bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrazides as Potential HDAC Inhibitors: Structure-activity
Relationships and Biological Implications
Authors: Banerjee Suvankar , Baidya Sandip Kumar , Adhikari Nilanjan , Jha Tarun , Ghosh Balaram
Published: April 2023

Epigenetic modulations by HDACs are associated with multiple disease conditions. In this context, HDACs play vital roles in the progression of diseases including several cancers, neu-rodegenerative diseases, inflammatory diseases, and metabolic disorders. Though several HDAC inhibitors have been established as drug candidates, their usage has been restricted because of broad-spectrum inhibition, highly toxic character, and off-target adverse effects. Therefore, specific HDAC selectivity is essential to get rid of such adverse effects. Hydrazide-based compounds have already been proven to exert higher inhibitory efficacy and specific HDAC selectivity. In this arti-cle, the detailed structure-activity relationship (SAR) of the existing hydrazide-based HDAC inhibi-tors has been elucidated to gather crucial information that can be utilized further for the develop-ment of promising drug candidates for combating diverse diseases in the future.
Endometriosis Reccurence – is Ultrasound the Solution?
Authors: Mihai Malutan Andrei , Nati Ionel-Daniel , Ciortea Razvan , Bucuri Carmen , Patricia Rada Maria , Mihaela Ormindean Cristina , Mihu Dan
Published: April 2023

Background:

Transvaginal and transabdominal ultrasonography has become a widely used investigative method in the diagnostic workup of endometriosis, as well as for the postoperative follow-up. The variety of lesions, the distorted anatomy caused by adhesions and the fibrosis process represent the main challenges of the ultrasound evaluation. Regarding the recurrence of endometriosis, the diagnostic criteria are being imprecise, being adjusted according to the development of ultrasound techniques.

Objective and Methods:

To this study, extensive research has been performed interrogating PubMed, Embase and Web of Science databases to identify published research including patients with endometriosis who underwent surgery. Included patients had postoperative ultrasound investigations to detect evidence of endometriosis recurrence. The selected timeframe was 5 years. We conducted a literature review on ultrasound markers of endometriosis recurrence.

Results:

In this analysis, 2023 patients from 9 studies were included. The recurrence rate detected was 17.26%. The postoperative treatment was different in the selected studies and they include the administration of progesterone, oral combined contraceptives, GnRh antagonists, aromatase inhibitors and intrauterine devices with prolonged release of progesterone.

Discussion:

The recurrence rate is different in the selected studies as a result of the recurrence definition used by each author and the minimum dimension of the lesions, in case of the cystic pattern. Innovative techniques of differential diagnosis by ultrasound are proposed, one of them being the textural analysis performed by computer-aided diagnosis – CAD. In order to standardize the recommendations regarding imaging techniques, we propose an algorithm for following up with patients in the postoperative period.

Conclusion:

The transabdominal or endovaginal ultrasound performed regularly represents a key factor to determine the recurrence of endometriosis in the postoperative period and the imaging reassessment is recommended to be performed at a 6-month interval.
Radiographic and Ultrasonographic Evaluation of the Rare Sesamoid Bone of
the Elbow: Os Subepicondylare Mediale
Authors: Doğan Yahya
Published: April 2023

Background:

Sesamoids and accessory bones are generally small-sized and oval-shaped structures whose function and pathology are not fully elucidated. Despite their small size, sesamoid bones can directly or indirectly cause diagnostic problems. Sesamoid bones are less common in the elbow region and may need to be differentiated from a lot of diagnoses such as fractures, osteochondritis dissecans, calcific tendinitis, and synovial chondromatosis.

Case presentation:

A 55-year-old female patient presented with right elbow pain. An oval mass was seen near the medial epicondyle on the radiograph. A dynamic ultrasound examination was performed to reveal the relationship between the bone mass and the surrounding tissues, especially the ulnar nerve. Due to the well-circumscribed mass, a diagnosis of os subepicodlare mediale, a rare sesamoid bone, was made in light of current literature.

Conclusions:

When a bone mass is seen in patients presenting with elbow pain, it will be useful to know and consider the sesamoid bones. In addition, ultrasonography should be performed in addition to radiography for a localized sesamoid bone in the medial region and adjacent to the ulnar nerve. Thus, the relationship of the sesamoid bone with existing and potential complaints can be revealed and correct diagnosis-treatment approaches can be applied.
GPR18 and GPR55-related Ligands Serving as Antagonists or Agonists:
Current Situation, Challenges and Perspectives
Authors: Zhang Linjie , Fang Yiwen , Hang Sijing , Wu Wenhui , Sheng Ruilong , Guo Ruihua
Published: April 2023

GPCR superfamily, the largest known family of membrane receptors, consists of six
classes from A to F. GPR18 and GPR55, δ-branch of A class, had been reported to have no confirmed
endogenous ligand and were named as “orphan receptors”. Previous studies suggest that both
GPR18 and GPR55 are possibly related to the migration and proliferation of cancer cells, macrophages
and other inflammation-associated immune cells. Thus, they may be potential targets for inflammation,
cancer and analgesia therapy. In this paper, we aimed to summarize the chemical structures
and bioactivities of the agonists and antagonists of GPR18 and GPR55; moreover, we have
briefly discussed the challenges and future perspectives in this field. This review will be beneficial
for further design and synthesis of efficient agonists and antagonists towards GPR18 and GPR55-
related disease treatment.
Non-ANCA Leucocytoclasic Vasculitis Induced by Sofosbuvir/Ledipasvir
Treatment: A Case Report
Authors: Zaimi Yosra , Ayari Myriam , Ghithia Nadine , Ayadi Shema
Published: April 2023

Background:

The development of direct-acting antivirals directed against the Hepatitis
C Virus has dramatically modified the therapeutic approach to chronic hepatic viral disease. Larger
use of such drugs has also led to increasing reports about their adverse effects. This report aimed to
describe a case of leucocytoclasic vasculitis following treatment based on the sofosbuvir/ledipasvir
regimen with complete disappearance shortly after withdrawal in a 61-year-old patient treated for
genotype 1 hepatitis C.

Case Presentation:

A 61-year-old Tunisian woman with a history of hepatitis C virus genotype 1
infection developed palpable purpura in front of low extremity articulation, five weeks after the
onset of sofosbuvir/Ledipasvir. The histological examination concluded with leucocytoclasic vasculitis,
with total disappearance three days after withdrawal. The pre-therapeutic assessment
showed no positivity of Cryoglobulinemia. Anti-neutrophil cytoplasmic antibodies (ANCA) were
negative. A sustained viral response was obtained only 5 weeks after treatment without an increase
of viral load during follow-up.

Conclusion:

There was a temporal relationship between antiviral treatment and non-ANCA skin
vasculitis. The pharmacological department concluded the imputability of antiviral treatment
(score I2B2).
Immunological Facet and Inception after Post-COVID-19 Vaccination
Authors: Ray Suman Kumar , Mukherjee Sukhes
Published: April 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced coronavirus disease
2019 (COVID-19) pandemic has produced an unparalleled setback for the world's economy and
health. One of the best therapies to significantly lower severe illness and mortality from SARS-CoV-2
infection is vaccination. Worldwide vaccination campaigns are being implemented. New-onset autoimmune
problems, such as immune thrombotic thrombocytopenia, autoimmune liver disorders, IgA
nephropathy, Guillain-Barré syndrome, systemic lupus erythematosus, and rheumatoid arthritis, have
recently been described more frequently after receiving COVID-19 vaccine. The creation of specific
autoantibodies, molecular mimicry, and the function of specific vaccine adjuvants all emerge to play a
significant role in autoimmunity. The post-acute sequelae of SARS-CoV-2, usually known as Long
Covid Syndrome, are beginning to be better understood in terms of the disparities in immune responses
seen in individuals with and without the condition. We anticipate that the knowledge gleaned from
several COVID-19 investigations will be put to use in research on the inflammatory mechanisms implicated
in serious and protracted illnesses, which is still a key unmet need.
An Effective Mechanism to Mitigate Packet Dropping Attack from
MANETs using Chaotic Map based Authentication Technique
Authors: Ahmed C. Atheeq , C. Altaf , Mohammad Mohammad , Mohammed Aleem
Published: April 2023

Background:

MANET is a self-organized wireless network with no infrastructure. Especially
data transfer from one system to another system needs to be done in a secure way. In order
to provide data integrity, authentication plays an important role in data communication. RSA
and ECC are widely used algorithms in the real world, but authentication using these algorithms is
time-consuming. Towards this, various algorithms came into existence with different security
primitives. However, it is important to design an effective key agreement process with reduced
computational cost among these security mechanisms. We have designed an effective mechanism
to mitigate packet dropping attacks to secure end-to-end communication in MANET.

Objective:

The proposed light weight authentication method is based on chaotic maps that uses
Chebyshev polynomials as primitive operation.

Methods:

The methodology includes semi group property of Chebyshev polynomials and also the
discrete logarithmic problem based chaotic maps that takes less time than these existing algorithms
and evaluates with respect to attack Resilience, packet deliverya fraction, delay, throughput,
and overhead.

Results:

Simulation produces the result of the proposed mechanism and give better performance
in terms of packet delivery ratio, overhead and computational cost.

Conclusion:

Authentication based on developed mechanism consumes less time as shown in statistical
analysis and mitigates packet dropping attacks effectively than that of traditional methods
like RSA and ECC with respect to key generation mechanism.
Universidad sostenible o universidad ecológica. Los retos de la educación superior frente a la crisis ambiental
Authors: Fernández Mora Vicente de Jesús
Published: April 2023

El texto presenta algunos apuntes acerca de la evolución reciente de la universidad y las crisis que enfrenta ante los retos que plantean a la institución la desregulación mundial de los servicios educativos, las presiones sociales democratizadoras y las demandas de una reforma que esté a la altura de la actual crisis ambiental que sufre el planeta. Dicha reforma puede ser entendida desde el enfoque de la sostenibilidad, que perpetúa los modelos de educación y subjetividad hegemónicos, o desde una reforma epistemológica e institucional verdaderamente ecológica y emancipadora.
A Study on Interest Factors of Kimwonjeon: Focused on the Characters and Establishing Their Worldview
Authors:   Korean Language & Literature, Yoon Bo-yoon
Published: April 2023

Kimwonjeon is a story of a protagonist, Kim Won, who wins the confrontation with the evil character through his extraordinary ability and the help of a supporting character and ends up in an amicable relationship with the two female characters. This story organically structured the plot by arranging various types of characters rather than simply enumerating the motifs. It implies that the interest factors of tales familiar to the readership are developed into novelistic features. Firstly, the protagonist was embodied by inheriting the narrative tradition of heroic characters. The story structure of a hero's journey whose life undergoes trials at a young age but escapes from the crisis with helpers and achieves something great based on his outstanding abilities. Kim Won's oviparity and conquest were used to enhance his heroism. Secondly, the antagonist in the story was put into a process called characterization to create an adversary of the protagonist. What draws readers' attention is the enormous appearance and power of the monster and the detailedly described underworld while simultaneously arousing curiosity about how Kim Won would defeat such a strong presence. The stunning portrayal of the antagonist is to embody the protagonist's activities against it in a more exciting way. Thirdly, female characters in the story play a role in making the narrative more vivid. The princess contributes to exterminating the monster, devotes herself to Kim Won, and supports her parents-in-law. The princess of the Sea God even leaves her hometown at Kim Won's request and plays a significant role in reviving him. In this way, the two female characters, the princess and the princess of the Sea God, are actively involved in making the story more interesting. By embracing narrative elements into the classic novel, Kimwonjeon established a worldview that readers would be enthusiastic about. The protagonist who descended from the celestial realm defends the ideology of loyalty, filial piety, and fidelity in the process of performing heroic activities in unique spaces such as the underground world and the underwater world, and returning to the earthly world to enjoy wealth and glory. The Confucian perspective was set up so that the protagonist and female characters protect it, naturally pleasing readers' desires.
Greater Objective and Perceived Competence for Clinics is Associated with Reduced Stress but No Change in Impostorism in Medical Students <a class="tippyShow" data-tippy-arrow="true" data-tippy-content="A portion of this work was published in abstract form and presented at the 25th annual meeting of the International Association of Medical Science Educators, June 12-17, 2021 [1]" data-tippy-interactive="true" data-tippy-theme="light-border" style="cursor:pointer">a
Authors: Levant Beth , Nguyen Emma , Villwock Jennifer A. , Manzardo Ann M.
Published: April 2023

Impostorism is prevalent in medical students and negatively impacts wellness, contributing to stress and burnout. Perceived competence is noted as one attribute underlying impostorism. A curricular change that resulted in improved United States Medical Licensing Examination (USMLE) Step 1 scores and student self-perceptions of preparedness for clinical training was used as a natural experiment to assess the effects higher competence/preparedness, based on an objective indicator and self-perceptions, on impostorism, stress, and burnout during early clinical training. Third-year medical students in the last class of the old “Legacy” curriculum and the first class of the revised “ACE” curriculum completed a voluntary, anonymous survey that included the Clance Impostor Phenomenon Scale, the Perceived Stress Scale, and the abbreviated Maslach Burnout Assessment. USLME Step 1 scores and data on students’ self-perception of their preparedness for clinics were collected as part of routine curricular monitoring. Both groups of students had highly similar entering demographics. Compared to Legacy students, ACE students had higher USMLE Step 1 scores (p < 0.001) and perceived themselves to be better prepared for clinical clerkships (p < 0.001). Stress scores were 15% lower in ACE students (p < 0.05). However, impostor scores were nearly identical between these groups and the proportions of students endorsing burnout were not different. This suggests that impostorism and burnout during the transition to clinical training are not attenuated by improved competence and are not directly related to stress.
Cytotoxic potential activity of quercetin derivatives on MCF-7 breast cancer cell line
Authors: Salman Jasim Husam , Al-kubaisi Zainab A. , Al-Shmgani Hanady S.
Published: April 2023

Many previous investigations have found quercetin to be a powerful antioxidant and antitumor flavonoid, but its poor bioavailability has limited its use. This current study investigated the effects of two newly synthesized Quercetin Schiff bases containing 2-amino thiadiazole-5-thiol (Q1), and its benzyl derivatives (Q2) on MCF-7 human breast cancer cells. Cell viability and apoptosis were assessed to determine the toxic effects of Q1 and Q2. Cytotoxicity valuation showed that both compounds inhibited MCF-7 cell growth, and lactate dehydrogenase (LDH) activity increased in a dose-dependent aspect compared to the control group. Comet assay results observed that Q1 and Q2 induce more serious DNA damage than the control (untreated cell); however, in all curried experiments, Q2 showed higher effects than Q1. Hence two synthesized quercetin Schiff bases can take action as a promising anticancer agent.

Keywords: quercetin derivatives, Schiff base, breast cancer, MCF-7 Cytotoxic.
Evaluating the Modified Patient Health Questionnaire-2 and Insomnia Severity Index-2 for Daily Digital Screening of Depression and Insomnia: Validation Study
Authors: Oh Jae Won , Kim Sun Mi , Lee Deokjong , Son Nak-Hoon , Uh Jinsun , Yoon Ju Hong , Choi Yukyung , Lee San
Published: April 2023

Background

The Patient Health Questionnaire-2 (PHQ-2) and Insomnia Severity Index-2 (ISI-2) are screening assessments that reflect the past 2-week experience of depression and insomnia, respectively. Retrospective assessment has been associated with reduced accuracy owing to recall bias.

Objective

This study aimed to increase the reliability of responses by validating the use of the PHQ-2 and ISI-2 for daily screening.

Methods

A total of 167 outpatients from the psychiatric department at the Yongin Severance Hospital participated in this study, of which 63 (37.7%) were male and 104 (62.3%) were female with a mean age of 35.1 (SD 12.1) years. Participants used a mobile app (“Mental Protector”) for 4 weeks and rated their depressive and insomnia symptoms daily on the modified PHQ-2 and ISI-2 scales. The validation assessments were conducted in 2 blocks, each with a fortnight response from the participants. The modified version of the PHQ-2 was evaluated against the conventional scales of the Patient Health Questionnaire-9 and the Korean version of the Center for Epidemiologic Studies Depression Scale–Revised.

Results

According to the sensitivity and specificity analyses, an average score of 3.29 on the modified PHQ-2 was considered valid for screening for depressive symptoms. Similarly, the ISI-2 was evaluated against the conventional scale, Insomnia Severity Index, and a mean score of 3.50 was determined to be a valid threshold for insomnia symptoms when rated daily.

Conclusions

This study is one of the first to propose a daily digital screening measure for depression and insomnia delivered through a mobile app. The modified PHQ-2 and ISI-2 were strong candidates for daily screening of depression and insomnia, respectively.
Understanding Intersectional Ageism and Stigma of Dementia: Protocol for a Scoping Review
Authors: Bacsu Juanita-Dawne , Kortzman August , Fraser Sarah , Chasteen Alison L , MacDonald Jennifer , O'Connell Megan E
Published: April 2023

Background

Ageism and stigma reduce the quality of life of older adults living with dementia. However, there is a paucity of literature addressing the intersection and combined effects of ageism and stigma of dementia. This intersectionality, rooted in the social determinants of health (ie, social support and access to health care), compounds health disparities and is, therefore, an important area of inquiry.

Objective

This scoping review protocol outlines a methodology that will be used to examine ageism and stigma confronting older adults living with dementia. The aim of this scoping review will be to identify the definitional components, indicators, and measures used to track and evaluate the impact of ageism and stigma of dementia. More specifically, this review will focus on examining the commonalities and differences in definitions and measures to develop a better understanding of intersectional ageism and stigma of dementia as well as the current state of the literature.

Methods

Guided by Arksey and O’Malley’s 5-stage framework, our scoping review will be conducted by searching 6 electronic databases (PsycINFO, MEDLINE, Web of Science, CINAHL, Scopus, and Embase) and a web-based search engine (ie, Google Scholar). Reference lists of relevant journal articles will be hand-searched to identify additional articles. The results from our scoping review will be presented using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews) checklist.

Results

This scoping review protocol was registered with the Open Science Framework on January 17, 2023. Data collection and analysis and manuscript writing will occur from March to September 2023. The target date for manuscript submission will be October 2023. Findings from our scoping review will be disseminated through various means, such as journal articles, webinars, national networks, and conference presentations.

Conclusions

Our scoping review will summarize and compare the core definitions and measures used to understand ageism and stigma toward older adults with dementia. This is significant because there is limited research addressing the intersectionality of ageism and stigma of dementia. Accordingly, findings from our study may provide critical knowledge and insight to help inform future research, programs, and policies to address intersectional ageism and stigma of dementia.

Trial Registration

Open Science Framework; https://osf.io/yt49k

International Registered Report Identifier (IRRID)

PRR1-10.2196/46093
Trialling a Large Language Model (ChatGPT) in General Practice With the Applied Knowledge Test: Observational Study Demonstrating Opportunities and Limitations in Primary Care
Authors: Thirunavukarasu Arun James , Hassan Refaat , Mahmood Shathar , Sanghera Rohan , Barzangi Kara , El Mukashfi Mohanned , Shah Sachin
Published: April 2023

Background

Large language models exhibiting human-level performance in specialized tasks are emerging; examples include Generative Pretrained Transformer 3.5, which underlies the processing of ChatGPT. Rigorous trials are required to understand the capabilities of emerging technology, so that innovation can be directed to benefit patients and practitioners.

Objective

Here, we evaluated the strengths and weaknesses of ChatGPT in primary care using the Membership of the Royal College of General Practitioners Applied Knowledge Test (AKT) as a medium.

Methods

AKT questions were sourced from a web-based question bank and 2 AKT practice papers. In total, 674 unique AKT questions were inputted to ChatGPT, with the model’s answers recorded and compared to correct answers provided by the Royal College of General Practitioners. Each question was inputted twice in separate ChatGPT sessions, with answers on repeated trials compared to gauge consistency. Subject difficulty was gauged by referring to examiners’ reports from 2018 to 2022. Novel explanations from ChatGPT—defined as information provided that was not inputted within the question or multiple answer choices—were recorded. Performance was analyzed with respect to subject, difficulty, question source, and novel model outputs to explore ChatGPT’s strengths and weaknesses.

Results

Average overall performance of ChatGPT was 60.17%, which is below the mean passing mark in the last 2 years (70.42%). Accuracy differed between sources (P=.04 and .06). ChatGPT’s performance varied with subject category (P=.02 and .02), but variation did not correlate with difficulty (Spearman ρ=–0.241 and –0.238; P=.19 and .20). The proclivity of ChatGPT to provide novel explanations did not affect accuracy (P>.99 and .23).

Conclusions

Large language models are approaching human expert–level performance, although further development is required to match the performance of qualified primary care physicians in the AKT. Validated high-performance models may serve as assistants or autonomous clinical tools to ameliorate the general practice workforce crisis.
Using the Kirkpatrick model to evaluate the effect of a Primary Trauma Care course on healthcare workers knowledge, attitude, and practice (KAP) in two Vietnamese local hospitals. (Preprint)
Authors: Nguyen Ba Tuan , Nguyen Van Anh , Blizzard Christopher Leigh , Palmer Andrew , Nguyen Huu Tu , Quyet Thang Cong , Tran Viet , Skinner Marcus , Perndt Haydn , Nelson Mark
Published: April 2023

BACKGROUND

The Primary Trauma Care (PTC) course was originally developed to instruct healthcare workers in the management of the severely injured patients in low and middle income countries with limited medical resources. The PTC has now been taught for more than 25 years. Many studies have demonstrated that the two-day Primary Trauma Care (PTC) workshop is a useful and informative to front-line health staff and has helped improve knowledge and confidence in trauma management but there is little evidence showing that it leads to changes in clinical practice. The Kirkpatrick (KM) and Knowledge Attitude Practice (KAP) models are effective methods to evaluate this approach. Our study aimed to combine 2 models to evaluate the impact of the PTC program for healthcare staff in two Vietnamese hospitals.

OBJECTIVE

to investigate how the “2 day PTC course” impacts on the level of clinical practice in healthcare staff in the emergency departments of two Vietnamese provincial hospitals.

METHODS

We conducted the PTC course over 2 days in the emergency departments (ED) of Thanh Hoa and Ninh Binh hospitals in February and March 2022 respectively. Sequential cross-sectional surveys using validated instruments were conducted immediately pre- and post-course and at 6 months after course delivery. The questionnaires were analysed by simple frequency analysis.

RESULTS

At level 1 of KM, nearly 100 % participant were satisfied with the course. At level 2 (knowledge), the multiple-choice question (MCQ) and confident matrix (CM) improved significantly from 60% to 77% and 59.3% to 71.3% respectively (p<0.01), these improvements were seen in both nurse and doctor subgroups. The focus of Level 3 was on practice and saw a significant incremental change with scenarios checklist (SC) points jumping from 5.9 1.9 to 9.0 0.9 and bedside clinical checklist (BCC) points increased from 5 1.5 to 8.3 0.8 (p<0.01). At 6-months follow up, MCQ, CM and SC all remained unchanged (p>0.05) except MCQ score in the nurse subgroup (p<0.01).

CONCLUSIONS

The PTC course undertaken in 2 local hospitals of Vietnam was successful in improving 3 levels of KM for ED healthcare staff. This improvement was maintained for at least 6 months post course. The PTC courses are effective in providing improvement and sustainment in 3 Levels for low- and middle-income countries like Vietnam.

CLINICALTRIAL

The trial is registered in ANZCTR with trial ID is ACTRN12621000371897.
How well ChatGPT performs in Forensic Medicine (Including Medical Jurisprudence & Toxicology) of Third Professional MBBS: Part 1? (Preprint)
Authors: Ashok Joshua , V Hariprasad , Mohan Ashok Kumar , Surapaneni Krishna Mohan
Published: April 2023

UNSTRUCTURED

ChatGPT, the state-of-the-art innovation in the field of Artificial Intelligence (AI) is gaining massive popularity with its notable ability to generate human-like responses within shortest span of time. The utility of ChatGPT is being assessed possibly in all fields now with education predicted to be one of the key areas to be highly benefitted by ChatGPT. In view of this, we evaluated the performance of ChatGPT in Forensic Medicine. All our questions regarding the subject were satisfactorily addressed by ChatGPT.
Five Strategies Leaders in Academic Medicine Can Implement Now to Enhance Gender Equity (Preprint)
Authors: Allan Jessica M , Brooks Amber K , Crusto Cindy , Feld Lauren D , Oxentenko Amy S , Spector Nancy D , Verduzco-Gutierrez Monica , Silver Julie K
Published: April 2023

UNSTRUCTURED

Abundant disparities for women in medicine contribute to many women physicians considering leaving medicine. There is a strong financial and ethical case for leaders in academic medicine to focus on strategies to improve retention. This article focuses on five immediate actions that leaders can take to enhance gender equity and improve career satisfaction for all members of the workplace.
Maternal Social Loneliness Detection Using Passive Sensing Through Continuous Monitoring in Everyday Settings: Longitudinal Study (Preprint)
Authors: Sarhaddi Fatemeh , Azimi Iman , Niela-Vilen Hannakaisa , Axelin Anna , Liljeberg Pasi , Rahmani Amir M
Published: April 2023

BACKGROUND

Maternal loneliness is associated with adverse physical and mental health outcomes for both the mother and her child. Detecting maternal loneliness noninvasively through wearable devices and passive sensing provides opportunities to prevent or reduce the impact of loneliness on the health and well-being of the mother and her child.

OBJECTIVE

The aim of this study is to use objective health data collected passively by a wearable device to predict maternal (social) loneliness during pregnancy and the postpartum period and identify the important objective physiological parameters in loneliness detection.

METHODS

We conducted a longitudinal study using smartwatches to continuously collect physiological data from 31 women during pregnancy and the postpartum period. The participants completed the University of California, Los Angeles (UCLA) loneliness questionnaire in gestational week 36 and again at 12 weeks post partum. Responses to this questionnaire and background information of the participants were collected through our customized cross-platform mobile app. We leveraged participants’ smartwatch data from the 7 days before and the day of their completion of the UCLA questionnaire for loneliness prediction. We categorized the loneliness scores from the UCLA questionnaire as loneliness (scores≥12) and nonloneliness (scores<12). We developed decision tree and gradient-boosting models to predict loneliness. We evaluated the models by using leave-one-participant-out cross-validation. Moreover, we discussed the importance of extracted health parameters in our models for loneliness prediction.

RESULTS

The gradient boosting and decision tree models predicted maternal social loneliness with weighted F1-scores of 0.897 and 0.872, respectively. Our results also show that loneliness is highly associated with activity intensity and activity distribution during the day. In addition, resting heart rate (HR) and resting HR variability (HRV) were correlated with loneliness.

CONCLUSIONS

Our results show the potential benefit and feasibility of using passive sensing with a smartwatch to predict maternal loneliness. Our developed machine learning models achieved a high F1-score for loneliness prediction. We also show that intensity of activity, activity pattern, and resting HR and HRV are good predictors of loneliness. These results indicate the intervention opportunities made available by wearable devices and predictive models to improve maternal well-being through early detection of loneliness.

CLINICALTRIAL
Implementation of Machine Learning Applications in Health Care Organizations: Protocol for a Systematic Review of Empirical Studies (Preprint)
Authors: Ardito Vittoria , Cappellaro Giulia , Compagni Amelia , Petracca Francesco , Preti Luigi Maria
Published: April 2023

BACKGROUND

An increasing interest in machine learning (ML) has been observed among scholars and health care professionals. However, while ML-based applications have been shown to be effective and have the potential to change the delivery of patient care, their implementation in health care organizations is complex. There are several challenges that currently hamper the uptake of ML in daily practice, and there is currently limited knowledge on how these challenges have been addressed in empirical studies on implemented ML-based applications.

OBJECTIVE

The aim of this systematic literature review is twofold: (1) to map the ML-based applications implemented in health care organizations, with a focus on investigating the organizational dimensions that are relevant in the implementation process; and (2) to analyze the processes and strategies adopted to foster a successful uptake of ML.

METHODS

We developed this protocol following the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) guidelines. The search was conducted on 3 databases (PubMed, Scopus, and Web of Science), considering a 10-year time frame (2013-2023). The search strategy was built around 4 blocks of keywords (artificial intelligence, implementation, health care, and study type). Based on the detailed inclusion criteria defined, only empirical studies documenting the implementation of ML-based applications used by health care professionals in clinical settings will be considered. The study protocol was registered in PROSPERO (International Prospective Register of Systematic Reviews).

RESULTS

The review is ongoing and is expected to be completed by September 2023. Data analysis is currently underway, and the first results are expected to be submitted for publication in November 2023. The study was funded by the European Union within the Multilayered Urban Sustainability Action (MUSA) project.

CONCLUSIONS

ML-based applications involving clinical decision support and automation of clinical tasks present unique traits that add several layers of complexity compared with earlier health technologies. Our review aims at contributing to the existing literature by investigating the implementation of ML from an organizational perspective and by systematizing a conspicuous amount of information on factors influencing implementation.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/47971
Devouring Time: A Study of the Narrative Time in Jennifer Egan’s A Visit from the Goon Squad
Authors: Wang Ling
Published: April 2023

Jennifer Egan’s Pulitzer-prize-winning novel A Visit from the Goon Squad conceives of time as a brutalizing force which ravages characters who wonder where time went. The novel calls attention to readers’ own experience of time passing. Order, duration, frequency; time passed and time regained; time’s forward march and memory’s backward loops: these are the recurring preoccupations of this novel. However, most academic researches focus on the author’s interviews, thematic analysis, and the novel’s postmodernist characteristics etc. Based on Gérard Genette’s theory of the narrative time, this article studies how Egan demonstrates the theme of the “passage of time” in her writing through a deliberate arrangement of the narrative time.
EVALUATION OF SERUM AND SALIVARY CA-125 IN BREAST CANCER PATIENTS – AN ANALYTICAL STUDY
Authors: DWIVEDI URVASHEE , JAIN ANURAG , ALI FATIMA BHOPALWALA , Ali Mustafa
Published: April 2023

Objective: Breast cancer in females is very frequent nowadays both in developed and developing countries. Many tests both invasive and non-invasive are available for the diagnosis of cancer breast. Tumor markers are the substances that are associated with tumors and help in the detection and follow-up. Cancer antigen 125 (CA-125) is one of the tumor markers, the level of which increases in many tumors including breast cancer.
Methods: The present study was carried out to quantitatively measure its level by enzyme-linked immunosorbent assay in the serum and saliva of known breast cancer patients and comparing it with control groups.
Results: Statistically significant role of CA-125 in cases of breast cancer was ascertained over the control group and also positive correlation was found between serum and salivary values of CA-125.
Conclusion: We conclude that CA-125 can be used as tumor markers in breast cancer patients for evaluation and salivary samples are equally effective as serum samples and also are easy and safe to obtain.
A CROSS-SECTIONAL STUDY TO EVALUATE ACUTE KIDNEY INJURY IN SCRUB TYPHUS PATIENTS
Authors: Pani Shradhanjali , Sethi Taranisen , Kumarpatel Nayan , Majhi Chakradhar
Published: April 2023

Objective: This study was conducted with the objective to estimate the incidence and severity of acute kidney injury (AKI) scrub typhus patients. Methods: This was a cross-sectional study conducted 90 patients diagnosed with scrub typhus in a tertiary care center. Basic demographic and treatment details of the patients were recorded. Routine hematological investigations and biochemical profiles were performed upon admission and follow-up. AKI was defined and classified based on the RIFLE criteria. Results: Mean age of the patients was 49.0±19.5 years and female preponderance was observed. The hemoglobin level was significantly lower in AKI patients as compared to non-AKI patients. Meanwhile, there was a significant increase in mean TLC count, CRP, total bilirubin in AKI patients as compared to non-AKI patients. was significantly higher as compared to those without AKI. Increasing age, ICU admission, shock, urinary abnormalities, and mechanical ventilation were the factors significantly associated with AKI. Conclusion: AKI is a frequently reported complication in scrub typhus patients. In evaluating febrile illness associated with AKI, scrub typhus should be considered.
ASSESSMENT OF LIFESTYLE CHANGES AND THEIR EFFECT ON HEALTH AMONG CHILDREN OF ≤15 YEARS DURING COVID-19 PANDEMIC, IN NORTH INDIA
Authors: Rajpoot Atul , Patidar Anand K , Jain Anurag , Sharma Vikash , Gupta Preeti , Gupta Mahesh
Published: April 2023

Objective: The objectives of the study were: (1) To assess life style changes among children of ≤15 years of age during COVID-19 pandemic and (2) to find out the effect of the life style changes on health of children of ≤15 years of age.
Methods: The cross-sectional comparative study conducted at department of pediatrics, Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow for duration of 1 year and sample size found to be 276 on calculation by applying the formula.
Results: Out of 278 children, about 39% (108) were female children. Most of children were studying in primary level classes (52.51%) and most of enrolled children had joint family (66.18%). Level of physical activity reduced significantly due to closure of school and restriction on outdoor activities. Weight of children increased significantly during COVID-19 pandemic seems to be due to decreased in physical activities and consumption of more fast food/fried food (high calorie intake) and sedentary life style.
Conclusion: During COVID-19 pandemic due to closure of schools and restricted outdoor activities results in decrease level of physical activities, increased consumption of high calorie food and sedentary behavior lead to increase in weight of children and changes in sleeping pattern of children.
In silico analysis of ACE2 from different animal species provides new insights into SARS-CoV-2 species spillover
Authors: Mesquita Felipe Pantoja , Noronha Souza Pedro Filho , Aragão Dyane Rocha , Diógenes Expedito Maia , da Silva Emerson Lucena , Amaral Jackson Lima , Freire Valder Nogueira , Souza Collares Maia Castelo-Branco Débora de , Montenegro Raquel Carvalho
Published: April 2023

Aim: This study aimed to analyze the phylogenetic relationships between the ACE2 of humans and other animals and investigate the potential interaction between SARS-CoV-2 RBD and ACE2 of different species. Materials & methods: The phylogenetic construction and molecular interactions were assessed using computational models. Results & conclusion: Despite the evolutionary distance, 11 species had a perfect fit for the interaction between their ACE2 and SARS-CoV-2 RBD ( Chinchilla lanigera, Neovison vison, Rhinolophus sinicus, Emballonura alecto, Saccopteryx bilineata, Numida meleagris). Among them, the avian N. meleagris was reported for the first time in this study as a probable SARS-CoV-2 host due to the strong molecular interactions. Therefore, predicting potential hosts for SARS-CoV-2 for understanding the epidemiological cycle and proposal of surveillance strategies.
INFLUENCE ANALYSIS OF MURABAHAH AND MUSYARAKAH RECEIVABLES WITH MODERATED REGRESSION ANALYSIS METHOD
Authors: Elfiswandi Elfiswandi , Fikri Ramadhan Muhammad , Mayang Sari Fitri Indah , Rosalina Desi
Published: April 2023

This study aims to determine how influential Murabahah and Musyarakah receivables are on the profitability of Islamic banks with non-performing financing as a moderating variable. The population in this study are Islamic banks in Indonesia from 2015 to 2019. The sample for this study is 14 banks. This research methodology uses a saturated sample, namely where the entire population is sampled. data analysis method using panel data regression, EVIEWS. Based on the results of this study.  Murabaha receivables have a negative effect on the profitability of Islamic banks. Musyarakah financing affects the Profitability of Islamic Banks. Murabahah Receivables and Musyarakah Financing jointly affect the Profitability of Islamic Banks. Non-performing financing weakens the relationship between Murabahah Receivables and Sharia Bank Profitability. Non performing financing strengthens the relationship between Musyarakah Financing and Sharia Bank Profitability
THE DEVELOPMENT OF GAMMA RADIATION DOSIMETERS REAL-TIME NETWORK-BASED SENSOR WIRELESS IEEE 802.15.4 PROTOCOL
Authors: Fardela Ramacos
Published: April 2023

Several studies have been carried out on the development of real-time gamma radiation dosimeter based on the wireless sensor network (WSN) protocol IEEE 802.15.4. WSN technology can be adopted to develop a gamma radiation dose monitoring system on a large scale due to its real-time, centralized, efficient, and relatively low-cost attributes. This study aims to develop a personal radiation dosimeter that can collect data from the measurement results of several sensor nodes or multi-sensors. The measurement results of radiation dose values from many radiation workers are sent to a coordinator node consisting of the Xbee module and Arduino as a microcontroller. The system test is compared with a calibrated dosimeter reading and is expected to be one of the instruments for determining radiation dose in real-time. It can also reduce the risk of receiving a radiation dose that exceeds the threshold allowed by the ionizing control agency and a program in radiation protection. Changes in the intensity of radiation emitted by Cs-137 (gamma radiation) are carried out by varying each detector's distance to the source, which indirectly varies the value of the dose rate received by the detector. This relationship is shown from the value of R2 = 0.99, which indicates a strong correlation between changes in the dose given to the detector's response being developed. The system built is efficient, inexpensive, and collecting radiation exposure data can monitor radiation exposure received by workers in real-time. This technique can help speed up reporting of radiation exposure received by radiation workers.
Development of e-modules based on science literacy and Islamic values in ecosystem materials
Authors: Fikri Achmad Ali , Rahmaniyyah Alfiyatul
Published: April 2023

In the reality of general education, many teachers still use conventional teaching materials, namely teaching materials that are ready, can be purchased instantly, without having to plan, prepare and organize themselves. The purpose of this study was to determine the feasibility of developing e-modules based on scientific literacy and Islamic value in biology learning on ecosystem material for class X IPA at MA Mu'allimat NU Kudus. This Study use he 4-D research model which was modified into a 3-D development model by eliminating the disseminate stage so that the research was only carried out until the develop stage. The subjects of the product trial totaling 42 students. Data collection techniques with validation instruments by material expert lecturers, media expert lecturers, practitioners, and the student response questionnaire. The results of the material expert validation were obtained "very feasible", the results of the media expert validation were obtained "very feasible", and the results of the biology teacher's validation were also obtained "very feasible". Student response to the e-module was obtained "very feasible". So that this research succeeded in developing e-modules and is very suitable for use as teaching materials. The results of this study are expected to answer the need for media in learning activities, besides that it is also able to motivate teachers to develop more in class.
Application of Burden of Proof to Child Labour as Protection of Children's Rights
Authors: Fauzi Ahmad , Arif F M. Noor Fajar Al
Published: April 2023

Child labour should be given legal protection, one form of protection for child labour is to impose a Burden of Proof (Burden of Proof) for child labour in accordance with the provisions of the ILO Convention (International Labor Organization) No. 138 of 1973 on the minimum age to be allowed to work and the ILO (International Labour Organization) Convention No. 183 then 1999 on the abolition of the worst forms of work for. This research aims to examine the philosophical foundation of the burden of proof in the Indonesian legal system and to examine the burden of proof implementation for child labour in Indonesia. This research is legal research using a normative juridical approach, the data used are primary data and secondary data analyzed using quantitative analysis. The results of the study are the first philosophical application of the principle of reverse burden of proof that has been regulated in various legal rules in Indonesia, including Law No. 8 of 1999 on Consumer Protection, Law No. 40 of 2007 concerning limited Company legal No. 32 of 2009 on the protection and management of the environment and the provisions of the crime of corruption relating to the freezing, expropriation and confiscation of the perpetrators of the crime of corruption in accordance. Both countries have ratified ILO Convention No. 138 of 1973 on the Minimum age to be allowed to work and ILO Convention No. 182 of 1999 on the Prohibition and immediate action on the elimination of the worst forms of Child Labour which affirms the existence of a reverse proof for child labour.
Legal Consequences of Bankruptcy on Joint Assets after Divorce
Authors: Dewi Putu Eka Trisna
Published: April 2023

Marriage is a legal event that makes a physical and spiritual bond between a man and a woman as husband and wife with the aim of forming a happy and eternal family (household) based on the one and only God. However, not all marriages go as expected which leads to divorce. Marriage creates a union of assets called joint property. In the process of marriage, there are often a number of debts that the husband and wife cannot afford to pay because their joint assets are insufficient to pay these debts. The inability of a husband and wife to pay debts to creditors can be declared bankrupt based on a court decision. This will lead to a problem for joint assets when bankruptcy occurs after a divorce. This study aims to examine the legal consequences of bankruptcy on joint assets after divorce. The type of research is normative legal research. This legal research method is related to the principles and norms of bankruptcy law in Indonesia, in that, legal research is a process to find legal rules to answer the legal issues being faced. The types of approaches used are the statute approach, conceptual approach and legal facts approach. The results of this study showed that in Article 23 of the Bankruptcy Law, it is explained that if a person is declared bankrupt, those who participate in bankruptcy include the wife or husband with the status that the wife/husband after marriage is related to the union of assets. The legal consequences of the bankruptcy of joint assets that have not been divided after the divorce refer to the provisions for the distribution of joint assets in the marriage law and the Civil Code.