bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiation doses and accuracy of navigated pedicle screw placement in cervical and thoracic spine surgery: a comparison of sliding gantry CT and mobile cone-beam CT in a homogeneous cohort
Authors: Baumgart Lea , Ille Sebastian , Kirschke Jan S. , Meyer Bernhard , Krieg Sandro M.
Published: June 2023

OBJECTIVE

Multiple solutions for navigation-guided pedicle screw placement are currently available. Intraoperative imaging techniques are invaluable for spinal surgery, but often there is little attention paid to patient radiation exposure. This study aimed to compare the applied radiation doses of sliding gantry CT (SGCT)– and mobile cone-beam CT (CBCT)–based pedicle screw placement for spinal instrumentation.

METHODS

The authors retrospectively analyzed 183 and 54 patients who underwent SGCT- or standard CBCT-based pedicle screw placement, respectively, for spinal instrumentation at their department between June 2019 and January 2020. SGCT uses an automated radiation dose adjustment.

RESULTS

Baseline characteristics, including the number of screws per patient and the number of instrumented levels, did not significantly differ between the two groups. Although the accuracy of screw placement according to Gertzbein-Robbins classification did not differ between the two groups, more screws had to be revised intraoperatively in the CBCT group (SGCT 2.7% vs CBCT 6.0%, p = 0.0036). Mean (± SD) radiation doses for the first (SGCT 484.0 ± 201.1 vs CBCT 687.4 ± 188.5 mGy*cm, p < 0.0001), second (SGCT 515.8 ± 216.3 vs CBCT 658.3 ± 220.1 mGy*cm, p < 0.0001), third (SGCT 531.3 ± 237.5 vs CBCT 641.6 ± 177.3 mGy*cm, p = 0.0140), and total (SGCT 1216.9 ± 699.3 vs CBCT 2000.3 ± 921.0 mGy*cm, p < 0.0001) scans were significantly lower for SGCT. This was also true for radiation doses per scanned level (SGCT 461.9 ± 429.3 vs CBCT 1004.1 ± 905.1 mGy*cm, p < 0.0001) and radiation doses per screw (SGCT 172.6 ± 110.1 vs CBCT 349.6 ± 273.4 mGy*cm, p < 0.0001).

CONCLUSIONS

The applied radiation doses were significantly lower using SGCT for navigated pedicle screw placement in spinal instrumentation. A modern CT scanner on a sliding gantry leads to lower radiation doses, especially through automated 3D radiation dose adjustment.
Does disc distraction after cervical total disc arthroplasty impact range of motion and patient-reported outcomes?
Authors: Federico Vincent P. , Zavras Athan G. , Nie James W. , Butler Alexander J. , Munim Mohammed A. , Nolte Michael T. , Lopez Gregory D. , An Howard S. , Colman Matthew W. , Phillips Frank M.
Published: June 2023

OBJECTIVE

Total disc arthroplasty (TDA) has been established as a safe and effective alternative to anterior cervical discectomy and fusion for the treatment of cervical spine pathology. However, there remains a paucity of studies in the literature regarding the amount of disc height distraction that can be tolerated, as well as its impact on kinematic and clinical outcomes.

METHODS

Patients who underwent 1- or 2-level cervical TDA with a minimum follow-up of 1 year with lateral flexion/extension and patient-reported outcome measures (PROMs) were included. Middle disc space height was measured on preoperative and 6-week postoperative lateral radiographs to quantify the magnitude of disc space distraction, and patients were grouped into < 2-mm distraction and > 2-mm distraction groups. Radiographic outcomes included operative segment lordosis, segmental range of motion (ROM) on flexion/extension, cervical (C2–7) ROM on flexion/extension, and heterotopic ossification (HO). General health and disease-specific PROMs were compared at the preoperative, 6-week, and final postoperative time points. The independent-samples t-test and chi-square test were used to compare outcomes between groups, while multivariate linear regression was used to adjust for baseline differences.

RESULTS

Fifty patients who underwent cervical TDA at 59 levels were included in the analysis. Distraction < 2 mm was seen at 30 levels (50.85%), while distraction > 2 mm was observed at 29 levels (49.15%). Radiographically, after adjustment for baseline differences, C2–7 ROM was significantly greater in the patients who underwent TDA with < 2-mm disc space distraction at final follow-up (51.35° ± 13.76° vs 39.19° ± 10.52°, p = 0.002), with a trend toward significance in the early postoperative period. There were no significant postoperative differences in segmental lordosis, segmental ROM, or HO grades. After the authors controlled for baseline differences, < 2-mm distraction of the disc space led to significantly greater improvement in visual analog scale (VAS)–neck scores at 6 weeks (−3.68 ± 3.12 vs −2.24 ± 2.70, p = 0.031) and final follow-up (−4.59 ± 2.74 vs −1.70 ± 3.03, p = 0.008).

CONCLUSIONS

Patients with < 2-mm disc height difference had increased C2–7 ROM at final follow-up and significantly greater improvement in neck pain after controlling for baseline differences. Limiting differences in disc space height to < 2 mm affected C2–7 ROM but not segmental ROM, suggesting that less distraction may result in more harmonious kinematics between all cervical levels.
Effectiveness of indigenous Rhizobium sp. isolates from peatland soils on soybean (Glycine max L. Merril) growth and production
Authors: Tabrani Gunawan , Dini Isna Rahma , Purnomo Handoko Suryo
Published: June 2023

The low productivity of soybeans can be overcome by cultivating them on peatlands, accompanied by the provision of indigenous Rhizobium strains derived from peatlands. Isolating Rhizobium sp. from peatlands is believed to enhance soybean productivity on such land. This study aims to determine the effectiveness of local Riau Rhizobium sp. isolates for soybean cultivation in Riau peatlands. Six isolates of Rhizobium sp. were used in this study, obtained from plants growing on peatlands: IIMB4, IIRM1, IIRM2 from the rhizosphere of Mucuna bracteata, and IIRA4, IIRA2, IIRA6 from the rhizosphere of Acacia crassicarpa. The experiment followed a completely randomized design (CRD), with each treatment replicated four times. The treatments included control, commercial Rhizobium sp., isolates IIMB4, IIRA2, IIRA6, IIRM2, IIRA4, and IIRM1. The results demonstrated that all indigenous Rhizobium sp. isolates from peatlands, particularly IIMB4, effectively formed symbiotic associations with soybean plant roots, improving growth parameters and increasing soybean production. Nevertheless, it is also necessary to assess the effectiveness of these Rhizobium sp. isolates on various other leguminous plant species to identify the most efficient symbiotic isolates across different leguminous crops.
EVALUASI PENERAPAN SISTEM INFORMASI PENDAFTARAN ONLINE DI RUMAH SAKIT KUMALA SIWI KUDUS DENGAN HOT-FIT MODEL
Authors: Nugraha Ega , Anindya K. W.
Published: June 2023

Rumah sakit sebagai salah satu fasilitas pelayanan kesehatan perorangan merupakan bagian dari sumber kesehatan yang sangat diperlukan dalam mendukung penyelenggaraan upaya kesehatan. Sistem informasi rumah sakit dapat mendorong peningkatan efisiensi dan efektivitas pelayanan di rumah sakit. Proses perencanaan sistem informasi dalam rumah sakit merupakan salah satu poin penting yang harus dipersiapkan. Rumah Sakit Kumala Siwi Kudus sudah mulai menerapkan pendaftaran online, tetapi dalam perencanaanya Rumah Sakit Kumala Siwi Kudus masih pada tahap penerapan awal sehingga dalam penerapan mengalami beberapa kendala. Apabila dilihat dari manfaat yang dihasilkan dari sistem tersebut, maka perlu dilakukan evaluasi untuk mengetahui keberhasilan penerapannya dengan menggunakan model evaluasi sistem informasi salah satunya Human Organization Technology-FIT (HOT-FIT). Pengumpulan data primer dilaksanakan dengan wawancara dan hasil kuesioner yang dilakukan terhadap subjek penelitian. Data yang diperoleh merupakan gambaran keadaan saat penelitian dilaksanakan (cross sectional). Hasil dari penelitian ini menunjukkan adanya pengaruh signifikan pada konstruk kualitas sistem terhadap konstruk penggunaan sistem.
ANALISIS KEPUASAN KONSUMEN TERHADAP KUALITAS PRODUK DAN PELAYANAN KEDAI KOPI DI KABUPATEN SLEMAN
Authors: Putra Iqbal Suandhika , Ismiasih Ismiasih , Nurjanah Danik
Published: June 2023

ABSTRACTThe development of the business world today is increasingly advanced and growing rapidly. Each business seeks to increase its competitiveness by improving the quality of products and services. This study aims to analyze consumer satisfaction on coffee shop product and service quality in Sleman-DIY Regency. The method of sample determination using the incidental sampling method. In this method the sample chosen by sudden or by presence opportunity at the research location. Respondents in the study were 90 respondents who were taken from three coffee shops with 30 samples each. The types of data used primary data and secondary data. Data analysis used the Customer Satisfaction Index (SCI) method. Based on the results of the study, it is known that the level of consumer satisfaction on product and service quality at coffee shops A, B, and C in Sleman Regency, DIY was very satisfiy.ABSTRAKPerkembangan dunia bisnis saat ini semakin maju dan berkembang pesat. Masing-masing bisnis berupaya untuk meningkatkan daya saingnya dengan perbaikan pada kualitas produk dan pelayanan. Penelitian ini dilakukan bertujuan untuk menganalisis kepuasan konsumen terhadap kualitas produk dan pelayanan terhadap kedai kopi di Kabupaten Sleman-DIY. Metode penentuan sampel menggunakan metode sampling incidental yaitu teknik penentuan sampel dengan cara spontan berdasarkan keberadaan responden di lokasi penelitian. Responden dalam penelitian sebanyak 90 responden yang diambil dari tiga kedai kopi dengan masing-masing kedai sebanyak 30 sampel. Jenis data yang digunakan yaitu data primer dan data sekunder. Analisis data menggunakan metode Customer Satisfaction Index (CSI). Berdasarkan hasil penelitian diketahui bahwa tingkat kepuasan konsumen terhadap kualitas produk maupun kualitas pelayanan pada kedai kopi A, B dan C di Kabupaten Sleman DIY adalah sangat puas.
Mentilin (Tarsius bancanus) The Smallest Primate at The Taman Kehati Pelawan, Central Bangka
Authors: Hasibuan Ratna Sari , Agus Seftian Pracahyo  , Miftahul Ihsan
Published: June 2023

One of the primitive primates and the smallest nocturnal is Mentilin or Tarsius. Mentilin (Tarsius bancanus) is an endemic animal scattered on the islands of Sulawesi, Kalimantan, Bangka and Belitung. Mentilins are protected animals and are listed in CITES Appendix II. The existence of forest degradation on Bangka Island due to illegal logging, conversion of land to plantation land, and illegal tin mining by the community and companies on a large scale has caused the mentilin’s habitat to decrease. This study's purpose was to determine the total population of mentilin and determine the habitat of mentilin in the Pelawan Forest. The method used is line transect and vegetation analysis. The results of this study were a total of 6 Mentilin found from two groups and a tree-level diversity of 1.67; Pole 2.48; 3.41 saplings and 3.40 seedlings. Mentilin density in Pelawan Forest is 21.4 mentilin per km2, with a sex ratio of 1:2 Dominated by Pelawan Plants.
The effect of individual morality, information asymmetry and organizational culture on the tendency of accounting fraud
Authors:   Accounting Department, Dhyana Pura University, Sari Ni Putu Yunika Tiffany Rachma , Pradnyani Ni Luh Putu Sri Purnama ,   Accounting Department, Dhyana Pura University, Cahyadi Luh Diah Citra Resmi ,   Accounting Department, Dhyana Pura University
Published: June 2023

This study aims to determine the effect of individual morality, information asymmetry and organizational culture on fraud tendencies. This research was conducted at LPD in Kerambitan District. The research method used in this study is a quantitative research method with primary data obtained from questionnaire data as measured by a Likert scale. The population of this study were LPD employees in Kerambitan District, while the sampling method used was purposive sampling with a total sample of 114 respondents. Data analysis used multiple linear regression using SPSS 26. Based on the results of the study, it was shown that individual morality has a negative influence on the tendency of accounting fraud. Information asymmetry has a positive effect on the tendency of accounting fraud. Organizational culture has a negative effect on the tendency of accounting fraud. The advice that researchers can give is to internal supervisory bodies (panureksa) give warnings or sanctions to employees who have bad morals and do not apply organizational culture and always supervise the preparation of financial reports to minimize fraud in the preparation of financial reports.
Analysis of factors influencing the use of accounting information on SMEs in Badung Regency
Authors:   Accounting Department, Universitas Dhyana Pura, Indonesia, Artaningrum Rai Gina , Sumiari Kadek Nita ,   Accounting Department, Politeknik Negeri Bali, Indonesia, Lasmini Ni Nengah ,   Accounting Department, Politeknik Negeri Bali, Indonesia
Published: June 2023

This study aims to analyze the level of education, business scale, accounting training, accounting knowledge, and the use of accounting information in micro, small, and medium enterprises in the Badung district. This research is quantitative in nature, and the data used consists of primary data obtained by distributing questionnaires to MSME actors in the Badung regency. The population of this study comprises all MSMEs registered in the Badung Regency who have paid their annual taxes, amounting to 3,350 MSMEs. The sample for this study was selected through simple random sampling, utilizing the Slovin formula. The results revealed that the level of education, accounting training, and accounting knowledge had a positive effect on the use of accounting information in micro, small, and medium enterprises in the Badung district. However, business scale exhibited a negative effect on the use of accounting information in micro, small, and medium enterprises in the Badung district.
MODIFICATION OF THE DUST COLLECTOR TOOL ON A 3 AXIS CNC ROUTER MACHINE FOR WOOD WORKING
Authors: Yahya Ahmad , Koswara Engkos , Rachmat Asep , Dewi Jannati Eidelweis
Published: June 2023

Based on the results of research in Majalengka Regency, it was found that there were 200 semi-finished wood processing secondary industries, spread over 26 sub-districts with the type of wood used being dominated by teak, mahogany, these types of wood are used for semi-finished materials in the form of frames, doors, windows, cabinets, sideboard and chairs. There is also production of wood that is native to Indonesia, namely wood carving. Wood carving has its own uniqueness because it is a human creation based on an aesthetic sense according to what the human himself wants. Wood carving works of art are usually created using sculpting techniques. The creation of works of wood carving with the arrangement of elements so that meaningful elements are formed and one must have creative sculpting skills to produce works that are good, attractive and have meaning and high aesthetic value as well as being useful in people's lives.
DESIGN OF HOUSEHOLD-SCALE BIODIGESTER FROM COW MANAGEMENT
Authors: Fauzy Moch Reza , M Yunus Riza , Rachmat Asep
Published: June 2023

Biogas is one solution to overcome community difficulties due to rising fuel prices and the scarcity of LPG gas, this technology can be immediately applied, especially for cattle breeders. Utilizing cow dung that is processed anaerobically in a digester which will produce methane gas as an alternative energy. In planning this household-scale biogas device, there are several components designed including a digester with a volume capacity of 400L with a filling capacity of 2/3 of the digester volume, the material used is HDPE plastic (High Density Polyethylene) and a holding capacity of 147 L which produces a flash time. fire for 20.01 minutes for 15 days of the fermentation process. Where the lowest pressure is obtained on the 3rd day with a pressure of 104.668,73 N/m2, and the maximum pressure is on the 12th day with a maximum pressure of 107.201,85 N/m2i. simulation using solidwork software results in the digester construction which is planned to be used because it has a fairly good level of security
THE EFFECTIVENESS OF ETHANOL EXTRACT OF JAMBLANG LEAVES (Syzygium cumini L.) IN INCREASING HDL LEVELS IN WISTAR RATS MODELS OF METABOLIC SYNDROME
Authors: Muthmainah Muthmainah , Nurwati Ida , Handayani Selfi , Pakha Dyonisa Nasirochmi
Published: June 2023

One of the characteristics of metabolic syndrome (MetS) is the low high-density lipoprotein (HDL) levels. Jamblang leaves (Syzygium cumini L.) contain various phytochemicals, which have antihyperglycemic, antihyperlipidemic, and antioxidant properties. This study aims to demonstrate the effectiveness of ethanol extract of jamblang leaves in increasing HDL levels in the Wistar rats model of MetS. A pretest-posttest with a control group design was conducted using 30 male Wistar rats, divided into five groups randomly, with six rats for each group.Â  Here, KN means normal control group, K- negative control group, and P1, P2, and P3: treatment groups that were administered the 100 mg/kg/day, 150 mg/kg/day, and 200 mg/kg/day of ethanol extract of jamblang leaves for 28 days, respectively. The rat MetS model was developed by administering the high-fat fructose diet and streptozotocin-nicotinamide. The data were analyzed using paired t-test and one-way ANOVA (Î±=0.05). This study found that extract administration in P2 and P3 increased HDL levels significantly, but not with the P1 group. However, HDL levels in P1 were significantly higher compared to the K- group. Moreover, increasing the dose was significantly followed by higher HDL levels, although the highest dose did not reach the HDL level as in the KN group.
THE RISK OF DEGENERATIVE DISEASES BASED ON ENERGY CONSUMPTION AND EXERCISE HABITS
Authors: Yuni Gumala Ni Made , Nursanyoto Hertog , Ambartana I Wayan
Published: June 2023

Obesity triggers the risk of degenerative diseases. An unhealthy diet and insufficient physical activity have been contributing to the rapid increase in obesity prevalence. This study aims at determining the differences in the risk of degenerative diseases based on energy consumption and exercise habits of City Disaster Management Board/DMB members, especially in Denpasar City. This research is an observational study, targeting all members of Denpasar DMB as a population. Samples were taken purposively with a total of 126 people. The risk difference was tested using chi-square, and the estimated risk of degenerative diseases was analyzed using the Mantel-Haentzel odds ratio. The risk of degenerative diseases based on energy consumption shows a significant risk only in the group of people who did not have exercise habits (Q-suare=4.53; p=0.03), with an estimated risk that is also significant (OR=2.48; 95% CI= 1.07 - 5.74). The estimated risk results indicated that exercise habit is a potential confounding variable in the risk of degenerative diseases based on energy consumption. Lowering energy consumption is not effective enough to prevent the increase of degenerative disease risk, and prevention of new risks of degenerative diseases must include regular exercise.
Stratejik İnsan Kaynağının Geliştirilmesinde Kariyer Planlaması Eğitimi: Süleyman Demirel Üniversitesi Örneği
Authors: ÖZMEN Halil İbrahim , ÇARIKÇI İlker Hüseyin , DULUPÇU Murat Ali
Published: June 2023

Üniversite öğrencileri, stratejik yönetim düşüncesinde kaynak tabanlı yaklaşım bağlamında, bir ülkede yükseköğrenim düzeyinde eğitim alan kişiler olarak ülkelerin gelecek hedeflerine ulaşılmasında stratejik bir unsur konumundadır. Bu noktada, üniversite öğrencilerinin öncelikle kendi geleceklerini şekillendirme üzerine oluşturacakları kurgular olarak “Kariyer Planları” özel bir öneme sahiptir. Son yıllarda yükseköğretim sisteminde üniversite öğrencilerine yönelik olarak gerçekleştirilen kariyer planlama eğitimlerinde bir artışın olması bu önemin bir sonucudur. Bu çalışmada Cumhurbaşkanlığı İnsan Kaynakları Ofisi koordinasyonunda 2020-2021 Eğitim Öğretim Yılı Güz Döneminde Süleyman Demirel Üniversitesinde müfredata eklenilen “KRY001 Kariyer Planlama ve Çalışma Hayatına Giriş” dersi özelinde gerçekleştirilen süreçler ve elde edilen çıktılar ortaya konmaya çalışılmıştır.
Gümrük İşletme Bölümüne Yönelik Öğrenci Algıları: Fenomenolojik Bir Araştırma
Authors: GÜRSOY İpek , TURGUT Muhammed
Published: June 2023

Bu çalışmada, ülkemizde birçok üniversitede yeni açılmakta olan Gümrük İşletme bölümüne yönelik öğrenci algılarının tespit edilmesi amaçlanmıştır. Yapılan araştırmada, nitel araştırma yöntemlerinden fenomenolojik araştırma deseni; nitel örnekleme yöntemlerinden birisi olan ölçüt örnekleme kullanılmıştır. Yarı yapılandırılmış görüşme gerçekleştirilerek Tarsus Üniversitesi, Yeditepe Üniversitesi, Iğdır Üniversitesi ve Mehmet Akif Ersoy Üniversitesi’nde eğitim almakta olan 38 Gümrük İşletme bölümü öğrencisinden veriler toplanmıştır. Betimsel analiz tekniği ile toplanılan veriler analiz edilmiştir. Geçerlilik ve güvenilirliğin tespiti TAPUSAS kriterleri ile belirlenmiştir. Araştırma sonucunda, Gümrük İşletme bölümünün yeni bir bölüm olması, Türkiye’nin uluslararası ticaret ve lojistikte büyüyen bir ülke olması, çevreleri tarafından bölüm ile ilgili olumlu referanslar verilmesi, bölümün gelecekte öneminin daha da artacağı ve iş bulma avantajı sağlayacağı düşüncesi gibi faktörlerin öğrencilerin bölüm tercihinde etkili olduğu tespit edilmiştir. Bununla birlikte, öğrencilerin %71,05 gibi büyük bir çoğunluğunun kamu sektöründe çalışmak istediği sonucuna ulaşılmıştır. Ayrıca, Gümrük İşletme bölümü için Gümrük İşlemleri ve Yönetimi, Sınır Yönetimi, Gümrük ve Uluslararası Ticaret, Gümrük Müşavirliği, Gümrük ve Ticari İşletme, Gümrük İşletmeciliği ve Lojistik olmak üzere çeşitli isim önerileri geliştirilmiştir.
Akademisyenlerin Kariyer Kimliğinin İnşası: Seçkin Akademisyenler Üzerine Bir Çoklu Vaka Çalışması
Authors: BİRCAN ALTINSOY Hatice Merve , ERDOĞMUŞ Nihat
Published: June 2023

Son dönemde dünyada ve Türkiye’de akademisyenler değerlendirilirken performans ve sıralama öne çıkmaktadır. Akademisyenlerle ilgili yapılan çalışmalar genel itibariyle akademisyenleri listelemeye yönelik olup, akademisyenlere başarıyı getiren yetişme süreçlerinin ele alınmadığı görülmektedir. Bu kapsamda araştırmanın amacı, seçkin akademisyen olarak tanımlanan başarılı akademisyenlerin kariyerlerinin gelişim ve kariyer kimliklerinin inşa süreçlerini incelemektir. Nitel araştırma yöntemiyle tasarlanan araştırmada, vaka çalışması yaklaşımı benimsenmiştir. Araştırma iki aşamalı yürütülmüştür. İlk aşamada sosyal ve beşerî bilimler (a), fen ve mühendislik bilimleri (b) ve sağlık bilimleri ve yaşam (c) alanlarından birer akademisyene ait önce doküman incelemesi yapılmış, ikinci aşamada ise akademisyenlerle mülakatlar gerçekleştirilmiştir. Deşifre edilen mülakat dokümanları anlatı analizine tabi tutulmuştur. Sonuç olarak seçkin akademisyenlerin kariyer kimliklerini merak ve sürekli çalışma üzerine kurdukları görülmüştür. Kariyer kimliklerini inşa ederken rol modeller kariyerlerini çalışma disiplini ile ve akademik olarak etkilemiştir. Seçkin akademisyenlerin doktora süreçlerinde doktora tezi onları geliştirmiş ve danışmanları onları olumlu yönde etkilemiştir. Çıkardıkları yayınlar kariyerlerinin merkezindedir ve kariyer başarılarının göstergesidir. Seçkin akademisyenler akademik çalışmalarını ekip çalışması ve iş birliği ile yürütmektedirler. Aynı zamanda kurdukları uluslararası ilişkiler de bu çalışmalarına destek olmuştur. Akademisyenlerin yaptıkları akademik işler yanında, vakitlerini alan yayın dışı akademik işleri de mevcuttur. Bütün bunların yanında seçkin akademisyenlerin önemli başarıları vardır ve kariyer kimliklerinde bu başarıyı vurgulamaktadırlar.
The problems of unifying information in the patient leaflets in Ukraine during the COVID-19 pandemic and wartime
Authors: Качерай Ю. В. , Заболотня З. О. , Заліська О. М. , Мудрак І. Г. , Кушта О. М.
Published: June 2023

The information in the patient leaflets on the medicines must be unified, have a good structure and be clearly presented to the patient for prevent information asymmetry. We substantiated and worked a methodic of comparative analysis of antibiotic using for example of 74 instructions on the drug of one INN, which are registered on the markets of Ukraine, EU countries and Japan. Ways to unify information in to improve patient awareness of the correct use of drugs, especially antibiotics, are substantiated and presented.

Aim – to conduct a comparative analysis of the patient leaflets for antibacterial medicines and determine the presence or absence of information asymmetry using the example of antibiotics of one INN that are registrated on the Ukrainian market or they received as a humanitarian aid from Europe in wartime, in order to establish inconsistencies in the information structure and data in the information leaflets.

The objects were information leaflets for antibiotics: azithromycin, amoxiclav, amoxicillin, zinnate, cefazolin, cefatoxin. Methods were informational, comparative and content analysis. Methodology of information asymmetry analysis using the example of information leaflets for the medicine azithromycin from various manufacturers available on the market of Ukraine.

As a result, significant differences were established in 3 sections: «Indications», «Peculiarities of use», suspension preparation, etc. Significant differences were found in the information leaflets for prescribing azithromycin for skin infections, which requires immediate unification in the information leaflets of data for correct prescribing by a doctor using an electronic prescription and good use for a treatment course. It was established that in the  for azithromycin from one manufacturer, which is on the market of Ukraine and EU countries, significant differences in information were found in 10 sections of the information leaflets, which requires the unification of information accordingly.

We have reasoned that the information leaflets should contain information that is important for the correct use of the medicine, in order to prevent potentially dangerous consequences that may arise from incorrect preparation or dosage. We grounded the information leaflets should include a section on the disposal of expired or unused medicines to harmonize with the information leaflets іn the EU countries.
The Standard Model Symmetry and Qubit Entanglement
Authors: Szangolies Jochen
Published: June 2023

Research at the intersection of quantum gravity and quantum information theory has seen significant success in describing the emergence of spacetime and gravity from quantum states whose entanglement entropy approximately obeys an area law. In a different direction, the Kaluza-Klein proposal aims to recover gauge symmetries by means of dimensional reduction of higher-dimensional gravitational theories. Integrating both, gravitational and gauge degrees of freedom in \(3+1\) dimensions may be obtained upon dimensional reduction of higher-dimensional emergent gravity. To this end, we show that entangled systems of two and three qubits can be associated with \(5+1\) and \(9+1\) dimensional spacetimes respectively, which are reduced to \(3+1\) dimensions upon singling out a preferred complex direction. In the latter case, this reduction is invariant under a residual \(SU(3) \times SU(2) \times U(1) /\mathbb{Z}_6\) symmetry, the Standard Model gauge group. This motivates a picture in which spacetime emerges from the area law-contribution to the entanglement entropy, while gauge and matter degrees of freedom are due to area law-violating terms. We remark on a possible natural origin of the chirality of the weak force in the given construction.
Effect of daylight and air oxygen on nanozymatic activity of unmodified silver nanoparticles: Shelf-stability
Authors: Hormozi Jangi Saeed Reza
Published: June 2023

In this work, unmodified silver nanoparticles were synthesized by a simple and cost-efficient method and then characterized by TEM imaging and UV-Vis. spectroscopy.  Thereafter, their nanozymatic activity was investigated by catalyzing the oxidation of 3,3’,5,5’-tetramethyl-benzidine (TMB) as the standard peroxidase substrate. The results exhibited a specific activity as high as 5.4 µM min-1 for the as-prepared unmodified silver nanoparticles. Afterward, the effect of daylight and air oxygen on the peroxidase-like activity of these nanozymes was checked within 7 days. The results revealed that the activity of unmodified silver nanoparticles was approximately retained at about 75%, and 63% after 7 days exposing daylight and air oxygen, in order. The shelf-self of the as-prepared nanozymes was also investigated at  4 ℃ under dark conditions, revealed that these nanozymes saved  about 96% of their initial activity after 10 days of storage at 4 ℃ under dark conditions.

KEYWORDS:Unmodified silver nanoparticles; Peroxidase-like nanozymes; Air oxygen; Daylight; Shelf-stability
Nasal washes in chronic rhinosinusitis, review article
Authors: Benítez Alicia , Toso Sandra , Mena Carlos , Pérez Enrique
Published: June 2023

Chronic rhinosinusitis (CRS) is a chronic condition of inflammation in the mucosa of the paranasal sinuses that is associated with a significantly impaired quality of life, which motivates the constant study of therapies for its control and cost reduction. The cutting edge of clinical management for CRS is topical therapy. The advantages of topical medical therapy include direct administration of the drug into the diseased tissue, the possibility of administering higher local concentrations of the drug and minimizing systemic absorption which is not without adverse effects, thus becoming an important strategy in the management of CRS. The objective of this literature review is to formally review and identify topical medical therapy strategies and promote an evidence-based approach to their use. A literature review was conducted based on a keyword search. The computerized databases of PubMed, ElSevier and ResearchGate were accessed. We included articles highlighting the results of the use of topical therapies in CRS and that the type of study was a clinical trial. This review identified and evaluated the literature on topical therapy strategies for CRS: saline irrigation, topical antibiotics, topical steroids, and topical antifungals. Topical therapy has become an important tool in the treatment arsenal for CRS. Based on a review of the literature, nasal irrigation with saline and topical steroid sprays are the most evidence supportive. Nonstandard topical nasosinusal steroid therapies may be an option for managing CRS.
Development of Investment Activities of the City
Authors:   Kremenchuk National University named after Mykhailo Ostrogradskyi, Trunina Iryna , Chumakova Anna ,   Kremenchuk National University named after Mykhailo Ostrogradskyi
Published: June 2023

The article examines the essence of investment activity and its impact on the development of the city. The relevance of increasing the inflow of investments by creating favorable conditions for the development of green tourism is emphasized. This study used the findings of foreign and domestic scientists and global practices of green tourism functioning as an integral part of the city’s attractiveness among investors. It has been established that rural green tourism is currently one of the promising areas of development of the tourism industry of foreign countries, the rapid development of which in the last year is due to quarantine restrictions. It combines a wide range of different types of tourism based on the use of natural resources. It was found that the accelerated development of green tourism can play the role of a catalyst for investments in the region and the country as a whole. The subject of the study is a set of theoretical, methodological and practical aspects of increasing the effectiveness of the development of green tourism in the business environment. The purpose of this work is to substantiate theoretical and methodological approaches and develop practical recommendations for the development of green tourism in Ukraine, increase investment income, and analyze internationally recognized tools for stimulating the development of green tourism in the world. The proposed incentive tools will contribute to ensuring the appropriate level of investment in the regions of Ukraine and the gradual greening of technological processes in accordance with international environmental requirements, which will lead to an automatic increase in the activity and efficiency of environmentally oriented innovative activities of the country’s enterprises. The state of green tourism in Ukraine and European countries is analyzed. The work highlights the negative and positive sides of modern green tourism in Ukraine and describes the main recommendations for the development of this area and increasing its level of attractiveness for foreign and domestic investors (on the example of the Poltava region). The obtained result will allow more systematic and qualitative implementation of «greening» in the cities of Ukraine.
The Influence of State Support Levers on the Development Strategy of Agricultural Enterprises
Authors:   Central Ukrainian National Technical University, Shynkar Dmytro
Published: June 2023

The Influence of State Support Levers on the Development Strategy of Agricultural Enterprises
Energy Transformations in the Context of Modern Worldview Paradigms
Authors:   Volodymyr Vynnychenko Central Ukrainian State Pedagogical University, Semeniuk Larisa , Semeniuk Andrii ,   Institute for Economics and Forecasting, National Academy of Science of Ukraine
Published: June 2023

The article aims to analyse the worldview theories, which have become the basis for the concept of sustainable energy transformations. A number of ideas explaining the close connection between energy and environmental transformations, economic and technological progress of society and the state of the environment are considered. Energy transformations have become the research object due to the processes such as, on the one hand, the understanding of the future energy resources crisis, and on the other, the awareness of environmental problems that can lead to the real threat to humanity. The purpose of the article is to investigate philosophical concepts that lead to a new paradigm of satisfying human, and community needs in energy in the context of international and national economic strategies. The civilizational importance of the problem mentioned above and the urge to solve it at the global and local levels stimulates the curiosity of scientists and the activity of scientific and practical research in various fields. The object of scientific exploration is the economic and environmental effects of implementing renewable energy sources, the investment attractiveness of such projects; the innovative processes of renewable energy implementation and development are studied; environmental impact of various infrastructure elements is evaluated, in particular - in local systems; possibilities of the efficient architecture of the energy and ecological components of the urban environment, territorial communities, etc. are analysed. The concepts of environmental philosophy regarding the need for a harmonious combination of human and environmental needs are increasingly being taken into account in the development of state economic strategies and programs. The article states that an aspect of environmental consciousness change, building a new, socially responsible thinking of an economically and socially active part of society, and, ideally, most of humanity will remain of high importance for achieving sustainable development goals, in particular, sustainable modes of energy consumption.
Investigation of Social Studies Teacher Candidates’ Attitudes Towards Renewable Energy Sources
Authors: Karali Mehmet Akif , Ginesar Özkan
Published: June 2023

This research was prepared in order to examine the attitudes of social studies teacher candidates towards renewable energy sources in terms of various variables. Convenient sampling, one of the purposeful sampling methods, was preferred in the research and the sample group of the research consists of 250 teacher candidates, who are the last level students of universities who teach social studies. In the research, the data were collected by taking the necessary permissions and transferring the scale used to the online environment, taking into account the cost and economic conditions. The Attitude Scale Towards Renewable Energy Sources developed by T. Güneş, K. Alat, and A. İ. C. Gözüm, was used after obtaining the necessary permissions. In addition, the demographic information form prepared by taking the necessary expert opinion within the scope of this research was used as a data collection tool in the research. The Attitude Scale Towards Renewable Energy Sources used in the research was prepared in a 5-point Likert type consisting of 26 items. The causal comparison design, which is among the quantitative methods, was preferred in the research. The data obtained in the study were analyzed using independent groups t-test and one-way analysis of variance (ANOVA).
"You Must Prophesy Again": The Mission of God's People in Revelation 10-14
Authors:   ,   Andrews University, de Aguiar Adenilton
Published: June 2023

The primary task of this study was to delineate the theology of mission in the book of Revelation, with a focus on chaps. 10–14 and special attention to the people of God as participants in the mission of God. The historical survey demonstrated that the theology of mission conveyed by the book of Revelation is a topic broadly neglected in recent scholarship and, hence, requires an in-depth treatment. The object of research was addressed from a biblical-theological perspective by means of an exegetical analysis of relevant passages and key terms that were identified on the basis of a semantic field approach. Nine semantic fields of mission in Revelation, including their elements, were listed. This fact alone demonstrates that Revelation has more to say about mission than one could think on first reading. There is more on mission in Revelation than one could identify by searching only for sending terminology. Mission, in this sense, refers to God's initiative to bring humanity back to him by means of agents divinely commissioned. In Revelation, God uses his end-time people to present the last message of warning to this world. This study demonstrates that Revelation 10–14 focuses on the commission of the end-time church, God's remnant. The commission itself is found in 10:8–11:2. Revelation 11:3–13 shows how such a commission is accomplished, and Revelation 14:6–13 presents the content of the end-time message to be proclaimed to the world. In turn, Revelation 12–13 indicates that the cosmic conflict between God and Satan is the theological background underlying the missionary activity of God's end-time people. More particularly, this section of the book shows that mission is accomplished amid severe opposition by Satan and his allies on earth. Finally, this study has pointed out that the heavenly announcement in 11:15, "The kingdom of the world has become the kingdom of our Lord and of his Christ, and he shall reign forever and ever" points to the fulfillment of all God's covenantal promises and, hence, the completion and triumph of God’s mission through the establishment of his everlasting kingdom. Thus, Revelation presents the final chapter of the beautiful story of the missio Dei!
Prevenção e controle do câncer no Brasil. Ações do Pro-Onco/INCa
Authors: Lopes Emilia Rebelo , Abreu Evaldo de , Rezende Magda Cortes , Lavor Mariângela Freitas
Published: June 2023

O trabalho faz uma análise histórica da situação do câncer no Brasil, demonstrando que as ações de controle da doença sempre foram eminentemente curativas em detrimento das preventivas e de diagnóstico precoce. Aponta os dados epidemiológicos que caracterizam a doença como um problema de saúde pública, as dificuldades e estrangulamentos para uma melhor atenção. Finalmente descreve as iniciativas governamentais tomadas com o objetivo de mudar tal quadro e as atividades da Coordenação de Programas de Controle de Câncer (Pro-Onco), órgão do Instituto Nacional de Câncer, que é atualmente o responsável pelas ações de controle do câncer no país.
Tratamento do mieloma múltiplo com VMCP: revisão de 52 casos
Authors: Pinto Carlos Frederico Distéfano , Silva Alexandre J. Fenelon , Moreira Wagner Brant , Cabral Filho Sebastião , Nascimento Eduardo , Lopes Eugênio B. , Brandão Eduardo C. , Teixeira João Augusto M. , Vieira Maria do Carmo , Alvares Maria N. , Novaes Nedda Maria V.
Published: June 2023

Cinqüenta e dois pacientes estudados entre novembro de 1987 e agosto de 1992 tendo sido submetidos a um ou mais ciclos de quimioterapia com VMCP (vincristina 2 mg IV dl; melphalan 4 mg/m2 VO d2-5; ciclofosfamida 100 mg/rrf VO d2-5 e prednisona 100 mg VO d2-5 - repetidos a cada 28 dias, ou conforme a toxicidade hematológica). Vinte e seis pacientes foram submetidos a radioterapia concomitante. Foi utilizado o estadiamento proposto pelo SWOG (Durie e Salmon, 1975), onde 15 (28,8%) pacientes foram estadiados como IIIA e 32 (61,5%) como IIIB, quatro (7,4%>) como II e um (2,2%) como I. Os critérios de resposta foram os mesmos adotados pelo SWOG; porém, consideramos também como Resposta Parcial (RP) a melhora do PS em um ponto ou mais. Sete pacientes entraram em Remissão Completa, 12 em Remissão Parcial e 20 foram considerados com Doença Está vele 13 não responderam ao tratamento. A Sobrevida Mediana para todos os pacientes, calculada pelo método de Kaplan-Meier, foi de 41 meses. A toxicidade foi tolerável na maioria dos pacientes, sendo grau 3-4 em 16 (30,8%) pacientes em pelo menos um episódio. A principal toxicidade dose limitante foi hematológica. Três pacientes morreram por leucopenia e infecção e um por toxicidade gastrointestinal (7,6%>). Oito pacientes estão perdidos do follow-up. Os autores consideram o esquema eficaz e com resultados compatíveis com os da literatura, com toxicidade dentro das expectativas.
ANALISIS KOMPARASI PENDAPATAN PENGERAJIN SAPU IJUK DENGAN SAPU LIDI DI DESA MEDAN SENEMBAH KECAMATAN TANJUNG MORAWA KABUPATEN DELI SERDANG
Authors: Husna Lailatul
Published: June 2023

Penelitian ini bertujuan untuk mengetahui apa saja Analisis Komparasi Pendapatan Pengerajin Sapu Ijuk Dengan Sapu Lidi Di Desa Medan Senembah Kecamatan Tanjung Morawa Kabupaten Deli Serdang. Tujuan Penelitian ini : (1) Untuk menganalisis pengaruh produksi, harga jual, pengalaman bekerja, jam kerja terhadap pendapatan pengerajin sapu ijuk di Desa Medan Senembah Kecamatan Tanjung Morawa Kabupaten Deli Serdang. (2) Untuk menganalisis pengaruh produksi, harga jual, pengalaman bekerja, jam kerja terhadap pendapatan pengerajin sapu lidi di Desa Medan Senembah Kecamatan Tanjung Morawa Kabupaten Deli Serdang.(3) Untuk menganalisis komparasi pendapatan pengerajin sapu ijuk dengan sapu lidi di Desa Medan Senembah Kecamatan Tanjung Morawa Kabupaten Deli Serdang. Dalam penelitian ini sampelnya adalah pengerajin sapu ijuk 40 orang dan 40 pengerajin sapu lidi. Metode analisis yang di gunakan adalah regeresi linier sederhana dengan alat bantu perangkat SPSS 21. Hasil Penelitian ini (1) Hasil Penelitian uji t (Serempak) dan uji p (parsial) pada variabel produksi, harga jual, pengalaman bekerja, dan jam kerja sangat berpengaruh nyata terahadap pengerajin sapu ijuk dan pengerajin sapu lidi. (2) Nilai koefisien determinasi (R square) Pedagang kaki lima dan pedagang keliling adalah 0,995 dan 0,986. (3) Pendapatan pengerajin sapu ijuk rata-rata sebesar Rp462.300,- sedangkan pengerajin sapu lidi rata-rata sebesar Rp677.000,- jadi selisih pendapatan rata-rata dari sapu ijuk dan sapu lidi adalah sebesar Rp214.700,-.
ANALISIS PENDAPATAN USAHATANI KARET RAKYAT(Hevea brasiliensis Muell Arg)
Authors: Al Rasyid Harun
Published: June 2023

Karet merupakan salah satu komoditas perkebunan dengan nilai ekonomis tinggi.Oleh karena itu, tidak salah jika banyak yang beranggapan bahwa tanaman karet adalah salah satu kekayaan Indonesia.Rendahnya produktivitas karet rakyat menyebabkan  rendahnya produksi karet dan pendapatan dari usaha tani karet juga  mempengaruhi rendahnya pendapatan rumah tangga petani sedangkan kebutuhan  hidup petani tetap bahkan meningkat sehingga mendorong petani meningkatkan  pendapatannya dengan melakukan eksploitasi penyadapan kurang baik dan  berlebihan yang menyebabkan tanaman karet menjadi rusak.Penelitian ini dilakukan untuk menganalisis pendapatan petani karet rakyat.Untuk menganalisis kelayakan usahatani karet rakyat.Untuk mengetahui pola pemasaran karet rakyat yang ada di derah penelitian.Penelitian yang dilakukan ini berjenis penelitian kuantitatif dengan bentuk analisis dan subjek yang dijadikan sumber dalam penelitian ini adalah petani karet rakyat.Data yang digunakan adalah data primer dan sekunder. Metode analisis data menggunakan rumus pendapatan  π  =  TR – TC dan rumus kelayakan R/C ratio dan untuk mengetahui pola pemasaran karet rakyat dilakukan secara deskriptif yaitu hanya melihat pola pemasaran yang terjadi di Kelurahan Simangambat Kecamatan Siabu Kabupaten Mandailing Natal. Hasil penelitian menunjukkan bahwa keuntungan petani karet rakyat di daerah penelitian sebesar Rp. 56.475.766  /tahun.Usahatani karet rakyat  layak untuk diusahakan di daerah penelitian dikarenakan nilai R/C Rasio yang di peroleh lebih besar dari satu (R/C Rasio > 1). Dengan nilai 4,81> 1, maka dikatakan bahwa usahatani karet rakyat layak di usahakan di  Kelurahan Simangambat  Kecamatan Siabu Kabupaten Mandailing Natal, walaupun dengan keterbatasan modal yang dimiliki petani akibat menurunnya  harga karet yang cukup drastis.Rantai pemasaran karet rakyat di daerah penelitian Petani                  menjual karetnya ke Pedagang Pengumpul Desa (Agen) dan selanjutnya menjualnya ke Pabrik Industri pengolahan karet
Pengawasan Perlindungan Hukum dalam Pemenuhan Hak Tenaga Kerja Akibat Kecelakaan Kerja Di Kabupaten Magelang
Authors: Prabowo Wahyu , Suwandoko Suwandoko , Radityawati Rena
Published: June 2023

Kecelakaan Kerja adalah kecelakaan yang terjadi dalam hubungan kerja, termasuk kecelakaan selama perjalanan dari rumah menuju tempat kerja atau sebaliknya. Di Kabupaten Magelang tercatat sebanyak 2037 kasus kecelakaan kerja pada tahun 2021. Pasal 176 Undang-Undang Nomor 13 Tahun 2003 tentang Ketenagakerjaan yang menyatakan pengawasan ketenagakerjaan dilakukan oleh pegawai pengawas ketenagakerjaan yang mempunyai kompetensi independen guna menjamin pelaksanaan peraturan perundang-undangan. Tujuan dari penelitian untuk menganalisa pentingnya pengawasan ketenagakerjaan dan model implementasi pengawasan perlindungan hukum dalam pemenuhan hak tenaga kerja akibat kecelakaan kerja di Kabupaten Magelang. Diharapkan penelitian ini dapat memberikan sumbangan pengetahuan dalam ilmu pengetahuan khususnya pada hukum ketenagakerjaan. Penelitian ini merupakan penelitian yuridis empiris, fokus penelitian terletak pada pengawaan perlindungan hukum terhadap tenaga kerja yang mengalami kecelakaan kerja di Kabupaten Magelang. Pengumpulan data dilakukan dengan studi kepustakaan dan studi lapangan (wawancara). Teknik analisis data yang digunakan adalah metode kualitatif. Hasil penelitian menunjukkan alasan diperlukannya pengawasan ketenagakerjaan dengan landasan filosofis, yuridis dan sosilogis karena merupakan hal penting yang dilakukan pemerintah bersama perusahaan guna memperoleh perlindungan hukum dan upaya penegakan hukum ketenagakerjaan. Hambatan minimnya jumlah pegawai pengawas, kurangnya sarana dan prasarana, dan K3 di perusahaan. Upaya pencegahannya kerja dengan perbaikan sistem management, meningkatkan sarana dan prasarana, dan mengoptimalkan K3 di perusahaan.