urbanisation and
social changes. Increasing mortality and morbidity following obesity and
noncommunicable diseases have been linked to an imbalanced nutrient intake. This study
assessed the pattern of fast food consumption with overweight, obesity and nutrient intake
of Indonesian adults. Three hundred eighty-five participants were conveniently recruited;
completed a questionnaire encompassing socio-demographics, the pattern of fast food
consumption and nutritional status. Also, participants’ anthropometric measurements were
obtained. Some participants were overweight (27.5%) and obese (8.6%). Fast food was
widely consumed by both genders; males (95%) and females (98%). Fast food
consumption rate was significantly associated (p<0.01) with marital status, education level
and monthly income. Married individuals (54%), those with post-graduate education
(68%), and higher-income earners (62%) consumed more fast food when eating out. There
was no significant association between fast food consumption rate and anthropometric
parameters, including obesity. However, fast food consumption rate, number of daily
meals replaced with fast food was significantly associated (p<0.05) with increased calorie
intake and fat intake. This growing tendency of energy-dense food consumption may
increase the risk of obesity in the long run, putting people at risk for various
noncommunicable diseases. The prevalence of overweight and obesity may be reduced by
promoting an active lifestyle, creating a supportive environment for voluntary physical
activity and restricting high-energy food consumption.
Analysis of Physics Concepts in Playgrounds at GoFun Bojonegoro as Learning Materials for Students
Authors: Mustafarah Vinka Amalia , Christi Alfiah Lina , Dwikoranto Dwikoranto , Ainur Rizki Iqbal
Published: June 2024

Objective: GoFun Bojonegoro is one of the area edutainments in Bojonegoro which has rides for games and entertainment with an attractive appeal for visitors. This study aims to analyse the physics concepts that exist in several game rides in GoFun Bojonegoro Theme Park. Some of the rides available at the park have interesting physics concepts to learn. Method: This type of research is descriptive qualitative research with observation, documentation, and analysis methods as a form of data collection. Results: There are three vehicles analysed namely, Pirates Ship, Mini Ontang-Anting, and Bom-Bom Car, which works based on the concept of physics. There are various physics concepts in the vehicle, such as the concept of oscillation, centrifugal force, circular motion, Newton's third law, collision, and the law of conservation of momentum and impulse. By integrating physics learning in the vehicle or edutainment make learning more fun. Novelty: This research provides edutainment-based learning that can increase the effectiveness of students in learning physics concepts and make students more active and learning looks fun.
Local Wisdom Oriented-Problem Based Learning Model Assisted by Interactive E-Magazine to Improve Students’ Critical Thinking Skills
Authors: Safitri Dwi , Inayah Nailil , Taufik Taufik , Astuti Julia
Published: June 2024

Objective: The aim of this investigation is to study and describe a Problem-Based Learning (PBL) model based on local wisdom assisted by interactive magazines to enhance students' critical thinking skills. Method: This study used a quasi-experimental design with a saturated sample technique. The tools employed were observation sheets monitoring both teacher and student activities, critical thinking tests, and a questionnaire. Results: Based on observations results, it was found that teacher and student activities were very good with percentages of 96,64% and 91,96% respectively. According to the t-test, the significance (two-tailed) value was 0.000, which is less than 0.05, leading to the rejection of the null hypothesis (H0). Therefore, it can be inferred that students' critical thinking skills differ significantly between the experimental and control classes. The category of critical thinking skills was less initially and improved into a critical category after the implementation of local wisdom-oriented problem-based learning assisted by an interactive e-magazine. Moreover, Learning using interactive magazines was also interesting, effective, and practical for students. Novelty: This research specifies the problem given to material or issues related to local wisdom of Malaysia for Indonesian students. Besides, the implementation of the model is assisted by the interactive media to strengthen the effects.
Pengaruh Ekstrak Daun Turi Merah (Sesbania grandiflora L.) terhadap Nilai Hematologi pada Mencit Jantan Diabetes
Authors: Dzannastia Aulya , Kuswanti Nur , Purnama Erlix Rakhmad
Published: June 2024

Diabetes melitus dapat mempengaruhi nilai hematologi darah, seperti kadar hemoglobin dan jumlah trombosit. Daun turi merah (Sesbania grandiflora L.) mengandung senyawa yang berpontensi untuk pengobatan diabetes dan perbaikan nilai hematologi. Tujuan penelitian ini ialah untuk mengetahui pengaruh ekstrak daun turi merah terhadap kadar hemoglobin dan jumlah trombosit pada mencit jantan diabetes, serta memperoleh dosis optimum. Penelitian dilakukan di Laboratorium Hewan Coba UNESA. Mencit diabetes dibuat dengan induksi aloksan 130 mg/kgBB. Penelitian menggunakan RAL dengan enam kelompok perlakuan yaitu kontrol negatif (KN), kontrol positif (KP), kelompok glibenclamide (KG), dan ekstrak (K1=250 mg/kgBB, K2=400 mg/kgBB, dan K3=500 mg/kgBB), masing-maisng dengan pengulangan sebanyak empat kali serta perlakuan selama 14 hari. Kadar hemoglobin diukur menggunakan strip test hemoglobin dan jumlah trombosit menggunakan metode Brecher Cronkite. Data dianalisis menggunakan uji normalitas, uji homogenitas, One-Way Anova, uji Duncan, dan uji Tukey. Hasil analisis menunjukkan ekstrak daun turi merah berpengaruh terhadap kadar hemoglobin (p<0,05) dan jumlah trombosit (p<0,05). Berdasarkan hasil penelitian disimpulkan bahwa ekstrak daun turi berpengaruh terhadap kadar hemoglobin dan jumlah trombosit mencit diabetes dengan 400 mg/kgBB estrak sebagai dosis optimum.
Pengaruh Penambahan Ekstrak Bawang Putih terhadap Pertumbuhan Fungi Aspergillus niger pada Media Murashige dan Skoog
Authors: Rafsanjani Muchammad Akbar , Trimulyono Guntur
Published: June 2024

Kultur jaringan adalah salah satu metode perbanyakan tanaman yang cukup sering digunakan. Namun, praktik kultur jaringan dapat digagalkan oleh kontaminasi fungi, salah satunya Aspergillus niger. Tujuan dari penelitian ini ialah untuk mengetahui kemampuan ekstrak bawang putih (Allium sativum) sebagai penghambat pertumbuhan jamur Aspergillus niger pada media Murashige & Skoog sebagai media kultur jaringan. Penelitian ini menggunakan Rancangan Acak Lengkap dengan satu faktor perlakuan berupa konsentrasi ekstrak bawang putih dengan 3 kali pengulangan. Uji aktivitas antifungi dilaksanakan menggunakan metode dilusi padat. Konsentrasi ekstrak bawang putih yang digunakan adalah 25%, 50%, dan 75%. Kontrol negatif berupa 1 ml DMSO 10%, sedangkan kontrol positif berupa 1 ml etanol 96% Pengamatan dilakukan pada hari ke 7 masa inkubasi yang dilakukan pada suhu ruang. Parameter yang diamati adalah hambatan pertumbuhan fungi yang terlihat dari pertumbuhan diameter koloni. Hasil yang diperoleh menunjukkan bahwa peningkatan konsentrasi berakibat pada peningkatan persentase daya hambat dan mengecilnya rata-rata diameter koloni. Konsentrasi 75% adalah konsentrasi yang paling efektif dalam menghambat pertumbuhan koloni Aspergillus niger dengan persentase daya hambat sebesar 56,59% dan diameter koloni sebesar 20,33 ± 0,76 mm. Dari hasil yang telah diperoleh, dapat disimpulkan bahwa ekstrak bawang putih mampu menghambat pertumbuhan jamur Aspergillus niger pada media Murashige & Skoog.
Isolasi Bakteri Endofit Akar Tanaman Bawang Merah (Allium cepa L.) sebagai Penghasil Hormon Indole-3-Acetic Acid (IAA)
Authors: Nofiyanti Safinatus Sabrina , Rahayu Yuni  Sri
Published: June 2024

Penelitian untuk mengisolasi bakteri endofit penghasil IAA dari berbagai tanaman diperlukan karena tanaman yang berbeda dapat menunjukkan jenis dan kemampuan bakteri endofit dalam menghasilkan IAA yang berbeda pula. Tanaman bawang merah merupakan komoditas yang membutuhkan peningkatan produktivitas karena jumlahnya masih kurang jika dibandingkan dengan jumlah konsumsinya. Oleh karena itu, tujuan penelitian ini adalah untuk mengisolasi dan mengkarakterisasi bakteri endofit pada akar tanaman bawang merah (Allium cepa L.), serta mengetahui kemampuannya dalam menghasilkan hormon IAA secara kualitatif dan kuantitatif. Kegiatan penelitian ini terdiri atas: isolasi; karakterisasi morfologi koloni, sifat gram, bentuk sel dan susunan sel; serta pengujian kemampuan bakteri menghasilkan IAA secara kualitatif menggunakan metode Salkowski dan secara kuantitatif menggunakan metode spektrofotometri. Berdasarkan hasil penelitian, dapat ditemukan dua belas isolat bakteri, antara lain isolat A61, A62, A63, A51, B61, B51, B52, B53, C51, C52, C53, dan C61. Hasil penelitian menunjukkan seluruh isolat mampu menghasilkan hormon IAA dengan rata-rata konsentrasi sebesar 15,180 ppm (A63); 13,256 ppm (A62); 10,228 ppm (A51); 9,952 ppm (B51); 9,241 ppm (B61); 8,662  ppm (C51); 7,326 ppm (B52); 6,703 ppm (C52); 6,272 ppm (C61); 6,158 ppm (A61); 6,005 ppm (C53); dan 5,018 ppm (B53). Isolat bakteri endofit akar bawang merah mampu menghasilkan IAA secara optimal pada hari ketiga inkubasi, yaitu berkisar antara 6,006 - 23,391 ppm. Isolat bakteri endofit dengan konsentrasi tertinggi (A63) berpotensi untuk dimanfaatkan sebagai pemacu pertumbuhan tanaman bawang merah, sehingga produktivitasnya juga berpotensi untuk mengalami peningkatan.
Fitoremediasi Fosfat dari Detergen Sintetis dengan Menggunakan Lemna minor dan Azolla microphylla
Authors: Silviana Lailatus , Rachmadiarti Fida
Published: June 2024

Limbah detergen merupakan salah satu penyebab pencemaran perairan. Salah satu bahan pembentuk detergen adalah Fosfat. Fosfat yang berlebihan di perairan menyebabkan eutrofikasi dan membahayakan biota air. Salah satu solusi untuk menurunkan kadar fosfat di perairan adalah memanfaatkan tumbuhan Lemna minor dan Azolla microphylla sebagai fitoremediator. Penelitian ini bertujuan untuk mengetahui pengaruh jenis tumbuhan dan konsentrasi detergen terhadap kadar fosfat pada media tanam. Penelitian ini merupakan penelitian eksperimental yang menggunakan Rancangan Acak Kelompok (RAK) dengan dua faktor perlakuan yaitu jenis tumbuhan Lemna minor dan Azolla microphylla dan konsentrasi detergen 10 ppm dan 20 ppm. Parameter yang diuji meliputi fosfat, suhu, pH, DO, BOD dan kadar klorofil daun. Analisis data dilakukan menggunakan ANAVA dua arah dilanjutkan dengan uji Duncan untuk mengetahui hubungan jenis tumbuhan dan konsentrasi terhadap penurunan kadar fosfat. Hasil penelitian menunjukkan bahwa jenis tumbuhan berpengaruh terhadap penurunan kadar fosfat. Penurunan kadar fosfat tertinggi terjadi pada tumbuhan Azolla microphylla pada konsentrasi 20 ppm sebesar 79,54% dan penurunan terendah terjadi pada tumbuhan Lemna minor pada konsentrasi 20 ppm dengan penurunan 55%. Kadar klorofil terendah pada fitoremediasi tumbuhan Lemna minor pada konsentrasi 10 ppm yaitu 5,74 mg/L sedangkan kadar klorofil tertinggi pada fitoremediasi tumbuhan Azolla microphylla pada konsentrasi 20 ppm yaitu 11,77 mg/L.
Efektivitas Ekstrak Daun Lamtoro (Leucaena leucocephala), Daun Pepaya (Carica papaya) dan Kombinasinya terhadap Aktivitas Antimakan dan Mortalitas Spodoptera litura F.
Authors: Wahyuni Dian Putri , Yuliani Yuliani
Published: June 2024

Spodoptera litura merupakan salah satu hama yang menyerang tanaman kedelai dan menyebabkan penurunan hasil produksi. Alternatif pengendalian S. litura dengan bioinsektisida. Daun lamtoro dan pepaya berpotensi sebagai bioinsektisida karena mengandung senyawa mimosin, papain dan kimopapain. Penelitian ini bertujuan untuk mengetahui pengaruh jenis ekstrak, konsentrasi ekstrak, serta interaksi keduanya terhadap aktivitas antimakan dan mortalitas S. litura. Penelitian ini menggunakan RAL dua faktor perlakuan yaitu jenis ekstrak daun lamtoro, pepaya dan kombinasinya, konsentrasi ekstrak 5%, 10%, 15% dan kontrol negatif menggunakan aquades serta kontrol positif menggunakan sipermetrin. Data persentase aktivitas antimakan dan mortalitas dianalisis dengan ANOVA dua arah dan dilanjutkan uji Duncan. Hasil penelitian menunjukkan bahwa terdapat pengaruh jenis dan konsentrasi ekstrak serta terdapat interaksi antara jenis dan konsentrasi ekstrak daun lamtoro, pepaya dan kombinasinya terhadap aktivitas antimakan dan mortalitas S. litura. Jenis ekstrak kombinasi pada konsentrasi 15% merupakan perlakuan yang paling efektif dengan persentase aktivitas antimakan sebesar 36,00% dan mortalitas sebesar 80,00%. Sehingga ekstrak daun lamtoro dan pepaya dapat dimanfaatkan sebagai bioinsektisida alternatif pengganti insektisida sintetik.
Pengaruh Ekstrak Daun Kedondong terhadap Penurunan Kadar Kolesterol Total dan Berat Badan Mencit Diabetes Melitus Tipe II
Authors: Adhitama Shendy , Kuswanti Nur , Khaleyla Firas
Published: June 2024

Penderita obesitas berisiko tinggi mengidap diabetes melitus (DM) karena penumpukan lemak yang dapat menurunkan sensitivitas sel. Daun kedondong mengandung flavonoid yang berpotensi menurunkan kadar kolesterol total. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak daun kedondong terhadap penurunan kadar kolesterol total, berat badan, serta dosis yang paling efektif untuk menurunkan kadar kolesterol total dan berat badan mencit DM II. Penelitian ini adalah penelitian eksperimental dengan Rancangan Acak Lengkap (RAL). Penelitian menggunakan 24 ekor mencit jantan yang dibagi menjadi 6 kelompok yaitu KN (normal), KP (DM), KM (metformin), K1 (ekstrak 250 mg/kgBB), K2 (350 mg/kgBB), dan K3 (450 mg/kgBB). Pengukuran kadar kolesterol total menggunakan alat ukur merek EasyTouch. Pengukuran berat badan menggunakan timbangan digital. Data kadar kolesterol total dan berat badan dianalisis dengan uji One Way ANOVA. Hasil penelitian menunjukkan bahwa ekstrak daun kedondong berpengaruh terhadap kadar kolesterol total dan berat badan (p>0,05). Pengaruh paling baik ditunjukkan oleh dosis ekstrak daun kedondong 450 mg/kgBB (K3). Kesimpulannya, dosis ekstrak daun kedondong berpengaruh terhadap penurunan kadar kolesterol total dan berat badan mencit DM tipe II serta dosis 450 mg/kgBB adalah dosis paling efektif dalam menurunkan kadar kolesterol total dan berat badan pada mencit DM II.
Hubungan Keanekaragaman Jenis Bivalvia dengan Kadar Timbal (Pb) Air dan Sedimen di Pantai Joko Moersodo, Lamongan
Authors: Atika Jati Ina Sintya , Sunu Kuntjoro Sunu Kuntjoro
Published: June 2024

Pantai Joko Moersodo berada di pesisir utara Jawa Timur, tepatnya Kabupaten Lamongan. Pantai Joko Moersodo berdekatan dengan tempat Pangkalan Pendaratan Ikan, permukiman penduduk, dan tambak, serta digunakan sebagai tempat pariwisata, sehingga memiliki risiko tercemar logam berat timbal. Bivalvia banyak ditemukan di Pantai Joko Moersodo dan diketahui dapat mengakumulasi logam berat, sehingga digunakan sebagai bioindikator perairan. Tujuan penelitian ini adalah mengidentifikasi dan mendeskripsikan keanekaragaman jenis bivalvia, serta menganalisis hubungan keanekaragaman jenis bivalvia dengan kadar timbal air dan sedimen di Pantai Joko Moersodo. Sampling dilakukan di tiga stasiun yang terdiri atas tiga sub-stasiun. Pada setiap sub-stasiun ditetapkan plot 5x5 m dan terdapat sub-plot dengan luas 1x1 m sebanyak lima titik. Sampel air diukur dengan parameter fisika-kimia. Pengujian kadar timbal air dan sedimen menggunakan metode Atomic Absorption Spectrophotometry. Data dianalisis dengan uji korelasi Pearson untuk mengetahui hubungan keanekaragaman jenis bivalvia dengan kadar timbal air dan sedimen di Pantai Joko Moersodo. Hasil penelitian menunjukkan bahwa bivalvia yang ditemukan di Pantai Joko Moersodo terdiri atas tujuh spesies yang termasuk dalam enam genus dan tiga famili. Indeks keanekaragaman bivalvia termasuk diversitas sedang dengan perairan tercemar sedang. Hubungan keanekaragaman jenis bivalvia dengan kadar timbal air dan sedimen di Pantai Joko Moersodo menunjukkan hasil yang tidak signifikan.
Persepsi dan Apresiasi: Tradisi Wiwit Kopi Masyarakat Desa Carangwulung Kecamatan Wonosalam Jombang
Authors: Putra Pangestu Rachmat Karunia , Indah Novita Kartika
Published: June 2024

Desa Carangwulung, Kecamatan Wonosalam, Jombang merupakan desa di Jawa Timur yang memiliki komoditas tanaman kopi. Tanaman kopi yang dibudidayakan berkaitan erat dengan pengetahuan lokal masyarakat, sehingga menciptakan kearifan lokal berupa tradisi wiwit kopi. Tradisi tersebut bersumber dari persepsi dan apresiasi masyarakat pada tanaman kopi, maka penelitian ini bertujuan untuk mengetahui tingkat persepsi masyarakat dalam tradisi wiwit kopi dan apresiasi masyarakat pada tanaman kopi. Penelitian menggunakan metode deskriptif. Data diperoleh melalui wawancara menggunakan kuesioner dan melalui pertanyaan terbuka. Partisipan penelitian sebanyak 65 orang yang dipilih secara purposive sampling dari setiap dusun di Desa Carangwulung. Analisis data secara kuantitatif menggunakan skala likert serta rumus persepsi dan apresiasi untuk menghitung persentase jawaban kuesioner. Hasil menunjukkan pengetahuan lokal yang dimiliki partisipan berbeda, usia muda memiliki persentase dengan rentang kurang-cukup sementara usia lansia memiliki rentang baik-sangat baik. Hal ini ditunjukkan seperti persepsi usia muda cukup pada makna tradisi sebesar 53,13% dibandingkan usia lansia sangat baik sebesar 88,75%, serta apresiasi usia muda cukup seperti konservasi 59,38% sedangkan usia lansia sangat baik yaitu 85%.
Efektifitas Ekstrak Daun Nicotiana tabacum L. var. Virginia dan Carica papaya L. var Thailand Sebagai Bioinsektisida Terhadap Mortalitas Spodoptera litura F.
Authors: Faizah Rosyidatun Nurul , Dewi Sari Kusuma
Published: June 2024

Spodoptera litura dapat merusak tanaman, sehingga hasil produksi menurun. Petani mengatasi hama menggunakan insektisida kimia, namun jika digunakan dalam jangka panjang dapat menimbulkan dampak negatif. Penggunaan tanaman sebagai bioinsektisida adalah salah satu cara pengendalian yang ramah lingkungan. Kandungan senyawa daun N. tabacum dan C. papaya yaitu alkaloid, flavonoid, tannin, saponin, minyak atsiri, enzim papain, steroid, dan tannin dapat digunakan sebagai bioinsektisida. Penelitian ini bertujuan untuk mengetahui pengaruh jenis ekstrak, konsentrasi ekstrak, serta interaksi keduanya terhadap mortalitas larva S. litura. Penelitian ini menggunakan metode Rancangan Acak Lengkap (RAL) dua faktorial yaitu jenis ekstrak daun N. tabacum, C. papaya, dan kombinasinya serta menggunakan 5 jenis konsentrasi yaitu 2%, 4%, 6%, 8%, dan 10% dengan tiga pengulangan. Analisis data menggunakan uji ANOVA two-way dan dilanjutkan uji post-hoc Duncan. Hasil penelitian menunjukkan terdapat pengaruh jenis dan konsentrasi ekstrak serta terdapat interaksi antara keduanya terhadap mortalitas S. litura. Jenis ekstrak kombinasi pada konsentrasi 10% merupakan perlakuan paling efektif dengan persentase mortalitas sebesar 66,67%.
Isolasi dan Karakterisasi Bakteri Amilolitik, Proteolitik dari Tanah Perkebunan Pepaya dengan Serangan Hama Kutu Putih (Paracoccus Marginatus) di Kebumen
Authors: Irsyadah Naeli , Santosa Slamet
Published: June 2024

Telah dilakukan penelitian tentang isolasi bakteri di tanah perkebunan pepaya dengan serangan hama kutu putih (Paracoccus marginatus) di Kebumen. Penelitian ini bertujuan untuk mengetahui potensi bakteri amilolitik dan proteolitik pada tanah perkebunan pepaya dengan serangan hama kutu putih. Sampel yang digunakan adalah tanah dekat akar tanaman pepaya dengan serangan P. marginatus, tanah pada pepaya yang sehat, dan tanah pada pepaya yang mati. Bakteri dekat akar diisolasi dan dikarakterisasi secara makroskopis dan mikroskopis serta dilakukan uji enzimatik, yaitu uji amilolitik dan uji proteolitik. Hasil isolasi didapatkan sebanyak 8 isolat terbaik dengan kriteria isolat murni, tidak terkontaminasi, tumbuh subur dan menghasilkan produk yang diinginkan, yaitu dengan kode isolat B1, B2, B3, B4, B5, B6, B9 dan B11. Uji amilolitik positif dihasilkan oleh kode isolat B1, B3, B4, B6. Uji proteolitik positif dihasilkan oleh kode isolat B2, B5, B6, B9. Hasil penelitian membuktikan bahwa tanah pada dekat akar tanaman pepaya menghasilkan isolat bakteri yang potensial yang bersifat amilolitik dan proteolitik.
Isolasi dan Evaluasi Aktivitas Antifungi Bakteri Simbion Teripang Pasir (Holothuria scabra) dari Taman Nasional Wakatobi terhadap Malassezia furfur
Authors: Yanti Nur Arfa
Published: June 2024

Malassezia furfur merupakan fungi penyebab penyakit panu yang membutuhkan senyawa antifungi untuk pengobatannya. Senyawa antifungi dapat diperoleh dari bakteri yang bersimbiosis dengan organisme laut. Salah satu kandidat bakteri penghasil senyawa antifungi adalah bakteri Simbion Teripang pasir (Holothuria scabra). Penelitian ini bertujuan untuk memperoleh isolat bakteri yang mampu menghambat pertumbuhan fungi Malassezia furfur penyebab penyakit panu (Pityriasis versicolor). Isolasi bakteri simbion teripang dilakukan menggunakan metode tuang (pour plate). Aktivitas antifungi bakteri simbion dilakukan menggunakan metode difusi sumuran. Hasil penelitian diperoleh 5 isolat bakteri simbion teripang pasir yang memiliki aktivitas antifungi M.furfur. Tiga isolat bakteri yaitu isolat DT1, DT4 dan isolat DT5, menghasilkan senyawa antifungi yang mampu menghambat pertumbuhan M. furfur dengan zona hambat berkisar 8,60 mm-11,30 mm dalam waktu 24 jam. Berdasarkan hasil identifikasi dengan metode profile matching diketahui bahwa Isolat bakteri DT1 dan DT5 termasuk genus Pseudomonas sedangkan isolat bakteri DT4 termasuk genus Bacillus. Dengan demikian, Ketiga isolat bakteri simbion teripang pasir dapat dikembangkan dan diaplikasikan sebagai penghasil bahan obat untuk  penyakit kulit panu.
Species-specific differences in bumblebee worker body size between different elevations: Implications for pollinator community structure under climate change
Authors: Massa Caterina , Hille Ris Lambers Janneke , Richman Sarah Kelley
Published: June 2024

Pollinator populations face growing threats from global climate change, particularly in alpine environments with rapidly rising temperatures. Understanding how bumblebees, critical alpine pollinators, respond to these temperature changes is therefore an important goal. Predicting species’ responses to climate change requires several different approaches, one of which is to compare processes at different elevations, which experience different temperature regimes. Bumblebee body size is linked to fitness through its influence on nutritional requirements and foraging capacity. It is also a highly plastic trait that depends on ecological factors such as temperature. Thus, understanding how body size varies at different elevations may help predict bumblebee fitness under climate change. We collected bumblebee workers from five species in a single growing season, at two distinct elevations in the Swiss Alps. Our study aimed to examine whether body size responses differed among species and across functional traits related to foraging and nesting. Larger body size is thought to confer an advantage under cold conditions; we therefore expected greater body size with elevation, but with species-specific relationships. Contrary to our expectation, not all species were larger at high elevations. Specifically, while two species were significantly larger at high elevation, one (Bombus terrestris) was significantly smaller at high elevation, and two showed no size differences with elevation. Additionally, interspecific variation in body size was greater at low elevations. This suggests a divergence of body size with warming, although local factors may also play a role in shaping functional traits.
Enhancing Wave Function Collapse Algorithm for Procedural Map Generation Problem
Authors: Büyükşar Osman , Yıldız Doğan , Demirci Sercan
Published: June 2024

In this study, the Improved Map Generation Algorithm (GHAO) method is presented to improve traditional methods in procedural map creation. Traditional procedural map generation techniques using noise generation exhibit shortcomings in the consistent composition of a real map with its uniformly distributed features. On the other hand, procedural map creation techniques that use wave function collapse require that some map pieces already exist to create a map. The observed disadvantages were eliminated by using a hybrid technique with the designed GHAO method. The developed algorithm is similar to real maps in terms of the distribution of map regions, does not need 3D model parts, and performs map creation operations without increasing the algorithm's time complexity. The evaluation of IMGA was carried out by coding the method into the Unity game engine.