bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on the Influence of Core Stability on the Coring Process of Long-Barrel Coring Tools
Authors: Liu Jiliang , Sun Jinsheng , Jiang Guancheng , Yu Yongjin
Published: December 2024

In the process of long-barrel coring, the improper selection of operating parameters can easily cause blocked deformation, violent vibration of the core, core fracture, and impact crushing, which lead to a reduction in the stability of the core and core harvesting rates. Accurate knowledge of the influence of relevant factors on core stability is the key to improving core harvesting rates. Therefore, in this study, a numerical calculation model for tight and fractured cores in a barrel was constructed based on the Drucker–Prager criterion, using the finite element method. A numerical calculation model of a core broken into a barrel was constructed using the discrete element method. A study was conducted on the influence law of core stability under different core lengths, rotational speeds, weights on bit, and well inclination angles. The influence of each factor on core stability was analysed based on the vibration displacement and stress distribution characteristics of the core. The calculations show that increasing the weight on bit and reducing the rotation speed can effectively reduce the radial vibration displacement and local stress in tight and fractured cores, reduce the possibility of core fracture or breakage, and improve core stability. When the well inclination angle is large, it can easily cause core deformation and wall sliding, generating large contact stress and radial vibration displacement, significantly reducing the core stability. A broken core has the worst stability and is easily compacted in the core barrel, producing secondary crushing and plugging effects. Increasing the core barrel length resulted in a more unstable core. Compared with single-barrel coring, the distortion of the core column under double-barrel coring was more evident. In addition, the coring process, cuttings distribution, and drill bit hydraulic characteristics were studied based on the CFD-DPM method. The conclusions of this study are of great significance for optimising coring operation parameters to further improve core stability and coring harvest rate.
On the Emergence of the Castellieri Settlements and Possible Effects of Climatic Changes in the 2nd Millennium BC in the Adriatic Region
Authors: Hellmuth Kramberger Anja
Published: December 2024

The fortified hilltop settlement of Monkodonja, located near Rovinj on the west coast of Istria, Croatia, provides insight into Bronze Age occupation and conflict in the Adriatic region. Established around 2000 BC, as evidenced by a series of C14 dates from human and animal bones, the settlement experienced significant construction phases, particularly in its defensive architecture. Its earliest fortifications, built with limestone blocks using dry-stone wall techniques, date to the 19th century BC, with major expansions in the 16th century BC, where the primary wall was doubled in width and reached over 3 m in thickness. Monkodonja’s architectural complexity, notably the West Gate and Acropolis fortifications, and certain types of artifacts reveal influences from southern regions such the eastern Aegean. However, the settlement appears to have met a violent end around the 15th century BC, suggested by destruction layers, widespread burning, and the presence of weapons such as a lance tip, bronze axe, and slingstones. Monkodonja’s destruction raises questions about broader military conflicts in the Adriatic region during this period. Possible causes could include localized warfare or connections to larger-scale disturbances. Research in Monkodonja is also significant in the context of the debate surrounding the emergence of the so-called Castellieri settlements in Istria at the beginning of the 2nd millennium BC. As early as the beginning of the 20th century, it was proposed that a migration of people to the Istrian peninsula brought this new settlement form and other influences, leading to a significant population increase. The appearance of the Castellieri settlement form coincides with a period marked by documented climatic changes and two major natural disasters in the form of volcanic eruptions.
Dynamic Dysregulation of Ribosomal Protein Genes in Mouse Brain Stress Models
Authors: Sharma Vandana , Shukla Rammohan
Published: December 2024

Emphasizing their evolutionarily conserved role in stress adaptation mechanisms, ribosomal protein genes (RPGs) are observed to be downregulated in various stressors and across phyla. However, this evolutionarily conserved stress response is not well explored in mouse models of neurobiological stress. This study investigates the dysregulation patterns of RPGs in various murine preclinical stress paradigms across different brain regions using available transcriptomic data and identifies the non-canonical ribosomal functions using synaptic gene-ontology terms. Without a discernible structure across different brain areas, we observed heterogeneous dysregulation, encompassing either up or downregulation in both cytoplasmic and mitochondrial RPGs. However, downregulation was more prominent than upregulation, and the overall dysregulation seems more prevalent in the chronic stress paradigm compared to stress paradigms involving acute and early-life stress. Enrichment analysis significantly associates dysregulated RPGs with post-synaptic gene ontology terms, emphasizing their involvement in synaptic modulation. Overall, the study demonstrates ribosomal dysregulation as an evolutionarily conserved stress response mechanism during different mouse stress paradigms. We discuss the possibility that the variability in the directionality of dysregulation may emerge as a potential marker of neuronal activity in response to diverse stress paradigms and the involvement of paradigm-specific RPG dysregulation either in the process of global downscaling of ribosome biogenesis or in the process of ribosomal heterogeneity, each leading to a different effect.
Прогрессирующая мультифокальная лейкоэнцефалопатия в практике врача-невролога: современные представления, клинический случай
Authors: Лурье Т.В. , Дрик О.Н. , Воронцова Ж.В.
Published: December 2024

Прогрессирующая мультифокальная лейкоэнцефалопатия – прогрессирующее фатальное демиелинизирующее заболевание центральной нервной системы, вызванное реактивацией существующего в латентном состоянии JC-вируса на фоне выраженного иммунодефицита. В то же время в ряде случаев развитие заболевания происходит и при отсутствии тяжелого иммунодефицита. Диагноз прогрессирующей мультифокальной лейкоэнцефалопатии основывается на определении JC-вирусной ДНК методом полимеразной цепной реакции в цереброспинальной жидкости (чувствительность 64–90%, специфичность 100%) и данных магнитно-резонансной томографии головного мозга. Стандартом диагностики считается гистологическое исследование биоптата головного мозга. Специфическое лечение прогрессирующей мультифокальной лейкоэнцефалопатии не разработано. При развитии данной патологии целесообразно отменить или максимально снизить дозу глюкокортикоидов и цитотоксических препаратов. В большинстве случаев заболевание приводит к летальному исходу в течение нескольких месяцев. Представлен клинический случай иммунокомпетентного пациента с установленным диагнозом прогрессирующей мультифокальной лейкоэнцефалопатии. Данное клиническое наблюдение подтверждает сложность диагностики данного заболевания в связи с отсутствием выраженности симптоматики, которая неспецифична, а также с необходимостью подтверждения диагноза дополнительными методами (инструментальными, лабораторным), не всегда доступными в повседневной практике.

Progressive multifocal leukoencephalopathy is a progressive fatal demyelinating disease of the central nervous system caused by reactivation of the latent JC-virus against the background of severe immunodeficiency. However, in some cases, the disease may also occur with no severe immunodeficiency. The diagnosis of progressive multifocal leukoencephalopathy is based on the determination of JC-viral DNA by polymerase chain reaction in cerebrospinal fluid (sensitivity 64–90%, specificity 100%) and data from magnetic resonance imaging of the brain. A histological examination of brain biopsy specimen is considered the diagnostic standard. No specific treatment for progressive multifocal leukoencephalopathy has been established. In this pathology, it is advisable to withdraw or minimize glucocorticoids and cytotoxic medicinal products dosage. In most cases, the disease is fatal within a few months. A case report of an immunocompetent patient with diagnosed progressive multifocal leukoencephalopathy is presented. This clinical observation confirms the diagnostic challenge for this disease due to the lack of symptom severity which are nonspecific, as well as the need for additional methods (instrumental and laboratory) to confirm the diagnosis, which are not always available in routine practice.
Гипофизит с проявлениями гипопитуитаризма у пациента с ВИЧ-инфекцией и раком предстательной железы: клинический случай
Authors: Мохорт Т.В. , Лихорад Н.М. , Даниленко Д.А. , Мохорт Е.Г. , Дурдыгылыджова Д.
Published: December 2024

Гипофизит включает в себя широкий спектр воспалительных заболеваний, которые приводят к увеличению размеров гипофиза и синдрому компрессии. Это состояние является редкой причиной гипопитуитаризма, патогенез которого до сих пор плохо изучен. Распространенность гипофизита составляет 1 случай на 1 миллион человек. Распознавание новых причин, более широкое использование методов визуализации, а также увеличение количества патологических образцов после операции на гипофизе привели к увеличению заболеваемости гипофизитом. Полифакторность развития гипофизита приобретает особую актуальность в связи с лекарственными, вирусными и соматическими влияниями. Представленное клиническое наблюдение пациента с гипофизитом, развившимся после спленэктомии на фоне ВИЧ-инфекции и метастазирующего рака предстательной железы, оставляет широкое поле для дискуссии по выделению основного этиологического агента. Гипопитуитаризм на фоне гипофизита является состоянием, требующим адекватной заместительной терапии, так как наличие эндокринных дисфункций, особенно надпочечниковой недостаточности, оказывает негативное влияние на качество жизни пациента и определяет высокие риски в стрессовых ситуациях.

Hypophysitis includes a wide range of inflammatory diseases leading to increased pituitary gland size and compression syndrome. This condition is a rare cause of hypopituitarism, the pathogenesis of which is still poorly understood. The incidence of hypophysitis is 1 case per 1 million people. Recognizing new causes, more extensive use of imaging techniques, and increased number of pathological specimens after pituitary surgery have led to an increase in hypophysitis diagnoses. The multifactorial nature of hypophysitis becomes of particular relevance due to medicinal, viral, and somatic impacts. The presented clinical case of a patient with hypophysitis occurring after splenectomy against HIV infection and metastatic prostate cancer leaves a wide field for discussion aimed at identifying the main etiologic agent. Hypopituitarism on the background of hypophysitis is a condition requiring adequate replacement therapy, since endocrine dysfunctions, especially adrenal insufficiency, impact negatively patients’ quality of life and determine high risks in stressful situations.
Pädiatrische Palliative Care – Wo stehen wir? Wohin geht es?
Authors: Bergsträsser Eva , Streuli Jürg C.
Published: December 2024

Palliative Care für Kinder und Jugendliche hat sich in Ländern mit einem gut entwickelten Gesundheitswesen etabliert. Noch steht das Angebot jedoch bei weitem nicht allen Kindern und deren Familien, die davon profitieren könnten, zur Verfügung – in der Schweiz erreichen wir knapp 10% der Kinder mit palliativem Behandlungsbedarf.
Symptomkontrolle in der pädiatrischen Palliative Care – Wissenswertes und Hilfreiches
Authors: Süess Erika , Ogal Mercedes , Bender Hans-Ulrich , Bergsträsser Eva
Published: December 2024

Die Behandlung von belastenden Symptomen stellt einen Grundbaustein der pädiatrischen Palliative Care (PPC) dar. In diesem Artikel werden einige der häufigsten belastenden Symptome und deren Therapiemöglichkeiten vorgestellt.
Annonce d’un pronostic grave chez l’adolescent : enjeux juridiques et éthiques
Authors: Le Bourgeois Fleur , Lipp Alexandra , Jürgen Jox Ralf , Droz-Sauthier Gaëlle
Published: December 2024

James est un adolescent de 14 ans, suivi par l’équipe d’oncologie pédiatrique d’un centre hospitalier universitaire depuis 3 ans pour une tumeur cérébrale. Au diagnostic, cette tumeur était de bas grade, et pour limiter son évolution, il a reçu plusieurs traitements oncologiques (radiothérapie et chimiothérapie). Il bénéficie d’un suivi clinico-radiologique régulier.
La maladie et la mort dans le système familial : aspects assécurologiques et psychosociaux de la consultation sociale
Authors: Tschudi Nora , Fronterotta Linda
Published: December 2024

Le diagnostic d'une maladie limitant la vie d'un enfant confronte la famille à des défis inattendus. Du jour au lendemain leur quotidien est bouleversé et il n'est pas rare que les parents doivent renoncer à leurs projets de vie. Cela exige de la part des familles des capacités d'adaptation considérables, ainsi que des ressources personnelles, matérielles et sociales. Les enfants nécessitant des soins palliatifs représentent non seulement un défi pour les professionnels mais aussi, et surtout, pour les parents et les frères et sœurs.
Verification and validation for KCS total resistance
Authors: Popa Florentin-Daniel , Neacșu Nicoleta Elena , Bosoancă Radu , Bilea-Pricop Andreea
Published: December 2024

This study presents CFD simulations of the KCS model ship, focusing on ship resistance, free-surface behavior, and predictions of sinkage and trim at a Froude number of 0.26. Reynolds-Averaged Navier-Stokes (RANS) equations are solved using the k-ω SST turbulence model. Verification and validation are carried out through a generalized Richardson Extrapolation method, following Stern et al. [1] methodology. Results are compared with experimental data for total resistance coefficient, sinkage, trim, and wave patterns.
Engine power limitation (EPL) to comply with EEXI requirements. study on an LPG tanker
Authors: Costache Adrian , Bosoancă Radu
Published: December 2024

The study analyses the Energy Efficiency Existing Ship Index (EEXI), a regulation introduced by the International Maritime Organization (IMO) to enhance energy efficiency in maritime transport and reduce greenhouse gas emissions. Focusing on a semi-refrigerated LPG tanker, the research explores compliance strategies, including engine power limitation (EPL). The reduction of engine power by 24% resulted in a decrease in ship speed, meeting EEXI requirements with minimal impact on performance. Additionally, ship manoeuvrability was assessed through turning circle simulations before and after EPL. The findings confirmed that the vessel’s manoeuvrability remains within IMO standards, ensuring both efficiency and operational safety.
About antifouling solutions to protect ship’s hull
Authors: Maimon Aurel-Dan
Published: December 2024

Antifouling solutions are essential for protecting ship hulls from marine organisms like algae, barnacles, and molluscs, which can slow down the ship and increase fuel consumption. They are crucial for maintaining a ship's efficiency and longevity by protecting the hull from marine growth, which can slow the vessel and increase fuel consumption. Modern antifouling methods, such as specialized paints, copper-based coatings, self-polishing surfaces, silicone coatings, ultrasonic systems, and electrolytic solutions, offer effective ways to combat biofouling. These solutions not only improve operational performance but also contribute to environmental sustainability by reducing the need for frequent cleaning and minimizing the release of harmful biocides into the water. The ongoing development of innovative antifouling technologies will continue to enhance the protection and efficiency of maritime vessels.
ESTUDO SOBRE A DISPONIBILIDADE DE INFRAESTRUTURA URBANA E EQUIPAMENTOS PÚBLICOS NO BAIRRO LINDOLFO PIRES, EM NAZAREZINHO-PB
Authors: Nunes Sombra Andre , Valentim Afonso Filipe , Thiago Moreira Cavacalcanti Francisco , Ferreira Costa André
Published: December 2024

Introdução: Os aspectos socioeconômicos e o panorama histórico do perfil urbano das cidades brasileiras, não é difícil de compreender os agravamentos da desigualdade social existente e a real necessidade da presença do poder público junto aos problemas da sociedade nas cidades brasileira. Logo, haja vista a pertinência de compreender que um planejamento urbano ou plano diretor existente, no que se referem aos equipamentos urbanos públicos e privados, infraestrutura e serviços prestados, ordenando e requalificando as melhorarias na qualidade de vida são pertinentes ante ao direito subjetivo assegurado à população, considerando, assim, os aspectos de acessibilidade, mobilidade urbana, serviços públicos prestados e moradia digna das pessoas nas cidades. Objetivo: Averiguar a disponibilidade ou ausência de infraestrutura e equipamentos urbanos públicos e privados no Bairro Lindolfo Pires, na cidade de Nazarezinho-PB, percebendo a importância desse aparato urbanístico para a população que reside nesse conjunto habitacional, e a sua função socioeconômica, e os impactos no desenvolvimento local. Metodologia: Este Trabalho trata-se de um estudo de caso de forma exploratória, com coleta de dados primária do objeto de estudo. Tivemos como base a análise das informações levantadas mediante dados fotográficos e de observação da infraestrutura e equipamentos urbanos. Resultado: Como resultado, teve como referência a coleta de dados in loco, verificando se existem ou não as especificações de infraestrutura e equipamentos elencados e seus condicionantes legais. Conclusão: Como desfecho, conclui-se que o conjunto habitacional Lindolfo Pires, mediante o que foi averiguado, há a presença de equipamentos urbanos e infraestrutura básica, porém apontando a necessidade de melhorias nesses equipamentos e serviços básicos.

PALAVRAS-CHAVE: Cidade. Equipamentos públicos. Infraestrutura urbana.
A APLICAÇÃO DO CANABIDIOL COMO ALTERNATIVA TERAPÊUTICA PARA A MELHORA DA QUALIDADE DE VIDA DE IDOSOS PORTADORES DE DORES CRÔNICAS: UMA REVISÃO SISTEMÁTICA DE LITERATURA
Authors: Caroline de Araújo Teotônio Ana , Amanda Mota Seabra Cícera
Published: December 2024

Introdução: A Cannabis sativa tem sido estudada por seus potenciais efeitos terapêuticos, especialmente o canabidiol (CBD), no tratamento de dores crônicas em idosos. Com o envelhecimento populacional crescente no Brasil, o manejo de doenças crônicas, em especial a dor, tornou-se um desafio significativo para a saúde pública. A dor crônica, muitas vezes associada a distúrbios musculoesqueléticos, pode afetar a qualidade de vida de idosos de maneira significativa. O uso de cannabis, particularmente o CBD, tem mostrado promissores benefícios no alívio da dor, como efeito anti-inflamatório e neuroprotetor, e pode ajudar na redução do uso de opioides, uma classe medicamentosa convencional com diversos efeitos adversos. Esse estudo visa avaliar como o CBD pode contribuir para o alívio da dor persistente, além de explorar seus benefícios adicionais na saúde e bem-estar dos idosos. Método: trata-se de uma revisão de artigos publicados entre 2020 e 2024 para avaliar a eficácia do canabidiol no manejo da dor crônica em idosos. A busca resultou em 50 artigos no SCIELO, 500 no Google Acadêmico e 60 na BVS, dos quais sete foram selecionados por atenderem aos critérios de inclusão. Resultados: O CBD pode reduzir significativamente a intensidade da dor e melhorar a qualidade de vida, com menor uso de opioides. Embora ainda haja debates sobre os efeitos colaterais e a segurança do uso prolongado, os estudos analisados sugerem que o CBD representa uma alternativa terapêutica viável e segura, especialmente para idosos. Conclusão: O canabidiol mostrou-se eficaz no controle da dor crônica, com benefícios claros para a qualidade de vida dos pacientes. No entanto, mais estudos clínicos são necessários para aprofundar o entendimento dos mecanismos de ação e confirmar a segurança a longo prazo. A utilização de cannabis medicinal, incluindo o CBD, emerge como uma opção promissora para substituir ou complementar os tratamentos tradicionais, especialmente em idosos, melhorando o manejo da dor e o bem-estar geral.

Palavras-chaves: Cannabis sativa. Canabidiol. Dor crônica. Idosos. Revisão sistemática.
ATUACÃO FISIOTERAPÊUTICA NO PÓS-OPERATÓRIO IMEDIATO DE CIRURGIA BARIÁTRICA: UMA REVISÃO DE LITERATURA
Authors: VIVIANE SILVA LEITE JOSEFA , BRAGA ROLIM VIEIRA RENATA , JORGE DIAS MICHEL , CRISTIAN ALVES DE SOUSA KENNEDY
Published: December 2024

Introdução: Obesidade é o acumulo excessivo de gordura corporal. A cirurgia bariátrica tem como intuito auxiliar na perda de peso. A fisioterapia atua no pós-operatório prevenindo as complicações, e ajudando no processo de recuperação. Objetivo: Apresentar a relevância da intervenção fisioterapêutica no pós-operatório imediato de pacientes que foram submetidos à cirurgia bariátrica. Métodos: Trata-se de uma revisão integrativa da literatura, com busca nas bases de dados PubMed, SciELO, Google Acadêmico e SBCBM, a partir das palavras-chave Cirurgia bariátrica, Obesidade e Fisioterapia. Foram incluídos artigos originais publicados entre 2009 a 2024. Foram estabelecidos com critérios de inclusão: literaturas completas, gratuitas e disponíveis eletronicamente, nas línguas inglesa e portuguesa. Foram estabelecidos com critério de exclusão: literaturas duplicadas, monografias, resumos e com acesso restrito à página. Resultados: A pesquisa é composta por 4 artigos, as condutas fisioterapêuticas utilizadas foram a VNI, através do CPAP, exercícios respiratórios e exercícios de baixa intensidade. Considerações finais: As condutas apresentadas mostraram ótimos resultados na prevenção de complicações pulmonares em pacientes no pós-operatório de cirurgia bariátrica.

Palavras-chave: Cirurgia bariátrica; Obesidade; Fisioterapia.
ESTRATÉGIAS PARA ELABORAÇÃO DE AMBIENTES ACADÊMICOS PARA ESTUDANTES DE ARQUITETURA COM AUXÍLIO DA NEUROARQUITETURA
Authors: Alencar Sousa Yasmin , Valentim Afonso Filipe , Bella Sarmento Salgueiro Eliziário Matias Emanoella , Goldfarb de Oliveira Marina
Published: December 2024

O aumento no número de pessoas com transtornos mentais tem gerado crescente preocupação em diversas áreas de estudo, incluindo a Neuroarquitetura. Pesquisadores descobriram que o ambiente pode afetar diretamente a qualidade de vida do usuário, influenciando seu bem-estar e sua vivência nos espaços. Dessa forma, a combinação entre arquitetura e neurociência torna-se uma ferramenta para desenvolver projetos que ofereçam soluções inovadoras, capazes de criar espaços que promovam o bem-estar, a aprendizagem e a produtividade. Ao considerar o impacto do ambiente acadêmico na vida dos estudantes de arquitetura, o artigo busca apontar estratégias fundamentadas na neuroarquitetura, para melhorar esses espaços de aprendizagem, com base em estudos e exemplos práticos. Diante desse cenário, inicialmente, foi realizado um levantamento bibliográfico, seguido de uma análise de correlatos; foram selecionados os projetos do Edifício da Faculdade de Arquitetura e Design da Universidade de Melbourne e do Instituto de Neurociências Wi Tsai, que serviram como base para a definição das estratégias projetuais empregadas. Nesse contexto, busca-se enfatizar a importância de ambientes que incentivem o bem-estar, a criatividade e a flexibilidade, permitindo que docentes e estudantes explorem o ambiente acadêmico de maneira mais favorável. Os resultados indicam que ambientes acadêmicos podem ser projetados de forma a reduzir o estresse, aumentar o engajamento e melhorar a experiência acadêmica. Para isso, estratégias projetuais como a integração de elementos naturais, o uso de móveis ajustáveis e confortáveis, o controle de temperatura, ventilação e níveis de ruído, entre outros, podem ser aplicados. Concluímos que a neuroarquitetura se apresenta como uma ferramenta avançada para otimizar os espaços de aprendizagem.

Palavras-chave: Neuroarquitetura; Saúde mental; Ambiente acadêmico; Bem-estar.
Formulation, Evaluation and Market Comparison of Herbal AntiDandruff Shampoo
Authors: Goswami Priyanka , Lokhande Tushar , Vohra Payaam , Khan Mahek , Anam Syed Anam Syed , Yadav Kajal
Published: December 2024

Shampooisoneofthemostcommonformsofhaircleans
erhavebeenused forcleansing
thescalp.Thepurposeofusingshampooistoremovedirt
thatisbuiltuponthehairwithouttaking
outmuchofthesebum.Inthepresentscenario,synthetic
shampoohasadversesideeffectslike dryness of hair
and keratin loss on the
scalpsotheincorporationofherbal botanicals to
formulate herbal shampoo could prove to be a
forthcoming
alternative.Itseemsimprobablethatherbalshampoo,
although better in performance and safer than
synthetic ones, will be popular with
consumers.Thestudyaimedtoformulateaherbinfusedshampoo by using natural ingredients like
(Sapindus mukorossi, Azadirachta indica,
Trigonella foenum-graecum,Hibiscus rosa-sinensis,
Cocos nucifera) base, and
preservativesandtoevaluateandcompare its
physicochemical properties with the marketed
herbal shampoos.In the current paper we have
formulated, characterized and performed a market
comparison of our herbal creambased shampoo and
the results showed favorable organoleptic
characteristics cleansing action, dispersity and
foaming ability.
A Review Study – Effect of Millets on Glucose level and Cholesterol level in Type 2 Diabetes Mellitus Patients
Authors: Srivastava Sangyanshi , Kumar Ayush , Negi Sachin
Published: December 2024

From the past few decades, the dietary modification
in the treatment of a different diseases which
indicates the physiological response to a food.
However, the present study was reviewed
systemically and it was found in the different
studies that the daily consumption of different
types of millet-based foods may reduce the risk of
various disease such as Diabetes particularly TypeII, cardiovascular and so on. Even in few studies it
was found that the Korean proso millet also
elevates the HDL level along with effect on
controlling glucose level. It can be concluded that
millets play a vital role in management of type II
diabetes, CVD and in various non-communicable
diseases.
Detection of Adulterants in Several Food Commodities
Authors: George Ajula Achamma , Jose Achsha Mary , Adityabhaskar K V Adityabhaskar K V , Vivek V S Vivek V S , Abhiram Hari Abhiram Hari
Published: December 2024

Food is one of the most essential and
basic needs of all living beings. The objective of
this study is to observe adulterants in commonly
used food items. A right amount of food provides
energy to survive, to do physical activity and to
build body strength. Food without any adulteration
such as addition of any unwanted chemical and
substitution of nutritional quality is the need of all
human beings. But with the developing world,
adulteration with food has become very common by
adding harmful chemicals to preserve food for
longer periods or by removing or reducing the
quality of food to gain profit. Such type of
adulteration causes severe life threatening diseases.
Knowing about such causes, many food companies
still do adulteration and sell the product in market in
the name of good quality and put consumers life in
danger just to gain profit. In our study to detect
adulteration in food items several chemical tests
were performed.
Exploring the Pharmaceutical Potential of Colored Wheat: Insights into Nutritional Quality and Health Benefits
Authors: Awasthi Saumya
Published: December 2024

Colored wheat, known for its dynamic red, blue,
purple, and black tones, is wealthy in bioactive
compounds like anthocyanins, phenolic acids, and
flavonoids, which offer critical wellbeing benefits.
These compounds give powerful antioxidant, antiinflammatory, and anti-carcinogenic properties,
situating colored wheat as a promising useful
nourishment with pharmaceutical potential.The
enhanced nutritional profile of colored wheat,
which incorporates tall levels of dietary fiber, basic
minerals, and vitamins. These nutrients contribute
to progressed cardiovascular health, superior
glycemic control, and improved intestine health,
making colored wheat especially useful in avoiding
and overseeing incessant maladies like
cardiovascular disorders, diabetes, and certain
cancers.Despite these benefits, challenges remain
in completely realizing colored wheat’s
pharmaceutical applications, such as optimizing
bioactive compound extraction and conducting
large-scale clinical trials. All things considered,
colored wheat holds extraordinary guarantee as a
nutraceutical, offering unused roads for health
advancement and disease avoidance.
XXX
Authors: T.Manjula* T.Manjula* , Adhithiyan L.Dhanush , M. Krishnamoorthy M. Krishnamoorthy , C.Navayugan C.Navayugan , R.Padhmanathan R.Padhmanathan
Published: December 2024

Herbal soap is a natural soap to conventional soap
that is Often made using herbs and plant-based
ingredients. The use of herbal soap provides
various benefits, such as healing the skin, provide
natural fragrance, provide Smoothing; it is made
using natural ingredients that do not harm The
environment and is biodegradable numerous
chemical toxins and microorganisms present in the
atmosphere may cause chemical infection and
damage to the skin cosmetics alone are not
sufficient to take care of the skin. Herbal soap
ingredients use neem, tulsi, and turmeric, neem leaf
and seed were found effective against
dermatophytes, turmeric shows anti-inflammatory
and anti-bacterial properties and tulsi shows anti
viral activity. Herbal soap preparations are
medicines or pharmaceuticals because they include
antibacterial and antifungal agent.Herbal soaps are
also effective in curing different skin problems.
These soaps also contain glycerin, which is
generally not used in marketable soaps.
Effect of Pharmacist Intervention on Knowledge, Attitude and Practice Regarding Nutrition and Supplements in Antenatalwomen in Tertiary Health Care Center in North Kerala, India
Authors: Kumar Aparnna S , C Shareena K Safa Sherin , Jereena E Jereena E , T Shenoy Heera
Published: December 2024

Pregnancy is a condition that
requires extra attention. The goal of the study is to
keep the mother and baby healthy throughout and
after pregnancy. Since after being pregnant, the
body's needs and requirements will change
substantially. An important factor in the mother's
and fetus healthy wellness is nutrition and
supplements. Iron deficiency is the most common
cause of anemia in pregnancy .
METHODS: A prospective interventional study
conducted for assessing pregnant women KAP on
nutrition and supplements and prevalence of
anemia .Approval from an Institutional ethics
committee (IEC) obtained for this study. During the
study, pregnant women at 1st & 2nd trimester
presenting for ANC visits ,who are willing to
participate in this study will be included Informed
consent will be obtained from each participant prior
to the study beginning. A pre-designed and pretested questionnaire is used to collect dat data
during their pre-test .The questionnaire have 3
sections . There will be 5 questions designed to
assess the knowledge level of pregnant women .
Meanwhile questionnaire includes 6 question to
assess the attitude and 7 questions to assess dietary
practice of pregnant women .Intervention of
pharmacist will be done using the patient
information leaflet at the first visit. Post test is
scheduled after 12 weeks to pretest to assess the
efficacy of the same Pretest and post test data will
be compared and analysis done .From the
observations recorded, the given objectives will be
assessed and evaluated using suitable statistical
techniques .RESULT: The study included 126
participants .Only a small portion of pregnant
women have a positive KAP towards nutrition and
supplements. From our study, Prima gravida (36%)
had a higher frequency of anemia in pregnant
women than multigravida (25.6%). Prevalence of
anemia found to be in our study population at
50.4%.
A Literature Review on Aamavata with Special Refrence to Rheumatoid Arthritis
Authors: Aware Dr. Milind , Pawar Dr. Aishwarya
Published: December 2024

According to Ayurveda, Agni
performs a first-rate position in preserving the
equilibrium of the body, the impairment of which
ends up within side the formation of Ama. So, any
factors either dietary, environmental or
psychological which causes impairment of Agni
become responsible for the formation of Ama also.
The Ama is a causative factor for many diseases
including Aamavata. It is disease of Rasavaha
strotasa. Aamavata can be correlated to Rheumatoid
Arthritis based on the similarities in clinical
manifestation. Rheumatoid Arthritis
Evaluating Risk Factors for Urinary Tract Infections in Postmenopausal Women: Insights and Implications
Authors: Nishana Fathima , Anupama V.R Anupama V.R , Shifas C Muhammad , Sareena A Sareena A , Reeta James Reeta James
Published: December 2024

Background: Urinary tract infections (UTIs) are a
significant health concern among older women,
particularly due to anatomical differences and
hormonal changes associated with aging.
Postmenopausal women are particularly vulnerable,
experiencing higher susceptibility to recurrent
UTIs.
Objectives: This study aimed to identify risk
factors for recurrent UTIs in postmenopausal
women and evaluate the organisms responsible for
causing urinary tract infections (UTIs).
Methods: A prospective observational study was
conducted at KMCT Hospital from December 2022
to May 2023; involving 91 postmenopausal women
aged 40 to 75 with clinically suspected UTIs.
Ethical approval was obtained, and participants
provided informed consent. Urine specimens were
collected using the mid-stream "clean-catch"
technique, with infection defined by bacterial
counts exceeding 10^5 CFU/mL. Data on medical
history, sexual activity, and urinary habits were
collected through a standardized questionnaire.
Results: The study population predominantly
consisted of older women, with 39.56% over 70
years. Risk factors identified included diabetes
(72.52%), incontinence (61.5%), and a history of
UTIs (41.75%). E. coli was the most common
pathogen (48.3%), followed by Klebsiella species
(19.8%). Findings were consistent with existing
literature indicating a correlation between diabetes,
urologic abnormalities, and UTI risk.
Discussion: The results highlight the multifactorial
nature of UTI risk in postmenopausal women,
emphasizing the need for targeted prevention
strategies and careful management of recurrent
infections to mitigate antibiotic resistance.
Diarrhoea Explained: Classification by Pathophysiology and Drug-Induced Mechanism
Authors: Namburu Sreelakshmi , Nakka Ramya , Perwala Madhavi , Naik Arkprabha
Published: December 2024

Diarrhoea is a more prevalent and multifaceted
medical condition affecting individuals worldwide.
This review aims to elucidate the diverse spectrum
of diarrhoea, covering its myriad causes, underlying
physiological mechanisms, and the role of druginduced factors in its pathogenesis. Understanding
the underlying mechanisms of diarrhoea, such as
osmotic, secretory, inflammatory, and fatty
diarrhoea, is crucial for effective management.
Osmotic diarrhoea results from unabsorbable
solutes, while secretory diarrhoea involves
excessive fluid secretion by the bowel mucosa.
Inflammatory diarrhoea involves damage to the
intestinal lining, often triggered by infections or
autoimmune reactions. Fatty diarrhoea, or
steatorrhea, stems from malabsorption of fats.
Additionally, numerous drugs can induce diarrhoea
through various mechanisms, necessitating careful
consideration in clinical practice. This review
attempts to provide insights into the complicated
terrain of diarrhea and attempts to enlighten the
various paths of causative agents and mechanisms of
induction of various diarrhoea.
Synthesis and Anti-Tubercular Activity of Quinazoline Derivatives
Authors: Sreelakshmi S Sreelakshmi S , Dr. A Sumathy Dr. A Sumathy , Greeshma S Greeshma S , Dr. N L Gowrishankar Dr. N L Gowrishankar
Published: December 2024

A series of [2-phenyl-3-[(E)-(1-
phenyl ethylidene)amino]quinazolin-4(3H)-one]
derivatives have been synthesized with the starting
material as 2-amino benzoic acid. The final
compounds were synthesized using different
ketones like acetophenone, p-methyl acetophenone,
4-methoxy acetophenone, m-hydroxy
acetophenone, 3-amino acetophenone. The
compounds were tested for Antitubercular activity
and shows comparable activity with the standard
drugs.
Advanced Nutraceuticals for the Treatment of Various Diseases
Authors: Hindu.N Hindu.N , Basha P B Shameer , Lakshmi T.Sravana
Published: December 2024

The growing popularity of nutraceuticals is driven
by consumer demand for natural and effective
alternatives that offer physiological benefits and
disease prevention. Plant-based extracts, rich in
bioactive compounds such as lipids,
phytochemicals, and pigments, are increasingly
used in the food, pharmaceutical, and cosmetic
industries. Traditional extraction methods like
Soxhlet extraction are time-consuming and solventintensive. As a result, there is a rising demand for
more efficient extraction techniques that reduce
time, solvent usage, and environmental impact.
Modern methods such as ultrasound-assisted
extraction, microwave-assisted extraction,
supercritical fluid extraction, and accelerated
solvent extraction have been developed to address
these challenges, offering faster and more
sustainable ways to obtain valuable plant-derived
compounds. These innovations support the growth
of nutraceuticals, nutritional therapy, and
phytotherapy, contributing to improved health and
reduced healthcare costs.
Intranasal Drug Delivery: Novel Delivery Route for Effective Management of Neurological Disorder
Authors: D. Vetrivel D. Vetrivel , Dr. K.B. Ilango Dr. K.B. Ilango , K. Ambiga K. Ambiga , P. Padmavathi P. Padmavathi , J. Selvaganapathi J. Selvaganapathi , E. Tamilarasan E. Tamilarasan , L. Yahavi L. Yahavi
Published: December 2024

Neurological disorders, such as Alzheimer’s
disease, Parkinson’s disease, and epilepsy, pose
significant challenges in treatment due to the
blood-brainbarrier (BBB), which restricts drug
delivery to the brain. The BBB’s selective
permeability hinders the efficacy of systemically
administered drugs, leading to inadequate treatment
outcomes and significant side effects. This paper
provides a comprehensive review of innovative
delivery routes that bypass or cross the BBB,
enabling direct delivery of therapeutics to the brain.
Function of Ayurveda in the Prevention and Intervention of Timir
Authors: Khairnar Vd. Shita , Deshmukh Vd. Anil
Published: December 2024

In Ayurveda, visual disturbances are referred to as
Timira, Kacha, and Linganasha. Timira is an eye
disease that starts with Avyaktya Darshana and
goes all the way to complete blindness. There are
no independent etiological factors present in
Timira's eye. Sushruta describes Timira as Ghora
Roga, which results in visual disturbances because
Doshas build up in different eye Patalas. Timira is a
Drusti Mandala disorder that, if left untreated,
progresses from vision impairment to complete
blindness. The world over is investigating
alternative medical systems to prevent surgical
complications and preventative ophthalmology to
preserve and enhance vision. In this situation,
having a thorough understanding of the Timira is
critical for appropriate management of the illness.
While considering the sign and symptoms it can be
correlated with Cataract, Myopia, Keratoconus etc.
regarding similarity with modern; different author
has different opinions. A review of Timira from
several sources has been compiled here, with a
focus on cataract and myopia
Understanding the Therapeutic Role of Diet in Ayurveda: A Comprehensive Perspective on Health and Nutrition
Authors: Bhandari Dr Ankita
Published: December 2024

Ayurveda is an ancient science. Of
all the Ayurvedic concepts, Trayopastambha is the
most important since it is based on three principles:
Brahmacharya (Celibacy), Nidra (Sleep), and
Ahara (Diet). These three pillars determine one's
lifespan and level of enjoyment. Ahara secured the
top spot in the Trayopastambha. Thus, we need to
be familiar with the Ayurvedic Ahara (diet). Eating
a non-wholesome diet can cause illness, but
following a healthy diet plan can help you stay
well. Power, radiance, and Oja are given to the
body by ahara; it also boosts mental fortitude and is
necessary for longevity. Dravyabhuta Aushadhi is a
category that includes AharaDravyas. Therefore,
for Vikaraprasamana, the dietary guidelines can be
regarded as Upaya or Adravyabhuta Aushadhi. The
eight dietary components known as "Ahara Vidhi
VisheshaAyatanani" are thought to be responsible
for both health and sickness. Ahara is regarded as
considered the superior medicine, Maha
bhaishajya. Inadequate eating and lifestyle choices
lead to a host of lifestyle disorders and diseases that
can be avoided with appropriate Ahara and eating
practices. Ayurveda maintains that the individual's
Prakriti, or constitution, should be taken into
consideration when selecting an Ahara. The
purpose of this article is to examine the
significance of the ahara as aushadha.
Formulation of Herbal Pain Relief Turmeric Balm
Authors: Ganesh Zarekar , Pathan V.A Pathan V.A , Sayyed Dr.Gaffar , Garje Dr.sanjay
Published: December 2024

Turmeric is a mild digestive, being aromatic, a
stimulant and a carminative Turmeric is one of
Nature‟s most powerful healers. The active
ingredient in turmeric is curcumin. Tumeric has
been used for over 2500 years in India, where it
was most likely first used as a dye.
The medicinal Properties of this spice have been
slowly revealing themselves over the centuries.
Long known For its anti-inflammatory properties,
recent research has revealed that turmeric is a
natural Wonder, proving beneficial in the treatment
of many different health conditions from cancer to
Alzheimer‟s disease. An ointment base on the spice
is used as an antiseptic in India.
Turmeric Water is an Asian cosmetic applied to
impart a golden glow to the complexion. Curcumin
has Been shown to be active against Staphlococcus
aureus (pus-producing infections). Anemia, Cancer,
diabetes, digestion, food poisoning, gallstones,
indigestion, IBS, parasites, poor Circulation, staph
infections, and wounds. Turmeric decreases Kapha
and so is used to remove Mucus in the throat,
watery discharges like leucorrhea, and any pus in
the eyes, ears, or in Wounds, etc.
In Unani medicine, turmeric has been used for
conditions such as liver obstruction And jaundice
and has been applied externally for ulcers and
inflammation. Roasted turmeric has Been used as
an ingredient of a preparation used for dysentery.
Turmeric has also been used in Tooth powder or
paste. Turmeric has been used for many conditions
in traditional medicine in India, Pakistan and
Bangladesh.
The rhizome is generally the part of the plant that is
most widely Used. It can be prepared in various
ways and is reputed to alleviate asthma and coughs.
Hot water extracts of the dried rhizome have been
taken orally in Ayurvedic medicine to reduce
Inflammation. Turmeric is also regarded as a
„rasayana‟ herb, which is a branch of Ayurvedic
Medicine. Here turmeric is used to counteract
ageing processes.
Artificial Intelligence in Drug Discovery and Drug Design
Authors: Narkhede Jagruti
Published: December 2024

Overthepasttenyears,artificialintelligencehasrevolut
ionisedthefieldofdrugresearch. The process for
discovering new drugs could be
completelytransformed by artificial intelligence,
which could provide increased speed, accuracy, and
efficiency. The process for discovering new drugs
could be completely transformed by artificial
intelligence, which could provide increased speed,
accuracy, and efficiency. Numerous uses of
artificial intelligence, including virtual screening
and drug design, have been employed in drug
development. AI methods are brokendown into
learning paradigms and modelarchitectures. The
surveyed publications are arranged
chronologicallyto illustratethe evolution ofAI
indrug discoveryover time in terms of technical
advancement. We anticipate that this survey offers
an in-depth examination of artificial intelligence in
drug discovery. This development is being
motivated, among other things, by the increasing
use of machine learning, and specifically deep
learning, in many scientific domains and by
advancements in computer hardware and software.
Medicinal chemistry has benefited from the
beginning scepticism that has begun to fade over
the use of AI in pharmaceutical development. A
number of methodological advancements,
including hybrid de novo design, message-passing
models, spatial symmetry-preserving networks, and
other cutting-edge machine learning paradigms, are
probably going to become standard
practicesandaidinansweringsomeofthetrickiestprobl
ems.Thecreationofmodelsandopen data sharing will
be essential to the advancement of drug discovery
using AI. There is a
growingpotentialforthediscoveryofseveralnovelmed
icationsasaresultoftheadvancement of artificial
intelligence in the pharmaceutical sector. Human
illness rates are rising dramatically, but there
areveryfew medications available
totreatorcurethem. However, the
pharmaceuticalindustry'sandartificialintelligence'sc
ombinedeffortswillpreventthissortof situation in the
future by accelerating the discovery of medications
with better clinical outcomes. AI-based drug
development techniques are being used by several
pharmaceutical companies to treat a variety of
illnesses, including diabetes, Parkinson's disease,
Alzheimer's disease, OCD, and more Technology
may significantlyassist in resolving a number of
issues and limitations with the conventional drug
development process.
A comprehensive review on Sebastianiachamaelea (L). Muell.arg
Authors: BS Indu BS Indu , S Sooraj S Sooraj
Published: December 2024

Medicinal plants have played a vital
role in healthcare across cultures for centuries,
providing a rich source of remedies for various
ailments. Traditional medicine heavily relies on
medicinal plants, and many communities
worldwide have cultivated a deep understanding of
their uses. Ayurveda the ancient system of medicine
from India also uses natural remedies including
herbs, diet and lifestyle changes, to prevent and
treat illness. Plants are fundamental in Ayurveda,
providing the basis of its treatments and remedies.
Thousands of plants are mentioned in Ayurvedic
classics. Among them, many are not available now
or have not been properly identified for their
botanical sources. At the same time, many plants
regionally available are effectively used by
traditional vaidyasfor treating various conditions.
Such plants have to be analyzed for their
introduction into mainstream clinical usage. The
foundation for developing new drugs from plants
lies in selecting, organizing and systematically
evaluating plant products based on their various
therapeutic uses in traditional medical systems.
One such plant is Sebastianiachamaelea (L).
Muell.arg belongs to Euphorbiaceae family which
is called as Kodiyavanakku in Malayalam. This
study was conducted to provide a comprehensive
review of the drug using classical and
contemporary literature.
Pharmacogenomics and Personalized Medicine
Authors: Jagtap Mr. Bipin M , S.Parkhe Mr.Vaibhav , Kawade Mr. Rushikesh B , K.Sayyed Mr. Afnanuddin
Published: December 2024

Pharmacogenomics, a field that
combines pharmacology and genomics, is a
cornerstone of personalized medicine. It aims to
tailor drug therapies based on an individual’s
genetic makeup to optimize efficacy and minimize
adverse effects. This review explores the historical
development of pharmacogenomics, its underlying
mechanisms, current applications, challenges,
advantages, and disadvantages. By leveraging
genetic information, personalized medicine seeks
to shift healthcare from a generalized to a patientspecific approach. Despite its promise, there are
significant obstacles in terms of clinical
implementation, regulatory hurdles, and ethical
considerations. The future of pharmacogenomics
lies in overcoming these barriers to make
personalized medicine a mainstream healthcare
practice.