bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Pan-Genomes of Crops: Genomic Resources and Tools for Unraveling Gene Evolution, Function, and Adaptation
Authors: Naithani Sushma , Deng Cecilia H. , Sahu Sunil Kumar , Jaiswal Pankaj
Published: August 2023

The availability of multiple sequenced genomes from a single species made it possible to explore intra- and inter-specific genomic comparisons at higher resolution and build clade-specific pangenomes of several crops. The pan-genomes of crops constructed from various cultivars/accessions, landraces, and wild ancestral species represent a compendium of genes and structural variations and allow researchers to search for the novel genes and alleles that were inadvertently lost in domesticated crops during the historical process of crop domestication or in the process of extensive plant breeding. Fortunately, many valuable genes and alleles associated with desirable traits like disease resistance, abiotic stress tolerance, plant architecture, and nutrition qualities exist in landraces, ancestral species, and crop wild relatives. The novels genes from the wild ancestors and landraces can be introduced back to high-yielding varieties of modern crops by implementing classical plant breeding, genomic selection, and transgenic/gene editing approaches. Thus, pan-genomic represents a great leap in plant research and offers new avenues for targeted breeding for mitigating the impact of global climate change. Here we summarize the tools used for pangenome assembly and annotations, web-portals hosting plant pangenomes. Furthermore, we highlight a few discoveries made in crops using the pan-genomic approach and its future potential.
Metachronous Mucinous Breast Carcinoma and Mucinous Pancreatic Cystadenoma in a Patient With Metabolic Comorbidities- Case Report and Minireview
Authors: Alexescu Teodora-Gabriela , Obada Irina , Cozma Angela , Alb Mirela , Orăsan Olga Hilda , Negrean Vasile , Domsa Iacob , Tarmure Simina Felicia
Published: August 2023

Mucinous breast carcinoma is a rare subtype of mammary neoplasm encountered in medical practice. It represents approximately 1-6% of all breast cancers and is more common in postmenopausal women.
There are two subtypes of mucinous breast carcinoma: pure and mixed.
We report the case of a 73-year-old Caucasian woman diagnosed with mucinous pancreatic cystadenoma in 2007. She underwent a surgical procedure involving pancreatectomy of the body and tail, along with multiple known cardiovascular and metabolic comorbidities.
In November 2019, during a clinical-biological evaluation for associated diseases, a mucinous carcinoma of the right breast was accidentally detected and later confirmed through further investigations. For treatment, a surgical procedure was performed involving lower right quadrantectomy with right axillary lymph node dissection. The postoperative clinical course was favorable.
In conclusion, we present the case of a patient diagnosed with mixed mucinous breast carcinoma, without axillary lymph node invasion. Postmenopausal women with diabetes, overweight, and obesity have an increased susceptibility to breast cancer, with our patient having all these risk factors. To date, no study has demonstrated the genetic or radiation implication in the occurrence of mucinous carcinomas, nor the possible development of mucinous carcinomas in series in the same patient. Current data are insufficient to provide recommendations for the screening of malignant mucinous tumors in subjects with significant cardiometabolic risk factors.
Determination of the electric field strength of high-voltage substations
Authors: Koliushko D. G. , Rudenko S. S. , Tyutyuma S. O. , Vorobiov B. V.
Published: August 2023

The electric field strength is one of the main factors influencing sensitive microprocessor equipment and personnel on power stations and substations, power lines. Determining its level is an important applied task for ensuring the safe operation of electrical installations. The aim is to develop calculation relationships for determining the electric field strength created by the busbar of high-voltage substations in the working areas of personnel. The solution of the problem was based on the use of the method of equivalent charges to determine the strength of the electric field created by the complex busbar of high-voltage substations. Methodology. The development was based on solving the problem of the potential of the electric field of a point charge located in a dielectric half-space for a cylindrical coordinate system. By representing the electrode in the form of a set of point charges and subsequent integration, an expression for calculating the potential is obtained, created by a busbar of arbitrary orientation of finite length in an analytical form. Using the principle of superposition of fields and the definition of the derivative, expressions were obtained for calculating the vertical component of the electric field strength at given heights. Results. Based on the obtained expressions, using Visual Basic, the simulation of the distribution of the electric field strength under a three-phase power line with a voltage of 150 kV was performed. Comparison with the known calculation results obtained on the basis of analytical expressions for infinitely long conductors showed that the obtained expressions have an error of no more than 7%. The scientific novelty lies in the fact that for the first time expressions were obtained for determining the electric field strength created by a system of electrodes of finite length, based on the analytical method for solving differential equations. Practical significance. The proposed technique is implemented as a test module of the LiGro specialized software package, which allows modeling complex busbar systems typical for power stations and substations and power lines. A test calculation was carried out for an operating substation of regional electric networks with a voltage class of 110 kV. By comparing the duration of the calculation of switchgears with a diagonal of about 500 m, it was found that the calculation time in the LiGro complex based on the analytical method is several tens of times less than the calculation based on the finite element method. In addition, a more powerful computer was used for the end element simulation.
Simulation of the magnetic field in residential buildings with built-in substations based on a two-phase multi-dipole model of a three-phase current conductor
Authors: Rozov V. Yu. , Pelevin D. Ye. , Kundius K. D.
Published: August 2023

Problem. Substations 10(6)/0.4 kV built into residential buildings create a magnetic field with magnetic flux density of more than 10 μT in nearby residential premises, which is a danger to the health of the population and makes the study of this magnetic field relevant for the development of methods for its protection. The main source of the substations external magnetic field is their low-voltage current conductor, the contribution of which to the total level of the magnetic field is more than 90 %. Multi-dipole mathematical models, which have a clear physical interpretation, are a promising method of modeling the substations magnetic field, which is important for the further development of methods of population protection. The purpose of the work is to modify the well-known multi-dipole model for calculation based on it with a limited error of the external magnetic field of current conductors of built-in substations that are close to residential buildings at a distance of up to one meter. Methodology. A modified two-phase multi-dipole mathematical model of the main source of the external magnetic field of substation – its three-phase low-voltage current conductors – is proposed, which, unlike the existing model, is based on a two- you to halve the distance to the area of calculation without increasing the error. Verification. An experimental verification of the modified two-phase multi-dipole model of the magnetic field of a three-phase 100 kVA transformer substation on its full-scale physical model was carried out, and the results of the experiment were presented, confirming the coincidence of the calculation and the experiment with a spread of no more than 7 %.
PENGARUH KEMANDIRIAN BELAJAR DAN GAYA KOGNITIF TERHADAP HASIL BELAJAR IPS SISWA KELAS VII SMP NEGERI SINGKAWANG
Authors: Rizqi Alghofiqi  , Etin Solihatin  , Yufiarti
Published: August 2023

This study aims to determine the effect of learning independence and cognitive style on social studies learning outcomes for seventh grade students of Singkawang State Junior High School. This research was conducted on seventh grade students of public junior high school in Singkawang city, West Kalimantan. The time of the research was carried out in the odd first semester of the 2021/2022 academic year. This study uses a survey method with a regression approach. Data collection techniques used are indirect communication techniques for learning independence data as well as cognitive style and documentation for student social studies learning outcomes data. As for knowing the effect of learning independence and cognitive style on student learning outcomes, simple linear regression formulas and multiple regressions using the computerized program SPSS 16.0 will be used. By using this SPSS, the results of data analysis stated that there was an influence between learning independence and cognitive style on student learning outcomes of 0.765 (R) with R Square of 0.575 which was determined by the formula KD = R2 x 100% (KD = 0.575 x 100%) to 57.5%, while 42.5% was influenced by other factors not discussed in this study. And in this study, the level of influence was found to be sufficient.
THE ROLE OF THE 2013 CURRICULUM STUDENT WORKSHEET (LKPD) ON INDEPENDENT LEARNING STUDENTS IN PANCASILA AND CITIZENSHIP EDUCATION (Descriptive Study in 9th Grade SMP Negeri 10 Serang City)
Authors: Angraeni Desti , Ria Yuni Lestari  , Wika Hardika Legiani
Published: August 2023

Abstract: The purpose of this study was to describe the process of making the 2013 Curriculum LKPD in Pancasila and Citizenship Education subjects, to determine the role of the 2013 Curriculum LKPD in increasing the independence of students in Pancasila and Citizenship Education subjects, and to find out the obstacles to using the 2013 Curriculum LKPD in increasing independence. students in Pancasila and Citizenship Education lessons at SMP Negeri 10 Serang City. This study uses a descriptive method with a qualitative approach and data collection through the results of interviews, observations and documentation to the deputy principal of the curriculum, teachers, and students of Junior High School Number 10 of  Serang City. The results of this study indicate that the process of making LKPD Curriculum 2013 in the subjects of Pancasila and Citizenship Education is carried out by conducting curriculum analysis, compiling a map of LKPD needs, determining the title of KPD, writing LKPD and determining assessment tools. There is a role for the 2013 Curriculum LKPD in increasing the independence of students' learning in the subjects of Pancasila and Citizenship Education, namely creating a condition where students have a competitive desire to advance for their own good, as a learning tool so that students are able to take decisions and take initiatives to deal with problems that arise. faced, as a tool to foster students' confidence in what they are doing. The obstacles faced by teachers and students in utilizing the 2013 Curriculum LKPD in increasing the learning independence of students themselves both internally and externally are consistency, creativity, lack of student focus, weak grasping power of students in understanding the material and distance learning in pandemic conditions. covid 2019. 

Keywords : LKPD, Independence, Pancasila Education and Citizenship
PENGEMBANGAN APLIKASI MOM (MORAL OF MOSLEM) UNTUK PEMBENTUKAN AKHLAK TERPUJI SISWA KELAS 6 SEKOLAH DASAR
Authors: Friska Siti Mutammimah  , Dea Nur Hafifah  , Putri Nur Deswanti  , Salsabila Amalia  , Ani Nur Aeni
Published: August 2023

The development of technology in the era of 4.0 is very rapid and commendable moral values that have been rarely found in children today are the background for the development of the MOM application (Moral Of Moslem) as a learning medium that is expected to foster commendable morals in elementary school students in grade 6. This research aims to design and develop a MOM application that is suitable for use in accordance with the 8th lesson of Islamic Religious Education and Budi Pekerti in the 6th grade of elementary school. The method used in this study is Design and Development. This MOM application received an assessment from media experts of 90.75% as well as an assessment from material experts with an average of 93.75% with the interpretation of both being "Excellent". Judging from the assessment the teacher gets 98% with the interpretation of "Excellent", as well as 94.7% students with the interpretation of "Excellent". Based on these data, the development of the MOM application is very well used against the formation of commendable morals of elementary school 6th grade students.
ANALISIS PELAKSANAAN PEMBELAJARAN MEMBACA PERMULAAN ANAK BERKEBUTUHAN KHUSUS DI KELAS RENDAH SD PERTIWI MAKASSAR
Authors: Muryono  , Erwin Akib  , Muhammad Akhir
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pelaksanaan pembelajaran membaca permulaan yang dilakukan oleh anak berkebutuhan khusus (Autis) SD Pertiwi Makassar Kecamatan Rappocini Kota Makassar, untuk mengetahui faktor pendukung dan penghambat membaca permulaan yang dilakukan oleh anak berkebutuhan khusus (Autis) SD Pertiwi Makassar Kecamatan Rappocini Kota Makassar. Penelitian ini menggunakan deskriptif kualitatif. Data dikumpul melalui wawancara, observasi, dan dokumentasi. Penelitian ini menggunakan teknik analisa data, yang terdiri dari tahap pengumpulan data, reduksi data, sajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan anak berkebutuhan khusus adalah anak yang dalam proses tumbuh kembangnya mengalami gangguan dan hambatan secara bermakna dari kriteria normal dalam karakteristik mental, intelektual, sensorik, neuromotor, fisik, perilaku sosial, kemampuan berkomunikasi kesulitan belajar, berpenyakit kronis, atau gabungan dari dua atau lebih karakteristik tersebut, dan karena gangguan dan hambatan tersebut diperlukan modifikasi layanan pendidikan yang disebut pendidikan khusus untuk mengajar anak berkebutuhan khusus membaca permulaan
EVALUASI KEBIJAKAN PROGRAM KAMPUS MENGAJAR ANGKATAN 3 DI SD NEGERI TUMBREP 01
Authors: Haniyuhana Ananda , Katerina Bataha
Published: August 2023

Kampus mengajar adalah salah satu dari sekian produk kebijakan publik yang dicanangkan oleh Direktorat Pembelajaran dan Kemahasiswaan, Kementrian Pendidikan dan Kebudayaan Republik Indonesia. Program ini bertujuan untuk memberikan kesempatan bagi mahasiswa untuk dapat mengasah jiwa kepemimpinan, karakter serta memiliki pengalaman belajar mengajar. Diharapkan dengan adanya program kampus mengajar dapat memberikan peningkatan efektivitas proses pembelajaran dalam kondisi darurat covid-19. Tujuan dari penelitian ini adalah untuk mendeskripsikan dan menganalisis evaluasi pendidikan numerasi dan literasi melalui program kampus mengajar angkatan 3 di SD Negeri Tumbrep 01. Jenis penelitian yang digunakan pada penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif. Dengan penggunaan metode evaluasi yang digunakan yaitu metode Context, Input, Process, and Product (CIPP). Jika dilihat dari hasil evaluasi menggunakan metode CIPP, masih terdapat beberapa hambatan-hambatan yang harus diselesaikan demi keberhasilan program kampus mengajar angkatan selanjutnya. Hambatan – hambatan tersebut diantaranya adalah keterbatasan tenaga pendidik dan sarana prasarana serta kurangnya kesadaran siswa mau pun wali murid dalam membantu suksesnya pelaksanaan program kegiatan kampus mengajar angkatan 3 di SD Negeri Tumbrep 01.
PENGARUH MEDIA ANIMASI AUDIO VISUAL TERHADAP PERSEPSI DAN KEMAMPUAN PEMAHAMAN KONSEP SISWA PADA PELAJARAN IPS KELAS V
Authors: Fadilah Idris  , Nursalam  , Muhlis Madani
Published: August 2023

Tujuan penelitian adalah untuk menganalisis kemampuan pemahaman konsep IPS pada siswa kelas V; menganalisis persepsi belajar siswa melalui pembelajaran animasi audio visual; dan untuk mengetahui pengaruh media animasi audio visual terhadap kemampuan pemahaman konsep dan persepsi siswa kelas V. Jenis penelitian ini adalah Quasi Eksperimental Design dalam penelitian ini diberikan perlakuan tertentu (treatment), yaitu kelas kontrol dan kelas eksperimen. Sampel dalam penelitian ini adalah sebagian dari populasi dengan Teknik pengambilan sampel adalah purposive sampling. Metode pengumpulan data yang digunakan yaitu kuesioner motivasi dan tes hasil belajar serta dokumentasi.  Tehnik analisis data yang digunakan yaitu pertama dengan menggunakan pendekatan statistik deskriptif, uji prasyarat, dan uji hipotesis Manova. Hasil penelitian, uji hipotesis Manova pada Uji multivariate bahwa nilai signifikansi media animasi audio visual terhadap motivasi dan hasil belajar siswa adalah 0,000 < 0,05 maka H1 diterima dan Ho di tolak, dan selanjutnya dilakukan uji Tests of Between-Subjects Effects dengan nilai signifikansi pengaruh media animasi audio visual terhadap persepsi dan kemampuan pemahaman konsep IPS siswa sebanyak 0,000 yang berarti nilai signifikansi 0,000<0,05, yang berarti bahwa H1 diterima dan Ho di tolak dengan penarikan kesimpulan bahwa ada pengaruh yang signifikan media animasi audio visual terhadap persepsi dan kemampuan pemahaman konsep IPS materi jenis-jenis dan kegiatan ekonomi masyarakat pada siswa kelas V.

.Kata Kunci : audio visual, pemahaman konsep, persepsi
ANALISIS KETERAMPILAN ABAD 21 PADA PEMBELAJARAN TEMATIK
Authors: Rindiani  , Nurhasanah Ana , Alamsyah Trian Pamungkas
Published: August 2023

Penelitian ini dilandasi urgensi adanya tantangan bagi guru dalam menciptakan perencanaan pembelajaran yang matang sehingga dapat menghasilkan peserta didik yang unggul dan mampu bersaing dengan mengembangkan keterampilan abad 21. Tujuan dari penelitian ini adalah untuk mendeskripsikan pemanfaatan sarana dan prasarana penunjang kegiatan pembelajaran di abad ke-21, proses penerapannya, dan hasil dari kegiatan pembelajaran yang memfokuskan pada keterampilan abad 21 yang mencakup keterampilan 4C (berpikir kritis, kreatif, bekerja sama atau kolaborasi, dan berkomunikasi) pada pembelajaran tematik di kelas V SDN Sumampir. Penelitian ini menggunakan pendekatan kualitatif dan metode deskriptif. Subjek dalam penelitian ini adalah guru kelas V dan 30 peserta didik, melalui teknik pengumpulan data triangulasi teknik seperti wawancara, observasi, dan dokumentasi, dengan menggunakan model analisis data Miles dan Huberman, yang terdiri dari proses pengumpulan data, reduksi data, penyajian data, dan verifikasi/penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa pemanfaatan sarana dan prasarana sebagai penunjang kegiatan pembelajaran abad ke-21 di SDN Sumampir belum cukup optimal karena adanya keterbatasan jumlah, guru kelas V sudah mengimplementasikan keterampilan abad 21 dalam kegiatan pembelajaran dengan keterampilan mengajar yang dimilikinya, dan peserta didik kelas V sudah optimal dalam menerapkan keterampilan 4C pada kegiatan pembelajaran tematik.
Is Elective Total Hip Arthroplasty Safe in Nonagenarians?
Authors: Leopold Vincent J. , Krull Paula , Hardt Sebastian , Hipfl Christian , Melsheimer Oliver , Steinbrück Arnd , Perka Carsten , Giebel Gregor M.
Published: August 2023

Background:

An increasing number of elderly patients are becoming candidates for elective total hip arthroplasty (THA). Conflicting results exist with regard to the safety of THA in nonagenarians. The aims of this study were to evaluate postoperative mortality and morbidity after THA in nonagenarians and underlying risk factors. We hypothesized that nonagenarians undergoing elective THA would show higher morbidity than younger patients and higher mortality than nonagenarians in the general population.

Methods:

This was an observational cohort study using data from the German Arthroplasty Registry (Endoprothesenregister Deutschland [EPRD]). Of 323,129 THAs, 263,967 (including 1,859 performed on nonagenarians) were eligible. The mean follow-up (and standard deviation) was 1,070 ± 641 days (range, 0 to 3,060 days). The exclusion criteria were age of <60 years at admission and nonelective THAs or hemiarthroplasties. The cohort was divided into 4 age groups: (1) 60 to 69 years, (2) 70 to 79 years, (3) 80 to 89 years, and (4) ≥90 years. Comorbidities representing independent risk factors for postoperative complications and mortality were identified via a logistic regression model. Mortality rates were compared with those from the general population with data from the Federal Statistical Office. The end points of interest were postoperative major complications, minor complications, and mortality.

Results:

Among the greatest risk factors for major and minor complications and mortality were congestive heart failure, pulmonary circulation disorders, insulin-dependent diabetes, renal failure, coagulopathy, and fluid and electrolyte disorders. Compared with younger groups, the risks of major and minor complications and mortality were significantly higher in nonagenarians. Mortality increased when major complications occurred. After 1 year, the survival rate in patients without a major complication was 94.4% compared with 79.8% in patients with a major complication. The mortality rates of nonagenarians in the study population were lower than those in the corresponding age group of the general population. The 1-year mortality rates at 90 years of age were 10.5% for men and 6.4% for women within the study group compared with 18.5% for men and 14.7% for women among the general population.

Conclusions:

Comorbidities favor the occurrence of complications after elective THA in nonagenarians and thus increase postoperative morbidity. In the case of complications, mortality is also increased. The fact that mortality is still lower than within the general population shows that this aspect can be controlled by careful patient selection and adequate preparation.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Parsonage-Turner Syndrome in a 9-Year-Old Boy
Authors: Donadeu Sánchez Susana , Arvinius Camila , Fernandez Fernandez-Arroyo Antonio , Llanos Perez David , Alambrada Valverde Mercedes
Published: August 2023

We present the case of a 9-year-old boy who presented to the emergency department with acute shoulder pain that progressed to right arm radialis paralysis. After a magnetic resonance imaging, he was diagnosed with Parsonage-Turner syndrome and treated accordingly. Parsonage-Turner syndrome (PTS) is an uncommon disorder in children. Only case reports or small series have being published around this topic in the pediatric population. Sudden pain with loss of strength on the upper extremities after a viral infection should make physicians include PTS in the diagnosis. Current treatment includes pain relief and physiotherapy, to regain as much function as possible.
Hiper Yerel Gazeteciliğin Türkiye’de Sürdürülebilirliği: Sektör Temsilcileri Üzerine Bir Çalışma
Authors: KARTAL Neziha
Published: August 2023

Vatandaş gazeteciliğinin yerel boyutunu ifade etmek için kullanılan hiper yerel gazetecilik, yerel medyaya yeni bir bakış getirmiştir. Hiper yerel gazetecilik; küçük kasaba veya mahallede, toplulukların haberlerinin vatandaşlarca bir medya kuruluşu bünyesinde aktarıldığı gazetecilik türüdür. Hiper yerel gazetecilikte yerel halk, haberin kaynağı olmanın dışında haberi üretip yayınlayabilmektedir. Hiper yerel gazeteciliği diğer yerel gazetecilik yapılarından ayıran en temel özelliklerinden biri de pozitif haber üretimidir. Hiper yerel gazetecilik özellikle okuyucu ile medya arasındaki ilişkinin yeniden kuvvetlenmesi ve sürdürülebilir hale gelmesi için umut vadeden bir model olarak karşımıza çıkmaktadır. Medyada kendisine yer bulamayan küçük topluluklara ulaşılması, muhabirlerin ulaşamayacağı noktalarda yeni bir haber ağı oluşturulması ve haber ağının genişletilmesine önemli bir katkı sağlamaktadır. Bu çalışmanın amacı, hiper yerel gazeteciliğin yerel basına getireceği olumlu olumsuz yönleri betimlemektir. Çalışmada Adana yerel basını örneklem olarak alınmıştır. Yarı yapılandırılmış görüşme yöntemi kullanılarak nitel bir çalışma gerçekleştirilmiştir. Araştırmada hiper yerel gazeteciliğin haber içeriklerini çeşitlendireceği, tirajı arttıracağı, vatandaş haberciliğinin daha sistemli hale geleceği ve bütün bunların yerel basın için önemli katkılar sağlayacağı sonucuna ulaşılmıştır. Araştırmadan çıkan diğer bir sonuç ise bu olumlu katkıların olabilmesi için öncelikle okurlara eğitim verilmesi, okurdan gelen haber için ayrı bir editörün bulunması ve bunun için ekonomik desteğin gerekliliğidir.
Designing Institutional Systems that Support Neurodivergent Educators
Authors: Scott Mike , Gibson Poppy Frances
Published: August 2023

In higher education (HE) institutions, neurodivergence is currently under-represented (Mellifont, 2021). This opinion piece explores the role of institutional systems in supporting neurodivergent educators who bring unique strengths and perspectives to the classroom. The paper suggests that designing inclusive hiring processes and providing professional development opportunities, mentorship programmes and accommodations in the classroom are ways to support neurodivergent educators. The paper also highlights the benefits of remote or blended work arrangements and discusses the challenges associated with designing institutional systems that support neurodivergent educators. The paper concludes that creating a welcoming and inclusive workplace culture and prioritising essential accommodations are necessary in order to foster a more inclusive and effective learning environment for all students and educators.
Enhancing student understanding through playful learning using Playmobil pro
Authors: Parkin John
Published: August 2023

A growing body of evidence shows the value of playful learning and using playful approaches such as Lego Serious Play. However, little research has investigated the effectiveness of Playmobil pro to support higher education teaching and learning. This case study investigates how Playmobil pro can be used to support final-year Primary Education Studies undergraduates to deepen understanding through a playful approach. Methods used are the analysis of Playmobil pro representations and exit tickets completed by participants. Playmobil pro supported student understanding by providing a play-learning tool to assist the construction of models in order to create meaning and support rich discussions about concepts. The implications of this research include the potential of Playmobil pro to be a tool used in higher education to support student learning and engagement.
New diagnostic criteria for metopic ridges and trigonocephaly: a 3D geometric approach
Authors: Bloch Kevin , Geoffroy Maya , Taverne Maxime , de Lande Lara van , O’Sullivan Eimear , Liang Ce , Paternoster Giovanna , Moazen Mehran , Laporte Sébastien , Khonsari Roman Hossein
Published: August 2023

Background
Trigonocephaly occurs due to the premature fusion of the metopic suture, leading to a triangular forehead and hypotelorism. It often requires surgical correction for morphological and functional indications. Metopic ridges (MR) also originate from premature metopic closure but are only associated with mid-frontal bulging; their surgical correction is rarely required. Differential diagnosis between these two conditions can be challenging, especially in minor trigonocephaly.
Methods
207 scans of patients with trigonocephaly (90), MR (27), and controls (90) were collected. Geometric morphometrics were used to quantify skull and orbital morphology as well as the interfrontal angle and the cephalic index. An innovative method was developed to automatically compute the frontal curvature along the metopic suture. Different machine-learning algorithms were tested to assess the predictive power of morphological data.
Results
We showed that control patients, trigonocephaly and MR have distinctive skull and orbital shapes. The 3D frontal curvature enabled a clear discrimination between groups (sensitivity and specificity > 92%). Furthermore, we reached an accuracy of 100% in group discrimination when combining 6 univariate measures.
Conclusion
Two diagnostic tools were proposed and demonstrated to be successful in assisting differential diagnosis for patients with trigonocephaly or MR. Further clinical assessments are required to validate the practical clinical relevance of these tools.
Diffusion calculations on reconstructed bentonite microstructures with anion exclusion effects
Authors: Bouchelaghem Fatiha
Published: August 2023

Due to their prevalence in the lithosphere and their high capability of sorbing pollutants, smectite clays play a foreground role in environmental pollution studies, waste management and soil science. In complementarity with existing approaches at the molecular or macroscopic scales, real microstructures have been employed to investigate ionic transport by diffusion through montmorillonite and water-saturated Wyoming bentonite at intermediate scales ranging between the nanometer and the micrometer. The coupled solute transport and electrostatic phenomena investigated at the nanopore scale are upscaled using the Homogenization of Porous Media approach. Homogenization computations rely on a hierarchical description of bentonite that acknowledges the existence of pores networks at different scales. At the scale of montmorillonite layers, digitized TEM images have been employed to simulate diffusion of ionic solutes by considering electrostatic interactions in the vicinity of the negatively-charged clay platelets’ surface. Finite Element microstructures are created after extraction of the contours of the layers using dedicated image processing algorithms. Local electric potential distribution, anion exclusion and cation inclusion are displayed by ion distribution maps. The effective diffusion tensor and the transport equation obtained through volume averaging are then used to simulate diffusion at the scale of a Wyoming bentonite sample composed of clay gels of variable density, mineral grains and micropores. Qualitative comparisons were made with existing diffusion data, and a particular attention is given to the anisotropy of the diffusion tensors at both the mesoscopic and macroscopic scales.
Photocatalytic degradation of polyethylene and polystyrene microplastics by α-Fe2O3/g-C3N4
Authors: Chai Chao , Liang Hao , Yao Ruike , Wang Fangli , Song Ningning , Wu Juan , Li Yan
Published: August 2023

This study investigated the photodegradation of microplastics (MPs) by α-Fe2O3/g-C3N4. The effects of α-Fe2O3/g-C3N4 on MPs' surface were investigated through various techniques. With the addition of α-Fe2O3/g-C3N4 and under visible light irradiation, cracks and folds were observed on the MP films and particles. Compared to the treatment without photocatalyst addition, the mass loss of MPs increased with irradiation time when α-Fe2O3/g-C3N4 was added. Specifically, polystyrene films and particles in water showed 9.94% and 7.81% increased mass loss, respectively. The degradation of MPs using α-Fe2O3/g-C3N4 demonstrated the behavior consistent with the pseudo-first-order kinetic model. The presence of α-Fe2O3/g-C3N4 led to an increase in surface oxygen-containing functional groups and crystallinity while decreasing the average molecular weight of MPs. After 30 days of irradiation, the characteristic tensile bands of MPs with α-Fe2O3/g-C3N4 significantly increased, and the detection of carboxyl bands indicated the formation of carboxylic acid, ketones, and lactones as degradation products.
Construction of a comprehensive predictive model for axillary lymph node metastasis in breast cancer: A retrospective study
Authors: Li Yan , Han Dong , Shen Cong , Duan Xiaoyi
Published: August 2023

Purpose
The accurate assessment of axillary lymph node metastasis (LNM) in early stage breast cancer (BC) is of great importance. This study aimed to construct an integrated model based on clinicopathology, ultrasound, PET/CT, and PET radiomics for predicting axillary LNM in early stage BC.
Materials and Methods
124 BC patients who underwent 18F-fluorodeoxyglucose (18F-FDG) PET/CT and whose diagnosis were confirmed by surgical pathology were retrospectively analyzed and included in this study. Ultrasound, PET and clinicopathological features of all patients were analyzed, and PET radiomics features were extracted to establish an ultrasound model (clinicopathology and ultrasound; model 1), a PET model (clinicopathology, ultrasound, and PET; model 2), and a comprehensive model (clinicopathology, ultrasound, PET, and radiomics; model 3), and the diagnostic efficacy of each model was evaluated and compared.
Results
The sensitivity was 48.57%, 88.57%, and 82.86%, the specificity was 88.76%, 68.54%, and 82.02%, and the AUC was 0.686, 0.823, and 0.874 for models 1, 2, and 3, respectively.
Conclusion
The use of an comprehensive model based on clinicopathology, ultrasound, PET/CT, and PET radiomics can effectively improve the diagnostic efficacy of axillary LNM in BC.
Dynamics of a cantilevered fluid-conveying straight pipe with centrosymmetric rib plates installed at its fixed end
Authors: Zhao Qianli , Cai Fuhai , Yu Wenwu , Liu Jinwu
Published: August 2023

Rib plates are often used for improving load-bearing capacity, to study the influences of centrosymmetric rib plates installed at the fixed end on the dynamics of a cantilevered fluid-conveying straight pipe, the governing equation is deduced based on D’Alembert principle at first, during this process, the centrosymmetric rib plates are equivalently replaced by the combination of a series of linear and torsional springs whose stiffness coefficients are formulated according to thin plate bending theory. Then Galerkin method is used to discretize the above governing equation, where the shape functions are just the mode functions of cantilevered Euler-Bernoulli straight beam deduced by differential transformation method, the expressions of eigenfunction for flow-induced vibration and steady-state displacement response for forced vibration are obtained subsequently. Numerical experiments of a real water-supplying pipe are carried out, some conclusions never mentioned in published literatures are drawn. The same dynamic problems for other kinds of straight pipes and for curved pipes possessing one clamped end are also discussed. The investigation has reference meaning for optimal design of rib plates in aspects of geometric sizes and materials, also for optimal design of supporting formats of fluid-conveying pipes.
Exercise coupled with calorie restriction reduces SIRT1 and SIRT2 in female obese adolescents
Authors: Liu Jun , He Yanan , Mao Caifeng , Su Hang , Gao Zhiqiang , Zou Xiaoyu , Tang Lixu , Liao Ting , Xiong Xiaoling , Zhao Rumeng , Zhang Zihao , Li Chunyan
Published: August 2023

Background:
As exercise coupled with calorie restriction was a most effective method for long-term weight control, whether exercise coupled with calorie restriction controls the expression of SIRT1 and SIRT2 and how the mechanisms work become important. Long-term benefits of conservative treatments in obese adolescents are limited, except for exercise training. Exercise training coupled with calorie restriction as a most effective method for long-term weight control has become increasingly considerable.
Methods:
Statistical significance for serum biomarkers associated with fat etabolism and longevity measured before and after intervention was evaluated using a paired sample t-test. Correlation coefficients were used to examine the relationships between fat metabolism and longevity biomarkers and physical composition parameters.
Results:
Physical composition parameters revealed a significant decline after 4-week intervention involving in exercise training coupled with calorie restriction(p < 0.05). Exercise coupled with dietary restriction decreases circulating serum SIRT1 and SIRT2 levels(p< 0.05). Circulating serum SIRT2 levels negatively correlate with vital capacity before 4-week intervention(p < 0.05). Circulating serum IGF1/IGFBP3 levels positively correlate with vital capacity after 4-week intervention(p < 0.05).
Conclusions:
4-week exercise training and calorie restriction may upregulate Sirt1 gene expression in nucleus and downregulate mRNA translation in cytoplasm,which in turn, reduced circulating Sirt1 and Sirt2.
Integrated Predictive Analysis for Periodontal Disease and Malocclusion Detection in Dentistry using Deep Learning and CNN-based Decision Making
Authors: M Naresh Kumar , TK Lakshmi , SLAVAKKAM DILLI BABU , Ch Ramesh Babu , Pamula Rajendra
Published: August 2023

The complete digitalization of the healthcare industry, particularly in the field of dentistry, is necessary to ensure timely and accurate diagnoses, effective patient management, and reliable predictive capabilities. Untreated oral conditions have the potential to cause significant discomfort and harm to the teeth. This study suggests employing digitalization and machine learning classifiers as a potential solution to mitigate the effects of Periodontitis. Effective decision-making is a critical aspect of dentistry, particularly in the areas of treatment planning, management, and chairside efficiency. The application of computer resources and technologies is being optimised through the gradual replacement of manual processes with computer-assisted decision-making, thereby ensuring effectiveness and efficiency. The utilisation of artificial intelligence and virtual reality has led to notable advancements in disease detection, identification, diagnosis, pre- and post-treatment planning, patient management, and computer-assisted surgeries. The present study suggests the utilisation of convolutional neural networks (CNN) as a potential solution to tackle the issue of malocclusion, a condition that results in anomalous positioning of teeth and jaws, thereby impacting the facial appearance during smiling. This work we employ a multi-factor analysis (MFA) model, cross-validation techniques, feature extraction, and ensemble learning to conduct predictive analysis on chronic localised and chronic generalised periodontitis. The study developed a dataset comprising of 1000 patients, and assessed the classification accuracies of various classifiers including Naïve Bayes, Support Vector Machine, Random Forest, Logistic Regression, K Nearest Neighbours, and Decision Tree. The obtained accuracies were 95.5%, 100%, 100%, 100%, 99.5%, and 99%, respectively. Orthodontic treatments are a viable solution for correcting misalignment. The dataset utilised in this study comprises of RGB images depicting patients' teeth exhibiting malocclusion as well as those with properly aligned teeth. The CNN algorithm was employed to differentiate between normal and malocclusion images, yielding a precision rate of 98.95%. The implementation of this technology has the potential to aid orthodontic professionals in making informed decisions and developing accurate treatment plans for the creation of aligners and the anticipation of tooth extraction requirements.
Exploring the Role of Phase Change Materials in Low-Temperature Solar Thermal Applications: An Extensive Overview with challenges and opportunities
Authors: Vasudevan Gopi , Muthuvairavan Guna , Suraparaju Subbarama Kousik , Yadav Aman , Samykano Mahendran , NATARAJAN SENDHIL KUMAR
Published: August 2023

Solar energy is widely acknowledged as a renewable and environmentally friendly energy source. Efficient storage of heat energy is a crucial challenge in solar thermal applications. Phase Change Materials (PCMs) have gained prominence due to their unique ability to store and release thermal energy through phase transition. The advantageous characteristic of PCMs is their low melting point, facilitating efficient heat storage and retrieval through latent heat of vaporization. This comprehensive review focuses on selecting suitable PCMs for diverse applications, considering their melting point and thermal properties. PCMs with high heat capacity and excellent solar radiation absorption are particularly favored in solar applications, especially for systems requiring large thermal energy storage (TES) capacities. In conclusion, this review underscores the importance of PCMs in solar energy applications, emphasizing their role in practical heat storage and release. By careful selection of PCMs based on melting point and thermal properties, the performance and efficiency of solar thermal systems can be optimized, contributing to a greener and more sustainable future.
Identification and Exploration of Novel Predictive Markers, Tumor-Related Biomarkers, in Preeclampsia
Authors: Yang Mei , Wang Menghui , Zhu Qing , Zhang Xin , Li Nanfang
Published: August 2023

Purpose:To explore whether significant differentially expressed genes (DEGs) in the blood circulation of preeclampsia patients can truly reflect placental function, predict the development of disease, and explain the pathogenesis of preeclampsia.Methods:The main method of our study is biological information technology.The microarray dataset GSE48424 was downloaded from the Gene Expression Omnibus (GEO) database. The DEGs were identified by GEO2R, and functional enrichment analyses were performed by the R package/a free online platform (https://www.bioinformatics.com.cn). The protein‒protein interaction network (PPI) was constructed, and module analysis was performed using STRING and Cytoscape. R language was used for the visualization of the results. GraphPad Prism was used to generate graphs. logFC (fold change) >0.58 and adj. P values<0.05 were considered statistically significant.Results:A total of 178 DEGs were obtained, consisting of 121 downregulated genes and 57 upregulated genes. Five hub genes were identified and considered to be significant according to scores calculated by Cytoscape. The enriched functions and pathways analysis revealed that these genes were mainly enriched in regulation of the ERK1 and ERK2 cascade. Differential expression ofTLR4,SMAD4,POU5F1,MAP2K1, andRAB1Awas significant in blood circulation and placental tissues of preeclampsia.Conclusion:TheTLR4,SMAD4,POU5F1,MAP2K1, andRAB1Agenes may be predicted targets to prevent preeclampsia development. Moreover, these genes could truly reflect placental function and nicely explain the pathogenesis of preeclampsia from a molecular biology perspective.
The effects of aerobic exercises compared to conventional chest physiotherapy on pulmonary function, functional capacity, sputum culture, and quality of life in children and adolescents with cystic fibrosis: a study protocol for randomized controlled trial study
Authors: Hamedi Nadia , Kajbafvala Mehrnaz , Shahali Shabnam , Pourahmadi Mohammadreza , Eshghi Alireza , Estahbanati Mohammadreza Modaresi
Published: August 2023

Background
Cystic Fibrosis (CF) is an autosomal recessive disorder caused by abnormal function of the chloride ion channel, and characterized by pancreatic insufficiency, and chronic endobronchial airway infection. Pulmonary dysfunction is very common and could lead to a reduction in the quality of life. Airway Clearance Techniques (ACT) and physical exercises are introduced as one of the main components of treatment. Therefore, it will be of interest to examine the effect of aerobic exercises compared to Conventional Physiotherapy (CPT) on pulmonary function, exercise capacity, functional capacity, sputum culture, and quality of life in patients with CF.
Methods
Thirty Patients with CF will participate in a double-blind parallel controlled trial containing 18 sessions of treatment. Group A consists of CPT and placebo aerobic exercise, and group B includes aerobic exercise and placebo CPT. Pulmonary function, functional capacity, sputum culture, and quality of life will be evaluated with a spirometry test, 6-minute walk test (6MWT), sputum culture test, and the Cystic Fibrosis Questionnaire-Revised (CFQ-R), respectively before and after the intervention.
Discussion
We will evaluate and compare the effectiveness of aerobic exercises and conventional chest physiotherapy on pulmonary function, functional capacity, sputum culture, and quality of life. Comparing these two treatment patterns can contribute to a better understanding of the effectiveness. Therefore, if there is a significant difference between two treatments, the superior treatment will be prioritized clinically.
Trial registration:
This trial is registered at https://www.irct.ir, under trial number IRCT20210505051181N5, approved at 2/19/2023.
A short and efficient Formal Synthesis of R-Pipecolic Acid from the Ring expansion of Chiral Aziridine
Authors: Pareek Archana , Khom Sonam Tashi , Saikia Pranjit , Yadav Nagendra Nath
Published: August 2023

Ring expansion of 4-(R)-1-(R)-1-phenylethyl)aziridin-2-yl)butyl 4-tosylate obtained from tosylation of 4-(R)-1-(R)-1-phenylethyl)aziridin-2-yl)butan-1-ol via formation of 1-azabicyclo[4.1.0]heptane tosylate gives substituted piperidine. The ring openings of azabicycloheptane tosylate with acetate nucleophiles proceeded in highly regio- and stereoselective manner with release of the ring-strain of the three-member aziridine ring through the breakage of either C-N bond. This ring expansion streategy of aziridine provides a short route for asymmetric synthesis of biologically active natural alkaloid such as R-Pipecolic acid.
The influence of placenta microbiota of normal term pregnant women on immune regulation during pregnancy
Authors: Yang Ping , Lu Tong , Liang Xinyuan , Huang Ting , Wu Lulu , He Zonglin , Xiao Xiaomin , fan shangrong
Published: August 2023

Background
The concerted regulation of placenta microbiota and the immune responses secures the occurrence and development of pregnancy, while few studies reported this correlation. This study aimed to explore the relationship between the placenta microbiota and immune regulation during pregnancy.
Methods
26 healthy pregnant women scheduled for elective cesarean section in the First Affiliated Hospital of Jinan University who met the inclusion criteria were recruited. Placenta and peripheral venous blood samples were collected. Microbiota in placental tissue was detected using high-throughput sequencing. Flow cytometry was used to detect immune cells in placental tissue and peripheral venous blood. ELISA and Luminex liquid chip technology were used to detect the content of cytokines in placental tissue and peripheral venous blood, respectively.
Results
The placental microbiota has stimulating effects on the local immunity of the placenta and mainly stimulates the placental balance ratio CD56 + CD16+/CD56 + CD16 and the placental macrophages, that is, it plays the role of immune protection and supporting nutrition. The stimulating effect of placental microbiota on maternal systemic immunity mainly induces peripheral Treg cells and B lymphocytes.
Conclusion
The placental microbiota may be an important factor mediating local immune regulation in the placenta, and placental microbiota participates in the regulatory function of the maternal immune system.