bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of quality of care of patients with ST-segment elevation myocardial infarction
Authors: Hudzik Bartosz , Budaj Andrzej , Gierlotka Marek , Witkowski Adam , Wojakowski Wojciech , Zdrojewski Tomasz , Gil Robert , Legutko Jacek , Bartuś Stanisław , Buszman Paweł , Dudek Dariusz , Gąsior Mariusz
Published: November 2019

Aims:

The 2017 European Society of Cardiology guidelines for the management of ST-elevation myocardial infarction recommended assessing quality of care to establish measurable quality indicators in order to ensure that every ST-elevation myocardial infarction patient receives the best possible care. We investigated the quality indicators of healthcare services in Poland provided to ST-elevation myocardial infarction patients.

Methods and results:

The Polish Registry of Acute Coronary Syndromes is a nationwide, multicentre, prospective study of acute coronary syndrome patients in Poland. For the purpose of assessing quality indicators, we included 8279 patients from the Polish Registry of Acute Coronary Syndromes hospitalised with ST-elevation myocardial infarction in 2018. Four hundred and eight of 8279 patients (4.9%) arrived at percutaneous coronary intervention centre by self-transport, 4791 (57.9%) arrived at percutaneous coronary intervention centre by direct emergency medical system transport, and 2900 (37.2%) were transferred from non-percutaneous coronary intervention facilities. Whilst 95.1% of ST-elevation myocardial infarction patients arriving in the first 12 h received reperfusion therapy, the rates of timely reperfusion were much lower (ranging from 39.4% to 55.0% for various ST-elevation myocardial infarction pathways). The median left ventricular ejection fraction was 46% and was assessed before discharge in 86.0% of patients. Four hundred and eighty-nine of 8279 patients (5.9%) died during hospital stay. Optimal medical therapy is prescribed in 50–85% of patients depending on various clinical settings. Only one in two ST-elevation myocardial infarction patients is enrolled in a cardiac rehabilitation program at discharge. No patient-reported outcomes were recorded in the Polish Registry of Acute Coronary Syndromes.

Conclusions:

The results of this study identified areas of healthcare system that require solid improvement. These include direct transport to percutaneous coronary intervention centre, timely reperfusion, guidelines-based medical therapy (in particular in patients with heart failure), referral to cardiac rehabilitation/secondary prevention programs. Also, there is a need for recording quality indicators associated with patient-reported outcomes.
Prioritizing candidate diseases-related metabolites based on literature and functional similarity
Authors: Wang Yongtian , Juan Liran , Peng Jiajie , Zang Tianyi , Wang Yadong
Published: November 2019

Background

As the terminal products of cellular regulatory process, functional related metabolites have a close relationship with complex diseases, and are often associated with the same or similar diseases. Therefore, identification of disease related metabolites play a critical role in understanding comprehensively pathogenesis of disease, aiming at improving the clinical medicine. Considering that a large number of metabolic markers of diseases need to be explored, we propose a computational model to identify potential disease-related metabolites based on functional relationships and scores of referred literatures between metabolites. First, obtaining associations between metabolites and diseases from the Human Metabolome database, we calculate the similarities of metabolites based on modified recommendation strategy of collaborative filtering utilizing the similarities between diseases. Next, a disease-associated metabolite network (DMN) is built with similarities between metabolites as weight. To improve the ability of identifying disease-related metabolites, we introduce scores of text mining from the existing database of chemicals and proteins into DMN and build a new disease-associated metabolite network (FLDMN) by fusing functional associations and scores of literatures. Finally, we utilize random walking with restart (RWR) in this network to predict candidate metabolites related to diseases.

Results

We construct the disease-associated metabolite network and its improved network (FLDMN) with 245 diseases, 587 metabolites and 28,715 disease-metabolite associations. Subsequently, we extract training sets and testing sets from two different versions of the Human Metabolome database and assess the performance of DMN and FLDMN on 19 diseases, respectively. As a result, the average AUC (area under the receiver operating characteristic curve) of DMN is 64.35%. As a further improved network, FLDMN is proven to be successful in predicting potential metabolic signatures for 19 diseases with an average AUC value of 76.03%.

Conclusion

In this paper, a computational model is proposed for exploring metabolite-disease pairs and has good performance in predicting potential metabolites related to diseases through adequate validation. This result suggests that integrating literature and functional associations can be an effective way to construct disease associated metabolite network for prioritizing candidate diseases-related metabolites.
Extracting a biologically latent space of lung cancer epigenetics with variational autoencoders
Authors: Wang Zhenxing , Wang Yadong
Published: November 2019

Background

Lung cancer is one of the most malignant tumors, causing over 1,000,000 deaths each year worldwide. Deep learning has brought success in many domains in recent years. DNA methylation, an epigenetic factor, is used for model training in many studies. There is an opportunity for deep learning methods to analyze the lung cancer epigenetic data to determine their subtypes for appropriate treatment.

Results

Here, we employ variational autoencoders (VAEs), an unsupervised deep learning framework, on 450K DNA methylation data of TCGA-LUAD and TCGA-LUSC to learn latent representations of the DNA methylation landscape. We extract a biologically relevant latent space of LUAD and LUSC samples. It is showed that the bivariate classifiers on the further compressed latent features could classify the subtypes accurately. Through clustering of methylation-based latent space features, we demonstrate that the VAEs can capture differential methylation patterns about subtypes of lung cancer.

Conclusions

VAEs can distinguish the original subtypes from manually mixed methylation data frame with the encoded features of latent space. Further applications about VAEs should focus on fine-grained subtypes identification for precision medicine.
Oral adherence in adults with acute myeloid leukemia (AML): Results of a mixed methods study.
Authors: Bryant Ashley Leak , LeBlanc Thomas William , Albrecht Tara A. , Chan Ya-Ning , Richardson Jaime , Foster Matthew C. , Dang Malisa , Owenby Susie , Wujcik Debra
Published: November 2019

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Background: The incidence of AML is increasing, in part due to an aging population. Amid established intravenous (IV) or subcutaneous chemotherapies , recent drug approvals have ushered in an era of oral medication (OM) approaches to treating AML, shifting the burden of daily adherence from clinicians to patients. We aimed to identify and summarize adherence to oral therapy in this population. Methods: Our mixed methods study design used focus groups (FG) and patient surveys. After IRB approval, 11 patients and 4 caregivers participated in 4 focus groups. Results were used to develop a 37-item OM adherence needs assessment. Subsequently, AML patients were recruited and consented at three cancer centers to complete surveys (online, at the clinic, hospital, or from home). Results: 100 patients completed the OM survey. Most were male (62%), racial/ethnic diversity (33%), < 65 years (59%), and college-educated (52%). The to be taken was the most frequent and troublesome challenge. Loss of appetite was the most commonly reported and problematic side effect. Although half of the patients stated, “no side effect would cause them to stop taking OM”, another 25% indicated nausea would cause non-adherence. The best strategy to support taking OM was to make it part of the daily routine. Directions for taking OM were most commonly found on medication bottles or received from the health care team (HCT); patients felt HCTs were the best source of directions. Nearly 1/3 of patients indicated they skip the OM dose altogether when they forget to take it. When asked what would help improve adherence: smaller pills, easier packaging, and scheduling assistance were most frequently reported. Older individuals (>65 years) had a slightly more positive attitude towards oral medication (p =.51). Younger patients (<65 years) were more accepting of taking oral vs IV meds, (p = .03). Conclusions: This study represents the first assessment of OM adherence in patients with AML. Three themes emerged in FG transcript analysis that informed the development of a 37-item survey that was subsequently completed by 100 patients. Findings provide the basis for further exploration of interventions to enhance and increase adherence to OM regimens.
Anxiety, depression, pain, and social support in a large representative cancer population.
Authors: Galloway Sarah Kathryn , Meadors Patrick , Boselli Danielle , Walsh Declan
Published: November 2019

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Background: Pain is one of the most common cancer symptoms. Individuals in pain often experience psychological distress in the form of anxiety and depression. Social support is an important resource utilized by patients to cope with cancer. Aims: (1) Identify clinicodemographic factors influencing cancer pain; (2) examine social support as a moderator of the relation between anxiety, depression and cancer pain. Methods: Participants included stage I-IV cancer patients (N = 11,815) who completed a routine tablet-based psychosocial distress screening at a large academic hybrid, multi-site, community-based cancer institute (Jan 2017- Jan 2019). Participants were matched to the Cancer Registry (N = 7,333); clinicodemographic factors were incorporated into lasso regression models. Models identified pain predictors from self-reported anxiety, depression and social support. Analyses examined if the effect of anxiety and depression on pain differed by levels of social support. Results: Median age was 59 (RNG, 18-101), 61% female and 77% white. Tumor site (GI, Gyn, head/neck), advanced disease, black race, and lower income were independently associated with severe pain. Anxiety (β = 0.48, p < .001) and depression (β = 0.69, p < 0.001) were related to pain intensity after accounting for clinicodemographic factors. The effect of depression on pain differed by level of social support (p = 0.009). The effect of anxiety on pain differed in patients reporting transportation issues (p = 0.035). Conclusions: This is the largest study to date examining cancer pain intensity, psychological factors of anxiety and depression, and social support. Our data suggests that patient characteristics of race, income, tumor site, and disease staging independently predict pain intensity. Anxiety and depression are significant factors of pain intensity; these associations remain after accounting for patient characteristics. Social support buffers the negative impact of anxiety/depression on pain. Clinicians who treat cancer pain should be attuned to modifiable psychological factors which can greatly influence a patient’s pain experience. Findings emphasize the need for interdisciplinary multimodal approaches for cancer pain.
Sleep Deprivation: Cytokine and Neuroendocrine Effects on Perception of Effort
Authors: CULLEN TOM , THOMAS GAVIN , WADLEY ALEX J.
Published: November 2019

Introduction

An increased perception of effort and subjective fatigue are thought to be central to decreased exercise performance observed after disrupted sleep. However, there is limited understanding of mechanisms that underpin these phenomena. We investigated the role of interleukin-6 (IL-6), the soluble IL-6 receptor, and neuroendocrine factors (cortisol, adrenaline, noradrenaline, and brain-derived neurotropic factor) in mediating these responses at rest and during exercise.

Methods

In a randomized order, 10 healthy active men completed three experimental trials following different sleep conditions: a single night of sleep deprivation, partial sleep deprivation equivalent to 4 h of sleep, and normal sleep. The experimental sessions consisted of physiological and perceptual measurements of exercise intensity throughout 45-min moderate intensity and 15-min maximal effort cycling. Cytokine and neuroendocrine factors were assessed at rest and in response to exercise.

Results

Sleep deprivation resulted in increased resting IL-6, lower blood glucose, increased perceived fatigue and perception of effort, lower free-living energy expenditure, and reduced maximal exercise performance. In contrast, sleep deprivation did not alter physiological, cytokine, or neuroendocrine responses to exercise. Variations in the resting concentration of IL-6 were associated with lowered blood glucose, an increased perception of effort, and impaired exercise performance. Resting concentrations of cortisol, adrenaline, noradrenaline, and BNDF showed subtle interactions with specific aspects of mood status and performance but were not affected by sleep deprivation. There were minimal effects of partial sleep deprivation.

Conclusions

These findings demonstrate that cytokine and neuroendocrine responses to exercise are not altered by sleep deprivation but that changes in the resting concentration of IL-6 may play a role in altered perception of effort in this context.
PERKEMBANGAN, PRODUKSI, DAN PERAN KULTUR MIKROALGA LAUT DALAM INDUSTRI
Authors: Noerdjito Diah Radini
Published: November 2019

DEVELOPMENT, PRODUCTION, AND THE ROLE OF MARINE MICROALGA IN INDUSTRY. Microalgae cultures recently have been used for various purposes. Culture development of microalgae started from the late 1800s and still continue until now. Specific media composition, lighting, aeration, culture system were applied to many different species microalgae for specific purposes such as pharmaceutical, healthcare, cosmetics, environmental management, energy production, and aquaculture.
Somatostatin analog challenge test in the pre-surgical management of ACTH-secreting pheochromocytoma
Authors: Rossini Alessandro , Perticone Francesca , Frosio Laura , Schiavo Lena Marco , Lanzi Roberto
Published: November 2019

ACTH-secreting pheochromocytoma is a very rare cause of Cushing’s syndrome, with a high morbidity and mortality risk due to both cortisol and catecholamines excess. We report the case of a 45-year-old female patient with a 3 cm, high-density, left adrenal mass, diagnosed as an ACTH-secreting pheochromocytoma. The biochemical sensitivity of the tumor to somatostatin analogues was tested by a 100 μg s.c. octreotide administration, which led to an ACTH and cortisol reduction of 50 and 25% respectively. In addition to alpha and beta blockers, preoperative approach to laparoscopic adrenalectomy included octreotide, a somatostatin analogue, together with ketoconazole, in order to achieve an adequate pre-surgical control of cortisol release. Histopathological assessment confirmed an ACTH-secreting pheochromocytoma expressing type 2 and 5 somatostatin receptors (SSTR-2 and -5).

Learning points:

ACTH-secreting pheochromocytomas represent a rare and severe condition, characterized by high morbidity and mortality risk.

Surgical removal of the adrenal mass is the gold standard treatment, but adequate medical therapy is required preoperatively to improve the surgical outcome and to avoid major complications.

Somatostatin analogs, in addition to other medications, may represent a useful therapeutic option for the presurgical management of selected patients.

In this sense, the octreotide challenge test is a useful tool to predict favorable therapeutic response to the treatment.
CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice
Authors: Liu Jiali , Li Yue , Zhou Xiaoyan , Zhang Xi , Meng Hao , Liu Sanyuan , Zhang Lei , He Juntao , He Qian , Geng Yan
Published: November 2019

High-fat diet (HFD) not only induces insulin resistance in liver, but also causes autophagic imbalance and metabolic disorders, increases chronic inflammatory response and induces mitochondrial dysfunction. Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has recently emerged as an important regulator of glucose metabolism and skeletal muscle insulin action. Its activation has been involved in the improvement of hepatic and adipose insulin action. But the underlying mechanism is not fully understood. In the present study, we aimed to address the direct effects of CaMKIV in vivo and to evaluate the potential interaction of impaired insulin sensitivity and autophagic disorders in hepatic insulin resistance. Our results indicated obese mice receiving CaMKIV showed decreased blood glucose and serum insulin and improved insulin sensitivity as well as increased glucose tolerance compared with vehicle injection. Meanwhile, defective hepatic autophagy activity, impaired insulin signaling, increased inflammatory response and mitochondrial dysfunction in liver tissues which are induced by high-fat diet were also effectively alleviated by injection of CaMKIV. Consistent with these results, the addition of CaMKIV to the culture medium of BNL cl.2 hepatocytes markedly restored palmitate-induced hepatic insulin resistance and autophagic imbalance. These effects were nullified by blockade of cyclic AMP response element-binding protein (CREB), indicating the causative role of CREB in action of CaMKIV. Our findings suggested that CaMKIV restores hepatic autophagic imbalance and improves impaired insulin sensitivity via phosphorylated CREB signaling pathway, which may offer novel opportunities for treatment of obesity and diabetes.
Análisis de la relación existente entre la oferta académica de las universidades costarricenses en el ámbito de los negocios, y su demanda laboral
Authors: Cabrera Ramírez Mónica Karina , Chaves Martínez José Carlos , Flores Alvarado Sebastián , Gamboa Flores Gloria
Published: November 2019

La siguiente investigación tiene como propósito presentar un estudio de la oferta académica y la demanda laboral para la carrera de Administración de Negocios en Costa Rica. ¿Ofrecen las universidades a sus estudiantes las herramientas necesarias para satisfacer las demandas del mercado? Como metodología, se creó un índice que vincula la demanda laboral con la oferta académica, por medio de una nota que determina la compatibilidad de cada universidad y las posiciona. Para analizar la oferta académica, se tomaron todos los planes de estudio de las carreras acreditadas ante el Sinaes y se analizaron y dividieron en dos áreas: básica y complementaria. Con respecto a la demanda, se realizó un censo basado en el top cuarenta de las mejores empresas para trabajar, según Great Place to Work 2018, en el cual se preguntaba sobre las aptitudes y actitudes que buscan al reclutar. El índice arrojó notas entre 30.48 hasta 56.68, posicionando a la Universidad de Costa Rica en el cuarto lugar.
La fiscalidad ambiental: auditoría a la gestión de las oficinas tributarias de los municipios de El Doncello y El Paujil en el Caquetá
Authors: Tovar Cardozo Ginna , Restrepo Lizcano John Jairo
Published: November 2019

Los municipios tienen una gran responsabilidad frente a la gestión ambiental en virtud de su política tributaria, en especial por la administración de tributos con alguna incidencia ambiental, entre ellos los impuestos de publicidad exterior visual, sobretasa ambiental, delineación urbana, uso del espacio público y el de circulación y tránsito. Cada uno de ellos tiene una justificación en el ingreso, pero puede convertirse en una herramienta poderosa para desincentivar el consumo o corregir acciones del ciudadano, que sin pretenderlo terminan por fomentar el daño ambiental. La investigación realizada se centró en evaluar, en primer lugar, la estructura organizacional de las oficinas tributarias de los municipios de El Paujil y El Doncello, del departamento del Caquetá (Colombia) y, en segundo lugar, la legalidad y conveniencia de aplicar o crear impuestos relacionados con el derecho que tienen los ciudadanos a un ambiente sano. Se realizó una investigación mixta a través de técnicas cualitativas y cuantitativas, utilizando como instrumentos la aplicación de listas de chequeo y encuestas a funcionarios, así como revisión de fuentes normativas reguladoras de los tributos en cada municipio. Los resultados dan cuenta de la existencia de falencias relacionadas con los procesos de determinación, fiscalización, liquidación y cobro coactivo de los tributos municipales, a partir de su estructura organizacional.
Distortions introduced by normalisation of values of criteria in multiple criteria methods of evaluation
Authors: Podviezko Askoldas
Published: November 2019

Quantitative multiple criteria decision aid (MCDA) methods of evaluation gain increasing popularity among researchers. The idea of the methods is to comprise values ofcriteria characterising each object into a single non-dimensional cumulative criterion, which reflects attractiveness or position of the object in view of an objective chosen. Normalisation of weights is a compulsory procedure whenever criteria of different dimensions are present. There several methods of  normalisation available. Nevertheless, each method may introduce distortions into transformed data. The paper is devoted to exploration of problems related to such distortions and reveals particular cases.
Hierarchical Bayesian reliability assessment of energy networks
Authors: Iešmantas Tomas , Alzbutas Robertas
Published: November 2019

It is often the case that data used for the systems reliability assessment comes from more than one information source. Whether they are power plants at different geographical locations, gas transmission pipelines operating in different environment or power transmission networks deployed within various areas. Therefore, different operating conditions, varying maintenance programs and efficiencies have its share in influencing the vulnerability and variability of reliability data. However, in practice it is usually the case that this heterogeneity is neglected leading to the underestimation of underlying uncertainty of the data. Bayesian models are capable of dealing with this kind of uncertainty as opposedto the frequentists statistical methods. Hierarchical Bayesian modelling technique provides means to quantify not only within-source, but also between-source uncertainties. Even in the case of small data samples it performs well, unlike for example the classical likelihood method which may provide degenerate estimates. In this paper authors investigate the possibility to incorporate this kind of uncertainty into the systems reliability and vulnerability assessment through the Bayesian framework in several cases: gas transmission networks and power transmission grids.
Application of spatial classification rules for remotely sensed images
Authors: Stabingis Giedrius , Stabingienė Lijana
Published: November 2019

In this paper the remote sensed image classification example using spacial classification rule with distance (SCRD) is examined. This supervised classification method was first presented in paper [11]. This method is improved version of earlier method PBDF [4, 10, 9], during the classification it incorporates more spatial information. The advantage of this method is its ability to classify data which is corrupted by Gaussian random field and it is typical to remotely sensed images classified in this letter which are corrupted by clouds. Classification accuracy is compared with earlier method and with other commonly used supervised classification methods.
Aluminum Effects in Infants and Children
Authors: Corkins Mark R. ,   COMMITTEE ON NUTRITION, Abrams Steven A. , Fuchs George J. , Goday Praveen S. , Hannon Tamara S. , Kim Jae H. , Lindsey C. Wesley , Rome Ellen S.
Published: November 2019

Aluminum has no known biological function; however, it is a contaminant present in most foods and medications. Aluminum is excreted by the renal system, and patients with renal diseases should avoid aluminum-containing medications. Studies demonstrating long-term toxicity from the aluminum content in parenteral nutrition components led the US Food and Drug Administration to implement rules for these solutions. Large-volume ingredients were required to reduce the aluminum concentration, and small-volume components were required to be labeled with the aluminum concentration. Despite these rules, the total aluminum concentration from some components continues to be above the recommended final concentration. The concerns about toxicity from the aluminum present in infant formulas and antiperspirants have not been substantiated but require more research. Aluminum is one of the most effective adjuvants used in vaccines, and a large number of studies have documented minimal adverse effects from this use. Long-term, high-concentration exposure to aluminum has been linked in meta-analyses with the development of Alzheimer disease.
Neurophysiological effects of various music genres on electroencephalographic (EEG) cerebral cortex activity
Authors: Rodriguez Abraham Hafiz , Zallek Sarah Nath , Xu Michael , Aldag Jean , Russell-Chapin Lori , Mattei Tobias A. , Litofsky N. Scott
Published: November 2019

Background

Music has been associated with therapeutic properties for thousands of years across a vast number of diverse regions and cultures. This study expands upon our current understanding of music’s influence on human neurophysiology by investigating the effects of various music genres on cerebral cortex activity using electroencephalography (EEG).

Methods

A randomized, controlled study design was used. EEG data were recorded from 23 healthy adults, ages 19–28, while listening to a music sequence consisting of five randomized songs and two controls. The five studied music genres include: Classical, Tribal Downtempo, Psychedelic Trance (Psytrance), Goa Trance, and Subject Choice.

Results

Controls were associated with lower percentages of beta frequencies and higher percentages of alpha frequencies than the music genres. Psytrance was associated with higher percentages of theta and delta frequencies than the other music genres and controls. The lowest percentages of beta frequencies and highest percentages of alpha frequencies occurred in the occipital and parietal regions. The highest percentages of theta and delta frequencies occurred in the frontal and temporal regions. Subjects with prior music training exhibited increased percentages of delta frequencies in the frontal region. Subject gender and music preference did not have a significant influence on frequency band percentages.

Conclusions

Findings from this study support those of previous music therapy studies and provide novel insights regarding music’s influence on human neurophysiology. These findings also support the hypothesis that music may promote changes in cerebral cortex activity that have similarities to non-rapid eye movement (NREM) sleep, while the listener remains awake.
AKUMULASI LOGAM BERAT Pb, Cd, Ni DAN Zn PADA DAGING IKAN DI TELUK KAO, HALMAHERA
Authors: Edward Edward
Published: November 2019

Ikan merupakan sumber  protein, mineral, vitamin dan asam lemak omega-3-tidak jenuh (poly unsaturated), yang dianggap bermanfaat bagi kesehatan. Tujuan penelitian in  adalah untuk mengetahui  tingkat akumulasi logam berat timbal (Pb), cadmium (Cd), seng (Zn) dan nikel (Ni) pada beberapa jenis ikan yang berbeda di Teluk Kao, Halmahera. Penelitian ini dilakuan pada bulan November 2015. Contoh ikan  yang dianalisis adalah ikan suo (Sphyraena jello),  tatameri (Gazza minuta), gaca  (Lutjanus argentimaculatus), totodi  (Synodus foetens)    bubara (Caranx sp), ngafi  (Stolephorus indicus) dan biji nangka (Upeneus vittatus). Kadar Pb, Cd, Zn dan Ni ditentukan dengan alat Spektrofotometer Serapan Atom (AAS). Hasilnya menunjukkan kadar  Pb, Cd, Zn dan Ni masih sesuai dengan nilai ambang batas aman yang ditetapkan oleh Standard Nasional Indonesia (SNI) 2009. Untuk mengoptimalkan perlindungan terhadap kesehatan manusia, perlu dilakukan pemantauan kadar Pb, Cd, Zn dan Ni dalam daging ikan yang hidup di Teluk Kao, mengingat Teluk Kao merupakan satu-satunya perairan yang menerima masukan limbah yang berasal dari kegiatan masyarakat dan penambangan emas. Strategi manajemen risiko harus fokus pada pengurangan paparan potensial yang berasal dari konsumsi ikan.
Work-family culture, work-family balance and perceived performance
Authors: Jiménez-Figueroa Andrés Eduardo , León-Gonzalez Barbara , Poblete-Gajardo Melissa
Published: November 2019

El presente estudio analiza la relación entre Cultura trabajo-familia, Equilibrio trabajo-familia y desempeño percibido de los trabajadores de una empresa de retail de la Región Metropolitana, basados en el Modelo de Organizaciones Saludables y Resilientes. Se realizó un análisis cuantitativo a 162 trabajadores, a los cuales se les aplicó, el Cuestionario de Interacción Trabajo-Familia (SWING), el Cuestionario de Cultura trabajo-familia y la Escala de Desempeño In rol y Extra rol. Se observa una relación positiva y significativa entre la cultura y el equilibrio trabajo-familia (p < 0.01; r = .53), entre cultura trabajo-familia y desempeño percibido (p < 0.01; r = .24) y entre equilibrio trabajo-familia y desempeño percibido (p < 0.01; r = .21) de los trabajadores. Se concluye la existencia de una relación significativa de interdependencia positiva entre las variables, sin embargo, es baja para la variable Desempeño Percibido, por lo tanto, para estudios posteriores, se sugiere ampliar la muestra y orientar esta variable tanto a factores organizacionales como sociodemográficos.
Family businesses, risk and adverse selection in the agency relationship
Authors: Tuirán-Álvarez Kevin Yesid , Sanabria-Landazábal Nestor Juan , Acosta-Prado Julio Cesar
Published: November 2019

The objective of this article is to review the literature on family businesses in relation to risk and adverse selection. Outstanding aspects such as the relationship with finances, socio-emotional wealth, incentives, problems of management and business performance, agency costs, diversification, succession, risk, institutionality and agency costs were found. In many cases the results are inconclusive and contradictory. However, it was possible to identify that organizational cultures can be explained from changing environments. This generates new risks and uncertainties in the organization. The relevance of the speed of information exchange in the market as a source of risk and adverse selection was also identified.RESUMENEl objetivo de este artículo es hacer una revisión de la literatura sobre las empresas de familia en relación con el riesgo y la selección adversa. Se encontraron aspectos destacados como la relación con las finanzas, la riqueza socioemocional, los incentivos, los problemas de la gestión y el desempeño empresarial, los costos de agencia, la diversificación, la sucesión, el riesgo, la institucionalidad y los costos de agencia. En muchos casos los resultados no son concluyentes y son contradictorios. Sin embargo, se logró identificar que las culturas organizacionales se pueden explicar a partir de los entornos cambiantes. Esto genera nuevos riesgos e incertidumbres en la organización. También se identificó la relevancia de la velocidad de intercambio de información en el mercado como fuente de riesgo y selección adversa.RESUMOO objetivo deste artigo é revisar a literatura sobre empresas de familia em relação ao risco e seleção adversa. Encontramos aspectos marcantes como a relação com finanças, riqueza socioemocional, incentivos, problemas de gestão e desempenho empresarial, custos de agência, diversificação, sucessão, risco, institucionalidade e custos de agência. Em muitos casos, os resultados são inconclusivos e contraditórios. No entanto, foi possível identificar que as culturas organizacionais podem ser explicadas a partir de ambientes em mudança. Isso gera novos riscos e incertezas na organização. A relevância da velocidade de troca de informações no mercado como fonte de risco e seleção adversa também foi identificada.
Optimization model for the installation of SAMU bases: application in Natal-RN
Authors: Dos Santos Cabral Eric Lucas , Silva Castro Wilkson Ricardo , Cavalheiro Francisco Claudia Aparecida , Pires de Souza Ricardo
Published: November 2019

A Medical Emergency Service is responsible for providing pre-hospital acute care and has the key role of providing good services to people, especially in urban areas. In Brazil, the Emergency Medical Assistance Service (SAMU) operates in several cities and aims to reach the victim early after an injury to his health has occurred, by sending vehicles manned by trained personnel. The objective of this study was the application of a mathematical model aiming to designate neighborhoods for the installation of new SAMU bases that minimize the distance traveled by the ambulances in the city of Natal / RN. After data collection, it was found that the average service response time of the SAMU was over 40 minutes for calls classified as red code. The average number of calls in 2015 was 1,930 per month, in this city with a population of 800,000. The application of the model allowed for the simulation of scenarios with the installation of 3 to 8 fixed bases. There was a significant reduction in the distance traveled by the ambulances which reached 48%, after the installation of eight bases. In other words, there was a reduction of 6,560 kilometers traveled per month by ambulances. The new SAMU bases are being installed in containers to minimize installation costs and easy relocation in the near future.
Avaliação Ergonômica por meio da Eletromiografia de Superfície: Estudo de Caso na Indústria Automotiva
Authors: Merino Eugenio Andrés Díaz , Silva Lincoln , Cunha Julia Marina , Da Silva Ilandir Ferreira , Merino Giselle Schmidt Alves Díaz
Published: November 2019

A indústria automotiva é um importante setor da economia brasileira, sendo responsável por 5% do PIB do país. Apesar dos avanços tecnológicos da indústria, algumas das atividades realizadas ainda dependem de trabalho manual, repercutindo em riscos à saúde do trabalhador. Nesse sentido, a ergonomia atua visando melhorias de segurança e consequente aumento da produtividade no setor. Assim, esta pesquisa teve como objetivo avaliar, por meio da eletromiografia de superfície, os riscos de lesões musculoesqueléticas inerentes à atividade de montagem de veículos desempenhada por um operador de linha de montagem em uma montadora de automóveis da região sul do Brasil. Como resultado, identificaram-se duas principais posturas de trabalho, em pé e sentado, sendo que em ambas posições o trabalhador realiza a colocação manual de peças adotando flexão de tronco e anteriorização da cabeça. Observou-se maior ativação mioelétrica na postura em pé, principalmente nos grupos musculares multífido esquerdo e trapézio superior direito. Apesar disso, ocorre um favorecimento da recuperação muscular na posição em pé, ainda que ambas as posições apresentem tendência de fadiga muscular e possam levar o trabalhador a sofrer desordens musculoesqueléticas.
Characterisation studies on the particle size effect of calcium carbonate in high-strength concrete
Authors: Maheswaran Srinivasan , Ramachandra Murthy Avadhanam , Ramesh Kumar Vedachalam , Karunanithi Arthi
Published: November 2019

The main objective of this study was to determine the hydration activity and shrinkage of high-strength concrete (HSC) after the incorporation of different particle sizes of calcium carbonate (CaCO3). Three different sources of calcium carbonate – lime sludge (a residue collected from the paper and pulp industry, size ∼43 μm), commercial micro-calcium carbonate (size ∼13 μm) and commercial nano-calcium carbonate (size <100 nm) – were used as partial replacements of cement in HSC. Particle size analysis, heat of hydration, compressive strength and shrinkage aspects for various mixes were studied. The results showed an enhancement of the hydration reaction due to the nucleation effects of calcium carbonate and a considerable improvement in the reduction of shrinkage volume, hence the minimisation of shrinkage cracks. It was also found that shrinkage was significantly reduced with the incorporation of nano-sized particles rather than micro-sized particles. Compared with the control mix, all the mixes with different sizes of calcium carbonate showed a significant increase in compressive strength. To substantiate the obtained results, qualitative and quantitative analyses (X-ray diffraction, thermogravimetric analysis and differential thermogravimetric analysis, Fourier transform infrared spectroscopy and scanning electron microscopy) were carried out to determine the hydration behaviour of cementitious pastes incorporating calcium carbonate without aggregates.
L’humour noir et ses alliés dans l’œuvre de Piedad Bonnett
Authors: González-Valderrama Jonnathan Leonardo
Published: November 2019

Sujet : Le propos de cet article, c’est de montrer au lecteur que l’humour est un outil critique s’il est mis en scène avec une précision mordante en employant une taxonomie diverse en ce qui concerne à ce sujet; c’est ainsi que le sarcasme, l’humour noir, la caricature et l’ironie deviennent une source d’approche intellectuel à la non-conformité, mais aussi à la beauté des personnages et des voix poétiques de Bonnett afin de faire face au monde fictionnel, lequel est toujours un petit miroir d’une partie de la société Colombienne. Méthodologie : Ce travail est qualitatif et il s’agit d’exécuter un contraste entre les passages des romans et recueils de poèmes avec la théorie et la critique des auteurs qui aient déjà « transité » par les pages de l’écrivain. Cet article est le résultat d’un travail de recherche pour le Master 2 Etudes Hispaniques et Hispano Américaines (Parcours Recherche), au sein de l’Université Sorbonne Nouvelle Paris iii (France) durant la période 2014-2015. Conclusions : L’humour chez Bonnett possède une double facette : comme positionnement philosophique face à ce que les personnages ou les voix poétiques critiquent (chez eux ou chez les autres) ou comme récompense et commémoration.
Governing Trade-Offs and Building Coherence in Policy-Making for the 2030 Agenda
Authors: Nilsson Måns , Weitz Nina
Published: November 2019

This article introduces a suggested comprehensive framework for identifying, assessing and governing trade-offs and enhancing coherence in public policy decision-making. The framework is based on a simple three-stage model of policy-making: understanding policy interactions (input), integrating policy-making (process), and assessing ex ante policy decisions (output). The first stage is tackled with an interactions assessment framework, identifying how different sectors or ministries relate to each other in terms of their respective objectives, and on what topics negotiations are required to manage trade-offs. The second stage draws on approaches and experiences in environmental policy integration. It focuses on institutional procedures, structures and rules that enable integrated policy-making processes. The third stage draws on the longer-standing policy-analytical field of impact assessment applied to sustainable development. The article discusses the conceptual and theoretical foundations of each stage, as well as practical policy experiences. Discussing this in the context of 2030 Agenda implementation, the article suggests how trade-offs and policy coherence can be better governed using adapted policy-analytic methods and approaches.
The Theory of Democratic Antinomies and the Identification of Value Trade-Offs in Political Practice
Authors: Hidalgo Oliver
Published: November 2019

In theory, the idea of democracy consists of several insoluble contradictions, aporias, and conflicts. In practice, democracy demands an effective balancing of its essentially opposing principles and values in order to preserve an authentic character as well as to avoid its inherent self-destructive tendencies. In this regard, the concept of value trade-offs promises a heuristic tool to grasp both the analytical and normative impact of a political theory which takes the complexity of democracy seriously. Proceeding from this, the contribution will demonstrate to what extent the conceptualisation of democratic antinomies and the notion of value trade-offs can be seen as a kind of communicating vessel. The article’s general argument is that democracy is defined by several antinomies that are irreducible in theory and therefore require trade-offs in political practice. Moreover, it will discuss three relevant issue areas to suggest the approach’s empirical relevance and to prove the existence of value trade-offs as an operating benchmark for the legitimacy and consolidation of democratic processes on the one hand but also for their shortcomings and risks on the other. Correspondingly, the article concerns the antinomic relationships between freedom and security, economic growth and sustainability, and finally, democracy and populism to underpin the general perception that the success of democratic institutions first and foremost depends on the balance of the necessarily conflicting principles of democracy.
Aplication of Image Processing to Determine The Freshness of Tilapia Fish (Oreochromis niloticus)
Authors: Kalista Ayu , Redjo Amin , Rosidah Umi
Published: November 2019

The quality of fresh fish will decrease immediately after death. One of the indicators of fish quality is the changes of the gills color. The aim of this research was to determine the changes of red color in the gills of tilapia using image processing as an indicator of fish freshness. The research method used is the Explanatory Research where the independent variable (x) is tilapia which stored at room temperature for 12 hours. The dependent variable (y) was the intensity value of red. The quality of fish could be grouped into several categories, such as high quality, good quality, limit of acceptability and spoilt. The Observation was carried out with a time of 0 hours to 12 hours (4 hour interval). The results showed that storage time affected the deterioration of fresh quality. The high quality category has a red percentage value of 82.18%. Fresh category has a red percentage value of 67.10%. The limit of acceptability category has a value of 38.52% and the spoiltcategory has a red percentage value of 9.92%.
Matematik Öğretmeni Adaylarının Kullandıkları Soruların İncelenmesi: Öğretmenlik Uygulaması Dersinden Yansımalar
Authors: CUMHUR Fatma , GÜVEN Bülent
Published: November 2019

Bu çalışmada matematik öğretmeni adaylarının,
Öğretmenlik Uygulaması dersi kapsamında yürüttükleri derslerinde kullandıkları
soruların “ön bilgileri kontrol etme, odaklama, kavram yanılgılarını belirleme,
yönlendirme, sorgulama ve değerlendirme” amaçları doğrultusunda incelenmesi
amaçlanmıştır. Çalışmaya bir devlet üniversitesinin Ortaöğretim Matematik
Öğretmenliği programına devam eden altı 5.sınıf öğretmen adayı katılmıştır.
Çalışmada her bir öğretmen adayının Öğretmenlik Uygulaması derslerinde
yürüttükleri ikişer ders saati gözlemlenmiş ve kullandıkları sorular
tümdengelimsel içerik analizine tabii tutulmuştur. Elde edilen bulgulara göre,
öğretmen adayları ön bilgileri kontrol etme boyutunda sorulara daha fazla yer
verirken sorgulama ve kavram yanılgılarını belirleme boyutlarında ise çok az
soruya yer vermişlerdir. Öğretmen adayları bir de öğrencilerle diyaloglarını
kısa tutma ve öğrencilerin düşüncelerini derinleştirememe anlamında bazı
soruları niteliksel açıdan yetersiz kullanmışlardır. Elde edilen sonuçlardan
hareketle öğretmen adaylarının kullandıkları soruların işlevini fark ettirecek
ve bu soruların derinliğini artırmalarını sağlayacak uygulamaların öğretmen
yetiştirme programlarına entegre edilmesi önerilmiştir.
Beden Eğitimi Öğretmeni Adaylarının Serbest Zaman Sıkılma Algısı, Yaşam Doyumu ve Sosyal Bağlılık Düzeylerinin İncelenmesi
Authors: KARA Feyza Meryem , GÜRBÜZ Bülent , KÜÇÜK KILIÇ Sonnur , ÖNCÜ Erman
Published: November 2019

Bu araştırmanın amacı; beden eğitimi öğretmeni
adaylarının serbest zaman sıkılma algısı, yaşam doyumu ve sosyal bağlılık
düzeylerini bazı değişkenlere göre incelemek ve aralarındaki ilişkiyi
belirlemektir. Araştırmada veri toplama aracı olarak, “Serbest Zamanlarda
Sıkılma Algısı Ölçeği”, “Yaşam Doyumu Ölçeği ve “Sosyal Bağlılık Ölçeği" kullanılmıştır.
Katılımcıların serbest zamanlarında sıkılma ve doyumsuzluk algıları, yaşam
doyumları ve sosyal bağlılıkları cinsiyet değişkenine göre anlamlı bir şekilde
farklılaşmamaktadır. Öğretmen adaylarının serbest zamanlarında sıkılma ve
doyumsuzluk algıları ile yaşam doyumları sınıf ve düzenli olarak fiziksel
aktiviteye katılma durumu değişkenlerine göre anlamlı bir şekilde
farklılaşmazken, sosyal bağlılıkları ise sınıf ve düzenli olarak fiziksel
aktiviteye katılma durumu değişkenlerine göre anlamlı bir şekilde
farklılaşmaktadır. Diğer yandan öğretmen adaylarının serbest zamanlarında
sıkılma ve doyumsuzluk algıları ile sosyal bağlılıkları ekonomik durum
değişkenine göre anlamlı bir şekilde farklılaşmazken yaşam doyumları ise
ekonomik durum değişkenine göre anlamlı bir şekilde farklılaşmaktadır.
Ortaokul Öğrencilerinin Bilimsel Sorgulama Becerileri Algılarının, Merak, Motivasyon ve Tutum Açısından İncelenmesi
Authors: SARAÇOĞLU Mehtap , KAHYAOĞLU Mustafa
Published: November 2019

Bu çalışmanın amacı, ortaokul öğrencilerinin
bilimsel sorgulama becerileri algılarını Fen’e merak, motivasyon ve tutum
açısından incelemektir. Bu çerçevede araştırma ilişkisel tarama modeline göre
tasarlanmıştır. Araştırmanın katılımcılarını 2017-2018 eğitim ve öğretim
yılında Siirt il merkezde öğrenim gören 186 ortaokul öğrenci oluşturmuştur.
Araştırmada veri toplama aracı olarak “Fen’e Yönelik Bilimsel Sorgulama Becerileri Algı
Ölçeği”, “Fen’e Karşı Merak
Ölçeği”, “Fen Öğrenmeye Yönelik
Motivasyon Ölçeği” ve “Fen ve Teknoloji Dersi Tutum Ölçeği”
kullanılmıştır. Veriler korelasyon ve çoklu regresyon analizi teknikleri
kullanılarak çözümlenmiştir. Araştırma bulguları Fen’e karşı merak, motivasyon
ve tutumun ortaokul öğrencilerinin bilimsel sorgulama becerileri algılarının
önemli yordayıcıları olduğunu göstermektedir. Elde edilen sonuçlar fen eğitimi
ile ilgili alanyazın dikkate alınarak tartışılmıştır.
Matematiksel Düşünmenin Varsayımda Bulunma Bileşenine Yönelik Olarak Ortaokul Öğrencilerinin Kullandıkları Problem Çözme Stratejilerinin İncelenmesi
Authors: KÜKEY Ebru , ASLANER Recep , TUTAK Tayfun
Published: November 2019

Bu çalışma, ortaokul öğrencilerinin matematiksel düşünmenin varsayımda bulunma bileşeni kapsamında kullanmış oldukları problem çözme stratejilerini incelemek amacıyla yapılmıştır. Araştırma nitel araştırma yöntemlerinden durum çalışması olarak tasarlanmıştır. Çalışma, 96 ortaokul öğrencisi ile yürütülmüştür. Araştırmada veriler, matematiksel düşünmenin varsayımda bulunma bileşenine yönelik olarak hazırlanan rutin olmayan problem ile elde edilmiş ve elde edilen verilerin analizi aşamasında içerik analizi kullanılmıştır. Öğrencilerin problemi çözerken kullanmış oldukları stratejiler incelendiğinde, denklem kurma ile tahmin ve kontrol stratejilerini kullandıkları belirlenmiştir. Bu doğrultuda öğrencilerin problem çözme stratejilerinden iki tanesini kullandıkları görülmüştür. Bu nedenle diğer problem çözme stratejileri de kullanabilmeleri için öğretim sürecinde bu noktaya dikkat edilmesi gerektiği düşünülmektedir.