bluuebunny/crossref_metadata_2025 huggingface dataset:
C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer
Authors: Sasaki Kosuke , Takano Shigetsugu , Tomizawa Satoshi , Miyahara Yoji , Furukawa Katsunori , Takayashiki Tsukasa , Kuboki Satoshi , Takada Mamoru , Ohtsuka Masayuki
Published: June 2021

Background

Recent studies indicate that complement plays pivotal roles in promoting or suppressing cancer progression. We have previously identified C4b-binding protein α-chain (C4BPA) as a serum biomarker for the early detection of pancreatic ductal adenocarcinoma (PDAC). However, its mechanism of action remains unclear. Here, we elucidated the functional roles of C4BPA in PDAC cells and the tumor microenvironment.

Methods

We assessed stromal C4BPA, the C4BPA binding partner CD40, and the number of CD8+ tumor-infiltrating lymphocytes in resected human PDAC tissues via immunohistochemical staining. The biological functions of C4BPA were investigated in peripheral blood mononuclear cells (PBMCs) and human PDAC cell lines. Mouse C4BPA (mC4BPA) peptide, which is composed of 30 amino acids from the C-terminus and binds to CD40, was designed for further in vitro and in vivo experiments. In a preclinical experiment, we assessed the efficacy of gemcitabine plus nab-paclitaxel (GnP), dual immune checkpoint blockades (ICBs), and mC4BPA peptide in a mouse orthotopic transplantation model.

Results

Immunohistochemical analysis revealed that high stromal C4BPA and CD40 was associated with favorable PDAC prognosis (P=0.0005). Stromal C4BPA strongly correlated with the number of CD8+ tumor-infiltrating lymphocytes (P=0.001). In in vitro experiments, flow cytometry revealed that recombinant human C4BPA (rhC4BPA) stimulation increased CD4+ and CD8+ T cell numbers in PBMCs. rhC4BPA also promoted the proliferation of CD40-expressing PDAC cells. By contrast, combined treatment with gemcitabine and rhC4BPA increased PDAC cell apoptosis rate. mC4BPA peptide increased the number of murine T lymphocytes in vitro and the number of CD8+ tumor-infiltrating lymphocytes surrounding PDAC tumors in vivo. In a preclinical study, GnP/ICBs/mC4BPA peptide treatment, but not GnP treatment, led to the accumulation of a greater number of CD8+ T cells in the periphery of PDAC tumors and to greater tumor regression than did control treatment.

Conclusions

These findings demonstrate that the combination of GnP therapy with C4BPA inhibits PDAC progression by promoting antitumor T cell accumulation in the tumor microenvironment.
Standard induction with basiliximab versus no induction in low immunological risk kidney transplant recipients: study protocol for a randomized controlled trial
Authors: Ajlan Aziza , Aleid Hassan , Ali Tariq Zulfiquar , Joharji Hala , Almeshari Khalid , Nazmi Ahmed Mohammed , Shah Yaser , Devol Edward , Alkortas Dalal , Alabdulkarim Zinah , Broering Dieter , Alahmadi Ibrahim , Ullah Asad , Alotaibi Anwar , Aljedai Ahmed
Published: June 2021

Background

Induction therapy with IL-2 receptor antagonist (IL2-RA) is recommended as a first-line agent in low immunological risk kidney transplant recipients. However, the role of IL2-RA in the setting of tacrolimus-based immunosuppression has not been fully investigated.

Aims

To compare different induction therapeutic strategies with 2 doses of basiliximab vs. no induction in low immunologic risk kidney transplant recipients as per KFSHRC protocol.

Methods

Prospective, randomized, double blind, non-inferiority, controlled clinical trial

Expected outcomes

1. Primary outcomes:

Biopsy-proven acute rejection within first year following transplant

2. Secondary outcomes:

a. Patient and graft survival at 1 year

b. eGFR at 6 months and at 12 months

c. Emergence of de novo donor-specific antibodies (DSAs)

Trial registration

The study has been prospectively registered at clinicaltrials.gov (NTC: 04404127). Registered on 27 May 2020.
The effect of the mobile “blood pressure management application” on hypertension self-management enhancement: a randomized controlled trial
Authors: Bozorgi Ali , Hosseini Hamed , Eftekhar Hassan , Majdzadeh Reza , Yoonessi Ali , Ramezankhani Ali , Mansouri Mehdi , Ashoorkhani Mahnaz
Published: June 2021

Background

Self-management of hypertension is of great significance given its increasing incidence and its associated disabilities. In view of the increased use of mobile health in medicine, the present study evaluated the effect of a self-management application on patient adherence to hypertension treatment.

Methods

This clinical trial was performed on 120 hypertensive patients who were provided with a mobile intervention for 8 weeks and followed up until the 24th week. Data on the primary outcome (adherence to treatment) and secondary outcomes (adherence to the DASH diet, regular monitoring of blood pressure, and physical activity) were collected using a questionnaire and a mobile application, respectively. The inter-group change difference over time was analyzed using repeated measures ANOVA (general linear model).

Results

The treatment adherence score increased by an average of 5.9 (95% CI 5.0–6.7) in the intervention group compared to the control group. The scores of “adherence to the low-fat and low-salt diet plans” were 1.7 (95% CI 1.3–2.1) and 1.5 (95% CI 1.2–1.9), respectively. Moreover, moderate physical activity increased to 100.0 min (95% CI 61.7–138.3) per week in the intervention group.

Conclusion

The treatment and control of blood pressure require a multifaceted approach given its complexity and multifactorial nature. Considering the widespread use of smartphones, mHealth interventions can be effective in self-management and better patient adherence to treatments. Our results showed that this application can be used as a successful tool for hypertension self-management in patients attending public hospitals in developing countries.

Trial registration

Iran Randomized Clinical Trial Center IRCT2015111712211N2. Registered on 1 January 2016
A GH89 human α-N-acetylglucosaminidase (hNAGLU) homologue from gut microbe Bacteroides thetaiotaomicron capable of hydrolyzing heparosan oligosaccharides
Authors: Yang Xiaohong , Yang Xiaoxiao , Yu Hai , Na Lan , Ghosh Tamashree , McArthur John B. , Chou Tsui-Fen , Dickson Patricia , Chen Xi
Published: June 2021

Carbohydrate-Active enZYme (CAZY) GH89 family enzymes catalyze the cleavage of terminal α-N-acetylglucosamine from glycans and glycoconjugates. Although structurally and mechanistically similar to the human lysosomal α-N-acetylglucosaminidase (hNAGLU) in GH89 which is involved in the degradation of heparan sulfate in the lysosome, the reported bacterial GH89 enzymes characterized so far have no or low activity toward α-N-acetylglucosamine-terminated heparosan oligosaccharides, the preferred substrates of hNAGLU. We cloned and expressed several soluble and active recombinant bacterial GH89 enzymes in Escherichia coli. Among these enzymes, a truncated recombinant α-N-acetylglucosaminidase from gut symbiotic bacterium Bacteroides thetaiotaomicron ∆22Bt3590 was found to catalyze the cleavage of the terminal α1–4-linked N-acetylglucosamine (GlcNAc) from a heparosan disaccharide with high efficiency. Heparosan oligosaccharides with lengths up to decasaccharide were also suitable substrates. This bacterial α-N-acetylglucosaminidase could be a useful catalyst for heparan sulfate analysis.
Rapid-flow expulsion maneuver in subglottic secretion clearance to prevent ventilator-associated pneumonia: a randomized controlled study
Authors: Li Ying , Yuan Xue , Sun Bing , Li Hai-chao , Chu Hui-wen , Wang Li , Zhao Yu , Tang Xiao , Wang Rui , Li Xu-yan , Tong Zhao-hui , Wang Chen
Published: June 2021

Background

Following endotracheal intubation, clearing secretions above the endotracheal tube cuff decreases the incidence of ventilator-associated pneumonia (VAP); therefore, subglottic secretion drainage (SSD) is widely advocated. Our group developed a novel technique to remove the subglottic secretions, the rapid-flow expulsion maneuver (RFEM). The objective of this study was to explore the effectiveness and safety of RFEM compared with SSD.

Methods

This study was a single-center, prospective, randomized and controlled trial, conducted at Respiratory Intensive Care Unit (ICU) of Beijing Chao-Yang Hospital, a university-affiliated tertiary hospital. The primary outcome was the incidence of VAP, assessed for non-inferiority.

Results

Patients with an endotracheal tube allowing drainage of subglottic secretions (n = 241) were randomly assigned to either the RFEM group (n = 120) or SSD group (n = 121). Eleven patients (9.17%) in the RFEM group and 13 (10.74%) in the SSD group developed VAP (difference, − 1.59; 95% confidence interval [CI] [− 9.20 6.03]), as the upper limit of 95% CI was not greater than the pre-defined non-inferiority limit (10%), RFEM was declared non-inferior to SSD. There were no statistically significant differences in the duration of mechanical ventilation, ICU mortality, or ICU length of stay and costs between groups. In terms of safety, no accidental extubation or maneuver-related barotrauma occurred in the RFEM group. The incidence of post-extubation laryngeal edema and reintubation was similar in both groups.

Conclusions

RFEM is effective and safe, with non-inferiority compared to SSD in terms of the incidence of VAP. RFEM could be an alternative method in first-line treatment of respiratory ICU patients.

Trial registration This study has been registered on ClinicalTrials.gov (Registration Number: NCT02032849, https://clinicaltrials.gov/ct2/show/NCT02032849); registered on January 2014
Low birth weight as a predictor of adverse health outcomes during adulthood in twins: a systematic review and meta-analysis
Authors: Hassan Sapha , Jahanfar Shayesteh , Inungu Joseph , Craig Jeffrey M.
Published: June 2021

Background

Low birth weight might affect adverse health outcomes during a lifetime. Our study analyzes the association between low birth weight and negative health outcomes during adulthood in twin populations.

Methods

Searches were conducted using databases inclusive of MEDLINE, CINAHL, Web of Science, and EBSCO. Observational studies on twins with low birth weight and adverse health outcomes during adulthood were included. Two reviewers independently screened the papers, and a third reviewer resolved the conflicts between the two reviewers. Following abstract and title screening, full-texts were screened to obtain eligibility. Eligible full-text articles were then assessed for quality using a modified Downs and Black checklist. Studies with a score within one standard deviation of the mean were included in the analysis. A fixed-effect model was used for analysis.

Results

3987 studies were screened describing low birth weight as a risk factor for adverse health outcomes during adulthood for all twelve-body systems (circulatory, digestive, endocrine, lymphatic, muscular, nervous, reproductive, respiratory, skeletal, urinary, and integumentary systems). One hundred fourteen articles made it through full-text screening, and 14 of those articles were assessed for quality. Five papers were selected to perform two meta-analyses for two outcomes: asthma and cerebral palsy. For asthma, the meta-analyses of three studies suggested a higher odds of low birth weight twins developing asthma (OR 1.33, 95% CI 1.24-1.44, I2 = 77%). Meta-analysis for cerebral palsy included two studies and suggested a 4.88 times higher odds of low birth weight twins developing cerebral palsy compared to normal birth weight twins (OR 4.88, 95% CI 2.34-10.19, I2 = 79%). We could not find enough studies for other adverse health outcomes to pool data for a Forest plot.

Conclusions

The odds of low birth weight were found to be high in both asthma and cerebral palsy. There are not enough studies of similar nature (study types, similar body systems) to ensure a meaningful meta-analysis. We recommend that future research considers following up on twins to obtain data about adverse health outcomes during their adult lives.
The health impacts of preventive cardiovascular medication reduction on older populations: protocol for a systematic review and meta-analysis
Authors: van der Veen Rik S. , Lee Joseph J. , McManus Richard J. , Hobbs Richard F. D. , Mahtani Kamal R. , Koshiaris Constantinos , Sheppard James P.
Published: June 2021

Background

Polypharmacy is inevitable and appropriate for many conditions, but in some cases, it can be problematic resulting in an increased risk of harm and reduced quality of life. There has been an increasing interest to reduce cardioprotective medications in older adults to potentially reduce the risk of harm due to treatment; however, there is no evidence on safety and efficacy to support this practice currently. This paper describes a protocol for a systematic review on the safety and efficacy of reducing cardioprotective medication in older populations.

Methods

MEDLINE (PubMed), Embase (Ovid), and CENTRAL (Cochrane Central Register of Controlled Trials) will be searched from their inception onwards for relevant studies. Randomised controlled trials and non-randomised studies on interventions (prospective, retrospective cohort, case-control) conducted in older adults (75 years or older) examining reduction of cardioprotective medications will be included. The primary outcome of this study will be all-cause hospitalisation. Secondary outcome variables of interest are all-cause hospitalisation, mortality, quality of life, serious adverse events, major adverse cardiovascular events, falls, fractures, cognitive functioning, bleeding events, renal functioning, medication burden, drug reinstatement, time-in-hospital, and frailty status. Two reviewers will independently screen all citations, full-text articles, and extract data. Confidence in cumulative evidence will be assessed using the GRADE approach; the risk of bias will be assessed by the RoB-II tool for randomised controlled studies and ROBINS-I for non-randomised studies. Where sufficient data are available, we will conduct a random effects meta-analysis by combining the outcomes of the included studies. Sub-group analysis and meta-regression are planned to assess the potential harms and risks of different drug classes and the impacts in different patient populations (e.g. sex, cognitive status, renal status, and age).

Discussion

The study will be a comprehensive review on all published articles identified using our search strategy on the safety and efficacy of cardioprotective medication reduction in the older population. The findings will be crucial to inform clinicians on potential health outcomes of reducing cardiovascular medication in the elderly.

Systematic review registration

PROSPERO CRD42020208223
Exploring the socio-economic determinants of educational inequalities in diarrhoea among under-five children in low- and middle-income countries: a Fairlie decomposition analysis
Authors: Fagbamigbe Adeniyi Francis , Adebola Olukemi Grace , Dukhi Natisha , Fagbamigbe Omon Stellamaris , Uthman Olalekan A.
Published: June 2021

Background

What explains the underlying causes of educational inequalities in diarrhoea among under-five children in low- and middle-income countries (LMIC) is poorly exploited, operationalized, studied and understood. This paper aims to assess the magnitude of educational-related inequalities in the development of diarrhoea and decompose risk factors that contribute to these inequalities among under-five children (U5C) in LMIC.

Methods

Secondary data of 796,150 U5C from 63,378 neighbourhoods in 57 LMIC was pooled from the Demographic and Health Surveys (DHS) conducted between 2010 and 2019. The main determinate variable in this decomposition study was mothers’ literacy levels. Descriptive and inferential statistics comprising of bivariable analysis and binary logistic multivariable Fairlie decomposition techniques were employed at p = 0.05.

Results

Of the 57 countries, we found a statistically significant pro-illiterate odds ratio in 6 countries, 14 showed pro-literate inequality while the remaining 37 countries had no statistically significant educational-related inequality. The countries with pro-illiterate inequalities are Burundi (OR = 1.11; 95% CI: 1.01–1.21), Cameroon (OR = 1.84; 95% CI: 1.66–2.05), Egypt (OR = 1.26; 95% CI: 1.12–1.43), Ghana (OR = 1.24; 95% CI: 1.06–1.47), Nigeria (OR = 1.80; 95% CI: 1.68–1.93), and Togo (OR = 1.21; 95% CI: 1.06–1.38). Although there are variations in factors that contribute to pro-illiterate inequality across the 6 countries, the overall largest contributors to the inequality are household wealth status, maternal age, neighbourhood SES, birth order, toilet type, birth interval and place of residence. The widest pro-illiterate risk difference (RD) was in Cameroon (118.44/1000) while the pro-literate risk difference was widest in Albania (− 61.90/1000).

Conclusions

The study identified educational inequalities in the prevalence of diarrhoea in children with wide variations in magnitude and contributions of the risk factors to pro-illiterate inequalities. This suggests that diarrhoea prevention strategies is a must in the pro-illiterate inequality countries and should be extended to educated mothers as well, especially in the pro-educated countries. There is a need for further studies to examine the contributions of structural and compositional factors associated with pro-educated inequalities in the prevalence of diarrhoea among U5C in LMIC.
Disordered eating & body image of current and former athletes in a pandemic; a convergent mixed methods study - What can we learn from COVID-19 to support athletes through transitions?
Authors: Buckley Georgina Louise , Hall Linden Elizabeth , Lassemillante Annie-Claude M. , Belski Regina
Published: June 2021

Background

The COVID-19 pandemic has seen worsened mental health as a result of lockdowns, isolation and changes to sociocultural functioning. The postponement of the Tokyo 2020 Olympics is representative of global cancellations of sporting events, reduced facility access and support restrictions that have affected both current and former athlete’s psychological wellbeing. This study aimed to determine whether current (n = 93) and former (n = 111) athletes experienced worsened body image, relationship with food or eating disorder symptomatology during acute COVID-19 transitions.

Methods

The study was a Convergent Mixed Methods design whereby qualitative content analysis was collected and analysed simultaneously with quantitative cross-sectional data using the EAT-26 and self-report COVID-19 questions. Data were collected from April until May 2020 to capture data pertaining to transitions related to the pandemic and included individuals across 41 different individual and team sports from club to international competition levels.

Results

There was a surge in disordered eating in current and former athletes as a result of the early COVID-19 response. Eating disorders were suggested to occur in 21.1% of participants (18% current athletes n = 17, 25% former athletes (n = 26). There was a significant difference between males and females (p = 0.018, r = 0.17), but interestingly no differences between groups from individual vs team sports, type of sporting category (endurance, antigravitational, ball sport, power, technical and aesthetic) or level of competition (club, state, national or international). 34.8% (n = 69) self-reported worsened body image and 32.8% (n = 65) self-reported a worsened food relationship directly from COVID-19. Qualitative analysis indicated that disordered eating occurred predominantly in the form of body preoccupation, inhibitory food control, fear of body composition changes and binge eating.

Conclusions

This study indicates that transitions in COVID-19 have worsened food-body relationships in current and former athletes and must be treated as an at-risk time for eating disorder development. We suggest that resources are allocated appropriately to assist athletes to foster psychologically positive food and body relationships through COVID-19 transitions. This study makes practice suggestions in supporting athletes to manage control, seek support, adapt and accept change and promote connection and variety through athletic transitions.
Microwave ablation eustachian tuboplasty: A preliminary investigation with long-term follow-up
Authors: Lou Zhengcai , Lou Zihan , Sun Junzhi , Chen Zhengnong , Yin Shankai
Published: June 2021

Objectives

This study was performed to evaluate the efficacy of microwave ablation (MWA) eustachian tuboplasty for the treatment of patients with retracted tympanic membrane (TM) due to eustachian tube dysfunction (ETD).

Methods

This was a prospective study of 20 patients with ETD (middle ear atelectasis) who underwent MWA eustachian tuboplasty. Outcomes included the ability to perform a Valsalva maneuver, audiometry results, tympanometry results, ETD Questionnaire (ETDQ-7) score, and TM status.

Results

Eighteen patients (18 ears) were included in this study. There were statistically and clinically significant improvements in the mean ETDQ-7 score at 6 months postoperatively (change in mean score of 16.7 ± 3.6, P < 0.001) and at 30 months postoperatively (change in mean score of 18.9 ± 2.9, P < 0.001). Type A tympanogram was obtained in 27.8% of patients (5/18) at 6 months postoperatively, and in 77.7% at 30 months postoperatively. A Valsalva maneuver was possible in 72.2% of patients at 6 months postoperatively and in 88.9% of patients at 30 months postoperatively. In addition, the ears of 13 patients (72.2%) showed both normal tympanograms and TM at 30 months postoperatively. Interestingly, 38.5% of patients (5/13) exhibited complete sclerosis of the pars tensa. None of the patients experienced severe MWA-related complications during follow-up.

Conclusions

MWA eustachian tuboplasty is a feasible alternative to conventional tuboplasty, and can improve subjective and objective outcomes in patients with ETD for up to 30 months following treatment. In addition, this study showed that the extent of sclerotic plaque increased over time, whereas the extents of atrophy and tensa retraction decreased following tuboplasty in most patients.

Graphical Abstract
Real-time spatio-temporal event detection on geotagged social media
Authors: George Yasmeen , Karunasekera Shanika , Harwood Aaron , Lim Kwan Hui
Published: June 2021

A key challenge in mining social media data streams is to identify events which are actively discussed by a group of people in a specific local or global area. Such events are useful for early warning for accident, protest, election or breaking news. However, neither the list of events nor the resolution of both event time and space is fixed or known beforehand. In this work, we propose an online spatio-temporal event detection system using social media that is able to detect events at different time and space resolutions. First, to address the challenge related to the unknown spatial resolution of events, a quad-tree method is exploited in order to split the geographical space into multiscale regions based on the density of social media data. Then, a statistical unsupervised approach is performed that involves Poisson distribution and a smoothing method for highlighting regions with unexpected density of social posts. Further, event duration is precisely estimated by merging events happening in the same region at consecutive time intervals. A post processing stage is introduced to filter out events that are spam, fake or wrong. Finally, we incorporate simple semantics by using social media entities to assess the integrity, and accuracy of detected events. The proposed method is evaluated using different social media datasets: Twitter and Flickr for different cities: Melbourne, London, Paris and New York. To verify the effectiveness of the proposed method, we compare our results with two baseline algorithms based on fixed split of geographical space and clustering method. For performance evaluation, we manually compute recall and precision. We also propose a new quality measure named strength index, which automatically measures how accurate the reported event is.
Mesoporous activated carbon yielded from pre-leached cassava peels
Authors: Kayiwa R. , Kasedde H. , Lubwama M. , Kirabira J. B.
Published: June 2021

The search for alternatives to fossil-based commercial activated carbon (AC) continues to reveal new eco-friendly potential precursors, among which is agricultural waste. The key research aspect in all these endeavors is empirical ascertainment of the core properties of the resultant AC to suit a particular purpose. These properties include: yield, surface area, pore volume, and the active surface groups. It is therefore pertinent to have process conditions controlled and tailored towards these properties for the required resultant AC. Pre-leaching cassava peels with NaOH followed by KOH activation and carbonization at holding temperatures (780 °C) above the melting point of K (760 °C) yielded mesoporous activated carbon with the highest surface area ever reported for cassava peel-based AC. The carbonization temperatures were between 480 and 780 °C in an activation–carbonization stepwise process using KOH as the activator at a KOH:peel ratio of 5:2 (mass basis). A 42% maximum yield of AC was realized along with a total pore volume of 0.756 cm3g−1 and BET surface area of 1684 m2g−1. The AC was dominantly microporous for carbonization temperatures below 780 °C, but a remarkable increase in mesopore volume (0.471 cm3g−1) relative to the micropore volume (0.281 cm3g−1) was observed at 780 °C. The Fourier transform infrared (FTIR) spectroscopy for the pre-treated cassava peels showed distortion in the C–H bonding depicting possible elaboration of more lignin from cellulose disruption by NaOH. A carboxylate stretch was also observed owing to the reaction of Na+ ions with the carboxyl group in the raw peels. FTIR showed possible absorption bands for the AC between 1425 and 1712 cm−1 wave numbers. Besides the botanical qualities of the cassava peel genotype used, pre-leaching the peels and also increasing holding activation temperature above the boiling point of potassium enabled the modified process of producing highly porous AC from cassava peel. The scanning electron microscope (SEM) and transmission electron microscope (TEM) imaging showed well-developed hexagonal pores in the resultant AC and intercalated K profile in the carbon matrices, respectively.
Collection, curation and the use of humidification to restore nest shape in a research museum bird nest collection
Authors: Haff Tonya M. , Tees Natalie , Wood Kathryn , Cawsey E. Margaret , Joseph Leo , Holleley Clare E.
Published: June 2021

Background

Bird nests are an important part of avian ecology. They are a powerful tool for studying not only the birds that built them, but a wide array of topics ranging from parasitology, urbanisation and climate change to evolution. Despite this, bird nests tend to be underrepresented in natural history collections, a problem that should be redressed through renewed focus by collecting institutions.

Methods

Here we outline the history and current best practice collection and curatorial methods for the nest collection of the Australian National Wildlife Collection (ANWC). We also describe an experiment conducted on nests in the ANWC using ultrasonic humidification to restore the shape of nests damaged by inappropriate storage.

Results

The experiment showed that damaged nests can be successfully reshaped to close to their original dimensions. Indeed, restored nests were significantly closer to their original shape than they were prior to restoration. Thus, even nests damaged by years of neglect may be fully incorporated into active research collections. Best practice techniques include extensive note taking and photography in the field, subsampling of nests that cannot or should not be collected, appropriate field storage, metadata management, and prompt treatment upon arrival at the collection facility.

Conclusions

Renewed focus on nest collections should include appropriate care and restoration of current collections, as well as expansion to redress past underrepresentation. This could include collaboration with researchers studying or monitoring avian nesting ecology, and nest collection after use in bird species that rebuild anew each nesting attempt. Modern expansion of museum nest collections will allow researchers and natural history collections to fully realise the scientific potential of these complex and beautiful specimens.
Performance of wearables and the effect of user behavior in additive manufacturing process
Authors: Kwon JuYoun , Kim Namhun
Published: June 2021

Additive manufacturing (AM) which can be a suitable technology to personalize wearables is ideal for adjusting the range of part performance such as mechanical properties if high performance is not required. However, the AM process parameter can impact overall durability and reliability of the part. In this instance, user behavior can play an essential role in performance of wearables through the settings of AM process parameter. This review discusses parameters of AM processes influenced by user behavior with respect to performance required to fabricate AM wearables. Many studies on AM are performed regardless of the process parameters or are limited to certain parameters. Therefore, it is necessary to examine how the main parameters considered in the AM process affect performance of wearables. The overall aims of this review are to achieve a greater understanding of each AM process parameter affecting performance of AM wearables and to provide requisites for the desired performance including the practice of sustainable user behavior in AM fabrication. It is discussed that AM wearables with various performance are fabricated when the user sets the parameters. In particular, we emphasize that it is necessary to develop a qualified procedure and to build a database of each AM machine about part performance to minimize the effect of user behavior.
Cases of generalized low-frequency shadows of tight gas reservoirs
Authors: Pu Renhai , Han Qiang , Xu Pengye
Published: June 2021

The phenomenon that frequency decreases and amplitude increases near the bottom of a gas layer on a seismic profile is called a low-frequency shadow, but this phenomenon may not occur in all gas reservoirs. When the tight gas reservoir is thick enough, spectral decomposition data after Fourier transformation will indicate characteristics similar to those of low-frequency shadows, which we call generalized low-frequency shadows. Compared to the dominant frequency of the nongas-bearing zone spectral, the dominant frequency of a gas zone moves toward the low end of the frequency range and the low-frequency amplitude increases accordingly. By analyzing known gas reservoirs such as the Sulige and Yanchang tight sandstones in the Ordos Basin and tight carbonate rocks in the Tarim Basin, we can see that, with the visual dominant seismic frequency close to 30 Hz, the peak frequency of the gas-bearing tight sandstones and tight dolomite reservoirs will move from approximately 30 to 10–15 Hz. There is a certain correlation among the drop of the dominant frequency of a tight gas reservoir, the attenuation energy difference, and the thickness and productivity of the gas layer. Several cases indicate that nearly all tight gas layers thicker than 15 m exhibit attenuation characteristics of generalized low-frequency shadows.
Benefits and barriers to mentoring in psychiatry: a mentee's perspective
Authors: Hewson Thomas , Lagunes-Cordoba Emmeline , Tracy Derek K.
Published: June 2021

Mentoring is becoming increasingly recognised as a tool for supporting the junior workforce and for helping trainees to achieve their full potential. In this article we explore the benefits and barriers to mentoring in psychiatry from a trainee's perspective, and highlight differences between the role of a mentor and clinical and educational supervisor.
Investigating the causal nature of the relationship of subcortical brain volume with smoking and alcohol use
Authors: Logtenberg Emma , Overbeek Martin F. , Pasman Joëlle A. , Abdellaoui Abdel , Luijten Maartje , van Holst Ruth J. , Vink Jacqueline M. , Denys Damiaan , Medland Sarah E. , Verweij Karin J. H. , Treur Jorien L.
Published: June 2021

Background

Structural variation in subcortical brain regions has been linked to substance use, including the most commonly used substances nicotine and alcohol. Pre-existing differences in subcortical brain volume may affect smoking and alcohol use, but there is also evidence that smoking and alcohol use can lead to structural changes.

Aims

We assess the causal nature of the complex relationship of subcortical brain volume with smoking and alcohol use, using bi-directional Mendelian randomisation.

Method

Mendelian randomisation uses genetic variants predictive of a certain ‘exposure’ as instrumental variables to test causal effects on an ‘outcome’. Because of random assortment at meiosis, genetic variants should not be associated with confounders, allowing less biased causal inference. We used summary-level data of genome-wide association studies of subcortical brain volumes (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus; n = 50 290) and smoking and alcohol use (smoking initiation, n = 848 460; cigarettes per day, n = 216 590; smoking cessation, n = 378 249; alcoholic drinks per week, n = 630 154; alcohol dependence, n = 46 568). The main analysis, inverse-variance weighted regression, was verified by a wide range of sensitivity methods.

Results

There was strong evidence that liability to alcohol dependence decreased amygdala and hippocampal volume, and smoking more cigarettes per day decreased hippocampal volume. From subcortical brain volumes to substance use, there was no or weak evidence for causal effects.

Conclusions

Our findings suggest that heavy alcohol use and smoking can causally reduce subcortical brain volume. This adds to accumulating evidence that alcohol and smoking affect the brain, and likely mental health, warranting more recognition in public health efforts.
PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus
Authors: Szeto Ke Xu , Le Merdy Maxime , Dupont Benjamin , Bolger Michael B. , Lukacova Viera
Published: June 2021

The purpose of this study was to develop a physiologically based pharmacokinetic (PBPK) model predicting the pharmacokinetics (PK) of different compounds in pregnant subjects. This model considers the differences in tissue sizes, blood flow rates, enzyme expression levels, glomerular filtration rates, plasma protein binding, and other factors affected during pregnancy in both the maternal and fetal models. The PBPKPlus™ module in GastroPlus® was used to model the PK of cefuroxime and cefazolin. For both compounds, the model was first validated against PK data in healthy non-pregnant volunteers and then applied to predict pregnant groups PK. The model accurately described the PK in both non-pregnant and pregnant groups and explained well differences in the plasma concentration due to pregnancy. The fetal plasma and amniotic fluid concentrations were also predicted reasonably well at different stages of pregnancy. This work describes the use of a PBPK approach for drug development and demonstrates the ability to predict differences in PK in pregnant subjects and fetal exposure for compounds excreted renally. The prediction for pregnant groups is also improved when the model is calibrated with postpartum or non-pregnant female group if such data are available.
Robotic-arm-assisted flexible large field-of-view optical coherence tomography
Authors: Huang Yong , Li Xiaochen , Liu Junyu , Qiao Zhengyu , Chen Jingsi , Hao Qun
Published: June 2021

Optical coherence tomography (OCT) is a three-dimensional non-invasive high-resolution imaging modality that has been widely used for applications ranging from medical diagnosis to industrial inspection. Common OCT systems are equipped with limited field-of-view (FOV) in both the axial depth direction (a few millimeters) and lateral direction (a few centimeters), prohibiting their applications for samples with large and irregular surface profiles. Image stitching techniques exist but are often limited to at most 3 degrees-of-freedom (DOF) scanning. In this work, we propose a robotic-arm-assisted OCT system with 7 DOF for flexible large FOV 3D imaging. The system consists of a depth camera, a robotic arm and a miniature OCT probe with an integrated RGB camera. The depth camera is used to get the spatial information of targeted sample at large scale while the RGB camera is used to obtain the exact position of target to align the image probe. Eventually, the real-time 3D OCT imaging is used to resolve the relative pose of the probe to the sample and as a feedback for imaging pose optimization when necessary. Flexible probe pose manipulation is enabled by the 7 DOF robotic arm. We demonstrate a prototype system and present experimental results with flexible tens of times enlarged FOV for plastic tube, phantom human finger, and letter stamps. It is expected that robotic-arm-assisted flexible large FOV OCT imaging will benefit a wide range of biomedical, industrial and other scientific applications.
Aperiodic bandgap structures for enhanced quantum two-photon sources
Authors: Dal Negro Luca , Chen Yuyao , Gorsky Sean , Sgrignuoli Fabrizio
Published: June 2021

In this paper, we propose a novel approach to enhance the efficiency of
the two-photon spontaneous emission process that is driven by the
multifractal optical mode density of photonic structures based on the
aperiodic distributions of Eisenstein and Gaussian primes. In
particular, using the accurate Mie–Lorenz multipolar theory in
combination with multifractal detrended fluctuation analysis, we
compute the local density of states of periodic and aperiodic systems
and demonstrate the formation of complete bandgaps with distinctive
fractal scaling behavior for scattering arrays of dielectric
nanocylinders. Moreover, we systematically study the Purcell
enhancement and the most localized optical mode resonances in these
novel aperiodic photonic systems and compute their two-photon
spontaneous emission rates based on the general Green’s tensor
approach. Our results demonstrate that excitation of the highly
resonant critical states of Eisenstein and Gaussian photonic arrays
across broadband multifractal spectra gives rise to significantly
enhanced emission rates compared to what is possible at the band edges
of periodic structures with comparable size. Besides defining a novel
approach for enhanced quantum two-photon sources on the chip, the
engineering of aperiodic bandgap structures with multifractal mode
density may provide access to novel electromagnetic resonant phenomena
in a multi-scale-invariant vacuum for quantum nanophotonics
applications.
Deep learning control of THz QCLs
Authors: Limbacher Benedikt , Schoenhuber Sebastian , Kainz Martin Alexander , Bachelard Nicolas , Andrews Aaron Maxwell , Detz Hermann , Strasser Gottfried , Darmo Juraj , Unterrainer Karl
Published: June 2021

Artificial neural networks are capable of fitting highly non-linear and complex systems. Such complicated systems can be found everywhere in nature, including the non-linear interaction between optical modes in laser resonators. In this work, we demonstrate artificial neural networks trained to model these complex interactions in the cavity of a Quantum Cascade Random Laser. The neural networks are able to predict modulation schemes for desired laser spectra in real-time. This radically novel approach makes it possible to adapt spectra to individual requirements without the need for lengthy and costly simulation and fabrication iterations.
Significant optical force enhancements of nanostructure with balanced gain and loss
Authors: Zhang Xiaoming , Peng Yuqi , Lee Chern , Chu Xinhong , Xiao Yanping , Wang Haiyan , Xie Fang , Liu Jianping , Yuan Yijun
Published: June 2021

In this paper, we theoretically analyze the optical force between a pair of active and passive plasmonic core-shell nanoparticles (NPs). The optical force between the NPs can be either attractive or repulsive near the critical point while the passive dimer provides only attractive force. We reveal that the reversal of attractive or repulsive force is determined by the relative phase of electric dipole (ED) modes, which can be strongly affected by the gain and loss coefficient κ. Compared with the passive dimer with the same size, the active-passive dimer can exhibit a very high repulsive force (about two orders of magnitude) while remaining the same order magnitude attractive force when the value of coefficient is 0.345. Interestingly, we find that the position of the maximum repulsive force occurs near the critical point. We also investigate the influence of variations in geometrical parameters of the dimer and polarization angle on the force. Finally, the numerical results demonstrate that when the dimer is illuminated by a laser beam, the attractive and repulsive forces can also be achieved. The manipulation of optical force can find potential in optical sorting and transport of NPs.
Polarization-independent pulse retrieval based on frequency resolved optical switching
Authors: Lassonde Philippe , Laramée Antoine , Ibrahim Heide , Cormier Éric , Légaré François , Leblanc Adrien
Published: June 2021

We demonstrate experimentally that the frequency resolved optical switching (FROSt) method is independent of the polarization direction of the pulse to be characterized. In this perspective, it is employed to characterize two or three co-propagating pulses linearly polarized in orthogonal directions, enabling to retrieve simultaneously their temporal intensity and phase profiles together with their group delay. This technique is also applied to track a simple nonlinear process involving different polarization states: type-I second harmonic generation (SHG). We are able to characterize the depleted fundamental pulse along with the generated second-harmonic pulse, thus demonstrating that the FROSt technique is a practical and powerful tool to observe nonlinear processes both in the temporal and spectral domains even if it involves different polarization states.
High-sensitivity fiber-optic X-ray detectors employing gadolinium oxysulfide composites
Authors: Chen Kaifeng , Ren Jiwei , Zhao Chen , Liao Feiyi , Yuan Dengpeng , Lei Lin , Zhao Yiying
Published: June 2021

Radiation detection technologies have been applied in broad fields such as security inspection, medical diagnosis, environment monitoring and scientific analysis. Fiber-optic radiation detectors exhibit unique advantages including miniaturization, resistance to water, remote monitoring, and distributable detection. However, the low sensitivity and the high limit-of-detection limit its practical applications. Herein we demonstrated high-performance fiber-optic X-ray detectors with scintillating composites consisting of UV glue and uniformly distributed gadolinium oxysulfide (GADOX) powders. The impacts of the length, thickness and GADOX weight ratio of the composite coating upon the detector performance, were systematically investigated in terms of the generation and the coupling efficiency of radio-luminescence. Besides the high-performance scintillator, the scattering loss and the geometric factor greatly affected the detector performance. A higher sensitivity and lower limit-of-detection could be achieved by increasing the GADOX weight ratio and decreasing the thickness simultaneously. The optimal detector with the highest GADOX weight ratio (70%), exhibited a linear sensitivity to the X-ray dose rate within 31-1575 µGyair/s, and a low limit-of-detection of ∼0.26 µGyair/s at a tube voltage of 120 kV. The mechanism discussed here will provide insightful guidance for further development of fiber-optic radiation detectors and these promising results demonstrate the potential applications of fiber-optic detectors.
Monolithic integrated waveguide device with dual functions of electro-optic modulation and optical amplification
Authors: Wang Xibin , Zhang Meiling , Jiang Minghui , Lian Tianhang , Wang Fei , Zhang Daming
Published: June 2021

An organic polymer-based monolithic integrated waveguide device with dual functions of electro-optic (EO) modulation and optical amplification is demonstrated. In this Letter, the dual functions are achieved by employing EO polymer as the waveguide upper cladding and organic optical amplified material as the waveguide core layer. Based on this dual-functional waveguide structure, the waveguide amplifier and the EO switch are successfully designed and fabricated on a

S
i
O

2

-Si substrate. An optical gain of 5.8 dB at the wavelength of 1535 nm is obtained in the dual-functional polymer waveguide, and the EO switch based on the dual-functional polymer waveguide also presents a high-speed response time of

∼

10

n
s

.
Spectral causality and the scattering of waves
Authors: Hayran Zeki , Chen Aobo , Monticone Francesco
Published: June 2021

Causality—the principle stating that the output of a system cannot temporally precede the input—is a universal property of nature. Here, we show that analogous input-output relations can also be realized in the spectral domain by leveraging the peculiar properties of time-modulated non-Hermitian photonic systems. Specifically, we uncover the existence of a broad class of complex time-modulated metamaterials that obey the time-domain equivalent of the well-established frequency-domain Kramers–Kronig relations (a direct consequence of causality). We find that, in the scattering response of such time-modulated systems, the output frequencies are inherently prohibited from spectrally preceding the input frequencies, and hence we refer to these systems as “spectrally causal.” We explore the consequences of this newly introduced concept for several relevant applications, including broadband perfect absorption, temporal cloaking of an “event,” and truly unidirectional propagation along a synthetic dimension. By emulating the concept of causality in the spectral domain and providing new tools to extend the field of temporally modulated metamaterials (“chrono-metamaterials”) into the complex realm, our findings may open unexplored opportunities and enable relevant technological advances in various areas of photonics and, more broadly, of wave physics and engineering.
Strukturierte Cloud Transformation in Unternehmen – Veränderungen durch Covid-19?
Authors: Brechlin Fabian
Published: June 2021

Die Verlagerung von On-Premise Infrastruktur und Workflows in die Cloud ist schon lange kein Trend mehr, sondern eine gängige und notwendige Unternehmenspraxis. Die Covid-19 Pandemie hat vielen Unternehmen gezeigt, was für eine zentrale Rolle die Nutzung von Cloud-Services heutzutage spielt. Auch wenn sich die Cloud Transformation an sich durch die Pandemie nicht grundlegend ändert, so wird sie doch vielerorts erheblich beschleunigt oder, falls noch nicht begonnen, angestoßen. Ortsunabhängiges Arbeiten, flexible IT-Strukturen und digitale Kollaborationsmöglichkeiten sind heute oft notwendig, um einen erfolgreichen Betrieb zu gewährleisten. Die Nutzung von Cloud-Services ist dadurch fast unumgänglich geworden.

Dieser Artikel basiert auf zahlreichen Praxiserfahrungen und Beobachtungen aus Cloud-Projekten bei unterschiedlichen Unternehmen. Er zeigt auf, welche Aspekte und Herausforderungen bei einer ganzheitlichen und gut geplanten Cloud Transformation berücksichtigt werden sollten. Dabei wird Bezug auf das Coronavirus als zusätzlicher Cloud-Treiber genommen. Die „Cloud Transformation Roadmap“ als Leitfaden für die Etablierung der Cloud wird vorgestellt, ebenfalls wird auf die Wichtigkeit eines ganzheitlichen Change Managements eingegangen. Es werden konkrete Empfehlungen für eine erfolgreiche Meisterung des Cloud-Einstiegs gegeben.