bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase III Study of Adjuvant Ipilimumab (3 or 10 mg/kg) Versus High-Dose Interferon Alfa-2b for Resected High-Risk Melanoma: North American Intergroup E1609
Authors: Tarhini Ahmad A. , Lee Sandra J. , Hodi F. Stephen , Rao Uma N. M. , Cohen Gary I. , Hamid Omid , Hutchins Laura F. , Sosman Jeffrey A. , Kluger Harriett M. , Eroglu Zeynep , Koon Henry B. , Lawrence Donald P. , Kendra Kari L. , Minor David R. , Lee Carrie B. , Albertini Mark R. , Flaherty Lawrence E. , Petrella Teresa M. , Streicher Howard , Sondak Vernon K. , Kirkwood John M.
Published: December 2019

PURPOSE

Phase III adjuvant trials have reported significant benefits in both relapse-free survival (RFS) and overall survival (OS) for high-dose interferon alfa (HDI) and ipilimumab at 10 mg/kg (ipi10). E1609 evaluated the safety and efficacy of ipilimumab at 3 mg/kg (ipi3) and ipi10 versus HDI.

PATIENTS AND METHODS

E1609 was a phase III trial in patients with resected cutaneous melanoma (American Joint Committee on Cancer 7th edition stage IIIB, IIIC, M1a, or M1b). It had 2 coprimary end points: OS and RFS. A 2-step hierarchic approach first evaluated ipi3 versus HDI followed by ipi10 versus HDI.

RESULTS

Between May 2011 and August 2014, 1,670 adult patients were centrally randomly assigned (1:1:1) to ipi3 (n = 523), HDI (n = 636), or ipi10 (n = 511). Treatment-related adverse events grade ≥ 3 occurred in 37% of patients receiving ipi3, 79% receiving HDI, and 58% receiving ipi10, with adverse events leading to treatment discontinuation in 35%, 20%, and 54%, respectively. Comparison of ipi3 versus HDI used an intent-to-treat analysis of concurrently randomly assigned patient cases (n = 1,051) and showed significant OS difference in favor of ipi3 (hazard ratio [HR], 0.78; 95.6% repeated CI, 0.61 to 0.99; P = .044; RFS: HR, 0.85; 99.4% CI, 0.66 to 1.09; P = .065). In the second step, for ipi10 versus HDI (n = 989), trends in favor of ipi10 did not achieve statistical significance. Salvage patterns after melanoma relapse showed significantly higher rates of ipilimumab and ipilimumab/anti–programmed death 1 use in the HDI arm versus ipi3 and ipi10 ( P ≤ .001).

CONCLUSION

Adjuvant therapy with ipi3 benefits survival versus HDI; for the first time to our knowledge in melanoma adjuvant therapy, E1609 has demonstrated a significant improvement in OS against an active control regimen. The currently approved adjuvant ipilimumab dose (ipi10) was more toxic and not superior in efficacy to HDI.
Membrane Response of Human Erythrocytes Exposed to a Pressure of 140 MPa
Authors: Yamaguchi Takeo , Miyazaki Masayuki
Published: December 2019

When human erythrocytes are subjected to high pressures for 30 min at 37 °C, hemolysis and vesiculation begin to occur at a pressure of 140 MPa. Response of the erythrocytes to 140 MPa is expected to provide unique information about the membrane structure. So, we examined the effect of freshness and trypsin treatment of human erythrocytes on the membrane response to 140 MPa. Upon exposure of old erythrocytes to the pressure, the size of erythrocytes reduced gradually due to vesiculation and fragmentation without significant hemolysis, irrespective of trypsin treatment. In trypsin-treated fresh erythrocytes, on the other hand, the suppression of vesiculation and fragmentation under pressure resulted in distinct hemolysis that was characterized by release of large vesicles from mother cells and also by critical hemolysis volume. ESI-MS of lipids demonstrated that the lipid compositions of 140 MPa-induced vesicles were independent of the freshness and trypsin treatment of erythrocytes. Interestingly, the membranes of 140 MPa-induced vesicles contained low cholesterol and high levels of phosphatidylserine and phosphatidylinositol, compared with erythrocyte membranes. Thus, the properties of 140 MPa-induced vesicles reflect partially the initial response of erythrocytes to that pressure.
Differences in Respiratory Muscle Responses to Hyperpnea or Loaded Breathing in COPD
Authors: RODRIGUES ANTENOR , LOUVARIS ZAFEIRIS , DACHA SAUWALUK , JANSSENS WIM , PITTA FABIO , VOGIATZIS IOANNIS , GOSSELINK RIK , LANGER DANIEL
Published: December 2019

Introduction

We aimed to compare acute mechanical and metabolic responses of the diaphragm and rib cage inspiratory muscles during two different types of respiratory loading in patients with chronic obstructive pulmonary disease.

Methods

In 16 patients (age, 65 ± 13 yr; 56% male; forced expiratory volume in the first second, 60 ± 6%pred; maximum inspiratory pressure, 82 ± 5%pred), assessments of respiratory muscle EMG, esophageal pressure (Pes) and gastric pressures, breathing pattern, and noninvasive assessments of systemic (V˙O2, cardiac output, oxygen delivery and extraction) and respiratory muscle hemodynamic and oxygenation responses (blood flow index, oxygen delivery index, deoxyhemoglobin concentration, and tissues oxygen saturation [StiO2]), were performed during hyperpnea and loaded breathing.

Results

During hyperpnea, breathing frequency, minute ventilation, esophageal and diaphragm pressure–time product per minute, cardiac output, and V˙O2 were higher than during loaded breathing (P < 0.05). Average inspiratory Pes and transdiaphragmatic pressure per breath, scalene (SCA), sternocleidomastoid, and intercostal muscle activation were higher during loading breathing compared with hyperpnea (P < 0.05). Higher transdiaphragmatic pressure during loaded breathing compared with hyperpnea was mostly due to higher inspiratory Pes (P < 0.05). Diaphragm activation, inspiratory and expiratory gastric pressures, and rectus abdominis muscle activation did not differ between the two conditions (P > 0.05). SCA–blood flow index and oxygen delivery index were lower, and SCA–deoxyhemoglobin concentration was higher during loaded breathing compared with hyperpnea. Furthermore, SCA and intercostal muscle StiO2 were lower during loaded breathing compared with hyperpnea (P < 0.05).

Conclusion

Greater inspiratory muscle effort during loaded breathing evoked larger rib cage and neck muscle activation compared with hyperpnea. In addition, lower SCA and intercostal muscle StiO2 during loaded breathing compared with hyperpnea indicates a mismatch between inspiratory muscle oxygen delivery and utilization induced by the former condition.
Exercise Effects on Multiple Sclerosis Quality of Life and Clinical–Motor Symptoms
Authors: TOLLÁR JÓZSEF , NAGY FERENC , TÓTH BÉLA E. , TÖRÖK KATALIN , SZITA KINGA , CSUTORÁS BENCE , MOIZS MARIANN , HORTOBÁGYI TIBOR
Published: December 2019

Introduction

Different therapies can improve clinical and motor symptoms of multiple sclerosis (MS) similarly, but studies comparing the effects of different exercise therapies on clinical and motor outcomes are scant. We compared the effects of exergaming (EXE), balance (BAL), cycling (CYC), proprioceptive neuromuscular facilitation (PNF), and a standard care wait-listed control group (CON) on clinical and motor symptoms and quality of life (QoL) in people with MS (PwMS).

Methods

PwMS (n = 68, 90% female; age, 47.0 yr; Expanded Disability Status Scale score 5–6) were randomized into five groups. Before and after the interventions (five times a week for 5 wk), PwMS were tested for MS-related clinical and motor symptoms (Multiple Sclerosis Impact Scale-29 (MSIS-29), primary outcome), QoL (EuroQol Five Dimensions Questionnaire), symptoms of depression, gait and balance ability (Tinetti Assessment Tool), static and dynamic balance and fall risk (Berg Balance Scale), walking capacity (6-min walk test), and standing posturography on a force platform.

Results

EXE, BAL, and CYC improved the MSIS-29 scores similarly. EXE and CYC improved QoL and walking capacity similarly but more than BAL. Only EXE improved gait and balance scores (Tinetti Assessment Tool). EXE and BAL improved fall risk and standing balance similarly but more than CYC. PNF and CON revealed no changes. The EuroQol Five Dimensions Questionnaire moderated the exercise effects on the MSIS-29 scores only in EXE. Changes in QoL and changes in the MSIS-29 scores correlated (R
2 = 0.73) only in EXE.

Conclusion

In conclusion, BAL and CYC but EXE in particular, but not PNF, can improve clinical and motor symptoms and QoL in PwMS (Expanded Disability Status Scale score 5 to 6), expanding the evidence-based exercise options to reduce mobility limitations in PwMS.
Altitude and its inverse association with abdominal obesity in an Andean country: a cross-sectional study
Authors: Pajuelo-Ramírez Jaime , Torres-Aparcana Harold , Agüero-Zamora Rosa , Quispe Antonio M.
Published: December 2019

Background: Abdominal obesity represents an accurate predictor of overall morbidity and mortality, which is worrisome because it is also continuously increasing across Andean countries. However, its relationship with altitude remains unclear. The objective of this study was to assess the association between altitude and abdominal obesity in Peru, and how sociodemographic variables impact this association.

Methods: We estimated the prevalence of abdominal obesity in Peru and analyzed its association with altitude using the data from the 2012-2013 National Household Survey (ENAHO). During this survey, a representative sample of Peruvians was screened for abdominal obesity, using waist circumference as a proxy, and the Adult Treatment Panel III guidelines cutoffs.

Results: Data were analyzed from a sample of 20 489 Peruvians (51% male). The prevalence of abdominal obesity was estimated at 33.6% (95% CI: 32.5 to 34.6%). In Peru, altitude was significantly and inversely associated with abdominal obesity, decreasing with higher altitudes: 1500-2999 meters above mean sea level (MAMSL) vs <1500 MAMSL, adjusted prevalence rate [aPR]= 0.90 (95% CI: 0.84 to 0.96); ≥3000 MAMSL vs <1500 MAMSL, aPR= 0.78 (95% CI: 0.72 to 0.84), when adjusting by age, gender and residence area (rural/urban). However, this association was significantly modified by age and gender (p< 0.001).

Conclusion: Abdominal obesity is highly prevalent in Peru and decreases significantly with altitude, but age and gender modify this association. Thus, abdominal obesity appears to affect older women from low altitudes more than younger men from high altitudes.
LEAFY COTYLEDONs: old genes with new roles beyond seed development
Authors: Niu De , He Yuehui
Published: December 2019

Seed development is a complex process and consists of two phases: embryo morphogenesis and seed maturation. LEAFY COTYLEDON (LEC) transcription factors, first discovered in Arabidopsis thaliana several decades ago, are master regulators of seed development. Here, we first summarize molecular genetic mechanisms underlying the control of embryogenesis and seed maturation by LECs and then provide a brief review of recent findings in the role of LECs in embryonic resetting of the parental ‘memory of winter cold’ in Arabidopsis. In addition, we discuss various chromatin-based mechanisms underlying developmental silencing of LEC genes throughout the post-embryonic development to terminate the embryonic developmental program.
Changes in the Legislation on the National Payment System
Authors: Smirnov E.
Published: December 2019

Last summer, the Russian Parliament, by adopting Federal Laws of August 2, 2019 No. 264-FZ and July 3, 2019 No. 173-FZ, introduced serious changes to the current legislation on the national payment system. According to parliamentarians, this will allow the state to signifi cantly strengthen control over the payment services market in order to maintain the integrity of the country’s payment space.
Advertising Expenses: Accounting and Taxation
Authors: Parasotskaya N.
Published: December 2019

The article is devoted to the issues of advertising costs in organizations, their reflection in accounting and tax accounting. Today, organizations that are stably working and effectively developing their activities pay due attention to the marketing strategy, where advertising, various advertising products and methods of its distribution occupy a significant place.
Active-Passive Accounts in the Methodology of Accounting
Authors: Kolchugin Sergey
Published: December 2019

Th e article considers the problem of active-passive accounts in theory and methodology of Russian accounting. On the example of the materialistic theory of two classes of accounts, in which there are no active-passive accounts, proves the possibility of constructing a consistent accounting theory. Th e theoretical inconsistency of introducing active-passive accounting accounts into modern theory and practice is proved. In conclusion, a new defi nition of active and passive accounts is given from the standpoint of the formal-axiomatic accounting theory.
Application of Edible and Biodegradable Starch-Based Films in Food Packaging: A Systematic Review and Meta-Analysis
Authors: Sadeghizadeh-Yazdi Jalal , Habibi Masoud , Kamali Ali Akbar , Banaei Mahdi
Published: December 2019

In recent years, natural polymers such as starch have been widely considered as alternatives to plastics derived from petroleum derivatives in the production of packaging films. Currently, modified starches with new functional features are available that can be used in the production of the above mentioned films. The aim at this study is a systematic review and meta-analysis of application of edible and biodegradable starch-based films in food packaging. At first all of the studies related to our title by using some keywords (edible and biodegradable starch-based films and food packaging) searched for English databases; Google, Google scholar, PubMed, Embase, CINAHL, PsycInfo, SCOPUS and ISI web of Science during the 2010 to 2018 was run consisting a predefined inclusion and exclusion factors. Inclusion and exclusion criteria were: papers related to edible and biodegradable starch-based films and food packaging, papers were English, types of papers were original and all the papers were free full text. As a result, related to inclusion and exclusion criteria papers were found and analyses. Data were collected based on study characteristics, edible and biodegradable starch-based films, food packaging. In the initial search, 589 articles were found that after reviewing the titles and abstract articles and removing repetitive and non-related, 33 possible related articles were examined. Of these, 24 articles were omitted from the abstract because of lack of access to the original article and lack of sufficient information. Finally, 13 papers were included in the study. Due to novel research on the application of bio-degradable biofilms in the packaging industry of food, starch is one of the most promising and promising sources. Different needs in the food packaging industry for bio-films have led to the diverse sources of starch being studied, because each source has its own specific characteristics. The properties of films obtained from starch indicated the rigidity and reduced flexibility of the films. To prevent this and the corresponding effects on the film, other polymers can be used as additive compounds. Extending the use of starch structure techniques and the use of this material in combination with other materials to reduce the inherent weaknesses of this natural polymer has led to its further development in various industries, especially packaged industries. Starch is a proper substitute for polymers extracted from oil derivatives. In order to improve the characteristics of the produced films, a high number of compounds can be added to the matrix, and various variations can be applied during the processing. Optimizing conditions will produce transparent, non-odorous, non-flavored, and color-free films with improved mechanical, optical and deterrent features.
Proportion and Associated Factors of Vitamin B12 Deficiency - A Retrospective Laboratory-Based Study
Authors: Sowndarya K , Basavaiah Sridevi Hanaganahalli , Shenoy Ramya , Hegde Anupama
Published: December 2019

Vitamin B12 is a vital micronutrient involved in the hemopoetic, neurologic and cardio-metabolic function. Various factors are responsible for B12 deficiency, which can lead to anemia and irreversible neurological manifestations. The proportion of deficiency is not well known and hence studied in the hospital setup. The associated factors of B12 deficiency were also deduced in different age groups. Laboratory data of the past two years on vitamin B12 (B12), folate and red blood cell (RBC) indices were compiled. Based on B12 values, subjects were grouped as deficient, subclinical deficiency and normal. RBC indices especially, Mean corpuscular volume (MCV) was compared among all three groups. The deficient group was further categorized based on age to know the associated factors as per the diagnosis or medical impression recorded. The frequency of B12 and folic acid deficiency was found to be 28% and 18.8% respectively. The deficiency was more frequently detected in the younger age group (18-30years) with inadequate nutrition, pregnancy and vegetarian diet being the most frequently associated factors. Hyperthyroidism was an add-on in the mid-age group. In subjects aged 51-70 years, disorders of intestine, gastric surgery, cancer and pernicious anemia were the attributing factors. MCV > 100fL was found only in 4.8% of the B12 deficient population. Only 28% of B12 deficiency could be conclusively detected. Pregnancy and nutritional status were the most commonly associated factors of B12 deficiency. The use of MCV for the detection of B12 deficiency did not seem reliable.
Biochemical Composition and Sensory Evaluation of Desert Date Flowers (Balanites aegyptiaca Del) Infusion
Authors: Amadou Issoufou , Ilagouma Amadou Tidjani , Soumana Oumarou Samna , Cheng Xiang-Rong
Published: December 2019

Desert date tea (DDT) is originated from the local Balanites aegyptiaca flowers infusion. Thus, the objectif of this work is to evaluate the antioxidant activity, phenolic contents and the sensory quality of DDT. The antioxidant activity was determined, total phenols and total flavonoids were quantified. Total phenols and flavonoids followed LC-MS analysis, and sensory evaluation were also carried out. Substantial quantities were recorded for both quantity of phenolic and flavonoids accounted for 3.06 mg galic acid /g and 21.60 mg rutin /g respectively. Compounds like narcissin, hirsutrin, quercetrin, ilixantrin, rutin, isorhamnetin and diverse flavone were identified. Lower antioxidant activity and overall acceptability of DDT were noticed than that of quercetin and commercial green tea. The sensory result showed again that the green tea and DDT scored almost the same in flavor character. It can be concluded that DDT could be widely used as a source of polyphenols with antioxidant and sensory quality potential; therefore, introducing numerous health benefits for the consumer.
Geographic variation in a restricted-range endemic dragonfly Gomphurus ozarkensis (Odonata: Gomphidae), with description of a new subspecies

Authors: PATTEN MICHAEL A. , BARNARD ALEXANDRA A. , SMITH BRENDA D.
Published: December 2019

The geographic distribution of Gomphurus ozarkensis (Westfall, 1975), a species described to science only four decades ago, is confined to a four-state area in the central United States: southeastern Kansas, eastern Oklahoma, western and northern Arkansas, and southern Missouri. Its small range has led some to classify it a species of conservation concern. We examined geographic variation in the species, which despite its small range exists in three distinct subpopulations: one in the Ouachita Mountains of western Arkansas and southeastern Oklahoma; one on the Ozark Plateau of northeastern Oklahoma, southeastern-most Kansas, southern Missouri, and northern Arkansas; and one in the Osage/Flint hills of southeastern Kansas and northeastern Oklahoma. Clinal variation is evident in the extent of yellow on the terminal abdominal segments and the extent to which certain thoracic stripes are fused. A population in a separate watershed basin in the southern Osage Hills of Oklahoma is taxonomically distinct, with some phenotypic characters tending toward G. externus (Hagen, 1858). We describe this population as a new subspecies of G. ozarkensis.
Long-wave infrared magnetic mirror based on Mie resonators on conductive substrate
Authors: Ye Ming , Li Shi-Qiang , Gao Yang , Crozier Kenneth B.
Published: December 2019

Metal films are often used in optoelectronic devices as mirrors and/or electrical contacts. In many such devices, however, the π-phase shift of the electric field that occurs upon reflection from a perfect electric conductor (for which a metal mirror is a reasonable approximation) is undesirable. This is because it results in the total electric field being zero at the mirror surface, which is unfavorable if one wishes for example to enhance absorption by a material placed there. This has motivated the development of structures that reflect light with zero phase shift, as these lead to the electric field having an anti-node (rather than node) at the surface. These structures have been denoted by a variety of terms, including magnetic mirrors, magnetic conductors, and high impedance surfaces. In this work, we experimentally demonstrate a long-wave infrared device that we term a magnetic mirror. It comprises an array of amorphous silicon cuboids on a gold film. Our measurements demonstrate a phase shift of zero and a high reflectance (of ∼90%) at a wavelength of 8.4 µm. We present the results of a multipole analysis that provides insight into the physical mechanism. Lastly, we investigate the use of our structure in a photodetector application by performing simulations of the optical absorption by monolayer graphene placed on the cuboids.
High-sensitivity photoacoustic gas detector by employing multi-pass cell and fiber-optic microphone
Authors: Zhang Bo , Chen Ke , Chen Yewei , Yang Beilei , Guo Min , Deng Hong , Ma Fengxiang , Zhu Feng , Gong Zhenfeng , Peng Wei , Yu Qingxu
Published: December 2019

A high-sensitivity photoacoustic (PA) spectroscopy (PAS) system is proposed for dual enhancement from both PA signal excitation and detection by employing a miniaturized Herriott cell and a fiber-optic microphone (FOM). The length of the optical absorption path of the PA cell is optimized to ∼374 mm with 17 reflections. The volume of the PA cell is only 622 µL. The FOM is a low-finesse fiber-optic Fabry-Pérot (FP) interferometer. The two reflectors of the FP cavity are formed by a fiber endface and a circular titanium diaphragm with a radius of 4.5 mm and a thickness of 3 µm. A fast demodulated white-light interferometer (WLI) is utilized to measure the absolute FP cavity length. The acoustic responsivity of the FOM reaches 126.6 nm/Pa. Several representative PA signals of trace acetylene (C2H2) are detected to evaluate the performance of the trace gas detector in the near-infrared region. Experimental results show that the minimum detectable pressure (MDP) of the FOM is 3.8 µPa/Hz1/2 at 110 Hz. The noise equivalent minimum detection concentration is measured to be 8.4 ppb with an integration time of 100 s. The normalized noise equivalent absorption (NNEA) coefficient is calculated as 1.4×10−9 cm−1·W·Hz−1/2.
WDM photon pair source stabilized in a wide temperature range with cascaded optical nonlinearities and DFG monitoring
Authors: Arahira Shin , Murai Hitoshi , Sasaki Hironori
Published: December 2019

In this paper, we report a multi-channel wavelength division multiplexed (WDM) photon pair source operating in a wide temperature range. The photon pair generation rates in multiple WDM channels were stabilized against changes in the operation temperature by combining the spectral flatness of cascaded optical nonlinearities (cascaded sum frequency generation/spontaneous parametric downconversion) with a differential frequency generation monitoring feedback system. The proposed method was experimentally validated using a type-I periodically poled LiNbO3 ridge waveguide device as the photon pair source. We successfully generated 16 WDM photon pairs at almost the same rate (0.024358 ± 0.000631 pairs/s/Hz), even when the operating temperature was varied from 27.01 °C to 60.16 °C.
Foveated holographic near-eye 3D display
Authors: Chang Chenliang , Cui Wei , Gao Liang
Published: December 2019

We present a foveated rendering method to accelerate the amplitude-only computer-generated hologram (AO-CGH) calculation in a holographic near-eye 3D display. For a given target image, we compute a high-resolution foveal region and a low-resolution peripheral region with dramatically reduced pixel numbers. Our technique significantly improves the computation speed of the AO-CGH while maintaining the perceived image quality in the fovea. Moreover, to accommodate the eye gaze angle change, we develop an algorithm to laterally shift the foveal image with negligible extra computational cost. Our technique holds great promise in advancing the holographic 3D display in real-time use.
Antimicrobial resistance patterns of commensal Escherichia coli isolated from feces of non-diarrheic dogs in Grenada, West Indies
Authors: Amadi Victor A. , Hariharan Harry , Amadi Ozioma A. , Matthew-Belmar Vanessa , Nicholas-Thomas Roxanne , Perea Marta Lanza , Carter Kenrith , Rennie Eugene , Kalasi Keith , Alhassan Andy , Kabuusu Richard M. , Alozie Grant Ugochukwu , Fields Paul J. , Pinckney Rhonda , Sharma Ravindra
Published: December 2019

Background and Aim: There is currently no published information on the prevalence and antimicrobial susceptibility patterns of commensal Escherichia coli in dogs of Grenada origin. Monitoring antimicrobial resistance helps in the empirical selection of antibiotics. This study determined the occurrence of E. coli including the O157:H7 serotype in feces of non-diarrheic dogs of Grenada origin and the antibiotic resistance pattern of the E. coli isolates.

Materials and Methods: Fecal samples from 142 of the 144 (98.6%) dogs were culture positive for E. coli. Selection of up to three colonies from each of the 142 E. coli-positive samples yielded a total of 402 E. coli isolates, which were analyzed for the presence of non-sorbitol fermenting colonies, and O157-agglutination.

Results: Of the 402 E. coli isolates, 30 (7.5%) were non-sorbitol fermenters. However, none of the 402 isolates gave a positive reaction (O157:H7) to the E. coli O157:H7 latex kit. Antimicrobial susceptibility tests against 12 antibiotics revealed low resistance rates to all the tested antibiotics except for tetracycline (Te) (23.4%), cephalothin (CF) (13.2%), and ampicillin (AM) (7.7%). Thirty-nine out of the 402 (9.7%), E. coli isolates were resistant to two or more antibiotics of different classes.

Conclusion: This is the first report of isolation and antimicrobial susceptibilities of commensal E. coli from non-diarrheic dogs in Grenada. Some of the isolates (39/402 isolates, 9.7%) were resistant to multiple antibiotics. This study showed that presently, dogs in Grenada should not be considered a reservoir for the E. coli O157:H7 serotype and for multiple antibiotic-resistant E. coli strains. Among the 402 E. coli isolates, the resistance rate to drugs other than Te, CF, and AM was very low.
БЕЗОПАСНОСТЬ МИГРАНТОВ И НАСЕЛЕНИЯ ПРИНИМАЮЩЕЙ ТЕРРИТОРИИ В ОЦЕНКАХ ЖИТЕЛЕЙ АЛТАЙСКОГО КРАЯ
Authors: Ноянзина Оксана Евгеньевна , Максимова Светлана Геннадьевна , Омельченко Дарья Алексеевна , Наумова Евгения Сергеевна
Published: December 2019

В статье использованы данные, полученные в рамках исследования особенностей проявления доверия и оценок социальной безопасности населения Алтайского края (2019, n = 621) в возрасте от 15 до 75 лет, на основе выделения в общей выборке населения региона подвыборки коренного и диаспорального сообщества, имеющего опыт транзитных перемещений. Получены как оценки личной безопасности перемещающегося населения, так и оценки безопасности регионального социума, принимающего иностранных мигрантов. Большинство респондентов, сами являясь мигрантами, не так давно принятыми в региональном сообществе, отрицательно относятся к мигрантам. Видимо, являясь гражданами России, адаптировавшись в принимающем сообществе, транзитные мигранты становятся на иные, близкие к аборигенному «стационарному» населению позиции. При этом усиливает негативное отношение к мигрантам осознание не исходящей от них угрозы, а, наоборот, ее отсутствие. В представлениях населения ощущение безопасности связано в первую очередь с присутствием мигрантов в российском приграничье, далее имеет значение распространенность негативных социальных стереотипов о миграции и мигрантах, усиливает опасность и низкий социально-экономический статус региона проживания.
PENGUATAN PENDIDIKAN KARAKTER PEDULI SESAMA MELALUI KEGIATAN EKSTRAKURIKULER RELAWAN
Authors: Muhamadi Sani , Hasanah Aan
Published: December 2019

Penelitian ini bertujuan untuk mengungkapkan hasil pembinaan karakter peduli sesama melalui kegiatan ekstrakurikuler relawan. Metode yang digunakan adalah deskriptif analitis dengan pendekatan kualitatif. Teknik pengumpulan data adalah observasi, wawancara dan studi dokumentasi. Temuan penelitian ini: Proses penguatan karakter peduli sesama melalui kegiatan ekstrakurikuler relawan dilakukan dengan kegiatan pelatihan rutin setiap minggu, kegiatan terjadwal bulanan berupa pembersihan sungai, masjid, dan lingkungan sekitar, serta kegiatan insidental memberikan bantuan ke daerah-daerah terdampak bencana alam dan kemanusiaan. Hasilnya siswa menunjukkan sikap peduli yang semakin kuat, baik secara individual maupun secara organisasional. Faktor pendukung dalam penguatan karakter peduli sesama adalah  visi misi dan tujuan madrasah,  keteladanan guru dan staf, kegiatan-kegiatan yang dilaksanakan di sekolah, serta pelibatan dalam kegiatan di masyarakat. Sedangkan faktor penghambatnya adalah kurangnya dana untuk melaksanakan kegiatan, dan faktor izin orangtua dalam kegiatan-kegiatan di area bencana.
TRANSINTERNALISASI NILAI-NILAI KEPESANTRENAN MELALUI KONSTRUKSI BUDAYA RELIGIUS DI SEKOLAH
Authors: Bali Muhammad Mushfi El Iq , Susilowati Susilowati
Published: December 2019

This paper aims to analyze students' moral decadence problems in school. Brawls, free sex and narcotics on students is evidence of school failure in building the religious character of students. One of the educational institutions that have succeeded in building the religious character of students is pesantren. This success was proven by a little reporting of deviant behaviour among santri. By using descriptive qualitative methods, researchers want to reveal the profile of public schools that not only excellent academic achievement but are also able to produce students who have a religious culture so as to avoid various deviant behaviours. The religious culture is formed through the internalization of the values of the pesantren, namely to incorporate Islamic values through habituation manifested in school programs like a pesantren. The implication of this study is to internalize the value of pesantren in schools that can shape the religious character of students. Students can avoid bad behaviour.

Abstrak

Tulisan ini bertujuan untuk menelaah masalah dekadensi moral yang banyak dialami pelajar di sekolah. Tawuran, sex bebas, dan narkotika dikalangan pelajar merupakan wujud nyata kegagalan sekolah dalam membangun karakter religius siswa. Salah satu lembaga pendidikan yang dianggap berhasil membangun karakter religius siswa adalah pesantren. Keberhasilan tersebut terbukti dengan minimnya pemberitaan perilaku menyimpang dikalangan santri. Dengan menggunakan metode kualitatif deskriptif, peneliti hendak mengungkap profil sekolah umum yang tidak hanya unggul dalam prestasi akademik namun juga mampu mencetak siswa yang memiliki budaya religius sehingga terhindar dari berbagai perilaku menyimpang. Budaya religius tersebut terbentuk melalui internalisasi nilai-nilai kepesantrenan yakni menanamkan nilai-nilai Islam melalui pembiasaan yang diwujudkan dalam program-program sekolah layaknya sebuah pesantren. Implikasi dari studi ini adalah internalisasi nilai-nilai kepesantrenan di sekolah dapat membentuk karakter religius siswa sehingga dapat mencegah siswa dari perilaku menyimpang.
Served on a Silver Platter working Towards an Academic Research Data Concierge Service
Authors: Collura Michael A. , Dressler Virginia A , Hawkins Michael , Kavulic Michael
Published: December 2019

This article will discuss the development of a research concierge service aimed at supporting the unique data needs of researchers at each stage of the research lifecycle. Although based on work at one institution, a North American academic 4-year research university, the presented strategies are transferable to many different types of institutions. The concept behind this service emerged when staff members from the Office of Research, Information Technology, and University Libraries embarked on an endeavour, by way of a newly formed collaborative working group, to identify disparate research support services around campus. Steps will be suggested to assess and align existing support services as well as uncover gaps in service within an institution. A review of organisational models from other institutions with complementary services will also be included. The article will also examine the challenges faced by our institution in creating this collaborative group and the new service approach.
Research Data Management in Higher Educational Institutions
Authors: Bhardwaj Raj Kumar
Published: December 2019

Editorial Note for Special Issue on Research Data Management
Selecting fracturing interval for the exploitation of tight oil reservoirs from logs: a case study
Authors: Liu Zhidi , Shi Yujiang , Zhou Jinyu , Wang Changsheng , Ma Tinghao , Yang Junru , Shi Mengxuan
Published: December 2019

The optimal selection of fracturing interval for the exploitation of tight oil reservoirs is very important for formulating a development program. In this study, the reservoir quality and the reservoir fracability are evaluated, and the criteria for the optimal selection of the fracturing interval are established, using the tight reservoir in the the Qing I Member of Qingshankou Formation in the Daqingzijing Oilfield of China as the study site. The results indicate that the porosity, the oil saturation and the effective thickness of tight reservoir are keys to optimizing the fracturing interval. The brittleness index and the difference coefficient among the horizontal stresses in the reservoir have a strong influence on fracability. The stress difference coefficient in the reservoir is smaller and the reservoir develops microfractures, the complex mesh fractures are easier to occur during fracturing. The stress difference between the reservoir and the surrounding bed is small and the thickness of the surrounding bed is thin, it is easy to communicate with adjacent oil-bearing layers when fracturing.
Efficient synthesis of palladium nanoparticles using guar gum as stabilizer and their applications as catalyst in reduction reactions and degradation of azo dyes
Authors: Anjum Farhana , Gul Saima , Khan Mohammad Iqbal , Khan Murad Ali
Published: December 2019

Palladium is very expensive metal and has numerous applications especially as a versatile hydrogenation and dehydrogenation catalyst for chemical reactions. The main hurdle in its wide use is the high materials cost. In the present study a cost effective palladium nano catalyst was prepared using the green method of synthesis with guar gum as capping and reducing agent. The formations of palladium nanoparticles were confirmed by UV-spectrophotometer while for morphology and nature, SEM and XRD were performed that confirmed the crystalline nature of PdNPs and proved the roughly spherical shape of nanoparticles. FT-IR analysis showed different functional groups of reducing agent and proved that guar gum have the ability to stabilized as well as to reduce the Pd (II) to Pd (0). Specific signal for the palladium is present in EDX spectra that further confirmed the formation of PdNPs. The catalytic efficiency was studied using the hydrogenation of 4-nitrophenol. Rate constant of prepared nano-catalyst was 0.1436/min, its efficiency, TON, TOF, in above mention reaction is 90.83, 27.78, and 185.2/hrs, respectively. Data obtained proved synthesized PdNPs to be efficient heterogeneous catalyst for the reduction of 4-NP and for the degradation of azo dyes.
Previsit Planning Improves Pneumococcal Vaccination Rates in Childhood-Onset SLE
Authors: Sivaraman Vidya , Wise Kelly A. , Cotton William , Barbar-Smiley Fatima , AlAhmed Ohoud , MacDonald Darby , Lemle Stephanie , Yildirim-Toruner Cagri , Ardoin Stacy P. , Ardura Monica I.
Published: December 2019

BACKGROUND:

Childhood-onset systemic lupus erythematosus (c-SLE) is a complex autoimmune disease that requires systemic immunosuppressive therapy. Infections are the second leading cause of death in these patients, with invasive pneumococcal infections being a major preventable cause of morbidity and mortality. Pneumococcal vaccination is recommended in this population; however, vaccination rates remain low.

METHODS:

The plan-do-study-act method of quality improvement was applied. We calculated baseline vaccination rates for pneumococcal conjugate and pneumococcal polysaccharide vaccines in patients with c-SLE in the rheumatology clinic from January 2015 to August 2016. We developed an age-based algorithm to simplify the vaccination guidelines. The clinical pharmacist and nurses performed weekly previsit planning to update vaccine records, make targeted recommendations, and ensure vaccine availability. The primary outcome measure was the percentage patients with of c-SLE seen per month who had received age-appropriate pneumococcal vaccination.

RESULTS:

The percentage of children receiving at least 1 pneumococcal vaccine increased from 24.9% to 92.7% by 12 months. By 18 months, the compliance rate with both pneumococcal vaccines increased from 2.5% to 87.3%, with sustained results. No serious adverse events or disease flares were reported.

CONCLUSIONS:

By identifying the major barriers to pneumococcal vaccination in our population with c-SLE, we significantly improved vaccination rates while decreasing time burden on providers. We attribute our success to a team-based quality improvement approach and plan to implement alerts in the electronic health record to streamline the process.
O afastamento de dilma roussef: afetos e discursos em disputa na política
Authors: Prado José Luiz Aidar , Bueno Vinicius Prates da Fonseca
Published: December 2019

Este texto examina os sentidos produzidos no Facebook por dois articuladores(Frente Brasil Popular e Vem pra Rua) entre os vários movimentos a favor ou contra o afastamento da presidente Dilma Roussef, em abril de 2016. A análise é feita a partir da teoria do discurso de Laclau e da semiótica tensiva de Zilberberg e Fontanille. As questões de pesquisa são: quais foram os contratos de comunicação e os temas construídos pelos enunciadores situados em lados opostos do espectro político? Quais são as oposições semânticas fundamentais? Que discursos políticos atravessam essas convocações? Quais foram os pontos nodais desses discursos? Como se constrói em cada caso a figura do “povo”? Que afetos um e outro movimento põe em cena? Em termos de uma teoria do acontecimento como se posicionam um e outro enunciador? Em termos tensivos, como entender esses movimentos a partir de uma semiótica da triagem e da mistura? Finalmente, como pensar a construção da democracia a partir dessa polarização?
A imagem em movimento e os espaços da arte contemporânea: outras formulações do audiovisual
Authors: De Jesus Eduardo Antonio
Published: December 2019

O texto reflete sobre as passagens e contaminações históricas e contemporâneas entre arte e cinema ancorando principalmente nas dinâmicas do espaço, mostrando como se efetua uma vertente do audiovisual contemporâneo que se coloca na intercessão entre a tradicional sala escura de exibição, a caixa preta, e os espaços de exposição como museus e galerias, o cubo branco. Construímos um breve contexto histórico, para em seguida nos determos nas dinâmicas do espaço a partir da noção de heterotopia em Foucault para analisar algumas obras exibidas na 32ª Bienal de São Paulo (2016).
Cinema tentacular: poéticas das profundezas e a imagem do Octópode
Authors: Felinto Erick
Published: December 2019

Este trabalho examina uma série de diferentes obras nas quais os polvos e cefalópodes em geral podem ser pensados como criaturas particularmente “cinematográficas”. Das representações populares, em filmes como Tentacles (1977), aos documentários, como Amours de la Pieuvre (1965), ou a filmes experimentais, como Mon Homme (Poulpe) (2016), a meta deste percurso será esclarecer, por um caminho “tentacular”, por que razão a animalidade constitui uma das vias de acesso privilegiadas ao cinema, segundo André Bazin e Raymond Bellour.
“Fake news”, pós-verdade e sociedade do capital: o irracionalismo como motor da desinformação jornalística
Authors: De Souza Rafael Bellan Rodrigues
Published: December 2019

Investiga-se a constituição histórico-social do fenômeno da pós-verdade e, no âmbito jornalístico, das chamadas “fake news”, analisando-as como decorrentes de processos econômicos, sociais e ideológicos característicos das mutações no sistema metabólico do capital. Assim, busca-se compreender a relação entre as mudanças da ordem econômica e a consolidação e intensificação da pós modernidade, dimensão ideológica e cultural do capitalismo tardio, em sua recente inserção na esfera cotidiana, a pós-verdade. Por meio do debate em torno das categorias lukacsianas de irracionalismo e decadência ideológica, propõe-se uma reflexão sobre os fundamentos ontológicos da desinformação jornalística e, por conseguinte, da perda da realidade objetiva por ela promovida.
“Tão famosos que você provavelmente nunca ouviu falar”: uma reflexão sobre a “nova” categoria de sujeitos influenciadores do consumo
Authors: Antunes Amanda , Azevedo Marcella
Published: December 2019

Apesar de ser uma categoria relativamente recente, os influenciadores digitais apresentam crescimento exponencial e significativa relevância, tanto no discurso midiático, como nas práticas do marketing, disputando estes espaços com outras figuras notórias. O objetivo deste artigo é discutir as rupturas e continuidades na concepção e na prática desse fenômeno, a partir de uma análise comparativa entre as tradicionais celebridades e essa “nova” categoria de influenciadores. Para tanto, foram utilizados como recursos metodológicos a pesquisa bibliográfica e documental, além da observação das ações de marcas − entre elas, o endosso de produtos por influenciadores digitais. Como resultado, de forma sucinta, infere-se-se que as celebridades despertam no público uma admiração de caráter aspiracional, distantes que são da sua audiência.  Já a chave para compreensão dos influenciadores digitais é sua grande proximidade com o comum e cotidiano, se posicionando muito próximos a seus seguidores.
Plataformas algorítmicas: interpelação, perfilamento e performatividade
Authors: De Castro Julio Cesar Lemes
Published: December 2019

Este trabalho de articulação teórica, ancorado em pesquisa bibliográfica, considera como plataformas algorítmicas as redes de acesso controlado nas quais o usuário é governado via algoritmos e sua identidade é redefinida continuamente com base em dados fornecidos por ele ou extraídos de sua atividade. Para entender as circunstâncias em torno da interação do usuário com essas plataformas, o artigo propõe e desenvolve categorias que adaptam e reformulam elementos conceituais de diversas origens. A interpelação refere-se à abordagem do usuário pelo algoritmo, que é recalibrada a cada iteração e cuja agência pode distribuir-se em instâncias de alteridade representadas pelo algoritmo ou por outros atores. Tal abordagem opera por meio da definição ad hoc de perfis a partir da combinação de traços do usuário, o perfilamento. Este, por sua vez, consolida-se em virtude de sua assunção pelo usuário, que corresponde à performatividade.
Dealing with jokes in the ESL class: a pedagogical proposal centred on comprehension
Authors: Cruz Manuel Padilla
Published: December 2019

This paper makes a pedagogical proposal to delve into jokes in the ESL classroom and sensitise learners to their complexity. It consists of five instructional phases and is based, on the one hand, on another proposal to teach the pragmatics of speech acts in an L2. On the other hand, this proposal relies on a relevance-theoretic classification of jokes made on the basis of the various linguistic, cultural and cognitive factors that humorists exploit in their production. Since it only centres on how different types of jokes can be distinguished and what their correct comprehension involves, it has a cognitive orientation and does not address issues connected with joke production. The proposal is devised for ESL students with an advanced level of English and ultimately seeks to develop their metalinguistic, meta-cultural and metacognitive abilities as a way of enabling them to grasp the humorousness of funny texts, appraise them and react to them in an appropriate way.***Lidando com piadas na aula de ESL: uma proposta pedagógica centrada na compreensão***Este artigo traz uma proposta pedagógica para aprofundar as piadas na sala de aula de ESL (Inglês como língua estrangeira, na tradução para a língua portuguesa) e sensibilizar os alunos a respeito de sua complexidade. Ela consiste em cinco fases instrucionais que, por um lado, baseia-se em outra proposta de ensino da pragmática dos atos de fala em uma L2 e, por outro lado, baseia-se em uma classificação teórica da relevância das piadas feitas com base nos vários fatores linguísticos, culturais e cognitivos que os humoristas exploram em sua produção. Como a proposta se concentra apenas em como os diferentes tipos de piadas podem ser distinguidos e em qual a correta compreensão envolvida, ela tem uma orientação cognitiva e não aborda questões relacionadas à produção da piada. A proposta é elaborada para estudantes de ESL com um nível avançado de inglês e, por conseguinte, busca desenvolver suas habilidades metalinguísticas, meta-culturais e metacognitivas como uma maneira de permitir-lhes compreender o humor de textos engraçados, avaliá-los e reagir a eles apropriadamente.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI LIKUIDITAS BANK SYARIAH DI INDONESIA MENGGUNAKAN METODE VECTOR ERROR CORRECTION MODEL (VECM)
Authors: FATHURRAHMAN AYIF , RUSDI FIRSHA
Published: December 2019

This study aims to analyze the factors that affect the liquidity of Islamic banks in Indonesia. The analysis is carried out using sequential monthly data published by Bank Indonesia in the period 2010 to 2018. The variables used are internal factors (Capital Adequacy Ratio (CAR), Return On Assets (ROA)) and external factors (SBI Inflation and Interest Rates) ) The method used in this study is the Vector Error Corection Model (VECM). Based on the results of the study show that in the short term, the variable CAR, ROA, Inflation and SBI interest rates positively and significantly affect FDR. Whereas in the long term, the CAR variable and inflation have a significant positive effect on FDR, the ROA variable negatively influences FDR. And the variable SBI interest rate does not have a significant effect on FDR.
FINANCIAL CONTROL BETWEEN RASHIDUN CALIPHS AND THE LATE 11TH CENTURY
Authors: ISMAIL BASSEM , HAMIDAH HAMIDAH
Published: December 2019

Many modern concepts of financial control and its types that are now adopted have already existed in the Islamic state from Prophet Muhammad message through the Rashidun Caliphs and then the Umayyad and Abbasid through establishing Baitul Mal. This article try to investigate the concept of financial control and types in Islam and the historical development of financial control in Islam. Also clarify the principles of financial control in Islam. The research based on the descriptive approach through the use of scientific studies which dealt with the subject of research, in addition to the historical approach through the use of historical evidence in the way enhancing the opinions presented by the research in the rooting of its themes from the Islamic point of view. This paper give an attention to the behavioral principle and self-control of individuals when working in different areas of life in general and financial in particular, as they have direct causes of increased efficiency and effectiveness financial control system (FCS).