bluuebunny/crossref_metadata_2025 huggingface dataset:
CONSUMERS’ PERCEPTION OF SUSTAINABLE PACKAGING IN THE FOOD INDUSTRY
Authors: Anquez Elsa , Raab Katharina , Cechella Felipe Schneider , Wagner Ralf
Published: May 2022

Consumers evaluate products and make purchasing decisions based on packaging and its sustainable aspects. This research investigated how different packages and their quality, eco-friendliness, expensiveness, and convenience affected consumers’ intentions to purchase. Our sample comprised 299 French consumers of muesli cereals. We conducted an online choice experiment to analyze and measure consumers’ perception of sustainable packaging, comparing three distinct experimental groups. Findings revealed that quality and environmental friendliness impact purchase intentions. Price sensitivity and environmental behavior showed to have moderation effects in the proposed research model. The reusable container is perceived as more expensive and less convenient when compared to other packaging types. We contribute to the existing literature in the food industry by providing additional insights into consumers’ recognition processes in identifying sustainable packaging.
Parallèle entre roman historique et roman jeunesse: enjeux narratifs et pragmatiques
Authors: Beaudoin Karine
Published: May 2022

Partant des observations relevées par Marilyn Randall dans le dernier chapitre de Les femmes dans l’espace rebelle (2013), l’article propose une analogie du roman historique et du roman jeunesse, suivie d’une réflexion sur la représentation de la marginalité féminine dans une littérature destinée à un jeune lectorat. Au-delà d’une visée commune, soit instruire et divertir, de nombreux aspects narratifs et réceptifs unissent ces deux sous-genres romanesques et peuvent expliquer le traitement réservé à l’imaginaire de la marginalité, plus spécifiquement de la marginalité des femmes et des filles.
Intraoperative BIS monitoring can predict the occurrence of EEG suppression and improve the operation quality
Authors: Zhao Jindi , An Xingwei , Yu Wenli , Weng Yiqi , Sheng Mingwei , Jia Lili , Sun Ying , Du Hongyin , Ming Dong
Published: May 2022

Recent years, researches on diagnosis of anesthesia status and postoperative recovery based on electroencephalogram (EEG) signals have become increasingly popular. Bispectral index (BIS) is the earliest and most effective indicator for monitoring the depth of clinical anesthesia, and the waveform of intraoperative EEG can be displayed in real time. Excessive anesthesia and other conditions will cause burst suppression (BS) of intraoperative EEG, which will prolong the operation time and ICU stay time, and increase the incidence of postoperative delirium. This study analyzes the changes of intraoperative BIS monitoring on real-time EEG waveform and spectrogram, the results showed that BIS can predict the occurrence of EEG BS and then reduce the operation time and the incidence of postoperative delirium through rational use of intraoperative drugs.
Relationship Between Inflammatory Bowel Disease and Erythema Nodosum and Psoriasis: Using Mendelian Randomization
Authors: Jianhua Lu , Danna Liang , Shengsheng Zhao , Xiaoxiao Shao , Chuyuan Ye , Bozhen Chen , Jiangnan Chen , Pihong Li , Hao Wu , Weijian Sun
Published: May 2022

Background
Erythema nodosum and psoriasis are two prevalent extraintestinal manifestations of inflammatory bowel disease (IBD). Erythema nodosum usually appears before or after the onset of IBD. Therefore, it has to be studied whether there is an association between erythema nodosum, psoriasis, and IBD, and their causal relationship remains to be explored.
Methods
To choose acceptable instruments, single nucleotide polymorphisms (SNPs) strongly associated with exposure, a series of quality control measures were used in our study. We utilized several robust analytical methods (inverse-variance weighted, weighted median, and MR-Egger regression) based on different assumptions of two-sample MR analysis to obtain more robust and reliable conclusions. To assess the horizontal pleiotropy, heterogeneities, and stability of these genetic variants on erythema nodosum, MR-Egger intercept test, Cochran's test, and "leave-one-out" sensitivity analysis were performed.
Results
Our two-sample Mendelian randomized analysis, exposure GWAS aggregate, and GWAS aggregate results showed a positive association between IBD and erythema nodosum and psoriasis, consistent with many published observational studies, but our calculations revealed no statistical difference between the two.
Conclusion
MR estimations showed no significant association between inflammatory bowel disease and erythema nodosum (OR = 1.069; P > 0.05) and psoriasis (OR = 1.014; P > 0.05). Therefore, further research is required to understand better the relationship between IBD and erythema nodosum and psoriasis.
A rare case of cervical squamous cell carcinoma combined with sinonasal inverted Papilloma: A case report
Authors: Hou Xiaoyu , Peng Chunrong , Zhang Guonan , Wang Dengfeng
Published: May 2022

Background: Cervical cancer is the fourth most common malignancy in women worldwide, and sinonasal inverted papilloma (SIP) is a rare benign sinus tumor and has the characteristics of destructive growth pattern, high recurrence rate and easy canceration. Cervical squamous cell carcinoma (SCC) combined with SIP has not been reported so far. Case Presentation: A 55-year-old woman was diagnosed with cervical SCC in our center and treated with concurrent radiochemotherapy. During the follow-up period, SIP was found twice and both underwent endoscopic left nasal tumor resection. The clues that the diseases were found were the abnormal rise of squamous cell carcinoma antigen (SCCA). SCCA level decreased to normal after operations.Discussion and Conclusion: (1) when the cervical lesions have resolved satisfactorily but the SCCA is still high, other sites should be promptly investigated for the cause, which may lead to earlier detection and earlier treatment of SIP. (2) Combined with the literature, we recommend that SCCA can be used as a routine monitoring index for SIP. If available, a combination of SCCA1 and SCCA2 can be tried for further judgement. (3) For SIP with a high recurrence rate, can anti-HPV treatment be taken after operation to reduce the risk of recurrence?
Genes whose gain or loss-of-function changes type 1, 2A, 2X or 2B muscle fibre proportions in mice: A systematic literature review
Authors: Kuhnen Gabryela , Russomano Tiago Guedes , Murgia Marta , Pillon Nicolas J. , Schönfelder Martin , Wackerhage Henning
Published: May 2022

Background: Adult muscle fibres are classified as type 1, 2A, 2X, and 2B muscle fibres based on the expression of the dominant myosin heavy chain isoform. Muscle fibre-specific gene expression and muscle fibre types change during development and in response to changes in contractile activity such as exercise, chronic electrical stimulation versus inactivity or denervation. Methods: To identify genes whose gain or loss-of-function changes type 1, 2A, 2X or 2B muscle fibre proportions in mice, we conducted a systematic review following the 2020 PRISMA guidelines and the PICO framework.Results: We identified 25 “muscle fibre genes” (Akirin1, Bdkrb2, Bdnf, Camk4, Ccnd3, Cpt1a, Epas1, Esrrg, Foxj3, Foxo1, Il15, Mapk12, Mstn, Myod1, Ncor1, Nfatc1, Nol3, Ppargc1a, Ppargc1b, Sirt1, Sirt3, Thra, Thrb, Trib3, Vgll2) whose gain or loss-of-function changes type 1, 2A, 2X or 2B muscle fibre proportions in mice. The fact that 15 of the 25 muscle fibre genes are transcriptional regulators suggests that muscle fibre-specific gene expression is primarily regulated transcriptionally. Muscle fibre genes such as Ppaargc1a and Vgll2 increase or Mstn decrease their expression after exercise, respectively, suggesting that this contributes to muscle adaptation to exercise. Finally, there are many known DNA sequence variants of muscle fibre genes suggesting that this contributes to the large variation of muscle fibre percentages in humans. Conclusion: Muscle fibre genes are a set of genes that often regulate gene expression and where DNA variants are likely to change human muscle fibre distribution.
Nationally validating the core competency evaluation instrument for gerontological nurse specialists: based on exploratory and confirmatory factor analysis
Authors: Chen Hongxiu , Pu Lihui , Hu Xiuying , Chen Qian , Huang Zhaojing , Wang Fang , Wang Guan , Bai Chunlan , Cheng Linan , Shi Hongrui
Published: May 2022

Objectives: This study aims to further test the psychometric properties of the core competency evaluation instrument for gerontological nurse specialists nationwide and to optimize it.Design: Cross-sectional studySettings and Participants: This study was conducted on gerontological nurse specialists trained at 13 province-level or above training organizations in China.Methods: Online questionnaires were adopted to collect data from March 2019 to January 2020. The exploratory and confirmatory factor analyses were applied to revise and cross-validate the instrument.Results: Twenty items were excluded from the original scale, and nine factors were extracted from the revised scale by exploratory factor analysis. Of nine extracted factors, two (professional self-identification and learning enthusiasm), five (clinical nursing skill, communication and management skill, professional development skill, legal/ethical practice skill, and research/analysis decision-making skill), and two factors (professional knowledge and basic knowledge) were extracted from Attitude, Skill, and Knowledge subscale, respectively. 87.02%, 81.70%, and 81.70% of the total variances were explained respectively by factors extracted from these three subscales, which were much higher than those of the original version scale (i.e., 68.58%, 69.60%, and 75.87% respectively). The revised scale was cross-validated by confirmatory factor analysis, which showed good model fitness in all three subscales, that is, χ2/df < 3, SRMR ≤ 0.05, RMSEA ≤ 0.05, GFI, AGFI, IFI, TLI, and CFI > 0.9. The Cronbach’s α coefficients of nine factors ranged from 0.91 to 0.98. The retest reliability was 0.87.Conclusion: The factor structure of the core competency evaluation instrument for gerontological nurse specialists was more stable and concise after modification. The revised scale could be preliminarily used nationwide as it has excellent reliability and validity. However, it is also necessary to make further adjustments.
Risk Factors for Insufficient Reduction After Short-Segment Posterior Fixation for Thoracolumbar Burst Fractures Does the Interval from Injury Onset to Surgery Affect Reduction of Fractured Vertebrae?
Authors: Aono Hiroyuki , Takenaka Shota , Okuda Akinori , Kikuchi Takeshi , Takeshita Hiroshi , Nagata Keiji , Ito Yasuo
Published: May 2022

Background: Many surgeons have encountered patients who could not immediately undergo surgery to treat spinal fractures because they had associated injuries and/or because a complete diagnosis was delayed. For such patients, practitioners might assume that delays could mean that the eventual reduction would be insufficient. However, no report covered risk factors for insufficient reduction of fractured vertebra including duration from injury onset to surgery. The purpose of this study is to investigate the risk factors for insufficient reduction after short-segment fixation of thoracolumbar burst fractures.Methods: Our multicenter study included 253 patients who sustained a single thoracolumbar burst fracture and underwent short-segment fixation. We measured the local vertebral body angle (VBA) on roentgenograms, before and after surgery, and then calculated the reduction angle and reduction rate of the fractured vertebra by using the following formula:[(Preoperative VBA – Postoperative VBA) / Preoperative VBA] × 100A multiple logistical regression analysis was performed to identify risk factors for insufficient reduction. The factors that we evaluated were age, gender, affected spine level, time elapsed from injury to surgery, inclusion of vertebroplasty with surgery, load-sharing score (LSS), AO classification (type A or B), preoperative VBA, and the ratio of canal compromise before surgery.Results: There were 140 male and 113 female patients, with an average age of 43 years, and the mean time elapsed between injury and surgery was 3.8 days. The mean reduction angle was 12°, and the mean reduction rate was 76%. The mean LSS was 6.4 points. Multiple linear regression analysis revealed that a higher LSS, a larger preoperative VBA, a younger age, and being female disposed patients to having a larger reduction angle and reduction rate. The time elapsed from injury to surgery had no relation to the quality of fracture reduction in the acute period.Conclusions: Our findings indicate that if there is no neurologic deficit, it is not necessary to hurry surgical reduction of fractured vertebrae in the acute phase.
Comparision of the scoring systems to predict clinical outcomes in elderly patients with biliary pancreatitis: a cross-sectional study
Authors: İNAN OSMAN , ACEHAN MUHAMMED FATİH , ŞAHİNER ENES SEYDA , ASLAN MERYEM , ALTIPARMAK EMİN , ATES İHSAN
Published: May 2022

Background
The issue of which scoring system is appropriate in elderly patients with acute biliary pancreatitis is an ongoing debate. We aimed to compare the efficiency of four existing scoring systems in predicting clinical outcomes in the elderly with acute biliary pancreatitis.
Methods
The study included patients aged 60 years and older with a diagnosis of acute biliary pancreatitis. Clinical findings, routine laboratory examinations, and imaging findings were retrospectively accessed through the hospital information system and reviewed. Then, the efficacy of Ranson, Bedside Index of Severity in Acute Pancreatitis (BISAP), Glasgow-Imrie, and Acute Physiology and Chronic Health Evaluation (APACHE) II scoring systems in predicting mortality, severity, organ failure, complications, intensive care unit (ICU) admission, and prolonged hospital stay (PHS) were compared.
Results
The Ranson score was compared with three other existing scoring systems in primary and secondary outcomes in 364 eligible patients. The area under the curve (AUC) values of the Ranson, BISAP, Glasgow, and APACHE II scores were 0.787 (95% CI: 0.649–0.925), 0.856 (95% CI: 0.784–0.929), 0.908 (95% CI: 0.854–0.961), and 0.836 (95% CI: 0.702–0.971) for mortality. Although the AUC of the Ranson score for mortality was lower than that of the other scores, no significant difference was found in pairwise comparisons with the other three scores (p > 0.05 for all).
Conclusion
The Ranson scoring system was the weakest among the assessed scoring systems in predicting clinical outcomes in elderly patients with biliary pancreatitis.
MCUR1 is a marker for the progression and prognosis of breast cancer
Authors: Che Xuchun , Wang Qing , Zhang Bo
Published: May 2022

The uptake of Ca2+ in mitochondria depends on the mitochondrial calcium uniporter and its regulatory subunits, such as mitochondrial calcium uptake 1 and mitochondrial calcium uniporter regulator 1(MCUR1). We developed a prognostic biomarker gene network based on MCUR1 gene to provide survival risk prediction for breast cancer. The Gene Expression Profiling Interactive Analysis was developed to analyze survival rate of breast cancer patients in the MCUR1 high and low expression group from the combined data of The Cancer Genome Atlas and The Genotype-Tissue Expression. The immune status including immune cell infiltration ratio and checkpoints have been explored. The significantly enriched KEGG pathway and GO terms in two groups have been also studied. A co-expression analysis was generated for the connected gene network for MCUR1. It can be shown here the low expression of MCUR1 is closely related to the development and prognosis of breast cancer. From the immune cell infiltration ratio analysis, there is a significant difference in the infiltration degree of macrophages M1 and T cells CD8 between MCUR1 high and low expression groups. Meanwhile, the expression of 6 checkpoints in low expression group of MCUR1 was significantly lower than that in high expression group of MCUR1(P<0.05). The glycine serine and threonine metabolism related pathway in KEGG enrichment analysis and oxidoreductase activity acting on the CH_NH2 group of donors oxygen as acceptor, negative regulation of interleukin 10 production, regulation of tolerance induction in GO terms are activated in MCUR1 high expression group. 8 genes show a close connection to MCUR1 from co-expression network study. This study has explored a potential prognostic biomarker and established a MCUR1 based prognostic prediction model for breast cancer, which provides a valuable reference for future clinical research.
Time-Domain Anti-Interference Method for Ship Radiated Noise Signal
Authors: YiChen Duan , Xiaohong Sheng , Haiyan Wang
Published: May 2022

ship radiated noise signal is one of the important ways to detect and identify ships, and emission of interference noise to shield its own radiated noise signal is a common countermeasure. In this paper, we try to use the idea of signal enhancement to enhance the ship radiated noise signal with extremely low signal-to-noise ratio, so as to achieve anti-explosive signal interference. We propose a signal enhancement deep learning model to enhance the ship radiated noise signal by learning a mask in the temporal domain. Our approach is an encoder-decoder structure with U-net. U-net consists of 1d-conv with skip connection. In order to improve the learning ability of the model, we directly connect the U-net in series. In order to improve the learning ability of the model's time series information, we avoid deep learning paradigms such as lstm or RNN with high computational complexity. The Transformer attention mechanism is adopted to make the model have the ability to learn temporal information. We propose a combine Loss function for SI-SNR and mean squared error in time-domain. Finally, we use the actual collected data to conduct experiments. It is verified that our algorithm can effectively improve the signal-to-noise ratio of the ship radiated noise signal to 2dB under the extremely low signal-to-noise ratio of -20dB to -25dB.
Towards Ensemble-Based Kilometer-Scale Climate Simulations over the Third Pole Region
Authors: Prein Andreas F. , Ban Nikolina , Ou Tinghai , Tang Jianping , Sakaguchi Koichi , Collier Emily , Jayanarayanan Sanjay , Li Lu , Sobolowski Stefan , Chen Xingchao , Zhou Xu , Lai Hui-Wen , Sugimoto Shiori , Zou Liwei , Hasson Shabeh ul , Ekstrom Marie , Pothapakula Praveen Kumar , Stuart Romilly , Steen-Larsen Hans Christian , Leung Ruby , Belusic Danijel , Kukulies Julia , Curio Julia , Chen Deliang
Published: May 2022

The Tibetan Plateau and its surrounding mountains have an average elevation of 4,400 m and a glaciated area of ~100,000 km 2 giving it the name "Third Pole (TP) region". The TP is the headwater of many major rivers in Asia that provide fresh water to hundreds of millions of people. Climate change is altering the energy and water cycle of the TP at a record pace but the future of this region is highly uncertain due to major challenges in simulating weather and climate processes in this complex area. The Convection-Permitting Third Pole (CPTP) project is a Coordinated Regional Downscaling Experiment (CORDEX) Flagship Pilot Study (FPS) that aims to revolutionize our understanding of climate change impacts on the TP through ensemble-based, kilometer-scale climate modeling. Here we present the experimental design and first results from multi-model, multi-physics ensemble simulations of three case studies. The five participating modeling systems show high performance across a range of meteorological situations and are close to having ''observational quality'' in simulating precipitation and near-surface temperature. This is partly due to the large differences between observational datasets in this region, which are the leading source of uncertainty in model evaluations. However, a systematic cold bias above 2,000\,m exists in most modeling systems. Model physics sensitivity tests performed with the Weather Research and Forecasting (WRF) model show that planetary boundary layer (PBL) physics and microphysics contribute equally to model uncertainties. Additionally, larger domains result in better model performance. We conclude by describing high-priority research needs and the next steps in the CPTP project.
Patient-derived xenograft mouse model for personalized treatment in patients with multiple myeloma
Authors: Li Jun , Shi Zhangzhen , Wen Danyi , Bi Lintao
Published: May 2022

Background: This study aimed to establish patient-derived xenografts (PDX) models of multiple myeloma and to evaluate the feasibility of using the PDX model to test chemotherapy responsiveness. Methods: Three patients with multiple myeloma were enrolled. Fresh multiple myeloma cells isolated from bone marrow or ascites samples were inoculated subcutaneously into flanks of NCG mice. Then, engrafted tumor pieces were inoculated into flanks of NCG mice. When tumor volumes reached 100–300 mm3, the mice were divided into groups to receive corresponding chemotherapy treatments. The volume and weight of tumors were quantified.Results: The first patient responded well to BCD (bortezomib, dexamethasone, and cyclophosphamide) chemotherapy, so did the patient’s PDX model. The second patient did not response to BCD, nor the patient’s PDX model. The third patient had a transient remission after treated with BCD, MPT (melphalan, prednisone, and thalidomide), or ILD (ixazomib, lenalidomide, and dexamethasone) regimens. The third patient’s PDX model, at least partially, responded to these regimens. Conclusion: Drug responses of the patients with multiple myeloma and their PDX mouse models were consistent. The PDX mouse model is a valid experimental platform that can be utilized in a clinical setting to select personalized therapies for patients with multiple myeloma.
Physiological and Biochemical Effects of Heavy Metals on Wheat Seedlings in Northern Xuzhou
Authors: Luan Huijun , Xiao Xin , CONDE Sékou Mohamed , Wang Li , Xing Mingjie , Liang Yan , Lu Yin
Published: May 2022

Storage and transportation of coal，and operation of the coal fired power plant produce a large amount of waste water, gas and solid waste, which may lead to enhanced levels of heavy metals in overlapped areas of farmland and coal resources (OAFCR) environment. A field experiment was conducted to explore heavy metal (Cr, Cd, Cu, Zn, Pb and As) stress in environment on wheat seedlings (AK-58) growing in OAFCR region (north of Xuzhou) and the area in the southern suburb of Xuzhou. The results show that (1) Compared with the southern suburb of Xuzhou, the biomass (fresh and dry weight) of wheat was significantly lower in OAFCR. (2) The activities of photosynthetic enzymes and POD were significantly lower in OAFCR, but the activities of SOD and CAT were higher, compared with the area in the southern suburb of Xuzhou. (3)The content of Cr,Cd,Pb,Zn in shoot and Cr,Cd,Pb,Zn,Cu in root of wheat growing in OAFCR were all significantly higher than in the southern suburb of Xuzhou; Translocation factors (TF) of elements（except Cd） were lower in OAFCR . The BCF values of heavy metals in wheat in OAFCR were also exceed that in the southern suburb of Xuzhou by approximately 199% (Cd), 110% (Pb), 61% (Cr), 37% (Zn), 27% (Cu) and 7% (As) respectively. (4)The subcellular analysis showed that the Pb, Cu, Cd, Zn and Cr absorbed by wheat were stored primarily in the cell walls and the soluble fractions. Both the contents of Cu , Cr in wheat cell walls and the contents of Pb, Cu and Zn in soluble components in OAFCR were all significantly higher than in the southern suburb of Xuzhou
Superlubricity under ultrahigh contact pressure enabled by self-assembled fluorinated azobenzene layers
Authors: Xue Dandan , Ma Liran , Wen Shizhu , Luo Jianbin
Published: May 2022

Extensive efforts have been made to pursue an ultralow-friction state, which is known as superlubricity, with promising applications in many fields, such as mechanical and biomedical engineering. The load capacity of superlubricity has been considered to be crucial for industrial applications. Here, we report superlubricity under ultrahigh contact pressure by building a novel self-assembled fluorinated azobenzene layer on an atomically smooth highly oriented pyrolytic graphite (HOPG) surface. Sliding friction coefficients could be as low as 0.0005 or even lower under a contact pressure of up to 4 GPa. This ultralow-friction is attributed to molecular fluorination, which significantly weakens the intermolecular force between the close-packed fluorine atoms arrayed between the HOPG surface and the silicon atomic force microscopy (AFM) probe. This work provides a new approach to solid superlubricity under relatively high contact pressure, which might has great potential application value in the future.
Elucidation of peripheral nerve myelination by bimodal waveform analysis in the pediatric population
Authors: Okuma Aiko , Nakamura Tomohiko , Katsuno Masahisa , Matsushita Tadashi
Published: May 2022

Purpose
As the myelin sheath of the peripheral nerves is immaturely developed in children, a bimodal waveform may be evoked when sensory nerve conduction studies are performed in them. However, there has been no study regarding the relationship between age and the frequency of appearance of the bimodal waveform or the intervertex latency. Herein, we examined how the bimodal waveform changes with age.
Methods
A total of 218 sensory nerves (109 median and 109 ulnar nerves) in 86 children (0 to 15 years old) were analyzed. The frequency of the bimodal waveform and the distance-corrected intervertex latency were examined with antidromic sensory nerve conduction studies of the upper limbs on proximal stimulation.
Results
The frequency of bimodal waveforms and distance-corrected intervertex latency decreased with age. Analysis of the slope line of the scatter plot demonstrated that the bimodal waveform was present until the age of 15–16 years.
Conclusion
The bimodal waveform of sensory nerves faded with growth. Given that development-associated temporal dispersion is considered to be the cause of the differences in the bimodal waveform, our results indicate that the myelin sheath in peripheral nerves continues to develop until approximately 15–16 years.
Assessment of Resected Liver Fibrosis Stages by Preoperative/Intraoperative Needle Biopsy among Hepatocellular Carcinoma Patients
Authors: Kuramitsu Kaori , Fukushima Kenji , Yano Yoshihiko , Itoh Tomoo , Kido Masahiro , Komatsu Shohei , Tsugawa Daisuke , Ajiki Tetsuo , Toyama Hirochika , Fukumoto Takumi
Published: May 2022

Purpose: Posthepatectomy liver failure (PHLF) is a major complication of hepatectomy. Although the extent of liver resection and fibrosis stages were previously identified as predictors of the development of PHLF, fibrosis stages were diagnosed using samples from resected livers. We evaluated the association between preoperative/intraoperative liver biopsies and final fibrosis stages.Methods: We included 272 patients who underwent an initial hepatectomy at our facility between January 2014 and December 2018.Results: PHLF occurred in 70 patients (25.7%) and decreased their overall survival (p = 0.0001). Preoperative/intraoperative liver biopsies showed a significant correlation with final fibrosis stages (p < 0.0001). The underestimation rates of preoperative and intraoperative F0/F1/F2 were 16.9% and 28.2%, respectively. Among the preoperative factors, 99mTc-GSA scintigraphy LHL < 0.91 was significantly associated with the resected liver fibrosis stages (hazard ratio [HR], 2.38; 95% confidence interval [CI]: 1.37–4.21; p = 0.0022). The underestimation rates of preoperative F0/F1/F2 with 99mTc-GSA scintigraphy LHL > 0.91 and <0.91 were 14.3% and 23.5%, respectively. None of the patients had underestimated final fibrosis stages based on intraoperative biopsies. The intraoperative fibrosis stages perfectly matched with final fibrosis stages in 86.4% of the cases, but the final fibrosis stages were overestimated in 13.6%.Conclusions: The fibrosis stages of the resected livers were associated with preoperative and intraoperative liver biopsies. Successful hepatectomies could be performed in accordance with findings from preoperative liver biopsies, 99mTc-GSA scintigraphy, and intraoperative liver biopsies without the incidence of PHLF.
Genome-based reclassification of Anoxybacillus karvacharensis Panosyan et al. as a later heterotypic synonym of Anoxybacillus kestanbolensis Dulger et al. 2004
Authors: BEKTAS Kadriye INAN , GULER Halil İbrahim , CANAKCI Sabriye , BELDUZ Ali Osman
Published: May 2022

In the present study, we attempted to clarify the relationship between Anoxybacillus karvacharensis K1T and Anoxybacillus kestanbolensis NCIMB13971T by using whole-genome phylogenetic analysis. The genome sequence of A.kestanbolensis NCIMB13971T was not available in any database, so it was sequenced in this study. The 16S rRNA gene sequence obtained from the genome of A.kestanbolensis NCIMB13971T had 99.93% similarity with A.karvacharensis K1T. Also, A.karvacharensis K1T and A.kestanbolensis NCIMB 13971T formed a robust branch different from other type strains of Anoxybacillus in the phylogenetic trees based on whole-genome sequences and 16S rRNA gene sequences. The average nucleotide identity (ANI), average amino acid identity (AAI) and digital DNA–DNA hybridization (DDH) values between A.karvacharensis K1T and A.kestanbolensis NCIMB13971T were greater than the threshold values for species demarcation. The present results indicate that both strains were considered to belong to the same species and A. karvacharensis K1T is later heterotypic synonym of A.kestanbolensis NCIMB13971T.
Grounded Theory-Based Model of Digital Communication’s Influence on Handicraft Intangible Cultural Heritage
Authors: li jia , Kim KieSu
Published: May 2022

The digital environment has altered the means of social interaction and information transmission, creating new media and models of cultural communication. Despite extensive investigations of the effect of digital communication on handicraft intangible cultural heritage (ICH), research on the relationship between factors influencing digital communication of handicraft ICH is relatively scarce. In this study, therefore, we obtained data related to influencing factors of digital handicraft ICH communication through in-depth interviews and text analysis. Then, using grounded theory, five core factors were found to have significant effects on the digital communication of handicraft ICH: digital communication awareness, initiative of cultural communication, adaptability of digital technology, audience acceptance and cognition, and uncontrollable factors. Furthermore, by analyzing the relationships among the five independent variables, a theoretical model of “consciousness–behavior–attitude” was constructed. Finally, the action mechanism of the theoretical model was identified and tested, and the action modes of each influencing factor were found to be inconsistent. Antecedent factors were directly proportional to consciousness–behavior, situational factors were inversely proportional to consciousness–behavior, and regulatory factors were inversely proportional to behavior–attitude. In addition, situational factors and regulatory factors had a positive impact on antecedent factors.
Effect of mesoscale eddies on the transport of low-salinity water from the Bay of Bengal into the Arabian Sea during winter
Authors: Zhu Jiechao , Zhang Yuhong , Cheng Xuhua , Wang Xiangpeng , Sun Qiwei , Du Yan
Published: May 2022

Significant contrast in sea surface salinity (SSS) emerges between the Arabian Sea (AS) and Bay of Bengal (BoB) caused by distinct air-sea freshwater flux and runoff inputs. The monsoon-induced inter-basin water exchange plays an important role in regional salinity balance and atmosphere-ocean feedback in the North Indian Ocean. The satellite SSS dataset reveals that significant intraseasonal variabilities of SSS occur in the south of India with stronger amplitude in winter than in summer. A case study in the late fall and earlier winter of 2016 shows that the Northeast Monsoon Current (NMC) and an eddy pair developed in the south of India plays a vital role in the intraseasonal variabilities of SSS there. In November, the East India Coasta Current (EICC) transports the low-salinity water southward to the east side of Sri Lanka. Meanwhile, a cyclonic eddy develops and propagates westward in the south of the NMC. Both NMC and the cyclonic eddy advects the low-salinity water westward to the south of India. Then, an anticyclonic eddy generates in the north of the NMC, forming an eddy pair with the cyclonic eddy. This eddy pair develops and propagates westward in the south of India for more than one and a half months, transporting low-salinity water westward. The perturbation of eddies and SSS gradient leads to the significant intraseasonal variability of SSS there.
Machine Learning-based Calibration of the GOCE Satellite Platform Magnetometers
Authors: Styp-Rekowski Kevin , Michaelis Ingo , Stolle Claudia , Baerenzung Julien , Korte Monika , Kao Odej
Published: May 2022

Additional datasets from space-based observations of the Earth's magnetic field are of high value to space physics and geomagnetism. The use of platform magnetometers from non-dedicated satellites has recently successfully provided additional spatial and temporal coverage of the magnetic field. The Gravity and steady-state Ocean Circulation Explorer (GOCE) mission was launched in March 2009 and ended in November 2013 with the purpose of measuring the Earth's gravity field. It also carried three platform magnetometers onboard. Careful calibration of the platform magnetometers can remove artificial disturbances caused by other satellite payload systems, improving the quality of the measurements. In this work, a Machine Learning-based approach is presented that uses neural networks to achieve a calibration that can incorporate a variety of collected information about the satellite system. The evaluation has shown that the approach is able to significantly reduce the calibration residual with a mean absolute residual of about 6.47nT for low-and mid-latitudes. In addition, the calibrated platform magnetometer data can be used for reconstructing the lithospheric field, due to the low altitude of the mission, and also observing other magnetic phenomena such as geomagnetic storms. Furthermore, the inclusion of the calibrated platform magnetometer data also allows improvement of geomagnetic field models. The calibrated dataset is published alongside this work.
Detection of Sebaceous Gland Hyperplasia with Dermoscopy and Reflectance Confocal Microscopy
Authors: Rao Lang , Lin Er-Yi , Wang Weng-Ju , Huang Xiao-wen
Published: May 2022

Sebaceous gland hyperplasia (SGH) is a benign cutaneous proliferation of the sebaceous glands that occurs in approximately 1% of the healthy population, mainly males. Our aim was to describe dermoscopy and reflectance confocal microscopy features of sebaceous gland hyperplasia. Thirty-one patients with sebaceous gland hyperplasia diagnosed according to the clinical and histopathological standards were examined using dermoscopy and reflectance confocal microscopy (RCM) from March 2018 to January 2022. Dermoscopically, lesions revealed yellowish-red background and faintyellow background in 25 cases (80.65%) and 6 cases (19.35%) respectively. White-yellowish lobulated structures in the center of the lesion were presented in 31 cases (100%) and umbilications in 19 patients (61.29%). Crown vessels in the peripheral of the lesions were observed in 11 cases (35.48%) while irregular linear vessels on the surface of the lesions in 18 cases (58.06%). Under the reflectance confocal microscopy, all lesions presented a honeycombed pattern in the epidermis and typical morulae-shaped sebaceous lobules in dermis. Dilated follicular infundibulum was observed in 15cases (48.39%) and dilated vessels in 26 cases (83.87%). In conclusion, dermoscopy and RCM enable us to describe the imaging features of SGH. Combing the two useful tools together provides a non-invasive basis for the accuracy of clinical diagnosis.
Attention Vision Transformers for Human Fall Detection
Authors: Bakshi Satyake
Published: May 2022

In recent years, Attention transformers have proven to be instrumental in Natural Language Processing (NLP) based tasks like sentence classification, and language translation. However, their application has been recently extended to large-scale object recognition tasks. In this work, Vision Transformer with attention has been investigated for the detection of human falls and ADLs (Activities of Daily Living) from time series-based signals. The Vision Transformer model has been trained and validated using the accelerometer signals of waist-worn Inertial Measurement Unit (IMU) sensors obtained from the IMU Falls dataset. The model is also trained and validated on the popularly used SiSFall dataset. The model is also investigated by independently training on 3 different cases of patch size and attention heads. It is observed that a larger patch size has resulted in significant performance deterioration. Additionally, smaller patch size took longer to train and was computationally expensive. The model performed (best-case) with an Accuracy (%) of 99.9 ± 0.1 and a True Positive Rate (%) of 99.9 ± 0.1 on the SFU-IMU dataset and with an Accuracy (%) of 99.8 ± 0.25 and a True Positive Rate (%) of 99.87 ± 0.3 on the SISFALL dataset. Overall, the results show that Transformers are highly robust in the detection of human falls and non-falls/ADL subject to the appropriate patch size.
Unrelated umbilical cord blood can improve the prognosis of haploidentical hematopoietic stem cell transplantation
Authors: Yang Ying , Zhang Ming , Li Mengqi , Li Yingchun , Yang Wei , Liu Zhuogang , Wang Hongtao
Published: May 2022

Background: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is widely used as a curative treatment strategy for most types of hematological diseases. However, strategies for enhancing the graft versus leukemia (GVL) effect without aggravating the graft versus host disease (GVHD) effect are still being pursued.Methods: A retrospective cohort study was performed to compare the outcomes between combined unrelated umbilical cord blood (UCB-haplo HSCT) and haplo HSCT. Results: The results showed that neither aGVHD nor cGVHD was increased in the UCB-haplo HSCT group, and the engraftment and infection rates were similar between the two groups. However, overall survival (OS) and progression-free survival (PFS) were significantly improved, while transplantation-related mortality (TRM) and relapse were significantly decreased in the UCB-haplo HSCT group by both univariate and multivariate analyses. Conclusion: Our results indicated that the addition of a UCB unit could improve the prognosis of haplo-HSCT and enhance the GVL effect without increasing the incidence of GVHD. Trial registration: The cohort study was retrospectively registered at https://www.chictr.org.cn as ChiCTR2100046681.
Determinants of Indonesian banking profitability: Before and during the COVID-19 pandemic analysis
Authors: Rohman Abdul , Nurkhin Ahmad , Mukhibad Hasan , Kusumantoro  , Wiradendi Wolor Christian
Published: May 2022

The purpose of this paper is to substantiate the determinants of Indonesian banking profitability before and during the COVID-19 pandemic. Return on assets (ROA), return on equity (ROE), and net interest margin (NIM) were used to measure banking profitability. The research population is 43 banks listed on the Indonesia Stock Exchange in 2020. Purposive sampling has been used to determine the research sample. The criteria are banks issued annual reports during the observation period (2019–2020). The data collection method used is documentation. Data analysis techniques used are descriptive analysis methods and multiple regression analysis. The results of the study indicate that banks experienced a decrease in profitability during the pandemic compared to before the pandemic. ROA before the pandemic was 0.82 and dropped to 0.62 during the pandemic; ROE from 1.76 to 1.32; and NIM became 4.79 from 4.91. Other results show that only Capital Adequacy Ratio CAR and Non-performing Loans (NPL) can determine bank profitability (ROA and ROE) significantly, both before and during the pandemic (the coefficient is –0.112 and –4.856 for CAR; –0.977 and –0.913 for NPL). CAR and NPL influence profitability negatively. Meanwhile, size and liquidity are not able to significantly influence profitability of Indonesian banking (ROA, ROE, and NIM). Bank management that can control NPL well will have a significant impact on profitability.
Acknowledgment We thank to Faculty of Economics and Business Universitas Diponegoro for the funding of research and publication.
Attribution of runoff variation to climate and human-driven changes in the transition zone between the Qinling Mountains and the Loess Plateau under vegetation greening
Authors: Wu Yanrui , Zhang Hongbo , Lan Tian , Wei Xingchen , Shao Shuting , Zhang Jingru , Ding Hao
Published: May 2022

The need for water safety management has increased in the transition zone between the Qinling Mountains and the Loess Plateau, China due to streamflow decline over the past 30 years. Vegetation greening, largely due to the result of the ‘Grain for Green’ program implemented in the Loess Plateau, is affecting regional streamflow together with climate change and direct human impacts. There is thus an urgent need to evaluate the relative importance of causes of streamflow variation in this region. A Hydrological Model of L′École de Technologie Supérieure (HMETS)-based segment identification analysis framework was presented to quantify the impacts of climate and human-driven changes on runoff under regional vegetation greening. Results showed that climate change and human interference were alternately dominant in the hydrological cycle from 1976 to 2015. Climate change played a major role in affecting runoff variation before 2000, and then human interference dominated. It is worth noting that temperature increases resulted in runoff reduction and induced more changes in streamflow when precipitation was high. Vegetation greening contributed highly to streamflow attenuation, and its impact on runoff variation was more significant after 2007. Generally, understanding the effects of temperature increases and vegetation greening on streamflow is important for the development of appropriate adaptation strategies for the planning and management of regional water resources.
Novel water treatment system in a low-resource community
Authors: Nogueira R. C. , Nigro M. , Veuthey J. , Thior M. D. F , Amour C. O. D. , Voillat J.
Published: May 2022

This paper evaluates the performance of a low-cost technology in rural Benin (West Africa) that locally produces chlorine (sodium hypochlorite) and then injects it into the community water tanks. Thirty-one water tanks were selected in cooperation with local authorities to receive electro-chlorinator devices (WATA™). Water samples were tested at two points: before chlorination and at the most distant terminal after chlorination. Residual chlorine control tests and microbiology control tests were performed. Water samples that tested positive for the presence of microorganisms were analyzed at a laboratory when possible. The water provided to the community was not always chlorinated, and over half of the tanks lacked access to chlorine powder. Among the sites using the technology, 30% (9/31) of them had structural problems that prevented the existing system from performing adequately. Furthermore, 60% of the water samples collected before chlorination were positive for microbiological contamination. All samples collected from systems where proper chlorination was taking place tested negative for microbiological contamination. However, the water from six tanks presenting structural problems continued to be distributed to the population despite contamination. The average residual chlorine level analyzed at the most distant terminal fountain was 0.29±0.2 mg/L, which is within the country's reference level 0.1–0.8 mg/L. The installation of water-chlorinator devices (WATA™) produces water without microbiological contamination and with chlorine levels within the WHO's recommended values. However, the success of the technology depends on the pre-existing structure of the water tank.
A negatívnyomás-terápia alkalmazása : 5 éves áttekintés
Authors: Jagri Ádám , Körmöndi Sándor , Török László , Varga Endre
Published: May 2022

A negatívnyomás-terápia a krónikus sebellátás gold standardjává vált a traumatológiai gyakorlatban is. A szerzők retrospektív klinikai vizsgálatukban kívánták megfigyelni a negatívnyomás-terápia alkalmazásának előnyeit és korlátait gyakorlatukban. Eredményeik alapján azt tapasztalták, hogy a nemzetközi trendeknek megfelelően egyre nagyobb számban, szélesebb indikációkkal alkalmazható a kezelés a traumatológiában is. Emellett megfigyelték, hogy gyakori mechanikus sebtisztítás mellett – amely a nemzetközi tapasztalatokkal ellentétben a gyakorlatukban nem szorult háttérbe – elérhető a gyógyulás még súlyos, szövődményes esetekben is. Ennek ellenére a kezelés szövődményrátája nem különbözött a hagyományos kötszerekétől. A szerzőknek azonban nem sikerült igazolniuk, hogy a terápia alkalmazása csökkentené a kórházi ápolás, valamint az antibiotikus kezelés idejét. Feltételezik, hogy ennek hátterében a vizsgálat retrospektív módja, a csoportba sorolás egyenlőtlenségei állhatnak. Így a felvetések igazolására további vizsgálatok lehetnek szükségesek.
Patella instabilitás kezelésének rövidtávú eredményei medialis patellofemoralis szalagpótlással
Authors: Horváth Ádám , Tavaszi Zsolt , Novográdecz Gergely , Mintál Tibor
Published: May 2022

A térdkalács instabilitása viszonylag gyakran előforduló kórkép, amely általában már gyermekkorban, illetve fiatal felnőttkorban diagnosztizálásra kerül. A térdkalács megfelelő helyzetéért csontos és lágyrész képletek egyaránt felelősek. Az elsődleges medialis stabilizátor a medialis patellofemoralis szalag. Az instabilitás kezelésére operatív ellátás esetén számos technika ismert, lágyrész valamint csontos műtétek a térd extensor apparátus proximalis és distalis régiójában. A szerzők megvizsgálták a patella instabilitás miatt 2016. január 1. – 2019. december 31. között intézetükben a medialis patellofemoralis szalagpótlásban részesült betegeket. 12 esetben történt szalagpótlás saját Hamstring inakkal. A műtétet artroszkóppal asszisztálva végezték, amely során lateralis retinaculum behasítás is történt. A felmérések retrospektíven, a beavatkozásokat követően átlag 9 hónappal történtek. Az elvégzett fizikális, radiológiai vizsgálatok, valamint a szubjektív és objektív tesztek (IKDC, Tegner, Lysholm) alapján a betegeknél kiváló és jó eredményeket mutattak ki. Ismételt ficam egy esetben sem volt. Következtetésként elmondható, hogy a medialis patellofemoralis szalagpótlás megfelelő módszer lehet a patella instabilitás kezelésére.
Akut osteomyelitis és szeptikus arthritis gyermekkorban
Authors: Ráskai Csaba , Kassai Tamás , Fényes László
Published: May 2022

A gyermekkori akut osteomyelitis és szeptikus arthritis súlyos, olykor ma is tragikus kimenetelű betegség. Diagnózisa – különösen csecsemők, kisgyermekek esetén – sokszor komoly nehézségekbe ütközik, az időben megkezdett megfelelő terápia pedig rendkívül fontos a szövődmények megelőzése szempontjából. A közlemény a gyakorló orvos számára jól használható, tömör összefoglalót kíván adni a gyermekkori csont-ízületi fertőzések diagnózisáról és kezeléséről. Több nemzetközi tankönyv és publikáció felhasználásával készült, tartalmazza a legfrissebb európai és amerikai ajánlásokat. Olyan egyszerű diagnosztikai és terápiás algoritmus bemutatására törekszik, amely a mindennapi munka során segíti a gyermekgyógyászt, az ortopéd-traumatológust, vagy akár protokollként alkalmazható sürgősségi osztályokon.