bluuebunny/crossref_metadata_2025 huggingface dataset:
Propiedades y opciones para valorizar el lactosuero de la quesería artesanal
Authors: Mazorra-Manzano Miguel Ángel , Moreno-Hernández Jesús Martín
Published: February 2020

El lactosuero posee una gran cantidad de los componentes de la leche, sin embargo, una alta proporción del volumen generado se sigue tirando, provocando pérdida de nutrientes y problemas de contaminación. El objetivo del presente trabajo fue proveer información sobre las propiedades nutricionales, funcionales y biológicas del lactosuero, generado por la industria quesera artesanal, así como evidencias científicas recientes que sustentan, bajo distintos enfoques tecnológicos, el potencial de aprovechamiento, mediante su transformación o recuperación para adicionarle valor. Las oportunidades en la valorización del lactosuero, a través de la elaboración de diversos productos lácteos, como el requesón (queso de suero), bebidas fermentadas o con frutas, bebidas para deportistas, bebidas alcohólicas, mantequilla de suero, dulces, helados y paletas, reflejan el nicho de oportunidades para hacer la industria quesera artesanal más redituable. El cambio de paradigmas en los productores artesanales, en percibir al lactosuero como una fuente de co-productos para su recuperación, transformación y reincorporación a sus procesos, acorde a las capacidades tecnológicas de dicha industria, y no como un subproducto, reduciría las pérdidas de componentes de alto valor (e.g., proteína, lípidos y azúcares), trayendo consigo efectos benéficos, tanto ambientales como económicos.
Cinética de la adsorción de fluoruro y arsénico usando nano-fibras de alúmina
Authors: Zamorategui-Molina Adrían , Gutiérrez-Ortega Norma Leticia , Del-Ángel-Soto Julio
Published: February 2020

En muchos países del mundo, incluido México, la presencia de elementos tóxicos, como el arsénico y flúor por encima de los niveles máximos permitidos en el agua potable (0.01 mg/L y 1.5 mg/L), respectivamente está generando problemas a la salud, como el cáncer y la fluorosis esquelética, respectivamente. El objetivo de este trabajo fue determinar la cinética del proceso de adsorción del fluoruro y arsénico en soluciones sintéticas, utilizando gamma alúmina (γ-Al2O3) para establecer si el proceso se desarrolla espontáneamente. Se sintetizó γ-Al2O3 nano-fibrilar, con alta área superficial (352 m2/g), por precipitación homogénea, y se secó por espray. El nanomaterial adsorbente obtenido se usó para eliminar el fluoruro y el arsénico total de soluciones sintéticas. La morfología de la nano-fibra de γ-Al2O3 mesoporosa se analizó usando microscopía electrónica de transmisión y de barrido. El área superficial se determinó por adsorción-desorción a pH 7 de nitrógeno. Las isotermas de adsorción del proceso de remoción coincidieron con el modelo de Langmuir para ambos elementos. La γ-Al2O3 eliminó hasta 96 % de iones flúor y 92 % de arsénico total a pH 5, mientras que a pH 7 se alcanzó una remoción del 90 % y 94.2 % de fluoruro y arsénico, respectivamente. La cinética de remoción siguió el modelo de seudo-segundo orden, y el parámetro de equilibrio adimensional y la energía libre estándar de Gibbs confirmaron que el proceso se desarrolló espontáneamente. La gamma alúmina nano-fibrilar permitió la remoción natural y espontánea de arsénico y fluoruro presente en las soluciones utilizadas en este estudio.
Supervivencia y características de rebrotes en tocones de dos años de cultivos dendroenergéticos
Authors: Ríos-Saucedo Julio César , Acuña-Carmona Eduardo , Valenzuela-Nuñez Luis Manuel , Cancino-Cancino Jorge , Corral-Rivas José Javier , Rosales-Serna Rigoberto
Published: February 2020

Varias especies de los géneros Eucalyptus y Acacia son adecuadas para la producción de biomasa útil en la generación de energía. El objetivo del presente estudio fue evaluar la su-pervivencia y características del rebrote en tocones de cuatro especies dendroenergéticas en tres diferentes densidades poblacionales. Se utilizó un diseño de bloques completos al azar con tres repeticiones, en tres sitios (Parcelas Collipulli, La Aguada y Pilpilco Abajo) con características edafoclimáticas contrastantes. Se estudió Eucalyptus globulus, Eucalyptus denticulata, Eucalyptus nitens y Acacia dealbata en tres densidades de plantación (5 000 árboles/ha; 10 000 árboles/ha y 15 000 árboles/ha). Se evaluó el porcentaje de supervivencia y las características del rebrote por tocón. Las variables especie, densidad de plantación y sitio de siembra afectaron los parámetros analizados. La densidad de plantación afectó el diámetro y altura de los rebrotes dominantes de tipo proventicio en las cuatro especies estudiadas. La mayor tasa de supervivencia de tocones (97 %), la presentó Eucalyptus nitens en Pipilco Abajo, con 79 % de supervivencia de rebrotes a una densidad de 5 000 árboles/ha. Sin embargo, en densidades de 15 000 árboles/ha, la supervivencia de rebrote fue de 29 %. Acacia dealbata es una especie reconocida por su capacidad de colonización, sin embargo, en La Aguada, con densidades de siembra de 5 000 árboles/ha y 10 000 árboles/ha, mostró baja tasa de supervivencia de tocones (19 % y 18 %, respectivamente) y de rebrotes (57 % y 63 %, respectivamente). La especie Eucalyptus globulus mostró altas tasas de supervivencia de tocones y rebrotes en todos los sitios evaluados, por lo que puede ser considerada como una buena opción para optimizar el sistema de monte bajo.
Análisis cognitivos de carga mental e identificación del error humano para mejorar la experiencia de usuario
Authors: Durán-Coronado Adrían Alonso , Maldonado-Macías Aidé Aracely , Barajas-Bustillos Manuel Alejandro , Hernández-Arellano Juan Luis
Published: February 2020

Las personas, en ocasiones, pueden sentirse abrumadas al tratar de interactuar con la tecnología moderna. Ciertos productos de uso cotidiano cuentan con diseños deficientes, por lo que pueden provocar una experiencia insatisfactoria y frustración, produciéndose con ellas una carga mental en el usuario que pueda inducir al error. El uso de técnicas para la identificación del error humano y de la evaluación de carga mental en el diseño y evaluación de productos, puede proporcionar información relevante y útil, para mejorar la experiencia del usuario. El objetivo de este trabajo fue proponer una metodología para integrar la evaluación de carga mental y el análisis del error humano en el diseño de productos. Se evaluó la carga mental mediante la técnica perfil de carga de trabajo, Workload Profile (WP), y se utilizó una metodología de identificación del error humano, Task Analysis For Error Identification (TAFEI), en la configuración de audífonos inalámbricos. Diez usuarios participaron voluntariamente en el estudio; sus experiencias en el uso de los audífonos fueron videograbadas. Se utilizaron formularios para evaluar carga mental, y se identificaron errores humanos durante la etapa de configuración de los audífonos con el teléfono móvil. El método utilizado en este trabajo ofrece una mayor sensibilidad en la evaluación de la carga mental y permite determinar los recursos de atención que más se utilizan en la realización de la tarea. Se detectaron dos oportunidades de rediseño, una relacionada con la señal lumínica, y la otra para la identificación de las puntas para cada oído. A partir de los resultados de la aplicación de la metodología propuesta en este estudio, los diseñadores pueden mejorar la interacción entre las personas y  los productos.
Propiedades de algunos suelos cultivados con cacao en la provincia El Oro, Ecuador
Authors: Barrezueta-Unda Salomón
Published: February 2020

Las propiedades físicas y químicas del suelo, en conjunto, condicionan la capacidad productiva de las plantas. La investigación tuvo como objetivo caracterizar las propiedades de los principales suelos cacaoteros de la provincia de El Oro (Ecuador), en los municipios de El Guabo, Machala, Santa Rosa y Pasaje. Se seleccionaron 30 parcelas, conformadas por los tipos de cacao CCN51 (n = 18) y Nacional (n = 12), de las cuales, se extrajeron muestras de suelo de 0 cm a 30 cm, para analizar varias propiedades físicas y químicas en laboratorio. Los resultados no mostraron diferencias significativas (P > 0.05) entre las propiedades físicas. Los niveles de carbono variaron de 1.58 %  (El Guabo) a 2.06 % (Santa Rosa). En general, el nitrógeno fue bajo (0.16 % a 0.18 %). Los valores de CE (rango; 0.13 dS/m a 0.21 dS/m), pH (rango, 6.46 a 7.72), CIC (23.40 cmol/kg a 43.86 cmol/kg), potasio (0.31 cmol/kg a 1.86 cmol/kg) y calcio (19.99 cmol/kg a 37.73 cmol/kg), tendieron a ser más altos en suelos de Machala (P < 0.05) y más bajos en los de Pasaje. En Santa Rosa, los suelos presentaron concentraciones más altas de cobre (16.6 mg/k) (P < 0.05), que en el resto de los municipios. El rendimiento del cacao CCN51 (2 570.24 kg/ha/a a 4 158.34 kg/ha/a) fue superior a Nacional (324.00 kg/ha/a a 814.17 kg/ha/a). Los suelos de Machala presentaron valores nutrimentales más altos, asociados con el mayor rendimiento promedio para cacao variedad Nacional, y un alto rendimiento para variedad
Diversidad y caracterización de maíces nativos de la Reserva de la Biósfera “El Cielo”, Tamaulipas, México
Authors: González-Martínez Javier , Vanoye-Eligio Venancio , Chacón-Hernández Julio César , Rocandio-Rodríguez Mario
Published: February 2020

La diversidad del maíz en México se fundamenta por la presencia de 59 a 64 razas; Tamaulipas como estado productor contribuye a mantener la variabilidad entre razas, especialmente en las regiones aisladas. La reserva de la Biósfera “El Cielo” localizada en una región montañosa, que comprende los municipios de Jaumave, Ocampo, Gómez Farías y Llera de Canales, ha sido escasamente estudiada, a pesar de que existen riesgos de degradación o extinción de poblaciones nativas de maíz, por factores como cambios de uso de suelo y fenómenos naturales. El objetivo de este trabajo fue analizar la diversidad morfológica de poblaciones nativas de maíz de la Reserva de la Biósfera “El Cielo”. Durante los meses de febrero, marzo y abril del 2016, se realizaron recolectas de maíces nativos en los municipios que comprenden la reserva. El tamaño de la muestra varió, entre 20 y 30 mazorcas de cada población, y de estas, se eligieron 10 mazorcas para registrar variables cuantitativas y cualitativas. Se utilizaron los métodos multivariados de análisis de componentes principales y conglomerados. El 62.45 % correspondió a la variación total, la cual fue explicada por los dos primeros componentes principales, y las variables con mayor contribución a la variación fueron longitud de mazorca, número de granos por hilera, peso de mazorca, peso y volumen de 100 granos, diámetro de mazorca y de olote, número de hileras por mazorca y la relación diámetro/longitud de mazorca. En las poblaciones nativas de maíz que aún se cultivan en la Reserva de la Biósfera “El Cielo”, se encontró amplia diversidad morfológica de mazorca, así como variación en la combinación de colores de grano y olote, lo que sugiere que las poblaciones nativas representan un amplio potencial como acervo genético y reservorio de genes.
Análisis multitemporal de cambios de uso de la tierra en San Fernando, Tamaulipas, durante el periodo 1987 a 2017
Authors: Salinas-Castillo Wilver Enrique , Terrazas-Ruiz Marijose , Mora-Olivo Arturo , Paredes-Hernández Cutberto Uriel
Published: February 2020

El cambio de uso de la tierra (CUT) tiende a impactar de manera negativa los procesos atmosféricos y climáticos globales. El presente artículo tuvo como objetivo evaluar el CUT en el municipio de San Fernando, Tamaulipas, México, durante el periodo 1987 a 2017. Se utilizó el método de clasificación por segmentación de imágenes satelitales, de los años 1987, 1997, 2007 y 2017, el cual, permitió reducir el ruido característico de la clasificación basada en pixeles. Sin embargo, fue necesario editar los resultados, para recuperar los asentamientos humanos, eliminar nubes y sombras, y reducir los efectos de confusión entre cobertura vegetal y zonas agrícolas con cultivos presentes, para evitar introducir CUT artificiales en las estadísticas obtenidas. El análisis multitemporal mostró una clara tendencia en la reducción de la cobertura vegetal (- 6.53 %) y del área sin vegetación aparente (- 1.71 %). También se observó un importante incremento en el uso agrícola (+ 7.61 %), que no pareció. estar asociado a un incremento en asentamientos humanos (+ 0.08 %). La metodología desarrollada parece ser adecuada y fácil de implementar para el análisis de CUT en regiones de interés.
Impacto económico de la adopción de tecnología para la producción de frijol en condiciones de temporal en el norte centro de México
Authors: Borja-Bravo Mercedes , Cuevas-Reyes Venancio , Velez-Izquierdo Alejandra
Published: February 2020

La asignación de recursos públicos a la investigación agropecuaria es un factor de desarrollo para el sector agroalimentario del país, pero deben estar orientados eficientemente hacia la generación de productos tecnológicos que otorguen beneficios a la población. El objetivo de este trabajo fue evaluar el beneficio económico a nivel sistema de producción y sociedad, derivado de la inversión pública en investigación y desarrollo, del paquete tecnológico para la producción de frijol en zonas de temporal de la región norte centro de México. Para evaluar el impacto en los sistemas de producción, se aplicaron 42 encuestas a productores adoptantes del paquete tecnológico en municipios de Aguascalientes y San Luis Potosí; mientras que, para el impacto a nivel sociedad, se estimó el retorno económico que produjo la inversión pública utilizada en el proceso de generación y adopción de la tecnología en el periodo 2009 a 2025. La medición se realizó a través del valor actual neto (VAN), la tasa interna de retorno (TIR) y la relación beneficio costo (R B/C). El costo de producción de los adoptantes fue mayor en 36.3 % comparado con la tecnología tradicional; en tanto que, el rendimiento aumentó en 102 % y el ingreso neto incrementó en 322.6 %. A nivel sociedad, la evaluación reveló un VAN de $ 10.9 millones, lo que representó 4.1 veces lo invertido en la generación de la tecnología. La R B/C fue de 5.1 y la TIR fue mayor a la tasa media real de rendimiento considerada (9.5 %). El desarrollo y transferencia del paquete tecnológico para la siembra de frijol representó una buena inversión de recursos públicos, beneficiando a la población y a los productores, porque incrementa la producción alimentaria y el ingreso neto del agricultor.
Jóvenes y tecnologías digitales. Diagnóstico del uso y apropiación de plataformas digitales en la zona conurbada del sur de Tamaulipas
Authors: Lemus-Pool María Consuelo , Bárcenas-Curtis César , Gómez-Issasi José Alberto
Published: February 2020

En México, existen diversos estudios sobre qué hacen los jóvenes en la red y cómo interactúan en estos entornos; no obstante, en lo referente al sur de Tamaulipas, no existen investigaciones específicas que aborden las características de estas prácticas. El objetivo de este trabajo fue diagnosticar el uso y apropiaciones de plataformas digitales entre jóvenes de la zona sur de Tamaulipas, México, en su calidad de estudiantes del nivel medio superior y superior. La metodología es cuantitativa, a partir de un  diseño no-experimental descriptivo. Se diseñó una muestra estadísticamente representativa de los municipios de Tampico, Ciudad Madero y Altamira, con un 95 % de nivel de confianza; a partir de la que se aplicó un cuestionario que obtuvo la participación de 1 222 jóvenes, en el que, se evaluó la intensidad de uso y perfil de navegación de diversas plataformas digitales, como páginas de información general, de intercambio de información o productos, redes sociales digitales, páginas educativas y de aprendizaje, así como de entretenimiento y diversión. Los hallazgos muestran que los procesos de uso y apropiación de estos entornos están mediados por 2 elementos fundamentales: un componente técnico, referido a los recursos de interactividad que provea la propia plataforma; y un componente sociocultural que remite a la historia de vida, el capital social y cultural, la personalidad y capacidad expresiva, así como las habilidades digitales de los jóvenes. Este estudio, desde lo local, permite observar la homogeneidad en el uso y apropiación de las plataformas digitales de los jóvenes, al tener un sentido pasivo en cuanto al empoderamiento a través de estas herramientas, para aprovechar los potenciales identificados de habilidades digitales, colaboración y producción de contenidos.
2.8 Unique Patterns of Elastin Degradation in Ascending Aortic Aneurysms in Bicuspid Aortic Valve Patients
Authors: Chim Ya Hua , Davies Hannah , Nawaytou Omar , Field Mark , Madine Jillian , Akhtar Riaz
Published: February 2020

Background

Bicuspid aortic valve patients (BAV) are associated with increased risk of ascending aortic aneurysms. However, is unclear whether matrix degradation varies in different ascending aneurysm aetiologies.

Aim

To determine whether the micromechanical and biochemical properties elastin microstructure in BAV-A exhibit unique properties as compared to idiopathic degenerative aneurysm (DA) for the same aortic size.

Methods

Aortic tissue was obtained from patients undergoing aneurysmal repair surgery (BAV-A; n = 15 and DA; n = 15). Coronary artery by-pass graft punch biopsies served as controls (CABG; n = 9). The elastic modulus (E) was measured with nanoindentation for the medial layer. Glycosaminoglycan (GAG), collagen and elastin levels were measured using biochemical assays. Verhoeff Van Gieson-stained sections were imaged for elastin microstructural quantification.

Results

BAV-A had approximately 20% higher E relative to control and DA. There was no significance between DA and controls. Collagen level of BAV-A (36.9 ± 7.4 μg/mg) and DA (49.9 ± 10.9 μg/mg) was higher compared to the control (30.2 ± 13.1 μg/mg). GAG and elastin levels were not significant between the groups. Elastin segments were uniform in controls. Aneurysmal tissues had loss of segments close to the intima and adventitia layers. Although BAV-A and DA had more elastin segments compacted in the media, elastin segments were highly fragmented in DA.

Conclusion

BAV-A has increased stiffness within the aortic wall relative to DA and control tissue. The spatial distribution of elastin demonstrated a unique profile of matrix degradation for BAV-A. The findings of this work are important for the development of future clinical treatment of BAV-A treatment.
Douleur, corps, travail : Fatima, une clinique de la complexité
Authors: Pezé M.
Published: February 2020

L’analyse de la réciprocité des influences entre les registres corporels, psychiques et sociaux de l’être humain est l’objet même d’une clinique de la complexité, sans que l’on puisse dégager une instance ultime qui serait la clé explicative de l’ensemble : l’inconscient, le cerveau, les gènes, le caractère, les relations familiales, la généalogie, le milieu social, le travail et son organisation. Chacun de ces déterminants est à la fois conditionné et conditionnant, produit et producteur. La clinique de la complexité consiste à puiser dans les outils de pensée des uns et des autres pour construire des solutions cliniques.
Introduction
Authors: Shahshahani Soheila
Published: February 2020

In this special issue, not only is the human-environment relationship addressed with a few types of environmental adaptations in rural and urban contexts, including governmental measures and disaster situations, but also the process of culture making is explored through the use of vocabularies in forming mind sets. In this way, a wide spectrum of ideas and situations is portrayed, and the role of culture in making these processes meaningful is shown. The articles in this issue concern Egypt, Turkey, Iran, Afghanistan and they also consider migration. While environmental problems are partial causes for migration, yet symbolic reference to parts of that same environment can symbolise the lost land. The role of poetic language is seen here, while poetry itself becomes a means of better adaptation for a migrant.
A Review of Speech Act Theories Focusing on Searle (1969)
Authors: Saragi Veronica , Nuratika Sikin , Fransiska Fransiska , Yolanda Maya , Ardiyanti Niki
Published: February 2020

Before John Searle wrote the book of Speech Acts, he wrote an article about “What is a Speech Act?” (in Philosophy in America, Max Black, ed. (Ithaca, N.Y.: Cornell University Press, 1965), 221–239). He was born in Denver in 1932. He spent some seven years in Oxford, beginning as an undergraduate in the autumn of 1952 with a Rhodes Scholarship, and concluding as a Lecturer in Philosophy at Christ Church. He has spent almost all of his subsequent life as Professor of Philosophy in Berkeley according to Smith (2003). This article aims to review the speech act theories by Searle (1969) to know what the theories of speech acts according to him to aid researchers understand more on how to apply it in real social life. Moreover, this article’s references are accurate (valid) and they well argued. This article is highly recommended for the philosopher, specialists and analysts in the field of pragmatics, discourse analysis, sociolinguistics and conversational analysis, communication studies who have a significant part in this study. Therefore, this paper seen the speech act theories by Searle (1969) will be more effective if we know and understand more about the speech act theories by Searle (1969) to use it in real social life.
Doppelte Reform mit geteiltem Erfolg: Zur Wirkung der DOPPIK-Reform auf Haushaltsführung und Verwaltungssteuerung in den Kommunen
Authors: Weiß Jens , Schubert Dino
Published: February 2020

Die DOPPIK-Reform war für die kommunalen Verwaltungen in Deutschland eines der zentralen Modernisierungsprojekte der letzten 20 Jahre. Dieser Beitrag untersucht den aktuellen Stand der Implementierung des doppischen Rechnungswesens und managerialistischer Steuerungsinstrumente. Auf Basis einer Sichtung der internationalen Literatur zur Implementierung managerialistischer Formen der Steuerung wird vertiefend untersucht, in welchem Umfang Ansätze des Performance Managements und des Strategischen Managements in Kommunen implementiert wurden und welche Faktoren hierfür relevant sind. Empirische Grundlage ist eine Befragung der Kommunen in Niedersachsen, Nordrhein-Westfalen und Sachsen-Anhalt. Die Ergebnisse zeigen, dass die Umstellung auf eine doppische Rechnungsführung weitgehend vollzogen ist. Eine managerialistische Form der Steuerung wurde dagegen nur in sehr wenigen der untersuchten Kommunen eingeführt. Gleichzeitig ist festzustellen, dass die derzeit verfügbaren theoretischen Modelle zur Erklärung der Implementierung managerialistischer Instrumente in deutschen Kommunen nicht ausreichen.
Konsantre büyüme faktörünün random patern cilt flep yaşayabilirliği üzerine etkisi: deneysel çalışma
Authors: GÜRSOY Koray , KOCA Gökhan , ALIŞIK Murat , YUMUŞAK Nihat , KORKMAZ Meliha , KOÇER Uğur
Published: February 2020

Giriş: Plastik ve rekonstrüktif cerrahide, random patern cilt flepleri çeşitli nedenlerle oluşan doku defektlerinin onarımında sıklıkla kullanılmaktadır. Bu tür fleplerde en sık karşılaşılan sorun yetersiz kan akımına bağlı flep distalinde görülen iskemik nekrozdur. Flep kayıplarını ortadan kaldırmak ve azaltmak için çok sayıda teknik tanımlanmıştır. Bu çalışmadaki amacımız tam kandan elde edilen ve büyüme faktörleri açısından zengin olan konsantre büyüme faktörünün (CGF) daha önce çalışılmamış olan random patern cilt flep yaşayabilirliği üzerine etkisini incelemektir.

Gereç ve Yöntem: Çalışmada 50 adet Spraque –Dawley cinsi sıçan kullanıldı. Sıçanların 40 tanesi deney için, 10 tanesi CGF elde etmek için kullanıldı. Sıçanların sırt bölgelerinden kaldırılan 3x9 cm’lik distal bazlı McFarlene fleplerinin altına çalışma grubunda (n:20) CGF matriks yerleştirildi. Kontrol grubunda (n:20) herhangi bir tedavi uygulanmadı. İşlem sonrası 7. günde değerlendirme için fotoğrafik, sintigrafik ve histopatolojik inceleme yapıldı.

Bulgular: Alan hesaplamaları sonucunda kontrol grubunda flep yaşayabilirlik oranlarının ortanca değerleri %53 (47-58) olarak bulundu. CGF uygulanan grupta ise flep viabilite ortanca oranı %58 (55-64) olarak bulundu. CGF grubunda elde edilen yüksek flep yaşayabilirlik oranları istatistiksel olarak anlamlı bulundu (p<0,001). Sintigrafik perfüzyon alan hesaplamaları sonucunda kontrol grubunda flep yaşayabilirlik oranlarının ortanca değerleri %54 (51-60) iken bu değer CGF uygulanan grupta %61 (59-64)’di. Elde edilen artış istatistiksel olarak anlamlı bulundu (p=0,001). Histopatolojik değerlendirme sonucunda çalışma grubunda elde edilen vaskülarite skorlarının ortanca değerlerinin (10,0 (8,25-11,75)) kontrol grubuna (7,5(6,25-9,00)) göre fazla olduğu görüldü ve bu fark istatistiksel olarak anlamlı bulundu (p=0,003). İnflamasyon skorları açısından gruplar arasında anlamlı farklılık saptanmadı (p=0,246).

Sonuç: Bu çalışmanın sonuçları lokal olarak flep altına uygulanan konsantre büyüme faktörünün flep yaşayabilirliğini artırdığını ve bu etkinin anjiogenez ile ilişkili olabileceği gösterilmiştir ancak bu konuda ileri çalışmalara ihtiyaç vardır. Flep cerrahisinde, iskemi öngörülen durumlarda büyüme faktörlerinden zengin CGF’in uygulanmasının flep yaşayabilirliği üzerine olumlu etkileri olacaktır.
Evaluation of the Possibility of Using the Method of UV Spectrophotometry for the Development of Quantitative Determination of Naftifine Hydrochloride in its Solution with a Combination of PEG for the Treatment of Fungal Infections
Authors: Kosenkova S. I. , Krasnyuk I. I. , Krasnyuk (jr.) I. I. , Belyatskaya A. V. , Stepanova O. I. , Naryshkin S. R.
Published: February 2020

Introduction. An innovative antifungal agent based on hydrochloride with combination of PEG-400 and PEG-1000 has been developed based at the chairs of Sechenov University. This solution is designated for external application as an antifungal agent. Naftifine hydrochloride has a broad spectrum of action against various fungi capable of causing onychomycosis. PEGs, forming part of the developed dosage form, bring about necessary viscosity of the solution (for retention in application area) and do not prevent drug product performance. Naftifine hydrochloride has an apparent UV absorption band with maximum of 256 ± 2 mn, in connection with this, it is supposed to use the UV spectrophotometry method for further development of quantitation method of naftifine hydrochloride detection in tested oral liquid.

Aim. To evaluate the feasibility of using the UV spectrophotometry method for development of quantitation of naftifine hydrochloride in its solution with a combination of PEG for mycotic infection treatment.

Materials and methods. The substance of naftifine hydrochloride, PEG-400 and PEG-1000, ethyl alcohol 96 %, UV spectrophotometry, «Millipore» filter.

Results and discussion. A set of operations was carried out with UV spectrophotometer, including trials of solutions of initial substance of naftifine hydrochloride, PEG solutions, a solution of developed prolonged antimycotic drug and its placebo. The identity of UV spectra of the actual substance in various media was determined, maximum absorption of actual substance and dependence preservation between specified concentration and optical density of the solution were proved. It was found that auxiliary substances included in liquid dosage form do not affect the main characteristics of the UV spectrum of actual substance.

Conclusion. The possibility in principle of using the UV spectrophotometry method for quantitative and qualitative analysis of innovative prolonged antimycotic drug – liquid dosage form of naftifine hydrochloride with a combination of PEG has been established.
Application of Luminescent Microscopy in Analysis of Anatomic-diagnostic Signs of Fruits of Sea Buckthorn
Authors: Trineeva O. V. , Gudkova A. A. , Rudaya M. A.
Published: February 2020

Introduction. Sea buckthorn (Hippophae rhamnoides), the family Eleagnaceae – a promising source of biologically active substances, the traditional raw materials of which are fruits. The existing regulatory documentation (ND) lacks such an indicator of the authenticity and good quality of the fruit as «microscopy». Despite the available data on the anatomy and histology of the fruits of this type of medicinal plant material (MPM), the scientific literature does not describe the luminescence features of the tissues of sea buckthorn fruit. It is known that the luminescent features of tissues make it possible to identify the localization of biologically active structures, and also, in some cases, to conduct selective diagnosis of MPM.

Aim. The aim of this work was to study the characteristics of the luminescence of the tissues of dried crushed fruits of sea buckthorn, and also to optimize the conditions for analysis.

Materials and methods. The object of the study was the dried, crushed fruits of sea buckthorn of various species. The study of microdiagnostic signs was carried out according to the State Pharmacopoeia of the XIV RF GPA.1.5.3.0003.15 «Technique of microscopic and microchemical studies of medicinal plant materials and herbal medicines». A stereomicroscopic study was carried out on a Biomed-6 microscope. The luminescence of sea buckthorn fruit tissues was examined using a luminescent microscope of the Micromed-3 Lum brand.

Results and discussion. The most pronounced yellow glow is observed for the tissue of the pulp and epidermis of the fetus, which is associated with the highest content of fatty oil in these structures. Groups of phenolic compounds contained along with oil give a greenish tint to objects, while condensed tannins give a brownish tint. The plates that make up the corymbose hairs do not exhibit bright luminescence; a weak glow is characteristic of the joints of the hair platelets. The walls of stellate hairs have a faint greenish glow. Fragments of the actual fruit («sac») are brownish in color, without their own luminescence, as well as the seed peel. The embryo has its own greenish luminescence due to the presence of both a fatty oil and a complex of storage substances.

Conclusion. The luminescent analysis of sea buckthorn fruits was carried out for the first time. The choice of a method for preparing the studied MPM for microscopic examination is experimentally substantiated. The luminescent analysis revealed the peculiarities of the glow of the tissues of the fruits of sea buckthorn. The main microdiagnostic signs of crushed dried sea buckthorn fruits and their biometric characteristics are specified. The analysis of the obtained data will allow us to further develop the section «Microscopic signs» for inclusion in the PA project on MPM, widely cultivated and used by the domestic pharmaceutical industry for the production of herbal medicines.
Formation of Docetaxel-related Substances in the Polymer Particles During Storage and Gamma-treatment
Authors: Poltavets Yu. I. , Aleshin S. V. , Zavarzina V. V. , Murav’eva A. I. , Soboleva A. A. , Tubasheva I. A. , Kuznetsov S. L.
Published: February 2020

Introduction. Docetaxel is widely used for cancer treatment. Actual issue for newly developed polymer-based Docetaxel formulations is applicability of current quality requirements. The technology of polymeric forms, including gamma-sterilization, are differ from actual Docetaxel injections technology. In this study were used PLGA-based particles with Docetaxel. The main attention was directed to studying qualitative and quantitative content of related impurities in polymeric forms during long-term storage and gamma-sterilization in comparison with pharmacopoeial requirements for Docetaxel injections.

Aim. Studying of possible patterns of Docetaxel-related impurities formation between intact and gamma-irradiated batches.

Materials and methods. Objects of study – lyophilizates of Docetaxel polymeric forms was previously obtained by the authors. Qualitative and quantitative analysis was performed by high pressure liquid chromatography.

Results and discussion. Docetaxel-related impurities was determined and evaluated in the intact and gamma-treated batches. It was cleared, that related substances in the gamma-treated batches was different in comparison with non-treated but after vary storage periods.

Conclusion. Docetaxel-loaded polymeric drugs shown proper stability during long term storage. The influence of gamma-treatment to Docetaxelrelated impurities content was found. Gamma sterilization can be promising method for novel drugs, but it needs individual study in the each case.
Las Pequeñas y Medianas Empresas (PyME) en el contexto de la Innovación Abierta: una síntesis teórica
Authors: García Garnica Alejandro
Published: February 2020

El objetivo del artículo es describir y sintetizar, de manera general, el estado de las Pequeñas y Medianas Empresas (Pymes) en el contexto del modelo de innovación abierta. Este trabajo se enfoca en algunas de las ideas de Henry Chesbrough, y la de sus seguidores, uno de los autores más reconocidos en impulsar y difundir dicha propuesta. Se resalta la necesidad que tienen las Pymes de abrir sus fronteras a la búsqueda y asimilación de conocimientos externos y aprovechar sus recursos internos, así como de crear lazos estrechos de colaboración con su contexto. Estas empresas necesitan impulsar modelos de negocio que satisfagan las necesidades de sus clientes, a partir de la adopción de diferentes prácticas estratégicas de exploración y explotación, y con el fin de elevar su competitividad.
Sistema Único Integrado de Gestión: Calidad, Ambiente, Seguridad y Salud
Authors: Cuadros Domínguez Juan Froylán , Téllez Gaytán Jesús Cuauhtémoc
Published: February 2020

El artículo propone un Sistema Único Integrado (SUI) para fortalecer los sistemas de gestión ISO 9001, ISO 14001, OHSAS 18001 y Código ISM de cuatro unidades de negocio de un corporativo que opera en la industria petrolera marina en Méjico, en un entorno competitivo. La investigación es cuantitativa y parte del análisis de procesos, la consulta y selección de elementos específicos para mejorar la competitividad y desarrollar una propuesta de SUI alineada con el control interno. Se plantean indicadores de desempeño de procesos y se implementan a través de un diagrama de Gantt. Las limitaciones que se presentan son la persistencia para manejar, en forma independiente, los resultados financieros de los proyectos y la falta de sinergias para hacer más eficiente la organización.
PECULIARITIES OF COBALT CONTAINING OXIDE COATINGS FORMATION ON SILUMIN
Authors: Sakhnenko Nikolay , Ved’ Maryna , Karakurkchi Ann
Published: February 2020

The process of mixed oxide coatings formation on a high-silicon aluminum alloy in a cobalt-containing pyrophosphate electrolyte by the plasma-electrolytic oxidation (PEO) method is studied. It was shown that AL25 chemical composition heterogeneity causes the consumption of a part of the anode current to homogenize the treated surface, which is reflected in minimizing the content of doping components at the initial processing stage. It was established that the growth of mixed oxides Al2O3·CoxOy relative mass is a function of time with a maximum at 55 minutes. The chemical, phase composition and surface morphology of the formed oxide layer depend on the oxidation time. The catalytic component content in the surface oxides varies from 0.2 to 23.3 at.% with an increase in processing time of 10 to 60 minutes. Maximum cobalt incorporation into the oxide layer occurs at PEO of 35–50 minutes, while the silicon content in the surface layers does not exceed 2 at.%, which is favorable for the catalytic properties. The cobalt oxide, preferably Co3O4, incorporation in the alumina α-Al2O3 matrix is visualized by the blue-violet color steroidal surface structures in the sites of micro-arc discharges. The alumina cobalt oxide mixture layers are characterized by a developed micro-globular surface which consists of spheroid conglomerate with an average size of 1–2 microns. There are some amorphous phases in the structure of mixed oxides due to non-equilibrium PEO conditions. The set of detected factors is a prerequisite for the high catalytic properties of oxide coatings. A promising field of Al2O3·CoxOy systems application is intra-cylinder catalysis in internal combustion engines.
Compressed Life Review: Extreme Manifestation of Autobiographical Memory in Eye-Tracker
Authors: Nourkova Veronika V.
Published: February 2020

The compressed life review (CLR) is a mnemonic illusion of having “your entire life flashing before your eyes”. This research was guided by concerns over the retrospective methodology used in CLR studies. To depart from this methodology, I considered the long-term working memory (WM), “concentric”, and “activation-based” models of memory. A novel theoretically rooted laboratory-based experimental technique aimed to elicit the CLR-like experience with no risk to healthy participants was developed. It consists of listening to superimposed audio recordings of previously trained verbal cues to an individually composed set of self-defining memories (SDMs). The technique evoked a self-reported CLR-like experience in 10 out of 20 participants. A significant similarity in eye movement patterns between a single SDM condition and a choir of SDM conditions in self-reported CLR experiencers was confirmed. In both conditions, stimuli caused relative visual immobilization, in contrast to listening to a single neutral phrase, and a choir of neutral phrases that led to active visual exploration. The data suggest that CLR-like phenomenology may be successfully induced by triggering short-term access to the verbally cued SDMs and may be associated with specific patterns of visual activity that are not reportedly involved with deliberate autobiographical retrieval.
Functions of Vertebrate Ferlins
Authors: Bulankina Anna V. , Thoms Sven
Published: February 2020

Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six ferlin genes encoding, in humans, dysferlin, otoferlin, myoferlin, Fer1L5 and 6 and the long noncoding RNA Fer1L4. Mutations in DYSF (dysferlin) can cause a range of muscle diseases with various clinical manifestations collectively known as dysferlinopathies, including limb-girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi myopathy. A mutation in MYOF (myoferlin) was linked to a muscular dystrophy accompanied by cardiomyopathy. Mutations in OTOF (otoferlin) can be the cause of nonsyndromic deafness DFNB9. Dysregulated expression of any human ferlin may be associated with development of cancer. This review provides a detailed description of functions of the vertebrate ferlins with a focus on muscle ferlins and discusses the mechanisms leading to disease development.
Assessing the Importance of Biomass-Based Heating Systems for More Sustainable Buildings: A Case Study Based in Spain
Authors: Pardo Juan E. , Mejías Ana , Sartal Antonio
Published: February 2020

Climate change, other environmental impacts due to increased energy use worldwide, and the exhaustion of energy resources are some of the major challenges facing today’s society. Considering this, this paper assesses the importance of biomass-based heating and hot-water systems in the achievement of more sustainable buildings. Using a simplified calculation method, we jointly analyzed the potential operational cost savings and reduction of CO2 emissions that would be achieved when the traditional energy model, based on the use of fossil fuels, is replaced by biomass-based heating systems. Evidence stems from a case study in public buildings in the province of Pontevedra, in the northwest of Spain. The results of this research not only show a huge impact on CO2 emission reduction just by adapting the kind of fuel use, but also considerable annual cost reduction without compromising activity development and workers’ comfort. Thus, the findings obtained should encourage governments to support the transition toward cleaner sources of energy, acting as first movers toward a locally produced and renewable-based energy supply.
A New Design for Wood Stoves Based on Numerical Analysis and Experimental Research
Authors: Motyl Przemysław , Wikło Marcin , Bukalska Julita , Piechnik Bartosz , Kalbarczyk Rafał
Published: February 2020

This work proposes a comprehensive approach to modifying the design of wood stoves with a heating power up to 20 kW, including design works, simulations, and experimental research. The work is carried out in two stages. In the first part, a numerical model is proposed of the fireplace insert including fluid flow, the chemical combustion reaction, and heat exchange (FLUENT software is applied to solve the problem). The results of the simulation were compared with the experiment carried out on the test bench. A comparison of the experimental and numerical results was made for the temperature distribution along with the concentration of CO, CO2, and O2. Construction changes were proposed in the second stage, together with numerical simulations whose goal was an increase in the efficiency of the heating devices. The results obtained show that the average temperature in the chimney flue, which has a low value that is a determinant of the higher efficiency of the heating devices, was reduced relative to the initial design of the fireplace intake by 11%–16% in all cases. The retrofit enhanced stable heat release from the wood stove, which increased the efficiency and reduced the harmful components of combustion.
Seasonal Variability of the Acoustic Climate of Ski Resorts in the Aosta Valley Territory
Authors: Tibone Christian , Masoero Marco , Berlier Filippo , Tabozzi Giovanni , Crea Daniele , Tartin Christian , Cappio Borlino Marco , Agnesod Giovanni
Published: February 2020

The Aosta Valley is an alpine region in north-west Italy that is characterized by a high level of naturalness, with extensive uninhabited areas that are distant from artificial sound sources. The Aosta Valley Regional Environmental Protection Agency (ARPA-VdA) has been particularly sensitive to the preservation of the soundscape, which is considered an integral part of the landscape, since the laws on noise pollution were first introduced. The nature of the ski areas in the Aosta mountains, which undergoes changes throughout the year, is surely of great importance, especially during the winter season, when the number of visitors is particularly high. In fact, during the winter, the sounds of nature are replaced by those produced by recreation and sports activities. Mountain and snow tourism, which are developed in sensitive environmental contexts in the Aosta Valley, are sectors of immense social and economic importance. Much of this tourism takes place in ski resorts. Three mountain areas with different characteristics, in terms of attendance and recreational/sport activities, have been examined in this paper, as part of a collaboration between ARPA-VdA and the Politecnico di Torino. Acoustic measurements were performed in order to identify the seasonal variations of sound emissions from both natural and anthropic sound sources. In addition to the standard environmental acoustic descriptors foreseen by European legislation (LAeq, Ln, Lden, etc.), the harmonica (IH) index, which provides a quantitative evaluation of the acoustic quality on a zero to ten numerical scale, was used to qualify the acoustic climate of the three areas. The results presented in the paper provide useful information on a relevant subject—the preservation of the acoustic quality of a mountain area of touristic importance—which has been scarcely investigated so far.
Hybrid Assessment Scheme Based on the Stern- Judging Rule for Maintaining Cooperation under Indirect Reciprocity
Authors: Okada Isamu , Yamamoto Hitoshi , Uchida Satoshi
Published: February 2020

Intensive studies on indirect reciprocity have explored rational assessment rules for maintaining cooperation and several have demonstrated the effects of the stern-judging rule. Uchida and Sasaki demonstrated that the stern-judging rule is not suitable for maintaining cooperative regimes in private assessment conditions while a public assessment system has been assumed in most studies. Although both assessment systems are oversimplified and society is most accurately represented by a mixture of these systems, little analysis has been reported on their mixture. Here, we investigated how much weight on the use of information originating from a public source is needed to maintain cooperative regimes for players adopting the stern-judging rule when players get information from both public and private sources. We did this by considering a hybrid-assessment scheme in which players use both assessment systems and by using evolutionary game theory. We calculated replicator equations using the expected payoffs of three strategies: unconditional cooperation, unconditional defection, and stern-judging rule adoption. Our analysis shows that the use of the rule helps to maintain cooperation if reputation information from a unique public notice board is used with more than a threshold probability. This hybrid-assessment scheme can be applied to other rules, including the simple-standing rule and the staying rule.
Circular Geodesics Stability in a Static Black Hole in New Massive Gravity
Authors: Aceña Andrés , López Ericson , Aldás Franklin
Published: February 2020

We study the existence and stability of circular geodesics in a family of asymptotically AdS static black holes in New Massive Gravity theory. We show that the mathematical sign of the hair parameter determines the existence of such geodesics. For a positive hair parameter, the stability regions follow the usual pattern, with the innermost geodesic being null, unstable, and separated from the horizon, followed by a region of unstable timelike geodesics and then a region of stable timelike geodesics, which extends in the asymptotic region.
Hydropriming and Biopriming Improve Medicago truncatula Seed Germination and Upregulate DNA Repair and Antioxidant Genes
Authors: Forti Chiara , Shankar Ajay , Singh Anjali , Balestrazzi Alma , Prasad Vishal , Macovei Anca
Published: February 2020

Seed germination is a critical parameter for the successful development of sustainable agricultural practices. While seed germination is impaired by environmental constraints emerging from the climate change scenario, several types of simple procedures, known as priming, can be used to enhance it. Seed priming is defined as the process of regulating seed germination by managing a series of parameters during the initial stages of germination. Hydropriming is a highly accessible and economic technique that involves soaking of seeds in water followed by drying. Biopriming refers to the inoculation of seeds with beneficial microorganism. The present study aims to investigate whether hydropriming and biopriming could enhance seed germination. Thereby, the germination of Medicago truncatula seeds exposed to hydropriming and/or Bacillus spp. isolates was monitored for two-weeks. The seeds were sown in trays containing two types of in situ agricultural soils collected from Northern India (Karsara, Varanasi). This region is believed to be contaminated by solid waste from a nearby power plant. Phenotypic parameters had been monitored and compared to find the most appropriate combination of treatments. Additionally, qRT-PCR was used to evaluate the expression levels of specific genes used as molecular indicators of seed quality. The results show that, while hydropriming significantly enhanced seed germination percentage, biopriming resulted in improved seedling development, represented by increased biomass rather than seedling length. At a molecular level, this is reflected by the upregulation of genes involved in DNA damage repair and antioxidant defence. In conclusion, hydropriming and biopriming are efficient to improve seed germination and seedling establishment in soils collected from damaged sites of Northern India; this is reflected by morphological parameters and molecular hallmarks of seed quality.