bluuebunny/crossref_metadata_2025 huggingface dataset:
A PROSPECTIVE STUDY TO EVALUATE THE ROLE OF INTRAVENOUS TRANEXEMIC ACID IN REDUCING THE BLOOD LOSS DURING TOTAL KNEE ARTHROPLASTY
Authors: BAKSHI AMANDEEP SINGH , MEHTA HARRY , RAINA SUKHIL , SAHNI GIRISH , GERA KARAN
Published: September 2024

Objective: The goal of this research was to determine how well intravenous tranexamic acid works in minimizing excessive bleeding after total knee arthroplasty.
Methods: The study was done on 50 patients of different age groups. Patients were randomly separated into two groups of 25 each. Group 1 were those who received intravenous tranexamic acid and group 2 were those who did not receive intravenous tranexamic acid. SPSS software was used to keep track of everything that happened and assess the outcomes.
Results: Patients in Group A had a mean perioperative blood loss of 298.04 ml, whereas those in Group B lost 447.2 ml on average after surgery. When comparing the two groups statistically, it was shown that group A had considerably larger mean perioperative blood loss than group B.
Conclusion: Patients in group B had substantially lower mean hemoglobin than patients in group A at the postoperative day 1 and postoperative day 7 measurements.
TO EVALUATE THE ANTIUROLITHIATIC ACTIVITY OF AQUEOUS EXTRACT OF CATHARANTHUS ROSEUS IN ETHYLENE-GLYCOL-INDUCED UROLITHIASIS IN RATS
Authors: MALHOTRA MEENAKSHI , SINGH AJEET PAL
Published: September 2024

Objective: This study aimed to evaluate the potential antiurolithiatic activity of the aqueous extract of *Catharanthus roseus* in a rat model of ethylene-glycol-induced urolithiasis.
Methods: Thirty male Wistar rats were divided into five groups: Group I served as the control, Group II received ethylene glycol (0.75% v/v) in drinking water for the induction of urolithiasis, Group III received standard treatment (cystone), and Group IV was treated with the aqueous extract of Catharanthus roseus (200 mg/kg). Throughout the experimental period, various parameters such as urinary calcium, phosphate, oxalate levels, and kidney histopathology were assessed to evaluate the antiurolithiatic potential of Catharanthus roseus.
Results: The results demonstrated a significant reduction in urinary calculi formation, lowered calcium and oxalate excretion, and ameliorated histological changes in the kidneys of rats treated with the aqueous extract of Catharanthus roseus.
Conclusion: Our findings suggest that the aqueous extract of *Catharanthus roseus* possesses promising antiurolithiatic activity, potentially attributed to its ability to modulate urinary stone-forming parameters. Further studies are warranted to elucidate the underlying mechanisms and explore the therapeutic potential of *Catharanthus roseus* in managing urolithiasis.
SIMULTANEOUS ESTIMATION OF LORATADINE AND AMBROXOL HYDROCHLORIDE IN BULK AND PHARMACEUTICAL FORMULATIONS BY SIMPLE UV SPECTROPHOTOMETRY
Authors: KAMBLE ABHISHEK , TAMBOLI ASHPAK , ZADE AJINKYA , PATIL KIRAN
Published: September 2024

Objective: The simple, rapid, accurate, precise and cost-effective UV spectrophotometric methods have been developed and validated for simultaneous estimation of Loratadine and Ambroxol Hydrochloride in tablet dosage form.
Methods: The UV methods have been developed utilizing concept of standard addition utilizing Methanol: Water (50:50%, v/v) as a solvent. Method is estimation using simultaneous equation method at 305 nm (λmax of Loratadine) and 242 nm (λmax of Ambroxol Hydrochloride).
Results: Linearity was observed in range of 5-25 μg/ml each for Loratadine and Ambroxol Hydrochloride, respectively for methods. The correlation coefficient (r2) value was found to be values in the range of 0.9941-0.9961. The assay result of marketed formulation was found to be 99.98 % and 100.07 % of Loratadine and Ambroxol Hydrochloride.
Conclusion: The present result shows that the proposed method can be successfully implemented for estimation of Loratadine and Ambroxol Hydrochloride in bulk and its marketed formulations. Methods were statistically validated as per ICH guidelines and can be successively applied for analysis for tablets formulation.
SEROPREVALENCE OF HUMAN BRUCELLOSIS AMONG THE HIGH-RISK POPULATION
Authors: LAVANYA K. , SUBHASHINI B. SRI VANI VIJAYA , KAMALA P.
Published: September 2024

Objective: Brucellosis is a zoonotic disease of worldwide distribution and has great economic concern. It is a contagious disease of ruminant animals but also effects human beings. The duration of the disease can vary from a few weeks to many months.
Methods: A total number of 200 samples tested for RBPT and STAT by using phenol saline as diluent to know the IgG titre and 2-mercaptoethanol was used as diluents to know the IgM titre. ELISA test performed for all positive samples in RBPT, to know the presence of IgM antibody. All the results were analyzed statistically.
Results: Of the 200 serum samples, highest proportion of positive cases were slaughter house worker 21.05% distribution according to positivity of RBPT and STST highest proportion in slaughter house workers 13.5% and lowest proportion in PUO cases 6.97%.
Conclusion: Prevention of human brucellosis focuses mainly on elimination of infection among farm animals. Cooperation is recommended between public health and veterinary officials to overcome the failure of controlling disease among both animals and humans.
On equienergetic graphs and graph energy of some standard graphs with self loops
Authors: Popat Kalpesh M. , Shigala K. R.
Published: September 2024

Let GS be the graph of order n and containing σ self-loops. The energy E(GS) of graph GS is defined as E(GS)= Σni=1|λi- σ/n|,where λ1, λ2,…, λn, be the eigenvalues of the adjacency matrix of GS. Two non-isomorphic graphs G1 and G2 of the same order are said to be equienergetic if they have same energy. The proposed research is an effort to expand the concept of equienergetic graphs from simple graphs to graphs having self-loops. In the present work, we have obtained a pair of equienergetic graphs and the energy of complete graphs as well as complete bipartite graphs with self loops.
Digital Project Management and Budgeting System
Authors: Bai Dr. M. Kalpana Devi
Published: September 2024

This paper presents a platform that facilitates budgeting and project management. Every organization needs project management since it determines how tasks are assigned and how well they are accomplished within the allotted period. The significance of project scope and techniques to reduce budget overruns are highlighted in this abstract. A key component of project management is project budgeting, which accounts for budgeted, actual, and spent funds. The budget rises in the event that there is a longer delay than the anticipated completion date. Consequently, we require administration in order to monitor the project's advancement. The project involves the design and implementation of a web application tailored for project management purposes. With Accurate project management we can control the budget within the estimation otherwise the budget will be exceeded and the company will face loss. The project is developed as a Sass model which many clients can use this product on pay and use basis. This project provides a solution for project management by using AngularJS as frontend framework, Java Springboot as a backend framework and MongoDB as a database. In this paper we are going to discuss about the frontend part and its implementation.
Predictive Modellig of Dementia Using Machine Learning
Authors: Wani Ab Rashid , Sodhi Dr. Gurinder Kaur
Published: September 2024

Abstract: In an era marked by relentless technological advancement and a burgeoning aging population, dementia has appeared as a significant societal challenge. The relentless cognitive decline it brings not only takes a toll on individuals and their families but also poses a formidable challenge to healthcare systems worldwide. Previous research in this domain has encountered significant challenges in accurately predicting and mitigating dementia's progression. This proposed work seeks to address these challenges by leveraging cutting-edge machine learning methodologies, presenting a clear path towards more effective prediction and potential mitigation of dementia. Our research constitutes a pioneering investigation into the use of cutting-edge machine learning methods in the intricate field of medicine data sources, including neuroimaging, genetics, and clinical records. Previous researchers have grappled with the complex character of these data sources, struggling to unveil mild designs and insights that often remain concealed from the naked eye. Our approach aims to overcome these challenges by utilizing a well-defined machine learning algorithm, specifically a deep neural network, with carefully selected hyperparameters. The deep neural network is chosen for its ability to handle complex, high-dimensional data and uncover hidden patterns. Through the scrupulous curation and rigorous analysis of extensive datasets, our proposed work represents a significant step forward within the domain of studies on dementia. Our goal is to identify even the smallest changes in the form and function of the brain and to provide insight into the intricate genetic factors contributing to this enigmatic condition. Our algorithm's parameters are carefully tuned to ensure optimal performance, with an emphasis on sensitivity and specificity, crucial in dementia diagnosis and prediction.
Effectiveness of Some Natural Enemies in Limiting the Spread of Fall Armyworm, Spodoptera frugiperda
Authors:   Plant Protection Department, Faculty of Agriculture, Damascus University, Syria, Basheer Abdulnabi M. , Mohammed Eyad M. ,   General Directorate of Plant Protection - Damascus, Syria;, Soliman Shady M. ,   Biological Control Department, Hama, Syria, Naoof Mais A. ,   Biological Control Department, Hama, Syria
Published: September 2024

Basheer, A.M., E.M. Mohammed, S.M. Soliman and M.A. Naoof. 2024. Effectiveness of Some Natural Enemies in Limiting the Spread of Fall Armyworm, Spodoptera frugiperda. Arab Journal of Plant Protection, 42(3): 349-354. https://doi.org/10.22268/AJPP-001251 The field work of this study was carried out in corn fields in Hama governorate and the laboratory work was carried out in Hama Center for Rearing Natural Enemies (HCRNE). This study aimed to evaluate the effectiveness of the egg parasitoid Trichogramma principium and larval parasitoid Bracon hebetor in the control of fall armyworm (FAW), Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae). The rates of parasitism on FAW eggs ranged from 25 to 50%. It was found that there was an inverse relationship between the increase in the number of eggs per batch and the rate of parasitism. The study also showed that the parasitoid Bracoon hebetor parasitized the fourth, fifth, and sixth larva instars in varying proportions, and the parasitism rate ranged from 10 to 80%. Keywords: Corn, natural enemies, fall armyworm, Syria
Hyperspectral Imaging for Determining Reflection Variables in Chilli Leaves Infested with Green Peach Aphid
Authors:   Plant Protection Department, College of Agriculture, Al-Muthanna University, Iraq, Atshan Lafta .Awad , Ibrahim Hani .Ahmad ,   Horticulture Department, Technical College of Akre, Akre University for Applied Sciences, Kurdistan Region, Iraq, Al-Hussainawy Khalid Jaber ,   Plant Protection Department, College of Agriculture, Al-Muthanna University, Iraq, Atshan K.A. ,   Department of Biology, College of Education for Pure Science, University of Al-Muthanna, Iraq.
Published: September 2024

Atshan, L.A., H.A. Ibrahim, K.J. Abdulrazzaq and K.A. Atshan. 2024. Hyperspectral Imaging for Determining Reflection Variables in Chilli Leaves Infested with Green Peach Aphid. Arab Journal of Plant Protection, 42(3): 299-305. https://doi.org/10.22268/AJPP-001256 Aphid infestations cause a physiological response detectable by a remote leaf reflectance sensor. Changes in the spectral signature of specific wave bands, measured with hyperspectral imagery (HI), may also relate to the absence, presence and/or level of infestation of aphids. Aphids cause significant damage to crops and yields in the field as well as in greenhouses. Green peach aphid, Myzus persicae (Sulzer) destroy chloroplast cells; this damage can be spectrally detected in the reflectance of the visible and near-infrared (NIR) regions. The spectral curve showed that the aphid-infested chili leaves reflectance in the NIR, decreased in time with the increase of aphid population. Although the aphid’s activity occurred on the leaves underside, their damage can be spectrally detected by reflection data from the upper side. Early aphid damage was identified in limited areas of chili leaf and this damage showed to be the only harm inflicted on the plant, also proven by the HI data obtained. Surface reflectance (%) from un-infested chili was lower in the visible and higher in the NIR light 90A spectrum when compared with aphids-infested chili. The overall classification accuracies of 89% for damage detection were achieved. These results indicated that HI can be effectively used to accurately detect and quantify aphid infestation in chili for site-specific aphid management. It can be potentially applied for limited areas as well as fields as an early detection tool for aphid management. This study aimed to spectrally explore the ability to assess the level of aphids damage in a limited area grown with the chili crop. Keywords: Hyperspectral imagery, aphids, chilli pepper, near-infrared
Alzheimer Disease: Cognizance and Potential Aspect of Disease Pathophysiology & Recently Developed Therapeutic Drug Strategies
Authors: Journal Rakesh Kumar , Saini Manita , Bhattacharya Tilottama , Deepika Dr , Kumari Akancha
Published: September 2024

Alzheimer’s disease (AD) is a multifactorial neuron-degenerative old age disease which has no cure. AD causes degeneration of the neuronal cells in the brain which is the main reason of dementia, characterized by a decline in the thinking and independence in daily routine activities. In most of the cases, AD is suspected to be caused by a combination of genetic, lifestyle and environmental factors, affecting the brain over time. The currently approved therapy, which includes cholinesterase inhibitors, NMDA-receptor antagonists and their combinations provides only temporary symptomatic relief. Nowadays, the clinical research is targeting on understanding of Alzheimer pathology1. These are targeting the abnormal tau protein metabolism, removal of beta-amyloid, inflammatory response, cholinergic neuron and free radical damage treatments which can either that stop or modify the course of Alzheimer. Global efforts are continued to identify new targets to develop novel therapeutic agents for the treatment of AD.
Keywords: Alzheimer disease, Dementia, Drug therapy, Drug effect, Amyloid, Amyloid precursor protein, Tau proteins, Acetyl cholinesterase enzyme
FRENECTOMIA LABIAL SUPERIOR EM PACIENTE ODONTOPEDIÁTRICO: Relato de caso clínico em paciente de dez anos de idade da cidade de Mato Verde - MG
Authors: Sousa Idathoson Breno Dias de , Silva Maria Thais Rodrigues , Rocha Marcone de Oliveira , Teixeira Ítalo Lopes , Almeida Gabriela Lourenço Alves , Chagas Pablo Vinicyus Ferreira
Published: September 2024

Lip brakes have the function of limiting the movement of the lips, stabilizing the midline and inhibiting accentuated gingival exposure. The superior labial frenulum is a fold composed of mucous membrane and fibrous tissue. It is attached on one side to the inside of the upper lips and on the other side to the gums in the middle of the jaw. The objective of this study was to report a case of upper lip frenectomy in a pediatric dentistry patient. This is a study with a qualitative approach with a descriptive/observational objective. A survey was carried out in the municipality of Mato Verde-MG at Faculdade Verde Norte (FAVENORTE). A ten-year-old male patient was taken by the guardian to the dental clinic at Faculdade Verde Norte - FAVENORTE, with the following main complaint: “Large space in the front teeth”. After anamnesis, it was found that the patient had no systemic changes. On clinical examination, the presence of diastema between the permanent upper central incisors and a wide and voluminous upper labial frenulum was observed during the upper laboratory treatment. The treatment was surgical removal: Frenectomy using the Modified Archer Technique. In the case reported, it was demonstrated that the surgical technique was performed successfully, where the repositioning of the labial frenulum and new reinsertion were observed, promoting an improvement in the patient's quality of life.
Virtuālie asistenti: to veidi un darbības principi
Authors:   Matemātikas un informātikas institūts, Latvijas Universitāte, Grūzītis Normunds
Published: September 2024

The paper will discuss the types and principles of operation of virtual assistants in general. We will compare early rule-based solutions such as ELIZA and PARRY with modern solutions for specific tasks that include language models for automatic intent detection and named entity recognition, as well as response generation. Recent trends using deep learning approaches and generative language models will also be briefly discussed. The possibilities and challenges associated with the ‘memory’ and context understanding abilities of such models will be outlined, as well as the control capabilities of the models.
CATAÇÃO DE RESÍDUOS SÓLIDOS: UM ESTUDO SOBRE MULHERES CATADORAS
Authors: Paim Camardelo Ana Maria , Benedetti Alais , Cardoso Nostrane Kátia
Published: September 2024

Na catação de resíduos sólidos atravessam-se questões de gênero que estabelecem diferentes dinâmicas para o trabalho da mulher. Objetiva-se investigar as percepções das mulheres sobre sua inserção no trabalho da catação nas associações de reciclagem de Caxias do Sul/RS. Elaborou-se a análise de sete entrevistas realizadas com catadoras, por meio de análise de conteúdo. Estabeleceu-se três categorias: Precariedade do trabalho; Liderança e protagonismo; Percepção de ser catadora. Constatou-se que as catadoras são protagonistas de sua história e da construção da profissão. Esta análise não se esgota, merecendo futuras investigações as quais se destaca a interface entre trabalho e maternidade.
INTERSECCIONALIDADE, DESENVOLVIMENTO E TERRITÓRIO
Authors: Gomes Cilene , Paula Adriana Maria de , Toniolo Maria Angelica
Published: September 2024

Busca-se analisar as relações intersecionais de gênero e raça junto à questão do desenvolvimento e território. O desenvolvimento é influenciado por orientações filosóficas e ideológicas, e sua ligação com a equidade de gênero também perpassa diferentes perspectivas. Conceitos de interseccionalidade e consubstancialidade possibilitam analisar o desenvolvimento de segmentos da população feminina e a interdependência das relações sociais. Propõe-se análise estatística e do índice de equidade de gênero para as mesorregiões do estado paulista. A espacialização do índice possibilita aferir a importância de um olhar mais profundo sobre as relações de gênero e as múltiplas identidades aí envolvidas
A INVISIBILIDADE DOS CORPOS TRANS
Authors: Soares Silveira Miguel , Marione Schulz Rosangela
Published: September 2024

O presente estudo baseia-se na exploração do campo político brasileiro e na análise das candidaturas de pessoas trans no processo eleitoral municipal de 2020, entendendo de que forma ocorre esse fenômeno e observando dados constantes da base do TSE (Tribunal Superior Eleitoral). A partir das abordagens da consolidação do ativismo trans, da representação descritiva, bem como da análise da ocupação da arena eleitoral através do conceito de capital político, a pesquisa em epígrafe pretende dar maior visibilidade às investigações que versam sobre gênero e política, mais precisamente quanto às demandas de pessoas trans.
“We Read Pushkin Together, We Read it All”: Annenkov’s Edition of Pushkin’s Works in the Novel The Idiot
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kasatkina Tatiana A.
Published: September 2024

The article examines the significance and purposes of the presence in the novel The Idiot of the Annenkov edition of Pushkin’s collected works. Pushkin’s physical and material presence is described by the novelist in a persistent and emphasized manner. The article addresses Dostoevsky’s notion of the enduring presence of a departed individual in the structure of humanity if he or she has left behind a remarkable life story and/or significant books as the primary (obvious and basic) level of immortality. The concept of books as a new body for the deceased is considered. The alignment of Pushkin’s and Dostoevsky’s authorial theories of work as well as how the first, biographical volume of Pushkin’s works is woven into the fabric of the novel is examined. The meaning of prince Myshkin’s reproduction of Igumen Pafnuty’s “own handwriting” is discussed. Additionally, the article reveals several previously unrecognized allusions to Pushkin’s texts in the characters’ statements. The nature of the publication of Pushkin’s poem “The Poor Knight” in Annenkov’s edition is explained.
HMV_II
Authors: Catarina Braga
Published: September 2024

Fragments of an investigation carried out at the end of the 21st century get intermixed with the invisibility of the object of study — indoor air.
From a speculative practice between the scientific process, the artistic process and the affective, political, social and cultural process that we create with the things of the world, the appearance of a new body is proposed. It is inside a fictionalised laboratory that we get to see this collective, symbiotic and ancestral organism; a multispecies entity that transcends the borders between terrestrial bodies (mineral, human, vegetal, animal, technological) and time and space.
The exhibition and work being presented here is the result of the artist's residency with the LEPABE laboratory team of Environmental Sciences and Technologies (FEUP), which investigates and measures indoor air quality, studying its impact on human health.

This work is a result of project 2SMART, engineered Smart materials for Smart citizens, with reference NORTE-01-0145-FEDER-000054, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).
MONTSALVATGE AND HIS ATTEMPT TO ESCAPE FROM THE SPANISH CLICHÉ THROUGH THE ANTILLEANISM IN HIS CINCO CANCIONES NEGRAS
Authors: Ana Sanchez Donate
Published: September 2024

The Spanish cliché is an invention of the eighteenth and the nineteenth centuries. This exotic and romantic image of musical "Spanishness" had, and still has, an enormous influence on Spanish musicians and in the general approach to the interpretation of Spanish Music.
Through history the political powers have tried to make used of the stereotypes at their own convenience. Franco’s regime urged composers to adhere to a formalistic aesthetic, full of Spanish nationalistic clichés, in a clear attempt to unify and control a country rich in different cultures and folklore. Within this context, the question of musical nationalism inevitably arises as well as the way in which it was faced, surrounded, transformed and solved by the composers of the time.
Montsalvatge soon manifested a profound independence of criteria that took him away from falling into the Spanish cliché. He was the cultivator of a peculiar nationalism, at the same time far from Spanishism and Catalanism. Montsalvatge found in Antilleanism a sort of “secular post-nationalism", a personality of his own. The most famous example of this Antilleanism are his “Cinco Canciones Negras”
Free Speech Principles to Consider when Restricting Disinformation
Authors: Török Bernát
Published: September 2024

Disinformation is widely considered to be one of the most pressing issues confronting society in the new online communication environment of today. The present problem of disinformation, however, did not materialise in a vacuum, and so the response to it needs to be situated among established constitutional principles. This paper, based on the jurisprudence of the European Court of Human Rights and some relevant documents and recommendations in this area at the European level, summarizes the most representative European principles of freedom of speech that are highly relevant in forming a legal answer to the issue of disinformation. Clarification of the current constitutional doctrine suggests that measures to restrict communication in the fight against disinformation can only play a more significant role than at present if the basic principles of freedom of speech are set aside. We therefore argue that we should primarily seek other solutions.
Políticas y tratados para el fomento de la migración y establecimiento de migrantes en Barranquilla en el siglo XIX
Authors: D'Amato Castillo Guissepe , D'Amato Castillo Adriana Patricia
Published: September 2024

Este articulo estudia las actividades empresariales de migrantes que se vincularon a la vida productiva de Barranquilla en el siglo XIX. Como principal puerto de Colombia, Barranquilla se convirtió en un espacio de intercambio para el comercio, el capital y los extranjeros que veían en este sitio una “puerta” para el desarrollo económico de sus casas comercializadoras, bancos y fábricas. El objetivo principal es mostrar casos exitosos de empresarios norteamericanos, europeos e hispanoamericanos que encontraron en Barranquilla oportunidades para incrementar sus capitales, y cuya migración económica fue exitosa en la medida que se articularon a dinámicas propias de una ciudad caribeña; con unas estructuras culturales y sociales diferentes a la de sus países, y en donde aprendieron a sortear las adversidades propias de la época. El diseño metodológico hace una revisión histórica sobre los procesos migratorios en las ciudades - puertos del Caribe colombiano, puntualmente sobre Barranquilla debido a la expansión económica que vivió por las actividades de banqueros, comerciantes y empresarios migrantes. Dentro de los resultados parciales se encontró una amplia sensibilidad de la cuenca del Caribe por la recepción de migraciones transatlánticas en época contemporánea, especialmente para grupos con iniciativas comerciales y empresariales en los territorios con notable crecimiento económico.
Enhancing architectural image processing: A novel 2D to 3D algorithm using improved convolutional neural networks
Authors: Zou Qianying , Liu Fengyu , Liao Yuan
Published: September 2024

In light of the escalating advancements in architectural intelligence and information technology, the construction of smart cities increasingly necessitates a higher degree of precision in architectural measurements. Conventional approaches to architectural measurement, characterized by their low efficiency and protracted execution time, need to be revised to meet these burgeoning demands. To address this gap, we introduce a novel architectural image processing model that synergistically integrates Restricted Boltzmann Machines (RBMs) with Convolutional Neural Networks (CNNs) to facilitate the conversion of 2D architectural images into 3D. In the implementation phase of the model, an initial preprocessing of the architectural images is performed, followed by depth map conversion via bilateral filtering. Subsequently, minor voids in the images are rectified through a neighborhood interpolation algorithm. Finally, the preprocessed 2D images are input into the integrated model of RBMs and CNNs, realizing the 2D to 3D conversion. Experimental outcomes substantiate that this novel model attains a precision rate of 97%, and significantly outperforms comparative algorithms in terms of both runtime and efficiency. These results compellingly corroborate our model?s superiority in architectural image processing, enhancing measurement accuracy and drastically reducing execution time.
ALFormer: Attribute localization transformer in pedestrian attribute recognition
Authors: Liu Yuxin , Wang Mingzhe , Li Chao , Liu Shuoyan
Published: September 2024

Pedestrian attribute recognition is an important task for intelligent video surveillance. However, existing methods struggle to accurately localize discriminative regions for each attribute. We propose Attribute Localization Transformer (ALFormer), a novel framework to improve spatial localization through two key components. First, we introduce Mask Contrast Learning (MCL) to suppress regional feature relevance, forcing the model to focus on intrinsic spatial areas for each attribute. Second, we design an Attribute Spatial Memory (ASM) module to generate reliable attention maps that capture inherent locations for each attribute. Extensive experiments on two benchmark datasets demonstrate state-of-the-art performance of ALFormer. Ablation studies and visualizations verify the effectiveness of the proposed modules in improving attribute localization. Our work provides a simple yet effective approach to exploit spatial consistency for enhanced pedestrian attribute recognition.
Automatic conceptual database design based on heterogeneous source artifacts
Authors: Banjac Goran , Brdjanin Drazen , Banjac Danijela
Published: September 2024

The article presents an approach to the automatic derivation of conceptual database models from heterogeneous source artifacts. The approach is based on the integration of conceptual database models that are derived from source artifacts of one single type by already existing tools, whereby those models possess limited certainty given their limited completeness and correctness. The uncertainty of the automatically derived models from specific source artifacts is expressed and managed through the effectiveness measure of the generation of specific concepts of the input conceptual database models. The approach is implemented by the DBomnia tool ? the first online web-based tool enabling automatic derivation of conceptual database models from heterogeneous source artifacts (business process models and textual specifications). DBomnia employs other pre-existing tools to derive conceptual models from sources of the same type and then integrates those models. The case study-based evaluation proves that the implemented approach enables effective automatic derivation of the conceptual database model from a set of heterogeneous source artifacts. Moreover, the automatic derivation of the conceptual database model from a set of heterogeneous source artifacts is more effective than each independent automatic derivation of the conceptual database model from sources of one single type only.
Extracellular cleavage of microglia-derived progranulin promotes diet-induced obesity
Authors: Beom Park Chae , Hee Lee Chan , Won Cho Kae , Shin Sunghun , Hee Jang Won , Byeon Junyeong , Rim Oh Yu , Jun Kim Sung , Woo Park Jae , Myoung Kang Gil , Hee Min Se , Kim Seyun , Yu Rina , Kim Min-Seon
Published: September 2024

ABSTRACT

Hypothalamic innate immune responses to dietary fats underpin the pathogenesis of obesity, in which microglia play a critical role. Progranulin (PGRN) is an evolutionarily -conserved secretory protein containing seven-and-a-half granulin (GRN) motifs. It is cleaved into GRNs by multiple proteases. In the central nervous system, PGRN is highly expressed in microglia. To investigate the role of microglia-derived PGRN in metabolism regulation, we established a mouse model with a microglia-specific deletion of the Grn gene, that encodes PGRN. Mice with microglia-specific Grn depletion displayed diet-dependent metabolic phenotypes. Under normal diet-fed conditions, microglial Grn depletion produced adverse outcomes like fasting hyperglycemia and aberrant activation of hypothalamic microglia. However, when fed a high fat diet (HFD), these mice exhibited beneficial effects, including less obesity, glucose dysregulation, and hypothalamic inflammation. These differing phenotypes appear linked to increased extracellular cleavage of anti-inflammatory PGRN into proinflammatory GRNs in the hypothalamus during overnutrition. In support of this, inhibiting PGRN cleavage attenuated HFD-induced hypothalamic inflammation and obesity progression. Our results suggest that the extracellular cleavage of microglia-derived PGRN plays a significant role in promoting hypothalamic inflammation and obesity during periods of overnutrition. Therefore, therapies that inhibit PGRN cleavage may be beneficial for combating diet-induced obesity.

ARTICLE HIGHLIGHTS

• The mRNA expression of progranulin (PGRN), a precursor protein of granulins (GRNs), increases specifically in hypothalamic microglia during high-fat diet (HFD) feeding.

• Mice with microglia-specific depletion of the PGRN-encoding gene Grn, exhibit fasting hyperglycemia and aberrant activation of hypothalamic microglia under normal diet-fed conditions, whereas they resist the development of obesity, glucose dysregulation, and hypothalamic inflammation under HFD-fed conditions.

• The enhanced cleavage of anti-inflammatory PGRN into proinflammatory GRNs in the hypothalamus under HFD-fed conditions underlies the diet-dependent metabolic phenotypes of microglia Grn knockout mice.

• Inhibition of hypothalamic PGRN cleavage attenuates HFD-induced obesity and hypothalamic inflammation.
ATM kinase phosphorylates Ser15 of p53 in a pH-dependent manner
Authors: Pektaş Serap
Published: September 2024

The phosphorylation of Ser15 in the transactivation domain (TAD) of the tumor suppressor protein 53 (p53) by ataxia-telangiectasia mutated (ATM) kinase is a crucial step in the tumor suppressor function of p53. An understanding of the factors that affect the rate of Ser15 phosphorylation may provide new strategies for the manipulation of the ATM-p53 pathway in cancer therapy. In this study, the effect of electrostatic interactions between ATM and p53 was investigated by measuring the phosphorylation of Ser15 at varying pH ranges from 5 to 9. To achieve this, two different kinase assay methods were utilized: the ELISA technique, which directly quantifies the phosphorylated Ser15, and the Universal Kinase Assay, which assesses the formation of ADP. The results revealed that Ser15 phosphorylation was pH-dependent, with higher phosphorylation rates observed in the alkaline range. To ascertain whether the lower phosphorylation rates observed at acidic pH were due to protein denaturation, a pH-dependent solubility profile was generated using the CamSol server. The obtained results demonstrated comparable solubility rates within the pH range of the kinase assays performed. Furthermore, the significance of negatively charged residues in TAD1-39 was evaluated by substituting Asp and Glu residues with hydrophobic and uncharged hydrophilic residues in TAD1-39 using ChimeraX and subsequently comparing their interactions with the ATM using the protein-protein docking server HADDOCK2.4. The results of the docking simulations indicated that the alteration of negatively charged residues with uncharged ones resulted in a reduction in the efficiency of the interaction between the ATM and TAD1-39. In conclusion, it can be stated that electrostatic interactions between the ATM and TAD are important for optimal Ser15 phosphorylation.
Resumo: Que Intensidade e Duração para o Exercício do Jovem?
Authors:   Revista de Medicina Desportiva informa, Ribeiro Basil
Published: September 2024

As recomendações mais atuais da Organização Mundial de Saúde referem que as crianças e adolescentes devem realizar atividade física moderada-intensa durante 60 minutos por dia para melhorar a saúde física e mental. Contudo, em 2016, 81% dos adolescentes não cumpriam estes requisitos mínimos de atividade física, pelo que se tem agravada a aptidão física cardiorrespiratória. O Centers for Disease Control and Prevention (CDC) americano, através do programa National Youth Risk Behavior Survey, monitoriza os comportamentos saudáveis de adultos e de jovens (do 9º ao 12º ano, de instituições públicas e privadas). A pesquisa é realizada de dois em dois anos na primavera. A percentagem de pessoas que foram fisicamente ativas durante 60 minutos numa semana baixou de 28,7% em 2011 para 23,2% em 2019, ao passo que, no mesmo período, a percentagem relativamente ao uso de computador e de jogos de vídeo aumentou de 31,1%...
A Osteocondrose e a Traumatologia do Desporto
Authors:   Serviço de Medicina Física e Reabilitação ULS Coimbra, Pimentel Vivian , Páscoa Pinheiro João ,   Serviço de Medicina Física e Reabilitação ULS Coimbra; Faculdade de Medicina da Universidade de Coimbra
Published: September 2024

Osteochondrosis is defined as a failure in the endochondral ossification process. There is no consensus on the etiology, with multiple factors involved. The initial events in the pathogenesis remain uncertain, but evidence points to ischemic necrosis of the ossification center, located in the bone epiphysis. Each osteochondrosis has a homonymous clinical diagnosis assigned based on location. The most affected areas include the hip (Legg-Calvé-Perthes disease), knee (Osgood-Schlatter disease, Sinding-Larsen-Johansson disease), foot (Sever’s disease), elbow (Panner’s disease) and spine (Scheuermann’s disease). The most common clinical manifestations are mechanical pain and functional limitation during or after physical activity. Many injury prevention strategies involve educating young people, coaches, family members and monitoring symptoms. Early diagnosis and a structured approach allow, in most cases, clinical resolution and avoid long-term sequelae. Osteochondrosis was first described by König in 1887 and, despite more than a century of studies, there are still many challenging questions to elucidate to better understand this pathology.
Information Seeking Behavior Of The Clergy
Authors: Nweke Angela Chiwendu , Omosekejimi Ademola Ferdinand , Okoli Obioma Deborah
Published: September 2024

This study examines the information-seeking behavior of the clergy using parish pastors in the Redeemed Christian Church of God (RCCG) in Agbarho community in Delta State as a case study. The study seeks to identify the information needs, the sources of information, the purpose of the use of information, and the challenges to information seeking among RCCG parish pastors in Agbarho. A descriptive survey research design was adopted for the study. The total population for the study comprises 44 parish pastors of the RCCG in two Zones of RCCG Delta Province 4 in Agbarho Community. The entire population was used as a sample using the total enumeration sampling technique. The instrument used for data collection was a structured questionnaire. The data collected for this study were analyzed using simple percentage/frequency counts. The study found that RCCG pastors in Agbarho need and use the information for several issues such as sermon preparation, personal and church growth, church administration, evangelism, conflict resolution, meetings/programs, and personal/members’ welfare among others. They get the information they need from formal sources such as the Bible, books including all RCCG publications such as Open Heavens and Sunday school manuals, magazines (RCCG Bulletins), etc. Also, RCCG pastors in Agbarho community, Delta State, Nigeria also gets information from informal sources such as senior pastors, colleagues, friends in the ministry, church members, and family among others. In their effort to seek information, RCCG pastors in Agbarho community, Delta State, Nigeria faces some challenges such as limited financial resources, lack of access to ICT facilities, language barriers, information overload, time factor, and poor awareness of information sources. The study recommends that the RCCG authorities in conjunction with other churches and community leaders should establish and equip a library in every community where they are present as a way of advancing their Christian Social Responsibilities (CSR) as this will allow their pastors to have access to free and timely information among others.
Bibliometric Study and Visualization Analysis of Domestic and International Information Literacy Research in the Era of Artificial Intelligence
Authors: Wu Changhong , Zou Jiatong , Wang Shuyi , Sun Bo , Zhang Jingpeng
Published: September 2024

This study employs bibliometric and visualization analysis to investigate the landscape of information literacy research in the era of artificial intelligence (AI), comparing trends and characteristics across domestic and international contexts. Utilizing data from the Web of Science and CNKI databases, the analysis reveals a consistent upward trajectory in research output for both domains, with notable peaks reflecting technological advancements and policy initiatives. The research themes demonstrate a shift from early focuses on information retrieval and knowledge organization to more recent explorations of AI literacy, social media, and user engagement. International research highlights interdisciplinary collaboration, particularly between library science, computer science, and education. In contrast, domestic research emphasizes the integration of AI technologies within library automation, information service innovation, and smart library development. Author and institutional collaboration networks reveal a preference for university-based partnerships, with international collaborations extending across diverse disciplinary backgrounds. While both domains exhibit similar trends in collaboration patterns, the absence of certain high-publishing countries from international collaboration networks warrants further investigation. Research hotspots reflect the growing influence of AI on information literacy, with international research exploring fear appeals, social media, and deep learning, while domestic research focuses on deep learning applications, smart libraries, and bibliometrics.
GADGET MASA KINI: APAKAH MAHAL SELALU SAMA DENGAN BERKUALITAS ?
Authors: Kurniadi Hanif
Published: September 2024

People often decide based on prices that align with their budget or the desired quality. This study was undertaken to comprehend consumer perspectives on gadgets, with a specific focus on two primary aspects: the quality of the product and its price. This study employs a mixed-methods approach, gathering data through a questionnaire featuring alternative answer choices graded on a Likert scale. The scale has undergone extensive research and has been proven to meet both validity and reliability criteria. The questionnaire employed a simple random sampling technique, distributed to 75 students enrolled in the management study program at Sembilanbelas November Kolaka University. The analytical method applied in this research is perception analysis. This research found that consumer perceptions of gadgets are positively correlated with two main factors: product quality and price. This research recommends that gadget companies promote products that demonstrate a correlation between the price paid and the quality received. This approach is designed to boost their competitiveness and profitability in the highly competitive gadgets industry.
Keywords: consumer perception; price; product quality.
Orang sering membuat keputusan berdasarkan keseimbangan antara harga yang sesuai dengan anggaran yang sudah disiapkan atau kualitas yang diinginkan. Penelitian ini bertujuan untuk memahami pandangan konsumen terhadap gadget, dengan fokus khusus pada dua aspek utama: kualitas produk dan harga. Metode penelitian ini menggunakan pendekatan campuran, dengan pengumpulan data melalui kuesioner yang menyajikan pilihan jawaban alternatif yang dinilai menggunakan skala Likert. Skala ini telah melalui penelitian mendalam dan terbukti memenuhi kriteria validitas dan reliabilitas. Kuesioner diterapkan dengan teknik simple random sampling dan disebarkan kepada 75 mahasiswa program studi manajemen di Universitas Sembilanbelas November Kolaka. Metode analisis yang digunakan dalam penelitian ini adalah analisis persepsi. Hasil penelitian menunjukkan bahwa persepsi konsumen terhadap gadget memiliki korelasi positif dengan dua faktor utama: kualitas produk dan harga. Sebagai rekomendasi, penelitian ini menyarankan agar perusahaan gadget memasarkan produk yang menunjukkan hubungan seimbang antara harga yang dibayarkan dan kualitas yang diperoleh. Pendekatan ini dirancang untuk meningkatkan daya saing dan profitabilitas perusahaan di industri gadget yang sangat kompetitif.
Kata kunci : harga; kualitas produk; persepsi konsumen.
PENGARUH TRANSFORMATIONAL LEADERSHIP, KNOWLEDGE SHARING, DAN WORK ENGAGEMENT TERHADAP INNOVATIVE WORK BEHAVIOR PADA KARYAWAN JASA MARGA GROUP
Authors: Sofia Sarah , Aseanty Daesy
Published: September 2024

This study aims to analyze the role of transformational leadership, knowledge sharing, and work engagement on innovative work behavior in Jasa Marga Group Employees. The data in this study were collected from a sample of 320 (three hundred and twenty) employee respondents from the head office and branch offices. This type of research is quantitative research with cross-sectional data collection techniques, as well as purposive sampling techniques and data collection is done by distributing questionnaires and literature studies. The method model used in this research is simple regression analysis using SPSS version 27. The results showed that transformational leadership, knowledge sharing, and work engagement have a positive influence on innovative work behavior. The results of this study are expected to provide input for company management to motivate employees to increase the role of transformational leadership, knowledge sharing and work engagement in increasing the role of innovative work behavior and provide support in the form of appreciation for employees who have initiated innovation and provide loyalty for the benefit of achieving company goals.
Keywords: transformational leadership; knowledge sharing; work engagement; innovative work behavior.
Penelitian ini bertujuan untuk menganalisis peran Transformational Leadership, Knowledge Sharing, dan Work Engagement terhadap Innovative Work Behavior pada karyawan Jasa Marga Grup. Data pada penelitian ini dikumpulkan dari sampel berjumlah 320 (tiga ratus dua puluh) responden karyawan dari kantor pusat dan kantor cabang. Jenis penelitian ini adalah penelitian kuantitatif dengan teknik pengambilan data secara cross-sectional, serta teknik pengambilan sampel secara purposive sampling dan pengumpulan data dilakukan dengan melakukan penyebaraan kuesioner dan studi pustaka. Model metode yang digunakan dalam penelitian ini adalah analisis regresi sederhana dengan menggunakan SPSS versi 27. Hasil penelitian menunjukan bahwa transformational leadership, knowledge sharing dan work engagement memiliki pengaruh positif terhadap innovative work behavior. Hasil penelitian ini diharapkan dapat memberikan masukan bagi manajemen perusahaan untuk memotivasi karyawan dalam meningkatkan peran transformational leadership, knowledge sharing dan work engagement dalam meningkatkan peran innovative work behavior, serta memberikan dukungan berupa apresiasi terhadap karyawan yang telah menggagaskan inovasi, dan memberikan loyalitasnya untuk kepentingan dalam mencapai tujuan perusahaan.
Kata kunci : transformational leadership; knowledge sharing; work engagement; innovative work behavior.