bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive Experimental Study on the Gas Breakthrough Pressure and Its Implication for the Reservoir Performance
Authors: Zhang Hengrong , Xiao Lizhi , Wang Min , Ge Xinmin , Hu Xiangyang , Tan Wei
Published: December 2022

It is challenging to interpret the gas breakthrough mechanisms, controlling factors, and its relationships with the reservoir parameters for unconventional reservoirs such as the gas shale, due to the accumulation characteristics of source-reservoir integration. Take the typical marine shale gas of the B field for example, we use the step-by-step (SBS) test to measure the gas breakthrough pressure of the water saturated shales, and investigate the influential factors such as the pore size distribution, mineral composition, and organic geochemical properties. Moreover, the implication of the gas breakthrough capability for the reservoir quality such as the porosity, permeability, the gas content, and the gas occurrence state are addressed. Based on our work, it is observed that the gas breakthrough capability in shale is influenced by many factors. Generally, the gas breakthrough pressure is positively with the amount of ductile minerals such as the clay and the plagioclase, but negatively with the amount of brittle minerals such as the quartz. In addition, the gas breakthrough pressure is decreased with the increase of the pore radius and the specific surface areas. What is more, the influences of geochemical properties on the gas breakthrough capability should not be neglected. Due to the development of organic pores in the kerogen, the gas breakthrough pressure is found to decrease with the increase of the total organic carbon content (TOC) and the residual carbon content (RC). The breakthrough pressure can be used as the significant parameter to indicate the reservoir quality of the shale gas. It is shown that the breakthrough pressure is inversely with the porosity, permeability, the total gas content, and the adsorbed gas content. It is practical and meaningful to measure and estimate the breakthrough pressure for the formation evaluation in shale gas reservoirs.
Ciudad y ficción audiovisual: enfoques para un análisis geográfico
Authors: Manuel Carlos , Gámir Orueta Agustín , Aertsen Víctor
Published: December 2022

Tras comentar algunas de las conexiones existentes entre la ficción audiovisual y la geografía, el artículo se centra en el fenómeno urbano aportando algunas claves que justifican el interés por abordar el análisis de productos audiovisuales –especialmente largometrajes– desde una lectura geográfica y espacial. Sobresalen en este sentido ciertos títulos que, más allá de su sentido narrativo, permiten obtener ideas y puntos de vista sobre rasgos diversos asociados a la complejidad urbana y sus cambios en el tiempo. Además, se destaca la necesidad de reivindicar la ficción audiovisual como documento e información para la memoria urbana, así como las claves existentes en las relaciones que podemos establecer entre localizaciones y lugares diegéticos, de sentido esencial para una lectura geográfica. A este respecto, se destacan varias iniciativas y propuestas metodológicas que reivindican las posibilidades de generar corpus cartográficos a partir de la información espacial contenida en las producciones audiovisuales. Un último apartado se centra en el turismo cinematográfico (screen tourism) y la ciudad como evidencia de las implicaciones que genera la cultura audiovisual. Los anteriores aspectos justifican, en consecuencia, la relevancia del estudio de las producciones audiovisuales, y en particular de las que se desarrollan en entornos urbanos, desde un punto de vista geográfico.
Substitute locations of urban spaces in films shot in Spain: motivations, representations and consequences
Authors: Aertsen Víctor , Manuel Valdés Carlos , Martínez Puche Antonio
Published: December 2022

The objective of the present article is to reflect upon the phenomenon of substitute locations in fiction films, with special focus on Spanish cities. Although the use of one location to stand in for another is a common film practice, it hasn’t received much attention in film studies and related fields. To improve this situation, we start with a brief review of three moments of Hollywood’s history where substitute locations have been central as an industrial practice, cultural debate and promotional strategy, and we propose six parameters that we consider of interest to pursue a detailed analysis of this phenomenon, especially in urban environments. In the second section, we discuss the use of substitute locations in Spanish cities based on the results of a quantitative and qualitative research carried out on 303 films. Finally, as case studies, we focus on examples of substitute locations in films shot in two Spanish cities, Madrid and Alcoy, identifying the main locations and reflecting upon their use in relation to the six parameters proposed in the theoretical framework. Through these different sections, we seek to contribute to a better understanding of the motivations, representations and geographical and economic consequences of this filmic practice.
LEAVS (Aplearedu with Audio Visual): Pembelajaran Berbasis 3 Human Senses untuk Meningkatkan Kualitas Pembelajaran IPA TERPADU Selama Pandemi COVID-19
Authors: Wakhidah Lyca Rahmawati , Ekapti Rahmi Faradisya
Published: December 2022

Munculnya pandemi Covid 19 telah mengubah berbagai tatanan aspek dalam kehidupan. Pendidikan merupakan salah satu aspek yang berdampak paling besar di Indonesia. Masalah yang timbul dalam pendidikan salah satunya ialah dalam sistem pembelajarannya. Terdapat beberapa permasalahan yang dialami oleh peserta didik diantaranya adalah semangat belajar peserta didik pada proses pembelajaran sangat rendah, peserta didik diberikan penugasan terlalu banyak dengan hanya diberikan waktu yang singkat. Dengan munculnya beberapa masalah tersebut muncul sebuah inovasi yakni penggunaan media pembelajaran berupa video pembelajaran dan juga pembuatan peta konsep. Tujuan penelitian ini adalah untuk mengetahui sejauh mana tingkat pemahaman peserta didik pada pembelajaran IPA Terpadu dengan menggunakan video sebagai media pembelajaran. Metode penelitian yang digunakan adalah metode penelitian kuantitatif dengan menyebar angket yang dibagikan kepada peserta didik yang mengikuti pembelajaran daring. Pengaruh signifikansi pada penggunaan video pembelajaran dan juga pembuatan peta konsep terhadap pembelajaran IPA Terpadu secara daring dapat dilihat dari nilai atau hasil hipotesis dengan RHitung > RTabel  dengan nilai RHitung sebesar 0,4296 yang menyatakan H0 diterima atau H1 ditolak sehingga bisa disebut signifikan. Dengan diterapkannya atau digunakannya video pembelajaran dan pembuatan peta konsep diharapkan meningkatkan semangat belajar peserta didik melalui kreativitas yang peserta didik ciptakan, meningkatkan kenyamanan belajar bagi peserta didik, memudahkan peserta didik dalam memahami materi yang dipelajari, membantu peserta didik berpikir lebih dalam, dalam menuangkan idenya.
Kajian Blended Learning Sebagai Alternatif Model Pembelajaran di Masa Pandemi COVID-19
Authors: Febriyana Vera
Published: December 2022

Pandemi COVID-19 mengakibatkan berbagai perubahan salah satunya di bidang pendidikan. Kebijakan pembelajaran jarak jauh (PJJ) atau pembelajaran daring menuntut guru untuk menciptakan inovasi model pembelajaran yang sesuai dengan syarat dan ketentuan yang berlaku. Oleh karena itu, model pembelajaran blended learning hadir sebagai salah satu alternatif model pembelajaran yang dapat diterapkan di masa pandemi COVID-19. Penelitian ini bertujuan untuk mengkaji segala sesuatu yang berkaitan dengan model pembelajaran blended learning, efektifitas penerapan blended learning, serta kelebihan dan kelemahan dalam proses penerapannya di sekolah. Penelitian ini menggunakan jenis penelitian studi kepustakaan (library research) dengan pendekatan literature review. Adapun sumber data yang digunakan yaitu berbagai jurnal ilmiah dan literatur lain yang relevan. Berdasarkan hasil penelitian, model pembelajaran blended learning dinilai sangat efektif diterapkan pada masa pandemi COVID-19 karena dapat meminimalisir tatap muka secara langsung dan melibatkan teknologi yang ada sebagai media pembelajaran. Kelebihannya yaitu lebih fleksibel, efektif, efisien, jangkauan lebih luas, bervariasi, menarik dan mudah diakses. Sedangkan kelemahannya yaitu kurangnya sarana dan prasarana, fasilitas tidak mendukung, kurangnya penguasaan teknologi dan kreativitas sumber daya manusia. Berdasarkan hasil temuan, penulis mengharapkan penerapan model blended learning dapat dijadikan sebagai satu langkah lebih maju bagi perkembangan pendidikan di Indonesia menuju sistem pendidikan yang lebih baik dan modern.
Implementasi Booklet pada Materi Kingdom Fungi dengan Pendekatan Kearifan Lokal Guna Meningkatkan Daya Tarik Peserta Didik dalam Pembelajaran IPA Kelas VIII
Authors: Maulida Azzahro , Sholikhah Anggi Yunita , Soliha Mar'atus
Published: December 2022

Booklet merupakan suatu media pembelajaran dengan penyajian materi yang jauh lebih singkat dibandingkan dengan bahan ajar, sehingga memudahkan peserta didik dalam menyimpan dan membawanya. Pembuatan booklet berbasis kearifan lokal ini dilatarbelakangi oleh kurangnya pengetahuan peserta didik terhadap kearifan lokal yang pada masa kini semakin minim dikaji dalam pendidikan. Selain itu, materi fungi yang berbasis teori, mendukung pembuatan booklet guna meningkatkan daya tarik peserta didik dalam mempelajari materi fungi. Penelitian ini bertujuan untuk menguji validitas booklet pada materi kingdom fungi kelas VIII SMP/MTs dengan menerapkan metode R & D (Research and Development) atau penelitian dan pengembangan, yaitu 3 D (Define, Design, and Develop) di mana tahap tersebut untuk menguji validitas dari booklet. Validitas booklet dilakukan oleh 4 ahli media pembelajaran dan difokuskan pada aspek konten, tampilan, bahasa, penggunaan serta penyajian dari booklet tersebut. Booklet hasil rata-rata nilai validasi 2,96 dan 3,07 dengan kategori baik serta butuh perbaikan, kemudian 3,27 dan 3,34 dengan kategori sangat baik tanpa perbaikan.
Potential drug-drug interactions and associated factors among admitted patients with psychiatric disorders at selected hospitals in Northwest Ethiopia
Authors: Dagnew Ephrem Mebratu , Ergena Asrat Elias , Wondm Samuel Agegnew , Sendekie Ashenafi Kibret
Published: December 2022

Background: Prescribing medications without potential drug-drug interactions (pDDIs) is one of the components of the rational use of medications. However, taking combined medications has resulted in life-threatening pDDIs, which are causing severe clinical outcomes for patients. This study was aimed at assessing the prevalence of pDDIs and associated factors in admitted patients with psychiatric disorders.
Methods: An institution-based multicenter cross-sectional study was conducted among patients with psychiatric disorders admitted to a selected hospital in Northwest Ethiopia. Samples were approached through a systematic sampling method. The Statistical Package for the Social Sciences (SPSS) version 26 was used to analyze the data. Logistic regression was applied to determine the association of variables with pDDIs. A p-value of < 0.05 was statistically significant.
Results: Out of 325 study participants, more than half (52.9%) were females, with a median age of 61 years. Overall, more than two-thirds (68.9%) were exposed to at least one clinically significant, either moderate or major level of pDDIs. Nearly one-fourth (23.2%) of participants had at least one major level of pDDIs. Older patients were found more likely to have pDDIs compared to younger patients (p = 0.043). Similarly, patients with a higher number of prescribed medications (p = 0.001) and patients with longer hospital admissions (p = 0.004) were found more likely to be exposed to pDDIs than their counterparts.
Conclusion: In this study, a significant number of admitted patients with psychiatric problems encountered clinically significant pDDIs. As a result, healthcare providers could assess and follow patients with a combination of medications that potentially have a drug-drug interaction outcome.
Physiological and biochemical contrasting responses associated with growth performances in sunflower seedlings after a cold stress
Authors: Fabio Ernesta , TOMMASINO EXEQUIEL ARTURO , Grieu Philippe
Published: December 2022

In the climate change context, extreme events have become more frequents. Spring is the sunflower sowing season. Late frosts events or several days of low temperatures often occur causing delays in crop growth and even losses in plant density per hectare. Tolerance to low temperatures is an important trait considering that the sunflower production area is expanding to marginal regions with suboptimal growing conditions. Furthermore, an early sowing practice to maximize the sunflower growing period is commonly implemented in Argentina and in others countries. An interesting approach to identifying tolerant genotypes in breeding programs is exploring biochemical and physiological traits involved in growth recovery after cold exposure in sunflower seedlings. In this research, the physiological and biochemical responses of two contrasting sunflower genotypes were evaluated. Commercial hybrids Pampero (PM) and Sierra (SA) were exposed to cold treatment at 5°C for 96 hours. Growth performance, malondialdehyde content, superoxide dismutase and catalase enzyme activities, chlorophyll content and electrolyte leakage were assessed at 0, 24, 48 and 72 hours after the cold treatment. Different patterns between genotypes were observed. The sensitive genotype PM showed higher oxidative damage, lower membrane stability, reduced catalase and reduced superoxide dismutase activities, in contrast with the tolerant genotype. Moreover, tolerant genotype SA showed a great capacity to recover the chlorophyll content and restart growth while the sensitive genotype showed only a slight increase in chlorophyll content and a clear delay in growth.
Treating tibial fracture with supra-cutaneous locking plate osteosynthesis: personalized therapy for special patient;A case series study
Authors: Zhang Chao , Zhang Junyu , Li Hongjian
Published: December 2022

Background The choice of surgical options for open tibial fractures and closed tibial fractures with soft tissue problems has been controversial.Supra-cutaneous locking plate fixation may be able to provide an personalized treatment plan.
Methods After retrospective analysis of the clinical database, we collected data on 19 patients identified as having chronic osteomyelitis after routine surgery for tibial fractures or open tibial fractures.All patients who underwent external fixation with a supra-cutaneous locking plate were followed up for 12.89±3.81 months postoperatively.Further statistical analysis was not performed because the number of cases was too small and the injuries and fracture types were different.
Results The postoperative Fugl-Meyer lower limb motor function score was 32.47±3.34 in 19 operated patients, which was evaluated according to the Mazur ankle scoring system: 11 cases were excellent, 5 cases were good, 2 cases were acceptable, and 1 case was poor, with an excellent rate of 84%. The duration of time that passed between the implantation of the supra-cutaneous locking plate and its subsequent removal ranged from 13.00±1.05 months.
Conclusions In certain tibial patients with specific indications, such as open tibial fractures without significant bone or soft tissue defect, closed tibial fractures with severe blisters or compromised soft tissue condition, and surgical site infections following tibial internal fixation with no significant bone or soft tissue defect, supra-cutaneous locking plate fixation may be used. It offers sufficient biomechanical stability for fracture repair while minimizing the inconveniences associated with bulky circular frames or external fixators.The supra-cutaneous locking plate fixation used as the final treatment may also result in a little shorter hospital stay for these individuals and lower healthcare expenses.
Sustainable project portfolio selection under uncertainty with consider conflicting projects
Authors: Ramedani Amir Mohammad , Mehrabian Ahmad , Didehkhani Hosein
Published: December 2022

Given the complexity of selecting an industrial project portfolio, portfolio project selection (PPS) has been one of the most crucial concerns of project managers. On the other hand, comprehensive evaluation of projects based on multiple criteria and uncertainty causes the complexity of PPS. Therefore, to improve this problem, this study presents PPS considering a synergy of industrial projects with different criteria related to sustainability, time-dependent, resources, budget, and human resource capability in a two-stage decision under uncertainty. In the first stage, according to the review of historical documents, analysis of checklists, consultants, and specialists the criteria are identified. Then, with a multi-criteria decision-making (MCDM) method, it is considered for scoring with Fuzzy Best-Worst Method (FBWM) and ranking with Fuzzy Vlsekriterijumska Optimizacija IKompromisno Resenje (FVIKOR) method and calculating the sustainable utility of projects. In the second stage, a multi-objective fuzzy-robust-stochastic (FRS) optimization model by maximizing the total profit of the project is a value of the sustainable utilization of the project and minimizing the amount of interruption in project implementation. This model has two challenges including multi-objective and complex, thus to solve the mixed-integer linear programming model, a novel hybrid method according to the Multi-Choice Goal Programming with Utility Function (MCGP-UF) with the Genetics Algorithm (GA) is developed. The outcomes of sensitivity analysis by implementing the model in the real world display that the model and approach presented in varies problems have high flexibility.
Applying multi-objective particle swarm optimization-based dynamic adaptive hyperlink evaluation to focused crawler for meteorological disasters
Authors: Liu Jingfa , Yang Zhihe
Published: December 2022

In traditional semantic-based focused crawlers, the topical priority of unvisited hyperlinks is calculated by linearly integrating pre-defined topical similarity evaluation metrics and their corresponding weighted factors. However, these weighted factors are manually determined by personal experience, which may introduce bias in evaluating unvisited hyperlinks, resulting in topic deviation during crawling. To address this problem, we propose a dynamic adaptive focused crawler, denoted by FCMOPSO, based on multi-objective particle swarm optimization (MOPSO). For topic representation, two domain ontologies of meteorological disasters are constructed. Additionally, we present a comprehensive priority evaluation method (CPEM) of hyperlink concerning both webpage content and hyperlink structure. In MOPSO, the weights of metrics of the CPEM can be updated in every crawling iteration. Furthermore, we utilize the non-dominant sorting with the nearest farthest candidate solution (NS_NFCS) to ensure the diversity of crawling hyperlinks and expand the search range. Compared with focused crawler strategies in the literature, the experimental results on domains of rainstorm disaster and typhoon disaster show that our proposed FCMOPSO achieves satisfactory performance that it can obtain more topic-relevant webpages with ideal time consumption.
Early Identification Methods for Emerging Technologies Based on Weak Signals
Authors: Zhan Chuan , du ye
Published: December 2022

To intelligently identify emerging technology research directions at an early stage, this study proposes a method for the early identification of emerging technology directions on the basis of weak signals and explores the effectiveness of the method. With signal combination map theory, the weak signal keywords of emerging technologies are extracted by text mining. An unsupervised learning model (LDA) is used for topic clustering to further improve the signal interpretation ability and identify weak signal topics. A deep learning model (BERT) is utilized to extend the weak signal topics and make the topic directions clear. By applying the method to augmented reality technology and basing on the data of invention patents and scientific studies in this field in the last decade, we identify six research topics with weak signal characteristics in current augmented reality research; these six are architecture, industrial manufacturing and maintenance, medical care, education, and augmented reality contact lenses, which may be the development directions of future augmented reality research. The weak signal topics are then further expanded to clearly show the specific content of these topics in terms of function, domain, and technology while proving that the early identification method is effective and feasible.
Loss of actin dynamics leads to VDAC dependent MAPK signalling and altered lipid homeostasis that promotes cell death in yeast cells
Authors: Davis Jack , Meyer Thorsten , Smethurst Daniel , Neuhaus Lisa , Heyden Jonas , Broeskamp Filomena , Edrich Elizabeth , Knittelfelder Oskar , Smolnig Martin , Kolb Dagmar , Haar Tobias von der , Gourlay Campbell , Rockenfeller Patrick
Published: December 2022

The dynamic nature of the actin cytoskeleton controls many cellular processes and a loss of its plasticity has been linked to accelerated cell ageing. Cofilin is an actin-binding protein that controls actin dynamics and is linked to mitochondrial signalling pathways that control drug resistance and cell death. Here we show that cofilin driven stabilisation of actin dynamics leads to a loss in cell wall integrity, vacuole fragmentation and disruption of lipid homeostasis, lipid droplet accumulation and the promotion of necrosis. Our data suggest that these phenotypes are triggered by the inappropriate activation of Protein Kinase C (PKC) which leads to constitutive MAPK signalling. Cofilin-driven activation of the MAPK Slt2 requires the presence of the voltage dependent anion channel (VDAC), which resides in the mitochondrial outer membrane, referred to as Porin 1 (Por1) in yeast. This provides further evidence for a link between actin regulation and mitochondrial signalling. Porin has recently been implicated in lipid transport and we find that prevention of excessive lipid droplet accumulation, achieved by deleting the LRO1 and DGA1 genes, was sufficient to prevent Slt2 activation and restore cellular homeostasis in actin stabilised cells. These data suggest that the integrity of the actin cytoskeleton is essential to maintain the fidelity of MAPK signalling and that this in turn is crucial for the maintenance of lipid homeostasis and cell health in S. cerevisiae. Our data also suggest that chronic actin stabilisation leads to mitochondrial VDAC-dependent Slt2 activation and altered, pro-death, cell fate in yeast cells.
Evaluation of Red-Complex Bacteria Loads in Complete Denture Patients
Authors: Veseli Enis , Staka Gloria , Tovani-Palone Marcos Roberto
Published: December 2022

Objective
To evaluate red-complex bacteria (RCB) loads in edentulous patients, before and after dentures’ insertion.
Materials and Methods
Thirty patients were included in the study. Deoxyribonucleic acid (DNA) isolated from bacterial samples were obtained from the dorsum of the tongue before and 3 months after complete dentures (CDs) insertion in order to identify the presence of RCB (Tannerella forsythia, Porphyromonas gingivalis, and Treponema denticola) and quantify their loads, using real-time polymerase chain reaction (RT-PCR). Bacterial loads were represented as “Lg (genome equivalents/sample)” and the data classified according to the “ParodontoScreen” test.
Results
Significant changes in bacterial loads were observed before and 3 months after the CDs insertion for Porphyromonas gingivalis (0.40 ±0.90 vs 1.29 ±1.64, p = 0.0007), Tannerella forsythia (0.36 ±0.94 vs 0.87 ±1.45, p = 0.005), and Treponema denticola (0.11 ±0.41 vs 0.33 ±0.75, p = 0.03). Before the CDs insertion, all patients had a normal bacterial prevalence range (100%) for all analyzed bacteria. Three months after the insertion, 2 (6.7%) of them had a moderate bacterial prevalence range for Porphyromonas gingivalis, while 28 (93.3%) had a normal bacterial prevalence range.
Conclusion
The use of CDs has a significant impact on increasing RCB loads in edentulous patients.
Do Dysfunctional Attitudes Mediate or Moderate the Association Between Everyday Discrimination and Symptoms of Depression in Adolescents?
Authors: Pancost Sherry , Pössel Patrick
Published: December 2022

We aimed to integrate perceived everyday discrimination into Beck’s cognitive model of depression. Participants included 339 adolescents (M = 14.19, 38.9% female), their majority identified as Black or White. Adolescents completed self-report instruments measuring perceived everyday discrimination, dysfunctional attitudes, and depressive symptoms. Our findings indicated a significant interaction effect between perceived everyday discrimination and dysfunctional attitudes on depressive symptoms. The analysis indicated no mediation effect of dysfunctional attitudes as the indirect effect was nonsignificant. If replicated, our findings highlight the importance of clinicians promoting social change to reduce discrimination and them supporting their clients by validating the unfairness of discrimination, help them to mitigate the negative effects of discrimination, and prepare them to cope with the potential of future discrimination.
Analysis and Validation of Antineutrophil cytoplasmic antibody-associated vasculitis with renal injury of the ferroptosis-related gene CD44 and Pan-Cancer
Authors: Tao Mi , Zeng Ziyue , He Yiqing , Li Yuyan , Liao Wenwen , Nie Haihang , Gao Ping
Published: December 2022

Objective: To investigate the role of ferroptosis in Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal injury.
Methods: GSE104954 and GSE108112 were retrieved from the GEO database and concatenated into one dataset. Expression of ferroptosis-related genes (FRGs) was extracted for differential analysis. The ferroptosis signature genes were identified by LASSO regression and SVM-RFE, and their differential expression levels and diagnostic efficacy were verified by independent data sets. The ceRNA (miRNA-TF-mRNA) regulatory network and clinical diagnostic model were constructed respectively. By using consensus clustering, ferroptosis subtypes were identified. ssGSEA and GSVA were employed to assess immune response and pathway activation. Pan-cancer genes were found in TCGA and GTEx. Differential expression of CD44 in was validated by qPCR and immunohistochemistry from HPA database.
Results:Twenty-four FRGs were differentially expressed in patients with AAV kidney injury. Furthermore, five ferroptosis signature genes were identified by two machine learning algorithms. Not only were differentially expressed in independent datasets, the clinical diagnostic model constructed by these genes provided reference for clinical decision-making, but also the ceRNA network revealed their complex regulatory mechanisms. Unsupervised clustering analysis discovered two ferroptosis subtypes with distinct gene expression, immunological microenvironment, and biological functioning pathways. Notably, CD44 was found to be closely associated with many immune cells, most immune responses, and HLA genes, as well as prognosis, immune cell infiltration, TMB, and MSI in patients with a variety of tumors, suggesting it may be a potential intervention target for human diseases including AAV renal injury and tumors.
Conclusions:Ferroptosis in AAV with renal injury is significantly correlated with the immunological microenvironment. For AAV with renal injury and tumors, CD44 could be a useful intervention target.
“Intravitreal fluocinolone acetonide implant: a prospective, pilot study on patients with chronic diabetic macular edema”
Authors: Nicolò Massimo , Desideri Lorenzo Ferro , Rosa Raffaella , Vagge Aldo , Musetti Donatella , Critelli Alice , Corazza Paolo , Traverso Carlo Enrico
Published: December 2022

OBJECTIVES: To analyze the clinical efficacy and safety profile of intravitreal 0.19 mg fluocinolone acetonide (FAc) implant (Iluvien®) in patients with chronic/ refractory diabetic macular edema (DME)
SUBJECTS/METHODS: This a prospective, cross-sectional pilot study enrolling patients with chronic DME, previously treated with intravitreal anti-vascular endothelial growth factors (VEGF) agents and/or intravitreal corticosteroids. The primary endpoints were the modifications in best-corrected visual acuity (BCVA) and central macular thickness (CMT) during the follow-up. Secondary endpoints were recurrence rate, the presence of systemic and/or ocular adverse events (AEs), including changes in intraocular pressure (IOP).
RESULTS: Fourteen eyes of 11 patients were enrolled in this study. Average follow-up period was 18.7 months ± 8.2. Baseline BCVA improved from 59.6 letters to 61.1 letters after 1 month (p=0.994), 63.1 letters after 3 months (p=0.819), 63.7 letters after 6 months (p=0.635), 68.7 letters after 12 months (p=0.07) and 67.7 letters after 18 months (p=0.505). Baseline CMT significantly decreased from 378 µm before Fac treatment to 336 µm after 1 month (p= 0.034), 320 µm after 3 months (p= 0.015), 329 µm after 6 months (p= 0.05), 314 µm after 12 months (p= 0.0025) and 271 µm after 18 months (p= 0.001). Eight eyes (57.1%) needed to be re-injected with anti-VEGF drugs within 12 months and only one (7.1%) was retreated with DEX implant.
No systemic and/ocular AES were reported, including significant variations in IOP.
CONCLUSIONS: FAc implant can be considered an effective and safe treatment option in patients with chronic/refractory DME.
Cluster Analysis Applied to the Spatiotemporal and Climatological Variability of Precipitation over China
Authors: Fernandes Ronabson Cardoso , Porangaba Gislene Figueiredo Ortiz
Published: December 2022

Rainfall is one of the important climate variables, as it directly affects agriculture, livestock, electricity generation, supplies. And, with the objective of performing a cluster analysis, define homogeneous regions of precipitation for China. For this, the TRMM time series from 1998 to 2017, monthly frequency, was used. With this, a space-time cluster analysis was carried out for China. For verification and validation of these clusters, a linear regression of the homogeneous regions was elaborated with the help of multiple linear regression and its level of significance. The results showed that 8 clusters were needed, ranging from 7.2% (cluster 5) to 18.4% (cluster 3) of China's territory. Although 70.96% of the China region obtained R² greater than 0.99, and 94.88% of its area with R² greater than 0.9, with a valid significance level for this region. Therefore, this work shows an application of cluster analysis with the aid of TRMM data, corroborating to improve the climate understanding of the region.
Retinal microvasculature changes in optical coherence tomography – angiography after severe blunt ocular trauma
Authors: Rocher Antonin , Chirpaz Nicolas , Esminezhad Cedric , Bouvarel Hugo , Burillon Carole , Rochepeau Cédric
Published: December 2022

Background: The pathophysiological origin of the retinal damage present in ocular contusion is not clearly established. It is not known whether it is initially neurodegeneration or vascular ischaemia that leads to retinal atrophy.
Methods: The aim of this study was to evaluate the retinal microvasculature with optical coherence tomography (OCT) - angiography of the eyes affected by severe ocular contusion as compared to the contralateral non-traumatised eyes. The retinal vessel density of superficial (SVP) and deep vascular plexus (DVP), area of choriocapillaris flow voids and foveal avascular zone area were evaluated. The macular thickness in OCT in the acute and late stages of the trauma was also analysed.
Results: A total of 48 patients were included and at both 72 hours and 55 days after severe ocular contusion, there were no significant differences between traumatised and non-traumatised eyes for the vascular density of the SVP, the DVP, the choriocapillaris and area of the foveal avascular zone. But we observed significant increase in macular thickness in traumatised eyes compared to non-traumatised eyes at the initial emergency visit and a decrease in traumatised eyes at follow-up examination.
Conclusions: These results suggest that the micro-vascularisation of the retina and the choriocapillaris are not initially affected in severe ocular contusions. The damage to the retina after trauma is therefore probably neurodegenerative rather than vascular.
Case Report: Biventricular hypertrophic obstructive cardiomyopathy in Patient with Noonan syndrome
Authors: Alfraidy Khaled , Eldeib Moustafa , Amin Mohamed , Nagib Ayman
Published: December 2022

Background: Noonan Syndrome (NS) is characterized by short stature, typical facial dysmorphology, and congenital heart defects. The incidence of NS is estimated to be between 1:1000 and 1:2500 live births. The syndrome is transmitted as an autosomal dominant trait. In approximately 50% of cases, the disease is caused by missense mutations in the PTPN11 gene on chromosome 12, resulting in a gain of function of the non-receptor protein tyrosine phosphatase SHP-2 protein
Case summary: We reported 17-year-old male patient known case of Noonan syndrome with a mutation in PTPN11 gene with HOCM, started to follow up at pediatric cardiology due to murmur, diagnosed as non-obstructive HCM 13 years ago, A year ago he started to follow up at adult cardiology and found to have biventricular obstructive cardiomyopathy.
Oral Administration Sericin-Curcumin Nanoconjugates Inhibits Inflammation and Epithelial-Mesenchymal Transition to Treat Renal Interstitial Fibrosis
Authors: Hu Yang , Zhu Tangsong , gao Shaohui , Duan Aiping , Qin Weisong , Liu Zhihong , Hua Ruinian , Zhang Qiuhong , Bao Hao
Published: December 2022

Background: Chronic kidney disease (CKD) is the most common renal disease. Renal interstitial fibrosis (RIF) is an important marker of the progression of chronic kidney disease. Epithelial-interstitial transformation (EMT) and the release of inflammatory factors are the core mechanisms underlying RIF.
Results: A type of orally administered nanoconjugate composed of curcumin and sericin was successfully synthesized. Following unilateral ureteral obstruction (UUO) in mice, oral gavage of nanoconjugates could significantly downregulate cytokines and proteins that participate in fibrosis in vivo.
Conclusion: In general, sericin-curcumin nanoconjugate dosing via oral administration is an easy and effective therapeutic strategy for suppressing or even reversing the progression of renal interstitial fibrosis.
Willingness to use long-acting injectable PrEP among HIV- negative/unknown men who have sex with men in China: a national multicenter online survey
Authors: Fu Jiaqi , Wang Hao , Si Mingyu , Dai Zhenwei , Chen Xu , Wu Yijin , Xiao Weijun , Huang Yiman , Yu Fei , Mi Guodong , Su Xiaoyou
Published: December 2022

Background:Men who have sex with men (MSM) are at high risk of HIV acquisition. Long-acting injectable- (LAI-) PrEP, requiring less frequent dosing, is being studied as an alternative method to daily oral HIV PrEP. With the addition of this potential new prevention method, it expands the scope for a wider user choice and is expected to increase the acceptability and uptake of HIV prevention measures.Methods:Participants were recruited from December 2020 to March 2021through banner advertisements on web- and mobile app-based platforms on Blued, a large gay Chinese social media platform. A total of 969 HIV-negative/unknown participants were included in our study. Multivariate logistic regression was used to analyze the factors associated with the willingness to use LAI-PrEP.Results:In total, 969 participants met the inclusion criteria and finished the survey. 19.5% of participants had never tested for HIV, 66.8% of MSM had multiple male partners, and 51.6% of MSM engaged in the condomless sex with their partner. 66.3% of MSM were aware of PrEP, and only 3.9% of MSM had used PrEP before. The willingness to use daily oral PrEP and LAI-PrEP was 76.6% and 74.0%, respectively. MSM with higher education level were less likely to show willingness to use LAI-PrEP (AOR=0.561, 95%CI: 0.375-0.838). Participants who had the history of HIV test (AOR=1.684, 95%CI: 1.109-2.556), had the willingness to use daily oral PrEP (AOR=10.635,95%CI:7.434-15.214), had multiple male sexual partners (AOR=1.332, 95%CI:0.933-1.903), who used rush popper(AOR=1.494, 95%CI:1.047-2.131), and who were aware of PEP (AOR=1.659, 95%CI: 1.019-2.702) were more likely to show willingness to use LAI-PrEP.Conclusions:In our study, the study subjects had moderate awareness and low uptake of PrEP. The willingness to use daily oral PrEP and LAI-PrEP among the participants were both high. Education level, history of HIV test, multiple male sexual partnerships, rush popper use, PrEP awareness and willingness to use daily oral PrEP were factors associated with the willingness to use LAI-PrEP. This study provided some evidence for the further scale-up of PrEP among the MSM population.
Hemodynamics of thrombus formation in intracranial aneurysms: an in-silico observational study
Authors: Liu Qiongyao , Sarrami-Foroushani Ali , Wang Yongxing , MacRaild Michael , Kelly Christopher , Lin Fengming , Xia Yan , Song Shuang , Ravikumar Nishant , Patankar Tufail , Taylor Zeike A. , Lassila Toni , Frangi Alejandro F.
Published: December 2022

How prevalent is spontaneous thrombosis (ST) in intracranial aneurysms (IAs) for an all-size pop- ulation? How can we calibrate computational models of thrombosis based on published data from size-specific aneurysms cohorts? How does ST differ in normo- and hypertensive subjects? We ad- dress the first question by a thorough analysis of published that provide ST rates across different patient demographics and aneurysm characteristics. This analysis provides data for a subgroup of the gen- eral population, viz. large and giant aneurysms (>10 mm). Based on these observed ST rates, our novel computational modelling platform enables the first in-silico observational study of ST prevalence across a broader set of IA phenotypes. We generate 109 virtual patients and use a novel approach to calibrate two trigger thresholds: residence time (RT) and shear rate (SR), thus addressing the second question. We then address the third question by utilising this calibrated thrombosis model to provide new insights on the effects of hypertension on ST.
We demonstrate how a mechanistic ST model calibrated on a reduced IA cohort can help esti- mate ST prevalence in a broader IA population. This study was enabled through a comprehensive and fully automatic multi-scale modeling pipeline. We use an emerging property, viz. ST, as an indirect population-level validation of a complex computational modeling framework. Furthermore, our frame- work allows exploration of the influence of hypertension in ST. This lays the foundation for in-silico clinical trials of cerebrovascular devices in high-risk populations, e.g. assessing the performance of flow diverters in cerebral aneurysms for hypertensive patients.
Musculoskeletal Manifestations, Post-COVID Syndrome, Relationship with Laboratory Parameters in Hospitalized Patients Infected with COVID-19
Authors: Kuculmez Ozlem , Genctoy Gültekin , Arıkan Serap
Published: December 2022

Background:
This study aims to characterize the prevalence of musculoskeletal manifestations in hospitalized COVID-19 patients and the relationship between C-Reactive protein (CRP) and interleukin levels.
Methods:
A medical records review study was performed on patients at Baskent University between March 7 and December 31, 2020. The study included hospitalized patients above 18 years diagnosed with COVID-19 by polymerase chain reaction. Pregnant individuals, those with end-stage disease or missing documentation were excluded. Patient demographics and laboratory results were obtained from electronic health records and previous study performed in the same hospital. The relationship between musculoskeletal manifestations, CRP, and interleukin levels were determined. A Pvalue of less than .05 was consideredstatistically significant.
Results:
Totally, 109 patients were analyzed; 34.86% (n = 38) of the patients had arthralgia, 1.83% (n = 2) had arthritis, 41.28% (n = 45) underwentfatigue, and 32.11% (n = 35) experiencedpost-COVID syndrome. There was no correlation between musculoskeletal manifestations, CRP, and interleukin levels (P > .05). There was positive correlation between post-COVID syndrome, fatigue, duration of O2 support, duration of hospitalization (P < .05), and the patients were elderly. CRP levels were positively correlated with duration of hospitalization, duration of O2 support, history of intensive care, and duration of intensive care (P < .05). Interleukin 6 levels were positively correlated with CRP levels, duration of hospitalization, and O2 support duration (P < .05), but there was no correlation with interleukin 10 levels (P > .05).
Conclusion:
There was no correlation between musculoskeletal manifestations, CRP, and interleukin levels. Patients who are hospitalized, elderly, abnormally fatigued, or O2 supported should be followed for post-COVID syndrome.
SARS-CoV-2: gone with the evolution
Authors: Romeu Antonio R.
Published: December 2022

Starting at the end, evolution is erasing the imprinted CGG-CGG genetic footrprint on theSARS-CoV-2 acquired with the furin cleavage site. CGG-CGG is the original code ofthe arginine pair inthe polybasic furin cleavage site of the viralS protein. CGG-CGGis the heart of the 12nucleotide length sequence that properly inserted into the S gene encoded the PRRA motif in the early viruses. In Omicron it isHRRA. In terms of functionality, this arginine dimer in the SARS-CoV-2 S proteinis untouchable, but its code is very unfavourable for the virus. So it is plausiblethat asolution for the virus should go through an argininebias codon usage in the furin site. The aimof this study was to going onwith the longitudinal study on the evolution of this furin site arginine dimer, so essential for the virus. However, the surprise has been to discover that at least in the CQ.2 lineage, based on theavailable GISAID genomes, the original CGG-CGG arginine code has been lost and optimized in the 99.65 % of cases. It is worth noting thatthe new codon usage matches the arginine pair of the SARS-CoV-2 furin clevage site and arginine pairsof other viral proteins (e.g., nsp13, nucleocapsid) of both SARS-CoV-2and bat coronaviruses.
Practices of water, sanitation, and hygiene and its association with diarrheal infection among under-5 children in Chattogram, Bangladesh
Authors: Sujon Minhajul Abedin , Hossain Syed Billal , Chowdhury ABM Alauddin , BakiBillah Abul Hasan , Akter Nasima
Published: December 2022

This study aims to address the association between the practices of water, sanitation & hygiene, and diarrheal infection among Under-5 Children in Chattogram, Bangladesh. This cross-sectional survey study was conducted among 182 mothers of children under five years of age living in Chattogram City, Bangladesh. The probability proportional sampling (PPS) technique was applied to interview the study participants. The study found that 37.4% of participants had toilets with ideal sanitary facilities. Mothers' estimates of toilet cleanliness demonstrated a Pearson association with their child's diarrheal count in the previous 12 months (P = 0.007), whereas variations in toilet usage (P = 0.024), toilet cleaning frequency each week (P = 0.014) and availability of sewage channel with toilet (P = 0.012) evidence significant association with diarrheal infection frequency in the last 12 months. Washing hands after using the toilet (P = 0.002), washing fruits/vegetables before eating or cooking (P < 0.000), washing hands before and after food consumption (P < 0.012) & types of soap uses to wash hands (P = 0.017) were found significantly associated with diarrheal infection. 41.8% participants were found, who use no filtration method to purify their drinking water, however, the study found no significant association between water consumption practices with diarrheal infection frequency among respondents’ children under five years of age.
Adaptive control of the overhead crane by the trolley speed
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Kruglov S. P. , Aksamentov D. N. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: December 2022

A method is proposed for automatic control of the speed of an overhead-type crane trolley with direct tracking of the horizontal movement of load in conditions of current uncertainty of load parameters and external disturbances. The purpose of the control is to find the precise positioning of the transported cargo with the damping of its pendulum oscillations and the parrying of external disturbances. The dynamics of an overhead crane when moving a trolley along one axis is described. The proposed control method is based on an adaptive control scheme with an identifier and an implicit reference model using «simplified» adaptability conditions. The stability of a closed control system is proved and the conditions for this are determined. For the current identification of load parameters, the recursive least squares method with a forgetting factor is used. This control method was developed specifically for research and debugging on an experimental layout, so all the parameters of the crane and load were approximated to the layout during calculations. The results of computer simulation the proposed control method with different mass-inertial properties of the load, the length of its suspension and perturbations in the Matlab Simulink software environment are presented. The results showed the high efficiency of the proposed adaptive control system. It ensures accurate movement of the load in a short period of time, prevents the load from swinging during acceleration and braking of the cart, and is also able to fend off external disturbances, for example, the impact of wind. The developed approach can be recommended for any crane installations using a suspended load.
Manufacture of InP-based electro-optical modulators for FOCL and automated visual inspection of their surface for defects
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Shurygin Yu. A. , Ishutkin S. V. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Shiryaev B. V. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Zhidik Y. S. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: December 2022

Electro-optical modulators are key elements in the construction of fiber-optic communication lines. In this work, the authors developed a technology for manufacturing Mach-Zender electro-optical modulators based on InP. The developed technology was tested while manufacturing test samples of electro-optical modulators. The defects on the surface of the samples were visually inspected in an automated mode using the algorithm developed by the authors.
Intelligent System Architecture for Identification of the Source Code Author
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Kurtukova A. V. , Romanov A. S. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Fedotova A. M. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Shelupanov A. A. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: December 2022

The development of solutions for identifying the source code author is relevant for the field of intellectual property and copyright protection. Such solutions are important for the analysis of the industrial software product source codes, which are developed on the basis of a large number of professional studies. This paper presents the architecture of the intelligent system for identifying the source code author based on a deep hybrid neural network. The paper also describes the main structural elements of the system being developed and their interfaces, as well as the mechanisms necessary for its correct and high performance.