bluuebunny/crossref_metadata_2025 huggingface dataset:
Heart rate variability during sleep in synucleinopathies: a review
Authors: Memon Adeel A. , George Ethan B. , Nazir Talha , Sunkara Yatharth , Catiul Corina , Amara Amy W.
Published: January 2024

Synucleinopathies are a group of neurodegenerative diseases characterized by abnormal accumulations of insoluble alpha-synuclein in neurons or glial cells. These consist of Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Moreover, idiopathic REM sleep behavior disorder (iRBD) is often the first manifestation of synucleinopathies, demonstrating a pathophysiological continuum. While these disorders vary in prevalence, symptom patterns, and severity, they can all include autonomic nervous system (ANS) dysfunction, which significantly reduces quality of life and worsens prognosis. Consequently, identifying abnormalities of the ANS can provide opportunities for improving quality of life through symptomatic treatments that are tailored to the individual's symptoms. An exciting development is using heart rate variability (HRV) as a non-invasive research tool for analyzing how the ANS regulates physiological processes. HRV during sleep, however, may provide a more accurate and reliable measure of ANS activity than during wakefulness, as during awake time, ANS activity is influenced by a variety of factors, including physical activity, stress, and emotions, which may mask or confound the underlying patterns of ANS activity. This review aims to provide an overview of the current knowledge regarding sleep-related HRV in synucleinopathies and to discuss contributing mechanisms. Evidence suggests that iRBD, PD, and MSA are associated with nocturnal ANS dysfunction. Further, comparative studies indicate that the presence of RBD could exacerbate this abnormality. In contrast, no studies have been conducted in patients with DLB. Overall, this review provides new insight into the complex interplay between the ANS and synucleinopathies and underscores the need for further research in this area to develop effective therapies to improve sleep and overall quality of life in patients with synucleinopathies.
Impact of smoking status on health-related quality of life (HRQoL) in cancer survivors
Authors: Nolazco José Ignacio , Rosner Bernard A. , Roebuck Emily H. , Bergerot Cristiane Decat , Rammant Elke , Iyer Geetha S. , Tang Yuzhe , Al-Faouri Ra’ad , Filipas Dejan K. , Leapman Michael S. , Mossanen Matthew , Chang Steven Lee
Published: January 2024

Introduction

The Health-Related Quality of Life (HRQoL) often declines among cancer survivors due to many factors. Some cancer patients who smoke before the cancer diagnosis continue this harmful habit, potentially contributing to a more significant decline in their HRQoL. Therefore, this study investigates the association between smoking status and HRQoL in cancer survivors.

Methods

We conducted a cross-sectional study utilizing self-reported cancer history from 39,578 participants of the Behavioral Risk Factor Surveillance System (BRFSS) database, leveraging 2016 and 2020 year questionaries. A multidimensional composite outcome was created to assess HRQoL, integrating four distinct dimensions - general health, mental health, physical health, and activity limitations. After accounting for the complex survey design, logistic regression models were used to analyze the association between smoking status and poor HRQoL, adjusting for demographic, socioeconomic, and health-related confounders.

Results

Our study found that, after adjusting for potential confounders, current smokers exhibited a significantly poorer HRQoL than never smokers (OR 1.65, 95%CI 1.40-1.93). Furthermore, former smokers showed a poorer HRQoL than never smokers; however, this association was not as strong as current smokers (OR 1.22, 95%CI 1.09-1.38).

Conclusion

Our findings highlight the adverse association of smoking with poor HRQoL in cancer survivors, underscoring the importance of healthcare professionals prioritizing smoking cessation and providing tailored interventions to support this goal.
Prognostic analysis of extrameningeal solitary fibrous tumor using the modified Demicco model: a clinicopathologic study of 111 Chinese cases
Authors: Yao Chen-chen , Zhou Jian , Li Xiao , Yang Jun , Chen Gang , Wei Jia , Fan Qin-he , Gong Qi-xing
Published: January 2024

Introduction

Solitary fibrous tumor (SFT) represents a fibroblastic neoplasm exhibiting NAB2::STAT6 gene rearrangement, displaying diverse clinical manifestations, spanning from benign to malignant. To predict prognosis, the modified (four-variable) Demicco (mDemicco) model was introduced. This investigation aims to authenticate the mDemicco risk model’s precision in Asian patients while investigating the clinicopathological and molecular factors linked to the prognosis of extrameningeal SFTs.

Methods

Clinicopathological data from 111 extrameningeal SFT cases in East China, covering the period from 2010 to 2020, were thoroughly analyzed. The tumors were classified using the mDemicco model. Immunohistochemical evaluation of P16 and P53, molecular detection of TP53 and TERT promoter mutation, and fluorescence in situ hybridization for CDKN2A gene alterations were performed. Statistical methods were utilized to assess the associations between clinicopathological or molecular factors and prognosis.

Results

Histologically, only one parameter, the mitotic count, exhibited a statistical correlation with progression-free survival (PFS) and overall survival (OS). During the Kaplan-Meier analysis, the variation in PFS among the different risk groups exhibited a notable trend towards statistical significance. Nevertheless, 3 out of 74 patients classified as low-risk SFTs and 7 out of 21 patients classified as intermediate-risk exhibited disease progression. Among the 5 patients with TP53 mutations and/or mutant-type P53 immunophenotype, 3 experienced disease progression, including 2 intermediate-risk patients. Additionally, among the 4 patients with TERT promoter mutations who were followed up, 3 showed progression, including 2 intermediate-risk patients. Moreover, it was observed that hemizygous loss of CDKN2A was detected in more than 30% of one case, yet the patient exhibited a favorable survival outcome.

Conclusion

The mDemicco risk model exhibits certain limitations when dealing with smaller tumor sizes, younger age groups, and occurrences of malignant and dedifferentiated SFTs. Furthermore, molecular factors, such as TP53 or TERT promoter mutations, may identify intermediate-risk SFTs with poorer prognoses.
The potential applications of artificially modified exosomes derived from mesenchymal stem cells in tumor therapy
Authors: Song Yilin , Song Quanlin , Hu Daosheng , Sun Binwen , Gao Mingwei , Liang Xiangnan , Qu Boxin , Suo Lida , Yin Zeli , Wang Liming
Published: January 2024

Mesenchymal stem cells (MSCs) have tumor-homing ability and play critical roles in tumor treatment, but their dual influences on tumor progression limit their therapeutic applications. Exosomes derived from MSCs (MSC-exosomes) exhibit great potential in targeted tumor treatment due to their advantages of high stability, low immunogenicity, good biocompatibility, long circulation time and homing characteristics. Furthermore, the artificial modification of MSC-exosomes could amplify their advantages and their inhibitory effect on tumors and could overcome the limit of tumor-promoting effect. In this review, we summarize the latest therapeutic strategies involving artificially modified MSC-exosomes in tumor treatment, including employing these exosomes as nanomaterials to carry noncoding RNAs or their inhibitors and anticancer drugs, and genetic engineering modification of MSC-exosomes. We also discuss the feasibility of utilizing artificially modified MSC-exosomes as an emerging cell-free method for tumor treatment and related challenges.
The importance of cancer-associated fibroblasts in targeted therapies and drug resistance in breast cancer
Authors: Zheng Jian , Hao Hua
Published: January 2024

Cancer-associated fibroblasts (CAFs) play a substantial role in the tumor microenvironment, exhibiting a strong association with the advancement of various types of cancer, including breast, pancreatic, and prostate cancer. CAFs represent the most abundant mesenchymal cell population in breast cancer. Through diverse mechanisms, including the release of cytokines and exosomes, CAFs contribute to the progression of breast cancer by influencing tumor energy metabolism, promoting angiogenesis, impairing immune cell function, and remodeling the extracellular matrix. Moreover, CAFs considerably impact the response to treatment in breast cancer. Consequently, the development of interventions targeting CAFs has emerged as a promising therapeutic approach in the management of breast cancer. This article provides an analysis of the role of CAFs in breast cancer, specifically in relation to diagnosis, treatment, drug resistance, and prognosis. The paper succinctly outlines the diverse mechanisms through which CAFs contribute to the malignant behavior of breast cancer cells, including proliferation, invasion, metastasis, and drug resistance. Furthermore, the article emphasizes the potential of CAFs as valuable tools for early diagnosis, targeted therapy, treatment resistance, and prognosis assessment in breast cancer, thereby offering novel approaches for targeted therapy and overcoming treatment resistance in this disease.
Ocular extraintestinal manifestations and treatments in patients with inflammatory bowel disease
Authors: Rodriguez Duran Mariana , O’Keefe Ghazala A. Datoo
Published: January 2024

Between 3-47% of patients with inflammatory bowel disease (IBD) have extraintestinal manifestations (EIMs), and between 1.3-86.9% of patients with IBD suffer from ocular EIMs (O-EIMs) making the eye the third most common organ affected. These O-EIMs exist among a spectrum, with a variety of types and amounts of inflammation which can lead to decreased vision, and in some cases, vision loss, without treatment. We performed a literature review concerning O-EIMs in patients who had or were later found to have a diagnosis of IBD in order to identify ocular EIMs that commonly occur with IBD and to assess which patients with IBD may be at higher risk of developing O-EIMs. We were also interested in ascertaining whether O-EIMs were more common in specific populations of people or in specific subtypes of IBD. Lastly, we explored the common treatments of O-EIMs in patients with IBD. Upon review of the literature, we found that the most common O-EIMs are episcleritis and uveitis. Anterior uveitis is more commonly seen, although, inflammation may occur in the posterior segment of the eye as well and may also manifest as retinal vasculitis. While these diagnoses are sometimes known retrospectively, most patients present with nonspecific eye complaints of which decreased vision with or without pain is the most common. Visual symptoms associated with ocular EIMs may be non-specific so physicians should have a low threshold to refer to ophthalmology for visual complaints. It is important to keep in mind that ocular EIMs can cluster with skin and joint EIMs. Screening should be prioritized for female patients with Crohn’s disease and concurrent arthritis. Treatments for O-EIMs are outlined and compared in this paper as well.
Splenogonadal fusion: a case report of three cases and a literature review
Authors: Luo Na , Xu Qitao , Wang Hao , Su Jiahong , Li Shoulin
Published: January 2024

Purpose

This case report aims to enhance the understanding of clinical physicians regarding splenogonadal fusion (SGF) and to help them consider SGF as a differential diagnosis when testicular tumors are suspected, thus avoiding unnecessary orchiectomies.

Methods

We report three cases of SGF admitted to our hospital, one of which presented as a suspected testicular tumor. We also searched the literature on scrotal masses from the last 25 years and summarize the characteristics of cases of SGF manifesting as scrotal swelling combined with our cases.

Results

After conducting a thorough search, we found a total of 24 publications relevant to this case study, which included 25 testes. All lesions were located on the left side, and the average age of those affected was 20.22 years. Seven cases were of the continuous type. Three cases presented with pain, all of which were intratesticular masses. Thirty cases had a definite onset duration, ranging from 3 weeks to 10 years. Nine patients (36%) underwent orchiectomy, and one underwent partial orchiectomy.

Conclusion

It is crucial to identify SGF in the clinic. When a patient presents with scrotal swelling, diagnosing SGF preoperatively is challenging, and it should be considered when there is a long history of a stable testicular mass. An intraoperative frozen section should be performed if a testicular tumor is suspected to avoid unnecessary orchiectomy.
Phytochemical and biological studies of Panicum antidotale aerial parts ethanol extract supported by molecular docking study
Authors: Sarwar Imtisal , Asif Muhammad , Jamshaid Talha , Saadullah Malik , Zubair Hafiz Muhammad , Saleem Mohammad , Jamshaid Usama , Youssef Fadia S. , Ashour Mohamed L. , Elhady Sameh S.
Published: January 2024

Panicum antidotale has traditionally been used as a poultice to alleviate local inflammation and painful diseases. This study aimed to evaluate the anti-inflammatory, wound-healing, analgesic, and antipyretic potential of its ethanol extract (PAAPEE) in vivo for the first time. In vitro antioxidant assays of Panicum antidotale using a 2,2-diphenyl-1-picrylhydrazyl assay revealed that it showed IC50 of 62.50 ± 6.85 μg/mL in contrast to standard, ascorbic acid, that showed IC50 of 85.51 ± 0.38 μg/mL. Administration of PAAPEE at a dose of 500 mg/kg (PAAPEE-500) displayed 78.44% and 75.13% inhibition of paw edema in carrageenen and histamine-induced edema models. respectively, 6 h post-treatment compared to that of the untreated group. Furthermore, it showed 68.78% inhibition of Freund’s complete adjuvant-induced edema 21 days after treatment. It reduced the animal’s rectal temperature in the yeast-induced fever model to 99.45 during the fourth h post-treatment. It significantly inhibited abnormal writhing by 44% in the acetic acid-induced pain model. PAE-500 also showed enhancement in wound closure by 72.52% with respect to that of the untreated group on the 10th day post-treatment using the excision healing of wound model. Histopathological examination of skin samples confirmed this improvement, showing enhanced tissue architecture with minimal infiltration of inflammatory cells. High-performance liquid chromatography (HPLC) of PAAPEE revealed the presence of quercetin, gallic, p-coumaric, benzoic, chlorogenic, syringic, ferulic, cinnamic, and sinapic acids. Molecular docking of 5-lipoxygenase and glycogen synthase kinase-3 β protein indicated their potential interaction within the active sites of both enzymes. Thus, P. antidotale serves as an effective natural wound-healing, anti-inflammatory, analgesic, and antipyretic agent.
Myosin Va: Capturing cAMP for synaptic plasticity
Authors: Rudolf Rüdiger
Published: January 2024

The plus-end directed actin-dependent motor protein, myosin Va, is of particular relevance for outward vesicular protein trafficking and for restraining specific cargo vesicles within the actin cortex. The latter is a preferred site of cAMP production, and the specificity of cAMP signaling is largely mediated through the formation of microdomains that spatially couple localized metabotropic receptor activity and cAMP production to selected effectors and downstream targets. This review summarizes the core literature on the role of myosin Va for the creation of such a cAMP microdomain at the mammalian nerve–muscle synapse that serves the activity-dependent recycling of nicotinic acetylcholine receptors (nAChRs)—a principal ligand-gated ion channel which is imperative for voluntary muscle contraction. It is discussed that i) the nerve–muscle synapse is a site with a unique actin-dependent microstructure, ii) myosin Va and protein kinase A regulatory subunit Iα as well as nAChR and its constitutive binding partner, rapsyn, colocalize in endocytic/recycling vesicles near the postsynaptic membrane, and iii) impairment of myosin Va or displacement of protein kinase A regulatory subunit Iα leads to the loss of nAChR stability. Regulation of this signaling process and underlying basic pieces of machinery were covered in previous articles, to which the present review refers.
Maize plant detection using UAV-based RGB imaging and YOLOv5
Authors: Lu Chenghao , Nnadozie Emmanuel , Camenzind Moritz Paul , Hu Yuncai , Yu Kang
Published: January 2024

In recent years, computer vision (CV) has made enormous progress and is providing great possibilities in analyzing images for object detection, especially with the application of machine learning (ML). Unmanned Aerial Vehicle (UAV) based high-resolution images allow to apply CV and ML methods for the detection of plants or their organs of interest. Thus, this study presents a practical workflow based on the You Only Look Once version 5 (YOLOv5) and UAV images to detect maize plants for counting their numbers in contrasting development stages, including the application of a semi-auto-labeling method based on the Segment Anything Model (SAM) to reduce the burden of labeling. Results showed that the trained model achieved a mean average precision (mAP@0.5) of 0.828 and 0.863 for the 3-leaf stage and 7-leaf stage, respectively. YOLOv5 achieved the best performance under the conditions of overgrown weeds, leaf occlusion, and blurry images, suggesting that YOLOv5 plays a practical role in obtaining excellent performance under realistic field conditions. Furthermore, introducing image-rotation augmentation and low noise weight enhanced model accuracy, with an increase of 0.024 and 0.016 mAP@0.5, respectively, compared to the original model of the 3-leaf stage. This work provides a practical reference for applying lightweight ML and deep learning methods to UAV images for automated object detection and characterization of plant growth under realistic environments.
Zero-exemplar deep continual learning for crop disease recognition: a study of total variation attention regularization in vision transformers
Authors: Wang Boyuan
Published: January 2024

With the increasing integration of AI technology in the food industry, deep learning has demonstrated its immense potential in the domain of plant disease image recognition. However, there remains a gap in research between models capable of continual learning of new diseases and addressing the inherent catastrophic forgetting issue in neural networks. This study aims to comprehensively evaluate various learning strategies based on advanced computer vision models for multi-disease continual learning tasks in food disease recognition. To cater to the benchmark dataset requirements, we collected the PlantDiseaseCL dataset, sourced from the internet, encompassing diverse crop diseases from apples, corn, and more. Utilizing the Vision Transformer (ViT) model, we established a plant disease image recognition classifier, which, in joint learning, outperformed several comparative CNN architectures in accuracy (0.9538), precision (0.9532), recall (0.9528), and F1 score (0.9560). To further harness the potential of ViT in food disease defect recognition, we introduced a mathematical paradigm for crop disease recognition continual learning. For the first time, we proposed a novel ViT-TV architecture in the multi-disease image recognition scenario, incorporating a Total Variation (TV) distance-based loss (TV-Loss) to quantify the disparity between current and previous attention distributions, fostering attention consistency and mitigating the catastrophic forgetting inherent in ViT without prior task samples. In the incremental learning of the PlantDiseaseCL dataset across 3-Steps and 5-Steps, our strategy achieved average accuracies of 0.7077 and 0.5661, respectively, surpassing all compared Zero-Exemplar Approaches like LUCIR, SI, MAS, and even outperforming exemplar-based strategies like EEIL and ICaRL. In conclusion, the ViT-TV approach offers robust support for the long-term intelligent development of the agricultural and food industry, especially showcasing significant applicability in continual learning for crop disease image recognition.
Characterization key genes of Arabidopsis seedlings in response to β-caryophyllene, eugenol using combined transcriptome and WGCN analysis
Authors: Guo Yuqi , Liu Chang , Zhang Yaran , Zheng Shuting , Cao Ping , Wang Xiaomin , Tian Zengyuan
Published: January 2024

Weeds present a significant challenge to high crop yield and quality. In our study, we investigated the phytotoxic activity of β-caryophyllene (BCP) and eugenol, which are natural allelopathic chemical compounds, on Arabidopsis seedlings. We found that these compounds inhibited the growth of Arabidopsis thaliana plants. When either BCP or eugenol was applied, it led to decrease in the content of cell wall components such as lignin, cellulose, hemicellulose, and pectin; and increase in the levels of endogenous hormones like ETH, ABA, SA, and JA in the seedlings. Through transcriptome profiling, we identified 7181 differentially expressed genes (DEGs) in the roots and shoots that were induced by BCP or eugenol. The genes involved in the synthesis of lignin, cellulose, hemicellulose, and pectin were down-regulated, whereas genes related to synthesis and signal transduction of ABA, ETH, SA, and JA were up-regulated. However, genes related to IAA synthesis and signal transduction were found to be down-regulated. Furthermore, we characterized 24 hub genes using Weighted Correlation Network Analysis (WGCNA). Among them, the identified 16 genes in response to BCP was primarily associated with hypoxia stress, while 8 genes induced by eugenol were linked to inhibition of cell division. Our results suggested that BCP and eugenol had ability to target multiple genes to inhibit growth and development of Arabidopsis plants. Therefore, they can serve as excellent candidates for natural biological herbicides.
Quality evaluation of four Ferula plants and identification of their key volatiles based on non-targeted metabolomics
Authors: Jiang Meng , Peng Mengwen , Li Yuxia , Li Guifang , Li Xiaobo , Zhuang Li
Published: January 2024

Introduction

Ferula is a traditional, edible, and important medicinal plant with high economic value. The distinction between edible and non-edible Ferula remains unclear.

Methods

In this study, headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry (HS-SPME/GC-MS) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) non-targeted metabolomics techniques were used to systematically and comprehensively analyse secondary metabolites in the leaves and roots of four species of Ferula, considering their edibility.

Results

A total of 166 leaf volatile organic compounds (VOCs) and 1,079 root metabolites were identified. Additionally, 42 potential VOCs and 62 differential root metabolites were screened to distinguish between edible and non-edible Ferula. Twelve volatile metabolites were specific to F. feurlaeoides, and eight compounds were specific to the three edible Ferula species. The results showed that compounds containing sulphur, aldehydes, and ketones, which produce pungent odours, were the primary sources of the strong odour of Ferula. The root differential metabolites include 13 categories, among which the high concentration group is organic acids, amino acids, terpenoids and fatty acids. The bioactive metabolites and VOCs in the roots exhibited species-specific characteristics. VOCs with various odors were linked to the distribution of root metabolites in both edible and non-edible Ferula plants. The screened root markers may contribute to the formation of characteristic VOCs.

Discussion

This study identified the difference in flavour between edible and non-edible Ferula plants and, for the first time, demonstrated the contribution of the efficacy of Ferula root to the unique flavour of the above-ground parts of Ferula. These results provide a theoretical basis for selecting Ferula for consumption and help evaluate the quality of different species of Ferula. Our findings may facilitate food processing and the further development of Ferula.
Dual RNA-sequencing of Fusarium head blight resistance in winter wheat
Authors: Walker Philip L. , Belmonte Mark F. , McCallum Brent D. , McCartney Curt A. , Randhawa Harpinder S. , Henriquez Maria A.
Published: January 2024

Fusarium head blight (FHB) is a devastating fungal disease responsible for significant yield losses in wheat and other cereal crops across the globe. FHB infection of wheat spikes results in grain contamination with mycotoxins, reducing both grain quality and yield. Breeding strategies have resulted in the production of FHB-resistant cultivars, however, the underlying molecular mechanisms of resistance in the majority of these cultivars are still poorly understood. To improve our understanding of FHB-resistance, we performed a transcriptomic analysis of FHB-resistant AC Emerson, FHB-moderately resistant AC Morley, and FHB-susceptible CDC Falcon in response to Fusarium graminearum. Wheat spikelets located directly below the point of inoculation were collected at 7-days post inoculation (dpi), where dual RNA-sequencing was performed to explore differential expression patterns between wheat cultivars in addition to the challenging pathogen. Differential expression analysis revealed distinct defense responses within FHB-resistant cultivars including the enrichment of physical defense through the lignin biosynthesis pathway, and DON detoxification through the activity of UDP-glycosyltransferases. Nucleotide sequence variants were also identified broadly between these cultivars with several variants being identified within differentially expressed putative defense genes. Further, F. graminearum demonstrated differential expression of mycotoxin biosynthesis pathways during infection, leading to the identification of putative pathogenicity factors.
NRAMP gene family in Kandelia obovata: genome-wide identification, expression analysis, and response to five different copper stress conditions
Authors: Hussain Quaid , Ye Ting , Shang Chenjing , Li Sihui , Khan Asadullah , Nkoh Jackson Nkoh , Mustafa Abd El-Zaher M. A. , Elshikh Mohamed S.
Published: January 2024

Natural resistance-associated macrophage proteins (NRAMPs) are a class of metal transporters found in plants that exhibit diverse functions across different species. Transporter proteins facilitate the absorption, distribution, and sequestration of metallic elements within various plant tissues. Despite the extensive identification of NRAMP family genes in various species, a full analysis of these genes in tree species is still necessary. Genome-wide identification and bioinformatics analysis were performed to understand the roles of NRAMP genes in copper (CuCl2) stress in Kandelia obovata (Ko). In Arachis hypogaea L., Populus trichocarpa, Vitis vinifera, Phaseolus vulgaris L., Camellia sinensis, Spirodela polyrhiza, Glycine max L. and Solanum lycopersicum, a genome-wide study of the NRAMP gene family was performed earlier. The domain and 3D structural variation, phylogenetic tree, chromosomal distributions, gene structure, motif analysis, subcellular localization, cis-regulatory elements, synteny and duplication analysis, and expression profiles in leaves and CuCl2 were all investigated in this research. In order to comprehend the notable functions of the NRAMP gene family in Kandelia obovata, a comprehensive investigation was conducted at the genomic level. This study successfully found five NRAMP genes, encompassing one gene pair resulting from whole-genome duplication and a gene that had undergone segmental duplication. The examination of chromosomal position revealed an unequal distribution of the KoNRAMP genes across chromosomes 1, 2, 5, 7, and 18. The KoNRAMPs can be classified into three subgroups (I, II, and SLC) based on phylogeny and synteny analyses, similar to Solanum lycopersicum. Examining cis-regulatory elements in the promoters revealed five hormone-correlated responsive elements and four stress-related responsive elements. The genomic architecture and properties of 10 highly conserved motifs are similar among members of the NRAMP gene family. The conducted investigations demonstrated that the expression levels of all five genes exhibited alterations in response to different levels of CuCl2 stress. The results of this study offer crucial insights into the roles of KoNRAMPs in the response of Kandelia obovata to CuCl2 stress.
Lobbying the executives: differences in lobbying patterns between elected politicians, partisan advisors and public servants
Authors: Cooper Christopher A. , Boucher Maxime
Published: January 2024

Research from parliamentary countries suggests that lobbyists tend to focus their attention on public office holders within the executive government more than those within the legislative branch. To date, however, research studying executive-lobbying relations tends to treat “the executive” and “lobbyists” as two homogenous groups. Yet importantly, not all executive personnel and lobbyists are the same. The executive is made-up of popularly elected politicians, partisan advisors and non-partisan bureaucrats, who vary in their skills, motivations, responsibilities and power within government. Differences also exist in the level of expertise and political representativeness between in-house and consultant lobbyists. Using longitudinal data between 2015 and 2022 from Canada's Lobbyist Registry, this article digs deeper into the executive-lobbying nexus by examining the number of contacts consultant and in-house lobbyists have with different executive personnel—ministers, partisan advisors, senior public servants and non-senior public servants. Although the data shows no meaningful variation tied to differences across partisan-political and administrative personnel within the executive, there is substantive variation in lobbying intensity between upper and lower ranked executive personnel; in-house lobbyists lobby senior political and senior administrative personnel twice as much as consultant lobbyists. These findings are consistent with theory on the expertise and representative function some lobbyists possess, more so than theory emphasizing differences between partisan-political and administrative personnel within the executive.
Youth recidivism: youth self-report matters
Authors: Holloway Evan D. , Irgens Megan , McPhee Jeanne , Folk Johanna B. , Tolou-Shams Marina
Published: January 2024

Introduction

“Recidivism” is used ubiquitously in juvenile justice research and typically describes repeat legal contact; however, researchers, policymakers, and clinicians operationalize it in various ways. Despite assuming each measure is a proxy for continued delinquent behavior leading to further legal contact, few have examined the association between youth delinquent behavior and self-reported and official records of legal contact. Furthermore, systemic bias against ethnoracial and gender minoritized youth often results in more harsh treatment by the legal system, which could influence recidivism measurement. Latent variable modeling of legal contact is understudied; thus, it is important to examine the feasibility of measuring this construct as a latent variable, including measurement invariance by gender.

Methods

Among 401 youth ages 12–18 years at first ever court contact, we examined three metrics of legal contact over a 2-year follow-up period: youth-report of arrest, caregiver-report of their adolescent’s arrest, and official records of the number of new court charges. We examined between-group differences on each metric based on gender and ethnoracial identity. We then measured: (1) the association between youths’ self-reported delinquency and each metric, (2) gender-specific associations between self-reported delinquency and each metric, and (3) gender-based measurement invariance for a latent recidivism variable using confirmatory factor analysis.

Results

Youth were consistent reporters of their own delinquent behavior and prospective legal contact measured by arrests. There were no between-group differences based on gender or ethnoracial identity for any legal contact measures. Delinquency and all legal contact variables were positively intercorrelated for the overall sample and the male subsample. For females, delinquency was not associated with caregiver-reported youth arrest or number of new charges. The latent legal contact variable had unique factor structures for male and female subsamples, suggesting no measurement invariance.

Discussion

Youth-reported delinquency at first ever legal contact was most strongly associated with youth-reported arrest during a 2-year follow-up period, followed by caregiver-reported arrest, and the number of new charges. Unique latent variable factor structures for male and female subsamples suggests the inter-relation between legal contact variables is gender-specific. Stakeholders should consider prioritizing youth-reported delinquency since it is most strongly related to prospective youth-reported arrest.
Sports fanaticism as a disease: a Corpus-based study of metaphors in Saudi newspapers
Authors: Mobarki Yahya Abdu A. , Alzahrani Fahad
Published: January 2024

Sports fanaticism seems to be a social and national concern in Saudi Arabia. This paper aims: 1) to identify the metaphorical manifestations and highlight the discursive construction of disease as associated with sports fanaticism in a corpus of Saudi newspapers articles; and 2) to seek plausible explanations for the emergence and use of disease metaphors in newspapers articles addressing sports fanaticism. King Abdulaziz City for Science and Technology Arabic Corpus (KACSTAC) served the data for the current study. The analytical procedures were informed by the discourse dynamics approach and metaphor-led discourse analysis. Findings show that sports fanaticism could be associated with the following systematic metaphors: 1) disease, in general; 2) disease causes; 3) disease symptoms; 4) disease evaluations; and 5) disease needs for medical solutions, interventions, treatments, and/or prescriptions. The discussion evokes a number of aspects: sports fanaticism emerges as a key topic; disease metaphors seem to be shaped and developed by the societal context and the nature of newspapers texts and discourse; they are enriched and influenced by the discourse situation and the needs to jointly construct and communicate intense experiences through specific evaluations and referential functions, which have a powerful resonance for the Saudi national and social levels; the use of disease metaphorical frames can structure our understanding and can simplify the concept of fanaticism.
Association between suicidal ideation and tandem repeats in contactins
Authors: Parikh Kairavi , Quintero Reis Andrea , Wendt Frank R.
Published: January 2024

Background

Death by suicide is one of the leading causes of death among adolescents. Genome-wide association studies (GWAS) have identified loci that associate with suicidal ideation and related behaviours. One such group of loci are the six contactin genes (CNTN1-6) that are critical to neurodevelopment through regulating neurite structure. Because single nucleotide polymorphisms (SNPs) detected by GWAS often map to non-coding intergenic regions, we investigated whether repetitive variants in CNTNs associated with suicidality in a young cohort aged 8 to 21. Understanding the genetic liability of suicidal thought and behavior in this age group will promote early intervention and treatment.

Methods

Genotypic and phenotypic data were obtained from the Philadelphia Neurodevelopment Cohort (PNC). Across six CNTNs, 232 short tandem repeats (STRs) were analyzed in up to 4,595 individuals of European ancestry who expressed current, previous, or no suicidal ideation. STRs were imputed into SNP arrays using a phased SNP-STR haplotype reference panel from the 1000 Genomes Project. We tested several additive and interactive models of locus-level burden (i.e., sum of STR alleles) with respect to suicidal ideation. Additive models included sex, birth year, developmental stage (“DevStage”), and the first 10 principal components of ancestry as covariates; interactive models assessed the effect of STR-by-DevStage considering all other covariates.

Results

CNTN1-[T]N interacted with DevStage to increase risk for current suicidal ideation (CNTN1-[T]N-by-DevStage; p = 0.00035). Compared to the youngest age group, the middle (OR = 1.80, p = 0.0514) and oldest (OR = 3.82, p = 0.0002) participant groups had significantly higher odds of suicidal ideation as their STR length expanded; this result was independent of polygenic scores for suicidal ideation.

Discussion

These findings highlight diversity in the genetic effects (i.e., SNP and STR) acting on suicidal thoughts and behavior and advance our understanding of suicidal ideation across childhood and adolescence.
Empowering 6G maritime communications with distributed intelligence and over-the-air model sharing
Authors: Zetas Menelaos , Spantideas Sotirios , Giannopoulos Anastasios , Nomikos Nikolaos , Trakadas Panagiotis
Published: January 2024

Introduction: Shipping and maritime transportation have gradually gained a key role in worldwide economical strategies and modern business models. The realization of Smart Shipping (SMS) powered by advanced 6G communication networks, as well as innovative Machine Learning (ML) solutions, has recently become the focal point in the maritime sector. However, conventional centralized learning schemes are unsuitable in the maritime domain, due to considerable data communication overhead, stringent energy constraints, increased transmission failures in the harsh propagation environment, as well as data privacy concerns.

Methods: To overcome these challenges, we propose the joint adoption of Federated Learning (FL) principles and the utilization of the Over-the-Air computation (AirComp) wireless transmission framework. Thus, this paper initially describes the mathematical considerations of a 6G maritime communication system, focusing on the heterogeneity of the relevant nodes and the channel models, including an Unmanned Aerial Vehicle (UAV)-aided relaying model that is usually required in maritime communications. The communication network, enhanced with the AirComp technique for efficiency purposes, forms the technical basis for the collaborative learning across multiple Internet of Maritime Things (IoMT) nodes in FL tasks. The workflow of the FL/AirComp scheme is illustrated and proposed as a communication-efficient and privacy-aware SMS framework, considering spectrum and energy efficiency aspects under a sum transmitting power constraint.

Results: Then, the performance of the proposed methodology is assessed in an important ML task, related to intelligent maritime transportation systems, namely, the prediction of the Cargo Ship Propulsion Power using real data originating from six cargo ships and utilizing long-short-term-memory (LSTM) neural networks. Upon extensive experimentation, FL showed higher prediction accuracy relative to the typical Ensemble Learning technique by a factor of 3.04. The AirComp system performance was evaluated under varying noise conditions and number of IoMT nodes, using simulation data for the channel state information by regulating the power of the transmitting IoMT entities and the scaling factor at the shore base station.

Discussion: The results clearly indicate the efficiency of the proposed FL/AirComp scheme in achieving low computation error, collaborative learning, spectrum efficiency and privacy protection in wireless maritime communications, while providing adequate accuracy levels with respect to the optimization objective.
SWI/SNF chromatin remodelers in prostate cancer progression
Authors: Ordonez-Rubiano Sandra C. , Strohmier Brayden P. , Sood Surbhi , Dykhuizen Emily C.
Published: January 2024

Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer-related deaths in men in the US. The majority of PCa cases arise in the luminal cells of the prostate and develop into adenocarcinoma. Primary PCas are heterogeneous and have alterations in a variety of tumor suppressors and oncogenes; however, the vast majority are dependent on gene expression regulation by androgen receptor (AR), making it the focus for most targeted therapy development. As the incidence of PCa cases resistant to AR-targeted therapies rises, there is renewed attention on how additional genetic and epigenetic alterations contribute to PCa progression and resistance. In this review we summarize the efforts made over the past 20 years to dissect the function of the SWI/SNF chromatin remodelers in PCa. We mainly focus on how SWI/SNF complexes regulate different aspects of AR signaling, facilitate other key drivers in PCa, promote the advancement of the disease, and regulate the tumor microenvironment.
Audiologists’ attitudes and practice toward referring for psychosocial intervention with cochlear implant patients
Authors: Warren Sarah E. , Barron Autumn L.
Published: January 2024

Background

Hearing loss is associated with a range of poor psychosocial outcomes. Cochlear implants (CI) are an available treatment option for significant hearing loss and have been linked to improved quality of life in patients. Evidence suggests that audiologists lack the skills to appropriately detect, address, and refer for psychosocial needs among patients with hearing loss. The objective of this study is to examine the attitudes and practice patterns related to psychosocial care among audiologists who work with CI users.

Methods

A cross-sectional survey was administered to clinical audiologists who work with CI recipients in the United States. The survey evaluated participants’ attitudes toward psychosocial services and factors that contribute to their abilities to address the psychosocial needs of their patients. Additionally, participants were surveyed about their practice patterns including the use of psychosocial screeners, clinical protocols regarding psychosocial care, and referral patterns for coordinated psychosocial services. Descriptive statistics were used to summarize survey responses.

Results

Sixty-eight audiologists completed the survey. Of these audiologists, a majority (73.6%) held the attitude that most or all CI patients would benefit from psychosocial intervention. Despite clinicians’ recognition of psychosocial needs in this population, over 90% of participants reported never screening for psychosocial symptoms. Additionally, a majority of respondents indicated that they seldom refer their patients for psychosocial services, with referrals occurring less than half the time (58%) or never (27%). Additionally, few audiologists reported utilizing protocols or resources for guiding psychosocial practices. Audiologists indicated that the primary factors that influence their psychosocial practices include time available to spend with the patient and their comfort level in counseling.

Conclusion

Audiologists working with CI patients recognize the potential benefit of psychosocial intervention in this population. Nevertheless, audiologists encounter barriers in clinical practice which limit their ability to identify and address the psychosocial needs of their patients. Strategies designed to enhance audiologists’ capacity to recognize the psychosocial needs of CI users, in addition to improved interprofessional practice on CI teams, implies significant opportunities to improve the provision of patient-centered hearing care.
Assessing the “virality” of a road safety communication campaign intended to change behavior: a case study in Spain
Authors: Faus Mireia , Alonso Francisco , Fernández Cesáreo , Useche Sergio A.
Published: January 2024

Introduction

The relationships between above-the-line (ATL) and below-the-line (BTL) communication and advertising strategies have been studied in many fields and procedures. Likewise, the interrelationships between both communicative typologies, when they exist, either strategically induced or spontaneously, are also known concerning their reinforcing effects. However, in the social communication field, specifically road safety communication, these interrelationships have been little studied, and few case studies have been done, particularly of those that have stood out as particularly significant.

Methods

Thus, this paper investigates the implementation process of an ATL awareness campaign of the Spanish Traffic Authority (DGT-General Directorate of Traffic) through the analysis of key digital reach indicators.

Results

Despite the foreseeable limitations of this research regarding the repercussions and positive impact on society of the DGT communication campaign, it is nevertheless a contribution of interest regarding the digital impact that has been generated in networks (BTL communication) from a DGT campaign broadcast on various media such as television, radio, posters, and social networks.

Discussion

Thus, from a methodology based on an exact delimitation (two DGT TV spots -from 2022- generating a quantitative activity on X (formally Twitter) that had never before produced DGT spots), significant conclusions and results have been reached related to issues of age groups, loyalty and distortion of messages, communication impact strategies, among others.
Recent results and future perspectives with solid targets at LUNA
Authors: Ananna Chemseddine , Barbieri Lucia , Boeltzig Axel , Campostrini Matteo , Casaburo Fausto , Ciani Giovanni Francesco , Compagnucci Alessandro , Gesuè Riccardo Maria , Marsh Jordan , Masha Eliana , Mercogliano Daniela , Rapagnani David , Robb Duncan , Sidhu Ragandeep Singh , Skowronski Jakub
Published: January 2024

The stellar evolution and chemical make-up of the Universe are determined by nuclear reactions occurring in a wide variety of stellar sites. Precise determinations of the cross sections of these reactions are crucial for the calculation of reaction rates and for the development of stellar evolution models. The Laboratory for Underground Nuclear Astrophysics (LUNA) collaboration has been at the forefront of the direct measurement of nuclear reactions at the low energies of astrophysical interest for the last 35 years. The many significant results achieved at LUNA have been made possible due to the low background conditions uniquely available thanks to its location deep underground at the Laboratori Nazionali del Gran Sasso. Another key aspect of these successes is due to the experience of the LUNA collaboration in the production and characterization of a variety of solid targets used in reaction measurements. In this review, the main production techniques of solid targets are described, as well as the common methods adopted for target degradation monitoring. We also present the results of recent measurements using these targets and the future plans of the LUNA collaboration for measurements using solid targets at the LUNA400 kV and the new Ion Beam Facility (IBF) 3.5 MV are also presented.