bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of organophosphorus pesticide residue content in brinjal and cucumber vegetables in the Narsingdi district in Bangladesh
Authors: Mahjabin Tasnima , Razzak Md. Abdur , Rahman Matiur , Ahmmed Abu Noman Faruq , Ferdous Raihan
Published: February 2025

This study investigated the prevalence of organophosphorus (OPs) pesticide residues in brinjal (eggplant) and cucumber samples collected between September 2021 and June 2022 in Narsingdi District, Bangladesh. A total of 36 unwashed vegetable samples (18 samples of brinjals and 18 samples of cucumbers) were collected from three sources, namely farmers' fields, retail markets and a controlled export zone. The samples were analyzed for residues of four OPs pesticides, viz. diazinon, dimethoate, malathion and chlorpyrifos, using the QuEChERS method followed by Gas Chromatography-Mass Spectrometry (GC/MS) technology. The results revealed a concerning level of pesticide contamination, particularly with dimethoate. Over half (58%) of all samples contained dimethoate, of which more than a third (39%) exceeded the European Union's Maximum Residue Limits (MRL). Chlorpyrifos was also detected in 50% of the samples, but only 8% of the samples exceeded the MRLs. Malathion residues were found in a small number of samples (11%), all of which were within the MRLs. Notably, diazinon was not detected in any of the samples. Cooking (boiling at 100°C for 30 minutes) reduced the pesticide content in some samples, but this was not always sufficient to bring the pesticide content below the MRLs. This highlights the limitations of cooking as a sole decontamination method. Encouragingly, no pesticide residues were found in samples collected from the export zone, indicating stricter adherence to regulations in these controlled environments. These findings highlight the potential health risks such as nervous system disorders, vomiting, blurred vision, coma, etc. and even death associated with consuming vegetables contaminated with pesticide residues above the recommended limits. These factors emphasize the need for stricter regulations on the use of pesticide, the promotion of Integrated Pest Management (IPM) techniques and consumer education on safe prewashing practices.
The Chicago child-parent center early-childhood program: A critical appraisal
Authors: Driessen Geert
Published: February 2025

Early Childhood Education and Care (ECEC) interventions are often the core of policies to tackle educational disadvantage. They target socio-economically disadvantaged children and aim to improve their educational and life chances by providing compensatory stimulation activities in education institutions and at home. Many intervention programs have been developed and implemented since the 1960s. Three renowned so-called model programs are Perry Preschool, Abecedarian, and the Chicago Child-Parent Center (CPC). Though they date from the 1960s, 1970s, and 1980s, respectively, they are still often cited today as evidence that such programs are highly effective and that their effects can be generalized to later ECEC programs. This article focuses on the CPC and – if possible – makes comparisons with Perry and Abecedarian. The main question is whether this program really leads to positive effects, and if it does, whether these effects can be generalized to other, similar programs today. To find an answer to this question, a critical literature study was conducted, using the snowball method. On the basis of the hundreds of studies examined, it was concluded that, indeed, CPC yielded many positive effects in the domains of education, work, well-being, health, and crime. At the same time, several limitations were found, which seriously restricts its generalization.
Advancements in Maxillofacial Reconstruction: Design and Manufacturing using Electron Beam Powder Bed Fusion (PBF-EB/M)
Authors: Szymczyk-Ziółkowska Patrycja , Rusińska Małgorzata , Ziółkowski Grzegorz , Kobiela Karol , Sekuła Kinga , Kęszycki Dawid , Miner-Kordasiewicz Anna
Published: February 2025

Objective: Maxillofacial injuries often necessitate complex reconstructive surgeries, requiring the design and fabrication of patient-specific implants (PSIs) to restore functionality and aesthetics. A 32-year-old male patient, who sustained a mandible injury, served as a case study.
Methods: This study presents advancements in maxillofacial reconstruction through the application of Electron Beam Powder Bed Fusion (PBF-EB/M), an additive manufacturing (AM) technique, in the creation of personalized jaw implants. CT scans were processed to develop a 3-D model of the patient's tissues, and Finite Element Analysis (FEA) was employed to assess mechanical behaviour.
 Results: The PSI, manufactured from a Ti6Al4V ELI alloy, exhibited suitable mechanical properties and biocompatibility. This work presents a workflow that clarifies the principles of designing, verifying and manufacturing PSIs for maxillofacial reconstruction.
Conclusions: By integrating advanced imaging techniques, FEA simulations, and AM technologies, along with post-processing using CAM tools, the feasibility of producing personalized medical devices with modern manufacturing methods that offer enhanced design flexibility can be assessed. This includes highlighting both the potential benefits and challenges of the proposed approach.
Image-Guided FLASH ProtonTherapy. A dream? Naivety?Arrogance? Or a Necessity?
Authors: Lang Karol
Published: February 2025

Objective: The in-vivo therapy guidance by imaging and dosimetry of proton irradiations, generically known as proton range verification, are some of the most underinvested aspects of radiation oncology. They trail behind other advances in radiation therapy due to the scarcity of sensitive instruments compounded by the lack of treatment protocols for precision monitoring of effects of beam radiation. This is despite that such measurements may dramatically enhance the treatment accuracy and lower the postradiation toxicity, thus improving the entire outcome of cancer therapy.
Methods: In this contribution, we focus on the motivation of designing and building of an in-beam time-of-flight (ToF) positron-emission-tomography (PET) scanner with the depth-of-interaction (DoI) capability for high sensitivity and improved fidelity of imaging. A scanner could be augmented with a tungsten collimator that would enable prompt-gamma imaging (PGI) via single-photon emission computed tomography (SPECT) technique.
Results: We present selected results of our pre-clinical experiments with a FLASH proton beam and discuss other related ideas towards improving and expanding the use of PET/PGI/SPECT detectors for proton therapy. A scanner provides an access to data during the spill and past the spill permitting to capture the beam interaction and kinetic monitoring of its effect thus allowing a thorough assessment of each irradiation.
Conclusions: A novel scanner for multiple modalities can substantially improve the treatment precision of proton therapy leading to less toxic outcome of irradiations. Using it in the FLASH modality would additionally expand the patient reach of proton therapy.
Badania nad możliwością obniżenia stężenia pyłu frakcji PM10 i PM2,5 w procesie wizualizacji śladów linii papilarnych lekkim proszkiem daktyloskopijnym — argentoratem
Authors: Szajna Arkadiusz Paweł , Paukszto Andrzej , Będkowski Mirosław , Osmoła Paweł
Published: February 2025

Za cel niniejszej pracy obrano zaprezentowanie wyników badań, przeprowadzonych w laboratorium kryminalistyki nad skutecznością stanowiska do ujawniania śladów daktyloskopijnych proszkami daktyloskopijnymi na podłożach niechłonnych (SDU - 513), w zakresie zwiększenia bezpieczeństwa osób narażonych na szkodliwe działanie pyłów podczas wizualizacji ww. śladów proszkiem lekkim — argentoratem. Autorzy udowadniają, że sprzęt z włączonym wentylatorem obniża wielokrotnie stężenie pyłu zarówno frakcji PM10, jak i PM2,5 w powietrzu nad jego powierzchnią roboczą. Podkreślają oni również, że stanowisko SDU - 513 nie eliminuje całkowicie zagrożenia związanego m.in. z dostaniem się pyłu do płuc. Mając powyższe na uwadze, w podsumowaniu publikacji zaprezentowane zostały rekomendacje dla osób obsługujących wspomniane urządzenie, aby zapewnić im bezpieczne i higieniczne warunki pracy.AbstractThe aim of this paper is to present the results of a study, carried out in a forensic science laboratory, on the effectiveness of a station for fingermark development with fingerprint powders on nonporous substrates (SDU – 513), in terms of increasing the safety of persons exposed to the harmful effects of dust during the visualization of the above-mentioned traces with a light powder – argentorate. The authors demonstrate that the fan-activated equipment repeatedly reduces the concentration of dust fractions PM10 as well as PM2.5 in the air above its working surface. They also stress that the SDU – 513 station does not completely eliminate the risk of, among other things, dust entering the lungs. With the above in mind, they conclude the article with a series of recommendations to ensure safe and hygienic working conditions for the operators of the said equipment.ResumenLos desafíos cambiantes para mantener la seguridad del Estado, la transformación de la estructura demográfica de la sociedad hacen necesario ampliar e intensificar los esfuerzos para dotar al Estado de una defensa y disuasión eficaces. A lo largo de los años, Polonia ha llevado a cabo programas destinados a influir en el número y la calidad de las Fuerzas Armadas como uno de los elementos de la seguridad del país. El artículo presenta la correlación entre los programas introducidos de activación de la sociedad y la dinámica del aumento del número de las Fuerzas Armadas. Los análisis emergentes de las percepciones de los polacos sobre su implicación en la defensa de la patria indican la legitimidad de la introducción de nuevos programas que influyan en las actitudes sociales y den lugar a un aumento del número de las Fuerzas Armadas.
Lesiones hepáticas diagnosticadas por tomografía multifásica de abdomen en pacientes de 30 a 80 años
Authors: Solano-Brito Pablo José , Salazar-Alvarado Xavier Miguel , Lozada-Arias Johanna Elizabeth , Soliz-Zabala David Santiago
Published: February 2025

La tomografía computarizada de abdomen (TCA) ofrece una evaluación eficaz de lesiones focales hepáticas (LFH), en conjunto con la administración de medio de contraste intravenoso, lo que permite analizar de manera dinámica el comportamiento de lesiones en diferentes fases, así como la definición y caracterización. El objetivo fue analizar las LFH diagnosticadas mediante TCA, según el tipo de lesión, en relación con las variables, edad, género y localización anatómica. El estudio fue de tipo descriptivo transversal, basado en 159 informes imagenológicos de TCA de pacientes con edades entre 30 a 80 años, que fueron atendidos en el en el Instituto de Diagnóstico por Imagen, durante el periodo noviembre 2022 a marzo 2024. Se analizaron las variables edad, sexo, LFH y localización anatómica. Los datos se recolectaron mediante formularios, a partir de los registros institucionales anonimizados; para el análisis se emplearon estadísticos de frecuencia y porcentaje, utilizando el programa Excel 2019. De 159 informes imagenológicos, el 67% corresponde a quiste simple, 14% a hemangioma, el 13% son compatibles con absceso, y 6% con metástasis; la mayoría de las lesiones (66%) ocurren en mayores de 60 años, afectando principalmente al sexo femenino (60%), y ubicándose, en un mayor porcentaje (59%), en el lóbulo derecho del hígado. En conclusión, la mayoría de LFH detectadas son benignas, siendo el quiste simple el más frecuente, seguido del hemangioma, absceso y metástasis hepáticas. Se resalta la importancia de emplear correctamente la TCA que nos permite caracterizar las lesiones hepáticas benignas y malignas, lo cual es fundamental para el diagnóstico.
Perfil hematológico en loros cabeciazul (Pionus menstruus; Psittacidae) en cautiverio en el Zoológico “El Arca”, en la provincia de Napo, Ecuador
Authors: Alvear Gerardo Kelly , Carvajal-Villacres Luana
Published: February 2025

En esta investigación se determinó el perfil hematológico en loros cabeza azul en cautiverio en el Zoológico “El Arca”, cantón Tena, provincia de Napo, Ecuador. Se utilizaron 20 loros con aspecto saludable. Al examen semiológico, los loros mostraron buena condición corporal y peso adecuado, temperatura corporal dentro de los parámetros de la especie. Además, el examen físico de las narinas, ojos, pico, cabeza y la distribución de las plumas no mostró ninguna alteración. Las muestras sanguíneas fueron analizadas en un Autoanalizador hematológico PKL de uso veterinario. Los valores de frecuencia respiratoria y cardiaca estuvieron dentro de los rangos normales (102.1 lpm and 53.3 rpm), sin embargo, en algunos ejemplares los valores aumentaron debido al estrés por el manejo y sujeción. Los valores hematológicos fueron los siguientes: recuento total de eritrocitos 2,2 ±0,41x1012/L; hemoglobina 14,5 ± 3,18 g/dL, hematocrito 32,4 ± 6,88 %, VCM 149,0 ± 5,43 fL, HCM 66,1 ± 6,06 pg, CHCM 44,4 ± 3,08 g/dL, plaquetas 17,1 ± 7,33 10 x109/L, recuento total de leucocitos 17,5 ± 10,59 x109/L, heterófilos 21,4 ± 13,9 % o 3,43x109 L, linfocitos 29,4 ± 12,61% o 6,0 x109 L, monocitos 47,86 ± 15,64 % o 233x109 L, eosinófilos 0,9 ± 1,00 % o 0,13x109 L y basófilos 0,34 ± 0,35 % o 0,05 x109 L. Este es el primer reporte sobre los valores sanguíneos de P. menstruus en el Ecuador, por lo que estos podrían servir de base en la toma de decisiones en los protocolos de manejo de la especie.
Impacto del Aprendizaje Basado en Proyectos y la gamificación en el proceso de enseñanza - aprendizaje de la Lengua y Literatura
Authors: Pomaquiza-Saeteros Mirian Cecilia , Pomaquiza-Saeteros Nelly Graciela , Cacoango-Yucta Washington Iván , Maliza-Cruz Wellington Isaac
Published: February 2025

El presente estudio evaluó el impacto del Aprendizaje Basado en Proyectos (ABP) y la gamificación en el rendimiento académico de los estudiantes de décimo grado en Lengua y Literatura en la Unidad Educativa “Rafael Aguilar”. Se empleó un enfoque metodológico cuantitativo, dividido en dos grupos: uno experimental, que participó en actividades ABP y utilizó la plataforma Educaplay, y otro control, que no fue expuesto a estas metodologías. La investigación analizó el efecto inmediato de las intervenciones a través de encuestas a docentes y mediciones de rendimiento académico. Los resultados mostraron un desempeño superior y más homogéneo en el grupo experimental, evidenciado por calificaciones significativamente más altas en comparación con el grupo control. Además, se observó una menor dispersión en los puntajes del grupo experimental, lo que indica una mayor consistencia en los resultados. La encuesta a docentes reveló percepciones positivas sobre el impacto de las metodologías activas en la motivación y participación de los estudiantes, aunque se identificaron dificultades como la resistencia al cambio y la falta de recursos tecnológicos. En conclusión, el uso de ABP y gamificación mostró mejoras significativas en el aprendizaje, pero es esencial superar obstáculos estructurales y promover una mayor formación docente para maximizar su efectividad.
Filosofia da Química como um Fundamento Teórico da Educação Química
Authors: Marcos Antonio Pinto Ribeiro
Published: February 2025

A inclusão da Filosofia da Química, campo disciplinar emergente nos anos 1990, como item de avaliação no Enade pelo Inep, consolida o reconhecimento da importância que esta área possui para a Educação Química brasileira. Logo, é um tempo necessário para pensar contribuições deste marco epistemológico para o sistema pedagógico da Química, nomeadamente a Formação, Didática, Currículo e a Pesquisa. Para tal, explicitamos o debate da Filosofia da Química e aproximamos com a literatura em Educação Química para identificar problemas e questões genuínas da práxis Química. O conceito de Práxis é retirado das construções teóricas de Habermas e sua teoria dos interesses humanos básicos, que possibilitam pensar o interesse técnico, prático e emancipatório e suas adaptações ao currículo. No cruzamento das literaturas identificaram-se paradoxos, conflitos teóricos, falsos problemas, descrevendo um quadro de tensões e antinomias inscrita na práxis Química e ainda buscando descrever padrões didáticos da química inscrita na transmissão da própria História e Filosofia da Química. Um objetivo subjacente e condutor da pesquisa é encontrar novas perspectivas e visões sobre a práxis química e, por fim, uma construção de uma agenda renovada para a Educação Química. Finaliza por propor a formação de dois campos disciplinares novos, a Sociologia da Química e Filosofia da Educação Química, como necessários para fazer frente aos desafios de integrar uma dimensão crítica e emancipatória à formação Química e uma agenda renovada para a Educação Química inspirada por sua inscrição filosófica.
DECODING THE UMOD GENE: IMPLICATIONS FOR CHRONIC KIDNEY DISEASE THROUGH GENETIC MECHANISMS, DIAGNOSTICS, AND THERAPEUTIC INNOVATIONS
Authors: Tashkenbayeva Eleonora , Esankulov Mukhammad
Published: February 2025

This review examines recent advances in the study of UMOD genetic variations, their functional consequences, and their impact on CKD pathogenesis. It also discusses the potential clinical applications of UMOD as a predictive biomarker for early CKD detection, risk stratification, and targeted interventions. The development of transcriptomic, proteomic, and metabolomic approaches allows for a more comprehensive study of UMOD function and its interactions with other genetic and metabolic pathways. Chronic kidney disease (CKD) is a growing global health concern, affecting millions of people worldwide. Genetic factors play a crucial role in the etiology and progression of CKD, influencing susceptibility, disease severity, and treatment response. Among these factors, the UMOD gene, which encodes the glycoprotein uromodulin, is recognized as a key regulator of kidney function, tubular integrity, and disease susceptibility. UMOD polymorphisms affect kidney function by altering sodium transport, modulating immune responses, and regulating oxidative stress, thereby contributing to hypertension, nephron damage, and CKD progression.
Recent GWAS (genome-wide association studies) have confirmed the association between UMOD polymorphisms and an increased risk of CKD and its related complications. Additionally, a significant correlation has been identified between UMOD and hyperuricemia, as uromodulin plays a crucial role in uric acid transport and excretion. Conclusion: Personalized medicine based on UMOD genotyping opens new opportunities for individualized risk assessment, tailored pharmacotherapy, and lifestyle modifications to slow CKD progression. Additionally, promising therapeutic strategies are being developed, including pharmacological modulation of UMOD expression and gene therapy.The integration of genetic knowledge with clinical applications highlights the significance of UMOD in CKD pathogenesis and positions it as a promising target for precision nephrology, potentially improving clinical outcomes and optimizing patient management strategies.
LAPORAN INTERVENSI PENYULUHAN TERKAIT SARAPAN SEHAT MENURUT ISI PIRINGKU PADA SISWA/I DI SMPN 1 KEMIRI KECAMATAN KEMIRI, KABUPATEN TANGERANG, PROVINSI BANTEN
Authors: Nur Isnaeni Evry K  , Amirah Yusnidar  , Shania Vanessa Manalu  , Alya Nurul Husna  , Angela Ramanda Putri  , Dhita Ayu Kuntari Dewie
Published: February 2025

Sarapan merupakan salah satu faktor utama dalam mendukung kesehatan dan prestasi akademik siswa. Banyak siswa SMP yang melewatkan sarapan karena berbagai alasan, seperti keterbatasan waktu, kurangnya kebiasaan, serta kurangnya pemahaman mengenai pentingnya sarapan sehat. Padahal, sarapan yang seimbang dengan kandungan karbohidrat, protein, vitamin, dan mineral dapat meningkatkan daya ingat, konsentrasi, serta stamina siswa dalam mengikuti pembelajaran. Oleh karena itu, dilakukan penyuluhan mengenai pentingnya sarapan sehat berdasarkan Isi Piringku kepada siswa SMPN 1 Kemiri, Kabupaten Tangerang. Tujuan: Meningkatkan pemahaman siswa mengenai manfaat sarapan sehat, dampak negatif melewatkan sarapan, serta contoh menu sarapan bergizi sesuai panduan Isi Piringku dari Kementerian Kesehatan RI tahun 2018. Metode: Kegiatan penyuluhan ini menggunakan metode one-group pretest-posttest design dengan pendekatan edukatif melalui PowerPoint, poster, video edukasi, serta diskusi interaktif. Responden penelitian berjumlah 32 siswa SMPN 1 Kemiri yang dipilih melalui teknik convenience sampling. Evaluasi dilakukan dengan pre-test dan post-test sebelum dan setelah intervensi, kemudian data dianalisis menggunakan uji Wilcoxon dengan software SPSS. Hasil: Hasil pre-test menunjukkan nilai rata-rata pemahaman siswa sebesar 80.00, sedangkan setelah dilakukan penyuluhan, nilai rata-rata post-test meningkat menjadi 87.19. Uji Wilcoxon menunjukkan p-value <0.001, yang berarti terdapat peningkatan pemahaman yang signifikan setelah penyuluhan dilakukan. Kesimpulan: Penyuluhan mengenai sarapan sehat berdasarkan konsep Isi Piringku terbukti efektif dalam meningkatkan pemahaman siswa tentang pentingnya sarapan. Namun, masih diperlukan upaya lanjutan, seperti monitoring kebiasaan sarapan siswa, edukasi berkelanjutan melalui media digital, serta implementasi program sarapan bersama di sekolah, guna memastikan kebiasaan makan sehat dapat diterapkan secara berkelanjutan oleh siswa.
Tidsskriftet Eyr som julegave fra Cappelen Damm
Authors: Nylenna Magne , Larsen Øivind
Published: February 2025

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CONSTRUÇÃO OFF-SITE NA ARQUITETURA HOSPITALAR: UM ESTUDO DE CASO SOBRE A QUALIDADE DA CONSTRUÇÃO VOLUMÉTRICA MODULAR
Authors: Beltramini Eduardo Martins Pereira , Meirelles Célia Regina Moretti
Published: February 2025

This article is part of the author's master's thesis and emphasizes the techniques of Modular Volumetric Construction applied in hospitals, through a case study. The relevance of the technique applied to hospitals occurred with the advent of the pandemic, in 2020, this quick assembly technique, already widespread and consolidated in the residential and service market (hotels and offices), has its attention and application focused on the hospital area in response to the immediate demand for inpatient beds. The general objective of this work is to understand the quality of the processes of the off-site modular construction system, applied in adult hospitalization units. Also as specific objectives, we can address: characterization of environments from the points of view of function, flexibility, adaptability, growth and performance; understand the current market scenario of this system in the hospital area in the country; and analyze the benefits and challenges of this technique. As methodological procedures, bibliographic research, case study recognized today, technical visit, data collection and analysis were adopted. The case study refers to an annex block for hospitalization in a hospital already built, in the city of São Paulo. The expected results of this research are: presentation and approach of the volumetric modular construction technique; understanding of some concepts of hospital architecture in adult inpatient wards; and in-depth analysis of the case study for knowledge and presentation of the technique, concepts and design.
Hubungan Antara Anemia dan Fungsi Ginjal pada Pasien dengan Penyakit Ginjal Kronis
Authors: Bila Salsha , Evra Nidya Naysa , Putri Afni Mesna , Anggraini Debie
Published: February 2025

Pendahuluan: Anemia menjadi komplikasi umum pada pasien yang menderita Penyakit Ginjal Kronis (PGK) dan memberikan dampak terhadap kualitas hidup pasien. Penurunan fungsi ginjal pada pasien PGK mengakibatkan berkurangnya produksi eritropoietin, peningkatan inflamasi sistemik, defisiensi besi, dan gangguan metabolisme yang berkontribusi pada terjadinya anemia.  Tujuan: menganalisis hubungan antara anemia dan fungsi ginjal pada pasien penyakit ginjal kronis berdasarkan data klinis dan laboratorium.
Metode: Kajian ini menggunakan metode observasional dengan pendekatan cross-sectional melibatkan pasien PGK dari berbagai tahap penyakit. Parameter yang dianalisis meliputi kadar hemoglobin, estimasi laju filtrasi glomerulus (eGFR), kadar ferritin, indeks saturasi transferrin, dan penanda inflamasi C-reactive protein (CRP). Hasil: Adanya hubungan negatif antara kadar hemoglobin dan eGFR. penurunan fungsi ginjal berbanding lurus dengan tingkat anemia yang lebih berat. Selain itu, defisiensi besi dan inflamasi ditemukan sebagai faktor penting yang memperburuk kondisi anemia. Kesimpulan : Anemia pada pasien PGK memerlukan pendekatan multidisiplin yang melibatkan deteksi dini, manajemen nutrisi, dan intervensi medis yang tepat untuk memperbaiki kualitas hidup pasien dan mengurangi risiko komplikasi lebih lanjut. Penelitian ini memberikan wawasan penting untuk meningkatkan penanganan anemia pada populasi dengan penyakit ginjal kronis.
Peran Thyroid Stimulating Hormone pada Bayi Baru Lahir
Authors: Anggraini Debie , Fharel Muhammad
Published: February 2025

Latar Belakang:Kelenjar tiroid berperan penting dalam perkembangan dan fungsi berbagai sistem organ, terutama otak, sejak masa neonatal. Fungsi tiroid yang optimal pada bayi baru lahir sangat krusial untuk mendukung pertumbuhan dan perkembangan normal. Disfungsi tiroid neonatal, seperti hipotiroid kongenital, dapat berdampak signifikan pada perkembangan neurologis dan metabolisme bayi. Oleh karena itu, pemahaman tentang fisiologi tiroid neonatal dan deteksi dini gangguan fungsi tiroid menjadi aspek penting dalam kesehatan anak. Tujuan: Kajian ini bertujuan untuk mengeksplorasi peran fisiologi kelenjar tiroid pada bayi baru lahir, mekanisme regulasi hormon tiroid, serta implikasi klinis dari gangguan fungsi tiroid neonatal. Selain itu, dibahas pula program skrining hipotiroid kongenital yang bertujuan untuk mendeteksi dini gangguan tiroid dan mengurangi dampak jangka panjang terhadap perkembangan anak. Metode: Artikel ini merupakan tinjauan literatur yang mengumpulkan dan menganalisis berbagai penelitian terkini mengenai anatomi, fisiologi, regulasi hormonal, serta gangguan tiroid pada bayi baru lahir. Sumber data diperoleh dari jurnal ilmiah, buku teks, dan pedoman kesehatan nasional dan internasional. Hasil: Kelenjar tiroid neonatal memiliki peran utama dalam mengatur metabolisme dan perkembangan otak melalui produksi hormon tiroksin (T4) dan triiodotironin (T3). Produksi hormon ini dikendalikan oleh mekanisme umpan balik yang melibatkan hipotalamus dan hipofisis. Hipotiroid kongenital merupakan gangguan metabolik yang paling umum pada bayi baru lahir dan dapat menyebabkan gangguan perkembangan jika tidak terdeteksi dan ditangani secara dini. Program Skrining Hipotiroid Kongenital (SHK) telah diimplementasikan di berbagai negara, termasuk Indonesia, untuk mengidentifikasi dan mengobati gangguan tiroid neonatal secara cepat dan efektif. Kesimpulan: Fungsi tiroid yang optimal pada bayi baru lahir sangat penting untuk mendukung perkembangan neurologis dan metabolisme. Deteksi dini gangguan tiroid melalui program skrining neonatal menjadi langkah preventif yang krusial untuk mencegah komplikasi jangka panjang. Peningkatan kesadaran tenaga medis dan orang tua terhadap pentingnya fungsi tiroid neonatal dapat berkontribusi dalam meningkatkan kesehatan anak secara keseluruhan.
Oral contraceptive use and breast cancer risk: A systematic review
Authors: Valera Karen , Aguirre Camila S. , Cornejo Anthony V. , Loor Justhyn , Cedeño Kendry E. , Borroto Eugenio R.
Published: February 2025

Introduction: Breast cancer is an oncological disease associated with the transformation of mammary cells influenced by hormones. It was necessary to review the relationship between the use of oral contraceptives and the risk of developing the disease. Objectives: To analyze the relationship between oral contraceptives and the risk of breast cancer and to identify the hormonal components involved. Methodology: Articles from 2010 to August 2024 were reviewed in Scielo and Google Scholar, including systematic and original studies in Spanish, English, and Portuguese, excluding irrelevant articles. Results and Discussion: Some studies suggested a relationship between oral contraceptives and breast cancer, especially with triphasic formulations, levonorgestrel, and in women with BRCA-1 and BRCA-2 mutations. Conclusions: The use of oral contraceptives increases the risk of breast cancer, but this risk decreases if they are discontinued at least 5 years after initiation.
Relationship between COVID-19 and Guillain-Barré syndrome: systematic review
Authors: Cedeño Luis M. , Mero Nayeli N. , Indacochea Joseph , Galarza Judith
Published: February 2025

Guillain-Barré syndrome is an acute peripheral neuropathy characterized by muscle weakness and paresthesia, which can lead to paralysis. Its association with viral infections has been widely studied. During the COVID-19 pandemic, some cases of GBS have been reported, highlighting the importance of understanding the connection between COVID-19 and GBS and its clinical impact. The objective of this systematic review is to analyze recent literature to determine whether there is a relationship regarding the clinical characteristics and possible pathogenic mechanisms of GBS associated with COVID-19. Searches were conducted in the Scielo and Google Scholar databases to identify accessible studies published between 2019 and 2024 that describe a possible relationship between COVID-19 and GBS. Studies were selected based on rigorous inclusion and exclusion criteria, and 30 articles meeting the established criteria were analyzed. The reviewed studies indicate that GBS may appear as a rare but significant complication in patients with COVID-19. While some articles suggest a possible association between COVID-19 and GBS, the exact pathogenic mechanism is not yet fully defined. Further research is needed to clarify this relationship and its clinical impact. Nonetheless, current findings highlight the importance of considering GBS in COVID-19 patients who develop neurological symptoms, as this could improve early diagnosis and the management of complications.
The use of open-source software by library users in some private universities in Ghana
Authors: Silas Adjei , Kojo Agyeman Isaac , Adetsi Patience , Owusu Agyei Franklin
Published: February 2025

Introduction: This study explores the use of open-source software (OSS) by library users at Pentecost University (PU) and Central University (CU) with a focus on the ease of use, and barriers encountered. This study adopted the Technology Acceptance Model (TAM) as its framework. Methods: A descriptive survey design was employed and targeting registered undergraduate library users at both institutions. Results: 134 PU library users (88.2%) indicated that unstable internet connectivity on campus is a significant barrier to using open-source software in the Pentecost University library. Concerning library users in Central University (CU), 120 respondents (90.2%) indicated that the lack of support and training is a significant barrier hindering the use of open-source software in the Central University library.Conclusions: The study identified a divergence in the frequency of use, with CU users engaging with open-source software daily, while PU users employed it several times a week. Both CU and PU users found open-source software easy to use and interact with, contributing to a positive user experience. User-friendliness emerged as a critical factor influencing the extent of open-source software adoption. The study identified barriers that impede the effective use of open-source software, including unreliable internet connectivity at PU and inadequate resources in support and training at CU.  Hence, the library administration should adopt strategies and regulations to address the difficulties faced when utilising Open Source Software, such as providing guidance, assistance, and instructional resources.
Counting scars. Memory, history and power surrounding the censorship of rock in Cuba
Authors: Hernández Castro Junior Alfredo
Published: February 2025

Introduction: The article examines the censorship of rock in Cuba and its impact on the collective memory of the rock community. Through an approach based on oral history and the genealogy of power, the author reconstructed testimonies of musicians and fans of the genre who suffered state repression. The censorship, which began in the 1960s, was based on a combination of political paranoia, machismo and excessive revolutionary idealism. Despite the state's partial recognition of rock in recent years, episodes of repression continue to be minimized or denied in official discourse.Development: The analysis focused on the construction of memory and its use as a tool of resistance. Based on theorists such as Foucault, Ricoeur and Jelin, the author explored how individual and collective memories have been shaped by power. Events such as the controversy over the statue of John Lennon in Havana and the closure of Maxim Rock in 2023 were mentioned, both of which showed the use of institutional forgetting as a political strategy. In addition, the role of rock as a vehicle for denunciation was highlighted, with Cuban bands who have captured the experience of repression in their lyrics. The author also identified a phenomenon of “silence-forgetfulness”, in which some victims omit or modify their stories to avoid conflict or to preserve their livelihoods.Conclusion: The study revealed that the censorship of rock in Cuba not only affected individuals, but also shaped a struggle of memory and collective resistance. Despite state attempts to rewrite history, the rock community has used various platforms, from music to social networks, to preserve and vindicate their experiences. The collective memory of censorship remains alive as a form of cultural and political resistance.
Governance and participation in Yucatán, the case of participatory budgeting in Mérida
Authors: Zapata Godoy Elías
Published: February 2025

Introduction: Participatory budgeting represented an innovative mechanism for promoting citizen participation in public management. In Mérida, Yucatán, the program “Design your City” was implemented in the period 2023-2024, with the purpose of involving citizens in budgetary decision-making. Using a governance approach, the research analyzed the effectiveness of this model and its impact on the structure of local participation.Development: The study examined the formal and informal institutional arrangements that underpinned the participatory budget. Several key actors were identified, including the City Council of Mérida, autonomous bodies and civil society. The research was based on a qualitative analysis, using semi-structured interviews and documentary review to evaluate the participatory, collaborative, administrative, financial and legal dimensions of the program. It was found that the implementation of the model depended to a large extent on the capacity for coordination between institutions and citizens.Conclusions: The results indicated that participatory budgeting in Mérida promoted citizen participation, although with challenges in transparency and accountability. While consultation mechanisms were in place, the real influence of citizens on decision-making was limited. The governance of the process reflected a complex interaction between regulations and political-administrative practices, highlighting the need to strengthen the institutionalization of participatory budgeting to ensure its long-term impact.
Influence of Organizational Culture on Employee Motivation and Discipline in the Education, Youth, and Sports Department of Karawang Regency
Authors: Heryanto Rahmat , Agus Cholik  , Ahmad Kandias Bahaweres  , Joean Himawan Fadlani Sam Aldia Plg  , Nabiyil Anzal Diaswara
Published: February 2025

This study aims to analyze the influence of organizational culture on employee motivation and discipline in the Education, Youth, and Sports Department of Karawang Regency. Organizational culture is a crucial factor that can influence employee behavior and performance in government organizations. The study uses a quantitative approach with a survey method involving 65 employees as respondents. The research results show that organizational culture has a positive and significant influence on motivation (R² = 0.68) and employee discipline (R² = 0.72). These findings indicate the importance of strengthening organizational culture to improve motivation and discipline in the public sector.
Analysis of Community and Security Forces Collaboration through Socialization of Organizational Culture in the Implementation of the PILKADA 2024 Bekasi City in Margajaya Village, South Bekasi District, Bekasi City
Authors: Hidayanti Mardiana Tri , Agus Cholik  , Salsya Nuri Wafdah Sauqi  , Alfiyani Dewi Rakadita
Published: February 2025

Regional Head Elections (Pilkada) are a crucial component in Indonesia's democratic system that directly influences regional development, including in Bekasi. This study examines how organizational culture plays a role in optimizing interactions between security officers and the community to create supportive conditions during the Pilkada. The study was conducted in Margajaya Village, South Bekasi, using qualitative descriptive methodology. Data collection was conducted through a series of in-depth interviews, direct observation, documentation, and focus group discussions (FGD). The research findings indicate several obstacles in socializing organizational culture , including lack of community knowledge and obstacles in communication. The main challenges include efforts to build trust between officers and residents, and maintaining the professional attitude of officers in the field. Several solutions proposed include community-based socialization, improving officer communication skills, using information technology, and forming a work team.
Evaluation of BI-RADS 3 Ultrasound Findings: the Frequency and Incidence of Malignant Lesions, and Tumor Size
Authors: Fejzić Hanifa , Mujagić Svjetlana , Izić Belkisa
Published: February 2025

Objective. The aim of the research was to determine the frequency of BI-RADS category 3 findings in ultrasound examinations in relation to the total number of patients, the frequency of malignant lesions, and their average size at the time of detection in BI-RADS 3 ultrasound findings.
Patients and Methods. A cross-sectional study was performed on 335 patients (aged 40-75 years) classified in BI-RADS category 3, at the Tuzla Breast Center, University Clinical Center, in the period from March 2017 to November 2020. A total of 13,760 ultrasound examinations were performed, using a Toshiba Xario 100 ultrasound machine with a 12 MHz linear probe. Patients were divided into premenopausal and postmenopausal groups, excluding patients with symptoms and those with previous breast cancer surgery. The images were stored using the Institution’s Pictures Activation and Communication System.
Results. BI-RADS category 3 findings accounted for 27% of all ultrasound examinations (N=3.715). Of these, 9.02% (N=335) underwent recommended short-term follow-up. Malignancy was identified in 1.49% of these cases (N=5), with an average tumor size of 13.6 mm at detection. The malignancy rate did not differ significantly between premeno- pausal and postmenopausal patients (P=0.412). The overall diagnostic yield for malignancy in BI-RADS 3 findings was low, but clinically significant.
Conclusion. While the malignancy rate for BI-RADS category 3 findings is low (1.49%), careful monitoring and adherence to follow-up guideline are essential to balance early detection with avoidance of unnecessary biopsies and associated costs.
Fixed-point Theorems in Metric Spaces and Its Applications for Nonlinear Equations
Authors: Jadhav Amol Suresh , Rastogi Prabha Sudhir
Published: February 2025

We provide a comprehensive review of key fixed-point theorems, including Banach's Contraction Principle Kalaiarasi and Jain (2022), Schauder's Fixed-Point Theorem Jain et al. (2021), and their generalizations Liew et al. (2015). Emphasis is placed on the conditions under which these theorems can be applied to nonlinear integral equations. Examples demonstrate the practical implementation of these theorems to guarantee the existence and uniqueness of solutions. The results highlight the interplay between the structure of metric spaces, operator properties Lu et al. (2021), and the formulation of integral equations Lusch et al. (2018), offering a robust framework for tackling nonlinear problems across diverse applications Lyu et al. (2023). This research investigates the applicability of these methods in addressing nonlinear integral equations, which are commonly found in the mathematical modeling of physical, biological, and engineering systems.
Socio-Demographic Profile of Adults with Sickle Cell Disease in Osun State, Nigeria
Authors: Alaka Anuoluwapo Abisola , Iyanda Ayobola Abolape
Published: February 2025

Background: Forty years ago, both the life expectancy and quality of life of sickle cell disease (SCD) patients were low. Pinpointing the current demographic distribution of SCD patients will help in planning for the basic medical requirements for optimum care, enable indirect assessment of the success of different programs presently in place as well as determining if past efforts have yielded expected results.
Aim: Therefore, the study is directed at investigating the socio-demography of adult SCD patients in Osun state.
Methods: The study participants consisted of 98 adults, randomly selected from different health facilities. Questionnaires (pre-tested) were administered to all participants for the collection of data on socio-demographic parameters. Both descriptive and inferential statistics were performed and statistical significance was set at P < .05.
Results: The age distribution; highest academic attainment, socioeconomic status (SES), and marital status of participants were influenced by Hb genotypes, as Chi-square showed significant relationship between genotypes and (1) age (X2 = 104.55,P = <.001); (2) marital status (X2 = 115.55, P = <.001); (3) parity (X2 = 116.97,P = <.001); (4) educational status (X2 = 110.89,P = <.001) and (5) SES (X2 = 107.40,P = <.001), with HbSS patients having more participants with low SES and low academic attainment. Moreover, fewer of HbSS attained the age range of 36-45 years [15% HbSS vs 31% HbSC vs 42% HbAA] or were in a committed relationship [26% HbSS vs 56% HbSC vs 72% HbAA] compared with those with HbAA or HbSC.
Conclusion: The study suggests that much effort is still required to increase both the quality of life and life expectancy of SCD patients.
El concepto de justicia en la era digital: Cómo las teorías clásicas de la justicia se aplican (o no) a problemas actuales como la brecha digital y el acceso a la información
Authors: Guapulema Ocampo Mariana del Carmen , Palate Silva Diana Cristina , Guerrero Lara Sandra Isabel , Carrera Medina Susana Emperatriz
Published: February 2025

En la era digital, el concepto de justicia se enfrenta a nuevos desafíos que requieren una reexaminación de las teorías clásicas de la justicia. Este artículo explora cómo las ideas fundamentales sobre la justicia, como la justicia distributiva, la justicia procedimental y la justicia restaurativa, se aplican (o no) a problemas contemporáneos como la brecha digital y el acceso a la información. La brecha digital, entendida como la desigualdad en el acceso a las tecnologías de la información, plantea interrogantes sobre la distribución equitativa de los recursos digitales. A través del lente de las teorías clásicas, se analiza si estas teorías pueden proporcionar soluciones a las disparidades tecnológicas que afectan a poblaciones marginadas, como las rurales, las de bajos ingresos o las de diferentes contextos culturales. Además, el acceso a la información, que se ha convertido en un derecho fundamental en la sociedad digital, es evaluado en términos de justicia procedimental y restaurativa, considerando cómo las plataformas digitales y las políticas gubernamentales gestionan el flujo de información, la privacidad y la transparencia. Este artículo sostiene que, aunque las teorías clásicas de la justicia ofrecen una base útil para entender los problemas digitales, no son suficientes por sí solas para abordar los retos contemporáneos. Se requiere una adaptación y expansión de estos marcos teóricos para incluir las dinámicas digitales, reconociendo la importancia de la equidad en el acceso a la tecnología y la información como elementos clave para una justicia verdaderamente inclusiva en la era digital. Además, se propone una reflexión sobre cómo las nuevas formas de desigualdad digital pueden ser abordadas mediante políticas públicas innovadoras y estrategias colaborativas entre actores privados y gubernamentales.
Evaluación multidimensional de la resiliencia comunitaria ante el impacto del Tren Maya: un modelo teórico para el desarrollo sostenible
Authors: Mex Naal Pedro Marcelo , De Jesús Chi Chan María Teresita , Cruz Doriano Sacramento , Acuña Acuña Edwin Gerardo , Martínez Luis David
Published: February 2025

Este artículo propone un modelo teórico para evaluar la resiliencia comunitaria ante el impacto del Tren Maya, una infraestructura de gran escala que atraviesa varias comunidades del sureste de México. Basado en un análisis de propuestas conceptuales y estudios previos sobre resiliencia y reducción de riesgos, el modelo integra seis dimensiones clave: comprensión del proyecto, fortalecimiento de la gobernanza, reducción de la vulnerabilidad, regulación emocional, eficacia colectiva y capital social y cultural. Cada dimensión incluye indicadores específicos que abordan los aspectos económicos, sociales, ambientales y culturales más relevantes derivados del Tren Maya. El modelo es adaptable a las particularidades de cada comunidad afectada, convirtiéndolo en una herramienta versátil para evaluar tanto efectos inmediatos como a largo plazo. Entre los principales hallazgos, se destaca la necesidad de una gobernanza inclusiva, la gestión sostenible de los recursos y el fortalecimiento de la cohesión social y la identidad cultural en contextos de cambios significativos. También subraya la relevancia de la regulación emocional y la eficacia colectiva para que las comunidades puedan enfrentar y adaptarse a los desafíos generados por el proyecto. El estudio concluye que este enfoque multidimensional permite una evaluación integral de la resiliencia comunitaria, sentando bases para el diseño de políticas públicas y estrategias de mitigación que promuevan un desarrollo más equitativo y sostenible en las zonas afectadas. Además, el modelo tiene potencial para aplicarse en otros contextos donde se desarrollen grandes proyectos de infraestructura, ofreciendo una guía efectiva para reducir riesgos y fortalecer la resiliencia comunitaria.