bluuebunny/crossref_metadata_2025 huggingface dataset:
Prolactin-sensitive olfactory sensory neurons regulate male preference in female mice by modulating responses to chemosensory cues
Authors: Aoki Mari , Gamayun Igor , Wyatt Amanda , Grünewald Ramona , Simon-Thomas Martin , Philipp Stephan E. , Hummel Oliver , Wagenpfeil Stefan , Kattler Kathrin , Gasparoni Gilles , Walter Jörn , Qiao Sen , Grattan David R. , Boehm Ulrich
Published: October 2021

Prolactin modulates the detection of olfactory signals in female mice to enhance preference toward males.
OncogenicRASinstructs morphological transformation of human epithelia via differential tissue mechanics
Authors: Nyga Agata , Muñoz Jose J. , Dercksen Suze , Fornabaio Giulia , Uroz Marina , Trepat Xavier , Baum Buzz , Matthews Helen K. , Conte Vito
Published: October 2021

UniformRASactivation in an epithelium induces a 2D-to-3D transformation through induction of mechanical instability.
Biodiversity has a positive but saturating effect on imperiled coral reefs
Authors: Clements Cody S. , Hay Mark E.
Published: October 2021

Coral diversity positively affects corals, but these benefits have limits and are threatened by ongoing species loss.
The expansion of human T-bet
high
CD21
low
B cells is T cell dependent
Authors: Keller Baerbel , Strohmeier Valentina , Harder Ina , Unger Susanne , Payne Kathryn J. , Andrieux Geoffroy , Boerries Melanie , Felixberger Peter Tobias , Landry Jonathan J. M. , Nieters Alexandra , Rensing-Ehl Anne , Salzer Ulrich , Frede Natalie , Usadel Susanne , Elling Roland , Speckmann Carsten , Hainmann Ina , Ralph Elizabeth , Gilmour Kimberly , Wentink Marjolein W. J. , van der Burg Mirjam , Kuehn Hye Sun , Rosenzweig Sergio D. , Kölsch Uwe , von Bernuth Horst , Kaiser-Labusch Petra , Gothe Florian , Hambleton Sophie , Vlagea Alexandru Daniel , Garcia Garcia Ana , Alsina Laia , Markelj Gašper , Avcin Tadej , Vasconcelos Julia , Guedes Margarida , Ding Jing-Ya , Ku Cheng-Lung , Shadur Bella , Avery Danielle T. , Venhoff Nils , Thiel Jens , Becker Heiko , Erazo-Borrás Lucía , Trujillo-Vargas Claudia Milena , Franco José Luis , Fieschi Claire , Okada Satoshi , Gray Paul E. , Uzel Gulbu , Casanova Jean-Laurent , Fliegauf Manfred , Grimbacher Bodo , Eibel Hermann , Ehl Stephan , Voll Reinhard E. , Rizzi Marta , Stepensky Polina , Benes Vladimir , Ma Cindy S. , Bossen Claudia , Tangye Stuart G. , Warnatz Klaus
Published: October 2021

T cell–derived IFNγ and CD40L/IL-21R signals are crucial for the differentiation of human T-bet
high
CD21
low
B cells.
Vital signal sensing and manipulation of a microscale organ with a multifunctional soft gripper
Authors: Roh Yeonwook , Kim Minho , Won Sang Min , Lim Daseul , Hong Insic , Lee Seunggon , Kim Taewi , Kim Changhwan , Lee Doohoe , Im Sunghoon , Lee Gunhee , Kim Dongjin , Shin Dongwook , Gong Dohyeon , Kim Baekgyeom , Kim Seongyeon , Kim Sungyeong , Kim Hyun Kuk , Koo Bon-Kwon , Seo Sungchul , Koh Je-Sung , Kang Daeshik , Han Seungyong
Published: October 2021

A millimeter-scale multifunctional soft gripper provides mechanical and thermal stimulation as well as biosignal sensing.
Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice
Authors: Kalia Vandana , Yuzefpolskiy Yevgeniy , Vegaraju Adithya , Xiao Hanxi , Baumann Florian , Jatav Shashank , Church Candice , Prlic Martin , Jha Abhishek , Nghiem Paul , Riddell Stanley , Sarkar Surojit
Published: October 2021

PD-1 signals promote development of long-lived quiescent memory CD8 T cells by regulating the balance of glycolysis and fatty acid oxidation.
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors
Authors: Bellail Anita C. , Jin Hong Ri , Lo Ho-Yin , Jung Sung Han , Hamdouchi Chafiq , Kim Daeho , Higgins Ryan K. , Blanck Maximilian , le Sage Carlos , Cross Benedict C.S. , Li Jing , Mosley Amber L. , Wijeratne Aruna B. , Jiang Wen , Ghosh Manali , Zhao Yin Quan , Hauck Paula M. , Shekhar Anantha , Hao Chunhai
Published: October 2021

Small-molecule degraders of SUMO1 induce its ubiquitination and degradation through binding of CAPRIN1 in tumor cells in vitro and in vivo.
Prevalence and Whole-Genome Sequence-Based Analysis of Shiga Toxin-Producing Escherichia coli Isolates from the Recto-Anal Junction of Slaughter-Age Irish Sheep
Authors: McCarthy Siobhán C. , Macori Guerrino , Duggan Gina , Burgess Catherine M. , Fanning Séamus , Duffy Geraldine
Published: October 2021

Shiga toxin-producing
Escherichia coli
(STEC) bacteria are foodborne, zoonotic pathogens of significant public health concern. All STEC organisms harbor
stx
, a critical virulence determinant, but it is not expressed in most serotypes.
The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation
Authors: Shi Junchao , Li Zi , Xu Rongyi , Zhang Jing , Zhou Qianyu , Gao Rui , Lu Huijun , Lan Yungang , Zhao Kui , He Hongbin , Gao Feng , He Wenqi
Published: October 2021

Coronavirus diseases are caused by different coronaviruses of importance in humans and animals, and specific treatments are extremely limited. ERS, which can activate the UPR to modulate viral replication and the host innate response, is a frequent occurrence in coronavirus-infected cells.
RETRACTED: Melanin Produced by
Bordetella parapertussis
Confers a Survival Advantage to the Bacterium during Host Infection
Authors: Hiramatsu Yukihiro , Nishida Takashi , Nugraha Dendi Krisna , Sugihara Fuminori , Horiguchi Yasuhiko
Published: October 2021

In addition to the Gram-negative bacterium
Bordetella pertussis
, the etiological agent of pertussis,
Bordetella parapertussis
also causes respiratory infection in humans, with a mild pertussis-like disease. These bacteria are genetically closely related and share many virulence factors, including adhesins and toxins.
Ubericin K, a New Pore-Forming Bacteriocin Targeting mannose-PTS
Authors: Oftedal Thomas F. , Ovchinnikov Kirill V. , Hestad Kai A. , Goldbeck Oliver , Porcellato Davide , Narvhus Judith , Riedel Christian U. , Kjos Morten , Diep Dzung B.
Published: October 2021

Bacterial infections in dairy cows are a major burden to farmers worldwide because infected cows require expensive treatments and produce less milk. Today, infected cows are treated with antibiotics, a practice that is becoming less effective due to antibiotic resistance.
Routine, Cost-Effective SARS-CoV-2 Surveillance Testing Using Pooled Saliva Limits Viral Spread on a Residential College Campus
Authors: Vander Schaaf Nicole A. , Fund Anthony J. , Munnich Brianna V. , Zastrow Alexi L. , Fund Erin E. , Senti Tanner L. , Lynn Abigail F. , Kane Jonathon J. , Love Jennifer L. , Long Gregory J. , Troendle Nicholas J. , Sharda Daniel R.
Published: October 2021

This study highlights the utility of routine testing for SARS-CoV-2 using pooled saliva while maintaining high sensitivity of detection (under 2,500 copies/ml) and rapid turnaround of high volume (up to 930 samples in 8 h by two technicians and one quantitative PCR [qPCR] machine). This pooled approach allowed us to test all residential students 1 to 2 times per week on our college campus during the spring of 2021 and flagged 83% of our semester positives.
The Bacterial Life Cycle in Textiles is Governed by Fiber Hydrophobicity
Authors: Møllebjerg Andreas , Palmén Lorena Gonzales , Gori Klaus , Meyer Rikke Louise
Published: October 2021

During sweating, bacteria from the skin enter the worn textile along with the sweat. Once inside the clothes, the bacteria produce sweat malodor and form colonies that are extremely hard to remove by washing.
Supplemental Material: Lithium isotopic composition of soil pore water: Responses to evapotranspiration
Authors: Xu Zhewen , Li Gaojun , al. et
Published: October 2021

Data table and supplemental methods.
Use of pacemaker in GBS dysautonomia
Authors: Abbas Zaira , Sardar Zomer
Published: October 2021

Autonomic dysfunction in Guillain-Barrè syndrome (GBS) involves labile hypotension, hypertension, resting tachycardia and sweating. While autonomic involvement affects 66% of patients with GBS, the changes are usually transient and reversible. We hereby delineate a case of a female who presented to our medical centre with flaccid, painless progressive quadriparesis with features of dysautonomia. She had resting tachycardia, was tachypneic with reduced chest expansion and required immediate invasive mechanical ventilation. After pertinent laboratory evaluation, nerve conduction studies were promptly performed at the bedside and findings were concordant with acquired acute inflammatory demyelinating polyneuropathy. The diagnosis of GBS was made on the standard set of investigations and plasmapheresis was initiated on the same day. Her intensive care unit stay was complicated by the multiple episodes of asystole. Even though a temporary transvenous pacemaker was inserted, she, unfortunately, succumbed to a sudden episode of asystole. This paper illustrates that GBS-associated autonomic dysfunction can be severe and close cardiac monitoring is imperative in these patients.
CoronaCare study protocol: an ethnographic study of the risks to and potential for social health during the COVID-19 pandemic
Authors: Paul Joshua , Merz Sibille , Bergholz Andreas , König Franziska , Apfelbacher Christian , Eich-Krohm Astrid , Weigt Julia , Holmberg Christine
Published: October 2021

Introduction

German government regulations such as physical distancing and limited group numbers, designed to curb the spread of COVID-19, have had far-reaching consequences for the very foundations of social life. They have, to name only a few, transformed greetings and goodbyes, blurred private and public worlds, and complicated basic communication with mandatory mask wearing. The ethnographic study CoronaCare investigates how these sociopolitical measures affect social health, a form of health which unfolds through and across social relations. It explores how caring as a fundamental human activity and one integral to sustaining social health is impacted when in-person and person-to-person contacts are restricted and everyone is radically redefined as at risk from others and a risk to others. It explores care relationships, relationships involving the giving or receiving of care in everyday life, institutional settings such as an assisted living facility, and informal settings, such as a housing block. Inside of the pandemic, relationships are a pivotal site at which the negotiation of caring and risk is intensified and where the consequences for social health and social life more generally are pronounced.

Methods and analysis

This ethnographic project aims to understand the tensions that arise in the lives of individuals and communities living under the sociopolitical regulations and to analyse the tacit forms of practice that individuals and communities develop to uphold social health. Fueled by citizen science, the ethnography uses a variety of methods namely telephone and video interviews with 60–70 research participants, the collection of ethnographic material including video and audio diaries, storyboards, first-person camera footage, photographs and a survey to enrich the sample description based on the Copenhagen Psychosocial Questionnaire. The analysis will draw on elements of grounded theory and through the aid of the qualitative software MAXQDA it will rigorously document and explain how the social regulations are (re)shaping our ability to be cared for and to care for one another. The survey data will be analysed through the use of the quantitative software programme R.

Ethics and dissemination

The ethics committee of the Brandenburg Medical School Theodor Fontane has approved the project (E-01-20200605). The dissemination strategy includes publications in medical, sociological and research methods journals, as well as a stakeholder discussion with political and civil society leaders where the research team will present its recommendations for future pandemic preparedness.
Using the Functional Resonance Analysis Method to explore how elastic compression therapy is organised and could be improved from a multistakeholder perspective
Authors: Schreurs Rachel Hellen Petra , Joore Manuela A , ten Cate Hugo , ten Cate-Hoek Arina J
Published: October 2021

Objectives

Elastic compression stocking (ECS) therapy is an important treatment for patients with deep venous thrombosis (DVT) and chronic venous insufficiency (CVI). This study aimed to provide insight into the structure and variability of the ECS therapy process, its effects on outcomes, and to elicit improvement themes from a multiple stakeholder perspective.

Design

Thirty semi-structured interviews with professionals and patients were performed. The essential functions for the process of ECS therapy were extracted to create two work-as-done models using the Functional Resonance Analysis Method (FRAM). These findings were used to guide discussion between stakeholders to identify improvement themes.

Setting

Two regions in the Netherlands, region Limburg and region North-Holland, including an academic hospital and a general hospital and their catchment region.

Participants

The interviewees were purposely recruited and included 25 healthcare professionals (ie, general practitioners, internists, dermatologists, nurses, doctor’s assistants, occupational therapists, home care nurses and medical stocking suppliers) and 5 patients with DVT or CVI.

Results

Two FRAM models were created (one for each region). The variability of the functions and their effect on outcomes, as well as interdependencies between functions, were identified. These were presented in stakeholder meetings to identify the structure of the process and designated variable and uniform parts of the process and its outcomes. Ultimately, six improvement themes were identified: dissemination of knowledge of the entire process; optimising and standardising initial compression therapy; optimising timing to contact the medical stocking supplier (when oedema has disappeared); improving the implementation of assistive devices; harmonising follow-up duration for patients with CVI; personalising follow-up and treatment duration in patients with DVT.

Conclusions

This study provided a detailed understanding of how ECS therapy is delivered in daily practice by describing major functions and variability in performances and elicited six improvement themes from a multistakeholder perspective.
What role do patients prefer in medical decision-making?: a population-based nationwide cross-sectional study
Authors: Gregório Micaela , Teixeira Andreia , Henriques Teresa , Páscoa Rosália , Baptista Sofia , Carvalho Rosa , Martins Carlos
Published: October 2021

Objective

To assess patients’ preferred roles in healthcare-related decision-making in a representative sample of the Portuguese population.

Design

Population-based nationwide cross-sectional study.

Setting and participants

A sample of Portuguese people 20 years or older were interviewed face-to-face using a questionnaire with the Problem-Solving Decision-Making scale.

Outcomes

The primary outcome was patients’ preferred role for each vignette of the problem-solving decision-making scale. Sociodemographic factors associated with the preferred roles were the secondary outcomes.

Results

599 participants (20–99 years, 53.8% women) were interviewed. Three vignettes of the Problem-Solving Decision-Making scale were compared:morbidity,mortalityandquality of life. Most patients preferred a passive role for both the problem-solving and decision-making components of the scale, particularly for themortality vignette(66.1% in the analysis of the three vignettes), although comparatively more opted to share decision in the decision-making component. For thequality of life vignette, a higher percentage of patients wanted a shared role (44.3%) than with the other two vignettes. In the problem-solving component, preferences were significantly associated with area of residence (p<0.001) and educational level (p=0.013), while in the decision-making, component preferences were associated with age (p=0.020), educational level (p=0.015) and profession (p<0.001).

Conclusions

In this representative sample of the Portuguese mainland population, most patients preferred a practitioner-controlling role for both the problem-solving and decision-making components. In a life-threatening situation, patients were more willing to let the doctor decide. In contrast, in a less serious situation, there is a greater willingness to participate in decision-making. We have found that shared decision-making is more acceptable to better-educated patients in the problem-solving component and to people who are younger, higher educated and employed, in the decision-making component.
Effect of specialised versus generalised outpatient treatment for bipolar disorder: the CAG Bipolar trial - study protocol for a randomised controlled trial
Authors: Kessing Lars Vedel , Kyster Natacha Blauenfeldt , Bondo-Kozuch Pernille , Christensen Ellen Margrethe , Vejstrup Birgitte , Smidt Birte , Jørgensen Anne-Marie Bangsgaard , Rosenberg Raben , Mardosas Darius , Rasmussen Louise Behrend , Vinberg Maj , Hageman Ida , Faurholt-Jepsen Maria
Published: October 2021

Introduction

Despite current available treatment patients with bipolar disorder often experience relapses and decreased overall functioning. Furthermore, patients with bipolar disorder are often not treated medically or psychologically according to guidelines and recommendations. A Clinical Academic Group is a new treatment initiative bringing together clinical services, research, education and training to offer care and treatment that is based on reliable evidence backed up by research. The present Clinical Academic Group for bipolar disorder (the CAG Bipolar) randomised controlled trial (RCT) aims for the first time to investigate whether specialised outpatient treatment in CAG Bipolar versus generalised community-based treatment improves patient outcomes and clinician’s satisfaction with care in patients with bipolar disorder.

Methods and analysis

The CAG Bipolar trial is a pragmatic randomised controlled parallel-group trial undertaken in the Capital Region of Denmark covering a catchment area of 1.85 million people. Patients with bipolar disorder are invited to participate as part of their outpatient treatment in the Mental Health Services. The included patients will be randomised to (1) specialised outpatient treatment in the CAG Bipolar (intervention group) or (2) generalised community-based outpatient treatment (control group). The trial started 13 January 2020 and has currently included more than 600 patients. The outcomes are (1) psychiatric hospitalisations and cumulated number and duration of psychiatric hospitalisations (primary), and (2) self-rated depressive symptoms, self-rated manic symptoms, quality of life, perceived stress, satisfaction with care, use of medication and the clinicians’ satisfaction with their care (secondary). A total of 1000 patients with bipolar disorder will be included.

Ethics and dissemination

The CAG Bipolar RCT is funded by the Capital Region of Denmark and ethical approval has been obtained from the Regional Ethical Committee in The Capital Region of Denmark (H-19067248). Results will be published in peer-reviewed academic journals, presented at scientific meetings and disseminated to patient organisations and media outlets.

Trial registration number

NCT04229875.
Measurement of breathing in patients with post-COVID-19 using structured light plethysmography (SLP)
Authors: Alhuthail Eyas , Stockley James , Coney Andrew , Cooper Brendan
Published: October 2021

Introduction

COVID-19 pandemic has had a huge impact on global health to date, with 5.6 million cases in the UK since its emergence. The respiratory symptoms largely mimic those of pneumonia’ with symptoms ranging from mild to severe. The effects on respiratory physiology are not yet fully understood, but evidence is emerging that there is much dysfunctional breathing reported but little information on tidal ventilation from the acute phase of the infection. Structured light plethysmography (SLP) is a contactless technique of respiratory function testing that measures tidal breathing parameters by assessing thoracoabdominal displacement.

Methods

In a postdischarge clinic, SLP was performed routinely on 110 hospitalised patients recovering from COVID-19 who had been screened for respiratory symptoms to confirm any respiratory changes occurring after the disease. Patients were categorised based on their hospital treatment in (1) the intensive therapy unit (ITU) (requiring intubation) (n=65) or (2) respiratory wards only (n=45). Data from these two patient cohorts were compared with preacquired data from healthy controls (n=30).

Results

We have found a significantly increased respiratory rate (p=0.006) in ITU patients compared with the healthy cohort and also a significant decrease in the inspiratory time (p=0.01), expiratory time (p=0.005) and the total breathing cycle (p=0.008). There were no significant differences between ITU and ward patients and no significant differences in healthy compared with ward patients. We examined the variability of breathing (‘entropy’) both in terms of the breath-to-breath interval and the volume-to-volume change. The breath-to-breath interval alone was significantly lower in ITU patients compared with healthy cohorts (p=0.02).

Conclusion

Our findings suggest that abnormalities in tidal breathing can be detected in COVID-19 recovery patients, and SLP may be a promising tool in assessing the aftermath of diseases such as COVID-19, particularly if more intensive management strategies such as mechanical ventilation are required.
Transarterial embolization of dural arteriovenous fistulas of the lateral sinuses with stent-assisted sinus protection
Authors: Guédon Alexis , Elhorany Mahmoud , Labeyrie Marc-Antoine , Civelli Vittorio , Saint-Maurice Jean-Pierre , Houdart Emmanuel
Published: October 2021

Background

The balloon-assisted sinus protection technique has been described as a sinus-preserving technique during transarterial embolization (TAE) of dural arteriovenous fistulas (DAVFs). However, some serious complications of this technique have been documented.

Objective

To describe our preliminary experience with a new technique called stent-assisted sinus protection (SSP).

Methods

We performed a retrospective analysis of seven consecutive patients with type I or IIa DAVFs of the lateral sinus treated by TAE with a closed-cell stent temporarily deployed in the sinus.

Results

Of the seven patients, four had type I DAVF, and three had type IIa DAVF. The patency of all involved sinuses and their tributaries (including the inferior anastomotic vein and the superior petrosal sinus) was preserved. At the end of the procedure, all stents were successfully retrieved with embolic particles trapped in their meshes. No procedural complications were noted. Clinical follow-up was satisfactory, with complete resolution or significant reduction of pulsatile tinnitus.

Conclusions

SSP appears to be feasible and probably safe. However, larger studies are needed to confirm these preliminary results.
New static cylindrical symmetric solutions in GR for unfamiliar EoS parameter values via Noether symmetry
Authors: Öz Işıl Başaran , Bamba Kazuharu
Published: October 2021

The solutions for the field equations of f(R) gravity are investigated in static cylindrically symmetric space-time. Conserved quantities of the system, as well as unknown functions, can be determined with the help of the Noether symmetry method. In this article, some unknown values of the equations of state parameter (EoS) have emerged as a result of the constraints obtained by analyzing the Noether symmetry equations for the $$f(R)=f_0 R$$

f

(
R
)

=

f
0

R

case. Consequently, several new exact solutions have been found for cases of General Relativity in static cylindrically symmetrical space-time for the non-dust matter.
Irreducible representations of simple Lie algebras by differential operators
Authors: Morozov A. , Reva M. , Tselousov N. , Zenkevich Y.
Published: October 2021

We describe a systematic method to construct arbitrary highest-weight modules, including arbitrary finite-dimensional representations, for any finite dimensional simple Lie algebra $${\mathfrak {g}}$$
g
. The Lie algebra generators are represented as first order differential operators in $$\frac{1}{2} \left( \dim {\mathfrak {g}} - \text {rank} \, {\mathfrak {g}}\right) $$

1
2

dim
g
-
rank

g

variables. All rising generators $$\mathbf{e}$$
e
are universal in the sense that they do not depend on representation, the weights enter (in a very simple way) only in the expressions for the lowering operators $$\mathbf{f}$$
f
. We present explicit formulas of this kind for the simple root generators of all classical Lie algebras.
Maxwell-modified metric affine gravity
Authors: Cebecioğlu Oktay , Kibaroğlu Salih
Published: October 2021

We present a gauge formulation of the special affine algebra extended to include an antisymmetric tensorial generator belonging to the tensor representation of the special linear group. We then obtain a Maxwell modified metric affine gravity action with a cosmological constant term. We find the field equations of the theory and show that the theory reduces to an Einstein-like equation for metric affine gravity with the source added to the gravity equations with cosmological constant $$\mu $$
μ
contains linear contributions from the new gauge fields. The reduction of the Maxwell metric affine gravity to Riemann–Cartan one is discussed and the shear curvature tensor corresponding to the symmetric part of the special linear connection is identified with the dark energy. Furthermore, the new gauge fields are interpreted as geometrical inflaton vector fields which drive accelerated expansion.
A systems-level analysis of bile acids effects on rat colon epithelial cells
Authors: Yde Jonathan , Wu Qi , Borg Johan F. , Fenton Robert A. , Moeller Hanne B.
Published: October 2021

Feeding rats with a bile acid caused changes in fecal output, underlining this bile acid diarrhea model’s usefulness. Colonic epithelial expression of genes associated with facilitated transport of bile acids was altered during bile acid feeding. The study raises the possibility of regulated colonic transepithelial transport of bile acids in response to luminal bile acids. In addition, this study provides annotated rat colonic epithelial cell transcriptome and proteome with response to bile acid feeding.
World Prematurity Day: it takes an NIH village to prevent preterm birth and improve treatments for preterm infants
Authors: Bremer Andrew A. , Grewal Jagteshwar , Hazra Rohan , Romero Roberto , Bianchi Diana W.
Published: October 2021

Prematurity remains a major cause of morbidity and mortality. Research to prevent preterm birth and improve treatments for preterm infants involves both intramural and extramural research, not just at the National Institute of Child Health and Human Development, but across many institutes and centers at the National Institutes of Health.
Brachial and carotid hemodynamic response to hot water immersion in men and women
Authors: Larson Emily A. , Ely Brett R. , Brunt Vienna E. , Francisco Michael A. , Harris Sarianne M. , Halliwill John R. , Minson Christopher T.
Published: October 2021

This study sought to compare the brachial and carotid hemodynamic response to hot water immersion (HWI) between healthy young men and women. Ten women (W) and 11 men (M) (24 ± 4 yr) completed a 60-min HWI session immersed to the level of the sternum in 40°C water. Brachial and carotid artery hemodynamics (Doppler ultrasound) were measured at baseline (seated rest) and every 15 min throughout HWI. Within the brachial artery, total shear rate was elevated to a greater extent in women [+479 (+364, +594) s−1] than in men [+292 (+222, +361) s−1] during HWI ( P = 0.005). As shear rate is inversely proportional to blood vessel diameter and directly proportional to blood flow velocity, the sex difference in brachial shear response to HWI was the result of a smaller brachial diameter among women at baseline ( P < 0.0001) and throughout HWI (main effect of sex, P < 0.0001) and a greater increase in brachial velocity seen in women [+48 (+36, +61) cm/s] compared with men [+35 (+27, +43) cm/s] with HWI ( P = 0.047) which allowed for a similar increase in brachial blood flow between sexes [M: +369 (+287, +451) mL/min, W: +364 (+243, +486) mL/min, P = 0.943]. In contrast, no differences were seen between sexes in carotid total shear rate, flow, velocity, or diameter at baseline or throughout HWI. These data indicate the presence of an artery-specific sex difference in the hemodynamic response to a single bout of HWI.
The role of eye movements, attention, and hand movements on age-related differences in pegboard tests
Authors: Heintz Walters Brittany , Huddleston Wendy E. , O’Connor Kristian , Wang Jinsung , Hoeger Bement Marie , Keenan Kevin G.
Published: October 2021

This eye tracking study contributes novel findings of age-associated changes in eye movements during the commonly used pegboard tests of manual dexterity, including a greater number of corrective saccades and lesser time gazing at the pegboard holes in older compared with young adults. An association between attentional deficits and dexterity impairments in older adults is also highlighted. Results shed light on potential mechanisms underlying well-documented motor deficits in older adults.
Transcriptome analysis reveals disruption of circadian rhythms in late gestation dairy cows may increase risk for fatty liver and reduced mammary remodeling
Authors: Casey Theresa , Suarez-Trujillo Aridany M. , McCabe Conor , Beckett Linda , Klopp Rebecca , Brito Luiz , Rocha Malacco Victor Marco , Hilger Susan , Donkin Shawn S. , Boerman Jacquelyn , Plaut Karen
Published: October 2021

Circadian disruption increased insulin resistance and decreased mammary development in late gestation, nonlactating (dry) cows. The objective was to measure the effect of circadian disruption on transcriptomes of the liver and mammary gland. At 35 days before expected calving (BEC), multiparous dry cows were assigned to either control (CON) or phase-shifted treatments (PS). CON was exposed to 16-h light and 8-h dark. PS was exposed to 16-h light to 8-h dark, but phase of the light-dark cycle was shifted 6 h every 3 days. On day 21 BEC, liver and mammary were biopsied. RNA was isolated ( n = 6 CON, n = 6 PS per tissue), and libraries were prepared and sequenced using paired-end reads. Reads mapping to bovine genome averaged 27 ± 2 million and aligned to 14,222 protein-coding genes in liver and 15,480 in mammary analysis. In the liver, 834 genes, and in the mammary gland, 862 genes were different (nominal P < 0.05) between PS and CON. In the liver, genes upregulated in PS functioned in cholesterol biosynthesis, endoplasmic reticulum stress, wound healing, and inflammation. Genes downregulated in liver function in cholesterol efflux. In the mammary gland, genes upregulated functioned in mRNA processing and transcription and downregulated genes encoded extracellular matrix proteins and proteases, cathepsins and lysosomal proteases, lipid transporters, and regulated oxidative phosphorylation. Increased cholesterol synthesis and decreased efflux suggest that circadian disruption potentially increases the risk of fatty liver in cows. Decreased remodeling and lipid transport in mammary may decrease milk production capacity during lactation.
Autonomous Mobile Learning Model of Cloud Education Based on Intelligent Algorithm of Wireless Network Communication
Authors: Chen Lin , Zhu Weiping
Published: October 2021

The rapid development of a new generation of information technology and its widespread application in colleges and universities have promoted profound changes in campus informatization. On the one hand, wireless campus networks as the main infrastructure of digital campuses are gradually popularized in domestic colleges and universities, expanding the campus information network coverage. This article is aimed at studying the addition of intelligent algorithms to wireless network communications to optimize and build autonomous mobile learning for cloud education. In order for children to communicate with teachers face to face, no matter where they are, this article proposes how to reduce the energy loss in wireless communication and find the best intelligent algorithm to realize the cloud education mobile learning platform. Experimental results show that the transmission delay of the wireless communication system of this method is significantly shorter than that of the other two methods, close to 5%, which speeds up the data transmission speed of the wireless communication system. It can be implemented under time‐sensitive conditions and has high practical application value. The wireless network communication system of this method has a low packet loss rate and less wireless network data transmission errors, which is nearly 10% lower than the other two methods, thereby improving the data transmission power of the wireless communication network.
Observation on the Effect of Bone Grafting Alone and Guided Tissue Regeneration Combined with Bone Grafting to Repair Periodontal Intraosseous Defects
Authors: Yuan Yongping , Zhao Jiajia , He Nv
Published: October 2021

Objective. To investigate the curative effect of guided tissue regeneration (GTR) combined with bone grafting and improve the aesthetic appearance of patients’ gingiva. Methods. A total of 86 patients with periodontal intraosseous defects were selected from February 2019 to February 2021. All the patients were divided into a control group and an observation group according to the random number table, with 43 patients in each group. Bone grafting was performed in the control group, while GTR was additionally used in the observation group on the basis of the control group. The surgical data and follow-up data were collected and organized. The alveolar bone mineral density, the change in the height of the bone defect, plaque index (PLI), sulcus hemorrhage index (SBI), PD, gingival recession (GR), clinical attachment loss (CAL), and other relevant data of the two groups in 6 months before and after surgery were compared. Six months after surgery, the cosmetic morphology of the patient's gums in the soft tissues around her teeth was evaluated. Results. Six months after surgery, the alveolar bone density of patients in two groups increased compared with that before surgery, and the height of the bone defect decreased compared with that before surgery. The alveolar bone density of the observation group was higher than that of the control group, and the height of the bone defect was lower than that of the control group (

P
<
0.05

). Six months after surgery, the PLI, SBI, PD, and CAL of patients in both groups were lower than those before surgery, while the GR was higher than that before surgery. PD and CAL values in the observation group were lower than those in the control group, and GR was higher than that in the control group (

P
<
0.05

). Six months after surgery, there was no significant difference in PLI and SBI scores between the two groups (

P
<
0.05

). Six months after surgery, the gingival cosmetic scores of the two groups of patients were higher than those before surgery. The observation group was higher than the control group (

P
<
0.05

). Conclusion. GTR combined with bone grafting has a good effect in the repair of periodontal intraosseous defects and can effectively promote the reconstruction and recovery of periodontal intraosseous defects in patients. At the same time, it can significantly improve the aesthetic appearance of patients’ gums, with good clinical application value.
The Pattern of Cervical Cancer according to HIV Status in Yaoundé, Cameroon
Authors: Tebeu Pierre-Marie , Ngou-Mve-Ngou Jean Pierre , Zingué Laure Leka , Antaon Jesse Saint Saba , Okobalemba Atenguena Etienne , Dohbit Julius Sama
Published: October 2021

Objective. To analyze the epidemiological aspects of invasive cervical cancer according to HIV status. Methods. This was an historical cohort study from January 2010 to April 2017 in three hospitals at the Yaoundé city Capital, Cameroon, after the National Ethics Committee’ approval. We included invasive cervical cancers with documented HIV status. Odds ratios and 95% confidence interval were calculated to assess the association between the different variables and HIV status. Survival was analyzed using the Kaplan–Meier. The level of significance was set up at <5%. Results. Among the overall 213 cervical cancer patients, 56 were HIV+ (24.67%). Factors associated with positive HIV status were age below 40 (OR: 2.03 (1.38–2.67)), celibacy (OR: 2.88 (1.58–4.17)), nonmenopausal status (OR: 2.56 (1.36–3.75)), low parity, primiparity (OR: 2.59 (1.43–3.74)), and for parity with 2–4 children (OR: 2.24 (1.35–3.12)). Concerning the HIV+ patients, tumor was diagnosed late (stages III-IV) (OR: 2.70 (1.43–5.08)), undifferentiated (grade III) (OR: 7.69 (5.80–9.57)), with low median survival (9.83 months vs. 20.10 months). Conclusion. HIV is frequent among cervical cancer patients. In the HIV+ patients, the diagnosis was made at the advanced stage, cells were poorly differentiated, and the prognosis was worse.
Rehabilitation of Maxillary Defect Using Zygomatic Implant Retained Obturator
Authors: Ayinala Mounika , Shetty Gautam
Published: October 2021

Tumors involving the hard palate, maxillary sinus, or nasal cavity require maxillectomy based on the extent of the lesion. Lack of these boundaries affects the speech, esthetics, and masticatory function. Prosthetic rehabilitation of these defects can be done utilizing zygomatic implants. This present case describes the use of a zygomatic implant to retain a maxillary obturator in a 22-year-old male patient following partial maxillectomy (Brown’s Class 2b) due to odontogenic myxoma. A surgical obturator was secured in position subsequent to the implant placement. Following the healing period, an interim obturator using heat cure acrylic was fabricated. Mechanical retention for the definitive obturator was obtained through the ball attachment suspended from the multiunit abutment of the zygomatic implant. The case was followed up closely for a year to evaluate the function of the prosthesis. The prosthetic rehabilitation not only promoted esthetics and function but also improved the patient’s quality of life.
Investigation of Mechanical and Durability Properties of Concrete Mixed with Water Exposed to a Magnetic Field
Authors: Dharmaraj R. , Arunvivek G. K. , Karthick Alagar , Mohanavel V. , Perumal Bhagavathi , Rajkumar S.
Published: October 2021

Water is a crucial element in the concrete mix and is alone responsible for concrete work ability and cement hydration. The massive quantity of potable water consumed during the production of concrete is a concern. In general, fresh and hard concrete qualities are most influenced by the quantity and water quality. The use of magnetic water in concrete gives many benefits when it comes to increasing its properties. A substantial quantity of water can be saved by substituting potable water with magnetized water in concrete. In this study, the effects of magnetized water on the concrete′s mechanical and durability properties were tested. Four different combinations were made using potable water and magnetic water. Mechanical properties including compression, flexural, tensile strength, and SEM analysis were evaluated. Water absorption, acid resistance, and corrosion resistance were all tested as part of the durability tests. According to the results of the experiments, employing magnetic water for concrete preparation and curing enhanced the mechanical properties and durability. Concrete mix MMMC prepared and subjected to curing using magnetized water has a 14.86% greater compressive strength than ordinary concrete. Similarly, tensile and flexural strength of mix MMMC amplified to 14.32% and 14.02%, respectively. Besides, the consumption of chemical admixtures also considerably reduced in magnetized water imbibed concrete.
Sentiment Analysis Based on the Nursing Notes on In-Hospital 28-Day Mortality of Sepsis Patients Utilizing the MIMIC-III Database
Authors: Gao Qiaoyan , Wang Dandan , Sun Pingping , Luan Xiaorong , Wang Wenfeng
Published: October 2021

In medical visualization, nursing notes contain rich information about a patient’s pathological condition. However, they are not widely used in the prediction of clinical outcomes. With advances in the processing of natural language, information begins to be extracted from large-scale unstructured data like nursing notes. This study extracted sentiment information in nursing notes and explored its association with in-hospital 28-day mortality in sepsis patients. The data of patients and nursing notes were extracted from the MIMIC-III database. A COX proportional hazard model was used to analyze the relationship between sentiment scores in nursing notes and in-hospital 28-day mortality. Based on the COX model, the individual prognostic index (PI) was calculated, and then, survival was analyzed. Among eligible 1851 sepsis patients, 580 cases suffered from in-hospital 28-day mortality (dead group), while 1271 survived (survived group). Significant differences were shown between two groups in sentiment polarity, Simplified Acute Physiology Score II (SAPS-II) score, age, and intensive care unit (ICU) type (all

P
<
0.001

). Multivariate COX analysis exhibited that sentiment polarity (HR: 0.499, 95% CI: 0.409-0.610,

P
<
0.001

) and sentiment subjectivity (HR: 0.710, 95% CI: 0.559-0.902,

P
=
0.005

) were inversely associated with in-hospital 28-day mortality, while the SAPS-II score (HR: 1.034, 95% CI: 1.029-1.040,

P
<
0.001

) was positively correlated with in-hospital 28-day mortality. The median death time of patients with

PI
≥
0.561

was significantly earlier than that of patients with

PI
<
0.561

(13.5 vs. 49.8 days,

P
<
0.001

). In conclusion, sentiments in nursing notes are associated with the in-hospital 28-day mortality and survival of sepsis patients.
[Retracted] A Method for Short‐Term Prediction of the Metro Station’s Individual Energy Consumption Item Based on G‐ACO‐BP Model
Authors: Sha Guorong , Qian Qing
Published: October 2021

This paper proposes a new method to make short‐term predictions for the three kinds of primary energy consumption of power, lighting, and ventilated air conditioning in the metro station. First, the paper extracts the five main factors influencing metro station energy consumption through the kernel principal component analysis (KPCA). Second, improved genetic‐ant colony optimization (G‐ACO) was fused into the BP neural network to train and optimize the connection weights and thresholds between each BP neural network layer. The paper then builds a G‐ACO‐BP neural model to make short‐term predictions about different energy consumption in the metro station to predict the energy consumed by power, lighting, and ventilated air conditioning. The experimental results showed that the G‐ACO‐BP neural model could give a more accurate and effective prediction for the main energy consumption in a metro station.
Prognostic Value of BIM Deletion in EGFR‐Mutant NSCLC Patients Treated with EGFR‐TKIs: A Meta‐Analysis
Authors: Lv Fangfang , Sun Liang , Yang Qiuping , Pan Zheng , Zhang Yuhua
Published: October 2021

Background. Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) is inevitable in EGFR‐mutant non‐small‐cell lung cancer (NSCLC) patients. A germline 2903 bp deletion polymorphism of Bcl‐2‐like protein 11 (BIM) causes reduced expression of proapoptotic BH3‐only BIM protein and blocks TKI‐induced apoptosis of tumor cells. Yet the association between the deletion polymorphism and response to EGFR‐TKI treatment remains inconsistent among clinical observations. Thus, we performed the present meta‐analysis. Methods. Eligible studies were identified by searching PubMed, Embase, and ClinicalTrials.gov databases prior to March 31, 2021. Hazard ratios (HRs) and 95% confidence intervals (CIs) of progression‐free survival (PFS) and overall survival (OS) and odds ratios (ORs) and 95% CIs of objective response rate (ORR) and disease control rate (DCR) were calculated by using a random effects model. Sensitivity, metaregression, and publication bias analyses were also performed. Results. A total of 20 datasets (3003 EGFR‐mutant NSCLC patients receiving EGFR‐TKIs from 18 studies) were included. There were 475 (15.8%) patients having the 2903‐bp intron deletion of BIM and 2528 (84.2%) wild‐type patients. BIM deletion predicted significantly shorter PFS (HR = 1.35, 95% CI: 1.10‐1.64, P = 0.003) and a tendency toward an unfavorable OS (HR = 1.22, 95% CI: 0.99‐1.50, P = 0.068). Patients with deletion polymorphism had lower ORR (OR = 0.60, 95% CI: 0.42‐0.85, P = 0.004) and DCR (OR = 0.59, 95% CI: 0.38‐0.90, P = 0.014) compared with those without deletion. Conclusion. BIM deletion polymorphism may confer resistance to EGFR‐TKIs and can be used as a biomarker to predict treatment response to EGFR‐TKIs in EGFR‐mutant NSCLC patients from Asian populations.
Insight into the Significance of Hall Current and Joule Heating on the Dynamics of Darcy–Forchheimer Peristaltic Flow of Rabinowitsch Fluid
Authors: He Ji-Huan , Mostapha Doaa R.
Published: October 2021

This paper aims to present the significance of the Hall current and Joule heating impacts on a peristaltic flow of a Rabinowitsch fluid through tapered tube. The Darcy–Forchheimer scheme is used for a porous medium; a mild stenosis is considered to study the impacts of radiative heat transfer and chemical reactions. Convective conditions are postulated for heat and mass transfer. In the meantime, the slip conditions are presumed for the velocity distribution. Soret and Dufour features bring the coupled differential systems. The hypotheses of a long wavelength and low Reynolds number are employed to approximate the governing equations of motion, and finally the homotopy perturbation method is adopted for numerical study. Pumping characteristics are revealed and the trapping procedure correlated with peristaltic transport is elucidated. The present study is very important in many medical applications, such as the gastric juice motion in the small intestine and the flow of blood in arteries. The mechanism of peristaltic transport with mild stenosis has been exploited for industrial applications like sanitary fluid transport and blood pumps in heart-lung machine. The influences of various physical parameters of the problem are debated and graphically drawn across a set of figures. It is noted that the axial velocity is reduced with the increase of the Hartmann number. However, enhancing both the Rabinowitsch parameter and the Forchheimer parameter gives rise to the fluid velocity. As well, it is debated that Rabinowitsch fluid produces a cubic term of pressure gradient. Therefore, the relation between mean flow rate and the pressure rise does not stay linear. It is recognized that the temperature rises with the enhancement of both Dufour number and Soret number. Furthermore, it is illustrated that the concentration impedes with the increase of the mass transfer Biot number. Also, it is revealed that the trapped bolus contracts in size by enlarging the maximum height of stenosis.