bluuebunny/crossref_metadata_2025 huggingface dataset:
Physical and Physiological Properties and Mineral Content of Curly Lettuce Grown by Applying Different Rates of Biochar to the Soil with Varying Irrigation Water Levels
Authors: TÜFENKÇİ Şefik , YERLİ Caner
Published: August 2023

The crisis experienced from the water supply causes food production to be adversely affected in the agriculture sector, which is the biggest consumer of water. The deficit irrigation strategy ensures the continuity of food production as well as using water effectively. However, since the plant grown in this strategy is exposed to abiotic stress, it experiences significant yield and quality losses. For this reason, it is necessary to develop approaches to improve yield and quality losses of the plant grown with deficit irrigation. In this study, the physical and physiological properties and mineral content of curly lettuce (Lactuca sativa L. var. Crispa) grown by applying different rates of biochar to the soil (0%, 1%, 2%, 3%) with varying irrigation water levels (100%, 67%, 33%) researched. The study determined that decreasing irrigation water level decreased plant height, stem diameter, number of leaves, root wet and dry weights, plant weight, chlorophyll and leaf relative water contents, stomatal conductivity and N, P, K, Ca, Mg, Na, Fe, Cu, Mn and Zn contents of curly lettuce, while increasing the membrane damage index, but the physical and physiological properties and mineral content affecting the yield and quality of curly lettuce improved with increasing biochar rates. In the study, as a result of the emergence of the highest stress factor in irrigation at 33% level, it was observed that physical and physiological properties and mineral content of curly lettuce were affected at the highest level, and the dose of biochar, which managed the stress most effectively, was 3%. As a result, considering that biochar has an important potential to improve yield and quality losses of curly lettuce grown under deficit irrigation conditions, the use of biochar in the deficit irrigation regime were found to be recommendable.
Formulation and physical stability analysis of red beetroots (Beta vulgaris l.) effervescent granules
Authors: Florenly Florenly , Lokanata Shieny , Friando Jovin , Mai Phuong Thao , Le Hong Hai , Luzria Cut Cynthia , Sintapanont Anusak
Published: August 2023

ABSTRACTIntroduction: Red beetroots (Beta vulgaris L.) are a natural ingredient rich in nutrients and provide various notable health benefits. In dentistry, red beetroots have the potential to act as a plaque-disclosing agent. Previous studies showed that red beetroot preparation in gelform is more effective compared to chewable tablets, but has significant drawbacks in taste. Effervescent granules have the potential to conceal the unpleasant taste of beetroot substances. This study aims to determine the ideal formula and evaluate the physical properties and stability of effervescent granules made from red beetroot extract. Methods: This was an experimental design study with descriptive analysis. The maceration method was used to extract the red beetroot constituents. Fresh fruits were collected, air-dried, and macerated with 96% ethanol twice. The filtrates were then concentrated. The wet granulation method was used to formulate effervescent granules. The samples were grouped into formula 1 (F1), formula 2 (F2), and formula 3 (F3) using 1%, 3%, and 4% red beetroot extract, respectively. All sample groups were analyzed for physical stability, namely: organoleptic, flowability, density, dissolving time, and pH tests. Results: All samples surpassed the sensory evaluation for physical properties. Formula 1 (1%) and formula 2 (3%) models passed all the physical stability tests. Meanwhile, the 4% formula (F3) failed two physical tests. F1 (1%) samples also showed lighter brown color for its lower beetroot extract concentration, indicating under-qualification as dental plaque staining materials. Therefore, 3% concentration (F2) has the best formulation regarding physical properties and stability. Conclusion: Formulas F1 and F2 have the best physical properties and stability by passing all the tests, while Formula 3 failed the organoleptic and flow rate tests.KEYWORDSformulation, physical stability, Beta vulgaris L, effervescent granules
Valor de marca y la decisión de compra de los clientes de la marca Master Belle, Lima- Perú 2021
Authors: Montalvan Aratia Alejandra , Chirapa Romero Jazmin Cristhel
Published: August 2023

El objetivo del estudio fue establecer la relación entre el valor de marca y la decisión de compra de los clientes de la marca Master Belle Lima - Perú 2021. La investigación asumió el enfoque cuantitativo, el diseño no experimental- transeccional correlacional. Se tomó como población a los 150 clientes actualizados en la base de datos de la empresa al 2021; la muestra utilizada estuvo conformada por 109 clientes de la marca. Se utilizó el cuestionario como instrumento y se obtuvo su confiabilidad por el coeficiente de alfa de Cronbach VM. (0,718) y DC. (0,863). Los resultados indicaron una relación directa y alta entre las variables, con una Rho de Spearman (0,639). De esta manera, en los resultados se pudo evidenciar que el valor de marca se relaciona significativamente con la decisión de compra, es decir que, a mayor percepción sobre un buen desarrollo del valor de marca, mayor será la decisión de compra de los clientes hacia los productos de la marca Master Belle.
Kegiatan Psikoedukasi dan Pelatihan untuk Mengoptimalkan Karakter Tanggung Jawab Akademik pada Siswa
Authors: Wibowo Doddy Hendro , Ardhana Daniel Evan , Grenadi Kezia Margaretha , Patricia Cherenita Fonda , Agnis S Margareth Dellasja , Rahmawati Leony , Anugrah Putra Hosea Janinda , Pramisda Kezia Putri , Ruthi Abigail
Published: August 2023

Pendidikan karakter memiliki tujuan untuk mengembangkan sikap dengan tuntutan jaman yang selalu berubah. Siswa SMP dapat dikatakan telah memasuki tahap perkembangan remaja awal, dimana pada masa tersebut merupakan masa-masa peralihan menuju masa pembentukan tanggung jawab. Tujuan umum kegiatan adalah siswa mampu menerapkan sikap bertanggung jawab akademik di sekolah. Peserta Psikoedukasi yaitu siswa kelas VIII A yang berjumlah 32 siswa di SMP Kristen Satya Wacana Salatiga. Berdasarkan hasil perhitungan nilai post-test menunjukkan siswa dapat memahami tentang materi tanggung jawab dengan baik. Mereka menunjukkan sikap tanggung jawab yang variatif, baik dalam pengerjaan dan pengumpulan tugas tepat waktu maupun bertanggung jawab dalam menjalankan piket kelas. Siswa mengharapkan di lain kesempatan dapat dilakukan kegitan serupa dengan tema lain.
Book review of Stephan F. Miescher. 2022. A dam for Africa: Akosombo stories from Ghana
Authors: Singh Satyajit
Published: August 2023

 
El papel del binomio mujer-turismo ante el Covid-19: un análisis del mercadeo y desarrollo local en la Región de los Volcanes
Authors: Rodríguez-Licea Gabriela , Santiago-Rodríguez María del Rosario , Palma-Ramírez Karen Jaqueline , Tapia-Rodríguez María Zamira
Published: August 2023

Objetivo: identificar el papel que ha jugado el binomio mujer-turismo en el mercadeo y desarrollo local durante la contingencia sanitaria. Metodología: se trata de una investigación cualitativa de corte exploratorio-descriptivo en el que la población objeto de estudio se seleccionó por muestreo no probabilístico voluntario y el análisis integral se basa en los principios de la Iniciativa de Desarrollo Rural LEADER. Resultados: se aporta evidencia de que, en los Grupos de Acción Local asociados al turismo rural, la desagregación de las actividades económicas permitió que las áreas que operaron en pandemia solventaran las necesidades de las que no tuvieron apertura, generando así, un beneficio mutifuncional; además, la vinculación y colaboración público-privada a través de alianzas multisectoriales establecidas en las iniciativas de los proyectos de desarrollo, contribuyó a que se mantuvieran los servicios ecoturísticos y el comercio local, el 38% de las mujeres participaron en la toma de decisiones y en la oferta de servicios turísticos, productos agropecuarios y agroindustriales, artesanías y platillos típicos. Limitaciones: dadas las medidas de sanitarias establecidas por la Secretaría de Salud Mexiquense, no se pudo incluir a todas las mujeres que participan en las actividades turísticas de la Región de los Volcanes. Conclusiones: las estrategias de escalabilidad implementadas han fortalecido el tejido socioeconómico en la región e impulsado el desarrollo local.
Canales de búsqueda y duración del desempleo en México
Authors: Varela-LLamas Rogelio , Ocegueda-Hernández Juan Manuel
Published: August 2023

Objetivo: analizar la duración del desempleo y su relación con los canales de búsqueda en el mercado laboral de la economía mexicana durante el primer trimestre de 2018 y 2021. Metodología: con microdatos de la Encuesta Nacional de Ocupación y Empleo (ENOE), se estima un modelo probit ordenado de respuesta múltiple. Se explora cómo impactan distintos canales de búsqueda y características personales del individuo en la probabilidad de que el desempleo sea de corta, media o larga duración. Resultados: se encuentra que tener experiencia laboral facilita el proceso de inserción laboral, logrando que el periodo de desempleo sea relativamente corto. Utilizar canales de búsqueda como acudir a bolsas de trabajo o agencias privadas de colocación y acceder a programas de empleo temporal, aumenta la probabilidad de que la duración del desempleo no exceda un trimestre. Vivir en un estado de la frontera norte de México aumenta la posibilidad de que el desempleo sea de corta duración. Limitación: el trabajo no analiza la relación de interés en términos sectoriales. Conclusiones: la experiencia laboral facilita el proceso de inserción laboral y los canales de búsqueda formales permiten que el desempleo sea de corta duración. La escolaridad aumenta la probabilidad de que el desempleo no sea de larga duración.
Rätselhafte Datenpolitik
Authors:   Universität Graz, Kraemer Klaus
Published: August 2023

In the social sciences, the inadequate corona data policy of the Robert Koch Institute (RKI) and the focus on the daily or cumulative number of confirmed Covid 19 cases has been criticised, albeit only sporadically, already in spring 2020. For example, one of the leading statisticians in sociology in Germany, Rainer Schnell - together with Menno Smid of the Infas Institute for Applied Social Science - stated in unsparing clarity at the digital colloquium ‚Sociological Perspectives on the Corona Crisis‘ of the Social Science Research Center Berlin on 15 April 2020 that it was incomprehensible why the RKI would limit itself to absolute reporting incidences of those tested positive without taking into account influencing factors such as test occasions and test frequencies. The RKI also refrained from representative surveys on the incidence of infection and instead relied on unreliable survey instruments. Professional pandemic management is simply not possible without a solid database. These early cautionary recommendations went unheeded instead of shedding light on the darkness of the official data desert on the actual infection rate and individual infection risks.
DIFICULDADES ASSOCIADAS AO PREENCHIMENTO DA CADERNETA DA CRIANÇA E DO IDOSO: UMA ANÁLISE COMPARATIVA
Authors: De Lima Jessane Thifanny , Coelho Lara Beatriz de Sousa , Clementino Adson Matheus Carvalho , Lopes Marcos Paulo Silva , Reis Juliana Ferreira , Oliveira Alanys da Silva , Do Nascimento Luana Martins , Oliveira Lívia Matos , Oliveira Francisco Braz Milanez
Published: August 2023

Objetivo: examinar as evidências científicas disponíveis sobre o preenchimento das cadernetas da criança e do idoso, bem como realizar uma comparação dos principais desafios encontrados para o não preenchimento desses instrumentos de assistência. Métodos: revisão integrativa da literatura através de busca na base de dados SCIELO, GOOGLE SCHOLAR e PUBMED utilizando os descritores “Assistência de Enfermagem”, “Caderneta da criança” e “Caderneta do idoso”. Resultados: Quanto ao preenchimento das cadernetas, os resultados mostraram que a Caderneta da Criança apesar de ter um preenchimento insuficiente possui maior adesão de preenchimento pela equipe multiprofissional quando comparada ao preenchimento da caderneta de Saúde da Pessoa. Tais dificuldades, estão associadas às limitações no acesso aos serviços, carência de infraestrutura e baixa qualificação de profissionais. Por conseguinte, o enfermeiro deve estar atento ao adequado preenchimento, sendo que este possui a atribuição de atualizar e estimular a equipe a utilização. Considerações finais: Há poucas evidências sobre estudos acerca dos registros em Caderneta de Saúde da Pessoa Idosa, em contrapartida, há mais evidências sobre registros em Caderneta da Criança realizado pela equipe multiprofissional, como Agente Comunitário de Saúde, Nutricionista, Terapeuta Ocupacional, Médico, Enfermeiro, entre outras.
INTERVENÇÕES DE ENFERMAGEM FRENTE A COMPLICAÇÕES APRESENTADAS POR PACIENTES HEMODIALÍTICOS: UMA REVISÃO INTEGRATIVA
Authors: Chaves Mickael Nathan Rodrigues , Coelho Lara Beatriz Sousa , Viana Camilla Lohanny Azevedo , Vasconcelos Anailda Fontenele , De Brito Rayane Sousa , Rodrigues Irla Samara Bonfim , Da Silva Carlos Pedro Magalhães , Oliveira Francisco Braz Milanez
Published: August 2023

Objetivo: Identificar as evidências disponíveis na literatura acerca das intervenções de enfermagem frente aos cuidados diante das complicações inerentes ao tratamento hemodialítico. Metodologia: Trata-se de uma revisão integrativa da literatura através de buscas nas bases de dados PubMed; BVS e Scopus, em abril de 2023. Estabeleceu-se a pergunta norteadora: “Quais são as evidências disponíveis na literatura acerca das intervenções de enfermagem frente a complicações apresentadas por pacientes submetidos à hemodiálise?”. Foram excluídos protocolos de revisão sistemática ou meta análise e estudos incompletos, que não fazem referências ao objetivo da pesquisa. Resultados: Na busca foram selecionados 09 estudos para essa revisão, que atenderam aos critérios de elegibilidade. Foi evidenciado na literatura que a implementação de medidas preventivas específicas durante o processo de HD pode reduzir significativamente a incidência de complicações em pacientes submetidos a esse procedimento. Quanto as complicações mais frequentes em pacientes em tratamento, são elas: náuseas, cefaleia, hipotensão, cãibras, coagulação e infecções. Evidencia-se que a identificação e gerenciamento precoce dessas complicações podem melhorar os resultados clínicos e a qualidade de vida dos pacientes. Os cuidados de enfermagem como monitorização frequente dos sinais vitais, higienização adequada, administração correta de fármacos, orientações voltadas para o autocuidado, além de medidas inovadoras são importantes para garantir a segurança do paciente durante tratamento. É necessário o conhecimento dos profissionais sobre as complicações associadas à HD para que assim estejam aptos a intervir da maneira correta. Considerações finais: Os estudos mostraram que é imprescindível que os profissionais de saúde envolvidos na assistência, especialmente enfermeiros, estejam aptos para intervir em possíveis complicações durante a terapia, a fim de minimizar os impactos à saúde do paciente.
LASERACUPUNTURA PARA O TRATAMENTO DA ANSIEDADE E DEPRESSÃO NA SÍNDROME PÓS-COVID-19: RESULTADOS PROMISSORES DE UM ESTUDO QUASE-EXPERIMENTAL
Authors: Salvador Drielly Lima Valle Fôlha , Fernandes Carlos Alexandre Molena
Published: August 2023

A pandemia da COVID-19, provocou um grande impacto na saúde mental das pessoas, mesmo após a fase aguda da doença, resultando em altas taxas de ansiedade e depressão, tornando necessário o desenvolvimento e a avaliação de tratamentos, não farmacológicos, eficazes para aliviar esses sintomas. Este estudo quase-experimental, aberto, unicêntrico, realizado nos meses de fevereiro e março de 2023, no ambulatório de enfermagem da Universidade Estadual do Paraná, campus de Paranavaí, teve como objetivo avaliar a eficácia da Laseracupuntura, para o tratamento de ansiedade e depressão, na Síndrome Pós-COVID-19. O estudo foi aprovado pelo Comitê de Ética (Parecer nº. 5.262.784). Foram coletados dados demográficos, socioeconômicos e de estado de saúde. A presença e a intensidade de ansiedade e depressão foram verificadas no início e, ao final, do tratamento, por meio do Inventário de Ansiedade de Beck (21 itens) e Inventário de Depressão de Beck (21 itens). Ao todo, 23 voluntários receberam até 10 sessões, de um protocolo de Laseracupuntura, para tratar ansiedade e depressão pós-COVID-19. Os pontos P1, PC6, E36, E25, VC6, VC12, VC17 e Yintang, foram estimulados por luz de laser infravermelho sobre a pele. Os participantes eram predominantemente, mulheres, de raça/cor branca e tinham sobrepeso ou obesidade. Os sintomas pós-agudos da COVID-19, mais relatados, foram: ansiedade, queda de cabelo e dor de cabeça. A mediana inicial de pontuação das escalas de ansiedade e depressão foram de 23,00 (IQR, 13,50 – 27,50) e 22,00 (IQR, 11,50 – 26,50), respectivamente. A intervenção resultou em reduções significativas, nas pontuações de duas escalas: de ansiedade (DM = -9,74; IC 95%, 4,88 – 14,60; p < 0,001) e depressão (DM = -9,87; IC 95%; 5,53 – 14,21; p < 0,001). Nenhum efeito colateral foi relatado durante o tratamento. Os resultados obtidos neste estudo, sugerem que, a Laseracupuntura pode ser uma terapia eficaz e segura para tratar sintomas de ansiedade e depressão em pacientes pós-COVID-19. Além disso, o uso da laseracupuntura, tem a vantagem adicional de ser menos invasiva que a Acupuntura tradicional, tornando-a uma opção atraente para pessoas que buscam tratamentos integrativos para saúde mental, sem os riscos presentes em terapias medicamentosas tradicionais. Recomenda-se a realização de mais estudos – principalmente ensaios clínicos randomizados –, para confirmar a eficácia da Laseracupuntura.
Impact of COVID-19 Pandemic on Dietary Patterns and Physical Activity in Overweight and Obese Adolescents Based on Body Fat Percentages
Authors: Syukrina Fatma , Sartika Ratu Ayu Dewi , Putri Rizti Millva
Published: August 2023

Background: Obese and overweight adolescents have a high risk of COVID-19 susceptibility and severity compared to normal nutritional status. Although a healthy dietary pattern and physical activity do not entirely prevent infection, they play a substantial role in the host's response to infectious agents. The purpose of this study is to analyze the changes in dietary patterns and physical activity during the COVID-19 pandemic in overweight and obese adolescents based on body fat percentages (BFP). Method: A cross-sectional study using purposive sampling was conducted on 159 adolescents from selected high schools in West Lampung, Indonesia. Data collection was assessed using a body composition scale and Food Frequency Questionnaire (FFQ). Data analysis was performed using SPSS. The Wilcoxon signed-rank test was used to analyze the differences between the two adolescent groups. Result: The overweight and obese adolescents group increased the consumption of unhealthy foods and beverages compared to the normal group (p<0.05). Both groups significantly increased the fruit rich in vitamin C consumption (p<0.05), but no significant difference in vegetable consumption (p>0.05). Both groups were found to have no significant difference in physical activity, both before and during the COVID-19 pandemic (p>0.05). Conclusion: Adolescents with normal body fat percentages (BFP) tend to have better dietary patterns, in contrast to overweight and obese adolescents with a high BFP who tend to have a decrease in the quality of their dietary patterns. Then, both groups were found to have a significant decrease in the frequency of physical activity during the COVID-19 pandemic.
Conjugated Polymer Process Ontology and Experimental Data Repository for Organic Field-Effect Transistors
Authors: Liu Aaron , Lee Myeongyeon , Venkatesh Rahul , Bonsu Jessica , Volkovinsky Ron , Meredith Carson , Reichmanis Elsa , Grover Martha
Published: August 2023

Polymer-based semiconductors and organic electronics encapsulate a significant research thrust for informatics-driven materials development. However, device measurements are described by a complex array of design and parameter choices, many of which are sparsely reported. For example, the mobility of a polymer-based organic field-effect transistor (OFET) may vary by several orders of magnitude for a given polymer, as a plethora of parameters related to solution processing, interface design/surface treatment, thin-film deposition, post-processing, and measurement settings have a profound effect on the value of the final measurement. Incomplete contextual, experimental details hamper the availability of reusable data applicable for data-driven optimization, modeling (e.g., machine learning), and analysis of new organic devices. To curate organic device databases that contain reproducible and Findable, Accessible, Interoperable, and Reusable (FAIR) experimental data records, data ontologies that fully describe sample provenance and process history are required. However, standards for generating such process ontologies are not widely adopted for experimental materials domains. In this work, we design and implement an object-relational database for storing experimental records of OFETs. A data structure is generated by drawing on an international standard for batch process control (ISA-88) to facilitate the design. We then mobilize these representative data records, curated from literature and laboratory experiments, to enable data-driven learning of process-structure-property relationships. The work presented herein opens the door for the broader adoption of data management practices and design standards for both the organic electronics and the wider materials community.
Push-Pull and Conventional Nitriles as Halogen Bond Acceptors in their Cocrystals with Iodo-substituted Perfluorobenzenes
Authors: Toikka Yulia , Gomila Rosa , Frontera Antonio , Izotova Yulia , Kukushkin Vadim , Bokach Nadezhda
Published: August 2023

Co-crystallization of the push-pull nitriles NCNR2 (R2 = Me2 1, C4H8 2, C5H10 3, C4H8O 4) with iodo-substituted perfluorobenzenes (1,4-diiodotetrafluorobenzene – 1,4-FIB and 1,3,5-triiodotrifluorobenzene – 1,3,5-FIB), gave cocrystals 1·1,3,5-FIB, 2·1,3,5-FIB, 3·½(1,4-FIB), 4·½(1,4-FIB), and 4·2(1,3,5-FIB), which were studied by single-crystal X-ray diffractometry (XRD). The structure-directing I···sp-Nnitrile halogen bond (HaB) in all cocrystals was identified based on the consideration of the XRD geometrical (bond length and angles) parameters and also by Hirshfeld surface analysis, whereupon the observed HaBs were analyzed theoretically. The HaB accepting role of the push-pulling dialkylcyanamides NCNR2 and conventional nitriles NCR (R = Alk) was examined and compared in details using, as model examples, the structures of cocrystals 3·½(1,4-FIB) (this work) and AdCN·½(1,4-FIB) (CSD refcode: KIHROL). These two cocrystals, which display similar supramolecular organization, were studied by several quantum chemistry methods including molecular electrostatic potential (MEP) surface analysis, the natural bond orbital (NBO) analysis, the quantum theory of atoms in molecules (QTAIM) combined with and NCIPlot approach, and also by the Kitaura–Morokuma energy decomposition approach. While AdCN is slightly poorer sp-N electron donor than the push-pull nitrile 3, HaBs in the cocrystals exhibit similar interaction energies. Although in the covalent chemistry, the two types of nitriles often exhibit strikingly different reactivity patterns, the -hole based I···sp-Nnitrile noncovalent interaction provided the leveling effect resulting in significant similarities between the HaB situations for both nitrile species.
Methacrylated Kraft lignin as a double-edged sword: a quantitative analysis of Kraft lignin-containing objects printed by stereolithography
Authors: Chmely Stephen , Rohi Gal Mostafa , Arya Aditi , Lin Wei-Shu , Mendis Gamini
Published: August 2023

Finding an alternative to fossil-based resins which is renewable, sustainable, and affordable is an important step to enable large-scale industrial manufacturing using stereolithography. Lignin has shown some potential to fulfil these requirements. However, examples that contain Kraft lignin, which is produced industrially at a rate of 70 million tons per year, are relatively scarce compared to examples using organosolv lignin or lignin model compounds. In this work, we fractionated and modified Kraft lignin and blended it with a commercially available stereolithography resin produce 3D printed objects. We thoroughly characterized the lignin, the resins, and the 3D printed objects, and conclude that while our modification scheme allows for smooth incorporation of large amounts Kraft lignin into resins (up to 10% (w/w), or 10 times the amount previously demonstrated as possible), and the lignin itself aids in the photopolymerization process (Ec = 662(2) mJ·cm-2 for the base case, Ec = 0.763(1) mJ·cm-2 for resins containing 10% (w/w) lignin), the printed objects are weaker (σ = 20(1) MPa) and more brittle (ε = 1.12(5)%) than the control that contains no Kraft lignin (σ = 46.3(5) MPa, ε = 3.95(9)%). Together, these results demonstrate the importance of lignin modifications to create miscible blends for stereolithography resins but highlight the need for further understanding how these modifications can simultaneously enhance photo- and mechanical properties of printed objects. These are an important first step towards creating 3D printable objects that contain industrially relevant lignin.
How robust is the ligand binding transition state?
Authors: Bose Samik , Lotz Samuel , Deb Indrajit , Shuck Megan , Lee Kin Sing Stephen , Dickson Alex
Published: August 2023

For many drug targets, it has been shown that the kinetics of drug binding (e.g. on rate and off rate) is more predictive of drug efficacy than thermodynamic quantities alone. This motivates the development of predictive computational models that can be used to optimize compounds on the basis of their kinetics. The structural details underpinning these computational models are not only found in the bound state, but also in the short-lived ligand binding transition state: the highest free energy point along the (un)binding pathway. Although this transition state cannot be directly observed experimentally, due to its extremely short lifetime, recent successes have demonstrated that modeling of the ligand binding transition state is possible with the help of enhanced sampling methods for molecular dynamics. In our previous work we analyzed the transition state ensemble for an inhibitor of soluble epoxide hydrolase (sEH) with a residence time of 11 minutes. Here we computationally modeled unbinding events for five additional inhibitors of sEH with residence times ranging from 14.25 to 31.75 minutes, with our results recapitulating these experimental residence times to within an order of magnitude. The unbinding ensembles are analyzed in detail, focusing on features of the ligand binding transition state. We find that ligands with similar structures and similar bound poses can show significant differences in their ligand binding transition states, in terms of their spatial location and their interactions with specific protein residues. However we also find similarities across the transition state ensembles when examining more general features such as ligand degrees of freedom. Together these findings show significant challenges for rational, kinetics-based drug design.
Neuroprotective effects of hepatoma-derived growth factor in models of Huntington’s disease
Authors: Voelkl Kerstin , Gutiérrez-Ángel Sara , Keeling Sophie , Koyuncu Seda , da Silva Padilha Miguel , Feigenbutz Dennis , Arzberger Thomas , Vilchez David , Klein Rüdiger , Dudanova Irina
Published: August 2023

Huntington’s disease (HD) is a movement disorder caused by a mutation in the Huntingtin gene that leads to severe neurodegeneration. Molecular mechanisms of HD are not sufficiently understood, and no cure is currently available. Here, we demonstrate neuroprotective effects of hepatoma-derived growth factor (HDGF) in cellular and mouse HD models. We show that HD-vulnerable neurons in the striatum and cortex express lower levels of HDGF than resistant ones. Moreover, lack of endogenous HDGF exacerbated motor impairments and reduced the life span of R6/2 Huntington’s disease mice. AAV-mediated delivery of HDGF into the brain reduced mutant Huntingtin inclusion load, but had no significant effect on motor behavior or life span. Interestingly, both nuclear and cytoplasmic versions of HDGF were efficient in rescuing mutant Huntingtin toxicity in cellular HD models. Moreover, extracellular application of recombinant HDGF improved viability of mutant Huntingtin-expressing primary neurons and reduced mutant Huntingtin aggregation in neural progenitor cells differentiated from human patient-derived induced pluripotent stem cells. Our findings provide new insights into the pathomechanisms of HD and demonstrate neuroprotective potential of HDGF in neurodegeneration.
Experimental Images of Labour, Aotearoa New Zealand, 1974-2023
Authors:   , Thompson Christopher
Published: August 2023

This research critically analyses representations of labour in the experimental films of Aotearoa New Zealand from the 1970s, when such filmmaking gained prominence, to the present time of writing, 2023. Specifically, I explore representations of agricultural and industrial work, feminist and Indigenous aesthetics, and images of immaterial labour that have emerged in response to social, cultural, technological and political transformations. To the detriment of cinema culture, experimental film has received limited and intermittent recognition, funding, and screening opportunities. A comprehensive history of Aotearoa’s experimental film history does not yet exist, and academic scholarship on the topic is scarce. This research aims to address this historical neglect by foregrounding experimental cinema as a distinct and vital category within the broader cinematic landscape. This thesis deploys a combination of Marxist and post-Marxist theories to analyse the many paradoxes of global capitalism. Marxism enables a critique of capitalism, provides a lens for analysing capital’s effects on labour and cinema, and proves useful when analysing the aesthetic dimensions of the experimental image. In addition to the theoretical exploration, this research incorporates two original experimental films that contribute to the ongoing discussions as well as advance new aesthetic means of representing labour. This research underscores the complexity and evolving nature of labour and its critical representation within experimental cinema. It shows that New Zealand experimental film has explicated labour’s role in shaping subjectivity, made visible labour’s role in perpetuating settler colonial ideologies, and emphasised the vitality of minority voices. As an art practice that exists outside of, and sometimes even in opposition to, dominant ideologies, experimental cinema’s representation of labour is crucial to understanding fundamental intersections between art, politics, and culture in Aotearoa New Zealand.
Effective diffusivity determination of date (Phoenix dactylifera L.) leather in infrared drying: Effect of cooking time
Authors: TİREKİ Suzan
Published: August 2023

Longer process times in conventional drying methods can be improved by using rapid technologies. Infrared drying is one of these faster methods. Consumer awareness on health and wellness products has increased and boosted with Covid-19 pandemic. Therefore, consumption trend of snack products formulated with natural ingredients has increased. It is estimated that this trend will continue to rise. In accordance with this, fruit leather production from dates was done by infrared drying and effect of cooking time on drying behavior was investigated. Firstly, dates were washed and seeds were removed, then water was added at a ratio of 1:2.5 (dates:water), and cooked for 30, 45 and 60 min. Samples were pressed and dried at 10 mm thickness. Drying curves showed first order drying kinetics and effective moisture diffusivity (Deff) of fruit leathers were found as 1.5283×10-9, 1.6971×10-9 and 1.7351×10-9 m2/s for 30, 45 and 60 min of cooking time, respectively.
Küçükçekmece Lagünü'nün Çevre Manyetizması: Son 3900 yıl boyunca paleo-ortam değişimleri
Authors: Makaroglu Özlem
Published: August 2023

Bu çalışmada, günümüzden önce (GÖ) 3900 yıl boyunca, Marmara Denizi’nin kuzeyinde yer alan, Küçükçekmece Lagünü’nde depolanan sedimanlarda manyetik mineraloji, mineral yoğunluğu ve tane boyu değişimleri belirlenerek lagünün paleo-ortam koşulları incelenmiştir. Bu amaçla, Küçükçekmece Lagünü’nün 20 ve 17 m. derinliğinden alınan üç adet karotta (KCL12P1, KCL12P2, KCL12P3) manyetik duyarlılık (κLF), kalıntı mıknatıslanma (anhisteretik ve eş -ısıl) şiddetleri ve termomanyetik ölçümleri içeren yüksek çözünürlükte manyetik mineral analizleri yapılmıştır. Manyetik mineral analizleri ve litolojik gözlemlere göre, lagün sedimanlarında üç farklı birim (birim A, B ve C) tanımlanmıştır. Birim A; düşük manyetik duyarlılığa sahip, düşük yoğunlukta ince tane boylu ferrimanyetik (manyetit) minerallerle birlikte çoğunlukla detritik kökenli paramanyetikler minerallerce (siderit) baskın bir birimdir. Birim B; yüksek manyetik duyarlılık, kalıntı mıknatıslanma değerleri ve termomanyetik analizlerle kolayca ayırt edilen, demir sülfür (greigit) içeriği yüksek olan bir birimdir. Birim C ise kaba taneli ve yüksek koersiviteye sahip ferrimanyetik minerallerce baskın bir birim olarak tanımlanmıştır. Küçükçekmece Lagünü-nün çevre manyetizmasına göre, birim A GÖ 3750-3700, 3600-3350, 3240-1800, 1240-günümüz arasında görece yağmurlu; birim B ve C ise GÖ 3883-3750, 3700-3600, 3350-3240, 1800-1240 yılları arasında kurak iklim koşullarının hâkim olduğu dönemlerde oluşmuştur. Lagünde her kurak dönemin sonuna doğru GÖ 3780-3750, 3620-3600, 3300-3240 ve 1300-1240 yılları arasında, greigit mineralinin yoğunlaştığı birim B oluşmuştur. Bu sonuç, nehir girdisinin azalmasıyla beraber, lagünde Marmara Deniz sularının yoğunlaştığı koşulları desteklemektedir.
Determination of Structural and Optical Properties of Zn1-xCuxO Nanoparticles by Chemical Bath Deposition Waste Recovery Technique
Authors: Yakar Emin
Published: August 2023

In this work, Zn1-xCuxO nanoparticles (x= 0.025, x=0.050, and x=0.075) were synthesized by co-precipitation technique using chemical bath deposition wastes of Cu:ZnO thin films. The XRD evaluation showed that the well-crystalline hexagonal wurtzite ZnO indexed peaks. Average crystallite sizes were found to be around 35.6-42.9 nm range by using the Debye-Scherrer equation. Surface morphology results showed that dense layer of nano-roses and fewer nanorods formations in low Cu-concentrated (x=0.025 and x=0.050) samples. The optical absorption edge shifted slightly to the higher wavelength from 350 nm to 375 nm with decreasing copper concentration, as mentioned the blue shift. Blue shift might be caused an increase in the optical band gap from 3.14 eV to 3.28 eV due to the decrease in Cu concentration.
Removal of foreign objects seen in the upper gastrointestinal tract with the help of endoscopy: A retrospective cohort study
Authors: Çalta Alpaslan Fedayi
Published: August 2023

Background/Aim: Delay in diagnosing and treating gastrointestinal (GI) tract foreign bodies may lead to serious complications. In this study, we aimed to retrospectively evaluate the patients who underwent emergency upper GI endoscopy for foreign body ingestion in our clinic.
Methods: Between 2015 and 2022, we evaluated 68 patients who underwent emergency upper GI endoscopy with a prediagnosis of foreign body ingestion. The evaluation included factors such as age, gender, presenting complaints, foreign body type, localization, and treatment parameters.
Results: Out of the 68 patients included in the study, 21 (30.89%) were female, and the mean age was 54.00 years. Among them, 43 (63.23%) presented with no active complaints, 23 (33.82%) with dysphagia and odynophagia, and two (2.94%) with vomiting. The swallowed objects were classified as follows: coin (n=2), pin (n=5), battery (n=11), drug plaque (n=6), esophageal foreign body (n=7), piece of meat (n=5), chicken bone (n=4), fish bone (n=5), razor (n=7), lighter (n=3), and toothpick (n=1). The foreign bodies were located in the esophagus in 23 cases (33.82%), in the stomach in 32 cases (47.05%), and in the duodenum in one case (1.47%). For 12 patients (17.64%), the foreign body could not be detected endoscopically but was detected using radiologic methods. Among the foreign bodies, 54 (79.41%) were successfully removed. In one patient (1.47%) who could not be removed endoscopically and another patient (1.47%) who developed gastrointestinal perforation due to a foreign body (toothpick), a surgical procedure was performed.
Conclusion: Early diagnosis and treatment of foreign body ingestion are crucial in preventing serious complications. Endoscopy, a minimally invasive procedure, can be a safe alternative to surgical procedures, which may carry higher morbidity and mortality risks.
Numerical Analysis and Parametric Study on Multiple Degrees-of-Freedom Frames
Authors: Alaneme George U. , Bahrami Alireza , Ibe Iro Uzoma , Ganasen Nakkeeran , Otu Obeten N. , Udeala Richard C. , Ifebude Blessing O. , Onwusereaka Emmanuel A.
Published: August 2023

The design of multiple degrees-of-freedom frames is critical in civil engineering, as these structures are commonly used in various applications such as buildings, bridges, and industrial structures. In this study, a six-degrees-of-freedom beam-column element stiffness matrix was formulated by superposition of beam and truss elements stiffness matrices and was adapted to statically analyze indeterminate frame structures. The development of a numerical model for the frame structures was achieved using the finite element method in the current study. Also, the investigation of the effects of various parameters such as frame geometries, material properties, and loading conditions was conducted on the internal forces developed in the frame structures. Three different parametric study cases that presented the frame structures with varying geometries and loading conditions were analyzed utilizing this matrix approach for the sake of emphasis and to evaluate the flexibility and adequacy of this formula to analyze the indeterminate frames using the MATLAB software. The analysis method comprised the derivation of the system displacements employing the relationships between the stiffness matrix and fixed end forces as the force vector and taking the attained displacements, which would be transformed to the local coordinates to obtain the member forces. The computed results from the element stiffness matrix approach were further statistically compared with the results achieved from the finite element software (SAP2000) applying the analysis of variance (ANOVA). The statistical results showed a P-value > 0.05, which indicated a good correlation between the compared results and adequate performance for the derived beam-column element matrix formula method. Doi: 10.28991/CEJ-2023-09-07-012 Full Text: PDF
Determinant Factors of Corporate Social Responsibility Disclosures in Hospitality and Tourism Companies in Indonesia and Thailand
Authors: Hatane Saarce Elsye , Chandra Jennifer Eugene , Purnamawati I Gusti Ayu , Semuel Hatane
Published: August 2023

Corporate Social Responsibility (CSR) is increasingly recognized as one aspect of sustainable business development. Within the tourism industry, CSR plays an important aspect in integrating social and environmental concerns in strategies, policies, and business operations in interactions with the community and the company’s stakeholders. This study aims to assess and examine the critical factors that influence the formation of Corporate Social Responsibility Disclosure (CSRD) in hospitality and tourism sector companies. The motivation for this research stems from previous studies that showed contradictory results regarding the factors that influence CSRD. Furthermore, research on the factors that influence CSRD in Indonesia and Thailand’s hospitality and tourism industries is rarely done. This study uses company data from 2015 to 2019 with the Generalized Least Square and Weighted Least Square methods in data analysis. This study examines the effect of Profitability, Leverage, Firm Value, Liquidity, and Firm Size on CSRD. In addition, this study contributes to research on the influence of Firm Value on CSRD, which is still rarely done. This study shows that Leverage and Firm Size have a significant positive effect on CSRD, while Firm Value has a significant negative impact on CSRD.
Joint Impact of Financial Performance and Corporate Social Responsibility on Firm Value: Does Legitimacy Matter?
Authors: Daromes Fransiskus Eduardus , Ng Suwandi , Legaspi Korina P.
Published: August 2023

The purpose of this study is to examine the effect of the interaction of financial performance and corporate social responsibility disclosure on firm value. The research model was constructed from the theory of legitimacy and used a purposive sampling method. The companies in the sample were non-financial companies listed on the Indonesian Stock Exchange for the period 2017-2019 that disclose annual and sustainable development reports respectively. Analysis of data by moderate regression analysis. The results of this study indicated that neither financial performance nor corporate social responsibility had a significant effect on firm value. On the other hand, the interaction between financial performance and disclosure of corporate social responsibility had a significant positive effect on firm value. Furthermore, the implications of the research both theoretically and practically have been discussed.
Analisis Efisiensi Usaha Pembesaran Ikan Nila di Desa Marga Sakti Kecamatan Padang Jaya Kabupaten Bengkulu Utara
Authors: Cahyati Ainun , Yuristia Rahmi , Sumantri Bambang
Published: August 2023

North Bengkulu Regency is one of the freshwater fishery producing areas in Indonesia  Bengkulu Province. Forty percent of Bengkulu Province's total freshwater fish production  is from North Bengkulu. The fishery center in North Bengkulu is in the District of  Padang Jaya and has been designated as a freshwater fishery Minapolitan area. Type  Tilapia (Oreochromis niloticus) is one type of fish that is in great demand  by the community to be cultivated, because Tilapia has sufficient tolerance  high relative to the environment as well as its relatively fast growth. Purpose  This research is: (1) Analyzing the amount of business income Tilapia  and, (2) Analyzing the efficiency level of Tilapia rearing business. Determination of the location in  this research was conducted intentionally (purposive). The population in this field study is  tilapia farmers totaling 150 farmers. Determination of the number of respondents in the field study  This is the Simple Random Sampling method. The average value of Tilapia fish production in  Marga Sakti Village is 1.817 Kg/MT so that the total revenue received by farmers  Tilapia an average of Rp. 33.608.333/ MT and the value of fish farmers' income  The average tilapia in Marga Sakti Village is Rp. 18,192,229/MT. So that the value of  The average R/C ratio per stocking season is 2.28. This shows that the effort  Tilapia cultivation with a calm water pond system in Marga Sakti Village is categorized as suitable for cultivation  cultivated because the amount of expenditure on cultivation business costs is smaller than  with acceptance.
Distribusi Pupuk Non Subsidi Pada PT Sang Hyang Seri (PERSERO) Bengkulu Marketing Branch Office
Authors: Nurbaiti Meri , Yuristia Rahmi , Badrudin Redy
Published: August 2023

Agriculture as a vital role in the Indonesian economy in meeting all the basic needs of the community requires supporting factors in the production process. Fertilizers have an important role in increasing agricultural productivity, so it is necessary to distribute fertilizers evenly throughout the region. PT Sang Hyang Seri (Persero) Bengkulu marketing branch office is a subsidiary of a state-owned company that is a distributor of non-subsidized fertilizers in the Bengkulu region. This research was conducted using data tabulation and table matrix methods with data obtained from observations and interviews. This research shows that PT Sang Hyang Seri (Persero) Bengkulu marketing branch office distributes three types of non-subsidized fertilizers in the form of SP-18 Bintang Kuda Laut, KCl Ex Belarus, and NPK Jatiwangi with two marketing alternatives, which are directly to farmers and through kiosk intermediaries. In addition, in its distribution there are five obstacles experienced, namely, 1) price competition; 2) uncertain availability of non-subsidized fertilizer stocks; 3) farmers' purchasing decisions; 4) still lack of maximum promotion; and 5) still lack of human resources.
EVALUASI OBJEK KAWASAN WISATA RELIGI (STUDI KASUS DESA BEURINGEN DAN DESA KUTA KRUENG ACEH UTARA)
Authors: Zacky Zulfan , Suparwoko Suparwoko , Iskandar Iskandar
Published: August 2023

Wisata merupakan objek yang melatar belakangi manusia untuk berkunjung pada sebuah tempat tertentu. Salah satu kategori wisata yang erat kaitannya dengan agama dan prinsip-prinsip keagamaan yang dianut masyarakat adalah wisata religi. Salah satu tempat wisata andalan di Kabupaten Aceh Utara dan tempat wisata religi adalah Kerajaan Samudra Pasai. Terdapat banyak kekurangan dalam fasilitas baik dari kebutuhan pengelola hingga para wisatawan, sebagai objek wisata religi telah memiliki potensi yang cukup dan regulasi yang jelas. Mengenai Permasalahan tersebut bagaimanan kesiapan dan fasilitas yang harus di penuhi oleh kawasan wisata religi di Desa beuringen dan Kuta Krueng. Tujuan penelitian ini untuk menganalisis kompenen objek wisata religi di kawasan Desa Beuringen dan Kuta Krueng serta mengetahui fasilitas-fasilitas yang harus dilengkapi pada wisata religi. Dalam penelitian ini, peneliti melakukan metode penelitian kualititatif deskriptif dan berbagai metode pengumpulan data. Penelitian ditemukan kebutuhan pengunjung berdasarkan fasilitas yang digunakan, kebutuhan yang tidak tersedia dan kebutuhan yang diharapkan akan tersedia.
ANALISIS KENYAMANAN TERMAL TERHADAP RUMAH TRADISIONAL ACEH
Authors: Maulinda Maulinda
Published: August 2023

Rumah merupakan salah satu tempat ternyaman yang ingin ditinggal oleh penggunanya, karena rumah merupakan tempat peristirahatan setelah melakukan kegiatan di luar rumah. Maka penggunanya pasti menginginkan suasana rumah yang dapat memberikan kenyamanan ‘termal’ ketika berada di dalam bangunan. Untuk mengetahui menggunakan parameter suhu udara, kelembaban, kecepatan angin, radiasi udara, insulasi pakaian, dan metabolic rate yang diperlukan penelitian untuk mengetahui bagaimana kenyamanan termal pada rumah adat Aceh. Penelitian ini bertujuan untuk mengevaluasi pengaruh material terhadap tingkat kenyamanan termal pada rumah tradisional Aceh beratap rumbia dan seng dengan menggunakan metode Predicted Mean Vote (PMV) dan Predicted Percentage of Dissatisfied (PPD), standar SNI, serta melakukan wawancara dengan pemilik rumah untuk mengetahui bagaimana kenyamanan termal tersebut. Hasil analisis kenyamanan termal pada rumah Aceh beratap rumbia menunjukkan bahwa nilai PMV (-0.01)~(-0.49), nilainya berada pada kategori netral dengan nilai PPD berkisar antara 5%~10%. Nilai PMV untuk rumah Aceh beratap seng berkisar antara 0.44~0.96 yang dikategorikan sedikit hangat dengan nilai PPD berkisar antara 11%~40%. Hasil standar SNI  suhu udara dan kecepatan angin pada rumah Aceh atap rumbia memiliki nilai yang sudah memenuhi, kecuali pada kelembaban memiliki nilai yang tidak sesuai dengan standar. Sedangkan rumah material atap seng untuk parameter kelembaban dan kecepatan angin tidak memenuhi standar SNI 03-6572-2001, kecuali suhu udara  yang memiliki nilai  yang memenuhi standar. Hasil wawancara kenyamanan termal pagi pengguna menjelaskan bahwa pemilik rumah hanya merasa nyaman berada di rumah adat Aceh beratap rumbia. Hasil PMV, PPD dan wawancara menunjukkan bahwa kondisi kenyamanan termal pada rumah adat Aceh beratap rumbia nyaman untuk digunakan beraktivitas dibandingkan rumah Aceh beratap seng, sehingga perlu pendingin buatan.