bluuebunny/crossref_metadata_2025 huggingface dataset:
Atorvastatin inhibits inflammation through the cysteine-rich motor neuron 1 (Crim1) pathway in human umbilical vein endothelial cells
Authors: Liu Xuehui , Wu Changmeng , Wang Shuyuan , Dong Xianhui , Li Xueheng , Bei Yanrou , Song Yu , Wu Limei , Liu Huasen , Liu Dabin , Wu Shaoguo , Hu Yanwei
Published: January 2024

Background and AIMS: Inflammation has been recognized to have a role in
the process of atherosclerosis. Although evidence indicates that
atorvastatin has anti-inflammatory effects besides cholesterol-lowering
ability in atherosclerosis, the specific mechanisms of atorvastatin in
inflammation requires further discussion. METHODS: Here, we explored the
effects and mechanisms of atorvastatin on inflammation in human
umbilical vein endothelial cells through quantitative real-time PCR and
western blot analyses. In addition, microarray analysis and
immunohistochemistry were used to analyze the expression of Crim1 in
atherosclerotic plaques. RESULTS: Cysteine-rich motor neuron 1 (Crim1)
mRNA was upregulated 36.68 fold (P<0.001), and Crim1 protein
was upregulated 3.63 fold (p<0.001), in human atherosclerotic
plaques compared with normal intima tissues. Bioinformatics analysis
revealed Crim1 co-expression with IL-6, TNF-α and NF-κB. Atorvastatin
dramatically downregulated the mRNA and protein levels of Crim1 and
inhibited inflammation by decreasing the levels of IL-6, TNF-α and
NF-κB. Knockdown of Crim1 significantly inhibited IL-6, TNF-α and NF-κB
expression, whereas overexpression of Crim1 upregulated IL-6, TNF-α and
NF-κB expression. In addition, the inhibitory effects of atorvastatin on
inflammation were markedly offset by overexpression of Crim1.
CONCLUSION: These results demonstrated that atorvastatin
decreases inflammation via the Crim1 pathway in HUVECs, thus, providing
a new prospect for the use of atorvastatin for non-lipid lowering
functions, and new directions for the prevention and therapy of
atherosclerosis.
Effects of Benzalkonium Chloride in Children with Asthma Receiving Nebulized Continuous Albuterol
Authors: Kennedy Amy , Murray Tristan , Elder Kimberly , Olmstead Lindsay , O'Hagan Adrian
Published: January 2024

Objectives: Compare treatment length of continuous albuterol
nebulization, hospital length of stay, and respiratory outcomes for
pediatric patients with status asthmaticus treated with benzalkonium
chloride-containing continuous albuterol nebulization (BAC-albuterol)
versus preservative-free continuous albuterol nebulization
(PF-albuterol). We hypothesized use of PF-albuterol results in decreased
treatment duration, hospital length of stay, and improved respiratory
outcomes when compared to the BAC-albuterol. Methods: Retrospective
chart review of patients admitted for status asthmaticus during two time
periods that corresponded with two different albuterol formulations,
BAC-albuterol (October 2017-February 2018) and PF-albuterol (October
2018-February 2019). Patients eligible for analysis included those 3 to
17 years of age initiated on continuous albuterol nebulization for
treatment of status asthmaticus. Patients were excluded if admitted for
an alternative primary diagnosis, received terbutaline, or received
continuous albuterol nebulization through a ventilator. Results:
One-hundred patients received BAC-albuterol and 84 patients received
PF-albuterol. There was no significant difference demonstrated in
treatment duration of BAC-albuterol and PF-albuterol (median 14.9 hours
vs 17.5 hours, respectively; p = 0.385). Patients treated with
PF-albuterol had significantly decreased requirements for oxygen
escalation, as well as escalation of other pharmacologic treatment,
during continuous albuterol nebulization. Conclusions: There were no
significant differences in time on continuous albuterol nebulization or
hospital length of stay between groups. However, high-flow oxygen
requirements, as well as pharmacologic escalation, during continuous
albuterol nebulization were significantly decreased with PF-albuterol.
Prospective data may help further discern the impact of BAC-albuterol on
clinical outcomes for pediatric patients admitted for treatment of
status asthmaticus.
Antimicrobial use and its association with the presence of methicillin-resistant staphylococci (MRS) and extended-spectrum beta-lactamases (ESBL)-producing coliforms on dairy farms in Chiba Prefecture, Japan
Authors: Sugiura Katsuaki , Kikuchi Masato , Okabe Takuma , Shimizu Hideshige , Matsui Takashi , Matsuda Fuko , Haga Takeshi
Published: January 2024

Food-producing animals, including dairy cattle, have been described as
potential reservoirs of antimicrobial resistance. However, data remain
scarce on the antimicrobial use and the selection of resistant bacteria.
We investigated the association between antimicrobial use and resistance
of mastitis pathogens, using data from 134 dairy farms in Chiba
Prefecture, one of the major dairy production prefectures in Japan. Milk
samples were collected from cows with mastitis in 2016. We recorded
antimicrobial use and any isolation of methicillin-resistant
staphylococci (MRS) and extended-spectrum beta-lactamase
(ESBL)-producing coliforms. The number of treatment days (TDs) was used
as an indicator of the antimicrobial use on each farm. Farms in which
either MRS or ESBL-producing coliforms were isolated from at least one
mastitic milk sample were defined as an AMR positive farm. Farms from
which neither MRS nor ESBL-producing coliforms were isolated were
defined as AMR negative farms. The results revealed that the AMR
positive farms had a significantly higher number of TDs (median value of
16.49) compared to AMR negative farms (median value of 14.02),
suggesting that dairy cattle might be a source for the transmission of
resistance genes and/or resistant bacteria between cattle and/or to
humans.
One-time seed addition promotes long-term recovery of plant diversity and productivity in a previously fertilized old field
Authors: Portales-Reyes Cristina , Ebel Carmen , Clark Christopher , Isbell Forest
Published: January 2024

Unassisted recovery of plant diversity after reductions in nutrient
inputs can be slow and incomplete. Increased nutrient availability,
light limitation and recruitment limitation are thought to be primary
barriers to diversity recovery. In a full-factorial experiment, we
tested whether removing these obstacles promoted recovery of plant
diversity in a previously cultivated and fertilized old-field. Results
immediately following manipulations demonstrated that these factors
increased diversity to varying degrees, but it was unknown whether these
restorative processes would continue or diminish over time. Here, we
examine long-term responses 13 years after these manipulations and find
that seed addition was the only treatment that continued to increase
plant diversity and productivity. Seed addition also reduced the biomass
of two invasive species that become co-dominant in this grassland after
sufficient nutrient inputs. Our results suggest that alleviating
recruitment limitation can accelerate the recovery of plant diversity,
and ecosystem functions that depend on plant diversity.
Omalizumab for the Treatment of Allergic Rhinitis: A Systematic Review and Meta-Analysis
Authors: Tsabouri Sophia , Ntritsos Georgios , Koskeridis Fotios , Evangelou Evangelos , Olsson Petter , Kostikas Kostas
Published: January 2024

Background: Allergic rhinitis (AR), an IgE-mediated inflammatory
disease, significantly impacts the quality of life of a considerable
proportion of the general population. Omalizumab, a humanized monoclonal
antibody against IgE, has been evaluated for both seasonal and perennial
AR. We aimed to assess the efficacy and safety of omalizumab in
randomized controlled trials (RCTs) in inadequately controlled AR.
Methods: We conducted a systematic literature search of RCTs evaluating
the safety and efficacy of omalizumab in AR. We synthesized evidence for
clinical improvement of AR symptoms, quality of life, reduction of the
use of rescue medication, and adverse events. Results: The systematic
search returned 289 articles, of which 12 RCTs were eligible for data
extraction and meta-analysis. Omalizumab reduced the Daily Nasal Symptom
Severity Score (DNSSS) by a summary standardized mean difference of
-0.41 points (95% CI: -0.61, -0.22; I2=93.2%), the Daily Ocular
Symptom Severity Score (DOSSS) by a summary standardized mean difference
of -0.30 points (95% CI: -0.50, -0.01; I2=86.2%), the
Rhino-conjunctivitis Quality of Life Questionnaire by a summary
standardized mean difference of -0.45 points (95% CI: -0.57, -0.34;
I2=0%) and the mean daily consumption of rescue antihistamines by a
summary standardized mean difference of -0.21 (95% CI: -0.41, -0.01;
I2=85.7%). No statistically significant difference in the occurrence of
adverse events was observed between omalizumab and placebo (Relative
Risk 1.03; 95% CI: 0.93, 1.14; I2=43.3%). Conclusion: Our findings
further support the efficacy and safety of omalizumab in the management
of patients with allergic rhinitis inadequately controlled with
conventional treatment.
High-grade Ovarian Adenosarcoma with Heterologous elements Arising from Recurrence of Benign Mucinous Cystadenoma: a rare child case and brief review of the literatures
Authors: Li Jiwei , du rui , Zhang Li , Jiang Hongchao , chen shaoyu , Shu Hong
Published: January 2024

Female reproductive organ tumors commonly occur in the uterus of adult
and postmenopausal women, but rarely in the extra-uterine of children
and adolescents. Especially, benign tumor recurrence and transformation
into malignant tumor with metastasis, is extremely rare. We report a
special case of a girl who had been diagnosed as mucinous cystadenoma
for the first time, recurred as high-grade adenosarcoma after the first
operation, and developed distant metastasis after the second operation
and chemotherapy. The clinic history, imaging and pathology of the case
are very characteristic, and require us to find more rational
therapeutic methods.
An Unusual Case of Late Recurrence of MS Neuroblastoma in a Young Adult
Authors: Boulter Alexis , Watt Tanya
Published: January 2024

This case describes an unusual presentation of a young adult with very
late recurrence of stage MS neuroblastoma over 20 years after initial
diagnosis. Tumor histology at relapse demonstrated ganglioneuromatous
foci within her undifferentiated tumor. In combination with evidence of
altered catecholamine metabolism, it proposes a case for
dedifferentiation of unresected ganglioneuromatous lesions as the
etiology of her recurrence of disease. An additional, compelling
component of the case is the overall positive treatment response of the
patient with relapsed neuroblastoma despite the poor prognostic factors
of late relapse and adult age.
Advances in designing Next-generation drugs from Natural products
Authors: SJ Aditya Rao , Shetty Nandini Prasad
Published: January 2024

With developments in contemporary medicinal practices, though the focus
on natural product drugs are fading, their effects remained
unquestionable. Due to the complex mechanism of action, though their
applications might have reduced in recent decades, their utilization is
still at a greater side compared to any other medicinal practices in the
world. The present review details some of the advancements in the
development of effective natural product drugs as novel therapeutics
with the implementation of modern drug discovery tools. The
developmental prospects in Natural Product research with the
implementation of some of the emerging trends in information technology
like big data, automation, artificial intelligence (AI), computer-aided
drug design and omics strategies along with the allied techniques in
medicinal chemistry, nanotechnology, combinatorial chemistry and
high-throughput screening are discussed. The review particular focuses
on the development of innovative techniques, new methodologies and
interdisciplinary applications with future prospects as well as
impending goals.
Engineering Pt1-Al2O3 enhances catalytic performance of naphtha reforming
Authors: Li Panpan , Yang Yanpeng , Gao Denglei , Lu Fei , Yi Ding , Zhou Bo , Liu Shoujie , Nie Ji , Li Mingzhe , Du Yuting , Xu Yong , Li Sha , Wang Xi , Yao Jiannian
Published: January 2024

Pt nanoparticle with high Pt-Pt coordination number and degenerate d
orbitals, has a strong affinity to naphtha and relevant intermediates,
leading to severe carbon deposition and catalyst deactivation during
naphtha reforming. The catalytic performance of Pt catalyst could be
finely tuned by tailoring its d-electron structure. Herein, we propose a
straightforward chlorinating strategy to transform PtOx nanoparticle
into Pt single atoms with a specific Cl-Pt-O coordination. The
adsorption of benzene on Pt is weakened with the Cl-Pt-O coordination,
which facilitates aromatics desorption and hampers carbon deposition.
Density functional theory (DFT) calculation indicates that the z-axis of
Pt 5d orbitals is occupied and selectively exposes xy-plane orbital (dxy
and dx2-y2), which weakens d-π hybridization between Pt 5d orbitals and
π orbital of benzene ring. The d-electron regulation through
chlorinating is a readily scalable strategy to synthesis single atom
catalysts, and optimize naphtha reforming catalytic performance.
Extraction of Blood Biomolecules by Adsorption onto Silica Adsorbents
Authors: Boudia Hidayat , Mokhtari Mustapha , Hamaizi Hadj
Published: January 2024

Extraction tests of blood biomolecules such as glucose, urea and
triglycerides are carried out by simple contact of plasma with porous
silica samples. Amorphous silica materials are prepared from a sol-gel
method using a nonionic surfactant molecule as an organic source and
silica source in a strongly acid medium. The porous texture of the
solids allows the trapping of biomolecules and significantly reduces
their concentration in blood by simple prolonged contact. Adsorption is
therefore an efficient method that leads to blood purification when the
concentration of biomolecules is very high in the blood.
Gene-driving management practices in the dromedary husbandry systems under arid climatic conditions in Algeria.
Authors: HAREK Derradji , Mokhefi Mhamed El , Ikhlef Hacene , Bouhadad Rachid , Sahel Hocine , djellout noreddine , Arbouche Fodil
Published: January 2024

ABSTRACT Changes in socio-economics, demography, politics and climate in
arid and semi-arid regions in recent decades have led to profound
transformations in livestock practices particularly in the management of
local animal resources. The dromedary Camelus dromedarius has always
played an important role in human life history in Algeria; it provides a
substantial contribution in protein production such as milk and meat,
and it is used as means of transportation to local populations. It is
well adapted to arid environments and has a satisfactory potential for
food production that enables economic security to locals especially in
the context of climate change. Data concerning this valuable resource is
scarce. This article adds supplementary yet valuable information to the
current knowledge on camel genetic diversity related to different
management practices. Genetic and phenotypic variations and the
underlying raising systems’ practices are studied to understand
differences between breeds for a better resource management. The survey
of 277 camel breeders across the Algerian desert revealed a genetic
diversity in terms of breeds driven by four pastoral practices.
According to coat color and morphological aspect, the camel population
“Tergui” corresponds to tree breeds, namely Mahri with 53.13% of the
population, Marouki (43.22%), and the single-ecotype Azerghaf (3.65%).
Mahri is a mixture of Amelal and Abahou ecotypes that are being
outnumbered by Marouki’s ecotypes (Atelagh and Alemlagh).This
biodiversity is under real threat because of the behavior of pastoral
societies that pushes breeders to turn to breeds with a high market
value. Several useful conservation methods, including the use of modern
farming systems, could be positively used and/or improved, in order to
protect the genetic variety and help breeders realize a good living out
of it. Keywords: Algerian desert; arid area; C. dromedaries; genetic
diversity; management practices, typology.
The efficiency of recombinant vs. urinary gonadotropin in women of advanced reproductive age
Authors: Wang Ya , Lin Xiao , Zhang Jun , Zhao Yuan , Fu Yu , Bai Xiao , Qi Jun , Wang Ji , Yuan Hai , Hu Rong , Sun Qing
Published: January 2024

Purposes: The following study was conducted to determine the efficiency
of recombinant vs. urinary gonadotropin in women of advanced
reproductive age. Materials and Methods: In our study,we retrospectively
compared three ovarian stimulation regimens,HMG(n=199),uFSH(n=198),and
rFSH(n=103), in the treatment of 500 infertile women≥35 years old who
were subjected to in vitro fertilization/intracytoplasmic sperm
injection cycles during a gonadotropin-releasing hormone (GnRH)
antagonist protocol. Results: Overall, the mean number of retrieved
oocytes was lower in the HMG group compared with uFSH and rFSH
groups(P=0.000),while the clinical pregnancy per started cycle
(P=0.367), implantation and live birth rate per started cycles were not
significantly different.Data were further analyzed by performing
separate comparisons of subpopulations in different age range groups,
i.e.,35-37,38-40,and>40. Major differences between the
three regimens were observed in women who were older than 40 years of
age.In this subpopulation,not only the implantation rate was higher in
the uFSH group compared with HMG and rFSH groups (P<0.05), but
the live birth rate was also significantly higher (P<0.05).In
addition,the cost-effectiveness ratio was $434.2 in HMG group,
$2,331.1 in uFSH group and $3,284.5 in rFSH group. Conclusions: In
women aged 35-39, three gonadotrophins showed no differences in
pregnancy outcomes,however,HMG is less expensive and worth
recommending.In addition,the implantation rate and live birth rate
showed a tendency toward improvement in the woman of advanced
reproductive age (age>40) in the uFSH group compared with
HMG and rFSH groups.Similarly, this more beneficial effect was also
reflected in people with AFC<5.
Evaluation of Lung Functions in Preschool-Children Diagnosed with Transient Tachypnea of the Newborn by Impulse Oscillometry System
Authors: Çevik Ismail , ER İlkay , Günlemez Ayla
Published: January 2024

Background: Transient tachypnea of the newborn (TTN) is the most common
self-limiting respiratory distress in neonates. There are increasing
data suggesting that TTN may be a risk factor for childhood disease.
Aim: To evaluate lung functions in preschool-children diagnosed with TTN
using Impulse Oscillometry System (IOS) for the presence of respiratory
morbidity. Methods and Patients: In this prospective study,
preschool-children diagnosed with TTN and age-matched healthy children
were defined as TTN-group and control group, and performed IOS.
Resistance (R5-R20), reactance (X5-X20) resonant frequency (Z5), and
reactance area (AX) IOS values were compared in both groups and in
TTN-subgroups. Statistical findings were presented as median (IQR).
Results: A total of 51 preschool-children and 101 healthy controls
participated in study. The rate of asthma diagnosis and wheezing attacks
in TTN-group was found 30.8% and 38.5%, respectively. However, R5
minus R20 was significantly higher, X10, X15 values were significantly
lower in TTN-group than those in controls. Additionally, R5 minus R20
and AX values were significantly higher in late-preterm TTN-subgroup as
compared to term TTN-subgroup. AX was significantly higher in TTN-group
supported with nasal ventilation. R5, R10, R15 and R20 were
significantly higher in TTN-subgroup with history of maternal asthma
compared to TTN-subgroup without that history. R5, R10, R15 and Z5 were
significantly higher and X10, X15, X20 were significantly lower in
TTN-subgroup with passive smoking compared to TTN-subgroup without
passive smoking. Conclusion: Our findings showed peripheral airway
obstruction, a known finding in asthma, among preschool-children
diagnosed with TTN compared to healthy controls.
Postpartum urinary incontinence – types, prevalence, and risk factors before, during, and after pregnancy and childbirth: a prospective cohort study
Authors: Jansson Markus , Franzén Karin , Tegerstedt Gunilla , Hiyoshi Ayako , Nilsson Kerstin
Published: January 2024

Objective To assess the extent to which delivery mode and
antepartal and postpartal risk factors increase the risk of postpartum
stress and urge urinary incontinence. Design Prospective cohort
study. Setting Women registering at the maternity health care
service in Region Örebro County, Sweden. Population A total of
670 women. Methods Outcome measures were based on
questionnaires in early and late pregnancy and at 8 weeks and 1 year
postpartum. Generalized linear models were used. Main Outcome
Measures Significant stress and urge urinary incontinence at 1 year
postpartum in women who were continent before pregnancy.
Results Stress and urge urinary incontinence were reported by
21% and 8%, respectively, at 1 year postpartum. Vaginal delivery
increased the risk of stress (aRR=2.63 [95% CI: 1.39, 5.01]) but
not urge incontinence. This effect of vaginal delivery on stress
incontinence was similar irrespective of incontinence status during
pregnancy. The population attributable fraction of stress incontinence
associated with vaginal delivery was 0.58 (95% CI: 0.23, 0.77).
Conclusions This study shows essentially different risk factors
for stress and urge urinary incontinence, supporting stress incontinence
as being the subtype mostly associated with pregnancy and childbirth. At
population level, vaginal delivery was the major risk factor for stress
incontinence, but preventive use of caesarean section for this matter is
debatable. Funding ALF funding from Region Örebro County (Grant
Nos. OLL-930507 and OLL-939402) and Örebro University Hospital Research
Foundation (Grant No. OLL- 410421). Keywords Postpartum urinary
incontinence, stress urinary incontinence, urge urinary incontinence,
risk factors, prospective, cohort study
Knowledge regarding the development and acceptability of male contraceptives among Jordanian pharmacists: A Mixed sequential Method
Authors: Barakat Muna , Thiab Samar , Thiab Sarah , Alqudah Raja'a , Akour Amal
Published: January 2024

Rationale, aims, and objectives Community pharmacists have a crucial
role in providing comprehensive patient education regarding
contraception methods. This study aims to investigate Jordanian
pharmacists’ knowledge and perception towards male OCPs. Methods A
mixed-explanatory sequential method was divided into two phases. The
first was a self-administered electronic survey to community
pharmacists/trainees in Jordan. The second phase was carried out through
online semi-structured in-depth interviews targeting the maximum
variation purposive sample of community pharmacists. Results A total of
158 (response rate 98%) questionnaires were included in the analysis.
The majority of the participants were female (n=118, 74.2%). In terms
of knowledge, only 25% of participants acknowledged the presence of
male OCPs and almost half were uncertain about the mechanism of action
and the possible uses. The findings of the interviews confirmed the
relatively negative perception towards males OCPs. As, the identified
barriers to male OCPs were cultural norms, side effects, and poor
compliance. Conclusion There is a negative perception towards male OCPs,
as the majority of pharmacists believe such products will not be
successful in Jordan. Once these pills are approved for their
effectiveness and safety, men may need further education and
encouragement to take an active role in family planning along with their
partners.
Molecular Mimicry Study Between Peptides of SARS-CoV-2 and Neutrophil Extracellular Traps Related Proteins
Authors: Adiguzel Yekbun
Published: January 2024

Background. Neutrophil extracellular traps (NETs) are observed in both
COVID-19 pathology and autoimmune disorders, and molecular mimicry is a
mechanism that can lead to autoimmune response. Methods. Accordingly,
homologous sequences between SARS-CoV-2 proteins and 5 proteins
(plasminogen receptor KT: PLRKT, myeloperoxidase: MPO, proteinase 3:
PR-3, neutrophil elastase: NE, matrix metalloproteinase 9: MMP-9) that
are present in NETs, are searched. Human and SARS-CoV-2 sequence pairs
are identified. Those among the identified sequence pairs, which are
strong-binding peptides or epitopes of the same HLA alleles, are
predicted. Results. PLRKT and SARS-CoV-2 similar peptides with high
affinities to HLA-A*24:02, HLA-B*08:01, and HLA-B*15:01; MPO and
SARS-CoV-2 similar peptides with strong affinities to HLA-A*01:01,
HLA-A*26:01 and HLA-B*15:01; and MMP-9 and SARS-CoV-2 similar peptides
with elevated affinity to HLA-B*39:01, are detected. Conclusions. This
is a proof of the concept study, which revealed potential involvement of
molecular mimicry in NETs-pathology within susceptible individuals, in
case of being infected with SARS-CoV-2.
Boundary layer stagnation point flow of nanofluid over a stretching sheet with nanoparticle electrification and viscous dissipation
Authors: Panda Subhashree , Misra Ashok , Mishra Saroj , Prakash Jagdish
Published: January 2024

The present paper investigates the effect of electrification and viscous
dissipation on boundary layer stagnation point flow of nanofluids
towards stretching sheet. For this purpose, a steady state flow of
water-Cu nanofluid has been considered. An efficient mathematical model
has been developed using Matlab to understand the variation of
non-dimensional velocity profile (f’(η)), non-dimensional temperature
profile (θ(η)) and dimensionless concentration distribution of
nanoparticle S(η). Using the similarity variables, the boundary layer
equations of flow field has been transferred to nonlinear ordinary
differential equation. The present model has been validated with
available literature and the results show good agreement. The effect of
five different parameters such as stretching parameter (ε), Brownian
motion (Nb), Thermophoresis (Nt), Ecket Number (Ec), Schmidt Number (Sc)
and Electrification (M) of nanoparticles on heat and mass transfer
characteristics of boundary layer stagnation point flow of the Cu-water
nanofluid towards stretching sheet has also been calculated. The
non-dimensional velocity profile shows an increasing trend with higher
values of ε, M, Nb, Nt.
Existence and stability behavior of fractional stochastic differential equation driven by Rosenblatt process
Authors: C. Mattuvarkuzhali , Balasubramaniam P.
Published: January 2024

This work focus on a nonlinear mathematical model deal with the
stability of visual trajectory track during locomotion in the fish robot
is developed. Previously the visual trajectory model has derived through
stochastic differential equation. The source of long memory, and more
precisely of infinite memory, is due to infinitely large time constants.
Thus, Fractional calculus theory is developed to get better model. (1)
The fractional stochastic differential equation (FSDEs) is utilized to
determine the parameters that ensure the coordination between the
unstable visual trajectory track and the stable visual trajectory track
of the fish robotic system and robot driver. (2) Existence and stability
results are derived through successive approximation and Bihari’s
inequality, semigroup theory, and fractional calculus in stochastic
settings. (3) Stability results of Rosenblatt process and numerical
simulation are established and applied for collision free track in the
visual trajectory track of the fish robot. (4) Stability of FSDEs
through Rosenblatt process entrusted depletion of collision in the ocean
water environment even in tiny particles from the visual trajectory to
the fish robot. There is no existing knowledge in this regard.
Therefore, the study is conducted. (5) The algorithms have several
advantages from gaze shift frame such as terrific quality of randomness,
key sensitivity, and collision free location stability. Numerical
simulation results manifest the effectiveness, efficiency and
feasibility of real-world applications.
Lifespan estimates for wave equations with damping and potential posed on asymptotically Euclidean manifolds
Authors: Liu Mengyun
Published: January 2024

In this work, we investigate the problem of finite time blow up as well
as the upper bound estimates of lifespan for solutions to
small-amplitude semilinear wave equations with time dependent damping
and potential, and mixed nonlinearities $c_1
|u_t|^p+c_2 |u|^q$, posed
on asymptotically Euclidean manifolds, which is related to both the
Strauss conjecture and the Glassey conjecture.
Incidence rate, long-term survival, and loss-of-life expectancy of children with acute lymphoblastic leukemia: a nation-wide analysis of Taiwan during 1997-2015
Authors: Tsai Chi-Wei , Lu Meng-Yao , Yu Alice Lin Tsing , Wang Jung-Der
Published: January 2024

Acute lymphoblastic leukemia (ALL) is the number one cancer in children
worldwide. Survival with ALL in children has shown a steady improvement
over time with contemporary chemotherapy. This study aimed to determine
the incidence rates and lifetime health impacts of pediatric ALL in
Taiwan. A total of 3,854 patients with the diagnosis of ALL (ICD-9-CM
code: 2040) were collected from the Registry for Catastrophic Illness
(RCI) between 1997 and 2015 to assure the diagnostic accuracy. We
included 2,044 cases for the final analysis. All patients were
followed-up until the end of 2017 by linkage with the National Mortality
Registry of Taiwan. A survival extrapolation method was applied and
validated to estimate the lifetime survival function for life expectancy
(LE) and loss-of-life expectancy (loss-of-life LE). The cohort included
1,222 males and 822 females. The average incidence rates (IRs) of
pediatric ALL from 1997 to 2015 for age strata of <1, 1-4,
5-9, 10-14, 15-18 were 1.24, 3.39, 2.21, 1.56, and 0.97 per 100,000
person-year, respectively. The cumulative incidence rate up to age 18
(CIR0-18) of pediatric ALL increased after 2001, and was more pronounced
in males than females. Most patients received treatments based on the
protocol of Taiwan pediatric oncology group (TPOG)-ALL-97 (23.0%) or
TPOG-ALL-2002 (62.7%). After extrapolation of survival to age 80, we
found LE and loss-of-LE of pediatric ALL were 54.5 and 15.2 years,
respectively. Future studies should explore long-term survival for
different groups at risk of pediatric ALL and impacts of ALL on the
society.
Extreme fetal macrosomia at 42 gestational weeks: a case report and literature review
Authors: Kummer Julia , Jebens Anja , Mihajlov Valentin , Pech Luisa Maria , Hellmeyer Lars
Published: January 2024

Excessive neonatal birth weight with its increasing figures complicates
obstetrical management as well as outcome severely and is associated
with gestational diabetes and maternal obesity. The increase in
pregnancies complicated by maternal obesity and gestational diabetes
emphasizes the necessity of evidence-based clinical interventions to
prevent or decelerate these diseases. If prenatal care is not frequented
by mothers-to-be there are no options open for obstetricians to detect
fetal macrosomia and to intervene.
Long-term changes in cesarean delivery and recurrence in Norwegian nulliparous women, 1967-2014: A population-based study
Authors: Sima Yeneabeba , Skjaerven Rolv , Kvalvik Liv , Morken Nils-Halvdan , Klungsoyr Kari , Sorbye Linn Marie
Published: January 2024

Objective: To describe long-term changes in Cesarean Delivery (CD) and
estimate CD recurrence risk across five decades. Design:
Population-based cohort study Setting: Norway, 1967-2014 Sample: A total
of 951,895 nulliparous women with their singleton, cephalic, term
deliveries were followed through their first and second births. Methods:
Data from the Medical Birth Registry of Norway was used to describe CD
by maternal age (years): <20 (reference), 20-24, 25-29, 30-34,
35-39 and >=40 and onset of labor: spontaneous (reference),
induced and pre-labor CD. Based on seven risk factors, women were
grouped as lower (no factors) - and higher-risk (one or more factors).
Risk estimates were stratified by periods: 1967-1982, 1983-1998 and
1999-2014. Multivariable regression models were used to estimate
relative risk (RR) with 95% confidence interval (CI). Results: CD in
the first birth increased across periods from 3.3% to 10.2% and from
8% to 20.5% in lower- and higher-risk women, respectively. The
increase in CD was only found among women < 35 years. Compared
to women with spontaneous onset, the RR of CD in lower-risk women with
induced onset of labor increased from 3.8 (95% CI 3.6-4.0) to 5.9 (95%
CI 5.7-6.2) across periods. Overall CD recurrence risk was 57.9%, but
relative recurrence risk was lower in the last than in the first period.
Conclusion: Overall CD risk increased over time in Norwegian women
<35 years both in lower- and higher- risk groups, while it was
stable or decreased in older women. CD recurrence risk declined across
47 years in Norway.
IMPACT OF COVID-19 PANDEMIC ON HOSPITALIZATION FOR INFLUENZA-RELATED PNEUMONIA: A CROSS-SECTIONAL STUDY
Authors: Gasbarrini Giovanni , Covino Marcello , Gasbarrini Antonio , Franceschi Francesco
Published: January 2024

Introduction. Since the introduction of first measures designed to tame
the COVID-19 pandemic, several speculations have been made about their
simultaneous effect on seasonal influenza. Although social distancing
policies could be effective in mitigating influenza spread, the ultimate
consequences remain unknown. Aim of this study is to evaluate the effect
of COVID-19 pandemic on influenza related-pneumonia in hospitalized
patients. Methods. We conducted a cross-sectional retrospective analysis
to evaluate the rate of influenza-related pneumonia in current pandemic
year (April 2020 to March 2021), compared to previous five years (April
2015 to March 2020). Analysis was based on the clinical records and
ICD-9 diagnosis code of all adult patients admitted for pneumonia at
Fondazione Policlinico Universitario A. Gemelli, IRCCS of Rome. The
diagnosis of pneumonia caused by influenza and by other common
respiratory tract viral infections were assessed. Results. Overall
15,029 (15.2%) hospitalized for pneumonia were considered. Patients’
median age was 76 years [interquartile range 64 – 84); males were
8652 (57.6%). Influenza-related pneumonia almost disappeared in the
2020-2021 (0.0002%) compared previous five years (1.5%). Conversely,
other virus related pneumonia had a similar incidence in both the
evaluated periods. Discussion The present analysis suggests that during
COVID-19 pandemic the cases influenza-related pneumonia was basically
absent among our hospitalized patients. Interestingly, other
virus-related pneumonia showed a countertrend, and the actual incidence
rate was slightly higher than previous five years. Further
investigations are needed to assess the ultimate effect of COVID-19
pandemic on the total trend of influenza and other respiratory tract
infections.
A Very Efficient Method of DNA Extraction from Bone Powder
Authors: Niaz Mubeen Ali
Published: January 2024

When a person die human body decomposes after some time. Although body
is decomposed but we can still extract DNA from remains like bone and
teeth. Bone is the best source of DNA. It helps in forensic science as
we know when somewhere disaster happens or a person killed by some other
activities like bomb blast. The only source to identify the person is
DNA. Now the question is how to extract DNA. That’s what we will
understand in very simple way that how can we extract DNA from Bone. For
this purpose, we took bone remains from a graveyard in Multan city.
UTILITY OF REFLUX FINDING SCORE AND REFLUX SYMPTOM INDEX IN DIAGNOSIS OF LARYNGOPHARYNGEAL REFLUX DISEASE
Authors: Abraham Zephania , Kahinga Aveline
Published: January 2024

Objective: The study aimed to determine the utility of reflux finding
score (RFS) and reflux symptom index (RSI) in diagnosis of
laryngopharyngeal reflux disease (LPRD) in Dar es Salaam, Tanzania
Design: Hospital based descriptive cross sectional study. Participants:
Patients with throat and voice complaints for more than a month provided
they have no other underlying cause such as tumors of the aerodigestive
system or chronic irritants of the larynx such as cigarette smoking or
those with misuse of voice such as choir singers, teachers. Main outcome
measures: Statistical analyses described the utility of RFS and RSI in
diagnosis of LPRD as designed by Belafsky et al where the diagnosis of
reflux was made when the patient had an aggregate RSI score
>13. Results: In this study, a total of 2500 patients were
recruited, out of which 800 (32.0%) were males and 1700 (68.0%) were
female. Out of the 2500, 1520 (60.8%) patients were found to have a RSI
of >13. Out of the 1520 patients subjected to 70-degree
laryngoscopy, 1425 patients (95.0%) were found to have a RFS
>7. Of the 1425 patients with RFS >7, 260 were
males (18.2%) and 1165 were females (81.8%). Conclusion: RFS and RSI
have shown utility in diagnosing LPRD and they remain to be applicable
even in resource-limited settings. There should be universal treatment
protocol for LPRD since it vary among countries and health systems
Consideraciones ocasionales. Artículos, ensayos y conferencias
Authors: Camacho Oviedo Nayib
Published: January 2024

Damos la bienvenida y le auguramos una cualificada recepción en el ámbito universitario y cultural en general, a la significativa y reciente obra del profesor Nayib Camacho O., Consideraciones ocasionales. Este nuevo trabajo, que hemos tenido el privilegio de leer, se destaca por su atinado enfoque crítico y por su sensibilidad para abordar y plantear cuestiones decisivas de nuestro diario vivir, deliberar y pensar en el campus y en el diverso y complejo universo de la cultura, las artes, la ciencia y la tecnología. Es un libro polivalente y necesario, que se debe leer entre líneas, pues constituye un registro audaz y en esa medida auténtico, para romper nuestro conformismo y pasividad en relación con los puntos álgidos que ocupan nuestras preocupaciones cotidianas. En la medida en que el libro los tematiza, los torna sugestivos a la reflexión y el análisis. Miguel Antonio Guerrero Borda
Percepción de la violencia de género en el alumnado de las instituciones de educación superior. Caso: FAD-UAEMéx
Authors: Villar García María-Gabriela , Jauregui Caballero Ariadna
Published: January 2024

Estudiar las condiciones desde las cuales se establecen relaciones de género en instituciones de educación superior (IES), en particular las de orden público, se ha convertido en una necesidad que tiene como fin analizar las formas de convivencia en estas comunidades. Esto se debe a que las relaciones sociales ya establecidas se replican y son réplica de una red social que va más allá del espacio académico. Al abordar la perspectiva de género (PEG), se puede coadyuvar para promover una reflexión sobre las pautas de conducta deseadas para la convivencia en grupos. Se entiende a la PEG como una estrategia que es resultado de procesos de socialización que buscan la equidad y la igualdad como valores compartidos. Por ende, el objetivo de este artículo es presentar un análisis descriptivo sobre la percepción del alumnado de la Facultad de Arquitectura y Diseño (FAD) de la Universidad Autónoma del Estado de México (UAEMéx) sobre la violencia de género en las relaciones interpersonales como acto de discriminación. El propósito es destacar elementos que propician su ejercicio y reconocer criterios para establecer estrategias que permitan prevenir los fenómenos mencionados. Metodológicamente, se muestran resultados de diagnósticos de investigaciones in situ, que exponen a los actores y ambientes que participan en las prácticas comúnmente categorizadas dentro de la violencia y discriminación. Asimismo, se exhibe cómo desde un abordaje metodológico de orden cuantitativo es posible generar datos sobre la percepción de la discriminación y violencia en el contexto, lo cual permitirá establecer estrategias con PEG que prevengan la naturalización de esta violencia.
Kinerja Usahatani Perkebunan Kakao Monokultur dan Polikultur di Kecamatan Gedong Tataan Kabupaten Pesawaran Provinsi Lampung
Authors: Sari Dewi Mulia , Zakaria Wan Abbas , Indah Lidya Sari Mas , Saleh Yuliana , Seta Amanda Putra
Published: January 2024

Cocoa is one of the leading plantation commodities in Lampung Province.  This commodity has contributed high export value in raw form and has become the main raw material in various agro-industries.  The main cocoa production center in Lampung Province is Pesawaran. All cocoa plantations in Pesawaran Regency are smallholder plantations.  Smallholder plantations have an important and strategic role, especially in increasing income and providing employment for the community.  There are two research objectives.  First, to analyze the performance level of monoculture and polyculture cocoa plantations in Gedong Tataan Sub-district, Pesawaran Regency, Lampung Province.  Secondly, to analyze the difference on the profit levels of cocoa plantations with monoculture and polyculture in Gedong Tataan Subdistrict, Pesawaran Regency, Lampung Province.  The research location was selected purposively by the consideration that Sungai Langka Village is the main cocoa bean producer in Gedong Tataan Subdistrict, Pesawaran Regency. The research was conducted by a survey method, in which samples of 34 cocoa farmers were chosen by simple random sampling technique. The results showed that R/C ratio on total costs obtained by cocoa farmers with monoculture cropping pattern is 2.97. Meanwhile, the highest level of R/C ratio on total costs of polyculture is the cocoa-coffee-durian cropping pattern (3.69).  There was no significant difference between performance of monoculture and on polyculture cocoa plantations. Key words: cocoa, monoculture, polyculture, performance
PERSEPSI KONSUMEN TERHADAP BAURAN PEMASARAN DAN PENGAMBILAN KEPUTUSAN PEMBELIAN RUJAK BUAH ULEK DI ISTANA RUJAK BENGKULU
Authors: Aryani Desi , Arianti Nyayu Neti , Priyono Basuki Sigit
Published: January 2024

This study aims to analyze consumers’ perceptions of the marketing mix and purchasing decision of ground fruit salad (rujak buah ulek) at the Istana Rujak.  Respondents in this study are 96 people, namely those who had bought and consumed rujak buah ulek of the Istana Rujak at least twice. Respondents were taken accidentally. Consumers’ perceptions and purchasing decision process were analyzed descriptive qualitatively.   The results showed that consumers’ perceptions on all marketing mix components, namely product, price, promotion, and place at Istana Rujak, were in good category. Most rujak buah ulek Istana Buah consumers stated that they needed to carry out all stages of the purchasing decision process, namely recognition need, information search, evaluation of alternatives, purchase decision, and post-purchase evaluation.Key words: marketing mix, purchasing decision, rujak buah ulek
ANALISIS HARGA POKOK PENJUALAN DAN KEUNTUNGAN AGROINDUSTRI SIRUP JERUK KASTURI (STUDI KASUS PADA AGROINDUSTRI RATU KASTURI KOTA MEDAN)
Authors: Silalahi Patresia Eirene S.A , Haryono Dwi , Indriani Yaktiworo
Published: January 2024

The main objective of this study is to examine the cost of goods sold and profits of Ratu Kasturi’s Kasturi Orange Syrup Agroindustry. The resource persons in this study are agro-industry owners, personnel of the agro-industry, and field workers at the Department of Industry and Trade of the City of Medan. Data collection was carried out in November - December 2022. Data were analyzed using descriptive quantitative analyses (cost of goods produced, cost of goods sold, and profit analysis). The method used in this research is a case study in Ratu Kasturi’s Kasturi Orange Syrup Agroindustry in Medan City. The findings of the present study showed that the cost of produced goods was IDR34,272.82/bottle and the cost of sold goods was IDR35,272.82/bottle. The selling price of Kasturi orange syrup is IDR65,000.00/bottle with a profit margin of 84.28 percent. The total profit from the sale of Kasturi orange syrup in November 2022 was IDR22,991,512.50, so this business is considered profitable.  Key words: cost of goods sold, cost of goods manufactured, profits
VALUASI EKONOMI DAN PERSEPSI WISATAWAN TERHADAP WISATA PANTAI M BEACH DI KABUPATEN LAMPUNG SELATAN PROVINSI LAMPUNG
Authors: Saputra Muhamad Riyan , Rosanti Novi , Murniati Ktut
Published: January 2024

This research aimed to analyze the tourist travel costs, the factors that influence the frequency of tourist visits, the economic value of tourism, and the tourists' perceptions of M Beach. This research used a survey with a sample of 50 tourists from M Beach was selected using the accidental sampling method. The travel cost method is used to analyze the economic value, and the descriptive method with a Likert scale measuring instrument is used to analyze tourist perceptions. The determination of location was carried out purposively with the consideration that M Beach has been the best-selling tourist attraction in South Lampung Regency for the last five years. The data was collected in January 2023. The results showed the average travel costs incurred by M Beach tourists were Rp146.265,24 per individual per visit, with the highest allocation of travel costs viz consumption costs of 38,43 percent. The factors that influence tourists visits to M Beach are travel costs, distance, income, age, beach conditions, and public facilities. The total economic value of M Beach tourism is Rp10.474.348.786,00 per year. Tourists perception of M Beach in terms of 4A components (attraction, amenity, accessibility, and ancillary) has a positive perception with good criteria.Keywords: Economic value, M Beach, Perception, Travel cost
Hope beyond Hope
Authors: Kallio Galina
Published: January 2024

Hope for a better future has become a survival strategy within contemporary Western societies that are drifting through polycrises. The concept of hope evokes future orientedness, suggests positive emotions and creates spaces for dreaming. But what if, instead of hope, it is hopelessness that moves people to strive for living a better life and leads to, in the words of Macy and Johnstone, the great turning? In this article, I draw on my ethnographic fieldwork to bring forth journeys of regeneratively oriented farmers who (have started to) build a radically different life by pursuing livelihoods through diversified small-scale farming. By analysing how hope is manifested in the work and everyday lives of the farmers, I introduce an understanding of hope as action and show how hope in the context of the studied farming practices materialized through cultivating the lands, inspiring others, and reciprocating the hope of other species. I argue that conceptualizing hope as action suggests a different kind of temporality, one that is (literally) grounded in intergenerational farming landscapes: hope as action brings into play both the hope(s) and the hopelessness(es) of the past that impacts the actions of the present and of the future that orients the actions of today. As farmers and (their) soils are being rapidly mobilized into vessels of hope for their potential to sequester atmospheric carbon, understanding the kind of action hope invokes (or doesn’t) is important to better understand whose hopes are being mobilized through regenerative agriculture and how and why these hopes are mobilized.