bluuebunny/crossref_metadata_2025 huggingface dataset:
CHALLENGES AFFECTING THE COMMERCIALIZATION OF INTELLECTUAL PROPERTY RIGHTS IN THE GAMBIA’S TEXTILE INDUSTRY
Authors: Ceesay Muhamed Lamin
Published: February 2025

There has been significant deterioration in the textile industry of The Gambia over the years which has resulted to loss of jobs, minimal revenue and preference for foreign goods over locally made. As a result, this study examines the challenges affecting the use of intellectual property rights in the textile industry of The Gambia to maximize the quality and efficiency of their goods and service. Participants were selected through a purposive sampling, and data for this research was collected through focus group discussion with producers, retailers and users of textile; unstructured interviews with three heads of institutions; and an observational study with producers. The data was analysed using the thematic analysis. The findings of the research reveal that the main challenges encountered by the textile industry regarding the use of intellectual property rights in their businesses is due to lack of awareness since most producers, and retailers have never heard of intellectual property rights nor obtained any trainings on it. Also, lack of enforcement against unlawful copying of textiles by infringers has been a great discouragement for many producers and retailers in the textile industry of The Gambia not to acquire intellectual property rights. Furthermore, lack of financial support from the government has affected the growth and productivity of the textile industry of The Gambia. Therefore, the textile industry of The Gambia should receive constant awareness trainings from intellectual property rights which will encourage them to appreciate, register and use their intellectual property rights over the creative works. The Gambian government should also provide the required facilities to police and border control agencies to enforce against unlawful copies of locally made textiles and other sorts of infringements. Equally, The Gambian government should provide enough financial support and award grants to the textile industry.
A Fuzzification Measure of Robust Design in Condition of "Desired Target Being Best" in Design
Authors: Zheng Maosheng , Yu Jie
Published: February 2025

In the present article, a fuzzification measure of robust design in condition of "desired target being best" is regulated, which consists of the "complement" of the membership value of objective response and PMOO. The mean value of "complement" of the membership value of a set of test data of objective response belonging to its desired target value in fuzzification is taken as an indicator to join the assessment of the 1st part of partial preferable probability of the objective; the dispersion of a set of test data in term of membership with regard to the desired target value is taken as the other indicator to participate the assessment of the 2nd part of partial preferable probability of the objective. Moreover, the fuzzification measure of robust design is regulated in term of PMOO. As utilizations, two instances are presented to illuminate the regulation in design.
OBTAINING A NEW STRAIN OF ASPERGILLUS TERREUS HAVING ANTIFUNGAL ACTIVITY AGAINST FUSARIUM OXYSPORUM
Authors:   Russian Biotechnological University, Moscow, Tsyganov V.A. ,   All-Russian Research Institute of Phytopathology, Moscow, Glagoleva E.V. , Djavakhia V.V. , Voinova T.M.
Published: February 2025

Aspergillus terreus strain 33–127 was obtained from A. terreus 25–33 strain, a low-productivity producer of mevinoline
(35 mg/l). The obtaining methodology was the stepwise induced UV mutagenesis. The obtained strain has increased productivity in the
target secondary metabolite (1170 mg/l). The inactivated biomass of the resulting strain was tested for the ability to inhibit the growth
of the phytopathogenic test fungus Fusarium oxysporum MP-14-6. It was revealed that the tested product has pronounced antifungal
activity by suppressing the growth of the test culture up to over 50 %.
A NOVEL HYBRID Β-AMYLASE: CHARACTERISATION AND BIOTECHNOLOGICAL POTENTIAL
Authors:   National Research Centre “Kurchatov Institute”, Moscow, Chepurko V.G. , Sineokiy S.P. , Gordeeva T.L.
Published: February 2025

The genes encoding β-amylase from Priestia megaterium and hybrid β-amylase Hyb1, consisting of the catalytic domain of
β-amylase from Priestia flexa and the starch-binding domain of β-amylase from P. megaterium, were expressed in Komagataella phaffii
cells. In contrast to β-amylase from P. megaterium, the Hyb1 enzyme had an extended pH range and increased thermostability. Hyb1
retained about 67 % of activity after incubation for 40 min at 50 °C.
MYELOPEROXIDASE AS A FUNCTIONAL MARKER OF INFLAMMATION ON THE EXAMPLE OF PARASALMO MYKISS
Authors:   Petrozavodsk State University, Chechkova N.A.
Published: February 2025

The study examines the physiological role of myeloperoxidase as an indicator of the functional state of neutrophilic granulocytes. Using four age groups of Parasalmo mykiss as an example, a reliable increase in enzyme activity with age and depending on
environmental conditions was revealed. The results of the study are necessary to characterize the state of non-specific cellular defense
factors in aquaculture objects.
PERFORMANCE OF APIS MELLIFERA USE IN IN VITRO PARASITOLOGICAL RESEARCH
Authors:   Kazan Federal University, Shamaev N.D. , Shuralev E.A. , Mukminov M.N. ,   Kazan State Medical Academy,   Kazan State Medical University,   Bauman Kazan State Academy of Veterinary Medicine
Published: February 2025

European honey bee breeds Apis mellifera are experiencing a decline due to the nosemosis disease caused by microsporidia
of the genus Nosema. This disease is difficult to study due to multiple stressors and lack of reliable bioassays. In vitro incubation
techniques can establish the diet composition of individual colonies, but high mortality rates have been reported. This study aimed to
develop an improved in vitro incubation protocol to assess threats to honey bee growth and survival caused by Nosema microsporidia.
The study improved parameters such as diet composition and found that Galleria mellonella extract was effective for general in vitro
honey bee rearing.
ANTIOXIDANT AND ANTIPLATELET PROPERTIES OF NANODISPERSIONS WITH LIPOIC ACID
Authors:   MIREA — Russian Technological University, Moscow, Shchelkonogov V.A. ,   Pirogov Russian National Research Medical University, Moscow,   Kotelnikov Institute of Radio Engineering and Electronics RAS, Fryazino, Kozlova O.A. , Inshakova A.M. , Darnotuk E.S. , Shipelova A.V. , Shastina N.S. , Baranova O.A. , Chekanov A.V. , Kazarinov K.D. , Solov’eva E.Yu. , Fedin A.I.
Published: February 2025

Nanodispersions (NDs) with lipoic acid (LA) with a particle size 25–350 nm were obtained, characterized by its slow release
from nanoparticles and high stability during long-term storage at room temperature. In nanoemulsions, it was possible to increase the
solubilization of LA by 1.5 times compared with liposomes. It was shown that NPs with LA have pronounced antioxidant and antiplatelet properties.
STUDY OF THE ROLE OF EPHAPTIC COUPLING OF CARDIOMYOCYTES IN THE FORMATION OF UNIDIRECTIONAL CONDUCTION BLOCK
Authors:   Moscow Institute of Physics and Technology, Dolgoprudny, Bakumenko S.S. ,   Moscow Regional Research Clinical Institute named after M.F. Vladimirsky,   ITMO University, Saint Petersburg, Romanova S.A. , Aitova A.A. , Naumov V.D. , Semidetnov I.S. , Berezhnoi A.K. , Slotvitsky M.M. , Tsvelaya V.A. , Agladze K.I.
Published: February 2025

Cardiac arrhythmias represent a major cause of cardiovascular-related mortality. This work investigates the influence of functional heterogeneity of cardiac tissue on the occurrence of arrhythmias and develops cardiotoxicity screening systems that take these
heterogeneities into account. The main goal of the study is to develop in vitro and in silico screening systems for cardiotoxicity that take
into account the heterogeneity of cardiac tissue. The experimental part of the study includes culturing cardiomyocytes isolated from
human atrial tissue, studying the elasticity of their membranes using atomic force microscopy, immunocytochemical staining of cells
and analyzing cell morphology using confocal microscopy. The in silico approach is to create a heterogeneous model of cardiac tissue,
which is used to study the influence of intercellular heterogeneities on the conditions for the formation of primary reentry waves. For
this purpose, computer vision and transmembrane current modeling techniques are applied. The study makes a significant contribution
to the understanding of the mechanisms of cardiac arrhythmias and offers new approaches to the assessment of cardiotoxicity of drugs.
The developed screening systems may be useful for predicting the cardiotoxicity of new drugs, which is of great importance for medicine and pharmacology.
DEVELOPMENT OF A METHOD FOR THE SYNTHESIS OF A DOPED POLYMER MATRIX FOR THE CREATION AN INNOVATIVE ADAPTOGENIC MEDICINE
Authors:   Petrozavodsk State University, Berezina O.Ya. , Erokhova P.I. , Shirokaya A.A. , Lyashkov P.O.
Published: February 2025

Methods of synthesizing a matrix consisting of nanofilaments of water- and ethyl alcohol-soluble biocompatible polymer polyvinylpyrrolodone doped with iron ions of different concentrations are considered. The synthesis parameters by electrospinning method
are described. The polymeric matrix is fabricated to produce a new adaptogenic medicine by soft immobilization of lactobacilli.
Cobertura vacinal no primeiro ano de vida no município de Campina Grande – PB
Authors: Estevão Marna Maria Araújo Miranda , Silveira Maria Jeanette de Oliveira , Miranda Marthana de Maria Araújo , Estevão Túlio de Almeida , Miranda Marcela Maria Araújo , Abrantes Rafaela Simão de , Silva Juliana Jamaica Sousa da
Published: February 2025

Objetivo: Analisar a Cobertura Vacinal (CV) de crianças no primeiro ano de vida no município de Campina Grande, Paraíba, entre os anos de 2019 e 2024. Métodos: Trata-se de um estudo retrospectivo temporal, quantitativo, com análise descritiva. Foram utilizados os dados do DATA-SUS e do Painel de Vacinação da Covid-19 do Ministério da Saúde, disponíveis em plataformas digitais de livre acesso. A CV foi verificada para as vacinas preconizadas pelo Programa Nacional de Imunização (PNI) e previstas no Calendário Nacional de Vacinação (CNV) para crianças de até 1 ano de idade. Resultados: Somente no ano de 2019 houve o alcance da meta vacinal para a maioria das vacinas. A partir de 2020 todas as taxas caíram sobremaneira. Nos anos de 2020 e 2022 houve alcance da meta vacinal para a BCG e Hepatite. Nos anos de 2021, 2023 e 2024, nenhuma vacina atingiu CV preconizada. Os piores resultados foram verificados para as vacinas da febre amarela, varicela e Covid-19. Apesar disso, de modo geral, as taxas vacinais aumentaram a partir de 2023. Conclusão: O município apresenta um cenário ameaçador para a saúde infantil. Sugere-se a criação de estratégias de educação em saúde que disseminem informações nos diferentes estratos populacionais.
ОЦЕНКА КАЧЕСТВА ЗОЛОШЛАКОВЫХ ОТХОДОВ ТЭС И ЭФФЕКТИВНОСТИ ИХ ПЕРЕРАБОТКИ
Authors: ШУБОВ Л Я. , ДОРОНКИНА И Г. , БОРИСОВА О Н.
Published: February 2025

На основе аналитического исследования совокупности запатентованных технологических решений предложена методология оценки качества ЗШО как объекта переработки и утилизации. Дано обоснование целесообразности применения такой методологии. Приведены ресурсосберегающие технологии переработки отходов, прошедшие полупромышленную и опытно-промышленную апробацию. Рассмотрены причины целесообразности масштабного вовлечения в переработку и утилизацию техногенного сырья, сосредоточенного в искусственных скоплениях отходов, загрязняющих окружающую среду. Отмечено: ресурсоэффективность характеризует систему ресурсосбережения с точки зрения степени утилизации отходов и качества получаемой продукции (при минимизации затрат и экологических рисков). Отмечены критерии ресурсной эффективности переработки отходов и вторсырья: степень утилизации отходов, технологические показатели применяемых процессов, показатели новой продукции, удельный расход энергии. Дана оценка ресурсоэффективности на примере ЗШО. Показаны принципиальные направления переработки и утилизации ЗШО и пути повышения их качества как вторсырья.

Based on an analytical study of a set of patented technological solutions, a methodology for assessing the quality of ASW as an object of processing and disposal is proposed. A rationale for the feasibility of using such a methodology is given. Resource-saving technologies for waste processing that have undergone pilot and pilot testing are presented. The reasons for the feasibility of largescale involvement in the processing and disposal of technogenic raw materials concentrated in artificial accumulations of waste that pollute the environment are considered. It is noted that resource efficiency characterizes the resource-saving system in terms of the degree of waste utilization and the quality of the resulting products (while minimizing costs and environmental risks). The criteria for resource efficiency of waste and secondary raw material processing are noted: the degree of waste utilization, technological indicators of the processes used, indicators of new products, specific energy consumption. An assessment of resource efficiency is given using ASW as an example. The fundamental directions of ASW processing and disposal and ways to improve their quality as secondary raw materials are shown.
АНАЛИЗ ОТЕЧЕСТВЕННЫХ РАЗРАБОТОК МНОГОРАЗОВЫХ СТУПЕНЕЙ РАКЕТ-НОСИТЕЛЕЙ
Authors: ЛЕЖИН Д С. , НАГУРНЫЙ И О. , ЧУГУНКОВ Е В.
Published: February 2025

В данной статье представлен обзор советских и российских разработок, и текущие состояние дел. Вопрос повторного использования ступеней или всей ракеты-носителя (РН), был актуален еще в первые годы разработки ракетно-космической техники (РКТ). Повторное использование РН является одним из немногих путей в уменьшении стоимости запуска полезной нагрузки и стоимости эксплуатации изделий РКТ в целом. Многие конструкторские бюро и исследовательские институты по всему миру проводили исследования и испытания различных систем посадок. Основным вопросом при разработке многоразовых РН является выбор принципиальной схемы посадки.

This paper presents a review of Soviet and Russian developments and the current state of affairs. The issue of reuse of stages or the whole launch vehicle (LV) was relevant in the early years of space rocket technology (SRT) development. The reuse of boosters is one of the few ways to reduce the cost of launching payloads and the cost of operating RCT products in general. The main issue in the development of reusable boosters is the choice of the principle landing scheme. Many design bureaus and research institutes around the world have conducted studies and tests of various landing systems.
Introduction
Authors: Attruia Francesco , Vicari Stefano
Published: February 2025

Introduction
De quoi El Risitas est-il le mème ? Analyse sémiopragmatique
Authors: Marcoccia Michel
Published: February 2025

This study focuses on the use of the El Risitas meme in the Blabla18-25 forum and addresses three
aspects. We first proceed to a semiopragmatic analysis of the meme. By analyzing a corpus of
messages extracted from the Blabla18-25 forum, from the jeuxvideo.com website, including El Risitas
in its original or transformed forms, we take into account the following different aspects: forms (visual or
scripto-visual language), type of propagation (replication or variation) and functions of the meme. This
analysis highlights the polysemic nature of the meme and its role in the development of a community
language. We then propose a dialogical analysis to describe the function of the meme in the interactional
dynamics of exchanges. Finally, we show how the meme has become a political object, enabling its
users to express their proximity to a set of extreme-right, racist, anti-feminist or homophobic opinions.
Configurations sémiolinguistiques des discours mémétiques sur Twitter/X : traits pragmaénonciatifs et relations intersémiotiques
Authors: Cagninelli Claudia
Published: February 2025

This paper examines the technodiscursive construction of tweets that include a memetic content or have
a memetic configuration, on the topic of the first Covid-19 lockdown in France. The objective is to
analyze the enunciative and pragmatic features of the textual part of these tweets in order to observe
their impact on the (re)contextualization of memetic contents or on the structuring of “pseudo-memetic”
configurations. Two cases are analyzed: tweets containing memes, and tweets with a text-image
relationship similar to that observed in memes. The study of the different semiolinguistic configurations
that characterize these plurisemiotic productions reveals some differences in the linguistic structure and
in the pragmatic dimension of these two categories of tweets.
Innovative synergistic solvent-catalyst paradigm for sustainable allylic C–H functionalization
Authors: Wang Rui , Zhang Long , Luo Sanzhong
Published: February 2025

Achieving sustainable catalytic transformations requires synergistic optimization of solvent systems, catalytic motifs and energy inputs. Herein, we report a synergistic Pd/hydroquinone catalytic system that enables aerobic allylic C–H functions under ambient conditions (rt–50 °C, air) with high turnover frequency (TOF), using ethanol/water as a green medium. This strategy achieves unparalleled synthetic efficiency and demonstrates remarkable versatility across two pivotal transformations (alkylation and amination) involving over 90 substrates (up to 99% yield), directly aligning with China’s strategic goals for decarbonizing chemical manufacturing. It also delivers exceptional stereocontrol (up to 93% ee for quaternary stereocenters) and enables advanced allylic transformations within a green framework through additional synergistic catalysis. By integrating solvent engineering with cooperative catalysis, we have developed a scalable platform for the synthesis of FDA-certified allylic pharmaceuticals and high-value chemicals. demonstrating how molecular-level innovation can drive sustainable industrial transformation.
Theory of Field-Dependent NMR Shifts in Paramagnetic Molecules
Authors: Lang Lucas , Fiorucci Letizia , Parigi Giacomo , Luchinat Claudio , Ravera Enrico
Published: February 2025

NMR chemical shifts depend on the magnetic flux density, which becomes more and more important when stronger and stronger magnetic fields become available. Herein, we develop a theory of the field dependence of NMR shifts of paramagnetic molecules in solution. Our derivation leads to two distinct approaches: a finite field approach that describes the shift up to infinite order in the applied field B0 but requires numerical integration for the orientational average, and a 2nd order approach that is valid up to 2nd order in B0 . In this latter approach, the orientational average can be performed analytically and the field dependence cleanly separates into two additive terms: the well-known “indirect” field dependence due to incomplete averaging in solution and the “direct” field dependence due to the nonlinear response to the external field. In analogy to the diamagnetic case, the direct field dependence depends on a fourth-order tensor τ whose elements are fourth derivatives of the electronic Helmholtz free energy. Generalizing the Van den Heuvel–Soncini equation, we provide analytical sum-over-states equations for these higher-order derivatives. Using the NiSAL-HDPT complex as an example, we demonstrate the applicability of the 2nd order approach at room temperature and the highest commercially available field strength and show that it agrees well with the field dependence measured experimentally.
Growing and Linking Optimizers: Synthesis-driven Molecule Design
Authors: Descamps Clarisse , Bouttier Vincent , Sanz García Juan , Perron Quentin , Tajmouati Hamza
Published: February 2025

In the present work, two reaction-based generative models for molecular design are presented: Growing Optimizer and Linking Optimizer. These models are designed to emulate real-life chemical synthesis by sequentially selecting building blocks and simulating the reactions between them to form new compounds. By focusing on the feasibility of the generated molecules, Growing Optimizer and Linking Optimizer offer several advantages, including the ability to restrict chemistry to specific building blocks, reaction types, and synthesis pathways, a crucial requirement in drug design. Unlike text-based models, which construct molecules by iteratively forming a textual representation of the molecular structure, and graph-based models, which assemble molecules atom by atom or fragment by fragment, our approach incorporates a more comprehensive understanding of chemical knowledge, making it relevant for drug discovery projects. Comparative analysis with REINVENT 4, a state-of-the-art molecular generative model, shows that Growing Optimizer and Linking Optimizer are more likely to produce synthetically accessible molecules while reaching molecules of interest with the desired properties.
Accelerated Design of Gold Nanoparticles with Enhanced Plasmonic Performance
Authors: Montaño-Priede José Luis , Rao Anish , Sánchez-Iglesias Ana , Grzelczak Marek
Published: February 2025

Finding the optimal dimensions of metal nanoparticles to maximize their plas- monic performance in targeted applications is a complex and time-consuming process that typically requires a trial-and-error approach. Here we propose a universal pipeline that integrates Bayesian optimization with electrodynamics simulations to find optimal dimensions of gold bipyramids with superior plasmonic performance in photothermal efficiency, enhancement of Raman scattering and photoluminescence, strong coupling between plasmon and exciton, and aggregation-induced color difference. Our workflow is a straightforward tool for plasmonic nanoparticle design, setting their optimal dimensions for targeted applications.
An Assessment of drying agents for use in desiccator for teachers, undergraduate and graduates
Authors: Herbig Marcus
Published: February 2025

This article assesses various drying agents suitable for use in desiccators, aimed at teachers, undergraduates, and graduates. Desiccators are essential laboratory tools for drying solids and maintaining low humidity to prevent unwanted reactions. The choice of desiccant is critical, as they reach different residual humidity and perform the drying process with different speed. Additionally, the desiccant can react and therefore remove not only water from the gas phase inside the desiccator. This study details the structure of classical and modern desiccators, the choice of vacuum conditions, and the hazards associated with using certain desiccants. Several desiccants, including calcium chloride, copper(II) sulfate, magnesium perchlorate, and molecular sieves, and others are evaluated, discussing their properties, capacities, and safety considerations. Besides, an experimental setup for measuring humidity absorption rates and residual moisture is outlined. The findings indicate that desiccants like magnesium perchlorate and molecular sieves demonstrate low residual moisture and high absorption speeds, but have disadvantages considering regeneration or safety issues. The article concludes with recommendations for selecting appropriate desiccants based on their characteristics, and ease of use, while acknowledging the need for careful handling of hazardous materials.
Production of high-value antibiotics by Teredinibacter turnerae using paper- and plant-based waste products
Authors: Gerton Marina , Altamia Marvin , Distel Daniel , Miller Bailey , Schmidt Eric
Published: February 2025

Cellulosic materials are commonly used in the production of biofuels and commodity chemicals. Here, we employ a cellulolytic bacterium to produce high-value antibiotics using paper and plant waste material as primary feedstocks. Teredinibacter turnerae is an intracellular symbiont of shipworms, marine bivalves of the family Teredinidae, where it contributes cellulases and other carbohydrate-active enzymes that help the animals digest wood. T. turnerae is also a prolific producer of antibiotic drug leads proposed to be integral to shipworm ecology. In the presence of waste cellulose as the sole carbon source, T. turnerae robustly produced potent antiparasitic and antibiotic agents. This suggests an inexpensive strategy to harness mixed waste materials for the synthesis of high-value compounds, such as pharmaceuticals.
Reaction Network of CO₂ Hydrogenation into C1-2 Oxygenates and Its BEP Relationships
Authors: Polynski Mikhail , Kozlov Sergey
Published: February 2025

Despite many efforts to steer CO₂ hydrogenation for the synthesis of valuable chemicals, its mechanistic intricacies remain poorly understood, complicating industrial applications. In this work, we apply a novel ansatz, allowing us to construct simplified catalytic reaction networks and account for the realistic active sites on transition metal nanoparticles to analyze CO₂ hydrogenation on Cu and Pd. Moreover, we present Brønsted-Evans-Polanyi relationships tailored to transition state characteristics, enabling further machine learning-driven exploration of CO₂ hydrogenation on transition metal-based catalysts and deepening our understanding of the underlying mechanism. By assessing the kinetic viability of various reaction pathways, we highlight the outstanding properties of Cu in the catalysis of various hydrogenation and C–C coupling steps in the CO₂ hydrogenation network. Our theoretical framework addresses the intrinsic complexities of CO₂ hydrogenation, advancing our understanding of its mechanism and guiding rational catalyst design studies.
Exploring the Causes of Nonattendance at Follow-Up Visits in Diabetes Mellitus Cases
Authors: Mukta Dr. Meherunnesa , Saha Dr. Sanjoy Kumar , Ahmed Dr. Tasnim , Rahman Dr. Mohammad Atiqur , Imrul Dr. Md. Mahmudur Rahman , Akhter Dr. Arifa , mirza Dr. Nahid , Farzana Dr. Rumana , Rahman Dr. Jarin
Published: February 2025

Background:

Diabetes mellitus is said to be an emerging health epidemic, especially within the developed world, that cannot be treated without lifelong medical supervision through clinical reviews. Failure by patients to observe these appointments greatly hinders the management of diabetes due to a number of socioeconomic, psychological, and systemic factors.

Objective:

This paper focuses on identifying factors associated with nonadherence to follow-up visits of diabetes patients attending Basundhara Ad-Din Medical College Hospital in Dhaka, Bangladesh.

Methods:

A cross-sectional self-administered questionnaire survey was carried out between January 2023 and January 2024, using a systematic random sampling technique targeting 100 diagnosed diabetes patients. The Questionnaire data collection aimed at sociodemographic and clinical characteristics, history of follow-up appointments attendance, perceived barriers to follow-up medical attendance, and patients’ perceptions around the issue. In the study, ethical clearance was sought and obtained while informed consent was received from the participants.

Results:

The findings revealed that 80% of participants missed followup visits, with key reasons including lack of time (35%), insufficient awareness about follow-up importance (18%), long wait times (15%), and financial constraints (13%). Although 59% felt their concerns were adequately addressed by healthcare providers, only 10% utilized telehealth services, indicating limited access to alternative care options.

Conclusion:

This study highlights key gaps in diabetes care in Bangladesh and emphasizes patient-focused solutions. Proposed improvements include better patient education, enhanced healthcare facilities, and expanded telemedicine options. These changes aim to improve diabetes treatment, control, and patient involvement.
PENGEMBANGAN APLIKASI LIVEWORKSHEETS UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA KELAS IX MATERI PERPANGKATAN DAN BENTUK AKAR
Authors: Rozid Abd , Rufi'i Rufi'i , Rohman Ujang
Published: February 2025

Penelitian ini bertujuan untuk mengembangkan media cetak lembar kerja peserta didik menjadi media yang interaktif berupa elektronik lembar kerja peserta didik (E-LKPD) berbantuan aplikasi web Liveworksheets pada materi bilangan berpangkat dan bentuk akar. Metode penelitian yang digunakan adalah metode Research and Development (RD) dengam model ADDIE yang teridiri dari beberapa tahap: (1) Analisis (analyze), (2) Perencanaan (design), (3) Pengembangan (development), (4) Penerapan (implementation), (5) Penilaian (evaluation). Hasil analisis dari ahli media memperoleh persentase Hasil analisis data dari validasi ahli media memperoleh persentase sebesar 91,07% dengan kriteria sangat valid dan hasil analisis data dari ahli materi memperoleh persentase sebesar 92,08% dengan kriteria sangat valid. Hasil analisis data angket respon siswa memperoleh skor rata-rata dari tiga aspek meliputi; (1) aspek isi materi sajian memperoleh 91%, (2) aspek kemudana 92%, (3) aspek kejelasan pesan yang disampaikan 91%. Sehingga dapat disimpulkan bahwa media E-LKPD berbasis aplikasi liveworksheets yang dikembangkan memperoleh kategori “sangat menarik”. Dengan demikian media E-LKPD yang dikembangkan melalui aplikasi liveworksheets sangat layak untuk digunakan dalam proses pembelajaran.
Penerapan Asas-Asas Umum Pemerintahan Yang Baik Dalam Pemberhentian Tidak Dengan Hormat Terhadap Anggota Polri
Authors: Maulidin Maulidin , Gani Iskandar A. , Efendi Efendi
Published: February 2025

This study aims to analyze one form of government action is the imposition of Dishonorable Dismissal (PTDH) sanctions against members of the National Police. There are legal problems when in practice the imposition of PTDH sanctions against members of the Indonesian National Police within the Aceh Regional Police raises problems with their compliance with laws and regulations and the general principles of good governance (AUPB). This study uses a normative juridical method, with a statutory approach, a concept approach, and a case approach. This study also uses empirical juridical methods with a socio-legal approach. The results of the study confirm that the Sanctions of Dishonorable Dismissal (PTDH) against members of the Indonesian National Police by authorized officials have not implemented the General Principles of Good Governance (AUPB). This also includes several principles in good governance that have not been implemented including the principle of legal certainty, the principle of balance, the principle of accuracy, and the principle of impartiality.
Effects of Irregular Bathymetry on the Performance and Wake Characteristics of Tidal Stream Turbines: A Case Study of a Tidal Power Site
Authors: Mwero Ngome , Fu Song , Inamitsu Takafumi , Ordonez-Sanchez Stephanie , Mwangi Benson , Garcia-Novo Patxi , Johnstone Cameron , Sakaguchi Daisaku
Published: February 2025

Tidal energy has emerged as a promising renewable energy source, with abundant marine resources available in many parts of the world. To exploit this resource efficiently, reliable and computationally efficient methods are required to analyze energy yields from tidal arrays in real sites worldwide. This paper investigates the impact of irregular-bathymetry seabed elements near a tidal turbine location on the turbine’s performance and wake. A high-resolution three-dimensional bathymetry model was created, and full-scale unsteady simulations were performed using the ANSYS-Fluent computational fluid dynamics tool and the Shear Stress Turbulence (SST) model for two cases: one with the site bathymetry and one with a flat seabed. Compared to the flatbed case, the results show a 1.84% increase in the average turbine power output for the site-bathymetry case. A 4.1% increase in average wake recovery rate was observed near the hill-like seabed features from 3D to 7D downstream from the turbine, followed by 11% reduction in wake recovery rate over the bathymetry slope from 9D downstream from the turbine. The findings of this study highlight the implications of bathymetry-generated effects in optimal site selection and tidal energy farm design.
Safety evaluation of an extension of use of the food enzyme triacylglycerol lipase from the genetically modified Trichoderma reesei strain RF10625
Authors:   EFSA Panel on Food Enzymes (FEZ), Zorn Holger , Barat Baviera José Manuel , Bolognesi Claudia , Catania Francesco , Gadermaier Gabriele , Greiner Ralf , Mayo Baltasar , Mortensen Alicja , Roos Yrjö Henrik , Solano Marize L. M. , Sramkova Monika , Van Loveren Henk , Vernis Laurence , Cavanna Daniele , de Nijs Roos Anna , Di Piazza Giulio , Liu Yi
Published: February 2025

Abstract
The food enzyme triacylglycerol lipase (triacylglycerol acylhydrolase; EC 3.1.1.3) is produced with the genetically modified Trichoderma reesei strain RF10625 by AB Enzymes GmbH. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in two food manufacturing processes. Subsequently, the applicant has requested to extend its use to include three additional processes. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of five food manufacturing processes. As the food enzyme–total organic solids (TOS) are removed from the final foods in one food manufacturing process, the dietary exposure to the food enzyme–TOS was estimated only for the remaining four processes. It was calculated to be up to 0.197 mg TOS/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level previously reported (1000 mg TOS/kg bw per day, the highest dose tested), the Panel derived a margin of exposure of at least 5076. Based on the new data, the revised margin of exposure and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.
Safety evaluation of an extension of use of the food enzyme non‐reducing end α‐l‐arabinofuranosidase from the non‐genetically modified Aspergillus tubingensis strain ARF
Authors:   EFSA Panel on Food Enzymes (FEZ), Zorn Holger , Barat Baviera José Manuel , Bolognesi Claudia , Catania Francesco , Gadermaier Gabriele , Greiner Ralf , Mayo Baltasar , Mortensen Alicja , Roos Yrjö Henrik , Solano Marize L. M. , Sramkova Monika , Van Loveren Henk , Vernis Laurence , Sanmartín Laura , Liu Yi
Published: February 2025

Abstract
The food enzyme non‐reducing end α‐l‐arabinofuranosidase (α‐l‐arabinofura‑noside non‐reducing end α‐l‐arabinofuranosidase, EC 3.2.1.55) is produced with the non‐genetically modified Aspergillus tubingensis strain ARF by DSM Food Specialties B.V. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in five food manufacturing processes. Subsequently, the applicant requested to extend its use to include two additional processes. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of seven food manufacturing processes. The dietary exposure was calculated to be up to 0.458 mg total organic solids (TOS)/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level previously reported (234 mg TOS/kg bw per day, the highest dose tested), the Panel derived a margin of exposure of at least 511. Based on the new data, the revised margin of exposure and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.
Critical appraisal tool (CAT) for the evaluation of evidence from animal observational epidemiological studies
Authors: Hornbacher Anselm , Greiner Matthias , Müller‐Graf Christine , Ghoreishi Narges
Published: February 2025

Abstract
Risk of bias assessments in animal observational epidemiological studies can be challenging due to the heterogeneity in observational study designs and the lack of available tools for guided approaches. We modified the structure of the previously developed tool for observational human studies, making it applicable to animal observational epidemiological studies and allowing researchers to conduct a systematic, comprehensive, standardized evaluation of the risk of bias in animal observational epidemiological studies. The prototype tool development was following a three‐stage consensus‐building approach: 1) defining the scope and overall structure of the tool. 2) articulating the wording of domains and items and their signalling questions. 3) finalising the tool with a test round to ensure its reliability and user‐friendliness. Each stage consisted of a Delphi‐round followed by an online consensus group meeting in a panel of experts. We engaged a total of 13 experts from different areas of veterinary epidemiology, tool development, and reproducible research methodology. The modified Delphi study allowed the consensus‐based development of the tool. Seven experts tested the prototype in a pilot study. The tool was then programmed as a web app and its usability was determined. Results from the test phase were then implemented into a final version of the prototype tool. The raRoB‐vet tool was developed for evaluation of animal observational studies to allow for standardized and reproducible assessment of risk of bias. It contributes to fill the existing gap in critical appraisal tools in epidemiological animal studies. The tool is currently considered a prototype tool that will benefit from further testing of its feasibility, validity, reliability, reproducibility and fitness for specific purposes.
FFRAUD‐ER: Development of a computational model for identifying Food Fraud incidents as drivers for Food Safety Emerging Risks
Authors: Aristodemou G. , Braun A. , Frangos A. , Papadopoulos A. , Vrachimis V.
Published: February 2025

Abstract
The primary objective of this project was the development of a computational model aimed at identifying food fraud incidents as drivers for food safety emerging risks, in alignment with EFSA's activities on environmental scanning. These activities include the identification and analysis of emerging risks, the enhancement of risk identification methodologies, and the communication of identified risks. At first stage, the focus was on the identification and prioritisation of data sources of historical food fraud cases. This phase involved rigorous criteria for data selection to ensure accuracy and relevance. Subsequently, a labelled dataset was developed through systematic data categorisation and annotation, essential for training the computational model to detect patterns of potential safety risks in food fraud incidents. The core of the project involved the creation of the Computational Model (CM) using natural language processing (NLP) and deep learning algorithms. Six state‐of‐the‐art NLP models (BERT, XLNet, GPT‐3, ELECTRA, T5, and ELMo) were identified, trained and tested on the labelled dataset, with XLNet achieving an F1‐Score of 95% and a ROC/AUC Score of 98%. An iterative refinement phase followed, involving feedback from the FFRAUD‐ER Network and stakeholders to enhance the model's reliability. Finally, the model's application in real‐world scenarios was explored, demonstrating its utility in aiding EFSA and other Emerging Risk Identification networks to detect emerging food safety risks. The results indicate that the computational model can successfully determine whether a food fraud instance poses a food safety risk. Statistical and analytical techniques applied alongside the CM on newly acquired data of food fraud incidents have shown potential, although their efficiency and effectiveness will primarily depend on the quality and quantity of future data.
Exploring the Identity Lab: The Immigrant Perspective in Jasmine by Bharti Mukherjee
Authors: Bundela Varsha Raja , Saxena Rashmi
Published: February 2025

The paper analyzes key themes such as cultural hybridity, gender dynamics, and personal empowerment, illustrating how Jasmine navigates patriarchal constraints, societal expectations, and the trauma of migration. Mukherjee critiques traditional notions of static identity, instead presenting it as a continuous process of negotiation shaped by external pressures and internal aspirations. The immigrant experience, as portrayed in Jasmine, is both a challenge and an opportunity for reinvention, highlighting the protagonist’s ability to reconstruct her identity in response to new cultural contexts. By situating Jasmine’s narrative within the broader discourse of diasporic literature and feminist theory, this study underscores the transformative potential of migration and the resilience of individuals navigating cultural dislocation. Mukherjee’s Jasmine emerges as a powerful exploration of the immigrant experience, offering insights into the universal quest for belonging and self-actualization in a globalized world. This research contributes to the understanding of identity formation and cultural integration, emphasizing the enduring relevance of Mukherjee’s work in contemporary literary and social studies.
RESEARCH ON ENGLISH TEACHING REFORM IN HIGHER VOCATIONAL COLLEGES BASED ON NATIONAL VOCATIONAL COLLEGE ENGLISH SPEAKING CONTEST
Authors: Li Mingjun , Long Zhiyong , He Yan
Published: February 2025

The National Vocational College English Speaking Contest has been playing a leading role in the English teaching reform in higher vocational colleges in China. The Contest mainly consists of five sections, i.e. Presentation, Interview, Debate, Role-Play and Speech. By analyzing each section, it is clearly shown that the competencies examined in the Contest align closely with that of the English teaching reform. However, the problems exposed by the contestants also deserve our attention, which helps identify the challenges in current higher vocational English teaching, including weak English foundation, insufficient communication awareness, limited critical thinking ability, inability to adapt effectively in real-time, etc. Combining the positive effects the Contest brings and the problems the contestants exposed, the article suggests updating teaching philosophies, improving teaching methods, expanding teaching resources and optimizing teaching assessments to promote higher vocational English teaching reform.
FORMAL AND INFORMAL WOMEN WORKERS: A SYSTEMATIC BIBLIOMETRIC EXPLORATION AND VISUALIZATION OF RESEARCH TRENDS AND THEMES
Authors: George Tessymol , Vipin Chandran K P
Published: February 2025

This bibliometric analysis explores the research landscape on formal and informal women workers, who engage in organized, regulated employment or unorganized, unregulated sectors, respectively, each characterized by differing levels of job security, social protection, and working conditions. The study employs Biblioshiny and VOSviewer software, using data from the Scopus bibliographic database, to map the academic progress in this domain. The analysis examines Annual Scientific Production, revealing trends in scholarly output over time, and identifies the most relevant authors and sources shaping this field. Geographical insights are provided through an evaluation of countries’ scientific production and co-authorship networks, emphasizing the global distribution of research efforts. Trend topics showcase the evolution of thematic priorities, while the thematic map highlights central and emerging themes in the literature. Bibliographic coupling of documents uncovers intellectual connections between studies, and keyword co-occurrence analysis sheds light on the conceptual framework of the field. The study also investigates collaboration patterns, with a focus on co-authorship at the country level, offering insights into international partnerships. The findings provide a nuanced understanding of the research priorities and gaps in the study of formal and informal women workers. These insights aim to inform policymakers and researchers, facilitating targeted strategies for addressing issues faced by women in both employment sectors.
EVALUATING IMAGE SEGMENTATION TECHNIQUES: A COMPARATIVE APPROACH
Authors: K.V Shaheena , Dhanalakshmi S
Published: February 2025

Image segmentation plays a crucial role in image analysis, computer vision, and pattern recognition. It involves partitioning an image into meaningful regions to facilitate further analysis. Various segmentation techniques exist, including threshold-based methods, edge detection algorithms, region-based approaches, clustering techniques, and deep learning-based segmentation. This paper presents an overview of different segmentation methods, their comparative analysis, and practical implementation in Python.
Resistive switching mechanisms in memristor structures based on nonstoichiometric silicon nitride layers
Authors: Romanov I. A. , Kovalchuk N. S. , Vlasukova L. A. , Parkhomenko I. N. , Komarov F. F. , Demidovich S. A.
Published: February 2025

The electrophysical properties and the resistive switching effect of the Ni/SiNx/p+Si/Ni memristor structure are investigated. Silicon nitride films with a thickness of ~40–60 nm were deposited in inductively coupled plasma from a SiH4– N2–Ar mixture at [SiH4]/[N2] ratios of 2.19 and 2.55, which ensured the formation of SiNx with an excess of Si compared to stoichiometry. To investigate the effect of thermal annealing on the resistive properties of SiNx, one of the wafers with a nitride film was annealed using rapid thermal annealing (RTA, 1200 °C, 3 minutes in Ar). The resistive switching effect was observed when applying a voltage from −4 to +10 V for test structures based on nitride films with refractive indices of 2.34 and 2.5. It is shown that the conductivity and charge transport mechanism in SiNx films with resistive properties depend on the deposition conditions and subsequent heat treatment. Possible mechanisms of resistive switching are discussed.
Synthesis of 2-alkyl-substituted isoflavonoid analogues with non-aromatic ring A on the basis of 2-[2-(aryl)acetyl]cyclohexane-1,3-diones and carboxylic acid anhydrides
Authors: Pashkovsky F. S. , Rubinov D. B. , Linnik V. I. , Lakhvich F. A.
Published: February 2025

A simple and convenient method for the synthesis of 2-alkyl-substituted analogues of isoflavonoids with nonaromatic ring A is proposed. The method consists of acylation of 2-[2-(aryl)acetyl]cyclohexane-1,3-diones with carboxylic acid anhydrides followed by intramolecular aldol-crotonic condensation of the resulting enolacylates in the presence of basic agents (triethylamine, sodium acetate, potassium carbonate). 2-[2-(Aryl)acetyl]cyclohexane-1,3-diones were obtained by condensation of 5-substituted cyclohexane-1,3-diones with arylacetic acids under the action of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine-catalyzed O-C isomerization of the resulting O-acylates.
. Zoning of the Central Belarus area by the degree of comfortability of the geological environment for the people’s life
Authors: Matveyev A. V. , Kukharik E. A. , Glaz A. S.
Published: February 2025

A zoning scheme (in points) of the Central Belarus area by the degree of comfortability of the geological environment for the people’s life was constructed. It was based on the analysis of maps and diagrams of modern geological processes, literature, field work materials and stationary observations. The following types of territories were identified: comfortable (less than 30 points), moderately comfortable (30–50 points), low comfort (50–70 points), uncomfortable (more than 70 points) and uncomfortable in active fault zones (more than 70 points). It was established that the degree of comfort correlates with the features of the earth’s surface relief, the probability and intensity of modern geological processes.