bluuebunny/crossref_metadata_2025 huggingface dataset:
Anakinra versus Baricitinib: Different Strategies for Patients Hospitalized with COVID-19
Authors: García-García José A , Pérez-Quintana Marta , Ramos-Giráldez Consuelo , Cebrián-González Isabel , Martín-Ponce María L , del Valle-Villagrán José , Navarro-Puerto María A , Sánchez-Villegas Jorge , Gómez-Herreros Rocío , Manoja-Bustos Isabel , León-Martí Daniel , Serrano-Rodríguez Lucía , de Miguel-Albarreal Alejandra , Velasco-Romero María J , Mula-Falcón Francisco , Fernández-Pérez Pilar , Melguizo-Moya Isabel , Pérez-Quintana María J , Romero-Molina Guillermo , Vergara-López Salvador , Marenco-de la Fuente José L , Marín-Martín Jorge , Mira-Escarti José A
Published: September 2021

Background: Immunomodulatory drugs have been used in patients with severe COVID-19. The objective of this study was to evaluate the effects of two different strategies, based either on an interleukin-1 inhibitor, anakinra, or on a JAK inhibitor, such as baricitinib, on the survival of patients hospitalized with COVID-19 pneumonia. Methods: Individuals admitted to two hospitals because of COVID-19 were included if they fulfilled the clinical, radiological, and laboratory criteria for moderate-to-severe disease. Patients were classified according to the first immunomodulatory drug prescribed: anakinra or baricitinib. All subjects were concomitantly treated with corticosteroids, in addition to standard care. The main outcomes were the need for invasive mechanical ventilation (IMV) and in-hospital death. Statistical analysis included propensity score matching and Cox regression model. Results: The study subjects included 125 and 217 individuals in the anakinra and baricitinib groups, respectively. IMV was required in 13 (10.4%) and 10 (4.6%) patients, respectively (p = 0.039). During this period, 22 (17.6%) and 36 (16.6%) individuals died in both groups (p = 0.811). Older age, low functional status, high comorbidity, need for IMV, elevated lactate dehydrogenase, and use of a high flow of oxygen at initially were found to be associated with worse clinical outcomes. No differences according to the immunomodulatory therapy used were observed. For most of the deceased individuals, early interruption of anakinra or baricitinib had occurred at the time of their admission to the intensive care unit. Conclusions: Similar mortality is observed in patients treated with anakinra or baricitinib plus corticosteroids.
Comparison of Safety and Efficiency between Tiger-2 Catheter with Right Radial Artery Access and Judkins Catheter with Left Radial Artery Access
Authors: Klimek Katarzyna , Świątek Mateusz , Klocek Konrad , Tworek Michał , Zwolski Maciej , Milewski Krzysztof , Janas Adam
Published: September 2021

We sought to compare the safety and efficiency of Tiger-2 in the right radial and Judkins catheter in the left radial access. We retrospectively collected data of 487 patients, involving 172 patients after coronary angiography with Judkins on the left radial artery and 315 patients with Tiger-2 on the right radial artery access. There were no differences in baseline characteristics, except for hypertension ratio and mean age. There was a difference in pulse absence on the radial artery. The volume of contrast used was higher in the Judkins group. Both groups differed in the amount of drugs administered (NTG and heparin). Fluorescence times were comparable between groups. Radiation dosage and AK was significantly greater in the Tiger-2 group. The Tiger-2 catheters were significantly more often changed to another type of catheter (100 changes) than the Judkins (12 changes). However, there was no statistical difference in access site change. Judkins with left radial access seems to be a safer option because of the lower radiation exposure and less incidence of complications than Tiger-2 with right radial access, however, it requires a higher volume of contrast.
Is Obesity a Risk or Protective Factor for Open-Angle Glaucoma in Adults? A Two-Database, Asian, Matched-Cohort Study
Authors: Chen Wei-Dar , Lai Li-Ju , Lee Kang-Lung , Chen Tzeng-Ji , Liu Chia-Yen , Yang Yao-Hsu
Published: September 2021

Obesity contributes to multiple systemic disorders; however, extensive discussion regarding obesity and open-angle glaucoma (OAG) remains limited, and conclusions in the existing literature diverge. This study aims to analyze the risk of OAG among obese adults in Taiwan. In this study, adults (aged ≥18 years) with a diagnostic code of obesity or morbid obesity registered in the Longitudinal Health Insurance Database (LHID) 2000 and LHID2005 from 1 January 2001 to 31 December 2010 were included. All adults were traced until the diagnosis of OAG, the occurrence of death, or 31 December 2013. Risk of OAG was significantly higher in obese adults than in non-obese adults after multivariable adjustment (adjusted hazard ratio (aHR): 1.43 (95% confidence interval (CI) 1.11–1.84)/aHR: 1.54 (95% CI 1.23–1.94) in the LHID2000/LHID2005). Both databases demonstrated that young obese adults (aged ≤40 years) had a remarkably increased risk of OAG compared with young non-obese adults (aHR 3.08 (95% CI 1.82–5.21)/aHR 3.81 (95% CI 2.26–6.42) in the LHID2000/LHID2005). This two-database matched-cohort study suggests that obese adults have an increased risk of OAG. In young adults, in particular, obesity could be a potential risk factor of OAG.
Dissociation and Suicidality in Eating Disorders: The Mediating Function of Body Image Disturbances, and the Moderating Role of Depression and Anxiety
Authors: Lewis Yael Doreen , Kapon Shirley , Enoch-Levy Adi , Yaroslavsky Amit , Witztum Eliezer , Stein Daniel
Published: September 2021

In patients with eating disorders (EDs), elevated dissociation may increase the risk of suicide. Bodily related disturbances, depression, and anxiety may intervene in the association between dissociation and suicidality. In this study we aimed to examine the influence of bodily related disturbances, depression, anxiety, severity of ED symptoms, body mass index (BMI), and type and duration of the ED on the relationship between elevated dissociation and elevated suicidality. The study included 172 inpatients: 65 with anorexia nervosa restricting type, 60 with anorexia nervosa binge/purge type, and 37 with bulimia nervosa. Participants were assessed using self-rating questionnaires for dissociation, suicidality, bodily related parameters, and severity of ED symptomatology, depression, and anxiety. We found that dissociation and suicidality were directly associated. In addition, depression and anxiety moderated the mediating role of body image parameters in the association between increased dissociation and increased suicidality. Thus, only in inpatients with high depression and anxiety, i.e., above the median range, body image disturbances were found to mediate the association between dissociation and suicidality. ED-related parameters did not moderate these relationships. Our study demonstrates that in inpatients with EDs, increased dissociation may be significantly associated with increased suicidality, both directly and via the intervening influence of body image, depression, and anxiety.
Comparative Analysis of Lenvatinib and Hepatic Arterial Infusion Chemotherapy in Unresectable Hepatocellular Carcinoma: A Multi-Center, Propensity Score Study
Authors: Lee Jaejun , Han Ji-Won , Sung Pil-Soo , Lee Soon-Kyu , Yang Hyun , Nam Hee-Chul , Yoo Sun-Hong , Lee Hae-Lim , Kim Hee-Yeon , Lee Sung-Won , Kwon Jung-Hyun , Jang Jeong-Won , Kim Chang-Wook , Nam Soon-Woo , Oh Jung-Suk , Chun Ho-Jong , Bae Si-Hyun , Choi Jong-Young , Yoon Seung-Kew
Published: September 2021

The comparative efficacy and safety between lenvatinib and hepatic artery infusion chemotherapy (HAIC) in patients with unresectable hepatocellular carcinoma (HCC) is still unclear. This multicenter historical cohort study enrolled 244 patients who were treated with HAIC (n = 173) or lenvatinib (n = 71) between 2012 and 2020. Propensity score matching (PSM) was performed, and 52 patients were selected per group. Clinical outcomes and safety were compared. Objective response rate (ORR) was not different between the two groups (26.0% vs. 23.1%, p = 0.736). Before PSM, the HAIC group had a higher proportion of Child-Pugh B and portal vein tumor, whereas the lenvatinib group had more patients with extrahepatic metastases, which was adjusted after PSM. There were no differences in progression-free survival (PFS) and overall survival (OS) after PSM (HAIC vs. lenvatinib, median PFS, 3.6 vs. 4.0 months, p = 0.706; median OS 10.8 vs. 7.9 months, p = 0.106). Multivariate Cox-regression showed that alpha-fetoprotein ≤1000 ng/mL was only an associated factor for OS after PSM in all patients (hazard ratio = 0.421, p = 0.011). Subgroup analysis for patients with a high tumor burden beyond the REFLECT eligibility criteria revealed that the HAIC group (n = 29) had a significantly longer OS than did the lenvatinib group (n = 30) (10.0 vs. 5.4 months, p = 0.004). More patients in the HAIC group achieved better liver function than those in the lenvatinib group at the time of best responses. There was no difference in the incidence of grade 3 and 4 adverse events between the two groups. Therefore, lenvatinib is comparable to HAIC in terms of ORR and OS in unresectable HCC meeting REFLECT eligibility criteria.
New Therapies of Liver Diseases: Hepatic Encephalopathy
Authors: Mangini Chiara , Montagnese Sara
Published: September 2021

Hepatic encephalopathy (HE) is a common complication of advanced liver disease which has profound implications in terms of the patients’ ability to fulfil their family and social roles, to drive and to provide for themselves. Recurrent and persistent HE is still a serious management challenge, translating into a significant burden for patients and their families, health services and society at large. The past few years have been characterized by significantly more attention towards HE and its implications; its definition has been refined and a small number of new drugs/alternative management strategies have become available, while others are underway. In this narrative review we summarize them in a pragmatic and hopefully useful fashion.
Implementation of Multi-Exit Neural-Network Inferences for an Image-Based Sensing System with Energy Harvesting
Authors: Li Yuyang , Gao Yuxin , Shao Minghe , Tonecha Joseph T. , Wu Yawen , Hu Jingtong , Lee Inhee
Published: September 2021

Wireless sensor systems powered by batteries are widely used in a variety of applications. For applications with space limitation, their size was reduced, limiting battery energy capacity and memory storage size. A multi-exit neural network enables to overcome these limitations by filtering out data without objects of interest, thereby avoiding computing the entire neural network. This paper proposes to implement a multi-exit convolutional neural network on the ESP32-CAM embedded platform as an image-sensing system with an energy constraint. The multi-exit design saves energy by 42.7% compared with the single-exit condition. A simulation result, based on an exemplary natural outdoor light profile and measured energy consumption of the proposed system, shows that the system can sustain its operation with a 3.2 kJ (275 mAh @ 3.2 V) battery by scarifying the accuracy only by 2.7%.
Friction Stir Processing on the Tribological, Corrosion, and Erosion Properties of Steel: A Review
Authors: Ralls Alessandro , Kasar Ashish , Menezes Pradeep
Published: September 2021

The eventual material degradation of steel components in bio-implant, marine, and high-temperature applications is a critical issue that can have widespread negative ramifications from a safety and economic point of view. Stemming from their tribological, corrosion, and erosion-based properties, there is an increasing need to address these issues effectively. As one solution, surface processing techniques have been proposed to improve these properties. However, common techniques tend to suffer from issues spanning from their practicality to their high costs and negative environmental impacts. To address these issues, friction-stir-processing (FSP) has been one technique that has been increasingly utilized due to its cost effective, non-polluting nature. By inducing large amounts of strain and plastic deformation, dynamic recrystallization occurs which can largely influence the tribological, corrosion, and erosion properties via surface hardening, grain refinement, and improvement to passive layer formation. This review aims to accumulate the current knowledge of steel FSP and to breakdown the key factors which enable its metallurgical improvement. Having this understanding, a thorough analysis of these processing variables in relation to their tribological, corrosion, and erosion properties is presented. We finally then prospect future directions for this research with suggestions on how this research can continue to expand.
Container Shipment Demand Forecasting in the Australian Shipping Industry: A Case Study of Asia–Oceania Trade Lane
Authors: Ubaid Ayesha , Hussain Farookh , Saqib Muhammad
Published: September 2021

Demand forecasting has a pivotal role in making informed business decisions by predicting future sales using historical data. Traditionally, demand forecasting has been widely used in the management of production, staffing and warehousing for sales and marketing data. However, the use of demand forecasting has little been studied in the container shipping industry. Improved visibility into the demand for container shipments has been a long-held objective of industry stakeholders. This paper addresses the shortcomings of both short-term and long-term shipment demand forecasting for the Australian container shipping industry. In this study, we compare three forecasting models, namely, the seasonal auto-regressive integrated moving average (SARIMA), Holt–Winters’ seasonal method and Facebook’s Prophet, to find the best fitting model for short-term and long-term import demand forecasting in the Australian shipping industry. Demand data from three years, i.e., 2016–2018, is used for the Asia–Oceania trade lane. The mean absolute percentage error (MAPE), root mean squared error (RMSE) and 2-fold walk-forward cross-validation are used for the model evaluation. The experiment results observed from the selected metrics suggest that Prophet outperforms the other models in its comparison for container shipment demand forecasting.
Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product
Authors: Chopra Hitesh , Mishra Awdhesh Kumar , Baig Atif Amin , Mohanta Tapan Kumar , Mohanta Yugal Kishore , Baek Kwang-Hyun
Published: September 2021

Mushrooms have remained an eternal part of traditional cuisines due to their beneficial health potential and have long been recognized as a folk medicine for their broad spectrum of nutraceuticals, as well as therapeutic and prophylactic uses. Nowadays, they have been extensively investigated to explain the chemical nature and mechanisms of action of their biomedicine and nutraceuticals capacity. Mushrooms belong to the astounding dominion of Fungi and are known as a macrofungus. Significant health benefits of mushrooms, including antiviral, antibacterial, anti-parasitic, antifungal, wound healing, anticancer, immunomodulating, antioxidant, radical scavenging, detoxification, hepatoprotective cardiovascular, anti-hypercholesterolemia, and anti-diabetic effects, etc., have been reported around the globe and have attracted significant interests of its further exploration in commercial sectors. They can function as functional foods, help in the treatment and therapeutic interventions of sub-optimal health states, and prevent some consequences of life-threatening diseases. Mushrooms mainly contained low and high molecular weight polysaccharides, fatty acids, lectins, and glucans responsible for their therapeutic action. Due to the large varieties of mushrooms present, it becomes challenging to identify chemical components present in them and their beneficial action. This article highlights such therapeutic activities with their active ingredients for mushrooms.
COVID-19 Pandemic Outbreak in the Subcontinent: A Data Driven Analysis
Authors: Singh Bikash Chandra , Alom Zulfikar , Hu Haibo , Rahman Mohammad Muntasir , Baowaly Mrinal Kanti , Aung Zeyar , Azim Mohammad Abdul , Moni Mohammad Ali
Published: September 2021

Human civilization is experiencing a critical situation that presents itself for a new coronavirus disease 2019 (COVID-19). This virus emerged in late December 2019 in Wuhan city, Hubei, China. The grim fact of COVID-19 is, it is highly contagious in nature, therefore, spreads rapidly all over the world and causes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Responding to the severity of COVID-19 research community directs the attention to the analysis of COVID-19, to diminish its antagonistic impact towards society. Numerous studies claim that the subcontinent, i.e., Bangladesh, India, and Pakistan, could remain in the worst affected region by the COVID-19. In order to prevent the spread of COVID-19, it is important to predict the trend of COVID-19 beforehand the planning of effective control strategies. Fundamentally, the idea is to dependably estimate the reproduction number to judge the spread rate of COVID-19 in a particular region. Consequently, this paper uses publicly available epidemiological data of Bangladesh, India, and Pakistan to estimate the reproduction numbers. More specifically, we use various models (for example, susceptible infection recovery (SIR), exponential growth (EG), sequential Bayesian (SB), maximum likelihood (ML) and time dependent (TD)) to estimate the reproduction numbers and observe the model fitness in the corresponding data set. Experimental results show that the reproduction numbers produced by these models are greater than 1.2 (approximately) indicates that COVID-19 is gradually spreading in the subcontinent.
The Optimal Spending Rate versus the Expected Real Return of a Sovereign Wealth Fund
Authors: Aase Knut , Bjerksund Petter
Published: September 2021

We consider a sovereign wealth fund that invests broadly in the international financial markets. The influx to the fund has stopped. We adopt the life cycle model and demonstrate that the optimal spending rate from the fund is significantly less than the fund’s expected real rate of return. The optimal spending rate ensures that the fund will last “forever”. Spending the expected return will deplete the fund with probability one. Moreover, this strategy is inconsistent with optimal portfolio choice. Our results are contrary to the idea that it is sustainable to spend the expected return of a sovereign wealth fund.
Interaction Relationship between Urbanization and Land Use Multifunctionality: Evidence from Han River Basin, China
Authors: Gao Yanli , Li Hongbo , Song Yan
Published: September 2021

Coordinating the interaction between urbanization and land use multifunctionality (LUMF) is of great significance in regional sustainable development. This article explores the interaction relationship between urbanization and LUMF in the Han River Basin (HRB) of China from 2000 to 2018. We used the combination weighting method, coupling coordination degree model, and geographic detector method to examine the coupling relationship and internal mechanism between urbanization and LUMF. The results showed that (1) there exists a significant correlation between urbanization and LUMF, the coupling coordination degree of each county displayed an upward trend throughout the research period, and the whole region has a radiation effect of central cities; (2) from the perspective of the internal mechanism of urbanization demand and the LUMF supply, we found that social urbanization demand is the primary demand for LUMF, while the town living function is the main supply of LUMF for urbanization, which means social urbanization has more influence than economic and population urbanization on LUMF, and the town living function has greater decisive power than agricultural production function and ecological function on urbanization; and (3) the supply and demand-influencing factors between urbanization and LUMF in each sub-region are different, and the upstream is more susceptible to determinants than the midstream and downstream because of the worse natural resource endowment. In conclusion, the critical finding provides not only guidance to understand the relationship between urbanization and LUMF but also suggests that the government should adapt to local conditions when formulating regional development planning.
Assessment of REDD+ MRV Capacity in Developing Countries and Implications under the Paris Regime
Authors: Kim Raehyun , Kim Dong-hwan , Cho Seongsil , Choi Eunho , Park Jinwoo , Lee Sue Kyoung , Son Yowhan
Published: September 2021

The United Nations Framework Convention on Climate Change (UNFCCC) recognized the importance of forests in combating climate change and agreed upon financial support for REDD+ activities in developing countries through the Warsaw REDD+ Framework (WRF). The REDD+ activities for conserving carbon stored in forests to reduce GHG emissions and to enhance the carbon sink function of forests are expected to serve as an important means for achieving the climatic goal. In this study, a set of criteria was devised to assess the REDD+ Measuring, Reporting, and Verifying (MRV) implementation capabilities of developing countries, which was applied to analyze the REDD+ MRV levels in REDD+ countries. Based on the Forest Reference Emission Level/Forest Reference Level (FREL/FRL), National Strategy (NS), National Forest Monitoring System (NFMS) and Safeguard Information Summary (SIS) the countries submitted, 36 REDD+ countries submitted only the FREL/FRL (Group I), while 5 countries fulfilled the WRF requirements and registered REDD+ reduction results (Group II), and 6 received Results-Based Payments (RBP) (Group III). From longest to shortest, the periods for which the International Fund provided support were arranged in the order of Group III, II, and I, verifying the relative importance of international support. From highest to lowest, the overall MRV capability was also arranged in the order of Group III, II, and I, although Group I or Group II was at a higher level than the other groups in some elements. REDD+ countries in the Readiness Phase (Group I) would aim to have the MRV capabilities of Groups II and III to receive RBP, and international support for REDD+ MRV capacity building could enable them to do. However, in addition to the receipt of RBP, REDD+ should be reflected in the Nationally Determined Contribution (NDC) as consistent reduction results at the national GHG inventory level, and the advancement of REDD+ MRV is expected to be a necessary and sufficient condition for REDD+ cooperation under the Paris Agreement cooperative approach framework. For the following groups, international cooperation is essential. Countries in the Readiness Phase need to be supported with the establishment of an MRV framework, which will enable them to achieve REDD+ to receive RBP and be reflected in NDCs. For REDD+ countries that have thus far met the WRF requirements, the REDD+ scope needs to be upscaled to national levels, and the MRV system should be further advanced to establish a cooperative approach system that can achieve more ambitious reduction targets through forests.
The Critical Period Hypothesis for L2 Acquisition: An Unfalsifiable Embarrassment?
Authors: Singleton David , Leśniewska Justyna
Published: September 2021

This article focuses on the uncertainty surrounding the issue of the Critical Period Hypothesis. It puts forward the case that, with regard to naturalistic situations, the hypothesis has the status of both “not proven” and unfalsified. The article analyzes a number of reasons for this situation, including the effects of multi-competence, which remove any possibility that competence in more than one language can ever be identical to monolingual competence. With regard to the formal instructional setting, it points to many decades of research showing that, as critical period advocates acknowledge, in a normal schooling situation, adolescent beginners in the long run do as well as younger beginners. The article laments the profusion of definitions of what the critical period for language actually is and the generally piecemeal nature of research into this important area. In particular, it calls for a fuller integration of recent neurolinguistic perspectives into discussion of the age factor in second language acquisition research.
School-Based Restorative Justice: Lessons and Opportunities in a Post-Pandemic World
Authors: Velez Gabriel M.
Published: September 2021

The COVID-19 pandemic has deeply affected schools and the people within them. The move to remote schooling forced practitioners of school-based restorative justice to adapt and innovate, as theory and practice had almost exclusively focused on in-person instruction. In this paper, I first review some of the challenges, adaptations, and lessons during the pandemic. I then argue that restorative justice in schools offers new and unique potential to address needs of educational communities and the students, educators, and staff within them as in-person instruction returns. Specifically, I suggest it could contribute to rebuilding social connection and community, bolstering mental health, and addressing inequities. Finally, I end with limitations and future directions for considering these extensions and evaluating their impact. School-based restorative justice alone cannot be a panacea for these issues, but could be integrated into other supports and services to address the stark needs of school communities and of the young people whose lives have been so deeply impacted by COVID-19.
Acute Effects of Moderate versus High-Intensity Strength Exercise on Attention and Mood States in Female Physical Education Students
Authors: Znazen Hela , Slimani Maamer , Hadadi Atyh , Alzahrani Turki , Tod David , Bragazzi Nicola Luigi , Souissi Nizar
Published: September 2021

The presumed benefits of exercise/physical activity on the brain are an important public health issue. However, the experimental approach to understanding the effects of physical activity on the brain, and more particularly on cognitive functions, has only been studied recently. In particular, females remain underrepresented in the research, despite having a specific training/exercise adaptation/response. The aim of the present study was to examine the acute effects of high- and moderate-intensity strength exercise (3 sets of 8–10 repetitions and 3 sets of 6 repetitions, respectively, with each session lasting approximately 30 min) on attention and mood states in female physical education students. Forty-six female physical education students (Mage = 20.02 ± 1.05 years, MBody Mass Index = 21.07) volunteered to participate in this study. They were divided into three groups: a moderate-intensity strength exercise group (MISEG: n = 15), a high-intensity strength exercise group (HISEG: n = 16), and a control group (CG: n = 15). Attention and psychological states were assessed using the d2 test, Rating of Perceived Exertion (RPE) and the Brunel Mood Scale (BRUMS) questionnaire, respectively, before and after each session. The data showed that in the MISEG attention increased, in terms of concentration (p = 0.05). RPE values, fatigue and confusion were higher for the HISEG than the CG (p < 0.05) and the MISEG (p < 0.05). Vigour was higher for the MISEG than other groups (p < 0.05). In conclusion, moderate-intensity resistance exercise is an appropriate method to improve attention in female participants. The elevated cognitive performance may be due to the changes in RPE and mood states (fatigue, vigour and confusion subscales).
Multicriteria Model Proposition to Support the Management of Systems of E-Waste Collection
Authors: Fernandes Ciro Henrique de Araújo , Silva Lucio Camara e , Guarnieri Patricia , Vieira Bárbara de Oliveira
Published: September 2021

Background: Considering the global concern in balancing economic growth with environmental sustainability, the study proposes a model to support multicriteria decision-making. From the systematic literature review and bibliometric analysis, there was an increasing trend in studies on electronic waste due to governments, stakeholders, and the population to better address the management of this waste; Methods: We propose a decision model considering some aspects and phases that help from collecting information to support decision making, based on the FITradeoff ordering method, to support policy decisions for managing Waste from Electrical and Electronic Equipment (WEEE) collection systems.; Results: After applying the proposed model, validated based on the perception of a decision-maker working in a federal public agency, we obtained the final classification with ten positions of alternatives; Conclusions: This outcome can assist in decision making and management of the collection of WEEE. In addition, we made recommendations to manufacturers have more responsibility in the design and traceability of the product to guarantee its recovery after disposal effectively.
Sustainable Logistics Network Design for Delivery Operations with Time Horizons in B2B E-Commerce Platform
Authors: Prajapati Dhirendra , Kumar M. Manoj , Pratap Saurabh , Chelladurai H. , Zuhair Mohd
Published: September 2021

In the recent era, the rapidly increasing trend of e-commerce business creates opportunities for logistics service providers to grow globally. With this growth, the concern regarding the implementation of sustainability in logistic networks has received attention in recent years. Thus, in this work, we have focused on the vehicle routing problem (VRP) to deliver the products in a lesser time horizon with driver safety concern considerations in business (B2B) e-commerce platforms. We proposed a sustainable logistics network that captures the complexities of suppliers, retailers, and logistics service providers. A mixed-integer nonlinear programming (MINLP) approach is applied to formulate a model to minimize total time associated with order processing, handling, packaging, shipping, and vehicle maintenance. Branch-and-bound algorithms in the LINGO optimization tool and genetic algorithm (GA) are used to solve the formulated mathematical model. The computational experiments are performed in eight different case scenarios (small-sized problem to large-sized problem) to validate the model.
Potential of Carbon-Based Nanocomposites for Dental Tissue Engineering and Regeneration
Authors: Kang Moon Sung , Jang Hee Jeong , Lee Seok Hyun , Lee Ji Eun , Jo Hyo Jung , Jeong Seung Jo , Kim Bongju , Han Dong-Wook
Published: September 2021

While conventional dental implants focus on mechanical properties, recent advances in functional carbon nanomaterials (CNMs) accelerated the facilitation of functionalities including osteoinduction, osteoconduction, and osseointegration. The surface functionalization with CNMs in dental implants has emerged as a novel strategy for reinforcement and as a bioactive cue due to their potential for mechanical reinforcing, osseointegration, and antimicrobial properties. Numerous developments in the fabrication and biological studies of CNMs have provided various opportunities to expand their application to dental regeneration and restoration. In this review, we discuss the advances in novel dental implants with CNMs in terms of tissue engineering, including material combination, coating strategies, and biofunctionalities. We present a brief overview of recent findings and progression in the research to show the promising aspect of CNMs for dental implant application. In conclusion, it is shown that further development of surface functionalization with CNMs may provide innovative results with clinical potential for improved osseointegration after implantation.
Compressive Behavior of Al-TiB2 Composite Foams Fabricated under Increased Pressure
Authors: Yu Yang , Cao Zhuokun , Wang Jiaqi , Tu Ganfeng , Mu Yongliang
Published: September 2021

The application of increased pressure was used as a strategy to investigate the effect of different cell structures on the mechanical properties of Al-TiB2 composite foams. In situ Al-xTiB2 (x = 5, 10 wt.%) composites were foamed under three different pressures (0.1 MPa, 0.24 MPa, 0.4 MPa) through the liquid melt route. The macro-structure of the composite foams was analyzed in terms of cell size distribution measured by X-ray microcomputed tomography (micro-CT). It was found that the mean cell size decreases, and the cell size distribution range narrows with increasing pressure. Uniaxial compression tests revealed that the stress fluctuation (Rsd) of 10TiB2 foams is larger than that of 5TiB2 foams under the same pressure. Moreover, cell size refinement causes the simultaneous deformation of multi-layer cells, which leads to an enhancement in the energy absorption efficiency and specific energy absorption. The comparison of experimental data with theoretical predictions (G&A model) is discussed.
Microorganism, Carriers, and Immobilization Methods of the Microbial Self-Healing Cement-Based Composites: A Review
Authors: Shen Li’an , Yu Wenlu , Li Lin , Zhang Tong , Abshir Ismail Yusuf , Luo Pingping , Liu Zhuangzhuang
Published: September 2021

Low tensile strength, poor elastic modulus, and complex concrete cracking work condition are almost unavoidable due to the intrinsic brittleness. To deal with concrete maintenance and durability, microbial self-healing concretes have been rapidly developed and widely applied recently. The microbial self-healing can specifically patch fractures as well as boost the concrete structure’s capacity, durability, and permeability. This paper presents the state-of-the-art in the microbe induced self-healing in cement-based composites. The microorganism and carriers were classified according to the working theory and repair effects. Additionally, the precise efficiency and effect of various technologies are also evaluated for microbial immobilization. Based on the literature review and summary from the perspective of microorganism, carriers, and immobilization methods, challenges and further works are discussed.
Effect of the Position of the Boundary Rivets on the Quality of Riveted Single Strap Butt Joints
Authors: Zhao Anan , Zhang Yongliang , Zhu Chunrun , Zhong Zhengwei , Bi Yunbo
Published: September 2021

Riveting is widely used in aircraft manufacturing. The strap butt joint is often used in the aircraft’s main bearing area such as the aircraft docking area. The connection quality affects the reliability and safety of the aircraft directly. To study the effect of the rivet position on the connection quality of the strap butt joints, this paper analyzed the distribution of stress around the rivet hole at different positions by the finite element method, and then further analyzed the influence of the different rivet layouts on the connection quality of the strap butt joints by experiments. The static load tensile failure test of the joints was carried out, and the obtained tensile strength and failure mode of the strap butt joints showed that the main static tensile failure form of the single strap butt joint is that the whole rivets is sheared and the connecting sheets are separated. By changing the layout of different rivets, the connection strength can be maximized by reducing the outer row spacing (ORSD) of rivets. The results can be used for reference in the design of the riveting structure of aircraft panels.
Evaluation of Anthropogenic Substrate Variability Based on Non-Destructive Testing of Ground Anchors
Authors: Wyjadłowski Marek , Kozubal Janusz V. , Zięba Zofia , Steshenko Dmitri , Krupowies Dariusz
Published: September 2021

The purpose of this paper is to describe the variability of soil rheological properties based on research carried out using load tests of ground anchors under complex geotechnical conditions. The heterogeneity of soil should always be considered when designing geotechnical constructions. In the present case, the earthwork created at the Warsaw Slope revealed an embankment of anthropogenic origin, located in a geologically and geomorphologically complex area of the Vistula valley slope. Excavation protection was anchored mainly in soils of anthropogenic origin. When the acceptance tests of the ground anchor were completed, the subsoil randomness was confirmed using nondirect, geostatistical methods. A standard solid rheological model with nonlinear fitting to the data was used. This model was established to describe the creeping activity of the ground anchor more accurately. The characteristics of man-made embankments were described using the parameters obtained with the rheological model of the subsoil.
Influence of 1.5 wt.% Bi on the Microstructure, Hardness, and Shear Strength of Sn-0.7Cu Solder Joints after Isothermal Annealing
Authors: Ramli Mohd Izrul Izwan , Salleh Mohd Arif Anuar Mohd , Sandu Andrei Victor , Amli Siti Farahnabilah Muhd , Said Rita Mohd , Saud Norainiza , Abdullah Mohd Mustafa Al Bakri , Vizureanu Petrica , Rylski Adam , Chaiprapa Jitrin , Nabialek Marcin
Published: September 2021

This manuscript reports the isothermal annealing effect on the mechanical and microstructure characteristics of Sn-0.7Cu-1.5Bi solder joints. A detailed microstructure observation was carried out, including measuring the activation energy of the intermetallic compound (IMC) layer of the solder joints. Additionally, the synchrotron µX-ray fluorescence (XRF) method was adopted to precisely explore the elemental distribution in the joints. Results indicated that the Cu6Sn5 and Cu3Sn intermetallic layers thickness at the solder/Cu interface rises with annealing time at a rate of 0.042 µm/h for Sn-0.7Cu and 0.037 µm/h for Sn-0.7Cu-1.5Bi. The IMC growth’s activation energy during annealing is 48.96 kJ mol-1 for Sn-0.7Cu, while adding Bi into Sn-0.7Cu solder increased the activation energy to 55.76 kJ mol−1. The µ-XRF shows a lower Cu concentration level in Sn-0.7Cu-1.5Bi, where the Bi element was well dispersed in the β-Sn area as a result of the solid solution mechanism. The shape of the IMC layer also reconstructs from a scallop shape to a planar shape after the annealing process. The Sn-0.7Cu hardness and shear strength increased significantly with 1.5 wt.% Bi addition in reflowed and after isothermal annealing conditions.
Methylcellulose–Cellulose Nanocrystal Composites for Optomechanically Tunable Hydrogels and Fibers
Authors: Hynninen Ville , Patrakka Jani , Nonappa
Published: September 2021

Chemical modification of cellulose offers routes for structurally and functionally diverse biopolymer derivatives for numerous industrial applications. Among cellulose derivatives, cellulose ethers have found extensive use, such as emulsifiers, in food industries and biotechnology. Methylcellulose, one of the simplest cellulose derivatives, has been utilized for biomedical, construction materials and cell culture applications. Its improved water solubility, thermoresponsive gelation, and the ability to act as a matrix for various dopants also offer routes for cellulose-based functional materials. There has been a renewed interest in understanding the structural, mechanical, and optical properties of methylcellulose and its composites. This review focuses on the recent development in optically and mechanically tunable hydrogels derived from methylcellulose and methylcellulose–cellulose nanocrystal composites. We further discuss the application of the gels for preparing highly ductile and strong fibers. Finally, the emerging application of methylcellulose-based fibers as optical fibers and their application potentials are discussed.
Experimental and Numerical Investigation into Failure Modes of Tension Angle Members Connected by One Leg
Authors: Bernatowska Edyta , Ślęczka Lucjan
Published: September 2021

This paper presents the results of experimental and numerical tests on angle members connected by one leg with a single row of bolts. This study was designed to determine which failure mode governs the resistance of such joints: net section rupture or block tearing rupture. Experimental tests were insufficient to completely identify the failure modes, and it was necessary to conduct numerical simulations. Finite element analysis of steel element resistance based on rupture required advanced material modelling, taking into account ductile initiation and propagation of fractures. This was realised using the Gurson–Tvergaard–Needleman porous material model, which allows for analysis of the joint across the full scope of its behaviour, from unloaded state to failure. Through experimental testing and numerical simulations, both failure mechanisms (net section and block tearing) were examined, and an approach to identify the failure mode was proposed. The obtained results provided experimental and numerical evidence to validate the strength function used in design standards. Finally, the obtained results of the load capacity were compared with the design procedures given in the Eurocode 3′s current and 2021 proposed editions.
A Smart Tool Holder Calibrated by Machine Learning for Measuring Cutting Force in Fine Turning and Its Application to the Specific Cutting Force of Low Carbon Steel S15C
Authors: Tseng Liang-Wei , Hu Teng-Shan , Hu Yuh-Chung
Published: September 2021

Real-time monitoring of the cutting force in the machining process is critical for improving machining accuracy, optimizing the machining process, and optimizing tool lifetime; however, the dynamometers are too expensive to be widely used by machine tool users. Therefore, this paper presents a simple and cheap apparatus—a smart tool holder—to measure the cutting force of turning tools in the finishing turning. The apparatus does not change the structure of the turning tool. It consists of a tool holder and a piezoresistive force sensor foil, and transmits the signal through Bluetooth wireless communication. Instead of dealing with the circuit hardware, this paper uses the Artificial Neural Network (ANN) model to successfully calibrate the warm-up shift problem of the piezoresistive force sensor. Such a software method is simple, and considerably cheaper than the hardware method. For the force measurement capability of the smart tool holder, the cross-interference between orthogonal forces are very small and thus can be ignored. The force reading of the smart tool holder possesses high repeatability for the same turning parameters and high accuracy within the experiment groups. The authors apply the smart tool holder to cut the low carbon steel S15C, and to determine its specific cutting force in fine turning. The resulting fine turning force model agrees very well with the measurement. Its mean absolute deviation is 3.87% and its standard deviation is 1.55%, which reveals that the accuracy and precision of the smart tool holder and the fine turning force model are both good.
Systematic Literature Review Predictive Maintenance Solutions for SMEs from the Last Decade
Authors: Hassankhani Dolatabadi Sepideh , Budinska Ivana
Published: September 2021

Today, small- and medium-sized enterprises (SMEs) play an important role in the economy of societies. Although environmental factors, such as COVID-19, as well as non-environmental factors, such as equipment failure, make these industries more vulnerable, they can be minimized by better understanding the concerns and threats these industries face. Only a few SMEs have the capacity to implement the innovative manufacturing technologies of Industry 4.0. The system must be highly adaptable to any equipment, have low costs, avoid the need of doing complex integrations and setups, and have future reliability due to the rapid growth of technology. The goal of this study was to provide an overview of past articles (2010–2020), highlighting the major expectations, requirements, and challenges for SMEs regarding the implementation of predictive maintenance (PdM). The proposed solutions to meet these expectations, requirements, and challenges are discussed. In general, in this study, we attempted to overcome the challenges and limitations of using smart manufacturing—PdM, in particular—in small- and medium-sized enterprises by summarizing the solutions offered in different industries and with various conditions. Moreover, this literature review enables managers and stakeholders of organizations to find solutions from previous studies for a specific category, with consideration for their expectations and needs. This can be significantly helpful for small- and medium-sized organizations to save time due to time-consuming maintenance processes.
On the Reachability of a Feedback Controlled Leontief-Type Singular Model Involving Scheduled Production, Recycling and Non-Renewable Resources
Authors: De la Sen Manuel , Ibeas Asier , Alonso-Quesada Santiago
Published: September 2021

This paper proposes and studies the reachability of a singular regular dynamic discrete Leontief-type economic model which includes production industries, recycling industries, and non-renewable products in an integrated way. The designed prefixed final state to be reached, under discussed reachability conditions, is subject to necessary additional positivity-type constraints which depend on the initial conditions and the final time for the solution to match such a final prescribed state. It is assumed that the model may be driven by both the demand and an additional correcting control in order to achieve the final targeted state in finite time. Formal sufficiency-type conditions are established for the proposed singular Leontief model to be reachable under positive feedback, correcting controls designed for appropriate demand/supply regulation. Basically, the proposed regulation scheme allows fixing a prescribed final state of economic goods stock in finite time if the model is reachable.
An Exterior Algebraic Derivation of the Euler–Lagrange Equations from the Principle of Stationary Action
Authors: Colombaro Ivano , Font-Segura Josep , Martinez Alfonso
Published: September 2021

In this paper, we review two related aspects of field theory: the modeling of the fields by means of exterior algebra and calculus, and the derivation of the field dynamics, i.e., the Euler–Lagrange equations, by means of the stationary action principle. In contrast to the usual tensorial derivation of these equations for field theories, that gives separate equations for the field components, two related coordinate-free forms of the Euler–Lagrange equations are derived. These alternative forms of the equations, reminiscent of the formulae of vector calculus, are expressed in terms of vector derivatives of the Lagrangian density. The first form is valid for a generic Lagrangian density that only depends on the first-order derivatives of the field. The second form, expressed in exterior algebra notation, is specific to the case when the Lagrangian density is a function of the exterior and interior derivatives of the multivector field. As an application, a Lagrangian density for generalized electromagnetic multivector fields of arbitrary grade is postulated and shown to have, by taking the vector derivative of the Lagrangian density, the generalized Maxwell equations as Euler–Lagrange equations.