bluuebunny/crossref_metadata_2025 huggingface dataset:
Flying with Covid: The visual presence of the pandemic in airports
Authors: Bollettin Paride
Published: December 2021

Since the beginning of 2020, with the eclosion of the Covid-19 pandemic, airports have been included among the main hotspots for the diffusion of the disease. Several limitations affected the possibility for people to travel, with diverse approaches between the countries, and with differences among who was authorized to travel and who was not. This caused a contraction on the number of passengers transiting in the airports in all the countries. However the commercial international aviation has never stopped, and despite the reduction of passengers the airports managed to implement health security protocols for the Covid-19 diffusion control. Before the pandemic, other challenges already affected airports’ security protocols, such as the “terrorist threat”, making of these places “nervous systems” (as defined by Maguire and Pétercsak). After one year and half from the beginning of the pandemic, with the vaccination campaigns accelerating in various countries (with the clear differences due to governments’ political choices and countries’ access to vaccines) the air travels have returned to a condition similar to previous one. An increasing number of planes flying and an increasing number of passengers can be registered everywhere. Meanwhile, the sanitary attention to the Covid-19 diffusion contention continues to be a concern in the space organization of airports.This ethnographic photoessay aims at describing the visual presence of the Covid in the airports. The work focuses on four airports in three countries the author passed through in June 2021. They are the airports of Salvador da Bahia (Brazil), Lisbon (Portugal), Rome and Venice (Italy). Despite the differences between the countries in the approached adopted to contain the diffusion of the pandemic, airports are subjected to standardized international protocols. These are intended to (re)produce similar safety measures in the diverse airports. Meanwhile, airports are designed not to be identitarian, historical and relational, but yes to be experienced as “non places” (as Augé defined these places). However, each airport introduces several dimensions of its specific location, of its specific local health politics, of its specific passengers’ flow, and so on, making of them a peculiar place to observe the space design for Covid diffusion control. Despite the definition of the Covid as an “invisible enemy”, used in general media in diverse countries, the thesis is that the presence of the virus is highly visible to everyone passing in some airport, independently from the specific country. Meanwhile, the diverse airports introduce their own local and specific visual modalities to achieve passengers. Pictures included in this ethnographic photoessay focus on some of these modalities, such as the hand gel dispensers, instructions and prohibitions for preventing Covid dissemination, among other. Covid’s aesthetics in airports highlights how the pandemic affected people visual and sensorial experiences of these places and of their designs.
Formation of research competencies among students in the course of physics. Manipulative and dialogic strategies
Authors: Антифеева Е.Л.
Published: December 2021

В статье рассматриваются вопросы проектирования учебного процесса, с учетом наиболее оптимальных для достижения образовательных задач подходов, необходимости формирования профессиональных компетенций и профессиональной культуры при подготовке специалистов в области машиностроения, физико-технических наук и технологий, авиационной и ракетно-космической техники. Определяется возможность организации учебного процесса как некоторых этапов, на каждом из которых должна решаться определенная образовательная задача. Обосновывается необходимость пересмотра и внедрения новых форм взаимодействия участников образовательного процесса. Рассмотрены возможности курса физики и обоснована целесообразность использования манипулятивной стратегии для формирования исследовательских компетенций у обучающихся вузов. Материал представленный в статье является обобщением опыта преподавания физики в Военно-космической академии имени А.Ф. Можайского. Статья предназначена для преподавателей физики вузов.

The article deals with the issues of designing the educational process, taking into account the most optimal approaches for achieving educational objectives, the need for the formation of professional competencies and professional culture in the training of specialists in the field of mechanical engineering, physical and technical sciences and technologies, aviation and rocket and space technology. The possibility of organizing the educational process as some stages is determined, at each of which a certain educational task must be solved. The necessity of revision and introduction of new forms of interaction of participants in the educational process is substantiated. The possibilities of the physics course are considered and the expediency of using a manipulative strategy for the formation of research competencies among university students is substantiated. The material presented in the article is a generalization of the experience of teaching physics at the Military Space Academy named after A.F. Mozhaisky. The article is intended for university physics teachers.
Training of translators at the university: new challenges
Authors: Вершинина Т.С. , Кочева О.Л.
Published: December 2021

Актуальность статьи обусловлена несоответствием содержания вузовской подготовки переводчиков требованиям, предъявляемым современной профессиональной средой к выпускникам этого направления. Описаны результаты трехлетнего исследования, нацеленного на выявление набора переводческих компетенций, включающих, кроме лингвистических и метакогнитивных навыков, личностные характеристики и умения регулировать социокультурные противоречия. Показано, что в контексте межъязыкового общения переводчик выступает регулятором коммуникации, а, значит, должен демонстрировать эффективные приемы воздействия на индивидуальное или групповое сознание. Авторы убеждены, что развитие новых качеств может также положительно сказаться на уровне мотивации будущих переводчиков, что было подтверждено в ходе проведенного формирующего эксперимента. Статья предназначена для руководителей образовательных переводческих программ и специалистов в области перевода, планирующих разработку алгоритма применения нового профессионального стандарта «Специалист в области перевода».

The relevance of the article is due to the inconsistency of the content of the university training of translators with the today’s professional requirements placed on the graduates of this direction of studies. The article describes the results of a three-year study aimed at identifying a set of translation competencies, including, in addition to linguistic and metacognitive skills, personal characteristics and the ability to regulate socio-cultural contradictions. It is shown that in the context of interlingual communication, the translator acts as a regulator of communication, and, therefore, must demonstrate effective methods of influencing individual or group consciousness. The authors are convinced that the development of new qualities can also have a positive effect on the level of motivation of future translators, which was confirmed by the formative experiment. The article is intended for managers of educational translation programs and specialists in the field of translation who plan to develop an algorithm for applying the new professional standard "Specialist in the field of translation".
Past ecosystems drive the evolution of the early diverged Symphyta (Hymenoptera: Xyelidae) since the earliest Eocene
Authors: Jouault Corentin , Aase Arvid , Nel André
Published: December 2021

Abstract. Paleoxyela nearctica gen. et sp. nov., is described from the upper Eocene of
Florissant Formation in Colorado. We placed Paleoxyela gen. nov. in the subfamily
Macroxyelinae and the tribe Macroxyelini based on the numerous wing venation
characters visible on the specimen. Proxyelia pankowskii gen. et sp. nov. is described from the
lower Eocene Fossil Lake deposits of the Green River Formation in Wyoming.
We placed Proxyelia gen. nov. in the subfamily Macroxyelinae and the tribe Xyeleciini
based on the numerous wing venation characters visible on the specimen.
These new records of the family Xyelidae are of particular importance to
better understand the past diversity of the clade and propose hypotheses
about their diversification. Extant Xyelidae inhabit temperate Northern
Hemisphere forests, and most of their larvae feed on conifers, which may
explain why they are relatively poorly diversified compared to the other
symphytan families. We suggest that the global decline in conifers and the
reduced diversity of extant host trees partly explain the diversity of
extant Xyelidae. We correlate the biome repartition during the Eocene to
that of the extant xyelid.
Law, Justice, and Indigenous Intergenerational Trauma—A Genealogy
Authors: McCallum David
Published: December 2021

Aboriginal Australians experience trauma that is linked to continuing colonising practices in the present, and which are also reproduced throughout the more than 230 years of colonisation. Intergeneration trauma intersects with the over-representation of Aboriginal people in the welfare and justice systems. This paper examines evidence of the relations between trauma and colonialising practices imposed on Indigenous peoples, as past and present conditions leading to intergenerational trauma. Historical and present-day conditions affecting Aboriginal children and families are shown to set in place the conditions producing trauma over time.
Bank Kosa Kata Untuk Tuna Rungu dan Tuna Wicara Berbasis Web
Authors: Sari Ira Puspita , Salamun  , Sukri
Published: December 2021

Communication is the most important key to mastering this era of globalization. There is no denying that language is the most important part of communication. When one person uses the same language or understands another person's language, they can communicate well. Sign language is a language based on artificial communication, i.e. body language and lip movements during communication. This sign language is standardized as SIBI (Indonesian Sign Language System). SIBI is one of the media in the form of books that are able to communicate with deaf people in the community. Its shape is a systematic arrangement of groups of fingers, hands and various movements, symbolizing the word Indonesian. Book media does not seem to be easily understood by users, so it takes an application that can provide moving images to facilitate sign language learning, one of which is web-based.
Effects of Alpha-Tocopherol on Biochemical Parameters in Adult Mice
Authors: Kinsangou Franck Arnaud Moukobolo , Poaty Henriette , Mboungou Dimitry Moudiongui
Published: December 2021

Background: Numerous reviews report the beneficial effects of alpha tocopherol in preventive supplementation and also as an adjuvant in the treatment of some pathologies (cardiovascular, cancers). In this work, we analyzed the effects of vitamin E at high doses on some biochemical parameters.
Methods: Thirty-two adult male and female mice (CD1 albino mice) were randomly selected for a 4-week experiment. The mice were supplemented with alpha tocopherol at doses of 150, 400 and 750mg/day. With a high dietary intake of vitamin E
Results: According to our analyses, we can note Excess weight predominated in groups 4 to 7.
All the blood lipid parameters showed an abnormal concentration, as of the 400 mg dose of α-T-acetate.
Hyperglycemia and hyperlipidemia were observed. These variations were more pronounced for total cholesterol and triglycerides than for HDL and LDL fractions.
Conclusion: The study showed significant effects of high-dose α-T supplementation on biochemical parameters, mainly hyperglycemia and dyslipidemia.

Key words: Vitamin E, Alpha-tocopherol, blood biochemical parameters.
Nutritional Status and Physical Activity Pattern as Risk Factors for Non-Communicable Diseases among Occupational Bus Drivers
Authors: R Rashmi , H G Vidyavati , Manjunath C N
Published: December 2021

It is anticipated that occupational bus drivers are at risk of non-communicable diseases. Present study aims at assessing the nutritional status and analyzing the risk factors associated, which could increase the probability of non-communicable diseases among bus drivers and conductors working for Karnataka State Road Transport Corporation.120 professional drivers and conductors who attended annual health checkup were included. A pre designed questionnaire elicited information about anthropometry, dietary, physical activity and sleep pattern of the subjects. Lipid profile and blood glucose levels were recorded from annual health check up reports. Mean age of the subjects was 44 years with BMI ranging between 25- 29.9Kg/m2. 73.3% had mixed diet pattern, 40% skip their meals sometime and majority eat their meals outside home most of the days in a week.74.2% didn’t indulge in physical activity. 56.7% subjects slept six to seven hours per day. 17.5% were diabetic, 52.5%, 80.8% and 17.5%had higher serum triglycerides, Low Density Lipoprotein and total cholesterol respectively. 57.5% had lower High Density Lipoprotein levels. 8.3%, 21.7% and 15% were smokers, alcoholic and tobacco chewers respectively. ‘t’ test analysis showed significant difference between energy, protein and visible fat intake with that of Recommended Dietary Allowance and Estimated Average Requirement. Total cholesterol, Low Density Lipoprotein and serum triglycerides had positive correlation with energy, protein and visible fat intake and BMI. Considerable risk factors for non-communicable diseases were observed among the subjects; effective diet counseling with regular follow up and monitoring is necessary to prevent the same.

Key words: Occupational drivers, nutritional status, risk factors, dietary pattern, physical activity, Non Communicable Diseases, effective counseling.
Epidemiology of Musculoskeletal Disorders in Musicians - Systematic Review
Authors: Shinde Ketaki Vijay , Borkar Pradeep
Published: December 2021

Musicians performing over an instrument demands repetitive, awkward postures and postural stress from prolonged sitting or standing. Musicians are found to be more prone to the development of Playing-Related Musculoskeletal Disorders (PRMDs) due to these factors. PRMDs are defined as ‘pain, weakness, numbness, tingling or other symptoms that interfere with their ability to play an instrument’. There is an increasing interest seen in the medical issues faced by the musicians performing over an instrument. There are different type of musicians playing different instruments which means different instrumentalists face different musculoskeletal disorders depending upon many factors. There are intrinsic and extrinsic factors involved which contribute to the development of PRMDs in musicians. Development of PRMDs is seen to be a cause of early termination of musician’s career. The purpose of study is to review the epidemiology of musculoskeletal disorders in musicians.

Key words: Musculoskeletal disorders, Musculoskeletal problems, Prevalence of musculoskeletal injuries, Postural disorders, Playing-related strain in instrumentalists and musicians.
NUTRITIONAL QUALITY OF AWARA MADE FROM FERMENTED BANJARA BEANS AND SOYBEAN
Authors: Bintu P. B. , Falmata A. S. , Maryam B. K. , Nnenna R. O. , Hasina A. L. , Modu S.
Published: December 2021

Awara, a Nigerian soft cheese analogue produced from soy milk using crude coagulant of citric acid and alum. Soybean and banjara bean were used in this study and were evaluated for their proximate composition, mineral element content, antinutritional factors, in vitro protein digestibility and vitamin content using standard procedures. Results obtained indicated that fermented banjara bean awara had a protein content of 2.15±0.01%, and fermented soybean awara had a protein content of 3.75±0.01%. Fermented banjara beans awara and soybean awara had a fat content of 5.16±0.01% and 17.13±0.01% respectively. There were significant differences in the mineral element content of both non fermented and fermented banjara bean and soybean awara. Level of antinutritional factors showed that both tannin and phytic acid were absent in fermented soybean awara. The in vitro protein digestibility of non-fermented and fermented banjara bean and soybean awara significantly increases with time. Vitamin A contents of fermented banjara and soybean awara increased when compared to non-fermented banjara and soybean awara, while a decrease was observed in non-fermented banjara and soybean awara as compared to fermented banjara bean and soybean awara. It can be concluded from this study that fermented soybean awara which is free of antinutritional factors is a more suitable source of protein and fat as a local cheese in this part of the world.
Comparativa de los temas tratados por los principales partidos políticos y sus candidatos en Twitter y sus programas electorales. Análisis de las elecciones generales de 2016 en España
Authors: Iturregui Mardaras Leire , Cantalapiedra González María José , Elorriaga Illera Angeriñe , Caneda Portela Bruno
Published: December 2021

El presente estudio analiza el uso que los principales partidos políticos hacen de la red social Twitter en la campaña electoral correspondiente a las elecciones españolas generales del año 2016. Para ello se han seleccionado las cuentas de Twitter de los cuatro partidos que alcanzaron un 86% del porcentaje total de votos: el Partido Popular (PP), el Partido Socialista Obrero Español (PSOE), Unidas Podemos (UP) y Ciudadanos (C´s). Además, también se han tenido en cuenta las publicaciones de los respectivos candidatos de cada partido a la presidencia del gobierno y se han analizado los temas que tratan en esas publicaciones en Twitter, para compararlos con los temas que proponen en sus programas electorales. Los resultados de los 4.329 trinos (tweets) analizados demuestran la falta de coherencia entre los temas abordados en los trinos de partidos y candidatos, así como la ausencia de proporcionalidad en la importancia otorgada a las distintas cuestiones en el programa electoral. También se concluye que la modernidad adjudicada a los partidos de nueva creación no tiene como consecuencia una mayor actividad en la red social Twitter.
Rethinking General Education Program for Integrating Local Contexts and English Contents
Authors: Matchimo Puchong , Ekkapim Samarn , Janghan Surakan
Published: December 2021

The local and global dimensions are now in balance within the COVID-19 pandemic in all sectors, education needs to be adapted and disrupted for tomorrow. Local contexts in the stream of global movement concerns curriculum and instruction. The local contexts are significant content to promote English by various kinds of contents. This research purposes to study general education program for integrating local contexts and English contents. Target group consisted of teachers who have been taught basic English courses, general education program. The research tools used questionnaire and interviewing form to study the problems and needs for understanding the general education category by integrating content according to local context. As it finding, the local context is the authentic learning experiences that students can learn, they can make a link between local and global dimensions. Conceptual framework is proposed for rethinking genera; education program for integrating local and global English courses, the study needs more discussion how to help students develop learning abilities through the suitable curriculum and instructional practices.
RISK TAKING BEHAVIOR AS PREDICTORS OF SELF COMPASSION IN UNIVERSITY STUDENTS
Authors: Kıran Binnaz , Cengiz Özge
Published: December 2021

The present study was aimed at investigating to what extent self compassion of unıversıty students was predicted by their risk taking behavior sub-dimensions. The sample of study included 658 undergraduate students from different faculties of a public university during the 2018-2019 academic year. In order to collect the data in the study, Self Compassion Scale, Risk Behaviors Scale and Personal Information Form are used. Pearson product-moment correlation coefficient and multiple regression analysis were used in the analysis. The results of the study revealed the highest correlation between self compassion scores and suicidal tendency, which is one of the sub-dimensions of risk-taking behavior. In addition, it was found that together with the sub-dimensions of risk taking behavior, it explained 38.2% of the variance in self-compassion scores and It was found that the variable that most predicted self-compassion was suicidal tendency. Findings were discussed and interpreted in the light of literature.
THE SCALE OF DETERMINING THE PROBLEM BEHAVIORS OF CHILDREN IN PRESCHOOL PERIOD: A VALIDITY AND RELIABILITY STUDY
Authors: Keleş Oğuz , Emiroğlu Tuğba
Published: December 2021

This study was aimed to develop a scale to determine the problem behaviors of 3-6 aged preschool children. A systematic process was carried out during the development of the scale. A total of 305 preschool teachers filled in the scale development study. Based on the results of exploratory factor analysis (EFA), it was identified that the scale consists of 30 items and three factors, explaining 52.13% of the total variance. These factorsare named academic skills problems, peer relationship problems, and developmental-behavioral problems in accordance with the literature. Confirmatory factor analysis (CFA) was used to examine whether the collected data confirmed the determining factor structure. The whole scale’s Cronbach’s alpha reliability coefficient was found as .94. Cronbach alpha coefficients were .91 for “academic skills problems”, .89 for “peer relationships problems”, and .83 for “developmental behavior problems”. As a result of the analysis, the scale is valid and reliable to determine the problem behaviors of preschool children.
MICROTEACHING LESSON STUDY FOR PROSPECTIVE ENGLISH LANGUAGE TEACHERS: DESIGNING A RESEARCH LESSON
Authors: Coşkun Abdullah
Published: December 2021

In this study, Microteaching Lesson Study (hereafter MLS) was applied for a research lesson designed by the MLS group members including three third-year prospective English language teachers in line with the Content and Language Integrated Learning (hereafter CLIL) approach. This qualitative study aims to uncover the contribution of MLS to the improvement of the teaching within a single lesson geared toward young learners and the perspectives of MLS group members about major components of the MLS process. The participants of the study are three MLS group members, 15 peers and an instructor in the English Language Teaching (hereafter ELT) department of a state university in Turkey. The lesson collaboratively developed by the MLS group members was presented three times by a different member to a different group of five peers who pretended to be young learners. After each lesson, revision meetings were held to analyze the self-reflection of the presenter, the peer/instructor feedback about the lesson and the recorded lesson. The analysis of the revision meetings illustrated the instructional improvement cycle of MLS. Moreover, the analysis of the semi-structured interviews with the MLS group members revealed that they were generally satisfied with the major components of MLS, such as collaborative lesson planning and receiving feedback from peers although a few concerns were mentioned as well. It is suggested that MLS should be incorporated into ELT programs.
HOW RESPONSIBLE ARE TURKISH SECONDARY SCHOOL STUDENTS FOR DISTANCE LEARNING DURING THE COVID-19 PANDEMIC: A SCALE DEVELOPMENT AND IMPLEMENTATION STUDY
Authors: Yakar Ali
Published: December 2021

The purpose of the current study is to investigate the distance learning responsibility levels of secondary school students attending schools in the Aegean Region of Turkey by developing a scale of responsibility for distance learning. The study is a descriptive study employing the survey model. Two different study groups were used in the current study. In the first stage, a total of 477 secondary school students attending schools in the cities of İzmir, Denizli and Muğla in Turkey in the 2020-2021 school year were included in the study group to develop the Scale of Responsibility for Distance Learning. In the second stage of the study, the study group is comprised of 2043 secondary school students selected from among the secondary school students attending schools located in the cities of İzmir, Manisa, Aydın, Denizli, Muğla, Afyonkarahisar, Kütahya and Uşak in the Agean Region of Turkey in the 2020-2021 school year. The data were collected face-to-face and online via Google Forms during COVID-19 pandemic by using the Scale of Responsibility for Distance Learning. According to the findings of the study, the scale is a valid and reliable scale with adequately satisfied psychometric features. Another finding of the current study is that the participating secondary school students’ responsibility scores vary significantly depending on the city where they attend the school, grade level and gender.
COLLODIZING LINKS IN PRIVATE INTERNATIONAL LAW
Authors: Эриашвили Н.Д. , Сарбаев Г.М. , Федулов В.И.
Published: December 2021

В представленной статье рассмотрены проблемы коллодирующих привязок в международном частном праве и особенности их правовой регламентации в законодательстве Российской Федерации. Автором проанализированы особенности нормативного закрепления данного типа привязок в системе международных договоров, а также механизм имплементации этих норм в национальном законодательстве различных государств. На основе сложившейся практики применения коллодирующих привязок национальными органами государственной власти обоснована необходимость учета публичных интересов государства в данных правоотношениях.

The present article examines the problems of collodizing links in private international law and the peculiarities of their legal regulation in the legislation of the Russian Federation. The author analyzed the peculiarities of this type of binding in the system of international treaties, as well as the mechanism for implementing these norms in the national legislation of various states. On the basis of the established practice of applying collodial links by national authorities, the need to take into account the public interests of the State in these legal relations is justified.
Literature review of behavioral disorders after encephalic skull traumatisms
Authors: Brasileiro Maria Eduarda Galdino de Araújo , Almeida Bruna Barbosa de , Vieira Clara Campêlo Lucena , Ramalho Islany de Sousa Porto Diniz
Published: December 2021

Background: The traumatic brain injury (TBI) consists of a lesion in the skull region caused by an external force, which can cause sequelae in several clinical scenarios, with dysfunctions in the cognitive and behavioral spheres being one of the most disabling. These include: impaired memory, attention and concentration; slowing psychomotor speed and mental processing; in addition to personality changes. Objectives: To understand the relationship between short and long-term cognitive impairments caused by traumatic brain injuries. In addition to analyzing the repercussion that these sequels bring to the patient. Methods: This is a review of the literature in the PubMed, Scielo and UpToDate databases. Review articles, full texts, in the last 5 years, in humans were selected. Results: Patients affected by trauma have more prevalent cognitive impairments in the spheres of attention and concentration, processing speed, memory and executive function. The severity of neurocognitive impairments depends on a variety of factors, including: aspects in relation to brain injury such as its extent, location, severity of the trauma, as well as variables such as age and pre-morbid personality characteristics. Associated with the abovementioned alterations, biochemical alterations and accumulation of chronic neurotoxic proteins after TBI occur, which triggers biochemical processes of neurodegeneration in the long term. Conclusion: It’s clear that comprehensive neuropsychological assessments in each case of TBI are important to identify impaired and preserved functions, whether short or long term; thus allowing a better prognosis through rehabilitation programs and clinical and surgical therapeutic measures in emergency situations, usually involving fast decisions.
Analysis of Postural Control of Patients with Functional Impairment After Hospitalization for COVID-19
Authors: Godoy Caroline Gil de , Silva Érika Christina Gouveia e , Oliveira Danielle Brancolini de , Silva Elizabeth Mendes da , Gambeta Amislaine Cristina , Campos Camila Machado de , Carvalho Celso Ricardo Fernandes de , Schmitt Ana Carolina Basso , Fu Carolina , Nakagawa Naomi Kondo , Hill Keith , Pompeu José Eduardo
Published: December 2021

Background: Covid-19 associated with hospitalization results in damage to structures and body functions. Objective: Analyze the postural control of patients with functional loss after hospitalization by COVID-19. Design and setting: Prospective cohort study that evaluated patients after 1 month of discharge from Clinical Hospital - FMUSP, São Paulo, Brazil. Methodology: Functionality before and after hospitalization (Barthel Index), balance (Brief BalanceEvaluation Systems Test- BriefBESTest) and postural control (Static Posturography - Horus®Platform) were evaluated and divided into two groups: functional impairment (FI) and without functional impairment (WFI). Independent T test and Mann- Whitney were applicated for groups comparison (p=0.05). Result: 67 patients were evaluated. FI had 30 patients (44.7%) with a mean age of 62.8 (±10.7), 19 (63.3%) female and 11 (36.6%) male. WFI had 37 patients (55.2%) around average age of 57.7 (±11.6), 13 (35.1 %) female and 24 (64,8 %) male. There was a difference between groups in BriefBESTest (p=0.005) and the measurements of: trust ellipse (EC)-mm² and EC/Stability limit (LM) -% in Open eyes stable surface (OASE) (p=0.042 ; p=0.017), Open eyes unstable surface (OASI) (p=0.018; p=0.004) and Eyes closed unstable surface (OFSI) (p=0.004; p=0.002); Midlateral velocity (ML) in OASI (p=0.008); Functional residual balance in OASI (p=0.018) and OFSI (p=0.002); ML displacement and the anteroposterior of the maximum LM to the left (p=0.048; p=0.028). Conclusion: There is a difference between the FI and WFI groups regarding balance and postural control. It is suggested to include evaluations and targeted interventions for balance improvement and postural control after hospitalization by COVID-19.
Progressive Multifocal Leukoencephalopathy following Daratumumab therapy for refractory Multiple Myeloma – a case report
Authors: Borges Érico Induzzi , Fernandez André Lopez , Almeida Louis Fernando Marques de , Paes Juline do Prado , Bigonha Jandey da Glória , Rocha Antônio José da , Ribeiro Neto Herval Soares , Silva Sônia Maria Cesar de Azevedo
Published: December 2021

Context: PML is a dymyeliniating disease of the brain, caused by JC virus infection reactivation in immunocompromised patients, especially by AIDS, hematological disease and immunosuppressive therapies. Case report: A 67-year-old woman was diagnosed with multiple myeloma (MM) in 2018 and use of bortezomib/cyclophosphamide/dexamethasone and thalidomide was ineffective. She underwent treatment with monthly daratumumab starting in January 2020. After one year, she experienced progressive amnesia, apathy and confusion. At admission, examination revealed apathy, monosyllabic communication and frontal release, progressing to mutism and abulia. T2 FLAIR-weighted MRI of the brain performed in March 2021 showed a hyperintense non-enhancing lesion affecting thalamus, internal capsule, lentiform and deep white matter of left lobes. MRI performed one month before symptoms onset showed a small lesion in subinsular region – indicating incipient involvement. Cerebrospinal fluid PCR was positive for JC viruses, and PML was diagnosed. Conclusions: This report proves that concomitant hematologic and drug- immunocompromised patients presenting with neurological symptoms should be investigated for PML. There are few reports in the literature of PML occurring in MM, especially after use of daratumumab, an anti-CD38 monoclonal antibody. Recently, one small case series demonstrated some improvement in pembrolizumab (a checkpoint inhibitor)-treated PML, but no routinely therapy is recommended. Understanding severity of both disease, patient was discharged receiving conservative treatment.
Deep brain stimulation in the treatment of Parkinson’s disease
Authors: Rocha Bruna Alves , Braga Lucas Oliveira , Nascimento Julia Beatriz Xavier do , Avakian Angela dos Santos
Published: December 2021

Introduction: Parkinson’s disease (PD) is neurodegenerative and has bradykinesia, rest tremor, stiffnes and postural instability. These changes come from the degeneration of dopaminergic neurons. The treatment, carried out based on levodopa, provides improvements in the condition of the patients, however, they provide side effects. Based on this, the Deep Brain Stimulation (DBS) technique - stimulation of subcortical structures with electrodes - is a good treatment option. Methods: A narrative review of the literature was carried out, using the PubMed database with the keywords “Deep brain stimulation”, “Therapeutic use” and “Parkinson’s disease”. Included articles of meta-analysis, systematic review and review published in the last year. Results: The DBS offers a significant improvement in motor symptoms, gait, postural instability, reduction in tremors and in their progression. However, DBS can offer risks to the patient. Comparing the effectiveness of DBS with other therapies for Parkinson’s, such as levodopa/ carbidopa intestinal infusion gel (LCIG) and best medical therapy (BMT), it was found that BMT is botton. The cost-effectiveness comparison of these techniques, showed that DBS is the most costly procedure. It stands out comparisons can have intrinsic biases, such as the conflict of interest with pharmaceutical companies. Conclusion: DBS is a beneficial intervention for patients with PD who have important motor symptoms. Performed only in cases with indication, due to the possibility of complications.
HINTS protocole and it’s accuracy to identify posterior circulation stroke: a review
Authors: Loureiro Eduardo Sales , Felippe Luna Vasconcelos , Guimarães Ana Luiza Cotta Mourão , Costa Anna Carolina Dockhorn de Menezes Carvalho
Published: December 2021

Introduction: The HINTS protocol is important to differentiate peripheral from central vertigo in Acute Vestibular Syndrome (AVS). There are studies that show almost 1/3 of patients have posterior circulation stroke. It is important to investigate why this happens. Objectives: Review the accuracy of HINTS test in the diagnosis of posterior circulation stroke. Methods: Review conducted in PubMed using key words “HINTS AND ACCURACY AND STROKE”. The search found 9 articles, 7 of which were included. Results: Tehrani et al. (2014) studied HINTS’s accuracy when associated with hearing loss, resulting on a bigger accuracy than MRI. Newman- Toker et al. (2013) found that HINTS score was superior than ABCD2 in identifying AVS caused by stroke. From Carmona et al. (2016), HINTS had 100 % sensibility and 94,4% specificity and emphasized ataxia evaluation’s importance, once all patients with central etiology had a grade of ataxia. Krishnan et al. (2019) HINTS had 59,9% Negative Predictive Value (NPV) and 97,2 % Positive Predictive Value (PPV) related to stroke, same PPV was found by Sankalia et al. (2021). Ohle et al. (2020) observed that HINTS done by a neurologist was more accurate than studies that mixed neurologists and emergency physicians. Dmitriew et al. (2021) saw that HINTS was used wrongly in non-specific emergency departments, once only 3,1% patients tested had AVS and 96,9% wrongly tested had false positives. Conclusion: The HINTS is a valuable instrument in the clinical use and the training for better practical application needs incentive in emergency departments.
Neurological repercussions after COVID-19 in a young pregnant patient: a case report
Authors: Reis Mateus Fernandes Alves dos , Ribeiro Lavínia Ayumi Borges , Mota Mariana de Oliveira Andrade , Borges Stella Bianchini , Pardi Guilherme Rocha
Published: December 2021

Context: Most patients with COVID-19 have mild respiratory disease, however, neurological manifestations have also been associated. Case report: Female, 21 years old, 24 weeks pregnant, admitted with severe acute respiratory distress syndrome, by COVID-19. Evolved with respiratory failure. On the 14th day of hospitalization, fetal death occurred. After clinical stabilization, she started neurological symptoms, with altered state of consciousness, delusions, tremor in extremities, paresis in right dimidium and paresthesia in extremities. Nuclear magnetic resonance imaging showed numerous old micro- hemorrhagic foci, complemented with angio resonance and inflammatory activity evaluation, with embolic event and vasculitis ruled out. Electroneuromyography showed multiple mononeuritis. She recovered gradually, maintaining the tremor in extremities. Conclusions: Neurological manifestations can occur both by viral cytopathic action and by systemic complications resulting from immunomediated phenomena. In a study carried out in the United Kingdom, by Varatharaj et al, with 125 patients with COVID-19 and neuropsychiatric disorders, the most observed conditions were cerebrovascular event (62%), altered mental status (31%), both present in the case and, in addition, encephalopathy (23%) and encephalitis (18%). The neurological manifestations observed in COVID-19 can affect both the central and the peripheral nervous system. This patient has multiple mononeuropathy, characterized by the involvement of two or more peripheral nerve trunks, with motor and sensory manifestations.
Brain functional network alterations in patients with asymptomatic carotid disease
Authors: Sacho Isabella Batistela Inhesta , Tamanini João Vitor Gerdulli , Campos Brunno Machado , Silva Danilo Santos , Coan Ana Carolina , Avelar Wagner Mauad
Published: December 2021

Background: The best therapeutic approach to asymptomatic carotid stenosis (ACS) is still subject to discussion. Previous studies have agreed on the findings that ACS patients present with cerebral atrophy and cognitive decline compared to healthy controls. The present study aims to identify possible alterations in the brain functional network of such patients. Objectives: Study alternations in the connectivity of the Default Mode Network (DNM) in patients with ACS of at least 70%, compared to controls. Design and Setting: A cross-sectional case-control study was carried out at the Neuroimaging Laboratory at Hospital das Clínicas, Universidade Estadual de Campinas (UNICAMP) - Campinas, São Paulo (Brazil). Methods: Two groups of 15 individuals matched by sex and age, the first composed ACS patients with stenosis and the second of healthy volunteers, were submitted to 3 Tesla magnetic resonance imaging. The images were analyzed using Statistical Parametric Mapping 12 and UF2C User Friendly Functional Connectivity Toolbox software. All patients signed the Informed Consent Form. Results: ACS patients were 13 men and 2 women with an average age of 72 years. Regarding DMN connectivity, the control presented higher activity, particularly in the medial segment of the superior frontal gyrus. Conclusion: ACS patients with stenosis higher than 70% displayed prejudiced cerebral connectivity compared to healthy controls.
Benef﻿icial effects of combined rTMS and physical rehabilitation for spasticity in multiple sclerosis
Authors: Farias Frederico Arriaga Criscuoli de , Dagostini Carolina Matté , Moro Carolina Dalla Santa Dal , Nunes Carolina Odorizzi Magno , Rizzolli Mariana Moreira , Roxo Marcelo R.
Published: December 2021

Background: spasticity affects up to 90% of multiple sclerosis (MS) patients, being a major cause of disability. Repetitive transcranial magnetic stimulation (rTMS) appears to be a potential treatment, but literature is scarce. Objectives: to evaluate the effects of combined rTMS and physical therapy for spasticity in MS patients. Methods: relapsing-remitting MS patients suffering from lower limb spasticity were included. The rTMS protocol consisted of 20 sessions of 18 trains of 50 stimuli at 5Hz and at 100% of rest potential threshold, with 10 seconds per train and 40 second pauses, amounting for 900 pulses (15 minutes) with a Neurosoft- MS/D double coil. Optimal coil positioning was determined by motor responses in the contralateral soleus muscle. The physical therapy protocol included active exercising – stationary bicycle, step climbing with partial weight suspension – followed by mild gradual resistance exercising for knee extension and hip and foot flexion, proprioceptive exercises and active stretching. The primary outcome was improvement on the Modified Ashworth Scale (MAS) score at baseline and 4 weeks after treatment. Results: five female patients were recruited. At the 4-week follow-up, 4 out the 5 patients had a significant improvement regarding spasticity. There was a reduction in mean MAS score from 2.30 to 1.42. Patient 1 had a MAS score reduction from 2 to 1 (50%). Patient 2 from 3 to 1 (66%), patient 3 from 4 to 3 (25%) and patient 4 from 0.5 to 0.125 (75%). Conclusion: combined rTMS and physical therapy protocols presents as a beneficial treatment modality for MS spasticity.
Clinical-epidemiological profile of the patient hospitalized with Dementia in the state of São Paulo
Authors: Costa Matheus Gomes Reis , Andrade Victor Bertani , Menezes Carla Jamile Jabar
Published: December 2021

Background: Dementia syndromes have a progressive and varied nature, causing cognitive and functional decay. Therefore, understanding the epidemiology of this disease is important for its screening. Objectives: To present the patients hospitalized in the state of São Paulo clinical-epidemiological profile, between March 2011 and February 2021. Design and settings: Descriptive, retrospective, and quantitative epidemiological study. Methodology: The data were collected in Sistema de Informação Hospitalares do Sistema Único de Saúde. The number of hospitalizations and mortality rate were analyzed, correlating them with sex, color, age group, care type, and year. Results: In 6572 hospitalizations, there was no sex majority. 20.3% of the patients did not present information about color. Among the identified, the majority was white (66.2%) or brown (24.7%). Individuals older than 60 years represented 62.6%, with peak between 70 and 79 years old. White population had the highest mortality rates (7.85 ‰), followed by the black population (7.55 ‰). The mortality rate was higher among women older than 80 years. Mortality in elective care (11.6 ‰) was approximately 4 times higher than in emergency care (2.77 ‰). Conclusions: The profile includes white and brown population, older than 60 years. Higher mortality rates in women older than 80 years may be related to their longer life expectancy. Higher mortality in elective care may indicate greater neurodegenerative diseases presence.
Internal Carotid Artery Dissection during Puerperium: A Case Report
Authors: Bernardes Leonardo de Sousa , Barreira Raphael Palomo , Marques Marina Trombin , Reges Danyelle Sadala , Gagliardi Vivian Dias Baptista , Gagliardi Rubens José
Published: December 2021

Background: Carotid or vertebral artery dissection is a rare puerperium event, occurring in less than 6% of cases. Although physiopathology is not completely understood, it is probably multifactorial involving increased cardiac output, hypervolemia and hormonal changes remodeling endothelium and favoring dissection. Most patients present headache and neck pain, but it is also reported Horner syndrome, tinnitus, retroorbital pain and cranial nerve palsies. Case Report: Female, 39-year-old patient in the 20th day of puerperium presents a sudden headache with transitory left hemiparesis and dysarthria for 30 minutes. Magnetic Resonance Imaging (MRI) with angioresonance revealed an area of right middle cerebral artery (MCA) infarction and right internal carotid artery dissection in the cervical segment with a large intraluminal thrombus. The diagnosis was stablished as ischemic stroke caused by carotid dissection. Transcranial doppler presented post stenotic flow in the right MCA, flow inversion in the right anterior cerebral artery (ACA) and ipsilateral collateral circulation of the external carotid artery. After two months on double antiplatelet treatment (apirin 100mg and clopidogrel 75mg), it was partially recanalized and there was improvement in the collateral and hemodynamic pattern. Conclusion: Puerperium pacients describing intense headache or neck pain should be investigated with MRI and angioresonance of intracranial and cervical vessels. In the cervical arterial dissection it is recommended double antiplatelet therapy, for three to six months.
The heart of myofibrillary myopathy
Authors: Athayde Natália Merten , Carvalho Alzira Alves de Siqueira
Published: December 2021

Context: Myofibrillar myopathies (MFM) represent a heterogeneous group of disorders of skeletal and cardiac muscle caused by mutations in genes that encode proteins of sarcomere. Diagnosis is a challenge due to clinical and genetic variability. Case report: Woman, 36 years old, presenting stumbles and falls for 3 years evolving with proximal limb weakness. At age 30, she fainted and a cardiac pacemaker was implanted. Non-consanguineous parents. Neurological exam: proximal and distal weakness in lower limbs and distal atrophy; osteotendinous reflexes normal. Bilateral scapula alata. Exams: CPK = 457 U / l; EMG: myopathic pattern. Muscle MRI: diffuse and heterogeneous fatty degeneration, marked in sartorius, gracilis and semitedinous. Panel NGS myopathies: pathogenic variant, c.1175T> C, missense in heterozygosis in desmin gene. CONCLUSION: The diagnosis of MFM is based on the morphological findings of muscle biopsy with the presence of protein aggregates as a determining factor. Currently, genetic testing by NGS has facilitated early diagnosis allowing for a more appropriate clinical approach. The desmin gene was the first one described to be associated with this group of myopathies. It encodes the desmin protein, a member of the intermediate filament family present in cardiac and skeletal muscle. Several phenotypes are related to desmin gene: isolated dilated cardiomyopathy; scapuloperoneal weakness and distoproximal weakness with cardiac alterations. Desminopathy is a rare cause of cardiomyopathy and / or myopathy. The diagnosis should be thought in patient with muscle weakness and cardiac changes.