bluuebunny/crossref_metadata_2025 huggingface dataset:
HIV infection in adult Ugandans with new-onset type 2 diabetes: exploring its influence on the anthropometric and metabolic profile
Authors: Kibirige Davis , Sekitoleko Isaac , Owarwo Noela , Andia-Biraro Irene , Lumu William
Published: August 2023

Objective

HIV infection increases the risk of type 2 diabetes and may influence its phenotypic profile. In this study, we aimed to compare the anthropometric and metabolic characteristics of HIV-infected and uninfected adult Ugandans with new-onset type 2 diabetes to evaluate the influence of HIV infection on specific surrogate markers of adiposity, insulin resistance, and pancreatic beta-cell function.

Methods

We consecutively recruited 500 HIV-infected and uninfected adult Ugandans with new-onset type 2 diabetes (diagnosed in < 3 months) from seven tertiary hospitals over a 20-month period and compared their anthropometric and metabolic characteristics to identify any significant differences.

Results

Of the 500 participants with new-onset type 2 diabetes, 59 (11.8%) had a self-reported history of HIV infection. Compared with HIV-uninfected participants with type 2 diabetes, participants with HIV infection and type 2 diabetes had a lower median (IQR) hip circumference (97.8 [91.0-106.0] cm vs. 104.0 [96.0-112.0], p = 0.002) and visceral fat level (8 [6–11] vs. 10 [7–12], p < 0.001) assessed using bioimpedance analysis. No statistically significant difference was noted with the markers of pancreatic beta-cell function (fasting, 30-minute, and 120-minute C-peptide concentrations, oral insulinogenic index, and homeostatic model assessment 2-beta cell function) and insulin resistance (homeostatic model assessment 2-insulin resistance) between both groups.

Conclusion

In our study population, HIV infection was not associated with increased adiposity, pancreatic beta-cell function, and insulin resistance. Large prospective studies are needed to investigate the effect of HIV on the pathogenesis of type 2 diabetes in adult Ugandans.
The rates and symptoms of natural and breakthrough infection pre- and post- Covid-19 non-mRNA vaccination at various peaks amongst Iranian healthcare workers
Authors: Jamalidoust Marzieh , Eilami Owrang , Ashkan Zahra , Ziyaeyan Mazyar , Aliabadi Nasrin , Habibi Mohammad
Published: August 2023

Background/Aims

The aim of this study was to determine the rate of natural and breakthrough infection and related symptoms of Covid-19 amongst Iranian healthcare workers (HCWs) who were vaccinated by different non-mRNA-based vaccines at peak points.

Methods

In this cross-sectional study, the RT-PCR test was performed for a total of 10,581 HCWs suspicious of Covid-19 infection. For each HCW, the frequency of SARS-CoV-2 infection and the time of transmission based on vaccination administration time and schedule were examined during different waves of the pandemic. Based on these findings, the study patients were divided into three groups: natural, natural/breakthrough, and breakthrough.

Results

In total, 53% of the HCWs were exposed to SARS-CoV-2 infection between 1 and 5 times within two years after the current pandemic, while 20.7% and 32.3% experienced natural and breakthrough SARS-CoV-2 infection, respectively. Only 6% of the breakthrough-infected HCWs had naturally contracted SARS-CoV-2 infection during the initial waves. The highest natural peaks of infection occurred during the interval administration of the first and second dose of the first vaccination series, while the single highest peak of breakthrough infection belonged to the Omicron wave. It occurred simultaneously with the administration of the third vaccination dose. On the other hand, the highest rate of reinfection was observed amongst people who had received the Sinopharm and Bharat vaccines full-doses.

Conclusion

This study compared the clinical differences between the two peaks of Omicron and Delta. This study indicates the rates of natural and breakthrough SARS-CoV-2 infections according to vaccination schedules and different waves of the pandemic.
The International Center for Alcohol Policies (ICAP) book series: a key resource globally for alcohol industry political strategies
Authors: Bartlett Andrew , McCambridge Jim
Published: August 2023

This study examines the functions and purposes of the International Center for Alcohol Policies (ICAP) book series, published by Routledge between 1998 and 2010. The books were authored by invited academics, ICAP staffers, and alcohol industry representatives.

The key data source for this paper was the framing material – forewords, introductions, conclusions – of the books. A thematic analysis positioned the contents with regard to ongoing alcohol research and public health policy issues.

This was a project to ‘shift the paradigm’. ICAP frames alcohol policy choices in ways which direct policy attention to sub-groups rather than the population level. Population-level approaches are caricatured as ‘ideological’. The concept of ‘balance’ is prominent and is employed in multiple ways. Business interests are elided and industry involvement in policy making is promoted on scientific grounds. The intellectual programme is lent credibility by leading scientists and the imprimatur of an academic publisher.

While this attempt to change the paradigm in alcohol science has failed, ineffective alcohol policies remain common, uninformed by scientific evidence on how harms at the societal level may be reduced. The ICAP book series continues to serve its function as a resource to support the status quo in respect of alcohol policy.
Application of postmortem computed tomography angiography to settle a medical dispute after aortic dissection surgery: a forensic case report
Authors: Zhuoqun Wang , Zhiling Tian , Lei Wan , Hewen Dong , Donghua Zou , Jianhua Zhang , Ningguo Liu
Published: August 2023

Background

In the present case, we applied postmortem computed tomography angiography (PMCTA) in a medical dispute involving sudden death after cardiovascular surgery.

Case presentation

A 39-year-old man underwent aortic arch replacement combined with stented elephant trunk implantation surgery under extracorporeal circulation. All vital signs were stable and he was arranged for discharge seven days after surgery. Several days later, the patient was sent back to the hospital for chest pain and poor appetite. Unfortunately, his condition worsened and he ultimately died. PMCT scanning detect pericardial effusion. Family members suspected that the surgical sutures were not dense enough, causing the patient’s postoperative bleeding and resulting in cardiac tamponade and death. PMCTA was performed before autopsy, which showed pericardial effusion. However, postmortem angiography with simulated blood pressure showed no leakage of contrast agent, which guided the subsequent autopsy and histological examinations.

Conclusions

While many previous postmortem imaging case reports have shown positive results that provided evidence of medical malpractice, the current case excludes the possibility of physician negligence and reasonably settles the medical dispute from another perspective. In short, the PMCTA approach we describe here was an effective tool that can be applied to certain medical-related forensic cases.
Nasogastric tube insertion length measurement and tip verification in adults: a narrative review
Authors: Boeykens Kurt , Holvoet Tom , Duysburgh Ivo
Published: August 2023

Nasogastric feeding tube insertion is a common but invasive procedure most often blindly placed by nurses in acute and chronic care settings. Although usually not harmful, serious and fatal complications with misplacement still occur and variation in practice still exists. These tubes can be used for drainage or administration of fluids, drugs and/or enteral feeding. During blind insertion, it is important to achieve correct tip position of the tube ideally reaching the body of the stomach. If the insertion length is too short, the tip and/or distal side-openings at the end of the tube can be located in the esophagus increasing the risk of aspiration (pneumonia). Conversely, when the insertion length is too long, the tube might kink in the stomach, curl upwards into the esophagus or enter the duodenum. Studies have demonstrated that the most frequently used technique to determine insertion length (the nose–earlobe–xiphoid method) is too short a distance; new safer methods should be used and further more robust evidence is needed. After blind placement, verifying correct gastric tip positioning is of major importance to avoid serious and sometimes lethal complications.
Dysbiosis of gut microbiota during fecal stream diversion in patients with colorectal cancer
Authors: Lee Soo Young , Park Hyeung-Min , Kim Chang Hyun , Kim Hyeong Rok
Published: August 2023

Background

The effect of fecal stream diversion on the gut microbiota is still uncertain. The present study was designed to assess the effect of fecal stream diversion on the composition of the gut microbiota in patients with colorectal cancer. We included patients undergoing left-sided colorectal cancer surgery with (ileostomy group) or without (control group) diverting ileostomy. Fecal samples were collected from 10 patients in each group before surgery (t1) and after ileostomy repair in the ileostomy group and 6–12 months after the initial surgery in the control group (t2). The fecal microbiota was assessed using 16S rRNA sequencing, and changes in the composition of the fecal microbiota were compared between the two groups.

Results

Alpha diversity analysis revealed that the complexity of fecal microbiota decreased between t1 and t2 only in the ileostomy group. Beta diversity analysis also showed dissimilarity between t1 and t2 only in the ileostomy group. The composition of the microbiota was similar between the two groups at t1. However, at t2, the ileostomy group had lower proportion of beneficial bacteria (Lachnospiraceae, 3.8% vs. 29.9%, p < 0.001; Ruminococcaceae, 0.6% vs. 18.4%, p < 0.001; Blautia, 0.1% vs. 9.1%, p < 0.001; Faecalibacterium, 0.2% vs. 7.5%, p < 0.001) and a higher proportion of harmful bacteria (Proteobacteria, 17.9% vs. 5.1%, p = 0.006; Clostridium, 16.2% vs. 1.1%, p = 0.013; Streptococcus, 17.7% vs. 1.6%, p = 0.002) than the control group.

Conclusions

Fecal stream diversion was closely associated with less diversity and dysbiosis of the gut microbiota.
Pastoralism in South Asia: Contemporary stresses and adaptations of Himalayan pastoralists
Authors: Singh Rashmi , Kerven Carol
Published: August 2023

We discuss the main findings in the Special issue on Pastoralism in South Asia from the eight papers based on research conducted in the Himalayan region of South Asia. An overview is presented of pastoralism in the Himalayan region, including India, Pakistan, Nepal and Bhutan. Drawing parallels with the global stresses to pastoralists, papers in this special issue highlighted three sets of contemporary stresses to the pastoralists of the Himalayan region viz. (a) lack of herding labour, associated changing aspirations of youth and decline in traditional knowledge systems; (b) continued stresses from the state and between the formal and informal institutions; and (c) climatic stresses and associated impacts on the rangeland and livestock health. A synthesis of findings from all eight case studies suggests how the issues around pastoral livelihoods and rangeland management in the Himalayan region are entangled across social, political and ecological dimensions. However, instead of only being impacted by the stresses, the pastoral communities are showing adaptations to various kinds of uncertainties and variabilities. Based on these findings from across eight sites in the Himalayan region, we argue that understanding of the problems as well as proposed solutions from the policymakers should be tailored according to the particular social, political and ecological contexts. Other than the issues given prominence in this special issue, the role of markets and social security are some of the other important concerns to be addressed in the region, which can be best addressed by creating an interface between pastoralists and policymakers, practitioners and the government, while making the best use of pastoral knowledge and their way of life.
HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p
Authors: Luo Wenqin , Xu Zhehao , Wang Huan , Lu Zeyi , Ding Lifeng , Wang Ruyue , Xie Haiyun , Zheng Qiming , Lin Yudong , Zhou Zhenwei , Li Yang , Chen Xianjiong , Li Gonghui , Xia Liqun
Published: August 2023

Background

Renal cell carcinoma (RCC) is characterized by a high rate of distant metastasis, which leads to poor prognosis in patients with advanced RCC. PUS10 has been recognized as a member of the pseudouridine synthase family, and recently other functions beyond the synthesis of the RNA modification have been uncovered. However, little is known about its role in diseases such as cancer.

Methods

RT-qPCR, western blot and immunohistochemistry were used to measure the expression of PUS10 in RCC tissues. Transwell assay, wound healing assay, and in vivo metastasis model were conducted to determine the function of PUS10 in RCC progression. MicroRNA sequencing and GEO database were used to screen for the downstream microRNAs of PUS10. RNA immunoprecipitation, dual luciferase reporter assay, immunostaining, and rescue experiments were employed to establish the PUS10/miR-194-5p/nuclear distribution protein C(NUDC)/Cofilin1 axis in RCC migration. Chromatin immunoprecipitation and dual luciferase reporter assay were used to verify its upstream transcriptional regulator.

Results

The expression of PUS10 was significantly decreased in RCC tissues, and low expression predicted poor prognosis. In vitro and in vivo experiments showed that PUS10 suppressed RCC migration, which, however, was independent of its classical pseudouridine catalytic function. Mechanically, PUS10 promoted the maturation of miR-194-5p, which sequentially inhibited RCC migration via disrupting NUDC-dependent cytoskeleton. Furthermore, hypoxia and HIF-1 A were found involved in the downregulation of PUS10.

Conclusion

We unraveled PUS10 restrained RCC migration via the PUS10/miR-194-5p/NUDC/Cofilin1 pathway, which independent of its classical catalytic function. Furthermore, a linkage between the critical tumor microenvironment hallmark with malfunction of the forementioned metastasis inhibition mechanism was presented, as demonstrated by repressed expression of PUS10 due to hypoxia and HIF-1A.
Evaluation of the safety and efficacy of extracorporeal carbon dioxide removal in the critically ill using the PrismaLung+ device
Authors: Tiruvoipati Ravindranath , Ludski Jarryd , Gupta Sachin , Subramaniam Ashwin , Ponnapa Reddy Mallikarjuna , Paul Eldho , Haji Kavi
Published: August 2023

Background

Several extracorporeal carbon dioxide removal (ECCO2R) devices are currently in use with variable efficacy and safety profiles. PrismaLung+ is an ECCO2R device that was recently introduced into clinical practice. It is a minimally invasive, low flow device that provides partial respiratory support with or without renal replacement therapy. Our aim was to describe the clinical characteristics, efficacy, and safety of PrismaLung+ in patients with acute hypercapnic respiratory failure.

Methods

All adult patients who required ECCO2R with PrismaLung+ for hypercapnic respiratory failure in our intensive care unit (ICU) during a 6-month period between March and September 2022 were included.

Results

Ten patients were included. The median age was 55.5 (IQR 41–68) years, with 8 (80%) male patients. Six patients had acute respiratory distress syndrome (ARDS), and two patients each had exacerbations of asthma and chronic obstructive pulmonary disease (COPD). All patients were receiving invasive mechanical ventilation at the time of initiation of ECCO2R. The median duration of ECCO2R was 71 h (IQR 57–219). A significant improvement in pH and PaCO2 was noted within 30 min of initiation of ECCO2R. Nine patients (90%) survived to weaning of ECCO2R, eight (80%) survived to ICU discharge and seven (70%) survived to hospital discharge. The median duration of ICU and hospital stays were 14.5 (IQR 8–30) and 17 (IQR 11–38) days, respectively. There were no patient-related complications with the use of ECCO2R. A total of 18 circuits were used in ten patients (median 2 per patient; IQR 1–2). Circuit thrombosis was noted in five circuits (28%) prior to reaching the expected circuit life with no adverse clinical consequences.

Conclusion(s)

PrismaLung+ rapidly improved PaCO2 and pH with a good clinical safety profile. Circuit thrombosis was the only complication. This data provides insight into the safety and efficacy of PrismaLung+ that could be useful for centres aspiring to introduce ECCO2R into their clinical practice.
Spatial pattern of arsenic concentration and associated noncarcinogenic health risk assessment: a case study on Gangni Union of Chuadanga district of Bangladesh
Authors: Islam Md. Nazrul , Haque Md. Inzamul , Hossain Md. Anik
Published: August 2023

Groundwater is one of the world’s most important sources of fresh drinking water. Various contaminants mix with groundwater and alter its natural composition, such as arsenic. This study aimed to ascertain the present condition of arsenic concentration, its spatial pattern, and its relationship with tube well depth in the Gangni Union in the Chuadanga district of Bangladesh. Additionally, the study tried to assess the associated noncarcinogenic health risks imposed by oral ingestion of arsenic. Systematic sampling was used to collect water samples $$(n=100)$$

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 along with depth information from the sample tube wells. Water samples were analyzed with the pre-calibrated Hach EZ, Dual-Range Arsenic Test Kit (Range: 0.00–0.5 mg/l). Both geostatistical (spatial autocorrelation, Hotspot analysis, and IDW) and statistical (descriptive and correlation statistics) methods were used. The resultant arsenic content of the samples tested ranges from 0.0004 (mg/l) to 0.10 (mg/l). Arsenic levels in almost 42% of the samples exceeded the WHO standard, 21% exceeded the Bangladesh standard, and 37% were within the tolerable standard. Geostatistical analysis shows that approximately 63% of the total area is arsenic contaminated. Furthermore, hotspot analysis reveals that the northeastern and southeastern parts of the study area are more arsenic-contaminated than the other parts. Noncarcinogenic health risk assessment shows that children have a higher average daily dose (ADD) range (8.33E-06-0.00181) than adults (2.78E-06-0.0006). Similarly, the hazard quotient (HQ) value is also higher for children (0.0277–6.033) than for adults (0.0092–2.011). The result of Pearson’s correlation coefficient, r (98) = − 0.7580, p = 0.000, shows a negative linear relationship between concentration values and depth, meaning that increasing depth will reduce arsenic contamination from tube well water.
Interaction of surfactants with Prunus laurocerasus leaf surfaces: time-dependent recovery of wetting contact angles depends on physico-chemical properties of surfactants
Authors: Baales Johanna , Zeisler-Diehl Viktoria V. , Narine Suraya , Schreiber Lukas
Published: August 2023

Background

Surfactants are added to spray solutions because they significantly improve foliar uptake of active ingredients (AIs) into the leaves. It was intended to investigate whether surfactant solutions forming a dried deposit on Prunus leaf surfaces after they were sprayed, lead to structural and functional changes of the cuticle/atmosphere interface. This could potentially result in irreversibly enhanced leaf surface wetting, which should be of major disadvantage. Enhanced wetting could promote leaching of ions and promote leaf surface colonization with microorganisms.

Results

Prunus laurocerasus leaf surfaces were sprayed with aqueous solutions of non-ionic alcohol ethoxylates, a cationic, an anionic and one large polar surfactant. Directly after spraying and drying of the different surfactant solutions, wetting contact angles of deionized water (without surfactant) were significantly lower (between 6 and 54°) compared to wetting contact angles on untreated leaves (77°). Leaf surface wettability with deionized water was more pronounced with non-ionic alcohol ethoxylates (wetting contact angles ranging between 6 and 22°) compared to the other 3 surfactants (wetting contact angles ranging between 42 and 54°). Wetting contact angles of deionized water on leaf surfaces treated with non-ionic alcohol ethoxylates continuously increased again over time resulting in final wetting contact angles not different from untreated leaf surfaces. The time-dependent recovery of wetting contact angles was dependent on the degree of ethoxylation of the non-ionic alcohol ethoxylates. The wetting contact angle recovery rate was lower the higher the degree of ethoxylation of the alcohol ethoxylates was. With the cationic, anionic and large polar surfactant a recovery of wetting contact angles was not observed. In addition, on fully dehydrated and dead leaves wetting contact angle recovery was not observed for any of the tested surfactants after spraying and drying. Analytical determinations of the amounts of alcohol ethoxylates on the leaf surfaces after spraying and drying showed that amounts of alcohol ethoxylates decreased over time on the surface (24–72 h).

Conclusion

Our results indicate that non-ionic alcohol ethoxylates diffused within hours from the leaf surface into the leaf over time and thus fully disappeared from the leaf surface. This was not the case with the cationic, anionic and the large polar surfactants remaining on the leaf surface.

Graphical Abstract
On the use of tsunami-source data for high-resolution fault imaging of offshore earthquakes
Authors: Kubo Hisahiko , Kubota Tatsuya , Suzuki Wataru , Nakamura Takeshi
Published: August 2023

The source imaging for offshore earthquakes using terrestrial geodetic data has a limited estimation performance due to the low data resolution. One approach to overcome this limitation is the use of seafloor geodetic data. In this study, we focus on tsunami-source data, which is the spatial distribution of vertical crustal displacements above the source area and can be derived from tsunami waveform records. We evaluate how the use of this spatial seafloor geodetic data improves the estimation of a rectangular fault model. Here, the fault model of the 2016 off-Fukushima earthquake in Japan, which was a shallow intraplate earthquake (Mw 7.0), was estimated by three inversions: terrestrial Global Navigation Satellite System (GNSS) data only, tsunami-source data only, and a combination of the GNSS data and tsunami-source data. A Bayesian inversion approach was used to understand the distribution of the estimated fault parameters and their relationship. The results indicated that the terrestrial GNSS data have a low resolution for the analysis of the offshore earthquake, which resulted in a biased solution with large uncertainty. Conversely, the use of tsunami-source data significantly improved the resolution and reliability of source imaging and reduced the dependency among fault parameters. These results suggested that the high-spatial-resolution information of tsunami source is a powerful tool in source imaging of offshore shallow earthquakes. Moreover, the combined use of the two different geodetic data leads to a more robust estimation of fault parameters. We believe that the use of tsunami-source data is useful, not only for the post hoc source analysis, but also for estimating an earthquake rupture area just after a large earthquake, where GNSS data are currently used.

Graphical Abstract
Recent global nonhydrostatic modeling approach without using a cumulus parameterization to understand the mechanisms underlying cloud changes due to global warming
Authors: Noda Akira T. , Ohno Tomoki , Kodama Chihiro , Chen Ying-Wen , Kuba Naomi , Seiki Tatsuya , Yamada Yohei , Satoh Masaki
Published: August 2023

Clouds are the primary source of uncertainty in the prediction of climate change. To reduce the uncertainty of cloud simulations and overcome this difficulty in prediction, many climate modeling centers are now developing a new type of climate model, the global nonhydrostatic atmospheric model, which reduces the uncertainty arising from a cumulus parameterization by computing clouds explicitly using a cloud microphysics scheme. Among the global nonhydrostatic atmospheric models used in recent intercomparison studies, NICAM aims to project climate change by improving our understanding of cloud changes due to warming and related physical processes. NICAM is the first global nonhydrostatic model and was developed by our research team. This review summarizes the outcomes of a recent major five-year research program in Japan for studying climate using NICAM, as well as providing an overview of current issues regarding the use of global kilometer-scale simulations in high-resolution climate modeling.
Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery
Authors: Wuputra Kenly , Tsai Ming-Ho , Kato Kohsuke , Ku Chia-Chen , Pan Jia-Bin , Yang Ya-Han , Saito Shigeo , Wu Chun-Chieh , Lin Ying-Chu , Cheng Kuang-Hung , Kuo Kung-Kai , Noguchi Michiya , Nakamura Yukio , Yoshioka Tohru , Wu Deng-Chyang , Lin Chang-Shen , Yokoyama Kazunari K.
Published: August 2023

Background

Crosstalk between the aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is called the “AhR–Nrf2 gene battery”, which works synergistically in detoxification to support cell survival. Nrf2-dependent phase II gene promoters are controlled by coordinated recruitment of the AhR to adjacent dioxin responsive element (DRE) and Nrf2 recruitment to the antioxidative response element (ARE). The molecular interaction between AhR and Nrf2 members, and the regulation of each target, including phase I and II gene complexes, and their mediators are poorly understood.

Methods

Knockdown and forced expression of AhR–Nrf2 battery members were used to examine the molecular interactions between the AhR–Nrf2 axis andAhRpromoter activation. Sequential immunoprecipitation, chromatin immunoprecipitation, and histology were used to identify each protein complex recruited to their respectivecis-elements in theAhRpromoter. Actin fiber distribution, cell spreading, and invasion were examined to identify functional differences in the AhR–Jdp2 axis between wild-type andJdp2knockout cells. The possible tumorigenic role of Jdp2 in the AhR–Nrf2 axis was examined in mutantKras-Trp53-driven pancreatic tumors.

Results

Crosstalk between AhR and Nrf2 was evident at the transcriptional level. TheAhRpromoter was activated by phase I ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the AhR–Jdp2–Nrf2 axis in a time- and spatial transcription-dependent manner. Jdp2 was a bifunctional activator of DRE- and ARE-mediated transcription in response to TCDD. After TCDD exposure, Jdp2 activated theAhRpromoter at the DRE and then moved to the ARE where it activated the promoter to increase reactive oxygen species (ROS)-mediated functions such as cell spreading and invasion in normal cells, and cancer regression in mutantKras-Trp53-driven pancreatic tumor cells.

Conclusions

Jdp2 plays a critical role inAhRpromoter activation through the AhR–Jdp2–Nrf2 axis in a spatiotemporal manner. The AhR functions to maintain ROS balance and cell spreading, invasion, and cancer regression in a mouse model of mutantKras–Trp53pancreatic cancer. These findings provide new insights into the roles of Jdp2 in the homeostatic regulation of oxidative stress and in the antioxidation response in detoxification, inflammation, and cancer progression.
Age and sex dependent differences in midline facial soft tissue thicknesses measured on MRI scans of Northwest Indian subjects: a forensic anthropological study
Authors: Thakur Shubham , Sehrawat J. S.
Published: August 2023

Background

Human face is complex and intricate structure, with several features that are unique to each individual and can be taken as an identity pass in this mortal world. The facial profile of an individual holds materialistic value and is crucial for human identification. Present study aims to investigate the influence of sex and age of an individual on the soft tissue thicknesses (FSTT) at midline facial landmarks estimated on MRI scans.

Methods

Facial soft tissue thickness was estimated at 20 midline landmarks on the MRI scans of 120 (57 male; 63 female) anatomically normal Northwest Indian adult subjects (18–70 + years age-group). Age and sex dependent variations in tissue thicknesses at different landmarks were estimated using statistical software IBM SPSS Statistics 23.

Results

The results of the study yielded that most of the midline landmarks had higher values in males than in females indicating observable sexual dimorphism in FSTT values in this facial region, statistically significant differences were also noted in soft tissue thickness estimates of different age-groups, showing increasing or decreasing trend with age. The mid-facial landmarks like mid-philtrum, supra-dentale, incisor superius, and labile inferius displayed highly significant p values.

Conclusions

Present study results were in tandem with the findings of previous studies; males and younger age-group individuals were having higher tissue thickness values than the females and older individuals, respectively. The highest soft tissue estimates were obtained for the middle age subjects and the most aged individuals had the least midline soft tissue thickness values. These results can have significant forensic anthropological repercussions in attempting facial approximations on unknown skulls and identification of unknown individuals from still images, photographs or videos.
Cerebrolysin recovers diaphragmatic function and reduces injury-associated astrogliosis following a cervical spinal cord hemi-section injury in rats
Authors: Fouad Samah , Elfarrash Sara , Rizk Awad , Rezk Shaymaa , Mosbah Esam , Saad Mohamed-Ahdy , Awad Basem I.
Published: August 2023

Background

Spinal cord injury (SCI) is widely considered the most disastrous medical condition. With no available treatment to date, SCI continues to cause disabilities to the patients and affect their own and their caregivers' quality of life. Cerebrolysin (CBL) is a neuropeptide preparation derived from purified brain proteins with suggested neuroprotective and neurotrophic properties. CBL showed earlier the ability to target multiple pathways that helped in the improvement of the recovery following different groups of neurological diseases and injuries, including ischemic stroke, traumatic brain injuries, and even neurodegenerative diseases. In the current study, the neuroprotective effect of CBL following a SCI is called into question using a rat model of spinal cord cervical hemi-section validated earlier by our lab and others. Using 32 rats divided into four groups randomly, CBL treatment was implemented for either 7 or 21 days duration, following the cervical spinal cord hemi-section.

Results

Following the CBL treatment, rats with cervical cord hemi-section showed functional improvement of diaphragmatic muscle as recorded by electromyography (EMG). In addition, the histopathological assessment of the spinal cord showed improved neuronal viability and reduced astrogliosis at the site of the injury compared to the non-treated group. 21-day treatment showed significant improvement when compared to the shorter 7-day regimen.

Conclusion

Our data suggest that CBL is capable of protecting and regenerating anterior horn motor neurons with functional recovery of diaphragmatic muscle functions in rats, suggesting the potential use of CBL for future regenerative and neuroprotective therapy following SCI.
Risk factors of systemic lupus erythematosus: an overview of systematic reviews and Mendelian randomization studies
Authors: Xiao Xin-Yu , Chen Qian , Shi Yun-Zhou , Li Li-Wen , Hua Can , Zheng Hui
Published: August 2023

Background

The etiology of systemic lupus erythematosus is complex and incurable. A large number of systematic reviews have studied the risk factors of it. Mendelian randomization is an analytical method that uses genetic data as tool variables to evaluate the causal relationship between exposure and outcome.

Objective

To review the systematic reviews and Mendelian randomization studies that focused on the risk factors of systemic lupus erythematosus and shed light on the development of treatments for its prevention and intervention.

Methods

From inception to January 2022, we systematically searched MEDLINE (via PubMed) and Embase for related systematic reviews and Mendelian randomization studies. Extract relevant main data for studies that meet inclusion criteria. The quality of systematic reviews was assessed by using Assessment of Multiple Systematic Reviews 2 (AMSTAR-2). Finally, the risk factors are scored comprehensively according to the results’ quantity, quality, and consistency.

Results

Our study involved 64 systematic reviews and 12 Mendelian randomization studies. The results of systematic reviews showed that diseases (endometriosis, atopic dermatitis, allergic rhinitis), lifestyle (smoking, drinking, vaccination), and gene polymorphism influenced the incidence of systemic lupus erythematosus. The results of Mendelian randomization studies identified the role of disease (periodontitis, celiac disease), trace elements (selenium, iron), cytokines (growth differentiation factor 15), and gut microbiome in the pathogenesis of systemic lupus erythematosus.

Conclusion

We should pay attention to preventing and treating systemic lupus erythematosus in patients with endometriosis, celiac disease, and periodontitis. Take appropriate dietary supplements to increase serum iron and selenium levels to reduce the risk of systemic lupus erythematosus. There should be no excessive intervention in lifestyles such as smoking and drinking.
A systematic review on post-discharge venous thromboembolism prophylaxis in patients with COVID-19
Authors: Amani-Beni Reza , Kermani-Alghoraishi Mohammad , Darouei Bahar , Reid Christopher M.
Published: August 2023

Background

Coronavirus disease of 2019 (COVID-19) is associated with venous thromboembolism (VTE), not only during hospitalization but also after discharge, raising concerns about anticoagulant (AC) use for post-discharge COVID-19 patients. We aimed to systematically review the current literature on the possible benefits or risks regarding extended thromboprophylaxis.

Main body

We searched related databases from December 1, 2019, to October 6, 2022, including studies on the necessity, duration, and selection of the ideal AC regarding extended thromboprophylaxis for post-discharge COVID-19 patients. The screening of the selected databases led to 18 studies and 19 reviews and guidelines. Studies included 52,927 hospitalized COVID-19 patients, with 19.25% receiving extended thromboprophylaxis. VTE events ranging from 0 to 8.19% (median of 0.7%) occurred in a median follow-up of 49.5 days. All included studies and guidelines, except four studies, recommended post-discharge prophylaxis after an individual risk assessment indicating high thrombotic and low bleeding risk. Studies used risk assessment models (RAMs), clinical evaluation, and laboratory data to identify COVID-19 patients with a high risk of VTE. IMPROVE-DD was the most recommended RAM. Direct oral anticoagulants (DOACs) and low molecular weight heparins (LMWHs) were the most used AC classes.

Conclusions

Post-discharge prophylaxis for COVID-19 patients is recommended after an individual assessment. The IMPROVE-DD model can help predict VTE risk. After distinguishing patients who need post-discharge AC therapy, DOACs for 30–35 days and LMWHs for 40–45 days can be the drug of choice. Further studies, particularly the results of the ongoing randomized controlled trials (RCTs), are required. Also, to properly handle such patients, every physician should consider lifestyle modification in addition to pharmacological treatment for post-discharge VTE prophylaxis.
Evaluating the efficiency of a living wall facade as a sustainable energy-saving alternative in hot arid regions
Authors: Ramadhan Ayah Mohamed , Mahmoud Ayman Hassaan
Published: August 2023

Buildings can generate heat from a variety of sources, including building occupants, the sun, lighting and radiance, and cooling equipment, the energy consumed by which results in heat. Egypt is experiencing rapid economic growth, improvements in urban spaces, and a reduction in green space, all of which contribute to the occurrence of environmental problems such as pollutants, increased CO2 emissions, and increased energy consumption. Furthermore, the study focuses on the cases of architectural buildings that have been combined with living green facade as an innovative facade in order to address the energy crisis and climate change. The study on live greening techniques on building facades has raised a lot of interest. The primary purpose of this research is to utilize simulation software to manage the energy consumption usage of a green facade and compare energy demand levels to the basic scenario. Living green façades can offer zone-sensitive cooling on building facades, which is especially important during summer sessions in hot areas. Green facade cooling loads have an effect on interior air quality by keeping the façade from warming up. The research investigates the cooling impact of three types of living green walls in Egypt using Design-Builder simulation software. To estimate the energy consumption rates of the base case building, the Design-Builder simulation program was used in conjunction with the Energy Plus engine. According to the findings, the indirect green façade with planter boxes of green walls has reduced the high energy consumption compared to the buildings with direct and indirect green façade, increased thermal comfort, and reduced CO2 emissions. As a result of the estimation, it was determined that the energy demand standards of the living wall were lower than the energy demand standards of buildings without the living wall of the same measurement, saving 75% of the energy.
Improved geoelectrical resistivity monitoring for earthquake precursors near the Xinfengjiang reservoir of southern China, with a fixed Wenner array of downhole electrodes in four separated boreholes
Authors: Lu Jun , Xie Tao , Li Mei , Ye Qing , Yao Li , Wang Yali , Wang Zhongping , Yu Chen , Liu Jiping , Chai Jianyong
Published: August 2023

Over the past five decades, a geoelectrical resistivity monitoring experiment using fixed electrode arrays has been conducted at Heyuan in the Guangdong Province of China for detecting possible earthquake precursors near the Xinfengjiang reservoir. A pair of surface quasi-Wenner arrays designed to monitor temporal resistivity variations have been used in two oblique directions of N27°E and N80°W with electrode spacings AB/MN of 997 m/315 m and 1032 m/328 m, respectively. To reduce the effects of near-surface environmental changes, an improved experiment has been introduced in August 1992, using a subsurface Wenner array in the direction of N80°W with electrode spacings AB/MN of 54 m/18 m, consisting of downhole electrodes in four horizontally separated boreholes at the same depth of 65 m. During the experimental period of August 1992 to December 1996, a continuously downward trend in apparent resistivity with the improved downhole array and a peculiar annual variation with the conventional surface arrays have been observed. For the same period, no notable earthquakes occur in and around the Xinfengjiang reservoir. The field tests indicate that the downward trend of apparent resistivity was due to the aging of one of the current electrodes. By using simple layered models, we develop a sensitivity analysis to design a monitoring array with minimum environmental effects and to explain the observed resistivity variations, such as a paradoxical resistivity behavior related with negative sensitivity. No significant resistivity variations, which could be attributed to earthquake activity of magnitude 3.4 or less in the study area, are detected. We prove that the two monitoring methods with the modified subsurface Wenner and the conventional surface quasi-Wenner arrangements can complement each other to efficiently estimate a change in the electrical properties of rocks and reduce the ambiguity in the interpretation of apparent resistivity data.
Strategically positioning non-competitive individuals can rescue cooperation in scale-free networks
Authors: Wang Jianwei , Yu Fengyuan , Zhang Xinyi , Feng Xinwenqi , Chen Wei
Published: August 2023

Cooperation rescue in populations has long been a challenging problem, and previous studies have suggested that strategically placing cooperators in important positions in structured populations at the initial moment can obtain the opportunity of cooperation expansion. How to effectively lay out the location and place personalized nodes occupies a very important position in solving social dilemmas. However, most previous studies have focused on how the distribution of initial cooperators or defectors in homogeneous groups affects evolutionary outcomes, and relatively few studies have examined the placement of individuals with invariant heterogeneous characteristics. To enrich this research, we extend the cooperation rescue model to investigate the importance of the positional layout of two types of individuals with heterogeneous social value orientation characteristics in BA scale-free networks. Our study specifically investigates the impact of the distribution of non-competitive individuals on cooperation. We introduce non-competitive individuals into a BA scale-free network with only competitive individuals using different ranking rules. Our findings demonstrate that the presence of non-competitive individuals can promote cooperation. Furthermore, we determine the minimum number of nodes required to sustain cooperation under different ranking rules. In summary, our study emphasizes the importance of non-competitive individuals being placed in positions of importance for cooperation to flourish.
Comparison of Matlantis and VASP Bulk Formation and Surface Energies in Metal Hydrides, Carbides, Nitrides, Oxides, and Sulfides
Authors: Mine Shinya , Toyao Takashi , Shimizu Ken-ichi , Hinuma Yoyo
Published: August 2023

Generic neural network potentials without forcing users to train potentials could result in significant acceleration of total energy calculations. Takamoto et al. [Nat. Commun. (2022), 13, 2991] developed such a deep neural network potential (NNP) and made it available in their Matlantis package. Matlantis bulk formation energies of metal hydrides, carbides, nitrides, oxides, and sulfides were consistently ∼0.1 eV/atom larger and the surface energies were typically ∼10 meV/Å2 smaller than our previously calculated PBEsol(+U) VASP energies.
Interactions of Mono- and Divalent Host Molecules with Multi- and Divalent Guest Molecules
Authors: Ishitsuka Koki , Nakahata Masaki , Kamon Yuri , Hashidzume Akihito
Published: August 2023

The interactions of mono- and divalent host molecules with multi- and divalent guest molecules in aqueous media were investigated by steady-state fluorescence or NMR measurements. The multivalent and two-step interactions were observed depending on the combination of the host and guest molecules.
Supporting Physical Activity Lifestyle Change
Authors: Breckon Jeff
Published: August 2023

Apply it!

By reading this article, you will learn:

• By “coming alongside” the athlete, you will begin to build greater engagement and have the athlete demonstrate greater autonomy toward their change.

• To avoid “traps” in the conversation such as the expert trap, question–answer trap, and prematurely fixing without fully understanding the athlete's perception of the challenge.

• To use the athlete as the best resource for change strategies—work together to identify action plans that are flexible and based on their readiness to change.

• Relapse is a normal part of change; be patient and flexible as the athlete experiences how this feels and build in maintenance strategies to the change plan.
Identification of macronutrients by FT-IR analysis and physicochemical characterization of snacks elaborated from quinoa (Chenopodium quinoa Willd) and sacha inchi (Plukenetia volubilis)
Authors: Castillo-Guaca Sandra María , Muñoz-Pabon Karen Sofia , Bravo-Gómez Jesús Eduardo , Roa-Acosta Diego Fernando , Vergara Escobar Juan Fernando
Published: August 2023

Background: Currently, the consumption of high-protein foods that replace animal sources is increasing, a trend that promotes the design of new food systems. Spectroscopy methods with physicochemical tests allow for rapid and reliable identification of macronutrients and bioactive compounds.

Methods: Snacks were made using hyperproteic quinoa flour (HPQF) and sacha inchi flour (SIF) through an extrusion process and subsequent compression molding. Spectra infrared (IR) analysis was used to identify macronutrients such as starch, proteins, lipids, and fiber. Specific frequencies were selected that provided the greatest discrimination of the sample. Physicochemical measurements were performed using extractable (EPC) and hydrolyzable (HPC) phenolic compound analyses, carotenoid content, and antioxidant capacity through ABTS• + (2,2-azinobis- 3-ethylbenzothiazoline-6-sulphonic acid), DPPH (2,2-diphenyl-1-picrylhydrazyl), and FRAP (ferric reducing antioxidant power) methods. Color and texture parameters of the snacks were also measured.

Results: The identification of macronutrients using Fourier transform infrared spectroscopy – attenuated total reflectance (FTIR–ATR) was as follows: lipids showed two characteristic peaks at 2870 and 2960 cm−1; protein showed three peaks at 1540, 1630, and 1660 cm −1; starch showed two peaks at 1170 and 1155 cm −1. Regarding the content of free polyphenols, hydrolyzable polyphenols and carotenoids, the mixtures added with the highest inclusion of quinoa, i.e. 50%, showed the highest values of 3.05 mg GAE/g, 14.16 mg GAE/g and 14.06 µg-β carotene/g of dry base sample, respectively. The snacks showed significant differences (p<0.05) in the antioxidant properties determined by the ABTS and FRAP methods, with the highest values in the samples with 50% HPQF. The inclusion of HPQF was associated with a higher browning index, and snacks with a higher quinoa content exhibited greater hardness and crispness.

Conclusions: Snacks were obtained with protein percentages between 26–33%, containing bioactive compounds, gluten-free, and without the addition of oil during their production.