bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidence, clinical features, risk factors, and outcomes of Intraocular inflammation following Brolucizumab in Indian eyes – A multicentric study
Authors: Chakraborty Debdulal , Mondal Soumen , Sengupta Sabyasachi , Abbas Zahir , Chandra Khushboo , Boral Subhendu , Maiti Aniruddha , Roy Sangeeta , Mukherjee Angshuman , Das Arnab , Chakraborty Somnath , Nag Pinaki
Published: May 2023

Purpose:

To report the incidence, clinical features, potential risk factors, and outcomes of intraocular inflammation (IOI) following brolucizumab in Indian eyes.

Methods:

All consecutive patients diagnosed with brolucizumab-induced IOI from 10 centers in eastern India between October 2020 and April 2022 were included.

Results:

Of 758 injections given during the study period across centers, 13 IOI events (1.7%) were recorded attributable to brolucizumab. The IOI occurred after the first dose in two eyes (15%) (median 45 days after brolucizumab), second dose in six eyes (46%) (median = 8.5 days), and third dose (39%) in the remaining five eyes (median 7 days). Reinjections of brolucizumab were administered at a median interval of 6 weeks (interquartile range = 4–10 weeks) in the 11 eyes, where IOI occurred after the second or third dose. Eyes that experienced IOI after the third dose had received a significantly greater number of previous antivascular endothelial growth factor injections (median = 8) compared to those who developed it after the first or second dose (median = 4) (P = 0.001). Anterior chamber cells were seen in almost all eyes (n = 11, 85%), while peripheral retinal hemorrhages were seen in two eyes, and one eye showed branch artery occlusion. Two-thirds of patients (n = 8, 62%) recovered with a combination of topical and oral steroids, while remaining recovered with topical steroids alone. Irreversible visual loss was not seen in any eye, and median vision recovered to pre-IOI levels by 3 months’ time point.

Conclusion:

Brolucizumab-induced IOI was relatively rare, occurring in 1.7% of eyes, was more common after the second or third injection, especially in those who required frequent reinjections every 6 weeks, and occurred earlier with increasing number of previous brolucizumab injections. Continued surveillance is necessary even after repeated doses of brolucizumab.
Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccination
Authors: Mahendradas Padmamalini , Parmar Yash , Mishra Sai Bhakti , Patil Aditya , Kawali Ankush , Sanjay Srinivasan , Shetty Bhujang
Published: May 2023

The aim of this study is to report the clinical features, imaging findings including confocal imaging, corneal nerve fiber analysis, and management outcomes in a series of three cases of varicella zoster virus (VZV) reactivation following one dose of coronavirus disease 2019 (COVID-19) vaccination. This was a retrospective and observational study. All the patients who developed uveitis post-vaccination were pooled together. Patients who had VZV reactivation were included. Two cases had polymerase chain reaction positive for VZV from aqueous humor. At the time of presentation, IgG and IgM spike protein antibodies for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were tested. Out of this pool, three patients with classical features to describe pole-to-pole manifestations were chosen. A 36-year-old lady with post-vaccination sclerokeratouveitis associated with reactivation of herpes zoster ophthalmicus, a 56-year-old lady with post-vaccination acute anterior uveitis associated with herpes zoster ophthalmicus, and a 43-year-old gentleman with post-vaccination acute retinal necrosis were included. We present a possible link between anti-SARS-CoV-2 virus vaccination and varicella zoster reactivation in these patients and also describe the clinical features, imaging findings including confocal imaging, corneal nerve fiber analysis, and management with detailed discussion.
Bibliometric analysis of pediatric glaucoma
Authors: Jain Divya , Dhua Anjan Kumar
Published: May 2023

Purpose:

The research activity in pediatric glaucoma (PG) was qualitatively and quantitatively evaluated using a scientometric approach.

Methods:

The “Web of Science” database was accessed for primary bibliometric data regarding PG using search terms “pediatric glaucoma,” “paediatric glaucoma,” “congenital glaucoma,” and “childhood glaucoma.” The data was analyzed for total research productivity, citations, and scientific output in terms of journals, countries, institutions, and authors. The results were further characterized for coauthorship links and visualized by VOS viewer software. Also, the top 25 cited articles were reviewed with the above bibliometric characteristics.

Results:

One thousand two hundred and sixty-nine items were obtained from our search query from 1955 to 2022; these received 15,485 citations, originated from 78 countries. The top-3 contributing countries were the United States of America (n = 369), India (n = 134), and China (n = 127). LV Prasad Eye Institute (n = 58), Duke University (n = 44), and King Khalid Eye Specialist Hospital (n = 42) were the top-3 productive institutes. The top-3 prolific authors were Mandal AK (n = 53), Freedman, SF (n = 36), and Sarfarazi, M (n = 33). Journal wise, “Investigative Ophthalmology” (n = 187), “Journal of Glaucoma” (n = 92), and “Journal of AAPOS” (n = 68) were the journals in which the most articles were published. The top-25 cited documents received 3564 citations and were published between 1977 and 2016. The key areas of interest were basic sciences (genetics of childhood glaucoma) and surgical management.

Conclusion:

United States of America, LVPEI, Mandal AK, and “Investigative Ophthalmology” were the top rankers as far as the productivity and publications related to PG are concerned. Articles on molecular genetics in PG have received interest among the ophthalmology community.
Visual outcomes of early enhancement following small incision lenticule extraction versus laser in situ keratomileusis
Authors: Soundarya B , Sachdev Gitansha Shreyas , Ramamurthy Shreyas , Kumar Shreesha K , Dandapani Ramamurthy
Published: May 2023

Purpose:

To compare visual outcomes of early enhancement following small incision lenticule extraction (SMILE) versus laser in situ keratomileusis (LASIK).

Methods:

Retrospective analysis of eyes (patients operated in the setting of a tertiary eye care hospital between 2014 and 2020) requiring early enhancement (within one year of primary surgery) was conducted. Stability of refractive error, corneal tomography, and anterior segment Optical Coherence Tomography (AS-OCT) for epithelial thickness was performed. The correction post regression was done using photorefractive keratectomy and flap lift in eyes, wherein the primary procedure was SMILE and LASIK, respectively. Pre- and post enhancement corrected and uncorrected distance visual acuity (CDVA and UDVA), mean refractive spherical equivalent (MRSE), and cylinder were analyzed. IBM SPSS statistical software.

Results:

In total, 6350 and 8176 eyes post SMILE and LASIK, respectively, were analyzed. Of these, 32 eyes of 26 patients (0.5%) post SMILE and 36 eyes of 32 patients (0.44%) post-LASIK required enhancement. Post enhancement (flap lift in LASIK, and PRK in SMILE group) UDVA was logMAR 0.02 ± 0.05 and 0.09 ± 0.16 (P = 0.009), respectively. There was no significant difference between the refractive sphere (P = 0.33) and MRSE (P = 0.09). In total, 62.5% of the eyes in the SMILE group and 80.5% in the LASIK group had a UDVA of 20/20 or better (P = 0.04).

Conclusion:

PRK post SMILE demonstrated comparable results to flap lift post LASIK and is a safe and effective approach for early enhancement post SMILE.
A novel two-surgeon technique of simultaneous bilateral cataract surgery with complete delinking
Authors: Madhivanan Nishanth , Madhivanan Nivean , Nishanth Shruti , Nivean Pratheeba Devi , Sekaran Sangeetha , Malarkodi S , Ramesh Prasanna Venkatesh
Published: May 2023

Though technological advancements have transcended beyond expectation, phacoemulsification remains a challenge in uncooperative patients, where the procedure may be contemplated under general anesthesia, with simultaneous bilateral cataract surgery (SBCS) being the surgery of choice. In this manuscript, we have reported a novel two-surgeon technique of SBCS on a 50-year-old mentally subnormal patient. Under general anesthesia, two surgeons performed phacoemulsification simultaneously, using two separate microscopes, irrigation lines, phaco machines, instruments, and assistants. Intraocular lens (IOL) implantation was performed in both eyes (OU). The patient had a visual recovery from 5/60, N36 in OU preoperatively to 6/12, N10 in OU on post-operative day 3 and 1 month, with no complications. This technique can potentially reduce the risk of endophthalmitis, repeated and prolonged anesthesia, and the number of hospital visits. To the best of our knowledge, this two-surgeon technique of SBCS has never been reported in the literature.
Imaging iridotrabecular contact in angle closure
Authors: Mansoori Tarannum
Published: May 2023

Background:

With ultrasound biomicroscopy (UBM), radial scans are taken by using a typical ciliary process, to show the details of the iridocorneal angle, the anterior surface of the ciliary body, and its relation to the posterior iris. Appositional closure represents potentially reversible contact between the peripheral iris and trabecular meshwork. The appositional closure can further be classified according to the configuration of iridotrabecular contact (ITC). UBM can be performed in dark and light conditions, which has been shown to be useful for detecting changes in iridocorneal angle configuration associated with dark and light.

Purpose:

To image ITC configuration in appositional angle closure and also image iridocorneal angle in dark and bright light room illumination.

Synopsis:

UBM demonstrates two types of ITC configuration in appositional closure which are, B-type and S-type. It can also demonstrate the presence of sinus of Mapstone in S-type of ITC.

Highlights:

UBM allows imaging of dynamic changes in the iris and shows that the degree of appositional angle closure is a dynamic process that can change rapidly depending on the lighting conditions.

Video link:
https://youtu.be/tgN4SLyx6wQ.

Key words: Appositional angle closure, B and S type appositional closure, dark- light condition, ultrasound biomicroscopy
Enraizamento in vitro e aclimatização de plântulas de Corymbia citriodora
Authors: Maravilha Luiz Filipe , Titon Miranda , Canguçu Vitória de Souza , Rocha Fabiana Miranda , Oliveira Marcio Leles Romarco de
Published: May 2023

O objetivo do presente trabalho foi avaliar o efeito de concentrações de ácido indolbutírico (AIB) no enraizamento in vitro de brotações juvenis de Corymbia citriodora, e formas de vedação na aclimatização de plântulas micropropagadas. Para o enraizamento, foram colocadas brotações em meio de cultura com quatro concentrações de AIB (0; 1,0; 2,0 e 4,0 mg L-1). Na pré-aclimatização, plântulas germinadas in vitro e isentas de contaminação foram transplantadas para copos de polietileno contendo substrato. Os copos foram embalados em sacos plásticos por 10 dias e mantidos em sala de cultura. Posteriormente, foram aplicados três tratamentos: ausência de cobertura; saco plástico intacto e saco plástico perfurado. Na aclimatização, manteve-se o histórico dos tratamentos da pré-aclimatização. As plântulas foram transplantadas para tubetes contendo substrato e mantidas inicialmente em casa de vegetação e depois em casa de sombra. Os resultados demonstram que as concentrações de 1,0; 2,0 e 4,0 mg L-1 de AIB foram eficientes no enraizamento de explantes juvenis de C. citriodora, sendo que a maior concentração utilizada proporcionou o maior número médio de raízes. Recomenda-se a ausência de cobertura na pré-aclimatização para maior taxa de sobrevivência, altura e massa seca das mudas na etapa de aclimatização.
Further Discussion on Implementing Environmental and Law on Environmental Protection 2020
Authors: Trong Diep Nguyen , Anh Thu Nguyen , Hung Nhan Pham
Published: May 2023

Environmental protection is activities that keep the environment clean and beautiful. Improve the environment, ensure ecological balance. Preventing and overcoming bad consequences caused by humans and nature to the environment. Exploit, rationally and economically use natural resources. Environmental protection activities must be conducted regularly, openly and transparently; Prioritize forecasting, prevention of pollution, incidents, environmental degradation, management of environmental risks, reduction of generation and waste, increased reuse and recycling of waste to exploit the value of resources. source of waste. The Law on Environmental Protection in 2020 has promoted the role of people, businesses and the whole political system in participating in environmental protection activities.
Case Study Teaching Method and Examples of Implementing Environmental and Law
Authors: Anh Thu Nguyen , Trong Diep Nguyen , Ngoc Huy Dinh Tran , Hung Nhan Pham
Published: May 2023

Environmental protection activities mean activities to prevent and limit adverse impacts on the environment; responding to environmental incidents; overcome pollution, environmental degradation, improve environmental quality; rational use of natural resources, biodiversity and response to climate change. The Law on Environmental Protection has promoted the role of people, businesses and the whole political system in participating in environmental protection activities. This paper also present a case of Vedan and Thi vai river pollutions, via which authorities resolutely organize the implementation of measures to handle violations of the law on environmental protection for Vedan Company.
More Discussion on Land Law and Regulations for Industrial Zones Land
Authors: Trong Diep Nguyen , Anh Thu Nguyen
Published: May 2023

The study purpose is to present More Discussion on Land Law and Regulations for Using Industrial Zones Land. Land in industrial zones or land in industrial zones belonging to non-agricultural production and business land. This is land to build industrial clusters, industrial parks, export processing zones and other concentrated production and business zones with the same land use regime. The process of organizing the implementation of the 2013 Land Law has revealed shortcomings and limitations which is not suitable with the socialist-oriented market economy institution and the development requirements of the country.
Canti e preghiere dal siddur giudeo-provenzale (Ms. Leeds, Brotherton Library, Roth 32): considerazioni linguistiche e stilistiche
Authors: Baricci Erica
Published: May 2023

Il ms. Roth 32 della Brotherton Library di Leeds, redatto in Provenza alla fine del 1400, è l’unico testimone noto di un siddur (libro ebraico di preghiere) in giudeo-provenzale. Esso costituisce un’importante fonte di informazioni sia sul rito degli ebrei di Provenza nel XV secolo, sia sulla lingua giudeo-provenzale. In questo articolo presento l’edizione di alcuni canti e preghiere conservati nel ms. Roth 32, finora inediti e, sulla base del materiale linguistico offerto, formulo alcune considerazioni di carattere linguistico e stilistico su questa specifica varietà di provenzale. In particolare, analizzo il metodo di traduzione dall’ebraico al giudeo-provenzale, chiarendo il significato di termini rari o non attestati nel provenzale “cristiano” coevo: talvolta si tratterà di neologismi, talvolta di prestiti (persino dal giudeo-arabo), talvolta di termini attestati finora solo nel provenzale moderno; inoltre, considero il rapporto tra il giudeo-provenzale “scolastico” riflesso nel siddur e qualche spia della lingua parlata dagli ebrei dell’epoca, per mettere in evidenza la complessità diafasica di questo idioma. Infine, opero un confronto tra le traduzioni giudeo-provenzale e giudeo-italiana dello shema‘ Israel per trarre qualche considerazione sull’annosa questione che riguarda la comune tradizione delle traduzioni giudeo-romanze e la loro eventuale origine giudeo-latina.
ANALISIS KEGUNAAN UANG KAS DALAM KELANCARAN AKTIVITAS PERUSAHAAN PADA PT. PUTERA RAJA MEDAN
Authors: Amazihono Anita Niscaya , Apriani Siska
Published: May 2023

Adapun tujuan dari penelitian adalah menganalisis kegunaan Uang Kas dalam Kelancaran Aktivitas Perusahaan PT Putera Raja Sejahtera Medan. Penelitian ini dilaksanakan pada lingkup PT Putera Raja Sejahtera Medan dengan objek penelitian dibatasi hanya pada uang kas dan kelancaran aktivitas operasional perusahaan yang ditinjau dari penjualan. Sampel penelitian adalah data laporan keuangan triwulan PT Putera Raja Sejahtera Medan selama 3 (tiga) tahun yaitu dari tahun 2017 sampai dengan tahun 2019. Hasil penelitian diperoleh Pada tahun 2017 jumlah kas masuk (sumber kas) adalah sebesar 59.014.000.00 Sedangkan pengeluaran kas adalah sebesar 55.766.000.00 Karena sumber kas lebih besar dari penggunaan kas, maka menyebabkan nilai kas bertambah sebesar 3.248.000.00 Pada Tahun 2018 kas masuk (sumber kas) adalah sebesar 66.769.000.00, sedangkan jumlah pengeluaran kas selama tahun 2018 adalah sebesar 69.794.000.00 Karena sumber kas lebih kecil dari penggunaan kas, maka menyebabkan nilai kas berkurang sebesar 3.025.000.00. Pada tahun 2019 kas masuk (sumber kas) adalah sebesar 37.137.000.00, sedangkan jumlah pengeluaran kas selama tahun 2019 adalah sebesar 37.913.000.00. Karena sumber kas lebih kecil dari penggunaan kas, maka menyebabkan nilai kas berkurang sebesar 776.000.00.
PERANAN KUALITAS PELAYANAN DALAM MENINGKATKAN KEPUASAN PELANGGAN PADA DINAS PENCEGAH DAN PEMADAM KEBAKARAN KOTA MEDAN
Authors: Sitio Fandi Winata , Hutapea Tito Santana
Published: May 2023

Penelitian ini bertujuan untuk mengetahui Peranan Kualitas Pelayanan dalam Meningkatkan Kepuasan Pelanggan pada Dinas Pencegah dan Pemadam kebakaran Kota Medan. Metode analisis data yang digunakan yaitu dengan  metode deskriptif dan deduktif, Berdasarkan hasil pembahasan yang dilakukan maka dapat disimpulkan bahwa pelayanan yang telah diberikan oleh petugas pemadam kebakaran telah berjalan dengan baik dimana dalam melaksanakan pelayanan publik berdasarkan dimensi pelayanan yaitu sikap petugas, prosedur, waktu fasilitas dan pelayanan. Faktor-faktor yang mempengaruhi indeks kepuasan masyarakat pada seksi Pencegah dan Pemadam Kebakaran Kota Medan yaitu Sumber Daya Manusia yaitu kemampuan petugas pemadam kebakaran dalam melaksakan tugas sangat baik, ini dikarenakan para petugas telah mengikuti pelatihan tentang pencegahan dan pemadam kebakaran dan Sarana Prasarana.  Dan penulis menyarankan supaya instansi terus mengembangkan kualitas pelayanan publik terhadap masyarakat kota Medan dan untuk peneliti selanjutnya sebaiknya ditambahkan faktor-faktor lainnya yang dapat mengembangkan peranan kualitas pelayanan bagi masyarakat.
PENGARUH PERPUTARAN MODAL KERJA TERHADAP CURRENT RASIO PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Zai Nirmawati , Sinaga Erni
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh perputaran modal kerja terhadap current ratio pada perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia periode 2017-2019. Rumusan masalah penelitian yaitu apakah perputaran modal kerja berpengaruh terhadap current ratio dimana populasi penelitian adalah sebanyak 37 perusahaan teknik pengambilan sampel dilakukan berdasarkan teknik purposive sampling sesuai dengan kriteria yang ditentukan, sampel dalam penelitian adalah sebanyak 16 Perusahaan. Berdasarkan hasil pengujian hipotesis dapat disimpulkan: nilai signifikan uji-t Perputaran Modal Kerja = 0,806 > 0,05 atau nilai  sebesar -0,251 < t tabel = 2,145 (α = 0,05/2; n-k-1), artinya bahwa H0 diterima dan Ha ditolak. Hasil uji regresi  linear sederhana Y = 887,154 - 0,002 X, pada analisis koefisien determinasi atau R Square sebesar 0,004 dimana hasil ini dapat dijelaskan bahwa Perputaran Modal Kerja memberikan pengaruh terhadap Current Ratio (Y) sebesar 0,4% sedangkan sisanya adalah sebesar 99,996% dipengaruhi oleh faktor lain. Saran sebaiknya penelitian yang akan datang meneliti semua jenis perusahaan yang terdaftar di Bursa Efek Indonesia dengan pengamatan yang lebih panjang atau meneliti variabel lain yang mempengaruhi current ratio seperti perputaran kas, perputaran persediaan dan perputaran piutang.
PENGARUH MEREK TERHADAP PROSES KEPUTUSAN PEMBELIAN PRODUK DI PT. SUAN BAKERY MEDAN
Authors: Halawa Hendisman , Br Sinulingga Nuriyanti Febrina
Published: May 2023

Merek merupakan suatu nama, simbol tanda desain atau gabungan diantaranya untuk dipakai sebagai identitas suatu perorangan, organisasi atau perusahaan pada barang dan jasa yang dimiliki untuk membedakan dengan produk jasa lainnya. Rumusan masalah dalam penelitian ini adalah apakah merek berpengaruh terhadap proses keputusan pembelian produk di PT. Suan Bakery Medan. Tujuan dari penelitian ini untuk mengetahui pengaruh merek terhadap proses keputusan pembelian di PT. Suan Bakery Medan. Hipotesis dalam penelitian ini adalah merek berpengaruh terhadap proses keputusan pembelian produk di PT.Suan Bakery. Penelitian ini menggunakan analisis uji regresi linear sederhana, uji determinasi, uji t. Jumlah sampel dalam penelitian ini adalah 82. Hasil penelitian menjawab rumusan masalah yaitu ada Pengaruh Aspek Merek Terhadap Proses Keputusan Pembelian Produk Di PT. Suan Bakery. Penelitian ini menunjukkan persamaan regresi dimana Y= 2,595+ 0,566 X yang artinya aspek merek memiliki pengaruh yang positif terhadap minat keputusan konsumen.

 

Dari hasil penelitian yang dilakukan diketahui hasil uji t dimana thitung = 8,767 sedangkan nilai ttabel =0,67757 sehingga thitung>ttabel yang artinya jika merek ditingkatkan maka minat konsumen juga akan meningkat. Maka kesimpulan dari penelitian ini adalah dari hasil uji koefisien determinasi pada R Sguare sebesar 0,490 hal ini menunjukkan bahwa minat beli konsumen 49% dipengaruhi oleh aspek merek dan sisanya 51% dipengaruhi oleh variabel lain diluar penelitian ini. Saran dari penelitian ini adalah akan lebih baik lagi jika aspek merek terus diterapkan dan ditigkatkan dengan disertai meningkatnya minat konsumen, karena karyawan PT. Suan Bakery akan memiliki peluang untuk menyalurkan kreativitasnya dengan ide merek yang lebih baik.
KEBIJAKAN KRIMINAL DALAM PENCEGAHAN DAN PENANGGULANGAN KEJAHATAN PERDAGANGAN MANUSIA (HUMAN TRAFFICKING) DI INDONESIA
Authors: Abadi Abadi , Yusuf Hambali , Mahfuz Abdul Latif
Published: May 2023

Kasus kejahatan perdagangan orang atau manusia merupakan kasus yang sangat serius dan seharusnya juga ditangani dengan cara luar biasa serta pelakunya dihukum dengan seberat-beratnya. Namun penanganan kejahatan ini bukanlah segampang membalikkan telapak tangan, karena faktor-faktor penghambat seperti peraturan perundang-undangan, aparat penegak hukum juga budaya serta kesadaran hukum masyarakat. Permasalahan penelitian ini adalah bagaimana kebijakan kriminal dalam pencegahan dan penanggulangan kejahatan perdagangan manusia (human trafficking) di Indonesia dan faktor-faktor apa yang menjadi penyebab terjadinya kejahatan perdagangan manusia (human trafficking) ditinjau dari perspektif kriminologis. Penelitian ini tergolong penelitian yuridis normatif. Sumber data yang digunakan adalah data primer dan data sekunder. Berdasarkan hasil penelitian ditemukan jawaban, bahwa kebijakan kriminal dalam pencegahan dan penanggulangan kejahatan perdagangan orang atau manusia di Indonesia dilakukan dengan menggunakan dua cara pendekatan, yaitu melalui sarana penal dan non penal dengan melakukan tindakan preventif dan represif. Adapun faktor yang menjadi pemicu terjadinya kejahatan perdagangan orang atau manusia adalah faktor kemiskinan, pendidikan, pengaruh sosial budaya, lemahnya system pencatatan dokumen kelahiran, kejahatan korupsi dan lemahnya penegakan hukum.
Բանաստեղծ գրականագետը (Վահագն Դավթյան – 100)
Authors: Քալանթարյան Ժենյա
Published: May 2023

Հոդ­վա­ծում քննութ­յան են առն­վում Վա­հագն Դավթ­յա­նի գրա­կան-քննա­դա­տա­կան հոդ­ված­նե­րը, ո­րոնք վե­րա­բե­րում են հայ և տար­բեր ազ­գե­րի գրող­նե­րի (բա­նաս­տեղծ­նե­րի) և պա­րու­նա­կում են ընդ­հան­րա­կան նշա­նա­կութ­յուն ու­նե­ցող տե­սա­կան հար­ցադ­րում­ներ։ Այդ հար­ցա­դրում­նե­րը վե­րա­բե­րում են պոե­զիա­յի էութ­յա­նը, ա­վան­դույ­թի և նո­րա­րա­րութ­յան անխ­զե­լի կա­պին, գրա­կա­նութ­յան ազ­գա­յին բնույ­թին, թարգ­մա­նութ­յան խնդրին և­ այլն։ Դավթ­յա­նի հոդ­ված­նե­րը երկպ­լան են, ո­րով­հետև մի կող­մից բա­ցա­հայ­տում են ան­հատ գրո­ղի ա­ռան­ձնա­հա­տուկ կող­մե­րը, մյուս կող­մից՝ գրա­կա­նութ­յան ընդ­հա­նուր օ­րի­նա­չա­փութ­յուն­նե­րը։

Դավթ­յա­նի գրա­կա­նա­գի­տա­կան հոդ­ված­նե­րի հետ սեր­տո­րեն առնչ­վում են ընդ­հան­րա­պես մշա­կույ­թի և­ ար­վես­տի տար­բեր ճյու­ղե­րի՝ նկար­չութ­յան, ե­րաժշ­տութ­յան, թատ­րո­նի ու ռե­ժի­սու­րա­յի, ճար­տա­րա­պե­տութ­յան ու քան­դա­կա­գոր­ծութ­յան վաս­տա­կա­շատ գոր­ծիչ­նե­րի դի­ման­կար­նե­րը՝ նրանց ար­վես­տի՝ նրբո­րեն դիտ­ված հատ­կա­նիշ­նե­րի ընդգծ­մամբ։ Ն­մա­նա­տիպ հոդ­ված­նե­րը հա­կա­դարձ է­ֆեկ­տով ստեղ­ծում են հենց Դավթ­յան ար­վես­տա­գե­տի դի­ման­կա­րը։
Մաս-ամբողջ հարաբերությունների լեզվական առանձնահատկությունները
Authors: Ներսեսյան Գոհար
Published: May 2023

Հոդ­վա­ծում դի­տարկ­վում են աշ­խար­հա­ճա­նա­չո­ղութ­յան հիմ­նա­րար հաս­կա­ցու­թյուն­նե­րից հա­մար­վող մա­սի և­ ամ­բող­ջի փի­լի­սո­փա­յա­կան կար­գե­րի լեզ­վա­կան դրսևո­րում­նե­րը: Վեր­ջին­ներս բնո­րոշ­վում են ի­րենց բարդ բնույ­թով և պայ­մա­նա­վոր­ված են ոչ մի­այն լեզ­վա­կան հա­մա­կար­գե­րի և դ­րանց տար­րե­րի հա­րա­բե­րակ­ցու­թյան խնդիր­նե­րով, այլև սույն լեզ­վա­տար­րե­րի կա­նո­նա­կարգ­ման և հա­մա­պա­տաս­խան հա­մա­կար­գե­րի մեջ կար­գա­դաս­մամբ: Անդ­րա­դարձ է կա­տար­վում լեզ­վա­կան տե­ղա­շար­ժե­րի օ­րի­նա­չա­փու­թյուն­նե­րի ըմբռն­ման հիմ­քում դրված ամ­բող­ջաց­ման և տար­ան­ջատ­ման գործ­ըն­թաց­նե­րին, ո­րոնք տար­րե­րի հա­րա­ցույ­ցա­յին ու շա­րույ­թա­յին զու­գոր­դում­նե­րի ար­դյունք են, ինչ­պես նաև՝ մաս-ամ­բողջ հա­րա­բե­րութ­յուն­նե­րի և լեզ­վա­կան մա­կար­դակ հաս­կա­ցութ­յան սերտ կա­պին, ո­րի մի­ջո­ցով միայն կա­րե­լի է բա­ցա­հայ­տել մաս-ամ­բողջ կա­ռույց­նե­րի ա­ռանձ­նա­հատ­կութ­յուն­նե­րը՝ ի­րենց ձևե­րի ողջ բար­դութ­յամբ:
Ayurvedic Approach Towards Wolf-Hirschhorn Syndrome: A Case Report
Authors: Anoop A S  , A A N Udaykumar
Published: May 2023

Wolf-Hirschhorn Syndrome is a rare chromosomal disorder caused by the partial deletion (structural aberration) of the short arm of chromosome 4. It is also known as 4P syndrome. The disease was first reported by Cooper, Hirschhorn and Wolf. The characteristic features of the patient depend on the extent of deletion of the genetic materials. The patient has craniofacial dysmorphism and the dysmorphic features are collectively known as Greek Warrior Helmet Facies. There is no direct correlation available for Wolf-Hirschhorn Syndrome in Ayurveda. Since it is a congenital pathology occurring due to chromosomal aberration it may be understood as a Sahaja vyadhi caused due to Beeja dosha. Here in this case the micro/partial deletion of genetic materials from short arm of chromosome 4 is due to the Beeja dosha that has occurred during the formation of Garbha (zygote). This Beeja dosha is responsible for the manifestation of different presentation in Wolf-Hirschhorn Syndrome which can be understood as a Vyadhi Sankara i.e., syndrome. The patient was presented with the features of facial dysmorphism, hypospadias, developmental delay and seizures. Hence the case was diagnosed as Vyadhija Phakka with Vataja Apasmara. In the present case the focus was mainly in the correction of developmental delay and to prevent the relapse of seizures. An integrated treatment protocol comprising Phakka chikitsa and Vataja Apasmara chikitsa were administered. Though there was no change in the facial dysmorphisms, but significant improvements were observed in the gross motor, language and communication milestones after the treatment.
Lifestyle vis-a-vis Anorectal Disorders
Authors: Gopal Singh  , Ajay Kumar Gupta
Published: May 2023

Ayurveda is science of life that aims at maintaining normal health of an individual along with treatment of various disorders. Appropriate Aahara (dietary habits) and Vihara (lifestyle) plays a vital role in maintaining normal health and also in treatment of various disorders along with the use of medication. In today’s era with rapid economic development there is an increase in irregular and inappropriate dietary habits and lifestyle, which are major reason for increase in a sedentary lifestyle and disturbed digestion (due to Mandagni) leading to occurrence of Gudagata Rogas (anorectal disorders) like Bhagandara (Fistula-in-ano), Arsha (haemorrhoids), Parikartika (fissure-in-ano), Guda Kandu (pruritis ani) etc. There disorders reoccur after sometime even after surgical intervention due to inappropriate Aahara (dietary habits) and Vihara (daily routine) of patients, so it’s very important to educate patients regarding Aahara and Vihara. In this article an effort is made to highlight a disciplined protocol in view of ancient Acharyas regarding appropriate Aahara and Vihara for a disease-free society.
Role of Pathya-Apathya in the Management of Prameha (Type-2 Diabetes Mellitus)
Authors: Mohit Sharma  , Prem Prakash Vyas  , Harish Kumar Singhal
Published: May 2023

Before starting management of any disease three important things to be kept in mind that is etiology, well planning, and Pathya-Apathya. Pathya–Apathya plays important role in the management of various disorders. Prameha is one of such disorder in which Pathya-Apathya affect its morbidity. Etiology, etiopathogenesis with clinical manifestation of Prameha are very well described in ancient textbook like Charaka Samhita, Sushruta Samhita, Astanga Hridyam and Astanga Samgraha etc. In all treatise of Ayurveda, Prameha is considered as Santarpanajanya Vikara that is of three types i.e., Vataj, Pittaj and Kaphaja. Madhumeha mentioned under the heading of Vataj Prameha that is closely correlated to diabetes mellitus. Diabetes Mellitus is of two type viz., Type-1 Diabetes & Type-2 Diabetes. Among that, Type-2 diabetes is non-insulin dependent diabetes mellitus that occur in middle age. In this clinical entity insulin resistance was developed. In its management, Pathya–Apathya contributes a major role in controlling blood sugar level. Therefore, author attempted to highlight role of Pathya–Apathya (do’s & don’t) in the management of Type-2 Diabetes Mellitus.
Review of the Plant Jalapippali (Phyla Nodiflora) - An Under Exposed Plant
Authors: Savita  , Jayashree
Published: May 2023

Ayurved provide a strong base for utilization of a large number of plants in general healthcare as well as alleviation of diseases. Jalapippali which is identified as Phyla nodiflora L. Greene syn Lyppa nodiflora, family Verbinaceae, is found in most of the states throughout India at riverbanks, along lakes and near fresh water bodies. Jalapippali has been explained in most of the Nighantus in Ayurved. Aim: the study aims to review the under exposed plant Jalapippali from available classical texts and modern sources to highlight its therapeutical importance. Methods: The study covers to summarize the literature in the available Ayurved classical texts while identifying the potential areas for further development of this herb for therapeutical uses in the field of Ayurveda. Result: Even though very fewer references are available in Ayurved-Brihatrayee, but during the Nighantu period most of the Nighantus have highlighted its therapeutical importance. The references are available even in the oldest Nighantu- Dhanwantatari, and many researchers suggest, the plant is rich in many important medicinal useful compounds. And the plant contains a variety of constituents such as triterpenoids, flavonoids, phenols, steroids, etc. The plant is having significant antimicrobial, anti-inflammatory, antidiuretic etc. activities. Conclusion: Jalapippali is one of the important plants. Especially the Nighantus have highlighted its importance. The recent studies suggest its pharmacological values. Hence further clinical studies should be carried out for its therapeutical values. And also, the Jalapippali mentioned in Brihatrayees has to be explored for its botanical identification so as to redefine its clinical importance.
Ayurvedic Management of Diabetes Mellitus (DM) and Diabetic Neuropathy: A Case Study
Authors: Vishal Mori  , Manish Patel  , S N Gupta  , Pankaj Chhayani
Published: May 2023

Diabetes is a burning problem of modern world and is associated with multiple complications. All oral hyoglycemic drugs and insulin used in modern medicine only help to lower blood sugar of body. The biological medicines are only available treatments which have limited effect and carrying many serious adverse effects. Purpose: The conventional medicine has its own limitation in this disease condition, it only help to lower blood sugar level of body and in a long run it has shown its side effects. They neither able to correct the pathology nor helpful to protect vital organs of the body and to prevent further complications. Ayurvedic treatment approaches are helpful in this disease. With the changing demand and awareness among these days, the role of Ayurveda is an emerging reality. Brief case history: A 49-year-old, married, Hindu male patient visited PD Patel Ayurvedic Hospital on 9th November 2021. He had been diagnosed with type 2 diabetes above 11 years and received medication for this. He was taking Tab. Metformine since last 11 years. He had chief complains of Madhuryamasyata, Karapadadaha, Pipasadhikya, Mootraadhikya since last 11 years, and other associated complains were Kshudha Vriddhi, Atichinta, and Nidravriddhi since last 4 months. He had gradually increased body weight in last year 2 years. He had been admitted and treated with Virechna karma and Basti chikitsa and oral Ayurvedic medicines for one month. After one month of treatment, he is continuing oral medicines only and he regularly comes for following up in OPD. Now on the second follow up patient had much improvement in above symptoms. His blood sugar level and weight were also reduced significantly. Result: He got an excellent result with complete relief from all symptoms as well as marked reduction in objective criteria (lab investigation) within 1 month.
Glimpses of Patala (Stereospermum Suaveolens roxb. Dc.) in Rasashastra: A Review
Authors: Parkhi Vishwatej V  , Dabhi Swati P  , Pandya Matangee H  , Patel Bhupesh R
Published: May 2023

In the universe of Ayurveda, Patala (Stereospermum suaveolens Roxb. DC.) is renowned drug credited with variety of therapeutic properties as well as other specific uses. It is also the member of much celebrated Mishraka Varga like Bruhatpanchmoola and Dashmoola. Rasashastra i.e., Indian alchemy or Iatrochemistry deals primarily with metals, minerals, gems etc. but it is inseparable from different flora and fauna. This sincere attempt helps ease out the efforts to draw information on Patala, Bruhatpanchmoola and Dashmoola from Rasashastra domain. For this purpose, information pertaining to Patala and other two herbal groups was screened from classical Rasashastra texts available at central library of ITRA, Jamnagar. Gathered information according to relevance and specificity was arranged in tabular form under the headings like name of group, processes like Shodhana, Marana, formulation name, mode of administration, dosage form etc. Total 18 groups of herbs, 164 formulations (excluding references of processes like Shodhana/Marana) were found having their therapeutic efficacy in almost 28 indications with 14 dosage forms at their disposal. Dashmoola in formulations, Jvara in therapeutic indications and Rasaushadhi in dosage forms were found in majority. Lastly general information of Patala, in the context of Dinacharya, Rutucharya, Rasashala, its simile also quoted. This review depicts multimodal applications of Patala along with its group of herbs in Rasashastra. The write-up will serve as in hand guide for the knowledge of Patala and its associated groups of herbs in the branch of Rasashastra.
Ayurvedic Management of Kaphaja Yonivyapada (Trichomonas Vaginitis) - A Case Report
Authors: Jyoti Thakur  , Soni Kapil
Published: May 2023

Yoni Srava is an annoying symptom that usually reflects infective conditions of genital tract in females. One of the Yonivyapada having Yonisrava as its prominent symptom is Kaphaja Yonivyapada which can be co-related to Trichomoniasis or Candidiasis infections. In Kaphaja Yonivyapada, symptoms of itching along with sticky and unctuous discharges per vaginum have been illustrated. The patient may experience either mild and dull pain or no pain at all. In severe Trichomonas infection, there is mild to moderate pain at the genital organs due to inflammatory changes, though in most cases, it may be painless. Considering all the symptoms, mentioned by Acharya Charaka and others, the Kaphaja Yonivyapada can be closely compared with Trichomonas Vaginitis. A 46 years old female patient was presented with the complaints of itching in vulvar region and white discharge per vaginum since 3 months. On clinical evaluation, ulceration was present on bilateral labia minora along with strawberry spots on vaginal walls, yellowish-white discharge and cervical congestion. Aim and Objective: To study the efficacy of Sthanik Chikitsa along with oral Ayurvedic formulations in Kaphaja Yonivyapada (Trichomoniasis). Nimbadi Kshaya Yoni Dhavan followed by Mahanimba Taila Pichu twice a day for seven days along with oral herbal formulation is prescribed to the patient. Results: After completion of the treatment protocol patient got relief in her symptoms like itching in vulvar region and white discharge per vaginum. Conclusion: In Kaphaja Yonivyapada, especially Trichomonas Vaginitis Ayurvedic management by the use of Mahanimba (Melia azedarach) containing formulations for Sthanik Chikitsa are quite effective as Mahanimba is having Krimighna and Kandughna properties.
A Case Study on OPD Level Management of Infertility due to PCOS with Ayurvedic Medicines
Authors: Anila.M  , Sruthi L.R
Published: May 2023

PCOS is the primary cause of Hyperandrogenism and oligo-ovulation at the reproductive age and is often associated with infertility. The prevalence of infertility in women with PCOS varies between 70 and 80 %. In Ayurveda, Vandhyatva is considered as one among the Rasa pradoshaja vikaras. This is case report of an infertile couple who had not been able to conceive since 4 yrs. The wife was diagnosed with PCOS. Based on the parameters of Ayurvedic science this case was diagnosed as Vandhyatva (infertility) due to Nashtarthava (PCOS). The treatment plan for PCOS is to correct the menstrual irregularity and ensure proper ovulation, this itself helps to develop healthy progeny and successful childbirth. The treatment principles selected here were mild Shodhana and Samana therapy especially Vatakaphahara, Agni deepana along with Pathya ahara. After two and half month of internal medications, reduction in abnormal hair growth, blackish discolouration and weight were noticed. The outcome of the treatment resulted in natural conception and delivered a full term male baby. So this case signifies effect of Ayurvedic science in the management of infertility.
What happened in Digital and Computational Pathology at the European Congress of Pathology, Basel, 2022?
Authors: Zlobec Inti , Polonia Antonio , Treanor Darren , van der Laak Jeroen
Published: May 2023

The WG Digital & Computational Pathology, formerly called the WG IT (Computational) enjoyed an active presence at the 34th European Congress of Pathology (ECP) 2022 in Basel. Whether tackling the important question of “AI: useful or useless” in different disease entities, to a live demonstration of “AI in the wild” during the hugely popular Computational One-Day Symposium, or discussing critical aspects of quality management and ethics at the AI Taskforce meeting, the presence of digital and computational pathology could certainly be felt. Importantly, abstracts for poster sessions and oral free papers were abundant, highlighting the increasing relevance and interest of these topics for pathologists across Europe and beyond. Here, we give a short report on the activities connected to digital & computational pathology at the ECP.
Deep-learning-based interpretability and the ExaMode project in histopathology image analysis
Authors: Müller Henning , Atzori Manfredo
Published: May 2023

With digital clinical workflows in histopathology departments, the possibility to use machine-learning-based decision support is increasing. Still, there are many challenges despite often good results on retrospective data. Explainable AI can help to find bias in data and also integrated decision support with other available clinical data. The ExaMode project has implemented many tools and automatic pipelines for such decision support. Most of the algorithms are available for research use and can thus be of help for other researchers in the domain.
Designing a gingerbread product based on gluten-free vegetable compositions
Authors: Rysmukhambetova G. E. , Beloglazova K. E. , Ushakova Yu. V. , Ziruk I. V.
Published: May 2023

The research is devoted to the creation of a new recipe and technological solutions for the production of gluten-free gingerbread products for people who need dietary nutrition. Our studies were carried out in accordance with GOST 15810-2014 «Confectionery products. Gingerbread products. General specifications». Based on marketing research, it has been established that nowadays production of gluten-free confectionery products, including gingerbread ones, is underdeveloped in the region. The following samples of gingerbread products are considered in the research: the control one – 100% wheat flour; No. 1 – 50% rice and 50% corn flour; No. 2 – 50% corn and 50% pumpkin flour. As a result of the experiments, sample No. 1 with the best organoleptic characteristics has been selected. The gluten level in the gingerbread product under study was calculated, and it amounted to 7 mg/kg, which according to TR CU 027/2012 was lower than the normalized value (20 mg/kg). Therefore, this product belongs to the «gluten free» product group. It has been established that due to the high water absorption capacity, the introduction of mixture No. 1 into the food industry is relevant, since there is a greater rise in the dough during baking and less thickening of starch grains. As a result of our calculations of the chemical composition of this product, it has been found that through the use of an alternative type of raw material, it is possible to design products with various contents of food and biologically active substances, including a vitamin–mineral complex, which are not inferior in their characteristics to traditional products made from wheat flour. Thus, the studies conducted have shown that the use of non-traditional types of raw materials (rice and corn flour) allows one to make gluten-free products with high quality indicators, including organoleptic, structural-mechanical properties and enriched in nutritional value.
Humic preparations in the Macleaya х kevensis Turill cultivation in the conditions of the Western Caucasian region
Authors: Bykova O. A. , Tkhaganov R. N. , Tkhaganov R. R. , Anikina A. Y.
Published: May 2023

Over the past years highly effective phytopreparations with antibacterial activity have been created in Russia. Macleaya x kevensis Turill, which is a hybrid between heart-shaped Macleaya (Macleaya cordata) and small-fruited Macleaya (Macleaya microcarpa), can serve as a raw material for their production. To provide the pharmaceutical industry with this type of raw material in the conditions of the North Caucasian branch of VILAR, plantations of this crop have been created and research is being carried out to create a zonal technology for its cultivation. The basis of cultivatiov is the exogenous regulation of the processes of growth, development and bioproductivity of the plant organism through the use of organomineral and microfertilizers. In 2019–2022 experiments on testing humic fertilizers (Potassium Humate, Lignohumate) and their complexes with silicon-containing microfertilizer Siliplant were carried out on the Macleaya plantation. Treatments with these preparations were carried out: in the 1st year of the growing season – at the beginning of regrowth and after 30 days, in the 2nd and 3rd years of the growing season – at the beginning of the growing season and after the first harvesting of raw materials for growing plants. As a result of the tests, an increase in the growth and development of Macleaya plants was observed. The activation of growth processes contributed to an increase in crop yield in the first year with a single cut by 0.18–0.19 t/ha (17–18%), in the 2 and 3 years of the growing season by the sum of two cuts by 1.50–1.76 t/ha (20–24%) and the collection of alkaloids per hectare by 21–27%.
Overview of gait rehabilitation in stroke
Authors: Sana Khalid  , Arshad Nawaz Malik  , Furqan Ahmed Siddiqi  , Farooq Azam Rathore
Published: May 2023

Stroke is the 2nd leading cause of death globally after ischaemic heart disease and is expected to rise more by 2030. The estimated incidence of stroke in Pakistan is about 250/100,000 individuals. Difficulty in walking is present in approximately 80% of stroke survivors. About a quarter of stroke survivors, even after receiving rehabilitation have residual gait impairments requiring assistance in activities of daily life. Almost half of stroke patients after being discharged will have episodes of fall, with majority of these falls occurring in activities like “turning”. Gait is one of the key features to participate in community and occupational activities. Therefore, appropriate gait rehabilitation post stroke is crucial for functional independence and community ambulation. There are many approaches to gait rehabilitation based on different models of motor physiology and disease.  Augmenting conventional therapies with novel techniques such as utilization of electromechanical means have improved gait rehabilitation in improving functions. The usage of technology in rehabilitation of patients with neurological deficits, is still novel in Pakistan. This review provides an overview of advancements in neurological and gait rehabilitation post stroke.

Keywords: Cerebrovascular accident, gait, muscle strength, rehabilitation, robotics, virtual reality.