bluuebunny/crossref_metadata_2025 huggingface dataset:
Metal Material Processing Using Femtosecond Lasers: Theories, Principles, and Applications
Authors: He Zhicong , Lei Lixiang , Lin Shaojiang , Tian Shaoan , Tian Weilan , Yu Zaiyuan , Li Fang
Published: July 2024

Metal material processing using femtosecond lasers is a useful technique, and it has been widely employed in many applications including laser microfabrication, laser surgery, and micromachining. The basic mechanisms of metal processing using femtosecond lasers are reviewed in this paper and the characteristics and theory of laser processing are considered. In addition to well-known processes, the recent progress relating to metals processing with femtosecond lasers, including metal material drilling, metal ablation thresholds, micro/nano-surface modification, printed circuit board (PCB) micromachining, and liquid metal (LM) processing using femtosecond lasers, is described in detail. Meanwhile, the application of femtosecond laser technology in different fields is also briefly discussed. This review concludes by highlighting the current challenges and presenting a forward-looking perspective on the future of the metal laser processing field.
Casimir Effect in MEMS: Materials, Geometries, and Metrologies—A Review
Authors: Elsaka Basma , Yang Xiaohui , Kästner Philipp , Dingel Kristina , Sick Bernhard , Lehmann Peter , Buhmann Stefan Yoshi , Hillmer Hartmut
Published: July 2024

Casimir force densities, i.e., force per area, become very large if two solid material surfaces come closer together to each other than 10 nm. In most cases, the forces are attractive. In some cases, they can be repulsive depending on the solid materials and the fluid medium in between. This review provides an overview of experimental and theoretical studies that have been performed and focuses on four main aspects: (i) the combinations of different materials, (ii) the considered geometries, (iii) the applied experimental measurement methodologies and (iv) a novel self-assembly methodology based on Casimir forces. Briefly reviewed is also the influence of additional parameters such as temperature, conductivity, and surface roughness. The Casimir effect opens many application possibilities in microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS), where an overview is also provided. The knowledge generation in this fascinating field requires interdisciplinary approaches to generate synergetic effects between technological fabrication metrology, theoretical simulations, the establishment of adequate models, artificial intelligence, and machine learning. Finally, multiple applications are addressed as a research roadmap.
A Comparative Evaluation of Powder Characteristics of Recycled Material from Bronze Grinding Chips for Additive Manufacturing
Authors: Uhlmann Eckart , Polte Julian , Fasselt Janek Maria , Müller Vinzenz , Klötzer-Freese Christian , Kleba-Ehrhardt Rafael , Biegler Max , Rethmeier Michael
Published: July 2024

In the manufacturing process of ship propellers, large quantities of grinding chips are generated. These grinding chips result from the finishing of the blade surfaces after the primary casting process of the propeller. The aim of this study was to investigate and compare different preparation processes used to produce chip powders with sufficient powder quality for the additive manufacturing process of directed energy deposition. The preparation of the samples was performed through different sieving, milling and re-melting processes. For the characterization of the prepared samples, powder analysis according to relevant industry standards was carried out. It was found that the re-melting processes result in superior powder quality for additive manufacturing in terms of particle size, morphology, and flowability. For some characteristics, the powder exhibits even better properties than those of commercial powders. Furthermore, the powder properties of the milled samples demonstrate a promising potential for use in additive manufacturing.
Development of a Dezincification-Free Alloy System for the Manufacturing of Brass Instruments
Authors: Berndorf Susanne , Markelov Anatol , Guk Sergey , Mandel Marcel , Krüger Lutz , Prahl Ulrich
Published: July 2024

Conventionally used brass alloy CuZn30 shows problems with corrosion resistance in the form of dezincification when used in brass instruments. Therefore, within the scope of this investigation, a new brass alloy CuZn30 is developed in the microalloy range with corrosion-free or corrosion-inhibiting properties. First, the influence of microalloying elements on the phase composition is investigated by simulation using Thermo-Calc. On the basis of this, suitable alloying elements and contents are selected and a modified CuZn30X alloy with 0.1% phosphorus, tin, and nickel in mass fractions, respectively, is produced. The modified alloy is then investigated with regard to its mechanical and microstructural composition and its corrosion properties. The corrosion properties were examined using stress corrosion cracking tests, dezincification tests, and the recording of polarization curves. The modified alloy exhibited good cold and hot rolling properties as well as good corrosion resistance. The dezincification test confirmed the improved corrosion resistance of the modified CuZn30X alloy, which is attributed to the formation of a protective top layer due to the alloying elements.
Evolution of Aroma Profiles in Vitis vinifera L. Marselan and Merlot from Grapes to Wines and Difference between Varieties
Authors: Ge Yi-Lin , Xia Nong-Yu , Wang Ya-Chen , Zhang Hua-Lin , Yang Wei-Ming , Duan Chang-Qing , Pan Qiu-Hong
Published: July 2024

The fermentation process has a significant impact on the aromatic profile of wines, particularly in relation to the difference in fermentation matrix caused by grape varieties. This study investigates the leaching and evolution patterns of aroma compounds in Vitis vinifera L. Marselan and Merlot during an industrial-scale vinification process, including the stages of cold soak, alcohol fermentation, malolactic fermentation, and one-year bottle storage. The emphasis is on the differences between the two varieties. The results indicated that most alcohols were rapidly leached during the cold soak stage. Certain C6 alcohols, terpenes, and norisoprenoids showed faster leaching rates in ‘Marselan’, compared to ‘Merlot’. Some branched chain fatty-acid esters, such as ethyl 3-methylbutyrate, ethyl 2-methylbutyrate, and ethyl lactate, consistently increased during the fermentation and bottling stages, with faster accumulation observed in ‘Marselan’. The study combines the Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA) model based on odor activity values to elucidate the accumulation of these ethyl esters during bottle storage, compensating for the reduction in fruity aroma resulting from decreased levels of (E)-β-damascenone. The ‘Marselan’ wine exhibited a more pronounced floral aroma due to its higher level of linalool, compared to the ‘Merlot’ wine. The study unveils the distinctive variation patterns of aroma compounds from grapes to wine across grape varieties. This provides a theoretical framework for the precise regulation of wine aroma and flavor, and holds significant production value.
Thermo-Mechanical Properties and Phase-Separated Morphology of Warm-Mix Epoxy Asphalt Binders with Different Epoxy Resin Concentrations
Authors: Wu Chengwei , Yang Haocheng , Cui Xinpeng , Cai Jun , Yuan Zuanru , Zhang Junsheng , Xie Hongfeng
Published: July 2024

The performance and phase-separated microstructures of epoxy asphalt binders greatly depend on the concentration of epoxy resin or bitumen. In this paper, the effect of the epoxy resin (ER) concentration (10–90%) on the viscosity, thermo-mechanical properties, and phase-separated morphology of warm-mix epoxy asphalt binders (WEABs) was investigated using the Brookfield rotational viscometer, differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA) and laser scanning confocal microscopy (LSCM). Due to the high reactivity of epoxy resin, the viscosity of WEABs increases with time. Furthermore, the initial viscosity of WEABs decreases with the ER concentration. Depending on the ER concentration, the viscosity–time behavior of WEABs is divided into three stages: slow (10–40%), fast (50–80%), and extremely slow (90%). In the slow stage, the viscosity slightly increases with the ER concentration, while the fast stage shows an opposite trend. DSC and DMA results reveal that WEABs with 10–80% ER exhibit two glass transition temperatures (Tgs) for cured epoxy resin and bitumen. Moreover, the Tgs of epoxy resin and bitumen increase with the ER concentration. However, WEAB with 90 % ER has only one Tg. LSCM observation shows that phase separation occurs in all WEABs. For WEABs containing 10–40% ER, spherical epoxy particles act as the discontinuous phase and disperse in the continuous bitumen phase. However, in WEABs with 50–90% ER, phase inversion takes place. Contrarily, bitumen particles disperse in the continuous epoxy phase. The damping properties of WEABs with the continuous epoxy phases increase with the ER concentration, while the crosslinking density shows an opposite trend. The occurrence of phase inversion results in a sharp increase in the tensile strength of WEABs. For WEABs with the continuous epoxy phases, the elongation at break increases with the ER concentration. The toughness first increases and then decreases with the ER concentration. A maximum toughness value shows at 70% ER.
Effects of Cation Exchange in Rhodamine B Photocatalytic Degradation Using Peroxo-Titanate Nanotubes
Authors: Han Do Hyung , Park Hyunsu , Goto Tomoyo , Cho Sunghun , Seo Yeongjun , Kondo Yoshifumi , Nishida Hisataka , Sekino Tohru
Published: July 2024

Lepidocrocite-type layered sodium titanate (NaxH2−xTi2O5) is widely used in environmental remediation because of its large specific surface area, formed by anisotropic crystal growth, and its ability to store and exchange cations between layers. Additionally, peroxo-titanate nanotubes (PTNTs), which are tubular titanates with peroxy groups, exhibit visible-light absorption capabilities, rendering them suitable for photocatalytic applications under visible light irradiation. However, because of cation exchange reactions, the Na+ concentration and pH of the solution can fluctuate under aqueous conditions, affecting the photocatalytic performance of the PTNTs. Herein, we evaluated the impact of cation exchange reactions on the photocatalytic degradation of Rhodamine B (Rh B) by PTNTs at controlled Na+ ratios. The observed pH of Rh B solutions increases due to the cation exchange reaction with Na+ and H3O+, leading to the formation of zwitter-ionic Rh B molecules, eventually weakening their adsorption and photodegradation performance. Moreover, the results indicate that inhibiting the pH increase of the Rh B solution can prevent the weakening of both the adsorption and photodegradation performance of PTNTs. This study highlights the significance of regulating the sodium ion content in layered titanate materials, emphasizing their importance in optimizing these materials’ photocatalytic efficacy for environmental purification applications.
The Role of Diet and the Gut Microbiota in Reactive Aggression and Adult ADHD—An Exploratory Analysis
Authors: Jakobi Babette , Cimetti Chiara , Mulder Danique , Vlaming Priscilla , Franke Barbara , Hoogman Martine , Arias-Vasquez Alejandro
Published: July 2024

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition, of-ten persistent into adulthood and accompanied by reactive aggression. Associations of diet and the gut-microbiome with ADHD as well as emotional behaviors suggest potential clinical rele-vance of both. However, studies on diet and the gut-microbiome in human reactive aggression are lacking, and should investigate the interaction between diet and the gut-microbiome leading to behavioral changes to assess their potential clinical relevance. In this study, we investigated the interaction of diet and gut-microbiota with adult ADHD and reactive aggression in 77 adults with ADHD and 76 neurotypical individuals. We studied the relationships of ADHD and reactive ag-gression with dietary patterns, bacterial community and taxonomic differences of 16S-sequenced fecal microbiome samples, and potential mediating effects of bacterial genus abundance on signifi-cant diet-behavior associations. The key findings include: (1) An association of high-energy intake with reactive aggeression scores (pFDR = 4.01 × 10−02); (2) Significant associations of several genera with either reactive aggression or ADHD diagnosis with no overlap; and (3) No significant mediation effects of the selected genera on the association of reactive aggression with the high-energy diet. Our results suggest that diet and the microbiome are linked to reactive aggression and/or ADHD individually, and highlight the need to further study the way diet and the gut-microbiome inter-act.
Effect of Low-Dose Mulberry Fruit Extract on Postprandial Glucose and Insulin Responses: A Randomized Pilot Trial in Individuals with Type 2 Diabetes
Authors: Mela David J. , Alssema Marjan , Hiemstra Harry , Hoogenraad Anne-Roos , Kadam Tanvi
Published: July 2024

Adding mulberry fruit extract (MFE) to carbohydrate-rich meals can reduce postprandial glucose (PPG) and insulin (PPI) responses in healthy individuals. This pilot study assessed the acute postprandial effects of low doses of MFE in individuals with type 2 diabetes. In a randomized cross-over (within-subjects) design, 24 unmedicated adult males and females with type 2 diabetes (mean [SD] age 51.0 [9.3] yr, BMI 27.5 [3.9] kg/m2) consumed meals with 0 (control), 0.37, and 0.75 g of MFE added to ~50 g of available carbohydrates from rice. Primary and secondary outcomes were the PPG 2 hr positive incremental area under the curve and the corresponding PPI. Results were reported as mean differences from the control meal with 95% CI. Relative to control, 0.37 and 0.75 g of MFE reduced the mean 2 hr PPG by 8.2% (−20.8 to 6.6%) and 22.4% (−38.6 to −1.9%), respectively, and reduced PPI by 9.6% (−20.7 to 3.0%) and 17.5% (−27.9 to −5.7%). There were no indications of adverse events or gastrointestinal discomfort. MFE additions also led to dose-related reductions in glucose peak and glucose swing. At these levels, MFE appears to dose-dependently reduce acute PPG and PPI in individuals with type 2 diabetes and may be a feasible dietary approach to help attenuate glycemic exposures.
Bone Health in Premenopausal Women with Coeliac Disease: An Observational Study
Authors: Schraders Katie , Coad Jane , Kruger Marlena
Published: July 2024

Low bone mineral density (BMD) is common in adults with coeliac disease (CD), even in individuals adhering to a gluten-free diet (GFD). Women are more likely to have low BMD and have an increased risk of osteoporosis, so women with pre-existing low BMD related to CD are at an even higher risk. BMD assessed by dual X-ray absorptiometry (DXA) and bone quality assessed through quantitative ultrasound (QUS) were investigated in 31 premenopausal women with CD consuming a GFD, and 39 matched healthy controls from the Lower North Island, New Zealand. In addition, bone metabolism and nutrient status were assessed, and four-day diet diaries were used to estimate nutrient intake. No statistically significant differences were found in BMD assessed by DXA between the two groups at the hip, lumbar spine or forearm. However, the parameters measured by the QUS were significantly lower in CD participants. Dietary data indicated significantly lower intakes of energy, dietary fibre, magnesium and phosphorus in women with CD, likely as a result of a reduced intake of wholegrain foods, and suggested that both groups had inadequate intake of calcium. No significant differences were demonstrated in biochemical parameters. BMD and bone biomarkers indicated no differences between coeliac and healthy women in New Zealand. However, these findings suggest that QUS may be more sensitive for the coeliac population, due to the disease’s affect on the trabecular bone, and warrant further research.
Diet Supplemented with Special Formula Milk Powder Promotes the Growth of the Brain in Rats
Authors: Mu Ruiqi , Li Jufang , Fu Yu , Xie Qinggang , Ma Weiwei
Published: July 2024

This investigation was to study the effects of different formula components on the brain growth of rats. Fifty male SD rats were randomly divided into five groups: a basic diet group; a 20% ordinary milk powder group; a 20% special milk powder group; a 30% ordinary milk powder group; and a 30% special milk powder group by weight. LC-MS was used to detect brain lipidomics. After 28 days of feeding, compared with the basic diet group, the brain/body weights of rats in the 30% ordinary milk powder group were increased. The serum levels of 5-HIAA in the 30% ordinary milk powder group were lower than in the 20% ordinary milk powder group. Compared with the basic diet group, the expressions of DLCL, MePC, PI, and GM1 were higher in the groups with added special milk powder, while the expressions of LPE, LdMePE, SM, and MGTG were higher in the groups with added ordinary milk powder. The expression of MBP was significantly higher in the 20% ordinary group. This study found that different formula components of infant milk powder could affect brain growth in SD rats. The addition of special formula infant milk powder may have beneficial effects on rat brains by regulating brain lipid expression.
Lipoprotein Metabolism, Dyslipidemia, and Lipid-Lowering Therapy in Women: A Comprehensive Review
Authors: Zimodro Jakub Michal , Mucha Magda , Berthold Heiner K. , Gouni-Berthold Ioanna
Published: July 2024

Lipid-lowering therapy (LLT) is a cornerstone of atherosclerotic cardiovascular disease prevention. Although LLT might lead to different reductions in low-density lipoprotein cholesterol (LDL-C) levels in women and men, LLT diminishes cardiovascular risk equally effectively in both sexes. Despite similar LLT efficacy, the use of high-intensity statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors is lower in women compared to men. Women achieve the guideline-recommended LDL-C levels less often than men. Greater cholesterol burden is particularly prominent in women with familial hypercholesterolemia. In clinical practice, women and men with dyslipidemia present with different cardiovascular risk profiles and disease manifestations. The concentrations of LDL-C, lipoprotein(a), and other blood lipids differ between women and men over a lifetime. Dissimilar levels of LLT target molecules partially result from sex-specific hormonal and genetic determinants of lipoprotein metabolism. Hence, to evaluate a potential need for sex-specific LLT, this comprehensive review (i) describes the impact of sex on lipoprotein metabolism and lipid profile, (ii) highlights sex differences in cardiovascular risk among patients with dyslipidemia, (iii) presents recent, up-to-date clinical trial and real-world data on LLT efficacy and safety in women, and (iv) discusses the diverse medical needs of women and men with dyslipidemia and increased cardiovascular risk.
Biomedical Promise of Aspergillus Flavus-Biosynthesized Selenium Nanoparticles: A Green Synthesis Approach to Antiviral, Anticancer, Anti-Biofilm, and Antibacterial Applications
Authors: Mohammed Eman Jassim , Abdelaziz Ahmed E. M. , Mekky Alsayed E. , Mahmoud Nashaat N. , Sharaf Mohamed , Al-Habibi Mahmoud M. , Khairy Nehal M. , Al-Askar Abdulaziz A. , Youssef Fady Sayed , Gaber Mahmoud Ali , Saied Ebrahim , AbdElgayed Gehad , Metwally Shimaa A , Shoun Aly A.
Published: July 2024

This study utilized Aspergillus flavus to produce selenium nanoparticles (Se-NPs) in an environmentally friendly and ecologically sustainable manner, targeting several medicinal applications. These biosynthesized Se-NPs were meticulously characterized using X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscope (TEM), and UV–visible spectroscopy (UV), revealing their spherical shape and size ranging between 28 and 78 nm. We conducted further testing of Se-NPs to evaluate their potential for biological applications, including antiviral, anticancer, antibacterial, antioxidant, and antibiofilm activities. The results indicate that biosynthesized Se-NPs could be effective against various pathogens, including Salmonella typhimurium (ATCC 14028), Bacillus pumilus (ATCC 14884), Staphylococcus aureus (ATCC 6538), Clostridium sporogenes (ATCC 19404), Escherichia coli (ATCC 8739), and Bacillus subtilis (ATCC 6633). Additionally, the biosynthesized Se-NPs exhibited anticancer activity against three cell lines: pancreatic carcinoma (PANC1), cervical cancer (Hela), and colorectal adenocarcinoma (Caco-2), with IC50 values of 177, 208, and 216 μg/mL, respectively. The nanoparticles demonstrated antiviral activity against HSV-1 and HAV, achieving inhibition rates of 66.4% and 15.1%, respectively, at the maximum non-toxic concentration, while also displaying antibiofilm and antioxidant properties. In conclusion, the biosynthesized Se-NPs by A. flavus present a promising avenue for various biomedical applications with safe usage.
Where Are We Now with Oncolytic Viruses in Melanoma and Nonmelanoma Skin Malignancies?
Authors: Nassief George , Anaeme Angela , Moussa Karen , Chen David , Ansstas George
Published: July 2024

Skin cancer prognosis has greatly improved recently due to the introduction of immune checkpoint inhibitors (ICIs). However, many patients with advanced skin cancer still experience immunotherapy resistance and disease progression during ICI treatment, thus calling for novel therapeutics which address this treatment gap. Talimogene laherparepvec (T-VEC) has gained popularity in recent years as a viable treatment option for patients with skin cancer. In preclinical studies, T-VEC demonstrated both a direct anti-tumor effect in injected lesions as well as a systemic immune-mediated effect in non-injected lesions, which could pose additional benefits when combined with ICI therapy. Following promising results from the OPTiM trial, the Food and Drug Administration (FDA) approved the usage of T-VEC as a single agent in advanced melanoma. However, the MASTERKEY-265 trial demonstrated that adding T-VEC to pembrolizumab did not offer additional clinical benefit in patients with melanoma. Nevertheless, the promising efficacy of T-VEC and its approval by the FDA helped oncolytic viruses (OVs) gain wide attention in cancer therapy, and extensive research has been undertaken to evaluate the usage of OVs in other tumors such as sarcomas and breast cancers. Here, we provide a review of clinical results from 2022 to 2024 that investigate the efficacy and safety of OVs as a monotherapy or in combination with other therapies in skin malignancies. Furthermore, we delineate the current limitations in OV utilization and outline future directions to enhance clinical outcomes for patients with skin malignancies receiving OV-based therapies.
Effects of Postprandial Factors and Second Meal Intake Time on Bioequivalence Investigation of Tadalafil-Loaded Orodispersible Films in Human Volunteers
Authors: Park Su-Jun , Gil Myung-Chul , Lee Bong-Sang , Jung Minji , Lee Beom-Jin
Published: July 2024

Tadalafil (TD) has poor water solubility but is well absorbed without affecting food intake when administered orally. Owing to patient adherence and therapeutic characteristics, a TD-loaded orodispersible film (TDF) is preferable. However, the mechanistic role of dietary status on the clinical pharmacokinetic analysis of TDF in human volunteers should be investigated because the gastrointestinal environment varies periodically according to meal intervals, although commercial 20 mg TD-loaded tablets (TD-TAB, Cialis® tablet) may be taken with or without food. TDF was prepared by dispersing TD in an aqueous solution and polyethylene glycol 400 to ensure good dispersibility of the TD particles. In the fasting state, each T/R of Cmax and AUC between TD-TAB and TDF showed bioequivalence with 0.936–1.105 and 1.012–1.153, respectively, and dissolution rates in 1000 mL water containing 0.5% SLS were equivalent. In contrast, TDF was not bioequivalent to TD-TAB under the fed conditions by the Cmax T/R of 0.610–0.798. The increased dissolution rate of TDF via the micronization of drug particles and the reduced viscosity of the second meal content did not significantly affect the bioequivalence. Interestingly, an increase in second meal intake time from 4 h to 6 h resulted in the bioequivalence by the Cmax T/R of 0.851–0.998 of TD-TAB and TDF. The predictive diffusion direction model for physical digestion of TD-TAB and TDF in the stomach after the first and second meal intake was successfully simulated using computational fluid dynamics modeling, accounting for the delayed drug diffusion of TDF caused by prolonged digestion of stomach contents under postprandial conditions.
The Fathers of the Church, the Reformation, and the Failed Attempts at Union between the Tübingen Theologians and the Patriarchate of Constantinople: A Broad Perspective
Authors: Baghos Mario
Published: July 2024

The sixteenth century witnessed dramatic upheavals in Eastern and Western Europe in both the ecclesiastical and political domains. In the previous century, Constantinople had fallen to the Ottoman Turks, meaning that its Eastern Orthodox inhabitants were severed both politically and religiously from their Western Christian neighbors, who were ruled over by sovereigns that derived their spiritual authority from the Papacy. Meanwhile, the Reformation endangered the unity of the political and religious spheres of the Catholic West. As it soon became clear that the mainstream Reformers were neither united nor consistent in their ecclesiological views, one thing remained a constant: a recourse to the Fathers of the Church for the confirmation of Reformed tenets such as sola scriptura and sola fide. The use of Patristic proof texts played an important role in the attempt of the Lutherans to unite with the Orthodox, the former reading the writings of the Fathers in a very different way to the latter. This article analyzes why this attempt at union failed, with specific focus on the correspondence between the Tübingen theologians and the Patriarch of Constantinople, Jeremiah II Tranos, in their respective reading of the Augsburg Confession which represents the main Lutheran articles of faith.
Improving the Estimation of Lake Ice Thickness with High-Resolution Radar Altimetry Data
Authors: Mangilli Anna , Duguay Claude R. , Murfitt Justin , Moreau Thomas , Amraoui Samira , Mugunthan Jaya Sree , Thibaut Pierre , Donlon Craig
Published: July 2024

Lake ice thickness (LIT) is a sensitive indicator of climate change, identified as a thematic variable of Lakes as an Essential Climate Variable (ECV) by the Global Climate Observing System (GCOS). Here, we present a novel and efficient analytically based retracking approach for estimating LIT from high-resolution Ku-band (13.6 GHz) synthetic-aperture radar (SAR) altimetry data. The retracker method is based on the analytical modeling of the SAR radar echoes over ice-covered lakes that show a characteristic double-peak feature attributed to the reflection of the Ku-band radar waves at the snow–ice and ice–water interfaces. The method is applied to Sentinel-6 Unfocused SAR (UFSAR) and Fully Focused SAR (FFSAR) data, with their corresponding tailored waveform model, referred to as the SAR_LIT and FFSAR_LIT retracker, respectively. We found that LIT retrievals from Sentinel-6 high-resolution SAR data at different posting rates are fully consistent with the LIT estimations obtained from thermodynamic lake ice model simulations and from low-resolution mode (LRM) Sentinel-6 and Jason-3 data over two ice seasons during the tandem phase of the two satellites, demonstrating the continuity between LRM and SAR LIT retrievals. By comparing the Sentinel-6 SAR LIT estimates to optical/radar images, we found that the Sentinel-6 LIT measurements are fully consistent with the evolution of the lake surface conditions, accurately capturing the seasonal transitions of ice formation and melt. The uncertainty in the LIT estimates obtained with Sentinel-6 UFSAR data at 20 Hz is in the order of 5 cm, meeting the GCOS requirements for LIT measurements. This uncertainty is significantly smaller, by a factor of 2 to 3 times, than the uncertainty obtained with LRM data. The FFSAR processing at 140 Hz provides even better LIT estimates, with 20% smaller uncertainties. The LIT retracker analysis performed on data at the higher posting rate (140 Hz) shows increased performance in comparison to the 20 Hz data, especially during the melt transition period, due to the increased statistics. The LIT analysis has been performed over two representative lakes, Great Slave Lake and Baker Lake (Canada), demonstrating that the results are robust and hold for lake targets that differ in terms of size, bathymetry, snow/ice properties, and seasonal evolution of LIT. The SAR LIT retrackers presented are promising tools for monitoring the inter-annual variability and trends in LIT from current and future SAR altimetry missions.
Using Multi-Source National Forest Inventory Data for the Prediction of Tree Lists of Individual Stands for Long-Term Simulation
Authors: Siipilehto Jouni , Henttonen Helena M. , Katila Matti , Mäkinen Harri
Published: July 2024

Forest resource maps and small area estimates have been produced by combining national forest inventory (NFI) field plot data, multispectral satellite images and numerical map data. We evaluated k-nearest neighbors (k-NN) method-based predictions of forest variables for pixels in predicting tree lists of individual stands, including tree diameters at breast height and tree heights and then calculated stem volumes and tree species proportions. We compared alternative parameters (k-NN) using k of either 1 or 5 according to preliminary plot-level study and applying either measured trees (1-NN_trees) or mean stand characteristics (k-NN_stand). In the 1-NN_trees method, a tree list was generated based on the measured trees of the NFI plots, whereas in the 1-NN_stand and 5-NN_stand methods, a Weibull-based diameter distribution was recovered from the stand characteristics of the same inventory plots. In both methods, tree lists were predicted for each 16 m × 16 m pixel included in the stand compartment. Both methods performed well and resulted in 8–14% differences in the total volume compared with the field inventory of the 27 stands used for the evaluation. Moreover, the main tree species was correctly predicted for 74% of cases. The RMSE in total volume ranged from 25% (5-NN_stand) to 31% (1-NN_stand), while the smallest RMSEs in volume by tree species were 61% for broadleaves and 65% for pine and spruce using the 5-NN_stand. When comparing input data for a long-term growth simulation, the choice of the method was less influential as the effect of the error in the initial stand characteristics decreased over time during the simulation period. After 30-year simulation of the inventoried stands, the respective RMSEs were 9.4% for total volume and 39%, 50% and 59% for tree species, respectively. The satellite-based data with NFI plots were useful for predicting tree lists for pixels of a stand. However, the accuracy for operational forest management was still questionable. For a larger area’s strategic information, the accuracy is considered adequate.
Random Stepped Frequency ISAR 2D Joint Imaging and Autofocusing by Using 2D-AFCIFSBL
Authors: Wang Yiding , Li Yuanhao , Song Jiongda , Zhao Guanghui
Published: July 2024

With the increasingly complex electromagnetic environment faced by radar, random stepped frequency (RSF) has garnered widespread attention owing to its remarkable Electronic Counter-Countermeasure (ECCM) characteristic, and it has been universally applied in inverse synthetic aperture radar (ISAR) in recent years. However, if the phase error induced by the translational motion of the target in RSF ISAR is not precisely compensated, the imaging result will be defocused. To address this challenge, a novel 2D method based on sparse Bayesian learning, denoted as 2D-autofocusing complex-value inverse-free SBL (2D-AFCIFSBL), is proposed to accomplish joint ISAR imaging and autofocusing for RSF ISAR. First of all, to integrate autofocusing into the ISAR imaging process, phase error estimation is incorporated into the imaging model. Then, we increase the speed of Bayesian inference by relaxing the evidence lower bound (ELBO) to avoid matrix inversion, and we further convert the iterative process into a matrix form to improve the computational efficiency. Finally, the 2D phase error is estimated through maximum likelihood estimation (MLE) in the image reconstruction iteration. Experimental results on both simulated and measured datasets have substantiated the effectiveness and computational efficiency of the proposed 2D joint imaging and autofocusing method.
Evaluation of NOx and PN Emission in Relation to Actuator Control
Authors: Biró Norbert , Szőllősi Dániel , Kiss Péter
Published: July 2024

This study aimed to investigate the interrelationships between key harmful emission components, nitrogen oxides (NOx), and particulate numbers (PNs) in diesel engine exhaust and the control actuators of diesel engines. This research involved conducting a series of experiments under fixed parameters within an engine brake laboratory environment to elucidate these correlations. The objectives of this study were to conduct a comprehensive review of the relevant emissions technology literature and a comparative assessment of particle measurement methods based on dilution ratios and develop innovative aerosol preparation principles tailored to condensation particle measurement. Additionally, this research involved designing and implementing an aerosol preparation unit based on the newly developed principles, along with the creation of test cell control programs using the AVL PUMA Open TST editor interface and Visual Basic. Furthermore, this study was concerned with conducting evaluations of fixed-parameter engine dynamometer tests to explore the functional relationships between the emission of 10/23 nm particles, NOx emissions, common rail pressure variations, and exhaust gas recirculation levels. This study aimed to enhance the understanding of diesel engine emissions dynamics and contribute valuable insights for developing more efficient and environmentally friendly engine control strategies.
A Narrowband IoT Personal Sensor for Long-Term Heart Rate Monitoring and Atrial Fibrillation Detection
Authors: Cinotti Eliana , Centracchio Jessica , Parlato Salvatore , Andreozzi Emilio , Esposito Daniele , Muto Vincenzo , Bifulco Paolo , Riccio Michele
Published: July 2024

Long-term patient monitoring is required for detection of episodes of atrial fibrillation, one of the most widespread cardiac pathologies. Today, the most used non-invasive technique is Holter electrocardiographic (ECG) monitoring, which can often prove ineffective because of the short duration of recordings (e.g., one day). Other techniques such as photo-plethysmography are adopted by smartwatches for much longer duration monitoring, but this has the disadvantage of offering only intermittent measurements. This study proposes an Internet of Things (IoT) sensor that can provide a very long period of continuous monitoring. The sensor consists of an ECG-integrated Analog Front End (MAX30003), a microcontroller (STM32F401RE), and an IoT narrowband module (STEVAL-STMODLTE). The instantaneous heart rate is extracted from the ECG recording in real time. At intervals of two minutes, the sequence of inter-beat intervals is transmitted to an IoT cloud platform (ThingSpeak). Settled atrial fibrillation event recognition software runs on the cloud and generates alerts when it recognizes such arrhythmia. Performances of the proposed sensor were evaluated by generating analog ECG signals from a public dataset of ECG signals with atrial fibrillation episodes, the MIT-BIH Atrial Fibrillation Database, each recording lasting approximately 10 h. Software implementing the Lorentz algorithm, one of the best detectors of atrial fibrillation, was implemented on the cloud platform. The accuracy, sensitivity, and specificity in recognizing atrial fibrillation episodes of the proposed system was calculated by comparison with a cardiologist’s reference data. Across all patients, the proposed method achieved an accuracy of 0.88, a sensitivity 0.71, and a specificity 0.99. The results obtained suggest that the developed system can continuously record and transmit heart rhythms effectively and efficiently and, in addition, offers considerable performance in recognizing atrial fibrillation episodes in real time.
Accelerometer Thresholds for Estimating Physical Activity Intensity Levels in Infants: A Preliminary Study
Authors: Ghazi Mustafa A. , Zhou Judy , Havens Kathryn L. , Smith Beth A.
Published: July 2024

Lack of physical activity (PA) at a young age can result in health issues. Thus, monitoring PA is important. Wearable accelerometers are the preferred tool to monitor PA in children. Validated thresholds are used to classify activity intensity levels, e.g., sedentary, light, and moderate-to-vigorous, in ambulatory children. No previous work has developed accelerometer thresholds for infancy (pre-ambulatory children). Therefore, this work aims to develop accelerometer thresholds for PA intensity levels in pre-ambulatory infants. Infants (n = 10) were placed in a supine position and allowed free movement. Their movements were synchronously captured using video cameras and accelerometers worn on each ankle. The video data were labeled by activity intensity level (sedentary, light, and moderate-to-vigorous) in two-second epochs using observational rating (gold standard). Accelerometer thresholds were developed for acceleration and jerk using two optimization approaches. Four sets of thresholds were developed for dual (two ankles) and for single-worn (one ankle) accelerometers. Of these, for a typical use case, we recommend using acceleration-based thresholds of 1.00 m/s to distinguish sedentary and light activity and 2.60 m/s to distinguish light and moderate-to-vigorous activity. Acceleration and jerk are both suitable for measuring PA.
Temporal-Quality Ensemble Technique for Handling Image Blur in Packaging Defect Inspection
Authors: Son Guk-Jin , Jung Hee-Chul , Kim Young-Duk
Published: July 2024

Despite achieving numerous successes with surface defect inspection based on deep learning, the industry still faces challenges in conducting packaging defect inspections that include critical information such as ingredient lists. In particular, while previous achievements primarily focus on defect inspection in high-quality images, they do not consider defect inspection in low-quality images such as those containing image blur. To address this issue, we proposed a noble inference technique named temporal-quality ensemble (TQE), which combines temporal and quality weights. Temporal weighting assigns weights to input images by considering the timing in relation to the observed image. Quality weight prioritizes high-quality images to ensure the inference process emphasizes clear and reliable input images. These two weights improve both the accuracy and reliability of the inference process of low-quality images. In addition, to experimentally evaluate the general applicability of TQE, we adopt widely used convolutional neural networks (CNNs) such as ResNet-34, EfficientNet, ECAEfficientNet, GoogLeNet, and ShuffleNetV2 as the backbone network. In conclusion, considering cases where at least one low-quality image is included, TQE has an F1-score approximately 17.64% to 22.41% higher than using single CNN models and about 1.86% to 2.06% higher than an average voting ensemble.
Computer-Based Experiment for the Motion of Spring Oscillator on a Linear Air Track Using Ultrasonic Sensor
Authors: Wu Bin , Xu Yiqing , Zhou Guoquan , Fan Yan
Published: July 2024

In the present paper, an affordable innovative physical experimental equipment consisting of an upper computer, an ultrasonic sensor module, and an Arduino microcontroller has been designed. The relationship between the position of the slider fixed on two springs and time is measured by using the ultrasonic sensor module. A system for slider motion data and image acquisition is constructed by using the LabVIEW interface of Arduino UNO R3. The purpose of this experiment is to demonstrate and interpret the propagation of waves represented by harmonic motion. The spring oscillator system including a slider and two springs is measured and recorded, and the motion can be realized using curve fitting to the wave equation in Sigmaplot. The vibration periods obtained from experimental measurements and curve fitting of the wave equation are 1.130 s and 1.165 s, respectively. The experimental data are in good agreement with the theoretical model. The experimental measurement results show that the maximum kinetic energy is 0.0792 J, the maximum potential energy is 0.0795 J, and the total energy at the position of half the amplitude is 0.0791 J. The results verify the mechanical energy conservation of spring oscillator system in a short time. This self-made instrument has improved the visualization and the automation level of the corresponding experiments.
Research on Intelligent Prefabricated Reinforced Concrete Staircase Lifting Point Setting Method Considering Multidimensional Spatial Constraint Characteristics
Authors: Yang Yang , Cai Xiaodong , Yao Gang , Wang Meng , Zhou Canwei , Lei Ting , Zhang Yating
Published: July 2024

Prefabricated reinforced concrete staircases (PC staircases) are prefabricated components that are widely used in prefabricated buildings and are used in large quantities. During the production and construction of a PC staircase, the lifting point setting directly affects the construction safety, construction efficiency, and construction quality. In this paper, we analyze the quality problems and safety risks in the design, production, and construction of PC staircases under the constraints of multidimensional spatial characteristics, clarify the key technical difficulties of prefabricated staircase lifting under the multidimensional spatial and temporal constraints, and analyze the factors that should be considered in the setting of lifting points. In this paper, a prefabricated staircase lifting point setting database is established and a thin-plate spline interpolation algorithm is introduced to expand it. Based on the support vector machine algorithm, the process of optimization is carried out for the kernel function scale parameter and penalty factor, and it is concluded that for every increase of two in the number of cross-validation folds, the percentage reduction in minimum RMSE is 9.4%, 17.8%, and 4.2%, respectively, the percentage increase in the optimization time is 39.7%, 61.8%, and 27.3%, respectively, and a PC staircase lifting point setup method based on the small-sample database is proposed. The number of lifting points and lifting point locations of the PC staircase satisfying the multidimensional spatial feature constraints can be obtained by inputting the five design parameters of the PC staircase, namely, the number of treads, the height of the treads, the width of the treads, the width of the staircase, and the weight of the staircase, into the lifting point setup method proposed in this paper. The reliability of the precast reinforced concrete staircase lifting point setting method proposed in this paper when considering the multidimensional spatial constraint characteristics is verified by the precast staircases in deep shafts for assembly construction at the Chongqing metro station.
New Changes in Chinese Urban Tourism Pattern under the Impact of COVID-19 Pandemic: Based on Internet Attention
Authors: Sun Fengzhi , Li Zihan , Xu Mingzhi , Han Mingcan
Published: July 2024

Internet attention, as a reflection of the actual focus of the public, not only responds to potential tourism demand but also represents the overall perception and preference characteristics of tourists for a tourist destination. The study selected eight representative tourist cities in China as research objects. The impact of the COVID-19 pandemic on the tourism patterns of Chinese cities was analysed using various analytical methods, including the seasonal characteristic index, the entropy value method, the coefficient of variation, and the tourism background trend line model. The study revealed the following conclusions: (1) following the conclusion of the epidemic, potential tourism demand demonstrated a notable recovery in comparison to the epidemic period, yet remained below the level observed in the same period before the epidemic. (2) The seasonal variations in internet attention after the end of the epidemic demonstrated an increased degree of differentiation, with the tourism market tending to be more prosperous during the high season and less so during the low season. (3) The epidemic had a relatively minor impact on the internet attention of famous tourist attractions and natural ecological attractions. In contrast, it had a more significant influence on historical and cultural sites and modern amusement spots. The findings of this study offer insights that can inform the recovery and sustainable development of tourist cities in the post-pandemic era.
Comparison of Routes of Administration, Frequency, and Duration of Favipiravir Treatment in Mouse and Guinea Pig Models of Ebola Virus Disease
Authors: Johnson Dylan M. , Juelich Terry , Zhang Lihong , Smith Jennifer K. , Kalveram Birte K. , Perez David , Smith Jeanon , Grimes Michael R. , Garron Tania , Torres Maricela , Massey Shane , Brasel Trevor , Beasley David W. C. , Freiberg Alex N. , Comer Jason E.
Published: July 2024

Favipiravir is a ribonucleoside analogue that has been explored as a therapeutic for the treatment of Ebola Virus Disease (EVD). Promising data from rodent models has informed nonhuman primate trials, as well as evaluation in patients during the 2013–2016 West African EVD outbreak of favipiravir treatment. However, mixed results from these studies hindered regulatory approval of favipiravir for the indication of EVD. This study examined the influence of route of administration, duration of treatment, and treatment schedule of favipiravir in immune competent mouse and guinea pig models using rodent-adapted Zaire ebolavirus (EBOV). A dose of 300 mg/kg/day of favipiravir with an 8-day treatment was found to be fully effective at preventing lethal EVD-like disease in BALB/c mice regardless of route of administration (oral, intraperitoneal, or subcutaneous) or whether it was provided as a once-daily dose or a twice-daily split dose. Preclinical data generated in guinea pigs demonstrates that an 8-day treatment of 300 mg/kg/day of favipiravir reduces mortality following EBOV challenge regardless of route of treatment or duration of treatments for 8, 11, or 15 days. This work supports the future translational development of favipiravir as an EVD therapeutic.