bluuebunny/crossref_metadata_2025 huggingface dataset:
Prospective, multi-site evaluation of the Cepheid Xpert Xpress CoV-2
plus
test on nasal and nasopharyngeal swabs
Authors: Greninger Alexander L. , Larcena Allan , Patel Amrish , Webster Brian , Ulen Christina , Green Dallas F. , King Dana , Patel Deepesh Rubin , McElvania Erin , Harnett Glenn , Jandali Imad , Gibson Jane , Killion Jennifer , Atwi Jibran , Bergmann Kelly , Slade Lance , Allen Staat Mary , Faron Matthew , Washington Megan , Patel Rahul , Annamalai Rajasekaran , Ackerman Ronald , Stewart William P. , Amador Yuliet Mora , Rao Deepa , Liu Xiaohong , Raman Aarthi
Published: November 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues its largely aseasonal spread with millions of cases per year. Highly sensitive, point-of-care testing is critical for rapid detection of coronavirus disease 2019 (COVID-19) cases and initiation of antiviral therapy to avert adverse health outcomes and reduce onward transmission of the virus. While hundreds of COVID-19 diagnostics received emergency use authorization from the FDA during the pandemic, significantly fewer have navigated the course to FDA clearance or approval. Here, we determined the clinical performance of the Cepheid Xpert Xpress CoV-2
plus
for detection of SARS-CoV-2 in 3,750 anterior nasal swab (NS) specimens and nasopharyngeal swab (NPS) from 32 sites in comparison to the FDA-authorized BioFire Respiratory Panel 2.1. Three-quarters of specimens collected were tested on the Xpert Xpress CoV-2
plus
in the point-of-care setting. Overall positive percent agreement (PPA) was 98.1% (95% CI: 96.7%–98.9%) and negative percent agreement (NPA) was 98.3% (97.7%–98.7%). Performance of the Xpert Xpress CoV-2
plus
was slightly improved in NS compared to NPS specimens, with PPA of 99.3% versus 97.0% (Fisher’s exact test,
P
= 0.06) and NPA of 98.3% versus 98.2% (
P
= 0.89), respectively. Assay PPA was similar between untrained and trained users (98.7% vs 97.3%,
P
= 0.75), while NPA was slightly improved for untrained users (99.0% vs 97.6%,
P
= 0.0003). This study showed that Cepheid Xpert Xpress COV-2
plus
is highly sensitive and specific/has high PPA and NPA for detection of SARS-CoV-2 from both NS and NPS specimens.

IMPORTANCE

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause millions of infections and tens of thousands of deaths per year in the United States. While the FDA authorized hundreds of SARS-CoV-2 tests during the public health emergency, significantly fewer have made the transition to being cleared or approved. There continues to be a need for FDA-authorized point-of-care SARS-CoV-2 testing that can be performed by untrained users. We conducted a large prospective study of the Cepheid Xpert Xpress CoV-2
plus
test for detection of SARS-CoV-2 in both nasal and nasopharyngeal swabs by trained and untrained users. The assay demonstrated excellent clinical performance characteristics and, as a result of this study, was cleared by the FDA.
Ring width distribution as a valuable anatomical trait for predicting bending strength and rigidity in European oak wood beams
Authors: Muñoz Guillermo Riesco
Published: November 2024

Ring width variability affects the elasticity and strength of wood members. This study was conducted to determine which dispersion statistics of annual ring width distributions measured in cross section in European oak ( Quercus robur L.) wood beams are useful as covariates in models for predicting modulus of elasticity ( MOE) and modulus of rupture ( MOR). For this purpose, 21 European oak trees growing in north-western Spain were felled, logged, and sawn. The planks obtained were air-dried and surfaced into beams (50 mm × 100 mm × 2000 mm), which were visually graded according to the UNE 56544:2022 standard. MOE, MOR, moisture content and density (determined according to EN 408:2010 standard) and abundance of sapwood and ring widths were determined in 30 beams apt for structural purposes. MOE was significantly related to standard deviation, variance and interquartile range of the ring width distribution in the beam. MOE was also related to mean ring width ( r = –0.52, p < 0.01) and maximum ring width per beam ( r = –0.54, p < 0.01), an easy to measure variable. MOR was also related to ring width distribution parameters, although yielding lower r values. The influence of ring width evenness and maximum ring width can be considered to improve visual strength grading standards for European oak timber.
Robustness of interferometric power to sudden death
Authors: Zhu Dian , Zhang Fu-Lin , Chen Jing-Ling
Published: November 2024

In this paper, we study the dissipative dynamics of interferometric power as a discord-like measure in Markovian environments such as dephasing, depolarizing, and generalized amplitude damping. Moreover, we compare the dynamics of interferometric power and entanglement by choosing the proper initial conditions. Our study shows that interferometric power decays asymptotically in all cases where the sudden death of entanglement appears. Therefore, quantum metrology based on interferometric power is more robust than entanglement.
INTEGRATING APPLIED LINGUISTICS WITH ARTIFICIAL INTELLIGENCE-ENABLED ARABIC TEXT-TO-SPEECH SYNTHESIZER
Authors: HASSAN ABDULKHALEQ Q. A. , ALANAZI MESHARI H. , AL-ANAZI REEMA G , ALZAIDI MUHAMMAD SWAILEH A. , ALJOHANI NOUF J. , ALZAHRANI KHADIJA ABDULLAH , ALZUBAIDI UMKALTHOOM , HILAL ANWER MUSTAFA
Published: November 2024

Currently, Text-to-Speech (TTS) or speech synthesis, the ability of the complex system to generate a human-like sounding voice from the written text, is becoming increasingly popular in speech processing in various complex systems. TTS is the artificial generation of human speech. A classical TTS system translates a language text into a waveform. Several English TTS systems produce human-like, mature, and natural speech synthesizers. On the other hand, other languages, such as Arabic, have just been considered. The present Arabic speech synthesis solution is of low quality and slow, and the naturalness of synthesized speech is lower than that of English synthesizers. Also, they lack crucial primary speech factors, including rhythm, intonation, and stress. Several studies have been proposed to resolve these problems, integrating using concatenative techniques like parametric or unit selection methods. This paper proposes an Applied Linguistics with Artificial Intelligence-Enabled Arabic Text-to-Speech Synthesizer (ALAI-ATTS) model. This ALAI-ATTS technique includes three essential components: data preprocessing through phonetization and diacritization, Extreme Learning Machine (ELM)-based speech synthesis, and Grey Wolf Fractals Optimization (GWO)-based parameter tuning. Initially, the data preprocessing step includes diacritization, where diacritics are restored to unvoweled text to ensure correct pronunciation, followed by phonetization, translating the text into its phonetic representation. Then, the ELM-based speech synthesis model uses the processed dataset for speech generation. ELMs, well known for their excellent generalization performance and fast learning speed, are especially suitable for real-time TTS applications, balancing high-quality speech output and computational efficiency. Lastly, the GWO methodology is employed to tune the parameters of the ELM. The simulation outcomes validate that the ALAI-ATTS technique considerably enhances the intelligibility and naturalness of Arabic synthesized speech compared to existing approaches. The experimental results of the ALAI-ATTS technique portrayed a lesser value of 3.48, 0.15 and 1.37, 0.25 under WER and DER.
Generalized derivations with powercentral values on Lie ideals and Banach algebras
Authors: Hermas Abderrahman , Oukhtite Lahcen
Published: November 2024

Let [Formula: see text] be a prime ring and [Formula: see text] a non-central Lie ideal of [Formula: see text] We aim in this paper to classify generalized derivations [Formula: see text] of [Formula: see text] satisfying the following algebraic identity: [Formula: see text] where [Formula: see text] [Formula: see text] in [Formula: see text] the extended centroid of [Formula: see text] and [Formula: see text] are fixed positive integers. Moreover, we extend our analysis to the semiprime ring [Formula: see text] and discuss applications such as deriving range inclusion results for continuous generalized derivations on Banach algebras.
On some weak versions of graded-Noetherian modules and rings
Authors: Assarrar Anass , Mahdou Najib , Teki̇r Ünsal , Koç Suat
Published: November 2024

In this paper, we introduce and investigate two weak versions of graded-Noetherian modules. Let [Formula: see text] be an abelian group with an identity element denoted by [Formula: see text], [Formula: see text] be a commutative [Formula: see text]-graded ring and [Formula: see text] be a [Formula: see text]-graded [Formula: see text]-module. We say that [Formula: see text] is a graded-r-Noetherian module if every graded-r-submodule of [Formula: see text] is finitely generated. Also, we say that [Formula: see text] is a graded-weakly-Noetherian module if all finitely generated graded submodules of [Formula: see text] are graded-Noetherian [Formula: see text]-modules. We give many properties of the two different concepts and we examine the relation between them and the different concepts that already exist in the literature. We illustrate our study by giving many nontrivial examples and counter-examples. Moreover, we characterize graded-Noetherian modules in terms of graded-r-Noetherian and graded-weakly-Noetherian modules. Finally, we examine the transfer of these two concepts in the graded idealization of graded modules.
An extension to characterize Jordan higher derivations on triangular rings
Authors: Hosseini Amin
Published: November 2024

The main goal of this paper is to extend the main result of [22] to non-unital triangular rings. Indeed, we prove that every Jordan higher derivation on a triangular ring is a higher derivation without requiring the existence of unity. As a remark, the modification of [12, Theorem 3] is also discussed.
KAMPO SI-SHEN EXTRACT PREVENTS LPS-INDUCED WORKING MEMORY IMPAIRMENT AND DEPRESSIVE BEHAVIOR IN MICE
Authors: Yeh Tsung-Ming , Sung Wei-Wen , Cheng Yi-Tso , Shih Wen-Ling
Published: November 2024

Si-Shen decoction is a mild medicinal dietary material composed of lotus seeds, gorgon, poria and yam. In vitro studies have proved the biological activity of four individual medicinal materials, but the effects of the combination prescription have yet to be evaluated in vivo in the past. This study prepared the Si-Shen extracts (SSE) by heating reflux with 50% alcohol. The prepared extracts contained functional components, including [Formula: see text][Formula: see text]mg of QE/g of flavonoids and [Formula: see text][Formula: see text]mg of GAE/g of polyphenols. The antioxidant activity of SSE was verified by the DPPH and FRAP assays. Moreover, the prepared SSE is not cytotoxic below the concentration of 2[Formula: see text]mg/mL according to the ISO10993-5 test method. Feeding the SSE for 28 days is sufficient to prevent lipopolysaccharide (LPS)-induced spatial memory impairment and anxiety symptoms, and SSE improves physical fitness. Further experiments demonstrated that SSE elevated the level of acetylcholine in the brain and serum superoxide dismutase activity. This research demonstrated the apparent efficacy and safety of the SSE, which will be further developed into innovative health products related to disease prevention.
ApSpGEMM: Accelerating Large-scale SpGEMM with Heterogeneous Collaboration and Adaptive Panel
Authors: Yao Dezhong , Zhao Sifan , Liu Tongtong , Wu Gang , Jin Hai
Published: November 2024

The
Sparse General Matrix-Matrix multiplication
(SpGEMM) is a fundamental component for many applications, such as
algebraic multigrid methods
(AMG), graphic processing, and deep learning. However, the unbearable latency of computing high-dimensional, large-scale sparse matrix multiplication on GPUs hinders the development of these applications. An effective approach is heterogeneous cores collaborative computing, but this method must address three aspects: (1) irregular non-zero elements lead to load imbalance and irregular memory access, (2) different core computing latency differences reduce computational parallelism, and (3) temporary data transfer between different cores introduces additional latency overhead. In this work, we propose an innovative framework for collaborative large-scale sparse matrix multiplication on CPU-GPU heterogeneous cores, named ApSpGEMM. ApSpGEMM is based on sparsity rules and proposes reordering and splitting algorithms to eliminate the impact of non-zero element distribution features on load and memory access. Then adaptive panels allocation with affinity constraints among cores improves computational parallelism. Finally, carefully arranged asynchronous data transmission and computation balance communication overhead. Compared with state-of-the-art SpGEMM methods, our approach provides excellent absolute performance on matrices with different sparse structures. On heterogeneous cores, the GFlops of large-scale sparse matrix multiplication is improved by 2.25 to 7.21 times.
Exploring AI-Based System for African Food Weight-Loss Recommendations
Authors: Ataguba Grace , Aworinde Halleluyah , Henry Kosi Clinton , Orji Rita
Published: November 2024

This research leverages artificial intelligence to design an African food recommendation system for weight loss. The rationale for designing this system was based on our recently published study on the design of socio-cultural food recognition systems for Africans. Based on our previous study, results revealed that users considered the socio-cultural food recognition system to provide nutritional value and would require a robust system with more African foods. Hence, to tailor our findings to effective dietary planning where obesity could be a concern, we propose the current system given the health implications of additional foods for specific users (that is, overweight users). Our current study is in three phases. The first phase will focus on validating some African foods with dieticians to determine their appropriateness for weight loss and better alternatives based on calories and other important metrics. Additionally, we will invite dieticians and some overweight users to evaluate some low-fidelity (Lo-fi) prototypes for the design requirement elicitation of the final prototype. The second phase will involve the development of our AI models (computer vision and large language models) and their evaluation. Furthermore, we will leverage the design requirements gathered from the lo-fi prototype study together with the AI models to develop a high-fidelity (Hi-fi) AI system that will run on mobile devices (the final prototype). Consequently, a post-study evaluation will be conducted with dieticians and overweight users to obtain subjective feedback. Hence, findings from this study will provide design recommendations for integrating African foods into existing and related large-scale AI-based systems in the future.
A Mobile Health Design Process to Improve User Engagement
Authors: Ikwunne Tochukwu
Published: November 2024

It has been shown that less than 25 percent of people continue to use health and wellness apps after the first time they use them. Despite the importance of user engagement for the efficacy of such apps and mobile health (mHealth) systems, many of these interventions frequently do not incorporate user-engaging attributes. This is partly because user needs and other sociocultural contexts are overlooked during the mHealth design, development, and implementation stages. These sociocultural contexts influence users' behaviours, and thus it is critical to capture this across the various stages of mHealth design and development. Based on this, a research gap was identified, leading to the development of the following research question targeting community health workers in Global South settings: How can a design framework be developed to improve community health workers (CHWs) engagement in mHealth technologies? The aim is PhD thesis is to develop an mHealth design process (or framework) called the Design Process Engagement Enhancement System (DECENT) which takes account of socio-cultural contexts in the design process of mHealth systems and improves community health workers' engagement with the designed mHealth technology. This framework is intended to be used by mHealth designers and developers in the field of mHealth. There are three contributions from this thesis. First, the expansion of O'Briens and Toms' engagement model. The process of expanding the engagement model resulted in the identification of engagement themes that have an impact on stages of engagement with mHealth that end users encounter in an mHealth setting. Second, this work makes an important contribution to practice. The DECENT framework is intended to be used by NGOs and mHealth practitioners. Finally, the contribution to theory by developing an analytical and methodological framework for analyzing frameworks based on activity the (AT) and communicative ecology framework (CEF).
Vision Transformer–Based Anomaly Detection Method for Offshore Platform Monitoring Data
Authors: Zhu Quanhua , Wu Qingpeng , Yue Yalin , Bao Yuequan , Zhang Tao , Wang Xueliang , Jiang Zhentao , Chen Haozheng
Published: November 2024

The structural health monitoring system for offshore platforms exhibits anomalies in the collected monitoring data due to its prolonged service in complex and harsh environments. These anomalies significantly impede data analysis and early warning capabilities. In order to realize efficient and intelligent anomaly detection for the monitoring data, a method based on the vision transformer (ViT) model is proposed. Firstly, the monitoring data are transformed into image files by segmentation and visualization. Subsequently, the image features are analyzed to identify the anomaly patterns and construct an image database, so that the data anomaly detection problem is transformed into a classification problem based on the image features. Lastly, the ViT model combined with convolutional neural network (CNN) is constructed. The local perception ability of CNN is utilized to extract the underlying image features and smooth the image features inputted into the ViT model, which improves the accuracy of the model. Validation using actual monitoring data shows that the proposed method can efficiently detect multiple types of anomaly patterns in the monitoring data with an accuracy rate of 93.1%.
Type III Secretion System in Intestinal Pathogens and Metabolic Diseases
Authors: Zhou Le , Zhang Yaoyuan , Wu Shiqi , Kuang Yiyu , Jiang Pengfei , Zhu Xiao , Yin Kai
Published: November 2024

Modern lifestyle changes, especially the consumption of a diet high in salt, sugar, and fat, have contributed to the increasing incidence and prevalence of chronic metabolic diseases such as diabetes, obesity, and gout. Changing lifestyles continuously shape the gut microbiota which is closely related to the occurrence and development of metabolic diseases due to its specificity of composition and structural diversity. A large number of pathogenic bacteria such as Yersinia, Salmonella, Shigella, and pathogenic E. coli in the gut utilize the type III secretion system (T3SS) to help them resist host defenses and cause disease. Although the T3SS is critical for the virulence of many important human pathogens, its relationship with metabolic diseases remains unknown. This article reviews the structure and function of the T3SS, the disruption of intestinal barrier integrity by the T3SS, the changes in intestinal flora containing the T3SS in metabolic diseases, the possible mechanisms of the T3SS affecting metabolic diseases, and the application of the T3SS in the treatment of metabolic diseases. The aim is to provide insights into metabolic diseases targeting the T3SS, thereby serving as a valuable reference for future research on disease diagnosis, prevention, and treatment.
Modeling of Hyperparameter Tuned Fuzzy Deep Neural Network–Based Human Activity Recognition for Disabled People
Authors: Alotaibi Faiz Abdullah , Alnfiai Mrim M. , Al-Wesabi Fahd N. , Alduhayyem Mesfer , Hilal Anwer Mustafa , Hamza Manar Ahmed
Published: November 2024

Human activity recognition (HAR) for disabled people is a vital research area, which aims to help individuals with disabilities in their daily lives. HAR involves using technology, typically wearable devices or sensors, to automatically identify and classify human activities and movements. HAR using deep learning (DL) is an effective and popular method to automatically classify and identify human activities based on sensor information. This article develops a hyperparameter tuned fuzzy deep neural network–based HAR (HTFDNN‐HAR) method. The objective of the HTFDNN‐HAR method lies in human activities identification and classification. In the presented HTFDNN‐HAR technique, cross‐guided bilateral filtering (CGBF)–based preprocessing is initially applied and MobileNetV3 architecture is applied for the effectual extraction of the feature vectors. In addition, the HTFDNN‐HAR technique makes use of the FDNN method for the efficient detection and classification of human activities. Finally, the HTFDNN‐HAR technique applies the manta ray foraging optimization (MRFO) technique for the optimum hyperparameter selection of the FDNN approach. A wide range of experiments have been carried out on the CAUCAFall dataset comprising 10,000 samples with two classes. The simulation value highlighted that the HTFDNN‐HAR technique reaches an enhanced accuracy of 99.40% over other recent approaches.
A Rare Case of Inflammatory Myofibroblastic Tumor Mimicking Fibrous Adhesions Resulting in Bowel Obstruction
Authors: Washburn Stephanie , Jessica Thomas Raj , Grider Douglas
Published: November 2024

Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumors of unknown etiology composed of myofibroblastic cells admixed with inflammatory cells. Presented is a 72‐year‐old male hospitalized for severe abdominal pain and hematochezia with onset of associated symptoms of fever and sweats a few hours prior to abdominal pain. A computed tomography (CT) demonstrated left colonic thickening interpreted as partial obstruction, gross adhesions, and ischemia. At surgery, marked bowel ischemia from the distal transverse to proximal sigmoid colon was seen with extensive gross adhesions. Histopathology revealed a mesenteric mass chiefly composed of stellate‐to‐spindled myofibroblastic cells and fibrous adhesions, intermixed with lymphocytes, histiocytes, and plasma cells. The tumor was positive for desmin, smooth muscle actin, and keratin; tumor staging, grade, and postsurgical follow‐up were not completed as the patient expired postoperatively. Illustrated is a rare pathologic mimic of ischemic colitis with fibrous adhesions, IMT. Thus, it should not be assumed that fibrous adhesions are always the etiology of obstruction when “adhesions” between sections of bowel are noted radiologically or surgically.
Healthcare Top Management’s Transformational Leadership Behaviors and Nurses’ Occupational and Organizational Turnover Intention: On the Role of Work Engagement and Autonomous Motivation
Authors: Gagnon Jean-François , Fernet Claude , Austin Stéphanie , Drouin-Rousseau Sophie
Published: November 2024

Aims: This study examines the contribution of top management’s transformational leadership behaviors on two targets of nurses’ turnover intention (organization and occupation) by focusing on the indirect (through vigor and dedication) and conditional indirect associations (involving autonomous motivation as a moderator).

Background: Although the issue of nurse turnover has received growing scientific attention, the research is currently silent about the specific targets of turnover intention and more importantly, the potential pathways through which top management’s transformational leadership behaviors relate to each target.

Method: Cross‐sectional data from a sample of 426 French–Canadian nurses and structural equation modeling were used to test the proposed model.

Results: Top management’s transformational leadership behaviors distinctly predicted organizational and occupational turnover intention through specific nurses’ states of engagement. While perceived transformational leadership positively predicted vigor, its indirect associations (via dedication) with organizational and occupational turnover intention depend on nurses’ level of autonomous motivation at work.

Conclusion: In times of nurse shortage, the present findings provide insights into how and when top management’s transformational leadership behaviors relate to nurses’ organizational and occupational turnover intention.

Implications for Nursing Management: Healthcare organizations are advised to foster top management transformational leadership behaviors and autonomous motivation to sustain the nursing workforce.
Supplementary Table S1 from NAD+ Metabolic Enzyme Inhibitor as Radiosensitizer for Malignant Meningioma and its Modulation of P53 Expression
Authors: Lv Yifan , Deng Yuxuan , Feng Jie , Liu Jinqiu , Yang Mingxu , Pu Zhuonan , Zhang Shaodong , Wu Zhen , Ji Nan , Park Deric M. , Hao Shuyu
Published: November 2024

Supplementary Table S1
Supplementary Figure S3 from NAD+ Metabolic Enzyme Inhibitor as Radiosensitizer for Malignant Meningioma and its Modulation of P53 Expression
Authors: Lv Yifan , Deng Yuxuan , Feng Jie , Liu Jinqiu , Yang Mingxu , Pu Zhuonan , Zhang Shaodong , Wu Zhen , Ji Nan , Park Deric M. , Hao Shuyu
Published: November 2024

Supplementary Figure S3
Supplementary Table 7 from Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases
Authors: Christensson Gustav , Bocci Matteo , Kazi Julhash U. , Durand Geoffroy , Lanzing Gustav , Pietras Kristian , Gonzalez Velozo Hugo , Hagerling Catharina
Published: November 2024

Differentially expressed genes between all TI ROIs and TC ROIs with log2-fold change, p-value and q-value, for comparison with all patients (first sheet) as well as comparison per patient (second sheet).
Supplementary Table 4 from Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases
Authors: Christensson Gustav , Bocci Matteo , Kazi Julhash U. , Durand Geoffroy , Lanzing Gustav , Pietras Kristian , Gonzalez Velozo Hugo , Hagerling Catharina
Published: November 2024

Count of identified phenotypes from the multiplex immunohistochemistry experiment, with proportions as a percentage of all identified cells.
Supplementary Figure S9 from Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases
Authors: Christensson Gustav , Bocci Matteo , Kazi Julhash U. , Durand Geoffroy , Lanzing Gustav , Pietras Kristian , Gonzalez Velozo Hugo , Hagerling Catharina
Published: November 2024

S9. Immune-MTC cellular Networks in Lung Cancer Brain Metastasis.
Supplementary Figure S7 from Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases
Authors: Christensson Gustav , Bocci Matteo , Kazi Julhash U. , Durand Geoffroy , Lanzing Gustav , Pietras Kristian , Gonzalez Velozo Hugo , Hagerling Catharina
Published: November 2024

S7. Differentially expressed (DE) genes for the immune infiltrate-associated TI ROIs.
Supplementary Figure S3 from Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases
Authors: Christensson Gustav , Bocci Matteo , Kazi Julhash U. , Durand Geoffroy , Lanzing Gustav , Pietras Kristian , Gonzalez Velozo Hugo , Hagerling Catharina
Published: November 2024

S3. Analysis of the immune landscape in human lung cancer brain metastases using the second reference dataset.
Supplementary Figure S2 from Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases
Authors: Christensson Gustav , Bocci Matteo , Kazi Julhash U. , Durand Geoffroy , Lanzing Gustav , Pietras Kristian , Gonzalez Velozo Hugo , Hagerling Catharina
Published: November 2024

S2. The immune landscape in lung cancer brain metastases.
Figure 6 from Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases
Authors: Christensson Gustav , Bocci Matteo , Kazi Julhash U. , Durand Geoffroy , Lanzing Gustav , Pietras Kristian , Gonzalez Velozo Hugo , Hagerling Catharina
Published: November 2024

Immune–MTC networks in lung cancer brain metastases. A, Estimated cell proportions in the lung cancer brain metastasis dataset according to bulk RNA deconvolution with our GeoMx dataset as reference for patients with intermediate or high CD45+ infiltration and with known time of death. B, Estimated cell proportions in the Rubio-Perez dataset (31) according to bulk RNA deconvolution with our GeoMx dataset as reference. C, Kaplan–Meier curves illustrating survival in our lung cancer cohort (i.), the Rubio-Perez and colleagues (31) cohort (ii.), and the TCGA primary lung cancer cohort (iii.), stratified by the estimated TI-Fb/Mc/P proportion amongst the samples. P values were calculated according to the log-rank test. D, Kaplan–Meier curves illustrating survival in our lung cancer cohort (i.), the Rubio-Perez and colleagues (31) cohort (ii.), and the TCGA primary lung cancer cohort (iii.), stratified by the estimated TI-FoB/ECD8+T/NK proportion amongst the samples. P values were calculated according to the log-rank test. BrM, brain metastasis.
Figure 4 from Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases
Authors: Christensson Gustav , Bocci Matteo , Kazi Julhash U. , Durand Geoffroy , Lanzing Gustav , Pietras Kristian , Gonzalez Velozo Hugo , Hagerling Catharina
Published: November 2024

Immune and metastatic tumor cell communication. A, Normalized gene expression for differentially expressed cytokines for each group of I-associated TI ROIs. Significant upregulation was defined as a log2FC of at least +0.75 and a q-value of less than 0.10. B, Plot of significant connections of inferred secreted signaling pathways between I and TI ROIs, weighted by communication probability. TI ROIs without an associated I ROI were excluded from the plot. C, Dot plot of the five TI to I interactions with the highest inferred probability per patient. D, Dot plot of the five I to TI interactions with the highest inferred probability per patient.
Arte e anatomia: do Renascimento à ilustração digital
Authors:   Universidade de São Paulo. Hospital Universitário, São Paulo, SP, Silva Adriano Ferreira da , Massari Catia Helena de Almeida Lima ,   Centro Universitário Facens, Sorocaba, SP
Published: November 2024

O estudo da Anatomia Humana a partir do Renascimento (aproximadamente entre os séculos XIV e XVI) foi marcado pelo ressurgimento do interesse pelas obras dos antigos médicos gregos e romanos. Hoje, o estudo da anatomia se beneficia, significativamente, das tecnologias digitais, que transformaram a forma como os estudantes e profissionais da área acessam, aprendem e aplicam o conhecimento anatômico. O presente livro tem como objetivo realizar uma reflexão sobre as obras artísticas selecionadas, produzidas desde a época do Renascimento até os dias atuais, criando uma visão sobre a interação e a comunicação entre a investigação em arte e ciências morfológicas. A ideia desta obra é não apenas desenvolver uma abordagem sobre a Anatomia e a Arte ao longo da história, mas também fazer uma reflexão sobre a própria história da Medicina, assim como os eventos da história ocidental atuaram e influenciaram o pensamento dos autores das obras citadas, seja por um lado positivo, seja por um viés negativo, conforme o leitor verá em alguns momentos da narrativa. Tudo isso ajudou a moldar o conhecimento sobre o corpo humano e, talvez, nos ajuda a pensar o que pode ser feito para melhorar não só as ações ligadas à saúde e ao ensino, bem como a nos entender como seres humanos.
Radiodrama em São Paulo: política, estética e marcas autorais no cenário radiofônico paulistano
Authors:   Universidade de São Paulo. Escola de Comunicações e Artes, Vicente Eduardo
Published: November 2024

Este livro apresenta alguns aspectos das pesquisas desenvolvidas na área de rádio desde 2006, ano de ingresso do autor no Departamento de Cinema, Rádio e Televisão (CTR) da Escola de Comunicações e Artes da Universidade de São Paulo. Nesse contexto e observando que são poucos os estudos sobre a história do rádio paulistano, a visão do conceito de “rádio possível” se desenvolveu e tornou-se uma estratégia de ensino, pesquisa e produção. O conceito parte da premissa de que as novas alternativas de produção e difusão sonora abertas pelas tecnologias digitais e, posteriormente, pelo advento da internet, tornaram fundamental a rediscussão crítica dos referenciais teóricos, da estética, das práticas de produção e da história do rádio no país, no sentido da busca de uma visão mais abrangente do veículo, que nos permita explorar as suas múltiplas possibilidades de uso social.
Aristóteles, Primeiros Analíticos II, 23-27: tradução e notas
Authors: Troster Tomás
Published: November 2024

This is an annotated translation of the last five chapters of the second book of Aristotle’s Prior Analytics. My aim is to provide Portuguese-speaking readers with a clear text, supplemented by materials that elucidate and contextualize Aristotle’s work, addressing a notable gap in the Lusophone bibliographical universe. To achieve this, I have based my translation on Ross’s edition of the Aristotelian text and compared it with various existing translations and commentaries.
Caronte Ocioso: ensaio sobre mortos e desaparecidos políticos
Authors: Panisset Vinicius
Published: November 2024

Este ensaio tem por objetivo analisar a privação de rituais fúnebres como uma das consequências do desaparecimento forçado de opositores políticos durante a Ditadura Civil-Militar no Brasil. A estratégia utilizada é efetuar um excurso histórico, breve e panorâmico, por diferentes períodos de modo a exemplificar a importância da realização desses ritos de passagem. Conclui-se que a ocultação dos cadáveres das vítimas e consequente impossibilidade da realização dos rituais fúnebres intensifica e prolonga a dor de familiares.
Jean-Baptiste Debret, cronista das Luzes
Authors: Andries Lise , Souza Maria das Graças de
Published: November 2024

O objetivo deste artigo é analisar a obra Viagem histórica e pitoresca ao Brasil, de Debret, e demonstrar que ele opera marcado pelas Luzes francesas. O texto está dividido em quatro partes, além da introdução e da conclusão: na primeira, apresenta o contexto histórico a partir do qual Debret se formou na pintura e recebeu as principais influências naquela arte; a segunda, aborda os aspectos técnicos de escrita da obra; a terceira toca no tema indígena; na quarta, problematiza a crônica urbana, com foco na cidade do Rio de Janeiro; a quinta e última, retoma a sua tese central: Debret olha o Brasil sob a perspectiva das Luzes.
Entre dois mundos: um exame da recepção de ideias da Revolução Francesa em Raízes do Brasil
Authors: Almeida Maria Cecília Pedreira de
Published: November 2024

There is no doubt that the Enlightenment principles of liberty, equality and fraternity have been very present in the history of several Ibero-American nations. In the case of Brazil, however, the state, guided by these noble ideals, has often engendered their opposite. The lack of certain essential services and guarantees for citizens in the Brazilian state is undeniable. Knowing the importance of such principles in Brazil, the aim is to understand how Sérgio Buarque de Holanda uses certain emblematic concepts of Enlightenment philosophy and what role they played, in his perception, in Brazilian political formation.
John Locke: entre a animalidade e a humanidade
Authors: Santos Antônio Carlos dos
Published: November 2024

The aim of this text is to analyse the arguments that Locke mobilises to demonstrate the difference between animals and humans, from the perspective of personal identity. It is divided into two parts: in the first, the presence of the parrot in Brazil will be evoked, from which Locke draws his example to discuss human identity, a task that will be developed in the second part. We hope to contribute to the debate on the relationship between humans and non-humans, particularly in the English seventeenth century.
Pascal, Rousseau e Kant: variações do pensamento dualista moderno
Authors: Figueiredo Vinicius de
Published: November 2024

Sabe-se do legado significativo de Blaise Pascal para as Luzes francesas. Voltaire lhe dedica a 25ª das Cartas filosóficas; Diderot lhe faz menção indireta, mas inequívoca, no título de seu primeiro escrito especulativo, os Pensamentos filosóficos (1745). No caso de Rousseau, a polêmica com o arcebispo de Beaumont expõe o que o separa do jansenismo – mas também o que o liga a Pascal, a saber: o emprego de categorias dualistas taus como natureza e história, princípio e processo, ser e dever ser. Por sua vez, Rousseau foi tomado por Kant como o “Newton da moral” já nos anos de 1760. Pretendo, nesse artigo, examinar se não há elementos conceituais comuns a Pascal, Rousseau e Kant, em torno da concepção dual que adotam para caracterizar a condição humana e sua relação com a práxis.
Merleau-Ponty dans les archives Husserl: entretien avec Emmanuel de Saint Aubert
Authors: Ramos Silvana de Souza , Santos Junior Iracy Ferreira dos
Published: November 2024

A entrevista concedida por Emmanuel de Saint Aubert a Silvana de Souza Ramos e a Iracy Ferreira dos Santos Junior aborda a história e o papel dos Arquivos Husserl de Paris para o fomento da pesquisa multidisciplinar em fenomenologia. O pensador esclarece qual foi o contato de Merleau-Ponty com os manuscritos de Husserl, e que tipo de leitura, situada e complicada, ele realizou não apenas desses manuscritos, mas da obra de Husserl como um todo. Esse aspecto é particularmente importante para os estudos de filosofia francesa contemporânea porque Merleau-Ponty foi um dos grandes responsáveis pela introdução de Husserl no pensamento francês. Tal esclarecimento permite mostrar a originalidade da filosofia de Merleau-Ponty, pois revela que o autor não era um exegeta de Husserl, mas um pesquisador inquieto e multifacetado, engajado nos debates intelectuais e políticos de sua época. Se ele não pode ser reduzido à figura de um mero leitor de Husserl, tampouco sua ontologia tardia pode ser resumida à influência de Heidegger. Debruçado sobre os manuscritos deixados inacabados por Merleau-Ponty em função de sua morte prematura, os quais eram um esboço de um novo livro, Saint Aubert realizou um minucioso trabalho de pesquisa dos usos que Merleau-Ponty faz de termos centrais de sua ontologia – chair, Leib, empiétement, quiasma – mostrando que eles não traduzem ou expressam literalmente conceitos provenientes de Husserl ou de Heidegger, pelo contrário, esses termos ganham uma gama de sentido multifacetada nos escritos de Merleau-Ponty, alimentando-se de suas leituras e meditações filosóficas, mas também de sua cultura científica e literária, e de suas preocupações éticas e políticas. A pesquisa de Saint Aubert, dedicada à interpretação dos chamados “inéditos” de Merleau-Ponty, resultou na publicação de cinco livros, pelas edições Vrin, todos eles guiados por uma leitura genética transversal da obra merleau-pontiana. Além disso, Saint Aubert, com a ajuda de outros pesquisadores e pesquisadoras, publicou, com apurado cuidado editorial, vários volumes com os manuscritos de Merleau-Ponty. Esse material, disponível de modo organizado e situado, é de uma riqueza incomparável, e permite dimensionar de modo mais preciso o papel de Merleau-Ponty no pensamento contemporâneo, além de iluminar o sentido de seu projeto ontológico.
Transcatheter Mitral Valve Replacement Using Annular Reduction by Cinching With TEER in the Commissure (ARCTIC)
Authors: Condos Gregory J. , Elison David , Vincent Logan L. , Harari Rafael , Sanina Cristina , Jelacic Srdjan , Sheu Richard , Chung Christine J. , Aldea Gabriel S. , Mackensen G. Burkhard , McCabe James M.
Published: November 2024

BACKGROUND:

Mitral annular calcification with valve dysfunction remains a challenging syndrome. Operative risk is high, and available transcatheter therapies are limited.

METHODS:

This study describes our initial experience with a novel procedure to address large mitral annuli when no surgical or trial-based transcatheter mitral valve replacement device is available. The rationale was to shorten the intercommissural distance using commissural mitral transcatheter edge-to-edge repair (TEER) followed by valve-in-mitral annular calcification transcatheter mitral valve replacement with a balloon-expandable aortic valve platform. Patients with long intercommissural distances and large mitral annulus areas were selected based on a high perceived risk of transcatheter valve embolization. Patients underwent mitral TEER with MitraClip in a commissural position, followed immediately by transseptal transcatheter mitral valve replacement with a 29 mm SAPIEN 3 valve.

RESULTS:

Thirteen patients were included. Median intercommissural distance and annular area were 39.1 mm and 930 mm
2
, respectively. Commissural mitral TEER was successful in all patients with no instances of single leaflet detachment. In 10 of 13 instances, an NTW device size was used. In 12 of 13 patients, valve implantation was successful, including 1 case that required a second valve for atrial positioning of the first valve. In 1 case, frank valve embolization into the left atrium occurred. Among the 12 successful cases, paravalvular leak was 1+ or less, and there were no instances of paravalvular leak adjacent to the TEER device.

CONCLUSIONS:

In patients with large annuli and sufficient annular calcium, a hybrid mitral TEER and valve replacement with the SAPIEN platform can be successfully used to facilitate transcatheter mitral valve replacement.
Care Quality and Outcomes of Ischemic Stroke in Patients With Premorbid Dementia: Get With The Guidelines-Stroke Registry
Authors: Ganesh Aravind , Wang Meng , Schwamm Lee H. , Fonarow Gregg C. , Messé Steven R. , Xian Ying , Saver Jeffrey L. , Smith Eric E.
Published: November 2024

BACKGROUND:

Patients with premorbid dementia have been generally excluded from trials of stroke therapies, and their dementia diagnosis may affect the care received. There are few data on the quality of stroke care and outcomes in these patients.

METHODS:

We compared the quality of care and outcomes for acute ischemic stroke patients with versus without premorbid dementia using national data from the Get With The Guidelines-Stroke registry between July 1, 2020, and December 31, 2021. Process outcomes included receiving intravenous thrombolysis, endovascular thrombectomy, and additional national quality measures. Clinical outcomes included ambulatory status at discharge, discharge destination, and mortality. The analyses were adjusted for patient and hospital characteristics.

RESULTS:

Among 609 350 patients with acute ischemic stroke, 29 751 of 546 407 (5.4%) had documented prestroke dementia (median age, 84 [interquartile range, 78–89]; 62.8% female). Patients with versus without premorbid dementia were more likely to arrive via emergency medical services (70.5% versus 46.8%) and had more severe strokes (median National Institutes of Health Stroke Scale score, 7 [interquartile range, 3–15] versus 3 [interquartile range, 1–8]). They were less likely to be admitted to a comprehensive stroke center (17.9% versus 22.7%;
P
<0.0001), to receive intravenous thrombolysis (9.6% versus 11.1%; adjusted odds ratio [aOR], 0.91 [95% CI, 0.87–0.95]) or endovascular thrombectomy (4.5% versus 7.4%; aOR, 0.62 [95% CI, 0.56–0.68]), attain each of the Get With The Guidelines-Stroke Achievement Measures and Quality Measures, or attain defect-free stroke care (92.0% versus 95.0%; aOR, 0.75 [95% CI, 0.71–0.78]). Patients with premorbid dementia had longer door-to-needle times (adjusted difference, 3.17 minutes [95% CI, 1.34–5.01]), lower odds of being discharged home (43.8% versus 60.1%; aOR, 0.96 [95% CI, 0.93–1.00]), and higher odds of being nonambulatory at discharge (25.8% versus 9.3%; aOR, 1.62 [95% CI, 1.54–1.69]), and of in-hospital mortality or hospice admission (23.3% versus 8.6%; aOR, 1.38 [95% CI, 1.32–1.43]). Symptomatic intracranial hemorrhage after intravenous thrombolysis/endovascular thrombectomy did not differ (5.3% versus 3.7%; aOR, 1.13 [95% CI, 0.97–1.31]).

CONCLUSIONS:

Patients with premorbid dementia experienced slightly poorer quality of stroke care across multiple measures, were less likely to receive acute stroke interventions, and had worse poststroke outcomes than patients without dementia in a large nationwide registry. Our findings underscore the need for concerted efforts to further improve care quality and outcomes in this population.
Understanding the anatomical diversity of leaves in the Aspicarpoid clade: New insights for Malpighiaceae systematics
Authors: VILARINHO MILENA PEREIRA , CÂMARA ANTONIA RITA DE MORAES , SANTOS JOÃO VICTOR DA COSTA , ARAÚJO JOSIANE SILVA
Published: November 2024

The Aspicarpoid clade represents a strongly supported group within the Stigmaphylloid lineage. The group is composed of four neotropical genera: Aspicarpa Rich., Gaudichaudia Kunth, Janusia A.Juss. and Peregrina W.R.Anderson. In this study, we studied the utility of leaf anatomy characters to support groups recovered in molecular phylogenies and define synapomorphies that can be used in future infra- and supra-generic classifications. Camarea axillaris A.St.-Hil. (1823: 10) and Cottsia Dubard & Dop (1908: 20) were used as outgroups for comparison. Dry leaf samples were re-hydrated, sectioned, stained, and analyzed using a microscope and a stereomicroscope. Characters such as presence and absence of glands, their location and morphotype, petiole and midrib contour, presence of trichomes, accessory bundles, vascular system organization and mesophyll type were utilized for species comparison, showing high taxonomic value for the group. Leaf glands, accessory bundles, sheath extension in the mesophyll and presence of druses and prismatic crystals were the most valuable characters in an evolutionary approach for the clade. Our work confirms the power of leaf anatomy as a taxonomic and evolutionary tool in Malpighiaceae Juss. (1789: 252), as well as its contribution to the delimitation of phylogenetic groups in the Aspicarpoid clade.