bluuebunny/crossref_metadata_2025 huggingface dataset:
Parecoxib and 5-Fluorouracil Synergistically Inhibit EMT and Subsequent Metastasis in Colorectal Cancer by Targeting PI3K/Akt/NF-κB Signaling
Authors: Chang Wan-Ling , Peng Jyun-Yu , Hong Chain-Lang , Li Pei-Ching , Lu Fung-Jou , Chen Ching-Hsein
Published: July 2024

Colorectal cancer is one of the most common causes of cancer mortality worldwide, and innovative drugs for the treatment of colorectal cancer are continually being developed. 5-Fluorouracil (5-FU) is a common clinical chemotherapeutic drug. Acquired resistance to 5-FU is a clinical challenge in colorectal cancer treatment. Parecoxib is a selective COX-2-specific inhibitor that was demonstrated to inhibit metastasis in colorectal cancers in our previous study. This study aimed to investigate the synergistic antimetastatic activities of parecoxib to 5-FU in human colorectal cancer cells and determine the underlying mechanisms. Parecoxib and 5-FU synergistically suppressed metastasis in colorectal cancer cells. Treatment with the parecoxib/5-FU combination induced an increase in E-cadherin and decrease in β-catenin expression. The parecoxib/5-FU combination inhibited MMP-9 activity, and the NF-κB pathway was suppressed as well. Mechanistic analysis denoted that the parecoxib/5-FU combination hindered the essential molecules of the PI3K/Akt route to obstruct metastatic colorectal cancer. Furthermore, the parecoxib/5-FU combination could inhibit reactive oxygen species. Our work showed the antimetastatic capacity of the parecoxib/5-FU combination for treating colorectal cancers via the targeting of the PI3K/Akt/NF-κB pathway.
Relationship between Visual Attention Patterns and Subjective Evaluations in Housing Sales Information: A Study Using Eye-Tracking Technology
Authors: de-Juan-Ripoll Carla , Nolé María Luisa , Montañana Antoni , Llinares Carmen
Published: July 2024

Traditionally, studies analyzing consumer preferences in real estate have focused on measuring subjective user responses, neglecting associated physiological responses. This study investigates the relationship between visual attention patterns and subjective evaluations of home sales information. Eye-tracking technology was used to record two characteristics of 21 participants’ visual behavior while viewing stimuli containing information about home sales (First Fixation Time and Total Fixation Duration). Additionally, participants evaluated their level of satisfaction with nine dwelling characteristics based on a questionnaire adapted for this research (1, quality and finishes of the dwelling; 2, size of the dwelling; 3, dwelling floor level; 4, bright and outdoor orientation of the dwelling; 5, flexible layout; 6, peaceful atmosphere; 7, smart and secure character; 8, privacy; and 9, original and luxurious character). The results demonstrated significant correlations between fixation time on specific areas of the stimulus and subjective ratings of features such as size, quality, finishes, layout, and orientation of the homes. Furthermore, differences based on gender and participants’ architecture experience level were observed in visual behavior during image observation. These findings underscore the importance of visual design and presentation in home marketing, as visual attention can influence perceptions of home characteristics and, ultimately, purchase decisions.
Exclusive Review Papers in Catalytic Materials
Authors: Belver Carolina
Published: July 2024

Catalytic materials exist in several forms and can be prepared using different methodologies and protocols [...]
Inositol Restores Appropriate Steroidogenesis in PCOS Ovaries Both In Vitro and In Vivo Experimental Mouse Models
Authors: Fedeli Valeria , Unfer Vittorio , Dinicola Simona , Laganà Antonio Simone , Canipari Rita , Monti Noemi , Querqui Alessandro , Galante Emanuele , Laurenzi Gaia , Bizzarri Mariano
Published: July 2024

Androgen excess is a key feature of several clinical phenotypes of polycystic ovary syndrome (PCOS). However, the presence of FSH receptor (FSHR) and aromatase (CYP19A1) activity responses to physiological endocrine stimuli play a critical role in the pathogenesis of PCOS. Preliminary data suggest that myo-Inositol (myo-Ins) and D-Chiro-Inositol (D-Chiro-Ins) may reactivate CYP19A1 activity. We investigated the steroidogenic pathway of Theca (TCs) and Granulosa cells (GCs) in an experimental model of murine PCOS induced in CD1 mice exposed for 10 weeks to a continuous light regimen. The effect of treatment with different combinations of myo-Ins and D-Chiro-Ins on the expression of Fshr, androgenic, and estrogenic enzymes was analyzed by real-time PCR in isolated TCs and GCs and in ovaries isolated from healthy and PCOS mice. Myo-Ins and D-Chiro-Ins, at a ratio of 40:1 at pharmacological and physiological concentrations, positively modulate the steroidogenic activity of TCs and the expression of Cyp19a1 and Fshr in GCs. Moreover, in vivo, inositols (40:1 ratio) significantly increase Cyp19a1 and Fshr. These changes in gene expression are mirrored by modifications in hormone levels in the serum of treated animals. Myo-Ins and D-Chiro-Ins in the 40:1 formula efficiently rescued PCOS features by up-regulating aromatase and FSHR levels while down-regulating androgen excesses produced by TCs.
Validation of a Headspace Gas Chromatography with Flame Ionization Detection Method to Quantify Blood Alcohol Concentration (BAC) for Forensic Practice
Authors: Cerioni Alice , Mietti Gianmario , Cippitelli Marta , Ricchezze Giulia , Buratti Erika , Froldi Rino , Cingolani Mariano , Scendoni Roberto
Published: July 2024

Alcohol consumption is a major social and forensic issue. It is often the cause of road accidents, industrial accidents, suicides and other crimes. On account of this, it is of fundamental importance in forensic toxicology to correctly quantify blood alcohol concentration (BAC). In this work, a straightforward method for the quantification of ethanol from blood samples by means of headspace gas chromatography with flame ionization detection is presented and validated. For method validation linearity, limit of detection (LOD), lower limit of quantification (LLOQ), accuracy, precision (% CV) and interference studies were carried out. All the validation conditions were satisfied according to the acceptance criteria. Proof of applicability was performed on 50 real blood samples, showing that the method was effective.
Continuous Infusion of Dexmedetomidine for Maintenance of Sedation in an Aggressive Adolescent with Autism Spectrum Disorder in the Emergency Department
Authors: Cozzi Giorgio , Zago Alessandro , Poropat Federico , Rabach Ingrid , Barbi Egidio , Amaddeo Alessandro
Published: July 2024

Background: The treatment of aggressive behavior and agitation in pediatric patients with autism spectrum disorder (ASD) in the emergency department is topical and challenging. Case Presentation: We described an adolescent with autism spectrum disorder treated ten times in the pediatric emergency department for severe episodes of aggressiveness and agitation. After resolving the acute phase of these behavioural crises, sedation was maintained with a continuous infusion of dexmedetomidine to prevent the resurgence of agitation and to organize discharge properly, considering the family’s needs. The continuous infusion of dexmedetomidine allowed the patient to remain asleep most of the time during his stay at the emergency department. No adverse events were recorded. Conclusions: The continuous infusion of dexmedetomidine could represent a safe and valuable tool to facilitate the permanence of the patient in the PED.
Nasal High-Frequency Oscillatory Ventilation Use in Romanian Neonatal Intensive Care Units—The Results of a Recent Survey
Authors: Ognean Maria Livia , Bivoleanu Anca , Cucerea Manuela , Galiș Radu , Roșca Ioana , Surdu Monica , Stoicescu Silvia-Maria , Ramanathan Rangasamy
Published: July 2024

Background: Nasal high-frequency oscillatory ventilation (nHFOV) has emerged as an effective initial and rescue noninvasive respiratory support mode for preterm infants with respiratory distress syndrome (RDS); however, little is known about nHFOV use in Romanian neonatal intensive care units (NICUs). Objectives: We aimed to identify the usage extent and clinical application of nHFOV in Romania. Methods: A structured web-based questionnaire was designed to find the rate of nHFOV use and knowledge of this new method of noninvasive respiratory support in Romanian level III NICUs. Using multiple-choice, open-ended, and yes/no questions, we collected information on the NICU’s size, noninvasive respiratory support modes used, nHFOV use, indications, settings, nasal interfaces, secondary effects, and equipment used. Descriptive statistics and comparisons were performed using IBM SPSS Statistics 26.0. Results: A total of 21/23 (91.3%) leaders from level III NICUs (median [IQR] number of beds of 10 [10–17.5]) responded to the survey. The most frequently used noninvasive ventilation modes were CPAP mode on mechanical ventilators (76.2%), followed by NIPPV (76.2%); heated, humidified high-flow nasal cannula (HHHFNC) (61.9%); and nHFOV (11/21 units; 52.4%). A total of 5/11 units reported frequent nHFOV use (in two or more newborns/month) in both term and preterm infants. The main indications reported for nHFOV use were CPAP failure (90.9%), hypercapnia (81.8%), and bronchopulmonary dysplasia (72.7%). Face/nasal masks and short binasal prongs are the most commonly used nasal interfaces (90.9% and 72.7%, respectively). Air leaks at the interface level (90.9%), thick secretions (81.8%), and airway obstruction (63.6%) were the most frequently mentioned adverse effects of nHFOV. Only three of the NICUs had a written protocol for nHFOV use. Most units not yet using nHFOV cited lack of equipment, experience, training, or insufficient information and evidence for the clinical use and outcome of nHFOV use in neonates as the main reasons for not implementing this noninvasive respiratory mode. Conclusions: Our survey showed that nHFOV is already used in more than half of the Romanian level III NICUs to support term and preterm infants with respiratory distress despite a lack of consensus regarding indications and settings during nHFOV.
Effects of Intra-Articular Triamcinolone Injection on Adhesive Capsulitis after Breast Cancer Surgery
Authors: Kim Sungwon , Kim Sunwoo , Do Jong Geol , Hwang Ji Hye
Published: July 2024

Purpose: To investigate the effects of intra-articular glenohumeral joint triamcinolone injection in treating secondary adhesive capsulitis after breast cancer surgery. Methods: This study prospectively enrolled 37 participants, including 22 in the breast cancer surgery group and 15 in the idiopathic group. All participants received intra-articular glenohumeral joint triamcinolone injection in the affected shoulder joint. The clinical outcomes included the Shoulder Pain and Disability Index (SPADI), passive range of motion (PROM), and pain intensity on the Numeric Rating Scale (NRS), which were evaluated before the intervention and 1, 3, and 6 months after. The primary outcome of this study was the mean difference in the total SPADI from baseline to 6 months after the intervention. Results: The mean differences in the total SPADI scores from baseline to 6 months after the intervention were 36.2 ± 16.4 and 47.9 ± 15.2 in the breast cancer surgery group and the idiopathic group, respectively. There was no significant difference between the two groups (p = 0.1495). However, the improvements in the SPADI pain subscale at the 3- and 6-month follow-up visits (−31.2 vs. −48.8, p = 0.042; −34.1 vs. −50.7, p = 0.0006) and the PROM of abduction at the 3-month follow-up (52.4 vs. 70.3, p = 0.0072) were inferior in the breast cancer surgery group compared to the idiopathic group. There were no adverse events in either group. Conclusion: Intra-articular triamcinolone injection is an effective and safe treatment option for adhesive capsulitis after breast cancer surgery; however, it has less effect than for idiopathic adhesive capsulitis.
High Prevalence of Myositis-Specific and Associated Antibodies in Patients with Pulmonary Hypertension
Authors: Tobal Rachid , Potjewijd Judith , van Doorn Daan , van Empel Vanessa , Damoiseaux Jan , van Paassen Pieter
Published: July 2024

Pulmonary hypertension (PH) is a serious condition linked to immune-system dysfunction. Myositis-specific/associated antibodies (MSAs/MAAs) play a role in idiopathic inflammatory myopathy (IIM) and interstitial lung disease (ILD), but their significance in PH remains unclear. We believe the presence of these antibodies may be underestimated. This study analyzed adult PH patients without pre-existing IIM for MSA/MAA prevalence using a line-blot assay. We compared PH patients with and without ILD signs to a cohort clinically suspected of IIM/ILD (n = 558). Our PH cohort (n = 121) showed a significantly higher prevalence of overall weak positive MSAs/MAAs and positive overlap syndrome-associated MAAs than the suspected IIM/ILD group (p < 0.001). Notably, MSAs/MAAs were found in PH patients both with and without ILD, though more prevalent in those with ILD. Anti-synthetase and anti-overlap syndrome antibodies were the most common. Our study is the first to systematically show a high MSA/MAA prevalence in PH without IIM presentation. This highlights the need to consider PH when diagnosing MSA/MAA-associated conditions. We recommend MSA/MAA screening for newly diagnosed PH, especially in those with ILD, for early detection and potential immunomodulatory treatment. Further research should explore the link between MSAs/MAAs and PH, and the value of monitoring patients with weak MSA/MAA positivity over time.
Research on Artificial-Intelligence-Assisted Medicine: A Survey on Medical Artificial Intelligence
Authors: Gou Fangfang , Liu Jun , Xiao Chunwen , Wu Jia
Published: July 2024

With the improvement of economic conditions and the increase in living standards, people’s attention in regard to health is also continuously increasing. They are beginning to place their hopes on machines, expecting artificial intelligence (AI) to provide a more humanized medical environment and personalized services, thus greatly expanding the supply and bridging the gap between resource supply and demand. With the development of IoT technology, the arrival of the 5G and 6G communication era, and the enhancement of computing capabilities in particular, the development and application of AI-assisted healthcare have been further promoted. Currently, research on and the application of artificial intelligence in the field of medical assistance are continuously deepening and expanding. AI holds immense economic value and has many potential applications in regard to medical institutions, patients, and healthcare professionals. It has the ability to enhance medical efficiency, reduce healthcare costs, improve the quality of healthcare services, and provide a more intelligent and humanized service experience for healthcare professionals and patients. This study elaborates on AI development history and development timelines in the medical field, types of AI technologies in healthcare informatics, the application of AI in the medical field, and opportunities and challenges of AI in the field of medicine. The combination of healthcare and artificial intelligence has a profound impact on human life, improving human health levels and quality of life and changing human lifestyles.
DLSW-YOLOv8n: A Novel Small Maritime Search and Rescue Object Detection Framework for UAV Images with Deformable Large Kernel Net
Authors: Fu Zhumu , Xiao Yuehao , Tao Fazhan , Si Pengju , Zhu Longlong
Published: July 2024

Unmanned aerial vehicle maritime search and rescue target detection is susceptible to external factors, which can seriously reduce detection accuracy. To address these challenges, the DLSW-YOLOv8n algorithm is proposed combining Deformable Large Kernel Net (DL-Net), SPD-Conv, and WIOU. Firstly, to refine the contextual understanding ability of the model, the DL-Net is integrated into the C2f module of the backbone network. Secondly, to enhance the small target characterization representation, a spatial-depth layer is used instead of pooling in the convolution module, and an additional detection head is integrated into the low-level feature map. The loss function is improved to enhance small target localization performance. Finally, a UAV maritime target detection dataset is employed to demonstrate the effectiveness of the proposed algorithm, whose results show that DLSW-YOLOv8n achieves a detection accuracy of 79.5%, which represents an improvement of 13.1% compared to YOLOv8n.
Storytelling in STEM Disciplines: At the Crossroads of Science and Humanities
Authors: Spagnolo Camilla , Bolondi Giorgio , Corni Federico , Drius Mita
Published: July 2024

The collected papers in this Special Issue make significant contributions to educational research by demonstrating the multifaceted benefits of integrating storytelling and narrative techniques into teaching practices across various disciplines [...]
Examining the Impact of a Behavior Modification Program on Disease Prevention Behaviors among Individuals at Risk of Diabetes: A Quasi-Experimental Investigation
Authors: Phudphad Thanatkorn , Teravecharoenchai Supat , Khemtong Panit , Suksatan Wanich
Published: July 2024

This study aimed to develop and test a behavior modification intervention to prevent type 2 diabetes (T2DM) among at-risk individuals. The primary goal was to compare diabetes prevention behaviors and fasting blood sugar levels between the intervention and comparison groups. This study utilizes a quasi-experimental design to develop a behavior modification intervention for preventing diabetes. It involves two groups, each with pre- and post-intervention assessments, comprising 60 at-risk individuals equally divided into intervention and comparison groups. The 8-week intervention includes components like risk assessment, dietary skill enhancement, exercise, stress management, and social media platforms (data recording training, follow-up visits, reminders, and visual aids). Data collection includes self-administered questionnaires and blood sugar level measurements. Statistical analysis involved paired t-tests for within-group comparisons and independent t-tests for between-group differences. The findings showed that the intervention group achieved significantly higher average scores in nutrition, exercise, and stress management, and had significantly lower average blood sugar levels compared to the comparison group. These results suggest that healthcare providers and policymakers should develop community health programs and public health policies that incorporate integrative care, leverage social media platforms, and foster collaboration with other health professionals to improve outcomes for individuals at risk of T2DM.
Research on Runoff Prediction Based on Time2Vec-TCN-Transformer Driven by Multi-Source Data
Authors: Liu Yang , Wang Yize , Liu Xuemei , Wang Xingzhi , Ren Zehong , Wu Songlin
Published: July 2024

Due to the frequent occurrence of extreme weather in recent years, accurate runoff prediction is crucial for the rational planning and management of water resources. Addressing the high uncertainty and multiple influencing factors in runoff prediction, this paper proposes a runoff prediction method driven by multi-source data. Based on multivariate observed data of runoff, water level, temperature, and precipitation, a Time2Vec-TCN-Transformer model is proposed for runoff prediction research and compared with LSTM, TCN, and TCN-Transformer models. The results show that the Time2Vec-TCN-Transformer model outperforms other models in metrics including MAE, RRMSE, MAPE, and NSE, demonstrating higher prediction accuracy and reliability. By effectively combining Time2Vec, TCN, and Transformer, the proposed model improves the MAPE for forecasting 1–4 days in the future by approximately 7% compared to the traditional LSTM model and 4% compared to the standalone TCN model, while maintaining NSE consistently between 0.9 and 1. This model can better capture the periodicity, long-term scale information, and relationships among multiple variables of runoff data, providing reliable predictive support for flood forecasting and water resources management.
Thumbnail-Preserving Encryption Technology Based on Digital Processing
Authors: Li Dan , Zhang Ziming , Dai Xu , Wang Erfu
Published: July 2024

In recent years, the security of cloud storage has become a topic attracting significant attention due to a series of features such as large storage space, high availability, and low cost. Although traditional plain text images can withstand external attacks, the usability of images is completely lost. In order to balance the usability and privacy of images, some scholars have proposed the thumbnail-preserving encryption (TPE) scheme. The ideal TPE algorithm can keep the same thumbnail before and after encryption, which reduces the time cost and strengthens the resistance to attacks, but the existing schemes cannot fulfill the above criteria. In this paper, we propose a new TPE scheme that combines bit-transform encryption and improved hierarchical encryption. By constructing a chaotic system, both encryption and decryption times are shortened, while the randomness of the selected cells is enhanced. In addition, the Hamming distance is introduced to classify and scramble the binary encryption units. The experimental results show that when the number of thumbnail chunks is 16 × 16, the encryption and decryption time decreases to 4 s, and the SSIM value after encryption is close to 1, which indicates that the thumbnail before and after satisfying the encryption basically remains the same, and when the number of chunks is gradually increased, the success rate of the face detection tends to be close to 0. In addition, as the number of experimental iterations increases, the encryption effect improves with an increasing ability to resist attacks.
Integrating Digital Technologies in Sustainability Accounting and Reporting: Perceptions of Professional Cloud Computing Users
Authors: Petcu Monica Aureliana , Sobolevschi-David Maria-Iulia , Curea Stefania Cristina
Published: July 2024

The configuration of economic development, through complexity, rhythm, and amplitude, imposed Industry 4.0 as a new industrial paradigm characterized by advanced digitalization and automation. Appropriate behavior of organizations from a sustainable perspective and the expansion of performance evaluations by considering economic–financial, social, and environmental aspects supposed the reconsideration of the role of accounting in reporting, advice on risk management, and determination of organizational policies. The application of digital technologies in sustainability accounting and reporting requires mapping the attributes of Industry 4.0 and the collection, processing, and reporting of financial and non-financial information. The purpose of this research consists of a correlative analysis of the impact of sustainable development constraints and Industry 4.0 on sustainability accounting and reporting. To collect information, we developed a semi-structured questionnaire, distributed to the members of The Romanian Chamber of Fiscal Consultants. The data have been processed using correlation and regression analysis. The odds of achieving a higher quality of information provided to stakeholders are greater for those interested in digital transformation, sustainable accounting and reporting digitization, while ensuring data protection and security. In the case of cloud computing users, the digitalization of sustainability accounting and reporting were identified as key factors in the process.
Dynamic Compressive Stress Relaxation Model of Tomato Fruit Based on Long Short-Term Memory Model
Authors: Ru Mengfei , Feng Qingchun , Sun Na , Li Yajun , Sun Jiahui , Li Jianxun , Zhao Chunjiang
Published: July 2024

Tomatoes are prone to mechanical damage due to improper gripping forces during automated harvest and postharvest processes. To reduce this damage, a dynamic viscoelastic model based on long short-term memory (LSTM) is proposed to fit the dynamic compression stress relaxation characteristics of the individual fruit. Furthermore, the classical stress relaxation models involved, the triple-element Maxwell and Caputo fractional derivative models, are compared with the LSTM model to validate its performance. Meanwhile, the LSTM and classical stress relaxation models are used to predict the stress relaxation characteristics of tomato fruit with different fruit sizes and compression positions. The results for the whole test dataset show that the LSTM model achieves a RMSE of 2.829×10−5 Mpa and a MAPE of 0.228%. It significantly outperforms the Caputo fractional derivative model by demonstrating a substantial enhancement with a 37% decrease in RMSE and a 36% reduction in MAPE. Further analysis of individual tomato fruit reveals the LSTM model’s performance, with the minimum RMSE recorded at the septum position being 3.438×10−5 Mpa, 31% higher than the maximum RMSE at the locule position. Similarly, the lowest MAPE at the septum stands at 0.375%, outperforming the highest MAPE at the locule position by a significant margin of 90%. Moreover, the LSTM model consistently reports the smallest discrepancies between the predicted and observed values compared to classical stress relaxation models. This accuracy suggests that the LSTM model could effectively supplant classical stress relaxation models for predicting stress relaxation changes in individual tomato fruit.
Preparation and Effect of CO2 Response Gel for Plugging Low-Permeability Reservoirs
Authors: Wang Huipeng , Yang Changhua , Zhang Yongwei , Wang Chen
Published: July 2024

In order to solve the problem of gas channeling during CO2 flooding in low-permeability reservoirs, a novel CO2 responsive gel channeling system was prepared by using carrageenan, branched polyethylene imide and ethylenediamine under laboratory conditions. Based on the Box–Behnken response surface design method, the optimal synthesis concentration of the system was 0.5 wt% carrageenan, 2.5 wt% branchized polyethylenimide and 6.5 wt% ethylenediamine. The micromorphology of the system before and after response was characterized by scanning electron microscopy. The rheology and dehydration rate were tested under different conditions. The channeling performance and enhanced oil recovery effect of the gel system were simulated by a core displacement experiment. The experimental results show that the internal structure of the system changes from a disordered, smooth and loosely separated lamellae structure to a more uniform, complete and orderly three-dimensional network structure after exposure to CO2. The viscosity of the system was similar to aqueous solution before contact with CO2 and showed viscoelastic solid properties after contact with CO2. The experiment employing dehydration rates at different temperatures showed that the internal structure of the gel would change at a high temperature, but the gel system had a certain self-healing ability. The results of the displacement experiment show that the plugging rate of the gel system is stable at 85.32% after CO2 contact, and the recovery rate is increased by 17.06%, which provides an important guide for the development of low-permeability reservoirs.
Ka mua, ka muri—When I Was and When I Am
Authors: Gillon Ashlea
Published: July 2024

Kia ora e hoa, wishing wellness and vitality, to you, dear friend. This piece is a window into the realities of being a fat Māori girl and woman. It offers insights into the sense making, intimacies, and intricacies of being a fat Māori girl, and now woman. This piece is whakapapa, the layering of genealogy, of thought, of realities, of experiences, of identities. It offers a glimpse into a time of whakapapa, of how I have made sense of my world in my many identities. Here, I share poems written throughout my research journey and my relationship navigating insider-research, being embedded in the research, being the research, and the ways in which I actualize Kaupapa Māori research. This piece opens with a karakia, a spiritual offering of safety, of welcome, and starts with the poem When I was, sharing moments and memories from ages 5 to 33. It then transitions to the poem When I am, a poem of potential, which connects back with the atua Hinenuitepō, a powerful ancestor and wahine deity, as well as her stories, transitions, and Kaupapa that she has shared with me, so that I may make sense of the world and this Kaupapa, the ways she has guided me on my journey. It then ends with a karakia, a spiritual offering of safety and cleansing, a farewell, to you e hoa.
Effectiveness of Treatment Approaches in COVID-19 Pneumonia: A Comparative Evaluation between a Specialized Center and Conventional Hospitals
Authors: Romero Pareja Rodolfo , Ruiz Grinspan Martín S. , Castro Arias María Lorena , García Hernández Raquel , Martín Sánchez Francisco Javier , Álvarez-Rodríguez Esther , Álvarez Rodríguez Virginia , Minguens Iria , Martínez Molina Ana María , Torres Santos-Olmo Rosario , Aranda Sixto , Torres Rodríguez Enrique , Gimeno Galindo Carmen , Thuissard-Vasallo Israel J , Marco Martínez Javier
Published: July 2024

Background: The early stages of the COVID-19 pandemic overwhelmed general hospitals in Spain. In response, a dedicated hospital for COVID-19 care, the Hospital de Emergencias Enfermera Isabel Zendal (HEEIZ), was established. This study aimed to compare clinical outcomes of COVID-19 patients treated at the specialized HEEIZ with those at conventional general hospitals (CGHs) in Madrid, Spain. Methods: The study was a prospective, observational cohort study including COVID-19 patients admitted to the HEEIZ and 14 CGHs (December 2020 to August 2021). Patients were assigned based on hospital preference. Clinical data were collected and analyzed using multivariate regression to assess primary and secondary outcomes, including hospital mortality, need of invasive mechanical ventilation (IMV), and pharmacological treatments. Results: The HEEIZ cohort (n = 2997) was younger and had lower Charlson comorbidity scores than the CGH cohort (n = 1526). Adjusted HEEIZ hospital mortality was not significantly higher compared with CGHs (OR: 1.274; 95% CI: 0.781–2.079; p = 0.332). Conclusions: During the study period, patients admitted to the HEEIZ showed no significant differences in clinical outcomes, compared with patients admitted at CGHs. These results might support the use of specialized centers in managing pandemic surges, allowing CGHs to handle other needs.
Nursing Attitudes Questionnaire: Testing the Psychometric Characteristics of the Italian Version (NAQ-IV)
Authors: Rubbi Ivan , Conte Luana , Pasquinelli Gianandrea , Ferri Paola , Vitale Elsa , Lupo Roberto , Cremonini Valeria
Published: July 2024

Introduction: The image of a nurse is a source of concern due to its impact on recruitment into the profession, political decisions about the profession, and how the image affects nursing practice. For these reasons, one of the long-term challenges is to assess and maintain a favorable public image that respects the utility and value of the nursing profession. Aim: This study aims to validate an instrument for assessing the image of the nurse as perceived by Italian citizens. Methods: A non-probabilistic sample of 564 people participated in the study between 2022 and 2023. Sociodemographic information of the Italian citizens was collected, and the instrument used to evaluate the perceived public image was the Nursing Attitudes Questionnaire (NAQ). The psychometric properties of the Italian version of the NAQ (NAQ-IV) were calculated using Cronbach’s alpha, item–total correlations, skewness, and kurtosis. Factor analysis was performed using principal axis factoring and the varimax rotation method. Results: Factor analysis revealed a four-factor model explaining more than 60.52% of the variance, with the largest variance explained by the “Role and Professionalism” factor (34.08%). The internal consistency calculation showed a Cronbach’s alpha of 0.89 for the scale and between 0.88 and 0.89 among the factors; all the items verified the item–total correlation and response variability criteria. Conclusions: The NAQ-IV could be a valid tool for assessing the perception of Italian citizens. However, further studies are recommended to evaluate the reliability of the instrument, especially in the evolving professional profile and social health welfare.
Plant Genetic Diversity Studies: Insights from DNA Marker Analyses
Authors: Bidyananda Nongthombam , Jamir Imlitoshi , Nowakowska Karolina , Varte Vanlalrinchhani , Vendrame Wagner A. , Devi Rajkumari Sanayaima , Nongdam Potshangbam
Published: July 2024

The plant adaptation response to a changing environment depends on the genetic diversity level it possesses. Genetic diversity and a thorough understanding of population indices are pivotal for decoding plant adaptation to dynamic environmental stressors. The development of polymerase chain reaction (PCR)-based molecular markers enables comprehensive population analyses and the precise detection of individuals and groups with unique genetic variations. Various molecular markers have been employed to assess genetic diversity, examine population structure, and delineate cluster patterns within and among populations. DNA markers revolutionize plant diversity studies by allowing detailed analyses of genetic variations, including economically significant trait-influencing genes. Despite their simplicity, they offer high reproducibility, ensuring accurate estimations of plant variation. Integrating multiple marker systems with advanced high-throughput sequencing techniques is poised to enhance the understanding and management of depleting plant genetic resources by providing a comprehensive picture of diversity at the genome-wide level. This review explores diverse molecular markers, elucidating their advantages and limitations, and highlights their impact on evaluating the genetic diversity and population structure of plants.
Blood-Count-Derived Inflammatory Markers as Predictors of Response to Biologics and Small-Molecule Inhibitors in Psoriasis: A Multicenter Study
Authors: Morariu Silviu-Horia , Cotoi Ovidiu Simion , Tiucă Oana Mirela , Baican Adrian , Gheucă-Solovăstru Laura , Decean Hana , Brihan Ilarie , Silaghi Katalin , Biro Viorica , Șerban-Pescar Diana , Măgureanu Ioana , Ambros Mircea , Ilcuș Roxana Ioana , Prodan Lavinia , Bălan Andreea Beatrix , Husariu Mădălina , Gugulus Dumitrita Lenuta , Stan Radu Alexandru , Voiculescu Vlad , Nicolescu Alin Codruț
Published: July 2024

Background: Psoriasis is an immune-mediated chronic disorder associated with various comorbidities. Even though biologics and small-molecule inhibitors are the mainstay treatment for moderate-to-severe psoriasis, there is no current consensus regarding which agent should be used for a specific type of patient. This paper aims to test the reliability of blood-count-derived inflammatory markers in assessing treatment response to biologics and small-molecule inhibitors in psoriasis. Material and Methods: Bio-naïve adult patients diagnosed with chronic plaque psoriasis fulfilling the inclusion criteria were enrolled. They were divided into study subgroups based on treatment of choice, and blood-count-derived inflammatory markers were analyzed at baseline, three-month, six-month, and at twelve-month visits. Results: A total of 240 patients were included. The highest number of patients underwent treatment with ixekizumab. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-monocyte ratio (PMR), monocyte-to-lymphocyte ratio (MLR), derived neutrophil-to-lymphocyte ratio (d-NLR), systemic inflammation response index (SIRI), systemic immune inflammation index (SII), and aggregate index of systemic inflammation (AISI) all varied significantly (p < 0.005) between the four visits. The psoriasis area severity index (PASI) score correlated with PLR, d-NLR, and SII, while the psoriasis scalp severity index (PSSI) score correlated with AISI and SIRI. More than half of patients reached the target goal of PASI90 at the six-month visit. A total of 77 patients were super-responders, with the highest number undergoing treatment with ixekizumab. Higher baseline values of d-NLR and SIRI are independent predictors of the super-responder status. Conclusions: Blood-count-derived inflammatory markers can serve as indicators of treatment response to biologics in psoriasis, while d-NLR and SIRI were independent predictors of super-responders in our study.
The Impact of Race/Ethnicity on Disparities in Utilization and Outcomes of Neuraxial Anesthesia for Hip and Femoral Shaft Fractures
Authors: Qian Daniel , Olumuyide Ezekiel , Keswani Aakash , Lin Hung-Mo , Ouyang Yuxia , DeMaria Samuel , Poeran Jashvant , Park Chang H. , Burnett Garrett W.
Published: July 2024

Background/Objectives: The use of neuraxial anesthesia versus general anesthesia for hip fracture surgery remains an active area of research, with recent studies demonstrating mixed findings supporting neuraxial over general anesthesia. The benefits of neuraxial anesthesia have been documented in associated surgeries, including total joint arthroplasty. However, racial disparities in the administration of neuraxial anesthesia have been identified in numerous procedures. We aimed to examine the association of race/ethnicity with neuraxial anesthesia use and the effect of neuraxial anesthesia on length of stay, non-home discharge, 30-day severe adverse events, and rates of readmission among patients undergoing isolated hip and femoral shaft fracture operations. Methods: The American College of Surgeons National Quality Improvement Program database was queried for isolated hip or femoral shaft fractures from 2015 to 2019. Stepwise logistic regression was performed to assess the relationship between race/ethnicity and neuraxial anesthesia use. Within each sex–race stratum, neuraxial anesthesia recipients were propensity-matched to general anesthesia recipients in a 1:2 ratio. Logistic regression and negative binomial regression were performed on the propensity-matched cohort. Results: A total of 12,004 neuraxial and 64,250 general anesthesia hip and femoral shaft fracture patients were identified. Compared to White patients, Black and Hispanic patients were between 0.64 and 0.61 times less likely to receive neuraxial anesthesia over general anesthesia, respectively (p < 0.05). 11,993 patients who received neuraxial anesthesia were propensity matched to 23,946 patients who received general anesthesia. Propensity-matched logistic regressions found that neuraxial anesthesia was associated with decreased length of stay, 30-day severe adverse events, and acute rehab/skilled nursing facility discharge for White patients (p < 0.05 for all), but only decreased length of stay in Black and Hispanic patients (p = 0.01 and p = 0.02, respectively). Conclusions: Notable disparities exist in the administration of neuraxial anesthesia for isolated hip and femoral shaft fracture patients. Hispanic and Black race/ethnicity in particular influences provision of neuraxial anesthesia. Further research is required to understand the degree of effect modification and root causes of regional anesthesia access and benefits for this high-volume patient population.
The Efficacy of Antibiotic-Loaded Calcium Sulfate Beads (Stimulan) in Patients with Hip Arthroplasty Infections
Authors: Dimofte Florentin , Dimofte Cristina , Ungurianu Sorin , Serban Cristina , Țocu George , Cârneciu Nicoleta , Filip Iulia , Bezman Laura , Ciuntu Bogdan Mihnea , Abdulan Irina Mihaela , Mihailov Raul , Necula Radu Dan , Sabou Florin Lucian , Firescu Dorel
Published: July 2024

Background: Given the increasing rate of infections following hip arthroplasty, one of the current options is the application of a biocomposite at the site of the infection. One of the products used is Stimulan, a completely resorbable calcium sulfate, designed to treat acute and chronic infections. This biocomposite has a controlled purity, is easy to mix with liquid, powder, and antibiotics, and can be applied directly to the site of infection, or it can be injected. Methods: We analyzed data from 76 patients, who were admitted to the County Clinical Hospital of Emergency “St. Apostol Andrei” in Galati during January 2017–September 2023, with a diagnosis of infection associated with hip arthroplasty. Results: In 69.73% of cases (52 patients), we decided to keep the implant in place. In this subgroup, Stimulan was applied in 26 cases (57.78%). Of these, 100% were cured—compared to the subgroup in which Stimulan was not applied, where this percentage was lower. All patients underwent chemical and mechanical toileting, and for 24 patients (20.27%), it was necessary to ablate the implant with or without the application of Stimulan, then reimplantation of the prosthesis. Conclusions: The patients with Stimulan had a longer average length of hospitalization, almost half of them required intervention in two periods, and a quarter required the implantation of spacers. However, the cure rate was higher, only in three people could we not control the infection, and there was no death. This study confirms the effectiveness of the treatment when using a biocomposite in addition to the classical treatment for both acute and chronic cases.
Heart Rate Variability Biofeedback Efficacy on Fatigue and Energy Levels in Fibromyalgia: A Secondary Analysis of RCT NCT0412183
Authors: Carta Mauro Giovanni , Cossu Giulia , Primavera Diego , Aviles Gonzalez Cesar Ivan , Testa Giorgia , Stocchino Serena , Finco Gabriele , Littera Maria Teresa , Deidda Maria Cristina , Lorrai Stefano , Madeddu Clelia , Nardi Antonio Egidio , Sancassiani Federica
Published: July 2024

Background: Fibromyalgia syndrome (FMs) is a chronic condition characterized by widespread musculoskeletal pain and a range of complex symptoms, with chronic fatigue being a central feature significantly impacting daily life. The aim of this study was to analyze the secondary outcomes, specifically those related to perceived energy and fatigue symptoms in a randomized controlled trial (RCT) assessing the efficacy of heart rate variability biofeedback (HRV-BF) as an adjunctive treatment for FMs. Methods: Sixty-four FMs patients were randomly assigned to either receive 10 HRV-BF training sessions alongside standard pharmacological therapy (experimental group) or standard therapy alone for 10 weeks (control group). For this secondary analysis, potential improvements in specific items were evaluated regarding perceived energy (Item 10 of the Short-Form Health Survey), the ability to walk and climb stairs (Item 7 and Item 11 of the Fibromyalgia Impact Questionnaire, respectively), and the impact of pain on movement ability (Item 17 of the Bodily and Emotional Perception of Pain). Results: The experimental group demonstrated an improvement in the perception of energy, the ability to walk, and the impact of pain on movement ability. However, the same improvement was not observed in the ability to climb stairs. Conclusions: Fatigue assessment has emerged as a crucial factor for evaluating treatment efficacy in FMs and related conditions linked to altered energy levels, such as bipolar depression, and can offer valuable insights for precisely guiding HRV-BF treatments. ClinicalTrials.gov with code: NCT04121832.
Settlement of Chilean Flat Oysters (Ostrea chilensis) on Ribbed Mussel Shell Collectors for Commercial Grow-Out: Towards Sustainable Management
Authors: Oyarzún Pablo A. , Hidalgo-Cabrera Almendra , Stam Gerrit , Estrada Juan Manuel , Ruiz-Tagle Gonzalo , Navarro Jorge M. , Toro Jorge E.
Published: July 2024

Ostrea chilensis (a flat oyster) is native to Chile and New Zealand. In Chile, this oyster has been cultured and harvested for at least 80 years. However, the culture of flat oysters has not developed like other aquaculture activities in Chile, mainly due to the inefficiency of the collectors (made of ribbed mussel shells) and the lack of spats produced. The objective of this study was to determine the capacity of spat collectors for the settlement of O. chilensis. For this purpose, field and laboratory experiments were carried out. Our results indicated that oyster larvae do not have a preference for either side of the shell (periostracum or nacreous) to settle on. However, after one year of growth in the field, juveniles were more abundant on the nacreous side of the shell (spat collector). Also, the oysters that settled on the nacreous side of the valve were larger. This was due to the fact that the periostracum had a greater number of epibionts, and they competed for space and resources with the settled oyster spats, causing a decrease in the abundance of oyster spats on that surface. Our findings raise the possibility that collectors could improve efficiency in the production of spats. Finally, we discuss the implications of these results for the Chilean oyster-farming industry.
Spatial Characteristics of Multidimensional Urban Vitality and Its Impact Mechanisms by the Built Environment
Authors: Jin Aibo , Ge Yunyu , Zhang Shiyang
Published: July 2024

Urban vitality, intricately connected to urban morphology, has long been a cornerstone of urban planning and design. The accelerated pace of urbanization has created abundant living and working spaces, but it has also brought about a series of issues such as traffic congestion, environmental pollution, insufficient public spaces, and uneven urban development, leading to a decline in urban vitality. The spatial distribution patterns of urban vitality and their influencing factors are diverse and vary across different cities, necessitating a multidimensional exploration of the relationship between urban vitality and the built environment. Utilizing the central urban area of Beijing as a case study, this research leverages multi-source urban spatial data to delineate the spatial characteristics of social, economic, cultural, and comprehensive vitality. Furthermore, a comprehensive set of built-environment indicators is developed across five dimensions to analyze their correlation with urban vitality. The results indicate: (1) There is a significant spatial clustering of various vitality types in Beijing, with a pronounced correlation between high-density population aggregation and vigorous economic activities. (2) Subdistricts exhibiting high social vitality display an “n”-shaped distribution around the Second Ring Road. In contrast, those with high economic vitality are concentrated along Chang’an Street and various district commercial centers. High cultural vitality subdistricts are distributed in a northwest–southeast trajectory from the Fourth Ring Road to the Second Ring Road, and subdistricts with high comprehensive vitality exhibit a concentric distribution radiating outwards from the center. (3) Social vitality is most closely related to comprehensive vitality, and the various vitality types in Beijing’s central urban area develop relatively evenly. (4) The built environment significantly affects all types of urban vitality. Factors such as floor area ratio, POI density, POI mixing degree, and intersection density are fundamental to enhancing urban vitality, whereas the greening rate somewhat inhibits it. (5) Future spatial planning should utilize the radiating effect of high-vitality subdistricts to optimize population distribution, enhance POI mixing, increase metro station density, and strengthen critical urban structures for synergistic economic and cultural development. This study provides a foundation and promotion strategies for optimizing the layout and enhancing vitality at the subdistrict scale within Beijing’s central urban area.