bluuebunny/crossref_metadata_2025 huggingface dataset:
The unveiling of a dynamic duo; hydrodynamic cavitation and cold plasma for the degradation of furosemide in wastewater
Authors: Verdini Federico , Abramova Anna , Boffa Luisa , Gaudino Emanuela Calcio , Cravotto Giancarlo
Published: January 2024

The degradation in water of furosemide (FUR), a widely used diuretic drug, was herein reported. The method entails an integrated approach based on the hybridisation of hydrodynamic cavitation (HC) with electrical discharge (ED) plasma technology. This dynamic duo could increase the production of oxidising compounds in water, in particular hydroxyl radicals (OH radicals), by triggering the rapid homolytic decomposition of water molecules and avoiding the addition of external oxidants. This study clearly emphasises the effectiveness of an integrated approach to improve the degradation of pollutants in wastewater originating from active pharmaceutical ingredients (APIs). The results of HC/ED-assisted FUR degradation in the presence of radical scavengers highlight the predominant role of the radical oxidation mechanism at the gas-liquid interface of the cavitation bubble during HC/ED treatment. A comparative analysis of the three technologies — HC alone, HC/ED and UV alone — emphasised the promising potential of hybrid HC/ED as a scalable industrial technology. This is demonstrated by the higher degradation rates (100%, 10 min) when treating large volumes (5L) of wastewater contaminated with FUR (50mg/L), even in the presence of other APIs.
Pan‑cancer Analysis of LAP2α as a Potential Prognostic and Immunological Biomarker for Multiple Cancer Types Including Glioma
Authors: Wang Danwen , Yu Donghu , He Yongze , Tang Feng , Pan Zhiyong , Wang Zefen , Ma Chao , Li Zhiqiang
Published: January 2024

LAP2α, a variant of the lamin-associated polypeptide 2 (LAP2) family, is crucial for in the process of nuclear structure organization and maintaining genomic stability. This research was aimed to investigate the involvement of LAP2α in cancer development, especially in glioma. Based on public datasets, we found LAP2α was upregulated in most cancers, and the survival analysis indicated a distinct correlation between elevated LAP2α expression and unfavorable prognosis among glioma patients with elevated levels of macrophage and neutrophil. LAP2α level evidently associated with the immune checkpoint therapy related genes in cancers. Specifically, we made the tissue microarray covered 80 glioma patients with prognostic analysis, and verified that reducing LAP2α hindered the growth and movement capacity of the glioma cells. Our data suggests that LAP2α may be an important tool for indication of immunotherapy and medical prognosis in pan-cancer, and is expected to have a critical role in the oncogenesis of glioma.
ACSS3 promotes the tumorigenesis of non-small cell lung cancer via suppressing p53-mediated ferroptosis
Authors: Zhang Jing , Wang Xiuhong , Wang Jingyi , Wen Xiao , Chen Siyuan , Wang Tao , Wang Bei , Hu Wenquan
Published: January 2024

Purpose
Non-small cell lung cancer (NSCLC) is a subtype of the most frequently diagnosed cancer, causing a considerable number of deaths globally. Mitochondrial dysfunction has been observed to promote malignant progression. However, the underlying mechanism is still unclear. Acyl-CoA synthetase short chain family member 3 (ACSS3) is mainly located in mitochondria, which abnormal regulation is usually accompanied by the occurrence and development of tumors. This study aimed to evaluate the potential role of ACSS3 in the tumorigenesis of NSCLC.
Methods
The impact of ACSS1 and ACSS3 expression levels on the survival rates of NSCLC patients was examined by online database. ACSS3 protein expression in 79 NSCLC samples and 79 adjacent tissues was evaluated by immunohistochemistry (IHC). The effect of ACSS3 on proliferation, migration and invasion of NSCLC and the molecular mechanism were investigated through in vitro experiments and xenograft tumor.
Results
ACSS3 expression level was correlated with the poor prognosis of NSCLC patients. ACSS3 knockdown led to mitochondrial contraction, increased ROS levels, decreased mitochondrial membrane potential, and subsequently inhibited growth of NSCLC cells in vitro and in vivo, while ACSS3 overexpression promoted these processes. Mechanistically, ACSS3 deficiency promoted ferroptosis through transcriptional control of SLC7A11 and GPX4. Further investigations found that loss of ACSS3 inhibited the SLC7A11/GPX4 axis by enhancing the stability of p53.
Conclusion
ACSS3 promotes NSCLC tumorigenesis through inhibiting the p53-mediated ferroptosis. As such, ACSS3 should be considered a new potential therapeutic target for the treatment of NSCLC.
Hematologists’ perspective on Advance Directives, a French national prospective cross-sectional survey – the ADORE-H Study
Authors: Serey Kevin , Cambriel Amélie , Pollina-Bachellerie Adrien , Bay Jacques-Olivier , Bouleuc Carole , Ladrat Laure , Lotz Jean-Pierre , Philippart Francois
Published: January 2024

Background: The onset of hematological malignancy can lead to acute and critical situations. It can also lead to adverse outcome despite the major advancements made in their therapeutic management. In this context, advance care planning and, in particular, advance directives (AD) play an essential role. However, using AD in patients with malignant hemopathies remains very rare.
Methods: The aim was to evaluate the perception of AD by hematologists. We made a French national online survey. All hematologist working in a hospital setting ant treating malignant hemopathies were solicited. The questionnaire covered 5 areas: personal perception of AD; assistance in writing AD; patient information about AD; use of ADs; demographic data.
Results: 318 hematologists (33.7% of the whole population), working in 103 different centers across France participated in the study. 72.6% (n=231) of the respondents considered that AD could be interesting for patient’s care. Only 32.7% talked about AD with their patients on a regular basis. The lack of use was correlated with the fear of creating anxiety for the patient (64.9%; n = 172) or in relatives (30.9%; n = 80), or the fact that AD were deemed to be inappropriate in their patients (57.8%; n = 145). 19.5% (n = 62) of the responding hematologist offer patients their help to write AD. This proportion is higher in physicians who previously work in palliative care unit (35,6 % vs 16,8 %, p = 0,0004).
Interpretation: The majority of the interrogated hematologist have a positive opinion on AD, but only a few of them break the matter to their patients. The fear of patients and relatives’ consequences, especially anxiety, remains the main limit to information about AD.
Prognostic impact of metabolic syndrome in patients with primary endometrial cancer: A retrospective bicentric study
Authors: Shehaj Ina , Krajnak Slavomir , Rad Morva Tahmasbi , Gasimli Bahar , Hasenburg Annette , Karn Thomas , Schmidt Marcus , Müller Volker , Becker Sven , Gasimli Khayal
Published: January 2024

Purpose Endometrial cancer (EC) is the most common gynaecological cancer. Its incidence has been rising over the years with ageing and increased obesity of the high-income countries’ populations. Metabolic syndrome (MetS) has been suggested to be associated with EC. The aim of this study was to assess whether MetS has a significant impact on oncological outcome in patients with EC.
Methods This retrospective study included patients treated for EC between January 2010 and December 2020 in two referral oncological centers. Obesity, arterial hypertension (AH) and diabetes mellitus (DM) were criteria for the definition of MetS. The impact of MetS on progression free survival (PFS) and overall survival (OS) was assessed with log-rank test and Cox regression analyses.
Results Among the 415 patients with a median age of 64, 38 (9.2%) fulfilled the criteria for MetS. The median follow-up time was 43 months.
Patients suffering from MetS did not show any significant differences regarding PFS (36.0 vs. 40.0 months, HR: 1.49, 95% CI 0.79-2.80 P=0.210) and OS (38.0 vs. 43.0 months, HR: 1.66, 95% CI 0.97-2.87, P=0.063) compared to patients without MetS. Patients with obesity alone had a significantly shorter median PFS compared to patients without obesity (34.5 vs. 44.0 months, P=0.029). AH and DM separately had no significant impact on PFS or OS (p>0.05).
Conclusion In our analysis, MetS in patients with EC was not associated with impaired oncological outcome. However, our findings show that obesity itself is an important comorbidity associated with significantly reduced PFS.
Electrophysiological and behavioral responses of cabbage aphid (Brevicoryne brassicae) to rosemary (Rosmarinus officinalis) volatiles, a potential push plant for vegetable push-pull cropping system
Authors: Mutua Bretor Katuku , Dubois Thomas , Akutse Komivi Senyo , Muli Benjamin , Karanja Edward Nderitu , Mutyambai Daniel Munyao
Published: January 2024

The cabbage aphid (Brevicoryne brassicae) is a major pest of kale (Brassica oleraceae var. acephala), an important vegetable that is grown worldwide due to its high nutritional and economic value. Brevicoryne brassicae poses a great challenge to B. oleraceae var. acephala production, causing significant direct and indirect yield losses. Farmers overly rely on synthetic insecticides to manage the pest with limited success owing to its high reproductive behavior and development of resistance. This necessitates search for sustainable alternatives to mitigate these challenges. This study assessed behavioral responses of B. brassicae to odors from rosemary (Rosmarinus officinalis) and B. oleraceae var. acephala headspace volatiles in a Perspex four-arm olfactometer. We identified and quantified volatiles emitted by each of the two plants and those eliciting behavioral response using coupled gas chromatography-mass spectrometry (GC-MS) and gas chromatography-electroantennogram (GC-EAG), respectively. Our findings revealed that B. brassicae spent more time in the arms of the olfactometer that contained B. oleraceae var. acephala volatiles compared to the arm that held R. officinalis volatiles. GC-MS analysis revealed diverse and higher quantities of volatile compounds in R. officinalis compared to B. oleraceae var. acephala. GC-EAG showed that B. brassicae was responsive to linalool, camphor, borneol, α-terpineol, verbenone, geraniol and bornyl acetate from R. officinalis and sabinene, γ-terpinene, and β-caryophyllene from B. oleraceae var. acephala. Our findings demonstrate that R. officinalis is repellent against B. brassicae and could be utilized as a ‘push’ plant in an intercropping strategy against this pest.
SALL4 deletion and renal and cardiac defects associated with VACTERL association
Authors: Watanabe Daisuke , Nakato Daisuke , Yamada Mamiko , Suzuki Hisato , Takenouchi Toshiki , Miya Fuyuki , Kosaki Kenjiro
Published: January 2024

Congenital Anomalies of the Kidney and Urinary Tract [CAKUT] can be a part of the VACTERL association, which represents the non-random combination of the following congenital anomalies: Vertebral anomalies, anal anomalies, cardiac anomalies, tracheal-esophageal anomalies, renal anomalies, and limb anomalies. VACTERL association is generally considered to be a non-genetic condition. Exceptions include a patient with a heterozygous nonsense SALL4 variant and anal stenosis, tetralogy of Fallot, sacro-vertebral fusion, and radial and thumb anomalies. SALL4 encodes a transcription factor that plays a critical role in renal morphogenesis. Here we report a patient with VACTERL association and a heterozygous 128-kb deletion spanning SALL4 who presented with renal hypoplasia, radial and atrio-septal defects, and patent ductus arteriosus. The present report of SALL4 deletion, in addition to a previously reported patient with VACTERL association phenotype and SALL4 nonsense mutation, further supports the notion that SALL4 haploinsufficiency can lead to VACTERL association.
Occlusion-aware heatmap generation for enhancing 3D human pose estimation in multi-person environments
Authors: Lee Sanghyeon , Lee Jong Taek
Published: January 2024

In multi-person 3D human pose estimation (HPE), the lack of diverse and accurate 3D pose datasets remains a critical challenge. Despite recent advancements in learning-based methods, real-world scenarios with varied environments and individuals often lead to data biases and sparse annotations, complicating the achievement of robust generalization in visual computing applications. While recent data augmentation methods have shown promise in enhancing the generalization of 3D HPE, the majority target single-person settings, leaving multi-person scenarios insufficiently covered. Our paper presents a novel data augmentation technique for multi-person 3D HPE. We refine the data evolution framework to generate new single-person 3D poses and then combine them into multi-person scenarios. Notably, our method generates occlusion-aware 2D heatmaps by considering camera positions, 3D poses, and joint-specific occlusion uncertainties, capturing the nuances of real-world pose challenges. Evaluations on well-known datasets, such as CMU Panoptic, Shelf, and Campus, demonstrate our method's effectiveness, especially in constrained data environments. The code and dataset are available at: https://github.com/hyeon0819/MPDA.
WTGCN: Wavelet Transform Graph Convolution Network for Pedestrian Trajectory Prediction
Authors: Chen Wangxing , Sang Haifeng , Wang Jinyu , Zhao Zishan
Published: January 2024

The task of pedestrian trajectory prediction remains challenging due to variable scenarios, complex social interactions, and uncertainty in pedestrian motion. Previous trajectory prediction research only models from the time domain, which makes it difficult to accurately capture the global and detailed features of complex pedestrian social interactions and the uncertainty of pedestrian movement. These methods also ignore the relationship between scene features and the potential motion patterns of pedestrians. Therefore, we propose a wavelet transform graph convolution network to obtain accurate pedestrian potential motion patterns through time-frequency analysis. We first construct spatial and temporal graphs, then obtain the attention score matrices through the self-attention mechanism in the time domain and combine them with the scene features. Then, We utilize the two-dimensional discrete wavelet transform to generate low-frequency and high-frequency components for representing global and detailed features of spatial-temporal interactions. These components are then further processed using the asymmetric convolution, and the wavelet transform adjacency matrix is obtained through the inverse wavelet transform. We then employ graph convolution to combine the graph and the adjacency matrix to obtain spatial and temporal interaction features. Finally, we design the wavelet transform temporal convolution network to directly predict the two-dimensional Gaussian distribution parameters of the future trajectory. Extensive experiments on the ETH, UCY, and SDD datasets demonstrate that our method outperforms the state-of-the-art methods in prediction performance.
Management of Neglected Post-traumatic C4/C5 Spondyloptosis in a Low Resource Setting: a Review of Literature and Case Study.
Authors: Anele Christopher , Ezeaku Chizowa , Balogun Simon , Ajekwu Temitope , Ejembi Gabriel , Komolafe Edward
Published: January 2024

Objectives
To highlight the incidence, outcome, and peculiar management challenges of cervical spondyloptosis
Methods
A retrospective literature review and case study
Results
Five cases of subaxial cervical spondyloptosis were identified from the literature and reviewed. Their demographics, mechanisms of trauma, intervention, and outcome were highlighted.
Conclusion
Subaxial cervical spondyloptosis is relatively uncommonly documented in the literature. The management outcomes are variable, and peculiar management challenges are highlighted in the index case study.
Characteristics of congruent dissolution of silicate minerals enhanced by chelating ligand under ambient conditions
Authors: Wang Jiajie , Nurdiana Astin , Sato Yoshinori , Watanabe Noriaki , Tsuchiya Noriyoshi
Published: January 2024

Natural and anthropogenic chelating ligands play important roles in promoting mineral dissolution during water-rock interactions. To address the remaining issue of how chelating ligands participate in the dissolution of minerals, this study investigated the dissolution characteristics of seven types of silicate minerals in the presence of a chelating ligand, N,N-bis(carboxymethyl)-L-glutamic acid (GLDA), which is a glutamic acid derivative, through batch dissolution experiments. The results showed that the dissolution of all types of silicate minerals, i.e., olivine (nesosilicate), epidote (sorosilicate), tourmaline (cyclosilicate), enstatite (single-chain inosilicate), hornblende (double-chain inosilicate), biotite (phyllosilicate), and anorthite (tectosilicate), can be enhanced by up to two orders of magnitude at both pH 4 and 8. The chelating ligand particularly facilitated the dissolution of minerals with a higher Al content, such as tourmaline and anorthite. Furthermore, the presence of chelating ligands enhanced the leaching of not only metals but also Si from minerals, resulting in a more congruent characteristic of mineral dissolution. A possible mechanism is that the chelating ligand adsorbs onto the negatively charged the mineral surface, which attracts more H+ and polarizes Si-O and Mg-O bonds, thereby dissolving the minerals at a faster rate. These results have significant implications for understanding the dissolution of minerals in nature and for the application of chelating agents in geological and materials engineering.
Programação na educação básica: Discussões a partir de uma oficina com professores em formação inicial e continuada
Authors: Da Rocha Flavia Sucheck Mateus , Elias Ana Paula de Andrade Janz , Motta Marcelo Souza
Published: January 2024

As discussões contemporâneas sobre o uso de tecnologias digitais na escola apontam para o desenvolvimento do pensamento computacional, a partir de atividades de programação. Com o intuito de proporcionar um contato do professor e do futuro professor com essas atividades e possibilitar reflexões sobre a inserção delas nas escolas, realizou-se uma oficina formativa, com 27 participantes. Os dados produzidos com a oficina foram utilizados para a realização de uma investigação qualitativa que objetivou analisar se os participantes passariam a identificar a programação como uma possibilidade viável na Educação Básica. Por meio de um estudo de caso, analisou-se os dados referentes ao registro dos relatos dos cursistas durante a oficina, a um mural virtual com uma atividade de programação e a um questionário realizado no Google Forms. A análise mostrou que a oficina propiciou ampliação do conhecimento dos cursistas acerca da própria programação, da escolha de recursos para crianças e das habilidades que podem ser desenvolvidas. A oficina também criou a oportunidade de discussões coletivas que suscitam reflexões sobre a prática docente. A totalidade dos cursistas relatou que passou a compreender que é possível realizar atividades de programação, já nas séries iniciais do Ensino Fundamental.
Pesquisas sobre portfólios reflexivos na formação de professores: Contribuições e Críticas
Authors: Antiqueira Liliane , Pereira Elaine Corrêa , Galiazzi Maria do Carmo
Published: January 2024

Neste texto, apresentamos a análise de 40 artigos sobre portfólios reflexivos a partir de um mapeamento bibliográfico de 209 documentos sobre portfólios na formação de professores, em artigos de revistas brasileiras online com Qualis A e B e revistas com revisão por pares em língua espanhola e em língua inglesa a partir do Portal Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES, abrangendo o período de 1988 a 2020. O objetivo foi compreender o uso de portfólios reflexivos na formação de professores. Para a metodologia foi utilizada a Análise Textual Discursiva em uma abordagem fenomenológica hermenêutica. De cada categoria foram apresentadas sínteses exemplares. A seguir trazemos argumentos críticos presentes na literatura sobre o movimento do professor reflexivo como conceito estruturante da formação de professores. Argumentamos, ao final, que caso sejam adotados portfólios reflexivos, sejam esclarecidos a teoria em que se situa a reflexão. A nosso ver, os portfólios reflexivos valerão o esforço caso estejam vinculados a ações pedagógicas cujas reflexões venham a fortalecer lutas por uma educação pública emancipatória. Sustentamos a necessidade de incluir nas ações pedagógicas da formação de professores temáticas referentes à valorização da nossa profissão.
Evaluation of sustainability development of the eco-economic system of water and soil resources based on emergy analysis
Authors: Zhang Wenfang , Wu Zening , Guo Xi , Jiang Mengmeng , Yan Denghua
Published: January 2024

Due to the swift progress of the economy and society and the rapid escalation of urbanization rates, the sustainable examination of individual water or land resources is no longer adequate to satisfy the rational allocation demands of urban development concerning the water and soil resource framework. To enhance the efficiency of utilizing water and land resources comprehensively and the rationality of the joint allocation of these resources, this paper presents a comprehensive analysis of the eco-economic system of water and land resources, encompassing six key aspects: system emergy flow, water resources subsystem, land resources subsystem, economic subsystem, ecological subsystem, and social subsystem. By considering three types of land use (construction land, agricultural land, and unused land), we constructed a sustainable evaluation index system for the eco-economic system of water and land resources based on the emergy theory. We employ the emergy theory analysis method to provide a comprehensive assessment of the sustainable development status and development trend of the Luoyang City from 2011 to 2020. The results show that Luoyang belongs to the consumer economy and the development of water and soil resources of the ecological economic system in Luoyang is in a critical state of unsustainable and mild sustainability from 2011 to 2020.
“It has to be better, otherwise we will get stuck.” A Review of Novel Directions for Mental Health Reform and Introducing Pilot Work in the Netherlands
Authors: van Os Jim , Scheepers Floortje , Milo Michael , Ockeloen Gijs , Guloksuz Sinan , Delespaul Philippe
Published: January 2024

Background:

The current state of mental health care in the Netherlands faces challenges such as fragmentation, inequality, inaccessibility, and a narrow specialist focus on individual diagnosis and symptom reduction.

Methods:

A review suggests that in order to address these challenges, an integrated public health approach to mental health care that encompasses the broader social, cultural, and existential context of mental distress is required.

Results:

A Mental Health Ecosystem social trial seeks to pilot such an approach in the Netherlands, focusing on empowering patients and promoting collaboration among various healthcare providers, social care organizations, and peer-support community organizations, working together in a regional ecosystem of care and committed to a set of shared values. In the ecosystem, mental health problems are examined through the prism of mental variation in context whilst scaling up the capacity of group-based treatment and introducing a flexible and modular approach of (2nd order) treatment by specialists across the ecosystem. The approach is to empower naturally available resources in the community beyond professionally run care facilities. Digital platforms such as psychosenet.nl and proud2bme.nl, which complement traditional mental health care services and enhance public mental health, will be expanded. The capacity of recovery colleges will be increased, forming a national network covering the entire country. GEM will be evaluated using a population-based approach, encompassing a broad range of small-area indicators related to mental health care consumption, social predictors, and clinical outcomes. The success of GEM relies heavily on bottom-up development backed by stakeholder involvement, including insurers and policy-making institutions, and cocreation.

Conclusion:

By embracing a social trial and leveraging digital platforms, the Dutch mental health care system can overcome challenges and provide more equitable, accessible, and high-quality care to individuals.
Degradation of Aflatoxin M1 by Lipase and Protease in Buffer Solution and Yoghurt
Authors: El-desouky Tarek A. , Kholif Adel. M. M.
Published: January 2024

Objective:

This study aimed to examine the effectiveness of lipase and protease obtained from bacteria in the degradation of aflatoxin M1 (AFM1) in phosphate-buffered saline (PBS) and during the production of yoghurt.

Methods:

In this study, two strains, Levilactobacillus brevis and Lactobacillus plantarum, were used to produce protease and lipase, respectively. We then investigated the ability of protease and lipase to degrade AFM1 at four concentrations (50, 100, 150, and 200 U/ml for each enzyme) in vitro and during the preparation of yoghurt.

Results:

The results revealed that the highest activity was recorded at pH 7 and 7.5 for protease and lipase, respectively. As well, the optimum activity was observed at temperatures of 50 °C and 30 °C for protease and lipase, respectively. In vitro, the lipase enzyme at 200 U/ml degraded the AFM1 to 31.8, 37.4, and 56.7%, after incubating the PBS for 6, 12, and 18 h, respectively. Concerning protease, the means of degradation for AFM1 were 35.03, 43.7, and 72.9%, under the same conditions in yoghurt made from samples contaminated with 10 μg/L of AFM1, which was treated by both lipase and protease enzymes at 0.3, 0.6, and 0.9%, respectively. In yoghurt made from contaminated milk at 10 μg/L for AFM1, which was treated by 0.3, 0.6, and 0.9% of both lipase and protease, after two days of storage, the means of degradation of AFM1 were 23.4, 37.8, and 65.9%, respectively, which increased after five days to 27.3, 52.6, and 78.5%, respectively.

Conclusion:

Degradation of AFM1 was examined during the manufacturing of yoghurt using both bacterial lipase and protease without significantly affecting the sensory qualities of the finished product. Because of this, these enzymes could be a useful option in the biotech and dairy industries.
„Greater arc injuries” - irodalmi áttekintés egy saját eset bemutatása kapcsán
Authors: Péterfy Nóra , Hetthéssy Judit Réka
Published: January 2024

A töréssel járó perilunaris ficamok ritka sérülések, azonban a legkörültekintőbb sebészi ellátás és megfelelően vezetett utókezelés mellett is nehéz jó eredményeket elérni. „Greater arc injuries” azon komplex töréssel járó perilunaris ficamok összessége, ahol a szalagsérülés mellett az os lunatum körüli kéztőcsontok, illetve adott esetben a radius törése is bekövetkezik, ezáltal komplexen sérül a csukló biomechanikája. Tekintettel azonban arra, hogy ezek a sérülések a fiatal, munkában és sportban aktív populációt érintik, a kezelés célja a csukló biomechanikájának helyreállítása, úgy, hogy a terhelhetőség és a mozgástartomány visszaszerzése mellett ne maradjanak vissza prearthrotikus elemek. A szerzők közleményükben ismertetik a sérülés etiológiáját, előfordulási gyakoriságát, főbb diagnosztikus (röntgen és CT) jeleit, sebészi ellátását, a rögzítés és utókezelési technikáit, és egy 24 éves férfibeteg esetbemutatása mellett ismertetik – a mindennapi ellátása kapcsán tárgyalják – az ellátási folyamat kérdéses, illetve optimalizálható pontjait.
The key factors impacting on ccience communication effects in the WeChat official accounts: A theoretical framework of risk-benefit perceptions
Authors: Niu Panqiang , Masduki Anang , Tu Caixie , Efiyana Maria , Jian Liu
Published: January 2024

By adopting the theoretical framework of Risk-Benefit perceptions, this study takes the popularization of Artificial Intelligence (AI) knowledge as an empirical object to test the key factors impacting on science communication effects in the WeChat official accounts. Results showed that science communication uncertainty produced both direct and indirect effects on science communication effects. The indirect effect was mainly mediated by perceived risk. Public trust negatively moderated the association between perceived uncertainty and perceived risk at a low trust level. Perceived entertainment had a positive effect on science communication effects in the benefit-perception perspective.
Neutrophil-to-Lymphocyte Ratio Predicts Immune-related Adverse Events in Patients With Hepatocellular Carcinoma Treated With Atezolizumab Plus Bevacizumab
Authors: KUWANO AKIFUMI , YADA MASAYOSHI , TANAKA KOSUKE , KOGA YUTA , NAGASAWA SHIGEHIRO , MASUMOTO AKIHIDE , MOTOMURA KENTA
Published: January 2024

Background/Aim: Atezolizumab in combination with bevacizumab is an approved systemic chemotherapy regimen for advanced hepatocellular carcinoma (HCC). However, immune checkpoint inhibitors (ICIs), such as atezolizumab, frequently lead to immune-related adverse events (irAEs). The identification of biomarkers that can predict the occurrence of irAEs is crucial for the optimal management of patients undergoing ICI treatment. Patients and Methods: Between October 2020 and June 2023, we conducted a study involving 69 patients with advanced HCC who received treatment with atezolizumab plus bevacizumab. We conducted an analysis of blood-based biomarkers to identify independent risk factors associated with irAEs. Results: In our study, 12 out of 69 patients (17.4%) experienced irAEs. Our investigation into blood-based biomarkers revealed that a neutrophil–to-lymphocyte ratio (NLR) <2.04 at three weeks after the initiation of treatment had high predictive power (area under the curve: 0.77) for irAEs. Furthermore, multivariate logistic analysis identified NLR at three weeks (hazard ratio=0.23; p=0.037) and non-viral infection (hazard ratio=4.47; p=0.037) as independent factors contributing to the occurrence of irAEs. Patients who developed irAEs demonstrated a more favorable overall response rate (75.0% vs. 28.1%, p=0.005), disease control rate (91.6% vs. 52.6%, p=0.016), and progression-free survival (12.1 months vs. 6.0 months, p=0.010) than those who did not experience irAEs. Conclusion: An NLR <2.04 at three weeks after the initiation of treatment may serve as a valuable biomarker for predicting irAEs in patients with HCC undergoing atezolizumab plus bevacizumab therapy.
Survival Following Palliative Radiotherapy for Head and Neck Squamous Cell Carcinoma: Examining Treatment Indications in Elderly Patients
Authors: KATANO ATSUTO , MINAMITANI MASANARI , TONGYU GAO , OHIRA SHINGO , YAMASHITA HIDEOMI
Published: January 2024

Background/Aim: This study investigated the survival outcomes of patients with head and neck squamous cell carcinoma (HNSCC) undergoing palliative radiotherapy, particularly focusing on challenges and factors associated with older age, providing insights into appropriate palliative radiotherapy use in this demographic. Patients and Methods: A retrospective study was conducted using electronic medical records of 73 patients with HNSCC who were deemed unsuitable for curative therapy. Palliative radiotherapy involved a uniform dose of 30 Gy in 10 fractions. Survival analysis was performed using Kaplan–Meier method, and multivariate analysis identified significant prognostic factors. Results: The median overall survival was 7.5 months, with no significant difference between age groups. Karnofsky performance status (KPS) >70 correlated with favorable survival. Multivariate analysis confirmed KPS as an independent prognostic factor (hazard ratio=1.949, p=0.031). Conclusion: The results of this study align with those of previous studies, emphasizing the importance of palliative radiotherapy for HNSCC treatment. Optimal dose fractionation regimens remain undetermined, and tailored approaches that consider factors, such as age and performance status are crucial. Individualized, comprehensive assessments and supportive care measures enhance patient well-being, reflecting palliative care principles.
Significance of Preoperative Tooth Loss in Patients Who Underwent Gastrectomy for Gastric Cancer
Authors: AZUMI YUKI , KANAJI SHINGO , SAWADA RYUICHIRO , HARADA HITOSHI , URAKAWA NAOKI , GOTO HIRONOBU , HASEGAWA HIROSHI , YAMASHITA KIMIHIRO , MATSUDA TAKERU , OSHIKIRI TARO , KAKEJI YOSHIHIRO
Published: January 2024

Background/Aim: The relationship between gastric cancer and oral health has been reported in several studies. This study aimed to determine the relationship between the postoperative prognosis of gastric cancer and oral health using preoperative tooth loss as a simple index. Patients and Methods: We conducted a single-center retrospective cohort study. Patients were divided into two groups according to the number of tooth losses. The survival curve was constructed using the Kaplan–Meier method. We also performed univariate and multivariate analyses of overall survival based on Cox proportional hazard regression to determine prognostic factors. Results: A total of 191 patients were divided into two groups: those with seven or more tooth losses and those with less than seven tooth losses. The three-year overall survival rate was 71.5% in the group with seven or more tooth losses and 87.0% in the group with less than seven tooth losses. The group with seven or more tooth losses had a significantly lower overall survival rate compared to the group with less than seven tooth losses (p=0.0014). However, in multivariate analysis, tooth loss was not identified as an independent prognostic factor whereas age, clinical T stage, CEA level, and serum albumin level were independent poor prognostic factors. Conclusion: Preoperative tooth loss was not a prognostic factor for gastric cancer after gastrectomy, but tooth loss may be a simple and useful method for evaluating frailty in patients.
Two Cases of Emergency Tracheostomy After Head and Neck Photoimmunotherapy
Authors: OKAMOTO ISAKU , OKADA TAKURO , TOKASHIKI KUNIHIKO , TSUKAHARA KIYOAKI
Published: January 2024

Background/Aim: Head and neck photoimmuno-therapy (HN-PIT) has been an insured treatment in Japan for approximately three years. The number of treatments has gradually increased to over 350 cases. However, there are still various questions in actual clinical practice, including laryngeal edema. Therefore, it is vital to carefully explain in advance to patients the possibility of laryngeal edema occurring and obtaining consent for tracheostomy as a prophylactic or emergency measure. At our institution, 44 HN-PIT cycles were performed in 23 patients between January 2021 and October 2023. Of these, we experienced two cases in which preventive tracheostomy was not performed because the risk of laryngeal edema was considered low; however, laryngeal edema developed after treatment, and an emergency tracheostomy had to be performed. Case Report: Case 1 was a patient in his 70s with a local recurrence of mandibular gingival carcinoma. HN-PIT using cylindrical diffusers was performed on the target lesion, extending from the lateral wall of the oropharynx to the soft palate. Case 2 was also a patient in his 70s with carcinoma of the mid-pharynx. HN-PIT was performed using a frontal diffuser to target lesions extending from the soft palate to the buccal mucosa. Notably, both patients developed laryngeal edema after HN-PIT, and an emergency tracheostomy had to be performed. Conclusion: HN-PIT treatment is still being established through a trial-and-error method and is still incomplete.
Design and Implementation of an Inpatient Fall Risk Management Information System (Preprint)
Authors: Wang Ying , Jiang Mengyao , He Mei , Du Meijie
Published: January 2024

BACKGROUND

Falls had been identified as one of the nursing-sensitive indicators for nursing care in hospitals. With technological progress, health information systems make it possible for health care professionals to manage patient care better. However, there is a dearth of research on health information systems used to manage inpatient falls.

OBJECTIVE

This study aimed to design and implement a novel hospital-based fall risk management information system (FRMIS) to prevent inpatient falls and improve nursing quality.

METHODS

This implementation was conducted at a large academic medical center in central China. We established a nurse-led multidisciplinary fall prevention team in January 2016. The hospital’s fall risk management problems were summarized by interviewing fall-related stakeholders, observing fall prevention workflow and post–fall care process, and investigating patients' satisfaction. The FRMIS was developed using an iterative design process, involving collaboration among health care professionals, software developers, and system architects. We used process indicators and outcome indicators to evaluate the implementation effect.

RESULTS

The FRMIS includes a fall risk assessment platform, a fall risk warning platform, a fall preventive strategies platform, fall incident reporting, and a tracking improvement platform. Since the implementation of the FRMIS, the inpatient fall rate was significantly lower than that before implementation (P<.05). In addition, the percentage of major fall-related injuries was significantly lower than that before implementation. The implementation rate of fall-related process indicators and the reporting rate of high risk of falls were significantly different before and after system implementation (P<.05).

CONCLUSIONS

The FRMIS provides support to nursing staff in preventing falls among hospitalized patients while facilitating process control for nursing managers.
Development of Cascara Tisane with The Addition of Dried Pineapple (Ananas sativus) and Rosella Flower (Hibiscus sabdariffa)
Authors: Wardhany Dinda , Fajar Falah Mohammad Affan
Published: January 2024

Coffee cherry skin, a form of coffee production waste that accounts for up to 60% of the total yield, contains natural antioxidants that have the potential to become functional foods. Cascara Tisane is a brewed beverage derived from dried coffee cherry skin. Adding other ingredients to this product can help increase consumer acceptance in Indonesia. In this study, the additional ingredients used were dried pineapple and rosella flowers. To determine the effect of adding these ingredients, it is necessary to identify the drying temperature and chemical and organoleptic characteristics to produce Cascara Tisane products according to the Indonesian National Standard (SNI). The research consisted of two stages, namely (1) the identification of the drying temperature of coffee cherry skin and (2) the formulation of the addition of dried pineapple and rosella. The drying temperatures used were 45 oC, 50 oC, 55 oC, and 60 oC. The sample formulation consists of four levels, namely code 126 (75% coffee cherry skin, 15% dried pineapple, 10% rosella): 216 (65% coffee cherry skin, 20% dried pineapple, 15% rosella); and 616 (55% coffee cherry skin, 25% dried pineapple, 20% rosella). Chemical characteristics analysis was conducted on moisture and ash contents, as well as antioxidant activity. Furthermore, a hedonic test was used to evaluate cascara tisane products' organoleptic characteristics (aroma, taste, color, and aftertaste) with a 5-point hedonic scale. The results showed the optimum drying temperature of coffee cherry skin at 45 oC, with the most preferred formula being formula 616.
Effect of Adding Carrageenan Processing Solid Waste from Eucheuma cottonii to Art Paper Manufacture from Water Hyacinth
Authors: Paramitha Almira , Dewi Eko Nurcahya , Kurniasih Retno Ayu
Published: January 2024

The carrageenan industry produces solid waste E. cottonii of 65% to 70%, so it had the potential to be used as a paper material. The aimed of this study was to analyze the effect of the concentration of E. cottonii waste which was added in the production of art paper from water hyacinth stems on the quality of the paper. The experimental design used was Complete Randomized Design with 1 factor, namely the difference of Eucheuma cottonii waste concentration (0%, 10%, 15%, and 20% (w/w)). The results showed that the addition of carrageenan processing from E. cottonii with difference concentration gave significantly different (p<0.05) on the value of grammage, tensile strength, tear resistance, density, and lightness of the paper. The best concentration of Eucheuma cottonii was 15% because it had the highest tear resistance value (p<0.05) and higher of lightness than the concentration of 0% and 10% (p<0.05). Paper with waste E. cottonii 15% had a grammage 148.93 g/m2; tensile resistance 1.28 kN/m; tear resistance 2497.37 mN; density 1.52 g/cm3; and lightness L* 80.19. The results of microstructure observations using Scanning Electron Microscopy (SEM) were the paper with E. cottonii waste 15% seen less free space (tighter) than other papers. Based on the grammage and tensile resistance value, paper with E. cottonii waste 10% according to Indonesian National Standard 8218:2015 regarding paper and cardboard for food packaging requirements.
Analysis of Carbon Sequestration Rate in Seaweed (Kappaphycus alvarezii) Based on Environmental Mitigation
Authors: Sahir Muhammad , Riskiani Isma , Dewi Uttari , Yusuf Muhammad Yusfi
Published: January 2024

Blue economy is a development concept that develops by relying on marine or aquatic resources. An increase in carbon dioxide (CO2) in the atmosphere is fueling climate change. This study aims to analyze the rate of carbon uptake in the waters, using seaweed Kappaphycus alvarezii which utilizes carbon to be converted into biomass before returning to the air. The results showed that highest carbon absorption rate was found in location A with the highest total carbon absorption of 94.87±0.77 tons C/planting cycle, then treatment B with 83.96±0.54 tons C/planting cycle, and the lowest in treatment C with 76.88±0.18 tons C/planting cycle. Water quality parameters are still mostly in decent condition for the cultivation of Kappaphycus alvarezii seaweed. Salinity conditions of waters are relatively high (35-39 ppt) even though the optimum seaweed grows in the range of 30-34 ppt. The conclusion of the study is that the highest total carbon is found at Location A, which is 94.87±0.77 tons C/planting cycle. The suggestion of this study is that it is necessary to analyze the suitability of seaweed cultivation land with various water quality parameters, so that mapping of potential types of seaweed that can be cultivated according to the characteristics and quality of the waters.
RELATIONSHIP BETWEEN GENDER, STUDY DURATION AND BURNOUT AMONG MEDICAL STUDENTS
Authors: Zulfan Zulfan , Pamungkasari Eti Poncorini , Maryani Maryani
Published: January 2024

Background: Burnout is a psychological syndrome as a response that arises due to chronic interpersonal stressors at work. Burnout in medical students has a negative impact mentally and physically.Aims: This study aims to determine the relationship between gender and study duration with burnout in medical students.Method: This study was conducted using an analytical observational method with a cross-sectional study approach using MBI-SS. The population for this study is composed of medical students at the Faculty of Medicine at Universitas Sebelas Maret, specifically those from the classes of 2019-2021. Samples were selected randomly using a stratified random sampling method. The sample size was 247 students. The data were then analyzed using SPSS 22 for Windows.Result: The results of the analysis showed that there was no significant difference in the level of burnout based on gender with p-value of 0.786, but there was a significant difference in the level of burnout based on the study duration with p-value of 0.044, which the third-year students rank highest in MBI-SS score.Conclusion: The results of this study indicate that there is no significant relationship between gender and burnout levels but there is a significant relationship between study period and burnout levels. These results indicate that the longer the study duration, the higher the burnout level of students.
Efektivitas Organisasi Perangkat Daerah dalam Pengelolaan Aset Kota: Studi Badan Keuangan Daerah Kota Depok
Authors: Firdausy Balqis Mira , Lutfi Achmad
Published: January 2024

Tulisan ini mengevaluasi efektivitas Badan Keuangan Daerah (BKD) Kota Depok dalam pengelolaan aset kota. Melalui pendekatan kualitatif, data dikumpulkan melalui wawancara, observasi, dan analisis dokumen terkait. Tulisan ini menemukan bahwa BKD telah melakukan upaya dalam pengelolaan aset kota, namun masih menghadapi kendala. Kurangnya koordinasi antara OPD terkait, rendahnya pemahaman akan pentingnya pengelolaan aset, dan keterbatasan sumber daya manusia juga teknologi memengaruhi efektivitasnya. Dalam meningkatkan pengelolaan aset kota, diperlukan peningkatan koordinasi, pemahaman, dan kesadaran tentang pentingnya pengelolaan aset, serta peningkatan sumber daya manusia dan teknologi. Tulisan ini memberikan kontribusi dalam pemahaman tentang efektivitas pengelolaan aset kota oleh BKD. Tulisan ini diharapkan dapat membantu pemerintah daerah meningkatkan pengelolaan aset kota yang lebih efektif dan efisien, memberikan manfaat optimal bagi masyarakat Kota Depok.
Mempertahankan Kekuasaan: Dinamika di Balik Status Quo Privatisasi Air di DKI Jakarta
Authors: Syah Putra Rewinata
Published: January 2024

Tulisan ini menganalisis bagaimana kekuasaan diorganisir dan digunakan untuk mempertahankan status quo atas kewenangan melakukan privatisasi air. Meminjam teori tentang struktur kekuasaan Susan Strange, artikel ini berusaha menjelaskan bagaimana bekerjanya struktur produksi dan struktur pengetahuan yang dibangun oleh PT Aetra dan PT Palyja untuk mempertahankan posisi mereka menggunakan kasus privatisasi air. Studi ini menemukan bahwa PKS PAM JAYA merupakan wujud dari penggunaan struktur produksi dan gagasan komodifikasi air merupakan wujud dari penggunaan struktur pengetahuan sebagai instrumen untuk mempertahankan dominasi dan kewenangan atas privatisasi air di DKI Jakarta. Adapun kajian dalam tulisan ini bertujuan untuk mendeskripsikan tentang dinamika atas privatisasi air di Jakarta dan kemungkinan implikasinya, baik secara ekonomi dan sosial. Tulisan ini menggunakan data-data sekunder di dalam membangun argumentasi atas strategi yang digunakan PT Aetra dan PT Palyja untuk mengorganisir kuasa guna mempertahankan status quo. Data-data yang digunakan berupa laporan-laporan tertulis yang ada kaitannya dengan masalah privatisasi air, baik berupa kebijakan internasional, nasional, termasuk terkait aturan pemerintah daerah, surat-surat resmi kerja sama, jurnal atau literatur yang relevan dan penelusuran perkembangan informasi tentang privatisasi air berbasis website.
Analisa Aktor dalam Aktivitas Penambangan Timah Ilegal di Kabupaten Belitung Timur
Authors: Ristiandy Risky
Published: January 2024

Tulisan ini menganalisis aktor dan perannya dalam relasi hubungan antar aktor pada aktivitas penambangan timah ilegal di Kabupaten Belitung Timur. Hal ini dilakukan karena aktor-aktor yang selama ini diketahui merupakan aktor utama adalah kalangan penambang dan jarang terungkap aktor lain yang menyebabkan kegiatan ilegal ini terus beroperasi. Selain itu, artikel ini juga melihat bagaimana aktor dan jejaringnya bekerja dan menyebabkan permasalahan penambangan timah ilegal di Kabupaten Belitung Timur terjadi dan tidak terselesaikan sampai saat ini. Pendekatan yang digunakan dalam tulisan ini adalah pendekatan kualitatif, dengan menggunakan metode stakeholder analysis dan metode analisis interaktif yang telah dilakukan pada rentang waktu Juni 2022-Januari 2023. Hasil analisis menunjukkan bahwasanya aktivitas penambangan timah ilegal di Kabupaten Belitung Timur terus berlanjut disebabkan oleh aktor yang mendukung dan menyediakan sarana juga jalur penjualan. Selain itu, relasi antar aktor yang membuat sebuah jaringan yang saling tergantung menyebabkan praktik penambangan timah ilegal tetap berlangsung. Aktor yang terlibat dalam relasi penambangan timah ilegal di Kabupaten Belitung Timur meliputi aktor negara, aktor utama (masyarakat), dan aktor pendukung (swasta).