bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative analysis of the criteria for conducting clinical trials
of medicines in Russian Federation, the United States of America
and the European Union
Authors: Lebedeva Diana A.
Published: March 2023

Introduction. As a part of the admissions to the market for medicines, there are requirements and restrictions that apply to the application of the “risk-based approach”. Requirements differ by subject, object of the tstudy, individual characteristics. The author carried out a comparative legal analysis of the requirements and criteria established by the legislation of the Russian Federation, USA, and EU.
The purpose of the study is to identify criteria, limitations in the process of conducting clinical trials of medicines involving humans.
Material and methods. The author studied the Russian legislation in the field of restrictions on clinical trials of preparations and analyzed the relevant experience of the USA and EU. Methods of structural analysis, logical generalizations, classifications, comparative legal method were used.
Results. The Russian regulation of drug trials provides for a fairly wide and complete list of restrictions and requirements that contribute to the implementation of a risk-based approach. At the same time, EU and USA legislation is more focused on protecting the rights of participants under study, Russian standards must be supplemented in terms of work with minors during clinical trials. The Russian legal model of clinical trials may develop in the area of ​​liberalizing restrictions and establishing more detailed the procedure for participation in the clinical trials of certain categories of persons.
Limitations. This article is compiled on the basis of 67 sources available to the author (student libraries, Russian databases of articles and journals). The study is limited to a sample of 27 sources, of which 10 are normative acts on the topic of work.
Conclusion. The article develops criteria for comparing the limitations of clinical trials of medicines in the Russian Federation, USA and EU, and suggests recommendations for improving the Russian regulatory model. A transparent range of requirements for conducting clinical trials ensures the safety for the population, including certain categories of people. Russian regulation should be improved in terms of ensuring the protection of the rights of the maximum number of participants, depending on national priorities, taking into account the best foreign practices.
Pengaruh Standar Akuntansi Pemerintahan dan Sistem Pengendalian Internal Terhadap Good Governance di Dinas Ketahanan Pangan dan Pertanian Kabupaten Kuningan
Authors: Yulientinah Dewi Selviani , Sya’bani Suci Nur Afipah
Published: March 2023

Dinas Ketahanan Pangan dan Pertanian merupakan salah satu lembaga yang memiliki peran penting dan akses yang besar terhadap keberhasilan pembangunan pertanian. Penelitian ini bertujuan untuk mengetahui pengaruh standar akuntansi pemerintahan terhadap good governance di Dinas Ketahanan Pangan dan Pertanian Kabupaten Kuningan, pengaruh sistem pengendalian internal terhadap good governance di Dinas Ketahanan Pangan dan Pertanian Kabupaten Kuningan, serta pengaruh standar akuntansi pemerintahan dan sistem pengendalian internal terhadap good governance di Dinas Ketahanan Pangan dan Pertanian Kabupaten Kuningan. Penelitian ini menggunakan metode kuantitatif dan teknik pengumpulan data yaitu kuisioner yang disebar kepada responden dalam penelitian. Populasi dan sampel dalam penelitian ini yaitu pekerja Dinas Ketahanan Pangan dan Pertanian Kabupaten Kuningan. Teknik analisis data yang digunakan yaitu : uji validitas, uji reliabilitas, uji normalitas, analisis korelasi spearman rank, analisis regresi berganda, koefisien determinas, uji t dan uji f dengan menggunakan bantuan program komputer SPSS. Berdasarkan hasil uji t, pengujian hipotesis standar akuntansi pemerintahan terhadap good governance diperoleh t hitung > t tabel atau 5,112 > 1,98827 yang artinya terdapat pengaruh yang signifikan antara variabel bebas dan variabel terikat. Sedangkan pengujian sistem pengendalian internal terhadap good governance diperoleh t hitung > t tabel atau 4,501 > 1,98827 yang artinya terdapat pengaruh yang signifikan antara variabel bebas dan variabel terikat. Berdasarkan hasil uji f f hitung > f tabel atau 80,625 > 3,10 yang berarti terdapat pengaruh signifikan secara simultan dalam pengujian standar akuntansi pemerintahan dan sistem pengendalian internal terhadap good governance.
Hindi Kesimhanesi Atıksuyunda Fotokatalitik Arıtma ve Taguchi Metodu ile Optimizasyon
Authors: DOĞDU OKÇU Gamze , ŞEN Nazmiye Ebru
Published: March 2023

Heterojen fotokataliz, kimyasal oksijen ihtiyacı (KOİ), azot ve fosfor gibi yüksek seviyede organik kirleticiler içeren kanatlı endüstrisinden ham hindi kesimhanesi atık sularının arıtımında umut verici yeşil bir teknoloji olup arıtım potansiyeli şimdiye kadar yeterince incelenmemiştir. Bu çalışmada, hindi kesimhanesi atık suyunun fotokatalitik bozunması, Taguchi yöntemine dayalı bir yanıt yüzeyi metodolojisi (RSM) uygulanarak incelenmiştir. Bu amaçla, kritik çalışma parametreleri; fotokatalizör konsantrasyonu (0,5-3 g/L, A), pH (2-10, B), hidrojen peroksit (H2O2) konsantrasyonu (0-20 mmol/L, C), lamba türü (UVA, UVC, D) ve katalizör tipi (TiO2, ZnO, E) optimize edilmiştir. Bu deneysel faktörler karışık seviyelerde (43 22) ele alınmış ve L16 testleri uygulanarak çalışma parametreleri optimize edilmiştir. ANOVA sonuçlarına göre katalizör ve H2O2 konsantrasyonu ile pH parametreleri atık sudan KOİ gideriminde en önemli etkiye sahiptir. Optimum koşullar şu şekilde elde edilmiştir: başlangıç katalizör dozu 0,5 g/L (Seviye 1), pH 2 (Seviye 1), H2O2 konsantrasyonu 10 mmol/L (Seviye 3), lamba tipi UVA (Seviye 1) ve katalizör tipi ZnO (Seviye 2). Bu şartlar altında deneysel ve tahmini KOİ giderim verimleri sırasıyla %62 ve %63 olarak elde edilmiştir. Ayrıca yapılan çalışmada, işletme maliyetini oluşturan en önemli faktör elektrik enerjisi tüketimi olurken kimyasal ve elektrik enerjisi maliyeti optimum koşullar altında 1,315 TL ve 32,325 TL olarak elde edilmiştir.
Impact of Climate Change on Intermodal Transportation
Authors: David Merly
Published: March 2023

Purpose: The purpose of the study is to examine the impacts of climate change on intermodal transport.

Methodology: This study adopted a desktop methodology. This study used secondary data from which include review of existing literature from already published studies and reports that was easily accessed through online journals and libraries.

Findings: The impact of climate change on intermodal transport is associated with heavy rains, carbon dioxide emissions and greenhouse gases. The study also found that climate change has made the transport sector to develop strategies to mitigate the effect of climate change.

Unique Contribution to Theory, Practice and Policy: The study used the agro-economic models and ricardian model for climate change assessment. The study recommended that additional maintenance and rehabilitation costs may be required to compensate for additional distresses related to climate change. Therefore there is need for heavy investment of emergency funds for repair and maintenance of the way, this includes ports and seas.
Temperature Change in the Contiguous 48 States Between 1901 and 2020
Authors: Cappelletti Lucas W. , Lash Benjamin L. , Levine Noah E. , Sommers Paul Martin
Published: March 2023

Climate change has become a global emergency.  Many people have studied the rise in temperatures over the last few decades.  But few have studied how monthly average temperatures at the state level in the United States have changed for more than a century.

The authors divide the 120-year period January 1901 to December 2020 into two 60-year periods and then compare the monthly average temperature in each period for each of the 48 contiguous U.S. states.  When these data are divided into seasons, the largest changes are observed for winter (December, January, ad February) and summer (June, July, and August) months, especially among states that have coastal access to the Pacific Ocean or the Atlantic Ocean in the northeast. 

Apart from presenting a series of two-sample t-tests for each of the 48 states for all seasons combined and one for each of the four seasons, the authors also present color-coded maps summarizing the statistical results for the winter and summer seasons.  The maps use the p-value of each two-sample t-test to show which states in each season between the two 60-year periods are getting cooler (green, light blue, dark blue) and which states are getting warmer (yellow, orange, red).
Corrections Officer Turnover at Marquette Branch Prison During the COVID-19 Pandemic
Authors: Bonesteel Amanda
Published: March 2023

During the course of the COVID-19 pandemic, many businesses and organizations saw significant turnover rates, and in the field of corrections, the situation was no different. This case study will review and interpret the work environment factors that led to the resignation of corrections officers at the Marquette Branch Prison between April 1, 2020, and April 1, 2022, as there was a significant increase in resignations as well as violent assaults on employees during this time. The objective of this study is to explore the perspectives and experiences of resigned corrections officers to identify the reasoning behind their resignations and to suggest possible strategies to reduce turnover rates, improve employee working conditions, and improve the well- being of corrections officers at Marquette Branch Prison. This project is significant because it gives corrections officers who left their jobs a chance to talk about their experience, identify factors that lead to poor working conditions and decreased employee well-being, and it allows for suggestions of ways to improve work environment conditions, job satisfaction, and employee wellness. There are few similar studies available, and this will be the first research that looks at turnover at a specific prison facility during the COVID-19 pandemic. Marquette Branch Prison is a large employer in its community, and understanding the effect that its work environment has on employees—who are community members—and their families is essential.
Evaluating the effects of implementing a hospital-acquired pressure injury risk assessment hand-off tool
Authors: Baldwin Stena , Junious DeMonica
Published: March 2023

More than 2.5 million patients suffer from pressure ulcer injuries each year, estimating that 60,000 die from complications (Joint Commission Center for Transforming Healthcare, 2021). Hospital acquired pressure injuries (HAPI) present as skin and muscle damage, slowed healing, and increased pain and infections that result from delayed wound care and treatments to fragile areas. Reports from Rondinelli et al. (2018) showed that implementing a HAPI risk assessment hand-off tool worked to reduce such events.

In 2021, a coastal community hospital located in Southeast Texas recorded 5% HAPI events, which resulted in the creation of a student developed HAPI risk assessment hand-off tool. The aim of this quality improvement (QI) project was to decrease HAPI events in the Cardiothoracic IMU to 0% by February 2022. Kurt Lewin's Change Theory was used to guide project interventions.

After receiving project approval, four changes were implemented. A unit champion, responsible for monitoring the accuracy of Braden Score documentation was designated. Nurses implemented interaction-based patient repositioning every 2 hours and participated in monthly HAPI prevention and education meetings. Lastly, nurses completed the hand-off tool to verify staff compliance. Chart audits and a student developed questionnaire was used to determine the usefulness of the HAPI risk assessment hand-off tool. After one month of chart audits, and use of the hand off tool, the HAPI occurrence rate decreased to 3%. This project concluded that the student developed HAPI risk assessment hand-off tool had no significant effect on the reduction of HAPI occurrences within the cardiothoracic IMU.
The Construction of Women in US History Textbooks
Authors: Jabjiniak Kylie , McCabe Anne
Published: March 2023

Due the influence of historical perceptions on contemporary world views and the capacity of language to reflect values and ideas, the critical examination of how history is framed and taught is a necessary academic endeavor. The study of textbooks is particularly crucial because of their authoritative nature and fundamental impact on education. Through a systemic functional linguistic analysis of selected texts from an introductory, college-level US history textbook, this paper examines the construction of women in educational historical narratives. Three selections focused on women were selected from textbook chapters, each representing a different century since the founding of the United States, and each selection was analyzed using the theme/rheme construct. The results underscore the ongoing limitations to the portrayal of women’s roles and agency in history textbooks as well as concerns of reinforced patriarchal constructions of power and women’s societal place that are reflected at the level of linguistic choices in textbook-writing.
THE LIFE IN JAIL: LIVED EXPERIENCES OF PERSONS DEPRIVED OF LIBERTY
Authors: Gales Eliel Jim P. , Omega Gun Real L. , Cano Jenny C. , Tiu Carlito M. , Apatan Ansel C. , Tindugan Arbie E. , Garcia Ronnel Ian M. , Chua Liza L.
Published: March 2023

This study investigated the lived experiences among Persons Deprived of Liberty (PDL) using phenomenological approach of qualitative research. Five PDL from Surigao City, Philippines were chosen as informants of the study based from the years of imprisonment. The data were gathered through in-depth interviews focusing on the informants’ personal experiences inside and outside the jail. Based on the analysis of data, 23 concepts were formulated from significant meaning units, and the concepts were categorized into five propositions. From these categories, 4 themes emerged: Connections, Self-reflection, Difficulties and Challenges, and Adapting for survival. The findings of this study provide an important foundation from which to increase public awareness and to understand the experiences among PDL who went through change but faced difficulties and challenges inside and outside the jail. It involved the negative and positive experiences; negative because they experienced longing for their family, loneliness, and hardships especially as they encounter discrimination by the people outside, and positive because they experienced change inside the jail and learned from their mistakes in the past. Such a phenomenon at some point leads ex-convicts to self-reflect and change their lives into good examples. These experiences of PDL may influence and inspire the youth to avoid any crimes and help them realize that life inside the prison is not easy as they think. From these experiences, people can have an understanding and be aware of what would life be like inside the jail and may develop a more productive consciousness of one’s life.
De eeuw van de grote reparaties
Authors: Van Tussenbroek Gabri
Published: March 2023

Dit artikel gaat in op een aantal zeer ingrijpende reparaties van Amsterdamse gebouwen in de zeventiende en achttiende eeuw. Het gaat daarbij om twee soorten reparaties: herstel van fundamenten en reparatie van steun- en kapconstructies. Problemen met fundamenten konden worden veroorzaakt door een fluctuerende grondwaterstand, een te hoog gelegd fundament of ondeugdelijkheden in de constructie, al dan niet in combinatie met onregelmatigheden in de natuurlijke drassige ondergrond. Behalve huizen, waarvan de fundamenten al veel eerder werden verstevigd, kwamen vanaf de vroege zeventiende eeuw reparaties van torens voor. Daarbij werd doorgaans een extra fundering geslagen waaraan de bestaande structuur werd verankerd. Bekende voorbeelden zijn de Stadhuistoren, de Montelbaanstoren en de toren van de Oude Kerk.

Reparatie van steun- en kapconstructies had vaak een andere reden: achterstallig onderhoud, te zware of onjuiste belasting, bouwfouten en krachtenwerking van buitenaf, zoals wind of andere krachten. De reparatie van de kap van de Burgerzaal in 1700 werd uitgevoerd vanwege een ondeugdelijke constructie en inwatering. Een voorbeeld van krachten van buitenaf vormt de ook in Amsterdam gevoelde aardbeving van Lissabon van 1 november 1755 en twee latere bevingen, in december van dat jaar en op 18 februari 1756. Deze aardschokken waren vermoedelijk de aanleiding dat het stadsbestuur kort hierna bouwvallige huizen in de stad liet slopen, en ook om de Montelbaanstoren en de Oosterkerk ingrijpend te herstellen.

De in dit artikel gepresenteerde voorbeelden laten zien dat er soms uiterst kostbare herstellingen moesten worden uitgevoerd om het voortbestaan van een gebouw te garanderen. Hiermee wordt tevens duidelijk dat dit soort herstel weliswaar kan worden ingegeven door een incident zoals een aardbeving, maar dat herstel een fenomeen is dat onlosmakelijk is verbonden met de lange levenscyclus van gebouwen
Brown over Rietveld
Authors: Hoekstra Rixt
Published: March 2023

In the post-war historiography of Dutch modern architecture, the monograph of Gerrit Rietveld written by the American architectural historian Theodore Morey Brown (1958) played a pioneering role. The Work of G. Rietveld, Architect was the first monograph of a by then already internationally renowned Dutch architect and since it was written in English it was also the only source of detailed information about Rietveld for an international readership. Brown was the first art historian in the Netherlands to write a dissertation on a living architect; as such, his book signalled the start of modern architectural history as practised by art historians. Yet despite the fact that it is almost impossible to overstate the significance of Brown’s study, the book remains until this day a curiosity. Why was the first scholarly work on Rietveld written by an American scholar and published in the English language? Who was Theodore Morey Brown and how did he end up at a Dutch university in the 1950s? This article examines the history of Brown’s book: its genesis from a research initiative by post-war Dutch professors of art history to the contents of the final book. It also discusses the international historiographical debate in which Brown participated. Brown’s book heralded a new era in the relationship between the art historian and the architect, one that was connected with the challenge to write contemporary history from an ideologically engaged attitude. As an ‘operative history’ Brown’s book was distinguished by its collaborative nature. While it was a book about a single architect written by a single historian, in the background there was a ‘team Rietveld’ consisting of, among others, the historian Pieter Singelenberg and the designer Truus Schröder-Schräder, who were vital to its creation. Only with the help of these people could the work of Rietveld be made accessible to a foreign scholar who, upon arrival in the Netherlands, did not speak the Dutch language. This article argues that Brown’s book was important not only for the historiography on Rietveld. The book also had an institutional significance as it ushered in the study of modern architectural history by art historians in the Netherlands.
Tanken in de stad
Authors: Vanhaute Thomas
Published: March 2023

De wereldwijde automobielindustrie bevindt zich de laatste jaren in de grootste omwenteling sinds haar ontstaan, nu zo’n honderd jaar geleden. De nog lopende omschakeling van aandrijving door fossiele brandstoffen naar een elektrische krachtbron luidt het einde van een tijdperk in. Deze revolutie is een goede aanleiding om terug te kijken op honderd jaar rijden op benzine– en de bijbehorende service-architectuur. In dit kader geeft Thomas Vanhaute een representatief overzicht van de ontwikkeling van straatpomp naar selfservice station in Antwerpen en de directe omgeving in de periode 1945 tot en met 1975. Het is een beknopte weergave van een architectuurhistorisch onderzoek op basis van meer dan 200 bouwaanvragen en milieuvergunningen uit het Stadsarchief van Antwerpen waarin een aantal parameters van naderbij bekeken en geanalyseerd werden. Hierdoor was het mogelijk om ontwikkelingslijnen van de naoorlogse service- en benzinestations bloot te leggen en vervolgens te duiden in het licht van de socio-economische en stedenbouwkundige situatie en transformaties in en rond de stad. Door het historisch onderzoek te koppelen aan actueel in situ-onderzoek, konden bovendien de nog bestaande restanten van deze structuur opgespoord en voor herwaardering en bescherming aangemerkt worden.
Over de bouwkunst
Authors: De Raedt Nele
Published: March 2023

Bespreking van een boek van Leon Battista AlbertiVertaling Gerard Bartelink, nawoord Koen Ottenheym
Apologetics: Learning from C. S. Lewis
Authors:   Oxford University, McGrath Alister E.
Published: March 2023

This article introduces the world-famous Oxford academic and author C.S. Lewis as a Christian apologist. Aiming at clarity and conviction, Lewis produced a series of works aimed at communicating the reasonableness of Christianity to his own generation. Lewis’s intelligent and persuasive approach to Christianity is grounded in his core belief that Christianity makes sense of life. It commends itself by its reasonableness. For Lewis, Christianity offers a ‘big picture’ which weaves together the strands of experience and observation into a compelling pattern. Thus, apologetics is not simply about trying to persuade people that Christianity is right; it is about showing that it is relevant and existentially meaningful, able to engage life’s deepest questions and give rich and satisfying answers.
A Study on Global Funding Liquidity and Business Cycle in South Korea
Authors:   The K Association of Education Research, Chung Ji-Yeong
Published: March 2023

This study investigates the significance of the U.S. funding liquidity measure, TED spread, obtained by subtracting 3-month T-bill rate from 3-month Libor, in explaining the business cycle of South Korea and takes a look at recent changes pertaining to the transition to SOFR(Secured Overnignt Financing Rate) from Libor. This study contributes to the existing literature by empirically demonstrating the statistical significance of the global funding liquidity on the business cycle of South Korea, thereby enhancing the understanding of the business cycle in South Korea, and by examining SOFR which is gaining increasing attention. In applying the probit estimation model, a binary dependent variable is generated based on the business cycle stages and descriptive variables are constructed using term spread, short rate, and funding liquidity measures. The estimation results show that TED spread is significant in explaining the business cycle of South Korea, while the domestic funding liquidity measure proves to be insignificant, and considering U.S. term spread and TED spread along with domestic variables remarkably enhances the explanatory power. Under the circumstance that TED spread is no longer available due to the transition to SOFR, it is necessary to reassess the measurement of funding liquidity, considering recent studies which demonstrate that SOFR is less informative than Libor concerning credit and liquidity risks. Especially in case of the term SOFR, which covers vulnerabilities of overnignt rate and promotes practical use of the new benchmark rate, further research is required to figure out its informational contents on the funding conditions.
교육감과 관련한 일본의 지방교육자치제도에 대한 연구
Authors:   The K Association of Education Research, Park Jong-Ryeol , Noe Sang- Ouk
Published: March 2023

The purpose of this study is to identify the problems with the education autonomy system and conflicts of the Japan, which is implementing the local education autonomy system to find a way to resolve conflicts and disputes that occur between the Minister of Education and the educational superintendent., and to suggest reasonable improvements. In Japan, as in Korea, there are conflicts and disputes between the central government and local governments. However, what is different from us is that the autonomy of local governments has been strengthened following the decentralization reform promoted by Japan in the 1990s. The Local Autonomy Act restricts the central government's involvement with local governments, and requires its intervention to meet the specified requirements and to follow due process, detailed in the relevant laws. In other words, the case of Japan, where there is a legal regulation making the central government not restricting or interfering autonomy of local governments, suggests that more detailed regulations are required within the scope that the government’s involvement and intervention doesn’t undermine the autonomy of local governments to us, where the requirements and process of the central governments’ intervention in local governments are simplified. In Korea, similar to the National and Local Dispute Resolution Committee in Japan, an administrative consultation and mediation committee exists under Article 168, but it is ineffective because there are insufficient regulations on the authority of the committee and the effect of the decision of the committee on the central and local governments. It is necessary to prepare a new type of dispute mediation body and related regulations that can minimize the loss that may occur in case of a dispute or conflict through comparative review of dispute mediation bodies in Korea and Japan.
The Effects of Maker Education on Prospective Early Childhood Teacher’s STEAM Literacy Indexes and Empathic Ability
Authors:   The K Association of Education Research, Lee sun-young
Published: March 2023

This study was conducted to find out the effect of maker education applied in children's literature classes on the cultivation of convergence talents and empathic ability of prospective early childhood teachers. To this end, maker education was applied to a total of 23 freshmen students taking early childhood education and children's literature classes at a College in Korea, and its impact was verified through pared t-tests on convergence talent cultivation and empathic ability. First, the study showed that maker education for pre-child teachers had a positive effect on fostering convergence talent. All four areas of convergence, creativity, consideration, and communication showed statistically significant results. Second, maker education for pre-childhood teachers was found to have a positive effect on empathy. Among the two areas of cognitive empathic ability and affective empathies, cognitive empathy showed statistically significant results, but affective empathy did not. Through this study, it was confirmed that maker education has an important educational value to promote convergent knowledge necessary for the future society, and implications were drawn that it is a meaningful educational method for teachers who educate future generation.
Development of Lesson plans for Infant Development Subjects Applying the Havruta Teaching Method
Authors:   The K Association of Education Research, Choi Deahun
Published: March 2023

The purpose of this study is to reconstruct the subject to which the Havruta teaching method is applied based on the ‘2020 Standard Curriculum Outline’ for the ‘Infant Development’ subject, which is one of the essential subjects of the childcare teacher training process, and to develop lesson plans. According to the purpose of the study, related preceding studies and the outline of the standard curriculum for the 2020 childcare teacher training course were reviewed, and the final lesson plans were finalized through two expert interviews (focus group interviews). Based on the research results, the conclusions for each research question are presented as follows. First, the process of reconstructing infant development subjects to which the Havruta teaching method was applied was carried out in four stages, including analysis of relevant literature and previous research and preparation of drafts, interviews with primary experts, revision and supplementation of lesson plans for each class, and interviews with secondary experts. The final class plans were composed. Second, the teaching plan of the infant development subject to which the Havruta teaching method was applied reflected the purpose and goal derived from the two interviews with the experts participating in the research, teaching and learning and evaluation, and considerations and other opinions when applying, and included the following contents. Classes for each class are organized for the purpose of enhancing learning opportunities through self-directed learning on theories, concepts, and research methods and cultivating a positive attitude toward learning through interaction with partners. evaluation method was applied. In addition, for each class, activities were guided through the provided activity sheets, and pre-activity and interaction using SNS were actively encouraged to expand the time and space of classes.
In Vitro Propagation and Histochemical Analysis of Launaea sarmentosa (Willd.) Kuntze
Authors: Meksuwan Yurachat , Sutthinon Pornsawan
Published: March 2023

Launaea sarmentosa (Willd.) Kuntze., an edible perennial herb, is critically considered an endangered species due to its habitat destruction. In vitro L. sarmentosa propagation was therefore conducted to preserve this plant. Two types of explants including leaf and stolon were applied to induce the multiple shoots by culturing on Murashige and Skoog (MS) medium supplemented with BA (0, 1, and 2 mg/L) and 2,4-D (0, 1, 2, and 4 mg/L). The optimal shoot induction medium for both explants was MS medium containing 2 mg/l BA (presented 100 % shoot induction). Roots were induced by various types and concentrations of auxins [1-naphthalene acetic acid (NAA), indole-3-acetic acid (IAA), and indole-3-butyric acid (IBA)]. The highest percentage of rooting (70.00 ± 11.05 %) was obtained from stolon-derived shoots on MS medium supplemented with 0.1 mg/l IAA. One-hundred percent survivability was presented after transforming plantlets into a mixture of soil, sand, and peat moss (1:1:1). Starch, protein, and lipid were accumulated in leaves detected by histochemical technique. The obtained information will be a useful tool for mass propagation of L. sarmentosa and to obtain basic knowledge for plant accumulating substances.
HIGHLIGHTS

This paper highlights 2 types of sarmentosa explant including leaves and stolons have great potential to produce multiple shoots after inoculation in MS medium adding BA. All regenerated plants get success for acclimatization and transplantation to the greenhouse. In vitro plantlets of L. sarmentosa leaves accumulated fat, protein and carbohydrate which might be related with precursor of medicinal properties

GRAPHICAL ABSTRACT
Pumpkin Rind and Seeds Extracts Inhibit α - Glucosidase and Nitric Oxide Production and Promote Chlorella ellipsoidea Growth in Culture
Authors: Yongkhamcha Butsara , Buddhakala Nopparat
Published: March 2023

The objective of this work was to investigate the potential of pumpkin rind and seed on antidiabetic and anti-inflammatory activities and the underlying mechanism. Therefore, this work was carried out to determine the antidiabetic activity using inhibitory activities of pumpkin rind and seeds extracts on α - glucosidase and the anti-inflammatory activity via inhibitory activity on nitric oxide production. And also, the potential of the pumpkin rind and seeds on culture of Chlorella ellipsoidea was determined. Determination of inhibitory activity on α - glucosidase was performed using α - glucosidase assay, while the Griess assay was employed for the inhibition on Nitric oxide (NO) -production. The pumpkin seed extract inhibited α - glucosidase more potent than the pumpkin rind extract (IC50 of 321.36 vs. 326.18 µg/mL). However, the activities of the extracts were less potent than that of Acarbose (IC50 of 317.26 µg/mL). Application of the extracts at the highest concentration, 500 µg/mL, the pumpkin seed extract displayed the inhibition of NO production higher than the pumpkin rind extract did (18.01 ± 1.57 % vs. 14.99 ± 1.94 %). Study on the effects of pumpkin rind and seeds on C. ellipsoidea culture revealed that the optimum media was the 7th medium (NPK+ mixture of pumpkin seed water and Blue-Green Medium (BG-11), 1:4) which generated the growth of C. ellipsoidea for 28 days with the Optical Density (OD) value of 1.43 ± 0.01 followed by BG-11 medium OD value of 1.41 ± 0.02) and the 3rd medium (NPK+ mixture of pumpkin rind water and BG-11, 1:1, OD value of 1.32 ± 0.01), respectively. The chemical contents of C. ellipsoidea cultured in 7th medium contained 54.25 ± 0.06 % protein, 15.95 ± 0.87 % carbohydrates, 9.35 ± 0.05 % fat, and 20.30 ± 0.33 % ash, meanwhile 53.37 ± 0.77 % protein, 12.83 ± 0.62 % carbohydrates, 17.80 ± 0.23 % fat, and 23.30 ± 1.33 % ash in the 3rd medium. The results obtained from this investigation indicate that pumpkin rind and seeds not only can be exploited for the antidiabetic and anti-inflammatory components but also can be applied instead of the conventional medium for the culture of C. ellipdoidea. Therefore, bio-waste from pumpkin could be potentially utilized as the source of natural antidiabetic inhibitors, anti-inflammatory drugs and the effective components of C. ellipdoidea culture media.
HIGHLIGHTS

The pumpkin rind and seed extracts possess antidiabetic and anti-inflammatory properties
The extracts from pumpkin rind and seeds exhibit antidiabetic activity via α- glucosidase inhibition
The extracts from pumpkin rind and seeds display anti-inflammatory activity by inhibiting on nitric oxide (NO) production
The extracts from pumpkin rind and seeds could be potentially utilized as a source of natural antidiabetic inhibitors and anti-inflammatory drugs
The bio-waste, pumpkin rind and seeds, could be used as the effective components of ellipdoidea culture medium

GRAPHICAL ABSTRACT
The scientistic worldview and its relationships with fear of COVID, conspiracy beliefs, preventive behaviors, and attitudes towards vaccines during the COVID-19 pandemic in a Polish sample
Authors: Jach Łukasz
Published: March 2023

Background

The scientistic worldview is characterized by the tendency to justify beliefs and behavior with scientific findings and to function on the basis of theorems and opinions formulated by scientists. The aim of this study was to test whether the attitudes typical for the scientistic worldview could be related to beliefs and behaviors that may reduce the risk of contracting and spreading COVID-19.

Participants and procedure

The study was conducted on a Polish sample of 1286 participants, using an online survey platform. Participants were asked to complete questionnaires to measure attitudes towards vaccines on COVID-19, the scientistic worldview, fear of COVID, conspiracy beliefs about the COVID-19 pandemic, and preventive behaviors undertaken. Participants were also asked about their personal experiences with the pandemic.

Results

The study showed that the scientistic worldview was associated with a higher fear of COVID, a higher level of con-tainment-related behavior, a lower level of conspiracy beliefs about the COVID-19 pandemic, and more positive atti-tudes towards vaccination against COVID-19. A structural model of relations between the studied variables turned out to be very effective and explained 51% of the variance of containment-related behavior and 63% of the variance of attitudes towards the COVID-19 vaccines.

Conclusions

The study found that preventive behaviors and attitudes towards vaccination against COVID-19 were weakly related to personal experiences during the pandemic but significantly correlated with psychological variables. The results suggest that very positive, scientistic attitudes towards science may be related to higher adherence to science-based public health recommendations.
The association between affective temperaments and insomnia as mediated by satisfaction with life: a cross-sectional study
Authors: Włodzimierz Oniszczenko
Published: March 2023

Background

The primary objectives of this study were to examine whether affective temperaments are associated with satisfac-tion with life; to determine whether satisfaction with life can mediate the relationship between affective tempera-ments and insomnia; and to reaffirm the relationship between affective temperaments and insomnia. We hypothe-sized that affective temperaments were associated directly and indirectly via satisfaction with life with insomnia.

Participants and procedure

A total of 497 participants aged 18 to 67 years, including 435 women and 62 men, were recruited from the general population via an online recruitment platform. We used the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego Autoquestionnaire to evaluate affective temperaments and the Satisfaction with Life Scale to assess satis-faction with life. The Athens Insomnia Scale was used to assess participants’ level of insomnia symptoms.

Results

Depressive, cyclothymic, irritable and anxious temperaments correlated positively with insomnia symptoms, but hyperthymic temperament correlated negatively with insomnia symptoms. Satisfaction with life correlated negative-ly with insomnia symptoms. Hyperthymic temperament correlated positively with satisfaction with life, but depres-sive, cyclothymic, irritable and anxious temperaments correlated negatively with satisfaction with life. Hierarchical regression analysis indicated that 30% of the variance in insomnia symptoms was attributable to satisfaction with life level and the presence of cyclothymic and anxious temperaments. The mediation analysis suggested a significant indirect effect of cyclothymic and anxious temperaments on insomnia through satisfaction with life as a mediator between affective temperaments and insomnia.

Conclusions

Cyclothymic and anxious temperaments can influence the symptoms of insomnia directly and indirectly as mediated by satisfaction with life.
Methods Used in Confirmation of the Position of Nasogastric Feeding Tubes: Advantages and Limitations
Authors: Pars Hatice
Published: March 2023

Confirmation of the placement of the nasogastric tube is essential to ensure safe feeding without the risk of aspiration, pneumonia, and pneumothorax that may occur due to incorrect placement of the nasogastric tube. The risk of incorrect placement of the nasogastric tube may increase in the high-risk patient group, especially with some factors such as decreased consciousness, weak gag reflex, intubation, mechanical ventilation, and sedation. In addition to the problems that may occur during the initial placement of the nasogastric tube, displacement of the nasogastric tube may occur during the enteral feeding process. For this reason, tube placement should be checked regularly in order to minimize the complications of enteral nutrition. Although there are some advantages and limitations of the methods used to determine the location of the nasogastric tube, it is seen that there is no standard practice on this subject in clinics. The aim of this review is to summarize the commonly used methods for the initial placement of the nasogastric tube and the confirmation of the tube position during the feeding process and to summarize the advantages and limitations of these methods.
Validación de instrumentos para medir percepciones y comportamientos vinculados al sars-cov 2 en bolivia
Authors: Vargas-Chiarella Carlos Ricardo , Vera-Zambrana Angela Marion
Published: March 2023

Introducción: La pandemia COVID-19 ha sido un evento misceláneo, que afectó la percepción de los individuos como sujetos y las relaciones intersubjetivas, el estado como referente de representación/identidad se vio trastocado, y las condiciones de salud/enfermedad se externalizaron como resultados de las relaciones sociales, Los trastornos del estado de ánimo, el marcaje social y el miedo son efectos predecibles, por lo que conocer instrumentos validados disponibles para estudiarlos cobra relevancia. Objetivo principal: Evaluar la validez del DASS-21, FCV-19S y el cuestionario de estigma COVID-19 en el medio urbano boliviano. Método: Este trabajo examina la validez de tres instrumentos: DASS-21, FCV-19S y una traducción al español del cuestionario COVID-19 Stigma, para el contexto urbano boliviano, en un estudio piloto en la ciudad de Cochabamba compuesto por 30 sujetos aleatorizados, basado en el alfa de Cronbach y el análisis factorial. Resultados: Después de considerar el contexto, se encontró consistencia interna y validez en el cuestionario DASS-21 y Estigma, bajo condiciones sociodemográficas similares a las del piloto. Conclusión: los instrumentos validados son aptos para su aplicación en Bolivia, con las consideraciones adecuadas para optimizar su efectividad.
CLASSIFICATION OF DISEASES AND PESTS OF MAIZE USING MULTINOMIAL LOGISTIC REGRESSION BASED ON RESAMPLING TECHNIQUE OF K-FOLD CROSS-VALIDATION
Authors: Resti Yulia , Saraswati Desi Herlina , Zayanti Des Alwine , Eliyati Ning
Published: March 2023

Some of the obstacles in the cultivation of maize that cause low productivity of maize yields are diseases and pests. Early detection of maize diseases and pests is expected to reduce farmer losses. A system for the early detection of diseases and pests can be created by classifying them based on digital images. This study aimed to classify maize diseases and pests using multinomial logistic regression. The model and testing resampling were based on resampling technique of k-fold cross-validation. The research data was obtained from the RGB color feature extraction process for each object in each class of diseases and pests of corn. The results showed that the classification into seven classes using five folds had an accuracy rate of 99.85%, macro precision of 98.59%, and macro recall of 98.15%.
AN IMPROVED CHANNEL SELECTION ALGORITHM (ICSA) FOR SPECTRUM HAND-OFF IN COGNITIVE RADIO AD HOC NETWORK
Authors: Tekanyi M. S. , Orokpo James A. , Abdulkareem H. A. , Alexander Tobore O.
Published: March 2023

The exponential growth in wireless communication technology has led to spectrum scarcity. Because of this, the world has moved from Fixed Spectrum Allocation (FSA)  Strategy to Dynamic Spectrum Allocation (DSA) Strategy. Cognitive Radio (CR) is a rapidly growing technique that makes use of DSA, where the licensed users, otherwise known as Primary Users (PUs), share their channel with the unlicensed users, known as Secondary Users (SUs). The SUs can use the PUs channel when they are not being used for transmission, but they have to vacate to another vacant channel when the PUs arrive in their channel. Switching to another vacant channel on the arrival of the PUs to their channels is known as spectrum hand-off. Finding another suitable vacant channel for the SUs to continue their interrupted transmission is challenging. Several researchers have used different techniques to address the challenge of target channel selection for spectrum hand-off by considering channel occupancy alone. Still, they suffer challenges like the high number of spectrum hand-offs, high delay, and low throughput. Therefore, this research focuses on developing an Improved Channel Selection Algorithm (ICSA) that considers channel occupancy serially with signal quality requirements for selecting a particular backup channel for spectrum hand-off. The simulation was carried out using Network Simulator (NS), and the results were plotted using Matlab. The results showed that the ICSA had better performance when compared with the Novel Proactive Hand-off Scheme (NPHS) regarding the number of hand-offs, average delay, and average throughput.
VLIV PŘÍČNÉHO ROZMĚRU PŘÍTOKOVÉ ŠACHTY NA PŘEPAD PŘES PŘELIV SE ŠIROKOU KORUNOU
Authors: Major Jakub
Published: March 2023

Ve vodohospodářské praxi se často využívají přelivy se širokou korunou, u kterých není použito přítokové koryto, ale přítoková šachta. V případě přítokové šachty není známý vliv rychlostní výšky na kapacitu přelivu, zvláště pak při různých výškách příčného profilu šachty. Dále pak není známý průběh hladiny nad šachtou a korunou přelivu a jeho relativní vyjádření. Článek popisuje experiment se svislou přítokovou šachtou, na základě kterého byl průběh hladiny nad šachtou a korunou přelivu v relativním vyjádření stanoven.
MÍRA ZPĚTNÉHO OSTŘIKU JAKO FUNKCE DOPADOVÉHO ÚHLU
Authors: Nehudek Adam , Šulc Jan
Published: March 2023

Článek pojednává o stanovení závislosti míry zpětného ostřiku na odpadovém úhlu vodního proudu vystupujícího z rozstřikovacího uzávěru pomocí 2D numerického výsekov.ho modelu v programu FLOW-3D.
ASSESSMENT OF EXTERNAL INFLUENCES ON JOINT QUALITY OF ROOF WATERPROOFING FOIL BASED ON MPVC
Authors: Petro Marek , Ivanko Matej
Published: March 2023

The statement deals with the research of how the technology used for single ply roofing membranes based on mPVC can influence the final quality of its joints. It is clear that any roofing company working with waterproofing membranes has its own processes and usage for waterproofing membranes. Besides, not all of the articles study all directions set by manufacturers. Depending on this, if we don’t take into account the quality of material and other factors, the quality and final lifetime of the single ply roof can vary. The article includes a description of how was the research was made, processes used and the conclusions which were found during the research.
LCA STUDY OF ENVIRONMENTAL IMPACTS OF WWTP
Authors: Csicsaiová Réka , Holubec Michal , Gregušová Veronika , Škultétyová Ivona
Published: March 2023

This article reviews the environmental impacts of the wastewater treatment plant. The wastewater treatment plant is evaluated using a simplified LCA analysis, as only negative environmental impacts are assessed. The analysis takes place in 4 phases, which is interconnect and interact with another. It is important to correctly specify input data such as a functional unit, reference flow, system boundaries. Subsequently, a characterization model of the product system is created, what presents the wastewater treatment process with all input parameters.
Sengketa Lingkungan Hidup (Analisis Kasus Pencemaran Limbah Industri PT. Marimas di Semarang Terhadap Sumber Air Warga
Authors: Anindito Teguh , Hariadi Wahyu , Kusumawardana Haris
Published: March 2023

Water pollution is the entry or inclusion of organisms, substances, energy and other components into the environment by human activities that exceed the established environmental quality standards. Disposal of remaining business activities in the form of waste by PT. Marimas going to the river is a form of environmental pollution, incidents of sewage pipes leading to leaking waters, causing the residents' springs around the factory to be polluted and unable to be utilized. Therefore, legal firmness is needed against perpetrators of pollution aimed at creating justice, benefits and legal certainty. Law on Environmental Management and Protection No. 32 of 2009 (hereinafter referred to as UUPPIH), as a functional law, divides environmental enforcement into three types: administrative, civil and criminal.

Keyword: PT Marimas, water pollution, industrial waste

Abstrak. Pencemaran air merupakan masuknya atau dimasukkannya organisme, zat, energi, dan komponen Iain ke Iingkungan hidup oIeh kegiatan manusia yang meIampaui baku mutu Iingkungan yang ditetapkan”. Pembuangan sisa kegiatan usaha berupa Iimbah oIeh PT. Marimas ke sungai adaIah bentuk pencemaran Iingkungan, insiden saIuran pipa Iimbah yang menuju ke perairan bocor sehingga menyebabkan sumber mata air warga di sekitar pabrik tercemar dan tidak bisa dimanfaatkan. OIeh karenanya, diperIukan ketegasan hukum terhadap peIaku pencemaran bertujuan untuk menciptakan keadiIan, kemanfaatan dan kepastian hukum.Undang-Undang PengeIoIaan dan PerIindungan Iingkungan Hidup No. 32 Tahun 2009 (seIanjutnya disebut UUPPIH), sebagai peraturan perundang-undangan fungsionaI, membagi penegakan Iingkungan hidup menjadi tiga jenis: administratif, perdata dan pidana.

Kata Kunci: PT Marimas, pencemaran air, Iimbah industri