bluuebunny/crossref_metadata_2025 huggingface dataset:
Caracterização dos lactentes com microcefalia
Authors: Araújo Lucas de Oliveira , Santos Josely Bruce dos , Felzemburgh Ridalva Dias Martins , Jesus Carla Cristina Oliveira de , Almeida Aglaya Oliveira Lima Cordeiro , Pereira Lívia Pinheiro
Published: December 2018

Objetivo: Caracterizar os lactentes com microcefalia quanto às variáveis demográficas e de saúde. Métodos: Estudo quantitativo, descritivo, desenvolvido em um hospital, em Salvador-Bahia, Brasil, com objetivo de descrever as características demográficas de mães e de saúde de 72 lactentes com diagnóstico de microcefalia, utilizou-se um formulário com questões fechadas e estruturadas, a análise foi realizada através de estatística descritiva, os dados foram organizados e analisados utilizando-se o programa (SPSS) versão 12.0. Resultados: 83,4% tinham posto de saúde no bairro; 98,6% realizaram Pré-natal, 72,2% transporte público, 81,9% coleta de lixo, 81,6% rede de esgoto, 72,2% pavimentação asfáltica, 91,7% iluminação pública, 90,3% focos de mosquito na residência; 66,7% sem malformação congênita, 95,9% alterações na fontanela, 86,1% Hipotonia Axial, 80,6% Hipertonia sem estimulação e 76,4% com estimulação, 90,3% Hiperreflexia, 94,4% apresentaram apatia, 94,4% irritabilidade, 86,1% tremores, 69,4% com caderneta de vacina atualizada, 94,4% procuraram emergência, 90,3% sem acompanhamento ambulatorial. Conclusão: Estes dados poderão contribuir para diminuir as lacunas existentes no que se refere à microcefalia no Brasil e desta forma possibilitar a tomada de ações que visem à identificação precoce de possíveis riscos permitindo desta forma o enfrentamento adequado nos mesmos.
Enfermagem e a Diversidade Transcultural Amazônica: Um Relato de Experiência
Authors: Silva Ana Gracinda Ignácio da , Sardinha Daniele Melo , Costa Hugo de Paulo Garcia da , Teixeira Jessica de Lira , Pereira Jessica de Souza , Silva Karina Borges da , Avíz Luciana Emanuelle , Carvalho Milene do Socorro Bastos de
Published: December 2018

Objetivo: Identificar as diversas formas de saberes e fazeres populares como uma questão que precisa ser conhecida e discutida na comunidade acadêmica, e como uma teoria de enfermagem pode embasar a atuação do enfermeiro de forma transcultural. Relato de Experiência: Foi realizado uma pesquisa bibliográfica sobre o tema e a partir do conteúdo apreendido foi elaborado uma cartilha educativa contendo as práticas e cuidados saúde/doença dos povos indígenas, ribeirinhos e afrodescendentes sob a ótica da teoria transcultural. Em seguida foi apresentado aos acadêmicos de enfermagem do 7º. Período da Faculdade Metropolitana da Amazônia (FAMAZ).  Discussão: O estudo mostrou uma teoria de enfermagem que permite tratar com respeito crenças, rituais diferentes dos nossos e que isso se constitui em ter um olhar holístico sobre pessoas que fazem parte de várias etnias e praticam um modo de cuidado tradicional, assim como, a diversidade cultural e étnica da Amazônia, suas práticas de cuidados com a saúde possibilitando construir uma tecnologia leve para difundir esse conhecimento na faculdade. Considerações Finais: A cultura amazônica é formada por diversos povos, os mesmos possuem conhecimentos próprios e os profissionais de saúde devem conhecer e saber como lidar e respeitar suas experiências integrando-as ao cuidado científico. A elaboração da cartilha com essas informações proporcionou difundir esse conhecimento a outros acadêmicos de enfermagem, com a certeza que cuidar nessa perspectiva é um grande desafio para os enfermeiros.
Seafood supply assessment in the 21st Supply Deposit of Brazilian Army
Authors: Martins Werner Souza , Leite Ana Beatriz de Campos , Martins Raquel Luciano , Silva Jader Oliveira da , Balian Simone de Carvalho
Published: December 2018

Objectives: The aim of present study was to evaluate the sanitary characteristics associated to the Quality and Identity Standards of the frozen seafood provided for the 2nd MR by 21st SD; Identify strengths, weaknesses, opportunities and threats to optimize the supply process; Propose a strategic approach to mitigate supply non-compliances. Methods: Were performed seven Focus Groups, a SWOT analysis and the swot factors were weighted with the application of the Analytical Hierarchy Process AHP. Results: The frozen seafood supply process of the 2nd MR, centralized in the 21st SD, needs a technical, operational and documental restructuration, to ensure the maximum efficiency in the seafood purchase, storage and distribution; It is very important the participation of specialized Officers in the bind writing process. Conclusion:  It is recommended the implementation of FSMS and qualify the staff. The adoption of strategies with focus in the Food Security is necessary to ensure a good and safety nutrition and reaching the results can promote the development of social changes through qualifing officers and soldiers.
Electronic Structure Benchmark Calculations of Inorganic and Biochemical Carboxylation Reactions
Authors: Douglas-Gallardo Oscar A. , Sáez David A. , Vogt-Geisse Stefan , Vöhringer-Martinez Esteban
Published: December 2018

Carboxylation reactions represent a very special class of chemical reactions that is characterized by the presence of a carbon dioxide (CO2) molecule as reactive species within its global chemical equation. These reactions work as fundamental gear to accomplish the CO2 fixation and thus to build up more complex molecules through different technological and biochemical processes. In this context, a correct description of the CO2 electronic structure turns out to be crucial to study the chemical and electronic properties associated with this kind of reactions. Here, a sys- tematic study of CO2 electronic structure and its contribution to different carboxylation reaction electronic energies has been carried out by means of several high-level ab-initio post-Hartree Fock (post-HF) and Density Functional Theory (DFT) calculations for a set of biochemistry and inorganic systems. We have found that for a correct description of the CO2 electronic correlation energy it is necessary to include post-CCSD(T) contributions (beyond the gold standard). These high-order excitations are required to properly describe the interactions of the four π-electrons as- sociated with the two degenerated π-molecular orbitals of the CO2 molecule. Likewise, our results show that in some reactions it is possible to obtain accurate reaction electronic energy values with computationally less demanding methods when the error in the electronic correlation energy com- pensates between reactants and products. Furthermore, the provided post-HF reference values allowed to validate different DFT exchange-correlation functionals combined with different basis sets for chemical reactions that are relevant in biochemical CO2 fixing enzymes.
A Brief Pedestrian Derivation of E = mc2 for the Amateur Enthusiasts
Authors: Elani Zion
Published: December 2018

This note presents a pedestrian derivation of E=mc2 for freshmen in chemistry, with a method similar to that of `handling units'. Such a picturesque derivation of the formula uses nothing but Newtonian laws of motions that do not go beyond mere definitions, together with well-known elementary physical quantities such as distance, velocity, force, momentum, and energy. The pedagogic merit of such an approach is discussed.The following notes are stimulated from class lectures given to students in college preparing for a major in chemistry and to freshman in chemistry. While they constitute no original contribution to a subject that has been widely discussed, it is hoped that they may be of help to some teachers, students, and any enthusiast amateurs.
Electronic or steric effects: Detailed DFT investigations of titanium amino based Kaminsky type olefin catalysts
Authors: Saßmannshausen Jörg
Published: December 2018

We report detailed Density Functional Theory (DFT) investigations of a series of structurally similar titanium (IV) chelating σ-aryl catalysts. Particular attention was paid to the electronic charges of the Ti, C ipso of the substituted aryl group and the benzylic CH2 and Cipso atoms. The Bader and NBO derived charges were compared with the recently reported polymerisation results by Chan. We found a strong correlation between the relative energies of one of the computed isomers and the activity of the catalyst. Neither NBO nor Bader charges could be convincingly correlated to the observed activity.
Good Questions 5. How can a food product be both old and new?
Authors: Kent George
Published: December 2018

How can some foods and food additives be regarded as novel and subject to patent claims and at the same time be obviously safe? In dealing with its responsibilities to ensure the safety of foods it looks like the U.S. Food and Drug Administration (FDA) acts in ways that favor the manufacturers and expose consumers to unnecessary risk.

The FDA uses the term GRAS, Generally Regarded as Safe, to identify products as not requiring further study to establish their safety. Any person may “notify” FDA that a product is GRAS. The FDA does not accept or agree with the notifier’s GRAS conclusion. Usually the FDA simply does not question the notifier’s claim.

This peculiar approach to “regulation” by the FDA is illustrated here through examination of Evolve BioSystems’ new trademarked product, Evivo, claimed to be “the first and only probiotic powder clinically proven to restore the infant gut microbiome to its original, natural state.”

Evivo is obviously a new and unfamiliar product. It is only because it is novel that Evolve Biosystems pursued patents relating to it. The FDA’s primary responsibility is to protect public health. The FDA’s refusing to accept a GRAS claim by a manufacturer would not be an assertion that it the product is unsafe. It would simply be an assertion that, as a matter of prudence, the safety of this product should be investigated by an objective agency both before and after it is marketed. That is not too much to ask, especially when the consumers are to be highly vulnerable children.
The Agrarian Crisis and Its Nutritional Consequences in India
Authors: Ittyerah Anil Chandy , Holla Radha
Published: December 2018

India is currently in the grip of an unprecedented agricultural crisis, which has led to the suicide of over 300,000 farmers over the past two and half decades. The crisis has been caused by multiple factors including lack of a sustainable agricultural policy, globalization, and decreased state investment in agriculture concurrent with an increased role of private players and climate change. This has led to reduced income for farmers and increased farmers’ indebtedness, which in turn affects the nutritional status of farming families, particularly women and children. In 2017, India was ranked 100 out of a total of 117 countries by the Global Hunger Index. The focus of state schemes related to nutrition has been on ensuring food security rather than nutrition security.

The agrarian crisis is increasingly making agriculture an unviable occupation and hundreds and thousands of farmers are opting out of working on the land to move to urban areas, where jobs are scarce, further deepening the nutritional crisis. The long-term sustainable solutions include sustainable use of resources of land, seed, and water through promotion of low-input agriculture that is tailored to the nutritional and income needs of farmers and their families, and to the agro-ecological conditions of the region. Agricultural policy must enable the small and marginal farmer to earn a fair income and to be free of debt by ensuring access to procuring agencies, an adequate price for produce, and low-interest micro-loans.
Statistical Disclosure Limitation: New Directions and Challenges
Authors: Shlomo Natalie
Published: December 2018

An overview of traditional types of data dissemination at statistical agencies is provided including definitions of disclosure risks, the quantification of disclosure risk and data utility and common statistical disclosure limitation (SDL) methods. However, with technological advancements and the increasing push by governments for openand accessible data, new forms of data dissemination are currently being explored. We focus on web-based applications such as flexible table builders and remote analysis servers, synthetic data and remote access. Many of these applications introduce new challenges for statistical agencies as they are gradually relinquishing some of their control on what data is released. There is now more recognition of the need for perturbative methods to protect the confidentiality of data subjects. These new forms of data dissemination are changing the landscape of how disclosure risks are conceptualized and the types of SDL methods that need to be applied to protect thedata. In particular, inferential disclosure is the main disclosure risk of concern and encompasses the traditional types of disclosure risks based on identity and attribute disclosures. These challenges have led to statisticians exploring the computer science definition of differential privacy and privacy- by-design applications. We explore how differential privacy can be a useful addition to the current SDL framework within statistical agencies.
Relaunching the Journal of Privacy and Confidentiality
Authors: Vilhuber Lars
Published: December 2018

This issue is the first to appear after a longer intermission. We have replatformed the journal, but we continue the original mission of publishing innovative materials from many disciplines in the areas of privacy, confidentiality, and disclosure limitation.
Memories of Steve Fienberg
Authors: Steorts Rebecca Carter
Published: December 2018

In 2015, Steve and I traveled together to Ithaca from Pittsburgh for a workshop on differential privacy (DP). This is one of my fondest memories with Steve for many reasons. The trip involved many of my favorite things, which Steve and I both shared --- statistics, hockey, great food, and good conversation. For me, this is one of my most memorable trips with Steve, as I learned so much from our conversations together.
(Re)imagining a course in language and intercultural communication for the 21st century
Authors: Diaz Adriana Raquel , Moore Paul J.
Published: December 2018

Over twenty-five years ago, leading scholars in the field of intercultural communication William B. Gudykunst, Stella Ting-Toomey and Richard Wiseman published the paper “Taming the beast: Designing a course in intercultural communication.” We revisit their work in light of renewed interest in the design and implementation of the intercultural communication (ICC) course as a key site for engaging with diversity in universities around the world. Our paper draws on Gudykunst et al.’s overview of four major issues instructors should consider in designing and delivering an introductory ICC course: (a) philosophical and ethical issues, (b) pedagogical issues, (c) curricular content; and (d) resources and teaching techniques. We draw on these four issues to conduct a critical appraisal of the current state of the ICC field and to reflect on Gudykunst et al.’s recommendations in the 21st century. We pay particular attention to the increasingly stronger links between the fields of ICC and modern/foreign language (MFL) education through the key role that language(s) play in meaning making in interaction. We therefore use the issues identified by Gudykunst et al.’s seminal work as a springboard to discuss key parameters that may assist instructors in the design of a reimagined ICC course, responsive to the crucial role of language and languages in engaging with diversity.
Prediksi Curah Hujan Bulanan Di Kota Samarinda Menggunakan Persamaan Regresi Dengan Prediktor Data Suhu dan Kelembapan Udara
Authors: Putramulyo Satriyogi , Alaa Siti
Published: December 2018

Prediksi curah hujan bulanan dengan menggunakan prediktor suhu udara dan kelembapan udara telah dilakukan. Data diperoleh dari Stasiun Meteorologi Temindung Samarinda. Evaluasi dilakukan dengan membandingkan dan menghitung besarnya penyimpangan prediksi curah hujan bulanan terhadap hujan hasil observasi. Data yang digunakan adalah data harian yang dijumlahkan dan diratakan pada setiap bulannya. Untuk menganalisa digunakan data dari tahun 2005 sampai 2015 sedangkan data tahun 2016 untuk membandingkan hasil prediksi terhadap observasi. Prediksi curah hujan bulanan menggunakan metode regresi linier berganda. Hasil pengolahan data menunjukkan bahwa secara umum prediksi curah hujan bulanan tahun 2016 di kota Samarinda mengalami under estimate (lebih kecil dari nilai aktualnya) dan hasil prediksi yang paling baik terjadi pada bulan Oktober. Prediksi curah hujan bulanan dengan prediktor suhu dan kelembapan udara menghasilkan nilai koefisien korelasi sangat kuat dan RMSE yang baik yaitu r = 0.93 dan RMSE = 46,26%.
Transrectal biopsy under ultrasound guidance using shear wave elastography in men with suspected prostate cancer
Authors: Ф. З. Гайсенюк  , С. В. Головко  , Б. В. Джуран  , В. В. Когут  , А. І. Сагалевич  , О. Ф. Савицький  , В. М. Кравчук
Published: December 2018

Prostate cancer is the second malignant tumor by prevalence among men. Question of timely diagnosis of this disease is extremely important. Despite the large number of screening tests, the development of new visualization techniques and the use of invasive procedures such as biopsy, prostate cancer remain difficult for early diagnosis. The main disadvantage of a standard multifocal biopsy of the prostate is lack of specificity of ultrasound beam in B-mode. Particularly, the tumor node is isoechogenic in 30% cases.The objective: проаналізувати застосування еластографії зсувної хвилі як додаткового методу отримання зображень ПЗ.Materials and methods. The study included 31 patients. Patients were divided into 4 groups: the first group – control (conditionally healthy) (n=7), the second group – patients with benign prostatic hyperplasia (n=8). The third group – patients with chronic prostatitis (n=8). The fourth group – patients with prostate cancer (n=8). All patients performed a complex transrectal ultrasound (TRUSD), endocavital EC 6.5 MHz/10R sensor using shear wave elastography. Patients in the 2,3,4 group performed a transrectal, multifocal biopsy of the prostate gland. The biopsy was performed on a standard 12-point circuit. Additionally, a biopsy was performed from suspicious sites detected by the shear wave elastography.Results. In all patients, the pathological findings are correlated with the data of the shear wave elastography.Conclusion. The shear wave elastography should be an additional method of obtaining images of the prostate, complementary to traditional transrectal ultrasound and MRI.
Premature ejaculation: a modern view at the problem
Authors: Г. С. Кочарян
Published: December 2018

Data are submitted on the frequency of premature ejaculation and its definitions in the International Classification of Diseases of the 10th Revision, the Diagnostic and Statistical Manual of Mental Disorders of the 4th and 5th Revisions (USA), and in the recommendations of the special committee of the International Society for Sexual Medicine. The biological and the biopsychosocial approach to assessing the duration of sexual intercourse are presented and characterized. It is concluded that the biological approach to its evaluation which is fully applicable to animals is insufficient for humans, since it does not take into account the extremely important recreational aspect of intimate intimacy in people. Psychogenic and biogenic factors involved in the formation of premature ejaculation are presented. It is concluded that attempts to completely eliminate or significantly downplay the role of biogenic factors in the genesis of this dysfunction should be considered untenable.
Zinc and Copper in antioxidant defense system in patients with chronic nonbacterial prostatitis
Authors: В. І. Тріщ
Published: December 2018

Among men of working age chronic prostatitis is the most frequent urological sickness, and characteristic symptoms of it are frequent reason of the urological recourse. Therefore this excuses a search for new methods of examination and treatment of the patients with this pathology.The objective: purpose of our research was studying of level of Zinc and Copper in blood and ejaculate and specialty of antioxidic defense of the patients with chronic nonbacterial prostatitis.Materials and methods. Under supervision were 120 patients with chronic nonbacterial prostatitis, among them 60 patients with inflammatory chronic pelvic pain syndrome(category IIIA) and 60 patients with noninflammatory chronic pelvic pain syndrome (category IIIB). Microelements Zinc and Copper in whole blood an ejaculate were determined using atomic absorption spectrophotometry on C-115 PC. State of antioxidant defense was judged considering quantification of Catalase after A. Bach and S. Zubkova and Superoxide Dismutase.Results. A certain decrease of Zinc and increase of Copper were observed in both groups of patients with chronic nonbacterial prostatitis. More expressed decrease of Zinc and increase of Copper were observed in patients with inflammatory chronic pelvic pain syndrome. Also it was noted that with long duration of chronic nonbacterial prostatitis takes place the antioxidant enzymes level decrease. More expressed decrease was observed in patients with inflammatory chronic pelvic pain syndrome. As a result of correlation analysis it was found that there is certain dependence between level of Zinc, Copper in blood and antioxidant defense enzymes.Conclusion. With chronic nonbacterial prostatitis were observed decrease of Zinc and increase of Copper levels in blood as well as in ejaculate of the patients. More intense decrease of Zinc and increase of Copper were noted in patients with inflammatory chronic pelvic pain syndrome. Metabolic changes with shortage of Zinc and excess of Copper correlate with antioxidant system disbalance, that is with antioxidant defense level decrease.
Research of the level of the C-reactive protein in patients with chronic bacterial prostatitis and it’s diagnostical value
Authors: Є. А. Литвинець  , А. Кабіру
Published: December 2018

The objective: evaluation of diagnostical and prognostical value of determination of C-reactive protein in blood and ejaculate of patients with chronic bacterial prostatitis (CBP) and possibility of usage of this test for monitoring of the course of the disease.Matherials and methods. We examined 65 patients with chronic bacterial prostatitis aged from 20 to 50 years (main group) and control group, which was formed by 25 healthy men of the same age with ill patients.Results. In blood serum of patients with chronic bacterial prostatitis when referring the level of C-reactive protein was increased, almost in all patients it reached “highinflamative” range and made up in average 14,82±3,28 mg/l. Simultaneous determination of C-reactive protein in ejaculate of patients with CBP in stage of exacerbation had found concentration of biomarker, which exceeded blood indexes in 4,3 times and were on average 64,32±4,46 mg/l.Conclusion. In patients with chronic bacterial prostatitis in stage of exacerbation was determined significant increase of C-reactive protein in ejaculate, which in a few times exceeded it’s content in blood serum, which allowed to assume possibility of local synthesis of biomarker in involvement of prostate gland.
Calcium-oxalate nephrolithiasis and the bases of its metaphylaxis
Authors: Д. В. Черненко  , В. В. Черненко  , Н. І. Желтовська  , В. Й. Савчук
Published: December 2018

Hypercalciuria is the main lithogenic pathometabolism in calcium nephrolithiasis which manifests with multilateral impairments of metabolic risk factors of recurrent development of kidney stone disease and different types of hypercalciuria.Causes of hypercalciuria can include impairments of gastrointestinal function, hormonal impairments and their imbalance in the regulation of bone tissue metabolism, impairments of vitamin D metabolism, congenital genetic pathologies and dietary factors.There are distinguished 6 main types of hypercalciuria and different conditions, giving rise to hypercalciuria (oncology diseases and others).For performing metaphylaxis of calcium oxalic nephrolithiasis, it is necessary to differentiate types of calcium oxalic nephrolithiasis and choice of adequate treatment. Our study pays attention to absorbent calcium oxalic nephrolithiasis of types I, II, III and IV, renal, resorptive HK and tubular acidosis. There are also presented schemes of metaphylaxis and results of 3-year metaphylaxis of calcium oxalic nephrolithiasis.
Optimization of treatment idiopathic overactive bladder without detrusor overactivity
Authors: Ю. М. Дехтяр  , Ф. І. Костєв  , К. А. Залива
Published: December 2018

The objective: was to evaluate the effectiveness of monotherapy with competitive antagonist M-cholinoreceptors with tolterine tartrate and its purpose in combination with cyclic structural analogue of g-aminobutyric acid gabapentin in patients with idiopathic hyperactive bladder (IGAMP) without detrusor hyperactivity (DG).Materials and methods. The study involved 63 patients with IGAMP with urodynamically proven absence of DG (14 men and 49 women). Patients were divided into two groups: group A – 31 patients and group B – 32 patients. According to the design of the study patients of group A were prescribed therapy as a competitive antagonist of M-cholinergic receptors, which are localized in MP, – tolterodine tartrate. Group B patients used combination therapy with tolterodine tartrate and a medicinal form from the group of anticonvulsants – gabapentin. This choice of drugs is determined by the desire to effect a double effect on the lower urinary tract: eliminate both the sensory and the reflex component of the pathogenesis of urgent urination.Results. Analysis of the results of the use of anticholinergic monotherapy in group A made it possible to ascertain that, in general, this type of treatment does not lead to a significant improvement in the symptoms of urgent, frequent urination in patients with IGAMP without DG. But among the patients of group B, by the end of the 8th week of therapy there were 12 (37.50%) patients who achieved a 50% or greater reduction in the incidence of IGAMP symptoms.Conclusions. It was found that monotherapy in these patients is of low efficacy and is realized mainly due to a decrease in the frequency of urination per day (by 37.55%) and the frequency of incontinence episodes (by 52.14%), and to a lesser extent due to a decrease in the intensity of urgency (by 14.8%). Combination therapy allows for more effective elimination of the main objective and subjective symptoms of the disease, which manifests in a decrease in the frequency of pollakiuria by 64.17%, nocturia by 82.18%, urgency at 81.40% and urinary incontinence by 80.66%.
Reconstructive interventions in patients with gangrenous Fournier
Authors: О. Б. Прийма
Published: December 2018

The paper presents the results of a personal experience of performing reconstructive scrotum in 11 patients with Fournie gangrene. One patient observed an independent recovery of the scrotum within three months. Other patient refused to reconstructive intervention. In the remaining 10 patients, the reconstruction of the scrotum and the penis skin was performed by various methods. Applied a free autodermoplastic, a method of opposing triangular skin flaps, the formation of a scrotum from the rest of the original tissues, as well as the skin flap of the thigh on the leg. A good functional and cosmetic result has been obtained in all patients.
Needs of information and service for the male reproductive health in Zaporozhye region
Authors: О. А. Нікіфоров  , Г. В. Бачурин  , К. М. Єременко
Published: December 2018

Ukrainian men have problems with reproductive health more often than women in some situations. According to data from the WHO, “men’s factor” reaches 54% in infertility couple. Social research was conducted in the Zaporizhya region among 382 men and 243 women of reproductive age, the purpose was to study citizens’ awareness of the components of male reproductive health, the conditions of its preservation and the information needs on these issues. There is significant unsatisfied information demand on various components of men’s health preservation in many regions in Ukrainian’s society. There are significant limitations on the services of diagnosis and treatment of men’s reproductive function. The main direction of the new informational materials needs to become attraction of attention to the problem preserving individual male reproductive health, more responsible attitude to the self and marriage.
Clinical value detection of testicular microlithiasis and recently discovered markers in testicular germ–cell tumors
Authors: А. В. Сакало
Published: December 2018

Testicular germ-cell tumors (TGCTs) are the most frequent malignant tumors in men 20–40 years of age and the most frequent cause of death in this age group. TGCTs consist of two major groups: seminomas and nonseminomatous germcell tumors (NSGCTs). NSGCTs can be further divided into embryonic carcinoma, teratoma, yolk sac tumor, and choriocarcinoma, which differ in therapy, prognosis, but all show characteristics of the primordial germ cells. New biomarkers potentially represent novel molecular targets for treatment. The role of microRNA is highlighted as molecular prognostic factor in TGCT. Testicular microlithiasis (TM) often detected during examination among men with TGCTs, cryptorchidism, infertility, testicular atrophy and dysgenesis. Patients with TM form a group of risk of development of TGCTs. Also at high risk are patients with infertility, bilateral TM, atrophic and undescended testes and history of TGCTs.
The role of herpetic infection in the development of chronic abacterial prostatitis
Authors: Є. А. Литвинець  , А. І. Федорів
Published: December 2018

The objective: сonfirmation of herpes infection as an etiological factor of chronic abacterial prostatitis and creation of an algorithm for examining patients with chronic abacterial prostatitis of viral etiology.Material and methods. A total of 53 men aged 30 to 50 years were examined, who after a comprehensive examination were diagnosed with chronic abacterial prostatitis. To confirm the viral etiology of chronic abacterial prostatitis, the patients underwent an additional specific examination: the determination of serological markers (antibodies (Ig) class IgM and IgG by the ELISA method) and virologic (DNA viruses in prostate secretion and ejaculate by PCR method). To establish the prescription of infection, the avidity index (IA) of IgG antibodies was determined.Results. According to the results of the examination, 16 patients were seronegative. That is, anti-HSV 1/2 IgG classes were detected in 37 patients, which amounted to 69.8%. Among them, IgG against type 1 HSV was detected in 8 patients (21.6%), whereas IgG against type 2 HSV was detected in 29 patients (78.4%). Of all the seropositive 37 patients, high avidity IgG to HSV-1 type was detected in 7 patients (87.5%), and high avidity IgG to HSV-2 was detected in 28 patients, which was 96.6%, respectively. One patient was diagnosed with IgM to HSV 2. The virus DNA was detected in 9 seropositive patients, which was 24.3%. The study of clinical manifestations and specific laboratory markers of herpes infection made it possible to identify their clinical and pathogenetic forms.Conclusion. Considering the data obtained, an algorithm for examining patients with suspected herpetic etiology of chronic abacterial prostatitis is proposed. The main criterion for the diagnosis of chronic abacterial prostatitis of herpetic etiology is the detection of DNA of the virus in the secretion of the prostate and ejaculate by polymerase chain reaction.
Calcium oxalic nephrolithiasis and foundation of its metaphylaxis
Authors: Д. В. Черненко  , В. В. Черненко  , Н. І. Желтовська  , В. Й. Савчук
Published: December 2018

Hypercalciuria is the main lithogenic pathometabolism in calcium nephrolithiasis which manifests with multilateral impairments of metabolic risk factors of recurrent development of kidney stone disease and different types of hypercalciuria. Causes of hypercalciuria can include impairments of gastro-intestinal function, hormonal impairments and their imbalance in the regulation of bone tissue metabolism, impairments of vitamin D metabolism, congenital genetic pathologies and dietary factors.The objective: was to improve the results of anti-relapse treatment of patients with calcium oxalate nephrolithiasis by studying the pathogenetic aspects of hypercalciuria, developing differential diagnostics of hypercalciuria types, determining the main directions of scientifically based metaphylaxis.Materials and methods. The study included 100 patients with calcium oxalate nephrolithiasis (67 men and 33 women). The average age of the patients was 38.5 years. 67 (67%) patients had percutaneous nephrolithotripsy, remote lithotripsy in 13 (13%) patients, contact ureterolithotrypsy in 12 (12%) patients, open surgical interventions in 8 (8%) patients, patients.Results. For performing metaphylaxis of calcium oxalic nephrolithiasis, it is necessary to differentiate types of calcium oxalic nephrolithiasis and choice of adequate treatment. Our study pays attention to absorbent calcium oxalic nephrolithiasis of types I, II, III and IV, renal, resorptive HK and tubular acidosis. There are also presented schemes of metaphylaxis and results of 3-year metaphylaxis of calcium oxalic nephrolithiasis.Conclusion. Metabolic disorders in patients with urolithiasis are polymorphic in character and require a differentiated approach to establish the type of hypercalciuria, which allows scientifically substantiate metaphylactics, correct lithogenous disorders and reduce the risk of recurrent stone formation during a significant period of treatment.
Sexual disorders in men with chronic prostatitis/pelvic pain and lower urinary tract symptoms
Authors: О. С. Федорук  , В. І. Зайцев  , М. С. Степанченко  , І. І. Ілюк
Published: December 2018

Prostatic Pain Syndrome (SPB) is characterized as persistent or recurrent episodic pain associated with negative cognitive, behavioral, sexual or emotional effects, as well as symptoms of lower urinary tract and sexual dysfunction.The objective: evaluation of sexual disorders differences in patients with chronic non-bacterial prostatitis/pelvic pain (CNP) and men with lower urinary tract symptoms.Materials and methods. 80 patients were examined (outpatient setting): 47 with CNP and a control group of 33 men with benign prostatic hyperplasia (BPH). The evaluation of prostate-specific symptoms was performed using I-PSS and NIH-CPSI questionnaires. Sexual disorders evaluated by IIEF questionnaire. The reliability of group differences for entities subject to normal distribution was estimated using Student’s criterion.Results. The I-PSS average score was significantly higher in the BPH group. The NIH-CPSI average score was significantly higher in the main group. Erectile dysfunction was detected in 29.8% of patients with CNP and in 72,7% of patients with BPH. Ejaculation disorders were reported by over 80% of the examined patients, no significant difference between groups found. Only 12.8% of CNP patients reported satisfactory libido (57.6% in BPH group). Overall sexual satisfaction was similar between the groups: 10.6% versus 42.4% of respondents respectively.Conclusions. Chronic non-bacterial prostatitis, regardless of type, was associated with significantly more severe disorders. Additional studies need to be planned to found the reasons for that discrepancies.
Differential diagnosis of hypercalciuria and its role in the meta-prevention of calcium-oxalate nephrolithiasis
Authors: В. В. Черненко  , Д. В. Черненко  , В. Й. Савчук  , Н. І. Желтовська  , Ю. М. Бондаренко
Published: December 2018

The course of the most prevalent СaOx nephrolithiasis is accompanied by hypercrystallization, which is a high risk of relapsing CKD. For conducting scientifically grounded metaphilactics, it is necessary to distinguish the types of crystallization. We offer tests:1. Low calcium test – used for hypercalciuria: within 3 days, the patient is assigned a low calcium diet followed by a determination of the level of calcium in the daily urine. Reducing the level of calcium to the norm indicates the presence of an absorbent form of hypercalciuria of type II. The reason is hyperabsorption of Ca from the intestine. In metaphilactics it is necessary to recommend to the patient a low calcium diet. In cases of lack of hypercalciuria, a diagnosis of hypercalciuria I type (non-absorption) is presented and is associated with a violation of enzymatic activity of the liver.2. Calcium test (absorbent hyperoxaluria). Results of the study of daily urine on the content of stone-forming salts revealed in 25–30% of cases high levels of oxalurium (76––114 mg/l at a rate of 35–40 mg/l) with normal calciuria. Hyperoxaluria is an aggressive hypercrystallization factor, the level depends on the used diet, absorption in the intestine. The activity of absorption of oxalate depends on calcium, which binds the oxalate and translates into insoluble form, thus preventing absorption.Calcium test: 3 calcium 0,5 gluconate (3 days). The control of daily urine – oxaluria comes to the upper limit of the norm (38-45 mg/l), we diagnose absorbent hyperoxaluria. In metaphysics of CaOx, nephrolithiasis with pronounced hyperoxaluria shows calcium diet.3. Thiazide test – is conducted at elevated rates of parathormone with hypercalciuria and hyperuricemia. Within 5–7 days, thiazide diuretics are prescribed: hydrochlorothiazide 50 mg – 1 g/day, or chlorthalidone 50 mg 2 g/day, or chlorothiazide 4 mg 1 g/day, with the determination of the level of calcium in the blood and urine. With an increase in the level of hypercalcemia, we diagnose the resorptive form of hypercalciuria (primary hyperparathyroidism). Consultation of an endocrinologist on resection of parathyroid glands and further treatment.Initiated differential diagnosis of hypercalciuria makes it possible to scientifically substantiate the antirecurring treatment of the most prevalent CaOx nephrolithiasis with high efficiency and a percentage (92–95%) of the non-recurring period during 5 years of metaphilactics.
Features of therapy of resistant forms of chlamydial infection
Authors: М. Е. Запольський  , М. М. Лебедюк  , Н. Б. Прокоф’єва  , А. В. Добровольська
Published: December 2018

The objective: the analysis of the effectiveness of treatment of resistant forms of urogenital chlamydia in using a combination of antibiotic therapy with an inducer of endogenous interferon Overseen.Materials and methods. 38 men with urogenital chlamydiosis, in combination with chronic prostatitis, were examined. Patients were divided into groups. The main group included 20 patients, in the comparison group – 18 patients, in the control group – 20 practically healthy men. All patients before and after treatment were monitored for clinical, biochemical, immunological parameters of blood. The main group (20 patients) received antibacterial therapy in combination with Overin (250 mg IM once a day, every other day, only 10 injections). Patients in the comparator group received standard doxycycline therapy of 200–400 mg per day for 14 days.Results. After the treatment of urogenital chlamydia, the immune parameters of the blood improved to a greater extent in patients receiving an endogenous interferon inducer. Control of cure of patients who participated in the study was performed 30 and 60 days after the completion of etiotropic therapy. In patients of the main group who additionally received Overin, elimination of the pathogen was achieved in 95% of cases, in the comparison group this indicator was 88.8%. 30 days after the treatment, only 2 (10%) patients in the main group maintained dysuric syndrome, while in the group comparing the increase in urination was noted in 6 (33.3%) patients. Chronic pain in the pelvic organs after treatment was maintained in 1 (5%) of the patients in the primary group and in 3 (16.6%) patients in the comparison group.Conclusion. The use of Overin in combination with antibacterial agents increases the effectiveness of the treatment of resistant forms of urogenital chlamydia and accelerates the regression of dysuric phenomena and pain in pelvic organs associated with chronic prostatitis. Overin is well tolerated by patients and does not have clinically significant side effects.
Immune factors in the pathogenesis of inflammatory and non-inflammatory forms of chronic abacterial prostatitis
Authors: І. І. Горпинченко  , К. Р. Нуріманов  , В. С. Савченко  , Т. В. Порошина  , Г. М. Драннік
Published: December 2018

Features of the pathogenesis of inflammatory and non- inflammatory forms of chronic abacterial prostatitis (СAP) – the subject of modern scientific discussion.The objective: to study the role of immune parameters in the pathogenesis of СAP to identify new differential signs of inflammatory and non-inflammatory forms of forms.Materials and methods. 42 patients with chronic abacterial prostatitis were examined. 30 healthy men made up a control group. The production of cytokines in the blood and ejaculate was determined by an enzyme immunoassay.Results. It has been established that chronic abacterial inflammation of the prostate gland is accompanied by a significant increase in the serum concentration of SLPI, IL-8, TNF-α, IL-17 in the seminal plasma and serum concentration, and a decrease in the concentration of IL-6 and TGF-β1 compared to healthy men (p<0,05). There was no statistically significant difference between SLPI, IL-8, TNF-α, IL-23, IL-17, and TGF-β1 in the ejaculate of patients with inflammatory and non-inflammatory forms of CAP (p<0,05). The concentration of IL 6 in ejaculate in patients with inflammatory form of CAP is significantly greater than in patients with inflammatory form of CAP (p=0,010).Conclusions. The inflammatory and non inflammatory forms of CAP are pathogenetically similar to changes in the concentration of the studied cytokines except for IL-6. In both forms there are signs of inflammation. In this connection, it is proposed to use the terms «leukocytic» and «nonleukocytic» CAP.
Application of osmotically active drugs in diabetic patients with acute stroke
Authors: О. А. Галушко
Published: December 2018

Osmotically active drugs are widely used in patients with acute stroke (AS), among which a special place is occupied by patients with concomitant diabetes mellitus (DM). The article discusses the features of the treatment of edema and cerebral swelling and known complications in the use of osmotic drugs, in particular mannitol, in this category of patients.The objective: to determine the effectiveness of using mannitol solution in diabetic patients with AS.Materials and methods. An analysis of the treatment of 416 patients with AS was conducted, most of which were administered mannitol (402 of 416 patients, or 96,63%).Results. It was found that electrolyte disturbances were frequently observed in patients who received infusion of mannitol. In general, one or another type of electrolyte disturbances was detected in 73,9% of cases (258 of 349 patients who were on treatment for more than 7 days).Conclusions. The unbalance of exchange of sodium and potassium was most common. As a result of the review of literature and analysis of own experience, a compromise solution to the problem of the use of mannitol in diabetic patients with AS was proposed.
Study of treatment effectiveness of patients with chronic nonbacterial prostatitis
Authors: В. І. Тріщ
Published: December 2018

The objective: Studying of level of essential microelements (Zinc, Copper, Magnesium, Iron) in blood and ejaculate, specialty of antioxidant and immune defense of the patients with chronic nonbacterial prostatitis and reasoning of polymicroelemental and immunomodulat ing medication use.Materials and methods. Under supervision were 120 patients with chronic nonbacterial prostatitis, among them 60 patients with inflammatory chronic pelvic pain syndrome (ICPPS – category IIIA) and 60 patients with noninflammatory chronic pelvic pain syndrome (NCPPS – IIIB). Microelements in whole blood and ejaculate were determined using  atomic absorption spectrophotometry on C 115 PC. State of antioxidant defense was judged considering quantification of Catalase after A. Bach and S.Zubkova and Superoxide Dismutase. Immune status was analyzed in accordance to the results of determination of the interleukins-6, -8 (IL-6, IL-8) concentration and quantification of tumor necrosis factor-alpha (α-TNF) in blood serum, using the set of company “VECTOR-BEST”, by immunoassay analysis. Correction of violations of bioelemental status and immune defense was conducted by prescription except the standard therapy the polyelemental complex and interferon alpha-2b.Results. A certain decrease of microelements Zn, Fe, Mg and Cu increase were observed in both groups of patients with chronic nonbacterial prostatitis. Also it was noted that with long duration of chronic nonbacterial prostatitis takes place the antioxidant enzymes level decrease. It was noted a visible concentrations increase of proinflammatory cytokines in blood of both groups of patients with chronic nonbacterial prostatitis. Especially significant increase in serum was IL-8. Under influence of treatment was noted positive dynamics of improve ment of bioelemental consist of blood and ejaculate, increase of antioxidant enzymes level and decrease of proinflammatory cytokines concentration in blood of patients with chronic nonbacterial prostatitis.Conclusion. With chronic nonbacterial prostatitis was observed decrease of Zinc, Iron, Magnesium and increase of Copper level in blood as well as in ejaculate of the patients. Metabolic changes with shortage of Zn and excess of Cu correlate with antioxidant system disbalance , that is with antioxidant defense level decrease. With chronic nonbacterial prostatitis was observed increase of proinflammatory cytokines concentration, especially in patients with inflammatory chronic pelvic pain syndrome.Inclusion of polyelemental complex and interferon alpha-2b in complex treatment of the patients with nonbacterial chronic prostatitis improves macro and microelemental status of blood and ejaculate, thereby strengthens antioxidant and immune defense.
On the advisability of reinforcing pathogenetically substantiated medication prophylaxis for complications after surgical treatment of prostatic hyperplasia
Authors: М. І. Ухаль
Published: December 2018

The objective: to analyze the results of the operative treatment of benign prostatic hyperplasia (BPH) after application in the postoperative period, along with traditional drug therapy, of a modern complex preparation modulating complications caused by the disease and surgical intervention.Materials and methods. The study involved 54 patients with BPH aged 65 to 80 years (mean age 66.5 years). Patients were divided into two groups. The first group included 34 patients with BPH, who underwent traditional medical treatment. The second group consisted of 24 patients with BPH who, along with traditional medical therapy, starting from the 5th 6th day after the operation, were prescribed a complex preparation of pravenor forte.Results. In the morphological study of drugs from the removed hyperplastic tissues of the prostate, the presence of a chronic bacterial inflammatory process was confirmed in all operated patients with BPH. In a comparative analysis of the effectiveness of treatment in patients of the two groups, it was found that the development in the postoperative period of an acute infectious inflammatory process in the organs of the urinary system in the form of acute cystitis and ascending pyelonephritis was noted more often in patients of the comparison group.The conclusion. The use of postoperative prostatic hyperplasia (RV) after surgical treatment along with traditional drug therapy of the modern complex preparation of pravenor forte significantly reduces the incidence of postoperative complications and creates conditions for restoring the changes caused by hyperplasia of the prostate.