bluuebunny/crossref_metadata_2025 huggingface dataset:
Ameliorative effect of Brassinosteroids and Biochar on Morpho-physiological Attributes of Tomato (Lycopersicon esculentum Mill.) Under Induced Drought Stress
Authors: Zada Jehan , Hazrat Ali , Ullah Sami , Nafees Muhammad
Published: January 2024

Plant growth and development are impeded by abiotic stresses that interfere with physiological processes. This study aimed to assess the distinct and combined effects of biochar and brassinosteroids (BRs) on Rio Grande and Amitabh-004 tomato plants under water deficit stress. Results showed that biochar has porous morphology with significant water absorption and retention capability as inveterate by SEM. EDX of biochar illustrated the existence of various essential elements including carbon (75.04%), oxygen (13.57%), nitrogen (5.66%), potassium (2.43%), and calcium (1.52%). Similarly, Co-application of biochar and BRs quenched the drought stress by triggering antioxidant-enzymes including POD, APX, CAT and SOD accompanied with photosynthetic pigments boosting and amplification of osmolytes including proline, sugar and proteins for the better survival of plants under stress. Furthermore, HPLC of Gallic acid was identified at the retention time of 2.307 with peak area 63.25 and Vitamin-C at 3.15 retention times with peak area of 34.27 in all treatments of both varieties supplemented with different stresses along with biochar and BRs. Furthermore, Drought-stress significantly affects the agronomic feature of tomato plants such as leaf area, fresh biomasses of leaf, root and shoot, root length. Physicochemical characteristics i.e., pH, soil moisture, and percent field capacity are also adversely affected by water deficit stress. The principal component of physiological attributes was found to have 20.51% followed by 17.93%, 14.70%, 11.68% and 10.69%. Conclusively, the study emphasizes the potential of biochar and BRs to alleviate drought stress and enhance physio-biochemical attributes, thereby promoting improved plant growth under water deficit conditions.
Role of LsrR in the regulation of biofilm formation in mammary pathogenic Escherichia coli
Authors: Xu Li , Wang Wei , Zhang Xin , Ma Kai , Wang Hui , Xue Ting
Published: January 2024

Background
Mammary Pathogenic Escherichia coli (MPEC) is an important pathogen that can escape the attack of the host immune system through biofilm formation and proliferate in the mammary gland continuously, resulting in mastitis in cows and causing enormous economic losses. As an effector of AI-2 quorum sensing, LsrR extensively affects the expression levels of hundreds of genes related to multiple biological processes in model E. coli strain. However, the regulatory role of LsrR in MPEC and whether it is involved in pathogenesis has been seldom reported.
Results
In this study, the function of LsrR in strain MPEC5, obtained from a milk sample in dairy cows with mastitis, was investigated by performing high-throughput sequencing (RNA-seq) assays. The results revealed that LsrR down-regulated the transcript levels of fimAICDFGH (encoding Type 1 pili), which have been reported to be associated with biofilm formation process. Biofilm assays confirmed that deletion of lsrR resulted in a significant increase in biofilm formation in vitro. In addition, electrophoretic mobility shift assay (EMSA) provided evidence that LsrR protein could directly bind to the promoter regions of fimAICDFGH in a dose-dependent manner.
Conclusions
These results indicate that LsrR protein inhibits the biofilm formation ability of MPEC5 by directly binding to the fimAICDFGH promoter region. This study presents a novel clue for further exploration of the prevention and treatment of MPEC.
Effects of short-time fasting and feeding frequencies within 24 hours on histology, cholecystokinin and trypsin enzyme activities of digestive organs in black bream, Megalobrama pellegrini (Tchang, 1930), juvenile
Authors: Li Wenyu , Tang Hongyu , Lin Xiaogang , Ma Feifan , Zhang Kaicheng , Zhang Wenqi , Li Qin
Published: January 2024

To study the regulation and feedback mechanism of cholecystokinin and trypsin in black bream, Megalobrama pellegrini (Tchang, 1930) 60 days after hatching under 15 days short-term fasting and different feeding frequencies within 24 hours during the same period, M. pellegrini (wet weight 183.75 ± 61.16 mg, total length 20.74 ± 4.08 mm) developed in a recirculating aquaculture system were selected as the subject. In the short-term fasting trial, the body weight, trypsin, and CCK of the feeding control group (FCG) were higher than those of the fasting test group (FTG). Trypsin and CCK in FTG reached the lowest value on the ninth day and the CCK content reached the highest value on the 11th day. A negative feedback regulation of CCK and trypsin had not been found in this trial. The degree of damage to intestinal chorionic epithelial cells was higher than that of hepatopancreas, and detachment of epithelial cells and the striatal border was the main damage. In the 24-hour daily rhythm experiment, juvenile fish were randomly assigned to (A) once feeding, (B) twice feeding, (C) three times feeding, (D) fasting. CCK showed a minimum value at 1:00+ in group A, while a peak occurred at night in group B\C\D and a maximum value in group C, and a single satiety stimulus can lead to increased hunger. The four treatment groups had an apparent closed-loop regulation while the control point of the fasting group (D) shifted forward to the next day. Different feeding frequencies in a single day had no direct effect on the long-term fluctuation of CCK and trypsin diurnal rhythm. Feeding three times a day was beneficial to the individual growth of juvenile M. pellegrini, a better growth results may be produced in the long term. This study aimed to provide a reference for the feeding strategy of juvenile M. pellegrini in the RAS.
Influence of astigmatic aberration on partially coherent Gaussian-Schell vortex beam focused by lensacon
Authors: Alkelly Abdu , Al-Nadary Hatim , Kaid Shukri , Ahsab Hassan Al-
Published: January 2024

We investigated the propagation properties of a partially coherent GaussianSchell model vortex (PCGSMV) beam in an astigmatically aberrated lensacon optical sys-tem. By applying the extended Huygens-Fresnel principle, we developed a cross-spectraldensity expression for PCGSMV beams passing through a lensacon with aberrant astigma-tism. Our numerical results demonstrated that astigmatic aberration significantl yinfluencesthe intensity distribution and depth of focus. Moreover, our study illustrates the impact ofthe spectral degree of coherence, propagation distance, axicon base angle, and astigmaticaberration coefficien to nth evorte xprofil e.O urresul tsreveal edtha t, atf ardistance s,awide-diameter dark spot size with oscillation was generated. These finding sar esignificantfor applications such as sensor technology, optical trapping, and micro-particle manipulation.
Alcohol use disorder in patients after undergoing bariatric surgery
Authors: Oliveira Kátia Cristina , Santa-Cruz Fernando , Leão Luciana M. Souza , Kreimer Flávio , Ferraz Álvaro A. B.
Published: January 2024

Purpose: to evaluate the impact of bariatric surgery on the incidence of Alcohol Use Disorder (AUD) and depression during the postoperative period.
Methods: A prospective study was conducted, evaluating 68 patients who underwent either sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB). The presence of AUD and depression was assessed both pre- and postoperatively. AUD assessment utilized the AUDIT-C score, while depression assessment employed the Beck Depression Inventory (BDI).
Results: The average age of the sample was 42.81 ± 9.28 years, with 85.3% being female. The meanfollow-up duration was 16.54 ± 7.41 months. In the preoperative assessment, 92.6% of the sample fell into the low-risk category for AUD according to the AUDIT-C. No statistically significant difference was observed between the RYGB and SG groups. Postoperatively, 89.7% of the sample was classified as low risk for AUD, with no significant differences comparedto the preoperative assessment. Regardingdepression, there was no significant difference between the pre- and postoperative periods for all patients. However, a notable trend towards a reduction in "severe depression" was observed in the postoperative period for patients undergoing SG (pre: 14.0% vs. post: 7.0%, p=0.013).
Conclusion: There is no significant difference in the presence of AUD and depression between pre- and postoperative assessments in patients who have undergone bariatric surgery.
Tributyrin displayed the potential nutrient mechanism by improving the growth of rumen bacteria of weaned lambs rather than via releasing butyric acid
Authors: Wang Yaxin , Chen Hua , An Ran , Ren Qingchang
Published: January 2024

Background
Tributyrin (TB), a feed additive, has been widely proved to display a benefit in stimulating the gastrointestinal tract development of livestock. For a long time, the benefit of TB is regarded as the prodrug of butyric acid. However, more and more studies recently showed that supplementing TB could enhance gastrointestinal microbiotas accompanied with the benefit. Here, we investigated the potential nutrient mechanism of TB based on in vitro ICE-6 intestinal epithelial cell culture in the absence of bacteria and in vivo experiment with involvement of rumen bacteria.
Results
In vitro experiment showed that butyric acid linearly increased both the late and early apoptotic ICE-6 intestinal epithelial cells, but similar effects were not observed in the same concentrations of TB. In vivo experiment showed that supplementing TB increased dry matter intake of lambs and daily retentions of dietary serine, cysteine and methionine. Besides, lambs fed TB had higher faecal excretions of C12:0, C13:0, C18:2n6c, C18:3n3 and C20:0 but lower C16:1n9c, C17:0 and C18:1n9c compared with that of lambs provided no TB. The correlation analysis showed that daily retentions of dietary serine, methionine and cysteine were positively correlated with the relative abundances of ruminal Fibrobacter, Butyrivibrio, Bifidobacterium and Firmicutes, respectively. In addition, the relative abundance of rumen Clostridium was positively correlated with the daily decreases of C6:0, C18:1n9c, C18:2n6c and the daily increases of C13:0, C15:0 and C18:0, respectively. Meanwhile, the relative abundance of rumen Fibrobacter was positively correlated with the daily decreases of C6:0, C16:0, C18:1n9c, C18:2n6c, C18:3n3, C20:0, C22:0, C24:0 while was negatively correlated with the daily increases of C14:0, C15:0, C16:1n9c and C18:0, respectively. Furthermore, the relative abundance of rumen Butyrivibrio was negatively correlated with the daily increases of C14:0, C16:1n9c, C17:0 while was positively correlated with the daily decreases of C16:0, respectively.
Conclusions
Our both in vitro and in vivo experiments revealed that supplementing TB could display the nutrient mechanism by improving the growth of rumen bacteria rather than via releasing butyric acid.
Synergistic inhibition of APE1 redox activity and ATM activation sensitizes osteosarcoma cells to ionizing radiation by inducing ferroptosis
Authors: Xiao Han-xi , Jiang Nan , Zhang Hong-bin , Wang Shuai , Pi Qin , Chen Hua-wei , He Xuan , Luo Wei , Deng Youcai , Lu Yonghui , Zhong Zhaoyang
Published: January 2024

The resistance of osteosarcoma (OS) to ionizing radiation (IR) is a great obstacle for its radiotherapy. Apurinic/apyrimidinic endonuclease-reduction/oxidation factor 1 (APE1/Ref-1) is a multifunctional protein with DNA repair and reduction/oxidation (redox) activities. Our previous study revealed a role of APE1 in OS radioresistance, but whether the redox activity of APE1 is involved is not clear. Moreover, APE1 has recently been shown to regulate ataxia-telangiectasia mutated(ATM) activation, which is an initiator of DNA damage response and mediates radioresistance in several other cancers. Although their role in radioresistance of OS remains to be studied, the possible crosstalk between APE1 redox activity and ATM activation may complicate the mechanism of OS radioresistance. Our results revealed that IR increased APE1 expression and ATM activation in OS cells, and APE1 directly regulated ATM activation by its redox activity. The synergetic administration of APE1 redox inhibitor and ATM inhibitor effectively sensitized OS cells to IR. Further study revealed that ferroptosis mediated the radiosensitization of OS cells induced by the combined inhibition of APE1 redox activity and ATM activation. Moreover, simultaneous treatment withthese two inhibitors, rather than each alone, drastically decreased the expression of their common targeting transcription factor p53. Taken together, our results demonstrated that APE1 redox activity and ATM activation as well as their crosstalk played important roles in the resistance of OS to irradiation, and synergetic inhibition of APE1 redox activity and ATM activation sensitized OS cells to IR by inducing ferroptosis, which providesa promising strategy for OS radiotherapy.
Targeting TFF3 in obstructive airway diseases: a computational approach to novel therapeutics
Authors: Shahriary Alireza , Sisakht Mohsen , Arabfard Masoud , Behmard Esmaeil , Najafi Ali
Published: January 2024

Background
Airway remodeling, a hallmark of chronic obstructive pulmonary disease (COPD) and Mustard lung disease, is influenced by the Trefoil Factor 3 (TFF3). This study sought to pinpoint a compound with minimal toxicity that can effectively suppress TFF3 expression and activity.
Methods and Results
We employed an integrative approach, combining gene expression analysis, molecular docking, and molecular dynamics simulations, to identify potential TFF3 inhibitors. The biological safety of these compounds was ascertained using a sophisticated deep neural network model. Of the compounds assessed, eight manifested a significant reduction in TFF3 expression, with binding affinities (ΔG) ranging from − 7 to -9.4 kcal/mol. Notably, Genistein emerged as the frontrunner, showcasing potent TFF3 downregulation, minimal toxicity, and a robust inhibitory profile as evidenced by molecular dynamics simulations.
Conclusion
Genistein holds promise as a therapeutic agent for TFF3-mediated conditions, including mustard lung disease. Its potential to address the current therapeutic gaps is evident, but its clinical utility necessitates further in vitro and in vivo validation.
The association between intergenerational financial support and multidimensional health poverty among Chinese older adults: analysis of data from the China Health and Retirement Longitudinal Study (CHARLS)
Authors: Cai Yue , Xue Yang , Yao Yuanyuan , Jing Zhengyue , Xue Yu
Published: January 2024

Background
Previous studies have indicated that intergenerational financial support was associated with health poverty among older adults, but few studies have accounted for multidimensional characteristics of health. This study aims to investigate the incidence of multidimensional health poverty among older adults, and explore the effect of intergenerational financial support on the multidimensional health poverty among older adults in China.
Methods
This study was based on the data from China Health and Retirement Longitudinal Study (CHARLS) 2018. A total of 3,937 adults aged 60 years and older were included in this study. Multidimensional health poverty was measured through three dimensions: physical health poverty, mental health poverty, and social health poverty, and the Alkire-Foster (AF) method was used to evaluate the incidence of multidimensional health poverty among older adults. Logistic regression models and OLS regression models were employed to explore the association between intergenerational financial support and multidimensional health poverty among older adults.
Results
The index of multidimensional health poverty among older adults was 0.365, and the incidence of multidimensional health poverty was 63.3% at the threshold of 1/3. Intergenerational financial support was associated with multidimensional health poverty among older adults (OR = 0.880, P < 0.001). Furthermore, intergenerational financial support had a negative impact on physical health poverty (Coef. = -0.002, P < 0.05), mental health poverty (Coef. = -0.008, P < 0.01), and social health poverty (Coef. = -0.009, P < 0.01), respectively.
Conclusions
This study demonstrates that the incidence of multidimensional health poverty was higher among older adults, and intergenerational financial support was negatively associated with multidimensional health poverty. Policymakers should explore home-based interventions to reduce the incidence of multidimensional health poverty among older adults.
Bridging Hearts and Nurturing Bonds: A Holistic Exploration of Postpartum Depression, Social Support, and Breastfeeding Self-Efficacy among Women in Gujarat, India
Authors: Surati Bhumika , M Yogesh , Munshi Raza , Vamja Roshni
Published: January 2024

Background
Postpartum depression and breastfeeding practices are interlinked maternal health issues requiring greater attention in India.
Objectives
This study examined associations between postpartum depression, social support, breastfeeding attitudes, and self-efficacy among postpartum women in Gujarat, India.
Materials and Methods
In this cross-sectional study, 400 postpartum women were recruited from a tertiary hospital. Depression was assessed using the Edinburgh Postnatal Depression Scale. Social support, breastfeeding attitudes, and self-efficacy were measured using validated scales. Logistic regression models were constructed to identify predictors of probable depression.
Results
The prevalence of probable postpartum depression was 28% (112/400). Lower socioeconomic status (upper lower class AOR 2.6, 95% CI 1.2–5.5) and lower social support (per 1 unit increase AOR 0.97, 95% CI 0.94–0.99) were significant independent risk factors for probable depression in multivariate modeling. There were negative correlations between depression scores and social support (r=-0.35, p < 0.001), breastfeeding attitudes (r=-0.21, p < 0.001), and self-efficacy (r=-0.42, p < 0.001). Social support and breastfeeding attitudes showed positive correlations with breastfeeding self-efficacy (r = 0.61 and r = 0.33 respectively, p < 0.001)
Conclusion
The key findings indicate lower socioeconomic status and social support as major risk factors for postpartum depression among women in Gujarat. Routine psychosocial assessment and support are recommended in postnatal care. Social support and positive attitudes may enable higher breastfeeding self-efficacy. The results highlight the need for targeted interventions to address depression and improve breastfeeding practices.
The Role of the Social Network in Adopting New Turfgrass Varieties: An Analysis of Twitter Data
Authors: Han Joohun , Chung Chanjin , Wu Yanqi
Published: January 2024

This study examines the effect of social learning on new turfgrass variety adoption decisions using data from 231 turfgrass professionals’ Twitter accounts between 1 Jun 2018 and 31 Dec 2019. To determine the social learning effect, we decompose networking effects into social learning, individual-level and group-level similarities, herd behavior, and clustering effects. Our study estimates a spatial autoregressive probit model that directly incorporates the social network structure to account for unobservable networking effects and potential reflection problem. A Bayesian estimation procedure is used to alleviate the convergence problem caused by the complexity of model specification. Empirical results show that the social learning effect positively influences the new technology adoption and was greater than herd behavior effect. The results also suggest that turf professionals rely more on suggestions and information from online social networking among themselves than recommendations from advisors.
La escuela pública: entre la compensación y la formación inclusiva
Authors: Durán Camelo Victor Hugo , Pinzón Alexandra Arias
Published: January 2024

Este artículo presenta las reflexiones derivadas de una investigación educativa sobre la inclusión como experiencia de transformación en el contexto de la escuela pública. Exhibe, relaciona y confronta el rol de los sujetos, el saber docente y las políticas de atención a la población escolar diversa. Metodológicamente, corresponde a una investigación de corte cualitativo-descriptivo realizada entre los años 2017 y 2019. Como instrumentos, se utilizaron diarios de campo y registros de observación participante de situaciones acontecidas en el contexto cotidiano de una escuela pública. Los resultados permiten comprender que el concepto de inclusión requiere una resignificación en el contexto escolar; la escuela, por su parte, muestra no estar preparada para asumir una perspectiva incluyente en los procesos pedagógicos y de gestión institucional. Finalmente, se observa que la política educativa no responde de manera asertiva a las características del contexto sociocultural-institucional ni a las particularidades de la población estudiantil observada.
Deseo, aceptación y voluntad de exterminio: sobre los fundamentos últimos de la violencia exterminista
Authors: Ribes Alberto Javier
Published: January 2024

La simple brutalidad exterminista es una de las constantes que caracterizan la historia moderna. El objetivo de este artículo es aproximarse a la comprensión de los fundamentos últimos de la violencia exterminista, es decir, a aquello que hay detrás del deseo y de la voluntad de exterminio. Para ello, se examinan las obras de Herbert Spencer, William G. Sumner y Joseph de Maistre. La estrategia que se adopta en estas páginas pretende transformar en presencias los acontecimientos de los últimos doscientos años, junto con los acontecimientos actuales, poniéndolos a todos en movimiento. En el artículo, se sostiene que las claves para entender este fenómeno residen en las relaciones complejas entre inclusión-exclusión/expulsión/exterminismo, que se ven atravesadas por un conjunto de discursos y prácticas: la competencia y la legitimación de la desigualdad, la jerarquía, la ontología de la muerte, la negación y las complicidades. Se concluye con la exposición típico-ideal de dos escenarios sociales y su relación con las dinámicas exterministas: uno basado en la inclusión y, el otro, en la exclusión/expulsión.
El deseo estaba puesto en la militancia. Paradojas y reapropiaciones de género en la experiencia de mujeres revolucionarias (Argentina, 1970)
Authors: Actis María Florencia
Published: January 2024

Introducción: el trabajo surge de la inquietud hacia las experiencias y formas de subjetivación de género de mujeres militantes de organizaciones armadas en la Argentina de los años 70. Se entiende que sus singulares derivas en mujeres-militantes constituyen procesos de interpelación crítica a las construcciones victimizantes presentes en las tecnologías (generizadas) de memorialización. Método: para su indagación y análisis, se realizaron entrevistas biográfico-narrativas con dos mujeres que ocuparon puestos de responsabilidad dentro de la organización político-militar Montoneros, en las que se hace hincapié en el entrecruce de sus experiencias políticas y personales. Resultados: si bien no eran todavía mujeres permeadas por la teoría de género, sus narrativas revelan una “actitud feminista ante la vida” y una radicalización performática de la premisa “lo personal es político”, en tanto las prácticas de militancia funcionaban —y hasta la actualidad— como lugares nodales, y privilegiados, de producción de deseo. Conclusión: las informantes, a través de su “hacer experiencia” militante, rearticularon formas novedosas de ser-mujeres, problematizando la ideación femenina como grupo identitario homogéneo y despolitizado.
Características de los estudios de crianza reflexiva en Colombia
Authors: Herrera Rivera Ovidio , Bedoya Cardona Ledy Maryory , Zapata Zapata Juan Esteban , López Pulgarín Sonia Elena
Published: January 2024

Objetivo: identificar las características de los estudios realizados sobre crianza reflexiva en Colombia durante los últimos 10 años. Método: la investigación es documental con enfoque cualitativo, al permitir un proceso comprensivo e interpretativo de investigaciones, artículos y libros vinculados al tema de estudio. Resultados: se encontró que los estudios realizados sobre la crianza reflexiva, en el contexto colombiano, adolecen de participación por parte de las instancias académicas, sociales y estatales; en este sentido, son escasas las investigaciones locales y nacionales que faciliten un desarrollo profundo sobre el tema. Discusión y conclusión: los artículos encontrados en el contexto local, nacional e internacional en el tema de estudio presentan características teóricas y prácticas con aportación valiosa al contexto de la intervención psicoterapéutica y psicoeducativa.
Influencia del origen social en el acceso a educación superior. El caso de trabajo social
Authors: Brand Monsalve Edinson Gabriel , Gómez Aristizábal Yenny Magaly , Lopera Osorio Natalia , Alvarez Calle Erika Yuliet
Published: January 2024

El propósito de este artículo es presentar los resultados de una investigación que evidencia cómo influye el origen social de los individuos en el acceso y logro de la educación superior y la integración al mercado laboral de un grupo de egresados de la Universidad de Antioquia, pertenecientes al programa de Trabajo Social de la seccional Oriente. En este estudio, se implementó una metodología integrada haciendo uso de la encuesta y la entrevista semiestructurada, con el fin de reconocer las características principales de la experiencia de los egresados y el sentido y significado de la misma. El principal hallazgo es que si bien las condiciones del origen social, caracterizadas por una baja disponibilidad de capital económico y cultural, generan situaciones limitantes para el logro educativo, de igual forma configuran situaciones habilitantes que, en función del aprovechamiento de diferentes recursos que ofrece el entorno, hacen posible la transformación del proyecto de vida de los individuos que se motivan por la educación superior, en respuesta al escenario de oportunidad que constituye la oferta educativa pública de calidad en el territorio.
Simulador de Ruído Acústico Submarino da Maquinaria de Navios para Aplicações em Sonar Passivo e Utilizando uma Rede Neural NARX
Authors: Santos Anderson , Sarno Filho Elio , Simas Filho Eduardo , Fernandes Júnior Antonio Carlos , Seixas José Manoel
Published: January 2024

Os sistemas de sonar passivo possuem aplicações abrangentes tanto em cenários civis quanto militares, desempenhando funçoes importantes, como a vigil ancia do ambiente submarino e a detecção de animais e embarcações. Devido à complexidade de obter dados acusticos submarinos, surge a necessidade de criar bancos de dados acusticos. No entanto, essa tarefa não é simples, pois requer a aquisição de equipamentos específicos e envolve custos consideraveis para instalação e manutenção. Tendo em vista a falta de dados relacionados aos ruídos acusticos submarinos, o objetivo deste artigo e apresentar um simulador que produz a combinação de ru ído de máquinas de embarcaçoes com ru ído ambiente a partir da descrição dos fenomenos f ísicos, utilizando modelos matematicos baseado em conceitos estatísticos e técnicas de aprendizado de máquina. Esse simulador visa preencher essa lacuna e permitir estudos e pesquisas nessa área.
Determination of Electricity Production by Fuzzy Logic Method
Authors: ÖZDEM Beyza , DÜĞENCİ Muharrem , İPEK Mümtaz
Published: January 2024

With the increase in the need for electrical energy, production amount planning is of great importance in order not to experience restrictions in terms of use, to meet the required electricity production, and to evaluate the excess production efficiently. In this study, a generation forecasting model was created with the fuzzy logic method to determine the electricity generation strategy. The created model is aimed to determine the electrical energy that needs to be produced daily by using the previous day's production amount, temperature, and season data. Three separate sets of data were used to test the fuzzy logic model built using information from the General Directorate of Meteorology (GDM) and Energy Markets Operations Inc. (EMOI). Fuzzy Logic was used to predict the data and the accuracy rates were found to be high. An improvement was observed when the accuracy rates were compared with the accuracy rates obtained in the Multiple Linear Regression Model. The accuracy rates of the model were initially examined using the Fuzzy Logic approach on weekdays and weekends, followed by a seasonal analysis and an assessment of the model's performance. As a result of the analysis, it was observed that the model worked with high accuracy in the autumn season and on weekend days.
Analysis of Morphometric Features and Development of a Regression Model for Predicting the Body Weight of Kuantan Cattle
Authors: Misrianti Restu , Ali Arsyadi , Zumarni Zumarni , Fitra Deni , Djuliyanto Erik , Andawaty Andawaty , Safira Nurul , Aswan Aswan
Published: January 2024

The Kuantan cattle, recognized as one of Indonesia's local breeds according to the Indonesian Ministry of Agriculture's Decree Number 1052/Kpts/SR.120/10/2014, were the focus of this study. The objective was to characterize morphometric features, estimate the body weight of Kuantan cattle through regression analysis based on body measurements, and compare the results with the School formula. The research was conducted in Pekanbaru and Kuantan Singingi Regency, using Kuantan cattle from Kuantan Singingi Regency (n=180) and UPT Pasir Putih, Dinas Peternakan dan Kesehatan Hewan, Riau Province (n=30). Morphometric parameters, including wither height, body length, and chest girth, were observed. Descriptive statistics (mean, standard deviation, and coefficient of variation) were used for data analysis. Regression equations were analyzed using SPSS 27. The findings indicated no significant morphometric differences between male and female Kuantan cattle. The body weight of Kuantan cattle could be predicted using single and combined body measurements as predictors. Chest girth (CG) emerged as the best predictor in the regression equation for single body measurement, with the highest values of r (0.98), R2 (0.96), and Adj R (0.95) in males, and r (0.88), R2 (0.78), and Adj R (0.77) in females. In combined predictors, the combination of CG and wither height (WH) yielded the highest values for r (0.99), R2 (0.99), and adj R (0.99) in males, and r (0.92), R2 (0.91), and adj R (0.83) in females. The most accurate prediction of body weight in Kuantan cattle was achieved by combining two body measurements, CG and WH. Using the regression equation for estimating body weight proved to be more accurate than the School formula
PHYSICAL AND ORGANOLEPTIC CHARACTERISTICS OF TAMARIND PASTE (Tamarindus Indica L) WITH MODIFIED ELEPHANT CASSAVA (Manihot Esculenta) DERIVATIVE PRODUCT THICKENER
Authors:   Universitas Mulawarman, Rahayu Putri Nanda , Prabowo Sulistyo ,   Universitas Mulawarman, Rachmawati Maulida ,   Universitas Mulawarman
Published: January 2024

This research was conducted to determine the effect of physical properties on elephant cassava derivative products as a thickener for tamarind paste. This study used a non-factorial completely randomized design (CRD) with 2 treatments, namely types of thickener (modified starch and mocaf) at 5 different concentrations (0%, 1%, 3%, 5%, and 10%) with 3 repetitions. The addition of 10% elephant cassava mocaf flour had the highest value based on the viscosity test with a value of 5624 mPas, in the 10% solubility test the addition of modified starch has a value of 90.47%, the speed with heating at 80℃ ranges from 45-66 seconds and the organoleptic test for taste attributes is 2.04- 2.48.
CHEMICAL AND ANTIOXIDANT CHARACTERISTICS OF FERMENTED YELLOW PUMPKIN FLOUR WITH VARIATION OF MICROORGANISMS AND FERMENTATION TIME
Authors:   Universitas Semarang, Sari Anisa Rachma , Putri Aldila Sagitaning ,   Universitas Semarang, Gunantar Devy Angga ,   Universitas Semarang
Published: January 2024

Pumpkin flour produced through fermentation can increase its nutritional value. This study aims to analyze the chemical characteristics and antioxidants of fermented pumpkin flour with variations in microorganisms and fermentation time, as well as the correlation between the two factors, and determine the best formulation. This study used a factorial group randomized design method with two factors, namely, variation of microorganism and fermentation time. The data obtained were analyzed using factorial ANOVA, followed by the Duncan Multiple Range Test (DMRT) test with a confidence level of 95% using SPSS 23. The chemical characteristics of fermented pumpkin flour showed an interaction between fermentation microorganisms and the length of fermentation time on the antioxidant activity of fermented pumpkin flour, but there was no interaction between fermentation microorganisms and the length of fermentation time on the moisture content, ash, protein, fat, and carbohydrates of fermented pumpkin flour. Fermentation by S. cerevisiae for 3 days had the best chemical characteristics and antioxidant activity of fermented pumpkin flour. Researchers hope that the application of fermentation in processing pumpkin into flour can increase the nutritional value, the economic value, and the value of health.
MICROBIAL SUCCESSION DURING THE FERMENTATION OF SEMERU ARABICA COFFEE IN WINE COFFEE PRODUCTION
Authors:   Universitas Brawijaya, Sriherfyna Feronika Heppy , Khairanny Neysa Nurjananah ,   Universitas Brawijaya, Nurcholis Mochamad ,   Universitas Brawijaya, Maligan Jaya Mahar ,   Universitas Brawijaya
Published: January 2024

The current trend in coffee product diversification is wine coffee, which has a wine-like flavor and aroma. Reviews of wine coffee are still limited, especially those related to microbial succession during the fermentation process. The objective of this research was analyzing the microbial population and the effect of microbial succession during fermentation process of Arabica Semeru coffee. The analysis was conducted by identifying microbes microscopically and macroscopically. The results of microbial identification during the 30-day fermentation showed populations of yeast, lactic acid bacteria, and acetic acid bacteria. Along with the length of fermentation time, the temperature decreased and the pH fluctuated and stabilized after 16 days of fermentation. There was an increase in sugar and protein content, from 0.61% to 2.87% and 2.13% to 2.23%, respectively. The ethanol content reached 0.047% at the end of fermentation. The microbial exploration was required for further investigation in understanding its role during fermentation process.
Is Targeting Inflammation the Key to Unlocking HFpEF? : Focus on Anti-Inflammatory Therapy
Authors: Reventia Yurista Salva , Sargowo Djanggan
Published: January 2024

Chronic inflammation plays a crucial role in the formation of atherosclerosis and is also associated with the advancement of heart failure. Clinical and epidemiological evidence has increasingly supported the link between low-grade inflammation and heart failure with preserved ejection fraction (HFpEF). From a fundamental scientific standpoint, inflammation in HFpEF has notable detrimental impacts on the endothelium and the microvasculature of the heart. HFpEF clinical studies focusing on inflammation are a sign of hope because they show a shift toward treating the condition's cause instead of just its symptoms.
Motherhood as Experienced by Women in a Prenatal and Early-Childhood Home Visitation Program, and Associated Factors
Authors: Lee Ji Yun , Khang Young-Ho , Kim Yu-Mi , June Kyung Ja , Cho Sung-Hyun , Cho Hong-Jun
Published: January 2024

Purpose: This study is intended to examine the difficulties facing mothers of young children (early childhood) and to understand the associated factors.Method: We analyzed 1,003 data items of women with children under age 2 who participated in a prenatal and early-childhood home visitation program in Seoul from 2016 to 2019. For our research, we used self-administered registration and service monitoring data. The difficulties the women faced as mothers were measured using the “Being a Mother Scale” (BaM-13). This analysis considered covariates including maternal and infant ages, their number of children, economic conditions, presence of disabilities, single motherhood, multicultural migration background, employment status, unintended pregnancy, instrumental and emotional support, and depression scores.Results: The average score for being a mother was 14.45 (standard deviation=6.61), and higher scores were recorded for women with spouses, Korean women (as opposed to multicultural immigrant women), women whose pregnancies were unplanned, women without instrumental support, and severely depressed women.Conclusion: Motherhood poses great difficulties to women with children under age two. To help women transition from motherhood, it is important to understand their situations in relation to their social and psychological characteristics, as well as the cultural, social, and contextual perspectives they bring to motherhood.
Family-Centered Care for High-Risk Infants and the Roles of Healthcare Professionals
Authors: Im Yeo Jin , Park Young-Ah
Published: January 2024

With an increasing trend toward low birth rates and premature births, the importance of managing the health of high-risk infants has received constant emphasis. It is necessary to establish a family-centered care culture in neonatal intensive care units where high-risk infants are hospitalized. This study is intended to examine the current status of family-centered care and the direction of the role played by healthcare professionals, focusing on the characteristics of high-risk infants and their families. Healthcare professionals should listen to the needs of the family and facilitate their involvement to improve the performance of family-centered care and systematic support. Specific guidelines are required to strengthen the competence and leadership of healthcare professionals. The paradigm shift toward family-centered care for high-risk infants is a challenge for healthcare professionals and parents, but it will serve as a vision and strategy to improve the health of high-risk infants and their families by including the family in the healthcare process.
The Impact of Parental Electronic Health Literacy on Disease Management and Outcomes in Pediatric Type 1 Diabetes Mellitus: Cross-Sectional Clinical Study
Authors: Hölgyesi Áron , Luczay Andrea , Tóth-Heyn Péter , Muzslay Eszter , Világos Eszter , Szabó Attila J , Baji Petra , Kovács Levente , Gulácsi László , Zrubka Zsombor , Péntek Márta
Published: January 2024

Background

Despite the growing uptake of smart technologies in pediatric type 1 diabetes mellitus (T1DM) care, little is known about caregiving parents’ skills to deal with electronic health information sources.

Objective

We aimed to assess the electronic health literacy of parents caring for children with T1DM and investigate its associations with disease management and children’s outcomes.

Methods

A cross-sectional survey was performed involving 150 parent-child (8-14 years old with T1DM) dyads in a university pediatric diabetology center. Parents’ electronic health literacy (eHealth Literacy Scale [eHEALS]), general health literacy (Chew questionnaire and Newest Vital Sign [NVS]), and attitudes toward T1DM care (Parental Self-Efficacy Scale for Diabetes Management [PSESDM] and Hypoglycemia Fear Survey [HFS]) were investigated. Children’s treatment, HbA1c level, and quality of life (Pediatric Quality of Life Inventory Diabetes Module [PedsQL Diab] and EQ-5D-Y-3L) were assessed. Multiple linear regression analysis was performed to investigate the determining factors of 6-month average HbA1c.

Results

Of the 150 children, 38 (25.3%) used a pen, 55 (36.7%) used a pen plus a sensor, 6 (4.0%) used an insulin pump, and 51 (34.0%) used an insulin pump plus a sensor. Parents’ average eHEALS score (mean 31.2, SD 4.9) differed significantly by educational level (P=.04) and the children’s treatment (P=.005), being the highest in the pump + sensor subgroup. The eHEALS score showed significant Pearson correlations with the Chew score (r=−0.45; P<.001), NVS score (r=0.25; P=.002), and PSESDM score (r=0.35; P<.001) but not with the children’s HbA1c (r=−0.143; P=.08), PedsQL Diab (r=−0.0002; P>.99), and EQ-5D-Y-3L outcomes (r=−0.13; P=.12). Regression analysis revealed significant associations of the child’s HbA1c level with sex (β=0.58; P=.008), treatment modality (pen + sensor: β=−0.66; P=.03; pump + sensor: β=−0.93; P=.007), and parents’ self-efficacy (PSESDM; β=−0.08; P=.001).

Conclusions

Significantly higher parental electronic health literacy was found in T1DM children using a glucose sensor. The electronic health literacy level was associated with parents’ diabetes management attitude but not with the child’s glycemic control. Studies further investigating the role of parental electronic health literacy in T1DM children managed at different levels of care and the local context are encouraged.
Evaluation of Prompts to Simplify Cardiovascular Disease Information Generated Using a Large Language Model: Cross-Sectional Study
Authors: Mishra Vishala , Sarraju Ashish , Kalwani Neil M , Dexter Joseph P
Published: January 2024

In this cross-sectional study, we evaluated the completeness, readability, and syntactic complexity of cardiovascular disease prevention information produced by GPT-4 in response to 4 kinds of prompts.
Efficacy of BrighterSide, a Self-Guided App for Suicidal Ideation: Randomized Controlled Trial
Authors: Josifovski Natasha , Torok Michelle , Batterham Philip , Wong Quincy , Beames Joanne R , Theobald Adam , Holland Sarah , Huckvale Kit , Riley Jo , Cockayne Nicole , Christensen Helen , Larsen Mark
Published: January 2024

Background

Self-guided digital interventions can reduce the severity of suicidal ideation, although there remain relatively few rigorously evaluated smartphone apps targeting suicidality.

Objective

This trial evaluated whether the BrighterSide smartphone app intervention was superior to a waitlist control group at reducing the severity of suicidal ideation.

Methods

A total of 550 adults aged 18 to 65 years with recent suicidal ideation were recruited from the Australian community. In this randomized controlled trial, participants were randomly assigned to receive either the BrighterSide app or to a waitlist control group that received treatment as usual. The app was self-guided, and participants could use the app at their own pace for the duration of the study period. Self-report measures were collected at baseline, 6 weeks, and 12 weeks. The primary outcome was severity and frequency of suicidal ideation, and secondary outcomes included psychological distress and functioning and recovery. Additional data were collected on app engagement and participant feedback.

Results

Suicidal ideation reduced over time for all participants, but there was no significant interaction between group and time. Similar improvements were observed for self-harm, functioning and recovery, days out of role, and coping. Psychological distress was significantly lower in the intervention group at the 6-week follow-up, but this was not maintained at 12 weeks.

Conclusions

The BrighterSide app did not lead to a significant improvement in suicidal ideation relative to a waitlist control group. Possible reasons for this null finding are discussed.
Analysis of Audit Failure of Yu Diamond by Asia Pacific Certified Public Accountants
Authors: Wang Wanqi
Published: January 2024

Since the 18th National Congress of the Communist Party of China, China has always adhered to and deepened its unique financial roadmap to ensure the efficient operation and high-quality development of the financial industry. At the same time, we are also constantly improving our financial supervision and management system. With the establishment of the whole process registration system, the need for the legal construction and the later monitoring and control restrictions of the capital market has become more urgent. Because the capital market is established based on the openness and transparency of information, accounting firms play key roles in this field.—As “gatekeepers” to ensure the accuracy and integrity of financial information, which is of vital significance to maintaining the stable and healthy development of the capital market. This paper takes the audit case of Zhengzhou Huajing diamond by Asia-Pacific Accounting firm as the research object, according to the defects in the audit, and puts forward countermeasures and suggestions for the audit, aiming to provide certain reference value for reducing the audit failure.
Численность обучающихся в системе высшего образования: статистический анализ данных по Республике Калмыкия на фоне общероссийских данных
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Badmaeva Nogan B.
Published: January 2024

Education is the most important indicator of the development of the country and its regions. The sustainability of regional development directly depends on the intellectual potential of the region. The purpose of the article, based on the analyzes of the statistical data on the number of students in the higher education system, is to consider the problems and trends in the development of higher education in the country as a whole and in the Republic of Kalmykia in particular. Materials and methods. The following materials were used when writing the article: statistical data from the Ministry of Higher Education and Science of the Russian Federation, Federal State Statistics Service, statistical (analytical) reviews of the Institute of Statistical Research and Economics of knowledge of the National Research University “Higher School of Economics”. The methods of system-structural and statistical data analysis were applied in the study. Results. Statistical data reflect the social and economic processes taking place in the society. The data reviewed on the number of higher education institutions, their forms of ownership, the number of students and their preferred forms of education showed that in recent years the country has been experiencing the process of increasing the state control in the field of higher education expressed in the reduction of the number of universities, especially private ones, as well as in the reduction of the number of their branches, etc. In Kalmykia, as well as in the country as a whole, the number of students decreased between 2018 and 2022. Also in the republic, as well as in the country, after the active growth of the number of non-governmental higher education institutions and their branches in the early 2000s, already in 2014–2015 their quantity decreased sharply. There is also a tendency in the region to reduce the number of full-time students while increasing the number of part-time students. At the same time, the number of students studying by correspondence throughout the country is decreasing. Statistics have shown that the number of correspondence students is growing at the expense of students from the neighboring regions that can be explained by the low cost of the tuition.
Обзор архивных материалов фонда Р-218 Национального архива Республики Калмыкия
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Shikhanov Namsyr A.
Published: January 2024

Introduction. The article discusses the description and analysis of the archival fund, which is stored in the National Archive of the Republic of Kalmykia. The purpose of the study is to give a complete analysis and introduce the archival fund R-218 into scientific circulation. The materials were archival inventories of the fund R-218 “Kalmyk Design and Construction Department of Highways of the Kalmyk ASSR” of the National Archive of the Republic of Kalmykia, dedicated to the subject under study. Results. 16 archival inventories of the R-218 fund have been studied. The archival material of the foundation shows the creation and development of the road economy in Kalmykia, design estimates for the construction and repair of roads of national and local significance.