bluuebunny/crossref_metadata_2025 huggingface dataset:
Measurement of Supply Chain Performance by Using Supply Chain Operation Reference Based on Analytical Hierarchy Process
Authors: Mursyid Muhammad Saadillah , Wahyuni Hana Catur
Published: March 2020

This study uses the Supply Chain Operation Reference (SCOR) and Analytical Hierarchy Process(AHP) methods. From the result of research using Supply Chain Operation Reference (SCOR) method and Analytical Hierarchy Process (AHP) produced 27 KPI where for plan perspective there are 4 KPI consisting of reliability 2 KPI, responsiveness 2 KPI. For a source perspective there are 8 KPI consisting of reliability 4 KPI, responsiveness 2 KPI, Flexibility 2 KPI. Make perspective there are 7 KPI consisting of reliability 3 KPI, responsiveness 2 KPI, flexibility 2 KPI. For a delivery perspective there are 5 KPIs that consist of 3 KPI reliability, 2 KPI responsiveness. Then for the return perspective there are 4 KPI consisting of 2 KPI reliability, 2 KPI responsiveness. Then with the Analytical Hierarchy Process (AHP) method produced a delivery perspective is the perspective with the highest level of importance on the supply chain performance of PT. MSM. With the results of this performance measurement can be used as a benchmark for the company to get optimal performance.
Systematic analysis of the dominant types of entomophages in fruit orchards
Authors: Rаkhmanova М.К. , Khamdamov К.Q. , U.Rasulova  , G.Turdiyeva  , G.Rahmonova  , R.Saliyeva
Published: March 2020

Abstract: The formation of entomophauna in orchards and their  development has a great importance, and it greatly influences to the number of phitofags. During our observations of entomophages orchard in agrobiocenosis  indentified  24 dominant types which belong to seven families. Moveover, researches of entomophages show 24 dominant types which belong to 7 families. Besides that we have analysed the share of entomophage varieties concerning the entomophages.
Investigation of the influence of various chemical substances on the field of natural damage to the cold disease of the autumn wheat.
Authors: Aliyev Shavvoz , Musaeva Gulbahor
Published: March 2020

It is reported that yellow rust in the winter wheat is the most dangerous disease in the Ferghana Valley and is widespread in high humidity conditions. In recent years, the disease has spread to the irrigated grain fields of the Republic, which has significantly affected the quality and quantity of grain grown and its effective fungicidal effect.
Language teaching and testing - a research of using literature forms in the English Language Schoolbooks
Authors: Jovanovska Sashka
Published: March 2020

The use of literature forms in the English language teaching schoolbooks is enjoying a revival for a number of reasons. Having formed part of traditional language teaching approaches, literature became less popular when language teaching and learning started to focus on the functional use of language. However, the role of literature forms in the English language teaching schoolbooks has been re-assessed and many now view literary texts as providing rich linguistic input, effective stimuli for students to express themselves in other languages and a potential source of learner motivation. The aim of my thesis is to find out if in the English schoolbooks used in some schools set by experts. Although the studies on the use of literature forms in teaching English have been increasing abroad, in our country, particularly in public schools, only English grammar is being taught. The students who are expected to memorize these rules cannot use English. The aim of this seminar paper is to exhibit why and how literature forms can be used in order to teach English effectively and efficiently. I have also compared two schoolbooks (Project 2 and Dream team 3) to see the differences between the literary content.
The concept of tolerance in Islam and mysticism
Authors: Tursunovna Sharipova Oygul
Published: March 2020

This article analyzes the issues of tolerance in Islamic teachings and the Sufi doctrine, which is an important part of it. It also outlines the religious-philosophical and educational aspects of the concept of tolerance. The results will be mentioned for the further discussions.
The Effects of Colors on The Human Mind in The Interior Design
Authors: I. R.Ibadullaev  , S.B. Atoshov
Published: March 2020

This article discusses the types of colors, the colors in the interior of design, the color effects, and the negative and positive aspects of the color in the interiors
Lexico-semantic features of ecological terms connected with water
Authors: Z.Djurabaeva
Published: March 2020

The article deals with the lexical units and their lexical-semantic features associated with the concept "water". On this case, research has been mentioned on different points of the lexico-semantic features of ecological terms connected with water. It concludes with the outcomes and shortcomings as the whole.
On the Need And Ways of Converting Some of the Components of Goodwill Into Identifiable Intangible Assets
Authors: M.E.Pulatov
Published: March 2020

This article justifies the need and ways to transfer some types of exclusive rights from goodwill to identifiable intangible assets. On this way, case of national accounting system and theoretical background of the topic were discussed. Moreover, practical issues and literature review of the different point mentioned on the methodology. Finally, research concludes major points in order to make further development as the whole.
Resourse-saving technology
Authors: N.A.Mamadjonova
Published: March 2020

In agriculture, special attention should be paid to reducing the cost of the product using innovative technologies that minimize the cost of fertilizers, fuels, and lubricants, mechanization services for the placement of fertile varieties in conditions of appropriate soil and climate based on  the integration of science, education and practice.
Current status of plant resources in the Ferghana Valley and opportunities to use them
Authors: M.R. Kholikulov
Published: March 2020

In  the southern part of  Kurama mountains of  North Fergana near Havasay, Chadaksay and Rezaksay  on   the  relatively large areas of medicinal plants found  Eremurus sogdiana, Perovskija scrophulariifolia and other species.  And Ferula tenuisecta,  Prangos pabularia, Ligularia alpigena, Lagotis korolkovii, Festuca valesiaca and others meet  on  the Angren plateau
Geoecological issues of horticulture development in the foothills of the Namangan region of the Republic of Uzbekistan
Authors: Koriev Mirzohid Rustamjonovich
Published: March 2020

This article describes the possibilities of achieving economic efficiency and environmental stability through the development of horticulture in the foothills of the Namangan region. Also discussed are the features of the spread of the formed geoecological problems caused by irrigation farming and the methods of their prevention.
The Logical Theory of Evidence-Based Interpretation (scientific source analysis)
Authors: Z.A. Ilkhomov
Published: March 2020

Today the greatest role in historical processes is played by sources and their data, and also at the logical scientific conclusions which based on drawn sources with the corresponding purposes. This  article shows the basic points of view in the field of methodology of historical science and work with sources in historical researches and on the basis of interpretation of the facts logically suitable opinions on the given question are stated.
Project management in business activity of the enterprise and its role in innovations
Authors: Akhmedova A.T
Published: March 2020

The article is devoted to the issues of interaction between project and innovation management, issues of innovative activity of the organization, problems and ways to solve them
Innovative ways of improving excursion service around the touristic destinations
Authors: Davronov I.O
Published: March 2020

Tourism is one of the leading income-generating industries. A great deal of work is being done in our country in this area. One of the main tourism services is excursion service. The tourist, first of all, wants to get acquainted with its history, culture, social life, natural resources. The excursion influences the appearance of the human spirit with its expressiveness, richness, profitability and emotionality. Tourist who comes in the country firstly wants to know and watch its history, culture, social life, natural resources. Excursion effects to people’s taking shape of their spiritual appearance with its illustrative, meaningfulness and profitableness
Theoretical aspects of the phenomenon of responsibility in interpersonal relationships
Authors: V.M. Halimova.
Published: March 2020

This article provides information on the responsibility of interpersonal relations in entrepreneurial activity. Today, the issue of responsibility is relevant for all industries. In this article, responsibility for entrepreneurship is seen as a key factor. Every modern entrepreneur needs personal responsibility, the development of this responsibility should be based on theoretical foundations.
Concepts of entrepreneurship using a psychological perspective
Authors: Khalimova Mashraboy Vohidovna
Published: March 2020

In this review of the psychology of entrepreneurship, we first present meta-analytical data showing that aspects of personality such as (overall) self-efficacy and the need for achievement, as well as entrepreneurial orientation, are closely related to entrepreneurship (business creation and business success). We then discuss the constructs that have been developed in entrepreneurship research, such as entrepreneurship vigilance, business planning, financial capital as resources, and entrepreneurial orientation, and how they can be better understood if one takes a psychological perspective. Next, we will look at how traditional psychological constructs are used in entrepreneurship and how this can improve our knowledge of industrial and organizational psychology (for example, in terms of knowledge, practical intelligence, cognitive biases, goals and visions, personal initiative, passion, and both positive and negative affect). Finally, we provide a General framework useful for the psychology of entrepreneurship, and implications for future research.
A framework for nursing participation in health policy making: a systematic review
Authors: Hajizadeh Alireza , Zamanzadeh Vahid , Kakemam Edris , Bahreini Rona , Khodayari-Zarnaq rahim
Published: March 2020

Background : Nurses as the majority of the health care workforce help in the health systems strengthening. Nurses' involvement in health policy making is clear; however, still few are involved in policy-making processes, even in the clinical context. The aim of the present systematic review was to designing a framework for nursing participation in health policy making. Methods: The present systematic review was designed on studies conducted between 2000 and 2019. Four online databases including PubMed, EMBASE, SCOPUS and Science Direct were searched using comprehensive terms. Study selection, quality assessment, data extraction, and data analysis were independently done by two reviewers. Inclusion criteria included published studies in English language and between 2000 to 2019, participants such as nurses and the healthcare managers, mentioned influential factors, types of participants were included nurses and the healthcare managers, study designs and methods clearly defined. The methodological quality of included article was appraised using the checklists of CASP and MMAT. Finally, the data were analyzed using content analysis. Results: After quality assessment, 11 studies, according to inclusion criteria, were retrieved. Nine studies had a good, two a medium, and non-articles was poor methodological quality. Three main identified themes were: nursing-related factors (4 sub- themes), management and organizational factors (8 sub-themes) and creating a positive work environment (3 sub-themes). Conclusion: The designed framework in the present review can act as a facilitator of developing more participation on behalf of nursing staff in the processes of policy making about health systems. Nurses can utilize this finding to develop empowering programs to play efficient roles and increase their participation in health policy making. Further studies are required to survey the relation between these factors and nursing participation in health policy making.
A pilot cluster randomised trial of an evidence-based intervention to reduce avoidable hospital admissions in nursing home residents (Better Health in Residents of Care Homes with Nursing - BHiRCH-NH study)
Authors: Sampson Elizabeth , Feast Alexandra , Blighe Alan , Froggatt Katherine , Hunter Rachael , Marston Louise , McCormack Brendan , Nurock Shirley , Panca Monica , Powell Catherine , Rait Greta , Robinson Louise , Woodward-Carlton Barbara , Young John , Downs Murna
Published: March 2020

Background: Nursing home residents are often frail and most have complex healthcare needs. Hospitalisation is distressing to the person, their family and nursing home staff and costly for health services. Early detection of changes in residents’ health may reduce admissions. Our aim was to pilot a complex intervention with implementation support to improve early detection and treatment for four common Ambulatory Care Sensitive Conditions (ACSCs); urinary tract and respiratory infections, chronic heart failure and dehydration. Methods: Pilot cluster randomised controlled trial in 14 nursing homes (7 intervention, 7 control). The intervention involved 1) “stop and watch (S&W)” early warning tool for changes in physical health, 2) condition- specific care pathways and 3) Situation, Background, Assessment and Recommendation (SBAR) to structure communication with primary care. of Intervention implementation was supported by Practice Development Champions (PDCs) in the care home, a Practice Development Support Group (PDSG) and regular telephone coaching with external facilitators. We collected data on nursing homes (quality ratings, size, ownership), residents, their family carers and staff demographics during the month prior to intervention and subsequently, numbers of admissions, accident and emergency visits and unscheduled GP visits monthly for 6 months during the intervention period. We collected data on how the intervention was used, healthcare resource use and quality of life data for economic evaluation. We assessed participant recruitment and retention and whether a full trial was warranted. Results: We recruited 14 nursing homes, 148 staff, 95 family carers and 245 residents. One nursing home closed prior to the intervention starting and another withdrew during the data collection phase. We retained the majority of participants recruited (95%). 15% of residents had an unplanned hospital admission for one of the four study conditions during follow-up. We were able to collect sufficient data on study questionnaires (all were over 96% complete). No home implemented intervention tools as planned. Only 16 S&W forms and 8 Care Pathways were completed. There was no evidence that the intervention was harmful.Conclusions: Study recruitment, retention, data collection and processes were effective but the intervention was not implemented in practice, therefore a full trial is not warranted. Trial registration: ISRCTN74109734 (registered 6/11/2017) https://doi.org/10.1186/ISRCTN74109734
Genetic structure and vector competence for DENV-2 of Aedes albopictus (Diptera: Culicidae) populations in China
Authors: Wei Yong , Wang Jiatian , Deng Shengqun , Fan Peiyang , He Yulan , Hu Ke , Chen Yulan , Yu Xinyi , Wang Yiwei , Zhou Guofa , Zhong Daibin , Zheng Xueli
Published: March 2020

Background: As a vector of over 20 arboviruses, Aedes albopictus has spread throughout the world mostly since the second half of the twentieth century, and it is now found on every continent except Antarctica. Approximately 50-100 million people are infected with dengue virus (DENV) transmitted by Aedes mosquitoes each year, leading to a heavy economic burden on both governments and individuals. Understanding the population genetics and vector competence of vector species is critical to effectively preventing and controlling vector-borne diseases. The aim of this study was to examine the genetic structure and vector competence for dengue virus type 2 (DENV-2) of Ae. albopictus populations across China and their relationship.Methods: From July to September in 2019, Ae. albopictus eggs were collected by using ovitraps in 8 localities across China and reared to adults in laboratory. The mitochondrial gene cytochrome c oxidase subunit 1 (cox1) were used to examine the patterns of genetic diversity and population structure among native Ae. albopictus populations. The vector competence was detected by quantitative analysis of DENV-2 virus titer in mosquito tissues (midguts, heads and salivary glands) through qRT-PCR. The correlation between population genetic indices and DENV-2 loads in the mosquitoes’ tissues was also examined.Results: A total of 20 haplotypes of mtDNA cytochrome c oxidase subunit 1 (cox1) were identified in the 120 specimens from the eight tested populations. The dominate haplotype H01 was detected in seven geographic populations of mainland China. Genetic parameters such as haplotype diversity (Hd), nucleotide diversity (π), and fixation index (FST) revealed the population diversity decreasing from south to north, and low population genetic differentiation. STRUCTURE analysis indicated that Ae. albopictus populations in southern China were clustered. In addition, The Mantel test indicated a positive correlation between genetic distance and geographical distance (R2 = 0.364, P = 0.003). We observed no correlation between population genetic indices of cox1 in Ae. albopictus populations and DENV-2 virus loads. However, the southern populations had the low DENV-2 virus loads generally.Conclusion: Conventional genetic markers such as cox1 may not reflect genetic differences in mosquitoes’ vector competence in different regions. The fact of lower DENV-2 loads in southern populations may be associated with the stable immunity system established in mosquitoes due to the long-term prevalence of dengue disease in these areas. The genetic structure and vector competence of Ae. albopictus populations in this study may have implications for understanding the epidemiology, prevention and control of vector-borne diseases.
Repeat Administration of Reversal Agents in Patients Receiving Neostigmine or Sugammadex: A Retrospective Observational Study
Authors: Gilbertson Laura , Wolf Francis , Lynde Grant C.
Published: March 2020

Background: Antagonism of neuromuscular blockade (NMB) induced by rocuronium and vecuronium can be achieved with either neostigmine or sugammadex. Compared to sugammadex, antagonism with neostigmine is more likely to result in incomplete reversal, i.e. residual neuromuscular blockade (rNMB). The administration of additional doses of a reversal agent following an initial reversal dose may be a marker for suspected rNMB. We studied the frequency and temporal patterns of repeat (rescue) administration of reversal agents in patients who received an initial dose of neostigmine vs. sugammadex. Methods: We analyzed retrospective data from electronic anesthesia records to identify surgical patients who received rescue dose reversal, defined as two or more doses of reversal agent, following administration of non-depolarizing NMB and extubation in the operating room. We assessed rates of rescue reversal over time following the introduction of sugammadex and compared rescue rates for patients receiving neostigmine vs sugammadex. Results: A total of 24,027 cases using cisatracurium, rocuronium, and vecuronium were analyzed. Following the addition of sugammadex to formulary in 2016, reversal with neostigmine decreased from 79% to 5.3% (p <0.001) and the use of rescue reversal after neostigmine increased from 6.0% to 18% (p<0.001). In contrast, rescue reversal after sugammadex was 2.5%, with no change over the study period (p=0.059). The percentage of patients who were not given any reversal agent following non-depolarizing NMB decreased from 20% to 13% (p<0.001). As neostigmine usage progressively decreased after introduction of sugammadex, there was a corresponding increase in rescue reversal dosing when initial reversal was attempted with neostigmine. Conclusions: Repeated administration of a reversal agent was 7 times more likely to occur in patients initially reversed with neostigmine compared to sugammadex. This finding likely reflects increased rates of observed weakness in patients reversed with neostigmine. The correlation between decreasing neostigmine use and increasing rescue reversal after neostigmine may indicate a progressive decline in the effective use of neostigmine (as knowledge and experience waned), and/or decreasing confidence in its efficacy.
Drug Repositioning Suggests a Role for the Heat Shock Protein 90 Inhibitor Geldanamycin in Treating COVID-19 Infection
Authors: Sultan Iyad , Howard Scott , Tbakhi Abdelghani
Published: March 2020

Drug repositioning offers an unmatched opportunity to offer novel therapeutics to treat SARS family of coronaviruses (SARS-FCoVs); an issue that became extremely urgent with the spreading of a novel virus with potential to threaten the lives of millions of people. Hereby, we analyzed a dataset of patients who presented with SARS during the 2003 outbreak. We established a gene signature that defines differential gene expression in patients who were sick with SARS vs. healthy controls and convalescent patients. We used a robust platform to conduct drug repositioning based on clustered gene expression and pathway enrichment to identify best matching drugs. We identified 55 agents of potential benefit. In most of these drugs we were able to establish a link to previous related research, use as antiviral, or at least a hypothetical role in treating SARS-FCoVs. Most notably, the heat shock protein 90 (hsp90) emerged as a major component that enables viruses to hijack infected cells through the process of autophagy. Almost half of the drugs identified could be linked to hsp90. As such, we propose using hsp90 inhibitors, mainly geldanamycin and its derivatives, to treat COVID-19.
Re-Invigorating Hibar Research for the 21st Century: Enhancing Fundamental Research Excellence In Service to Society
Authors: Whitehead Lorne A. , Slovic Scott H. , Nelson Janet E.
Published: March 2020

More than ever, society needs research breakthroughs to address major problems. Universities have a key role to play in discovering the required new knowledge and guiding its application. However, since World War II, universities have been encouraged to focus mainly on curiosity-based
research, with corporations carrying out practical work. This division worked well in the last half of the 20th century, when there was considerable funding for long-term research in the laboratories of major corporations. Today, however, those firms face greater competition, and the
resultant financial constraints have foreshortened their research time-horizons. Universities are poised to compensate by re-emphasizing long-term, application-oriented research, but great care must be taken to strengthen fundamental research as well. These objectives can be achieved simultaneously
by bolstering a time-honored class of research projects labelled Highly Integrative Basic And Responsive (HIBAR), each of which combines fundamental and applied approaches through partnerships with practical experts. This approach will help repli- cate, within universities, the breakthrough-generation
capacity that once flourished in major corporate laboratories. Toward this end, a network of universities called the HIBAR Research Alliance (HRA) has recently formed to strengthen HIBAR research, both by helping universities to encourage it (while also improving equity, diversity, inclusion,
and academic freedom) and by helping researchers to carry out HIBAR research projects (while also advancing their careers). The HRA aims to increase the rate of HIBAR research projects in universities—from about one project in 20 today to one in five by 2030—while strengthening
all types of research excellence.
Formulating Industry-Academic Collaborations That Work: Best Practices to Ensure a Strong Relationship After the Agreements are Signed
Authors: Dilling Michael B. , DiSante Anne C. , Durland Ross , Flynn Christine E. , Metelitsa Leonid , Selvamanickam- Venkat
Published: March 2020

Collaborations between academia and industry are growing in scope, duration, and sophistication. The best collaborations recognize the unique strengths and skill sets of both parties and are structured to leverage what each party does best. In many cases, these collaborations develop
into long-term relationships, and it is important to develop the systems and structures needed to support these relationships to ensure that they meet the needs of both sides. Successful collaborations require the formulation of a governance structure to facilitate communication, decision-making,
assessment of progress, and the inevitable changes of direction that accompany product development. This panel explored the pragmatic aspects of successfully structuring collaborations and managing the relationships after the deal is done. Several dominant themes associated with successful
collaborative relationships emerged from the discussion, and these will be explored in this article.
An exploration of group-based compassion-focused therapy for adolescents and their parents
Authors: Bratt Anna Sofia , Rusner Marie , Svensson Idor
Published: March 2020

Background:

The long-term negative consequences of mental health problems during adolescence highlight the need for effective treatments. Compassion-focused therapy (CFT) aims to help individuals to enhance their ability to support and care for themselves and to alleviate shame and self-stigmatization.

Objective:

This non-randomized controlled trial examined the effectiveness of group-based CFT on perceived stress and the extent of self-compassion in a clinical sample of adolescents receiving psychiatric care for complex mental health difficulties and their parents.

Method:

The participants were 43 adolescents (ages 14–17; 83.7 % female) under treatment at a child and adolescent psychiatric outpatient clinic in Sweden and their parents (n = 77; 61 % female). The adolescents volunteered for group-based CFT (n = 19); if they did not want to participate, they were asked to join the control group receiving treatment as usual (TAU, n = 24). The CFT parents were given the same treatment as their children in parallel parent groups. The participants completed questionnaires measuring self-compassion and perceived stress before and after treatment. Paired samples t-tests and independent samples t-tests assessed the within-group and between-group differences via change scores.

Results:

The fathers scored highest on self-compassion and had less perceived stress at both times than the adolescents or mothers. There were no significant differences between the CFT and TAU groups in self-compassion or perceived stress at either time, and the effect sizes were small (g ≤ 0.25). The TAU mother group was the only group with a significantly changed mean self-compassion score post-treatment.

Conclusions:

Some patients seem to benefit from group-based CFT in ways similar to the benefits of specialized therapeutic approaches. Further research into the utility of CFT for adolescents with MH problems and their parents, as well as the long-term clinical effects of CFT for this group is needed.
Editorial
Authors: Nonato Nyelson da Silva
Published: March 2020

Editorial.
Tolerancja ultrahipofrakcjonowanej radioterapii metodą SBRT raka stercza przy użyciu aparatu Cyberknife
Authors: Mańczak Aleksandra , Milecki Piotr
Published: March 2020

Rak stercza jest najczęściej występującym nowotworem wśród mężczyzn po 60 roku życia. Radioterapia (RT) będąca jednym z najmniej inwazyjnych sposobów leczenia, często jest skojarzona z innymi metodami lub jest stosowana samodzielnie. W leczeniu raka stercza coraz częściej stosowana jest także RT hipofrakcjonowana polegająca na podaniu większej dawki frakcyjnej aniżeli konwencjonalnej, zachowując przy tym mniejszą dawkę całkowitą, w porównaniu do napromieniania konwencjonalnego. Hipofrakcjonowana RT stereotaktyczna (SBRT) będąca przedmiotem tego badania, była realizowana na aparacie Cyberknife. Tolerancję leczenia można określić jako stopień występowania powikłań po zastosowanej RT. Jeśli skutki uboczne leczenia występują rzadko, są słabo nasilone i nie powodują obniżenia jakości życia pacjenta - tolerancja leczenia jest dobra. W niniejszej pracy zbadano ocenę tolerancji leczenia hipofrakcjonowaną RT u pacjentów z rakiem stercza, leczonych w Zakładzie Radioterapii I w Wielkopolskim Centrum Onkologii w latach 2013-2014. Chorzy byli napromieniani na aparacie Cyberknife metodą SBRT z dawką frakcyjną 7,0 Gy - 7,25 Gy podawaną 5 krotnie, co dwa dni, do dawki całkowitej 35,0 Gy - 36,25Gy. Oceny tolerancji terapii dokonano na podstawie wypełnianych przez pacjentów ankiet składających się z kwestionariusza IPSS wypełnianych w okresie przed leczeniem, po podaniu ostatniej frakcji, po 1 oraz 24 miesiącach od zakończonej RT. Średnia wieku pacjentów wynosiła 69 lat, średni wynik PSA – 9, a średni wynik sumy Gleason – 6. Na podstawie uzyskanych wyników stwierdzono, że u wszystkich pacjentów wystąpiły objawy ze strony układu moczowego w okresie podania ostatniej frakcji napromieniania oraz miesiąca po zakończeniu leczenia, natomiast po 24 miesiącach od RT poziom ten był porównywany z wynikiem przed leczeniem. Wyniki badania potwierdzają dobrą tolerancję hipofrakcjonowanej SBRT raka stercza, co pokrywa się z aktualnym stanem wiedzy na ten temat i sugerują, że SBRT ze względu na krótszy czas leczenia, równie wysoką skuteczność oraz dobrą tolerancję, w przyszłości mogłoby zastąpić konwencjonalne metody RT w leczeniu raka gruczołu krokowego.
Outcomes Associated with Treatment of Hyperthyroidism with Radioiodine; A Single Center Retrospective Study
Authors: Muhammad Zeeshan Siddiqui  , Ssakher Muteb Alotaibi  , Gulshad Hasan  , Abdullah Faisal Raja Almoshadq  , Nebras Saad Alsaygh  , Hanan Yahya Muabbar  , Zahid Rahman Khan
Published: March 2020

Background:  Hypothyroidism and hyperthyroidism are prevalent conditions with potentially crippling health consequences that globally affect all populations. Hyperthyroidism is overproduction and persistent release of thyroid hormones that can be stratified into a number of subtypes with varying magnitudes and treatment outcomes. Despite of decades of treatment of hyperthyroidism with radioiodine, the success of treatment is still debatable and influenced by many factors. 
Objective: To determine outcomes associated with treatment of hyperthyroidism with radioiodine.
Methods: All patients screened for thyroid disease at King Abdullah Medical City, Makkah in between 2012-17 were included in the analysis (N = 353). Eighteen questions were used to assess the presence or absence of symptoms associated with hyperthyroidism. 251 out of 353 patients were found eligible for screening with thyroid-stimulating hormone, free triiodothyronine (fT3) and free thyroxin (fT4). On the basis of laboratory analysis, 73 patients were eligible for the differing RAI therapeutic regimens. Treatment outcomes were assessed 6 months after the patients received RAI therapy, at which time they were classified as being hypothyroid, euthyroid, or hyperthyroid.
Results: Females were predominantly affected by hyperthyroidism (75.2%) compared with males (24.8%). However, males were significantly more likely than females to have Graves’ ophthalmopathy (p < 0.01), anxiety (p < 0.05), and insomnia (p < 0.05). A total RAI dose of ≤15 mCi was effective in eliminating most hyperthyroidism: ≤12 mCi, 26/29 = 89.7%; 12.1–15 mCi, 28/30 = 93.3%. Using bivariate analysis, the association of treatment effectiveness with each of the symptoms and comorbidities revealed significant correlations only for diabetes mellitus (rho = −0.428, p < 0.001).
Conclusions: Our data suggests that radioiodine remains an effective option of treating hyperthyroidism in most of the patients who qualify for it.
Function of Haroa oral tradition practices in religious life towards Muna society
Authors: Suraya Rahmat Sewa , Kumbara A.A. Ngurah Anom , Pujaastawa Ida Bagus Gde , Wiasti Ni Made , Jers La Ode Topo
Published: March 2020

This paper aimed to observe the practice of Haroa oral traditions as a local culture related to the religious life of the Muna society. The Muna society was one of the ethnic groups in Southeast Sulawesi whose majority religion was Muslim. In the practice of religious life, the Muna society had oral tradition practices that had been passed down for generations, especially, those related to celebrating important days in the Islamic religion. In the current era, the Haroa oral tradition is still practiced by the Muna society although some society considers the tradition to be inappropriate even from certain Islamic groups, assuming tradition is very contrary to the teachings of the Islamic religion. A view assumes the practice of tradition is an act that is considered old-fashioned, upholding-is or heresy and so on. However, the Muna society who carry out the Haroa tradition considers the Haroa tradition has a very useful function for the society, especially, social life, cultural, and religious life.
PENINGKATAN KEMAMPUAN GURU MENYUSUN RENCANA KEGIATAN HARIAN BERBASIS BUDAYA MELALUI KEGIATAN SUPERVISI AKADEMIK DAN PENDAMPINGAN DI TK BINAAN PADA SEMESTER 1 TAHUN 2016/2017
Authors: Sukarmi -
Published: March 2020

Penelitian ini bertujuan untuk mengamati kemampuan guru dalam mengaplikasikan rencana kegiatan harian berbasis budaya. Penelitian  dilaksanakan di TK binaan Kecamatan Wirobrajan dan ikuti sebanyak 12 guru. Model penelitian yang digunakan adalah penelitian tindakan kelas. Metode yang digunakan adalah angket dan wawancara. Analisis yang digunakan adalah teknik deskriptif kuantitatif. Hasil yang diperoleh dari siklus satu menunjukkan bahwa peserta yang mencapai hasil cukup 4 orang atau 33,33%, dan memperoleh hasil baik 8 orang atau 66,67% di bidang ketrampilan. Sejumlah 7 orang atau 58,33 % nilai cukup dan 5 orang dengan nilai baik atau 41,67% di bidang pengetahuan. Nilai cukup 5 orang atau 41,67% dan 7 orang atau 58,33% memperoleh nilai baik pada nilai sikap. Hasil yang diperoleh dari siklus dua yaitu sesi ketiga pendalaman materi dan sesi keempat pemberian tugas dan evaluasi menunjukkan bahwa peserta yang mencapai hasil baik di bidang ketrampilan sejumlah 10 orang atau 83,33%, 9 orang atau 75%  baik dari nilai pengetahuan dan 9 orang atau 75% baik dalam nilai sikap. Kata kunci: penyusunan rencana kegiatan harian berbasis budaya, supervisi akademik.
A Mobile Health Coaching Intervention for Controlling Hypertension: Single-Arm Pilot Pre-Post Study
Authors: Weerahandi Himali , Paul Soaptarshi , Quintiliani Lisa M , Chokshi Sara , Mann Devin M
Published: March 2020

Background

The seminal Dietary Approaches to Stopping Hypertension (DASH) study demonstrated the effectiveness of diet to control hypertension; however, the effective implementation and dissemination of its principles have been limited.

Objective

This study aimed to determine the feasibility and effectiveness of a DASH mobile health intervention. We hypothesized that combining Bluetooth-enabled data collection, social networks, and a human coach with a smartphone DASH app (DASH Mobile) would be an effective medium for the delivery of the DASH program.

Methods

We conducted a single-arm pilot study from August 2015 through August 2016, using a pre-post evaluation design to evaluate the feasibility and preliminary effectiveness of a smartphone version of DASH that incorporated a human health coach. Participants were recruited both online and offline.

Results

A total of 17 patients participated in this study; they had a mean age of 59 years (SD 6) and 10 (60%) were women. Participants were engaged with the app; in the 120 days of the study, the mean number of logged blood pressure measurements was 63 (SD 46), the mean number of recorded weight measurements was 52 (SD 45), and participants recorded a mean of 55 step counts (SD 36). Coaching phone calls had a high completion rate (74/102, 73%). The mean number of servings documented per patient for the dietary assessment was 709 (SD 541), and patients set a mean number of 5 (SD 2) goals. Mean systolic and diastolic blood pressure, heart rate, weight, body mass index, and step count did not significantly change over time (P>.10 for all parameters).

Conclusions

In this pilot study, we found that participants were engaged with an interactive mobile app that promoted healthy behaviors to treat hypertension. We did not find a difference in the physiological outcomes, but were underpowered to identify such changes.
Surveilling Influenza Incidence With Centers for Disease Control and Prevention Web Traffic Data: Demonstration Using a Novel Dataset
Authors: Caldwell Wendy K , Fairchild Geoffrey , Del Valle Sara Y
Published: March 2020

Background

Influenza epidemics result in a public health and economic burden worldwide. Traditional surveillance techniques, which rely on doctor visits, provide data with a delay of 1 to 2 weeks. A means of obtaining real-time data and forecasting future outbreaks is desirable to provide more timely responses to influenza epidemics.

Objective

This study aimed to present the first implementation of a novel dataset by demonstrating its ability to supplement traditional disease surveillance at multiple spatial resolutions.

Methods

We used internet traffic data from the Centers for Disease Control and Prevention (CDC) website to determine the potential usability of this data source. We tested the traffic generated by 10 influenza-related pages in 8 states and 9 census divisions within the United States and compared it against clinical surveillance data.

Results

Our results yielded an r2 value of 0.955 in the most successful case, promising results for some cases, and unsuccessful results for other cases. In the interest of scientific transparency to further the understanding of when internet data streams are an appropriate supplemental data source, we also included negative results (ie, unsuccessful models). Models that focused on a single influenza season were more successful than those that attempted to model multiple influenza seasons. Geographic resolution appeared to play a key role, with national and regional models being more successful, overall, than models at the state level.

Conclusions

These results demonstrate that internet data may be able to complement traditional influenza surveillance in some cases but not in others. Specifically, our results show that the CDC website traffic may inform national- and division-level models but not models for each individual state. In addition, our results show better agreement when the data were broken up by seasons instead of aggregated over several years. We anticipate that this work will lead to more complex nowcasting and forecasting models using this data stream.
Bridging the Gap in Community Care for Patients With Borderline Personality Disorder: Protocol for Qualitative Inquiry Into Patient, Caregiver, and Clinician Perspectives on Service Gaps and Potential Solutions for Severe Emotion Dysregulation
Authors: Friesen Laura , Gaine Graham , Klaver Ellen , Klingle Kirsten , Parmar Devashree , Hrabok Marianne , Kelland Jill , Surood Shireen , Agyapong Vincent
Published: March 2020

Background

Borderline personality disorder (BPD) is characterized by severe emotion dysregulation that is often complicated by comorbid diagnoses, deliberate self-harm, and chronic suicidal ideation. Unfortunately, current care pathways for individuals with BPD are strained by limited resources, inadequate training, and an overuse of emergency departments and crisis teams. Such barriers result in delayed access to effective treatment, which increases risk of deterioration, disability, and morbidity. A first step toward addressing these limitations of the current care pathway is to understand key stakeholders’ lived experiences in this pathway and their perspectives on potential solutions.

Objective

The purpose of this paper is to present a protocol for a study that explores the lived experiences of the current care pathway from the perspectives of patients with BPD, as well as their caregivers and clinicians.

Methods

A qualitative approach is most appropriate for the exploratory nature of the research objective. Accordingly, 3 to 6 patients with a diagnosis of BPD, 3 caregivers of individuals with BPD, and 3 clinicians of patients diagnosed with BPD will be invited to participate in individual, semistructured interviews that focus on service experiences.

Results

It is anticipated that results will yield insight into the lived experiences of patients with BPD, caregivers, and clinicians and provide a better understanding of the perceived gaps in services and potential solutions. Results are expected to be available in 12 months.

Conclusions

This paper describes a protocol for a qualitative study that seeks to understand the lived experiences and perspectives of key stakeholders (patients, caregivers, and clinicians) on the current care pathway for BPD. Results will provide a basis for future research in this area and will have the potential to inform training, practice, and policy.

International Registered Report Identifier (IRRID)

DERR1-10.2196/14885
Summarizing Complex Graphical Models of Multiple Chronic Conditions Using the Second Eigenvalue of Graph Laplacian: Algorithm Development and Validation
Authors: Faruqui Syed Hasib Akhter , Alaeddini Adel , Chang Mike C , Shirinkam Sara , Jaramillo Carlos , NajafiRad Peyman , Wang Jing , Pugh Mary Jo
Published: March 2020

Background

It is important but challenging to understand the interactions of multiple chronic conditions (MCC) and how they develop over time in patients and populations. Clinical data on MCC can now be represented using graphical models to study their interaction and identify the path toward the development of MCC. However, the current graphical models representing MCC are often complex and difficult to analyze. Therefore, it is necessary to develop improved methods for generating these models.

Objective

This study aimed to summarize the complex graphical models of MCC interactions to improve comprehension and aid analysis.

Methods

We examined the emergence of 5 chronic medical conditions (ie, traumatic brain injury [TBI], posttraumatic stress disorder [PTSD], depression [Depr], substance abuse [SuAb], and back pain [BaPa]) over 5 years among 257,633 veteran patients. We developed 3 algorithms that utilize the second eigenvalue of the graph Laplacian to summarize the complex graphical models of MCC by removing less significant edges. The first algorithm learns a sparse probabilistic graphical model of MCC interactions directly from the data. The second algorithm summarizes an existing probabilistic graphical model of MCC interactions when a supporting data set is available. The third algorithm, which is a variation of the second algorithm, summarizes the existing graphical model of MCC interactions with no supporting data. Finally, we examined the coappearance of the 100 most common terms in the literature of MCC to validate the performance of the proposed model.

Results

The proposed summarization algorithms demonstrate considerable performance in extracting major connections among MCC without reducing the predictive accuracy of the resulting graphical models. For the model learned directly from the data, the area under the curve (AUC) performance for predicting TBI, PTSD, BaPa, SuAb, and Depr, respectively, during the next 4 years is as follows—year 2: 79.91%, 84.04%, 78.83%, 82.50%, and 81.47%; year 3: 76.23%, 80.61%, 73.51%, 79.84%, and 77.13%; year 4: 72.38%, 78.22%, 72.96%, 77.92%, and 72.65%; and year 5: 69.51%, 76.15%, 73.04%, 76.72%, and 69.99%, respectively. This demonstrates an overall 12.07% increase in the cumulative sum of AUC in comparison with the classic multilevel temporal Bayesian network.

Conclusions

Using graph summarization can improve the interpretability and the predictive power of the complex graphical models of MCC.
Detection of Atrial Fibrillation Using a Ring-Type Wearable Device (CardioTracker) and Deep Learning Analysis of Photoplethysmography Signals: Prospective Observational Proof-of-Concept Study
Authors: Kwon Soonil , Hong Joonki , Choi Eue-Keun , Lee Byunghwan , Baik Changhyun , Lee Euijae , Jeong Eui-Rim , Koo Bon-Kwon , Oh Seil , Yi Yung
Published: March 2020

Background

Continuous photoplethysmography (PPG) monitoring with a wearable device may aid the early detection of atrial fibrillation (AF).

Objective

We aimed to evaluate the diagnostic performance of a ring-type wearable device (CardioTracker, CART), which can detect AF using deep learning analysis of PPG signals.

Methods

Patients with persistent AF who underwent cardioversion were recruited prospectively. We recorded PPG signals at the finger with CART and a conventional pulse oximeter before and after cardioversion over a period of 15 min (each instrument). Cardiologists validated the PPG rhythms with simultaneous single-lead electrocardiography. The PPG data were transmitted to a smartphone wirelessly and analyzed with a deep learning algorithm. We also validated the deep learning algorithm in 20 healthy subjects with sinus rhythm (SR).

Results

In 100 study participants, CART generated a total of 13,038 30-s PPG samples (5850 for SR and 7188 for AF). Using the deep learning algorithm, the diagnostic accuracy, sensitivity, specificity, positive-predictive value, and negative-predictive value were 96.9%, 99.0%, 94.3%, 95.6%, and 98.7%, respectively. Although the diagnostic accuracy decreased with shorter sample lengths, the accuracy was maintained at 94.7% with 10-s measurements. For SR, the specificity decreased with higher variability of peak-to-peak intervals. However, for AF, CART maintained consistent sensitivity regardless of variability. Pulse rates had a lower impact on sensitivity than on specificity. The performance of CART was comparable to that of the conventional device when using a proper threshold. External validation showed that 94.99% (16,529/17,400) of the PPG samples from the control group were correctly identified with SR.

Conclusions

A ring-type wearable device with deep learning analysis of PPG signals could accurately diagnose AF without relying on electrocardiography. With this device, continuous monitoring for AF may be promising in high-risk populations.

Trial Registration

ClinicalTrials.gov NCT04023188; https://clinicaltrials.gov/ct2/show/NCT04023188