bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study of Analytical Solution for the Special Dissolution Rate Model of Rock Salt
Authors: Yang Xin , Liu Xinrong , Zang Wanjun , Lin Zhiyong , Wang Qiyun
Published: June 2017

By calculating the concentration distributions of rock salt solutions at the boundary layer, an ordinary differential equation for describing a special dissolution rate model of rock salt under the assumption of an instantaneous diffusion process was established to investigate the dissolution mechanism of rock salt under transient but stable conditions. The ordinary differential equation was then solved mathematically to give an analytical solution and related expressions for the dissolved radius and solution concentration. Thereafter, the analytical solution was fitted with transient dissolution test data of rock salt to provide the dissolution parameters at different flow rates, and the physical meaning of the analytical formula was also discussed. Finally, the influential factors of the analytical formula were investigated. There was approximately a linear relationship between the dissolution parameters and the flow rate. The effects of the dissolution area and initial volume of the solution on the dissolution rate equation of rock salt were computationally investigated. The results showed that the present analytical solution gives a good description of the dissolution mechanism of rock salt under some special conditions, which may provide a primary theoretical basis and an analytical way to investigate the dissolution characteristics of rock salt.
Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway
Authors: Feng Pei-pei , Deng Pu , Liu Li-hua , Ai Qi , Yin Jie , Liu Zhe , Wang Gai-mei
Published: June 2017

Neuroinflammation has been suggested to be involved in the pathogenesis of postoperative cognitive dysfunction (POCD). Electroacupuncture (EA) is an irreplaceable method in traditional Chinese medicine that is used for treating neurodegenerative diseases in clinical and experimental studies. The aim of this study was to examine whether EA improves cognitive dysfunction caused by surgery and to investigate the pathological mechanism of TLR2 and TLR4 in the hippocampus of aged rats. A rat model of POCD was established and treated with EA or minocycline. Both EA‐ and minocycline‐treated rats performed significantly better than untreated operated rats in spatial memory tasks of the Morris water maze (MWM) test, spending comparatively greater amounts of time in the target zone during the probe test. Additionally, decreased levels of proinflammatory cytokines (IL‐1β, IL‐6, TNF‐α, and HMGB1) and decreased TLR2 and TLR4 protein expression in the hippocampus of EA‐ and minocycline‐treated rats were detected. Our data suggested that EA treatment alleviated the cognition performance deficit and neuroinflammation in aged rats following surgery, which may be mediated by inhibiting the expression of hippocampal neuroinflammatory cytokines through the microglia/TLR2/4 pathway.
A Novel Condition to the Harmonic of the Velocity Vector Field of a Curve in Rn
Authors: Altın Ayşe , Köroğlu Canan
Published: June 2017

In this paper, a condition is obtained for the harmonic of the velocity vector field in the curve family passing through the fixed p and q points in Rn. It shows that the condition can be expressed in terms of the curvature functions. Finally, we give an example which provides the mentioned condition in this work and illustrates it with figures.
Hydrogen Sulfide Inhibits Autophagic Neuronal Cell Death by Reducing Oxidative Stress in Spinal Cord Ischemia Reperfusion Injury
Authors: Xie Lei , Yu Sifei , Yang Kai , Li Changwei , Liang Yu
Published: June 2017

Autophagy is upregulated in spinal cord ischemia reperfusion (SCIR) injury; however, its expression mechanism is largely unknown; moreover, whether autophagy plays a neuroprotective or neurodegenerative role in SCIR injury remains controversial. To explore these issues, we created an SCIR injury rat model via aortic arch occlusion. Compared with normal controls, autophagic cell death was upregulated in neurons after SCIR injury. We found that autophagy promoted neuronal cell death during SCIR, shown by a significant number of terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling‐ (TUNEL‐) positive cells colabeled with the autophagy marker microtubule‐associated protein 1 light chain 3, while the autophagy inhibitor 3‐methyladenine reduced the number of TUNEL‐positive cells and restored neurological and motor function. Additionally, we showed that oxidative stress was the main trigger of autophagic neuronal cell death after SCIR injury and N‐acetylcysteine inhibited autophagic cell death and restored neurological and motor function in SCIR injury. Finally, we found that hydrogen sulfide (H2S) inhibited autophagic cell death significantly by reducing oxidative stress in SCIR injury via the AKT‐the mammalian target of rapamycin (mTOR) pathway. These findings reveal that oxidative stress induces autophagic cell death and that H2S plays a neuroprotective role by reducing oxidative stress in SCIR.
Lycium barbarum Reduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome
Authors: de Souza Zanchet Mayara Zagonel , Nardi Geisson Marcos , de Oliveira Souza Bratti Letícia , Filippin-Monteiro Fabíola Branco , Locatelli Claudriana
Published: June 2017

Natural antioxidants present in fruits have attracted considerable interest due to their presumed safety and potential nutritional value. Even though antioxidant activities of many fruits have been reported, the effects of phytochemicals of goji berry (GB) in patients with metabolic syndrome have not been investigated. In this study, we examined anthropometric and biochemical parameters in patients with metabolic syndrome after the consumption of GB. The patients were divided into two groups, control (C) and supplemented (S), and followed up for 45 days. Participants were individually instructed to carry out a healthy diet, but additionally, an inclusion of 14 g of the natural form of goji berry in the diet during 45 days for the S group was proposed. After 45 days of study, a significant reduction in transaminases as well as an improvement in lipid profile in the S group was observed. Likewise, a significant reduction in the waist circumference of the S group was observed when compared with that of the C group, and increased glutathione and catalase levels associated with a reduction of lipid peroxidation. These results suggest that this is an effective dietary supplement for the prevention of cardiovascular diseases in individuals with metabolic syndrome.
Immune-Related Tumor Response Dynamics in Melanoma Patients Treated with Pembrolizumab: Identifying Markers for Clinical Outcome and Treatment Decisions
Authors: Nishino Mizuki , Giobbie-Hurder Anita , Manos Michael P. , Bailey Nancy , Buchbinder Elizabeth I. , Ott Patrick A. , Ramaiya Nikhil H. , Hodi F. Stephen
Published: June 2017

Purpose: Characterize tumor burden dynamics during PD-1 inhibitor therapy and investigate the association with overall survival (OS) in advanced melanoma.

Experimental Design: The study included 107 advanced melanoma patients treated with pembrolizumab. Tumor burden dynamics were assessed on serial CT scans using irRECIST and were studied for the association with OS.

Results: Among 107 patients, 96 patients had measurable tumor burden and 11 had nontarget lesions alone at baseline. In the 96 patients, maximal tumor shrinkage ranged from −100% to 567% (median, −18.5%). Overall response rate was 44% (42/96; 5 immune-related complete responses, 37 immune-related partial responses). Tumor burden remained <20% increase from baseline throughout therapy in 57 patients (55%). Using a 3-month landmark analysis, patients with <20% tumor burden increase from baseline had longer OS than patients with ≥20% increase (12-month OS rate: 82% vs. 53%). In extended Cox models, patients with <20% tumor burden increase during therapy had significantly reduced hazards of death [HR = 0.19; 95% confidence interval (CI), 0.08–0.43; P < 0.0001 univariate; HR = 0.18; 95% CI, 0.08–0.41; P < 0.0001, multivariable]. Four patients (4%) experienced pseudoprogression; 3 patients had target lesion increase with subsequent response, which was noted after confirmed immune-related progressive disease (irPD). One patient without measurable disease progressed with new lesion that subsequently regressed.

Conclusions: Tumor burden increase of <20% from the baseline during pembrolizumab therapy was associated with longer OS, proposing a practical marker for treatment decision guides that needs to be prospectively validated. Pseudoprogressors may experience response after confirmed irPD, indicating a limitation of the current strategy for immune-related response evaluations. Evaluations of patients without measurable disease may require further attention. Clin Cancer Res; 23(16); 4671–9. ©2017 AACR.
Real-Time Transferrin-Based PET Detects MYC-Positive Prostate Cancer
Authors: Aggarwal Rahul , Behr Spencer C. , Paris Pamela L. , Truillet Charles , Parker Matthew F.L. , Huynh Loc T. , Wei Junnian , Hann Byron , Youngren Jack , Huang Jiaoti , Premasekharan Gayatri , Ranatunga Nimna , Chang Emily , Gao Kenneth T. , Ryan Charles J. , Small Eric J. , Evans Michael J.
Published: June 2017

Noninvasive biomarkers that detect the activity of important oncogenic drivers could significantly improve cancer diagnosis and management of treatment. The goal of this study was to determine whether 68Ga-citrate (which avidly binds to circulating transferrin) can detect MYC-positive prostate cancer tumors, as the transferrin receptor is a direct MYC target gene. PET imaging paired with 68Ga-citrate and molecular analysis of preclinical models, human cell-free DNA (cfDNA), and clinical biopsies were conducted to determine whether 68Ga-citrate can detect MYC-positive prostate cancer. Importantly, 68Ga-citrate detected human prostate cancer models in a MYC-dependent fashion. In patients with castration-resistant prostate cancer, analysis of cfDNA revealed that all patients with 68Ga-citrate avid tumors had a gain of at least one MYC copy number. Moreover, biopsy of two PET avid metastases showed molecular or histologic features characteristic of MYC hyperactivity. These data demonstrate that 68Ga-citrate targets prostate cancer tumors with MYC hyperactivity. A larger prospective study is ongoing to demonstrate the specificity of 68Ga-citrate for tumors with hyperactive MYC.

Implications: Noninvasive measurement of MYC activity with quantitative imaging modalities could substantially increase our understanding of the role of MYC signaling in clinical settings for which invasive techniques are challenging to implement or do not characterize the biology of all tumors in a patient. Moreover, measuring MYC activity noninvasively opens the opportunity to study changes in MYC signaling in patients under targeted therapeutic conditions thought to indirectly inhibit MYC. Mol Cancer Res; 15(9); 1221–9. ©2017 AACR.
rs10767664 Gene Variant in Brain-Derived Neurotrophic Factor Is Associated with Diabetes Mellitus Type 2 in Caucasian Females with Obesity
Authors: de Luis Daniel Antonio , Aller Rocío , Izaola Olatz , Primo David , Romero Enrique
Published: June 2017

Background: The role of brain-derived neurotrophic factor (BDNF) variants on diabetes prevalence, basal adipokine levels, body weight, and cardiovascular risk factors remains unclear in obese patients. Objective: This study is aimed at analyzing the effects of rs10767664 BDNF gene polymorphism on diabetes mellitus prevalence, body weight, cardiovascular risk factors, and serum adipokine levels in obese female patients. Design: A total of 507 obese women were enrolled in a prospective way. Biochemical evaluation and anthropometric measures were recorded. Results: The frequency of diabetes mellitus in the group of patients with non-T allele was 20.1 and 28.3% in T-allele carriers. Logistic regression showed a risk of diabetes mellitus of 1.33 (95% CI 1.17-2.08) in subjects with T allele adjusted by age and body mass index (BMI). T-allele carriers with diabetes mellitus have a higher weight, BMI, waist circumference, blood pressure, glucose, homeostasis model assessment insulin resistance (HOMA-IR), insulin, and C-reactive protein (CRP) levels than non-T-allele carriers. Conclusion: rs10767664 polymorphism of BDNF gene is associated with prevalence of diabetes mellitus in obese female patients. T-allele carriers with diabetes mellitus have a higher weight, fat mass, blood pressure, level of insulin, glucose, HOMA-IR, and CRP than non-T-allele carriers.
Association of Blood Fatty Acid Composition and Dietary Pattern with the Risk of Non-Alcoholic Fatty Liver Disease in Patients Who Underwent Cholecystectomy
Authors: Shim Poyoung , Choi Dongho , Park Yongsoon
Published: June 2017

Background/Aims: The relationship between diet and non-alcoholic fatty liver disease (NAFLD) in patients with gallstone disease and in those who have a high risk for NAFLD has not been investigated. This study was conducted to investigate the association between the risk of NAFLD and dietary pattern in patients who underwent cholecystectomy. Additionally, we assessed the association between erythrocyte fatty acid composition, a marker for diet, and the risk of NAFLD. Methods: Patients (n = 139) underwent liver ultrasonography to determine the presence of NAFLD before laparoscopic cholecystectomy, reported dietary intake using food frequency questionnaire, and were assessed for blood fatty acid composition. Results: Fifty-eight patients were diagnosed with NAFLD. The risk of NAFLD was negatively associated with 2 dietary patterns: consuming whole grain and legumes and consuming fish, vegetables, and fruit. NAFLD was positively associated with the consumption of refined grain, meat, processed meat, and fried foods. Additionally, the risk of NAFLD was positively associated with erythrocyte levels of 16:0 and 18:2t, while it was negatively associated with 20:5n3, 22:5n3, and Omega-3 Index. Conclusion: The risk of NAFLD was negatively associated with a healthy dietary pattern of consuming whole grains, legumes, vegetables, fish, and fruit and with an erythrocyte level of n-3 polyunsaturated fatty acids rich in fish.
GAS6 Oncogene and Reverse MLLT3-KMT2A Duplications in an Infant with Acute Myeloid Leukemia and a Novel Complex Hyperdiploid Karyotype: Detailed High-Resolution Molecular Cytogenetic Studies
Authors: Capela de Matos Roberto R. , Ney Garcia Daniela R. , Cifoni Elaine , Othman Moneeb A.K. , Tavares de Souza Mariana , Carboni Edna K. , Ferreira Gerson M. , Liehr Thomas , Ribeiro Raul C. , M. Silva Maria Luiza
Published: June 2017

Pediatric acute myeloid leukemia (AML) is a highly heterogeneous disease, presenting cytogenetic and molecular abnormalities which turned out to be critical prognostic factors. Ploidy changes as gain or loss of individual chromosomes are rare in AML, occurring only in about 1-2% of the affected children. Hyperdiploid karyotypes are exceedingly rare in infants less than 12 months of age. In this age group, structural rearrangements involving the KMT2A gene occur in about 58% of the cases. Among them, the translocation t(9;11)(p22;q23), KMT2A-MLLT3, is the most common abnormality accounting for approximately 22% of KMT2A rearrangements in infant AML cases. Here, we describe a 7- month-old girl with a history of fever and severe diarrhea, and a physical examination remarkable for pallor and hepatosplenomegaly. A novel complex hyperdiploid karyotype 53,XX,+X,+6,t(9;11)(p21.3;q23.3),+der(9)t(9;11)(p21.3;q23.3),dup(13)(q31q34),+14,+19,+21,+22 was characterized by high-resolution molecular cytogenetic approaches. Fluorescence in situ hybridization, multiplex-FISH, and multicolor chromosome banding were applied, revealing 2 reverse MLLT3-KMT2A fusions and a duplication of the GAS6 oncogene. Our work suggests that molecular cytogenetic studies are crucial for the planning of a proper strategy for risk therapy in AML infants with hyperdiploid karyotypes.
New developments in anticoagulants: Past, present and future
Authors: Weitz Jeffrey I. , Harenberg Job
Published: June 2017

Thrombosis is a leading cause of death and disability worldwide, and anticoagulants are the mainstay of its prevention and treatment. Starting with unfractionated heparin (UFH) and vitamin K antagonists (VKAs) such as warfarin, the choices of anticoagulants have exploded in the past 20 years. With over 90% subcutaneous bioavailability, no need for coagulation monitoring and dose adjustment, and a lower risk of heparin-induced thrombocytopenia, low-molecular-weight heparin and fondaparinux have replaced UFH for prevention and initial treatment of venous thromboembolism and for secondary prevention in cancer patients. In patients undergoing percutaneous interventions, bivalirudin is often used instead of UFH. Oral anticoagulation therapy has advanced with the introduction of the non-vitamin K antagonist oral anticoagulants (NOACs), which include dabigatran, rivaroxaban, apixaban and edoxaban. With efficacy at least equal to that of VKAs but with greater safety and convenience, the NOACs are now replacing VKAs for many indications. This paper a) highlights these advances, b) outlines how specific reversal agents for the NOACs will enhance their safety, c) reviews some of the ongoing trials with the NOACs, and d) describes the inhibitors of factor XII and XI that are under investigation as anticoagulants.
Therapeutic strategies for atherosclerosis and atherothrombosis: Past, present and future
Authors: Weber Christian , Badimon Lina , Mach Francois , van der Vorst Emiel P. C.
Published: June 2017

Even two centuries after they were first described, atherosclerosis and atherothrombosis remain among the leading causes of death worldwide. Over the last decades it has become clear that atherosclerosis is not only a lipid-driven disease but also a multifactorial process largely driven by inflammatory mediators, an insight that has instigated additional research and drug development focussing on anti-inflammatory therapies. In this review, we will provide a brief historical overview, followed by a more general synopsis of the range of currently available state-of-the-art therapies for atherosclerosis and atherothrombosis. Finally, we will highlight some of the promising therapeutic strategies that are currently under intense investigation. We believe that the next years will witness highly interesting developments and clinical trials investigating yet more novel therapies, and at the same time looking into potential combinations of all available therapies. This prospect closes in on the ultimate goal, which is to reduce the residual risk that still persists despite present therapeutic options.
Induced Pluripotent Stem Cells 10 Years Later
Authors: Yoshida Yoshinori , Yamanaka Shinya
Published: June 2017

Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to embryonic stem cells, such as the capacity of self-renewal and differentiation into many types of cells, including cardiac myocytes. Although initially the reprogramming efficiency was low, several improvements in reprogramming methods have achieved robust and efficient generation of iPSCs without genomic insertion of transgenes. iPSCs display clonal variations in epigenetic and genomic profiles and cellular behavior in differentiation. iPSC-derived cardiac myocytes (iPSC cardiac myocytes) recapitulate phenotypic differences caused by genetic variations, making them attractive human disease models, and are useful for drug discovery and toxicology testing. In addition, iPSC cardiac myocytes can help with patient stratification in regard to drug responsiveness. Furthermore, they can be used as source cells for cardiac regeneration in animal models. Here, we review recent progress in iPSC technology and its applications to cardiac diseases.
Land-Water-Security Nexus: Changing Geopolitics in the Nile Basin Cooperative Framework Agreement
Authors: Olanya David Ross
Published: June 2017

This article extends the debate on the shift in water security governance in the Nile Basin countries. Water as an object of analysis was previously embedded in a depoliticized governance framework now faces politicization in the context of food, energy and climate change. In considering land-water-security nexus, population and climate variations drive Middle East and North Africa (mena) policies for the return of the state primacy in water governance. As Egypt and Sudan maintain their dynamics of hegemony in Nile Basin countries, Gulf States however are deploying proxy water diplomacy through investment in agricultural farmlands in Nile Basin countries. Increasing number of actors alter water access and security across formal and informal domains. The Nile Basin Cooperative Agreement (cfa) remains contested between upstream and downstream riparian states as being uncoordinated water management and development policies. Incorporating market and local users beyond the state gets politicized in securing water security. In view of this, this article hence suggests that power relations are not static, but subject to the changing circumstances. Egypt’s water security would be more sustainable when it engages cfa countries in a joint coordination and development projects.
Rectifying a Chronicle of Contradictions: The Political Context of Abraham Wheelock’s 1643 Anglo-Saxon Chronicle
Authors: Day Patrick V.
Published: June 2017

Abraham Wheelock’s first edition of theAnglo-Saxon Chronicleappeared at the height of the First English Civil War in 1643, and it is often treated by modern critics as an appendix to the Old EnglishHistoria Ecclesiasticato which it is attached. This paper argues that theChronicleparticipated in a larger royalist campaign to establish the West Saxons as the institutional forbears of the first two Stuart kings. The West Saxon genealogies authorize a seventeenth-century conception of patriarchal, divine kingship when they trace Alfred to the biblical Adam. Alternatively, the medievalChroniclepresents the advisory body of the Anglo-Saxons, thewitan,as a potentially restrictive force upon the monarchy—an image incompatible with a royalist agenda. Wheelock mediates the contradictory presence of the powerfulwitanby diminishing its historical importance through excision, substitution, and inconsistent translation so that theChroniclemay more easily conform to early modern perceptions of absolutist kingship.
Efficient dual-scale flow and thermo-chemo-rheological coupling simulation during on-line mixing resin transfer molding process
Authors: Imbert Mathieu , Abisset-Chavanne Emmanuelle , Comas-Cardona Sébastien , Prono David
Published: June 2017

Simulation tools are required to ease the determination of the optimal process parameters and injection strategy of short cycle resin transfer molding (RTM). The developed finite element method/volume of fluid numerical tool aims to simulate accurately and efficiently the flow of a reactive resin mixed on-line in a dual-scale porous reinforcement during the resin transfer molding process. A macroscopic mesh deals with the flow inside of the channels of the reinforcement while a representative microstructure associated to each element allows reproducing both the unsaturated area and the intra-tow resin storage. Degree of cure, temperature, and viscosity are updated and transported at each time step, both in the channels and in the tows of the fabric using advection equations and sink and source terms for inter-scale exchanges. A new flexible approach based on the textile’s geometry defines automatically the representative microstructure associated to each macroscopic element depending on its size and shape. Additionally, tow saturation is simplified under the assumption of high-speed injection to a sum of one-dimensional transverse tow saturation problems, which reduces the computational cost of the simulation. Convergence tests have highlighted the ability for the simulation tool to treat with an equivalent degree of accuracy a saturation problem with elements exhibiting element sizes three times smaller to three times bigger than the length of the unsaturated area. Significant computation time reductions have also been noticed when large elements were used. Finally thermo-chemo-rheological coupled simulations have been conducted, highlighting the importance of taking the dual-scale effect into account when simulating reactive injections with on-line mixing.
Improving Music Teaching through Interpersonal Relationships
Authors: Steele Royston Natalie
Published: June 2017

Interpersonal relationships are fundamental to learning and human development. To develop a positive and safe classroom environment with student motivation and learning, music educators need to learn to relate and connect effectively with others. This article looks at the importance of the interpersonal relationships in the classroom environment and provides tips for active teachers to improve these relationships and for preservice teachers to observe and reflect on during preparation. As music teachers, the manner in which we connect and relate to our students will teach them much about the art of music but also the art of being a compassionate and caring human being.
Investigating the effect of scale and scheduling strategies on the productivity of 3D managed print services
Authors: Gopsill James A , Hicks Ben J
Published: June 2017

Sales of extrusion 3D printers have seen a rapid growth and the market value is expected to triple over the next decade. This rapid growth can be attributed to a step change in capability and an increase in demand for 3D printed parts within mechanical, industrial and civil engineering processes. Correspondingly, a new technical prototyping platform – commonly referred to as Fabrication Laboratories – has emerged to provide a stimulus for local education, entrepreneurship, innovation and invention through the provision of on-demand 3D printing and prototyping services. Central to the effectiveness of the on-demand 3D printing and prototyping services – hereby referred to as 3D managed print services – is their ability to handle multiple users with varying knowledge and understanding of the manufacturing processes and scaling numbers of 3D printers in order to maximise productivity of the service. It is this challenge of productivity and more specifically the scalability and scheduling of prints that is considered in this article. The effect of scale and scheduling strategies on productivity is investigated through the modelling of four scheduling strategies for 3D managed print service of varying scales by altering the number of available printers and level of user demand. The two most common approaches (first-come first-serve and on-line continuous queue) and two alternatives based on bed space optimisation (first-fit decreasing height and first-fit decreasing height with a genetic algorithm) have been considered. Through Monte-Carlo simulation and comparison of the strategies, it is shown that increasing the scale of 3D managed print service improves the peak productivity and range of user demands at which the 3D managed print service remain productive. In addition, the alternative strategies are able to double the peak productivity of 3D managed print service as well as increase the user demand range where the 3D managed print service remains productive.
Augmented Lagrangian teaching–learning-based optimization for structural design
Authors: Li Hong-Shuang , Dong Qiao-Yue , Yuan Jiao-Yang
Published: June 2017

Stochastic optimization methods have been widely employed to find solutions to structural design optimization problems in the past two decades, especially for truss structures. The primary aim of this study is to introduce a design optimization method combining an augmented Lagrangian function and teaching–learning-based optimization for truss and nontruss structural design optimization. The augmented Lagrangian function serves as a constraint-handling tool in the proposed method and converts a constrained optimization problem into an unconstrained one. On the other hand, teaching–learning-based optimization is employed to resolve the transformed, unconstrained optimization problems. Since the proper values of the Lagrangian multipliers and penalty factors are unknown in advance, the proposed method is implemented in an iterative way to avoid the issue of selecting them, i.e. the Lagrangian multipliers and penalty factors are automatically updated according to the violation level of all constraints. To examine the performance of the proposed method, it is applied on a group of benchmark truss optimization problems and a group of nontruss optimization problems of aircraft wing structures. The computational results obtained by the proposed method are compared to the results produced by both other version of teaching–learning-based optimization and stochastic optimization methods.
Comparative efficacy and safety of intravenous or subcutaneous belimumab in combination with standard therapy in patients with active systemic lupus erythematosus: a Bayesian network meta-analysis of randomized controlled trials
Authors: Lee Y H , Song G G
Published: June 2017

Objective

In this study, we aimed to assess the relative efficacy and safety of intravenous (IV) or subcutaneous (SC) belimumab compared with those of placebo in patients with active systemic lupus erythematosus (SLE).

Methods

We performed a Bayesian network meta-analysis to combine the direct and indirect evidence from randomized controlled trials (RCTs) examining the efficacy and safety of belimumab 1 mg/kg and 10 mg/kg IV administration, and belimumab 200 mg SC injection, and placebo in patients with active SLE despite having received standard therapy.

Results

Five RCTs (3460 patients) met the inclusion criteria. The SLE Responder Index (SRI) response rate at week 52 was significantly higher in the belimumab 10 mg/kg group than in the placebo group (OR 2.63, 95% CrI 2.14–3.23). Similarly, the SRI response rates were significantly higher in the belimumab 1 mg/kg, and belimumab 200 mg SC groups than in the placebo group (OR 2.42, 95% CrI 1.90–3.09; OR 1.71, 95% CrI 1.27–2.29). Ranking probability based on surface under the cumulative ranking curve (SUCRA) indicated that belimumab 10 mg/kg had the highest probability of being the best treatment for achieving the SRI response (SUCRA = 0.9174), followed by belimumab 1 mg/kg (SUCRA = 0.7338), belimumab 200 mg SC (SUCRA = 0.3487), and placebo (SUCRA = 0.0000). However, a sensitivity test by omitting one outlier study showing low SRI response rate compared with the other three studies (11% vs. 33%, 40%, 48%) showed that belimumab 200 mg SC and belimumab 10 mg/kg had the highest probability of being the best treatment for achieving the SRI response (SUCRA = 0.7903, SUCRA = 0.7456), followed by belimumab 1 mg/kg, and placebo. The number of serious adverse events (SAEs) did not differ significantly among the four treatment options.

Conclusions

Belimumab at 1 and 10 mg/kg IV and belimumab 200 mg SC in combination with standard therapy was an efficacious intervention for active SLE, and was not associated with a significant risk of SAEs.
Beyond Hospital Discharge Mechanics: Managing the Discharge Paradox and Bridging the Care Chasm
Authors: Canary Heather E. , Wilkins Victoria
Published: June 2017

Hospital discharge processes are complex and confusing, and can detrimentally affect patients, families, and providers. This qualitative study investigated pediatric hospital discharge experiences from the perspectives of parents of children with acute and chronic health conditions, primary care providers, and hospitalists. Focus groups and interviews with parents, primary care providers, and hospitalists were used to explore discharge experiences and ideas for improvement offered by participants. Using an iterative approach to analyze data resulted in five major themes for discharge experiences: (a) discharge problems, (b) teamwork, (c) ideal discharge, (d) care chasm, and (e) discharge paradox. The first three themes concern practical issues, whereas the last two themes reflect negative emotional experiences as well as practical problems encountered in the discharge process. Improvements in communication were viewed as a primary strategy for improving the discharge process for better outcomes for patients, their families, and providers.
Relationship breakup disclosures and media ideologies on Facebook
Authors: Haimson Oliver L , Andalibi Nazanin , De Choudhury Munmun , Hayes Gillian R
Published: June 2017

After relationship breakups, people must make difficult decisions about whether and how to convey this change in a networked environment. To understand and characterize behaviors around breakup disclosures, we analyzed survey responses from 119 US Facebook users who reported experiencing a recent breakup. Using mixed methods, we find that those perceiving Facebook as a more efficient disclosure medium are more likely to announce breakups. We show how media ideologies around Facebook breakup disclosures vary; yet people assume others hold similar beliefs about what is appropriate. We contribute to self-disclosure and online identity literature by identifying two new ways people engage in disclosure and self-presentation on social media: announcements, which highlight how social media can serve as efficient one-to-many disclosure sources, and private status change behaviors, a reflexive means of self-presentation. Understanding breakup disclosures provides insight into designing social media to better enable users to find support during difficult life transitions.
The optimum colour temperature for illumination of Japanese-style gardens in summer and winter
Authors: Jia D , Misawa T , Takamatsu M , Hirobayashi S
Published: June 2017

Japanese-style gardens offer a wealth of spiritual and cultural value. In this study, we attempt to determine the optimum colour temperature for lighting Japanese-style gardens at night. We analyse the influence of a change in light source colour temperature on image recognition using digitalization and quantification with the semantic differential technique. In addition, we propose a new evaluation methodology for the semantic differential technique and examine the statistical significance of the results. We find that in summer, impressions of the optimum colour temperature for each element (vegetation, water, stone and structure) differ significantly, but in winter, because of the effects of snow, differences in the impression of each colour temperature are not as distinct. Moreover, the colour of the natural environment or overall season affects peoples’ preferred light source colour temperature.
Early risk of recurrent stroke in patients with symptomatic carotid near-occlusion: Results from CAOS, a multicenter registry study
Authors: García-Pastor Andrés , Gil-Núñez Antonio , Ramírez-Moreno José María , González-Nafría Noelia , Tejada Javier , Moniche Francisco , Portilla-Cuenca Juan Carlos , Martínez-Sánchez Patricia , Fuentes Blanca , Gamero-García Miguel Ángel , Alonso de Leciñana María , Cánovas-Verge David , Aladro Yolanda , Parkhutik Vera , Lago-Martín Aida , de Arce-Borda Ana María , Usero-Ruíz María , Delgado-Mederos Raquel , Pampliega Ana , Ximenez-Carrillo Álvaro , Bártulos-Iglesias Mónica , Castro-Reyes Enrique
Published: June 2017

Background

The risk of recurrent stroke among patients with symptomatic carotid near-occlusion is not well established, and management of the condition remains controversial. Symptomatic carotid near-occlusion with full collapse has been identified as a strong predictor of early recurrence. We aimed to analyze the 90-day risk of recurrent ipsilateral ischemic stroke in medically treated patients with symptomatic carotid near-occlusion.

Methods

We performed a multicenter, nationwide, prospective study from January 2010 to May 2016. Patients with angiography-confirmed symptomatic carotid near-occlusion were included. The primary endpoint was ipsilateral ischemic stroke or transient ischemic attack (TIA) within 90 days after the presenting event. For this analysis, patients who underwent revascularization within 90 days after stroke were excluded.

Results

The study population comprised 141 patients from 17 Spanish centers; 83 patients were treated medically. Primary endpoint occurred in eight patients, resulting in a cumulative rate of 10.6% (95% CI, 3.7–17.5). Previous history of stroke or transient ischemic attack was identified as an independent predictor for recurrence in the multivariate Cox regression analysis (HR, 4.37 [95% CI, 1.05–18.18]; p = 0.043), while the presence of full collapse was not associated with an increased risk (HR, 0.81 [95% CI, 0.17–3.92]; p = 0.793). The risk of recurrence was also not affected by the presence of significant stenosis or occlusion of the contralateral carotid artery, or by the collateral circulation.

Conclusions

Patients with symptomatic carotid near-occlusion seem to have an increased risk of early ipsilateral recurrent stroke. Our results contrast with the low risk of symptomatic carotid near-occlusion reported to date. Full collapse did not increase the risk of recurrent stroke in our study.
Rethinking relationships with curriculum by engaging with foxes and sharing stories in early childhood spaces
Authors: Rowan Mary Caroline
Published: June 2017

Nunangat pedagogies concern the adoption of teaching practices informed by relationships with land, water and ice. In this article, the researcher examines an opportunity to disrupt Global North dominance in the Inuit homeland through engagements with fox. Nunangat methodologies require consultations with Elders and hunters especially concerning knowledge that is not accessible via the Internet or at the library. A rhizomatic analysis is used to connect the presentation of the various research narratives and analysis of encounters with fox. These strategies are employed to facilitate occasions to re-conceptualize early childhood practices in ways which enable recognition of the vitality and viability of local Indigenous ways of knowing and being.
Prevalence and outcome of patients with cancer and acute coronary syndrome undergoing percutaneous coronary intervention: a BleeMACS substudy
Authors: Iannaccone Mario , D’Ascenzo Fabrizio , Vadalà Paolo , Wilton Stephen B , Noussan Patrizia , Colombo Francesco , Raposeiras Roubín Sergio , Abu Assi Emad , González-Juanatey José Ramón , Simao Henriques Jose Paulo , Saucedo Jorge , Kikkert Wouter J , Nuñez-Gil Iván , Ariza-Sole Albert , Song Xian-tao , Alexopoulos Dimitrios , Liebetrau Christoph , Kawaji Tetsuma , Moretti Claudio , Garbo Roberto , Huczek Zenon , Nie Shao-Ping , Fujii Toshiharu , Correia Luis CL , Kawashiri Masa-aki , García Acuña José María , Southern Danielle , Alfonso Emilio , Terol Belén , Garay Alberto , Zhang Dongfeng , Chen Yalei , Xanthopoulou Ioanna , Osman Neriman , Möllmann Helge , Shiomi Hiroki , Giordana Francesca , Kowara Michal , Filipiak Krzysztof , Wang Xiao , Yan Yan , Fan Jing-Yao , Ikari Yuji , Nakahashi Takuya , Sakata Kenji , Gaita Fiorenzo , Yamagishi Masakazu , Kalpak Oliver , Kedev Sasko
Published: June 2017

Background:

The prevalence and outcome of patients with cancer that experience acute coronary syndrome (ACS) have to be determined.

Methods and results:

The BleeMACS project is a multicentre observational registry enrolling patients with acute coronary syndrome undergoing percutaneous coronary intervention worldwide in 15 hospitals. The primary endpoint was a composite event of death and re-infarction after one year of follow-up. Bleedings were the secondary endpoint. 15,401 patients were enrolled, 926 (6.4%) in the cancer group and 14,475 (93.6%) in the group of patients without cancer. Patients with cancer were older (70.8±10.3 vs. 62.8±12.1 years, P<0.001) with more severe comorbidities and presented more frequently with non-ST-segment elevation myocardial infarction compared with patients without cancer. After one year, patients with cancer more often experienced the composite endpoint (15.2% vs. 5.3%, P<0.001) and bleedings (6.5% vs. 3%, P<0.001). At multiple regression analysis the presence of cancer was the strongest independent predictor for the primary endpoint (hazard ratio (HR) 2.1, 1.8–2.5, P<0.001) and bleedings (HR 1.5, 1.1–2.1, P=0.015). Despite patients with cancer generally being undertreated, beta-blockers (relative risk (RR) 0.6, 0.4–0.9, P=0.05), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (RR 0.5, 0.3–0.8, P=0.02), statins (RR 0.3, 0.2–0.5, P<0.001) and dual antiplatelet therapy (RR 0.5, 0.3–0.9, P=0.05) were shown to be protective factors, while proton pump inhibitors (RR 1, 0.6–1.5, P=0.9) were neutral.

Conclusion:

Cancer has a non-negligible prevalence in patients with acute coronary syndrome undergoing percutaneous coronary intervention, with a major risk of cardiovascular events and bleedings. Moreover, these patients are often undertreated from clinical despite medical therapy seems to be protective. Registration:The BleeMACS project (NCT02466854).
Women’s Autonomy and Control to Exercise Reproductive Rights: A Sociological Study from Rural Bangladesh
Authors: Biswas Amit Kumar , Shovo Taufiq-E-Ahmed , Aich Moutithi , Mondal Sykat
Published: June 2017

Women’s autonomy is a potentially noteworthy but less studied indicator of women’s control to exercise reproductive rights in a patriarchal country such as Bangladesh. The study is a sociological investigation that examined whether women’s autonomy matters or not in determining their control to exercise reproductive rights in rural Bangladesh. A survey was conducted on 200 randomly selected married women from Hogladanga village in the Bagerhat district of Bangladesh. We administered an interview questionnaire containing 27 Likert-type questions under three mutually interlinked domains for autonomy measures and 12 Likert-type questions under two mutually interlinked domains for reproductive rights status measures. The findings revealed that women’s autonomy status is strongly associated with their control to exercise reproductive rights status (β = .862, p < .001) along with both of the proxy variables, that is, sexual behavior index (β = .915, p < .001) and reproductive behavior index (β = .62, p < .001). The study findings suggest that women’s autonomy must be considered an important sociocultural determinant of higher control to exercise reproductive rights for young mothers in Bangladesh.
Cancer mortality in patients with schizophrenia: systematic review and meta-analysis
Authors: Zhuo Chuanjun , Tao Ran , Jiang Ronghuan , Lin Xiaodong , Shao Mingjing
Published: June 2017

Background

Previous studies have reported conflicting results on the association between schizophrenia and cancer mortality.

Aims

To summarise available evidence and quantify the association between schizophrenia and cancer mortality using meta-analysis.

Method

We systematically searched literature in the PubMed and Embase databases. Risk estimates and 95% confidence intervals reported in individual studies were pooled using the DerSimonian–Laird random-effects model.

Results

We included 19 studies in the meta-analysis. Among them, 15 studies reported standardised mortality ratios (SMRs) comparing patients with schizophrenia with the general population, and the pooled SMR was 1.40 (95% CI 1.29–1.52, P<0.001). The other four studies reported hazard ratios (HRs) comparing individuals with schizophrenia with those without schizophrenia; the pooled HR was 1.51 (95% CI 1.13–2.03, P = 0.006).

Conclusions

Patients with schizophrenia are at a significantly increased risk of cancer mortality compared with the general population or individuals without schizophrenia.
RBM24 promotes U1 snRNP recognition of the mutated 5′ splice site in theIKBKAPgene of familial dysautonomia
Authors: Ohe Kenji , Yoshida Mayumi , Nakano-Kobayashi Akiko , Hosokawa Motoyasu , Sako Yukiya , Sakuma Maki , Okuno Yukiko , Usui Tomomi , Ninomiya Kensuke , Nojima Takayuki , Kataoka Naoyuki , Hagiwara Masatoshi
Published: June 2017

The 5′ splice site mutation (IVS20+6T>C) of theinhibitor of κ light polypeptide gene enhancer in B cells, kinase complex-associated protein(IKBKAP) gene in familial dysautonomia (FD) is at the sixth intronic nucleotide of the 5′ splice site. It is known to weaken U1 snRNP recognition and result in an aberrantly spliced mRNA product in neuronal tissue, but normally spliced mRNA in other tissues. Aberrantly splicedIKBKAPmRNA abrogates IKK complex-associated protein (IKAP)/elongator protein 1 (ELP1) expression and results in a defect of neuronal cell development in FD. To elucidate the tissue-dependent regulatory mechanism, we screened an expression library of major RNA-binding proteins (RBPs) with our mammalian dual-color splicing reporter system and identified RBM24 as a regulator. RBM24 functioned as a cryptic intronic splicing enhancer binding to an element (IVS20+13–29) downstream from the intronic 5′ splice site mutation in theIKBKAPgene and promoted U1 snRNP recognition only to the mutated 5′ splice site (and not the wild-type 5′ splice site). Our results show that tissue-specific expression of RBM24 can explain the neuron-specific aberrant splicing ofIKBKAPexon 20 in familial dysautonomia, and that ectopic expression of RBM24 in neuronal tissue could be a novel therapeutic target of the disease.
Πού έκειτο η παλαιά Θέρμη
Authors: Ρωμαίος Κ. Α.
Published: June 2017

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Δύο Πατριαρχικά Σιγίλλια Διονυσίου του Δ' και Γρηγορίου του Ε'
Authors: Δελιάλης Νικ. Π.
Published: June 2017

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Νικολάου Πατριάρχου ομιλία εις την άλωσιν της Θεσοαλονίκης
Authors: Τσάρας Γιάννης
Published: June 2017

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Χρονικά Αρχαιολογικά
Authors: Μακαρόνας Χ. Ι.
Published: June 2017

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Κώδιξ Σχολείων Κοινότητος Κλεισούρας
Authors: Σ. Α.
Published: June 2017

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Λαογραφικά από την Κατερίνην
Authors: Γιαννακογεώργος Α.
Published: June 2017

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Που έκειτο η αρχαία πόλις Ελίμεια
Authors: Κανατσούλης Δ.
Published: June 2017

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Το Σιατιστινό ιδίωμα
Authors: Τσοπανάκης Αγαπητός Γ.
Published: June 2017

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Βυζαντιναί μελέται VII: ο Μομτσίλος και το κράτος του
Authors: Κυριακίδης Στίλπων Π.
Published: June 2017

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Σύμμεικτα λαογραφικά εκ Ρουμλουκιού
Authors: Παπαθανασίου Θ.
Published: June 2017

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Περί κιβωρίων των ναών του Αγίου Δημητρίου Θεσσαλονίκης και Κωνσταντινουπόλεως
Authors: Θεοτοκά Ναυσικά
Published: June 2017

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Η Θεσσαλονίκη κατά τας αρχάς της Ελληνικής Επαναστάσεως
Authors: Σούλης Γεώργιος Χρ.
Published: June 2017

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Paul Lemerle, Actes de Kutlumus. Edition diplomatique. Ouvrage honoré d' une souscription de 1' Académie des Inscriptions et Belles - Lettres. Texte. Archives de Γ Athos publiées sons la direction de Gabriel Millet, membre de Γ Institut. II. Paris 1945.
Authors: Κυριακίδης Στίλπων Π.
Published: June 2017

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Fr. Dölger, Aus den Schatzkammern des Heiligen Berges. 115 Urkunden und 50 Urkundensiegel aus 10 Jahrhunderten. Im Auftrage und mit Unterstützungder Bayerischen Akademie der Wissenschaften. Textband. Münchner Verlag (Bisher F. Bruckmann), [194ö].
Authors: Κυριακίδης Στίλπων Π.
Published: June 2017

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Ιουλίου Moravcsik, Ελληνικόν ποίημα περί της μάχης της Βάρνης. «Ούγγροελληνικαί Μελέται» αριθ. 1. Budapest, 1935. Σελ. 56.
Authors: Τζιάτζιος Ευάγγ. Στ.
Published: June 2017

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Ν. Κ. Λιούμηα, Η αναγκαία στρατηγική διαρρύθμισις των ελληνικών συνόρων. [Εταιρεία Μακεδονικών Σπουδών. Εθνική βιβλιοθήκη αρ. 6]. Θεσσαλονίκη, 1946. 8ον σ. 15.
Authors: Κόλιας Γ. Τ.
Published: June 2017

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