bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of Nutraceutical Ingredient Combinations in the Management of Tension-Type Headaches with or without Sleep Disorders
Authors: Curatolo Paolo , Moavero Romina
Published: May 2021

Headache is the most common pain complaint in the pediatric population, with tension type headache (TTH) having a prevalence of 10–15% in children. Up to 70% of pediatric patients with chronic headache also experience sleep disruption, with a likely bidirectional relationship between headache and poor sleep. Treatment options include specific pharmacological approaches as well as non-pharmacological alternatives; nutraceuticals have the advantage of a relative lack of side effects. Exogenous melatonin has been shown to be useful and safe in improving sleep-wake cycles and quality of sleep in children, helping to regulate the circadian rhythm, with a secondary positive impact on headache. Supplementation with other nutraceutical ingredients, such as tryptophan, magnesium, and B vitamins, can have significant additional effects in children with primary headache, with or without sleep disorders. Tryptophan may reduce night awakenings and improve the efficiency of sleep. Primary headache has been related to low amounts of magnesium in serum, and integration with magnesium appears to be effective in reducing headache attacks without adverse effects. There are different observational reports and uncontrolled studies suggesting a possible synergistic effect for these nutraceuticals, but there is now a need for high-quality randomized controlled trials in order to confirm these positive preliminary findings.
Creatine in T Cell Antitumor Immunity and Cancer Immunotherapy
Authors: Li Bo , Yang Lili
Published: May 2021

Creatine is a broadly used dietary supplement that has been extensively studied for its benefit on the musculoskeletal system. Yet, there is limited knowledge regarding the metabolic regulation of creatine in cells beyond the muscle. New insights concerning various regulatory functions for creatine in other physiological systems are developing. Here, we highlight the latest advances in understanding creatine regulation of T cell antitumor immunity, a topic that has previously gained little attention in the creatine research field. Creatine has been identified as an important metabolic regulator conserving bioenergy to power CD8 T cell antitumor reactivity in a tumor microenvironment; creatine supplementation has been shown to enhance antitumor T cell immunity in multiple preclinical mouse tumor models and, importantly, to synergize with other cancer immunotherapy modalities, such as the PD-1/PD-L1 blockade therapy, to improve antitumor efficacy. The potential application of creatine supplementation for cancer immunotherapy and the relevant considerations are discussed.
Effect of Polydextrose/Fructooligosaccharide Mixture on Constipation Symptoms in Children Aged 4 to 8 Years
Authors: Toporovski Mauro Sérgio , de Morais Mauro Batista , Abuhab Abrão , Crippa Júnior Mauro Acir
Published: May 2021

Constipation is a frequent problem in children. We evaluated the effect of a mixture (polydextrose [PDX] and fructooligosaccharide [FOS]) in children with constipation. We performed a prospective interventional study with a mixture (PDX 4.17 g and FOS 0.45 g) in a daily dose of food supplement. The intervention lasted 45 days, with visits at 15, 30, and 45 days after administration. The sample comprised 105 patients, of whom 77 completed the intervention. A statistically significant reduction in the frequency of symptoms was observed at the end of the study. The frequency of children with fewer than three bowel movements per week dropped from 59.7% to 11.7%, and there was a decrease in the frequency of Bristol type 1 and 2 dry stools (68.8% to 7.8%), pain on defecation (79.2% to 10.4%), and fear of defecation (68.8% to 3.9%). The proportion of children with abdominal pain symptoms decreased from 84.2% to 2.6% at the end of the study. A relevant limitation of the present study was the lack of a control group treated with placebo. The administration of the PDX/FOS mixture was accompanied by a significant reduction in the frequency of constipation symptoms of the children evaluated. The tolerability was very good, and the rate of adverse effects was low.
Attenuated Microcirculation in Small Metastatic Tumors in Murine Liver
Authors: Ziemys Arturas , Simic Vladimir , Milosevic Miljan , Kojic Milos , Liu Yan Ting , Yokoi Kenji
Published: May 2021

Metastatic cancer disease is the major cause of death in cancer patients. Because those small secondary tumors are clinically hardly detectable in their early stages, little is known about drug biodistribution and permeation into those metastatic tumors potentially contributing to insufficient clinical success against metastatic disease. Our recent studies indicated that breast cancer liver metastases may have compromised perfusion of intratumoral capillaries hindering the delivery of therapeutics for yet unknown reasons. To understand the microcirculation of small liver metastases, we have utilized computational simulations to study perfusion and oxygen concentration fields in and around the metastases smaller than 700 µm in size at the locations of portal vessels, central vein, and liver lobule acinus. Despite tumor vascularization, the results show that blood flow in those tumors can be substantially reduced indicating the presence of inadequate blood pressure gradients across tumors. A low blood pressure may contribute to the collapsed intratumoral capillary lumen limiting tumor perfusion that phenomenologically corroborates with our previously published in vivo studies. Tumors that are smaller than the liver lobule size and originating at different lobule locations may possess a different microcirculation environment and tumor perfusion. The acinus and portal vessel locations in the lobule were found to be the most beneficial to tumor growth based on tumor access to blood flow and intratumoral oxygen. These findings suggest that microcirculation states of small metastatic tumors can potentially contribute to physiological barriers preventing efficient delivery of therapeutic substances into small tumors.
The Combination of Cell Cultured Technology and In Silico Model to Inform the Drug Development
Authors: Zhou Zhengying , Zhu Jinwei , Jiang Muhan , Sang Lan , Hao Kun , He Hua
Published: May 2021

Human-derived in vitro models can provide high-throughput efficacy and toxicity data without a species gap in drug development. Challenges are still encountered regarding the full utilisation of massive data in clinical settings. The lack of translated methods hinders the reliable prediction of clinical outcomes. Therefore, in this study, in silico models were proposed to tackle these obstacles from in vitro to in vivo translation, and the current major cell culture methods were introduced, such as human-induced pluripotent stem cells (hiPSCs), 3D cells, organoids, and microphysiological systems (MPS). Furthermore, the role and applications of several in silico models were summarised, including the physiologically based pharmacokinetic model (PBPK), pharmacokinetic/pharmacodynamic model (PK/PD), quantitative systems pharmacology model (QSP), and virtual clinical trials. These credible translation cases will provide templates for subsequent in vitro to in vivo translation. We believe that synergising high-quality in vitro data with existing models can better guide drug development and clinical use.
Plumbagin Elicits Cell-Specific Cytotoxic Effects and Metabolic Responses in Melanoma Cells
Authors: Zhang Haoran , Zhang Aijun , Gupte Anisha A. , Hamilton Dale J.
Published: May 2021

Melanoma is one of the most malignant skin cancers that require comprehensive therapies, including chemotherapy. A plant-derived drug, plumbagin (PLB), exhibits an anticancer property in several cancers. We compared the cytotoxic and metabolic roles of PLB in A375 and SK-MEL-28 cells, each with different aggressiveness. In our results, they were observed to have distinctive mitochondrial respiratory functions. The primary reactive oxygen species (ROS) source of A375 can be robustly attenuated by cell membrane permeabilization. A375 cell viability and proliferation, migration, and apoptosis induction are more sensitive to PLB treatment. PLB induced metabolic alternations in SK-MEL-28 cells, which included increasing mitochondrial oxidative phosphorylation (OXPHOS), mitochondrial ATP production, and mitochondrial mass. Decreasing mitochondrial OXPHOS and total ATP production with elevated mitochondrial membrane potential (MMP) were observed in PLB-induced A375 cells. PLB also induced ROS production and increased proton leak and non-mitochondria respiration in both cells. This study reveals the relationship between metabolism and cytotoxic effects of PLB in melanoma. PLB displays stronger cytotoxic effects on A375 cells, which exhibit lower respiratory function than SK-MEL-28 cells with higher respiratory function, and triggers cell-specific metabolic changes in accordance with its cytotoxic effects. These findings indicate that PLB might serve as a promising anticancer drug, targeting metabolism.
Anticancer Potential of Biogenic Silver Nanoparticles: A Mechanistic Study
Authors: Khan Mohd Shahnawaz , Alomari Alya , Tabrez Shams , Hassan Iftekhar , Wahab Rizwan , Bhat Sheraz Ahmad , Alafaleq Nouf Omar , Altwaijry Nojood , Shaik Gouse M. , Zaidi Syed Kashif , Nouh Wessam , Alokail Majed S. , Ismael Mohamed A.
Published: May 2021

The continuous loss of human life due to the paucity of effective drugs against different forms of cancer demands a better/noble therapeutic approach. One possible way could be the use of nanostructures-based treatment methods. In the current piece of work, we have synthesized silver nanoparticles (AgNPs) using plant (Heliotropiumbacciferum) extract using AgNO3 as starting materials. The size, shape, and structure of synthesized AgNPs were confirmed by various spectroscopy and microscopic techniques. The average size of biosynthesized AgNPs was found to be in the range of 15 nm. The anticancer potential of these AgNPs was evaluated by a battery of tests such as MTT, scratch, and comet assays in breast (MCF-7) and colorectal (HCT-116) cancer models. The toxicity of AgNPs towards cancer cells was confirmed by the expression pattern of apoptotic (p53, Bax, caspase-3) and antiapoptotic (BCl-2) genes by RT-PCR. The cell viability assay showed an IC50 value of 5.44 and 9.54 µg/mL for AgNPs in MCF-7 and HCT-116 cell lines respectively. We also observed cell migration inhibiting potential of AgNPs in a concentration-dependent manner in MCF-7 cell lines. A tremendous rise (150–250%) in the production of ROS was observed as a result of AgNPs treatment compared with control. Moreover, the RT-PCR results indicated the difference in expression levels of pro/antiapoptotic proteins in both cancer cells. All these results indicate that cell death observed by us is mediated by ROS production, which might have altered the cellular redox status. Collectively, we report the antimetastasis potential of biogenic synthesized AgNPs against breast and colorectal cancers. The biogenic synthesis of AgNPs seems to be a promising anticancer therapy with greater efficacy against the studied cell lines.
Gene Expression in Parthenogenic Maize Proembryos
Authors: Volokhina Irina , Gusev Yury , Moiseeva Yelizaveta , Gutorova Olga , Fadeev Vladimir , Chumakov Mikhail
Published: May 2021

Angiosperm plants reproduce both sexually and asexually (by apomixis). In apomictic plants, the embryo and endosperm develop without fertilization. Modern maize seems to have a broken apomixis-triggering mechanism, which still works in Tripsacum and in Tripsacum–maize hybrids. For the first time, maize lines characterized by pronounced and inheritable high-frequency maternal parthenogenesis were generated 40 years ago, but there are no data on gene expression in parthenogenic maize proembryos. Here we examined for the first time gene expression in parthenogenic proembryos isolated from unpollinated embryo sacs (ESs) of a parthenogenic maize line (AT-4). The DNA-methylation genes (dmt103, dmt105) and the genes coding for the chromatin-modifying enzymes (chr106, hdt104, hon101) were expressed much higher in parthenogenic proembryos than in unpollinated ESs. The expression of the fertilization-independent endosperm (fie1) genes was found for the first time in parthenogenic proembryos and unpollinated ESs. In parthenogenic proembryos, the Zm_fie2 gene was expressed up to two times higher than it was expressed in unpollinated ESs.
Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review
Authors: Riha Shaima Maliha , Maarof Manira , Fauzi Mh Busra
Published: May 2021

Skin tissue engineering has made remarkable progress in wound healing treatment with the advent of newer fabrication strategies using natural/synthetic polymers and stem cells. Stem cell therapy is used to treat a wide range of injuries and degenerative diseases of the skin. Nevertheless, many related studies demonstrated modest improvement in organ functions due to the low survival rate of transplanted cells at the targeted injured area. Thus, incorporating stem cells into biomaterial offer niches to transplanted stem cells, enhancing their delivery and therapeutic effects. Currently, through the skin tissue engineering approach, many attempts have employed biomaterials as a platform to improve the engraftment of implanted cells and facilitate the function of exogenous cells by mimicking the tissue microenvironment. This review aims to identify the limitations of stem cell therapy in wound healing treatment and potentially highlight how the use of various biomaterials can enhance the therapeutic efficiency of stem cells in tissue regeneration post-implantation. Moreover, the review discusses the combined effects of stem cells and biomaterials in in vitro and in vivo settings followed by identifying the key factors contributing to the treatment outcomes. Apart from stem cells and biomaterials, the role of growth factors and other cellular substitutes used in effective wound healing treatment has been mentioned. In conclusion, the synergistic effect of biomaterials and stem cells provided significant effectiveness in therapeutic outcomes mainly in wound healing improvement.
Preparation of Polyetherimide Nanoparticles by a Droplet Evaporation-Assisted Thermally Induced Phase-Separation Method
Authors: Zhu Peng , Zhang Huapeng , Lu Hongwei
Published: May 2021

The droplet evaporation effect on the preparation of polyetherimide (PEI) nanoparticles by thermally induced phase separation (TIPS) was studied. PEI nanoparticles were prepared in two routes. In route I, the droplet evaporation process was carried out after TIPS. In route II, the droplet evaporation and TIPS processes were carried out simultaneously. The surface tension and shape parameters of samples were measured via a drop shape analyzer. The Z-average particle diameter of PEI nanoparticles in the PEI/dimethyl sulfoxide solution (DMSO) suspension at different time points was tested by dynamic light scattering, the data from which was used to determine the TIPS time of the PEI/DMSO solution. The natural properties of the products from both routes were studied by optical microscope, scanning electron microscope and transmission electron microscope. The results show that PEI nanoparticles prepared from route II are much smaller and more uniform than that prepared from route I. Circulation flows in the droplet evaporation were indirectly proved to suppress the growth of particles. At 30 °C, PEI solid nanoparticles with 193 nm average particle size, good uniformity, good separation and good roundness were obtained. Route I is less sensitive to temperature than route II. Samples in route I were still the accumulations of micro and nanoparticles until 40 °C instead of 30 °C in route II, although the particle size distribution was not uniform. In addition, a film structure would appear instead of particles when the evaporation temperature exceeds a certain value in both routes. This work will contribute to the preparation of polymer nanoparticles with small and uniform particle size by TIPS process from preformed polymers.
Fused Filament Fabrication Based on Polyhydroxy Ether (Phenoxy) Polymers and Related Properties
Authors: Brauner Christian , Küng Marco , Arslan Delal , Maurer Christoph
Published: May 2021

This paper describes the first-time application of polyhydroxy ether polymers, so-called phenoxy, to fused filament fabrication (FFF). Phenoxy is an amorphous thermoplastic polymer that is based on the same building blocks as epoxide resins. This similarity creates some unique properties such as dissolution to epoxide systems, which is why phenoxy is used as an additive for toughening. In this study, the processing parameters were characterized, a filament was extruded and applied to FFF printing, and the final mechanical characteristics were determined. The study concludes with a comparison with other standard FFF materials.
Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition
Authors: Volova Tatiana G. , Golubev Alexey I. , Nemtsev Ivan V. , Lukyanenko Anna V. , Dudaev Alexey E. , Shishatskaya Ekaterina I.
Published: May 2021

The study reports results of using a CO2-laser in continuous wave (3 W; 2 m/s) and quasi-pulsed (13.5 W; 1 m/s) modes to treat films prepared by solvent casting technique from four types of polyhydroxyalkanoates (PHAs), namely poly-3-hydroxybutyrate and three copolymers of 3-hydroxybutyrate: with 4-hydroxybutyrate, 3-hydroxyvalerate, and 3-hydroxyhexanoate (each second monomer constituting about 30 mol.%). The PHAs differed in their thermal and molecular weight properties and degree of crystallinity. Pristine films differed in porosity, hydrophilicity, and roughness parameters. The two modes of laser treatment altered these parameters and biocompatibility in diverse ways. Films of P(3HB) had water contact angle and surface energy of 92° and 30.8 mN/m, respectively, and average roughness of 144 nm. The water contact angle of copolymer films decreased to 80–56° and surface energy and roughness increased to 41–57 mN/m and 172–290 nm, respectively. Treatment in either mode resulted in different modifications of the films, depending on their composition and irradiation mode. Laser-treated P(3HB) films exhibited a decrease in water contact angle, which was more considerable after the treatment in the quasi-pulsed mode. Roughness parameters were changed by the treatment in both modes. Continuous wave line-by-line irradiation caused formation of sintered grooves on the film surface, which exhibited some change in water contact angle (76–80°) and reduced roughness parameters (to 40–45 mN/m) for most films. Treatment in the quasi-pulsed raster mode resulted in the formation of pits with no pronounced sintered regions on the film surface, a more considerably decreased water contact angle (to 67–76°), and increased roughness of most specimens. Colorimetric assay for assessing cell metabolic activity (MTT) in NIH 3T3 mouse fibroblast culture showed that the number of fibroblasts on the films treated in the continuous wave mode was somewhat lower; treatment in quasi-pulsed radiation mode caused an increase in the number of viable cells by a factor of 1.26 to 1.76, depending on PHA composition. This is an important result, offering an opportunity of targeted surface modification of PHA products aimed at preventing or facilitating cell attachment.
Influence of Different Conditioning Treatments on the Bond Integrity of Root Dentin to rGO Infiltrated Dentin Adhesive. SEM, EDX, FTIR and MicroRaman Study
Authors: Alqarawi Firas K. , Alkahtany Mazen F. , Almadi Khalid H. , Ben Gassem Afnan A. , Alshahrani Faris A. , AlRefeai Mohammad H. , Farooq Imran , Vohra Fahim , Abduljabbar Tariq
Published: May 2021

The present study aimed to synthesize and equate the mechanical properties and dentin interaction of two adhesives; experimental adhesive (EA) and 5 wt.% reduced graphene oxide rGO) containing adhesive. Scanning electron microscopy (SEM)-Energy-dispersive X-ray spectroscopy (EDX), Micro-Raman spectroscopy, push-out bond strength test, and Fourier Transform Infrared (FTIR) spectroscopy were employed to study nano-bond strength, degree of conversion (DC), and adhesive-dentin interaction. The EA was prepared, and rGO particles were added to produce two adhesive groups, EA-rGO-0% (control) and rGO-5%. The canals of sixty roots were shaped and prepared, and fiber posts were cemented. The specimens were further alienated into groups based on the root canal disinfection technique, including 2.5% sodium hypochlorite (NaOCl), Photodynamic therapy (PDT), and ER-CR-YSGG laser (ECYL). The rGO nanoparticles were flake-shaped, and EDX confirmed the presence of carbon (C). Micro-Raman spectroscopy revealed distinct peaks for graphene. Push-out bond strength test demonstrated highest values for the EA-rGO-0% group after NaOCl and PDT conditioning whereas, rGO-5% showed higher values after ECYL conditioning. EA-rGO-0% presented greater DC than rGO-5% adhesive. The rGO-5% adhesive demonstrated comparable push-out bond strength and rheological properties to the controls. The rGO-5% demonstrated acceptable DC (although lower than control group), appropriate dentin interaction, and resin tag establishment.
Physicochemical Properties of Chitosan from Two Commonly Reared Edible Cricket Species, and Its Application as a Hypolipidemic and Antimicrobial Agent
Authors: Malm Morgan , Liceaga Andrea M.
Published: May 2021

Insect-derived chitin and chitosan have gained interest as alternative sources to that derived from crustaceans; however, little information is available on chitin from the house cricket (Acheta domesticus) and tropical banded cricket (Gryllodes sigillatus), two cricket species commonly reared in the United States for human consumption. In this study, chitin was successfully isolated and purified from these two cricket species; using FTIR, chitins were found to be in alpha-crystalline form. Cricket chitosan was produced from both species with varying degrees of deacetylation (DDA) by varying alkaline conversion duration. G. sigillatus chitosan was larger (524 kDa) than A. domesticus chitosan (344 kDa). Both cricket chitosans showed similar (p > 0.05) lipid-binding capacity to that of shrimp chitosan. Both chitosans were as effective at inhibiting microbial growth of surrogate foodborne pathogens as the commercial shrimp chitosan. At a concentration of 0.50 mg/mL cricket chitosan, approximately 100% of Listeria innocua growth was inhibited, due to a contribution of both chitosan and the solvent-acetic acid. At the same concentration, growth of Escherichia coli was inhibited 90% by both cricket chitosan samples with ~80% DDA, where a decrease in the DDA led to decreased antimicrobial activity. However, varying the DDA had no effect on chitosan’s lipid-binding capacity. As more edible insects become a normalized protein source in our diet, the use of by-products, such as chitin and chitosan, derived from insect protein processing, show promising applications for the pharmaceutical and food industries.
An Experimental Investigation of Water Vapor Condensation from Biofuel Flue Gas in a Model of Condenser, (1) Base Case: Local Heat Transfer without Water Injection
Authors: Poškas Robertas , Sirvydas Arūnas , Kulkovas Vladislavas , Poškas Povilas
Published: May 2021

Waste heat recovery from flue gas based on water vapor condensation is an important issue as the waste heat recovery significantly increases the efficiency of the thermal power units. General principles for designing of this type of heat exchangers are known rather well; however, investigations of the local characteristics necessary for the optimization of those heat exchangers are very limited. Investigations of water vapor condensation from biofuel flue gas in the model of a vertical condensing heat exchanger were performed without and with water injection into a calorimetric tube. During the base-case investigations, no water was injected into the calorimetric tube. The results showed that the humidity and the temperature of inlet flue gas have a significant effect on the local and average heat transfer. For some regimes, the initial part of the condensing heat exchanger was not effective in terms of heat transfer because there the flue gas was cooled by convection until its temperature reached the dew point temperature. The results also showed that, at higher Reynolds numbers, there was an increase in the length of the convection prevailing region. After that region, a sudden increase was observed in heat transfer due to water vapor condensation.
In Situ Bio-Methanation Modelling of a Randomly Packed Gas Stirred Tank Reactor (GSTR)
Authors: Mazzeo Leone , Signorini Antonella , Lembo Giuseppe , Bavasso Irene , Di Palma Luca , Piemonte Vincenzo
Published: May 2021

In situ Bio-Methanation (BM) is a recently developed biogas upgrading technique which finds application also in the Power to Gas (P2G) field. In this study a novel configuration of BM digester, the randomly packed Gas Stirred Tank Reactor (GSTR), was modelled. A 49 L reactor, in thermophilic conditions (55 °C) and at atmospheric pressure, was filled up with random packing on which the microbial populations could adhere. The feedstock used was Second Cheese Whey (SCW), liquid waste of cheese factories, rich in lactose (38 g/L), and its flowrate was chosen to obtain a Hydraulic Retention Time (HRT) of 30 days. The process was analyzed for different hydrogen inlet flowrates of 10 mL/min and 50 mL/min. The produced biogas was also recirculated in the reactor in order to transfer, into the liquid phase, as much hydrogen as possible. The model parameters were estimated by means of stationary state information of the reactor working without hydrogen injection, while a dynamical fitting was necessary to evaluate the value of the hydrogen mass transfer coefficient during BM. The model well described the reactor behavior and, by means of a dimensionless analysis in which the numbers of Stanton (St) and β were defined, it was found out that the mass transfer coefficient is the limiting step of the process.
Heat Transfer and Hydrodynamics in Stirred Tanks with Liquid-Solid Flow Studied by CFD–DEM Method
Authors: Luo Xiaotong , Yu Jiachuan , Wang Bo , Wang Jingtao
Published: May 2021

The heat transfer and hydrodynamics of particle flows in stirred tanks are investigated numerically in this paper by using a coupled CFD–DEM method combined with a standard k-e turbulence model. Particle–fluid and particle–particle interactions, and heat transfer processes are considered in this model. The numerical method is validated by comparing the calculated results of our model to experimental results of the thermal convection of gas-particle flows in a fluidized bed published in the literature. This coupling model of computational fluid dynamics and discrete element (CFD–DEM) method, which could calculate the particle behaviors and individual particle temperature clearly, has been applied for the first time to the study of liquid-solid flows in stirred tanks with convective heat transfers. This paper reports the effect of particles on the temperature field in stirred tanks. The effects on the multiphase flow convective heat transfer of stirred tanks without and with baffles as well as various heights from the bottom are investigated. Temperature range of the multiphase flow is from 340 K to 350 K. The height of the blade is varied from about one-sixth to one-third of the overall height of the stirred tank. The numerical results show that decreasing the blade height and equipping baffles could enhance the heat transfer of the stirred tank. The calculated temperature field that takes into account the effects of particles are more instructive for the actual processes involving solid phases. This paper provides an effective method and is helpful for readers who have interests in the multiphase flows involving heat transfers in complex systems.
Propagation of CH4-N2O-N2 Flames in a Closed Spherical Vessel
Authors: Mitu Maria , Giurcan Venera , Movileanu Codina , Razus Domnina , Oancea Dumitru
Published: May 2021

Flammable fuel-N2O mixtures raise safety and environmental protection issues in areas where these mixtures are used (such as: industry, research, internal combustion engines). Therefore, it is important to know their laminar combustion velocities and propagation speeds—important safety parameters for design of active protection devices against gas explosions and corresponding safety recommendations. In this paper, the laminar combustion velocities of N2-diluted CH4-N2O flames, obtained in experiments on outwardly propagating flames, at various initial pressures (within 0.5–2.0 bar) and room temperature, are reported. The experiments were made in a 0.5 L spherical cell with central ignition. The laminar combustion velocities were calculated from the constants of cubic law of flame propagation during the early stage of closed cell explosions and the expansion coefficients of unburned flammable mixtures, using the adiabatic model of the flame propagation. The expansion coefficients were determined from equilibrium calculations on flames propagating under isobaric conditions. The laminar combustion velocities were compared with data reported in the literature. Using the laminar combustion velocities and the expansion coefficients, the propagation speeds of N2-diluted CH4-N2O flames were calculated. Both laminar combustion velocities and propagation speeds decrease with the initial pressure increase.
Special Issue on “Advances in Microfluidics Technology for Diagnostics and Detection”
Authors: Kinahan David J. , Mager Dario , Vereshchagina Elizaveta , Miyazaki Celina M.
Published: May 2021

In recent years microfluidics and lab-on-a-chip havecome to the forefront in diagnostics and detection [...]
Investigation of Orthopedic Prosthesis Socket Management after Transfemoral Amputation by Expert Survey
Authors: Carabello Alina , Schellnock Julia , Schleifenbaum Stefan , Hömme Ann-Kathrin , Felderhoff Thomas , Menküc Benjamin , Drossel Welf-Guntram
Published: May 2021

Prosthesis treatment requires the close interaction of different actors. In fitting prostheses to patients, special attention is given to the manufacturing of the socket. The continuous development of the technologies involved in the fitting and optimization of prostheses is shown in the literature. The assessment of orthopedic technicians and their influence in the process is thus far largely unexplored. Ten orthopedic technicians were interviewed about the socket fitting process after transfemoral amputation. The research goal was to clarify the socket treatment process with regards to the German context. The results showed that the orthopedic technicians focussing on the patient during the fitting process. This study underlines the importance of interaction and empathy. Volume fluctuations are decisive within the treatment process and are interactively influenced by various factors. Furthermore, the research emphasizes the need for appropriate assistive technologies and the potential for the further development of existing systems.
Western Diet Induced Remodelling of the Tongue Proteome
Authors: Dutt Mriga , Ng Yaan-Kit , Molendijk Jeffrey , Karimkhanloo Hamzeh , Liao Luoping , Blazev Ronnie , Montgomery Magdalene K. , Watt Matthew J. , Parker Benjamin L.
Published: May 2021

The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and digestion. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest that our perceptions of taste and food preference are remodelled following chronic consumption of Western diets rich in carbohydrate and fats. Our sensitivity to taste and also to metabolising Western diets may be a key factor in the rising prevalence of obesity; however, a systems-wide analysis of the tongue is lacking. Here, we defined the proteomic landscape of the mouse tongue and quantified changes following chronic consumption of a chow or Western diet enriched in lipid, fructose and cholesterol for 7 months. We observed a dramatic remodelling of the tongue proteome including proteins that regulate fatty acid and mitochondrial metabolism. Furthermore, the expressions of several receptors, metabolic enzymes and hormones were differentially regulated, and are likely to provide novel therapeutic targets to alter taste perception and food preference to combat obesity.
‘Come, Follow Me’, The Sacralising of the Home, and The Guardian of the Family: How Do European Women Negotiate the Domestic Space in the Church of Jesus Christ of Latter-Day Saints?
Authors: Halford Alison
Published: May 2021

In October 2018, the Prophet Russell M. Nelson informed members of the Church of Jesus Christ of Latter-day Saints that the Church teaching curriculum would shift focus away from lessons taught on Sunday. Instead, members were now asked to engage with ‘home-centred, church-supported’ religious instruction using the Church materials ‘Come, Follow Me’. In a religion where Church leaders still defend the idealised family structure of a stay-at-home mother and a father as the provider, the renewed emphasis on the domestic sphere as the site for Church teaching could also reinforce traditional Mormon gender roles. This article draws upon the lived religion of Latter-day Saint women in Sweden, Greece and England to understand how they negotiate gender in their homes. Looking at the implementation of ‘Come, Follow Me’ of sacralising of the home as a gendered practice, there appears to be a reinforcing of the primacy of the domestic space in the reproduction of religious practices and doctrinal instruction. Simultaneously, in conceptualising a gender role, the guardian of the family, I show the ways that European Latter-day Saint women are providing, protecting and nurturing their families. The domestic space then becomes instrumental in providing space for more nuanced, complex gender constructs that accommodate Mormon beliefs, cultural context and secular notions of gender without destabilising the institutional structure.
Militant Liturgies: Practicing Christianity with Kierkegaard, Bonhoeffer, and Weil
Authors: Simmons J. Aaron
Published: May 2021

Traditional philosophy of religion has tended to focus on the doxastic dimension of religious life, which although a vitally important area of research, has often come at the cost of philosophical engagements with religious practice. Focusing particularly on Christian traditions, this essay offers a sustained reflection on one particular model of embodied Christian practice as presented in the work of Søren Kierkegaard. After a discussion of different notions of practice and perfection, the paper turns to Kierkegaard’s conception of the two churches: the Church Triumphant and the Church Militant. Then, in light of Kierkegaard’s defense of the latter and critique of the former, it is shown that Kierkegaard’s specific account gets appropriated and expanded in Dietrich Bonhoeffer’s account of “costly grace” and “religionless Christianity,” and Simone Weil’s conception of “afflicted love.” Ultimately, it is suggested that these three thinkers jointly present a notion of “militant liturgies” that offers critical and constructive resources for contemporary philosophy of religion.
Elevation Spatial Variation Analysis and Compensation in GEO SAR Imaging
Authors: Chang Faguang , Li Dexin , Dong Zhen , Huang Yang , He Zhihua , Chen Xing
Published: May 2021

Due to geosynchronous synthetic aperture radar’s (GEO SAR) high orbit and low relative speed, the integration time reaches up to hundreds of seconds for a fine resolution. The short revisit cycle is essential for remote sensing applications such as disaster monitoring and vegetation measurements. Three-dimensional (3D) scene imaging mode is crucial for long-term observation using GEO SAR. However, this mode will bring a new kind of space-variant error in elevation. In this paper, we focus on the analysis of the elevation space-variant error. First, the decorrelation problems caused by the spatial variation are presented. Second, by combining with the SAR imaging geometry, the elevation spatial variation is decomposed into two-dimensional (2D) space variation of range and azimuth. Third, an imaging algorithm is proposed to solve the 3D space variation and improve the focusing depth. Finally, simulations with dot-matrix targets and distributed targets are performed to validate the imaging method.
Remote and Proximal Assessment of Plant Traits
Authors: Herrmann Ittai , Berger Katja
Published: May 2021

The inference of functional vegetation traits from remotely sensed signals is key to providing efficient information for multiple plant-based applications and to solve related problems [...]
Applicability of Fuzzy Logic and Artificial Neural Network for Unpaved Airfield Surface Bearing Strength Prediction
Authors: Cicmanec Ludek
Published: May 2021

The main objective of this paper is to describe a building process of a model predicting the soil strength at unpaved airport surfaces (unpaved runways, safety areas in runway proximity, runway strips, and runway end safety areas). The reason for building this model is to partially substitute frequent and meticulous inspections of an airport movement area comprising the bearing strength evaluation and provide an efficient tool to organize surface maintenance. Since the process of building such a model is complex for a physical model, it is anticipated that it might be addressed by a statistical model instead. Therefore, fuzzy logic (FL) and artificial neural network (ANN) capabilities are investigated and compared with linear regression function (LRF). Large data sets comprising the bearing strength and meteorological characteristics are applied to train the likely model variations to be subsequently compared with the application of standard statistical quantitative parameters. All the models prove that the inclusion of antecedent soil strength as an additional model input has an immense impact on the increase in model accuracy. Although the M7 model out of the ANN group displays the best performance, the M3 model is considered for practical implications being less complicated and having fewer inputs. In general, both the ANN and FL models outperform the LRF models well in all the categories. The FL models perform almost equally as well as the ANN but with slightly decreased accuracy.
Modeling and Optimization of Membrane Process for Salinity Gradient Energy Production
Authors: Song Lianfa
Published: May 2021

When hydraulic pressure was added on the feed side of the membrane in the otherwise conventional pressure retarded osmosis (PRO) process, the production rate of the salinity gradient energy could be significantly increased by manipulating the hydraulic pressures on both sides of the membrane. With hydraulic pressure added on the feed side of the membrane, much higher water flux could be obtained than that under the osmotic pressure of the same value. The osmotic pressure of the draw solution, instead of drawing water through the membrane, was mainly reserved to increase the hydraulic pressure of the permeate. In this way, orders of magnitude higher power density than that in the conventional PRO can be obtained with the same salinity gradient. At the optimal conditions, it was demonstrated that the energy production rates that were much higher than the economical breakeven point could be obtained from the pair of seawater and freshwater with the currently available semipermeable membranes.