bluuebunny/crossref_metadata_2025 huggingface dataset:
Removal of Heavy metal ions using Nano-cellulose prepared from rice husk: Validation by Differential Pulse Voltammetry
Authors: Baraskar P. N. , Samant R. A. , Gurav V. L.
Published: August 2023

In this work Cellulose was extracted from rice husk and chemically modified to produce Nano-Cellulose. It was characterized by FTIR, XRD, SEM/EDS, TEM, BET surface area analyzer, Particle size analyzer and tested for the removal of metal ions i.e. Zn(II), Cd(II), As(III),Pb(II) and Sn(II) from aqueous solution. The removal method was validated by differential pulse voltammetry (DPV). Adsorption experiment was performed to investigate effects of initial pH, adsorbent dose, contact time and initial concentration of heavy metal ions on the adsorption capacity of nanocellulose. The experimental results revealed that the removal of metal ions on the nanocellulose was a pH-dependent process with the maximum adsorption capacity at the initial solution pH of 5–6. Adsorbent dose of 8mg/mL was sufficient for effective adsorption. In addition, the kinetics and equilibrium data are well described by pseudo-second-order kinetics and the Freundlich adsorption isotherm model at 50 min contact time and 50 mg/L initial concentration. Moreover, the desorption and re-adsorption performance was also studied, and the results revealed that the Nano-cellulose still showed good adsorption performance up to eight cycles of regeneration.
Development and psychometric properties testing of the educational need- assessment questionnaire for army healthcare providers to provide care for mothers and newborns in disasters
Authors: Poursoleiman Leila , Pishgooie Amir hosein , Aliyari SHahla , Sharififar Simin Taj
Published: August 2023

Background
To develop a curriculum for healthcare providers to provide care for mothers and newborns in disasters, they must first assess educational needs and then develop training content based on educational needs. This study aimed to construct and assess the validity and reliability of the educational need-assessment questionnaire for healthcare providers for mothers and newborns in disasters.
Methods
In this methodological study, after conducting web and library studies and cultural attention, a questionnaire was set up, and face validity, content validity, and construct validity were assessed. Second, internal constancy and stability were measured as a function of reliability. At this stage of the study, 208 healthcare providers from selected hospitals in the city of Tehran were selected and participated. SPSS version 16 was used for data analysis.
Results
The questionnaire was developed into 64 items. The face and content validities were acceptable. Exploratory factor analysis was fitted and showed ten factors. All of the items in a factor were compatible with each other, so the items were put into ten factors, and choosing the fit name for each factor was possible. These 10 factors explained 75/3% of the total variance of the test. The total scale showed an alpha Cronbach of 0/94.
Conclusion
The findings indicate that the current questionnaire entitled "Educational needs assessment for healthcare providers for mothers and newborns in disasters" with 64 items has appropriate reliability and validity and can be used in different settings by curriculum planners as a suitable tool for assessing the educational needs of healthcare providers for mothers and newborns in disasters.
Genetic parameters and responses associated with high temperature in potato wild relatives.
Authors: Bashir Ikram , Nicolao Rodrigo , Shimoia Eduardo Pereira , Amarente Luciano do , Castro Caroline Marques , Heiden Gustavo
Published: August 2023

Crop wild relatives (CWRs) have significantly been used in potato (Solanum tuberosum, Solanaceae) breeding. Hence, introgression breeding may help in coping with the challenges posed by climate change. We used 20 accessions from Embrapa Potato Genebank, twelve belongs to wild specie Solanum chacoense and eight from S. commersonii and one, S. tuberosum commercial cultivar for their tolerance to two different temperature conditions CT as control temperature (14–24ºC) and HS as heat stress (24–37ºC). The evaluation was based on gas exchange (Pn, Gs and Tr), chlorophyll fluorescence analysis (Y(II), NPQ, Fv/Fm), chlorophyll A, B and carotenoid content and tuber yield related traits (FTW and DMC%) and measured after 1DAS (Days after stress), 15DAS and 35DAS. Mixed model methodologies were used to predict average genotypic value in the various environments and capitalize on an average interaction with all evaluated environments. Significant differences were observed between Solanum wild genotypes showed by 2-factorial for agronomic traits and 3-factorial ANOVA for physiological traits. The correlations among the accessed traits were found here significant for heat stress conditions. Mixed model methodology helps us ranking the genotypes based on measured variables according to their true genotypic values for both temperature conditions and after each measurement of days after applied stress.
Phytochemical investigation of anti-proliferative active fractions of Cannabis sativa leads to isolate a new Compound Canniprene A and other bioactive compounds through bioassay guided fractionation and HPLC assisted purification
Authors: Nalli Yedukondalu , Bharti Sahil , Amin Tanzeeva , Singh Rohit , Behera Jayaprakash , Goswami Anindya , Verma Mahendra Kumar
Published: August 2023

Phytocannabinoids and synthetic cannabinoids have been explored as the lead due to their anti-proliferative nature and can be anti-cancer agents. These were found to activate numerous pharmacological targets to generate new therapies in alleviating specific symptoms or delaying the disease of Cancer. However, the comprehensive anti-cancer activities of cannabinoid acids and non-cannabinoids are not fully explored. Herein we report simple extraction, faster bioassay-guided fractionation, and HPLC-assisted purification of bioactive secondary metabolite and their identification. Anti-proliferative activity of six cannabinoid acids (CBDA’s) and eleven non-cannabinoids from the leaves of Cannabis sativa was evaluated. HPLC- assisted purification from the bioactive fractions leads to isolate one new compound Methoxy Canniprene (methoxy isoprenyl bibenzyl), including all six CBDA’s eleven non-cannabinoids in a single step, and NMR, HR-ESI-MS studies, and comparison with the literature data authenticated their structures. The crude extract (IC50 range: 18.0–37.2 µg/mL), Fraction A to D (11.9 to 222 µg/mL), and purified different cannabinoid and non cannabinoids (IC50 range: 0.5–100 µM) displayed potent anti-proliferative activities against almost all the tested five human cancer cell lines.
The contribution and interplay of implicit and explicit processes on physical activity behavior: Empirical testing of the Physical Activity Adoption and Maintenance (PAAM) model
Authors: Jekauc Darko , Gürdere Ceren , Englert Chris , Strobach Tilo , Bottesi Gioia , Bray Steven , Brown Denver , Fleig Lena , Ghisi Marta , Graham Jeffrey , Martinasek Mary , Tamulevicius Nauris , Pfeffer Ines
Published: August 2023

The adoption and maintenance of physical activity (PA) is an important health behavior. This paper presents the first comprehensive empirical test of the Physical Activity Adoption and Maintenance (PAAM) model, which proposes that a combination of explicit and implicit self-regulatory processes is involved in PA adoption and maintenance. Data were collected via online questionnaires in English, German, and Italian at two measurement points four weeks apart. The study included 422 participants (Mage= 25.3, SDage= 10.1; 74.2% women) from Germany, Switzerland, Italy, Canada, and the U.S. The study results largely supported the assumptions of the PAAM model, indicating that intentions and habits significantly mediate the effects of past PA on future PA. In addition, the effect of past PA on future PA was shown to be significant through a mediation chain involving affect and habit. Although the hypothesis that trait self-regulation moderates the intention-behavior relationship was not supported, a significant moderating effect of affect on the same relationship was observed. The results suggest that interventions targeting both explicit and implicit processes may be effective in promoting PA adoption and maintenance.
The use of the Baumber scoring system for metastatic disease of the vertebral column
Authors: Hodgson Sam , Pynsent Paul , Hughes Simon , Rehousek Petr , Gardner Adrian
Published: August 2023

Objective
The prognostic assessment of patients with metastatic spinal disease is predominantly tumour rather than patient based. Baumber et al have published a prognostic scoring system based on the patient rather than the tumour for metastatic disease of the appendicular skeleton. This paper assesses that formula for metastatic disease of the spine.
Results
Survival was recorded for 65 individuals who underwent surgery for metastatic disease of the spine. Using the same parameters as Baumber, the projected survival was longer than that recorded in their cohort (over-prediction of 39% at 6 months and 54% at 12 months). The relative contributions of the individual parameters as part of the overall survival was different between the groups with a greater contribution seen if the individual had hyponatraemia, hypoalbuminaemia and low levels of creatinine. The reasons for the differences seen between the spinal and appendicular groups with regards to these parameters are not clear but may represent a poorer level of general health. Further work is required to develop a specific tool for the calculation of prognosis in a metastatic spinal cohort using a general health perspective.
End-on Versus Parallel Radiofrequency Lesioning for Neurotomy of the Cervical Medial Branch Nerves: A Study Protocol of a prospective, randomized, Double-Blind Clinical Trial: The “EndPaRL” Study
Authors: Alomari Abeer , Ferreira-Dos-Santos Guilherme , Singh Mandeep , Burnham Taylor , Cao Xingshan , McCormick Zachary , Flamer David , Kumar Pranab , Hoydonckx Yasmine , Khan James S. , Bhatia Anuj
Published: August 2023

Background
Cervical facet joint disease is a common source of neck pain and its prevalence increases with aging. Conservative multimodal management options (e.g., strengthening of neck muscles, non-steroidal anti-inflammatory medications, massage, and thermal modalities) often fail to relieve pain. Cervical medial branch nerve (CMBN) radiofrequency neurotomy (RFN) is an effective minimally invasive technique for treating chronic neck pain secondary to facet joint disease. An end-on approach for this procedure has been proposed that may be technically easier and require less time while reducing post-procedural discomfort. The protocol presented here is for a study that aims to compare the efficacy of a new end-on approach using multi-tined cannulae, against the conventional parallel technique that employs straight cannulae for RFN of the CMBN in patients with chronic neck pain due to cervical facet joint disease.
Methods
A multicentre randomized, non- inferior, active comparator-controlled trial will be conducted with two parallel groups and blinding of participants and outcome assessor. The study will include 72 adults with chronic neck pain secondary to facet joint disease who are candidates for RFA of the CMBN. Participants will be randomized to either the conventional parallel or the end-on approach in a 1:1 ratio. The intensity of pain and pain-related domains (function, quality of life, sleep, adverse effects of the interventions, analgesic intake) will be measured at one, three, six, and 12 months after the procedure.
Discussion
Neck pain secondary to cervical facet joint disease is prevalent and RFA of the CMBN is a validated treatment for relieving it. The conventional parallel technique can be technically challenging, and it can be associated with adverse effects while the newer end-on approach has the potential of being a simpler technique with less adverse effects. This trial will be the first non-inferiority study to compare the clinical efficacy of the end-on approach against the conventional parallel approach for RFN of CMBN in patients with chronic neck pain due to cervical facet joint disease.
Trial registration
ClinicalTrials.gov NCT05818774. Registered on April 20, 2023
Prognostic Factors of Oligometastasis after Stereotactic Body Radiotherapy: Real-world Utility of the European Society for Radiotherapy and Oncology/European Organisation for Research and Treatment of Cancer Classification
Authors: Bessyo Ryosuke , Uezono Haruka , Ota Yosuke , Miyazaki Shuichiro , Marudai Mitsuru , Takabayashi Hatamei , Tsujino Kayoko
Published: August 2023

Background
The efficacy of local therapy for oligometastatic disease (OMD) remains unclear. This study aimed to evaluate the prognostic utility of the classification system for OMD and explore which groups may benefit from stereotactic body radiation therapy (SBRT).
Methods
The single-center retrospective study included 48 patients (55 sites) with solid tumors and 1–3 extracranial oligometastases, who underwent SBRT for all metastases at our institution between January 2018 and December 2021. OMD states were classified based on the European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer classification system. Local control (LC), overall survival (OS), and progression-free survival (PFS) for each group were analyzed using the Kaplan–Meier method. Acute and late adverse events (AEs) were evaluated.
Results
The median follow-up period was 14 months (range, 0–48 months). The number of patients in the de-novo, repeat, and induced OMD groups were 16, 19, and 13, respectively. The LC rates at 1-year for the entire, de-novo, repeat, and induced cohorts were 87.9%, 88.2%, 90.9%, and 83.9%, respectively. The 1-year PFS and OS for each group were 38.9%, 81.2%, and 61.0% and 87.1%, 29.9%, and 80.8%, respectively. Grade 2 or higher AEs occurred in five patients (10.4%). No grade 4 or 5 AEs were observed.
Conclusions
SBRT in patients with OMD was safe and highly effective for local control. Patients with repeat OMD demonstrated better PFS than other OMDs.
Outcomes of adult native liver survivors with biliary atresia: the current situation in Japan
Authors: Kawaguchi Yunosuke , Terui Keita , Takenouchi Ayako , Komatsu Shugo , Saito Takeshi , Hishiki Tomoro
Published: August 2023

Purpose: This study aimed to elucidate the difficulties faced by adult native liver survivors with biliary atresia (BA) in Japan.
Methods: A single-center, retrospective, observational study of 57 adult patients with BA was conducted. The clinical course of BA was compared between native liver survivors and non-survivors who reached adulthood. Indications and outcomes of liver transplantation (LT) among non-survivors were assessed.
Results: A significantly larger portion of non-survivors (n=10) met the criteria for LT
(p <0.001) and received treatment for portal hypertension after reaching 20 years of age (p <0.01) compared with the survivors. Causes of death included liver cirrhosis (n=8), graft failure of living donor liver transplantation (LDLT) (n=1), and hepatocarcinoma (n=1). Two of the non-survivors who died of liver cirrhosis had no indication for LT because of alcohol dependence and uncontrolled infection. An appropriate donor candidate could not be found for the five patients who opted for LDLT. All six patients waitlisted for deceased donor liver transplantation (DDLT) died after a median waiting period of 17 months.
Conclusion: Adult BA patients in Japan have limited options for LT, mainly owing to low donor candidate availability for LDLT and a low prevalence of DDLT.
A Bioinformatic Analysis Reveals Commonly Dysregulated Genes and Pathways in Multiple Cancers Treated with Metformin
Authors: Rahmani Mohammadreza , Jalili Ali , Moradzad Mohammad , Fakhari Shohreh
Published: August 2023

Metformin, a prescribed medication for diabetes, has exhibited anti-cancer effects. In this study, we conducted an extensive bioinformatic analysis aiming to reveal effects of metformin on gene modulation in four distinct types of cancer: head and neck, liver, pancreatic, and prostate cancer. By integrating publicly available gene expression data from Gene Expression Omnibus (GEO) and enrichment analysis methods, we identified genes and pathways associated with the anti-cancer activities of metformin. We observed a significant upregulation of the genes NFKBIA and GADD45A, which are known to be involved in pathways linked to cancer progression. Moreover, we identified that MTHFD2 appears to be a biomarker for all these types of cancers and a target for metformin. Furthermore, the gene DKK1 exhibited potential as a prognostic indicator specifically for head and neck and pancreatic cancer, highlighting its clinical importance in these cancer types. In conclusion, our bioinformatic analysis suggests that metformin possesses anti-cancer activities through modulations of the NFKBIA, GADD45A, MTHFD2, and DKK1 genes which our study reveals for the first time their association with metformin in context of cancer. Our data contribute to understanding of the mechanism of anti-cancer activity of metformin.
Computer vision-based monitoring method of non-wearing helmet events using face recognition
Authors: Liao Chenrui , Chen Hongyan , Liu Chenxi , Yu Ying , Zhao Pengfei
Published: August 2023

Wearing helmets is crucial for ensuring the safety of workers in the construction industry because this is the first line of avoiding over 70% of production safety accidents. However, many workers are not willing to wear helmets due to discomfort and reduced work efficiency. To this end, this paper proposes a computer vision-based monitoring method using face recognition to detect and prevent non-wearing helmet events on construction sites. Compared to existing surveillance or monitoring systems, the proposed method has three significant advantages. Firstly, by using a unique structure, the proposed method can achieve up to 97.7% accuracy in detecting workers not wearing helmets. Secondly, the proposed method enables real-time detection, allowing it to prevent dangerous behaviors by stopping them in advance. Finally, the proposed method has been successfully deployed on over 20 real construction sites, and it has detected more than 18,000 related events.
Upgrading mixed plastic wastes to prepare wood plastic composites via solid mechanochemical method
Authors: Jiang Qingquan , Yang Fang , Nie Min , Chen Ning , Han Dan , Liu Bo , Cheng Liping
Published: August 2023

Plastic wastes are integrated with renewable wood fiber (WF) into wood-plastic composites (WPC), which is an economically sustainable way to solve global plastic pollution. However, the current processing strategies are applied mainly to single-polymer wastes, but are ineffective for mixed-waste streams. Herein, we proposed a simple and effective strategy to upcycle mixed plastic wastes to prepare WPC via solid-state shear milling (S3M). Specially, the mixed plastic waste, WF and maleic anhydride grafted polyethylene were co-milled in solid-state. During the mechanical treatment, the bevel ridges on the upper and lower pans in the S3M equipment created many mixing units to continuously exert strong squeezing and shearing forces on the milling composites, enabling mechanically-induced pulverization, dispersion and esterification of the multi-component materials at room temperature. As a result, the mixed plastic wastes with WF were pulverized and mixed simultaneously while hydrophilic WF was transformed to the hydrophobic one, endowing the obtained WPC with exhibited excellent processability and strong interfacial interaction. The flexural strength and modulus reached 39.5 MPa and 4257 MPa, with 72% and 101% enhancement compared to the WPC sample with the same formulation prepared by direct melt-process. This mechanochemistry technology can successfully achieve the upgrading and reuse of mixed plastic wastes and solve the challenges associated with the WF preparation, which plays a crucial role in mitigating plastic pollution.
Both frequency and diversity of childhood nature experiences are associated with self-reported pro-biodiversity behaviors in adulthood
Authors: Aota Yutaro , Soga Masashi
Published: August 2023

The ongoing degradation of Earth’s ecosystems through human activities poses a severe threat to biodiversity. To mitigate this crisis, substantial changes in human behavior are required. The frequency of nature experiences, particularly during childhood, has been established as a key predictor of actions that support biodiversity (hereafter, pro-biodiversity behaviors). However, the significance of the quality of these experiences remains poorly understood. In this study, we analyzed a large sample of Japanese adults and observed positive associations between both the frequency and diversity of nature experiences during childhood and increased pro-biodiversity behaviors. These associations held true across a range of behaviors, including the purchase of eco-friendly products, reduced use of pesticides in domestic gardens, and contributions to conservation organizations. Our findings indicate that the association between pro-biodiversity behaviors and the diversity of childhood nature experiences is comparable to that of the frequency of such experiences. These findings suggest that expanding people’s access to diverse and frequent nature experiences can play a crucial role in promoting positive behavioral changes to prevent biodiversity loss.
The first identification of cronstedtite in Cu–Ni–PGE ores of the Talnakh intrusion
Authors: Yakich T. Yu. , Zhimuleva E.S. , Rudmin M.A. , Ruban A.S. , Maximov P.N. , Shaldybin M.V.
Published: August 2023

We present new mineralogical data of cronstedtite from the Southern-2 orebody, located in the South-Western branch of the Talnakh intrusion (Noril'sk camp) composed of massive sulfides in which the total amount of oxides and silicates does not exceed 1–3 vol. %. The petrographic and mineralogical features of these ores indicated occurrence of fine-grained, fibrous needle like clusters <50-µm-sized grains of cronstedtite (7,09 Å along its c-axis). This mineral confirmed by a number of analytical techniques (powder X-ray diffraction of balk samples, transmission electron microscopy, scanning electron microscopy, Raman and Infrared spectroscopy). Cronstedtite contains impurities of Al, Ni, Ca and filling the cracks between sulfides of copper (chalcopyrite) and iron (pyrrhotite, pentlandite, troilite). In some cases, cronstedtite contains micron-sized PGE, and associates with magnetite, kaolinite, gypsum, calcite, quartz, and cristobalite. The findings of cronstedtite in Noril'sk camp have never been mentioned publicly before. Its occurrence is the northernmost known locality in the world. Our results imply that the formation of cronstedtite in the Talnakh intrusion could be possible by the active participation low-temperatures fluids within the relatively near-surface (<2 km of paleosurface) conditions of intrusion emplacement, in contrast to other deep-seated supergiant Cu-Ni-PGE deposits in the world.
Gut microbiota influence on pulmonary arterial hypertension risk: a Mendelian randomization analysis
Authors: Li Dongrui , Li Fan , Jin Jingyu , Yang Yang , Tong Qian
Published: August 2023

Background
The association between gut microbiota and pulmonary arterial hypertension (PAH) has been found in some observational studies. However, whether this association implies a causal relationship remains unclear.
Methods
In this study, we employed summary data from genome-wide association studies (GWAS) of the gut microbiota and PAH to investigate the causal relationship between the gut microbiota and PAH using a two-sample Mendelian randomization (MR) design. Comprehensive sensitivity analyses were conducted to ensure the robustness of the results.
Results
The MR results indicated that genetically predicted abundance of Lachnospiraceae ND3007 group (OR (95% CI):0.251(0.175 ~ 0.360), adjusted P value:<0.001) and Eubacterium fissicatena group (OR (95% CI):0.525(0.411 ~ 0.669), adjusted P value:<0.001) were significantly associated with a reduced risk of PAH. Additionally, we identified 12 gut microbiota, including Eubacterium ventriosum and Ruminococcus torques, that may have potential causal relationships with PAH.
Conclusion
This study suggests that specific gut microbiota may influence the incidence of PAH. This provides the evidence for a causal relationship between gut microbiota and PAH, thus offering novel insights into the therapeutic and mechanistic research of PAH.
Partial Diffusion LMS for Distributed Estimation over Fading Wireless Channels
Authors: Moallem Mohammadjavad Mirzazadeh , Korki Mehdi
Published: August 2023

In this paper, we present a study on partial-diffusion least mean-square (PDLMS) strategy in distributed wireless sensor networks (WSNs) in presence of wireless channel impairments, such as path loss, fading, and additive noise. Our main focus is to demonstrate the stability of the PDLMS algorithm in both the mean and mean-square sense, even in the presence of channel distortion. Additionally, we analyze the convergence behavior of the algorithm under these challenging conditions. To further enhance the performance of PDLMS over fading channels, we propose an optimal combination matrix obtained by minimizing the steady-state mean-square deviation (MSD). This matrix allows us to mitigate the performance degradation resulting from wireless channel distortions.The efficacy of our proposed optimal PDLMS method is validated through extensive simulations, which provide substantial evidence supporting the theoretical findings of this study.
AutomaticSelf Balancing Robot for Crop Monitoring
Authors: Shukla Rachel , R Anand , Ramprabhakar J
Published: August 2023

The Automatic Self Balancing Robot for Monitoring of Crop is a novel robotic system designed for the agricultural industry to improve crop monitoring and management. The robot is equipped with sensors, cameras, and machine learning algorithms that enable it to navigate through fields, collect da-ta on plant health, and identify potential issues here in this case fruit ripening (Early ripe, partially ripe, Ripe and Decay) with the help of camera. The self-balancing feature of the robot allows it to operate on uneven terrain, ensuring stable and accurate data gathering. Data gathered by the robot such as tempera-ture, humidity and soil moisture are sent to a central system for analysis, ena-bling agricultural producers to decide on crop management. The use of this ro-botic system can increase productivity, reduce employment costs, and improve overall harvest yields PID control, a feedback control loop, modifies the robot's behaviors in response to the discrepancy between the desired and actual states. A mathematical process called Kalman filtering is used to calculate and remove noise from sensor measurements, enabling more precise data interpretation. To improve the overall impression of the robot's orientation, sensor fusion com-bines data from several sensors, such as gyroscopes and accelerometers. IMUs are sensor bundles with integrated sensors that provide information on rotation, acceleration, and magnetic field strength, allowing for accurate measurement and control.
Implementation of Cloud Assisted Optical Sensor System for Smart City Environment Using IoT Assistance
Authors: Alqahtani Abdulrahman Saad
Published: August 2023

One of the most crucial strategies for allowing us to carry on with normal life both during and after the pandemic is the smart city. The goal of the smart city is to serve the community and enhance the services offered to the populace, particularly in areas as important as health, education, electricity, transportation, and communications. The Internet of Things (IoT) platform offers seamless data transmission and analysis in real time between optical devices and the cloud infrastructure. Cities may enhance several areas of urban life, such as traffic control, video surveillance, environmental monitoring, and infrastructure maintenance, by utilizing the power of optics and IoT. Optical sensors can detect air quality, noise levels, and weather conditions, providing important information for environmental management and public health programs. Intelligent analytics-equipped video surveillance cameras can improve security by spotting and immediately notifying authorities of questionable activity. This research covers two cutting-edge IoT applications for smart cities: The first involves creating an intelligent health monitoring system that aims to lessen work strain on the medical personnel and the spread of Coronavirus infection from patients to the medical staff. The second use deals with measuring and monitoring electrical characteristics and energy consumption to keep track of electrical energy used. Additionally, knowing the trespasser on the electrical line is helpful. Both systems collect data from sensors in real time and send it to a server.
Child-Sum (N2E2N)Tree-LSTMs: An Interactive Child-Sum Tree-LSTMs to Extract Biomedical Event
Authors: Wang Lei , Cao Han , Yuan Liu , Cui Yachao , Yu Hongli , Sun Pengfei
Published: August 2023

Background
LSTM has been presented to overcome the problem of the gradient explosion and explosion. Tree-LSTM could improve the parallel speed of LSTM, and incorporate relevant information from dependency or syntax trees. Tree-LSTM can update gate and memory vectors from multiple sub-units. Learning edge features can strengthen the expression ability of graph neural networks. However, the original Child-Sum Tree-LSTMs ignores edge features during aggregating the sub-nodes hidden states.
Methods
we propose an interaction mechanism that can alternately updating nodes and edges vectors, thus the model can learn the richer nodes vectors. The interaction mechanism attaches the node embedding to its connected link at the first stage. Next, it superimposes the updated edge into the parent node once more. Repeat the above steps from bottom to top. We present five strategies during the alternant renewal process. Meanwhile, we adopt two constituent parsers and two dependency parser to produce the diversified formats, and compare their performances in the experiment result.
Results
The proposed model obtains the best performance compared with other methods on the BioNLP’09 and MLEE corpuses.
Conclusion
The experimental results confirm the effectiveness of the interactive mechanism. The parsing results have little impact on the final model performance, but different parsing formats have different results. CoNLL’2008 Dependencies show competitive and superior performance for each parser.
Boundary value problems in a theory of bending of thin micropolar plates with surface elasticity
Authors: Gharahi Alireza
Published: August 2023

We generalize a recent theory of bending of thin micropolar plates by incorporating surface effects through the modeling of plate surfaces as adjacent two-dimensional micropolar elastic bodies. By incorporating both elastic surface effects and the micropolar elastic behavior of the plate, the proposed model is capable of taking into account the contribution of high surface-to-volume ratios as well as the influence of microstructural mechanics at micro/nano scales. We determine the fundamental solution of the resulting system of equations and establish uniqueness results for the corresponding Dirichlet and Neumann boundary value problems. Moreover, we provide a numerical example to demonstrate the efficiency of the model in representing the size-dependence arising from various factors that incorporate characteristic lengths. Furthermore, we showcase the sensitivity of the results to different types of characteristic lengths present in the model.
Political and Psychosocial Antecedents of Self-Rated Successful Aging among Young-Old and Old-Old Adults
Authors: Turska-Kawa Agnieszka , Pilch Irena
Published: August 2023

Due to the demographic growth of older population segments, psychological research is increasingly devoted to the determinants of successful aging. The current study investigates the relationship between older people’s self-perception of aging and its potential political and psychosocial antecedents. We concentrate on a subjective aspect of successful ageing, so we refer to these self-perceptions as self-rated successful ageing. We examine two groups of potential antecedents of self-rated successful ageing associated with political participation (political subjectivity and political agency) and the resources that an individual possesses: personal (a sense of autonomy) and social (perceived social support). Informed by previous research, our study compares two age-separated groups of older people—conveniently labeled the Young-Old (Y-O), aged 65–74, and the Old-Old (O-O), aged 75–95. In line with prior findings, our regressions confirm the importance of autonomy as a positive self-rated successful ageing predictor among the elderly, regardless of whether they fall into the Y-O or O-O group. Political subjectivity, however, turns out to be a significant predictor of self-rated successful ageing only in the Y-O group of the elderly.
Evaluation of the protective effect of losartan in acetaminophen-induced liver and kidney damage in mice
Authors: Şahin Serkan , Aydın Ayça Çakmak , Göçmen Ayşe Yeşim , Kaymak Emin
Published: August 2023

Purpose
Acetaminophen is widely used among humans as an antipyretic and analgesic. In this study, the protective effect of losartan in hepatotoxicity and nephrotoxicity induced by acetaminophen in mice was investigated owing to its anti-inflammatory and antioxidant effects.
Methods
A single dose of 500 mg/kg (i.p.) acetaminophen was injected to induce hepatotoxicity and nephrotoxicity in mice. 1, 3 and 10 mg/kg (i.p.) losartan was injected twice, 1 and 12 hours after the acetaminophen injection. In addition, 4 mg/kg dose of GW9662 (Peroxisome proliferator-activated receptor gamma (PPAR-γ) antagonist) was injected 30 minutes before (i.p.) losartan injections. Samples from animals were collected 24 hours after acetaminophen injection.
Results
Losartan decreased aspartate aminotransferase (AST), alanine aminotransferase (ALT), and increased creatinine levels. Interleukin-1β, -6, -8, -10, -17, tumor necrosis factor (TNF-α) levels were returned to normal by losartan. Losartan, total antioxidant level (TAS), Total oxidant level (TO), Glutathione (GSH), Oxidized glutathione (GSSG), Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx) levels, returned to normal levels. Histopathological changes in liver and kidney tissue were alleviated by losartan. The substance GW9662 increased the protective effect of losartan.
Conclusion
In light of all the data obtained from our study, it can be said that losartan has a protective effect on liver and kidney damage induced by acetaminophen due to its antioxidant and anti-inflammatory effects. In terms of the study, losartan was found to be an alternative substance that could protect people from the harmful effects of acetaminophen.
Electrical interaction between cardiomyocytes and non-myocytes in the metabolic heart contributes to the induction of short QT interval
Authors: Billur Deniz , Olgar Yusuf , Durak Aysegul , Yozgat Ayse Hande , Unay Simge , Tuncay Erkan , Turan Belma
Published: August 2023

Metabolic syndrome (MetS) has impact on arrhythmia pathogenesis includes changes in QT-interval, reflecting time-course of ventricular myocyte action potentials (APs), while long or short QT-interval is associated with ventricular arrhythmias, further leading to sudden-cardiac-arrest. Cardiac conduction-system consists of distinct components besides cardiomyocytes such as non-myocytes and Cx43 via an electrotonic-conduction-coupling. Although there are well-coordination among them under physiological condition, there are important contributions of their changes in remodeling of the heart. To identify molecular mechanisms of SQT development under MetS, we investigated the involvement of non-myocyte-associated passive electrical-contribution in the cardiac remodeling by Cx43 contribution and macrophage coupling with cardiomyocytes. We used an early-state MetS rat model (with high-sucrose for 12–14 weeks), and we evaluated heart samples and freshly isolated ventricular cardiomyocytes by using both electrophysiological and histological investigations. There were significantly high heart rates and SQT in ECGs with a high ventricular contractile response to sympathetic stimulation in the MetS rats. The positive stained α-SMA and CD68 cell numbers were significantly prominent in interfibrillar spaces of hearts, together with prominent increases in expression and longitudinal cell membrane localization of phospho-Cx43. Moreover, there was a significantly shortened AP duration in the papillary muscles, at most, via increases of NaV1.5 density and decreases in L-type Ca2+-channel currents. Considering the electrotonic contribution by non-myocytes to intercellular propagation of APs with changes in phosphorylation and localization of Cx43 in the heart, we, for the first time, demonstrated that electrical-remodeling in early-stage MetS heart may be characterized by a short QT-interval with contributions of electrotonic coupling of excitable cells and non-myocytes, leading to activation of ephaptic-coupling, to be a preconditioning stimulus for development of long QT-interval in chronic MetS.
An RGB Image Encryption Scheme based on Amalgamation of 3D-Dynamical Systems and a Left Almost ring
Authors: Haider Muneeba , Sanam Nazli
Published: August 2023

Digital images are widely used in the areas of medicine, defense, and space technology but their safeguarding and secure transmission is becoming a prevalent issue for researchers and engineers. Image encryption techniques usually make use of commutative and associative algebraic structures like finite Galois fields and unitary commutative rings. In this paper, first, a non-associative LA-ring of order 256 is obtained using computational techniques, and then this LA-ring and the three-dimensional non-linear chaotic Rucklidge system are combined to generate three chaotic-algebraic sequences which are used to cause confusion in encryption. For the sake of diffusion, the three dimensional non-linear chaotic Genesio-Tesi system is utilized. The motivation behind using an LA ring is to boast the robustness and increase the key space due to this algebraic structure's non-associative and non-commutative properties. Furthermore, the number of control parameters has increased because of two, three dimensional chaotic systems which aid in expanding the key space and increase encryption efficiency thus providing better security. Performance metrics are carried out for encrypted images and a comparison with some of the existing chaos dependent schemes is made, proving that the suggested technique approaches the standard prime level and is good enough for encryption processes and real-time communication.
Prognostic aspect of cerebellar hematomas in tropical environments: Study of 33 cases at Conakry University Hospital
Authors: Sory Konaté Ibrahima , Mamady Camara , Camara Mohamed Salifou , M'Bara Souleymane , Doré Malé , Lamine Condé Mohamed , Touré Mohamed Lamine , CIssé Pr Fodé Abass , Cissé Pr Amara
Published: August 2023

Background : Cerebellar hematoma is thought to result from a collection of blood in the cerebellar parenchyma. It is a rare topographical form, accounting for 5-10% of hemorrhagic strokes, with an unpredictable and often dreadful prognosis.
The aim of our study is to determine the prognostic factors of cerebellar hematomas in the Neurology Department of the CHU Ignace Deen in Conakry.
Methodology: We conducted a retrospective descriptive study lasting four (4) years, from June 1, 2017 to May 31, 2021, in the neurology department of the CHU de Conakry, focusing on patients hospitalized with a cerebellar hematoma confirmed by cerebral CT scan. The variables were epidemiological, clinical, therapeutic and prognostic. Any p-value < 0.05 was considered statistically significant.
Results: A total of 33 patients, representing 9.7% of cerebellar hematomas, with a mean age of 60±12.50 years, ranging from 33 to 82 years, and a male predominance of 69.7% (sex ratio 2.3). Hypertension was the main risk factor in 87.9% of cases. The main symptoms were headache in 90.9% of cases, dizziness in 81.8% and vomiting in 60.6%. The factor associated with a favorable outcome was an ICH score≤ 2 (p-value = 0.004)). The mortality rate was 27.3%. A favorable outcome without sequelae was observed in 18.2% of cases, versus 54.6% in cases with neurological sequelae.
Conclusion: At the end of this study, we concluded that cerebellar hematoma constitutes a diagnostic and therapeutic emergency. High ICH and modified Rankin at re-entry were poor prognostic factors associated with functional sequelae and a high mortality rate.
Efficacy of Establishing Physician-Scientists Supporting Program In A Teaching Hospital: A Ten Year Retrospective Study Running title: Efficacy Of Establishing Physician-Scientists Supporting Program In A Teaching Hospital
Authors: Zhang Zikai , Yue Yang , Gong Zhu , Shi Yan , Cai Li , Gao Ping , Gao Yuan , Zhou Yongxin
Published: August 2023

Background
To gain insight into how well the program supports young physician-scientists and offers recommendations to enhance the program’s quality after establishing our hospital supporting physician-scientists program for ten years.
Methods
Take a survey of everyone who participated in the Ganquan Young Star Scholar program at our Hospital between 2011 and 2020. Multiple linear and logistic regression models are used to estimate potential predictive factors to their future success.
Results
52 participants completed the program and 40 responded to the survey. On average, there were 3.55 first & corresponding author publications throughout the program. They received an average of 0.875 external funding during the program and 1.175 within three years after completion. 19 (47.5%) received NSFC funding within three years. They believe supporting visiting scholars in the program is worthwhile as it benefits their future career promotion, external funding applications, and career awards. First & corresponding author publications and receiving external funding during the program are potential predictors of future success.
Conclusions
Our program can help young physician-scientists pursue successful careers. The program is effective, while the mentorship and support for visiting scholar in this program needs improvements in the future.
In silico protein Ligand Docking to study the effect of Astaxanthin and Colchicine against Human Papilloma Virus proteins.
Authors: Das Rajarshi , Santoshi Seneha
Published: August 2023

Human papilloma virus is a deadly virus that causes cervical, penile and vulval cancer. The current effort focuses on HPV's lesser-known proteins, as well as its virulence and prevalence in men and women. The leitmotif of this review is to create drugs against the proteins of the Human papilloma Virus as a suggestive solution against the diseases caused by this virus. The study includes the extraction of the protein sequences of the virus from NCBI, followed with the secondary structure prediction with the aid of the usage of online available protein prediction tools; GOR4, Chou and Fasman and phyre2. Homology modelling using SWISSMODEL was done of each protein (E1, E2, L1 and L2) taken from HPV for receiving the appropriate model for the respective proteins. The PDB files for each of the protein were downloaded and used for docking against respective ligands mentioned in this review. The docking results are elaborately discussed in this study.
Study on the onset mechanism of bio-blister degradation of polyolefin by diatom attachment in seawater
Authors: NAKATANI Hisayuki , NARIZUMI Shun , OKUBO Seiya , MOTOKUCHO Suguru , DAO Anh Thi Ngoc , KIM Hee-Jin , YAGI Mitsuharu , KYOZUKA Yusaku , MIURA Shigenobu , JOSYULA Kanth V.
Published: August 2023

It is essential to develop a mechanism for lowering the molecular weight of polyolefins to achieve biodegradation in seawater. In this study, a prephotodegradation treatment was applied to a blend sample to generate hydroperoxide groups in the polypropylene component of the blend to initiate autoxidation and generate carboxylic acid substances in the poly(lactic acid) component of the blend to promote autoxidation. However, the generated carboxylic acid substances were neutralized in seawater, which is alkaline, disabling the acid-activated autoxidation mechanism for developing biodegradability of the blend. Although aqueous Cl− was an effective inhibitor of autoxidation of polyolefins in seawater, autoxidation could be initiated using the dissociation of ClOH (called blister degradation) to lower the seawater pH. The blister degradation mechanism enabled autoxidation, even in seawater, by taking advantage of the ability of diatoms to secrete transparent exopolymer particles (TEP) to prevent direct contact between the surface layer of polyolefins and alkaline seawater. Bio-blister degradation induced by diatoms was characterized for a linear low-density polyethylene (LLDPE)/starch sample. SEM, IR, and DSC analyses showed that diatoms induced the disintegration of the LLDPE component of the blend sample in seawater.
Graphene oxide structure-oriented NM88B/GO/SA aerogel for highly efficient degradation of dye and antibiotic wastewater
Authors: Lin Xiaoxia , Zhao Jie , Zhang Yongqi , Li Yuqi , Liao Yiqiang , Zhang Hui
Published: August 2023

Photocatalytic water treatment is an advanced and efficient technology for water purification. Among various photocatalysts, iron-based metal-organic frameworks (Fe-MOFs) are widely applied for mineralizing organic wastewater due to their excellent water stability and photocatalytic activity. However, their practical application is impeded by insufficient photocatalytic performance, irreversible collapse of the framework structure during repeated use, and difficulty in recovery. In this study, Graphene oxide (GO) structure-oriented NH2-MIL-88B(Fe)/graphene oxide/sodium alginate (NM88B/GO/SA) aerogel was fabricated for the removal of dyes and antibiotics, using GO interface regulation and dual-network crosslinking methods. In this hybrid system, a NM88B/GO heterostructure was formed through the directional growth of NM88B on the surface of GO. The introduction of sodium alginate (SA) enhanced the robustness and stability of the matrix, and effectively avoided aerogel fragmentation. With 30 wt% catalyst loading, the composite aerogel exhibited excellent photocatalytic degradation performance towards high-concentration (50ppm) tetracycline hydrochloride (TC-HCl), achieving over 99% removal rate in 150 minutes. It also effectively degraded methylene blue (MB) at 10-30ppm with over 99% removal rate. Furthermore, the aerogel showed excellent shape recovery ability, stability, and reusability. After five repeated tests, it maintained over 95% degradation efficiency for both TC-HCl and MB. This advanced aerogel holds great promise as a highly efficient and reusable photocatalyst for removing antibiotics and dyes from wastewater.