bluuebunny/crossref_metadata_2025 huggingface dataset:
Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors
Authors: Cooper Fay , Souilhol Celine , Haston Scott , Gray Shona , Boswell Katy , Gogolou Antigoni , Frith Thomas J. R. , Stavish Dylan , James Bethany M. , Bose Daniel , Kim Dale Jacqueline , Tsakiridis Anestis
Published: January 2024

The generation of the post-cranial embryonic body relies on the coordinated production of spinal cord neurectoderm and presomitic mesoderm cells from neuromesodermal progenitors (NMPs). This process is orchestrated by pro-neural and pro-mesodermal transcription factors that are co-expressed in NMPs together with Hox genes, which are essential for axial allocation of NMP derivatives. NMPs reside in a posterior growth region, which is marked by the expression of Wnt, FGF and Notch signalling components. Although the importance of Wnt and FGF in influencing the induction and differentiation of NMPs is well established, the precise role of Notch remains unclear. Here, we show that the Wnt/FGF-driven induction of NMPs from human embryonic stem cells (hESCs) relies on Notch signalling. Using hESC-derived NMPs and chick embryo grafting, we demonstrate that Notch directs a pro-mesodermal character at the expense of neural fate. We show that Notch also contributes to activation of HOX gene expression in human NMPs, partly in a non-cell-autonomous manner. Finally, we provide evidence that Notch exerts its effects via the establishment of a negative-feedback loop with FGF signalling.
Characterizing chromosomal instability-driven cancer evolution and cell fitness at a glance
Authors: Tijhuis Andréa E. , Foijer Floris
Published: January 2024

Chromosomal instability (CIN), an increased rate of chromosome segregation errors during mitosis, is a hallmark of cancer cells. CIN leads to karyotype differences between cells and thus large-scale heterogeneity among individual cancer cells; therefore, it plays an important role in cancer evolution. Studying CIN and its consequences is technically challenging, but various technologies have been developed to track karyotype dynamics during tumorigenesis, trace clonal lineages and link genomic changes to cancer phenotypes at single-cell resolution. These methods provide valuable insight not only into the role of CIN in cancer progression, but also into cancer cell fitness. In this Cell Science at a Glance article and the accompanying poster, we discuss the relationship between CIN, cancer cell fitness and evolution, and highlight techniques that can be used to study the relationship between these factors. To that end, we explore methods of assessing cancer cell fitness, particularly for chromosomally unstable cancer.
Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B
Authors: Peterson Ashley , Bennin David , Lasarev Michael , Chini Julia , Beebe David J. , Huttenlocher Anna
Published: January 2024

Neutrophil-directed motility is necessary for host defense, but its dysregulation can also cause collateral tissue damage. Actinopathies are monogenic disorders that affect the actin cytoskeleton and lead to immune dysregulation. Deficiency in ARPC1B, a component of the Arp2/3 complex, results in vascular neutrophilic inflammation; however, the mechanism remains unclear. Here, we generated human induced pluripotent stem cell (iPSC)-derived neutrophils (denoted iNeutrophils) that are deficient in ARPC1B and show impaired migration and a switch from forming pseudopodia to forming elongated filopodia. We show, using a blood vessel on a chip model, that primary human neutrophils have impaired movement across an endothelium deficient in APRC1B. We also show that the combined deficiency of ARPC1B in iNeutrophils and endothelium results in further reduction in neutrophil migration. Taken together, these results suggest that ARPC1B in endothelium is sufficient to drive neutrophil behavior. Furthermore, the findings provide support for using the iPSC system to understand human neutrophil biology and model disease in a genetically tractable system.
The Association Between Intraoperative Compromised Intestinal Integrity and Postoperative Complications in Cancer Patients
Authors: Hendriks Sharon , Huisman Monique G. , Stokmans Suzanne C. , Plas Matthijs , van der Wal-Huisman Hanneke , van Munster Barbara C. , Absalom Anthony R. , Nieuwenhuijs-Moeke Gertrude J. , de Bock Geertruida H. , van Leeuwen Barbara L. , de Haan Jacco J.
Published: January 2024

Background

Because of perioperative splanchnic hypoperfusion, the gut wall becomes more permeable for intraluminal microbes to enter the splanchnic circulation, possibly contributing to development of complications. Hypoperfusion-related injured enterocytes release intestinal fatty acid binding protein (I-FABP) into plasma, which is used as proxy of intestinal integrity. This study investigates the occurrence of intestinal integrity loss during oncologic surgery, measured by I-FABP change. Secondary the relationship between compromised intestinal integrity, and related variables and complications were studied.

Methods

Patients undergoing oncologic surgery from prospective cohort studies were included. Urine I-FABP samples were collected preoperatively (T0) and at wound closure (T1), and in a subgroup on Day 1 (D1) and Day 2 (D2) postoperatively. I-FABP dynamics were investigated and logistic regression analyses were performed to study the association between I-FABP levels and patient-related, surgical variables and complications.

Results

A total of 297 patients were included with median age of 70 years. Median I-FABP value increased from 80.0 pg/mL at T0 (interquartile range [IQR] 38.0–142.0) to 115 pg/mL at T1 (IQR 48.0–198.0) (p < 0.05). Age (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.02–1.08) and anesthesia time (OR 1.13, 95% CI 1.02–1.25) were related to stronger I-FABP increase. When comparing I-FABP change in patients experiencing any complications versus no complications, relative I-FABP change at T1 was 145% of T0 (IQR 86–260) versus 113% (IQR 44–184) respectively (p < 0.05).

Conclusions

A significant change in I-FABP levels was seen perioperatively indicating compromised intestinal integrity. Age and anesthesia time were related to higher I-FABP increase. In patients experiencing postoperative complications, a higher I-FABP increase was found.
La sostenibilidad del vídeo participativo como práctica comunitaria. El caso de InsightShare.
Authors: Moreno Domínguez José Manuel , Montero Sánchez David
Published: January 2024

La discusión académica en torno a la sostenibilidad en los medios de comunicación ha evolucionado mucho
recientemente, sobre todo en torno a los medios alternativos, comunitarios y del Tercer Sector. Frente al enfoque
economicista de los análisis de la sostenibilidad de los medios comerciales y de la evaluación de los medios
públicos en relación con la influencia del poder político, los medios comunitarios han movilizado una concepción de
la sostenibilidad que considera aspectos como la estructura organizativa, la diversidad de los equipos de trabajo o
el equilibrio medioambiental. El presente artículo se acerca al vídeo participativo como práctica comunitaria para
explorar los patrones de sostenibilidad que éste pone en juego. Se parte de una amplia revisión bibliográfica en torno
a la sostenibilidad en los medios comunitarios, así como de un análisis crítico de la literatura disponible en torno
al vídeo participativo. A nivel empírico, se examina el caso de estudio de InsightShare, una organización de origen
británico que constituye una referencia en la práctica del vídeo participativo. El texto concluye que la sostenibilidad
de InsightShare se articula en torno a la priorización de las relaciones comunitarias, tanto en lo que respecta al
funcionamiento de la propia organización como en relación con los proyectos en los que la misma participa. La
capacidad de InsightShare para desarrollar su misión en circunstancias distintas y el papel jugado en la articulación
de experiencias autónomas representan un ejemplo de buenas prácticas en lo que respecta a la concepción de la
sostenibilidad en sentido amplio.
Actitudes xenófobas en la juventud. Iniciativas desde la Responsabilidad Social Corporativa en los grupos de comunicación en el ámbito de la inclusión y diversidad cultural.
Authors: Sánchez Galán F. Javier
Published: January 2024

La juventud representa a un colectivo vulnerable y en continua crisis en las sociedades occidentales. Aunque es
posible describir actitudes intrínsecas a la condición juvenil (inestabilidad, incertidumbre, inconformismo…), otras
son fruto de la coerción que impone la posición en la estructura social que les ha tocado vivir. La juventud es, en
general, un colectivo tolerante con la diversidad cultural y la inmigración, pero una parte manifiesta comportamientos
xenófobos que es necesario analizar. En este trabajo se trata de identificar aquellos factores o variables que pueden
explicar este tipo de comportamientos. Por otra parte, nos encontramos ante un colectivo muy conectado a las
tecnologías de la comunicación e información, por lo que los grandes grupos de comunicación ofrecen una gran
influencia en la toma de decisiones y opiniones. Por este motivo es necesario que las empresas de comunicación
asuman la tarea de transmitir valores de tolerancia y respeto en una sociedad cada vez más diversa culturalmente.
Los hallazgos más relevantes has sido, por una parte, que la ideología política tiene un valor explicativo muy alto,
cuanto más se sitúan los jóvenes en el espectro izquierda-derecha hacia la derecha, más posibilidades existen de
manifestar comportamientos xenófobos. Por otra parte, la pobreza severa, también se presenta como un factor
explicativo con fuerza de los comportamientos xenófobos. Y, por último, que los grandes grupos de comunicación
cuyas memorias de sostenibilidad han sido analizadas no manifiestan una actitud clara en favor de la diversidad
cultural, ni en sus compromisos ni tampoco en sus acciones concretas.
Spanish Version of the Short Grit Scale (Grit-S): New evidence based on CFA and MIRT models in Peruvian University Students.
Authors: Yupanqui-Lorenzo Daniel E. , Becerra-Herrera Wilson A. , Diaz-Leon Ivan , Cardoza Sernaqué Manuel Antonio , Olivera-Carhuaz Edith S.
Published: January 2024

Studying grit's measurement helps to understand this psychological phenomenon associated with success. Grit-S structures of one-factor and two-factor have been reported in the literature, but there is a lack of reports based on Item Response Theory (IRT). Therefore, two objectives were proposed: to determine the factorial structure of the Spanish version of the Grit-S and explore the instrument through a Multidimentional Item Response Theory (MIRT) analysis. A nonprobabilistic sample of 899 subjects (41.0% female) was evaluated. The 8 items grit scale was used. The Confirmatory Factor Analysis (CFA) showed that the two-factor model obtained a good fit (CFI = 0.97, TLI = 0.95, RMSEA [90%CI] = 0.08 [0.07, 0.10]) unlike the one-dimensional model. An exploratory comparison analysis by MIRT also revealed that the two-factor model performed better (p < 0.001). Consequently, a confirmatory analysis determined an adequate fit of the two-factor model (C2 = 45.4; RMSEA [90%CI] = 0.05 [0.04 - 0.07]; TLI = 0.97; CFI = 0.99). Multidimensional discrimination values were within the expected range (> 1; > 1.5), although item 2 had low discrimination. Regarding difficulty, all items had a monotonic increase. The two-factor model fits the data by both CFA and MIRT. Both complementary analyzes demonstrate the potential of Grit-S to measure latent consistency and perseverance factors.
On The Runway
Authors: Fanning Paul
Published: January 2024

As the aerospace industry emerges from the turbulence of recent years’, Grégory Chauvet, General Manager of JPB Système, gives his thoughts on the challenges and opportunities that face manufacturers.
Putting Shingo into Practice
Authors: Merriman Chris
Published: January 2024

Who and what is Shingo?
Activity Card Sort’s existence and execute in various languages and versions: A scoping review
Authors:   Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand, Vetrayan Jayachandran , Chinchai Supaporn ,   Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand, Munkhetvit Peeraya ,   Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand, Suganthirababu Prathap ,   Saveetha College of Physiotherapy, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India, Dhippayom Jananya P. ,   Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai Province, Thailand
Published: January 2024

Background: Activity Card Sort (ACS) measures patient activity participation, especially in older adults. It was developed to evaluate instrumental, social, and leisure activities of low and high demand in various populations. Transferring an ACS tool between diverse settings is challenging due to significant socio-economic, linguistic, and environmental impacts. Hence, to tailor ACS tools to a specific society’s socio-cultural context, comprehension of the accessible validated ACS tools and their psychometric attributes is essential. Objective: This scoping review was conducted to explore the availability of the ACS tool and to summarize the psychometric properties, such as the reliability and validity, of different languages and versions of ACS available worldwide. Materials and methods: A search was performed in PubMed, PsycNET, Cochrane, and Embase. Two independent reviewers conducted the screening process and extracted the data. The total sample included 370 articles, of which 26 studies met the inclusion criteria, providing information on psychometric properties. English and non-English versions (Arabic, Dutch, and Spanish) in different populations were included. Results: Among the 26 studies in this review, most ACS studies used the English version (62.5%). All the reported studies revealed “good” internal consistency, in which the Cronbach’s alpha (α) ranges between 0.61 and 0.91. Test-retest reliability was measured using ICC values ranging from 0.78 to 0.98 for numeric data and Kappa statistics for binary data. Two studies used Kappa statistics to test the reliability, which ranged from 0.48 to 0.85 for all domains, indicating moderate to good reliability. Measures of content validation, face validity, concurrent, convergent, and discriminative validity were also reported. Conclusion: Good psychometric properties were reported. No study is available on the Indian population using the ACS tool. Hence, developing and validating an ACS tool for the Tamil Nadu population is needed.
Development and Stability Study of Oseltamivir Reconstitutable Dry Suspension from Capsules
Authors:   Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand, Pitaksuteepong Tasana , Kesornmalee Kitiya Kesornmalee ,   Mae Ramat Hospital, Mae Ramat District, Tak 63140, Thailand, Phanaphai Natthareephon ,   Samut Prakan Hospital, Samut Prakan District, Samut Prakan 10270, Thailand
Published: January 2024

Oseltamivir phosphate (OSEL) is recommended for the prevention and treatment of influenza virus infection. In a hospital pharmacy, OSEL liquid extemporaneous preparation is generally compounded on a case-by-case basis from the capsules because it can be stored for a certain period. Therefore, the objective of the current research was to develop an oseltamivir reconstitutable dry suspension (ORDS), and to evaluate the stability of the ORDS. The dry-suspending vehicles were first developed and subjected to stability tests. The stable vehicle was selected to mix with the content of OSEL capsules and dry powder was termed ORDS. The stability of ORDS was then tested in both dried and reconstituted states. It was found that the dry vehicle using xanthan gum as a suspending agent (at 0.25% w/v of the reconstituted suspension) was the most stable formulation at 25°C and 45°C under 75% relative humidity (RH) for 28 days. Upon mixing with OSEL capsule contents, ORDS in the dried state showed no change in either physical or chemical properties after storing at room temperature for 7 days. For the reconstituted state, the ORDS showed no change in odor and pH after storing at 2°C to 8°C in a refrigerator, and 25°C and 45°C under 75%RH for 14 days. However, its color was slightly darker after storing at 45°C. The percentage remaining OSEL at the refrigerator temperatures was 98.13% ± 1.63%, at 25°C was 100.30% ± 0.71% and at 45°C was 97.54% ± 1.38%. In conclusion, ORDS may be a convenient alternative to extemporaneous preparations. Keywords: Oseltamivir capsule, Reconstitutable dry suspension, Extemporaneous, Physico-chemical stability, Influenza
UBERIZAÇÃO DO TRABALHO: a percepção dos motoristas de transporte por aplicativos na cidade de Goiânia.
Authors: Moraes Rodrigo Bombonati de Souza
Published: January 2024

A uberização do trabalho evidencia uma nova forma de organizar, gerenciar e controlar o trabalho por meio das plataformas digitais. As ideias de autonomia, independência e empreendedorismo e precarização parecem subjazer a essa forma de gestão. Objetivou-se analisar a percepção dos motoristas de transporte por aplicativo quanto ao trabalho que realizam para as empresas-plataformas ou empresas-aplicativo na cidade de Goiânia, por meio de uma pesquisa descritiva com utilização do método Survey, envolvendo 99 motoristas. A análise utilizou a estatística descritiva e análise fatorial. Identificaram-se quantidades excessivas de dias e horas trabalhadas, além da constatação de que 78,7% dos motoristas ou possuem veículos financiados ou alugam um carro para poder trabalhar. Constituíram-se, ainda, seis componentes principais, assim rotulados: Formalização do emprego; Rendimentos; Autonomia; Perdas percebidas; Oportunidade de emprego; e Avaliação do trabalho. Os motoristas percebem benefícios na autonomia do trabalho flexível, além da necessidade de conter sua precarização.
GESTÃO DE RESÍDUOS SÓLIDOS URBANOS EM CONSÓRCIO PÚBLICO: o caso de Curitiba e região metropolitana
Authors: Lara Lucia Pereira , Grimm Isabel Jurema
Published: January 2024

A maioria dos municípios brasileiros ainda não implementaram de forma adequada a gestão dos Resíduos Sólidos Urbanos, na forma do que preconiza a Lei nº 12.305/201. Os consórcios intermunicipais podem colaborar na gestão minimizando custos financeiros ou mesmo técnicos, reduzindo os impactos ambientais negativos. Este artigo investiga a constituição do Consórcio Público Intermunicipal de Curitiba e Região Metropolitana, e os desafios da gestão dos Resíduos Sólidos Urbanos. A metodologia é de natureza qualitativa, descritiva com procedimento bibliográfico e documental. Entrevistou-se nove gestores municipais que integram o consórcio buscando compreender seu arranjo interinstitucional. Os resultados indicam que a constituição do consórcio pode se valer de práticas de governança para otimizar recursos financeiros, estabelecer um canal de comunicação para subsidiar as decisões na gestão consorciada, avaliar as políticas públicas e alinhá-las ao serviço de coleta e destinação final dos RSU, direcionando as ações, com mecanismos de gestão, controle e informação.
The Relationship Between Green Finance, Sustainable Technological Innovation and Energy Efficiency
Authors: Zhu Miaomiao
Published: January 2024

Sustainable technological innovation can promote this progress in finance. This optimization and upgrading of energy efficiency can provide a good energy environment for green development. The collaborative innovation of financial enterprises has brought such development to the tertiary industry, driving the upgrading of consumer demand, and thus promoting the development of green finance. At this same time, sustainable technological innovation will increase investment in environmental protection, reduce energy consumption, promote the reduction of carbon emissions in the financial industry, and accelerate the development of green finance. This paper uses the data envelopment analysis method to calculate the Marquis production efficiency index, examines the dynamic generation efficiency of intertemporal energy input and output, and calculates the energy efficiency of green finance. This article measures and deconstructs energy efficiency at the provincial level, and pays attention to its changes. The study depicted the efficiency distribution of 28 provinces in two stages of the survey period. By using random kernel estimation for two periods during the survey period, dynamic distribution three-dimensional maps and density contour maps of total factor energy productivity, energy utilization efficiency, and energy allocation efficiency growth rates were drawn for the two periods. The results show that the transfer probability group of energy efficiency and its decomposition terms mainly falls near the diagonal, indicating that TFP and its decomposition term growth rate have certain transferability. From 2005 to 2015, the energy utilization efficiency of the seven economic regions has been significantly improved, and the energy efficiency differences in different regions have gradually converged. The energy efficiency of the Yangtze River Delta and the Pearl River Delta is the highest and has been continuously improved, followed by the Beijing Delta, the central region, the northeast region and the southwest region are again in terms of energy efficiency. Compared with provinces with relatively poor industrial structures, provinces with better industrial structures do not have significant advantages in energy efficiency, while provinces with higher levels of technological innovation typically have relatively higher energy efficiency.
Intelligent Processing of Power Operation Data Based on Improved Apriori Algorithm
Authors: Zhao Xin , Huang Changda
Published: January 2024

This paper addresses several problems in the power system. Key challenges include low-power information integration, inappropriate system data management, inaccurate system data updating, and inefficient fault diagnosis. We focus on analyzing and diagnosing transmission line faults using the operation data of the power system. The study incorporates the quantitative identification of statements. This is done using the Apriori big data analysis and calculation method. Additionally, we utilize big data analysis and vast power operation data. We aim to achieve automatic analysis and pinpoint the causes of transmission line faults. Furthermore, we seek to optimize the traditional Apriori calculation method. This optimization results in a reduction of about 52% in the candidate item set calculation. The optimized M-Apriori calculation method can analyze the correlation between event index data and faults in real time, and realize automatic diagnosis and analysis of faults through operation data.
Low-Carbon Economic Dispatch of Integrated Energy Systems in Multi-Form Energy-intensive Parks Based on the ICT-GRU Prediction Model
Authors: Ning Liaoyi , Liang Kai , Zhang Bo , Gao Yang , Xu Zhilin
Published: January 2024

This paper presents a solution to the issues of redundancy and ambiguity in predicting variables associated with renewable energy output while aligning with the objectives of the “dual-carbon” energy strategy. A low-carbon economic dispatch method for multi-form energy-intensive parks is proposed, employing the ICT-GRU prediction model. Leveraging historical generation data, the ICT-GRU model enables accurate forecasting of renewable energy output. Subsequently, a comprehensive energy system model is developed considering the carbon emission characteristics and control features of park entities. The model aims to minimize operational costs and facilitate low-carbon economic dispatch. The effectiveness of the proposed method is demonstrated through a case study conducted in a multi-form energy-intensive load park integrated into a power grid. The results validate its capability to achieve low-carbon economic operation and provide valuable insights for grid dispatch optimization.
Analysis of the Factors Affecting the Logistics Efficiency of Urban Farm Products in the Context of Low-carbon Economy
Authors: Wang Xiaolu , Ni Danyue
Published: January 2024

The refrigeration equipment used to preserve the freshness of farm products in the farm logistics process generates carbon emissions, so the factors affecting the logistics efficiency need to be analyzed to make it sustainable in the context of low-carbon economy. This paper briefly introduced the calculation method of farm product logistics efficiency in the context of low-carbon economy and analyzed the farm product logistics industry in Jiangsu Province from 2011 to 2020. The results suggested that the input-output efficiency of the farm product logistics industry in Jiangsu was relatively high at the level of logistics technology in the context of low-carbon economy, but there was still room for improvement in the expansion scale; the economic level, industrial agglomeration, and industrial structure had a significant positive effect on the efficiency of farm product logistics, and the environmental constraints had a significant inhibitory effect on the efficiency of farm product logistics. Finally, several suggestions were put forward according to the analysis results.
Prediction and Management of Building Energy Consumption Based on Building Environment Simulation Design Platform DeST and Meteorological Data Analysis Algorithm
Authors: Bai Chaoqin , Liu Junrui
Published: January 2024

Currently, the carbon emissions of building energy consumption account for a significant portion of all carbon emissions. How to reduce carbon emissions to achieve carbon neutrality is an important current research direction. Therefore this research builds a predictive algorithm model for analyzing energy consumption data of meteorological buildings using DeST platform for energy saving and emission reduction to achieve carbon neutrality. The new model uses Internet of Things and cloud platform technology to build a simulation building platform, and uses the support vector machine algorithm in the analysis algorithm to vectorize building energy consumption data, which can achieve normalization processing of building energy consumption and meteorological data. By processing building energy consumption data, prediction of building energy consumption at the next moment can be achieved. The experimental results show that the precision and accuracy of the new algorithm are higher than genetic algorithm 1 and 0.15 respectively, and 0.6 and 0.07 higher than clustering analysis algorithm respectively. Therefore, applying this algorithm model to building energy consumption prediction can significantly improve the accuracy and precision of the algorithm.
Soil Moisture Prediction Model Based on Improved GRU Recurrent Neural Network
Authors: Wang Guowei , Wei Chunying , Yan Li , Li Jian
Published: January 2024

Soil moisture plays a crucial role in land water and energy cycles, and has a certain impact on weather and climate change. In agricultural production, crop moisture status can be determined based on soil moisture, and timely and effective irrigation strategies can be formulated to ensure grain yield while saving water resources, maximizing the value of agricultural water resource utilization, and achieving sustainable development. Therefore, the accuracy of soil moisture prediction has important research value for many fields such as agriculture and climate. In this paper, the super parameters of GRU Recurrent neural network are optimized by intelligent seagull optimization algorithm using a small number of influencing factors, namely, atmospheric temperature, atmospheric humidity, rainfall and soil moisture data, and a soil moisture prediction model is established. The model was used to predict soil moisture for the next 12 hours, 24 hours, 36 hours, and 48 hours, respectively. The final experiment showed that the model in this paper had better predictive effect on soil moisture, with the best predictive evaluation index data being MAPE (12h) = 4.4120%, R2 (12h) = 0.94605, and RMSE (12h) = 1.9998; By comparing the prediction results of multiple time steps vertically, it was found that the prediction accuracy of the model in this paper decreased more smoothly, meeting the requirements of soil moisture prediction.
José Saramago: do Iberismo ao Transiberismo
Authors: Reis Carlos
Published: January 2024

Neste artigo procede-se a um confronto de posições acerca do iberismo, partindo-se de Miguel Torga e dos seus Poemas Ibéricos (1965). O ponto de chegada deste trajeto é o romance A Jangada de Pedra (1986), de José Saramago. Transita-se, assim, da noção de iberismo para o conceito de transiberismo, no quadro de uma abordagem assumidamente parcelar; tal abordagem tem em conta transformações históricas e políticas que, no final do século xx, vão além do cenário vivido por Torga. Emerge, então, em José Saramago, uma progressiva preocupação com o iberismo, traduzida em diversos textos ensaísticos que se sucedem ao romance A Jangada de Pedra, como que explicitando e aprofundando os grandes sentidos que nele são representados. Assim, tal como foi sendo elaborado por Sarama- go, o projeto transiberista reporta-se a uma realidade geoestratégica a vir, motivada por aquilo a que o romancista chamou a «vocação do Sul» das nações ibéricas.
Glaucoma detection model by exploiting multi-region and multi-scan-pattern OCT images with dynamical region score
Authors: Liu Kai , Zhang Jicong
Published: January 2024

Currently, deep learning-based methods have achieved success in glaucoma detection. However, most models focus on OCT images captured by a single scan pattern within a given region, holding the high risk of the omission of valuable features in the remaining regions or scan patterns. Therefore, we proposed a multi-region and multi-scan-pattern fusion model to address this issue. Our proposed model exploits comprehensive OCT images from three fundus anatomical regions (macular, middle, and optic nerve head regions) being captured by four scan patterns (radial, volume, single-line, and circular scan patterns). Moreover, to enhance the efficacy of integrating features across various scan patterns within a region and multiple regional features, we employed an attention multi-scan fusion module and an attention multi-region fusion module that auto-assign contribution to distinct scan-pattern features and region features adapting to characters of different samples, respectively. To alleviate the absence of available datasets, we have collected a specific dataset (MRMSG-OCT) comprising OCT images captured by four scan patterns from three regions. The experimental results and visualized feature maps both demonstrate that our proposed model achieves superior performance against the single scan-pattern models and single region-based models. Moreover, compared with the average fusion strategy, our proposed fusion modules yield superior performance, particularly reversing the performance degradation observed in some models relying on fixed weights, validating the efficacy of the proposed dynamic region scores adapted to different samples. Moreover, the derived region contribution scores enhance the interpretability of the model and offer an overview of the model’s decision-making process, assisting ophthalmologists in prioritizing regions with heightened scores and increasing efficiency in clinical practice.
Holographic imaging of antiferromagnetic domains with in-situ magnetic field
Authors: Harrison Jack , Jani Hariom , Hu Junxiong , Lal Manohar , Lin Jheng-Cyuan , Popescu Horia , Brown Jason , Jaouen Nicolas , Ariando A. , Radaelli Paolo G.
Published: January 2024

Lensless coherent x-ray imaging techniques have great potential for high-resolution imaging of magnetic systems with a variety of in-situ perturbations. Despite many investigations of ferromagnets, extending these techniques to the study of other magnetic materials, primarily antiferromagnets, is lacking. Here, we demonstrate the first (to our knowledge) study of an antiferromagnet using holographic imaging through the ‘holography with extended reference by autocorrelation linear differential operation’ technique. Energy-dependent contrast with both linearly and circularly polarized x-rays are demonstrated. Antiferromagnetic domains and topological textures are studied in the presence of applied magnetic fields, demonstrating quasi-cyclic domain reconfiguration up to 500 mT.
Photon-level single-pixel 3D tomography with masked attention network
Authors: Song Kai , Bian Yaoxing , Zeng Fanjin , Liu Zhe , Han Shuangping , Li Jiamin , Tian Jiazhao , Li Kangze , Shi Xiaoyu , Xiao Liantuan
Published: January 2024

Tomography plays an important role in characterizing the three-dimensional structure of samples within specialized scenarios. In the paper, a masked attention network is presented to eliminate interference from different layers of the sample, substantially enhancing the resolution for photon-level single-pixel tomographic imaging. The simulation and experimental results have demonstrated that the axial resolution and lateral resolution of the imaging system can be improved by about 3 and 2 times respectively, with a sampling rate of 3.0 %. The scheme is expected to be seamlessly integrated into various tomography systems, which is conducive to promoting the tomographic imaging for biology, medicine, and materials science.
Modeling and optimization strategies for dye-doped super twisted nematic liquid crystal light valves
Authors: Hou Chien-Tsung , Lin Tsung-Hsien , Mi Xiang-Dong , He Mingqian , Chien Liang-Chy
Published: January 2024

This study provides a comprehensive investigation of dye-doped super twisted nematic liquid crystal (DDSTNLC) with the aim of uncovering its potential applications. Using design of experiments (DoE) techniques, we elucidated the relationships between physical variables and constructed a transmission model. We then used Monte Carlo simulations to demonstrate the potential applications of DDSTNLC in various optical performances, including high light transmittance and contrast ratio. The investigation combining the modeling and DoE paves the way for advancing progress in the development of DDSTNLC-based light valves.
Tiroides endotorácico. Indicaciones del abordaje endotorácico
Authors: Jiménez-López Marcelo F. , Gómez-Hernández María Teresa
Published: January 2024

Introducción y objetivo: La incidencia de bocio endotorácico entre los pacientes sometidos a tiroidectomía oscila entre el 6% y el 30%. Aunque el abordaje cervical es suficiente en la mayoría de los casos, el abordaje endotorácico puede ser necesario en el 1-5.5% de los pacientes. Por lo que es recomendable anticiparlo. El objetivo del presente artículo es describir los factores predictivos de necesidad de este tipo de abordaje. Síntesis: Los principales factores de riesgo para la realización de esternotomía en los casos de bocio subesternal son la extensión por debajo del cayado aórtico y la localización retrotraqueal o retrovascular. El abordaje torácico será igualmente necesario en bocios ectópicos mediastínicos sin conexión con el tiroides cervical y se recomendará la valoración por un cirujano torácico en casos de bocio olvidado, así como en pacientes con antecedentes de radioterapia o cirugía cervical y sospecha de malignidad con afectación extra-tiroidea. La elección del abordaje dependerá de la localización, del tamaño de la masa y su relación con los órganos vecinos; los abordajes mínimamente invasivos pueden ser alternativas seguras a la esternotomía o la toracotomía. Las complicaciones postoperatorias más frecuentes de la resección de tiroides endotorácico son típicas de la cirugía tiroidea: parálisis recurrencial temporal o permanente, hipoparatiroidismo, insuficiencia respiratoria y sangrado postoperatorio. Conclusiones: Hasta en un 5% de las tiroidectomías, puede ser necesario un abordaje torácico, por lo que es conveniente anticiparlo. El abordaje torácico será necesario en casos de bocio con extensión por debajo del cayado, localización retrotraqueal o retrovascular y en bocios mediastínicos sin conexión con el tiroides cervical.
Anotaciones para estructurar una revisión sistemática
Authors: Pardal-Refoyo José Luis , Pardal-Peláez Beatriz
Published: January 2024

Introducción y objetivo: El artículo de revisión ofrece al investigador y al lector información clarificadora sobre un tema concreto. La revisión bibliográfica sistemática debe estar especificada de tal forma que ha de poder ser reproducida por cualquier investigador. Objetivo: orientar a los autores de un trabajo de investigación de revisión sistemática con o sin metanálisis, en algunos aspectos organizativos prácticos. Método: Revisión narrativa. Resultados y discusión: Se revisan siete pasos para organizar el trabajo de revisión: 1- Preparar los recursos informáticos, 2- diseñar la pregunta PICO, 3- elegir las variables que se estudiarán, 4- diseñar y hacer la búsqueda bibliográfica, 5- seleccionar inicialmente los artículos, 6-selección final de artículos y 7- redactar el informe de investigación.
Proceso linfoproliferativo tipo T en lengua: a propósito de un caso
Authors: Almeida-Ayerve Cristina Nicole , Fernández-Nava María José , Marcos-Alonso Susana , Ferreira-Cendón Sofía , Coronel-Touma Guillermo Salib , Blanco-Perez Pedro
Published: January 2024

Introducción: Los síndromes linfoproliferativos (SLP) de estipe T, constituyen el 15% de todos los linfomas No Hodking. La localización de los linfomas extra nodales más frecuentes se encuentra en el área gastrointestinal, seguida del área cérvico-facial (34%). En la cavidad oral se localizan por lo general en el anillo de Waldeyer (5-10%), siendo los linfomas de lengua los más infrecuentes, representando el 3% de todos los linfomas del área cérvico-facial. Dentro de las formas cutáneas, la enfermedad linfoproliferativa CD30+, constituye el segundo tipo más frecuente de linfoma cutáneo tipo T.

Descripción del caso clínico: Paciente mujer de 78 años derivada de atención primaria por persistencia de lesión en el dorso de hemilengua derecha además de glosodinia y odinofagia. En la exploración física se describió lesión nodular en medallón grisácea que no sobrepasaba la línea media, indurada y dolorosa a la palpación. Bajo anestesia local, se realizó una toma de biopsia, la misma que describió proceso linfoproliferativo T-CD30+ y con resultado del ADN de la muestra enviada a biología molecular con presencia de reordenamiento clonal del receptor de células T. Con estos resultados, se solicitó prueba de imagen (PET-TAC) de cuerpo entero donde no se evidenciaron focos sugerentes de infiltración linfoproliferativa metabólicamente activa. Con estos resultados se derivó a la paciente al servicio de Hematología para su valoración y posterior tratamiento pertinente.

Conclusiones: Los linfomas de localización extranodal en lengua al ser muy infrecuentes representan un reto diagnóstico, por lo que es importante tenerlos en cuenta a la hora de su valoración además de una adecuada correlación clínico-patológica apoyados siempre en los exámenes complementarios de imagen y por supuesto histológicos y de biología molecular.
Rinofototerapia como tratamiento adyuvante en la rinitis alérgica. Revisión de la literatura
Authors: Sánchez-Lozano Jesús , Martínez-Pizarro Sandra
Published: January 2024

Introducción y objetivo:
La rinitis alérgica es una enfermedad inflamatoria crónica de la mucosa nasal, mediada por inmunoglobulina E. Afecta a uno de cada seis individuos, con una prevalencia del 10% al 40 % en la población. En los últimos años se ha propuesto el uso de la rinofototerapia para reducir sus síntomas en pacientes que no pueden beneficiarse de los corticosteroides intranasales o los antihistamínicos orales; así como tratamiento adyuvante a los mismos. El objetivo de esta revisión es analizar la eficacia de la rinofototerapia como tratamiento adyuvante en la rinitis alérgica.

Método:
Se realizó una revisión siguiendo las directrices PRISMA. Se consultaron las bases de datos de PubMed, Cinahl, PsycINFO, SPORTDiscus, Academic Search Complete, Lilacs, IBECS, CENTRAL, SciELO, y WOS. Se utilizó la herramienta Cochrane para valorar el riesgo de sesgo y la calidad de la evidencia se evaluó GRADE.

Resultados:
La rinofototerapia es un tratamiento adyuvante eficaz en la rinitis alérgica. La muestra total fue de 251 pacientes. En todos los estudios fue segura la aplicación de rinofototerapia y la duración del tratamiento osciló entre dos y seis semanas, con una media de tres veces por semana.

Discusión:
En el futuro sería necesario continuar investigando para establecer un protocolo unificado en cuanto a la frecuencia, duración y número de sesiones. Así como analizar el posible efecto sinérgico de este tratamiento con otras terapias.

Conclusiones:
La rinofototerapia fue eficaz en pacientes con rinitis alérgica. Esta terapia mejora los síntomas clínicos de estornudos, rinorrea, obstrucción nasal, prurito nasal, prurito de paladar, las mediciones del flujo máximo inspiratorio nasal, la calidad de vida del paciente y la severidad de los síntomas.
Irányítás mint hajózás – a „governance” értelméről
Authors: Lan Li Bai
Published: January 2024

„A végtelen sajátosságának tűnik, hogy mindenhol és mindenben jelen legyen.” (Aquinói Szt. Tamás: Summa Theologiae)
Az európai védelmi rendszer jelene és jövője – dilemmák, kritikák, lehetőségek
Authors: Józsa Tamás
Published: January 2024

Kevés esemény tartja jobban ébren az aktív hírolvasók figyelmét 2023-ban, mint az orosz-ukrán háború, amely most már több mint másfél éve dúl Európa keleti részén. Olyan jelenetek tanúi vagyunk, amelyektől a békében és többnyire jólétben élő európai néplélek már elszokott. A zord valóság azonban itt is felütötte fejét és ez hirtelen reakcióra kényszerítette a kontinens országait. A politikai vezetők prioritási listáinak élére került a háborúhoz való hozzáállás, és az ukrán védelem támogatásának kérdésköre. Jelenlegi tudásunk szerint nehezen képzelhető el gyors békekötés, amely még inkább arra sarkallja az érintett országokat, hogy erősebb álláspontot foglaljanak és cselekedjenek. Augusztus második felében például Dánia és Hollandia bejelentette, hogy F-16-os vadászgépeket küld Ukrajnába (Sabbagh, 2023), egy hónapra rá pedig Lengyelország úgy tűnik, konfliktusba került szomszédjával (Radford & Easton, 2023). A fegyverkezési terep dinamikusan változik, vannak, akik a konfliktus eszkalálódásától tartanak. Ráadásul, ehhez az eleve összetett képlethez hozzáadódnak olyan külső politikai tényezők is, mint például a 2024-es amerikai elnökválasztás eredménye, amely döntően befolyásolhatja a háború kimenetét, vagy legalábbis Európa szerepét. Mindezen események fényében kívánok hasznos és átfogó képet nyújtani az európai védelmi rendszer helyzetéről, annak kritikáiról és esetleges lehetőségeiről.
Growth and productive sophistication of Minas Artisanal Cheese from Canastra: an analysis based on innovative processes in natural resources
Authors: Bastos Letícia Silva , Consoni Flávia Luciane , Mesquita Fernando Campos
Published: January 2024

This article aims to delineate the role of innovation in the successful outcomes of Minas Artisanal Cheese (QMA) from Canastra. The methodological foundation is built upon literature review, documentary analysis, field research, and interviews. Our findings reveal the interplay between traditional and scientific knowledge as a pivotal element in the productive sophistication of Canastra’s QMA, facilitating work enhancement and striving to meet consumer market demands while maintaining local know-how and practices, which the society-nature relationship has historically shaped. The discussion is situated within the realm of empirical studies on natural resource-based innovation in Latin America and reflections on Territorial Innovation Systems (TIS), which consider a multiscale perspective of the innovation process prevalent in studies in the field of Knowledge and Innovation Geography. Despite advancements, we underscore that the establishment of Canastra’s QMA still faces challenges stemming from typical structural frailties of peripheral TIS. We aspire that these results not only contribute to comprehending the productive region of Canastra’s QMA but also serve as a supportive framework for innovation policies that acknowledge the necessity of contextual considerations in regional realities.
Afterimages of the 20th century’s first half: Polish lawyers confronting the shadows of history
Authors: Lipiec Stanisław
Published: January 2024

W perspektywie socjologii prawa przeanalizowano, w jaki sposób wydarzenia historyczne pierwszej połowy XX wieku wpłynęły na kształt współczesnej praktyki prawniczej. Posługując się jakościowymi wywiadami pogłębionymi, zebrano spostrzeżenia doświadczonych polskich prawników, wielu praktykujących jeszcze w okresie Polskiej Rzeczpospolitej Ludowej czy w czasach transformacji lat 90. Ich świadectwa nie tylko rzucają światło na ewolucję sposobu pracy prawników, ale także podkreślają skomplikowaną relację między strukturami społecznymi a stosowaniem prawa dzisiaj i w przeszłości. Badanie ujawnia nierozerwalny związek między dawnymi warunkami społeczno-politycznymi a dzisiejszymi polskimi ramami prawnymi, etyką i praktyką prawników, podkreślając konieczność integrowania perspektywy socjologii prawa w nowoczesnej praktyce prawniczej.
„Pojedynek amerykański” w Kodeksie karnym Makarewicza
Authors: Janikowski Jarosław
Published: January 2024

W artykule przedstawiono zagadnienie „pojedynku amerykańskiego”, który polega na zawarciu porozumienia dwóch osób co do uzależnienia samobójstwa jednego z nich od ściśle określonych warunków lub okoliczności losowych. Najczęściej objawiał się w postaci losowania kul, gdzie wyciągający kule czarną miał popełnić samobójstwo. Przed wejściem w życie Kodeksu karnego z 1932 r. karalność pojedynku amerykańskiego znały kodeks karny węgierski oraz kodeks karny rosyjski. Mimo że wielu przedstawicieli doktryny uznawało „pojedynek amerykański” za pośrednie podżeganie do samobójstwa, to Kodeks karny z 1932 r. tworzył odrębny czyn zabroniony mocą przepisu art. 229. Istocie „pojedynku amerykańskiego”, w odróżnieniu od pojedynku w jego klasycznej formie, nie poświęcono zbyt wiele uwagi. Warto zaznaczyć, że określenie „pojedynek amerykański” jest podwójnie błędne, gdyż brak w nim zwykłych cech pojedynku, a jego etiologia nie wskazuje na pochodzenie amerykańskie.
TÜRKİYE’DE SOSYAL GİRİŞİMCİLİK VE GELİŞİM SÜRECİ
Authors: AKTAŞ Ülkü Neslihan , AKDEVE Erdal
Published: January 2024

Bu araştırmanın temel amacı Türkiye’de sosyal girişimciliğin mevzuat ve politikalar çerçevesinde gelişimini incelemek ve mevzuatın sosyal girişimcilik üzerindeki etkilerini değerlendirmektir. Türkiye’deki sosyal girişimcilik faaliyetlerinin mevcut durumu ve tarihsel gelişiminin incelenmesi amacıyla durum çalışması yöntemi kullanılmış ve doküman analizi yapılmıştır. Doküman analizi aşamasında Mevzuat Bilgi Sisteminin yanı sıra Kalkınma Planları ve Cumhurbaşkanlığı Yıllık Programları ile kooperatif, vakıf ve derneklere ilişkin mevzuat detaylı bir şekilde incelenmiştir. Araştırma sonucunda son 10 yıl içinde politika belgelerine dahil edilen sosyal girişimciliğin somut yasal mevzuata dayandırılamaması sebebiyle üst politika belgelerindeki yerini kaybetmeye başladığı tespit edilmiştir. Bu araştırma öncelikle Türkiye’de sosyal girişimciliğin mevzuat ve politika kapsamında gelişimine yönelik bütünsel bir çerçeve ortaya koymaktadır. Buna ek olarak araştırma kapsamında öne sürülen kar amacı gütmeyen şirketlere yönelik detaylar sosyal girişimciliğin gelişimine somut bir öneri sunmaktadır.