bluuebunny/crossref_metadata_2025 huggingface dataset:
On the issue of axiological aspects of medicine: attempt of sociological essay
Authors: Mettini E.
Published: October 2020

The analyzed issue presupposes develo0ment of the new scientific paradigm to implement true communication of physician and patient without formalism or structural power in the process of communication. According to author, to rearrange this type of social interaction of physician and patient from the position of axiological i.e. valueoriented approach that includes eventness and discourse-ethics as modes of its implementation. The overcoming of statistical communication in favor of dynamic one can serve as a base for identification of new theoretical and methodical guideline in this area transforming relationship between physician and patient into system of couching.
The sociology of medicine: vectors of scientific search (according to results of conference)
Authors: Prisiajnaia N. V , Pavlov S. V
Published: October 2020

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The communicative approach in modern practices of health preservation as exemplified by schools of health
Authors: Andrianov S. V , Tchernishkov D. V
Published: October 2020

The analysis of possibility of applying communicative approach to investigation of institutionalized practices of health preservation within the framework of sociology of medicine considering new paradigm of 4P-medicine is presented. The health preservation is determined as a process of preservation and promotion of health requiring increasing of value attitude to one self's health and health of one's people on the basis of awareness of personal responsibility. The interpretation of health preservation is possible at the level of macro- and micro-processes. In the last case, the complex of subjective processes is involved permitting to implement analysis with application of phenomenological tradition and tradition of social engineering significantly enhancing research perspectives of development of modern practices of health preservation.
Some aspects of development of typhoid fever and persistent brucellosis infection
Authors: Bojchenko Marina N. , Kravtsova Elena O. , Budanova Elena V. , Belaia Olga F. , Maloletneva Natalya V. , Umbetova Karina T.
Published: October 2020

Bacterial vacuolated intracellular parasites, such as Salmonella spp. and Brucella spp., possess the ability to cause persistent, long-life chronic infection during which the microbe continues to replicate inside the host organism in spite of the development of an immune response. Such bacteria develop a strategy to evade the immune response, which plays a key role in the development of chronic infection. The implementation of this strategy is aimed at inhibiting the action of factors of innate immunity. In brucella, this process is mediated by the noncanonical structure of lipopolysaccharide (LPS), as a result of which the pathogen is not recognized by the cells of innate immunity, as well as by the functioning of T4CC, the effector proteins of which block the development of the inflammatory response. The strategy of S. Typhi is realized via the expression of genes of pathogenicity island 7 encoding Vi-antigen and genotoxin. Vi-antigen inhibits recognition of the microbe by cells of the innate immune system. Typhoid genotoxin causes the death of immune cells. Brucella realizes this strategy via the noncanonical structure of LPS and T4SS, effector proteins of which block the development of inflammation. Alternative activated macrophages appear during chronic infection caused by both pathogens. These microbes are able to regulate the metabolism of macrophages according to their needs while persisting in them. A review of the sources of information on this problem allows us to conclude that both the causative agent of typhoid fever S. Typhi and the causative agents of brucellosis use the same strategies for the development of a chronic infectious process, but the implementation of these strategies is carried out specifically.
Meningoencephalitis case with listeriosis etiology in an immunocompetent female patient
Authors: Domashenko Olga N. , Gridasov Vitaliy A.
Published: October 2020

Nervous forms of listeriosis are observed in 5%10% of persons suffering from this disease and in 75% of children with bacteriologically confirmed listeriosis as well. The most widespread clinical variant is Listeria meningitis, making up 15% of all cases of bacterial and serous meningitides. The mortality rate at neurolisteriosis reaches 30%40%. A case of acute meningoencephalitis associated with Listeria monocytogenes 4b in a 37-year-old immunocompetent woman is described. The disease was characterized by subacute onset, manifested intoxication, long-lasting and high-grade fever, cerebral coma, bulbar syndrome, right-side hemiparesis, bilateral hypertonus of the wrist flexors, strabism, anisocoria, manifested leukocytosis with leukocyte formula stab shift, ESR 4559 mm/hour. Cerebrospinal fluid test: cytosis 663 сells in 1 mcl, neutrophils 79%, lymphocytes 21%, protein 1451 mg/l, glucose 3.8 mmol/l. Diagnosis had been confirmed with detection of IgM against Listeria monocytogenes 4b in liquor using the indirect immunofluorescence reaction and Listeria monocytogenes by means of PCR. Antibacterial therapy had been conducted using Meropenem, Ampicillinum, endolumbal administration of 4 mg once daily of Gentamycinum combined with intravenous administration of 24 million of units/day of Penicillin. On day 50, she was transferred for rehabilitation treatment to the Department of Neurology.
Heterogeneity of Salmonella isolates obtained from various sources in Russia 2010–2019
Authors: Rozhnova Sofia Sh. , Kuleshov Konstantin V. , Pavlova Anastasia S. , Guseva Anna N. , Kozhakhmetova Tatiana A. , Akulova Nadezhda K. , Podkolzin Alexander T.
Published: October 2020

Aim: the goal of the study was to evaluate the heterogeneity of the Salmonella enterica subsp. enterica strains isolated from clinical specimens and various environmental sources in the Russian Federation during the period 20112019.
Materials and methods. The data of 3076 non-typhoid isolates of Salmonella obtained from sporadic and outbreak cases of salmonellosis (n = 2518), food and water samples (n = 558) were used. These isolates were serotyped according to the KaufmanWhite scheme and genotyped by Pulsed-Field Gel Electrophoresis (PFGE) using XbaI and BlnI restriction endonucleases according to a standard PFGE-protocol developed by PulseNet International Network.
Results. The studied Salmonella isolates were differentiated into 73 serotypes and 601 PFGE types. A comparative analysis of isolates from various sources made it possible to identify subtypes that differed significantly in their prevalence in humans and potential transmission factors (sources). A significant proportion of chicken, turkey, and pork meat samples contained PFGE-subtypes which did not occur in clinical samples. Regional differences in the heterogeneity of the Salmonella spp. were also identified.
Conclusions. Genetic heterogeneity of the Salmonella population from humans and other sources shows significant variability of virulent properties and indicates the necessity of differentiated assessment of their epidemiological potential.
Primary squamous epithelial cancer (cancroid) of the uterine cavity
Authors: Zabolotsky A. P.
Published: October 2020

Literary data on the location of the flat epithelium in the cavity of the body of the uterus are very scarce and are limited to only a few articles that interpret the atypical location of the flat epithelium or in inflammatory processes of the uterus, or in cancers of the uterus.Among the works dealing with the question of finding flat epithelium in inflammatory processes of the body of the uterus should be attributed to the work of Zeller, which appeared in 1884.In the number of works treating flat epithelial cancer of the body of the uterus, we have the reports of Piering and Gebhardt.
A. A. Muratov. - To the question of sarcoma transplantation to the healthy part of the body in the same patient. (Yezhenedelnik, 1895, No. 15)
Authors: Kakushkin N.
Published: October 2020

Cases of self-infection with cancer are described by Sippel. The author describes a case of self-infection with sarcoma. Dressmaker, 14 years old; complaints of severe constant pain in the lower abdomen. Recognized the neoplasm of common Fallopian tubes, or ovaries, probably of a sarcomatous nature. Gluttony showed that the tumor, extensively fused with the surrounding organs, belongs to the right appendage. When it was separated, part of its clumpy-purulent contents poured out into the abdominal cavity. The entire tumor was removed and, carefully examined, turned out to be a round-large-cell sarcoma, containing parts of fusiform cells in places.
F.A. Stefanis. - A case of dual deformity. (Universitetskíya Izvestiya, Kiev, 1895, No. 3)
Authors: Kakushkin N.
Published: October 2020

A multiparous Moldavian woman, 30 years old, gave birth to a child with two heads, two completely separate necks, a common torso, with double external male genitals, with four upper and two lower limbs, hence, a freak, which should be called dicephalus tetrabrachius masculinus. The birth lasted 15 hours.
V. V. Tipyakov. — Two cases of cysts of the round uterine ligament. - (Medical Review, 1895, No. 13)
Authors: Kakushkin N.
Published: October 2020

1st case: peasant woman 24 y. A tumor in the region of the right inguinal canal, about the size of a goose egg, soft-elastic, not decreasing under pressure, not moving away from the place and not guided into the inguinal canal, which also cannot be penetrated with a finger.
N. Thomson. - Beiträge zur Extrauteringravidität. (Zeitschr. F. Geb. Und Gyn., Bd. XXXII, Hft. 1). To the casuistry of ectopic pregnancy
Authors: Khazan S. Y.
Published: October 2020

1) A severely emaciated multiparous woman, who had the last regulation 8 months ago, complains of pain, and lately on bleeding. Due to the undetermined nature of the tumor felt in the abdomen, the diagnosis fluctuates between missed labor and gravidatas extrauterina. Probing the uterus, which turned out to be empty, raises doubts. But earlier, after the consent of the patient, who was in a very feverish state, at the proposed surgical intervention, a stinking amniotic fluid began to seep through a small opening in the vagina. Having widened this hole, we began to extract the contents of the fertile beetle, which did not end immediately, but lasted for several days at intervals. Convalescence.
Dr. J. A. Hamilton, (surgeon, gynecological department, hospital in Adelaide, Australia). - A case of intra-peritoneal Haematocele. - (Australasian Med. Gaz., 1894, 15 / XII, p. 377). Intraperitoneal hemorrhage
Authors: Ginzburg M.
Published: October 2020

A., 26 years old, gave birth a year ago and was healthy. There were no expected regulations in the July; at the beginning of August, not wanting to be pregnant, she continued a series of gymnastic tricks and on 7 / VIII, she really had a little blood with the pain, which intensified and made her go to bed. 17 / VIII when examining it: the uterus in anteflexio, not enlarged: a tumor, the size of an orange, occupying the Douglas space, of an elastic consistency is observed to the left. Small blood, pain of a spasmodic nature, spreading to the anus. 19 / VIII due to increased pain - the second study under anesthesia with ether, did not indicate anything new. 20 / VIII - operation.
Dr. A. Rabogliati (Bradford). - On some symptoms, which stimulate Disease of the Pelvic Organs in Women, and their Treatment. - (The British Medic. Journ., 1895, 12 / i, p. 67). - About some seizures that simulate diseases of the pelvic organs in women and the scope of their treatment
Authors: Ginzburg M.
Published: October 2020

Women, both virgins and giving birth, complain of pain in the lumbar, ileal and groin areas, fatigue, headaches; in bed, the pains are weak, but do not go away completely; during and immediately after menstruation, the pain worsens. The study indicates a slight contraction of the uterus; in the last days, as well as in its appendages, they do not find other changes. Doctors diagnose this condition as general nervousness, neurasthenia, colic (intestinal? Ref.); others consider it oophoritis, salpingitom. The patients pass from one doctor to another and finally agree to castration, which does not help them at all. Rabagliati cut out in such cases a piece of the abdominal integument and peritoneum in the navel area and achieved some improvement.
Billiteri. - Two congenital cases of Roberts pelvis.- (Teratologia, 1895, april, p. 125) .- Two cases of transversely narrowed pelvis of congenital origin
Authors: Ginzburg M.
Published: October 2020

The named anomaly was observed in 2 sisters, which is why Ballantine admits that she was congenital to them.
The volume of changes in the nerve cells of the intervertebral nodes in the active state
Authors: Kovalevsky V.
Published: October 2020

The Nissl method showed that every nerve cell consists of two substances: the main one, which does not stain with this treatment, and the other, interspersed with the first, having a selective affinity for the main aniline dyes. The type, method of distribution in the nerve cell of this chromophilic substance is different depending on the nature of the group to which this nerve cell belongs. Most often, this substance is in the form of grains, differing in an extreme variety of size and shape. This new word in the study of the structure of the nerve cell gave, together with the darkness, a new basis for the study of the issue of changes in the nervous cells in the active state. Thanks to this, a number of studies by authors appeared, such as Hodge, Vas, Mann, Lambert, Lugaro, Levi, Valensa, Magini, whose purpose was to answer the question whether the nerve cells change during activity, and if they change, then what are these changes, which is, consequently, the histological picture of the process of excitation of the nerve cell. To regret, the data, which appeared to answer this question, disagree with each other. In fact, the size of the calm nerve cells, decreasing with irritation, according to Hodge, increases according to Vas and according to Lambert's opinion, they remain without changes. Chromophiles according to Vas and Lambert, moving into an irritated cell to the periphery, according to the opinion of the other authors, do not change their position. The amount of nuclear chromatin increasing along Vas decreases according to Mann. Also contradictory data and volume of changes in the size of the nucleus and nucleolus. Only one thing is that all researchers agree, this is that neither the size nor the number of chromophiles change during the appearance of irritation of the nerve cell. True, Mann says that during rest, various coloring substances accumulate in the cell, which are then consumed during activity, but this indication does not seem to refer to chromophiles, but to the chromatin of the nucleus.
About alcoholic automatism
Authors: Kuznetsov V. P.
Published: October 2020

The painful condition, known in medicine under the name of alcoholic automatism, alcoholic trance, alcoholic somnambulism, despite its significance in forensic medicine, has been the subject of research from a relatively recent time. In 1878, the observations related to this were described by Professor Magnan, who expressed the proposition that alcoholic automatism is the result of the complication of alcoholism with epilepsy and that automatic states are observed only in such chronic alcoholics who have epilepsy. Since 1879, several papers by Dr. Crothers have been published on this issue. Further cases of alcoholic automatism have been described by Drs. Kinney, Collin, Chamtemesse, Souques and others.
Prof. I. A. Sikorskiy. Epidemic free deaths and murders in Ternovsky farms (near Tiraspol). - Questions of neuropsychic medicine. T. II, no. 3.1897
Authors: Vorotynskiy B. I.
Published: October 2020

Everyone knows the terrible drama that played out among the sectarians of the Ternovsky farmsteads: 25 people were subsequently (in groups) buried alive, dying to die a free death. This terrible Ternovo event is in our time an unprecedented fact, deserving a deep and comprehensive study. The extreme fermentation that led the sectarians to such a gloomy denouement should equally interest the historian, psychologist, forensic scientist and doctor - psychiatrist: each of them will find in this everyday drama a rich material for their scientific research.
Nissl. Die Hypothese der specifischen Nervensellenfundion. (Allg. Zeitschr. f. Psychiat. Bd. 54. pg. 1—107)
Authors: Idelson G.
Published: October 2020

It is known that Nissle managed to use alcohol for compaction and by a simple staining method to prove a special structure in the nervous cells, unknown until then, opening new horizons in the histopathology of the nervous system. The old method of condensation by means of chromic acid artificially alters the nerve lumen and therefore is not applicable to the study of the structure of cells.
On generalized Mersenne hybrid numbers
Authors: Szynal-Liana Anetta , Włoch Iwona
Published: October 2020

The hybrid numbers are generalization of complex, hyperbolic and dual numbers. In this paper we consider  a special kind of hybrid numbers, namely the Mersenne hybrid numbers and we give some of their properties.
The changing patterns of liver cancer in Saudi Arabia over a 22-year period
Authors: Alshehri Bandar M.
Published: October 2020

Background: Liver cancer is a major public health problem in the developing world. It is the sixth most common cancer in the developed world and the second leading cause of death among cancer patients, globally. This study evaluated the trends and geographical distributions of liver cancer in the Saudi Arabian population.Methods: A secondary data analysis was performed on liver cancer cases registered in the Saudi Cancer registry for the period 1994 to 2015. In all, 8,785 liver cancer cases were included in the analysis, all of them Saudi nationals.Results: There were significant decreases in the mean age-standardised rates of liver cancer over the study period. The incidence of liver cancer varied by region. A strong positive correlation was observed between liver cancer incidence and age. Hepatocellular carcinoma-NOS is the most common histopathology subtype among the Saudi population.Conclusions: The overall trend of the liver cancer age-standardised rate for males and females decreased among the Saudi population. This rate varies by region. Studying this variation in more detail will help improve public health policy, optimise distribution of resources and allocation of funding for research on prevention and diagnosis and direct awareness programs to the regions that are most in need.
Efficacy of short term versus long term antibiotic therapy in preventing deep wound infections in elective orthopaedic surgeries
Authors: Chandrakar Saurabh , Mittal Ankit , Jain Jalaz , Bansal Himanshu , Ahlawat Prateek , Sangwan S. S. , Sharma Rakesh , Arora Hitanshi
Published: October 2020

Background: Comparison of the efficacy of short term (up to 48 hours) versus long term (five days) antibiotic therapy in preventing deep wound infections in elective orthopaedic surgeries.

Methods: Two hundred patients of all ages and both sexes were divided into two groups of 100 patients. One group received long term antibiotic treatment consisting of 2 days intra-venous cefoperazone sulbactam 1.5 gm twice daily and intra-venous amikacin 500 mg twice daily followed by 3 days of oral amoxicillin clavulunate 625 mg thrice daily. Other group received short term antibiotic of 2 days intra-venous cefoperazone sulbactam 1.5 gm twice daily and intra-venous amikacin 500 mg twice daily. Comparison of SSI was done with age, sex, BMI, pre-operative haemoglobin, TLC, duration of surgery in both the groups.

Results: In group I and group II respectively, average duration of surgery in procedures involving implants was 65.02±27.41 and 59.47±20.27 minutes and non implant related procedures was 53.66±23.97 and 53.74±22.40 minutes. Overall incidence of SSI in Group I and Group II was 14% and 10% respectively. Mean infection in the present study was 12%.

Conclusions: It was concluded that in clean orthopaedic elective surgeries short term antibiotics regimen is as effective as long term antibiotics regimen. Continuing antibiotics for more than two days is associated with drug related complications like allergic reactions and gastrointestinal upset, adverse interactions in other drugs, development of resistant organisms and it adds to overall cost of treatment.
The prevalence of hyperuricemia and its associated risk factors in patients presenting with joint pain in Karachi
Authors: Muzzammil Muhammad , Qadir Abdul , Mughal Ayesha , Effendi Jahazeb , Minhas Muhammad Saeed , Jahanzeb Syed
Published: October 2020

Background: To determine the prevalence and association of hyperuricemia with genetic factors, dietary and alcohol consumption, metabolic syndrome, diuretic use and chronic renal disease in patients presenting with joint pain in the outpatient department (OPD) at a tertiary care hospital of Karachi, Pakistan and to establish a significant correlation between concentration of serum creatinine and triglyceride with uric acid concentration statistically.

Methods: This study was conducted on 2200 patients. The data included age, gender, occupation, genetic factors (family history), dietary and alcohol consumption, metabolic syndrome, hypertension, obesity, diuretic use and chronic renal disease. Serum uric acid concentration of 2.4-6.0 mg/dl (female) and 3.4-7.0 mg/dl (male) labelled as normal values. All participants’ serum uric acid concentration compared with serum creatinine and triglyceride concentration.

Results: Overall prevalence of 30.1% (662 patients) hyperuricemia in patients presenting with joint pain. Majority of the patients belonged to age group 30-34 and highest average uric acid value (7.7±2.01) was found to be in the age group of 65 and above. Hyperuricemia was related to increased age (56.25%), genetic factors 159 (24.01%), dietary 370 (55.89%) and alcohol consumption 33 (4.98%), metabolic syndrome (hypertension 146 (22.05%), obesity 121 (18.27%), diuretic use 215 (32.47%) and chronic renal disease 53 (8.00%). On laboratory investigations, hyperuricemia was directly related to serum creatinine and triglyceride.

Conclusions: This study emphasized the high prevalence of hyperuricemia in patients presenting with joint pain and it is directly proportional to the age. Increased serum uric acid levels with increasing age might be secondary to impaired renal function, use of diuretics, and hypertension as commonly seen among elderly patients. Early diagnosis, management of risk factors and treatment will prevent adverse effects on health.

 
Functional outcome of patients treated with proximal humeral internal locking osteosynthesis plate in proximal humeral fractures
Authors: Jacob Tigy Thomas , Nayak Manmatha
Published: October 2020

Background: Displaced or unstable proximal humeral fractures fare poorly with non-operative treatment. These are better treated with surgical intervention in order to prevent minimal displacement of tuberosity or articular surface from compromising the long term articular function. The objective was to assess the functional outcome of patients treated with PHILOS (the proximal humeral internal locking osteosynthesis) plate in proximal humerus fracture.

Methods: 42 patients age group range between 20 and 80 years 61.9% are male and 38.1% are female treated with philos plate. Functional outcome measured by using Constant and Murley score.

Results: 50% were Neer two part fractures, 35.7%, three part fractures, 14.3%, four part fractures. After 6 month follow up functional outcome assessed by using constant and Murley score. Excellent outcome in 1 (2.4%) good outcome in 13 (31%), fair outcome in 19 (45.2%) and poor outcome in 9 (21.4%) noted.

Conclusions: PHILOS plate fixation of proximal humerus fracture is an effective surgical technique in maintaining stability of fractures and there is significant improvement in functional outcome.
Transolecranon fracture-dislocations of the elbow: a case series of 15 patients
Authors: Lemsanni Meryem , Najeb Youssef , Chafik Rachid , Madhar Mohamed , Haoury Hanane El
Published: October 2020

Transolecranon fracture-dislocations are rare, misdiagnosed, and challenging traumatic injuries. Consensually, they are managed surgically to restore a mobile, stable and painless elbow joint. There is a relative paucity of studies on this subject in the literature. The purpose of this case series was to establish the epidemiological profile and to describe clinical, radiological, therapeutic and outcome characteristics of these lesions. Between 2007 and 2016, fifteen patients with median age of 36 years (18-65 years) presented to us with transolecranon fracture-dislocations. They were treated surgically and followed regularly with a mean follow-up of 46 months. The cause in the majority of cases was high-energy trauma, mainly traffic accidents (80%). Proximal ulna fractures were comminuted in 12 patients (80%) and open in three cases (25%). Open reduction and internal fixation with 3.5 mm reconstruction plates through a posterior approach was used in all cases. During follow up, one patient (6%) had developed wound infection with skin necrosis which was successfully managed by antibiotics and controlled wound healing. Solid osseous union was confirmed for all fractures with an average of 13.5 weeks. At final follow-up, 14 patients (93%) reported excellent outcome with a mean Broberg and Morrey score (BMS) of 86.3. Although rare, transolecranon fracture-dislocations found in patients hospitalized in a high-complexity service occurred in young men who were involved in motor vehicle accidents. These injuries can be treated successfully with reconstruction plate through a posterior approach to achieve and maintain anatomical reduction by rigid internal fixation, which is essential for promoting early rehabilitation.
A clinical study of primary cutaneous localized amyloidosis
Authors: Chapalamadugu Sahithi , Rao A. Vijaymohan
Published: October 2020

Background: Amyloidosis refers to abnormal extracellular tissue deposition of one of the biochemically unrelated proteins that share certain characteristic staining properties such as apple green birefringence of congo red stained preparations under polarized light. Amyloid deposition may occur in many organs of the body (systemic amyloidosis) or may be restricted to one tissue site (localized amyloidosis).

Methods: Observational study was conducted in the Department of Dermatology, Narayana Medical College and Hospital, Nellore. In this study of 70 patients a complete history and clinical data was taken including details of presenting complaints, age, site, duration, course of the disease was recorded. Special importance was given to the friction history using different scrubs, family history and photo exposure.

Results: Out of 70 patients of cutaneous amyloidosis 55 patients (78.6%) were of macular amyloidosis. Male:female ratio was 1:2.3. Majority of the patients were housewives (42.8%) and 28.5% of agriculturists. Majority of the patients (40) with cutaneous amyloidosis had disease duration between 2-5 years. In 70 patients of cutaneous amyloidosis 64.3% were symptomatic. 92% patients give history of using scrub. 50% of patients had history of photo exposure. Positive family history was seen in 7 patients (10%) and most common site involved was extensor aspect of arm.

Conclusions: From our study it can be concluded that cutaneous amyloidosis is more common among females, most patients are symptomatic, majority have history of using scrub and photo exposure and most common site involved is extensor aspect of arm.

 
Cross-sectional study of perceived stress, self-esteem, body image disturbance and suicidal ideation in patients of acne vulgaris
Authors: Ghorpade Geetanjali S. , Kadam Kranti S. , Angane Amey Y. , Unnithan Vishnu B.
Published: October 2020

Background: Acne vulgaris is characterized by chronic inflammation of the pilosebaceous units. It has been strongly associated with social impairment among adolescents. The study aims to assess the level of perceived stress, self-esteem, body image disturbance and suicidal ideation in patients of acne vulgaris; uncover any underlying association or correlation between these and the severity of acne vulgaris and further examine the association and co-relation of body image disturbance with perceived stress and self-esteem.

Methods: Cross-sectional observational study of 72 patients with acne vulgaris was undertaken by purposive sampling technique. After taking informed consent, subjects were assessed on perceived stress scale-10, Rosenberg’s self-esteem scale, appearance anxiety inventory and Columbia-suicide severity rating scale. Spearman's correlation coefficient helped to examine the correlations.

Results: 31.94% patients had severe acne, 72.22% of patients had high body image disturbance. More than half the patients of acne had high level of perceived stress. Almost three quarters of the patients had low self-esteem. 5.55% patients had suicidal ideation. No significant association was seen between severity of acne with perceived stress, self-esteem, body image disturbance and suicidal ideation. Body image disturbance was significantly associated with perceived stress and self-esteem. A positive correlation between body image disturbance and perceived stress and a negative correlation between body image disturbance and self-esteem was obtained.

Conclusions: All patients, irrespective of the objective severity of acne, can experience high perceived stress and low self-esteem along with body image disturbances. This warrants consultant liaison between dermatologists and psychiatrists in routine practice for psychosocial intervention.
Phemphigus vulgaris an autoimmune acantholysis: a case report
Authors: Ravi Abarna Lakshmi , Ravichandran Rajganesh , Sam Nikhil Cherian , Dilibatcha Jaya Shree , Balakrishnan Raveena Pachal
Published: October 2020

Pemphigus vulgaris is a rare chronic autoimmune skin disease characterized by a flaccid blister filled with clear fluid that arises on the skin or an erythematous base. The keratinocytes separated by the desmoglein present on the desmosomes which clinically manifests as fluid-filled blisters on the skin. We present pemphigus vulgaris with an unknown cause but good recovery after the management with monoclonal antibodies and corticosteroids in a 30-year-old male patient who came to the hospital with complaints of blisters on the epithelial layers of skin on the face and oral mucosa.
Clinical efficacy of Unani formulations in psoriasis (Da-us-Sadaf): a case report
Authors: Tariq Syed Shamsul Hasan
Published: October 2020

A seven-year-old male child suffering from multiple patches over the scalp with severe burning, pain, and scaly skin, came for treatment in government Unani dispensary, Majajpur, Bharatpur, Rajasthan, India. The patient has lesions and erythema with some papules over the nape of the neck. After the proper history, physical examination, positive auspitz sign, candle grease sign and grattage test he was diagnosed as a patient of scalp psoriasis. The patient was treated with Unani drugs; sharbat murakkab musaffi khoon, arq shahatra and marham safed kafoori to evaluate the efficacy of drugs and to avoid any side effects and recurrence of the disease. The patient showed excellent and admirable results within 90 days of treatment and marked remission was found in all features without any side effect, recurrence and complications.
Cost analysis study of antihypertensive agents available in India
Authors: Beck Rani Kumari , Kumar Ratan , Kumar Vibhakar , Kachhap Shweta
Published: October 2020

Hypertension is a global public health problem. To decrease its morbidity and mortality it needs lifelong treatment. There is a wide range of variation in the prices of antihypertensive drugs marketed in India. Thus, a study was planned to evaluate the difference in cost of different brands of same active drug by calculating percentage variation of cost.

The cost of different brands of commonly used antihypertensive drugs was sorted out by referring latest CIMS, MIMS and Drug Today. The cost of 10 dosage forms (Tablets/Capsules) in INR of each brand, cost Ratio and percentage Cost Variation were calculated.

Thepercentage variation in the cost was above 100% with most of single drug therapy for hypertension and is 42 out of 69. It’s found maximum in Atenolol (12.5mg) 880%, Amlodipine (5mg) 460%, Nifidipine (30mg) 456.29% and Diltiazem (90mg) 407.02%. Among the combination therapy percentage variation in the cost was above 100% in 16 out of 26. It’s found maximum in Lisinopril+Hydrochlorothiazide (5mg+12.5mg) 926%, Telmisartan+Hydrochlorothiazide (40mg+12.5mg) 254.75%, Amlodipine+Losartan (5mg+50mg) 246.96% and Amlodipine+Enalapril (5mg+5mg) 217.20%.

The average percentage price variation of the same molecules of antihypertensive drugs manufactured by different pharmaceuticals company in India is very wide. So, government, pharmaceutical company, marketing manager and prescribing doctors should think about variation of cost and do needful for providing maximum benefits to the patients receiving antihypertensive drugs.
Clinical and genetic analysis of Ser341Pro MYOC variant in a Korean family with primary open angle glaucoma
Authors:   Department of Ophthalmology, Pusan National University College of Medicine, Busan 49241, Republic of Korea, Moon Sangwoo , Kim Namhee ,   Department of Laboratory Medicine, Dong A University College of Medicine, Busan 49201, Republic of Korea, Lee Jiwoong ,   Department of Ophthalmology, Pusan National University College of Medicine, Busan 49241, Republic of Korea
Published: October 2020

AIM: To report the first discovery of Ser341Pro myocilin (MYOC) variant in Korea and analyze its clinical characteristics and genetic significance. METHODS: Ten family members from three generations participated in this study and received the thorough ophthalmologic examination. Focused exome sequencing on a proband was performed to confirm the target mutations (MYOC c.1021T>C) in the family members, and the direct sequencing was conducted. Variant was analyzed according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) guidelines. RESULTS: A nucleotide change from thymine to cytosine at c.1021T>C was found in eight family members. Three members diagnosed with primary open angle glaucoma (POAG) were characterized by severe clinical presentations, high intraocular pressure, and poor response to medical treatment (100% of the patient required filtering surgery). On variant analysis by ACMG/AMP guidelines, Ser341Pro is not found in normal population. Multiple computational predictive programs support a deleterious effect of Ser341Pro variant (PolyPhen 2, SIFT, Mutation Taster). Ser341Pro could be involved in moderate (PM) and supporting (PP) criteria (PM1, PM2, PP2, PP3). Combining the criteria, Ser341Pro has a combination of 2 moderate (PM1+PM2) and 2 supporting (PP2+PP3) criteria, which is interpreted to “likely pathogenic”. CONCLUSION: The Ser341Pro variant is correlated with severe phenotype of POAG. There are similar clinical aspects to previous studies: autosomal dominant inheritance, incomplete penetrance (62.50% and 66.67%), and proportion of patients requiring trabeculectomy (100% in both study). According to ACMG/AMP guidelines and the previous basic researches, the Ser341Pro variant had a “strong evidence of pathogenicity (PS3)” and then it could be interpreted to “pathogenic (PS3, PM1, PM2, PP2, PP3)”. Additionally, Ser341Pro variant can be reported as “c.1021T>C (p.Ser341Pro), likely pathogenic, POAG, autosomal dominant” according to guideline.
Application of Remote Sensing Technology in Geological Surveying and Mapping
Authors: Yang Wei
Published: October 2020

Remote sensing technology is widely used in various industries in China, and plays its own role. In geological surveying and mapping, its remote sensing technology can optimize the process of geological surveying and mapping, change the traditional working methods, and make its geological surveying and mapping results more accurate. Therefore, it is necessary to understand the applications of remote sensing technology in geological mapping. In this paper, we need to understand the content of remote sensing technology first, and then explain the specific application of remote sensing technology in geological surveying and mapping, explain the development prospect of remote sensing technology, and provide reference for the corresponding researchers.
Diagnostic Accuracy of MR Fistulography using Saline in the Evaluation of Perianal Fistula
Authors: Das Adithya , Prasad Visakh
Published: October 2020

BACKGROUND Magnetic resonance imaging is known to demonstrate the perianal anatomy accurately. MR Fistulography with saline as contrast agent has been described to facilitate the detection of fistula tracks. We wanted to study the diagnostic accuracy, sensitivity, specificity, positive and negative predictive values of magnetic resonance fistulography using saline as a contrast agent using surgical findings as a reference standard. METHODS Fifty-nine clinically diagnosed cases of perianal fistulae who were sent for preoperative MR imaging of the perianal fistulae were included in the study. MR imaging after instillation of saline was obtained in these patients through a cannula inserted into the external opening. T2 and STIR images in axial and coronal planes were studied. Diagnostic indices were calculated using surgical findings as reference standard. RESULTS MR imaging with saline instillation demonstrated a sensitivity of 97.92 % in the detection of primary tracks. The sensitivity in determination of internal opening, secondary tracks, abscesses and horseshoe tracks were 98.04 %, 95.24 %, 100 % and 100 % respectively. MRI had 100 % specificity in detection of primary tracks, internal opening, secondary tracks, abscesses and horseshoe tracks before and after instillation of saline. The sensitivity was found to be more in participants who did not have active perianal discharge at the time of MR examination. CONCLUSIONS MRI with instillation of saline into the fistulous track is highly accurate for the presurgical evaluation of perianal fistula with respect to accurate depiction of primary track, secondary track, abscess and horseshoe extensions. It can serve as a cheaper alternative to MR examination using I.V. Gadolinium based contrast agents or MR Fistulography using Gadolinium agents. KEYWORDS Magnetic Resonance Imaging (MRI), Perianal Fistula, Saline, Pre-Operative Assessment, Fistulography, Horseshoe, Internal Opening, Secondary Tracks
The Impact Moscow Domodedovo Airport Wastewater on Surface Water Quality
Authors: Kurbatova A.I. , Dalidenok A.D. , Mikhaylichenko K.Yu. , Savenkova E.V. , Kruglikova E.V. , Adarchenko I.A.
Published: October 2020

The impact of Moscow Domodedovo Airport wastewater on nearby surface water bodies, nameless streams which are tributaries of the Gnilusha and Muranikha rivers was investigated. Water quality was assessed by 16 indicators, the Specific Combinatorial Water Pollution Index (SCWPI) was also calculated. The quality degree of the studied reservoirs was determined.
Archaeological and Ethnographic Hobbies of F. N. Glinka in the Context of His «Active Life»
Authors:   Aliya Moldagulova School No 402, Zaytseva Natalia V.
Published: October 2020

The article is devoted to F. N. Glinka’s archaeological and ethnographic interests and research related to his interest in Russian history, his position as an educator, and his desire to be useful to society. The author focuses on Glinka’s local history journey of 1810–1811, his scientific and educational activities as Chairman of the Free society of admirers of Russian literature, folklore and ethnographic studies during the Petrozavodsk exile, archaeological research on the territory of Tver Karelia, and their poetic and scientific interpretation. Glinka’s archaeological and ethnographic research is considered in the article through the prism of his life attitudes, to which he has always remained faithful – to find happiness «in an active life, for the General benefit».
N. V. Orloff and the Beginning of Teaching of the Russian Language at King’s College London
Authors:   Alexander Solzhenitsyn Center for Russian Émigrés, Tribunskii Pavel A.
Published: October 2020

The article restores the biography of N. V. Orloff (1844–1915), a psalmist of the Church in the name of the Assumption of the Mother of God at the Russian Embassy in London, which, in addition to his official duties and translation activities, was involved in the process of establishing Russian studies in Great Britain in the late XIXth – early XXth centuries. For a quarter of a century, Orloff taught the Russian language at King’s College London, as part of the training of Oriental language specialists, who took part in the exams for official posts in the Indian Civil Service, as well as in the British army. Orloff’s resignation in 1915 symbolically coincided with the beginning of a new stage in the development of Russian studies, with the creation of the School of Slavonic Studies at King’s College London.
The Image of Austria in Russian Public Opinion in the XIX – Early XX Century
Authors:   Tambov State University, Sirotkina Evgenya V.
Published: October 2020

The article examines the process of forming the image of Austria in Russian public opinion in the 19th – early 20th century. The author pays main attention to the influence that public opinion had during this period on the development of Russian-Austrian relations. The author concludes that the negative image of Austria formed in public opinion had a significant impact on the development of the Russian government’s foreign policy, hindered the search for compromises and pushed for confrontation.
Iran and the «Arab Peace Initiative» on Syria
Authors:   Saratov State University, Baranov Alexey V.
Published: October 2020

Based on Iranian and Arabian sources, the article analyzes the formation of the «Arab peace initiative» on Syria, which was supposed to put an end to the 2011 Syrian crisis by regional states. The participation of Iran, the closest ally of Syria in the Middle East region, its reaction and the evolution of the approach to the «Arab initiative» as it is being implemented, is examined. An analysis is given of Iran’s perception of the achievements and difficulties associated with the implementation of the provisions of this «Arab initiative», and Iran’s criticism of the departure from the initial interpretation of the «initiative» by Qatar and Saudi Arabia.
«May God Save us from Living in a Fun Time...»
Authors:   State Archive of the Saratov Region, Stepanov Yuri G.
Published: October 2020

The review is dedicated to the first in our historical science biography of the historian P. G. Lybomirova. It is noted that the authors of the monograph highly professionally investigated the contribution of P. G. Lyubomirova in domestic historiography. The review analyzes the main ideas and scientific approaches of the authors of the biography.
Managerial Competencies: Factors of “Necessity and Sufficiency” in the Description and Explanation of the Phenomenon
Authors:   Institute of Psychology of Russian Academy of Sciences, Tolochek Vladimir A. , Mashkova Anna S. ,   ANVARO GROUP LLC
Published: October 2020

The study discusses results of the series of studies of competencies and features of their evaluation by managers (69 people) of different gender, age, length of employment, managerial experience, and positions, who are working in different companies. Hypotheses: 1. There are more and less relevant competencies among those that are evaluated as in-demand ones. 2. Competencies, which are evaluated as in-demand ones, are associated with evolution of managers as subjects. 3. Within the structure of managerial in-demand competencies, we can single out groups of qualities that differ in their role in the activities of subjects. Differentiated level-by-level analysis of assessments made by different groups of experts was carried out (analysis of 29 selected competencies; 19 were identified by at least 40% of experts; 8 were identified by at least 66% of experts; analysis of an expanded list of 39 competencies). Experts differed by gender, age, length of managerial work, position, career success, managerial potential, divisions within the company and type of activity (“result managers”, “process managers”). Conclusions: Evaluation of relevant (important, significant and/or preferred) managerial competencies vary depending on individual characteristics of experts (gender, age, experience, position, career success, managerial potential). 3. Lists of competencies containing the interval of 15–20 qualities can be considered optimal for solving both scientific and applied problems. The basic list of 29 competencies can be conditionally considered “sufficient and redundant”; the list of up to 19–20 competencies can be considered as “sufficient and necessary”; and the list of 8–10 “nuclear” competencies can be considered as “necessary basic” one. Managers’ evaluations of relevant competencies vary depending on professional tasks and forms of work remuneration. Unification of standard forms of remuneration for “process managers” involves the unification of their ideas about relevant competencies; differentiation of the forms of remuneration for “result managers” is associated with an increase in the variability of their ideas about the in-demand competencies of managers.
Empirical Types of Social Maturity in Young People
Authors:   Institute of Psychology of Russian Academy of Sciences, Akbarova Anastasia A.
Published: October 2020

The paper presents the results of an empirical study aimed at the identification of empirical types of social maturity in young people; its relevance is due to the lack of typology of social maturity in modern socio-psychological literature. The study was performed on a sample of young people aged 18 to 30 years old (347 people, including 178 women and 169 men). We assumed that there are various empirical types of social maturity in young people depending on the evaluation of actualized personal and social resources, the orientation of social experiences, value orientations, and behavioral activity. We used methods based on the comprehensive program developed by A. B. Kupreichenko and A. L. Zhuravlev, as well as L. M. Smirnov’s method “Basic Values and Disvalues of Russians”. The aim of this study was to distinguish the main types of social maturity from an integrative position, reflecting the view of this phenomenon as a compound, including not only socially oriented, but also individual psychological components. It is shown that the systematic approach to the study of social maturity allows us to present this phenomenon as a unified socio-psychological construct. The following components are distinguished as components of social maturity analyzed in the study: cognitive, value, emotional and conative ones. Five empirical types of social maturity were found: “ascetic”, “ambitious”, “not actualized”, “asocial”, “socially mature”. The distinguished types of social maturity are differentiated according to the grounds of the social maturity components. In the future, these types can also become the basis for creating methodological tools that diagnose parameters distinguishing subjects with different manifestation and orientation of the social maturity phenomenon.
Cuarta revolución industrial: implicaciones en la seguridad internacional
Authors: De la Peña Nicolás , Granados Oscar
Published: October 2020

Esta investigación analiza las implicaciones de la cuarta revolución industrial en la seguridad internacional. Considera los impactos en conjunto de las tecnologías como una perspectiva multidimensional de la seguridad, la perspectiva expansiva de la seguridad y la innovación disruptiva. Se encuentra que las tecnologías amplían las capacidades actuales y crean otras nuevas para los actores tradicionales y no tradicionales. Así, la seguridad internacional se expande horizontalmente dado el surgimiento de amenazas que supone el ámbito digital en las dimensiones de la seguridad, y verticalmente al transformar las capacidades de los actores del sistema internacional.