bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ROLE OF CLINICAL-HEMATOLOGICAL AND CYTOGENETIC CHARACTERISTICS IN THE PROGRAM THERAPY OF B-CELL LEUKEMIA IN CHILDREN IN THE REPUBLIC OF KAZAKHSTAN
Authors: Manzhuova L. , Tashenova G. , Tulebayeva A. , Sarsekbaev E. , Zhailaubaeva A. , Omarova G. , Yeginbergenova D.
Published: July 2023

Relevance: The study of immunological and molecular genetic characteristics of leukemia in children and the influence of biological features of the tumor population of acute B-cell lymphoblastic leukemia (B-ALL) on the effectiveness of therapy is particularly relevant for the Republic of Kazakhstan.
The study aimed to evaluate the effectiveness of modern program chemotherapy in children depending on the biological characteristics of B-cell leukemias.
Methods: The study analyzed the data of 154 children aged six months to 15 years with primary B-ALL on inpatient treatment at the Scientific Center of Pediatrics and Pediatric Surgery JSC (Almaty, the Republic of Kazakhstan) in 2016-2018. When determining events, we were guided by the criteria of the protocols of the ALL-BFM group.
Results: The age groups most exposed to B-ALL were 3-7 years old (43.5%), reflecting the so-called infant peak. In the clinical picture of this type of ALL, intoxication syndrome accompanying the period of manifestation was present in 75.3% of patients. The clinical polymorphism of the debut period determined the most diverse list of diagnoses of “masks.” Damage to organs and systems, in the form of liver failure, was detected in 41 (26.6%) children, with the development of respiratory failure in 12 (7.8%), cardiovascular failure in 5 patients (3.2%), acute kidney injury in 3 (1.9%), CNS damage in 5 (3.2%) patients. With B-ALL, the distribution of immunological variants was determined as follows: B1 – 9 (5.8%), B2 – 123 (79.8%), B3 – 18 (11,7%), B4 – 4 (2,6%) and leukemia of B-cell lymphoma was noted in one (0.6%) patient. From the group of quantitative anomalies, hyperploidy was detected in 12 (7.8%) cases. Among qualitative anomalies, t(12;21) (p13;q22) was determined in 6 (3.9%) patients and was a favorable prognostic factor (remission was recorded). Trisomy of chromosome 21 with Down syndrome in 3 (1.9%) patients with combined anomalies (isochromosome 7, trisomy 4, 6, 15, 17, translocation t(9; 22)(q34;q11) was detected in 1.3%. Translocations t(1;19)(q23;p13.3) in 5.8% and del 9-chromosome defect in 3.2% of cases.
Conclusion: The response to therapy and long-term prognosis are largely determined by biological factors such as cytogenetic features of the tumor, sensitivity to prednisone, as well as the degree of aggressiveness, which manifests itself in the form of pronounced symptoms of lymphoproliferation and hyperleukocytosis. The research has shown the high efficiency of modern ALL-BFM program therapy in children.
CERVICAL CANCER INCIDENCE AND MORTALITY IN ALMATY IN 2005-2022
Authors: Izbagambetov N. , Kaidarova D. , Bolatbekova R. , Shinbolatova A. , Valieva T. , Aidarov A. , Bagatova G. , Sarmenova A. , Zhaksylykova D. , Akkasova A. , Yestaeva A. , Satanova A.
Published: July 2023

Relevance: In Kazakhstan, the standardized incidence rate of cervical cancer for 2022 was 19 per 100,000 women, and the mortality rate was 5.9 per 100,000 female population. The overall survival of cervical cancer in the Republic of Kazakhstan for 2022 was 59.6% (95% CI: 50.7-54.2). Since 2008, in Kazakhstan, there has been a National Screening Program for cervical cancer for women from 30 to 70 years old with an interval of 4 years. Almaty is the largest city in Kazakhstan, with a high incidence and mortality from all types of cancer.
The study aimed to analyze the cervical cancer incidence and mortality in Almaty in 2005-2022.
Methods: Epidemiological analysis of cervical cancer incidence in Almaty for 2005-2022 was provided with analyzing reporting forms of documentation. Statistical processing was carried out using the SPSS v. 23.0 software.
Results: Over the past 18 years (2005 to 2022), there has been an increase in the incidence rate from 16 to 18.3 per 100,000 female population and a consistently high mortality rate, which was 6.6 per 100,000 female population in 2022. In 2005, 108 women with cervical cancer were
identified, of which 70% were patients with the first and second stages. In 2022, 198 cases of cervical cancer were registered, where the first stage
accounts for 56.5%. In recent years, there has been an increase in the frequency of registration of new cases of cervical cancer starting from 30-34
years old, with a noticeable increase up to 40-44 years old.
Conclusion: The results of this epidemiological study of cervical cancer incidence and mortality in Almaty indicate the need to improve and intensify screening among women of reproductive age, and introduce a vaccination and screening program using HPV testing.
Analysis of Unemployment and Child Trafficking in Nigeria
Authors: M. Sule , M. Ibrahim , O.A. Oladele
Published: July 2023

This study uses primary data that were obtained using a straightforward random sampling technique to analyze the analysis of unemployment and child trafficking in Nigeria. A logit model and descriptive statistics were used to analyze the data that were collected. The study's findings show that unemployment has an impact on child trafficking. The study therefore suggests that the government should increase the number of jobs available. In order to address the threat of child trafficking, the government should also analyze the efficiency of present legislation, spot any gaps, and provide fresh, effective solutions. Additionally, community-based groups should put out a lot of effort and get support in order to stop and handle child trafficking.
Isolation and Characterisation of Nateglinide and its impurity in Bulk and Marketed Formulation by HPTLC Method
Authors: Patil Pallavi M , Tekade Mayur , Agarkar Samiksha , Mohamad Taleuzzaman
Published: July 2023

The samples were applied on to the plate in the form of band with band length of 5mm. The mobile phase consisted of Chloroform: Methanol in the ratio of 8:2 v/v and 10ml of the mobile phase was used in each chromatographic run. Ascending development technique was carried out in a twin trough chamber saturated with mobile phase vapours for 15 min. The multiple wavelength detector was set at 216 nm, and quantification of the analyte was based on measuring its peak area. Rf for NTG was about 0.59. Calibration curve of NTG was linear in the range 100–600µg/band with correlation coefficient >0.9994. The drug was subjected to forced-degradation conditions of reaction, oxidization and dry heat. Unknown impurity was found in Nateglinide industrial batch stability condition at levels more than 0.1% in HPTLC analysis was characterized preliminarily by ESI-MS/MS studies. The major unknown (unknown-1 and 2) were enriched and isolated by preparative LC and structure was evidenced by 1H NMR spectroscopy, mass spectrometry and FT-IR. This technique will be used for the standard management of each drug substance and drug product. Finally, the projected method made use of hyphenated techniques as a tool for peak identity and purity confirmation.
Current and Developing In vitro and Ex vivo models for assessing medication permeability into the gut produce a Systemic effect
Authors: Fadhel Alsafar Zainab , Mohammed Sabar Al-Lami
Published: July 2023

The field of drug permeation assessment concerning the discovery and development of orally administered medications has generated a lot of attention. Inappropriate properties of some drugs such as poor water solubility, limited stability at various pH, being a substrate to efflux transporter and degradation by intestinal enzyme, resulting in inefficient oral administration. In research on improving oral absorption of drugs, the measurement of drug penetration across the intestinal membrane iscritical because it will determine oral absorption. The main question is: what is the best model for studying medication permeation and absorption? This review article answers this question by explaining many methodologies that used to evaluate oral drug permeability/absorption in drug discovery. We address the most common and unique in-vitro and ex vivo models needed to assess drug permeation, the benefits and drawbacks of each model, and the mechanisms of drug absorption that each model may analyze. Moreover, to clarify the improvement of the non-everted rat gut ex vivo technique that is acting as a promising approach in drug permeation orally.
Novel applications of Cold Atmospheric Plasma for the treatment of Plaque Psoriasis
Authors: Chandra Sharma Mukesh , Sharma Mukul
Published: July 2023

Plasma is the fourth state of matter other than solid, liquid and gases. About 99 percent of mixture of free positive negative charges, neutral particles and photons. The plasma exists in two forms: hot plasma and cold plasma. Hot plasma is used in metallurgical operations while cold plasma is used in medical, skin psoriasis treatment, food agricultural, preservation and waste water treatment. Many clinical studies prove the effectiveness of cold plasma in dermatological disease management. Recent researches have established that combined use of cold plasma and nano-formulations is helpful in delivery of poorly water-soluble drugs. Plaque psoriasis is an autoimmune disorder in which silvery, thick, dead layer of skin shades off and cause inflammation, sometimes bleeding. It occurs in 3-4 percent of total world population. Scientific studies have proved that nano-scale particles permeate easily and interact with immune cells like lnterleukin-16, cytokines and TNF-alfa during inflammation and autoimmune disorders. As a result of which, thick layer of keratinocytes is produced and formation of TNF-alfa and interleukin is inhibited which are the causes of Plaque psoriasis. Since conventional medication has only been helpful in managing it, researches have been carried out using various techniques like phototherapy, use of UVA, UVB, IPL (Intense Pulsed Light), PDL (Pulsed Dye Light), LASER and low-level LASER light etc. but their excess exposure causes risk of skin cancer. Other therapies like use of nanometric Liposomes, Niosomes and their combination therapy are some novel clinical techniques for combating symptoms but are still in clinical trial. Since, Plasma therapy is non irritating and stops the triggering mechanism of inflammation, hence the use of nanotechnological topical formulation in combination with plasma therapy has the potential to become possible treatment of Plaque Psoriasis in future.
Clinical outcome of open ankle fractures in patients above 70 years of age
Authors: Zahra Wajiha , Seifo Mina , Cool Paul , Ford David , Okoro Tosan
Published: July 2023

Shoulder pain is a common musculoskeletal complaint, and rotator cuff (RC) pathologies are one of the main causes. The RC undergoes various tendinopathic and avascular changes during the aging process. Other degenerative changes affecting its healing potential make it an appealing target for biological agents. Platelet-rich plasma (PRP) has demonstrated the potential to deliver a high concentration of several growth factors and anti-inflammatory mediators, and its clinical use is mainly supported by experiments that demonstrated its positive effect on muscle, ligaments, and tendinous cells. This review aimed to specify the role of PRP and its future applications in RC tendinopathies based on the current clinical evidence. Due to the different characteristics and conflicting outcomes, clinicians should use PRP with moderate expectations until more consistent evidence is available. However, it is reasonable to consider PRP in patients with contraindications to corticosteroid injections or those with risk factors for inadequate healing. Its autologous origin makes it a safe treatment, and its characteristics make it a promising option for treating RC tendinopathy, but the efficacy has yet to be established.
Biorreator osmótico anaeróbio acoplado à destilação com membranas como alternativa
para a concentração e recuperação de nutrientes no tratamento de esgotos domésticos
Authors: Arcanjo Gemima Santos , Santos Carolina Rodrigues dos , Cavalcante Bárbara Fernandes , Moura Gabriela de Alcântara , Ricci Bárbara Caroline , Mounteer Ann Honor , Amaral Míriam Cristina Santos
Published: July 2023

O objetivo deste trabalho foi estimar a precipitação de sais de fósforo em biorreator osmótico anaeróbio acoplado à destilação com membranas (AnOMBR-MD) empregado no tratamento de esgoto doméstico. MgCl2 foi utilizado para compor a solução osmótica (SO) do AnOMBR-MD. Um módulo híbrido com membranas de osmose direta (OD) e destilação (MD) foi submerso em um biorreator, e os fluxos de permeado estabilizaramse em 0,5 L m-2 h-1. A rejeição do sal pela MD foi superior a 99,6%, e mais de 90% do carbono orgânico dissolvido foi removido. Uma fração do N-NH4 + permeou a membrana de OD, e a SO apresentou concentração média de 7 mg L-1. P-PO4 3- não foi detectado na SO nem no destilado, com remoção global maior que 99,99% durante toda a operação, entretanto a concentração de P-PO4 3- no líquido reacional (LR) foi menor que a calculada pelo balanço de massa, indicando precipitação de sais com o íon. Foi utilizado o software Visual MINTEQ 3.1 para calcular as especiações dos íons inorgânicos (Ca2+, Mg2+, NH4 + e PO4 3-) e a precipitação espontânea de P-PO4 3-. Com o aumento da concentração de Mg2+ no LR, o modelo termodinâmico mostrou que pode ter havido precipitação de MgCO3 , CaHPO4 e MgNH4 PO4 .6H2 O, o que também justifica a redução das concentrações de N-NH4 + e P-PO4 3- no LR no 16º dia de operação. Os sais precipitados podem ser utilizados como fertilizante agrícola, o que mostra a sustentabilidade do processo de tratamento de esgotos em AnOMBRMD, promovendo a integração do nexo água-alimento.
ПОСТРОЕНИЕ ВСЕНАПРАВЛЕННОЙ АНТЕННЫ НА КРУГЛОМ ВОЛНОВОДЕ С ПРОСТЫМ ВОЗБУДИТЕЛЕМ РАБОЧЕЙ МОДЫ
Authors: НЕРСИСЯН А.С. , ДАВТЯН Р.А. , АГАРОНЯН А.К. , АВЕТИСЯН В.Г.
Published: July 2023

Предлагается использование круглого волновода с аксиально симметричной модой E_01. Такой вертикально установленный волновод содержит на разных высот¬ных ярусах поперечные излучающие щели. Созданной таким образом антенне возможно придать свойство всенаправленности в азимутальной плоскости, что важно для систем подвижной связи. На основе масштабного моделирования представлены расчет и конструирование дешевого в изготовлении и надежного в работе возбудителя моды .
Análisis constructivo y de presupuesto de losas alivianadas de una dirección vs losas construidas en dos direcciones: estudio de caso en Cuenca y Azogues
Authors:   Universidad Católica de Cuenca, Molina Ponce Jonnathan Jesús , Raiban Calle Claudio Fabricio ,   Universidad Católica de Cuenca, Nieto-Cárdenas Jaime Xavier ,   Universidad Católica de Cuenca
Published: July 2023

El artículo trata sobre losas alivianadas en una y dos direcciones utilizando sistemas de viguetas, bloques de poliestireno expandido y bloques de pómez, se analizan dos estructuras construidas, una en Cuenca y otra en Azogues. Entre estas estructuras existen diferencias, las más destacables son las metodologías de construcción y la evolución de los materiales debido a las épocas en que se construyeron. Se discute resultados de diseño de las losas alivianadas según la normativa ACI (American Concrete Institute) y se muestran técnicas de construcción de estas losas en nuestro medio. Se indican ventajas estructurales y económicas de estas losas alivianadas analizadas frente a las construidas. Se observó que las losas alivianadas poseen una capacidad a cortante reducida debido a la reducción de área por el alivianamiento colocado. Las zonas más críticas del diseño se producen en los momentos negativos ubicados en los extremos continuos del pórtico. Finalmente, se realizó una comparación entre las estructuras puestas en obra y las losas analizadas teóricamente, los resultados muestran que las losas alivianadas analizadas ofrecen mayores beneficios estructurales y económicos frente a los puestos en obra cumpliendo con las resistencias de diseño.
Rezension von: Matz, Klaus-Jürgen, Kleine Geschichte des Landes Baden-Württemberg
Authors: Wettengel Michael , Matz Klaus-Jürgen
Published: July 2023

Klaus-Jürgen Matz: Kleine Geschichte des Landes Baden-Württemberg (Regionalgeschichte – fundiert und kompakt). Leinfelden-Echterdingen: DRW-Verlag 2010; 216 S., 25 Abb., 6 Tab., geb., 19,90 EUR
Rezension von: Lang, Stefan, Ausgrenzung und Koexistenz
Authors: Ullmann Sabine , Lang Stefan
Published: July 2023

Stefan Lang: Ausgrenzung und Koexistenz. Judenpolitik und jüdisches Leben in Württemberg und im „Land zu Schwaben“ 1492-1650 (Schriften zur südwestdeutschen Landesgeschichte 63). Ostfildern: Jan Thorbecke Verlag 2008; 432 S., zahl. Abb., geb., 46,00 EUR
Rezension von: von Pflaumern, Johann Heinrich, Ein Romführer von 1650
Authors: Sprenger Kai-Michael , Pflaumern Johann Heinrich von
Published: July 2023

Johann Heinrich von Pflaumern: Ein Romführer von 1650. Das Romkapitel seines „Mercurius Italicus“. Herausgegeben, übersetzt und kommentiert von Dietrich Winkelmann (Bibliotheca Suevica, 30). Konstanz / Eggingen 2010; Edition Isele, 539 S., Abb., 25,00 EUR
Cómo sería un mundo sin universidades
Authors: González Díaz José Rafael
Published: July 2023

The conviction that the university is unnecessary and can be replaced by devices perfectly aligned with the interests of the company is growing in some sectors. The experts who announce the death of the university are multiplying. It is worth reflecting on the characteristics that this world without universities would have and highlight the need for a space free of political and economic conditioning.
PERITONEAL DIALYSIS-ASSOCIATED PERITONITIS : A SYSTEMATIC REVIEW
Authors: Nur Amelia Devita
Published: July 2023

Background: Peritoneal dialysis is infectious and non-infectious. Peritoneal dialysis causes catheter exit, tube tunnel, and peritonitis. Noninfectious consequences of peritoneal dialysis include catheter malfunction, external leakage, abdominal wall anomalies, scrotal edoema, pleural-peritoneal fistulas, failed ultrafiltration, and encapsulated sclerosis. PD complications include peritonitis. The International Society for Peritoneal Dialysis (ISPD) offers specific recommendations on PD-associated peritonitis prevention and treatment, however clinical practise differs greatly amongst dialysis units. Aim: This article examines the link between peritoneal dialysis and peritonitis and presents its findings. Methods: By evaluating the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 standards, this study demonstrated that it met all of the requirements. This enabled the researchers to ensure that the study was as up to date as feasible. Publications published between 2000 and 2023 were included in the search strategy, which included a variety of electronic reference databases (including Pubmed and SagePub). We did not consider review papers, duplicate publications, or half completed articles. Result: In the PubMed database, the results of our search brought up 133 articles, whereas the results of our search on SagePub brought up 69 articles. The results of the search conducted for the last year of 2000 yielded a total of 20 articles for PubMed and 8 articles for SagePub. In the end, we compiled a total of 21 papers, six of which came from PubMed and three of which came from SagePub. We included nine research that met the criteria. Conclusion: Gram-positive bacteria are the most common cause of Parkinson's disease-associated peritonitis. Despite the high frequency of PD-associated peritonitis, it has a high cure rate.
Did Christ die only for the Elect?: Limited Atonement vs. Unlimited Atonement
Authors: Boaheng Isaac
Published: July 2023

Almost all Christians believe that the satisfaction rendered by the death of Christ was in itself enough for the salvation of humanity. Yet, there is no consensus among Christians on the question of the beneficiaries of Christ’s atoning sacrifice. The question of whether Christ’s suffering and death benefited all humanity or only an elected few has triggered much debate among Christian scholars. The different responses to the question of the extent of the atonement can be categorized broadly into two, namely; particular atonement (that is, the view that Jesus Christ died only for the elect) and universal atonement (that is, the idea that Christ died for all persons). The significance of the debate and the rise in interest in this subject in recent times has prompted this literature-based research which critically reviews and analyzes publications (including books, journal articles, and dissertations) on the extent of Christ’s atonement to see how one might make meaning of the ongoing debate. The paper first presents a survey of the evidence adduced for both views; it then considers Calvin’s view on the subject and ends with the author’s position that the atonement is unlimited in scope in that the offer of salvation is for all people; yet it is limited in effect because only those who believe in Jesus are truly saved.
Difficulties in purchasing and contracting in support of research projects in public institutions in Brazil: Challenges of Control or dysfunction in the relationship between the involved agents?
Authors: Silva Eduardo , Barbosa Josiane , Murari Thiago
Published: July 2023

This article proposes a new perspective on the difficulties in purchasing and contracting in support of research projects in public institutions in Brazil, which persist even after the legal innovations introduced by the New Legal Framework for Science, Technology, and Innovation (Law 13.243/2016), which were intended to simplify and streamline the procurement processes of goods, services, and supplies for the smooth progress of scientific research. The literature's approach to the subject tends to place greater emphasis on the dysfunctions of Control and issues related to the culture of public administration. However, in this article, we propose expanding this perspective to the intricate relationship between the agents involved or interfering in the process and the complexity of this system, with various problems that may be reinforcing and unintentionally contributing to resistance to the intended change by the new legal framework.
Repertoire of social skills of teachers in a full-time public school
Authors: Oliveira Adriane Lima da Silva , Lellis Irani Lauer , Tavares Edilene Ferreira Machado , Magalhães Jayce Lana Mota , Oliveira Maiara Silva
Published: July 2023

This article aimed to investigate the social skills repertoire of elementary school teachers from a full-time school in the urban area. The research was characterized as bibliographical and field, exploratory, descriptive, with a qualitative approach. The Social Skills Inventory – 2 (IHS-2) was used. Data were collected on the respective instrument's web platform. As for the teachers' repertoire of social skills, it was found that most had a good repertoire of social skills, with results within the average for most items. On the other hand, 3 of the participants presented as a result an inferior repertoire of social skills.
Concretes prepared with recycled aggregate and metakaolin: aspects of mechanical resistance and electrical resistivity
Authors: Teixeira Eduardo da Cruz , Santos Emerson Renildo Silva , Medeiros Camila Macêdo , Barbosa Normando Perazzo , Ferreira Thássia Isis Barbosa
Published: July 2023

Waste recycling is shown as an efficient alternative to minimize the impacts caused, such as the recovery of construction and demolition waste (CDW), but the properties should be studied and analyzed for their better use in concretes. In addition to environmental concern in the aggregate of concrete, another factor is the emission of CO2. Several studies are being done to replace part of the cement mass with other concrete components. Among these additions, it is possible to emphasize as the most used, in Brazil, the metakaolin. Studies show that concretes prepared with CDW generally tend to have a higher permeability, lower mechanical strength and difficulty in workability, and metakaolin as an additive that enhances the cementitious composite, compensating for the possible technical disadvantages of CDW as an aggregate. This work has as objective the macrostructural and microstructural analysis of concretes prepared with metakaolin and recycled aggregate CDW. A reference concrete, class 30, with consumption of 442 kg / m³, and families using CDW source aggregate with 25% and 50% substitution percentage and metakaolin in place of cement in 5 and 10% was prepared. The results show optimized behavior of the concretes prepared with metakaolin and CDW aggregate.
Аналіз загроз національній безпеці у сфері внутрішньої політики (експертне опитування)
Authors:   Національний інститут стратегічних досліджень, Павленко І. , Нагірний В. ,   Національний інститут стратегічних досліджень, Потапенко В. ,   Національний інститут стратегічних досліджень, Маляревський Є. ,   Національний інститут стратегічних досліджень
Published: July 2023

Аналітична доповідь містить результати експертного опитування, що провів у квітні – травні 2023 р. центр внутрішньополітичних досліджень НІСД в межах реалізації дослідницького проєкту «Аналіз загроз національній безпеці у сфері внутрішньої політики». В опитуванні взяли участь працівники центру та близько 50 зовнішніх експертів – представники дослідницьких, освітніх та громадських організацій, науковці з різних регіонів України. Головне завдання проєкту – визначення «точок вразливості» українського суспільства та системи управління, оцінка ризиків їх використання РФ з метою дестабілізації ситуації у країні. Мета – запропонувати рішення, спрямовані на упередження розвитку кризових ситуацій в Україні.
LIQUIDITY DETERMINANTS OF SHARIA COMMERCIAL BANKS IN INDONESIA
Authors: Syafina Laylan
Published: July 2023

This research aims to determine whether the Capital Adequacy Ratio (CAR), Return on Assets (ROA), Return On Equity (ROE) and Firm Size partially and simultaneously affect liquidity as stated by the Financing to Deposit Ratio (FDR). This type of research is quantitative with a descriptive approach. The data analysis technique used SPSS 22 software. The tests in this study were the classical assumption test, multiple regression analysis, and hypothesis testing. The results showed that partially the Capital Adequacy Ratio (CAR), Return on Assets (ROA), and Return On Equity (ROE) had no effect on the Financing to Deposit ratio (FDR) while Firm Size partially had a negative and significant effect on Financing. to Deposit ratio (FDR). Simultaneously, Capital Adequacy Ratio (CAR), Return on Assets (ROA), Return On Equity (ROE), and Firm Size have a joint and significant influence on the Financing to Deposit ratio (FDR).
IMPLEMENTATION OF E-LEARNING WITH SIPADI POLMED-BASED FLIPPED CLASSROOM MODEL IN BASIC JAPANESE LANGUAGE COURSES
Authors: Hasibuan Annalisa Sonaria
Published: July 2023

This study titled Flipped Classroom Implementation in Japanese Language Teaching in Business Administration Study Program aims to help students in understanding Japanese language courses as additional foreign languages that must be studied for two semesters. Flipped Classroom is one of the teaching methods where students get learning materials along with exercises and assignments (individuals or groups) in the form of videos and access them online through Sipadi, to be done outside the classroom to then be discussed during the course hours. Therefore, in class the teacher is reviewing materials, discussing assignments or exercises, and answering questions of students who still do not understand about the materials provided. While students at the time of the learning is expected to have gained an understanding of the material delivered. This method is tried to overcome the time constraints given for this course, which is only once a week for three hours of lectures. In addition, the condition of learning during the pandemic requires kbm to be done online, so that with this method students are not saturated, can be more active and also independent in accessing materials, learning can be carried out not limited by space and time. It is expected that with the implementation of this method, students' involvement in teaching and learning activities in the classroom increases and can easily understand the materials delivered.
THE ROLE OF EMPLOYEE ACHIEVEMENT: WORK ABILITY AND MOTIVATION
Authors: Tupti Zulaspan , Lestari Dinda
Published: July 2023

The purpose of the study was to determine the effect of ability and motivation on employee performance at PT. Kimia Farma (Persero) Tbk Medan Red Cross Branch. The sample in this study were 40 respondents who were employees of PT. Kimia Farma (Persero) Tbk Medan Red Cross Branch. The results of this study were collected through a questionnaire which was processed and analyzed using Multiple Regression. The sampling method in this study used the saturated sampling method. The data quality test used is a validity test using Corrected Item Total and a reliability test using Cronbach Alpha. To test the hypothesis in this study. The data analysis technique in this study is the classical assumption test, multiple linear regression test, hypothesis testing consisting of t test, and F test and perform a determination test. That there is a positive effect of the ability variable on the employee's work performance variable, there is a positive influence of the motivational variable on the employee's work performance variable for ability and motivation to have a significant influence on the work performance of PT Kimia Farma (Persero) Tbk Medan Red Cross Branch.
IMPROVING CRITICAL THINKINGABILITY THROUGH GUIDED DISCOVERY METHODS ASSISTED BY CABRI 3D SOFTWARE
Authors: Batubara Ismail Hanif , Sari Indah Purnama
Published: July 2023

This research proves that the use of knowledge of software programs such as Cabri 3D improves college students' Critical Thinking competencies compared to those with the software program's help. This evidence is accomplished to reach the development of college students' numerical thinking capacities instructed to use guided disclosure gaining knowledge of strategies assisted with the aid of using Cabri 3D with the guided discovery gaining knowledge of approach without a Computer program. This lesson experimental research takes a look at a populace of 122 people. Randomly instructions are decided on from the to be had guides divided into pattern instructions. The first experimental magnificence changed into given remedy with the aid of using Guided Discovery gaining knowledge of Method assisted with the support of using an Cabri 3D software program, at the same time as some other degree changed into given remedy with the aid of using guided discovery gaining knowledge of approach without Cabri 3D software program. The tool used on this take a look at changed into a check. Then the check effects are examined through the use of the t-check with the assist of SPSS. The check standards are rejected H0 if the table of t is smaller than the t count. Effects confirmed rely on changed into 2,785 simultaneously as the t desk changed into 2,000. The college students taught with the aid of using the guided discovery gaining knowledge of approach assisted with using Cabri 3D (First experiment) are better than without software.
SENSITIVITY OF OBTAINING ERRORS IN THE COMBINATION OF FUZZY AND NEURAL NETWORKS FOR CONDUCTING STUDENT ASSESSMENT ON E-LEARNING
Authors: Sari Indah Purnama , Batubara Ismail Hanif , Al-khowarizmi Al-Khowarizmi
Published: July 2023

Utilization of information technology in the midst of the covid-19 pandemic, including in the field of education, namely by holding On-line Classes. The development of information technology is also growing rapidly, especially in the field of education. Distance learning facilities via the Internet allows maha students undertake independent learning so as to facilitate the learning process. In addition, with the development of the system, it is hoped that this facility will be able to direct the ongoing learning process, so that the learning process that occurs resembles the learning process in the classroom. In conducting an assessment, a lecturer/teacher must pay attention to the rules of assessment. However, because there are no clear rules in conducting the assessment, the assessment process must be designed adaptively to adjust its calculations to the assessment rules of the lecturers / instructors who use the system. In this study, the fuzzy logic method approach and the artificial neural network method were used in calculating the assessment of learning outcomes.
JOB OPPORTUNITIES FOR FRESH GRADUATES BASED ON INDUSTRY PARTNERSHIP MODEL IN NORTH SUMATRA PROVINCE
Authors: Yusuf Muhammad , Nugrahadi Eko Wahyu , Tambunan Khairuddin Ependi , Harefa Kornelius
Published: July 2023

This study aims to examine the partnership model of the Industrial World to Expand Em-ployment Opportunities for Higher Education Graduates in Sumatra Province by examin-ing the variables of graduate quality, internship experience and skills on job op-portunities. This research was conducted in Medan, North Sumatra with the sample of this research being graduates of economics degree from PTN and PTS in Medan City. There were 156 respondents who graduated at the end of December 2020 in ten economic facul-ties. The results of the study based on multiple regression test showed that all variables had a significant effect on job opportunities. This proves that internship experience is im-portant for students because it affects their competitiveness to get a job after graduating from college. The limitation of this research is that the number of samples is too small so that the generalizability is very small. The recommendation of this research for the next study is to increase the number of samples and a wider research area
STRENGTHENING THE HALAL INDUSTRY BASED ON MICRO, SMALL AND MEDIUM ENTERPRISES FOR FOOD PRODUCERS CERTIFIED BY THE INDONESIAN ULAMA COUNCIL IN NORTH SUMATRA PROVINCE
Authors: Nugrahadi Eko Wahyu , Puddin Khafi , Armayanti Nelly , AW Jumiadi
Published: July 2023

This study aims to determine the development of the halal industry for SMEs in North Sumatra Province. The test is carried out by factor analysis, namely to find out various factors that can strengthen the development of the halal industry. The factors in question are the role of the government, awareness of MSME actors, sharia compliance. Based on the results of the analysis, all factors determine the strengthening of the halal industry with a significant loading factor. The sample in this study were 45 SMEs spread across the cities of Medan, Binjai and Deli Serdang. The sampling technique used purposive sampling method with criteria for business age above 5 years, average monthly sales above 50 million and already having MUI halal certification. The contribution of this research shows that micro, small and medium enterprises to the regional economy. Local governments play a role in the development of the halal industry. The limitation of this study is that it does not include regulatory variables so that local governments need to issue regional regulations that regulate business/industry actors to always maintain the quality of their products according to Islamic law which is marked by certification from Indonesian Ulama. Board. Further research can add other relevant variables
CSR MANAGEMENT BASED TRIPLE HELIX MODEL IN NORTH SUMATRA PROVINCE
Authors: Kholis Azizul , Nasirwan Nasirwan , Lubis Sulaiman , Anggriyani Anggriyani
Published: July 2023

This study aims to examine CSR management based on the triple helix model in compa-nies in North Sumatra Province. The research was conducted from May to July 2021 by distributing questionnaires to 112 companies operating in North Sumatra Province, 20 uni-versities and 33 district/city governments. The test is based on the triple helix model, namely the involvement of universities, companies and local governments in managing CSR so that it is more well implemented and integrated. The sampling technique for com-panies is random sampling spread over 5 major cities, namely, Medan, Pematang Siantar, Tebing Tinggi, Padangsidimpuan, and Sibolga. The results of hypothesis testing indicate that there is no difference in the perceptions of the three parties for the integration of CSR management. The test results also prove that the commitment of the three elements of the triple helix supports each other for integrated CSR management in North Sumatra Prov-ince. The limitation of this research is that there are different sampling techniques for each element of the triple helix so that sample bias is predicted. The recommendation of this re-search for further studies is to add mass media as an element to support integrated CSR management.
Effect Of Return On Asset And Debt To Equity Ratio To Tax Avoidance In Company
Authors: Dahrani Dahrani
Published: July 2023

The debt equity ratio shows the t-count statistical test value of 0.405, which is smaller than the t-table of 2.032, while the sig value of 0.688 is greater than 0.050, this indicates that the debt equity ratio has no effect on tax avoidance. The results of the research on return on assets and debt equity ratio together show the calculated F statistic value of 5.143 which is greater than the F table value of 3.280 while the sig value of 0.011 is smaller than 0.05, this indicates a significant influence between return on assets and debt equity ratio to tax avoidance simultaneously. This shows that return on assets has a positive and significant effect on tax avoidance. The debt equity ratio shows the t-count statistical test value of 0.405, which is smaller than the t-table of 2.032, while the sig value of 0.688 is greater than 0.050, this indicates that the debt equity ratio has no effect on tax avoidance. The results of the research on return on assets and debt equity ratio together show the calculated F statistic value of 5.143 which is greater than the F table value of 3.280 while the sig value of 0.011 is smaller than 0.05, this indicates a significant influence between return on assets and debt equity ratio to tax avoidance simultaneously. This shows that return on assets has a positive and significant effect on tax avoidance. The debt equity ratio shows the t-count statistical test value of 0.405, which is smaller than the t-table of 2.032, while the sig value of 0.688 is greater than 0.050, this indicates that the debt equity ratio has no effect on tax avoidance. The results of the research on return on assets and debt equity ratio together show the calculated F statistic value of 5.143 which is greater than the F table value of 3.280 while the sig value of 0.011 is smaller than 0.05, this indicates a significant influence between return on assets and debt equity ratio to tax avoidance simultaneously. 405 is smaller than t table of 2.032 while the sig value of 0.688 is greater than 0.050, this shows that the debt equity ratio has no effect on tax avoidance. The results of the research on return on assets and debt equity ratio together show the calculated F statistic value of 5.143 which is greater than the F table value of 3.280 while the sig value of.
SKILLS BASED COMPETENCY AND COMPETITIVENESS OF ACCOUNTING PRACTITIONERS IN ASEAN EMERGING MARKET
Authors: Pane Sanusi Gazali , Siregar Saparuddin
Published: July 2023

Competency frameworks are urgently needed by accounting practitioners within organizations to carry out their roles effectively. Moreover, in the context of economic integration and labor mobility between regional countries, the role of accounting practitioners becomes one of the eight professions affected by professional competition. The purpose of this research is to measure the level of competence of accounting practitioners using competency assessment methods that refer to technical and non-technical assessments through the collection of relevant evidence on accounting work. The results of this study showed that during the testing period of 2018-2020 as many as 83.01 failed to meet the level of competence. While 16.01 percent have competency standards in the qualification of accounting technicians and professional clusters. The implications of these findings illustrate that the difficulty of labor market accessibility in the domestic and regional arena will increase and the resulting competitiveness will be lower.  Improvisation is controlled and relevant to, especially in the world of education by directing a paradigm-based curriculum competency framework. This concept is at least in line with the government's commitment to create superior human resources for Indonesia to grow and be more advanced.
ANALYSIS OF COMMERCIAL CUSTOMER SATISFACTION LEVEL IN PT PERUSAHAAN GAS NEGARA (PERSERO) TBK SBU DISTRIBUSI WILAYAH III SUMATERA BAGIAN UTARA
Authors: Ario Firman
Published: July 2023

This study examined of Commercial Customer Satisfaction Level In PT Perussahaan Gas Negara (Persero) Tbk, SBU Distribusi Wilayah III Sumatera Bagian Utara. . The study used descriptive statistical analysis using cartesian diagram which divided into four parts bounded by two lines that intersect perpendicularly at points X and Y. This diagram is also called the importance-performance matrix is used to describe the priority dimension of service quality. or service attributes that need to be improved and serve as a guide for formulating improvement strategies based on decrease in the number of customers in the commercial customer segment from 579 customers in 2012 to 540 customers in 2017, while customers in other segments, namely industry and households increased. The population in this study is all commercial customers in the State Gas Company (Persero) Tbk SBU Distribusi Region III in Medan City as many as 540 commercial customers during the period of 2018. Sampling technique in this study by using probability sampling method with simple random sampling technique. From the results of the research and discussion described in the previous chapter, it is concluded that based on the Descriptive Analysis and Cartesian Diagram Analysis that the influence of service quality consists of: tangible (direct evidence), reliability (reliability), responsiveness (responsiveness), assurance (guarantee). ), and empathy for the level of satisfaction of commercial customers at PT. Perusahaan Gas Negara (Persero) SBU Distribusi Wilayah III Sumatera Bagian Utara is categorized as sufficient. From the five dimensions of service quality, the most dominant variable inservice improvement is the tangible variable (direct evidence).
LITERATURE STUDY OF THE DYNAMICS OF INDONESIAN HALAL CERTIFICATION
Authors: Hiya Nirmadarningsih , Nawawi Zuhrinal M.
Published: July 2023

This study examines research related to “Halal Certification” in national journal articles. Using descriptive statistical analysis and narrative review of 18 publication articles related to "Halal Certification". All articles used as samples have been published. The results show that research related to Halal Certification discusses more about the regulation of the application of halal certification as many as 6 articles (33%), then discusses how the halal certification process as much as 5 articles (28%) followed by a discussion of the impact of halal certification on the economy and socialization of each 4 and 3 articles respectively. The research approach used in the article under study as a whole uses a qualitative approach.
Post infectious granuloma masquerading intradural extramedullary spinal tumor
Authors: Khattak Shahid Nawaz , Rehman Sarah , Younis Maria , Waleed Waleed , Tariq Muhammad Usman , Aman Raza
Published: July 2023

Background: There are several non-neoplastic lesions which mimic intradural extramedullary spinal cord neoplasm in their radiographic and clinical presentation. Intradural extramedullary granulomas are granulomas that form within the dura mater, which is the outermost protective layer surrounding the spinal cord. Variety of infections, such as Tuberculosis or Fungal infections (histoplasmosis and coccidioidomycosis), and inflammatory conditions, such as sarcoidosis, can cause granulomas to form within the dura mater. Case description: The authors report a very rare case of intradural extramedullary non-specific inflammatory lesion of unknown origin, with no signs of infection at present. However, the patient had a history of fever and backache 3 months back for which he was treated at periphery. He has recovered from fever but backache has gradually worsened. Conclusions: Intradural extramedullary lesions that mimic a tumor can be various and difficult to interpret. Preoperative MRI does not allow a certain diagnosis because these lesions have a very similar signal intensity pattern. Specific tests for infective pathologies are useful for diagnosis, but histological examination is essential for establishing a certain diagnosis.
Intoxicación por plaguicidas en autopsias medicolegales. Tegucigalpa 2014-2020
Authors: Matamoros Mireya , Castro Oscar , Sabillón Nicolas
Published: July 2023

Justificación: Los plaguicidas han provocado un significativo problema de salud pública ya que han generado una importante carga a la mortalidad y a la morbilidad. Los suicidios con plaguicidas representan alrededor de un tercio de todos los suicidios en el mundo. Objetivo: Caracterizar las muertes relacionadas a plaguicidas, sometidas a autopsia médico legal en la Dirección de Medicina Forense de Tegucigalpa durante los años 2014-2020. Metodología: Se consultó la base de datos digital la Dirección de Medicina Forense, encontrando 255 casos relacionados a muerte por plaguicidas de los que se seleccionaron 215 casos con expediente completo y disponible. Los cálculos estadísticos se realizaron con el programa PSPP. Resultados: Se encontraron 215 casos, el 58% eran hombres y el 42% mujeres, 54% eran solteros y 29% en unión libre. Sin escolaridad 11%, primaria incompleta 20%, primaria completa 15%, secundaria incompleta 12%, secundaria completa 10%. Respecto a la ocupación de los fallecidos, los oficios domésticos fue la más frecuente entre las mujeres y la agricultura entre los hombres. El 65% eran personas jóvenes menores de 40 años con una media de edad de 35 años (rango 8-89a). La manera de muerte más frecuente fue suicida con el 71%. El plaguicida más utilizado como instrumento de muerte fue el fosfuro de aluminio (66%). Conclusión: La mayoría de las muertes por intoxicación con plaguicidas fueron suicidas; hombres jóvenes, menores de 40 años, solteros, con escolaridad que no sobrepasaba la secundaria; utilizaron las pastillas de fosfuro de aluminio como instrumento de autolesión. Se requiere estudiar más detalladamente el uso de tóxicos en general y de los plaguicidas en particular como instrumentos de autolesión y se evidencia la necesidad imperiosa de habilitar medidas de regulación para la comercialización y campañas de educación en la población para el uso y manejo adecuado.
مشكالت تعلّم النحو العريب لدى طلبة أكادميية الدراسات اإلسالمية والعربية، جامعة األمرية انراديواس بتايالند
Authors: Chaka Lookman
Published: July 2023

يهدف هذا البحث إىل تشخيص املشكالت يف تعلّم النحو العريب لدى طلبة أكادميية الدراساتاإلسالمية والعربية يف جامعة األمرية انراديواس بتايالند،كما يهدف إىل تذليل املشكالت يف تعلّمالنحو العريب واقرتاح احللول، وابإلضافة إىل ذلك فالبحث يعمل على تنمية وعي الطلبة حنو أمهيةJurnal Pengajian Islam, 2023, Bilangan 16, Isu I, Halaman 101-128 102تعلم النحو العريب وتعزيز كفائتهم اللغوية، نظرا إىل مادة النحو العريب يف أكادميية الدراساتاإلسالمية والعربية جبامعة األمرية انراديواس هي مساقا إجباراي لدى املتعلمني يف كل أقسام الدراسيأن يتعلموه. اتبع الباحث املنهج الوصفي التحليلي يف مجع املعلوم ات والبياانت وحتليلها، واستخدماالستبانة كأداة جلمع البياانت، ومت توزيعها على عينة البحث من )97( طالبا وطالبة، وقد توصلالبحث إىل العديد من النتائج ومن أمهها: ) 1( تواجه الطلبة عديدة من املشكالت يف تعلّم النحوالعريب، أكثرها املشكلة اليت تتعلق بطريقة التعليم، ومن أسباهبا عدم تنويع لدى املعلمني يف استخدامالطريقة التعليمية اجلديدة يف التعليم. )2( اختار املعلمون طرق التعليم املناسبة أمر ضروري، تساعدعلى إصالح جو التعليم وتيسريه، و يرى الباحث الطريقة التواصلية من أهم وأجنح الطر ق التعليميةاجلديدة، ألن ا تسعى إىل متكني املهارات اللغوية ال سيما املهارات التواصلية.