bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive Evaluation of Quality Characteristics of Four Oil-Tea Camellia Species with Red Flowers and Large Fruit
Authors: Zhong Shengyue , Huang Bin , Wei Teng , Deng Zeyuan , Li Jing , Wen Qiang
Published: January 2023

Red-flowered oil-tea camellia (ROC) is an important woody oil species growing in the south, and its oil has high nutritional value. There are four main species of ROC in China, namely, Camellia chekiangoleosa (CCH), Camellia polyodonta (CPO), Camellia semiserrata (CSE) and Camellia reticulata (CRE). Reports on the comprehensive comparative analysis of ROC are limited. This study investigated the fruit characteristics and nutritional components of four ROC fruits, and the results showed that ROC had high oil content with levels of 39.13%–58.84%, especially the CCH fruit, which reached 53.6–58.84%. The contents of lipid concomitants of ROC oil were also substantial, including β-amyrin (0.87 mg/g–1.41 mg/g), squalene (0.43 mg/g–0.69 mg/g), β-sitosterin (0.47 mg/g–0.63 mg/g) and α-tocopherol (177.52 μg/g–352.27 μg/g). Moreover, the transverse diameter(TD)/longitudinal diameter (LD) of fruits showed a significant positive correlation with the oil content, and ROC fruits with thinner peels seemed to have better oil quality, which is similar to the result of the oil quality evaluation obtained by the gray correlation coefficient evaluation method. Four ROC oils were evaluated using the gray correlation coefficient method based on 11 indicators related to the nutritional value of ROC. CCH oil had the highest score of 0.8365, and YS-2 (a clone of CCH) was further evaluated as the best CCH oil. Finally, the results of heatmap analysis showed that triglycerides could be used as a characteristic substance to distinguish CCH oil from the other three ROC oils. The PLSDA (Partial least squares regression analysis) model and VIP (Variable important in projection) values further showed that P/S/O, P/O/O, P/L/L, P/L/Ln, S/S/O, S/O/O and P/S/S (these all represent abbreviations for fatty acids) could be used as characteristic differential triglycerides among the four ROC oils. This study provides a convenient way for planters to assess the nutritional quality of seed oil depending on fruit morphology and a potential way to distinguish between various ROC oils.
Efficient Biodegradation of Patulin by Aspergillus niger FS10 and Metabolic Response of Degrading Strain
Authors: Yang Yang , Ji Jian , Wu Shang , Ye Yongli , Sheng Lina , Zhang Yinzhi , Sun Xiulan
Published: January 2023

Patulin, a mycotoxin commonly found in fruits and derived products, causes serious health problems for humans and animals worldwide. Several microbial strains have been observed to possess the ability to effectively remove patulin. However, these methods are presently associated with disadvantages such as low degradation efficiency and an unclear biodegradation mechanism. In the current study, the characteristics of patulin degradation via Aspergillus niger FS10 were evaluated, and the mechanisms involved were analyzed using metabolomics technologies. The results showed that the suspension of A. niger FS10 could degrade 94.72% of patulin within 36 h. The moment concentration pf patulin was 0.116 μg/mL, and the detection limit value was 0.01 μg/mL. In addition, the patulin content was reduced to levels below the detection limit within 48 h. A. niger FS10 mainly degrades patulin by producing intracellular enzymes, which can convert patulin into ascladiol. This degradation method can effectively reduce the damage caused by patulin to HepG2 cells. In addition, the patulin treatment significantly affects the pentose phosphate pathway and the glutathione pathway. These two metabolic pathways are speculated to be closely related to patulin degradation via A. niger FS10. The incubation of A. niger FS10 with patulin-contaminated apple pomace can not only eliminate patulin but also increase the utilization of apple pomace. Therefore, our research results provide a new method for addressing patulin contamination in the food and feed industries.
Effects of Cheonggukjang (Fermented Soybean) on the Development of Colitis-Associated Colorectal Cancer in Mice
Authors: Lim Hyeon-Ji , Park In-Sun , Jeong Su-Ji , Ha Gwang-Su , Yang Hee-Jong , Jeong Do-Youn , Kim Seon-Young , Jung Chan-Hun
Published: January 2023

Colorectal cancer (CRC) is the third most common type of cancer and is caused by multiple factors. Chronic inflammation, known to cause inflammatory bowel disease (IBD), is closely associated with CRC. Cheonggukjang (CJ), a traditional Korean fermented soybean, is a functional food with anti-inflammatory effects in the intestines, but its anti-cancer effects have not yet been explored. In this study, we investigated the cancer-protective effects of cheonggukjang in an azoxymethane/DSS (AOM/DSS)-induced colitis-associated colorectal cancer (CAC) mouse model. The CJ alleviated AOM/DSS-induced pathological symptoms such as colonic shortening, increased spleen weight, tumor formation, and histological changes. It also modulated pro-inflammatory and anti-inflammatory cytokine levels via the suppression of NF-κB and inflammatory mediator signaling pathways. Furthermore, the CJ improved intestinal integrity by regulating mucin-associated and tight junction proteins. In addition, it suppressed tumor growth by regulating apoptosis and proliferation. These results highlight the anti-tumor effects of CJ in an AOM/DSS-induced CAC mouse model.
Fractional Stochastic Integro-Differential Equations with Nonintantaneous Impulses: Existence, Approximate Controllability and Stochastic Iterative Learning Control
Authors: Abuasbeh Kinda , Mahmudov Nazim I. , Awadalla Muath
Published: January 2023

In this paper, existence/uniqueness of solutions and approximate controllability concept for Caputo type stochastic fractional integro-differential equations (SFIDE) in a Hilbert space with a noninstantaneous impulsive effect are studied. In addition, we study different types of stochastic iterative learning control for SFIDEs with noninstantaneous impulses in Hilbert spaces. Finally, examples are given to support the obtained results.
An ε-Approximate Approach for Solving Variable-Order Fractional Differential Equations
Authors: Wang Yahong , Wang Wenmin , Mei Liangcai , Lin Yingzhen , Sun Hongbo
Published: January 2023

As a mathematical tool, variable-order (VO) fractional calculus (FC) was developed rapidly in the engineering field due to it better describing the anomalous diffusion problems in engineering; thus, the research of the solutions of VO fractional differential equations (FDEs) has become a hot topic for the FC community. In this paper, we propose an effective numerical method, named as the ε-approximate approach, based on the least squares theory and the idea of residuals, for the solutions of VO-FDEs and VO fractional integro-differential equations (VO-FIDEs). First, the VO-FDEs and VO-FIDEs are considered to be analyzed in appropriate Sobolev spaces H2n[0,1] and the corresponding orthonormal bases are constructed based on scale functions. Then, the space H2,02[0,1] is chosen which is just suitable for one of the models the authors want to solve to demonstrate the algorithm. Next, the numerical scheme is given, and the stability and convergence are discussed. Finally, four examples with different characteristics are shown, which reflect the accuracy, effectiveness, and wide application of the algorithm.
Acknowledgment to the Reviewers of Future Transportation in 2022
Authors:   Future Transportation Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Genetic and Molecular Interactions between HΔCT, a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster
Authors: Maier Dieter , Bauer Milena , Boger Mike , Sanchez Jimenez Anna , Yuan Zhenyu , Fechner Johannes , Scharpf Janika , Kovall Rhett A. , Preiss Anette , Nagel Anja C.
Published: January 2023

Cellular differentiation relies on the highly conserved Notch signaling pathway. Notch activity induces gene expression changes that are highly sensitive to chromatin landscape. We address Notch gene regulation using Drosophila as a model, focusing on the genetic and molecular interactions between the Notch antagonist Hairless and the histone chaperone Asf1. Earlier work implied that Asf1 promotes the silencing of Notch target genes via Hairless (H). Here, we generate a novel HΔCT allele by genome engineering. Phenotypically, HΔCT behaves as a Hairless gain of function allele in several developmental contexts, indicating that the conserved CT domain of H has an attenuator role under native biological contexts. Using several independent methods to assay protein–protein interactions, we define the sequences of the CT domain that are involved in Hairless–Asf1 binding. Based on previous models, where Asf1 promotes Notch repression via Hairless, a loss of Asf1 binding should reduce Hairless repressive activity. However, tissue-specific Asf1 overexpression phenotypes are increased, not rescued, in the HΔCT background. Counterintuitively, Hairless protein binding mitigates the repressive activity of Asf1 in the context of eye development. These findings highlight the complex connections of Notch repressors and chromatin modulators during Notch target-gene regulation and open the avenue for further investigations.
Antioxidant-Enriched Diet on Oxidative Stress and Inflammation Gene Expression: A Randomized Controlled Trial
Authors: Gualtieri Paola , Marchetti Marco , Frank Giulia , Smeriglio Antonella , Trombetta Domenico , Colica Carmela , Cianci Rossella , De Lorenzo Antonino , Di Renzo Laura
Published: January 2023

The Mediterranean Diet (MedDiet) is associated with beneficial effects against chronic non-communicable diseases (CNCDs). In particular, the content of micronutrients leads to an improvement of the oxidative and inflammatory profiles. A randomized, parallel, controlled study, on 24 subjects, was conducted to evaluate if 2-week supplementation with a mixed apple and bergamot juice (MAB juice), had a positive impact on the body composition, the biochemical profile, and oxidative and inflammatory gene expression (Superoxide dismutase (SOD1), Peroxisome Proliferator-Activated Receptor γ (PPARγ), catalase (CAT), chemokine C-C motif ligand 5 (CCL5), Nuclear Factor Kappa B Subunit 1 (NFKB1), Vitamin D Receptor (VDR), and Macrophage Migration Inhibitory Factor (MIF)), respect to a MedDiet. Body composition evaluation analysis showed a gain in lean mass (p < 0.01). Moreover, a significant reduction in total cholesterol/HDL index (p < 0.01) was pointed out between the two groups. Gene expression analysis highlighted an increase in MIF (p ≤ 0.05), PPARγ (p < 0.001), SOD1 (p ≤ 0.05), and VDR (p ≤ 0.05) expressions when comparing MedDiet and MedDiet + MAB juice groups. These data based on the nutrigenomics approach demonstrated that supplementing 2 weeks of MAB juice to the MedDiet could contribute to a reduction in the risk of CNCDs.
Acknowledgment to the Reviewers of Geomatics in 2022
Authors:   Geomatics Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Seepage-Induced Pore Pressure Variations Beneath an Earthen Levee Measured with a Novel Seismic Tool
Authors: Locci-Lopez Daniel , Lorenzo Juan M.
Published: January 2023

Shear-wave seismic reflection velocity-versus-depth models can complement our understanding of seepage pore pressure variations beneath earthen levees at locations between geotechnical sites. The seasonal variations of water level in the Mississippi River create pore pressure changes in the adjacent hydraulically connected aquifer on the protected side of artificial levees. Time-lapse shear-wave velocity analysis or repetition of seismic acquisition over an area is a non-invasive method that can detect seasonal pore pressure variations in shallow (<40 m) aquifers. The seismic reflection patterns during the seasonal pore pressure variations of the river show a distinctive change in the velocity semblance analysis, which is translated as a change in the average stress carried by the grain-to-grain contact, or simply the effective pressure. The seismic data show a greater variation of up to +140/−40 m/s or +700/−150 kPa in the confined aquifer zone, compared with the leaky confined aquifer zone of up to +46/−48 m/s or +140/−80 kPa. These relative effective pressure characteristics allow us to distinguish between confined and leaky aquifers and can be an optional approach for pressure prediction in floodplains along levees without the need to drill borings in the area to measure piezometric data.
Prevalence of Precancerous Cervical Lesions among Nonvaccinated Kazakhstani Women: The National Tertiary Care Hospital Screening Data (2018)
Authors: Imankulova Balkenzhe , Babi Aisha , Issa Torgyn , Zhumakanova Zhanar , Knaub Ljubov , Yerzhankyzy Aidana , Aimagambetova Gulzhanat
Published: January 2023

Objective: At the present time, cervical cancer remains the fourth most prevalent cancer among women worldwide. Most cervical cancer cases are attributed to high-risk human papillomavirus (HPV) infection. Because the natural history of cervical cancer takes decades, the disease could be prevented if premalignant conditions are identified and appropriately managed. The aim of this study is to identify the prevalence of precancerous lesions among non-vaccinated women attending the national tertiary care hospital in Kazakhstan. Methods: This was a retrospective study of the cervical cancer screening database (2018) from the national tertiary care hospital in Kazakhstan. Records of 6682 patients, who had cervical cytology tests by Papanicolaou (Pap test), were analyzed. Out of the revised cases, 249 patients had abnormal cervical cytology reports. The Pap test was performed using liquid-based cytology (LBC). The data were analyzed using the statistical software STATA 16. A p-value of less than 0.05 was considered statistically significant. Results: In this retrospective analysis of 6682 patients’ records, we found 3.73% (249 patients) out of all Pap tests performed in 2018 were abnormal. The prevalence of high-grade squamous intraepithelial lesion (HSIL) was high at 19.28%, and the proportion of atypical squamous cells of undetermined significance (ASCUS) and atypical squamous cells (ASCs-H) was 18.47%, while low-grade squamous intraepithelial lesion (LSIL) were identified in 62.25% of the cases. Almost 25% of the women included in the study had concurrent lower and upper genital tract infections. Conclusion: Although the overall rate of abnormal Pap test results was not high, the study shows the elevated prevalence of HSIL. It calls the attention of local policymakers and gynecology specialists and requires immediate actions to improve the prophylactic measures to decrease morbidity and mortality from cervical cancer in Kazakhstan.
Chronic Training Induces Metabolic and Proteomic Response in Male and Female Basketball Players: Salivary Modifications during In-Season Training Programs
Authors: Luti Simone , Militello Rosamaria , Pinto Gabriella , Illiano Anna , Amoresano Angela , Chiappetta Giovanni , Marzocchini Riccardo , Modesti Pietro Amedeo , Pratesi Simone , Pazzagli Luigia , Modesti Alessandra , Gamberi Tania
Published: January 2023

The aim of this study was to characterize the salivary proteome and metabolome of highly trained female and male young basketball players, highlighting common and different traits. A total of 20 male and female basketball players (10 female and 10 male) and 20 sedentary control subjects (10 female and 10 male) were included in the study. The athletes exercised at least five times per week for 2 h per day. Saliva samples were collected mid-season, between 9:00 and 11:00 a.m. and away from sport competition. The proteome and metabolome were analyzed by using 2DE and GC–MS techniques, respectively. A computerized 2DE gel image analysis revealed 43 spots that varied in intensity among groups. Between these spots, 10 (23.2%) were differentially expressed among male athletes and controls, 22 (51.2%) between female basketball players and controls, 11 spots (25.6%) between male and female athletes, and 13 spots (30.2%) between male and female controls. Among the proteins identified were Immunoglobulin, Alpha-Amylase, and Dermcidin, which are inflammation-related proteins. In addition, several amino acids, such as glutamic acid, lysine, ornithine, glycine, tyrosine, threonine, and valine, were increased in trained athletes. In this study, we highlight that saliva is a useful biofluid to assess athlete performance and confirm that the adaptation of men and women to exercise has some common features, but also some different sex-specific behaviors, including differential amino acid utilization and expression of inflammation-related proteins, which need to be further investigated. Moreover, in the future, it will be interesting to examine the influence of sport-type on these differences.
Healthcare Waste—A Serious Problem for Global Health
Authors: Janik-Karpinska Edyta , Brancaleoni Rachele , Niemcewicz Marcin , Wojtas Wiktor , Foco Maurizio , Podogrocki Marcin , Bijak Michal
Published: January 2023

Healthcare waste (HCW) is generated in different healthcare facilities (HCFs), such as hospitals, laboratories, veterinary clinics, research centres and nursing homes. It has been assessed that the majority of medical waste does not pose a risk to humans. It is estimated that 15% of the total amount of produced HCW is hazardous and can be infectious, toxic or radioactive. Hazardous waste is a special type of waste which, if not properly treated, can pose a risk to human health and to the environment. HCW contains potentially harmful microorganisms that can be spread among healthcare personnel, hospital patients and the general public, causing serious illnesses. Healthcare personnel are the specialists especially exposed to this risk. The most common medical procedure, which pose the highest risk, is injection (i.e, intramuscular, subcutaneous, intravenous, taking blood samples). The World Health Organization (WHO) estimates that around 16 billion injections are administered worldwide each year. However, if safety precautions are not followed, and needles and syringes are not properly disposed of, the risk of sharps injuries increases among medical staff, waste handlers and waste collectors. What is more, sharps injuries increase the risk of human immunodeficiency virus (HIV), hepatitis B and C viruses (HBV/HCV), tuberculosis (TB), diphtheria, malaria, syphilis, brucellosis and other transmissions. Disposing of medical waste in a landfill without segregation and processing will result in the entry of harmful microorganisms, chemicals or pharmaceuticals into soil and groundwater, causing their contamination. Open burning or incinerator malfunctioning will result in the emission of toxic substances, such as dioxins and furans, into the air. In order to reduce the negative impact of medical waste, waste management principles should be formulated. To minimize health risks, it is also important to build awareness among health professionals and the general public through various communication and educational methods. The aim of this paper is to present a general overwiev of medical waste, its categories, the principles of its management and the risks to human health and the environment resulting from inappropriate waste management.
Domestication of Wild Edible Species: The Response of Scolymus hispanicus Plants to Different Fertigation Regimes
Authors: Paschoalinotto Beatriz H. , Polyzos Nikolaos , Compocholi Maria , Rouphael Youssef , Alexopoulos Alexios , Dias Maria Inês , Barros Lillian , Petropoulos Spyridon A.
Published: January 2023

Scolymus hispanicus L. is a wild edible species with wide distribution in the Mediterranean area. Recent research has focused on the domestication of wild edible greens, which is essential for the preservation of agroecosystems and the increase in biodiversity, especially under the adversely changing climate conditions. In the present work, the aim was to evaluate the response of S. hispanicus plants to different fertilization regimes that varied in the amounts of nitrogen, phosphorus and potassium in regard to plant growth and chemical composition of leaves. For this purpose, plants were grown in pots within an unheated greenhouse. Seven experimental treatments were used, including six fertigation regimes (SH1-SH6) and the control treatment (SHC), where no fertilizers were added. Fresh yield was beneficially affected by the treatments that included a high content of P and K (e.g., SH3 and SH5), while lesser amounts of these macronutrients (e.g., SH1 and SH4) resulted in higher chlorophyll content (SPAD index) and leaf area. In terms of mineral profile, high amounts of P and K improved dietary fiber and carbohydrates content, whereas the untreated plants had the highest content of ash, fat and crude protein. Oxalic and quinic acid were the major organic acids detected, with fertigation regimes significantly reducing their content compared to the control treatment. α-tocopherol was the only isoform of vitamin E detected in all the samples, while glucose and fructose were the most abundant sugars, with their highest content detected in control and SH4 treatments, respectively. Scolymus hispanicus leaves were rich in macro and micro minerals, while their contents varied depending on the fertigation regime. Finally, α-linolenic, palmitic, and linoleic acid were the major fatty acids detected, while their contents were beneficially affected by low nutrient inputs (e.g., untreated plants and SH1 and SH2 treatments). In conclusion, the regulation of nutrient solution seems to be an effective practice to increase fresh yield in S. hispanicus without compromising the nutritional profile of the edible product, while low inputs of macronutrients such as P and K may improve the chemical composition of the species, especially in terms of n-fatty acids.
The Association of Maternal BMI with Overweight among Children Aged 0–59 Months in Kenya: A Nationwide Cross-Sectional Study
Authors: Mulu Amos , Neupane Subas
Published: January 2023

Childhood overweight is a growing global public health challenge and is prevalent in many countries. We aimed at exploring the prevalence of childhood overweight and the association of maternal body mass index (BMI), maternal demographic factors, and child-related factors with childhood overweight among Kenyan children aged 0-59 months. This study utilized Kenya’s 2014 demographic and health survey, which was based on national representative cross-sectional data. A total of 8316 children and their mothers’ data were analyzed. Overweight in children and maternal BMI were defined using WHO standard criteria. Multivariate logistics regression models were used to study the association of maternal BMI and childhood overweight. Nationally 5% of Kenyan children aged 0–59 months are overweight (5.5% male vs. 3.8% female). The highest prevalence in overweight among children was found in Central region (6.9%) and lowest in North Eastern (3.1%) which could be explained by the various economic disparities. Maternal BMI with underweight was associated with lower odds (OR 0.30, 95% CI 0.14–0.64) whereas, overweight and obesity were associated with higher odds of overweight (OR for overweight 1.64, 95% CI 1.28–2.11 and OR for obesity 1.74, 95% CI 1.22–2.47) among their children compared to normal weight mothers. Overweight among children is of great concern and therefore initiatives to tackle both child and maternal health are urgently needed.
Healthcare Costs and Health Status: Insights from the SHARE Survey
Authors: Cygańska Małgorzata , Kludacz-Alessandri Magdalena , Pyke Chris
Published: January 2023

The substantial rise in hospital costs over recent years is associated with the rapid increase in the older age population. This study addresses an empirical gap in the literature concerning the determinants of high hospital costs in a group of older patients in Europe. The objective of the study is to examine the association of patient health status with in-hospital costs among older people across European countries. We used the data from the Survey of Health, Ageing and Retirement in Europe (SHARE) database. The analysis included 9671 patients from 18 European countries. We considered socio-demographic, lifestyle and clinical variables as possible factors influencing in-hospital costs. Univariate and multivariable logistic regression analyses were used to determine the determinants of in-hospital costs. To benchmark the hospital costs across European countries, we used the cost-outlier methodology. Rates of hospital cost outliers among older people varies from 5.80 to 12.65% across Europe. Factors associated with extremely high in-patient costs differ among European countries. In most countries, they include the length of stay in the hospital, comorbidities, functional mobility and physical activity. The treatment of older people reporting heart attack, diabetes, chronic lung disease and cancer are more often connected with cost outliers. The risk of being a cost outlier increased by 20% with each day spent in the hospital. We advocate that including patient characteristics in the reimbursement system could provide a relatively simple strategy for reducing hospitals’ financial risk connected with exceptionally costly cases.
Modelling Impact of High-Rise, High-Density Built Environment on COVID-19 Risks: Empirical Results from a Case Study of Two Chinese Cities
Authors: Xu Yong , Guo Chunlan , Yang Jinxin , Yuan Zhenjie , Ho Hung Chak
Published: January 2023

Characteristics of the urban environment (e.g., building density and road network) can influence the spread and transmission of coronavirus disease 2019 (COVID-19) within cities, especially in high-density high-rise built environments. Therefore, it is necessary to identify the key attributes of high-density high-rise built environments to enhance modelling of the spread of COVID-19. To this end, case studies for testing attributes for modelling development were performed in two densely populated Chinese cities with high-rise, high-density built environments (Hong Kong and Shanghai).The investigated urban environmental features included 2D and 3D urban morphological indices (e.g., sky view factor, floor area ratio, frontal area density, height to width ratio, and building coverage ratio), socioeconomic and demographic attributes (e.g., population), and public service points-of-interest (e.g., bus stations and clinics). The modelling effects of 3D urban morphological features on the infection rate are notable in urban communities. As the spatial scale becomes larger, the modelling effect of 2D built environment factors (e.g., building coverage ratio) on the infection rate becomes more notable. The influence of several key factors (e.g., the building coverage ratio and population density) at different scales can be considered when modelling the infection risk in urban communities. The findings of this study clarify how attributes of built environments can be applied to predict the spread of infectious diseases. This knowledge can be used to develop effective planning strategies to prevent and control epidemics and ensure healthy cities.
The Serum Levels of the Heavy Metals Cu, Zn, Cd, and Pb and Progression of COPD—A Preliminary Study
Authors: Valkova Elica , Atanasov Vasil , Vlaykova Tatyana , Tacheva Tanya , Zhelyazkova Yanitsa , Dimov Dimo , Yakimov Kristian
Published: January 2023

There is evidence in previous studies that high levels of heavy metals may play a key role in the development of COPD due to the induction of chronic inflammation and oxidative stress. In this preliminary study, we used atomic absorption spectrophotometry to measure the levels of four heavy metals (Cu, Zn, Cd, and Pb) in blood serum of COPD patients and controls over 2 years. Clinical data on disease progression or absence were collected in patients living in the industrial region of Stara Zagora, Bulgaria. The mean values of Cu in the serum of patients with COPD and the control group were 374.29 ± 15.03 μg/L and 238.55 ± 175.31 μg/L, Zn—2010.435 ± 670.006 μg/L and 1672.78 ± 934.27 μg/L, Cd—0.334 ± 0.0216 μg/L and 0.395 ± 0.110 μg/L and Pb—0.0732 ± 0.009 μg/L and 0.075 ± 0.0153 μg/L. This is probably because these elements are biogenic and are used in the body for its anti-oxidant protection. In fact, it cannot be stated with certainty that elevated levels of Cu and Zn in the environment have a negative impact in COPD patients. There was a trend towards higher levels of the toxicants lead and cadmium in COPD patients compared to the control group of patients. There is a statistically unproven trend toward higher levels of lead and cadmium in COPD patients compared to controls, which to some extent supports our hypothesis that there is a relationship between environmental lead and cadmium levels and the COPD manifested. In COPD patients, a positive correlation was found between BMI and serum Cu levels (r = 0.413, p = 0.005). A higher concentration of serum Cu was found in men with BMI ≥ 30, compared to those with BMI < 30. There is also a positive correlation to a lesser extent between CRP and cadmium (r = 0.380; p = 0.019) and lead (r = 0.452; p = 0.004). The correlation of lead and cadmium with PSA also shows that these elements may also be associated with the presence of inflammatory processes. A significant negative correlation exists between Pb in the serum of patients with COPD and their blood hemoglobin (r = −356; p = 0.028). The results of our study suggest that higher doses of the trace elements Cu and Zn do not always have a negative effect in patients with COPD, while the toxicants Pb and Cd may be involved in COPD exacerbation and can be used as prognostic biomarkers for progression. Further studies are warranted to confirm these preliminary results.
Energy Consumption Structure and Influencing Factors of Farmers in China from the Perspective of Labor Transfer
Authors: Wu Jiaojiao , Qing Chen , Zhou Wenfeng , Guo Shili , Xu Dingde
Published: January 2023

Under the background of carbon peak and carbon neutralization, the transformation and upgrading of energy consumption structure is crucial to achieve sustainable environmental development. Based on the questionnaire data of 1080 farmers in Sichuan province in 2021, the IV-Probit model was used to explore the impact of labor from off-farm employment on farmers’ energy consumption structure and its specific mechanism. The results show the following: (1) the overall proportion of off-farm employment is not high, only 23%; in cooking energy, the most farmers use high-quality energy, accounting for up to 94%; (2) in addition to high-quality energy, off-farm employment of labor force is positively and significantly correlated with the remaining six types of energy consumption structure. The results of a heterogeneity analysis show that the proportion of off-farm employment of farmers with a high education level and above has the greatest positive effect on the use of high-quality energy; (3) the results of the mediating effect show that the off-farm employment can affect the energy consumption structure of farmers through the two paths of annual cash income and population structure.
A Systematic Review of Mobile Apps as an Adjunct to Psychological Interventions for Emotion Dysregulation
Authors: Diano Federico , Sica Luigia Simona , Ponticorvo Michela
Published: January 2023

Background: Mental health care has been enriched with the progressive use of technology during the last ten years, in particular after the COVID-19 pandemic. Mobile applications (apps) and smartphones have become the most widespread access point for many people who look for self-help in the psychological domain. Objective: We focused on a systematic review of mobile apps for mental health, focusing on the blending of apps with psychotherapy contexts, with a specific focus on emotional dysregulation. Methods: A comprehensive literature search (January 2017 to August 2022) in PubMed, PsycInfo, Web of Science, and the Cochrane Library was conducted. Abstracts were included if they described mental health mobile apps targeting emotional dysregulation and their use during ongoing psychological or psychotherapy treatment for adults and adolescents. Results: In total, 397 abstracts were identified; of these, 19 publications describing apps targeting borderline personality disorder, depression, anxiety, suicidal behaviors, and post-traumatic stress disorders met the inclusion criteria. Conclusions: App-enhanced psychotherapy might be a winning combination in many scenarios, but at the same time, many issues must still be faced in this yet emerging scientific field. In conclusion, we tried to put together some major guidelines for mental health mobile app development in the context of psychological treatments.
Factors Associated with Insomnia and Aggression among Healthcare Workers during COVID-19 Pandemic
Authors: Cybulska Anna Maria , Weymann Agnieszka , Rachubińska Kamila , Grochans Szymon , Wójcik Grzegorz , Grochans Elżbieta
Published: January 2023

(1) Healthcare workers are exposed to increased risks of insomnia and aggression during the COVID-19 pandemic. The aim of the study was to assess insomnia, sleep disturbances, and aggression and identify the associated risk factors among healthcare workers during the COVID-19 pandemic. (2) A total of 264 healthcare workers participated in the study. The study was conducted with the diagnostic survey method, using the Buss–Perry Aggression Questionnaire, the Athens Insomnia Scale, the Pittsburgh Sleep Quality Index, and a self-administered questionnaire. (3) The vast majority of the respondents (81.06%) suffered from insomnia and had poor sleep quality (78.03%). Education (p = 0.038), marital status (p = 0.043), and working with patients suffering from COVID-19 (p = 0.024) were statistically significant contributors to insomnia. Age was found to significantly correlate with total aggression (r = −0.133 p = 0.031), verbal aggression (r = −0.138 p = 0.025), and anger (r = −0.151 p = 0.014). The analysis demonstrated statistically significant relationships between gender and physical aggression (p = 0.017), anger (p = 0.032), and hostility (p = 0.002). A statistically significant positive correlation between the quality of sleep as per the PSQI and all subscales of the BPAQ was found (p < 0.001). (4) A considerable proportion of HCWs experienced sleep disturbances during the outbreak, stressing the need to establish ways to reduce long-term adverse outcomes associated with chronic insomnia and mental health problems and adjust interventions under pandemic conditions.
Three-Dimensional Assessment of Temporomandibular Joint Morphology and Facial Asymmetry in Individuals with Different Vertical Skeletal Growth Patterns
Authors: Diwakar Rohan , Bucci Rosaria , Kaushik Ankur , Bansal Anubhav , Bucci Paolo , Kochhar Anuraj Singh , Spagnuolo Gianrico
Published: January 2023

The aim of the current study was to investigate, by means of Cone-Beam Computed Tomography (CBCT), condyle–fossa relationship, temporomandibular joint (TMJ) morphology and facial asymmetry in subjects with different vertical skeletal growth patterns. CBCT of 56 patients (112 TMJs) were categorized into three groups according to the mandibular plane angle (MP): Hypodivergent (MP ≤ 23°), Normodivergent (23° < MP < 30°), and Hyperdivergent (MP ≥ 30°). TMJ spaces, width and depth of the condyle and thickness of the fossa were measured. Horizontal and vertical measurements were used to assess facial asymmetry. One-way Analysis of Variance (ANOVA) and post-hoc Turkey tests were computed for the between-groups comparison. Statistical significance was set at p < 0.05. Larger anterior joint space and smaller condylar dimensions (medio-lateral diameter and medio-lateral thickness) were observed in the hyperdivergent group compared to the normodivergent and hypodivergent groups. Right condylar distances to midsagittal plane were significantly larger than left distances in all the three groups. A vertical pattern of growth in healthy individuals seems to be associated with condylar position and dimension, while facial asymmetry values do not differ among different vertical groups.
For Children or Grandchildren?—The Motivation of Intergenerational Care for the Elderly in China
Authors: Luo Juan , Cui Mengmeng
Published: January 2023

Considering our aging society and declining birthrate, we studied the motivations for intergenerational care for the elderly in China and analyze it through different generations of children and grandchildren. This paper mainly uses logistic regression analysis, descriptive statistics, heterogeneity analysis, robustness analysis, and other quantitative methods to analyze the data of the China Household Tracking Survey (CFPS) in 2018. According to the relevant research results, we believe that both children or grandchildren may be motivations. However, the proportion of factors is higher because the proportion of parents choosing alternate-generation care has increased based on the financial support provided by their children, and underdeveloped children are more likely to be favored by their parents to provide alternate-generation care. This paper is more inclined to consider children to be the main motivator for intergenerational care under the dual motives of “feedback” exchange and altruism through “helping the weak”. Next, the influence factors of a series of control variables are analyzed for the groups that take care of the next generation, and it is found that the intimacy between the elderly and their spouses, the number of meals with their families per week, and the use of electronic products will all affect the degree of care provided by their fathers. Based on this, this paper proposes that the three forces of government, society, and family are needed for joint support of the elderly when they are taking care of each other. We will make generational care less responsible, free and burdensome, and at the same time respect the right of the elderly to say “no” to providing care.
Investigating the Potential of Transparent Parallel-Arranged Micro-Perforated Panels (MPPs) as Sound Absorbers in Classrooms
Authors: Fasllija Ela , Yilmazer Semiha
Published: January 2023

Acoustic deficiencies due to lack of absorption in indoor spaces may sometime render significant buildings unfit for their purpose, especially the ones used as speech auditoria. This study investigates the potential of designing wideband acoustic absorbers composed of parallel-arranged micro-perforated panels (MPPs), known as efficient absorbers that do not need any other fibrous/porous material to have a high absorptive performance. It aims to integrate architectural trends such as transparency and the use of raw materials with acoustical constraints to ensure optimal indoor acoustic conditions. It proposes a structure composed of four parallel-arranged MPPs, which have been theoretically modelled using the electrical Equivalent Circuit Model (ECM) and implemented on an acrylic prototype using recent techniques such as CNC machining tools. The resulting samples are experimentally analysed for their absorption efficiency through the ISO-10534-2 method in an impedance tube. The results show that the prediction model and the experimental data are in good agreement. Afterward, the investigation focuses on applying the most absorptive MPP structure in a classroom without acoustic treatment through numerical simulations in ODEON 16 Acoustics Software. When the proposed material is installed as a wall panel, the results show an improvement toward optimum values in Reverberation Time (RT30) and Speech Transmission Index (STI).
Virtual Training on Stress Management for the Mothers of Children with Disabilities in the United Arab Emirates
Authors: Abdat Rawhi , Opoku Maxwell Peprah , Safi Mohammed , Al Harballeh Siham , Garces-Bacsal Rhoda Myra
Published: January 2023

Parenting children with disabilities has consistently been reported to be associated with stress, and even more so among mothers who are primary caregivers. In non-Western contexts such as the United Arab Emirates (UAE), there is a dearth of research on maternal mental health in relation to raising children with disabilities and related mitigation strategies. During the COVID-19 pandemic (2020–2021), the Federal Government of the UAE used the Save the Child’s Stress Checklist to assess the stress levels of 635 mothers who were raising children with disabilities in the northern part of the country. In the pre-test, an estimated 6% (36/635) of the mothers were found to be experiencing high levels of stress. Consequently, virtual stress management training was conducted, and 12 of the 36 mothers completed the full training. Wilcoxon’s ranked test showed a reduction in their total, physical, emotional and cognitive stress at the end of the training. This study demonstrates the pressing need for ongoing training programmes to improve the mental health of mothers of children with disabilities in the UAE and similar contexts.
Group Nature-Based Mindfulness Interventions: Nature-Based Mindfulness Training for College Students with Anxiety
Authors: Vitagliano Luke A. , Wester Kelly L. , Jones Connie T. , Wyrick David L. , Vermeesch Amber L.
Published: January 2023

The mental health crisis across college campuses is accelerating, with anxiety listed as the top mental health issue for undergraduate college students. Although evidence suggests the COVID-19 pandemic escalated the mental health crisis on college campuses, pre-COVID-19 anxiety among college students was on the rise. Research supports Mindfulness Based Interventions (MBIs) to reduce anxiety among college students. Additionally, exposure to natural environments, which are accessible to students on college campuses, is effective in reducing anxiety. While brief nature-based mindfulness interventions appear effective in reducing anxiety among college students, these interventions are often offered in isolation without social interaction among group members and lack intentional integration of mindfulness and nature-related theories. The purpose of this work is to describe a framework for integrating the use of Mindfulness and Attention Restoration Theory (ART) in an innovative psychoeducational group intervention, Nature-Based Mindfulness Training © (NBMT), for college students with anxiety. In conclusion, we argue for the need to intentionally integrate mindfulness and nature into nature-based mindfulness interventions as an effective and sustainable means to reduce anxiety. Limitations and areas for future research are described.
Digital Mental Health Interventions for Young People in Rural South Africa: Prospects and Challenges for Implementation
Authors: Mindu Tafadzwa , Mutero Innocent Tinashe , Ngcobo Winnie Baphumelele , Musesengwa Rosemary , Chimbari Moses John
Published: January 2023

Globally, most young people living with mental health conditions lack access to mental health care but have access to a mobile device. The growing access to mobile devices in South Africa has the potential to increase access to mental health care services through digital platforms. However, uptake of digital mental health interventions may be hampered by several factors, such as privacy, confidentiality, informed consent, and affordability. This study identified the prospects and challenges of implementing a mobile phone-based mental health intervention for young people in Ingwavuma area. Data were collected from 93 young people in three villages purposefully selected in Ingwavuma area. Participants included in the study were aged 16–24. Data were collected through a questionnaire. Thematic and descriptive analysis was performed on the qualitative and quantitative data, respectively. Mental health education was low, with only 22% of participants having received prior education on mental health. About 50% of the participants had come across a mental health app, but none of them had used any of these apps; 87% of participants had Internet access; 60% preferred to use social media to contact a health worker; and 92% suggested that use of digital apps would improve mental health literacy among young people. Barriers to access of digital mental health interventions were identified as the high cost of data, restrictive religious beliefs, limited privacy, lack of native languages on most digital platforms, low digital literacy, and complicated user interface. In uMkhanyakude, uptake of digital mental health apps among the young people was low. We recommend that, developers create context-specific digital applications catered for young people from different cultural backgrounds. Socio-economic issues such as affordability also need to be addressed in developing these tools.
An Iterative, Participatory Approach to Developing a Neighborhood-Level Indicator System of Health and Wellbeing
Authors: Röhrbein Hannah , Hilger-Kolb Jennifer , Heinrich Kathrin , Kairies Holger , Hoffmann Kristina
Published: January 2023

Despite increased awareness of the essential role of neighborhood characteristics for residents’ health and wellbeing, the development of neighborhood-level indicator systems has received relatively little attention to date. To address this gap, we describe the participatory development process of a small-area indicator system that includes information on local health needs in a pilot neighborhood in the German city of Mannheim. To identify relevant indicators, we partnered with representatives of the city’s public health department and used an iterative approach that included multiple Plan-Do-Check-Act cycles with ongoing feedback from local key stakeholders. The described process resulted in a web-based indicator system with a total of 86 indicators. Additionally, 123 indicators were perceived as relevant by stakeholders but could not be included due to data unavailability. Overall, stakeholders evaluated the participatory approach as useful. Even though the onset of the COVID-19 pandemic and the lack of some data elements hindered instrument development, close collaboration with public health partners facilitated the process. To identify and target sub-national health inequalities, we encourage local public health stakeholders to develop meaningful and useful neighborhood-level indicator systems, building on our experiences from the applied development process and considering identified barriers and facilitators.
Microarray Profiling of Differentially Expressed Genes in Coronary Artery Bypass Grafts of High-Risk Patients with Postoperative Cognitive Dysfunctions
Authors: Yazit Noor Anisah Abu , Juliana Norsham , Kadiman Suhaini , Hafidz Kamilah Muhammad , Mohd Fahmi Teng Nur Islami , Abdul Hamid Nazefah , Effendy Nadia , Azmani Sahar , Abu Izuddin Fahmy , Aziz Nur Adilah Shuhada Abd , Das Srijit
Published: January 2023

Postoperative cognitive dysfunction (POCD) is cognitive decline after surgery. The authors hypothesized that gene-level changes could be involved in the pathogenesis of POCD. The present study evaluated the incidence of POCD and its associated differentially expressed genes. This was a prospective cohort study conducted on high-risk coronary artery bypass graft patients aged 40 to 75 years. POCD classification was based on a one standard deviation decline in the postoperative scores compared to the preoperative scores. The differentially expressed genes were identified using microarray analysis and validated using quantitative RT-PCR. Forty-six patients were recruited and completed the study. The incidence of POCD was identified using a set of neurocognitive assessments and found to be at 17% in these high-risk CABG patients. Six samples were selected for the gene expression analyses (3 non-POCD and 3 POCD samples). The findings showed five differentially expressed genes in the POCD group compared to the non-POCD group. The upregulated gene was ERFE, whereas the downregulated genes were KIR2DS2, KIR2DS3, KIR3DL2, and LIM2. According to the results, the gene expression profiles of POCD can be used to find potential proteins for POCD diagnostic and predictive biomarkers. Understanding the molecular mechanism of POCD development will further lead to early detection and intervention to reduce the severity of POCD, and hence, reduce the mortality and morbidity rate due to the condition.