bluuebunny/crossref_metadata_2025 huggingface dataset:
Glycopyranosylidene-Spiro-Morpholinones: Evaluation of the Synthetic Possibilities Based on Glyculosonamide Derivatives and a New Method for the Construction of the Morpholine Ring
Authors: Kánya Nándor , Kun Sándor , Somsák László
Published: November 2022

Glycosylidene-spiro-morpholin(on)es are scarcely described skeletons in the literature. In this work, we have systematically explored the synthetic routes towards such morpholinones based on the reactions of O-peracylated hept-2-ulopyranosonamide derivatives of D-gluco and D-galacto configuration. Koenigs–Knorr type glycosylation of 2-chloroethanol, allylic and propargylic alcohols by (glyculosylbromide)onamides furnished the expected glycosides. The 2-chloroethyl glycosides were ring closed to the corresponding spiro-morpholinones by treatment with K2CO3. The (allyl glyculosid)onamides gave diastereomeric mixtures of spiro-5-hydroxymorpholinones by ozonolysis and 5-iodomethylmorpholinones under iodonium ion mediated conditions. The ozonolytic method has not yet been known for the construction of morpholine rings, therefore, it was also extended to O-allyl mandelamide. The 5-hydroxymorpholinones were subjected to oxidation and acid catalyzed elimination reactions to give the corresponding morpholine-3,5-dions and 5,6-didehydro-morpholin-3-ones, respectively. Base induced elimination of the 5-iodomethylmorpholinones gave 5-methyl-2H-1,4-oxazin-3(4H)-ones. O-Acyl protecting groups of all of the above compounds were removed under Zemplén conditions. Some of the D-gluco configured unprotected compounds were tested as inhibitors of glycogen phosphorylase, but showed no significant effect.
Rhodophyta as Potential Sources of Photoprotectants, Antiphotoaging Compounds, and Hydrogels for Cosmeceutical Application
Authors: Kasanah Noer , Ulfah Maria , Imania Okmalisda , Hanifah Annisa Nur , Marjan Muhammad Idham Darussalam
Published: November 2022

Seaweeds are macroscopic, multicellular, eukaryotic and photosynthetic organisms, and are a source of chemical diversity with powerful biological activities for diversified industrial applications including cosmeceuticals. Red seaweeds (Rhodophyta) are good sources of Mycosporine-like amino acids (MAA) for photoprotectant and antiphotoaging compounds. In addition, Rhodophyta are also good sources for hydrogel compounds that are used widely in the food, pharmaceutical and cosmeceutical industries as gelling agents, moisturizers or for their antiphotoaging effects. Our survey and ongoing studies revealed that the biodiversity of Indonesian Rhodophyta is rich and is a treasure trove for cosmeceutical agents including MAA and hydrogels. This study delivers valuable information for identifying potential red seaweeds in screening and searching for cosmeceutical agents.
Antibacterial, Antioxidant, Larvicidal and Anticancer Activities of Silver Nanoparticles Synthesized Using Extracts from Fruits of Lagerstroemia speciose and Flowers of Couroupita guianensis
Authors: Babu Venkatadri , Arokiyaraj Selvaraj , Sakthi Sri Swathi Pon , George Mary , Ragavan Rameshkumar Marimuthu , Dharmalingam Dinesh , Oh Taehwan , Ramasundaram Subramaniyan , Agastian Paul
Published: November 2022

The present study aimed to analyze the in vitro antibacterial, antioxidant, larvicidal and cytotoxicity properties of green synthesized silver nanoparticles (Ag NPs) using aqueous extracts from fruits of Lagerstroemia speciosa and flowers of Couropita guinensis. Synthesized Ag NPs were characterized using UV-DRS, FTIR, XRD, DLS, and High-Resolution SEM and TEM analyses. Absorption wavelength was observed at 386 nm by UV-DRS analysis and energy band gap was calculated as 3.24 eV. FTIR analysis showed the existence of various functional groups in the aqueous extract and in the NPs. DLS analysis showed the stability and particle size of the synthesized Ag NPs. SEM analysis revealed that Ag NPs are in a face centered cubic symmetry and spherical shape with a size of 23.9 nm. TEM analysis showed particle size as 29.90 nm. Ag NPs showed antibacterial activity against both Gram-positive and Gram-negative bacteria. DPPH scavenging trait of Ag NPs was ranging from 20.0 ± 0.2% to 62.4 ± 0.3% and observed significant larvicidal activity (LC50 at 0.742 ppm and LC90 at 6.061 ppm) against Culex quinquefasciatus. In vitro cytotoxicity activity of Ag NPs was also tested against human breast cancer (MCF-7) and fibroblast cells (L-929) and found that cells viabilities are ranging (500 to 25 µg/mL) from 52.5 ± 0.4 to 94.0 ± 0.7% and 53.6 ± 0.5 to 90.1 ± 0.8%, respectively. The synthesized Ag NPs have the potential to be used in the various biomedical applications.
Trend in Research on Characterization, Environmental Impacts and Treatment of Oily Sludge: A Systematic Review
Authors: Niu Anyi , Sun Xuechao , Lin Chuxia
Published: November 2022

Oily sludge is a hazardous material generated from the petroleum industry that has attracted increasing research interest. Although several review articles have dealt with specific subtopics focusing on the treatment of oily sludge based on selected references, no attempt has been made to demonstrate the research trend of oily sludge comprehensively and quantitatively. This study conducted a systematic review to analyze and evaluate all oily sludge-related journal articles retrieved from the Web of Science database. The results show that an increase in oily sludge-related research did not take place until recent years and the distribution of the researchers is geographically out of balance. Most oily sludge-related articles focused on treatment for harmfulness reduction or valorization with limited coverage of formation, characterization, and environmental impact assessment of oily sludge. Pyrolytic treatment has attracted increasing research attention in recent years. So far, the research findings have been largely based on laboratory-scale experiments with insufficient consideration of the cost-effectiveness of the proposed treatment methods. Although many methods have been proposed, few alone could satisfactorily achieve cost-effective treatment goals. To enable sustainable management of oily sludge on a global scale, efforts need to be made to fund more research projects, especially in the major oil-producing countries. Pilot-scale experiments using readily available and affordable materials should be encouraged for practical purposes. This will allow a sensible cost-benefit analysis of a proposed method/procedure for oily sludge treatment. To improve the treatment performance, combined methods are more desirable. To inform the smart selection of methods for the treatment of different oily sludge types, it is suggested to develop universally accepted evaluation systems for characterization and environmental risk of oily sludge.
Essential Oils and Their Compounds as Potential Anti-Influenza Agents
Authors: Oriola Ayodeji Oluwabunmi , Oyedeji Adebola Omowunmi
Published: November 2022

Essential oils (EOs) are chemical substances, mostly produced by aromatic plants in response to stress, that have a history of medicinal use for many diseases. In the last few decades, EOs have continued to gain more attention because of their proven therapeutic applications against the flu and other infectious diseases. Influenza (flu) is an infectious zoonotic disease that affects the lungs and their associated organs. It is a public health problem with a huge health burden, causing a seasonal outbreak every year. Occasionally, it comes as a disease pandemic with unprecedentedly high hospitalization and mortality. Currently, influenza is managed by vaccination and antiviral drugs such as Amantadine, Rimantadine, Oseltamivir, Peramivir, Zanamivir, and Baloxavir. However, the adverse side effects of these drugs, the rapid and unlimited variabilities of influenza viruses, and the emerging resistance of new virus strains to the currently used vaccines and drugs have necessitated the need to obtain more effective anti-influenza agents. In this review, essential oils are discussed in terms of their chemistry, ethnomedicinal values against flu-related illnesses, biological potential as anti-influenza agents, and mechanisms of action. In addition, the structure-activity relationships of lead anti-influenza EO compounds are also examined. This is all to identify leading agents that can be optimized as drug candidates for the management of influenza. Eucalyptol, germacrone, caryophyllene derivatives, eugenol, terpin-4-ol, bisabolene derivatives, and camphecene are among the promising EO compounds identified, based on their reported anti-influenza activities and plausible molecular actions, while nanotechnology may be a new strategy to achieve the efficient delivery of these therapeutically active EOs to the active virus site.
Secondary Structure Characterization of Glucagon Products by Circular Dichroism and Nuclear Magnetic Resonance Spectroscopy
Authors: Bao Zhongli , Cheng Ya-Chi , Wei Justin Jun , Luo Mary Ziping , Zhang Jack Yongfeng
Published: November 2022

Glucagon, a 29-amino acid polypeptide hormone, is an essential therapeutic agent used in the emergency treatment of hypoglycemia. However, glucagon is inherently unstable in aqueous solution. While glucagon equilibrates between unordered and the secondary α-helix state in solution, it can quickly transform into a different secondary β-sheet-rich amyloid-like fibril/oligomer structure under various conditions. Since changes in the secondary structure of glucagon can cause significant impacts, structure analysis is necessary and essential to assess the safety of the product. This study analyzed the secondary structure of glucagon products at the release and at the expiry using circular dichroism spectroscopy (CD) and 2D Nuclear Overhauser effect spectroscopy (2D NOESY). In order to also determine if structural differences exist between glucagon produced through different manufacturing processes, synthetic and recombinant glucagon products were used and compared. The CD results indicated that for all release and expired glucagon products, the structure compositions were 14 to 16% α-helix, 17 to 19% β-strand, 14 to 15% Turn, and 53 to 54% Unordered. This was consistent with the 2D NOESY analysis which showed that both products had an approximate α-helix composition of 14 to 17%. Overall, there were no significant differences in terms of the secondary structure between synthetic and recombinant glucagon products both at the release and at the expiry.
Effect of Functionalized Benzene Derivatives as Potential Hole Scavengers for BiVO4 and rGO-BiVO4 Photoelectrocatalytic Hydrogen Evolution
Authors: Sharifi Tayebeh , Kovačić Marin , Belec Monika , Perović Klara , Popović Marin , Radić Gabrijela , Žener Boštjan , Pulitika Anamarija , Kraljić Roković Marijana , Lavrenčič Štangar Urška , Lončarić Božić Ana , Kušić Hrvoje
Published: November 2022

Sustainable hydrogen production is one of the main challenges today in the transition to a green and sustainable economy. Photocatalytic hydrogen production is one of the most promising technologies, amongst which BiVO4-based processes are highly attractive due to their suitable band gap for solar-driven processes. However, the performance of BiVO4 alone in this role is often unsatisfactory. Herein we report the improvement of BiVO4 performance with reduced graphene oxide (rGO) as a co-catalyst for the photoelectrochemical water splitting (PEC-WS) in the presence of simple functionalized benzene derivatives (SFBDs), i.e., phenol (PH), benzoic acid (BA), salicylic acid (SA), and 5-aminosalicylic acid (5-ASA) as potential photogenerated hole scavengers from contaminated wastewaters. Linear sweep voltammetry and chronoamperometry, along with electrochemical impedance spectroscopy were utilized to elucidate PEC-WS performance under illumination. rGO has remarkably improved the performance of BiVO4 in this role by decreasing photogenerated charge recombination. In addition, 5-ASA greatly improved current densities. After 120 min under LED illumination, 0.53 μmol of H2 was produced. The type and concentration of SFBDs can have significant and at times opposite effects on the PEC-WS performance of both BiVO4 and rGO-BiVO4.
Rosmarinic Acid Prevents Cisplatin-Induced Liver and Kidney Injury by Inhibiting Inflammatory Responses and Enhancing Total Antioxidant Capacity, Thereby Activating the Nrf2 Signaling Pathway
Authors: Xiang Yifei , Ji Min , Wu Liqin , Lv Li , Liang Qiuling , Deng Ruihan , Deng Zhaoyou , Liu Xia , Ren Lingyi , Feng Xin , He Jiakang
Published: November 2022

Drug-induced liver and kidney damage is an emergent clinical issue that should be addressed. Rosmarinic acid (RA) has obvious anti-inflammatory and antioxidant effects, so we evaluated the anti-inflammatory and antioxidant effects of RA pretreatment on serum and liver and kidney tissues of cisplatin (CP)-treated mice and explored the possible mechanisms. The results showed that RA pretreatment effectively downregulated the serum, liver, and kidney levels of ALT, AST, BUN, and CRE and the inflammatory factors IL-1β, IL-6, and TNF-α, and simultaneously enhanced the total antioxidant capacity of the liver and kidney. RA pretreatment significantly reduced the levels of MPO, MDA, and NO in liver and kidney tissue, inhibited the mRNA expression of IL-1β, IL-6, and TNF-α in liver and kidney tissue, activated the Nrf2 signaling pathway, and upregulated the mRNA expression of downstream target genes. Our findings show that RA could effectively prevent and alleviate acute liver and kidney injury caused by CP.
Building Polymeric Framework Layer for Stable Solid Electrolyte Interphase on Natural Graphite Anode
Authors: Zhao Yunhao , Wang Yueyue , Liang Rui , Zhu Guobin , Xiong Weixing , Zheng Honghe
Published: November 2022

The overall electrochemical performance of natural graphite is intimately associated with the solid electrolyte interphase (SEI) layer developed on its surface. To suppress the interfacial electrolyte decomposition reactions and the high irreversible capacity loss relating to the SEI formation on a natural graphite (NG) surface, we propose a new design of the artificial SEI by the functional molecular cross-linking framework layer, which was synthesized by grafting acrylic acid (AA) and N,N′−methylenebisacrylamide (MBAA) via an in situ polymerization reaction. The functional polymeric framework constructs a robust covalent bonding onto the NG surface with —COOH and facilitates Li+ conduction owing to the effect of the —CONH group, contributing to forming an SEI layer of excellent stability, flexibility, and compactness. From all the benefits, the initial coulombic efficiency, rate performance, and cycling performance of the graphite anode are remarkably improved. In addition, the full cell using the LiNi0.5Co0.2Mn0.3O2 cathode against the modified NG anode exhibits much-prolonged cycle life with a capacity retention of 82.75% after 500 cycles, significantly higher than the cell using the pristine NG anode. The mechanisms relating to the artificial SEI growth on the graphite surface were analyzed. This strategy provides an efficient and feasible approach to the surface optimization for the NG anode in LIBs.
In Vivo Antidepressant-Like Effect Assessment of Two Aloysia Species in Mice and LCMS Chemical Characterization of Ethanol Extract
Authors: Taboada Teresa , Alvarenga Nelson L. , Galeano Antonia K. , Arrúa Wilfrido J. , Campuzano-Bublitz Miguel A. , Kennedy María L.
Published: November 2022

Medicinal plants belonging to the Verbenaceae family demonstrated antidepressant effects in preclinical studies. Depression is one of the largest contributors to the global health burden of all countries. Plants from the Aloysia genus are traditionally used for affective disorders, and some of them have proven anxiolytic and antidepressant activity. The aim of this work was to evaluate the antidepressant effect of the ethanolic extract of Aloysia gratissima var. gratissima (Agg) and Aloysia virgata var. platyphylla (Avp) in mice. A tail suspension test (TST) and forced swimming test (FST) were conducted after three doses in a period of 24 h and after 7 days of treatment. Imipramine was used as an antidepressant drug. The main results demonstrated that Agg extract reduced the immobility time in mice treated orally for 7 consecutive days when compared to the control group (reduced by about 77%, imipramine 70%). Animals treated with three doses of Avp in a 24-h period had reduced immobility time in the FST (60%), and after 7 days of treatment the reduction was greater (Avp 50, 100, and 200 about 85%; Avp 400, 96.5%; p < 0.0001, imipramine, 77%). LCMS analysis showed the presence of verbascoside, hoffmaniaketone, and hoffmaniaketone acetate in both, A. virgata var. platyphylla and A. gratissima var gratissima. The flavonoids nepetin and 6-hydroxyluteolin were also found in Agg. Both tested extracts demonstrated promising antidepressant-like activity in mice.
Collective Effects in Ionic Liquid [emim][Tf2N] and Ionic Paramagnetic Nitrate Solutions without Long-Range Structuring
Authors: Kume Eni , Martin Nicolas , Dunne Peter , Baroni Patrick , Noirez Laurence
Published: November 2022

Mesoscopic shear elasticity has been revealed in ordinary liquids both experimentally by reinforcing the liquid/surface interfacial energy and theoretically by nonextensive models. The elastic effects are here examined in the frame of small molecules with strong electrostatic interactions such as room temperature ionic liquids [emim][Tf2N] and nitrate solutions exhibiting paramagnetic properties. We first show that these charged fluids also exhibit a nonzero low-frequency shear elasticity at the submillimeter scale, highlighting their resistance to shear stress. A neutron scattering study completes the dynamic mechanical analysis of the paramagnetic nitrate solution, evidencing that the magnetic properties do not induce the formation of a structure in the solution. We conclude that the elastic correlations contained in liquids usually considered as viscous away from any phase transition contribute in an effective way to collective effects under external stress whether mechanical or magnetic fields.
Effects of Natural Polyphenols on Skin and Hair Health: A Review
Authors: Sun Mang , Deng Ya , Cao Xining , Xiao Lu , Ding Qian , Luo Fuqing , Huang Peng , Gao Yuanyuan , Liu Mengqi , Zhao Hengguang
Published: November 2022

The skin is the largest organ of the body and plays multiple essential roles, ranging from regulating temperature, preventing infections, to ultimately affecting human health. A hair follicle is a complex cutaneous appendage. Skin diseases and hair loss have a significant effect on the quality of life and psychosocial adjustment of individuals. However, the available traditional drugs for treating skin and hair diseases may have some insufficiencies; therefore, a growing number of researchers are interested in natural materials that could achieve satisfactory results and minimize adverse effects. Natural polyphenols, named for the multiple phenolic hydroxyl groups in their structures, are promising candidates and continue to be of scientific interest due to their multifunctional biological properties and safety. Polyphenols have a wide range of pharmacological effects. In addition to the most common effect, antioxidation, polyphenols have anti-inflammatory, bacteriostatic, antitumor, and other biological effects associated with reduced risk of a number of chronic diseases. Various polyphenols have also shown efficacy against different types of skin and hair diseases, both in vitro and in vivo, via different mechanisms. Thus, this paper reviews the research progress in natural polyphenols for the protection of skin and hair health, especially focusing on their potential therapeutic mechanisms against skin and hair disorders. A deep understanding of natural polyphenols provides a new perspective for the safe treatment of skin diseases and hair loss.
Jute Fibers Synergy with nZVI/GO: Superficial Properties Enhancement for Arsenic Removal in Water with Possible Application in Dynamic Flow Filtration Systems
Authors: Moreno-Bárcenas Alejandra , Arizpe-Zapata Jesús Alejandro , Rivera Haro Julio Alejandro , Sepúlveda Pamela , Garcia-Garcia Alejandra
Published: November 2022

Groundwater is one of the primary sources of water for both drinking and industrial use in northeastern Mexican territory, around 46% of the total, due to the lack of precipitation during the year and solar radiation index. The presence of arsenic in brackish soil and groundwater is a severe health issue, specifically in semi-arid and arid regions in the north of Mexico. Additionally, it represents the only source of drinking water in communities far from big cities, mainly due to the absence of hydric infrastructure. This work presents a new approach to treating polluted water with arsenic. The system based on activating jute fiber with nanoparticles of zero-valent iron immobilized over graphene oxide will allow nZVI particles to preserve their unique qualities for water sanitization. A dynamic flow test was designed to determine the effectivity of activated jute fibers as a water sanitation system. The results showed a reduction in the total arsenic content from 350 ppb to 34 ppb with a filtrate flow of 20 mL/min. The above represents 90% adsorption by the activated fiber. The analyzed sample corresponds to contaminated groundwater taken from Coahuila, Mexico. This sanitation system could be applied to low-income populations lacking robust infrastructure, such arsenic treatment plants.
Lanthanide(III) Ions and 5-Methylisophthalate Ligand Based Coordination Polymers: An Insight into Their Photoluminescence Emission and Chemosensing for Nitroaromatic Molecules
Authors: Pajuelo-Corral Oier , Razquin-Bobillo Laura , Rojas Sara , García Jose Angel , Choquesillo-Lazarte Duane , Salinas-Castillo Alfonso , Hernández Ricardo , Rodríguez-Diéguez Antonio , Cepeda Javier
Published: November 2022

The work presented herein reports on the synthesis, structural and physico-chemical characterization, luminescence properties and luminescent sensing activity of a family of isostructural coordination polymers (CPs) with the general formula [Ln2(μ4-5Meip)3(DMF)]n (where Ln(III) = Sm (1Sm), Eu (2Eu), Gd (3Gd), Tb (4Tb) and Yb (5Yb) and 5Meip = 5-methylisophthalate, DMF = N,N-dimethylmethanamide). Crystal structures consist of 3D frameworks tailored by the linkage between infinite lanthanide(III)-carboxylate rods by means of the tetradentate 5Meip ligands. Photoluminescence measurements in solid state at variable temperatures reveal the best-in-class properties based on the capacity of the 5Meip ligand to provide efficient energy transfers to the lanthanide(III) ions, which brings intense emissions in both the visible and near-infrared (NIR) regions. On the one hand, compound 5Yb displays characteristic lanthanide-centered bands in the NIR with sizeable intensity even at room temperature. Among the compounds emitting in the visible region, 4Tb presents a high QY of 63%, which may be explained according to computational calculations. At last, taking advantage of the good performance as well as high chemical and optical stability of 4Tb in water and methanol, its sensing capacity to detect 2,4,6-trinitrophenol (TNP) among other nitroaromatic-like explosives has been explored, obtaining high detection capacity (with Ksv around 105 M−1), low limit of detection (in the 10−6–10−7 M) and selectivity among other molecules (especially in methanol).
Development of Efficient and Recyclable ZnO–CuO/g–C3N4 Nanocomposite for Enhanced Adsorption of Arsenic from Wastewater
Authors: Khan Qudrat Ullah , Begum Nabila , Rehman Zia Ur , Khan Afaq Ullah , Tahir Kamran , Tag El Din El Sayed M. , Alothman Asma A. , Habila Mohamed A. , Liu Dahai , Bocchetta Patrizia , Javed Muhammad Sufyan
Published: November 2022

Arsenic (III) is a toxic contaminant in water bodies, especially in drinking water reservoirs, and it is a great challenge to remove it from wastewater. For the successful extraction of arsenic (III), a nanocomposite material (ZnO–CuO/g–C3N4) has been synthesized by using the solution method. The large surface area and plenty of hydroxyl groups on the nanocomposite surface offer an ideal platform for the adsorption of arsenic (III) from water. Specifically, the reduction process involves a transformation from arsenic (III) to arsenic (V), which is favorable for the attachment to the –OH group. The modified surface and purity of the nanocomposite were characterized by SEM, EDX, XRD, FT–IR, HRTEM, and BET models. Furthermore, the impact of various aspects (temperatures, pH of the medium, the concentration of adsorbing materials) on adsorption capacity has been studied. The prepared sample displays the maximum adsorption capacity of arsenic (III) to be 98% at pH ~ 3 of the medium. Notably, the adsorption mechanism of arsenic species on the surface of ZnO–CuO/g–C3N4 nanocomposite at different pH values was explained by surface complexation and structural variations. Moreover, the recycling experiment and reusability of the adsorbent indicate that a synthesized nanocomposite has much better adsorption efficiency than other adsorbents. It is concluded that the ZnO–CuO/g–C3N4 nanocomposite can be a potential candidate for the enhanced removal of arsenic from water reservoirs.
Carbon Fabric Decorated with In-Situ Grown Silver Nanoparticles in Epoxy Composite for Enhanced Performance
Authors: Padhan Meghashree , Marathe Umesh , Bijwe Jayashree
Published: November 2022

The current study focuses on studying the effect of reinforcement of carbon fabric (CF) decorated with in-situ grown silver (Ag) nanoparticles (NPs) on the performance properties of epoxy composite. The Ag NPs were grown on carbon fabric by reducing silver nitrate. The main objective of developing such an innovative reinforcement was to improve thermal conductivity, interlaminar strength, and tribological properties of CF-epoxy composites. The growth of NPs on the surface of CF was confirmed through scanning electron microscopy (SEM), energy dispersive X-Ray spectroscopy (EDAS), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction studies. The development of composites was conducted by the impregnation method, followed by compression molding. It was observed that in-situ growth of Ag NPs enhanced thermal conductivity by 40%, enhanced inter-laminar shear strength by 70%, enhanced wear resistance by 95%, and reduced the friction coefficient by 35% in comparison to untreated CF.
The Role of Nitrogen-Doped TiO2 Supported by Platinum Catalyst Synthesized via Various Mode Preparations for Photocatalytic Enhancement
Authors: Natar Nadiah , Ghani Nureel , Hamzah Siti , Rosli Muhammad , Muhamad Nur , Azami Mohammad , Ishak Mohd , Razak Sharin , Nawawi Wan
Published: November 2022

The limitations of TiO2 as a photocatalyst such as the larger bandgap energy, which only activates under the UV region, give a lower photocatalytic activity. This study reports the role of the N and Pt co-dopant on the modification of the TiO2 photocatalyst for photocatalytic degradation of methylene blue dye under different mode preparations, i.e., sequential and vice-versa modes. The sequential mode preparation of the N and Pt co-dopant TiO2 photocatalyst consisted of the initial preparation of the N-doped TiO2 (N-TiO2) under the calcination method, which was then further doped with platinum (Pt) through the photodeposition process labeled as NPseq-TiO2, while the vice-versa mode was labeled as PNrev-TiO2. About 1.58 wt.% of N element was found in the NPseq-TiO2 photocatalyst, while there was no presence of N element detected in PNrev-TiO2, confirmed through an elemental analyzer (CHNS-O) and (EDX) analysis. The optimum weight percentage of Pt for both modes was detected at about ±2.0 wt.%, which was confirmed by inductively coupled plasma-emission spectroscopy (ICP-OES). The photoactivity under methylene blue (MB) dye degradation of the NPseq-TiO2 photocatalyst was 2 and 1.5 times faster compared to the unmodified TiO2 and PNrev-TiO2, where the photodegradation rates were, ca., 0.065 min−1 and 0.078 min−1, respectively. This was due to the N elements being incorporated with the TiO2 lattice, which was proven by UV-Vis/DRS where the bandgap energy of NPseq-TiO2 was reduced from 3.2 eV to 2.9 eV. In addition, the N generated a stronger PL signal due to the formation of oxygen vacancies defects on the surface of the NPseq-TiO2 photocatalyst. The higher specific surface area as well as higher pore volume for the NPseq-TiO2 photocatalyst enhanced its photocatalytic activity. Moreover, the NPseq-TiO2 showed the lowest COD value, and it was completely mineralized after 7 h of light irradiation. The preparation order did not affect the Pt dopant but did for the N element. Therefore, it is significant to investigate different mode preparations of the N and Pt co-dopant for the modification of TiO2 to produce a good-quality photocatalyst for photocatalytic study under the photodegradation of MB dye.
The Association between Body Weight Misclassification in Adolescence and Body Fat and Waist Circumference in Adulthood: A Longitudinal Study
Authors: Aloufi Abdulaziz D. , Najman Jake M. , Mamun Abdullah A.
Published: November 2022

This study examined the longitudinal association between adolescent body weight misclassifications and body fat and waist circumference during adulthood. A sample was derived from a large Australian birth cohort study. The data analyses were restricted to 1002 participants for whom data on both measured and perceived weight at a 14-year follow-up and the actual measure of adult body fat and waist circumference at a 30-year follow-up were available. To determine misclassifications, we compared the perceived weight with the measured weight. The results were presented as means and mean differences (with a 95% confidence interval) of the body fat percentages and waist circumference levels across the weight misclassification groups, adjusting for potential covariates. For both male and female adolescents, weight underestimation was significantly associated with an increase in body fat percentages and waist circumference in adulthood as compared to those who correctly estimated their weight. In the mean difference analyses, adolescent males and females who underestimated their weight were found to have significantly higher body fat, and waist circumference means than those who correctly estimated their weight in the unadjusted and adjusted comparisons. The adolescent males who overestimated their weight had higher body fat, and waist circumference means when they reached adulthood. Increased awareness of weight misclassification and actual weight among adolescents might contribute to better control of weight gain in adulthood.
Most Plant-Based Milk Alternatives in the USDA Branded Food Products Database Do Not Meet Proposed Nutrient Standards or Score Well on Nutrient Density Metrics
Authors: Drewnowski Adam
Published: November 2022

Plant-based milk alternatives and plant-based waters are of variable nutritional value. The present objective was to assess nutrient density of all plant-based beverages in the US Department of Agriculture Branded Food Products Database and determine whether plant-based milk alternatives met the proposed nutrient standards. Plant-based milk alternatives (n = 1042) were identified as almond, soy, coconut, cashew, other tree nut, flax/hemp, pea, and oat, quinoa, and rice products. Plant-based waters (n = 550) were coconut, aloe, tree, fruit, and plain. Machine searches of ingredient lists identified products with added sugars, salt, vitamins, and minerals. Plant-based milk alternatives were tested for compliance with previously developed nutrient standards. The Nutrient Rich Food Index (NRF5.3), two versions of Nutri-Score, and Choices International were the nutrient density metrics. Plant-based milk alternatives had mean energy density of 49 kcal/100 g, were low in protein (~1.1 g/100 g), often contained added sugars and salt, and tended to be fortified with calcium, vitamin A, vitamin D, and vitamin B12. Only 117 milk alternatives (11.2%) met nutrient standards and only 80 (7.7%) met the more stringent “best of class” standards for ≥2.8 g/100 g protein and <3.1 g/100 g added sugars. The latter were mostly soy milks. Nutri-Score grades varied depending on whether the beverages were treated as beverages or as solid foods, as is currently required. The highest NRF5.3 scores were given to soy, almond, and tree nut milk alternatives. Plant-based waters had low energy density (~23 kcal/100 g), contained added sugars (4.6 g/100 g), and some had added vitamin C. Applying nutrient standards to plant-based milk alternatives can aid new product development, promote more transparent labeling, and inform potential regulatory actions. Guidance on minimum protein content, maximum recommended amounts of fat, added sugars, and sodium, and consistent fortification patterns would be of value to regulatory agencies and to the food industry.
Advances in Fucoxanthin Research for the Prevention and Treatment of Inflammation-Related Diseases
Authors: Guan Biyun , Chen Kunsen , Tong Zhiyong , Chen Long , Chen Qi , Su Jingqian
Published: November 2022

Owing to its unique structure and properties, fucoxanthin (FX), a carotenoid, has attracted significant attention. There have been numerous studies that demonstrate FX’s anti-inflammatory, antioxidant, antitumor, and anti-obesity properties against inflammation-related diseases. There is no consensus, however, regarding the molecular mechanisms underlying this phenomenon. In this review, we summarize the potential health benefits of FX in inflammatory-related diseases, from the perspective of animal and cellular experiments, to provide insights for future research on FX. Previous work in our lab has demonstrated that FX remarkably decreased LPS-induced inflammation and improved survival in septic mice. Further investigation of the activity of FX against a wide range of diseases will require new approaches to uncover its molecular mechanism. This review will provide an outline of the current state of knowledge regarding FX application in the clinical setting and suggest future directions to implement FX as a therapeutic ingredient in pharmaceutical sciences in order to develop it into a treatment strategy against inflammation-associated disorders.
Nutraceutical Approaches to Dyslipidaemia: The Main Formulative Issues Preventing Efficacy
Authors: Colletti Alessandro , Fratter Andrea , Pellizzato Marzia , Cravotto Giancarlo
Published: November 2022

Currently, the nutraceutical approach to treat dyslipidaemia is increasing in use, and in many cases is used by physicians as the first choice in the treatment of patients with borderline values. Nutraceuticals represent an excellent opportunity to treat the preliminary conditions not yet showing the pathological signs of dyslipidaemia. Their general safety, the patient’s confidence, the convincing proof of efficacy and the reasonable costs prompted the market of new preparations. Despite this premise, many nutraceutical products are poorly formulated and do not meet the minimum requirements to ensure efficacy in normalizing blood lipid profiles, promoting cardiovascular protection, and normalizing disorders of glycemic metabolism. In this context, bioaccessibility and bioavailability of the active compounds is a crucial issue. Little attention is paid to the proper formulations needed to improve the overall bioavailability of the active molecules. According to these data, many products prove to be insufficient to ensure full enteric absorption. The present review analysed the literature in the field of nutraceuticals for the treatment of dyslipidemia, focusing on resveratrol, red yeast rice, berberine, and plant sterols, which are among the nutraceuticals with the greatest formulation problems, highlighting bioavailability and the most suitable formulations.
Combined Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat of Metabolic Disease: A Review
Authors: Zhang Li , Liu Yuan , Sun Ying , Zhang Xin
Published: November 2022

Background: Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive research suggests that diet alongside physical exercise interventions exert beneficial effects on metabolic diseases by regulating gut microbiota, involving in the changes of the energy metabolism, immune regulation, and the microbial-derived metabolites. Objective: In this review, we present the latest evidence in the modulating role of diet and physical exercise in the gut microbiota and its relevance to metabolic diseases. We also summarize the research from animal and human studies on improving metabolic diseases through diet-plus-exercise interventions, and new targeted therapies that might provide a better understanding of the potential mechanisms. Methods: A systematic and comprehensive literature search was performed in PubMed/Medline and Web of Science in October 2022. The key terms used in the searches included “combined physical exercise and diet”, “physical exercise, diet and gut microbiota”, “physical exercise, diet and metabolic diseases” and “physical exercise, diet, gut microbiota and metabolic diseases”. Conclusions: Combined physical exercise and diet offer a more efficient approach for preventing metabolic diseases via the modification of gut microbiota, abating the burden related to longevity.
The Effects of Walnuts and Academic Stress on Mental Health, General Well-Being and the Gut Microbiota in a Sample of University Students: A Randomised Clinical Trial
Authors: Herselman Mauritz F. , Bailey Sheree , Deo Permal , Zhou Xin-Fu , Gunn Kate M. , Bobrovskaya Larisa
Published: November 2022

Poorer mental health is common in undergraduate students due to academic stress. An interplay between stress and diet exists, with stress influencing food choices. Nutritional interventions may be effective in preventing mental health decline due to complex bidirectional interactions between the brain, the gut and the gut microbiota. Previous studies have shown walnut consumption has a positive effect on mental health. Here, using a randomized clinical trial (Australian New Zealand Clinical Trials Registry, #ACTRN12619000972123), we aimed to investigate the effects of academic stress and daily walnut consumption in university students on mental health, biochemical markers of general health, and the gut microbiota. We found academic stress had a negative impact on self-reported mood and mental health status, while daily walnut consumption improved mental health indicators and protected against some of the negative effects of academic stress on metabolic and stress biomarkers. Academic stress was associated with lower gut microbial diversity in females, which was improved by walnut consumption. The effects of academic stress or walnut consumption in male participants could not be established due to small numbers of participants. Thus, walnut consumption may have a protective effect against some of the negative impacts of academic stress, however sex-dependent mechanisms require further study.
Novel CYP11A1-Derived Vitamin D and Lumisterol Biometabolites for the Management of COVID-19
Authors: Qayyum Shariq , Slominski Radomir M. , Raman Chander , Slominski Andrzej T.
Published: November 2022

Vitamin D deficiency is associated with a higher risk of SARS-CoV-2 infection and poor outcomes of the COVID-19 disease. However, a satisfactory mechanism explaining the vitamin D protective effects is missing. Based on the anti-inflammatory and anti-oxidative properties of classical and novel (CYP11A1-derived) vitamin D and lumisterol hydroxymetabolites, we have proposed that they would attenuate the self-amplifying damage in lungs and other organs through mechanisms initiated by interactions with corresponding nuclear receptors. These include the VDR mediated inhibition of NFκβ, inverse agonism on RORγ and the inhibition of ROS through activation of NRF2-dependent pathways. In addition, the non-receptor mediated actions of vitamin D and related lumisterol hydroxymetabolites would include interactions with the active sites of SARS-CoV-2 transcription machinery enzymes (Mpro;main protease and RdRp;RNA dependent RNA polymerase). Furthermore, these metabolites could interfere with the binding of SARS-CoV-2 RBD with ACE2 by interacting with ACE2 and TMPRSS2. These interactions can cause the conformational and dynamical motion changes in TMPRSS2, which would affect TMPRSS2 to prime SARS-CoV-2 spike proteins. Therefore, novel, CYP11A1-derived, active forms of vitamin D and lumisterol can restrain COVID-19 through both nuclear receptor-dependent and independent mechanisms, which identify them as excellent candidates for antiviral drug research and for the educated use of their precursors as nutrients or supplements in the prevention and attenuation of the COVID-19 disease.
Malnutrition Defined by Geriatric Nutritional Risk Index Predicts Outcomes in Severe Stroke Patients: A Propensity Score-Matched Analysis
Authors: Chen Ying , Yang Xinguang , Zhu Yingying , Zhang Xiaoni , Ni Jingxian , Li Yi
Published: November 2022

Background: Malnutrition’s prognostic impact in patients with severe stroke requiring ICU admission is not well known. This study aimed to assess the nutritional status of severe stroke patients using the geriatric nutritional risk index (GNRI) and examine the association of GNRI with mortality in that population. Methods: We identified 1145 severe stroke patients requiring ICU admission from the Medical Information Mart for Intensive Care (MIMIC-III) database and divided them into low GNRI (≤98) or high GNRI (>98) groups. We used a propensity score matching (PSM) method to reduce confounding. Cox proportional hazards regression and restricted cubic splines were used to elucidate the association between GNRI and mortality. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated. Results: A total of 397 (35%) patients were in the low GNRI group (at risk of malnutrition). After PSM, patients in the low GNRI group still suffered higher mortality compared with the high GNRI group at 28 days (27.9 vs. 20.8%), 90 days (35.5 vs. 25.7%), and 1 year (43.4 vs. 30.9%) (p < 0.05). A low GNRI was significantly associated with an increased mortality (HR: 1.38, 95% CI 1.03–1.86 in 28 days; HR: 1.45, 95% CI 1.11–1.89 in 90 days; HR: 1.51, 95% CI 1.19–1.92 in 1 year). Sensitivity analyses yielded consistent results. Restricted cubic splines showed a progressively decreasing risk of mortality with increasing GNRI scores up to 110, approximately. Conclusion: Severe stroke patients with malnutrition experienced an increased risk of death compared to those without malnutrition. GNRI, as a simple and practical nutritional screening tool, can be used as a routine approach to the nutritional status of stroke patients.
Rye Bread Crust as an Inducer of Antioxidant Genes and Suppressor of NF-κB Pathway In Vivo
Authors: Wächter Kristin , Gohde Birte , Szabó Gábor , Simm Andreas
Published: November 2022

Heat-processed food, like bread, containing high amounts of advanced glycation end products (AGEs), is controversially discussed regarding the effects on health and disease. In in vitro and in vivo experiments, AGEs can induce proinflammatory NF-κB and/or the anti-inflammatory NRF2 pathways. The aim of this study was to investigate how gene expression is influenced in vivo upon short as well as long-term feeding of mice with control and bread crust-food (BC). For that, the liver, kidney and heart from two days- and eight days-fed mice were isolated and gene arrays were performed. Fewer genes were affected in terms of expression after two days of BC feeding than after eight days. We observed, especially in the heart and to lesser extent in the liver, an induction of antioxidant response by BC. Among the significantly up-regulated genes identified in the heart were transcripts encoding for cardioprotective and antioxidative proteins like metallothionein 2, uncoupling protein 3 and pyruvate dehydrogenase kinase 4. In contrast, in the liver, genes encoding for inflammatory drivers like thioredoxin-interacting protein, lncRNA Mtss1 and ubiquitin-specific protease 2 were down-modulated. However, an increased expression of immunoglobulins was observed in the kidney. Furthermore, in vivo imaging analyses with NF-κB-luciferase-reporter mice uncovered a rather anti-inflammatory response, especially after three and seven days of the feeding study. Our results suggest that bread crust exerts antioxidant and anti-inflammatory effects in the model organism mouse in an organ-specific manner.
Effects of Smoking on the Gut Microbiota in Individuals with Type 2 Diabetes Mellitus
Authors: Kondo Yuriko , Hashimoto Yoshitaka , Hamaguchi Masahide , Kaji Ayumi , Sakai Ryosuke , Inoue Ryo , Kashiwagi Saori , Mizushima Katsura , Uchiyama Kazuhiko , Takagi Tomohisa , Naito Yuji , Fukui Michiaki
Published: November 2022

Smoking affects eating habits; however, few studies on smoking and the gut microbiota have reported the effects of diet in detail. This cross-sectional study aimed to determine the association between smoking and the gut microbiota, considering the impact of smoking on dietary intake. Dietary habits and the composition of the gut microbiota were assessed in 195 men with type 2 diabetes (164 non-current smokers and 31 current smokers) using a brief self-administered diet history questionnaire and 16S ribosomal RNA gene sequencing of fecal samples. The data were compared according to the current smoking status of the participants. Current smokers had high alcohol and sugar/sweetener intake and low fruit intake. The proportion of the Coprococcus genus was higher among current smokers. Multiple regression analysis adjusted for current smoking, age, exercise habits, alcohol intake, sugar and sweetener intake, and fruit intake showed that smoking was associated with the proportion of the Coprococcus genus. Current smoking was associated with both dietary intake and composition of the gut microbiota. Although dietary intake should be considered when investigating the association between smoking and the gut microbiota, the results suggest that the direct effect of smoking is more significant.
Hydroxysafflor Yellow A Phytosomes Administered via Intervaginal Space Injection Ameliorate Pulmonary Fibrosis in Mice
Authors: Li Tingting , Han Dong , Li Zhongxian , Qiu Mengqi , Zhu Yuting , Li Kai , Xiang Jiawei , Sun Huizhen , Shi Yahong , Yan Tun , Shi Xiaoli , Zhang Qiang
Published: November 2022

Idiopathic pulmonary fibrosis is a fatal interstitial disease characterized by fibroblast proliferation and differentiation and abnormal accumulation of extracellular matrix, with high mortality and an increasing annual incidence. Since few drugs are available for the treatment of pulmonary fibrosis, there is an urgent need for high-efficiency therapeutic drugs and treatment methods to reduce the mortality associated with pulmonary fibrosis. The interstitium, a highly efficient transportation system that pervades the body, plays an important role in the occurrence and development of disease, and can be used as a new route for disease diagnosis and treatment. In this study, we evaluated the administration of hydroxysafflor yellow A phytosomes via intervaginal space injection (ISI) as an anti-pulmonary fibrosis treatment. Our results show that this therapeutic strategy blocked the activation of p38 protein in the MAPK-p38 signaling pathway and inhibited the expression of Smad3 protein in the TGF-β/Smad signaling pathway, thereby reducing secretion of related inflammatory factors, deposition of collagen in the lungs of mice, and destruction of the alveolar structure. Use of ISI in the treatment of pulmonary fibrosis provides a potential novel therapeutic modality for the disease.