bluuebunny/crossref_metadata_2025 huggingface dataset:
Apigenin and Quercetin: Potential Therapeutic Challenging Effective Against in Alzheimer’s Disease
Authors: Manmohan S. Jangdey  , Anshita Gupta  , Khomendra Sarwa
Published: June 2018

Alzheimer's disease (AD) is an accelerating neurodegenerative disorder, dementia in the world. Current treatments for Alzheimer’s disease primarily focus on enhancement of cholinergic transmission & leading to neuronal dysfunction and loss in the brain. Flavonoid bioactive compounds are the major role for the designer of a new generation of therapeutic agents that are clinically effective in treating neurodegenerative diseases. Apigenin & quercetin are attractive biomarkers in this regards which has been epidemiological studies height a Neuroprotective and related to a lower risk of developing dementia or gradual decline its progressive.  The continuing investigation of the potential preventive activity of quercetin and apigenin should be evaluated in long-term exposure clinical trials, using preparations with high bioavailability and promising to yield a possible remedy for this pervasive disease. Thus, the aim of the review, we analyzed the enhancing effects of apigenin and quercetin and discuss the potential of these compounds for Alzheimer’s disease prevention and treatment.
Evaluation of Ciprofloxacin Floating-Bioadhesive Tablet Formulated with Okra Gum as Multifunctional Polymer
Authors: Alalor CA  , Uhumwangho MU  , Iwuagwu MA
Published: June 2018

Floating drug delivery systems and bioadhesive drug delivery systems are gastroretentive systems for increasing gastric residence time to obtain improved drug bioavailability. This study was to evaluate the floating and bioadhesive characteristics of Ciprofloxacin tablets formulated with Abelmoschus esculentus gum (okra gum).Okra gum was extracted and granules were prepared using the extracted Okra gum as well as sodium alginate and HPMC at concentrations of 2.5, 5 and 10 % w/w. Ciprofloxacin floating bioadhesive (CFB) tablets were evaluated for hardness, friability, in vitro buoyancy test, ex vivo bioadhesion test and drug release profiles. The floating lag time (FLT) and total floating time (TFT) for CFB tablets formulated with 10% w/w okra gum were 5.7 minutes and 8 hours respectively while the bioadhesive force was 1.324 N. Formulations of ciprofloxacin tablets containing admixtures of okra gum and sodium alginate or HPMC resulted in significant decrease (p < 0.05) in the floating lag times (≤ 3.1 minutes) and significant increase (p < 0.05) in total floating times (> 12 h). The bioadhesive force for CFB tablets containing admixtures of okra gum and sodium alginate or HPMC gave higher values in the range of 1.766 – 2.207 N. The in vitro release profiles for CFB tablets formulated with okra gum alone did not show sustained release below 10 % w/w. Batches FB10 and FB11 containing admixtures showed sustained release with maximum release of 86% at maximum time of 9 h. The dissolution profiles of tablets from batches F10 and F11 compared favourably with the profile for the commercial brand of floating ciprofloxacin tablet, MF. From the study Okra gum has shown to possess good floating and bioadhesive properties and may be utilized in the formulation gastro-retentive dosage form of ciprofloxacin which can possibly be harnessed as a targeted site-specific delivery system in the eradication of Helicobacter pylori in gastric ulcer disease as well as in the treatment of Salmonella typhi induced enteric fever.
Regeneration of Aegle marmelos (l.) Through Enhanced Axillary Branching from Cotyledenory Node
Authors: Asha Gupta  , Tessy Thomas  , Shagufta Khan
Published: June 2018

A complete protocol is standardized for invitro micropropogation of Aegle marmelos for the first time using cotyledonary nodes derived through invitro raised seedlings.Higher percentage of direct multiple shoots were regenerated from cotyledonary nodal segments through forced axillary branching.   The cotyledonary nodes of invitro raised seedlings were used as explants for shoot formation on MS Medium supplemented with Cytokinins (BAP) and Auxins (NAA), either alone or in combinations.  Maximum (80%) shoots  having shoot length of 2-3 cm were achieved on MS medium fortified with BAP (1.0 mg/l) and NAA (0.5mg/l).By repeating sub culturing of the cotyledonary node on shoot multiplication medium followed by shoot elongation medium after each harvest of the newly formed shoots. Thus, from a single cotyledonary node, about 20-25 shoots were obtained. Shoots formed in vitro were best rooted on MS medium supplemented with 1.0-2.0 mg/l Napthalene acetic acid(NAA).
Physicochemical, Phytochemical Screening and Antimicrobial Activity of Aegle marmelos
Authors: Asha Gupta  , Tessy Thomas  , Shagufta Khan
Published: June 2018

The present study was aimed to evaluate the physicochemical, phytochemical screening and antimicrobial assessment of Aegle marmelos fruits extract. The powder was evaluated for loss on drying, alcohol extractive value and aqueous extractive value. The petroleum ether, ethanol and aqueous extract were prepared by soxhlet extraction process. The phytochemical analysis of extracts was performed, and antimicrobial activity of ethanol extracts against various strains was done. The loss on drying, alcohol and aqueous extractive values were 3.9%, 14.2% and 17.6%, respectively. Phytochemical analysis showed the presence of carbohydrates, alkaloids, glycoside, flavonoids, saponins, tannins phenols in ethanol extracts. The ethanol extracts demonstrated moderate to strong antimicrobial activity against S. epidermis, S. aureus, E. coli, P. aeruginosa and C. albicans. Thus in future, extract of Aegle marmelos may be beneficial for another several species of microbes.
Plant Taxa Used in the Treatment of Diabetes in Van Province, Turkey
Authors: DALAR Abdullah
Published: June 2018

Despite
the richness of local flora and medicinal plant utilization, there is no any
report on documentation of antidiabetic botanicals used in Van province.
Therefore, the present study aimed to record accumulation of the traditional
antidiabetic medicinal plants of Van province in order to preserve the valuable
local medicines knowledge, which has been threatened by urbanization. Antidiabetic folk
medicines were determined via field surveys conducted in 1065 settlements
during the period of 2014-2017 through medicinal plants questionnaire
and structured face-to-face interviews (600 informants) with local people who
are well known in the province for their long practice in traditional medicine.
69 plant taxa (35 species with undocumented antidiabetic medicinal use in
scientific literature for Turkey) including five endemic and one rare to Turkey
belong to 16 families (principally Asteraceae and Lamiaceae) were recorded for
their traditional antidiabetic use. 52 different vernacular names were detected
which were mainly indicate morphological characteristics. Infusion prepared
from leaf and flower organs were found as the most common preparation method of
local medicines in the province. Use value analysis showed that Rheum ribes, Urtica dioica, Scutelleria orientalis
subsp. pichleri, Diplotenia
cachrydifolia, Teucrium polium, Rosa canina, Campanula glomerata subsp. hispida, Rumex scutatus, Helichrysum
plicatum subsp. plicatum and Tanacetum balsamita subsp. balsamita might serve promising
pharmaceutical agents for diabetes treatment.
Are key market players in currency derivatives markets affected by financial conditions?
Authors: Gurrib Ikhlaas
Published: June 2018

This study investigates if the biggest players in major foreign currencies futures markets are affected by current and previous financial conditions. Using root mean squared errors (RMSE), normalized RMSE, and Nash-Sutcliffe efficiency, this study compares the impact of current, 1 and 2 week lags of financial conditions onto foreign currency futures players’ net positions. The financial conditions indices used are UFCI, STLFSI, NFCI and ANFCI with weekly data set from January 2007 till December 2018. The US dollar index futures is included as a benchmark, since the financial conditions are based on US data and the most actively traded foreign currencies are paired against the USD. While RMSE and NRMSE gave mixed results into how current, 1 week and 2 weeks lagged Financial Conditions Indices (FCIs) values are related to speculators and hedgers’ net positions, lagged NFCI captured the highest correlation with both players’ net positions in Japanese Yen. 95% prediction levels encompassed the actual net positions held, including the financial crisis of 2008-2009. Forecasts were lower (higher) for hedgers (speculators) than actual net positions held during the same period. Comparatively, in the period 2016-2017, hedgers (speculators) net positions forecasts were higher (lower) than actual positions. The latter could be explained by FCIs not being affected during this period’s event, compared to net positions. While net positions data were stationary, excess kurtosis was present pointing to non-normal and autocorrelated series. This suggests the need to look into other components like non-reportable long or short positions in future analysis.
Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Focus on Mutations - Part 1
Authors: Russo Patrizia , Lococo Filippo , Kisialiou Aliaksei , Prinzi Giulia , Lamonaca Palma , Cardaci Vittorio , Tomino Carlo , Fini Massimo
Published: June 2018

Background:

We report a comprehensive overview of current Chronic Obstructive
Lung Disease (COPD) therapies and discuss the development of possible new pharmacological
approaches based on “new” knowledge. Specifically, sensitivity/resistance to corticosteroids
is evaluated with a special focus on the role of gene mutations in drug response.

Objective:

Critically review the opportunities and the challenges occurring in the treatment of
COPD.

Conclusion:

Findings from “omics” trials should be used to learn more about biological targeted
drugs, and to select more specific drugs matching patient’s distinctive molecular profile.
Specific markers of inflammation such as the percentage of eosinophils are important in
determining sensitivity/resistance to corticosteroids. Specific gene variations (Single nucleotide
polymorphisms: SNPs) may influence drug sensitivity or resistance. Clinicians working
in a real-world need to have a suitable interpretation of molecular results together with a
guideline for the treatment and recommendations. Far more translational research is required
before new results from omics techniques can be applied in personalized medicine in realworld
settings.
The Efficacy of Omega-3 Supplement on Prevention of Retinopathy of Prematurity in Premature Infants: A Randomized Double-blinded Controlled trial
Authors: Khalesi Nasrin , Bordbar Arash , Khosravi Nastaran , Kabirian Morteza , Karimi Alireza
Published: June 2018

Background:

The present study aimed to assess the efficacy of omega-3 in treating ROP in premature
infants.

Methods:

This randomized double-blinded controlled trial was performed on 160 premature infants with gestational
age lower than 32 weeks and birth weight < 1500 grams who were at risk of ROP development (Tehran,
Iran-2013). Children were randomly assigned to two groups. The intervention group received 300 mg omega-3
daily and the control group received sterile water as the placebo. The severity of ROP was defined according to
the International Classification of ROP.

Results:

The frequency of ROP was 7.5% in the group received omega-3 and 20.0% in the placebo group with a
significant difference (p = 0.021). Regarding the severity of ROP in the intervention group, ROP grade I was
found in two patients and ROP grade II in four patients; while ROP grade I, II, and III were revealed in 6, 6, and 4
patients in placebo group indicating a significant difference between the two groups (p = 0.001). Using the multivariate
logistic regression modeling with the presence of gender, gestational age, and birth weight, the use of
omega-3 was associated with reduced risk for ROP (p = 0.045).

Conclusion:

The use of omega-3 supplement can be an appropriate treatment option for the treatment of ROP in
premature infants.
An Integrated Multi-Label Classifier with Chemical-Chemical Interactions for Prediction of Chemical Toxicity Effects
Authors: Liu Tao , Chen Lei , Pan Xiaoyong
Published: June 2018

Aims and Objective: Chemical toxicity effect is one of the major reasons for declining
candidate drugs. Detecting the toxicity effects of all chemicals can accelerate the procedures of drug
discovery. However, it is time-consuming and expensive to identify the toxicity effects of a given
chemical through traditional experiments. Designing quick, reliable and non-animal-involved
computational methods is an alternative way.

Method:

In this study, a novel integrated multi-label classifier was proposed. First, based on five types
of chemical-chemical interactions retrieved from STITCH, each of which is derived from one aspect of
chemicals, five individual classifiers were built. Then, several integrated classifiers were built by
integrating some or all individual classifiers.

Result and Conclusion:

By testing the integrated classifiers on a dataset with chemicals and their
toxicity effects in Accelrys Toxicity database and non-toxic chemicals with their performance evaluated
by jackknife test, an optimal integrated classifier was selected as the proposed classifier, which
provided quite high prediction accuracies and wide applications.
Oscillatory Dynamics of P53 Network With Time Delays
Authors: Wang Conghua , Yan Fang , Zhang Yuan , Liu Haihong , Zhang Linghai
Published: June 2018

Aims and Objective: A large number of experimental evidences report that the oscillatory
dynamics of p53 would regulate the cell fate decisions. Moreover, multiple time delays are
ubiquitous in gene expression which have been demonstrated to lead to important consequences on
dynamics of genetic networks. Although delay-driven sustained oscillation in p53-based networks is
commonplace, the precise roles of such delays during the processes are not completely known.

Method:

Herein, an integrated model with five basic components and two time delays for the
network is developed. Using such time delays as the bifurcation parameter, the existence of Hopf
bifurcation is given by analyzing the relevant characteristic equations. Moreover, the effects of such
time delays are studied and the expression levels of the main components of the system are
compared when taking different parameters and time delays.

Result and Conclusion:

The above theoretical results indicated that the transcriptional and
translational delays can induce oscillation by undergoing a super-critical Hopf bifurcation. More
interestingly, the length of these delays can control the amplitude and period of the oscillation.
Furthermore, a certain range of model parameter values is essential for oscillation. Finally, we
illustrated the main results in detail through numerical simulations.
A Structural Perspective on the Modulation of Protein-Protein Interactions with Small Molecules
Authors: Demirel Habibe Cansu , Dogan Tunca , Tuncbag Nurcan
Published: June 2018

Protein-Protein Interactions (PPIs) are the key components in many cellular processes including
signaling pathways, enzymatic reactions and epigenetic regulation. Abnormal interactions of some
proteins may be pathogenic and cause various disorders including cancer and neurodegenerative diseases.
Although inhibiting PPIs with small molecules is a challenging task, it gained an increasing interest
because of its strong potential for drug discovery and design. The knowledge of the interface as well
as the structural and chemical characteristics of the PPIs and their roles in the cellular pathways is necessary
for a rational design of small molecules to modulate PPIs. In this study, we review the recent progress
in the field and detail the physicochemical properties of PPIs including binding hot spots with a
focus on structural methods. Then, we review recent approaches for structural prediction of PPIs. Finally,
we revisit the concept of targeting PPIs from a systems biology perspective and we refer to approaches
that are usually employed when the structural information is not present.
Immediate Postoperative Portable Radiograph After Total Knee Replacements: A Necessity or a Burden?
Authors: Aljawder Abdulla , Alomran Dana , Alayyoub Mohammed , Alkhalifa Fahad
Published: June 2018

Background:

Total Knee Replacement (TKR) is one of the most commonly performed orthopaedic surgery(1). Immediate postoperative portable radiographs are performed after primary TKR in order to identify any potential complications and technical flaws. It also serves as a reference for comparison with subsequent radiographs. The aim of this study was to evaluate the clinical and economical value of these radiographs in TKR. It compares the quality of the portable radiograph, taken immediately post-operation, with in-suite radiographs taken 5-7 weeks post-operation

Methods:

In this retrospective study, a consecutive series of 389 TKR patients from January-2011 to March-2015 were reviewed. Radiological evaluation consisted of assessing the beam angle and the exposure on the images. Implant positioning was also compared by measuring the anatomical axis to look for component alignment discrepancies.

Results:

The quality of the portable recovery room radiograph was overall inferior to the radiology suite radiograph regarding both beam angle and exposure. Component alignment discrepancies were also identified in the angle measurements between both types of radiographs.

Conclusion:

Therefore, our study demonstrated that there is no clinical or financial value obtained from postoperative portable radiograph. Furthermore, Immediate recovery room radiographs should be avoided from being performed routinely and may only be used in cases where the surgeon is utilizing a new implant or technique. No external funding was provided for this study from any source.
Clinical and Hematological Profiles of Malaysian Ponies Experimentally Infected with a Field Strain of Trypanosoma evansi
Authors: Elshafie E.I. , Sani R.A. , Sharma R. , Abubakar I.A.
Published: June 2018

Background:

No outbreak has been reported on Trypanosoma evansi infection in Malaysia ponies since 1983, and little is known about the interaction between T. evansi and ponies in the country. Therefore, an experimental study was designed to evaluate the pathogenicity of a local strain of T. evansi in the local ponies.

Method:

For this purpose, four healthy local ponies were inoculated with 102 live trypanosomes/kg body weight, whereas two ponies served as negative control. Blood samples and rectal temperature were collected on alternate days from both groups for 54 days. Physical examination comprised visible mucous membrane and any appearance of clinical signs were observed daily. The number of trypanosomes was estimated using the Neubauer haemocytometer method. Complete haemogram measurements were performed immediately using an automated blood cell counter and the data obtained was evaluated using the general linear model as linear regression. All infected ponies were salvaged treated with 7 mg/kg of diminazene diaceturate.

Results:

The four infected ponies developed parasitaemia on the 4th day post-infection (DPI), whereas the first high mean of parasites count was recorded on the 8th DPI. Parasitaemia was detected at a level that fluctuated throughout the infection period (30 days) in all infected ponies with a mean of 13.5x106 trypanosomes/ml blood on the 30th DPI. Successive peaks of pyrexia were accompanied by the peaks of parasitaemia and the highest temperature (39.4°C) was observed on the 20th DPI. Excessive weakness and a reduction of appetite fluctuated in the infected ponies during the infection and one animal died unexpectedly on the 23rd DPI. The mean values for RBC, PCV, Hb and thrombocyte count were significantly lower in the infected ponies than the control groups. Neutrophil and eosinophil were significantly declined after the onset of parasitaemia, whereas monocyte increased significantly in the infected group.

Conclusion:

The appearance of clinical signs and changes in haematological parameters suggests that Malaysian local ponies are susceptible to T. evansi infection. Treatment of the infected ponies with the recommended dosage of diminazene diaceturate was successful in the surviving ponies.
Post-exercise Glucose Response Following Whey Protein Ingestion in Healthy Young People: A Randomized Pilot Study
Authors: Kluess Heidi A. , Neidert Leslie E.
Published: June 2018

Background:

Whey protein may have an effect directly on the muscle to affect exercise glucose response.

Objective:

The study aimed to measure post-exercise glucose recovery with supplementation and the role of DPP-IV and IL-6.

Methods:

Twenty-four participants were randomly assigned to one of three supplementation conditions (CTL: water, WPI: 31g whey protein isolate, and CHO: 32g fructose beverage; WPI and CHO beverages were isocaloric). During the Baseline Visit, participants performed an Oral Glucose Tolerance Test (OGTT) with no exercise or supplementation. On their second and third visits, participants consumed their assigned beverage then completed a maximal treadmill protocol until volitional fatigue. An OGTT was completed on the second visit, and blood samples were collected via venipuncture on the third visit for IL-6, Insulin and DPP-IV.

Results:

Glucose delta peak was attenuated in WPI+exercise by -45±25% and CHO+exercise by -49±21%, compared to baseline (p<0.05). Glucose area under the curve was only attenuated with WPI+exercise (5,993±1,013mg/dl*min), compared to baseline (10,604±4,589mg/dl*min; p<0.05). Insulin was elevated in the WPI+exercise (111±57pmol/L) and CHO+exercise (119±70pmol/L), compared to rest (WPI: 61±40pmol/L; CHO: 78±56pmol/L; p<0.05). IL-6 and DPP-IV activated T-cells (CD26+) were not different among groups. However, plasma DPP-IV was higher in WPI (8±6U/L) compared to CTL (0.7±2U/L) and CHO (0.6±4U/L; p<0.05).

Conclusion:

We found that a single dose of whey protein given prior to exercise results in elevated DPP-IV activity in the plasma and improved glucose response. Together these data suggest that whey protein as a supplement to exercise may be beneficial for humans trying to manage their blood sugar.
Assessing the Perceptions of Inspiratory Muscle Training in Children With Cystic Fibrosis and Their Multidisciplinary Team: Mixed-Methods Study (Preprint)
Authors: McCreery Jessica L , Mackintosh Kelly A , Cox Narelle S , McNarry Melitta A
Published: June 2018

BACKGROUND

Little is known about the opinions or perceived benefits of an inspiratory muscle training intervention in patients with cystic fibrosis and their multidisciplinary team.

OBJECTIVE

The aim of this qualitative study was to examine patients' and multidisciplinary teams' views on inspiratory muscle training to inform and tailor future interventions.

METHODS

Individual, semistructured interviews were conducted to evaluate participants’ perspectives of a 4-week inspiratory muscle training intervention. In this study, 8 of 13 individuals involved in the inspiratory muscle training program (5 children aged 11-14 years; 2 physiotherapists; and 1 respiratory physician) participated. Interviews were transcribed verbatim, analyzed using thematic analyses, and then coded into relevant themes.

RESULTS

Four key themes emerged: acceptability, facilitators, barriers, and recommendations. While fun, enjoyment, and improved perceived physical ability were reported by children and their multidisciplinary team following the inspiratory muscle training program, the multidisciplinary team identified factors such as time and cost as key barriers.

CONCLUSIONS

A short inspiratory muscle training program was perceived to have positive effects on the physical ability and psychosocial health of children with cystic fibrosis. These findings highlight the importance of obtaining participants’ and multidisciplinary teams' perceptions and recommendations to ensure the efficacy and optimal design of future inspiratory muscle training protocols.
Variaciones en la realización de la estructura argumental preferida en niños y adultos a partir de la narración de anécdotas personales y cuentos en imágenes
Authors: Castillo Hernández Carolina , Belloro Valeria A. , Alarcón Neve Luisa Josefina
Published: June 2018

En este trabajo se exponen los resultados del análisis de narrativas de adultos y de niños bajo la perspectiva de la estructura argumental preferida (EAP; Du Bois, 1987). El corpus se conformó con base en dos tareas de elicitación: la narración de un cuento a partir de imágenes y la narración de una anécdota personal. Los resultados muestran que las tendencias de la EAP son similares en niños y adultos, pero con cambios significativos entre las dos tareas de elicitación. En particular, un segundo análisis de los datos muestra una preferencia relativa, en la tarea del cuento, por la codificación léxica de tópicos continuos, lo que sugiere que los hablantes (y particularmente los niños) combinan, para esta tarea específica, estrategias narrativas con estrategias de descripción de imágenes independientes.
Habilidades de percepción fónica en español / L2 y su relación con el nivel de dominio lingüístico
Authors: Blanco Canales Ana
Published: June 2018

La adquisición del componente fónico de una lengua extranjera implica el desarrollo tanto de nuevas habilidades de producción como de complejas estrategias de percepción. Se asume que tal desarrollo se da de forma paralela, dado que son actividades complementarias, dependientes la una de la otra. Con objeto de medir las habilidades perceptivas de un grupo amplio de estudiantes de español, analizar qué cuestiones fonéticas les suponen más dificultad y determinar el impacto del nivel de dominio lingüístico sobre la percepción, se aplicó un test a 204 alumnos de español / L2 de diez lenguas maternas diferentes, cuyos niveles de conocimiento de español se sitúan entre el A2 y el C1 (según el MCER). Las 61 200 respuestas obtenidas se han analizado estadísticamente. Los datos muestran que los comportamientos perceptivos de los participantes son notablemente homogéneos, sin que se aprecien diferencias significativas en función del dominio lingüístico del hablante, lo que nos lleva a concluir que el desarrollo de las habilidades de percepción en español / L2 sigue un patrón temporal diferente al de producción.
Interpretación social y multiculturalidad: el caso de las lenguas indígenas de México
Authors: Iglesias Ximena , Reyes Antonio
Published: June 2018

La interpretación social se entiende como un proceso de mediación en el que la comunicación sucede en un plano social que implica la interacción de grupos culturalmente diferentes, tales como migrantes, refugiados o comunidades indígenas (Pöchhacker, 2004; Hale, 2007). En este marco, el objetivo de este trabajo es exponer el escenario general que supone la interpretación social en México dada la gran diversidad lingüística que caracteriza a este país. Así, se enfatiza la problemática que debe resolver el intérprete social en tanto que se enfrenta a diferentes lenguas y diferentes culturas que coexisten en una realidad aparentemente homogénea. Finalmente, se muestran los avances y resultados que diversas instituciones públicas y privadas han hecho en torno a este fenómeno.
La interpretación de textos en los comienzos de la alfabetización del niño sordo
Authors: Zamudio Mesa Celia , Ortiz Sánchez Rodrigo
Published: June 2018

El objetivo del estudio es indagar si los niños sordos que están aprendiendo a leer siguen una evolución semejante a la de la lectura prealfabética de los oyentes, según los datos de la investigación psicogenética de la escritura (Ferreiro & Teberosky, 1979). La situación experimental involucró la interpretación en lengua de señas mexicana (LSM) de enunciados escritos en español: los niños recibían del entrevistador la lectura de los enunciados; después debían decidir qué estaba escrito y señalar la parte de texto donde pensaban que se encontraba. Participaron 22 niños sordos profundos (15 hombres y 7 mujeres con un rango de edad entre 6 y 9 años) de una escuela primaria privada de la Ciudad de México especializada en la enseñanza de LSM. Los resultados muestran cómo la reconstrucción de lo escrito que realizan los niños sordos es también un proceso evolutivo, aunque con diferencias importantes respecto de los oyentes, debidas principalmente a la estructura de las lenguas involucradas. El estudio discute tales discrepancias y aporta datos que permiten reflexionar sobre las maneras como se alfabetiza a los sordos.
[T]errores cotidianos. Hipérbole, caricatura, deformación y otros catalizadores de la invención
Authors: Lus Arana Luis Miguel
Published: June 2018

Pese a su tradicional codificación como disciplina menor, o degeneración de expresiones artísticas verdaderas, la caricatura ha gozado de una especial atención por parte de los artistas, así como de una reivindicación por parte de la moderna historia del arte. Ernst Hans Josef Gombrich, siguiendo los pasos de Ernst Kris y de historiadores anteriores, encontró en la caricatura el ejemplo paradigmático de la prevalencia del reconocimiento frente al parecido en la representación. Pero además, en lo que tiene de deformación de la realidad, la caricatura tiene una poderosa capacidad de catalizador creativo, cuyo interés para la arquitectura está aún por explorar.
FuckUp Nights. La exhibición del fracaso
Authors: Barroso Olmedo Erandi Paula
Published: June 2018

hace aproximadamente cinco años, me pareció extrañísimo recibir una invitación para asistir a una sesión destinada a exponer el fracaso profesional de otros. Alrededor de 12 personas nos reunimos, en el patio trasero de una antigua casa de la colonia Roma, con el objetivo de escuchar cómo, paso a paso, y a pesar de todos los esfuerzos por evitarlo, las cosas salieron mal. La valentía, acompañada de cierto grado de vergüenza, de los tres presentadores y la presencia de algunos espectadores fueron suficientes para iniciar las FuckUp Nights, una serie de eventos destinados a compartir historias
de fracasos profesionales.
The Price of Formal Freedom
Authors: Delgado Velasco Marcela
Published: June 2018

In the world of mechanization, the true copy is cast as the virtuous hero and the variant as the villain. The variant is swiftly identified on the production line, seized and eliminated; it is to be avoided at all costs. In the new digital world of continuous differentiation, in which variation reigns supreme, where does the margin for error lie? Liberated from the pressures of standardization, are we suddenly error-free and carefree?
Ciudad neoliberal y políticas de la imagen
Authors: Montes Ruiz Ana Paula
Published: June 2018

A propósito del proyecto de investigación que desarrollo dentro del Programa de Doctorado de Urbanismo de la unam, el presente artículo propone construir un objeto de estudio que, si bien inscrito en el campo del urbanismo, pueda ser confrontado desde la perspectiva de los estudios de la imagen. Propongo que el avance de la urbanización no puede ser comprendida sólo en el registro político económico que ofrecen la geografía crítica, porque para comprender un tipo de procedimiento de naturaleza visual –comunicacional y estético– afectiva que ha sido incorporado dentro del proceso neoliberal de producción del espacio es pertinente incorporar la dimensión biopolítica.
Notas para una mirada geopolítica a la representación del espacio y los espacios de representación: 3 ejes argumentativos de aproximación
Authors: González Luna Fabián
Published: June 2018

En el artículo se desarrolla una reflexión desde el espacio como clave epistemológica que busca articular una mirada geopolítica a los fenómenos de las rentas de segregación y cultural, por un lado, y a la justicia espacial por el otro. En específico se ponen en discusión tres tesis o ejes argumentativos, el primero refiere a la geopolítica como una estrategia metodológica que permite considerar a las representaciones espaciales como subjetivaciones dominantes fundamentales en el desarrollo geográfico desigual. El segundo aborda cómo la producción de representaciones espaciales permite producir rentas de segregación y culturales verticalizadas. Por último, se discuten los espacios de representación como posibilidad de justicia espacial.
El trazo sutil amplificado: dibujos de observación en Taller de Arquitectura
Authors: Cañete Islas Omar
Published: June 2018

Se pretende sistematizar una serie de experiencias docentes que buscan acotar un campo comprensivo respecto del dibujo de observación arquitectural, usualmente conocido como croquis. En un sentido más teórico-pedagógico, se pretende que los alumnos puedan explorar y transitar de modo sensitivo, pero graduado y continuo, entre dos planos: a) la expresión subjetiva y b) la composición formal donde el trazo tiende a abstraer y objetivar y, por ende, organizar y disponer geométricamente lo observado en función de un orden relacional. Pese a sus diferencias (subjetivo vs. objetivo), ambos planos los asumiremos desde un orden generativo, dinámico y complejo.
Open and transparent research practices and public perceptions of the trustworthiness of agricultural biotechnology organizations
Authors: Landrum Asheley R. , Hilgard Joseph , Lull Robert B. , Akin Heather , Hall Jamieson Kathleen
Published: June 2018

Public trust in agricultural biotechnology organizations that produce so-called ‘genetically-modified organisms’ (GMOs) is affected by misinformed attacks on GM technology and worry that producers' concern for profits overrides concern for the public good. In an experiment, we found that reporting that the industry engages in open and transparent research practices increased the perceived trustworthiness of university and corporate organizations involved with GMOs. Universities were considered more trustworthy than corporations overall, supporting prior findings in other technology domains. The results suggest that commitment to, and communication of, open and transparent research practices should be part of the process of implementing agricultural biotechnologies.
Defesas de Mestrado - Turma 2016 do MPGEC - ESPM Rio
Authors: Dubeux Veranise
Published: June 2018

Resumo das defesas
Higienismo e ações de remodelamento urbano no Recife (1900-1929)
Authors: Neves Marcos Alessandro
Published: June 2018

Recife no início do século XX, assim como outras capitais do Brasil, enfrentou diversas mudanças em seu aspecto paisagístico, demolição de casarões antigos, remoção de populações carentes de áreas habitadas há vários anos para dar lugar a empreendimentos imobiliários com a proposta de modernização e embelezamento da cidade. Dessa forma, o presente artigo tem como intuito analisar como o discurso modernizante foi utilizado com o intuito de promover obras de viés higienistas, que almejavam a exclusão da população que ocupava esses espaços, atendendo aos anseios de uma elite local que clamava por uma cidade tida como moderna para os seus conceitos.
Motivation for occupation and socio-demographic characteristics of students - future preschool teachers
Authors: Dubljanin Sasa , Maksimovic Aleksandra
Published: June 2018

Researching the motivation of students - future preschool teachers for their
professional choice is important for several reasons. Relevant studies
indicate that the motivation of students who have an interest for teaching
is one of the most important determinants of the quality of their work and
that is closely related to their later dedication to vocation and
professionalism. The aim of this research was to examine the relationship
between the motivation of students, future preschool teachers, for this
occupation and their socio-demographic characteristics. We investigated the
most important reasons that guided students in choosing a future occupation,
whether they had previous experience in working with children and whether
the selected studies were their first choice. Also, it was examined whether
there are statistically significant differences among students in the
motivation for a future call with respect to certain socio-demographic
characteristics. The research involved 241 students of the first year, of
which 130 students of the Faculty of Applied Studies for Preschool Teachers
in Sabac and 111 students of the Faculty of Teacher Training in Belgrade,
the study course for preschool teachers. The obtained results show that
students who completed secondary medical school had more experience in
working with children than respondents who attended another secondary
school. It was also noticed that the largest number of students in the cause
think that the working time of the educator is appropriate, while the
smallest number of respondents agree with the perception of preschool
teacher occupation as ?permanent?. The paper also concludes that a detailed
introduction of socio-demographic and personal characteristics that
influenced the choice of the vocation can be a significant support for the
creation of programmes of initial education of preschool teachers.
The arithmetic of gestalt
Authors: VandenBerg Stephanie D.
Published: June 2018

It has been said that we are the sum of all we have met. As a learner in the
emergency department, I have a lot of meeting to do. Take Sandy, a 35-year-old
single mother.

Her triage note reads that she came to the hospital after losing her breath
bathing her 3-year-old daughter.

If you had read it.

If you had asked her, she would have told you that she’s been sweating
through her clothing during the day, causing her colleagues in the university
administrative office to stare awkwardly. She says no to your list of Pulmonary
Embolism Rule-Out Criteria (PERC) criteria queries, uses a copper intrauterine
device (IUD) as birth control (it was the cheapest option), and is healthy, as far
as she knows.

If you had asked her.

If you had listened, she would have described a difficult social situation
that had left her the sole provider for her young daughter. She walks the local
drag once or twice a month, selling sex to whomever will buy as her current job
does not pay enough to make rent every 30 days.
Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway
Authors: Huang Chao , Fisher Kiera P. , Hammer Sandra S. , Navitskaya Svetlana , Blanchard Gary J. , Busik Julia V.
Published: June 2018

Diabetic retinopathy (DR) is a microvascular complication of diabetes and is the leading cause of vision loss in working-age adults. Recent studies have implicated the complement system as a player in the development of vascular damage and progression of DR. However, the role and activation of the complement system in DR are not well understood. Exosomes, small vesicles that are secreted into the extracellular environment, have a cargo of complement proteins in plasma, suggesting that they can participate in causing the vascular damage associated with DR. We demonstrate that IgG-laden exosomes in plasma activate the classical complement pathway and that the quantity of these exosomes is increased in diabetes. Moreover, we show that a lack of IgG in exosomes in diabetic mice results in a reduction in retinal vascular damage. The results of this study demonstrate that complement activation by IgG-laden plasma exosomes could contribute to the development of DR.
ADRF Network Hosts Research Conference to Advance Uses of Administrative Data in the United States
Authors: King Monica M
Published: June 2018

The Administrative Data Research Facilities (ADRF) Network is a new U.S.-based effort aimed at advancing the uses of administrative data in social science research. Together with Georgetown University’s Massive Data Institute, the ADRF Network hosted its first conference in November 2017 to share approaches and build collaborative opportunities. The conference illustrated the importance of private sector data, the need for data intermediaries, and the essential process of building trust in moving forward this emerging field in the United States.
PEMAKNAAN LOYALITAS KARYAWAN PADA GENERASI X DAN GENERASI Y (Studi Pada Karyawan Di Indonesia)
Authors: Nindyati Ayu Dwi
Published: June 2018

Beberapa survey menjelaskan tidak kurang dari 30% angkatan kerja saat ini adalah generasi Y (gen Y) dengan segala karakteristik yang ada. Perusahaan saat ini didominasi kombinasi antara generasi X (gen X) dan gen Y, yang masing-masing generasi memiliki karakteristik yang berbeda. Lingkungan dan perkembangan teknologi di tempat bekerja para gen X dan gen Y membentuk karakteristik yang berbeda. Dalam dunia Industri, salah satu yang menjadi perbincangan adalah loyalitas karyawan yang dipahami sebagai keyakinan karyawan atas pilihannya dalam mendukung kesuksesan organisasi tempatnya bekerja. Secara singkat karyawan yang loyal memberikan indikator perilaku bersedia untuk menetap dalam organsasi tempatnya bekerja. Penelitian ini bertujuan untuk menggali pemaknaan akan loyalitas pada gen X dan gen Y, dengan harapan dapat membantu manajemen untuk mengelola karyawannya. Penelitian dilakukan dengan metode survey pada 108 karyawan gen Y (L = 42 dan P = 66) dan 88 karyawan gen X (L = 33 dan P = 55) di beberapa kota besar di Indonesia (Jakarta, Bandung, Yogyakarta, Semarang, Denpasar, Solo, Manado dan Surabaya). Rata-rata usia gen Y adalah 29 tahun dan gen X adalah 43 tahun. Hasil utama penelitian ini menjelaskan bahwa baik gen X dan gen Y memiliki perbedaan yang signifikan tentang tingkat kepentingan loyalitas karyawan. Gen X menyatakan bahwa loyalitas lebih penting dibandingkan pada gen Y (Mean gen X = 4 dan Mean gen Y = 3,77). Secara frekwensi pindah bekerja memang gen Y memiliki pengalaman pindah kerja yang lebih besar dibandingkan gen X. Pada gen Y loyalitas lebih dipandang pada bagaimana karyawan komit dan bertanggung jawab secara profesionalitas terhadap tugasnya dengan dilandasi kompetensi yang tepat. Gen X memandang loyalitas berkaitan dengan bagaimana karyawan menjalankan fungsinya yang berorientasi pada kemajuan organisasi atau pencapaian tujuan organisasi.  Artinya bahwa pada gen Y lebih focus pada pengembangan karir dalam dirinya sedangkan dalam gen X ketika berorientasi pada pengembangan karir adalah mengarah kepada pengembangan organisasinya. Kata kunci: Gen X, Gen Y, Pemaknaan (meaning), Loyalitas
PEKERJAAN SOSIAL DALAM SETTING KEBENCANAAN
Authors: - Tukino -
Published: June 2018

Profesi pekerjaan sosial memiliki peranpenting dalam penanggulangan bencanabaik pada saat pra bencana, tanggapdarurat maupun pasca bencana. Padasaat pra bencana, kontribusi pekerjaansosial berfokus pada upaya penguranganrisiko bencana, antara lain melaluikegiatan; peningkatan kesiapsiagaanmasyarakat dan mitigasi dalammenghadapi kemungkinan terjadinyabencana, pemetaan kapasitasmasyarakat, dan melakukan advokasi keberbagai pihak terkait kebijakanpenanggulangan bencana. Pada saattanggap darurat, pekerjaan sosialmembantu pemulihan kondisi fisik danpenanganan psikososial dasar bagi korbanbencana. Pada saat pasca bencana,pekerjaan sosial melakukan upayapemulihan kondisi psikologis korbanbencana, khususnya mengatasi traumadan pemulihan kondisi sosial, sertapengembangan kemandirian korbanbencana.
Tantangan Pekerjaan Sosial di Masa Depan dalam kaitannya dengan Era Marketing 3.0 dan CSR 2.0
Authors: Wibowo Hery -
Published: June 2018

Berbagai analisis pemasaran mengatakan bahwa saat ini dunia memasuki era Marketing3.0, dimana dunia industri sudah harus memandang individu (konsumen) dianggapsebagai mahluk yang bukan rasional dan emosional, namun juga memiliki kebutuhan danrasa spiritual. Artinya, dibutuhkan sebuah cetak biru baru bagi pemikiran terkait strategipertumbuhan perusahaan. Dengan bahasa yang lain, dapat dikatakan bahwaPerkembangan ini, ternyata selaras dengan perkembangan CSR, yang semakin tidakbersifat charitas semata, namun semakin tergabung dengan grand strategy perusahaan.Kemajuan tersebut, dikenal dengan nama Corporate Social Responsibility 2.0, yaitusebuah semangat untuk memperbaiki segela kekurangan dari strategi CSR sebelumnya.Mengamati perkembangan tersebut, maka sangat perlu kiranya bagi praktisi pekerjaansosial untuk tetap berperan serta aktif dalam perkembangan pemikiran dunia ini. Hal inimengingat bahwa ranah pekerjaan sosial, terutama pekerjaan sosial industri sangat dekatdengan isu perkembangan marketing 3.0 dan CSR 2.0 yang memang berpotensimengubah wajah dunia industri kedepan
KEHIDUPAN SUKU LAUT DI BATAM: SEBUAH FENOMENA KEBIJAKAN PEMBANGUNAN DI PULAU BERTAM KOTA BATAM
Authors: Rahmawati Atik
Published: June 2018

Suku Laut (Sea Nomads) merupakan salah komunitas pribumi (indigenous people) yang mendiami wilayah perairan Kepulauan Riau dengan jumlah terbanyak berdasarkan pendataan Departemen Sosial (Depsos) RI 1988, sekitar 11,23% terkonsentrasi berada di wilayah perairan Batam, berada di sekitar Selat Malaka, Selat Philip, dan Laut Cina Selatan. Disebut sebagai Sea Nomads karena keberadaannya yang hidup nomaden dengan melakukan seluruh aktifitas kegiatan hidup tinggal di sebuah perahu atau sampan yang beratapkan sebuah Kajang. Hidup nomaden di Laut tentu saja mempunyai resiko hidup yang sewaktu-waktu dapat mengancam jiwa jika tiba-tiba cuaca buruk datang, disamping kurang keterjangkauan akan pelayanan sosial yang harusnya mereka dapatkan sebagai warga negara diantaranya pendidikan, kesehatan, perumahan. Hal ini juga mengingat bahwa sejak tahun 1973 Batam sebagai wilayah strategis daerah perbatasan negara tumbuh menjadi daerah Industri, perdagangan, galangan kapal, dan pariwisata yang mempunyai otoritas pengembangan wilayah. Pesatnya pembangunan di Batam tentu saja membawa pengaruh terhadap kehidupan Suku Laut, tak terkecuali dengan program pembangunan oleh Depsos RI terutama sejak tahun 1989 dengan penempatan mereka pada permukiman yang juga melibatkan unsur masyarakat setempat dalam hal ini Orsos Forum Komunikasi dan Konsultasi Sosial (FKKS) Batam yang berada di pulau Bertam-Kota Batam. Tulisan ini berusaha menggambarkan kehidupan Suku Laut yang telah mengalami perubahan hidup menetap yang berada di pulau Bertam-Kota Batam dengan menyajikan impact yang diakibatkan oleh adanya kebijakan pembangunan.
PEMBERDAYAAN EKONOMI LOKAL MELALUI PELATIHAN PERENCANAAN BISNIS UNTUK WIRAUSAHA PEMULA
Authors: Resnawaty Risna , Apsari Nurliana Cipta , Wibhawa Budhi , Humaedi Sahadi
Published: June 2018

Pembangunan masyarakat saat ini berlandaskan paradigma bottom up, sebuah pemahaman pembangunan yang tidak hanya berangkat dari bawah, namun paradigma ini juga memiliki arti bahwa masyarakatlah yang mengendalikan pembangunan. Dalam kegiatan PKM ini, tim berusaha mengajak masyarakat untuk dapat mengenali, memahami kondisi-kondisi aktual dalam masyarakat; dan merumuskan kegiatan-kegiatan yang sesuai dengan kebutuhan masyarakat. Kegiatan PKM yang diawali dengan proses assessment bertujuan untuk meningkatkan kesadaran masyarakat akan potensi ekonomi lokal yang ada di lingkungan masyarakat, sehingga dapat memanfaatkan potensi tersebut secara maksimal, selain itu dengan adanya PKM ini juga, kapasitas masyarakat dapat ditingkatkan terutama pengetahuan dan pemahaman mengenai wirausaha kepada masyarakat.Berdasarkan hasil pemetaan/assessment diketahui bahwa Desa Sukarasa tidak hanya memiliki potensi alam yang melimpah, namun didukung pula oleh sumber daya manusia yang terampil terutama dalam kerajinan tangan dan olahan makanan. Walaupun demikian kondisi kehidupan masyarakat, terutama pada aspek ekonomi belumlah memadai, hal ini disebabkan oleh beberapa faktor seperti kondisi kualitas SDM yang masih rendah dan infrastruktur desa yang juga belum memadai. Sebagai contoh masyarakat pelaku industri kerajinan tangan dan olahan makanan belum mampu untuk menghasilkan produk yang ‘berbeda’ dan berkualitas bagus sehingga memiliki nilai jual tinggi. Dengan pertimbangan dari berbagai kondisi tersebut, maka kegiatan PKM ini diarahkan pada aspek ekonomi dengan menyelenggarakan pelatihan yang bertemakan “Pemberdayaan Ekonomi Lokal Melalui Pelatihan Perencanaan Bisnis Untuk Wirausaha Pemula”.Hasil dari kegiatan pelatihan tersebut, nampak bahwa warga lebih termotivasi untuk melakukan kegiatan wirausaha, sebab masyarakat sudah memahami mengenai strategi usaha terutama mengenai pemasaran, dan masyarakat berharap kegiatan serupa dapat dilakukan kembali di Desa Sukarasa.