bluuebunny/crossref_metadata_2025 huggingface dataset:
Abcesso das glândulas de Skene: relato de caso
Authors:   USF Cova da Piedade, ACES Almada Seixal, ARS LVT, Morgado Maria Beatriz
Published: April 2022

Introdução: Os abcessos das glândulas de Skene são raros e subdiagnosticados. O seu diagnóstico baseia-se na anamnese e no exame objetivo. Descrição do caso: O presente caso clínico relata o seguimento de uma mulher de 26 anos que recorreu ao centro de saúde por surgimento de uma massa perineal de novo, sensação de esforço para iniciar a micção e repleção vesical. À observação apresentava uma massa procidente periuretral com 2cm de diâmetro, localizada na parede vaginal anterior, com envolvimento do meato urinário, aflorando aos grandes lábios. Foi colocada a hipótese de prolapso uro‑vaginal e pedido estudo ecográfico. Aproximadamente um mês mais tarde, a utente regressa à consulta por dor perineal intensa desencadeada pela introdução da sonda ecográfica endovaginal. Ao exame físico apresentava a mesma massa periuretral – agora com sinais inflamatórios locais francos e saída de exsudado purulento abundante pela uretra. O exame ecográfico efetuado não descrevia quaisquer alterações relevantes. Assumiu-se, como hipótese mais provável, a formação de um abcesso das glândulas de Skene. A utente foi então medicada com azitromicina e cefuroxima, com resolução do quadro. Comentário: Os abcessos das glândulas de Skene apresentam-se como massas periuretrais, associadas a exsudado purulento, dor uretral e/ou alterações urinárias. A evolução temporal do quadro clínico pode ser crucial para o estabelecimento do diagnóstico. Uma vez estabelecido o diagnóstico preconiza-se a antibioticoterapia empírica, tendo em conta os agentes mais frequentemente implicados (Escherichia coli, Neisseria gonorrhoeae e agentes da flora vaginal). Deste modo, perante uma massa periuretral dolorosa em utentes do sexo feminino, a lista de diagnósticos diferenciais deverá incluir a hipótese de abcesso das glândulas de Skene, de forma a não perder a oportunidade de tratamento precoce.
PEMETAAN POTENSI DUSUN WISATA TULAUN
Authors: Rumbayan Meita , Tulenan Virginia , Senduk Xaverius , Thayeb Putra Sholihin
Published: April 2022

Pemetaan kawasan dalam bentuk potret dan informasi potensi dengan memanfaatkan teknologi digital dapat mempermudah proses mendapatkan informasi dan melakukan kajian untuk kawasan Desa Wisata. Artikel mengkaji mengenai pemetaan berbasis foto dengan menggunakan drone pada lingkup kawasan dengan objek studi dusun Tulaun, Desa Lalumpe, Kecamatan Kombi, Kabupaten Minahasa, Propinsi Sulawesi Utara. Dusun wisata ini merupakan bagian dari wilayah pesisir desa Lalumpe yang memiliki potensi dan dapat dikembangkan sebagai kawasan wisata berbasis masyarakat. Dusun Tulaun terletak kurang lebih 60 km dari kota Manado, ibukota Propinsi Sulawesi Utara. Strategi riset/pendekatan dilakukan dalam beberapa tahapan antara lain: (1)Tahap studi literature dengan topik pemetaan desa wisata (2) Tahap diskusi kelompok terpusat dengan pemerintah desa, tokoh masyarakat dan kelompok mitra (3) melakukan pemotretan kawasan dengan alat berupa drone untuk hasil pemetaan (4) melakukan identifikasi dan pemetaan potensi destinasi wisata (5)mengembangkan website profil wisata desa sebagai sarana promosi dan publikasi digital untuk introduksi potensi dusun wisata Tulaun. Hasil riset desa berupa pemetaan potensi sumber daya alam dan wisata dusun Tulaun di desa Lalumpe bisa menjadi starting point pengembangan menuju desa wisata digital dengan nilai tambah desa mandiri energi yang bisa menjadi pilot proyek percontohan untuk mendukung kebijakan green economy dan pariwisata.
Contribution of Job Satisfaction to Organizational Citizenship Behavior: A Survey of the School Teachers of Nepal
Authors: Shrestha Milan
Published: April 2022

Job Satisfaction (JS) and Organizational Citizenship Behavior (OCB) are both considered crucial in an organizational setting. The association between JS and OCB promotes school effectiveness on multiple levels. With this consideration, this research aimed to examine the relationship between them, following a post-positivist philosophy with a cross-sectional survey design. The data collected randomly from 345 respondents were analyzed using correlation and regression analysis and finally interpreted with the social capital and social exchange theory. The results confirmed the positive relationship between job satisfaction and organizational citizenship behavior, which further supports teachers’ high job performances and work productivity. Likewise, the relationship between job satisfaction and organizational citizenship behavior supports organizational commitment and effectiveness among teachers to promote better educational achievement in schools.
Big data y competencia: características y principales teorías del daño desde la perspectiva de los acuerdos entre empresas
Authors: Velasco Sanzo Pablo
Published: April 2022

Los mercados digitales cada vez acaparan una mayor atención por parte de reguladores, autoridades de competencia y gobiernos, como muestra la actividad reciente de dichas autoridades y las iniciativas legislativas para regular a los gigantes tecnológicos a ambos lados del atlántico (tanto en EE UU como en la UE). En este contexto, uno de los aspectos en los que se está poniendo más el foco es en el uso del big data, que se puede considerar ya como un nuevo input junto con el trabajo y el capital, y en los problemas de competencia que pueden derivarse de su acumulación y utilización.
THE IMPACT OF SOCIAL NETWORKS ON STAFF PERFORMANCE
Authors:   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», Zinchenko Galyna , Voloshchuk Vitalii ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», Lobodzynska Tetiana ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute»
Published: April 2022

opinion is listened to and trusted - all this can be achieved by choosing the right promotion strategy on social networks. Analytical data from social networking platforms allow companies and businesses to determine a person's inclinations, beliefs and preferences. Correct use of the social network within the organization can increase the level of personnel involvement in the business process. And employee involvement in this process is akin to customer loyalty. As a result, he not only spends more time on tasks, but also does his job better, as he cares for the result. The purpose of the study is to diagnose the impact of social networks on the effectiveness and efficiency of staff. The article describes the impact of social networks on people's lives, as well as offers information on popular networks and highlights problematic issues, offers solutions for communication in companies through social networks without contradicting the rules of work and data protection. The article will be useful for company managers and their managers for the proper organization of the work process in the team, taking into account the development of social networks. In today's world, social networks are a combination of many possibilities, such as communicating with friends, reading publications, watching movies, the ability to share information, participate in discussions, create a community and much more, which fully allows you to call them a great technological achievement. But there is also the other side of the coin. With the great possibilities comes the trouble. You can't argue that social networks are one continuous trouble, any more than you can say the same about computer games, for example. With a disciplined and correct approach, you can get some benefits and make your life easier. But there is always a risk that addiction to social networks will have a detrimental effect on your psyche.
STATE FINANCIAL CONTROL IN UKRAINE: FOREIGN EXPERIENCE
Authors:   University of State Fiscal Service of Ukraine, Yahodenko Iryna , Hordei Oksana ,   University of State Fiscal Service of Ukraine
Published: April 2022

The article is devoted to the study of the state of public financial control in Ukraine based on the experience of developed countries to increase its efficiency. The state and problems of the state financial control of Ukraine for today were analyzed, its features and content were determined. The activity of the state financial control bodies in January-June 2021 and the dynamics of the volume of violations that led to the loss of financial resources, which were identified by the State Audit Office during January-June 2019-2021, are studied. The main financial violations that led to the loss of resources are described. After analyzing the experience of developed countries in the field of public financial control, namely the United States, Germany, Japan, Great Britain, the bodies of financial control of these countries, the peculiarities of their functioning and the principles by which they operate. To date, control activities in Ukraine are assessed by experts, including international ones, as ineffective. First of all, this is due to the significant level of offenses committed in the field of public finances, ineffective warnings, the prompt detection of which is possible due to the coordination of actions of bodies endowed with control powers. Of course, these indicators are influenced by the actual state of war in which Ukraine finds itself, but no less important factor is the political component, capacity and efficiency of governance. Today, the system of public financial control is the engine of qualitative change in the economy as a whole contributes to the security of public financial resources, non-current and other assets, the correctness of determining the needs of budget funds and liabilities, efficient use of funds and property. At the same time, in the current conditions of Ukraine's economic development, the tasks of the financial control system should be determined taking into account the needs of the country's socio-economic development. Accordingly, in modern conditions, the task of financial control becomes the identification of internal reserves of the state, which can participate in resolving crisis issues in the economy and social sphere. State statistics show that regulatory authorities are working to address this issue. The whole situation indicates the need for coordination of financial control, which involves coordination of functions of all controlling entities and concentration of their efforts on priority areas of control, implementation of best domestic and foreign experience, rapid exchange of information between them. The current course of the state in the system of public administration is associated with the need to increase the role of public financial control. However, there are a number of obstacles. One of them is the lack of appropriate legal and methodological framework for public financial control.
Recomendaciones, consejos y guía para principiantes en investigación, sobre cómo realizar un análisis de la industria y la competencia según Michael E. Porter
Authors:   Universidad de Guadalajara, Arroyo González Luis Alberto , Sánchez Gutierrez José ,   Universidad de Guadalajara
Published: April 2022

This article deals with appendix B from the book Competitive strategy. Techniques for the analysis of the industrial and competition sectors. The appendix is entitled: “How to perform an analysis of the industry”. In it, Porter proposes a methodological strategy to analyze the industry, and provides a series of recommendations on how to carry out field research; proposes categories of raw data in the industry analysis, recommends sources and search studies for the examination detailed, the data collec-tion and the characteristics of the sources that should be consulted. At the same time the article is enriched by various sources that strengthen the concepts raised by the author of the book. The objective of this work is to provide students of administrative areas, academic researchers and beginning professionals of the area, with a valuable tool for research and analysis of industry and competition.
Una mirada de la economía circular a los programas de reducción de residuos en León, Guanajuato. ¿Soluciones concretas o paliativos ambientales?
Authors:   Universidad de Guanajuato, Tagle Zamora Daniel
Published: April 2022

The issue of urban solid waste management (grsu) in León, Guanajuato, has various pending issues, essentially defining a strategy aimed at gradually reducing the generation of waste in the municipality for the decade that begins in accordance with the physical limits and environment of the landfill. The communication and environmental education components, from the public agency as pillars aimed at promoting less waste generation and adequate separation at source, present serious problems of articulation and operation to generate synergies with producers, merchants and consumers. In the institutional, financial, as well as infrastructure part, the para-municipal presents points considered as weak to carry out immediate processes of reduction, separation, treatment and use of the city's waste. In this research, the various programs directed by the municipal public administration in terms of urban solid waste reduction are analyzed from the perspective of the circular economy. Within the methodological approach, semi-structured interviews were carried out with the actors responsible for the various reduction programs of the municipality, as well as the review of various statistical indicators on waste. Within the approach considered for the analysis, the circular economy was selected, especially due to the broad link it has with the field of generation and final disposal of waste. The results found in the investigation indicate that the paramunicipal is initiating a process of collecting and separating waste that they are paying to reduce the income to the landfill; however, the foregoing is not associated with generating new practices of commercial producers and society in general focused on eliminating the generation of waste from origin. The reduction programs therefore represent a mere environmental palliative that pays limitedly to the 2030 sustainable development agenda.
Antecedentes del marco legal normativo y las percepciones económicas de la cannabis en estudiantes de la Universidad de Guadalajara, campus CUCEA
Authors:   Universidad de Guadalajara, Velázquez Crotte Salvador Arturo
Published: April 2022

In our country the lack of information has generated that most of the population per-ceive the cannabis as something negative. In the last few years, several countries around the world are beginning to adopt the decriminalization of this plant for several purposes; Mexico is not the exception, because in the last few years a debate has generated mixed opinions about the subject. The present article has the purpose to identify at first hand the perception of the students from the Centro Universitario de Ciencias Económico Admi-nistrativas (cucea) of the Universidad de Guadalajara (UdeG), of what cannabis is. It was decided that the recollection of information will be only focused on a small sample of the entire population, and focused on the fourteen pregrade programs, this because the young students are more susceptible to have contact with the plant. With the task of ma-king even more breakthroughs of the diverse uses and virtues of this plant, it is imperative to previously known how do the students perceive it, so the best decisions are made accu-rately and with this the best education and communication strategy can be generated, so this way the uses and benefits such as the industrial, medic, and ludic can be shared, and with this settle the basic backgrounds for the society to understand their basic implications. Now with the previously mentioned, a brief review of the cannabis history is shared in how it propagates around the world and our country throughout the time, the arrival to our country and its way to legalization
Redes y activismo político norcoreano. El rol de las organizaciones sociales de ayuda humanitaria, asistencia a desertores y derechos humanos políticos en el proceso de unificación
Authors:   Universidad del Salvador (USAL), del Pilar Álvarez María , Méndez Celina ,   Universidad del Salvador (USAL)
Published: April 2022

En este artículo se analizan los repertorios de acción, vínculos, identidades colectivas y estrategias de presión de las organizaciones sociales de ayuda humanitaria, asistencia a desertores y derechos humanos políticos en Corea del Sur. La propuesta central que guía este trabajo sostiene que las redes de activismo político “norcoreano” tienen un alto nivel de incidencia en las relaciones intercoreanas y en los cambios normativos en torno a la unificación. Se observa que los derechos humanos como identidad colectiva de estas redes favorecen la cooperación entre las Coreas cuando el proceso identitario está enraizado en las dinámicas locales y políticas intercoreanas oficiales, mientras que tienden a desafiar la agenda nacional cuando los actores sociales tienen una mayor circulación en redes de derechos humanos internacionales. Esta investigación fundamenta su propuesta en un estudio cualitativo de casos integrados basado en material institucional, análisis de redes sociales y entrevistas a miembros de las ONG en Corea del Sur.
Eficiencia de las aduanas de la región APEC y los países más dinámicos comercialmente
Authors:   Universidad de Colima, Reyes Real Oscar Bernardo , Zamora Torres América I. ,   Universidad Michoacana de San Nicolás de Hidalgo
Published: April 2022

La originalidad y relevancia de esta investigación radican en la importancia de la función aduanera vista desde un enfoque cuantitativo no paramétrico de dos etapas. De tal manera que el objetivo del presente trabajo es determinar la eficiencia de las aduanas respecto a su desempeño en el comercio internacional, considerando 29 países de las regiones de APEC. Como herramienta metodológica se utiliza el “análisis envolvente de datos (DEA) network”. Los principales resultados muestran que las aduanas más eficientes acorde con las variables consideradas son: China, Alemania, Singapur y Francia, entre otras. Dentro de las limitaciones del trabajo destaca el no incorporar algunos países de la región APEC debido a la falta de información para dichos países, por lo que no se incluyeron. Los hallazgos pueden ser útiles en la gestión pública aduanera a fin de incrementar su eficiencia y así mejorar el flujo comercial de los países analizados.
La Misión Hasekura: la diplomacia internacional que soñó Masamune Date
Authors:   Universidad de Guadalajara, Nakasone Takako
Published: April 2022

Sasaki, Toru. (2021). Keicho ken´o shiset-su: Date Masamune ga yume mita kokusai gaiko [La Misión Hasekura: la diplomacia internacional que soñó Masamune Date]. Tokio, Japón: Yoshikawa kobunkan, 255 pp.
Influencia de los sistemas de información en la productividad de una institución privada de educación superior en México
Authors: Sotomayor Moreno José Ignacio , Rivas Tovar Luis Arturo
Published: April 2022

El trabajo de investigación es de carácter descriptivo, y está enfocado en principio a medir la relación de los sistemas de información con la productividad alcanzada en un estudio de caso de la Universidad del Valle de México, como una institución representativa por su tamaño, dimensiones, amplitud y cobertura. Los resultados indican que la productividad tiende a disminuir cuando el uso y aplicación de los sistemas de información para el cumplimiento de sus tareas; en la parte normativa cuando los responsables tienden a utilizar los reportes emitidos por los sistemas de información administrativa en su función administrativa, y en la parte estratégica cuando los directivos se apoyan con el uso de los sistemas de información para el proceso de toma de decisiones, facilitando el crecimiento, desarrollo y permanencia de la organización en el sector educativo.
Participación de México en el comercio internacional
Authors: Vázquez Sandoval Manuel , González Uribe E. Georgina , Urzúa López José de Jesús , Flores Mora Juan Antonio
Published: April 2022

México es una de las trece economías más importantes en el comercio internacional. Exporta productos a los cinco continentes, aunque con la gran concentración en el continente americano y particularmente en Estados Unidos de Norteamérica, mercado al que en el año de 200 se destinó 89% de las ventas nacionales. La ubicación geográfica, colindante con la economía más poderosa del país consumidor número uno en el mundo, ha limitado las posibilidades y necesidades de diversificación. A Europa, segundo continente en importancia para los productos mexicanos, solo se le vende 3.90% de las exportaciones. En cuanto a productos, se ha disminuido la dependencia del petróleo y otros productos primarios y han crecido las exportaciones de manufactureras, como automóviles, equipos electrónicos y productos químicos. Por otro lado, la apertura comercial de México, manifestada con la pertenencia a organismos internacionales como la OMC, OCDE y APEC, así como la firma de múltiples tratados comerciales, no ha servido para equilibrar el comercio.
Conflict: influence on the satisfaction of the distribution channel members
Authors: Raúl González Ernesto , Sandoval Jésica
Published: April 2022

El propósito principal de este artículo es analizar el efecto de los conflictos entre los miembros del canal de distribución (que se centra en el turismo) en el nivel de satisfacción experimentado por las empresas de estudio al comercializar servicios del turismo. En la primera parte de este estudio, consideramos de una manera teórica, algo de los aspectos en el contenido de los conflictos que están presentes en los canales de distribución así como la satisfacción experimentada. Concluimos a través de los resultados de un estudio empírico el cual confirma que las situaciones de conflicto afectan de una manera negativa los niveles de satisfacción que los miembros experimentan en el canal de distribución mientras participan en el intercambio (en este caso de servicios turísticos)
Estrategias de comercio electrónico para implantar un modelo de marketing por internet
Authors: Sánchez E. José , González Georgina
Published: April 2022

Con el comercio electrónico (CE) se ha revolucionado la forma de hacer negocios, lo que permite a las empresas y consumidores nuevas posibilidades de ofrecer y adquirir productos, con muchas ventajas, tales como: la reducción de costos, atención directa al cliente y eliminación de barreras geográficas y de tiempo.Este nuevo concepto de mercadotecnia utiliza elemento del marketing tradicional, pero marca una gran diferencia frente éste, por las características de espacio, el tiempo, la creación de imagen, la dirección de la comunicación, la interactividad y el llamado de atención.
ВИКОРИСТАННЯ TELEGRAM-КАНАЛУ У ФОРМУВАННІ ГОТОВНОСТІ МАЙБУТНІХ УЧИТЕЛІВ УКРАЇНСЬКОЇ МОВИ ТА ЛІТЕРАТУРИ ДО ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ
Authors: Петрович Ольга Борисівна , Петрович Сергій Драганович , Пойда Оксана Андріївна
Published: April 2022

У статті розглядаються особливості створення й практичного застосування Telegram-каналу для організації як індивідуальної, так і групової роботи студентів-філологів з навчальної дисципліни «Методика навчання літератури» у форматі дистанційної освіти. Обґрунтовано актуальність впровадження мобільного додатка Telegram для формування готовності майбутніх учителів-словесників до професійної діяльності. Аналіз наукових джерел дав змогу стверджувати, що процес фахової підготовки потребує осучаснення методів навчання, а використання інформаційно-комунікаційних технологій в освіті, зокрема кросплатформового месенджера Telegram, дозволяє персоналізувати пізнавальну діяльність, полегшити поширення навчального контенту серед студентів академічної групи поза просторово-часовими обмеженнями, уможливлює отримання зворотного зв’язку в умовах асинхронного режиму навчання у форматі дистанційної освіти. Узагальнено вітчизняний та зарубіжний досвід інтеграції Telegram-каналів у нинішні освітні практики. Описано покроковий алгоритм створення Telegram-каналу «MNUL» та його програмування для подальшої публікації навчального контенту з «Методики навчання літератури». Деталізовано змістове наповнення каналу для опанування навчальної дисципліни «Методика навчання літератури». Уточнено, що освітній процес ґрунтується на оприлюдненні завдань з дисципліни у форматі дописів у Telegram-каналі «MNUL» з прикріпленням інтерактивних навчальних матеріалів з інструкціями, посиланнями, відеоконтентом, ілюстраціями тощо. Акцентовано, що органічне поєднання традиційних, інформаційно-комунікаційних та інтерактивних освітніх технологій активізує майбутніх учителів-словесників до дослідницько-пошукової й творчої роботи, сприяє створенню сприятливої атмосфери для прояву студентом-філологом власної ініціативи до навчання, стимулює до самовираження, мотивує їх до саморозвитку, привчає до самостійного здобуття знань та їх практичного застосування, а також до вправного користування Інтернетом, сучасними гаджетами й мобільними додатками тощо. Визначено перспективи дослідження проблеми застосування Telegram-бота для створення тестування з навчальної дисципліни «Методика навчання літератури» з метою перевірки освітніх досягнень майбутніх учителів української мови і літератури.
ОСНОВНІ НАПРЯМИ ІМПЛІМЕНТАЦІЇ ІНФОРМАЦІЙНО-КОМУНІКАЦІЙНИХ ТЕХНОЛОГІЙ У ПРОЦЕС НАВЧАННЯ НІМЕЦЬКОЇ МОВИ СТУДЕНТІВ-ФІЛОЛОГІВ
Authors: Галицька Олена Богуславівна , Лозицька Марія Петрівна
Published: April 2022

У статті здійснено дослідження імплементації інформаційно-комунікаційних технологій (ІКТ) у процес навчання німецької мови (для спеціальності 035 «Філологія» за освітньою програмою «Мова і література (німецька). Переклад») у Волинському національному університеті імені Лесі Українки. Запропоновано основні напрями імплементації ІКТ у процес навчання німецької мови. .Встановлено, що до найбільш ефективних і результативних інформаційно-комунікаційних технологій у формуванні професійних компетенцій майбутніх фахівців належить використанню в освітньому процесі: електронних курсів навчальних дисциплін на платформі Moodle; електронних матеріалів у репозитарії ВНУ імені Лесі Українки; хмарних технологій; мобільних освітніх застосунків, зокрема застосування BYOD-підходу в освітньому процесі за різними сценаріями; прикладних ІКТ та «розумних» об’єктів; подкастів, соціальних медіа і месенджерів. Ґрунтовний аналіз цифрових освітніх ресурсів, особливостей їх дидактичного потенціалу засвідчує необхідність їх застосування в освітньому процесі вищої освіти, а саме в змішаному та дистанційному навчанні. Виокремлено труднощі мобільного навчання, які виникали під час практичних занять і організації самостійної роботи. У статті простежено роль викладача, який з транслятора змісту навчання перетворюється на організатора комунікацій та експерта, функції якого полягають у грамотній стратегічній постановці завдань, організації процесу їх вирішення й експертизі отриманих студентами рішень.На основі застосування інструментів ІКТ на лекційних і практичних заняттях з вивчення німецької мови запропоновано функційну класифікацію Веб2.0-інструментарію: тренувальну, комунікаційно-кооперативну, пошуково-інформаційну, презентаційну, гейміфікаційну та експериментальну функції. Встановлено, що використання Веб2.0-інструментів в освітньому процесі підвищує якість оволодіння трансферабельними вміннями завдяки стимулам активізації пізнавальної діяльності під час одночасного розширення рецептивних можливостей студентів.
Social Impact and Quality of Life of Patients with β-Thalassaemia: A Systematic Review
Authors: Greco Francesca , Marino Franca
Published: April 2022

β-Thalassaemia (BT) is a hereditary genetic blood disease caused by a mutation in the gene that encodes the haemoglobin protein. In the most severe forms, BT forces patients to undergo frequent blood transfusions, which has a significant impact on the quality of life. Classified as rare, BT is very common in the Mediterranean area, and is also found in the Middle East, Central Asia, India, South America, and North Africa.

This disease does not currently have a definitive cure, although technological progress and new gene therapies are achieving promising results.

This literature review was conducted with the aim to understand how BT affects patients' lives in various social contexts in which they are involved. The authors also aimed to understand which methods are used for this assessment and the possible social actions that can help in the management of the disease.

Electronic databases, including PubMed, Scopus, and Web of Science, were used to search for the articles. Related article titles were selected and reduced to the abstracts of the relevant articles, after which the selected full articles were reviewed.

The reviewed articles showed consistent agreement in observing that the quality of life of patients with BT is considerably lower compared with the healthy population in terms of physical, emotional, social, and functioning at school. The negative results highlight the significance of the introduction of suitable programmes by healthcare providers, counsellors, and education authorities to provide psychosocial support, and improve academic performance. In addition, genetic counselling and intervention programmes would positively impact the lives of patients with thalassaemia.
Startling or Seductive? An Analysis of Play for Today’s Title Sequences
Authors: May Tom
Published: April 2022

Play for Today has been widely regarded as a prestigious vehicle for one-off dramas on topical issues. Based on accounts by producers, composers and graphic designers, this article will provide a historical analysis of the changing image of Play for Today through the close analysis of its seven title sequences. Focusing on how the different sequences invested the strand with a particular identity and prepared audiences for the plays that followed, it identifies two main modes of address. It argues that the Play for Today image was at its most startling during the periods 1971–3 and 1977–82 when the title sequences signalled to viewers that Play for Today would present important – often politicised – drama with a proximity to the news. Other sequences – during 1973–7 – sought instead to ‘seduce’ viewers by foregrounding the strand’s humanism and eclecticism.
Assessment of the need for the use of digital medical decision support system in the diagnosis of diseases of the oral mucosa
Authors: Margaryan E. G. , Kadzhoian A. G. , Novozhilova N. E. , Atanesyan A. V. , Komogortseva V. E. , Bledzhyants G. A.
Published: April 2022

Aim. To substantiate the need for the use of digital systems to support medical decision-making in the diagnosis of diseases of the oral mucosa.

Materials and Methods. The study was conducted by the method of anonymous questionnaires, dedicated to the evaluation of the use of digital systems to support medical decision-making in the diagnosis of diseases of the oral mucosa, on the basis of the Institute of Dentistry I.M. Sechenov First Moscow State Medical University (Sechenov University). The study analyzed 200 questionnaires of doctors aged 20 to 70 years. The main methods used in the study: statistical method using the Kruskal-Wallis test, followed by pairwise comparison using the Mann-Whitney-Wilcoxon test (with Benjamin-Hochberg correction for multiple comparisons), questionnaire.

Results. It was revealed that dentists with a long experience of medical practice from 15 to 20 years (77,8%) more often detect manifestations of diseases of the oral mucosa at a medical appointment. When analyzing the diagnosis of oral mucosa diseases, depending on the specialization of the dentist, it was found that this group of pathologies is more often determined by orthodontists(68,8%). At the same time, for the majority of specialists (59%), the diagnosis of diseases of the oral mucosa is difficult. Dentists of various specializations in most cases noted difficulties in determining a presumptive diagnosis (59.5%). At the same time, most specialists associated this with a lack of knowledge and experience in working with patients with diseases of the oral mucosa (66.5%) and with a large variety forms of diseases of the oral mucosa (54%) and resorted to the use of additional sources of information from textbooks, manuals, information articles, as well as the help of colleagues (64.5%). However, at clinical appointments, many doctors faced a lack of time to use reference literature (48.5%). As a result of the survey, it was also revealed that the majority of respondents (64,5%) would like to use the medical decision support system integrated into the medical information system of a medical institution.
Research of the effect of the collagen cone on the regeneration of the postextraction socket
Authors: Stomatov D. V. , Dolgalev Al. Al. , Stomatov A. V. , Nikishin D. V. , Dzheyranova L. R. , Gabrielian N. G.
Published: April 2022

The development of dental implantology has actualized the improvement of approaches to tooth extraction surgery, one of the main goals of which is to maximize the preservation of the volume of surrounding tissues, prevention of infectious and inflammatory complications. This article presents a study of osteoplastic material based on animal collagen, which is widely used in the daily practice of a dental surgeon to fill in bone defects, including in the technique of augmentation of the socket of removed teeth. The results of the study were evaluated clinically, radiologically and histomorphologically.
Art therapy as a method of correction of negative emotions at dental appointment
Authors: Nikolskaya I. A. , Kopetskiy I. S.
Published: April 2022

In this article, a study is made on the correction of the emotional sphere of children of primary school age. The presented modern correctional program of art therapy-neuro graphics, the objectives of which are the removal of internal constraints, the harmonization of the emotional state, the transformation of reality and modeling of the future, based on the methods of art therapy, aimed at reducing the level of anxiety in children. Neurographics doesn’t require artistic or visual art skills, so every child can participate in this work. Neurographics helps to reduce the anxiety of preschool children, helping to emotionally and personally cognize oneself and other people, promotes knowledge of the world around, helps to realize one’s abilities, the ability to become more active, relax, express one’s emotions and feelings, establish new trust levels of communication. The developed program aimed at reducing anxiety through neurographics, with longer corrective work, will lead to the fact that the level of anxiety manifestations in preschool children will decrease to a minimum.
COMPARISON OF L-MOMENT AND METHOD OF MOMENTS AS PARAMETER ESTIMATORS FOR IDENTIFICATION AND CHOICE OF THE MOST APPROPRIATE RAINFALL DISTRIBUTION MODELS FOR DESIGN OF HYDRAULIC STRUCTURES
Authors: Agbonaye Augustine Iyekeoretin , Otuaro Ebierin Akpoebidimiyen , Izinyon Osadolor Christopher
Published: April 2022

In rainfall frequency analysis, the choice of a suitable probability distribution and parameter estimation method is critical in forecasting design rainfall values for varying return periods at every location. Previously, some researchers in Nigeria used the method of moments (MoM) while others used the L-moment method (LMM) as parameter estimators. However, a more accurate result is obtainable if both estimators are used and their results are compared and ranked to obtain the most appropriate distribution models for each location This study compared the performance of two forms of parameter estimation, namely the method of moments (MoM) and the L-moment method (LMM). This was aimed at identifying and selecting the best fit probability distribution models among three distribution models for the design of hydraulic structures. These models are Generalized Pareto (GPA), Generalized Extreme Value (GEV), and Gumbel Extreme Value (EVI). Annual rainfall series of ten gauging stations with data from 33-50 years from ten southern States of Nigeria obtained from NIMET were used for Rainfall Frequency Analysis (RFA). At five locations, the best fit probability model was the GPA probability distribution model with L-Moment. EVI and GEV probability distribution models with the method of moments were the most appropriate probability models at two locations each. EVI probability distribution model with the L-moment was the most appropriate probability model at one place. The findings confirmed that no single distribution outperformed all others at all stations. Since no single model is regarded preferable for all practical purposes, the best-fit probability model with parameter estimator at any location is site-specific. Consequently, available models and parameter estimators are filtered based on the situation at hand and the type of data available. The identified best fit models with the most appropriate parameter estimator would be a tool to help decision-makers in sizing hydraulic structures in the area.
REMEDIATION OF CONTAMINATED SOIL WITH CRUDE OIL BY COMPOSTING
Authors: Yap Chi Nam , Hadibarata Tony
Published: April 2022

In recent years, one of the primary issues noted worldwide in the environment is the contamination of crude oil in soil. In comparison to traditional methods, bioremediation offers a potential alternative for removing hydrocarbon pollution from the environment. This review paper gives an overview of the benefits, mechanism, and operation of aerobic composting remediation of soil contaminated with crude oil. Within this study, it was demonstrated that with composting technology, one could successfully treat crude oil contaminated soil with a > 90% removal efficiency. Aerobic composting utilizes aerobic bacteria and fungi that require oxygen to grow and biodegrade crude oil’s biological component into carbon dioxide and water, whereas anaerobic composting utilizes anaerobic microbes that grow in the absence of oxygen and convert the crude oil’s organic component primarily into methane. In terms of efficiency, biodegradation capacity, and rate, aerobic conditions outperform anaerobic conditions. Numerous parameters have been discussed and demonstrated to have an effect on the composting condition and also on the bacteria and fungi used to biodegrade crude oil contaminants at various stages of the composting process, including initial concentration, soil type, soil/compost ratio, aeration rate, moisture content, C/N ratio, pH, and temperature. Microbes use crude oil organic matter as carbon and energy sources during the composting process, whereas fungi produce enzymes that catalyze crude oil oxidation reactions. It is believed that the mutualistic and competitive interactions between bacteria and fungi maintain a robust biodegradation system. The thermophilic phase exhibited the highest rate of biodegradation. However, the presence of a diverse and dynamic microbial community throughout the composting process ensures that crude oil degradation occurs. The efficient composting processes using specific microbes need to be investigated.
Data Visualization in Data Science
Authors: Sakib S M Nazmuz
Published: April 2022

Many of the important theoretical and practical issues that need to be addressed when developing data visualizations have been covered in the chapters that precede them. I also reviewed and evaluated a variety of data visualization examples, along with common mistakes and helpful approaches. Based on what we've learned, developing an efficient and ethical way to visualize data can be challenging. This chapter covers a wide range of topics, including the future of data visualization and new data visualization technologies. Finally, I have come to the conclusion of our study on data visualization. In the eleven chapters preceding this one, I have reviewed some of the most important theoretical and practical components of visualization methods and applications, and their applications. As I have seen, developing an efficient and effective approach to building a data visualization application is challenging. This procedure represents the relevant data.
Data Visualization in Data Science
Authors: Sakib S M Nazmuz
Published: April 2022

A lot of the important theoretical and practical issues that need to be addressed when developing data visualizations have been covered in the chapters that precede them. I also reviewed and evaluated a variety of data visualization examples, along with common mistakes and helpful approaches. Based on what we've learned, developing an efficient and ethical way to visualize data can be challenging. This chapter covers a wide range of topics, including the future of data visualization and new data visualization technologies. Finally, I have come to the conclusion of our study on data visualization. In the eleven chapters preceding this one, I have reviewed some of the most important theoretical and practical components of visualization methods and applications, and their applications. As I have seen, developing an efficient and effective approach to building a data visualization application is challenging. This procedure represents the relevant data.
A Commentary on Song of Moses in the Exodus 15:1-7 (LXX-Rahlfs)
Authors: Chia Philip Suciadi , Juanda Juanda
Published: April 2022

Studying the books in the Old Testament which were originally in Hebrew, then studied through the Greek edition with the Septuagint will broaden horizons in Biblical studies. There are various editions of the Septuagint. In this study, it will use Rahlfs' edition. This edition is the most widely spread edition of the Septuagint. Alfred Rahlfs edition of the Septuagint (Rahlfs Septuagint), is a critical edition of the Septuagint published for the first time in 1935 by the German philologist. Through this paper, a structured study of the text of Exodus 15:1-7 will be presented.
Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway
Authors: Lv Bin , Shen Naiting , Cheng Zhangrong , Chen Yuhang , Ding Hua , Yuan Jishan , Zhao Kangchen , Zhang Yukun
Published: April 2022

The repair and motor functional recovery after spinal cord injury (SCI) has remained a clinical challenge. Injury-induced gliosis and inflammation lead to a physical barrier and an extremely inhibitory microenvironment, which in turn hinders the recovery of SCI. TLR4-NF-κB is a classic implant-related innate immunomodulation signaling pathway and part of numerous biomaterial-based treatment strategies for SCI. Numerous experimental studies have demonstrated that the regulation of TLR4-NF-κB signaling pathway plays an important role in the alleviation of inflammatory responses, the modulation of autophagy, apoptosis and ferroptosis, and the enhancement of anti-oxidative effect post-SCI. An increasing number of novel biomaterials have been fabricated as scaffolds and carriers, loaded with phytochemicals and drugs, to inhibit the progression of SCI through regulation of TLR4-NF-κB. This review summarizes the empirical strategies for the recovery after SCI through individual or composite biomaterials that mediate the TLR4-NF-κB signaling pathway.
Toxicity Profiling of Bacterial Inclusion Bodies in Human Caco-2 Cells
Authors: Barguilla Irene , Unzueta Ugutz , Carratalá Jose Vicente , Cano-Garrido Olivia , Villaverde Antonio , Hernández Alba , Ferrer-Miralles Neus
Published: April 2022

Bacterial inclusion bodies (IBs) are discrete macromolecular complexes that appear in recombinant prokaryotic cells under stress conditions. These structures are often discarded for biotechnological uses given the difficulty in recovering proteins of interest from them in a soluble form. However, recent approaches have revealed the potential of these protein clusters as biomaterials to promote cell growth and as protein depots for the release of recombinant proteins for biotechnological and biomedical applications. Although these kinds of natural supramolecular complexes have attracted great interest, no comprehensive study of their toxicity in cell cultures has been carried out. In this study, caco-2 cells were exposed to natural IBs, soluble protein-only nanoparticles (NPs), and non-assembled versions of the same protein for comparative purposes. Cytotoxicity, oxidative stress, and genotoxicity were analyzed for all these protein formats. Natural IBs and soluble protein formats demonstrated their safety in eukaryotic cells. No cytotoxicity, genotoxicity, or oxidative stress was detected in caco-2 cells exposed to the protein samples in any of the experimental conditions evaluated, which covered protein concentrations used in previous biological activity assays. These conditions evaluated the activity of protein samples obtained from three prokaryotic hosts [Escherichia coli and the endotoxin-free expression systems Lactococcus lactis and ClearColi® BL21 (DE3)]. Our results demonstrate that natural IBs and soluble protein nanoparticles are non-toxic materials for eukaryotic cells and that this may represent an interesting alternative to the classical unassembled format of recombinant proteins for certain applications in biotechnology and biomedicine.
Heterometallic Metal-Organic Framework Based on [Cu4I4] and [Hf6O8] Clusters for Adsorption of Iodine
Authors: Hu Huancheng , Chen Fangyun , Zhang Zhanyun , Liu Dongcheng , Liang Yuning , Chen Zilu
Published: April 2022

Heterometallic metal-organic framework (MOF) as a kind of porous material is very important because of its excellent properties in catalysis, magnetic, sensor, and adsorption fields, but the reasonable design and syntheses of these are still challenging. Herein, we prepared one heterometallic MOF with the formula [Hf6(μ3-OH)8(OH)8][(Cu4I4) (ina)4]2·22DMF (NS-1, ina = isonicotinate). Single-crystal X-ray diffraction analysis revealed that NS-1 is a three-dimensional network with flu topology, constructed from 8-connected [Hf6(μ3-OH)8(OH)8]8+ and 4-connected [Cu4I4] clusters as second building units (SBUs). To our best knowledge, NS-1 is a rare example with two different metal clusters as SBUs in heterometallic Hf-based MOFs. Interestingly, NS-1 exhibits a reversible adsorption performance for iodine in the cyclohexane solution, the adsorption kinetics fits well with the pseudo-second-order equation, and the Freundlich model relating to multilayer adsorption better describes the process of iodine absorption.