bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Dampak Sosial Media Terhadap Pendidikan Karakter Siswa Sekolah Dasar
Authors: Wahyudin Dede , Caturiasari Jennyta , Futri Elmalia , Puradireja Syifa Mutiara , Salsabila Maghfira
Published: February 2024

Perkembangan teknologi yang semakin melesat dan minimnya pendidikan digital bagi masyarakat membuat semua kalangan menggunakan social media dengan bebas tanpa edukasi. Dalam hal ini yang dikhawatirkan adalah para siswa yang masih duduk di usia sekolah dasar yang sudah menggunakan social media dengan bebas. Penelitian ini menggunakan metode kualitatif dengan jenis studi kasus. Sumber data utama dalam penelitian ini adalah artikel berita tentang anak sekolah dasar yang terpengaruh oleh sosial media sehingga berdampak pada perilaku dan pendidikan karakter anak, yang bersumber dari portal berita online di internet mengenai kasus tersebut. Hasil dari pembahasan kasus ini yakni kejadian tersebut berakhir damai secara kekeluargaan. Diluar itu, hal tersebut tentu tidak bisa dibenarkan, mau dilihat dari usiapun jika menimbulkan korban sama saja merupakan pembully-an, apalagi dengan alasan ingin viral.
Peningkatan Kedisiplinan Peserta Didik Melalui Model Pembelajaran Velue Clarification Technique Di Kelas IV Semester I SD Negeri Tingkir Tengah 02 Kota Salatiga Tahun Pelajaran 2023
Authors: Wikanti Yunda Arumi , Mawardi Mawardi
Published: February 2024

Penelitian ini bertujuan untuk meningkatkan kedisiplinan peserta didik kelas 4 SD Negeri Tingkir Tengah 02 Kota Salatiga tahun pelajaran 2023 dengan menggunakan tekni pembelajaran Velue Clarification Technique. Dalam penelitian ini menggunakan Penelitian Tindakan Kelas yang terdiri dari dua siklus. Penelitian ini menggunakan subjek peserta didik kelas IV Semester I di SD Negeri Tingkir Tengah 02 Kota Salatiga tahun ajaran 2023 dengan total 26 peserta didik. Teknik pengumpulan datanya yaitu dengan observasi, wawancara, dan dokumentasi. Teknik analisis data dengan menggunakan triangulasi teknik dan deskripsi. Siklus I menghasilkan presentase 38,46% secara klaksikal dan dilanjut penelitian Siklus II memperoleh hasil 80,77% secara klaksikal. Dari hasil analisis data dapat disimpulkan bahwa model pembelajaran menggunakan Velue Clarification Technique berhasil meningkatkan kedisiplinan peserta didik kelas IV Semester I di SD Negeri Tingkir Tengah 02 Kota Salatiga tahun pelajaran 2023.
Pengaruh Supervisi Akademik Kunjungan Kelas Terhadap Kompetensi Paedagogik Guru dalam Pengelolaan Kelas
Authors: Atun Siti Rupik
Published: February 2024

Tujuan penelitian ini adalah menganalisis ada-tidaknya pengaruh supervisi akademik teknik kunjungan kelas dan kekuatan pengaruhnya terhadap kompetensi pedagogik guru dalam pengelolaan kelas. Jenis penelitian ini adalah penelitian eksperimen. Tempat penelitian ini di SDN Kedungringin. Waktu penelitian ini pada bulan Februari hingga Mei tahun 2023. Variabel bebas (X) adalah supervisi akademik Kepala Sekolah dengan teknik kunjungan kelas. Variabel terikat (Y) adalah kompetensi pedagogik guru dalam pengelolaan kelas. Populasi sebanyak 8 orang guru. Alat pengumpulan data penelitian ini adalah kuesioner (angket). Teknik analisis data menggunakan Paired Sample t Test. Hasil penelitian ini adalah supervisi akademik teknik kunjungan kelas berpengaruh sangat kuat dan signifikan terhadap kompetensi pedagogik guru dalam pengelolaan kelas. thitung sebesar [-12,28] dengan signifikansi sebesar 0,000 yang lebih besar daripada ttabel (1,894). Kompetensi pedagogik guru dalam pengelolaan kelas sebelum perlakuan (Pretest) termasuk kategori cukup bagus (C). Kompetensi pedagogik guru dalam pengelolaan kelas setelah perlakuan (Posttest) termasuk kategori bagus (B).
PERAN GURU BIMBINGAN DAN KONSELING DALAM MEREDUKSI PERILAKU MEROKOK PESERTA DIDIK SEKOLAH MENENGAH PERTAMA DI SURAKARTA
Authors: Prakoso, S.Pd, M.Pd Muhammad Rizky Nur
Published: February 2024

Perilaku merokok merupakan tindakan negatif yang dapat merusak kesehatan dan menyebabkan polusi lingkungan, selain itu rokok juga merupakan sumber tindakan-tindakan negatif yang dapat memicu kenakalan remaja dan terhambatnya tugas perkembangan peserta didik. Salah satu peran guru Bimbingan dan Konseling (BK) adalah untuk memberikan bantuan dan memfasilitasi peserta didik yang mengalami permasalahan terkait dengan pencegahan perilaku merokok dan mereduksi/mengurangi perilaku negatif tersebut. Penelitian yang dilaksanakan menggunakan metode deskriptif kuantitatif. Teknik analisis data menggunakan hasil validitas isi dengan menggunakan formula Aiken. Hasil penelitian menunjukkan bahwa peran guru BK dan LKPD yang digunakan dalam pemberian layanan Bimbingan Klasikal dihasilkan 87,76%, dengan kategori sangat baik. Kesimpulan dari penelitian ini adalah  peran guru BK dalam pemenuhan tugas perkembangan peserta didik remaja adalah sebagai pendamping atau fasilitator peserta didik dalam memenuhi hak dan kewajibannya, melalui upaya pencegahan dan kuratif/rehabilitasi yang dilaksanakan melalui konseling individu/kelompok.

Kata Kunci: Peran Guru Bimbingan dan Konseling, Perilaku Merokok, Konseling Individual
ПСИХОЛОГІЧНІ ОСОБЛИВОСТІ ЖИТТЄСТІЙКОСТІ СТУДЕНТІВ ВІЙСЬКОВОЇ КАФЕДРИ
Authors: Березовська Л. , Богайчук В.
Published: February 2024

У статті представлено теоретичний аналіз поняття «життєстійкість», огляд сучасних емпіричних зарубіжних та вітчизняних розвідок життєстійкості. Емпірично досліджено життєстійкість з використанням повної версії тесту життєстійкості С. Мадді та короткої версії тесту життєстійкості (В.О. Олефір, М.А. Кузнєцов, А.В. Павлова). Розглянуто особливості життєстійкості та її параметрів у студентів військової кафедри.
Sarcoidosis Masquerading as Miliary Tuberculosis: A Case Report
Authors: Abdelmaseeh Tony , Shah Rakesh , Sobuto John , Frank Renee , Archambault Steven
Published: February 2024

A miliary nodular pattern of the lungs is an unusual presentation of sarcoidosis. Diagnosis of this condition can be challenging and requires exclusion of other lung pathology.
A 47-year-old African American male presented to his doctor with a complaint of unintentional weight loss, exertional dyspnea and cough. The patient had a history of chronic smoking as well as recent incarceration. A miliary nodular pattern was found on CT scan of the lungs in a random distribution (with prominent peri-lymphatic distribution). HIV was ruled out. Tuberculosis (TB) and fungal infections were ruled out by tissue specimens and cultures from bronchoalveolar washings. Non-caseating granulomas on tissue specimens, peripheral smear lymphopenia and an elevated angiotensin converting enzyme (ACE) level were the positive findings on pathology and labs. The patient responded to a tapering course of oral steroids.
This case demonstrates one of the unusual clinical presentations of sarcoidosis. Sarcoidosis is an autoimmune condition with predilection for middle aged African American patients.
Training of library and information personnel in the context of the digital transformation of the library industry in Vietnam: Case study of the Center for Libraries and Digital Knowledge of Hanoi National University
Authors: Kim Dung Nguyen Thi
Published: February 2024

The author analyzes and evaluates the current situation with training library and information personnel at the Center for Libraries and Digital Knowledge of Vietnam National University (Hanoi) in the context of the digital transformation of the library industry in Vietnam. The following issues are highlighted: the role of library and information personnel in the digital transformation of the library industry; application of the ASK model (attitude, skills, knowledge) to analyze the current situation with information and library human resources at the Center for Libraries and Digital Knowledge of the Vietnam National University, Hanoi. The statistically reliable data evidence on the imbalance of three main components of the planned program: the level of professional library training for the implementation of the goals is generally sufficient; the qualifications of employees in the field of new information technologies look weaker. Third, the librarians’ practical knowledge of foreign languages is of particular concern, which is essential for real digital transformation of libraries. The author offers assessments and recommendations to improve the training of library personnel capable and to meet the requirements of the digital transformation of the library industry in Vietnam.
Isatuximab-pomalidomide-dexamethasone versus pomalidomide-dexamethasone in patients with relapsed and refractory multiple myeloma: final overall survival analysis
Authors: Richardson Paul G. , Perrot Aurore , Miguel Jesus San , Beksac Meral , Spicka Ivan , Leleu Xavier , Schjesvold Fredrik , Moreau Philippe , Dimopoulos Meletios A. , Huang Shang-Yi , Minarik Jiri , Cavo Michele , Prince H. Miles , Macé Sandrine , Zhang Rick , Dubin Franck , Morisse Mony Chenda , Anderson Kenneth C.
Published: February 2024

The primary and pre-specified updated analyses of ICARIA-MM (NCT02990338) demonstrated improved progression-free survival and a benefit in overall survival (OS) was reported with the addition of isatuximab, an anti-CD38 monoclonal antibody, to pomalidomide–dexamethasone (Pd) in patients with relapsed/refractory multiple myeloma. Here, we report the final OS analysis. This multicenter, randomized, open-label, phase 3 study included patients who had received and failed ≥2 previous therapies, including lenalidomide and a proteasome inhibitor. Between January 10, 2017, and February 2, 2018, 307 patients were randomized (1:1) to isatuximab–pomalidomide– dexamethasone (Isa-Pd; n = 154) or Pd (n = 153), stratified based on age (3). At data cutoff for the final OS analysis after 220 OS events (January 27, 2022), median follow-up duration was 52.4 months. Median OS (95% confidence interval) was 24.6 months (20.3–31.3 months) with Isa-Pd and 17.7 months (14.4–26.2 months) with Pd (hazard ratio = 0.78; 95% CI, 0.59–1.02; 1-sided P = 0.0319). Despite subsequent daratumumab use in the Pd group and its potential benefit on PFS in the first subsequent therapy line, median PFS2 was significantly longer with Isa-Pd vs. Pd (17.5 vs. 12.9 months; log-rank 1-sided P = 0.0091). In this analysis, Isa-Pd continued to be efficacious and well tolerated after follow-up of approximately 52 months, contributing to a clinically meaningful, 6.9-month improvement in median overall survival in patients with relapsed/refractory multiple myeloma.
Xây dựng thang đo tổ chức học tập trong các doanh nghiệp Việt Nam
Authors: Tạ Huy Hùng , Bùi Quang Tuyến
Published: February 2024

Môi trường kinh doanh có sự thay đổi nhanh chóng, tổ chức cần xây dựng tổ chức học tập là một trong những cách thức giúp tổ xây dựng lợi thế cạnh tranh của tổ chức. Trong nghiên cứu này, tác giả xây dựng thang đo với tổ chức học tập để xác định các thành phần trong tổ chức học tập trong các doanh nghiệp Việt Nam để có thể xây dựng và duy trì lợi thế cạnh tranh thông qua nguồn lực tri thức trong tổ chức. Phương pháp nghiên cứu định lượng và định tính được thực hiện đã xác định các thành phần của tổ chức học tập ở các doanh nghiệp Việt Nam. Kết quả nghiên cứu làm căn cứ để các tổ chức xây dựng và hoàn thiện tổ chức học tập trong bối cảnh doanh nghiệp ngày càng phải đối mặt với nhiều thách thức từ môi trường kinh doanh.
Beras Analog: Inovasi sebagai Diversifikasi Pangan dan Peluang Peningkatan Pendapatan Desa Sumbersih Kabupaten Blitar
Authors: Zamrodah Yuhanin , Prayudhi Luhur Aditya , Sofiyana Marinda Sari , Winarti Sri , Suryanto Tri Lathif Mardi , Tranggono Didiek
Published: February 2024

Desa Sumbersih, Kabupaten Blitar, telah menjalani proyek pelibatan masyarakat yang bertujuan untuk meningkatkan produktivitas Kelompok Tani "Budi Daya" dan Karang Taruna "Bhakti Husada Pertiwi". Melalui program pengabdian masyarakat Kolaborasi Sosial Membangun Masyarakat (KOSABANGSA) ini melibatkan Universitas Islam Balitar (UNISBA) Blitar dan Universitas Pembangunan Nasional “Veteran” Jawa Timur (UPNVJT) dalam melaksanakan program pengabdian terlebih dahulu berupa observasi dan wawancara, selanjutnya ceramah mengenai proses pembuatan beras analog dan tahapan teakhir evaluasi keterampilan peserta dalam produksi beras analog. Tujuannya adalah untuk menciptakan diversifikasi umbi-umbian menjadi beras analog yang bernilai tinggi sehingga dapat menjadi opsi peningkatan pendapatan masyarakat setempat. Proyek ini melibatkan pengamatan dan wawancara dengan para petani, memberikan pelatihan praktis, dan menilai antusiasme serta keterampilan mereka dalam prosesnya. Hasilnya, kegiatan penyuluhan dan sosialisasi ini berhasil memberikan pengetahuan dan pemahaman terkait olahan umbi-umbian yang bernilai tinggi berupa beras analog. Adapun tindak lanjut dari pengabdian ini adalah pelatihan branding dan labeling, digital entrepreneur serta pembuatan web digital marketing denagn tujuan untuk  mempermudah dalam memasarkan produk beras analog ini.
Sistem Hidroganik pada Kelompok Wanita Tani guna Meningkatkan Hasil Panen dan Menunjang Ketahanan Pangan di Kawasan Perumahan
Authors: Setiyaningsih Lian Agustina , Widayati Sri , Sedyowati Laksni , Risqillah Muhammad Alwi , Sufiyanto  , Cahyaningsih Diyah Sukanti
Published: February 2024

Pengabdian ini bertujuan untuk meningkatkan hasil panen Kelompok Wanita Tani Cemara Hijau farm di Kota Malang dan menunjang ketahanan pangan di pemukiman perkotaan. Perpaduan antara komunitas perumahan, pemberdayaan, dan pertanian berkelanjutan menghadirkan jalan yang menarik untuk mengatasi permasalahan mendesak ini. Pemberdayaan masyarakat perumahan melalui penerapan hidroganik menawarkan pendekatan transformatif untuk mengatasi tantangan. Permaslahan mitra produksi penjualan sayur organic dan pemenujhan untuk warga perumahan. Metode pelaksanaannya melalui empat tahap yakni: identifikasi permasalahan dan kebutuhan, perancangan program, impelentasi dan evaluasi. Kegiatan yang dilakukan adalah pembuatan sistem hidroganik dan menjalankan penananm dengan media hdroganik. Kemudian melakukan pelatihan hidroganik agar hasil panen efektif. Seiring dengan semakin populernya praktik hidroganik di seluruh dunia, pengabdian ini menggarisbawahi peran pentingnya dalam meningkatkan ketahanan pangan, mendorong pertanian perkotaan berkelanjutan, dan mendorong pemberdayaan komunitas perumahan. Hasilnya mencerminkan potensi perluasan gerakan hidroganik untuk melibatkan lebih banyak penghuni perumahan dan mengatasi tantangan ketahanan pangan kontemporer.
IMPROVING TRAFFIC DENSITY PREDICTION USING LSTM WITH PARAMETRIC ReLU (PReLU) ACTIVATION
Authors: Alamsyah Nur , Yoga Titan Parama , Budiman Budiman
Published: February 2024

In the presence of complex traffic flow patterns, this research responds to the challenge by proposing the application of the Long Short-Term Memory (LSTM) model and comparing four different activation functions, namely tanh, ReLU, sigmoid, and PReLU. This research aims to improve the accuracy of traffic flow prediction through LSTM model by finding the best activation function among tanh, relu, sigmoid, and PReLU. The method used starts from the collection of traffic flow datasets covering the period 2015-2017 used to train and evaluate the LSTM model with the four activation functions. Tests were conducted by observing the Train Mean Squared Error (MSE) and Validation MSE. The experimental results show that PReLU provides the best results with a Train MSE of 0.000505 and Validation MSE of 0.000755. Although tanh, ReLU, and sigmoid provided competitive results, PReLU stood out as the optimal choice to improve the adaptability of the model to complex traffic flow patterns.
Baby steps forward on the pathway towards improvement of neonatal care
Authors:   , de Bijl-Marcus Katharina Adriana
Published: February 2024

The thesis “baby steps forward on the path towards improvement of neonatal care” delves into the concept of "value" in neonatal intensive care. It discusses the definition of “value”, its measurement, and whether stakeholders share a common understanding. The thesis explores a value-based approach, aiming for optimal patient outcomes and efficient resource utilization. It emphasizes that the value of neonatal care extends beyond immediate results to encompass long-term quality of life and societal impact.

Measuring outcomes is crucial for improving value. It provides insights, guides patient- and parent/family-centered care, and has the potential to transform healthcare systems. The first section of the thesis includes studies on neonatal outcomes, such as acute kidney injury and hospitalization duration. The second part explores strategies to improve neonatal outcomes, including therapeutic hypothermia following lack of oxygen around birth in term infants or interventions to prevent brain hemorrhage in preterm infants. The third section considers safety and perception of quality of care from the perspectives of healthcare professionals and parents.

The thesis concludes by addressing challenges and recommending future research directions, such as balancing stakeholder perspectives and transitioning to value-based payment models. In summary, this thesis advocates a collaborative, patient- and family-centered approach to neonatal intensive care, with a focus on outcome measurement, care improvement, and adding value to interactions between parents and caregivers. It encourages individual care professionals, teams and organizations to reflect on how they can contribute to enhancing “value” in patient care.
A pancreassztentek helye és jelentősége a poszt-ERCP pancreatitis kivédésében
Authors: Dubravcsik Zsolt , Novák Péter , Nacsev Krisztián , Hritz István , Madácsy László
Published: February 2024

Az endoszkópos retrográd cholangiopancreatographia (ERCP) leggyakoribb szövődménye a poszt-ERCP pancreatitis, amelynek számos kockázati tényezője és megelőzésének lehetőségei is ismertté váltak az elmúlt bő három évtizedben. A magas rizikójú betegcsoportban a kis kaliberű, ún. profilaktikus pancreassztentek (PPS) bizonyulnak a leghatékonyabb megelőző eljárásnak, bár használatukhoz megfelelő endoszkópos gyakorlat szükséges. Jelen publikációban a PPS-ekkel kapcsolatos ismeretanyagot foglaltuk össze.
Top of Basilar syndrome
Authors: Demir Bilgehan
Published: February 2024

Top of Basilar syndrome(BTS) is defined as ischemia of the areas fed by the distal basilar artery (brainstem, thalamus, cerebellum, temporal and occipital region). It shows many different symptoms. Usually visual and oculomotor disorders, changes of mind, speech disorders, seizures and hallucinations are observed. Beginning symptoms include epileptic seizures, decreased speech and inappropriate laughter, and hallucinations. This our article is that prensentation of neurological analysis in the management of cases with sudden behavioral disorders. A patient diagnosed with BTS with rare symptoms is presented. Clinicians need to be careful about BTS, which has symptoms such as sudden mood swings, personality changes and behavioral disorders
ANALISIS EFEKTIVITAS BIAYA BEBERAPA MOISTURIZER
Authors: Dasopang Eva Sartika , Hasanah Fenny , Siahaan Desy Natalia , Salsabila Putri
Published: February 2024

The growth of e-commerce continues to increase in Indonesia, one of which is the Shopee application which can buy goods, sell various kinds of products, and shop safely. Shopee showed in early 2020 that the beauty category ranked highest in the best-selling product categories, one of which was Moisturizer. The purpose of this study was to determine the comparison of each moisturizer which is more cost effective. This type of research uses a true experimental method with a posttest only control group design to determine the before and after conditions between the control group (no moisturizer) and the experimental group (moisturizer X, moisturizer Y, moisturizer Z). The sample of this study consisted of 20 volunteers with observations carried out for 4 weeks to obtain the effectiveness of moisture recovery, pores, blemishes, wrinkles. The results showed that moisturizer Z for moisture is more cost effective with an ACER value of Rp. 859 ICER Rp. 886. While moisturizer Y for pores is more cost effective with an ACER value of Rp. 2,515 ICER Rp. 2,800. While moisturizer Y for blemishes is more cost effective with an ACER value of Rp. 2,427.7 ICER Rp. 2,581. Then moisturizer Z for wrinkles is more cost effective with an ACER value of Rp. 1,846 ICER Rp. 2,307. In conclusion, moisturiser C is the most cost effective for moisture and wrinkles while moisturiser B is more cost effective for pores and blemishes.
Collective Memory and Democratic Mobilization: Insights from Chile's Constitutional Revolution (2019-2023)
Authors: Martins Armando
Published: February 2024

This article investigates the enduring impact of historical-political tragedies on current political behavior, focusing on Chile's ``Estallido Social" protests (2019-2020) and the Constituent Plebiscite (2020-2023). Utilizing social media data to analyze political memory, the study contends that protests serve as a strategic engagement tool in municipalities with vivid recollections of past violence, such as Chile's era of institutional violence under Pinochet. LS analyses indicate that Chilean municipalities with pre-1970 military bases experienced heightened protest activity but showed reduced involvement in constitutional voting, without a clear lean towards any political coalition. The 2SLS estimations link this phenomenon to the long-term effects of political victimization during Pinochet's regime and the social media remembrance on the 1973 coup violence. The evidence suggests that while collective memories on political violence may encourage active protest participation, it can also weaken the relationship between voters and political elites, influencing voting behavior.
ROLE OF THE VORONEZH EXPERIMENTAL STATION FOR PERENNIAL HERBS – A BRANCH OF THE FEDERAL WILLIAMS RESEARCH CENTER OF FORAGE PRODUCTION AND AGROECOLOGY IN BREEDING AND PRIMARY SEED PRODUCTION OF PERENNIAL GRASSES IN RUSSIA
Authors: Saprykin Sergey , Saprykina Natal'ya , Lyubtseva Olga , NEMENUSchAYa Evgeniya
Published: February 2024

The main stages of development and main achievements in the field of breeding and seed production of forage crops of the Voronezh Experimental Station on perennial grasses are considered in the article. The main characteristics of the varieties created by the scientists of the station for 15 years are given. The process of creation, multiplication and introduction into production of intensive grass varieties of new generation, distinguished by a wide amplitude of resistance to abiotic and biotic factors, high productivity and increased environment-forming function is analysed. The necessity of development of fodder base of cattle breeding in the steppe zone of the Central Black Earth region on the basis of selection work with promising drought-resistant species: crested wheat grass, yellow alfalfa and sandy sainfoin.
FRISSON NO OLHO, GUERRA ENTRE OS DENTES
Authors: Dos Santos Stefano Lopes
Published: February 2024

Resenha crí­tica do curta-metragem recifense "Swinguerra" , dirigido por Benjamin de Burca e Bárbara Wagner e lançado mundialmente em 2019, que resulta de uma pesquisa acerca de manifestações culturais locais. O filme retrata os ensaios de grupos variados para uma competição anual de dança focada em swingueira, um fenômeno cultural majoritariamente periférico.
REPRESENTAÇÕES DA NOÇÃO DE "OBRA DE ARTE" NO PROGRAMA DE TV "WORK OF ART"
Authors: Braga Jr Amaro Xavier
Published: February 2024

O trabalho discute a problematização do conceito de "Obra de Arte" , na arte contemporânea, no programa de TV e reality show exibido no Brasil "Work of Art: The Next Great Artist" . A partir de uma hermêutica dos conteúdos, analisa os episódios da primeira temporada, confrontando a atuação dos artistas convidados, suas obras e as crí­ticas dos avaliadores no processo de construção da definição do que é "uma boa obra de arte" . Problematiza a questões do programa veicular uma definição de obra de arte para o público em geral. Teoricamente, toma como base a Teoria Institucional da Arte de Howard Becker em cruzamento com outros autores que discutem a definição de obra de arte. Finaliza, enfatizando como o programa delimita o que é arte e o que não é arte, não a partir da obra em si ou nas credenciais do artista, mas no consenso da comunidade que circunda os artistas: curadores, crí­ticos, marchands e galeristas.
PARA ALÉM DOS LIMITES DO DIZÍVEL: A EXPERIÊNCIA DO CORPO EM UMA EDUCAÇÃO INCLUSIVA
Authors: Machado Vinicius Torres , Paiva Giovanna Galisi
Published: February 2024

O presente artigo discute a necessidade de incluir a diversidade de experiências dos corpos na educação. A partir da década de 70 estudos sobre a experiência do sujeito impactaram os espaços de produção de conhecimento, contexto que foi nomeado por Beatriz Sarlo (2002) como "guinada subjetiva" . Também mais recentemente, os estudos decoloniais apontam como o discurso da história dominante da colonização encobriu a perspectiva dos povos colonizados. A vontade de dar voz a diferentes sujeitos e suas experiências são fundamentais para algumas correntes de pensamento contemporâneas. Muitas vezes esta voz é pensada a partir da narração, mas o trauma gerado por processos de violência exprime uma realidade que, por vezes, não encontra palavras que a representem. É neste limite do dizí­vel que o corpo carrega a dimensão real do acontecimento. Para uma educação inclusiva, os autores propõem pensar a sala de aula como um espaço de criação que compreenda os estudantes como seres integrados, priorizando a experiência do corpo como forma de conhecimento. O artigo reflete sobre a importância dos espaços de silêncio (Hooks, 2017) que aproxima o caráter indizí­vel e irrepresentável das experiências traumáticas do processo pedagógico.
FLOREIO NA CAPOEIRA: ENCANTAMENTO E DESENCANTAMENTO
Authors: Pasqua Lívia de Paula Machado
Published: February 2024

Um dos maiores desafios para bailarinos-pesquisadores-intérpretes, ou estudiosos-jogadores, no caso especí­fico da Capoeira, é a tradução de suas pesquisas sobre saberes corporais para o formato de um texto acadêmico. Tratar sobre o floreio da Capoeira está para além do gesto acrobático visí­vel, implica em compreender a complexidade desse objeto de estudo, as trajetórias desse saber corporal bem como o seu lado sensí­vel e intangí­vel. Assim, este ensaio tem como objetivo demonstrar como pude jogar-dançar-lutar com a minha tese de doutorado intitulada "Capoeira e diáspora africana: uma interpretação sobre os floreios" e como floreei com a minha pesquisa capoeiristicamente. A partir de mensagens-texto escritos por uma personagem fictí­cia, a rainha Nzinga, diluí­das na tese, foi possí­vel alimentar o lado sensí­vel desse objeto de estudo, por meio de encantamentos e desencantamentos ocorridos na trama, preparando a pessoa leitora para a compreensão do texto da pesquisa. Assim, mediante essa estratégia, foi possí­vel refletir sobre o contexto da diáspora africana, a migração forçada de pessoas escravizadas, as armas necessárias para combater a opressão, a luta e a resistência, a complexidade de diferentes estéticas ancestrais presentes na gestualidade da Capoeira e a beleza e encanto expresso pelo floreio, pelo florear e pelo floreado.
CORPO, LINGUAGEM E GESTO CRIATIVO – PROCESSOS DE COMUNIC[AÇÃO] EM COMPUTER-DANCE
Authors: Wosniak Cristiane do Rocio
Published: February 2024

o artigo é estruturado a partir de uma leitura reflexiva, analí­tica e contextual sobre os processos/gestos singulares de criação de uma artista brasileira – Analivia Cordeiro – dando ênfase a uma obra especí­fica de sua autoria: a computer-danceM3X3(1973). A partir da ideia de inacabamento, tenho por objetivo atualizar, revisar e dialogar com uma produção teórica e analí­tica realizada em 2006, a partir de minha dissertação de mestrado. Trago para este momento novas instâncias comunicativas do processo de criação da obra. A metodologia de análise se debruça sobre os pressupostos da Teoria Geral dos Signos de Charles Sanders Peirce. Os resultados de tal empreitada atualizam os sentidos e os processos de uma leitura polissêmica.
OS AFETOS E A BELEZA DE ÉRIC ROHMER
Authors: Gloria Lidia Maria Antunes
Published: February 2024

Trata-se de uma resenha crí­tica da segunda edição do livro Contos morais e o cinema de Éric Rohmer, do autor Alexandre Rafael Garcia, publicado em 2021 pela Editora A quadro (Curitiba, PR) contendo três capí­tulos. O livro é resultado da dissertação defendida no Programa de Pós-graduação em Artes do Instituto de Artes da Universidade Estadual de Campinas.
PRÁTICAS DE DIÁLOGO E ESCUTA PARA CRIAR-ENSINAR-APRENDER DANÇA EM COLETIVO: REFLEXÕES SOBRE A EXPERIÊNCIA NO ESTÁGIO SUPERVISIONADO II DO CURSO DE BACHARELADO E LICENCIATURA EM DANÇA DA UNESPAR- CAMPUS CURITIBA II
Authors: Tomaz Bruna Ramos , Setúbal Fernanda Goya , Vargas Nara Corrêa , Roel Renata Santos
Published: February 2024

Neste artigo relatamos as experiências vividas no Estágio Supervisionado em Dança II do curso de Bacharelado e Licenciatura em Dança da UNESPAR - Campus CURITIBA II durante o primeiro semestre do ano de 2021. Adentrar os encontros do grupo Nós de Dança do municí­pio de Sobral - CE ampliou a percepção e trouxe pistas para discutir práticas artí­stico-educacionais em dança que exercitam tentativas de relações horizontais e democráticas. No decorrer do processo, foi urgente reinventar as práticas pedagógicas devido à pandemia da Covid-19, e neste percurso constatou-se a urgência da escuta e do diálogo nos encontros e a afirmação de criar-ensinar-aprender dança a partir dos tensionamentos e construção de ví­nculos. As articulações conceituais aqui expostas se tecem da composição e fricção com as vozes de artistas e pesquisadores do campo da dança, educação e psicanálise, des integrantes do grupo Nós junto das anotações sensí­veis do campo de estágio.
In vitro evaluation of the osteogenic and antimicrobial potential of porous wollastonite scaffolds impregnated with ethanolic extracts of propolis
Authors: Moreno Florez Ana Isabel , Malagon Sarita , Ocampo Sebastian , Leal-Marin Sara , Ossa Edgar Alexander , Glasmacher Birgit , Garcia Claudia , Pelaez-Vargas Alejandro
Published: February 2024

Context: The development of porous devices using materials modified with various natural agents has become a priority for bone healing processes in the oral and maxillofacial field. There must be a balance between the proliferation of eukaryotic and the inhibition of prokaryotic cells to achieve proper bone health. Infections might inhibit the formation of new alveolar bone during bone graft augmentation.

Objective: This study aimed to evaluate the in vitro osteogenic behavior of human bone marrow stem cells and assess the antimicrobial response to 3D-printed porous scaffolds using propolis-modified wollastonite.

Methodology: A fractional factorial design of experiments was used to obtain a 3D printing paste for developing scaffolds with a triply periodic minimal surface (TPMS) gyroid geometry based on wollastonite and modified with an ethanolic propolis extract. The antioxidant activity of the extracts was characterized using free radical scavenging methods (DPPH and ABTS). Cell proliferation and osteogenic potential using Human Bone Marrow Stem Cells (bmMSCs) were assessed at different culture time points up to 28 days. MIC and inhibition zones were studied from single strain cultures, and biofilm formation was evaluated on the scaffolds under co-culture conditions. The mechanical strength of the scaffolds was evaluated.

Results: Through statistical design of experiments, a paste suitable for printing scaffolds with the desired geometry was obtained. Propolis extracts modifying the TPMS gyroid scaffolds showed favorable cell proliferation and metabolic activity with osteogenic potential after 21 days. Additionally, propolis exhibited antioxidant activity, which may be related to the antimicrobial effectiveness of the scaffolds against S. aureus and S. epidermidis cultures. The mechanical properties of the scaffolds were not affected by propolis impregnation.

Conclusion: These results demonstrate that propolis-impregnated porous wollastonite scaffolds might have the potential to stimulate bone repair in maxillofacial tissue engineering applications.
MXene: A wonderful nanomaterial in antibacterial
Authors: Ye Surong , Zhang Huichao , Lai Huiyan , Xu Jingyu , Yu Ling , Ye Zitong , Yang Luyi
Published: February 2024

Increasing bacterial infections and growing resistance to available drugs pose a serious threat to human health and the environment. Although antibiotics are crucial in fighting bacterial infections, their excessive use not only weakens our immune system but also contributes to bacterial resistance. These negative effects have caused doctors to be troubled by the clinical application of antibiotics. Facing this challenge, it is urgent to explore a new antibacterial strategy. MXene has been extensively reported in tumor therapy and biosensors due to its wonderful performance. Due to its large specific surface area, remarkable chemical stability, hydrophilicity, wide interlayer spacing, and excellent adsorption and reduction ability, it has shown wonderful potential for biopharmaceutical applications. However, there are few antimicrobial evaluations on MXene. The current antimicrobial mechanisms of MXene mainly include physical damage, induced oxidative stress, and photothermal and photodynamic therapy. In this paper, we reviewed MXene-based antimicrobial composites and discussed the application of MXene in bacterial infections to guide further research in the antimicrobial field.
Twenty years of explosive-effusive activity at El Reventador volcano (Ecuador) recorded in its geomorphology
Authors: Vallejo Silvia , Diefenbach Angela K. , Gaunt H. Elizabeth , Almeida Marco , Ramón Patricio , Naranjo Fernanda , Kelfoun Karim
Published: February 2024

Shifts in activity at long-active, open-vent volcanoes are difficult to forecast because precursory signals are enigmatic and can be lost in and amongst daily activity. Here, we propose that crater and vent morphologies, along with summit height, can help us bring some insights into future activity at one of Ecuador’s most active volcanoes El Reventador. On 3 November 2002, El Reventador volcano experienced the largest eruption in Ecuador in the last 140 years and has been continuously active ever since with transitions between and coexistence of explosive and effusive activity, characterized by Strombolian and Vulcanian behavior. Based on the analysis of a large dataset of thermal and visual images, we determined that in the last 20 years of activity, the volcano faced three destructive events: A. Destruction of the upper part of the summit leaving a north-south breached crater (3 November 2002), B. NE border crater collapse (2017), and C. NW flank collapse (2018), with two periods of reconstruction of the edifice: Period 1. Refill of the crater (2002-early 2018) and Period 2. Refill of the 2018 scar (April 2018–December 2022). Through photogrammetric analysis of visual and thermal images acquired in 11 overflights of the volcano, we created a time-series of digital elevation models (DEMs) to determine the maximum height of the volcano at each date, quantify the volume changes between successive dates, and characterize the morphological changes in the summit region. We estimate that approximately 34.1x106 m3 of volcanic material was removed from the volcano due to destructive events, whereas 64.1x106 m3 was added by constructive processes. The pre-2002 summit height was 3,560 m and due to the 2002 eruption it decreased to 3,527 m; it regained its previous height between 2014 and 2015 and the summit crater was completely filled by early April 2018. Event A resulted from an intrusion of magma that erupted violently; we proposed that Events B and C could be a result of an intrusion as well but may also be due to a lack of stability of the volcano summit which occurs when it reaches its maximum height of approximately 3,590 and 3,600 m.
Divergent path: isolating land use and climate change impact on river runoff
Authors: Mahmood Saqib , Khan Afed Ullah , Babur Muhammad , Ghanim Abdulnoor A. J. , Al-Areeq Ahmed M. , Khan Daud , Najeh Taoufik , Gamil Yaser
Published: February 2024

Water resource management requires a thorough examination of how land use and climate change affect streamflow; however, the potential impacts of land-use changes are frequently ignored. Therefore, the principal goal of this study is to isolate the effects of anticipated climate and land-use changes on streamflow at the Indus River, Besham, Pakistan, using the Soil and Water Assessment Tool (SWAT). The multimodal ensemble (MME) of 11 general circulation models (GCMs) under two shared socioeconomic pathways (SSPs) 245 and 585 was computed using the Taylor skill score (TSS) and rating metric (RM). Future land use was predicted using the cellular automata artificial neural network (CA-ANN). The impacts of climate change and land-use change were assessed on streamflow under various SSPs and land-use scenarios. To calibrate and validate the SWAT model, the historical record (1991–2013) was divided into the following two parts: calibration (1991–2006) and validation (2007–2013). The SWAT model performed well in simulating streamflow with NSE, R2, and RSR values during the calibration and validation phases, which are 0.77, 0.79, and 0.48 and 0.76, 0.78, and 0.49, respectively. The results show that climate change (97.47%) has a greater effect on river runoff than land-use change (2.53%). Moreover, the impact of SSP585 (5.84%–19.42%) is higher than that of SSP245 (1.58%–4%). The computed impacts of climate and land-use changes are recommended to be incorporated into water policies to bring sustainability to the water environment.
Terpenoids and membrane dynamics evolution
Authors: Hoshino Yosuke
Published: February 2024

Cellular membranes define the physical boundary of life and provide scaffolds for various fundamental metabolic activities, including ATP synthesis, respiration, phototrophy, endocytosis and ion transport. Terpenoids, also known as isoprenoids, are known to play important roles in membrane organization and regulation across the three domains of life through unique interactions with other membrane lipids and membrane proteins. Terpenoids are present in not only the membranes of the three domains, but also viral membranes and extracellular vesicles. The large structural diversity of terpenoids and their ubiquitous distribution in modern organisms make terpenoids distinct from other membrane lipids, such as fatty acyls that are nearly absent in archaea. Addressing the biochemical and biophysical properties that allow terpenoids to play critical roles in membrane organization is important to understand the driving forces that shaped cellular life as we know it. This review summarizes the major classes of terpenoids that are involved in membrane organization and discuss the impact of terpenoid-membrane interactions on the evolutionary trajectory of membrane dynamics and the fitness of host organisms.
Revolutionizing in vivo therapy with CRISPR/Cas genome editing: breakthroughs, opportunities and challenges
Authors: Macarrón Palacios Arturo , Korus Patrick , Wilkens Bodo G. C. , Heshmatpour Najmeh , Patnaik Sarita R.
Published: February 2024

Genome editing using the CRISPR/Cas system has revolutionized the field of genetic engineering, offering unprecedented opportunities for therapeutic applications in vivo. Despite the numerous ongoing clinical trials focusing on ex vivo genome editing, recent studies emphasize the therapeutic promise of in vivo gene editing using CRISPR/Cas technology. However, it is worth noting that the complete attainment of the inherent capabilities of in vivo therapy in humans is yet to be accomplished. Before the full realization of in vivo therapeutic potential, it is crucial to achieve enhanced specificity in selectively targeting defective cells while minimizing harm to healthy cells. This review examines emerging studies, focusing on CRISPR/Cas-based pre-clinical and clinical trials for innovative therapeutic approaches for a wide range of diseases. Furthermore, we emphasize targeting cancer-specific sequences target in genes associated with tumors, shedding light on the diverse strategies employed in cancer treatment. We highlight the various challenges associated with in vivo CRISPR/Cas-based cancer therapy and explore their prospective clinical translatability and the strategies employed to overcome these obstacles.
New views on price-making markets and the capitalist impulse: beyond Polanyi
Authors: Blanton Richard E. , Feinman Gary M.
Published: February 2024

Anthropologists have persistently diminished the importance of the market and marketplace exchange in premodern, preindustrial times. This strident anti-market mentality, derived largely from the writings of Karl Polanyi, underpins an ideological and politicized argument that neither sets useful guideposts to advance anthropological research, nor does it yield the necessary insights or empirically valid foundations to comprehend the deep historical origins of modern economies or polities. In fact, by envisioning the past that is categorically caged from the modern, the school of thought crystalized through Polanyi's perspectives circumvents the role of diachronic processes that are at the heart of a truly historical social science. Although it is not our principal aim to relitigate the vast literature pertaining to the rise and fall of Polanyian thought, our approach expands on prior arguments about his project both by highlighting critical perspectives on capitalism that long predated Polanyian thought and by identifying a veritable bounty of new evidence and theory concerning premodern and contemporary marketplace economies that enable us to transcend these now-entrenched claims. The scheme we present that distinguishes between open and competitive marketplaces, on the one hand, and the capitalist impulse, on the other, we believe, adds depth and breadth to the analysis of price-making markets and their divergent social and economic outcomes across time and space.
A review of natural products targeting tumor immune microenvironments for the treatment of lung cancer
Authors: Yao Pengyu , Liang Su , Liu Zhenying , Xu Cuiping
Published: February 2024

Lung cancer (LC) produces some of the most malignant tumors in the world, with high morbidity and mortality. Tumor immune microenvironment (TIME), a component of the tumor microenvironment (TME), are critical in tumor development, immune escape, and drug resistance. The TIME is composed of various immune cells, immune cytokines, etc, which are important biological characteristics and determinants of tumor progression and outcomes. In this paper, we reviewed the recently published literature and discussed the potential uses of natural products in regulating TIME. We observed that a total of 37 natural compounds have been reported to exert anti-cancer effects by targeting the TIME. In different classes of natural products, terpenoids are the most frequently mentioned compounds. TAMs are one of the most investigated immune cells about therapies with natural products in TIME, with 9 natural products acting through it. 17 natural products exhibit anti-cancer properties in LC by modulating PD-1 and PD-L1 protein activity. These natural products have been extensively evaluated in animal and cellular LC models, but their clinical trials in LC patients are lacking. Based on the current review, we have revealed that the mechanisms of LC can be treated with natural products through TIME intervention, resulting in a new perspective and potential therapeutic drugs.
Sustained S-IgG and S-IgA antibodies to Moderna’s mRNA-1273 vaccine in a Sub-Saharan African cohort suggests need for booster timing reconsiderations
Authors: Serwanga Jennifer , Ankunda Violet , Katende Joseph Ssebwana , Baine Claire , Oluka Gerald Kevin , Odoch Geoffrey , Nantambi Hellen , Mugaba Susan , Namuyanja Angella , Ssali Ivan , Ejou Peter , Kato Laban ,   The COVID-19 Immunoprofiling Team, Musenero Monica , Kaleebu Pontiano
Published: February 2024

Introduction

This study sought to elucidate the long-term antibody responses to the Moderna mRNA-1273 COVID-19 vaccine within a Ugandan cohort, aiming to contribute to the sparse data on m-RNA vaccine immunogenicity in Sub-Saharan Africa.

Methods

We tracked the development and persistence of the elicited antibodies in 19 participants aged 18 to 67, who received two doses of the mRNA-1273 vaccine. A validated enzyme-linked immunosorbent assay (ELISA) was used to quantify SARS-CoV-2-specific IgG, IgM, and IgA antibodies against the spike (S) and nucleoproteins (N). The study’s temporal scope extended from the baseline to one year, capturing immediate and long-term immune responses. Statistical analyses were performed using the Wilcoxon test to evaluate changes in antibody levels across predetermined intervals with the Hochberg correction for multiple comparisons.

Results

Our results showed a significant initial rise in spike-directed IgG (S-IgG) and spike-directed IgA (S-IgA) levels, which remained elevated for the duration of the study. The S-IgG concentrations peaked 14 days afterboosting, while spike-directed IgM (S-IgM) levels were transient, aligning with their early response role. Notably, post-booster antibody concentrations did not significantly change. Prior S-IgG status influenced the post-priming S-IgA dynamics, with baseline S-IgG positive individuals maintaining higher S-IgA responses, a difference that did not reach statistical difference post-boost. Three instances of breakthrough infections: two among participants who exhibited baseline seropositivity for S-IgG, and one in a participant initially seronegative for S-IgG.

Discussion

In conclusion, the mRNA-1273 vaccine elicited robust and persistent S-IgG and S-IgA antibody responses, particularly after the first dose, indicating potential for long-term immunity. Prior viral exposure enhances post-vaccination S-IgA responses compared to naive individuals, which aligned with the prior-naïve, post-boost. The stable antibody levels observed post-booster dose, remaining high over an extended period, with no significant secondary rise, and no difference by baseline exposure, suggest that initial vaccination may sufficiently prime the immune system for prolonged protection in this population, allowing for potential to delay booster schedules as antibody responses remained high at the time of boosting. This finding calls for a reassessment of the booster dose scheduling in this demographic.