bluuebunny/crossref_metadata_2025 huggingface dataset:
Identify and Assess Hydropower Project’s Multidimensional Social Impacts with Rough Set and Projection Pursuit Model
Authors: An Hui , Yang Wenjing , Huang Jin , Huang Ai , Wan Zhongchi , An Min
Published: November 2020

To realize the coordinated and sustainable development of hydropower projects and regional society, comprehensively evaluating hydropower projects’ influence is critical. Usually, hydropower project development has an impact on environmental geology and social and regional cultural development. Based on comprehensive consideration of complicated geological conditions, fragile ecological environment, resettlement of reservoir area, and other factors of future hydropower development in each country, we have constructed a comprehensive evaluation index system of hydropower projects, including 4 first-level indicators of social economy, environment, safety, and fairness, which contain 26 second-level indicators. To solve the problem that existing models cannot evaluate dynamic nonlinear optimization, a projection pursuit model is constructed by using rough set reduction theory to simplify the index. Then, an accelerated genetic algorithm based on real number coding is used to solve the model and empirical study is carried out with the Y hydropower station as a sample. The evaluation results show that the evaluation index system and assessment model constructed in our paper effectively reduce the subjectivity of index weight. Applying our model to the social impact assessment (SIA) of related international hydropower projects can not only comprehensively analyze the social impact of hydropower projects but also identify important social influencing factors and effectively analyze the social impact level of each dimension. Furthermore, SIA assessment can be conducive to project decision-making, avoiding social risks and social stability.
Analysis of the Molecular Mechanisms of the Effects of Prunella vulgaris against Subacute Thyroiditis Based on Network Pharmacology
Authors: Shen Xin , Yang Rui , An Jianpeng , Zhong Xia
Published: November 2020

Prunella vulgaris (PV) has a long history of application in traditional Chinese and Western medicine as a remedy for the treatment of subacute thyroiditis (SAT). This study applied network pharmacology to elucidate the mechanism of the effects of PV against SAT. Components of the potential therapeutic targets of PV and SAT‐related targets were retrieved from databases. To construct a protein‐protein interaction (PPI) network, the intersection of SAT‐related targets and PV‐related targets was input into the STRING platform. Gene ontology (GO) analysis and KEGG pathway enrichment analysis were carried out using the DAVID database. Networks were constructed by Cytoscape for visualization. The results showed that a total of 11 compounds were identified according to the pharmacokinetic parameters of ADME. A total of 126 PV‐related targets and 2207 SAT‐related targets were collected, and 83 overlapping targets were subsequently obtained. The results of the KEGG pathway and compound‐target‐pathway (C‐T‐P) network analysis suggested that the anti‐SAT effect of PV mainly occurs through quercetin, luteolin, kaempferol, and beta‐sitosterol and is most closely associated with their regulation of inflammation and apoptosis by targeting the PIK3CG, MAPK1, MAPK14, TNF, and PTGS2 proteins and the PI3K‐Akt and TNF signaling pathways. The study demonstrated that quercetin, luteolin, kaempferol, and beta‐sitosterol in PV may play a major role in the treatment of SAT, which was associated with the regulation of inflammation and apoptosis, by targeting the PI3K‐Akt and TNF signaling pathways.
Conditional Relative Survival and Competing Mortality of Patients with Prostate Cancer in Korea: A Nationwide Cohort Study
Authors: Park Jinsung , Han Kyungdo , Shin Dong Wook , Park Sang Hyun , Shin Hyun Bin
Published: November 2020

Background:

Conditional relative survival (CRS) and competing mortality are important survivorship issues after cancer treatment. We aimed to investigate them among patients with prostate cancer treated by various modalities.

Methods:

Using a nationwide population-based database, we calculated 5-year CRS conditioned on 1 through 5 years survival after diagnosis. These rates were stratified by age, sex, socioeconomic status, comorbidities, and treatment received. Cause of death and estimated cause-specific mortality were also described and considered with competing risks.

Results:

A total of 81,773 patients newly diagnosed with primary prostate cancer from 2007 to 2013 were identified. The 5-year CRS was 81.1% at baseline, but increased gradually up to 95.4% at 4 years and exceeded 100% at 5 years after diagnosis, suggesting no excess mortality compared with the general population. However, this pattern differed by treatment received. Patients who underwent androgen deprivation therapy showed 5-year CRS of only 88.4% at 5 years after diagnosis, implying persistent excess mortality. Prostate cancer constituted around one-third of deaths, while other cancers were the main cause of death within <2 years after diagnosis. Noncancer-related deaths, including cardiovascular disease and respiratory disease, increased with time since diagnosis.

Conclusions:

CRS rates for patients with prostate cancer improved over time and exceeded that of the general population at 5 years. Other cancers were the main cause of death in the earlier survivorship phase, and deaths from noncancer causes gradually increased over time.

Impact:

Our findings will help patients and clinicians make evidence-based decisions on the basis of a patient's dynamic risk profile.
CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function
Authors: Boucher Justin C. , Li Gongbo , Kotani Hiroshi , Cabral Maria L. , Morrissey Dylan , Lee Sae Bom , Spitler Kristen , Beatty Nolan J. , Cervantes Estelle V. , Shrestha Bishwas , Yu Bin , Kazi Aslamuzzaman , Wang Xuefeng , Sebti Said M. , Davila Marco L.
Published: November 2020

An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive high T-cell activation, which leads to exhaustion and shortened persistence. This work led us to hypothesize that by incorporating null mutations of CD28 subdomains (YMNM, PRRP, or PYAP), we could optimize CAR T-cell costimulation and enhance function. In vivo, we found that mice given CAR T cells with only a PYAP CD28 endodomain had a significant survival advantage, with 100% of mice alive after 62 days compared with 50% for mice with an unmutated endodomain. We observed that mutant CAR T cells remained more sensitive to antigen after ex vivo antigen and PD-L1 stimulation, as demonstrated by increased cytokine production. The mutant CAR T cells also had a reduction of exhaustion-related transcription factors and genes such as Nfatc1, Nr42a, and Pdcd1. Our results demonstrated that CAR T cells with a mutant CD28 endodomain have better survival and function. This work allows for the development of enhanced CAR T-cell therapies by optimizing CAR T-cell costimulation.
Negociação e conflito no direito internacional: cinco mil anos de registro da história
Authors: Casella Paulo Borba
Published: November 2020

‘Negociação’ e ‘conflito’ seriam termos essenciais para resumir, em poucas palavras, o sentido da evolução do Direito Internacional. Na sua longa, diversificada e complexa trajetória na história da humanidade, o Direito Internacional se estende por mais de cinco mil anos, desde quando se conservam registros históricos por escrito. Não por acaso, o Direito Internacional se faz presente e necessário, tanto no encaminhamento de posições divergentes, tendendo a alcançar composição, se não amigável, ao menos pacífica – em todas as esferas e manifestações possíveis da ‘negociação’, desde sempre e em toda parte, como também o Direito Internacional se inscreve e tem papel relevante a desempenhar, quando estes mecanismos ‘pacíficos’, quer de cunho jurídico ou diplomático, não conseguem dar conta das questões presentes (“jus ad bellum”), e pode ocorrer a necessidade de se ter de passar quer a meios coercitivos para enfrentamento de divergências, ou mesmo chegar ao extremo do conflito armado (“jus in bello”) – coarctado pelo Direito Internacional vigente às hipóteses de “legítima defesa”, como regulado no art. 51 da Carta da ONU. Como em outros ramos do conhecimento e da atividade humana, os conceitos têm de ser precisados, também no Direito Internacional: seus conteúdos precisam ser claramente delimitados, para que sejam efetivamente entendidos e aplicados. Já advertia Tucídides (c. 465 – c. 395 a.C.), na História da guerra do Peloponeso, “o sentido normal das palavras, em relação aos atos, muda segundo as veleidades dos homens”.
Tribunais da sociedade: um estudo das estruturas decisórias do direito por meio dos sistemas organizacionais
Authors: Barros Marco Antonio Loschiavo Leme de
Published: November 2020

O artigo descreve, inspirado pela teoria dos sistemas sociais de Niklas Luhmann, a dinâmica dos tribunais na sociedade moderna. É destacado as implicações da constatação que tribunais podem ser observados tanto como centro do sistema jurídico quanto como uma organização periférica do sistema político e do econômico. Trata-se, em verdade, de observar os tribunais da sociedade. Por ocasião desta observação, uma nova tipologia é apresentada para lidar com a descrição dos tribunais nas sociedades modernas, tais como as ideias de cortes originais, deferenciais, consequencialistas e catalisadoras. Nesse sentido o texto avança em diferentes estudos das teorias das organizações para sustentar uma perspectiva funcionalista que permite lidar com o fato organizacional social. Trata-se de uma observação da atuação do tribunal por sua própria estrutura e função, não se limitando às operações de outros sistemas funcionais, como em soluções descritivas sobre as cortes como instâncias de controle ou de programação.
Myocardial Injury in Severe COVID-19 Compared With Non–COVID-19 Acute Respiratory Distress Syndrome
Authors: Metkus Thomas S. , Sokoll Lori J. , Barth Andreas S. , Czarny Matthew J. , Hays Allison G. , Lowenstein Charles J. , Michos Erin D. , Nolley Eric P. , Post Wendy S. , Resar Jon R. , Thiemann David R. , Trost Jeffrey C. , Hasan Rani K.
Published: November 2020

Background:

Knowledge gaps remain in the epidemiology and clinical implications of myocardial injury in coronavirus disease 2019 (COVID-19). We aimed to determine the prevalence and outcomes of myocardial injury in severe COVID-19 compared with acute respiratory distress syndrome (ARDS) unrelated to COVID-19.

Methods:

We included intubated patients with COVID-19 from 5 hospitals between March 15 and June 11, 2020, with troponin levels assessed. We compared them with patients from a cohort study of myocardial injury in ARDS and performed survival analysis with primary outcome of in-hospital death associated with myocardial injury. In addition, we performed linear regression to identify clinical factors associated with myocardial injury in COVID-19.

Results:

Of 243 intubated patients with COVID-19, 51% had troponin levels above the upper limit of normal. Chronic kidney disease, lactate, ferritin, and fibrinogen were associated with myocardial injury. Mortality was 22.7% among patients with COVID-19 with troponin under the upper limit of normal and 61.5% for those with troponin levels >10 times the upper limit of normal (
P
<0.001). The association of myocardial injury with mortality was not statistically significant after adjusting for age, sex, and multisystem organ dysfunction. Compared with patients with ARDS without COVID-19, patients with COVID-19 were older and had higher creatinine levels and less favorable vital signs. After adjustment, COVID-19–related ARDS was associated with lower odds of myocardial injury compared with non–COVID-19–related ARDS (odds ratio, 0.55 [95% CI, 0.36–0.84];
P
=0.005).

Conclusions:

Myocardial injury in severe COVID-19 is a function of baseline comorbidities, advanced age, and multisystem organ dysfunction, similar to traditional ARDS. The adverse prognosis of myocardial injury in COVID-19 relates largely to multisystem organ involvement and critical illness.
Long‐Term Effectiveness and Safety of Initiating Statin Therapy After Index Revascularization In Patients With Peripheral Arterial Occlusive Disease
Authors: Peters Frederik , Kuchenbecker Jenny , Kreutzburg Thea , Marschall Ursula , Debus E. Sebastian , Behrendt Christian‐Alexander
Published: November 2020

Background

An increasing number of patients with a peripheral arterial occlusive disease were put on statins during the past years. This study assessed whether statin therapy was effective and safe for these new users.

Methods and Results

Using health insurance claims data from Germany’s second‐largest insurance fund, BARMER, we identified patients with peripheral arterial occlusive disease who had index revascularization between 2008 and 2018 without prior statin therapy. We compared patients with and without statin therapy in addition to antithrombotics during the first quarter after discharge (new users versus nonusers). Outcomes were all‐cause mortality, cardiovascular events, and incident major amputation for effectiveness and incident diabetes mellitus and incident myopathy for safety. Propensity score matching was used to balance the study groups. All analyses were stratified into patients with chronic limb‐threatening ischemia and intermittent claudication. A total of 22 208 patients (mean age 71.1 years and 50.3% women) were included in the study. In 10 922 matched patients, statin initiation was associated with lower all‐cause mortality (chronic limb‐threatening ischemia: hazard ratio [HR], 0.75 [95% CI, 0.68–0.84]; intermittent claudication: HR, 0.80 [95% CI, 0.70–0.92]), lower risk of major amputation in patients with chronic limb‐threatening ischemia (HR, 0.73; 95% CI, 0.58–0.93) and lower risk of cardiovascular events (hazard ratio, 0.80; 95% CI, 0.70–0.92) in patients with intermittent claudication during 5 years of follow‐up. Safety outcomes did not differ among the study groups.

Conclusions

Initiating statin therapy in patients with peripheral arterial occlusive disease after index revascularization is efficient and safe with an effect size comparable to earlier studies. Awareness campaigns for evidence‐based optimal pharmacological treatment among patients are recommended.
Synthesizing Parallel Data of User-Generated Texts with Zero-Shot Neural Machine Translation
Authors: Marie Benjamin , Fujita Atsushi
Published: November 2020

Neural machine translation (NMT) systems are usually trained on clean parallel data. They can perform very well for translating clean in-domain texts. However, as demonstrated by previous work, the translation quality significantly worsens when translating noisy texts, such as user-generated texts (UGT) from online social media. Given the lack of parallel data of UGT that can be used to train or adapt NMT systems, we synthesize parallel data of UGT, exploiting monolingual data of UGT through crosslingual language model pre-training and zero-shot NMT systems. This paper presents two different but complementary approaches: One alters given clean parallel data into UGT-like parallel data whereas the other generates translations from monolingual data of UGT. On the MTNT translation tasks, we show that our synthesized parallel data can lead to better NMT systems for UGT while making them more robust in translating texts from various domains and styles.
Tradizione e prassi editoriale dei testi etiopici: un breve sguardo d’insieme
Authors: Bausi Alessandro
Published: November 2020

The tradition of Ethiopic texts, although characterized by a particular temporal articulation of its own that distinguishes texts from Antiquity and Late Antiquity and texts of the medieval age, has been and is the object of study of a philology that shares the history and paradigms of the other philologies of the Christian East; like these, throughout the course of the twentieth century and almost without exception, the criterion unwittingly selected and adopted as the norm of the ‘base manuscript’ dominated. Unlike the other philologies, however, in the last two decades of the twentieth century, the Italian school of Ethiopian studies renewed by Paolo Marrassini and eventually appreciated also in Europe and in Ethiopia, has largely applied the Neo-Lachmannian reconstructive stemmatic method to Ethiopic texts. Even in the absence of universal consensus, this method is still the only one that has prompted a theoretical-methodological reflection on the phenomenology of Ethiopic texts.
Investigate the Effect of miR-22 on the Apoptosis of Coronary Heart Disease Cells Through the Wnt-1 Pathway Based on Nano-Silica-Induced Rat Models
Authors: Wei Fangjing , Ren Baojun , Han Wei , Guan Hong , Jing Guoqiang , Wang Min
Published: November 2020

In this paper, by examining the toxicity of nano-silica to coronary heart disease cells, we explored the apoptosis of rat myocardial cells induced by nano-silica, and explored the effect of apoptosis on cells during the process of myocardial cytotoxicity induced by nano-silica. This
article selects rat cardiomyocytes as the research object and conducts a group control experiment. A control group is set up with cells that are not stained with nano-silica. Different concentrations of nanosilica suspensions are applied to rat cells and detected by CCK-8 method. Cell survival
rate after exposure to different concentrations of cells is used to determine the most stable exposure time and concentration. We used flow cytometry to detect intracellular reactive oxygen species and apoptotic rates, and used Western Blot to detect the expression of proteins that affect
apoptosis. Finally, we investigated the effect of the Wnt signaling pathway on coronary heart disease. The Wnt signaling pathway regulates the development of the heart and blood vessels. In the treatment of cardiovascular disease, this pathway will be activated again to play a regulatory role.
We conclude that nano-silica can induce cytotoxicity in rat myocardial cells through the Wnt-1 pathway, and nanosilica can induce myocardial cell apoptosis through the Wnt-1 pathway.
Preparation of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Nanofiber Catheter and Its Mechanism of Nerve Injury in Patients with Cervical Spine Injury
Authors: Chen Xuan , Zhao Haiyang , Li Ye
Published: November 2020

At present, surgical suture treatment can be performed for spinal patients after nerve injury, but nerve regeneration and functional recovery require comprehensive treatment including drug treatment. However, there is still a lack of adjuvant therapeutic drugs that can effectively promote
nerve regeneration and functional recovery. Drug treatment after nerve injury is the basis of nerve injury treatment and an important supplement to surgical treatment. Finding an effective method for treating spinal nerve injury and studying its mechanism of action may have important basic
and clinical significance. The nanofiber catheter material simulates the nano/sub-micron level collagen fiber bundle structure of cells in the body, so it has been more and more widely used in the field of tissue engineering. Therefore, in this study, PHBV nanofiber catheter was successfully
prepared by electrostatic spinning method, and the nanofiber catheter was characterized by SEM and DSC tests. The PHBV nanofiber catheter prepared by this research method has excellent characteristics such as porosity, large specific surface area, stable structure, thermal stability, and good
mechanical properties. At the same time, adult male SD rats were selected to establish an animal model of cervical spine injury in this experiment. The expressions of three inflammation-related factors (IL-1α, IL-10 and TNF-1) were analyzed by ELISA. The results showed that in
the spinal injury group, the expression of the three inflammatory factors all showed a significant increase over time and then reached a peak, then decreased and stabilized. This showed that the PHBV nanofiber catheter repairs cervical spine injury by affecting the inflammatory response, which
is conducive to repairing cervical spine injury. RT-PCR was used to detect the expression of CNTF, GAP-43, and Tubulin-related proteins. During the neural regeneration process in rats, the expressions of both backbone proteins continued to be expressed, and they were first up-regulated and
then flattened. This indicated that in the early stage of neural regeneration, a large number of skeletal proteins are synthesized, and they continue to be expressed at low levels over time, laying a foundation for the axon skeleton reconstruction.
Targeted Therapeutic Effect of Bavachinin Nanospheres on Pathological Site of Chronic Asthmatic Mice Model
Authors: Zhang Chunxia , Qin Qian , Li Hongle
Published: November 2020

Steroids are the main drugs currently used to treat asthma. However, the toxic and side effects of these drugs and the tolerance of the drugs due to long-term administration are still problems in the clinical treatment of asthma. Bavachinin has a good effect in the treatment of mouse
asthma models, and it can effectively inhibit the expression of a variety of cytokines. However, it is extremely difficult to dissolve in water, has low bioavailability, and is quickly cleared in the blood. These characteristics limit its clinical application potential. In this study, nanotechnology
was used to construct an effective oral drug delivery system. Through analysis of serum-related antibodies and cytokines, the system showed significant therapeutic effects on asthma-positive groups. Far-infrared imaging results showed that the system has a good targeted enrichment effect on
pathological parts, while showing lower toxicity and higher therapeutic effect. Whether it is the splenocyte flow typing or the analysis of lung tissue, the system has verified the excellent treatment, and through the observation of paraffin sections of lung tissue, it was found that the bronchial
morphology returned to normal after drug treatment, and the leakage of inflammatory cells was significantly reduced.
Effect of Composite Nanoparticle CeO2 on Myocardial Ischemic Re-Infusion of Cardio Myocyte Apoptosis in Mouse
Authors: Wang Chengbin , Ding Lin , Zhao Jiamei , Cao Beibei , He Mingwei
Published: November 2020

The myocardial I/R damage is very complicated. Apoptosis is considered to its a critical mechanism. During the cardiac muscle I/R process, oxygen-free radicals play a pivotal role. Arrhythmias, as well as enlargement of the area of myocardial infarction after cardiac muscle I/R process,
are caused by adequate blast generated O2- ion free radicals. During the ischemia-reperfusion process, a large amount of O2- ion free radicals destroyed the cell structure, and it undergoes lipid peroxidation with unsaturated fatty acids that contain a large number of
phospholipids in the cell membrane, causing membrane proteins such as ion channels and enzymes on the cell membrane. The activity of cell is reduced, which affects the function of cell membrane and organelle membrane, destroys its integrity and reduces fluidity.We observed the effects of cerium
dioxide nanoparticles on glutathione peroxidase as well as superoxide dismutase, also propionate in myocardial tissue of I/R injury in the mouse. Its effects of malondialdehyde and apoptosis were explored to see its protective effect and to provide more preventive measures for ischemia-reperfusion
injury.
Preparation of Simvastatin Loaded Nanostructured Lipid Carriers and Its Therapeutic Effect on Patients with Severe Acute Lung Injury
Authors: Yan Xijiao , Zhang Wenkai , Cheng Xiangli , Hou Linyi
Published: November 2020

Acute lung injury (ALI) is a critical illness but have not effective therapeutic modalities currently where recent studies have revealed anti-inflammatory pleiotropic effects and plaque stabilizing effects of statins so the purpose of this work is preparation of simvastatin loaded nanostructured
lipid carriers (simvastatin-NLCs) and investigation of its efficacy in lung injury mice. The simvastatin-NLCs was prepared by thermal melting-low temperature curing method and the quality evaluation was performed with particle size distribution, encapsulation efficiency, and drug loading.
Sixty C57BL/6 mice were divided into three experimental groups: blank group model group and simvastatin treated group. Simvastatin was administered intraperitoneally immediately after the LPS injection in animals of the treated group at a dose of 20 mg/kg/day. Lung injury degree and the protective
effects of simvastatin against LPS-induced lung injury were assessed at the time-points of 24, 48, and 72 h post injection, and the in vivo efficacy of simvastatin-NLCs on mice was investigated. The average particle size of simvastatin-NLCs was (102.1±42.2) nm, the encapsulation
efficiency was (94.6±2.5)%, and the drug loading was (5.78±0.57)%. After 24 hours of administration, the data shows that simvastatin-NLCs inhibit the levels of IL-6 and TNF-α inflammatory factor in the lungs of mice.
Preparation of Nanocomposite Peptide and Its Inhibitory Effect on Myocardial Injury in Type-II Diabetic Rats
Authors: Zhang Yang , Zhuang Shaowei , Jiang Shengyang , Zhang Jiehan , Chen Yu
Published: November 2020

Complications of diabetes are the main cause of death and disability in diabetic patients. Cardiovascular diseases, especially diabetic cardiomyopathy, are one of the major complications and causes of death in type 2 diabetes. Peptide drugs have a better effect on improving cellular
oxidative damage, reducing tissue inflammation and inhibiting intracellular calcium overload. The application of nanotechnology to the preparation of peptide drugs and myocardial injury can effectively improve myocardial stun, arrhythmia and myocardial systolic dysfunction in patients with
type 2 diabetes. The use of nanotechnology to develop more stable Glucagon-like peptide 1 analogues or sustained-release preparations, improve patient compliance and improve the efficacy of diabetes, is of great significance for the prevention and treatment of diabetic cardiomyopathy. Therefore,
this study used nanotechnology to prepare PLGA-GLP-1 nanoparticles using polyglycolic acid glycolic acid as a drug carrier, which achieved long-acting drug and its morphology by transmission electron microscopy. At the same time, this study explored the anti-cardiomyocyte injury and anti-myocardial
damage of PLGA-GLP-1 nanocomposite peptide and its molecular mechanism by using animal models and cell models. Experimental studies have shown that PLGA-GLP-1 nanocomposite peptide has a protective effect on myocardial injury in diabetic rats. Its mechanism is related to the PLGA-GLP-1 nanocomposite
peptide enhancing the body’s antioxidant capacity, anti-cardiomyocyte apoptosis, and promoting mitochondrial DNA repair in cardiomyocytes.
Preparation of Nano Zinc Particles and Evaluation of Its Application in Mouse Myocardial Infarction Model
Authors: Song Yue , Wu Lisong , Cao Jian , Song Bangrong
Published: November 2020

Nanometer zinc particles were synthesized by orthogonal test with manganese chloride, iron chloride and zinc sulfate as raw materials and NaOH as coprecipitating agent. The optimum synthesis conditions of coprecipitation method were obtained and the samples were characterized by various
means. In this experiment, the SV, EF, FS, lvaws, lvawd, lvpws and lvpwd of left ventricle in mice with myocardial infarction were decreased, while the LVEDd, lveds and lvevs were increased in the environment exposed to ultrafine zinc nanoparticles, which proved that exposure to ultrafine
zinc nanoparticles could lead to the enlargement of left ventricle, the thinning of ventricular wall, and the decrease of cardiac systolic and diastolic function. Further study on the heart tissue sections showed that the normal left ventricular myocardium of mice exposed to ultrafine zinc
nanoparticles decreased, apoptotic cells increased, collagen content increased significantly, and myocardial fibrosis intensified. At the same time, WGA staining results of myocardial cell membrane showed that inhalation of ultra-fine nano zinc particles increased the size of myocardial infarction
cells and disordered cell arrangement, which further proved that inhalation of ultra-fine nano zinc particles accelerated left ventricular pathological remodeling. The results of this study prove that the ultra-fine zinc nanoparticles in the air play an important role in the structural remodeling
of myocardial infarction heart, and provide a theoretical basis for formulating targeted policies to control air pollution.
Evaluation Preparation of Apatinib-Loaded Polymer Nanoparticles and Its Effect in the Treatment of Advanced Ovarian Cancer
Authors: Guo Jinzhu , Yue Hua , Wang Yanjun , Du Xiujuan
Published: November 2020

Ovarian cancer is a common gynecological malignant tumor, second only to cervical cancer and uterine body cancer. In China, ovarian cancer has the highest mortality rate in gynecological tumors. Due to the rapid spread of cancer cells, the prognosis is relatively poor. Because the ovarian
epithelial cancer is relatively insidious, there are no obvious clinical manifestations in the early stage. At present, apatinib chemotherapy is widely used, which can reduce the disease of patients by inhibiting the migration and proliferation of vascular endothelial cells. Fluorescence imaging
is widely used in biomedical imaging. Organic fluorescent dyes are stable in nature and can be linked to a variety of molecules. They are often used in targeted imaging and therapeutic research. A cyanine dye is an organic molecule formed by two nitrogen-containing aromatic heterocycles connected
by a polymethine bridge. Because neither MR contrast agents nor fluorescent dyes are targeted, specific biomolecules and contrast agents are often used in the research to diagnose and treat tumors. In this paper, a polymer nanoparticle loaded with apatinib was prepared and its therapeutic
effect in advanced ovarian cancer was explored. The results show that nanoparticles loaded with apatinib are more effective than ordinary therapeutic drugs.
Poly(lactic-co-glycolic acid)-Chitosan–Gelatin Composite Nanomaterials for the Treatment of Diabetic Foot Ulcer Wound Infection
Authors: Liu Zhangyi , Peng Yue , Yang Lumeng , Zhang Guowu
Published: November 2020

In this experiment, a solid carrier was prepared with PLGA, gelatin, and chitosan as the main raw materials, so that BMSCs could exert their repairing effect directly in the ulcer area under the stimulation of Klotho protein. We chose to use electrospun PLGA as the main technical means
to provide suitable adhesion growth environment for BMSCs by preparing PLGA nanofibers. At the same time, PLGA nanofibers are also a controlled release material, so that Klotho protein can remain active, thereby achieving the purpose of stimulating BMSCs for a long time. Through the nano-scale
porous structure provided on the surface of the PLGA film, BMSCs can adhere well to the surface of the material and continuously receive stimulation from the inner Klotho protein. We applied this composite to mice with diabetic ulcers, and verified the effects of Klotho protein and BMSCs on
DFU healing in five groups of mice. From the results, the Klotho+BMSCs group achieved the best healing effect, followed by the Klotho group alone, while the other three groups had no significant difference in healing effects. It is proved that both Klotho and BMSCs can help the healing of
diabetic ulcers, but BMSCs alone cannot survive in harsh environments, and it is difficult to play a normal repair role. The purpose of this study was to investigate the effect of Klotho protein on BMSCs and ECs under high glucose conditions, and to find a suitable carrier for planting BMSCs
on it. At the same time, the material also has a certain sustained release function. We have concluded that Klotho protein can promote the proliferation and migration of BMSCs and ECs under high glucose conditions. When combined with electrospinning technology to prepare a protein that can
release Klotho, it also provides a microstructure suitable for BMSCs adhesion, thereby ensuring that BMSCs can successfully survive. In the end, we artificial Klotho protein can promote angiogenesis in diabetic ulcer areas by protecting BMSCs and ECs, thereby promoting healing of ulcer areas.
Application of Taxol Nanomicelles with Lyp-1 Target in Targeted Therapy of Colon Cancer
Authors: Wen Xinian , Liu Lei , Geng Zhen , He Lifeng
Published: November 2020

As a new type of non-viral gene drug carrier, paclitaxel with Lyp-1 target has unique transmembrane ability due to its unique structure. In this paper, amino acids and surfactants are used to disperse SWCNTs in water, and non-covalent interactions are used to adsorb paclitaxel to the
surface of SWCNTs. DSPE-PEG-Maleimide is then connected to NGR to achieve active targeting. To investigate the effect of NGR-SWCNTs-Paclitaxel on isolated cells, and to observe the antitumor effect of NGR-SWCNTs-Paclitaxel on S180 colon cancer mice in vivo, we provide theoretical and
experimental basis for targeted cancer treatment. The luciferase activity test results showed that mi R-218 mimics had no significant effect on the intensity of the blank reporter plasmid group and p MIR-REPORT/UTR mutant luciferase activity, but in mi R-218 mimics and p MIR-REPORT/UTR Luciferase
activity decreased after co-transfection of wild-type plasmids into cells. The validation results of the luciferase activity analysis system showed that mi R-218 was able to bind to Sp13’UTR. Overexpression of mi R-218 can significantly reduce the expression level of Sp1 protein but
has no significant effect on Sp1 m RNA level, indicating that mi R-218 can target the regulation of Sp1 expression at the translation level.
Study on Multifunctional Composite Nanomaterials for Controlled Drug Release in Biomedicine
Authors: Shen Jia-Yan , Dong Ting , Fang Liang , Ma Jian-Jun , Zeng Li-Hong
Published: November 2020

Nanoscience is a highly comprehensive, interdisciplinary discipline based on many advanced science and technology, and has developed very rapidly in the past few decades. Nanoscience and technology has been widely used in many fields such as biomedicine, materials science, chemistry,
physics, and electronic information engineering. Nanomaterials are widely used due to their many excellent properties such as quantum size effects, small size effects, surface effects, and tunneling effects, and have become hot research areas. It is very suitable as a carrier for antitumor
drug molecules, which is conducive to improving drug efficacy and reducing drugs side effects. After selective functionalization, it is highly possible to achieve the loading and release of multiple drug molecules. Based on the magnetic mesoporous Fe3O4-MSNs composite
nanoparticles, we have modified a series of organosilane coupling agents on its surface. The most commonly used antitumor drug (adriamycin) in clinical was selected as a model to evaluate the loading and release behavior of modified composite nanoparticles Fe3O4-MSNs
on this drug. The results indicate that Fe3O4 is selectively modified after appropriate modification of the silane coupling agent. MSNs carrier can effectively regulate the adsorption and release rate of hydrophilic DOX and hydrophobic PTX, and shows a good drug control
ability.
The Effect of Echocardiography Based on Lipid Nano Contrast Agent on Cardiology Patients with Heart Failure and Atrial Fibrillation
Authors: Wang Lizhong , Xi Jianing , Cao Qian , Jia Yaowen , Zhang Zhenying , Zhang Jianxiu , Miao Guobin
Published: November 2020

This paper discusses the effect and evaluation of echocardiography based on lipid nano contrast agent on patients with heart failure and atrial fibrillation in cardiology department, providing reference for clinical diagnosis and treatment. Fifty two patients with diastolic heart failure
diagnosed by echocardiography were selected for routine echocardiographic examination after optimizing the drug treatment scheme, and then the patients underwent treadmill exercise test and stress echocardiography evaluation. The results of conventional echocardiography and stress echocardiography
after treatment were compared with those before treatment, and the clinical parameters and biochemical indexes before and after treatment were compared. Results after treatment, the clinical symptoms of the patients improved, the level of NT proBNP in the N-terminal forebrain decreased significantly,
and the exercise tolerance increased significantly. Compared with the conventional echocardiography before and after treatment, the left ratio and e′ value of stress echocardiography after treatment increased significantly, while E/e′ decreased significantly. There was no significant
difference in the indexes of general echocardiography before and after treatment. After treatment, positively correlated with the ratio of peak a to peak E. The results show that the sensitivity of stress echocardiography to evaluate ischemic diastolic heart failure has been improved, and
some indexes have clinical significance. Compared with conventional echocardiography, it can effectively evaluate the therapeutic effect of drugs.
The Value of Photo Biological Regulation Based on Nano Semiconductor Laser Technology in the Treatment of Hypertension Fundus Disease
Authors: Hu Xingui , Zhou Linan , Wang Huifeng , Gao Yuanpeng , Gao Yan
Published: November 2020

With the development of nanometer semiconductor laser technology, due to the wide range of photobiological regulation and non-invasive advantages, it is widely used in clinical research, including reducing pain, accelerating wound healing, nerve injury repair and regeneration. Increase
tissue blood flow, improve anxiety and depression, and treat Parkinson’s and retinal diseases. However, in many studies, the role of photobiological regulation is still controversial. There are two main problems, one is that the mechanism of photo biological regulation is not fully understood,
and the other is that the specific parameters are not uniform in different treatments, such as wavelength density, power density, pulse, treatment timing, and number of treatments. In this paper, through the second question, the parameters of low-energy near-infrared light (810 nm semiconductor
laser) in the treatment of fundus diseases are the main research objects. Based on understanding the parameters of low-energy lasers, cyan blue is irradiated with different energy near-infrared light. Data analysis of the actual energy obtained after the retina of the rabbit and observation
and research on the cell morphology of each layer of the retina, to obtain relatively safe treatment parameters for the retina, provide theoretical data for near-infrared light in the treatment of clinical fundus disease, and make it safer to use in clinical treatment.
Effect of Nano-Tracer on Identification of Sentinel Lymph Nodes in Pelvic Cavity and Postoperative Complications in Patients with Cervical Cancer
Authors: Jin Juanjuan , Liu Zhimin , Chen Yanhui
Published: November 2020

Cervical cancer is the most common malignant tumor of the female reproductive system. Its incidence rate ranks first among female malignant tumors in China and has been increasing in recent years. However, pelvic lymph node metastasis is an important factor affecting the prognosis of
cervical cancer, because pelvic lymph node metastasis determines the scope of surgery, it is also an important basis for postoperative adjuvant treatment. Therefore, an accurate and effective method is needed to detect the presence of lymphatic metastases in time to guide the need for systematic
pelvic lymph node dissection. This article explores the clinical application of nano-tracer in the surgical treatment of cervical cancer patients and the impact of postoperative complications on patients with pelvic sentinel lymph nodes. The results show that the success rate of sentinel lymph
node tracing in cervical cancer surgery is high, and it is a safe and efficient lymph tracer, which can provide an effective way to study cervical micro metastasis and lymphatic chemotherapy.
The Megacity Lagos and Three Decades of Urban Heat Island Growth
Authors: Bassett R. , Young P. J. , Blair G. S. , Samreen F. , Simm W.
Published: November 2020

Lagos, Nigeria, is rapidly urbanizing and is one of the fastest-growing cities in the world, with a population that is increasing at almost 500 000 people per year. Yet the impacts on Lagos’s local climate via its urban heat island (UHI) have not been well explored. Considering that the tropics already have year-round high temperatures and humidity, small changes are very likely to tip these regions over heat-health thresholds. Using a well-established model, but with an extended investigation of uncertainty, we explore the impact of Lagos’s recent urbanization on its UHI. Following a multiphysics evaluation, our simulations, against the background of an unusually warm period in February 2016 (during which temperatures regularly exceeded 36°C), show a 0.44°C ensemble-time-mean increase in nighttime UHI intensity between 1984 and 2016. The true scale of the impact is seen spatially as the area over which ensemble-time-mean UHIs exceed 1°C was found to increase steeply from 254 km2 in 1984 to 1572 km2 in 2016. The rate of warming within Lagos will undoubtedly have a high impact because of the size of the population (12+ million) already at risk from excess heat. Significant warming and modifications to atmospheric boundary layer heights are also found in rural areas downwind, directly caused by the city. However, there is limited long-term climate monitoring in Lagos or many similarly expanding cities, particularly in the tropics. As such, our modeling can only be an indication of this impact of urbanization, and we highlight the urgent need to deploy instrumentation.
Seasonal Precipitation Predictability for the Northern Hemisphere Using Concurrent and Preseason Atmospheric Water Vapor Transport and Sea Surface Temperature
Authors: Gao Shida , Liu Pan , Lall Upmanu
Published: November 2020

Integrated atmospheric water vapor transport (IVT) is a determinant of global precipitation. In this paper, using the CERA-20C climate reanalysis dataset, we explore three questions in Northern Hemisphere precipitation for four seasons: 1) What is the covariability between the leading spatiotemporal modes of seasonal sea surface temperature (SST), the seasonal IVT, and the seasonal precipitation for the Northern Hemisphere? 2) How well can the leading spatial modes of seasonal precipitation be reconstructed from the leading modes of IVT and SST for the same season? 3) How well can the leading modes of precipitation for the next season be predicted from the leading modes of the current season’s SST and IVT? Wavelet analyses identify covariation in the leading modes of seasonal precipitation and those of IVT and SST in the 2–8-yr band, with the highest amplitude in the March–May (MAM) season, and provide a firm physical explanation for the potential predictability. We find that a subset of the 10 leading principal components of the seasonal IVT and SST fields has significant trends in connections with seasonal precipitation modes, and provides an accurate statistical concurrent reconstruction and one-season-ahead forecast of the leading seasonal precipitation modes, thus providing a pathway to improving the understanding and prediction of precipitation extremes in the context of climate change attribution, seasonal and longer prediction, and climate change scenarios. The same-season reconstruction model can explain 76% of the variance, and the next-season forecast model can explain 58% variance of hemispheric precipitation on average.
Conceptualizing the Impact of Dust-Contaminated Infrared Radiances on Data Assimilation for Numerical Weather Prediction
Authors: Marquis Jared W. , Oyola Mayra I. , Campbell James R. , Ruston Benjamin C. , Córdoba-Jabonero Carmen , Cuevas Emilio , Lewis Jasper R. , Toth Travis D. , Zhang Jianglong
Published: November 2020

Numerical weather prediction systems depend on Hyperspectral Infrared Sounder (HIS) data, yet the impacts of dust-contaminated HIS radiances on weather forecasts has not been quantified. To determine the impact of dust aerosol on HIS radiance assimilation, we use a modified radiance assimilation system employing a one-dimensional variational assimilation system (1DVAR) developed under the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) Numerical Weather Prediction–Satellite Application Facility (NWP-SAF) project, which uses the Radiative Transfer for TOVS (RTTOV). Dust aerosol impacts on analyzed temperature and moisture fields are quantified using synthetic HIS observations from rawinsonde, Micropulse Lidar Network (MPLNET), and Aerosol Robotic Network (AERONET). Specifically, a unit dust aerosol optical depth (AOD) contamination at 550 nm can introduce larger than 2.4 and 8.6 K peak biases in analyzed temperature and dewpoint, respectively, over our test domain. We hypothesize that aerosol observations, or even possibly forecasts from aerosol predication models, may be used operationally to mitigate dust induced temperature and moisture analysis biases through forward radiative transfer modeling.
Recent Trends in Heat-Related Mortality in the United States: An Update through 2018
Authors: Sheridan Scott C. , Dixon P. Grady , Kalkstein Adam J. , Allen Michael J.
Published: November 2020

Much research has shown a general decrease in the negative health response to extreme heat events in recent decades. With a society that is growing older, and a climate that is warming, whether this trend can continue is an open question. Using eight additional years of mortality data, we extend our previous research to explore trends in heat-related mortality across the United States. For the period 1975–2018, we examined the mortality associated with extreme-heat-event days across the 107 largest metropolitan areas. Mortality response was assessed over a cumulative 10-day lag period following events that were defined using thresholds of the excess heat factor, using a distributed-lag nonlinear model. We analyzed total mortality and subsets of age and sex. Our results show that in the past decade there is heterogeneity in the trends of heat-related human mortality. The decrease in heat vulnerability continues among those 65 and older across most of the country, which may be associated with improved messaging and increased awareness. These decreases are offset in many locations by an increase in mortality among men 45–64 (+1.3 deaths per year), particularly across parts of the southern and southwestern United States. As heat-warning messaging broadly identifies the elderly as the most vulnerable group, the results here suggest that differences in risk perception may play a role. Further, an increase in the number of heat events over the past decade across the United States may have contributed to the end of a decades-long downward trend in the estimated number of heat-related fatalities.
Beyond the quantitative and qualitative divide: The salience of discourse in procedural justice policing research
Authors: Shon Phillip C , O’Connor Christopher , Cesaroni Carla
Published: November 2020

The dominant methods of studying police have involved quantitative analyses of surveys and systematic social observations of police behavior or qualitative methods such as ethnographies and interviews. The same trend applies to procedural justice research in policing. In prior works, the question of how police officers and citizens interact in situ is absent. We argue that procedural justice police research should move beyond the quantitative/qualitative distinction and consider other ways to collect and analyze data. We begin by providing a methodological critique of procedural justice research, and demonstrate the assumptions of discourse in extant works before we provide a blueprint for how to incorporate discourse analytic methods in the study of procedural justice and policing.