bluuebunny/crossref_metadata_2025 huggingface dataset:
METAFUNCTION PATTERNS OF THE TOBA BATAK LANGUAGE
Authors: Samosir Hepnyi
Published: August 2018

This study aims at finding out the metafunction patterns of clauses of the Toba Batak Language. The data was gained from the speech of tulang (the mother’s brother) in delivering ulos saput at the Bataknese sari matua (an old person who died but he/she still has children who are unmarried) ceremony. The result shows that 74% of the clauses are patterned with Predicator, Complement, and Adjunct followed by Mood, whereas 26% of them are patterned with Mood followed by Predicator, Complement, and Adjunct.  The majority of the clause pattern is Predicator followed by Mood.  The most dominant theme is the Marked Topical Theme that reached 73% whereas 26% of them have Unmarked Topical Themes; the rest clause is imperative that has no theme. It can be concluded that  clauses in the Toba Batak Language are dominantly patterned by Predicator followed by Mood. The Mood consists of Finite preceding the Subject.  Residue itself mostly precedes Mood. The most dominant theme is the Marked Topical Theme in which the theme is not the Subject.

BAHASA INDONESIA ABSTRAK: Penelitian ini bertujuan untuk menemukan pola metafunction dalam bahasa Batak Toba.  Data peneltian ini adalah klausa-klausa yang disampaikan oleh tulang (saudara laki-laki dari ibu) ketika menyerahkan ulos saput dalam acara saur matua (orang Batak yang meninggal dalam kondisi sudah lanjut usia akan tetapi masih memiliki anak yang belum menikah). Hasil penelitian menunjukkan bahwa 74% klausa terdiri dari Mood yang  didahului oleh Predicator, Complement dan Adjunct, dan hanya 26% Mood mendahului Predicator, Complement, dan Adjunct.  Kebanyakan klausa dalam bahasa Batak Toba dibentuk dengan pola Predicator yang kemudian diikuti oleh Mood.  Theme yang paling dominan adalah Marked Topical Theme yang mencapai 73% sementara 26% merupakan Unmarked Topical Theme;  selebihnya merupakan kalimat perintah  yang tidak memiliki theme. Dapat disimpulkan bahwa  pola klausa dalam bahasa Batak Toba  adalah Predicator diikuti oleh Mood. Mood terdiri dari Finite yang mendahului Subjek.  Kebanyakan Residue mendahului Mood. Theme yang paling dominan adalah Marked Topical Theme dimana Theme bukan merupakan  Subjek.
PENGARUH PENERAPAN METODE CONTEXTUAL TEACHING AND LEARNING DALAM PENGAJARAN KOSAKATA BAHASA INGGRIS SISWA KELAS XI DI SMA NEGERI 33 JAKARTA [THE EFFECT OF IMPLEMENTING CONTEXTUAL TEACHING AND LEARNING ON TEACHING ENGLISH VOCABULARY IN GRADE 11 AT SENIOR HIGH SCHOOL 33 JAKARTA]
Authors: Atmawijaya Tito Dimas
Published: August 2018

This study aimed at investigating the effect of vocabulary teaching in procedure texts using Contextual Teaching and Learning (CTL). The research was carried out with the English classes in the Social Sciences program which was taught vocabulary using the Contextual Teaching and Learning (CTL) method while another class used a traditional method in teaching vocabulary.  The study used the quantitative data collected through the Post-Test after the treatment, questionnaires, and interviews. The data collected from the Post-Test were analyzed by implementing a t-test using SPSS 22 and counting average scores of both groups. The findings of the study indicate that teaching vocabulary using Contextual Teaching and Learning (CTL) method brings significant results. Furthermore, the results gathered from interviews and questionnaires confirmed that learners had a positive attitude towards CTL, as this method provided the students with a lot of activities which created a learning environment that was fun, enjoyable, and effective for improving the students’ vocabulary. Moreover, CTL also increased learners’ participation, scores, and collaboration.

BAHASA INDONESIA ABSTRAK: Artikel jurnal ini membahas efek pengajaran kosakata bahasa Inggris teks prosedur dengan menggunakan metode Contextual Teaching and Learning (CTL). Penelitian ini dilakukan pada suatu kelas IPS yang menggunakan CTL, sedangkan kelas lain menggunaan metode pengajaran tradisional. Metode penelitian ini adalah kuantiatif dengan jenis Post-Test Only. Data penelitian diambil dengan menggunakan Post-Test yang diberikan sehari dan tiga minggu setelah perlakuan kepada kedua kelas partisipan. Analisis hasil penelitian dilakukan dengan menggunakan rerata dan uji t dependen dan independen menggunakan SPSS 22. Analisis tersebut  menunjukkan peningkatan hasil yang signifikan pada kelas XI IPS 1 yang menerapkan metode CTL. Selain itu,  hasil temuan penelitian dari wawancara dan kuesioner menunjukkan bahwa metode Contextual Teaching and Learning (CTL) memberikan pengaruh positif dalam pembelajaran kosakata di kelas, yaitu meningkatnya partisipasi pemelajar, kemampuan kosakata reseptif dan produktif, dan kolaborasi di antara pembelajar.
PENDIDIKAN TENTANG MULTIKULTURALISME DALAM CERITA PENDEK KARYA PENULIS PRIBUMI AMERIKA [EDUCATING ABOUT MULTICULTURALISM USING A SHORT STORY BY A NATIVE AMERICAN AUTHOR]
Authors: Manggong Lestari
Published: August 2018

This paper discusses the contribution that reading a short story written by Native American author Sherman Alexie makes in the multicultural education. The story discussed is “This is What it Means to Say Phoenix, Arizona,” which displays cultural conflicts between Native Americans and Americans within the two main characters. In the discussion, the way such cultural conflicts are presented will be highlighted in terms of representing similar situations which can be reflected by students as individuals with multicultural identities. Cultural perceptions on the story will be discussed using the concept of multiculturalism as proposed by Menand (1995) and Native American literature by Parker (2004). Students’ perceptions on multiculturalism shown in this paper are taken from the students’ papers discussing multiculturalism, which are a required final assignment for the FSIP course.  This paper will then have its proposed final conclusion that in compromising multicultural identities, a strategy of tug and let loose is needed.

BAHASA INDONESIA ABSTRAK: Makalah ini membahas tentang kontribusi pembacaan cerita pendek (cerpen) karya penulis pribumi Amerika, Sherman Alexie, dalam pendidikan tentang multikulturalisme bagi mahasiswa di Program Studi Sastra Inggris Universitas Padjadjaran dalam Mata Kuliah Further Studies in Prose (FSIP). Cerpen yang dibahas berjudul “This is What it Means to Say Phoenix, Arizona,” yang di dalamnya terdapat konflik kultural antara Pribumi Amerika dan Amerika dalam diri dua karakter utamanya. Dalam pembahasan akan diperlihatkan bagaimana konflik kultural tersebut merepresentasi situasi sejenis yang dapat direfleksikan oleh mahasiswa, sebagai individu yang memiliki identitas kultural yang beragam. Pandangan-pandangan kultural yang beragam dalam cerpennya akan dibahas menggunakan konsep multikulturalisme Menand (1995) dan kesusastraan pribumi Amerika oleh Parker (2004). Pandangan-pandangan mahasiswa tentang multikulturalisme yang disampaikan dalam makalah ini bersumber dari makalah mahasiswa, yang merupakan tugas akhir untuk Mata Kuliah FSIP, yang membahas cerpen tersebut. Pembahasan pada makalah ini kemudian akan mengerucut pada suatu pandangan bahwa pada akhirnya diperlukan strategi tarik-ulur dalam upaya mengompromikan keragaman identitas kultural.
The Role of Dynamic Mathematics Software in the Development of Contextual Learning Environment during Teaching of the Parabola Concept
Authors: BALTACI Serdal , BAKİ Adnan
Published: August 2018

This research aims to investigate the role of the GeoGebra software as a tool to creat a contextual learning for the concept of parabola. Action research method was used in the research. Participants of the research are pre-service elementary mathematics teachers at third-grade in the undergraduate program. Data were collected through student worksheets, observations, field notes and interviews. The data were analyzed with qualitative methods in accordance with the REACT, a contextual learning strategy. As a result, it was determined that the GeoGebra software contributed to the relationships created in the learning environment since it allowed the preservice teachers to find opportunities to reinforce their previous knowledge. The GeoGebra software, on the other hand, facilitated application processes of the preservice teachers’ by helping those modelling geometric locations, which were given through icons and multiple representations. It was also observed that feedbacks provided by the software enabled a kind of communication among group members as they communicated, exchanged ideas and cooperated with each other. The software helped transferring between mathematical subjects and concepts.
Is Teaching a Lifelong Career? Reflections of English Teachers
Authors: ATMACA Çağla
Published: August 2018

This study aims to find out and compare pre-service and in-service English teachers’ preferences for choosing teaching profession and their opinions about whether teaching is a lifelong career. 308 pre-service English teachers and 50 inservice English teachers participated. The results showed that 240 pre-service English teachers and 44 in-service English teachers held positive opinions about teaching profession and thought that teaching is a lifelong career. However, 45 student teachers and 3 teachers held negative views. There were both similarities and differences between the pre-service and in-service participants in terms of their preferences for choosing teaching profession and their perspectives about teaching as a lifelong career. Some of the quotations of the participants are given to exemplify participant opinions because the participants were found to have various preferences for choosing teaching career like loving teaching, childhood dream, family encouragement, previous learning experiences, outer obligation or taking previous teachers as model.
La mujer emprendedora: identidad profesionaly factores culturales de género = Female entrepreneurs: professional identity and cultural gender factors
Authors: Sabater Fernández Carmen
Published: August 2018

Resumen. En el presente artículo se analiza la identidad de la mujer emprendedora mar­cada por factores culturales como la conciliación de la vida familiar y laboral y la adscripción de factores psicológicos y de personalidad basados en rasgos expresivo comunales. Se destaca la diferencia cultural que sigue asignando a la mujer las principales tareas de cuidado domé­stico y la proyección vital del emprendimiento femenino más orientado a compatibilizar los ámbitos personales y profesionales. Mediante un trabajo de campo basado en entrevistas en profundidad con 10 expertos y 20 mujeres emprendedoras de la Comunidad Autónoma de La Rioja, se demuestra cómo las propias mujeres exteriorizan el proceso del emprendimiento con rasgos comunes, más allá de las limitaciones, desde una perspectiva sintética de su rol de “persona” que busca su realización y gestiona su tiempo entre sus diferentes facetas vitales.Palabras clave: emprendimiento, mujer emprendedora, identidad femenina, sexismo, género.Abstract. This article analyses the identity of female entrepreneurs marked by cultural factors such as balancing work and family life as well as psychological and personality factors based on common expressive features. There is still a great cultural difference that continues to appoint women as responsible for the main tasks of home care and the vital projection of female entrepreneurship more oriented to combine personal and professional fields. This fieldwork based on in-depht interviews with 10 experts and 20 women entrepreneurs from the region of La Rioja demonstrates how women themselves externalize the process of entre­preneurship with common features, far beyond limits, from a synthetic perspective of their role as “individuals” looking for personal fulfilment and managing their own time in their dif­ferent life aspects.Keywords: entrepreneurship, female entrepreneurs, female identity, sexism, gender.
Foucault, eticidad y doble presencia: tipología en torno al cuidado de sí y del/a otro/a en mujeres académicas = Foucault, Ethics and Double Presence: Typology of Female Scholars on Self-Care and Care of the Other
Authors: Montes de Oca O’Reilly Alejandra , Yurén Teresa
Published: August 2018

Resumen. Se presentan los resultados de una investigación de carácter cualitativo sobre las representaciones en torno al cuidado de sí y el cuidado del/a otro/a que se observan al examinar el discurso de mujeres académicas de un estado del centro-sur de México que viven una doble presencia: en instituciones de educación superior y en sus hogares. Partimos de la constatación de que las políticas actuales que se aplican en la educación superior obligan a la realización de esfuerzos sostenidos para la construcción de ethos autónomos, especialmente por parte de las mujeres académicas en virtud de las tensiones que viven en su vida laboral y familiar. Consideramos que entre los factores que tienen incidencia en la doble presencia se encuentra una eticidad androcéntrica. Nos enfocamos en la dimensión del cuidado de sí y del cuidado del/a otro/a por sus implicaciones en la construcción del ethos de las mujeres académicas, mismas que parecieran generar dicotomías entre “ambos cuidados”. Con base en planteamientos de Foucault —así como en nuestros hallazgos— elaboramos una tipología con la que pretendemos hacer una contribución a las investigaciones sobre la doble presencia de las mujeres. Los tres tipos que definimos son: 1) bifurcada con respuesta normalizada, 2) bifurcada culpígena y 3) autónoma.Palabras clave: eticidad, doble presencia, mujeres, trabajo, Foucault.Abstract. This article describes the results of a qualitative research on the representa­tions around self-care and care of the other that are observed when examining the discourse of women scholars from a state in south-central Mexico. They respond simultaneously to educa­tion require sustained efforts for the construction of autonomous ethos, especially by female scholars, who live a tension between their work and family life. Among the factors that have an incidence in the double presence is an androcentric ethics. We focus on the dimension of self-care and care of the other due to its implications for the construction of the ethos of women scholars, which seem to generate dichotomies between “both cares”. Based on a Foucauldian approach —as well as on our findings— we developed a typology, with which we intend to make a contribution to research on the double presence of women. The three types that we define are: 1) bifurcated with normalized response, 2) guilt-ridden bifurcated and 3) autonomous.Keywords: ethics, double presence, women, work, Foucault.
Seminario “Mujer y deporte” INEF-Madrid. El acceso de las mujeres al deporte profesional: el caso del fútbol. Jornadas nacionales (Madrid, 19 y 20 de abril de 2018)
Authors: Gómez López Maite , Alfaro Elida , Vázquez Benilde
Published: August 2018

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Da criação coletiva ao processo colaborativo
Authors: Ary Rafael , Santana Mario
Published: August 2018

O intuito deste artigo é discorrer sobre os aspectos que aproximam e distanciam os processos criativos teatrais nomeados de criação coletiva e processo colaborativo, tendo em vista o contexto histórico de cada manifestação.
Dias Gomes, “Dr. Getúlio” e o teatro musical: engajamento, sonoridades e encenação no Brasil sob a ditadura militar
Authors: Paranhos Kátia Rodrigues
Published: August 2018

Este artigo aborda a importância política do teatro musical na obra de Dias Gomes. Tomando por base Dr. Getúlio, sua vida e sua glória (1968)/Vargas (1983), enfatizo como característica fundamental a mistura entre música, dramaturgia engajada e encenação. Examinar este musical equivale a revisitar, de certa forma, o momento vivido no Brasil, que essa peça denuncia e subverte, como nos possibilita uma aproximação com estilos narrativos diferenciados de representação do poder institucionalizado.
Exercícios políticos de imaginação – corporalidades na cena brasileira
Authors: Raquel Fernanda , Greiner Christine
Published: August 2018

Alguns exemplos artísticos são como documentos que convidam a meditar sobre modos de existir, de conviver, e de refletir sobre questões culturais. A partir da análise de duas experiências, de dança e de teatro, desenvolvemos uma argumentação acerca de corporalidades da cena brasileira que afirmam sua potência política. Ao exercitar suas singularidades, perturbam os significados de estar junto e tornam visível a instabilidade dos encontros.
Can Governments Earn Our Trust by Donald F. Kettl
Authors: Ford Michael R.
Published: August 2018

Kettl, D. F. (2017). Can governments earn our trust? New York, NY: Polity Press. $12.95 (paperback), ISBN: 978-1-509-52246-0
Reservoir Operation for Water Supply Considering Operational Ensemble Hydrological Predictions
Authors: Nohara Daisuke ,   Disaster Prevention Research Institute, Kyoto University Gokasho, Uji, Kyoto 611-0011, Japan, Hori Tomoharu
Published: August 2018

This paper presents approaches and case studies for the introduction of ensemble hydrological predictions to reservoir operation for water supply. Medium-term operational ensemble forecasts of precipitation are employed to improve the real-time reservoir operation for drought management considering longer prospects with respect to future hydrological conditions in the target river basin. Real-time optimization of the water release strategy is conducted using dynamic programming approaches considering ensemble hydrological predictions. A case study on the application of ensemble hydrological predictions to reservoir operation for water use is reported as an example, with a hypothetical target river basin whose hydrological characteristics are derived from an actual reservoir and river basin.
Comprehensive Etiological and Epidemiological Study on Acute Respiratory Infections in Children: Providing Evidence for the Prevention and Control of Childhood Pneumonia in the Philippines
Authors: Tamaki Raita , Tallo Veronica L. , Tan Alvin G. , Reñosa Mark Donald C. , Alday Portia P. , Landicho Jhoys M. , Inobaya Marianette T. , Saito Mayuko , Kamigaki Taro , Okamoto Michiko , Saito Mariko , Dapat Clyde , Dembele Bindongo P. P. , Mationg Mary Lorraine S. , Mondoy Melisa U. , Lupisan Socorro P. , Oshitani Hitoshi ,   Tohoku University Graduate School of Medicine 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan,   Research Institute for Tropical Medicine, Alabang Muntinlupa City, Philippines,   Nagasaki Women’s Junior College, Nagasaki, Japan
Published: August 2018

Childhood pneumonia has been the leading cause of morbidity and mortality for decades. Although substantial progress in the understanding of risk factors and etiology of pneumonia has been made, childhood pneumonia remains the major cause of death in children, accounting for 900,000 of the estimated 6.3 million child deaths worldwide in 2013. More than 90% of all episodes of clinical childhood pneumonia worldwide occur in low and middle-income countries. More effective and feasible interventions need to be developed and made widely available for such countries, including the Philippines. Comprehensive research, including etiological and epidemiological studies for assessments of risk factors and thereby, intervention studies to reduce the impact of childhood pneumonia are required in hospital settings, as well as community settings, consistently. A research project entitled “comprehensive etiological and epidemiological study on acute respiratory infections in children: providing evidence for the prevention and control of childhood pneumonia, the Philippines” was conducted under SATREPS (Science and Technology Research Partnership for Sustainable Development), which is a funding scheme to promote international joint research focusing on global issues. This project was implemented in four sentinel hospitals, with some community settings, in the Philippines between April 2011 and March 2017, incorporating five sub-components: etiological study, disease burden study, risk factor analysis, intervention study, and its evaluation. In this paper, we introduce the research project of SATREPS focusing on the methodologies, progress, and obtained evidence.
Effectiveness of the Submersible Embankment in Haor Area in Bangladesh
Authors: Mahtab Mohammad Hossain , Ohara Miho , Rasmy Mohamed ,   International Centre for Water Hazard and Risk Management (ICHARM), Public Works Research Institute (PWRI) 1-6 Minamihara, Tsukuba, Ibaraki 305-0803, Japan,   National Graduate Institute for Policy Studies (GRIPS), Tokyo, Japan
Published: August 2018

The north-eastern part of Bangladesh is very productive for agriculture and fishing, and the region involves several depressed (haor) areas. Flash floods during the pre-monsoon period bring devastating damage to agriculture in the haor region recurrently. To protect crops from flash floods, the Bangladesh Water Development Board constructed several ring-type submersible embankments. In this research, we have investigated the effectiveness of submersible embankments in controlling flash flooding in the Matian and Shanir haors in the Sunamganj district. A two-dimensional rainfall runoff inundation model was applied considering several scenarios for simulating heavy flash flood events in 2004, 2010, and 2016. Without an embankment, the river overflow would have entered the Matian haor 3 days, 22 days, and 9 days earlier in 2004, 2010, and 2016, respectively, whereas it would have been 7 days and 23 days earlier in 2004 and 2010 for the Shanir haor. The event in 2016 was successfully stopped by the Shanir haor embankment. To avoid river overflow entering into the Matian and Shanir haor completely, the embankment height must be elevated further by 1 m and 0.7 m, respectively. Providing proper drainage facilities for the accumulated rain water inside the hoar is still an important issue for protecting the crops effectively.
Cockroach Theory of Organizational Sustainability and Scalability - Detailed Study on Evidence Based on BOP Approach
Authors: Raj Keerthan , Aithal P. S.
Published: August 2018

The question of survival and sustenance are at the very foundation of every individual or organization.  There are various factors that are essential for growth and sustenance of companies. There has been many research studies undertaken to gauge the success factors or to breakdown the components and study success in detail. Especially so, it gains even more importance when companies are serving the markets where consumers have very low incomes and have several unmet needs. Companies serving the base of the pyramid markets need relatively unique strategies and value propositions for success. The base of pyramid came into forefront when management thinkers C K Prahalad and Staurt L. Hart, formulated the “Bottom of the Pyramid” theory in a 2002 article about how businesses can help the poor while still able to make a profit. They noted that there was little competition among the millions of the poor, who essentially live in a world of non consumption. Through low prices, new business models and innovative products, and inclusive value creation corporations along with the help of nongovernmental organizations (NGOs) and local governments, could make money and do good for the larger cause by tapping this underserved market. It has been the belief of many that BOP consumers are typically characterized by several unmet needs, it could range from food, sanitation, transport, communication, and connectivity. It is also interesting to note that in several BOP markets where are overlapping needs not necessarily following the need hierarchy.  Information and communication technology businesses have been able to occupy a larger share of the BOP consumer’s wallet than even basic needs such as sanitation or electricity. What then prompts these consumers and how can businesses reach out to these segments in a phased successful manner. This paper develops the concept, postulates, explanations, theoretical model, and business case based proof on Cockroach Theory of Organizational sustainability and scalability by considering BOP business companies performance evidence. The study also discusses the applicability of this theory and its frameworks on companies and their business models focusing on BOP sectors along with the limitations.
Academic Orthopaedic Leadership: Current Challenges and Lessons Learned
Authors: Salazar Dane H. , Herndon James H. , Vail Thomas P. , Zuckerman Joseph D. , Gelberman Richard H.
Published: August 2018

Health-care reform, market competition, cost containment, and pressure for productivity have dramatically impacted the practice of orthopaedic surgery and academic surgical training. Orthopaedic leaders and training programs are striving to identify and solve these contemporary challenges. Herein, we focus on 4 areas that currently pose important challenges to modern orthopaedic surgical departments and academic hospital systems, including the demanding and evolving skill sets that are required of physician leaders, the effects of the changing medical-legal environment on academic medicine, the impact of increased clinical productivity emphasis on surgical education, and departmental leadership transitions.
Extensor Mechanism Reconstruction with Use of Marlex Mesh
Authors: Abdel Matthew P. , Salib Christopher G. , Mara Kristin C. , Pagnano Mark W. , Perry Kevin I. , Hanssen Arlen D.
Published: August 2018

Background:

Disruption of the extensor mechanism after total knee arthroplasty (TKA) is debilitating, and the reported results of numerous reconstructive options have varied. We previously reported the early results of 13 patients who underwent reconstruction of the extensor mechanism with use of Marlex mesh. The purpose of the current study was to assess results in a larger cohort of patients, with an emphasis on the survivorship of the mesh, clinical results, and complications.

Methods:

During the period of 2000 to 2015 at a single tertiary care academic institution, 77 patients (77 TKAs) underwent reconstruction with use of Marlex mesh for an extensor mechanism disruption (27 quadriceps tendon disruptions, 40 patellar tendon disruptions, and 10 patellar fractures). The mean patient age at the time of reconstruction was 65 years; 70% of the patients were female. The mean body mass index was 35 kg/m2. The mean follow-up was 4 years. Eighteen (23%) of the patients underwent mesh reconstruction with the primary TKA in place, and 59 (77%) had mesh reconstruction at the time of revision TKA. The mean time between disruption and reconstruction was 7 months. Twenty (26%) of the patients had previously undergone attempted extensor mechanism reconstruction at outside institutions.

Results:

Sixty-five of the 77 mesh reconstructions were in place at the time of the latest follow-up. Twelve patients experienced a failure that required mesh revision: 5 for patellar tendon rupture, 5 for quadriceps tendon rupture, and 2 for symptomatic lengthening. Four additional patients with mesh failure were treated nonoperatively with bracing. The 2-year survivorship free of mesh revision was 86% for patients with no prior reconstruction and 95% for patients with previous reconstructions of the extensor mechanism that did not involve Marlex mesh. Knee Society Score (KSS) results significantly improved following reconstruction (p < 0.001). Extensor lag improved by a mean of 26°, with mean postoperative extensor lag measuring 9° (p < 0.001).

Conclusions:

Reconstruction of the extensor mechanism with use of Marlex mesh is a viable option in patients with catastrophic disruption after TKA. At the time of the latest follow-up, 84% of the mesh reconstructions were in place and the functional outcomes were excellent, with mean improvement in extensor lag of 26°. Extended follow-up is required, but the results of this large series with a mean follow-up of 4 years are encouraging.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Sex-Specific Differences in Psychological Response to Injury and Return to Sport Following ACL Reconstruction
Authors: Sims Mary , Mulcahey Mary K.
Published: August 2018

* Recent literature has focused on the psychological aspects associated with recovery that may affect outcomes following anterior cruciate ligament (ACL) reconstruction.

* Psychological factors such as self-efficacy, locus of control, athletic identity, and fear of reinjury have been shown to impact the recovery and rehabilitation process.

* Men and women display different psychological responses to injury; men report greater self-efficacy postoperatively and a loss of overall self-worth with injury, whereas women are self-directed and exhibit greater anxiety concerning an injury’s impact on their lives and a loss of physical self-worth with injury.

* Preoperative identification of sex-specific psychological factors that are known to affect return to sport following ACL reconstruction may contribute to improved return to sport and quality of life.
Alcohol Expectancy-Adolescent Questionnaire (AEQ-AB): Validation for portuguese college students
Authors: Almeida Leandro S. , Pérez Fuentes María del Carmen , Casanova Joana R. , Gázquez Linares José Jesús , Molero Jurado María del Mar
Published: August 2018

Excessive alcohol consumption by college students is being recognized more and more, and its negative effects justify the implementation of prevention programs. Positive expectancies of alcohol are frequently acquired in adolescence and assume an important role in young-adult consumption patterns. This paper describes validation of the brief version of the Alcohol Expectancy-Adolescent Questionnaire (AEQ-AB) carried out with a sample of 317 freshman-year college students at a public Portuguese University. Results of confirmatory factor analysis, invariance and internal consistency showed some difficulties in the internal structure of the questionnaire. The two-factor model did not fit because no factor emerged to represent the negative expectation items. A single-factor structure was assumed and its invariance by gender was confirmed, as well as good internal consistency. The validity criterion showed positive and negative correlations with several variables depending on whether they were positively or negatively related to alcohol consumption. The oldest students and students drinking alcohol from early ages had the lowest expectancy of positive effects of the use of alcohol. With regard to academic performance, freshmen with a high GPA showed strong expectancies for the positive effects of alcohol. Positive correlations have been observed between positive alcohol expectancy and consumption levels. Further studies are necessary to include a negative dimension in the measure of expectancies of alcohol consumption.
Regulation of MicroRNAs by Phytochemicals: A Promising Strategy for Cancer Chemoprevention
Authors: Babashah Sadegh , Bakhshinejad Babak , Birgani Maryam Tahmasebi , Pakravan Katayoon , Cho William C.
Published: August 2018

A growing body of evidence suggests that phytochemicals are potentially able to affect a
variety of cellular processes, including proliferation, apoptosis, cell-cycle control, angiogenesis, inflammation,
and DNA repair. Phytochemicals may typically play pleiotropic regulatory roles in cancer
cells. Chemoprevention, which can be achieved by using these natural agents, has emerged as a
helpful strategy to manage a variety of malignancies. With regard to cancer-associated chemopreventive
mechanisms, phytochemicals can act by modulating microRNAs (miRNAs) and their target
genes. This review aims to present an overview of recent findings on the effects of some wellcharacterized
bioactive phytochemicals on miRNA regulation in different cancer types. The potential
use of these phytochemicals for the chemoprevention and treatment of cancer is also discussed.
Autophagy as a Potential Therapeutic Target in Breast Cancer Treatment
Authors: Lisiak Natalia , Toton Ewa , Rybczynska Maria
Published: August 2018

One of the crucial reasons of breast cancer therapy failure is an impairment of mechanisms
responsible for metabolism and cellular homeostasis, which makes it difficult to foresee the
response to the treatment. Targeted therapy in breast cancer is dictated by the expression of specific
molecules such as growth factor or hormone receptors. Many types of breast cancer exhibit different
abnormalities in the apoptotic pathway, which confer the resistance to many forms of chemotherapy.
Because of the fundamental importance of autophagy in the development and progression of cancer
and its ability to affect treatment response, there has been an immense research on molecular regulation
and signal transduction mechanisms that control this process. Here, we summarize the present
knowledge concerning different breast cancer treatment strategies using drugs approved for the
treatment of different breast cancer molecular subtypes with targeting pathways and factors associated
with autophagy modulation/ regulation.
Modulating Interleukins and their Receptors Interactions with Small Chemicals Using In Silico Approach for Asthma
Authors: Majumdar Sreyashi , Ghosh Abhirupa , Saha Sudipto
Published: August 2018

Asthma is a complex, heterogeneous, airway inflammatory disorder broadly classified into
atopic (IgE mediated) and non-atopic asthma. Monoclonal Antibodies (MAbs) and small chemical Protein-
Protein Interaction Modulators (PPIMs) are targeted against interleukins (ILs), which play a critical
role in asthma. Many MAbs are targeted against ILs and IgE. Anti IgE MAb (Omalizumab) and Anti IL-
5 MAbs (Mepolizumab, Reslizumab) have only been approved by FDA. Most of the MAbs including
Tracolizumab, Lebrikizumab, Anrukinzumab (Anti IL-13 MAb), and Brodalumab (Anti IL-17 MAb) are
in different phases of clinical trials. Pascolizumab (Anti IL-4 MAb), however, has failed. These MAbs
are expensive and may render adverse immune response. Thus, small chemical modulators targeting ILs
and their receptors (IL-Rs) are being exploited computationally and further validated experimentally.
The complex ILs and IL-Rs available in PDB are best suited for these types of studies. A large number
of small chemical modulators against Protein-Protein Interactions (PPIs) have been compiled in a few
databases like TIMBAL, 2P2I DB and IPPIDB. Small chemical libraries are used for virtual screening to
find novel modulators targeting IL-R binding interface on IL. Molecular dynamic simulations have been
further used for disruption mechanism and kinetic studies. IL-2/IL-2R was targeted with clinically tested
small molecule modulators like SP4206, and IL-2 levels were known to increase in non-atopic asthma.
In the absence of experimentally known modulators against atopic asthma, computational tools are being
explored. For example, IL-33 is a target for atopic asthma where IL-33 and its receptor complex structure
is available in PDB. In summary, small chemical modulators against ILs are a complementary approach
to MAbs and computational tools have been used for identifying these modulators for asthma.
Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study
Authors: Raposo Luís , Martins Sandra , Ferreira Daniela , Guimarães João Tiago , Santos Ana Cristina
Published: August 2018

Background:

The prevalence of thyroid dysfunction and autoimmunity in the Portuguese population has not yet been estimated. However, the national prevalence of the metabolic syndrome remains high. The association of thyroid pathology with cardiovascular risk has been addressed but is still unclear. Our study aimed to evaluate the prevalence of thyroid dysfunction and autoimmunity and to assess the associations of thyroid-stimulating hormone and thyroid hormones and antibodies with metabolic syndrome, its components, and other possible determinants in a national sample.

Material and Methods:

The present study included a subsample of 486 randomly selected participants from a nationwide cross-sectional study sample of 4095 adults. A structured questionnaire was administered on past medical history and socio-demographic and behavioural characteristics. Blood pressure and anthropometric measurements were collected, and the serum lipid profile, glucose, insulin, hs- CRP, TSH, FT4, FT3 and thyroid antibodies were measured.

Results:

In our sample, the prevalence of hypothyroidism, hyperthyroidism and undiagnosed dysfunction was 4.9%, 2.5% and 72.2%, respectively. Overall, the prevalence of positivity for the thyroid peroxidase and thyroglobulin antibodies was 11.9% and 15.0%, respectively. A positive association was found between free triiodothyronine and metabolic syndrome (OR: 2.019; 95% CI: 1.196, 3.410). Additionally, thyroid peroxidase antibodies had a negative association with metabolic syndrome (OR: 0.465; 95% CI: 0.236, 0.917) and its triglyceride component (OR: 0.321; 95% CI: 0.124, 0.836).

Conclusion:

The prevalence of undiagnosed thyroid dysfunction and autoimmunity was high. Thyroid peroxidase antibodies were negatively associated with metabolic syndrome and its triglyceride component, whereas the free triiodothyronine level was positively associated with metabolic syndrome.
Experimental Study of Thermal Restraint in Bio-Protectant Disaccharides by FTIR Spectroscopy
Authors: Magazù S. , Calabrò E. , Caccamo M.T.
Published: August 2018

Background:

In the present paper, InfraRed (IR) spectra on water mixtures of two homologous disaccharides, i.e. sucrose and trehalose, as a function of temperature have been collected.

Methods:

In particular, IR spectra were registered, in the spectral range from 4000 cm-1 to 400 cm-1, to investigate the thermal response of the water mixtures of two homologous disaccharides, through positive thermal scans, i.e. by increasing the temperature from the value of 25°C to the value of 50°C. The OH-stretching region has been analyzed by means of two simple and straightforward procedures, i.e. by evaluating the shift of the intramolecular OH stretching center frequency and the Spectral Distance (SD).

Result and Conclusion:

Both the analyses indicate that trehalose water mixture have a higher thermal response than that of the sucrose-water mixture.
Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study
Authors: Kolovou Vana , Diakoumakou Olga , Papazafiropoulou Athanasia K , Katsiki Niki , Fragopoulou Elisabeth , Vasiliadis Ioannis , Degiannis Dimitris , Duntas Leonidas , Antonopoulou Smaragdi , Kolovou Genovefa
Published: August 2018

Background:

The influence of biomarkers in human lifespan has been investigated but with no clear results yet.

Materials and methods:

Lipids, Uric Acid (UA), Adiponectin (ADIPOQ), Insulin-like Growth Factor (IGF-1), cholesteryl ester transfer protein (CETP) and angiotensin-converting enzyme (ACE) proteins, as well as CETP, ADIPOQ, insulin-like growth factor binding protein-3 (IGFBP3) and ACE-gene polymorphisms were evaluated in 149 Greek individuals. The Long-Lived Families (LON) (n=84) comprised of 3 generations: long-lived aged ≥90 years (P), offspring (FL1) and their grandchildren (FL2), while the Short-Lived Families (EAD) (n=65) where both parents died <75 years, comprised of 2 generations: middle-aged (FD1) and children (FD2).

Results:

Serum CETP and IGF-1 levels were lower, whereas AdipoQ concentrations were higher in P compared with FL1 and FL2 members (CETP: p = 0.03 for both comparisons; IGF-1 p < 0.001 for both comparisons and ADIPOQ: p = 0.001 and p = 0.004, respectively). Furthermore, serum triglycerides, UA and glucose concentrations were higher in FD1 compared with FD2 subjects (p=0.001, 0.02 and ≤0.001, respectively). In FD2 and FL2, CETP levels were lower in individuals with B2B2 compared with B1B1 genotype (p=0.007). Additionally, ACE concentrations were higher in individuals with DD compared with II genotype in both Families (p=0.001). After adjustment for age and gender, CETP levels were lower in P and FL2 individuals with B2B2 compared with the B1B1 genotype (p=0.004 and 0.007, respectively).

Conclusion:

Increase serum TGs, UA and GL concentrations were higher in the middle-aged individuals compared with their children in families independently of their lifespan. The serum adiponectin concentration was the highest in the oldest old individuals implying beneficial influence on lifespan. Independently of family’s lifespan history, the youngest individuals with CETPB2B2 genotype, compared with individuals with CETPB1B1 genotypes, had lower serum CETP concentrations. The knowledge of the unfavourable gene(s)influencing human lifespan may be helpful in encouraging individuals to follow healthier lifestyle habits and better control their high-risk biomarkers.
The Effect of Microwave Oven Drying on the Compressive Strength of Type III and IV Dental Stones at Different Time Intervals
Authors: Dulaimi Suha Fadhil , Kanaan Sabiha Mehdi
Published: August 2018

Background:

Dental stone cast needs 24 to 48 hours to evaporate excess water and acquire enough strength for manipulation. The microwave oven is used to save time by drying and disinfecting stone casts.

Objectives:

The aim of the present study is to evaluate the effect of microwave oven drying on the compressive strength of Type III and Type IV dental stone in three time intervals-3 hours, 5 hours and 24 hours after pouring.

Methods:

The study involved 120 samples: 60 samples for each type of dental stone. Thirty samples were subjected to air drying at 3, 5 and 24 hours) and 30 samples were dried in the microwave oven at 2450 MHZ -900 W for 150 seconds (at 3, 5 and 24 hours). The samples were tested by unconfined compression machine, with a 2000 kg proving ring at cross-head speed of 1 mm/min.

Results:

For the Type III dental stone drying at 3 hours, microwave radiation causes a significant increase in compressive strength and shows the highest score (mean 125 kg/cm); however, at 5 hours no significant difference was observed. However, at the 24 hour time interval, microwave drying causes significant reduction in the mean (100 kg/cm)p<0.01 .For the Type IV dental stone testing at all-time intervals (3,5, 24 hours), a significant reduction (p<0.05) in mean values was shown(80,85,87 respectively).

Conclusion:

Microwave oven drying increased the compressive strength of Type III dental stone at the 3 hour time interval from pouring, while microwave drying at the 5 hour interval had no significant effect; and at 24 hour the compressive strength of the dental stone was reduced. For the Type IV dental stone microwave drying had a detrimental effect on compressive strength at all-time intervals.
Sensory Evaluation of Yogurt-like Set and Yogurt-like Drink Produced by Indigenous Probiotic Strains for Market Test
Authors: Pamungkaningtyas Fathyah Hanum , Mariyatun Mariyatun , Kamil Rafli Zulfa , Setyawan Ryan Haryo , Hasan Pratama Nur , Wiryohanjoyo Devin Varian , Nurfiani Sri , Zulaichah Eni , Utami Indyah S. , Utami Tyas , Rahayu Endang S.
Published: August 2018

Lactic acid bacteria have been isolated from several Indonesian indigenous fermented foods and screened for the potential strains as probiotic candidates. The aim of this study was to evaluate sensory properties and respondents’ preference of yogurt-like set and yogurt-like drink with various Indonesian indigenous probiotic strains produced by dairy industry. Indigenous probiotics of Lactobacillus plantarum MUT-7 and Lactobacillus plantarum DAD-13 were used to produce yogurt-like set and yogurt-like drink. Family perception toward yogurt-like drink was performed in Yogyakarta involving 100 family members. The yogurt-like products were also compared to yogurt containing commercial Lactobacilus bulgaricus and Streptococus thermophilus or commercial yogurt produced by dairy company. Several sensory evaluation toward sensory properties and panelist’s preference were performed in different cities.  The result showed that the indigenous probiotic L. plantarum DAD-13 and L. plantarum MUT-7 were potential to be used as a starter culture for the production of yogurt-like set and yogurt-like drink. The combination of indigenous probiotics and indigenous lactic acid bacteria S. thermophilus DAD-11 resulted in better sensory properties of yogurt set compared to combination of L. bulgaricus and S. thermophilus.
Development of the Traditional Tape Ketan Into Probiotic Drink
Authors: Rahayu Endang S. , Nursiwi Asri , N Bedri Sekar , Supriyanto Supriyanto
Published: August 2018

Probiotics are living microorganism which give health benefit when consumed. Probiotic needs a ‘vehicle’ for their specialized actions in gastrointestinal tract. In this research, tape ketan was used as ‘vehicle’. The objective of this research was to produce probiotic tape ketan powder as an ingredient of functional beverage. Tape ketan used in this research was made by fermentation of glutinous rice with ragi and supplemented with Lactobacillus plantarum Dad 13 (107CFU/g glutinous rice). Probiotic powder was obtained using spray dryer with inlet temperature of 90oC with the addition of 35% maltodextrin. The powder was reconstituted into water with addition of pectin and sucrose. The results showed that viability of lactic acid bacteria and L. plantarum decreased after drying (0.82 and 0.90 log cycle respectively) with viable count from 1.29x1010 CFU to 1.96x109 CFU for lactic acid bacteria and from 1.04x1010 CFU to 1.32x109 CFU for L. plantarum. To obtain probiotic tape ketan beverage, 20% tape ketan powder (w/v), 0.5% pectin (w/v) and 4% sucrose (w/v) were reconstituted. Tape ketan powder which was supplemented with probiotic Lactobacillus plantarum Dad 13 is potential as an ingredient of functional beverage (from the viability after drying).
An Expert System Using Certainty Factor for Determining Insomnia Acupoint
Authors: Gunawan Elizabeth Paskahlia , Wardoyo Retantyo
Published: August 2018

In treating insomnia patients, acupuncturists who are not always in their clinics trust their patients to their assistants but because of their assistants limited knowledge, their assistants can not determine the right acupoints. Therefore, an application that able to store their knowledge about insomnia disease treatment is needed so that their assistants can handle the patients like they do.In this research, an expert system application using certainty factor method to determine the acupoint in dealing with insomnia disease was built. This research used certainty factor to accommodate uncertainty about symptoms and rules. The mechanism of certainty factor on symptoms used a measure of increased belief (MB) and a measure of increased disbelief (MD).The built expert system resulted acupoints based on symptoms experienced by insomnia patients. Accuracy value produced by the system that used certainty factor for determining acupoint dealing with insomnia is 0.933. It showed that the acupoint produced by the system is 93.3% relevant according acupuncturist expertise in treating insomnia patients.