bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of PROMIS CAT Administration in the Ambulatory Sports Medicine Clinic With Respect to Cost and Patient Compliance: A Single-Surgeon Experience
Authors: Lizzio Vincent A. , Blanchett Jacob , Borowsky Peter , Meldau Jason E. , Verma Nikhil N. , Muh Stephanie , Moutzouros Vasilios , Makhni Eric C.
Published: January 2019

Background:

Pay-for-performance reimbursement models are becoming increasingly popular, but the implementation of a routine patient-reported outcome (PRO) collection system places additional burden on both the patient and the provider. The Patient-Reported Outcomes Measurement Information System (PROMIS) was developed in an effort to make PRO collection more practical and efficient, but providers may be reluctant to embrace a transition to a PROMIS-based clinical outcome registry.

Hypothesis:

PROMIS can be successfully incorporated into daily clinical practice, with an overall patient compliance rate of 80%.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

As part of routine practice, all patients presenting to a single surgeon’s sports medicine clinic for an appointment were asked to complete a series of PROMIS computerized adaptive tests (CATs), including PROMIS Physical Function, Physical Function–Upper Extremity, Pain Interference, and Depression subscales. Overall compliance was calculated by dividing the number of survey sets completed by the number of eligible clinic visits. Compliance rates were further assessed by patient age, type of clinic visit, and location of injury. Costs associated with this system of routine PRO collection were categorized as start-up or maintenance costs.

Results:

From August 7, 2017, to December 8, 2017, there were 581 patients (1109 clinic encounters) who met inclusion criteria for the study. Of the 1109 clinic encounters, there was an overall compliance rate of 91.3% (1013/1109 visits during which the patient completed the entire PROMIS survey set). Overall, the full survey set consisted of a mean 15.3 questions and took a mean of 2.6 minutes to complete. Patients who were aged ≥62 years had a significantly lower compliance rate (81.8%; P < .0001) than each of the younger patient quartiles. When analyzing patients by the most common locations of injury (elbow, shoulder, hip, knee), the compliance rate for completing PROMIS was significantly higher for the hip than for the shoulder (95.1% vs 88.9%, respectively; P = .02). The cost of establishing a PROMIS-based registry using our project design and workflow was estimated at $2045, whereas the monthly maintenance cost was $1000.

Conclusion:

The routine electronic collection of PROMIS scores in the ambulatory orthopaedic clinic resulted in a compliance rate of over 90%, although older patients were generally less compliant than younger patients. Our system of data collection is practical and efficient in a high-volume orthopaedic clinic and places minimal financial burden on the provider.
Developing Change Readiness: A Video-Based Classroom Exercise
Authors: Varma Virajanand
Published: January 2019

Leading change is a significant element of a management career, and therefore, discussions on change management are integral to leadership and organizational behavior courses in business programs. However, given their limited work experiences with organizational transitions, most business students fail to appreciate the challenge involved in getting others to accept and implement the change. This classroom activity serves to help students better understand the concerns of change recipients when a top-down change is mandated. The assignment involves students watching an organizational change video in class, discussing in groups, identifying the different change readiness sentiments, and responding to a brief questionnaire. Students find the activity both challenging and exciting, and it gives the students an opportunity to appreciate various concerns related to change implementation. This exercise can be used with a range of courses in management curricula, both undergraduate and graduate, and in other leadership training modules.
How I treat refractory chronic graft-versus-host disease
Authors: Sarantopoulos Stefanie , Cardones Adela R. , Sullivan Keith M.
Published: January 2019

Approximately 35% to 50% of patients otherwise cured of hematologic malignancies after allogeneic hematopoietic stem cell transplantation will develop the pleomorphic autoimmune-like syndrome known as chronic graft-versus-host disease (cGVHD). Since in 2005, National Institutes of Health (NIH) consensus panels have proposed definitions and classifications of disease to standardize treatment trials. Recently, the first agent was approved by the US Food and Drug Administration for steroid-refractory cGVHD. Despite these advances, most individuals do not achieve durable resolution of disease activity with initial treatment. Moreover, standardized recommendations on how to best implement existing and novel immunomodulatory agents and taper salvage agents are often lacking. Given the potential life-threatening nature of cGVHD, we employ in our practice patient assessment templates at each clinic visit to elucidate known prognostic indicators and red flags. We find NIH scoring templates practical for ongoing assessments of these complex patient cases and determination of when changes in immunosuppressive therapy are warranted. Patients not eligible or suitable for clinical trials have systemic and organ-directed adjunctive treatments crafted in a multidisciplinary clinic. Herein, we review these treatment options and offer a management and monitoring scaffold for representative patients with cGVHD not responding to initial therapy.
Treatment of MDS
Authors: Platzbecker Uwe
Published: January 2019

The heterogeneous nature of myelodysplastic syndromes (MDS) demands a complex and personalized variety of therapeutic approaches. Among them, allogeneic hematopoietic stem cell transplantation remains the only potentially curative option and is accessible to only a small number of fit patients. For the majority of patients with MDS, treatment strategies are nonintensive and risk-adapted (by the revised version of the International Prognostic Scoring System), ranging from iron chelation and growth factors to lenalidomide and hypomethylating agents. These approaches are noncurative and aimed instead at improving cytopenias and quality of life and delaying disease progression. These limitations underpin the need for more translational research-based clinical trials in well-defined subgroups of patients with MDS. Indeed, much progress has been made over the past decade in understanding the complex molecular mechanisms underlying MDS. Unfortunately, this has not yet translated into approval of novel treatment options. There is a particularly urgent medical need in patients failing current first-line therapies, such as with erythropoiesis-stimulating or hypomethylating agents. Nevertheless, actual developments are expected to pave the way for exciting novel therapeutic opportunities. This review provides an overview of the current therapeutic landscape in MDS focusing on recent advances in clinical and translational research.
Juvenile myelomonocytic leukemia: who’s the driver at the wheel?
Authors: Niemeyer Charlotte M. , Flotho Christian
Published: January 2019

Juvenile myelomonocytic leukemia (JMML) is a unique clonal hematopoietic disorder of early childhood. It is classified as an overlap myeloproliferative/myelodysplastic neoplasm by the World Health Organization and shares some features with chronic myelomonocytic leukemia in adults. JMML pathobiology is characterized by constitutive activation of the Ras signal transduction pathway. About 90% of patients harbor molecular alterations in 1 of 5 genes (PTPN11, NRAS, KRAS, NF1, or CBL), which define genetically and clinically distinct subtypes. Three of these subtypes, PTPN11-, NRAS-, and KRAS-mutated JMML, are characterized by heterozygous somatic gain-of-function mutations in nonsyndromic children, whereas 2 subtypes, JMML in neurofibromatosis type 1 and JMML in children with CBL syndrome, are defined by germline Ras disease and acquired biallelic inactivation of the respective genes in hematopoietic cells. The clinical course of the disease varies widely and can in part be predicted by age, level of hemoglobin F, and platelet count. The majority of children require allogeneic hematopoietic stem cell transplantation for long-term leukemia-free survival, but the disease will eventually resolve spontaneously in ∼15% of patients, rendering the prospective identification of these cases a clinical necessity. Most recently, genome-wide DNA methylation profiles identified distinct methylation signatures correlating with clinical and genetic features and highly predictive for outcome. Understanding the genomic and epigenomic basis of JMML will not only greatly improve precise decision making but also be fundamental for drug development and future collaborative trials.
Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets
Authors: Jing Weidong , Yabas Mehmet , Bröer Angelika , Coupland Lucy , Gardiner Elizabeth E. , Enders Anselm , Bröer Stefan
Published: January 2019

The asymmetric distribution of phospholipids in the plasma/organellar membranes is generated and maintained through phospholipid flippases in resting cells, but becomes disrupted in apoptotic cells and activated platelets, resulting in phosphatidylserine (PS) exposure on the cell surface. Stable PS exposure during apoptosis requires inactivation of flippases to prevent PS from being reinternalized. Here we show that flippase ATP8A1 is highly expressed in both murine and human platelets, but is not present in the plasma membrane. ATP8A1 is cleaved by the cysteine protease calpain during apoptosis, and the cleavage is prevented indirectly by caspase inhibition, involving blockage of calcium influx into platelets and subsequent calpain activation. In contrast, in platelets activated with thrombin and collagen and exposing PS, ATP8A1 remains intact. These data reveal a novel mechanism of flippase cleavage and suggest that flippase activity in intracellular membranes differs between platelets undergoing apoptosis and activation.
Applications of low-rank compressed seismic data to full-waveform inversion and extended image volumes
Authors: Da Silva Curt , Zhang Yiming , Kumar Rajiv , Herrmann Felix J.
Published: January 2019

Conventional oil and gas fields are increasingly difficult to explore and image, resulting in the call for more complex wave-equation-based inversion algorithms that require dense long-offset samplings. Consequently, there is an exponential growth in the size of data volumes and prohibitive demands on computational resources. We have developed a method to compress and process seismic data directly in a low-rank tensor format, which drastically reduces the amount of storage required to represent the data. Seismic data exhibit a low-rank structure in a particular transform domain, which can be exploited to compress the dense data in one extremely storage-efficient tensor format when the data are fully sampled or can be interpolated when the data have missing entries. In either case, once our data are represented in the compressed tensor form, we have developed an algorithm to extract source or receiver gathers directly from the compressed parameters. This extraction process can be done on the fly directly on the compressed data, and it does not require scanning through the entire data set to form shot gathers. We apply this shot-extraction technique in the context of stochastic full-waveform inversion as well as forming full subsurface image gathers through probing techniques and reveal the minor differences between using the full and compressed data, while drastically reducing the total memory costs.
Semiempirical correlation between thermal conductivity and electrical resistivity for silt and silty clay soils
Authors: Sun Qiang , Lü Chao
Published: January 2019

Previous researchers have shown that thermal conductivity and electrical resistivity are related to the water content and void ratio of soil. The objective of this study is to present a theoretical relationship between these two physical parameters. A de Vries equation and Archie’s law are applied to develop a new theoretical equation that relates thermal conductivity to the electrical resistivity of soil. The DRE-2C thermal conductivity tester, which uses a transient plane-source method, is used to measure the thermal conductivity. In addition, the DDC-8 resistivity meter is used to measure the electrical resistivity. Experiments on the thermal conductivity and electrical resistivity of silt soil and silty clay soil with different gravimetric water contents and densities are performed. The results indicate that the theoretical equation can well explain the relationship between the thermal conductivity and electrical resistivity of silt and silty clay soils. The thermal conductivity and electrical resistivity are also found to have a linear relationship with the density of silt soil. When the gravimetric water content is less than 30%, the thermal conductivity and electrical resistivity of silty clay soil increase linearly with the density. The thermal conductivity increases with the gravimetric water content to a critical threshold depending on the soil type. The silty clay samples with a water content of 20% have the largest value of thermal conductivity. The electrical resistivity of the silt and silty clay samples decreases rapidly due to the increased pore connectivity and enhanced hydration of ions in soil with the increased water content. The results of the experiments indicate that the new theoretical equation is effective for estimating the soil electrical resistivity from the soil thermal conductivity.
Effective medium modeling of diagenesis impact on the petroacoustic properties of carbonate rocks
Authors: Adelinet Mathilde , Barthélémy Jean-François , Bemer Elisabeth , Hamon Youri
Published: January 2019

Carbonate formations are highly heterogeneous, and the velocity-porosity relationships are controlled by various microstructural parameters, such as the types of pores and their distribution. Because diagenesis is responsible for important changes in the microstructure of carbonate rocks, we have extended the standard effective medium approach to model the impact of diagenesis on the carbonate elastic properties through a step-by-step effective medium modeling. Two different carbonate rocks deposited, respectively, in lacustrine and marine environments are considered in this study. The first key step is the characterization of the diagenesis, which affected the two studied carbonate sample sets. Effective medium models integrating all of the geologic information accessible from petrographic analysis are then built. The evolution of the microstructural parameters during diagenesis is thoroughly constrained based on an extensive experimental data set, including X-ray diffraction analysis, different porosimetry methods, and ultrasonic velocity measurements. A new theoretical approach including two sources of compliance is developed to model the specific behavior of carbonates. A compliant interface is introduced around the main carbonate grains to represent grain contacts and the different pore scales are taken into account through multiscale modeling. Finally, direct calculations with the model provide elastic wave velocities representative of the different diagenetic stages. An extrapolation to permeability evolution is also introduced. This approach allows the identification of the acoustic signature of specific diagenetic events, such as dolomitization, dissolution, or cementation, and the assessment of their impact on the elastic properties of carbonates.
A subsampled truncated-Newton method for multiparameter full-waveform inversion
Authors: Matharu Gian , Sacchi Mauricio
Published: January 2019

Accounting for the Hessian in full-waveform inversion (FWI) can lead to higher convergence rates, improved resolution, and better mitigation of parameter trade-off in multiparameter problems. In spite of these advantages, the adoption of second-order optimization methods (e.g., truncated Newton [TN]) has been precluded by their high computational cost. We propose a subsampled TN (STN) algorithm for time-domain FWI with applications presented for the elastic isotropic case. By using uniform or nonuniform source subsampling during the computation of Hessian-vector products, we reduce the number of partial differential equation solves required per iteration when compared to the conventional TN algorithm. We evaluate the performance of STN through synthetic inversions on the Marmousi II and BP 2.5D models, using the limited-memory Broyden–Fletcher–Goldfarb–Shanno and TN algorithms as benchmarks. We determine that STN reaches a target misfit reduction at an overall cost comparable to first-order gradient methods, while retaining favorable convergence properties of TN methods. Furthermore, we evaluate an example in which nonuniform sampling outperforms uniform sampling in STN due to highly nonuniform source contributions to the Hessian.
Analyzing the architecture of point bar of meandering fluvial river using ground penetration radar: A case study from Hulun Lake Depression, China
Authors: Yue Dali , Li Wei , Wang Wurong , Hu Guangyi , Shen Bingbei , Wang Wenfeng , Zhang Manling , Hu Jiajing
Published: January 2019

The point bar is one of the most important reservoirs in a meandering depositional system, and accurately building a 3D architecture model for point bars is crucial to predict hydrocarbon distribution within the reservoir. Unfortunately, we can only obtain a qualitative description about the internal architecture of the point bar due to the limited information or the low resolution of available data (such as reflection seismic data). To build a 3D prototype point bar reservoir model, we analyze the architecture of point bars by integrating high-resolution ground penetrating radar (GPR) data and modern deposition. We found that our GPR data have five main reflection patterns (GPR facies), and GPR facies can be used to relate with architectural elements (the depositional facies and geobodies within depositional facies). The concave-down GPR facies is usually related to the abandoned channel. The continuous, subhorizontal, subparallel GPR facies is commonly related with lateral-accretion sand bodies within the point bar. The multiple stacked small-scale, discontinuous reflections GPR facies is interpreted to be shale drapes within the point bar. We further analyzed the geometry parameters of the identified channels. We found that the nonsymmetric [Formula: see text] of abandoned channel near the channel axis is related to the ratio between the curvature of channel radius [Formula: see text] and channel width [Formula: see text] ([Formula: see text]). Finally, we built two 3D channel reservoir models and our models could provide useful guidance for the architecture analysis of buried meandering fluvial reservoirs.
Decreasing Inappropriate Use of Rasburicase to Promote Cost-Effective Care
Authors: Patel Komal K. , Brown Timothy J. , Gupta Arjun , Roberts Taylor , Marley Eileen , Li Hsiao C. , Sadeghi Navid
Published: January 2019

BACKGROUND:

Rasburicase is a recommended treatment of tumor lysis syndrome and patients at high-risk for developing tumor lysis syndrome. Unfortunately, it is expensive, and unnecessary use raises costs of care.

METHODS:

Plan, Do, Study, Act methodology was used to decrease the inappropriate use of rasburicase. In the Plan phase, a multidisciplinary quality improvement team reviewed the rasburicase ordering process and its prescription patterns at Parkland Health and Hospital System between October 2015 and September 2017 to determine appropriate interventions for improvement. In the Do phase, interventions were deployed to improve rasburicase prescriptions. In the Study phase, the team reviewed the rasburicase orders and appropriateness from February 2018 to October 2018. During the Act phase, the interventions were found to be successful, and the process changes were solidified.

RESULTS:

At baseline, 65 doses of rasburicase were administered during the 2-year baseline period, 21 of these (32.3%) were inappropriate. Review of the ordering process identified pitfalls: one-click ready-to-sign order, fixed default dose, no hard-stop alert requiring physicians to review and confirm appropriate indications, and lack of secondary pharmacy review. We aimed to reduce the percentage of inappropriate rasburicase orders from a baseline of 32.3% to 10% over 3 months. In February 2018, we implemented the interventions, which resulted in reduction in inappropriate rasburicase use, with only a single inappropriate order placed in 7 months postintervention.

CONCLUSION:

A multidisciplinary approach and classic quality improvement methodology enabled us to reduce inappropriate rasburicase use. Straightforward electronic medical record interventions and secondary pharmacy review are effective in addressing overuse.
The regulatory pathway from genes directly activated by maternal factors to muscle structural genes in ascidian embryos
Authors: Yu Deli , Oda-Ishii Izumi , Kubo Atsushi , Satou Yutaka
Published: January 2019

Striated muscle cells in the tail of ascidian tadpole larvae differentiate cell-autonomously. Although several key regulatory factors have been identified, the genetic regulatory pathway is not fully understood; comprehensive understanding of the regulatory pathway is essential for accurate modeling in order to deduce principles for gene regulatory network dynamics, and for comparative analysis on how ascidians have evolved the cell-autonomous gene regulatory mechanism. Here, we reveal regulatory interactions among three key regulatory factors, Zic-r.b, Tbx6-r.b and Mrf, and elucidate the mechanism by which these factors activate muscle structural genes. We reveal a cross-regulatory circuit among these regulatory factors, which maintains the expression of Tbx6-r.b and Mrf during gastrulation. Although these two factors combinatorially activate muscle structural genes in late-stage embryos, muscle structural genes are activated mainly by Tbx6-r.b before gastrulation. Time points when expression of muscle structural genes become first detectable are strongly correlated with the degree of Tbx6-r.b occupancy. Thus, the genetic pathway, starting with Tbx6-r.b and Zic-r.b, which are activated by maternal factors, and ending with expression of muscle structural genes, has been revealed.
An essential role for dNTP homeostasis following CDK-induced replication stress
Authors: Pai Chen-Chun , Hsu Kuo-Feng , Durley Samuel C. , Keszthelyi Andrea , Kearsey Stephen E. , Rallis Charalampos , Folkes Lisa K. , Deegan Rachel , Wilkins Sarah E. , Pfister Sophia X. , De León Nagore , Schofield Christopher J. , Bähler Jürg , Carr Antony M. , Humphrey Timothy C.
Published: January 2019

Replication stress is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent kinase (CDK)-induced replication stress, resulting from Wee1 inactivation, is synthetic lethal with mutations disrupting dNTP homeostasis in fission yeast. Wee1 inactivation leads to increased dNTP demand and replication stress through CDK-induced firing of dormant replication origins. Subsequent dNTP depletion leads to inefficient DNA replication, DNA damage and to genome instability. Cells respond to this replication stress by increasing dNTP supply through histone methyltransferase Set2-dependent MBF-induced expression of Cdc22, the catalytic subunit of ribonucleotide reductase (RNR). Disrupting dNTP synthesis following Wee1 inactivation, through abrogating Set2-dependent H3K36 tri-methylation or DNA integrity checkpoint inactivation results in critically low dNTP levels, replication collapse and cell death, which can be rescued by increasing dNTP levels. These findings support a ‘dNTP supply and demand’ model in which maintaining dNTP homeostasis is essential to prevent replication catastrophe in response to CDK-induced replication stress.
Impact of different image reconstructions on PET quantification in non-small cell lung cancer: a comparison of adenocarcinoma and squamous cell carcinoma
Authors: Messerli Michael , Kotasidis Fotis , Burger Irene A. , Ferraro Daniela A. , Muehlematter Urs J. , Weyermann Corina , Kenkel David , von Schulthess Gustav K. , Kaufmann Philipp A. , Huellner Martin W.
Published: January 2019

Objective:

Positron emission tomography (PET) using 18F-fludeoxyglucose (18F-FDG) is an established imaging modality for tumor staging in patients with non-small cell lung cancer (NSCLC). There is a growing interest in using 18F-FDG PET for therapy response assessment in NSCLC which relies on quantitative PET parameters such as standardized uptake values (SUV). Different reconstruction algorithms in PET may affect SUV. We sought to determine the variation of SUV in patients with NSCLC when using ordered subset expectation maximization (OSEM) and block sequential regularized expectation maximization (BSREM) in latest-generation digital PET/CT, including a subanalysis for adenocarcinoma and squamous cell carcinoma.

Methods:

A total of 58 patients (34 = adenocarcinoma, 24 = squamous cell carcinoma) who underwent a clinically indicated 18F-FDG PET/CT for staging were reviewed. PET images were reconstructed with OSEM and BSREM reconstruction with noise penalty strength β-levels of 350, 450, 600, 800 and 1200. Lung tumors maximum standardized uptake value (SUVmax) were compared.

Results:

Lung tumors SUVmax were significantly lower in adenocarcinomas compared to squamous cell carcinomas in all reconstructions evaluated (all p < 0.01). Comparing BSREM to OSEM, absolute SUVmax differences were highest in lower β-levels of BSREM with + 2.9 ± 1.6 in adenocarcinoma and + 4.0 ± 2.9 in squamous cell carcinoma (difference between histology; p-values > 0.05). There was a statistically significant difference of the relative increase of SUVmax in adenocarcinoma (mean + 34.8%) and squamous cell carcinoma (mean 23.4%), when using BSREM350 instead of OSEMTOF (p < 0.05).

Conclusion:

In NSCLC the relative change of SUV when using BSREM instead of OSEM is significantly higher in adenocarcinoma as compared to squamous cell carcinoma.

Advances in knowledge:

The impact of BSREM on SUV may vary in different histological subtypes of NSCLC. This highlights the importance for careful standardization of β-value used for serial 18F-FDG PET scans when following-up NSCLC patients.
Case Report: Rare presentation of De Garengeot Hernia
Authors: Crawley-Smith Tom
Published: January 2019

The presentation of an incarcerated appendix within a femoral hernia accounts for 0.5-3.3% of all femoral hernias. It is rarely apparent diagnostically prior to surgery. A 48-year-old female had a delayed presentation with a 3-day history of an irreducible right inguinal swelling. Imaging failed to elucidate an incarcerated appendix, which was found at operation. The patient made a full recovery. The rarity and presentation of this condition is discussed. On literature review it typically is not suspected at operation due to its rarity and the difficulty of interpreting it on examination and imaging.
Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS
Authors: Hestiantoro Andon , Karimah Putri Deva , Shadrina Amalia , Wiweko Budi , Muharam R. , Astuti Brilliant Putri Kusuma
Published: January 2019

Background: Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, affecting 5-20% of women worldwide. Hyperandrogenism, as the primary characteristic of PCOS, is not always present in every patient. The hyperandrogenic phenotype of PCOS patients is influenced by both hormonal and metabolic dysfunctions. Therefore, this study aims to determine the correlation between hormone profile, lipid profile, and clinical profile with free testosterone index in subjects with PCOS.

Methods: This prospective cross-sectional study was conducted in the Dr. Cipto Mangunkusumo General Hospital between July 2014 and December 2016. The study involved 76 women with PCOS, who were classified into 2 subgroups: 39 subjects in the hyperandrogenism group and 37 subjects in the non-hyperandrogenism group. Each subject underwent physical examination, blood sample collection, and USG examination. Bivariate analysis was done using independent t-tests and Mann Whitney U-tests, while multivariate analysis was done using logistic regression.

Results: Triglyceride and testosterone level showed weak (r = 0.232, p = 0.044) and moderate (r = 0.460, p ¡ 0.001) positive correlation with FTI, while SHBG level showed moderate negative correlation (r = -0.483, p ¡ 0.001). Triglyceride was also found to be determinant of hyperandrogenism condition in PCOS patient (OR 0.02, 95% CI 0.00–0.04, p = 0.013). However, there was no significant difference observed between FGS and hyperandrogenism (p = 0.43).

Conclusions: Triglycerides, testosterone, and SHBG were associated with hyperandrogenism in PCOS patients, while FGS showed no such association.
A high dose of total recombinant FSH suppresses granulosa cell apoptosis and maintains oocyte quality in endometriosis: A cross-sectional study
Authors: Wiweko Budi , Mohammad Yassin Yanuar , Muna Naylah , Mutia Kresna , Witjaksono Julianto , Adi Nuri Purwito , Maidarti Mila , Harzif Achmad Kemal , Pratama Gita , Sumapraja Kanadi , Muharam R. , Hestiantoro Andon
Published: January 2019

Background: Endometriosis is one of the most common conditions causing infertility and an indication to undergo in vitro fertilization (IVF). High apoptosis rate and oxidative stress in patients with endometriosis are believed to negatively affect the IVF success rate. However, there have been conflicting results on the effect of endometriosis on IVF success, and there have been limited studies that directly assess endometriosis and its effect on oocyte quality. This study was performed to explore the correlation between mRNA BAX/BCL-2 expression and oocyte quality in endometriosis compared to non-endometriosis subjects.

Methods: This was a cross-sectional study. 15 endometriosis and 15 non-endometriosis subjects were recruited through convenience sampling at Cipto Mangunkusumo Hospital, Jakarta. All subjects underwent follicle stimulation with recombinant follicle-stimulating hormone (FSH). Granulosa cells were collected and tested for BAX and BCL-2 expression and the results were compared to the oocyte quality and fertilization rate of the patients.

Results: The total dose of recombinant FSH received by the endometriosis group was significantly higher compared with that of the non-endometriosis group (p = 0.005). There was a difference in BAX level (p = 0.029) and BCL-2 level (p<0.001) between groups. However, the BAX/BCL-2 ratio did not differ significantly (p = 0.787) between groups. No significant correlation was found between the BAX/BCL-2 ratio and any of the oocyte quality parameters measured.

Conclusion: We found that there is a significantly higher dose in total dose recombinant FSH received by the endometriosis group compared with the non-endometriosis group. We also found that there was no significant difference in BAX/BCL-2 ratio between the endometriosis and non-endometriosis groups.
Biomedicine, self and society: An agenda for collaboration and engagement
Authors: Pickersgill Martyn , Chan Sarah , Haddow Gill , Laurie Graeme , Sridhar Devi , Sturdy Steve , Cunningham-Burley Sarah
Published: January 2019

The commitment of massive resources – financial, social, organisational, and human – drives developments in biomedicine. Fundamental transformations in the generation and application of knowledge are challenging our understandings and experiences of health, illness, and disease as well as the organisation of research and care. Coupled with the accelerated pace of change, it is pressing that we build authentic collaborations across and between the biomedical sciences, humanities and social sciences, and wider society. It is only in this way that we can ask and answer the penetrating questions that will shape improvements in human health now and in the decades ahead. We delineate the need for such commitments across five key areas of human and societal experience that impact on and are impacted by developments in biomedicine: disease; bodies; global movements and institutions; law; and, science-society engagements. Interactions between ideas, researchers, and communities across and within these domains can provide a way into creating the new knowledges, methods, and partnerships we believe are essential if the promises of biomedicine are to be realised.
El Discurso Capitalista Neoliberal desde una perspectiva lacaniana
Authors: Fair Hernán
Published: January 2019

Este trabajo analiza el modo de construir subjetividad política del capitalismo neoliberal desde herramientas de la teoría de los discursos de Jacques Lacan. Se concluye que durante los años noventa el neoliberalismo se constituyó como un nuevo Discurso Amo. El nuevo Amo se estructuró mediante una articulación aggiornada del Discurso Capitalista con el Discurso Universitario y una reformulación del Discurso del Amo Antiguo. A partir de las construcciones metafóricas y los mandatos superyoicos de sus representantes y voceros, este discurso fue investido de un goce y un plus de goce lenguajero y corporal. A su vez, el Amo se mostró transfiriendo una parte del goce al Esclavo-Trabajador mediante una fantasía de libertad para elegir de forma plena y autónoma en el mercado, participar horizontalmente con el patrón en el nuevo orden flexible y acceder, vía el sacrificio, a un futuro de derrame de las riquezas de los ricos. Esta ilusión de retorno del goce al Esclavo fortaleció la dominación política del Amo-Empresario. En el caso argentino, junto con lapermanencia de la Convertibilidad como objeto a causa de deseo, de Menem a De la Rúa (1989-2001) se encontró un cambio de registro en los mandatos superyoicos y en las fuentes de goce, dentro de un mismo Discurso Capitalista Neoliberal de disciplinamiento social.
La diáspora silenciosa: estudios sobre la tercera ola de migraciones colombianas al exterior (2005-2015)
Authors: Polo Alvis Sebastián , Serrano López Enrique
Published: January 2019

A pesar de que existe una larga tradición de migraciones al exterior en Colombia, durante los últimos diez años ha habido un aumento significativo como consecuencia de eventos y circunstancias que han transformado abruptamente las condiciones de vida de la población colombiana. Este artículo se enfoca en estudiar el desarrollo de las tendencias de la tercera ola migratoria de la población colombiana al exterior entre los años 2005 y 2015, revisando los crecimientos y decrecimientos de dicha población hacia los destinos tradicionales, así como en detectar la aparición de nuevos destinos, la naturaleza de las migraciones hacia estos y las estimaciones del número de colombianos en estos países durante este periodo.
Migraciones internacionales, fronteras y Estados. ¿Cómo interpretar el régimen de frontera desde América del Sur?
Authors: Alvites Baiadera Angélica Paola
Published: January 2019

En el artículo nos preguntamos cómo interpretar el régimen de frontera desde América del Sur. Para esto, reflexionamos sobre la posible relación entre migraciones internacionales, Estados y fronteras en el campo de los estudios migratorios, con el fin de construir categorías analíticamente situadas. Desde una metodología cualitativa, analizamos un conjunto de documentos vinculados a esta temática: declaraciones finales e informes técnicos de la Conferencia Suramericana sobre Migraciones (csm), así como resoluciones del Mercado Común del Sur (Mercosur) y de la Comunidad Andina e Naciones (can). Para el análisis de estos documentos, e interpretar el régimen de frontera de la región, construimos tres puntos de apoyo: la externalización asociada al proceso de regionalización de las políticas de control migratorio en Sudamérica; el cruce de un territorio nacional a otro, vinculado a los controles en puntos de frontera; y, por último, las fronteras de permanencia, enlazadas a los mecanismos estatales que estipulan los modos de residir “en destino”. Sudamérica se constituye como unasubregión del régimen de frontera global, que favorece y estimula, no sin conflictos y tensiones, políticas de control ordenado, integrado y planificado de las migraciones. En “las fronteras”, los controles distinguen a los migrantes pertenecientes a un Estado miembro de la can, del Mercosur o uno extraregional. De este modo, los sujetos quedan supeditados al estrato político que ocupa el Estado del cual son parte al fijar un modo diferencial para ingresar y permanecer “en destino” según origen nacional.
Documentos de Política Externa e de Segurança da Federação Russa após 2014: principais mudanças e implicações
Authors: Dall'Agnol Augusto César , Piccolli Larlecianne , Pereira Tito Barcellos
Published: January 2019

O presente artigo busca descrever e analisar as principais continuidades e alterações da Doutrina Militar, da Estratégia de Segurança Nacional e do Conceito de Política Externa da Rússia, bem como os imperativos para tais mudanças e a visão que a Rússia apresenta em relação ao sistema internacional após 2014.
Smart tattoo: technology for monitoring blood glucose in the future
Authors: Meetoo Danny , Wong Louise , Ochieng Bertha
Published: January 2019

New ways of measuring blood glucose bring hope of easing the burden of diabetes management for patients living with the conditions. The smart tattoo is an innovation that represents a nascent nanotechnology, which is designed to be implanted within the skin to provide continuous and reliable glucose detection for individuals diagnosed with diabetes. The potential benefits of the smart tattoo are compelling not only due to the potential of these nanodevices to prevent diabetic complications and decrease the related social costs, but also due to ease of use and relative user comfort. However, despite the advantages of the smart tattoo, it is important that health professionals, in embracing nanotechnology, understand the ethical implications of using these innovative devices.
National evaluation of safety peripheral intravenous catheters in a clinician-led project
Authors: Guerrero Maya Aquino
Published: January 2019

Studies have demonstrated that up to 90% of all inpatients require the insertion of some form of an intravenous (IV) access device to facilitate therapy administration, which has also become as an essential aide in diagnostics and monitoring. These devices, particularly peripheral IV cannulas (PIVCs) are not without risks and complications. The NHS is trying to improve the safety and quality of health care by implementing evidence-based practices and one way to reduce the risks of PIVC-related complications is by to choose devices that are fit for purpose. However, there is scarcity of rigorous studies into the clinical acceptability and design of PIVCs. This article presents an excerpt of a national evaluation undertaken by an independent team of NHS senior clinicians from different fields, commissioned by the Department of Health and Social Care into everyday healthcare consumables. The NHS Clinical Evaluation Team's work focused on quality, safety and value to promote efficiency and productivity in the NHS. The success of the team, which delivered more than 30 reports, has paved the way to embedding clinical engagement and collaboration within the NHS. Involving clinicians in procurement will both ensure and assure quality, safety and value for the NHS.
Bilateral dentigerous cysts: an updated literature review and report of a case with associated root resorption
Authors: Yonel Zehra , McIntosh Arathi Papineni , Donaldson Neil , Murphy Michael , Taneja Pankaj
Published: January 2019

Abstract: Dentigerous cysts, though common, rarely present bilaterally. The rarity of bilateral presentation is highlighted by a review of the literature which revealed a total of 77 published cases. This demonstrated that, although 29% were asymptomatic, 58% presented with swelling and 22% with pain. The majority of patients were treated with enucleation alone (73%); 17% were managed with marsupialisation, and 8% treated with a combination of surgical techniques. Of cases reported, 16% had resorption of adjacent teeth, with 8% describing resorption of permanent dentition. This highlights the importance of symptom recognition and appropriate radiographic investigation from the outset to allow prompt, appropriate treatment.

CPD/Clinical Relevance: Dentigerous cysts are the second most common type of odontogenic cyst, however, their bilateral presentation in a syndrome-free patient is rare. Early recognition of symptoms, knowledge of appropriate investigations and management options are vital for ensuring optimal patient outcome.
Choice of non-steroidal anti-inflammatory drugs in equine colic
Authors: Duz Marco
Published: January 2019

While non-steroidal anti-inflammatory drugs (NSAIDs) can be used to manage abdominal discomfort in horses, they also are often a valid diagnostic tool to aid decision making around the need for surgery or referral of these patients. Knowledge of the pharmacokinetic properties and licensing of available drugs in the UK is of pivotal importance to select the most appropriate NSAID for the patient. This review focuses on the relevant characteristics of NSAIDs licensed for treatment of colic in horses: flunixin meglumine, metamizole, meloxicam and ketoprofen. Other NSAIDs such as phenylbutazone and firocoxib are licensed for use in horses but not for the treatment of colic; their role with colic is evaluated in light of available literature.
Phantasmagoric City: Technologies of Immersion and Settler Histories in Montreal’s CitéMémoire
Authors: Chew May
Published: January 2019

This paper focuses on CitéMémoire, a multi-year outdoor exhibit located throughout historic Old Montreal. Organized around the confluence of Montreal’s 375th birthday, Canada’s Sesquicentennial, as well as Expo 67’s 50th anniversary, CitéMémoire uses large-scale interactive projections and augmented reality to tell the city’s history from the time of European contact onward. The exhibit’s technologies of immersion guide audiences through a spectacularized historical landscape, rendering notions of heritage and nation into palpable archives that audiences encounter directly through their bodies. This article demonstrates how archival and cultural technologies, which choreograph audiences’ bodily, imaginational, and affective positionalities, prove central to the ‘dreamwork’ of settler coloniality.
Record Shop
Authors: Heuvingh Nathan
Published: January 2019

Record Shop MKG127, Toronto, June 30 – August 11
Phenotypic Characterization and Distribution of Sensi-1 Agrinak Chicken
Authors: Iskandar Sofjan
Published: January 2019

The utilization of local chicken genetic resources in Indonesia is increasing after the government program to achieve food sovereignty including livestock products. In the year of 2017, the Indonesian Research Institute for Animal Production (IRIAP) released SenSi-1 Agrinak chicken breed to be used as commercial meat type of local chicken in Indonesia. This paper describes development and distribution of the SenSi-1 Agrinak. This breed was selected from the native breed of Sentul chicken, originated from Ciamis District of West Java Province. The Sentul male was selected to achieve average live weight of 1 kg/bird at 10 weeks of age, with grey (G) and black spotted white (BSW) plumage color and pea-comb type. After six generations of selection, SenSi-1 Agrinak was released as an improved local meat-type chicken breed. License to private local chicken breeders is expected to increase SenSi-1 Agrinak population and distribution. Collaboration with several Assessment Institutes for Agricultural Technology (AIAT) and implementation of #BEKERJA-Ministry of Agriculture program can accelerate population and distribution of SenSi-1 Agrinak chicken to farmers throughout Indonesia.
Application of Peptide for Improving Animal Health and Livestock Productivity
Authors: Kusumaningtyas Eni
Published: January 2019

The use of antibiotics as growth promoter has been banned in Indonesia. One potential alternative antibiotic is peptide compounds. Peptides composed of several amino acid monomers that bind through peptide or amide bonds. Peptides are found in natural or synthetic forms that can be used to improve animal health and livestock productivity. This paper discusses the application of peptides in animal health and livestock productivity and the possibility of their utilization in Indonesia. Antimicrobial peptides are used to overcome bacterial infections, especially that are resistant to antibiotics and to preserve semen. Peptide vaccine can be used to replace conventional vaccines, especially for malignant viruses such as foot and mouth disease virus (FMD). Other peptides are used for infectious diseases and diabetes diagnostic tool in animals, medical treatment and animal reproduction system. Some peptides can be isolated from venom and have several benefits as an alternative fiber sutures for surgery and pain relief. Peptide-based drugs are metabolized faster than other small molecules, therefore, reducing the risk of contamination in livestock products.
Comparison of Dijkstra dan Floyd-Warshall Algorithm to Determine the Best Route of Train
Authors: Dermawan Tri Setya
Published: January 2019

Abstract - The best route is the path found based on the minimum price of a train journey using the Dijkstra and Floyd-Warshall algorithms. This study aims to find out the comparison of Dijkstra and Floyd-Warshall algorithms in finding the best path on a train trip. The results of route discovery will be displayed in a web-based application using the PHP programming language and MySQL database. The results of these two algorithms are compared using 4 parameters: time complexity, memory complexity, level of completion and level of optimization.Based on the comparison results from the implementation that Dijkstra's algorithm has a time complexity of 81 faster than the Floyd-Warshall algorithm. For the memory complexity, Dijkstra's algorithm uses a memory of 512616 bytes less than the Floyd-Warshall algorithm for the executive category. Whereas for the economic category the Dijkstra algorithm uses a memory of 482488 bytes less than the Floyd-Warshall algorithm. For the level of completion of the two algorithms, there is no error. In addition, for the level of optimization the Dijkstra algorithm has advantages in this study, namely the data used is dynamic or variable data in each stage of the process.
Analysis of Personality Characteristic Using the Naïve Bayess Classifier Algorithm (Case Study Official Twitter of Basuki Tjahaja Purnama's and Anies Baswedan)
Authors: Harsehanto Ireicca Agustiorini , Wahyudi M. Didik R.
Published: January 2019

Abstract - This research uses data from social media Twitter based on the results of tweets from user_timeline @basuki_btp and @aniesbaswedan. This study uses 2100 tweet data. Data that has been collected is then pre-processed first and labeled manually. The next process is classification using the Naïve Bayess Classifier Algorithm using the Big Five Personality Theory. Based on the test results using 500 tweet data as training data and 1600 tweet data as testing data. The classification results obtained by using the Naïve Bayes Classifier Method and grouped in the "Big Five" personality groups: Openness, Conscientiousness, Extraversion, Agreeableness and Neuroticism on tweet data in Indonesian.