bluuebunny/crossref_metadata_2025 huggingface dataset:
New Insights into Pharmaceutical Nanocrystals for the Improved Topical
Delivery of Therapeutics in Various Skin Disorders
Authors: Singh Vanshita , Bansal Keshav , Bhati Hemant , Bajpai Meenakshi
Published: November 2023

Nanotechnology has provided nanostructure-based delivery of drugs, among which
nanocrystals have been investigated and explored for feasible topical drug delivery. Nanocrystals
are nano-sized colloidal carriers, considered pure solid particles with a maximum drug load and a
very small amount of stabilizer. The size or mean diameter of the nanocrystals is less than 1 μm
and has a crystalline character. Prominent synthesis methods include the utilization of microfluidic-
driven platforms as well as the milling approach, which is both adaptable and adjustable.
Nanocrystals have shown a high capacity for loading drugs, utilization of negligible amounts of
excipients, greater chemical stability, lower toxic effects, and ease of scale-up, as well as manufacturing.
They have gained interest as drug delivery platforms, and the significantly large surface
area of the skin makes it a potential approach for topical therapeutic formulations for different
skin disorders including fungal and bacterial infections, psoriasis, wound healing, and skin
cancers, etc. This article explores the preparation techniques, applications, and recent patents of
nanocrystals for treating various skin conditions.
Premenstrual Syndrome: An Overview of the Review Analysis, and Potential Role of Herbal and Dietary Supplements
Authors: Kumari Pooja , Saxena  Pal Rashmi , Lalitha Chaitanya Motamarri Venkata Naga , Pal Yogendra , Punniyakotti Saranya
Published: November 2023

:

A premenstrual syndrome is a group of regular physiological, mental, emotional, and
behavioral symptoms that appear periodically in the luteal phase of the menstrual cycle, and they
vanish quickly with the beginning of menstruation or a few days afterward. Thus, severe premenstrual
syndrome (PMS) affects 5–8% of women; the majority of these individuals also match the
factors for premenstrual dysphoric disorder (PMDD). Premenstrual syndrome typically includes
physical problems like headache, tiredness, indigestion, insomnia, nausea, and breast tenderness
as well as symptoms associated with emotions (mood swings, anxiousness, and aggressiveness).
Although the true mechanism of PMS is unknown, a number of theories point to increased sensitivity
to typical hormonal changes and imbalances in neurotransmitters. A multidisciplinary team
using an integrative holistic approach in the direction of an individualized strategy gradually manages
PMS. The first phase entails educating women about PMS, self-screening, herbs like St John’s
Wort, chaste berry, saffron; ginkgo biloba; chamomile, evening primrose, turmeric and so on,
various nutrition supplements as Vitamin B6; calcium; magnesium and lifestyle adjustments like
dietary modifications; exercise; yoga; sleep hygiene. The second step involves implementing various
relaxation therapies, cognitive behavioral therapy (CBT), stress reduction techniques, and
acupuncture. The available treatment as various drugs like SSRIs; serotonergic antidepressants;
anxiolytics and hormonal therapy that are used currently to treat PMS, exhibits unwanted side effects.
Therefore, this issue and other similar gynecological conditions have been discussed and managed
with herbal medicines and other natural solutions in this comprehensive piece of work.
Diagnosis of Benign and Malignant BI-RADS 4 Breast Masses by Contrastenhanced
Ultrasound Combined with Shear Wave Elastography
Authors: Weng Lifeng , Yu Mengxia
Published: November 2023

Background::

Breast cancer, one of the most prevalent malignant tumors in females, usually occurs in the breast epithelial tissues.

Objective::

The study aimed to explore the diagnostic value of contrast-enhanced ultrasound (CEUS) combined with shear wave elastography (SWE) in the
diagnosis of benign and malignant breast masses in BI-RADS (Breast Imaging Reporting and Data System) 4.

Methods::

Examination outcomes and clinical information of 83 patients with BI-RADS 4 breast masses were analyzed retrospectively. These included
patients who received CEUS, SWE, and pathological examinations. The difference of CEUS in determining the classification of BI-RADS 4 breast
masses was evaluated using histopathological outcomes of breast masses as a reference standard. The diagnostic value of CEUS, SWE, and CEUS
combined with SWE in the diagnosis of benign and malignant breast masses in BI-RADS 4 was also explored.

Results::

Pathological biopsy results revealed 63 malignant masses and 20 benign masses among 83 BI-RADS 4 breast masses, with a 75.9% incidence of
malignant masses. After the diagnosis of BI-RADS 4 breast masses with CEUS, SWE, and CEUS+SWE, the incidence of malignancy was 56.6%,
78.3%, and 73.5%, respectively. CEUS+SWE showed higher sensitivity (93.7% vs. 81% and 68.3%), specificity (90% vs. 30% and 80%), positive
predictive value (96.7% vs. 78.5% and 91.5%), negative predictive value (81.8% vs. 33.3% and 44.4%), and diagnostic coincidence rate (92.8% vs.
68.7% and 71.1%) than SWE and CEUS alone in diagnosing pathological type of breast masses. Moreover, CEUS combined with SWE exhibited a
larger area under the receiver operating characteristic (ROC) curve (0.918) than SWE (0.741, p = 0.028) and CEUS (0.555, p < 0.001) alone in the
diagnosis of BI-RADS 4 breast masses.

Conclusion::

Overall, the diagnostic value of CEUS+SWE for the pathological type of BI-RADS is preferred over CEUS and SWE alone. CEUS+SWE showed
higher values than CEUS and SWE alone in diagnosing BI-RADS 4 breast masses. Specifically, CEUS+SWE can correctly identify benign and
malignant masses, reduce unnecessary trauma, and avoid misdiagnosis. In summary, CEUS combined with SWE can serve as an effective
diagnostic method and avoid delaying the best treatment opportunity for some malignant lesions.
Ultrasound-based Radiomics for Predicting Metastasis in the Lymph Nodes
Posterior to the Right Recurrent Laryngeal Nerve in Patients with Papillary
Thyroid Cancer
Authors: Shen Bo , Zhou Chao , Xu Chaoli , Yang Bin , Wu Xiaoman , Fu Xiaodan , Liu Siyue , Sun Jiaying , Xie Yingdong , Zhu Zheng
Published: November 2023

Background::

Dissection of the lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLNs) in papillary thyroid cancer (PTC) remains
controversial.

Objective::

This study aimed to determine the capability of ultrasonography (US)-based radiomics for presurgical prediction of metastasis in LN-prRLNs in
PTC.

Methods::

Patients were retrospectively enrolled and pathologically confirmed as LN-prRLN metastasis with PTC after surgery. Radiomic analysis based on
preoperative US images with manual segmentation of targets was used to develop a radiomics model. US features described in ACR TI-RADS
were collected to construct a clinical model. The Radiomics model, a combined model integrating radiomics and clinical model, was also
developed for the presurgical prediction of metastasis in LN-prRLNs.

Results::

A total of 570 patients, including 488 patients with non-LN-prRLN metastasis and 82 with LN-prRLN metastasis, were assessed. The 15 topperforming
features finally remained significant for constructing the radiomics model. The combined model showed that US measured tumor size
(OR: 1.036, P = 0.044), US suspected lateral lymph node metastasis (OR: 2.247, P = 0.009), multifocality (OR: 1.920, P = 0.021), Delphian lymph
node metastasis (DLNM) (OR: 2.300, P = 0.039), VIa compartment metastasis (OR: 5.357, P = 0.000), the radiomics score (OR: 1.003, P = 0.001)
were significant risk factors for predicting LN-prRLN metastasis. The combined model achieved a higher AUC of 0.849 than that of the clinical
model (AUC: 0.759) and radiomics model (AUC: 0.826).

Conclusion::

The US-based radiomics combined model can more effectively predict LN-prRLN metastasis in PTCs patients preoperatively. This approach had
the potential to assist surgeons indecision-making regarding LN-prRLN dissection.
Radial Endobronchial Ultrasound-guided Transbronchial Cryobiopsy versus Forceps Biopsy for the Diagnosis of Solitary Pulmonary Nodules: A Prospective Randomised Trial
Authors: Brown Michael , Nguyen Phan , Jersmann Hubertus , Holmes Mark , Wong Michelle
Published: November 2023

Background:

Improvements in pulmonary diagnostic imaging and the development of lung cancer screening are increasing the prevalence of Solitary pulmonary nodules (SPNs). Fluoroscopically guided radial endobronchial ultrasound (EBUS) with transbronchial forceps biopsy (TB-FB) has been the conventional diagnostic method. Transbronchial cryobiopsy (TB-CB) is an alternative biopsy method. We sought to compare transbronchial cryobiopsy to transbronchial forceps biopsy for the diagnosis of SPNs.

Methods:

A prospective, single-centre, randomised controlled trial was conducted at the Royal Adelaide Hospital (RAH). Patients with SPNs were randomised to either 5 transbronchial forceps biopsies or one transbronchial cryobiopsy. Complete blinding of investigators and participants was not possible, as transbronchial cryobiopsy required general anaesthesia. The primary outcome was diagnostic yield with secondary outcomes of specimen size, diagnostic yield for subsets challenging to access with forceps and safety.

Results:

The overall diagnostic yield for the 28 enrolled subjects was 76.8%(22/28). The diagnostic yield was 91.7% (11/12 patients) for transbronchial cryobiopsy and 68.8% (11/16 patients) for forceps biopsy (p=0.14). Median biopsy sizes were consistently larger for the cryobiopsy arm at 7.0mm compared to 2.5mm(p<0.0001). An eccentric EBUS image signalling the probe was adjacent to the nodule occurred in 4/28 cases, and TB-CB confirmed a diagnosis in 3/3 randomised to this arm. There were no major complications with either technique.

Conclusion:

Transbronchial cryobiopsy under the guidance of fluoroscopy and radial EBUS facilitates larger biopsy specimens without a significant increase in major complications. Further research is required to confirm the effect on diagnostic yield; however, our study supports a role for TB-CB in the diagnosis of SPNs and small, nodule-adjacent biopsies.

Clinical Trial Registration Number:

Reference number of R20160213(HREC/16/RAH/37).
A Critical Study on the Synthetic and Herbal Medication Pattern in the
Management of Psoriasis
Authors: Chandel Shobhini , Das Saumya , Neha Neha , Chauhan Vijayant Singh
Published: November 2023

Psoriasis is a persistent skin illness that causes dense, shimmering flakes, irritable,
dry, and red patches as a result of the fast buildup of skin cells. It is an autoimmune skin condition
that is incurable, non-contagious, and relapsing-remitting. Typically, a remission phase lasts
one to twelve months. Psoriasis is caused by a number of cellular mechanisms, and it has been
hypothesised that T lymphocytes, keratinocytes, allergen cells, Langerhans cells, natural killer
cells, phagocytes, a number of Th1-type chemokines, in addition to growth factors like
endothelial proliferation factor and keratinocytes growth factor, among others, are key players in
the development of psoriasis. Numerous synthetic medicinal drugs have been documented to
have the side effects of psoriasis. Due to the safety and accessibility, herbal medications may
hold promise as possible anti-psoriatic molecules. Before creating a potential herbal drug, it is
important to thoroughly examine the key players in the evolution of psoriasis, such as T-cell
stimulation, transportation, and cytokinase inhibition. The purpose of this review is to investigate
how psoriasis spreads and becomes activated, as well as how certain medications might
exacerbate the condition and how certain plant resources may be used to treat psoriasis. To
create a potent, secure, and dependable treatment, more scientific research on these herbal
resources is required.
Bridge Frost Prediction Using K-nearest Neighbor Classifier
Authors: Jang Jinhwan
Published: November 2023

Background:

Considering the frequent occurrence of accidents on icy bridges during winter nights, it would be advantageous to notify both road managers and drivers regarding the most perilous areas. This notification would allow road managers to address the icy conditions by applying de-icing substances, while drivers could be more adequately prepared for potential hazards.

Methods:

In this study, the focus was on investigating k-nearest neighbor algorithms to predict nighttime icing caused by frost on three distinct bridges located on the National Highways in Korea. The algorithms utilized atmospheric data as input, which was obtained from the weather agency's website through an open API. The input data included relative humidity, air temperature, and dew point temperature, as well as the disparities in air temperature and humidity between two consecutive days.

Results:

In order to assess the effectiveness of the prediction models, reference data were created using the fundamental principle that ice is formed when the temperature of the pavement is below freezing and lower than the dew point temperature. Consequently, the developed algorithm demonstrated favorable performance, achieving an accuracy of 95% when evaluated using a test dataset that occupies 30% of the entire data.

Conclusion:

Considering the increasing focus on preventive maintenance, these newly developed forecasting models can be employed proactively as a preventive measure against icing. This proactive approach will ultimately contribute to improving traffic safety on winter roads.
Exploring the Mechanism of Brucea Javanica against Ovarian Cancer based on Network Pharmacology and the Influence of Luteolin on the PI3K/AKT Pathway
Authors: Zhu Jufan , Han Mengfei , Yang Yiheng , Feng Renqian , Hu Yan , Wang Yuli
Published: November 2023

Background:

Ovarian cancer (OC) is a commonly diagnosed female cancer around the
world. The Chinese herbal medicine Brucea javanica has an anti-cancer effect. However, there is
no relevant report on whether Brucea javanica is effective in treating OC, and the corresponding
mechanism is also unknown.

Objective:

This study was projected to excavate the active components and underpinned molecular
mechanisms of Brucea javanica in treating ovarian cancer (OC) through network pharmacology
combined with in vitro experiments.

Methods:

The essential active components of Brucea javanica were selected using the TCMSP
database. The OC-related targets were selected by GeneCards, intersecting targets were obtained
by Venn Diagram. The core targets were obtained through the PPI network and Cytoscape, and the
key pathway was gained through GO and KEGG enrichment analyses. Meanwhile, docking conformation
was observed as reflected by molecular docking. MTT, colony formation assay and flow
cytometer (FCM) analysis were performed to determine cell proliferation and apoptosis, respectively.
Finally, Levels of various signaling proteins were evaluated by western blotting.

Results:

Luteolin, β-sitosterol and their corresponding targets were selected as the essential active
components of Brucea javanica. 76 intersecting targets were obtained by Venn Diagram. TP53,
AKT1, and TNF were obtained through the PPI network and Cytoscape, and the key pathway
PI3K/AKT was gained through GO and KEGG enrichment analyses. A good docking conformation
was observed between luteolin and AKT1. Luteolin could hinder A2780 cell proliferation,
induce cell apoptosis and enhance the inhibition of the PI3K/AKT pathway.

Conclusion:

It was verified in vitro that luteolin could hinder OC cell proliferation and activate the
PI3K/AKT pathway to lead to apoptosis.
Identifikasi Jenis Tumbuhan Anggrek di UPTD Taman Anggrek Magelang
Authors: Eskundari Ratna Dewi , Cahyanti Fiky Ariska , Fitriani Rindi Diah Ayu , Oktavianingtyas Desty , Wahyuni Tri
Published: November 2023

Identifikasi jenis tumbuhan Anggrek adalah suatu tahapan untuk mengidentifikasi spesies tumbuhan Anggrek yang ditemukan di lokasi penelitian secara runtut sehingga dapat ditemukan taksonominya. Anggrek yang terdapat di kawasan UPTD Taman Anggrek Magelang sangat beragam, mulai dari yang habitat aslinya tumbuh secara secara epifit maupun terestrial. Penelitian ini bertujuan mengetahui keragaman jenis spesies Anggrek di Kawasan UPTD Taman Anggrek Magelang. Metode dalam peneli-tian ini yaitu jelajah (survey eksploratif). Data penelitian ini diambil di wilayah kebun Anggrek UPTD Taman Anggrek Magelang. Instrumen dalam penelitian ini mengguna-kan tabel pengamatan. Berdasar hasil penelitian terdapat 19 spesies Anggrek yang tergolong ke dalam 10 genus dari 1 famili, yang terdapat di UPTD Taman Ang-grek Magelang, diantaranya adalah Ang-grek Arachnis flos-aeris, Vanda dou-glas, Vanda (nilareta agrihorti), Vanda (Orange), Grammatophy-llum speciosum, Dendrobi-um bigibbum, Bulbophyllum lobbii, Den-drobium bicolor, Dendrobum superbiens, Dendrobium Sp., Oncydium spachelatum, Cymbidium bico-lor, Cymbi-dium golden shower, Cymbidium leucochi-llum, Doritis pullcherima pink, Phalaenopsis amabilis (L.), dan Doritaenopsis.
Respon Dosis Pupuk Kandang Ayam dan Konsentrasi Plant Growth Promoting Rhizobacteria (PGPR) pada Pertumbuhan dan Hasil Bawang Merah (Allium ascalonium L.)
Authors: Fembi Dianada Zhikra , Maghfoer Mochammad Dawam
Published: November 2023

Penambahan bahan organik seperti pupuk kandang ayam dapat memperbaiki sifat fisik, kimia, dan biologi tanah. Selain pemberian pupuk kandang ayam, perlu adanya penunjang pertumbuhan lain dengan penambahan PGPR. Penelitian ini bertujuan untuk mendapatkan dosis pupuk kandang ayam yang dikombinasikan dengan konsentrasi Plant Growth Promoting Rhizobacteria (PGPR) secara tepat terhadap pertumbuhan dan hasil tanaman bawang merah (Allium ascalonicum L.). Penelitian dilaksanakan pada bulan Januari hingga Maret 2023 di Desa Mlorah, Kecamatan Rejoso, Kabupaten Nganjuk, Jawa Timur. Metode penelitian menggunakan Rancangan Acak Kelompok (RAK) meliputi: P1: Tanpa pupuk kandang ayam + tanpa PGPR (kontrol); P2: Pupuk kandang ayam 10 ton.ha-1 + PGPR 5 ml.l-1; P3: Pupuk kandang ayam 20 ton.ha-1 + PGPR 5 ml.l-1; P4: Pupuk kandang ayam 10 ton.ha-1 + PGPR 10 ml.l-1; P5: Pupuk kandang ayam 20 ton.ha-1 + PGPR 10 ml.l-1; P6: Pupuk kandang ayam 10 ton.ha-1 + PGPR 15 ml.l-1; P7: Pupuk kandang ayam 20 ton.ha-1 + PGPR 15 ml.l-1; P8: Pupuk kandang ayam 10 ton.ha-1 + PGPR 20 ml.l-1; P9: Pupuk kandang ayam 20 ton.ha-1 + PGPR 20 ml.l-1. Hasil penelitian menunjukkan bahwa dengan penambahan dosis pupuk kandang ayam yang dikombinasikan dengan konsentrasi PGPR mampu meningkatkan panjang tanaman, luas daun, jumlah daun, jumlah anakan, jumlah umbi, diameter umbi, bobot umbi, bobot kering brangkasan, bobot kering umbi, dan berbeda nyata dibandingkan dengan perlakuan tanpa pupuk kandang ayam + tanpa PGPR.
Eksplorasi Trend Produksi Jagung di Nusa Tenggara Timur dan Prediksinya
Authors: Pallo Marchy , Djunina Herlyn , Se’u Vivin Elmiyati , Mulik Yelly
Published: November 2023

Di Nusa Tenggara Timur, Jagung adalah komoditi utama yang paling di minati baik untuk usaha tani mau pun untuk dikonsumsi. Tingkat konsumtif masyarakat yang meningkat berbanding lurus dengan perkembangan produksi jagung yang mengalami peningkatan setiap tahunnya sehingga diperlukan ramalan produksi jagung dalam beberapa tahun kedepan agar menjadi tolok ukur dalam mengupayakan ketersediaan jagung. Banyak analisis yang telah berkembang, namun analisis dasar untuk memprediksi adalah analisis trend. Oleh karena itu, tujuan dari penelitian ini adalah untuk mengetahui trend produksi jagung di Nusa Tenggara Timur dan meramalkannya untuk beberapa periode waktu. Hasil penelitian menunjukkan bahwa model trend yang terbaik adalah model trend linier dengan model untuk prediksinya yaitu yt = 399.535 + 12.787t. Hasil ramalan untuk tiga periode berikutnya tahun 2022 sampai 2024 adalah 783.145 ton, 795.932 ton dan 808.719 ton. Plot pada data menunjukkan bahwa tidak banyak perbedaan antara data riil dan prediksi apabila dibandingkan.
Evaluasi Kesehatan Pohon Tepi Jalan di Kawasan Stadion Gajayana Di Kota Malang
Authors: Dharmawan Fadlian Agung , Baskara Medha
Published: November 2023

Kota Malang memiliki 8 tahap perencanaan kota yang dinamakan Bouwplan I hingga VIII yang memiliki tujuan utama dari perluasan ini yaitu pengendalian bentuk kota yang diakibatkan dari pertambahan penduduk serta kemajuan ekonomi. Kota Malang sendiri kerap ditimpa cuaca yang tidak menentu dan musim hujan dengan angin kencang yang memicu banyak pohon yang tumbang yang dapat menimbulkan korban jiwa. Penelitian ini dilaksanakan disekitar kawasan Stadion Gajayana di Kota Malang Tujuan dari penelitian ini mengidentifikasi sebaran jenis pohon dan mengidentifikasi tingkat kesehatan pohon tepi jalan di kawasan Stadion Gajayana di Kota Malang. Metode yang digunakan yaitu sensus dan dianalisis menggunakan metode Forest Health Monitoring (FHM). Berdasarkan hasil penelitian kelas jalan kolektor sekunder memiliki populasi tertinggi yaitu sebanyak 621 pohon yang didominasi oleh spesies palem raja (Roystonea regia). Kelas jalan lokal sekunder memiliki indeks keanekaragaman pada Jalan Taman Slamet menunjukan hasil yang tertinggi yaitu dengan nilai sebesar 2,34 dan kelimpahan dengan nilai kelimpahan sebesar 42,22%. Kemerataan vegetasi tertinggi terdapat pada Jalan Arjuno dan Jalan Widodaren yang memiliki kelas jalan lokal sekunder dengan nilai sebesar 0,85. Kondisi kesehatan pohon tepi jalan tertinggi dengan kondisi sakit ringan sebesar 41% didomiasi pada kelas jalan kolektor sekunder. Lokasi kerusakan didominasi pada batang bagian bawah dengan persentase sebesar 82,19% dan jenis kerusakan terbanyak yaitu lain-lain (vandalisme dan rayap) dengan persentase sebesar 52,54% yang didominasi pada kelas jalan kolektor sekunder.
The Curriculum of Everything: Understanding education and curriculum
Authors: Pacheco José Augusto
Published: November 2023

José A. Pacheco, Ph.D. in Education in the specialty of Curriculum Development, University of Minho, in 1993, is a Full Professor in the Department of Curriculum Studies and Educational Technology at the Institute of Education, University of Minho. His research interests are focused on Curriculum Theory, Curriculum Politics, Teacher Training, and Evaluation. Presently, he is the director of the Ph.D. Science Education Program of the University of Minho, an effective member of the Research Centre on Education of the University of Minho, and a member of the Advisory Board of the Organization of Ibero-American States for Education. He coordinated (2013-2022) two research projects on school external evaluation, financed by national funds through the Foundation for Science and Technology (FCT).
Biblia w Qumran. Addenda
Authors: Klukowski Michał
Published: November 2023

Artykuł porusza problematykę rękopisów biblijnych odkrytych w latach 40. i 50. na Pustyni Judzkiej, w relacji do jedynej polskiej publikacji w języku polskim poświęconej temu zagadnieniu w całości. W artykule zawarte są informacje aktualizujące lub uzupełniające tę publikację w czterech aspektach: problemie identyfikacji tekstów biblijnych oraz sporządzania ich wykazu; kwestii kanonu biblijnego; identyfikacji rodzin tekstualnych w biblijnych tekstach z Pustyni Judzkiej; próbie wyjaśnienia wyłonionych w tych tekstach rodzin tekstualnych.
Use of Epic Electronic Health Record System for Health Care Research: Scoping Review
Authors: Chishtie Jawad , Sapiro Natalie , Wiebe Natalie , Rabatach Leora , Lorenzetti Diane , Leung Alexander A , Rabi Doreen , Quan Hude , Eastwood Cathy A
Published: November 2023

Background

Electronic health records (EHRs) enable health data exchange across interconnected systems from varied settings. Epic is among the 5 leading EHR providers and is the most adopted EHR system across the globe. Despite its global reach, there is a gap in the literature detailing how EHR systems such as Epic have been used for health care research.

Objective

The objective of this scoping review is to synthesize the available literature on use cases of the Epic EHR for research in various areas of clinical and health sciences.

Methods

We used established scoping review methods and searched 9 major information repositories, including databases and gray literature sources. To categorize the research data, we developed detailed criteria for 5 major research domains to present the results.

Results

We present a comprehensive picture of the method types in 5 research domains. A total of 4669 articles were screened by 2 independent reviewers at each stage, while 206 articles were abstracted. Most studies were from the United States, with a sharp increase in volume from the year 2015 onwards. Most articles focused on clinical care, health services research and clinical decision support. Among research designs, most studies used longitudinal designs, followed by interventional studies implemented at single sites in adult populations. Important facilitators and barriers to the use of Epic and EHRs in general were identified. Important lessons to the use of Epic and other EHRs for research purposes were also synthesized.

Conclusions

The Epic EHR provides a wide variety of functions that are helpful toward research in several domains, including clinical and population health, quality improvement, and the development of clinical decision support tools. As Epic is reported to be the most globally adopted EHR, researchers can take advantage of its various system features, including pooled data, integration of modules and developing decision support tools. Such research opportunities afforded by the system can contribute to improving quality of care, building health system efficiencies, and conducting population-level studies. Although this review is limited to the Epic EHR system, the larger lessons are generalizable to other EHRs.
MYTH OF VIOLENCE IN VENOM: LET THERE BE CARNAGE (2021) SEMIOTIC ANALYSIS
Authors: Pratiwi Ayu Dian
Published: November 2023

Popular culture is a product created for many people. The audience’s tastes are essential in production. Besides that, popular culture can also describe a culture that exists in society. One popular product that people like is film. Along with the times, the world of cinema also has more exciting story plots and various characters. One is an American film called Venom: Let There Be Carnage. The film shows signs of the violent formula usually used in American cinema. Therefore, this journal discusses Venom, who is an anti-hero who uses much violence to deliver his existence but has a heroic soul, and also Eddie Brock, an ordinary human who acts as a host who has contradictory traits with Venom even though they live in one body—coupled with conflicts with other villains characters such as Carnage and Cletus Kasady. Researchers present signs of violence using dialogues and movie posters as data references. Also, the characteristics of the heroes used using semiotic analysis supported by John Cawelty’s Myth of Violence theory. With this method, the researcher also describes the culture of violence in American society.
THE FOUR FACTORS DOMINATING ONLINE STREAMING PLATFORMS AS WITNESSED BY NETFLIX IN THE WAKE OF GLOBALIZATION
Authors: Sekartaji Swelana
Published: November 2023

The globalization process has increased everything's accessibility and connectivity. Through information and technology, globalization makes it easier to move products, services, cultures, innovations, and creative ideas. As one of the most popular online streaming services, Netflix is fostering cross-cultural exchanges as part of the increasing globalization of capitalism. The author uses written sources, information, and evidence in the form of quotes from written works, written papers, and written responses to articles, reports, publications, and statistical data that are pertinent to Netflix. The author will apply globalization theory and a transnational approach to investigate why individuals favor Netflix over alternative online streaming services. These two theories are implemented in elaborating four dominant factors that Netflix has influenced the new habit patterns in today's society. Market growth will always play a role in globalization-related economic and cultural activities and processes.  As a result, four key elements affect Netflix’s market dominance: substitution, barriers to entry and potential competition, measures of profitability, and market share.
THE CULTURAL CONSTRUCTION OF BARBIE IN AMERICAN DISCOURSES: NORMAN FAIRCLOUGH’S CRITICAL DISCOURSE ANALYSIS
Authors: Nisa Intan Khoirun , Adi Ida Rochani
Published: November 2023

The cultural construction of Barbie in American Discourses explains how Barbie as an American popular product is seen, talked about, and understood by the public. Barbie, a fashion doll that has successfully developed into an American icon, has been a subject of discussion since its first publication in 1959. The fact that it supposedly played the role of a simple children’s toy yet can capture the adults’ interests shows that there is something particular in Barbie that might also be deemed relevant by the adults. Thus, this study aims to break down the structure of Barbie as an American popular product in American discourses using Norman Fairclough’s theory of Critical Discourse Analysis. Using Barbie itself as the data taken from Barbie’s official Instagram account, this study applies qualitative methods. The result shows that in American discourses, Barbie is seen as the face of the American Dream and a reflection of Idealized American women. Through the depiction of Barbie’s appearance, the narration of Barbie’s abundant leisure activities, the description of Barbie’s lavish possessions, and their socialite peers, Barbie has symbolically served as an icon in the American Dream. Additionally, Barbie’s position in reflecting the image of American women is seen as the idealized epitome of beauty and success. However, she is also perceived as an icon who brings mixed messages. Even though she aims to promote female empowerment, her representation is also presumed to be problematic and unrealistic.
THE REPRESENTATION OF BULLYING IN AMERICAN FILMS
Authors: Br. Ginting Greace Naomi , Rudy Rudy
Published: November 2023

The issue of bullying continues to be reported by the media because it still happens everywhere, especially in schools, and needs to be discussed in research. This qualitative research focuses on studying American films with the theme of bullying, namely Bully (2011), A Girl Like Her (2015), and Wonder (2017) as the main source of data. This study aims to identify how American movies portray bullying and to find out what bullying represents by applying Hall’s representation theory. Dialogs collected and sorted from the films were treated as signs that would convey more meanings. The results of data analysis suggest that American films with the themes of bullying frequently show bullying through portraits of physical violence, verbal violence, and trauma. Besides, bullying can also indicate a lack of attention from the family, the condition of the social environment, and the powerlessness of humans.
Regional Citrate Anticoagulation versus No Anticoagulation for CKRT in Patients with Liver Failure with Increased Bleeding Risk
Authors: Bai Ming , Yu Yan , Zhao Lijuan , Tian Xiujuan , Zhou Meilan , Jiao Jing , Liu Yi , Li Yajuan , Yue Yuan , Wei Lei , Jing Rui , Li Yangping , Ma Feng , Liang Ying , Sun Shiren
Published: November 2023

Background

The opinions on the efficacy and safety of no anticoagulation versus regional citrate anticoagulation for continuous KRT (CKRT) were controversial in patients with severe liver failure with a higher bleeding risk. We performed a randomized controlled trial to assess no anticoagulation versus regional citrate anticoagulation for CKRT in these patients.

Methods

Adult patients with liver failure with a higher bleeding risk who required CKRT were considered candidates. The included participants were randomized to receive regional citrate anticoagulation or no-anticoagulation CKRT. The primary end point was filter failure.

Results

Of the included participants, 44 and 45 were randomized to receive regional citrate anticoagulation and no-anticoagulation CKRT, respectively. The no-anticoagulation group had a significantly higher filter failure rate (25 [56%] versus 12 [27%], P = 0.003), which was confirmed by cumulative incidence function analysis and sensitive analysis including only the first CKRT sessions. In the cumulative incidence function analysis, the cumulative filter failure rates at 24, 48, and 72 hours of the no-anticoagulation and regional citrate anticoagulation groups were 31%, 58%, and 76% and 11%, 23%, and 35%, respectively. Participants in the regional citrate anticoagulation group had significantly higher incidences of Ca2+
tot/Ca2+
ion >2.5 (7% versus 57%, P < 0.001), hypocalcemia (51% versus 82%, P = 0.002), and severe hypocalcemia (13% versus 77%, P < 0.001). However, most (73%) of the increased Ca2+
tot/Ca2+
ion ratios were normalized after the upregulation of the calcium substitution rate. In the regional citrate anticoagulation group, there was no significant additional increase in the systemic citrate concentration after 6 hours.

Conclusions

For patients with liver failure with a higher bleeding risk who required CKRT, regional citrate anticoagulation resulted in significantly longer filter lifespan than no anticoagulation. However, regional citrate anticoagulation in patients with liver failure was associated with a significantly higher risk of hypocalcemia, severe hypocalcemia, and Ca2+
tot/Ca2+
ion >2.5.

Clinical Trial registry name and registration number

RCA for CRRT in Liver Failure and High Risk Bleeding Patients, NCT03791190.
The Old Man and the Sea Revisited in a Linguistic Perspective
Authors: Yang Ping
Published: November 2023

Hemingway’s novel The Old Man and the Sea was published in 1952 and won the Nobel Prize for Literature two years later. As an excellent work created by Hemingway, the language style of the Old Man and the Sea highlights Hemingway’s literary characteristics. He likes to use simple and colloquial language and flexible collocation of verbs and nouns to drive the plot development of the story, and then combine various rhetorical devices with his own language style to enrich the ideas of the whole novel. Many creative skills make the whole novel memorable, fully show the linguistic features of the Old Man and the Sea. From the perspective of linguistics, this paper analyzes the unique aesthetic style created by the powerful expression techniques in the novel. This paper analyzes the novel from two perspectives: linguistic features and metaphorical meaning. In terms of linguistic features, this paper mainly analyzes the concise language style, the ingenious use of personal pronouns and the appropriate code-switching. In terms of metaphorical meaning, this paper mainly analyzes the metaphorical meaning of the old man, the sea, the shark and marlin and the lion in this novel.
El Movimiento de los trabajadores rurales sin tierra. Hegemonía y lucha popular en Brasil
Authors: López de la Vega Mariana
Published: November 2023

El movimiento de los trabajadores rurales sin tierra en Brasil es uno de los movimientos campesinos de Nuestra América que propuso una reforma agraria integral. En este trabajo se presenta un acercamiento a las relaciones sociales y a las fuerzas políticas de Brasil, para ubicar la hegemonía que prevalece y la fuerza de la lucha popular realizada por el MST, así como sus planteamientos políticos y retos en el porvenir combinando la sociología política y las miradas del movimiento.
Las moradas del exilio: la casa de Chile en México (1973 - 1993)
Authors: Rojas Mira Claudia Fedora
Published: November 2023

Con este libro busco contribuir a la comprensión del impacto del exilio político, de los años setenta, en la historia de Chile y México y de esta manera ampliar la visión de la Historia política y social de América Latina en el siglo XX. Chile se abrió al mundo y el mundo se abrió para Chile como nunca en su historia: los exiliados políticos chilenos fueron repartidos y se repartieron por todos los continentes, lo que naturalmente dejó una huella casi universal. México fue uno de los países que dió asilo y acogida a un grupo específico de chilenos y chilenas. Para ello hubo, por una parte, razones históricas, políticas, culturales y académicas y, por otra, alianzas personales que desempeñaron un papel determinante en el apoyo que brindó México al exilio político chileno.
España en el origen del nombre de América Latina
Authors: Ardao Arturo
Published: November 2023

Este trabajo tiene por objeto establecer la participación española en el origen del nombre América Latina. De ahí que se halle centrado en la década de los cincuenta del siglo XIX, aunque diversas referencias la desborden a una y otra punta. En estricto plano de hecho, tanto en América Latina como en la península ibérica ha venido reinando la creencia de que España fue en absoluto extraña a su origen; la creencia, aún, de que dicho origen tuvo un sentido de desvío, cuando no de antagonismo, respecto a la antigua metrópoli. De lo que aquí se trata es poner de relieve la importancia que esos hechos tuvieron en la creación de la entonces.
Estatus ontológico de nuestra América. La filosofía de Antonio Gómez Robledo
Authors: Vela Ramos Alfonso
Published: November 2023

Al interior de la historia de la filosofía latinoamericana, el tema sobre la definición de América Latina ha sido uno de los que mayor interés ha generado. El descubrir de sus raíces y sentido ha ocupado la reflexión de nuestros más grandes pensadores. Por ello, este libro pretende dar voz a una de esas mentes que con singular brillantes profundizó sobre la realidad ontológica de Nuestra América, y que incomprensiblemente no ha sido debidamente estudiado, nos referimos al maestro Antonio Gómez Robledo. Su agudo filosofar, nos guía en un viaje singular por las regiones del ser de Nuestra América al recuperar los aspectos más sustanciales del filosofar clásico, situándolos en una realidad concreta, para nada ajena al ritmo de la vida. Así, y con una particular propuesta de la metodología de la historia de las ideas, tan golpeada por la historia dominante del pensamiento filosófico, arroja luz sobre eso que tanto ha dado qué decir dentro de nuestra filosofía y reposiciona la dignidad de nuestro mundo.
Comportamiento reológico de las gomas extraídas de las semillas de flamboyán (Delonix regia), pixoy (Guazuma ulmifolia) y leucaena (Leucaena leucocephala): ingredientes de uso como aditivos, potenciales, en los alimentos
Authors: Ramírez-Ortiz María Eugenia , Corzo-Ríos Luis Jorge , Rodríguez-Canto Wilbert José , Betancur-Ancona David , Chel-Guerrero Luis
Published: November 2023

Las gomas o hidrocoloides son ingredientes importantes en la industria alimentaria por su empleo como espesantes, estabilizantes, gelificantes y para mejorar la textura en los alimentos. En este estudio, se evaluó el comportamiento reológico de las gomas extraídas de las semillas de flamboyán (Delonix regia), de pixoy (Guazuma ulmifolia) y de leucaena (Leucaena leucocephala) a distintas concentraciones. Se determinaron las curvas de flujo y de viscoelasticidad de las dispersiones de las gomas en agua al 0.5, 1.0 y 1.5%, y se ajustaron a distintos modelos matemáticos. En las tres gomas, a bajas concentraciones, el modelo matemático que mejor describió el comportamiento reológico fue el de la ley de la potencia y en altas concentraciones el comportamiento fue mejor descrito por el modelo de Cross. La viscosidad disminuyó al incrementarse la velocidad de cizallamiento y los valores del índice de flujo (n) indicaron un comportamiento reofluidizante (n<1) para todas las concentraciones evaluadas. Los valores del índice de consistencia (K) fueron más altos para las dispersiones de la goma de pixoy (0.71-1.79) comparadas con las otras gomas (0.10-0.61) en todas las concentraciones estudiadas. En la goma de pixoy el módulo elástico fue mayor que en el módulo viscoso con una ligera dependencia a la frecuencia, esto está asociado con un comportamiento tipo gel, en las de flamboyán y leucaena el tipo de comportamiento fue el de una solución macromolecular.
Mechanism of Formation of Smog and some Adverse Effect of Smog on Environment and Human Being
Authors: Dhanraj  , Meena Ram Bilas
Published: November 2023

Abstract: The formation of smog is a complex chemical process with significant implications for the environment and human health. This phenomenon primarily results from the interplay of various reactants and products, with its origins tracing back to specific sources. The key contributors to photochemical smog include nitrogen oxides, hydrocarbons, and the energy source that drives the reaction—sunlight. Notably, pollutants like nitrogen oxides and hydrocarbons are byproducts of fossil fuel combustion, primarily emitted from coal-fired power plants and various energy production facilities. Additionally, volatile organic compounds (VOCs) are generated when fossil fuels undergo incomplete combustion, as observed in activities like backyard burning and wood-burning stoves. Smog, characterized by a blend of airborne pollutants, poses significant threats to both human well-being and the environment. It can lead to a range of health issues, including respiratory difficulties, asthma exacerbation, heightened susceptibility to lung infections and colds, and eye irritation.
Handling Unstructured Image using Generative AI and Dev-Ops
Authors: Ghawate Prof. S. B. , Falak Prof. D. L. , Chakka Kaushikram , Jagtap Mrunmayee , Dhariwala Murtaza , Falke Abdullah
Published: November 2023

Abstract: The integration of Generative AI and DevOps is revolutionizing the transformation of unstructured medical image data, specifically X-ray images, into structured, actionable information. This groundbreaking approach ensures efficient, accurate, and scalable data conversion, eliminating the need for AI technology. By leveraging innovative methodologies and DevOps practices, we streamline the entire process, offering healthcare professionals enhanced diagnostic capabilities, reduced processing times, and fortified data security. This transformation represents a significant advancement in modern radiology, empowering healthcare providers with the means to make informed decisions and elevate the quality of patient care.
A Comparative Study of Network Simulators
Authors: Kadam Sakshe , More Piyush , Jaiswal Dr. R. C.
Published: November 2023

A network simulator is a tool that can simulate and analyze the behavior of computer networks. They are widely used by the research community to test and evaluate the performance of networks in a virtual environment before deploying them in the real world. The simulators allow the users to test the network without the need to physical hardware or any real time connections. We have studied and compared the detail features of the Network Simulators including the Qualnet simulator which we have implemented in our college.
Smart Grid Simulation with LEACH (Low-Energy Adaptive Clustering Hierarchy) Clustering
Authors: Sakharkar Gourav
Published: November 2023

Power industry applications for smart grid are quite promising. In recent years, network life extension has attracted a lot of study attention. By examining the business needs of the Smart grid, this study enhances the wireless sensor network LEACH algorithm. To ensure the rationality of the cluster head selection, the remaining energy and node density are first taken into consideration. The cluster radius of various sizes is then constructed while clustering using a non-uniform clustering process. To achieve the goal of balancing the energy load, data is transmitted to the base station using the multi-hop mode, and the distance between the cluster head nodes and the remaining energy are utilised as the selection criteria for the next-hop relay node. In order to provide the computational intelligence required to create the Smart Grid, this paper discusses the future of the electric energy system, covering every aspect from power generation to substations, distribution, and customer feedback loops.
Solar Energy Uses and its Applications for Futuristic Energy Requirements
Authors: Kumar Dr. Yogesh , Meena Dr. Shyam Kumar
Published: November 2023

Renewable energy is a solution of current and futuristic energy requirement for environment friendly development. The aim of this article is to aware people from solar energy in various felid like solar fuel, solar building, solar electricity, solar cooking, solar agriculture, solar architecture etc so reduces dependency from fossil fuel. I
IoT Based Smart Home Automation System
Authors: Swathi Mrs. K.
Published: November 2023

The aim of this project is to control the lights, fans and detecting of fire and gas leakage at home using the IoT Blynk cloud platform, an ESP32, and an L298N motor driver. By doing so we can enable remote control of these devices, providing greater convenience and flexibility for the end-user. The ESP32 will act as the central hub of the project, receiving and processing data from the Blynk cloud platform. The L298N motor driver will be used to control the lights and fans, with the ESP32 sending signals to the driver to turn the devices on or off as required.
Theological Pluralism: Exploring Religious Expressions within The Baha'i Community in Kubu Raya
Authors: Hidayat Samsul , Sulaiman Sulaiman
Published: November 2023

This research illustrates the vulnerability experienced by contemporary society in practicing religious beliefs, necessitating the emergence of Theological Pluralism as a new innovation to provide space for minority communities such as the Baha'i to express their religious beliefs. The objective of this study is to elucidate the expressions and responses of the community towards the Baha'i community in Kubu Raya, viewed through the lens of Theological Pluralism. The research employs a qualitative approach rooted in sociology, incorporating literature review and field research. Data collection methods include observation, previous research, and relevant data pertaining to this study. This study indicate that the Baha'i community expresses its beliefs through social interactions viewed from the perspective of Theological Pluralism, ultimately fostering attitudes of tolerance, inclusivity, and appreciation for diversity within pluralistic societies. The community's response to the Baha'i varies, with some exhibiting positive acceptance and others displaying negative rejection. Factors influencing these responses involve limitations in religious knowledge and the socio-political dynamics impacting religious domains.