bluuebunny/crossref_metadata_2025 huggingface dataset:
Representation of Educational Values in Clouds Movie
Authors: Elo Beili Nining Krisnantari , Daniela Lerissa
Published: March 2023

This study examined the representation of the educational values in Clouds as presented by the four main characters, which are Zach, Amy, Sammy, and Zach's mother by utilizing the three metafunctions concepts by Kress and Leeuwen (2006) and the theory of education value by Linda and Richard in Elmubarok (2019). This study used a qualitative descriptive method. This research found that there are 10 out of 12 educational values. The researcher did not find purity and respect values. The educational values can be seen along with the four main characters' presentation in a frame by their surroundings or the clothing they are wearing, or what is known as representational metafunction. Next, how the actors interact with one another in a frame or scene through eye contact, spoken words, and actions, or what is known as interactional meta-function. And the last is through the compositional meta-function which describes how characters and objects are positioned, how much space they take up, and how well they are portrayed. Readers can adopt the morals portrayed in the movie as a good guide in daily life and be inspired to treat others well.
The Effect of Peer Assisted Learning Strategies (PALS) Toward Students’ Reading Comprehension
Authors: Khotimah Devi Nurul , Mulyana Agus , Nuraini Hery
Published: March 2023

The study's purpose was to clarify how the peer-assisted learning method (PALS) affected students' reading comprehension in order to increase their engagement in text discussion and increase their motivation to read. The result showe that s Students' knowledge of daily life and the environment was increased. The 253 students in the entire 10th grade courses at SMAN 14 Kota Tangerang made up the study's sample population. Then, using random sampling, 72 students were chosen as the research's sample. Peer Assisted Learning Strategy (PALS) as a variable X and short answer test students' reading comprehension as a variable Y were used to collect the data. Pre- and post-test data were collected. While the control class scored 28.64 with a minimum of 7 and a maximum of 47, the experimental class's PALS score was 38.44, with a minimum of 10 and a maximum of 57. The results of the Mann-Whitney U Test's calculation of the null hypothesis can be seen; the value in the control class was lower than the t-table with a value of 0.0650.05, while the value in the experiment class was higher with a value of 0.109>0.05. Given that Ha was approved and Ho was refused, it can be said that the Peer Assisted Learning Strategy (PALS) has a considerable impact on students' reading comprehension in the 10th grade of SMAN 14 Kota Tangerang.
Pengaruh Brand Sponsor terhadap Brand Awareness di Institusi Pendidikan pada Media Cat Lantai
Authors: Arifrahara Gema
Published: March 2023

AbstrakBrand merupakan identitas mendasar dari suatu produk yang secara kongkrit nilai dari produknya telah dapat dinikmati oleh konsumennya. Sebuah brand dapat menjadi sponsor dan memiliki kekuatan untuk mempersuasif konsumennya agar tetap menjaga posisinya dan tetap berada kuat pada benak konsumennya. Belum ada riset yang melihat bagaimana pengaruh brand sponsor yang disematkan pada ruang publik suatu institusi pendidikan khususnya menggunakan media cat lantai. Upaya itu digunakan oleh perusahaan penerbit Erlangga untuk tetap menguatkan brandnya pada benak siswa-siswa sebuah sekolah. Menggunakan media cat lantai Erlangga menyematkan brand logonya pada bagian tengah dilapangan olah raga. Metode penelitian yang digunakan adalah metode deskriptif-kuantitatif. Riset ini menggunakan pendekatan berdasarkan objek visual yang mana secara deskriptif dapat diuraikan berdasarkan objek kongkrit dan aspek pemirsanya. Dalam riset ini dilakukan interview dan pencarian data melalui questionare kepada 150 responden. Dari temuan yang didapat dalam riset ini maka brand sponsorship dapat mempengaruhi dari awareness pada brand utamanya khususnya pada institusi pendidikan namun tidak dapat mengurangi kekuatan brand institusi. Brand sponsorship dapat menjadi sebuah gangguan namun dapat pula menjadi suatu dukungan terhadap brand institusi. Kata kunci: brand awareness, brand sponsorship, cat lantai  AbstractThe brand is the basic identity of a product which concretely the value of the product can be enjoyed by consumers. A brand can become a sponsor and has the power to persuade its consumers to keep its position and stay strong in the minds of its consumers. There is no research that looks at the influence of brand sponsors embedded in the public spaces of an educational institution, especially using floor paint media. Efforts used by the publishing company Erlangga to continue to strengthen its brand in the minds of students of a school. Using floor paint, Erlangga embeds his brand Logo in the center of the sports field. The research method used is descriptive-quantitative method. This research uses an approach based on visual objects which can be described descriptively based on concrete objects and aspects of the audience. In this study, interviews and data were searched through questionnaires to 150 respondents. From the findings obtained in this study, brand sponsorship can affect brand awareness, especially in educational institutions but cannot reduce the strength of brand institutions. Brand sponsorship can be a distraction but it can also be a support for brand institutions. Keyword: brand awareness, brand sponsorship, floor paint
Preferensi Media Para Millenial terhadap Televisi Konvensional (Free To Air) dan Layanan Video Berlangganan (Over The Top)
Authors: Wijaya Erris , Rahmanto Andre , Muhammad Albert
Published: March 2023

AbstrakPara milenial memiliki ketergantungan terhadap gadget dan internet dalam memilih media hiburan. Televisi konvensional (free to air) yang berjaya selama puluhan tahun, harus bersaing dengan berbagai media untuk merebut hati para milenial. Salah satunya adalah layanan over-the-top atau konten video berlangganan melalui jaringan internet. Amazon Prime Video, Catchplay, Iflix, Mola TV, Netflix, Vidio, VIU, Disney+Hotstar, RCTI+, WeTV, dan Vision+ adalah contoh platform over-the-top yang ada di Indonesia. Penelitian ini bertujuan untuk mengetahui perubahan konsumsi media televisi dengan keberadaan over-the-top di kalangan milenial. Penelitian ini dilakukan dengan metode kualitatif deskriptif. Pengumpulan data dilakukan melalui wawancara dan studi literatur. Analisis data dilakukan dengan melakukan kondensasi data, penyajian data, penarikan kesimpulan dan verifikasi. Hasil penelitian menunjukkan terjadinya pergeseran pola konsumsi media di kalangan milenial. Over-the-top memberikan kepuasan dari sisi fleksibilitas, ketiadaan gangguan commercial break dan ragam tayangan yang dapat dipilih. Namun, over-the-top memunculkan ketidakpuasan karena biaya berlangganan yang dikenakan dan jaringan internet yang tidak memadai. Kata Kunci: analisis audiens, milenial, over-the top, preferensi media, televisi AbstractMillennials depend on gadgets and the internet to choose entertainment media. Conventional television (free-to-air) which has triumphed for decades, must compete with various media to attract the millennials. One of them is over-the-top or subscription video content through the internet. Amazon Prime Video, Catchplay, Iflix, Mola TV, Netflix, Vidio, VIU, Disney+Hotstar, RCTI+, WeTV, and Vision+ are examples of over-the-top platforms in Indonesia. This research aims to find out changes in television media consumption with the existence of over-the-top among millennials. This research was conducted using a qualitative descriptive method. Data collection was conducted through interviews and literature studies. Data analysis was carried out by data condensation, data display, conclusion drawing and verification. The results showed a shift in media consumption patterns among millennials. Over-the-top provides satisfaction in terms of flexibility, the absence of commercial breaks, and the variety of shows. However, over-the-top raises dissatisfaction due to subscription charges and the inadequate of internet connection.   Keywords: audience analysis, millennials, media preferences, over-the top, television
The Effect of Autism Spectrum Disorder on the Processing of Neural Response Metaphors
Authors: SAKIN Bertuğ , KAFTAR Yasemin , ALBAY Gaye
Published: March 2023

Objective: The aim of this research is to describe the processing of neural response metaphors in individuals with autism spectrum disorder (ASD) speaking Turkish as their native language and to form the basis for further research in this field.

Methods: In this study, a single case study method was used. The data was collected by means of a structured questionnaire. The answers were recorded with the “Systematic Analysis of Language Transcripts” (SALT) program, and the data obtained was summarised using descriptive analysis.

Results: It was found out that the participant had difficulty comprehending, interpreting and using mimics and gestures. He struggled matching emotions and situations with expressions denoting them as well as determining how a person experiencing these emotions and situations might look like. The participant turned out to have reduced ability to interpret idioms and proverbs related to emotions, decide on what actions can be performed at the given place, and form a situation-effect relationship. The participant experienced problems interpreting and using new, formulaic, and malformed metaphors as well metaphors with literal meaning, and could hardly identify and correctly interpret conceptual metaphors within idioms and proverbs.

Conclusion: People with ASD experience difficulty with processing of neural response metaphors by the native speakers of Turkish. The disorders identified within the scope of our research result from the deficiencies of the theory of mind in individuals with ASD, which is supported by other studies on individuals with ASD having different mother tongues.
Time-Dependent Change of Color and Translucency of Recent Restorative Materials in Various Beverages
Authors: KARAKAŞ Seda Nur , KÜDEN Cihan
Published: March 2023

Objective: The aim of this study was to evaluate the time-dependent changes in optical properties of recent tooth-colored restorative materials in commonly used coloring beverages.

Method: A total of 200 specimens of four different materials (Alkasite, ACTIVA, Equia Forte, Zirconomer) and a composive material as the control group were prepared in Teflon molds and the materials were immersed in four different solutions (coffee, cola, ice tea and saliva) (n=10). Color measurements were performed with a spectrophotometer at baseline, 7, 14 and 28 days. Color changes, translucency parameters (TP) and contrast ratios of the materials were calculated. The data were analyzed by repeated measurements and three-way ANOVA and post hoc Tukey tests.

Results: Alkasite showed the greatest color change for all solutions in all immersion periods compared to other materials (p
The Prevalence of Drug-Drug Interactions and Reported Therapy Related Side Effects in Oncology Out-Patients
Authors: MUHAMMAD UMAR Rashida , CAN Zeynep Yeşim , GÜVEN Ece , KARATAŞ KOÇBERBER Emine , OLMEZ Omer Fatih
Published: March 2023

Objective: The use of multiple medications in cancer patients is unavoidable; thus, adverse drug-drug interactions are frequent. This study aims to assess the prevalence of potential drug interactions in oncology patients visiting the outpatient chemotherapy unit. Method: Demographic and health-related information of patients visiting an outpatient chemotherapy unit was recorded using a pre-prepared form. A comprehensive list of all concurrently used medications was compiled and checked for interactions with the Micromedex online drug interaction tool. Results: A total of 179 adult patients were included. We recorded an average of 9.3 drugs per patient with 79 patients using more than 10 drugs. A total of 1671 drugs including 303 chemotherapeutic agents were assessed for drug-drug interactions. A total of 374 interactions, of which 203 were significant, were recorded in 118 (65.9%) patients with an average of 3.2 interactions per patient. Only 46 major interactions were recorded for anticancer agents. Cyclophosphamide (n=13) and cisplatin (n=12) were involved in most interactions. The number of interactions correlated with the number of drugs used (p=.001) and the presence of comorbidities (p=.002). The presence of comorbidities increased the risk of interaction by 1.21 (p=.04). Recorded side effects were not correlated to drug interactions. Conclusion: Medication review in cancer patients is essential in establishing all medications used by patients. Routine assessment in terms of potential drug interactions and evaluation of these interactions by a qualified pharmacist may help in optimizing patient outcomes.
The Assessment of Neurological Development of the Infants with Prenatal COVID-19 Exposure
Authors: AYÇA Senem , YÜKSEL Semra , YAŞAT NACAR Hatice , ARICAN Pınar
Published: March 2023

Objective: The effects of prenatal coronavirus 2019 disease (COVID-19) exposure on the infantile neurological development are unknown. It has been considered that the inflammatory, thrombotic, and vascular changes occurred in the placentas taken from pregnant women diagnosed with COVID-19 and the inflammatory nature of COVID-19 infection may lead to negative obstetric and neurological events. We aimed to assess the potential neurological effects of prenatal COVID-19 exposure on the infant.

Methods: The present study included 2–12-month-old infants born to women with positive real-time reverse transcription polymerase chain reaction test results for COVID-19 from the population of pregnant patients under routine follow-up. The neurological examinations and the Denver II Developmental Screening Test (DDST II) were performed for 41 infants aged 2–12 months to assess the neurological effects of prenatal COVID-19 exposure.

Results: The average gestational age of the infants was 38.7 ± 1.9 weeks, and the average birth weight was 3198 ± 543 g. Eight of the infants had a history of hospitalization in the neonatal intensive care unit. The neurological examination and the neuromotor development of 40 (96%) infants were normal for their age group. Only one infant had abnormal neurological examination and DDST II result.

Conclusion: The findings of the study suggest that prenatal COVID-19 exposure has no negative neurological impact on infants. Long-term prospective studies with larger sample sizes are needed for more comprehensive assessment of the neurological effects of prenatal COVID-19 exposure on the infants.
Complementary and Alternative Medicine Uses of Individuals Diagnosed With Chronic Diseases
Authors: OKTAR Didem , METİNTAS Selma , ÖNSÜZ Muhammed Fatih , ÖCAL Ece Elif , ÇALIŞKAN PALA Seval
Published: March 2023

Objective: The aim of the study was to evaluate the use of CAM practices by individuals who have been admitted to health institutions and have been diagnosed with chronic diseases.

Methods: Patients with a diagnosis of chronic disease were included in this cross-sectional observational study. The use of 15 CAM modalities were evaluated in accordance with the Traditional and Complementary Medicine Regulations. Logistic regression analysis was further performed the association between CAM use and related factors.

Results: The mean age of 692 people in the study group was 50.6±13.6 years. In this study, the frequency of CAM use was found to be 37.1%. Univariate and age adjusted univariate logistic regression analysis performed to determine the correlation of the use of CAM practices with respect to sociodemographic variables and health-related variables revealed that being a woman, admitting to faculty of medicine, not having an income-generating job and living in an extended family were found to be positive predictors of CAM use.

Conclusion: The fact that one out of every three patients diagnosed with a chronic disease and who have admitted to a health care institution had already experienced CAM practices indicate that the orientation towards CAM practices is quite high. Further comprehensive research is necessary with regard to planning the integration of CAM practices into health services.
ANALISA POLA DATA PENYAKIT DI KLINIK GIGI RDC DENGAN MENERAPKAN METODE ASSOCIATION
Authors: Samosir Epa Prima Melina , Tukino Tukino
Published: March 2023

Health is an expensive thing, so keeping it healthy is one of our obligations. To improve health, mastery of technology must increase, and if used correctly, technology use can be steered. For this reason, technology is used to analyze a patient or a patient's disease so that the hospital or clinic can serve it well. One way to solve this problem is to search for patterns or association rules (association rules) in the database whose owner has a relationship with data mining to find specific rules. A priori algorithmic approaches can perform searches on historical data to identify data patterns based on previously identified features. In this study, the approval rating was 20% and the trust rating was 80%. Among them, support is the percentage value of the combination of complaint items in the database, and confidence is the certainty of the relationship between items in the rules generated and processed by Excel and Tanagra software. The result is consistent with the highest RDC clinical case. The base value is 12.24 and the confidence level is 80.00%. and dental consultations. Therefore, if a patient complains about dental veneers, it is likely that 80.0% of the patients will consult first
IMPLEMENTASI METODE BUSINESS PROCESS REENGINEERING (BPR) PADA SISTEM PELAYANAN DATA PENDUDUK
Authors: Arip Islahudin Muhammad , Hadikurniawati Wiwien
Published: March 2023

Kelurahan Kalimas saat ini masih menggunakan metode konvensional dalam memberikan pelayanan data penduduk sehingga proses pencatatan memakan waktu yang lama. Solusi untuk mengatasi hal tersebut ialah dengan menciptakan suatu program berbasis web yang memiliki fitur pencatatan dan pelaporan data penduduk. Dengan adanya web ini, maka pegawai tidak memerlukan buku dan microsoft word untuk melakukan pencatatan yang sifatnya terjadi dua kali. Business Process Reengineering (BPR) merupakan suatu pendekatan bisnis yang berfokus pada analisis alur kerja atau proses bisnis yang terjadi dalam suatu lembaga atau organsiasi. Penulis menerapkan metode BPR untuk mengidentifikasi alur kerja sistem yang sedang berjalan di kantor Kelurahan Kalimas dan mendapatkan gambaran untuk menciptakan aplikasi berbasis web guna membantu mempercepat proses pelayanan data penduduk di Kelurahan Kalimas. Hasil penelitian ini yaitu berupa sistem administrasi kependudukan untuk mendata SKTM, KTP, KK, Surat Kelahiran, Surat Kematian, Surat Pindah, dan Surat Pindah Datang. Pihak yang dapat menggunakan aplikasi ini yaitu pegawai kelurahan, lurah, dan admin. Aplikasi yang dihasilkan dari penelitian ini memiliki manfaat untuk mempermudah pegawai Kelurahan Kalimas dalam mengelola data kependudukan dan mempermudah lurah dapat memonitor data kependudukan Kelurahan Kalimas.
Perancangan dan Penerapan Motion Capture Pada Karakter 3D Dalam Video
Authors: Pratama Jimmy , Frenky Frenky
Published: March 2023

Perancangan dan Penerapan Motion Capture pada Karakter 3D dalam Video. Motion Capture adalah teknologi yang dapat merekam pergerakan model manusia menjadi digital 2D atau 3D secara realistis. Di Indonesia sendiri, pengguna teknologi Motion Capture masih minim peminat, factor cost sangat mahal dan ketersediaan sistem Motion Capture terbatas. Seiring berjalannya waktu, ditemukan teknologi Mocap yang lebih sederhana dan mudah digunakan oleh masyarakat umum dengan menggunakan kamera Kinect, yang memungkinkan kita menghasilkan informasi kedalaman, tekstur, pengguna, dan kerangka. Metode penelitian video animasi 3D ini menggunakan MDLC (Multimedia Development Life Cycle). Video animasi ini dibuat dengan menggunakan teknik Mocap Markerless dan aplikasi Blender 2.79b sebagai media pembuatan karakter 3D hingga ke tahap animasi 3D. Perancangan dan implementasi Motion Capture pada karakter 3D dalam video ini bertujuan untuk membuktikan dan dapat membantu pengguna Mocap memahami bagaimana merancang dan mengimplementasikan kreasi Motion Capture sederhana pada karakter 3D ke dalam video.
PENERAPAN ALGORITMA K-NEAREST NEIGHBOR DALAM KLASIFIKASI JUDUL BERITA HOAX
Authors: Hendriyanto Muhammad Diki , Sari Betha Nurina
Published: March 2023

With the rapid development of information technology, especially in Indonesia, information is more easily obtained through online media. Therefore, the dissemination of information in online media becomes uncontrollable and a lot of information is not in accordance with the facts or can be said to be a hoax. Readers should be more careful when reading news headlines to avoid hoaxes. The purpose of this research is to find out how to apply the K-Nearest Neighbor (KNN) algorithm in classifying news including hoaxes or not hoaxes. In the process, the classification of hoaxes or non-hoaxes uses the KDD method in text mining and goes through several stages, namely preprocessing, word weighting with TF-IDF and classification using the KNN algorithm. There are 3 scenarios in the data split process, namely 90:10, 80:20, and 70:30. Evaluation is done by using a confusion matrix. The results of this study obtained the highest accuracy of 93.33% with a k value of 3 in the 90:10 scenario. So, the K-Nearest Neighbor algorithm is suitable for classifying hoax news titles.
SISTEM INFORMASI PELAYANAN PENDUDUK RW 009 BOJONG PONDOK TERONG CIPAYUNG DEPOK BERBASIS JAVA
Authors: Hokyanto Nico , Suryadi Ahmad , Dwi Puspitasari Anggun Citra Dini
Published: March 2023

The purpose of this research is to design a population service information system that currently running on the RW 009  Bojong Pondok Terong Village Cipayung District Depok, from manual to based computer. In addition, this research also aims to design a population service information system at the RW 009  Bojong Pondok Terong Village Cipayung District Depok to be able to overcome the problems in data storage, be more effective in making reports, and so that data is not easily lost. The time research was carried out starting from March until July 2022. This research uses a qualitative approach by developing a system using the waterfall method. The result of this research is the application that the researcher made can make it easier to manage data in the database RW 009 Bojong Pondok Terong Village Cipayung District Depok because it is computerized and easy to use. With the application that the researcher made, the data of the residents of RW 009 Bojong Pondok Terong Village Cipayung District Depok is safer because it no longer uses paper media so there is no more risk of paper loss or tearing.
PERANCANGAN MONITORING SUHU BERBASIS INTERNET OF THINGS DENGAN NODE MCU ESP8266, DHT 11 DAN THINGSPEAK
Authors: Salam Fahrus , Alexander Onki
Published: March 2023

Monitoring temperature is an aspect that we need to know so that we can know the standard of temperature and humidity in a place. The purpose of this study is that we monitor temperature and humidity levels in real-time, so an Internet of Things (IoT) based Temperature Monitoring Design is made for DHT11 temperature and humidity sensors whose data can be acquired using the NodeMCU ESP8266 microcontroller connected to the internet or wifi. sent to ThingSpeak as the data-receiving server. After the data is entered into Thingspeak, the measurement data that has been carried out can be viewed using a cellphone or computer. The data obtained is then displayed in the form of temperature and humidity graphs, these graphic displays can be accessed online on the Thingspek web
Optimization of guanosine-based hydrogels with boric acid derivatives for enhanced long-term stability and cell survival
Authors: Merino-Gómez Maria , Godoy-Gallardo Maria , Wendner Mathias , Mateos-Timoneda Miguel A. , Gil F. Javier , Perez Roman A.
Published: March 2023

Tissue defects can lead to serious health problems and often require grafts or transplants to repair damaged soft tissues. However, these procedures can be complex and may not always be feasible due to a lack of available tissue. Hydrogels have shown potential as a replacement for tissue grafts due to their ability to support cell survival and encapsulate biomolecules such as growth factors. In particular, guanosine-based hydrogels have been explored as a potential solution, but they often exhibit limited stability which hampers their use in the biofabrication of complex grafts. To address this issue, we explored the use of borate ester chemistry and more complex boric acid derivatives to improve the stability and properties of guanosine-based hydrogels. We hypothesized that the aromatic rings in these derivatives would enhance the stability and printability of the hydrogels through added π-π stack interactions. After optimization, 13 compositions containing either 2-naphthylboronic acid or boric acid were selected. Morphology studies shows a well-defined nanofibrilar structure with good printable properties (thixotropic behaviour, print fidelity and printability). Moreover, the pH of all tested hydrogels was within the range suitable for cell viability (7.4–8.3). Nevertheless, only the boric acid-based formulations were stable for at least 7 days. Thus, our results clearly demonstrated that the presence of additional aromatic rings did actually impair the hydrogel properties. We speculate that this is due to steric hindrance caused by adjacent groups, which disrupt the correct orientation of the aromatic groups required for effective π-π stack interactions of the guanosine building block. Despite this drawback, the developed guanosine-boric acid hydrogel exhibited good thixotropic properties and was able to support cell survival, proliferation, and migration. For instance, SaOS-2 cells planted on these printed structures readily migrated into the hydrogel and showed nearly 100% cell viability after 7 days. In conclusion, our findings highlight the potential of guanosine-boric acid hydrogels as tissue engineering scaffolds that can be readily enhanced with living cells and bioactive molecules. Thus, our work represents a significant advancement towards the development of functionalized guanosine-based hydrogels.
GPS-free synchronized pseudo-random number generators for internet-of-things
Authors: Rahman Mustafizur , Chakrabartty Shantanu
Published: March 2023

Introduction

Securing wireless communications in internet-of-things (IoT) requires both generation and synchronization of random numbers in real-time. However, resource constraints on an IoT device limit the use of computationally intensive random number generators and the use of global positioning systems (GPS) for synchronization. In this paper, we propose a synchronized pseudo-random number generator (SPRNG) that uses a combination of a fast, low-complexity linear-feedback-shift-register (LFSR) based PRNG and a slow but secure, synchronized seed generator based on self-powered timers.

Methods

A prototype synchronized self-powered timer (SSPT) array was fabricated in a standard silicon process and was used to generate dynamic random seeds for the LFSR. The SSPTs use quantum-mechanical tunneling of electrons to operate without any external power and are practically secure against tampering, snooping, and side-channel attacks (both power and electromagnetic).

Results

In this work, we explore protocols to periodically and securely generate random bits using the self-powered timers for seeding the LFSR. We also show that the time-varying random seeds extend and break the LFSR periodic cycles, thus making it difficult for an attacker to predict the random output or the random seed. Using the National Institute of Standards and Technology (NIST) test suite we verify the randomness of the measured seeds from the fabricated ensemble of SSPTs together with the random bit sequences generated by a software-seeded LFSR.

Discussions

In this modality, the proposed SPRNG could be used as a trusted platform module (TPM) on IoTs and used for verifying and authenticating secure transactions (e.g., software upgrades). Since the SPRNG system does not require access to GPS for synchronization, therefore it could be used in many resource-constrained and adversarial environments.
Diagnostic performance of IVUS-FFR analysis based on generative adversarial network and bifurcation fractal law for assessing myocardial ischemia
Authors: Yong Dong , Minjie Chen , Yujie Zhao , Jianli Wang , Ze Liu , Pengfei Li , Xiangling Lai , Xiujian Liu , Javier Del Ser
Published: March 2023

Background

IVUS-based virtual FFR (IVUS-FFR) can provide additional functional assessment information to IVUS imaging for the diagnosis of coronary stenosis. IVUS image segmentation and side branch blood flow can affect the accuracy of virtual FFR. The purpose of this study was to evaluate the diagnostic performance of an IVUS-FFR analysis based on generative adversarial networks and bifurcation fractal law, using invasive FFR as a reference.

Method

In this study, a total of 108 vessels were retrospectively collected from 87 patients who underwent IVUS and invasive FFR. IVUS-FFR was performed by analysts who were blinded to invasive FFR. We evaluated the diagnostic performance and computation time of IVUS-FFR, and compared it with that of the FFR-branch (considering side branch blood flow by manually extending the side branch from the bifurcation ostia). We also compared the effects of three bifurcation fractal laws on the accuracy of IVUS-FFR.

Result

The diagnostic accuracy, sensitivity, and specificity for IVUS-FFR to identify invasive FFR≤0.80 were 90.7% (95% CI, 83.6–95.5), 89.7% (95% CI, 78.8–96.1), 92.0% (95% CI, 80.8–97.8), respectively. A good correlation and agreement between IVUS-FFR and invasive FFR were observed. And the average computation time of IVUS-FFR was shorter than that of FFR-branch. In addition to this, we also observe that the HK model is the most accurate among the three bifurcation fractal laws.

Conclusion

Our proposed IVUS-FFR analysis correlates and agrees well with invasive FFR and shows good diagnostic performance. Compared with FFR-branch, IVUS-FFR has the same level of diagnostic performance with significantly lower computation time.
The apparent focal depth, emergence angle, and take-off angle of seismic wave measured by YRY-4-type borehole strainmeter as one kind of strain seismograph
Authors: Tang Lei , Qiu Zehua , Fan Junyi , Yin Zhigang
Published: March 2023

Introduction: In theory, the observation objects and principles of strain seismograph and traditional pendulum seismograph are different, and the characteristics of observed signals should also be dissimilar. The observation results of pendulum seismograph show that seismic waves in inhomogeneous media will undergo refraction, reflection, and attenuation. Then, what signal characteristics can be detected by strain seismograph is great significance for understanding and explaining the observation results.

Methods: Using YRY-4 type four-gauge borehole strainmeter as one kind of strain seismograph to detect the strain tensor change of the plane seismic wave emitted from the surface, a five-site strain seismograph observation network was built in Shanxi Province, with continuous observation for 2 years at a sampling rate of 100 Hz. In this paper, two local events occurring in the area covered by the strain seismograph observation network are taken as examples. We systematically studied the characteristics of seismic wave signals recorded by strain seismographs at five sites, inverted for the focal depth of the two local earthquakes and the relationship between the wave velocity and the wave velocity gradient of the focal depth, and calculated the apparent focal depth, the emergence angle and the take-off angle of seismic waves.

Results: These results show stable uniqueness and apparent regularity, especially since the inverted focal depths are basically consistent with the seismic solutions based on those traditional pendulum seismographs. The observations from this study show that the strain seismograph can be used as an effective supplement to the pendulum seismograph.

Discussion: In the future, we will continue to study the rupture process and focal mechanism of moderate-strong earthquakes and teleseismic earthquakes by combining two kinds of observations.
Atomic structure and physical properties of peridotite glasses at 1 bar
Authors: Le Losq Charles , Sossi Paolo A.
Published: March 2023

Earth’s mantle, whose bulk composition is broadly peridotitic, likely experienced periods of extensive melting in its early history that formed magma oceans and led to its differentiation and formation of an atmosphere. However, the physical behaviour of magma oceans is poorly understood, as the high liquidus temperatures and rapid quench rates required to preserve peridotite liquids as glasses have so far limited their investigation. In order to better characterize the atomic structure and estimate the physical properties of such glasses, we examined the Raman spectra of quenched peridotite melts, equilibrated at 1900 °C ± 50 °C at ambient pressure under different oxygen fugacities (fO2), from 1.9 log units below to 6.0 log units above the Iron-Wüstite buffer. Fitting the spectra with Gaussian components assigned to different molecular entities (Q-species) permits extraction of the mean state of polymerisation of the glass. We find that the proportions of Q1 (0.36–0.32), Q2 (0.50–0.43), and Q3 (0.16–0.23) vary with Fe3+/FeTOT (FeTOT = Fe2+ + Fe3+), where increasing Fe3+/FeTOT produces an increase in Q3 at the expense of Q2 at near-constant Q1. To account for the offset between Raman-derived NBO/T (2.06–2.27) with those determined by assuming Fe2+ exists entirely as a network modifier and Fe3+ a network former (2.10–2.44), ∼2/3 of the ferric iron and ∼90% of the ferrous iron in peridotite glasses must behave as network modifiers. We employ a deep neural network model, trained to predict alkali and alkaline-earth aluminosilicate melts properties, to observe how small variations in the atomic structure of peridotite-like melts affect their viscosity. For Fe-free peridotite-like melts, the model yields a viscosity of ∼ −1.75 log Pa s at 2000 °C, similar to experimental determinations for iron-bearing peridotite melts. The model predicts that changes in the peridotite melt atomic structure with Fe3+/FeTOT yield variations in melt viscosity lower than 0.1 log Pa s, barely affecting the Rayleigh number. Therefore, at the high temperatures typical of magma oceans, at least at 1 bar, small changes in melt structure from variations in oxidation state are unlikely to affect magma ocean fluid dynamics.
Summer extreme consecutive dry days over Northeast China in the changing climate: Observed features and projected future changes based on CESM-LE
Authors: Sun Yankun , Wang Yufan , Zhang Mengqi , Zeng Zixuan
Published: March 2023

Northeast China (NEC) is a major crop base in East Asia, and summer drought is one of the climate extremes that significantly influences NEC agricultural production. Therefore, understanding the response of NEC summer drought to global warming is of significance. In this study, based on observation and large-ensemble simulations of the Community Earth System Model (CESM-LE), the variabilities in summer extreme consecutive dry days (CDDs) over NEC are investigated in the present and future climate. In the observation, the NEC summer extreme CDDs showed an increasing trend during the past half century and experienced a significant interdecadal change around the middle 1990s, which is mainly due to the change in the anticyclone over Lake Baikal-Northeast Asia. The anticyclone-related anomalous downward motion and moisture divergence provided favorable conditions for increased summer CDDs over NEC. The CESM-LE multimember ensemble (MME) simulation could reproduce the change in NEC summer extreme CDDs and its related atmospheric circulations, indicating that the observed change in NEC summer extreme CDDs could be largely contributed by anthropogenic forcing. In the future warmer climate, the NEC summer extreme CDDs are projected to show interdecadal variability, which increase by approximately 6.7% in the early 21st century (2020–2030), then decrease by approximately 0.3% in the middle to late 21st century (2040–2080), and further increase by approximately 2.1% in the late 21st century (2085–2100). In addition, the projected changes in the anticyclone over Lake Baikal-Northeast Asia show a similar feature to that of the NEC summer extreme CDDs, which might further provide some confidence in the projection of the NEC summer extreme CDDs due to the physical connection between CDDs and anticyclone in the future.
Geologic controls on the genesis of the Arctic permafrost and sub-permafrost methane hydrate-bearing system in the Beaufort–Mackenzie Delta
Authors: Li Zhen , Chabab Elena , Spangenberg Erik , Schicks Judith M. , Kempka Thomas
Published: March 2023

The Canadian Mackenzie Delta exhibits a high volume of proven sub-permafrost gas hydrates that naturally trap a significant amount of deep-sourced thermogenic methane (CH4) at the Mallik site. The present study aims to validate the proposed Arctic sub-permafrost gas hydrate formation mechanism, implying that CH4-rich fluids were vertically transported from deep overpressurized zones via geologic fault systems and formed the present-day observed GH deposit since the Late Pleistocene. Given this hypothesis, the coastal permafrost began to form since the early Pleistocene sea-level retreat, steadily increasing in thickness until 1 Million years (Ma) ago. Data from well logs and 2D seismic profiles were digitized to establish the first field-scale static geologic 3D model of the Mallik site, and to comprehensively study the genesis of the permafrost and its associated GH system. The implemented 3D model considers the spatially heterogeneously distributed hydraulic properties of the individual lithologies at the Mallik site. Simulations using a proven thermo-hydro-chemical numerical framework were employed to gain insights into the hydrogeologic role of the regional fault systems in view of the CH4-rich fluid migration and the geologic controls on the spatial extent of the sub-permafrost GH accumulations during the past 1 Ma. For >87% of the Mallik well sections, the predicted permafrost thickness deviates from the observations by less than 0.8%, which validates the general model implementation. The simulated ice-bearing permafrost and GH interval thicknesses as well as sub-permafrost temperature profiles are consistent with the respective field observations, confirming our introduced hypothesis. The spatial distribution of GHs is a result of the comprehensive interaction between various processes, including the source-gas generation rate, subsurface temperature, and the hydraulic properties of the structural geologic features. Overall, the good agreement between simulations and observations demonstrates that the present study provides a valid representation of the geologic controls driving the complex permafrost-GH system. The model’s applicability for the prediction of GH deposits in permafrost settings in terms of their thicknesses and saturations can provide relevant contributions to future GH exploration and exploitation.
Evaluation of petrophysical classification of strongly heterogeneous reservoirs based on the MRGC algorithm
Authors: Zhao Xiaoqing , Miao Quansheng , Zhao Ruipu , Liang Xu , Wang Xiabin , Tian Tengfei
Published: March 2023

The target formation in the study area of the Pearl River Mouth Basin is characterized by complex lithology and thin interbedded layers, with a large pore-permeability distribution range and strongly heterogeneous characteristics, which makes the reservoir pore structure and production capacity significantly different and brings research difficulties for reservoir logging evaluation and desert identification. The conventional reservoir classification method is mainly based on physical research, which requires developing extremely accurate formulas for calculating porosity and permeability; the calculation accuracy of pore permeability of low-porosity and low-permeability reservoirs is difficult to guarantee; and the conventional logging data cannot be comprehensively applied in reservoir classification. In this paper, taking Zhujiang and Zhuhai Formation reservoirs in the Huizhou M oilfield as an example, we integrated core analysis data such as core cast thin section, pore permeability data, rock electrical parameters, grain size, and relative permeability curves and combined with petrophysical parameters and pore structure characteristics to classify the reservoirs. The artificial neural network is used to predict the resistivity of saturated pure water (R0) to remove the influence of oil and gas on reservoir resistivity. The natural gamma ray (GR) “fluctuation” is used to calculate the variance root of variation (GS) to reflect the lithological variability and sedimentary heterogeneity of the reservoir, and then the conventional logging preferences, R0and Gs (based on GR), are classified based on the automatic clustering MRGC algorithm to classify the logging facies. To classify the petrophysical phase reservoirs under the constraint of pore structure classification, we proposed a petrophysical classification logging model based on the natural gamma curve “fluctuation” intensity for strongly heterogeneous reservoirs. The learning model is extended to the whole area for training and prediction of desert identification, and the prediction results of the model are in good agreement with the actual results, which is important for determining favorable reservoirs in the area and the adjustment of oilfield development measures.
Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial
Authors: Rostami Sahar , Alyasin Ashraf , Saedi Mojtaba , Nekoonam Saeid , Khodarahmian Mahshad , Moeini Ashraf , Amidi Fardin
Published: March 2023

Purpose

In a randomized, triple-blind, placebo-controlled clinical trial (RCT) including 50 infertile women with endometriosis candidate for assisted reproductive techniques (ART), we studied the effect of Astaxanthin (AST) on pro-inflammatory cytokines, oxidative stress (OS) markers, and early pregnancy outcomes.

Methods

Before and after 12 weeks of AST treatment (6 mg per day), blood serum and follicular fluid (FF) samples were collected from 50 infertile women with endometriosis stage III/IV undergoing ART. Pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and OS markers (malondialdehyde [MDA], superoxide dismutase [SOD], catalase [CAT], and total antioxidant capacity [TAC]) were measured in the serum and FF. ART outcomes were also compared between the groups.

Results

Increased serum levels of TAC (398.661 ± 57.686 vs. 364.746 ± 51.569; P = 0.004) and SOD (13.458 ± 7.276 vs. 9.040 ± 5.155; P = 0.010) were observed after AST therapy in the treatment group. Furthermore, serum MDA (14.619 ± 2.505 vs. 15.939 ± 1.512; P = 0.031) decreased significantly following antioxidant treatment. In addition, significantly lower serum levels of IL-1β (4.515 ± 0.907 vs. 6.8760 ± 0.8478; P = 0.000), IL-6 (5.516 ± 0.646 vs. 5.0543 ± 0.709; P = 0.024) and TNF-α (2.520 ± 0.525 vs. 2.968 ± 0.548; P = 0.038) were observed after AST treatment. In addition, AST supplementation led to an improved number of oocytes retrieved (14.60 ± 7.79 vs. 9.84 ± 6.44; P = 0.043), number of mature (MII) oocytes (10.48 ± 6.665 vs. 6.72 ± 4.3; P = 0.041), and high-quality embryos (4.52 ± 2.41 vs. 2.72 ± 2.40; P = 0.024).

Conclusion

AST pretreatment can modulate inflammation and OS in endometriosis-induced infertile patients. ART outcomes also improved after 12 weeks of AST therapy. Our results suggest that AST can be a potential therapeutic target for infertile patients with endometriosis undergoing ART.
All together now: Cellular and molecular aspects of leaf development in lycophytes, ferns, and seed plants
Authors: Romanova Marina A. , Domashkina Valentina V. , Maksimova Anastasiia I. , Pawlowski Katharina , Voitsekhovskaja Olga V.
Published: March 2023

Recent advances in plant developmental genetics together with rapid accumulation of transcriptomic data on plants from divergent lineages provide an exciting opportunity to explore the evolution of plant morphology. To understand leaf origin in sporophytes of land plants, we have combined the available molecular and structural data on development of leaves with different morphologies in different plant lineages: clubmosses, spikemosses, leptosporangiate ferns, ophioglossioid ferns, marattioid ferns, whisk ferns, horsetails, and conifers. Specifically, we address the peculiarities of proximo-distal, ad/abaxial, and lateral development; presence/absence of mesophyll differentiation into palisade and spongy parenchyma; and type of leaf vascular bundles (collateral and bicollateral). Furthermore, taxon-specific and morphology-specific features of leaf development are considered in the context of the organization of shoot apical meristems (SAMs)—monoplex, simplex, or duplex—that produce leaf primordia. The data available imply that cellular patterns of leaf initiation correlate strongly with the structure of the SAMs but not with further leaf development or morphology. The later stages of leaf development are neither correlated with SAM structure nor with taxonomy. Occurrence and, if available, patterns of expression of homologs of the angiosperm genes responsible for the development of adaxial (ARPandC3HDZ) and abaxial (YABBYandKANADI) leaf domains, or establishment of the leaf marginal meristem (WOX) are discussed. We show that there is no correlation in the set of homologs of TFs that regulate abaxial and adaxial leaf domain development between leaves containing only spongy and no palisade mesophyll (of spikemosses, clubmosses, whisk ferns, horsetails, and most conifers), and leaves differentiated into palisade and spongy mesophyll (of leptosporangiate ferns,Ginkgo,Gnetum, and angiosperms). Expression of three out of four regulators of leaf development in primordia of both leaves and sporangia—C3HDZin spikemosses and whisk ferns,YABBYin clubmosses andKANADIin spikemosses and horsetails—indicates that a sporangium developmental program could have been co-opted as a “precursor program” for the origin of microphylls and euphylls. Additionally, expression of leaf development regulators in SAMs of spikemosses (ARP,C3HDZ, andKANADI), clubmosses (YABBY), leptosporangiate ferns (C3HDZ), and horsetails (C3HDZandKANADI) indicates that at least some mechanisms of SAM regulation were co-opted as well in the pre-program of leaf precursors.