bluuebunny/crossref_metadata_2025 huggingface dataset:
The Spiritual Coping Model of Patients with Chronic Back Pain According to Mood/Anxiety Symptoms Mediating by Emotional Schemas
Authors:   Department of Psychology, Birjand Branch, Islamic Azad University, Birjand, Iran., Ebrahimbai Salami Ali Akbar , Shahabizadeh Fatemeh ,   Department of Psychology, Birjand Branch, Islamic Azad University, Birjand, Iran., Ahi Qasim ,   Department of Psychology, Birjand Branch, Islamic Azad University, Birjand, Iran., Jarhiri Fariz Jalil ,   Department of Basic Sciences, Birjand Branch, Islamic Azad University, Birjand, Iran.
Published: December 2023

Background and Objectives: Spiritual coping strategies of patients are influenced by their mood/anxiety symptoms and emotional schemas. Therefore, the present study aimed to develop a conceptual model of spiritual coping in patients with chronic back pain, considering the role of mood/anxiety symptoms and emotional schemas. Methods: The research method was descriptive correlational. The statistical population included all women and men 25 to 55 years old with chronic back pain referring to the orthopedic and neurology clinics of Torbat Heydarieh City, Iran, in 2021-2022, of whom 400 people were selected considering the inclusion criteria using the convenience method. The tools used were the mood and anxiety symptoms questionnaire (MASQ-D30), a brief version of the Leahy emotional schema scale II-(LESS II), and the religious coping scale. The data were analyzed by structural equation modeling by SPSS software, version 24 and LISREL software, version 8.8. Results: The fitted model showed a direct relationship between mood/anxiety symptoms and emotional schemas (β=0.740), an inverse relationship between mood/anxiety symptoms and spiritual coping (β=-0.480) at the significant level of 0.05, and an indirect relationship between mood/anxiety symptoms and spiritual coping through emotional schemas (β=-0.488), which was significant at the 0.05 level. Conclusion: The results of the study supported the mediating role of emotional schemas in the relationship between mood/anxiety symptoms and spiritual coping strategies of patients with chronic back pain. Therefore, developing therapeutic interventions to reduce emotional schemas and improve spiritual coping strategies along with medical treatments is useful in adapting and improving chronic pain sufferers
Factors that interfere with the estimation of bat richness in Atlantic Forest, southeastern Brazil
Authors: Costa Luciana Moraes , Luz Júlia Lins , Tabosa Lorena de Oliveira , Bergallo Helena Godoy , Esbérard Carlos Eduardo Lustosa
Published: December 2023

Capture success of bats can be affected not only by local bat density, but also by several methodological aspects. Many factors interfere with the sampling completeness and capture success of bats. Considering the variety of sampling methods used for investigating, the objective of the present study is to analyze different factors that interfere with sampling completeness and species richness estimates of bats. To carry out the present study, we used data from the State of Rio de Janeiro from inventories carried out from 1989 to 2013 by the Laboratory of Bat Diversity and data from the literature until 2023. We analyzed the following parameters: number of sampling nights, period of nocturnal sampling, number of sites where the mist nets were opened, sampling in diurnal roosts, and moon phase. We observed that the localities with more than 30 species recorded had huge sampling efforts. For studies based on a small capture effort, the active search for roosts during the day increases the probability of recording species found mainly in high sampling effort studies. The most complete inventories are those with a sampling effort of at least 24 nights, including sampling in different habitats, such as trails, water bodies, and close to fruiting plants, as well those including search for day roosts and with fieldwork not restricted to a specific moon phase. Mist nets should be set up not only on trails and close to fruiting trees, but also over water bodies to increase the probability of recording insectivorous species.
Study Of High Performance Concrete Using Local Materials (Fly Ash Of Pltu Labuhan Angin, Mount Sinabung Volcanic Ash And Silica Sand) On The Mechanical Properties Of Concrete
Authors: Tobing Daslin , Tarigan Johannes , Johannes Tarigan  , Nursyamsi
Published: December 2023

Currently in Indonesia a lot of construction work and concrete is one that is widely used. In the development of concrete construction technology, especially in Indonesia, it is necessary to have concrete capable of carrying high loads using available materials. The development of high quality concrete has 3 levels, namely High Strength Concrete (HSC), High Performance Concrete (HPC) and Ultra High Performance Concrete (UHPC). Against the background of future needs, in this study experiments were carried out in a concrete laboratory to obtain high performance concrete mixes with local materials. At the experimental stage, testing of tools and materials, concrete mix, casting, slump test, manufacture of specimens, maintenance, checking of unit weight, compressive strength test, split tensile strength and modulus of elasticity was carried out. In that study there were 11 variations. Furthermore, the test results were analyzed by the data to draw conclusions. The results showed that the average compressive strength of concrete at 3 days of age was relatively high, namely 53.8 MPa which could be used for fast precision work. In variation 11 mixture (PCC Cement, Silica Fume, Sand Mesh 35-60, Silica Mesh 325, Water, Viscocrete Superplasticizer 8670 MN, Fly Ash 7% and Polypropylene Fiber 0.2%) tested for 28 days, the compressive strength reached 87.5 MPa, so it can be said as HPC concrete. In this study it was concluded that the use of local materials, Sinabung Volcanic Ash waste and fly ash can improve the quality of concrete and can also reduce environmental pollution.
Analytic solution of a circular plate whose boundary is elastic fixed on elastic foundation
Authors: Kim Song Bong , Kim Jong kum
Published: December 2023

On this paper an analysis of a circular plate whose boundary is elastic fixed on an elastic foundation is presented. First, we set up a schema, establish a mathematic model on it. The model becomes a boundary value problem of partial differential equation.  By solving the problem, deflections and internal forces in the circular plate are calculated concretely.
ESTABLISHMENT OF KNOWLEDGE ECONOMY IN CONDITIONS OF POST-WAR RECONSTRUCTION
Authors:   Academy of the State Penitentiary Service, Chernihiv, Ukraine, Nazarko S. O.
Published: December 2023

The article is devoted to the study of theoretical and practical aspects of the formation and development of the knowledge economy. A model of the knowledge economy is proposed, which describes an economic system where knowledge is a key resource and determines the efficiency of economic processes. It is noted that an important condition for the competitiveness of economic entities is the ability to generate, implement and use innovations, and the effectiveness of the innovative activity of the company is mainly influenced by factors related to scientific and technical works. The effectiveness of the use of the intellectual capital of Ukraine as a factor in the transformation of the national economy into a knowledge economy is considered. Issues related to modern aspects of intellectual emigration and reduction of scientific research and development in Ukraine are formulated. The peculiarities of the formation and development of the knowledge economy have been determined. Factors of knowledge management and methods of acquiring knowledge in new economic conditions are studied. The main obstacles to the development of the knowledge economy in Ukraine are indicated. The distribution of the total amount of financing of the scientific sector was analyzed and directions of reforms in the field of financing of scientific research in Ukraine were proposed. Recommendations for the reconstruction of a powerful scientific sector, which would bring maximum benefit to the future post-war economy, were formulated. Key words: knowledge economy, innovations, intellectual property, intellectual emigration, globalization, human capital, information technologies.
Mechanical Properties of Giomer After Immersion in Carbonated Drinks
Authors: Kovianti Cindy , Tjandrawinata Rosalina , Eddy Eddy
Published: December 2023

Introduction: Giomer is a resin-based restorative material consisting of prereacted glass ionomer (PRG) filler which can release fluoride. Carbonated beverages, popular beverages which contain acids that rich in H+ ions, can diffuse into the resin-based restoration and cause high solubility. Objective: To analyze the effect of immersion in carbonated drinks on water absorption and diametral tensile strength of giomer. Methods: Giomer was packed into a stainless-steel mold to obtain sample with diameter of 6.0±0.03mm and height of 3.0±0.09mm. The samples were divided into 2 groups for water absorption test and 3 groups for diametrical tensile strength test. Ten samples of giomer were soaked in artificial saliva for 4 days as a control group, 10 giomer samples were immersed in carbonated drinks for 6 hours, then replaced with artificial saliva for 18 hours and repeated for 4 days as a treatment group, and 10 samples of giomer were used as immediate group for direct diametral tensile strength test. Samples were incubated at 37°C. Results: Mann-Whitney test showed no significant difference (p>0.05) in giomer absorption between the control group (0.99±0.54%) and the treatment group (2.37±2.62%). One Way ANOVA test showed significant difference (p<0.05) in giomer diametral tensile strength among the immediate group (29.6±3.7MPa), the control group (51.1±3.9MPa) and the treatment group (44.8±5.3MPa). Conclusion: Immersion in carbonated beverages did not show significant difference with artificial saliva for the water absorption ability of giomer. However, the diametral tensile strength of giomer decreased after immersion in carbonated beverages for 24 hours.
Simultaneous Esthetic Crown Lengthening and Frenotomy Procedure for Smile Rejuvenation
Authors: Wijaksana I Komang Evan , Pinatih Made Talitha Suryaningsih , Krismariono Agung
Published: December 2023

Introduction: Gingival tissue plays an important role in smile aesthetics, especially in the anterior maxillary region. A gummy smile (GS) is a gingival condition that appears excessive when the patient smiles. The prevalence of gummy smile in individuals aged from 20 to 30 is 10% of population. It is more common in women and can cause aesthetic problems. Gummy smile aetiology is multifactorial. This case report discusses gummy smile case caused by altered passive eruption (APE) and associated with the presence of aberrant frenum. Case Report: A 19-year-old female patient with chief complaints of the excessive gingival display. The diagnosis of the case was confirmed by clinically healthy gingiva in an intact periodontium with gummy smile due to the presence of altered passive eruption type I-B accompanied by an aberrant frenum. The final surgical plan was aesthetic crown lengthening (CL) with flap surgery and osteotomy simultaneous with a frenotomy. Conclusion: The aesthetic crown lengthening surgery and frenotomy can be performed simultaneously to correct the gummy condition and improve the patient’s smile profile. Appropriate examination, diagnosis, and treatment planning help achieve optimal patient outcomes.
Dental Materials and Bisphenol-A Exposures
Authors: Hatta Ridhayani , Pratama Mohamad Arif Budiman Putra , Asencio Ílida Ortega
Published: December 2023

The utility of dental materials to posing oral diseases have impact in the risk of Bisphenol A (BPA) exposure which can be harmful to human organs. BPA used in dentistry is related to the production of polycarbonate plastics and epoxy resins. For instance, composite filling materials and dental sealant are containing BPA that can promote risk to endocrine-disrupting, estrogenic effect, and renal exposure. The current study is reviewing the BPA exposures of dental materials and it impact risk to the systemic health. This systematic review critically evaluates, and the information gathered form several literatures. The source of these articles was Pub Med and Web of Science, search done with the following terms: BPA of dental materials, BPA exposure, BPA and health risks, BPA, and oral health. BPA exposure found in oral mucosa and saliva after the application of BPA-containing dental materials. BPA derivatives used in dental products have not been evaluated for the endocrine disruptor, estrogenicity. BPA exposures can be absorbed through the oral mucosa and may lead to internal exposures the absorption of BPA from the gastrointestinal tract. Manufacturers should be required to report complete information on the chemical composition of dental materials and strict precaution application techniques must be considered by the practitioner.
Impacted Lower Third Molar Profile at Dental Hospital of Padjadjaran University
Authors: Akbar Muhammad Fauzi , Hadikrishna Indra , Riawan Lucky , Lita Yurika Ambar
Published: December 2023

Introduction: Impacted teeth are teeth that erupt incompletely in the normal eruption period. This situation can be caused by hard or soft tissue obstructions or a lack of arch jaw. Objectives: This study aimed to determine the impacted lower third molar teeth profile by age, sex, class, angulation, treatment, and anesthesia at RSGM UNPAD in 2017-2019. Methods: The study was conducted from February 8, 2020, to March 8, 2020. The study represents the impacted lower third molar teeth profile of patients referred to Outpatient Installation, Central Surgical Installation, and the Radiology Installation. Classification of tooth impaction was based on Pell & Gregory and Winter classifications using ImageJ application, while Intraclass Correlation Coefficient (ICC) was used to confirm data validity. Results: There were 146 impacted dental cases, with a total case of 62 (42.5%) for males and 84 (57.5%) for females. Most impacted teeth occurred in the 12-25 years age group up to 72 (49.3%). A total of 177 impacted teeth mostly occurred in 48 teeth, as many as 91 (51.4%). Impaction class Pell & Gregory class B with 110 (62.1%) cases were found the most. Based on the anterior border of ramus, class II with 164 (91.1%) cases was found the most. Horizontal (79 cases, 44.6%) became the most frequent angulation. The procedures taken were all odontectomy 177 (100%) with more use of local anesthesia 136 (93.2%) compared to general anesthesia 10 (6.8%). Conclusion: Cases of impacted lower third molar teeth at RSGM UNPAD in 2017-2019, were most common in females and mostly in the 12-25 years age group, with Pell & Gregory class IIB classification and Winter horizontal angulation classification, all procedures performed were odontectomy, majority using local anesthesia.
Characteristics of Orthodontic Appliance Users based on Demographics, Self-Perception, Psychosocial, and Oral Disorders (Study Among Undergraduate Students in West Jakarta)
Authors: Yovanka Vanessa , Kusnoto Joko , Andayani Lia Hapsari
Published: December 2023

Introduction: Awareness of malocclusion and the importance of orthodontic treatment continue to increase, in order to improve dentofacial appearance, psychosocial factors, and quality of life. Orthodontic treatment can be done using conventional fixed appliances, or removable appliances called clear aligners, that has an upsurge in demand recently. Previous studies have evaluated the advantages and disadvantages of orthodontic treatment types, yet there are still lack of findings regarding the characteristic of user. Objective: This study aims to describe the characteristics of orthodontic appliances users based on demographics, self-perception, psychosocial, and oral disorders, among undergraduate student in West Jakarta. Methods: This cross-sectional study was conducted in October until December 2022. The study population covered 7 universities located in West Jakarta. Sample consist of 201 undergraduate students taken by purposive sampling. Self-administered questionnaire, that had been validated was used to obtain sociodemographic data and factors that can affect the preference of orthodontic appliances. Results: The most common orthodontic appliances used is fixed orthodontic appliances (79.6%) that was installed by orthodontists (58.8%). Most students using orthodontic appliances were female (76.2%), aged 17-25 years (99.4%), and currently undergoing study in non-medical faculty (71.9%). Students were highly aware of their dental arrangement (90.5%). They thought that their facial and dental aesthetics (97.5%) and social interaction (66.2%) will improve after orthodontics treatment, though they were not sure about getting better career opportunities (51.7%). Conclusion: Fixed orthodontic appliances still become the main preference among undergraduate university students in West Jakarta. Awareness and dissatisfaction of their dental arrangements were substantial as well as the desire that facial and dental appearance will improved after treatment. Orthodontic treatment was considered as way to enhance social interaction social attractiveness.
Gong dan Mantra sebagai Simbol Komunikasi bagi Masyarakat Dayak Kalimantan Barat
Authors: Putra Zakarias Aria Widyatama , Olendo Yudhistira Oscar , Syam Christanto , Sagala Mastri Dihita
Published: December 2023

Modern era directs the younger generation of Dayak people in West Kalimantan towards cultural identity, especially gongs and mantras in meaning and function.. The purpose of this research is to identify the role of gongs and mantras as symbols of cultural communication. Through a qualitative method with the type of Roland Barthes semiotics, it is a way to reveal research on the role of gongs and mantras which is also accompanied by Susanne Knauth Langer's communication symbol theory. The gong as an accompaniment to the wood products and the mantra as a request imply a communication message between humans and God in the Nyobeng ritual of the Dayak Bidayuh community. The communication message implies the good side for the welfare of the Dayak community.
Perspektif Rasional Lukisan Abstrak di Era Kontemporer
Authors: Ernawan Erika , Effendi Ismet Zainal , Septiadi Abdusyukur Budiarvin
Published: December 2023

The accumulated meanings and the noisy visuals are one of the impacts of the contemporary art era on the painting movement in Indonesia. This research aims to analyze the aesthetic tradition of Nunung W.S. The abstract painting movement developed around 1960 to 1970s, since then there are not many records of female painters in Indonesia who use the abstract formalism approach. Qualitative methodology and literature study to analyze the artist's creation process, and described narratively with Feldman's art criticism approach. Nunung's work is always related to the process of interpreting nature in the space where she lives, using color, line, shape and space. Whether the artist's subconscious experience can be used as the basis for ideas in the process of creating abstract paintings is an implication for further research.
La ansiedad en árbitros profesionales de fútbol antes de ser evaluados físicamente
Authors: Marín Inca René Fabián , Bravo Navarro Wilson Hernando
Published: December 2023

Introducción. Para dirigir los partidos de fútbol profesional, es necesario que el árbitro cuente con un buen nivel de preparación física y mental, debido a que el esfuerzo que realizan es similar al de los jugadores, sin embargo, la ansiedad precompetitiva se refiere a un tipo de ansiedad de estado emocional inmediato, que puede ser modificable en el tiempo. Objetivo. El presente estudio tuvo como objetivo analizar el grado de ansiedad precompetitiva de los árbitros de fútbol antes de ser evaluados físicamente mediante el Cuestionario de Aproximación al Afrontamiento en el Deporte (ACSQ-1) para conocer la afectación de la ansiedad en los árbitros. Metodología. Se utilizó un diseño no experimental-transversal con un enfoque cuantitativo. Se tomó como muestra a 102 árbitros primera categoría, serie A y B. Para medir la ansiedad precompetitiva se aplicó el Cuestionario de Aproximación al Afrontamiento en el Deporte y los resultados de la evaluación física por la Comisión Nacional de Árbitros del Ecuador 2023. Resultados. Los resultados indicaron que la ansiedad precompetitiva incide en forma mínima en la evaluación de las pruebas físicas de los árbitros asistentes, se encontró un buen manejo de la carga emocional y que los árbitros están activos en su planificación. También se encontró que la gran mayoría de la muestra aprobó la prueba de velocidad 6 x 40 e intermitente. Conclusión. Demostrando una excelente condición física. Área de estudio general. Deporte. Área de estudio especifica. Preparación Física.
A Study of Barriers to Initial and Post E-Commerce Adoption among Small Businesses in Sri Lanka
Authors: Priyadarshani Gamage Nadeeka
Published: December 2023

Small businesses in Sri Lanka are considered the backbone of the economy, and e-commerce can be viewed as a ladder for business growth. However, Sri Lankan Small businesses are not adopting e-commerce to its full potential. This research examines potential barriers within the Technology-Organization-Environment (TOE) framework that affect the decision to adopt electronic commerce and post e-commerce adoption within small businesses in the Sri Lanka. The study employed a quantitative research approach, proportion-ate stratified random sampling procedures were used to select a sample of 453 firms in Hambantota District, Sri Lanka. Primary data were collected using a pre-designed and tested questionnaire. For analyzing the data derived from multiple regression. According to statistical analysis in this research the results indicates that, initial and post adoption by these businesses were found to be hindered by some of barriers existing within individual, technological, organizational, and environmental context including lack of knowledge and awareness of e-commerce, fear to change, lack of qualified personnel to develop and support ecom-merce, lack of popularity for online marketing and inadequate delivery networks, higher competition and indirect or hidden cost associated with e-commerce. The research findings will aid in developing more effective government policies and planning decisions to foster a more vibrant small business ecosystem in developing countries.
Synthetic Phonics: A Glimpse on its Effectiveness in Teaching Young Learners to Read in English as a Foreign Language
Authors: Agüero María Fátima del Valle , Francioni Agustina
Published: December 2023

Developing reading skills from an early age of schooling seems to be of paramount importance for acquiring proper literacy. As reading proves to be a complex skill to learn, the spotlight has been put on different approaches that teach young learners to read, especially in English-speaking countries. One of these approaches is Synthetic Phonics, which seems to be the most beneficial program in reading instruction. However, little research has been carried out in terms of its effectiveness to teach to read in English as a Foreign Language (EFL). This paper examines the benefits of implementing synthetic phonics in teaching learners of EFL to read. The main purpose of this investigation is to assess the effectiveness of this approach in teaching EFL learners to read in English, improving reading skills such as fluency and accuracy. For this purpose, 11 students attending Year 1 in a non-denominational co-ed bilingual school in the city of Hurlingham participated in this qualitative study. This group of students took part in a screening check to identify the sounds that were not being correctly decoded. Six remedial sessions were carried out in order to work on these specific sounds and students were tested again. Findings indicate that synthetic phonics was beneficial and, as a result, the students showed a significant increase in accuracy when decoding. The conclusion reached supports the implementation of this programme in EFL reading instruction.
The Effects of Physical Activity in Individuals with Autism Spectrum Disorder: A Qualitative Study
Authors: Orhan Bekir Erhan , Karaçam Aydın , Özdemir Ali Selman
Published: December 2023

This qualitative study aimed to investigate the effects of physical activity habits on the developmental progress and family dynamics of children with Autism Spectrum Disorder (ASD), as reported by family members. Through semi-structured interviews, the study explored the influence of physical activity on social skills, overall behaviours, and family functioning. The participants comprised 20 parents (11 females and 9 males) of children diagnosed with ASD, aged between 8 and 12 years, residing in Istanbul. The study revealed seven themes: "The Role of Physical Activities in Everyday Existence," "Regular Participation in Physical Activities," "The Frequency and Intensity of Physical Activities," "The Reaction of Children with ASD to Physical Activities," "The Effect of Physical Activities on General Behavior and Social Skills," "The Impact of Physical Activities on Family's Daily Life," and "The Effect of Physical Activities on Family Quality of Life." The findings emphasize the significance of physical activities for children with ASD, illustrating their potential to enhance social skills, emotional well-being, and overall quality of life. Additionally, these activities reduce family stress levels and enhance overall family functionality.In conclusion, based on these findings, physical activities play a vital role in the lives of children with ASD, potentially improving their social skills, emotional well-being, and overall quality of life. Moreover, engaging in such activities can alleviate family stress and enhance family functioning. These results underscore the importance of incorporating physical activities into the lives of children with ASD and provide valuable insights for designing effective intervention strategies to support their development and well-being.
Clinical Perspectives on the Evolution of Non-small Cell Lung Cancer Treatment With Immuno-oncology and ROS1 Tyrosine Kinase Inhibitors
Authors:   OPEN Health Scientific Communications, London, UK
Published: December 2023

The non-small cell lung cancer (NSCLC) treatment landscape has rapidly evolved over the last two decades. The addition of immuno-oncology (I-O) and targeted agents has improved treatment options for patients with non-metastatic and metastatic NSCLC; however, there remains significant unmet need. In this symposium, Jürgen Wolf, University Hospital Cologne, Germany; Tina Cascone, MD Anderson Cancer Center, Houston, Texas, USA; and Jose Luis Campo-Cañaveral de la Cruz, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain, discussed the increasingly complex NSCLC treatment landscape, and how the latest data may impact treatment selection. This symposium focused on I-O monotherapy and I-O combinations in treatment-naïve metastatic NSCLC, as well as the application of I-O in non-metastatic or resectable NSCLC in the neoadjuvant, peri-operative, and adjuvant settings. In addition, the latest data regarding treatment options for patients with targetable alterations, such as ROS1, were discussed, with a focus on next generation tyrosine kinase inhibitors (TKI), and how these may impact treatment selection in the future. The role of the surgeon as part of the multidisciplinary team was also discussed, with particular attention to assessment and definition of surgical complexity, as well as the importance of close collaboration and communication between the multidisciplinary team (MDT) and the patient, to ensure they are receiving the optimal treatment at the right time to improve outcomes.
Dancing and the Stance: Mapping a Creative Practice in African Dance-Drama
Authors: Elliott ‘Funmi Adewole
Published: December 2023

This article documents ‘Funmi Adewole Elliott's Practice as Research project into her solo performance practice which is derived from African dance-drama. Her aim is to develop the theoretical context of her practice. Using methods proposed by Robin Nelson, Linda Candy and Ernest Edmonds, her project focuses on the making of a short solo performance The Blind Side (2022). Through analysis of The Blind Side, Adewole Elliott describes how she utilises conventions of African storytelling and Neotraditional Creative Dance to create the performance piece and locate its discursive context. The project opens up a space of ‘know-what’ for her practice leading her to form three lines of inquiry; the conceptual-cultural domain in African dance-drama, the physical dramaturgy of the storyteller and what physical dramaturgy can offer Neotraditional Creative Dance practice.
Efficacy of dose-dense versus standard neoadjuvant chemotherapy regimensin luminal HER2-negative breast cancer: Interim results of single-centre study
Authors: Kovalenko E. I. , Zhulikov Ya. A. , Artamonova E. V. , Khoroshilov M. V. , Petrovskiy A. V. , Denchik D. A. , Vorotnikov I. K.
Published: December 2023

Introduction. The efficacy of dose-dense AC in adjuvant chemotherapy of luminal breast cancer (ER+ BC) compared with the standard dosing regimen followed by switching to taxanes has been proven in numerous clinical trials and in a large meta-analysis of the EBCTCG group. However, no study about efficiency of this regimen in neoadjuvant setting has been published.

The aim of the study. To assess the effectiveness of dose-dense regimens of neoadjuvant chemotherapy (NAC) of ER + HER2-BC (4 AC once every 2 weeks (dose dense, ddAC), then 4 courses of Docetaxel once every 3 weeks or 12 weekly injections of Paclitaxel [4D/12P]) and their comparison with the standard ones (AC once every 3 weeks [ACq3w], hereinafter 4D/12P). Primary end points are complete response rate (pCR) and RCB0–I.

Methods. This retrospective study included patients with resectable or locally advanced luminal HER2-negative breast cancer who received NAC from Janu 2017 to Aug 2022. Statistical hypothesis – the dose-dense regimen AC increases the frequency of RCB0–I from 22 to 32% compared to the standard dosing regimen with subsequent switching to taxanes, with a study power of 80%, ά = 0.05, 138 patients should be included in the study. A total of 315 patients were included in the study, of which 147 and 168 patients received dose-dense (ddAC) and standard chemotherapy (ACq3w), respectively. After propensity matching analysis 138 patients in each group were included in the final analysis.

Results. The pCR rate was 18.84% in the ddAC group versus 14.49% in the AC q3w group, the differences were not statistically significant (p = 0.379). The frequency of RCB0–I was higher in the ddAC – group 33.33% versus 21.74% in the AC q3w (p = 0.040). According to the subgroup analysis, rate of RCB0–I was significantly higher in patients younger 50 years, cN0, with the expression of progesterone receptors in ≥ 20%.

Conclusions. This is the first study to compare the efficacy of a ddAC NAC with a standard regimen for ER + HER2-BC. NAC with ddAC is associated with an increase in RCB0–I rate.
Chemotherapy with inclusion of doxorubicin, ifosfamide for common malignant glomus tumor of soft tissues of forearm (clinical case and literature review)
Authors: Savchina V. V. , Ratova E. I. , Bolotina L. V. , Karagodina Yu. B. , Fedenko A. A.
Published: December 2023

Malignant glomus tumor is an extremely rare, aggressive neoplasm, which is contain from modified glomus body’s cells. The correct morphological diagnosis is difficult, and requires careful differential diagnosis between neuroendocrine tumors, pericytic tumors, smooth muscle neoplasms. The literature describes only sporadic clinical observations, a series of cases and the results of a small number of retrospective studies. Due to the rarity of nosology, the optimal treatment strategy for this disease has not been developed. Most cases, surgical treatment is used in a locally common process. Cases of metastasis of a malignant glomus tumor are extremely rare. There is no consensus on the tactics of systemic treatment to date. In this article, we present a clinical case of achieving stabilization of the tumor process after 5 courses of chemotherapy with doxorubicin, ifosfamide in a 49-year-old patient with a malignant glomus tumor of the soft tissues of the left forearm with metastatic lesion of the tissues of the anterior chest wall on the left with spread to the left small pectoral muscle, 3rd rib and pleural cavity, with metastatic lesion lung parenchyma.
Cow’s milk protein allergy as a model of food allergy in children with inherited epidermolysis bullosa
Authors: Galimova А. А.
Published: December 2023

Inherited epidermolysis bullosa includes a spectrum of rare genodermatoses characterized by dysfunction of the skin barrier, high permeability, and therefore high risks of sensitization to the most common allergens.

The aim. To assess the prevalence of food allergies and immunological features of allergy to cow’s milk proteins among a large cohort of children with inherited epidermolysis bullosa.

Materials and methods. He study was conducted with the participation of a small cohort of children of different age groups suffering from congenital epidermolysis bullosa. Children were necessarily consulted by an allergist and a nutritionist, a detailed anamnesis was collected, specific IgE to milk and its fractions were determined using ImmunoСАР.

Results. A total of 173 children with a diagnosis of inherited epidermolysis bullosa were included in the study. Allergy to cow’s milk proteins was detected in 11.1% of children with a simple form of the disease and in 16.8% of children with dystrophic form. In the group of children with dystrophic epidermolysis bullosa, an IgE-mediated form of food allergy with a later onset was characteristic.

Conclusion. A high frequency of allergy to cow’s milk proteins in patients with inherited epidermolysis bullosa has been shown. Food allergy can affect the overall picture of the disease, and it must be diagnosed and taken into account in this category of patients, taking into account the immunopathogenesis underlying the disease, as well as the features of the skin and mucous barrier.
Assessment of the body composition of basketball players by anthropometry and bioimpedancemetry methods – comparison of the results of calculated and two hardware methods
Authors: Vybornaya К. V. , Semenov М. М. , Radzhabkadiev R. M. , Krikun E. N. , Klochkova S. V. , Nikityuk D. B.
Published: December 2023

Standardization of methods for assessing body composition is an extremely relevant topic, especially when analyzing the long-term training of athletes. Evaluation of the results of measuring body composition using the method of classical anthropometry in comparison with the hardware method of bioimpedanceometry is relevant, because Measurement results from these techniques often vary, and it is important for practitioners and trainers to be aware of these differences.

The aim of the study was to ompare the results of assessing the body composition of basketball players obtained using the calculation and two hardware methods.

Materials and methods. The survey involved 25 students-basketball players (age 20.3±1.7 years). Body composition was assessed by three methods: calculation – according to the formulas of J. Mateyk, hardware – using the body composition analyzer ABC‑01 (LLC STC «MEDASS», Russia), hardware – using the basic multi-frequency portable body composition analyzer ACCUNIQ BC310 (SELVAS Healthcare Inc., Daejeon, South Korea). Statistica software was used for statistical calculations and plotting. The significance of differences between independent groups was determined using the nonparametric Mann – Whitney test (U-test). Distribution normality was assessed using the Shapiro – Wilk test. The nonparametric Wilcoxon test was used to compare dependent samples. Correlation analysis – according to Bland – Altman.

Results and discussion. The calculation method based on anthropometry gives significantly greater results in terms of skeletal muscle mass; in terms of basal metabolism, ACCUNIQ gives the highest values, Medass – the smallest, anthropometry method – the average between the results obtained by two hardware methods. Correlation analysis showed that when determining lean body mass, the closest results are obtained when measured using two analyzers MEDAS and ACCUNIQ (r=0.938, p<0.05 5); ANTRA and ACCUNIQ give a lower correlation (r=0.819, p<0.05), the lowest correlation is shown between the ANTRA method and MEDASS (r=0.715, p<0.05). When determining body fat mass, the methods give the least correlations than when determining lean body mass: the closest results are obtained when measured using two analyzers – MEDASS and ACCUNIQ (r=0.677; p<0.05)), ANTRA and ACCUNIQ give a lower correlation (r=0.598; p<0.05) (moreover, the correlation is not significant).

Conclusion. Determination of the body composition of athletes is possible by any of the methods (caliperometry, bioimpedancemetry), given that the same method will be used for dynamic studies.
Antibacterial, probiotic and immunomodulatory properties of L. acidophilus La‑14
Authors: Orlova S. V. , Nikitina Е. А. , Popadyuk V. I. , Kuznetsova N. V. , Kirichenko I. M.
Published: December 2023

Many scientific studies show the preventive and therapeutic effects of probiotics in various diseases. The L. acidophilus La‑14 strain has proven antibacterial, probiotic and immunomodulatory effectiveness, has a long history of use and does not cause the development of antibiotic resistance. Further research is needed to determine the optimal dose and duration of probiotic intake.
Implementasi dan Unjuk Kerja Jaringan Wireless VoIP Multi Nodes di Politeknik Negeri Banyuwangi
Authors: Herman Yuliandoko  , Junaedi Adi Prasetyo
Published: December 2023

Voice over Internet Protocol (VoIP) merupakan teknologi komunikasi yang sangat berkembang di era saat ini, khususnya karena adanya perkembangan teknologi pengiriman data. Jika sebelumnya pengguna VoIP harus menggunakan sebuah desktop dan terhubung dengan jaringan kabel, saat ini hal tersebut sudah disederhanakan dengan cukup menggunakan sebuah smartphone yang terhubung dengan jaringan wireless. Dalam implementasi jaringan wireless, pastinya akan ada beberapa access point /node yang terhubung disana dan pastinya kualitas komunikasi (QoS) akan berbeda – beda pada setiap nodes. Pada penelitian ini, Kami menggunakan elastix versi 5.0 sebagai server dan tiga buah nodes access point yang dimana nantinya dilakukan percobaan untuk mengetahui bagaimana kualitas komunikasi jika antar pengguna dan server VoIP berada di berbeda nodes. Penelitian ini diharapkan bermanfaat untuk perkembangan teknologi VoIP khususnya jika diimplementasikan pada jaringan wireless yang terdiri dari beberapa nodes.
Princípios da iniciação científica em sequencia didática de Ecologia: um estudo de caso com estudantes de graduação em Ciências Biológicas
Authors: De Deus Bueno Krawczyk Ana Carolina , Ribeiro Marcos Otávio , Krupek Rogério Antonio , Wierzbicki Beatriz , Costa Luana
Published: December 2023

Ciência é uma atividade que tem como proposta buscar de forma consistente e pragmática a elaboração de teses fundamentadas e explicativas sobre diversos mecanismos da natureza/sociedade. Para que a ciência seja aplicada e depois compreendida, é necessário lançar mão de diversas ferramentas que auxiliam nesse processo. Uma dessas ferramentas é a criação de metodologias ativas que podem ser mediadores e facilitadores no processo ensino-aprendizagem. Dito isso, o presente estudo teve como objetivo e proposta avaliar o grau de compreensão e entendimento de um grupo de alunos do curso de licenciatura em Ciências Biológicas dentro da temática conceitual em Ecologia. Para tal, foram selecionados 14 alunos,  inicialmente inseridos em aulas com abordagens expositivas e dialogadas sobre o tema “Interações Ecológicas”. Após a finalização das aulas, aplicou-se um questionário online elaborado com cinco questões de múltipla escolha que versavam sobre o tema trabalhado durante as aulas. Subsequentemente, foi proposto aos estudantes o desenvolvimento de um experimento replicando possíveis interações ecológicas, objetivando observar na prática os eventos de competição e predação. Após a realização do experimento e observação dos alunos, foi aplicado o mesmo questionário utilizado anteriormente ao início do experimento. Nossos resultados apontaram que houve aumento de acertos no questionário após a realização do experimento, sendo que em termos gerais os acertos do pré-teste foram de 61,4% e no pós-teste, 67,1%. Os resultados majoritários apontados neste estudo demonstraram que, a prática em laboratório, utilizando a modalidade de delineamento experimental e abordagem problematizadora, teve papel agregador e de consolidação do conhecimento prévio estabelecido nas aulas teóricas. Esses resultados também reforçam a hipótese de que aulas interativas como metodologias ativas, associadas à contextualização observacional, podem desempenhar papel fundamental no processo ensino aprendizagem
ANALYSIS OF THE INFLUENCE OF INSTITUTIONAL OWNERSHIP, MANAGERIAL OWNERSHIP, AND OWNERSHIP STRUCTURE ON COMPANY FINANCIAL PERFORMANCE: A CASE STUDY ON MANUFACTURING COMPANIES IN INDONESIA
Authors: Effendi Syahril , Prima Argo Putra
Published: December 2023

This study aims to analyze the influence of institutional ownership, managerial ownership, and ownership structure on the financial performance of manufacturing companies in Indonesia. Regression analysis method is employed to examine the relationship between these variables and financial performance, measured through financial ratios such as Return on Assets (ROA) and Return on Equity (ROE). Data is collected from manufacturing companies listed on the Indonesia Stock Exchange during a specific period. The results of the analysis indicate a significant impact of institutional ownership on company financial performance. Higher institutional ownership tends to correlate positively with better financial performance. Conversely, the influence of managerial ownership is not as significant on financial performance. However, ownership structure proves to be a crucial factor; more diversified ownership patterns tend to be positively associated with financial performance. In the context of manufacturing companies in Indonesia, this research provides insights into the factors that can affect corporate financial performance. The implication is that increasing institutional ownership and adopting a diversified ownership structure can be beneficial strategies for companies to achieve better financial performance. Nonetheless, company management needs to consider the complex dynamics of the market and business environment while making decisions regarding ownership and financial performance
Obesity under the moonlight of c-MYC
Authors: Nevzorova Yulia A. , Cubero Francisco Javier
Published: December 2023

The moonlighting protein c-Myc is a master regulator of multiple biological processes including cell proliferation, differentiation, angiogenesis, apoptosis and metabolism. It is constitutively and aberrantly expressed in more than 70% of human cancers. Overwhelming evidence suggests that c-Myc dysregulation is involved in several inflammatory, autoimmune, metabolic and other non-cancerous diseases. In this review, we addressed the role of c-Myc in obesity. Obesity is a systemic disease, accompanied by multi-organ dysfunction apart from white adipose tissue (WAT), such as the liver, the pancreas, and the intestine. c-Myc plays a big diversity of functions regulating cellular proliferation, the maturation of progenitor cells, fatty acids (FAs) metabolism, and extracellular matrix (ECM) remodeling. Moreover, c-Myc drives the expression of a wide range of metabolic genes, modulates the inflammatory response, induces insulin resistance (IR), and contributes to the regulation of intestinal dysbiosis. Altogether, c-Myc is an interesting diagnostic tool and/or therapeutic target in order to mitigate obesity and its consequences.
GC–MS profiling of Bacillus spp. metabolites with an in vitro biological activity assessment and computational analysis of their impact on epithelial glioblastoma cancer genes
Authors: Naveed Muhammad , Ishfaq Huda , Rehman Shafique Ur , Javed Aneela , Waseem Muhammad , Makhdoom Syeda Izma , Aziz Tariq , Alharbi Metab , Alshammari Abdulrahman , Alasmari Abdullah F.
Published: December 2023

Background: Bacterial metabolites play a crucial role in human health and have proven effective in treating various diseases. In this study, the 16S rRNA method and streaking were employed to isolate and molecularly identify a bacterial strain, with the goal of characterizing bioactive volatile metabolites extracted using nonpolar and polar solvents.

Methods: Gas chromatography–mass spectrometry (GC–MS) analysis was conducted to identify 29 compounds in the bacterial metabolites, including key compounds associated with Bacillus spp. The main compounds identified included 2-propanone, 4,4-ethylenedioxy-1-pentylamine, 1,2-benzenedicarboxylic acid, 1,1-butoxy-1-isobutoxy-butane, and 3,3-ethoxycarbonyl-5-hydroxytetrahydropyran-2-one.

Results: The literature indicates the diverse biological and pharmacological applications of these compounds. Different concentrations of the metabolites from Bacillus species were tested for biological activities, revealing significant inhibitory effects on anti-diabetic activity (84.66%), anti-inflammatory activity (99%), antioxidant activity (99.8%), and anti-hemolytic activity (90%). Disc diffusion method testing also demonstrated a noteworthy inhibitory effect against tested strains.

Conclusion:In silico screening revealed that 1,2-benzenedicarboxylic acid exhibited anticancer activity and promising drug-designing properties against epithelial glioblastoma cancer genes. The study highlights the potential of Bacillus spp. as a valuable target for drug research, emphasizing the significance of bacterial metabolites in the production of biological antibacterial agents.
Alginate oligosaccharide extends the service lifespan by improving the sperm metabolome and gut microbiota in an aging Duroc boars model
Authors: Zhou Yexun , Wei Zeou , Tan Jiajian , Sun Haiqing , Jiang Haidi , Gao Yang , Zhang Hongfu , Schroyen Martine
Published: December 2023

Introduction

Alginate oligosaccharide (AOS), as a natural non-toxic plant extract, has been paid more attention in recent years due to its strong antioxidant, anti-inflammatory, and even anti-cancer properties. However, the mechanism by which AOS affects animal reproductive performance is still unclear.

Methods

The purpose of this study is to use multi-omics technology to analyze the effects of AOS in extending the service lifespan of aging boars.

Results

The results showed that AOS can significantly improve the sperm motility (p < 0.05) and sperm validity rate (p < 0.001) of aging boars and significantly reduce the abnormal sperm rate (p < 0.01) by increasing the protein levels such as CatSper 8 and protein kinase A (PKA) for semen quality. At the same time, AOS significantly improved the testosterone content in the blood of boars (p < 0.01). AOS significantly improved fatty acids such as adrenic acid (p < 0.05) and antioxidants such as succinic acid (p < 0.05) in sperm metabolites, significantly reducing harmful substances such as dibutyl phthalate (p < 0.05), which has a negative effect on spermatogenesis. AOS can improve the composition of intestinal microbes, mainly increasing beneficial bacteria Enterobacter (p = 0.1262) and reducing harmful bacteria such as Streptococcus (p < 0.05), Prevotellaceae_UCG-001 (p < 0.05), and Prevotellaceae_NK3B31_group (p < 0.05). Meanwhile, short-chain fatty acids in feces such as acetic acid (p < 0.05) and butyric acid (p < 0.05) were significantly increased. Spearman correlation analysis showed that there was a close correlation among microorganisms, sperm metabolites, and sperm parameters.

Discussion

Therefore, the data indicated that AOS improved the semen quality of older boars by improving the intestinal microbiota and sperm metabolome. AOS can be used as a feed additive to solve the problem of high elimination rate in large-scale boar studs.