bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFECTS OF AQUATIC THERAPY ON SLEEP QUALITY AND QUALITY OF LIFE IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Iamonti Vinicius Carlos , Vasconcelos Kelly da Silva , Sato Vanessa Luzia Baggio , Machado Renata Saltiel , Da Silva Hyanna Mayra Messias Lina , De Oliveira Natália Cristina , Kumpel Claudia
Published: January 2019

Contextualization: Hypertension is a disease that essentially affects the balance of vasodilator and vasoconstrictor mechanisms, causing an increase in vessels blood pressure that may compromise tissue irrigation and cause damage to the organs. Cases may develop to a severe clinical presentation and affect sleep quality and quality of life of the patients. Objective: To evaluate whether aquatic therapy has a beneficial effect on sleep quality and quality of life in patients with hypertension. Method: All patients completed Berlin, Epworth, Minichal and Pittsburgh questionnaires, Hospital Anxiety and Depression Scale (HAD), and an open questionnaire. Patients participated in twice weekly sessions of aquatic therapy for 5 months. Results: The average age of the sample was 58 ± 8 years old. There was no significant improvement in sleep quality, evaluated by Pittsburgh questionnaire (p = 0.05), however, enhancements in daytime sleepiness (p = 0.0048) as well as in the number of hours of sleep at every 24 hours (p = 0.04), quality of life (p = 0.002) and level of anxiety (p = 0.012). Conclusion: Aquatic therapy is an effective alternative therapy for improving quality of life, decreasing anxiety, daytime sleepiness and reducing the chance of developing sleep apnea.
MOBILIDADE TORÁCICA: CONFIABILIDADE DA CIRTOMETRIA
Authors: Castro Antônio Adolfo Mattos de
Published: January 2019

A técnica de cirtometria é um método objetivo e simples que avalia quantitativamente a mobilidade torácica, mas a escassez e as contradições literárias quanto à padronização metodológica e os valores de referência do coeficiente respiratório para os perímetros torácicos podem comprometer à fidedignidade dos dados obtidos. Objetivo: O presente estudo objetiva testar a reprodutibilidade da técnica de cirtometria e verificar a variabilidade nos resultados intraexaminador e interexaminadores. Métodos: O estudo foi realizado com 22 mulheres saudáveis, entre 19 e 25 anos, estatura de 1,50 a 1,70 cm, índice de massa corpórea entre 19 e 24Kg e não fumantes. A técnica foi realizada de forma duplo cego, por quatro investigadores: (dois docentes com prática e dois discentes com conhecimento teórico) .O indivíduo foi avaliado com o tórax desnudo, posição em sedestação. A avaliação constava de medidas dos perímetros: axilar, xifóide e basal. Solicitando para que o indivíduo direcionasse o ar para região a ser mensurada auxiliando com incentivo verbal. Foi considerado coeficiente respiratório a diferença entre a inspiração e expiração máximas. Resultados e conclusões: houve significativa reprodutibilidade da técnica de cirtometria entre e intra-avaliadores. O estudo sugere que quando utilizada uma mesma metodologia a técnica de cirtometria pode ser considerada fidedigna e a prática adquirida com os dias de aplicação da técnica não influenciou nos resultados do coeficiente respiratório.
PERFIL DA COMPOSIÇÃO CORPORAL E DENSIDADE MINERAL ÓSSEA DE TABAGISTAS EM UM CENTRO DE REFERÊNCIA EM REABILITAÇÃO E ASSISTÊNCIA À SAÚDE.
Authors: Souza Anselmo Cordeiro de , Miguel Amanda de Souza , Oliveira Izabel Maria de , Acevedo Martha Cecilia Leon , Portes Leslie Andrews , Porto Elias Ferreira
Published: January 2019

O tabagismo tem sido redefinido como uma doença crônica co-ocorrente de importância para outras doenças crônicas não transmissíveis e agravos a saúde. Assim esta investigação objetiva traçar o perfil da composição corporal e óssea de pacientes tabagistas em um Centro de Referência em Reabilitação e Assistência à Saúde. Trata-se de investigação seccional, de métodos de procedimentos próprios da pesquisa epidemiológica descritiva e de abordagem quantitativa. A pesquisa realizou-se em um Centro de Referência em Reabilitação e Assistência à Saúde no município de São Paulo. Aplicou-se um questionário sociodemográfico e fatores relacionados, o instrumento Fagerström de avaliação da dependência nicotínica, e caracterização socioeconômica realizada por meio do Critério Brasil 2015. Realizou-se Absortometria Radiológica de Raio X de Dupla Energia – DEXA de corpo total, coluna lombar, colo do fêmur e fêmur total.  Avaliaram-se 24 tabagistas com idade entre 45 e 75 anos, de ambos os sexos, idade média de 58,6±5,9 anos, Índice de Massa Corporal médio de 26,7±3,4, maioria do sexo feminino 16 (66%).  Grau de dependência nicotínica prevalente baixa 09 (37,5%), 16 (66%) declararam ser estressados, e 14 (58%) pertencem a classe sócio econômica C2, 10 (41%) tem o ensino fundamental incompleto. A saúde óssea nesta amostra entre mulheres apresentou proporções de osteopenia e osteoporose respectivamente: na coluna lombar 31,3% e 25%, na cabeça do fêmur 56,2% e 6,2%, fêmur total 31,3% e 12,5%, no corpo total 31,3% e 6,2%. Já os homens apresentaram osteopenia e osteoporose respectivamente nas seguintes proporções:  coluna lombar 37,5% e 25,0%, cabeça do fêmur 62,5% e 12,5%, fêmur total direito e corpo total 37.5% e 12,5%. Houve baixo Índice Massa Magra para mulheres e homens respectivamente em 18,7% e 12,5%. Já em relação ao Índice de Gordura corporal para mulheres e homens respectivamente: sobrepeso 68,7% e 50,0%, obeso classe I 6,2% e 25%. Os indivíduos tabagistas avaliados apresentam maiores perdas percentuais de massa muscular e densidade mineral óssea em todos os segmentos investigados, do que as prevalências em não tabagistas no cenário nacional.
ATENÇÃO PSICOLÓGICA VOLTADA AOS FAMILIARES ACOMPANHANTES DE PACIENTES HOSPITALIZADOS
Authors: Rodrigues Sudário Eliana Cristina , Sousa Bruna Maria Genuino , Duarte Suzani Marques Palma
Published: January 2019

Este estudo tem como objetivo verificar a perspectiva dos familiares acompanhantes sobre o atendimento psicológico recebido na rede hospitalar. Trata-se de uma pesquisa de campo de natureza qualitativa com análise descritiva. Como instrumento de coleta de dados, foi utilizado um questionário de opinião sobre o acolhimento e satisfação do atendimento psicológico recebido em hospitais pelo familiar acompanhante da pessoa hospitalizada. Outros aspectos gerais sobre os cuidados recebidos no ambiente hospitalar também foram investigados. Os resultados evidenciaram que o familiar acompanhante qualifica como satisfatórias as seguintes categorias: 1) às disposições hospitalares e equipe médica; 2) o cumprimento do seu papel enquanto familiar acompanhante; e 3) o atendimento psicológico recebido.
Spolni stereotipi in diskriminacija žensk na trgu dela: psihološki pogled
Authors: Svetek Mojca
Published: January 2019

Pričujoči prispevek je pregled spoznanj (socialne) psihologije na področju diskriminacije žensk na trgu dela in delovnih mestih. Prispevek pojasnjuje, kako spolni stereotipi vplivajo na zaznavanje žensk in moških, pričakovanja na delovnem mestu in različne standarde ocenjevanja žensk in moških. Izpostavi, kateri psihološki mehanizmi so ključni pri vzdrževanju diskriminacije na trgu dela, in predstavi, kakšne so napovedi razvoja spolnih stereotipov v prihodnosti. Članek v pretežni meri obravnava ovire, s katerimi se ženske soočajo pri dostopanju do vodstvenih položajev, saj je ta vidik v psihološki literaturi do sedaj prejel največ pozornosti, kljub temu pa obravnavani mehanizmi diskriminacije niso omejeni na zgornjo plast trga dela.
Avant-propos du dossier sur les ressources alimentaires pour les animaux d’élevage
Authors: BAUMONT René
Published: January 2019

Les ressources alimentaires sont au cœur de la plupart des enjeux de durabilité auxquels font face les systèmes d’élevage. Ce dossier de la revue INRA Productions Animales fait le point sur la production et les flux de matières premières végétales dans le monde, l’Union Européenne et la France, et sur quelques questions relatives aux coproduits et à l’autonomie protéique, à l’évaluation des ressources alimentaires, à l’efficience de leur conversion par les animaux et à l’impact environnemental des aliments.
Physical Properties of Seeds of Eleven Fir Species
Authors: Kaliniewicz Zdzisław , Markowski Piotr , Anders Andrzej , Jadwisieńczak Krzysztof , Żuk Zbigniew , Krzysiak Zbigniew
Published: January 2019

Research Highlights: The correlations between the analyzed physical properties of seeds and seed mass were determined. The results were analyzed to determine most effective seed separation devices for the evaluated fir species. Background and Objectives: Information about the variations and correlations between the physical properties of seeds is essential for designing and modeling seed processing operations such as seed separation. The aim of this study was to determine the range of variations in the basic physical properties of seeds of selected fir species, and to identify the correlations between these attributes for the needs of the seed sorting processes. Materials and Methods: Terminal velocity, thickness, width, length, the angle of external friction and mass were determined in the seeds of 11 fir species. The measured parameters were used to calculate the geometric mean diameter, three aspect ratios, sphericity index and the specific mass of each seed. Results: The average values of the basic physical properties of the analyzed seeds were determined in the following range: terminal velocity – from 4.8 to 7.1 m s-1, thickness – from 1.76 to 3.22 mm, width – from 3.29 to 5.57 mm, length – from 5.44 to 11.06 mm, angle of external friction – from 26 to 33°, and mass – from 7.9 to 48.3 mg. The seeds of Sierra white fir where most similar, whereas the seeds of balsam fir differed most considerably from the seeds of the remaining fir species. Conclusions: Fir seeds should be sorted primarily with the use of mesh sieves with longitudinal openings to obtain fractions with similar seed mass and to eliminate the need for dewinging.
Optimization of Value Measurement Methods
Authors: Abdullahi Kabir Bindawa
Published: January 2019

This paper addresses the issues of methodological problems and limitations regarding measuring values. A short scan review of values measurement methods from psychological and ethnobotanical approaches was made to enumerate some of those shortcomings. A new methodological approach, named Kab’s Value Survey (KVS) was proposed and compared with other well adopted methods based on some important criteria to assess its suitability, uniqueness and novelty. The results of the comparisons shows that KVS for its considerations to the theoretical explanations distinguishes itself over other methods of value measurement in the sense that the methodological approach employed is more broad in scope and applications, simple, specific and reliable in terms of instruments for data collection, psychometric data analysis, and of course data presentation. The method however solved some of the criticized limitations that exist in other well adopted methods of values measurement from psychological and ethnobotanical perspectives.
Prediction Models to Control Aging Time in Red Wine
Authors: Astray G , Mejuto JC , Martinez-Martinez V , Nevares I , Alamo-Sanza M , Simal-Gandara Jesus
Published: January 2019

A combination of physical-chemical analysis has been used to monitor the aging of red wines from D.O. Toro (Spain). The changes in the chemical composition of wines that occur along aging time can be permitted to discriminate wine samples collected after one, four, seven and ten months of aging. Different computational models were used to develop a good authenticity tool to certificate wines. In this research different models have developed: Artificial Neural Network models (ANNs), Support Vector Machine (SVM) and Random Forest (RF) models. The results obtained for the ANN model developed with sigmoidal function in the output neuron and the RF model permit to determine the aging time, with an average absolute percentage deviation below 1% and it can conclude that these two models have demonstrated its capacity as a valid tool to predict the wine age.
A Rough Calculation Relating the Extremely Small Cosmological Constant to the Extremely Large QFT Vacuum Energy Density
Authors: Cornwall Remi
Published: January 2019

This enquiry follows the investigation into a propulsion system purportedly utilising the QED vacuum as reactive momenergy. The QFT vacuum is contentious because the “naïve” value for it is extraordinarily large, yet on the cosmic scale it is hardly present. This begs the question as to whether it is really real and further highlights the problem between General Relativity on very large scales, with Quantum Mechanics on very small scales. We find a mathematical procedure that: to the 1st order removes the “embarrassing” QFT vacuum constant from the Einstein tensor and then covers nearly all of the 120 orders of magnitude difference between the Cosmological Constant and Vacuum Energy by introducing it as an higher order correction in (G/c4)3. There is a proviso for further work, that the difference of a few orders we calculate, might be made up by considering fluctuations or running constants in the QFT vacuum and Cosmic Inflation.
The Complicated Body in Motion: Rediscovering the Mechanical Stimulations in Cell Models of Human Disease
Authors: Wong Tzyy-Yue , Tseng Yu-Kai , Yeh Tung-Chen , Jhong Rong-Chang , Wang Yue-Fang , Chang Hui-Yu , Cheng Pei-Wen
Published: January 2019

Thought runs through the mind like blood runs through our body to keep us alive. Like the mind, the body does not stay inert and is in constant motion. Not a single cell in our body is left inert unless cell is under stress or dying. These scenarios are reflected upon when a person is sick, the person lies in bed with less movement; however, is active when the person is healthy. The topic of mechanical stimulation has emerged due to the increasing understanding of the physical stimulations we face each day. Further understanding of the mechanically-regulated mechanism can help us explore the pathological events in a disease. Here, we reviewed the role of sensory proteins in pathological events that are observed in cardiomyopathy, cancer, respiratory, renal, obesity, genetics, physical injury and bacterial infection. Taken together, sensory proteins are mechanically-activated which assist reception of external physical stimulation and convert into biochemical to trigger intracellular signaling cascade.
Bioavailable menthol (Transient Receptor Potential Melastatin-8 agonist) induces energy expending phenotype in differentiating adipocytes
Authors: Khare Pragyanshu , Chauhan Aakriti , Kumar Vibhu , Kaur Jasleen , Mahajan Neha , Kumar Vijay , Gesing Adam , Chopra Kanwaljit , Kondepudi Kanthi Kiran , Bishnoi Mahendra
Published: January 2019

Recent evidences support a role of menthol, a TRPM8 agonist, in enhanced energy expenditure, thermogenesis and BAT-like activity in classical WAT depots in TRPM8 dependent and independent manner. The present study was designed to analyze whether oral and topical administration of menthol is bioavailable at subcutaneous adipose tissue and is sufficient to induce desired energy expenditure effects directly. GC-FID was performed to study menthol bioavailability in serum and subcutaneous white adipose tissue following oral and topical administration. Further, 3T3L1 adipocytes were treated with bioavailable menthol doses and different parameters (lipid accumulation, “browning/brite” and energy expenditure gene expression, metal analysis, mitochondrial complex’s gene expression) were studied. No difference was observed in serum levels but significant difference was seen in the menthol concentration on subcutaneous adipose tissues after oral and topical application. Menthol administration at bioavailable doses significantly increased “browning/brite” and energy expenditure phenotype, enhanced mitochondrial activity related gene expression, increased metal concentration but didn’t alter the lipid accumulation. Further, we used pharmacological antagonism based approach to study the TRPM8 involvement in menthol effect. In conclusion, the present study provides an evidence that bioavailable menthol after single oral and topical administration is sufficient to induce “brite” phenotype in subcutaneous adipose tissue.
Repetitive Transcranial Magnetic Stimulation of the Intraparietal Sulcuschanges the Grip Force Modulation Exerted by Manual Action-Verbs – An Exploratory Study
Authors: da Silva Ronaldo Luis , Frak Victor , Higgins Johanne
Published: January 2019

Objective: To evaluate the effects of left intraparietal sulcus (IPS) inhibition by repetitive transcranial magnetic stimulation (rTMS) on grip force modulation (GFM) for both hands during a unimanual task. Methods: GFM induced by manual action-verb listening was evaluated for each hand in a unimanual task, and the motor-evoked potentials (MEP) were recorded for both left and right hemispheres prior to and following the left IPS inhibition. Left IPS inhibition was obtained by rTMS (5 min of 1.0 Hz, 60% of maximal stimulator output) of the international 10–20 system P3 point. Seven healthy right-handed subjects were evaluated. Results: One-way repeated measures ANOVA found that MEP amplitude and duration increased following IPS inhibition in the left hemisphere and did not change in the right hemisphere. Language-induced modulation did not change in the left hemisphere, while it was significantly attenuated in the right hemisphere. Since IPS inhibition increased the left primary motor cortex (M1) excitability, the maintenance of language-induced modulation intensity suggests it was also attenuated. Conclusion: Left IPS inhibition increased left M1 excitability without changing right M1 excitability, while attenuating the language-induced GFM for both the left and right hands.
Method of Generating Contexts based on Self-adaptive Differential Particle Swarm Using Local Topology for Multimodal Optimization in the Case of Multigranulation. A Case Study
Authors: Arias Dianne , Filiberto Yaima , Bello Rafael
Published: January 2019

Multigranulation is a new approach to the Rough Set Theory, where several separability relationships are used to obtain different granulations of the universe. The Multigranulation starts from the existence of different contexts or subsets of features to characterize the objects of the universe. In this paper, a method for the generation of contexts from the construction of similarity relations is proposed.The proposed solution was evaluated in an international database using the KNN classifier. It was also applied in the solution of a real problem in Civil Engineering specifically in Traffic Engineering, the contexts generated from the proposal used to determine the features of higher incidence in the service level of the road. The results achieved both in the international database and in the proposed application demonstrate the applicability of the proposed method.
Conjunctivitis and Exposure to Ambient Ozone
Authors: Szyszkowicz Mieczyslaw , Gordon Shaag Ariela , Shneor Einat
Published: January 2019

The purpose of this study is to assess the concentration-response relations between conjunctivitis and exposure to ambient ozone. This retrospective study includes emergency department (ED) visits for conjunctivitis in Edmonton, Canada, for the period April 1992 – March 2002. Daily average levels of ozone, of temperature and relative humidity were estimated and used for the period of the study. For each of the considered exposure lags, from 0 to 9 days, six various models were fitted to estimate the concentration-response function. The goodness of fit was assessed using Akaike information criterion. During the period of the study, 17,211 ED visits for conjunctivitis were recorded and used. For all subjects together, a positive statistically significant association was obtained for the exposure lagged by 5 days. For female subjects, lags 1, 3, and 9 had positive statistically significant associations (lag 2 had negative associations). For male subjects only lag 5 had a positive statistically significant association. The estimated non-linear concentration-response functions for the considered groups (all, males, females) and lags, revealed the associations along the exposure levels. The fitted shapes are described by the parameters and may have various forms. The estimated function are useful to determine the risk associated with exposure to ground-level ozone.
Big Data-Driven Market-Oriented Information System for the Internationalisation and Strategic and Sustainable Management of SMEs
Authors: Heo Yoseob , Kim Jungjoon , Kang Jongseok
Published: January 2019

There have been many discussions on the globalisation of SMEs, but it is true that there is not enough academic achievement after such the study of Born global (BG) ventures. The internationalisation of SMEs (Small and Medium Enterprises) is not easy because they lack resources or capabilities compared to multinational corporations. This study investigated the role of government in assisting the internationalisation of SMEs. In particular, SMEs lacked the ability to acquire market-oriented information, so we’ve established the scheme of efficient information support system for the internationalisation of SMEs. In other words, we proposed an information analysis system through the establishment of a relational database constructed for market-oriented information support. KISTI (Korea Institute of Science and Technology Information), which is one of the government-funded research institutes in the Republic of Korea, provided information support to the SMEs dealing with hydrazine related products. This study suggests this case for the market-oriented information support of the government in the internationalisation of SMEs. The research on information support of the government is meaningful in that it suggests a way to support SMEs in practical level.
Continuous Wavelet Transform of Schwartz Tempered Distributions in $S'(\mathbb R^n)$
Authors: Pandey Jagdish Narayan , Maurya Jay Singh , Upadhyay Santosh Kumar , Srivastava Hari Mohan
Published: January 2019

In this paper we define a continuous wavelet transform of a Schwartz tempered distribution $f \in S^{'}(\mathbb R^n)$ with wavelet kernel $\psi \in S(\mathbb R^n)$ and derive the corresponding wavelet inversion formula interpreting convergence in the weak topology of $S^{'}(\mathbb R^n)$. It turns out that the wavelet transform of a constant distribution is zero and our wavelet inversion formula is not true for constant distribution, but it is true for a non-constant distribution which is not equal to the sum of a non-constant distribution with a non-zero constant distribution.
Isolation and Characterisation of Bacteriophages with Lytic Activity Against Virulent Escherichia coli O157:H7: Potential Bio-Control Agents
Authors: Ateba Collins Njie , Akindolire Muyiwa Ajoke
Published: January 2019

Bacteriophages can provide alternative measures for the control of E. coli O157:H7 that is currently an emerging food-borne pathogen of severe public health concern. This study was aimed at characterising E. coli O157:H7 specific phages as potential biocontrol agents for these pathogens. Fifteen phages were isolated and screened against 69 environmental E. coli O157:H7. Only 3 phages displayed broad lytic spectra against environmental shiga toxin-producing E. coli O157:H7 strains. These 3 lytic phages were designated V3, V7 and V8. Subsequent characterization indicated that they displayed very high degree of similarities despite isolation from different locations. Transmission Electron microscopy (TEM) of the phages revealed that they all had isometric heads of about 73 – 77 nm in diameter and short tails ranging from 20 - 25 nm in diameter. Phages V3, V7 and V8 were assigned to the family Podoviridae based on their morphology. Pulsed field gel electrophoresis (PFGE) genome estimation of the 3 phages demonstrated identical genome sizes of ~ 69 nm. The latent periods of these phages were 20 min, 15 min, and 20 min for V3, V7 and V8 respectively while the burst sizes were 374, 349 and 419 PFU/ infected cell respectively. While all the phages were relatively stable over a wide range of salinity, temperatures and pH values, their range of infectivity or lytic profile was rather narrow on environmental E. coli O157:H7 strains isolated from cattle faeces. This study showed that the Podoviridae bacteriophages are the dominant E. coli O57:H7-infecting phages harboured in cattle faeces in the North-West Province of South Africa and due to their favourable characteristics can be exploited in the formulation of phage cocktails for the bio-control of E. coli O157:H7 in meat and other meat products.
Advances in Early Detection of Pancreatic Cancer
Authors: Kanno Atsushi , Masamune Atsushi , Hanada Keiji , Kikuyama Masataka , Kitano Masayuki
Published: January 2019

Early detection of pancreatic ductal adenocarcinoma (PDAC) requires further examination after selecting cases with risk factors for the condition, such as family history, hereditary pancreatic carcinoma syndrome, intraductal papillary mucinous neoplasms, or chronic pancreatitis. The Japan Study Group on the Early Detection of Pancreatic Cancer has investigated and clarified the clinicopathological features for the early diagnosis of PDAC. Further approaches for the early diagnosis of PDAC are warranted.
Low Temperature and Low UV Index Correlate with Peaks of Influenza Virus Activity in Northern Europe during 2010-2018
Authors: Ianevski Aleksandr , Zusinaite Eva , Shtaida Nastassia , Kallio-Kokko Hannumari , Valkonen Miia , Kantele Anu , Telling Kaidi , Lutsar Irja , Letjuka Pille , Metelitsa Natalja , Oksenych Valentyn , Dumpis Uga , Vitkauskiene Astra , Stašaitis Kestutis , Öhrmalm Christina , Bondeson Kåre , Bergqvist Anders , Cox Rebecca , Tenson Tanel , Merits Andres , Kainov Denis
Published: January 2019

With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, wind speed, atmospheric pressure, and precipitation on IV activity in Norway, Sweden, Finland, Estonia, Latvia and Lithuania during 2010-2018. Both correlation and machine learning analyses revealed that low temperature and low UV indexes were the most predictive meteorological factors for IV epidemics in the Northern European countries. Our in vitro experiments confirmed that low temperature and UV radiation preserved IV infectivity. Associations between these meteorological factors and IV activity could improve surveillance and promote development of accurate predictive models for future influenza outbreaks in Northern Europe.
Equitability in Healthcare Resource Allocation Concerning Substance Users: An Argument Against Lower Priority Setting
Authors: Carroll La Shun L.
Published: January 2019

Organ transplantation centers set criteria for candidate qualification, which has led to disparate healthcare resource allocation practices affecting those with a substance use history. These individuals are denied organ transplants by committees and healthcare providers who assign them lower priority status. The lower priority argument claims that healthcare resources should not be provided equally to individuals failing to share responsibility for not doing enough in addressing the diseases associated with substance use. The purpose of this work is to explore the interrelatedness between the ethics of a merit-based system of moral responsibility and lower priority setting involved in healthcare resource allocation pertaining to those with substance use histories.  An integral approach to the argument against the lower prioritists with a focus on the relationship between different organ allocation practices affecting substance users and the justification for resource allocation practices in healthcare and transplant committees. Lower priority setting is challenged, and an argument offered in which substance users are assigned higher priority when relying on “doing enough” in a merit-based system of moral responsibility. It is determined that one cannot substantiate assigning a lower priority status since a lack of success in rehab does not imply a lack of effort.  Additionally, neither to confirmatory behavior, nor to non-conforming behavior may freedom be justifiably ascribed in a merit-based system of responsibility because freedom to choose can neither be established a priori, nor a posteriori with respect to meritorious behavior.
Program Penerapan Teknologi Tepat Guna Implementasi ASTER (Alat Silase Terkompartemen) untuk Peternak Domba di Wilayah Kadudampit Kabupaten Sukabumi
Authors: Suhendar Suhendar
Published: January 2019

Abstract

The application of Appropriate Technology to the Community was carried out in Kadudampit District, Sukabumi Regency, West Java Province. As the sub-district mapped to be one of the centers of sheep farmers by the Sukabumi Regency government, the farmers have problems with the availability of fresh forage which is limited during the dry season. They also do not have the ability to make silage and design silage tools that are truly effective and efficient. The aim of this program is to provide information and skills to the sheep breeders group about silage feed technology, design and use of the Compartment Silage Tool (ASTER). This program is carried out through seven stages, including: 1) Activity Socialization; 2) Design of the Compartment Silage Tool Implementation; 3) Assembling the Compartment Silage Tool; 4) Compartment Silage Tool Operation Test; 5) Operational Assistance and Completion of the Compartment Silage Tool; 6) Application and grant of Compartment Silage Tool; and 7) the monitoring and evaluation stage, aims to see the progress and achievements of each stage of the program so that all programs can be carried out according to the objectives.

 

Abstrak

Penerapan Teknologi Tepat Guna Kepada Masyarakat ini dilakukan di Kecamatan Kadudampit, Kabupaten Sukabumi Provinsi Jawa Barat. Sebagai kecamatan yang dipetakan menjadi salah satu sentra peternak domba oleh pemerintah Kabupaten Sukabumi, para peternaknya memiliki masalah akan ketersediaan pakan hijauan segar yang terbatas pada saat musim kemarau. Mereka juga tidak memiliki kemampuan membuat silase serta merancang alat silase yang benar-benar efektif dan efisien. Tujuan dari program Penerapan Teknologi Tepat Guna Kepada Masyarakat ini adalah memberikan sosialisasi dan keterampilan kepada kelompok peternak domba tentang teknologi pakan silase, perancangan dan penggunaan Alat Silase Terkompartemen (ASTER). Program ini dilakukan melalui tujuh tahap, antara lain: 1) Sosialisasi Kegiatan; 2) Perancangan Implementasi Alat Silase Terkompartemen; 3) Perakitan Alat Silase Terkompartemen; 4) Uji Operasi Alat Silase Terkompartemen; 5) Pendampingan Operasional dan Penyempurnaan Alat Silase Terkompartemen; 6) Penerapan dan menghibahkan Alat Silase Terkompartemen;  dan 7) tahap monitoring dan evaluasi, bertujuan melihat progres dan capaian setiap tahapan program ini agar seluruh program dapat terlaksana sesuai tujuan.
Development and Evaluation of Coconut Flakes
Authors: Haritha T. , Thilakavathy S.
Published: January 2019

Cocos nucifera L. (Family Arecaceae) commonly known as coconut, is an important fruit crop in the tropical countries.The objective of this study was to develop coconut chips with different flavours from tall, dwarf and breed varieties of coconut and to evaluate organoleptically. Also nutrient analysis of three varieties of coconut was carried out followed by the shelf life study of coconut chips. Three varieties of coconut were selected namely tall, dwarf and breed. Plain, sweet and spicy coconut chips were prepared from these three varieties and it was compared with that of the standard namely conventional traditional variety of coconut. Traditional variety is most suitable for making plain coconut chips with white pepper flavour (PSV1) followed by dwarf, tall and breed varieties of coconut. Mean acceptability score of sweet coconut chips- osmotic dehydration method (SwSV1) revealed that traditional variety was good followed by dwarf, tall and breed varieties of coconut. Sweet coconut chips prepared without osmotic dehydration method traditional variety was good followed by tall, dwarf and breed varieties of coconut. Traditional variety of coconut chips was good for making spicy coconut chips- white pepper flavour (SpSV1) followed by breed, dwarf and tall varieties of coconut. Spicy coconut chips- chilli powder (SpMV2), traditional variety of coconut chips was good followed by dwarf, breed and tall varieties of coconut
Selective Extraction of Surface-active and Antioxidant Hydrolysates from Yellowfin Tuna Red Meat Protein using Papain by Response Surface Methodology
Authors: Unnikrishnan Parvathy , Kizhakkethil Binsi Puthenveetil , Annamalai Jeyakumari , George Joshy Chalil , Zynudheen Aliyamveetil Abubacker , Ninan George , Ravishankar Chandragiri Nagarajarao
Published: January 2019

The present study was focused on the selective extraction of surface-active and antioxidant hydrolysates from yellowfin tuna (Thunnus albacares) red meat based on separate hydrolytic conditions using papain. The effect of key processing variables viz., enzymesubstrate ratio (0.25-1.5 %) and hydrolysis time (30-240 min) under optimized temperature and pH, on the protein recovery, surface-active and antioxidative properties, was determined using Response Surface Methodology (RSM) with a central composite design. Single and combined effects of the variables on the responses were studied by formulating 13 experimental runs. The coefficient of determination (R2) ranged between 0.73 – 0.99 indicating the suitability of the fitted regression models. The optimum hydrolytic conditions to get hydrolysates having superior surface-active properties were enzyme-substrate ratio (E/S) of 0.41 % and 30 minutes hydrolysis time with a desirability of 0.611. Similarly, the optimum conditions to exhibit the highest antioxidative properties with a desirability of 0.932 were: 1.28 % E/S and 240 minutes hydrolysis time.
Effect of Pre-Treatments and Drying Air Temperature on the Quality of Dehydrated Oyster Mushroom (Pleurotus Florida)
Authors: Bora Parul , Kawatra Asha
Published: January 2019

Experiments were conducted on pre treated dehydrated oyster mushroom with steeping in citric acid and sodium chloride and blanching to investigate the effect of pre treatments and drying methods on drying characteristics of mushroom and quality of dried oyster mushroom. Drying was accomplished in a cabinet dryer using hot air at 40O C, 60OC and by sun drying. The drying characteristics of mushroom were not affected by the pre-treatments significantly. However, the rate of drying increased with the increase in drying temperature. Increase in drying temperature significantly reduced the total drying time. Pre treatments and drying temperature had adverse influence on the rehydration ratio, hardness and colour of the dehydrated mushrooms. Blanching improves the colour of the dehydrated mushroom but increased hardness also. A loss of protein was observed during blanching
Imaging in Endocrine Disorders
Authors: Sarasvathi V.
Published: January 2019

No Abstract.
Quality assessment of sprouted mung beans at various storage temperatures
Authors: Prabha Shashi , Goomer Sangeeta
Published: January 2019

The present study was conducted with an objective to assess the quality of sprouted mung beans stored at different temperatures. Mung beans sprouts were processed at laboratory in controlled conditions, packed in LDPE pouches and were stored at summer room temperature (SRT) (30-32°C), winter room temperature (WRT) (15-18°C) and refrigeration temperature (RT) (7°C). Shelf life studies were conducted periodically for physical, chemical and microbiological parameters for 5 days at their respective storage temperatures. During shelf life studies, several changes were observed in sprouted samples of mung beans. There was a significant (p<0.05) increase in shoot length of sprouted mung beans samples stored at SRT followed by WRT and RT. Decrease in moisture content was significantly (p<0.05) more at RT followed by WRT and SRT. Vitamin - C content increased significantly (p<0.05) up to 1st day of storage at SRT and WRT, with decrease thereafter. Whereas at RT significant (p<0.05) increase was observed till 2nd day of storage followed by decrease afterwards. Vitamin - C content retained better at RT (16.6%) followed by WRT (6.3 %), while at SRT loss of 6.9% was observed. Acidity increased significantly at all three storage temperatures followed by subsequent decrease. Microbial count in terms of total plate count, yeast and mold count was comparatively higher at SRT followed by WRT and RT, though within acceptable range, whereas Coliform count was not detected at any stage. Thus it can be concluded that at RT (7°C) within two days of storage, optimal retention of physicochemical and microbiological qualities are achieved.
Raza y ley en “Cecilia Valdés”, de Cirilo Villaverde
Authors: González Echevarría Roberto
Published: January 2019

A relação entre o Direito e a ficção narrativa remete à sua compartilhada origem comum na retórica e, na moderna América Latina, a um passado derivado da Espanha, que se inicia com as Siete partidas, de Alfonso, o Sábio, a Recopilación de leyes de Indias, de 1681, e a proclamação de constituições pelas novas repúblicas após a independência no começo do século XIX. A mais significativa delas foi a constituição espanhola, de Cádiz, em 1812. A isso se soma o fato de que muitos escritores latino-americanos foram advogados ou, então, estudaram Direito. Cecilia Valdés, romance publicado por Cirilo Villaverde, um escritor cubano, independentista e abolicionista, exilado em Nova York, em 1882. Trata-se de um romance histórico que se concentra nas relações raciais em Cuba durante a escravidão, girando em torno de uma família composta por um pai espanhol, Cándido, sua esposa e filhos cubanos, entre eles Cecilia, uma mulata clara, que parece branca. O conflito principal do romance, para além do contexto global da escravidão e do colonialismo espanhol, envolve a relação amorosa entre Cecilia e Leonardo, o filho de Cándido, que não sabem serem irmãos. Uma trama melodramática conduz ao matrimônio de ambos e ao assassinato de Leonardo por Pimienta, um músico mulato apaixonado por Cecilia.
O direito à fertilização “in vitro” no Brasil: análise jurídico-literária à luz da obra “Admirável mundo novo”
Authors: Sarlet Gabrielle Bezerra Sales
Published: January 2019

Consiste em análise jurídico-literária do contexto atual brasileiro para o exercício dos direitos reprodutivos e, em especial, do direito à fertilização in vitro, reconhecido pela Corte Interamericana no emblemático caso Artavia Murillo, para evidenciar a indissociabilidade da teoria e da prática, principalmente no que concerne à esfera dos direitos e das garantias nos âmbitos interno e internacional global de proteção sob o enfoque da obra Admirável mundo novo, do teor da última resolução do CFM - Conselho Federal de Medicina sobre o tema e das normas que compõem o sistema protetivo de modo geral que afetam diretamente à autonomia reprodutiva por meio de pesquisa teórica, bibliográfica e exploratória.
Common problems with current industry standard patient monitoring: a mixed qualitative and quantitative study
Authors: Tscholl David , Handschin Lucas , Rössler Julian , Weiss Mona , Spahn Donat R. , Nöthiger Christoph B.
Published: January 2019

BACKGROUND: Patient monitoring ensures the safety of patients in perioperative, intensive care and emergency medicine. There are some well-studied issues, such as alarm fatigue and information presentation. For this study, we use a mixed qualitative and quantitative approach to get a global feel for the problems of users with today's state of the art patient monitoring.
METHODS: First, we conducted interviews with 120 anesthesiologists (physicians and nurses) asking them about problems they experience with patient monitors. We then coded the answers into topics and subtopics that we present and discuss. In a second study, a field survey with 25 anesthesiologists, we added a quantitative part in which anesthesiologists rated their agree- or disagreement with statements based on the themes identified in the prior analysis on a five-step ordinal rating scale.
RESULTS: We have identified the following six main topics: 1. "Alarms," 2. "Artifacts," 3. "Software," 4. "Hardware," 5. "Human Factors," 6. "System Factors," and a total of 17 sub-topics. The quantitative statements raised for each major theme were: 1. “problems with alarm settings complicate the work with patient monitoring.” (96% agreed) 2. “artifacts complicate the assessment of the patient's condition.” (56% agreed) 3. “information overload makes it difficult to get a quick overview of the situation.” (56% agreed) 4. “problems with cables make working with patient monitors tedious.” (88% agreed) 5. “factors related to human performance lead to patient conditions not being perceived on the monitor.” (64% agreed) 6. “Insufficient standardization: Switching back and forth between monitors from different manufacturers makes it difficult to work with patient monitors.” (88% agreed). Non-parametric testing determined all six statements to differ significantly from the neutral opinion.
CONCLUSION: This study provides an overview of the problems users face in their work with patient monitoring. The most annoying issues identified were related to alarms, cables and insufficient standardization between different manufacturers. An ideal monitor should, therefore, have an alarm system that reduces false positive alarms to a minimum, works with as few cables as possible and is easy to learn. This paper shows that there is still much room for improvement in patient monitoring systems.
Educational hypogamy and second births in Hungary
Authors: Bartus Tamás
Published: January 2019

Recently, a growing body of literature examined the implications of the reversal of gender gap in education end educational hypogamy for family  formation. However, less is known about the effect of educational  hypogamy on second birth rates. In the present paper, we examine the effect of educational hypogamy on second birth rates in Hungary. Drawing on the economic theory of fertility and available data on sex- and education-specific average wages, we hypothesize that (1) educational hypogamy has a negative effect on second birth rates, and (2) the magnitude of that effect increases with female education. The hypotheses are tested using event history data from the first four waves of the Hungarian Generations and Gender Survey. The analyses are restricted to women born 1951-1980 who were partnered at the time of first birth. We find that educational hypogamy decreases second birth rates, especially among women born between 1971 and 1980. However, we do not find evidence which would support the second hypothesis. Rather, the effect of hypogamy is the largest among women with secondary education, but only in the 1971-1980 cohort. The findings may explain the U-shaped relationship between education and second birth rates.
Metabolism of Rhaponticin and Activities of its Metabolite, Rhapontigenin: A Review
Authors: Chen Dan , Liu Jing-Ru , Cheng Yanjin , Cheng Hua , He Ping , Sun Yang
Published: January 2019

Rhaponticin is a stilbenoid glucoside compound, found in medicinal plant of rhubarb
rhizomes. Rhapontigenin (RHAG), the stilbene aglycone metabolite of rhaponticin, has
shown various biological activities including anticancer activities to act a potential human cytochrome
P450 inhibitor, antihyperlipidemic effect, anti-allergic action, antioxidant and antibacterial
activities. Moreover, it was reported to scavenge intracellular Reactive Oxygen Species
(ROS), the 1,1-Diphenyl-2-Picrylliydrazyl (DPPH) radical, and Hydrogen Peroxide
(H2O2). Meanwhile, RHAG exhibited the inhibitory activity for the synthesis of DNA, RNA
and protein, and also presented the capacity of inducing morphological changes and apoptosis
of C. albicans. Here, the structure, pharmacokinetics, pharmacological effects as well as underlying
mechanisms of rhaponticin and its metabolite, RHAG, have been extensively reviewed.
This review will provide a certain reference value for developing the therapeutic drug
of rhaponticin or RHAG.
Integrative Analysis of Dysfunctional Modules Driven by Genomic Alterations at System Level Across 11 Cancer Types
Authors: Wang Yin , Liu Zhenhao , Lian Baofeng , Liu Lei , Xie Lu
Published: January 2019

Aim and Objective:

Integrating multi-omics data to identify driver genes and key biological functions for tumorigenesis remains a major challenge.

Method:

A new computational pipeline was developed to identify the Driver Mutation-Differential Co-Expression (DM-DCE) modules based on dysfunctional networks across 11 TCGA cancers.

Results:

Functional analyses provided insight into the properties of various cancers, and found common cellular signals / pathways of cancers. Furthermore, the corresponding network analysis identified conservations or interactions across different types of cancers, thus the crosstalk between the key signaling pathways, immunity and cancers was found. Clinical analysis also identified key prognostic / survival patterns.

Conclusion:

Taken together, our study sheds light on both cancer-specific and cross-cancer characteristics systematically.
Patients Presenting with a Hot, Swollen Joint: A Single-Centre Retrospective Analysis
Authors: Chisari Emanuele , Yaghmour Khaled M. , Peat Fidel , Khan Wasim
Published: January 2019

Background:

A hot, swollen joint is a common clinical condition encountered in the ED
and elective orthopaedic and rheumatology clinics. These patients can be difficult to manage and
properly treat.

Aims and Objectives:

The aim of this study was to report a single centre retrospective analysis of
patients presenting to our institution for a hot, swollen joint over a three-month period.

Methods:

The study included patients presenting with a hot, swollen joint to ED or electively to
clinics. The synovial fluid was aspirated and sent for microbiological and cytological investigation.
P value was set to < 0.001. 36 patients (22 M, 14 F) with a mean age of 72.8 ± 17.4 years met our
criteria. 20 cases (55.6 %) involved the knee joint, the wrist in 10 cases (27.8%), the elbow in 3
cases (8.3%) and the shoulder in 3 cases (8.3%).

Results:

Of the 36 synovial fluid samples collected, only 7 (19.4%) reported evidence of infection.
On cytological examination of the synovial fluid, 21 (58.3%) reported presence of calcium pyrophosphates
crystals (Pseudogout), 4 (11.1 %) reported presence of uric acid crystals (Gout) and 11
(30.5%) reported absence of crystals. We found a significant correlation between age and the diagnosis
of pseudogout and between previous antibiotic treatment and ED presentation. Our study
sheds light on the high incidence of crystal-related pathologies.

Conclusion:

In order to improve our management of this common condition and enhance our understanding
of the clinical diagnosis in certain patient population, further high-profile clinical studies
are needed.