bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure, Function and Regulation of Lipoprotein(a)
Authors: Koschinsky Marlys L. , Ramharack Randy
Published: September 2022

Lipoprotein(a) (Lp(a)) is a focus of intensive investigation owing to the correlation that has been demonstrated between elevated plasma Lp(a) levels and the development of a variety of atherosclerotic disorders. The Lp(a) particle resembles LDL and contains apolipoprotein(a) and apolipoproteinB-100 linked by a single disulfide bond. Apolipoprotein(a), which distinguishes Lp(a) from low density lipoprotein both immunologically and biochemically, shares a high level of sequence similarity with the fibrinolytic proenzyme plasminogen. The similarity between the two molecules has
prompted speculation that Lp(a) exerts is pathogenic effects by interfering with the normal functions of plasmin(ogen). This has been demonstrated in a number of studies which show that Lp(a) interferes with the tPA­ mediated activation of plasminogen. This, in tum, has been found to result in the decreased lysis of fibrin clots and in the reduced cleavage of TGF- and subsequent increased proliferation of smooth muscle cells. The demonstrated localization of Lp(a) in the arterial intima (likely mediated by its extensive interactions with extracellular matrix components) may also facilitate its oxidation and subsequent clearance via the macrophage scavenger receptor, thereby contributing to foam cell formation. Lp(a) can bind to glycosaminoglycans and proteoglycans; these complexes are also ligands for the scavenger receptor. Lp(a) studies have been generally complicated by the high degree of heterogeneity that is associated with the plasma-derived molecule. For example, there are over 35 different apo(a) isoforms, which differ based on the number of identically-repeated plasminogen kringle IV-like sequences in the gene. Additionally, Lp(a) is heterogeneous in its ability to bind to lysine, and likely in its degree of glycosylation, as well as in the apolipoprotein content of the particle. Lp(a) levels are also highly variable in the population. While the mechanism(s) which govern plasma Lp(a) levels are currently unknown, there is evidence to suggest that Lp(a) levels are regulated at the levels of synthesis rather than catabolism. Although Lp(a) levels are genetically determined to a large degree, recent evidence suggests that plasma levels can be modulated by a variety of hormones and pharmacological agents.
Helminthosporiosis Impact on the Photosynthetic Apparatus and the Oxydative Status of Barley Seedlings at Different Stages of Development
Authors: Kаbashnikova Liudmila F. , Savchenko Galina E. , Abramchik Larisa M. , Domanskaya Irina N. , Viks Tatsiana N. , Pashkevich Lyubov V. , Pilipovich Tatsiana S. , Daubniuk Yuliya N. , Shpileuski Sviataslau N. , Martysiuk Hanna V.
Published: September 2022

Background:

In recent years, spot blotch, a disease caused by Bipolaris sorokiniana (Sacc.) Shoem., has emerged as a serious concern with regard to spring barley cultivation. However, the effect of this pathogen on the photosynthetic apparatus and oxidative status of barley plants at different stages of chloroplast development has hardly been studied.

Aims / Methods:

The study aimed to evaluate the photosynthetic apparatus and protective system of a spring barley’s (Hordeum vulgare L.) response to Bipolaris sorokiniana (Sacc.) Shoem. (B.S.) at different stages of chloroplast biogenesis. The green seedlings of different ages (3-11 days) were treated with fungal spores (106 spores×ml−l). The first leaves of seedlings were analyzed 24 or 48 hours after the inoculation with the pathogen.

Results:

Differences in response to fungal infection were identified in leaf tissues containing chloroplasts at different stages of development. The differences manifested themselves in the non-photochemical quenching (NPQ) of absorbed energy, the total content of reactive oxygen species (ROS), lipid peroxidation (LPO) activity and polyphenol content. An increase in peroxidase (POX) activity in infected barley seedlings at the anabolic stage of chloroplast biogenesis and its decrease at the catabolic stage against the background of a constant increase in ascorbate peroxidase (APX) activity were revealed. A high positive correlation between the chlorophyll and malondialdehyde content (MDA) was observed.

Conclusion:

In barley seedlings of different ages, a response to fungal contamination is different in the PS II activity, the general content of ROS and polyphenols, as well as the LPO activity. The photosynthetic and oxidative parameters of barley plants may be a useful tool to control plant immunity in view of breeding and novel protective technologies.
The Ambulance Location Can Influence Emergency Medical Service Response Time: A Literature Review
Authors: Sanjana I Wayan Edi , Wihastuti Titin Andri , Muslihah Nurul
Published: September 2022

Factor of the accident was the highest cause of mortality. The mortality or death caused by accident could be avoided through a fast and appropriate first aid. The ambulance was a component of EMS that must reach the incident location in a quick time. This research was aimed to identify the effects of ambulance station location and ambulance response time. In the literature review, four databases were used as EBSCOhost, Proquest, Science Direct, and SpringerLink and through access help from Brawijaya University library. PRISMA method was exerted in this research to select the articles and choose as many as 15 research articles that fulfill inclusion criteria. The response time of EMS was very influential for patient care and safety. The standby ambulance location can affect the officer's response time. The determination of the ambulance location for the EMS service provider was very significant to offer an optimal service.
Psychoanalytic Conceptualization of Archetypes
Authors: Mohammed Araz Ahmed
Published: September 2022

This study proposes a psychoanalytic reading of Kit Anderson’s Five Sisters: A Modern Novel of Kurdish Women based on Carl Gustav Jung’s (1875-1961) major theories of archetypes which are the persona, the shadow, and the self discussed in Structure and Dynamics of the Psyche. While hospitality, honor killings, political persecution and resistance are displayed in the novel as general archetypal images that are used to label Kurds with, Anderson’s primary purpose in crafting characters, themes, and settings is the universal nature of suffering. The five sisters are engulfed by horrendous conditions, which produce a wide range of causes that push the novelist to exhibit various forms of the persona, the realization of the shadow, and the (dis)integration of the self. In order to create a world where  the self prevails, the novel proposes two prospects: the dismantlement of tribal mentality and the liberation of women through education. The implication is that although Anderson presents a village in which clan mentality rules, the novel altogether is a plane that needs a pilot and runaway lights on either side to work through and to land.
A Trans Youth of Color Study to Measure Health and Wellness: Protocol for a Longitudinal Observation Study
Authors: Calvetti Sam , Rusow Joshua A , Lewis Jacqueline , Martinez Amarah , Slay Lindsay , Bray Bethany C , Goldbach Jeremy T , Kipke Michele D
Published: September 2022

Background

Growing research on transgender youth is accounting for the variety of ways in which young people define their genders and sexualities. Because of this growing representation, more research is needed to understand how intersectional identities and stigma affect risk for HIV acquisition along the HIV care continuum and engagement in mental and physical health care. Little is known about accessibility to HIV-related prevention services of nonbinary and transmasculine youth, and further understanding of the impacts on transfeminine people—those who have historically faced the highest prevalence of HIV positivity—is crucial.

Objective

The overarching aims of the Trans Youth of Color Study are to conduct longitudinal research with a cohort of transgender minority youth (TGMY), explore factors that aid in the prevention of new HIV infection and transmission, and reduce HIV- and AIDS-related disparities by focusing on successful engagement in care. Findings from this research will be used to inform the development of new interventions designed to engage TGMY in the HIV prevention and care continua.

Methods

Longitudinal research (baseline and follow-up assessments every 6 months for 3 waves of data collection) followed a cohort (N=108) of transgender youth of color recruited in Los Angeles, California, United States. Participants were recruited using multiple community-informed strategies, such as from local venues, social media, and participant referral. In addition to self-report surveys, urine was collected to assess recent use of illicit drugs, and blood, rectal, and throat swabs were collected to test for current sexually transmitted infection and HIV infection. Additional blood and plasma samples (10 mL for 4 aliquots and 1 pellet) were collected and stored for future research.

Results

Participants in the Trans Youth of Color Study were recruited between May 25, 2018, and December 7, 2018. Baseline and longitudinal data are being analyzed as of August 2022.

Conclusions

The findings from this research will inform adaptations to existing evidence-based HIV prevention interventions and help to guide new interventions designed to engage TGMY, especially those who are Black, Indigenous, or people of color, in the HIV prevention and care continua.

International Registered Report Identifier (IRRID)

DERR1-10.2196/39207
Consequências de saber pouco e saber errado para a democracia
Authors: Brandes de Azevedo Ferreira Luiza
Published: September 2022

Voters' political knowledge is one of the central aspects of a democracy, since it is related to their ability to make good political choices. However, being poorly informed or being ignorant about facts of reality is different from being misinformed, or having biased and wrong information about reality. The objective of this work is to discuss the possible consequences of these two phenomena for democracy. From the analysis of the bibliography on the subject, it is possible to conclude that, on the one hand, the lack of information from voters, although extensively proven, does not allow, by itself, to infer that the quality of democracy would be compromised by it, in addition to being issue more easily mitigated by the expansion of information as occurs in electoral periods. Misinformation, on the other hand, seems to have more harmful consequences, when the information seized by voters is wrong, it is not enough to increase the quantity and reduce the cost of information, it is also necessary to have the possibility of correction, which seems more difficult given the greater resistance of the voters to suppress or correct erroneous information that appeals to their preferences rather than simply adding new information.
Fake News Detection Using Deep Learning
Authors: Khan Nazakat Farooq , Gupta Ankur
Published: September 2022

Abstract: Social media news may be a double-edged sword. There are a number of benefits to utilizing it: It's simple to use, takes little time, and is user-friendly. It's also simple to share socially significant data with others. On the other hand, a number of social networking sites adapt the news based on personal opinions and interests. This sort of misinformation is spread over social media with the intent of causing harm to a person, organization, or institution. Because of the prevalence of fake news, computer tools are needed to detect it. Fake news detection aims to aid users in spotting various sorts of fake news. We can tell if the news is genuine or created if we have encountered fake or authentic news before. We may use a number of models to understand social media news. This is a donation in two ways. We must first give datasets containing both fake and accurate news and conduct multiple experiments before developing a false news detector. Various machine learning techniques are used to categorize the data. Random Forest, Logistic Regression, Naives Bayes, Gradient Boost and Decision Tree techniques are used and compared. It was found that Gradient Boost has the best accuracy.
Document Automation Using Artificial Intelligence
Authors: Bhatt Ajay
Published: September 2022

Abstract: Documents such as Invoices, receipts, bills, ID cards, and passports are basic and very common documents around the world which are used for accounting, tax records, payments, financial history, performing activities like data analytics, digitizing company’s records etc. All these documents are available in different formats such as images, PDFs and hard copies (paper). To retrieve the data from these documents, a person needs to manually write or type the data from documents to the table, which is time-consuming as well as irritating. We provide a simple, unique and easily implementable end-to-end approach that uses AI and Deep Learning models to automate the above tasks by just uploading the document of any format image, PDF or Docs, and the software will extract the data and save it in the required structural format. Our approach eliminates the need to manually enter data in an Excel or database record with no limit on the amount of work while companies are facing problems because of their limited workforce and limited work hour for manual data entry, but our software can run 24x7.
O discurso político midiático sob a lente da Semiolinguística: análise de um vídeo do Presidente Jair Bolsonaro no YouTube
Authors: Freitas Ernani Cesar de , Schiffl Farina Luciane , Boaventura Luis Henrique
Published: September 2022

O objetivo deste estudo é demonstrar como se estabelece o contrato de comunicação do discurso político em um vídeo publicado no YouTube pelo Presidente da República Jair Bolsonaro em setembro de 2020; o vídeo atualizava as informações sobre o programa assistencial Bolsa Família. A análise configura-se na perspectiva semiolinguística da Análise do Discurso, desenvolvida por Patrick Charaudeau (2010, 2013, 2020). Esta pesquisa classifica-se como descritiva e bibliográfica com abordagem qualitativa. Como resultado da análise do corpus, verificamos que o sujeito enunciador (EUe) utiliza pistas situacionais e estratégias discursivas para persuadir o espectador da veracidade do seu depoimento populista.
Mulheres Estagiárias em Jornalismo: análise a partir da perspectiva interseccional
Authors: Campos Évilin , Grohmann Rafael
Published: September 2022

Este artigo apresenta articulações teórico-metodológicas empreendidas a partir da perspectiva interseccional para investigar as negociações profissionais de cinco estagiárias em jornalismo no Rio Grande do Sul, que se inscrevem nos marcadores sociais da diferença de gênero, raça e classe. Com isso em vista, colhemos pistas sobre as estratégias de estudantes mulheres para a ascensão da carreira, que, em síntese, se relaciona à obtenção massiva de experiências, realização de cursos extracurriculares e demasiado empenho em sustentar suas habilidades. Tais táticas de crescimento profissional associamos ao agenciamento de feminilidade, que acaba por reter o desenvolvimento das mulheres às margens das profissões e salários.
Manejo de cárie radicular: um guia para o dentista brasileiro baseado na tradução e adaptação cultural do consenso internacional/ORCA E EFCD
Authors: Endres Bruna Leis , De Oliveira Rayanne Lisboa , Barbosa Cecília de Brito , Ferreira Fábio Luiz , Ciancio Christina Carol Mary , Lia Erica Negrini , Hilgert Leandro Augusto , Garcia Fernanda Cristina Pimentel , Almeida Júlio César Franco , Takeshita Eliana Mitsue , Damé-Teixeira Nailê
Published: September 2022

Objetivo: A cárie radicular é um problema da Odontologia moderna, porém é notável a falta de diretrizes sobre o seu manejo. Objetivamos elaborar e adaptar um guia a partir da tradução das recomendações do consenso internacional European Organization for Caries Research (ORCA) e European Federation of Conservative Dentistry (EFCD) para as tomadas de decisão clínica na intervenção do processo de cárie na pessoa idosa, com foco na cárie radicular. Materiais e métodos: O protocolo de tradução das recomendações do consenso internacional consistiu nas etapas: (1) tradução inicial, (2) síntese da tradução, (3) retradução, (4) revisão por comitê de especialistas, com adaptação cultural. A partir da tradução, foi desenvolvido um guia com diretrizes para tratamento de cárie radicular no Brasil. Resultados: Para prevenção de novas lesões é recomendada a escovação diária com dentifrício >1.500ppm/F. Dentifrícios com 5.000ppm/F ou vernizes (>20.000ppm/F) podem ser indicados para paralisar lesões radiculares ativas e para prevenção em pessoas idosas com alta suscetibilidade à cárie radicular, e o Diamino Fluoreto de Prata (>30%) para paralisar lesões ativas. Intervenções invasivas diretas são indicadas dependendo da situação clínica. Discussão: Nota-se uma falta de interesse em estudos primários sobre tratamentos para cárie radicular, criando assim uma lacuna em relação ao seu manejo, que reflete no nível de evidência detectado pelo consenso. Conclusão: Guias clínicos são importantes para reduzir a lacuna entre a pesquisa e a prática clínica. Essa tradução para o português facilitará o acesso dos dentistas brasileiros em relação a evidência consolidada até o momento para o manejo de cárie radicular.
#Clareamentoalaser: características das postagens em português no Instagram®
Authors: Francisco Gustavo Silva , Farinha Barbara Martins , Bernardes Eduardo Magalhães Dias Guido , Noronha Luiza Gioda , Carvalho Nathalia Leonarski , Correa Stella Parada Santos Gallo , Sartori Leticia Regina Morello , Nachtigall Fôlha Clarissa , Karam Sarah Arangurem
Published: September 2022

Objetivo: O objetivo deste estudo foi descrever e avaliar o conteúdo das publicações realizadas usando a hashtag #clareamentoalaser na rede social Instagram®. Materiais e métodos: Foram avaliadas 622 postagens relacionadas ao procedimento de clareamento dentário com uso de luz/laser, publicadas no primeiro trimestre do ano de 2021 (janeiro a março). As características analisadas foram o tipo de perfil, gênero, opinião exposta no conteúdo da publicação, tipo de conteúdo exposto na publicação, nomenclatura do perfil e número de curtidas. A análise foi realizada através do teste qui-quadrado de Pearson, sendo estipulado um nível de significância considerando p-valor <0,05. Resultados: Dentre as 497 publicações incluídas, 77,26% mostraram-se favoráveis ao uso de luz/laser no clareamento. Os valores apurados na variável número de curtidas variam de 0 a 3.361, com média de 42,56 por publicação. Em relação ao tipo de perfil, 60,16% eram cirurgiões-dentistas e 37,83% empresas ou clínicas odontológicas, sendo o conteúdo da publicação majoritariamente comercial (75,65%). Ainda, 53,12% dos perfis foram identificados como do gênero feminino, 9,05% do gênero masculino e 37,83% outros, como empresas ou clínicas odontológicas. Mais de 70% das publicações feitas por profissionais, perfis leigos e empresas ou clínicas odontológicas foram favoráveis ao uso da luz/laser no clareamento dental (p< 0,0001). Discussão: Este estudo expressa a necessidade de educação em saúde, educação continuada e da prática odontológica baseada em evidências. Conclusão: Na rede social do Instagram®, houve predominância na divulgação de publicações favoráveis quanto a utilização da luz/laser no clareamento dentário, considerando o período do primeiro trimestre de 2021.
Análise macroscópica e radiográfica de dentes decíduos com hiperbilirrubinemia de crianças com doenças hepáticas crônicas e transplante hepático
Authors: Cardozo Rafael Ribeiro , Saguchi André Hayato , De Azevedo Ramiro Anthero , Fujita Reginaldo Raimundo , Macedo Adriana Furtado de
Published: September 2022

Objetivo: identificar mediante análise macroscópica e radiográfica as alterações estruturais em tecidos dentários afetados pela hiperbilirrubinemia, normalmente constatada a partir do sinal clínico de icterícia e provoca o desenvolvimento de pigmentos intrínsecos esverdeados nas estruturas dentárias. Materiais e Métodos: a amostra foi composta por 31 dentes decíduos dividida em grupo controle (n= 7) e grupo experimental (n= 24). As análises macroscópicas foram efetuadas por meio de fotografias individuais padronizadas e as radiográficas obtidas com aquisições de imagem a 9 mA, 70 kVp, distância de 8cm, exposição 0,4 segundos e com XDR Sensor®. As imagens foram convertidas pelo software XDR Brasil 3.1.6 e padronizadas pelo programa GIMP 2.10.22. Os dados da média simples do histograma foram analisados pelo teste T-Student e Mann-Whitney (p<0,05). Resultados: demonstraram a maior intensidade de pigmentação em região cervical da raiz, com diferença de densidade radiográfica estaticamente significante na porção radicular entre os grupos experimental e controle (p=0,043). Na análise da densidade radiográfica da estrutura radicular do grupo experimental houve diferença estaticamente significante (p=0,016) entre os terços cervical e apical. Discussão: Os dados evidenciaram que dentes pigmentados pela hiperbilirrubinemia não possuem alterações na densidade mineral nos terços coronários. Conclusão: Dentes com pigmentação esverdeada bilirrubina possuem diferenças na densidade radiográfica somente na região radicular.
Pandemia de COVID-19 no Brasil: quais as repercussões no comportamento, qualidade do sono, uso de telas e alimentação de crianças?
Authors: De Faria Jaiane Freitas , Sartori Letícia Regina Morello , De Moura Carolina Raposo , Pinto Camila Amaral , Teixeira Rejane Andina , Da Silva Beatriz Costa Bidigaray , Guerreiro Patrícia Osório , Correa Marcos Britto , De Oliveira Luísa Jardim Corrêa
Published: September 2022

Objetivo: Descrever as possíveis repercussões que o distanciamento social e pandemia de COVID-19 promoveram no comportamento, qualidade do sono, uso de telas e alimentação de crianças brasileiras de 0 a 12 anos. Materiais e Métodos: Este estudo observacional descritivo foi realizado através de um questionário online autoaplicado direcionado aos pais, cuidadores ou responsáveis legais de crianças de 0-12 anos. O questionário foi aplicado entre 19 de agosto de 2020 a 19 de setembro de 2020, em dois grupos, um composto por usuários de serviços de saúde e outro pela população em geral. Os dados foram analisados descritivamente, considerando α=5%. Resultados: Compuseram a amostra final 271 respondentes. Segundo os cuidadores, 59,4% das crianças tiveram alterações de comportamento e 48% reportou ou demonstrou medo da COVID-19. Além disso, melhora na qualidade do sono foi reportada de forma importante para crianças de até 2 anos e, 33,3% dos cuidadores em ambos os grupos reportaram piora em qualidade do sono entre 9 e 12 anos. Aumento do uso de telas ocorreu para 85% das crianças. O consumo de alimentos considerados saudáveis se manteve igual para grande parte das crianças e o consumo de alimentos ultraprocessados aumentou para mais de 40% das crianças, principalmente entre 3 e 5 anos e 9 e 12 anos de idade. Discussão: Os resultados encontrados devem ser fonte de atenção a fim de garantir o adequado desenvolvimento infantil após um período de pandemia. Conclusão: O distanciamento social provocado pela pandemia de COVID-19 promoveu repercussões importantes na rotina das crianças avaliadas, impactando negativamente seu comportamento, alimentação e uso de telas. Ainda, a qualidade do sono de crianças maiores foi impactada negativamente, apesar de ter sido observada melhora na qualidade do sono de crianças mais jovens.
The effect of coconut sugar on cariogenic traits in streptococcus mutans
Authors: Rup Ariel Gourlart , Marques Rafaella Christina do Rêgo , Maltz Marisa , Hashizume Lina Naomi , Dame-Teixeira Naile
Published: September 2022

Aim: The consumption of foods rich in sugar is linked to several non-communicable diseases, including dental caries. Coconut sugar has systemic benefits due to its lower glycemic indexes (GI) than other table sugars. However, there is currently no data regarding its cariogenic potential. This study aimed to evaluate the effect of coconut sugar on acidogenicity and adhesion of Streptococcus mutans in vitro, compared to sugarcane products. Materials and methods: Aliquots of cultures of S. mutans UA159 were resuspended in a buffer solution enriched with coconut sugar, crystal sugar (refined sugar), and minimally processed sugarcane (demerara light brown sugar and maskavo dark brown sugar), as well as positive (sucrose) and negative controls. The decrease in pH and its corresponding area under the curve (AUC; cm2) were evaluated for the analysis of acidogenicity. S. mutans was incubated in BHI supplemented with each sugar and the percentages of microbial adhesion were calculated. After testing data normality, the one-way ANOVA test (Bonferroni post hoc) was used to compare the AUC and the proportion of adhesion of each group. Results: Regarding the acidogenic potential, statistical differences were found only between the negative control versus all other groups (p<0.001). Likewise, no significant difference in adhesion was found between the tested sugars (p>0.05). Discussion: Although the tested sugars are marketed as “healthy products,” their amount and frequency of usage should be controlled. Conclusion: Coconut sugar presents a similar cariogenic potential to that of sugarcane products when acidogenicity and adhesion are evaluated. Coconut sugar is not indicated as a substitute for sucrose in the control of cariogenic activity.
Comparação entre métodos cirúrgicos e conservadores para o tratamento de granuloma central de células gigantes descritos na literatura
Authors: Souza Victor Arthur Rodrigues de , Freitas Maria Vitória Aragão , Santos Maryana Cruz , Repeke Carlos Eduardo Palanch
Published: September 2022

Objetivo: Apresentar, através de uma revisão de literatura, métodos de tratamento do Granuloma mais conservadores, estabelecendo comparações entre estes, afim de fornecer à comunidade científica mais clareza e opções mais eficazes e seguras para o paciente. Revisão da literatura: O Granuloma Central de Células Gigantes (GCCG) é uma lesão proliferativa benigna intraóssea de etiologia incerta e comportamento clínico variável que possui como forma de tratamento mais utilizado os métodos cirúrgicos, entretanto, observou-se que os métodos cirúrgicos apresentam alta taxa de recidiva e um grande comprometimento estético e funcional. Em contrapartida, métodos mais conservadores mostram regressão completa da lesão e baixa taxa de recidiva, porém com a desvantagem de apresentar um longo período de tratamento e alguns efeitos adversos. Discussão: Ainda não existe um protocolo de gerenciamento de GCCG, seu manejo clínico deve levar em consideração a possibilidade de combinação de duas ou mais terapias objetivando melhores resultados. Conclusão: Os métodos conservadores são promissores por diminuir o tempo de tratamento e preservar a estética e função, além de ter a possibilidade de serem empregados juntos conforme a necessidade do paciente, apesar de nenhuma forma de tratamento individual ser a ideal.
Produção de tumores em salivares de rato com DMBA
Authors: Ebling Hardy , Louro Leopoldo M. , Brito Jorge H. M. , Wagner Edgar M.
Published: September 2022

Estudam-se os efeitos da implantação do DMBA nas glândulas submandibulares de ratos Wistar depois de 30, 60, 90, 120 e 150 dias. Achou-se que depois de 30 dias o carcinoma epidermóide surgido derivava do epitélio que reveste os cistos epidermóides formados pela implantação do DMBA.
Tumor de Burkitt: histologia dos dentes atingidos pelo tumor
Authors: Ebling Hardy
Published: September 2022

Estudou-se sob o ponto de vista histopatológico material proveniente de um tumor localizado na mandíbula de um menino, de evolução extremamente rápida e fatal, e que era constituído por volumoso fragmento da mandíbula, com incisivos e canino D.
Granuloma à corpo estranho
Authors: Ebling Hardy
Published: September 2022

Apresenta-se casos de granuloma por corpo estranho na mandibula de dois pacientes, provocados por substâncias usadas com finalidade de prevenir hemorragias. Chama-se atenção para o fato de que a formação de granuloma de corpo estranho pode levar o clínico ou o cirurgião a interpretar como recidiva de tumor, indicando ou realizando uma série de cirurgias que podem terminar, como num dos casos apresentados, com a ressecção da mandibula. A solução consiste em não reoperar sem nôvo exame clinico cuidadoso, incluindo radiografias e biópsia, e maior colaboraçáo entre o cirurgião e o patologista.
Fibroma ameloblástico: apresentação de um caso
Authors: Ebling Hardy , Chahér José
Published: September 2022

Apresenta-se caso de fibroma ameloblástico, em moça, de 16 anos, região retro-molar E. Chama-se a atenção para o fato de que possivelmente o prognóstico é muito melhor do que para o ameloblastoma, conforme tem sido publicado na literatura. E pela importância deste fato, é necessário que o patologista seja perfeitamente capaz de diferenciá-los e alertar o cirurgião.
Esquema geral de orientação para o uso apropriado de antibióticos
Authors: Grossman Carlos
Published: September 2022

[Resumo não disponível]
Fraturas do côndilo
Authors: Hoffman Annie F.
Published: September 2022

Revisão bibliográfica das fraturas do côndilo, abrangendo diagnóstico e o tratamento das mesmas.
Hemocitopoiese
Authors: Louro Leopoldo Marques
Published: September 2022

Nenhum resumo disponível
Estudo comparativo entre o material recebido para exame no registro de patologia oral da american dental association e do material da cadeira de patologia da Escola de Odontologia da Universidade do Rio Grande do Sul
Authors: Chahér José , Ebling Hardy , Kac Aron L. , Barbachan João Jorge Diniz
Published: September 2022

Nenhum resumo disponível
Contribuição ao estudo do sangue nos vertebrados
Authors: Brito Jorge Honório Mittelstaedt
Published: September 2022

Nenhum resumo disponível
Estudo das goteiras no tratamento das fraturas mandibulares: modificação da goteira Pichler
Authors: Sant'Ana Manoel
Published: September 2022

Nenhum resumo disponível
Avaliação da ação do colagel® na migração do epitélio juncional em dentes reimplantados: estudo histológico em ratos
Authors: González P. A. H. , Puricelli E. , Busato A. L. S. , Mascarenhas L. C.
Published: September 2022

Trabalho experimental realizado em ratos, utilizando o primeiro molar superior direito como dente teste e o primeiro molar superior esquerdo como dente controle, onde analisa-se a relação entre a migração epitelial e o processo de reabsorção radicular em dentes reimplantados. Verifica-se a capacidade do Colagel® de evitar a migração epitelial.
Toxicologia do flúor
Authors: Ramos Paulo Augusto Verney
Published: September 2022

O autor apresenta o processo toxicolégico em relação ao fluoreto, classificando-o e cita dados que marcam os possiveis limites da intoxicação crônica e aguda, bem como refere os tipos de tratamento e cuidados para cada caso.
A redução das assimetrias regionais em meio à crise da integração sul-americana
Authors: Pini André Mendes , Macedo Guilherme Fenício Alves
Published: September 2022

O artigo examina o papel do Fundo para Convergência Estrutural do Mercosul na redução das assimetrias dos Estados Parte do Mercosul em um contexto de crise da integração regional sul-americana. O foco do artigo são os projetos do FOCEM destinados ao Paraguai. Por meio da metodologia de estudo de caso qualitativo e da ampla utilização de fontes primárias documentais e estatística descritiva, o trabalho argumenta que, embora a integração regional sul-americana, em um sentido amplo, passe por um processo de crise devido à sua característica fragmentada, iniciativas pautadas por elementos técnicos, voltados a concepções sociais da América do Sul demonstraram ser menos suscetíveis às vicissitudes políticas da região, acabando por atenuar os efeitos negativos dessa fragmentação. Os resultados da pesquisa sugerem que o FOCEM, mesmo em um cenário de fragmentação de processos de integração regional e de enfraquecimento do Mercosul, tem sucesso ao desempenhar um papel de redução das assimetrias regionais. Isso ocorre porque além de o FOCEM possuir corpo burocrático consolidado, executa projetos pragmáticos e que geram efeitos sociais coletivos positivos por atuarem em setores como infraestrutura e competitividade regional.
Negotiations in international procurement management
Authors: Moma José
Published: September 2022

This research paper identifies the instrumental role of the integrative perspective in international procurement negotiations and evaluates how, in the specific case of BPN’s purchase by BIC, the long-term relationship approach provided the maximization of opportunities in international relations. The research applied a qualitative method that explored the case of BIC internationalization project within the CPSC (Community of Portuguese Speaking Countries) space and resorted to techniques of documentary observation, collected through interviews, official statements and communications. The study demonstrates that BIC strategy gave rise to subsequent negotiations with the same international partner, under conditions of a more cooperative perspective. Findings validate the relevance of an integrative perspective, but suggest that it is instrumental to competitive purposes and demonstrates that the entry into action of business economic actors is not unrelated to a strong involvement of States, through their governments.
The Internet as an Epistemic Agent (EA)
Authors: Krzanowski Roman , Polak Pawel
Published: September 2022

We argue that the Internet is, and is acting as, an EA because it shapes our belief systems, our worldviews. We explain key concepts for this discussion and provide illustrative examples to support our claims. Furthermore, we explain why recognising the Internet as an EA is important for Internet users and society in general. We discuss several ways in which the Internet influences the choices, beliefs, and attitudes of its users, and we compare this effect with those of psychological conditioning and brainwashing techniques. Finally, we present examples where the Internet’s epistemic agency acts at scale, affecting large portions of society rather than individuals.
Post-cardioversion Atrial Stunning -- Not to be Forgotten
Authors: Naqvi Tasneem , Kurt Merve
Published: September 2022

We present a case of a 60 year old male who found to be in atrial
fibrillation during routine evaluation. Anticoagulation was initiated
for 36 hours and he was referred for TEE guided electrical
cardioversion. There was no thrombus identified in the left atrial
appendage, however the appendage was large and had a tongue like
accessory lobe along with spontanous contrast on the left atrium and its
appendage. TEE probe was not withdrawn, patient underwent successful
cardioversion with 200 joules and developed a thrombus in the left
atrial appendage immediately after cardioversion, which rapidly became
more dense. There was an associated marked decrease in appendage
velocities. Patient was hospitalized to initiate low molecular weight
heparin. This case highlights the need for vigilance in patients with
unknown duration of atrial fibrillation, who have received a short
duration of anticoagulant therapy and who have adverse appendage anatomy
as thrombus may develop immediately after cardioversion despite
anticoagulation.
Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders.
Authors: Saito Ayame , Alvi Sadia , Valant Celine , Carbone Simona , Poole Daniel
Published: September 2022

Gastrointestinal motility is tightly regulated by the enteric nervous
system (ENS). Disruption of coordinated ENS activity can result in
dysmotility. Pharmacological treatment options for dysmotility include
targeting of G protein-coupled receptors (GPCRs) expressed by neurons of
the ENS. Current GPCR-targeting drugs for motility disorders bind to the
highly conserved endogenous ligand binding site and promote
indiscriminate activation or inhibition of the target receptor
throughout the body. This can be associated with significant side-effect
liability and a loss of physiological tone. Allosteric modulators of
GPCRs bind to a distinct site from the endogenous ligand, which is
typically less conserved across multiple receptor subtypes and can
modulate endogenous ligand signalling. Allosteric modulation of GPCRs
that are important for ENS function may provide effective relief from
motility disorders while limiting side-effects. This review will focus
on how allosteric modulators of GPCRs may influence gastrointestinal
motility, using 5-HT, ACh, and opioid receptors as examples.
Forecasting the end time of global COVID-19 infection with the effects of adaptive behaviors and vaccination
Authors: Zhu Guanghu , Zhou Yuhao , Li Zhaowan , Wu Wei , Xiao Jianpeng , Ma Wenjun
Published: September 2022

We developed a deterministic model with multiple compartments by a
system of differential equations, which allows for simulating novel
coronavirus (COVID-19) transmission dynamics with human adaptive
behaviors and vaccine effects, aiming at predicting the end time of
COVID-19 infection in global scale. Based on the surveillance
information (reported cases and vaccination data) between January 22,
2020 and July 18, 2022, we validated the model by MCMC fitting method.
We found that (1) if without protective and control behaviors, the
epidemic could sweep the world in 2022 and 2023, causing 3.098 billion
of human infections, which is 5.39 times of the current number; (2)
there could be 645 million people avoided from infection due to vaccine;
(3) if following current scenarios of protective/control behaviors and
vaccine rate, the cumulative number of cases would increase slowly,
leveling off around 2023, and the epidemic would end completely in June
2025, causing 1.024 billion infections. Our findings suggest that
collective protection behavior and vaccination remain the key
determinants of the global process of COVID-19 transmission.
Resonance-induced acceleration of the RBNE-BNE segregation inversion
Authors: Shao Yufei , Li Anghao , Wang Zaizheng , Huang Decai
Published: September 2022

The experimental and simulation results indicate that the reverse Brazil nut effect (RBNE)-Brazil nut effect (BNE) segregation inversion happens faster in the circular-bottom container than that in the flat-bottom container. The starting location of the sinkage of heavier grains at the top layer is triggered with certain randomness in the latter, whereas it first occurs at either of the lateral bottom edges in the former. The occurrence of standing-wave resonant spots of higher and lower granular temperature accelerates the RBNE-BNE transition. From the elastic collision model of single grain, the bottom with a larger angle leads to more energy transfer from the vertical direction. The simulation results of a monodisperse granular bed confirm that the circular-bottom container possesses a higher granular temperature and a lower packing density at the lateral edges of the circular bottom, whereas the flat-bottom container has a uniform standing-wave distribution with a period.
The Role of Blood Glucose Monitoring in Diabetes Management
Authors: Weinstock Ruth , Aleppo Grazia , Bailey Timothy , Bergenstal Richard , Fisher William , Greenwood Deborah , Young Laura
Published: September 2022

In this monograph, we review issues that are crucial to understand to ensure the optimal and most cost-effective use of BGM. These issues include the accuracy of available glucose meters; the recommended frequency of BGM for PWD who have different types of diabetes and whose diabetes management follows different therapeutic approaches; strategies for using BGM to reach glycemic targets; barriers to BGM use and ways to overcome them; the use of BGM in PWD who also use CGM; and technological innovations such as Cloud-based glucose data management systems, mobile applications (apps), insulin calculators, and remote and automated counseling systems that incorporate BGM to improve care.
Introduction
Authors: Weir Matthew
Published: September 2022

More focus on the earlier identification of patients with type 2 diabetes who are at risk for developing chronic kidney disease (CKD) is needed, especially with regard to biomarkers, genetics, and high-risk phenotypes. Another key area of opportunity is the need for better clinical care models to eliminate socioeconomic and racial disparities. Fortunately, in the past few years, new therapeutic opportunities have been discovered, and more are being considered, for possible use in improving clinical outcomes.
Harmful Algal Blooms Associated Marine Bacteria: Composition and Potential
Authors: M Al Bulushi Ismail
Published: September 2022

The frequency and recurrent of harmful algal blooms (HABs) has increased currently as an impact of the climate change. This phenomenon not only causes sea foods massive killing, but also changes the microbial composition seawater. Harmful algal blooms were found to introduce certain bacterial group and family of sea foods safety important to the sea environment such as Enterobacteriaceae and Vibrio sp. The potential of some introduced bacterial flora such as algicidal has been found. However, the pathogenicity of this flora to the seawater has not been explored. This mini review initially shows the natural composition of marine microflora and analyzes the composition of seawater microbial flora composition associated with HABs with a reference to the algicidal and pathogenicity potential of this flora.
Snake Envenomation: A Component- Based Review on Hemostatic Alterations
Authors: Chudzinski-Tavassi Ana Marisa
Published: September 2022

Considered by the World Health Organization a neglected public health problem, snakebites occur predominantly in tropical areas of Africa, Asia and Latin America. Approximately 2.7 million people worldwide are victims of snakebites each year, of which between 81,000 and 138,000 later die. Among the survivors, about 400,000 have some permanent disability. The entirety of the mechanism responsible for the venom pathophysiology is not completely understood. However, most of the venom toxins affect human hemostasis, as Bothrops venom components, which destabilize endothelium, affect platelet aggregation, blood clotting and fibrinolysis. Such effects are not only components of the clinical picture of patients who have suffered envenomation, but are also directly associated with the severity of the accident. Thus, it is of great importance to understand the main hemostatic alterations observed in envenomation’s by snakes of the genus Bothrops, which is predominant in South America. Therefore, this review describes the hemostatic changes that occur in Bothrops snakebites, to further improve the understanding of the general pathological mechanisms of snake envenomation’s and the correlation between endothelium dysfunction and coagulation/fibrinolysis systems as a result of the interaction of each class of venom components with human hemostasis. This knowledge is crucial for the development of new effective therapeutic approaches, attenuating the severity of snakebites and reducing amputations and deaths. Besides this, a molecular comprehension of the hemostatic alterations caused by each component of Bothrops venoms may help to identify new molecules and targets for therapeutic applications.
Effect of 17α-Ethinylestradiol on the Intestinal Calcium Carbonate Excretion Rate of Yellow Fin Sea Bream (Acanthopagrus latus)
Authors: Al Jandal N
Published: September 2022

Marine fish maintain their hypotonic body fluids by drinking seawater, excreting excess salt, and retaining water. Calcium in seawater is precipitated as CaCO3 in marine fish gut to limit the Ca2+ availability for absorption from the ingested water to maintain Ca2+ homeostasis; this process is controlled by endocrine functions. This study was aimed to investigate the effect of the exposure to synthetic estrogen; ethinylestradiol (EE2), on the osmoregulation process (CaCO3 excretion rate from the intestine) and reproduction in the native fish species of Kuwait. The fish were exposed in a semi-static system to three treatments (control and 5 and 10 ng EE2/l of seawater) for two weeks, and then the terminal sampling was carried out. Blood samples were taken for vitellogenin (Vtg) analysis using Western blotting, dot blot, and immunohistochemistry (IHC). Calcium carbonate samples were analysed for the excretion rate and showed no significant difference in treatments indicating that no effect on osmoregulation was observed. Water samples were analyzed by the enzyme-linked immunosorbent assay (ELISA) for the concentration of EE2 in the exposure tanks, showing a 50% decrease in the nominal concentration after 24 h of exposure. Fish gonads and liver were dissected for histological examination, showing no obvious intersex in control and lowdose exposed group, whereas the high-dose exposed group showed signs of intersex. No Vtg was induced in the plasma and that could be due to many factors such as low concentrations received in the exposure tanks (2.3 and 4.9 ng/l), fish species, and exposure period. The hepatosomatic index showed no significant difference between treatments and the gonadosomatic index showed a significant difference between the control and high-dose group. Interesting results were obtained from IHC, where Vtg was localized in both treatments, although more Vtg was detected in higher-dose exposed fish for both tissues (liver and gonads).
The Role of Nerve Growth Factor in Alergic Reactions and Healing Process of Tissues
Authors: Ferjan Ilonka
Published: September 2022

Nerve growth factor is a protein which regulates the differentiation and survival of nerve system. It is produced in neurons and in several non-nervous cells which are involved in some inflammatory and immunological states. These cells include mast cells, lymphocytes, macrophages and fibroblasts. Mast cells play a crucial role in the inflammatory and allergic reactions. Inflammatory cells express specific receptors for binding NGF, tyrosine kinase (TrkA) receptor. Binding of nerve growth factor to this receptor activates the immune cells. Activation of the cells leads to secretion of many inflammatory mediators from them. The mediators (histamine, serotonin, tryptase and some interlevkines) are involved in the early response of inflammatory cells. The cytokines and growth factors produced later in the inflammatory process activate fibroblasts and other cells, which participate in healing process of tissues.
The Role of Mitochondria in Ozone Therapy
Authors: Peixoto Francisco
Published: September 2022

Inhaled ozone can react with the biomolecules present in the epithelial lining fluid, causing the depletion of antioxidants. It can react with the surfactant polyunsaturated fatty acids (PUFA) present at the air-ELF interface to form several reactive oxygen species (ROS). High ozone exposure resulted in sustained ventricular tachycardia in male and female rats. Ozone can induce oxidative stress, alter some inflammatory factors in tissue, and induce mitochondria-dependent apoptosis. It is not surprising that the mitochondria could be putatively affected by ozone as this organelle is highly sensitive to oxidative stress. Exposure of blood to a few micrograms of ozone was shown to cause a decrease in mitochondrial function and energy metabolism, as it caused a decline in ATP levels and an increase in the NADH/NAD+ ratio. It was also found that cytochrome-c-oxidase was almost wholly inhibited under these conditions. However, in a specific range of concentrations, ozone can induce a beneficial modulation in the anti-inflammatory and antioxidant systems. Some of the biological responses induced by ozone may be potentially suitable to become an active part of the various mechanisms of metabolic regulation, with positive effects on several pathologies. The therapeutic efficacy of ozone therapy may result from controlled and moderate oxidative stress produced by ozone’s reactions with various biological components. Although there is not enough data, there are indications that ozone may induce good responses in mitochondria.