bluuebunny/crossref_metadata_2025 huggingface dataset:
Lipoprotein-associated Phospholipase A2 in Coronary Artery Disease
Authors: Dimitroglou Yannis , Sakalidis Athanasios , Mavroudis Andreas , Kalantzis Charalambos , Valatsou Angeliki , Andrikou Ioannis , Christofi Angela , Mantzouranis Emmanouil , Kachrimanidis Ioannis , Bei Evellina , Lazarou Emilia , Tsioufis Costas , Tousoulis Dimitris , Lazaros George
Published: October 2022

Coronary artery disease (CAD) is the leading cause of morbidity and mortality in western societies. Therefore the identification of novel biomarkers to be used as diagnostic or therapeutic targets is of significant scientific interest. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is one such protein shown to be involved in endothelial dysfunction, vascular inflammation and ather-ogenesis. Several epidemiological studies have associated high Lp-PLA2 activity with an increased risk for CAD even when other CAD risk factors or inflammation markers were included in the mul-tivariate analysis. These findings were strengthened by the results of relevant meta-analyses. How-ever, randomized trials failed to establish Lp-PLA2 as a therapeutic target. Specifically, pharmaceu-tical inhibition of Lp-PLA2 when compared to the placebo failed to demonstrate a significant asso-ciation with improved prognosis of patients with stable CAD or after an acute coronary syndrome (ACS). This review focuses on the available data that have investigated the potential role of Lp-PLA2 as a biomarker for CAD.
Anticancer Tetrahydrocarbazoles: A Wide Journey from 2000 Till Date
Authors: Kumar Nitin , Gupta Pankaj
Published: October 2022

Tetrahydrocarbazoles (THCz) are widespread in numerous indole alkaloids and have been
reported since time for exhibiting profound pharmacological potential. Many pharmaceuticals drugs have
tetrahydrocarbazole nucleus in their structure e.g. vinca alkaloids (Vincristine, Vinblastine, Vinorelbine),
Frovatriptan, (R)-Ramatroban, Ondansetron, etc. that are used in various multifactorial diseases. In this
review article, the anticancer potential of tetrahydrocarbazole based derivatives has been covered, enumerating
their vast journey from the year 2000 to 2021. Since the last twenty-one years, tetrahydrocarbazoles
have been a matter of focus among researchers worldwide, whereby several novel tetrahydrocarbazole
derivatives have been synthesized and reported for their anticancer potential against various cancer
cell lines. Tetrahydrocarabzole and its derivatives have exhibited profound anticancer potential mediated
via various cancer pathways like apoptosis, cell cycle arrest, microtubule inhibition, Nrf2 Modulators,
DNA intercalators, pERK and pRb phosphorylation, VEGF (Vascular Endothelial Growth Factor) and
TNF-α inhibition, TPSO (translocator protein), Histone Deacetylase (HDAC) Inhibitors also discussed.
The present review entails the synthesis, SAR studies, and anticancer mechanism of tetrahydrocarbazoles
derivatives reported in review literature till date, and would provide a strong database to the medicinal
chemist world over in discovering newer potential anticancer agent against various types of cancer diseases.
Rational Drug Design and In vitro Cell Line Studies of Some N-(4-(1Hbenzo[
d]imidazol-2-yl)phenyl)arylamine Derivatives as Aromatase Inhibitors
for the Treatment of Cancer
Authors: Sabale Prafulla M. , Sayyad Nusrat B.
Published: October 2022

Background:

Aromatase is a catalytic enzyme involved in the biosynthesis of estrogen from androgen. It catalyzes the last rate-limiting/crucial critical step in estrogen biosynthesis. Following the success of the aromatase inhibitor, researchers are working on developing a small physiologically active molecule with fewer side effects and improved tolerance.

Objectives:

Inhibition of the aromatase enzyme, which plays a major role in the rate-limiting phase, is one strategy to prevent estrogen synthesis. After knowing the importance of nitrogen atom containing moieties in the treatment of breast cancer, we have designed some N-(4-(1H-benzo[d]imidazol-2-yl)phenyl)arylamine derivatives through in silico screening such as ADMET analysis and molecular docking studies. From the present investigation we aimed for the synthesis and biological evaluation of the most potent derivatives obtained in this study.

Methods:

The selected derivatives were synthesized and confirmed by spectral analysis (FTIR, 1H NMR, and Mass). Cytotoxic activity of the compounds was evaluated by colorimetric MTT assay on MDA-MB-231 (breast adenocarcinoma), MCF-7(breast adenocarcinoma), A549 (lung adenocarcinoma) NCI-H23 (Lung carcinoma) and A-498 (Renal carcinoma) cell line using Doxorubicin hydrochloride as positive control.

Results:

From present investigation, we have concluded that compound 10 [N-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-1H-benzo[d]imidazol-5-amine) is most potent and exhibited -9.5 kcal/mol binding affinity. It has formed conventional hydrogen bonds with ALA306 and THR310. It displayed most promising activity with GI50 value 0.796±0.06 µM, 0.695±0.05 µM, 1.14±0.06 µM, 2.15±0.04 µM, and 0.987±0.07 µM against MDAMB-231, MCF-7, A-549, NCI-H23, and A-498, respectively when compared with Doxorubicin (0.306±0.04 µM, 0.270±0.02 µM, 0.297±0.04 µM, 0.305±0.04 µM, and 0.345±0.09 µM).

Conclusion:

From present investigation it is concluded that the designed molecules had potential to be developed as broad spectrum anticancer agents.
Gefitinib: An Updated Review of its Role in the Cancer Management, its
Nanotechnological Interventions, Recent Patents and Clinical Trials
Authors: Kumar Pankaj , Mangla Bharti , Javed Shamama , Ahsan Waquar , Musyuni Pankaj , Ahsan Aarif , Aggarwal Geeta
Published: October 2022

Background:

Gefitinib, a tyrosine kinase inhibitor, is effectively used in the targeted
treatment of malignant conditions. It suppresses the signal transduction cascades leading to cell
proliferation in the tumors and is now currently approved in several countries globally as secondline and third-line treatment for non-small cell lung cancer (NSCLC).

Objective:

This review is aimed to summarize the journey of gefitinib as an established anticancer
drug for the management of various cancers. Moreover, this review will focus on the mechanism
of action, established anticancer activities, combination therapy, nanoformulations, as well as recent clinical trials and patents on gefitinib

Methods:

The data for this review was collected from scientific databases such as PubMed, Science Direct, Google Scholar, etc. Recent patents on gefitinib granted in the last two years were
collected from databases Patentscope, USPTO, Espacenet, InPASS and Google Patents. Data for
the recent clinical trials were obtained from the U.S. National Library of Medicine database.

Results:

Recent pre-clinical and clinical studies during the period 2015-2021 demonstrating the
efficacy of gefitinib were selected and summarized. Total 31 patents were granted in the year
2020-2021 concerning gefitinib. The efficacy of gefitinib against lung cancer, as well as other
cancer types, including breast, prostate, colon, cervix etc., was reviewed.

Conclusion:

Gefitinib showed significant advantages in being more effective, safer and more stable, and the associated biopharmaceutical problems are addressed by the application of nanotechnology. The combination therapy using gefitinib and various anticancer molecules of natural and
synthetic origin has shown an improved anticancer profile.
Potential Action of Lactobacillus Probiotics Against Fungi of the
Genus Candida: A Bibliographic Review
Authors: Pimentel Milton Marcus Neves Sousa Carneiro , de Carvalho Alves Janaína , Pinheiro Lúcio Henrique Sousa , Roselino Mariana Nougalli
Published: October 2022

Background:

The use of Lactobacillus probiotics may confer beneficial effects
on an individual’s health, such as the ability to act against fungi of the genus Candida.
There are about 200 species of those yeasts, and they can develop candidiasis infections,
which affect about 75% of adult women.

Objective:

This study aimed to raise articles that investigated the potential action of several
Lactobacillus strains in front of Candida species.

Method:

For this review, 15 articles published between 2015 and 2020 were studied.

Results:

The results showed the Lactobacillus species L. paracasei, L. acidophilus, L. helveticus,
L. rhamnosus, L. reuteri, and L. gasseri have the potential action to inhibit the
growth and quantity of colony-forming units of Candida species in vitro studies. Further,
they can reduce the rate of candidiasis recurrence and increase the cure rate, mainly when
associated with traditional pharmacotherapy, as observed in vivo studies.

Conclusion:

The time of use and the strain of Lactobacillus probiotics can also be determining
factors for the efficiency in the treatment against Candida species, suggesting that a
long time of use of Lactobacillus probiotics is directly associated with a better result.
A Brief Review of Radioactive Materials for Therapeutic and Diagnostic Purposes
Authors: Alam Md. Aftab , Bharti Manisha , Rao Gudhanti Siva Nago Koteswara , Sharma Pramod Kumar
Published: October 2022

Radiation treatment has been advancing ever since the discovery of X-rays in 1895.The goal of radiotherapy is to shape the best isodose on the tumor volume while preserving normal tissues. There are three advantages: patient cure, organ preservation, and cost-effectiveness. Randomized trials in many various forms of cancer (including breast, prostate, and rectum) with a high degree of scientific proof confirmed radiotherapy's effectiveness and tolerance. Such accomplishments, which are critical to patients' quality of life, have been supported in the past. Radiopharmaceuticals were developed for the diagnosis and therapy of a variety of disorders, hyperthyroidism, bone discomfort, cancer of the thyroid gland, and other conditions like metastases, renal failure, and myocardial infarction and cerebral perfusion. It is also possible to sterilize thermo-labile materials with the radioactive substance. This includes surgical dressings and a wide range of other medical supplies. Nuclear medicine provides various advantages, including tumor localization, safe diagnosis, no radiation buildup, and excellent treatment effectiveness. Nowadays, the field of nuclear pharmacy is focused on developing novel radioactive pharmaceutical substances that will be useful.
Solid Lipid Nanoparticles (SLNs): Advancements in Modification
Strategies Toward Drug Delivery Vehicle
Authors: Al-Sayadi Galal Mohsen Hussein , Verma Abhishek , Choudhary Yash , Sandal Pallavi , Patel Preeti , Singh Dilpreet , Gupta Ghanshyam Das , Kurmi Balak Das
Published: October 2022

Solid lipid nanoparticles are at the cornerstone of the swiftly growing area of medical
nanotechnology, having several potential functions in drug delivery, research, clinical care, and a
variety of other fields. They provide the opportunity of developing novel therapies due to their
unique properties, such as small particle size and being prepared from physiological biodegradable
lipids. The loading of bioactive molecules into nanocarriers is a novel drug delivery prototype
employed for various drug targeting levels. Hence, SLNs hold a great promise for achieving the
aim of targeted and controlled drug delivery. For this reason, they have attracted the extensive
attention of scientists and researchers. This review is based on recent studies and research, and
here we present advantages, disadvantages, and preparation methods, several advanced
modifications, targeting strategies, and recent applications of solid lipid nanocarriers in drug
delivery systems.
Patient Monitoring System using Blockchain and IoT Technology
Authors: Shukla Meenu , Sethi Deepak , Bindal Loveneesh , Mani Kushal , Upadhyay Kunal , Sharma Mitul
Published: October 2022

Background:

Recently, the construction of a smart city has accelerated due to developing technologies such as 5G and the Internet of things (IoT). The IoT is gaining access day by day in the area of the remote monitoring system. Along with smart city concepts, intelligent patient monitoring systems and intelligent health are being developed. Combining the two, here, patients have a nurse navigation system and a doctor emergency call system. IoT improves the effectiveness of medical equipment by providing real-time monitoring of patient health, in which sensors collect data from patients with less human errors. In IoT, the patient's parameters get transmitted through medical devices via a gateway to the centralized system, where it is stored and analyzed.

Objective:

In this paper, we have proposed an intelligent patient monitoring system for monitoring the patients' health condition automatically through sensors-based connected links. The system is more intelligent that it can be able to detect the critical condition of a patient by processing sensor data and instantly provides a notification to doctors/nurses as well as hospital in-charge personnel. The doctors and nurses get benefited from this system by observing their corresponding patients remotely without visiting to the particular seat of the patient.

Methods:

An idea has been proposed to use the centralized processing of IoT devices along with the rigid security and privacy of the classical blockchain to overcome the computation expense challenge with blockchain and the security and privacy threat of the IoT systems. We are developing a system in the field of medical care to enhance the functioning of Medicare systems and provide patients with more ease and hassle-free procedures of the Medicare system, i.e., hospitals, laboratories, dispensaries, chemists, druggists, etc.

Results:

This model helps in getting rid of this issue faced by all of us. There is a separate blockchain of different verified medical stores linked within the networks, which will be managed by the central hub based on their ratings, reviews, and stock availability.

Conclusion:

The exponential expansion of blockchain technology in healthcare is also astonishing and has a tremendous impact on the industry. By assessing prior activities, the idea is proposed to use a centralized database system with more privacy and security to gap between the healthcare industry and blockchain technologies has been addressed in this paper.
Energy Treasure Hunts
Authors:   Barry Consulting Services LLC, Barry John
Published: October 2022

This discussion will highlight the steps necessary to find energy savings opportunities within any type of processing facility.  An Energy Treasure Hunt or €œKaisen€ is a three day, plant-wide activity (but can take up to 5 days for large facilities) that focuses on:< ![if !supportLists] >1                 < ![endif] >Low cost and no cost actions to reduce energy consumption< ![if !supportLists] >2                 < ![endif] >Learning ways to continuously improve and reduce energy consumption< ![if !supportLists] >3                 < ![endif] >Brainstorming ways to reduce energy use throughout the facility 4                 < ![endif] >Identifying, analyzing and evaluating energy savings opportunities by observing daily operations 5                 < Quantifying those opportunities for energy reduction using a standard methodology and calculationFacility employees implement the Energy Treasure Hunt process with the aid of outside energy experts.The purpose of an Energy Treasure Hunt is to:< ![if !supportLists] >1                 < ![endif] >Combine knowledge from other plants, suppliers, consultants< ![if !supportLists] >2                 < ![endif] >Go and see, listen and smell< ![if !supportLists] >3                 < ![endif] >Identify energy use in the facility< ![if !supportLists] >4                 < ![endif] >Conceive new ideas and share exiting ones< ![if !supportLists] >5                 < ![endif] >Find new ways to save< ![if !supportLists] >6                 < Increase energy awarenessOnce the Energy Treasure Hunt has been completed, the facility is responsible to implement the projects that meet the necessary return on investment.
Evaluation of an alternative low-resource soy protein production method
Authors:   University of Illinois At Urbana Champaign, Gulkirpik Ece , Andrade Laborde Juan ,   University of Florida, Nowakunda Kephas ,   National Agricultural Research Laboratories
Published: October 2022

Mechanically expelled soy cake (MESC) is a valuable source of protein and other nutrients; however, this product stream is underutilized for human consumption, especially in low-resource settings such as the Sub-Saharan Africa (SSA) region. Additionally, MESC still contains oils, which are prone to oxidation. Through collaborative partnerships with scientists like Dr. Keshun Liu, USDA, ARS, and Dr. Kephas Nowakunda, NARL, we piloted a low resource method to make soy protein concentrate (SPC) that can be widely used by processors in developing economies. Using this method, oil content, oxidized byproducts, phytic acid, and oligosaccharides are reduced, while increasing protein content to almost 63% db. In this session, we demonstrate an alternative low-resource method to produce SPC from MESC and evaluate their nutritional quality and oxidative stability. We also present early sensory findings and hypothesize on potential uses and benefits of SPC products and ingredients in emerging markets. The SPC materials produced were characterized based on their protein, oil and phytic acid contents. Thiobarbituric acid reactive species using malondialdehyde (MDA) as standard and peroxide value were assessed in SPC meal and oil extracted from SPC, respectively, to evaluate oxidation status in comparison with raw materials.With this alternative less resource-demanding method, SPC with a protein content of ~63% db and with lower oil (50% less) and phytic acid (70% less) contents and higher stability due to lower peroxide value (50% less) and MDA (50% less) contents than the original MESC can be made from defatted or low-fat soy flour using locally-available materials and equipment. This is beneficial because with this alternative method, the utilization of SPC for human consumption in SSA can be improved by expanding its incorporation into various food products including extruded snacks, composite flours, porridges, and bakery products.
Organic solvent nanofiltration membrane for vegetable oil refining
Authors:   Seppure Ptd Ltd, Davood Abadi Farahani Mohammad Hossein
Published: October 2022

Membrane separation technology has been receiving much attention for processing vegetable oils due to its potential advantages over conventional purification techniques. Based on the molecular weights and their interactions with the membrane, various solutes can be removed or purified using this technology. However, one of the major challenges is that the membrane has to be chemically inert to organic solvents such as hexane or acetone. Thus, many studies have been focused on developing chemically resistant membranes for specific industrial applications. Organic solvent nanofiltration (OSN) membranes is one of the potential energy efficient and sustainable separation processes that can drastically change the way solvents are recovered and free fatty acids (FFA) are removed in the vegetable oil industry. Seppure's patented GreenMem Series can process vegetable oil in acetone and hexane, achieving high product purity at relatively mild conditions (25 €“ 60°C, 10 €“ 30 bar). This results in up to 90% lower energy consumption and CO2e emissions as well as up to 30-50% lower operating costs compared to the conventional separation processes. GreenMem Series membranes show a high pure solvent flux of 30 €“ 40 LMH for acetone and hexane as well as high rejection towards oil molecules >95%. Moreover, 99% of FFA can be removed from a solvent/FFA mixture using multi-pass filtration system, which can be implemented in a unique membrane system to separate oil/FFA/solvent from each other. Moreover, GreenMem system can be implemented in both continuous and batch processes. Just like many other membrane technologies, its modularity makes it easy to be scaled up based on production capacity to augment existing processes. It is envisioned that OSN technology provides both positive economic and environmental impacts on the vegetable oil industry.
Maintaining Compliance with Combustible Dust Regulations
Authors:   ADF Engineering, Williamson Matthew
Published: October 2022

Since the deadline for completion of Dust Hazard Analyses has passed per NFPA 652, implementation of the identified dust hazard controls must be completed and the DHA program must be maintained.   Some dust hazard mitigation requirements may be challenging or too costly to implement, especially in truck loadout bays and banks of concrete silos, where common dust protection equipment may not be sufficient to mitigate the hazards.               How can concrete silos with common walls and feed systems be effectively isolated?  How can large dust clouds generated while loading meal into trucks be sufficiently suppressed?   What happens if you do not have a Dust Hazard Analysis in place and how do you maintain it once you do?   What further changes are coming to the combustible dust standards?   This presentation will address effective dust control, aspiration best practices, and risk mitigation strategies, as well as DHA compliance strategies and future direction for the standards.
Process Management
Authors:   Blind Corner Solutions LLC, German Brent
Published: October 2022

A discussion of process management philosophy and technique with general goals of reducing on-site manager time and off-hours call-ins. This is intended for new supervisors and others who need to break the “too many hours at work” and “too many call-ins” cycle—and still exceed corporate standards & goals.
A world first funded by the European Union: adaptation and startup of an U.K. hexane extraction plant to run on a 100% biobased solvent.
Authors:   Pennakem Europe, Jacques Laurence , Bartier Mickael
Published: October 2022

The 2-methyloxolane is a 100% biobased solvent produced and sold by Pennakem under the name EcoXtract®. It is a low carbon footprint, low toxicity, lipophilic liquid which has been used for more than 15 years in the pharma industry and which is currently under review for food use in Europe and in the US. In 2021, Pennakem Europa, together with 4 european partners and a financial support from the European Union, adapted a 10 Tons/day Crown plant located in U.K., New Holland Extraction, to the 2-methyloxolane. The plant successfully started on a soy campaign in October 2021 and produced oil with less 1 ppm solvent and a well defatted meal (< 1%). The presentation will describe the main plant modifications and the results of the campaign. New Holland Extraction is now able to run with hexane or with the 2-methyloxolane to support the process optimization and pave the path to the conversion of larger plants.
Farmers' Social Capital in Supporting Sustainable Agriculture: The Case of Pujon Kidul Tourism Village, Indonesia
Authors: Nugraha Achmad , Prayitno Gunawan , Rahmawati Rahmawati , Auliah Aidha
Published: October 2022

Pujon Kidul Village is a village with the potential of the main agricultural sector which has been designated and developed into a Pujon Kidul Tourism Village. Tourism villages that are developed need support within the village itself to maintain sustainability. Tourist villages that do not pay attention to the sustainability aspect will threaten the social and economic conditions of the community, especially the farming community, who make up most rural communities. Therefore, it is necessary to support sustainable agriculture that can balance sustainable tourism. The most important capital that must be prepared to achieve sustainable agriculture is social capital from the farming community. Social capital is the main force to empower communities in development, this study examines how the conditions and factors are forming the social capital of the farming community of Pujon Kidul tourism village. This study's main data collection method used a questionnaire aimed at 221 respondents. Then the questionnaire results will be described and analyzed by CFA analysis. Overall, the social capital of the farming community is in good condition, and this is a potential that can be used in determining the right approach to the farming community of Pujon Kidul Tourism Village in supporting sustainable agriculture
Rationalization of Rainfall Station Density in the Jatiroto Sub-Watershed Using Ground and Satellite Rainfall Data
Authors: Megantara Anggit , Wahyuni Sri , Limantara Lily
Published: October 2022

This study uses ground and CHIRPS data to rationalize the density of rainfall stations in the Jatiroto Sub-watershed, Lumajang Regency. This study aimed to determine the suitability of the CHIRPS satellite rainfall data to the measurement data. In addition, it determines the density of rainfall stations based on WMO standards. Also, the Kagan-Rodda method uses measurement and satellite data to determine rainfall station recommendations' results. The method used for the suitability test uses the value of RMSE, NSE, Correlation Coefficient, and Relative Error. And the WMO standard for analyzing the number of rainfall station. Knowing the rationalization and recommendations for placing rainfall stations using the Kagan-Rodda method by considering WMO standards, root mean square error, and interpolation errors. The results obtained include the appropriateness of satellite data, the number of rainfall stations at the research location according to WMO standards, and recommendations for rainfall stations based on Kagan-Rodda
The role of Kompas.id platform as a forum for the development of newspaper literature in the digital era
Authors: Ayuningrum Annisa Dwi , Larasati Ade Kurnia Putri , Putri Syaimah Kusnari , Bachtiar Ahmad
Published: October 2022

The newspaper has long been an outlet for publishing written work, and through technological breakthroughs that have impacted and advanced the publishing industry, the readers benefit from online newspapers. This digital media makes possible simple and rapid access to digital information channels, including the news portal Kompas.id. The present study, library research, aims to reveal the newspaper literature that promotes an appreciation for Indonesian literature. Screenshots and attentive listening were employed as documentation strategies during the data collecting process which involve some analysis of literary content on Kompas.id. The researcher's technical analysis includes the following steps: (1) Identifying literary products pertinent to the investigation, (2) accessing the Kompas.id software, (2) registering for a user account on the Kompas.id website, (3) attentively listening to the literary works read on the Kompas.id platform, (5) examining the literary content on the platform, and (6) summarizing and presenting the findings. The results of the study demonstrated that newspaper literature relatively evolved in this digital era, making it simpler for authors to submit their works and for readers to enjoy them. The Kompas.id, site publishes literary pieces that serve to enlighten, educate, and transmit moral values to their readers, as well as stimulating their interest on reading through its up-to-date and original works of literature This likely exemplifies how the growth of digital media has influenced Indonesian literature in a beneficial way.Keywords: newspaper literature, Kompas.id, technology, digital era
PERSEPSI MAHASISWA TERHADAP PENGGUNAAN VIDEO KONSTRUKSI POLA PADA PROGRAM STUDI TATA BUSANA
Authors: Istanti Hanifah Nur
Published: October 2022

Penelitian ini dilakukan untuk mengetahui pendapat mahasiswa Program Studi Tata Busana Program Sarjana Terapan Universitas Negeri Yogyakarta Angkatan 2021 terhadap video konstruksi pola. Metode penelitian yang digunakan adalah metode penelitian survei dengan jenis penelitian deskriptif dengan pendekatan kuantitatif. Instrumen penelitian yang digunakan adalah kuisioner dengan teknik analisis data deskriptif kuantitatif. Sampel penelitian adalah mahasiswa Program Studi Tata Busana Program Sarjana Terapan Universitas Negeri Yogyakarta Angkatan 2021. Data yang sudah terkumpul kemudian dianalisis dan dikategorikan menggunakan skala interval data yakni Sangat Baik, Baik, dan Tidak Baik. Hasil penelitian menunjukkan bahwa (1) persepsi mahasiswa terhadap media video dalam kategori baik digunakan dalam pembelajaran, (2) persepsi mahasiswa terhadap materi video dalam kategori sangat baik digunakan dalam pembelajaran, dan (3) persepsi mahasiswa terhadap video dalam kategori sangat baik digunakan dalam pembelajaran. Penelitian ini dapat disimpulkan bahwa video pembelajaran konstruksi pola dibutuhkan oleh mahasiswa agar dapat digunakan sesuai dengan kemampuan mahasiswa serta memudahkan mahasiswa dalam mengerjakan tahapan pembuatan konstruksi pola.
PENGARUH BUKU CERITA BERGAMBAR TERHADAP KEMAMPUAN MEMBACA PEMAHAMAN DAN HASIL BELAJAR SISWA
Authors: Suprapto Hidayah Mulyaningsih
Published: October 2022

Penelitian ini bertujuan untuk mengetahui: (1) pengaruh penggunaan media buku cerita bergambar terhadap kemampuan membaca pemahaman siswa kelas IV sekolah dasar, (2) pengaruh penggunaan media buku cerita bergambar terhadap hasil belajar siswa kelas IV sekolah dasar, dan (3) pengaruh penggunaan media buku cerita bergambar terhadap kemampuan membaca pemahaman dan hasil belajar siswa kelas IV.Penelitian ini merupakan penelitian kuasi eksperimen dengan desain Pretest-Posttest Non-Equivalent Control Group Design. Populasi dalam penelitian ini adalah siswa kelas IV SD N se-Kecamatan Prambanan Sleman, Yogyakarta yang telah menerapkan Kurikulum 2013. Sampel penelitian adalah 84 siswa SD Negeri Delegan 2, SD Negeri Delegan 3, dan SD Negeri Dadapsari.  Sampel penelitian dibagi menjadi kelas eksperimen dan kelas kontrol dengan teknik cluster random sampling. Kelas eksperimen menggunakan buku cerita bergambar dan kelas kontrol menggunakan buku kurikulum 2013. Kelas eksperimen berjumlah 56 siswa dan kelas kontrol berjumlah 28 siswa. Instrumen yang digunakan untuk mengukur kemampuan membaca pemahaman dan hasil belajar siswa adalah lembar kuisoner tes tertulis. Teknik analisis menggunakan uji Paired Sample t-Test dengan taraf signifikansi 0,05Hasil penelitian menunjukkan bahwa: (1) buku cerita bergambar berpengaruh terhadap kemampuan membaca pemahaman siswa dengan hasil nilai Sig (2-tailed) pada kelas eksperimen diperoleh nilai t hitung (9,346) t tabel (2,05) dan, (2) buku cerita bergmbar berpengaruh terhadap hasil belajar, dengan uji t menunjukkan nilai t hitung (13,914) t tabel (2,05).   Simpulan yang dihasilkan adalah bahwa buku cerita bergambar berpengaruh terhadap kemampuan membaca pemahaman dan hasil belajar siswa kelas IV sekolah dasar. Hasil uji efektifitas diketahui persentase peningkatan pada kelas eksperimen mempunyai peningkatkan lebih baik dibandingkan kelas kontrol. Kata Kunci : buku cerita bergambar, kemampuan membaca pemahaman, hasil belajar
Evaluating the compatibility between Indonesian language teachers’ competence, their needs, and in-service training’s effectiveness
Authors: Wijaya Henry , Juniarmi Veronica Christamia , Tehusalawany Christa A. Y.
Published: October 2022

BIPA’s growth is observable from APPBIPA’s expansion, teachers dispatch to various countries, and the soaring number of host institutions. The growth, which leads to the escalating number of teachers, needs to be met with elevated competence, whereas the mushrooming in-service training requires critical evaluation to ensure impactful results. This research examines the compatibility between teacher’s standard of competence, what they need to attain it, and the effectiveness of training programs in bridging those two. While generally satisfied with the training topics, methods, content, and trainer, the participants still deemed those aspects to be not fully compatible with their needs, nor to be fully effective in achieving the competence standard. Considering its importance, in-service BIPA teacher training not just exist but lack of/without meaningful impacts. Finally, the writers expect the results of this study to inform more effective BIPA training programs in the future.Keywords: competence, teachers training, in-service, evaluation, effectiveness
Utility of the Comprehensive Health and Stringency Indexes in Evaluating Government Responses for Containing the Spread of COVID-19 in India: Ecological Time-Series Study
Authors: Kishore Kamal , Jaswal Vidushi , Pandey Anuj Kumar , Verma Madhur , Koushal Vipin
Published: October 2022

Background

Many nations swiftly designed and executed government policies to contain the rapid rise in COVID-19 cases. Government actions can be broadly segmented as movement and mass gathering restrictions (such as travel restrictions and lockdown), public awareness (such as face covering and hand washing), emergency health care investment, and social welfare provisions (such as poor welfare schemes to distribute food and shelter). The Blavatnik School of Government, University of Oxford, tracked various policy initiatives by governments across the globe and released them as composite indices. We assessed the overall government response using the Oxford Comprehensive Health Index (CHI) and Stringency Index (SI) to combat the COVID-19 pandemic.

Objective

This study aims to demonstrate the utility of CHI and SI to gauge and evaluate the government responses for containing the spread of COVID-19. We expect a significant inverse relationship between policy indices (CHI and SI) and COVID-19 severity indices (morbidity and mortality).

Methods

In this ecological study, we analyzed data from 2 publicly available data sources released between March 2020 and October 2021: the Oxford Covid-19 Government Response Tracker and the World Health Organization. We used autoregressive integrated moving average (ARIMA) and seasonal ARIMA to model the data. The performance of different models was assessed using a combination of evaluation criteria: adjusted R2, root mean square error, and Bayesian information criteria.

Results

implementation of policies by the government to contain the COVID-19 crises resulted in higher CHI and SI in the beginning. Although the value of CHI and SI gradually fell, they were consistently higher at values of >80% points. During the initial investigation, we found that cases per million (CPM) and deaths per million (DPM) followed the same trend. However, the final CPM and DPM models were seasonal ARIMA (3,2,1)(1,0,1) and ARIMA (1,1,1), respectively. This study does not support the hypothesis that COVID-19 severity (CPM and DPM) is associated with stringent policy measures (CHI and SI).

Conclusions

Our study concludes that the policy measures (CHI and SI) do not explain the change in epidemiological indicators (CPM and DPM). The study reiterates our understanding that strict policies do not necessarily lead to better compliance but may overwhelm the overstretched physical health systems. Twenty-first–century problems thus demand 21st-century solutions. The digital ecosystem was instrumental in the timely collection, curation, cloud storage, and data communication. Thus, digital epidemiology can and should be successfully integrated into existing surveillance systems for better disease monitoring, management, and evaluation.
Utilization of and satisfaction with a mobile health application during the COVID-19 pandemic in Thailand (Preprint)
Authors: Kittipimpanon Kamonrat , Noyudom Angun , Panjatharakul Pawanrat , Visudtibhan Poolsuk Janepanish
Published: October 2022

BACKGROUND

RamaCovid is a mobile health application that provides the Thai population with information about COVID-19 and self-risk assessment. RamaCovid has a chatbot system that provides automatic conversations (available 24 hours per day) and a live chat function that allows users to directly communicate with health professionals (available 4 hours per day in the evening).

OBJECTIVE

This study investigated users’ utilization of and satisfaction with the RamaCovid application.

METHODS

Overall, 400 people were included and were recruited via RamaCovid by broadcasting an infographic about the study. Questionnaires collected demographic data, users’ experiences of RamaCovid, and the utilization of and satisfaction with the application. The questions were answered via a 5-point Likert scale.

RESULTS

The users had high utilization and satisfaction with the application. They used the information to take care of themselves and their family, and they gained information about their COVID-19 risk. The users were satisfied with the application because the information was easy to understand, trustworthy, and up to date.

CONCLUSIONS

RamaCovid provides an example of the successful implementation of an educational mobile health application. It facilitates the communication of trustworthy and up-to-date information and has enhanced people’s ability to take care of themselves and their family during the COVID-19 pandemic.
Ứng dụng Matlab App Designer thiết kế chương trình mô phỏng định vị sự cố trên đường dây tải điện dựa trên các phương pháp tổng trở
Authors: Ngô Minh Khoa , Mai Vũ Cường , Huỳnh Quốc Cường , Nguyễn Trương Tấn Hiếu
Published: October 2022

Matlab App Designer được ứng dụng trong nghiên cứu để thiết kế chương trình mô phỏng định vị sự cố trên đường dây tải điện. Các phương pháp được sử dụng để xác định vị trí sự cố dựa trên các phương pháp tổng trở. Các phương pháp đó sử dụng dữ liệu đo lường điện áp và dòng điện từ một và hai đầu đường dây. Chương trình được thiết kế trong bài báo này mang tính tổng quát cao, có thể áp dụng cho nhiều đường dây cấp điện áp khác nhau, khảo sát toàn diện cho bốn dạng sự cố ngắn mạch tại các vị trí và tổng trở sự cố thay đổi dọc theo chiều dài đường dây. Ngoài ra, chương trình mô phỏng được đóng gói thành file chạy *.exe nên có thể cài đặt ở bất kỳ máy tính mà không cần thiết phải có phần mềm Matlab để tiến hành mô phỏng. Trường hợp nghiên cứu đối với đường dây cấp điện áp 220 kV và 110 kV được áp dụng để khảo sát và đánh giá chương trình đã thiết kế. Các kết quả mô phỏng đã cho thấy được chương trình làm việc hiệu quả và chính xác.
Regulasi Emosi dan Penyesuaian Mahasiswa Baru Saat Pandemi: Pentingkah Dukungan Emosional Orang Tua?
Authors: Meganingtyas Yunissa , Mufitasari Dian
Published: October 2022

The Covid-19 pandemic has made new students of the class of 2020 experience three transitions at once in their lives. It takes a good ability to regulate emotions so that new students are able to pass the transition period successfully. This study aims to examine the role of emotion regulation on the ability to adjust to college during a pandemic through the emotional support of parents as moderators for new students. A total of 247 new students from the 2020 batch of Gadjah Mada University participated voluntarily in filling out the online questionnaire. There are three measuring tools used, namely the Emotion Regulation Scale, Student Adaptation to College Questionnaire (SACQ), and the Parental Emotional Support Scale. Moderation Regression Analysis was used to test the hypothesis and the results showed that parental emotional support was not proven to moderate the relationship between emotional regulation and college adjustment. However, emotion regulation was shown to have a direct positive effect on academic and social adjustment (p < 0.05).
Peran Pendidikan Profesi, Efikasi, dan Dukungan Sosial dalam Memprediksi Perilaku Inovatif Guru
Authors: Nandini Satwika Parama , Indrasari Stephanie Yuanita
Published: October 2022

Menjadi inovatif merupakan salah satu kunci keberlangsungan suatu organisasi, termasuk institusi pendidikan. Guru, sebagai pemegang peran krusial dalam institusi pendidikan juga amat perlu mengembangkan perilaku inovatif agar dapat mencapai tujuan pendidikan di abad ke-21. Studi korelasional dilakukan untuk meneliti apakah keikutsertaan pada pendidikan profesi, efikasi guru, dan dukungan sosial di sekolah memprediksi perilaku inovatif pada guru sekolah dasar di Jakarta, Bogor, Bekasi, dan Depok. Sebanyak 234 partisipan mengisi kuesioner self-report untuk mengukur ketiga variabel tersebut. Analisis regresi majemuk dilakukan untuk mengolah data yang diperoleh. Hasil penelitian menemukan bahwa ketiga variabel signifikan memprediksi perilaku inovatif guru, namun pada dimensi yang berbeda-beda dari perilaku inovatif guru. Selain itu, dukungan sosial ditemukan menjadi kontributor terbesar dalam memprediksi perilaku inovatif guru. Implikasi dari hasil yang ditemukan menunjukkan urgensi pengembangan aspek pendidikan, personal, dan sosial guru agar dapat menerapkan perilaku inovatif dalam kesehariannya.
Huacas de Moche
Authors: Rengifo Chunga Carlos , Gayoso Rullier Henry , Castillo Luján Feren
Published: October 2022

Scientific and popular knowledge traditionally associates the iconic Andean archeological site of Huacas de Moche —also known as Huacas del Sol y de la Luna—with the Mochica, or Moche, culture. They say that Huacas de Moche was a city that concentrated the power of a state with ideological and political influence on the northern coast of Peru between 100 and 850 AD. The archaeological remains of the ancient adobe settlement, however, indicate that this is only part of the story and that different cultural groups occupied the site before and after the Mochicas over a period of approximately two thousand years. Based on the available archaeological evidence, this paper describes and analyzes the occupation history of Huacas de Moche, focusing on lesser-known periods and examining how these different communities modified the natural and cultural landscape during their occupations.
Data Visualization and Analysis of COVID-19 Data
Authors: Keswani Hrishikesh , Shah Krishit , Hassani Hritik , Gadkar Moses , Kavedia Er. Manoj
Published: October 2022

Abstract: During the COVID-19 pandemic, many data visualizations were created to alert the public to the rapidly growing threat. Statistics on the spread of COVID-19 have been displayed on data dashboards, a mechanism for sharing information throughout the pandemic, which has aided in this process. When developing the visuals for COVID-19, the majority of time was spent on the technical aspects of designing and evaluating various visualization methods. Little is understood about the inner workings of visualization production processes due to the complex sociotechnical environments in which they are embedded. However, such ecological data is necessary for identifying the particulars and tendencies of visualization design practices in the wild and generating insights into how artists learn to perceive and approach visualization design on their terms and for their contextual aims. We conducted in-depth interviews with dashboard designers from federal and state health departments, major news media outlets, and other firms that created (often widely used) COVID-19 dashboards to gain insight into the following areas. What kind of problems, disagreements, and conflicts arose during making the COVID-19 dashboard because of the participation of visualization creators? The trajectory of design practices—from genesis to expansion, maintenance, and termination—is determined by the complex interconnections between design goals, design tools and technologies, labour, emerging crisis circumstances, and public participation. We zeroed in on these procedures' tensions between designers and the general public. Conflicts frequently arose due to a chasm between public demands and prevailing policies. They typically centred on the types and amounts of information that should be visualized and how public perceptions shape and are shaped by visualization design. The strategies used to deal with (potential) misinterpretations and misuse of visualizations. Our findings and takeaways offer fresh viewpoints on visualization design by highlighting the bundled activities typically linked with human and nonhuman participation along the entire trajectory of design practice
Comunicación interna: caracterización y análisis de trabajo realizado por empresas que pertenecen a ranking Great Place to Work Chile
Authors: Claro Cecilia , Ayala de Choriego Marilena , Barros Juan Pablo
Published: October 2022

Los cambios en los modos de trabajar en las organizaciones impulsados por la pandemia por la COVID-19 y las restricciones de movimiento, generaron adaptaciones en las formas de comunicar a los diferentes públicos con los que se relacionan las instituciones, en particular en el modo de interactuar con los públicos internos. Esta investigación tiene como objetivo observar el impacto en el estado, funcionamiento y ajustes en la comunicación interna en pandemia. Para esto se observaron organizaciones en Chile pertenecientes al ranking Great Place to Work® 2020 (GPTW 2020). El análisis se hizo cinco meses después de iniciada la crisis sanitaria. Esta investigación de tipo exploratorio utilizó un cuestionario autoadministrado que fue aplicado a través de mailing y teléfonos a las instituciones presentes en el ranking Great Place to Work®. Entre los principales resultados se puede destacar que la comunicación interna es un actor relevante de desarrollo en las organizaciones, sobre todo en tiempos de crisis. Esto se confirma porque el 88 % de las empresas cuenta con un área exclusiva para la comunicación interna, las que producto de la pandemia debieron cambiar su foco desde capacitación, beneficios y reconocimientos al personal en 2019, a contención de crisis externa, seguridad y prevención de accidentes laborales en 2020. Tras el análisis, es posible vislumbrar cambios institucionales, reorganización interna y temas emergentes como work-life balance, trabajo en equipo, COVID y cuidado de los trabajadores.
Narraciones de las experiencias de los estudiantes en contexto de cambio curricular
Authors: Alvarado-Guerrero Irma Rosa , Rodriguez-de-la-Rosa Maria Esther , Del-Bosque-Fuentes Ana Elena , Cepeda-Islas María Luisa , Vega-Valero Cynthia Zaira
Published: October 2022

En los espacios escolares de nivel universitario se plantea reconocer el abordaje de las experiencias e indagar desde la voz de los estudiantes. Este trabajo se centra en la investigación de la experiencia individual de estudiantes de la carrera de psicología generación 2017 de la FES Iztacala en un contexto de cambio curricular. Se indagó a través de la entrevista narrativa y el grupo focal la apreciación de 17 estudiantes que se encontraban cursando el sexto de ocho semestres. La perspectiva de análisis se realizó desde un acercamiento cualitativo-interpretativo de la experiencia vivida durante sus estudios. Se desarrollaron tres categorías a partir del análisis vertical y horizontal de las transcripciones: 1. Involucramiento en la carrera, 2. Acciones y actividades para desempeñarse en la carrera y 3. Estrategias de aprendizaje. El análisis muestra las opiniones que ubicaron los participantes en su paso por la carrera, así como los actores educativos reconocido como relevantes en su proceso de formación y los elementos que pusieron en juego en la toma de decisiones. Se identifica una escucha reflexiva del estudiante y toma de decisiones responsable a favor de su aprendizaje y desarrollo autodidacta.
Little Do They Know
Authors: Olivia Rowland
Published: October 2022

This exposition functions as both a visual and poetic essay, and a manifesto for my methodology of ‘line’. My definition of ‘line’, defined here as:

‘The gestural and abstracting tandem force of drawing-and-writing as a narrative means to express selfhood.’

The exposition posits the methodology of ‘line’ as one alternate artistic means to artistically communicate feminine selfhood. The methodology of line works to resist the internalised assignment of feminine voice to a corporeal body.

Instead, ‘line’ communicates selfhood through poetic means and a sense of fragmented corporeality. Visually, the stark and abstracting nature of the drawn line, and the allegorical, metaphorical nature of writing present an abstracted self that playfully evades full understanding.

The titling phrase ‘Little Do They Know’ intones a kind of secret power on behalf of the speaker, and the presence of secret and intricate worlds to which the gaze of the spectator has limited access. It is on this premise which the exposition operates, articulating the presence (in all its anxiety, instability, rage, joy and frustration) of a playful and evasive selfhood that reclaims agency from the spectator’s gaze.