bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploration of Alternatives to Reduce the Gap in Access to Electricity in Rural Communities—Las Nubes Village Case (Barranquilla, Colombia)
Authors: Henao Alvin , Guzman Luceny
Published: January 2024

The global crisis associated with COVID-19 and the Russia-Ukraine conflict has affected progress towards the Sustainable Development Goals (SDGs). Projections for SDG7 (Ensure access to affordable, reliable, sustainable, and modern energy for all) indicate a slowdown in the pace of electrification. Thus, the problem of poverty will persist in many regions as long as access to electricity remains difficult. This work analyzes some solutions to the lack of electricity supply in a rural community using organic waste from its economic activity and the integration of other available renewable sources to make electricity affordable and reliable. A model that minimizes the levelized cost of energy and restricts the proportion of annual energy not supplied to less than 5% of the community’s annual demand optimizes the performance of off-grid and on-grid systems. These systems have in common the production of electricity from biogas produced from swine manure, supplemented with wind and solar generation. Batteries and diesel generators support the operation of off-grid systems. As expected, the grid-connected system presented the best performance; however, the result reaffirms the need for governments to ensure the policy and infrastructure conditions that facilitate the grid connection of vulnerable communities to achieve SDG7.
Effects of Pulsed Electric Field Pretreatment on Black Tea Processing and Its Impact on Cold-Brewed Tea
Authors: Yeo Hyunho , Kim Si-Yeon , Shahbaz Hafiz Muhammad , Jeong Se-Ho , Ju Hye-In , Jeon Ji-Hee , Lee Dong-Un
Published: January 2024

This study applied pulsed electric fields (PEFs) to accelerate the withering and drying processes during cold-brewed black tea production. PEF pretreatment was administered at 1.0, 1.5, and 2.0 kV/cm electric field strengths, combined with varying withering times from 8 to 12 hr. During the 12-hour withering process, the redness value (a*) and total color change (∆E) of PEF-treated leaves significantly increased (p < 0.05). Furthermore, the homogenous redness of tea leaves during fermentation depended on the PEF strength applied. In addition, PEF pretreatment remarkably reduced the drying time, up to a 50% reduction at a 2.0 kV/cm field strength. Additionally, the 2.0 kV/cm PEF-pretreated black tea exhibited a notable 42% increase in theaflavin (TF) content and a 54% increase in thearubigin (TR) content. Sensory evaluation scores were highest for black tea that received PEF pretreatment at 2.0 kV/cm. These findings highlight the significant potential of PEFs in enhancing the efficiency of withering and drying processes while positively impacting the physicochemical and sensory properties of cold-brewed black tea.
Tapioca Starch Improves the Quality of Virgatus nemipterus Surimi Gel by Enhancing Molecular Interaction in the Gel System
Authors: Huang Xiaobing , Liu Qingguan , Wang Pengkai , Song Chunyong , Ma Huanta , Hong Pengzhi , Zhou Chunxia
Published: January 2024

The gel prepared using Nemipterus virgatus (N. virgatus) surimi alone still has some defects in texture and taste. Complexing with polysaccharides is an efficient strategy to enhance its gel properties. The main objective of this study was to analyze the relationship between the gel quality and molecular interaction of N. virgatus surimi gel after complexing with tapioca starch. The results make clear that the gel strength, hardness, and chewiness of surimi gel were increased by molecular interaction with tapioca starch. At the appropriate addition amount (12%, w/w), the surimi gel had an excellent gel strength (17.48 N), water-holding capacity (WHC) (89.01%), lower cooking loss rate (CLR) (0.95%), and shortened T2 relaxation time. Microstructure analysis indicated that the addition of tapioca starch facilitated even distribution in the gel network structure, resulting in a significant reduction in cavity diameter, with the minimum diameter reduced to 20.33 μm. In addition, tapioca starch enhanced the hydrogen bonding and hydrophobic interaction in the gel system and promoted the transformation of α-helix to β-sheet (p < 0.05). Correlation analysis showed that the increased physicochemical properties of surimi gel were closely related to the enhanced noncovalent interactions. In conclusion, noncovalent complexation with tapioca starch is an efficient strategy to enhance the quality of surimi gel.
The Influence of Whey Protein Isolate on the Quality Indicators of Acidophilic Ice Cream Based on Liquid Concentrates of Demineralized Whey
Authors: Mykhalevych Artur , Buniowska-Olejnik Magdalena , Polishchuk Galyna , Puchalski Czesław , Kamińska-Dwórznicka Anna , Berthold-Pluta Anna
Published: January 2024

The use of liquid whey concentrates in the composition of ice cream, especially in combination with other powdered whey proteins, is limited due to their understudied properties. This article shows the main rheological and thermophysical characteristics of ice cream mixes, as well as color parameters, microstructure, analysis of ice crystals and quality indicators of ice cream during storage. The most significant freezing of free water (p ≤ 0.05) was observed in the temperature range from the cryoscopic temperature to −10 °C. The microscopy of experimental ice cream samples based on hydrolyzed whey concentrates indicates the formation of a homogeneous crystalline structure of ice crystals with an average diameter of 13.75–14.75 μm. Microstructural analysis confirms the expediency of using whey protein isolate in ice cream, which ensures uniform distribution of air bubbles in the product and sufficient overrun (71.98–76.55%). The combination of non-hydrolyzed whey concentrate and 3% whey protein isolate provides the highest stability to preserve the purity and color intensity of the ice cream during storage. The produced ice cream can be classified as probiotic (number of Lactobacillus acidophilus not lower than 6.2 log CFU/g) and protein-enriched (protein supply from 15.02–18.59%).
The Development of a Hybrid Model for Dam Site Selection Using a Fuzzy Hypersoft Set and a Plithogenic Multipolar Fuzzy Hypersoft Set
Authors: Majid Sheikh Zain , Saeed Muhammad , Ishtiaq Umar , Argyros Ioannis K.
Published: January 2024

Inrecent years, there has been a notable increase in utilising multiple criteria decision-making (MCDM) methods in practical problem solving. The advancement of enhanced decision models with greater capabilities, coupled with technologies like geographic information systems (GIS) and artificial intelligence (AI), has fueled the application of MCDM techniques across various domains. To address the scarcity of irrigation water resources in Bortala, Northwest China, the selection of a dam site has been approached using a hybrid model integrating a multipolar Fuzzy set and a plithogenic Fuzzy hypersoft set along with a GIS. This study considered criteria such as a geological layer, slope, soil type, and land cover. Four potential and reasonably suitable dam locations were identified using a dam construction suitability map developed for Bortala. Ultimately, we showcased the benefits of the innovative method, emphasizing an open, transparent, and science-based approach to selecting optimal dam sites through local studies and group discussions. The results highlight the effectiveness of the hybrid approach involving a fuzzy hypersoft set and plithogenic multipolar fuzzy hypersoft set in addressing the challenges of dam site selection.
Nutrient Characterization and Mineral Composition of Aruana in a Silvopastoral System with Nitrogen Fertilization
Authors: Baungratz Andressa Radtke , de Borba Leonardo Piffer , de Menezes Bruna Martins , Porsch Jean Lucas Macari , Venturini Tiago , Borquis Rusbel Raúl Aspilcueta , Mesquita Eduardo Eustáquio , Valente Ériton Egídio Lisboa , Macedo Vicente de Paulo
Published: January 2024

The objective was to characterize the nutrient and mineral composition of M. maximus cv Aruana grazed by lambs in a silvopastoral system or full sun with added nitrogen. The treatments are: (1) Aruana grazed in full sun with nitrogen fertilization, (2) Aruana grazed in full sun without nitrogen fertilization, (3) Aruana grazed in a silvopastoral system with nitrogen fertilization and (4) Aruana grazed in a silvopastoral system without nitrogen fertilization. The nutrient dynamics, urinary excretion of N and the amount returned of the nutrient were determined from four sheep in a Latin square experimental design; the analysis of the mineral composition of the leaves and stalks of the grass was carried out by collecting samples from the plots used, totaling six in each treatment evaluated. The silvopastoral system provided high levels of P and K in forage plants. Urinary N excretion and urine mineral contents were influenced by the systems evaluated and the use of N fertilizer. N did not show differences for leaves and canes.
Evidence-Based Implementation of the Family-Centered Model and the Use of Tele-Intervention in Early Childhood Services: A Systematic Review
Authors: Jimenez-Arberas Estibaliz , Casais-Suarez Yara , Fernandez-Mendez Alba , Menendez-Espina Sara , Rodriguez-Menendez Sergio , Llosa Jose Antonio , Prieto-Saborit Jose Antonio
Published: January 2024

Background: The purpose of this review is to explore the evidence and efficacy of two trends in early childhood intervention services: the family-centered model and the use of tele-intervention. Methods: A systematic review was carried out following the PRISMA methodology and using three databases: Web of Science, PubMed and Scopus. The studies included were those aimed at children from 0 to 6 years of age, focused on early intervention, and which alluded to the family-centered model and/or tele-intervention. Results: a total of 33 studies were included. Five main themes were identified: (1) The participation of children and family is facilitated and improved by the family-centered model of care; (2) the feeling of competence, self-efficacy, satisfaction and empowerment in professionals and families have a positive impact on quality of life; (3) the use of tele-intervention as a tool for prevention and intervention; (4) preparation for telepractice can improve the development of commitment; (5) tele-intervention as a possible solution to contextual barriers. Conclusions: Tele-intervention in pediatrics is presented as a tool inherent to the family-centered model since its implementation involves several common strategies. Future lines of research should explore the use of this tool as a possible solution to contextual barriers.
Project-Based Learning as a Potential Decolonised Assessment Method in STEM Higher Education
Authors: Lalujan Joanne Daniella , Pranjol Md Zahidul Islam
Published: January 2024

Decolonising the curriculum (DtC) is an emerging concept that continues to challenge higher education institutions globally, with educators and scholars increasingly recognising how traditional curricular structures, content, and pedagogical practices can reinforce colonial biases and marginalise certain student groups. DtC can be seen as a process rather than a phenomenon, one which is ongoing and multiplexed, consisting of elements that aim to dismantle the hierarchy between staff and students and question the ways in which knowledge is produced, valued, and disseminated. The expected outcome is to provide students with an education which is equitable, inclusive, and relevant to their personal lives and experiences. Efforts in DtC have continued to gain traction, but assessment practices remain overlooked as a crucial component, with most decolonising efforts focussed towards content and pedagogy. As such, this review aims to contribute to the conversation by exploring the roots and impacts of colonisation on higher education, particularly within the context of assessment in STEM subjects. We examine various elements of decolonised assessment methods and ultimately suggest project-based learning (PBL) as a comprehensive approach that brings together the aforementioned decolonial elements, illustrating this concept through the examination of a PBL assessment mode study conducted at the University of Sussex.
Bidirectional Allosteric Coupling between PIP2 Binding and the Pore of the Oncochannel TRPV6
Authors: Humer Christina , Radiskovic Tamara , Horváti Kata , Lindinger Sonja , Groschner Klaus , Romanin Christoph , Höglinger Carmen
Published: January 2024

The epithelial ion channel TRPV6 plays a pivotal role in calcium homeostasis. Channel function is intricately regulated at different stages, involving the lipid phosphatidylinositol-4,5-bisphosphate (PIP2). Given that dysregulation of TRPV6 is associated with various diseases, including different types of cancer, there is a compelling need for its pharmacological targeting. Structural studies provide insights on how TRPV6 is affected by different inhibitors, with some binding to sites else occupied by lipids. These include the small molecule cis-22a, which, however, also binds to and thereby blocks the pore. By combining calcium imaging, electrophysiology and optogenetics, we identified residues within the pore and the lipid binding site that are relevant for regulation by cis-22a and PIP2 in a bidirectional manner. Yet, mutation of the cytosolic pore exit reduced inhibition by cis-22a but preserved sensitivity to PIP2 depletion. Our data underscore allosteric communication between the lipid binding site and the pore and vice versa for most sites along the pore.
A Knockout of the IFITM3 Gene Increases the Sensitivity of WI-38 VA13 Cells to the Influenza A Virus
Authors: Eshchenko Natalya , Sergeeva Mariia , Zhuravlev Evgenii , Kudria Kira , Goncharova Elena , Komissarov Andrey , Stepanov Grigory
Published: January 2024

One of the ways to regulate the sensitivity of human cells to the influenza virus is to knock out genes of the innate immune response. Promising targets for the knockout are genes of the interferon-inducible transmembrane protein (IFITM) family, in particular the IFITM3 gene, whose product limits the entry of a virus into the cell by blocking the fusion of the viral and endosomal membranes. In this study, by means of genome-editing system CRISPR/Cas9, monoclonal cell lines with an IFITM3 knockout were obtained based on WI-38 VA13 cells (human origin). It was found that such cell lines are more sensitive to infection by influenza A viruses of various subtypes. Nevertheless, this feature is not accompanied by an increased titer of newly formed viral particles in a culture medium.
QTL Detection and Candidate Gene Identification for Eating and Cooking Quality Traits in Rice (Oryza sativa L.) via a Genome-Wide Association Study
Authors: Jiang Jianhua , Song Shaojie , Hu Changmin , Jing Chunyu , Xu Qing , Li Xinru , Zhang Mengyuan , Hai Mei , Shen Jiaming , Zhang Ying , Wang Dezheng , Dang Xiaojing
Published: January 2024

The eating and cooking quality (ECQ) directly affects the taste of rice, being closely related to factors such as gelatinization temperature (GT), gel consistency (GC) and amylose content (AC). Mining the quantitative trait loci (QTLs), and gene loci controlling ECQ-related traits is vital. A genome-wide association study on ECQ-related traits was conducted, combining 1.2 million single nucleotide polymorphisms (SNPs) with the phenotypic data of 173 rice accessions. Two QTLs for GT, one for GC and five for AC were identified, of which two were found in previously reported genes, and six were newly found. There were 28 positional candidate genes in the region of qAC11. Based on a linkage disequilibrium (LD) analysis, three candidate genes were screened within the LD region associated with AC. There were significant differences between the haplotypes of LOC_Os11g10170, but no significant differences were found for the other two genes. The qRT-PCR results showed that the gene expression levels in the accessions with high ACs were significantly larger than those in the accessions with low ACs at 35d and 42d after flowering. Hap 2 and Hap 3 of LOC_Os11g10170 reduced the AC by 13.09% and 10.77%, respectively. These results provide a theoretical and material basis for improving the ECQ of rice.
Fetal MRI-Based Mediastinal Shift Angle (MSA) and Percentage Area of Left Ventricle (pALV) as Prognostic Parameters for Congenital Diaphragmatic Hernia
Authors: Thater Greta , Angermann Lara , Virlan Silviu-Viorel , Weiss Christel , Rafat Neysan , Boettcher Michael , Elrod Julia , Bayer Tom , Nowak Oliver , Schönberg Stefan O. , Weis Meike
Published: January 2024

Objective: Fetal magnetic resonance imaging (MRI) is broadly used as a method for assessing prognosis in congenital diaphragmatic hernia (CDH). In addition to the extent of lung hypoplasia, determined by measuring the lung volume, cardiac impairment due to pulmonary hypertension and left cardiac hypoplasia is decisive for the prognosis. The percentage area of left ventricle (pALV) describes the percentage of the inner area of the left ventricle in relation to the total area, whereas the mediastinal shift angle (MSA) quantifies the extent of cardiac displacement. The prognostic value of pALV and MSA should be evaluated in terms of survival, the need for extracorporeal membrane oxygenation (ECMO) therapy, and the development of chronic lung disease (CLD). Methods: In a total of 122 fetal MRIs, the MSA and pALV were measured retrospectively and complete outcome parameters were determined regarding survival for all 122 subjects, regarding ECMO therapy in 109 cases and about the development of CLD in 78 cases. The prognostic value regarding the endpoints was evaluated using logistic regression and ROC analysis. Results: The MSA was significantly higher in children who received ECMO therapy (p = 0.0054), as well as in children who developed CLD (p = 0.0018). ROC analysis showed an AUC of 0.68 for ECMO requirement and 0.77 with respect to CLD development. The pALV showed a tendency towards higher levels in children who received ECMO therapy (p = 0.0824). The MSA and the pALV had no significant effect on survival (MSA: p = 0.4293, AUC = 0.56; pALV: p = 0.1134, AUC = 0.57). Conclusions: The MSA determined in fetal MRI is a suitable prognostic parameter for ECMO requirement and CLD development in CDH patients and can possibly be used as a supplement to the established parameters.
Optimal Antithrombotic Strategies in Cardiogenic Shock
Authors: Droppa Michal , Geisler Tobias
Published: January 2024

Cardiogenic shock (CS) represents a critical condition with a high mortality rate. The most common cause of CS is coronary artery disease, and patients typically present with myocardial infarction, necessitating immediate treatment through percutaneous coronary intervention (PCI) and often requiring mechanical circulatory support. CS is associated with a prothrombotic situation, while on the other hand, there is often a significant risk of bleeding. This dual challenge complicates the selection of an optimal antithrombotic strategy. The choice of antithrombotic agents must be personalized, taking into consideration all relevant conditions. Repeated risk assessment, therapeutic monitoring, and adjusting antithrombotic therapy are mandatory in these patients. This review article aims to provide an overview of the current evidence and practical guidance on antithrombotic strategies in the context of CS.
Welcome to the Journal of Market Access and Health Policy under MDPI Wings
Authors: Toumi Mondher
Published: January 2024

The Journal of Market Access and Health Policy (JMAHP) is the first peer-reviewed open access journal that focuses on the concept of ‘market access’ from economic, technical, scientific, sociological, anthropological, psychological, and policy perspectives [...]
Anti-Cryptosporidial Drug-Discovery Challenges and Existing Therapeutic Avenues: A “One-Health” Concern
Authors: Ali Munwar , Xu Chang , Nawaz Shah , Ahmed Ahmed Ezzat , Hina Qazal , Li Kun
Published: January 2024

Cryptosporidiosis is the leading cause of life-threatening diarrheal infection, especially in infants. Oocysts contaminate the environment, and also, being a zoonotic disease, cryptosporidiosis is a threat to One Health. Nitazoxanide is the only FDA-approved drug, effective only in immunocompetent adults, and is not safe for infants. The absence of mitochondria and apicoplast, the presence of an electron-dense band (ED band), hindrances in its genetic and phenotypic manipulations, and its unique position inside the host cell are some challenges to the anti-cryptosporidial drug-discovery process. However, many compounds, including herbal products, have shown efficacy against Cryptosporidium during in vitro and in vivo trials. Still, the “drug of choice” against this protozoan parasite, especially in immunocompromised individuals and infants, has not yet been explored. The One-Health approach addresses this issue, focusing on the intersection of animal, human, and environmental health. The objective of this review is to provide knowledge about novel anti-cryptosporidial drug targets, available treatment options with associated limitations, and possible future shifts toward natural products to treat cryptosporidiosis. The current review is organized to address the treatment and prevention of cryptosporidiosis. An anti-cryptosporidial drug that is effective in immunocompromised individuals and infants is a necessity of our time.
Synthesis and Prototyping of a Sit-to-Stand Assisting Device
Authors: Rea Pierluigi , Ruggiu Maurizio , Ottaviano Erika
Published: January 2024

Assistive and rehabilitation technologies deal with solutions aiming at sustaining or enhancing individual’s capabilities and autonomy, thereby improving their overall welfare. In the framework of devices developed for daily life activities, we focus our attention on Sit-to-Stand (STS) devices, by proposing an innovative solution based on a mechanism that has been synthesized, designed, built and tested as a prototype version for accomplishing the task. The developed mechatronic system serves the requested motions of standing and sitting, possessing the main features of compactness and customization for being embedded in chairs and conventional seats, according to a procedure that will be detailed in the paper. A simulation in a realistic scenario using a 3D model of an individual was carried out to size and verify the mechanical design and actuation. The mechatronic design of the system and its operations were reported using a laboratory prototype to show its engineering soundness and first experimental tests.
Tensor Conjugate Gradient Methods with Automatically Determination of Regularization Parameters for Ill-Posed Problems with t-Product
Authors: Wang Shi-Wei , Huang Guang-Xin , Yin Feng
Published: January 2024

Ill-posed problems arise in many areas of science and engineering. Tikhonov is a usual regularization which replaces the original problem by a minimization problem with a fidelity term and a regularization term. In this paper, a tensor t-production structure preserved Conjugate-Gradient (tCG) method is presented to solve the regularization minimization problem. We provide a truncated version of regularization parameters for the tCG method and a preprocessed version of the tCG method. The discrepancy principle is used to automatically determine the regularization parameter. Several examples on image and video recover are given to show the effectiveness of the proposed methods by comparing them with some previous algorithms.
Effect of Pre-Added HfO2 Inclusions on Carbide Morphology and Deformation Behavior in DZ125 Nickel-Based Superalloy
Authors: Feng Haoyuan , Liu Furong , Wang Qin , Wang Dinggang , Song Jinxia , Xiao Chengbo , Wu Yuhong
Published: January 2024

Inclusions are important phases affecting material properties in complicated ways. In this paper, a quantitative study of the addition of HfO2 inclusions to DZ125 nickel-based superalloys was performed. Experimental results showed that the introduction of HfO2 inclusions caused a loss of strength and ductility. The carbide morphology also changed significantly from skeletal-shaped to block-shaped, resulting in a remarkable discrepancy in the fracture behavior under quasi-in-situ tensile testing. The SEM dynamic observations showed that cracks were initiated from the skeletal carbides and almost failed to propagate into the matrix. In contrast, the damage behavior of block-shaped carbides also involved internal cracking but with a tendency to form interconnected microcracks during propagation. A crystal plasticity finite element model (CPFEM) method was further developed to study the stress/strain behavior during the deformation process, considering the crystal orientations and microstructure morphologies from the EBSD data. Those elastoplastic parameters were determined through nanoindentation experiments. Simulation results verified that blocky carbides produced a pronounced strain concentration at the interface of the carbides and matrix, thereby increasing the tendency of crack formation. This paper provides a fundamental understanding of the role of inclusions in material recycling applications.
Investigation of Surface Integrity of Conical Hole in Laser Polishing 440C Stainless Steel
Authors: Zhang Chuanqi , Cai Yukui , Zhang Haotian , Li Jiahang , Song Qinghua , Wang Bing , Liu Zhanqiang
Published: January 2024

In the machining process of 440C stainless steel using ball-end milling, the generation of machined traces is an inevitable outcome. Traditional polishing methods, when applied to the milling surfaces of small conical holes, exhibit significant limitations. However, the application of nanosecond pulsed laser polishing while maintaining dimensional integrity has proven effective in mitigating these issues. The parameters for the laser and scanning strategy were empirically determined through planar experiments. The results showed a reduction in surface roughness to a minimum value, representing a decrease of approximately 41.7%. Further validation experiments were conducted on the ball-milled surface of small conical holes. The rate of roughness reduction in these experiments surpassed that of planar surface polishing with an improvement of approximately 73.6%. The scanning strategy’s applicability was confirmed, and the post-polishing surface morphology was found to be largely in line with the prediction. The remelt layer and heat-affected zone resulting from nanosecond laser polishing were observed to be below 5 μm, significantly preserving the dimensional integrity of the conical hole’s internal surface. Moreover, nanosecond laser polishing was found to substantially enhance the surface hardness of the material, with an increase ranging from 100% to 180%. This study underscores the efficacy of nanosecond laser polishing in enhancing the internal surface of small conical holes, thereby improving the surface properties. Consequently, this method presents a reliable solution for the removal of machined traces from complex internal surfaces.
Determination and Characterization of Gold Nanoparticles in Liquor Using Asymmetric Flow Field-Flow Fractionation Hyphenated with Inductively Coupled Plasma Mass Spectrometry
Authors: Li Bin , Chua Sew Lay , Yu Dingyi , Chan Sheot Harn , Li Angela
Published: January 2024

The EU has approved the usage of gold as a food additive (E175) and it has been applied in numerous foods for coloring and decoration purposes. Different from the general assumption that edible gold is mainly present in the form of flakes or external coating in foods, this work demonstrated that gold nanoparticles (Au NPs) can be released from gold flakes and extracted under optimized conditions. To support future risk assessment associated with the exposure of Au NPs to human health, an effective approach was established in this study for both size characterization and mass determination of Au NPs released in a commercial gold-containing liquor using Asymmetric Flow Field-flow Fractionation (AF4) hyphenated with Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Our results showed that no Au NPs were detected in the original liquor product and only after ultrasonication for several minutes did Au NPs occur in the ultrasound-treated liquor. Particularly, Au NPs released in the liquor can be well extracted after 100-fold enrichment of gold flakes and the subsequent ultrasonication for 25 min. Size characterization of Au NPs was conducted by AF4-ICP-MS under calibration with Au NP standards. The gold particle sizes detected ranged from 8.3–398.0 nm and the dominant size of the released Au NPs was around 123.7 nm in the processed liquor. The mass concentration of gold particles determined in the liquor sample with gold flakes concentrated and subsequently sonicated was 48.1 μg L−1 by pre-channel calibration and the overall detection recoveries ranged over 82–95%. For the comparison control samples without ultrasonication, there was no detection of Au NPs. The established method was demonstrated to be useful for monitoring Au NPs in liquor and is possibly applied to other similar foodstuffs.
Diversity-Orientated Synthesis and Biological Properties of Compounds Based on the N-Phenylquinoneimine Scaffold
Authors: Adesina Adebimpe , Skouta Rachid
Published: January 2024

The N-phenylquinoneimine scaffold is a versatile synthetic platform that has gained significant attention in the field of drug discovery due to its structural diversity and capacity to interact with biologically relevant targets. This review explores established synthetic methodologies and highlights the significant biological activities exhibited by compounds derived from this scaffold, their implications for medicinal chemistry, and the development of novel therapeutics.
Synthesis of Bis(cyclic carbonates) from Epoxy Resin under Microwave Irradiation: The Structural Analysis and Evaluation of Thermal Properties
Authors: Hebda Edyta , Ozimek Jan , Szołdrowska Kinga , Pielichowski Krzysztof
Published: January 2024

This article describes the use of microwave irradiation in the synthesis of bis(cyclo carbonate) compounds (BCCs) in bulk (without solvent) from carbon dioxide capture using an epoxidized compound—a commercial epoxy resin—and compares this process to the conventional method. CO2 cycloaddition to epoxides is an ecological and efficient method for the formation of bis(cyclic carbonates). Moreover, the introduction of gas into the reaction mixture was carried out at atmospheric pressure with a controlled flow rate, which is advantageous from an economic point of view. Progressive structural changes and the presence of characteristic chemical groups were monitored using attenuated total reflectance infrared spectroscopy with Fourier transform. The obtained crude products were purified to obtain three fractions, which were subjected to detailed structural analysis using FT-IR and 13CNMR. The formation of the main product with two cyclic carbonates was confirmed. The presence of monomers, dimers and trimers in individual fractions as well as their thermal stability were determined, and the molecular masses in individual fractions were determined using gel permeation chromatography (GPC).
11B NMR of the Morphological Evolution of Traditional Chinese Medicine Borax
Authors: Li Qiulin , Yang Yawen , Wang Qingfeng , Han Xiang , Zhu Junfeng , Zhang Nan , Wang Qiuhong , Li Kanshe , Gong Pin , Chen Fuxin
Published: January 2024

This article applies nuclear magnetic resonance technology to the study of boron-containing traditional Chinese medicine, in order to explore the morphological evolution of boron elements in traditional Chinese medicine. Borax is a traditional Chinese medicine with anti-corrosion, anti-inflammatory, antibacterial, and anticonvulsant effects. It is made by boiling, removing stones, and drying borax minerals like borate salts. This article introduces an 11B nuclear magnetic resonance method for identifying and characterizing boron-containing compounds in TCM. We applied this technology to borax aqueous solutions in different chemical environments and found that with boron mixed in the form of SP2 hybridization in equilateral triangles and SP3 hybridization in equilateral tetrahedra, the pH changes in alkaline environments significantly affected the ratio of the two. At the same time, it was found that in addition to the raw material peak, boron signals of other boron-containing compounds were also detected in 20 commercially available boron-containing TCM preparations. These new boron-containing compounds may be true pharmaceutical active ingredients, and adding them directly to the formula can improve quality and safety. This article describes the detection of 11B NMR in boron-containing traditional Chinese medicine preparations. It is simple, non-destructive, and can provide chemical fingerprint studies for boron-containing traditional Chinese medicine.
Recent Advances in Functional Materials for Optical Data Storage
Authors: Dai Dihua , Zhang Yong , Yang Siwen , Kong Weicheng , Yang Jie , Zhang Jijun
Published: January 2024

In the current data age, the fundamental research related to optical applications has been rapidly developed. Countless new-born materials equipped with distinct optical properties have been widely explored, exhibiting tremendous values in practical applications. The optical data storage technique is one of the most significant topics of the optical applications, which is considered as the prominent solution for conquering the challenge of the explosive increase in mass data, to achieve the long-life, low-energy, and super high-capacity data storage. On this basis, our review outlines the representative reports for mainly introducing the functional systems based on the newly established materials applied in the optical storage field. According to the material categories, the representative functional systems are divided into rare-earth doped nanoparticles, graphene, and diarylethene. In terms of the difference of structural features and delicate properties among the three materials, the application in optical storage is comprehensively illustrated in the review. Meanwhile, the potential opportunities and critical challenges of optical storage are also discussed in detail.
Effect of Behavioral Activation for Women with Postnatal Depression: A Systematic Review and Meta-Analysis
Authors: Yisma Engida , Walsh Sandra , Steen Mary , Gray Richard , Dennis Shaun , Gillam Marianne , Parange Nayana , Jones Martin
Published: January 2024

Evidence shows that behavioral activation (BA), a simple form of psychological therapy, is as effective as the more complex psychological therapy—cognitive behavioral therapy (CBT)—in treating general depression. However, it remains unclear whether BA when compared with treatment-as-usual (TAU) has greater contributions in reducing postnatal depression. This systematic review compared the effect of BA versus TAU in reducing depression symptoms among postnatal women. Five databases (MEDLINE, Embase, Emcare, Cochrane Library, and PsycINFO) were searched. Risk of bias was assessed using the Cochrane Collaboration’s ‘risk-of-bias 2 tool’. A random-effects meta-analysis was conducted to examine the effect of BA on postnatal depression. Of 2844 initial studies, only two randomized control trials (RCTs) met the inclusion criteria. The overall quality of evidence of these two RCTs was low. When compared to TAU, meta-analysis showed that BA was associated with reduced depression symptoms in postnatal women (standard mean difference −0.56; 95% confidence interval −0.76 to −0.37). This review suggests that BA might be more effective than TAU for alleviating postnatal depression. However, due to concerns about evidence quality, these findings should be interpreted cautiously.
Lactoferrin and Lysozyme Inhibit the Proteolytic Activity and Cytopathic Effect of Naegleria fowleri Enzymes
Authors: Martinez-Castillo Moises , Ramírez-Rico Gerardo , Shibayama Mineko , de la Garza Mireya , Serrano-Luna Jesús
Published: January 2024

Naegleria fowleri is a ubiquitous free-living amoeba that causes primary amoebic meningoencephalitis. As a part of the innate immune response at the mucosal level, the proteins lactoferrin (Lf) and lysozyme (Lz) are secreted and eliminate various microorganisms. We demonstrate that N. fowleri survives the individual and combined effects of bovine milk Lf (bLf) and chicken egg Lz (cLz). Moreover, amoebic proliferation was not altered, even at 24 h of co-incubation with each protein. Trophozoites’ ultrastructure was evaluated using transmission electron microscopy, and these proteins did not significantly alter their organelles and cytoplasmic membranes. Protease analysis using gelatin-zymograms showed that secreted proteases of N. fowleri were differentially modulated by bLf and cLz at 3, 6, 12, and 24 h. The bLf and cLz combination resulted in the inhibition of N. fowleri-secreted proteases. Additionally, the use of protease inhibitors on bLf-zymograms demonstrated that secreted cysteine proteases participate in the degradation of bLf. Nevertheless, the co-incubation of trophozoites with bLf and/or cLz reduced the cytopathic effect on the MDCK cell line. Our study suggests that bLf and cLz, alone or together, inhibited secreted proteases and reduced the cytopathic effect produced by N. fowleri; however, they do not affect the viability and proliferation of the trophozoites.
A Pharmacist’s Role in a Case of Allergy Labeling and Acute Bacterial Rhinosinusitis Treatment
Authors: Undeberg Megan R. , Bowers Dana R. , Chau Cindy N. , McKeirnan Kimberly C.
Published: January 2024

This case report describes a pharmacist’s intervention with a 58-year-old female who presented with recurrent rhinosinusitis symptoms and limited treatment options due to a complicated allergy history. Using guidelines for treatment of acute bacterial rhinosinusitis coupled with a thorough antibiotic allergy assessment, the pharmacist developed a treatment plan that was acceptable to both the patient and the provider. Pharmacists can play an essential role in verification of allergies to both medications and non-pharmaceutical products, which further ensures patient safety as well as optimization of appropriate treatment methods.
Evaluation of Polyphenolic Profile and Antioxidant Activity of Sea Buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) Leaf and Berry Extracts Obtained via Optimized Microwave-Assisted and Accelerated Solvent Extraction
Authors: Čulina Patricija , Repajić Maja , Elez Garofulić Ivona , Dragović-Uzelac Verica , Pedisić Sandra
Published: January 2024

The aim of this study was to optimize parameters of microwave-assisted extraction (MAE) and accelerated solvent extraction (ASE) in terms of extraction temperature and time, microwave power and cycle numbers on the phenolic content of sea buckthorn leaves and berries, using 70% ethanol (v/v) as an extraction solvent. The characterization of phenolic composition in leaf and berry extracts obtained at optimal MAE and ASE conditions was performed with UPLC/ESI-MS2, while antioxidant activity was determined using the ORAC method. The optimal extraction conditions for MAE were 60 °C, 500 W and 15 min for leaves and 60 °C, 300 W, and 10 min for berries. The optimal extraction conditions for ASE from both leaves and berries were 120 °C, 15 min, and 3 cycles. Total phenolic content (TPC) in MAE and ASE extracts from leaves was similar to the TPC determined in extracts obtained by conventional extraction (60 °C/30 min); however, ASE contributed to the higher TPC of the berry extracts. The flavonols kaempferol-3-rutinoside in the leaves and kaempferol in the berries were the most abundant phenols of sea buckthorn. A higher antioxidant activity was found in the leaf extracts obtained by ASE and it correlated with the phenolic content. In general, ASE favored the extraction of all polyphenols from leaves, while MAE was more suitable for the extraction of flavonols from berries, suggesting that the choice of the optimal extraction method is crucial with regard to the target molecules and future applications.
Evaluation and Investigation of Hydraulic Performance Characteristics in an Axial Pump Based on CFD and Acoustic Analysis
Authors: Al-Obaidi Ahmed Ramadhan
Published: January 2024

In this work, the internal flow behaviour and characteristic pressure fluctuations of an axial pump with varying water conditions are analysed. The impact of tip vortex flow on the pattern of turbulent flow is simulated numerically by the application of the CFD technique and experimentally using an acoustics analysis method. The numerical CFD data are verified with an experimental test model for accuracy and reliability. Based on the results, the difference in pressure in the internal flow and at the surfaces of the blade can be impacted through tip leakage vortex regions, which leads to changes in internal flow. Subsequently, the flow in the clearance and tip leakage vortex regions is changed. Moreover, the results reveal that the suction wall upstream is more unsteady near the surface due to more mixing, secondary flow, and tip leakage vortices. Pressure fluctuation occurs near the tip of the blade, caused by the increasing vortex flow velocity and hence raising the turbulent kinetic energy (TKE). Using different monitoring points at the blade impeller reveals high values of the pulsation amplitude. Owing to the region of clearance backflow under low-water conditions, the axial pump displays larger fluctuations in pressure near the tip blade area. Because the leakage flow leaves the gap at a high flow rate, shear layers are formed quickly between the main flow and the leakage flow. Near the end wall, there is a negative-vorticity-induced vortex. Moreover, as the flow rate increases, the pump’s amplitude decreases along with its main frequency. For the low-water flow, the results reveal that there is an important clearance backflow because the axial pump has large clearance.
The Web of Life: A Critique of Nature, Wilderness, Gaia and the «Common Household»
Authors: Reijnen Anne Marie
Published: January 2024

A two-word summary of the following article might be «Words matter». It matters whether we conceive of the non-built world as nature, as «wilderness», as Gaia/Mother Earth, or as «our common home». We analyze the emergence of each of these four notions. Nature, by far the most multi-layered of the words, has a complex history rooted in the Greek word phusis. Nature is problematic because of its opposites: supernatural; nurture, culture and civilization. Nature seems to require dualism. Wilderness started out as something terrifying (the realm of the wild beasts), later acquiring a specific American understanding of an area conserved for recreation, of nature partially preserved, all desirable goals inspired by John Muir. In the Scriptures, wilderness becomes filled by promise. Gaia is short for the Gaia hypothesis of Earth as a living, self-regulating organism. It was coined by James Lovelock and Lynn Margulis and discussed critically by Bruno Latour. Compared with the view of the Earth as dead matter, «Gaia» is conducive to respect for all living beings. When it is coupled with Mother Earth, the concept becomes problematic from a feminist point of view. The common home or household stem from the teachings of Pope Francis. Although Laudato si’ is rightly viewed as a prophetic text regarding ecology and spirituality, «common home» implies a domestication of all that lives in a worldview that remains anthropocentric (homes are artefacts). A better concept is the «web of life» of which humankind is a part, but not the master. It is such a decentering that may herald hope for the Earth.
Prediction of Ground Wave Propagation Delay for MF R-Mode
Authors: Hehenkamp Niklas , Rizzi Filippo Giacomo , Grundhöfer Lars , Gewies Stefan
Published: January 2024

Time delays caused by ground wave propagation are the primary source of systematic error limiting the performance of the medium-frequency R-Mode radionavigation system. To achieve the desired ranging accuracy and compensate these delays, we have conceived a comprehensive correction scheme based on the prediction and application of the Atmospheric and Ground wave Delay Factor (AGDF). The AGDF was computed and mapped in 2D for a number of MF R-Mode transmitters in the Baltic Sea that were embedded into the receiver and evaluated during a large-scale measurement campaign. Our results show that the proposed AGDF approach is valid for the MF R-Mode system and provides accurate corrections of ground wave propagation delays within the performance requirements.
Intelligent Point Cloud Processing, Sensing, and Understanding
Authors: Wang Miaohui , Yue Guanghui , Xiong Jian , Tian Sukun
Published: January 2024

Point clouds are considered one of the fundamental pillars for representing the 3D digital landscape [...]
An Accuracy-Aware Energy-Efficient Multipath Routing Algorithm for WSNs
Authors: Dan Feng , Ma Yajie , Yin Wenqi , Yang Xian , Zhou Fengxing , Lu Shaowu , Ning Bowen
Published: January 2024

In the fields of industrial production or safety monitoring, wireless sensor networks are often content with unreliable and time-varying channels that are susceptible to interference. Consequently, ensuring both transmission reliability and data accuracy has garnered substantial attention in recent years. Although multipath routing-based schemes can provide transmission reliability for wireless sensor networks, achieving high data accuracy simultaneously remains challenging. To address this issue, an Energy-efficient Multipath Routing algorithm balancing data Accuracy and transmission Reliability (EMRAR) is proposed to balance the reliability and accuracy of data transmission. The multipath routing problem is formulated into a multi-objective programming problem aimed at optimizing both reliability and power consumption while adhering to data accuracy constraints. To obtain the solution of the multi-objective programming, an adaptive artificial immune algorithm is employed, in which the antibody initialization method, antibody incentive calculation method, and immune operation are improved, especially for the multipath routing scheme. Simulation results show that the EMRAR algorithm effectively balances data accuracy and transmission reliability while also saving energy when compared to existing algorithms.
Research on the Performance Path of Industrial Green Total Factor Productivity in the Context of High-Quality Development—Based on Fuzzy-Set Qualitative Comparative Analysis
Authors: Feng Yahong , Cheng Xinyi , Liu Ruihua
Published: January 2024

Improving industrial green total factor productivity (GTFP) is essential for achieving high-quality industrial development in China. To explore this perspective, we examined 30 provinces as case samples and applied a fuzzy-set qualitative comparative analysis in order to analyze the factors of technological innovation, human capital, green consumption, environmental regulation, the Internet, and external openness in relation to industrial GTFP. The findings of this study show that the configuration path of industrial GTFP has multiple concurrencies. Specifically, three paths were identified as leading to high industrial GTFP, namely, the “total factor type”, “open-technology drive type”, and “technology-human drive type”. Meanwhile, the two configuration paths of non-high-industrial GTFP displayed an asymmetric relationship. Overall, these findings are crucial in revealing the path to improving industrial GTFP and achieving high-quality industrial development in China. The “total-factor-type” and “open-technology-drive-type” paths were the most prevalent in the eastern region, while the central area leaned more towards the “technology-human drive type”. This study offers valuable recommendations and insights for policymakers and scholars interested in promoting the development of industrial GTFP.