bluuebunny/crossref_metadata_2025 huggingface dataset:
APPLYING PHET SIMULATIONS IN TEACHING MECHANICAL OSCILLATIONS AND WAVES AT SECONARY SCHOOL
Authors:   Plovdiv University Paisij Hilendarski, Plovdiv, Petrova Hristina , Atanasova Hristina ,   Secondary school „Chernorizets Hrabar“, Plovdiv
Published: August 2023

STEM educational technology is attracting more and more educators from different countries around the world. It is innovative educational technology. The 21st century competences such as creativity, communication, collaboration and critical thinking are formed in its application. Educational simulations are a basic didactic tool of STEM technology in teaching natural sciences and in particular Physics. Тhe Physics Education Technology (PhET) project creates useful simulations for teaching and learning Physics. They are freely available on the PhET web site: https://PhET.colorado.edu. Some ideas for the application of PhET simulations in the study of mechanical oscillations and waves are presented. They are interactive, animated and visual. As a result students develop permanent and profound knowledge about them and about related quantities and laws.
INCREASING THE STUDENTS’ MOTIVATION FOR READING BY ENGAGING THEIR SOCIAL INTELLIGENCE – READING OUTSIDE THE CLASSROOM DURING THE ENGLISH LANGUAGE LESSON
Authors:   First English Language School, Sofia, Karapeeva Latinka
Published: August 2023

The article presents a new way of engaging students from different schools ages and interest in active meaningful reading combined with an attempt to further develop social competence. Modern teaching methods include more and more electronic means that aim to match the interests of the internet born students and the new environment at home and at school. All this does not help develop social intelligence. The goal of this initiative is to stimulate all senses, to provoke thinking, to engage different skills – reading, listening, writing and to develop social skills. The traditional environment – the classroom, in this case is replaced with outdoor activities centred around reading, which is a basic skill, a key to improving all other competencies. Students from different age groups (eighth and fifth grade), with different interests (languages and music) and different abilities participate actively in achieving the goals of their groups. Through the reading task cognitive thinking is stimulated. Working in groups expands the students’ social intelligence, which includes the individual’s understanding of a particular situation and that person’s interaction with other people. The eighth-grade students use compensatory methods to engage and hold the attention of the younger students, incorporating compensatory skills – artistic reading, voice changing. The younger students put effort in understanding the text and guessing where it comes from. Later they show their gratitude by giving an improvised classical music concert in the open space of the schoolyard.
USING THE INTERNET IN THE PRIMARY SCHOOL ENGLISH CLASSROOM
Authors:   St. Cyril and St. Methodius University of Veliko Tarnovo – Branch Vratsa, Gruncheva Larissa
Published: August 2023

Тhis paper looks at the application of the Internet in the TEFL in the primary school and presents a model for using the Internet in the English classroom. Attention is paid to modern digital technologies, which are becoming an invariable part of Bulgarian education and play an increasingly important part in the education of primary school learners. Until recently primary school age was considered a „low tech“ segment of a child’s life and today it is the beginning of their digital literacy. The paper also examines the role of the Internet in TEFL both as providing different types of visualization and teaching resources, and as providing enhanced learning experiences. While the first is the modern version of the blackboard and chalk, the second is an important methodological innovation that makes possible greater individualization in TEFL according to the needs of the individual learner, more social interaction through linking students together and reflection on the nature of language as an always changing system of communication. A model for using the Internet in the primary school English classroom is presented along with game-like activities tailored to the age and language level of the primary school learners. The paper contains conclusions about the role of adults for finding a balance between the benefit of exposure to technology and becoming over-saturated with access to it. The Internet, as a source of digital resources and enhanced learning experiences for primary school learners cannot replace the teacher, nor can it replace classroom teaching.
PROJECT FORM OF WORK FOR DESIGN AND DEVELOPMENT OF ELECTRONIC GAMES FOR STUDENTS AS A WEB-BASED SERVICE
Authors:   Professional Technical High School, Burgas, Zheleva Petya
Published: August 2023

The development of information technologies helps to build modern games that support learning. Computer games are typically executable programs or web-based applications in which the software platform runs the game content. The characteristics of serious computer games that make them effective for educational purposes, such as being motivating, engaging and fun, are often associated with active learning. Active learner participation is one of the inherent strengths of computer games. Serious computer games provide an environment for active learning. Computer games are integrated into learning in the form of an innovative educational paradigm. This is the so-called game-based learning, where computer games are a medium for delivering learning content.
APRIL 22 – WORLD EARTH DAY. OUR PLANET, OUR HOME
Authors:   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev, Baneva Elena
Published: August 2023

In this report, Ms. Baneva wants to give publicity to the problem of pollution of the planet Earth and the climate. This day has been celebrated since 1970 in the USA and Canada, and since 1990 has been declared international. In Bulgaria, this day has been celebrated since 1993, and aims to unite people around the idea of protecting the environment and crime. The fight against climate change must be persistent and decisive, but only the actions of people can show whether we will succeed. Climate change is one of the biggest problems in recent years and many global organizations are constantly discussing solutions to reduce this problem. All destruction in nature, targeted pollution and climate change lead to the destruction of the planet’s biodiversity. World Earth Day was held in the group for a full-day organization of the school day 2nd grade First Primary School. „Cyril and Methodius“, Gotse Delchev.
ТHE IKEBANA – OPPORTUNITY TO IMPROVE STUDENTS’ MIND AND IMAGINATION DURING CLASS WORK
Authors:   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev, Materova Ana
Published: August 2023

If you attract the attention of all students with something that activates all their senses, imagination and creative thinking, they could learn new skills better and follow instructions more easily. Innovative method of making Ikebana allows students through their personal work to make something that will always be useful to them. Making Ikebana is unique way to develop students’ dexterity and imagination and stimulate their learning and creative thinking. Making Ikebana helps students gain patience, dexterity and aesthetics during class work. Making Ikebana develops students’ creativity, imaginations and desire during class work. Making Ikebana makes students happy, satisfied and motivated.
TEAM CREATIVE GAME
Authors:   Kindergarten „Edinstvo Tvorchestvo Krasota“, Vratsa, Bogdanova Veneta , Doncheva Tsvetomila ,   Kindergarten „Edinstvo Tvorchestvo Krasota“, Vratsa
Published: August 2023

This publication aims to present practical experience of applying innovative technologies and their place in the educational process. Emphasis is placed on the need to apply innovations in the field of teaching methods and techniques in preschool education. Creative games with LEGO® Education support logical thinking, develop cognitive and analytical skills. They allow children to group, rearrange, tell, and build confidence in their own abilities. Creative play with LEGO® in the educational direction „Fine Art“ is a unique experience for children of the second age group „Usmivka“ and an incomparable challenge for their teachers. This innovation is part of the activities of the National Program „It’s nice at Kindergarten“, and its result is of particular importance for the acquisition of a set of competencies needed in preschool age.
THE HALF AND THE THIRD – BINARY CONTINUITY LESSON IN THIRD AND FIFTH GRADES
Authors:   „St. Cyril and St. Methodius“ First Primary school, Gotse Delchev, Petkov Lina , Maltyazova Maya ,   „St. Cyril and St. Methodius“ First Primary school, Gotse Delchev, Atanasov Valentin ,   „St. Cyril and St. Methodius“ First Primary school, Gotse Delchev
Published: August 2023

This is a binary mathematics lesson to reinforce the concepts of halves and the thirds. The new knowledge that third graders gain in the lesson is their introduction to the appropriate notation of halves and thirds with fractions. This is also the continuity between third and fifth grade. The lesson combines knowledge and skills in mathematics, Bulgarian language and literature, fine arts, technology, and entrepreneurship. The pre-project activity „The Half and the third“ gives a visual image of these concepts. Hands-on teamwork activities in a lesson are a great way to represent the concepts with real objects and a way to work with units of measurement that have been learned. Students should present what they have already learned about halves and thirds with a paper and cardboard presentation in the shape of flowers. They present drawn geometric shapes that are divided into two or three equal parts. In some of the shapes one of the two /three/ equal parts is colored. This is the problem situation – how to label this part in the presentation? The task of the fifth-grade teacher is to introduce fractions one-half and one-third of something whole through demonstration and with mathematical expression that is understandable to third graders. To show, explain and write down the fractions 1/2 and 1/3. The lesson ends with an emotional story about the symbolism of flowers by the school psychologist.
How Ready Are Managers Of Preschool Education Institutions For New Crises?
Authors: KAMIŞLI Halil , TOKEL Aytaç
Published: August 2023

Önümüzdeki yıllarda yaşanılabilecek krizlerde, eğitim sürecinin kesintisiz olarak ve arzu edilen düzeyde devam etmesi için tüm kurumların hazırlıklı olması kaçınılmaz bir zorunluluktur. Bu doğrultuda bu kurumları yöneten idarecilere
büyük görevler düşmektedir. Bu görevlerini yerine getirmede sahip oldukları kriz yönetim becerilerinin büyük önemi vardır. Mevcut yöneticilerin bu becerilerden yoksun olması, olası kriz durumunda eğitim sürecini sekteye uğratabileceğinden,
yöneticilerin mevcut kriz yönetimi becerilerinin belirlenmesi, olası eksiklerin giderilmesi açısından önem teşkil etmektedir. Bu hedefle çalışmada, okul yöneticilerinin kriz yönetim becerilerinin belirlenmesi amaçlanmıştır. İlişkisel
tarama modellerinden, karşılaştırma türü kullanılan çalışmanın örneklemini 2021-2022 öğretim yılında KKTC’de bulunan Okul Öncesi Eğitim Kurumlarında görev yapan 576 öğretmeni ve 112 yönetici oluşturmaktadır. Araştırma sonuçlarına
göre; okul yöneticilerinin kriz yönetimi becerileri düzeyi, kendi görüşlerine göre ortalamanın üstünde, öğretmen görüşlerine göre ise ortalamada olduğu tespit edilmiştir. Öğretmen ve okul yönetici görüşleri karşılaştırıldığında,
kriz öncesi ve kriz sonrası dönem için yöneticilerin lehinde fark bulunmuştur. Okul yöneticilerin kriz yönetimi becerileri bazı değişkenlere göre farklılaşmaktadır.
Investigation of Social Studies Teachers' Attitudes and Self-Efficacy Towards Inclusive Education and Their Perceptions Of Classroom Practices by Comparison With Various Variables
Authors: ŞİMŞEK Ünal , KILCAN Bahadır
Published: August 2023

The partial existence of the studies based on the inclusion of students in inclusive education shadows the fact that teachers' roles in inclusion education. In the literature, the lack of inclusion training studies for teachers is
an indication of this situation. In the present study, which approaches inclusive education from the perspectives of teachers, it is aimed to comparatively examine teachers', who are of great importance in achieving the objectives
of inclusive education, attitudes and self-efficacy towards the inclusive education and their perceptions of inclusive classroom practices in terms of various variables. The study is a quantitative research and designed with the
relational scanning model. Predictive correlational research and casual comparison design, which are among the types of correlational research were used in the study. The implementation phase of the study was carried out with a
total of 284 social studies teachers, 122 female and 162 males, working in public secondary schools affiliated to the Ministry of Education in the central districts of Ankara and Aksaray provinces in (Turkey). In the analysis phase,
the analysis process of the study was completed by performing t-test, anova, analyses according to the status of variables included in the sub-problems. Looking at the results of the research in general; social studies teachers'
attitudes towards inclusive education, their self-efficacy and their perception of classroom practices were found to be high and positive.
Evaluación de las competencias docentes y diseño curricular para enseñar de forma remota pandemia COVID-19
Authors: Mora de la Fuente Alberto Andrés , Puc Hernández Felipe Ángeles
Published: August 2023

En la presente investigación se diseña y aplica una evaluación a las competencias que poseen los docentes para enseñar de forma online y presencial simultáneamente. Se aplica a una población de 148 docentes de enseñanza básica, de colegios particulares subvencionados de la ciudad de Antofagasta Chile, en un contexto que la educación local y mundial, acostumbrada a enseñar de forma presencial, se ve obligada a innovar nuevas modalidadzes de aprendizajes a causa de la pandemia COVID-19. El estudio fue desarrollado bajo una investigación desde el enfoque mixto, de carácter descriptivo. Se aplicaron un cuestionario bajo la escala tipo Likert de 24 preguntas validadas por juicio de expertos y dos grupos focales de ocho participantes cada uno. En la triangulación de los datos analizados se logró ratificar  las hipótesis iniciales  y validar la importancia de la evaluación docente para el proceso de mejora educativa, permitiendo conocer las necesidades de perfeccionamiento que requieren los profesionales en su formación inicial en este tipo de enseñanza y  por otro lado, que en el escenario actual no existe la necesidad  de implementar un diseño curricular para enseñar de forma remota, por variadas limitantes como son la infraestructura, medios tecnológicos y capacitación del personal.
Analisis kelayakan sumberdaya batuan sebagai peluang investasi stone crusher di dataran rendah Prafi
Authors:   Teknik Perminyakan, Fakultas Teknik Pertambangan dan Perminyakan, Universitas Papua, Kusumo Pribowo Angling , Mamengko David Victor ,   Universitas Papua
Published: August 2023

The Prafi/Arfak Lowland has potential rock resources to increase its local government revenue. Stone crusher is used by small-medium scale mining industry that supply raw materials of sands and rocks for infrastructure and road construction in Manokwari Region of West Papua. The method used consists of primary and secondary data collection as well as quantitative data analysis. This analysis aims to assess the feasibility of company’s stone crusher investment. Three main parameters were used in the assessment of investment feasibility, namely NPV (Net Present Value), DPP (Discounted Payback Period), and IRR (Internal Rate of Return). The analysis results reveal Net Present Value (NPV) of Rp. 57.068.789.003,49; Discounted Payback Period (DPP) for 2 (two) years and 11 (eleven) months and the Internal Rate of Return (IRR) of 40.22%. Based on the results of the three-parameter analysis, it can be stated that the investment made by the stone crusher company is considered feasible to run.
Gastrulation: The mechanism of the spiritual living body
Authors: Abdelrazak Mansour Ali  , Ahmed Abdelrazak Ali
Published: August 2023

This novel study would describe a new notion about the spirit, whose eternity should anticipate that it couldn’t be incorporated into our cells, rather a particular cell gene would develop during the embryonic period which could receive and decode the higher informational learning knowledge of the Spiritual energy. Gastrulation is a key developmental process during which embryonic pluripotent stem cells of the blastula reorganize into lineage-committed precursor cells to form the gastrula. Gastrulation takes place after cleavage and the formation of the blastula. The inner cell mass of embryo is pluripotent during this stage, meaning that each cell has the potential to differentiate into any cell type in the human body (organogenesis). When individual organs develop within the newly formed germ layers, then each layer gives rise to specific tissues and organs in the developing embryo. The nodal signaling pathway has a significant role in regional and cellular differentiation during development. The nodal family of proteins, a subset of the transforming growth factor beta (TGFβ) superfamily is responsible for patterning of the nervous system, It is evident that the embryo is formed in the third week post-fertilization and is accompanied by the process of brain formation that requires regulatory signals for the cells by a variety of genes that work like a communication network, during which the pluripotent embryonic stem cells and the signal induction of the homeobox genes are reorganized to plan the development and the future of embryo. Organizational plan does not take place unless a maximum information momentum is available with the highest concentration of information energy. This is the right time to blow the spirit to supply informational energy. Spirit is the eternal energy of universal cosmic information that formulate the higher cognition and consciousness of the human being, specifically, Adam’s sons.
Knowledge management practices and family businesses continuity in Edo State
Authors: Donald Ozemenbhoya EWANLEN  , Justin Mgbechi Odinioha GABRIEL
Published: August 2023

This study investigated the role of knowledge management practices in mitigating family businesses failures. The specific objectives of the study are to investigate the effect of knowledge creation, knowledge sharing and knowledge storage on the continuity of family businesses. This research adopts survey method as its research design. The population of study are the entire family businesses in Edo state. However, the accessible population are 750 of family businesses established within the periods of 1980-2020 in Edo Central and Edo North senatorial districts. Seven hundred and fifty copies of questionnaire were administered to respondents from a sample size of 150 firms mathematically determined. With the aid of STATA software, the formulated hypotheses were validated using Pearson Correlation coefficient, the Ordinary Least Square Regression method at 5% level of significance. The study found that knowledge creation and knowledge sharing exhibit positive significant relationships with family businesses’ continuity while knowledge storage report a positive and insignificant relationship with the continuity of family businesses. This paper recommend among others that founders/owners should hire high caliber employees and embrace mentoring principles in its staff development.
A Mullerian cyst simulating a cystocele
Authors: Fouad Ech chouyekh  , Sofia Jayi  , FZ Fdili Alaoui  , Hikmat Chaara  , M.A Melhouf
Published: August 2023

The differentiation of the genital tract and the urogenital sinus is made from, in the embryological stage, 2 types of canals: Wolf's canal which intervenes in male differentiation and Muller's canal origin of female differentiation, in the event of incomplete involution of residues of these canals, they can give in adulthood urogenital cysts responsible for the signs especially if there is a mass effect on the adjacent anatomical structures. We present a case of a Mullerian cyst, referred as a cystocele: 32-year-old patient admitted for management of an intravaginal mass evolving for 11 years, responsible for pelvic heaviness making sexual intercourse very painful, in whom the examination found a lump next to the anterior vaginal wall, very painful on palpation without any other associated sign, benefited from surgical excision, the anapath of which returned in favor of a Mullerian cyst. Involution of Wolf's ducts giving cysts called Gartner's cysts and involution of Muller's ducts giving cysts called Muller's cysts. Abstention is required when they are asymptomatic, otherwise the treatment is less invasive surgery.
Determining the optimum voluntary waiting period and synchronization protocol in Simmental cows
Authors: KARA Uğur , DÜZER Mehmet , HIZLI Hatice , BAKİ ACAR Duygu
Published: August 2023

The objective of the present study was to compare four different synchronization protocols at the end of various voluntary waiting period (VWP) and evaluate the effect of parity and milk yield on pregnancy rates with synchronization in Simmental cows. All animals were randomly allocated into four synchronization groups and one control group. Parity, milk yield (≤23 kg/d; >23 kg/d), and days in milk (DIM; 45-60, 61-90, >90 days) were compared according to synchronization protocols. Ovsynch (Group I; n=81), Ovsynch+Progesterone (Group II; n=30), G6G (Group III; n=66), 2xG6G (Group IV; n=45), and a control group (n=35) were designed for the study. The parity significantly affected the pregnancy rates in the primiparous cows, especially in Group II (P0.05). There was no significant difference between milk yield and pregnancy rates (P>0.05). In conclusion, the synchronization of Simmental cows with Ovsynch, Ovsynch+Progesterone, G6G, or 2xG6G did not affect pregnancy rates across various DIM. These data suggest that the suitable VWP could be planned according to the farm’s economic and local market targets, with veterinarians able to choose a protocol based on practicality, effectiveness and cost, as well as the specific requirements of the herd.
Risk Assessment of Liquid Ammonia Loading Process at Petrochemical Company Docks
Authors: Nindio Mahendra  , Hilda Gloria Natalia Tanggu Hunga  , Putri Dyah Setyorini  , Dhimas Widhi H  , A.A.B. Dinariyana Dwi P.
Published: August 2023

This study addresses a risk assessment at terminal facility of petrochemical company. Hazards are identified using HAZOP (hazard and operability) while the frequency of hazard is conducted by means of fault tree and event tree analysis. The consequence of hazards is analyzed using process hazard analysis tools and risk is represented in F-N curve according to Hongkong Government Risk Guidelines (HKRG). Five leak diameter scenarios were examined resulting that two hazards are potentially occur during the ammonia loading process such as gas dispersion and explosion. According to the result of frequency and consequence analysis, those hazards is laid in ALARP (as low as reasonably practicable) region, hence there is no mitigation necessarily to be taken. However, for the safe operation, the company should ensure that the risks will not move to unacceptable region by performing routine maintenance and all safety procedures established by the company were well implemented.
The Effect Of Retained Earnings On Trading Volume Activity (TVA) With Return On Assets As A Moderation Variable
Authors: Prima Sari Pristin , Prima Putra Ardian , Rinofah Risal
Published: August 2023

Trading Volume Activity (TVA) indicates the amount of stock trading volume in a company's stock market. Companies with good stock volume and financial performance can increase stock trading volume. The research aims to empirically examine the effect of retained earnings on Trading Volume Activity (TVA) with Return On Assets (ROA) as a moderating variable. The study uses data from the 2018-2020 financial statements of companies in the consumption and construction services sector listed on IDX and analyzed using moderation regression analysis. The results show that the variable retained earnings is simultaneously significant to Trading Volume Activity (TVA) with Return On Assets (ROA) as a moderating variable. Partially retained earnings can significantly influence Trading Volume Activity (TVA), while ROA can moderate the retained earnings variable on Trading Volume Activity (TVA). The research contributes that companies can increase the amount of retained earnings and increase ROA so that trading volume can be increased. The more companies trade, the value-added received will increase
Greenery as a mitigation strategy to urban heat and air pollution: a comparative simulation-based study in a densely built environment
Authors: Salvalai Graziano , Blanco Cadena Juan Diego , Quagliarini Enrico
Published: August 2023

The urban heat island and the urban air pollution concentration are two major climate-change-related phenomena affecting the built environment worldwide. This paper aims to verify the potential effect of different mitigation measures through a simulation study. In detail the present study focuses on the analysis of the environmental impacts of urban vegetation, such as green facades, vertical greenery, and green pavements. After an extensive screening of the literature review, an investigation of the impact of the most common built environment design variables in a defined case study led to the definition of a typical urban canyon was tested. The results show that the presence of trees in a street canyon could reduce the air temperature peaks by 5-10 °C, while the high-level vegetation canopies can lead to a deterioration in air quality with a PM concentration increasing by 1.2-1.5%. Instead, using low-level green infrastructure improves the air quality conditions on the sidewalk, reducing the NOx in the range of 10-20%. The analyzed high-level greenery generated an air temperature reduction effect on a street level ranging from 8 to 12°C. The present work contributes to clarifying the potential mitigation effect of green infrastructure in a densely built environment, where the risk of increasing temperatures and air pollutants is foreseen to be more intense in the coming years.
Relationship Between Social Withdrawal (Hikikomori), Personality, and Coping in an Adult Population
Authors: Bonnaire Céline , Roignot Zoé
Published: August 2023

Objective The aim of this study was to investigate the relationships between personality dimensions, coping strategies, and Hikikomori while controlling for the presence of depression and anxiety.Methods Two groups, recruited on social networks, were compared: the control group (n=101, mean age±standard deviation [SD]= 36.2±12.8 years) and the Hikikomori group (n=28, mean age±SD=30.1±9.1 years). Participants of both groups completed the Big Five Inventory, the Brief Coping Orientation to Problems Experienced, and the Hospital Anxiety and Depression Scale.Results The Hikikomori group had higher depression, anxiety, neuroticism, and dysfunctional coping dimension (self-blame and behavioral disengagement) scores than the control group. Being alone and depression were positively associated with Hikikomori while extraversion and instrumental support were negatively associated with Hikikomori.Conclusion These findings contribute to a better understanding of the psychological functioning of Hikikomori as well as to treatment elaboration and confirm that some psychological characteristics are transcultural.
Polymorphism of Estrogen Receptor Genes and Its Interactions With Neurodevelopmental Genes in Attention Deficit Hyperactivity Disorder Among Chinese Han Descent
Authors: Lin Yiwei , Li Haimei , Zhang Jing , Yang Ziqi , Zhou Yi , Liu Lu , Qian Qiujin
Published: August 2023

Objective Attention deficit hyperactivity disorder (ADHD) is a polygenic neurodevelopmental disorder with significant gender differences. The sexual dimorphism of ADHD may be associated with estrogen acting through estrogen receptors (ESR). This study investigates the impact of ESR gene polymorphism and its interactions with neurodevelopmental genes on ADHD susceptibility.Methods The study compared genotyping data of single nucleotide polymorphisms in ESR1 and ESR2 in 1,035 ADHD cases and 962 controls. The gene-gene interactions between ESR genes and three neurodevelopmental genes (brain-derived neurotrophic factor [BDNF], synaptosomal-associated protein of 25 kDa gene [SNAP25], and cadherin-13 [CDH13]) in ADHD were investigated using generalized multifactor dimensionality reduction and verified by logistic regression analysis.Results The G allele of rs960070/ESR2 (empirical p=0.0076) and the A allele of rs8017441/ESR2 (empirical p=0.0426) were found significantly higher in ADHD cases than in the controls but not in male or female subgroups. Though no difference was found in all subjects or females, the A allele of rs9340817/ESR1 (empirical p=0.0344) was found significantly higher in ADHD cases than controls in males. We also found genetic interaction models between ESR2 gene, neurodevelopmental genes and ADHD susceptibility in males (ESR2 rs960070/BDNF rs6265/BDNF rs2049046/SNAP25 rs362987/CDH13 rs6565113) and females (ESR2 rs960070/BDNF rs6265/BDNF rs2049046) separately, though it was negative in overall subjects.Conclusion The ESR gene polymorphism associates with ADHD among Chinese Han children, with interactions between ESR genes and neurodevelopmental genes potentially influencing the susceptibility of ADHD.
Penerapan Algoritma Finite State Machine Pada Game “Knight And King” Dengan Metode Game Development Life Cycle
Authors: Kristian Eri , Mastan Ignatius Adrian
Published: August 2023

Salah satu jenis permainan yang digemari yaitu platformer 2D. Jenis permainan ini semakin popular saat ini, karena kepopuleran permainan mobile dan platformer yang muncul di mobile. Penelitian ini berupa perancangan permainan mobile platformer 2D dengan menerapkan algoritma finite State machine untuk memberi kepintaran terhadap musuh, dan metode gamedevelopment life cycle sebagai metode perancangan permainan agar game menjadi lebih menarik dan interaktif. Penelitian ini dilakukan dengan kuesioner dan pengembangan prototype. Hasil penelitian ini adalah dapat membuat permainan mobile dengan algoritma finite Statemachine dan metode game development life cycle.
Выбор адаптивного дизайна в исследованиях биоэквивалентности. критерии принятия решений
Authors: Еременко Наталья Николаевна , Горячев Д. В.
Published: August 2023

Выбор адаптивного дизайна в исследованиях биоэквивалентности возможен для лекарственных средств, для которых отсутствуют данные о вариабельности фармакокинетических параметров (коэффициент внутрииндивидуальной вариабельности CVintra). Это дизайн с проспективным планированием модификации размера выборки добровольцев на основе анализа результатов, полученных в данном исследовании. Цель работы — анализ руководящих документов и протоколов исследований биоэквивалентности с адаптивным дизайном на предмет обоснованности выбора данного дизайна по ряду параметров. По результатам проведенного ретроспективного исследования обозначены ключевые моменты, выявлен перечень недостатков. Отмечена необходимость проведения всестороннего литературного поиска значений CVintra, при отсутствии которых и/или наличии противоречивых данных выбор адаптивного дизайна будет обоснованным. Представлены критерии принятия решений для выбора адаптивного дизайна в исследованиях биоэквивалентности. Представленные примеры позволят унифицировать подход и избежать ошибок в планировании дальнейших исследований биоэквивалентности.
Эндотелиопротективное действие ГАМК и нового производного ГАМК – композиции МФБА у животных после длительной диабетической гипергликемии
Authors: Тюренков Иван Николаевич , Бакулин Дмитрий Александрович , Борисов Александр Владимирович , Абросимова Елизавета Евгеньевна , Верхоляк Дмитрий Викторович , Васильева Ольга Сергеевна
Published: August 2023

Целью исследования являлось изучение эндотелиопротективного действия ГАМК и ее нового производного — композиции МФБА, состоящей из гидрохлорида метил-4-амино-3-фенилбутаноата и гидрохлорида L-аргинина в соотношении 1:1, в условиях длительной гипергликемии. В качестве модели использовали крыс Вистар (12 мес) с 6-месячным стрептозотоцин-никотинамид-индуцированным сахарным диабетом. Проводили глюкозотолерантный тест и распределяли животных на группы, которым в течение 4 недель внутрь вводили ГАМК и композицию МФБА. Далее оценивали уровень гликемии, суточную протеинурию, функциональное состояние эндотелия: его вазодилатирующую, антитромботическую функцию, уровень фактора фон Виллибранда (vWF) и количество циркулирующих эндотелиальных клеток в крови. Методом ИФА в плазме крови определяли содержание ряда маркеров, в большей степени влияющих на развитие осложнений сахарного диабета (белок Клото, BDNF, Nrf2, ФНО-α и iNOS). Показано, что длительная гипергликемия приводила к формированию эндотелиальной дисфункции, которая проявлялась снижением эндотелийзависимой вазодилатации и антитромботической функции эндотелия, увеличением в крови циркулирующих эндотелиальных клеток и уровня vWF, а также суточной протеинурии. В плазме наблюдалось снижение содержания белка Клото, BDNF, Nrf2 и повышение содержания провоспалительных факторов ФНО-α и iNOS. Курсовое введение ГАМК и МФБА приводило к снижению гликемии и значительному улучшению вазодилатирующей и антитромботической функции эндотелия, повышению плазменного уровня белка Клото, нейротрофического фактора BDNF и транскрипционного фактора Nrf2, а также снижению ФНО-α и iNOS. По сравнению с ГАМК ее производное — композиция МФБА оказывала более выраженное действие в меньшей дозе (20 мг/кг в сравнении с 1000 мг/кг). Таким образом, производное ГАМК — композиция МФБА при длительной гипергликемии, помимо гипогликемического, оказывает выраженное эндотелиопротективное действие, улучшая вазодилатирующую и антитромботическую функции эндотелия и снижая содержание провоспалительных факторов ФНОα, iNOS и количество циркулирующих эндотелиальных клеток, что указывает на ее возможный высокий потенциал в качестве средства для профилактики сосудистых осложнений сахарного диабета.
Pioneering anther culture-based embryogenesis in Solanum aethiopicum L.
Authors: SHİMİRA Flavien , KARA Ecem , TAŞKIN Hatıra
Published: August 2023

This study aimed to establish a compelling approach for inducing embryogenesis through in vitro anther culture in Scarlet eggplant (Solanum aethiopicum L.), the most consumed and popular eggplant among indigenous vegetables on the African continent. While in vitro androgenesis has been favorably employed in brinjal (Solanum melongena L.) breeding, there has been no attempt to induce embryogenesis in a large germplasm of its relative, Solanum aethiopicum. In two distinct experiments, the largest germplasm collection of Solanum aethiopicum gr. Gilo was assessed for embryogenesis induction using C medium supplemented with different concentrations of hormones. In the first experiment, callus induction was successful with an overall rate of 36.6 calli/100 anthers, but embryo formation was unsuccessful. Statistical analysis revealed a dependency of the rate of callus induction on accessions. In the second experiment, only four selected accessions of Solanum aethiopicum gr. Gilo were used and compared to two Turkish eggplant genotypes of Solanum melongena in two distinct treatments. The results showed that in the first treatment (I), only the accession GKE12 had a satisfactory outcome with a rate of embryo formation of 0.82/100 anthers and 0.41/100 anthers corresponding to the rate of developed embryos. In the second treatment (II), only controls, which were Adana and Kemer cultivars of Solanum melongena formed embryos with a rate of 7.26/100 anthers and 1.15/100 anthers, respectively. The obtained embryo/seedling of Solanum aethiopicum gr. Gilo was found to be diploid. Overall, this study demonstrated that with the right combinations of hormones, it is possible to induce embryogenesis and produce a diploid of Solanum aethiopicum, the world’s second most popular cultivated eggplant after brinjal. These findings could potentially contribute to the breeding of eggplants for enhanced genetic variation and resistance.
Constructing an Educational “Quality” Crisis: (E)quality Politics and Racialization Beyond Target Beneficiaries
Authors: McCambly Heather , Mulroy Quinn
Published: August 2023

In this critical, political discourse analysis, we trace how two concepts, equity and quality, became discursively linked and contested in the administration of postsecondary education policy over time (1968–1994)—a developmental process we refer to as (e)quality politics. By engaging in a historical analysis, we investigate (a) the racialized political origins and discursive processes by which arguments over educational “quality” are advanced as part of an antiequity policy paradigm and (b) how this paradigm reinscribes racial inequity into administrative and organizational action over time. We illustrate how, once an (e)quality politics paradigm is established, racialized policy designs can persist, even in the absence of explicit references to racialized social constructions of target populations in later periods of policy development.
European experience in preventing and combating crime by customs authorities and the possibility of its use in Ukraine
Authors: Volodymyrovych Nosach Andrii , Ihorevych Fialka Mykhailo , Anatolevich Cherkasskyi Ruslan , Svitlana Volodymyrivna Selezen
Published: August 2023

Nowadays, quite effective systems have been formed in the world to combat and prevent customs crimes in general and by customs authorities, however, the experience of not all states is positive. The article, based on the analysis of the scientific views of scholars, summarizes the experience of the leading European countries (on the example of Great Britain, France, Germany) in the field of preventing and combating crime by customs authorities. Both positive and negative aspects of the experience in the field of combating crime in these countries are singled out. The analysis of foreign experience in preventing and combating crime by customs authorities made it possible to formulate the following points that should be used by the domestic legislator: firstly, a high level of material, technical and financial support of the customs authorities, which makes it possible to more quickly respond to existing challenges; secondly, the customs authorities of the vast majority of countries have a wide range of powers in the context of the implementation of intelligence operations; thirdly, a high level of interaction and exchange of information between the EU countries in the framework of combating customs crime; fourthly, an important aspect of combating and preventing customs crime is the professional training of customs personnel; fifthly, on the example of foreign countries in Ukraine, it was expedient to strengthen administrative and criminal liability for violation of customs legislation; sixth, a high level of social and financial support for customs employees.
Đôi câu hỏi xoay quanh hiểu biết về tổn thất sinh thái trong tương quan với hoạt động kinh tế-xã hội của con người
Authors: Chàng Chẫu
Published: August 2023

Rất mong ngày nào đó lại được đọc bài về những đáp án cho đôi câu hỏi vừa mới nêu trên.
UPAYA MENINGKATKAN HASIL BELAJAR SISWA MATERI DUA KALIMAT SYAHADAT DENGAN METODE CARD SHOT PADA SISWA KELAS 1 MI MAMBAUL HIKAM PESANTREN ULUJAMI PEMALANG
Authors: Ulfah Siti Mariyah
Published: August 2023

Siswa kelas 1 MI Mambaul Hikam Pesantren mengalami penurunan belajar pada tahun sebelumnya, dari 26 yang tuntas 39% dan yang belum tuntas 61%.pada tahun ini 2021/2022 target yang ingin dicapai dari 20 siswa adalah 85% tuntas dengan rata rata nilai 80. Tujuan penelitian adalah untuk meningkat hasil belajar siswa dan juga motivasi belajar siswa dalam pembelajaran Akidah Akhlak materi dua kalimat syahadat.Penelitian ini merupakan penelitian tindakan kelas dengan menggunakan metode card sort, sumber data penelitian ini adalah siswa kelas 1 MI Mambaul Hikam Pesantren adapun teknik pengumpulan data dilakukan dengan melalui tes pemahaman materi dan obsevasi.Hasil penelitian pada siklus I menunjukkan siswa yang menguasai materi mencapai 60% dan siswa yang tidak menguasai materi mencapai 40% dengan rata rata kelas mencapai 71 .pada siklus II mengalami peningkatan hasil belajar menjadi 86% yang menguasai materi dan 14% yang tidak menguasai materi dengan rata-rata 80
Efficient presentations for two simple groups
Authors: Kenne P E
Published: August 2023

Efficient presentations are given for the alternating group of degree 12 and the third Janko group. This extends the list of finite simple groups known to have efficient presentations.
Intervenciones farmacológicas tempranas para la prevención universal del trastorno de estrés postraumático (TEPT)
Authors: Beltrán Gabriela Ponce , Cortes-Jofre Marcela , Ortiz-Muñoz Luis E.
Published: August 2023

El trastorno de estrés postraumático (TEPT) es una afección de salud mental que algunas personas desarrollan tras experimentar algún evento traumático. Ya que realizar prevención primaria es difícil, los enfoques se centran en encontrar tratamientos que administrados lo más cercano al evento puedan generar una prevención secundaria.
Artroplastías para las fracturas de cadera en adultos
Authors: Ibáñez Diego Garrido , Alvarado Chavez Mariana , Cortes-Jofre Marcela , Ortiz-Muñoz Luis E.
Published: August 2023

Una fractura de cadera o fractura de fémur proximal consiste en una ruptura ósea en la región superior del fémur, entre la región subcapital (el área justo debajo de la cabeza femoral) y 5 cm por debajo del trocánter menor. Cuenta con distintas opciones de tratamiento, la gran mayoría quirúrgicas, y dentro de las cuales destaca la artroplastía como una alternativa eficaz para resolver dicha patología.La artroplastía de cadera consiste en una técnica quirúrgica que reemplaza parte (hemiartroplastía) o la totalidad de la articulación de la cadera (artroplastía total) con una endoprótesis: un implante construido con materiales no biológicos como metal, cerámica o polietileno. La fijación de dicho constructo protésico al hueso coxal y femoral puede ejecutarse con técnica cementada o no cementada, según la preferencia y curva de aprendizaje del cirujano.
Signed and Unsigned Effects of Prediction Error on Memory: Is it a Matter of Choice?
Authors: Pupillo Francesco , Bruckner Rasmus
Published: August 2023

Adaptive decision-making is governed by at least two types of memory processes. On the one hand, learned predictions through integrating multiple experiences, and on theother hand, one-shot episodic memories. These two processes interact, and predictions – particularly prediction errors – influence how episodic memories are encoded.However, studies using computational models disagree on the exact shape of this relationship, with some findings showing an effect of signed prediction errors and othersshowing an effect of unsigned prediction errors on episodic memory. We argue that the choice-confirmation bias, which reflects stronger learning from choice-confirming compared to disconfirming outcomes, could explain these seemingly diverging results. Our perspective implies that the influence of prediction errors on episodic encoding critically depends on whether people can freely choose between options (i.e., instrumental learning tasks) or not (Pavlovian learning tasks). The choice-confirmation bias on memory encoding might have evolved to prioritize memory representations that optimize reward-guided decision-making. We conclude by discussing open issues and implications for future studies.
Crop Height Estimation with LiDAR Equipped Robots
Authors: Xu Tianshu
Published: August 2023

Estimating the height of crops is important from anenvironmental and economic point of view. For example,accurate and timely estimates of plant growth can be oftremendous help for high-throughput phenotyping [1]. Thisdata can be used for determining the genetic variety that isable to better withstand nutrient stress, diseases, and pests [1].However, manually measuring crop height can be a tediousprocess, especially as the plot size increases. As opposed tomeasuring a selected few crops and extrapolating informationto the entire plot, more accurate information can be gathereddue to the robots collecting a higher amount of samples anddata. We are developing a robotic system for measuring cropheight, among other phenotype data, to facilitatehigh-throughput phenotyping. In this paper, we report ourprogress on crop height estimation using both ground andaerial robots.
Binge eating disorder and food addiction occurrences among adult Jordanian women with obesity
Authors:   Department of Nutrition and Food Technology, Faculty of Agriculture, the University of Jordan, Amman, Jordan., Zueter Zainab , Mashal Rima Hussein ,   Department of Nutrition and Food Technology, Faculty of Agriculture, the University of Jordan, Amman, Jordan.
Published: August 2023

Introduction: The aim of the study was to estimate the occurrences of binge eating disorder (BED) and food addiction (FA) in Jordanian women with obesity and to explore their relationships with selected potential risk factors for obesity. Methods: A descriptive case series design that involved a total of 842 women with obesity was conducted. The occurrences of BED and FA were evaluated using the Questionnaire on Eating and Weight Patterns-5 (QEWP-5) and Yale Food Addiction Scale 2.0 (YFAS 2.0). Results: The overlapping of BED and FA (BED+FA) was the most frequent category constituting 53.7%. The second highest category was BED comprising 25.0%, followed by FA comprising 9.0%. Body mass index (BMI) and waist circumference (WC) were significantly higher in the BED+FA group as compared to all other groups. The FA group (41.3%) had significantly the lowest level of sleeping hours. BED (58.0%) and BED+FA (66.1%) groups were significantly higher in consuming more than three snacks per day. BED and/or FA-free group had significantly higher level of water intake of >5 cups/day. Conclusions: The frequencies of BED and FA were relatively high among obese Jordanian women. The study demonstrated an overlap between BED and FA, highlighting its associations with increased BMI and WC in a selected sample of obese women. The study suggested that BED, FA, and the overlapping of both conditions were associated with greater tendencies towards an unhealthy pattern of eating practices, fluid intake, and sleeping habits.