bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Akuntansi Sumber Daya Manusia Terhadap Kinerja Keuangan Pada PT Bank Syariah Indonesia Tbk Tahun 2017-2022
Authors: Juendi  , Suciyati Amna Luke
Published: November 2023

Tujuan dari penelitian ini adalah untuk membandingkan bagaimana PT. Bank Syariah Indonesia Tbk. menggunakan Akuntansi Sumber Daya Manusia (ASDM) dan nilai Sumber Daya Manusia sebelum dan sesudah Akuntansi Sumber Daya Manusia diberlakukan (ASDM). Penelitian yang merupakan jenis penelitian kualitatif ini menggunakan perbandingan neraca, laporan laba rugi, dan rasio keuangan sebelum dan sesudah menerapkan HR Accounting sebagai pendekatannya. Teknik analisis data yang digunakan dalam penelitian ini membandingkan prediksi yang dibuat sebelum dan sesudah penerapan akuntansi sumber daya manusia (ASDM). Temuan penelitian menunjukkan hal itu (1) Kreditor dan investor dapat melihat investasi terbesar dalam perusahaan dengan menggunakan PT. penilaian SDM Bank Syariah Indonesia Tbk dengan menggunakan Human Resource Accounting (ASDM); (2) perbandingan rasio keuangan yang terdiri dari kenaikan Net Profit Margin, kenaikan Return On Equity, kenaikan Return On Assets, dan kenaikan Inc. Dengan demikian, penggunaan Human Resource Accounting (ASDM) memiliki potensi untuk meningkatkan PT. kinerja Bank Syariah Indonesia Tbk. dan memiliki pengaruh yang cukup positif.
Effect of Crop Establishment Method and Fertilizer Management on Yield Performance of Boro Rice (Var. Brri DHAN28) In T. Aman-Mustard-Boro Rice Cropping Pattern
Authors: Khan MLK , Ali MA , Paul SK
Published: November 2023

The Study was carried out at the Salpoborian village under Sadr papilla of Mymensingh from February to June 2014 to assess the effect of crop establishment method and fertilizer management on the yield performance of Boro rice (var. BRRI dhan28) in T. Aman-Mustard-Boro rice cropping pattern. The experiment comprised three crop establishment methods viz. traditional puddled-transplanting (TPT), unpuddled-one pass in dry condition (UDC), unpuddled-zero tillage (UZT) and five levels of fertilizers viz., 100-60-40-60-10 N-P-K-S-Zn kg ha-1 at recommended (RD) dose (F1), N-K-S-Zn at RD plus 50% P (F2), N-P-S-Zn at RD plus 50% K (F3), P-K-S-Zn at RD plus 75% N as Guti urea (2.7 g/4 hills) (F4), P-K-S-Zn at RD plus 75% N as pilled urea (F5). The experiment was laid out in a split -plot design with 4 replications with crop establishment method in the main- plots and fertilizer management in the sub-plots. Grain yield was not significantly influenced by crop establishment method, fertilizer management and their interactions. However, numerically the maximum grain yield of  3.19 t ha−1  was found in both unpuddled-one pass in dry condition (UDC) and unpuddled-zero tillage (UZT) with  3.32 t ha−1 in P-K-S-Zn at RD plus 75% N as pilled urea (F5) and 3.47 t ha−1 in unpuddled-one pass in dry condition with P-K-S-Zn at RD plus 75% N as pilled urea and traditional puddled-transplanting with P-K-S-Zn at RD plus 75% N as pilled urea. Similar higher gross margin (Tk. 26629 and Tk. 27428) and benefit cost ratio (1.61 and 1.60) was also observed in UZT × F4 and UDC × F5, respectively. So, it can be concluded that unpuddled-zero tillage with P-K-S-Zn at RD plus 75% N as Guti urea (UZT × F4) and unpuddled-one pass in dry condition with P-K-S-Zn at RD plus 75% N as prilled urea (UDC × F5) is the beneficial technique for Boro rice (var. BRRI dhan28) cultivation in T. Aman-Mustard-Boro rice cropping pattern.

Bangladesh Agron. J. 2023, 26(1): 32-39
Influence of Agronomic Managements on Growth and Yield of Boro Rice
Authors: Roy JC , Biswas PK , Islam MS , Mahmud MH
Published: November 2023

The study was carried out at Sher-e-Bangla Agricultural University, Dhaka from December 2018 to April 2019, to find out the agronomic practices on the growth and yield of Boro The trial was conducted with two rice varieties namely V1 (BRRI dhan84) and V2 (BRRI hybriddhan5), and 5 different agronomic practices such as M0 (no management), where variety in maim-plot and management practices in sub-plot. The results showed significant variations in weed severity, and l yield of Boro rice. Specific observations included plants reaching heights of 24.81 cm, 51.56 cm, 86.71 cm, and 119.21 cm at 20, 45, 70 days after transplanting (DAT), and at harvest, respectively. V2 exhibited a higher grain yield (5.36 t ha−1) but a reduced straw yield (4.97 t ha−1) compared to V1. Generally, regardless of the agronomic practices, BRRI dhan84 exhibited greater plant height, except under the 'no management' practice. The grain yield (6.70 t ha−1) was obtained with M6, and the maximum straw yield (6.55 t ha−1) to M4. The interaction effects showed that highest grain yield (7.35 t ha−1) from V2M6, while with V1M0.The most significant yield reduction for BRRI dhan84 was 84% with no management and 80% with no fertilizer, while BRRI hybriddhan5 showed a 71% reduction under similar conditions.

Bangladesh Agron. J. 2023, 26(1): 104-111
Effect of Fertilizer on the Growth and Yield of Boro and T. Aman Rice in the Soils of Industrially Polluted Agricultural Land Areas of Madhupur
Authors: Huda MN , Masum SM , Mollick MOA , Khan MA
Published: November 2023

A pot experiment was conducted during 2018-19 in a net house at the Department of Soil Science, Sher-e-Bangla Agricultural University, Dhaka, to determine fertilizer's effect on the growth and yield of Boro and T. Aman rice in the soils of industrially polluted agricultural land areas of Madhupur Tract. The study consisted of two factors, i.e., polluted soil viz., S1: Non-polluted soil, S2: polluted soil-1, S3: polluted soil-2, S4: polluted soil-3, and four fertilizer treatments viz., T0: Control, T1: N150P30K60S20Zn3.0 (100%RDCF), T2: N105P21K42S14Zn2.1 (70%RDCF) T3: N75P15K30S10Zn1.5(50%RDCF) The experiment was laid out in a Randomized Complete Block Design (RCBD) with three replications. Among the soils, the highest Boro rice grain yield of 90.83 g pot-1 was found in S2 (polluted soil-1) soil, and the lowest 41.66 g pot-1 in soil S1 (Non-polluted soil). The treatment T3(50% RDCF) fertilizer treatment gave the highest plant height (84.12 cm), effective tillers (42.5 hill–1), straw (112.58g pot –1) and grain yield (80.03g pot−1) of Boro rice. The higher grain and straw yields of Boro rice were obtained from two industrially polluted soils (S2 and S4). The maximum   grain yield (112.3g pot–1)  of Boro was  found in S2T3 (Contaminated soil 1 and 50% RDCF) , which was statistically similar to S4T2 and S4T3  and lowest in the S1T0 treatment combination. The maximum  T. Aman grain yield (38.75gpot−1) was obtained in soil S2 (polluted soil-1), which at par  to S4 (polluted soil-3). The maximum  T. Aman rice grain yield (36.68 g pot−1) was found in the T2 treatment, which was closely by  T1 treatment. Similarly, the maximum  T. Aman grain yield was obtained in S2T1 (Contaminated soil 1 and 100% RDCF)  which was statistically similar to S2T2, S4T1, and S4T2  and lowest in the S1T0 treatment combination. The highest T. Aman straw yield was found in the S3T1  and lowest in the S1T0 treatment combination.

Bangladesh Agron. J. 2023, 26(1): 112-121
Yield Performance of Chia (Salvia Hispanica L.) In Response to Planting Spacing and Npk Fertilizers
Authors: Rahman Md Moshiur , Haque Md Ariful , Anwar Md Parvez
Published: November 2023

Optimization of plant spacing, and fertilizer dose is very important for realizing maximum yield of a crop. An experiment was conducted at the Agronomy Field Laboratory of Bangladesh Agricultural University, Mymensingh during November 2020 to March 2021 to determine the effect of different spacing and NPK fertilizer levels on yield and yield attributes of chia seed. The experiment consisted of four different spacing viz. 30 cm × 15 cm (S1), 30 cm × 30 cm (S2), 40 cm × 15 cm (S3) and 40 cm × 30 cm (S4) and five levels of NPK fertilizer viz. No NPK (F0), 30: 20: 25 kg NPK ha-1 (F1), 60: 40: 50 kg NPK ha-1 (F2), 90: 60: 75 kg NPK ha-1 (F3) and 120: 80: 100 kg NPK ha-1 (F4). The experiment was laid out in a factorial randomized complete block design (RCBD) with three replications. The results revealed that 40 cm × 30 cm spacing produced the highest number of inflorescences plant-1, seed yield and haulm yield. The fertilizer level 90: 60: 75 kg NPK ha-1 showed the highest seed yield and haulm yield while 120:80 :100 kg NPK ha-1 exhibited the maximum number of inflorescences plant-1. The combination of 30 cm ×30 cm spacing and 90: 60: 75 kg NPK ha-1 produced the highest number of inflorescences plant-1 and seed yield whereas the combination of 40 cm × 30 cm spacing and 90: 60: 75 kg NPK ha-1 had the highest haulm yield. The present study concluded that cultivation of chia at a spacing of 30 cm × 30 cm and fertilized with 90: 60: 75 kg NPK ha-1 could be considered as the promising practice for reasonable seed yield.

Bangladesh Agron. J. 2023, 26(1): 122-127
Evaluation of the efficacy and safety of intralesional 5- fluorouracil in keloid
Authors: Khatun Masuda , Sayed M M Abu
Published: November 2023

Background: Keloid is an area of overgrowth of fibrous tissue that usually develops after healing of skin injury and extends beyond the original defect. The existing treatment modalities include intralesional steroids, cryotherapy, silicone gel sheets, verapamil and 5- fluorouracil (5-FU).

Methods: An open label study on 48 keloids in 35 subjects attending the Department of Dermatology in Dhaka Medical College Hospital during June 2017 and November 2017. Patients with keloids of 10cm and less along the longest diameter in the age group 18-75 years, Keloids with signs of infection, History of hypersensitivity and/or intolerance to 5- FU were included in the study.

 Results: Majority 21(60.0%) patients had single site keloid and 14(40.0%) had multiple site keloid. Majority 54.3% patients had keloids size 2-5 cm. All patients had pain and hyperpigmentation, 5(14.3%) had pustules, 3(8.6%) had necrosis and 1(2.9%) had ulceration. The median keloid area before the treatment was 4 with an inter quartile range of 1.5 to7.8 and this is compared with post treatment area, median 1.5 and inter quartile range 0.6 to 4. Wilcoxon signed rank test was used to assess the reduction in the size of keloid before and after treatment which was significant (P<.001).

Conclusion: Majority patients had single site keloid. All patients had pain and hyperpigmentation. low dose intralesional 5-FU is safe and effective modality in the treatment of keloids.

Journal of Paediatric Surgeons of Bangladesh (2016) Vol. 7 (2): 46-49
Nova Turco-Samoiedica
Authors: Ünal Orçun
Published: November 2023

The present paper focuses on the lexical contact between Turkic and Samoyedic and discusses nine new possible Turkic loanwords in Proto-Samoyedic and eight new possible Samoyedic loanwords in Turkic. The introduction offers a modest bibliography of the scattered studies on the subject. Two of the new Turkic loanwords in Proto-Samoyedic suggest that they reached the recipient language through the mediation of Yeniseian languages.
On adverbial clauses in Udmurt
Authors: Georgieva Ekaterina
Published: November 2023

This paper presents three types of non-finite adverbial clauses in Udmurt: the ones encoded with the suffixes -(e)mja, -(o)nja, and -(o)ńńa. I propose that these suffixes should be decomposed morphologically and that these non-­finite adverbial clauses are to be analyzed as postpositional phrases. In this way, the paper contributes to the analysis of non-finite adverbial subordination in Udmurt. Moreover, the description of -(o)ńńa-clauses in the Middle Cheptsa dialect, which have not been previously described in the literature, also deepens our knowledge of Udmurt dialectal syntax. Additionally, this study has implications for our understanding of the Udmurt case system, as it makes a novel proposal regarding the adverbial case in Udmurt.
Pembelajaran matematika berbasis Education for Sustainable Development dilihat dari perspektif sikap sosial siswa
Authors: Putra Jaya Dwi , Nurcahyono Novi Andri
Published: November 2023

Abstrak Penelitian ini bertujuan untuk mendeskripsikan hasil pembelajaran matematika berbasis ESD dilihat dari peningkatan sikap sosial siswa. Penelitian ini merupakan penelitian ekperimen, uji coba dilakukan di salah satu SMA di kabupaten lima puluh kota, Propinsi Sumater Barat. Subjek penelitian adalah siswa kelas XI pada SMA yang ditetapkan. Pada penelitian ini digunakan perangkat pembelajaran matematika berbasis ESD, meliputi: Silabus, RPP, bahan ajar, LKS, serta instrumen sikap sosial siswa. Hasil penelitian menunjukkan bahwa pembelajaran matematika berbasis ESD dapat meningkatkan sikap sosial siswa dengan kategori peningkatan sedang.Kata Kunci: Education for Sustainable Development, Pembelajaran Matematika, Kemampuan Berpikir Kritis Matematis, Sikap SosialAbstract This study aims to describe the results of ESD-based mathematics learning seen from improve students' social attitudes. This research is a experiment research, the product trial was conducted in one of the high schools in the district of fifty cities, West Sumatra Province. The research subjects were students of class XI at the designated high school. In this study, an ESD-based mathematics learning device, including: syllabus, lesson plans, teaching materials, worksheets, as well as instruments for students social attitudes. The results showed that ESD-baseed mathematics learning can improve students' social attitudes in the moderate improvement category. Keywords: Education for Sustainable Development, Mathematics, Students Social Attitudes.
A transitivity analysis of the final 2020 presidential debate Donald Trump and Joe Biden
Authors: Halim Nurhaliza , Megah Suswanto Ismadi
Published: November 2023

This study is aimed to determine the ideological content implied in the debate speeches of Donald Trump and Joe Biden by using the transitivity theory of Halliday. The method used is descriptive qualitative. From the data found, the highest frequency of process types is found in Donald Trump with a total of 63 (100%), while Joe Biden with 32 times (51%). From this study, it can be concluded that the Transitivity analysis that most often occurs in the Donald Trump and Joe Biden debate is the Material Process. This process is the process of doing something. In this case, Donald Trump and Joe Biden took action in dealing with coronavirus cases in America. Donald Trump and Joe Biden's ideological stance is to show that he cares about the coronavirus cases in America. This is done bay both candidates due to show how they have struggled to handle the pandemic very well in order to get sympathy from ten audiences.
Theory and practice of constructive approaches in mathematics learning
Authors: Hanggara Yudhi , Sa'dijah Cholis , Qohar Abdul
Published: November 2023

The purpose of this study is to examine the theory and practice of constructivism in learning mathematics. This research is qualitative research using library research methods. Data was obtained by collecting various literature sources such as books, journals, and online research articles that are appropriate to the research problem. Data analysis in this study was carried out by content analysis. The research results show that teachers need to give students the freedom to experiment and provide relevant contexts for their theory development. In practice, teachers must consider that each student is unique and different in the way they understand and construct their knowledge. Therefore, teachers need to facilitate the learning process by considering the individual differences of students, ensuring that they have useful experiences and gain a deep understanding of the topics being taught.
The effectiveness of the Team Assisted Individualization model assisted by mathematics domino on mathematics learning outcomes of high school students
Authors: Ainun Nurul , Agustyaningrum Nina , Amelia Fitrah
Published: November 2023

This study was inspired by the class X SMA Hidayatullah Batam's poor mathematics learning outcomes, one of which was brought on by teaching strategies that discouraged student participation in the learning process. The purpose of this study was to compare the Team Assisted Individualization learning model assisted by mathematics domino (domat) visualizer with conventinal learning models in terms of the mathematics learning results for class X students at SMA Hidayatullah Batam. This kind of research utilized a posttest-only control group design and was quasi-experimental in nature. Up to 53 pupils from class X at SMA Hidayatullah made up the research population. The experimental class, X MIPA PA (15 students), and the control class, X MIPA PI (15 students), were sampled via purposive sampling. The research instrument was in the form of essay questions where all items were valid and reliable (reliability coefficient 0.927 in the high category). Using one sample t-test and independent sample t-tests the data were analyzed. The results showed: (1) The implementation of the domat-assisted TAI learning model was effective in terms of mathematics learning outcomes with a t-value (4.231) t-table (2.144); (2) the conventional model is ineffective with a t-value (-0.728) ≤ t-table (2.144); and (3) there were differences between the domat-assisted TAI learning model and the conventional model in terms of the outcomes of mathematics learning with a t-value (3.082) t-table (2.048). On the basis of the study's findings, the domat-assisted TAI learning approach is advised as an alternative to learning mathematics. It can help students take an active part in the learning process and improve their learning outcomes.
The effectivenes of blended learning model integrated independent learning on critical thinking
Authors: Erita Selvia
Published: November 2023

The goals and outputs of higher education education are to make students proficient in problem solving, creative, innovative and critical thinking. However, in reality students' critical thinking skills are still low. Therefore the aim of this research is: 1). Reveal the effectiveness of the blended learning model on students' critical thinking skills; 2). Knowing the interaction between blended learning models and learning independence in influencing critical thinking skills. Therefore, the design of this study is a mixed factorial between and within groups (Between Group-Within Group). 42 semester V students of IAIN Kerinci were sampled in this study. Critical thinking skills tests and questionnaires were used in this study which were analyzed quantitatively.  The results showed that the blended learning model was effective in influencing students' critical thinking skills with an average score of 72.3 while the control class's critical thinking skills had an average score of 60.45. In addition, based on the test between subjects effect model, a significance of 0.003 was obtained, Sig 0.05, meaning that there were differences in critical thinking skills between students using blended learning models and using conventional models. In addition, there is a significant interaction effect between independence and students' critical thinking skills.
Hubungan Pembukaan Status HIV Dengan Kondisi Psikososial Pada Anak Dengan HIV Di Jabodetabek
Authors: Trisiswati Maya , Rifqatussadah Rifqatussadah , BK Airindya
Published: November 2023

Pendahuluan. Laporan triwulan 1 tahun 2021 Subdit AIDS dan PIMS Kemenkes ,jumlah kasus  anak (0-14 tahun) 12.420 dengan  usia kurang dari 1 tahun 0,5%, 1-4 tahun 1,7% dan 5 -14 tahun  1,2% . Sejak di temukan ARV harapan hidup Anak dengan HIV ADHA)  meningkat jika patuh minum. Dibutuhkan persiapan  anak bisa mengetahui status HIV agar patuh. Ketidakpatuhan mempercepat masuk ketahap AIDS, infeksi opprtunistik timbul akibat sistim kekebalan tubuh rendah,sakit-sakitan, terganggu tumbuh kembangnya mengalami kematian sebelum masa remaja. Permasalahan HIV AIDS akan berdampak pada masalah psikososial, baik pada ADHA maupun pada keluarganya, karena terjadi kesenjangan antara kebutuhan dan kepuasan ODHA, kesenjangan antara kapasitas dan tuntutan lingkungan dan kesenjangan antara harapan dan situasi yang dirasakan, yang semua ini memicu stress dan depresi dan berakibat pada keengganan mematuhi minum obat. Rasa bosan, rasa dibohongi, rasa diperlakukan tidak adil karena harus terus minum obat sementara anak lain tidak. Metode. Penelitian deskriptif kuantitatif, cross sectional, data  diambil melalui Google Form dari survei online. Hasil. Analisis data responden 111,  laki-laki 74,8% perempuan 25,2%, usia terbanyak 26-45 tahun (84,7%),pekerjaan terbanyak ibu rumah tangga 38,7%, Domisili terbanyak di Jakarta (43,2%), Anak Responden ADHA perempuan  dan laki-laki (57,7% dan 42,3%), usia terbanyak 11-14 tahun (51,4%) pendidikan  SD. Dampak psikosoisal anak sedih (37,8%), biasa saja (30.6%) dan bingung (27 %). Uji chy Square p= 0,036 untuk hubungan pembukaan status dengan reaksi psikososial.. Kesimpulan. Ada hubungan bermakna  pembukaan status dengan reaksi psikosoial anak, , karena  p= 0,036 atau p < 0.05
IMPLEMENTASI PENGGUNAAN ALAT EDUKASI KARTU BERGAMBAR (FLASH CARD) DALAM MENINGKATKAN KEMAMPUAN BAHASA INGGRIS SISWA
Authors: Lubis Muya Syaroh Iwanda , Rahim Rani , Nasution Asrindah , Nurhayati Nurhayati , Anggraini Putri , Sartika Dwi
Published: November 2023

Students' interest in learning English is still low, which means students' English language skills are also low. This is because during the learning process in the classroom, teachers do not use learning media such as educational tools. Educational tools are very important if applied in learning. This is because educational tools can increase students' learning motivation so that learning is more meaningful, innovative and creative. Therefore, the service team carries out service activities regarding the use of educational tools in classroom learning. This service activity aims to increase students' interest in learning and also students' English language skills. This service activity was carried out at MIS Nurul Hidayah Medan. Participants in this activity were class V students consisting of 30 students. This activity will be carried out on September 6 2023. This activity will be carried out in 3 stages. The first stage is to give a pretest to students before carrying out implementation activities using picture card educational tools (flash cards). The second stage is implementing the use of flash cards in English lessons. The third stage is giving a posttest to students after carrying out implementation activities using picture card educational tools (flash cards). The results of this activity were that the student response was very good and students were more interested in learning using the flash card educational tool and there was an increase in student ability obtained from the N-Gain score which was in the medium category. So it can be concluded that the flash card educational tool can improve students' English language skills.
PEMANFAATAN PLATFORM MARKETPLACE UNTUK EKSPANSI BISNIS UMKM LOKAL
Authors: Fatmawati Fatmawati , Khasanah Siti Nur , Narti Narti , Maruloh Maruloh
Published: November 2023

The use of information technology in Gelam Jaya MSMEs has been used daily. However, restrictions on the use of information technology, especially the use of social media and marketplaces for business expansion, are still very passive.. Activity devotion to public this is very important remember the vital role of MSMEs in economy local. MSMEs often face challenge in promote product they in a way wide . Utilization of marketplace platforms can help local MSMEs to achieve more market share big , increase sales , and increase Power competitive they in the digital era. The purpose of activity This that is, to give training and support technical to local MSMEs so that they can leverage marketplace platforms to scale sale products and services they teach local MSMEs about importance digitalization in operate business them and give necessary skills in operate online . The activity method used in devotion This with method presentation material in a way direct with provide tutorials to participants . With held activity devotion public this is a local MSMEs can grow and develop , give contribution positive for the economy local , as well create impact positive social for owner business and society local. Activity This in line with efforts to strengthen Power MSME competitiveness in the digital era and promote economy local , sustainable.
Updated national guidelines for spirometry. Part 1. Test rules and quality criterias
Authors: Kameneva M. Yu. , Kiryukhina L. D. , Struchkov P. V.
Published: November 2023

Improved approaches to quality assurance have led to the need to update the technical standards of spirometry taking into account modern technical capabilities. The aim of the study is to present updated recommendations on spirometry with explanations and additions that are important for everyday work in practical healthcare. Analysis of documents on technical standards of spirometry developed by an joint task force of specialists with expertise in conducting and analyzing lung function tests and ensuring laboratory quality, appointed by the Russian Respiratory Society, the Russian Association of Functional Diagnostics Specialists, the Russian Scientific Medical Society of Therapists, as well as a joint group of the American Thoracic Society and the European Respiratory Society. The 1st part presents sections on indications and contraindications to spirometry; technical conditions of the procedure, including infection control; methods of spirometry; describes the main indicators and criteria for the quality of the study. The implementation of the presented standards and consensus recommendations for clinicians, operators and researchers is necessary for improving the accuracy of spirometric measurements and the patient experience.
Analysis of the effect of intensive therapy of premature infants on the development of neonatal retinopathy
Authors: Lopatin A. I. , Andreev V. V. , Pasatetskaya N. A. , Sokolova M. G. , Lopatina E. V.
Published: November 2023

Retinopathy of prematurity is one of the most severe diseases that lead to permanent blindness from early childhood. The frequency of retinopathy of prematurity in neonatology closely correlates with the degree of maturity of the child’s body.

Goal. To conduct a analysis of the correlation of the degree of oxygenation, the number of blood transfusions with the severity of progressive retinopathy in newborns. The study included 40 premature infants diagnosed with retinopathy of newborns who were being treated in the neonatal intensive care unit. Conducted: clinical and diagnostic examination of patients; analysis of the dependence of the degree of oxygenation, the number of blood transfusions, gestational age, inotropic support and the severity of retinopathy.

Materials and methods. Out of 40 patients diagnosed with neonatal retinopathy, 6 children were operated on.

Results and discussion. The study showed that all the operated children were born at a gestation period of less than 29 weeks, were treated with antibacterial and inotropic drugs. There was no direct relationship between the number of blood transfusions and the risk of developing a severe form of the disease with further surgical treatment. In 40% of cases, children who developed retinopathy of stages 1 and 2 did not receive transfusion of erythrocyte suspension at all. At the treatment stage, all operated patients received a gas-air mixture with an oxygen content above 45%, as well as inotropic and vasopressor support with epinephrine and norepinephrine. Statistical analysis has shown that the number of blood transfusions is not the leading factor in the decision to refer a child for surgery. Among children with a gestation period of less than 29 weeks, retinopathy of varying severity was found in all infants; in the group of children aged 30–35 weeks, the disease developed only in 45% of patients.

Conclusion. The conducted studies have shown that the parameter number of hours spent using IVL (the parameter artiﬁcial lung ventilation) is informative, and parameters such as weight and gestational age are signiﬁcant.

It is necessary to note the importance of additional parameters. Among the operated children, the condition of severe asphyxia was suffered by 45.5% of children in group A, in Weight groups severe asphyxia was in 28% of cases. Statistical analysis showed that children who required surgical treatment received catecholamine therapy at the initial stages. The most unfavorable percentage of oxygen supplied with the air mixture starts from 40–45%. The children who required surgical treatment received catecholamine therapy at the initial stages.
Reexaminando la “paradoja del desarrollo fronterizo” del norte de México: ¿mayores ingresos con rezagos en servicios públicos?
Authors: Peláez Herreros Óscar , Castañeda Nava Fidel
Published: November 2023

The objective of this paper is to verify if the urban population of the municipalities of the northern border of Mexico hashigher incomes than those of other municipalities in the country, while suffering worse living conditions; that is what someauthorshave called “border development paradox”. To verify this issue, proportions were compared based on multidimensional poverty data from Conevalfor the period2008-2020,and more municipalities and population were considered than in any previous research. The results show that urban residents of the northern border have higher incomes, but also better access to services and less social deprivation.These results—which contradictsome previous research,but confirm others—are maintained throughout the entireperiod analyzed and with different territorial groups. Therefore, it is concludedthat there is no evidence of said paradox.
Long term follow-up of refractory/relapsed hairy cell leukaemia patients treated with low-dose vemurafenib between 2013 and 2022 at the Department of Internal Medicine and Oncology, Semmelweis University
Authors: Ferenczi Kata , Nagy Zsófia Flóra , Istenes Ildikó , Eid Hanna , Bödör Csaba , Timár Botond , Demeter Judit
Published: November 2023

Introduction: Hairy cell leukemia (HCL) is an indolent B-cell lymphoproliferative disease. BRAF V600E mutation is detected in nearly all classical HCL cases which offers the possibility of targeted therapy.

Objective: The aim of our study was to assess the efficacy of low-dose vemurafenib as well as to assess the long term outcome of HCL patients treated with this drug at the Department of Internal Medicine and Oncology at Semmelweis University.

Methods: We report on 10 patients with classical HCL treated with low-dose vemurafenib at our Department between 2013 and 2022.

Results: As a result of fixed time low-dose vemurafenib treatment, 5 of 10 patients (5/10) achieved partial remission, 4 (4/10) had stable disease, and 1 (1/10) had MRD positivity. No patients achieved complete remission. The median progression-free survival was 28.5 months while the overall survival was 82 months.

Conclusion: We confirm that low dose of vemurafenib is effective and safe in the vast majority of patients with HCL. This small-molecule oral treatment allows to gain valuable time—months or even years—before further, usually parenteral treatment options have to be given or before previous treatment has to be repeated. There are also promising data supporting the combination of vemurafenib with other drugs for the treatment of HCL patients which could provide even further possibility to bridge treatment.
Association of Mitochondrial Variants with the Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto’s Thyroiditis
Authors: Zeber-Lubecka Natalia , Kulecka Maria , Suchta Katarzyna , Dąbrowska Michalina , Ciebiera Michał , Hennig Ewa E.
Published: November 2023

Background. The prevalence of Hashimoto’s thyroiditis (HT) among women with polycystic ovary syndrome (PCOS) is higher than in the general female population, but the factors predisposing to the coexistence of these disorders remain unclear. This study employed whole genome sequencing of mitochondrial DNA to identify genetic variants potentially associated with the development of PCOS and HT and predisposing to their joint occurrence. Results. A total of 84 women participated, including patients with PCOS, HT, coexisting PCOS and HT (PCOS + HT) and healthy women. Both Fisher’s exact and Mann–Whitney U statistical analyses were performed to compare the frequency of variants between groups. Ten differentiating variants were common to both analyses in PCOS + HT vs. PCOS, one in PCOS + HT vs. HT, and six in PCOS + HT vs. control. Several variants differentiating the PCOS + HT group from PCOS and controls were identified, located both in the mitochondrial genes (including the MT-CYB, MT-ND1, MT-ND2, MT-ND4, MT-ND6, MT-CO1, MT-CO3) and the D-loop region. Only two variants differentiated PCOS + HT and HT groups. One variant (13237a in MT-ND5) was common for all three comparisons and underrepresented in the PCOS + HT group. Functional enrichment analysis showed 10 pathways that were unique for the comparison of PCOS + HT and PCOS groups, especially related to ATP production and oxidative phosphorylation, and one pathway, the NADH-quinone oxidoreductase, chain M/4, that was unique for the comparison of PCOS + HT and control groups. Notably, nine pathways shared commonality between PCOS + HT vs. PCOS and PCOS + HT vs. control, related to the biogenesis and assembly of Complex I. Conclusion. This study provides novel insights into the genetic variants associated with oxidative stress in women with coexisting PCOS and HT. Mitochondrial dysfunction and oxidative stress appear to play a role in the pathogenesis of both conditions. However, more mitochondrial variants were found to differentiate women with both PCOS and HT from those with PCOS alone than from those with HT alone.
Probing the Proton-Gated ASIC Channels Using Tetraalkylammonium Ions
Authors: Evlanenkov Konstantin K. , Nikolaev Maxim V. , Potapieva Natalia N. , Bolshakov Konstantin V. , Tikhonov Denis B.
Published: November 2023

The action of tetraalkylammonium ions, from tetrametylammonium (TMA) to tetrapentylammonium (TPtA), on the recombinant and native acid-sensing ion channels (ASICs) was studied using the patch-clamp approach. The responses of ASIC1a, ASIC2a, and native heteromeric ASICs were inhibited by TPtA. The peak currents through ASIC3 were unaffected, whereas the steady-state currents were significantly potentiated. This effect was characterized by an EC50 value of 1.22 ± 0.12 mM and a maximal effect of 3.2 ± 0.5. The effects of TPtA were voltage-independent but significantly decreased under conditions of strong acidification, which caused saturation of ASIC responses. Molecular modeling predicted TPtA binding in the acidic pocket of closed ASICs. Bound TPtA can prevent acidic pocket collapse through a process involving ASIC activation and desensitization. Tetraethylammonium (TEA) inhibited ASIC1a and native ASICs. The effect was independent of the activating pH but decreased with depolarization, suggesting a pore-blocking mechanism.
Accounting for the Concreteness and Neighborhood Effects in a High Frequency Word List for Poor Readers
Authors: Tan Amanda Swee-Ching , Ali Farhan
Published: November 2023

Some poor readers show little or no progress in literacy interventions as their susceptibility to the concreteness and neighborhood effect is not accounted for during intervention. This study aims to develop a resource for poor readers by revising the Dolch list to account for the concreteness and neighborhood (orthographic, phonological and semantic) effect. Psycholinguistic techniques were employed to recategorize 220 Dolch list words according to concreteness via function and content word categories, and include the associated orthographic, phonological and semantic neighbors of each word into a new High Frequency List with Neighbors (HFLN). One-way analysis of variance (ANOVA), Bonferroni post hoc test and Levene’s test of variance homogeneity were carried out as measures of statistical significance and variability. The HFLN contains a total of 220 words with 1057 neighbors across five function and content word categories. Both measures of statistical significance and variability show that grade categories in the Dolch list contain greater mean concreteness values with overlapping similarities and higher variability. Conversely, the HFLN effectively delineates concreteness value clusters between categories with lower variability. The HFLN aids in targeted intervention of poor readers by presenting the available orthographic, phonological and semantic neighbors according to the descending order of concreteness.
The Role of Relationships in Resilience: Teachers Who Were At-Risk Youth Supporting At-Risk Students
Authors: Sigad Laura I.
Published: November 2023

Despite extensive research on resilience, little information exists on the resilience of teachers who faced adversity in childhood and the meanings they attribute to their current work with at-risk students. Thus, this study aimed to address this knowledge gap by examining the narratives of teachers who were at-risk children. Based on 30 semi-structured life-narrative interviews, the findings revealed the significant meaning that the participants ascribed to positive relationships. Whether such relationships were present or absent in their childhood, these relationships were instrumental in their choice to pursue a career in education. In supporting their students’ resilience and becoming the teachers they wanted as children, they found meaning in their past experiences of risk and coping. The study’s discussion applies the social mirroring theory to analyze how the participants resisted the negative image presented to them by others in their childhood and how a belief of hopeful prospects fortified them and led them to take on transformative justice as their life mission. Supporting at-risk children functioned as a form of healing for the participants, fostering both their students’ and their own resilience. The study findings highlight the importance of accounting for teachers’ childhood experiences as formative narratives that mold their educational work.
Learning and Motivation When Using Multiple-Try in a Digital Game for Primary Students in Chile
Authors: Cubillos Claudio , Roncagliolo Silvana , Cabrera-Paniagua Daniel
Published: November 2023

The number of attempts to provide students is a key instructional characteristic in computer-based learning (CBL). However, it has not been covered extensively, and there is a need to delve deeper into the factors affecting multiple-try performance and allowing its successful use, including the learner’s involved emotional processes. This study examines the effects of multiple-try on a drill-and-practice mathematical game devoted to primary school students. A total of 73 students from four courses from two schools participated in the experiment. They were randomly assigned to a 3-attempt multiple-try (MTF) and a single-try knowledge of correct response (KCR) conditions. The study covered impacts on learning performance, together with motivation, effort, pressure, and the value of students regarding the learning activity based on the self-determination theory (SDT) perspective and its cognitive evaluation sub-theory (CET). The study’s main findings were that (a) the MTF condition outperformed KCR in terms of students’ learning gains; (b) MTF presented higher levels of perceived competence and autonomy, which, according to SDT, fosters motivation and learning; (c) a cost was yielded in students’ perceived pressure under MTF; and (d) perceived effort and value was similarly high for both conditions despite learning differences. This study complements the existing literature on multiple-try, providing insights into what conditions are beneficial for multiple-try use.
Place, Space, and the Affordances Thereof: Bly Manor as Depicted in Three Adaptations of The Turn of the Screw
Authors: Ekroll Kristoffer S.
Published: November 2023

This paper looks at the representation of Bly Manor across different adaptations of Henry James’s The Turn of the Screw (1898). The focus is on adaptations that emphasize Bly as an intricate space that limits the possibilities of actions that the main characters have. The theory of affordance states that places “afford” different uses of the space. Locked inside a place with uneasily determined affordances and clearly established rules, the main characters of these adaptations experience how different intersections of identities are afforded differently within the stately home. The paper traces the intertextual conversation through adaptations such as Jack Clayton’s film The Innocents (1961), the readaptation of James’s premise in Ruth Ware’s novel The Turn of the Key (2019), before ending with the intertextual and temporal dimensions of haunted space in Mike Flanagan’s streaming miniseries The Haunting of Bly Manor (2020). These iterations of the story showcase the voyeuristic elements of Bly as the characters are repeatedly watched by those who have come before them. At the same time, they show the ongoing appeal of James’s story as its legacy continues into the twenty-first century.
Deep Learning Techniques and Imaging in Otorhinolaryngology—A State-of-the-Art Review
Authors: Tsilivigkos Christos , Athanasopoulos Michail , Micco Riccardo di , Giotakis Aris , Mastronikolis Nicholas S. , Mulita Francesk , Verras Georgios-Ioannis , Maroulis Ioannis , Giotakis Evangelos
Published: November 2023

Over the last decades, the field of medicine has witnessed significant progress in artificial intelligence (AI), the Internet of Medical Things (IoMT), and deep learning (DL) systems. Otorhinolaryngology, and imaging in its various subspecialties, has not remained untouched by this transformative trend. As the medical landscape evolves, the integration of these technologies becomes imperative in augmenting patient care, fostering innovation, and actively participating in the ever-evolving synergy between computer vision techniques in otorhinolaryngology and AI. To that end, we conducted a thorough search on MEDLINE for papers published until June 2023, utilizing the keywords ‘otorhinolaryngology’, ‘imaging’, ‘computer vision’, ‘artificial intelligence’, and ‘deep learning’, and at the same time conducted manual searching in the references section of the articles included in our manuscript. Our search culminated in the retrieval of 121 related articles, which were subsequently subdivided into the following categories: imaging in head and neck, otology, and rhinology. Our objective is to provide a comprehensive introduction to this burgeoning field, tailored for both experienced specialists and aspiring residents in the domain of deep learning algorithms in imaging techniques in otorhinolaryngology.
Treatment of Hyperammonemia Syndrome in Lung Transplant Recipients
Authors: Yun Sarah , Scalia Ciana , Farghaly Sara
Published: November 2023

Hyperammonemia syndrome is a complication that has been reported to occur in 1–4% of lung transplant patients with mortality rates as high as 60–80%, making detection and management crucial components of post-transplant care. Patients are treated with a multimodal strategy that may include renal replacement therapy, bowel decontamination, supplementation of urea cycle intermediates, nitrogen scavengers, antibiotics against Mollicutes, protein restriction, and restriction of parenteral nutrition. In this review we provide a framework of pharmacologic mechanisms, medication doses, adverse effects, and available evidence for commonly used treatments to consider when initiating therapy. In the absence of evidence for individual strategies and conclusive knowledge of the causes of hyperammonemia syndrome, clinicians should continue to design multimodal regimens based on suspected etiologies, institutional drug availability, patient ability to tolerate enteral medications and nutrition, and availability of intravenous access.
Genus Culex Linnaeus, 1758 (Diptera: Culicidae) as an Important Potential Arbovirus Vector in Brazil: An Integrative Review
Authors: Reis Lúcia Aline Moura , Pampolha Ana Beatriz Oliveira , Nascimento Bruna Lais Sena do , Dias Daniel Damous , Araújo Pedro Arthur da Silva , Silva Fábio Silva da , Silva Lucas Henrique da Silva e , Reis Hanna Carolina Farias , Silva Eliana Vieira Pinto da , Nunes Neto Joaquim Pinto
Published: November 2023

The genus Culex has 817 species subdivided into 28 subgenera. It has a cosmopolitan distribution, being most abundant in countries with a tropical climate. Understanding the ecology and diversity of viruses circulating in the species of this genus is important for understanding their role as arbovirus vectors in Brazil. To conduct an integrative review to identify the importance of the Culex genus as arbovirus vectors in Brazil. A search was carried out for scientific papers in the PubMed, BVSalud, Patuá-IEC and International Catalogue of Arboviruses: including certain other viruses of vertebrates databases. 36 publications describing arbovirus detections in Culex mosquitoes collected in the field in Brazil were evaluated. A total of 42 arbovirus species were detected, as well as studies analyzing the vector competence of C. quinquefasciatus for the transmission of four different arboviruses. The study of the Culex genus and its role as a vector of arboviruses in Brazil is essential for understanding transmission cycles, with the main aim of reducing cases of human infection. Thus, entomovirological surveillance guides the implementation of actions to detect circulating arboviruses among vectors to anticipate measures aimed at preventing or reducing the risk of arbovirus outbreaks in the country.
Organ Donation Awareness among Family Members of ICU Patients
Authors: Cotrău Petru , Negrău Marcel , Hodoșan Viviana , Vladu Adriana , Daina Cristian Marius , Dulău Dorel , Pantiș Carmen , Daina Lucia Georgeta
Published: November 2023

Background and Objectives: With one of the lowest donation rates in the European Union, Romania faces challenges in organ donation from brain death donors, within an opt-in system. This study aims to measure the attitudes and knowledge of ICU patient’s relatives toward organ donation. Materials and Methods: A descriptive cross-sectional study was conducted in the intensive care unit of the Emergency Clinical County Hospital of Oradea, Romania. A 24-item self-administered questionnaire (N = 251) was used to collect data on knowledge about organ and tissue donation and transplantation, as well as the willingness to donate. Results: A high degree of awareness and willingness for organ donation and transplantation was recorded. The main positive predictor of willingness to donate was the perception of helping others by donating their organs after brain death (β = 0.537, OR = 1.711, p < 0.05), and the main negative predictor was the idea that the whole body should be buried intact (β = −0.979, OR = 0.376, p < 0.01). Conclusions: A basic understanding of organ donation and transplantation and favorable attitudes toward organ donation were registered. Families’ interviews for organ donation consent may be affected due to extreme emotional distress.