bluuebunny/crossref_metadata_2025 huggingface dataset:
New Thinking in Austrian Economics
Authors: Boettke Peter J. , Coyne Christopher J.
Published: April 2023

This review discusses the unique features of Austrian economics and some of the recent contributions of this school of thought. We organize these contributions in different research “buckets” in the hope that this will be a useful guide to readers while demonstrating the ongoing relevance of the contemporary Austrian school of economics for advancing scientific discourse. The research buckets discussed include robust political economy, macroeconomics, monetary economics, entrepreneurship and the market process, development economics, behavioral economics, governance, social economy, collective action challenges related to natural disaster recovery and infectious disease, and war and defense.
Not Dead Yet
Authors: Diamond Betty
Published: April 2023

I have been a scientific grasshopper throughout my career, moving from question to question within the domain of lupus. This has proven to be immensely gratifying. Scientific exploration is endlessly fascinating, and succeeding in studies you care about with colleagues and trainees leads to strong and lasting bonds. Science isn't easy; being a woman in science presents challenges, but the drive to understand a disease remains strong.
eMeD: An Experimental Study of an Autonomous Wearable System with Hybrid Energy Harvester for Internet of Medical Things
Authors: Chong Yung-Wey , Ismail Widad , Yau Kok-Lim Alvin
Published: April 2023

We propose and experimentally validate a hybrid energy harvester embedded in a wearable system used to measure real‐time information, such as body temperature, heartbeat, blood oxygen saturation (SpO2), and movement (or acceleration) of human body in real time. This hybrid energy harvester, or in short eMeD, has a unique design that can improve the energy efficiency of the overall wearable system and extract more energy from ambient sources. Specifically, the wearable system is integrated with a hybrid photovoltaic‐radio frequency (RF) energy harvester as the power source to prolong its lifetime and reduce the dependence on battery energy. Experimentally, the current consumption of the wearable system with load switching and event management algorithm improved from 31 mA to 18.6 mA. In addition, the maximum conversion efficiency is 14.35%. The experimental results illustrate a sustainable and long‐term monitoring operation for Internet of Medical Things systems.
Intelligent System for Optimal Geometric Design Using Fuzzy Soft PDE
Authors: Jamil Nosshad , Kirmani Syed , Wadeer Shakrullah , Sultanl Alqa
Published: April 2023

In this research, a methodology is discussed to develop an intelligent system for optimal geometric design for the culinary product. An optimum geometric design meets certain specified criteria in the most efficient or cost‐effective way possible. The criterion for an optimum design will depend on the specific goals and constraints of the specific problem. In this methodology, partial differential equation and weighted Bonferroni mean are consolidated to develop the intelligent system for optimal geometric designs for the required product with the blend of fuzzy soft sets. Fuzzy soft sets allow capturing the incorporation of subjective or personal opinions into decision‐making processes, as well as the consideration of multiple conflicting criteria. A parameter known as the smoothness parameter is used to control the shape of the optimal geometric model. The smoothness parameter, used as a fuzzy number, is important in this developed system as it fulfills the requirements for the desired intelligent system for product design according to the industries’ demands. To verify the credibility of this system, an illustrated example is presented to design a culinary product, which is profitable for the hotel industry.
Numerical Approximation of One‐Dimensional Transport Model Using an Hybrid Approach in Finite Volume Method
Authors: Hussain Arafat , Ali Rashid
Published: April 2023

A finite volume method is a well‐known and appropriate approach for numerical approximation of governing problems. This article proposes a finite volume approach to simulate the one‐dimensional convection–diffusion transport problem. New expressions for interface approximation are constructed by combining the assumption of step‐wise profile and piece‐wise linear profile. In addition, a new numerical technique is developed based on these new interface approximations. This new numerical algorithm produces consistent results for numerical approximation of the governing problem and gives second‐order accuracy along space and time. In order to justify the effectiveness of our numerical technique, numerical experiments are conducted for various magnitudes of convection and diffusion coefficients. The numerical results of the proposed algorithm are also compared to the finite volume method and the finite difference method. Based on this comparison, our numerical scheme presents stable and highly accurate results compared to the alternatives.
Evaluation and Application of Public Management Service Quality of Smart City Based on Intelligent Computing
Authors: Lu Yang
Published: April 2023

The service quality of smart city public management is the direction of modern city management construction of Chinese local government, but the current work of smart city management construction and management is not perfect. Among them, the most obvious and prominent problem is that there is no evaluation system for the public management service quality of smart cities, which makes it difficult to achieve the expected effect in the actual construction process without considering all factors. In this case, it is necessary to establish a complete and effective smart city management evaluation system to ensure the rationality and effectiveness of urban management input, which is a problem that must be solved by the current smart city local government smart city public management service quality. In this context, this paper first introduces and analyzes the research background, purpose, and significance of public satisfaction with public information services in smart cities. The origin, significance, and application status of smart cities are sorted out, the relationship between them is elaborated, and the overall research framework is determined. Second, the evaluation model of public management service quality of a smart city based on the fuzzy analytic hierarchy process is constructed, and the theoretical basis of this satisfaction model is elaborated. Finally, the simulation results demonstrate the effectiveness and practicability of the proposed method.
Prediction of Chemical Corrosion Rate and Remaining Life of Buried Oil and Gas Pipelines in Changqing Gas Field
Authors: Li Xianbing , Liu Rui , Ma Dong , Bai Yang , Shi Yukai , Anhouck Badm
Published: April 2023

Green synthesis and metal oxide composites have attracted much attention from researchers of industry and academia. As a typical application of green synthesis and metal oxide composites, the continuous change of industrial technology and the continuous improvement of the social and economic level, the demand for oil and gas are also increasing. However, the spatial gap between the place of origin and the place of demand for oil and gas resources is large, so the long-distance oil and gas pipeline came into being. However, under the action of time, coupled with the corrosion effect of the soil due to deep burial, some pipelines have serious aging and corrosion phenomena. Therefore, in order to give corresponding guarantees for economic development, we need to conduct in-depth research and analysis of the corrosion of oil and gas long-distance pipelines and give effective solutions. In this paper, the corrosion rate prediction of buried oil and gas pipelines is studied in Changqing gas field. By improving the inertial weights and learning factors of the traditional particle swarm algorithm, the parameters of the generalized regression neural network are optimized and selected, and the corrosion rate prediction model of buried pipelines is finally constructed. Comparative analysis with other swarm intelligence algorithms shows that the improved particle swarm algorithm has stronger convergence ability and higher prediction accuracy than the BP model and SVM model. In addition, based on the detection data collected at the site of the gathering and transportation pipeline in Changqing gas field, this paper uses the extreme value distribution theory and the local corrosion progress formula to establish a prediction model for the residual life of corrosion of buried pipelines. The model established in this paper can effectively determine the risk pipe segment of buried pipeline and provide a decision-making basis for pipeline management departments. The work provides an important application guidance to green synthesis and metal oxide composites.
[Retracted] Motion Control and Tracking Control of UAV Based on Adaptive Sensor
Authors: Zhao Xin , Xu Zhihui , Fu Yifeng , Xu Shoupeng , Xiong Shasha
Published: April 2023

In order to meet the requirements of UAV motion control and tracking control, an adaptive sensor‐based technology is proposed. The main content of the technology is based on the mathematical model of the adaptive sensor, through the quaternion attitude update model, using nonlinear attitude SVDCK filtering and dynamic adaptive adjustment factors and other technologies, and finally through simulation experiments and analysis to build the research means of UAV motion control and tracking control system. The experimental results show that the roll Angle, pitch Angle, and yaw Angle of SVDCKF are 1.703, 1.972, and 1.928, respectively. By adjusting the dynamic adaptive factor, the attitude‐filtering algorithm reduces the error of the attitude solution and improves the robustness of the attitude solution under high dynamic conditions. Conclusion. The technology research based on adaptive sensor can meet the requirements of UAV motion control and tracking control.
Impact of Commercial Sugar as a Substrate in Single-Chamber Microbial Fuel Cells to Improve the Energy Production with Bioremediation of Metals
Authors: Omenesa Idris Mustapha , Al-Zaqri Nabil , Warad Ismail , Hossain Al-Mustasin Abir , Masud Nahian , Ali Mohammed
Published: April 2023

Microbial fuel cells (MFCs) have emerged as a viable method for bioremediation of toxic metals while also producing energy. In this paper, we examine the issue of organic substrate as a source of metabolism for microbe growth in MFC, as well as its significance for metal ion degradation in tandem with energy production. This study focused on the use of commercial sugar as an organic substrate in a single-chamber MFC. The MFC was operated for 27 days, with the highest voltage of 150 mV achieved on day 12, and toxic metal bioremediation efficiencies of 89%, 76.45%, and 89.45% for Pb2+, Cd2+, and Hg2+, respectively. Every 24 hours, the organic substrate (sugar solution) was fed into the cell. This study’s mechanism of metal ion degradation and electron transport is also thoroughly described. In addition, some future views have been highlighted.
Table S4 from Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial
Authors: Hong David S. , Postow Michael , Chmielowski Bartosz , Sullivan Ryan , Patnaik Amita , Cohen Ezra E.W. , Shapiro Geoffrey , Steuer Conor , Gutierrez Martin , Yeckes-Rodin Heather , Ilaria Robert , O'Connell Brenda , Peng Joanna , Peng Guangbin , Zizlsperger Nora , Tolcher Anthony , Wolchok Jedd D.
Published: April 2023

Representativeness of Study Participants
Table S1 from Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial
Authors: Hong David S. , Postow Michael , Chmielowski Bartosz , Sullivan Ryan , Patnaik Amita , Cohen Ezra E.W. , Shapiro Geoffrey , Steuer Conor , Gutierrez Martin , Yeckes-Rodin Heather , Ilaria Robert , O'Connell Brenda , Peng Joanna , Peng Guangbin , Zizlsperger Nora , Tolcher Anthony , Wolchok Jedd D.
Published: April 2023

Geometric mean (geometric CV%) of eganelisib PK parameters in patients with solid tumors in the monotherapy cohort
Data from Antitumor Efficacy of Dual Blockade with Encorafenib + Cetuximab in Combination with Chemotherapy in Human BRAFV600E-Mutant Colorectal Cancer
Authors: Napolitano Stefania , Woods Melanie , Lee Hey Min , De Falco Vincenzo , Martini Giulia , Della Corte Carminia Maria , Martinelli Erika , Famiglietti Vincenzo , Ciardiello Davide , Anderson Amanda , Fowlkes Natalie Wall , Villareal Oscar Eduardo , Sorokin Alexey , Kanikarla Preeti , Coker Olu , Morris Van , Altucci Lucia , Tabernero Josep , Troiani Teresa , Ciardiello Fortunato , Kopetz Scott
Published: April 2023

AbstractPurpose:
Encorafenib + cetuximab (E+C) is an effective therapeutic option in chemorefractory BRAFV600E metastatic colorectal cancer (mCRC). However, there is a need to improve the efficacy of this molecular-targeted therapy and evaluate regimens suitable for untreated BRAFV600E in patients with mCRC.
Experimental Design:
We performed a series of in vivo studies using BRAFV600E mCRC tumor xenografts. Mice were randomized to receive 5-fluoruracil (5-FU), irinotecan, or oxaliplatin regimens (FOLFIRI or FOLFOX), (E+C) or the combination. Patients received long-term treatment until disease progression, with deescalation strategies used to mimic maintenance therapy. Transcriptomic changes after progression on cytotoxic chemotherapy or targeted therapy were assessed.
Results:
Antitumor activity of either FOLFIRI or E+C was better as first-line treatment as compared with second-line, with partial cross-resistance seen between a cytotoxic regimen and targeted therapy with an average 62% loss of efficacy for FOLFIRI after E+C and a 45% loss of efficacy of E+C after FOLFIRI (P < 0.001 for both). FOLFIRI-treated models had upregulation of epithelial–mesenchymal transition (EMT) and MAPK pathway activation, where E+C treated models had suppressed MAPK signaling. In contrast, with chemotherapy with E+C, EMT and MAPK signaling remained suppressed. FOLFOX or FOLFIRI, each in combination with E+C, were the most active first-line treatments as compared with E+C or to chemotherapy alone. Furthermore, FOLFOX in combination with E+C as first-line induction therapy, followed by E+C ± 5-FU as maintenance therapy, was the most effective strategy for long-term disease control.
Conclusions:
These results support the combination of cytotoxic chemotherapy and molecular-targeted therapy as a promising therapeutic approach in the first-line treatment of BRAFV600E mCRC.
Data from Frequent Overexpression of HER3 in Brain Metastases from Breast and Lung Cancer
Authors: Tomasich Erwin , Steindl Ariane , Paiato Christina , Hatziioannou Teresa , Kleinberger Markus , Berchtold Luzia , Puhr Rainer , Hainfellner Johannes A. , Müllauer Leonhard , Widhalm Georg , Eckert Franziska , Bartsch Rupert , Heller Gerwin , Preusser Matthias , Berghoff Anna Sophie
Published: April 2023

AbstractPurpose:
HER3 belongs to a family of receptor tyrosine kinases with oncogenic properties and is targeted by a variety of novel anticancer agents. There is a huge unmet medical need for systemic treatment options in patients with brain metastases (BM). Therefore, we aimed to investigate HER3 expression in BM of breast (BCa) and non–small cell lung cancer (NSCLC) as the basis for future clinical trial design.
Experimental Design:
We analyzed 180 BM samples of breast cancer or NSCLC and 47 corresponding NSCLC extracranial tissue. IHC was performed to evaluate protein expression of HER3, and immune cells based on CD3, CD8, and CD68. To identify dysregulated pathways based on differential DNA methylation patterns, we used Infinium MethylationEPIC microarrays.
Results:
A total of 99/132 (75.0%) of BCa-BM and 35/48 (72.9%) of NSCLC-BM presented with HER3 expression. Among breast cancer, HER2-positive and HER2-low BM showed significantly higher rates of HER3 coexpression than HER2-negative BM (87.1%/85.7% vs. 61.0%, P = 0.004). Among NSCLC, HER3 was more abundantly expressed in BM than in matched extracranial samples (72.9% vs. 41.3%, P = 0.003). No correlation of HER3 expression and intratumoral immune cell density was observed. HER3 expression did not correlate with overall survival from BM diagnosis. Methylation signatures differed according to HER3 status in BCa-BM samples. Pathway analysis revealed subtype-specific differences, such as TrkB and Wnt signaling pathways dysregulated in HER2-positive and triple-negative breast cancer BM, respectively.
Conclusions:
HER3 is highly abundant in BM of breast cancer and NSCLC. Given the promising results of antibody–drug conjugates in extracranial disease, BM-specific trials that target HER3 are warranted.
Supplementary Figure 3 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma
Authors: Dunbar Karen J. , Karakasheva Tatiana A. , Tang Qiaosi , Efe Gizem , Lin Eric W. , Harris Michael , Sahu Varun , Sachdeva Uma M. , Hu Jianhua , Klein-Szanto Andres J. , Henick Brian , Diehl J. Alan , Nakagawa Hiroshi , Rustgi Anil K.
Published: April 2023

ERK1/2 signaling pathway in CCL5 knockout cells.
Phase II Trial of Nelipepimut-S Peptide Vaccine in Women with Ductal Carcinoma In Situ
Authors: O'Shea Anne E. , Clifton Guy T. , Qiao Na , Heckman-Stoddard Brandy M. , Wojtowicz Malgorzata , Dimond Eileen , Bedrosian Isabelle , Weber Diane , Garber Judy E. , Husband Alexander , Pastorello Ricardo , Lee J. Jack , Hernandez Mike , Liu Diane D. , Vornik Lana A. , Brown Powel H. , Alatrash Gheath , Peoples George E. , Mittendorf Elizabeth A.
Published: April 2023

NeuVax is a vaccine comprised of the HER2-derived MHC class I peptide E75 (nelipepimut-S, NPS) combined with GM-CSF. We completed a randomized trial of preoperative vaccination with NeuVax versus GM-CSF alone in patients with ductal carcinoma in situ (DCIS). The primary objective was to evaluate for NPS-specific cytotoxic T lymphocyte (CTL) responses. Patients with human leukocyte antigen (HLA)-A2-positive DCIS were enrolled and randomized 2:1 to NeuVax versus GM-CSF alone and received two inoculations prior to surgery. The number of NPS-specific CTL was measured pre-vaccination, at surgery, and 1 and 3 to 6 months post-operation by dextramer assay. Differences in CTL responses between groups and between pre-vaccination and 1-month post-operation were analyzed using a two-sample t test or Wilcoxon rank sum test. The incidence and severity of adverse events were compared between groups. Overall, 45 patients were registered; 20 patients were HLA-A2 negative, 7 declined participation, 1 withdrew, and 4 failed screening for other reasons. The remaining 13 were randomized to NeuVax (n = 9) or GM-CSF alone (n = 4). Vaccination was well-tolerated with similar treatment-related toxicity between groups with the majority (>89%) of adverse events being grade 1. The percentage of NPS-specific CTLs increased in both arms between baseline (pre-vaccination) and 1-month post-operation. The increase was numerically greater in the NPS+GM-CSF arm, but the difference was not statistically significant. NPS+GM-CSF is safe and well-tolerated when given preoperatively to patients with DCIS. In patients with HLA-A2-positive DCIS, two inoculations with NPS+GM-CSF can induce in vivo immunity and a continued antigen-specific T-cell response 1-month postsurgery.

Prevention Relevance:

This trial showed that vaccination of patients with HLA-A2-positive DCIS with NeuVax in the preoperative setting can induce a sustained antigen-specific T-cell response. This provides proof of principle that vaccination in the preoperative or adjuvant setting may stimulate an adaptive immune response that could potentially prevent disease recurrence.
Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer
Authors: Wan Ledong , Lin Kuan-Ting , Rahman Mohammad Alinoor , Ishigami Yuma , Wang Zhikai , Jensen Mads A. , Wilkinson John E. , Park Youngkyu , Tuveson David A. , Krainer Adrian R.
Published: April 2023

Inflammation is strongly associated with pancreatic ductal adenocarcinoma (PDAC), a highly lethal malignancy. Dysregulated RNA splicing factors have been widely reported in tumorigenesis, but their involvement in pancreatitis and PDAC is not well understood. Here, we report that the splicing factor SRSF1 is highly expressed in pancreatitis, PDAC precursor lesions, and tumors. Increased SRSF1 is sufficient to induce pancreatitis and accelerate KRASG12D-mediated PDAC. Mechanistically, SRSF1 activates MAPK signaling—partly by upregulating interleukin 1 receptor type 1 (IL1R1) through alternative-splicing-regulated mRNA stability. Additionally, SRSF1 protein is destabilized through a negative feedback mechanism in phenotypically normal epithelial cells expressing KRASG12D in mouse pancreas and in pancreas organoids acutely expressing KRASG12D, buffering MAPK signaling and maintaining pancreas cell homeostasis. This negative feedback regulation of SRSF1 is overcome by hyperactive MYC, facilitating PDAC tumorigenesis. Our findings implicate SRSF1 in the etiology of pancreatitis and PDAC, and point to SRSF1-misregulated alternative splicing as a potential therapeutic target.

Significance:

We describe the regulation of splicing factor SRSF1 expression in the context of pancreas cell identity, plasticity, and inflammation. SRSF1 protein downregulation is involved in a negative feedback cellular response to KRASG12D expression, contributing to pancreas cell homeostasis. Conversely, upregulated SRSF1 promotes pancreatitis and accelerates KRASG12D-mediated tumorigenesis through enhanced IL1 and MAPK signaling.

This article is highlighted in the In This Issue feature, p. 1501
Supplementary Figure S2 from Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration
Authors: Nóbrega-Pereira Sandrina , Santos Francisco , Oliveira Santos Miguel , Serafim Teresa L. , Lopes Ana Patrícia , Coutinho Diogo , Carvalho Filipa S. , Domingues Rosário M. , Domingues Pedro , Bernardes de Jesus Bruno , Morais Vanessa A. , Dias Sérgio
Published: April 2023

LDL exposure induces mitochondrial network spread distribution and destabilized cristae in migrating breast cancer cells. Related to Fig. 2
Supplementary Table 3 from Dissecting the origin of heterogeneity in uterine and ovarian carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: April 2023

List of differentially methylated gene promoters (paired analysis of 5 selected tumors).
Figure S16 from Dissecting the origin of heterogeneity in uterine and ovarian carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: April 2023

Complete clonal evolution of P15 tumor.
Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: April 2023

Gynecologic carcinosarcomas (CS) are biphasic neoplasms composed of carcinomatous (C) and sarcomatous (S) malignant components. Because of their rarity and histologic complexity, genetic and functional studies on CS are scarce and the mechanisms of initiation and development remain largely unknown.

Whole-genome analysis of the C and S components reveals shared genomic alterations, thus emphasizing the clonal evolution of CS. Reconstructions of the evolutionary history of each tumor further reveal that C and S samples are composed of both ancestral cell populations and component-specific subclones, supporting a common origin followed by distinct evolutionary trajectories. However, while we do not find any recurrent genomic features associated with phenotypic divergence, transcriptomic and methylome analyses identify a common mechanism across the cohort, the epithelial-to-mesenchymal transition (EMT), suggesting a role for nongenetic factors in inflicting changes to cellular fate. Altogether, these data accredit the hypothesis that CS tumors are driven by both clonal evolution and transcriptomic reprogramming, essential for susceptibility to transdifferentiation upon encountering environmental cues, thus linking CS heterogeneity to genetic, transcriptomic, and epigenetic influences.

Significance:

We have provided a detailed characterization of the genomic landscape of CS and identified EMT as a common mechanism associated with phenotypic divergence, linking CS heterogeneity to genetic, transcriptomic, and epigenetic influences.
Recent Foraminifera from the coast of Mumbai, India: distribution and ecology
Authors: Ganapati Ramesh Naik  , Manisha Nitin Kulkarni  , Indap Madhavi Manohar
Published: April 2023

Foraminifera have been used in biostratigraphy and paleoenvironmental research. They are useful environmental indicators for monitoring the marine environment. Intertidal sediment samples were analysed for their diversity in relation to physicochemical parameters and sediment characteristics along the Mumbai coast of India. Thirty-five species were found, divided into five orders and 18 families. The orders Rotaliida and Miliolida were identified to be dominant. Foraminifera were observed to be inversely related to sand particle size in relation to sediment and physicochemical parameters of water. Canonical correlation analysis explained the relationship between species abundance and water physicochemical parameters.
Diversity of bracket fungi (Basidiomycota: Agaricomycetes: Polyporaceae) in Jammu Division, Jammu & Kashmir, India
Authors: Bala Brij
Published: April 2023

The 24 taxa comprising of 13 genera belonging to Polyporaceae (Basidiomycota, Agaricomycetes) are described and illustrated on the basis of basidiome collected during the rainy season in the years from 2014–2019 in Doda, Jammu, Kathua, Kishtwar, Ramban, and Udhampur districts of Jammu division of the Union Territory of Jammu & Kashmir. Of these, five (Dichomitus campestris, Perenniporia adnata, Pilatoporus bondartsevae, Polyporus efibulatus, and Tyromyces amazonicus) are new records for India, 14 (Abortiporus biennis, Cerrena zonata, Favolus glaber, Fuscopostia leucomallella, Hexagonia nitida, Lenzites elegans, Lenzites warnieri, Perreniporia  fraxniea, P. ochroleuca, Poriella subacida, Polyporus alveolaris, Pycnoporus sanguineus, Tyromyces chioneus, and Trichaptum biforme), are new records for the Union territory of Jammu & Kashmir, two (Pycnoporus cinnabarinus and Polyporus squamosus), and the remaining three (Fomes fomentarius, Lenzites betulina, and Trichaptum abietinum) are re-recorded from the study area.
A study on the breeding habits of Red-wattled Lapwing Vanellus indicus Boddaert, 1783 (Aves: Charadriformes: Charadridae) in the agricultural landscape of Muzaffarnagar District, Uttar Pradesh, India
Authors: Arya Ashish Kumar , Joshi Kamal Kant , Kumar Deepak , Bachheti Archana
Published: April 2023

This study investigated the breeding biology of Red-wattled Lapwing Vanellus indicus in the agricultural landscape of district Muzaffarnagar, Uttar Pradesh, India, during three consecutive breeding sessions (2019–2021). A maximum of 25 nests and average clutch sizes of 3.64 ± 0.49 were recorded in 2021. Hatching success estimated using the Mayfield method was 55% in 2019, 64% in 2020, and 65% in 2021; values  obtained using the traditional method were 42%, 58%, and 53%, respectively. During 2019 and 2021, 3.8% and 3.3% (respectively) of eggs did not successfully develop, while no hatching failures were recorded in 2020. In total, 32% of eggs were destroyed during the study period by predators (cats, dogs, and foxes), and an average of 15% of eggs were destroyed due to anthropogenic activities such as agricultural practices. Red-wattled Lapwings displayed cryptic behavior and active defense against predators making them a successful open nesting species.
Earthworm (Annelida: Clitellata) fauna of Chhattisgarh, India
Authors: M. Nurul Hasan  , Ahmed Shakoor , Deuti Kaushik , Marimuthu Nithyanandam
Published: April 2023

Present communication is the first study on earthworm fauna of Chhattisgarh in central India. A total of nine species belonging to seven genera and five families—Moniligastridae, Eudrilidae, Lumbricidae, Megascolecidae, and Octochaetidae—were collected from different parts of the state. Among the families, Megascolecidae is most dominant with maximum number of species; other families are represented by a single species in each. The earthworm fauna of the  state is comprised of both native (5 species) and exotic peregrine (4 species). A brief description, distribution and identification key for the recorded species is provided. Further surveys are required, which could lead to finding of more species.
Additional breeding records of Hanuman Plover Charadrius seebohmi E. Hartert & A.C. Jackson, 1915 (Aves: Charadriiformes: Charadriidae) from southeastern coast of India
Authors: Byju H. , Raveendran N. , Ravichandran S. , Kishore R.
Published: April 2023

The recent re-evaluation of the systematic status of the Kentish Plover subspecies Charadrius alexandrinus seebohmi to a new taxon, Hanuman Plover Charadrius seebohmi, highlighted the gaps in the research on shorebirds in the Central Asian Flyway. We are presenting four new breeding records of Hanuman Plover; three from the Gulf of Mannar and one from Point Calimere. These sites are the nearest south-eastern Indian sites to the Mannar region of Sri Lanka. Hence the need for Hanuman Plover’s description as a regional endemic with conservation prioritization, making it a flagship species in CAF in Sri Lanka and southern India.
Rediscovery and redescription of Urolabida nilgirica Yang (Hemiptera: Heteroptera: Urostylididae) from India
Authors: Pratik Pansare  , H. Sankararaman  , Hemant V. Ghate
Published: April 2023

Urolabida nilgirica Yang, 1938 is rediscovered and redescribed from India after 85 years since its original description. A brief redescription of this species along with the images of live habitus, various diagnostic characters, and genitalia are provided.
Review Essay on Jacques Berlinerblau, Secularism: The Basics
Authors: Verma Vidhu
Published: April 2023

Jacques Berlinerblau’s “Secularism: The Basics” asks how much and what kind of state separation from religion is required to secure the multiple notions of secularism that have come to dominate debates on faith in the global context. By organizing the book around a distinct set of issues, including questions about the meanings of secularism and its appearance in different contexts that benefit liberal democracy, Berlinerblau implicitly gives voice to the continuity of the tradition of secularism for a large segment of the academic field that has been evolving for the last three decades. While opposing secularism as a monocultural phenomenon, he grapples with the normative pre-definition of political secularism that refers to legally binding actions of the secular state that seek to regulate the relationship between itself and religious citizens and between religious citizens.
Approval and Dissent, on Secularism: The Basics
Authors: Bangstad Sindre
Published: April 2023

My article offers commentary about Jacques Berlinerblau's new book Secularism: The Basics.
Commentary on Secularism: The Basics
Authors: Gutkowski Stacey
Published: April 2023

My article offers commentary about Jacques Berlinerblau's new book Secularism: The Basics.
Gradient Release Drug Composite Nanofibrous Membrane Designed for Preventing Tumor Recurrence and Repair of Postoperative Bladder Cancer Defect
Authors: Huang Yiqiao , Mao Yun-Yi , Zeng Guohao , You Huimin , Lai Dehui , Bian Jun , Chen Jiahui , Zhao Shuo , Ren Congling , Pan Xiaolin , Liang Xue , Dong Weimin , Zhang Zhiming , Jin Lin , Jiang Xianhan
Published: April 2023

Bladder tumor is the most common tumor in urology. Tumor resection as a conventional therapy is usually used in the clinical treatment. However, the electric incision wound produced during the operation is generally deep into the muscle layer. In addition, the multiple tumors and the
large wound sites will bring complications. These outcomes increase the pain and the economic burden of patients. Herein, a composite nanofibers-drug release system (CNFs-DRS) was designed based on the various degradable nanofibers. The experimental results show that the prepared CNFs-DRS
exhibits good biocompatibility, and the anti-tumor drugs (pirarubicin) carried by the first layer are released rapidly within 2–4 h with the ability to kill tumor cells. The second layer consists of slow-degrading material and basic fibroblast growth factor (bFGF), which shows a long-term
and stable release, and promotes the proliferation of smooth muscle cells and the proliferation of urine-derived stem cells (USCs). The third layer (PLLA layer) can maintain the morphology of the composite membrane. The obtained CNFs-DRS can replace and simplify the clinical operation of bladder
chemical drug perfusion within 24 h after operation, immediately kill the residual tumor cells in the bladder, and support and repair the wound after tumor resection.
Zinc Finger Protein 479 Promotes Metastasis and Epithelial-Mesenchymal Transition in Gastric Cancer via MEK/ERK/DNMT1 Signaling Pathway
Authors: Jin Xiaosheng , Ji Tingting , Shi Zhengchao , Zhang Qingqing , Ye Fangpeng , Yu Weilai , Li Rongzhou
Published: April 2023

The carcinogenic function of zinc finger protein 479 (ZNF479) has been found in a few sorts of cancer. However, the part of ZNF479 in gastric cancer remains vague. In this study, the effect of ZNF479 on gastric cancer cell survival, metastasis and epithelial mesenchymal transition (EMT)
was investigated using the Cell Counting Kit-8 (CCK-8), flow cytometry, and transwell assays. Immunofluorescence assay and Western blot was carried out to evaluate the levels of cell cycle, EMT, and MEK/ERK/DNMT1 pathway-related proteins. A lung metastasis cancer mice model was constructed
to evaluate the function of ZNF479 on tumor metastasis in vivo. We noticed that overexpression of ZNF479 promoted cell growth, cell cycle progression, invasion and EMT of gastric cancer cells, whereas ZNF479 knockdown appeared the inverse comes about. Moreover, downregulation of ZNF479
hindered tumor metastasis in mice. Advanced investigation implied that ZNF479 was engaged in the regulation of gastric cancer progression by affecting the MEK/ERK/DNMT1 pathway for that the MEK-specific inhibitor PD98059 reversed the impact of ZNF479 overexpression on gastric cancer cells
and repressed MEK/ERK/DNMT1 signal. In conclusion, ZNF479 promotes gastric cancer cells by activating the MEK/ERK/DNMT1 pathway, ZNF479 may give a new and viable gene target for gastric cancer intercession.
The Role of Virtual Communication in Building an Intertwined Relation Between Business Resilience and Community Resilience during the COVID-19 Pandemic
Authors: Bernal-Turnes Paloma , Ernst Ricardo , Ordeix Enric
Published: April 2023

The COVID-19 outbreak that emerged in December 2019 has had a dramatic impact on the global economy in which consumption, trade, and service activities have been greatly disrupted. Businesses across many sectors have experienced a severe decline in sales and jobs. But the magnitude and distribution of the pandemic greatly affected small firms, due to them being more financially constrained. This article provides a comprehensive assessment of the short-term impact of the COVID-19 pandemic on Algerian businesses. Based on a novel data set, the article shows how, beyond adjusting their labor costs and enforcing government-mandated lockdowns and social distancing, businesses could respond to the shock of COVID-19 thanks to the use of communication tools, such as the Internet and digital technologies, as well as the cooperation between companies. The article concludes that those firms that used Internet-based communication tools and those that built new ways of business cooperation and provided help to community during the lockdown showed higher survival rates after the lockdown.
Institutional geography: effects of physical distance on agency autonomy
Authors: Jacobsen Dag Ingvar , Trondal Jarle
Published: April 2023

Establishing government agencies outside ministerial departments is frequently justified by a need to safeguard agency autonomy. In addition to ‘formal agencification’, that is, erecting formal barriers between agencies and ministries, agencies are also frequently (re)located physically distant from ministries to both signal and strengthen agency autonomy. However, we know little of the effects of physical location and distance on agency autonomy. Using two large surveys from 2006 and 2016, this study examines how geographical location and distance affect agency autonomy. Our study establishes that agency autonomy is only weakly associated with physical location and distance, and is much less important than political salience. Whereas a conventional claim is that agency autonomy may be strengthened by physically (re)locating agencies at arm's length distance from the core executive, our study suggests that physical (re)location represents an ineffective administrative policy design-tool when applied to agency autonomy.

Points for practitioners

Physical distance between agencies and parent ministries is only remotely associated with agency autonomy. Physical location thus represents an ineffective design-tool if the purpose is to increase agency autonomy
Posttraumatic Stress Disorder and Alexithymia in Burn Patients
Authors: Fukunishi Isao , Chishima Yasunori , Anze Masaki
Published: April 2023

We examined symptoms of posttraumatic stress and alexithymia in a sample of 24 burn patients. Of these burn patients, those in the chronic phase (more than 10 months after the burn) indicated alexithymia more strongly. Among symptoms of Posttraumatic Stress Disorder, symptoms of avoidance and emotional numbing were also stronger in patients in the chronic phase. The manifestation of the alexithymic features was closely related to symptoms of avoidance and emotional numbing. These findings suggest the possibility that alexithymia as a state reaction may be evident when avoidance and emotional numbing appear among symptoms of Posttraumatic Stress Disorder.
A Public Health Laboratory Information System in Support of Health Emergencies: The Nebraska Public Health Laboratory COVID-19 Experience
Authors: Campbell Walter S. , Donahue Matthew , Williams Robin M. , McCutchen Emily , Broadhurst Jana , Schnaubelt Andy , Staffend Nicholas J. , Hinrichs Steven H. , Iwen Peter C.
Published: April 2023

Objectives:

Public health laboratories (PHLs) are essential components of US Public Health Service operations. The health information technology that supports PHLs is central to effective and efficient laboratory operations and overall public health response to infectious disease management. This analysis presents key information on how the Nebraska Public Health Laboratory (NPHL) information technology system evolved to meet the demands of the COVID-19 pandemic.

Materials and Methods:

COVID-19 presented numerous, unforeseen information technology system challenges. The most notable challenges requiring changes to NPHL software systems and capability were improving efficiency of the laboratory operation due to high-volume testing, responding daily to demands for timely data for analysis by partner systems, interfacing with multiple testing (equipment) platforms, and supporting community-based specimen collection programs.

Results:

Improvements to the NPHL information technology system enabled NPHL to perform >121 000 SARS-CoV-2 polymerase chain reaction tests from March 2020 through January 2022 at a sustainable rate of 2000 SARS-CoV-2 tests per day, with no increase in laboratory staffing. Electronic reporting of 62 000 rapid antigen tests eliminated paper reporting and extended testing services throughout the state. Collection of COVID-19 symptom data before specimen collection enabled NPHL to make data-driven decisions to perform pool testing and conserve testing kits when supplies were low.

Practice Implications:

NPHL information technology applications proved essential for managing health care provider workload, prioritizing the use of scarce testing supplies, and managing Nebraska’s overall pandemic response. The NPHL experience provides useful examples of a highly capable information technology system and suggests areas for additional attention in the PHL environment, including a focus on end users, collaboration with various partners, and investment in information technology.
Exploring the Challenges of Technology in Language Teaching in the Aftermath of the Pandemic
Authors: Stockwell Glenn , Wang Yijen
Published: April 2023

The impact of the COVID-19 pandemic has been varied, and while there was a clear upsurge in the use of technology in language and learning contexts during the worst lockdown periods, the long-term impact on technology usage remains to be seen. As has been widely noted, lockdowns forced teaching into remote modes, making technology indispensable. Many teachers found themselves struggling to use technologies with little or no experience or training, and often in spite of earlier resistance to using it. The affective barriers to using technology may have decreased somewhat, but other potential problems have arisen as well. There has generally been a narrow view about the effectiveness of technology use in language teaching and learning. During the pandemic, teaching often entailed using videoconferencing tools as a means of emulating face-to-face teaching, albeit inhibited by the limitations and the affordances of the technologies. While research into mobile learning prospered prior to the pandemic, long periods of lockdown saw them being used as little more than a backup for when other technologies experienced technical difficulties. In this paper, we discuss not only the often-cited positive effects of technology usage in language learning during COVID, but also the possible negative implications for how technology has come to be used and viewed by learners, teachers, and administrators. Suggestions for a potential way forward in this ‘aftermath’ of the pandemic are discussed, along with some guidelines for making the most of what we have learned about using technology for language learning in the future.
Color mixture model of seven primary color fiber grid blending and rotor spinning of full-color gamut mixed color yarn
Authors: Zhu Wenshuo , Xue Yuan , Chen Yourong
Published: April 2023

Based on the three-channel numerical control rotor spinning machine, this paper aims to develop a spinning technology that can control the yarn color in the full-color gamut. A seven primary color fiber grid blending mode and full-color gamut grid color mixture model containing 601 grid points were constructed. The mechanism of three-channel rotor spinning with coordinated regulation of three-channel feeding speed ratio, primary color fibers blending ratio and yarn color was constructed. The process theory of spinning the full-color gamut mixed color yarn based on the full-color gamut grid color mixture model formed by the grid blending of seven primary color fibers was developed. On this basis, 55 trial samples were selected from the full-color gamut grid color mixture model for spinning and knitting into fabric, and the evenness, strength, hairiness and other indicators of the yarn were tested.
Immersion and invariance sliding mode control with time-delay estimation for rigid spacecraft with uncertainties and actuator faults
Authors: Jing Chenghu , Du Haohao , Liu Yafeng , Yan Bingsheng , Liu Chunbo
Published: April 2023

This paper investigates the attitude control of rigid spacecraft with uncertainties and actuator faults. An immersion and invariance sliding mode control with time-delay estimation (IISMCTDE) is proposed to cope with uncertainties, disturbances, and actuator faults. First, time-delay estimation is utilized to reconstruct the total disturbances including uncertainties, disturbances, and actuator faults. Then, based on the time-delay estimation, an immersion and invariance sliding mode control (IISMC) scheme is developed to achieve accurate attitude tracking from the reconstructed knowledge. The proposed IISMCTDE can not only achieve finite-time convergence but also be simple and easy to operate. Simulations are provided to demonstrate the effectiveness of the proposed approach.
Differences of Organic Matter Types of High Maturity Marine Organic-Rich Shale from Wufeng-Longmaxi Formation: Implication for Shale Gas “Sweet Spots” Prediction
Authors: Li Minglong , Tan Xiucheng , Wang Gaoxiang , Li Yanjun , Xu Qiang , Zheng Jian , Yang Yang , Bai Xiaoliang , Ji Yubing
Published: April 2023

Based on the identification of visual kerogen assessment, a subdivision method of organic matter types was proposed. Combined with GR curve, the distribution was further studied, the relationship between shale reservoir parameters and organic matter types was analyzed, and the significance was discussed. The results show that the kerogen types of organic rich shale in the lower part of Wufeng-Longmaxi Formation in the south of the Sichuan Basin are mainly of type I, II1a and II1b, while type II2 and type III are not developed. In Wufeng Formation, the shale organic matter is mainly of type II1a and II1b. From Long111 to Long114, the shale displays a trend of “Type I-II1b-II1a-II1b”. Type I was characterized by higher TOC, porosity and gas bearing capacity of shale reservoirs than the other organic matter. The reservoir parameter of type II1a was better than type II1b, indicating that the organic matter type control on the quality of shale reservoirs. Type difference is closely related to the bio-precursors component, among which type I and type II1a are related to the content of planktonic algae, while type II1b is related to the content of benthic algae. This study provides a good reference for the subdivision of marine shale organic matter types and the evaluation and prediction of gas bearing properties.