bluuebunny/crossref_metadata_2025 huggingface dataset:
CT is a feasible imaging technique for detecting lesions in horses with elbow lameness: A study of 139 elbows in 99 horses
Authors: Zimmerman Marieke , Schramme Michael , Barthélemy Anthony , Mariën Tom , Thomas‐Cancian Aurélie , Ségard‐Weisse Emilie
Published: January 2022

Computed tomography (CT)is increasingly available in veterinary referral practices; however, published studies describing CT lesions of the equine elbow are currently lacking. In this single‐center, retrospective, observational study, horses undergoing elbow CT at Equitom between July 2015 and October 2018 were reviewed. Subchondral bone sclerosis; resorption of the radius, ulna, and humerus; osteophyte; and enthesophyte lesions were graded. One hundred thirty‐nine elbows of 99 horses (16 with elbow pain and 123 control elbows) were included (median age, 9 years). Osseous cyst‐like lesions (n = 13), only seen in the proximomedial radius and medial humerus, were the most common cause of lameness in horses with elbow pain (n = 16), with significantly higher grades of bone resorption (including osseous cyst‐like lesions) in this group. One elbow had an avulsion fracture of the lateral epicondyle, two others showed signs of osteoarthritis. Significantly higher grades of sclerosis in the proximomedial radius were seen in horses with elbow pain; however, mild to moderate subchondral bone sclerosis was seen in all horses at the medial aspect of the joint. Osteochondral fragmentation lesions of the weight‐bearing surface of the medial radius (2/16 vs 1/123;P = .0025) and intra‐articular gas (4/16 vs 2/123;P < .0001) were significantly more common in horses with elbow pain compared to control horses. Mild linear resorptive subchondral bone lesions were often not clinically relevant (32/123 vs 5/16 in medial humerus; 19/123 vs 2/16 in medial radius). In conclusion, elbow CT is a feasible method for detecting clinically relevant lesions in adult Warmblood horses with elbow pain.
REVISITING WILLIAM PALEY
Authors: Brooke John Hedley
Published: January 2022

Evaluations of William Paley'sNatural Theology(1802) routinely refer to its philosophical and theological shortcomings, especially its vulnerability to Charles Darwin's scientific naturalism. Nevertheless, Paley still repays a visit as a subject who transcends common stereotypes, four of which invite correction: that Paley wrote in culpable neglect of David Hume; that he pretended to give a deductive demonstration of God's existence; that by making hisNatural Theologya stand‐alone book, his apologetic framework was neglectful of revelation and therefore inconsequential for Christian theology; and that, preoccupied with the minutiae of anatomical specificity, he was blind to laws connecting natural phenomena. Nuances in Paley's thinking, particularly his allowance for the extension of scientific naturalism, help to explain the sympathetic recognition he still enjoyed among scientific figures until the end of the nineteenth century. For Thomas Huxley, he had even created a metaphysical space that allowed for a science of evolution.
Investigation of Facilities Management Implementation Process for Malaysian State Mosque
Authors: Ab. Muin Zafirah , Sapri Maimunah , Sipan Ibrahim , Abdullah Hashim Hariati
Published: January 2022

The mosque has been a focal point of Islam since its inception, serving as a place of worship, a centre of education, economic pursuits, communal services, and spirituality. However, due to a variety of causes, the scope of mosque functions has been constrained as the world has developed rapidly. In summary, congregational capacity and facilities relating to hygiene, safety, and space utilisation are among the problems being closely examined in Malaysia. Based on the problems, the subject of mosque management's competencies that need to be improved in order to become more professional arises. Reviews of literature suggested that facilities management (FM) approach has the potential to be incorporated in the management of mosque. The purpose of this study is to examine the implementation of FM process in mosque in supporting the achievement of mosque’s functions. A quantitative approach was adopted in this study. The implementation of FM process from 12 state mosques in Peninsular Malaysia were investigated using questionnaire survey which distributed among the mosque management that manage mosque facilities. Descriptive statistics were used to analyse the questionnaire survey data with Statistical Package for the Social Sciences (SPSS) software. Results from the questionnaire survey revealed that, 50 per cent of the mosque has implemented most of the FM process model elements whereas other mosque still need further improvement to ensure the standards of FM process model is achieved. The results indicated that there is potential for improvement in mosque that possesses low position in implementing elements of FM process model that includes FM formulation strategy, requirement analysis of services, FM solutions development, FM solutions implementation and monitoring service provision. The finding could assist the top management level of the mosque in strategising the implementation action plan of mosque facilities management.
Mechanical Deformation of Peripapillary Retina in Response to Acute Intraocular Pressure Elevation
Authors: Kwok Sunny , Pan Manqi , Hazen Nicholas , Pan Xueliang , Liu Jun
Published: January 2022

Elevated intraocular pressure (IOP) may cause mechanical injuries to the optic nerve head (ONH) and the peripapillary tissues in glaucoma. Previous studies have reported the mechanical deformation of the ONH and the peripapillary sclera (PPS) at elevated IOP. The deformation of the peripapillary retina (PPR) has not been well-characterized. Here we applied high-frequency ultrasound elastography to map and quantify PPR deformation, and compared PPR, PPS and ONH deformation in the same eye. Whole globe inflation was performed in ten human donor eyes. High-frequency ultrasound scans of the posterior eye were acquired while IOP was raised from 5 to 30 mmHg. A correlation-based ultrasound speckle tracking algorithm was used to compute pressure-induced displacements within the scanned tissue cross sections. Radial, tangential, and shear strains were calculated for the PPR, PPS, and ONH regions. In PPR, shear was significantly larger in magnitude than radial and tangential strains. Strain maps showed localized high shear and high tangential strains in PPR. In comparison to PPS and ONH, PPR had greater shear and a similar level of tangential strain. Surprisingly, PPR radial compression was minimal and significantly smaller than that in PPS. These results provide new insights into PPR deformation in response of IOP elevation, suggesting that shear rather than compression was likely the primary mode of IOP-induced mechanical insult in PPR. High shear, especially localized high shear, may contribute to the mechanical damage of this tissue in glaucoma.
Transient Operation of Sensible Fixed-Bed Regenerators
Authors: Ramin Hadi , Krishnan Easwaran N. , Gurubalan Annadurai , Simonson Carey J.
Published: January 2022

Fixed-bed regenerator is a type of air-to-air energy exchanger and recently introduced for energy recovery application in heating, ventilation, and air conditioning (HVAC) systems because of their high heat transfer effectiveness. The testing of fixed-bed regenerators (FBRs) is essential for performance evaluation and product development. American Society of Heating Refrigeration and Air Conditioning Engineers (ASHRAE) and Canadian Standards Association (CSA) recently included guidelines for testing of FBRs in their respective test standards. The experiments on FBRs are challenging as they never attain a steady-state condition, rather undergoes a quasi-steady-state operation. Before reaching the quasi-steady state, FBRs undergo several transient cycles. Hence, the test standards recommend getting measurements after one hour of operation, assuming FBR attains the quasi-steady state regardless of test conditions. However, the exact duration of the initial transient cycles is unknown and not yet studied so far. Hence, in this paper, the duration of FBR’s transient operation is investigated for a wide range of design and operating conditions. The test standards’ recommendation for the transient duration is also verified. The major contributions of this paper are (i) quantifying the effect of design parameters (NTUo and Cr*) on the duration of transient operation and (ii) the investigation of the effect of sensor time constant on the transient temperature measurements. The results will be useful to predict and understand the transient behavior of FBRs accurately.
Experimental and Numerical Study of the Turbulent Flow and Heat Transfer in a Wedge-Shaped Channel With Guiding Pin Fin Arrays Under Rotating Conditions
Authors: Liang Ce , Rao Yu , Chen Jianian , Zhang Peng
Published: January 2022

Experiments and numerical simulations under stationary and rotating conditions have been conducted to investigate turbulent flow and heat transfer characteristics of innovative guiding pin fin arrays in a wedge-shaped channel, which models the internal cooling passages for modern gas turbine blade trailing edge. The Reynolds number range is 10,000–80,000, and the inlet rotation number range is 0–0.46. With the increase of Reynolds number, the enhancement of heat transfer performance of the channel with guiding pin fin arrays is significantly higher than that of the channel with conventional circular pin fin arrays. At the highest Reynolds number of Re = 80,000, the overall Nusselt number of the channel with guiding pin fin arrays is about 33.7% higher than that of the channel with circular pin fin arrays under the stationary condition and is about 23.0% higher than the latter under the rotating conditions. At the highest inlet rotation number of Ro = 0.46, the heat transfer difference between the trailing side and leading side of the channel is significantly lower with the guiding pin fin arrays than with the circular pin fin arrays. Through both the experiments and numerical simulations, it is found that the heat transfer uniformity of the endwall is significantly improved by the guiding pin fin arrays, and the rotation presents appreciably less influence on the heat transfer distribution with the guiding pin fin arrays than with the circular pin fin arrays. Moreover, the novel guiding pin fins provide more reasonable flow distribution in the wedge-shaped channel and produce obviously higher heat transfer performance in the tip region of the channel, which is significantly advantageous for a better design of gas turbine blade trailing edge internal cooling.
Heat Transfer in Rotating, Trailing Edge, Converging Channels With Full- and Partial-Height Strip-Fins
Authors: Sahin Izzet , Chen I-Lun , Wright Lesley M. , Han Je-Chin , Xu Hongzhou , Fox Michael
Published: January 2022

A wide variety of pin-fins have been used to enhance heat transfer in internal cooling channels. However, due to their large blockage in the flow direction, they result in an undesirable high pressure drop. This experimental study aims to reduce pressure drop while increasing the heat transfer surface area by utilizing strip-fins in converging internal cooling channels. The channel is designed with a trapezoidal cross section, converges in both transverse and longitudinal directions, and is also skewed β=120deg with respect to the direction of rotation to model a trailing edge cooling channel. Only the leading and trailing surfaces of the channel are instrumented, and each surface is divided into 18 isolated copper plates to measure the regionally averaged heat transfer coefficient. Utilizing pressure taps at the inlet and outlet of the channel, the pressure drop is obtained. Three staggered arrays of strip-fins are investigated: one full-height configuration and two partial fin height arrangements (Sz = 2 mm and 1 mm). In all cases, the strip-fins are 2 mm wide (W) and 10 mm long (Lf) in the flow direction. The fins are spaced such that Sy/Lf = 1 in the streamwise direction. However, due to the convergence, the spanwise spacing, Sx/W, was varied from 8 to 6.2 along the channel. The rotation number of the channel varied up to 0.21 by ranging the inlet Reynolds number from 10,000 to 40,000 and rotation speed from 0 to 300 rpm. It is found that the full-height strip-fin channel results in a more nonuniform spanwise heat transfer distribution than the partial-height strip-fin channel. Both trailing and leading surface heat transfer coefficients are enhanced under rotation conditions. The 2 mm height partial strip-fin channel provided the best thermal performance, and it is comparable to the performance of the converging channels with partial-length circular pins. The strip-fin channel can be a design option when the pressure drop penalty is a major concern.
Pulsed chemical vapor deposition of cobalt and cobalt carbide thin films
Authors: Chen Sen , Zhang Xiangyu , Liu Bowen , Liu Zhongwei
Published: January 2022

Cobalt and cobalt carbide films were successfully fabricated via a simple pulsed chemical vapor deposition (PCVD) technique. The PCVD process employs bis(1,4-di-tert-butyl-1,3-diazadienyl) cobalt as a cobalt precursor. The effect of the reducing agent, H2 gas or H2 plasma, on the chemical composition of the resulting films has been carefully investigated. In the presence of H2 gas, polycrystalline hexagonal close-packed Co was obtained through the thermal decomposition of the Co precursor. When H2 plasma was used as a coreactant, the cobalt carbide was successfully deposited instead. The crystal structure of the deposited film is orthorhombic Co2C. X-ray photoelectron spectroscopy and Raman spectroscopy results show that all the carbon contained in the films were in form of Co–C. The dependence of deposition temperature on cobalt and cobalt carbide characteristics has also been investigated.
The Effect of Active Release Technique® on Clinician and Patient-Reported Outcomes: A Systematic Review
Authors: Barnes Precious , Rivera Matthew
Published: January 2022

Context: Active Release Technique® (ART®) is a manual therapy used for soft tissue-related issues, commonly used to lengthen structures in a shortened position and to restore motion of soft tissues. Objective: The purpose of this systematic review was to collect, appraise, and summarize the available literature, evaluating the effects of ART® on pain, range of motion (ROM), and disability. Evidence Acquisition: Electronic databases (PubMed, EBSCOhost, MEDLINE, SPORTDiscus, and CINAHL) were searched from 2000 to November 2020. The search was completed using a combination of key words related to ART®, rehabilitation, and outcomes. Search limits were full-text publications written in English. Inclusion criteria required that studies evaluated outcomes using ART® for rehabilitation, were peer reviewed, and included human participants without catastrophic conditions or injuries. The modified Downs and Black checklist for nonrandomized studies was used to assess methodological quality of identified studies by 2 independent reviewers, average scores were calculated. The level of evidence was assessed using the strength of recommendation taxonomy. Evidence Synthesis: Nine studies were inculded in this review. The average methodological quality of the studies was 12/15 and ranged from 10 to 14, with the most common methodological quality item missed being the blinding of researchers collecting outcomes. Six studies that assessed pain found significant improvements in participants’ pain levels. Six studies that assessed ROM found significant improvement in participants’ ROM. Two studies that assessed disability found significant improvement in disability. Conclusion: Evidence suggests that ART® may be beneficial in improving pain, ROM, and disability. This review found that ART® positively impacted patient outcomes and may be a viable treatment option for clinicians treating musculoskeletal conditions. However, further research is necessary to determine optimal dosage and long-term effects of ART® on these patient outcomes.
Acute Response to One Bout of Dynamic Standing Exercise on Blood Glucose and Blood Lactate Among Children and Adolescents With Cerebral Palsy Who are Nonambulant
Authors: Lundström Petra , Lauruschkus Katarina , Andersson Åsa , Tornberg Åsa B.
Published: January 2022

Purpose: To investigate the acute exercise effects of dynamic standing exercise on blood glucose and blood lactate among children and adolescents with cerebral palsy who are nonambulant. Methods: Twenty-four participants with cerebral palsy who are nonambulant performed 30 minutes of dynamic standing exercise using a motorized device enabling assisted passive movements in an upright weight-bearing position. Capillary blood samples were taken from the fingertip for measurement of blood glucose and blood lactate at rest and at the end of exercise. Results: At rest, the participants had hyperlactatemia that was unaffected after exercise, presented as median and interquartile range at rest 1.8 (1.3:2.7) mmol/L, and after exercise 2.0 (1.1:2.5) mmol/L. Children and adolescents with Gross Motor Function Classification System, level V, had higher lactate levels at rest (2.5 [1.8:2.9] vs 1.4 [1.0:2.0]; P = .030) and after exercise (2.3 [2.0:2.6] vs 1.2 [0.9:2.2]; P = .032) compared with children and adolescents with Gross Motor Function Classification System, level IV, respectively. A statistically significant larger decrease in blood lactate levels after exercise was observed in children and adolescents with higher resting blood lactate levels (ρ = .56; P = .004). There were no statistically significant changes in blood glucose. Conclusions: Forty percentage of the participants had mild hyperlactatemia at rest and participants with the highest blood lactate levels at rest had the greatest decrease in blood lactate levels after one bout of exercise. Children and adolescents who were classified with the highest level of the Gross Motor Function Classification Scale had higher blood lactate levels. More studies are needed on how to prevent chronically high resting levels of lactate with exercise in children with cerebral palsy who are nonambulant.
A Humanized Monoclonal Antibody Potentiates Killing of Diverse Biofilm-Forming Respiratory Tract Pathogens by Antibiotics
Authors: Kurbatfinski Nikola , Goodman Steven D. , Bakaletz Lauren O.
Published: January 2022

New strategies to treat diseases in which biofilms contribute significantly to pathogenesis are needed, as biofilm-resident bacteria are highly recalcitrant to antibiotics due to physical biofilm architecture and a canonically quiescent metabolism, among many additional attributes. We, and others, have shown that when biofilms are dispersed or disrupted, bacteria released from biofilm residence are in a distinct physiologic state that, in part, renders these bacteria highly sensitive to killing by specific antibiotics.
In Vitro
Time-Kill Studies of Trimethoprim/Sulfamethoxazole against Stenotrophomonas maltophilia versus Escherichia coli Using Cation-Adjusted Mueller-Hinton Broth and ISO-Sensitest Broth
Authors: Lasko Maxwell J. , Gethers Matthew L. , Tabor-Rennie Jennifer L. , Nicolau David P. , Kuti Joseph L.
Published: January 2022

Trimethoprim/sulfamethoxazole (TMP/SMZ) is considered the treatment of choice for infections caused by
Stenotrophomonas maltophilia
, but limited pharmacodynamic data are available to support current susceptibility breakpoints or guide optimal dosing. Time-kill studies using a TMP/SMZ concentration of 4/40 μg/mL were conducted to compare 4
S. maltophilia
with 4
Escherichia coli
isolates having the same MICs (0.25/4.75 to 4/76 μg/mL) in cation-adjusted Mueller-Hinton broth (CAMHB) and ISO-Sensitest broth (ISO broth).
Climate change impact and adaptation for highway asphalt pavements: a literature review
Authors: Swarna Surya T. , Hossain Kamal
Published: January 2022

For the past few decades, researchers all over the world have agreed that the service life of civil infrastructure is significantly affected by climate change. Pavement is one of these significant infrastructures that can be easily affected by climate change. However, it is well known that predicting climate change is highly complex and dynamic. Hence, a review has been done on available climate change models and the uncertainties involved in climate change prediction. This review addresses various important questions, such as (i) what climate change is, (ii) how to use climate change models, (iii) uncertainties involved in using climate change models, (iv) how climate change impacts pavement infrastructure, (v) the adaptation and mitigation strategies available, and (vi) how economic costs and emissions change due to climate change. This review is useful to understand climate change and its implications on pavement infrastructure.
Advanced breakup-nucleon enhancement of deuteron-induced reaction cross sections
Authors: Avrigeanu M. , Rochman D. , Koning A. J. , Fischer U. , Leichtle D. , Costache C. , Avrigeanu V.
Published: January 2022

Following the EUROfusion PPPT-programme action for an advanced modeling approach of deuteron-induced reaction cross sections, as well as specific data evaluations in addition of the TENDL files, an assessment of the details and corresponding outcome for the latter option of TALYS for the breakup model has been carried out. The breakup enhancement obtained in the meantime within computer code TALYS, by using the evaluated nucleon-induced reaction data of TENDL-2019, is particularly concerned. Discussion of the corresponding results, for deuteron-induced reactions on$$^{58}$$58Ni,$$^{96}$$96Zr, and$$^{231}$$231Pa target nuclei up to 200 MeV incident energy, includes limitations still existing with reference to the direct-reaction account.
Islands and Page curves in charged dilaton black holes
Authors: Yu Ming-Hui , Ge Xian-Hui
Published: January 2022

We study the Page curve for eternal Garfinkle–Horowitz–Strominger dilaton black holes in four dimensional asymptotically flat spacetime by using the island paradigm. The results demonstrate that without the island, the entanglement entropy of Hawking radiation is proportional to time and becomes divergent at late times. While taking account of the existence of the island outside the event horizon, the entanglement entropy stops growing at late times and eventually reaches a saturation value. This value is twice of the Bekenstein–Hawking entropy and consistent with the finiteness of the von Neumann entropy of eternal black holes. Moreover, we discuss the impact of the stringy coefficient n and charge Q on the Page time and the scrambling time respectively. For the non-extremal case, the influence of the coefficient n on them is small compared to the influence of the charge Q. However, for the extremal case, the Page time and the scrambling time become divergent or near vanishing. This implies the island paradigm needs further investigation.
Multi-partonic medium induced cascades in expanding media
Authors: Adhya Souvik Priyam , Salgado Carlos A. , Spousta Martin , Tywoniuk Konrad
Published: January 2022

Going beyond the simplified gluonic cascades, we introduce both gluon and quark degrees of freedom for partonic cascades inside the medium. We then solve the set of coupled evolution equations numerically with splitting kernels calculated for static, exponential, and Bjorken expanding media to arrive at medium-modified parton spectra for quark and gluon initiated jets. Using these, we calculate the inclusive jet $$R_\mathrm {AA}$$

R
AA

where the phenomenologically driven combinations of quark and gluon jet fractions are included. Then, the rapidity dependence of the jet $$R_\mathrm {AA}$$

R
AA

is examined. We also study the path-length dependence of jet quenching for different types of expanding media by calculating the jet $$v_2$$

v
2

. Additionally, we study the sensitivity of observables on effects from nuclear modification of parton distribution functions, vacuum-like emissions in the plasma, and the time of the onset of the quenching. All calculations are compared with recently measured data.
Hadron interactions for arbitrary energies and species, with applications to cosmic rays
Authors: Sjöstrand Torbjörn , Utheim Marius
Published: January 2022

ThePythiaevent generator is used in several contexts to study hadron and lepton interactions, notably$$\mathrm{p}\mathrm{p}$$ppand$$\mathrm{p}{\bar{\mathrm{p}}}$$pp¯collisions. In this article we extend the hadronic modelling to encompass the collision of a wide range of hadronshwith either a proton or a neutron, or with a simplified model of nuclear matter. To this end we model$$h\mathrm{p}$$hptotal and partial cross sections as a function of energy, and introduce new parton distribution functions for a wide range of hadrons, as required for a proper modelling of multiparton interactions. The potential usefulness of the framework is illustrated by a simple study of the evolution of cosmic rays in the atmosphere, and by an even simpler one of shower evolution in a solid detector material. The new code will be made available for future applications.
Hamiltonian formulation of higher rank symmetric gauge theories
Authors: Banerjee Rabin
Published: January 2022

Recent discussions of fractons have evolved around higher rank symmetric gauge theories with emphasis on the role of Gauss constraints. This has prompted the present study where a detailed hamiltonian analysis of such theories is presented. Besides a general treatment, the traceless scalar charge theory is considered in details. A new form for the action is given which, in $$2+1$$

2
+
1

dimensions, yields area preserving diffeomorphisms. Investigation of global symmetries reveals that this diffeomorphism invariance induces a noncommuting charge algebra that gets exactly mapped to the algebra of coordinates in the lowest Landau level problem. Connections of this charge algebra to noncommutative fluid dynamics and magnetohydrodynamics are shown.
On a structure of the one-loop divergences in 4D harmonic superspace sigma-model
Authors: Buchbinder I. L. , Budekhina A. S. , Merzlikin B. S.
Published: January 2022

We study the quantum structure of four-dimensional $${{\mathcal {N}}}=2$$

N
=
2

superfield sigma-model formulated in harmonic superspace in terms of the omega-hypermultiplet superfield $$\omega $$
ω
. The model is described by harmonic superfield sigma-model metric $$g_{ab}(\omega )$$

g

ab

(
ω
)

and two potential-like superfields $$L^{++}_{a}(\omega )$$

L
a

+
+

(
ω
)

and $$L^{(+4)}(\omega )$$

L

(
+
4
)

(
ω
)

. In bosonic component sector this model describes some hyper-Kähler manifold. The manifestly $${{\mathcal {N}}}=2$$

N
=
2

supersymmetric covariant background-quantum splitting is constructed and the superfield proper-time technique is developed to calculate the one-loop effective action. The one-loop divergences of the superfield effective action are found for arbitrary $$g_{ab}(\omega ), L^{++}_{a}(\omega ), L^{(+4)}(\omega )$$

g

ab

(
ω
)

,

L
a

+
+

(
ω
)

,

L

(
+
4
)

(
ω
)

, where some specific analogy between the algebra of covariant derivatives in the sigma-model and the corresponding algebra in the $${{\mathcal {N}}}=2$$

N
=
2

SYM theory is used. The component structure of divergences in the bosonic sector is discussed.
Eigenvalue inequalities for positive block matrices with the inradius of the numerical range
Authors: Bourin Jean-Christophe , Lee Eun-Young
Published: January 2022

We prove the operator norm inequality, for a positive matrix partitioned into four blocks in [Formula: see text], [Formula: see text] where [Formula: see text] is the diameter of the largest possible disc in the numerical range of [Formula: see text]. This shows that the inradius [Formula: see text] satisfies [Formula: see text] Several eigenvalue inequalities are derived. In particular, if [Formula: see text] is a normal matrix whose spectrum lies in a disc of radius [Formula: see text], the third eigenvalue of the full matrix is bounded by the second eigenvalue of the sum of the diagonal block, [Formula: see text] We think that [Formula: see text] is optimal and we propose a conjecture related to a norm inequality of Hayashi.
A novel lattice hydrodynamic model accounting for individual difference of honk effect for two-lane highway under V2X environment
Authors: Li Xiaoqin , Peng Guanghan
Published: January 2022

In this work, the individual difference of the honk effect is explored on two lanes via traffic modeling of the lattice model under Vehicle to X (V2X) environment. We study the impact of individual difference corresponding to honk cases on traffic stability through linear stability analysis for a two-lane highway. Furthermore, the mKdV equation under the lane changing phenomena is conducted via nonlinear analysis. Simulation cases for the early time and longtime impact reveal that individual difference of driving characteristics has a distinct impact on two lanes under the whistling environment.
Web Blog Content Curation Using Fuzzy-Related Capsule Network-Based Auto Encoder
Authors: Khatter Harsh , Ahlawat Anil
Published: January 2022

The internet content increases exponentially day-by-day leading to the pop-up of irrelevant data while searching. Thus, the vast availability of web data requires curation to enhance the results of the search in relevance to searched topics. The proposed F-CapsNet deals with the content curation of web blog data through the novel integration of fuzzy logic with a machine learning algorithm. The input content to be curated is initially pre-processed and seven major features such as sentence position, bigrams, TF-IDF, cosine similarity, sentence length, proper noun score and numeric token are extracted. Then the fuzzy rules are applied to generate the extractive summary. After the extractive curation, the output is passed to the novel capsule network based deep auto-encoder where the abstractive summary is produced. The performance measures such as precision, recall, F1-score, accuracy and specificity are computed and the results are compared with the existing state-of-the-art methods. From the simulations performed, it has been proven that the proposed method for content curation is more efficient than any other method.
Evaluation Algorithm of Skilled Talents’ Quality Based on Deep Belief Network Model
Authors: Hua Jiang , Tao Sun
Published: January 2022

In order to solve the problem that the evaluation algorithm is easy to fall into local extremum, which leads to slow convergence speed, a skilled talent quality evaluation algorithm based on a deep belief network model was designed. Establish an evaluation set with 4 first level indicators and 14 second level indicators, and calculate the corresponding weights to complete the construction of the evaluation index system. A DBN structure composed of several RBMs and a BP network is constructed. Based on the DBN, a quality evaluation algorithm is designed. The algorithm training is used to evaluate the test data and output the evaluation level. The experimental results show that the convergence speed of DBN based evaluation algorithm is significantly better than that of BP neural network and SVM based evaluation algorithm under the same number of iterations, which is suitable for the accurate evaluation of talent quality.
Design of Distance Learning System for Dance Movement Based on Wireless Network Communication Technology
Authors: Shao Junya , Li Xin
Published: January 2022

The traditional teaching system uses local area network to realize online teaching, which leads to high stability and hardware load of the teaching system and makes it difficult to meet the teaching demand. To solve the above problems, a dance movement distance learning system based on wireless network communication technology is designed. On the B/S architecture, the hardware control module and communication module of the system are designed. The fuzzy set principle is used to evaluate the students’ dance cognitive ability, so as to personalize the recommended teaching contents. The teaching video is compressed according to H.264/AV compression standard to reduce the system transmission and processing load. The system functionality test results show that the maximum transmission packet loss rate of the designed system is 8.3%, and the lost data does not interfere with teaching, has low computer memory consumption, and has superior performance.
A delay nonautonomous model for the effects of fear and refuge on predator–prey interactions with water-level fluctuations
Authors: Sarkar Abhijit , Tiwari Pankaj Kumar , Pal Samares
Published: January 2022

The interaction of prey (small fish) and predator (large fish) in lakes/ ponds at temperate and tropical regions varies when water level fluctuates naturally during seasonal time. We relate the perceptible effect of fear and anti-predator behavior of prey with the water-level fluctuations and describe how these are influenced by the seasonal changing of water level. So, we consider these as time-dependent functions to make the system more realistic. Also, we incorporate the time-dependent delay in the negative growth rate of prey in predator–prey model with Crowley–Martin-type functional response. We clearly provide the basic dynamics of the system such as positiveness, permanence and nonpersistence. The existence of positive periodic solution is studied using Continuation theorem, and suffiecient conditions for globally attractivity of positive periodic solution are also derived. To make the system more comprehensive, we establish numerical simulations, and compare the dynamics of autonomous and nonautonomous systems in the absence as well as the presence of time delay. Our results show that seasonality and time delay create the occurrence of complex behavior such as prevalence of chaotic disorder which can be potentially suppressed by the cost of fear and prey refuge. Also, if time delay increases, then system leads a boundary periodic solution. Our findings assert that the predation, fear of predator and prey refuge are correlated with water-level variations, and give some reasonable biological interpretations for persistence as well as extinction of species due to water-level variations.
Immunity to Invasive Fungal Diseases
Authors: Casadevall Arturo
Published: January 2022

Invasive fungal diseases are rare in individuals with intact immunity. This, together with the fact that there are only a few species that account for most mycotic diseases, implies a remarkable natural resistance to pathogenic fungi. Mammalian immunity to fungi rests on two pillars, powerful immune mechanisms and elevated temperatures that create a thermal restriction zone for most fungal species. Conditions associated with increased susceptibility generally reflect major disturbances of immune function involving both the cellular and humoral innate and adaptive arms, which implies considerable redundancy in host defense mechanisms against fungi. In general, tissue fungal invasion is controlled through either neutrophil or granulomatous inflammation, depending on the fungal species. Neutrophils are critical against Candida spp. and Aspergillus spp. while macrophages are essential for controlling mycoses due to Cryptococcus spp., Histoplasma spp., and other fungi. The increasing number of immunocompromised patients together with climate change could significantly increase the prevalence of fungal diseases.
Novel lncRNA AL033381.2 Promotes Hepatocellular Carcinoma Progression by Upregulating PRKRA Expression
Authors: Wang Feiran , Zhu Lirong , Xue Qiang , Tang Chong , Tang Weidong , Zhang Nannan , Dai Chen , Chen Zhong
Published: January 2022

Hepatocellular carcinoma (HCC) is a common malignant tumor that is characterized by aggressiveness and poor prognosis. Accumulating evidence indicates that oxidative stress plays a crucial role in carcinogenesis, whereas the potential mechanism between oxidative stress and carcinogenic effects remains elusive. In recent years, long noncoding RNAs (lncRNAs) in cancers have attracted extensive attention and have been shown to be involved in oxidative stress response and carcinogenesis. Nevertheless, the roles of lncRNA AL033381.2 in regulating the development and progression of HCC still remain unclear. The purpose of our study was to evaluate the potential effects and molecular mechanisms of AL033381.2 that may be involved in oxidative stress response in HCC. Using bioinformatics analyses based on the TCGA database, we screened and identified a novel lncRNA AL033381.2 in HCC, which may be involved in oxidative stress responses. qRT-PCR analysis revealed that AL033381.2 is upregulated in HCC tissues. Through in vitro and in vivo experiments, we found that AL033381.2 dramatically facilitates the growth and metastasis of HCC. Mechanistically, RNA pull-down experiments, mass spectrometry, PathArray™, and RIP were used to determine that AL033381.2 binds to PRKRA and may be involved in AL033381.2-mediated oncogenic functions in HCC cells. Moreover, rescue experiments demonstrated that PRKRA overexpression rescues the abilities of HCC cell proliferation, migration, and invasion that were affected by AL033381.2 knockdown. Furthermore, we produced a nanoparticle-based siRNA delivery system and tested its therapeutic effects in vivo. The results showed that the in vivo growth rate of the tumors treated with the nanoparticle/AL033381.2 siRNA complexes was dramatically lower than those treated with the nanoparticle/scramble siRNA complexes. Taken together, our results suggest that the novel lncRNA AL033381.2 may be involved in oxidative stress response by targeting oxidative stress-related genes in HCC. AL033381.2 plays vital oncogenic roles in HCC progression and may be a novel therapeutic marker for HCC diagnosis and treatment.
Functional Analysis of Genes GlaDFR1 and GlaDFR2 Encoding Dihydroflavonol 4‐Reductase (DFR) in Gentiana lutea L. Var. Aurantiaca (M. Laínz) M. Laínz
Authors: Yu Tingting , Han Guojun , Luan Zhihui , Zhu Changfu , Zhao Jinghua , Sheng Yanmin
Published: January 2022

Anthocyanins are important pigments for flower color, determining the ornamental and economic values of horticultural plants. As a key enzyme in the biosynthesis of anthocyanidins, dihydroflavonol 4‐reductase (DFR) catalyzes the reduction of dihydroflavonols to generate the precursors for anthocyanidins (i.e., leucoanthocyanidins) and anthocyanins. To investigate the functions of DFRs in plants, we cloned the GlaDFR1 and GlaDFR2 genes from the petals of Gentiana lutea var. aurantiaca and transformed both genes into Nicotiana tabacum by Agrobacterium‐mediated leaf disc method. We further investigated the molecular and phenotypic characteristics of T1 generation transgenic tobacco plants selected based on the hygromycin resistance and verified by both PCR and semiquantitative real‐time PCR analyses. The phenotypic segregation was observed in the flower color of the transgenic tobacco plants, showing petals darker than those in the wild‐type (WT) plants. Results of high‐performance liquid chromatography (HPLC) analysis showed that the contents of gentiocyanin derivatives were decreased in the petals of transgenic plants in comparison to those of WT plants. Ours results revealed the molecular functions of GlaDFR1 and GlaDFR2 in the formation of coloration, providing solid theoretical foundation and candidate genes for further genetic improvement in flower color of plants.
Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma
Authors: Wang Yajuan , Zhu Huizhi , Tong Jiabing , Li Zegeng
Published: January 2022

Objectives. This study sought to examine whether ligustrazine was capable of inhibiting phosphodiesterase (PDE) activity and improving lung function in a rat model of asthma. Methods. Rats were initially sensitized using ovalbumin (OVA) and then were challenged daily with aerosolized OVA beginning 14 days later (30 min/day) to generate a rat model of asthma. Changes in airway function following methacholine (MCh) injection were evaluated by monitoring lung resistance (

R

L

) and dynamic lung compliance (

C

dyn

) values using an AniRes2005 analytic system. In addition, serum IgE was measured via ELISA, while PDE expression was evaluated via qPCR and western blotting. Key Findings. Ligustrazine significantly impaired allergen-induced lung hyperresponsivity and inflammation in this asthma model system. Ligustrazine treatment was also associated with reduced expression of PDEs including PDE4 in the lungs of these rats. Conclusions. Ligustrazine suppresses airway inflammation and bronchial hyperresponsivity in this rat model system, and these changes are associated with decreased PDE expression at the protein and mRNA levels.
Establishment and Application of Pressure Injury Assessment Module in Operating Room Based on Information Management System
Authors: Zhou Fangfang , Wu Zheng , Yu Ying , Xu Lili
Published: January 2022

A pressure injury is a common and painful health condition, particularly among people who are elderly or surgical patients. In order to explore how to use the information management system to optimize the pressure injury management process of surgical patients, this work establishes an integrated pressure injury management information platform for surgical patients, which can effectively control the key links in the process and realize the multistep full-process monitoring of surgical patients from admission to discharge. A total of 578 patients before the operation of the information platform were selected as the control group (CG), and after the operation of the information platform, 662 cases became the observation group (OG). Various evaluation metrics are employed to evaluate pressure injury in terms of single-pass rate, high-risk pressure injury, transfer skin condition description matching rate, hospital pressure injury incidence, and incidence of pressure injury in surgical patients at various stages. The results showed that the qualified rate of the pressure injury assessment in the OG was 99.2%, the accuracy rate of high-risk pressure injury screening and reporting was 100.0%, and the matching rate of the transfer skin description was 100.0%, which was higher than that of the CG. The integrated pressure injury management information platform for surgical patients based on the information management system realizes the full, continuous, accurate, and dynamic evaluation and monitoring of patients’ skin. Furthermore, it can effectively improve the quality of pressure injury care and facilitate care management.
Sensor Mathematical Model Data Fusion Biobjective Optimization
Authors: Hou Maowen , Wang Weiyun
Published: January 2022

Sensors are an important tool to quantify the changes and an important part of the information acquisition system; the performance and accuracy of sensors are more strictly desired. In this paper, a highly sensitive fiber optic sensor for measuring temperature and refractive index is prepared by using femtosecond laser micromachining technology and fiber fusion technology. The multimode fiber is first spliced together with single-mode fiber in a positive pair, and then, the multimode fiber is perforated using a femtosecond laser. The incorporation of data model sensors has led to a rapid increase in the development and application of sensors as well. Based on the design concept and technical approach of the wireless sensor network system, a general development plan of the indoor environmental monitoring system is proposed, including the system architecture and functional definition, wireless communication protocols, and design methods of node applications. The sensor has obvious advantages over traditional electrical sensors; the sensor is resistant to electromagnetic interference, electrical insulation, corrosion resistance, low loss, small size, high accuracy, and other advantages. The upper computer program of the indoor environment monitoring system was developed in a Visual Studio development environment using C# language to implement the monitoring, display, and alarm functions of the indoor environment monitoring system network. The sensor-data model interfusion with each other for mutual integration performs the demonstration of the application.
Targeting Reactive Oxygen Species in Atherosclerosis via Chinese Herbal Medicines
Authors: Zhang Leyi , Huang Jiaqin , Zhang Danli , Lei Xiaojing , Ma Yan , Cao Yun , Chang Jingling
Published: January 2022

Cardio-cerebrovascular disease (CCVD) has become the leading cause of human mortality with the coming acceleration of global population aging. Atherosclerosis is among the most common pathological changes in CCVDs. It is also a multifactorial disorder; oxidative stress caused by excessive production of reactive oxygen species (ROS) has become an important mechanism of atherosclerosis. Chinese herbal medicine (CHM) is a major type of natural medicine that has made great contributions to human health. CHMs are increasingly used in the auxiliary clinical treatment of atherosclerosis. Although their mechanism of action is unclear, CHMs can exert a variety of antiatherosclerosis effects by regulating intracellular ROS. In this review, we discussed the mechanism of ROS regulation in atherosclerosis and analyzed the role of CHMs in the treatment of atherosclerosis via ROS.
Deep Convolutional Nets Learning Classification for Artistic Style Transfer
Authors: Dinesh Kumar R. , Golden Julie E. , Harold Robinson Y. , Vimal S. , Dhiman Gaurav , Veerasamy Murugesh
Published: January 2022

Humans have mastered the skill of creativity for many decades. The process of replicating this mechanism is introduced recently by using neural networks which replicate the functioning of human brain, where each unit in the neural network represents a neuron, which transmits the messages from one neuron to other, to perform subconscious tasks. Usually, there are methods to render an input image in the style of famous art works. This issue of generating art is normally called nonphotorealistic rendering. Previous approaches rely on directly manipulating the pixel representation of the image. While using deep neural networks which are constructed using image recognition, this paper carries out implementations in feature space representing the higher levels of the content image. Previously, deep neural networks are used for object recognition and style recognition to categorize the artworks consistent with the creation time. This paper uses Visual Geometry Group (VGG16) neural network to replicate this dormant task performed by humans. Here, the images are input where one is the content image which contains the features you want to retain in the output image and the style reference image which contains patterns or images of famous paintings and the input image which needs to be style and blend them together to produce a new image where the input image is transformed to look like the content image but “sketched” to look like the style image.