bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative analysis of dose calculation algorithms for CyberKnife-based stereotactic radiotherapy in lung cancer
Authors: Ge Xuanchu , Yang Mingshan , Li Tengxiang , Liu Tonghai , Gao Xiangyu , Qiu Qingtao , Yin Yong
Published: October 2023

Purpose

The accuracy of dose calculation is the prerequisite for CyberKnife (CK) to implement precise stereotactic body radiotherapy (SBRT). In this study, CK-MLC treatment planning for early-stage non-small cell lung cancer (NSCLC) were compared using finite-size pencil beam (FSPB) algorithm, FSPB with lateral scaling option (FSPB_LS) and Monte Carlo (MC) algorithms, respectively. We concentrated on the enhancement of accuracy with the FSPB_LS algorithm over the conventional FSPB algorithm and the dose consistency with the MC algorithm.

Methods

In this study, 54 cases of NSCLC were subdivided into central lung cancer (CLC, n=26) and ultra-central lung cancer (UCLC, n=28). For each patient, we used the FSPB algorithm to generate a treatment plan. Then the dose was recalculated using FSPB_LS and MC dose algorithms based on the plans computed using the FSPB algorithm. The resultant plans were assessed by calculating the mean value of pertinent comparative parameters, including PTV prescription isodose, conformity index (CI), homogeneity index (HI), and dose-volume statistics of organs at risk (OARs).

Results

In this study, most dose parameters of PTV and OARs demonstrated a trend of MC > FSPB_LS > FSPB. The FSPB_LS algorithm aligns better with the dose parameters of the target compared to the MC algorithm, which is particularly evident in UCLC. However, the FSPB algorithm significantly underestimated the does of the target. Regarding the OARs in CLC, differences in dose parameters were observed between FSPB and FSPB_LS for V10 of the contralateral lung, as well as between FSPB and MC for mean dose (Dmean) of the contralateral lung and maximum dose (Dmax) of the aorta, exhibiting statistical differences. There were no statistically significant differences observed between FSPB_LS and MC for the OARs. However, the average dose deviation between FSPB_LS and MC algorithms for OARs ranged from 2.79% to 11.93%. No significant dose differences were observed among the three algorithms in UCLC.

Conclusion

For CLC, the FSPB_LS algorithm exhibited good consistency with the MC algorithm in PTV and demonstrated a significant improvement in accuracy when compared to the traditional FSPB algorithm. However, the FSPB_LS algorithm and the MC algorithm showed a significant dose deviation in OARs of CLC. In the case of UCLC, FSPB_LS showed better consistency with the MC algorithm than observed in CLC. Notwithstanding, UCLC’s OARs were highly sensitive to radiation dose and could result in potentially serious adverse reactions. Consequently, it is advisable to use the MC algorithm for dose calculation in both CLC and UCLC, while the application of FSPB_LS algorithm should be carefully considered.
Barriers to healthcare access in patients with chronic pain or potential migraine in Japan: a cross-sectional internet survey
Authors: Karasawa Yusuke , Yamaguchi Keisuke , Nakano Shogo , Nozawa Kazutaka , Iseki Masako
Published: October 2023

Purpose

Chronic pain and migraines often go untreated despite patient- and economic-related burdens (e.g., impaired quality of life and productivity). Understanding the reasons for non-treatment is important to enable interventions aimed at improving care-seeking behaviors. However, reports on disease-specific justifications for nontreatment in Japan are limited. We aimed to determine the barriers to healthcare access in untreated patients with chronic pain or migraines.

Patients and methods

This was a non-interventional, cross-sectional, internet questionnaire survey of patients with chronic pain or migraines. The primary endpoint was to identify the reasons for untreated chronic pain or migraines. Secondary endpoints included factors associated with healthcare access, including patient background, patient-reported outcomes, and awareness of generic or authorized generic drugs (AG).

Results

We surveyed 1,089 patients with chronic pain [605 (55.6%) untreated] and 932 patients with migraines [695 (74.6%) untreated] in 2021. The main reasons for not seeking treatment for chronic pain was “my pain is tolerable” and for migraine, “I can manage my pain with over-the-counter drugs.” Background factors significantly associated with untreated chronic pain were younger age, less time required to access the nearest medical institution, less pain, higher activities of daily living (ADL) scores, and lower awareness of generic drugs and AG. Among patients with migraine, notable characteristics included being female, having shorter travel times to the nearest medical facility, residing in municipalities with populations under 50,000, experiencing moderate to severe pain, having higher ADL scores, and displaying lower awareness of AG. The AG awareness rate was 2-fold higher in treated patients than in untreated patients.

Conclusion

Educating patients regarding the risks associated with pain and its underlying causes, availability of inexpensive treatment options, and location of appropriate treatment facilities may increase treatment rates.
Effect of Astragaloside IV on improving cardiac function in rats with heart failure: a preclinical systematic review and meta-analysis
Authors: Zhang Zhiyuan , Zhang Muxin , Xu Yongkai , Lu Mengkai , Zhang Lei , Li Chao
Published: October 2023

Background: Astragaloside IV (ASIV) is the primary pharmacologically active compound found in Astragalus propinquus Schischkin, which has potential protective effects on cardiac function. However, there are almost no systematic evaluations of ASIV for the treatment of heart failure (HF).

Methods: Preclinical studies published before 27 December 2022, were retrieved from PubMed, Web of Science, MEDLINE, SinoMed, Chinese National Knowledge Infrastructure (CNKI), VIP information database, and Wanfang Data information site. The quality of included research was evaluated using SYRCLE’s RoB tool. Review Manager 5.4.1 was used to perform meta-analyses of the cardiac function parameters and other indicators. Regression analysis was conducted to observe the dose-efficacy relationship.

Results: Nineteen studies involving 489 animals were included. Results indicated that compared with the control group, ASIV could enhance cardiac function indicators, including left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular pressure change rate (±dp/dtmax), left ventricular end-diastolic pressure (LVEDP), left ventricular systolic pressure (LVSP), heart weight/body weight (HW/BW) and left ventricular weight/body weight (LVW/BW). Furthermore, the regression analysis showed that the treatment of HF with ASIV was dose-dependent.

Conclusion: Findings suggest that ASIV can inhibit cardiac hypertrophy by reducing cardiac preload and afterload, thereby protecting cardiac function.
Effects of different grassland utilization methods on the germinable soil seed bank of the Hulunbuir meadow steppe
Authors: Yan Ruirui , Yu Tianqi , Liu Hongmei , Lv Shijie , Chen Baorui , Wu Yanling , Que Guoping , Wei Zhijun , Xu Lijun , Zhu Xiaoyu , Yang Guixia , Xin Xiaoping
Published: October 2023

Seed banks are crucial regenerative resources for aboveground vegetation. The pattern of their changes holds immense significance in understanding alterations in the belowground seed bank. This understanding is pivotal for uncovering both short-term and long-term shifts in plant communities. Additionally, it contributes to the restoration of grassland ecosystems. To better protect grassland biodiversity and provide a theoretical basis for the restoration of degraded grasslands, in this study, the germination characteristics of soil seed banks in free-grazed, enclosed and mown areas were compared, and the results were combined with those of previous studies for a comprehensive analysis. The density of soil seed bank and perennial forage soil seed bank were significantly affected by different grassland utilization and soil depths. Grazing and enclosure grassland utilization methods increased the content of the soil seed bank, and mowing reduced the content of the seed bank. The soil seed bank density of perennial grasses accounted for the highest proportion under grazing, followed by mowing, and its lowest proportion was observed in the enclosures. Grazing not only facilitated the germination of the perennial grass seed bank but also substantially augmented its content. Mowing inhibited the germination of the upper growth grasses seed bank, which was particularly significant in the 0-2 cm soil layer under grazing. The content of the upper growth grasses seed bank affected the total seed bank to a certain extent, mainly in the 5-10 cm layer. The general correlations among the perennial grasses, upper growth grasses and soil germination seed bank resulted in 84.58% information extraction, and this information has practical significance for grassland ecological restoration.
Deep learning-empowered crop breeding: intelligent, efficient and promising
Authors: Wang Xiaoding , Zeng Haitao , Lin Limei , Huang Yanze , Lin Hui , Que Youxiong
Published: October 2023

Crop breeding is one of the main approaches to increase crop yield and improve crop quality. However, the breeding process faces challenges such as complex data, difficulties in data acquisition, and low prediction accuracy, resulting in low breeding efficiency and long cycle. Deep learning-based crop breeding is a strategy that applies deep learning techniques to improve and optimize the breeding process, leading to accelerated crop improvement, enhanced breeding efficiency, and the development of higher-yielding, more adaptive, and disease-resistant varieties for agricultural production. This perspective briefly discusses the mechanisms, key applications, and impact of deep learning in crop breeding. We also highlight the current challenges associated with this topic and provide insights into its future application prospects.
MdSWEET23, a sucrose transporter from apple (Malus × domestica Borkh.), influences sugar metabolism and enhances cold tolerance in tomato
Authors: Nie Peixian , Wang Laiping , Li Miao , Lyu Deguo , Qin Sijun , Xue Xiaomin
Published: October 2023

Photosynthetic products in most fleshy fruits are unloaded via the apoplasmic pathway. Sugar transporters play an important role in the apoplasmic unloading pathway and are involved in sugar transport for fruit development. The MdSWEET23, cloned from ‘‘Hanfu’’ apple (Malus × domestica Borkh.) fruits, belongs to Clade III of the SWEET family. Subcellular localization revealed that MdSWEET23 is localized on the plasma membrane. β-glucuronidase activity assays showed that MdSWEET23 was primarily expressed in the sepal and carpel vascular bundle of apple fruits. Heterologous expression assays in yeast showed that MdSWEET23 functions in sucrose transport. The overexpression of MdSWEET23 in the ‘‘Orin” calli increased the soluble sugar content. The silencing of MdSWEET23 significantly reduced the contents of sucrose and sorbitol in apple fruits. Ectopic overexpression of MdSWEET23 in tomato altered sugar metabolism and distribution in leaves and fruits, causing a reduction in photosynthetic rates and plant height, enhanced cold stress tolerance, and increased the content of sucrose, fructose, and glucose in breaking color fruits, but did not increase sugar sink potency of tomato fruits.
An investigation of age dependency in Dutch and Chinese values for EQ-5D-Y
Authors: Essers Brigitte , Wang Pei , Stolk Elly , Jonker Marcel F. , Evers Silvia , Joore Manuela , Dirksen Carmen
Published: October 2023

Aims

The primary aim was to explore the age dependency of health state values derived via trade-offs between health-related quality of life (HRQoL) and life years in a discrete choice experiment (DCE). The secondary aim was to explore if people weigh life years and HRQoL differently for children, adolescents, adults, and older adults.

Methods

Participants from the general population of the Netherlands and China first completed a series of choice tasks offering choices between two EQ-5D-Y states with a given lifespan. The choice model captured the value of a year in full health, disutility determined by EQ-5D-Y, and a discount rate. Next, they received a slightly different choice task, offering choices between two lives that differed in HRQoL and life expectancy but produced the same number of quality-adjusted life years (QALYs). Participants were randomly assigned to fill out the survey for three or four age frames: a hypothetical person of 10, 15, 40, and 70 years (the last one only applicable to China) to allow the age dependency of the responses to be explored.

Results

A total of 1,234 Dutch and 1,818 Chinese people administered the survey. Controlling for time preferences, we found that the agreement of health state values for different age frames was generally stronger in the Netherlands than in China. We found no clear pattern of differences in the QALY composition in both samples. The probability distribution over response options varied most when levels for lifespan or severity were at the extremes of the spectrum.

Conclusion/discussion

The magnitude and direction of age effects on values seemed dimension- and country specific. In the Netherlands, we found a few differences in dimension-specific weights elicited for 10- and 15-year-olds compared to 40-year-olds, but the overall age dependency of values was limited. A stronger age dependency of values was observed in China, where values for 70-year-olds differed strongly from the values for other ages. The appropriateness of using existing values beyond the age range for which they were measured needs to be evaluated in the local context.
The 18-item Swedish version of Ryff’s psychological wellbeing scale: psychometric properties based on classical test theory and item response theory
Authors: Garcia Danilo , Kazemitabar Maryam , Asgarabad Mojtaba Habibi
Published: October 2023

Background

Psychological wellbeing is conceptualized as the full engagement and optimal performance in existential challenges of life. Our understanding of psychological wellbeing is important for us humans to survive, adapt, and thrive during the challenges of the 21st century. Hence, the measurement of psychological wellbeing is one cornerstone for the identification and treatment of both mental illness and health promotion. In this context, Ryff operationalized psychological wellbeing as a six-dimensional model of human characteristics: self-acceptance, positive relations with others, environmental mastery, personal growth, autonomy, and purpose in life. Ryff’s Psychological Wellbeing Scale has been developed and translated into different versions. Here, we examine and describe the psychometric properties of the 18-item Swedish version of Ryff’s Psychological Wellbeing Scale using both Classical Test Theory (CTT) and Item Response Theory (IRT).

Methods

The data used in the present study was earlier published elsewhere and consists of 768 participants (279 women and 489 men). In addition to the 18-item version of the scale, participants answered the Temporal Satisfaction with Life Scale, the Positive Affect Negative Affect Schedule, and the Background and Health Questionnaire. We examined, the 18-item version’s factor structure using different models and its relationship with subjective wellbeing, sociodemographic factors (e.g., education level, gender, age), lifestyle habits (i.e., smoking, frequency of doing exercise, and exercise intensity), and health issues (i.e., pain and sleeping problems). We also analyzed measurement invariance with regard to gender. Moreover, as an addition to the existing literature, we analyzed the properties of the 18 items using Graded Response Model (GRM).

Results

Although the original six-factor structure showed a good fit, both CTT and IRT indicated that a five-factor model, without the purpose in life subscale, provided a better fit. The results supported the internal consistency and concurrent validity of the 18-item Swedish version. Moreover, invariance testing showed similar measurement precision by the scale across gender. Finally, we found several items, especially the purpose in life’s item “I live life one day at a time and do not really think about the future,” that might need revision or modification in order to improve measurement.

Conclusion

A five-factor solution is a valid and reliable measure for the assessment of psychological wellbeing in the general Swedish population. With some modifications, the scale might achieve enough accuracy to measure the more appropriate and correct six-dimensional theoretical framework as detailed by Ryff. Fortunately, Ryff’s original version contains 20 items per subscale and should therefore act as a perfect pool of items in this endeavor.
Demands and stress before and during the COVID-19 pandemic of parents to children with autism spectrum disorder
Authors: Sartor Teresa , Sons Sarah , Kunina-Habenicht Olga , Tröster Heinrich , Kuhn Jörg-Tobias
Published: October 2023

Introduction

Parents to children with Autism Spectrum Disorder (ASD) face diverse daily demands that can lead to stress. The aim of this study was to examine to which extent stress in parents to children with ASD can be explained by daily demands before and during the COVID-19 pandemic (after lockdowns; first half of 2022), and whether there are differences between the two time periods in this regard.

Methods

Data from parents to children with ASD living in Germany from two independent questionnaire studies (before the pandemic: N = 168, during the pandemic: N = 105) were matched for comparability. Simple and multiple linear regression analyses were used to answer the research question.

Results

Parental stress as well as all demands examined showed higher levels during the COVID-19 pandemic than before. Significant predictors of parental stress before and during the COVID-19 pandemic were (1) the daily demands to deal with the child’s problem behavior, (2) the restriction of one’s personal way of life, and (3) the challenge to cooperate with the partner. During the COVID-19 pandemic, the child’s problem behavior was particularly relevant. It was also found that the demand to deal with stigmatizing reactions did not explain parental stress during the COVID-19 pandemic whereas before the pandemic it had been a significant predictor.

Discussion

Although parental stress and the demands of daily life increased during the pandemic, most of the stress can be explained by the same demands. It is suggested that the increased levels may be due to an increase in the child’s ASD symptomatology, which is why it is advisable to install therapeutic and care structures that prepare children with ASD for future crises.
Self-dehumanisation in voice hearers: the end of a continuum
Authors: O’Brien-Venus Bethany , Jenkins Tom , Chadwick Paul
Published: October 2023

Background

Meta-dehumanisation and self-dehumanisation have been identified as potentially relevant phenomena for developing a deeper understanding of distress related to voice-hearing, particularly those experiencing voices as part of psychosis. Chadwick has previously argued that those with psychosis, including those who hear distressing voices, typically feel “dehumanised and set apart by their experiences of psychosis and trauma.” The present study explores the subjective experience of self-dehumanisation in people who experience distressing voices, which was selected as a useful starting point to inform future research focused on understanding dehumanisation in people with psychosis.

Methods

Qualitative data was obtained through twenty semi-structured interviews with self-identifying voice hearers and analysed using reflexive thematic analysis. This followed the recursive six phase procedure of Braun and Clarke, and this was conducted from a critical realist, contextualist position.

Results

Reflexive thematic analysis of participant’s experiences produced a core theme, Dehumanisation as the End of Experiential Continua, and six subthemes: Extent of Distressing Sensory Fragmentation; Sense of Belonging with Other Humans; Integrity of Self as a Private, Coherent Entity; Sense of Worth as a Human Being; Strength of Personal Agency; and Trust in Own Credibility and Reliability. Two further themes, The Push and Pull of Dehumanising Forces and Reclaiming Life through Humanising Forces, were identified. Findings were presented to a panel of five experts by experience, all with lived experience of psychosis and service-use; all five strongly endorsed the themes as fitting with and expressing their own experiences of self-dehumanisation.

Conclusion

Reflexive thematic analysis of voice hearers’ accounts identified self-dehumanisation as the endpoint where six experiential continua coalesce. Experiential movement along these continua was affected by a range of interpersonal, intrapersonal, and societal forces over time, including dehumanising attitudes of others and voice malevolence and omnipotence. Future research might examine if and how psychological therapies aimed at those experiencing distressing voices, such as people experiencing psychosis may address feelings of self-dehumanisation.
A qualitative exploration of the lived experiences of Body Dysmorphic Disorder
Authors: Brennan Sarah N. , Rossell Susan L. , Rehm Imogen , Thomas Neil , Castle David J.
Published: October 2023

Body Dysmorphic Disorder (BDD) is characterized by an intense preoccupation with one or more perceived “defects” in physical appearance. Despite the distress and impairment associated with BDD, the disorder remains understudied and poorly understood. In particular, there are limited studies available which give voice to those with firsthand experiences of the disorder. A qualitative approach was employed to study lived experience of BDD. In-depth semi-structured interviews were conducted with 12 participants with BDD, aiming to understand their subjective experiences of the disorder. Data was analyzed using Interpretative Phenomenological Analysis (IPA). The results identified three superordinate themes; (1) consumed by the disorder, (2) the flawed self, and (3) intolerance of uncertainty about appearance. The qualitative findings of this study are discussed in relation to current conceptual understandings of BDD, including the cognitive behavioral model.
Deficits in specific executive functions manifest by severity in major depressive disorder: a comparison of antidepressant naïve inpatient, outpatient, subclinical, and healthy control groups
Authors: Malekizadeh Hossein , Saed Omid , Rashtbari Alireza , Sajjadi Mozhdeh , Ahmadi Davoud , Ronold Eivind Haga
Published: October 2023

Introduction

Previous research has highlighted the executive function (EF) deficits present in depressed patients; however, conflicting results exist regarding the impact of depression severity on the size of these deficits. This study aimed to compare deficits in EF between antidepressant naïve inpatient and outpatient depressed, a group with subclinical depression symptoms, and a healthy control group while controlling for education, sex, and age.

Methods

In cross-sectional research, 245 antidepressant naive participants (46 inpatient, 68 outpatient, 65 subclinical, and 67 healthy control individuals) were recruited by convenience sampling. The Structured Clinical Interview for DSM-5 Disorders (SCID-5) and Beck Depression Inventory-II (BDI-II) were used to assess depression. EF was measured using several neuropsychological tests, including the Stroop Color-Word Test, the Wisconsin Card Sorting Test, and the N-back Test, which assessed the components of Inhibition, Shifting, and Updating, respectively. Multivariate analysis of covariance revealed a significant difference between the groups in EF components (p < 0.001). Pairwise comparisons further showed that inpatient and outpatient patients had more depressive symptoms and worse EF performance than subclinical and healthy control groups (p < 0.05).

Results

In the analysis of EF measures, a significant difference was found among the four groups, with post-hoc tests revealing variations in specific EF components. Overall, patients with more severe depressive symptoms show more deficits in EF. Additionally, correlations between clinical characteristics and EF measures varied across patient groups, but many correlations became non-significant after adjusting for the false discovery rate (FDR).

Discussion

This study emphasizes the impact of depression severity on deficits in the EF of depressed patients and at-risk populations. Consequently, it is important to consider executive dysfunctions as an underlying vulnerability in the development and persistence of depressive disorder.
Music for autism: a protocol for an international randomized crossover trial on music therapy for children with autism
Authors: Ruiz Marianna , Groessing Alexander , Guran Alexandrina , Koçan Asena U. , Mikus Nace , Nater Urs M. , Kouwer Karlijn , Posserud Maj-Britt , Salomon-Gimmon Maayan , Todorova Boryana , Wagner Isabella C. , Gold Christian , Silani Giorgia , Specht Karsten
Published: October 2023

The notion of a connection between autism and music is as old as the first reported cases of autism, and music has been used as a therapeutic tool for many decades. Music therapy holds promise as an intervention for individuals with autism, harnessing their strengths in music processing to enhance communication and expression. While previous randomized controlled trials have demonstrated positive outcomes in terms of global improvement and quality of life, their reliance on psychological outcomes restricts our understanding of underlying mechanisms. This paper introduces the protocol for the Music for Autism study, a randomized crossover trial designed to investigate the effects of a 12-week music therapy intervention on a range of psychometric, neuroimaging, and biological outcomes in school-aged children with autism. The protocol builds upon previous research and aims to both replicate and expand upon findings that demonstrated improvements in social communication and functional brain connectivity following a music intervention. The primary objective of this trial is to determine whether music therapy leads to improvements in social communication and functional brain connectivity as compared to play-based therapy. In addition, secondary aims include exploring various relevant psychometric, neuroimaging, and biological outcomes. To achieve these objectives, we will enroll 80 participants aged 6–12 years in this international, assessor-blinded, crossover randomized controlled trial. Each participant will be randomly assigned to receive either music therapy or play-based therapy for a period of 12 weeks, followed by a 12-week washout period, after which they will receive the alternate intervention. Assessments will be conducted four times, before and after each intervention period. The protocol of the Music for Autism trial provides a comprehensive framework for studying the effects of music therapy on a range of multidimensional outcomes in children with autism. The findings from this trial have the potential to contribute to the development of evidence-based interventions that leverage strengths in music processing to address the complex challenges faced by individuals with autism.

Clinical Trial Registration: Clinicaltrials.gov identifier NCT04936048.
Impact of social isolation caused by the COVID-19 pandemic on the mood profile of active and sedentary older adults: physical activity as a protective factor
Authors: Andrade Alexandro , D’Oliveira Anderson , dos Santos Keyla Mara , Bastos Ana Cecilia Rosatelli de Freitas , Corrado Stefano , Vilarino Guilherme Torres , Diotaiuti Pierluigi
Published: October 2023

Background

The COVID-19 pandemic has changed our habits and lifestyle due to social isolation and mobility restrictions. This new scenario, together with the fear of contracting the coronavirus, influenced mental health, especially among older adults, who presented reductions in social contact and physical activity (PA). Thus, the objective of the study was to analyze the impact caused by social isolation during the COVID-19 pandemic on the mood states of active and sedentary older adults.

Methods

This is an observational study conducted during the COVID-19 pandemic. Older adults aged over 60 years, who were registered in the database of the Secretariat for the Promotion of Citizenship from a city in southern Brazil, participated in the research. An online questionnaire was applied with questions about sociodemographic characteristics, level of PA, confinement, and mood states in two periods: May 2020 and June 2021. The Mann–Whitney U test was used to compare the mood states of active and inactive individuals during the pandemic.

Results

One hundred and fifty participants answered the questionnaire, of which 80 (53.3%) reported practicing PA. More active older adults suffered fewer changes in mood when compared to inactive older adults, with lower levels of confusion (p = 0.035), depression (p = 0.002), and fatigue (p = 0.000). Older adults confined for more than 50 days were more likely to develop depression. In addition, the mood state correlated with the variable fear of contracting the coronavirus; the greater the fear, the greater the mental confusion, depression, fatigue, and tension, and the lower the vigor in the older adults. The practice of PA is also correlated with the mood state; the greater the number of hours dedicated to PA, the lower the confusion, depression, fatigue, and tension of the older adults.

Conclusion

The practice of PA positively influenced the mental health of older adults during periods of isolation and social restrictions. PA has a protective factor for the development of mental health problems and improves mood states, with greater time performing PA leading to more benefits.
Food is medicine intervention shows promise for engaging patients attending a safety-net hospital in the Southeast United States
Authors: Owens Caroline , Cook Miranda , Goetz Joy , Marshburn Leslie , Taylor Kathy , Schmidt Stacie , Bussey-Jones Jada , Chakkalakal Rosette J.
Published: October 2023

Public health organizations, including the Academy of Nutrition and Dietetics and the American Hospital Association, recognize the importance of achieving food and nutrition security to improve health outcomes, reduce healthcare costs, and advance health equity. In response, federal, state, and private agencies are increasingly seeking to fund healthcare-based interventions to address food insecurity among patients. Simultaneously, nutrition-based interventions targeting chronic diseases have grown across the United States as part of the broader “Food is Medicine” movement. Few studies have examined the successes, challenges, and limitations of such efforts. As Food is Medicine programs continue to expand, identifying common approaches, metrics, and outcomes will be imperative for ensuring program success, replicability, and sustainability. Beginning in 2020, the Food as Medicine (FAM) program, a multipronged, collaborative intervention at Grady Health System has sought to combat food insecurity and improve patient health by leveraging community resources, expertise, and existing partnerships. Using this program as a case study, we (1) outline the collaborative development of the FAM program; (2) describe and characterize patient engagement in the initial 2 years; and (3) summarize strengths and lessons learned for future hospital-based food and nutrition programming. As this case study illustrates, the Food as Medicine program provides a novel model for building health equity through food within healthcare organizations.
The synergistic effect of high temperature and ozone on the number of deaths from circulatory system diseases in Shijiazhuang, China
Authors: Fu Guiqin , Cheng Haimin , Lu Qian , Liu Huayue , Zhang Xiaohui , Zhang Xingshan
Published: October 2023

Introduction

Urban ozone pollution in China is becoming increasingly serious. Climate warming, high temperatures, and ozone pollution all have significant impacts on human health. However, the synergistic effects of high temperatures and ozone pollution in summer on human health are rarely studied. China is at a critical stage of environmental pollution control. Assessing the health impact of high temperatures and ozone exposure on the number of deaths from circulatory diseases is of great significance for formulating ozone-related prevention and control policies.

Methods

This study uses daily data on deaths from circulatory system diseases in Shijiazhuang from June to August during the summer of 2013–2016, as well as concurrent meteorological data and concentration of O3 and PM2.5 pollution data. The generalized additive model (GAM) with Poisson distribution, smooth curve threshold effect, and saturation effect method is used to control for confounding effects.

Results

The study evaluates the impact of short-term exposure to temperature and ozone on deaths from circulatory system diseases and the synergistic effect after controlling for confounding factors. The results show that the impact of temperature and ozone on deaths from circulatory system diseases in Shijiazhuang is nonlinear, with a temperature threshold of 27.5°C and an ozone concentration threshold of 100 μg/m3. With an increase of temperature by 1°C, the risk of deaths for total population, men and women are 6.8%, 4.6% and 9.3%, respectively. The increase in temperature and ozone concentration has a greater impact on women; in men, the increase has a lag effect of 2 to 3 days, but the lag did not affect women.

Discussion

In conclusion, high temperatures and high ozone concentration have synergistic enhancement effects on circulatory system diseases. Prevention and scientific management strategies of circulatory system diseases in high temperatures and high ozone environments should be strengthened.
Dense gas star formation efficiency and the LHCN (4−3)′/LHCO+(4−3)′ ratio: insights from a statistical study of infrared bright star-forming galaxies
Authors: Jiao Qian , Gao Yu , Tan Qinghua , Gao Yang
Published: October 2023

We present a statistical study on dense molecular gas tracers of HCN (4–3), HCO+ (4–3) lines and molecular tracers of [C i], and CO observations for a sample of 26 infrared bright star-forming (SF) galaxies. We investigate the dependence of dense gas star formation efficiency traced by HCN (4–3), HCO+ (4–3) (that is LIR/LHCN (4-3)′, and LIR/LHCO+(4−3)′), and luminosity ratio of LHCN (4-3)′/LHCO+(4−3)′ on [C i]-CO ratios of L[C I] (1-0)′/LCO (1-0)′, L[C I] (2-1)′/LCO (1-0)′ and L[C I] (2-1)′/L[C I] (1-0)′ (hereafter R[CI]) which are sensitive to interstellar medium conditions. Our findings show that both LIR/LHCN (4-3)′ and LIR/LHCO+(4−3)′ have moderate correlations with L[C I] (2-1)′/LCO (1-0)′ and R[CI], while LHCN (4-3)′/LHCO+(4−3)′ does not show any significant correlations with any of the [C i]-CO ratios. We compare the LHCN (4-3)′/LHCO+(4−3)′ ratios of AGN and SF galaxies, and find that although the higher LHCN (4-3)′/LHCO+(4−3)′ ratios are mainly found in AGN, the majority of the LHCN (4-3)′/LHCO+(4−3)′ values in SF galaxies are comparable to those in AGN. Based on our findings, it appears that the LHCN (4-3)′/LHCO+(4−3)′ ratio may not be a reliable indicator of the presence of an AGN, although further investigation is needed to confirm this conclusion.
Influence of CrossFit and Deep End Fitness training on mental health and coping in athletes
Authors: Cansler Rachel , Heidrich Jerome , Whiting Ali , Tran Don , Hall Prime , Tyler William J.
Published: October 2023

Physical exercise is known to improve mental health. Athletes can experience unique physical and emotional stressors, which can deteriorate mental health and cognitive function. Training apathy can lead to cognitive dissonance and further degrade performance by promoting maladaptive, avoidance coping strategies. Introduction of psychosocial and training variables, such as those used in CrossFit (CF) and other community-based fitness programs with strong peer support have been shown to help reduce training apathy and negative affect. Here, we explored whether addition of psychophysiological variation, experienced as “hunger for air” during underwater breath-hold exercises, could provide unique mental health benefits for athletes. We studied the influence of CF and Deep End Fitness (DEF), a community-based underwater fitness program, on several outcome measures of mental health and emotional well-being in volunteer athletes. We observed a significant reduction in stress scores of both the control CF training group and the experimental DEF group. We found that DEF produced a significant improvement in positive affect while CF training did not. Further supportive of our hypothesis that the psychological and biological stressors experienced in underwater, breath-hold training cause positive adaptive changes and benefits, DEF training uniquely increased problem-based coping. While our observations demonstrate both CF and DEF training can improve mental health in athletes, DEF produced additional, unique benefits to positive coping and attitudes of athletes. Future studies should further evaluate the broader benefits of community-based, underwater training programs on psychological and physiological health in athletes and the public.
Cytokine-Induced iNOS in A549 Alveolar Epithelial Cells: A Potential Role in COVID-19 Lung Pathology
Authors: Barilli Amelia , Recchia Luciani Giulia , Visigalli Rossana , Sala Roberto , Soli Maurizio , Dall’Asta Valeria , Rotoli Bianca Maria
Published: October 2023

Background. In COVID-19, an uncontrolled inflammatory response might worsen lung damage, leading to acute respiratory distress syndrome (ARDS). Recent evidence points to the induction of inducible nitric oxide synthase (NOS2/iNOS) as a component of inflammatory response since NOS2 is upregulated in critical COVID-19 patients. Here, we explore the mechanisms underlying the modulation of iNOS expression in human alveolar cells. Methods. A549 WT and IRF1 KO cells were exposed to a conditioned medium of macrophages treated with SARS-CoV-2 spike S1. Additionally, the effect of IFNγ, IL-1β, IL-6, and TNFα, either alone or combined, was addressed. iNOS expression was assessed with RT-qPCR and Western blot. The effect of baricitinib and CAPE, inhibitors of JAK/STAT and NF-kB, respectively, was also investigated. Results. Treatment with a conditioned medium caused a marked induction of iNOS in A549 WT and a weak stimulation in IRF1 KO. IFNγ induced NOS2 and synergistically cooperated with IL-1β and TNFα. The inhibitory pattern of baricitinb and CAPE indicates that cytokines activate both IRF1 and NF-κB through the JAK/STAT1 pathway. Conclusions. Cytokines secreted by S1-activated macrophages markedly induce iNOS, whose expression is suppressed by baricitinib. Our findings sustain the therapeutic efficacy of this drug in COVID-19 since, besides limiting the cytokine storm, it also prevents NOS2 induction.
History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines
Authors: Rustia Jessica M. , Antonino Judith P. , Velasco Ravelina R. , Lima Marcelo A. , Yates Edwin A. , Fernig David G.
Published: October 2023

The windowpane oyster Placuna placenta lives in brackish coastal waters and has long been economically important to the Philippines because of its durable and translucent shell, which is used as a glass substitute and material for making windowpanes and handicrafts. There has been considerable degradation of the P. placenta fishery over the past decades. Moreover, there are waste and under-exploited by-products, such as the meat, which though nutritious and edible, currently has a very low value; its use is confined to dishes consumed by families in the fishing community. Historically, there have been instances of excellent practice in terms of regulating the P. placenta fishery, while in recent times, there have been local initiatives to restore this and to develop high-value food products from the meat. These initiatives have, however, never been followed through at a provincial or national level. Research on other molluscs and marine organisms highlights that these contain high-value pharmaceutical products, an unexplored facet of P. placenta. This review compiles evidence to establish the groundwork for an essential and comprehensive multidisciplinary research programme centred around the P. placenta, which would ensure a high value for all parts of the oyster, including those currently discarded. By fostering a sustainable and circular economy within this fishery sector and its associated industry, its economic value would be amplified. This is particularly important for oyster harvesters in the Philippines, who often find themselves on the economic ladder’s lower rungs. By integrating the principles of a circular economy, this initiative would not only aim to uplift the economic prospects of these harvesters, but in doing so would drive the restoration of P. placenta to its former range.
The Potential for the Use of Edible Insects in the Production of Protein Supplements for Athletes
Authors: Zielińska Ewelina , Pankiewicz Urszula
Published: October 2023

Several types of proteins are used in athletes’ supplementation; nevertheless, given the problem of protein deficiency in the world and the growing need for ecological sources of protein, it is very interesting to study the quality of alternative protein sources, such as insect protein. This study investigated the nutritional value, micronutrient content, amino acid profile, and chemical score of banded cricket protein quality in the form of flour, defatted flour, and a protein preparation, as well as popular commercial protein supplements. In addition, in vitro digestion was performed, and the antiradical activity of the hydrolysates was compared. Generally, the defatted cricket flour was the most similar to commercial supplements regarding nutritional value because it contained 73.68% protein. Furthermore, the defatted flour was abundant in essential minerals, such as iron (4.59 mg/100 g d.w.), zinc (19.01 mg/100 g d.w.), and magnesium (89.74 mg/100 g d.w.). However, the protein preparation had an amino acid profile more similar to that of commercial supplements (total content of 694 mg/g protein). The highest antiradical activity against ABTS·+ was noted for the defatted flour (0.901 mM TE/100 g) and against DPPH· for the cricket flour (2.179 mM TE/100 g). Therefore, cricket can be considered an organic protein source for the production of valuable protein supplements.
An Intelligent System to Improve Diagnostic Support for Oral Squamous Cell Carcinoma
Authors: Fonseca Afonso U. , Felix Juliana P. , Pinheiro Hedenir , Vieira Gabriel S. , Mourão Ýleris C. , Monteiro Juliana C. G. , Soares Fabrizzio
Published: October 2023

Oral squamous cell carcinoma (OSCC) is one of the most-prevalent cancer types worldwide, and it poses a serious threat to public health due to its high mortality and morbidity rates. OSCC typically has a poor prognosis, significantly reducing the chances of patient survival. Therefore, early detection is crucial to achieving a favorable prognosis by providing prompt treatment and increasing the chances of remission. Salivary biomarkers have been established in numerous studies to be a trustworthy and non-invasive alternative for early cancer detection. In this sense, we propose an intelligent system that utilizes feed-forward artificial neural networks to classify carcinoma with salivary biomarkers extracted from control and OSCC patient samples. We conducted experiments using various salivary biomarkers, ranging from 1 to 51, to train the model, and we achieved excellent results with precision, sensitivity, and specificity values of 98.53%, 96.30%, and 97.56%, respectively. Our system effectively classified the initial cases of OSCC with different amounts of biomarkers, aiding medical professionals in decision-making and providing a more-accurate diagnosis. This could contribute to a higher chance of treatment success and patient survival. Furthermore, the minimalist configuration of our model presents the potential for incorporation into resource-limited devices or environments.
Before Is Better: Innovative Multidisciplinary Preconception Care in Different Clinical Contexts
Authors: Cristodoro Martina , Dell’Avanzo Marinella , Ghio Matilda , Lalatta Faustina , Vena Walter , Lania Andrea , Sacchi Laura , Bravo Maria , Bulfoni Alessandro , Di Simone Nicoletta , Inversetti Annalisa
Published: October 2023

Context: Implementation of pre-conception care units is still very limited in Italy. Nowadays, the population’s awareness of the reproductive risks that can be reduced or prevented is very low. Purpose and main findings: We presented a new personalized multidisciplinary model of preconception care aimed at identifying and possibly reducing adverse reproductive events. We analyzed three cohorts of population: couples from the general population, infertile or subfertile couples, and couples with a previous history of adverse reproductive events. The proposal involves a deep investigation regarding family history, the personal histories of both partners, and reproductive history. Principal conclusions: Preconception care is still neglected in Italy and under-evaluated by clinicians involved in natural or in vitro reproduction. Adequate preconception counseling will improve maternal and fetal obstetrical outcomes.
A Numerical Study on the Performance of the 66k DWT Bulk Carrier in Regular and Irregular Waves
Authors: Kim Gu-Hyeon , Hwang Seunghyun , Lee Soon-Hyun , Lee Jun-Hee , Hwangbo Jun , Kim Kwang-Soo , Paik Kwang-Jun
Published: October 2023

Accurate resistance performance evaluation is essential to predict the minimum propulsion horsepower required for ships in real sea. Therefore, in this paper, the added resistance performance of K-Supramax in various wave conditions was calculated using CFD (Computational Fluid Dynamics). First, to compare the resistance performance according to the DOF (Degree of Freedom), the added resistance performance in the head regular wave was investigated and compared with the experiment. The 2DOF and 6DOF results in the head regular wave had no significant differences. Second, to compare the resistance performance among various wave conditions, the effect of the heading angle was analyzed by comparing resistance and motion RAOs (Response Amplitude Operators) in bow quartering sea conditions using 6DOF. The added resistance showed the highest value near the resonance frequency of 170°. As the heading angle increased, the added resistance tended to decrease, regardless of the wavelength ratio. Also, the added resistance performance in irregular waves was investigated with reference to the adverse conditions. The spectral method, which linearly superimposes regular wave results, and the added resistance generated during irregular waves directly through CFD were compared. The resistance in irregular waves increased by approximately 92% for the spectral method and by approximately 72% for the direct irregular wave calculation compared to the resistance in calm water. In addition, the PSD (Power Spectral Density) of resistance and the distribution of motion RAOs obtained from direct irregular wave calculations were investigated.