bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Acupuncture and Acupressure Therapy Against a Decline in The Level of Pain in Lower Limb Pain in Dukuh Duwetan
Authors: Sholihah Imrok Atus
Published: January 2022

Background: The Lower Limb is the body prone to pain and injuries due to prop up the overall weight. Acupuncture is an eastern medicine with stabbing needles on the specific surface area of the body that can cause analgesic effects. Acupressure massage therapy development emphasizes acupuncture points that increase the saturation of oxygen and cause muscle relaxation effects. Our study aimed to identify the influence of acupuncture and acupressure therapy against a decline in the lower limb pain sufferers' pain level.

Subject and method: The study was conducted in February-March In Dukuh Duwetan, Village Jumantono, district Ngunut, Karanganyar Regency. The sample of the research taken is 30 farmers, both men, and women, aged 30-50 years have lower limb pain complained during and after work. This research is a pre-experimental design with One Group pretest-posttest with a 30 community Dukuh Duwetan meets the criteria of inclusion. The data collected is the primary data with the recording and assessment of the results of the action. Statistical tests using univariate analysis and bivariate analysis using Wilcoxon.

Result: There is a decreasing scale of pain in lower limb pain sufferers community Dukuh Duwetan with the value of the Wilcoxon test p = 0.00 < 0.05.

Conclusion: The presence of acupuncture and acupressure therapy were influence against downturn lower limb pain.

 
CODE CHOICE USED IN YOUTUBE CONTENT “NEBENG BOY”
Authors: Angelia Caecilia Ivana
Published: January 2022

Nebeng Boy is one of the most popular YouTube content created by Indonesian YouTuber and an ex-Video Jockey from MTV, Boy William. The participants in this YouTube content are divided into two; the Host and the Guests. This research aims to find out the code choices chosen by the participants of YouTube content “Nebeng Boy” and the reasons why the participants choose the different codes.

This research was a case study of sociolinguistics which employed a descriptive qualitative method. In collecting the data, the researcher has done a few techniques namely taking notes from observing the conversation, transcribing the dialogues between participants, and classifying the data. The researcher used total sampling technique and took the whole part of dialogue from six videos of “Nebeng Boy”.

The results of this research show that the code choices employed by the participants of Nebeng Boy are informal variety from Bahasa Indonesia and English which resembles of high social class or high social status. Each participant has different way in using the codes and also has different reason behind it. The Host of the program uses informal code choices to show solidarity, express emotions, show intimacy, changing topics, and including another person to the conversation. Meanwhile, the factors that the guests use the code choices are the background of the person, the profession, function of the conversation, topics, the situation of conversation, and to include another person.
KAUSALITAS DALAM NOVEL LELAKI HARIMAU KARYA EKA KURNIAWAN
Authors: Ramadhan Ibnu Yustiya
Published: January 2022

In Eka Kurniawan’s novel, Lelaki Harimau, incoherent story telling is one of its most visible characteristeristic. Incohorent story telling is used by Eka kurniawan not only to pique the reader interest but also to emphasise cause and effect in every action that characters do in the novel. With a theory offered by Genette, this study tries to explain the order of event in Lelaki Harimau to show the causality that Eka Kruniawan use as the core theme in his novel. This study also tries to show how structural theories can be used as a foundation to interpret novel. From the explanation of causality in Lelaki Harimau novel, it is found that violence only begets violence.
Neuroeducação e dificuldades de leitura e escrita: análise à luz da Neurolinguística Discursiva
Authors: Moutinho Isabella de Cássia Netto , Coudry Maria Irma Hadler
Published: January 2022

Um dos objetos de análise da Neurolinguística Discursiva (ND) é o aumento de cursos que relacionam os estudos da cognição, a psicologia e a neurologia – as chamadas neurociências – com a educação. O objetivo desses cursos, em geral, é ajudar o professor a compreender processos biológicos envolvidos na aprendizagem e o funcionamento cerebral, o que, em tese, ajudaria a compreender as dificuldades dos alunos e repensar as práticas pedagógicas. Neste trabalho, analisamos o recente avanço das chamadas Neurociências ou a Neuroeducação sobre os cursos de formação de professores e sua abordagem das dificuldades de aprendizagem, sobretudo da Dislexia. À luz da ND, analisamos um artigo representativo do ponto de vista que a Neurociência divulga sobre a Dislexia e propomos um contradiscurso para esta perspectiva.
Investigating telecollaborative genres: analysis of teletandem oral sessions communicative purpose through learners’ diaries
Authors: Rampazzo Laura
Published: January 2022

This paper aims to investigate the communicative purpose of a telecollaborative genre, namely the initial teletandem oral session (iTOS), the first virtual encounter between learners who participate in the Teletandem Brasil project. Although telecollaborative genres are still underexplored, studies have been advancing in observing the development of a community, and in identifying the patterns of action that are effective. Through the analysis of 17 learners’ diaries, available at Multimodal Teletandem Corpus, the present study examines students’ stance on the communicative purpose of the genre. Results suggest that learners recognize the purpose of iTOS to be to get to know their partners and find common ground, and indicate that both learners and researchers have similar views on what the communicative purpose of the genre iTOS is.
Análise de Marcas de dois governos federais pós-impeachment
Authors: Professor Juciano Rocha , Saparas Marcelo
Published: January 2022

Este trabalho corresponde a um recorte da pesquisa de Mestrado de um dos autores, a respeito da análise de Marcas de Governo – construções imagéticas produzidas pela Secretaria Especial de Comunicação Social (SECOM) para identificar visualmente o mandato de um presidente da República. Os dados de análise são duas Marcas de Governo, gestão Itamar Franco e gestão Michel Temer, escolhidas por serem ambas de mandatos pós-impeachment. O objetivo deste trabalho é analisar, conforme a Gramática do Design Visual (KRESS; van LEEUWEN, 2006) e teoria da Metáfora e Metonímia Conceptuais (LAKOFF; JOHNSON, 2002; SAPARAS; IKEDA, 2017; FENG, 2017), a relação dessas Marcas com as Marcas dos governos que os antecedem, bem como as metáforas e metonímias que as compõem. Deste modo, foi possível perceber que, embora sob formas diferentes, ambas as Marcas foram construídas de maneira a evitar a associação com as construções dos governos anteriores, alvo de impeachment. Foi observada, também, a metonímia do tipo PARTE PELO TODO tanto na Marca de Franco quanto de Temer, fazendo remissão, nos dois casos, à Bandeira do Brasil.
Low-Cost Sensors Provide Insight into Temporal Variation in Fugitive Methane Gas Concentrations Around an Energy Well
Authors: Fleming Neil A. , Morais Tiago A. , Cathryn Ryan M.
Published: January 2022

Effective measurement of the presence and rate of methane gas migration (GM) outside the casing of energy wells is important for managing social and environmental impacts and financial liabilities in the upstream petroleum industry. Practitioners typically assess GM by above-background methane gas concentrations in-soil or at-grade; however, factors influencing the potential variation in these measurements are not well represented in industry-recommended best practices.

Inexpensive chemoresistive sensors were used to record a 1-minute frequency methane gas concentration time series over 19 days. Time series were recorded at three soil depths (0, 5, and 30 cm) at two locations <30 mcm radially from a petroleum well with known GM, in addition to two “control” locations. Observed concentration variations ranged over several orders of magnitude at all depths, with generally lower concentrations and more variation observed at shallower depths. Varying concentrations were correlated to meteorological factors, primarily including wind speed and shallow groundwater table elevation. The gas concentration patterns were affected by a 3.5-mm rainfall event, suggesting soil moisture changes affected preferential GM pathways. Results indicate potential variability in repeated snapshot GM test results. Although, currently recommended GM detection methods would have effectively identified the presence/absence of GM, they would not have quantified the order of magnitude changes in concentration. GM detection success at this site was increased with measurement at more than one location spatially within 30 cm of the well casing, lower concentration detection limits, and greater measurement depth. These findings indicate that meteorological factors should be considered when conducting GM surveys (particularly for improving at-grade test reliability). The low-cost approach for long-term concentration measurement facilitates insight into variable gas concentrations and may be advantageous in comparison to snapshot measurements in some circumstances.
The essence of male scent promotes female puberty and estrus
Authors: Holy Timothy , Fu Xiaoyan , Lee Donghoon , Evans Bradley
Published: January 2022

Pheromones are chemical signals that trigger a response in another member of the same species. In mice, it has been shown that exposure of females to male pheromones leads to puberty advance and estrus induction. In particular, these effects can be triggered by conspecific male urine, suggesting that they are related to the chemical composition of this stimulus. Although these phenomena were among the earliest known examples of pheromonal actions, the identities of these chemical signals remain mysterious. Here we identified two small molecules in male urine, termed Calin319 and Calin381 that accounted for much of the vomeronasal neuronal response to male urine and were sufficient and necessary to advance juvenile female puberty and induce female estrus. Besides acting as a primer pheromone, a blend of these two male compounds also acts as a releaser pheromone that resulted in increased investigatory behavior by female mice. These findings demonstrate that Calin319 and Calin381 are crucial male pheromones that regulate female reproductive behavior in mice. This study resolves the long-standing mystery of the molecular code of male urinary chemicals that control female gonadal function.
Short-Term Field Research on Air Pollution within the Boundaries of the Large City in the Baltic Region
Authors: Chlebnikovas Aleksandras , Paliulis Dainius , Bradulienė Jolita , Januševičius Tomas
Published: January 2022

Air quality in urban and suburban areas is strongly affected by the level of local urbanization, climatic conditions and industrial activity. Monitoring the main air pollutants such as nitrоgеn оxidеs, cаrbоn mоnоxide and particulatе mаttеr may help control thе most polluted areas of the site and take measures to reduce pollution. Uncontrolled emissions from other chemical pollutants, including volatile organic compounds and odorous contamination sources like ammonia may cause both a chronic human disease and damage to flora and fauna. The conducted field research is aimed at determining air pollution within the areas of the large city (residential territory, recreation territory and the areas close to intense transport streets) polluted with the gaseous pollutants of varying nature (CO, NO2, ozone, sulfur dioxide, VOC and NH3) as well as particulate matter in different seasons of the year. Studies on Vilnius district air quality were carried out in 17 urban locations (points) and based on two-phase measurements. The first phase was initiated in 2016–2017 and the second one took place in 2019–2020.
G-CSF-mobilized Peripheral Blood Mononuclear Cells Combined with Platelet-rich Plasma Restored the Ovarian Function of aged rats via angiogenesis and glycolysis modulation
Authors: Yuan Lifang , Hang Weiyu , Bi Yin , Chen Saiqiong , Wang Xi , Li Ting , Wei Peiru , Du Jiebing , Zhao Ling , Liu Bo , Yang Yihua
Published: January 2022

Background: The ovarian function restoration of premature ovarian insufficiency (POI) patients is one of the most challenging problems in the reproduction field, as no evidence-based efficient therapy exists. Regenerative medicine with peripheral blood mononuclear cells (PBMCs) transplantation sheds light on this issue. However, the efficiency and safety of PBMCs treatment in patients with natural ovarian aging (NOA) remain unclear.Methods: To investigate the effect of PBMCs alone or combined with PRP on NOA functional recovery, we used 13-month-old female Sprague–Dawley (SD) rats as an NOA model. Seventy-two NOA rats were randomly divided into three groups: the NOA control group, PBMCs group, and PBMCs combined with platelet-rich plasma (PRP) group. PBMCs and PRP were transplanted by intraovarian injection. The effects of ovarian function and fertility ability were measured and compared among different groups after transplantation.Results: Intraovarian transplantation of PBMCs alone or in combination with PRP resulted in restoration of the normal estrus cycle, consistent with recovery of serum sex hormone levels, increased follicle numbers at all stages, and restoration of fertility by facilitating pregnancy and live birth. Moreover, when combined with PRP injection, these effects were more significant. The male-specific SRY gene was detected in the ovary at all four time points, which suggested that PBMCs continuously survived and functioned in NOA rats. In addition, after PBMCs treatment, the expression of the angiogenesis-related marker VEGF and glycolysis-related molecules lactate dehydrogenase A (LDH-A) and sirtuin 1 (SIRT1) in NOA-overexpressing cells was upregulated, which indicated that these effects were associated with angiogenesis and glycolysis.Conclusions: PBMCs transplantation can restore the ovarian functions and fertility of NOA rats by increasing ovarian vascularization, folliculogenesis and glycolysis, and PRP could enhance the efficiency. However, more studies are required to evaluate the feasibility, safety, and efficacy of these novel fertility-preserving methods.
The Prevalence of Cardiovascular Risk Factors in Patients with and Without Metabolic Syndrome in Diabetes Mellitus: A Study Based on Rafsanjan Cohort Study
Authors: Kamiab Zahra , Abbasifard Mitra , Nadimi Ali Esmaeili , Alinejad Hasan , Bazmandegan Gholamreza
Published: January 2022

Background
Cardiovascular disease (CVD) is the leading causes of death and disability in diabetes. This study aimed to determine the prevalence of cardiovascular risk factors in people with and without metabolic syndrome (MtS) in diabetes mellitus (DM).
Methods
This cross-sectional study was part of Rafsanjan Cohort Study (RCS).as part of the comprehensive PERSIAN (Prospective Epidemiological Research Studies in IrAN) on adults with and without MtS in DM. CVD risk factors, including gender, age, blood pressure, dyslipidemia, smoking, alcohol consumption, fasting blood sugar, creatinine, blood urea, waist circumference, body mass index, family history, physical inactivity, fruit and vegetable consumption were collected in the PERSIAN Cohort Questionnaire. The data were analyzed by SPSS software version 22.
Results
The prevalence of MtS in 1933 participants was estimated to be 80% (95% confidence interval 81.8% -78.1%). In the logistic regression model, smoking, alcohol consumption, triglyceride to HDL (High Density Lipoprotein) ratio, abdominal obesity, and hypertension were identified as the factors associated with MtS.
Conclusions
Our results show that Based on our study, the prevalence of cardiovascular risk factors in DM was high. Reducing smoking and alcohol consumption and controlling hypertension, hyperlipidemia, and overweight are the suggested solutions in this field.
Reactive strength index during single-leg vertical continuous jumps after anterior cruciate ligament reconstruction: cross-sectional study
Authors: Hirohata Kenji , Aizawa Junya , Ohmi Takehiro , Ohji Shunsuke , Mitomo Sho , Ohara Toshiyuki , Koga Hideyuki , Yagishita Kazuyoshi , Jinno Tetsuya , Okawa Atsushi
Published: January 2022

Background

The association of the reactive strength index (RSI) during single-leg vertical continuous jumps (SVCJs) with single-leg hop tests in athletes after anterior cruciate ligament reconstruction (ACLR) is unclear. Thus, this study aimed to confirm the measurement properties of the RSI during SVCJs in athletes with ACLR at the phase of determining the timing of their return to sport.
Methods

RSI during SVCJs and single-leg hop (single, triple, and crossover) tests were measured for post-ACLR and healthy athletes. The limb symmetry index (LSI) was calculated using the measurements of each parameter. For each test, patients were divided into two subgroups according to their LSI score (≥90%, satisfactory; <90%, unsatisfactory). Fisher’s exact test was used to examine the association of single-leg hop tests with RSI during the SVCJs.
Results

A total of 21 post-ACLR and 17 healthy athletes completed all the tests. RSI during SVCJs were significantly lower on the involved limb than on the uninvolved limb in post-ACLR athletes (P < 0.001). The LSI of RSI during SVCJs of post-ACLR athletes were significantly lower than that of the healthy athletes (P < 0.01). Among the post-ACLR athletes, <30% of those with LSIs >90% in the single-leg hop tests had an LSI >90% of the RSI during SVCJs.
Conclusions

RSI during SVCJs of post-ACLR athletes was significantly lower on the involved limb than on the uninvolved limb, and the asymmetry was more remarkable in the SVCJs than in the single-leg hop tests.
Analysis of the Risk Factors of Soft Tissue Bleeding Phenomenon in Covid-19 Patients: the Point of View After Two Years of the Pandemic.
Authors: Faiella Eliodoro , Castiello Gennaro , Santucci Domiziana , Altomare Carlo , Pacella Giuseppina , Bernetti Caterina , Ferrari Ugo , Villamu Moises Muley , Incalzi Raffaele Antonelli , Zobel Bruno Beomonte , Grasso Rosario Francesco
Published: January 2022

Background: to analyze the relationship between patient characteristics, including anagraphic, laboratoristic data and amount of adipose tissue measured in Computed Tomography (CT)-scans in COVID-19 patients, and incidence of soft-tissue bleeding requiring medical and/or interventional radiology management. A total of 132 patients hospitalized for COVID-19 pathology from October 2020 to May 2021, were included in the study, considering two groups: a bleeding group, 70 cases of soft-tissue bleeding occurred during hospitalization, and a control group, 62 hospitalized COVID-19 patients without bleeding events. In the bleeding group, two subgroups were considered: an embolization group including soft tissue bleeding cases requiring interventional radiology TAE (Transarterial Embolization) (16/70; 22.9%) and a non-embolization group, clinically managed without TAE (54/70; 77.1%). Demographics and clinical data, visceral adipose tissue (VAT), sub-cutaneous adipose tissue (SAT) areas measured on CT images and VAT/SAT ratio were compared between bleeding and control groups and between embolization and non-embolization subgroups. Results: Bleeding and control groups did not significantly differ for sex distribution, Covid-19, platelet count, SAT-area, VAT-area and VAT/SAT ratio. Embolization and non-embolization groups did not significantly differ for age, Covid-19, platelet count, SAT area, and VAT/SAT ratio. A statistically significant difference was observed between embolization and non-embolization groups for VAT area, with smaller values in embolization group (mean difference: 64.2 cm², 95% CI, 8.3 – 120.1; p<0.05). Conclusions: Soft-tissue bleeding in COVID-19 is more frequent and severe in patients with low amount of visceral adipose tissue, demonstrating that fat mass may have a containing function on bleeding, limiting its progression in surrounding structures. Other factors influence the risk of bleeding, such as age.
Identifying the functional pathways and potential genes associated with interferon signaling during human adenovirus type 7 (HAdV-7) by weighted gene co-expression network analysis
Authors: Yang Zhongying , Wei Jianhua , He Yu , Ren Luo , Chen Shiyi , Deng Yu , Zang Na , Liu Enmei
Published: January 2022

Background
Human adenovirus type 7 (HAdV-7) can cause severe pneumonia in children and severe complications. At present, however, the pathogenesis and genes involved remain largely unknown.
Methods
We collected HAdV-7 infected and mock-infected A549 cells at 24, 48, and 72 hours post-infection (hpi) for RNA sequencing (RNA-seq). And, we identified potential genes and functional pathways associated with HAdV-7 infection using weighted gene co-expression network analysis (WGCNA).
Results
Based on bioinformatics analysis, 12 co-expression modules were constructed by WGCNA, with the blue, tan, and brown modules significantly positively correlated with Ad-24 hpi, Ad-48 hpi, and Ad-72 hpi, respectively. Functional enrichment analysis indicated that the blue module was mainly enriched in DNA replication, cell cycle, and viral process; the tan module was largely enriched in metabolic pathways and regulation of superoxide radical removal; and the brown module was predominantly enriched in mitochondrial respiratory chains and regulation of cell death. Quantitative polymerase chain reaction (qPCR) was used to determine transcript abundance of some identified hub genes, and results were consistent with those from RNA-seq. Based on comprehensive analysis of hub genes and differentially expressed genes (DEGs) in the GSE68004 dataset, we identified SOCS3, OASL, ISG15, and IFIT1 as potential candidate genes for biomarkers or drug targeting in HAdV-7 infection. Further, we propose a multi-target inhibition of interferon signaling mechanism to explain the HAdV-7 associated with higher severity of clinical consequences.
Conclusions
We constructed a framework of co-expression gene modules from A549 cells infected with HAdV-7, thus providing a basis for identifying potential genes and pathways involved in adenovirus infection and for studying the pathogenesis of adenoviruses.
Critical Observations on the Dynamic Change in Caliber of Interarterial Segment of Anomalous Coronary Arteries on CT Angiogram in Patients with Chest Pain and Treadmill Test Findings - A Potential ‘Game-Changer’ Information in the Patient Management
Authors: Mahalingam Vijay , Gadabanahalli Karthik , Bhat Venkatraman
Published: January 2022

Aims and backgroundThe incidence of coronary artery anomalies is rare in the general population, anomalous origin of right coronary artery being the most common. These anomalies, particularly anomalous coronary arteries with an interarterial course (ACAIAC) are potentially dangerous. Due to their low incidence, meticulous clinical and imaging guidelines have not yet been defined in assessing such patients and guiding management. Methods and resultsCT coronary angiograms of patients who underwent the study for exclusion of coronary artery disease were reviewed. Patients with ACAIAC were recorded. The images were reviewed and reconstructed to measure the caliber and area of the narrowest interarterial segment of ACAIAC in systolic and diastolic phases using Philips Intellispace version 12.1 software.Percentage change in area (p value 0.093) and diameter (p value 0.108) of the interarterial segment in systolic and diastolic segments, was statistically significant between anomalous coronaries with high and low interarterial course. Percentage change in area and diameter between patients with positive and negative TMT findings was also statistically significant (p<0.001 in both cases). ConclusionSignificant positive correlation between change in vessel caliber in the interarterial course of coronary arteries during the cardiac cycle and TMT findings, suggests elevated risk of inducible ischemia in patients with significant vessel compression. Hence the change in vessel caliber can be used as a potential criterion for risk assessment and management of patients with ACAIAC.
A Sclerosing Stromal Tumour of the Ovary in a postmenopausal Female: A Rare Case Report
Authors: Saraf Pallavi , BHARTI JYOTSNA NARESH , Sharma Charu
Published: January 2022

Sclerosing stromal tumour (SST) is an extremely rare benign ovarian neoplasm, usually seen in young females. We report a case of a 55-year-old female who presented with pelvic pain and irregular bleeding. On imaging, she was suspected of have a borderline malignant tumour of the left ovary and benign teratoma of the right ovary. Postoperatively, diagnosis of SST of left ovary and mature cystic teratoma of right ovary was made after histopathological examination and immunohistochemistry. Our case is unique because SST is a rare entity, and its existence with teratoma has not been reported to date in the literature; and lastly, its occurrence in elderly females is also rarer.
Cost-efficient multiplex PCR-based metabarcoding with new comprehensive primer sets for monitoring plankton diversity dynamics
Authors: Zou Shanmei , Smith Lydia
Published: January 2022

Aim: Accurate and quick monitoring of plankton diversity dynamics is critical and urgent for aquatic environmental protection, especially for bloom management. Multiple genetic markers with efficient primers should be considered for accurate species detection by metabarcoding. Here we aim to provide cost-efficient multiplex PCR-based metabarcoding (CMPM) with new comprehensive primer sets for monitoring plankton diversity dynamics. The CMPM assay was tested in samples from Lake Tai.Location: Freshwater Lake Tai, ChinaMethods: A total of nine primer sets from 18S, 28S, 23S, 16S and rbcL was presented, including five newly designed ones 18S-v4-5, 28S, 16S-new, rbcL-Chlo and rbcL-Cry in this study. Three multiplex PCR-based system were developed for Next Generation Sequencing of all nine genetic markers. The assignment efficiency of new primer sets for plankton were detected. The taxonomic assignments of all genetic markers were compared in each of species, genus and family level. The single and multiplex PCR-based metabarcoding were compared. The assignments from multiple genetic markers and microscope observations were compared in the reference samples. The CMPM assay was tested in samples from Lake Tai. Results: The taxonomic assignments of all nine genetic markers differed from each other in each of species, genus, family and phylum level. The 28S identified a higher proportion of phytoplankton, zooplankton and fungi with high assignment performance in species level. The 16S-new marker not only obtained large cyanobacteria assignments, but also obtained other assignments from phytoplankton and bacteria. The new 18S-v4-5 was much variant to detect a broader range of zooplankton and phytoplankton. The two new primer sets of rbcL-Chlo and rbcL-Cry specifically assigned Chlorophyta and Cryptophyta successfully. The multiple genetic markers produced more plankton assignments than microscope observations. The plankton communities in Lake Tai showed pronounced seasonal dynamic by CMPM, which is consistent with the previous reports. Main conclusions: The 28S, 16S-new and 18S-v4-5 newlywed designed here could be as complementary universal genetic markers for identifying plankton. The rbcL-Chlo and rbcL-Cry could be as specific markers for identifying Chlorophyta and Cryptophyta respectively. The CMPM assay can provide precise identification and save cost for monitoring plankton diversity dynamics with comprehensive primer sets.
Fertilidad en yeguas y caracterización de la dinámica ovárica
Authors: Romero-Márquez Constantino , Pérez-Anzúrez Gustavo , Huerta-Bravo Maximino , López-Ordaz Rufino , Ruíz-Flores Agustín
Published: January 2022

La baja fertilidad es una de las mayores dificultades que enfrenta la reproducción equina. El diámetro folicular preovulatorio puede utilizarse como predictor del celo.
Métodos: Se estudió la evolución del diámetro folicular (DF) durante un ciclo estral en 43 yeguas, con 550 ± 34 kg PV, edad 6.00 ± 2.30 años y 4.42 ± 0.39 de condición corporal (CC), sin problemas reproductivos o sanitarios. Los celos se detectaron y los DF se midieron diariamente; las yeguas con DF > 38 mm se inseminaron, y la preñez se diagnosticó 16 d post inseminación. Las variables evaluadas fueron: duración del celo (Dcelo) y del ciclo estral (Dciclo); DF al día 21 (DF21), al inicio del celo (Dfcelo) y a la inseminación artificial (DFIA); diámetro del cuerpo lúteo (DCL), y tasa de preñez (TP16). Los efectos fijos incluidos en el modelo fueron: edad de la yegua, CC, Dcelo, Dciclo, número de folículos, tiempo que tardó en presentarse el celo después del día 21 (Celoh), Dfcelo, y DF21. Los análisis estadísticos se realizaron con los procedimientos MIXED y GLIMMIX de SAS.
Resultados: La edad (p £ 0.0221) y el Dcelo (p £ 0.036) fueron significativas para la mayoría de las variables de respuesta analizadas. Las yeguas de 9-11 años tuvieron los mayores Dciclo, DCL y DF. La covariable Dfcelo fue significativa (p £ 0.0056) para DCL y DF21; mientras que DF21 lo fue (p £ 0.0001) para Celoh, Dfcelo y DFIA. El crecimiento folicular mostró una tendencia cúbica, con una reducción en la tasa de crecimiento días previos a la ovulación.
Conclusión: La edad de la yegua, DF21 y Dfcelo, ayudan a predecir la presentación del celo. El conocimiento de la dinámica ovárica ayuda al apareamiento al tiempo correcto en yeguas.
Matrix Metalloproteinases; A Biomarker of Disease Activity and Prognosis
in Spondyloarthritis: A Narrative Review
Authors: Rahmouni Safa , Slouma Maroua , Bouzid Sirine , Dhahri Rim , Litaiem Noureddine , Gharsallah Imen , Metoui Leila , Louzir Bassem
Published: January 2022

Background:

Matrix metalloproteinases, as components of the proteolytic system, are
deemed to be implicated in the pathogenesis and progression of several rheumatic diseases. Their role
in spondyloarthritis has been investigated by several studies.

Objective:

This article aims to review and summarize the current knowledge related to metalloproteinases
in patients with spondyloarthritis.

Methods:

To examine the association between matrix metalloproteinases and spondyloarthritis, we
conducted a narrative review using a literature search in SCOPUS for English-language sources. The
search included studies published from the database inception to December 2020.

Results:

A total number of 74 articles were included. It was found that levels of matrix metalloproteinases
3 were higher in radiographic axial spondyloarthritis patients and seemed to play a role in the
progression of joint damage. The levels of matrix metalloproteinases 1, 2, and 9 were upregulated in
psoriatic arthritis patients compared to psoriasis and could identify psoriasis patients who would develop
rheumatic manifestations. The levels of matrix metalloproteinases correlated significantly with
disease activity in ankylosing spondylitis and decreased upon treatment with Tumor Necrosis Factor
inhibitors (TNFi).

Conclusion:

Excessive matrix metalloproteinases activity is associated with articular destruction.
Their levels can reflect disease activity, structural damage, and response to TNFi in patients with
spondyloarthritis. Nevertheless, further studies are needed to confirm these results.
Violence, Science, and Cotton in Colonial-Fascist Mozambique (1934-1974)
Authors: Guimarães Paulo
Published: January 2022

Since the 19th century, Portuguese authorities had made unsuccessful attempts to promote cotton production in Angola and Mozambique. Under colonial fascist rule, the cotton plantations expanded significantly to meet the demands of the Portuguese textile industry. Eventually, cotton became the major agricultural export in Mozambique. This text explores the causes for this success, focusing on the rapid growth of indigenous cotton fields in northern Mozambique. In our research, we analysed contemporary "grey" cotton scientific literature, labour legislation, administration reports, agronomical thesis and the extensive collection of anthropological and social history studies carried out since the 1970s. We demonstrate that fascism created a specific model for the exploitation of humans and nature. This model involved labour mobilization based on daily physical and psychological violence and the humiliation of the indigenous people, the promotion and advancement of colonial cotton science for the industrialization of nature, and the creation of new economic institutions and rules to promote neo-mercantilist policies.
Возможности моделирования из первых принципов электрон-фононной релаксации и транспортных свойств на примерах оксида кадмия и титаната стронция
Authors: Жуков В.П. , Чулков Е.В.
Published: January 2022

The calculations of the electron-phonon relaxation time, Seebeck coefficient and conductivity were performed for cadmium oxide with oxygen vacancies and strontium titanate doped with niobium using the first-principle methods based on the theory of electron density functional and its perturbations, Boltzmann theory and many-body theory of electron-phonon interaction. It is shown that the calculations of relaxation time based on the many-body theory lead to significantly more accurate results on transport characteristics than in the case of the standard approximation of a constant relaxation time. It is shown that interaction with defects has a significant effect on conductivity.
Reparación Directa y Conflicto Armado Interno. La Constitucionalización de la Responsabilidad Extracontractual del Estado
Authors: Roncancio-B. Andrés Felipe , Restrepo-M. Mariana , Hoyos-García José Fernando
Published: January 2022

Introducción: En materia de responsabilidad extracontractual del Estado, los procesos de reparación directa que se han derivado de hechos con ocasión al Conflicto Armado Interno, en adelante -CAI- han generado cambios en las categorías de protección que se han ido transformando especialmente desde que se reconoce la existencia del CAI. Objetivo: el principal objetivo de esta investigación está articulado a determinar cuáles son las condiciones que se han valorado por parte del Consejo de Estado para establecer la adecuación frente a los títulos de imputación y asimismo, las condiciones de interpretación de las categorías del daño antijuridico y la responsabilidad del Estado. Materiales y Métodos: El estudio fue delimitado a partir de la revisión documental de una elección aleatoria de sentencias del Consejo de Estado tomadas de forma no probabilística a través de las categorías de los títulos de imputación que se presentaron en una reconstrucción cronológica donde el eje referencia se contrastó en una dimensión analítica del reconocimiento del CAI. Resultados: el estudio evidenció cómo entre los diferentes títulos de imputación aplicables a hechos del CAI existen parámetros que evidencian una transición de omisión institucional que permitía un margen de la concepción del daño antijurídico en un sentido amplio, hacia un margen más limitado fundamentado en un desarrollo más riguroso del principio de legalidad. Conclusiones: La declaración del CAI tuvo una gran incidencia en la forma como se desarrolló la responsabilidad extracontractual del Estado, que al disponer de nuevas categorías de protección generó con ello más seguridad jurídica, pero, que a su vez limitó interpretaciones amplias del daño antijurídico.
Aortic valve reconstruction surgery. Operative results from a Peruvian Cohort Running tittle: AVrec Surgery
Authors: Ríos-Ortega Josías C. , Aranda-Pretell Necemio , Talledo-Paredes Luisa , Davila-Durand Manuel , Reyes-Torres Andres , Pérez-Valverde Yemmy , Morón-Castro Julio
Published: January 2022

Background Aortic valve replacement is the gold standard
treatment for severe symptomatic aortic valve disease. Recently, aortic
valve reconstruction surgery (Ozaki procedure) emerges as a surgical
alternative with good results in the medium term. Methods We
retrospectively analyzed 38 patients who underwent aortic valve
reconstruction surgery between January 2018 and June 2020 in a national
reference center in Lima, Peru. The median age was 62 years,
interquartile range 25. The main indication for surgery was aortic valve
stenosis (63.1%), in most cases due to bicuspid valve (19 patients,
50%). Twenty-two (58%) patients had another pathology with surgical
indication associated to AV disease, 8(21%) had dilatation of the
ascending aorta with indication for replacement. Results One
in-hospital death occurred (1/38, 2.6%) due to perioperative myocardial
infarction. There was a significant reduction in the medians of the peak
(66mmHg, CI95%=52.5-81.3 vs 15mmHg, CI95%=12.1-17.5,
p<0.0001) and mean (41mmHg CI95%=31.8-50.1 vs 8mmHg,
CI95%=6.0-9.6, p<0.0001) aortic valve gradients when we
compared baseline characteristics with first 30-days results. In an
average of 19 (±8.9) months of follow-up, survival, reoperation-free
survival for valve dysfunction, and survival free of AV
insufficiency> II were 94.6%, 94.6% y 91.7%,
respectively. Significant reduction in the medians of the peak (66mmHg,
CI95%=52.5-81.3 vs 14mmHg, CI95%=10.9-17.6, p<0.0001) and
mean (41mmHg CI95%=31.8-50.1 vs 7mmHg, CI95%=5.2-9.1,
p<0.0001) aortic valve gradients were maintained.
Conclusions Mid-term outcome follow-up of aortic valve
reconstruction surgery showed optimal results in term of mortality,
reoperation free survival and hemodynamic characteristics of the
neo-aortic valve.
Insights from a rare myeloproliferative neoplasm with coexisting BCR-ABL1 fusion gene, CALR and TET2 mutations treated with nilotinib and ruxolitinib
Authors: Huo Li , Xie Jundan , Wang Qian , Shen Hongjie , Ding Zixuan , Wen Lijun , Zeng Zhao , Xu Yi , Ruan Changgeng , Chen Suning , Xue Mengxing
Published: January 2022

Myeloproliferative neoplasms (MPNs) with concurrent BCR-ABL1 fusion gene
and CALR mutation are especially rare.We report a patient with
coexisting BCR-ABL1 fusion gene, CALR and TET2 mutations who was treated
with the combination of the second-generation TKI nilotinib and
JAK1/JAK2 inhibitor ruxolitinib.
Presentación. De la Ciberpragmática a la pragmática de internet
Authors: Cantamutto Lucía , Vela Delfa Cristina
Published: January 2022

Resumen
Features of blood clotting system in girls with abnormal uterine bleeding of the puberty period
Authors: Emelyanova A. V. , Shaytor V. M. , Revnova M. O. , Shaytor D. I. , Airapetian E. Yu.
Published: January 2022

Objective: to evaluate the blood clotting system based on laboratory data in adolescent girls with uterine bleeding of the puberty period (MCPP). The study included 151 girls from 9 to 17 years old, of which 101 patients with MСPP and 50 patients with somatic pathology who do not suffer from MСPP. All patients underwent laboratory tests of blood coagulation parameters. The results of the study revealed lower values of the prothrombin index (PTI) and a tendency of compensatory increase in fibrinogen levels with a decrease in Duke bleeding time in the period of acute uterine bleeding in patients of the main group. In patients with MСPP, the threshold values of the blood clotting system parameters for the occurrence of uterine bleeding were determined, these are the level of PTI≤71.25%, fibrinogen ≤4.45 g/l, bleeding time according to Duque <2.38 min (p<0,05 according to the criterion χ2). The analysis of the obtained results indicates the presence of signs of insufficiency of the vascular-platelet hemostasis link in girls with MCPP.
Theoretical approaches to the development of corporate social responsibility of business
Authors: KLYCHOVA Guzaliya S. , SALAKHUTDINOVA El'vira R.
Published: January 2022

Subject. This article discusses the problematic aspects associated with theoretical approaches to the formation of corporate social responsibility of organizations of various forms of management.
Objectives. The article aims to study the theoretical foundations of the formation and development of corporate social responsibility of business.
Methods. For the study, we used the methods of comparison, systematization, and data generalization.
Results. The article reveals problematic aspects of formation and presentation of corporate responsibility of business in modern economic conditions. The article offers a classification of indicators of corporate social responsibility, indicators for assessing the effectiveness of socially important business, and it presents principles according to the International Standard ISO 26000:2010 Guidance on Social Responsibility.
Conclusions and Relevance. The role and significance of corporate social responsibility of business should be evaluated not only from the point of view of contribution to socially significant and environmental projects, but from the point of view of economic efficiency for the business itself as well. The results of the study can be applied in the development of the theory of corporate social responsibility and in the practice of socio-economic activities of an economic entity in the context of sustainable business development.
Psychological Well-Being amongst Cancer Palliative Care Professionals working in Bengaluru, India
Authors: Kaur Amanpreet , Sharma Mahendra P. , Chaturvedi Santosh K.
Published: January 2022

Objectives:

Increased levels of psychological distress and burnout in cancer palliative care professionals have implications on their psychological well-being, quality of patient care they provide and for their employing organisations. There is a dearth of studies on psychological well-being with no published study available on psychological well-being amongst cancer palliative care professionals in India. The aim of the present study was to assess psychological well-being amongst cancer palliative care professionals.

Materials and Methods:

The study was cross-sectional and quantitative which was carried out at four cancer palliative care centers (one hospice and three hospitals) in Bengaluru city of India. The tools sociodemographic and professional datasheet and psychological well-being (PWB-20) scale were administered with 65 participants (Mean Age = 32.5, SD = 11.78). Purposive sampling method was used to recruit the participants working full-time at respective centers after obtaining permissions and ethical approvals. Descriptive, correlational, and inferential analysis of the quantitative data was carried out based on normality of the distribution.

Results:

The results revealed above average levels of self-acceptance and engagement and growth, below average levels of mastery and competence, while average levels of positive relations and PWB (total score). Significant differences in PWB domains based on age (P < 0.05) and self-care practices (P < 0.05) were seen. Sense of engagement and growth was found to be positively correlated with age and income earned per month (P = 0.01).

Conclusion:

Findings from the present study suggest that cancer palliative care professionals had moderate levels of PWB with implications in training and future research.
Hemorrhagic brain metastasis from small-cell carcinoma of the urinary bladder
Authors: Maeshima Kazuhide , Sasaki Takahiro , Yamoto Toshikazu , Fukai Junya , Nishibayashi Hiroki , Nakao Naoyuki
Published: January 2022

Background:

Small-cell carcinoma of the urinary bladder (SCCB) accounts for 1% of all bladder tumors. We present a rare case of hemorrhagic metastatic brain tumor from SCCB diagnosed by navigation-guided endoscopic biopsy.

Case Description:

A 76-year-old man presented with sudden onset of aphasia and right hemiplegia from 3 weeks previously. He had a medical history of prostate cancer and SCCB. Computed tomography showed a mixed density mass in the left basal ganglia. On magnetic resonance imaging, the mass showed mixed intensity in both T1-weighted images and T2-weighted images, suggesting subacute hemorrhage. The mass was partially enhanced with gadolinium. The patient underwent endoscopic hematoma evacuation and partial removal of the tumor. Histopathological diagnosis was neuroendocrine carcinoma, which was consistent with SCCB metastasis. After surgery, the patient underwent whole-brain radiation therapy of 30 Gy. His general condition gradually deteriorated, however, and he died 4 months after surgery.

Conclusion:

Our patient had a rare case of brain metastasis derived from SCCB which presented with cerebral hemorrhage. Navigation-guided endoscopic biopsy was useful for the diagnostic sampling of deep localized brain tumors with hemorrhage.
Being Elder is Not Worst: Studi Tentang Proyeksi Pemuda Pada dan Saat Menjadi Lansia
Authors: Zuliani Siti , Nuqul Fathul Lubabin
Published: January 2022

The projection of becoming elderly is one of the things that young people rarely think about in facing the next phase. The purpose of this study was to analyze the projections of youth into the elderly, which include attitudes and readiness to care for the elderly, youth expectations when they become elderly, and the efforts made to face the elderly. The research involves 224 people, about 17-24 years of age. The gender distribution was 75 males and 149 females. Data collection using an open questionnaire. The analysis used is theme/categorization analysis and descriptive analysis. The results show that youth who care for the elderly are not necessarily ready to become elderly. Both prepared and unprepared, both groups of subjects hope to have a prosperous life, have financial independence, and have a happy family.
Ilościowa analiza dynamiki zmian zróżnicowania kapitału ludzkiego województw oparta na łańcuchach Markowa
Authors: Szczepaniak Daniela
Published: January 2022

Przedmiot badań: Regionalna analiza zróżnicowania poziomu kapitału ludzkiego w Polsce w la­tach 2006–2018. 1

Cel badawczy: Dynamiczna analiza zróżnicowania województw pod względem poziomu kapita­łu ludzkiego oparta na łańcuchach przejścia Markowa.

Metoda badawcza: W badaniu wykorzystano metody ilościowe. Do analizy zróżnicowania wo­jewództw pod względem poziomu kapitału ludzkiego użyto metod taksonomicznych. Wartości wskaźnika taksonomicznego otrzymano trzema metodami: w oparciu o odległość w przestrzeni euklidesowej (OE), miejskiej (OM) oraz wskaźnik maksymalizujący sumę współczynników ko­relacji liniowej pomiędzy wskaźnikiem a jego składowymi (SK). Natomiast do dynamicznej ana­lizy zmian zróżnicowania poziomu kapitału ludzkiego zastosowano łańcuchy przejścia Markowa.

Wyniki: Na podstawie przeprowadzonego badania wykazano, iż najwyższym poziomem kapi­tału ludzkiego charakteryzowały się województwa małopolskie oraz mazowieckie, najniższym natomiast lubuskie oraz kujawsko-pomorskie. Ponadto, stwierdzono również, że w analizowa­nym okresie najczęściej występowały ruchy województw pomiędzy drugą a trzecią grupą kwar­tylową, najrzadziej natomiast obserwowano zmiany w pierwszej grupie kwartylowej. Oznacza to, że pierwsza grupa kwartylowa była najbardziej hermetyczną, a należały do niej najczęściej województwa: małopolskie, mazowieckie, pomorskie oraz wielkopolskie. Równie ważnym wnioskiem płynącym z przeprowadzonego badania jest fakt, że w województwie podkarpackim zaobserwowano wzrost poziomu kapitału ludzkiego w latach 2006–2018, natomiast spadek zano­towano w województwie łódzkim oraz warmińsko-mazurskim.