bluuebunny/crossref_metadata_2025 huggingface dataset:
AUDIT FEATURES OF THE FIRST IFRS FINANCIAL STATEMENTS
Authors: Lyubenko A. , Znak N. , Karpachova O.
Published: April 2022

Abstract. This article focuses on the financial audit of the first financial statements prepared in accordance with International Financial Reporting Standards (IFRS). Also, the article examines the requirements for the training, maintenance and design of workers in accordance with International Standards on Auditing (ISA) 230 «Audit documentation».
The article identifies the main objectives, relevance and need for an audit of the first IFRS financial statements. The main sources of information for such an audit have been formed.
The article analyzes the requirements for the first IFRS financial statements. Based on these requirements, the criteria are formed according to which the auditor will check the correctness of the transition of the company from national to international standards. Also, the main audit procedures that will be applied by the auditor in performing such an audit are identified.
The research identified the importance of an audit of IFRS accounting policies. The criteria by which the auditor will verify the compliance of the applied accounting policy with the requirements of international standards are defined.
The article identifies and analyzes the role of proper use of reasonable cost in the transition to international standards. There are requirements for such application, which will be important when auditing the correctness of the first IFRS financial statements.
The article provides an overview of the transformation file of the transition to IFRS as one of the important sources of information for the audit. The procedure of transition from national to international standards with the help of a transformation file is analyzed. The importance of the auditor’s use of such a transformation file is determined.
The research of the audit of the first financial statements in accordance with IFRS, allowed to form the requirements for audit documentation in accordance with the requirements of ISA. The main composition of the audit documentation that the auditor should have upon completion of the audit of the first IFRS financial statements is indicated.
Keywords: audit, auditor’s report, IFRS, ISA, IFRS financial statements.
JEL Classification M41
Formulas: 0; fig.: 2; tabl.: 1; bibl.: 13.
АНАЛІЗ СУЧАСНОЇ СИСТЕМИ УПРАВЛІННЯ ПЕРСОНАЛОМ ПІД ВПЛИВОМ ЦИФРОВІЗАЦІЇ БІЗНЕС-ПРОЦЕСІВ: ДОСВІД МІЖНАРОДНИХ КОМПАНІЙ, УКРАЇНСЬКІ РЕАЛІЇ
Authors: Гуржій Н. , Гурман O. , Леськова С. , Тягунова З. , Любецька М.
Published: April 2022

Анотація. Досліджується розвиток сучасної системи управління персоналом під впливом цифровізації, яка в останні роки прискорила темпи розвитку, це перш за все було викликано поширенням короновірусної інфекції, яка завдала загрози функціонуванню багатьох підприємств та економіки країни в цілому. Цифрові зміни, що відбуваються в економіці, відкривають можливість модернізації технології роботи з працівниками, що може значно підвищити ефективність роботи компанії. Нині підприємства почали впроваджувати у свою діяльність цифрові технології, які спрощують і підвищують ефективність управління персоналом. Зазначено, що на сучасному етапі розвитку управлінням персоналу для працівників створюються умови, які підвищують мобільність в ухваленні рішень, наприклад для того, щоб керівник проєкту відслідковував його виконання, йому не обов’язково перебувати на підприємстві, він зможе через програмне забезпечення подивитися показники КРІ кожного співробітника. Підвищення кваліфікації робітників також набуває нових можливостей, за рахунок створення курсів, лекцій та семінарів, які можуть проходити підлеглі в будь-який час. Слід відзначити, що також на цьому етапі можна проводити збори керівництва в комфортний для кожного час. Для цифровізації управління персоналом характерні такі принципи: гнучкий підхід до розвитку співробітників; систематична відповідність цілям підприємства; інтеграція менеджменту та власників бізнесу в загальну систему управління; розширена мотивація; персонал розглядається як інвестиція, яку потрібно розвивати; використання потенціалу під час працевлаштування; переважання робочих груп і проєктних груп над традиційними структурними підрозділами; проактивна функція інновацій; стимулювання змін. Постійно зростаюча кількість мережевих команд і співробітників за короткостроковими контрактами у світі дозволяє багатьом галузям швидко впроваджувати бізнес-процеси на основі HR-трансформації. Було досліджено досвід міжнародних компаній у контексті цифровізації управління персоналом та визначено показники, які демонструють ефективність упровадження новітніх технологій.
Ключові слова: діджиталізація, персонал, підприємство, технології, процеси, відповідальність.
Формул: 0; рис.: 2; табл.: 1; бібл.: 13.
TRUST IN THE FINANCIAL SECTOR: A NEW APPROACH TO CONCEPTUALIZING AND MEASURING
Authors: Onyshchenko S. , Brychko М. , Litovtseva V. , Yevsieieva A.
Published: April 2022

Abstract. In the new global economy, public trust in the financial system has become a central issue for financial crises overcoming. There is evidence that trust plays a crucial role in regulating economic agents' relationships. One of the most significant challenges for research is developing the unified methodological basis for element and integrated assessment of public trust level in the financial sector. This study intends to develop the methodology of public trust assessment in the financial sector at all levels, taking into account quantitative and qualitative indicators. This article examines the scientific and applied aspects of qualitative and quantitative assessment methods based on surveys of economic agents and economic-mathematical modeling tools, analyzing the researchers experience and outlines methodological approaches to assessing the public trust in the financial system in modern conditions. Important aspects are outlined, and the advantages and disadvantages of the different approaches for element and integrated assessment of public trust on different levels of the financial system are systematized.

In order to estimate the public trust in the financial system, the multidimensional factor analysis was conducted based on a set of standardized financial indicators for the period from 2010 to 2020. Multidimensional factor analysis employed for data processing and analysis was performed in the computational system STATISTICA. The multidimensional factor analysis results show that trust in the financial sector was grouped into three levels: macro-, mezo-, and micro-level. The results show that the increase in nominal salary and an increase in the share of deposits and loans in the national currency in the loan and deposit portfolio of deposit-taking corporations are statistically significant and positively affect the level of trust in the financial sector. However, the deepening crisis of trust, in turn, is due to the dollarization of the banking sector, increasing the growth of cash outside deposit-taking corporations. The scientific novelty of the obtained results is represented by a set of theoretical and practical aspects of the study, namely the methodology of public trust assessment in the financial sector at all levels of manifestation, taking into account quantitative and qualitative indicators.

Keywords: public trust in the financial sector, integrated assessment, element-by-element assessment, factor analysis, levels of public trust in the financial sector, monetary authority, financial institutions, financial services

Formulas: 4; fig.: 6; bibl.: 32.
STRATEGI PEMERINTAH DALAM PENINGKATAN KUALITAS SUMBER DAYA MANUSIA PADA GENERASI MUDA DESA COMPONG
Authors: Syahda Ana Satria , Yasin Ahmad , Barisan Barisan , Buhari Buhari , Tamrin Muh
Published: April 2022

This study aims to determine the Government's Strategy in Improving the Quality of Human Resources in the Young Generation of Compong Village, Pitu Riase District, Sidenreng Rappang Regency by using qualitative descriptive research and using data collection techniques, namely interviews, observations, and documents. The results showed that the strategy carried out by the government, especially in the village of Compong, was still lacking in terms of increasing human resources, especially for the younger generation in the village. There are still many young people in the village of Compong who need more support from village government officials, especially from the village head himself. The village head must play an important role in improving the quality of the younger generation, the younger generation cannot develop if the village officials, especially the village head, have not been able to master the things that are important for the young generation in the village of Compong. There are many ways that can be done or used as a strategy for the village government if the village apparatus is able to explore what is the obstacle for the younger generation so that they have not been able to help the village apparatus in improving the good name of the village.
KEBIJAKAN PEMERINTAH TERHADAP PENERAPAN APLIKASI AGRIBISNIS STORE DI DESA PATTONDON SALU
Authors: S Anita , Jabbar Abdul , Hakim Akhyaruddin , Herman Bahtiar , Kamal Kamal
Published: April 2022

The purpose of this research, to find out Governent Policy on the application of Agribusiness Store in the Village of Pattondon Salu, Maiewa District, Enrekang Regency, the data analysis technique used is descriptive statistics using data collection technique including questionnaire, interview, and observation. The population in this study were 2.380 people and the sampling used was probability sampling with a random sampling technique in order to obtain a sample of 88 people. Data analysis was performed with the help of the SPSS 21 program. The results of this study indicate that the planning of government policies on the application of agribusiness store aplications, in the Village of Pattondon Salu, Maiwa District, Enrekang regency, is at a percentage of value t count  ≥ t table  (5,024> 1,6627) with Y = 4,676 +  0,277 X  or is the good category, while the aplications of agribusiness store applications is at a percentage of 86 % with an ideal 86,33% from 100% which is expected or is in the  good category. Each indicator  is in the good category with the percenatage of the producer role indicator at 88%, and the media role indicator at 86%.
ANALISIS KEBIJAKAN PENGARUS UTAMAAN GENDER DALAM PEMBANGUNAN DI PEMERINTAH KABUPATEN SLEMAN
Authors: Rahmawati Agustina , Nugroho Hanantyo Sri
Published: April 2022

Artikel ini mengkaji tentang paradigma pembangunan yang ber respektif gender pa a pemerintah daerah. Masalah ini menarik untuk diteliti karena terdapat bias ketidakadilan pada proses maupun hasil pembangunan, dimana menempatkan perempuan bukan sebagai sasaran dan aset pembangunan, melainkan sebagai beban pembangunan. Setidaknya penelitian ini menggunakan prespektif Women in Development (WID) dalam menganalisis di Pemerintah Daerah. Selanjutnya, metode yang digunakan adalah metode deskriptif kualitatif. Pada metode deskriptif kualitatif harus memperhatikan validasi data. Oleh karena itu, penelitian ini menggunakan triangulasi data. Adapun tujuan penelitian ini adalah mengetahui kebijakan Pemerintah Kabupaten Sleman dalam mewujudkan peran produktif bagi perempuan dalam pembangunan. Temuan hasil penelitian ini yaitu adanya kebijakan dan program yang berspektif gender di Pemerintah K bupaten Sleman seperti pembentukan daerah PUG, pembentukan Kabupaten Layak Anak (KLA) serta capaian apresiasi APE tingkat mentor.
Kebijakan Relokasi Warga Kampung Pulo
Authors: Rukmo J. Endi , Amazinhono Memorianus
Published: April 2022

Relocation policy of Kampung Pulo is one program of Prevention Policy flooding in Jakarta. The flooding problem is a problem that is always faced by the provincial goverment of Jakarta on every rainy season. This issue became one of the priorities of Jokowi-Ahok when campaingning in Jakarta gubernatorial election three years ago. With the buzz and courage Governor of Jakarta was the eviction of the houses in Kampung Pulo remain to be implemented, which previously had to be disseminated to the public. Execution of the program resulted in a clash between Satpol PP with residents who cause casualities. Residents of Kampung Pulo throught mass organizations Ciliwung Merdeka preparing a lawsuit against the goverment of Jakarta to prove ownership of their land in Kampung Pulo

Kampung Pulo land ownership history that began before 1930 or the Dutch colonial period Verponding basic land ownership is that the bill on the land and buildings (girik) in the Dutch colonial era. Based on the letter of citizens must convert the letter through the National Agricultural Operation Project (PRONA), since the 1960 Agarian Law to admit it. Eviction of houses is aimed at the normalization of Ciliwung. The normalization efforts started in 2013, when still a Governor Jokowi. According to the agreement the citizens want Rusunawa not far from its original home. Ahok decision was considered controversial. He is considered to be violating human rights while continuing evictions especially as the conflit and victims of the citizens, but the decisibe acation Ahok should be appreciated. Ahok do to do a Governor to address the problems in the region and in the public interest
Tinjauan Tentang Keberadaan Lembaga Negara Non Struktural Dalam Sistem Pemerintahan Indonesia
Authors: Rosidi Rosidi
Published: April 2022

The emergence of the phenomenon of the presence of non-structural institution (LNS) indicates that there are still many problems that can not be solved by State institutions that exist, so the presence of non-structural institution is still needed and does not conflict with the Constitution of 1945. The presence of LNS cause problems including the overlap (overlapping) between LNS with LNS authority or other state institutions. Likewise, the legal basis for the establishment of very varide.

Analysis of the problem that needs to be done is mapping the LNS and an exsting state agency so as to avoid overlapping. The legal basis for the establishment of uniform LNS in the form of law, goverment regulation, Decree of the President or the Presidential Decree. In addition, the feasibilty of establishing LNS is done based on Kolabarasi thingking among goverments, communities and businesses that its presence is highly expected by all parties.
Digital Enhancements for Primary Medical Manuscripts: A Survey on Perceptions, Challenges, and Needs of Medical Publication Professionals
Authors: Fonseca Patricia
Published: April 2022

Given their potential for engaging audiences, there has been increasing interest recently in the use of digital enhancements, such as video abstracts and infographics, for primary publications in peer-reviewed medical journals. However, their uptake by authors and sponsors of medical publications has been mixed, with few top journals offering the possibility of publishing digital enhancements beyond supporting slides and lay summaries. Digital enhancements for primary manuscripts may provide new opportunities for medical writers to expand their skills and services, but it is unclear whether medical writers receive and accept requests to develop digital enhancements regularly and what training they need to generate high-quality deliverables for their clients. Understanding the perspectives of medical publication professionals and their clients on digital enhancements for peer-reviewed journals may help address misconceptions and concerns and identify more effective ways to create auxiliary digital content to support the dissemination of research findings. Here, a survey was conducted to gauge the overall interest in accompanying digital enhancements among medical publication professionals and their perception of their clients’ needs, determine the perceived value of these features, and identify barriers in development. The survey was created and posted on AMWA Engage, AMWA New England Chapter E-News, LinkedIn, and the MedComms Networking webpage. A total of 116 respondents completed the survey. About half had developed digital enhancements for primary publications, mostly for pharmaceutical companies, medical communication agencies, and other nonacademic organizations. Infographics and visual abstracts were the most frequently requested type of enhanced content. Although the respondents recognized the importance of digital enhancements to facilitate data visualization, approximately half reported not having specific training or experience to enable them to accept such assignments. For their clients, the main reasons given for not developing digital enhancements were cost and time constraints, lack of interest, and author unavailability.
Pengaruh Faktor-faktor Bauran Promosi Online terhadap Kepuasan Pengguna dan Keputusan Penggunaan Kembali Aplikasi Grabfood (Studi Kasus pada Pengguna Grabfood Kota Gresik)
Authors: Fitrian Rizal , Balafif Mamak , Musriha Musriha , Retnowati Nova
Published: April 2022

Layanan pesan antar makanan secara online semakin diminati, dikarenakan konsumen tidak perlu repot lagi untuk mendatangi lokasi dan mengantri. Sehingga mereka hanya tinggal menunggu di rumah atau di tempat tujuan pesanan tersebut diantarkan. Salah satu perusahaan yang bergerak di bidang jasa pesan antar makanan yaitu Grab Food. Menerapkan strategi pemasaran yang tepat dengan tujuan untuk meningkatkan kepuasan dan keputusan pembelian, salah satunya yaitu melakukan bauran promosi. Penelitian ini dibuat bertujuan untuk mengetahui dan membuktikan pengaruh faktor-faktor bauran promosi terhadap kepuasan pengguna dan keputusan penggunaan kembali aplikasi Grab Food di Kota Gresik. Penelitian ini bersifat deskriptif dan kausalitas dengan 270 responden sebagai objek penelitian. Responden adalah masyarakat kota Gresik yang pernah menggunakan layanan grabfood. Teknik analisis yang digunakan adalah analisis jalur. Hasil penelitian memperoleh simpulan bahwa faktor-faktor bauran promosi yang terdiri dari advertising, sales promotion, public relation, personal selling dan direct marketing berpengaruh signifikan terhadap Kepuasan Pengguna dan keputusan penggunaan kembali aplikasi grabfood di kota Gresik.
Pengaruh Motivasi, Pelatihan dan Kompensasi terhadap Kepuasan Kerja dan Kinerja Karyawan pada PT. Graha Prima Indonesia di Sidoarjo
Authors: Bani Mochammad Nashir Khakim Asya’ , Widyaningrum Mahmudah Enny , Rosyafah Siti , Haryono Haryono
Published: April 2022

Penelitian ini bertujuan untuk: (1) membuktikan dan menganalisis pengaruh motivasi, pelaatihan dan kompensasi terhadap kepuasan kerja; (2) membuktikan dan menganalisis pengaruh motivasi, pelaatihan dan kompensasi terhadap kinerja karyawan; dan (3)  membuktikan dan menganalisis pengaruh kepuasan kerja terhadap kinerja karyawan PT. Graha Prima Indonesia Sidoarjo. Sampel dalam penelitian ini diambil sebanyak 71 sampel yaitu 71 karyawan pada PT. Graha Prima Indonesia Sidoarjo. Teknik analisis data menggunakan analisis jalur (path analysis) dengan software SPSS (Statistical Package for Social Science) versi 22. Kesimpulan dari penelitian ini, yaitu sebagai berikut: (1) motivasi berpengaruh signifikan terhadap kepuasan kerja; (2) pelatihan berpengaruh signifikan terhadap kepuasan kerja; (3) kompensasi berpengaruh signifikan terhadap kepuasan kerja; (4) motivasi berpengaruh signifikan terhadap kinerja karyawan; (5) pelatihan berpengaruh signifikan terhadap kinerja karyawan; (6) kompensasi berpengaruh signifikan terhadap kinerja karyawan pada PT. Graha Prima Indonesia Sidoarjo.
Bentuk Perlindungan Hukum Pelaku Usaha Pesaing terhadap Posisi Dominan dalam Penerapan Rule of Reason
Authors: Makka Zulvia
Published: April 2022

Penelitian ini bertujuan untuk menganalisis perlindungan hukum pelaku usaha pesaing terhadap penyalahgunaan posisi dominan yang dilakukan oleh pelaku usaha yang memiliki kekuatan secara ekonomi yang memungkinkan untuk beroperasi di pasar tanpa terpengaruh oleh persaingan dan melakukan tindakan yang dapat mengurangi persaingan, serta penerapan azas rule of reason dalam posisi dominan sesuai dengan ketentuan Undang-Undang Nomor 5 Tahun 1999 tentang Larangan Praktik Monopoli dan Persaingan Usaha Tidak Sehat. Metode yang digunakan adalah metode penelitian normatif. Penelitian ini menunjukkan bahwa perlindungan yang diberikan kepada pelaku usaha pesaing adalah dapat melaporkan ke Komisi Pengawas Persaingan Usaha (KPPU), dalam hal ini KPPU dalam penerapannya dapat menggunakan azas rule of reason.
Kata Kunci: Dominan; Rule reason; Perlindungan.
 
AbstractThis study aims to analyze the legal protection of competing business actors against abuse of dominant position by business actors who have economic power that allows them to operate in the market without being affected by competition and take actions that can reduce competition, as well as the application of the rule of reason principle in a dominant position. In accordance with the provisions of law number 5 of 1999 concerning the prohibition of Law Number 5 Year of 1999 concerning the prohibition of monopolistic practices and unfair business competition. The method used is normative research method. This research shows that the protection given to competing business actors is that they can report to the KPPU, in this case KPPU in its application could use the rule of reason principle.
Keywords: Dominant; Rule Reason; Protection.
Characterization of hydrocarbon degrading microorganisms from Glycine max and Zea mays phytoremediated crude oil contaminated soil
Authors: Njoku Kelechi L , Ude Eme O , Jegede Temitope O , Adeyanju Omotoyosi Z , Iheme Patricia O
Published: April 2022

Microbe-plant partnership in phytoremediation involves a synergistic interaction that leads to degradation of contaminants. The identification and characterization of these microorganisms is fundamental in environmental management. This study is aimed at investigating the influence of Glycine max and Zea mays on microbial make-up and differentiation of soil bacterial and fungal isolates in crude oil contaminated soil. We employed conventional technique of microbial isolation and gene sequencing to evaluate the microbial composition in crude oil contaminated soil. The microorganisms were isolated from crude oil contaminated soil (0%, 4%, 8%) and were identified using 16S rRNA gene (for bacteria) and Internal Transcribed Spacer (ITS) gene (for fungi). We observed a change in the microbial cell density with respect to treatment conditions implying a shift in microbial dynamics to total hydrocarbon utilizing bacteria as the dominant microbes. The sequence data revealed five bacteria strain; Klebsiella aerogenes strain 77, Klebsiella aerogenes strain UISO178, Salmonella enterica strain ABUH7, Klebsiella aerogenes strain M242 and Enterobacter sp. NCCP-607 and three fungi strains; Galactomyces geotrichum strain CBS, Aspergillus niger strain YMCHA73 and Trichoderma virens isolate A701. Annotation analysis using FGENESB and gene scan revealed proteins involved in various metabolic processes and hydrocarbon utilization. GHOSTKOLA output revealed several genetic elements and pathways such as DnaA, PYG, mrcA, environmental, cellular and genetic information processing and degradation enhancers. Our findings show that G. max and Z. mays in association with bacteria can enhance ecosystem restoration of crude oil contaminated soil.
Prevalence of Microalbuminuria and Its Association with Severe Urinary Reflux and Renal Scarring with Reflux Nephropathy in Children Aged Less Than 12 Years in Ilam, Iran
Authors: Mohammadi Kamalvand Mehrnoosh , Taherpour Farshad , Shafiei Elham , Mamizadeh Nahid , Mohammadi Jasem
Published: April 2022

Background: Vesicoureteral reflux is a common urinary tract abnormality, which could damage the renal parenchyma. The present study aimed to investigate the prevalence of microalbuminuria and its association with the severity of urinary reflux and renal scarring with reflux nephropathy in children aged less than 12 years referred to Imam Khomeini Hospital in Ilam, Iran. Methods: This longitudinal study was conducted during one year on the hospitalized patients who had tested positive for urine and urine culture. After the treatment of urinary tract infection and obtaining a negative urine culture, isotope cystography or radiographic cystography was performed to diagnose urinary reflux. Data analysis was performed in SPSS version 20 using descriptive statistics, chi-square, and correlation-coefficients. Results: The prevalence of microalbuminuria in Ilam province was 35.7%. No significant difference was observed between the rates of microalbuminuria and reflux (P > 0.05). However, the inverse correlation in this regard was not considered significant (P > 0.05). A direct correlation was observed between the rate of microalbuminuria and the incidence and severity of scars, which was considered significant (P < 0.05). Conclusions: According to the results, the mean rate of microalbuminuria in reflux decreased with the increased degree of reflux. Due to the changes in microalbuminuria compared to the severity of urinary reflux, this method cannot be used to determine the severity of reflux, which it could be considered an influential factor and a method used for the early diagnosis and follow-up of patients and preventing final kidney damage and renal failure.
Randomized Trial of a Supportive Psychotherapy for Parents of Adolescents and Young Adults With Hematologic Malignancies
Authors: Koehler Michael , Hoppe Susanne , Kropf Siegfried , Lux Anke , Bartsch Rainer , Holzner Bernhard , Krauter Juergen , Florschütz Axel , Jentsch-Ullrich Kathleen , Frommer Joerg , Flechtner Hans-Henning , Fischer Thomas
Published: April 2022

Background: Cancer regularly disrupts health and developmental trajectories in adolescents and young adults (AYAs). Parents have been shown to have a substantial impact on the health and cancer survivorship activities of AYA patients in the form of symptom management. However, no randomized controlled trial has evaluated a coping support intervention (CSI) program for parents of AYAs with cancer aged 18 to 40 years. Patients and Methods: From November 30, 2012, to August 29, 2016, parents of AYAs with hematologic malignancies were randomized in a phase III controlled trial (1:1 ratio, stratified sampling) to either the research-based CSI AYA-Parents group (CSI group; n=82) or the standard care (SC) group (n=70). CSI consisted of 5 sessions to achieve the enhancement of parental adaptive coping as the primary outcome (per the adaptive coping scale of the 28-item Brief COPE, a validated multidimensional self-assessment-questionnaire recommended for clinical cancer research). Measures of adaptive coping, depression, and mental health were collected at pre-CSI (measurement date T1), at the end of the intervention sessions (measurement date T2), and at follow-up (3 months). We calculated mean change scores in outcomes and estimated intervention effect sizes (Cohen’s d) for changes from T1 to T2/T3, with 0.2 indicating a small effect, 0.5 a medium effect, and 0.8 a large effect. All statistical tests were 2-sided. Results: In the intention-to-treat analysis, the CSI group significantly improved their adaptive coping compared with the SC group (95% CI, 0.30–2.54; P=.013; d=0.405), whereas adaptive coping in the SC group deteriorated. The CSI group also experienced a significant decrease in depressive symptoms and improved mental health with clinical significance (95% CI, –1.98 to –0.30; P=.008; d=0.433, and 95% CI, –0.19 to 3.97; P=.074; d=0.292, respectively). Sensitivity analyses confirmed the robustness of the main intention-to-treat analysis. Conclusions: CSI improved effectively adaptive coping and depression in parents of AYAs with hematologic malignancies. It may represent a novel family-based approach in AYA oncology care.
Response of Leptomeningeal Metastasis of Breast Cancer With a HER2/neu Activating Variant to Tucatinib: A Case Report
Authors: Yan Fengting , Rinn Kristine J. , Kullnat Jonathon A. , Wu Aimee Y. , Ennett Maura D. , Scott Elizabeth L. , Kaplan Henry G.
Published: April 2022

Metastatic breast cancer demonstratesHER2/neuamplification approximately 15% of the time. However,HER2mutations, which often stimulate tumor growth, occur in only 3% to 5% of patients, and are seen more frequently in metastatic versus primary tumors. They are more frequent in lobular carcinoma, including triple-negative lobular cancer. Many of these variants are resistant to trastuzumab and lapatinib. However, neratinib can be efficacious, and recent data suggest that antibody–drug conjugates (ADCs) such as ado-trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan may also be helpful. Laboratory and clinical data raise the possibility that simultaneous treatment with ADCs plus neratinib may be even more efficacious. Tucatinib, which has demonstrated significant activity in the central nervous system, has also been shown in vitro to be active against a number of theseHER2variants. This report describes a patient with metastatic estrogen receptor–positive,HER2-nonamplified breast cancer with an activatingHER2mutation whose tumor became resistant to neratinib as well as capecitabine, but whose subsequent leptomeningeal disease had a dramatically successful response to tucatinib plus capecitabine. As the frequency ofHER2mutations increases during the evolution of metastatic breast cancer, it is important to obtain genomic evaluation on these tumors with either repeat tissue or liquid biopsy as they progress over time.
Approaches for improving performance of a national power sector: a Ghana exploration
Authors:   , Abdul-Ganiyu Abudu
Published: April 2022

This research aims to explore approaches for improving the performance of a national power sector, focusing on Ghana. This research topic is particularly important because the power sector must perform well to satisfy a constantly rising demand for any nation, particularly for an African country, like Ghana. A multilevel-concurrent triangulation design within the mixed-method paradigm forms the core of the methodology for this research. Three broad approaches have been explored. The first approach is efficiency modelling and evaluation based on Data Envelopment Analysis (DEA). The second applies international benchmarking (IB) to compare the performance of the power sector across a set of countries, including Ghana. Delphi approach is the third, which generates collective perspectives from experts in this sector in Ghana. The three approaches are integrated based on their findings and analysis to provide further insights for performance improvement of the sector. The DEA approach identifies the relatively best and least performed decision-making units (DMUs) in the sector over the years to facilitate internal learning. The IB approach identifies the best performing country or countries based on key performance indicators (KPIs) and reveals the best practices implemented in these best performing countries. The independence of the power sector institutions, long-term planning, and effective management have been reasons for the sector’s success among the benchmarking countries. The experts in Ghana confirmed that technical weaknesses have resulted in frequent interruptions in the power sector in Ghana, leading to high transmission and distribution (T&D) losses. The study also confirmed that the lack of investment and inefficient management of resources, and limited resources were the main problems in Ghana over the years. The integration of the findings of the three approaches provided significant insights for improving efficiency in the T&D subsectors, improving the regulatory and institutional framework, and improving performance of the general KPIs in the power sector. The study contributes to the performance improvement of power sectors in developing nations as well as the performance management literature. The study concludes that different performance approaches can be implemented to improve the efficiency and effective management of the power sector. The study identifies relative efficiencies for iii internal learning, effective management of power sector institutions, and the enforcement of power sector regulations as the ways forward.
Evolution of binding preferences among whole-genome duplicated transcription factors
Authors: Gera Tamar , Jonas Felix , More Roye , Barkai Naama
Published: April 2022

Throughout evolution, new transcription factors (TFs) emerge by gene duplication, promoting growth and rewiring of transcriptional networks. How TF duplicates diverge was studied in a few cases only. To provide a genome-scale view, we considered the set of budding yeast TFs classified as whole-genome duplication (WGD)-retained paralogs (~35% of all specific TFs). Using high-resolution profiling, we find that ~60% of paralogs evolved differential binding preferences. We show that this divergence results primarily from variations outside the DNA-binding domains (DBDs), while DBD preferences remain largely conserved. Analysis of non-WGD orthologs revealed uneven splitting of ancestral preferences between duplicates, and the preferential acquiring of new targets by the least conserved paralog (biased neo/sub-functionalization). Interactions between paralogs were rare, and, when present, occurred through weak competition for DNA-binding or dependency between dimer-forming paralogs. We discuss the implications of our findings for the evolutionary design of transcriptional networks.
The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast
Authors: Yu Houqing , Kamber Roarke A , Denic Vladimir
Published: April 2022

Autophagy receptor (or adaptor) proteins facilitate lysosomal destruction of various organelles in response to cellular stress, including nutrient deprivation. To what extent membrane-resident autophagy receptors also respond to organelle-restricted cues to induce selective autophagy remains poorly understood. We find that latent activation of the yeast pexophagy receptor Atg36 by the casein kinase Hrr25 in rich media is repressed by the ATPase activity of Pex1/6, the catalytic subunits of the exportomer AAA+ transmembrane complex enabling protein import into peroxisomes. Quantitative proteomics of purified Pex3, an obligate Atg36 coreceptor, support a model in which the exportomer tail anchored to the peroxisome membrane represses Atg36 phosphorylation on Pex3 without assistance from additional membrane factors. Indeed, we reconstitute inhibition of Atg36 phosphorylation in vitro using soluble Pex1/6 and define an N-terminal unstructured region of Atg36 that enables regulation by binding to Pex1. Our findings uncover a mechanism by which a compartment-specific AAA+ complex mediating organelle biogenesis and protein quality control staves off induction of selective autophagy.
Evaluation of cultivated land quality using attention mechanism-back propagation neural network
Authors: Liu Yulin , Li Jiaolong , Liu Chuang , Wei Jiangshu
Published: April 2022

Cultivated land quality is related to the quality and safety of agricultural products and to ecological safety. Therefore, reasonably evaluating the quality of land, which is helpful in identifying its benefits, is crucial. However, most studies have used traditional methods to estimate cultivated land quality, and there is little research on using deep learning for this purpose. Using Ya’an cultivated land as the research object, this study constructs an evaluation system for cultivated land quality based on seven aspects, including soil organic matter and soil texture. An attention mechanism (AM) is introduced into a back propagation (BP) neural network model. Therefore, an AM-BP neural network that is suitable for Ya’an cultivated land is designed. The sample is divided into training and test sets by a ratio of 7:3. We can output the evaluation results of cultivated land quality through experiments. Furthermore, they can be visualized through a pie chart. The experimental results indicate that the model effect of the AM-BP neural network is better than that of the BP neural network. That is, the mean square error is reduced by approximately 0.0019 and the determination coefficient is increased by approximately 0.005. In addition, this study obtains better results via the ensemble model. The quality of cultivated land in Yucheng District is generally good, i.e.,mostly third and fourth grades. It conforms to the normal distribution. Lastly, the method has certain to evaluate cultivated land quality, providing a reference for future cultivated land quality evaluation.
The effect of the COVID-19 pandemic on health care workers’ anxiety levels: a meta-analysis
Authors: Zhang Lunbo , Yan Ming , Takashima Kaito , Guo Wenru , Yamada Yuki
Published: April 2022

Background

The COVID-19 pandemic has been declared a public health emergency of international concern, causing excessive anxiety among health care workers. Additionally, publication bias and low-quality publications have become widespread, which can result in the dissemination of unreliable information. A meta-analysis was performed for this study with the following two aims: (1) to examine the prevalence of anxiety among health care workers and determine whether it has increased owing to the COVID-19 pandemic and (2) to investigate whether there has been an increase in publication bias.

Methods

All relevant studies published between 2015 and 2020 were searched in electronic databases (namely Web of Science, PubMed, Embase, PsycInfo, PsyArXiv, and medRxiv). The heterogeneity of the studies was assessed using the I2 statistic. The effect size (prevalence rate of anxiety) and 95% CI for each study were also calculated. We used moderator analysis to test for the effect of the COVID-19 pandemic on health care workers’ anxiety levels and to detect publication bias in COVID-19 studies. We assessed publication bias using funnel plots and Egger’s regression.

Results

A total of 122 studies with 118,025 participants met the inclusion criteria. Eighty-eight articles (75,066 participants) were related to COVID-19, 13 articles (9,222 participants) were unrelated to COVID-19 (i.e., articles related to other outbreaks, which were excluded), and 21 preprints (33,737 participants) were related to COVID-19. The pooled meta-analysis prevalence was 33.6% (95% CI [30.5−36.8]; 95% PI [6.5−76.3]). Moderator analysis revealed no significant differences between articles related to COVID-19 and those unrelated to COVID-19 (p = 0.824). Moreover, no significant differences were found between articles and preprints related to COVID-19 (p = 0.843). Significant heterogeneity was observed in each subgroup. An Egger’s test revealed publication bias in both articles and preprints related to COVID-19 (p < 0.001).

Conclusions

Determining whether the anxiety state of health care workers is altered by the COVID-19 pandemic is currently difficult. However, there is evidence that their anxiety levels may always be high, which suggests that more attention should be paid to their mental health. Furthermore, we found a substantial publication bias; however, the quality of the studies was relatively stable and reliable.
Los géneros musicales en las músicas populares urbanas y su dimensión temporal: estado de la cuestión y propuestas para su análisis
Authors:   Universidad Complutense de Madrid / Universidad Internacional de Valencia, Fellone Ugo
Published: April 2022

El estudio de la dimensión temporal de los géneros musicales es uno de los aspectos menos trabajados de los estudios sobre músicas populares urbanas. Más allá de puntuales referencias al carácter dinámico de los géneros musicales, pocos han sido los autores que han abordado de manera sistemática cómo se transforman estos a lo largo de su historia. En este artículo se realizará una revisión crítica de los principales planteamientos realizados al respecto, formulados por Franco Fabbri, Fabian Holt, Jennifer C. Lena y David Brackett. Más allá del resumen de sus teorías, el propósito de este trabajo es reflexionar sobre los aspectos en común, las lagunas y las disensiones que nos plantean sus propuestas de cara a abordar esta problemática. Esto nos llevará a revisar algunos conceptos relevantes para abordar históricamente los géneros musicales, prestando especial atención a las ideas de convención y comunidad.
La exclusión de artistas mujeres en los festivales: políticas de género y relevamientos cuantitativos en el ámbito musical profesional de la Argentina (2017-2019)
Authors:   Universidad de Buenos Aires-IIGG/CONICET, Liska Mercedes
Published: April 2022

A finales del año 2017 diferentes artistas empezaron a expresar de manera pública ciertos malestares debido a la poca presencia de mujeres en las programaciones artísticas de determinados eventos musicales emblemáticos. En poco tiempo, esa desigualdad se convirtió en un reclamo colectivo que impulsó una serie de acciones por parte de músicas mujeres y personas no binarias tendientes a pensar las condiciones del trabajo en el ámbito musical desde las lógicas de discriminación de género que operan en diferentes aspectos de la actividad. Una de las acciones más relevantes fue la creación de un proyecto de ley de cupo femenino en festivales y otros eventos musicales. A partir de un análisis discursivo y comunicacional y un estudio de observación participante, el siguiente artículo presenta un relevamiento de los acontecimientos recientes ocurridos en torno a festivales musicales de la Argentina y el uso gravitante de estadísticas de la actividad musical como estrategia de visibilización que repercutió de modo contundente en los medios de comunicación. Dicho trabajo forma parte de una investigación más extensa sobre las maneras específicas a través de las cuales se manifiestan desigualdades de género en la industria de la música argentina.
El estatuto de la afectividad en la música en potencia de Tomás Lefever
Authors:   Pontificia Universidad Católica de Valparaíso, Muñoz Farida Graciela
Published: April 2022

El artículo se ocupa de la música en potencia acuñada por Tomás Lefever, compositor, ensayista y poeta, cuya obra ha atravesado aéreamente los recursos lógicos de la música, trasuntando su hegemonía en un dinamismo de lo sensible. Revisaremos, en lo que sigue, un índice problemático de origen filosófico que promueve en Lefever el desarrollo de un pensamiento de matriz antagónica o contradictoria. Dicho proceso irá de la mano de su invención musical, en ella reconoceremos que la afectividad se plantea como uno de sus constituyentes fundamentales a través del cual instala su cuestionamiento a las determinaciones lógicas que circunscriben la partitura, vulnerando su trayectoria teleológica. En aras de un acercamiento al pensamiento cuasi inédito de Tomás Lefever, abordaremos la espontaneidad y la potencia como elementos que expresan dos caracteres de la afectividad. Finalmente, veremos que la invención lefeveriana encuentra en esta última tanto un principio constitutivo fundamental de la invención musical, como un sostén de las elaboraciones y derivas vitales.
Expression of PD-L1 in Urothelial Carcinoma and its Association with Clinicopathological Parameters
Authors: Anand Gurupriya , Kaur Harjot , Bhasin Tejinder Singh
Published: April 2022

Introduction: Urothelial cancer poses a substantial medical and public health challenge in most parts of the world. Programmed Death Ligand 1 (PD-L1) is a cell surface glycoprotein that plays an important role in the suppression of cellular immune responses to tumour and is now emerging as a new target for immunotherapy. Aim: To examine PD-L1 expression in urothelial carcinoma and its relationship with various clinicopathological parameters. Materials and Methods: A retrospective analysis study was conducted on 50 cases of Urothelial Carcinomas diagnosed in Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India from January 2016 to January 2019. Detailed clinical data of the patients’ was collected and the analysis was undertaken between February 2019 and April 2019. Tissues were formalin fixed, paraffin embedded and were studied for histopathological grading after staining with haematoxylin and eosin. All cases were subjected to immunohistochemistry for PD-L1 expression. Chi-square test was used to assess the relationship between PD-L1 positivity and various clinicopathological parameters. A p-value <0.05 was considered as statistically significant. Results: A total of of 50 cases were included and 54% (27 cases out of total 50) were low grade cases. The maximum incidence was seen in 5th-7th decade of life with male preponderance. 27 cases out of the total 50 were low grade cases while the rest 46% (23 cases) were high grade. The PD-L1 positivity was observed in 19 cases (38%). The PD-L1 expression was significantly associated with high grade of tumour, increase in size of tumour and lamina propria invasion. Age, gender and muscle invasion however had no association with PD-L1 expression. Conclusion: The present study concluded that expression of PDL1 was significantly correlated with poorer clinicopathological variables including increasing size, higher grade and lamina propria invasion. PD-L1 positivity is therefore a bad prognostic marker
РЕАНИМАЦИЯ ОРБИТАЛЬНОЙ СТАНЦИИ «САЛЮТ-7», "Земля и Вселенная"
Authors: Соловьёв В.А. , Цыганков О.С.
Published: April 2022

Статья освещает события и факты отечественной космонавтики, произошедшие в 1984 г., связанные с восстановлением вышедшей из строя резервной топливной магистрали объединенной двигательной установки орбитальной станции «Салют 7»1. Работы, выполненные экипажем третьей основной экспедиции (Л.Д. Кизим, В.А. Соловьёв, О.Ю. Атьков) в открытом космосе, их наземная подготовка стала образцом в истории внекорабельной деятельности (ВКД, выходы космонавтов в открытый космос для проведения различных работ) и ее технического обеспечения, определили вектор развития внекорабельной деятельности на ближнюю и более отдаленную перспективу. Авторы – непосредственные участники реализации и подготовки работ, рассматривают события с дистанции 38 лет, но воспроизводят их как факты совсем недавнего прошлого.
МИКРОБИОЦЕНОЗ КИШЕЧНИКА У БОЛЬНЫХ ТУБЕРКУЛЕЗОМ С МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТЬЮ ВОЗБУДИТЕЛЯ С СИНДРОМОМ КИШЕЧНОЙ ДИСПЕПСИИ, ВОЗНИКШИМ В УСЛОВИЯХ ПРОТИВОТУБЕРКУЛЕЗНОЙ ТЕРАПИИ, "Вестник Центрального научно-исследовательского института туберкулеза
Authors: Холодов А.А. , Захарова Ю.В. , Отдушкина Л.Ю. , Галайда Н.М. , Пьянзова Т.В.
Published: April 2022

В статье определено влияние противотуберкулезной терапии, а также некоторых отдельных противотуберкулезных препаратов на формирование диспептического синдрома. Проведен анализ состояния микробиоценоза кишечника у 30 пациентов в процессе противотуберкулезной химиотерапии по IV режиму. Установлено, что в процессе противотуберкулезной химиотерапии у пациентов формировались нарушения со стороны микробиоценоза кишечника, характеризовавшиеся снижением титров его облигатных представителей и увеличением качественно-количественного состава транзиторных и условно-патогенных микроорганизмов. Значимое влияние на формирование диспептического синдрома оказывал прием парааминосалициловой кислоты, протионамида, пиразинамида.