bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge about cholera and its prevention among household heads in a highly urbanized city in Western Philippines: a cross-sectional study
Authors: Oscares Karen Joy S. , Pacubas Sarah Adelaide S. , Padpad Felb Audrey Hope G. , Paglomutan Precious Angel A. , Panelo Pearl Krystelle R. , Oducado Ryan Michael Flores
Published: June 2024

Introduction: Cholera remains a significant public health threat globally, but its impact can be significantly reduced with the right knowledge and correct preventive practices. Conducting a study to provide baseline data and identify knowledge gaps on cholera will benefit at-risk and vulnerable communities. This research aimed to determine the household heads' knowledge about cholera and its prevention in a barangay in the Western Philippines.
Methods: A cross-sectional survey using a questionnaire was conducted in an urban barangay in Iloilo City in Western Philippines among 252 randomly selected household heads in May 2023. Data were described, and t-Test for independent samples and one-way ANOVA were used to test for differences.
Results: The majority of household heads were generally knowledgeable about cholera and its prevention, but only 51.2% knew that oral rehydrating solution (ORS) could help manage symptoms of cholera. Furthermore, there was a significant difference in knowledge about cholera and its prevention based on sex (t = 2.92; p = 0.004).
Conclusions: Household heads understood well and were informed of cholera and its prevention, although there were still some misconceptions. Continuous health education and knowledge assessment are recommended to raise awareness and ensure correct and timely information dissemination regarding cholera.
Initiation of self-care practices in heart failure patients: a phenomenological study
Authors: Suharsono Tony , Ulya Ikhda , Yona Sri , Siswanto Bambang Budi
Published: June 2024

Introduction: The incidence of heart failure continues to rise with advancing age, unabated by advancements in healthcare technology. Patients with heart failure are required to manage their care independently at home for the remainder of their lives. This study aimed to delve into the experiences of heart failure patients regarding self-care management at home.
Methods: Nineteen patients with heart failure were chosen through purposive sampling and thorough interviews were conducted to collect their self-care treatment experiences. Content analysis was carried out to scrutinize the acquired data.
Results: The analysis revealed four themes: patients' perception of heart failure diagnosis, efforts in self-care, readiness for self-care, and adoption of new healthy behaviors in heart failure. Eight categories were formulated within these themes, including “transitioning into a heart failure patient;” “recognizing the need for self-care;” “seeking information and heart failure therapy;” “facilitators and barriers in seeking information regarding self-care;” “social support and belief in engaging in self-care at home;” “self-confidence in engaging in self-care at home;” “efforts to develop self-care strategies;” and “engaging in new healthy behaviors as heart failure patients independently.”
Conclusions: Patients become aware of the necessity for self-care upon experiencing discomfort due to symptoms resulting from their heart failure. Family support and the patient's belief system play pivotal roles in initiating self-care practices at home. Nurses should provide support to patients in fostering self-care practices within their homes.
The predictor of non-suicidal self-injury behavior among adolescents: a cross-sectional study
Authors: Iswanti Dwi Indah , Lai Lee-Lee , Saifudin I Made Moh. Yanuar , Kandar Kandar , Dewi Rian Kusuma , Cahyaningrum Dessy Dwi
Published: June 2024

Introduction: Non-Suicidal Self-Injury (NSSI) among adolescents is a prevalent issue in Indonesia. Comprehensive understanding of NSSI is essential for uncovering the factors that trigger and predispose adolescents to such behavior. This knowledge serves as a foundation for crafting targeted nursing interventions to address and mitigate NSSI among this vulnerable population. This study aimed to identify determinant factors contributing to the occurrence of Non-Suicidal Self-Injury behavior in adolescents.
Methods: The study employed a cross-sectional approach conducted between October and December 2023, with 570 respondents selected through simple random sampling. Socio-demographic, precipitating, and predisposing factors were measured using a checklist sheet. The Self-Harm Inventory (SHI) instrument was utilized to assess NSSI. Data analysis involved Pearson correlation and multiple regression to examine the relationships between variables.
Results: The study revealed significant relationships among five variables. Gender (p-value = 0.004), bullying (p-value = 0.002), disappointment (p-value = 0.001), sharing place (p-value = 0.002), and communication pattern (p-value = 0.010) were identified as factors associated with Non-Suicidal Self-Injury behavior in adolescents. On the other hand, personality (p-value = 0.174), environment (p-value = 0.260), coping mechanism (p-value = 0.458), and parenting style (p-value = 0.054) showed no association with Non-Suicidal Self-Injury behavior.
Conclusions: The findings underscore the significance of disappointment and the absence of a supportive environment in influencing NSSI. This highlights important considerations for healthcare professionals, educators, and policymakers. Strategies should encompass comprehensive approaches, early detection, and targeted interventions to foster supportive environments and address the complex nature of NSSI among adolescents.
ANALYSIS OF THE LETHALITY OF POLYTRAUMA IN MULTIDISCIPLINE HOSPITAL
Authors:   Kazan State Medical University, CHIKAEV VYACHESLAV F. , AKHTYAMOV ILDAR F. ,   Kazan State Medical University, PETUKHOV DENIS M. ,   City Clinical Hospital No. 7, Kazan, DELYAN ARTUR M. ,   City Clinical Hospital No. 7, Kazan, SADRIEV RAFAT R. ,   City Clinical Hospital No. 7, Kazan, ISMAGILOV DAMIR O. ,   City Clinical Hospital No. 7, Kazan
Published: June 2024

Abstract. Introduction. Severe concomitant trauma is one of the most difficult problems of modern medicine due to high mortality. The analysis of the structure of lethality and its causes can help to improve the effectiveness of care for combined trauma. Aim. The aim was to analyze the causes of mortality of patients with combined injuries in a multidisciplinary hospital of level 3. Material and methods. We studied the nature of injuries and the causes of death of 117 patients with fatal polytrauma hospitalized in the city municipal hospital № 7 in Kazan. The severity of the patients’ condition, the features of anatomical injuries, the causes, the nature of complications, depending on the duration of mortality, were studied. Results and discussion. In the structure of injuries in the patients with polytrauma and fatal outcome, the leading one was craniocerebral trauma 73,5% (n=86). Of these, 76,7% (n=66) cases were diagnosed with severe brain contusion. Injury scale was 28,5±8,4. The second position among the injuries was occupied by a chest injury, 57,2% (n=67). Injuries of the musculoskeletal system were characterized by severe and moderate traumas, injury scale was 4–9 points. Abdominal trauma was detected in 18,8% (n=22) cases. In the patients, due to the impact of mechanical damage, blood loss, peripheral and central respiratory disorders in the early post-traumatic period, central hemodynamic disorders, hypovolemia, we see developing hypoxia in most of the tissues. All this leads to a cascade pathogenetic process and is characterized by hypothermia, metabolic and metabolic disorders, hypocoagulation. Conclusion. The main cause of death of patients with combined trauma is severe mechanical damage, excessive afferent nociceptive impulses, accompanied by a breakdown of the compensatory capabilities. Blood loss leads to perfusion disorders, coagulopathy, hemic hypoxia, and irreversible changes in the tissues. Severe brain contusion, chest trauma intensify hypoxia due to central and peripheral respiratory disorders. At late period, the cause of death is multiple organ failure and related complications.
ANALYSIS OF SKIN GRAFTING METHODS FOR EXTENSIVE BURNS OF THE MIDDLE AND LOWER THIRD OF THE FACE
Authors:   Voronezh State Medical University, PAVLYUCHENKO SERGEY V.
Published: June 2024

Abstract. Introduction. The article analyzes the most advanced approaches to the choice of plastic replacement of burn defects in the middle and lower thirds of the face and neck. Aim. The aim is to review of current data on the analysis of autograft transplantation technique and algorithm depending on the specific surgical school. Material and methods. A review of current medical publications in foreign literature for the last 5 years has been carried out. Results and discussion. Further prospects for the use of allogeneic and synthetic materials, which are auxiliary tools necessary to optimize the technology of skin graft engraftment, are evaluated. A comparative assessment of the methods in which skin grafts were used with methods based on the use of free skin flaps and local flaps, previously expanded with a tissue expander, was made. Conclusion. According to the literature, the most suitable flaps for face transplantation have been identified, depending on the aesthetic aspects of the initial defect and the anatomical features of the blood supply sources of both the donor zone and the recipient bed. In connection with recent advances in the field of allotransplantation of the face, which marks the beginning of a new period in reconstructive surgery of the face, significant shortcomings and, at the same time, undoubted advantages of this technique have been noted.
Factors Influencing the Intention of COVID-19 Infection Preventive Behaviors Among Hemodialysis Patients in Korea: A Cross-sectional Study
Authors: Ham Su In , Lee Kyu Eun
Published: June 2024

Objectives: This study aimed to identify the factors influencing the intention of COVID-19 infection preventive behaviors among patients undergoing hemodialysis by applying the theory of planned behavior. Methods: The study included 209 patients with chronic renal failure undergoing hemodialysis at five hospitals in Gangwon-do, Korea. Data were collected from December 28, 2021 to January 15, 2022. The analysis involved percentage, mean and standard deviation, independent t-test, ANOVA, Pearson’s correlation coefficient, and hierarchical multiple regression using SPSS 22.0. Results: Significant correlations were observed between attitude toward COVID-19 preventive behavior, subjective norms regarding COVID-19 preventive behavior, perceived behavior control of COVID-19 preventive behavior, restricted dietary control, COVID-19 knowledge, self-efficacy in COVID-19 preventive behavior, and intention of COVID-19 infection preventive behavior. Hierarchical multiple regression analysis revealed that subjective norms regarding COVID-19 preventive behavior (β = 0.49, p < 0.001) and perceived behavior control of COVID-19 preventive behavior (β = 0.26, p < 0.001) significantly influenced the intention of COVID-19 infection preventive behavior among hemodialysis patients. The model accounted for 54.8% of the variance (F = 43.02, p < 0.001). Conclusions: Identifying relevant factors associated with COVID-19 preventive behaviors among vulnerable hemodialysis patients is crucial for providing adequate care by healthcare professionals. Proactive measures are necessary to prevent and manage the infection in this patient population.
Factors Affecting Quality of Life of One-person Household Adults: Based on the 8th Korean National Health and Nutrition Examination Survey
Authors: Chung Soojin , An Bomi
Published: June 2024

Objectives: The aim of this study is to examine health-related behaviors, and mental health of one-person household adults and health-related quality of life levels, and investigate factors influencing their health-related quality of life. Methods: A Secondary data from the 8th Korean National Health and Nutrition Examination Survey (2019, 2021) were used for data analysis. Data from 839 one-person household adults aged over 20 were analyzed. Hierarchical regression analysis was conducted to explore risk factors on quality of life. Results: Among single-person household adults, the study found that the smoking rate was 33.4%, with an alcohol consumption rate of 66.9%. Additionally, approximately 50.9% engaged in regular physical activity, 32.2% reported experiencing much stress, and 7.5% had experienced suicidal ideation. The overall quality of life was 0.81 out of 1 point. The factors influencing the quality of life were age, income, occupation, stress, and suicidal ideation. Conclusions: It appears that we need to identify whom have no job, low income, with high levels of stress and suicidal thoughts, from their early adulthood in single-person householdsand and to have attention and support for the health-related quality of life.
Alkali-activated cements based on limestone-fly ash: Effect of the MgO-NaOH activation, compressive strength and reaction products
Authors: Betancourt- Castillo Irma Elizabeth , Burciaga-Díaz Oswaldo
Published: June 2024

This study investigates the effects of alkaline activation with MgO-NaOH on the compressive strength and reaction products of alkali activated cements of limestone powder (PClz) and Class C fly ash (CV). Results showed that substitutions of 25%<PClz<75% allowed 25-76 MPa at 360 days of curing, obtaining the highest strength with 25%PClz-75%CV and 50%PClz-50%CV with 10 and 12% NaOH-MgO, respectively. The results suggest that PCLz participates in hydration reactions as filler and nucleating agent while CV is the main contributor to the advance of the chemical reactions. X-ray diffraction (XRD), Thermal analysis (TA) and Scanning Electron Microscopy (SEM) indicated the formation of M-S-H, and C, N-A-S-H-type products, in addition to carbonate phases such as hydrotalcite, gaylussite, and pirssonite. Traces of unreacted MgO were not observed indicating its whole incorporation into the reaction products.
Maximizing Workshop Efficiency Reusing Old Compressors Globally
Authors: Kurniawan Bagus , Mulyadi
Published: June 2024

This study investigates the feasibility of repurposing old refrigerator compressors to construct an air compressor for workshop use. Conducted at the Laboratory of Mechanical Engineering, Muhammadiyah University of Sidoarjo, the research assesses performance factors such as compressor tube filling time and injection settings. Results indicate that using one compressor motor takes 12 minutes and 57 seconds to fill the tube, while two motors reduce this to 8 minutes and 12 seconds, reaching a maximum pressure of 75 psi. Higher spray gun settings result in faster air depletion. Although pressure output is weaker compared to conventional compressors, the cost-effectiveness of using reused materials is evident, highlighting potential economic and environmental benefits.
 
Highlight: 
Repurposing old compressors for workshop air supply.
Assessing performance: filling time, injection settings.
Cost-effective, eco-friendly solution for workshop equipment.
 
 
Keyword:  Repurposing, Refrigerator Compressors, Workshop Equipment, Performance Assessment, Cost-effectiveness
Systematic RPG Development Maximizes Player Engagement in Global Context
Authors: Hidayatullah Vika Tanjung , Astutik Ika Ratna Indra , Ariyanti Novia , Busono Suhendro
Published: June 2024

This study presents the systematic development of an Adventure RPG game titled "Tomorrow Will Come" using the ADDIE method, aiming to enhance understanding of RPG game development. Leveraging the Godot Engine and GDscript programming language, the research follows the Analysis, Design, Development, Implementation, and Evaluation phases. Feedback from beta testers highlights positive gameplay experiences but suggests room for improvement, particularly in gameplay difficulty. The findings underscore the significance of iterative design and player feedback in refining game mechanics. Overall, this research contributes to advancing RPG game development methodologies and emphasizes the importance of innovation and user-centric design in creating compelling gaming experiences.
 
Highlight: 
1. ADDIE method enhances structured RPG game development.
2. Player feedback refines mechanics, enhancing overall quality.
3. Godot Engine innovates technical aspects, prioritizing user-centric design.
 
 
Keyword:  RPG game development, ADDIE method, Godot Engine, Player feedback, Iterative design
Pengaruh Pendekatan Pembelajaran Problem Posing terhadap Kemampuan Berpikir Kritis Matematis Siswa
Authors: Alani Nabella
Published: June 2024

Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan pengaruh implementasi pembelajaran dengan pendekatanproblem posing terhadap perolehan kemampuan berpikir kritis matematis siswa. Metode dalam penelitian ini adalah kuantitatif dengan jenis Quasi Experimen. Dalam penelitian ini diperoleh kesimpulan (i) pendekatanproblem posing berpengaruh terhadap kemampuan berpikir kritis matematis siswa, (ii) pendekatanini juga terbukti dapat meningkatkan kemampuan berpikir kritis matematis siswa, hal ini didapatkan berdasarkan uji N-gain yang telah dilakukan dimana perolehan skor N-gain untuk pendekatan problem posing yakni sebesar 0.67 yang termasuk ke dalam kategori sedang. Maka berdasarkan hasil penelitian dapat disimpulkan bahwa pendekatan pembelajaran problem posing berpengaruh terhadap kemampuan berpikir kritis matematis siswa, selain itu pendekatan pembelajaran ini pun dapat meningkatkan kemampuan berpikir kritis matematis siswa.
Deriving the PedsUtil Health State Classification System to Measure Health Utilities for Pediatric Populations Based on the PedsQL: A Confirmatory Factor Analysis
Authors: DeLuca Ellen Kim , Dalziel Kim , Wittenberg Eve , Rose Angela M. , Prosser Lisa A.
Published: June 2024

Background: An important methodological challenge in conducting pediatric economic evaluations is estimating the preference-based health-related quality of life (HRQoL) of children. Current methods are highly variable and there is no single instrument available to value HRQoL consistently across multiple pediatric age groups. The PedsQL is a non-preference-based generic HRQoL instrument validated for children 2-18 years, but it cannot be directly used in economic evaluations. The aim of this study was to establish the core dimension structure of the PedsUtil health state classification system using confirmatory factor analysis, which is the first step of deriving a preference-based measure of HRQoL based on the PedsQL.
Methods: Four competing dimension structures of the PedsUtil health state classification system were developed based on published literature and expert opinion. Using data from the Longitudinal Study of Australian Children (LSAC) (n = 45,207), the 4 dimension structures were evaluated using the robust weighted least squares estimation method. The analyses were stratified by 2-year age intervals (from 2 to 17 years) to reflect the study design of the LSAC, as well as special healthcare needs status of the child. Model fit was evaluated by examining standardized factor loadings and various fit indices including the comparative fit index (CFI), Tucker-Lewis Index (TLI), and the root mean square error of approximation (RMSEA). Modification indices and residual correlations were examined to re-specify the models to improve model fit when necessary.
Results: The findings supported a 7-dimension structure (i.e., Physical Functioning, Pain, Fatigue, Emotional Functioning, Social Functioning, School Functioning, and School Absence) of the PedsUtil health state classification system. The 7-dimension model exhibited adequate fit across subgroups with CFI values that ranged from 0.929 to 0.954, TLI values from 0.916 to 0.946, and RMSEA values from 0.058 to 0.102.
Conclusions: This study established the core dimension structure of the PedsUtil health state classification system using confirmatory factor analysis. The 7-dimension structure was found to be applicable across diverse pediatric populations. Research is currently ongoing to select the most representative item within each dimension of the PedsUtil health state classification system and valuation surveys will be fielded to estimate the PedsUtil scoring system.
Ag+ ions are effective elicitors for enhancing the production of phenolic acids and tanshinones in Salvia aristata Aucher ex Benth. hairy roots
Authors: Rahchamani Raziey , Radjabian Tayebeh , Abrishamchi Parvaneh
Published: June 2024

Salvia aristata Aucher ex Benth., due to containing tanshinones and phenolic acids, two main groups of bioactive metabolites, is one of the most valuable medicinal plant species in Iran. In this study, for the first time, hairy root (HR) cultures were established from 14-day-old seedlings inoculated with Agrobacterium rhizogenes strain ATCC 15834. Additionally, the effects of elicitation with Ag+ ions (15 and 25 µM) were investigated on the growth indices and content of phenolic acids and tanshinones of HRs in a time-course experiment. The findings of this work showed that exposure of HRs to Ag+ at both concentrations caused significant increases in the levels of rosmarinic acid (1.34- to 1.43-fold of control) and salvianolic acid B (1.71- to 1.82-fold of control). Specifically, 7.25-, 7.78-, 6.47-, and 3.9-fold increases were attained in total tanshinone, tanshinone I, tanshinone II-A, and cryptotanshinone contents of HRs, respectively, after seven days of exposure to 25 µM Ag+ ions compared to the control groups. The analysis revealed that exposure to Ag+ ions significantly enhanced the secretion of tanshinones, notably tanshinone II-A (31.49 ± 0.65 µg mL− 1) by HRs into the culture medium. The changes in transcript levels of crucial genes in the biosynthesis pathways of phenolic acids (PAL, TAT, and RAS) and tanshinones (CPS and CYP76AH1) were associated with their contents in HRs under elicitation with Ag+ ions. Our findings confirmed the effectiveness of an elicitation strategy to improve metabolite production in HR cultures of S. aristata as potent natural sources of phenolic acids and tanshinones.
miRNA-193a acts as a tumor suppressor in human head and neck cancer cells and inhibits tumor development in xenograft mice
Authors: Fares Fuad , Miari Reem , Azzam Naiel , Shalom Rinat Bar , Napso Tina , Ronen Ohad
Published: June 2024

miRNAs are small non-coding RNA molecules, involved in the regulation of gene expression via binding to messenger RNA (mRNA), thereby preventing protein translation. We found that the promotor region of miR-193a is highly methylated in FaDu head and neck cancer cells, assuming that its expression is suppressed. Moreover, our results indicated that miRNA-193a levels are undetectable in biopsies of head and neck cancer patients. Induction of miR-193a expression by treatment with methyltransferase inhibitor or transduction of head and neck squamous cell carcinoma (HNSCC) cells with miR-193a resulted in a significant decrease in cell viability in a dose and time-dependent manners, as well as induction of apoptosis through the caspase intrinsic pathway. Moreover, miR-193a also inhibited tumour growth in xenograft mice transplanted with FaDu cells. In addition, we found that miR-193a inactivates the AKT/mTOR signaling pathway through the downregulation of PIK3R3, mTOR, S6KB2, and ERBB4. These observations suggest that miR-193a plays an important role in tumor biogenesis and therefore has the potential to serve for diagnostics as well as therapeutics in HNSCC.
Analysis of the influence of pipe materials on the energy separation effect of vortex tubes
Authors: Han Zhihong , Huang Zhiyuan
Published: June 2024

The basic objective of studying vortex tubes using CFD simulations is to improve efficiency and performance by selecting the right material for manufacturing vortex tubes under suitable conditions. In this paper, numerical simulations are carried out to analyze the counter flow vortex tube with different materials. Compressed air is used as the work mass with an inlet pressure of 0.1mpa to 0.5mpa and the materials used are copper, aluminum, steel, PVC, and wood. The cold mass fraction was kept at 0.1, and the L/D of the vortex tube was taken as 16. The Standard k-ε model was used to perform steady-state numerical simulations of the gas flow inside the vortex tube, and the trends of velocity, pressure, and temperature variations under different materials, pressures, and roughness conditions were obtained. Finally, after evaluating all the simulated values for the properties of the five materials, depending on their physical properties, the vortex tube as a metallic material has a higher temperature gradient than the non-metallic materials in the order from copper - aluminum - steel - PVC - wood.
Resilience and coping during protracted conflict: A comparative analysis of general and evacuees populations
Authors: Marciano Hadas , Kimhi Shaul , Eshel Yohanan , Adini Bruria
Published: June 2024

Background
On October 7, 2023, Hamas launched a surprise attack on Israel, triggering a conflict with Israel in the Gaza Strip. This ongoing war, now six months old, has also seen threats from Hezbollah in Lebanon, as well as from Yemen and Iran. The precarious security situation along Israel’s southern and northern borders led to extensive evacuations, with residents relocating within Israel under uncertain conditions concerning their return and property safety. This study compares resilience (societal, SR; community, Cr, and individual, IR), hope, morale, distress symptoms (anxiety and depression symptoms), and perceived danger between general Hebrew-speaking adults and evacuee adults a few months post-conflict initiation.
Methods
Data was gathered via structured questionnaires focused on resilience and coping strategies, administered through two online panel companies. The general population data was collected from January 14–21, 2024 (N = 1,360), and the evacuees' data from March 1–9, 2024 (N = 372; 133 from the north, 239 from the south).
Results
Evacuees reported lower SR and CR, hope, and morale, but higher distress symptoms and perceived danger compared to the general population. No differences in IR were found. Regression analyses identified different primary predictor of SR for each group: hope for the general population and governmental support for evacuees. Additionally, IR significantly predicted outcomes only among evacuees, whereas age, religiosity, and education were significant predictors solely in the general population. One notable similarity emerged: CR served as the second most influential predictor in both samples.
Conclusions
The entire population of Israel is affected by the ongoing war, yet evacuees endure a disproportionately severe impact, with potential for increased harm as the conflict persists. The adjustment to a new wartime emergency routine is more complex for evacuees than for the general population. It is crucial for policy and decision-makers to address the distinct differences between evacuees and the general populace to effectively meet their specific needs. Yet, it should be acknowledged that the evacuees represent a heterogenic group, necessitating a detailed subdivision into subgroups to accurately assess and address their unique challenges.
Shear wave elastography of the supraspinatus tendon with early degeneration in asymptomatic type II diabetes mellitus patients: a multicenter study
Authors: Wang Tong , He Yanni , Yi Wenhong , Xie Huiyu , Wang Dan , Zeng Jie , Liang Jinying , Chen Yufan , Mo Qiuyan , Zhou Meijun , Li Sushu , Huang Feifei , Liu Shaoming , Ma Liya , Liu Xueling , Liu Hongmei
Published: June 2024

Objectives This study aimed to explore conventional ultrasound sonography and shear wave elastography (SWE) changes in the supraspinatus tendon in type 2 diabetes patients (T2DM) without shoulder pain. The factors influencing supraspinatus tendon thickness and shear wave velocity (SWV), which are measured by SWE, were also explored.
Methods This multicenter study recruited nonshoulder pain individuals, including healthy and diabetic patients from March 2021 to October 2022. Propensity score matching was used to overcome selection bias. The thickness and SWV of the bilateral supraspinatus tendons were measured, and their influencing factors were evaluated via regression analysis. The sonography and blood flow signals were observed and compared via χ2 tests.
Results A total of 107 T2DM patients and 270 healthy people were enrolled (mean age, 42 years +/- 14, 162 men). Although 59.8% of T2DM patients without shoulder pain, they were likely to have degenerative ultrasonic image and a lower SWV (-0.529 [-0.827, -0.232] vs. 1; p = 0.001) than healthy people, but no difference was detected for uneven thickening of the tendon (p = 0.055) or blood flow signals (p = 0.060).
Furthermore, subjects > 50 years old, with a BMI ≥ 25.0 and who were of Zhuang nationality had thicker supraspinatus tendons than did the controls. Han individuals and regular upper limb exercise subjects had greater tendon SWV than did controls.
Conclusions SWE is a repeatable and early tool for assessing supraspinatus tendon degeneration in asymptomatic patients with T2DM. Active control of the condition of diabetes patients and regular upper limb exercise might help delay the degeneration of supraspinatus tendons.
Comparison of Low-Pressure and Standard-Pressure Pneumoperitoneum Laparoscopic Cholecystectomy in Patients with Cardiopulmonary Comorbidities: A Double Blinded Randomized Clinical Trial
Authors: Tian Feng , Sun Xiaowei , Yu Yang , Zhang Ning , Hong Tao , Liang Lu , Yao Bihui , Song Lei , Pei Changhong , Wang Yu , Lu Wenlong , Qu Qiang , Guo Junchao , Zhang Taiping , He Xiaodong
Published: June 2024

Background
The safety and efficacy of low-pressure laparoscopic cholecystectomy (LPLC) in patients with cardiopulmonary comorbidities remain unclear.
Methods
This was a multicenter, parallel, double-blind, randomized controlled trial performed from January 1, 2019, to January 31, 2023. Eligible patients included patients with cardiac or pulmonary comorbidities, who were randomly assigned (1:1) to undergo LPLC (10 mmHg) or standard-pressure laparoscopic cholecystectomy (SPLC) (14 mmHg). The primary outcome was intraoperative surgeon comfort. Surgical safety variables, patient recovery, and pulmonary function parameters were also compared between groups.
Results
This study enrolled 144 participants, with 124 participants extracted for the final analysis (62 in LPLC and 62 in SPLC group, respectively). Similar proportion of surgeons reported excellent working space and surgical view (90.3% in the LPLC and 98.4% in the SPLC groups, respectively, p = 0.114). There was no between-group difference regarding intraabdominal operative time, rate of intraoperative bile spillage, blood loss, and conversion rate. Moreover, postoperative major complication rates, the median time to the first flatus, postoperative hospital stay, or mean postoperative visual analog scale score for pain were similar in both groups. Pulmonary parameters including postoperative pH, PaCO2, HCO3, and lactate levels were similar between the two comparing groups.
Conclusions
LPLC with a pneumoperitoneum pressure of 10 mmHg is safe and reasonable for patients with cardiopulmonary comorbidities.
Registration:
The trial is registered at ClinicalTrials.gov (NCT04670952).
The Model of Digital Pedagogies and Digital Quality Management in practically oriented Higher Education Institutions (HEIs). The case of Laurea University of Applied Sciences.
Authors: Ulatowska Roksana , Sułkowski Łukasz , Bilan Svitlana
Published: June 2024

The Industrial Revolution 4.0 and the ongoing development of technology result in a digital transformation which forces higher education institutions (HEIs) to introduce significant changes. These changes necessitate a new approach that encompasses not only learning methodologies but also the university’s culture, strategy, and systemic activities. In this article we present a new, unique model of Digital Pedagogies and Digital Quality Management exemplified by the case applied approach. The model shows the intersection of the‘Digital learning foundation’,‘ Enabling factors’(digital flexibility and digital learning tools),‘Systematic quality of learning management’ and ‘Challenges of Digital Flexibility’ in HEIs. The proposed model applies practices and recommendations for Universities of Applied Sciences, making it worth disseminating in this context. The model can be useful and beneficial for facilitating peer-to-peer networking in practically oriented HEIs. The results section discusses the empirical results, supported by direct quotes from interviewees and structured codifications and proposition of model dynamics. The final section of the article describes key conclusions and limitations of the model. This study provides valuable insights for university authorities, educators, and policymakers on how digital transformation influences digital pedagogies, quality management, and finally the transition of HEIs.
An Evolutionary Prediction Model for Enterprise Basic Research Based on Knowledge Graph
Authors: Haican Diao , Yanqun Zhang
Published: June 2024

Currently, China's enterprise basic research faces problems due to a need for more systematic guidance and dispersed themes. The construction of an enterprise basic research knowledge map is of great practical significance for tracking cutting-edge technologies, tapping the primitive scientific and technological innovation ability of enterprises, and playing the leading role in enterprise innovation. By mining the intrinsic correlation between the data, a multilayer CNN-LSTM-based correlation prediction model for enterprise basic research is proposed, using the number of published papers of enterprises as the experimental dataset, reasoning and completing the knowledge graph of enterprise basic research, and predicting the future direction of enterprise basic research; and constructing a probability calculation model of enterprise basic research with a multi-attention mechanism, and probabilistically calculating the future hotspot direction of enterprise basic research. The experimental results show that compared with the existing classical model, the recall and F1 value of the multilayer CNN-LSTM evolutionary prediction model are significantly improved. It can more accurately capture the cutting-edge research topics in several types of basic research fields, which provides a new perspective for the related personnel to predict the trend of basic research fields.
Evaluating the Relationship between Periodontal Bone Loss in Maxillary Posterior Teeth and Schneiderian Membrane Thickness
Authors: Ekşi Cemre , Şeker Başak
Published: June 2024

Background
To understand the potential impact of periodontal disease on maxillary sinus health, this study aimed to evaluate the relationship between periodontal bone loss and maxillary sinus membrane thickness using cone beam computed tomography (CBCT).
Methods
Nine hundred thirty-nine maxillary posterior segment images from 527 subjects were retrospectively scanned via CBCT. A total of 826 premolar, 701 first molar and 817 second molar teeth were examined. The maxillary sinuses in each segment were divided into anterior, median and posterior regions according to the tooth roots they were associated with and their membrane thicknesses were measured and categorized. The effects of age and sex on membrane thickness were evaluated. T tests and one-way ANOVA were used to analyze differences between groups, followed by post hoc Tukey tests for multiple comparisons. Additionally, correlation analyses were performed to investigate the relationships between the categorized membrane thicknesses and periodontal bone loss.
Results
A significant positive correlation was found between maxillary sinus membrane thickness and periodontal bone loss in all three regions (p < 0.05). Periodontal bone loss was greater in regions with class IV membrane thickness (p < 0.001). Sinus membrane thickness and periodontal bone loss were greater in men (p < 0.001) and older people (p < 0.05).
Conclusions
This study found a relationship between maxillary sinus membrane thickness and bone loss due to periodontal disease in the maxillary posterior region. Considering the relationship between periodontal disease and sinus infections, it can be concluded that progressive and untreated periodontal disease may be associated with infections in close anatomical structures such as the maxillary sinus. These results may contribute to the development of clinical decisions and treatment plans in implantology practices.
Facile Fabrication of Polymer/Palygorskite Microcapsules via Pickering Emulsion Photopolymerization
Authors: Li Jin , Wang Xinyang , Zhang Pengying , Chen Quan , Min Dandan , Jiang Xiaowu , Gao Xiaoyan , Ni Lingli
Published: June 2024

A facile photocatalytic Pickering emulsion polymerization process was developed to fabricate polymer/clay composite microcapsules. Photolatent Pickering emulsions of oil (monomer, crosslinker, Irgacure 819 and octane) in water were prepared using palygorskite fibers (PAL) as particulate emulsifier. The effect of PAL concentration on the emulsion stabilities was well studied. 3 wt% of PAL fibers were required in order to obtain a stable Pickering emulsion. Moreover, serials of factors on the formation of microcapsules have been investigated, such as PAL concentration, photoinitiator percentage, light intensity, crosslinker/monomer radio and monomer type. Under the appropriate conditions, polymer/PAL microcapsules with spherical morphology can be produced easily. Consequently, a formation mechanism of the microcapsules has been proposed.
Two-step Ulm-Chebyshev-like method for inverse singular value problems with multiple singular values
Authors: Ma Wei , Zhu Yuqing , Dang Yawei
Published: June 2024

In this article, when the given singular values are positive and multiple, we study the convergence of two-step Ulm-Chebyshev-like method for solving the inverse singular value problems is obtained, which extends the result of Ma (2022) [1]. We show that the new method is cubically convergent. Moreover, numerical experiments are given in the last section, which show that the proposed method is practical and efficient.
AMS subject classification. 65F18, 65F15, 15A18
The rate of dunes erosion on the Southern Baltic Sea coast under the influence of the Marie and Nadine double storm in January 2022
Authors: Labuz Tomasz Arkadiusz
Published: June 2024

The paper discusses the conditions for development and the course of the double storm surge caused by the Marie and Nadine cyclones in January 2022. Smaller surges that preceded the main large one have also been presented. The volume of coastal dune erosion caused by storm surges, including the sea level height and wave run-up were analysed, as was the influence of the ratio of beach height to run-up and the volume of dune erosion. The results were obtained based on field measurements of the changes in the morphology of the coast and the waterfront on various sections of the Polish coastline. The dune retreat after selected surges was calculated. The largest dune erosion occurred after the Marie and Nadine storms. The maximum sea level was 1.28 m AMSL. At that height, the water run-up on the coast reached 3-3.2 m AMSL. Mean erosion, defined as the retreat of the dune base, was 4.3 m. However, it was higher in sections where the beach was lower than the water run-up during surges and ranged from 4 to 8 m. Dune erosion reaching up to 8 m occurred on so-called cape sections, where the direction of the coastline changes. The factors that influenced the volume of dune erosion were the different levels of the sea and run-up, as well as the coast’s exposure to waves and the beach height.
High blood pressure in the Emergency Department as an opportunistic screening tool for detection of hypertension
Authors: Bentzel Sara , Manhem Karin , Öhman Ottilia , Abdulla Karzan , Mourtzinis Georgios
Published: June 2024

Hypertension is the most preventable cause of morbidity and mortality, but many individuals are not diagnosed and lack treatment control. High blood pressure (BP) in the emergency department (ED) is commonly observed, but mostly used for short-term evaluation. We aimed to study the usefulness of high BP in the ED as a screening tool for undiagnosed hypertension.
We used the electronic medical record system to identify all patients that had attended the ED at a university hospital from 2018-01-01 to 2018-03-31 and from 2018-07-01 to 2018-09-30 with an obtained BP ≥160/100 mmHg measured at the ED. We excluded patients with previously diagnosed hypertension and patients on any BP-lowering medication. All patients identified where contacted two years after attending the ED, with a letter of consent and a questionnaire regarding diagnosis of hypertension and current medication.
5424 patients attended the ED during the 6-months-period. A total of 271 patients met the inclusion criteria and were asked to participate. 167 individuals (62%) agreed to participate and responded to the questionnaire. Mean age of participants were 63.1 years and 51% were women. 134 patients (80%) had measured their BP after the ED-visit, and 48 (36%) of those had been diagnosed with hypertension. 96% of patients diagnosed with hypertension were on BP-lowering medication.
To follow-up BP ≥160/100 mmHg after an ED visit can reveal undiagnosed hypertension in one third of the patients. Given the amount of undiagnosed hypertension, an ED-measured BP might provide an important tool to detect and start treatment of hypertension.
How Learners’ Trust Changes in Generative AI Over a Semester of Undergraduate Courses
Authors: Song Donggil
Published: June 2024

Artificial intelligence (AI) applications, including advanced machine learning (ML), have received attention in education, and generative AI-powered chatbots like ChatGPT and Copilot have been adopted in diverse educational settings worldwide. However, the actual use of and perception regarding AI-powered chatbots by learners have been under-investigated. Obtaining a more accurate understanding of learners’ perceptions, particularly their trust in AI-powered technology, is crucial for preparing for future education because learners’ trust in the technology itself is significantly related to successful technology adoption in various educational contexts. To address this issue, we focused on undergraduate students’ trust in AI-powered chatbots within their courses and investigated the relationship between their trust levels and learning performance. Additionally, we explored the potential association between learners’ trust levels, self-regulated learning, and computational thinking skills. This research employed an exploratory study design with a regular course setting, and there were no experimental treatments involved. In the results, we found that learners’ trust levels were not correlated with their computational thinking, self-regulated learning, or learning performance. Furthermore, these constructs (i.e., self-regulated learning, computational thinking, and learning performance) did not significantly predict learners’ trust in AI. However, there was a notable difference between high and low performers concerning changes in trust over time. Trust levels among low performers exhibited a significant change over the semester, whereas those of high performers remained relatively stable. The study suggests that expectations regarding trusting generative AI technology can be influenced by trusting intention through performance.
Health Gains Arising from Reduced Risk Consumption:South Africa’s PRIME Example
Authors: Koch Steven F.
Published: June 2024

Objectives: Non-communicable diseases (NCDs) account for over 30% of disability-adjusted life years in South Africa. In this research, we offer an estimate of the potential reduction in NCD incidence that would arise from an improvement in diet, combined with a reduction in both tobacco and alcohol consumption.
Methods: We apply the PRIME model, which simulates the effect of risk reduction on NCD incidence. The model inputs baseline data related to the population, risky consumption behaviour and NCD incidence. The model allows for counterfactual scenarios altering the risky consumption behaviour to yield revised NCD incidence.
Results: We find that reducing salt, tobacco and alcohol, along with improved fruit, vegetable and fiber consumption would yield a 10% reduction in NCDs from the 2018 baseline. NCD incidence reductions arise primarily from ischemic heart disease (49%), cerebrovascular diseases (33%) and bronchus and lung disease (11%).
Conclusion: South Africa’s NCD incidence is high because of relatively poor behavioural choices, despite plans and policies aimed at changing this. South Africa should increase their efforts to reach NCD goals. If the government is able to reduce harmful behaviour, with respect to a number of the underlying consumption choices, NCD incidence is expected to fall precipitously.
Targeting TLR4/NF-κB and Nrf2/HO-1 Crosstalk via Trimetazidine alleviates LPS-induced Depressive Like Behaviors in mice
Authors: Mohamed Sarah S. , Rasheed Nora O. Abdel , Ibrahim Weam W. , Shiha Nesma A.
Published: June 2024

Depression is a global psychiatric disorder that imposes a substantial economic burden. Trimetazidine (TMZ); a well-known anti-ischemic drug, could exert neuroprotection in cerebral ischemia.
Aims: This study aimed to investigate the effect of TMZ in lipopolysaccharide (LPS) mouse model of depression with empathises on its ability to regulate toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) as well as nuclear factor erythroid 2 related factor 2 (Nrf2)/ heme oxygenase-1(HO-1) signaling pathways.
Main methods: Male Swiss albino mice were injected with LPS (500 µg/kg, i.p) every other day alone or concurrently with oral doses of either TMZ (20 mg/kg/day) or escitalopram (Esc) (10 mg/kg/day) for 14 days.
Key findings: Administration of TMZ attenuated LPS-induced animals' despair with decreased immobility time in forced swimming test. Additionally, TMZ diminished LPS–induced neuro-inflammation via inhibition of TLR4/NF-κB pathway contrary to Nrf2/HO-1 cascade activation with consequent increase in reduced glutathione (GSH) and HO-1 levels whereas the pro-inflammatory cytokines; tumor necrosis factor –α (TNF-α) and interleukin (IL)-1β were markedly reduced. Besides, TMZ replenished brain serotonin levels owing to serotonin transporter (SERT) inhibition. Thus, TMZ hindered LPS-induced neuro-inflammation, oxidative stress, serotonin deficiency in addition to its anti-apoptotic effect which was reflected by decreased caspase-3 level. The formerly mentioned neuroprotective effects of TMZ were verified by the histological photomicrographs which revealed prominent neuronal survival with minimal records of neuronal damage.
Significance: Consequently, TMZ is proposed as an affluent nominee for depression management via targeting TLR4/NF-κB and Nrf2/HO-1 pathways.
WWP1 targeting PTEN for polyubiquitination to promote bone metastasis of luminal breast cancer
Authors: Jiang Hao , Li Zhenxi , Xu Wei , Xiao Jianru
Published: June 2024

Luminal breast cancer exhibits a high incidence of bone recurrence when metastasizing to distant organs. The mechanisms underlying the organotropism of luminal breast cancer cells remain unclear. In this study, we aimed to determine the role of WWP1 (WW domain-containing E3 ubiquitin protein ligase 1)-PTEN (Phosphatase and tensin homolog deleted on chromosome ten) interaction in bone tropism in luminal breast cancer. We observed that WWP1 was overexpressed in luminal breast cancer tissues and associated with poor prognosis in breast cancer patients. In luminal breast cancer cells, WWP1 was found to mediate PTEN ubiquitination, resulting in the functional loss of PTEN. As a result, we demonstrate that the WWP1 contributes to bone tropism in luminal breast cancer cells via the polyubiquitination of PTEN. Consequently, WWP1-mediated PTEN polyubiquitination contributed to the early metastasis of luminal breast cancer cells to the bone. Thus, our study provides a mechanistic insight into the bone tropism of luminal breast cancer cells and proposes a potential therapeutic strategy for mitigating cancer metastasis to the bone.