bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Engineered Carbon Cloth-Based Self-Cleaning Membrane for High-Efficiency Oil–Water Separation
Authors: Chen Nuo , Sun Kexin , Liang Huicong , Xu Bingyan , Wu Si , Zhang Qi , Han Qiang , Yang Jinghai , Lang Jihui
Published: February 2023

A novel engineered carbon cloth (CC)-based self-cleaning membrane containing a Cu:TiO2 and Ag coating has been created via hydrothermal and light deposition methods. The engineered membrane with chrysanthemum morphology has superhydrophilic and underwater superoleophilic performance. The cooperativity strategy of Cu doping and Ag coating to the TiO2 is found to be critical for engineering the separation efficiency and self-cleaning skill of the CC-based membrane under visible light due to the modulated bandgap structure and surface plasmon resonance. The CC-based membrane has excellent oil–water separation performance when Cu is fixed at 2.5 wt% and the Ag coating reaches a certain amount of 0.003 mol/L AgNO3. The contact angle of underwater oil and the separation efficiency are 156° and 99.76%, respectively. Furthermore, the membrane has such an outstanding self-cleaning ability that the above performance can be nearly completely restored after 30 min of visible light irradiation, and the separation efficiency can still reach 99.65% after 100 cycles. Notably, the membrane with exceptional wear resistance and durability can work in various oil–water mixtures and harsh environments, indicating its potential as a new platform of the industrial-level available membrane in dealing with oily wastewater.
Enhancing the Electrochemical Performance of High Voltage LiNi0.5Mn1.5O4 Cathode Materials by Surface Modification with Li1.3Al0.3Ti1.7(PO4)3/C
Authors: Yang Tingting , Chin Chi-Te , Cheng Ching-Hsiang , Zhao Jinsheng
Published: February 2023

A novel method for surface modification of LiNi0.5Mn1.5O4 (LNMO) was proposed, in which a hybrid layer combined by Li1.3Al0.3Ti1.7(PO4)3 (LATP) and carbon (C) composite on LNMO material were connected by lithium iodide. Structure and morphology analyses illustrated that a higher contact area of active substances was achieved by the LATP/C composite layer without changing the original crystal structure of LNMO. XPS analysis proved that I− promoted the reduction of trace Mn4+, resulting in a higher ion conductivity. Galvanostatic charge–discharge tests exhibited the capacity of the LNMO with 5% LATP/C improved with 35.83% at 25 °C and 95.77% at 50 °C, respectively, compared with the bare after 100 cycles, implying the modification of high-temperature deterioration. EIS results demonstrated that one order of magnitude of improvement of the lithium-ion diffusion coefficient of LATP/C-LNMO was achieved (3.04 × 10−11 S cm−1). In conclusion, the effective low-temperature modification strategy improved the ionic and electronic conductivities of the cathode and suppressed the side reactions of high-temperature treatment.
Controllable Patterning of Metallic Photonic Crystals for Waveguide–Plasmon Interaction
Authors: Lin Yuanhai , Che Deqing , Hao Wenjie , Dong Yifei , Guo Heng , Wang Junsheng , Zhang Xinping
Published: February 2023

Waveguide–plasmon polaritons sustained in metallic photonic crystal slabs show fascinating properties, such as narrow bandwidth and ultrafast dynamics crucial for biosensing, light emitting, and ultrafast switching. However, the patterning of metallic photonic crystals using electron beam lithography is challenging in terms of high efficiency, large area coverage, and cost control. This paper describes a controllable patterning technique for the fabrication of an Ag grating structure on an indium–tin oxide (ITO) slab that enables strong photon–plasmon interaction to obtain waveguide–plasmon polaritons. The Ag grating consisting of self-assembled silver nanoparticles (NPs) exhibits polarization-independent properties for the excitation of the hybrid waveguide–plasmon mode. The Ag NP grating can also be annealed at high temperature to form a continuous nanoline grating that supports the hybrid waveguide–plasmon mode only under transverse magnetic (TM) polarization. We tuned the morphology and the periodicity of the Ag grating through the concentration of silver salt and the photoresist template, respectively, to manipulate the strong coupling between the plasmon and the waveguide modes of different orders.
Crystallization and Assembly-Driven Nanostructures for Energy, Electronics, Environment, and Emerging Applications
Authors: Chen Jihua
Published: February 2023

This manuscript has been authored by UT-Battelle, LLC, under Contract No [...]
Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms
Authors: Benito Linconl Agudo Oliveira , Kogawa Evelyn Mikaela , Silva Calliandra Maria de Souza , Melo Fabíola Ferreira , Sales-Peres Silvia Helena de Carvalho , Silva Izabel Cristina Rodrigues da , de Oliveira Karnikowski Margô Gomes
Published: February 2023

(1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. However, several complications were reported, such as vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)D serum levels relate to clinical characteristics, symptoms, or habits in women after their BS, and whether the vitamin D receptor (VDR) gene’s TaqI and FokI polymorphisms affected 25(OH)D levels and the total body bone mineral density (TBBMD). (2) Methods: This cohort cross-sectional comparative analytical prospective study consisted of 27 women, 61.6 ± 5.0 years, submitted to BS one year prior at a public reference hospital, DF-Brazil. All participants were asked to follow the physical and dietary activity recommendations and received vitamin D3 supplements. Their anthropometric, biochemical, and immunological measurements and blood samples were obtained. (3) Results: 73.3% of participants had low 25(OH)D levels, and their levels correlated positively with TBBMD and negatively with systolic pressure. VDR TaqI did not affect 25(OH)D levels, whereas VDR FokI’s allele f presence correlated to a median rise in 25(OH)D levels. Neither polymorphism correlated to TBBMD. (4) Conclusions: 25(OH)D levels were positively correlated with TBBMD, negatively with systolic blood pressure, and were higher in those with the VDR FokI allele f.
Gastric Emptying of New-World Milk Containing A1 and A2 Β-Casein Is More Rapid as Compared to Milk Containing Only A2 Β-Casein in Lactose Maldigesters: A Randomized, Cross-Over Trial Using Magnetic Resonance Imaging
Authors: Ramakrishnan Monica , Zhou Xiaopeng , Dydak Ulrike , Savaiano Dennis A.
Published: February 2023

Lactose maldigesters report an increase in abdominal pain due to the consumption of milk containing a mixture of A1 and A2 β-casein as compared to milk containing only A2 β-casein. Gastric transit affects gastrointestinal symptoms and rapid transit has been associated with an increase in abdominal pain. We conducted a double-blinded, randomized, crossover trial in 10 lactose maldigesters. Subjects consumed each of the two types of milk: conventional milk containing 75% A1 β-casein and 25% A2 β-casein and A2 milk containing 100% A2 β-casein. Magnetic resonance images were acquired, and abdominal pain was rated and recorded at 0, 10, 30, 60 and 120 min after milk consumption. The volume of milk in the stomach was calculated using FSL software. The volume of milk in the stomach after consuming milk with 75% A1 β-casein and 25% A2 β-casein was significantly lower at 30 (p = 0.01), 60 (p = 0.002) and 120 (p < 0.001) minutes as compared to milk with 100% A2 β-casein in the 10 lactose maldigesters. The transit of New-World milk containing A1 and A2 β-casein was more rapid as compared to Old-World milk containing only A2 β-casein. This difference in transit may mediate symptoms of lactose intolerance.
The Effect of Watermelon Juice Supplementation on Heart Rate Variability and Metabolic Response during an Oral Glucose Challenge: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial
Authors: Matthews Rachel , Early Kate S. , Vincellette Cullen M. , Losso Jack , Spielmann Guillaume , Irving Brian A. , Allerton Timothy D.
Published: February 2023

Heart rate variability (HRV) provides a simple method to evaluate autonomic function in health and disease. A reduction in HRV may indicate autonomic dysfunction and is strongly associated with aspects of cardiometabolic disease, including hyperglycemia. Reduced nitric oxide (NO) bioavailability is also implicated in the development of cardiometabolic disease and autonomic dysfunction. Watermelons are natural sources of L-arginine and L-citrulline, substrates used for NO synthesis. Watermelon consumption can improve NO bioavailability. We conducted a randomized, double-blind, placebo-controlled crossover trial to test the effects of 2 weeks of daily watermelon juice (WMJ) supplementation on HRV in response to an oral glucose challenge (OGC) in healthy young adults. We also performed indirect calorimetry to assess if our intervention altered the metabolic response to the OGC. WMJ supplementation preserved high-frequency power (HF) (treatment effect, p = 0.03) and the percentage of successive differences that differ by more than 50 ms (pNN50) (treatment effect, p = 0.009) when compared to the placebo treatment. There was no difference in resting energy expenditure or substate oxidation according to treatment. We report that WMJ supplementation attenuates OGC-induced reductions in HRV. Future work should emphasize the importance of NO bioavailability in autonomic dysfunction in cardiometabolic disease.
Association between Single Nucleotide Polymorphisms Related to Vitamin D Metabolism and the Risk of Developing Asthma
Authors: Rojo-Tolosa Susana , Pineda-Lancheros Laura Elena , Gálvez-Navas José María , Sánchez-Martínez José Antonio , González-Gutiérrez María Victoria , Fernández-Alonso Andrea , Morales-García Concepción , Jiménez-Morales Alberto , Pérez-Ramírez Cristina
Published: February 2023

Asthma is a chronic non-communicable disease that affects all age groups. The main challenge this condition poses is its heterogeneity. The role of vitamin D in asthma has aroused great interest, correlating low vitamin D levels and polymorphisms in the genes involved in its metabolic pathway with the risk of asthma. The aim of this study was to evaluate the influence of 13 single nucleotide polymorphisms (SNPs) related to the vitamin D metabolism on the susceptibility to asthma. An observational case-control study was performed, including 221 patients with asthma and 442 controls of Caucasian origin from southern Spain. The SNPs CYP24A1 (rs6068816, rs4809957), CYP27B1 (rs10877012, rs4646536, rs703842, rs3782130), GC (rs7041), CYP2R1 (rs10741657) and VDR (ApaI, BsmI, FokI, Cdx2, TaqI) were analyzed by real-time PCR, using TaqMan probes. The logistic regression model adjusted for body mass index revealed that in the genotype model, carriers of the Cdx2 rs11568820-AA genotype were associated with a higher risk of developing asthma (p = 0.005; OR = 2.73; 95% CI = 1.36–5.67; AA vs. GG). This association was maintained in the recessive model (p = 0.004). The haplotype analysis revealed an association between the ACTATGG haplotype and higher risk of asthma for the rs1544410, rs7975232, rs731236, rs4646536, rs703842, rs3782130 and rs10877012 genetic polymorphisms (p = 0.039). The other SNPs showed no effect on risk of developing asthma. The Cdx2 polymorphism was significantly associated with the susceptibility of asthma and could substantially act as a predictive biomarker of the disease.
Re-Visiting Antioxidant Therapy in Murine Advanced Atherosclerosis with Brussels Chicory, a Typical Vegetable in Mediterranean Diets
Authors: Li Qing , Du Yushi , Xiang Panyin , Chen Guanyu , Qian Xiaoxian , Li Shuangshuang , Mao Yihui , Ling Wenhua , Wang Dongliang
Published: February 2023

Brussels chicory, a typical vegetable in Mediterranean diets, has been recently reported to stabilize advanced atherosclerotic plaques in the brachiocephalic artery of apoE-deficient (Apoe−/−) mice. Herein, we investigated whether Brussels chicory can stabilize advanced plaques in the aorta via improving oxidative stress. Thirty week old Apoe−/− mice were fed the AIN-93G diet or supplemented with 0.5% freeze-dried Brussels chicory for twenty weeks. Aortic plaque size and stability, aortic relaxation, monocyte adhesion to aortic endothelium, free radicals, and enzymatic and non-enzymatic factors involved in free radical production and elimination in aorta and serum were measured. Brussels chicory consumption did not alter aortic plaque size, however, it stabilized aortic plaques, promoted aortic relaxation, and also inhibited monocyte adhesion to aortic endothelium. Moreover, this administration reduced oxidized LDL (ox-LDL) and 4-hydroxynonenal (4-HNE) content in aortic plaques, associated with inhibited aortic NADPH oxidase (NOX) and uncoupled endothelial nitric oxide synthase (eNOS)-mediated free radical production. However, Brussels chicory consumption did not appreciably alter aortic and serum superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, aortic glutathione (GSH), as well as serum non-enzymatic antioxidants, such as bilirubin, uric acid, and GSH. Collectively, improved oxidative stress might contribute to the atheroprotective effect of Brussels chicory, supporting the prospect of the antioxidant therapy in advanced atherosclerosis progression.
Skin Wound Healing and Anti-Wrinkle-Promoting In Vitro Biological Activities of Caragana sinica Flower Absolute and Its Chemical Composition
Authors: Kim Mi Jung , Won Kyung Jong , Kim Do Yoon , Won Yu Rim , Kim Nan Young , Lee Da Kyoung , Hong Bok Sil , Lee Hwan Myung
Published: February 2023

Caragana sinica (CS; family Legume) was used as a medicinal material to treat neuralgia and arthritis in folk remedies and has been shown to have antioxidant, neuroprotective, and anti-apoptotic effects. However, CS is unknown for its biological activities related to skin. The present study explored the effects of CS flower absolute (CSFAb) on skin repair responses, viz., wound healing and anti-wrinkle-related responses using keratinocytes. CSFAb was extracted using hexane, and its composition was analyzed by GC/MS. The effects of CSFAb on human keratinocytes (HaCaT cells) were evaluated using Boyden chamber, sprouting, water-soluble tetrazolium salt, 5-bromo-2′-deoxyuridine incorporation, ELISA, zymography, and immunoblotting assays. GC/MS detected 46 components in CSFAb. In addition, in HaCaT cells, CSFAb increased the proliferation, migration, and sprout outgrowth and the phosphorylation of ERK1/2, JNK, p38 MAPK, and AKT, and also increased collagen type I and IV synthesis, reduced TNF-α-increased MMP-2 and MMP-9 activities, and upregulated hyaluronic acid (HA) and HA synthase-2 levels. These effects of CSFAb on wound healing and anti-wrinkle-related responses in keratinocytes suggest its potential use for skin repair and care preparations.
Daphnetin Improves Neuropathic Pain by Inhibiting the Expression of Chemokines and Inflammatory Factors in the Spinal Cord and Interfering with Glial Cell Polarization
Authors: Zhang Tianrui , Liang Wulin , Zhang Mingqian , Cui Shuang , Huang Xiyan , Ou Wenjing , Huang Rikang , Gao Jiahui , Jia Zhanhong , Zhang Shuofeng
Published: February 2023

Neuropathic pain (NP) is a common pain disease that seriously affects the quality of life and physical and mental health of patients. Daphnetin is extracted from the Daphne giraldii Nitsche and has the structure of 7,8-dihydroxy coumarin. As a natural product, daphnetin displays a wide range of pharmacological activities, such as analgesia and anti-inflammatory activities, but whether it is able to improve NP through anti-inflammatory effects is unknown. Therefore, this paper intends to investigate the mechanism of daphnetin in improving NP rats affected by the intrathecal injection of tumor necrosis factor-α (TNF-α) from the perspective of anti-inflammation. Our results showed that daphnetin significantly improved hyperalgesia in NP rats. Daphnetin inhibited the activation and polarization of glial cells and neurons in the spinal cord of NP rats and reduced the expression of mRNA and protein of inflammatory factors and chemokine pairs in the spinal cord. Daphnetin inhibited the polarization of human microglia cell 3 (HMC3) cells and human glioma cells (U251) cells toward M1 microglia and A1 astrocytes, respectively, and induced the conversion of M1 microglia and A1 astrocytes to M2 microglia and A2 astrocytes, respectively. In conclusion, daphnetin ameliorates NP by inhibiting the expression of inflammatory factors and chemokines and the polarization of glial cells in the spinal cord of NP rats. This study provides a theoretical basis for the treatment of NP with daphnetin to expand the clinical application of daphnetin.
Recent Advances in the Development of Nanodelivery Systems Targeting the TRAIL Death Receptor Pathway
Authors: Yagolovich Anne V. , Gasparian Marine E. , Dolgikh Dmitry A.
Published: February 2023

The TRAIL (TNF-related apoptosis-inducing ligand) apoptotic pathway is extensively exploited in the development of targeted antitumor therapy due to TRAIL specificity towards its cognate receptors, namely death receptors DR4 and DR5. Although therapies targeting the TRAIL pathway have encountered many obstacles in attempts at clinical implementation for cancer treatment, the unique features of the TRAIL signaling pathway continue to attract the attention of researchers. Special attention is paid to the design of novel nanoscaled delivery systems, primarily aimed at increasing the valency of the ligand for improved death receptor clustering that enhances apoptotic signaling. Optionally, complex nanoformulations can allow the encapsulation of several therapeutic molecules for a combined synergistic effect, for example, chemotherapeutic agents or photosensitizers. Scaffolds for the developed nanodelivery systems are fabricated by a wide range of conventional clinically approved materials and innovative ones, including metals, carbon, lipids, polymers, nanogels, protein nanocages, virus-based nanoparticles, dendrimers, DNA origami nanostructures, and their complex combinations. Most nanotherapeutics targeting the TRAIL pathway are aimed at tumor therapy and theranostics. However, given the wide spectrum of action of TRAIL due to its natural role in immune system homeostasis, other therapeutic areas are also involved, such as liver fibrosis, rheumatoid arthritis, Alzheimer’s disease, and inflammatory diseases caused by bacterial infections. This review summarizes the recent innovative developments in the design of nanodelivery systems modified with TRAIL pathway-targeting ligands.
Intravital Microscopy Reveals Endothelial Transcytosis Contributing to Significant Tumor Accumulation of Albumin Nanoparticles
Authors: Wei Guoguang , Zhang Sihang , Yu Sheng , Lu Wei
Published: February 2023

The principle of enhanced permeability and retention (EPR) effect has been used to design anti-cancer nanomedicines over decades. However, it is being challenged due to the poor clinical outcome of nanoparticles and controversial physiological foundation. Herein, we use a near-infrared-II (1000–1700 nm, NIR-II) fluorescence probe BPBBT to investigate the pathway for the entry of human serum albumin-bound nanoparticles (BPBBT-HSA NPs) into tumor compared with BPBBT micelles with phospholipid-poly (ethylene glycol) of the similar particle size about 110 nm. The plasma elimination half-life of BPBBT micelles was 2.8-fold of that of BPBBT-HSA NPs. However, the area under the BPBBT concentration in tumor-time curve to 48 h post-injection (AUCtumor0→48h) of BPBBT-HSA NPs was 7.2-fold of that of BPBBT micelles. The intravital NIR-II fluorescence microscopy revealed that BPBBT-HSA NPs but not BPBBT micelles were transported from the tumor vasculature into tumor parenchyma with high efficiency, and endocytosed by the tumor cells within 3 h post-injection in vivo. This effect was blocked by cross-linking BPBBT-HSA NPs to denature HSA, resulting in the AUCtumor0→48h decreased to 22% of that of BPBBT-HSA NPs. Our results demonstrated that the active process of endothelial transcytosis is the dominant pathway for albumin-bound nanoparticles’ entry into tumor.
Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists
Authors: Mousavifar Leila , Sarshar Meysam , Bridot Clarisse , Scribano Daniela , Ambrosi Cecilia , Palamara Anna Teresa , Vergoten Gérard , Roubinet Benoît , Landemarre Ludovic , Bouckaert Julie , Roy René
Published: February 2023

Selective antiadhesion antagonists of Uropathogenic Escherichia coli (UPEC) type-1 Fimbrial adhesin (FimH) are attractive alternatives for antibiotic therapies and prophylaxes against acute or recurrent urinary tract infections (UTIs) caused by UPECs. A rational small library of FimH antagonists based on previously described C-linked allyl α-D-mannopyranoside was synthesized using Heck cross-coupling reaction using a series of iodoaryl derivatives. This work reports two new members of FimH antagonist amongst the above family with sub nanomolar affinity. The resulting hydrophobic aglycones, including constrained alkene and aryl groups, were designed to provide additional favorable binding interactions with the so-called FimH “tyrosine gate”. The newly synthesized C-linked glycomimetic antagonists, having a hydrolytically stable anomeric linkage, exhibited improved binding when compared to previously published analogs, as demonstrated by affinity measurement through interactions by FimH lectin. The crystal structure of FimH co-crystallized with one of the nanomolar antagonists revealed the binding mode of this inhibitor into the active site of the tyrosine gate. In addition, selected mannopyranoside constructs neither affected bacterial growth or cell viability nor interfered with antibiotic activity. C-linked mannoside antagonists were effective in decreasing bacterial adhesion to human bladder epithelial cells (HTB-9). Therefore, these molecules constituted additional therapeutic candidates’ worth further development in the search for potent anti-adhesive drugs against infections caused by UPEC.
Synthesis and Characterization of Hierarchical Zeolites Modified with Polysaccharides and Its Potential Role as a Platform for Drug Delivery
Authors: Wawrzyńczak Agata , Nowak Izabela , Woźniak Natalia , Chudzińska Jagoda , Feliczak-Guzik Agnieszka
Published: February 2023

Hierarchical zeolites are aluminosilicates with a crystal structure, which next to the micropores possess secondary porosity in the range of mesopores and/or small macropores. Due to their ordered structure and additional secondary porosity, they have aroused great interest among scientists in recent years. Therefore, the present work concerns the synthesis and characterization of hierarchical zeolites with secondary mesoporosity, based on commercial zeolites such as MFI (ZSM-5), BEA (β) and FAU (Y), and modified with polysaccharides such as inulin, hyaluronic acid, and heparin. All materials were characterized by various analytical techniques and applied as a platform for delivery of selected drug molecules. On the basis of X-ray diffraction (presence of reflections in the 2θ angle range of 1.5–2.5°) and low-temperature nitrogen sorption isotherms (mixture of isotherms of I and IV type) additional secondary porosity was found in the mesopore range. Additional tests were also conducted to determine the possibility of loading selected molecules with biological activity into the aforementioned materials and then releasing them in the therapeutic process. Molecules with different therapeutic options were selected for testing, namely ibuprofen, curcumin, and ferulic acid with anti-inflammatory, potentially anticancer, antioxidant, and skin discoloration activities, respectively. Preliminary studies have confirmed the possibility of using hierarchical zeolites as potential carriers for bioactive molecules, as the loading percentage of active substances ranged from 39–79% and cumulative release for ibuprofen reached almost 100% after 8 h of testing.
Cellulose-Based Scaffolds: A Comparative Study for Potential Application in Articular Cartilage
Authors: Cordeiro Rachel , Alvites Rui D. , Sousa Ana C. , Lopes Bruna , Sousa Patrícia , Maurício Ana C. , Alves Nuno , Moura Carla
Published: February 2023

Osteoarthritis is a highly prevalent disease worldwide that leads to cartilage loss. Tissue engineering, involving scaffolds, cells, and stimuli, has shown to be a promising strategy for its repair. Thus, this study aims to manufacture and characterise different scaffolds with poly(ε-caprolactone) (PCL) with commercial cellulose (microcrystalline (McC) and methyl cellulose (MC) or cellulose from agro-industrial residues (corncob (CcC)) and at different percentages, 1%, 2%, and 3%. PCL scaffolds were used as a control. Morphologically, the produced scaffolds presented porosities within the desired for cell incorporation (57% to 65%). When submitted to mechanical tests, the incorporation of cellulose affects the compression resistance of the majority of scaffolds. Regarding tensile strength, McC2% showed the highest values. It was proven that all manufactured scaffolds suffered degradation after 7 days of testing because of enzymatic reactions. This degradation may be due to the dissolution of PCL in the organic solvent. Biological tests revealed that PCL, CcC1%, and McC3% are the best materials to combine with human dental pulp stem/stromal cells. Overall, results suggest that cellulose incorporation in PCL scaffolds promotes cellular adhesion/proliferation. Methyl cellulose scaffolds demonstrated some advantageous compressive properties (closer to native cartilaginous tissue) to proceed to further studies for application in cartilage repair.
Functional Properties of Nonwovens as an Insulating Layer for Protective Gloves
Authors: Šajn Gorjanc Dunja
Published: February 2023

The basic intention of the present work is to analyze the influence of the incorporated microporous membrane and the technology of the needling process on the functional properties of nonwovens designed as an insulating layer for protective gloves for protection against high temperatures. The investigated nonwovens are produced in carded nonwoven formation and mechanically bonded with needle bonding. The studied nonwovens contain a microporous membrane of polyester (PES) with a thickness of 20 µm (samples marked as ST and STL). In the theoretical part of the research work, the nonwovens and some technology stages are presented. The experimental part of the present work deals with the mechanical properties: breaking stress and strain, viscoelastic properties (yield strength, elastic modulus) and elastic recovery after cyclic loading and thermal conduction. In the experimental part, permeability properties (water vapor permeability, air permeability) are also analyzed. The results of the investigation show that the samples marked as ST and STL, which contain a microporous PES membrane, have a higher breaking stress than the samples marked as T and TL without the microporous PES membrane. Samples marked as ST and STL also exhibit higher values of elongation at break and limit of recoverable deformation (stress and strain at yield) and a lower modulus of elasticity than samples marked as T and TL. The samples marked as ST and STL are mechanically bonded to the lamellar plate using forked needles and therefore have a textured (ribbed) shape that affects the improved mechanical properties. The TL and STL samples, which contain a microporous PES membrane, have higher elastic recovery and lower air permeability than the T and TL samples, while water vapor permeability is lower only for the ST sample.
Brownian Motion in Optical Tweezers, a Comparison between MD Simulations and Experimental Data in the Ballistic Regime
Authors: Zembrzycki Krzysztof , Pawłowska Sylwia , Pierini Filippo , Kowalewski Tomasz Aleksander
Published: February 2023

The four most popular water models in molecular dynamics were studied in large-scale simulations of Brownian motion of colloidal particles in optical tweezers and then compared with experimental measurements in the same time scale. We present the most direct comparison of colloidal polystyrene particle diffusion in molecular dynamics simulations and experimental data on the same time scales in the ballistic regime. The four most popular water models, all of which take into account electrostatic interactions, are tested and compared based on yielded results and resources required. Three different conditions were simulated: a freely moving particle and one in a potential force field with two different strengths based on 1 pN/nm and 10 pN/nm. In all cases, the diameter of the colloidal particle was 50 nm. The acquired data were compared with experimental measurements performed using optical tweezers with position capture rates as high as 125 MHz. The experiments were performed in pure water on polystyrene particles with a 1 μm diameter in special microchannel cells.
Effect of the Interface/Interphase on the Water Ingress Properties of Joints with PBT-GF30 and Aluminum Substrates Using Silicone Adhesive
Authors: Borges Catarina S. P. , Marques Eduardo A. S. , Carbas Ricardo J. C. , Akhavan-Safar Alireza , Ueffing Christoph , Weißgraeber Philipp , da Silva Lucas F. M.
Published: February 2023

The aim of this work is to analyze the difference between silicone/composite and silicone/metal interphases, both in terms of water diffusion behavior and failure of the aged joints. For that, silicone joints with two different suhbstrates were prepared. The substrates were polybutylene terephthalate with 30% of short glass fiber (PBT-GF30) and 6082-T6 aluminum. It is assumed that the water uptake of the joints is equal to the water uptake of the substrate, adhesive, and interphase. Therefore, knowing the first three, the last could be isolated. To study the water diffusion behavior of the complete joint, rectangular joints were prepared, immersed in water and their water uptake was measured. The water immersion was conducted at 70 °C. It was concluded that the aluminum/silicone joints absorbed more water through the interphase region than the PBT-GF30/silicone joints, since the difference between the expected water uptake and the experimentally measured mass gain is significantly higher, causing adhesive failure of the joint. The same was not observed in the PBT-GF30/silicone, with a more stable interphase, that does not absorb measurable quantities of water and always exhibits cohesive failure.
The Role of Drying Schedule and Conditioning in Moisture Uniformity in Wood: A Machine Learning Approach
Authors: Rahimi Sohrab , Nasir Vahid , Avramidis Stavros , Sassani Farrokh
Published: February 2023

Monitoring the moisture content (MC) of wood and avoiding large MC variation is a crucial task as a large moisture spread after drying significantly devalues the product, especially in species with high green MC spread. Therefore, this research aims to optimize kiln-drying and provides a predictive approach to estimate and classify target timber moisture, using a gradient-boosting machine learning model. Inputs include three wood attributes (initial moisture, initial weight, and basic density) and three drying parameters (schedule, conditioning, and post-storage). Results show that initial weight has the highest correlation with the final moisture and possesses the highest relative importance in both predictive and classifier models. This model demonstrated a drop in training accuracy after removing schedule, conditioning, and post-storage from inputs, emphasizing that the drying parameters are significant in the robustness of the model. However, the regression-based model failed to satisfactorily predict the moisture after kiln-drying. In contrast, the classifying model is capable of classifying dried wood into acceptable, over-, and under-dried groups, which could apply to timber pre- and post-sorting. Overall, the gradient-boosting model successfully classified the moisture in kiln-dried western hemlock timber.
Effect of Annealing Process and Molecular Weight on the Polymorphic Transformation from Form II to Form I of Poly(1-butene)
Authors: Zhang Zhenkang , Xue Yanhu , Li Rui , Liu Wei , Liu Peng , Ji Xiangling
Published: February 2023

Poly(1-butene) (PB-1) resin has excellent mechanical properties, outstanding creep resistance, environmental stress crack resistance and other excellent properties. However, PB-1 resin experiences a crystal transformation for a period, which seriously affects the production efficiency and directly restricts its large-scale commercial production and application. The factors affecting the crystal transformation of PB-1 are mainly divided into external and internal factors. External factors include crystallization temperature, thermal history, nucleating agent, pressure, solvent induction, etc., and internal factors include chain length, copolymerization composition, isotacticity, its distribution, etc. In this study, to avoid the interference of molecular weight distribution on crystallization behavior, five PB-1 samples with narrow molecular weight distribution (between 1.09 and 1.44) and different molecular weights (from 23 to 710 k) were chosen to research the influence of temperature and time in the step-by-step annealing process and molecular weight on the crystal transformation by differential scanning calorimetry (DSC). When the total annealing time was the same, the step-by-step annealing process can significantly accelerate the rate of transformation from crystal form II to I. PB-1 samples with different molecular weights have the same dependence on annealing temperature, and the optimal nucleation temperature (i.e., low annealing temperature, Tl) and growth temperature (i.e., high annealing temperature, Th) were −10 °C and 40 °C, respectively. At these two temperatures, the crystal form I obtained by step-by-step annealing had the highest content; other lower or higher annealing temperatures would reduce the rate of crystal transformation. When the annealing temperature was the same, crystal form I first increased with annealing time tl, then gradually reached a plateau, but the time to reach a plateau was different. The crystalline form I contents of the samples with lower molecular weight increased linearly with annealing time th. However, the crystalline form I contents of the samples with higher molecular weight increased rapidly with annealing time th at the beginning, and then transformation speed from form II to form I slowed down, which implied that controlling Tl/tl and Th/th can tune the different contents of form I and form II. At the same Tl/tl or Th/th, with increasing molecular weight, the transformation speed from form II to form I via the step-by-step annealing process firstly increased and then slowed down due to the competition of the number of linked molecules and molecular chain mobility during crystallization. This study definitely provides an effective method for accelerating the transformation of poly(1-butene) crystal form, which not only has important academic significance, but also has vital industrial application.
The Effect of the Poly-Articulated Prosthetic Hand on Shoulder and Trunk Compensatory Movements during Manipulation and Grasp Tasks
Authors: Cutti Andrea Giovanni , Morosato Federico , Gruppioni Emanuele , Teti Gregorio , De Michieli Lorenzo , Gentile Cosimo
Published: February 2023

Conventional myoelectric prosthetic hands only offer a basic tri-digital pinch. Transradial amputees need to compensate for this lack of function with altered kinematics at the shoulder and trunk that might expose them to an increased risk of musculoskeletal injuries. A poly-articulated prosthetic hand may reduce the physical compensatory movements and close the gap between the sound and the prosthetic side. Six male transradial amputees completed four standardized reach-and-grasp activities with their tri-digital, poly-articulated and sound side hands. Trunk, shoulder girdle, scapula and humerus kinematics were measured with an optoelectronic system. Differences between hands were analyzed in terms of the amplitude of motion, the duration of the altered kinematics over the motion cycle, peak-to-peak amplitude and time to complete the activity. An overall score was defined, which assigned three points when the kinematics of a joint angle was altered for over 41% of the motion cycle, two points between 11 ÷ 40% and one point between 1 ÷ 10%; thus, a lower score indicates less variation from normal kinematics. Despite no changes in times, tri-digital vs. sound hand scored 93 points, tri-digital vs. poly-articulated hands scored 49 and poly-articulated vs. sound hand scored 28, supporting the hypotheses of the poly-articulated hand positively affects shoulder and trunk kinematics.
Biophysical Dissection of Isolated GPCRs: The Adenosine A2A Receptor under the Bistouries
Authors: Banères Jean-Louis , Botzanowski Thomas , Boutin Jean A. , Calamini Barbara , Castel Jérôme , Catoire Laurent J. , Cianférani Sarah , Demesmay Claire , Ferguson Gavin , Ferry Gilles , Kniazeff Julie , Krimm Isabelle , Langer Thierry , Lebon Guillaume , Ley Marie , Nyerges Miklos , Schwob Magali , Venien-Bryan Catherine , Wagner Renaud , Zeder-Lutz Gabrielle , Zilian-Stohrer Claudia
Published: February 2023

In an effort to provide an overview of the biophysical approaches used to study G-protein-coupled receptors, we chose to consider the adenosine A2A receptor as a model, as it is widely reported in the literature to explore the way GPCRs are studied nowadays. After a brief introduction of the receptor, we gathered descriptions of the various tools used to investigate the pharmacology and structure of the A2A receptor. We began by describing the key developments which have led to successful studies of GPCRs including the cloning, expression and purification of A2A, and the subsequent characterizations including quality control, binding and functional studies that have been necessary for the further understanding of the receptor. Then, we reviewed the reconstitution of A2A into nanodiscs as well as the use of this biological material in structural mass spectrometry, NMR, calorimetry and various other approaches to gain not only information about the structure and function of A2A, but also the dynamics of the receptor and the tools necessary to pursue such investigations. The body of techniques presented herein are applicable to all GPCRs amenable to purification.
Highlighting the Role of Archaea in Urban Mine Waste Exploitation and Valorisation
Authors: Abdel Azim Annalisa , Bellini Ruggero , Vizzarro Arianna , Bassani Ilaria , Pirri Candido Fabrizio , Menin Barbara
Published: February 2023

E-materials become e-waste once they have been discarded without the intent of reuse. Due to its rich content of metals, among which many are Critical Raw Materials (CRMs), e-waste can be considered an urban mine to exploit and valorise. Common metal refining is performed by energy-intensive processes frequently based on the use of fossil fuel. Bio-metallurgy is a promising alternative for e-waste valorisation based on biological routes of specialised microorganisms able to leach solid-containing metals. Because of the physiology of these microorganisms, microbial leaching can be economically feasible, besides being an environmentally sustainable process. Like Bacteria and Fungi, Archaea are also capable of metal leaching activity, though their potential is underestimated. Among them, the extremophiles are the most studied and applied in the field of metal recovery, while mesophilic species are less common but still of high interest. Here we provide the state of industrial application of bio-metallurgy and report on the state of the art of Archaea exploitation in metal recovery from e-waste. Moreover, we give a special highlight to methanogenic archaea, which are able to convert CO2 into methane in order to highlight the potential for the valorisation of CO2-rich industrial streams generated by key processes (i.e., anaerobic digestion, concrete, and steel production) in CH4 for gas grid distribution, while making metals content in e-waste available again as raw material.
Singapore’s Secularism and Its Pragmatic Approach to Religion
Authors: Musa Mohammad Alami
Published: February 2023

Singapore embraces a form of secularism that provides the state with the authority to unilaterally decide on where to draw the lines between religion, politics, and state. This paper presents examples that dominate Singapore’s approach to religion and governance. Given the centrality of religion in the lives of Singaporeans, this article highlights how the state does not cast aside the social significance of religion but remains engaged with it. The model of secularism in Singapore affords the state the flexibility to easily switch between two broad types of secularism, namely a ‘soft secularism’, a religion-friendly variety, and a ‘hard secularism’, which the state employs as a tool for political control and management of society as it wrestles with existential challenges to ensure its continued survival.
Machine Learning of Usable Area of Gable-Roof Residential Buildings Based on Topographic Data
Authors: Dawid Leszek , Cybiński Kacper , Stręk Żanna
Published: February 2023

In real estate appraisal, especially of residential buildings, one of the primary evaluation parameters is the property’s usable area. When determining the property price, Polish appraisers use data from comparable transactions included in the Real Estate Price Register (REPR), which is highly incomplete, especially regarding properties’ usable areas. This incompleteness renders the identification of comparable transactions challenging and may lead to incorrect prediction of the property price. We address this challenge by applying machine learning methods to estimate the usable area of buildings with gable roofs based only on their topographic data, which is widely available in Poland in the Database of Topographic Objects (BDOT10k) of Light Detection and Ranging (LiDAR) origin. We show that three features are enough to make accurate predictions of the usable area: the covered area, the building’s height, and the number of stories optionally. A neural network trained on buildings from architectural bureaus reached a 4% median percentage error on the same source and 15% on the real buildings from the city of Koszalin, Poland. Therefore, the proposed method can be applied by appraisers to estimate the usable area of buildings with known transaction prices and solve the problem of finding comparable properties for appraisal.
Design and Application of a UAV Autonomous Inspection System for High-Voltage Power Transmission Lines
Authors: Li Ziran , Zhang Yanwen , Wu Hao , Suzuki Satoshi , Namiki Akio , Wang Wei
Published: February 2023

As the scale of the power grid continues to expand, the human-based inspection method struggles to meet the needs of efficient grid operation and maintenance. Currently, the existing UAV inspection system in the market generally has short endurance power time, high flight operation requirements, low degree of autonomous flight, low accuracy of intelligent identification, slow generation of inspection reports, and other problems. In view of these shortcomings, this paper designs an intelligent inspection system based on self-developed UAVs, including autonomous planning of inspection paths, sliding film control algorithms, mobile inspection schemes and intelligent fault diagnosis. In the first stage, basic data such as latitude, longitude, altitude, and the length of the cross-arms are obtained from the cloud database of the power grid, while the lateral displacement and vertical displacement during the inspection drone operation are calculated, and the inspection flight path is generated independently according to the inspection type. In the second stage, in order to make the UAV’s flight more stable, the reference-model-based sliding mode control algorithm is introduced to improve the control performance. Meanwhile, during flight, the intelligent UAV uploads the captured photos to the cloud in real time. In the third stage, a mobile inspection program is designed in order to improve the inspection efficiency. The transfer of equipment is realized in the process of UAV inspection. Finally, to improve the detection accuracy, a high-precision object detector is designed based on the YOLOX network model, and the improved model increased the mAP0.5:0.95 metric by 2.22 percentage points compared to the original YOLOX_m for bird’s nest detection. After a large number of flight verifications, the inspection system designed in this paper greatly improves the efficiency of power inspection, shortens the inspection cycle, reduces the investment cost of inspection manpower and material resources, and successfully fuses the object detection algorithm in the field of high-voltage power transmission lines inspection.
Spatiotemporal Distribution and Main Influencing Factors of Grasshopper Potential Habitats in Two Steppe Types of Inner Mongolia, China
Authors: Guo Jing , Lu Longhui , Dong Yingying , Huang Wenjiang , Zhang Bing , Du Bobo , Ding Chao , Ye Huichun , Wang Kun , Huang Yanru , Hao Zhuoqing , Zhao Mingxian , Wang Ning
Published: February 2023

Grasshoppers can greatly interfere with agriculture and husbandry, and they will breed and grow rapidly in suitable habitats. Therefore, it is necessary to extract the distribution of the grasshopper potential habitat (GPH), analyze the spatial-temporal characteristics of the GPH, and detect the different effects of key environmental factors in the meadow and typical steppe. To achieve the goal, this study took the two steppe types of Xilingol (the Inner Mongolia Autonomous Region of China) as the research object and coupled them with the MaxEnt and multisource remote sensing data to establish a model. First, the environmental factors, including meteorological, vegetation, topographic, and soil factors, that affect the developmental stages of grasshoppers were obtained. Secondly, the GPH associated with meadow and typical steppes from 2018 to 2022 were extracted based on the MaxEnt model. Then, the spatial-temporal characteristics of the GPHs were analyzed. Finally, the effects of the habitat factors in two steppe types were explored. The results demonstrated that the most suitable and moderately suitable areas were distributed mainly in the southern part of the meadow steppe and the eastern and southern parts of the typical steppe. Additionally, most areas in the town of Gaorihan, Honggeergaole, Jirengaole, as well as the border of Wulanhalage and Haoretugaole became more suitable for grasshoppers from 2018 to 2022. This paper also found that the soil temperature in the egg stage, the vegetation type, the soil type, and the precipitation amount in the nymph stage were significant factors both in the meadow and typical steppes. The slope and precipitation in the egg stage played more important roles in the typical steppe, whereas the aspect had a greater contribution to the meadow steppe. These findings can provide a methodical guide for grasshopper control and management and for further ensuring the security of agriculture and husbandry.