bluuebunny/crossref_metadata_2025 huggingface dataset:
The Body Mass Index (BMI) of Human Age and Gender Structure as the Main Cause of Cardiovascular and Nephrotic Diseases
Authors: Beadini Sheqibe , Beadini Nexhbedin , Dalipi Besa , Iseni Gazmend , Aliu Hesat , Iseni Arburim
Published: June 2013

Background: Factors affecting the growth of the organism may be either endogenous, such as genetic factors like genetic heritage, or exogenous such as food, social and health status, physical activity, etc. A factor of great importance for human physical growth is BMI, a parameter defined as the ratio of human body weight and height. Aims:The purpose of this article is to determine the BMI in Macedonias population by analyzing age and gender, and finding the correlation of endogeneous and exogeneous factors and the BMI factor. All measurements were performed at the health facility. Surveys were also conducted for gathering information about gender, age, weight, height, eating habits, socioeconomic status, and education. Results: This clinical research studied 257 patients, 143 males and 114 females. Among other factors involved in this research are blood glucose, fat parameters and potential risk factors for cardiovascular and nephrotic diseases. Conclusions: After the discovery and identification of renal disease, the impact of BMI can be distinguished from pathological processes, such as irregular eating, various inflammations, and changes in the metabolism of vitamin D, etc. Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 256-262DOI: http://dx.doi.org/10.3329/bjms.v12i3.12618
A Case of Thyrotoxic Periodic Paralysis
Authors: Sarin Zacharia George , PK Rajakumari
Published: June 2013

Hypokalemic periodic paralysis is an uncommon manifestation of thyrotoxicosis and the condition is most commonly reported in young Asian men. Patient often presents with acute onset symmetrical flaccid muscle paralysis and proximal limb muscles may be more severely involved compared to distal muscles. Thyroid swelling as well as features of thyrotoxicosis may not be overt. A very high index of suspicion is often required for the diagnosis of thyrotoxic periodic paralysis. Treatment of throtoxicosis prevents further episodes of paralysis. We report a case of thyrotoxic periodic paralysis in a young male.Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 320-321 DOI: http://dx.doi.org/10.3329/bjms.v12i3.12719
Subacute Sclerosing Panencephalitis
Authors: Singal Kiran Kumar , Mittal Ajay , Talwar Neha , Singh Harjot , Khan Rao Farman , Lamba Harjoy
Published: June 2013

Subacute sclerosing panencephalitis (SSPE) is a rare,invariably fatal degenerative disease of central nervous system developing after measles infection.Neurological symptoms are initial presenting symtoms but rere reports of pure psychiatric symtoms preceding neurological symtoms have been reported..We here report a case of  18 years old male patient suffering from Subacute sclerosing panencephalitis (SSPE) who initially had behavioural changes and then subseqently devloped neurological symptoms.Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 344-345 DOI: http://dx.doi.org/10.3329/bjms.v12i3.12745
Cutaneous Leishmaniasis in El-Madinna Manowra region, Saudi Arabia in 2012.
Authors: Abdalla Nazar M , Abdelgani Abdelgani M , Osman Amani A , Sarhan Mohamed A
Published: June 2013

Objective: Leishmaniasis is a parasitic disease causing major public health problem in form of visceral and cutaneous types. The cutanoue leishmaniasis is caused by L. tropica, in low-land areas without reservoir; Arthroponatic leishmaniasis (ACL),  Zoonotic Cutaneous Leishmaniasis ( ZCL), in high-land. This case report involved; 25 years old Egyptian active young single male adult, stayed in Utama (75 Km far from El-Madina Manowra on the road to Makkah). He presented with three skin lesions on his arms occurred within the last 1-3 months. on examination revealed; volcano- like indurated ulcers which clinically suspected as leishmania lesions .Materials and Methods: Laboratory investigations were involved; skin smear using Giemsa stain, Leishmanin test (LST),  polymerase chain reaction (PCR), sequencing and phylogenitic analysis BLAST (NCBI).Results: Microscopy  positive LDB (leishmanin donovani bodies), Leishmanin test (LST) was negative. PCR  positive L. major . Sequence alignment were 100% with nine Iranian isolates and one Tunisian isolate. After one month of treatment with Pentostam (Sodium stibogluconate) local injections at the site of lesions the lesion progressed from ulcer to scar.Conclusion: L. major is a major species causing cutaneous leishmaniasis in Al-Medina Manowra region in Saudi Arabia. The usage of the polymerase chain reaction (PCR) is a useful diagnostic tool and help to identify the causative species.Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 325-330 DOI: http://dx.doi.org/10.3329/bjms.v12i3.13189
Subungual Malignant Melanoma: Difficulty in Early Diagnosis
Authors: Naveed Shah , Singh Gurpreet , Quari Hasina
Published: June 2013

A rare case of subungual malignant melanoma in a 43-year-old male, with black dystrophic right thumb nail plate with positive Hutchison sign is presented. Early detection in malignant melanoma is vital for improved treatment outcomes and prognosis. Subungual melanoma presents in a more disguised manner than cutaneous lesions and therefore requires increased vigilance and awareness [1]. Patient underwent disarticulation just distal to the proximal interphalangeal joint. Histopathology confirmed malignant melanoma, and resection free of tumour cells. Our case highlights how any pigmented lesions within the nail bed matrix should raise suspicion and the need for early referral and biopsy.Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 322-324 DOI: http://dx.doi.org/10.3329/bjms.v12i3.13200
Assessment of Nutritional Status among Adolescent Garo in Sherpur District, Bangladesh
Authors: Tamanna Sonia , Rana Md. Masud , Ferdoushi Aysha , Ahmad Shah Adil Ishtiyaq , Rahman Mustafizur , Rahman Atiqur
Published: June 2013

Background: Garo is one of the largest indigenous communities of Bangladesh. Adolescence is a golden period of time for nutritional promotion. Adolescent nutrition did not receive adequate attention in Bangladesh. Tribal people like the Garo are even more unaware about the importance of adolescent nutrition. Objectives: To find out physical growth as well as nutritional status among adolescent Garo children in Sherpur district on the basis of anthropometric indices. Methods and materials: This cross sectional descriptive study was conducted among 384 adolescent Garo children (boys and girls) aged 10- 18 years. A structured pre-tested questionnaire and a checklist were used to collect data through interview. Anthropometric survey of randomly selected adolescent was carried out and compared against the NCHS/WHO reference indicators such as BMI-for-age, Height-for-age and Weight-for-age. Standard methods were applied to measure the height and weight of the adolescent and BMI was calculated. Associations of nutritional status with socio-economic status, maternal working status, family type and family size were determined. Results: In most of the age groups it is notable that the mean height and weight of both boys and girls were lower than the WHO/NCHS standards. The prevalence of thinness, stunting and underweighting was 49.74%, 15.1% and 7.29% respectively. Conclusions: Significant association between malnutrition and socio-economic parameters was observed. So socio-economic status, maternal working status, family type and family size are important determinants of nutritional status of adolescent. Therefore, comprehensive programmes are required to be undertaken for the overall nutritional development of the Garo population with special focus on the adolescents. Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 269-275 DOI: http://dx.doi.org/10.3329/bjms.v12i3.15423
Cardio-protective properties of Momordica charantia in Albino Rats
Authors: Sheriff Ojulari Lekan , Yusuf FA
Published: June 2013

Momordica charantia, commonly known as bitter gourd, is used as a vegetable by the Asian community in Africa. It is frequently used as an anti-diabetic herb for the management of disease in the Ayurvedic system of Medicine. This present study was aimed at evaluating possible cardio-protective properties of M. charantia by determining its effect on blood cholesterol levels in albino rats. The study involved 25 rats and they were divided into 5 groups each comprising of 5 rats. The aqueous extract of M. Charantia was administered orally with syringes and cannula to 4 groups at different doses (80mg/kg, 100mg/kg, 120mg/kg and 140mg/kg body weights per day, respectively) and the last group served as the control and were given drug vehicle (normal saline) only. After two weeks of administration, the 25 rats were sacrificed and blood samples were collected and assayed for total blood cholesterol, triglyceride, highdensity lipoprotein and low-density lipoprotein levels. Results indicated that M. charantia plant extract increased significantly (P<0.05) the low density lipoprotein levels in the experimental group B (100mg/kg), and significantly reduced low density lipoprotein levels (P<0.05) in the experimental group A (80mg/kg), when compared to the control group. This study showed that M. charantia plant extract has cardio-protective properties by its dose-dependent effects on blood cholesterol. Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 291-297 DOI: http://dx.doi.org/10.3329/bjms.v12i3.15428
Patient satisfaction in national leprosy eradication programme
Authors: Mohite RV , Mohite VR , Durgawale PM
Published: June 2013

Background: Leprosy has been a literal scourge through the history of humanity and to eradicate the disease from high endemic countries need leprosy services to be sustained and they remain of good quality. Objective: The present study aimed for getting a reasonable impression of the clients views on a range of quality aspects of leprosy services rendered by district leprosy control unit under national leprosy eradication programme(NLEP). Methodology: Cross- sectional study was conducted in Satara district of western Maharashtra, India among registered leprosy patients under district leprosy control unit during April -July2008. A sample of 25 % of registered leprosy cases were selected by random sampling method from primary health centers and urban leprosy control units to assess the patients satisfaction under the functioning of NLEP. After verbal consent, participants were interviewed at home site using pre-tested structured proforma include socio -demographic and patient satisfaction variables. Data collected was compiled and analyzed by using statistical software. Results: Patients overall level of satisfaction was very good i.e. 88.89% with max, 46.03% cases were from age group 35 to 52 years. Max, 47.61% cases were illiterate with high case detection rate, 52.38% was seen males. The proportion of multi-bacillary (MB) and pauci-bacillary (PB) cases was 65.07 % & 34.92 % respectively. Most of the patients were satisfied with anti-leprosy drugs, health education and no physical deformity due to disease underline. 98.41 % patients were satisfied about follow- up and motivation services. Satisfaction about diagnosis of disease by doctors and starting of treatment was 96.82 % and 95.23 % respectively, however satisfaction with rehabilitative services was 14.28%. Significant statistical association was existed between age of leprosy affected cases and their level of satisfaction under NLEP services (?2=15.92,p <0.05*). Conclusion: Elimination of leprosy and very good patient satisfaction towards leprosy services in Satara district indicates successfulness of NLEP. Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Page 305-309 DOI: http://dx.doi.org/10.3329/bjms.v12i3.15430
Effects of fresh and digested cowdung and poultry litter on the growth and yield of cabbage (Brassica oleracea)
Authors: Shahariar MS , Moniruzzaman M , Saha B , Chakraborty G , Islam M , Tahsin S
Published: June 2013

A field experiment was conducted during Rabi season in the experimental field of BCSIR to see the effects of fresh and digested cowdung (CD) and poultry litter (PL) bio-slurry on the growth and yield of cabbage (Brassica oleracea). The experiment was laid in a Randomized Complete Block Design (CRBD) with six different treatments including control. Cabbage variety Atlas-70 was transplanted at the age of 35 days and was harvested at 120 days. Plant height, circumference, marketable weights and whole plant weight were examined to perceive the effects on the growth and yield of cabbages. The experiment revealed that both digested PL and CD bio-slurry had a significant effect (P < 0.01) on the growth and yield components of cabbage. Increased plant growth and yield were in the order of digested PL bio-slurry > digested CD bio-slurry > fresh PL > fresh CD in combination with recommended dose of fertilizers (RDF). Among the treatments, the highest head yield of cabbage (97.6 t ha-1) was obtained from RDF + 5 t ha-1 digested PL bio-slurry which was 366 % higher than the control. DOI: http://dx.doi.org/10.3329/bjsir.v48i1.15382 Bangladesh J. Sci. Ind. Res. 48(1), 1-6, 2013
Damage potential and control measures of Necrobia rufipes (De Geer) (Coleoptera: Cleridae) on dry fish with plant materials
Authors: Ahmed H , Ahmed KN , Khanom NP , Noor P
Published: June 2013

As a source of high protein content, fish is one of the major categories of foods consumed by human beings. In Bangladesh, fish provides the main and the cheapest source of animal protein in the diet of all walks of people. The process of drying and salting have been practised for fish preservation through centuries. Feeding by the larvae and adults of Necrobia rufipes (De Geer) causes quantitative loss of dried or cured fish and also leads to fragmentation and to quality losses and contamination by insects' bodies and cast skins. In our present study, about 20% damage was caused by N. rufipes in a storage period of six months (April to September). For preservation of dry fishes, five plant based materials namely Neem, Nishinda, Eucalyptus, Turmeric powder, Mehagoni and ash were evaluated. Each of the plant leaf powder at a concentration of 5 gm was uniformly mixed with 50 gm Punti dry fish and placed in a Petri dish (10 cm diam.). Five newly emerged (0-24 hrs old) larvae and adults of N. rufipes were introduced into each Petri dish. Neem leaf powder exerted the best result followed by turmeric powder, Nishinda, ash, Eucalyptus and Mehagoni leaf powders for preventing the larval infestations. Turmeric powder exerted the best result followed by Neem, Euclyptus, Mehagoni, Nishinda leaf powder and mehagoni oil- cake for ceasing infestation of dry fishes. DOI: http://dx.doi.org/10.3329/bjsir.v48i1.15409 Bangladesh J. Sci. Ind. Res. 48(1), 19-24, 2013
Techno-economic assessment of biogas production from press mud in Bangladesh
Authors: Rouf MA , Islam MS , Bajpai PK , Jotshic CK
Published: June 2013

To assess the potential of biogas generation, as a new and renewable source of energy, physico-chemical parameters of press mud have been determined. It has considerable amount of volatile matter (75-80%) and C/N ratio (13-15) is slightly lower than the normal requirement for biomethanation. The total gas yield was 0.18 L/g and it contained about 65% methane. Biogas generation was studied in a 150 cft plant in the field at solid concentrations of 6 to 8%. Acclimatization of the reactor has been done by initial start-up by cow dung and gradual mixing with press mud in order to generate biogas from press mud alone. The profitability of the considered plant has been assessed using the discounting and dynamic Net Present Value methods. The biogas and biofertilizer production from press mud was found to be economically feasible. DOI: http://dx.doi.org/10.3329/bjsir.v48i1.15414 Bangladesh J. Sci. Ind. Res. 48(1), 51-58, 2013
Self-Emulsifying Drug Delivery Systems: A Review
Authors: Reza Jamilur
Published: June 2013

Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble or lipophilic drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro- or nanoemulsions containing the solubilized drug. Owing to its miniscule globule size, the micro/nanoemulsified drug can easily be absorbed through lymphatic pathways, bypassing the hepatic first-pass effect. But it has drawbacks as formulation development, quality control, stability etc. These liquid SEDDS can be converted into solid dosage form without affecting drug release property. After administering the drug gets released and self emulsify in the GI tract. Generally solid SEDDS are formed with mono, di or triglycrides of fatty acid, non ionic surfactants and solidifying agents with diluents such as microcrystalline cellulose, lactose etc. DOI: http://dx.doi.org/10.3329/ijpls.v2i2.15453 International Journal of Pharmaceutical and Life Sciences Vol.2(2) 2013: 80-84
Drug Delivery to The Brain Using Polymeric Nanoparticles: A Review
Authors: Neha Bhatt , Ganesh Bhatt , Preeti Kothiyal
Published: June 2013

Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50300 nm generally). The use of minute particles as drug carriers for targeted treatment has been studied over a long period of time. A selective accumulation of active substances in target tissues has been demonstrated for certain so-called nanocarrier systems that are administered bound to pharmaceutical drugs. Great expectations are placed on nanocarrier systems that can overcome natural barriers such as the blood-brain barrier (BBB) and transport the medication directly to the desired tissue and thus heal neurological diseases that were formerly incurable. Polymeric Nanoparticle have been shown to be promising carriers for CNS drug delivery due to their potential both in encapsulating drugs, hence protecting them from excretion and metabolism, and in delivering active agents across the blood  brain barrier without inflicting any damage to the barrier. Different polymers have been used and different strategies like surface modification have been done to increase the retention time of nanoparticles. DOI: http://dx.doi.org/10.3329/ijpls.v2i3.15457 International Journal of Pharmaceutical and Life Sciences Vol.2(3) 2013: 107-132
Biochemical analysis of Five Dried Fish species of Bangladesh
Authors: Flowra Fawzia Adib , Nahar Dil Gulrukh , Tumpa Anannya Sen , Islam M Tariqul
Published: June 2013

To assess the proximate composition, five dried fish samples of Mystus vittatus, Channa punctatus, Chanda nama, Corica soborna and Trichuirus haumela were selected. The moisture content ranged from 14.06% to 24.58%, protein varied between 44.08% to 65.65% (moisture basis) and 53.45% to 76.39% (dry matter basis), lipid content of the selected dried fishes ranged from 1.91% to 17.76% (moisture basis) and 2.31% to 21.54% (dry matter basis). Ash content varied from 9.63% to 22.73% (moisture basis) and 11.21% to 28.15% (dry matter basis). The experiment was replicated three times and conducted from February, 2009 to August, 2009. Samples were collected from Sayedpur Upazaila, Nilphamari District, the north-west region of Bangladesh.DOI: http://dx.doi.org/10.3329/ujzru.v31i0.15373Univ. j. zool. Rajshahi Univ. Vol. 31, 2012 pp. 09-11
The efficacy of diatomaceous earth in mixed formulation with other dusts and an insecticide against the pulse beetles, Callosobruchus chinensis L. and Callosobruchus maculatus (F.)
Authors: Mahdi Shah Hussain Ahmad , Khalequzzaman M
Published: June 2013

Effectiveness of diatomaceous earth (DE) and other inert dusts (kaolin powder, paddy husk ash, coal ash, alluvial soil, china clay) and a dust formulation insecticide carbaryl have been tested on the pulse beetles Callosobruchus chinensis L. and C. maculatus (F.). The bioassay of the dusts was done on adult beetles by mixing them with normal food (lentil and black gram seeds). The LD50 of the combined doses of mixtures for C. chinensis have been calculated as 12703.57 and 859.36 ppm for DE+ kaolin powder; 2432.78 and 274.00 ppm for DE+ paddy hush ash; 3430.036 and 426.16 ppm for DE+ coal ash; 12563.47 and 652.29 ppm for DE+ alluvial soil; 2242.81 and 325.76 ppm for DE+ china clay; and 21.33 and 14.45 ppm for DE+ carbaryl after 24 and 48 h after treatment respectively. The LD50 of combined doses of different mixtures for C. maculatus have been calculated as 3640.65 and 503.74 ppm for DE+ kaolin powder; 54946.68 and 987.2394 ppm for DE + paddy hush ash; 61029.04 and 3229.436 ppm for DE+ coal ash; 61029 and 4265.599 ppm for DE+ alluvial soil; 4648.786 and 642.278 ppm for DE+ china clay; and 24.12017 and 15.47023 ppm for DE+ carbaryl after 24 and 48 h after treatment respectively. The co-toxicity coefficient has been calculated and all ratios showed synergistic action. The highest co-toxicity coefficient was recorded as 88885.15 and 92107.22 in DE+ carbaryl at 24 and 48 h after treatment for C. chinensis and 78615.55 and 86004.88 in DE+ carbaryl at 24 and 48 h after treatment for C. maculatus. DOI: http://dx.doi.org/10.3329/ujzru.v31i0.15436Univ. j. zool. Rajshahi Univ. Vol. 31, 2012 pp. 73-78
Influence of Levamisole and Other Angiogenesis Inhibitors on Angiogenesis and Endothelial Cell Morphology in Vitro
Authors: Friis Tina , Engel Anne-Marie , Bendiksen Christine , Larsen Line , Houen Gunnar
Published: June 2013

Angiogenesis, the formation of new blood vessels from existing vessels is required for many physiological processes and for growth of solid tumors. Initiated by hypoxia, angiogenesis involves binding of angiogenic factors to endothelial cell (EC) receptors and activation of cellular signaling, differentiation, migration, proliferation, interconnection and canalization of ECs, remodeling of the extracellular matrix and stabilization of newly formed vessels. Experimentally, these processes can be studied by several in vitro and in vivo assays focusing on different steps in the process. In vitro, ECs form networks of capillary-like tubes when propagated for three days in coculture with fibroblasts. The tube formation is dependent on vascular endothelial growth factor (VEGF) and omission of VEGF from the culture medium results in the formation of clusters of undifferentiated ECs. Addition of angiogenesis inhibitors to the coculture system disrupts endothelial network formation and influences EC morphology in two distinct ways. Treatment with antibodies to VEGF, soluble VEGF receptor, the VEGF receptor tyrosine kinase inhibitor SU5614, protein tyrosine phosphatase inhibitor (PTPI) IV or levamisole results in the formation of EC clusters of variable size. This cluster morphology is a result of inhibited EC differentiation and levamisole can be inferred to influence and block VEGF signaling. Treatment with platelet factor 4, thrombospondin, rapamycin, suramin, TNP-470, salubrinal, PTPI I, PTPI II, clodronate, NSC87877 or non-steriodal anti-inflammatory drugs (NSAIDs) results in the formation of short cords of ECs, which suggests that these inhibitors have an influence on later steps in the angiogenic process, such as EC proliferation and migration. A humanized antibody to VEGF is one of a few angiogenesis inhibitors used clinically for treatment of cancer. Levamisole is approved for clinical treatment of cancer and is interesting with respect to anti-angiogenic activity in vivo since it inhibits ECs in vitro with a morphology resembling that obtained with antibodies to VEGF.
Bending of Layer-by-Layer Films Driven by an External Magnetic Field
Authors: Miyazaki Celina , Riul Antonio , Dos Santos David , Ferreira Mariselma , Constantino Carlos , Pereira-da-Silva Marcelo , Paupitz Ricardo , Galvão Douglas , Jr. Osvaldo
Published: June 2013

We report on optimized architectures containing layer-by-layer (LbL) films of natural rubber latex (NRL), carboxymethyl-chitosan (CMC) and magnetite (Fe3O4) nanoparticles (MNPs) deposited on flexible substrates, which could be easily bent by an external magnetic field. The mechanical response depended on the number of deposited layers and was explained semi-quantitatively with a fully atomistic model, where the LbL film was represented as superposing layers of hexagonal graphene-like atomic arrangements deposited on a stiffer substrate. The bending with no direct current or voltage being applied to a supramolecular structure containing biocompatible and antimicrobial materials represents a proof-of-principle experiment that is promising for tissue engineering applications in biomedicine.
Achillea millefolium L. Essential Oil Inhibits LPS-Induced Oxidative Stress and Nitric Oxide Production in RAW 264.7 Macrophages
Authors: Chou Su-Tze , Peng Hsin-Yi , Hsu Jaw-Cherng , Lin Chih-Chien , Shih Ying
Published: June 2013

Achillea millefolium L. is a member of the Asteraceae family and has been used in folk medicine in many countries. In this study, 19 compounds in A. millefolium essential oil (AM-EO) have been identified; the major components are artemisia ketone (14.92%), camphor (11.64%), linalyl acetate (11.51%) and 1,8-cineole (10.15%). AM-EO can suppress the inflammatory responses of lipopolysaccharides (LPS)-stimulated RAW 264.7 macrophages, including decreased levels of cellular nitric oxide (NO) and superoxide anion production, lipid peroxidation and glutathione (GSH) concentration. This antioxidant activity is not a result of increased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, but rather occurs as a result of the down-regulation of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) expression, thus reducing the inflammatory response. Therefore, AM-EO can be utilized in many applications, including the treatment of inflammatory diseases in the future.
TDAE Strategy for the Synthesis of 2,3-Diaryl N-Tosylaziridines
Authors: Khoumeri Omar , Spitz Cédric , Terme Thierry , Vanelle Patrice
Published: June 2013

We report herein an original and rapid synthesis of 2,3-diaryl N-tosylaziridines by TDAE strategy starting from ortho- or para-nitro(dichloromethyl)benzene derivatives and N-tosylimines. A mixture of cis/trans isomers was isolated from 1-(dichloromethyl)-4-nitrobenzene, whereas only trans-aziridines were obtained from ortho-nitro derivatives.
Performance Analysis of Mobile Laser Scanning Systems in Target Representation
Authors: Lin Yi , Hyyppä Juha , Kaartinen Harri , Kukko Antero
Published: June 2013

The technology of mobile laser scanning (MLS) has developed rapidly in recent years. This speedy development is evidenced by the emergence of a variety of MLS systems in commercial market and academic institutions. However, the producers tend to supply the specifications of the individual sensors in a generic sense, and this is not enough for guiding the choice of a MLS system for a specific application case. So far, the research efforts comparing the efficacy ranges of the existing MLS systems have been little reported. To fill this gap, this study examined the performance of three typical MLS systems (Riegl VMX-250, Roamer and Sensei) in terms of target representation. Retrievals of window areas and lighting pole radiuses served as representative cases, as these parameters correspond to the spatial scales from meter to centimeter. The evaluations showed that the VMX-250 with highest sampling density did best, and thus, it was preferred in the scenario of this study. If both the cost and efficacy were regarded, Roamer was a choice of compromise. Therefore, an application-oriented scheme was suggested for selecting MLS systems to acquire the desired performance.
La maison de la première moitié du XIVe siècle dans les castra du nord de la Corse
Authors: Istria Daniel
Published: June 2013

Le recensement des habitats médiévaux désertés du département de Haute- Corse et l'étude archéologique de deux d'entre eux - Cortone et Mugliunaccia - constituent la base d'un travail sur la maison des bourgs fortifiés de la première moitié du XIVe siècle. L'étude des techniques de construction, des plans, de l'organisation et de l'aménagement des espaces intérieurs débouche sur une première typologie qui fait apparaître la relative homogénéité de cet habitat rural perché et ses similitudes évidentes avec les maisons, bien connues aujourd'hui, du nord de l'Italie.
L'architecture civile franque à Césarée, Acre et Jérusalem.
Authors: Boas Adrian
Published: June 2013

Les fouilles archéologiques et relevés menés depuis plusieurs décennies en Israël ont mis au jour les restes d'un grand nombre d'édifices civils de la période franque (1099-1291), en zone urbaine comme rurale. Dans cet article, j'ai choisi de présenter certaines maisons de trois villes du royaume de Jérusalem : celle de Césarée, jadis ville portuaire d'importance dont le rôle s'est amoindri au Moyen Age, ce qui se reflète dans ses maisons très simples ; la ville portuaire d'Acre, où se trouvent les vestiges de nombreux édifices civils de belle facture ; enfin Jérusalem, où vraisemblablement assez peu de maisons ont été construites par les Francs, qui occupèrent en 1099 une cité presque intacte et vidée de sa population.
Les chapiteaux des portes de l'enceinte de Césarée (1251-1252) : de la tradition romane à l'art gothique
Authors: Kenaan-Kedar Nurith
Published: June 2013

Die Kapitelle der Stadttore von Cäsarea (1251-1252) : von der romanischen Tradition zur gotischen Kunst, von Nurith Kenaan-Kedar

Traditionell hat man die mittelalterliche Bauskulptur des lateinischen Kônigreichs Jérusalem immer als einfaches Bindeglied der Einflüsse von Okzident und Orient gesehen. Es scheint jedoch, dass das lateinische Königreich des 12. und 13. Jahrhunderts selbst auch ein regelrechter schöpferischer Brennpunkt innerhalb der künstlerischen Entwicklung des Westens gewesen ist. So ist der romanische Stil des Königreichs Jerusalem wie in zahlreichen Schaffenszentren Frankreichs, Italiens oder Spaniens durch den Rückgriff auf Akanthusblattkapitelle oder bevölkerte Ranken gekennzeichnet, die von lokalen antiken oder von der Antike abgeleiteten Vorbildern inspiriert sind. In der gotischen Epoche, im 13. Jahrhundert, herrschte auch im lateinischen Königreich das neue Kapitellrepertoire auf der Basis naturalistisch inspirierten Blattdekors vor, das man auch im Westen antrifft. Solche Kapitelle finden sich unter anderem an den Befestigungen von Cäsarea - insbesondere an den Toren - die unter Ludwig dem Heiligen zwischen März 1251 und Mai 1252 errichtet wurden.
Eudes de Montreuil, maître des œuvres des fortifications de Jaffa, une légende franciscaine ?
Authors: Prouteau Nicolas
Published: June 2013

Pendant près d'une année (mai 1252 à juin 1253), Saint Louis ordonna et dirigea la refortification de l'enceinte urbaine de Jaffa. L'investissement personnel du roi dans la construction et la vaste campagne de fortifications menée le long du littoral levantin sont rapportés dans différentes sources, depuis les chroniques contemporaines des événements aux compilations de l'époque moderne. Le nom d'Eudes de Montreuil, maître-maçon du roi, est traditionnellement associé à la construction de l'enceinte fortifiée de Jaffa. Bien que cet argument ait été recopié du XVIII siècle jusqu'à Paul Deschamps, un examen méticuleux de la documentation médiévale et moderne remet en cause cette idée communément admise. La participation de « l'illustre architecte » à ce chantier oriental n'est en fait qu'une « légende » mise en scène par André Thévet. Une réécriture patriotique qui est pourtant devenue réalité historique.
Simvastatin Inhibits Proliferation and Induces Apoptosis in Human Lung Cancer Cells
Authors: Yu Xiaofeng , Pan Yinghua , Ma Housheng , Li Wenjun
Published: June 2013

Lung cancer is the one of the most frequent causes of malignant tumors. In recent years, it has been documented that statins have anticancer and cancer chemopreventive properties. However, the mechanism of simvastatin on lung cancer is still unclear. In this study, the human lung cancer cell line A549 cells were incubated with simvastatin. Simvastatin inhibited the survival of A549 cells in a dose-dependent manner, decreased Bcl-2 protein expression, and increased Bax protein expression time and dose dependently. In addition, simvastatin blocked cells in the G1phase of the cell cycle, downregulated cyclin D1 and CDKs protein expression, mediated the mitochondria-dependent caspase cascade by increasing caspase-3, -8, and -9 mRNA and protein expression, downregulated Xiap levels to induce cells apoptosis. Importantly, simvastatin suppressed decreased MMP-9 protein expression and suppressed NF-κB activation in A549 cells. Taken together, these results showed that the anticancer effect of simvastatin in lung cancer A549 cells via the inhibiting cell proliferation, influencing the cell cycle, downregulating cyclin D1 and CDKs expression, inducing apoptosis, and decreasing MMP-9 levels, possibly by inhibiting the activation of NF-κB. Statins contribute to lung cancer therapy and may be an ideal anticancer and cancer chemopreventive agent for lung cancer.
Oldhamianoside II, a New Triterpenoid Saponin, Prevents Tumor Growth via Inducing Cell Apoptosis and Inhibiting Angiogenesis
Authors: Wang Feng-Ling , Sun Jing-Yong , Wang Yan , Mu Yan-Ling , Liang Yu-Ji , Chong Zhao-Zhong , Qin San-Hai , Yao Qing-Qiang
Published: June 2013

Oldhamianoside II is a new triterpenoid saponin that was isolated from the roots of Gypsophila oldhamiana. The present study aims to investigate the potential inhibitory activity of oldhamianoside II on tumor growth using an S180 tumor implantation mouse model. Oldhamianoside
II at doses of 5.0 and 10.0 mg/kg was given with intraperitoneal injection for 10 days following subcutaneous inoculation of S180 tumor cells in anterior flank of mice. The tumor growth, the cell apoptosis, the microvessel density (MVD) in S180 tumors, the tumor cell viability, the tubular
formation in vitro, and migration of tumor cells were examined. The expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and cyclooxygenase-2 (COX-2) was determined to analyze the associated mechanisms. The results showed that oldhamianoside II potently
inhibited tumor cell viability in vitro. In addition, oldhamianoside II delayed tumor growth in anterior flank, induced S180 cell apoptosis, and reduced the MVD. Oldhamianoside II was also demonstrated to decrease the number of tubular structure and vessel formation in HUVEC cultures and chick
embryo chorioallantoic membrane (CAM) model, respectively. Further study indicated that oldhamianoside II reduced the expression of VEGF, bFGF, and COX-2 in tumor sections. Moreover, oldhamianoside II inhibited the activity of migration and penetration to Matrigel of SGC7901 tumor cells in
scratch wound and transwell chamber. In conclusion, our work defines oldhamianoside II, a new triterpenoid saponin, as a novel compound that can effectively inhibit S180 tumor growth, induce tumor cell apoptosis, prevent tumor angiogenesis, and inhibit cancer cell migration, suggesting that
oldhamianoside II is a potential drug candidate for the treatment of cancer and for the prevention of metastasis.
El European Reference Index for the Humanities (ERIH) como criterio de calidad de las revistas académicas: análisis de la lista revisada de educación
Authors: Aliaga Francisco M. , Almerich Gonzalo , Suárez-Rodríguez Jesús M.
Published: June 2013

El European Reference Index for the Humanities (ERIH) se ha propuesto (y reconocido oficialmente en nuestro país) como una alternativa europea al predominio de índices y bases de datos que presentan un conocido sesgo anglosajón. Se pretende con ello dar una mayor visibilidad a la investigación europea en Humanidades y en algunas Ciencias Sociales. Se espera cubrir mejor la diversidad cultural y lingüística del viejo continente. Analizamos algunas de las circunstancias que determinan los resultados obtenidos en la lista recientemente actualizada de ERIH (‘revisada’), haciendo especial hincapié en el ámbito educativo. Los resultados muestran la necesidad de mejorar los criterios de entrada en el índice (exhaustividad y calidad) si ERIH quiere alcanzar sus objetivos.
Comparación de campos de LILACS Descripción Bibliográfica e Indización (LILDBI) con entidades y atributos de los Requerimientos Funcionales para Registros Bibliográficos
Authors: Santana-Arroyo Sonia
Published: June 2013

En el presente trabajo se realiza una breve caracterización de la Metodología LILACS y los Requerimientos Funcionales para Registros Bibliográficos (FRBR). Se comparan los campos más utilizados por bibliotecarios, del programa LILDBI (LILACS Descripción Bibliográfica e Indización), componente de la Metodología LILACS, con las entidades y atributos del modelo FRBR. Se esbozan además, brevemente, los beneficios potenciales de la integración de este modelo a la base de datos LILACS, para proporcionar a los usuarios finales una mejor visualización y comprensión de las interfaces de búsqueda y recuperación de información bibliográfica.
La Universidad del siglo XXI: nueva docencia, nuevo bibliotecario
Authors: Extremeño Ana , Amante María João , Firmino da Costa António
Published: June 2013

La metodología en los procesos de enseñanza-aprendizaje en los Centros de Enseñanza Superior está experimentando unos cambios profundos que también los implica en la propia organización educativa. A ello hay que añadir que los avances tecnológicos e Internet han contribuido de forma decisiva a un aprendizaje más abierto e interactivo que obliga a los profesionales de la información a adoptar nuevos roles para hacer frente a los retos que se le presentan, así como a nuevos comportamientos para lograr los compromisos que se les demandan. Atendiendo a estas premisas y teniendo en cuenta sus implicaciones, el objetivo de este trabajo es definir el nuevo concepto de bibliotecario en los Centros de Enseñanza Superior.
Políticas de acceso abierto a la ciencia en las universidades españolas
Authors: Abadal Ernest , Ollé Castellà Candela , Abad-García Francisca , Melero Remedios
Published: June 2013

El objetivo del artículo es analizar el estado de la cuestión de las políticas en favor del acceso abierto (OA) a la ciencia en las universidades españolas. Para ello se han establecido cinco grandes mecanismos de intervención (la creación de infraestructuras y prestación de servicios, la comunicación y difusión, la incentivación económica, la coordinación institucional así como la reglamentación u obligación) que permiten llevar a cabo políticas a favor del acceso abierto y que hemos utilizado para el análisis y la valoración de la situación. La recogida de datos se ha basado en un cuestionario enviado a los vice-rectores de investigación y se ha complementado con la consulta de directorios de repositorios, revistas científicas españolas y políticas institucionales de acceso abierto. Los resultados muestran un panorama diversificado en relación a las actuaciones llevadas a cabo, pero han permitido clasificar las universidades en cinco grupos en función del número y de la calidad de acciones que han realizado. El primero, formado por siete universidades (9% del total) que disponen de una política completa en acceso abierto. El segundo incluye a doce universidades (16%) con una política destacada. El tercero, diecisiete centros (23%) con una política encaminada y el cuarto incluye otras diecisiete universidades (23%) que han implementado una o dos acciones. Finalmente, quedan las 21 universidades (28%) que no disponen de ninguna acción para favorecer el acceso abierto a la ciencia.
Ciertas ventajas de Scopus sobre Web of Science en un análisis bibliométrico sobre tabaquismo
Authors: Granda-Orive José Ignacio , Alonso-Arroyo Adolfo , García-Río Francisco , Solano-Reina Segismundo , Jiménez-Ruiz Carlos Andrés , Aleixandre-Benavent Rafael
Published: June 2013

El objetivo de este trabajo es comparar entre Web of Science (WoS) y Scopus los indicadores bibliométricos básicos del área de tabaquismo de autores españoles en el período 2000-2009. Métodos: La búsqueda se realizó en el SCI-Expanded y Scopus (“smok*” OR “tobac*”). Resultados: La media total anual del nº de documentos fue de 41 ± 12 para WoS vs 60 ± 16 en Scopus (p = 0,007). Aumento progresivo del índice de colaboración. La media anual del índice de colaboración fue de 9,41 ± 2,73 en WoS vs 7,12 ± 1,52 en Scopus (p = 0,029). Mayor número de citas con el paso del tiempo en ambas bases de datos pero son más recientes las citas en Scopus, el índice citas/artículo fue mayor en WoS (WoS 14,47 vs 11,50 Scopus). Conclusiones: Mayor número de revistas, trabajos, firmas y citas en Scopus comparado con WoS. El índice firmas/artículo e instituciones/artículo fue mayor en WoS. Incremento del índice de colaboración y mayor acúmulo de citas en los artículos más antiguos, pero más recientes en Scopus.
¿Existe relación entre el tamaño del grupo de investigación y su rendimiento científico? Estudio de caso de una universidad española
Authors: Cabezas-Clavijo Álvaro , Jiménez-Contreras Evaristo , Delgado López-Cózar Emilio
Published: June 2013

Se presenta un análisis del rendimiento de grupos de investigación desde una perspectiva bibliométrica. Tomando como caso de estudio los grupos de investigación de la Universidad de Murcia, salvo los del área de Humanidades (n=258), se indaga en la relación entre el tamaño del grupo de investigación, y su rendimiento científico, usando para ello medidas bibliométricas absolutas y relativas. Los resultados indican que los grupos con más miembros muestran valores absolutos de producción, visibilidad e impacto más elevados que el resto de grupos, como consecuencia de su mayor tamaño. En lo que respecta a los indicadores relativos, se concluye que existe relación estadísticamente significativa entre tamaño del grupo y porcentaje de publicación en revistas del primer cuartil, así como con el valor de citas normalizado. Estos resultados vienen dados por el área de Ciencias Sociales donde la productividad per cápita también se ve afectada positivamente por el mayor tamaño del grupo de investigación. En las restantes áreas, sin embargo, no hay evidencia estadística de que los indicadores relativos estén influidos por el tamaño del grupo de investigación. Finalmente, se discuten las implicaciones de estos resultados para la toma de decisiones en política científica.
Fuzzy Analytic Hierarchy Process and Its Application to E-Marketplace Selection
Authors: Ozkok Beyza Ahlatcioglu , Pappalardo Elisa
Published: June 2013

Making decisions is a part of daily life. The nature of decision-making includes multiple and usually conflicting criteria. Multi Criteria Decision-Making (MCDM) problems are handled under two main headings: Multi Attribute Decision Making (MADM) and Multi Objective Decision Making (MODM). Analytic Hierarchy Process (AHP) is a widely used multi-criteria decision making approach and has successfully been applied to many practical problems. Traditional AHP requires exact or crisp judgments (numbers). However, due to the complexity and uncertainty involved in real world decision problems, decision makers might be more reluctant to provide crisp judgments than fuzzy ones. Furthermore, even when people use the same words, individual judgments of events are invariably subjective, and the interpretations that they attach to the same words may differ. This is why fuzzy numbers and fuzzy sets have been introduced to characterize linguistic variables. Here, the authors overview the most known fuzzy AHP approaches and their application, and they present a case study to select an e-marketplace for a firm, which produces and sells electronic parts of computers in Turkey.
Sustainable Waste Management System and Reverse Logistic Network Design in Plastic Industry
Authors: Aydogan Emel Kizilkaya , Ates Nuray , Uzal Nigmet , Zaral Fulya , Papajorgji Petraq
Published: June 2013

The shortage of natural sources and the threat of the bad trend have forced the industries to find environmentally-friendly alternatives and ecological approaches in their production line. In some countries, regulations have been issued for industries about this subject. Due to these reasons and more of them, logistic firms have been forced to take into consideration decreasing material and energy consumption and minimizing waste production in planning their network designs. In practice, it might be necessary to simultaneously optimize more than one conflicting objective to obtain effective and realistic solutions. In this chapter, current logistics network design of a plastic industry in Turkey has been investigated and reverse logistics network design has been developed to minimize waste production and to achieve green production. This chapter presents a mathematical model which is a fuzzy goal programming model for imprecise goals for reverse logistic network design with multiple objectives in plastic sector. The considered objectives are to reduce cost in reverse logistics, to improve product quality, and to provide environmental benefits by minimizing waste production.
E-Ophthalmology in the Diagnosis and Follow-Up of Chronic Glaucoma
Authors: Andonegui Jose , Eguzkiza Aitor , Auzmendi Mikel , Serrano Luis , Zurutuza Ane , Pérez de Arcelus Mónica
Published: June 2013

e-Ophthalmology is the use of information and telecommunications technologies to provide or support a group of activities related to ophthalmic care. Chronic glaucoma is an ocular disease characterized by optic neuropathy that leads to progressive loss of the visual fields and often is associated with elevated intraocular pressure levels. Glaucoma is an important public health problem because it is one of the main causes of blindness worldwide and generates an important demand for ophthalmologic consultations. The aim of this chapter is to discuss the application e-Ophthalmology-based models in the diagnosis and follow-up of chronic glaucoma. The authors describe the current status of the use of e-Ophthalmology-based models in the screening and follow-up of chronic glaucoma, the main advantages of these models, the technologic requirements for their implementation, and future trends in this field.
The Information and Communication Strategies Focused on Young People and Adolescents within the Field of Public Health
Authors: Sabelli Martha , Rasner Jorge , Giffoni María Cristina Pérez , Pedrosian Eduardo Álvarez
Published: June 2013

Within the framework of the implementation of the Integrated National Healthcare System (SNIS) along with national policies of information and communication at the República Oriental del Uruguay, a research is being conducted, focusing on adolescents and young people in vulnerable contexts in the city of Montevideo, taking them as both real and potential users of healthcare information. It also centers in the mediators in the flow of communication and information, especially among healthcare staff. From a multi-interdisciplinary approach, this investigation aims at identifying the behaviors and needs of the target population in relation to the information and ICTs, the availability and access to personal technological resources, its context of use (the community, their everyday lives, the institutions), the process of interaction among the different social actors in the sector, as well as in the communication flow within the organizational culture of these services. On this basis, it will provide models to design electronic information resources according to the social needs, and which may contribute to the inclusion of all citizens in the so-called Information Society.