bluuebunny/crossref_metadata_2025 huggingface dataset:
[Retracted] Evaluation of Innovation Efficiency of High‐Tech Enterprise Knowledge Supply Chain Based on AHP‐DEA
Authors: Han Huiyuan , Gu Xiaomin
Published: February 2022

This paper introduces a qualitative analysis on the efficiency evaluation of the knowledge supply chain by combining the analytic hierarchy process (AHP) with data envelopment analysis (DEA), drawing on existing literature to determine the index weight through the scoring of industry experts, and selecting appropriate input and output indicators to construct a knowledge supply chain efficiency evaluation system. The system was then applied to the supply chain of a number of high‐tech enterprises. The results identified innovation efficiency differences of the knowledge supply chain in these enterprises, along with best practices and suggestions for the current knowledge supply chain efficiency.
Ajuba Overexpression Promotes Breast Cancer Chemoresistance and Glucose Uptake through TAZ‐GLUT3/Survivin Pathway
Authors: Li Xiang , Zhao Gexin , Mi Xiaoyi , Xu Tonghong , Li Xinmin , Liu Bin
Published: February 2022

The LIM protein Ajuba has been implicated in the development of human cancers. To date, its expression pattern and biological significance in breast cancers (BC) have not been fully investigated. In the current study, we examined Ajuba protein levels in 93 invasive ductal carcinoma specimens by immunohistochemistry. The Ajuba expression level was elevated in breast cancer tissue compared with normal tissue. Ajuba overexpression is correlated with advanced tumor‐node‐metastasis (TNM) stage, positive node status, and adverse patient outcomes. The Ajuba protein level was also higher in BC cell lines compared to normal breast epithelial cell line MCF‐10A. Ectopically expressed Ajuba in MCF‐7 cells stimulated in vitro and in vivo cell growth, invasion, cell cycle progression, and decreased paclitaxel‐induced apoptosis. RNA‐sequencing (RNA‐seq) followed by gene set enrichment analysis (GSEA) analysis showed that Ajuba overexpression regulated the Hippo signaling pathway. Ajuba overexpression also increased glucose uptake and increased expression of TAZ, GLUT3, and Survivin. TAZ knockdown abolished the role of Ajuba on GLUT3 and Survivin induction. The ChIP assay showed that TEAD4, a major TAZ binding transcription factor, could bind to the GLUT3 and Survivin promoter regions. In conclusion, our data demonstrated that elevated Ajuba expression is correlated with poor BC prognosis and regulated malignant behavior through TAZ‐GLUT3/Survivin signaling in BC cells.
Management Outcomes in Pediatric Keratoconus: Childhood Keratoconus Study
Authors: Gupta Yogita , Saxena Rohit , Jhanji Vishal , Maharana Prafulla K. , Sinha Rajesh , Agarwal Tushar , Titiyal Jeewan S. , Sharma Namrata
Published: February 2022

Introduction. The Global Delphi Panel of Keratoconus (KC) and Ectatic Diseases formulated management guidelines for KC in 2015. The aim of this study was to evaluate management outcomes in pediatric KC. Materials and Methods. Prospective, interventional study was conducted at a tertiary care hospital including KC patients aged <18 years. Based on disease severity and progression of disease, patients were prescribed either glasses or contact lenses (CLs) or underwent corneal collagen crosslinking (CXL), deep anterior lamellar keratoplasty (DALK), or penetrating keratoplasty (PK). Main Outcome Measures. Best corrected visual acuity (BCVA), manifest cylinder, maximum keratometry, thinnest corneal thickness, total higher order aberrations, and corneal hysteresis at baseline and 12 and 24 months. Results. 116 eyes of 62 patients with a mean age of 14.76 ± 2.77 years were included. 32.8% of the eyes (n = 38) achieved satisfactory BCVA with glasses/CLs only. Corneal collagen crosslinking (CXL) was performed in 43.1% of the eyes (n = 50) with progressive KC and halting of progression was noted in 83.3% (n = 35) of the eyes at 2 years. 7.7% of the eyes (n = 9) were managed for acute hydrops. DALK and PK were successfully performed in 9.5% (n = 11) and 6.9% (n = 8) of the eyes with BCVA of 0.14 ± 0.09 and 0.08 ± 0.12 at 2 years, respectively. Conclusions. Pediatric KC cases with progression show good visual and aberrometric outcomes and halting of progression after CXL. DALK and PK have good outcomes. The global consensus guidelines showed good clinical utility in pediatric patients. Presence of VKC did not have an impact on the outcomes of CXL in pediatric patients.
Effects of Dietary Phospholipid and Cholesterol Levels on Growth, Molting Performance, and Ovary Development in Female Juvenile Crayfish (Procambarus clarkii)
Authors: Hou Shouquan , Zhu Shaicheng , Li Jinghao , Huang Jin , Li Jiayao , Cheng Yongxu
Published: February 2022

The interaction between phospholipid (PL) and cholesterol (CH) on growth performance, molting rate, hepatopancreas fatty acid composition, and ovary development of the female red swamp crayfish (Procambarus clarkii) was investigated. Nine diets containing three PL levels (0, 20, and 60 g/kg) and three CH levels (0, 5, and 10 g/kg) were included in the study. Female crayfish (initial weight:

5.92
±
0.03

 g) were reared for 60 days. There was no significant interaction between dietary PL and CH levels (

P
>
0.05

). However, the best growth performance and ovarian development were observed in crayfish receiving the 60 g/kg PL and 10 g/kg CH diet. High PL levels promoted CH transport in the hepatopancreas, and long-chain unsaturated fatty acid (C20:4n-6, C20:5n-3, and C22:6n-3) content of the hepatopancreas increased with the addition of PL in the diet. The molting rate increased with increasing CH levels in the diet containing 60 g/kg PL. Real-time quantitative polymerase chain reaction revealed that dietary CH enhanced the molting rate by improving the ecdysone receptor genes at transcription. This study showed that crayfish fed a diet containing 10 g/kg CH and 60 g/kg PL obtained maximum growth, molting rate, and ovary development.
Delayed Admission to the Intensive Care Unit and Mortality of Critically Ill Adults: Systematic Review and Meta‐analysis
Authors: Kiekkas Panagiotis , Tzenalis Anastasios , Gklava Vasiliki , Stefanopoulos Nikolaos , Voyagis Gregorios , Aretha Diamanto
Published: February 2022

Delayed admission of patients to the intensive care unit (ICU) is increasing worldwide and can be followed by adverse outcomes when critical care treatment is not provided timely. This systematic review and meta‐analysis appraised and synthesized the published literature about the association between delayed ICU admission and mortality of adult patients. Articles published from inception up to August 2021 in English‐language, peer‐reviewed journals indexed in CINAHL, PubMed, Scopus, Cochrane Library, and Web of Science were searched by using key terms. Delayed ICU admission constituted the intervention, while mortality for any predefined time period was the outcome. Risk for bias was evaluated with the Newcastle‐Ottawa Scale and additional criteria. Study findings were synthesized qualitatively, while the odds ratios (ORs) for mortality with 95% confidence intervals (CIs) were combined quantitatively. Thirty‐four observational studies met inclusion criteria. Risk for bias was low in most studies. Unadjusted mortality was reported in 33 studies and was significantly higher in the delayed ICU admission group in 23 studies. Adjusted mortality was reported in 18 studies, and delayed ICU admission was independently associated with significantly higher mortality in 13 studies. Overall, pooled OR for mortality in case of delayed ICU admission was 1.61 (95% CI 1.44‐1.81). Interstudy heterogeneity was high (I2 = 66.96%). According to subgroup analysis, OR for mortality was remarkably higher in postoperative patients (OR, 2.44, 95% CI 1.49‐4.01). These findings indicate that delayed ICU admission is significantly associated with mortality of critically ill adults and highlight the importance of providing timely critical care in non‐ICU settings.
In Vitro Antilipidic and Antithrombotic Activities of Plectranthus glandulosus (Lamiaceae) Leaves Extracts and Fractions
Authors: Zouheira Djamila , Ngnokam Sylvie Lea Wansi , Kamani Sylviane Laure Poualeu , Tchegnitegni Billy Toussie , Jouda Jean Bosco , Mba Jean Romuald , Nchouwet Moïse Legentil , Nfor Njini Gael , Nyirimigabo Alain K. , Kowa Théodora Kopa , Agbor Gabriel A.
Published: February 2022

Objective. The present study investigated the effect of the leaves extracts and fractions of Plectranthus glandulosus on the inhibition of pancreatic lipase, cholesterol esterase, adipocytes lipid uptake, and antithrombotic activity which may be important in atherosclerosis development. Methods. Aqueous, ethanolic, and hydroethanolic extracts of Plactranthus glandulosus were prepared by maceration. The hydroethanolic extract was fractionated into n‐hexane, ethylacetate, and n-butanol fractions and their inhibition of pancreatic lipase, cholesterol esterase, adipocytes lipid uptake, and antithrombotic activities measured. Liquid chromatography‐high resolution mass spectrometry (LC‐HRMS) analysis was carried out to determine phytochemical constituents present in the extracts. Results. The standard orlistat exhibited a higher inhibitory activity on pancreatic lipase and cholesterol esterase (16.31 μg/mL and 15.75 μg/mL, respectively) compared to ethyl acetate fraction (IC50, 17.70 μg/mL and IC50, 24.8 μg/mL, respectively). Among crude extract, hydroethanolic extract showed a better inhibition against pancreatic lipase (IC50, 21.06 μg/mL) and cholesterol esterase (IC50, 25.14 μg/mL) though not comparable to the effect of orlistat. The best lipid uptake inhibition was observed in the hydroethanolic extract (IC50, 45.42 μg/mL) followed by the ethyl acetate fraction (IC50, 47.77 μg/mL). A better antithrombolytic activity was exhibited by the ethyl acetate fraction at all concentrations (50‐800 μ/mL), while hydroethanolic extract exhibited the best activity among crude extract. However, these were not comparable to the standard aspirin. The LC‐HRMS analysis revealed the presence of 7‐O‐methyl luteolin 5‐O‐β‐D‐glucopyranoside, chrysoeriol 5‐O‐β‐D‐glucopyranoside, 5,7‐dihydroxy‐3,2 ′,4 ′‐trimethoxyflavone, and plectranmicin as major compounds in both hydroethanolic extract and ethyl acetate fraction. Conclusion. Thus, our finding supports the traditional use of this plant, which might provide a potential source for future antiatherosclerotic drug discovery.
Mental and Emotional Recognition of College Students Based on Brain Signal Features and Data Mining
Authors: An Shaobo , Yu Zhifen
Published: February 2022

Nowadays, people pay more and more attention to the psychological situation of college students. Using data mining technology to model and analyze the collected psychological data of college students is a research hotspot in psychology and computer science. In addition, the essence of human emotional change is the higher nervous activity in the cerebral cortex. Electroencephalography (EEG) has become an important feature signal for emotion recognition because of its high time resolution and portability and practicality. Therefore, to solve the problem that the accuracy and generalization of the existing research models are not ideal, a method of college students’ psychological emotion recognition based on EEG signal features and data mining is proposed. Firstly, a feature selection method based on sparse learning is used to find out a few features from the high-dimensional feature space that contribute greatly to the reconstruction of category information so as to quickly acquire a few key emotion-related features. Then, the entropy-weighted clustering algorithm is combined with sparse learning feature selection, and the local structure of heterogeneous data is divided. Experimental results show that, compared with traditional methods, the proposed method has stronger applicability and higher accuracy of five categories of emotions, which provides a valuable reference for the evaluation of depression and anxiety of college students based on brain signal characteristics.
The Predictive Value of ACR TI-RADS Classification for Central Lymph Node Metastasis of Papillary Thyroid Carcinoma: A Retrospective Study
Authors: Zhong Minying , Zhang Zhaoming , Xiao Yisheng , He Yanping , Chen Yongyu , Huang WeiJun , Lu Liping
Published: February 2022

Background. The aim of this retrospective study was to evaluate the risk factors for central lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC), according to the guidelines of the 2017 Thyroid Imaging Report and Data System (TI-RADS) published by the American College of Radiology (ACR). Methods. This study included a retrospective analysis of 844 patients with PTC who were pathologically diagnosed, treated with central lymph node dissection, and divided into CLNM and nonmetastatic groups. Univariate and multivariate analyses were performed to determine the relationship between the TI-RADS score and CLNM. Results. Among 844 patients, 439 developed CLNM, with a metastasis rate of 52% and a TI-RADS score of 9.42 ± 2.262, which were higher than those of the non-CLNM group (

P
<
0.05

). Univariate analysis demonstrated that the sex, location, maximum diameter of the nodule, multifocality, margin, shape, calcification, and TI-RADS score were related to CLNM (

P
<
0.05

for all). However, multivariate logistic regression analysis demonstrated that female, maximum diameter of the nodule, multifocality, a taller-than-wide shape, and high TI-RADS score were the independent risk factors for CLNM (

P
<
0.05

for all). Conclusion. The TI-RADS score combined with sex, nodule size, shape, and multifocality has a certain predictive effect on CLNM, which can provide a reference to the clinicians for further treatment strategies.
Exergy Performance Investigation of Eco-Friendly Refrigerant Mixtures as an Alternative to R134a in a Domestic Refrigerator
Authors: Baskaran A. , Manikandan N. , Tesfaye Jule Leta , Nagaprasad N. , Krishnaraj Ramaswamy
Published: February 2022

In this paper, various eco-friendly refrigerant mixtures R430A, R436A, R436B, R435A, and R510A used in vapour compression refrigeration systems are considered for this study. All of them have zero ODP and very low GWP. On the basis of exergy features, the efficiency of various working fluids in vapour compression refrigeration cycles was compared. The exergy efficiency of mixtures is evaluated for various evaporating temperatures ranging from -40°C to -5°C at a constant condensation temperature of 45°C. The variation of exergy is also analyzed for various condensation temperatures ranging from 25°C to 60°C at a constant evaporating temperature of -10°C. The exergy losses in various components are computed and presented in Grassmann diagrams for a cooling load of 1 kW. The results indicate that all the investigated alternative refrigerant mixtures have higher exergy efficiency than R134A. The maximum exergy performance is 39.72% observed for the mixture R435A at an evaporation temperature of -30°C, and this value is 9.89% higher than that of R134a.The results also show that the highest and lowest exergy losses have occurred in the compressor and evaporator.
Quantitative Proteomics Reveals the Role of Lysine 2-Hydroxyisobutyrylation Pathway Mediated by Tip60
Authors: Wang Ning , Jiang Yue , Peng Ping , Liu Guobin , Qi Shankang , Liu Kun , Mei Qi , Li Jian
Published: February 2022

Lysine 2-hydroxyisobutyrylation (Khib) is a new type of posttranslational modifications (PTMs) extensively reported on eukaryotic cell histones. It is evolutionarily conserved and participates in diverse important biological processes, such as transcription and cell metabolism. Recently, it has been demonstrated that Khib can be regulated by p300 and Tip60. Although the specific Khib substrates mediated by p300 have been revealed, how Tip60 regulates diverse cellular processes through the Khib pathway and the different roles between Tip60 and p300 in regulating Khib remain largely unknown, which prevents us from understanding how this modification executes its biological functions. In this study, we report the first Khib proteome mediated by Tip60. In total, 3502 unique Khib sites from 1050 proteins were identified. Among them, 536 Khib sites from 406 proteins were present only in Tip60 overexpressing cells and 13 Khib sites increased more than 2-fold in response to Tip60 overexpression, indicating that Tip60 significantly affected global Khib. Notably, only 5 of the 549 Tip60-targeted Khib sites overlapped with the 149 known Khib sites targeted by p300, indicating the different Khib substrate preferences of Tip60 and p300. In addition, the Khib substrates regulated by Tip60 are deeply involved in processes such as nucleic acid metabolism and translation, and some are associated with Parkinson’s and Prion diseases. In summary, our research reveals the Khib substrates targeted by Tip60, which elucidates the effect of Tip60 in regulating various cellular processes through the Khib pathway, and proposes novel views into the functional mechanism of Tip60.
Visual Simulation of Modern Supply Chain Based on MR Virtual Reality Technology
Authors: Yang Jin
Published: February 2022

In order to improve the management and operation efficiency of the modern supply chain, this paper combines the MR virtual reality technology to carry out the visual simulation of the modern supply chain. Moreover, this paper uses MR virtual simulation technology to perform intelligent perception of supply chain transportation equipment and transportation objects, recognize its shape and the force it receives, and ensure that there is no damage during the transportation process. The visual simulation of supply chain is realized by real-time dynamic display based on geometric model. Moreover, this paper combines the MR virtual reality technology to define the geometric and kinematic characteristics of the modeled object, then encapsulates these characteristics into the object class, and defines the behavior characteristics to establish an object class library. Finally, the experimental research verifies that the modern supply chain visual simulation technology based on MR virtual reality technology has a good simulation effect in the supply chain system.
First Report of the HEV Seroprevalence and the Risk Factor Assessment in the West Bank, Palestine, during the Period of 2015–2017
Authors: Dumaidi Kamal , Abudamous Alaa M. , Abu-Helu Rasmi , Al-Jawabreh Hanan , Dumaidi Yazan , Al-Jawabreh Amer
Published: February 2022

Hepatitis E virus is emerging viral hepatitis with hyperendemicity in many countries. Data on the burden of disease is not available in Palestine. This study aims to determine the seroprevalence and the risk factors of the HEV among the general population of the West Bank, Palestine. In this cross-sectional study, a total of 432 sera samples from 40 localities in the eleven districts of the West Bank and Jerusalem, Palestine, during the period of March 2015 to March 2017, were tested for HEV-IgG. A structured questionnaire was used to collect data of the participants’ demographics and disease risk factors. The overall seroprevalence was 3.7%. Level of education was significantly inversely associated with HEV seropositivity (

P
=
0.04

). Purely spatial analysis did not detect any significant cluster related to the distribution of HEV-IgG cases; however, living in the southern West Bank is shown to be significantly associated with HEV. Age was also associated with HEV seropositivity. The young (<19 years) and adults (>40 years) had the highest prevalence, compared to those between 20 to 39 years old (

P
=
0.12

). Furthermore, males and those in contact with animals were associated with HEV seropositivity (

P
=
0.1
 and 
0.3

, respectively). In conclusion, the seroprevalence of HEV IgG in the West Bank, Palestine is low. Several well-investigated risk factors cannot be supported by our results due to the small number of the positive HEV-IgG samples. Finally, this study is useful for providing a first look into the seroepidemiology of HEV in Palestine.
Big Data-Driven Hierarchical Local Area Network Security Risk Event Prediction Algorithm
Authors: Zhou Wei
Published: February 2022

Big data processing technology has attracted a lot of attention due to its forecasting and warning of Internet security situation. The current risk assessment system still has problems such as high false alarm rate and excessive reliance on expert knowledge in the security defense system. Based on the big data-driven principle, this paper constructs a hierarchical local area network security risk event prediction model and proposes a predictive complex event processing method. The model building process is evolved and improved on the basis of the scoring function. The establishment method of vulnerability database and vulnerability association database is introduced in detail. At the same time, the problem of the difference between the structure and identification method of the information in the information database and the vulnerability database is solved, and the effect of timely modification when the data do not match is realized. Experimental results show that the algorithm has an accuracy of 98.75% and a fault tolerance rate of 0.0035, which promotes the accuracy of the network risk assessment results based on multistage network attacks.
High‐Resolution Computed Tomography Scores in Cases of Bronchopulmonary Dysplasia
Authors: Akcan Abdullah Barıs , Oygucu Seyhan Erişir , Arslan Ahmet Gökhan , Özel Deniz , Oygür Nihal
Published: February 2022

Background. Bronchopulmonary dysplasia (BPD) carries a risk of long‐term pulmonary sequelae. High‐resolution computed tomography (HRCT) is a method of detecting such structural changes. This study is aimed at characterizing structural abnormalities associated with BPD and at evaluating the clinical findings in the newborn period associated with HRCT scores. Methods. 28 patients born with a mean gestation age of 30 ± 2.9 weeks and diagnosed as BPD in their neonatal period were reevaluated when they were between the postnatal ages of 6 and 12 months. HRCT was performed in 20 patients with a history of moderate and severe BPD. Scans were interpreted by one radiologist using a scoring system. Results. Patients were 9.8 ± 2.3 months at the time of reevaluation. The average HRCT score of patients was, respectively, 7.20 ± 4.05 with moderate and 7.40 ± 2.84 with severe BPD. The difference between them was not significant (p = 0.620). When moderate and severe groups were collected as a whole on the basis of physical findings and drug treatment, 6 had normal physical examination findings, no oxygen and no drug requirement; 14 had at least one finding at the time of reevaluation. No significant difference was detected in terms of HRCT score between the two groups (6.50 ± 3.83 versus 7.64 ± 3.30). Conclusions. More studies are needed in terms of the role of HRCT in the assessment of BPD prognosis. A contemporary definition of BPD that correlates with respiratory morbidity in childhood is needed. Also, a new lung ultrasound technique for predicting the respiratory outcome in patients with BPD can be used instead of HRCT.
Identification of Two Novel Mutations of ABCD1 Gene in Pedigrees with X-Linked Adrenoleukodystrophy and Review of the Literature
Authors: Dong Bingzi , Lv Wenshan , Xu Lili , Zhao Yuhang , Sun Xiaofang , Wang Zhongchao , Cheng Bingfei , Fu Zhengju , Wang Yangang
Published: February 2022

Background. X-linked adrenoleukodystrophy (ALD) is an inherited peroxisomal metabolism disorder, resulting from the loss-of-function mutation of ATP-binding cassette protein subfamily D1 (ABCD1) gene. The dysfunction of ALD protein, a peroxisomal ATP-binding cassette transporter, results in the excessive saturated very long-chain fatty acids (VLCFAs) accumulation in organs including the brain, spine, and adrenal cortex. X-ALD is characterized as the childhood, adolescent, adult cerebral ALD, adrenomyeloneuropathy (AMN), adrenal insufficiency, and asymptomatic phenotypes, exhibiting a high variety of clinical neurological manifestations with or without adrenocortical insufficiency. Results. In this study, we reported two cases of X-ALD, which were first diagnosed as adrenal insufficiency (Addison’s disease) and treated with adrenocortical supplement. However, both of the cases progressed as neurological symptoms and signs after decades. Elevated VLCFAs level, brain MRI scan, and genetic analysis confirmed final diagnosis. In addition, we identified two novel mutations of ABCD1 gene, NM_000033.3 (ABCD1): c.874_876delGAG (p.Glu292del) and NM_000033.3 (ABCD1): c.96_97delCT (p.Tyr33Profs

∗

161), in exon 1 of ABCD1 gene. Sanger sequencing confirmed that the proband’s mother of the first case was heterozygous carrying the same variant. Adrenal insufficiency-only type is very rare; however, it may be the starting performance of X-ALD. In addition, we summarized reported mutation sites and clinical manifestations to investigate the correlationship of phenotype-genotype of X-ALD. Conclusions. The early warning manifestations should be noticed, and the probability of X-ALD should be considered. This report could be beneficial for the early diagnosis and genetic counseling for patients with X-ALD.
Cytotoxic and Antioxidant Effects of Phoenix dactylifera L. (Ajwa Date Extract) on Oral Squamous Cell Carcinoma Cell Line
Authors: Shahbaz Khushboo , Asif Jawaad Ahmed , Liszen Tang , Nurul Asma Abdullah , Alam Mohammad Khursheed
Published: February 2022

Aim. The aim of the current study is to investigate the antioxidant and apoptotic potential of Ajwa date flesh (ADF) and Ajwa date pit (ADP) extract on human squamous cell carcinoma cell line (HSC‐2). Method. ADF and ADP were extracted with a solvent extraction method using hexane, acetone, and ethanol, which were then subjected to antioxidant assay by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH). HSC‐2 cells were then treated with different concentrations of ADF and ADP extract for 24, 48, and 72 hours. MTT assay was performed to assess the antiproliferative effect, and Annexin V‐FITC was used for the detection of cellular apoptosis. Results. Acetone extracts of ADF and ADP had the highest radical scavenging and antioxidant activities followed by the ethanolic extracts, whereas ADP appeared to have significantly higher antioxidant effects than ADF. MTT assay demonstrated that acetone extracts of ADF and ADP were significantly cytotoxic against HSC‐2 cells in a dose‐ and time‐dependent manner. The half inhibitory concentration (IC50) of ADF was found to be 8.69 mg/ml at 24 h, and the maximum cell growth inhibition was observed at 50 mg/ml. The IC50 for the ADP was found to be 0.97 mg/ml at 24 h, and the maximum cell growth inhibition was observed at 5 mg/ml. Statistical analysis of the flow cytometry assay showed that the treatment with ADF and ADP extracts had a significant apoptotic effect which occurred in a dose‐dependent manner. HSC‐2 cells were seen in the late apoptotic stage with higher doses of ADF and ADP extract. ADP extract demonstrated higher apoptotic activity than ADF extract. In addition, combined treatment of ADF and ADP was also performed on HSC‐2 cells which demonstrated higher apoptotic activity when compared to the single extract. Conclusion. Ajwa date fruit has a promising cytotoxic effect by inhibiting the growth and proliferation of OSCC cells and inducing cell death by apoptosis.
A System of Remote Patients’ Monitoring and Alerting Using the Machine Learning Technique
Authors: Dhinakaran M. , Phasinam Khongdet , Alanya-Beltran Joel , Srivastava Kingshuk , Babu D. Vijendra , Singh Sitesh Kumar
Published: February 2022

Machine learning has become an essential tool in daily life, or we can say it is a powerful tool in the majority of areas that we wish to optimize. Machine learning is being used to create techniques that can learn from labelled or unlabeled information, as well as learn from their surroundings. Machine learning is utilized in various areas, but mainly in the healthcare industry, where it provides significant advantages via appropriate decision and prediction methods. The proposed work introduces a remote system that can continuously monitor the patient and can produce an alert whenever necessary. The proposed methodology makes use of different machine learning algorithms along with cloud computing for continuous data storage. Over the years, these technologies have resulted in significant advancements in the healthcare industry. Medical professionals utilize machine learning tools and methods to analyse medical data in order to detect hazards and offer appropriate diagnosis and treatment. The scope of remote healthcare includes anything from tracking chronically sick patients, elderly people, preterm children, and accident victims. The current study explores the machine learning technologies’ capability of monitoring remote patients and alerts their current condition through the remote system. New advances in contactless observation demonstrate that it is only necessary for the patient to be present within a few meters of the sensors for them to work. Sensors connected to the body and environmental sensors connected to the surroundings are examples of the technology available.
Effect of Coffee Husk Compost and NPSB Fertilizers on Selected Soil Chemical Properties of Potato Field in Chora District, South West Ethiopia
Authors: Jibril Temam , Bekele Getachew
Published: February 2022

Field experiment was conducted in Chora District of south western Ethiopia, to evaluate the effect of different rates of coffee husk compost (CHC) and 18.9N + 37.7P + 6.94S + 0.15B (NPSB) in the form of NH4, P2O5, SO4−, and B2O5, repectively, blended fertilizer on selected soil chemical properties of potato field during 2021. The treatment consisted of four rates of CHC (0, 2.5, 5, and 7.5 t ha−1) and four rates of blended NPSB fertilizer (0, 112.5, 150, and 187.5 kg ha−1). The experiment was laid out in randomized complete block design with three replications. Postharvest soil data were collected and subjected to ANOVA using SAS version 9.4. All the soil parameters analyzed were significantly (P<0.05) affected by the main factors of CHC and NPSB blended fertilizer except exchangeable K+ and Na+ which were affected by main factors but not by factors interaction. The maximum pH (5.3), OC (6.0%), and CEC (14.10 meq 100g−1) were obtained from application of sole 7.5.t CHC ha−1 which is at par with combined 7.5.t CHC and 112.5 kg NPSB ha−1, while the maximum TN (26%), Av. P (3.57%), and Av. S (4.36%) were obtained from combined application of 7.5.t CHC and 112.5 kg NPSB ha−1. The sole application of either of 150 kg or 187.5 kg NPSB ha−1 was resulted in high exchangeable acidity. Therefore, combined application of CHC and NPSB fertilizers raised the pH, improves the OC%, total N, available P and S, reduced the exchangeable acidity, and raises the CEC and exchangeable bases of potato field soil as compared to the control and sole NPSB fertilizer.
Study on Two-phase Flow Mechanisms in Nanopore Considering Microcosmic Deformation and Dynamic Capillary Force
Authors: Dou Xiangji , Lin Cong , Hong Sujin , Zhu Pengfei , Wang An , Qi Guodong
Published: February 2022

Coring experiments show that nanopores are extensively distributed in shale oil reservoirs and tend to be deformed when a significant pressure variation exists, and thus the dynamic capillary force phenomenon and flow mechanisms in nanopores can be significantly changed. To characterize the two-phase flow mechanisms in nanopores influenced by the synergistic effect of microcosmic pore deformation and dynamic capillary force, models based on Gassmann’s theory are established to describe the variations of pore radius and roughness in a dynamic pressure field. And then, innovative methods to quantify the dynamic capillary force phenomenon under comprehensive influence of pore size, roughness, and pressure are developed. Meanwhile, mathematical models, considering the effect of the pore deformation and dynamic capillary force, are furtherly derived to characterize the water-oil two-phase flow behavior for relatively large nanopores in shale oil reservoir, which can be used to investigate the influence of the vital parameters. The results indicate that the dynamic capillary force phenomenon turns out to be more significant when variations of pore structure and pressure are considered simultaneously. Moreover, the pore deformation and dynamic capillary force caused by pressure change can exert remarkable synergistic influence on the transport capacity for typical flow modes. Bulk modulus is one of the key factors to determine the degree of influence. An optimal pressure can be obtained to coordinate the competitive effect of seepage channel and capillary force for water-drive-oil mode with limited driving force. Based on that, emphasis should be placed on pressure control during the shale oil development process. This work theoretically underpins the quantitative characterization and the analysis of two-phase flow in shale reservoirs at the nanopore scale.
Virgin Coconut Oil as a New Concept for Periodontal Tissue Regeneration via Expressions of TNF-α and TGF-β1
Authors: Thahir Hasanuddin , Irawaty Djais Arni , Nasir Mansjur , Rahayu Feblina Ayu , Annisa Afdalia , Etriyani Nir , Achmad Harun
Published: February 2022

Background. Virgin coconut oil is a natural product from coconut that has many benefits such as antibacterial, anti-inflammatory, and antioxidant. Inflammatory disease of the periodontal tissues has a high prevalence worldwide. The main etiology of periodontitis plaque of biofilm contains colonies of pathogenic microorganisms. The occurrence of inflammation in the periodontal tissue stimulates the release of inflammatory mediators, such as TNF-α and TGF-β. Treatment for periodontitis can be performed starting from initial therapy and usually accompanied by additional therapy such as local drug delivery. VCO can be used as an alternative to antibiotics. Objective. To determine the effectiveness of VCO gel on periodontal tissue regeneration materials through the expression of TNF-α and TGF-β1. Methods. This is an experimental laboratory with a posttest-only control group design. VCO was made from grated fresh coconut and then mixed with NaCMC to obtain gel viscosity. The subjects of this study were 30 male periodontitis-induced Wistar rats by injecting Porphyromonas gingivalis into the gingival sulcus. Wistar rats were then divided into 3 groups. On the 7th and 14th days, the rats were sacrificed and the jaw was sampled to determine the amount of TNF-α and TGF-β1 expression in the regenerative process of periodontal tissue. Result. The amount of TNF-α and TGF-β1 increased significantly in the treatment group, but not as much as the increase in the positive control and negative control groups. Conclusion. VCO gel can affect the expression of TNF-α and TGF-β1 in the regeneration process of periodontal tissue in periodontitis-induced rats.
Feature Screening via Mutual Information Learning Based on Nonparametric Density Estimation
Authors: Zhou Shengbin , Wang Tao , Huang Yejin
Published: February 2022

With the advent of the era of big data, feature selection in high‐ or ultra‐high‐dimensional data is increasingly important in statistics and machine learning fields. In this paper, we propose a marginal utility measure screening method MI‐SIS based on mutual information. The proposed marginal utility measure has several appealing features compared with the existing independence screening methods. Firstly, the proposed procedure is model‐free without specifying any relationship between the predictors and the response and is valid under a wide range of model settings including parametric and nonparametric models. Secondly, it is suitable for various combinations of the continuous and categorical of predictors and response in our new method. Finally, the new procedure has a good performance in discovering a weak signal in the finite sample and its computation is simple and easy to implement. We establish the sure screening property for the proposed procedure with mild conditions. Simulation experiments and real data applications are presented to illustrate the finite sample performance of the proposed procedures.
Nonlinear Observation and Control of Series Active Power Filters in the Presence of Voltage Sags
Authors: Abouelmahjoub Younes , El Beid Said , Abouobaida Hassan , Chellakhi Abdelkhalek
Published: February 2022

This study addresses the problem of controlling series active power filters for voltage sag compensation. Indeed, we can control this kind of filter to generate a voltage series that compensates the grid voltage sag in order to protect the sensitive loads against this perturbation. This study is aimed at seeking a control strategy that meets the main control objective, which is the compensation of grid voltage sags and this by considering the following technical constraints: (i) the nonlinearity of the system dynamics, (ii) the high dimension of the system model, and (iii) the inaccessibility of some system variables to measurements. To meet the main control objective, we propose a nonlinear controller that is designed based on the system nonlinear model, using the backstepping technique. This controller involves a nonlinear regulator and a grid observer. The former copes with the compensation issue. The observer provides online the grid voltage estimations. In addition to a theoretical analysis of the control system, the performances of the proposed controller are evaluated by simulation using MATLAB/Simulink.
Study on Environmental Art Design Based on Ecology Concept
Authors: Jiang ZiWen , Wang Feng
Published: February 2022

Ecological design concept is a design concept aimed at advocating green environmental protection and sustainable development, which is widely used in different cases of environmental design including urban and kindergarten. In our study, using literature research, case reference, and field research as research methods, through the theoretical research of domestic and foreign kindergarten environment design and interpretation of typical cases to summarize the ecological design method and design strategy, can be further applied in larger field such as urban, basin, and/or region. Then, take “Chenguang” kindergarten in Beijing as example to analyze ecological element in there. Aiming at ecological landscape, ecological humanities, and ecological experience as the goal, the kindergarten’s architectural appearance and indoor and outdoor environment have been transformed and redesigned. Ecological principle and ecological strategy from our study present an important reference meaning in improving the quality of urban space environment and shaping a good city image which are of great significance.
Modeling Particle Transport in Astrophysical Outflows and Simulations of Associated Emissions from Hadronic Microquasar Jets
Authors: Papadopoulos D. A. , Kosmas O. T. , Ganatsios S.
Published: February 2022

In this work, after improving the formulation of the model on particle transport within astrophysical plasma outflows and constructing the appropriate algorithms, we test the reliability and effectiveness of our method through numerical simulations on well-studied galactic microquasars as the SS 433 and the Cyg X-1 systems. Then, we concentrate on predictions of the associated emissions, focusing on detectable high-energy neutrinos and

γ

-rays originated from the extragalactic M33 X-7 system, which is an X-ray binary discovered in 2006, located in the neighboring galaxy Messier 33, and has not yet been modeled in detail. The particle and radiation energy distributions, produced from magnetized hadronic astrophysical jets in the context of our method, are assumed to originate from decay and scattering processes taking place among the secondary particles created when hot (relativistic) protons of the jet scatter on thermal (cold) ones (p-p interaction mechanism inside the jet). These distributions are computed by solving the system of coupled integrodifferential transport equations of multiparticle processes (reactions chain) following the inelastic proton-proton (p-p) collisions. For the detection of such high-energy neutrinos as well as multiwavelength (radio, X-ray, and gamma-ray) emissions, extremely sensitive space telescopes and other

γ

-ray and neutrino detection instruments are in operation or have been designed like the CTA, IceCube, ANTARES, KM3NeT, and IceCube-Gen-2.
MPO/HOCl Facilitates Apoptosis and Ferroptosis in the SOD1G93A Motor Neuron of Amyotrophic Lateral Sclerosis
Authors: Peng Jialing , Pan Jingrui , Mo Jingjing , Peng Ying
Published: February 2022

Background. Oxidative stress and reactive oxygen species (ROS) are important in the pathogenesis of amyotrophic lateral sclerosis (ALS). Hypochlorous acid (HOCl) is a powerful oxidant of the reactive oxygen species (ROS) family. HOCl’s role in the progress of ALS remains unclear due to the lack of an effective HOCl detection method. Cumulative evidence supports oxidative damage incurred by mutant hSOD1 contributing to motor neuron death; however, whether HOCl as well as its catalytic enzyme myeloperoxidase (MPO) function in the cell death of SOD1G93A ALS remains elusive. Methods. The hSOD1WT and hSOD1G93A NSC-34 cell and SOD1G93A ALS mouse models were employed. With a novel fluorescent HOCl probe, HKOCl-3, we detected the expressions of HOCl and its catalytic enzyme, MPO, in the above models in vitro and in vivo. The regulation of MPO/HOCl by hSOD1G93A mutation and cell deaths by MPO/HOCl were also assayed, including apoptosis, ferroptosis, and autophagy. Results. Our results showed that hSOD1G93A mutation promoted the activation of the MPO/HOCl pathway in SOD1G93A ALS cell models. The activation of MPO/HOCl pathways facilitated apoptosis and ferroptosis through increasing the Bax/Bcl-2 ratio and expression of caspase-3 or inhibiting the expressions of GPX4 and NQO1 and thus leading to irreversible lipid peroxidation. Overexpressed FSP1, a glutathione-independent suppressor, could ameliorate ferroptosis. In vivo, we demonstrated that the activation of the MPO/HOCl pathway occurred differently in motor neurons of the motor cortices, brain stems, and spinal cords in male and female SOD1G93A transgenic mice. In addition, inhibiting MPO improved the motor performance of SOD1G93A transgenic mice, as demonstrated by the rotarod test. Conclusions. We concluded that aggregation of mutant hSOD1 proteins contributed to activation of the MPO/HOCl pathway, triggering apoptosis and ferroptosis in motor neuronal deaths and exerting impaired motor performance.
Artificial Intelligence-Based Framework for Scheduling Distributed Systems Using a Combination of Neural Networks and Genetic Algorithms
Authors: Pirhoseinlo Abdolreza , Osati Eraghi Nafiseh , Akbari Torkestani Javad
Published: February 2022

High-performance distributed computation has emerged as a new development in which demand for access to resources over the Internet is being delivered to distributed servers that are dynamically scalable. One of the important research issues that must be considered in order to achieve efficient performance is timing. The goal is to map tasks to the right resources and optimize one or more subgoals so that users get the most out of their resources as quickly as possible. Therefore, in this study, in order to find a suitable solution to the scheduling problem and reduce the total time of task completion, a hybrid approach is proposed by neural networks and genetic algorithms. In this hybrid algorithm, the predictive power of artificial neural networks is used to improve scheduling problem task in order to predict the time of tasks completion on resources and the meta-heuristic of genetic algorithm is used in order to find optimal resources for tasks. Experimental results show that the performance of the proposed method is improved in Makespan compared to other methods available in the journals and can adhere to the principles of service quality.
Utilization of Personal Protective Equipment and Associated Factors among Large‐Scale Factory Workers in Debre‐Berhan Town, Amhara Region, Ethiopia, 2021
Authors: Tessema Muluken , Sema Wondimu
Published: February 2022

Background. Personal protective equipment was designed to protect workers from serious workplace injuries or illnesses resulting from contact with chemical, radiological, physical, electrical, mechanical, or other workplace hazards. Use of personal protective equipment has been identified as an important hazard control strategy in work environments where it may not be practical to adopt other strategies. Objective. To determine personal protective equipment utilization and its associated factors based on health belief model among large scale factory workers in Debre‐Birhan, Ethiopia. Methods. An institution‐based cross‐sectional study was employed in Debre‐Birhan Town, North Shoa Ethiopia, from April 1 to May 1, 2021. The data were collected by using an interviewer‐administered structured questionnaire. A total of 412 samples were selected by systematic random sampling method. The data were entered to EpiData version 3.1 and analyzed by SPSS. All independent variables were fitted into the binary logistic regression model to evaluate the degree of association and variables with a p value of <0.2 that was fitted for multiple logistic regressions. Finally, variables with a p value of <0.05 was found to be statistically significant. Result. A total of 412 workers were study participants with 100% response rate. The mean age was 29 (±7.3) years. Most workers, 367 (89%) knew that PPE can prevent work‐related injury and illness. Overall, 172 (41.7%) of the workers were considered to have good personal protective equipment utilization. Perceived susceptibility (AOR = 1.2, 95%, CI (1.076–1.38)), perceived severity (AOR = 1.1, 95%, CI (1.088–1.163)), perceived self‐efficacy (AOR = 1.2, 95%, CI (1.082–1.349)), and perceived barrier (AOR = 0.87, 95%, CI (0.800–0.956)) were found to be significant predictors of good personal protective equipment utilization. Conclusion. The study revealed that good personal protective equipment utilization in large‐scale factory workers. Perceived susceptibility, perceived severity, perceived barrier, and perceived self‐efficacy were found to be predictors of PPE utilization. It is recommended that, during delivery of health education special emphasis should be given to severity, susceptibility, barrier, and self‐efficacy of occupational disease.
HBO Alleviates Neural Stem Cell Pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 Axis and Improves Neurogenesis after Oxygen Glucose Deprivation
Authors: Ye Yuqin , Feng Zhusheng , Tian Shilai , Yang Yongxiang , Jia Yibin , Wang Guanyi , Wang Jiayou , Bai Wei , Li Jinsheng , He Xiaosheng
Published: February 2022

Due to the limited neurogenesis capacity, there has been a big challenge in better recovery from neurological dysfunction caused by stroke for a long time. Neural stem cell (NSC) programmed death is one of the unfavorable factors for neural regeneration after stroke. The types of death such as apoptosis and necroptosis have been deeply investigated while the pyroptosis of NSCs is not quite understood. Although it is well accepted that hyperbaric oxygen (HBO) alleviates the oxygen-glucose deprivation (OGD) injury after stroke and reduces programmed death of NSCs, whether NSC pyroptosis is involved in this process is still unknown. Therefore, this study is aimed at studying the potential effect of HBO treatment on NSC pyroptosis following OGD exposure, as well as its influence on NSC proliferation and differentiation in vitro. The results revealed that OGD increased NOD-like receptor protein 3 (NLRP3) expression to induce the pyroptotic death of NSCs, which was rescued by HBO treatment. And the upregulated lncRNA-H19 functioned as a molecular sponge of miR-423-5p to target NLRP3 for NSC pyroptosis following OGD. Most importantly, it was confirmed that HBO exerted protection of NSCs against pyroptosis by inhibiting lncRNA-H19/miR-423-5p/NLRP3 axis. Moreover, HBO restraint of lncRNA-H19-associated pyroptosis benefited the proliferation and neuronal differentiation of NSCs. It was concluded that HBO attenuated NSC pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 axis and enhanced neurogenesis following OGD. The findings provide new insight into NSC programmed death and enlighten therapeutic strategy after stroke.