bluuebunny/crossref_metadata_2025 huggingface dataset:
Measuring Behavior Problems in Children from Low-Income Families: A Rasch Analysis of the Child Behavior Checklist for Ages 1½–5
Authors: Hsiao Yu-Yu , Qi Cathy Huaqing , Dale Philip S. , Bulotsky-Shearer Rebecca , Wang Qing
Published: March 2023

The Child Behavior Checklist for Ages 1.5–5 (CBCL/1½ –5) has been widely used by researchers and clinicians in the field of special education and psychology. The purpose of this study was to examine the psychometric properties of the CBCL/1½-5 with a sample of preschool children from low-income families using the Rasch model. Participants included 244 children enrolled in a Head Start program. Findings suggested that both the Internalizing and Externalizing subscales are unidimensional and demonstrated local independence successfully, after misfit items were removed to fit the Rasch model. Both subscales operated well with high item reliability and low to medium person reliability, indicating that both subscales have stable item difficulty orders from sample to sample but weaker capacity to distinguish children with mild problem behaviors from those with more severe problems. Differential item functioning was found for a few items across child gender. Considering the length of the item sets, it is appropriate to use the subscale scores to compare the differences in problem behaviors between boys and girls. Overall, the CBCL/1½ –5 has adequate psychometric properties for detecting problem behaviors in preschool children from low-income families. Implications were discussed.
Pharmacy Intern Involvement in COVID-19 Immunization Practices in New York State
Authors: Shtaynberg Jane , Gim Suzanna , Cope Rebecca , Maddox Katherine , DelMonte Keith , Tackes Courtney C. , O’Brocta Richard F.
Published: March 2023

Background: Pharmacists and pharmacy interns were instrumental in vaccination efforts during the COVID-19 pandemic. Objectives: To identify pharmacy intern involvement in COVID-19 immunization practices in New York State (NYS) and explore interns’ perceptions of experiences. Methods: A 34-item survey was developed and administered at 5 pharmacy programs in NYS. Data collected included: perceptions of immunization readiness, participation in immunizations, description of experiences, and perceptions on the role of pharmacists. Respondents also reported on their preparedness to participate in the immunization process and the types of questions received from patients. Data were analyzed using descriptive statistics and thematic analysis. Questions regarding student experiences before and after participating in immunization efforts were analyzed using a two-sample t test. Results: A total of 460 interns participated in the survey with 398 (87%) reporting participation in COVID-19 immunizations. Of those, 231 (58%) participated at work, 146 (36.7) during experiential rotations, and 98 (24.6%) during volunteer experiences. Respondents participated in various components of vaccine delivery including administration ( n = 246, 61.8%). Respondents administered an estimated 57,100 COVID-19 vaccines from December 2020 to April 2021 resulting in significantly higher mean scores for comfort level (5-point Likert scale) administering vaccines after participation (mean score 4.08 ± 1.31) compared to before (mean score 3.61 ± 1.42) ( p < .0001). Themes which emerged regarding student perceptions of their experience are described. Conclusion: Pharmacy intern involvement in NYS COVID-19 immunization practices contributed to public health vaccination efforts. Additionally, interns improved comfort levels with immunization administration and recognized pharmacists’ emerging roles within the U.S. healthcare system.
The intersectionality of health (in)security: Healthcare, disposable workers, and exposure within Brazil’s pandemic politics
Authors: Pérez José O , Mendes Vinícius
Published: March 2023

Brazil has suffered severe consequences from the Covid-19 pandemic, currently ranking second globally in terms of total fatalities, with more than 682,000 lives lost. This article critically outlines how a ‘health security’ framework overlooks processes of intersectionality and the varying impacts of the virus on different segments of society, or what we term health insecurity. We organize our analysis around three aspects of the pandemic that have become salient in Brazilian society, namely access to healthcare, disposable workers, and exposure to the virus, and delineate the intersectional impact of gendered inequality, neoliberal ideologies, and racial hierarchies within these three themes. Our methodology employs media and scholarly interpretations of Covid-19, and other secondary empirical and statistical data, to outline the virus’s impacts on differently positioned bodies throughout Brazilian society. Our main findings reveal that during the pandemic, women’s labor and health concerns have been undervalued, exploitative working conditions have been exacerbated, and Afro-Brazilians have been put in situations of higher exposure to the virus in both public and private spaces. This article underscores the need to better examine how public health, systems of oppression and exclusion, and (in)security overlap with each other.
Dating App Communication: Personal Characteristics, Motives and Behavioural Intent
Authors: Cruz J. J. De La , Punyanunt-Carter Narissra Maria , Wrench Jason S.
Published: March 2023

Guided by the uses and gratifications theory ( Katz et al., 1973 ) and the goals-planning-action model of interpersonal influence ( Dillard, 1990 ), two studies are presented to examine aspects of Dating app communication. Study 1 ( N = 526) investigates proximal relations between a personality trait and motives and motives and behavioural intent. Study 2 ( N = 200) further probes elements of study 1 in a new sample and investigates new personality traits to motives. Collectively, these studies provide an initial look at and explain the relations between personality traits, motives and behavioural intent, which advance understanding of Dating app use from an interpersonal communication perspective. Implications, limitations and future directions are also discussed.
Corporate social responsibility as management idea: Between universal applicability and context dependency
Authors: Preuss Lutz
Published: March 2023

The international spread of the concept of corporate social responsibility (CSR) has ignited a debate whether CSR is universally applicable or context dependent. To shed new light on this question, I propose to treat CSR as a management idea that consists of nested levels of abstraction, namely relatively abstract ‘management rhetorics’, within which more prescriptive ‘management models’ reside, which contain concrete ‘management techniques’. I then analyse the global diffusion of one CSR management technique, a CSR guidance document by UK-based business association Business in the Community (BITC), which suggests that companies could address CSR as four material areas: Workplace, Environment, Marketplace and Community. Following its life-cycle through the innovation, diffusion, institutionalization, dormancy and rebirth stages allows me to identify forms of horizontal diffusion, that is, diffusion among peers within a particular sector or country, and vertical diffusion, that is, between organizations that stand in a hierarchical relationship to each other. At each stage of the life-cycle, the success of the management technique seems to be aided by factors that treat the management technique as universally applicable. In themselves, all of these claims to universal applicability are easily countered by a more critical reading of the argumentation; yet, it is the way in which the nested levels influence each other, that is, the management technique feeding into management models and management rhetorics, that tends to give the notion of universal applicability of CSR its persuasiveness.
A retrospective study of pigeon herpesviral infection in domestic pigeons in California (1991–2014) and literature review
Authors: Gornatti-Churria Carlos Daniel , Loukopoulos Panayiotis , Stoute Simone T. , Shivaprasad H. L. , Uzal Francisco A.
Published: March 2023

We characterized naturally occurring pigeon herpesvirus (PiHV; Columbid alphaherpesvirus 1) infection in domestic pigeons in California. We retrieved and analyzed 62 pathology reports produced between 1991 and 2014 at the California Animal Health and Food Safety Laboratory System. In 56 of the cases, the diagnosis of PiHV infection was established based on histopathology, either alone (44 cases) or combined with virus isolation (VI; 8), transmission electron microscopy (TEM; 3), or PCR (1); in the remaining 6 cases, the diagnosis was established based on VI (5 cases) or TEM (1) alone. PiHV infection affected 1 system in 34, 2 in 16, and ≥3 systems in 6 cases; data were not available for the remaining 6 cases. Most commonly affected was the digestive system (55 cases), followed by the respiratory tract (5) and lymphoid system (2). The liver (39 cases), crop (17), and esophagus (14) were the organs affected most commonly. Many affected cells often bore single eosinophilic intranuclear inclusion bodies. PiHV infection was a secondary diagnosis or incidental finding in 35 cases. Most (55) cases had 1 (21), or up to 4 (34), other concurrent infections; the most common concurrent infections were pigeon circoviral infection (26), trichomonosis (24), aspergillosis (11), and colibacillosis (10).
Motivational Factors for Undergraduate Students During COVID-19 Remote Learning
Authors: Lopez Ruben M. , Tadros Eman
Published: March 2023

Pedagogical practices use support of empirical research conducted on students learning in-person, but traditional methods of teaching might not work in times of rapid changes. Globally, courses have switched to online/remote learning and the transition has created challenges to student achievement. The unexpected public safety hazards shifted research focus on the impact of remote learning during COVID-19. Previous interventions including positive reinforcement, negative punishment, perceived control, optimism, and factors of self-determination as single constructs have been used to increase student motivation and engagement. The literature reviewed provides an overview of the impact of previous motivation interventions and the theories used to examine students’ motivation. Future implications to design courses incorporating these key five focuses are ideal for student achievement in remote learning.
Critical Qualitative Inquiry: Examining the Influence of Changing Voices and Bodies on Legislative Spaces
Authors: Martínez Magdalena
Published: March 2023

Gender, race, and ethnic demographics have shifted and emergent policymakers are entering state legislatures. My work seeks to extend the role of critical qualitative research by examining emergent policymaking spaces and the new actors. I illustrate how praxis is witnessed in action in policymaking spaces to create change. I propose critical methodologies can be used as analytic anchors to offer an understanding on how progressive policymakers resist and succeed in policymaking spaces. Critical qualitative methodologies offer ways to explore spaces of praxis, insider/outsider in policymaking spaces, critical consciousness, and actors’ policy ways of knowing.
Introduction to Special Issue—Qualitative Inquiry in the 20/20s: Exploring Methodological Consequences of Digital Research Workflows
Authors: Lester Jessica Nina , Paulus Trena
Published: March 2023

This article offers an overview of a special issue that focuses on the reciprocal relationship between the digital tools and spaces that we use and the methodologies and methods that we take up in designing and carrying out a qualitative research study. In this editorial, we situate the special issue in the methodological literature around technologies and qualitative inquiry. We also provide an overview of the seven included articles, noting how each article offers new perspectives on the consequences of adopting digital research workflows.
Trauma of the Shared Environment: A Qualitative Analysis of the Experiences of Survivors of College Campus Sexual Assault
Authors: Coates Quezada C. Austin , Armstrong Laura , Kilmer Ryan , Quinlan Margaret , Reeve Charlie
Published: March 2023

Survivors of campus sexual assault are often tasked with healing while sharing an environment with their perpetrators. However, little is known about the effects of a shared environment on survivor well-being. A qualitative thematic analysis design was employed to address this gap. We conducted semi-structured interviews with nine female survivors who identified their perpetrators as fellow students at a large state university in the southeastern U.S. The five themes that emerged are situated within an ecological framework, which is also used to guide our recommendations for supporting survivors’ well-being within higher education.
Relationships Between Early Maladaptive Schemas and Emotional States in Individuals With Sexual Convictions
Authors: Vos Marije Keulen-de , Giesbers Geertje , Hülsken Julia
Published: March 2023

This study seeks to add to the existing knowledge and available literature on schema therapy elements in forensic inpatient samples. Early maladaptive schemas and emotional states were assessed in Dutch individuals with sexual convictions and compared to individuals with nonsexual violent convictions. Self-ratings of the Young Schema Questionnaire and the Schema Mode Inventory of 95 patients with either convictions for child sexual abuse ( N = 30), sexual violence against adults ( N = 34), and nonsexual violent convictions ( N = 31) were examined using one-way multivariate ANOVAs. Regardless of victim type, forensic patients convicted for sexual offending, and patients with convictions for nonsexual violent offending, seem to make equal use of specific maladaptive cognitive schemas and schema modes during mandated inpatient care. Other studies have shown that people with sexual offense histories are typically characterized by insecure attachment, overvigilance towards women, or a child-like self-concept. Our study indicates that forensic patient in Dutch mandated care may be qualitatively different from typical patients with sexual offense histories and that Dutch patients with violent or sexual offense histories are more similar than they are dissimilar.
Randomised, prospective, blinded, clinical trial of opioid-free injectable anaesthesia with or without multimodal analgesia in kittens undergoing ovariohysterectomy
Authors: Malo Annie , Cheng Alice J , Ruel Hélène LM , Monteiro Beatriz P , Lutevele Nathanael , Marangoni Sabrine , Garbin Marta , Watanabe Ryota , Steagall Paulo V
Published: March 2023

Objectives

This study compared an opioid-free injectable anaesthetic protocol with or without multimodal analgesia in kittens undergoing ovariohysterectomy.

Methods

In this prospective, randomised, blinded, clinical trial, 29 healthy kittens (mean ± SD weight 1.55 ± 0.46 kg; aged 10 weeks to 6 months) were included. Anaesthesia was performed with an intramuscular injection of ketamine (4 mg/kg), dexmedetomidine (40 μg/kg) and midazolam (0.25 mg/kg). In the multimodal group (MMG), cats (n = 14) received meloxicam (0.1 mg/kg SC) and intraperitoneal bupivacaine 0.25% (2 mg/kg), whereas the same volume of saline was administered in the control group (CG; n = 15). Atipamezole (0.4 mg/kg IM) was given 15 mins after ovariohysterectomy. Postoperative pain was assessed using the UNESP-Botucatu multidimensional feline pain assessment scale – short form. Rescue analgesia (buprenorphine 0.02 mg/kg IM in MMG/CG and meloxicam 0.1 mg/kg SC in CG) was administered if pain scores were ⩾4/12. Soft food intake (after 2 and 60 mins) was evaluated at specific time points postoperatively. Statistical analyses were performed with linear models and post-hoc pairwise comparison with Benjamini–Hochberg corrections ( P <0.05).

Results

The prevalence of rescue analgesia was higher in the CG (n = 15/15) than the MMG (n = 1/14; P <0.001). Pain scores at 1 h, 2 h and 4 h postoperatively were higher in the CG (4.1 ± 2.8, 4.8 ± 3.0 and 5.3 ± 1.2, respectively) than in the MMG (1.6 ± 1.0, 1.1 ± 1.0 and 0.9 ± 0.8, respectively; P <0.001). Food intake (%) at 1 h postoperatively was higher in the MMG after 2 and 60 mins (10.4 ± 9 and 71.9 ± 29, respectively) than in the CG (1.4 ± 2 and 13.9 ± 7, respectively; P <0.001).

Conclusions and relevance

This opioid-free protocol using multimodal analgesia produced adequate postoperative pain relief, while almost eliminating the need for rescue analgesia in kittens undergoing ovariohysterectomy. Pain decreased food intake.
Management of infected arteriovenous grafts for haemodialysis: Outcomes and strategies using a novel objective scoring system
Authors: Chow Bing Jie , Chowdary Prashanth , Khurram Muhammad , Mohamed Ismail H
Published: March 2023

Background:

In haemodialysis patients with exhausted autogenous options, prosthetic arteriovenous grafts (AVGs) are frequently utilised as tertiary vascular access. However, the prosthetic nature of AVGs precipitates an increased risk of infection which may translate to excess morbidity and life-threatening complications. The current evidence remains divided on the optimal treatment strategy for arteriovenous graft infections (AVGi) with arguments for conservative management by antibiotics, salvaging with graft revision or total/subtotal excision. To address this gap, we assessed the outcomes of AVGi patients treated in our institution, developing an AVGi severity classification model and a proposed treatment algorithm to guide AVGi management.

Methods:

We conducted a single centre retrospective review of outcomes of patients with AVGi managed either by sole antibiotics therapy, graft revision or surgical excision between June 2016 and May 2021. Outcomes of AVGi patients across differing treatment groups were compared, including 1-year mortality, 6-month and 1-year functional vascular access. We also analysed the outcomes of tunnelled haemodialysis lines (THL), which were used as a temporary vascular access in several AVGi patients in our study.

Results:

A total of 34 AVGi patients were managed within that time frame and included in the study (5 conservatively management by antibiotics, 5 graft revisions and 24 surgical excision) with a mean age of 60.4 ± 14.4 years (67.6% males). Overall 1-year mortality was 14.7%. A 6-month functional vascular access status across the three groups stood at 60%, 60% and 10% while 1-year functional vascular access status was 60%, 75% and 42% respectively.

Conclusions:

When clinically appropriate, conservative management by antibiotics or salvage/graft revision can present as prudent AVGi treatment options. The adoption of our proposed severity classification system and treatment algorithm provides a more thorough objective assessment of the infection and helps guide the clinical decision-making process.
Shielding citizens? Understanding the impact of political advertisement transparency information
Authors: Dobber Tom , Kruikemeier Sanne , Helberger Natali , Goodman Ellen
Published: March 2023

Online targeted advertising leverages an information asymmetry between the advertiser and the recipient. Policymakers in the European Union and the United States aim to decrease this asymmetry by requiring information transparency information alongside political advertisements, in the hope of activating citizens’ persuasion knowledge. However, the proposed regulations all present different directions with regard to the required content of transparency information. Consequently, not all proposed interventions will be (equally) effective. Moreover, there is a chance that transparent information has additional consequences, such as increasing privacy concerns or decreasing advertising effectiveness. Using an online experiment (N = 1331), this study addresses these challenges and finds that two regulatory interventions (DSA and HAA) increase persuasion knowledge, while the chance of raising privacy concerns or lowering advertisement effectiveness is present but slim. Results suggest transparency information interventions have some promise, but at the same time underline the limitations of user-facing transparency interventions.
Feasibility and social rights
Authors: Richards Charlie
Published: March 2023

Social interactions and personal relationships are essential for a minimally good life, and rights to such things – social rights – have been increasingly acknowledged in the literature. The question as to what extent social rights are feasible – and properly qualify as rights – however, remains. Can individuals reliably provide each other with love and friendship after trying, for instance? At first glance, this claim seems counterintuitive. This paper argues, contrary to our pre-theoretic intuitions, that individuals can reliably provide each other with such relationships, rendering even “thick” social rights feasible. This conclusion challenges the assumption that such things cannot be reliably provided after trying, and suggests that a surprisingly wide class of social rights are feasible. Claiming relationships characterised by love or friendship as a matter of justice, therefore, is possible, and our theories of justice should appropriately widen to accommodate this fact where appropriate.
Three-Dimensional Printing to Guide Fenestrated/Branched TEVAR in Triple Aortic Arch Branch Reconstruction With a Curative Effect Analysis
Authors: Fu Dong-Sheng , Jin Yi , Zhao Zi-He , Wang Chao , Shi Ying-Huan , Zhou Ming-Jie , Zhao Jing-Xiong , Liu Chen , Qiao Tong , Liu Chang-Jian , Li Xiao-Qiang , Li Wen-Dong , Liu Zhao
Published: March 2023

Purpose:

To summarize experience with and the efficacy of fenestrated/branched thoracic endovascular repair (F/B-TEVAR) using physician-modified stent-grafts (PMSGs) under 3D printing guidance in triple aortic arch branch reconstruction.

Materials and Methods:

From February 2018 to April 2022, 14 cases of aortic arch aneurysms and 30 cases of aortic arch dissection (22 acute aortic arch dissection and 8 long-term aortic arch dissection)were treated by F/B-TEVAR in our department, including 34 males and 10 females, with an average age of 59.84 ± 11.72 years. Three aortic arch branches were affected in all patients. A 3D-printed model was made according to computed tomography angiography images and used to guide the fabrication of PMSGs. All patients were followed up.

Results:

A total of 132 branches were successfully reconstructed with no case of conversion to open surgery. The average operation time was 4.97 ± 1.40 hours, including a mean 44.05 ± 7.72 minutes for stent-graft customization, the mean postoperative hospitalization duration was 9.91 ± 4.47 days, the average intraoperative blood loss was 480.91 mL (100–2810 mL), and the mean postoperative intensive care unit monitoring duration was 1.02 days (0–5 days). No deaths occurred within 30 days of surgery. Postoperative neurological complications occurred in 1 case (2.3%), and retrograde type A dissection occurred in 1 case (2.3%).

Conclusion:

Compared with conventional surgery, triple aortic arch branch reconstruction under the guidance of 3D printing is a minimally invasive treatment method with the advantages of accurate positioning, rapid postoperative recovery, few complications, and reliable short- to mid-term effects.

Clinical Impact

At present the PMSG usually depend on imaging data and software calculation. With the guidance of 3D printing technology, image data could be transformed into 3D model, which has improved the accuracy of the positioning of the fenestrations. The diameter reduction technique and the internal mini cuff technique have made a complement to the slimed-down fenestration selection process and the low rate of endoleak. As reproducible study, our results may provide reference for TEVAR in different cases.
Therapeutic effects of kartogenin on temporomandibular joint injury by activating the TGF-β/SMAD pathway in rats
Authors: Zhao Chengzhi , Ye Li , Cao Zhiwei , Tan Xing , Cao Yubin , Pan Jian
Published: March 2023

Patients with temporomandibular dysfunction (TMD) usually suffer from pathology or malpositioning of the temporomandibular joint (TMJ) disk, leading to the degenerative lesion of condyles. Kartogenin can promote the repair of damaged cartilage. This study aimed to explore whether intra-articular injection of kartogenin could alleviate the TMJ injury induced by type II collagenase. We measured the head withdrawal threshold and found that kartogenin alleviated the pain around TMD induced by type II collagenase. We observed the morphology of the condylar surface and found that kartogenin protected the integration of the condylar surface. We analyzed the density of the subchondral bone and found that kartogenin minimized the damage of TMJ injury to the subchondral bone. We next explored the histological changes and found that kartogenin increased the thickness of the proliferative layer and more collagen formation in the superficial layer. Then, to further ensure whether kartogenin promotes cell proliferation in the condyle, we performed immunohistochemistry of proliferating cell nuclear antigen (PCNA). The ratio of PCNA-positive cells was significantly increased in the kartogenin group. Next, immunofluorescence of TGF-β1 and SMAD3 was performed to reveal that kartogenin activated the TGF-β/SMAD pathway in the proliferative layer. In conclusion, kartogenin may have a therapeutic effect on TMJ injury by promoting cell proliferation in cartilage and subchondral bone. Kartogenin may be promising as an intra-articular injection agent to treat TMD.
Machphrasis: Towards a Poetics of Video Games in Contemporary Literary Culture
Authors: Butterworth-Parr Francis
Published: March 2023

This article develops Kawika Guillermo's ‘machphrasis’ (2016) as a theoretical contribution to discourse considering the deployment of video games in contemporary literary culture. After presenting machphrasis’ academic stakes, I propose that machphrasis can give explanations for some techniques and images endemic to late 20th/21st century writing with regards to video games represented in prose. By appending Guillermo's conceptual work with three additions, I work towards a reproducible poetics of the video game in prose writing. I will show that machphrasis may be used to understand video games in literature as proxies for anticipated technologies, as discursive tools for reckoning with new subjectivities indebted to play, and as the means for generating new ideological positions for those who play games but are excluded from the normative ‘gamer’ group. This contribution prepares current academic discourse for a future literary landscape increasingly beholden to machphrastic themes, ambitions, and language.
Rejecting Choices: The Problematic Origins of Researcher-Defined Paradigms within Qualitative Research
Authors: Chafe Roger
Published: March 2023

Paradigms are often presented as a way of distinguishing various qualitative and experimental research approaches. But carefully tracing their adoption through the work of Egon Guba, we can see that the model of researcher-defined paradigms used within qualitative research also arose from the replacement of a more open conception of naturalistic inquiry (N/I); the anthropomorphizing of ideal research types; the inclusion of the subject matter in the characterization of different types of researchers; that it is the inclusion of the subject matter in Guba’s conception of a naturalistic inquirer that necessitates his appeal to philosophy (i.e., ontology and epistemology) as the basis for selecting methodology; and that by doing so Guba violates his own concerns about researchers choosing their methodology before considering their subject matter, something that he referred to as the law of the hammer. The adoption of researcher-defined paradigms also rejects the position that the appropriateness of a methodological approach, including N/I and qualitative approaches, is primarily determined by the subject matter and researcher’s objectives, something Patton has referred to as the paradigm of choices. This review of the origins of researcher-defined paradigms problematizes and defamiliarizes this core concept within some models of qualitative research. Given that Guba’s model and its appeal to philosophy as the basis for selecting methodology still underlies a fundamental division within conceptions of qualitative inquiry, reconsidering its development and potential alternatives will allow current researchers to better appreciate the model of qualitative research they choose to work under.
Can mindfulness-based stress reduction relieve depressive symptoms? A systematic review and meta-analysis
Authors: Ding Fengqin , Wu Jing , Zhang Yi
Published: March 2023

Mindfulness-based stress reduction (MBSR) is becoming more and more popular in treating depressive symptoms, but previous studies have come to different conclusions. This meta-analysis aimed to evaluate the effectiveness of MBSR in alleviating depressive symptoms. A systematic search was conducted across seven electronic databases: Scopus, Web of Science, Embase, the Cochrane Library, PubMed, PsycINFO, and Google Scholar. Meta-analytic methods were applied by using random-effect models. The quality was assessed with the Cochrane Handbook for Systematic Reviews of Interventions. Thirty-two randomized controlled trials (RCTs) and 37 independent effect sizes were eligible for the meta-analysis. The meta-analysis revealed that MBSR showed significant improvements on depressive symptoms compared to the control group, and the intervention effects were more significant for people with major depression disorder. However, neither cultural background nor sample origin had significant effects on the results of intervention. In addition, there was no publication bias in the meta-analysis, and the sensitivity analysis results indicated that the result was reliable. Findings suggests that MBSR can improve depressive symptoms, and future studies should consider the effects of different levels of depression to improve the intervention benefits of MBSR.
Risk factors of significant relapse and appropriate maintenance therapy strategy in SLE-associated immune thrombocytopenia
Authors: Li He-Jun , Zheng Yi-Qing , Chen Ling , Lin Shun-Ping , Zheng Xiang-Xiong
Published: March 2023

Background:

Systemic lupus erythematosus–associated immune thrombocytopenia (SLE-ITP) is characterized by relapse. The risk factors of relapse and appropriate maintenance therapy strategy deserve further exploration.

Objectives:

To determine the risk factors for relapse and appropriate maintenance therapy in significant SLE-ITP patients (a platelet count ⩽30 × 109/l) after the first complete response.

Design:

Retrospective cohort study using the medical records of 105 patients diagnosed as significant SLE-ITP in Fujian Medical University Union Hospital during December 2012 to March 2021. Patients were followed through a call for observations in January 2022.

Methods:

Data including demographics, initial clinical feature, induction and maintenance therapy, and outcome at the end of follow-up were analyzed. Risk factors for significant relapse were analyzed using multivariate logistic regression models. The cumulative hazard of significant relapse and the duration of response were estimated, and the differences in outcome between groups were compared using the Cox regression analysis.

Results:

A total of 65 significant SLE-ITP patients were eligible for the final analysis. Median [interquartile range (IQR)] follow-up duration and median [IQR] duration of response were 62.2 [41.0–79.6] months and 43.4 [20.3–68.7] months, respectively. After the first complete response, 19/65 (29.2%) had a significant relapse. Compared with sustained clinical remission (SCR) + sustained response (SR) group, significant relapse group had a higher proportion of discontinued patients (47.4% versus 8.7%, p = 0.001). Among the 13 discontinued patients, the duration of maintenance therapy of the patients in significant relapse group was significantly shorter than that of the patients in SCR + SR group (months, median [IQR], 43.1 [32.0–62.4] versus 12.0 [5.1–22.0], p = 0.009). Multivariate logistic regression analysis showed that drug withdrawal was an independent risk factor for significant relapse [odds ratio (OR) = 10.4, confidence interval (CI) 95% 2.2–47.8, p = 0.003]. There was no significant difference between glucocorticoids (GCs) + hydroxychloroquine (HCQ) group and GCs + HCQ + immunosuppressive agents (ISAs) group in significant relapse rate (26.7% versus 22.2%, p > 0.05). The two SR curves of GCs + HCQ and GCs + HCQ+ ISA group basically coincided by the Cox regression analysis, demonstrating comparable long-term outcomes ( p > 0.05).

Conclusion:

Drug withdrawal, especially abrupt withdrawal with insufficient duration of maintenance therapy, is an independent risk factor for significant relapse of SLE-ITP. HCQ combined with GCs is expected to be the first choice of the maintenance therapy for SLE-ITP patients.
Effects of forward mask duration variability on the temporal dynamics of brief facial expression categorization
Authors: Chamberland Justin A. , Collin Charles A.
Published: March 2023

The Japanese and Caucasian Brief Affect Recognition Task (JACBART) has been proposed as a standardized method for measuring people's ability to accurately categorize briefly presented images of facial expressions. However, the factors that impact performance in this task are not entirely understood. The current study sought to explore the role of the forward mask's duration (i.e., fixed vs. variable) in brief affect categorization across expressions of the six basic emotions (i.e., anger, disgust, fear, happiness, sadness, and surprise) and three presentation times (i.e., 17, 67, and 500 ms). Current findings do not demonstrate evidence that a variable duration forward mask negatively impacts brief affect categorization. However, efficiency and necessity thresholds were observed to vary across the expressions of emotion. Further exploration of the temporal dynamics of facial affect categorization will therefore require a consideration of these differences.
Non-pharmacological management options for MAFLD: a practical guide
Authors: Stefano José Tadeu , Duarte Sebastião Mauro Bezerra , Ribeiro Leite Altikes Renato Gama , Oliveira Claudia P.
Published: March 2023

Lifestyle changes should be the main basis for any treatment for metabolic dysfunction–associated fatty liver disease (MAFLD), aiming to increase energy expenditure, reduce energy intake and improve the quality of nutrients consumed. As it is a multifactorial disease, approaches such as physical exercise, a better dietary pattern, and possible pharmacological intervention are shown to be more efficient when used simultaneously to the detriment of their applications. The main treatment for MAFLD is a lifestyle change consisting of diet, activity, exercise, and weight loss. The variables for training prescription such as type of physical exercise (aerobic or strength training), the weekly frequency, and the intensity most indicated for the treatment of MAFLD remain uncertain, that is, the recommendations must be adapted to the clinical conditions comorbidities, and preferences of each subject in a way individual. This review addresses recent management options for MAFLD including diet, nutrients, gut microbiota, and physical exercise.
Team Science: Advancing Women and Black, Indigenous, and other People of Color on the Pathway of Conducting Clinical Research
Authors: Wiley Zanthia , Hanna Jasmah , Kobaidze Ketino , Franks Nicole
Published: March 2023

Introduction:

Innovative discovery begins with diverse perspectives; research teams should harness this model. Black, Indigenous, and other People of Color (BIPOC) and women are underrepresented as researchers. Team science leverages collaborative and cross-disciplinary approaches to diversify the research workforce, and introduces academic (and non-academic) faculty with limited research exposure/experience to clinical research.

Methods:

In 2020, two Black women academic physicians implemented an academic collaborative – COVID-19 Characteristics, Readmissions, Outcomes, and Social Determinants of Health (CROSS) – to investigate COVID-19 health inequities, with intentional recruitment of BIPOC and women. The 37 CROSS team members were of diverse races, ethnicities, sex, specialties, and disciplines, and represented eight hospitals. Team members were electronically surveyed to determine their interest, desired activities, and level of participation in research activities; concurrently, self-identified demographics (including race, ethnicity, sex, and language(s) spoken) were obtained.

Results:

All team members completed the survey: 78.4% ( n = 29) were BIPOC and 78.4% ( n = 29) were women. Team members spoke 18 languages (including English). Academic medical ranks included Assistant Professor (32.4%; n = 12), Associate Professor (16.2%; n = 6), and Full Professor (2.7%; n = 1). Each member identified desired activities (data collection, data analytics, manuscript development, abstract development/poster presentation, serving as a consultant) and the percentage of time they intended to allocate to each. Between June 2020 and February 2023, the team produced five original peer-reviewed manuscripts (including this article); five members served as first or senior authors. Twenty-one abstracts were presented at local conferences, and 10 at national and regional conferences. Five members achieved academic promotion, and team members were awarded three intramural grants resulting directly from team collaborations.

Conclusion:

Intentional recruitment and assessment of team members’ desired levels of participation in an integrated clinical research team is an effective strategy to engage BIPOC and women. The CROSS Collaborative is a model for diversity and inclusion in team science and clinical research.
Successful treatment of concomitant alopecia universalis and Crohn’s disease with upadacitinib: A case report
Authors: Johnston Leah A , Lu Cathy , Poelman Susan M
Published: March 2023

Alopecia areata is a non-scarring, autoimmune hair loss disorder that is associated with inflammatory bowel disease. Alopecia areata and inflammatory bowel disease may have a common pathogenic mechanism that involves the Janus kinase/STAT pathway. In addition, there are previous case reports of patients who developed alopecia areata while on biologic therapies for inflammatory bowel disease. JAK1 inhibitors are currently undergoing investigation as potential therapies for Crohn’s disease. Upadacitinib, an oral JAK1 inhibitor, has demonstrated efficacy in treating Crohn’s disease during phase III clinical trials. In this case report, we present a 23-year-old man with Crohn’s disease who previously developed alopecia areata while on adalimumab. He had near-complete resolution of his alopecia universalis after 7 months of treatment with upadacitinib while on concurrent ustekinumab for Crohn’s disease, which he had been taking for 16 months prior to starting upadacitinib. Upadacitinib may be a beneficial therapy for treating concomitant alopecia areata and Crohn’s disease.
Smart corruption: Satirical strategies for gaming accountability
Authors: Ghosh Ritwick , Faxon Hilary Oliva
Published: March 2023

Although new forms of data can be used to hold power to account, they also grant the powerful new resources to game accountability. We dub the latter behavior “smart corruption.” The concept highlights the possibility of appropriating algorithms, infrastructures, and data publics to accumulate benefits and obscure responsibility while leaning into the positive associations of transparency. Unlike conventional forms of corruption, smart corruption is disguised as progressive, and is thus difficult to spot or analyze through existing legal or ethical frameworks. To illustrate, we outline a satirical strategy for gaming accountability. Identifying the particular mechanisms and outcomes of transgressive activities carried out under the veneer of data-driven transparency, as well as the key actors and organizations most active in gaming accountability, is an important research and political project.
HIV and Addiction Services for People Who Inject Drugs: Healthcare Provider Perceptions on Integrated Care in the U.S. South
Authors: Bradford Davis , Parman Mariel , Levy Sera , Turner Wesli H. , Li Li , Leisch Leah , Eaton Ellen , Crockett Kaylee B.
Published: March 2023

This qualitative study evaluates physician training and experience with treatment and prevention services for people who inject drugs (PWID) including medications for opioid use disorder (MOUD) and HIV pre-exposure prophylaxis (PrEP). The Behavioral Model of Healthcare Utilization for Vulnerable Populations was applied as a framework for data analysis and interpretation. Two focus groups were conducted, one with early career physicians (n = 6) and one with mid- to late career physicians (n = 3). Focus group transcripts were coded and analyzed using thematic analysis to identify factors affecting implementation of treatment and prevention services for PWID. Respondents identified that increasing the availability of providers prescribing MOUD was a critical enabling factor for PWID seeking and receiving care. Integrated, interdisciplinary services were identified as an additional resource although these remain fragmented in the current healthcare system. Barriers to care included provider awareness, stigma associated with substance use, and access limitations. Providers identified the interwoven risk factors associated with injection drug use that must be addressed, including the risk of HIV acquisition, notably more at the forefront in the minds of early career physicians. Additional research is needed addressing the medical education curriculum, health system, and healthcare policy to address the addiction and HIV crises in the U.S. South.
Bringing Covid to College: Incoming First-Year College Students’ Making Meaning of the Pandemic
Authors: Velez Gabriel , Hoekstra Erin , Nemanich Samuel , Jessup-Anger Jody , Herteen Max
Published: March 2023

As time passes from the start of the COVID-19 pandemic in 2020, new cohorts of emerging adults transition to college, carrying with them experiences and effects of the pandemic on their lives and development. This study uses semi-structured interviews and reflexive thematic analysis to investigate how a cohort of 36 young people made narrative meaning of the pandemic in relation to their identities. Data were collected at the beginning of their first year at college and focused on their experiences of the pandemic, its impact on their lives, and the lessons they took away from it. Findings demonstrate that even amid deep and varied challenges, young people coped in nuanced ways and some built narratives of personal growth, development, new social identities, and maturing values. The study contributes to greater depth in understanding the impacts of the pandemic on young people as they develop into emerging adults.
The Influence of Multilevel Spinal Deformity Surgery on the EuroQol 5 Dimensions’ (EQ-5D) Questionnaire and Residential Status in the Elderly: A Prospective, Observational, Multicenter Study
Authors: Jentzsch Thorsten , Lewis Stephen J. , Oitment Colby , Rienmüller Anna , Martin Allan R. , Nielsen Christopher J. , Shear-Yashuv Hananel , de Kleuver Marinus , Qiu Yong , Matsuyama Yukihiro , Lenke Lawrence G. , Alanay Ahmet , Pellisé-Urquiza Ferran , Cheung Kenneth M. C. , Spruit Maarten , Polly David W. , Sembrano Jonathan N. , Shaffrey Christopher I. , Smith Justin S. , Kelly Michael P. , Dahl Benny , Berven Sigurd H. ,   AO Spine Knowledge Forum Deformity
Published: March 2023

Study Design

Multicenter, international prospective study.

Objective

This study investigated the clinical outcome up to 2 years after multi-level spinal deformity surgery in the elderly by reporting the minimal clinically important difference (MCID) of EuroQol 5-dimensions (EQ-5D), EQ-VAS, and residential status.

Methods

As an ancillary study of 219 patients ≥60 years with spinal deformity undergoing primary instrumented fusion surgery of ≥5 levels, this study focuses on EQ-5D (3-L) as the primary outcome and EQ-VAS and residential status as secondary outcomes. Data on EQ-5D were compared between pre-operatively and postoperatively at 10 weeks, 12 months, and 24 months. An anchor-based approach was used to calculate the MCID.

Results

The EQ-5D index and EQ-VAS, respectively, improved significantly at each time point compared to pre-operatively (from .53 (SD .21) and 55.6 (SD 23.0) pre-operatively to .64 (SD .18) and 65.8 (SD 18.7) at 10 weeks, .74 (SD .18) and 72.7 (SD 18.1) at 12 months, and .73 (SD .20) and 70.4 (SD 20.4) at 24 months). 217 (99.1%) patients lived at home pre-operatively, while 186 (88.6%), 184 (98.4%), and 172 (100%) did so at 10 weeks, 12 months, and 24 months, respectively. Our calculated MCID for the EQ-5D index at 1 year was .22 (95% CI .15-.29).

Conclusions

The EQ-5D index significantly increased at each time point over 24 months after ≥5 level spinal deformity surgery in elderly patients. The MCID of the EQ-5D-3 L was .22. Patients living at home pre-operatively can expect to be able to live at home 2 years postoperatively.
Black Protesters in a White Social Movement: Looking to the Anti–Iraq War Movement to Develop a Theory of Racialized Activism
Authors: Rojas Fabio , Heaney Michael T. , Adem Muna
Published: March 2023

On the basis of ethnographic and historical accounts, many movement scholars hold that differences in political expectations and interaction styles inhibit cross-racial collaboration in social movements. Inspired by this research, the authors ask three questions about minority participation in social movements and address them using a survey of more than 6,000 participants in the anti–Iraq War movement. First, the authors ask about relational inequality. Did Black protesters have fewer ties with the antiwar movement than Whites? Second, the authors ask about siloing. Were Black protesters disproportionately concentrated in specific movement organizations? Third, the authors ask if patterns of inequality were similar for Latino and Asian activists? The authors find evidence of relational inequality for Black activists but not Latino or Asian activists. They find evidence of siloing for all three ethnic groups. These empirical results are used to articulate an account of racialized activism with special attention to organizational processes.