bluuebunny/crossref_metadata_2025 huggingface dataset:
Explorando o legado de Carlos Alberto Cerqueira Lemos: uma análise da obra “O que é patrimônio histórico”
Authors: Dutra Patrick , Albonico Hugo da Silva , Cardoso Jaqueline da Silva
Published: October 2024

O Que é Patrimônio Histórico" de Carlos Alberto Cerqueira Lemos oferece uma visão abrangente e multidisciplinar sobre a preservação do patrimônio cultural brasileiro. Ao explorar aspectos como a natureza do patrimônio cultural, a importância da preservação, os desafios enfrentados e os marcos legais relevantes, Lemos apresenta uma análise detalhada que vai além das questões técnicas e históricas, adentrando também em debates contemporâneos sobre identidade nacional, desigualdade social e influências externas. Sua obra não apenas educa sobre a diversidade e importância do patrimônio cultural brasileiro, mas também destaca a necessidade contínua de conscientização e ação para sua preservação em meio às transformações sociais, políticas e econômicas do país.
Core, Clinical and Ethical Competences of Dietitians/Nutritionists in Palliative Care
Authors:   Instituto de Bioética da  Universidade Católica  Portuguesa,  Rua Diogo Botelho, n.º 1327,  4169-005 Porto, Portugal, Pinho-Reis Cíntia ,   Unidade de Cuidados  Continuados da Fundação  Fernando Pessoa, Rede  Nacional de Cuidados  Continuados Integrados,  Avenida Fernando Pessoa,  n.º 150, 4420-096 Gondomar,  Portugal,   Hospital-Escola da  Universidade Fernando  Pessoa,  Avenida Fernando Pessoa,  n.º 150, 4420-096 Gondomar,  Portugal, Sarmento António ,   Departamento de  Doenças Infecciosas,  Centro Hospitalar e  Universitário de São João,  Alameda Prof. Hernâni  Monteiro,  4200-319 Porto, Portugal,   Faculdade de Medicina  da Universidade do Porto,  Alameda Prof. Hernâni  Monteiro,  4200-319 Porto, Portugal, Capelas Manuel Luís ,   Instituto de Ciências da  Saúde da Universidade  Católica Portuguesa,  Lisboa,  Palma de Cima, 1649-023 Lisboa, Portugal,   Centro de Investigação  Interdisciplinar em Saúde  do Instituto de Ciências  da Saúde da Universidade  Católica Portuguesa,  Lisboa,  Palma de Cima, 1649-023 Lisboa, Portugal
Published: October 2024

INTRODUCTION: Dietitians/nutritionists ́ professional competences in Palliative Care have been poorly investigated. Thus, to dietitians/nutritionists develop their jobs with scientific and technical rigour based on an ethical point of view it is necessary that they have their professional competences very well defined. OBJECTIVES: To identify a set of professional competences of dietitians/nutritionists in the field of Palliative Care. METHODOLOGY: Systematic literature review in Pubmed, CINAHL, Academic Search Complete, and Web of Science. RESULTS: A set of 32 publications were found and analysed. From these publications the competence were identified and grouped in the following dominions: 13 core competences, 30 clinical competences, 18 ethical competences. CONCLUSIONS: Dietitians/nutritionists are the professionals who aggregates knowledge and expands the technical competences of nutritional care and support in Palliative Care.
Inovação na Rotulagem – Como Comunicar a Sustentabilidade
Authors:   Egas Moniz School of  Health & Science,  Campus Universitário,  Quinta da Granja, 2829-511 Caparica,  Portugal, Alves Carlota , Delgado Mayumi Thaís ,   Sonae MC,  Estrada da Outurela,  n.º 118, Edifício Imopolis  Bloco D,  2790-114 Carnaxide,  Portugal
Published: October 2024

A insustentabilidade dos sistemas agroalimentares tem levado ao esgotamento dos recursos do nosso planeta. O Pacto Ecológico Europeu, proposto pela Comissão Europeia, concomitantemente com a Estratégia Do Prado ao Prato, estabeleceram já metas para a transição ecológica. Alinhados com estas propostas surgem, na indústria alimentar, projetos de sistemas de rotulagem ambiental cujo objetivo é comunicar a sustentabilidade, perante a sociedade de consumo, contribuindo para a consciencialização do impacto ambiental dos produtos no mercado. O presente estudo aborda um tema relevante e atual: visa avaliar dois recentes e promissores sistemas de rotulagem ambiental – Eco-Score e Planet-Score –, estudando a sua viabilidade e aplicabilidade na indústria alimentar, considerando as metodologias utilizadas, os desafios da sua implementação e o impacto nas escolhas dos consumidores. Após o levantamento das propostas legislativas, documentos e pareceres governamentais europeus relativos à temática da sustentabilidade, no portal da Comissão Europeia, foi desenvolvida uma análise criteriosa dos dois sistemas de rotulagem e metodologias da avaliação do desempenho ambiental (Análise do Ciclo de Vida, método PEF e bases de dados), através da consulta direta de informação nas páginas oficiais destes sistemas de rotulagem e ainda de relatórios, documentos e artigos publicados por entidades e especialistas que estudam a sustentabilidade dos sistemas alimentares. Foi ainda analisada a relação do ecolabelling com as escolhas dos consumidores. Apesar das limitações quer a nível de desarmonização legal, quer a nível do rigor científico das metodologias de cálculo do impacto ecológico, sujeitas ainda a revisão e melhoria, o cenário de transição para um mundo mais verde, pela criação destes sistemas de rotulagem, mostra-se bastante otimista.
Análise da rotulagem de suplementos alimentares para perda de peso e potencial impacto dos seus ingredientes na saúde dos consumidores
Authors:   Escola Superior de  Saúde de Leiria do Instituto  Politécnico de Leiria,  Campus 2 - Morro do  Lena, Alto do Vieiro -  Apartado 4137,  2411-901 Leiria, Portugal, Martins Márcia , Jorge Rui ,   Escola Superior de  Saúde de Leiria do Instituto  Politécnico de Leiria,  Campus 2 - Morro do  Lena, Alto do Vieiro -  Apartado 4137,  2411-901 Leiria, Portugal,   Center for Innovative  Care and Health  Technology (ciTechCare),  Hub de Inovação de Saúde  do Politécnico de Leiria,  Campus 5, R. das  Olhalvas,  2414-016 Leiria, Portugal,   Escola Superior de  Desporto de Rio Maior do  Instituto Politécnico de  Santarém,  Av. Dr. Mário Soares,  n.º 110,  2040-413 Rio Maior,  Portugal
Published: October 2024

INTRODUÇÃO: Apesar da evidência científica disponível não mostrar utilidade clínica na utilização da maioria dos suplementos alimentares que visam o emagrecimento e destes frequentemente apresentarem problemas do ponto de vista de qualidade e segurança, os suplementos alimentares continuam a ser comercializados e utilizados por quem procura perder peso. OBJETIVOS: Analisar a rotulagem de suplementos alimentares direcionados à perda de peso comercializados em Portugal, quanto a potenciais riscos relacionados com os ingredientes que os compõem e avaliar com base na literatura científica disponível o benefício na perda de peso dessas substâncias. METODOLOGIA: Recolheram-se aleatoriamente, em supermercados de Lisboa, entre março e abril de 2023, 40 suplementos alimentares que na sua embalagem visam especificamente a perda de peso, tendo sido feita uma análise à sua rotulagem. RESULTADOS: As substâncias mais comummente encontradas, na maioria dos casos combinadas, e em dosagens muito variáveis, foram o picolinato de crómio, a Cynara scolymus L., o Taraxacum officinale, a Camellia sinensis, o Citrus aurantium, o Silybum marianum e a Garcinia cambogia. Identificaram-se alegações de saúde infundadas e as substâncias identificadas ou não possuem ensaios clínicos aleatorizados e controlados sobre o seu impacto na perda de peso, ou quando possuem, o benefício demostrado é diminuto ou inexistente, apresentando ainda alguns riscos do ponto de vista de segurança. CONCLUSÕES: Os suplementos alimentares que visam a perda de peso apresentam uma grande diversidade de substâncias em diferentes combinações e dosagens, que para além de não apresentarem robustez na evidência do seu benefício como auxílio no tratamento da obesidade, podem apresentar potenciais riscos para quem os consome.
Sex and Gender Considerations in Orthopaedic Research
Authors: Bechtold Joan E. , Bauer Thomas W. , Clayton Janine , Foucher Kharma C. , Graves Leland , Heidari Shirin , Ireland Mary , Losina Elena , Paul Caroline R. , Ramos Paula S. , Regensteiner Judith G. , Schiebinger Londa , Templeton Kimberly , Temkin Sarah
Published: October 2024

JBJS convened a symposium to discuss the reporting of sex and gender in research studies as an imperative to improve research methods and results to benefit all patients. Barriers to improved reporting include a lack of societal and cultural acceptance of its need; a lack of education regarding appropriate terminology and appropriate statistical methods and efficient study designs; a need for increased research funding to support larger group sizes; unknown concordance of cell and animal models with humans to reflect biologic variables such as sex; and a lack of understanding of key considerations of gender, race, and other social determinants of health and how these factors intersect. Attention to developing and disseminating best-practice statistical methods and to educating investigators (at all career levels), reviewers, funders, editors, and staff in their proper implementation will aid reporting. Concomitantly, well-designed studies with sufficient rigor and adequate resources are essential to enable meaningful and reproducible research. Existing recommendations, such as the Sex and Gender Equity in Research (SAGER) guidelines, provide valuable guidance that can be applied across the research ecosystem. Academic institutions and private foundations are likely groups to assist in scientific and institutional review board guidance and study recruitment and pilot funding to generate meaningful power estimates, and to serve as sources for additional funding and presentation of workshops, educational events, and seminars. All of this needs to be conducted on an ongoing basis to ensure that sex and gender are considered in scientific analyses, where relevant.
Identifying sustainability and resilience investments to implement the 2022 US Army Climate Strategy : fiscal year 2023 sustainable design and development update
Authors: Stidwell Samuel , Panozzo Brent , Stumpf Annette , Fuhler Megan , Young Allison , Carroll Liam , Ward Jeffrey
Published: October 2024

This report offers a detailed assessment of the US Army’s adherence to sustainable design and development (SDD) policies, encompassing the US Army Sustainable Design and Development (SDD) Policy memorandum; Unified Facilities Criteria (UFC) 1-200-02, High Performance and Sustainable Building Requirements; Executive Orders 14,008 and 14,057; the Army Climate Strategy; and required LEED v4 certifications. The evaluation comprises five primary tasks, including quarterly reports on US Army military construction (MILCON) project LEED v4 certifications, analysis of US Army LEED v4 certifications and trends, research and implementation of the intermediate objectives in the 2022 US Army Climate Strategy focusing on strategies to achieve climate goals, an analysis explaining the advantages of Performance Excellence in Electricity Renewal (PEER) certification for Army microgrids, and industry knowledge gained from participation in the Greenbuild 2022 conference. Key recommendations developed in this assessment include enhancing transparency in LEED reporting, considering PEER certification, expediting climate strategy implementation, and active participation in industry gatherings. This report serves as a comprehensive resource for informed decision-making, aiding the US Army in advancing its sustainable design and development initiatives to meet future environmental and sustainability objectives.
Immobilization of Vibrio cholerae S1 (NAG) L-Glutaminase on Different Supports
Authors: Hassan Shatha Salman
Published: October 2024

تـــــم الحصـول عـــــلـــى ست عشرة عزلة لبكتريا Vibrio  منتجة لانزيم الكلوتامينيز     (L-glutaminase) من نماذج سريرية ومياه ، وانتخبت عزلة واحدة اعتماداً على انتاجيتها الاعلى للانزيم ، وشخصت على انها Vibrio cholerae (NAG) واعطي لها الرمز S1.
نميت البكتريا في وسط سائل (يحتوي على الكلوتامين) ، واستخلص الانزيم من الخلايا بعد تكسيرها بالموجات فوق الصوتية.
ورسب الانزيم باستعمال كبريتات الامونيوم بنسبة اشباع 30% ، وتمت ديلزته ، ثم قيد بامتزازه على مواد ساندة مختلفة تضمنت السيفادكس (Sephadex G-100) ، ومسحوق السليلوز ، والنشا ، وهلام السليكا ، والخرز الزجاجية ، والفحم.
بينت النتائج ان Sephadex G-100 يحتفظ بمعظم فعالية الانزيم (90 %) يعقبه النشا (78 %) ثم هلام السليكا والسليلوز (71 %) بينما أحتفظ الفحم والخرز الزجاجية بـ 58 % فقط من فعالية الانزيم.
تم تعريض الانزيم المقيد والحر لدرجات حرارية وقيم رقم هيدروجيني مختلفة ، ولوحظ ان الانزيم المقيد اكثر ثباتاً من الانزيم الحر في درجات الحرارة المختلفة وقيم الرقم الهايدروجيني ، واظهر هلام السليكا حماية جيدة للانزيم في درجات الحرارة العالية إذ بقي محتفظاً بـ 54 % و      22 % من الفعالية الاصلية عند تعريضه لدرجة 50 و 60م لمدة ساعتين على التوالي في حين احتفظ الانزيم الحر بـ 30 % و 10 % في هاتين الدرجتين.
لوحظ ان الانزيم المقيد اكثر ثباتاً برقم هايدروجيني 7 مما عليه برقم 4 او 10 واحتفظ الانزيم المقيد بالسيفادكس (Sephadex G-100) باعلى نسبة فعالية (98 %) عند الرقم الهايدروجيني 7 لمدة ساعتين بينما احتفظ الانزيم الحر بـ 73 % في الظروف نفسها. وعندما حفظ الانزيم المقيد بدرجة 4م لمدة شهر بقي محتفظاً بـ 35 % من فعاليته قياساً بالانزيم الحر الذي احتفظ بـ 18 %.
من هذه النتائج يتبين ان انزيم الكلوتامينيز المنتج من بكتريا V. cholerae S1 يمكن تقييده بطريقة الامتزاز على مواد مختلفة ، وان Sephadex G-100  مادة ملائمة لتقييده والحفاظ على فعالية عالية ، وان هلام السليكا يحمي الانزيم من الحرارة العالية بشكل افضل من غيره والانزيم المقيد عموماً اكثر ثباتاً من الانزيم الحر في درجات الحرارة وقيم الرقم الهيدروجيني المختلفة فضلاً عن ثباته الخزني.
Electronic stopping power correction for different phase shift conditions
Authors: Hussien Abeer Ali Mohamad , Mohammed Dalya Abd Ali
Published: October 2024

يعتبر تصحيح بلوخ ( Bloch correction) من التصحيحات المهمة لقدرة الإيقاف (Stopping power) لكونه يربط الوصف الكلاسيكي للعالم بور(Bohr) مع المعالجة الكمية للعالم بيتا(Bethe).
      تم في هذا البحث إجراء دراسة حول اعتماد تصحيح بلوخ على فرق الطور و لمديات مختلفة من طاقة الجسيم, و تبين إن تصحيح بلوخ في حالتيه النسبية(γ=Ε⁄mc²→0) واللانسبية(γ→1) يعتمد على فرق الطور و طاقة الجسيم (γ) و لكن في الحالة الفوق نسبية لتصحيح بلوخ (∞ →γ) يعتمد على فرق الطور فقط .
وتم حساب قدرة الإيقاف الالكترونية في السرع الواطئة بدلالة فرق الطور.
Tradition of Venerating the Lotus Sūtra in the 11th Century in Japan According to Hokke genki
Authors:   Russian Presidential Academy of National Economy and Public Administration, Trubnikova Nadezhda
Published: October 2024

“Notes on the Miracles of the Lotus Sūtra in the Great Country of Japan” (Daini­honkoku Hokkekyō genki, briefly Hokke genki, 1040s) builds a picture of the ve­neration of the sūtra in Japanese monastic and lay circles from individual stories. It is the stories from Hokke genki that usually represent the devotees of the Lotus Sūtra in later monuments. In the sūtra its adherents find a single meaning for all the various instructions that the Buddha has ever given. The biographies of fa­mous teachers of the 7th–11th centuries are followed by stories of ordinary monks, as well as novices, nuns, laymen and laywomen, animals and gods. Among the outstanding monks there are founders of the Tendai school, descen­dants of noble families who were trained in it, as well as preachers, scribes and miracle workers of less noble origin; they all strive for solitude, following the words of the sūtra, but their works are aimed at benefiting people and all suf­fering beings. The narrator describes different ways of working with the canoni­cal text (reading, copying, preaching) and shows what other traditions could be used in 11th-century Japan combined with the veneration of the Lotus Sūtra: first of all, it is belief in the Pure Land and rituals based on the applied teaching mikkyō. Wise ascetics read and copy the sūtra in meditative concentration, identi­fying with its characters, but an ordinary person also becomes like the Buddha when they make sure that as many inhabitants of the world of suffering as possi­ble learn about the sūtra
Demon or Buddha: Ryōgen and His Image in The Setsuwa Tales of “Kojidan”
Authors:   Russian Presidential Academy of National Economy and Public Administration, Kolyada Maria
Published: October 2024

In the paper biography of Ryōgen, a prominent Japanese monk of the 10th cen­tury and Tendai zasu, is considered, as well as his contribution in the develop­ment of Tendai school is briefly discussed. Also, the analysis of Ryōgen’s achievements and vices as the authors of setsuwa tales’ compilations saw them is presented, based mainly on the “Tales About Old Matters” (“Kojidan”, early 13th century) by Minamoto no Akikane. Akikane chose for the chapter about monks three stories in which Ryōgen plays a significant role. The author creates an image of zasu as a superhuman being, dragon, who was born in the human world and became the head of Tendai school for the benefit of others only. In the literature of Akikane’s and slightly latter time there were examples of completely opposite views on Ryōgen’s nature and his deeds too. Such differ­ence in understanding of the zasu image in Japanese culture is accounted for the facts of his biography. With the lack of advantage of being highborn or rich, he overcame many obstacles and climbed on the very top of monastic hierarchy, particularly due to his exceptional eloquence, knowledge of Buddhist texts and ability to make connections with lay aristocracy. He was criticized for the latter, but in fact he successfully took Tendai school out of stagnation and led it to prosperity. He played his role in formation of schism in the school because he re­garded with favour monks of his own linage, but he also was a talented adminis­trator, built temples, improved education in Enryakuji. He influenced on develop­ment of Amidaism, and his disciples became prominent religious figures. That may be the cause why Akikane condemns ambitious monks, but not Ryōgen
The Ideas of Cosmism as a Philosophical Foundation for Evolutionary-Ecological Thinking (Reflections on the Book)
Authors:   Institute of Philosophy, Russian Academy of Sciences, Ilin Aleksander ,   M.K. Ammosov North-Eastern Federal University
Published: October 2024

Evolutionary-ecological thinking, in contemporary conditions, is a relevant di­rection in the synthesis of evolutionism and ecology. The ideas of wholeness, organicism, and historicity, which form the core of the reflections of the main representatives of the philosophy of Russian cosmism, largely set the world­view tone for this direction. These ideas are becoming increasingly relevant in modern conditions, where space exploration presents itself as a global prob­lem related to overcoming the negative consequences of the ecological crisis. The author’s focus is on the collective monograph Russian Cosmism: N.F. Fe­dorov, K.E. Tsiolkovsky, V.I. Vernadsky, A.L. Chizhevsky, published in the series Russian Philosophy of the First Half of the XXth Century, whose authors dis­cuss the worldview and methodological specifics of the concepts of Russian cosmists in the context of contemporary problems (including ecological and evolutionary ones). Among them, especially important in this context are the con­cepts of the common task (N.N. Fedorov), the cosmic philosophy (K.E. Tsiol­kovsky), the doctrine of the noosphere (V.I. Vernadsky), and heliobiology (A.L. Chizhevsky). It is shown that the ideas of cosmism and evolutionary-eco­logical thinking are connected with such directions as A. Bergson’s creative evolution, P. Teilhard de Chardin’s theistic evolutionism, planetary evolution, and macroevolutionary research. It is precisely at the scale of the biosphere and noosphere that evolutionary and ecological principles intersect the most. The construction of the noosphere, taking into account contemporary scientific and methodological realities, is a direction of evolutionary-ecological thinking in our time
Knowledge and Subjectivation: Kant’s Pragmatic Anthropology as Read by Foucault
Authors:   Institute of Philosophy, Russian Academy of Sciences, Pisarev Alexander
Published: October 2024

The article outlines a hypothesis about the influence of Foucault’s interpretation of Kant’s “Anthropology from a pragmatic point of view” on actual research of models of the subject based on scientific knowledge. Such models in­clude cerebral, genetic, immune subjects, etc., studied by a group of approaches in the history and sociology of science, as well as in philosophy. In the introduc­tion, a brief overview of the concept of the cerebral subject is given, the main properties of this type of subject models are derived, which differ from tradi­tional philosophical subjects, closed in the immanence of philosophical thinking. The subjects thematized in this group of approaches are multiple, partial and sit­uational (depending on the situation, an individual can adopt different models), changeable (circulating, they can mutate from practice to practice), historical and performative (they are embodied in practices). The approaches themselves are anti-essentialist in nature, since they imply a critical attitude towards the natural­ization of subjects carried out by sciences and non-scientific institutions. Their predecessor was Foucault’s thematization of human in “The Order of Things” and in the commentary to Kant’s pragmatic anthropology. It is shown that Fou­cault’s ideas can be traced in the discussed approaches to the study of subjectiva­tion based on scientific experience
Multiphase Flowback Rate Transient Analysis of Multi-Fractured Horizontal Wells in Gas Condensate Shales
Authors: Yang Chia-Hsin , Emami-Meybodi Hamid , Kordestany Amin , Zhang Fengyuan
Published: October 2024

Flowback rate transient analysis (RTA) of multi-fractured horizontal wells (MFHWs) in shale gas has historically focused on single-phase or two-phase water and gas flow, ignoring the presence of condensate. We introduce a multiphase flowback RTA for MFHWs in gas condensate shales, accounting for condensate dropout when the pressure in hydraulic fractures (HFs) falls below the dewpoint. We develop a semi-analytical multiphase flowback model to analyze flowback data during HF depletion. Three flow regimes are considered: a two-phase water and gas infinite-acting linear flow (IALF), a two-phase boundary-dominated flow (BDF), and a three-phase water, gas, and oil BDF. We derive pressure diffusivity equations for water-, gas-, and oil-phase flows and employ the material balance approach to determine the average HF pressure. Defined pseudo-variables facilitate the construction of diagnostic plots for flow regime identification and specialty plots for characterizing HF properties. We obtain diagnostic plots for each phase using the developed semi-analytical solution. During the early flowback period, the water- and gas-phase diagnostic plots display a half-slope straight line, indicating the IALF regime. This is followed by a unit-slope line, signaling the transition to the BDF regime. For the oil phase, a unit-slope line denoting BDF is observed once the HF pressure drops below the dewpoint. Additionally, we validate the developed models against numerical simulations. The results show that the estimated HF permeability and fracture half-length from the models closely match the set values in the numerical model, with relative errors below 10%. Finally, we examine the applicability of the developed multiphase flowback model on an MFHW drilled in the Horn River Shale. The proposed multiphase flowback model significantly improves our understanding of the HF stimulation jobs and HF dynamics and characteristics.
The Mediating Effect of Executive Dysfunction in the Relationship between School Adaptation in Early Adolescence and Parental Attachment and Democratic Parenting Behavior in School-age
Authors: Kim Jiae , Shim Mikyung
Published: October 2024

Objective: This study was conducted to verify the mediating effect of executive function difficulties in the relationship between school adaption in early adolescence and children’s parental attachment and democratic parenting behavior in school-age.
Methods: Data of 9-year-olds from the 11th (2018) to 12-year-olds from the 14th (2021) Panel Study on Korean Children were used to extract variable data that fit the purpose of this study. Descriptive statistics were performed using SPSS 21.0, and AMOS 21.0 was used to analyze correlation, structural equation modeling, and mediating effects through bootstrapping to verify the research hypothesis model.
Results: First, school-age children’s attachment to their parents had a direct positive effect on school adaptation in early adolescence, but parents’ democratic parenting behavior did not. Second, executive function fully mediated the relationship between democratic parenting behavior and school adaptation, and partially mediated the effect of parental attachment on school adaption.
Conclusion: Executive function, secure parental attachment, and democratic parenting behavior in school-age children tended to reduce executive function difficulties in early adolescence. These results are discussed in terms of need to develop parent education programs to increase attachment to parents and teach desirable parenting behaviors. Also discussed to provide continuous and systematic guidance and education on the importance of executive function to parents.
Comparative Evaluation of Biomechanical Testing Methods for Murine Lumbar Vertebral Bodies: Identifying Optimal Techniques for Assessing Bone Structure and Stability
Authors: Kronenberg Daniel , Wieskoetter Britta , Soeger Sarah , Hidding Heriburg , Timmen Melanie , Raschke Michael J. , Stange Richard
Published: October 2024

Numerous genetically modified mouse models are available to evaluate gene functions related to bone metabolism regulation. This study aims to evaluate four prevalent biomechanical testing methods for assessing the structure and stability of murine lumbar vertebral bodies, identifying the most reliable, valid, and reproducible technique. The fourth lumbar vertebrae of 20 female C57BL/6 mice (wild type, 12 weeks) were tested, randomized into four testing groups: Method 1 - compression of the complete lumbar vertebral body (LVB) including the dorsal spinal processi; Method 2 - compression at the vertebra body surface; Method 3 - isolated resection of the vertebral arch; Method 4 - resection of the vertebral arch and straightening of the intervertebral joint surface. Compression was applied using a mono-axial static testing machine. Maximum load, stiffness, yield load, and the elasticity modulus were evaluated. Load-to-failure and yield-to-failure were significantly higher in Method 1. Method 3 showed increased stiffness and significantly increased Young's modulus. The least variation in relative load-to-failure and yield-to-failure was observed with Method 1. Method 4 exhibited the greatest overall variation in specimen values. Method 3 yielded divergent results and is not recommended. Method 1 led to the most consistent and reproducible data and is recommended.
Influence of fly ash content on macroscopic properties and microstructure of high-performance concrete
Authors: kang Mengxin , Jia Yabo , Guo Peng , Ju Yanzhong , Zhang Hongji
Published: October 2024

To study the influence of fly ash content on the performance of high-performance concrete (HPC), Seven groups of tests were conducted to evaluate macroscopic properties (workability and compressive strength) and microscopic pore structure. Low field nuclear magnetic resonance (NMR) technology and SEM images were used to analyze the changes in the internal pore structure of the concrete. The results show that the workability of HPC initially increases and then decreases with the increase in fly ash content. When the content is 15%, the slump of HPC reaches a maximum of 264 mm, and the 28-day compressive strength increases by 23.2% compared to the 7-day compressive strength. The pore size distribution of the concrete varies with different fly ash contents, with over 95% of the pores in each group measuring less than 0.1 µm. At 15% fly ash content, secondary hydration of the fly ash is sufficient, refining the pores between 0 and 0.1 µm.
Effects of visual terminal feedback on hand dexterity in relation to visuospatial ability in subacute stroke: A preliminary study
Authors: Yabuki Jun , Kaneno Tatsuya , Yamamoto Ryohei , Yamaguchi Kazuto , Nakano Wataru , Akizuki Kazunori
Published: October 2024

Hand dexterity impairments in patients with stroke reduce activities of daily living (ADL) and quality of life. Visuospatial ability is associated with motor learning, but this has not previously been reported in patients with subacute stroke. We aimed to investigate whether visual terminal feedback (FB) affected motor learning of hand dexterity and the relationship among visuospatial ability. Overall, 17 subacute stroke patients (age: 66.1 ± 13.8 years) with mild upper limb motor impairment were included. The experimental task was the grasping force control task. The visuospatial task was the Rey–Osterrieth Complex Figure Test (ROCFT). The experimental protocol was conducted in 2 consecutive days: day 1 consisted of a pre-test (PRE), practice, and short-term retention test (SRT), and day 2 consisted of a long-term retention test (LRT) and the ROCFT. Grasping errors were significantly decreased in the SRT and LRT than in the PRE. Furthermore, ROCFT scores (copy and recall) and LRT grasping errors were moderately negatively correlated (ρ = -0.51 and − 0.53). In conclusion, visuospatial ability is an important factor associated with motor learning in subacute stroke patients. Future studies should use visual terminal FB, and training programs for visuospatial ability should be considered in stroke rehabilitation.
Modeling immunoglobulin light chain amyloidosis in Caenorhabditis elegans
Authors: Romeo Margherita , Barzago Maria Monica , Corbelli Alessandro , Maglioni Silvia , Ventura Natascia , Natale Carmina , Conz Andrea , Salmona Mario , Palladini Giovanni , Nuvolone Mario , Fiordaliso Fabio , Merlini Giampaolo , Diomede Luisa
Published: October 2024

Cardiomyopathy determines the prognosis of patients with immunoglobulin light chain (AL) amyloidosis, a rare systemic disease caused by the misfolding and deposition of monoclonal light chains (LCs). The reasons underlining their cardiac tropism remain unknown, and an animal model recapitulating the main pathological features of AL amyloidosis is instrumental. Taking advantage of the similarities between the vertebrate heart and C. elegans' pharynx, we developed a new transgenic nematode expressing a human amyloidogenic λ LC whose sequence was deduced from a patient suffering from AL amyloidosis with cardiac involvement (MNH). Strains expressing a non-amyloidogenic LC (MNM) or the empty vector only (MNV) were generated as controls. At variance with controls, LCs expressed in the body-wall muscle of MNH worms formed native soluble dimeric assemblies, which were secreted and reached different organs, including the pharynx. Noteworthy, MNH worms exerted a pharyngeal impairment resembling cardiac functional impairment occurring in patients with AL, accompanied by increased radical oxygen species production and tissue ultrastructural damage. This new animal model can allow the elucidation of the mechanisms underlying the cardiac-specific tropism occurring in AL amyloidosis, providing innovative insights into the pathophysiology.
SVTSR: Image Super-Resolution Using Scattering Vision Transformer
Authors: Liang Jiabao , Jin Yutao , Chen Xiaoyan , Huang Haotian , Deng Yue
Published: October 2024

Vision transformers have garnered substantial attention and attained impressive performance in image super-resolution tasks. Nevertheless, these networks face challenges associated with attention complexity and the effective capture of intricate, fine-grained details within images. These hurdles impede the efficient and scalable deployment of transformer models for image super-resolution tasks in real-world applications. In this paper, we present a novel vision transformer called Scattering Vision Transformer for Super-Resolution (SVTSR) to tackle these challenges. SVTSR integrates a spectrally scattering network to efficiently capture intricate image details. It addresses the invertibility problem commonly encountered in down-sampling operations by separating low-frequency and high-frequency components. Additionally, SVTSR introduces a novel spectral gating network that utilizes Einstein multiplication for token and channel mixing, effectively reducing complexity. Extensive experiments show the effectiveness of the proposed vision transformer for image super-resolution tasks. Our comprehensive methodology not only outperforms state-of-the-art methods in terms of the PSNR and SSIM metrics but, more significantly, entails a reduction in model parameters exceeding tenfold when compared to the baseline model. As shown in Fig. 1, the substantial decrease of parameter amount proves highly advantageous for the deployment and practical application of super-resolution models. Code is available at https://github.com/LiangJiabaoY/SVTSR.git.
Factors associated with physical activity among Thai women with breast cancer postmastectomy at a University Hospital, Thailand
Authors: Khobkhun Fuengfa , Wichaidit Piyaporn , Sa-nguanraksa Doonyapat , Phumphuang Surat , Puranasamriddhi Saowaluck , Lohsiriwat Visnu , Kaewkhuntee Watesinee
Published: October 2024

The primary treatment for breast cancer patients is surgery and it often impacts physical activity (PA). This study aimed to investigate factors associated with the PA level of Thai women with breast cancer after surgical mastectomy at Siriraj Hospital, Thailand. Ninety-three participants were completed the questionnaires included personal information, the Global Physical Activity Questionnaire, perceived benefits, perceived barriers, perceived self-efficacy, interpersonal influence and situational influence, the Thai Body Image Index score, and the Thai Hospital Anxiety and Depression Scale. Data was analyzed using descriptive statistics and Chi-square statistics (Odds-Ratio and 95% Confidence Interval). The study found that after post-mastectomy Thai women had sufficient PA (2.8 metabolic equivalent of tasks (METs)). It was also found that PA at work was associated with occupation, higher incomes, moderate satisfaction as assessed by the Thai Body Image Index score, and higher levels of anxiety and depression. Additionally, participation in recreational activities was associated with older age, higher perceived self-efficacy, and greater interpersonal influence. By exploring these association, we can tailor supportive care strategies that address the PA needs of individuals affected by breast cancer and it is essential for developing comprehensive interventions that optimize patient health and well-being throughout the cancer journey.
Evaluation of Indocyanine Green Near-Infrared Fluorescence Imaging for Sentinel Lymph Node Mapping in Canine Mammary Tumors: a randomized clinical study
Authors: Kim Seungwook , Lee Sungin
Published: October 2024

Accurate staging by sentinel lymph node (SLN) biopsy is essential for improving prognostic outcomes of canine mammary tumors (CMT). Indocyanine green near-infrared fluorescence (ICG-NIRF) imaging offers a novel real-time approach for SLN mapping, potentially enhancing the precision of surgical SLN biopsies. This study evaluated the effectiveness of ICG-NIRF in identifying lymphatic drainage pathways and SLNs in CMT and determined the optimal ICG concentration for visualizing lymphatic channels and SLNs. We hypothesized that ICG-NIRF effectively highlights both lymphatic channels and SLNs, facilitating accurate SLN biopsies. We included 24 female dogs with cytologically diagnosed malignant CMT, from September 2023 to April 2024. ICG was injected peritumorally (concentrations: 0.5, 1.0, and 2.5 mg/mL). NIRF imaging was conducted intraoperatively to visualize lymphatic drainage and identify SLNs. Data on fluorescence intensity and operation time were collected and analyzed using ANOVA and post-hoc Tukey tests. The detection rate of SLNs using ICG-NIRF was 94.4% (34/36). Highest LN fluorescence (p = 0.030) and shortest operation time (p = 0.002) were yielded by 1.0 mg/mL ICG, with minimal false-negative rates. ICG-NIRF imaging was successfully utilized for SLN mapping of CMT, demonstrating a high detection rate. This method enhances the precision of SLN biopsies, improving surgical outcomes in both veterinary and human oncology.
Development of the Uskudar Self-Consciousness Scale and Examination of its Psychometric Properties in the Context of Skepticism and Narcissism
Authors: Tarhan Nevzat , Tutgun-Ünal Aylin , Arıkan Muhammed
Published: October 2024

Background
Self-consciousness means focusing on one’s own actions, knowing oneself, and is also a sign of increasing psychological problems in our age. Because a person’s lack of consciousness of their inner world, inconsistencies in their behaviors in the face of events, and the accompanying decrease in emotional literacy can disrupt the person’s integrity within themselves and within society. Skepticism and increasing narcissism can cause these situations, as well as being the root causes of lack of self-consciousness.
Methods
This study aimed to develop a valid and reliable dimensional Uskudar Self-Consciousness Scale (USSCS) that includes two perspectives by focusing on skepticism and narcissism, and to examine its psychometric properties. Data were collected from 1119 participants across Turkey.
Results
As a result of the study, the Uskudar Self-Consciousness Scale consisted of two independent scales: Uskudar Skepticism Scale (USSES) and Uskudar Narcissism Scale (USNAS). The first scale, USSES, consisted of 20 items and 4 dimensions, and the structure explained 52.92% of the total variance. Cronbach Alpha internal consistency reliability coefficient was found to be .89 in the total scale. The second scale, USNAS, consisted of 25 items and 5 factors. The total variance explained was 52.75%. Cronbach Alpha internal consistency was found to be .90. As a result of the modeling studies of both scales, the scale structures were confirmed, and the goodness of fit values ​​were within the acceptable range.
Conclusions
According to the first results obtained in the study; (a) Young generations are more skeptical and their narcissism is high, (b) Skepticism and narcissism increase as the level of education increases, (c) In the 1119-person Turkey sample, skeptical affect and narcissism were found to be at a low level. As a result, the emergence of a valid, reliable and dimensional self-consciousness self-assessment scale that includes skepticism and narcissism and its introduction to the literature has emerged as the original aspect of this study.
Efficacy of galactose-deficient IgA1 as a biomarker for predicting IgA nephropathy recurrence after kidney transplantation: a retrospective case-control study
Authors: Deng Ronghai , Chen Wengen , Chang Xinhua , Chen Zehuan , Ye Qianyu , Xu Bowen , Gao Yifang , Deng Suxiong , Yu Xiaolin , Wang Changxi , Liu Xiangjun
Published: October 2024

Background
Allogeneic kidney transplantation (KT) is an effective treatment for end-stage renal disease caused by progressing immunoglobulin A nephropathy (IgAN). However, the post-KT IgAN recurrence rate is high and can shorten long-term graft survival. Therefore, early prediction of IgAN recurrence risk is crucial for improving transplantation outcomes. We hypothesized that serum galactose-deficient IgA1 (Gd-IgA1), APRIL, B-cell activating factor (BAFF), and sCD89 levels could help predict IgAN recurrence post-KT. Thus, this study aimed to validate our hypothesis in Chinese patients with IgAN.
Methods
In this retrospective case-control study, we examined patients with primary IgAN who underwent KT at the First Affiliated Hospital, Sun Yat-sen University from September 2014 to December 2019. Patients were divided into post-transplantation IgAN recurrence (n = 12) and non-recurrence (n = 13) groups. Serum levels of Gd-IgA1, APRIL, BAFF, and sCD89 were measured at pre-transplantation and at 1–6, 6–12, 12–24, and > 24 months post-transplantation.
Results
The area under the curve for predicting IgAN recurrence at 1–6 months post-transplantation was 0.91 (95% confidence interval [CI], 0.78–1; cutoff, 4.2 µg/mL), 0.79 (95% CI, 0.58–1; cutoff, 933 pg/mL), and 0.8 (95% CI, 0.6–1; cutoff, 1791 pg/mL) for Gd-IgA1, BAFF, and APRIL, respectively. At 6–12 months post-transplantation, it was 0.82 (95% CI, 0.6–1; cutoff, 2.37 µg/mL) and 0.9 (95% CI, 0.74–1; cutoff, 992 pg/mL) for Gd-IgA1 and BAFF, respectively. Finally, at 12–24 months post-transplantation, it was 0.91 (95% CI, 0.76–1; cutoff, 3.83 µg/mL) for Gd-IgA1. Compared to patients with post-transplantation Gd-IgA1 levels < 4.2 µg/mL, patients with Gd-IgA1 levels ≥ 4.2 µg/mL at 1–6 months post-transplantation had a hazard ratio (HR) of 25.38 (95% CI, 2.5–257.88, p = 0.006) for IgAN recurrence. BAFF levels at 1–6 months post-transplantation were protective against IgAN recurrence (HR, 0.03; 95% CI, 0–0.48; p = 0.013).
Conclusions
Serum Gd-IgA1 levels could effectively predict IgAN recurrence risk in patients post-KT.
Down-regulation of Long Non-coding RNA H19 and ADCK4 gene in Children with Nephrotic Syndrome
Authors: Asar Mohamed , Elmalawany Alshimaa , Zaid Ahmed , Atlam Sarah , El-Torgoman Abdel Moneim , Mohamed Sanaa , El-niadany Sherin
Published: October 2024

AIM OF THE WORK: The objective of this study is to examine the correlation between the long non-coding RNA H19 and ADCK4 genes and the susceptibility to nephrotic syndrome in children from Egypt.
METHODS: A cross-sectional research was conducted on 50 cases with nephrotic syndrome and 50 controls of apparently healthy children with no past or family history of renal or chronic diseases. Each participant signed their informed consent form. The study excluded malignancy, chronic infectious disorders, drug-induced membranous glomerulonephritis (MGN) or lupus nephritis.
RESULTS: There was a significant divergence among cases and control regarding RQ (ADCK4) (p-value < 0.001) and RQ (H-19) (p-value < 0.001). Nevertheless, no notable distinction was observed between the two forms of nephrotic syndrome in terms of RQ (ADCK4) (p-value =0.935) and RQ (H-19) (p-value 0.525).
CONCLUSION:In nephrotic syndrome, the RNA H19 and ADCK4 genes are downregulated, with no notable distinction observed between the steroid-sensitive and steroid-resistant patient groups.
Patient delays and medical care delays among elderly tuberculosis patients in Chongqing, China
Authors: Xiangliu Wang , Wenjun Luo , Hui Luo , Chengguo Wu , Lihong Mu , Chuan PU
Published: October 2024

Background
China is one of the countries with a high global burden of tuberculosis (TB). Chongqing is the most populous city in southwestern China and one of the provinces with a high degree of aging. This study aimed to analyse the delays in consultation and diagnosis of elderly patients with tuberculosis in Chongqing, to explore the reasons behind these delays, and to propose strategies to address these problems.
Methods
Based on the TB data extracted from the China Tuberculosis Management Information System from 2016 to 2022, TB patients aged ≥ 65 years with complete registration information who were currently residing in Chongqing Municipality during the 7-year period from 2016 to 2022 were selected. One-way c2 test and multifactorial logistic regression were used to analyse the factors affecting delay in consultation and delay in the healthcare system among elderly TB patients.
Results.
A total of 29,337 patients were included in this study. Between 2016 and 2020, there was a decreasing trend in both consultation delays and healthcare system delays in Chongqing. The median time of visit delay was 36 (15, 91) visit delay rate was 76.1%; the median time of healthcare system delay was 1 (1, 6) and healthcare system delay rate was 12.4%. Women (OR = 1.15,95%Cl:1.077,1.227), elderly TB patients who belonged to a mobile population (OR = 1.157,95%Cl:1.031,1.297) with comorbidities (OR = 1.084,95%Cl:1.026,1.145) were at higher risk of visit delay. Unemployed (OR = 1.349,95%Cl:1.198,1.520) and retired (OR = 1.820,95%Cl:1.641,2.019), mobile (OR = 1.445,95%Cl:1.272,1.642), with comorbidities (OR = 1.113,95%Cl:1.04,1.20), and Older TB patients who were first seen in the main urban area (OR = 1.721,95%Cl:1.566,1.891) were more likely to experience delays in the healthcare system.
Conclusions
Both TB visit delays and healthcare system delays have improved in Chongqing, but TB visit delays are still more prominent in the elderly population. To effectively address this problem, it is particularly important to strengthen health education efforts for the elderly population and key TB target groups, to enhance the professional capacity of primary health care institutions in TB screening, and to promote the in-depth application of Internet technology in TB prevention and control. The implementation of these measures will be of inestimable value in reducing delays in patient consultation and optimising the response efficiency of the healthcare system.
Process Evaluation of the Follow-Up Care System for Suicide Attempt in Iran: A Mixed- Method Study
Authors: Shirzad Fatemeh , Fahim Forouzan , Naserbakht Morteza , Hajebi Ahmad , Shariat Seyed Vahid , Naseh Mohammad Hadi , Ahadi Parisa , Khougar Ansar
Published: October 2024

Background
Despite ongoing efforts to provide hospital and post-discharge care for suicide attempters in Iran, national suicide rates continue to exhibit a concerning upward trend. This study employs the MRC framework, a comprehensive evaluation tool, to conduct a process evaluation of Iran's suicide follow-up care system in Shahriar city.
Methods
We examined fidelity, dosage, reach, impact, and contextual determinants of the program. An explanatory sequential design was employed. Data from 992 suicide attempt cases collected between April and September 2023. Semi-structured interviews were conducted with 19 mental health workers, 2 mental health experts, 16 hospital staff members, and 8 individuals with who have suicide attempts.
Results
Findings indicated that of the 992 individuals referred for receive services, only a small number (n = 15) engaged with designated health centers, with a completion rate of a mere 3 individuals, suggesting significant limitations in program reach. Qualitative analysis revealed nine thematic domains aligned with the MRC framework: infrastructure, information gaps, and human resource challenges within implementation mechanisms; participant experiences, and acceptability, related to impact mechanisms; and socioeconomic factors, stigma, organizational barriers, and access to means restriction as contextual components.
Conclusion
This study in Iran offers a unique contribution by employing a comprehensive framework to systematically evaluate the national suicide follow-up system, its role within broader prevention efforts, and strategies to enhance program effectiveness. The Follow-Up Care System for Suicide Attempt provides a crucial resource for Shahriar residents at risk of suicide, who often grapple with compounded challenges stemming from socioeconomic factors. Our findings underscore critical operational and contextual barriers, providing essential evidence for policymakers to address. While demonstrating initial promise, the program requires substantial improvements. To maximize its impact, we need to strengthen program implementation, allocate sufficient resources, build community partnerships, and advocate for policy changes that address the root causes of these issues.