bluuebunny/crossref_metadata_2025 huggingface dataset:
The Risk of Hospitalization and Mortality After Breakthrough SARS-CoV-2 Infection by Vaccine Type: Observational Study of Medical Claims Data
Authors: Kshirsagar Meghana , Nasir Md , Mukherjee Sumit , Becker Nicholas , Dodhia Rahul , Weeks William B , Ferres Juan Lavista , Richardson Barbra
Published: October 2022

Background

Several risk factors have been identified for severe COVID-19 disease by the scientific community. In this paper, we focus on understanding the risks for severe COVID-19 infections after vaccination (ie, in breakthrough SARS-CoV-2 infections). Studying these risks by vaccine type, age, sex, comorbidities, and any prior SARS-CoV-2 infection is important to policy makers planning further vaccination efforts.

Objective

We performed a comparative study of the risks of hospitalization (n=1140) and mortality (n=159) in a SARS-CoV-2 positive cohort of 19,815 patients who were all fully vaccinated with the Pfizer, Moderna, or Janssen vaccines.

Methods

We performed Cox regression analysis to calculate the risk factors for developing a severe breakthrough SARS-CoV-2 infection in the study cohort by controlling for vaccine type, age, sex, comorbidities, and a prior SARS-CoV-2 infection.

Results

We found lower hazard ratios for those receiving the Moderna vaccine (P<.001) and Pfizer vaccine (P<.001), with the lowest hazard rates being for Moderna, as compared to those who received the Janssen vaccine, independent of age, sex, comorbidities, vaccine type, and prior SARS-CoV-2 infection. Further, individuals who had a SARS-CoV-2 infection prior to vaccination had some increased protection over and above the protection already provided by the vaccines, from hospitalization (P=.001) and death (P=.04), independent of age, sex, comorbidities, and vaccine type. We found that the top statistically significant risk factors for severe breakthrough SARS-CoV-2 infections were age of >50, male gender, moderate and severe renal failure, severe liver disease, leukemia, chronic lung disease, coagulopathy, and alcohol abuse.

Conclusions

Among individuals who were fully vaccinated, the risk of severe breakthrough SARS-CoV-2 infection was lower for recipients of the Moderna or Pfizer vaccines and higher for recipients of the Janssen vaccine. These results from our analysis at a population level will be helpful to public health policy makers. Our result on the influence of a previous SARS-CoV-2 infection necessitates further research into the impact of multiple exposures on the risk of developing severe COVID-19.
A “Do No Harm” Novel Safety Checklist and Research Approach to Determine Whether to Launch an Artificial Intelligence–Based Medical Technology: Introducing the Biological-Psychological, Economic, and Social (BPES) Framework (Preprint)
Authors: Khan Waqas Ullah , Seto Emily
Published: October 2022

UNSTRUCTURED

Given the impact artificial intelligence (AI)–based medical technologies (hardware devices, software programs, and mobile apps) can have on society, debates regarding the principles behind their development and deployment are emerging. Using the biopsychosocial model applied in psychiatry and other fields of medicine as our foundation, we propose a novel 3-step framework to guide industry developers of AI-based medical tools as well as health care regulatory agencies on how to decide if a product should be launched—a “Go or No-Go” approach. More specifically, our novel framework places stakeholders’ (patients, health care professionals, industry, and government institutions) safety at its core by asking developers to demonstrate the biological-psychological (impact on physical and mental health), economic, and social value of their AI tool before it is launched. We also introduce a novel cost-effective, time-sensitive, and safety-oriented mixed quantitative and qualitative clinical phased trial approach to help industry and government health care regulatory agencies test and deliberate on whether to launch these AI-based medical technologies. To our knowledge, our biological-psychological, economic, and social (BPES) framework and mixed method phased trial approach are the first to place the Hippocratic Oath of “Do No Harm” at the center of developers’, implementers’, regulators’, and users’ mindsets when determining whether an AI-based medical technology is safe to launch. Moreover, as the welfare of AI users and developers becomes a greater concern, our framework’s novel safety feature will allow it to complement existing and future AI reporting guidelines.
Electrochemical Sensor of Levofloxacin on Boron-Doped Diamond Electrode Decorated by Nickel Nanoparticles
Authors: Jiwanti Prastika Krisma , Sitorus Irfansyah Rais , Kadja Grandprix Thomryes Mart , Wafiroh Siti , Einaga Yasuaki
Published: October 2022

Levofloxacin (LEV) was known as one of the fluoroquinolone antibiotics that widely used as an antibacterial agent. Monitoring of LEV is important due to its negative side effect on humans. The determination of LEV was studied for the first time on nickel modified on a boron-doped diamond (NiBDD) electrode using the square wave voltammetry (SWV) method to improve the catalytic and sensitivity of the sensor. The response was linear in the range of 30–100 mM LEV. LEV sensor on NiBDD was found to be selective in the presence of urea, glucose, and ascorbic acid interferences. Good reproducibility with % a relative standard deviation of 1.45% (n = 10) was achieved. Therefore, the NiBDD electrode could be potentially applied for the real detection method of LEV.
Characterization of Lignin Peroxidase from the Suspected Novel Strain Phanerochaete chrysosporium ITB Isolate
Authors: Susanti Evi , Ardyati Tri , Suharjono Suharjono , Aulanni'am Aulanni'am
Published: October 2022

This study was aimed to characterize lignin peroxidase (LiP) obtained from Phanerochaete chrysosporium ITB isolate. The characterizations included molecular weight, the pH and optimum working temperature of the crude extract of the enzyme, the temperature stability, the effect of metal ions and inhibitors, their precipitation with ethanol, and the storage stability. The LiP of P. chrysosporium ITB isolates was 34 kDa. The crude extract of LiP displays high activity at pH between 3 until 5 and 26–32 °C, has good thermal stability at 26–32 °C for 20 h. The activity is affected by Pb2+, K+, Co2+, Fe2+, Cd2+, Mg2+, and Cu2+ EDTA, Na+, Cr3+, Hg2+, NaN3, Ni2+, and Ca2+ ions, is not affected by Mn2+ and Zn2+ ions, precipitated with the optimum ethanol at 64% ethanol saturation which results in an increase in specific activity of 2.3 times. The crude extract storage at 0 °C is more stable than the precipitate resulting from ethanol precipitation and resuspension from ethanol precipitation. These results strengthen that LiP from P. chrysosporium is another LiP isoenzyme that can be used for bioremediation processes. Unfortunately, the concentration using the ethanol precipitation method has not been effective, so further studies using other methods should be required.
Synthesis, Cytotoxicity Evaluation and Molecular Docking Studies of Xanthyl-Cinnamate Derivatives as Potential Anticancer Agents
Authors: Iresha Muthia Rahayu , Jumina Jumina , Pranowo Harno Dwi , Sholikhah Eti Nurwening , Hermawan Faris
Published: October 2022

A new series of xanthyl-cinnamate hybrid compounds (4a-d) have been synthesized and screened through in vitro assay against four human cancer cell lines, i.e., HeLa, T47D, A549, and WiDr. The results revealed that xanthone hybridization with cinnamic acid increases the selectivity of the compounds with SI values of 2.75–209.03 compared to its parent oxygenated-xanthone. Compound 1,3-dihydroxyxanthen-6-yl cinnamate (4c) showed high cytotoxic activity against WiDr cell lines with an IC50 value of 39.57 µM. Molecular docking studies revealed the possible binding modes of all hybrid compounds with EGFR protein. A complex of 3,6-dihydroxyxanthen-1-yl cinnamate (4d)-EGFR, as the best binding model, exhibited higher predicted EGFR inhibitory activity than erlotinib and oxygenated-xanthone with a ΔG and Ki value of -35.02 kJ/mol and 0.74 µM, respectively. Compounds 4c and 4d were chosen as the most potent derivates from the study.
Israeli-Palestinian Conflict Beyond Resolution: A Critical Assessment
Authors: Inas Pratiwi Fadhila , Rasil Syarafi M. Aryo , Nauvarian Demas
Published: October 2022

Of all the inter-state conflict currently happening in different regions of the world, the Israel- Palestine conflict has stood the test of time to become one of the longest and most impactful. Despite numerous attempts to resolve the Israeli-Palestinian conflict, both parties have persisted, mainly showing a lack of compromise and commitment. This paper aims to analyze the underlying reason to the various unsuccessful attempts of Israel-Palestine conflict resolutions. This paper argues that there are four core issues that become object of negotiation in each attempt: borders, security, Jerusalem, and refugees. This paper assesses each party’s stances on these four issues and how they shape the negotiation process. This is done through an empirical generalization by inductive methodology, using library studies as a data collection method. This paper concludes that there should be an ideational change to compromise within the domestic politics of both parties to make future conflict resolution possible.
Study of Organic Constituents in Distillery Spent wash and Primary Treated Distillery Effluent (PTDE) with Different Dilutions
Authors: K N Anusha , M Vagish
Published: October 2022

Abstract: Effluent that is released from distillery industries is known as spent wash which is the main reason for the damaging they caused on the natural ecosystem if there is no proper pre-treatment performed. A proper study is to be performed to detail about the physicochemical property of the effluent such as color, odor, total dissolved solid (TDS), chemical oxygen demand (COD), pH, biochemical oxygen demand (BOD), electrical conductivity, dissolved oxygen which are considered as the important parameters which will indicate the level of pollution of the effluent from different industrial. The present study was conducted to investigate the physicochemical characteristic and organic constituents of one of the distillery effluent found in distillery factory in Duggavati near Harapanahalli (tq) Davanagere . In investigation done by us we observed that the sample is lower pH and highly acidic in nature, higher temperature, higher concentration of chemical oxygen demand (COD) and biochemical oxygen demand (BOD) have been recorded. Disposing of the spent wash is one of the most important and present environmental problems faced by the world. The purpose of the study was to conduct and evaluate the physio-chemical characterization of spent wash effluent and analysis of PTDE and PTDE diluted with 50% and 75% of water.
The Role of Investment Policy in the Innovative Development of Agriculture of the Republic of Uzbekistan
Authors: Sirojiddin Yangiboev
Published: October 2022

Annotation: The article describes the role of agriculture in the national economy of the Republic of Uzbekistan, the socioeconomic results of reforms for its development. The situation with investments in agriculture and the use of investment potential of the agricultural sector was also studied. Scientifically based proposals and practical recommendations on promising areas for attracting investment in the agricultural sector are outlined.
COVID-19 pandemic as a catalyst of art workers mobilisation and unionisation: the case of Greek actors
Authors: Karakioulafi Christina
Published: October 2022

In Greece, as in other countries, the cultural sector is among the most affected by the coronavirus crisis, bringing to the surface structural problems that these sectors have been facing. As the first Greek state’s first support measures were ill-adapted to cultural sectors’ forms of employment, artists’ unions mobilised and new solidarity groups and campaigns such as Support Art Workers (SAW) emerged. Based on findings deriving from qualitative research, the article examines the impact of the coronavirus crisis on the employment conditions and livelihood opportunities of actors/actresses in Greece; their mobilisations during the same period. Findings show that despite the constraints imposed through containment and social-distancing measures, the enforced inactivity and the exposure of vulnerability incited collective discussions and triggered collective processes, due to fewer time constraints, but mainly because of the actors' own awareness of the precariousness of their working conditions.
Problemas socio-existenciales derivados del alargamiento de la juventud en un contexto de precariedad
Authors: Dueñas Rello Erik
Published: October 2022

En el presente artículo se revisa el alargamiento de la juventud que afrontan numerosos jóvenes en la actualidad, para comprender cómo entienden los jóvenes españoles las diferentes problemáticas derivadas de ella, y sus consecuencias socio-existenciales. Se parte del análisis de diecinueve entrevistas y tres grupos de discusión realizadas durante 2018 y 2019 a jóvenes españoles de entre 25 y 35 años en situación de precariedad. Los resultados apuntan a una comprensión generalizada de los problemas sociales desde una óptica de la individualización, junto a una normalización de la precariedad laboral en sus narraciones. Se profundiza en el presentismo desplegado ante el sentimiento de estar atrapados en presentes intransitables. Se analizan cómo las biografías de los jóvenes experimentan desfases temporales debido a sus dificultades para dar respuesta a los eventos transicionales. Por último, se incide en el papel de los soportes como amortiguadores cotidianos de los problemas de la precariedad.
La participación juvenil en entornos urbanos: trayectorias e inquietudes asociativas. Estudio de caso del distrito de Sant Martí de Barcelona
Authors: Martín-Gómez Albert
Published: October 2022

Este artículo presenta una aproximación cualitativa a las trayectorias e inquietudes que mueven a la juventud a participar y asociarse en entornos urbanos. Las políticas de promoción de la participación juvenil han acostumbrado a desarrollarse sin tener en cuenta la diversidad de inquietudes políticas y sociales de la juventud ni el contexto asociativo del entorno. El estudio de caso del distrito de Sant Martí de Barcelona, y concretamente de su contexto asociativo en el periodo 2011-2019, permite identificar cuatro tipologías de colectivos juveniles en función de sus inquietudes y edades: grupos informales, asociaciones con proyecto comunitario, plataformas reivindicativas y coordinadoras de entidades. Estas tipologías se distinguen por los márgenes de edad de los jóvenes y por sus inquietudes grupales más “finalistas” o más “instrumentales” en función de la edad. Estos resultados permiten comprender las trayectorias de articulación del asociacionismo y su relación con las instituciones públicas.
Efeito escola a partir de indicadores educacionais: análise entre escolas públicas e privadas no ENEM
Authors: Moraes Caroline Ponce de , Peres Rodrigo Tosta , Barbosa Tereza Serrano , Pedreira Carlos Eduardo
Published: October 2022

Neste artigo analisou-se a relação entre os indicadores educacionais e o desempenho em matemática de alunos de escolas públicas e privadas no Exame Nacional do Ensino Médio. Utilizou-se uma modelagem multinível com indicadores no nível da escola, a fim de medir o efeito no desempenho, além de fazer comparações descritivas por dependência administrativa. Os modelos ajustados foram controlados por variáveis da família e individuais no nível aluno. Encontrou-se que o efeito escola foi de 13% para as escolas privadas e 9% para as públicas, o que indica que os fatores que independem das ações pedagógicas e de gestão da escola têm uma grande contribuição no desempenho, tanto para os estudantes de escolas privadas quanto os de escolas públicas.
Relação da qualificação docente na esfera acadêmica, profissional e pedagógica com o conceito preliminar do curso em Ciências Contábeis
Authors: Oliveira Joice Marques Garra de , Bianchi Márcia , Engel Cristina Inês , Venturini Lauren Dal Bem
Published: October 2022

O objetivo do estudo é analisar a relação, com base na percepção do educador, da qualificação docente na esfera acadêmica, profissional e pedagógica com o Conceito Preliminar do Curso (CPC) em Ciências Contábeis na modalidade presencial. Aplicou-se questionário aos docentes obtendo 194 respondentes, sendo realizada análise descritiva, com a utilização de estatística descritiva e regressão linear múltipla. Cursos com maior CPC apresentam maior percentual de docentes com altas titulações, mas professores de CPC baixo apreciam mais a qualificação acadêmica. No âmbito profissional, a experiência de mercado é maior que dez anos em todos os CPCs. Na esfera pedagógica, o tempo de docência é maior nos CPCs altos e esses se associam ao índice de qualidade do ensino superior - Conceito ENADE. Assim, contribui-se na análise do quadro docente e de possíveis melhorias e investimentos em qualificação dos mesmos.
Iranian EFL Learners’ Perceptions towards Demotivation in Learning English
Authors: Paziresh Abbas , Hessamodini Nilofar , Jafari Zohre
Published: October 2022

Demotivation in learning English has always been challenging for teachers, parents and researchers and they sought ways to discover its roots and solve it. One important source of solutions to learners’ demotivation is their own perceptions. However, such a rich resource of information on demotivation has received little attention. Therefore, inspired by such a gap, the present study investigated Iranian high school EFL students’ perceptions of demotivation in learning English. Following quantitative survey research, a questionnaire was designed both inspired by demotivation questionnaires of Sakai and Kikuchi (2009) and Falout and Maruyama (2004) and teachers’ focus group on attitudes. It was created based on the Likert Scale and composed of three phases including 54 statements about teachers, textbooks and classroom conditions. The questionnaire was sent to 300 volunteer high school students selected from a random list of public and private high schools across the country. After completion, the questionnaire data were controlled and entered into SPSS. Then, descriptive statistics were computed and Pearson correlation and Runs Test were carried out. However, analysis of the learners’ perceptions revealed that students attributed their demotivation to teachers, classroom conditions, and textbooks respectively. It was found that in Iran, teachers were deemed not qualified enough to motivate students. Apart from that, the classroom conditions and English textbooks were in poor conditions and did not manage to attract and motivate learners.
La educación ambiental: interés prioritario de Mario Boza en su quehacer. Algunas experiencias pioneras de capacitación
Authors: María Eugenia Zúñiga Chaves
Published: October 2022

Desde los inicios de la década de los 70, cuando se organizaban diversos eventos internacionales que destacaban la importancia de la educación para lograr el mejoramiento del ambiente y la conservación de los recursos naturales; en Costa Rica se crean instituciones que ofrecen oportunidad de brindar capacitación en educación ambiental a diversos sectores de la población. Para que esto fuera posible don Mario Boza jugó un papel importantísimo como fundador de la Escuela de Ciencias Ambientales en la UNA, del Programa de Educación Ambiental en la UNED y del Programa de Educación Ambiental en el MINAE. En estas instituciones se gestaron diversos cursos de capacitación teniendo claro el efecto multiplicador que las poblaciones meta tendrían en crear conciencia de la importancia de la conservación, el manejo sostenible de los recursos y la búsqueda de soluciones a los problemas ambientales de su comunidad. El artículo expone algunas experiencias de enseñanza que en los años 70 fueron pioneras y que tuvieron gran impacto en el país en las dos décadas posteriores. Se indica a su vez las diferentes poblaciones meta y las distintas modalidades utilizadas.
Immunosuppressive Effect of Methanol Extract and Ethyl Acetate Fraction of Breadfruit [Artocarpus altilis (Park.) Fosberg] Leaves
Authors: Palupi Dwi Hadi Setya , Soemardji Andreanus A. , Iwo Maria Immaculata
Published: October 2022

Background: Artocarpus sp. contained a variety of flavonoids, some of which have been shown to reduce inflammation. In vitro anti-inflammatory activity of breadfruit (Artocarpus altilis (Park.) Fosberg) has been demonstrated. Chronic inflammation can occur when immune defence mechanisms are activated by inflammatory conditions. Objectives: This study examined breadfruit leaf methanol extract and ethyl acetate fraction immunosuppressive effects. Material and Methods: The bioactive compounds in breadfruit leaves were extracted in methanol via maceration and fractionation in ethyl acetate via liquid-liquid extraction. The in vivo immunosuppressive effect was evaluated in male Swiss albino mice by humoral antibody titer, delayed-type hypersensitivity, and phagocytic index assays. Results: According to phytochemical screening, flavonoids and steroids were found in the extract and its ethyl acetate fraction. The breadfruit leaf extract and fraction showed an immunosuppressive effect through phagocytic index<1, and the thymus gland index was significantly decreased (p<0.05) compared to control. The breadfruit leaf extract and the ethyl acetate fraction were able to inhibit the production of antibodies and DTH reactions, two types of immune responses. Conclusions: The extract of breadfruit leaves and the ethyl acetate fraction showed immunosuppressive properties.
Endometrial cancer ProMisE classification predicts the risk of lymph node metastasis and prognosis
Authors: Li Qian , Zhang Xin
Published: October 2022

Objective:To assess the correlation between ProMisE classification and
lymph node metastasis(LNM) of endometrial carcinoma(EC). Design:A
retrospective cohort study. Setting:Department of gynecologic oncology
at Liaoning Cancer Hospital in China. Population:From January 1st,2014
to December 31st, 2018,a total of 74 women with EC were included.32
cases had pelvic or para-aortic LNM and 42 cases had no LNM. Methods:The
formalin-fixed paraffin-embedded(FFPE) tissue sections of EC patients
were analyzed by the Proactive Molecular Risk Classifier
for Endometrial cancer (ProMisE) classification,and to evaluate the
correlation between ProMisE classification and LNM and prognosis of the
patients receiving different postoperative adjuvant therapies. Main
outcome measure:Correlation between ProMisE classification and
LNM,Overall Survival(OS) and progression-free survival(PFS). Results: In
the ProMisE classification,mismatch repair deficient(MMRd) was linked to
low pathological grade (p value=0.006; correlation=-0.315), p53 abnormal
subtype(p53abn) was correlated with LNM (p value=0.0004;
correlation=-0.472) and late International Federation of Gynecology and
Obstetrics (FIGO) stage (p value=0.005; correlation=-0.386).The 5-year
overall survival was 100% in Polymerase Epsilon exonuclease domain
mutated(POLE EDM), 85% in MMRd, 91.2% in p53 wild-type(p53wt) and
83.3% in p53abn.The 5-year PFS was 100% in POLE EDM, 95% in MMRd,
94.1% in p53wt and 77.8% in p53abn.We also found no statistical
difference in patients‘ benefits from Radiotherapy(RT) alone and
concurrent chemoradiotherapy(CCRT) in different molecular
subtypes,however,the patients had a trend toward benefit from CCRT in
the p53abn subtype. Conclusions:ProMisE classification can predict the
risk of LNM,histological grade,clinical staging and prognosis, which is
expected to guide the postoperative adjuvant treatment of EC patients.
Effects of different ovarian stimulation protocols on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in patients with adenomyosis: a retrospective cohort study
Authors: Ge Li , Li Yexing , Cui Lin , Chen Zi-Jiang
Published: October 2022

Objective: to evaluate effects of different ovarian stimulation
protocols on in vitro fertilization(IVF) or intracytoplasmic sperm
injection (ICSI) outcomes in infertile women with adenomyosis. Design: A
retrospective, cohort study Setting: Tertiary referral hospital
Population: A total of 562 cycles were included in the study with 257
cycles of fresh ET and 305 cycles of FET in patients with adenomyosis.
Methods: According to ovarian stimulation protocol in fresh ET and
embryo origin in FET, ultra-long, long, short and antagonist subgroups
were divided. Main Outcomes Measure(s)：clinical pregnancy rate (CPR),
implantation rate(IR), miscarriage rate (MR) and live birth rate (LBR).
Results：Compared with ultra-long and long protocols, IR (28.2% versus
49.7%, 52.1%, P=0.001) and CPR (35.6% versus 64.3%, 57.4%, P=0.004)
in short protocol significantly decreased. Similarly, a decreased
inclination of IR (33.3% versus 49.7%, 52.1%) and CPR (38.2% versus
57.4%, 64.3%) existed in antagonist protocol, although no statistical
significance was detected because of strict P adjustment of Bonferroni
method (Padj=0.008). Compared with long protocol, LBR in short protocol
decreased obviously (48.2% versus 20.3%, P<0.001). LBR in
antagonist protocol was also similarly poor (39.8% versus 26.5% and
20.3%). In FET cycles, no matter which origin of embryo, IR, CPR and
LBR had no statistical difference. Conclusions：In fresh ET cycles,
ultra-long or long protocol could be appropriate choices. whole embryo
frozen combined with FET might recover the poor outcomes of antagonist
and short protocols in fresh ET. embryo origin had no impact on
pregnancy outcomes in FET cycles.
Phenotypic divergence in an island bee population: Applying geometric morphometrics to discriminate population-level variation in wing venation
Authors: Ostwald Madeleine , Thrift Charles , Seltmann Katja
Published: October 2022

Phenotypic divergence is an important consequence of restricted gene
flow in insular populations. This divergence can be challenging to
detect when it occurs through subtle shifts in morphological traits,
particularly in traits with complex geometries, like insect wing
venation. Here, we employed geometric morphometrics to assess the extent
of variation in wing venation patterns across reproductively isolated
populations of the social sweat bee, Halictus tripartitus. We examined
wing morphology of specimens sampled from a reproductively isolated
population of H. tripartitus on Santa Cruz Island (Channel Islands,
Southern California). Our analysis revealed significant differentiation
in wing venation in this island population relative to conspecific
mainland populations. We additionally found that this population-level
variation was less pronounced than the species-level variation in wing
venation among three sympatric congeners native to the region, Halictus
tripartitus, Halictus ligatus, and Halictus farinosus. Together, these
results provide evidence for subtle phenotypic divergence in an island
bee population. More broadly, these results emphasize the utility and
potential of wing morphometrics for large-scale assessment of insect
population structure.
Gastric ischemia and pulmonary embolism in a patient with acute leukemia
Authors: Bizid Sondes , Farhat Fatma Ben , Arous Younes , Bennaser Sonia
Published: October 2022

A Tunisian male diagnosed with an acute lymphoblastic leukemia was
admitted to our hospital for a chemotherapy cure . During the
hospitalization, he presented an acute epigastric pain with fever.
Abdominal CT scan showed circumferential gastric thickening with an
enhancement defect suggestive of gastric ischemia associated with
segmental pulmonary embolism.
Highly sensitive strain sensor based on microfiber coupler for wearable photonics healthcare
Authors: Gan Jiulin , Wang Xin , Zhou Hongyou , Chen Meihua , He Yongcheng , Zhang Zhishen , Yang Zhongmin
Published: October 2022

High sensitivity flexible strain sensors that can perceive and respond
to strain stimulation are an essential part of wearable smart devices.
Yet, the detection of subtle strains on the human body and external
stimulation suffers from low sensitivity and slow response of many
existing sensors. Here, an ultrasensitive flexible optical sensor based
on microfiber coupler encapsulated by Polydimethylsiloxane (PDMS) has
been proposed to realize weak strain detection and fast response.
Benefiting from dramatic change of coupling ratio (CR) of the microfiber
coupler under weak strain, this flexible strain sensor exhibits
ultrahigh strain sensitivity (gauge factor, GF=900), low detection limit
of 0.001%, ultrafast response time (< 0.167 ms), and superior
durability and stability (>10 000 cycles). Synchronously,
the simultaneous detection of CR and loss parameters not only realizes
the 0.001% low detection limit, but also expands the sensing range to
0.45%. This highly sensitive microfiber coupler sensor has been
demonstrated to capture and recognize respiration, broadband sound
signals and pulse waves at different sites of human body in real time.
Moreover, based on frequency division multiplexing technology, the wrist
pulse and human voice could be detected and demodulated simultaneously.
This flexible photonics strain sensor could be useful in the development
of convenient and wearable healthcare devices.

Corresponding author(s) Email: 
msgan@scut.edu.cn；zhangzs@fosu.edu.cn;
Interleukin-1β, interleukin-6 and interleukin-10 polymorphisms in Tunisian patients with colorectal cancer and liver metastasis
Authors: Hazgui Meriam , Weslati Marwa , Ounissi Donia , Boughriba Rahma , Bacha Dhouha , Loueslati Basma
Published: October 2022

The balance between pro- and anti-inflammatory cytokine expression is essential for an efficient immune response and for the regulation of cancer development and progression. This study analyzed the expression and genetic variation in IL-1?, IL-6 and IL-10 genes and the possible associations with colorectal cancer (CRC) and colorectal liver metastases (CRLM). We examined IL-1?, IL-6 and IL-10 mRNA expression and three gene variants: IL-1? (rs1143627), IL-10 (rs1800872) and IL-6 (rs1800795), in 198 CRC, 65 CRLM patients and 230 controls. Carriers of the C/T genotype of IL-1? (rs1143627) have an increased risk of developing CRC and CRLM. T/T genotype carriers have a higher risk of CRLM incidence. For IL-10 (rs1800872), patients harboring the C/A genotype have a lower risk of CRC and CRLM occurrence. For IL-6 (rs1800795), the C/C genotype heightens the risk of CRLM development. Overall survival analysis showed that carriers of the C/T genotype of IL-1? (rs1143627) have a worse overall survival in CRC patients. It can be concluded that interleukin genetic variants can be used as biomarkers to detect and predict clinical outcomes and prognostic factors for CRC and CRLM.
Study on mechanisms of microwave synthesis of SiC crystal from sheet carbon source
Authors: Song Bozhen , Dong Chenjiang , Zhang Xinyue , Fan Bingbing , Gao Jingqing , Zhang Rui
Published: October 2022

Needle-like SiC whiskers were synthesised by microwave heating using graphite
sheets and tetraethoxysilane (TEOS) as raw materials. It was found that SiC
powder could be synthesised at 1000?C for 10min, lower than that of samples
made from a granular C source. Furthermore, the heating rate of the samples
made with graphite sheets was higher than that of a granular C source. The
main morphology of the SiC whiskers was needle-like, which appeared when
samples were heated at 1200?C for 10min. Size of the SiC whiskers made with
graphite sheets was more uniform than that of a granular C source, which was
attributed to the 2D thermal effect. Moreover, the size and the amount of
the SiC whiskers increased as the heating temperature increased from 1200 to
1400?C for 10min. The SiC whiskers were oxidised and decomposed into SiC
particles when heated to 1500?C for 10min and only SiC particles existed
when longer holding times were used.
Synthesis, characterization and photocatalytic efficiency of Fe3O4/SiO2/TiO2, SrFe12O19/SiO2/TiO2 and Fe3O4/SiO2/ZnO core/shell/shell nanostructures
Authors: Bavarsiha Fatemeh , Dadashian Saeideh , Montazeri-Pour Mehdi , Ghasemy-Piranloo Fardin , Rajabi Masoud
Published: October 2022

In this research, three magnetically separable photocatalysts, Fe3O4/SiO2/TiO2, SrFe12O19/SiO2/TiO2 and Fe3O4/SiO2/ZnO, with core/shell/shell structures were successfully prepared. In the first step, soft magnetic and hard magnetic Fe3O4 and SrFe12O19 powders were synthesized using carbon reduction and co-precipitation routes, respectively. In the second step, silica coating was performed by controlling the hydrolysis and con- densation of tetraethyl orthosilicate (TEOS) precursor on the magnetic cores. In the third step, a layer of TiO2 or ZnO photocatalytic shells was made on the as-prepared composites using titanium n-butoxide (TNBT) or zinc nitrate hexahydrate, respectively. The formation of the core/shell/shell structures was confirmed by FESEM and TEM analyses. The saturation magnetizations of the Fe3O4/SiO2/TiO2, SrFe12O19/SiO2/TiO2 and Fe3O4/SiO2/ZnO photocatalytic materials were 41.5, 33 and 49 emu/g, respectively. Photocatalytic activity was evaluated by degradation percentages of methylene blue (MB) under UV illumination, which were 88%, 83% and 62%, for the Fe3O4/SiO2/TiO2, SrFe12O19//TiO2 and Fe3O4/SiO2/ZnO composites, respectively. The first-, and second-order reaction kinetics were used to find out the suitable MB removal kinetics.
Endothelial-Specific Expression of CIDEC Improves High-Fat Diet–Induced Vascular and Metabolic Dysfunction
Authors: Balakrishnan Bijinu , Gupta Abhishek , Basri Rabia , Sharma Vishva M. , Slayton Mark , Gentner Kailey , Becker Chloe C. , Karki Shakun , Muturi Harrison , Najjar Sonia M. , Loria Analia S. , Gokce Noyan , Puri Vishwajeet
Published: October 2022

Cell death-inducing DNA fragmentation factor-α–like effector C (CIDEC), originally identified to be a lipid droplet–associated protein in adipocytes, positively associates with insulin sensitivity. Recently, we discovered that it is expressed abundantly in human endothelial cells and regulates vascular function. The current study was designed to characterize the physiological effects and molecular actions of endothelial CIDEC in the control of vascular phenotype and whole-body glucose homeostasis. To achieve this, we generated a humanized mouse model expressing endothelial-specific human CIDEC (E-CIDECtg). E-CIDECtg mice exhibited protection against high-fat diet–induced glucose intolerance, insulin resistance, and dyslipidemia. Moreover, these mice displayed improved insulin signaling and endothelial nitric oxide synthase activation, enhanced endothelium-dependent vascular relaxation, and improved vascularization of adipose tissue, skeletal muscle, and heart. Mechanistically, we identified a novel interplay of CIDEC–vascular endothelial growth factor A (VEGFA)–vascular endothelial growth factor receptor 2 (VEGFR2) that reduced VEGFA and VEGFR2 degradation, thereby increasing VEGFR2 activation. Overall, our results demonstrate a protective role of endothelial CIDEC against obesity-induced metabolic and vascular dysfunction, in part, by modulation of VEGF signaling. These data suggest that CIDEC may be investigated as a potential future therapeutic target for mitigating obesity-related cardiometabolic disease.
2000’li yıllarda Türkiye’de Emek Piyasasında Gelişmeler: Karşılaştırmalı Bir Analiz
Authors: Çiçen Yıldırım Beyazıt
Published: October 2022

Bu çalışmanın temel amacı 2008 küresel krizi öncesi ve sonrasında Türkiye emek piyasasında oluşan değişimleri ve refah kayıplarını analitik yöntemler kullanarak incelemektir. Çalışmada öncelikle 1990’lı ve 2000’li yıllarda Türkiye ve Dünya’da işsizliğin seyri ele alınmıştır. Görülmektedir ki, Türkiye’nin işsizlik oranı ortalaması dünya ortalamasının üzerinde artmıştır. İkinci ana başlıkta küresel krizde Türkiye’nin emek piyasası incelenmiştir. Burada eğitim, kent-kır ve tarım dışı işsizlik konuları ele alınmıştır. Tarım dışı işsizlik oranları Hodrick-Prescott filtresi kullanılarak analiz edilmiştir. Buna göre ülkemizde küresel kriz, işsizliği yaklaşık 4 puan artırmıştır ve işsizlik serisi asimetriktir. Ayrıca kriz ve toparlanma döneminde erkek ve kadınlar farklı dinamiklere sahiptir. Devamında Türkiye istihdam piyasasındaki değişimler incelenmiştir. İstihdam önce sektörel bazlı olarak değerlendirilmiş, tarım ve hizmetler sektörleri arasındaki geçişlilik ortaya konulmuştur. Diğer alt başlıklarda küresel krizin istihdama etkileri işteki durum, eğitim ve cinsiyet üzerinden incelenmiştir. Dördüncü ana başlıkta Türkiye’de krizlerde kazançların seyri işteki durum ile cinsiyet ve eğitim açısından incelenmiştir. Son olarak Türkiye ve Avrupa Birliği ülkelerinin emek ekonomisi performansı karşılaştırmalı olarak analiz edilmiştir. İlk alt başlıkta ücretler ve maliyetlerin seyri analiz edilmiştir. Türkiye’nin küresel kriz öncesi ve sonrasında birim işgücü maliyetleri diğer ülkelerden yüksektir. Diğer bir konu kayıt dışı istihdamdır. Türkiye kayıt dışı istihdam oranlarını azaltmasına rağmen, hâlen Avrupa ülkelerinin üzerinde bir orana sahiptir.
Finansal Stres Endeksinin Dalgacık Dönüşümlü Yapay Sinir Ağları Kullanılarak Tahmin Edilmesi
Authors: Sarı Salim Sercan
Published: October 2022

Finansal risk ve belirsizlikler nedeniyle karşılaşılan problemler dikkate alındığında, finansal stres endeksinin belirlenmesi büyük önem taşımaktadır. Çalışma ile makine öğrenmesi yöntemleri kullanılarak finansal stres endeksi seviyesinin tahmin edilmesi amaçlanmaktadır. Bu amaçla finansal stres endeksinin haftalık zaman serileri, bağımsız ve hibrit modeller kullanılarak incelenmiştir. Yapay sinir ağları, bağımsız makine öğrenme modelleri olarak kullanılırken, hibrit modeller oluşturmak için bir ön işleme tekniği olarak dalgacık dönüşümü kullanılmıştır. Ayrıca, finansal stres endeksi tahminlerinde, model doğruluklarını artırmak için otokorelasyon fonksiyonlarını kullanarak gecikme uzunlukları elde edilmiştir. Çalışmanın bulguları, çeşitli performans göstergeleri açısından değerlendirilmiştir. Finansal stres endeksinin tahmin edilmesinde dalgacık dönüşümlü yapay sinir ağları modelinin, yalın yapay sinir ağları modelinden daha iyi performans sergilediği tespit edilmiştir. Çalışma sonuçlarının finansal stres endeksini takip eden araştırmacı ve uygulayıcılar için fayda sağlayacağı düşünülmektedir.
Üniversitede Görev Yapan Akademik ve İdari Personelin Spora Yönelik Tutumlarının İncelenmesi
Authors: Bektaş Merve , Demir Okan
Published: October 2022

Çalışmada üniversite ortamında, farklı çalışma alanlarında bulunan idari personelin ve akademik personelin spora yönelik tutumlarının, psikososyal, fiziksel zihinsel gelişim alanları bağlamında incelenmesi amaçlanmıştır. Araştırmanın evrenini üniversitelerde görev yapan akademik ve idari personel, örneklem grubu ise bu kurumlarda aktif çalışan ve basit rastgele yöntemine uygun olarak iletişim kurulan 45 akademisyen ve 55 idari personel olmak üzere toplam 100 katılımcı oluşturmuştur. Katılımcılara Koçak (2014) tarafından geliştirilen ʻʻSpora Yönelik Tutum Ölçeği ʼʼ uygulanmıştır. Ölçek 22 maddeden ve 3 alt boyuttan meydana gelmiştir. Değişkenlere Kolmogorov Smirnov testi uygulanmıştır. Yapılan test sonucunda elde edilen değişkenlerin varyanslarının normal dağılım göstermediği saptanmıştır. Ölçek alt boyutları ile demografik bilgiler arasındaki analiz Mann Whitney U testi ile gerçekleştirilmiştir. Analiz %95 güven aralığı içerisinde p
Pelatihan Online Psikologi Positif Berbasis Nilai Islam untuk Meningkatkan Resiliensi Mahasiswa
Authors: Hapsari Dian Kusuma , Karyani Usmi , Hertinjung Wisnu
Published: October 2022

Abstract. University students are vulnerable to psychological problems, including Muslim university students. One of the reasons is the low resilience level. Therefore, an intervention is needed to develop the resilience of Muslim students so that it is expected to face difficulties and at the same time encourage self-development to protect students from psychological problems. The intervention will be better if it is adjusted to the values held by students, one of which is religious values. However, psychological interventions based on religious values to increase student resilience have not been developed much. This study aims to examine the effect of Islamic-based positive psychology online training on the improvement of university students’ resilience. The training modules were prepared based on the positive psychology intervention techniques and integrated with Islamic values. The training consists of six sessions and was delivered via Zoom meeting. This study employed a quasi-experiment with a one-group design pretest-posttest. The target participants of this study were Muslims students of the Universitas Muhammadiyah Surakarta. Participants who took part in this study received information that was announced through several social media. The study participants were 10 Universitas Muhammadiyah Surakarta students. The Connor-Davidson Resilience Scale (CD-RISC) was used to measure the resilience in Universitas Muhammadiyah Surakarta’s students. The data were analyzed using repeated-measures ANOVA and the results showed the scores of p = 0.005 (p 0.05). This result showed that online positive psychological training with Islamic values improves the university students’ resilience. Online positive psychology training based on Islamic can be used for promotive programs to improve Muslim students' mental health in Indonesia.Keywords: Islamic values; online training; positive psychology; resilience; university students
Factors mediating work-family balance to job satisfaction in higher education during pandemic
Authors: Made Rai Ni Gusti , Ratu Aurelius , Savitri Eka Dian
Published: October 2022

Abstract. The covid-19 pandemic has had an impact on the family and work domains and has forced married employees to adapt to the new condition and strive to achieve the workplace’s established goals. However, given the health risk involved in this situation, can they be satisfied with their job? This question arose because some studies showed that flexibility and more incentive payments were considered to support job commitment, and therefore job satisfaction. Thus, our main concern is whether job satisfaction can becompensated solely through incentive payment, which is economics. Although job satisfaction is intended to measure the quality of employment, those studies presumably amplified the imbalance between work and family relationships. This current study investigates job satisfaction for married employees by highlighting the family domain and exploring the intervening factors that play significant roles during the pandemic.The results of multiple regression analysis of 264 married employees of (with sig 0.1 or 0.05) and path analysis bring our attention to work aspects that appear to be more worrisome than family concerns. As an effort to monitor the quality of employment, it will be ambiguous if, for the sake of job satisfaction, the organization have to pay more incentive payment for increasing commitment without paying more attention to a broader context of the situation. Practical policy implications of the findings of this study are also discussed.Keywords: family balance; job satisfaction; married employee; work balance
A Bibliometric Analysis of Zakat Literature from 1964 to 2021
Authors: Supriani Indri , Iswati Sri , Bella Firsty Izzata , Tumewang Yunice Karina
Published: October 2022

This research is intended to provide a comprehensive historical and present development of zakat literature through bibliometrics analysis extracted from Scopus database. From 522 articles related to zakat, the findings show that Universiti Utara Malaysia, IMEFM, and Saad, R. A. J have become the most institution, journal and author that published in zakah literature respectively. Moreover, the article from Haniffa, R; Hudaib (2007) is found to be the most cited article worldwide. While Malaysia has become the hub center of the research collaboration network with a strong collaboration with Indonesian researchers.
PERCEPÇÕES SOBRE CLASSIFICAÇÃO DOS SERES VIVOS ENTRE ESTUDANTES DO ENSINO MÉDIO EM UMA ESCOLA DA REGIÃO SISALEIRA, BAHIA
Authors: Nascimento Cerqueira Erik José , Conceição Veloso-Junior Vanderlei da , Souza Santos Elenir
Published: October 2022

No ensino de Biologia é comum se observar desconhecimento em relação a diversidade de seres vivos, as diferenças entre eles e sua própria classificação. Neste sentido, objetivou-se identificar as concepções de estudantes sobre a diversidade e classificação dos seres vivos e os processos de ensino e aprendizagem, interligando a prática pedagógica com o cotidiano dos estudantes. A pesquisa possui abordagem qualitativa, através da aplicação de questionários para 65 estudantes do ensino médio, da região sisaleira da Bahia. A Análise Textual Discursiva foi utilizada para a análise dos dados. Os Animais e as Plantas foram os grupos mais recordados pelos estudantes. Os animais domésticos foram citados como pertencentes ao bioma Caatinga, evidenciando dificuldades em identificar as espécies nativas do bioma. Assim, propõem-se a necessidade de trazer à tona práticas educativas sobre os seres vivos da própria região e bioma, por vezes esquecidos, relacionando-os com os esforços pela conservação.
Hazards of riverbed processes in Russian rivers: Evaluation criteria, mapping and regional analysis
Authors: Chalov Roman S. , Chernov Alexey V. , Mikhailova Nadezhda M.
Published: October 2022

The danger of riverbed processes is considered. Their speed varies from the first few months of the flood to the most dynamic process in nature. It happened in front of people. This may make life on the river bank and the utilization of river resources more difficult. This paper introduces the causes and consequences of the danger performance of riverbed processes, and focuses on the mapping methods of the danger assessment of riverbed processes: determining the danger degree of riverbed processes and different methods of displaying it on the map. An example of displaying danger on the previously drawn map is given, and the distribution of different types and expression degrees of dangerous riverbed processes under various natural conditions in Russia is briefly analyzed.
Relaxin inhibits 177Lu-EDTMP associated cell death in osteosarcoma cells through notch-1 pathway
Authors: Xu Junhua , Wan Song , Chen Wei , Zhang Yi , Ji Zhenzhong
Published: October 2022

177Lu-EDTMP (Ethylenediamine tetramethylene phosphonic acid) is the most used radioactive agent for pain palliation in bone cancer patients. The present study aims to study the impact of relaxin-2 on the 177Lu-EDTMP associated cell toxicity and death in osteosarcoma cells. MG63 and Saos-2 cells were cultured with 177Lu-EDTMP (37 MBq) for 24 h with and without pretreatment of recombinant relaxin 2 (RLXH2) for 12 and 24 h. 177Lu-EDTMP associated cellular deterioration and death was determined by LDH, MTT, and trypan blue dye assays. ELISA-based kit was used to determine apoptotic DNA fragmentation. Western blotting was used to determine expression levels of apoptotic-related signalling pathway proteins like bcl2, poly(ADP-ribose) polymerase (PARP), and MAPK (mitogen-activated protein kinase). Our results found that RLXH2 counters 177Lu-EDTMP associated cellular toxicity. Similarly, RLXH2 was able to counter 177Lu-EDTMP induced cell death in a concentration and time--dependent manner. Furthermore, it was found that RLXH2 treatment prevents apoptosis in 177Lu-EDTMP challenged cells through activation of the notch-1 pathway in a concentration- and time-dependent manner. We reported that RLXH2 significantly declined cellular toxicity and apoptosis associated with 177Lu-EDTMP in MG63 and Saos-2 cells through the notch-1 pathway.