bluuebunny/crossref_metadata_2025 huggingface dataset:
The concurrent docking of diphenoquinone and cholesterol to the human ATP-binding cassette A1
Authors: Tsujita Maki , de Silva Leticia Alves , Nakasuka Kosuke , Yamamoto Junki , Ford Robert C , Stockner Thomas
Published: September 2024

Aim: Spiroquinone (SQ) and 3,3',5,5'-tetra-tert-butyldiphenoquinone (DQ), metabolites of the probucol, promote ABCA1-mediated HDL neogenesis. To further investigate the detailed mechanism, we analyzed the docking pose of these drugs to ABCA1 using GOLD (Genetic Optimization for Ligand Docking) software, an in silico structural analysis application. Then, docking ability of cholesterol to the drug-ABCA1 complex were investigated.
Methods: The ligand-bound ABCG2 (PDB:6ETI) was used for ligand redocking to select the optimal scoring function of GOLD. Next, human ABCA1 (PDB:5XJY) was used and the docking poses of probucol, SQ, DQ, and MDL-29311 were examined using the selected scoring function. Furthermore, binding poses of cholesterol and POPC to the drug-docked ABCA1 complex were evaluated.
Results: The ChemScore function was the most accurate predictor of the original docking site of the ligand to ABCG2. Using this function to predict the docking calculations for ABCA1, optimal docking poses was obtained at the transmembrane region. Furthermore, docking poses for cholesterol were predicted into ABCA1 bound to DQ and to MDL-29311(fitness score; 41.42 and 41.61, respectively) while no docking poses in probucol- or SQ-bound ABCA1 were obtained.
Discussion:We reported that DQ, an accelerator of the preb-HDL generation, stabilizes ABCA1 and sustains HDL neogenesis(1). In the current study, in addition to DQ docking pose, docking sites of cholesterol and POPC were observed in ABCA1 in silico. Furthermore, probucol, which inhibits ABCA1-mediated preb-HDL neogenesis, showed no additional docking sites for cholesterol or POPC.
Conclusion: These results are the first to elucidate the at atomic level of the mechanism in lipid transport action of probucol and its metabolite, DQ, on ABCA1. Future clinical applications of DQ for targeting the increased plasma HDL and regression of atherosclerotic plaques are expected.
Medium-Scale Expensive Optimization Framework with Weighted Committee- Based Surrogate-Assisted Differential Evolution: Application to Enhanced Geothermal Systems
Authors: Ren Xiaoqing , Wang Hongliang , Hu Hanyu , Wang Jian , Ablameyko Sergey V.
Published: September 2024

Real-world optimization challenges frequently involve computationally expensive evaluations, necessitating efficient optimization strategies. To address the demands of medium-scale expensive optimization problems, this research introduces and explores a novel Weighted Committee-Based Surrogate-Assisted Differential Evolution Framework (WCBDEF). This framework innovatively combines principles from active learning and ensemble learning, iteratively interrogating the most ambiguous and high-fidelity solutions to ensure judicious allocation of evaluation resources. WCBDEF employs a dual sampling criterion, with offline optimization dedicated to exploration and online optimization focused on exploitation. Benchmarking against state-of-the-art surrogate algorithms across six test functions reveals that WCBDEF demonstrates a clear advantage in performance, confirming its efficacy in tackling the challenges of expensive optimization. Moreover, its application in optimizing operational parameters for two Enhanced Geothermal Systems (EGS) models has resulted in a significant reduction in the Levelized Cost of Electricity (LCOE), surpassing existing algorithmic solutions. The results demonstrate that WCBDEF significantly outperforms existing methods, exhibiting superior performance over single surrogate-assisted evolutionary algorithms (SAEAs) on real-world problems, thereby showcasing its exceptional potential for solving expensive optimization problems.
Vom Homo organisans zum Homo digitalis
Authors: Wendt Thomas
Published: September 2024

Der Beitrag setzt Positionen der Anthropologie und die technisch-mediale Formatierung des Subjekts durch Organisation für die theoriesystematische Analyse der fortschreitenden Digitalisierung in Beziehung. Um die gesellschaftliche Stellung des Menschen vor dem Hintergrund der Ubiquität organisationaler Strukturzusammenhänge zu reflektieren, wird eine Anthropologie der Organisation als Medium entworfen. Der Homo organisans ist das Ergebnis des organisationalen Umgangs mit den Motiven und Idiosynkrasien des Subjekts und der planerischen Systematisierung seiner Wahrnehmungs- und Handlungsmöglichkeiten. Die Mediengeschichte der Organisation zeigt einerseits, dass anthropologische Annahmen als Ausgangspunkte der technisch-medialen Formatierung des Subjekts fungieren. Zum anderen wird deutlich, dass der Digitalisierung der Weg bereitet wird, indem Organisationen mediale Formen datengetriebener Steuerung zum eigenen Strukturaufbau nutzen. Aktuell verändert die digitale Transformation der sozialen Form der Organisation die Möglichkeits- und Wirklichkeitsbedingungen des Homo organisans: Digitale Organisation erzeugt den Homo digitalis. Vor dem Hintergrund immer besser gelingender digitaler Strukturbildungsprozesse und dem damit verbundenen Einfluss verweist der Beitrag auf die gegenwärtige Relevanz der Anthropologie für die Frage nach den Wirklichkeits- und Möglichkeitsbedingungen menschlichen Soseins in der digitalen Moderne.
The Russian Arctic in the international economic and geopolitical agenda
Authors: Fadeev A. M.
Published: September 2024

The article considers the key economic and geopolitical aspects in the activities of states having strategic interests in the Arctic region. Attention is paid to potential challenges that Russia may face in terms of international cooperation, including militarization. The current development of the Northern Sea Route with the assessment of its integration prospects into the global logistics network is considered. The state of the infrastructure in the Arctic is evaluated, along with identification of possible development directions.
Development of improved technologies for protecting fish from infections in aquaculture
Authors: Dong Xiangli , Shilin M. B. , Leonteva E. O.
Published: September 2024

The current intensification of marine aquaculture is inevitably associated with such environmental issues as growing infections and the need to apply antibiotic and other antimicrobial preparations. This leads to antibiotic pollution in the environment. Latest technologies aimed at preventing fish infections in aquaculture are based on the vaccination of the objects under cultivation. These technologies allow the use of antibiotics to be reduced and the balance of the microbial environment in aquaculture to be restored, eventually minimizing the negative effects of antibiotic residues on the human health. In this work, we set out to study molecular mechanisms underlying the immune response of fish to viral infections. Data on the expression of some genes of the most important aquaculture objects in Russia and China in response to infection and during its progression was obtained. The research results can be used when developing vaccines against vibriosis with the purpose of minimizing the application of medical preparations, such as antibiotics. These measures are important for maintaining healthy fish habitats and, as a consequence, the human health.
Development of tourism in the mining areas of Scandinavia and Murmansk region
Authors: Huber M. , Iakovleva O. A. , Zhigunova G. V.
Published: September 2024

In this article, we set out to assess opportunities for the development of tourism in mining regions in the Scandinavian and Kola Peninsulas, as well as to identify threats arising from these activities in comparison with known examples. It is assumed that the Arctic zone can become a promising place for the development of tourism and urbanization in the future.
Higher-form symmetry and chiral transport in real-time Abelian lattice gauge theory
Authors: Das Arpit , Florio Adrien , Iqbal Nabil , Poovuttikul Napat
Published: September 2024

We study classical lattice simulations of theories of electrodynamics coupled to charged matter at finite temperature, interpreting them using the higher-form symmetry formulation of magnetohydrodynamics (MHD). We compute transport coefficients using classical Kubo formulas on the lattice and show that the properties of the simulated plasma are in complete agreement with the predictions from effective field theories. In particular, the higher-form formulation allows us to understand from hydrodynamic considerations the relaxation rate of axial charge in the chiral plasma observed in previous simulations. A key point is that the resistivity of the plasma – defined in terms of Kubo formulas for the electric field in the 1-form formulation of MHD – remains a well-defined and predictive quantity at strong electromagnetic coupling. However, the Kubo formulas used to define the conventional conductivity vanish at low frequencies due to electrodynamic fluctuations, and thus the concept of the conductivity of a gauged electric current must be interpreted with care.
Unveiling investor behavior: An investigation into India’s pharmaceutical sector during COVID-19
Authors: Lobo Sonia , Bhat Sudhindra
Published: September 2024

This study examines the factors influencing retail investors’ decision to invest into the Indian pharmaceutical sector amidst the COVID-19 global health crisis. Confronting the obstacles introduced by the pandemic has helped create a robust foundation for the Indian pharma sector to grow rapidly in the future. As the industry demonstrated signs of considerable future growth, investors favored pharmaceutical investments during COVID-19. Retail investors were mainly the ones who went on a shopping spree during the pandemic. This backdrop provides a unique context to explore the retail investors’ behavior in the Indian pharmaceutical landscape. Leveraging the Theory of Planned Behavior (TPB), this study marks the first attempt to introduce behavior toward market fundamentals as a mediating factor into the TPB framework. To conduct the study, data were collected from 305 retail investors located in Karnataka’s South Canara region, who invested into the Indian pharmaceutical industry during the pandemic, using snowball sampling. The e-survey was employed for data collection. The results reveal that attitudes toward pharmaceutical investments, subjective norms, Perceived Behavioral Control (PBC), and behavior toward market fundamentals have significantly influenced investor decisions. Notably, behavior toward market fundamentals has partially mediated the relationship between attitude toward pharma investment and investment decision and PBC and investment decision. However, the mediation effect of behavior toward market fundamentals was not evident between the subject norm and the investment decision. The study holds pivotal implications for policymakers, government bodies, and industry stakeholders to promote pharmaceutical investments.
Assessment of water quality in the Great Zab River (Erbil city, Iraq) exposed to wastewater from different industries using the WQI and GIS-based Python script approaches
Authors: Dilekoğlu Mehmet Fatih , Abdulhaq Harem Ali , Hussein Masoud Hamad
Published: September 2024

This study was conducted to assess the water quality of the Great Zab River (GZR) under potential pollutant pressure from some industries. The Water Quality Index (WQI) was used to evaluate the results of the water quality monitoring study. WQI and Geographical Information System (GIS)-based Python scripts were used to evaluate the results. Results indicate varying water qualities, ranging from moderate to poor, with fluctuations attributed to pollution from industrial plants mixing with river water. The WQI rating of the GZR before industrial discharges was 57.48, and in the lower part, after discharges, the WQI rating was 56.00, indicating marginal water quality. In contrast, the areas near the Cola Factory, where the river confluence occurs, have WQI values of 43.32 and 44.97, representing unacceptable, poor water quality. The study highlights that the refinery, Cola factory, and power plant locations significantly impact the river's water quality. These findings underscore the urgent need to adopt ecological practices, establish environmental regulations, and implement sustainable technologies to preserve the river's natural state. Concise measures aimed at eliminating pollutant sources and enhancing environmental awareness within communities are essential for the conservation of the GZR and the the protection of its surrounding ecosystems. surrounding ecosystems.
Exploring Hepatocellular Carcinoma Pathogenesis: The Influence of Genetic Polymorphisms
Authors: Mollazadeh Samaneh , Saeedi Nikoo , Al-Asady Abdulridha Mohammed , Ghorbani Elnaz , Khazaei Majid , Ryzhikov Mikhail , Avan Amir , Hassanian Seyed Mahdi
Published: September 2024

Hepatocellular carcinoma (HCC) is influenced by several factors, among which genetic polymorphisms
play a key role. Polymorphisms in various genes affect key pathways involved in HCC development,
including metabolism, expression of inflammatory cytokines, cell proliferation, and apoptosis regulation. These
polymorphisms induce differential effects on susceptibility to HCC, disease progression, and treatment outcomes.
Understanding the effect of genetic variations on HCC pathogenesis is essential to elucidate underlying
mechanisms and identify potential therapeutic targets. This review explores the diverse roles of genetic polymorphisms
in HCC, providing insights into the complex interplay between genetic factors and disease development.
Cationic Lipid Modification of Nuclear Hormone Receptor-Ligands: A Strategy for Developing a New Class of Targeted Anticancer Therapeutics
Authors: Yousuf Md , Banerjee Rajkumar
Published: September 2024

Ubiquitous expression patterns of nuclear hormone and their receptors (NHRs) have their own roles in performing essential functions in controlling
hormone responsive element-promoted gene transcription. In diseased states such as cancer, NHRs play crucial roles and hence targeting these
receptors are essential as it gives us a window of opportunity for developing targeted anticancer therapeutics. In comparison to traditional
chemotherapy drugs, targeted therapeutic drugs are hypothetically advantageous in terms of efficacy and safety and hence the idea of developing
such targeted drugs are inclined to become a mainstream cancer treatment option. This review selectively compiles data regarding NHR-targeting,
while majorly focusing on cancer treatment using anticancer small molecules and/or nanotherapeutics targeting estrogen receptor, progesterone
receptor, glucocorticoid receptor, and vitamin D receptor. In this study, we selectively emphasized on estrogen receptor. Herein, we mainly
highlight the strategy of lipid-modification to convert respective receptor ligands into NHR-targeted anticancer molecules as well as
nanotherapeutics. We focused on the strategy of chemical conjugation of those ligands with twin-aliphatic carbon chain-based cationic lipids. The
strategy successfully led to the development of a new class of anticancer therapeutics. These are either small-molecule anticancer agents or selfaggregating
nanotherapeutics. In spite of great anticancer output, the concept of NHR-targeted anti-cancer therapy still needs to overcome further
hurdles before those are projected for clinical settings.
The Benefits of Using Active Remote Patient Management for Enhanced Heart Failure Outcomes in Rural Cardiology Practice: Single-Site Retrospective Cohort Study
Authors: Craig William , Ohlmann Suzanne
Published: September 2024

Background

Rural populations have a disproportionate burden of heart failure (HF) morbidity and mortality, associated with socioeconomic and racial inequities. Multiple randomized controlled trials of remote patient monitoring (RPM) using both direct patient contact and device-based monitoring have been conducted to assess improvement in HF outcomes, with mixed results.

Objective

We aimed to assess whether a novel digital health care platform designed to proactively assess and manage patients with HF improved patient outcomes by preventing HF re-exacerbations, thus reducing emergency room visits and HF hospitalizations.

Methods

This was a single-site, retrospective cohort study using electronic medical record (EMR) data gathered from 2 years prior to RPM initiation and 2 years afterward. In January 2017, this single center began enrolling New York Heart Association (NYHA) class II and class III patients with HF prone to HF exacerbation into an RPM program using the Cordella HF system. By July 2022, 93 total patients had been enrolled in RPM. Of these patients, 87% lived in rural areas. This retrospective review included 40 of the 93 patients enrolled in RPM. These 40 were selected because they had 2 years of established EMR data prior to initiation of RPM and 2 years of post-RPM data; each consented to this Sterling IRB–approved study.

Results

We included 40 patients with at least 4 years of follow-up, including 2 years prior to RPM initiation and 2 years after RPM initiation. In the 2 years after RPM initiation, check-up calls increased 519%, medication change calls increased 519%, and total calls increased by 519%. Emergency room visits for HF fell 93%, heart failure hospitalizations fell 83%, and all other cardiovascular hospitalizations fell 50%. Additionally, the total number of office visits declined by 15% after RPM, and unscheduled or urgent office visits declined by 73%.

Conclusions

Daily monitoring of trends in vital sign data between engaged patients and a collaborative team of clinicians, incorporated into daily clinical workflow, enhanced patient interactions and allowed timely response or intervention when HF decompensation occurred, resulting in a reduction of outpatient and inpatient clinical use over more than 2 years of follow-up.
Current Evidence of the Application of Music in Tai Chi Exercise: Scoping Review
Authors: Du Yan , Wei Gao-Xia , He Yichao , Ning Hongting , Roberts Penny , Golob Edward , Yin Zenong
Published: September 2024

Background

Music has frequently been used in movement exercises to enhance health benefits. However, scientific evidence regarding the application of music to Tai Chi practice is limited.

Objective

This scoping review aims to understand how music has been used in Tai Chi practice and whether music could be applied to Tai Chi practice to help optimize its benefits.

Methods

PubMed, CINAHL, CNKI, and Weipu databases were searched. We included studies that compare Tai Chi practice experience or health outcomes between individuals practicing Tai Chi with music and those practicing Tai Chi without music. Studies published through September 2022 were identified. Two researchers (YD and YH) independently performed study selection and data extraction. Thematic analysis was used to summarize and categorize the findings of the included studies.

Results

Seven studies were included in this review. All 7 included studies are experimental studies. Practicing Tai Chi with music might lead to positive perceptions of Tai Chi practice (eg, motivation, concentration, enjoyment, compliance, and performance) and higher evaluations of Tai Chi instructional quality, especially for Tai Chi beginners. The effects of incorporating music into Tai Chi practice on health outcomes are inconclusive due to the heterogeneities of the sample size, and the intervention components, lengths, and frequencies of the included studies.

Conclusions

Applying music to Tai Chi practice may result in positive Tai Chi practice experience and adherence, particularly for beginners, which could help improve the dissemination and implementation of Tai Chi interventions for public health. However, whether applying music to Tai Chi practice leads to synergetic effects on health outcomes needs further investigation.
Red Blood Cell Transfusion for Incidence of Retinopathy of Prematurity: Prospective Multicenter Cohort Study
Authors: Wang Xiaoling , Rao Rui , Li Hua , Lei Xiaoping , Dong Wenbin
Published: September 2024

Background

Retinopathy of prematurity (ROP) is a leading cause of visual impairment and blindness in preterm infants.

Objective

This study sought to investigate the association between red blood cell (RBC) transfusion and ROP in very preterm infants (VPIs) to inform clinical strategies for ROP prevention and treatment.

Methods

We designed a prospective multicenter cohort study that included VPIs and follow-up data from January 2017 to December 2022 at 3 neonatal clinical medicine centers. They were categorized into a transfusion group (infants who received an RBC transfusion within 4 wk) and a nontransfusion group. The relationship between RBC transfusion and ROP incidence was assessed using binary logistic regression, with subgroup analyses based on gestational age, birth weight, sex, and sepsis status. Inverse probability of treatment weighting and propensity score matching were applied to account for all potential confounding factors that could affect ROP development, followed by sensitivity analysis.

Results

The study included 832 VPIs, including 327 in the nontransfusion group and 505 in the transfusion group. The transfusion group had a lower average birth weight and gestational age and a greater incidence of ROP, ≥stage 2 ROP, and severe ROP. Logistic regression analysis revealed that the transfusion group had a significantly greater risk of ROP (adjusted odds ratio [aOR] 1.70, 95% CI 1.14‐2.53, P=.009) and ≥stage 2 ROP (aOR 1.68, 95% CI 1.02‐2.78, P=.04) but not severe ROP (aOR 1.75, 95% CI 0.61‐5.02, P=.30). The trend analysis also revealed an increased risk of ROP with an increasing number of transfusions and a larger volume of blood transfused (P for trend<.001). Subgroup analyses confirmed a consistent trend, with the transfusion group at a higher risk for ROP across all subgroups. Inverse probability of treatment weighting and propensity score matching analyses supported the initial findings.

Conclusions

For VPIs, RBC transfusion significantly increases the risk of ROP, and the risk increases with an increasing number of transfusions and volume of blood transfused.
Hipiles yucatecos, flores multicolores. Estética e identidad sociocultural
Authors: Ruiz Ávila Dalia
Published: September 2024

Todo discurso posee una dimensión estética, cuya proporción varía de acuerdo con el tipo discursivo que se aborda y que puede ser analizada desde la interdisciplinariedad. Este trabajo se centra en el análisis del hipil que porta la mujer maya de la región de Los Chenes de la Península de Yucatán, en tanto texto constituido por códigos que interactúan y se integran a la construcción del yo/nosotros y el mundo. En esa prenda, elaborada a partir de una pieza de tela de algodón rectangular, decorada con un bordado alrededor del escote y en la orilla inferior, el diseño y los colores de las flores, hojas, animales, ramas y grecas, constituyen un lenguaje particular que trasciende el juicio estético y adquiere, en su contexto sociocultural, diversos significados para quien lo porta y para quien lo mira.
ANALISANDO A METODOLOGIA ATIVA SALA DE AULA INVERTIDA NA FORMAÇÃO DE PROFESSORES DO IFMT CAMPUS CONFRESA
Authors: Figueiredo Emerson de Oliveira , Pereira Gabriel Mateus Arantes
Published: September 2024

Este artigo teve como objetivo explorar a eficácia da metodologia de ensino ativa, especificamente a sala de aula invertida, na formação de licenciandos do IFMT – Campus Confresa. Para avaliar a eficácia da metodologia, foi utilizado um questionário online com perguntas fechadas e abertas. Os dados foram coletados de estudantes de diferentes licenciaturas, garantindo o anonimato e a voluntariedade na participação. Os resultados, analisados qualitativamente, mostraram que a metodologia utilizada aumentou significativamente o interesse e o engajamento dos alunos. A análise das respostas do questionário revelou melhorias no aprendizado e na participação, com a maioria dos estudantes reconhecendo um aumento na motivação e no envolvimento ativo na disciplina de didática. Os estudantes também identificaram desafios, como adaptação à leitura intensiva e participação em debates, refletindo uma transição educacional mais ativa e participativa.
Strategy Marketing Narasi TV
Authors: Sikumbang Syafei
Published: September 2024

This study aims to find out how Narasi.tv's marketing strategy is in producing messages that will be broadcast through social media youtube. Every stage that exists must be the result of the thoughts of professional officers who are members of a solid team. The stages of the production process that we want to study are the production of the Narasi.tv program which starts with Pre-Production, Production and Post-Production. The research method used is a case study with a qualitative approach, and the type of research is descriptive, the researchers used interviews. The results of the research that the researcher found that the production strategy started from planning with research by choosing interesting materials and the best crew. The trending material is to be made into a talk show program, while in production chooses the best resource persons, then in post-production the editor edits by making it interesting in the first minute and adding illustrations both audio and video to support the editing results.
Pola Penggunaan Aplikasi Transportasi Online di Kalangan Asisten Rumah Tangga
Authors: Hidayat Mochamad Taufiq , Hesti Sri , Nurhikmah Nurhikmah
Published: September 2024

This study aims to reveal and map patterns or models of information search for household assistants as consumers of users of online transportation services. Using a case study approach is expected to reveal consumer behavior patterns and information search models relating to new economic products that can be developed for new professions in Indonesia.The results showed there were differences in ART in the search for information, for personal interests such as work leave, going with friends to the Mall, delivering to the station, ordering food and there were some who used it to support their work. Usually they prefer cash payments, and take advantage of discount promos.In the study also found three behavioral patterns in ART, namely (1) the usual personal pattern of informants using applications for personal needs. (2) Work Support Patterns on ART that they usually use online transportation applications to support their work, and (3) Social Patterns, where use is intended to help other ART members who cannot use the application.
Taktik MPR Angan Coffee and Comfort Food Dalam Meningkatkan Awareness
Authors: Yemima Hana , Ayumi Shereina Sarah , Sinuraya Sofia , Perbawasari Susie , Anisa Renata
Published: September 2024

Changing technology and increasing information encourages acceleration and lifestyle improvement. The growing lifestyle in the upper middle class that prioritizes drinking coffee as one of the activities they must do. To increase market demand for the need to drink coffee, Angan Coffee & Comfort Food also attended to answer the needs of the community. There are several coffee shops that are also present, for that Angan need Marketing Public Relations (MPR) to be able to compete and have certain characteristics that can distinguish Angan with other coffee shops. The purpose of this research is to describe the MPR activities conducted by Angan, as well as to analyse the success of the activities of MPR Angan. The MPR activities conducted by Angan is a form of workshop activities involving the public. So through this MPR activities can occur interaction between Angan and its target market, besides the event held by Angan is an activity that is an interest of the public itself. The research methods used in this research are qualitative descriptive research, which in this research, researchers becoming the key instrument. The technique of data collection used is an interview with the owner of the research subject, Angan Coffee and Comfort Food, and observe to visit Angan Coffee & Comfort Food. The result of a pull strategy with tactics derived in the form of events such as workshops, resulted in an increase in the attention of local communities around Jakarta to Angan Coffee and Comfort Food.
teste submissao doi
Authors:   , neki
Published: September 2024

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Metodologia de execução de obras integrando BIM aos processos construtivos, projeto e execução
Authors:   , Mariano Daniel Felipe Pereira Iwai
Published: September 2024

O presente trabalho tem como objetivo o desenvolvimento de uma metodologia de execução de obras que integre o Building Information Modeling (BIM) aos processos construtivos de projeto e execução. Estima-se que, por meio da organização lógica dos processos e de um fluxo de etapas otimizadas, seja possível melhorar as técnicas e serviços atuais do setor da construção. Para tal, foram realizados estudos acerca do tema, a fim de gerar uma base de dados pautada na bibliografia existente, nos documentos relacionados e nos estudos de caso com escritórios previamente selecionados. Foi, então, elaborada uma proposta de metodologia de execução de obras, integrando o BIM aos processos construtivos. Em paralelo, ao decorrer da proposta da metodologia, foram realizados estudos comparativos entre os modelos de execução atuais e a metodologia proposta, que, ao final da pesquisa, correspondeu à abordagem de onze processos construtivos projetuais e vinte e quatro processos executivos. Os indicadores potencializados por meio da metodologia proposta correspondem ao tempo e ao custo das obras, pois um fluxo otimizado de etapas interage diretamente com tais fatores, estimando a melhoraria dos processos construtivos dos profissionais AEC. Contudo, ainda que haja vantagens, os resultados da pesquisa demonstram que BIM apresenta dificuldades para a sua implementação, principalmente pelas suas dificuldades de implementação e pela aceitação do uso da metodologia.
Seleção de microrganismos produtores de polihidroxialcanoato (PHA) e estudos para sua produção e aplicação
Authors:   , Gonzaga Márcia Féldreman Nunes
Published: September 2024

No início do século 20, ocorreu uma explosão no desenvolvimento tecnológico e industrial, que afetou também o uso de plástico na sociedade. O uso em larga escala, aliado à baixa degradação do plástico, induziram a consequências danosas ao meio ambiente, gerando problemas ecológicos como o acúmulo do material em aterros sanitários e a poluição de oceanos. Além do caráter ambiental, a produção de plástico convencional, desenvolvido a partir de recursos de petróleo, também se faz como um crescente problema no mundo. O presente trabalho teve por objetivo, triar cepas microbianas com capacidade de produção de PHA a partir de amostras do solo; avaliar o uso de lignina como fonte de carbono para os microrganismos visando a produção de biopolímeros em larga escala. Avaliar as características físico-químicas do biopolímeros produzidos. A produção biopolímeros sustentáveis em larga escala é esperada no Brasil, sendo vantajoso, à medida que favorece o crescimento e o desenvolvimento econômico e industrial do país. Para os ensaios, foram planejados experimentos observando o comportamento de diferentes cepas isoladas, identificando as classes e gêneros destes microrganismos, através do sequenciamento da região rDNA 16S e da região ITS, posteriormente, foi utilizado a epifluorescência por uso de corantes dos microrganismos com concentrações distintas de fonte de carbono, utilizando os corantes de Nile Blue A e Sudan Black B. Os métodos espectrofotométricos foram utilizados na determinação qualitativa dos poliésteres das células bacterianas, o ensaio ácido crotônico convertido atingiu o pico confirmatório de hidrolização, o que confirma que as condições cultivadas em e acréscimo de substratos de carbono fornecidos foram adequadas. Os picos referentes do espectro de FTIR O espectro de FTIR representa o trecho característico de monômeros, os resultados confirmaram a produção de PHA biogênicos extraídos na presente pesquisa, sendo comparável com o espectro de FTIR para os polímeros de PHA. Outros fatores podem ser considerados à busca pelo aumento nesta produção como, por exemplo, induzir estresse ao microrganismo produtor, explorar largamente a aplicação da lignina como recurso flexível sustentável como fonte de carbono. Outra sugestão, é a utilização novos processos de extração do biopolímero por solventes não tóxicos, favorecendo a sustentabilidade e viabilidade econômica para a indústria.
The restructuring of credit and lease agreements and its impact on micro, small, and medium-sized enterprise and insolvency risks amid the pandemic: A normative juridical method
Authors: Badriyah Siti Malikhatun , Suharto R. , Saraswati Retno
Published: September 2024

Micro, small, and medium-sized enterprises (MSMEs) play a crucial role in Indonesia’s economy, contributing to job creation, income growth, and wealth distribution (Koeswahyono et al., 2022). This research aims to analyze the impact of the COVID-19 pandemic on lease agreements (leasing) in the non-banking financial sector, particularly in financing companies. The research is conducted through a normative juridical research method. The main findings of this study show that credit restructuring is a government solution to address instalment payment difficulties, especially for MSME debtors. The article also addresses legal certainty issues in lease agreements, mainly due to regulatory gaps in the Civil Code. With specific conditions, credit restructuring is provided with a maximum limit of IDR 10 billion (Siregar et al., 2021). This research concludes that, despite being considered an optimal solution, credit restructuring also has negative impacts, and legal certainty is critical in this context. Using data from the Financial Services Authority in 2021, the article explains that credit restructuring has positively stimulated Indonesia’s economic growth. MSME debtors are the main focus, comprising 39.73 percent of the total credit restructuring. This policy is seen as a strategic step to support economic recovery, especially considering the central role of MSMEs in the national economy.
In vitro assessment of the nematicidal potential of Streptomyces violascens strain AS2 against root-knot nematodes (Meloidogyne sp.)
Authors: Azlay Latifa , Oubassou Ez-Zahra , Berr Alexandre , Mayad El Hassan , Barakate Mustapha
Published: September 2024

Root-knot nematodes (RKNs, Meloidogyne spp.) present a major challenge to sustainable production. The detrimental environmental impacts and increasing resistance associated with synthetic nematicides have increased the need for biocontrol alternatives. Here, we report for the first time the nematicidal properties of Streptomyces violascens and its viability as a safe and effective solution against nematode infestation. In vitro assays showed that aqueous and ethyl acetate extracts of S. violascens significantly impeded Meloidogyne sp?s reproductive and locomotive functions. The aqueous extract displayed remarkable efficacy, completely inhibiting egg hatching at a concentration of 600 ?g/mL, with an LC50 of 168.38 ?g/mL, and causing 99% immobility of second-stage juveniles (J2s) at 800 ?g/mL within 72 h. Conversely, the organic extract exhibited a 29.3% hatching rate (LC50 of 849.26 ?g/mL) and 79% immobility of J2s under comparable conditions. These findings point to the robust nematicidal potential of S. violascens extracts. Enzymatic profiles supported these results, with the selected isolate producing chitinase and protease enzymes capable of degrading nematode eggshells. Our results show that the S. violascens strain can be integrated into a sustainable nematode management practice as an important agent of RKN biocontrol.
Comparison of Diabetes Education Content Experienced by Blind and Nonblind People With Diabetes
Authors: Heydarian Nazanin , Hussein Qusay , Guerra Zully , Patel Bhumi , Hughes Allyson S. , Blanchette Julia E. , Castro Yessenia
Published: September 2024

This survey sought to examine disparities in diabetes self-management education and support (DSMES) to illuminate gaps underlying morbidity and mortality disparities experienced by blind people with diabetes and develop a pathway for improved health care delivery and health outcomes. Blind participants were more likely to report getting DSMES on strategies to promote treatment adherence and noncompliance with medical regimen; yet, blind and nonblind participants did not differ on primary care provider visits or amount of time spent in diabetes education. These findings suggest that DSMES content may differ for blind versus nonblind participants.
Home self-testing of complete blood counts in patients with breast cancer during chemotherapy: A proof-of-concept cohort study in e-oncology
Authors: Friis-Hansen Lennart , Bjørck Pippi Jonassen , Hartvig Ditte , Andresen Susanne , Nielsen Berit Hulehøj , Hansen Christina , Nistrup Anne , Hundewadt Keld , Holländer Niels Henrik
Published: September 2024

Background: Before administration of myelosuppressive chemotherapy, complete blood counts (CBC) collected at the hospital/nursing stations are evaluated to avoid severe bone marrow suppression. This maintains disease fixation which often reduces their quality of life. This mixed-method study examined at home self-testing of CBC, the test quality, and the effects on patients’ mental well-being.
Methods: Patients with breast cancer receiving chemotherapy were recruited and trained to perform capillary finger prick CBC testing at home using the HemoScreen Point-of-Care instrument and to upload the test results to the hospital’s IT system subsequently. A venous reference CBC sample was taken and tested at the hospital on the day of self-testing. Semi-structured interviews with open-ended components were performed to investigate the user experience and the impact of self-testing on the patients’ everyday lives.
Results: Thirty-nine patients completed the self-testing education using the HemoScreen instrument. Eight patients withdrew, while the remaining 31 patients performed 161 home tests (2–11 tests per patient) over a 4-month period. The test results compared well with the venous reference CBCs except for platelet counts (correlation coefficient 0.26). Qualitative interviews with nine of the 31 patients emphasized that the patients were comfortable using the self-testing instrument and becoming an active partner in their own treatment.
Interpretation: CBC self-testing at home produced clinically valid hemoglobin and white blood cell counts with the added benefit that the patients became active partners in their own treatment course, which was of great importance for the patients and increased their wellbeing.
Computer-Aided Design, Synthesis, and Evaluation of Novel Broad-Spectrum Antiviral Agents
Authors:   , Flude Ben
Published: September 2024

An important new tool in combating viral disease is the creation and use of broad-spectrumant ivirals. In the post-COVID pandemic world, the need for such drugs is more evident than ever. In this work, potential broad-spectrum antiviral agents have been developed for two families of viruses, Clade B of the New World arenaviruses, and the highly pathogenic human coronaviruses. This has been achieved by identifying conserved protein-protein interactions within the virus families using in silico techniques, for which inhibitors have been designed and synthesised, and the inhibitory activities quantified by in vitro testing. In the case of New World arenaviruses, previous work completed in group had identified two hit antiviral molecules, for which different series of diverse analogues have been synthesised and evaluated for inhibition of the interaction between the viral glycoprotein 1 and host human transferrin receptor 1, the protein-protein interaction required for cell entry for all members of Clade B. For the highly pathogenic human coronaviruses, an in-silico interaction model was created for the conserved interaction between the viral nucleocapsid protein and host mannose-binding lectin associated serine protease 2, which was used as the basis for a drug repurposing study and a virtual screening of a drug-like small molecule library, from which two hit molecules have been identified. In parallel to this structure-based approach, a ligand-based approach was also taken using a conserved amino acid sequence found in the nucleocapsid proteins that is responsible for the protein-protein interaction, from which novel peptidomimetic molecules were designed, and a synthetic route for these compounds has been optimised. Multiple series of anti-arenavirus molecules have been synthesised, identifying two species that have progressed into in vivo studies, showing improved activity over the previously identified hit molecule. A protein-protein interaction model of MASP-2 in complex with the N protein of SARS-CoV-2 has been developed, used as the basis for a virtual screening study identifying two hit molecules, with a series of peptidomimetic molecules being designed and a suitable synthetic route created based on the interacting sequence of the SARS-CoV-2 N protein.
ANALISIS PANCASILA SEBAGAI WELTANSCHAUUNG BAGI KEHIDUPAN BERBANGSA
Authors: Sugiharto  , Dwi Arifin Lubis Juliana , Rahman Anisa , Wijaya Aris , Sartika Rinny
Published: September 2024

Pancasila as a weltanschauung has a very important role in directing the behavior and life of Indonesian society. By integrating the noble values ​​of the Indonesian nation, Pancasila becomes a moral compass and guideline in society and the state. The implementation of Pancasila values ​​in national and state life covers various aspects, such as social, political and cultural life. However, the implementation of Pancasila is also faced with various challenges and obstacles, such as limited awareness, limited resources and legal limitations. To overcome these challenges, strong awareness and commitment is needed from the community and government in developing the values ​​of Pancasila and maintaining a peaceful and prosperous national and state life. The approach taken is a literature study by examining several sources that are relevant to the analysis of Pancasila as a part of national life. Based on a literature study approach where the author collects data and information in the form of documents, discussion books, journals, articles and others.
Reduction of Carbon Assimilation and Water Use Efficiency in Groundnut Ringspot Virus (GRSV)-Infected Groundnut Varieties
Authors: Appiah Andrew Sarkodie , Amponsah Jonathan , Afful Nusrat Tsemah , Ocloo Fidelis , Amiteye Samuel , Sarfo Mark Kwasi , Kusi-Adjei Rosemary , Otu Solomon Ayeboafo , Annor Clement , Ayeh Kwadwo Owusu , Asare-Bediako Elvis
Published: September 2024

Groundnut (Arachis hypogaea L.) production is threatened by the advent of many emerging pests and diseases, key among them being Groundnut ringspot virus (GRSV). The numerous alternative host crops of the virus make its control particularly difficult, resulting in heightened virus transmission risk and increased yield loss. The mechanisms underlying yield loss, though not fully understood, have often been speculated to be a result of the reduction in photosynthesis and transpiration in infected leaves. This study was therefore aimed at testing the effect of GRSV infection on carbon assimilation and water use efficiency by four farmer preferred groundnut cultivars (Nkosuor, Otuhia, Sinka, and Yenyawoso) in Ghana. Seeds of virus indexed plants previously grown in a screen house were nursed in a screen house and artificially infected with GRSV by grafting infected groundnut scions onto them to be compared with plants onto which uninfected groundnut scions had been grafted. The rate of photosynthesis, transpiration, and stomatal conductance of the distal leaf of each plant was measured using the CO2/H2O gas analyzer (CID, Inc., Camas, WA, USA). The virus infection was found to reduce stomatal conductance, transpiration, net photosynthesis, and 100 seed weight in a genotype dependent manner. This highlights the effect of GRSV infection on water conservation through a reduction in transpirational water loss, constraining photosynthesis, or carbon assimilation in the process to confirm the trade-off between photosynthesis and transpiration through the stomata.
Policy-oriented Research and Island Management Within Island Studies
Authors: Yu Jiamin , Yang Lin
Published: September 2024

This paper introduces the special section on ‘Policy-oriented research and island management within island studies’. The paper discusses island studies’ relationship with and engagement with policy-oriented research and the world of practice. It asks how island studies can learn from and influence trends elsewhere within global academia as well as how it best can influence the sustainable management of island communities.
Propositional Idea Density in the Writing of Native Speakers and Asian Learners of English: A Corpus-Based Contrastive Interlanguage Analysis
Authors: Mutlib Sayer Inaad , Hammo Mzeil Ahmad
Published: September 2024

The present study is a contrastive interlanguage analysis of propositional idea density in the written language of native English speakers and Asian learners of English. The study adopted a quantitative method to analyse the ICNALE written essays v2.4 using CPIDR v5.1 software. The study aimed to identify the level of propositional idea density in the writing of English native speakers and Asian learners of English and to examine the effect of the type of English, the theme type, the proficiency level and nationality on propositional idea density. The study is one of the very few studies about propositional idea density in ESL and EFL contexts. Many statistical analyses were performed on CPIDR results using jamovi v2.3 software, and the results of the tests revealed that the propositional idea density in native speakers’ essays was higher than that in Asian learners’ essays. Moreover, the results showed that there was a statistically significant difference among all the participants based on the theme types of part-time jobs and smoking, among native speakers based on occupation type (students, teachers, others) and among Asian learners of English based on the type of English proficiency level and nationality. The findings of the study showed that propositional idea density is a psycholinguistic index of the amount of presupposed knowledge language users have on a specific topic. In other words, propositional idea density is a window to language users’ schemata. Additionally, the findings of the study can be considered an insightful contribution to contrastive interlanguage analysis.