bluuebunny/crossref_metadata_2025 huggingface dataset:
CREATING ROOFS WITH THE HELP OF THE CONCEPTUAL MODELING IN REVIT
Authors: Khusainova Galina Vladimirovna , Khusainov Damir Zinnurovich
Published: November 2022

In the article is considered various variants of creating roof (one from basic elements of architectural design) with the help of conceptual forms in graphic programme Autodesk Revit
COOLING OF AN INFINITE RECTANGULAR PLATE UNDER BOUNDARY CONDITIONS OF THE SECOND AND THIRD KIND
Authors: Kanareykin A. I.
Published: November 2022

In this article, the question of finding the law of the change of the temperature field from time in a rectangular plate under different boundary conditions set on the walls of the plate is considered. At the same time, the task itself is non-stationary. In this paper, based on the Fourier method, a solution for the distribution of the temperature field in a plate of infinite length is obtained. The solution itself is obtained in the form of a series containing trigonometric and exponential functions. Special cases were also considered. The reliability of the obtained result is confirmed by the fact that one of the special cases leads the problem to a problem with boundary conditions of the first kind, when the temperature of the surface is constant.
Resolving disputes with an healing effect: the practice of mediation in India
Authors:   Nalsar Unversity of Law, Chakraborty Anirban , Sarker Shuvro ,   Indian Institute of Technology
Published: November 2022

This paper has traced the background and evolution of mediation movement in India. Discussing about the beginning of the advocacy for ADR and mediation in the late 1990, how the mediation movement has gained momentum in past two decades. It is pertinent to note the policy and legislative introduced to popularize mediation and encourage its adoption. Also, the statistical data presented from various sources reflects about the efforts undertaken towards augmenting appropriate infrastructural and human resource to strengthen its ecosystem. However, the brightness of these development must not blindfold us to ignore about the gaps that still exist. Unless these gaps are addressed the future of mediation will remain uncertain.
Future of Dispute Resolution and Investment in BRICS
Authors:   Hamdard Institute of Legal Studies, Fatima Naazish
Published: November 2022

The BRICS is a term which refers to the group of Five Nations - namely, Brazil, Russia, India China and South Africa. They are touted to be emerging economies and hold an annual BRICS summit to commemorate their partnership and further their growth. One of the crucial components for their growth is investment within the BRICS Nations. This is aimed at the promotion of an equitable international economic order and expediting the growth of the BRICS nations. The dispute settlement mechanism is the key to establishing a stable and progressive investment regime. The countries of BRICS are culturally different and have different legal systems. This also leads to a varied regime of investment protection. In the 2014 annual summit, the Ministries of External Relations of the BRICS nations agreed to build a common approach to improve the investment agreement and improve their dispute settlement mechanism. The paper analyses the existing investment regime, legal systems of the BRICS nations and provides suggestions as to how the dispute settlement mechanism can further be amended and applied for encouraging investment and promoting economic growth.
Implementation and Obstacle of Reward and Punishment at Pesantren Al-Azhar-Gresik
Authors: Hadiyansyah Dhuha
Published: November 2022

This paper is a case study that aims to take a closer look at how punishments and rewards are implemented at the Al-Azhar Islamic Boarding School and what the obstacles are in both male and female dormitories. The data obtained through observation and in-depth interviews. This study found that the Islamic boarding schools have four categories of rules that if violated, the perpetrators will be sanctioned, namely ritual, cleanliness, behavior, and security. The form of punishment is graded ranging from verbal reprimand to being fired from the pesantren or even the formal school. Meanwhile, there are a number of obstacles in the application of rewards and punishment, namely: inconsistency, unilateral rules, lack of knowledge of child psychology, minimal facilities and infrastructure, and imbalance between rewards and punishments
How does Credit Unions’ accountability affect their performance and mission achievement? Multiple-case studies of credit unions in Indonesia
Authors:   , Sumarwan Antonius
Published: November 2022

This research investigates factors influencing accountability practices and their effects, specifically on performance and mission achievement in six Indonesian credit unions. Developing a skeletal inputs-processes-outputs framework enriched by concepts from strong structuration theory, this study employed a multiple-case study approach. Findings show that the credit unions’ accountability practices were predominantly influenced by their conjuncturally specific internal structures, with implications for credit union management’s levels of agency. Two types of accountability practices were identified (i.e., basic and comprehensive). The positive effects of the credit unions’ accountability practices included trust, participation, collective responsibility, personal, organisational development, and enhanced performance and mission achievement.
Development and analysis of wireless power transfer communication systems for left Ventricular Assist Devices
Authors:   , Pathmanathan Shaetrun
Published: November 2022

Where Ventricular Assist Devices show great promise in extending human life, relying on a driveline piercing the human body makes this unattractive. Wireless Power Transfer replaces this but requires an effective wireless implant feedback system. This project explores the development of an inductive power transfer assistive communication system, considering the implant environment’s delaying effect on time critical feedback communications. Experimental measurements of this delayed feedback loop were simulated with, to verify its effect on the wireless power transfer system, producing the results in this study. An improvement to the wireless power transfer control system is suggested to compensate for this.
Out-of-field dosimetry in contemporary radiation therapy
Authors:   , Peet Samuel
Published: November 2022

Radiation therapy is a beneficial treatment for approximately half of all people diagnosed with cancer. This project improved the safety of radiation therapy for several vulnerable cohorts: pregnant patients, patients with electronic implants such as pacemakers, and young people at risk of developing secondary cancers later in life. In doing so, this research furthered equitable access to safe, high-quality health care.
Internalization of Islamic Values Through Pesantren Ramadhan Activities (Case Study In MAN Bondowoso, East Java)
Authors: Maula Atika Rofiqatul , Fathani Sahrizal
Published: November 2022

Pesantren Ramadan activities are a series of activities in the form of deepening Islamic values, both in terms of worship and in behavior. One of the institutions that carry out this activity is MAN Bondowoso, where the activity is carried out offline. The purpose of this article is to find out the concept applied by MAN Bondowoso in carrying out the Pesantren Ramadan (PESROM), as well as the values instilled in it. This research is qualitative research, that is, data sources obtained through documents and interviews online. The results of this study showed that the material delivered when PESROM was about the fikih of worship and the realization of Islamic values in the form of discipline, spirit of worship, noble character and religious moderation.
PENINGKATAN KETERAMPILAN MEMBACA MENULIS PERMULAAN MENGGUNAKAN MODEL VISUAL, AUDITORY, READ WRITE, KINESTHETIC DI KELAS II SD N 82/II DUSUN PANJANG
Authors: Guswita Reni
Published: November 2022

This research is a classroom action research, which consists of two cycles. Each cycle consists of planning activities, implementing actions, observing and reflecting. Data collection techniques in this study were observation, tests and documentation. The research subjects were 1 educator and 22 students. The results of this study showed the teaching learning process, the first meeting of the first cycle was 77%, the second meeting of the first cycle was 80%, the first meeting of the second cycle was 90%, the second meeting of the second cycle was 95.45%. Observation of students during the learning process in the first cycle of the first cycle of good category is still 0%, the second meeting of the cycle increased to 54%. Furthermore, the first meeting in the second cycle in the category increased to 77% and the second meeting in the second cycle in the good category increased to 91% which was said to be successful. The results of the initial reading and writing skills assessment of students in cycle I were in the good category of 12 people or 54%. In cycle II the good category increased to 20 people or 91% and was declared successful. Based on the results of this study, it can be concluded that the use of Visual, Auditory, Read Write, Kinesthetic models can improve students' initial reading and writing skills in class II.
PENINGKATAN KEAKTIFAN DAN PRESTASI BELAJAR MATEMATIKA MELALUI GOOGLE MEET BERBANTUAN JAMBOARD DAN PENTABLET
Authors: Zubaidah Ida
Published: November 2022

This Best Practice is motivated by the lack of activeness and learning achievements of students in online learning activities during the COVID-19 pandemic. This study is focused on efforts to enhance students' activeness and learning achievement in mathematics through Google Meet assisted by jamboard and pentablet applications. The subjects of this study were students of class VIII D of SMP Negeri 41 Semarang with a total of 32 people. Based on an analysis of the observations results during the study, student learning achievement shows an improvement, as evidenced by an increase in student activity scores compared to the results before using Google Meet assisted by Jamboard and Pentablet applications. Students learning activeness increased to 81.250%. In addition, the achievement of the minimum criteria of mastery learning percentage has increased, before this study by 56.25%, increasing to 84.375%. It can be concluded that online learning through Google Meet assisted by Jamboard and Pentablet applications can enhance student activeness and learning achievement.
أهل البيت (عليهم السلام) في الشعر العراقي في القرن السابع الهجري منطلقات وتطبيقات
Authors: علي جنان
Published: November 2022

Talking about Ahl al-Bayt () and introducing them to what they encountered is a necessary matter, since every action and statement about them contains wisdom, exhortations, lessons and lessons, and that the love of God and the greatest love of His Messenger Muhammad  and the love of Ahl al-Bayt ) is a missionary principle that includes important dimensions of faith and righteous deeds. It is self-evident that the love of Ahl al-Bayt () is coupled with the love of God and His Messenger (), and it is certain that talking about their biography () in this study we cannot fulfill its right to mention their virtues and virtues, and their greatness, since all the virtues of the prophets have been met. They gathered (), so the blessings that swept the world spread through them (), and whoever loved them loved God and His Messenger, and whoever fought them has fought God and His Messenger, and that they are the successors of a prophet who shook the roots of thought in man and leaped with him over generations, the Commander of the Faithful Ali bin Abi Talib (), the Prophet’s brother and cousin, and his pure and friendly daughter Fatima () and her children, the pure imams (), represented their lives as an extension of the message of prophecy, as they counted one of its pillars that cannot understand the history of the message without understanding their history, hence this study came Tagged (Ahl al-Bayt (( in Iraqi poetry in the seventh century AH, starting points and applications), it included This study is an introduction, and several topics we mention, including: the spiritual connection to Ahl al-Bayt (), the effect of education on behavior assessment, Fadak in poetry, Al-Zahra’s sciences (). Then, this study was supplemented with a list of sources and references
EFFECTIVENESS OF EXERCISE PROGRAMS FOR SYMPTOMATIC LUMBAR SPINAL STENOSIS: A SYSTEMATIC REVIEW
Authors: Plaskan Katja , Vodičar Miha , Pajek Maja
Published: November 2022

Patients with lumbar spinal stenosis (LSS) have significant disability and functional limitations of walking. They commonly report problems with balance, sensory loss, and weakness of the muscles of the lower extremities. The prevalence and economic burden associated with LSS are expected to increase dramatically because of the aging population. Recently, physical exercise and walking programs have been presented as possible interventions to improve daily life in patients with lumbar spinal stenosis (LSS). To date, there is a lack of clear descriptions of non-surgical treatment protocols and how combinig these interventions affect daily life of the patients and help to prolong the time to surgery. The aim of this systematic review is to provide a comprehensive and updated summary to the reader addresing exercise programs which can help reduce symptoms of lumbar spinal stenosis. Two electronic databases were searched for randomized controlled studies of physical exercise or walking programs and other non-surgical treatment that examined effects on physical abilities/performance in daily life. Four articles were included. All included studies used physical exercise as an intervention, with one study also including medical care (tablet-based with the option of epidural steroid injections). Two studies included manual therapy and two studies offered individually supervised exercise sessions. As a control group, two included a home-based intervention and one was comparing three different conservative treatments included manual therapy/individualized exercise. A significant intervention effect was observed in all studies compared with the control groups, except in study, where the primary outcomes were between-group differences. The present systematic review on non-operative treatment included patients diagnosed for lumbar spinal stenosis with neurogenic claudication concluded that there is moderate-quality evidence and limiting the ability to make conclusions about their effectiveness. Further trials are needed.
THE INFLUENCE OF HAND GUARDS ON EXPLOSIVE FORCE AND PAIN AND EXERTION PERCEPTION IN A HANG HOLDING TASK
Authors: Júnior Jorge Luiz Novaes Santos , Passos Rívia da Silva , Oliveira Alinne Alves , Silva Jonas R. Dias da , Souza Ramon Silva , Passos Rafael da Silva , Machado Marco , Koch Alexander J. , Pereira Rafael
Published: November 2022

We investigated whether hand guards (HG) influence the perception of pain and exertion during the execution of a standardized task on high bar to induce forearm muscle fatigue as well as a decline in grip strength after the task. Design: A cross-over study design was employed 15 healthy and physically active volunteers completed static bodyweight holds (8 cycles of 20 second load in hang and 10 second rest), on a high bar. The exercise protocol was performed with and without HG. Perception of pain and exertion during the task were recorded. Peak handgrip force and explosive force parameters (i.e., rate of force development [RFD] and contractile impulse [CI] at 30 to 200 ms) were obtained from force-time curves. Peak force and explosive force parameters were normalized (i.e., POS/PRE) for statistical analysis. The use of a HG significantly attenuates pain perception (p < 0.05), with a moderate to large effect size (d = 0.52), but did not alter the perception of exertion during the task, nor did it alter peak force, RFD, or CI. The use of HG reduces the perception of local pain during static holds. However, HG do not alter the perception of exertion during the task nor do they alter the gripping force ability immediately afterwards. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Processing of beef rumen with ultrasonic waves
Authors: Kenenbai Gulmira Serikbayevna , Chomanov Urishbai Chomanovich , Omirzhanova Bakytzhan Bolatovna , Tatieva Amina Nurlanovna , Kassymbek Rabiga , Zhumaliyeva Gulzhan
Published: November 2022

The article discusses the main trends in processing animal products, the development of technologies to improve their quality and technologies to preserve the quality indicators of the product over time. A review of the effects of ultrasound treatment on beef rumen is presented, and the main directions of ultrasound application are determined. The advantages of ultrasonic processing and its influence on the characteristics of raw meat were researched. The modes and parameters (frequency, intensity and duration) of ultrasound treatment of muscle tissue were established based on the results. This study evaluated the effect of ultrasound treatment on beef rumen's physical, microstructural and organoleptic characteristics. The physicochemical, mineral, microbiological, vitamin and amino acid composition of beef rumen and reticulum were also studied. Based on the results of the presented review, it can be concluded that the development of technologies for processing beef rumen with ultrasound is of potential interest. The optimal parameters are 400 and 600 W/m2, with a frequency of 40 kHz, for 50-60 minutes.
ANALISIS PERAWATAN MESIN CHAIN SCRAPER CONVEYOR DI PT. CEMINDO GEMILANG BAYAH
Authors: Rijal Maulana Ihsan , Putra Ananda Yhuto Wibisono , Raihan Revkananda Arkan
Published: November 2022

Teknologi pada abad 21 memiliki peran yang penting dalam perubahan hidup manusia, salah satu perubahan tersebut yaitu penggunaan mesin-mesin yang mulai menggantikan peranan manusia, sebagai contoh peranan manusia yang digantikan oleh mesin adalah perpindahan barang. Konveyor menjadi salah satu mesin yang umum digunakan dalam memindahkan barang dari satu tempat ke tempat yang lain, konveyor terdapat berbagai jenis seperti belt conveyor, chain conveyor, roller conveyor dan lainnya. Di PT. Cemindo Gemilang Bayah mesin konveyor yang dipakai adalah chain scraper yang digunakan untuk mengangkut material berupa fly ash dari boiler menuju clingker silo. Kerusakan merupakan hal yang lumrah terjadi padi mesin, untuk mencegah hal tersebut maka hal yang harus dilakukan adalah melakukan perawatan pada mesin tersebut. Perawatan adalah suatu perpaduan dari serangkaian kegiatan yang bertujuan untuk mengelola dan memperbaiki mesin agar terjamin kesiapan operasionalnya. Tujuan penelitian ini yaitu untuk mengetahui perawatan preventif pada mesin chain scraper di PT. Cemindo Gemilang Bayah. Penelitian dilaksanakan dengan pendekatan kualitatif, yang hasilnya dianalisis secara deskriptif kualitatif. Teknik pengumpulan data menggunakan observasi, wawancara, dan studi literatur. Dengan hasil pembahasannya yaitu perawatan yang dilakukan terhadap mesin chain scraper meliputi perawatan pencegahan dan perawatan korektif. Pada perawatan preventif dilakukan tindakan adjusment pada chain dengan cara mengencangkan spring, cleaning pada bagian rotary feeder dengan cara dibersihkan menggunakan linggis atau benda panjang lainnya. dan inspection pada gearbox  dengan cara mengkur vibrasi pada gearbox serta melakukan pelumasan pada bearing, sedangkan pada perawatan korektif dilakukan tindakan replacement untuk komponen seperti teflon rod, rubber kopling, spring, bearing, chain, casing, dan reparation pada casing chain scraper dengan cara melakukan penambalan menggunakan silikon dan las.
EVALUATION OF SIMULATION EXERCISE AND DRILLS IN RESPONSE TO COVID-19 IN PAKISTAN
Authors:   Health Services Academy Islamabad, Idrees Fahmeeda , Rehman Adeela ,   Fatima Jinnah University, Rawalpindi Pakistan, Ahmad Saeed ,   TEPHINET, Islamabad Pakistan
Published: November 2022

An evidence-based assessment for the monitoring, testing, and development of functional capacity to respond to outbreaks and public health emergencies is provided through simulation exercises, which are training and quality assurance tools. It is crucial for creating and using preparedness and response capabilities at different levels like national, regional, community, and global. The disease COVID-19 is brought on by a new corona virus strain that affect the humans through zoonotic transmission. To prepare Pakistan in advance for this emergency a simulation exercise needed to occur. Keeping in view the guidelines of International Health Regulations (IHR), a proactive approach is adopted by National Institute of Health (NIH) to counter the spread of Covid-19 in Pakistan. As a part of this response plan, a functional simulation exercise is planned in Pakistan on January 29, 2020 and onwards. The exercise is developed and implemented by National Institute of Health Islamabad Pakistan as per W.H.O guidelines. Capacity building of workforce (including health workforce) for timely detection, prevention and response to covid-19on all point of entries in Pakistan. Method: In this quantitative study, 200 participants were included from airports and point of entries. A validated questionnaire was sent online. Results: Majority of employees had been provided PPE’s and they faced certain challenges in performing their duty regarding COVID 19. Results Participants were mainly satisfied with the training provided and the realistic scenario. The findings of the study also highlighted that all respondents obtained simulating exercise regarding Thermal screening of travelers, Triage, Shifting of suspected cases to hospitals, Infection prevention & control (IPC). Conclusion: Simulation exercise proved beneficial to upgrade the skills of staff to interact with the passenger by adopting all safety well. Keywords: Simulation exercise, Point of entries, Covid-19
IMAGE SCHEMA OF DEATH IN DONNE’S POETRY: A COGNITIVE PERSPECTIVE SYNONYMOUS WITH MONOTHEISTIC NOTION OF RESURRECTION
Authors:   Riphah Institute of Language & Literature, Riphah International University, Lahore Campus Pakistan, Hassan Afsheen , Ahmed Husnat ,   Riphah Institute of Language & Literature, Riphah International University, Lahore Campus Pakistan, Saleem Sumaira ,   COMSATS University, Lahore
Published: November 2022

The aim of this paper is to analyze Donne’s conceits which are delineated as metaphors by Law (2011, p. 3) in the light of conceptual metaphor theory proposed by Lakoff and Johnson (1980) to gauge what aspects of cognitive linguistics are applicable to Donne’s metaphors. For this purpose, the choice of all-pervasive concept in his poetry has been discussed as an image schema of death. Its various conceptual facets have been explored to find the variety of conceptual metaphors used by Donne to establish the single construal of death. The most conclusive point; however, was to find out if this image schema of death is far from conventional and be liable to fit into Monotheist notion of resurrection elucidated by Abdullah and Lutfi (2019, p. 86). Keywords: Cognitive linguistics, conceptual metaphor theory, image schemas, conceptual blending, Monotheistic notion of death and resurrection.
FROM DHIMMAH TO DHIMMITUDE: A THEORETICAL ANALYSIS OF THE INTERPRETATIONS AND MODELS OF THE INCLUSION OF NON-MUSLIMS UNDER AN ISLAMIC STATE
Authors:   Department of comparative Religions, Faculty of Ususluddin (Islamic studies) International Islamic University Islamabad Pakistan, Batool Munazza
Published: November 2022

Recently the term dhimmitude is being used in some English works for analysis and interpretation of the Arabic terms dhimmah or dhimmi, the term dhimmitude thus is being associated with some subjective conditions i.e. the second class citizen and dregetory status of non-Muslim subjects under Islamic rule. The paper deals with dhimmah as a model that Islam has provided for coexistence and peaceful living with the people of other religions from the very beginning. Quran and Sunnah of the prophet Muhammad (upon him be the peace and blessings) are replete with the examples of dealing with the people of other faiths. Quran provides the basis for the theological relations, interaction and coexisting with other faiths and particularly with the people of Book i.e Jews and Christians. While the practicing model of coexistence and peaceful living in Madinah period was provided through sunnah of Prophet peace be upon himself and the Jews were accommodated as non-Muslim citizen of Islamic state. The other communities that lived within the domain of Islamic polity were also accorded the status of ahl al kitab or dhimmi or mu‘ahid prophet (upon him be the peace and blessings) set a unique pattern of granting the right of religious freedom and peaceful living within the context of an Islamic state. Thus the category of people of book was extended to the Magus of Bahrain by accepting Jizyah and granting them peace by Prophet (upon him be the peace and blessings) himself. In this way this model of coexistence was later on extended almost to all other religions by the Muslim rulers and Fuqaha as we shall see in the case of Muslim rulers of different eras. This paper aims to highlight the models adopted by the Muslim rulers for the non-Muslims living in their domain, while focusing on the fuqaha and jurist discourses on the subject. It also reflects on some recent interpretations of Islamic theory of ahl al dhimmah where the status of dhimmah is seen as a condition of deprivation. Keywords: Dhimmah, dhimmitude, social inclusion, non-Muslim, pact, aman
Impactos de uma dieta vegetariana na infância: revisão de literatura
Authors: De Oliveira Nieclyson Alexandre , Papaléo Giovanna de Amorim , Albuquerque Mariany Piedade Almeida , Lima Lucas Cordeiro , Da Silva Max William Evangelista
Published: November 2022

Introdução: O número de pessoas vegetarianas aumenta a cada ano. Uma pesquisa realizada em 2018, pelo Instituto Brasileiro de Opinião Pública (IBOPE), demonstra isso ao apresentar que 14% da população brasileira se declara vegetariana. Diante do alto índice de vegetarianos na população, é válido conceber que há pais vegetarianos que estendem essa dieta a seus filhos. Assim, é necessário indagar que efeitos esse tipo de dieta pode ter no desenvolvimento infantil. Objetivo: Analisar os impactos que uma dieta vegetariana pode ter nas crianças. Metodologia: Trata-se de uma revisão narrativa. Foi utilizada a base de dados LILACS, na qual foi realizada a busca pelas palavras-chaves: Children, Diet, Vegetarian. A busca resultou em 14 artigos, nos quais foram selecionados 5 que se relacionavam ao tema, publicados nos últimos 5 anos, gratuitos. Resultados e Discussão: A Academia Americana de Nutrição e Dietética, considera benéfica a introdução de uma dieta vegetariana na alimentação infantil, em contraponto a Academia Americana de Pediatria não recomenda esse tipo de dieta na infância. A principal preocupação é sobre possíveis deficiências nutricionais que crianças com essa dieta possam ter como, por exemplo, baixa energia, pois com a alimentação vegetariana há uma ingesta calórica mais baixa; diminuição de absorção de nutrientes, pois, normalmente, há um excesso na ingesta de fibras o que dificulta essa absorção; deficiência de cianocobalamina, vitamina B12, que pode afetar diretamente o sistema nervoso. Porém, existem recomendações para possíveis déficits que uma dieta vegetariana possa causar, esses podem ser revertidos com uma dieta balanceada e suplementação de sais e vitaminas.  Conclusão: Apesar de não haver um consenso entre as entidades especializadas, associações nutricionais de diversos países estabeleceram que uma dieta vegetariana, desde que balanceada e acompanhada por profissionais, pode proporcionar diversos benefícios à saúde e ser aplicada em qualquer idade.
Icterícia neonatal: principais etiologias
Authors: De Sousa Piter Picole Silva , Calixto Gabriela Chaves , Rosa Joana Maia de Melo
Published: November 2022

Introdução: A icterícia neonatal, achado comum nos recém-nascidos, ocorrendo em até 60% dos casos, decorrente da hiperbilirrubinemia, com níveis séricos >5mg/dL. Isso acontece em decorrência da adaptação fisiológica ao metabolismo da bilirrubina ou por processo patológico. Objetivo: Esclarecer as principais causas de icterícia neonatal. Metodologia: Revisão de literatura nas bases Scielo, PubMed e Revista Científica, utilizando-se os termos causa da icterícia neonatal. Resultados e Discussão: A hiperbilirrubinemia, embora muitas vezes benigna, se excessivamente elevada pode ocasionar kernicterus, devido a isto devem ser mantidos sobre monitorização até remissão do quadro. A hiperbilirrubinemia pode decorrer do aumento da bilirrubina indireta ou direta, sendo o esperado que ocorra declínio a níveis normais em até uma semana. A icterícia deve ser detectada visualmente por ectóscopia e a níveis sérios de bilirrubinas totais (BT) >4-8 mg/dL. Deve ser feita investigação da etiologia da hiperbilirrubinemia por exames laboratoriais quando ocorrer em RNs nas primeiras 24 horas de vida ou com valores de BT superiores a 15 mg/dL, indiferente à idade pós-natal. A icterícia neonatal pode ser em decorrência da sobrecarga de bilirrubina ao hepatócito, como ocorre por doenças de origem imune (incompatibilidade Rh, antígenos irregulares), enzimáticas (deficiência de G6PD, esferocitose, etc), decorrente de infecções, por coleções sanguíneas extravasculares, na policitemia ou em caso de circulação êntero-hepática aumentada de bilirrubina; ou pode ser em decorrência da  deficiência ou inibição da conjugação de bilirrubina, como ocorre em quadros de hipotiroidismo congênito, na síndrome da icterícia pelo leite materno ou na síndrome de Gilbert ou de Crigler Najjar tipos 1 e 2. Conclusão: A icterícia neonatal apresentasse como multifatorial e a importância de identificar a sua etiologia está em direcionar a forma adequada de tratamento visto que podem ocorrer sequelas graves pelo presente quadro que pode inicialmente ser visto como comum.
O manejo da hemorragia digestiva alta varicosa na urgência
Authors: Brondani Lara , Leite Cleber Queiroz
Published: November 2022

Introdução: A hemorragia digestiva alta (HDA) é geralmente conceituado como sangramento proximal ao ligamento de Treitz, o que leva à hematêmese, melema ou a episódios de sangramento com origem obscura. Sendo assim, os pacientes classificados como de risco muito baixo de necessidade de intervenção ou óbito, podem ser manejados ambulatorialmente. Contudo, a duração, gravidade e o volume do sangramento são particularidades essenciais a serem analisadas para fins de gerenciamento. Objetivo: Analisar o melhor manejo e a conduta em pacientes com HDA varicosa. Metodologia: Trata-se de uma revisão integrativa onde a busca ocorreu na PubMed e LILACS. Como estratégia, utilizou-se artigos completos, publicados entre 2018 a 2022, no idioma português e espanhol e os descritores “hemorragia digestiva alta varicosa”, “diagnóstico” e “tratamento”. Resultados e Discussão: Encontrou-se quinze publicações. Após a leitura dos resumos, foram selecionados cinco. A endoscopia precoce, realizada dentro de 24 horas da apresentação do episódio, é recomendada na maioria dos pacientes, pois confirma o diagnóstico e permite o tratamento endoscópico de maneira direcionada, incluindo injeção de adrenalina, termocoagulação, aplicações de bandas e clipes. Contudo, apesar do sucesso da terapia endoscópica, o ressangramento pode acontecer em torno de 10 a 20% dos pacientes. Ademais, nesses casos é recomendado realizar uma segunda tentativa de terapia endoscópica. Pode acabar sendo necessário realizar a arteriografia com embolização ou cirurgia se houver um sagramento persistente e grave. Nesse sentido, o foco principal será restabelecer o status hemodinâmico do paciente, seguido pela endoscopia precoce, como também o octreotídeo intravenoso deve ser realizado precocemente nos casos em que haja suspeita de varizes. Conclusão: Em suma, a endoscopia segue sendo o método de escolha para intervenção de sangramentos varicosos, porque resulta em morbidade reduzida e minimiza as internações hospitalares, os perigos de sangramentos recorrente e a necessidade de cirurgia nos pacientes que apresentam mais instabilidade hemodinâmica.
Abdome Agudo Obstrutivo - Diagnóstico e Alterações na Tomografia de Abdome
Authors: Da Silva Lucas Lima Verde Santos , Silva Lorena Cunha , De Lira Lucas Yuri Batista , Gama Pedro Figueiredo
Published: November 2022

Introdução: Abdome agudo obstrutivo caracteriza-se pela interrupção do trânsito intestinal, acarretando quadro clínico com dores abdominais difusas do tipo cólica ou periumbilicais, associadas a náuseas, vômitos, cessação da eliminação de flatos e fezes e distensão abdominal. O melhor exame diagnóstico de escolha é a tomografia computadorizada (TC) por ser mais fidedigna ao detectar uma causa urgente de obstrução ou fornecer informações sobre diagnósticos alternativos. Objetivo: Evidenciar a pertinência da TC para o diagnóstico do abdome agudo obstrutivo e seu manejo adequado. Metodologia: Foi realizada pesquisa bibliográfica nas principais plataformas digitais (LILACS, Scielo, Pubmed), onde foram encontrados 10 artigos, dos quais 4 foram selecionados. Resultados e Discussão: Observou-se que no abdome agudo obstrutivo as principais etiologias são a obstrução intestinal, a intumescência e o corpo estranho. Os sinais tomográficos característicos associados a estas causas são fundamentais para complementar o diagnóstico clínico. Nesse sentido, os principais achados encontrados foram a dilatação das alças intestinais, com calibre superior a 2,5cm, presença de nível hidroaéreo no seu interior e desproporção com segmento de alça distal com calibre normal, indicando o nível da obstrução. Ademais, outros achados são massa intraluminal com densidade de gordura dada pelo mesentério invaginado, massa reniforme com espessamento da parede intestinal e massa com áreas alteradas de baixa e alta atenuação dada pela confluência de tecidos moles, líquido e gás. Por fim, observou-se área fusiforme ou ovoide e alterações inflamatórias, com o cólon subjacente podendo apresentar sinais de compressão extrínseca ou mostrar aspecto normal na TC. Conclusão: O abdome agudo obstrutivo deve ser investigado por uma equipe multidisciplinar visando a melhor alternativa para pacientes. Portanto, faz-se necessário que medidas efetivas sejam tomadas a respeito do tipo de exame a ser solicitado, fazendo uso da TC para obter informações mais precisas sobre a origem da patologia e melhor direcionamento do diagnóstico.
Structure Prediction and In-silico Designing of Drugs against Plant Homeodomain Finger Protein 14 for Suppression of Malignant Transformation and Tumorigenicity of Non Small Cell Lung Cancer
Authors: Devgun Manish , Nandini Nandini , Singh Lalit , Sharma Saurabh
Published: November 2022

PHF14 (PHD finger protein 14) is associated with Plant Homeodomain (PHD) Finger Protein family. This chromatin-binding protein interacts with histones. PHF14 overexpression has gained attention due to compelling evidence of its involvement in cell proliferation of various cell lines. PHF14 plays a critical function in the induction of pulmonary fibrosis, and actively participate in cell mitosis which makes it a probable target in the treatment of lung fibrosis and can also be utilized as a biomarker in evaluation and management of non small cell lung cancer. A model of PHF14 protein was prepared by homology modelling and was verified by Ramachandran plot. This model of PHF14 protein was acknowledged by Protein Model Data Base (PMDB) and has been assigned PMDB ID: PM0084114. The DrugBank database was used to obtain ligands, to dock against PHF14 by applying PatchDock technique. The structure of the selected ligand (DB08438) was then modified by means of ACD/ChemSketch 8.0 to secure 22 new in silico ligands, which were subjected to the docking procedure. The docking results identify ligand 31 to possess a high binding affinity with the target protein. The in silico docking results suggests that ligands 31, 12, 13, 14, 15, 16, 18, 19, 20, 21, 22, 23, 26, 29, 30, 31, 32, and 33 have a high preference for binding with PHF14 and these compounds should be thoroughly probed so as to develop potential chemical entities for the suppression of malignant transformation and tumorigenicity of non small cell lung cancer.
Antibacterial activity of Tilapia Fish Scales derived Chitosan; Future towards Biomedicines
Authors: Chaudhry Gul-e-Saba , C S Thirukanthan , Mohamed Zin Nor Atikah , Yik Sung Yeong , Tengku Muhammad Tengku Sifzizul , AWM Effendy
Published: November 2022

The research effort aimed to evaluate the antimicrobial activity of Chitosan derived from Tilapia fish scales. The production of Chitosan achieved by chemical hydrolysis involving demineralization, deproteinization and deacetylation. The antibacterial activities performed against Staphylococcus aureus, Bacillus cereus, Streptococcus agalactiea, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi. The bacteriostatic and bactericidal effect is measured via Minimum Inhibitory Concentrations (MIC) and the Minimum Bactericidal Concentrations (MBC). Chitin yielded 32.74% from 100 grams of dried fish scales in this study, whereas Chitosan yielded 62.13%. Also, the ratio of MBC/MIC determination reveals the bacteriostatic effect of a Chitosan at given concentrations. Therefore, the antibacterial cationic polymer isolated from Tilapia fish scales utilized in various industrial field. The use of derivatization shows a positive role in control drug release systems.
Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Volatile components from Coral “BETADINE” (Jatropha multifida Linn) Leaves
Authors: Hanafi Hanafi , Rochaeny Henny , Melati Sirait Septilina , Rahmatia Lintannisa , Setyawati Sri Redjeki
Published: November 2022

Betadine Plants leaves were extracted with methanol and carried out by maceration then evaporated with a rotary evaporator. The purpose of this experiment was to determine the composition of chemical compounds contained in the methanol extract of betadine (Jatropha muitifida Linn) leaves by GC-MS. The results of this analysis can be used as a reference in determining the antimicrobial activity of betadine leaves. The results of GC-MS on betadine leaf extract samples detected 27 peaks of compounds, the 3 most dominant compounds were at retention times of 18,072, 19,950 and 20,058, namely 9-Hexadecenoic acid, methyl ester, (Z)-; 7-Hexadecenoic acid, methyl ester, (Z)-; Methyl hexadec-9-enoate; 9,12,15-Octadecatrienoic acid, methyl ester, (Z,Z,Z)-; and Phytol.
Comparison of Complete Blood Count Parameters using EDTA, Sodium Citrate, and Heparin Anticoagulants
Authors: Made Sedana Putra Anak Agung , Hernaningsih Yetti
Published: November 2022

A complete blood count is a routine blood examination performed in laboratories. EDTA is the standard anticoagulant used in complete blood count examination. The use of ethylenamineintetraacetic acid (EDTA) may cause pseudo thrombocytopenia. The alternative to EDTA is sodium citrate and heparin anticoagulants. This study aimed to compare the results of complete blood count parameters using EDTA, sodium citrate, and heparin anticoagulants for the necessity of health service in the laboratory. The design of this study was a cross-sectional observational analytic done from October 2020 until November 2020. The participants of this study came from 62 adults who look healthy recruited in Medical Check-up Department. The sample was collected using K2- EDTA, 3.2% sodium citrate, and heparin tubes with volumes of 3ml, 3ml, and 4ml respectively. The sample was then examined using Sysmex XN 1000 hematology analyzer. There were no significant differences between the result of hemoglobin (HBG), red blood cells (RBC), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red cells distribution width (RDW), and white blood cells (WBC) parameters. The result of platetelet (PLT) was significantly different between the three tubes. The results of platelet examination with sodium citrate and heparin tubes were lower than those obtained with the EDTA tube. EDTA is still the best choice for a complete blood count, but sodium citrate and heparin anticoagulants can be used as alternatives for testing.
Isolation of Isoflavones from Iraqi Trifolium pretense
Authors: Mohsen Naseer Noor , Aburjai Talal A. , Al-Jubori Ibrahim S.
Published: November 2022

Objective: Trifolium pretense considered one of the most important medicinal plant which belongs to Fabaceae family, this plant commonly known as Red clover, its native region is Europe, Western Asia, and northwest Africa, but planted and naturalised in many other regions. The main compoundes found in Trifolium pretense are isoflavones which is determinrd by genistein, daidzein, biochanin A and formononetin. These compounds structurally related to estradiol-17 beta. Mangement of cancer is the main medicinal uses of Trifolium pretense in addition to decrease cholesterol and LDL and had anti- inflammatory activity, antioxidant and its effect on the Skin, Appendages, and Mucosal Status in Postmenopausal Women. This study was designed to isolate the main isoflavones from Trifolium pretense. Methods: The plant was collecting and washed by tap water to remove dirt and dust and rinsed with distilled water then dried at room temperature. Then, the plant was extracted by ethanol in a soxhlet apparatus and the extract partitioned with ethyl acetate by separatory funnel. The ethyl acetate layer was subjected to standard methods for active constituents identification, and purified by column chromatography. The collected fractions were analysed by TLC comparing with standard isoflavones (genistein, daidzein, biochanin A and formononetin). Preparative TLC was performed using 0.5 mm thickness of silica gel; the isolated bands were conducted with AR grade acetone. Iisolated isoflavones were characterized by 1H and 13-CNMR. Results: Isolated isoflavones (genistein, daidzein, biochanin A and formononetin) were identified by melting points which were identical with to that which were reported in the literature. Moreover, the ¹H-NMR and 13C-NMR analysis were used to identify the target compounds in CDCl3 solvent, and the values of chemical shifts have been discussed according to the literature of analogous compounds.
Identification of active compound and Antibacterial activity against gram-positive and gram-negative bacteria of Chromolaena odorata leaf extract
Authors: Zainab Zainab , Nurlailah Nurlailah , Ikhwan Rizki Muhammad
Published: November 2022

Antibacterial from natural ingredients, such as medical plants can be used as an alternative medicine. The aims of this study were to identify active compounds and antibacterial activity from the leaf extract of Chromolaena odorata, especially to against gram-positive bacteria and gram-negative bacteria. The methods of this study were making simplicia powder, extracting the leaves using ethanol, phytochemical screening using the tube method with specific reagents. Fractionated with chloroform and ethyl acetate and analyzed by Gas Chromatography–Mass Spectrometry (GC-MS) to identify the active compounds. Antibacterial activity used diffusion method. We also determined the minimum inhibitory concentration (MIC) and minimum kill concentration (MKC). The results of the chloroform fraction showed 14-Methyl-Pentadecanoic Acid; 9-Octadecanoad; 2(2-(2, 5-Ditiacyclopentyl)-N-Propyl-3 Isopropanol; Bis (dichloromethyl)-ether. The results on the ethyl acetate fraction were 4-oxopentanoid acid or Levulinic acid; 4, 4- dieutero-hepten-1-ol; 1, 2, 2-trichloro-1, 1-difluoromethane; and 1-ethyl-2-methyl-3-oxoheksanoic acid. In addition, inhibition zone leaf extract 10% w/v against S. epidermidis 18.44 mm; S. mutans 19.32 mm; S. aureus 19.50 mm; P. aeruginosa 12.70 mm; E. coli 0.00 mm; and S. thypi 0.00 mm. MIC of S.aureus, S.mutans, S.epidermidis, and P.aeruginosa were 6250 ppm, 6250 ppm, 1562.5 ppm, and 9375 ppm, respectively. MKC of S.aureus, S.mutans, S.epidermidis, and P.aeruginosa were 6250 ppm, 6250 ppm, 1562.5 ppm, and 12500 ppm, respectively. The conclusions of this study were the leaf extract of Chromolaena odorata contained terpenoid, phenolic and flavonoid. Antibacterial activity of this extract showed strong activity on S. aureus, S. mutans, S. epidermidis, and P. aeruginosa bacteria.
A Review of Dental Caries Classification Systems
Authors: M Shruthi. , Srinivasan Daya , Eagappan Senthil , Louis Joe , Natarajan Divya , Meena Saraswathy
Published: November 2022

Dental caries is a preventable, infectious disease that forms a significant portion of daily dental practice. Caries occurs due to an imbalance in demineralization and remineralization process resulting in mineral loss over a period of time. Detecting and recording carious lesions is an essential component of the dental hygiene process. Dental caries present with a wide range of clinical features affecting all age groups and all surfaces of teeth. The first attempt in classifying dental caries was by G.V Black. With the advancements in preventive strategies, various classification systems have been proposed to classify dental caries by limiting the cavity size and retaining a maximum natural tooth structure. All classification systems must be simple, reliable, comprehensive, and validated. It is important to classify to aid communication, outcome, diagnosis, and treatment plan. The purpose of this article is aimed to overview the classifications of dental caries with their respective strengths and demerits.
Pre-sentence reports for Aboriginal and Torres Strait Islander people: an analysis of language and sentiment
Authors: Coulter Darcy , Forkan Abdur
Published: November 2022

Pre-sentence reports (PSRs) provide information to courts on an individual’s background, circumstances, risks, needs and plans. Research has found that PSRs focus heavily on risk of recidivism, while identification of prosocial cultural and community factors is limited. This study sought to describe the language and sentiment in these reports. We studied PSRs written for Aboriginal and/or Torres Strait Islander people sentenced by the mainstream County Court of Victoria and the Koori Court Division of the County Court of Victoria. Findings indicate that risk-related words are more prevalent than words associated with strengths and culture in PSRs submitted to both courts. While the frequency of positive and negative sentiment was low in PSRs for both courts, those for the Koori Court were more positive in sentiment.
THE DEVELOPMENT OF THE CONTROL UNIT OF A LABORATORY STAND FOR SIMULATION THE THERMAL MODS OF RADIO-ELECTRONIC DEVICES
Authors: KAPACH T. , KHAMICHONAK M. , MALADZECHKINA T.
Published: November 2022

The control unit included in the laboratory stand for modeling thermal modes of radio-electronic means is presented. The main functions performed by the control unit of the laboratory stand are given, the features of its design are described. The rationale for choosing the Arduino IDE software environment for software development is given. A selection of libraries used to organize the interaction between the Arduino board and the components

of the stand was carried out. The software for the control unit of the laboratory stand has been developed and reviewed in detail.